SGTCid condition conc unit URH1|YDR400W.score URH1|YDR400W.strain.pval URH1|YDR400W.strain.significant URH1|YDR400W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1501 4491-0275 38.4 µM 4.03460438214656 8.85666684817294e-06 yes 1 2.73471860556199e-05 8 5104718
SGTC_815 1582-0027 36.9 µM 3.94959925291818 1.32629005135716e-05 yes 2 3.91410729346802e-05 26 3128206
SGTC_824 1304-0008 100 µM 3.49120915182411 0.000102277574921498 yes 3 0.000240419838876184 53 768245
SGTC_686 1319-0111 510 µM 3.41719571098847 0.000139251923154954 yes 4 0.000316348891998384 44 4562600
SGTC_2335 9018011 154.17 µM 3.38040476441089 0.000161983598846381 yes 5 0.000361895766992739 44 6458208
SGTC_1748 st037455 53.6035 µM 3.3421497794754 0.000189271850814353 yes 6 0.000415660944365403 57 580690
SGTC_1975 st070967 30.8 µM 3.32732738332214 0.00020095619537774 yes 7 0.000438416469442242 55 261391
SGTC_1701 st028638 40.4 µM 3.3192937360341 0.000207567280484546 yes 8 0.000451227234670363 31 3490878
SGTC_3195 9113082 49.47 µM 3.26698373997672 0.000255834557081683 yes 9 0.000543499617099547 35 17018038
SGTC_415 dibenzyl ketone 100 µM 3.2567023890833 0.000266474910865737 yes 10 0.000563572720398177 33 7593
SGTC_1230 0170-0365 3.77 µM 3.24616745729165 0.000277804361437351 yes 11 0.000584850068803374 111 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2108 5365811 200 µM 3.21281099113322 0.000316704681835317 yes 12 0.000657213795430552 45 780283
SGTC_1467 k284-1082 293 µM 3.17352327213867 0.000369002306516581 yes 13 0.000753004139406408 42 3334705
SGTC_39 0986-0283 58.349 µM 3.04730845534425 0.00059625550421205 yes 14 0.00115450316801061 77 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1179 1021-1431 9.29 µM 3.02208476621194 0.000654937169704241 yes 15 0.0012552011939335 93 2840958
SGTC_3233 9132340 49.47 µM 3.0149582706879 0.000672457063096317 yes 16 0.00128507306988459 60 17682950
SGTC_1214 0358-0031 63.7 µM 2.9484912363382 0.000857963993631278 yes 17 0.00159664596695772 59 4301366
SGTC_2570 licareol 100 µM 2.93493540514439 0.000901152392177276 yes 18 0.00166808565121001 77 443158
SGTC_1470 k295-0292 231 µM 2.85890274753285 0.0011826785899571 no 19 0.00212554545499246 57 5045612
SGTC_3003 9075612 71.4286 µM 2.81808747887681 0.00136506760232245 no 20 0.00241553227890667 71 6501993
SGTC_2462 5162487 171.77 µM 2.80061962071681 0.00145070308950722 no 21 0.00255023000506744 68 2259986
SGTC_549 1661-1316 519 µM 2.7965184207278 0.00147150711772763 no 22 0.00258282330889039 72 2857282
SGTC_3055 9094636 49.47 µM 2.7886264222442 0.00151230840323807 no 23 0.00264660418641384 56 25236176
SGTC_1672 st016598 6.51 µM 2.77195081285808 0.00160193421450903 no 24 0.00278607278248787 142 4665860 YNL267W PIK1
SGTC_827 3253-0474 693 µM 2.76844738430175 0.00162136859823029 no 25 0.00281620396841233 80 5402065
SGTC_2102 5377816 72.7585 µM 2.75734058878434 0.0016844093045546 no 26 0.00291368096147002 84 1379702
SGTC_2792 7535235 81.82 µM 2.75386041747951 0.00170461672431617 no 27 0.00294484405592893 92 1281891
SGTC_3198 9112019 49.47 µM 2.67095069331502 0.00225620168593626 no 28 0.00378183781455573 81 45595555
SGTC_2612 dictamnine 15.46 µM 2.66125014540711 0.00233033508889716 no 29 0.00389255480842088 134 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2982 9019404 25.97 µM 2.6392600843363 0.00250661743299499 no 30 0.00415436050322913 99 22333232
SGTC_3281 9140613 49.47 µM 2.63917585214947 0.0025073152537013 no 31 0.00415539292042117 89 16013766
SGTC_2354 9060492 162 µM 2.60283337224563 0.00282530738312236 no 32 0.00462284387670113 104 6471895
SGTC_1620 st003704 16.5 µM 2.60234222242885 0.00282984347947818 no 33 0.00462947039226763 80 2834414
SGTC_2808 7946468 45.46 µM 2.56552527687507 0.0031891641475329 no 34 0.00515098574813107 121 2970879
SGTC_2288 7946289 167.31 µM 2.5451047081581 0.00340570059451643 no 35 0.00546224872102806 121 1246052
SGTC_1976 st070609 63.5 µM 2.53981606478216 0.00346389287945268 no 36 0.00554553905199301 83 682556
SGTC_3103 9120822 49.47 µM 2.51869646940172 0.00370528457674644 no 37 0.00588950742517822 98 17141819
SGTC_2975 9084847 53.72 µM 2.50468708971229 0.00387362512912135 no 38 0.00612798837732495 141 27211724
SGTC_368 fentichlor 4.58 µM 2.49221981818566 0.00402916440347104 no 39 0.00634737219723071 116 7329 A pesticide.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.48632611511526 0.00410462110066339 no 40 0.00645348140441825 144 442882
SGTC_1213 1315-0166 115 µM 2.48000161006279 0.0041869977073249 no 41 0.00656908947291905 128 768401
SGTC_2896 9052656 71.43 µM 2.46049996926394 0.0044503959485371 no 42 0.00693717919448118 292 6469436
SGTC_143 4032-1194 15.74 µM 2.45911672699601 0.00446962904010698 no 43 0.00696396625104086 200 1806963
SGTC_497 capsazepine 133 µM 2.45458184884676 0.00453320529470758 no 44 0.00705242754178188 97 2733484 A calcium channel blocker.
SGTC_2950 9072895 21.46 µM 2.44119998332308 0.00472554338332516 no 45 0.00731927295035224 173 17332245
SGTC_1968 st069590 43.6 µM 2.44013239020973 0.00474119700952966 no 46 0.00734094011471392 97 6384066
SGTC_2539 epi(13)torulosol 80 µM 2.43540810366877 0.00481102356446331 no 47 0.00743750121839838 134 6708597
SGTC_543 3844-1095 191 µM 2.40693422156521 0.0052516264739071 no 48 0.00804353354726023 175 4230703
SGTC_2355 9061122 103.12 µM 2.391765358845 0.00550070849928823 no 49 0.00838377906360751 97 5302957
SGTC_506 n9-isopropylolomoucine 153 µM 2.3908041141439 0.00551684072984971 no 50 0.00840575986286458 115 6610355
SGTC_391 gliotoxin 8.33 µM 2.38722017950868 0.00557735978968311 no 51 0.00848816032153474 187 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2356 9061756 188.97 µM 2.38629997137835 0.00559299344371866 no 52 0.00850943142861396 91 20104043
SGTC_973 1325-0077 65.9 µM 2.37827485633053 0.0057309923858961 no 53 0.00869692763930153 113 2835149
SGTC_3061 glucosamine 200 µM 2.36221368764881 0.00601628543184947 no 54 0.00908308382058806 96 91431 and experimental redox chemotherapeutic
SGTC_232 clozapine 119 µM 2.35728055316739 0.00610640425311867 no 55 0.0092046662817698 187 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1371 2421-0008 32.7 µM 2.35647687505369 0.0061211986592669 no 56 0.00922460815664185 184 2827552
SGTC_407 eburnamonine 100 µM 2.33779459091531 0.00647417676357254 no 57 0.00969895317603081 127 3195
SGTC_2024 5144227 134 µM 2.33729319593523 0.00648389315543435 no 58 0.00971197204755551 159 3475211
SGTC_2282 7944268 200 µM 2.33608121076719 0.00650743316942035 no 59 0.00974350468521433 186 2970414
SGTC_3314 9135860 59.4275 µM 2.33523889093846 0.00652383778144462 no 60 0.00976547225901987 118 25252478
SGTC_2587 piperic acid 92.2 µM 2.32826615221826 0.00666104600678864 no 61 0.00994898771646614 147 5370536
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.32084376095777 0.006809899381871 no 62 0.0101476388639261 121 756377
SGTC_913 3487-1245 167 µM 2.3172986073069 0.00688202746208825 no 63 0.0102437355625606 173 4016153
SGTC_1948 st076329 66.6 µM 2.30729050694076 0.00708930111197306 no 64 0.0105193151935389 155 24208413
SGTC_970 1315-0089 19.5 µM 2.30513617263882 0.00713463248531328 no 65 0.0105794740916696 135 6811083 YLR033W RSC58
SGTC_685 1278-0033 54.9 µM 2.30133136079786 0.00721531801396391 no 66 0.0106864542081587 163 3590572
SGTC_444 curcumin 90.4 µM 2.29074837518124 0.00744398992212903 no 67 0.0109889855023133 159 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1207 2099-0101 141 µM 2.27859750392584 0.00771439392316724 no 68 0.0113455012313369 157 5837381
SGTC_2794 7785382 27.27 µM 2.2730441019607 0.00784083124615537 no 69 0.0115117612032877 211 2205081
SGTC_2048 5246248 200 µM 2.26824949636085 0.00795145538155163 no 70 0.0116570021022056 99 677046
SGTC_1499 4480-0877 67.3 µM 2.26116038149562 0.00811753451279942 no 71 0.0118746637214124 92 2861909
SGTC_1322 1348-1070 12 µM 2.25021683187656 0.0083798991353961 no 72 0.0122175921653643 101 6758089
SGTC_1141 3253-0389 52.6 µM 2.24141269863776 0.0085963471198668 no 73 0.0124996773569357 106 5402031
SGTC_3085 9117376 49.47 µM 2.20736462798658 0.00948024303434035 no 74 0.0136442977511564 151 16480349
SGTC_3136 9095672 49.47 µM 2.20381497350202 0.0095768156673571 no 75 0.013768679550316 163 17217380
SGTC_2991 9074669 71.4286 µM 2.18865891000657 0.00999889333456311 no 76 0.0143108203090276 229 17333109
SGTC_1411 3909-8223 150 µM 2.17835002490456 0.0102951794734623 no 77 0.0146899937408178 146 X1411
SGTC_2571 chrysanthemic acid 100 µM 2.17476842122504 0.0103998949505717 no 78 0.0148237373192541 145 2743 An insecticide.
SGTC_3081 9117243 49.47 µM 2.17359356868484 0.0104344457899009 no 79 0.0148678359222007 155 45595589
SGTC_1233 0325-0408 14.2 µM 2.16611489445808 0.0106567378405199 no 80 0.0151512041551546 178 12874
SGTC_2100 5377183 190 µM 2.15110967708042 0.0111152122839728 no 81 0.0157337719376414 181 2844202
SGTC_1489 4065-0444 182 µM 2.14930943297019 0.011171353615697 no 82 0.0158049396289953 162 2877968
SGTC_325 2810-4341 181 µM 2.14615069087734 0.0112704562097754 no 83 0.0159304790617883 137 774970
SGTC_529 4076-0302 30.3 µM 2.12989009757309 0.0117927990634845 no 84 0.0165903439352185 183 5816522
SGTC_865 0488-0499 301 µM 2.12349054897538 0.0120040624139347 no 85 0.0168563833165359 163 9634651
SGTC_1954 st077032 68.9 µM 2.12160315333996 0.0120669929557621 no 86 0.0169355386846837 167 698907
SGTC_604 1000-0114 314 µM 2.11198377766961 0.0123921901780776 no 87 0.0173439203705409 194 1572745
SGTC_3193 9111931 49.47 µM 2.10877926147318 0.0125021961986025 no 88 0.0174818197480445 191 17087244
SGTC_551 k048-0028 34.9 µM 2.09206298105875 0.0130898514263701 no 89 0.0182164410600397 202 6836383
SGTC_1456 k015-0012 13 µM 2.08965075732709 0.0131765933908966 no 90 0.0183245917326722 232 2989616
SGTC_1970 st070122 35.8 µM 2.08545224810503 0.0133287538283201 no 91 0.0185141341976408 212 102928
SGTC_3228 9131799 49.47 µM 2.07944521801347 0.0135490956727489 no 92 0.0187882240181503 158 17015818
SGTC_3299 9121982 43.1275 µM 2.07211026674835 0.0138224038063162 no 93 0.0191275795460994 209 17594604 YPL160W CDC60
SGTC_3060 1327-0027 12.5 µM 2.06217153434616 0.0142003089787137 no 94 0.019595703890182 189 16000455 YPR107C YTH1
SGTC_2353 9059630 146.67 µM 2.05962363305344 0.0142986105673059 no 95 0.0197172675648363 155 4779114
SGTC_1147 3809-1045 12.3 µM 2.04890758184858 0.0147184929715242 no 96 0.0202355764093782 223 325925
SGTC_1323 1348-1351 11.2 µM 2.0386311554603 0.0151310692539646 no 97 0.0207434266899949 171 6989654
SGTC_907 3448-6986 75.5 µM 2.02912704293217 0.0155214448474305 no 98 0.0212226760558028 243 590582
SGTC_3062 9077494 49.47 µM 2.02228336050463 0.015807870319007 no 99 0.0215735433151459 220 16459633
SGTC_1815 st051655 58.2 µM 2.01744211455259 0.0160132158560206 no 100 0.0218246980266979 149 5984156
SGTC_2913 7966556 36.57 µM 1.9953342046133 0.0169802478816087 no 101 0.0230032208590517 174 2976516
SGTC_406 estrone 100 µM 1.98878175850977 0.0172762833545535 no 102 0.0233626485380185 188 5870 A steroid.
SGTC_3027 9089541 49.47 µM 1.97858335443175 0.0177458086142168 no 103 0.0239314676438159 230 9943819
SGTC_3201 9113999 49.47 µM 1.96867424639968 0.0182124002653697 no 104 0.0244952552564786 244 16649224
SGTC_844 0330-0132 15.3 µM 1.96344780955005 0.0184626819842611 no 105 0.0247970815845529 221 2828079
SGTC_1347 1493-0251 600 nM 1.92374356877282 0.0204613723255648 no 106 0.0271933669814386 256 3986378
SGTC_958 1222-0007 33 µM 1.92220164787835 0.0205425540304701 no 107 0.0272901947830785 267 7312461
SGTC_2871 9038510 12.99 µM 1.90547447199723 0.0214409088127166 no 108 0.0283592113662241 247 4945164
SGTC_2949 9072542 2.23 µM 1.90400721732539 0.02152127034459 no 109 0.0284546221131557 307 16457352
SGTC_3090 9117696 49.47 µM 1.89812857736368 0.0218458013163918 no 110 0.0288395732353194 215 7923821
SGTC_2829 7992743 58.44 µM 1.89477843186651 0.022032588439064 no 111 0.0290608808796574 296 16462845
SGTC_1369 1866-0067 208 µM 1.88844456990252 0.022389417494202 no 112 0.0294831463425651 303 3531355
SGTC_1458 k015-0034 6.33 µM 1.88742913122088 0.0224470749201326 no 113 0.0295513149936643 231 3598957
SGTC_269 exalamide 29 µM 1.88714667572277 0.0224631352128919 no 114 0.029570300097621 203 3316 A derivative of salicylamide.
SGTC_658 3253-0951 102 µM 1.88408514484564 0.0226378350748533 no 115 0.0297767296370527 350 1184878
SGTC_2809 7964133 12.99 µM 1.88249275940233 0.0227291530905258 no 116 0.0298845710281809 311 1253665
SGTC_1210 3013-0140 750 nM 1.87733449617346 0.0230270966959081 no 117 0.0302361315473645 225 905973
SGTC_705 1124-0212 310 µM 1.87042115132065 0.023431567132635 no 118 0.0307126785112389 275 9554485
SGTC_1413 3910-0535 34.4 µM 1.86957839576166 0.0234812795084891 no 119 0.0307711938496246 248 2876951
SGTC_2650 prasterone 100 µM 1.86764102873529 0.0235958972417629 no 120 0.0309060617596841 146 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1704 st028805 70.8 µM 1.86464793026967 0.0237738986001275 no 121 0.0311153849013301 234 2876101
SGTC_1136 pergolide 1.05886 µM 1.85448484655473 0.0243867494844909 no 122 0.0318349130578156 372 47811 A dopamine receptor agonist.
SGTC_3039 9090270 49.47 µM 1.85066571744031 0.024620452574034 no 123 0.0321088294857137 208 17173750
SGTC_2619 obliquin 87.91 µM 1.83370988820754 0.0256808391712691 no 124 0.0333485350111851 427 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3252 9135871 49.47 µM 1.83073070995054 0.025871044881124 no 125 0.0335703734835454 239 17682838
SGTC_2027 5150920 200 µM 1.82412964855349 0.0262966919307808 no 126 0.0340662370975459 249 786715
SGTC_2787 5284540 71.43 µM 1.82244921224036 0.0264059791723496 no 127 0.0341934266249345 283 736958
SGTC_1301 naphtanilide LB 4.81 µM 1.80721966741205 0.0274138485073046 no 128 0.0353640177896685 266 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2675 theaflavin digallate 100 µM 1.80249922619834 0.0277326781138038 no 129 0.035733448168648 288 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2610 ononetin 44.17 µM 1.80011825641357 0.0278946630870571 no 130 0.0359209837439822 356 259632
SGTC_2649 anisomycin 9.56 µM 1.79880131770596 0.0279845966490667 no 131 0.0360250574153777 214 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_386 1509-0011 3.07 µM 1.79825532412613 0.0280219532227675 no 132 0.0360682779902086 415 3107280
SGTC_742 0kpi-0133 140 µM 1.79585191869783 0.0281868869548094 no 133 0.0362590355084166 292 2728852
SGTC_2724 maprotiline 69.64 µM 1.79080961326639 0.0285355423684476 no 134 0.0366619260353144 251 4011 A tricyclic antidepressant.
SGTC_3247 9135149 49.47 µM 1.78770432595795 0.0287520402659805 no 135 0.036911861719281 238 8934436 YOR116C RPO31
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.78658537899167 0.028830386238675 no 136 0.0370022632800795 368 2724 A muscle relaxant with antifungal properties.
SGTC_1854 st056233 32.9 µM 1.77718346383167 0.0294957213542162 no 137 0.0377690296253266 268 5393174
SGTC_1941 st076221 61.8 µM 1.77416074163928 0.0297123159084703 no 138 0.0380182829308924 376 2828568
SGTC_334 1502-1024 68.5 µM 1.77259415535643 0.0298250885940283 no 139 0.0381479904532277 306 3296216
SGTC_2415 st077333 57.7 µM 1.77200331225566 0.0298677132878446 no 140 0.0381970036997243 376 2766255
SGTC_2768 sulfasalazine 50.2 µM 1.76734349326281 0.030205656442043 no 141 0.0385853600329982 283 5384001 An antioxidant and salicylic acid derivative.
SGTC_659 k018-0002 107 µM 1.76357278969327 0.0304814330012248 no 142 0.0389019661228615 302 6797879 YHR007C ERG11
SGTC_1351 1496-0003 46.5 µM 1.7611944615886 0.0306564462099898 no 143 0.039102747569026 296 3891978
SGTC_370 0180-0345 38.7 µM 1.74719840342499 0.0317033028851522 no 144 0.040301464294495 263 3989527
SGTC_1295 1013-0063 9.78 µM 1.742314723855 0.0320754664709821 no 145 0.0407266942056182 300 6826038
SGTC_155 k072-0202 43.6 µM 1.7413451485537 0.032149781006578 no 146 0.0408115483577164 263 5857737
SGTC_3244 9134489 49.47 µM 1.72608606429496 0.0333381736021672 no 147 0.0421659652698082 316 16584271
SGTC_1208 2323-2347 50.3 µM 1.72269237659536 0.0336073364468341 no 148 0.0424720848309033 284 5412760
SGTC_3259 9138485 49.47 µM 1.7175746691183 0.0340166162586831 no 149 0.0429371119830604 364 17646153
SGTC_3222 9128301 49.47 µM 1.70426507386389 0.0351002495625197 no 150 0.0441657884061276 314 4911358
SGTC_1430 4049-0248 69.1 µM 1.70227664632327 0.0352645482577565 no 151 0.0443517602701065 368 22774488
SGTC_1498 4478-3555 97.6 µM 1.70210439946008 0.0352788102177544 no 152 0.0443678996764416 238 3437919
SGTC_2995 9067767 71.4286 µM 1.69280332087277 0.0360559886897451 no 153 0.0452464551874993 277 11673567
SGTC_1422 4031-0024 15.5 µM 1.68627142799035 0.0366101175901306 no 154 0.0458717658266592 311 782427
SGTC_2012 4023501 200 µM 1.67372020614507 0.0376944445059972 no 155 0.0470928003567722 318 3477460
SGTC_1552 6-methylflavone 10.6 µM 1.66378849115848 0.0385709256675981 no 156 0.0480773523550389 275 689013
SGTC_964 1287-0107 19.4 µM 1.66107320195922 0.038813421655328 no 157 0.0483493728995026 381 51516812 YPR165W RHO1
SGTC_2340 7987427 183.45 µM 1.66039282904792 0.0388743783008249 no 158 0.0484177259008155 329 2239331
SGTC_2815 7968870 71.43 µM 1.65932504748694 0.0389702012243597 no 159 0.0485251553311908 386 2977326 YHR190W ERG9
SGTC_205 1486-1330 71.903 µM 1.65813058862987 0.0390776200071694 no 160 0.0486455555206242 267 4118834
SGTC_869 0564-0080 44.1 µM 1.64711516260674 0.0400796505265749 no 161 0.0497671885561414 386 6843321
SGTC_1102 cgs 12066b 26.1 µM 1.64258034555357 0.0404981862044526 no 162 0.0502348950184195 307 6438352 A 5-HT1B full agonist.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.6425477538887 0.0405012070074343 no 163 0.0502382690546254 371 4174840
SGTC_703 3875-0075 71.8 µM 1.64110736440974 0.0406348942680473 no 164 0.0503875651533685 308 2850814
SGTC_804 1595-0054 20.9 µM 1.63702543152744 0.0410156984039728 no 165 0.0508125779210551 341 761523 Stimulates phospholipase C.
SGTC_69 0096-0274 206.684 µM 1.63579464633608 0.0411310847803171 no 166 0.0509412864363857 422 6741392
SGTC_1310 1188-0297 994 nM 1.63002491823357 0.041675511795942 no 167 0.051548115313448 364 1588352
SGTC_3335 9143315 29.6265 µM 1.62131546665402 0.0425083701709282 no 168 0.0524749998253023 342 4899691
SGTC_196 k015-0023 18.111 µM 1.61725613948931 0.0429011239831035 no 169 0.0529115013378166 379 5211998
SGTC_2929 9013348 24.6 µM 1.61510365846959 0.0431105706196328 no 170 0.0531441244183383 375 2995952
SGTC_290 2043-6722 48.1 µM 1.61030401552364 0.0435805733978175 no 171 0.0536657515253795 354 773758 YLR208W SEC13
SGTC_1054 3429-0080 167 µM 1.60685766364348 0.0439205998563384 no 172 0.0540427976846072 404 1162877
SGTC_2691 st077356 60.2 µM 1.60030355632901 0.0445731482389346 no 173 0.0547656291541334 389 2839272
SGTC_3007 9078383 71.4286 µM 1.58702806292201 0.0459188247090056 no 174 0.0562531444655792 373 6496995
SGTC_916 4466-0038 42 nM 1.5823513614409 0.0464005845380081 no 175 0.056784690831923 506 5722064 YGL116W CDC20
SGTC_299 1273-0059 1.44 µM 1.58028646207994 0.0466145827822362 no 176 0.0570206393769337 352 2848077
SGTC_128 0906-2981 13.371 µM 1.57153437805214 0.0475304221071996 no 177 0.0580292877822615 332 6740226
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.56949058438828 0.0477463523387182 no 178 0.0582668358501715 378 6708760
SGTC_2879 9041815 71.43 µM 1.56935294985887 0.047760921842554 no 179 0.0582828603847814 247 4942971
SGTC_2320 7373003 200 µM 1.55978953321109 0.048782019207998 no 180 0.0594048128639976 380 5415828
SGTC_108 0509-0257 621.132 µM 1.55904030241173 0.0488627468925106 no 181 0.0594934207744796 443 536624
SGTC_542 3381-0244 89.3 µM 1.55485658559084 0.0493154958713059 no 182 0.0599901145045107 450 1112843
SGTC_384 k007-0144 5.16 µM 1.55449801040305 0.0493544551037557 no 183 0.0600328354399251 464 6824886
SGTC_333 3486-0131 40.1 µM 1.55443144060082 0.0493616906235309 no 184 0.0600407692408502 373 6744690
SGTC_809 3998-0021 90 µM 1.55283325753021 0.0495356526473221 no 185 0.0602314875582206 361 715485
SGTC_2916 7875993 68.79 µM 1.55009359557312 0.0498350025020612 no 186 0.0605595265055899 397 1299250
SGTC_676 falcarinol 140 µM 1.54924982097191 0.0499274878341028 no 187 0.0606608385908079 424 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2674 ligustilide 100 µM 1.54492437985474 0.0504037467341478 no 188 0.0611822778067959 352 5319022 A signalling regulator.
SGTC_816 0325-0417 81.3 µM 1.54207785722254 0.0507191373399782 no 189 0.0615273375191326 359 68101
SGTC_1602 st001878 87.6 µM 1.54085689524024 0.0508548989045906 no 190 0.0616758093209374 373 595405 YLR310C CDC25
SGTC_219 mitoxanthrone 164.414 µM 1.53988610718822 0.0509630493998615 no 191 0.0617940589045651 411 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_214 4373-3496 70 µM 1.53628771561997 0.0513655255199809 no 192 0.0622339155060645 564 3779166
SGTC_1813 st051246 8.6015 µM 1.53620602145199 0.0513746921889786 no 193 0.0622439298340156 343 5291959
SGTC_374 0880-0231 82.3 µM 1.53459148959864 0.051556121298874 no 194 0.0624421022153135 403 6833587
SGTC_1889 st059080 5.18 µM 1.5333151325907 0.0516999090961839 no 195 0.0625991139255224 432 176925 Isolated from Daphnopsis sellowiana.
SGTC_1818 st052136 56.3 µM 1.53147448104749 0.0519078285455868 no 196 0.0628260843278215 427 674169
SGTC_2723 salbutamol 83.58 µM 1.52660535622852 0.0524610479817137 no 197 0.0634295871660059 287 9884233 β2-adrenoceptor agonist
SGTC_2322 7413319 38.22 µM 1.51882613300023 0.0533546077237285 no 198 0.0644031330360813 587 1840400
SGTC_2021 4019055 173 µM 1.51405244357688 0.0539088819136268 no 199 0.0650062694473507 601 44827708 YER133W GLC7
SGTC_1060 3448-7350 82 µM 1.5131797524948 0.0540107014369755 no 200 0.0651170029344346 440 570178
SGTC_402 epigallocatechin gallate 10 µM 1.51289138333519 0.0540443797864773 no 201 0.0651536255008788 432 65064 An antioxidant.
SGTC_338 4055-0136 114 µM 1.51175860220283 0.0541768371034542 no 202 0.0652976421858587 420 2900563
SGTC_803 4488-1585 147 µM 1.50758101528553 0.0546675488179679 no 203 0.0658308973265038 370 747204
SGTC_992 3909-8734 162 µM 1.50120441017488 0.0554233318141315 no 204 0.0666513498207012 406 4288319
SGTC_3346 9158254 43.5805 µM 1.49893408655713 0.0556944034599213 no 205 0.0669453662134838 439 17639500
SGTC_2170 morpholine 200 µM 1.49806438651356 0.0557985204871908 no 206 0.0670582614072795 375 121171 Reacts with secondary amines.
SGTC_1657 st012939 43.4 µM 1.4953960059422 0.0561189270617856 no 207 0.0674055611553601 370 24207257
SGTC_763 3453-1109 128 µM 1.49406335824214 0.0562794874527425 no 208 0.0675795299846374 435 1560353
SGTC_2124 5246320 200 µM 1.49304009856895 0.056403017698114 no 209 0.0677133454472993 415 579342
SGTC_729 4092-0585 94.1 µM 1.48937624283195 0.0568470800035246 no 210 0.0681941604560758 398 2169061
SGTC_737 1950-0117 57.9 µM 1.48914296988686 0.0568754458435072 no 211 0.0682248623267923 426 5393513
SGTC_1176 0848-0131 83.3 µM 1.48842633867638 0.0569626574608986 no 212 0.0683192474036857 471 6769040
SGTC_734 2023-0417 80 µM 1.4855368635478 0.0573153655197792 no 213 0.0687008328862652 441 3935732
SGTC_1738 st035555 74 µM 1.48054568005076 0.0579286673168656 no 214 0.0693638397477147 447 5331140
SGTC_590 k048-0076 22.4 µM 1.47872647406767 0.0581534843706159 no 215 0.0696067168545868 425 6832814
SGTC_2325 6158266 200 µM 1.47396359953495 0.0587453266064654 no 216 0.0702456960567005 427 3623240
SGTC_1878 temozolomide 1 mM 1.47222138367843 0.0589629942436759 no 217 0.0704805523791024 393 5394 DNA alkylating agent.
SGTC_995 3931-2021 34.6 µM 1.46966000902429 0.059284153689906 no 218 0.0708269294169185 425 730143
SGTC_1251 0490-5699 265 µM 1.46910695602821 0.0593536782877082 no 219 0.0709018906736324 492 3883818
SGTC_3032 9089427 49.47 µM 1.46877791405237 0.0593950726559851 no 220 0.0709465182004594 410 17173707
SGTC_2712 st079126 47.7 µM 1.46696656256515 0.0596233509144677 no 221 0.0711925758101627 406 3152970
SGTC_1428 4049-0204 61.7 µM 1.46541180581206 0.0598198392782175 no 222 0.0714042991886444 453 X1428
SGTC_1113 artemisinin 1.17947 µM 1.46493834947414 0.0598797747896313 no 223 0.0714688693348187 450 2240 An anti-malaria and mitochondrial poison.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.46033592468848 0.0604648560594052 no 224 0.0720988866767418 309 1241132 A phosphatase inhibitor.
SGTC_33 0986-0033 35.816 µM 1.45618568733642 0.0609962800373198 no 225 0.0726706475161171 398 2848082
SGTC_3191 9110352 49.47 µM 1.456119065836 0.0610048403768243 no 226 0.0726798539166261 397 17122424
SGTC_2311 7694451 200 µM 1.45519922061113 0.0611231292842049 no 227 0.0728070583059636 445 2163142
SGTC_1312 1218-2183 165 µM 1.45318905116443 0.0613822539673664 no 228 0.0730856356288563 452 6744073
SGTC_988 1497-1057 103 µM 1.45277864969841 0.06143526287744 no 229 0.073142610841412 448 3533044
SGTC_2968 9090663 33.37 µM 1.45071896566614 0.0617018392063285 no 230 0.0734290660631685 448 25236811
SGTC_3148 9097893 49.47 µM 1.44590630543819 0.062328241890664 no 231 0.0741017415692918 444 17174100
SGTC_1886 st057356 49.9 µM 1.44580395398515 0.0623416173343341 no 232 0.0741160983944231 423 24207747
SGTC_457 grayanotoxin iii 135 µM 1.44478909548148 0.0624743617514814 no 233 0.0742585674707357 537 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3149 9097855 49.47 µM 1.43991307153199 0.0631152254548048 no 234 0.0749459972020501 442 25236625 YMR079W SEC14
SGTC_649 1123-0311 367 µM 1.43526466219404 0.0637309291035045 no 235 0.0756058467914941 525 693629 YIL048W NEO1
SGTC_1224 0823-0416 294 µM 1.43353767480052 0.0639608635038917 no 236 0.0758521201224586 455 3598164
SGTC_2035 5154463 94.595 µM 1.43324970745892 0.0639992666994232 no 237 0.0758932444480534 485 2769623
SGTC_185 k048-0037 25.491 µM 1.43199128837394 0.0641672993092773 no 238 0.0760731572515332 467 6827589
SGTC_2103 5378138 10 µM 1.43183303460747 0.0641884546731916 no 239 0.0760958053322165 509 244142
SGTC_3063 1327-0034 4 µM 1.43121051879359 0.0642717252007711 no 240 0.0761849448909274 447 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1195 1502-0147 41.1 µM 1.43033049946975 0.0643895837630493 no 241 0.0763110925655927 489 817940
SGTC_859 0439-0102 54.6 µM 1.42842668193813 0.0646451313805253 no 242 0.076584541918414 494 610143
SGTC_1122 capsaicin 818.572 nM 1.42348316248878 0.0653123737365693 no 243 0.0772980698579551 457 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1111 tnp00062 510.699 nM 1.42251782902343 0.065443289147528 no 244 0.0774379897281102 457 676306
SGTC_689 0833-0039 98 µM 1.42098481009184 0.0656516103602246 no 245 0.0776605877133246 470 5374726
SGTC_156 3474-0145 5.642 µM 1.41853872281551 0.0659850721702967 no 246 0.0780167708331501 465 2265471
SGTC_535 2293-4129 48.2 µM 1.417707185055 0.0660987296193161 no 247 0.0781381357501225 559 396118 YIL048W NEO1
SGTC_135 0933-0004 26.348 µM 1.41328552918224 0.0667056459037507 no 248 0.0787858935446661 465 21230617 YGL099W LSG1
SGTC_1946 st076057 65.1 µM 1.41070059005053 0.0670624468060193 no 249 0.0791664584657477 336 953009
SGTC_842 0271-0008 11.1 µM 1.40961388000968 0.0672128860835721 no 250 0.0793268631504641 513 1221709
SGTC_247 mechlorethamine 29.705 µM 1.40915302971579 0.0672767628720685 no 251 0.0793949615602871 400 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_250 brefeldin a 552.239 µM 1.40890161667292 0.0673116301021415 no 252 0.0794321307299957 392 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_458 nppb 133 µM 1.40707095154378 0.0675659373129528 no 253 0.0797031753764057 432 4549 A chloride channel blocker.
SGTC_1004 4084-0029 199 µM 1.40562653936236 0.067767111570117 no 254 0.0799175255231819 531 716894 YLR208W SEC13
SGTC_699 0375-0592 111 µM 1.40546647903602 0.0677894328333565 no 255 0.0799413052108487 478 762578
SGTC_2075 5212009 200 µM 1.40129152641977 0.0683736602140605 no 256 0.0805634570305346 410 780898
SGTC_2524 avocatin b 10.57 µM 1.3996942749398 0.0685981983584801 no 257 0.0808024444691903 436 6710748
SGTC_1793 st048256 72.231 µM 1.39495583856414 0.0692676642510604 no 258 0.0815145785308274 447 672022
SGTC_396 dithiazanine 1.25 µM 1.39072201163709 0.0698700845314457 no 259 0.0821548700729233 441 10578 An antihelmenthic.
SGTC_2138 5575593 77.673 µM 1.38887140686399 0.0701346652676537 no 260 0.0824359283170232 407 762213
SGTC_563 tetrahydrosecaminediol 614 µM 1.37812853639201 0.0716858193356584 no 261 0.0840818032206882 510 334274 A psychoactive constituent of the cannabis plant.
SGTC_1106 tegaserod maleate 11.7 µM 1.37584869841714 0.0720183632100954 no 262 0.0844342404348036 519 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2144 5628481 200 µM 1.37466390013895 0.0721916477577486 no 263 0.0846178339916756 439 2818399
SGTC_1712 st032288 53.4 µM 1.37409178621377 0.0722754375149331 no 264 0.0847065945503671 674 2883011
SGTC_1124 fisetin 1.16336 µM 1.37064194529106 0.0727822693212475 no 265 0.0852433002491716 454 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_251 melphalan 456.522 µM 1.36716885970517 0.0732952604656829 no 266 0.0857861918127156 561 460612 A DNA alkylator.
SGTC_733 4069-0007 56.1 µM 1.3666095807507 0.0733781265424104 no 267 0.0858738562910038 576 5717425 YNL287W SEC21
SGTC_383 2324-0395 7.37 µM 1.36613488564946 0.0734485163802732 no 268 0.0859483152167378 518 3146421
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.36389090679184 0.0737819624624628 no 269 0.0863009515785077 324 6708630 An antioxidant.
SGTC_1842 st055362 61.2 µM 1.35869200283295 0.0745589427249705 no 270 0.0871221036507023 538 676032
SGTC_751 0833-0568 350 µM 1.3567515913594 0.0748505338817401 no 271 0.087430076827016 504 6954252
SGTC_263 alizarin 107.927 µM 1.35644274036461 0.0748970259493161 no 272 0.0874791711044124 584 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_129 0088-0017 176.636 µM 1.35356060818894 0.0753319426167387 no 273 0.0879383007514032 495 182446
SGTC_2337 9009472 200 µM 1.34907356975624 0.0760128691344586 no 274 0.0886566683354786 566 5742383
SGTC_917 harmaline 728.087 nM 1.34640276571261 0.0764203935575687 no 275 0.0890863297416758 528 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2541 muurolladie-3-one 83.07 µM 1.34409976686577 0.0767731292747913 no 276 0.0894580637473889 510 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_605 1315-0399 119 µM 1.34311980090614 0.0769235993587871 no 277 0.0896165924568762 564 24020461
SGTC_316 k060-0003 58.6 µM 1.33541938787918 0.0781137803250947 no 278 0.090869561377555 505 6152314
SGTC_1640 st009078 66.4 µM 1.33375491843333 0.0783728682799723 no 279 0.0911420949539852 453 690618
SGTC_1209 2323-2347 50.3 µM 1.33249130860426 0.0785699939403832 no 280 0.0913493977999624 495 5412760
SGTC_1619 st003326 88.7 µM 1.32734949263087 0.0793760049381025 no 281 0.0921965494953229 490 2849032
SGTC_2145 5634607 200 µM 1.32663755595477 0.0794880968555856 no 282 0.0923143031235638 453 308662
SGTC_2457 5731572 11.68 µM 1.32321356666003 0.0800288658933696 no 283 0.0928821828090918 518 2865357
SGTC_784 4579-0127 173 µM 1.321918970128 0.0802340515537076 no 284 0.0930975673772144 556 1948547
SGTC_55 0767-0285 6.563 µM 1.31974113406298 0.0805801219597809 no 285 0.0934607306907954 575 3116166
SGTC_1261 0712-0010 12.7 µM 1.31774978710517 0.0808975439052513 no 286 0.0937937109964252 571 2840123
SGTC_314 1671-0008 2.74 µM 1.31715149717171 0.0809930958575958 no 287 0.0938939240901031 593 3913060
SGTC_2452 5863136 48.41 µM 1.31609412395117 0.0811621755621005 no 288 0.0940712264824207 519 2184096
SGTC_3338 9144300 39.5675 µM 1.31544115372669 0.0812667219783823 no 289 0.0941808411035726 550 4901274
SGTC_2764 methyldopa 94.69 µM 1.30813206672324 0.082443915141212 no 290 0.095414259359618 561 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_928 2764-0428 58.7 µM 1.30794017485432 0.0824749930730195 no 291 0.0954468007962944 572 662578
SGTC_1893 st059353 36.1 µM 1.30792296731138 0.0824777803590337 no 292 0.0954497192875824 551 3112488
SGTC_339 3091-4833 71.4 µM 1.30523933444174 0.0829133449954264 no 293 0.0959056820893126 527 3240077
SGTC_3216 9129716 49.47 µM 1.30452328942335 0.0830298539727142 no 294 0.0960276120640681 507 8056934
SGTC_2654 protoveratrine a 100 µM 1.29966203303886 0.0838240955185039 no 295 0.0968584142317643 529 5702278 A heart drug and vasodilator.
SGTC_1847 st056231 15 µM 1.2968373519934 0.0842882111601593 no 296 0.0973435779006158 604 5393180
SGTC_59 0330-0160 1.33 µM 1.2929945092376 0.0849227111406877 no 297 0.0980064790759362 702 4293482
SGTC_1790 st045711 43.5 µM 1.29295803959956 0.084928749825208 no 298 0.0980127859977046 548 585119
SGTC_2817 7995342 71.43 µM 1.29045787890185 0.0853434971710809 no 299 0.0984458637172605 474 18879975
SGTC_3142 9086498 49.47 µM 1.28999346772535 0.0854207043505811 no 300 0.0985264630720826 520 25236367
SGTC_701 4424-0219 185 µM 1.28964808916867 0.0854781565710912 no 301 0.0985864354285832 616 2911779
SGTC_2984 9022109 38.96 µM 1.28903424977829 0.0855803374998326 no 302 0.0986930899102558 494 6459207
SGTC_2351 9026858 72.31 µM 1.28474215087929 0.0862973658522437 no 303 0.0994412017584342 511 1409300
SGTC_2483 5729050 27.16 µM 1.28460106422362 0.0863210115094374 no 304 0.0994658633041911 658 2865180
SGTC_1610 st001799 48.1 µM 1.28448980099232 0.0863396622761725 no 305 0.0994853149528389 484 621897
SGTC_193 1273-0060 1.558 µM 1.2797434708547 0.0871380862106439 no 306 0.100317685351853 461 2847393 YHR072W ERG7
SGTC_2999 9069765 71.4286 µM 1.27627086110902 0.0877257295642379 no 307 0.100929893481125 584 2097066
SGTC_342 k048-0088 23.3 µM 1.27412203098088 0.0880908375221059 no 308 0.101310085883203 555 6820570
SGTC_1996 st072960 66.8 µM 1.27363781629669 0.0881732666736836 no 309 0.101395901826943 597 1719405
SGTC_2434 5670830 169.91 µM 1.27059931233465 0.0886918321057917 no 310 0.101935615864562 571 1549830
SGTC_3347 9188721 44.724 µM 1.26626360884698 0.0894357118462991 no 311 0.102709360519183 527 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_298 1391-0729 10 µM 1.26619500067386 0.0894475201835877 no 312 0.102721638467212 526 3237558
SGTC_1504 k297-0033 30 µM 1.26603410437863 0.0894752170263592 no 313 0.102750436251963 459 4388117
SGTC_2905 7799065 20.05 µM 1.26570541935788 0.0895318170050965 no 314 0.102809283687174 533 1296806
SGTC_2444 5485484 36.41 µM 1.26418649922476 0.089793722850459 no 315 0.103081547720751 593 6790631
SGTC_2602 kawain 100 µM 1.26408860719797 0.0898106217867082 no 316 0.103099112657666 629 5369129
SGTC_398 bronopol 33.3 µM 1.2632845696586 0.0899495108944798 no 317 0.103243464770781 571 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_212 3807-4682 38.772 µM 1.26238629287004 0.0901048675547441 no 318 0.103404909535843 731 3125501 YBL034C STU1
SGTC_1938 st074717 56.4 µM 1.26145268276212 0.0902665462727616 no 319 0.10357289878751 511 17250979
SGTC_1035 k081-0041 55.2 µM 1.25759225189921 0.0909373675062083 no 320 0.104269628456954 616 731709
SGTC_1309 pyrazolanthrone 13.4 µM 1.25596697692558 0.0912208927383913 no 321 0.104563971625314 625 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_38 0929-0051 58.268 µM 1.25357180098425 0.091639919288501 no 322 0.104998843072394 625 1379719
SGTC_2823 7987624 58.44 µM 1.25182606121893 0.0919462269343332 no 323 0.105316625802998 611 2239440
SGTC_1663 st014140 55.4 µM 1.24990306358383 0.0922845131366632 no 324 0.105667480087309 665 4207120
SGTC_1472 k841-0093 193 µM 1.24963897079812 0.0923310431518117 no 325 0.105715730200473 623 X1472
SGTC_3278 9139605 49.47 µM 1.24931068286582 0.092388907793084 no 326 0.105775731058559 571 7958859
SGTC_1359 1582-0056 520 nM 1.24748148575663 0.0927118168767175 no 327 0.106110502342586 641 3661189
SGTC_2593 nobiletin 86.24 µM 1.2444161809483 0.0932548067863126 no 328 0.106673215341356 526 72344 An anti-infammatory.
SGTC_1275 0867-0008 21.1 µM 1.24238005639973 0.0936167836387011 no 329 0.107048185208826 585 3422836
SGTC_366 0181-0206 4.31 µM 1.24208648729263 0.0936690590414511 no 330 0.107102326806188 609 274874
SGTC_702 1488-0190 94 µM 1.24044366600428 0.0939619915396934 no 331 0.10740566925849 591 949357
SGTC_788 1182-0090 188 µM 1.23806773951685 0.0943868395680387 no 332 0.107845472296045 722 5715185
SGTC_2146 5545642 200 µM 1.23695695252585 0.0945859486601424 no 333 0.10805153224377 600 825326
SGTC_876 0720-0963 56.8 µM 1.23492284436076 0.0949513658567198 no 334 0.10842961027085 638 765861
SGTC_2243 6634756 200 µM 1.23289936016809 0.0953159053445836 no 335 0.108806657103476 538 885676
SGTC_1649 st011737 51.3 µM 1.23170716475275 0.095531166357694 no 336 0.109029246233419 584 1761035
SGTC_3163 9099914 49.47 µM 1.2306784690765 0.0957171934679098 no 337 0.109221571985216 532 16268368
SGTC_1138 3761-0006 1.03 µM 1.22684979977689 0.0964119036939099 no 338 0.10993952469971 568 12061087
SGTC_512 prima-1 270 µM 1.22501675697419 0.0967458170112214 no 339 0.110284453470567 624 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_492 tmb-8 126 µM 1.22482299765117 0.096781162440764 no 340 0.110320959005845 419 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1789 tunicamycin 25 nM 1.22437133516822 0.0968635911847851 no 341 0.110406088839239 589 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2718 lomofungin 53.02 µM 1.2216141807466 0.0973678919587698 no 342 0.110926781726958 577 5351222 A RNA synthesis inhibitor.
SGTC_3084 9116877 49.47 µM 1.21950712205167 0.0977545826282253 no 343 0.111325887180296 526 27241325
SGTC_2635 hydroquinidine 100 µM 1.21784224845536 0.0980609181299175 no 344 0.111641962965046 606 442912 An experimental heart treatment.
SGTC_3292 9120825 59.784 µM 1.21679942079542 0.0982531555737827 no 345 0.111840270233329 622 24824900
SGTC_289 k017-0060 526 µM 1.21480584691159 0.0986214239264108 no 346 0.112220075153236 579 5512909
SGTC_696 1560-0013 611 µM 1.21320583758078 0.0989177200939822 no 347 0.112525566411843 622 1650269
SGTC_1061 3448-9325 110 µM 1.21217153837636 0.0991096020485857 no 348 0.112723361965506 573 723482
SGTC_934 2950-0684 338 µM 1.21196411734774 0.0991481152992471 no 349 0.112763058263753 642 1121253
SGTC_791 1348-1292 225 µM 1.21022695169362 0.099471096229138 no 350 0.113095909435457 699 5437054
SGTC_3154 9100113 49.47 µM 1.21001642397103 0.0995102905884825 no 351 0.113136295369665 601 25237525
SGTC_3182 9108849 49.47 µM 1.209994056768 0.0995144553977789 no 352 0.113140586717488 635 17133045
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.20617196217321 0.100228007674149 no 353 0.113875596157106 633 688669
SGTC_1115 galangin 695.678 nM 1.20457633107264 0.100527000770007 no 354 0.11418344925351 674 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2847 9005661 71.43 µM 1.20340469328646 0.100746958969383 no 355 0.114409876295365 479 2991449
SGTC_2640 pentamidine 10.38 µM 1.19696612697426 0.101961973698997 no 356 0.115659878870261 677 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_687 k029-0044 34.9 µM 1.19547188125292 0.102245469443532 no 357 0.115951357991587 656 5829338
SGTC_1468 k284-1086 134 µM 1.19197125399394 0.102911869911004 no 358 0.11663625847057 680 15996457
SGTC_2872 9044037 25.97 µM 1.19192043594411 0.102921567122755 no 359 0.116646222142001 562 6465195
SGTC_2875 9039966 71.43 µM 1.19001593300828 0.103285467321903 no 360 0.117020064890057 572 6463691
SGTC_2814 7977482 42.97 µM 1.18765905126676 0.103737097361809 no 361 0.117483881389877 699 6456762
SGTC_80 0159-0065 512.242 µM 1.18709012554884 0.10384633029537 no 362 0.117596036423494 509 1548079
SGTC_1140 3229-1848 2.98 µM 1.18691554949695 0.103879865372288 no 363 0.11763046662305 630 2849525
SGTC_1170 0310-0127 64.8 µM 1.18467440017013 0.104311075369641 no 364 0.118073103966164 653 774975
SGTC_1651 st011928 86.1 µM 1.18320876493871 0.104593772698746 no 365 0.118363210060854 636 720198
SGTC_606 k015-0008 38.6 µM 1.18075493052329 0.10506831936549 no 366 0.118850046479109 695 1970475
SGTC_1555 citronellol 128 µM 1.17902410297412 0.105403979801614 no 367 0.119194289135477 598 8842 A terpine precursor.
SGTC_1591 genipin 88.4 µM 1.17758268742814 0.105684105806566 no 368 0.119481507558639 599 442424 A DNA cross-linking agent.
SGTC_277 nystatin 15.5 µM 1.17743501723154 0.105712834533926 no 369 0.119510960073605 656 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3234 9132280 49.47 µM 1.1767148198156 0.10585302737249 no 370 0.119654675358835 646 17612295
SGTC_757 1066-0008 322 µM 1.17543484551312 0.106102517311744 no 371 0.119910394763406 672 6842497
SGTC_2443 5493264 126.67 µM 1.17515620760427 0.106156885097139 no 372 0.119966113406806 639 5340055
SGTC_2298 7976326 193.81 µM 1.17465643963506 0.10625445015921 no 373 0.120066096686128 567 2235818
SGTC_3117 9124945 49.47 µM 1.17041700931727 0.107084680523293 no 374 0.120916596967414 553 17592065
SGTC_1270 0831-1170 17.3 µM 1.17037934458639 0.107092077518076 no 375 0.120924172090927 709 6764716
SGTC_2888 9058547 12.99 µM 1.16901057614948 0.107361140692213 no 376 0.12119968514447 547 16476514
SGTC_1284 0929-0043 16 µM 1.16867240650289 0.107427690782927 no 377 0.121267821705049 660 1239883
SGTC_2704 st078022 71.1 µM 1.16864656381108 0.107432777717762 no 378 0.121273029761876 652 54697681
SGTC_2054 5233173 129 µM 1.1684678074707 0.107467969280523 no 379 0.121309058689857 697 6889
SGTC_2884 9058502 51.95 µM 1.16779851830763 0.107599805284618 no 380 0.121444022966913 651 6471554
SGTC_1750 st081859 2.357 µM 1.16560853890512 0.108031999966001 no 381 0.121886376935135 812 5291695
SGTC_1831 st055328 12 µM 1.1592280520982 0.109298317911639 no 382 0.123181619921961 673 1103068
SGTC_2373 9071805 200 µM 1.15593780751791 0.10995547552792 no 383 0.123853298340387 661 10149009
SGTC_1961 st076550 68.7 µM 1.15579779432017 0.109983502996188 no 384 0.123881937728245 599 1579337
SGTC_930 2810-3379 265 µM 1.15347811131659 0.11044859712742 no 385 0.124357098379201 741 1015764
SGTC_1098 clofazimine 15.1 µM 1.15115460560196 0.110915869574709 no 386 0.124834318309085 708 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2939 9044578 71.43 µM 1.14961557779739 0.111226156942092 no 387 0.125151119610973 640 2653634
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.14744088690951 0.111665660751136 no 388 0.125599725519183 502 88881 An O-methylated flavonoid and antioxidant.
SGTC_532 1548-0774 215 µM 1.14673536727688 0.111808512435675 no 389 0.12574550433117 697 5932993
SGTC_455 paf C-16 10 µM 1.14649275903261 0.111857665276693 no 390 0.125795660802298 638 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2052 5265182 7.135 µM 1.14561877533689 0.112034863957835 no 391 0.125976462581156 689 1239884
SGTC_24 0417-1663 219 µM 1.14434038527352 0.112294416651344 no 392 0.126241250492392 649 4329390
SGTC_644 1498-1197 63.3 µM 1.14146580669613 0.112879613677793 no 393 0.126838066690148 707 6741615
SGTC_775 4577-0580 57.3 µM 1.14140365469664 0.112892290371251 no 394 0.126850992264207 685 2006902
SGTC_1991 st073000 8.92 µM 1.13607278285232 0.113983374048637 no 395 0.127963052374671 731 4301969 YIL048W NEO1
SGTC_2970 9090938 41.86 µM 1.13543402984927 0.114114611653958 no 396 0.128096754103496 755 17217104
SGTC_1861 st057647 17.4 µM 1.13529063386979 0.114144088447714 no 397 0.128126782621954 691 688668
SGTC_3186 9110464 49.47 µM 1.13141100772141 0.1149436520639 no 398 0.128941070268874 671 17018021
SGTC_558 k064-0027 21.3 µM 1.12998693201326 0.115238141184717 no 399 0.129240865496343 689 5088526
SGTC_1611 st001856 99.4 µM 1.12844591259173 0.115557417251867 no 400 0.129565823536978 656 647478
SGTC_42 0133-0086 60.653 µM 1.12737379282205 0.115779914755273 no 401 0.12979223731982 607 162923 Model of phenazepam hydroxylation.
SGTC_1244 0416-0015 52.5 µM 1.12431797675411 0.116415758583626 no 402 0.130439077375004 666 96201
SGTC_1026 k007-1105 30.6 µM 1.12359358240695 0.116566850622893 no 403 0.130592739945509 749 7066794
SGTC_3044 9093193 49.47 µM 1.1196300128357 0.117396022577252 no 404 0.131435730226204 693 25236277
SGTC_1393 3470-5649 58.2 µM 1.11827025453957 0.11768144160877 no 405 0.13172579348265 578 4108395
SGTC_1011 4112-3381 17.4 µM 1.11749072472698 0.117845289542274 no 406 0.131892281612073 696 2877139
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.11599906023211 0.118159269570003 no 407 0.13221126843623 501 4000243
SGTC_882 0843-0131 351 µM 1.11508016695461 0.118352981363471 no 408 0.13240803481832 748 5425421
SGTC_1081 sertraline 6 µM 1.11477413170777 0.118417546429697 no 409 0.132473612175714 718 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2767 sibutramine 71.45 µM 1.11211208404058 0.118980215979769 no 410 0.13304498085007 719 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_83 0170-0301 39.027 µM 1.110947532796 0.119226956574962 no 411 0.133295466921676 608 3089716
SGTC_1760 st045453 10.4495 µM 1.11003928765615 0.119419642546471 no 412 0.133491048581145 731 3323419 YIL048W NEO1
SGTC_1794 st048918 76.9 µM 1.10937788126505 0.119560099392194 no 413 0.133633600084762 615 672303
SGTC_2046 4110841 106 µM 1.10873406483576 0.119696932704607 no 414 0.133772460959796 700 44119630 YMR134W ERG29
SGTC_3164 9100705 49.47 µM 1.10777082353344 0.119901861040639 no 415 0.133980401815055 648 17174235
SGTC_595 3909-8003 73.7 µM 1.10767303779572 0.119922678650131 no 416 0.134001523838564 693 699517
SGTC_646 4092-0839 27.3 µM 1.10591534840561 0.12029730779201 no 417 0.134381580435823 704 877796
SGTC_2174 5790901 200 µM 1.10520782124998 0.120448340694423 no 418 0.134534774310473 676 786020
SGTC_1686 st019653 115.5 µM 1.1037988136678 0.120749513405322 no 419 0.134840209798854 705 97252
SGTC_3151 9099821 49.47 µM 1.10327601609609 0.120861395114916 no 420 0.134953659365702 673 17174189
SGTC_320 4092-0846 5.34 µM 1.10274072184686 0.120976026757297 no 421 0.135069888592307 709 1359356
SGTC_1123 mangostin 811.285 nM 1.10073663025379 0.121405876163567 no 422 0.135505649455389 675 5281650 An antioxidant.
SGTC_935 2996-0153 430 µM 1.09412741925345 0.122831064645767 no 423 0.136949549181707 719 23738523
SGTC_1955 wogonin 32.4 µM 1.09132386861878 0.123439143203749 no 424 0.137565199317324 691 5281703 A flavanone.
SGTC_3315 9136395 68.55 µM 1.08942976338803 0.123851158524294 no 425 0.13798220611659 783 16876844
SGTC_2492 derrusnin 100 µM 1.08924859280174 0.123890618045347 no 426 0.138022137820703 649 1715307 Part of coumarin class of compounds.
SGTC_3208 9114115 49.47 µM 1.08851994883626 0.1240494078421 no 427 0.138182817404376 626 650895
SGTC_2546 rhodinyl acetate 100 µM 1.08075284081794 0.125750908257915 no 428 0.139903535588322 758 6708682
SGTC_2915 7971052 15.16 µM 1.08038202034398 0.125832547202631 no 429 0.139986049468976 557 5741558
SGTC_1908 st060353 56.5 µM 1.07846725433209 0.126254685715529 no 430 0.140412643760803 784 4227716
SGTC_1636 st007707 68.9 µM 1.07838917788064 0.126271919743267 no 431 0.140430057269234 764 403051
SGTC_780 0109-0199 192 µM 1.07831881445719 0.12628745265781 no 432 0.140445751785535 776 610414
SGTC_670 4204-0025 119 µM 1.07627772167371 0.126738609000018 no 433 0.140901534565855 763 719039
SGTC_1745 st081495 74 µM 1.07203467125219 0.127680067053687 no 434 0.14185222980115 794 13842402 YBL026W LSM2
SGTC_912 3474-0017 2.18 µM 1.06994830298052 0.128144773910096 no 435 0.142321289605595 750 3360550
SGTC_3237 9133362 49.47 µM 1.06153396083476 0.130030856702788 no 436 0.144223653819029 730 43845137
SGTC_3068 9116768 49.47 µM 1.06001053782651 0.130374377281372 no 437 0.144569902641774 681 41904888
SGTC_2219 9098279 200 µM 1.05893481954465 0.130617321582654 no 438 0.144814732663494 737 902349
SGTC_2742 clothiapine 36.27 µM 1.05606924374145 0.131266020958958 no 439 0.145468290362336 698 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2081 5214970 32.255 µM 1.05494911864758 0.131520194903841 no 440 0.145724298006993 743 2063512
SGTC_1143 3454-2408 5.08 µM 1.0531839867906 0.131921420108713 no 441 0.146128338056509 714 X1143
SGTC_2368 9071271 200 µM 1.05227663677562 0.132127994493028 no 442 0.146336323729102 716 27209959
SGTC_990 3985-0011 41.3 µM 1.04893732618364 0.132890168297664 no 443 0.147103482402495 683 5399565 YGL099W LSG1
SGTC_941 3237-0776 460 µM 1.04818189975897 0.133063008021529 no 444 0.147277404107878 727 760008
SGTC_761 k216-0224 480 µM 1.04660660736247 0.133423928669345 no 445 0.147640526627971 817 1340404
SGTC_1387 3342-1166 1.8 µM 1.0456615543655 0.133640775886116 no 446 0.147858659464722 685 3418228
SGTC_1717 st033143 58.0435 µM 1.04552761960901 0.133671527491131 no 447 0.147889591124144 783 674616
SGTC_624 k048-0052 28 µM 1.0453649144829 0.133708891357328 no 448 0.147927173004865 723 6835531
SGTC_3001 9076041 71.4286 µM 1.04213965949989 0.134451026146578 no 449 0.148673466820839 734 16004211
SGTC_488 nitrendipine 139 µM 1.04172634851795 0.134546333495404 no 450 0.148769284725858 803 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1729 st035615 45.989 µM 1.04061143302124 0.134803658411331 no 451 0.149027961429864 736 17385451
SGTC_2391 6285546 200 µM 1.03978385400297 0.13499488365347 no 452 0.149220166042118 781 846083
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.0358771007475 0.135900112505732 no 453 0.150129740993976 715 15053
SGTC_537 1334-0398 209 µM 1.03375179411051 0.136394306304668 no 454 0.150626106409604 796 5846986
SGTC_2142 5622915 118.518 µM 1.03127368578365 0.136972087163843 no 455 0.151206247295813 735 5322196
SGTC_2117 5521686 200 µM 1.03021008399983 0.137220582418852 no 456 0.151455698516955 757 803312
SGTC_843 0310-0051 143 µM 1.03004836709956 0.13725839219834 no 457 0.151493650647136 772 2065037
SGTC_2273 7815444 169.05 µM 1.03003816930776 0.137260776703758 no 458 0.151496044102561 752 2824616
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.02625257418281 0.138147901092269 no 459 0.152386272836518 741 4330530
SGTC_3069 9117009 49.47 µM 1.02609381982486 0.138185189144807 no 460 0.152423681556836 641 41904981
SGTC_1658 st012944 20 µM 1.02559303753718 0.138302857310803 no 461 0.152541725333975 754 24207260
SGTC_1211 1056-0033 32.3 µM 1.02514623059009 0.13840790060105 no 462 0.152647097301672 806 6741922
SGTC_1621 st003705 32.4 µM 1.02219650590582 0.139102738398472 no 463 0.153343952100981 824 24207032
SGTC_1242 0402-0103 60.1 µM 1.0209893191889 0.139387787082406 no 464 0.15362974954841 729 432868
SGTC_1212 0520-0165 585 µM 1.02046886625732 0.139510802277668 no 465 0.153753073788054 753 5403258
SGTC_3030 9087619 49.47 µM 1.02038826015401 0.139529861083484 no 466 0.153772179715237 767 25236973
SGTC_1859 st055998 20 µM 1.01984022801606 0.139659486779375 no 467 0.153902120502347 810 676301
SGTC_2910 7948405 25.97 µM 1.01776666860957 0.140150685342743 no 468 0.154394427829453 736 2971328
SGTC_850 0388-0143 75.9 µM 1.01693135946575 0.140348890152641 no 469 0.154593041949715 740 67273
SGTC_1286 0929-0070 131 µM 1.01566027310737 0.140650862617016 no 470 0.154895596045346 822 1420408
SGTC_836 0330-0104 1.35 µM 1.01556493635424 0.140673529569114 no 471 0.154918304615176 780 46494820
SGTC_32 0928-0142 34.1 µM 1.01325883772058 0.141222575283136 no 472 0.155468271577258 782 2244242
SGTC_1928 4'-methoxychalcone 40.3 µM 1.0071871938154 0.14267507851098 no 473 0.156922412973183 830 641818
SGTC_107 0358-0022 2.6945 µM 1.00615409966766 0.142923224840189 no 474 0.157170724018917 658 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1688 st021091 57.6 µM 1.00584212519171 0.142998217541516 no 475 0.157245759924671 815 3656366
SGTC_255 tunicamycin 200.472 nM 1.00515576712401 0.143163298482984 no 476 0.157410925235766 800 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2749 bexarotene 57.39 µM 1.00225528403285 0.143862335718338 no 477 0.158110156588093 760 82146 An retinoic acid receptor inhibitor.
SGTC_1130 3454-2858 15.9 µM 0.998788298028702 0.144700920617147 no 478 0.15894862796864 768 715628 YIL048W NEO1
SGTC_953 1188-0045 9.7 µM 0.995475015111556 0.145505399047557 no 479 0.159752645029253 813 6144426
SGTC_1112 tnp00069 1.16933 µM 0.993911560217524 0.145886054764344 no 480 0.160132962907442 853 145826
SGTC_2131 toluylene red 5.2905 µM 0.993651147259331 0.145949522691033 no 481 0.160196367065828 788 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1280 0880-0253 10.1 µM 0.992145592814915 0.146316820559364 no 482 0.16056325424599 817 6836607
SGTC_752 1896-0090 130 µM 0.988474040065699 0.147215139900081 no 483 0.161460271084304 829 772567
SGTC_539 4859-0462 2.54 µM 0.988366404285911 0.147241530823234 no 484 0.161486617370332 831 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3205 9113483 49.47 µM 0.986829700557763 0.147618656844249 no 485 0.161863065953615 819 17018033
SGTC_1606 st000094 49.2 µM 0.986454908805863 0.147710733411031 no 486 0.161954965904176 869 1242210
SGTC_2923 7992654 58.14 µM 0.984173174116763 0.148272125908158 no 487 0.162515186620034 792 2985126
SGTC_1055 3448-0672 86 µM 0.984009467430664 0.148312458712002 no 488 0.162555428970292 788 748378
SGTC_927 2425-1185 123 µM 0.981742936186492 0.148871623562125 no 489 0.163113253528416 802 730375
SGTC_491 tetrandrine 80.3 µM 0.979404498073519 0.149450002818223 no 490 0.163690077741315 797 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1834 st055981 52.8 µM 0.978813274414436 0.149596470766948 no 491 0.16383612477936 841 471719 YDL150W RPC53
SGTC_2413 inermin 26.06 µM 0.977255981367625 0.149982728104634 no 492 0.164221219742862 846 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_749 1000-0129 128 µM 0.973786384693542 0.150845685861278 no 493 0.165081307379567 877 708470
SGTC_1206 3978-0017 132 µM 0.970476550155738 0.151671982203771 no 494 0.165904504038001 778 3873677
SGTC_2393 9031399 185.94 µM 0.970005945413146 0.151789711944596 no 495 0.166021764306441 836 1526623 YDL150W RPC53
SGTC_2625 euphol 100 µM 0.968322981097066 0.152211230706564 no 496 0.166441545485224 854 6708538 A triterpene alcohol.
SGTC_1756 st041558 35.5 µM 0.967690226449907 0.15236991260053 no 497 0.166599550349175 922 3955792
SGTC_1891 st059073 26.2 µM 0.965848459018423 0.152832414846527 no 498 0.16706000801781 917 688754
SGTC_493 zm226600 134 µM 0.965056473701302 0.153031583116989 no 499 0.167258263216936 838 5240098 A potassium channel opener. YCR052W RSC6
SGTC_151 3013-0144 2.285 µM 0.964476413894286 0.153177565520952 no 500 0.167403563938132 838 906558 YHR107C CDC12
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.963033502730258 0.153541100058502 no 501 0.167765355280836 889 6708739 YPR165W RHO1
SGTC_1435 4092-0789 56.7 µM 0.961988137629461 0.153804831408657 no 502 0.168027781351316 844 2248285
SGTC_1465 k213-0056 144 µM 0.961395645919914 0.153954442037829 no 503 0.168176636354467 812 24048857 YMR208W ERG12
SGTC_99 0109-0120 622.8 µM 0.961239178165132 0.1539939679235 no 504 0.168215960779675 809 759414
SGTC_877 0771-0151 33.1 µM 0.956492857350736 0.155196144132798 no 505 0.169411645637114 864 6166523
SGTC_1980 st071811 45.7 µM 0.95451638827909 0.155698578092103 no 506 0.16991115889752 844 4974850
SGTC_159 3970-0959 50 µM 0.953801889408332 0.155880473006974 no 507 0.170091966419447 1016 6615653
SGTC_1998 st075797 76.8 µM 0.95241454652577 0.156234058401478 no 508 0.170443392511 932 24208315
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.949832957454458 0.156893420888488 no 509 0.171098568347279 921 1273210
SGTC_1133 3473-0247 50 µM 0.948469658077973 0.157242358218541 no 510 0.171445206139884 809 711311
SGTC_2880 9042983 58.44 µM 0.947146243833707 0.157581574629444 no 511 0.171782131603049 840 6464714
SGTC_3129 9127257 49.47 µM 0.94667804071609 0.15770169911364 no 512 0.171901431728065 721 837894
SGTC_1345 1488-0192 31.4 µM 0.946628848239142 0.157714323667533 no 513 0.171913969248699 889 658348
SGTC_616 4092-0450 108 µM 0.944400580843711 0.158286873094982 no 514 0.172482492389233 884 787165
SGTC_3270 9137563 49.47 µM 0.944299751607818 0.158312813204281 no 515 0.172508246421319 819 17015724
SGTC_182 3448-4371 550.524 µM 0.943791888702076 0.158443512347766 no 516 0.172638003198192 914 3491403
SGTC_2112 5488546 200 µM 0.943373288928976 0.158551292710645 no 517 0.172745000400023 851 600757
SGTC_602 3130-1533 38.1 µM 0.943214462126343 0.158592199747512 no 518 0.172785608766481 908 720941
SGTC_1200 1643-0193 18.4 µM 0.94062976040798 0.159258881794812 no 519 0.173447312679393 918 5403974
SGTC_1129 3453-1384 223 µM 0.9393238794461 0.159596409591702 no 520 0.173782240954954 896 1084452
SGTC_2960 9079389 5.97 µM 0.938722750382941 0.159751939164814 no 521 0.173936554838181 878 16457355
SGTC_477 mead ethanolamide 10 µM 0.937516473561258 0.160064337117548 no 522 0.174246476990484 743 16061185
SGTC_3272 9137413 49.47 µM 0.936863818530439 0.16023352617325 no 523 0.174414306306325 839 17614870
SGTC_3177 9107506 49.47 µM 0.93548392524891 0.160591623340152 no 524 0.174769481844403 844 8897194
SGTC_1799 st045822 46.1415 µM 0.933898711984106 0.161003647950108 no 525 0.175178071658059 864 3674992
SGTC_518 1021-0119 62.6 µM 0.933481309207321 0.161112252870109 no 526 0.17528575819758 810 1097762
SGTC_2283 7944793 200 µM 0.932951170882242 0.161250259589826 no 527 0.175422590095939 870 2970533
SGTC_352 k048-0007 5.11 µM 0.93203312020847 0.161489430811142 no 528 0.175659704620579 921 6811911
SGTC_822 1487-0950 154 µM 0.931226507942257 0.1616997608129 no 529 0.175868204298732 883 1958375
SGTC_2522 biochanin a 4.94 µM 0.931119334738074 0.161727720434988 no 530 0.175895919089084 858 5280373 A possible chelator.
SGTC_725 1497-0963 19 µM 0.928349905627417 0.162451308807957 no 531 0.176613047322797 913 3549977
SGTC_486 niguldipine 82 µM 0.928296204720663 0.162465360415456 no 532 0.176626971121407 842 1236 A calcium channel blocker.
SGTC_598 3937-0236 20.2 µM 0.928144423687034 0.162505080362812 no 533 0.176666329304301 942 1379313
SGTC_1963 st076565 50.3 µM 0.927380131257295 0.162705185918938 no 534 0.176864601441836 861 4914280
SGTC_2341 7987486 176.74 µM 0.926457382921004 0.162946991565146 no 535 0.177104167407482 912 1258686
SGTC_1215 3852-0577 11.2 µM 0.926254334347124 0.163000231667894 no 536 0.177156910831887 952 2884876
SGTC_738 1315-0003 72.4 µM 0.924821661663934 0.163376205196163 no 537 0.177529340477711 900 6251474
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.924785475432634 0.163385708767293 no 538 0.17753875364366 913 23847180
SGTC_996 3970-0799 1.8 µM 0.92457775140974 0.163440270166684 no 539 0.177592795226841 1072 6615648 YGL040C HEM2
SGTC_2014 4013930 200 µM 0.923827465373543 0.163637441046971 no 540 0.177788076461411 942 64556
SGTC_2750 bromebric acid 70.15 µM 0.923104934949248 0.16382746381903 no 541 0.177976261566699 929 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_230 MPP+ 141.667 µM 0.922542426786784 0.163975500448091 no 542 0.178122855343283 837 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_961 1252-1571 372 µM 0.921857014624563 0.164155999288873 no 543 0.178301581655803 899 6813498
SGTC_52 0329-0193 875 nM 0.920299772854327 0.16456656758536 no 544 0.178708063875108 853 3739292
SGTC_1897 st060201 15 µM 0.920198329331102 0.164593336335662 no 545 0.178734563604754 827 611878
SGTC_1318 1280-3875 124 µM 0.919837954333234 0.164688454313321 no 546 0.178828723083336 891 373245
SGTC_1509 1326-1131 80 µM 0.917996289537794 0.165175102311491 no 547 0.179310404207975 875 768313
SGTC_2852 9023854 51.95 µM 0.917812544680952 0.165223706713986 no 548 0.179358506765891 881 19798528
SGTC_607 4491-0986 66.8 µM 0.916512772741397 0.165567788190265 no 549 0.179699005661211 923 698981 YDR232W HEM1
SGTC_1481 3346-2004 36 µM 0.915878606002718 0.165735835759624 no 550 0.179865284496213 922 2770522
SGTC_2756 carbadox 75.1 µM 0.915351825727909 0.165875510853695 no 551 0.180003480000306 857 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2327 6189656 200 µM 0.913892228238471 0.166262918540226 no 552 0.180386738889103 897 5349088
SGTC_2965 9082772 38.63 µM 0.912797159428094 0.166553956061032 no 553 0.180674616283166 927 16459634
SGTC_3246 9135460 32.98 µM 0.91255120879804 0.166619367798593 no 554 0.180739312660498 830 41446951
SGTC_1997 st073024 93.8 µM 0.910751394482311 0.16709854146066 no 555 0.181213188893952 906 686268
SGTC_2116 5511452 16.8835 µM 0.910332739543794 0.167210129332376 no 556 0.181323528736682 905 870744
SGTC_2505 galangin 7.89 µM 0.910022301037085 0.167292904312569 no 557 0.181405374434661 827 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1910 st062352 60.4 µM 0.909979941054454 0.16730420117889 no 558 0.18141654424415 913 2245730
SGTC_1469 k284-2957 126 µM 0.908364505665977 0.167735384037023 no 559 0.181842836079737 901 23884841
SGTC_1377 2944-0135 198 µM 0.907820291876433 0.167880803496383 no 560 0.18198658781161 926 1894137
SGTC_2242 6630449 61.2675 µM 0.907778951006801 0.167891853513026 no 561 0.181997510727751 798 691249 YDR170C SEC7
SGTC_2856 9022925 19.48 µM 0.907635210369787 0.167930277646139 no 562 0.182035492483715 888 4944862
SGTC_2545 solidagenone 89.61 µM 0.907634643701014 0.167930429136816 no 563 0.182035642229014 686 6708572 An anti ulcer agent
SGTC_1553 gossypol 38.6 µM 0.906574727066278 0.168213936430476 no 564 0.182315865740746 820 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1254 0550-0035 264 µM 0.906413683648259 0.168257039375136 no 565 0.18235846639453 947 15121435
SGTC_1030 k029-0042 36.7 µM 0.906188181952788 0.168317406385378 no 566 0.182418128582574 923 6080581
SGTC_468 gf-109203x 121 µM 0.905676824816789 0.168454348762898 no 567 0.18255346624474 793 2396 A protein kinase C inhibitor.
SGTC_1390 3413-2614 145 µM 0.905582383808831 0.168479648073078 no 568 0.18257846820824 929 3421432
SGTC_428 3448-4153 16.5 µM 0.905081662918467 0.1686138243984 no 569 0.182711062929761 816 3834874
SGTC_459 nigericin 15.3 µM 0.90399193769347 0.168906071375137 no 570 0.182999838237121 962 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_104 0074-0074 590.992 µM 0.900755405277711 0.169775975071048 no 571 0.183859191475446 772 3943124
SGTC_1173 0443-0020 122 µM 0.900555839075383 0.169829707643646 no 572 0.183912261762942 895 5331295
SGTC_3050 9093513 49.47 µM 0.900308742892448 0.169896252621881 no 573 0.183977984831037 931 25236664
SGTC_2198 6589944 200 µM 0.896079018955807 0.171037942708424 no 574 0.185105280923292 833 5290268
SGTC_3188 9110789 49.47 µM 0.895045085692828 0.171317767412141 no 575 0.185381493637798 906 849217
SGTC_1291 0993-0025 5.79 µM 0.894896711693169 0.171357947495457 no 576 0.185421152368686 940 4353356
SGTC_1023 4482-3888 16 µM 0.892479102641257 0.172013491206985 no 577 0.186068094413825 914 3303168
SGTC_3189 9110682 49.47 µM 0.891857478613148 0.172182305284473 no 578 0.186234664271606 902 17122418
SGTC_2981 9013952 38.96 µM 0.891532220053988 0.172270677681792 no 579 0.186321857096692 856 2996344
SGTC_2720 fluspirilene 36.88 µM 0.891271465053389 0.172341545428594 no 580 0.186391776564173 845 3396 An atypical antipsychotic.
SGTC_1344 1488-0097 29.1 µM 0.890054574627351 0.172672516632408 no 581 0.186718291338854 901 747966
SGTC_2279 7948423 32.93 µM 0.889983468293523 0.172691868734281 no 582 0.186737381459426 911 1247112
SGTC_841 0251-0215 91.2 µM 0.889510527571914 0.172820618143398 no 583 0.186864383945422 960 3888614
SGTC_650 1328-0195 38 µM 0.885160142143286 0.174007798818114 no 584 0.188035132982185 940 2780821
SGTC_3327 9140648 26.9345 µM 0.884225569743511 0.174263510124316 no 585 0.188287228948177 932 8029710
SGTC_2765 myclobutanil 7.74 µM 0.882855141029809 0.174638909010023 no 586 0.188657271709244 913 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2807 7945238 51.95 µM 0.882645597532369 0.174696354080308 no 587 0.188713892072875 922 17148797
SGTC_697 0508-1955 564 µM 0.8816586319721 0.174967085958599 no 588 0.188980719051041 971 6243113
SGTC_2487 5918373 44.05 µM 0.879043261831361 0.175685787739018 no 589 0.189688909759404 998 2876279
SGTC_377 3970-0964 33.1 µM 0.877694275504316 0.176057218317967 no 590 0.190054825951238 1008 16481235
SGTC_1148 3909-7663 27.7 µM 0.877547004952235 0.176097797944822 no 591 0.190094799735988 966 4084526
SGTC_1568 digitonin 820 nM 0.872630611959701 0.177455881233624 no 592 0.191432224770959 982 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_111 0083-0039 52.457 µM 0.869939130619557 0.178202157420721 no 593 0.192166834763301 856 759313
SGTC_1405 3909-7894 12 µM 0.869833741043514 0.1782314193345 no 594 0.192195634723157 959 7104060
SGTC_424 splitomicin 100 mM 0.86855147415704 0.178587689332646 no 595 0.192546253087574 870 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2496 diffractaic acid 79.83 µM 0.866490259254752 0.179161324455945 no 596 0.193110682901251 966 94870 An apoptosis inducer which activates caspases.
SGTC_2525 harmine 47.85 µM 0.866304401545033 0.179213105471297 no 597 0.193161626579724 912 5280953 A monoamine oxidase inhibitor
SGTC_2371 9071574 200 µM 0.864405266743656 0.179742754609075 no 598 0.193682650330861 938 45596039
SGTC_2350 9023895 38.85 µM 0.863387363648142 0.18002704168715 no 599 0.193962262360996 936 2997209
SGTC_2004 4023728 41.89 µM 0.861631651521199 0.180518052232053 no 600 0.194445123894533 976 360084 YDR527W RBA50
SGTC_974 1326-0144 138 µM 0.861224679507573 0.180631987710811 no 601 0.194557155009323 968 5411856
SGTC_867 0518-0118 155 µM 0.858875590627862 0.181290517330493 no 602 0.195204578814161 1003 6848158
SGTC_2568 diosmetin 100 µM 0.857753810172604 0.181605520314627 no 603 0.195514209974825 973 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1637 st007924 17.4 µM 0.854227898795669 0.182597846773377 no 604 0.196489363953467 916 683336
SGTC_216 k038-0035 28.382 µM 0.853054139270306 0.182928937476187 no 605 0.196814640945444 928 4444231 YPR107C YTH1
SGTC_620 0109-0052 432 µM 0.853025565368207 0.182937002188504 no 606 0.196822563524246 992 493037
SGTC_806 3966-4455 5.86 µM 0.852949793457309 0.182958389164541 no 607 0.196843573453161 871 714982
SGTC_894 0960-0238 55.9 µM 0.852098677440333 0.183198727820252 no 608 0.197079662988944 987 6741907 YDL195W SEC31
SGTC_672 1441-0018 53.7 µM 0.851548583097638 0.183354168505882 no 609 0.197232343795495 924 251141
SGTC_1145 3546-0597 10.2 µM 0.851413240415362 0.183392425018516 no 610 0.19726991964503 971 875334
SGTC_2549 cedrol 20.94 µM 0.851144570801093 0.18346838300683 no 611 0.197344524531206 948 6708665 A sedative which affects the nervous system.
SGTC_1634 st006576 41 µM 0.850904628589649 0.183536235789224 no 612 0.197411166739848 966 3915356
SGTC_470 aa-861 153 µM 0.850792351073645 0.183567991896313 no 613 0.197442355679023 963 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1969 st069479 40.1 µM 0.848088803151184 0.184333685847661 no 614 0.198194258410931 936 3895485
SGTC_1671 st016596 74.5 µM 0.847708635003208 0.184441515525614 no 615 0.198300128100665 1019 2829167
SGTC_715 0868-0130 184 µM 0.846968806589186 0.184651470541456 no 616 0.198506254236823 976 2876258
SGTC_1531 st059297 52.4 µM 0.842174436558468 0.18601565819232 no 617 0.199845160286193 989 7566702
SGTC_2669 eugenol 100 µM 0.84093626817956 0.186368978657734 no 618 0.200191819496815 962 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1086 cerivastatin 2.18 µM 0.837536142409241 0.187341366085897 no 619 0.201145635058715 977 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_234 nsc-17383 10.7 µM 0.837133386097038 0.187456756047911 no 620 0.201258797962361 1044 408974
SGTC_2493 resveratrol 26.09 µM 0.835757822872585 0.187851186969819 no 621 0.201645579241276 932 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1635 st007035 42.4 µM 0.835741236425717 0.187855946115782 no 622 0.201650245738526 1045 3716403
SGTC_2584 androsterone 48.74 µM 0.832601076471821 0.188758292607838 no 623 0.202534875846935 1116 2754130 A steroid.
SGTC_724 3910-0327 137 µM 0.832220618448009 0.188867800976498 no 624 0.20264221391928 1013 2885483
SGTC_1168 k815-0004 80.5 µM 0.832174415220937 0.188881102454427 no 625 0.202655251483667 983 642433
SGTC_2178 5812956 200 µM 0.831486646079401 0.189079173013734 no 626 0.202849384519623 1024 5403383
SGTC_1835 st008666 49.2 µM 0.831396223784861 0.189105223232013 no 627 0.202874915813097 893 690455
SGTC_66 0109-0187 42.4 µM 0.828204700929802 0.190026100626187 no 628 0.203777291011977 907 759417
SGTC_1410 3909-8106 77.9 µM 0.827805070993681 0.190141603128247 no 629 0.203890451196639 1016 1039210
SGTC_301 4119-0100 24.5 µM 0.825418052375758 0.190832405981642 no 630 0.204567144725683 1011 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_948 3448-0295 75.3 µM 0.823364765080687 0.191427857345271 no 631 0.205150296892883 1014 678569
SGTC_2249 haloperidol 116.36 µM 0.822713555445316 0.191616945066051 no 632 0.205335452453944 1086 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1795 st049545 62.3 µM 0.822446782937162 0.191694439172974 no 633 0.205411331355151 1013 5291882
SGTC_2489 cantharidin 73.42 µM 0.820556968774781 0.1922439561531 no 634 0.2059493334903 1010 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_632 0781-2353 4.65 µM 0.819176007166686 0.192646118505533 no 635 0.206343000840812 1030 6811515 YHR007C ERG11
SGTC_1025 k007-0731 70 µM 0.817946420536969 0.193004629931205 no 636 0.206693891103994 1014 6256118
SGTC_3137 9097352 49.47 µM 0.817026707716947 0.193273057395052 no 637 0.206956582720402 1077 44120435
SGTC_1043 0916-0009 19.3 µM 0.816218764963343 0.193509051525822 no 638 0.207187513109103 1111 3101130
SGTC_3038 9091290 49.47 µM 0.815731528034397 0.193651454770576 no 639 0.207326851334743 1003 25236843
SGTC_273 hydroxyurea 18.1 mM 0.815548626623619 0.193704927297837 no 640 0.207379171107678 1073 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2426 5582046 32.21 µM 0.814944787154426 0.193881527971411 no 641 0.207551957524734 1011 2251934
SGTC_3019 9081971 49.47 µM 0.814054802445637 0.194141994358414 no 642 0.207806778382386 1060 16451803
SGTC_3282 9108498 15.4605 µM 0.81222848451297 0.194677158731267 no 643 0.208330268898481 960 16459645
SGTC_2436 5633522 8.09 µM 0.809781337759485 0.195395649483014 no 644 0.209032930163008 1047 5724242
SGTC_3112 9123419 49.47 µM 0.809476454708184 0.195485276907179 no 645 0.209120570403199 1087 17015854
SGTC_1643 st009866 20.2 µM 0.809245010795582 0.195553331866452 no 646 0.209187114619544 1045 3156273 YOR207C RET1
SGTC_387 norethindrone acetate 66.7 µM 0.808569885660602 0.195751931312153 no 647 0.209381296236145 968 541197
SGTC_1734 st037168 69.4 µM 0.808320323653912 0.195825375165594 no 648 0.209453102889035 965 708907
SGTC_3351 9150312 21.596 µM 0.806821749089 0.196266743774128 no 649 0.209884593430465 1006 4904905
SGTC_2277 7947813 106.88 µM 0.804993691641182 0.196805969386542 no 650 0.210411660058382 992 1246798
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.804662496606967 0.196903758522784 no 651 0.210507233479892 1003 688662
SGTC_414 piperonyl butoxide 100 µM 0.802692536762884 0.197486019412471 no 652 0.211076233842805 1018 5794 A potent inhibitor of cytochrome P450.
SGTC_2143 5623677 140.463 µM 0.799826470533201 0.198334999146123 no 653 0.211905672093325 1030 5375313
SGTC_2171 5739187 198.077 µM 0.798854832513518 0.198623314771687 no 654 0.212187295866179 1009 2262761
SGTC_1355 1499-0035 1.68 µM 0.798736512440216 0.198658441323145 no 655 0.2122216052069 1020 1548538
SGTC_2011 4012611 177 µM 0.797032467121291 0.199164749192893 no 656 0.212716087773561 1069 2049887
SGTC_2687 chenodiol 100 µM 0.796742243774218 0.199251058081924 no 657 0.212800372235194 991 5702181 A cholesterol synthesis inhibitor.
SGTC_2958 9077254 16.72 µM 0.79660622110977 0.199291517317352 no 658 0.212839881613627 1042 16457351
SGTC_2698 st077697 67.5 µM 0.796300874055054 0.199382359230314 no 659 0.21292858883972 983 3154499
SGTC_1116 jasmonic acid 1.58368 µM 0.795837476658871 0.199520269339823 no 660 0.213063252920986 1046 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_889 0919-1524 82.7 µM 0.795365439712995 0.199660809649897 no 661 0.213200478739741 1001 3905452
SGTC_1723 st034307 2.5525 µM 0.795019252378021 0.19976391840656 no 662 0.21330115158368 1056 867466
SGTC_1350 1495-0454 146 µM 0.794935865206495 0.199788759305156 no 663 0.21332540509215 1085 1069057
SGTC_1625 st003711 30.1 µM 0.793968226462427 0.200077153127745 no 664 0.21360696443793 1059 24207034 YER133W GLC7
SGTC_2466 5983409 37.09 µM 0.793581747748707 0.200192408653255 no 665 0.213719480826978 997 2879657
SGTC_895 0964-0006 13.7 µM 0.793130687958243 0.200326973968872 no 666 0.213850842492312 1046 6738897
SGTC_3232 9132874 49.47 µM 0.793087684623272 0.200339806052468 no 667 0.213863368762402 1041 3784940
SGTC_1236 0330-0013 258 µM 0.791902626408545 0.200693618627242 no 668 0.214208727721744 1011 4617066
SGTC_1010 4112-3296 15.2 µM 0.791581189586986 0.200789651868377 no 669 0.214302459272508 1098 704384
SGTC_1860 st056228 74.6 µM 0.788797722066678 0.201622400215735 no 670 0.215115120555296 1058 688679
SGTC_2837 9008476 45.46 µM 0.786047689808632 0.202447173942576 no 671 0.215919774263677 1052 2992805
SGTC_713 1488-1073 324 µM 0.785475114499012 0.202619150800485 no 672 0.216087527697072 1065 3312542
SGTC_3307 9126885 69.2785 µM 0.785272403927713 0.202680057211217 no 673 0.216146936041782 1047 24824909
SGTC_248 streptozotocin 5.23457 mM 0.782798707599529 0.203424184954898 no 674 0.216872663318503 1108 5300 DNA alkylating agent.
SGTC_1218 1348-1416 30.7 µM 0.782434630290031 0.20353384271362 no 675 0.216979594265741 1084 6787668
SGTC_81 0411-0046 9.971 µM 0.781874784521078 0.203702533455755 no 676 0.217144082624747 973 12925265
SGTC_1771 st048882 4.1505 µM 0.781742134512057 0.203742515298159 no 677 0.217183067095516 1080 4580403
SGTC_188 3229-0966 278.469 µM 0.780826927112498 0.204018494067356 no 678 0.217452147274931 1179 5722370
SGTC_873 0591-4978 488 µM 0.780728565612721 0.204048168009187 no 679 0.217481077994375 1126 3305145
SGTC_1289 0976-0073 69.1 µM 0.780613366438385 0.204082924851476 no 680 0.217514963944198 1076 3391136
SGTC_11 0438-0307 1.3 µM 0.780550761967445 0.204101814779411 no 681 0.217533380388611 1052 4011476
SGTC_1797 st048695 56.8 µM 0.77928713015131 0.20448331870317 no 682 0.217905297089588 1059 592262 YIL048W NEO1
SGTC_937 3122-0005 46.7 µM 0.778954470031401 0.204583822867596 no 683 0.218003267760966 1089 759535
SGTC_585 0kpi-0023 191 µM 0.778497086461809 0.204722056792312 no 684 0.218138011790913 1038 64601
SGTC_2126 5251174 33.877 µM 0.776139020980157 0.205435610299894 no 685 0.218833453048768 1128 790722
SGTC_2490 carminic acid 95.39 µM 0.77554025802292 0.205617031560879 no 686 0.219010243241326 1034 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1223 0764-0573 147 µM 0.775478196983778 0.205635841087981 no 687 0.219028572022915 1123 1609797
SGTC_2972 9093619 59.92 µM 0.77313393757722 0.206347089447587 no 688 0.219721559026444 1038 25236256
SGTC_1269 0831-0796 3.05 µM 0.773118763077486 0.206351698134971 no 689 0.219726048860129 1087 927758
SGTC_2688 kanamycin b 96.69 µM 0.771788284536795 0.206756018378174 no 690 0.220119915815425 1274 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2397 5161689 200 µM 0.771172175562929 0.206943407029022 no 691 0.220302442146272 1068 2259942
SGTC_331 k048-0133 24.5 µM 0.771012347351732 0.206992034961219 no 692 0.220349806475001 1072 6813582
SGTC_3020 9089140 49.47 µM 0.76961948535935 0.207416101096739 no 693 0.220762821521737 1107 17217859
SGTC_2416 tofa 880 nM 0.769470267309771 0.207461561965857 no 694 0.220807094320465 977 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2824 7998404 51.95 µM 0.769446536618581 0.207468792316602 no 695 0.22081413565381 1027 837851
SGTC_2177 5811945 192 µM 0.768948400455981 0.207620600575921 no 696 0.220961971505538 1104 5343475
SGTC_2536 dehydroabietamide 32.04 µM 0.765958015326035 0.208533306769895 no 697 0.221850642040154 1101 3983547
SGTC_2782 7736369 71.43 µM 0.764213506826731 0.209066845316884 no 698 0.222370009390013 1130 2950836 YOL077C BRX1
SGTC_1921 5740136 50 µM 0.762115558649233 0.209709542958701 no 699 0.222995518832655 1103 1774243
SGTC_1594 piperine 70.1 µM 0.762089486460098 0.20971753736622 no 700 0.223003298631911 1072 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.761543670822388 0.209884939696997 no 701 0.223166202534241 1075 688667
SGTC_43 0570-0105 72.5 µM 0.758699513394047 0.210758516348236 no 702 0.22401616403143 1131 1114046 YDL195W SEC31
SGTC_416 estradiol valerate 100 µM 0.757751382327143 0.211050206018384 no 703 0.224299916220885 1102 13791 A steroid.
SGTC_1330 1469-0054 61.8 µM 0.756275891008514 0.211504606835835 no 704 0.224741899882049 1138 7102664
SGTC_3114 9122766 49.47 µM 0.753440253679974 0.212379492642178 no 705 0.225592700633128 1028 17176985
SGTC_645 0845-0943 5.41 µM 0.752924908884016 0.212538719950492 no 706 0.225747519470932 1062 1885106
SGTC_300 r073-0011 5.04 µM 0.752518409607175 0.212664366178677 no 707 0.22586968154825 1151 2735780
SGTC_2952 9073731 13.78 µM 0.751578686406137 0.212954994359462 no 708 0.226152232333846 1168 16457353
SGTC_2930 9013230 14.89 µM 0.751515503687953 0.21297454318951 no 709 0.226171236928351 1106 2995857
SGTC_106 0092-0003 11.579 µM 0.751482579791173 0.212984730308717 no 710 0.226181140394401 1065 1072148
SGTC_180 1486-1293 102.781 µM 0.751007815128343 0.213131660816325 no 711 0.22632397623799 1122 4140536
SGTC_1226 3909-7979 35.4 µM 0.74952330689346 0.213591468775795 no 712 0.226770928173528 1125 6615510
SGTC_1977 st070720 65.3 µM 0.747922985892245 0.21408779508386 no 713 0.227253306038333 1079 682188
SGTC_2331 7980721 200 µM 0.745422693147688 0.214864582194001 no 714 0.228008114699886 1110 2981221
SGTC_3236 9132701 49.47 µM 0.745287565214187 0.214906610113476 no 715 0.228048948342578 1110 24282524
SGTC_464 bw-b 70c 158 µM 0.74523246618487 0.214923748559086 no 716 0.228065599626411 1146 5353454
SGTC_2846 9008642 19.48 µM 0.744936735260201 0.215015748649912 no 717 0.228154983111688 1095 2992898
SGTC_2986 9022445 71.43 µM 0.744123336714653 0.215268909904214 no 718 0.228400931121809 1090 6459286
SGTC_1567 st069303 68.4 µM 0.743062971170693 0.215599196489223 no 719 0.228721778334536 1138 5581319
SGTC_1758 st042942 75.2445 µM 0.742172793705162 0.215876699017059 no 720 0.228991325027919 1118 669317
SGTC_2504 purpurogallin 52.29 µM 0.74120874105112 0.216177464611387 no 721 0.229283442132706 1052 5281571 An antioxidant.
SGTC_399 oxolinic acid 75 µM 0.741080178221501 0.216217592031767 no 722 0.229322413672963 1088 4628 A DNA gyrase inhibitor.
SGTC_2594 a-mangostin 100 µM 0.739597324149295 0.216680736596262 no 723 0.229772182902977 1126 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_683 panaxydol 45 µM 0.738423418829703 0.217047792780657 no 724 0.230128593926593 1121 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2859 9028643 45.46 µM 0.73807437607454 0.217157000572534 no 725 0.230234626905716 1097 17151580
SGTC_1877 wortmannin 25 µM 0.737761482821917 0.217254924958329 no 726 0.230329701531336 1150 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.737375693823098 0.21737569820504 no 727 0.230446956213248 1125 7104
SGTC_1919 st067113 52.3 µM 0.73659065572902 0.217621578118343 no 728 0.230685659570792 1110 1268243
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.734408082980895 0.218306019300845 no 729 0.231350030973251 1151 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_770 0389-1121 67.2 µM 0.73414759584188 0.218387789197018 no 730 0.231429394030208 1177 6753108
SGTC_3308 9128332 17.569 µM 0.732919085976482 0.218773670233369 no 731 0.231803890763102 1161 17332805 YDL196W YDL196W
SGTC_507 nimesulide 162 µM 0.731397883282891 0.219252030826162 no 732 0.232268078903718 1129 4495 A COX2 inhibitor.
SGTC_2766 oltipraz 83.91 µM 0.731139563687228 0.219333322221728 no 733 0.23234695530241 1104 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3031 9088762 49.47 µM 0.730087028717618 0.219664726731924 no 734 0.232668494784259 1131 205253
SGTC_2252 omeprazole 400 µM 0.727866970225687 0.220364683448204 no 735 0.233347511985151 1069 4594 A proton pump inhibitor.
SGTC_3017 9080681 49.47 µM 0.727172183280604 0.220584003491137 no 736 0.233560242108278 1124 16451914
SGTC_278 4092-0821 23.9 µM 0.725801075567905 0.221017181157594 no 737 0.23398036373634 1149 877900
SGTC_3179 9107801 49.47 µM 0.725742024521251 0.221035848239118 no 738 0.233998466987834 1166 4818259
SGTC_2961 9083290 32.55 µM 0.725553771361567 0.221095364419447 no 739 0.234056184849194 1100 17741490
SGTC_3203 9113543 49.47 µM 0.725288719821259 0.221179175927219 no 740 0.234137462231094 1134 17018012
SGTC_1077 5-fluorocytosine 377 nM 0.725097525555808 0.221239644431418 no 741 0.234196101168761 1114 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_500 h-89 112 µM 0.724004606475021 0.221585480526136 no 742 0.234531453519024 1173 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2379 9035213 200 µM 0.722904723499819 0.221933831948343 no 743 0.234869210681674 1171 646551
SGTC_2225 6654152 15.4 µM 0.722406755528118 0.222091649558914 no 744 0.235022217359144 1119 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_102 gallobenzophenone 83.616 µM 0.721938516408243 0.222240103825903 no 745 0.235166139707944 1163 70837
SGTC_1979 st071809 45.3 µM 0.721567577293276 0.22235774950815 no 746 0.235280189562364 1168 4976333
SGTC_1487 3970-0795 2.82 µM 0.719543186706902 0.22300042340999 no 747 0.23590315145206 1177 3765103
SGTC_318 1488-0629 67.2 µM 0.719260531140167 0.223090240855916 no 748 0.235990204791308 1151 3662576
SGTC_1245 0418-0076 17.2 µM 0.71824603183365 0.223412780665774 no 749 0.236302799903517 1134 6790114
SGTC_246 cycloheximide 667 µM 0.716586676697802 0.223940910979698 no 750 0.236814583888625 1068 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2678 equilin 100 µM 0.715656407853476 0.22423730182825 no 751 0.237101767003109 1190 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3322 9139058 2.11 µM 0.715467606612443 0.224297482542222 no 752 0.237160075148571 1163 4908926 YPR165W RHO1
SGTC_2521 angolensin 13.4 µM 0.715109625265485 0.224411614871739 no 753 0.237270653401732 1181 821428 A flavenoid.
SGTC_2437 5741531 144.16 µM 0.714721579469174 0.224535369630357 no 754 0.237390550357129 1213 2262990
SGTC_3012 9080433 71.4286 µM 0.714656909098797 0.224555997934116 no 755 0.23741053520243 1181 17688859
SGTC_1556 plumbagin 1.48 µM 0.711886054705192 0.225440843679798 no 756 0.238267669148771 1101 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1338 1486-1223 76 µM 0.711461025974301 0.225576746915148 no 757 0.238399296998134 1172 3444526
SGTC_76 0433-0009 400.328 µM 0.711292189679694 0.225630745302879 no 758 0.238451595237252 1081 2841569
SGTC_2937 9044753 11.33 µM 0.711198961427082 0.225660565339472 no 759 0.238480476041097 1198 6465530 YGL099W LSG1
SGTC_1588 farnesol 29.9 µM 0.710391481770039 0.225918939473781 no 760 0.238730702011719 1178 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2552 juarezic acid 87.02 µM 0.710357063742523 0.225929956133132 no 761 0.238741370838943 1254 1549512
SGTC_1305 1181-0477 144 µM 0.710143300985925 0.225998384969 no 762 0.238807638405885 1156 6252086
SGTC_420 mitomycin C 81.9 mM 0.708113395222638 0.226648773480393 no 763 0.239437420906924 1180 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_938 3126-1755 342 µM 0.707768303526755 0.226759446965804 no 764 0.239544576455957 1209 1777771
SGTC_1059 3448-6867 171 µM 0.705808110187163 0.227388673825836 no 765 0.240153738912718 1174 3934407
SGTC_1527 coumarin 137 µM 0.70561417287041 0.227450981607198 no 766 0.2402140540048 1154 323 A hepatotoxic, DNA x-linker.
SGTC_2629 bisabolol 100 µM 0.705011040710936 0.227644816110114 no 767 0.240401682677638 1174 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1479 0549-0158 134 µM 0.70431033871632 0.227870124324468 no 768 0.240619764602576 1239 5440202
SGTC_2302 7771753 200 µM 0.701094996665364 0.228905613374104 no 769 0.241621866281401 1184 2203047
SGTC_2259 7964009 200 µM 0.700457098656515 0.229111359540654 no 770 0.241820944206902 1198 313134
SGTC_2041 5107442 45.335 µM 0.7000891721535 0.229230076866739 no 771 0.241935808736444 1202 793005
SGTC_730 1436-0052 41.2 µM 0.698922427103829 0.229606773714311 no 772 0.242300255467389 1219 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1151 3909-8316 15.3 µM 0.698281022983542 0.229814005926732 no 773 0.242500732358548 1211 800431
SGTC_27 0485-0001 32.618 µM 0.697412276694571 0.230094857365242 no 774 0.242772410375121 1133 2054479
SGTC_1654 st012436 41.8 µM 0.697214026173671 0.230158975411209 no 775 0.242834431195323 1165 4323132
SGTC_1404 3909-7820 48.3 µM 0.696909798321155 0.230257388007241 no 776 0.242929622704221 1172 23741373
SGTC_2086 5274770 176.623 µM 0.69575574194887 0.230630919727765 no 777 0.243290905157034 1196 689278
SGTC_2799 7812892 81.82 µM 0.69190594978065 0.231879421631511 no 778 0.244498196981722 1196 20205235
SGTC_2310 7668677 200 µM 0.691867030438044 0.231892062509439 no 779 0.244510418514471 1230 2197143
SGTC_291 SEC14.278 35.5 µM 0.691760097912728 0.231926795827281 no 780 0.244543999382261 1210 1068044
SGTC_1810 st050138 53 µM 0.691747567967287 0.231930865934606 no 781 0.244547934422858 1203 3444541
SGTC_1871 st057448 67.3 µM 0.691746011167143 0.231931371633414 no 782 0.244548423339721 1284 691747
SGTC_1862 st057513 3.81 µM 0.689740328276696 0.23258339176831 no 783 0.24517874999874 1194 5393163
SGTC_309 k408-0051 1.48 µM 0.688306833802947 0.233050025015684 no 784 0.245629789582467 1194 3640463
SGTC_2772 vinpocetine 57.06 µM 0.687840169349625 0.23320204641276 no 785 0.245776718567388 1231 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3071 9117417 49.47 µM 0.687749903495739 0.233231457921068 no 786 0.245805144154911 1140 45595590 YGL055W OLE1
SGTC_671 0560-0003 407 µM 0.687407742237121 0.233342963716944 no 787 0.245912910055542 1150 3238678
SGTC_1782 st039423 80.636 µM 0.685941308786723 0.233821189736859 no 788 0.246375059806555 1191 2068169
SGTC_1525 8-methoxypsoralen 92.5 µM 0.684933402441601 0.234150197870242 no 789 0.246692973452683 1247 4114 Related to psoralen; DNA damaging agent.
SGTC_169 k015-0017 16.025 µM 0.684383572608354 0.234329785335141 no 790 0.246866493245773 1258 1840002
SGTC_1398 3558-0053 112 µM 0.684358802122204 0.234337877757602 no 791 0.246874312055825 1136 4532369
SGTC_3175 9106517 49.47 µM 0.683892044483789 0.23449039459415 no 792 0.247021668996582 1206 41468073
SGTC_2022 5136654 200 µM 0.683620876176928 0.23457902624666 no 793 0.247107299340322 1206 1713771
SGTC_617 3770-0098 35 µM 0.681420922832526 0.235298767882183 no 794 0.247802593774379 1176 5962639
SGTC_1386 3228-0095 33.8 µM 0.679605624221668 0.235893581877007 no 795 0.248377103767962 1205 870181
SGTC_1346 1488-2224 62.4 µM 0.67870786792774 0.23618805328092 no 796 0.248661489961179 1225 3722427
SGTC_2105 5350118 200 µM 0.678221278684367 0.236347743100178 no 797 0.248815701408818 1240 2133313
SGTC_1942 st076330 65.2 µM 0.677966311188179 0.236431442565047 no 798 0.248896526862689 1261 24208414
SGTC_2172 5754775 163.918 µM 0.677694615902864 0.236520651298895 no 799 0.24898267045313 1160 2263357
SGTC_2069 5228469 200 µM 0.677449588897632 0.236601119622427 no 800 0.24906037221391 1191 2835210
SGTC_1749 st037932 54.2 µM 0.677086420236341 0.236720414069295 no 801 0.249175562203299 1208 594497
SGTC_2197 6588183 93.1375 µM 0.676629058453704 0.236870696336018 no 802 0.249320668707863 1202 884136
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.676387908419102 0.236949955759362 no 803 0.249397196111289 1205 5355888
SGTC_1939 st074455 53.6 µM 0.67587874459312 0.23711735186359 no 804 0.249558816959117 1253 1644229
SGTC_2375 9072683 200 µM 0.673736174807638 0.237822468925903 no 805 0.250239529450254 1278 16798029
SGTC_1464 k208-0027 110 µM 0.673593216331726 0.237869557272259 no 806 0.250284983577053 1250 X1464
SGTC_2994 9053520 71.4286 µM 0.672613569831581 0.238192375438938 no 807 0.250596583213881 1216 4647384
SGTC_2096 5468907 200 µM 0.672292197998022 0.238298327806679 no 808 0.250698847840943 1241 759785
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.671541398990206 0.238545957640444 no 809 0.250937847791504 1275 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2658 polymyxin b sulfate 77.05 µM 0.669773738202735 0.239129526396722 no 810 0.251501018599159 1204 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1009 4106-0057 9.87 µM 0.669615805011727 0.239181703798458 no 811 0.251551368065723 1259 2928005
SGTC_781 4335-2806 94.4 µM 0.669012509227105 0.239381075760692 no 812 0.251743749172577 1316 845254
SGTC_244 nsc-207895 1.295 µM 0.666613761881428 0.240174690183618 no 813 0.252509438173082 1142 42640
SGTC_1605 st000082 49.1 µM 0.666463044183168 0.240224602270113 no 814 0.252557588757903 1262 1114022
SGTC_164 4100-3994 89.624 µM 0.664014452191993 0.241036276056772 no 815 0.253340530642945 1270 4615967
SGTC_2771 fluoxetine 41.05 µM 0.663430425351131 0.241230092769971 no 816 0.253527462595983 1254 3386 A selective serotonin reuptake inhibitor.
SGTC_3018 9082602 49.47 µM 0.662522112427379 0.241531696163053 no 817 0.253818334107908 1243 17332089
SGTC_1314 1222-0010 41.1 µM 0.661316697335994 0.241932267705561 no 818 0.254204617796585 1251 3526027
SGTC_2295 7971645 200 µM 0.66104038021751 0.242024141406669 no 819 0.25429320896037 1258 2978226 YKL099C UTP11
SGTC_886 0866-0150 153 µM 0.660181954749952 0.242309683128934 no 820 0.254568535483927 1274 271463
SGTC_1779 st039427 55 µM 0.658348326792636 0.242920221599041 no 821 0.255157165540085 1302 1124498
SGTC_936 3005-4620 401 µM 0.65826807936458 0.242946960378751 no 822 0.255182942764666 1283 777207
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.656849091363324 0.243420036035529 no 823 0.255638977506083 1274 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_350 k064-0020 19.8 µM 0.654434056030168 0.244226326458458 no 824 0.256416099689601 1260 2790705
SGTC_1829 berberine 14.4 µM 0.654324898142847 0.244262804194557 no 825 0.256451254116668 1308 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_252 miconazole 1.30953 nM 0.652670024356662 0.244816179721823 no 826 0.256984515635481 1218 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1502 4534-4282 27.7 µM 0.651723241070957 0.245133079101402 no 827 0.257289863432641 1262 3278949
SGTC_2835 9006588 71.43 µM 0.651071019441442 0.245351513533496 no 828 0.257500321572469 1269 2345538
SGTC_2456 5770359 74.46 µM 0.649432929913758 0.245900584316779 no 829 0.258029292517807 1276 3118787
SGTC_2297 7971671 152.32 µM 0.648193460433035 0.246316479608342 no 830 0.258429915534663 1308 909016
SGTC_716 1683-5115 658 µM 0.647869483416197 0.246425249952127 no 831 0.258534684924504 1293 723597
SGTC_2481 5478948 45.16 µM 0.647502231623351 0.246548580262598 no 832 0.258653475333982 1273 77792
SGTC_3345 9148410 3.559 µM 0.645121508660533 0.247348874774631 no 833 0.259424223200705 1236 4903596
SGTC_3223 9129970 49.47 µM 0.644378326378049 0.247598984119346 no 834 0.259665067719002 1329 17248386
SGTC_1811 st050069 61.5 µM 0.643186981828076 0.248000198944388 no 835 0.260051389712397 1263 3877702
SGTC_2988 9073640 71.4286 µM 0.642713097296552 0.248159887698674 no 836 0.260205140460481 1310 9102229
SGTC_2796 7949634 45.45 µM 0.642629324008842 0.24818812317326 no 837 0.260232325383487 1260 2971588
SGTC_1988 st071872 53.4 µM 0.642305523357296 0.248297275084245 no 838 0.260337414353246 1293 16414116
SGTC_2223 6903751 107.57 µM 0.641267683860305 0.248647299057066 no 839 0.260674390734538 1254 5598863
SGTC_385 1494-0393 12.4 µM 0.640662129364033 0.248851651008981 no 840 0.260871112035879 1300 3090647
SGTC_286 k060-0067 22.9 µM 0.639424070869281 0.249269727448975 no 841 0.261273547016755 1246 5985051
SGTC_817 1391-0715 46 µM 0.637889118853378 0.249788579102069 no 842 0.261772930690276 1249 1353946
SGTC_2830 7992007 71.43 µM 0.637714944109433 0.24984749066649 no 843 0.261829627889957 1245 1952075
SGTC_3298 9116858 71.43 µM 0.637080745135427 0.250062059697676 no 844 0.262036124954086 1314 2506942
SGTC_1792 st045773 43.6 µM 0.635726766567068 0.250520479280622 no 845 0.262477263582446 1245 2919270
SGTC_1642 st009582 77.7 µM 0.635517620452083 0.250591330035915 no 846 0.262545439187365 1304 6739311
SGTC_3239 9133757 49.47 µM 0.634097121542668 0.251072821829195 no 847 0.263008720590222 1299 17036923
SGTC_2094 5332512 191.667 µM 0.63318213478617 0.251383224379929 no 848 0.263307355397969 1354 755774
SGTC_1690 st023502 41.2 µM 0.633161210676355 0.251390325102445 no 849 0.263314186666304 1275 24207482
SGTC_2976 9009005 19.48 µM 0.631250165916703 0.252039296395923 no 850 0.263938482735284 1311 2993148
SGTC_2746 daunorubicin 9.88 µM 0.63111002080221 0.252086923009784 no 851 0.263984294719869 1199 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_901 1112-0062 60.1 µM 0.631060273926231 0.25210383002265 no 852 0.264000557432235 1297 1908457
SGTC_2788 5282734 71.43 µM 0.630424386399643 0.252319995942754 no 853 0.264208479891007 1364 743706
SGTC_2079 5212404 121 µM 0.630269552388854 0.25237264556923 no 854 0.264259120128125 1320 758462
SGTC_1730 st033808 45.1 µM 0.629518256859414 0.252628197665703 no 855 0.264504910094493 1328 1045166
SGTC_422 cantharidin 155 µM 0.628867186414933 0.2528497685353 no 856 0.264718004984959 1257 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2784 7567673 72.73 µM 0.628759072800788 0.252886571425323 no 857 0.264753398943664 1310 3471247
SGTC_207 4185-0010 4.486 µM 0.628621962203397 0.252933249215826 no 858 0.264798289321213 1344 3761753
SGTC_245 methotrexate 289.6 µM 0.626407268119528 0.253687845080859 no 859 0.265523921763369 1310 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2357 9067248 200 µM 0.623150655238387 0.254799589689314 no 860 0.266592762335626 1315 9150235
SGTC_2899 9053889 58.44 µM 0.623081325505123 0.254823285214061 no 861 0.266615540413202 1285 6470052
SGTC_726 3448-4391 34.2 µM 0.622748306760292 0.254937120477115 no 862 0.266724966444646 1394 1356692
SGTC_1085 doxorubicin 7.67 µM 0.621477125688367 0.255371890796748 no 863 0.267142870149517 1323 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1521 st012942 49.4 µM 0.620945308451793 0.255553898240913 no 864 0.267317804307232 1374 24207259
SGTC_2453 5731132 22.18 µM 0.620447311574099 0.255724392527013 no 865 0.267481666094694 1377 1362040
SGTC_353 1988-1175 58.3 µM 0.619485356005856 0.256053895858689 no 866 0.267798333040774 1245 2788357
SGTC_2196 6573537 42.6665 µM 0.618706475133802 0.256320851883299 no 867 0.268054871780391 1358 2903087
SGTC_997 3996-0078 137 µM 0.617681963961992 0.256672216769 no 868 0.268392501660251 1333 735687
SGTC_3227 9130768 49.47 µM 0.616705502753491 0.257007335783097 no 869 0.268714495500095 1345 17720899
SGTC_766 1391-0721 126 µM 0.616022214710804 0.257241973795863 no 870 0.268939929121514 1369 1020919 YIL115C NUP159
SGTC_3341 9147222 25.867 µM 0.61570437295785 0.257351157146476 no 871 0.269044825321804 1300 1939759
SGTC_717 1532-0246 73.2 µM 0.614362835221423 0.257812260430395 no 872 0.269487794438046 1299 9561992
SGTC_1716 st033144 30.6155 µM 0.612641455545721 0.258404547574387 no 873 0.270056720415838 1341 674617
SGTC_1508 1080-0625 72.9 µM 0.612396424697081 0.258488914331851 no 874 0.270137753365237 1271 767111
SGTC_1429 4049-0205 9.46 µM 0.612352716041379 0.258503965191617 no 875 0.270152209318396 1347 22774478
SGTC_829 1635-0120 117 µM 0.611324999911031 0.258857984928535 no 876 0.270492221795834 1349 285054
SGTC_2985 9022375 71.43 µM 0.611295140014174 0.258868274584637 no 877 0.270502103923149 1342 4939335
SGTC_2068 5226020 147 µM 0.60877530884461 0.259737364803493 no 878 0.271336690926077 1322 1810509
SGTC_2015 5119600 184 µM 0.604843348383746 0.261096500465057 no 879 0.272641543971641 1366 2828786
SGTC_2050 5263056 171 µM 0.603496884931583 0.261562762751908 no 880 0.273089093595529 1323 763468 YGL055W OLE1
SGTC_2394 5221648 200 µM 0.600426184701539 0.262627701732433 no 881 0.274111120682311 1449 788586
SGTC_1321 1326-2144 215 µM 0.600167951564228 0.262717359707772 no 882 0.2741971549768 1329 3513030
SGTC_773 4358-1457 44.6 µM 0.599890580607726 0.262813679730448 no 883 0.274289580180436 1355 1186886
SGTC_1755 st041960 45.185 µM 0.599199783096445 0.26305364500883 no 884 0.274519833705587 1355 2257073
SGTC_2469 5655019 90.81 µM 0.596844145891367 0.263872773857128 no 885 0.275305720479512 1446 2788239
SGTC_2342 7990637 118.86 µM 0.596353857225837 0.264043425930575 no 886 0.275469429503331 1388 2033102 YER133W GLC7
SGTC_88 0180-0332 8.668 µM 0.594916979674836 0.264543875680021 no 887 0.275949483363519 1373 3101745
SGTC_1395 3486-0190 4.35 µM 0.593586822701694 0.265007585518521 no 888 0.276394248338814 1410 6748079
SGTC_2175 5807670 165.306 µM 0.592825136847354 0.265273304834822 no 889 0.276649091675379 1307 241186
SGTC_1033 k072-0102 21.3 µM 0.591135692452186 0.265863161392576 no 890 0.277214753251591 1341 5965931
SGTC_1240 0356-0016 42.1 µM 0.591043186832367 0.265895478203674 no 891 0.277245742412684 1373 4305613
SGTC_2064 5220758 200 µM 0.591018409794829 0.265904134392419 no 892 0.277254042948618 1378 788518
SGTC_1276 0871-0068 94.2 µM 0.590927965167261 0.265935733642074 no 893 0.277284343764101 1373 3414906
SGTC_53 0973-0023 39.979 µM 0.589607369086837 0.266397335798158 no 894 0.277726955060341 1342 674768
SGTC_2519 cryptotanshinone 88.04 µM 0.58865367454918 0.266730942816115 no 895 0.278046809969861 1353 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2248 tofa 1.1 µM 0.588378022396603 0.266827406610261 no 896 0.278139293055226 1362 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2721 ifenprodil 61.44 µM 0.587097596930961 0.267275719353606 no 897 0.278569080706447 1374 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1560 lithocholic acid 53.1 µM 0.586744200729513 0.267399520135978 no 898 0.278687758618701 1325 9903 A bile acid which acts as a detergent.
SGTC_2313 7726885 200 µM 0.583622622870568 0.268494317337475 no 899 0.279737118126109 1357 726423
SGTC_2381 9035592 200 µM 0.582577638585129 0.268861316157373 no 900 0.280088831189364 1302 4749657
SGTC_1630 st005209 31.3 µM 0.582402949333254 0.268922691645829 no 901 0.280147647704586 1378 3367314
SGTC_1466 k213-0079 57.5 µM 0.581538188560503 0.269226621085375 no 902 0.280438894056743 1348 3657981
SGTC_1246 0422-0085 105 µM 0.580484268896353 0.269597265250808 no 903 0.280794046075053 1367 264295
SGTC_231 b-estradiol 524 µM 0.577494643061208 0.270650050983959 no 904 0.281802678183664 1315 450 A steroid.
SGTC_570 0987-0065 62.6 µM 0.577401483561178 0.270682889715253 no 905 0.281834136123549 1290 3104428
SGTC_2246 7293507 91.5585 µM 0.577165022075414 0.270766251341553 no 906 0.281913991629984 1411 887656
SGTC_1881 5652484 16 µM 0.576057158821078 0.271156985693788 no 907 0.282288273696189 1370 2255129
SGTC_622 1348-1566 26.3 µM 0.575580697317969 0.271325116204687 no 908 0.282449315610813 1441 7340407
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.575565059182533 0.271330635364554 no 909 0.282454601981332 1424 688751
SGTC_2398 5228213 48.84 µM 0.575043249555397 0.271514829468073 no 910 0.28263102362747 1423 80771 YMR134W ERG29
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.572763461921201 0.272320303718659 no 911 0.283402430816673 1438 94937 An inhibitor of serotonin biosynthesis.
SGTC_3301 9125354 19.7965 µM 0.572157888901154 0.272534458761199 no 912 0.283607506888919 1366 41905162
SGTC_2451 5856223 45.7 µM 0.571890846455617 0.27262892229861 no 913 0.283697962852679 1348 2179896
SGTC_1389 3405-0187 19 µM 0.571873135244598 0.272635188033217 no 914 0.283703962704612 1327 799890
SGTC_478 N-arachidonylglycine 10 µM 0.571130517535002 0.272897969863736 no 915 0.283955586644803 1353 5283389
SGTC_975 1335-0046 28.5 µM 0.570108970388234 0.273259658456321 no 916 0.284301895685984 1312 16486740
SGTC_2551 apiole 73.87 µM 0.569897176219632 0.273334675927546 no 917 0.28437372011204 1323 10659 A possible DNA adduct former.
SGTC_1333 1482-0047 286 µM 0.569815047248755 0.273363768744123 no 918 0.284401574326995 1349 3811116
SGTC_2933 9026794 32.47 µM 0.56926583437969 0.27355835763658 no 919 0.284587874537484 1433 17586027
SGTC_2700 st077718 96.8 µM 0.568138654868376 0.273957937622822 no 920 0.284970411045023 1388 904970
SGTC_1863 st057641 20.1 µM 0.567356913805378 0.274235230573619 no 921 0.285235858321899 1374 3921635
SGTC_808 0711-0032 135 µM 0.567071558128502 0.274336484182449 no 922 0.285332782776931 1382 4252555
SGTC_1091 telmisartan 47.6 µM 0.566586619498957 0.274508598730604 no 923 0.285497533934256 1448 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_564 3555-0129 330 µM 0.565851581926723 0.274769580004261 no 924 0.28574733903907 1326 563260
SGTC_2906 7926292 26.41 µM 0.563145332237545 0.275731509711436 no 925 0.286667962468978 1378 2966319
SGTC_2 0422-0095 29 µM 0.562614766521179 0.27592029185251 no 926 0.286848617320011 1278 6790840
SGTC_362 0310-0100 9.03 µM 0.561871375180757 0.276184906855719 no 927 0.287101828900277 1403 790235
SGTC_132 0417-1715 25.805 µM 0.561302786780192 0.276387383639283 no 928 0.287295571065882 1477 6769098
SGTC_1550 gossypolone 36.6 µM 0.561159591923935 0.276438387420118 no 929 0.287344373372385 1379 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2648 atorvastatin 78.68 µM 0.560720042576273 0.276594976885567 no 930 0.287494200884647 1418 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3054 9094397 49.47 µM 0.559557109651205 0.277009481331861 no 931 0.287890783465013 1352 2598354
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.558484321295613 0.277392124960785 no 932 0.288256853926044 1336 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_287 k060-0039 29.6 µM 0.557486752266054 0.277748170973572 no 933 0.288597453956466 1473 5861974
SGTC_2491 paeonol 100 µM 0.556932513819014 0.277946082641381 no 934 0.28878676950169 1354 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1028 k015-0029 4.8 µM 0.556529174754364 0.278090153268023 no 935 0.288924577914189 1397 4588309
SGTC_669 0108-0021 26.2 µM 0.556089982929916 0.278247071732999 no 936 0.289074671283552 1634 17201
SGTC_798 1287-0182 476 µM 0.554815408837489 0.278702707490629 no 937 0.289510463223692 1458 1649755
SGTC_3199 9111318 49.47 µM 0.554035817951789 0.278981575179387 no 938 0.289777166534592 1444 8548020
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.553743397733525 0.279086211894382 no 939 0.289877235188237 1467 551469
SGTC_2744 captopril 92.04 µM 0.553127885694336 0.279306522880572 no 940 0.290087921521777 1468 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2140 5586273 200 µM 0.551869672709172 0.279757139364239 no 941 0.290518823957812 1400 854421
SGTC_887 0885-0007 9.62 µM 0.550735911004656 0.28016348674306 no 942 0.290907361722099 1464 5719458
SGTC_329 k048-0121 21.3 µM 0.550436227246287 0.280270943069112 no 943 0.291010103284712 1407 6832902
SGTC_2202 7226349 200 µM 0.550096327920587 0.280392843475824 no 944 0.291126652595055 1382 844334
SGTC_896 0964-0007 44.5 µM 0.549349205956844 0.280660879099076 no 945 0.291382912538538 1395 6756758
SGTC_3343 9148379 18.9835 µM 0.548517178654978 0.280959520953242 no 946 0.291668418490636 1521 1955036
SGTC_2803 7707263 71.43 µM 0.546698210129543 0.281612942708975 no 947 0.29229304204293 1409 2199229
SGTC_2467 5474540 200 µM 0.546361613857195 0.281733937326432 no 948 0.292408695490476 1380 5413519
SGTC_2055 5235184 200 µM 0.545712171930648 0.2819674598393 no 949 0.292631901851614 1429 2836034
SGTC_84 0443-0269 128.823 µM 0.545491818113347 0.282046714549291 no 950 0.292707653121758 1372 6150058
SGTC_1791 st048313 56.1 µM 0.545264798504383 0.282128377963807 no 951 0.292785705421582 1431 1204976
SGTC_2221 6807166 181.081 µM 0.54490215830088 0.282258850381549 no 952 0.292910405892805 1413 674925
SGTC_3064 1327-0027 10 µM 0.544805801423053 0.282293522999444 no 953 0.292943544113265 1342 16000455 YPR107C YTH1
SGTC_1806 st050005 60.3 µM 0.544125178408101 0.282538493616331 no 954 0.293177667599599 1382 5194765
SGTC_1903 st060211 78.3 µM 0.543563632971119 0.282740682611793 no 955 0.293370895588304 1454 688960
SGTC_3260 9137109 49.47 µM 0.543396234987226 0.282800969063231 no 956 0.293428508710692 1414 17478346
SGTC_487 nimodipine 119 µM 0.543003083748568 0.282942582219228 no 957 0.293563839611483 1374 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3106 9121286 49.47 µM 0.54130356049001 0.283555142245935 no 958 0.294149183386391 1452 15943471
SGTC_1524 corynanthine 62.1 µM 0.540996483559716 0.283665889883104 no 959 0.294255003233677 1482 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1912 st060209 90.8 µM 0.540642219031737 0.283793681512896 no 960 0.294377105942479 1379 688787
SGTC_1656 st012921 11 µM 0.540304439213111 0.283915552380341 no 961 0.294493548724711 1436 6732821
SGTC_1319 1306-0155 43.7 µM 0.539786037211881 0.284102640386832 no 962 0.294672298698445 1449 3122360
SGTC_2187 6125751 200 µM 0.539744115576232 0.284117772216845 no 963 0.294686755866569 1429 874498
SGTC_1981 st071826 47 µM 0.538128251038627 0.284701320400371 no 964 0.295244254858196 1394 11838600
SGTC_503 tyrphostin 8 294 µM 0.53753207074216 0.284916767446793 no 965 0.295450069084418 1437 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1983 st071813 46.9 µM 0.535674076451284 0.285588705973275 no 966 0.296091911478662 1420 11838595
SGTC_1079 idarubicin 2.36 µM 0.535487587145262 0.285656190944225 no 967 0.296156369356207 1420 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_109 0132-0036 33.701 µM 0.534258399682593 0.286101187293759 no 968 0.296581384794189 1350 67274 A color developer.
SGTC_2511 berberine 10.47 µM 0.532610826728578 0.286698165632758 no 969 0.297151502983861 1428 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2745 rifampicin 24.3 µM 0.532512158133047 0.286733935753649 no 970 0.297185661683781 1477 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1433 4060-0023 7.6 µM 0.531796403001953 0.286993480296095 no 971 0.297433507160722 1468 3840627
SGTC_3202 9113761 49.47 µM 0.531505681842214 0.287098932323607 no 972 0.297534202512812 1593 4798415
SGTC_1683 st010134 710 nM 0.531168257297999 0.287221347867095 no 973 0.297651093747969 1411 3818134
SGTC_647 0140-0236 81 µM 0.529367434824723 0.28787509255493 no 974 0.298275292071787 1475 990837
SGTC_2759 disulfiram 3.38 µM 0.529311068524024 0.287895566302681 no 975 0.298294839288714 1382 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2257 7960413 200 µM 0.528521806718999 0.288182319492315 no 976 0.298568607891362 1473 2974689 YIL048W NEO1
SGTC_1100 amiodarone 5.07 µM 0.526967490594723 0.288747424468785 no 977 0.299108082178754 1476 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.525720174263641 0.289201290099628 no 978 0.299541322284978 1439 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2707 st078556 66.6 µM 0.525054962891084 0.289443480084322 no 979 0.299772491563236 1480 17250899
SGTC_1937 st074714 47.2 µM 0.523891163988486 0.289867424676415 no 980 0.300177120433806 1399 17250970
SGTC_847 0342-0274 5.54 µM 0.523300148247097 0.290082829273565 no 981 0.300382698922865 1508 18097
SGTC_1388 3346-4487 254 µM 0.521368278261975 0.290787451311311 no 982 0.301055122560855 1500 3345614
SGTC_813 k007-0158 173 µM 0.52119651368141 0.290850138712285 no 983 0.301114941278695 1534 6523916
SGTC_1457 k015-0032 57.3 µM 0.520964089215323 0.290934974671685 no 984 0.301195893929038 1448 4302660
SGTC_526 4469-0568 170 µM 0.519947502141902 0.291306169285756 no 985 0.301550082907161 1432 2901964
SGTC_1561 5-methoxyflavone 52.9 µM 0.519731934350278 0.291384909682684 no 986 0.301625212929027 1426 94525
SGTC_2399 5884133 200 µM 0.519085282426362 0.291621171635282 no 987 0.301850635552725 1437 722445
SGTC_985 1493-0307 8.71 µM 0.518173268609465 0.291954538422196 no 988 0.302168691855168 1484 3278274
SGTC_296 1222-0039 74.9 µM 0.516461793100674 0.292580609526866 no 989 0.302765958593581 1402 5984176
SGTC_2275 7947463 200 µM 0.516289630609579 0.292643622426643 no 990 0.302826068717255 1432 1225414
SGTC_1327 1436-0082 2.18 µM 0.515805631665633 0.292820803820296 no 991 0.302995084416512 1438 15992205
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.514841650233178 0.293173844566938 no 992 0.303331838938789 1519 5377381
SGTC_695 3505-6186 243 µM 0.513281112887596 0.293745781090891 no 993 0.30387734686392 1502 1819379
SGTC_1796 st049173 110.4 µM 0.512331261872817 0.294094153816342 no 994 0.304209594802095 1437 94134
SGTC_2339 9000433 200 µM 0.506032770108416 0.29640904041695 no 995 0.306416822476206 1428 2988954
SGTC_2002 4023503 131 µM 0.505797660963308 0.296495611635736 no 996 0.306499350359537 1565 4736863 YCR052W RSC6
SGTC_1394 3474-0001 65.7 µM 0.503885899922335 0.29719998457813 no 997 0.307170779743576 1441 5017666 YIL048W NEO1
SGTC_714 4296-0578 26.1 µM 0.503674003127084 0.297278103308401 no 998 0.307245239864087 1505 1589775
SGTC_2696 st077691 74.316 µM 0.503359399721319 0.297394103577213 no 999 0.307355805545431 1484 757133
SGTC_1490 4089-0339 670 nM 0.502828365209526 0.297589953006243 no 1000 0.307542474498547 1499 742542
SGTC_2827 7993847 71.43 µM 0.502661741477042 0.29765141719471 no 1001 0.307601056256071 1503 2985692
SGTC_3 0833-0587 95.581 µM 0.499979240558302 0.298641734885433 no 1002 0.308544847443542 1431 5382644
SGTC_1256 0570-0116 285 µM 0.499840983786678 0.298692816684224 no 1003 0.308593525046509 1451 410638
SGTC_2073 5212005 126 µM 0.49601219569548 0.3001090161797 no 1004 0.30994290324263 1415 691789
SGTC_3238 9133470 49.47 µM 0.495537841863092 0.300284682320964 no 1005 0.31011025845106 1566 3534688
SGTC_2430 5571206 200 µM 0.494544273176879 0.300652778400349 no 1006 0.310460923610562 1550 1731771
SGTC_2200 6600604 21.907 µM 0.49438434770354 0.300712046414266 no 1007 0.310517383016669 1442 2904777
SGTC_2966 9084041 48.03 µM 0.492542863294922 0.301394875858815 no 1008 0.311167814175394 1359 17741380
SGTC_268 camptothecin 39.6153 µM 0.491933729188551 0.301620898635927 no 1009 0.311383096571364 1497 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2876 9059903 25.97 µM 0.490814393059432 0.302036433491491 no 1010 0.311778864594686 1474 6916095
SGTC_1855 st056195 39.6 µM 0.490259444492907 0.302242544166178 no 1011 0.311975160581952 1564 4028379
SGTC_3330 9141424 71.43 µM 0.48957194980422 0.302497970624266 no 1012 0.312218414751189 1573 27261020
SGTC_2484 5809818 12.04 µM 0.488866850296565 0.302760038317109 no 1013 0.312467983039604 1502 2870548
SGTC_1587 estradiol valerate 56.1 µM 0.488814350092493 0.302779555385053 no 1014 0.312486568804457 1522 13791 A steroid.
SGTC_2044 5102272 200 µM 0.488708751479193 0.302818813611405 no 1015 0.312523953551166 1487 592666
SGTC_2414 st077232 92.9 µM 0.48657484077918 0.303612622033096 no 1016 0.31327982826969 1445 729801
SGTC_1142 3253-1408 9.78 µM 0.486486960484054 0.303645333150756 no 1017 0.31331097411669 1497 256655
SGTC_3273 9137859 49.47 µM 0.48616254170739 0.303766103089334 no 1018 0.313425963612505 1547 2377234
SGTC_587 k089-0003 57 µM 0.484091496823784 0.304537586370386 no 1019 0.314160467840084 1502 9659696
SGTC_183 3914-0051 30.55 µM 0.484020549998916 0.304564030152701 no 1020 0.314185642476611 1632 1596232
SGTC_2820 7989630 71.43 µM 0.48378783969199 0.304650774687903 no 1021 0.31426822302757 1487 2984098
SGTC_203 k066-0004 30.888 µM 0.483738597764822 0.304669131398803 no 1022 0.314285698415372 1563 6795412
SGTC_340 k038-0059 454 µM 0.481400687712108 0.305541237369641 no 1023 0.315115874004381 1539 23733424
SGTC_23 0213-0011 39.996 µM 0.481186822049831 0.305621070466142 no 1024 0.315191862936345 1578 627608
SGTC_2781 5567276 71.43 µM 0.477608397449438 0.306958215452039 no 1025 0.316464476448552 1563 2853274
SGTC_466 geldanamycin 89.2 µM 0.477228005190289 0.307100507638102 no 1026 0.316599885522472 1491 5288382 HSP90 inhibitor.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.477001405583627 0.307185284880519 no 1027 0.316680560370716 1760 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2709 st078560 56 µM 0.476631533178991 0.307323686618986 no 1028 0.316812262474605 1628 17250903
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.475291129729475 0.307825479053159 no 1029 0.317289740311389 1478 6312947
SGTC_981 1488-1094 54.9 µM 0.474962059802265 0.30794872444264 no 1030 0.317407007980928 1479 3449522
SGTC_1012 4112-3522 18 µM 0.474754732815828 0.3080263850076 no 1031 0.31748090063421 1610 3112398
SGTC_2272 7805186 180 µM 0.474591740107361 0.308087444870429 no 1032 0.317538997376509 1518 2956062 YPR165W RHO1
SGTC_1832 st054113 55 µM 0.474325703099757 0.308187118305217 no 1033 0.317633832643115 1536 1251267
SGTC_2271 7849410 118.62 µM 0.473392863402208 0.308536727787467 no 1034 0.317966460228059 1546 972430
SGTC_152 4469-0003 551.229 µM 0.472952872440961 0.308701687807538 no 1035 0.318123401137757 1535 697280
SGTC_1414 3917-0015 5.4 µM 0.472951940980032 0.308702037068889 no 1036 0.31812373341634 1523 6618702
SGTC_2405 ticlatone 3.52 µM 0.471157006697221 0.309375388229754 no 1037 0.318764309138804 1364 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_413 propylparaben 100 µM 0.469202537590991 0.310109315832066 no 1038 0.319462435913826 1480 7175 A pharmaceutical preservative.
SGTC_22 0964-0034 14.468 µM 0.468444482030568 0.310394179124805 no 1039 0.319733382143879 1482 138402
SGTC_175 3793-3120 23.7 µM 0.467477738122937 0.310757628701747 no 1040 0.320079057917292 1510 5322297
SGTC_2810 7959871 45.46 µM 0.465111754518303 0.311647904426376 no 1041 0.320925714366989 1611 2974535
SGTC_343 4130-2827 29.8 µM 0.463585863205301 0.312222653990095 no 1042 0.321472242327073 1510 1118244
SGTC_878 0828-0289 13.7 µM 0.463373262626249 0.312302769473018 no 1043 0.321548420121026 1522 745350 YLR208W SEC13
SGTC_805 3852-0218 479 µM 0.462060450561562 0.312797680383983 no 1044 0.32201898540104 1493 6615355
SGTC_2173 5763948 167 µM 0.460202313985738 0.313498747679385 no 1045 0.322685505104152 1541 2867177
SGTC_2109 5483026 200 µM 0.46014066270214 0.313522020025833 no 1046 0.322707629405601 1568 759335
SGTC_1733 st037357 54.9 µM 0.459473281692891 0.313773992884982 no 1047 0.32294716723056 1443 1272339 YGL099W LSG1
SGTC_1911 st060208 74.3 µM 0.459031260662565 0.313940927855713 no 1048 0.32310585881483 1632 688783
SGTC_812 4251-0442 148 µM 0.458280374388463 0.314224597080425 no 1049 0.323375511040709 1541 5723007
SGTC_2363 9053361 176 µM 0.458105830794778 0.314290551750857 no 1050 0.32343820502741 1651 6469797 YMR079W SEC14
SGTC_1177 0983-0204 23.6 µM 0.456836625128705 0.314770323859099 no 1051 0.323894239304388 1638 766818
SGTC_2189 6047310 154.431 µM 0.456323171317962 0.314964503325433 no 1052 0.32407880194693 1506 711535
SGTC_759 3486-0358 89.3 µM 0.455934866083035 0.31511138771302 no 1053 0.324218408249864 1701 875103
SGTC_1495 4469-0029 237 µM 0.454037683155213 0.315829455972243 no 1054 0.324900852260619 1523 793680
SGTC_1052 3253-3998 198 µM 0.451022992533827 0.316971921995112 no 1055 0.325986488840053 1513 5450317
SGTC_631 k072-0230 41.5 µM 0.450813000249798 0.317051567197425 no 1056 0.326062165420013 1590 5773147
SGTC_1365 1672-3266 55.4 µM 0.450594895832508 0.317134298117694 no 1057 0.326140773018477 1623 6415873
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.450571361215086 0.317143225766946 no 1058 0.326149255654964 1631 6710655
SGTC_852 0418-0143 439 µM 0.450318698537818 0.317239077825456 no 1059 0.326240329112803 1575 5369229
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.449276135879904 0.317634722037983 no 1060 0.326616235306639 1645 1377
SGTC_2845 9003024 42.97 µM 0.448809767199609 0.31781177271079 no 1061 0.32678444614018 1637 2990173
SGTC_989 1501-0895 10.3 µM 0.44872370113602 0.317844451103168 no 1062 0.326815492478047 1626 2830112
SGTC_484 loperamide 105 µM 0.448696091438992 0.317854934519562 no 1063 0.326825452290425 1548 3955 An opioid-receptor agonist.
SGTC_955 1216-0110 33 µM 0.448255749814256 0.318022152192077 no 1064 0.32698431605052 1487 3619719
SGTC_1103 duloxetine 36.1 µM 0.448079783461555 0.31808898497026 no 1065 0.327047808887188 1653 60835 A selective serotonin reuptake inhibitor.
SGTC_2194 5927483 104.545 µM 0.446440156425633 0.318712006894226 no 1066 0.32763966568774 1574 760979
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.44494217742567 0.319281654046397 no 1067 0.328180770624947 1529 115019
SGTC_3037 9091026 49.47 µM 0.444716384405395 0.319367555021973 no 1068 0.328262363640179 1566 25236398 YIL048W NEO1
SGTC_2336 9001819 198.65 µM 0.444623196101795 0.319403010522215 no 1069 0.328296040739846 1652 2989602
SGTC_2435 5706476 10.6 µM 0.441748322286997 0.320497628223884 no 1070 0.329335668955475 1664 5725375
SGTC_1660 st012960 28.1 µM 0.440411110997918 0.321007309115754 no 1071 0.329819689496236 1556 24207266
SGTC_3340 9146634 11.102 µM 0.440128044047882 0.321115243986628 no 1072 0.329922185750679 1559 4907387
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.439196520197613 0.321470545451286 no 1073 0.33025957313223 1577 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_256 clotrimazole 625 nM 0.438482062967623 0.321743164195681 no 1074 0.330518435008509 1576 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2195 6536160 144.242 µM 0.437124933654733 0.322261274574609 no 1075 0.331010372865558 1501 3834386
SGTC_959 1222-0044 107 µM 0.436356228351689 0.322554896050612 no 1076 0.331289145900068 1667 6083612
SGTC_3100 9120536 49.47 µM 0.435006762768843 0.32307061753128 no 1077 0.331778759325003 1577 16421196
SGTC_2190 6049624 200 µM 0.434598345867757 0.323226768202346 no 1078 0.331926997948994 1607 2265554
SGTC_1192 1488-0095 21.4 µM 0.433035880680562 0.323824435299826 no 1079 0.332494351605159 1583 915875
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.432316889554926 0.324099613334463 no 1080 0.332755556735115 1709 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2518 prenyletin 46.28 µM 0.431954709666773 0.324238266137328 no 1081 0.332887165261203 1606 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1263 0774-1208 64.8 µM 0.4318965476974 0.324260534472164 no 1082 0.332908302012358 1706 906585
SGTC_2287 7945887 168.79 µM 0.431738879224948 0.324320903786698 no 1083 0.332965603280212 1657 1245853
SGTC_421 streptovitacin 30 mM 0.430083899915488 0.324954853354166 no 1084 0.333567305605608 1586 91467 include heat shock
SGTC_2424 5537928 59.2 µM 0.429896922121536 0.325026508220197 no 1085 0.333635312252561 1552 5382802
SGTC_1237 0330-0133 46.1 µM 0.429798527169261 0.325064218383553 no 1086 0.333671102177875 1563 X1237 YHR072W ERG7
SGTC_2643 anethole 100 µM 0.429096687100491 0.325333252675778 no 1087 0.333926431553866 1573 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.427422144394232 0.325975517804127 no 1088 0.334535940546906 1558 279621
SGTC_2596 sinensetin 100 µM 0.426406250972077 0.32636541219494 no 1089 0.334905923632034 1555 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2348 9022543 33.42 µM 0.424560119260521 0.327074433200126 no 1090 0.335578685306166 1625 3162678 YDL140C RPO21
SGTC_3261 9137475 49.47 µM 0.423799347991344 0.327366795103307 no 1091 0.335856076835188 1586 17027690
SGTC_855 0428-0020 25 µM 0.42362516977237 0.327433746129462 no 1092 0.335919598082204 1582 6812414
SGTC_3156 9099931 49.47 µM 0.423021414583121 0.327665861898901 no 1093 0.336139818501229 1629 18111053
SGTC_567 1080-0542 68.4 µM 0.422908040787899 0.327709456277846 no 1094 0.336181178002331 1658 5950415
SGTC_496 calpeptin 138 µM 0.422164643083284 0.327995364986779 no 1095 0.33645242345434 1546 73364 A calpain inhibitor.
SGTC_2725 haloperidol 53.21 µM 0.420628089190616 0.328586638807151 no 1096 0.337013339584142 1564 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2520 obtusaquinone 4.71 µM 0.419936897844928 0.328852752914176 no 1097 0.337265776015478 1682 5967872
SGTC_1696 st025591 34.7925 µM 0.419058937633258 0.329190899629414 no 1098 0.337586529691596 1598 2787147
SGTC_939 1165-0479 45.3 µM 0.418142935684236 0.329543847145573 no 1099 0.337921307334293 1624 1377347
SGTC_2328 6201408 200 µM 0.417419052268336 0.329822876350505 no 1100 0.338185960807229 1577 2890418
SGTC_426 0988-0037 14.6 µM 0.415066877210336 0.330730202674728 no 1101 0.339046473106768 1668 5383008
SGTC_1317 1273-0028 910 nM 0.41490188941828 0.330793882369082 no 1102 0.339106863312213 1596 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_49 0717-0965 32.132 µM 0.413104662853592 0.331487867762828 no 1103 0.339764966643346 1670 5889349 YGL099W LSG1
SGTC_2037 5169046 200 µM 0.411940240841674 0.331937809712019 no 1104 0.340191612438335 1644 5718022
SGTC_1412 3909-8563 178 µM 0.41040111022909 0.332532914062415 no 1105 0.340755865996272 1726 23767530
SGTC_184 1494-0393 24.714 µM 0.409931561065685 0.332714549237304 no 1106 0.340928076270592 1560 3090647
SGTC_1491 4138-0063 26.5 µM 0.409817879415064 0.332758530489107 no 1107 0.340969774756825 1679 23883227
SGTC_82 0054-0107 293.755 µM 0.40956378883743 0.332856841584027 no 1108 0.341062982330695 1729 3104697
SGTC_1114 scopoletin 1.73284 µM 0.409211089833071 0.332993324664423 no 1109 0.341192378326732 1722 5280460 A coumarin with genotoxic properties.
SGTC_565 1418-0001 44.5 µM 0.408743708172731 0.333174220301089 no 1110 0.341363877146796 1677 2862145
SGTC_1540 guanosine 70.6 µM 0.408065442236008 0.333436805730557 no 1111 0.341612815117151 1675 6802 Guanosine is a purine nucleoside
SGTC_465 cgp-37157 41 µM 0.406477324671691 0.334051952384339 no 1112 0.342195957313562 1698 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_110 0850-0284 111.64 µM 0.405751425818603 0.334333273078545 no 1113 0.342462626180471 1546 3906265
SGTC_1974 st069448 26.9 µM 0.404541570362163 0.334802356989043 no 1114 0.342907257635164 1725 6323587 YNR016C ACC1
SGTC_2475 5812728 15.03 µM 0.40399074817896 0.335016006678589 no 1115 0.343109761289607 1573 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_218 alverine citrate 93.75 µM 0.401817267817372 0.335859564041562 no 1116 0.343909256464488 1681 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1127 asiatic acid 681.4 nM 0.400863051519391 0.336230170088216 no 1117 0.344260477180462 1579 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_849 0386-0493 241 µM 0.398195332536366 0.337267123662747 no 1118 0.345243103104749 1605 726119
SGTC_807 1315-0151 48 µM 0.397907666617737 0.337379014661281 no 1119 0.345349124272271 1762 4011080
SGTC_1875 nocodazole 6 µM 0.396412495229614 0.337960810384783 no 1120 0.345900374832771 1702 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2333 9017922 200 µM 0.396394903066857 0.337967658091856 no 1121 0.345906862785464 1763 3163164
SGTC_1496 4469-0713 57.4 µM 0.39621735077999 0.338036772893936 no 1122 0.34597234622846 1723 746691
SGTC_1798 st045719 60.953 µM 0.395012512503425 0.338505917786633 no 1123 0.34641682684884 1687 3980186
SGTC_1018 4259-0013 28.1 µM 0.394453081671729 0.33872383655847 no 1124 0.346623280174324 1661 6801262
SGTC_3333 9141820 12.094 µM 0.393862486088573 0.338953953736062 no 1125 0.346841284033643 1612 1939433
SGTC_2936 9038235 15.59 µM 0.393838249200094 0.338963398579801 no 1126 0.346850231569764 1609 4749415
SGTC_3162 9099653 49.47 µM 0.392641522348333 0.33942987540782 no 1127 0.347292133552057 1674 25237511
SGTC_1058 3448-5425 97.3 µM 0.392398027033916 0.339524818555237 no 1128 0.347382071797912 1629 7279705
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.391726024885144 0.33978689695633 no 1129 0.347630329337364 1676 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_553 k007-0256 45.7 µM 0.391080560218122 0.340038698777093 no 1130 0.347868844684013 1666 6287000
SGTC_3134 9127454 49.47 µM 0.390926227608086 0.340098915952365 no 1131 0.347925883368779 1674 24262820
SGTC_2278 7948257 134.34 µM 0.390903392989449 0.340107825862586 no 1132 0.347934322944337 1795 1247028
SGTC_888 0916-0002 6.97 µM 0.390697935763089 0.340187997866485 no 1133 0.348010262427864 1725 2802138 YIL048W NEO1
SGTC_2125 5246583 200 µM 0.389188580248369 0.340777188755228 no 1134 0.348568325250453 1802 835267
SGTC_2752 diclazuril 33.15 µM 0.385980630671897 0.342030730915159 no 1135 0.349755506929269 1717 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_297 0986-0032 24 µM 0.383132611231586 0.343145087859176 no 1136 0.350810720413236 1639 2847425
SGTC_2141 5621638 7.665 µM 0.382925806983928 0.34322605834461 no 1137 0.350887387956963 1768 2856238
SGTC_189 3970-0742 2.116 µM 0.382283211151746 0.343477701106287 no 1138 0.351125653149504 1758 2891807
SGTC_2130 NSC 7 2.4545 µM 0.381824058925799 0.343657549227885 no 1139 0.35129593598134 1766 21448
SGTC_987 1497-1013 404 µM 0.381085846948915 0.343946778140393 no 1140 0.35156977448276 1675 1676435
SGTC_2137 5261020 140 µM 0.381046145191467 0.343962335742028 no 1141 0.351584503967874 1643 763655
SGTC_1757 st041620 31.8375 µM 0.380686211703561 0.344103391972941 no 1142 0.351718050663654 1629 5289815
SGTC_2111 5486399 200 µM 0.379779660923999 0.344458761030893 no 1143 0.352054490701763 1629 689674
SGTC_2885 9057732 51.95 µM 0.378532164245442 0.3449480058058 no 1144 0.35251765227959 1665 6471414
SGTC_3045 9092950 49.47 µM 0.377964654087691 0.34517065851093 no 1145 0.352728425795799 1780 44120432
SGTC_2421 5690543 90.72 µM 0.37652919596051 0.345734074580721 no 1146 0.353261757252875 1689 3397993
SGTC_2139 5578692 56.4705 µM 0.376429205892427 0.34577333334458 no 1147 0.353298918409313 1768 650991 YMR113W FOL3
SGTC_2222 6885208 172.143 µM 0.373815624817806 0.346800081964968 no 1148 0.354270746986631 1693 609514
SGTC_534 k292-0788 63.4 µM 0.373755243769831 0.346823816072973 no 1149 0.354293210199143 1839 4146317
SGTC_1557 sumaresinolic acid 42.3 µM 0.372823707125076 0.34719005329849 no 1150 0.354639828594017 1619 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1089 terbinafine 2.25 µM 0.369719699801029 0.348411434438952 no 1151 0.355795675981346 1755 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1203 3992-3522 103 µM 0.367299694546298 0.3493647632228 no 1152 0.356697740952871 1882 5322312
SGTC_34 0469-0683 81.75 µM 0.366571152757211 0.349651949076842 no 1153 0.356969464623277 1747 3690923
SGTC_41 0478-0632 82.643 µM 0.365263149583014 0.350167770247481 no 1154 0.357457491599302 1825 3750424
SGTC_1784 st039334 36.3 µM 0.364988903356097 0.350275956469515 no 1155 0.357559844770728 1778 3496984
SGTC_945 3381-0768 11.3 µM 0.364786315168242 0.350355882421196 no 1156 0.357635460571702 1735 1126236 YIL048W NEO1
SGTC_2188 6126565 140.678 µM 0.364209560431862 0.350583462426408 no 1157 0.357850764185819 1738 874518
SGTC_562 3772-2733 112 µM 0.364209138984707 0.350583628743659 no 1158 0.357850921529371 1762 2876874 YIL048W NEO1
SGTC_514 4466-0038 2.65 nM 0.36317712029552 0.350990983934713 no 1159 0.358236288918814 1725 5722064
SGTC_521 r062-0005 13.8 µM 0.362439461497298 0.351282255326055 no 1160 0.358511827567343 1654 2832033
SGTC_2912 7964298 10.93 µM 0.361692947274079 0.351577112317375 no 1161 0.358790749002695 1662 2975850
SGTC_3034 9090421 49.47 µM 0.360103045024396 0.352205386868149 no 1162 0.359385037869267 1792 17173761
SGTC_2057 5236571 38.335 µM 0.358513046133693 0.352834103278395 no 1163 0.359979703234995 1800 54684039 YBR257W POP4
SGTC_1927 st060202 13.8 µM 0.358377675034297 0.352887650235665 no 1164 0.360030348200065 1809 688887
SGTC_753 1322-0200 289 µM 0.358163394409323 0.35297241634806 no 1165 0.360110519778201 1716 5403907
SGTC_5 0352-0601 109.883 µM 0.35745628872434 0.353252188211327 no 1166 0.360375121999269 1702 762456
SGTC_2013 4024628 200 µM 0.35507782417588 0.354193827620125 no 1167 0.361265644672826 1724 5230760
SGTC_2862 9027634 71.43 µM 0.354931656357515 0.354251724943106 no 1168 0.361320396058948 1624 5012562
SGTC_3218 9131285 49.47 µM 0.35488968586046 0.354268350151434 no 1169 0.361336117848109 1813 17156417
SGTC_1297 1068-0111 14.1 µM 0.354444181857528 0.354444838773568 no 1170 0.361503014267148 1640 767057
SGTC_1990 st072050 59.8 µM 0.354401979371595 0.354461559119246 no 1171 0.361518825691427 1655 17233948
SGTC_2652 actinonin 100 µM 0.354209604539186 0.354537780307836 no 1172 0.361590903116489 1714 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3183 9108214 49.47 µM 0.353891129829521 0.354663976565589 no 1173 0.361710237404668 1733 4974831
SGTC_2863 9028737 58.44 µM 0.353457091295784 0.354835990909777 no 1174 0.361872895771004 1812 6460917
SGTC_544 k015-0020 52.4 µM 0.35249836133351 0.355216051211519 no 1175 0.362232273587328 1705 3008304
SGTC_2951 9072950 58.06 µM 0.351441834943136 0.355635046887554 no 1176 0.362628450859013 1754 16488155
SGTC_2199 6590217 200 µM 0.350553500391411 0.355987476361397 no 1177 0.362961673272731 1763 703109
SGTC_1940 st075990 51.1 µM 0.350169502486729 0.356139858191865 no 1178 0.363105746539411 1766 1084979
SGTC_1833 st055984 71 µM 0.350104625234056 0.356165605692038 no 1179 0.363130089934141 1709 676288
SGTC_1565 sinapyl alcohol 95.1 µM 0.349859448520388 0.356262913629593 no 1180 0.363222090707432 1642 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3291 9121177 71.43 µM 0.349640113358719 0.35634997327267 no 1181 0.36330440131504 1658 17015612
SGTC_875 0709-0210 25.7 µM 0.349137175754405 0.356549630120674 no 1182 0.363493164145239 1791 6251364
SGTC_968 1309-0633 340 µM 0.34905397000204 0.356582665044174 no 1183 0.363524396172763 1818 3761976
SGTC_881 0833-0569 170 µM 0.348667777150887 0.356736008084483 no 1184 0.363669369005708 1640 5418700
SGTC_2315 7733312 200 µM 0.34783927171456 0.357065055352138 no 1185 0.363980447284722 1665 726316
SGTC_1695 st026914 34.495 µM 0.347802953828198 0.3570794817131 no 1186 0.363994085585396 1688 3289191
SGTC_636 0kpi-0074 126 µM 0.347352274891982 0.357258519506493 no 1187 0.364163341448564 1702 616434
SGTC_785 1270-0111 65.3 µM 0.345138370611688 0.358138476175653 no 1188 0.364995174077793 1697 6741994
SGTC_1180 1193-0155 285 µM 0.344411014031642 0.358427742133983 no 1189 0.365268603488365 1677 2921347
SGTC_1266 0828-0227 32.9 µM 0.344309256231364 0.358468217168795 no 1190 0.365306861959283 1775 3913820
SGTC_2703 st077852 53.4 µM 0.344169500856517 0.358523808655041 no 1191 0.365359408783553 1725 6281836
SGTC_435 c-PAF 6.7 µM 0.343788945894045 0.358675199894352 no 1192 0.365502507000073 1781 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_12 0849-0099 9.267 µM 0.342996741626882 0.358990423443093 no 1193 0.365800455720561 1795 6071388
SGTC_2566 crystal violet carbinol 226 nM 0.342854194299179 0.359047154210914 no 1194 0.365854076496113 1608 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3042 9091578 49.47 µM 0.342075326539559 0.359357181678317 no 1195 0.366147102590178 1735 25236497
SGTC_898 1000-0849 28.3 µM 0.342043847577275 0.359369713793713 no 1196 0.366158947266901 1791 6751807
SGTC_2244 6635614 200 µM 0.341460525741679 0.359601967888514 no 1197 0.366378458464071 1710 836499
SGTC_3021 9087658 49.47 µM 0.33897732348941 0.360591253488647 no 1198 0.367313406562703 1786 25237042
SGTC_1600 coumarin 106 71.1 µM 0.336849078389973 0.361439870791829 no 1199 0.368115336830394 1766 100336 A hepatotoxic, DNA x-linker.
SGTC_771 0250-0039 27.3 µM 0.336081423398714 0.361746133466933 no 1200 0.368404733241965 1734 3005115
SGTC_322 k048-0136 19.3 µM 0.335855464879221 0.361836298477349 no 1201 0.368489931033073 1741 6823282
SGTC_1032 k061-1018 98.7 µM 0.335780248371121 0.361866314082801 no 1202 0.368518292895762 1875 4005393
SGTC_1876 myriocin 605 nM 0.334344745033145 0.362439323095268 no 1203 0.369059714768715 1836 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2374 9071832 200 µM 0.332036081346987 0.363361517196532 no 1204 0.369931007048766 1739 17381698
SGTC_265 mycophenolic acid 32.932 µM 0.331319469164996 0.363647928860689 no 1205 0.37020159337384 1833 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1647 st011722 22.4 µM 0.328155874090716 0.364913246351643 no 1206 0.371396904719489 1763 2854783
SGTC_1752 st044819 83.042 µM 0.328011308479179 0.364971102374369 no 1207 0.371451556156449 1682 441209 YML126C ERG13
SGTC_2245 6637752 200 µM 0.325557615212115 0.365953553044373 no 1208 0.372379542322021 1870 681890
SGTC_113 0099-0221 2.5 µM 0.323436854030882 0.366803407820348 no 1209 0.373182211320199 1838 89219
SGTC_635 k038-0028 24.7 µM 0.320053264246378 0.368160668415567 no 1210 0.374463976673413 1790 4035102
SGTC_3329 9141233 27.5565 µM 0.320005675570774 0.368179769464037 no 1211 0.374482014064057 1839 4909101 YNL103W MET4
SGTC_2855 9016525 58.44 µM 0.319649542267273 0.368322723886123 no 1212 0.374617006901511 1724 43811474
SGTC_1364 1653-0028 37.6 µM 0.318977888247804 0.368592380151923 no 1213 0.374871640127802 1747 5718652
SGTC_3082 9117008 49.47 µM 0.317878472418781 0.36903391424556 no 1214 0.375288561405601 1741 41448529
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.317702850881015 0.369104461272393 no 1215 0.37535517424478 1809 5393153
SGTC_2293 7624732 200 µM 0.315649239504177 0.369929721923351 no 1216 0.37613437959561 1679 894453
SGTC_2697 mebhydrolin 72.4 µM 0.315612367576375 0.36994454469947 no 1217 0.376148374601755 1880 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2861 9024595 19.48 µM 0.315554522207691 0.369967799336675 no 1218 0.376170330556827 1819 16482810
SGTC_3215 9129942 49.47 µM 0.315246350100933 0.370091696791979 no 1219 0.376287308004438 1907 17682944
SGTC_408 cantharidin 100 µM 0.314271059060569 0.37048389141279 no 1220 0.376657588509214 1786 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_918 glabranin 770.725 nM 0.312405586380283 0.37123443033292 no 1221 0.377366152682735 1793 124049 Also referred to as licorice root.
SGTC_651 3253-0966 34.4 µM 0.310127649439481 0.372151580979687 no 1222 0.378231943457351 1754 781462
SGTC_2741 miltefosine 3.04 µM 0.309116558724488 0.372558902606623 no 1223 0.378616431791278 1791 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2797 7859098 81.82 µM 0.307725976051674 0.373119336778474 no 1224 0.37914542610472 1745 972681
SGTC_971 1315-0384 26.7 µM 0.307520446483998 0.373202192342541 no 1225 0.379223631242849 1710 6769120
SGTC_1117 retinoic acid 1.10837 µM 0.306773439993488 0.373503383991298 no 1226 0.379507912956856 1911 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.306030324317936 0.373803083559872 no 1227 0.379790778623563 1725 5282362
SGTC_2523 spermine 47.74 µM 0.305367224436578 0.37407057709045 no 1228 0.380043240741456 1907 1103 A DNA binding polyamine.
SGTC_592 k241-0073 46.5 µM 0.304271827433778 0.374512591444493 no 1229 0.380460403346492 1864 4230158
SGTC_2533 agelasine 13.65 µM 0.303245310441494 0.374926961095938 no 1230 0.380851460445571 1941 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_612 0302-0167 22.4 µM 0.30076526252643 0.375928666370048 no 1231 0.381796749536392 1871 235821
SGTC_1613 st002381 52.1 µM 0.300550659606832 0.376015385119038 no 1232 0.381878580303198 1872 551167
SGTC_3075 9116269 49.47 µM 0.298838967924102 0.376707285251217 no 1233 0.382531458323957 1795 17015205 YNL244C SUI1
SGTC_357 1325-0123 420 µM 0.298403807050438 0.376883249267802 no 1234 0.382697491874612 1915 1098503
SGTC_1726 st035556 14.5795 µM 0.29821199111048 0.376960821127949 no 1235 0.382770685177797 1879 5919439
SGTC_779 1360-0071 233 µM 0.297553170628349 0.377227291069039 no 1236 0.383022110375888 1932 7566
SGTC_2118 5526350 200 µM 0.296349763671416 0.377714178138947 no 1237 0.383481492909112 1823 743594
SGTC_2087 5276107 200 µM 0.29586242809332 0.377911404838772 no 1238 0.383667572595909 1756 144405
SGTC_743 1275-0778 158 µM 0.293698615095606 0.37878749253072 no 1239 0.384494106329841 1892 2849257 YMR203W TOM40
SGTC_3139 9095020 49.47 µM 0.293447357157137 0.378889262671555 no 1240 0.384590116005074 1775 25236292
SGTC_2617 dihydrotanshinone i 20.83 µM 0.293143045665543 0.379012532998963 no 1241 0.384706407769742 1751 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1407 3909-7909 12.3 µM 0.292881245637016 0.379118592654725 no 1242 0.38480646220274 1770 4411780
SGTC_1392 3455-1037 33.9 µM 0.291704510086938 0.379595420565548 no 1243 0.385256280290446 1877 981132
SGTC_372 0155-0182 15.9 µM 0.290897972521572 0.379922345482903 no 1244 0.385564675993986 1851 771486
SGTC_145 3737-0113 38.366 µM 0.290227942477919 0.380194003219247 no 1245 0.385820930364555 1910 6849351
SGTC_3005 9076496 71.4286 µM 0.290007778088715 0.380283279826761 no 1246 0.385905143572213 1888 21368410
SGTC_211 3455-0679 143.504 µM 0.289948296158598 0.380307400829828 no 1247 0.385927896422083 1795 748649
SGTC_2473 5854593 8.94 µM 0.28731144570789 0.381377157977523 no 1248 0.386936929772619 1779 2872951
SGTC_2638 epoxomicin 18 µM 0.286705902030487 0.381622952389521 no 1249 0.387168759033945 1902 9915668 A protesome inhibitor.
SGTC_823 0417-1665 178 µM 0.285265827567984 0.382207680286142 no 1250 0.387720245628595 1823 3429856
SGTC_2220 6782180 200 µM 0.285043229776574 0.382298087917011 no 1251 0.387805511257471 1901 833803
SGTC_704 1310-0270 142 µM 0.28451353430624 0.382513248427065 no 1252 0.38800843177229 1750 5718033
SGTC_765 1319-0117 244 µM 0.284272261341076 0.382611264718131 no 1253 0.388100870935441 1743 3487746 YGL099W LSG1
SGTC_1692 fluoroquinolonic acid 71 µM 0.282098109262268 0.383494844819954 no 1254 0.388934141485762 1857 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2627 acetyl isogambogic acid 100 µM 0.281824359330691 0.383606140449936 no 1255 0.389039095828685 1728 6857789 A caspase activator and apoptosis inducer.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.281533158962303 0.383724541261738 no 1256 0.389150749469089 1927 688798
SGTC_940 3232-1287 54.8 µM 0.28136249259531 0.383793938515971 no 1257 0.389216191557609 1957 1585493 YIL048W NEO1
SGTC_2979 9012552 45.46 µM 0.280493842749596 0.384147211193746 no 1258 0.389549324362801 1947 17100905
SGTC_127 0180-0333 59.125 µM 0.279692465174132 0.384473210184823 no 1259 0.389856729816031 1906 771601
SGTC_3231 9132313 49.47 µM 0.279658734138371 0.384486933704822 no 1260 0.389869670428277 1838 4905967
SGTC_2651 TUB2.036 5 µM 0.279347537529864 0.384613551315738 no 1261 0.389989063999331 1915 15992207 YFL037W TUB2
SGTC_2191 5911152 200 µM 0.27912439277282 0.384704350552431 no 1262 0.39007468202133 1820 2875902
SGTC_1234 0326-0494 15.5 µM 0.278323895550698 0.38503013074437 no 1263 0.390381867254236 1903 1547813
SGTC_1453 4237-0541 195 µM 0.277276156869246 0.385456653981381 no 1264 0.390784033070296 1943 739892
SGTC_485 niflumic acid 177 µM 0.276847449690063 0.385631216078377 no 1265 0.390948622481907 1868 4488 A COX2 inhibitor.
SGTC_1159 4092-0538 61.2 µM 0.276726937599447 0.385680290675911 no 1266 0.390994893045155 1838 717301
SGTC_2645 abamectin 100 µM 0.27543824811388 0.386205181478839 no 1267 0.391489781147996 1901 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_149 3970-0822 46.1 µM 0.273070629085366 0.387170069000925 no 1268 0.392399461796385 1805 3114250 YBL034C STU1
SGTC_1564 D-Arginine 115 µM 0.272610754134931 0.387357565209491 no 1269 0.392576222178633 1732 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_789 1309-1135 70.6 µM 0.272432210871778 0.387430366397564 no 1270 0.392644854146413 1733 3092424
SGTC_942 3253-1115 227 µM 0.271404332601553 0.38784956167893 no 1271 0.393040035063349 1918 46497897
SGTC_3267 9137951 49.47 µM 0.271132970693223 0.387960251900715 no 1272 0.393144382024177 1833 16643986
SGTC_2664 lyso-paf C-16 73.48 µM 0.269897323248181 0.388464395214934 no 1273 0.393619623261971 1851 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2128 5255449 168.493 µM 0.269736624072412 0.388529974198225 no 1274 0.393681441288287 1811 736008
SGTC_224 benfluorex 43.875 µM 0.269094371689522 0.388792099710153 no 1275 0.393928530744463 1927 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1895 st058434 18.3 µM 0.267762250221043 0.389335946079354 no 1276 0.394441164958931 1965 5393175
SGTC_723 4182-0001 115 µM 0.267078305682046 0.389615254743251 no 1277 0.394704435315828 1793 744821 YLR208W SEC13
SGTC_48 0382-0018 55 µM 0.265937583654565 0.39008122859512 no 1278 0.39514363970007 1952 762596
SGTC_229 benomyl 22.8748 µM 0.265248498882005 0.390362789610531 no 1279 0.39540901788383 1825 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1907 st060210 83.7 µM 0.265194435271289 0.390384882513602 no 1280 0.395429840747188 1931 688793
SGTC_2352 9027995 87.8 µM 0.26386615202043 0.390927791774156 no 1281 0.395941529153778 1876 2997347
SGTC_2274 7947094 46.08 µM 0.26099062575168 0.392103832909351 no 1282 0.397049868182193 1928 2971028
SGTC_1283 0922-0125 16.4 µM 0.260843949919398 0.39216384734848 no 1283 0.397106425097379 1904 3360884
SGTC_993 3909-8757 62.7 µM 0.25959121950916 0.392676523646911 no 1284 0.397589555009387 1845 4288324 YLR208W SEC13
SGTC_1644 st010134 20.9 µM 0.257933272616005 0.393355319888909 no 1285 0.398229202810715 1970 3818134
SGTC_3125 9127534 49.47 µM 0.257426708610783 0.393562781984479 no 1286 0.39842469348011 1962 1639235
SGTC_2834 9001755 58.44 µM 0.257380578974368 0.393581675770599 no 1287 0.398442496867901 1821 2989575
SGTC_204 PMA1.184 62.41 µM 0.257339295046915 0.393598585062698 no 1288 0.39845843026984 1870 2252213 YGL008C PMA1
SGTC_206 4546-0025 72.014 µM 0.257161608849032 0.393671365017189 no 1289 0.398527009630833 1858 6620745 YIL048W NEO1
SGTC_3074 9116018 49.47 µM 0.257092970040669 0.39369948034727 no 1290 0.398553502148461 1860 17027303
SGTC_2659 sanguinarine 24.21 µM 0.255337239749315 0.394418837831352 no 1291 0.399231319884957 1860 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2925 9010536 32.5 µM 0.254332870622303 0.394830509900626 no 1292 0.399619203705769 1902 2994177
SGTC_2826 7992541 19.48 µM 0.254030501374155 0.394954468407722 no 1293 0.39973599706875 1922 2985066
SGTC_2389 9091542 195.52 µM 0.253900726022508 0.395007674033873 no 1294 0.399786126941408 1837 3626624 YOL127W RPL25
SGTC_51 1013-0126 23.419 µM 0.252897183980582 0.395419174768126 no 1295 0.400173832807471 2017 1627850
SGTC_1418 3966-3099 2.4 µM 0.251165271932998 0.396129616497516 no 1296 0.400843166538837 1932 740335
SGTC_1329 1447-1697 50.6 µM 0.25090202907425 0.396237630724768 no 1297 0.400944927804845 1881 2840515
SGTC_2387 9077560 195.08 µM 0.250075136012455 0.396576974571118 no 1298 0.401264621889525 1831 5303272
SGTC_1343 1487-0095 224 µM 0.250063744921074 0.396581649842716 no 1299 0.401269026384904 1988 4560101 YGL055W OLE1
SGTC_661 1304-0007 33.6 µM 0.249130343399083 0.396964798424551 no 1300 0.401629979312236 1849 3117130
SGTC_3319 9138450 16.7555 µM 0.2490892136453 0.396981683917946 no 1301 0.40164588641019 1858 2029690
SGTC_1558 st069300 45.6 µM 0.248194059827654 0.39734922999138 no 1302 0.401992131082486 1987 24208000
SGTC_892 0929-0076 29 µM 0.247793214151386 0.397513844969542 no 1303 0.402147202775342 1837 5751038
SGTC_1217 1183-1422 255 µM 0.246569379020187 0.398016549202852 no 1304 0.402620752474688 1948 2849664
SGTC_1681 tripelennamine 100 µM 0.244614794049052 0.398819768167427 no 1305 0.403377354008645 1889 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1905 st060207 84.5 µM 0.243290234435971 0.399364327839287 no 1306 0.403890284478238 1856 1948547
SGTC_2384 9036245 200 µM 0.23936816682449 0.400977932998399 no 1307 0.405410055892659 1973 6462766
SGTC_2739 tacrine 100.86 µM 0.237914556143926 0.401576404016232 no 1308 0.40597368273123 1900 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_972 1319-0219 195 µM 0.237488702305769 0.401751777553799 no 1309 0.406138841395232 1859 23903702
SGTC_2286 7945697 125 µM 0.236641816902276 0.402100597508577 no 1310 0.406467338117006 1818 1245733
SGTC_2445 5742597 35.57 µM 0.236495422804974 0.402160903051564 no 1311 0.406524129317437 1853 1774255
SGTC_576 1073-0113 22.7 µM 0.236242520706034 0.402265088956968 no 1312 0.406622243190291 2016 5439563
SGTC_1087 pterostilbene 9.05 µM 0.236080426801576 0.402331869042406 no 1313 0.406685130926343 1986 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1308 1187-1617 41.4 µM 0.235681404177026 0.402496272097337 no 1314 0.406839950388193 1866 2882570
SGTC_101 0490-5701 117.494 µM 0.232862235513434 0.403658299855118 no 1315 0.407934192022993 1998 4661669
SGTC_2262 9014885 67.46 µM 0.231957254437079 0.404031503197779 no 1316 0.408285607185302 2007 6457424
SGTC_1415 3966-0071 78.1 µM 0.231511451471896 0.404215379135587 no 1317 0.408458745040164 1922 2893185
SGTC_569 4130-2812 160 µM 0.23078257597069 0.404516056769849 no 1318 0.408741859116227 2030 743552
SGTC_2532 xanthone 78.9 µM 0.230373914246827 0.404684663663744 no 1319 0.408900614734755 1973 7020 An insecticide.
SGTC_1366 1683-0113 21.9 µM 0.229777905116627 0.404930598642243 no 1320 0.409132177272096 1863 708623
SGTC_840 0245-0196 390 µM 0.22957390124368 0.405014786669377 no 1321 0.409211444512498 1981 3827528
SGTC_3150 9097574 49.47 µM 0.228901689599661 0.40529222509985 no 1322 0.409472663660602 2013 17217476
SGTC_1067 clotrimazole 1.36 µM 0.228514923782232 0.405451874532781 no 1323 0.409622977760351 1887 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1073 triclabendazole 3.09 µM 0.228041705234319 0.405647231373669 no 1324 0.409806909239371 1906 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_547 1120-0019 610 nM 0.227292314903275 0.40595664712333 no 1325 0.410098224279846 1880 3676939
SGTC_2676 harmalol 100 µM 0.226554791328901 0.406261220577182 no 1326 0.410384974736572 1986 5459187 A monoamine oxidase inhibitor
SGTC_1718 roemerine 11.9335 µM 0.226516854728955 0.406276888705326 no 1327 0.410399725850066 1974 235224 An aporphine alkaloid with mutagenic activity.
SGTC_130 0136-0219 337.655 µM 0.224562162841776 0.407084395089273 no 1328 0.411159951379272 2036 234244
SGTC_2732 terfenadine 20 µM 0.223622184502455 0.407472852181825 no 1329 0.41152565002152 1967 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3295 9122362 53.5725 µM 0.222262532240723 0.408034905385292 no 1330 0.412054758779383 1868 4730473
SGTC_93 0109-0045 59.227 µM 0.222196922857753 0.408062031796006 no 1331 0.412080294726735 2033 88733
SGTC_73 0327-0325 16.231 µM 0.221685389747413 0.408273541909706 no 1332 0.412279402217431 2055 53298
SGTC_1699 st031318 29.054 µM 0.22102055582829 0.408548479196272 no 1333 0.412538213755291 1978 5340658
SGTC_2921 7974240 10.71 µM 0.220851349392071 0.408618460493125 no 1334 0.412604089782738 1952 2979074 YDR527W RBA50
SGTC_3214 9129694 49.47 µM 0.220199013788699 0.408888284169906 no 1335 0.412858082331414 2017 17158655
SGTC_2263 7948595 193.29 µM 0.219407950319023 0.40921554737681 no 1336 0.413166138724596 1872 2971371
SGTC_68 0986-0284 82.829 µM 0.218849283049757 0.409446706344872 no 1337 0.413383727482608 1732 423278 YIL048W NEO1
SGTC_3170 9103054 49.47 µM 0.218273097094377 0.409685146977611 no 1338 0.41360816725674 1902 16432970
SGTC_274 sirtinol 40.1 µM 0.217889716055383 0.409843818470092 no 1339 0.413757520025841 1845 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_105 0111-0055 734.78 µM 0.216462214354679 0.41043475413231 no 1340 0.414313737756154 1942 5179370
SGTC_1426 4048-4480 71.7 µM 0.215489740471752 0.410837440796311 no 1341 0.414692755051178 1999 14224343
SGTC_3161 9100388 49.47 µM 0.214689551499194 0.41116885740386 no 1342 0.415004684669143 1964 25236368
SGTC_522 1273-0010 11.6 µM 0.214516960251233 0.411240348347172 no 1343 0.415071971211871 1938 5705015
SGTC_2868 9035608 32.47 µM 0.213347163377372 0.411724980520083 no 1344 0.415528094594787 1902 6462614
SGTC_1579 chlormadinone acetate 49.4 µM 0.212180832932697 0.412208310696068 no 1345 0.415982979704173 2044 45114258 A steroidal progestin.
SGTC_1452 4194-0072 190 µM 0.211757085769552 0.412383945575723 no 1346 0.416148274910376 2048 1343545
SGTC_3067 9117431 49.47 µM 0.211694556319153 0.4124098642918 no 1347 0.416172667642084 1891 17150885
SGTC_523 1934-0222 13.7 µM 0.211368503132244 0.41254502087415 no 1348 0.416299866183835 1860 1361595
SGTC_2819 7996655 46.38 µM 0.211208004930417 0.412611554898368 no 1349 0.416362482309384 2007 6456960
SGTC_1607 st000305 50.6 µM 0.211173193243918 0.41262598630484 no 1350 0.416376063881488 2026 5457690
SGTC_3026 9090633 49.47 µM 0.210006172020312 0.413109850619941 no 1351 0.416831427938324 1909 25236842
SGTC_364 0083-0097 67.7 µM 0.208645441528575 0.413674196339228 no 1352 0.417362516987003 1913 5207356
SGTC_2716 st080858 38.6235 µM 0.207792308661474 0.414028113421982 no 1353 0.417695569171415 2025 5296050
SGTC_1929 genistein trimethyl ether 50.5 µM 0.207429098402759 0.414178810242699 no 1354 0.41783737975534 2087 136420
SGTC_634 1611-4317 11.2 µM 0.206409435490829 0.41460193833062 no 1355 0.41823555053464 2088 2843522
SGTC_2903 5923464 63.88 µM 0.205976584834447 0.414781587755348 no 1356 0.41840460085846 2068 2876576
SGTC_450 aminopyrene 156 nM 0.20498887181377 0.415191592770822 no 1357 0.418790409709672 2025 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3289 9119912 71.43 µM 0.202814187136109 0.416094641133149 no 1358 0.419640134327783 1958 17014829
SGTC_3332 9141069 11.198 µM 0.202661493256201 0.416158064713193 no 1359 0.419699811243975 1876 17332883
SGTC_2870 9038528 12.99 µM 0.202652882714269 0.416161641289596 no 1360 0.419703176532685 1951 6463316
SGTC_2889 9059656 51.95 µM 0.202103305019753 0.416389934722916 no 1361 0.419917982074768 1994 3949838
SGTC_1922 5578187 25 µM 0.201002874554955 0.41684713596683 no 1362 0.420348163185713 2050 1350412
SGTC_597 k018-0003 82.8 µM 0.197903577082521 0.418135418931482 no 1363 0.421560252712434 2024 6786234
SGTC_1336 1486-0901 104 µM 0.19753453377646 0.418288877744526 no 1364 0.421704629873077 1972 5006114
SGTC_2276 7947513 42.08 µM 0.197228727106135 0.418416050372509 no 1365 0.421824275565831 1794 2105100
SGTC_1679 SEC14.276 6.7 µM 0.19648337891997 0.41872604624203 no 1366 0.42211592040709 2080 1005053 YMR079W SEC14
SGTC_1682 st012968 530 nM 0.19583456549319 0.41899593368546 no 1367 0.422369827259285 1882 24207270
SGTC_2926 9010726 65.15 µM 0.192354790184111 0.42044406612367 no 1368 0.423732151626746 1897 2994293
SGTC_10 0279-0212 42.575 µM 0.191104257267639 0.420964748209361 no 1369 0.424221956146151 2023 39851 YBR002C RER2
SGTC_1510 1123-0200 71.5 µM 0.191066184481604 0.420980602678726 no 1370 0.424236870206798 2054 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1559 coumarin 343 70.1 µM 0.189993666725848 0.421427278710863 no 1371 0.424657046681327 2049 108770 A hepatotoxic, DNA x-linker.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.189659505414316 0.421566468984223 no 1372 0.424787977389887 2001 676296 Flavone; oxidizing agent.
SGTC_2502 avocadyne acetate 18.59 µM 0.189648348743208 0.421571116310458 no 1373 0.424792348927419 2080 3952079
SGTC_1512 0259-0544 12.2 µM 0.187842071340712 0.422323667184295 no 1374 0.425500227294634 1977 18476
SGTC_163 TUB2.036 7.546 µM 0.18693125477724 0.422703249208023 no 1375 0.42585726667054 2100 15992207 YJR013W GPI14
SGTC_347 4534-1311 26.2 µM 0.186734166305515 0.422785395119118 no 1376 0.42593453320702 1997 2862016
SGTC_902 1120-0002 2.07 µM 0.186036543088904 0.423076189433281 no 1377 0.426208052141498 2031 3280475
SGTC_2247 cerulenin 830 nM 0.185618774418283 0.423250350436719 no 1378 0.426371864785502 2063 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_566 0958-0068 16.5 µM 0.185144832778381 0.423447947199674 no 1379 0.426557718975724 2049 6815365
SGTC_1609 st001574 46.4 µM 0.184374499458885 0.423769157275547 no 1380 0.4268598366766 1934 3960012
SGTC_114 0364-0001 490.298 µM 0.184290260855912 0.423804285780684 no 1381 0.426892876894284 1923 4003655
SGTC_3293 9120939 62.045 µM 0.18422184225065 0.423832817603161 no 1382 0.42691971254126 2018 934087
SGTC_1765 st044815 90.4 µM 0.183854417657899 0.423986047272972 no 1383 0.427063832291449 1885 645695
SGTC_3229 9132204 49.47 µM 0.183640714861345 0.424075174545341 no 1384 0.427147660211724 2007 17682924
SGTC_2705 st078069 42.8 µM 0.183528162305079 0.424122117478264 no 1385 0.427191811853938 1971 1530061
SGTC_2907 7721985 69.9 µM 0.183327957899182 0.424205620525375 no 1386 0.427270349447786 1926 3267881
SGTC_3095 9117207 49.47 µM 0.181468153048233 0.424981486729141 no 1387 0.428000064154117 2088 17015229
SGTC_170 4197-0004 226 µM 0.180451345739258 0.425405797574118 no 1388 0.428399123889226 2012 218692
SGTC_1973 st070275 50.2 µM 0.1799522272176 0.425614109985749 no 1389 0.428595036500847 2112 17118334
SGTC_1539 benzyladenosine 56 µM 0.179466569096438 0.425816824489 no 1390 0.428785682565691 1993 92208 A nucleotide analog.
SGTC_1460 k062-0059 9.15 µM 0.17864417844586 0.426160136392169 no 1391 0.429108551528256 2016 1373085
SGTC_2621 lithochol-11-enic acid 100 µM 0.178628735328639 0.426166583750121 no 1392 0.42911461492033 2111 6708711
SGTC_3275 9138069 49.47 µM 0.178586880945874 0.426184057665257 no 1393 0.429131048184919 2000 17617007
SGTC_740 k014-0057 261 µM 0.178229390458334 0.42633331337145 no 1394 0.429271414491855 2082 4012779
SGTC_1751 st044839 27.194 µM 0.177069576916301 0.426817619186411 no 1395 0.429726869198204 2115 5291326
SGTC_1821 st053465 65.6 µM 0.176634719203488 0.426999232131175 no 1396 0.429897660439338 1981 675086
SGTC_2059 5238311 157 µM 0.176340450919951 0.4271221384214 no 1397 0.430013242343979 1963 703021
SGTC_3073 9114972 49.47 µM 0.175680853892983 0.427397656328769 no 1398 0.430272338864323 2119 41905075
SGTC_909 3448-9333 149 µM 0.175003770820878 0.427680515102967 no 1399 0.430538335312673 1956 3344074
SGTC_596 1155-0152 116 µM 0.174577706590238 0.427858527107468 no 1400 0.430705733556873 1971 280313
SGTC_2216 7189485 200 µM 0.173989060872599 0.428104490712962 no 1401 0.430937029633884 2093 731273
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.172491721743165 0.428730274456656 no 1402 0.431525484457075 2133 5024745
SGTC_1167 k781-0610 148 µM 0.171760203562579 0.429036063504132 no 1403 0.431813026718485 1998 4525169
SGTC_2168 5727979 200 µM 0.170094401385768 0.429732560373852 no 1404 0.432467948202982 2095 695210
SGTC_2486 5283202 22.39 µM 0.16986985093767 0.429826465062765 no 1405 0.432556245977021 1936 1377751
SGTC_112 phenothiazine 287.218 µM 0.169526742870959 0.429969956994683 no 1406 0.432691169506128 2118 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2047 4141938 200 µM 0.168649833390655 0.430336733105087 no 1407 0.433036040281582 1998 3807862
SGTC_846 0335-0850 148 µM 0.168476126235744 0.43040939499322 no 1408 0.433104361855735 2099 6819598
SGTC_463 ikarugamyin 104 µM 0.168197777247755 0.430525833583974 no 1409 0.433213844767252 2116 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1315 1237-0019 3.69 µM 0.167630237723255 0.430763264692295 no 1410 0.433437090764564 2108 825140
SGTC_2488 5268135 45.7 µM 0.167205110302455 0.430941133859882 no 1411 0.4336043317934 2052 1270356 YLR208W SEC13
SGTC_1923 st058458 19.1 µM 0.167137284596213 0.430969512770707 no 1412 0.433631014872774 2132 3534982
SGTC_2636 apigenin dimethyl ether 100 µM 0.166855933349048 0.431087236572168 no 1413 0.433741703534224 2033 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_285 1486-1325 46 µM 0.166798799327837 0.431111143502603 no 1414 0.433764181724968 2093 22310230
SGTC_1629 st005085 44.9 µM 0.164821927805597 0.431938492548931 no 1415 0.434542072097527 1967 24207091
SGTC_924 2046-0044 21.3 µM 0.164068562314284 0.432253865575745 no 1416 0.434838585024114 2148 3623589
SGTC_1645 Cervolide 78 µM 0.163078952879292 0.432668200350421 no 1417 0.435228135557174 2022 23173 A fragrance.
SGTC_2193 5925765 200 µM 0.161325926634667 0.433402347885935 no 1418 0.435918352102705 2089 877370
SGTC_1040 k898-0338 155 µM 0.161294468610722 0.433415524257004 no 1419 0.435930739815291 2169 20969351
SGTC_310 1273-0058 1.06 µM 0.160931419721445 0.433567594687499 no 1420 0.436073707736439 2091 2734232
SGTC_2204 7233102 200 µM 0.160489991023272 0.433752509346372 no 1421 0.436247552719719 2069 2172480
SGTC_1332 1480-0653 17.5 µM 0.160125399995534 0.43390524761004 no 1422 0.436391146513403 2156 5749438
SGTC_1075 aripiprazole 15.2 µM 0.16007360370897 0.433926947450054 no 1423 0.436411547107038 2010 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2361 9034121 116 µM 0.159528457873143 0.434155346107532 no 1424 0.436626269632969 2002 6496917
SGTC_3185 9108267 49.47 µM 0.158790587246869 0.434464525283919 no 1425 0.43691693250318 1985 4910486
SGTC_1202 1988-0068 29.6 µM 0.158660785275581 0.434518918464066 no 1426 0.436968067776312 1948 2850480
SGTC_1255 0566-0045 221 µM 0.158554285076629 0.434563548022601 no 1427 0.437010024141095 2040 2788469
SGTC_2449 5812982 45.77 µM 0.158088386384034 0.434758795509804 no 1428 0.437193575928511 2111 776185
SGTC_2684 capsaicin 100 µM 0.157839377268198 0.434863156063357 no 1429 0.437291684493928 2053 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3022 9087993 49.47 µM 0.157696852148946 0.434922890860266 no 1430 0.437347840539104 2116 17173644
SGTC_628 1636-0253 16 µM 0.157558399054801 0.434980920421833 no 1431 0.437402393382182 2109 4456143
SGTC_3135 9127742 49.47 µM 0.156207841430708 0.435547050144467 no 1432 0.437934598022159 1972 3643468
SGTC_3190 9110366 49.47 µM 0.155812760856616 0.435712685919569 no 1433 0.438090305885787 2135 17123768
SGTC_1819 st053448 58.6 µM 0.15472553658834 0.43616855799771 no 1434 0.43851884857115 2044 2857616
SGTC_747 3448-8087 38.7 µM 0.153538016982921 0.436666580700152 no 1435 0.438987006246691 2012 5168703
SGTC_280 3448-3607 3.04 µM 0.153161350703599 0.43682456824725 no 1436 0.439135517835296 2137 626179
SGTC_1962 st076595 64.5 µM 0.15155329122177 0.43749915995793 no 1437 0.439769637971121 2061 279619
SGTC_1706 st031321 9.9705 µM 0.150955260834379 0.437750084168899 no 1438 0.440005504028852 2126 6103185
SGTC_452 diindolylmethane 8 µM 0.150473403014631 0.437952282402083 no 1439 0.440195566562634 2080 3071 Inhibits expression of several cancer promoting factors.
SGTC_1031 k035-0009 16 µM 0.149965322164637 0.438165501947553 no 1440 0.440395987354625 2133 5180959
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.148243722508704 0.438888115931935 no 1441 0.441075213709367 2064 6708784 An antioxidant flavonoid
SGTC_2372 9071633 200 µM 0.148203028664532 0.438905198997915 no 1442 0.441091270843007 2174 21321366
SGTC_510 ag-490 170 µM 0.148192402438633 0.438909659851502 no 1443 0.441095463796063 2175 5328779
SGTC_1001 4048-4355 44.4 µM 0.148115785845199 0.438941823467163 no 1444 0.441125695776728 2064 21824233
SGTC_820 1582-0060 59.9 µM 0.148001654349095 0.438989736571706 no 1445 0.441170731320167 2024 3848840
SGTC_1268 0828-0275 2.46 µM 0.147958012385561 0.439008057972927 no 1446 0.441187952355224 2084 745337
SGTC_1697 st025554 27.742 µM 0.147766777607542 0.43908834208562 no 1447 0.441263414542413 2116 1269519
SGTC_615 k087-0205 167 µM 0.147572292422954 0.439169993352847 no 1448 0.441340161543187 2035 9642773
SGTC_1045 1348-1485 165 µM 0.147409256975388 0.439238442982169 no 1449 0.44140449966619 2148 6810614
SGTC_1742 st038235 28.8875 µM 0.147334449138903 0.439269851291928 no 1450 0.441434021345355 2026 564103 YBR002C RER2
SGTC_2390 9097792 176.6 µM 0.147181873035475 0.439333912042561 no 1451 0.44149423399717 1974 4497149
SGTC_2858 9025781 8.96 µM 0.14614972570506 0.439767312064887 no 1452 0.441901596187763 2145 4894980 YPL153C RAD53
SGTC_2692 st077426 47.7 µM 0.145953439665069 0.439849741017314 no 1453 0.441979072242377 2128 25238571
SGTC_482 fipronil 114 µM 0.145711129465924 0.439951501089987 no 1454 0.442074717551901 2154 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_657 3534-0529 86.7 µM 0.145702048360723 0.439955314848656 no 1455 0.442078302134958 2138 1049549
SGTC_2785 7756463 72.73 µM 0.145416212082901 0.440075359314743 no 1456 0.442191132661182 2064 2201551
SGTC_2092 5303694 80.6725 µM 0.145389862105311 0.440086425958676 no 1457 0.442201534242763 2021 1963699
SGTC_1107 amlodipine 47 µM 0.145150848509946 0.440186810661181 no 1458 0.442295886024982 2097 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1883 5-benzylidenerhodanine 20 µM 0.143696896936595 0.440797546794493 no 1459 0.44286991082717 2164 1273210
SGTC_440 fluspirilene 35.1 µM 0.143664916887499 0.440810981685446 no 1460 0.442882538006846 2093 3396 An atypical antipsychotic.
SGTC_1324 1418-0026 34.4 µM 0.143076477897942 0.441058198379322 no 1461 0.443114890857548 2068 1372513
SGTC_79 0052-0007 94.094 µM 0.141728344777048 0.441624666415417 no 1462 0.443647292520594 2129 2801472
SGTC_1008 4106-0037 6 µM 0.141694235622355 0.441639000193236 no 1463 0.443660764153874 2084 2905394
SGTC_673 1082-0474 110 µM 0.141357645612184 0.441780450374538 no 1464 0.443793706064275 2083 3098046
SGTC_2605 digitonin 300 nM 0.140679746638822 0.442065356369546 no 1465 0.444061472898881 2180 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1965 Pectolinarigenin 58.4 µM 0.140463554002279 0.442156223679339 no 1466 0.444146873327226 2052 5320438 An anti-inflammatory.
SGTC_1419 3993-2473 62.6 µM 0.140178093408621 0.442276209468284 no 1467 0.444259639960449 2070 704026
SGTC_3305 9127027 53.8275 µM 0.139622090418755 0.442509925769901 no 1468 0.444479292977928 2065 41905295
SGTC_181 1447-1644 8.07 µM 0.139176176343367 0.442697380571094 no 1469 0.444655466895802 2147 534600
SGTC_1653 st012112 65 µM 0.138625231372475 0.442929006312728 no 1470 0.444873152030929 2149 720429
SGTC_2941 9056145 11.23 µM 0.138185630703622 0.443113835191839 no 1471 0.44504685559147 2199 2119517
SGTC_2588 indole-3-carbinol 100 µM 0.137531186806069 0.44338901722917 no 1472 0.445305471722451 2162 3712 Induces cell cycle arrest.
SGTC_2312 7706453 155.7 µM 0.137428902002031 0.443432028643446 no 1473 0.445345893642118 2044 976098
SGTC_2319 6033012 152.6 µM 0.137368377028405 0.443457480095851 no 1474 0.445369812766939 2066 847246
SGTC_2600 tangeritin 87.95 µM 0.136303947682887 0.443905122993437 no 1475 0.445790501606312 2094 68077 A bioactive flavone.
SGTC_3184 9108758 49.47 µM 0.135392279877308 0.444288579366379 no 1476 0.446150863848286 2139 902885
SGTC_2908 7930301 100 µM 0.134782612398146 0.444545040578874 no 1477 0.446391876838887 2151 2223178
SGTC_1529 apigenin 74 µM 0.132551790605408 0.445483649663482 no 1478 0.447273930695671 2170 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_879 0831-1030 162 µM 0.132532136174182 0.445491920550544 no 1479 0.447281703108141 2077 1549252
SGTC_960 1222-0186 7.7 µM 0.130918200506551 0.446171170141713 no 1480 0.447920008340286 2104 3126296
SGTC_710 3448-4187 58 µM 0.130451650721304 0.446367554303457 no 1481 0.448104552155915 2113 3946412
SGTC_1380 2291-0730 164 µM 0.130284002491514 0.446438125458555 no 1482 0.448170868175747 2046 2999191
SGTC_1331 1472-0049 76.2 µM 0.129817406212056 0.44663454706481 no 1483 0.448355445642776 2087 24051409
SGTC_1505 k297-0037 20.6 µM 0.129685240740149 0.446690186740345 no 1484 0.448407730065168 2020 4089396
SGTC_656 4090-1979 187 µM 0.12924295095761 0.446876391711761 no 1485 0.448582705618091 2187 22330961
SGTC_276 colchicine 750 µM 0.128667336183248 0.44711874433216 no 1486 0.448810441234993 2081 2833 A microtubule depolymerizer.
SGTC_409 arachidonic acid 100 µM 0.128512599620052 0.447183896850797 no 1487 0.448871663923899 2158 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1830 st055982 50.3 µM 0.127619671190379 0.447559896131203 no 1488 0.449224981534208 2200 455313 An antimicrobial agent.
SGTC_490 phenamil 164 µM 0.127617525001399 0.447560799917332 no 1489 0.449225830795747 2173 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2989 9073649 71.4286 µM 0.127353287547341 0.447672075582975 no 1490 0.449330393124981 2216 21367202
SGTC_1048 3161-0300 24.5 µM 0.126384590567564 0.448080048373665 no 1491 0.449713749643171 2156 2165101
SGTC_3310 9130229 44.1445 µM 0.12583628667412 0.448310994357099 no 1492 0.449930758727607 2161 7761258
SGTC_162 k030-0015 37.8 µM 0.125628375618245 0.448398571224533 no 1493 0.450013050203419 2161 1809920 YMR134W ERG29
SGTC_1300 1094-0077 113 µM 0.124318301037401 0.448950462122224 no 1494 0.450531628786804 2073 5532636
SGTC_1836 st055642 81 µM 0.124266901125037 0.44897211721865 no 1495 0.450551976603304 2061 8571
SGTC_3080 9117754 49.47 µM 0.123761703709225 0.44918496804922 no 1496 0.450751977321598 2197 9550191
SGTC_2840 9008771 71.43 µM 0.123129589165714 0.449451312458703 no 1497 0.451002240393961 2186 2992978
SGTC_2114 5491910 81.25 µM 0.122769719418062 0.449602955436545 no 1498 0.451144726615864 2155 2849228
SGTC_2409 alverine citrate 63.97 µM 0.122484854506893 0.449722997874876 no 1499 0.451257520013946 2141 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_923 1900-2434 73.3 µM 0.120269209411271 0.450656829781409 no 1500 0.452134947182377 2195 5910570
SGTC_3204 9114183 49.47 µM 0.119868407980044 0.450825785610924 no 1501 0.452293695385925 2079 17027248
SGTC_260 nsc-65238 3.989 µM 0.118798523504842 0.451276833592271 no 1502 0.452717489236822 2175 3246252
SGTC_2689 tacrolimus 100 µM 0.118452524477846 0.451422715321093 no 1503 0.452854555079972 2067 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_354 2783-3500 4.88 µM 0.117135070640746 0.451978246255731 no 1504 0.453376509333778 2043 6740761
SGTC_1851 st056236 18.9 µM 0.116306686230084 0.452327599444595 no 1505 0.453704743366251 2211 5393171
SGTC_548 1436-0017 110 µM 0.115727406592505 0.452571920036557 no 1506 0.453934292432494 2198 9677137
SGTC_528 3492-0019 172 µM 0.115727185305337 0.45257201337145 no 1507 0.453934380124112 2197 2869262
SGTC_1385 3091-4834 14.1 µM 0.114884262434681 0.45292756184141 no 1508 0.454268429626434 2142 4072814
SGTC_395 anisomycin 6.25 µM 0.114733815655814 0.452991024913384 no 1509 0.454328054945535 2087 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1007 4101-0031 70 µM 0.113886649044383 0.453348408180043 no 1510 0.454663824611085 2209 1146276
SGTC_588 3970-1144 52.9 µM 0.113651746211211 0.453447510316242 no 1511 0.454756932759353 2212 1888707
SGTC_1161 k007-0610 110 µM 0.11294177920882 0.453747052809104 no 1512 0.455038356599618 2214 5843850
SGTC_2395 5646831 180.19 µM 0.112199684086063 0.454060178615617 no 1513 0.455332539825959 2154 6808628
SGTC_1022 4477-0945 21.3 µM 0.111240521797957 0.45446493783201 no 1514 0.455712809635239 2125 4648966
SGTC_2084 5306078 60.6385 µM 0.111107670594725 0.454521003770896 no 1515 0.45576548307586 2139 679340
SGTC_3287 9117173 37.0625 µM 0.110887867996488 0.454613766975201 no 1516 0.455852633102289 2238 2789709
SGTC_2769 toremifene 3.73 µM 0.110618105493965 0.45472761812098 no 1517 0.45595959474634 2162 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2382 9035899 200 µM 0.110134203462652 0.454931854486538 no 1518 0.456151471350933 2157 6462679
SGTC_621 3584-0052 32.1 µM 0.10858441567562 0.455586039994175 no 1519 0.456766061073599 2210 2273927
SGTC_2956 9076196 2.52 µM 0.108212869935315 0.455742892230872 no 1520 0.456913418087467 2236 16423868
SGTC_2006 4011487 200 µM 0.107788905273678 0.455921882133487 no 1521 0.457081571960327 2193 45595294
SGTC_2853 9015042 58.44 µM 0.106777458683097 0.456348931914259 no 1522 0.45748276529285 2174 6457456
SGTC_1825 st052143 62.6 µM 0.105744029892732 0.45678531502901 no 1523 0.457892722681928 2213 674173
SGTC_3217 9129673 49.47 µM 0.105720245418 0.456795359048906 no 1524 0.457902158424408 2147 17248312
SGTC_2402 5553605 200 µM 0.102602234300384 0.458112310268304 no 1525 0.459139334742879 2176 6758546
SGTC_1615 st002656 86.5 µM 0.102260010115554 0.458256883427581 no 1526 0.459275148080853 2235 1584458
SGTC_369 0957-0393 4.5 µM 0.101340150312385 0.458645507004599 no 1527 0.459640222446493 2125 6997992
SGTC_2463 5473429 200 µM 0.101136804986213 0.458731421952981 no 1528 0.459720930833521 2132 5399405
SGTC_1569 carminic acid 40.6 µM 0.100316412862553 0.459078063407908 no 1529 0.460046563820288 2229 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3096 9117468 49.47 µM 0.0999174464001336 0.459246650538628 no 1530 0.460204932719968 2235 41316311
SGTC_321 4534-3890 65.3 µM 0.0991096887172479 0.45958799875525 no 1531 0.460525589740787 2229 699746
SGTC_2780 5215298 71.43 µM 0.0975759945668505 0.460236200353288 no 1532 0.461134493542449 2262 2834131
SGTC_2080 5212524 12.4 µM 0.0973429651649341 0.460334697358998 no 1533 0.461227018361587 2258 260183
SGTC_1144 3486-0183 12.5 µM 0.0972830919803138 0.460360004985425 no 1534 0.461250791475858 2147 6744069
SGTC_3101 9120531 49.47 µM 0.0944086645487975 0.461575175585099 no 1535 0.462392266617313 2238 24824904
SGTC_1074 carmofur 3.8 µM 0.093919740603956 0.461781905290733 no 1536 0.462586456208064 2234 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1722 st034304 3.6505 µM 0.0912707014220602 0.462902165779237 no 1537 0.463638748837835 2174 4036148 YLR033W RSC58
SGTC_2743 auranofin 4.32 µM 0.0907378127562545 0.463127556578727 no 1538 0.463850462156237 2208 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_262 fenpropimorph 62.5 µM 0.0904539230018357 0.463247635538289 no 1539 0.463963253955174 2230 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_764 1951-2361 146 µM 0.0900686449091394 0.463410604831011 no 1540 0.464116332828914 2100 5438930
SGTC_2251 lansoprazole 556 µM 0.089803757510122 0.463522653467922 no 1541 0.464221581098356 2049 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2836 9010338 19.48 µM 0.089176501978988 0.463787997081421 no 1542 0.464470819833335 2129 2994051
SGTC_653 0203-0016 55.2 µM 0.0890295521203036 0.463850162607562 no 1543 0.46452921208607 2190 295302
SGTC_3118 9124250 49.47 µM 0.0881313685563404 0.464230148442346 no 1544 0.464886132435517 2135 1504786
SGTC_1735 st034310 56.75 µM 0.0861683081137912 0.465060754553826 no 1545 0.465666311719862 2173 871153
SGTC_1241 0364-0022 50.8 µM 0.0847575402524765 0.465657769999701 no 1546 0.466227074994655 2205 4563895
SGTC_306 1672-3436 11.6 µM 0.0838817658960349 0.46602842332566 no 1547 0.466575218583711 2196 6797378
SGTC_1824 st053723 68.6 µM 0.083855717451504 0.466039448242237 no 1548 0.466585573925892 2152 675225
SGTC_1105 epirubicin 18.1 µM 0.0836399654191802 0.466130765565719 no 1549 0.466671345218381 2187 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1219 1469-0211 33.1 µM 0.0826179974717683 0.466563338952554 no 1550 0.467077645142999 2262 6822282
SGTC_3133 9127736 49.47 µM 0.0815023923083654 0.467035591700342 no 1551 0.467521211211614 2278 27243420
SGTC_2755 lomerizine 42.69 µM 0.0813399668519093 0.467104352769114 no 1552 0.467585795161651 2207 3949 A calcium channel blocker.
SGTC_944 3370-0224 231 µM 0.0779119183360897 0.468555806021354 no 1553 0.468949059385199 2208 4580514
SGTC_2400 5203494 178.7 µM 0.0768510282375049 0.469005077916561 no 1554 0.469371028036123 2267 6777674
SGTC_1678 st019265 80.2 µM 0.0766559761613807 0.469087684014138 no 1555 0.469448613686721 2279 5367020
SGTC_642 0335-0876 158 µM 0.0763656014516559 0.469210662465317 no 1556 0.469564117864937 2209 6812350
SGTC_3077 9117319 49.47 µM 0.0762499232498672 0.469259654899543 no 1557 0.469610132626223 2290 17154678
SGTC_3240 9133527 49.47 µM 0.0744285595447602 0.470031106068532 no 1558 0.470334692294851 2243 17617455
SGTC_1135 dihydrocapsaicin 536.708 nM 0.074252774328684 0.47010556710913 no 1559 0.470404626934371 2237 107982 A Capsaicinoid.
SGTC_654 1124-0271 80.9 µM 0.0736201578878803 0.470373546390188 no 1560 0.470656315494199 2199 5403748
SGTC_845 0330-0138 4.51 µM 0.0733195336958523 0.47050089691357 no 1561 0.470775923946107 2276 9039800
SGTC_1042 0350-0096 82 µM 0.0721428113438586 0.470999409336658 no 1562 0.471244128219575 2199 3122515
SGTC_1416 3966-0321 25.3 µM 0.0719001512863412 0.471102216710438 no 1563 0.471340684826935 2238 582530 YLR208W SEC13
SGTC_1445 4239-0156 97.7 µM 0.0697776300409885 0.472001543018438 no 1564 0.472185326205776 2275 4008346
SGTC_2585 alliin 100 µM 0.0695093200114377 0.47211523801438 no 1565 0.472292107151052 2238 87310 A garlic compound which reacts with lipids.
SGTC_57 miconazole 162.5 nM 0.0687774541957615 0.472425373917082 no 1566 0.472583382263987 2287 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2010 4012422 159 µM 0.0658847646195044 0.473651343634766 no 1567 0.473734785149261 2252 952393
SGTC_2385 9074692 200 µM 0.0658432242611306 0.473668950971819 no 1568 0.473751321447855 2143 17046906
SGTC_133 0724-0033 378.92 µM 0.0657723501150411 0.473698991875643 no 1569 0.473779534983439 2301 280309
SGTC_60 0986-0278 202 µM 0.0652795394343404 0.473907880046191 no 1570 0.473975716378744 2157 3110598
SGTC_1882 5615643 20 µM 0.0649907835087997 0.474030278654612 no 1571 0.474090669218099 2305 2253075
SGTC_2306 7482397 179.52 µM 0.0649226411163572 0.474059163386086 no 1572 0.474117796808384 2263 891448
SGTC_2093 5331342 194.4 µM 0.0633962495250771 0.474706217676741 no 1573 0.47472548684558 2290 33839
SGTC_2447 5741742 33.78 µM 0.062768993710357 0.474972137800233 no 1574 0.474975228299217 2243 1776504
SGTC_2860 9025725 38.96 µM 0.0624810300666221 0.47509422144257 no 1575 0.475089884117065 2216 40546248
SGTC_403 arphamenine a 50 µM 0.062003794414416 0.475296553053245 no 1576 0.475279905155964 2292 5487158 An arginine aminopeptidase inhibitor.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0612581747596794 0.475612683043751 no 1577 0.475576799959312 2228 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_568 1193-0097 7.48 µM 0.0583038310871376 0.476865423271208 no 1578 0.476753307971116 2289 3646150
SGTC_837 0091-0265 12.5 µM 0.058184853656281 0.476915878541932 no 1579 0.476800692656482 2233 759367
SGTC_456 gingerol 170 µM 0.0573748929026116 0.477259371875104 no 1580 0.477123281304779 2254 442793 A herb.
SGTC_2045 5106652 78.05 µM 0.0560391808175817 0.47782586597908 no 1581 0.477655297203834 2295 673349
SGTC_222 nsc-310342 10.666 µM 0.0550559255168551 0.478242906946771 no 1582 0.478046954598184 2308 432556
SGTC_95 0471-0001 561.058 µM 0.0536228179787056 0.478850792188074 no 1583 0.478617838272916 2234 4015405
SGTC_3241 9133421 49.47 µM 0.0508109759216904 0.48004364076843 no 1584 0.479738072327716 2308 17018221
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.050438341292174 0.480201734660755 no 1585 0.479886541661 2295 2333 A French combination drug.
SGTC_2507 purpurin 79.67 µM 0.0491505807332669 0.480748103515559 no 1586 0.480399647245436 2325 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_307 1501-1223 22.3 µM 0.0488269179574438 0.480885432334213 no 1587 0.48052861516296 2275 2830329
SGTC_2033 5192550 145 µM 0.0484916422893862 0.481027690848352 no 1588 0.480662212547286 2287 182073
SGTC_2497 7-hydroxyflavone 100 µM 0.0475311953116853 0.481435224815713 no 1589 0.481044934080785 2308 5281894
SGTC_63 0099-0242 26.702 µM 0.0474965973279175 0.481449905692523 no 1590 0.481058721107947 2325 3898502 YLR359W ADE13
SGTC_1362 1611-0397 101 µM 0.0470875531124655 0.481623476313395 no 1591 0.48122172375595 2308 27816
SGTC_3257 9139206 32.98 µM 0.0466367095678017 0.481814787768848 no 1592 0.481401386922407 2312 4910041
SGTC_85 0868-0259 160.055 µM 0.0464511600751596 0.481893525267646 no 1593 0.481475330323435 2273 83173
SGTC_1199 1638-0010 4.46 µM 0.0459735318069642 0.48209620896207 no 1594 0.481665673077398 2294 3111136
SGTC_2038 4100038 30.985 µM 0.0438038737490777 0.483016970552509 no 1595 0.482530369622384 2283 3596803
SGTC_3131 9127911 49.47 µM 0.0431676018606363 0.483287009630315 no 1596 0.482783965486769 2284 45595681
SGTC_1715 st032160 10.2275 µM 0.0423675784553318 0.483626557078083 no 1597 0.483102836888031 2313 5289825
SGTC_2954 9074818 52.69 µM 0.041844613422591 0.483848521320627 no 1598 0.483311284885307 2305 16648742
SGTC_2217 6934799 96.0675 µM 0.0414566736469231 0.484013179464475 no 1599 0.483465916279491 2323 675606
SGTC_674 0498-0004 451 µM 0.0413021430156349 0.484078769599031 no 1600 0.483527512325206 2287 4231473
SGTC_1781 st038725 66.3 µM 0.0405767151467088 0.484386681347417 no 1601 0.483816673743007 2286 4270275 YIL048W NEO1
SGTC_2543 pimpinellin 60.67 µM 0.0405141258239496 0.484413248159973 no 1602 0.483841622754495 2329 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1849 st056239 19.2 µM 0.0404170375210177 0.484454458628439 no 1603 0.4838803236848 2285 5393181
SGTC_3336 9143619 71.43 µM 0.0404107357710612 0.484457133498816 no 1604 0.483882835667073 2337 45595730
SGTC_1174 0739-0097 51.1 µM 0.0394275681827322 0.484874461920942 no 1605 0.48427475038094 2288 728447
SGTC_2946 9065502 71.43 µM 0.0386188514585725 0.485217753043162 no 1606 0.484597136106573 2340 16489101
SGTC_302 1094-0063 18.9 µM 0.0384458800371765 0.485291178890305 no 1607 0.484666090510986 2319 5440289
SGTC_2620 irigenin 100 µM 0.0382472443856307 0.485375499740854 no 1608 0.484745276429428 2320 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2558 carylophyllene oxide 100 µM 0.0381117072656119 0.485433035635094 no 1609 0.484799308522227 2344 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_453 enantio-paf c16 10 µM 0.0380306528093101 0.485467443628088 no 1610 0.484831621146168 2328 13871343 A lipid and platelet activating factor
SGTC_2894 9048625 32.47 µM 0.0378584087043107 0.48554056240925 no 1611 0.484900287152094 2334 4092861
SGTC_1057 3448-5381 134 µM 0.0375823067513552 0.485657770558664 no 1612 0.485010357561134 2327 5497911
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0373814069562243 0.485743055389641 no 1613 0.48509044870403 2308 5379071
SGTC_1157 4092-0394 27.6 µM 0.036860922744137 0.48596401139148 no 1614 0.485297948845297 2341 3659885
SGTC_117 lucigenin 22.078 µM 0.0359885764249558 0.4863343495543 no 1615 0.485645733873562 2271 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_439 amiodarone 34.4 µM 0.0356317911231386 0.486485819433314 no 1616 0.48578797937985 2277 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1578 josamycin 24.2 µM 0.034398697849877 0.487009332580768 no 1617 0.486279610912021 2290 5282165 A P450 substrate.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0333335617094196 0.487461557118152 no 1618 0.486704295124634 2316 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1298 1079-1278 263 µM 0.0316797952734302 0.488163727983836 no 1619 0.487363703917294 2351 2840950
SGTC_3297 9117502 71.43 µM 0.0315943688251825 0.488200000120483 no 1620 0.48739776708809 2369 7453720
SGTC_2586 curcumin 80 µM 0.0305621891435306 0.488638272046153 no 1621 0.487809348372976 2340 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_36 0335-0881 14.2 µM 0.0301208437710735 0.488825675115373 no 1622 0.487985338673228 2330 23828853
SGTC_2564 betulinic acid 100 µM 0.0294521671047375 0.48910961176907 no 1623 0.488251983747599 2353 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3053 9095903 49.47 µM 0.0275242014286401 0.489928304080723 no 1624 0.489020818604416 2357 17174018
SGTC_3143 9086658 49.47 µM 0.0273364022862085 0.490008053526309 no 1625 0.489095711441655 2298 25236626
SGTC_2432 5630864 12.22 µM 0.0273237379382935 0.490013431492462 no 1626 0.489100761898964 2334 5714970
SGTC_3212 9128307 49.47 µM 0.0271544875805202 0.490085304509828 no 1627 0.489168257977919 2282 27243542
SGTC_891 0929-0073 133 µM 0.0259368118576285 0.49060240599007 no 1628 0.489653869149282 2340 5603632
SGTC_1666 st014829 29 µM 0.0259115626042443 0.490613128576758 no 1629 0.489663938759728 2346 3858230
SGTC_157 1348-1695 65.819 µM 0.0258094097649476 0.490656509836566 no 1630 0.489704678221533 2362 5380510
SGTC_1801 st050089 28.441 µM 0.0251283337569366 0.490945745275345 no 1631 0.489976300122163 2352 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1400 3771-8998 51.5 µM 0.0250134879621509 0.490994517799658 no 1632 0.490022102568565 2336 670767
SGTC_483 fpl-64176 144 µM 0.0248270181121632 0.491073707797064 no 1633 0.490096470180202 2360 3423
SGTC_1187 1391-0724 117 µM 0.0238973817488337 0.491468510863235 no 1634 0.490467231374762 2310 6997986
SGTC_3110 9122132 49.47 µM 0.0238935277496098 0.491470147618414 no 1635 0.490468768459106 2348 918317
SGTC_1494 4358-1428 177 µM 0.0233743202489402 0.491690651187061 no 1636 0.490675844440598 2370 1564571
SGTC_2420 aureobasidin a 50 nM 0.0230420868360342 0.491831749586076 no 1637 0.490808350705244 2346 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1896 st058441 89 µM 0.0229146162443409 0.49188588618452 no 1638 0.490859190690099 2313 688759
SGTC_1378 2093-0007 380 nM 0.0226028153699302 0.492018308247883 no 1639 0.490983549031023 2336 3618014
SGTC_3029 9088683 49.47 µM 0.022085672125365 0.492237941300971 no 1640 0.491189807838653 2337 25236615
SGTC_2161 5662504 8.5105 µM 0.0218413336833906 0.492341713754726 no 1641 0.491287261265262 2340 2859334
SGTC_3097 9117246 49.47 µM 0.0216886961817103 0.492406540362985 no 1642 0.491348140396784 2367 16423892
SGTC_2544 sphondin 68.51 µM 0.0210581045774975 0.492674360761178 no 1643 0.491599652590461 2357 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1691 st019933 84.6 µM 0.0200990354455445 0.493081696097988 no 1644 0.491982184796892 2375 6176082
SGTC_863 0466-0191 129 µM 0.0199669179829045 0.493137809532069 no 1645 0.492034881463502 2374 765160 YPR165W RHO1
SGTC_1342 1486-1464 234 µM 0.0196762501609792 0.493261263557637 no 1646 0.492150818369048 2369 3253938
SGTC_2598 perillyl alcohol 100 µM 0.0192780183068251 0.493430403812251 no 1647 0.49230965976023 2352 10819 An apoptosis inducer.
SGTC_308 4092-1169 104 µM 0.0191779970335532 0.493472885843337 no 1648 0.492349555099401 2365 2268590 YDL196W YDL196W
SGTC_2667 digitoxin 100 µM 0.0180653878211066 0.493945449188238 no 1649 0.492793344980315 2372 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2506 ethyl hematommate 54.16 µM 0.0162498587709028 0.494716584674714 no 1650 0.493517529578256 2330 3940691 An allergen.
SGTC_154 3389-1638 511.116 µM 0.0159301652737588 0.494852374768948 no 1651 0.493645052322339 2327 5238686
SGTC_2028 5153890 36.43 µM 0.0143303090452438 0.495531923755336 no 1652 0.494283229495165 2378 2830968 YPR165W RHO1
SGTC_2258 7960471 200 µM 0.013498742281453 0.495885142209372 no 1653 0.494614944512766 2352 2974708
SGTC_2897 9048598 12.99 µM 0.013282567808996 0.495976965578122 no 1654 0.494701177918018 2379 6467404
SGTC_275 trichlorophene 5.69 µM 0.0125841708331489 0.49627362166273 no 1655 0.494979774692826 2337 62616
SGTC_1 0258-0098 57.368 µM 0.0122440472182958 0.496418095753467 no 1656 0.495115453927527 2311 6790032 YDR047W HEM12
SGTC_1128 3448-9350 235 µM 0.0114892840280552 0.496738697682357 no 1657 0.495416539668803 2345 619386
SGTC_2294 7971431 200 µM 0.0110091543463179 0.496942644219834 no 1658 0.495608071578005 2379 5741572
SGTC_2869 9037858 32.47 µM 0.0109460868425642 0.496969433707267 no 1659 0.495633230355803 2384 27187042
SGTC_401 neomycin 50 µM 0.00973155712588256 0.497485337869014 no 1660 0.496117731685648 2337 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1693 xanthone 101.9 µM 0.00928779947761724 0.497673836959424 no 1661 0.496294757367591 2379 7020 An insecticide.
SGTC_134 0269-0018 6.916 µM 0.00923292870539769 0.497697144967934 no 1662 0.496316646700012 2376 4378915
SGTC_1253 0550-0034 176 µM 0.0084297864950405 0.498038304601868 no 1663 0.496637041581785 2374 5969915
SGTC_1437 4092-1038 11.6 µM 0.00839507682038653 0.498053048649884 no 1664 0.496650888248577 2385 3977136
SGTC_70 0141-0289 43.283 µM 0.00831838173261393 0.498085627358682 no 1665 0.496681484093433 2347 352408
SGTC_1754 st042065 16.137 µM 0.00809193699441325 0.498181817128442 no 1666 0.496771819432534 2381 1126236 YIL048W NEO1
SGTC_1753 st043925 64 µM 0.0079346678831777 0.498248622362606 no 1667 0.496834558715971 2390 670181
SGTC_1972 st070201 17.4 µM 0.00740577086536691 0.498473289137969 no 1668 0.4970455518892 2392 2829099
SGTC_330 1488-0319 80.1 µM 0.00690138785985251 0.498687543215196 no 1669 0.497246766444971 2379 6846614
SGTC_37 0566-0070 1.56 µM 0.00612295139713485 0.499018211671175 no 1670 0.497557311069801 2393 1626686
SGTC_315 k915-0449 187 µM 0.00576956252203802 0.499168326347445 no 1671 0.497698290340375 2388 20970215 YNL149C PGA2
SGTC_1945 st075991 56.6 µM 0.0057584722243137 0.499173037353599 no 1672 0.497702714655542 2383 1084980
SGTC_1523 st012844 44.7 µM 0.00571396366849433 0.499191943977964 no 1673 0.49772047070817 2376 4274103
SGTC_1816 st051957 91.6 µM 0.00523568227283961 0.499395111464125 no 1674 0.497911274517439 2393 674121
SGTC_1258 0671-0043 57.1 µM 0.0052260956407478 0.499399183737919 no 1675 0.497915098977984 2389 4298767
SGTC_3083 9117465 49.47 µM 0.00461732500389028 0.49965778151692 no 1676 0.498157960378881 2391 16420915
SGTC_2844 9010103 25.97 µM 0.00444763155718868 0.499729865096854 no 1677 0.498225657574029 2389 2480525
SGTC_2898 9056270 58.44 µM 0.00382849956047896 0.49999286441323 no 1678 0.498472653385985 2397 19154699
SGTC_2895 9054447 58.44 µM 0.00379490350556036 0.49999286441323 no 1679 0.498486056175381 2399 2697450
SGTC_1193 1488-0126 41.5 µM 0.00372192601067601 0.499961864508786 no 1680 0.498515169777976 2398 1384710
SGTC_527 4476-4215 268 µM 0.00280270844973799 0.499571392752564 no 1681 0.498881882563596 2385 4418754
SGTC_3277 9138724 49.47 µM 0.00273930751719339 0.499544460865545 no 1682 0.498907175779094 2394 15943418
SGTC_2370 9071495 200 µM 0.00131989924638183 0.498941515567029 no 1683 0.499473436537639 2398 21791103
SGTC_4 0960-0234 25.671 µM 0.000942691176231289 0.498781283067039 no 1684 0.499623920688141 2338 6821112
SGTC_2626 ethyl orsellinate 100 µM 0.000767078215906554 0.498706685302084 no 1685 0.499693980097311 2405 75653 A natural product.
SGTC_519 k048-0011 62.8 µM 0 0.498380842487207 no 1686 0.5 2406 6836379
SGTC_1198 1612-1005 86.7 µM -0.000384385847078969 0.498217561790904 no 1687 0.499846652237389 2403 6998509
SGTC_929 2805-0021 398 µM -0.000976947273538792 0.497965852175447 no 1688 0.49961025448886 2415 3098024
SGTC_153 4077-0274 519.67 µM -0.00107145581907959 0.497925706688815 no 1689 0.499572551053973 2407 3121976
SGTC_1379 2144-0755 36.5 µM -0.00147706189135936 0.497753412955605 no 1690 0.499410737775034 2409 5392327
SGTC_2176 5809774 33.9695 µM -0.00173580607477498 0.497643503572138 no 1691 0.499307513913941 2414 2870539
SGTC_926 2268-1401 59.4 µM -0.00216288944174312 0.497462087446492 no 1692 0.499137132626617 2410 2931578
SGTC_1015 4130-4525 82 µM -0.00264215820091943 0.497258504679103 no 1693 0.498945932608551 2414 1363237
SGTC_727 3032-0951 202 µM -0.0028508431977058 0.497169860128611 no 1694 0.498862679654199 2420 3652836
SGTC_819 1013-0258 27.7 µM -0.00285414225569261 0.497168458766342 no 1695 0.498861363525837 2411 5753198
SGTC_2851 9015922 71.43 µM -0.00288748276699128 0.497154296502974 no 1696 0.498848062641041 2412 2996893
SGTC_3324 9138759 60.749 µM -0.00388714230095665 0.496729666440694 no 1697 0.498449258491464 2434 45595710
SGTC_432 NS 1619 61.3 µM -0.00424446879777474 0.496577884064966 no 1698 0.498306707022982 2461 4552 A K+/calcium channel activator.
SGTC_1604 st002052 72.4 µM -0.00434152170311906 0.49653665876979 no 1699 0.498267988872405 2449 6254834 YHR062C RPP1
SGTC_515 4092-1064 102 µM -0.00475852217726695 0.496359529335119 no 1700 0.498101631475558 2415 717353
SGTC_830 4076-0286 57.8 µM -0.00592767537866646 0.495862911666992 no 1701 0.497635213515679 2419 6866659
SGTC_1516 st013856 110 µM -0.00597325707524059 0.495843550192502 no 1702 0.497617029371641 2453 5281404 A mutagen and neurotoxin.
SGTC_2843 9000894 45.46 µM -0.00649701365831783 0.495621077842023 no 1703 0.49740808479 2417 2242070
SGTC_2366 9070441 60.58 µM -0.00734196253864533 0.495262177829363 no 1704 0.497071007036509 2424 6837235
SGTC_2201 6605497 169.863 µM -0.00846329856213064 0.494785885739164 no 1705 0.496623672678224 2441 670741
SGTC_2380 9035439 200 µM -0.00851005614454902 0.494766025420345 no 1706 0.496605019773407 2468 6462575
SGTC_3057 9095946 49.47 µM -0.00939248472931755 0.494391215693122 no 1707 0.496252995816214 2423 24540043
SGTC_2918 7977171 22.06 µM -0.00945802583175177 0.494363377438068 no 1708 0.496226849860723 2422 2236483
SGTC_90 0870-0863 4.608 µM -0.0104191776963472 0.493955136220518 no 1709 0.49584342469584 2424 1738164
SGTC_1563 conessine 56.1 µM -0.0110108363501337 0.493703837275406 no 1710 0.495607400596236 2428 441082 An anti-amoebic, histamine inhibitor.
SGTC_103 0844-0104 51.839 µM -0.0113469937093818 0.49356106012775 no 1711 0.495473301592709 2444 5375804
SGTC_2224 6650123 117.647 µM -0.0117037544261824 0.49340953295542 no 1712 0.495330984112177 2421 2908370
SGTC_317 4495-0002 170 µM -0.0120963765124373 0.493242775464208 no 1713 0.495174361652924 2437 15991618
SGTC_2423 st077119 87.2 µM -0.0122398130252828 0.493181854291298 no 1714 0.495117142999572 2406 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_215 1287-0124 461.5 µM -0.0153142676282233 0.49187609497781 no 1715 0.493890729948571 2483 5560863
SGTC_3176 9106582 49.47 µM -0.0163740719102318 0.491426002314423 no 1716 0.493467982297442 2424 17018027
SGTC_2779 methotrexate 400 µM -0.0163818395324504 0.491422703490419 no 1717 0.493464883880104 2430 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1571 st070080 73.4 µM -0.0165867764915429 0.491335669223114 no 1718 0.493383136969845 2438 4315245
SGTC_2474 5321570 43.32 µM -0.0170022521267227 0.491159222976727 no 1719 0.493217409547518 2505 2841384
SGTC_1183 1254-0324 198 µM -0.0181025220956959 0.490691963336176 no 1720 0.492778532970309 2452 5799357
SGTC_2811 7967822 32.47 µM -0.0181213283070779 0.490683976874975 no 1721 0.492771031607936 2462 2232244
SGTC_3138 9097216 49.47 µM -0.0184297792813197 0.490552987085453 no 1722 0.492647998021438 2431 25237486
SGTC_3173 9105693 49.47 µM -0.0200337584164587 0.489871842454972 no 1723 0.492008221321264 2461 17096658
SGTC_2412 st077135 33.4 µM -0.0206290879795434 0.489619037639052 no 1724 0.491770768273954 2582 13258915
SGTC_1608 st001473 40.5 µM -0.0210700591880386 0.489431783293126 no 1725 0.49159488444879 2449 7292267
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0212505344394908 0.48935514681591 no 1726 0.491522901357829 2441 140250 A respiratory chain inhibitor.
SGTC_1368 1852-0141 284 µM -0.0225438089585899 0.488805986216208 no 1727 0.491007083186587 2448 2838987
SGTC_799 1310-0557 151 µM -0.0227272513062807 0.488728093149576 no 1728 0.49093391902404 2520 5354492
SGTC_361 000s-0510 1.45 µM -0.0227603984190185 0.488714018308645 no 1729 0.490920698659065 2465 660
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0227768411394849 0.488707036448594 no 1730 0.490914140662752 2431 6708561
SGTC_1204 4049-0315 18.3 µM -0.0235507566170627 0.488378422665567 no 1731 0.490605475884929 2553 588402
SGTC_3304 9125678 46.087 µM -0.0236754188347678 0.488325490326464 no 1732 0.490555756718637 2456 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3339 9145883 14.936 µM -0.0247924155223992 0.487851215996531 no 1733 0.490110270368455 2464 2030670
SGTC_1191 1487-1166 10.6 µM -0.0262290128519108 0.487241265289717 no 1734 0.489537337464764 2509 3955771
SGTC_146 3448-8650 53.125 µM -0.0263533220834073 0.487188487440318 no 1735 0.489487762393245 2492 2891488 YIL048W NEO1
SGTC_1146 3579-1023 7 µM -0.0267847479278734 0.487005319136111 no 1736 0.489315709122456 2523 X1146
SGTC_29 0299-0004 12.984 µM -0.0281429314679436 0.486428700050377 no 1737 0.48877407663045 2456 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2440 5628896 157.78 µM -0.0286181297120694 0.486226960482129 no 1738 0.488584576293399 2478 5522048
SGTC_1805 st050013 60.3 µM -0.0291255991935482 0.486011524450324 no 1739 0.488382209625838 2483 4037144
SGTC_2132 5317594 122.667 µM -0.0296213349856856 0.485801073663561 no 1740 0.488184524960088 2466 794577
SGTC_811 0416-0114 265 µM -0.0307446558286955 0.485324213893572 no 1741 0.487736588889212 2504 6612453
SGTC_600 1495-0418 41.6 µM -0.0307772710082113 0.485310368767643 no 1742 0.487723583469681 2469 5377768
SGTC_1767 st044992 70.3 µM -0.0309298454065387 0.485245601254163 no 1743 0.487662744056031 2483 9600693
SGTC_3128 9127691 49.47 µM -0.0313786076154939 0.485055104896036 no 1744 0.487483800699551 2543 41316314
SGTC_594 1487-1584 10.8 µM -0.0326754293017523 0.484504632659202 no 1745 0.486966709001205 2464 5013332
SGTC_1951 sophoraflavanone G 9.2 µM -0.0328439897678413 0.48443308460103 no 1746 0.486899499178977 2467 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2307 7538926 6.34 µM -0.0328747085532977 0.48442004559841 no 1747 0.486887250770971 2492 96582
SGTC_2647 atorvastatin 60.16 µM -0.0333455820993445 0.484220179067001 no 1748 0.486699502347257 2498 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1006 4099-6547 255 µM -0.0335334987643719 0.484140417244548 no 1749 0.486624576347442 2507 3146833
SGTC_2056 5235370 200 µM -0.0335660064478234 0.484126619319853 no 1750 0.48661161495471 2482 5511916
SGTC_3158 9100007 49.47 µM -0.0336409335576739 0.484094816491866 no 1751 0.486581740234577 2478 19297233
SGTC_1780 st038448 24.544 µM -0.034831239204591 0.483589604708586 no 1752 0.486107155227762 2588 728868 YDL195W SEC31
SGTC_525 k781-2675 26.7 µM -0.0348772024142407 0.483570096666666 no 1753 0.486088829694554 2463 3651118 YDL195W SEC31
SGTC_2326 6164455 177.58 µM -0.0359151120929988 0.483129590003743 no 1754 0.485675022966966 2500 2888790
SGTC_2166 5933061 31.504 µM -0.0361849269088373 0.483015079320569 no 1755 0.485567452351686 2576 2877375
SGTC_3146 9095609 49.47 µM -0.0365686985414419 0.482852207241633 no 1756 0.485414450887172 2506 17173999
SGTC_397 arbidol 50 µM -0.0369248862580969 0.482701044293252 no 1757 0.485272448455203 2575 131410 A RNA synthesis inhibitor.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0371656341914154 0.482598874385282 no 1758 0.485176469806727 2491 2374 Ca(2+)-ATPase inhibitor.
SGTC_1454 4239-0054 42.6 µM -0.0372579406480947 0.48255970117545 no 1759 0.48513967034566 2588 1340767
SGTC_2280 7785178 200 µM -0.0390489808803318 0.481799649509876 no 1760 0.484425668637002 2488 2954328
SGTC_629 3448-6466 76.7 µM -0.0390935499841537 0.481780736851902 no 1761 0.484407901703445 2480 573744
SGTC_2516 gossypol 71.55 µM -0.0392102558287205 0.481731213552806 no 1762 0.484361378478434 2498 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_311 1315-0136 58 µM -0.0396599092472053 0.481540408949645 no 1763 0.484182132149273 2507 6759207
SGTC_623 k072-0108 16.9 µM -0.0404230516225603 0.48121658907017 no 1764 0.483877926364563 2531 5382803
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0413886800884026 0.480806867204492 no 1765 0.483493018523266 2519 688761
SGTC_2203 7227154 166.4 µM -0.0416812757601009 0.48068272111418 no 1766 0.483376390383353 2490 896304
SGTC_115 0527-0192 112.043 µM -0.0419216554059417 0.480580731282861 no 1767 0.48328057652686 2518 4233931
SGTC_2076 5212012 200 µM -0.0425920162801128 0.480296312970749 no 1768 0.483013379901066 2475 604802
SGTC_1924 st058459 75.1 µM -0.0431162635363158 0.480073894203667 no 1769 0.482804427463895 2484 688683
SGTC_1740 st038286 13.222 µM -0.0431176782508812 0.48007329400084 no 1770 0.482803863598817 2523 716786
SGTC_1817 st052116 64.4 µM -0.0437057227291959 0.479823815830788 no 1771 0.482569488749696 2502 4361398
SGTC_1420 4'-methoxyflavone 42 µM -0.0458399475590018 0.478918436970244 no 1772 0.481718909356469 2480 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0473343178279494 0.478284561077685 no 1773 0.481123388527308 2594 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3221 9128209 49.47 µM -0.0483122929938505 0.477869757191396 no 1774 0.480733678801291 2525 16460723
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0483525656663006 0.477852676224488 no 1775 0.480717631084381 2481 368090
SGTC_1655 st012546 55.1 µM -0.0485902525306094 0.477751866225941 no 1776 0.480622919072183 2548 720985 YLR208W SEC13
SGTC_1078 idebenone 36.1 µM -0.0492544631816292 0.477470162497028 no 1777 0.480358254278819 2531 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1088 bifonazole 369 nM -0.049569164796288 0.477336695782303 no 1778 0.480232859670196 2467 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1471 k673-0312 37 µM -0.0500529777481619 0.477131512966961 no 1779 0.480040085528257 2507 24099884
SGTC_748 act1.228 77.9 µM -0.0500794370850508 0.477120291859995 no 1780 0.480029543001426 2495 4421505 YNR035C ARC35
SGTC_1225 1216-0074 20.6 µM -0.0502003587479555 0.477069010574795 no 1781 0.479981362838276 2531 4241466
SGTC_2556 citropten 84.59 µM -0.0502767496430861 0.477036614397587 no 1782 0.47995092571494 2481 2775 A potential DNA crosslinker.
SGTC_2218 6965428 192.983 µM -0.0521165899215795 0.476256413410948 no 1783 0.479217897042053 2509 675684
SGTC_1172 0370-0043 85 µM -0.0527599272720431 0.475983621686503 no 1784 0.478961595204837 2558 376585
SGTC_1290 0986-0249 10.2 µM -0.0537843893726963 0.47554924646727 no 1785 0.478553473496062 2500 53329
SGTC_1788 fluconazole 20 µM -0.0539661811787812 0.475472169178845 no 1786 0.478481054234917 2595 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1285 0929-0069 65.5 µM -0.0540395847927881 0.475441047290628 no 1787 0.478451813098992 2531 1206237
SGTC_2931 9014674 55.67 µM -0.0542844750818021 0.475337219043621 no 1788 0.478354259202299 2492 2996810
SGTC_2800 7887935 81.82 µM -0.05486039327794 0.475093048654159 no 1789 0.478124842959504 2564 2961002
SGTC_2924 9010168 62.78 µM -0.0554791545200764 0.474830724647338 no 1790 0.477878368325943 2570 2993929
SGTC_1169 aniline yellow 25.8 µM -0.0559123512531177 0.474647077254213 no 1791 0.477705815673026 2540 6051 A DNA damaging agent.
SGTC_2738 aclarubicin 5.55 µM -0.0564648498675827 0.474412861402129 no 1792 0.477485748286832 2567 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_425 3825-7017 13.1 µM -0.0567510131434978 0.474291554206222 no 1793 0.477371768425573 2708 3397440
SGTC_475 α-linolenic acid 10 µM -0.0568251887914742 0.474260110867987 no 1794 0.477342224300107 2627 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2349 9023730 187.07 µM -0.05692021418526 0.47421982947781 no 1795 0.477304375912735 2535 4126287
SGTC_1406 3909-7906 11.9 µM -0.0579012352127107 0.473803988846376 no 1796 0.476913649608692 2524 X1406
SGTC_1826 st055655 41.6 µM -0.0581312627561117 0.473706487610325 no 1797 0.476822036206081 2546 676168
SGTC_1356 1502-0781 85.8 µM -0.0587622387368824 0.47343904540251 no 1798 0.476570742792353 2498 567702
SGTC_601 0986-0029 62.9 µM -0.0587982325728412 0.473423789601612 no 1799 0.476556408114746 2527 24747981
SGTC_1194 1488-0194 225 µM -0.0590761058429113 0.47330601576935 no 1800 0.476445745085071 2504 1391452
SGTC_856 0433-0016 11.3 µM -0.060177382667443 0.472839273547841 no 1801 0.47600717953954 2569 3911780
SGTC_1053 3366-3204 134 µM -0.0610087720443691 0.472486939465281 no 1802 0.475676111494962 2544 3632071 YPR165W RHO1
SGTC_586 0957-0265 8.15 µM -0.0611972545093527 0.472407065560507 no 1803 0.475601058110376 2509 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1455 4262-0120 131 µM -0.0613257047772776 0.472352632355408 no 1804 0.475549909936467 2696 1529587
SGTC_2537 larixol 68.93 µM -0.0619571160336075 0.472085067544846 no 1805 0.475298491401095 2509 6708759
SGTC_2974 9094440 9.66 µM -0.0620828070738671 0.472031806611992 no 1806 0.475248444276042 2730 25236134
SGTC_2043 5101342 149 µM -0.0621112818935299 0.472019740622837 no 1807 0.475237106347408 2546 678451
SGTC_1554 st069299 38.7 µM -0.0631455410652404 0.471581498626139 no 1808 0.474825305053478 2567 24207999
SGTC_2164 5685496 200 µM -0.0648383383570535 0.470864291712935 no 1809 0.474151358031411 2528 759046
SGTC_1500 4488-1866 171 µM -0.064941738672761 0.470820485949614 no 1810 0.474110194029964 2609 2900003
SGTC_679 0422-0091 41.4 µM -0.065735725390545 0.470484123594644 no 1811 0.473794114582326 2512 627384 YHR062C RPP1
SGTC_1622 st003707 19.4 µM -0.0659719858944559 0.470384038897342 no 1812 0.47370006443467 2622 10140899
SGTC_467 ro 31-8220 72.8 µM -0.0672327316254388 0.469849993451795 no 1813 0.473198213998882 2548 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_700 3453-2283 142 µM -0.0676201415434098 0.469685899439281 no 1814 0.473044010731461 2594 565664
SGTC_71 0417-1750 47.813 µM -0.0678922378013603 0.4695706515508 no 1815 0.47293570891717 2519 6811472
SGTC_1506 4226-2149 212 µM -0.0679548897276106 0.469544115338532 no 1816 0.472910772005842 2594 991114
SGTC_792 4534-1957 155 µM -0.0680538590788136 0.469502197163028 no 1817 0.472871380138305 2593 1717904
SGTC_2418 pentamidine 31.67 µM -0.0690104693711072 0.469097045200256 no 1818 0.472490643007919 2502 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_471 1-acyl-paf 4 µM -0.0696228319805253 0.468837708800069 no 1819 0.472246931871138 2524 16759367
SGTC_3008 9078912 71.4286 µM -0.0700811335874663 0.468643626089021 no 1820 0.472064541496403 2562 16648731
SGTC_2460 5552655 174.22 µM -0.0702059933850191 0.468590751439275 no 1821 0.472014852033597 2647 5401989
SGTC_1669 st015249 58.4 µM -0.0707228204063999 0.468371895480751 no 1822 0.471809179126659 2558 722793
SGTC_991 3996-0057 64.7 µM -0.0716760597672416 0.467968261146127 no 1823 0.47142985434313 2592 715343
SGTC_3092 9117248 49.47 µM -0.0726499111713861 0.467555932970629 no 1824 0.471042354126138 2524 17141857
SGTC_46 0329-0187a 2.197 µM -0.0727962113290857 0.46749399255694 no 1825 0.470984142940461 2561 46494817
SGTC_3178 9107506 49.47 µM -0.0735875929349752 0.46715895189003 no 1826 0.470669271887368 2609 8897194
SGTC_2098 5376439 882.5 nM -0.0740182731478345 0.466976628141506 no 1827 0.470497922637277 2625 2844116
SGTC_921 1561-0023 372 µM -0.0741065515780579 0.466939257289891 no 1828 0.470462801096294 2521 24050882
SGTC_2292 7671323 168.05 µM -0.0745102663523234 0.466768356690733 no 1829 0.470302186254075 2611 937504
SGTC_502 l-744,832 89.3 µM -0.0754587404713976 0.466366872643644 no 1830 0.469924862118359 2551 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2110 5483698 200 µM -0.076022721662535 0.466128158605395 no 1831 0.469700510616573 2591 2848765 YHR062C RPP1
SGTC_2346 9031566 143.75 µM -0.0776164892829681 0.465453637183976 no 1832 0.469066562700034 2631 4771086
SGTC_359 0081-0058 15.9 µM -0.0788880593949256 0.464915548706223 no 1833 0.468560830431798 2701 3494159
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.079113247204402 0.464820262966137 no 1834 0.468471273397603 2563 6708514
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0803400113635017 0.464301206802139 no 1835 0.467983418288768 2627 521171
SGTC_489 paxilline 115 µM -0.0804415025156308 0.464258267591112 no 1836 0.467943059799918 2599 105008 A toxic potassium channel blocker.
SGTC_254 nsc-64875 3.808 µM -0.0805371769584014 0.464217789713815 no 1837 0.467905014657744 2685 56993
SGTC_883 0850-0245 24.6 µM -0.0805511705658787 0.464211869339046 no 1838 0.467899450095043 2726 6823229 YPR165W RHO1
SGTC_131 0141-0277 33.849 µM -0.0811272098015497 0.463968167225898 no 1839 0.467670393356006 2633 1547771
SGTC_1427 4048-4900 550 nM -0.081325510232135 0.463884276352068 no 1840 0.467591543474448 2619 24132586
SGTC_943 3253-1379 105 µM -0.0822232473708835 0.463504509358119 no 1841 0.467234593652964 2627 668464
SGTC_2476 5806916 10.51 µM -0.0825948194362403 0.463347334075294 no 1842 0.467086860346211 2588 2870194
SGTC_1769 st044406 64.4 µM -0.0830333875258614 0.463161826783705 no 1843 0.466912495931036 2560 670903
SGTC_677 0929-0063 136 µM -0.0834721086004705 0.462976262796552 no 1844 0.466738077045439 2557 1539583
SGTC_1714 st033236 13.627 µM -0.0837348656730811 0.462865129409787 no 1845 0.466633617839704 2636 2916566
SGTC_2281 7943571 200 µM -0.0847175429709526 0.462449530747476 no 1846 0.466242974416254 2595 1244024
SGTC_2662 daunorubicin 22.37 µM -0.0852164585836007 0.46223854259 no 1847 0.466044653059407 2534 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_381 3461-2219 42.7 µM -0.0855305116594741 0.462105737038479 no 1848 0.465919819771574 2596 2883159
SGTC_821 1114-0266 29.2 µM -0.0859508164324763 0.461928006792728 no 1849 0.465752757633601 2625 3123235
SGTC_495 decylubiquinone 155 µM -0.086226095005984 0.46181160650196 no 1850 0.465643343570194 2604 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1698 5-fluorocytosine 1.055 µM -0.0865971365778264 0.461654718441047 no 1851 0.465495871015699 2565 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1267 0828-0272 9.49 µM -0.0874874887059854 0.461278273907114 no 1852 0.465142014932437 2630 745334
SGTC_3280 9140961 49.47 µM -0.0886046196027296 0.460805995491435 no 1853 0.464698068308184 2556 4901226
SGTC_2003 4023581 200 µM -0.0888767270616017 0.460690967650384 no 1854 0.464589939728907 2649 16641307
SGTC_2005 4024620 188 µM -0.0890115301211272 0.46063398364264 no 1855 0.464536373391783 2568 236743
SGTC_831 k061-1017 217 µM -0.089970785971406 0.460228510006289 no 1856 0.464155215035147 2644 1240153
SGTC_707 0865-0008 204 µM -0.0902723666693739 0.460101041568225 no 1857 0.464035389339676 2573 723043
SGTC_1175 0741-0056 27.6 µM -0.09231479927465 0.459237879734563 no 1858 0.463223965228966 2654 765927
SGTC_3036 9090181 49.47 µM -0.0923813984170027 0.459209737177212 no 1859 0.463197509067448 2564 25236586
SGTC_1880 MG-132 525 µM -0.0936119836043671 0.45868977019991 no 1860 0.462708694940225 2608 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1736 st036774 51 µM -0.0945394927079875 0.458297910544673 no 1861 0.462340306134151 2773 1272247
SGTC_2919 7978188 46.38 µM -0.0950193742806338 0.458095183159724 no 1862 0.462149719047746 2599 2980291
SGTC_1423 4048-0112 5.59 µM -0.0953616739605935 0.457950584308654 no 1863 0.462013778525374 2631 X1423
SGTC_2078 5212016 200 µM -0.0962821100422862 0.457561788930491 no 1864 0.461648259593915 2550 1899708
SGTC_3004 9076122 71.4286 µM -0.097872874270082 0.456889940580421 no 1865 0.461016619873628 2648 44782551
SGTC_2065 5221596 34.26 µM -0.10077522538227 0.45566447130976 no 1866 0.459864446991039 2694 788581
SGTC_3086 9117350 49.47 µM -0.101444745957042 0.455381836867316 no 1867 0.45959870876013 2587 2679265
SGTC_2095 5432005 200 µM -0.10194774090681 0.455169515152186 no 1868 0.459399077787921 2623 783734
SGTC_1623 st003709 20.3 µM -0.102454619975503 0.454955566846253 no 1869 0.459197915624211 2580 16192618
SGTC_678 1218-2179 85.9 µM -0.103478620362065 0.454523387011387 no 1870 0.45879155843702 2595 6820081 YOR116C RPO31
SGTC_481 bay k-8644 50 µM -0.103984133350022 0.454310054836543 no 1871 0.458590970028782 2594 2303 A calcium channel antagonist.
SGTC_2748 diazoxide 86.69 µM -0.104165143587771 0.454233669678726 no 1872 0.458519147421433 2671 3019 A potassium channel activatior.
SGTC_2642 cholecalciferol 100 µM -0.105534465287942 0.453655879748591 no 1873 0.457975861665445 2624 9821465 A vitamin D precursor, similar to steriods.
SGTC_2802 7925815 54.55 µM -0.105716170522015 0.453579215953933 no 1874 0.457903775013642 2618 1262923
SGTC_1349 flufenamic acid 69 µM -0.105797718544339 0.453544810347979 no 1875 0.457871423484822 2594 3371 A non-steroidal anti-inflammatory.
SGTC_2757 clomiphene 4.22 µM -0.107236025494948 0.452938037449242 no 1876 0.457300867993937 2688 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2517 totarol 10 µM -0.107566261507075 0.452798737539003 no 1877 0.457169880540073 2647 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3181 9108277 49.47 µM -0.107760415014298 0.452716842560677 no 1878 0.457092872110675 2613 17097298
SGTC_3235 9132602 49.47 µM -0.108593784475775 0.452365345792756 no 1879 0.456762345434458 2686 4912240
SGTC_1884 5633444 25 µM -0.108662799806507 0.452336238325883 no 1880 0.456734974269701 2714 5724239
SGTC_2773 thioridazine 9.09 µM -0.109077288319016 0.452161431682003 no 1881 0.45657059434271 2577 5452 An antipsychotic.
SGTC_1316 1272-0050 65.9 µM -0.110991231956001 0.451354364696852 no 1882 0.455811649828719 2612 7340392
SGTC_709 3807-1509 243 µM -0.11141657206463 0.451175035524933 no 1883 0.455643009635698 2579 1886677 YPL242C IQG1
SGTC_1741 st038134 10.228 µM -0.112150068865242 0.450865806731676 no 1884 0.455352209292729 2732 1272587
SGTC_3046 9092212 49.47 µM -0.115223238007334 0.449570541342862 no 1885 0.454134090039229 2580 25236637
SGTC_2472 5377652 49.4 µM -0.117616455960501 0.448562229990172 no 1886 0.453185782740764 2657 1610903
SGTC_1668 st014914 51.6 µM -0.118490950647978 0.448193870131066 no 1887 0.452839332460699 2617 2839556
SGTC_2192 5915882 198.485 µM -0.118816868182515 0.448056596614805 no 1888 0.452710222238507 2612 2876149
SGTC_50 0929-0078 56.389 µM -0.118927240537125 0.448010110186912 no 1889 0.452666500043197 2685 1377751
SGTC_2113 5491891 107.031 µM -0.119348132927434 0.447832846052371 no 1890 0.452499775707954 2625 789979
SGTC_125 0133-0007 11.75 µM -0.119538515049825 0.447752667641959 no 1891 0.45242436409098 2716 26541
SGTC_2947 9072639 7.68 µM -0.120067089865527 0.447530072392459 no 1892 0.452215001118255 2676 16488146
SGTC_3290 9121031 71.43 µM -0.120720509247512 0.447254925015837 no 1893 0.451956206885509 2652 17014854
SGTC_2008 4012253 172 µM -0.120962167628502 0.447153171877403 no 1894 0.451860500479956 2634 603940
SGTC_530 4358-1714 28 µM -0.121365231287225 0.4469834648677 no 1895 0.451700877341762 2726 1564641
SGTC_139 0099-0334 718.624 µM -0.121706531818801 0.446839770360563 no 1896 0.451565720027591 2622 97690
SGTC_1190 1486-1332 13 µM -0.122349228768573 0.446569200754295 no 1897 0.451311222949623 2601 4150046
SGTC_65 0798-0905 34.986 µM -0.122354326293676 0.446567054841559 no 1898 0.451309204496099 2936 3602145
SGTC_1139 k015-0024 46.9 µM -0.125633482294922 0.445186950663107 no 1899 0.450011028948152 2610 2766652
SGTC_1205 4161-2785 76 µM -0.126600315014423 0.444780164079992 no 1900 0.449628373801286 2782 3498106
SGTC_1273 0849-0096 14.1 µM -0.126670762024518 0.444750526371719 no 1901 0.449600493957463 2665 5286025
SGTC_122 0236-0016 402.397 µM -0.12667546938813 0.444748545951346 no 1902 0.449598630997806 2643 6808838
SGTC_862 0452-0056 10.2 µM -0.126889870576288 0.444658347353867 no 1903 0.449513781971752 2638 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1339 1486-1321 22.7 µM -0.126956901207207 0.444630148149724 no 1904 0.449487255149369 2654 3469382
SGTC_2804 7954240 19.48 µM -0.128017659673039 0.444183933678463 no 1905 0.449067498816798 2740 828705
SGTC_1282 0886-0010 32.4 µM -0.128680429512866 0.443905171403988 no 1906 0.448805260816237 2702 2836211 YNL267W PIK1
SGTC_479 n-linoleoylglycine 10 µM -0.129319841937064 0.443636259603902 no 1907 0.448552285833849 2646 6433346 An anti-infammatory.
SGTC_2060 5238662 140 µM -0.129460445613827 0.443577130685805 no 1908 0.448496660669733 2725 790130
SGTC_1626 st003712 1.76 µM -0.130087612487461 0.443313399708171 no 1909 0.448248555320132 2767 24207035
SGTC_3313 9133968 57.047 µM -0.131475567018165 0.442729838092083 no 1910 0.447699556738771 2615 1494643
SGTC_1725 st036284 20.55 µM -0.13149128616525 0.442723229729517 no 1911 0.447693339679246 2877 707914
SGTC_536 3852-0578 10.6 µM -0.131811878864363 0.442588455362298 no 1912 0.447566545281357 2806 2869208
SGTC_897 1000-0139 31.4 µM -0.131870713388416 0.442563722563914 no 1913 0.447543276811262 2725 6151020
SGTC_550 4123-0385 25.7 µM -0.134764361750872 0.44134757168334 no 1914 0.446399091967854 2652 5731123
SGTC_692 k241-0027 77.8 µM -0.135301074979041 0.441122060734932 no 1915 0.446186917592124 2774 3600480
SGTC_999 SEC7.066 22.7 µM -0.135742341277859 0.440936668045263 no 1916 0.446012486995135 2679 740511 YDR170C SEC7
SGTC_736 0958-0254 92.6 µM -0.135800339801949 0.440912301629544 no 1917 0.445989561213756 2748 6812352
SGTC_1370 2001-0092 44.6 µM -0.136239812066146 0.440727677243407 no 1918 0.445815851544889 2744 790957
SGTC_1614 st002383 48.6 µM -0.136253458565639 0.440721944490163 no 1919 0.445810457675904 2657 1947235
SGTC_1546 5-methoxyflavanone 78.7 µM -0.136749015532173 0.440513774562055 no 1920 0.445614592317191 2712 147795
SGTC_1995 st072814 61.1 µM -0.137317407704435 0.44027502880053 no 1921 0.445389955707701 2659 5769371
SGTC_2459 5811157 9.22 µM -0.138329154302022 0.439850111537673 no 1922 0.444990142595907 2627 2870684 YBR192W RIM2
SGTC_2990 9074105 71.4286 µM -0.140882733638174 0.43877795854081 no 1923 0.443981291326256 2637 6502001
SGTC_1776 st049249 45.9 µM -0.141283443809259 0.438609755805774 no 1924 0.443823014171254 2687 1822314
SGTC_2515 chrysin 20.77 µM -0.141810131442368 0.43838868944055 no 1925 0.443614990608619 2761 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_186 3455-3465 67.277 µM -0.142187701057308 0.438230224139906 no 1926 0.443465873109928 2651 755278
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.142481036023437 0.438107118807177 no 1927 0.443350028802506 2721 279621
SGTC_1235 benzylparaben 21.5 µM -0.143388403855154 0.43772635724074 no 1928 0.442991720361808 2743 7180
SGTC_2608 thymoquinone 42.66 µM -0.144125499232225 0.437417090055508 no 1929 0.442700684728629 2629 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_712 r015-0009 80.6 µM -0.144742110790672 0.437158404293877 no 1930 0.442457244815194 2768 6813872 YLR060W FRS1
SGTC_1152 3909-8331 15.9 µM -0.144824466723286 0.437123855712388 no 1931 0.442424732112612 2663 16001939
SGTC_976 1348-1067 47.6 µM -0.145206930103398 0.436963417368896 no 1932 0.44227374724839 2668 5310671 YGL099W LSG1
SGTC_2077 5212015 200 µM -0.146059056073871 0.436605999080459 no 1933 0.441937384118059 2622 780900
SGTC_3230 9131665 49.47 µM -0.147144246243304 0.436150898591994 no 1934 0.441509083246861 2647 15943720
SGTC_593 1203-0218 61.7 µM -0.147720630391241 0.435909212423759 no 1935 0.441281624781194 2782 3666956
SGTC_376 3970-0862 59.1 µM -0.148710154910189 0.435494346411305 no 1936 0.440891173941984 2768 3135186
SGTC_2702 st077768 96.8 µM -0.150336151681667 0.434812788712591 no 1937 0.440249706084883 2752 6484119
SGTC_2122 5258151 111.688 µM -0.151925473687906 0.434146790853255 no 1938 0.439622858204746 2714 2173356
SGTC_1920 st075728 45.7 µM -0.152865287380016 0.433753054180134 no 1939 0.439252255389387 2816 3400306
SGTC_2163 5671233 125 µM -0.154550845914211 0.433047051238602 no 1940 0.438587711763302 2756 701023
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.15496834746677 0.432872211966389 no 1941 0.438423135436336 2803 6728940
SGTC_667 1498-1044 59 µM -0.155883272167468 0.432489110240577 no 1942 0.438062515495188 2711 6739982
SGTC_380 3970-0968 6 µM -0.156206877521286 0.432353623804294 no 1943 0.437934977903303 2698 2891601
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.156604897442669 0.432186992536772 no 1944 0.437778121286814 2739 4213774
SGTC_1094 duloxetine 25.4 µM -0.156637344176284 0.432173409224537 no 1945 0.437765334707138 2664 60834 A selective serotonin reuptake inhibitor.
SGTC_3265 9137266 49.47 µM -0.156773483600688 0.432116417480179 no 1946 0.437711685713408 2641 17224265
SGTC_1650 st011916 45.8 µM -0.157882485441338 0.431652211232585 no 1947 0.437274699775206 2734 242528
SGTC_1231 0242-0792 125 µM -0.158064680249395 0.431575957095911 no 1948 0.43720291588162 2680 3707635
SGTC_2074 5212007 75.395 µM -0.161096920224404 0.430307247777523 no 1949 0.436008532934685 2701 758611
SGTC_305 1682-2595 20.8 µM -0.162757874497066 0.429612597489788 no 1950 0.435354538597238 2741 226033
SGTC_2158 5657123 3.6195 µM -0.162992035682731 0.42951468322736 no 1951 0.435262352710653 2670 2858827
SGTC_1260 0700-1617 7.75 µM -0.16415269762538 0.429029417736856 no 1952 0.434805468854659 2785 2853078
SGTC_336 4111-0029 111 µM -0.164528540866147 0.428872302983338 no 1953 0.434657540260549 2753 3131175
SGTC_1068 loratadine 26.9 µM -0.165148663550823 0.428613096090679 no 1954 0.434413485432348 2739 3957 A H1 histamine antagonist.
SGTC_810 3825-7150 143 µM -0.165756616982058 0.428359005748458 no 1955 0.434174244184176 2851 22330411 YGL099W LSG1
SGTC_2992 9074591 71.4286 µM -0.166328840327925 0.428119875700118 no 1956 0.433949085427274 2722 17741321
SGTC_3344 9148862 3.898 µM -0.167005305587053 0.427837217387629 no 1957 0.433682937150726 2842 4905352
SGTC_619 1652-1634 108 µM -0.16781836020573 0.427497534766168 no 1958 0.433363088995562 2756 5400454
SGTC_328 k915-0120 63.5 µM -0.168016530604255 0.427414750136177 no 1959 0.433285137203107 2833 6624543
SGTC_571 k831-0106 44.2 µM -0.168390664849584 0.427258466260477 no 1960 0.43313797580751 2735 4783639
SGTC_210 3551-0445 56.827 µM -0.169559119775788 0.426770451254015 no 1961 0.43267843730357 2850 2865180 YOR207C RET1
SGTC_1239 0337-0584 35.4 µM -0.169711293953714 0.426706902664129 no 1962 0.432618595816366 2861 914301 YML130C ERO1
SGTC_591 4299-0174 154 µM -0.170164900905012 0.426517485748194 no 1963 0.432440227062732 2735 5509088
SGTC_119 0121-0043 24.815 µM -0.170412358522555 0.42641415968778 no 1964 0.432342926800847 2689 1092378
SGTC_199 4063-0024 41.6 µM -0.171374327837108 0.426012536927631 no 1965 0.431964719782006 2824 306215
SGTC_431 k089-0097 107 µM -0.171964011411857 0.425766381592383 no 1966 0.431732911101171 2733 5499420
SGTC_2987 9018338 71.43 µM -0.173403256640648 0.425165710019995 no 1967 0.431167232727206 2677 5055682
SGTC_20 0481-0013 4.944 µM -0.173632410683871 0.425070088161991 no 1968 0.431077179428705 2717 182045
SGTC_3312 9133330 71.43 µM -0.1744062206013 0.424747223818023 no 1969 0.430773112955243 2872 17617324
SGTC_848 0368-0089 85.6 µM -0.175033686984282 0.424485456880949 no 1970 0.430526581888637 2820 762535
SGTC_2953 9074162 66.49 µM -0.176487298567647 0.423879166144894 no 1971 0.429955563169694 2807 16451992
SGTC_1421 4029-0249 71.4 µM -0.177344989942592 0.423521513766978 no 1972 0.429618706978143 2870 2894095
SGTC_363 0455-0021 3.06 µM -0.177691952508025 0.423376850250636 no 1973 0.429482452819987 2717 4597466
SGTC_2891 9063876 19.48 µM -0.178749171419659 0.422936114283721 no 1974 0.429067328845909 2810 6472478
SGTC_1084 voriconazole 435 nM -0.178825374242334 0.422904350386878 no 1975 0.429037410330683 2750 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2401 5128683 200 µM -0.179156781377268 0.422766214590358 no 1976 0.428907299036431 2768 708373
SGTC_394 menadione 8.33 µM -0.179578609425076 0.422590403648881 no 1977 0.428741699434874 2716 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2058 5236698 133 µM -0.179715058807834 0.422533537105714 no 1978 0.428688135354717 2755 766665
SGTC_1063 disulfiram 1.84 µM -0.181019280699168 0.421990072195563 no 1979 0.428176221104821 2709 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1906 st060206 94.7 µM -0.181286386563002 0.421878788362677 no 1980 0.428071395468545 2861 5133468
SGTC_96 0929-0093 37.281 µM -0.18247680631552 0.421382901904282 no 1981 0.42760427732521 2712 6991579
SGTC_72 0744-0168 198.391 µM -0.182625188623296 0.421321099843409 no 1982 0.427546059525999 2739 677577
SGTC_3157 9099274 49.47 µM -0.182962232474167 0.421180726399179 no 1983 0.427413826232834 2778 17217662
SGTC_161 4065-0411 162.148 µM -0.18392293456809 0.420780664174508 no 1984 0.4270369562692 2858 1906281 YLR208W SEC13
SGTC_1384 3089-0840 101 µM -0.183961228151145 0.420764719387771 no 1985 0.427021935611104 2812 1069836
SGTC_1932 st074806 40.9 µM -0.185380224265136 0.420173965776862 no 1986 0.426465409168331 2978 17251235
SGTC_2106 5357045 167.29 µM -0.187055398329443 0.419476792173978 no 1987 0.425808598910996 2849 668842
SGTC_501 nsc-95397 161 µM -0.187466784345648 0.419305620189446 no 1988 0.42564733211883 2913 262093
SGTC_3207 9114163 49.47 µM -0.187873147575872 0.419136553107908 no 1989 0.42548804651085 2992 849233
SGTC_3014 9081533 49.47 µM -0.187878483246828 0.419134333305716 no 1990 0.425485955123922 2873 21367265
SGTC_1915 st067105 30.6 µM -0.189603362808881 0.4184168659968 no 1991 0.424809975936887 2702 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_871 0574-0004 149 µM -0.191457650225353 0.417645873905027 no 1992 0.424083528484228 2757 9551173
SGTC_609 0986-0026 86.3 µM -0.191547513434685 0.417608517797893 no 1993 0.424048329632354 2757 2848610
SGTC_1459 k035-0031 35.7 µM -0.191613294016756 0.417581173302462 no 1994 0.424022564177629 2730 3877128 YMR208W ERG12
SGTC_1944 st076371 56.9 µM -0.192729935043714 0.417117054896109 no 1995 0.42358523908963 2765 24208455
SGTC_2656 pseudo-anisatin 100 µM -0.193785855184887 0.416678280606086 no 1996 0.423171781496794 2758 6708809 A neurotoxin.
SGTC_1548 st061468 90.8 µM -0.19403554188463 0.416574541601008 no 1997 0.423074026167627 2861 390799
SGTC_2695 st077686 51.995 µM -0.194736789294656 0.416283220739198 no 1998 0.422799504767073 2807 2876092
SGTC_2762 leflunomide 42.06 µM -0.195633649347522 0.415910703090374 no 1999 0.422448460394645 2760 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1534 6-azauridine 81.6 µM -0.195863260375998 0.415815344534507 no 2000 0.422358597112091 2726 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3225 9130819 49.47 µM -0.196201516032428 0.415674874377239 no 2001 0.422226220748725 2843 4547121
SGTC_2967 9089538 49.85 µM -0.196877327421841 0.415394257010434 no 2002 0.421961768261241 2994 728216
SGTC_1281 0884-0031 11.8 µM -0.196895866698123 0.415386559548581 no 2003 0.421954514132236 2752 1548255
SGTC_2526 patulin 37.61 µM -0.198389697796974 0.414766431530837 no 2004 0.421370088611394 2901 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_914 3820-6779 408 µM -0.198651021842235 0.414657970923486 no 2005 0.421267869619887 2728 2893481
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.199557579346947 0.414281761436691 no 2006 0.420913303573633 2751 229346 A bile salt which induces apoptosis.
SGTC_1994 st072947 40.9 µM -0.200433261507931 0.413918439467975 no 2007 0.420570874159207 2864 5286565 YDL195W SEC31
SGTC_684 1140-0066 328 µM -0.200896614884394 0.413726223173241 no 2008 0.420389707342773 2827 6813534
SGTC_3296 9122258 64.045 µM -0.201097586636309 0.413642859005052 no 2009 0.420311134517252 2867 4730474
SGTC_179 1273-0063 6.77 µM -0.202866588937123 0.41290923561402 no 2010 0.419619654706327 2772 3108139
SGTC_758 0868-0029 16 µM -0.20368479282593 0.412570020756111 no 2011 0.419299913321968 2889 762687
SGTC_754 3474-0146 171 µM -0.203841537886088 0.412505044088004 no 2012 0.419238665859657 2748 24762078
SGTC_1966 st070145 16.1 µM -0.20474522414432 0.412130479275275 no 2013 0.418885592525057 2738 3748532
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.205125581784594 0.411972850475996 no 2014 0.418737005001321 2781 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_718 1130-0073 349 µM -0.205551735490877 0.411796259623269 no 2015 0.418570540917852 2936 6740020
SGTC_1431 4049-0260 9.09 µM -0.205971324150056 0.411622406665907 no 2016 0.418406655517594 2736 3854841
SGTC_1520 flindersine 88 µM -0.207084913257847 0.411161084794563 no 2017 0.417971772098157 3053 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_327 1273-0057 3.96 µM -0.207372456106632 0.411041985555472 no 2018 0.417859495945196 2833 3108138
SGTC_2299 7976368 114.88 µM -0.208025549774664 0.410771506927214 no 2019 0.41760450894264 2922 2979718
SGTC_1434 4073-0095 163 µM -0.208175539959496 0.41070939450414 no 2020 0.417545953244571 2794 24133745
SGTC_2031 5180455 200 µM -0.209440038137093 0.410185842423819 no 2021 0.417052369923523 2780 29949
SGTC_1306 1185-0270 9.02 µM -0.210203881747388 0.409869658544462 no 2022 0.416754275025437 2887 1548076
SGTC_1201 1889-3372 45.9 µM -0.212306953447867 0.408999420658671 no 2023 0.415933785508103 2814 5392199
SGTC_708 3448-5400 146 µM -0.21429686137311 0.408176421955616 no 2024 0.41515778272598 2831 3462195
SGTC_168 3970-0862 530.542 µM -0.214802366757771 0.407967416193696 no 2025 0.414960703782116 2865 3135186
SGTC_3342 9147791 14.508 µM -0.214967697770814 0.407899064274561 no 2026 0.414896251619671 2773 1838168
SGTC_1376 2910-0861 41.3 µM -0.215851781062525 0.407533610051981 no 2027 0.414551642069529 2780 1112859
SGTC_762 1165-0429 115 µM -0.215855025222703 0.407532269158846 no 2028 0.41455037763927 2944 5967793
SGTC_880 0833-0487 87.2 µM -0.216388212342013 0.407311904221753 no 2029 0.414342576905638 2798 76075
SGTC_2303 7774051 200 µM -0.217114935825484 0.407011598423833 no 2030 0.414059387238315 2962 2953184
SGTC_2828 7998861 71.43 µM -0.218783528757042 0.406322288617922 no 2031 0.413409339101571 2886 2988188
SGTC_7 0192-1582 4.227 µM -0.220143069507546 0.405760865339332 no 2032 0.412879866424726 2819 252616
SGTC_1850 st056238 17 µM -0.221294900593913 0.405285367490571 no 2033 0.412431410150619 2751 5393177
SGTC_614 0462-0418 107 µM -0.223534382752233 0.404361267164269 no 2034 0.41155981322956 2827 5188303
SGTC_3016 9080866 49.47 µM -0.224351536949363 0.40402420903927 no 2035 0.411241888699243 2836 17066299
SGTC_3172 9105863 49.47 µM -0.225219845308237 0.40366612902406 no 2036 0.410904125844102 2838 2348785
SGTC_1488 4013-0813 75.9 µM -0.225871607711894 0.403397403002749 no 2037 0.410650640477338 2803 2910057
SGTC_3145 9085516 49.47 µM -0.226397366199114 0.403180662470003 no 2038 0.41044618811317 2890 25236195
SGTC_15 0266-0086 27.098 µM -0.226647421394099 0.403077589266703 no 2039 0.410348957370866 2877 1712902 YIL048W NEO1
SGTC_2066 5222451 176 µM -0.229515365439938 0.401895900796495 no 2040 0.409234189725235 2812 2281147
SGTC_346 4513-0042 7.16 µM -0.2297600501569 0.401795123888951 no 2041 0.409139114802771 2816 2827372
SGTC_3051 9093778 49.47 µM -0.230630983073987 0.40143647071414 no 2042 0.408800747701498 2797 17217378
SGTC_2540 epiandrosterone 100 µM -0.23490668288711 0.399676932468831 no 2043 0.407140581249719 2846 441302 A steroid.
SGTC_2690 usnic acid 100 µM -0.235085872716127 0.399603236367227 no 2044 0.407071041704865 3050 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1992 st073643 23.3 µM -0.237472625118442 0.398621969454887 no 2045 0.406145076929506 2785 3161292
SGTC_217 ketoconazole 989 nM -0.238169112250663 0.398335742749452 no 2046 0.405874966362374 2904 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_851 0394-0702 453 µM -0.239371466898582 0.397841754700983 no 2047 0.405408776535884 2954 762646
SGTC_760 0568-0725 82.9 µM -0.239697857748323 0.397707685070642 no 2048 0.405282247903666 2978 3916171
SGTC_984 1492-0255 2.91 µM -0.240046298862417 0.39756457131693 no 2049 0.405147182193583 2948 1585198
SGTC_556 4058-0063 51.5 µM -0.240294565716692 0.397462610125558 no 2050 0.405050953773695 2870 6615692
SGTC_3107 9121808 49.47 µM -0.241001516432431 0.397172309576677 no 2051 0.404776970608992 2817 662681
SGTC_3058 9093861 49.47 µM -0.241504269034046 0.396965895099251 no 2052 0.40458215409121 3011 17217477
SGTC_3000 9075062 71.4286 µM -0.241907481289629 0.39680036962417 no 2053 0.404425926524155 2882 17057871
SGTC_1917 st066507 28.5 µM -0.241909534697402 0.396799526712984 no 2054 0.404425130955121 2834 3156428
SGTC_1627 st003713 25.6 µM -0.241914576083557 0.396797457257203 no 2055 0.404423177730184 2905 16195070 YER133W GLC7
SGTC_1090 efavirenz 20.7 µM -0.242514777966482 0.396551099128748 no 2056 0.404190653706364 2882 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_666 0272-0154 136 µM -0.24332953512038 0.396216740995583 no 2057 0.403875063059698 2880 6870312
SGTC_774 k060-0086 136 µM -0.243921524965112 0.395973849450067 no 2058 0.403645799046812 2844 5911235
SGTC_2816 7982706 58.44 µM -0.243966985153427 0.39595519894824 no 2059 0.40362819473207 2960 2981853
SGTC_1287 0971-0001 34.6 µM -0.244115102104092 0.39589443412432 no 2060 0.403570838264014 2841 4665869
SGTC_834 0312-0008 75.7 µM -0.244842857664916 0.395595909946158 no 2061 0.403289054020563 2828 6385573 YIL048W NEO1
SGTC_1628 st004252 77.7 µM -0.245872631282724 0.395173603115261 no 2062 0.402890415324735 2997 692968
SGTC_2729 fluphenazine 10.66 µM -0.245966747035171 0.395135012681311 no 2063 0.402853986926075 2835 3372 An atypical antipsychotic.
SGTC_3105 9121040 49.47 µM -0.246178586558026 0.395048155543149 no 2064 0.402771995506151 2761 41448907
SGTC_2955 9076254 12.21 µM -0.247441243795416 0.394530556905832 no 2065 0.402283379198201 2960 16459619
SGTC_3166 9102297 49.47 µM -0.248005711398532 0.394299225948215 no 2066 0.402064993887001 2891 25237072
SGTC_3049 9092223 49.47 µM -0.249395223346255 0.393729933069451 no 2067 0.401527539831715 2947 8623917
SGTC_1304 1165-0502 251 µM -0.250609961978865 0.39323243201841 no 2068 0.401057839463755 2873 767425
SGTC_1846 st056244 14.8 µM -0.251351362026053 0.392928874274682 no 2069 0.400771234122068 2918 5393182
SGTC_2017 5132927 60.65 µM -0.252280880754298 0.392548385490299 no 2070 0.40041198261885 2867 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1787 fluconazole 80 µM -0.253919470173807 0.391877896270353 no 2071 0.399778886312482 2904 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_756 0508-1999 28.3 µM -0.254194063570078 0.391765567615725 no 2072 0.399672818302925 2870 6753853
SGTC_540 1187-0821 17.3 µM -0.254971248925561 0.391447691259313 no 2073 0.399372652753614 2850 847520
SGTC_1409 3909-8004 61.9 µM -0.255026322741535 0.391425168281377 no 2074 0.399351384326662 2887 2119279
SGTC_373 0844-0104 25.9 µM -0.255237273851255 0.391338901121334 no 2075 0.399269921911766 2988 5375804
SGTC_1288 0973-0013 65.5 µM -0.256724287891593 0.390730947721303 no 2076 0.398695810376885 2948 4315430
SGTC_1021 4476-0760 85.3 µM -0.257691987813821 0.390335454922499 no 2077 0.398322315062706 2878 746768
SGTC_1562 morin hydrate 59.1 µM -0.257692542181673 0.390335228388365 no 2078 0.398322101124488 3041 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2774 tamoxifen 10.92 µM -0.258420181915313 0.390037921415776 no 2079 0.398041321261228 2822 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_633 0437-0093 97.7 µM -0.259466750664807 0.38961041576183 no 2080 0.397637566446589 2868 2831118
SGTC_3328 9140624 29.0385 µM -0.259926654729201 0.389422594924128 no 2081 0.397460175119095 3037 4904392
SGTC_292 k038-0015 474 µM -0.260200013854892 0.389310969659366 no 2082 0.397354746787111 2979 46368540
SGTC_1953 st076800 12.1 µM -0.260320051719671 0.389261955492869 no 2083 0.397308453310523 2899 297591
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.261230833472874 0.388890120220992 no 2084 0.396957250867122 2844 803109
SGTC_2000 st075254 36.4 µM -0.261503495958643 0.388778822956202 no 2085 0.396852126953828 2879 17234175
SGTC_1252 0493-0875 34.8 µM -0.261653191445982 0.388717723094626 no 2086 0.396794415653692 2840 3960963
SGTC_474 dl-dihydrosphingosine 5 µM -0.261778167986973 0.388666714651598 no 2087 0.396746235847948 3008 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_382 3229-0966 23.2 µM -0.263293168819133 0.388048528854889 no 2088 0.396162312245594 3045 5722370
SGTC_2606 farnesol 9.78 µM -0.263561652058761 0.387939005628636 no 2089 0.396058855567755 3055 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_797 k781-0471 270 µM -0.263566457558654 0.387937045386875 no 2090 0.396057003894793 2889 23738129
SGTC_1958 st076513 41.9 µM -0.267441387666299 0.38635733184452 no 2091 0.394564668391422 2856 732122 YGL099W LSG1
SGTC_2603 homopterocarpin 100 µM -0.269564754327673 0.385492483943897 no 2092 0.39374755939315 3011 101795 A weak amylase inhibitor.
SGTC_1109 tnp00067 928.257 nM -0.270148177992084 0.385254954779934 no 2093 0.393523129401573 2910 676295
SGTC_2318 6029776 164 µM -0.272254941416998 0.384397587520726 no 2094 0.392712999765468 3080 818325
SGTC_1137 ixabepilone 100 µM -0.272966061982421 0.384108317678208 no 2095 0.392439651906835 2869 154225 A novel microtubule stabilizer.
SGTC_1046 2001-0062 216 µM -0.273642564391495 0.38383318972451 no 2096 0.392179660173918 2874 739778
SGTC_795 0685-0265 78 µM -0.274287734052116 0.383570859077685 no 2097 0.391931754997179 2886 302754
SGTC_1476 4112-3294 3.34 µM -0.274914812351474 0.383315935642967 no 2098 0.391690843427775 3020 704369
SGTC_3099 9120367 49.47 µM -0.275087755310627 0.38324563877005 no 2099 0.391624409330568 2879 24824940
SGTC_1227 3909-8010 46.6 µM -0.275456623934812 0.383095715990499 no 2100 0.391482723149287 2901 15982272
SGTC_1019 4262-0212 3.4 µM -0.275802080936357 0.382955324496013 no 2101 0.391350042663573 2976 4677213
SGTC_1800 st050079 29.0735 µM -0.276066483880133 0.382847883232781 no 2102 0.391248501340275 2993 3645560
SGTC_1024 4507-0395 26 µM -0.276403250322045 0.382711049806562 no 2103 0.391119180267167 3055 4201836
SGTC_2611 pyromycin 23.93 µM -0.27677026005534 0.382561944732766 no 2104 0.39097825922992 2920 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2770 toltrazuril 17.5 µM -0.27778743304641 0.382148788820741 no 2105 0.390587769320579 2905 68591 Kills coccidiodes.
SGTC_1743 st037606 46.3785 µM -0.278356025701512 0.381917895953804 no 2106 0.390369536212927 2915 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2369 9071472 200 µM -0.28119381760693 0.380766160960602 no 2107 0.389280873138948 3039 17296037
SGTC_3079 9117512 49.47 µM -0.281226913761006 0.380752734895408 no 2108 0.389268181557234 2897 7185044
SGTC_719 2810-4230 27.3 µM -0.284279860152691 0.379514870444035 no 2109 0.388097959498085 2886 721079
SGTC_1828 st055811 49 µM -0.284406450267743 0.379463569076724 no 2110 0.388049458208948 3060 5877589
SGTC_3059 1327-0034 3 µM -0.284953124837838 0.379242050464492 no 2111 0.387840027308498 2910 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1353 1498-1206 8.11 µM -0.285470039207157 0.379032627479906 no 2112 0.387642027539473 2926 6756808
SGTC_2850 9015429 58.44 µM -0.285702579687345 0.378938427470537 no 2113 0.387552964358819 2965 6457570
SGTC_270 tamoxifen 5.46 µM -0.285801474789722 0.378898368153079 no 2114 0.387515089252447 3109 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3316 9136639 10.545 µM -0.285885434324268 0.378864359788653 no 2115 0.387482935049307 3009 4903665
SGTC_1044 1222-0021 1.78 µM -0.287733773216472 0.37811591591528 no 2116 0.386775267740553 3026 4306703
SGTC_582 0987-0078 156 µM -0.287803703592824 0.378087608117299 no 2117 0.386748501105084 2999 1625765
SGTC_2887 9044784 58.44 µM -0.28794848807981 0.378029001475438 no 2118 0.386693084932067 2922 6465546
SGTC_2938 9059746 27.26 µM -0.288415715593056 0.377839893764373 no 2119 0.386514269652375 3038 6471769
SGTC_2670 beta-carotene 100 µM -0.289060187729843 0.377579095330884 no 2120 0.386267659628624 3028 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_430 0958-0115 16.4 µM -0.290273758249985 0.377088151513397 no 2121 0.385803406439579 2947 6833180
SGTC_893 0958-0369 48.9 µM -0.291889241157329 0.376434924367265 no 2122 0.385185654890593 3049 6819948
SGTC_982 1491-0518 27.5 µM -0.29442906599353 0.375408651586987 no 2123 0.384215029620702 2922 3091256
SGTC_2740 felodipine 17.08 µM -0.294702241556007 0.375298321272483 no 2124 0.384110675337805 3024 3333 L-type calcium channel blocker
SGTC_293 4049-0273 38.5 µM -0.297017747968562 0.374363543606931 no 2125 0.383226479662744 2971 1380311
SGTC_412 gemfibrozil 100 µM -0.298212530323478 0.373881494287654 no 2126 0.382770479418535 2984 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1002 4049-0206 172 µM -0.29828502052362 0.373852253581506 no 2127 0.382742818053298 2928 4662749
SGTC_3035 9091303 49.47 µM -0.298443087922291 0.37378849572403 no 2128 0.382682503560042 2934 25237002
SGTC_1163 k060-0048 49.9 µM -0.29896603174525 0.37357758641456 no 2129 0.38248298180173 2933 6809982
SGTC_1596 piperlongumine 63 µM -0.299128437611343 0.373512093946549 no 2130 0.38242102450472 3087 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3192 9110362 49.47 µM -0.299306270066703 0.373440384677839 no 2131 0.382353185467587 2901 16649480
SGTC_371 0195-0006 7.36 µM -0.303100825177455 0.371911314059964 no 2132 0.380906512657068 2854 3928593
SGTC_2866 9034245 58.44 µM -0.303906365585266 0.371586968823039 no 2133 0.380599613998016 3006 6462273
SGTC_1746 st038117 42 µM -0.305723543837988 0.370855629676979 no 2134 0.379907572840498 3049 2898218
SGTC_2569 tetrandrine 100 µM -0.306667060424638 0.370476086978508 no 2135 0.379548402200379 2990 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1373 2887-0003 58.5 µM -0.307252308662151 0.370240726030695 no 2136 0.379325666598829 3015 776948
SGTC_2753 fluvastatin 17.09 µM -0.307301418860145 0.370220978289742 no 2137 0.379306977906682 3040 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1367 1812-0510 76.9 µM -0.308810235303593 0.369614433836486 no 2138 0.37873294139998 2992 1142582 YDR527W RBA50
SGTC_1848 st056003 16.4 µM -0.309050061784397 0.369518053385627 no 2139 0.378641722855821 3018 146492
SGTC_1507 4075-3230 155 µM -0.309682630688835 0.369263878618194 no 2140 0.378401156288579 2923 659771
SGTC_1684 st024538 14.6195 µM -0.310717451511895 0.368848196816669 no 2141 0.378007714562102 2952 6732859
SGTC_517 1365-0151 113 µM -0.311354821125535 0.368592245260724 no 2142 0.377765447800201 3123 768657
SGTC_1320 1313-0481 95.3 µM -0.311790020370774 0.36841751370358 no 2143 0.377600054424066 3124 6813365 YLR208W SEC13
SGTC_2167 5876490 200 µM -0.312602455959871 0.368091395399192 no 2144 0.377291355998121 3157 686534
SGTC_1448 4255-0083 152 µM -0.313134984833536 0.36787768549258 no 2145 0.377089055307706 3115 5399660
SGTC_418 lividomycin a 100 µM -0.313309647571676 0.367807600247495 no 2146 0.377022710582386 3095 72394 An antibiotic.
SGTC_1450 4112-4260 37.6 µM -0.313376696389925 0.367780697378875 no 2147 0.376997243404546 3106 1633175
SGTC_688 0527-0193 473 µM -0.313671001501709 0.367662617188718 no 2148 0.376885463713935 2976 4007154
SGTC_552 k242-0005 476 µM -0.314827457486493 0.367198748720579 no 2149 0.376446331495174 3083 4088318
SGTC_233 rapamycin 362 pM -0.315743304645121 0.366831528810233 no 2150 0.376098677230742 2983 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2270 7924575 90.91 µM -0.318003944517834 0.365925620259556 no 2151 0.375240972408759 3121 1262135
SGTC_994 3910-0338 138 µM -0.318369932472251 0.365779027655768 no 2152 0.37510217152443 3151 3479481
SGTC_660 4031-1742 102 µM -0.319329654797472 0.365394714149355 no 2153 0.374738273805963 2971 6738706
SGTC_611 3453-1652 23.7 µM -0.320125646517072 0.365076067800543 no 2154 0.374436542368721 3073 1560575
SGTC_2563 tomatine 8.54 µM -0.320597848964628 0.364887082718783 no 2155 0.374257583957072 3166 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1475 4092-1048 11.7 µM -0.321047884729135 0.364706999741395 no 2156 0.374087051633543 3042 2881759
SGTC_2255 7941087 197.44 µM -0.321693152080042 0.364448846425696 no 2157 0.373842583082602 3117 935561
SGTC_259 usnic acid 108.925 µM -0.322363506191389 0.364180721702911 no 2158 0.373588663801699 3177 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2332 7982454 138.89 µM -0.323249955263592 0.363826266519744 no 2159 0.373252975511892 3055 2981748
SGTC_2822 7994718 71.43 µM -0.323349570598592 0.363786441646269 no 2160 0.373215258312162 2943 1018011
SGTC_1950 st077106 7.18 µM -0.325470371533142 0.362938923685939 no 2161 0.372412551541405 3063 13831864
SGTC_769 0302-0231 76 µM -0.325543960267159 0.362909528054043 no 2162 0.372384708698317 3079 571869 YER009W NTF2
SGTC_1960 st011366 51.8 µM -0.325606420039123 0.36288457861235 no 2163 0.372361077103849 2959 3972846
SGTC_3141 9094609 49.47 µM -0.327626054821076 0.362078153403367 no 2164 0.371597209710849 2929 25236309 YDL196W YDL196W
SGTC_965 1291-5240 308 µM -0.328204166058736 0.361847430348837 no 2165 0.371378649050576 3110 2834598
SGTC_2969 9091408 28.7 µM -0.328221926592678 0.361840342949249 no 2166 0.371371935161572 2949 4286311
SGTC_956 1185-0240 191 µM -0.33124433174986 0.360634934199663 no 2167 0.370229968310874 2996 1416193
SGTC_1631 benzylvanillin 81.9 µM -0.33151964819987 0.360525199870212 no 2168 0.370126001095179 3127 75506
SGTC_2334 9017922 200 µM -0.331677046454454 0.36046246997734 no 2169 0.370066567360992 3116 3163164
SGTC_589 1227-0070 34.1 µM -0.332096252704692 0.360295416797718 no 2170 0.369908289812335 3105 2841384
SGTC_56 0957-0365 83.25 µM -0.33452283221618 0.359328952695096 no 2171 0.368992532341816 3115 6752360
SGTC_3088 9117578 49.47 µM -0.335000657279535 0.359138749130376 no 2172 0.36881229520065 3064 678341
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.33611722611382 0.358694422694675 no 2173 0.368391234401096 3008 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1401 3807-4679 7.6 µM -0.336174014121633 0.358671829627842 no 2174 0.368369823724562 3019 3291456
SGTC_1841 st054148 70 µM -0.336793894823249 0.35842524272803 no 2175 0.368136137856437 3077 675442
SGTC_2265 7929201 200 µM -0.336859745499663 0.358399050969804 no 2176 0.368111315989067 2945 1265108
SGTC_2053 5265679 138 µM -0.337159155480394 0.358279970635702 no 2177 0.367998462819905 2977 764595
SGTC_910 3454-3003 490 µM -0.337390641221089 0.358187914349123 no 2178 0.367911219363273 3131 820824
SGTC_1845 st056753 3.01 µM -0.337973666760833 0.357956095713994 no 2179 0.367691516100894 2947 5375839
SGTC_1243 0416-0003 5.65 µM -0.340551799491799 0.356931625018533 no 2180 0.36672051044909 3017 2141977
SGTC_1989 st071868 50.2 µM -0.340996083345269 0.356755184198183 no 2181 0.366553265133911 3144 16414057
SGTC_3155 9099265 49.47 µM -0.341307427928912 0.356631556519082 no 2182 0.366436078305196 3111 25236499
SGTC_2747 doxorubicin 7.63 µM -0.341859463308402 0.356412393164649 no 2183 0.366228328609719 3035 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2561 acetosyringone 100 µM -0.342310761648234 0.356233258603169 no 2184 0.366058518811717 2967 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.342766074990403 0.356052562506915 no 2185 0.365887224872912 2997 16623 A steroid.
SGTC_3171 9103192 49.47 µM -0.345489007698829 0.35497261276159 no 2186 0.364863386358731 3111 13018434
SGTC_1652 st011932 78 µM -0.34686312049591 0.35442806355235 no 2187 0.364347077046999 3115 1551076
SGTC_2902 5787006 60.46 µM -0.34803247641865 0.353964891953825 no 2188 0.363907896844368 2997 591003
SGTC_1956 st077085 54 µM -0.348309911608238 0.353855033995054 no 2189 0.363803725485078 3045 24208685
SGTC_2264 7948757 110.76 µM -0.348442408780297 0.353802572452494 no 2190 0.363753979000771 2958 2971411
SGTC_1220 1838-0075 193 µM -0.34846664543613 0.353792976379298 no 2191 0.36374487951977 3039 5529645
SGTC_2998 9066762 71.4286 µM -0.349018147350986 0.353574644112512 no 2192 0.363537842806379 3212 4945196
SGTC_3354 9151612 71.43 µM -0.349773602730653 0.353275647568859 no 2193 0.363254305579447 3142 27261949
SGTC_3251 9135047 49.47 µM -0.350891615667952 0.352833323024502 no 2194 0.362834830894612 3101 17682963
SGTC_2776 terbinafine 19.92 µM -0.351677066876231 0.352522690268005 no 2195 0.36254023061878 3079 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_828 2074-0507 139 µM -0.351823318180202 0.352464861187006 no 2196 0.362485384919815 3167 X828
SGTC_1590 st077108 57.8 µM -0.352444425377403 0.352219307821687 no 2197 0.362252494973582 3123 5489485
SGTC_1926 methyl fluorone black 53.6 µM -0.352793314176896 0.3520814024127 no 2198 0.362121698212803 3045 72721 Reacts with homocysteine.
SGTC_2849 9019321 12.99 µM -0.352922543987906 0.352030326631855 no 2199 0.362073254652887 3148 16489627
SGTC_728 3030-5151 22.5 µM -0.35325926121567 0.35189725768707 no 2200 0.361947041980362 3023 3125388
SGTC_946 3434-1334 87.4 µM -0.353534820765764 0.351788371442014 no 2201 0.3618437643825 3156 4047976
SGTC_54 0159-0055 9 µM -0.354793338166273 0.351291228020408 no 2202 0.361372209755928 3264 3319099
SGTC_2026 5148700 152 µM -0.355977878236493 0.350823539667338 no 2203 0.360928566038408 3007 79838
SGTC_1899 st063254 59.6 µM -0.356073124759846 0.350785943577403 no 2204 0.360892901641677 2995 3093813
SGTC_2805 7950783 58.44 µM -0.356397220034604 0.350658026336045 no 2205 0.360771555486926 3143 1178958 YDL195W SEC31
SGTC_213 1246-0773 967 nM -0.357586747890471 0.35018867650165 no 2206 0.36032629853987 3079 6251622
SGTC_2119 5528445 120.635 µM -0.358300562514242 0.349907137726491 no 2207 0.360059198594338 3169 791935
SGTC_1303 1160-0052 261 µM -0.359779013738195 0.349324277790064 no 2208 0.359506199175135 3075 3562476
SGTC_1866 st057638 64 µM -0.361144515730862 0.348786262034266 no 2209 0.358995708456001 3051 688802
SGTC_1987 st072290 61.9 µM -0.362987816641422 0.348060472900486 no 2210 0.358306992723594 3092 54697379
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.363240433158956 0.347961049877905 no 2211 0.358212643020165 3190 16725076
SGTC_1034 k072-0165 12.7 µM -0.364447191344767 0.347486246845433 no 2212 0.357762050642376 3198 5835461
SGTC_2458 5808907 16.39 µM -0.364555090909717 0.347443805040267 no 2213 0.357721771580975 3195 2731747
SGTC_2737 bleomycin 30.5 nM -0.365697479402823 0.34699456911071 no 2214 0.357295413594769 3070 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_35 0133-0054 64.071 µM -0.366213239857295 0.346791820474206 no 2215 0.357102981715582 3091 99677
SGTC_1134 3477-0009 42.5 µM -0.368177646563896 0.34602000214263 no 2216 0.356370388470991 3280 3973534
SGTC_2877 9040724 71.43 µM -0.368551894238804 0.345873032070272 no 2217 0.35623087893318 3227 6463895
SGTC_1354 1498-1681 81 µM -0.368641985616277 0.345837655928386 no 2218 0.356197298146617 3139 5754243
SGTC_2159 5658611 73.75 µM -0.371642591992689 0.344660179681594 no 2219 0.35507948650811 3175 793844
SGTC_445 e6 berbamine 66 µM -0.371932530194317 0.344546483701174 no 2220 0.354971542109063 3147 6610268 A calcium/calmodulin antagonist.
SGTC_1887 st057648 70.8 µM -0.372312537732862 0.344397489315555 no 2221 0.354830082396133 3172 688672
SGTC_3033 9090887 49.47 µM -0.37262073173528 0.344276669504766 no 2222 0.354715370328493 3065 19325384
SGTC_3023 9089636 49.47 µM -0.3739609787699 0.34375144386399 no 2223 0.354216673874902 3164 17249241
SGTC_1708 st033234 31.827 µM -0.375419991341372 0.343180018219824 no 2224 0.353674069710151 3184 674664
SGTC_2927 9011802 47.9 µM -0.377220900739457 0.342475182170125 no 2225 0.353004724558254 3161 43912568
SGTC_2323 6148992 148.28 µM -0.377593741653529 0.342329328911136 no 2226 0.352866207269884 3060 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1503 4585-0012 61.3 µM -0.378225726425925 0.342082153756561 no 2227 0.352631457797966 3236 2922052
SGTC_16 erodoxin 22.806 µM -0.378348502012511 0.342034142921575 no 2228 0.352585859559506 3201 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1352 1496-0991 99 µM -0.378393045272767 0.342016725113479 no 2229 0.352569316939139 3062 3000039
SGTC_2911 7942208 15.64 µM -0.379525694133981 0.341573937031959 no 2230 0.352148763896799 3156 1243384
SGTC_2904 7225135 42.03 µM -0.379715869245181 0.34149961294806 no 2231 0.352078169499558 3186 4446116
SGTC_2576 guaiol 23.12 µM -0.379753418001003 0.341484938899976 no 2232 0.35206423172831 3149 227829
SGTC_1132 3456-3614 2.5 µM -0.379825794584484 0.341456654818189 no 2233 0.352037366731416 3295 3125502
SGTC_2241 6772625 37.8075 µM -0.379834626669741 0.341453203384063 no 2234 0.35203408845725 3115 2285411
SGTC_814 3342-0569 96 µM -0.380068274530142 0.341361902446401 no 2235 0.35194736754785 3128 4346283
SGTC_1348 1493-0373 93.8 µM -0.381801216645488 0.340685022895579 no 2236 0.351304408130716 3125 3010129
SGTC_1934 st074720 32.6 µM -0.381847936661994 0.340666781351045 no 2237 0.351287079862743 3041 17250992
SGTC_89 0302-0250 142.109 µM -0.383118871461048 0.340170695709427 no 2238 0.35081581390391 3114 4203518 YLR208W SEC13
SGTC_3010 9080089 71.4286 µM -0.385455779249882 0.339259249637762 no 2239 0.349949881564647 3178 17027233
SGTC_1399 3562-5772 25 µM -0.387366048513492 0.338514899792067 no 2240 0.349242617478277 3034 23847490
SGTC_121 0557-0495 61.343 µM -0.387754346366278 0.338363673809907 no 2241 0.349098916770985 3105 3104427
SGTC_861 0443-0273 110 µM -0.39132465341815 0.336974411063081 no 2242 0.347778639053777 3189 6149169
SGTC_266 formosanin C 406 nM -0.391869819719959 0.336762473249903 no 2243 0.347577201757643 3178 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_446 go6976 132 µM -0.393250223822956 0.336226061869666 no 2244 0.347067339157554 3208 3501 A protein kinase C inhibitor.
SGTC_126 0417-1624 672.48 µM -0.393602895484621 0.336089070556119 no 2245 0.346937121580554 3226 41912 YDL195W SEC31
SGTC_2018 5133068 143 µM -0.394849371149748 0.335605065725764 no 2246 0.346477028107913 3041 785362
SGTC_323 4013-0906 34.3 µM -0.395042465913584 0.335530111656287 no 2247 0.346405774076489 3188 2910086
SGTC_2778 tioconazole 65.09 nM -0.39546615611462 0.335365669727119 no 2248 0.346249446914174 3113 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3066 9117245 49.47 µM -0.396684140972271 0.33489312322375 no 2249 0.345800198197491 3123 17176980
SGTC_2726 cimetidine 79.27 µM -0.397590920965891 0.334541485754723 no 2250 0.345465877005196 3109 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3268 9137683 49.47 µM -0.398224005690389 0.334296069734137 no 2251 0.345232536090545 3080 1953228
SGTC_237 nikkomycin 200 µM -0.398843892419348 0.334055838541352 no 2252 0.345004116655758 3244 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_967 1306-0166 352 µM -0.39884863919248 0.334053999236809 no 2253 0.345002367755194 3250 4437607
SGTC_555 4296-0685 37 µM -0.399814304384327 0.333679901162055 no 2254 0.344646647079585 3163 2908540 YHR072W ERG7
SGTC_2900 5328528 85.29 µM -0.407107222702581 0.330859989511631 no 2255 0.341964619410251 3122 795359
SGTC_31 0508-1974 57.237 µM -0.408212366654215 0.330433500867323 no 2256 0.341558884892439 3220 6810525
SGTC_1037 k284-1091 78.7 µM -0.408263707004258 0.330413693341517 no 2257 0.341540040614449 3129 3334711
SGTC_826 1683-5028 118 µM -0.408438508995858 0.330346256870239 no 2258 0.341475883177896 3198 722377
SGTC_3210 9128157 49.47 µM -0.409411608912205 0.329970947575774 no 2259 0.341118810854474 3169 17590849
SGTC_1408 3909-7976 48.8 µM -0.4108491727933 0.329416814969504 no 2260 0.340591567013894 3168 24152374
SGTC_202 3594-0513 34.79 µM -0.411839250875056 0.329035390760958 no 2261 0.340228624951776 3149 708429
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.413272558506794 0.328483529193239 no 2262 0.339703466363425 3135 5106787 A p450 inhibitor.
SGTC_147 4466-0538 29.23 µM -0.414224000884736 0.328117404986703 no 2263 0.33935503309075 3339 6742687 YHR072W ERG7
SGTC_2358 9037157 4 µM -0.414256334871589 0.328104965454978 no 2264 0.339343194283208 3210 2388925
SGTC_2123 5259487 200 µM -0.414379727956919 0.328057495418143 no 2265 0.339298016437567 3240 2173474
SGTC_118 0083-0097 135.343 µM -0.416364566023187 0.327294298752316 no 2266 0.338571626531174 3180 5207356
SGTC_746 1095-0025 46.6 µM -0.416584761187994 0.327209675177731 no 2267 0.338491078782624 3295 6749286
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.417499348961692 0.326858283501826 no 2268 0.338156600202048 3234 17037758
SGTC_390 dec-rvkr-cmk 16.7 µM -0.418234112354089 0.326576092907558 no 2269 0.337887978607318 3187 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1016 4226-1401 38 µM -0.419190554132507 0.326208913930236 no 2270 0.337538437439976 3230 2901613
SGTC_1612 st002233 45.4 µM -0.421266194485807 0.325412653107784 no 2271 0.336780356345473 3232 1035021
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.422168100883879 0.325066910122156 no 2272 0.33645116160047 3246 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1624 st003710 6.25 µM -0.422222677305621 0.325045993250981 no 2273 0.336431245291413 3250 24207033
SGTC_75 0159-0059 199.013 µM -0.422235653185309 0.325041020217439 no 2274 0.336426510134059 3409 5377270
SGTC_1700 st030840 7.9285 µM -0.422693677480623 0.324865501404118 no 2275 0.336259384556356 3242 5499307
SGTC_123 0083-0120 66.675 µM -0.424066119641667 0.324339802737911 no 2276 0.335758796678083 3169 16001701
SGTC_3245 9134821 49.47 µM -0.424229752702667 0.324277148246101 no 2277 0.335699132177221 3161 17014901
SGTC_2260 7964312 200 µM -0.424254134147209 0.324267813107316 no 2278 0.335690242477899 3287 231951
SGTC_885 0865-0106 16.8 µM -0.424772326975204 0.324069434177654 no 2279 0.33550132635092 3132 2793380
SGTC_1879 gemcitabine 100 µM -0.425172362649936 0.323916323319847 no 2280 0.335355514886975 3155 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.425280315214772 0.323875010333153 no 2281 0.33531617084065 3236 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_393 acivicin 6.25 µM -0.425776312453375 0.32368522219416 no 2282 0.335135424494691 3103 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1803 st050068 52.4 µM -0.426001505880087 0.323599069421515 no 2283 0.335053374357403 3261 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3206 9114350 49.47 µM -0.428022139752495 0.322826454276 no 2284 0.334317500791384 3235 17087243
SGTC_778 3456-2434 196 µM -0.429018300686667 0.322445840410641 no 2285 0.333954953302875 3266 5539063
SGTC_2867 9039098 71.43 µM -0.429431149270836 0.322288153437002 no 2286 0.333804744637458 3123 6463460
SGTC_2567 aureobasidin a 60 nM -0.429990283149873 0.322074643967177 no 2287 0.333601354753385 3354 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3124 9127567 49.47 µM -0.430787727536165 0.321770235426807 no 2288 0.33331136192458 3310 17592030
SGTC_1164 k060-0068 93.7 µM -0.430837424854675 0.321751268420324 no 2289 0.333293292654551 3148 5963676
SGTC_379 3970-0972 5.9 µM -0.431915565465023 0.321339909931788 no 2290 0.332901390671077 3221 2898042 YBL034C STU1
SGTC_610 4215-0184 155 µM -0.431942993655866 0.321329447715034 no 2291 0.33289142295615 3221 5605015
SGTC_473 2-arachidonoylglycerol 10 µM -0.432007412368373 0.321304876380894 no 2292 0.332868012931454 3113 5282280 An endocannabinoid.
SGTC_2909 7941780 10.49 µM -0.432328453690356 0.321182432731172 no 2293 0.332751354911791 3320 1243215
SGTC_195 4234-0266 16.654 µM -0.432808376785513 0.32099942856884 no 2294 0.332576993606294 3174 2303354
SGTC_1278 0874-0585 172 µM -0.433579186960608 0.320705594409159 no 2295 0.332297025649246 3220 766306
SGTC_2763 lisinopril 49.32 µM -0.434400680279725 0.32039256336485 no 2296 0.33199875192053 3260 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2733 amorolfine 100 µM -0.435483104159156 0.319980299475597 no 2297 0.331605900160181 3224 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2914 7968218 45.32 µM -0.435774367409352 0.319869403664775 no 2298 0.331500221523014 3228 2977111
SGTC_739 1486-1183 203 µM -0.436630608565857 0.319543490944536 no 2299 0.331189630441008 3288 4346692
SGTC_2666 tannic acid 100 µM -0.436788105197454 0.319483557862295 no 2300 0.331132513086283 3276 16134267 A thiamine antagonist.
SGTC_166 k072-0058 166.424 µM -0.43726819630437 0.319300895181306 no 2301 0.330958428632381 3324 5846229
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.439062637524575 0.318618543639031 no 2302 0.330308075271942 3251 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_45 0kpi-0036 14.9 µM -0.439353008735868 0.318508185231035 no 2303 0.33020288510231 3293 2795021
SGTC_1774 st048371 48.465 µM -0.439479562498541 0.318460092277463 no 2304 0.330157043806071 3133 4242727
SGTC_2485 5633444 17.78 µM -0.44000919935189 0.318258852907021 no 2305 0.329965222261121 3224 5724239
SGTC_693 4161-2696 114 µM -0.440037380474459 0.318248146786861 no 2306 0.329955016998196 3267 805759
SGTC_355 1311-2252 105 µM -0.440413307800079 0.318105345029962 no 2307 0.329818894101887 3185 5338538
SGTC_1158 4092-0494 91.8 µM -0.44095946150574 0.317897928347189 no 2308 0.329621172565229 3310 1148199
SGTC_1451 4152-0210 104 µM -0.4423669592468 0.317363656301899 no 2309 0.329111842145948 3321 659563
SGTC_574 1315-0397 40 µM -0.442787085783434 0.31720425412781 no 2310 0.328959872592571 3211 6794277
SGTC_690 glyoxal 20.3 µM -0.442878560487492 0.31716955177649 no 2311 0.328926787808281 3248 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1949 st076024 69.1 µM -0.443266054569223 0.317022567703191 no 2312 0.328786652912128 3117 2921930
SGTC_3302 9125395 16.351 µM -0.443784713804995 0.316825875306099 no 2313 0.328599120599678 3187 17599668
SGTC_3109 9122853 49.47 µM -0.446494820218334 0.315798958033801 no 2314 0.327619926686779 3230 1234709
SGTC_1014 4130-3005 69.3 µM -0.446503805166778 0.315795555802572 no 2315 0.327616682283542 3157 743608
SGTC_1381 2324-0066 62.1 µM -0.446809487690337 0.315679815675596 no 2316 0.327506310177148 3269 10885928
SGTC_1808 st050063 61.5 µM -0.44762360900631 0.315371654306294 no 2317 0.327212430766345 3315 4011993
SGTC_1492 4158-0558 28.5 µM -0.447925222140765 0.315257520221643 no 2318 0.327103582410304 3269 3967268
SGTC_3300 9124615 50.48 µM -0.448610039836381 0.314998442332961 no 2319 0.326856494995097 3346 24824903
SGTC_1082 camptothecin 424.86 nM -0.44929859100229 0.314738043746515 no 2320 0.32660813703504 2982 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_194 1486-1323 56.904 µM -0.452450890330853 0.313547074177624 no 2321 0.325472096214565 3229 5178754
SGTC_221 trifluoperazine 10.304 µM -0.452825139785023 0.313405807733313 no 2322 0.325337329742949 3269 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2886 9058944 51.95 µM -0.454705503474005 0.312696448924333 no 2323 0.324660560505072 3178 4949929
SGTC_2582 agaric acid 100 µM -0.455545247156678 0.312379883107578 no 2324 0.324358511704545 3297 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2165 5727197 32.143 µM -0.456520450622771 0.312012425506585 no 2325 0.324007884140801 3499 1361712
SGTC_3311 9131146 2.8755 µM -0.45905390128278 0.31105869343004 no 2326 0.323097729740416 3235 4900406 YPR165W RHO1
SGTC_3331 9141060 1.957 µM -0.459264440738982 0.310979491596311 no 2327 0.323022139969467 3188 4906567 YPR165W RHO1
SGTC_3041 9091929 49.47 µM -0.461531964746834 0.310127038042093 no 2328 0.322208496871583 3387 25236887
SGTC_1603 st002045 67.8 µM -0.461542299293988 0.310123155200107 no 2329 0.322204790528939 3323 5887985
SGTC_1530 rhein 70.4 µM -0.461785751148647 0.310031692867505 no 2330 0.322117484996847 3272 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2683 piperine 63.03 µM -0.462548915137399 0.309745056277114 no 2331 0.321843866425747 3232 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.462605107343642 0.309723955628077 no 2332 0.321823723547494 3209 390807
SGTC_1545 lovastatin 49.4 µM -0.462605923698483 0.309723649084545 no 2333 0.3218234309176 3287 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2089 5281248 129.67 µM -0.467234154194335 0.30798786794127 no 2334 0.320166180161109 3264 2737878
SGTC_19 0279-0214 38.434 µM -0.469267256749074 0.307226721715716 no 2335 0.319439308283139 3274 3566274 YBR002C RER2
SGTC_767 0929-0023 86 µM -0.471739391163977 0.306302330052656 no 2336 0.31855640843522 3347 1204563
SGTC_580 1123-0028 41 µM -0.473739374873001 0.305555387890081 no 2337 0.317842885636852 3302 1677248 YPR107C YTH1
SGTC_922 1866-0035 480 µM -0.474516819883523 0.305265250356062 no 2338 0.317565703274767 3215 3156169
SGTC_2583 asiatic acid 100 µM -0.474639981343936 0.305219298500484 no 2339 0.317521801913939 3399 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3119 9125183 49.47 µM -0.475401164544623 0.304935367242728 no 2340 0.317250532291939 3223 22695334
SGTC_1334 1486-0610 236 µM -0.475437489326142 0.304921820559444 no 2341 0.317237589359347 3314 3742339
SGTC_1229 0139-0193 12.2 µM -0.476347992150909 0.304582352055831 no 2342 0.316913239906957 3372 3090752
SGTC_1777 st045864 34.765 µM -0.476463069649556 0.304539458956497 no 2343 0.31687225572632 3315 4691462
SGTC_2710 st078562 53.7235 µM -0.477134784034158 0.304289142962859 no 2344 0.316633073414713 3232 17250908
SGTC_1674 st016616 23.6 µM -0.479832953226402 0.30328458825856 no 2345 0.315673089458847 3186 625830
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.481861678957755 0.302530251692759 no 2346 0.314952105116368 3271 4620898
SGTC_2072 5231554 129 µM -0.482407570535753 0.302327417735924 no 2347 0.314758222105576 3385 789545
SGTC_2061 5245884 80.95 µM -0.486949181584734 0.300642286782369 no 2348 0.313147172249728 3249 573863
SGTC_1480 1070-0044 41.2 µM -0.487067335373387 0.300598503335946 no 2349 0.313105306837005 3324 3124987
SGTC_141 0443-0274 32.331 µM -0.487115869401783 0.300580519245069 no 2350 0.313088110480668 3437 1627241
SGTC_554 4483-2211 187 µM -0.488853810629211 0.299936852481776 no 2351 0.312472599209351 3309 747107
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.489209698572136 0.299805122227035 no 2352 0.31234662195766 3365 61125 An anti-inflammatory.
SGTC_1228 0124-0032 52.5 µM -0.489394631183296 0.29973668063212 no 2353 0.312281168150728 3355 X1228
SGTC_1648 st011736 69.8 µM -0.490123242988717 0.299467098031251 no 2354 0.312023345840119 3408 2855514
SGTC_802 4112-3352 742 µM -0.491403514585615 0.298993670626621 no 2355 0.311570539473451 3382 704594
SGTC_1162 k048-0130 20.1 µM -0.491680919666654 0.298891134737038 no 2356 0.311472464383122 3263 6797406
SGTC_1197 1601-0112 267 µM -0.49418257223423 0.297967183598027 no 2357 0.31058862333574 3255 7350313
SGTC_2630 antimycin a 100 µM -0.496030448919983 0.297285532798193 no 2358 0.309936464169278 3260 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_706 4262-0057 46.9 µM -0.496247654519507 0.297205456108476 no 2359 0.309859846413066 3281 883298
SGTC_2428 5615643 7.78 µM -0.497393858604392 0.296783051061666 no 2360 0.30945566777266 3345 2253075
SGTC_963 1269-2853 151 µM -0.497660368361949 0.296684874902983 no 2361 0.309361723129439 3259 3668223
SGTC_2101 5377231 179.231 µM -0.497678349235563 0.296678251691964 no 2362 0.309355385323213 3359 2844213
SGTC_662 k832-1615 104 µM -0.498538656418675 0.296361438789926 no 2363 0.309052214955114 3338 5878478
SGTC_1616 st002734 56.1 µM -0.499320137980233 0.29607378837349 no 2364 0.308776935238534 3243 4026101
SGTC_2528 xanthyletin 44.79 µM -0.500527622681369 0.295629585386289 no 2365 0.308351805583212 3254 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.501295086209097 0.295347414352136 no 2366 0.308081731497372 3313 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1705 st027868 56.3335 µM -0.501886322344581 0.295130120863668 no 2367 0.30787374350925 3341 292948
SGTC_3024 9090631 49.47 µM -0.503562596201713 0.294514450536326 no 2368 0.307284391228111 3374 25236383
SGTC_1101 ebselen 5.29 µM -0.503991279585593 0.294357096761462 no 2369 0.307133752495185 3423 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3153 9100258 49.47 µM -0.504509977335732 0.294166753970121 no 2370 0.306951526353202 3268 25236848
SGTC_3219 9131112 49.47 µM -0.505348021981088 0.293859342971412 no 2371 0.306657209719617 3356 17612988 YMR079W SEC14
SGTC_1293 1000-1278 195 µM -0.507249518129323 0.293162389046475 no 2372 0.305989877211779 3419 678847
SGTC_1570 verbenone 133 µM -0.507767820176271 0.292972549215981 no 2373 0.305808089950668 3424 29025 A natural terpanoid with antifungal properties.
SGTC_2364 9055074 200 µM -0.508103946023259 0.292849466032184 no 2374 0.305690224035401 3357 6470630
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.508442638110821 0.29272546742265 no 2375 0.305571478601373 3470 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3353 9151644 39.2805 µM -0.510330152651802 0.292034876201744 no 2376 0.304910090842885 3395 4909158
SGTC_14 0354-0009 295 µM -0.511615110529878 0.291565178736059 no 2377 0.304460203987834 3321 1713507
SGTC_2439 5492030 7.2 µM -0.511795348334256 0.291499323636472 no 2378 0.30439712312381 3364 5722370
SGTC_1126 isoteolin 1.0172 µM -0.513077493447585 0.2910310551323 no 2379 0.303948557182261 3331 133323
SGTC_1702 st027038 51 µM -0.513684426059584 0.290809512177974 no 2380 0.303736321107069 3353 5521182
SGTC_3078 9116413 49.47 µM -0.514577315236096 0.290483732558822 no 2381 0.303424210187208 3287 17177322
SGTC_410 α-linolenic acid 100 µM -0.514657690590881 0.290454415182372 no 2382 0.303396121877192 3418 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_854 0422-0053 192 µM -0.515901517215567 0.290000898876541 no 2383 0.302961597182114 3392 3596728
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.51958198102954 0.288660899373211 no 2384 0.301677479858105 3426 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2383 9036125 200 µM -0.519742216785571 0.288602626337253 no 2385 0.301621629087487 3311 79580
SGTC_1271 0832-2808 169 µM -0.520055209872902 0.288488815936018 no 2386 0.301512547595822 3422 3663794
SGTC_220 paclitaxel 373.376 µM -0.520114111978 0.288467400344842 no 2387 0.301492021556937 3376 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_312 4092-0653 6.84 µM -0.520916962933259 0.288175575021051 no 2388 0.301212309048062 3381 1148278
SGTC_777 1315-0167 517 µM -0.521344483405821 0.288020234036405 no 2389 0.301063409035776 3357 4221767
SGTC_2529 gangaleoidin 93.61 µM -0.522028099178661 0.287771922137478 no 2390 0.300825383209027 3304 4565183
SGTC_2465 5809242 33.21 µM -0.522276284144611 0.287681798164647 no 2391 0.300738989547781 3372 2731748
SGTC_1664 st014217 9.02 µM -0.522585902718189 0.287569384368411 no 2392 0.300631226429141 3452 3982782
SGTC_608 k048-0125 159 µM -0.523017807002092 0.287412606767146 no 2393 0.300480930746699 3420 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_313 3474-0040 5.03 µM -0.523743797190988 0.287149169599617 no 2394 0.300228374440257 3331 1043375 YIL048W NEO1
SGTC_1713 st033146 12.748 µM -0.524631307781942 0.286827277543976 no 2395 0.29991975911396 3449 674619
SGTC_3120 9124077 49.47 µM -0.525875132114187 0.286376441718499 no 2396 0.299487484097059 3414 18774327 YGL155W CDC43
SGTC_2812 7970281 58.44 µM -0.527559150081065 0.285766590090075 no 2397 0.298902675989611 3444 2233435
SGTC_3187 9109394 49.47 µM -0.532581366951231 0.283951517784503 no 2398 0.297161701660992 3338 17098090
SGTC_2711 st079103 59.1 µM -0.533474058801862 0.283629469657472 no 2399 0.296852731835215 3352 54693780
SGTC_2250 alverine citrate 130 µM -0.53362950217327 0.283573409691554 no 2400 0.296798946319347 3373 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1840 st055363 71 µM -0.53412921688542 0.283393225762001 no 2401 0.29662606847657 3362 676033
SGTC_2618 avocadyne 43.43 µM -0.534551774903383 0.283240905342623 no 2402 0.296479919229951 3355 3015189
SGTC_2708 st078559 56 µM -0.535827489115508 0.282781284226754 no 2403 0.296038890987853 3385 17250902
SGTC_1065 prochlorperazine maleate 2.48 µM -0.535845086599044 0.282774946617706 no 2404 0.296032809452958 3454 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1186 1319-0216 26 µM -0.536572548214429 0.28251301620227 no 2405 0.295781455343777 3470 4565136
SGTC_411 enrofloxacin 100 µM -0.540434010242312 0.281124611649856 no 2406 0.294448879211601 3495 71188 A bacterial gyrase inhibitor.
SGTC_2425 5628681 7.85 µM -0.54081036642921 0.280989467700441 no 2407 0.294319148443554 3413 5714958
SGTC_1694 st024011 44.9 µM -0.540905483204292 0.280955317641501 no 2408 0.294286365670448 3459 2787533
SGTC_1901 st060216 58.6 µM -0.541230426554137 0.280838667396876 no 2409 0.294174384016173 3397 688792
SGTC_3256 9138902 49.47 µM -0.541277617343033 0.280821728492718 no 2410 0.294158122810815 3391 17228773
SGTC_319 1348-1596 45.5 µM -0.542020294368658 0.280555213268143 no 2411 0.293902262684015 3484 5380505
SGTC_920 mycophenolic acid 780.421 nM -0.543038988651335 0.280189846392058 no 2412 0.293551479191911 3357 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_978 1416-0512 87.4 µM -0.543721554082441 0.279945165197018 no 2413 0.293316548912757 3430 6814003
SGTC_3002 9075603 71.4286 µM -0.544113142121961 0.279804838290822 no 2414 0.29318180867109 3443 20105405
SGTC_2184 6075246 200 µM -0.544422157338755 0.279694125730636 no 2415 0.293075500904279 3407 2267320
SGTC_2032 5185112 25.99 µM -0.545963495306999 0.279142219892588 no 2416 0.292545515261516 3347 5718189
SGTC_2731 amoxapine 43.43 µM -0.546491073517882 0.278953432021404 no 2417 0.292364211030067 3435 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1397 3532-0190 20.1 µM -0.547001227304716 0.278770938369687 no 2418 0.29218894447169 3331 5322280
SGTC_1773 st048542 73.5835 µM -0.54867377146165 0.278173039048233 no 2419 0.291614674502262 3322 3237138
SGTC_900 1112-0045 141 µM -0.549805908269308 0.277768679219714 no 2420 0.291226252907198 3390 56211 YIL048W NEO1
SGTC_345 1362-0200 395 µM -0.550566798679925 0.277497077045239 no 2421 0.29096533696925 3376 1419823
SGTC_1149 3909-7961 23.3 µM -0.55298218156267 0.276635759665665 no 2422 0.290137805735838 3405 735261
SGTC_2324 6149169 200 µM -0.553976573096547 0.276281544135671 no 2423 0.289797439312153 3347 2888231
SGTC_637 1181-0519 7.26 µM -0.554740480612357 0.276009581315071 no 2424 0.289536091667983 3458 6252091 YGR060W ERG25
SGTC_375 3970-0961 9.27 µM -0.554758341308006 0.276003224205969 no 2425 0.289529982500328 3375 2898222
SGTC_1184 1269-1718 139 µM -0.554765697216524 0.276000606058247 no 2426 0.289527466463722 3477 5403821
SGTC_1363 1636-0063 10.4 µM -0.55605827885556 0.27554073410914 no 2427 0.289085507538463 3417 6072185
SGTC_2129 girgensonine 121.053 µM -0.556523364477013 0.27537535917344 no 2428 0.288926563331311 3393 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1056 3448-1962 115 µM -0.557929083731017 0.274875811250347 no 2429 0.288446405313764 3426 715507
SGTC_2681 menadione 3.18 µM -0.558343246220075 0.274728716295614 no 2430 0.288305009682737 3472 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_640 3381-0960 37.1 µM -0.558351594377473 0.27472575174287 no 2431 0.288302159946648 3458 1745025
SGTC_2943 9068529 45.32 µM -0.559129127495876 0.274449707536096 no 2432 0.288036798646773 3486 3270634
SGTC_3006 9075424 71.4286 µM -0.559401634577731 0.274352992934815 no 2433 0.287943823038355 3381 7465181
SGTC_3040 9091894 49.47 µM -0.55965926948985 0.274261572042088 no 2434 0.287855934639485 3384 25236966
SGTC_3087 9117406 49.47 µM -0.561113040694115 0.273745988267173 no 2435 0.287360239363687 3452 42546093
SGTC_2127 5253358 187.912 µM -0.561513910939813 0.27360390294955 no 2436 0.287223624896416 3369 20612
SGTC_682 0kpi-0099 17 µM -0.561778830269642 0.273510024400142 no 2437 0.287133358658197 3460 1714895 YML126C ERG13
SGTC_1913 st060213 96.1 µM -0.562489198576556 0.273258372355361 no 2438 0.286891380442338 3512 688959
SGTC_2963 9082507 9 µM -0.565472009311292 0.272202948135819 no 2439 0.285876378822144 3469 16459611
SGTC_2616 abietic acid 100 µM -0.56599160013853 0.272019305887331 no 2440 0.28569974534185 3489 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_794 k038-0031 316 µM -0.566610635174261 0.271800596905635 no 2441 0.285489373876725 3512 6624242
SGTC_2873 9040596 71.43 µM -0.567042504263289 0.271648066670043 no 2442 0.285342652148264 3475 6463863
SGTC_2575 plumbagin 510 nM -0.567338410543135 0.271543581241622 no 2443 0.285242142699676 3398 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_951 1171-0579 82.7 µM -0.567646948186679 0.271434656958474 no 2444 0.285137360767863 3472 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1768 st044301 37.178 µM -0.568698756836572 0.271063496392372 no 2445 0.28478029580807 3406 3931349
SGTC_931 2812-0076 566 µM -0.57015736942817 0.270549202777221 no 2446 0.284285483640786 3413 3450959
SGTC_2719 novobiocin 32.65 µM -0.571813214846545 0.269965958047776 no 2447 0.283724261796298 3507 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_776 4476-4378 112 µM -0.573474911691818 0.269381285530829 no 2448 0.283161590658328 3477 2892008
SGTC_2160 5660466 132.927 µM -0.575338198469213 0.268726438974578 no 2449 0.282531296129335 3464 2859134
SGTC_2090 5301565 104.445 µM -0.575726980278397 0.268589903682994 no 2450 0.282399867906811 3450 2056344
SGTC_1993 st073995 70.8 µM -0.576344842133628 0.26837299011103 no 2451 0.282191059385111 3434 3098394
SGTC_192 3455-0609 60.9 µM -0.578160746495949 0.26773598857372 no 2452 0.281577798842256 3529 3769639
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.578817203695345 0.267505897430493 no 2453 0.281356260826339 3393 23665772 A membrane-active detergent.
SGTC_454 lyso-paf C-16 6.67 µM -0.5815319157373 0.266555438879581 no 2454 0.280441007242155 3440 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2433 5607874 27.82 µM -0.581672853865593 0.266506141148039 no 2455 0.280393529938129 3469 2252428
SGTC_2030 5175110 200 µM -0.582303008032856 0.266285780483568 no 2456 0.280181299855972 3535 2831986
SGTC_1670 st016595 4.04 µM -0.582577258211356 0.266189905853802 no 2457 0.280088959251759 3484 597879
SGTC_1772 st048439 82.2 µM -0.583457671215025 0.265882241993932 no 2458 0.279792622084951 3460 2927068 YDL195W SEC31
SGTC_1739 st037196 92.5 µM -0.583742456860726 0.265782761091602 no 2459 0.279696798990617 3514 612214
SGTC_2448 5185112 27.17 µM -0.585529073128742 0.26515909369425 no 2460 0.279096011879592 3486 5718189
SGTC_1930 st074634 34.3 µM -0.58562663656909 0.265125057913304 no 2461 0.279063222207481 3454 684253 YOR116C RPO31
SGTC_1047 2043-3044 82 µM -0.585995087742329 0.264996540811906 no 2462 0.278939407954659 3441 669592
SGTC_249 wiskostatin 11.211 µM -0.586694269116874 0.2647527508749 no 2463 0.278704528693874 3504 2775510 A n-wasp and actin depolymerizer.
SGTC_187 1488-2104 32.728 µM -0.587304494788106 0.264540071171104 no 2464 0.278499611459878 3498 2852859
SGTC_1391 3442-0225 151 µM -0.58849710218802 0.264124667212855 no 2465 0.278099339172042 3452 5227075
SGTC_744 1594-0068 283 µM -0.58911208931829 0.263910587434206 no 2466 0.2778930420702 3500 668392
SGTC_2120 5538279 151.968 µM -0.589907106974716 0.26363396936185 no 2467 0.277626464574966 3507 2058197
SGTC_2628 lathosterol 100 µM -0.59034387114149 0.263482064819571 no 2468 0.277480066302628 3552 6710616
SGTC_790 1575-0012 79.1 µM -0.590921497956818 0.263281237536317 no 2469 0.277286510475017 3537 378741 YLR208W SEC13
SGTC_2254 7938975 95.19 µM -0.591151079978993 0.263201438972844 no 2470 0.277209598631338 3574 2969277
SGTC_1050 3232-1156 69.3 µM -0.591171045564499 0.263194499880001 no 2471 0.277202910491179 3429 700529
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.591529822830303 0.263069821808733 no 2472 0.277082739511213 3454 688664
SGTC_1864 st057645 30.4 µM -0.592115878279652 0.26286622762424 no 2473 0.276886497485438 3544 688666
SGTC_449 xestospongin c 11.1929 µM -0.594244959496277 0.262127268813122 no 2474 0.276174143006177 3489 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1971 st069429 63.5 µM -0.595029938983414 0.261855087979093 no 2475 0.275911729326511 3507 1246522 YGL099W LSG1
SGTC_499 genistein 192 µM -0.596236630876326 0.261436967026326 no 2476 0.275508578865662 3516 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3279 9140807 49.47 µM -0.596287479405004 0.261419355448739 no 2477 0.275491596959479 3528 45595718
SGTC_2404 5161160 200 µM -0.59676036860158 0.26125559769662 no 2478 0.275333690604205 3501 2831543
SGTC_1150 3909-7983 10.9 µM -0.59695112246037 0.261189556079751 no 2479 0.27527000701043 3439 23965914
SGTC_2091 4-phenylthiadiazole 200 µM -0.59737281630037 0.26104359030783 no 2480 0.275129249333817 3463 270010
SGTC_178 4092-0806 87.505 µM -0.597545203263677 0.260983932090349 no 2481 0.275071718297264 3520 2169044
SGTC_140 0062-0056 502.533 µM -0.598170223783104 0.260767689096193 no 2482 0.274863178684221 3472 3758964
SGTC_2186 6124449 200 µM -0.600451155191792 0.259979321132686 no 2483 0.27410280209117 3491 3834182 YLR033W RSC58
SGTC_1311 1190-0148 100 µM -0.600500708624709 0.259962207422417 no 2484 0.274086294384636 3554 1961333
SGTC_1093 fluphenazine 7.97 µM -0.60128427892752 0.25969167183557 no 2485 0.273825329373115 3533 6602611 An atypical antipsychotic.
SGTC_966 1300-0360 30.2 µM -0.601733100014193 0.259536777289527 no 2486 0.273675906636492 3481 70588
SGTC_378 3970-0959 8.33 µM -0.603299234771315 0.258996655816488 no 2487 0.273154820967353 3518 6615653
SGTC_1710 st031758 61.5 µM -0.603349700531851 0.258979261086573 no 2488 0.273138038137064 3567 5394341
SGTC_868 0527-0199 213 µM -0.604371673046539 0.258627133784474 no 2489 0.272798282225926 3425 2849450
SGTC_857 0438-0306 1.35 µM -0.604841547994434 0.25846531853066 no 2490 0.272642142158081 3560 4686136
SGTC_1936 st074407 74.3 µM -0.605975317687872 0.258075087650834 no 2491 0.272265571718958 3474 809813
SGTC_626 0214-0009 33 µM -0.607551434543198 0.257533113852458 no 2492 0.271742509763594 3552 3437874
SGTC_2162 5663267 200 µM -0.608019573971267 0.257372250329594 no 2493 0.271587245898311 3532 6456493
SGTC_2020 4017018 200 µM -0.608111721240534 0.257340592550458 no 2494 0.27155668939306 3523 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_438 sphingosine 6.67 µM -0.608767562674061 0.257115332535438 no 2495 0.271339258493018 3369 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1665 st014639 11.4 µM -0.609018334379987 0.257029227789319 no 2496 0.271256143164722 3584 981133 YIL048W NEO1
SGTC_911 3456-4043 236 µM -0.609176474547028 0.256974936637239 no 2497 0.271203735994671 3538 914281
SGTC_3271 9137798 49.47 µM -0.611683557252694 0.256115026937798 no 2498 0.2703735714001 3489 6498326
SGTC_1581 himbacine 57.9 µM -0.612483508121345 0.255840966216533 no 2499 0.270108953040313 3498 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3262 9137218 49.47 µM -0.613426759617852 0.25551800789894 no 2500 0.269797098335086 3419 17650664
SGTC_2580 diallyl disulphide 81.36 µM -0.613889092107486 0.255359788459485 no 2501 0.269644309356718 3505 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_675 1309-0189 238 µM -0.614882260597839 0.255020079532347 no 2502 0.269316239393115 3487 4246530
SGTC_1049 3226-0134 66 µM -0.617710007055837 0.254054157693057 no 2503 0.268383257151798 3569 5702385
SGTC_3140 9094243 49.47 µM -0.617888242020078 0.253993339285495 no 2504 0.268324505087436 3589 19291112
SGTC_1632 st005650 90 µM -0.618355755455124 0.253833847842959 no 2505 0.268170428138677 3517 2759605
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.61901008741579 0.253610711879949 no 2506 0.267954856780116 3618 688664
SGTC_2935 9038016 29.96 µM -0.619629732806812 0.253399499524631 no 2507 0.267750793478888 3550 6463195
SGTC_1248 0469-0687 58.6 µM -0.619911659635681 0.25330343254324 no 2508 0.267657974496359 3521 4017482
SGTC_513 4245-1575 41.7 µM -0.620054721200081 0.253254691429076 no 2509 0.267610880433178 3537 719745
SGTC_1461 k072-0203 53.8 µM -0.620357302438874 0.253151618165586 no 2510 0.267511288266339 3494 5418714
SGTC_3167 9103034 49.47 µM -0.620382930968662 0.253142888908279 no 2511 0.267502853701694 3542 5127859
SGTC_516 3992-2719 87.3 µM -0.62082016822991 0.252993987219429 no 2512 0.267358975905765 3462 5350887 YDR037W KRS1
SGTC_1661 st013063 9.66 µM -0.621733011746755 0.252683265843875 no 2513 0.267058720454583 3573 721395
SGTC_2673 kobusone 100 µM -0.622472237723789 0.252431789227084 no 2514 0.266815696679892 3594 6710676 An epoxy ketone and protein crosslinker.
SGTC_731 3966-0296 387 µM -0.6240809296453 0.251884985958131 no 2515 0.266287218663822 3577 660956
SGTC_1446 4239-0190 62 µM -0.625345928041304 0.251455445531714 no 2516 0.265872021240803 3528 1340085
SGTC_1302 1159-0335 255 µM -0.627121266515215 0.25085326849651 no 2517 0.265289873945136 3557 649284
SGTC_2285 7945142 200 µM -0.627314010495724 0.250787937637428 no 2518 0.265226710655938 3570 2970608
SGTC_1785 bathophenanthroline 24 µM -0.628225775430749 0.25047901569579 no 2519 0.26492802367554 3503 72812 An iron chelator.
SGTC_1747 st037496 66.6 µM -0.628769818645541 0.250294780424591 no 2520 0.264749880888777 3553 723305
SGTC_1340 1486-1359 257 µM -0.628998393840256 0.250217396959962 no 2521 0.264675053865622 3519 4309068
SGTC_545 4218-0007 221 µM -0.629826036558255 0.249937307109493 no 2522 0.264404204412631 3543 2840508
SGTC_3303 9125618 40.5795 µM -0.63148736894641 0.249375583626286 no 2523 0.263860952759571 3559 22695467
SGTC_3269 9137823 49.47 µM -0.633034210581082 0.248853175229993 no 2524 0.263355651386397 3498 17682936
SGTC_1838 st055369 84.5 µM -0.633459870897407 0.248709521020723 no 2525 0.263216689151664 3548 676036
SGTC_3015 9080845 49.47 µM -0.635511747854487 0.248017662159117 no 2526 0.262547353615715 3588 5296973
SGTC_691 1548-0686 185 µM -0.635903170813997 0.247885797561074 no 2527 0.26241976792929 3536 46495133
SGTC_860 0443-0016 25.1 µM -0.636083828643161 0.247824949237729 no 2528 0.262360892585264 3586 5337942
SGTC_1121 fusaric acid 630.51 nM -0.638502639230389 0.247011025430325 no 2529 0.261573268289242 3551 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1935 st074532 41.6 µM -0.639443568720676 0.246694791807855 no 2530 0.261267206705022 3651 2829742
SGTC_2839 9003951 25.97 µM -0.63976096091847 0.246588169521391 no 2531 0.261164008221137 3568 2990634
SGTC_1396 3511-0007 98.6 µM -0.640063632845986 0.246486515247425 no 2532 0.261065615477075 3527 X1396
SGTC_2614 arthonioic acid 13.39 µM -0.640279595928611 0.246413996414111 no 2533 0.260995421739619 3544 6710684
SGTC_2317 5986382 200 µM -0.641259915197223 0.246084956133079 no 2534 0.260676913990016 3628 877883
SGTC_1888 azatryptophan 97.5 µM -0.642594107834415 0.245637518575925 no 2535 0.260243753675494 3550 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1155 4088-0394 48.2 µM -0.64276452835839 0.24558039748768 no 2536 0.260188451504505 3544 2326248
SGTC_2722 naftopidil 47.16 µM -0.643099581934643 0.245468115946414 no 2537 0.260079742883785 3562 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2240 6690706 185.951 µM -0.643354340776038 0.245382760853501 no 2538 0.259997101680856 3520 805876
SGTC_26 0302-0163 425.158 µM -0.644356075787023 0.245047291567542 no 2539 0.259672280290126 3585 3100915
SGTC_1676 st018489 23.4 µM -0.645547751009793 0.244648535065206 no 2540 0.25928614210679 3559 3696235
SGTC_969 1313-0238 134 µM -0.649070142225413 0.243471923710753 no 2541 0.258146519897812 3604 5212874
SGTC_1853 st056710 91.2 µM -0.64926482329536 0.24340698216852 no 2542 0.258083609281112 3667 269167
SGTC_1036 k216-0215 33.5 µM -0.649619999187832 0.24328852702048 no 2543 0.257968855720298 3598 622330
SGTC_3070 9117005 49.47 µM -0.65013207794114 0.243117797865605 no 2544 0.257803455112715 3627 8779016
SGTC_1827 berberine 7.24 µM -0.651540618214936 0.24264851914134 no 2545 0.257348782956495 3518 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2290 7904846 200 µM -0.651610138937124 0.242625369858681 no 2546 0.257326352692936 3599 2962154
SGTC_680 0417-1641 114 µM -0.654386735094761 0.241701786339289 no 2547 0.256431339144631 3580 2835990
SGTC_1119 parthenolide 318.541 nM -0.654409189032352 0.241694325237711 no 2548 0.256424107914871 3658 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2531 methyl deoxycholate 70.07 µM -0.655913268053196 0.241194827462841 no 2549 0.255939965388719 3576 16667744 Haematoxylin.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.657026359999692 0.240825536281258 no 2550 0.255581983609767 3569 689007
SGTC_2007 4011539 71.82 µM -0.657620297138946 0.240628611342329 no 2551 0.255391074401261 3615 45595301
SGTC_2097 5376186 200 µM -0.65798434657434 0.240507950982707 no 2552 0.255274094845051 3586 742755
SGTC_572 0960-0087 17.7 µM -0.658182475292953 0.240442297148321 no 2553 0.255210442161099 3584 6796365
SGTC_2036 5160441 105 µM -0.65863298710918 0.240293047565994 no 2554 0.255065737420076 3618 134534 YIL048W NEO1
SGTC_1822 st052468 42 µM -0.65937525137265 0.240047253759474 no 2555 0.254827415213031 3575 2873678
SGTC_2136 5328288 199.296 µM -0.659627282216496 0.239963827308048 no 2556 0.254746521024919 3572 262395
SGTC_1931 st074438 57.1 µM -0.659900056597549 0.239873552216611 no 2557 0.254658983949231 3587 2787313
SGTC_2973 9094665 17.96 µM -0.660233065440211 0.239763367556782 no 2558 0.254552138159668 3628 25237061 YIL048W NEO1
SGTC_904 1141-0088 396 µM -0.662747611536807 0.238932256621885 no 2559 0.2537461055725 3572 1378119
SGTC_1978 st071761 42 µM -0.665721378202178 0.237951400162349 no 2560 0.252794603186293 3563 5147680
SGTC_349 k015-0014 24 µM -0.666186784260833 0.237798092337045 no 2561 0.252645859542669 3603 2196908
SGTC_2237 6667747 47.222 µM -0.668079306727125 0.237175241353763 no 2562 0.252041485072076 3559 729940 YDL015C TSC13
SGTC_404 fumagillin 50 µM -0.668296465880684 0.237103829134436 no 2563 0.2519721844106 3608 12015870 A methionine aminopeptidase binder.
SGTC_925 2064-1272 59.6 µM -0.668989777862521 0.236875914396133 no 2564 0.251750999349504 3599 6815817
SGTC_3352 9151559 45.5865 µM -0.669582859428688 0.236681044361769 no 2565 0.251561871865082 3599 17159339
SGTC_3011 9081274 71.4286 µM -0.670136913125626 0.236499077494711 no 2566 0.251385257799059 3622 6625322
SGTC_197 4544-0043 41.561 µM -0.672706390333961 0.235656196001218 no 2567 0.25056705065669 3628 896523
SGTC_2239 6685329 187.64 µM -0.673276983994617 0.235469245709765 no 2568 0.250385546259086 3636 805680
SGTC_1943 st076331 65.2 µM -0.673521830755147 0.235389048795955 no 2569 0.250307682499139 3686 24208415
SGTC_1731 st035964 63 µM -0.67363846265182 0.235350852578564 no 2570 0.25027059688437 3619 6739575
SGTC_2686 alizarin 95.37 µM -0.674309331575278 0.235131213648655 no 2571 0.250057336299227 3605 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2592 piperlongumine 83.33 µM -0.674328410192873 0.235124969066355 no 2572 0.250051272862796 3603 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1097 itavastatin 7.23 µM -0.674490759476595 0.235071834569139 no 2573 0.249999679274407 3657 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1583 clindamycin 39.6 µM -0.675056038976578 0.234886878790765 no 2574 0.249820081064545 3564 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1925 st057770 10.1 µM -0.677808035725029 0.233987593186942 no 2575 0.248946707684041 3582 5989122
SGTC_2641 levomentholum 100 µM -0.678251059889593 0.233843002104868 no 2576 0.248806261589749 3606 16666
SGTC_1999 st074831 12.5 µM -0.678718272243637 0.233690570310373 no 2577 0.248658193147464 3631 17112523
SGTC_2314 7727897 200 µM -0.678885997311632 0.233635862095602 no 2578 0.248605049348053 3632 900724
SGTC_335 4077-0256 27.6 µM -0.679468551825378 0.233445900848489 no 2579 0.248420513574197 3660 3121989
SGTC_2854 9024559 71.43 µM -0.679724226306678 0.23336255675308 no 2580 0.248339546634679 3622 3163529
SGTC_648 0375-0473 33.3 µM -0.681301514652416 0.232848761697513 no 2581 0.247840362546243 3650 1713139
SGTC_694 1315-0438 43.2 µM -0.681615170886179 0.23274666446435 no 2582 0.247741159738537 3594 6793154
SGTC_745 0469-0705 296 µM -0.681678949260233 0.232725907214721 no 2583 0.247720990587157 3727 3486736
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.68172393374486 0.232711267225425 no 2584 0.247706765306875 3614 6857784
SGTC_2983 9022671 12.99 µM -0.682536945332919 0.232446764658647 no 2585 0.247449744807274 3644 6405161
SGTC_1247 0448-0043 5.84 µM -0.682734732101596 0.2323824426445 no 2586 0.247387239270182 3683 3089013 YGL099W LSG1
SGTC_1432 4049-0298 68.4 µM -0.684502992862479 0.23180782867216 no 2587 0.246828800073096 3655 741646
SGTC_2717 st081029 62.2815 µM -0.685697891303701 0.231419983084967 no 2588 0.246451818389484 3630 5292846
SGTC_2062 5245942 200 µM -0.686143119172026 0.231275561578281 no 2589 0.246311431205196 3721 1376160
SGTC_3255 9139072 49.47 µM -0.68622493601124 0.231249027578753 no 2590 0.246285637762835 3664 17646060
SGTC_3144 9087057 49.47 µM -0.686880520079737 0.231036476600122 no 2591 0.246079011704308 3584 17249618
SGTC_3349 9149703 23.001 µM -0.687146666034928 0.230950218899137 no 2592 0.24599515474443 3643 4910494
SGTC_541 4513-1321 94 µM -0.687899079439669 0.230706459578517 no 2593 0.245758168163891 3638 747515
SGTC_508 roscovitine 141 µM -0.68852244881828 0.230504615554707 no 2594 0.24556191927862 3690 160355 A CDKinase inhibitor.
SGTC_419 nsc-638432 893 µM -0.688791532599794 0.230417518020885 no 2595 0.245477232454825 3653 368090
SGTC_906 1165-0455 526 µM -0.690953702002805 0.229718331314002 no 2596 0.244797318263787 3650 3252859
SGTC_664 1222-0054 14.9 µM -0.691284871212516 0.229611345241948 no 2597 0.244693268635271 3664 6813991
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.691966300062701 0.229391293658267 no 2598 0.244479246311717 3719 65057 A dermal irritant. YDR527W RBA50
SGTC_838 0109-0203 71.4 µM -0.692363377535704 0.229263121260511 no 2599 0.2443545792361 3671 759422
SGTC_2657 nystatin 74.44 µM -0.693219791779341 0.228986816568669 no 2600 0.244085814731233 3680 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2693 st077581 40.7 µM -0.694071903172692 0.22871208563671 no 2601 0.243818558883209 3697 25238761
SGTC_47 0149-0135 24.25 µM -0.694506700250847 0.228571973184983 no 2602 0.243682250194893 3636 5239155
SGTC_1041 0206-0046 107 µM -0.695125805337025 0.228372551084999 no 2603 0.243488232052556 3679 50494
SGTC_3076 9116187 49.47 µM -0.69591484775133 0.228118531653496 no 2604 0.243241079129305 3628 27241210
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.697585573712974 0.227581193202903 no 2605 0.242718203048189 3633 641818 YHR062C RPP1
SGTC_1424 4048-1941 275 µM -0.703747374229858 0.22560560995982 no 2606 0.240795055995536 3756 X1424
SGTC_2557 derrustone 83.84 µM -0.703772641652991 0.225597528802454 no 2607 0.240787186937732 3677 629853 An antioxidant.
SGTC_2344 7990960 76.95 µM -0.705917385097813 0.224912183225794 no 2608 0.240119757721218 3672 140813
SGTC_998 3996-0085 177 µM -0.706305873365903 0.224788169472262 no 2609 0.239998970847471 3720 715391
SGTC_9 0092-0002 10.449 µM -0.70679487371151 0.224632125248921 no 2610 0.239846980359026 3664 759368
SGTC_1764 st044502 93.5 µM -0.708376778292317 0.224127746992359 no 2611 0.239355654586746 3701 8407
SGTC_2238 6671620 73.2395 µM -0.709284208656879 0.223838710267669 no 2612 0.239074062944192 3657 729941
SGTC_1720 st037298 9.481 µM -0.709734274568994 0.223695432910407 no 2613 0.238934466764473 3700 597396
SGTC_2890 9046729 58.44 µM -0.709824961201654 0.223666569360934 no 2614 0.238906344041953 3636 903329
SGTC_2806 7952793 58.44 µM -0.711131669904708 0.223250908040528 no 2615 0.238501323199985 3706 2972490
SGTC_2553 4-methylesculetin 85.09 µM -0.712666686311667 0.222763184609241 no 2616 0.238026017798933 3732 5319502
SGTC_1982 st072467 71.9 µM -0.713484285311615 0.222503655494663 no 2617 0.237773066968136 3682 3163533
SGTC_1837 st055472 66.5 µM -0.714981085288776 0.222028975768903 no 2618 0.237310365524288 3757 676091
SGTC_3264 9137442 49.47 µM -0.716121110835499 0.221667827992076 no 2619 0.236958284721037 3723 17015726
SGTC_288 1315-0019 35.1 µM -0.717743727884441 0.221154379781167 no 2620 0.236457657900875 3756 6811474
SGTC_3130 9127414 49.47 µM -0.717863722147287 0.221116436776981 no 2621 0.236420659144348 3706 1494646
SGTC_3248 9135562 49.47 µM -0.718052671277255 0.221056697324755 no 2622 0.23636240546209 3727 17650701
SGTC_460 trequinsin 123 µM -0.720292951662046 0.220349099240278 no 2623 0.235672321752656 3751 5537 A vasodilator.
SGTC_281 1672-3440 14.9 µM -0.722150869452919 0.219763257529273 no 2624 0.235100862862158 3731 6833000
SGTC_94 0334-0113 514.748 µM -0.723102926773334 0.219463400074063 no 2625 0.234808325651265 3695 6795178
SGTC_3350 9150499 3.57 µM -0.724400931374825 0.219054962905463 no 2626 0.234409814114508 3696 4910996 YPR165W RHO1
SGTC_2572 astragaloside iv 100 µM -0.72466592317925 0.218971632908939 no 2627 0.234328502731382 3724 45006101 An anti-inflammatory agent.
SGTC_6 0844-0013 19.835 µM -0.724886031458584 0.218902430964014 no 2628 0.234260975498863 3808 1584900
SGTC_3200 9114385 49.47 µM -0.725070317676543 0.218844501137046 no 2629 0.234204446437251 3700 17018030 YLR208W SEC13
SGTC_839 0122-0028 230 µM -0.725520973276375 0.21870287604787 no 2630 0.234066241451482 3736 759448
SGTC_2555 cholic acid 100 µM -0.727213601734743 0.218171414270702 no 2631 0.233547557576905 3752 6708657 Influences liver metabolism.
SGTC_2134 5324836 1.464 µM -0.72775905253003 0.218000309011134 no 2632 0.233380547210803 3706 699272
SGTC_1000 4048-0884 8.67 µM -0.728215757743114 0.217857102336971 no 2633 0.233240760639808 3701 13040088
SGTC_2893 9048488 25.97 µM -0.728443908676031 0.217785582564433 no 2634 0.233170946491348 3711 6467338
SGTC_2865 9030313 51.95 µM -0.73087436836846 0.217024533588865 no 2635 0.232427946662197 3665 42562754
SGTC_2150 5556613 200 µM -0.731857702857851 0.216717059638357 no 2636 0.232127712519665 3726 743190
SGTC_3147 9097027 49.47 µM -0.734073666711526 0.21602508527265 no 2637 0.231451920908648 3751 25236841
SGTC_947 3447-0010 211 µM -0.734936766290149 0.21575591370925 no 2638 0.23118900281124 3722 748350
SGTC_903 1134-0042 114 µM -0.73655095367945 0.21525302540378 no 2639 0.230697735280882 3731 701009
SGTC_1914 st062367 72.6 µM -0.737486676719543 0.214961819449685 no 2640 0.23041322123621 3738 978205
SGTC_1003 4049-0218 100 µM -0.737497635686663 0.21495841027041 no 2641 0.230409890237531 3738 295161
SGTC_750 4073-0104 132 µM -0.737687098829653 0.214899475937433 no 2642 0.230352306814855 3606 22330957
SGTC_2934 9036370 36.88 µM -0.738979366003441 0.214497754191994 no 2643 0.229959763491965 3752 6462800
SGTC_2347 9049783 174.81 µM -0.739695326726629 0.214275374532427 no 2644 0.229742442190402 3723 6467988 YPL169C MEX67
SGTC_2751 anetholtrithion 17.25 µM -0.739836484134279 0.214231546428948 no 2645 0.22969960912746 3741 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1762 st045503 25.4615 µM -0.741788178865589 0.213626097563814 no 2646 0.229107841931763 3809 4645554
SGTC_2088 5278280 127.392 µM -0.741801541434844 0.213621955706796 no 2647 0.229103793258984 3803 791502
SGTC_1807 st050092 58.9 µM -0.742112981228343 0.213525435197031 no 2648 0.22900944269811 3743 5008496
SGTC_2597 laccaic acid a 100 µM -0.742596039066298 0.21337577761476 no 2649 0.228863143658005 3748 5491415 A textile dye.
SGTC_2495 cafestol 54.53 µM -0.743268139004211 0.213167654096449 no 2650 0.228659678564292 3729 16667697 An anti-infammatory.
SGTC_800 3448-7362 155 µM -0.7432681862252 0.213167639478084 no 2651 0.228659664272632 3829 15991913
SGTC_3194 9111903 49.47 µM -0.743375097028204 0.21313454423101 no 2652 0.228627308488446 3732 17087251
SGTC_641 4092-0595 30 µM -0.744181234573424 0.212885093269145 no 2653 0.228383419573669 3789 786260
SGTC_1020 4335-0961 93.3 µM -0.744511077577915 0.212783075891151 no 2654 0.228283671009433 3700 669075
SGTC_2269 7935389 174.42 µM -0.744764590810238 0.212704686003479 no 2655 0.228207022149332 3720 97605
SGTC_1885 st057546 99.9 µM -0.744911367753845 0.212659308198839 no 2656 0.228162651255833 3819 702008
SGTC_3098 9119039 49.47 µM -0.745708442757579 0.21241298188522 no 2657 0.22792177898185 3742 17161528
SGTC_1064 honokiol 6.76 µM -0.746665855378886 0.212117325681638 no 2658 0.227632642659965 3758 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_208 k072-0098 12.366 µM -0.747685255373756 0.211802791952006 no 2659 0.227325013421923 3748 5948901
SGTC_120 rhodamine 6G 52.259 µM -0.74841206372524 0.211578703503819 no 2660 0.227105824089971 3790 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2360 9040895 200 µM -0.749329286465952 0.211296104979586 no 2661 0.226829380122346 3767 4914414
SGTC_1071 trifluoperazine 6.31 µM -0.749912346183729 0.211116577899127 no 2662 0.22665374908964 3840 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3285 9112818 20.8695 µM -0.750110660718132 0.211055536215719 no 2663 0.226594029675274 3770 17017947 YPR165W RHO1
SGTC_2775 cyproheptadine 69.59 µM -0.750288230692902 0.211000888536546 no 2664 0.226540564708255 3750 2913 A selective serotonin reuptake inhibitor.
SGTC_1783 st039459 87.517 µM -0.752879980088546 0.210204214619633 no 2665 0.225761019736204 3858 729761
SGTC_174 3553-0389 74.3 µM -0.755512318343819 0.209396875374218 no 2666 0.224970821988895 3746 738071
SGTC_1156 4092-0367 4.88 µM -0.756118644219382 0.209211173843356 no 2667 0.22478903228801 3792 1357585
SGTC_2461 5755302 26.15 µM -0.756530568557388 0.209085067671318 no 2668 0.224665575932673 3745 2788904
SGTC_1131 3454-3128 32.3 µM -0.757149966591057 0.208895529955156 no 2669 0.224480010796722 3850 710982
SGTC_509 pifithrin 175 µM -0.759316516134822 0.208233355809796 no 2670 0.223831619952926 3800 4817 A p53 inhibitor.
SGTC_2082 5219693 150 µM -0.76038153266843 0.207908303653927 no 2671 0.223513279384556 3764 2834649
SGTC_2783 7738165 71.43 µM -0.761569987675933 0.207545930964236 no 2672 0.223158346463169 3770 17201110
SGTC_171 k064-0041 9.68 µM -0.761972286519013 0.207423350338289 no 2673 0.223038272365296 3764 53325
SGTC_1874 staurosporine 7.6 µM -0.763659258524532 0.206909795470048 no 2674 0.222535162808074 3811 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_100 0086-0128 49.5915 µM -0.764579100356628 0.206630090798827 no 2675 0.222261109093556 3791 93297
SGTC_735 3076-0345 636 µM -0.765346564376241 0.206396892481756 no 2676 0.222032601603842 3814 2888990
SGTC_1497 4476-2978 41.3 µM -0.76557349183331 0.206327969164573 no 2677 0.221965061109605 3794 1528379
SGTC_2009 4012297 12.05 µM -0.766828683937745 0.20594698363604 no 2678 0.221591689835597 3792 45595307
SGTC_284 0988-0104 32.6 µM -0.768582823806281 0.205415253289297 no 2679 0.221070502647059 3778 4666532
SGTC_2403 6032726 181.2 µM -0.76903819286043 0.205277351221106 no 2680 0.220935318910777 3839 2881040
SGTC_1857 st056007 79.3 µM -0.769191405442492 0.205230965328848 no 2681 0.220889845896302 3779 619834
SGTC_3028 9087778 49.47 µM -0.771284874501888 0.204597780981802 no 2682 0.220269047862061 3772 17217395
SGTC_559 1550-0661 158 µM -0.771573373310022 0.204510613720066 no 2683 0.22018357482472 3837 5830875
SGTC_2857 9024691 58.44 µM -0.77315834701839 0.204032122866255 no 2684 0.219714336867154 3865 16478292
SGTC_3165 9101544 49.47 µM -0.775459267927856 0.203338681466789 no 2685 0.219034162606508 3806 5002184
SGTC_2655 perillic acid 100 µM -0.776940877032934 0.202892905921508 no 2686 0.218596826438087 3826 5702197 An apoptosis inducer.
SGTC_87 0100-0052 35.5 µM -0.77730682553957 0.202782892014087 no 2687 0.218488884512579 3866 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_983 1491-0821 12.2 µM -0.777558643513695 0.202707209501676 no 2688 0.21841462490688 3785 46495113
SGTC_2560 caryophyllene 100 µM -0.778657137809544 0.202377260524742 no 2689 0.218090855614584 3851 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_599 1935-0052 86.5 µM -0.780788572308782 0.201737969606557 no 2690 0.217463428173188 3796 9557311
SGTC_2825 7998094 58.44 µM -0.780891494678421 0.201707130269669 no 2691 0.217433157453484 3802 2987815
SGTC_2289 7946404 165.07 µM -0.782649196969447 0.201180893836325 no 2692 0.216916571495558 3830 1246120 YPR165W RHO1
SGTC_1096 rimcazole 32.2 µM -0.786677193287524 0.199978065823118 no 2693 0.215735429098933 3739 18528119 A dopamine reuptake inhibitor.
SGTC_337 1315-0038 354 µM -0.786916032022814 0.199906880585081 no 2694 0.215665510926887 3782 1626437
SGTC_1868 st057644 42.7 µM -0.791834249467708 0.198444409319226 no 2695 0.214228664562227 3824 688665
SGTC_533 1222-0222 6.71 µM -0.794817929849124 0.19756034248362 no 2696 0.213359709830225 3911 3982874
SGTC_2051 5263410 176 µM -0.794992674186898 0.197508639511673 no 2697 0.213308881787447 3865 227584
SGTC_1952 st077036 64.1 µM -0.798688066057779 0.196417171842 no 2698 0.212235654168365 3818 2937007
SGTC_2959 9079155 11 µM -0.800643657309025 0.195841052234494 no 2699 0.211668984509804 3844 16189457
SGTC_1814 st052110 31.539 µM -0.802089313664696 0.195415820044291 no 2700 0.211250648050043 3770 674163
SGTC_1641 st009299 47.1 µM -0.804358275403957 0.194749548872857 no 2701 0.210595045470897 3759 4046054
SGTC_324 1315-0088 19.6 µM -0.805065788614101 0.194542073527838 no 2702 0.210390858309076 3800 6787421
SGTC_2727 riluzole 51.77 µM -0.806626067821804 0.194085003730196 no 2703 0.209940975256987 3851 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_176 1486-1328 72.834 µM -0.807802916954757 0.193740689524712 no 2704 0.209602022835455 3904 22310231
SGTC_2316 5844804 197.44 µM -0.807985106745893 0.193687419031004 no 2705 0.209549577885285 3901 776813
SGTC_97 0535-0701 19.132 µM -0.809561762021764 0.193226793774408 no 2706 0.20909604618656 3763 2832013 YGL099W LSG1
SGTC_583 1488-1091 88.9 µM -0.810417274800884 0.192977132845839 no 2707 0.208850196338174 3949 4303273
SGTC_2701 st077767 14.721 µM -0.810562949128306 0.192934640916238 no 2708 0.208808350688054 3844 5721188
SGTC_190 3970-0790 3.722 µM -0.811718657755625 0.192597733337941 no 2709 0.208476542945919 3762 2832352
SGTC_2362 9071156 126 µM -0.812998430253412 0.192225078996227 no 2710 0.2081094790829 3865 653133
SGTC_44 0929-0055 61.211 µM -0.813024669201149 0.192217443147685 no 2711 0.208101957230491 3802 1379590
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.813449410246125 0.192093864221216 no 2712 0.207980220118486 3860 364106
SGTC_1196 1588-0294 184 µM -0.813521542471604 0.19207288209201 no 2713 0.207959550125045 3870 6144269
SGTC_2761 levamisole 97.89 µM -0.814116091800394 0.191899990471782 no 2714 0.207789224062291 3807 26879 An alkaline phosphatase inhibitor.
SGTC_92 0063-0024 660.874 µM -0.815371650478489 0.191535194167325 no 2715 0.207429803361361 3930 3594437
SGTC_1518 st038567 90.8 µM -0.817726337358937 0.190852198088724 no 2716 0.206756734059947 3828 77966
SGTC_1662 st014054 52 µM -0.817764717134614 0.190841078113219 no 2717 0.206745774213853 3867 2838777
SGTC_2377 9073351 62.6 µM -0.81996855698801 0.190203214862274 no 2718 0.20611701610299 3839 7337946 YHR072W ERG7
SGTC_1232 0279-0259 161 µM -0.820503937727122 0.190048456168462 no 2719 0.20596444269138 3864 1560000
SGTC_304 1310-0298 97 µM -0.82258995786457 0.189446203754489 no 2720 0.20537060561279 3773 1550234
SGTC_64 000l-0018 272.079 µM -0.828629320512161 0.187709219462491 no 2721 0.203657095731145 3810 6811119
SGTC_2892 9047358 58.44 µM -0.829417905387825 0.187483142524287 no 2722 0.203433986511485 3866 6466771
SGTC_365 0121-0052 13.6 µM -0.830432033059219 0.187192652900225 no 2723 0.203147280365088 3913 3101739
SGTC_2791 5663188 71.43 µM -0.831556553801251 0.186870867601346 no 2724 0.202829646958147 3893 54690634
SGTC_405 ebelactone b 50 µM -0.832830875369305 0.186506630327495 no 2725 0.202470059484025 3852 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2962 9082311 13.18 µM -0.835280298277097 0.185807751573225 no 2726 0.20177995379545 3882 16459453
SGTC_2831 7999036 19.48 µM -0.840135192372009 0.184427342668632 no 2727 0.20041629506773 3963 2988270
SGTC_2677 mitomycin C 100 µM -0.841903321128698 0.183926193371517 no 2728 0.199921035601081 3909 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_732 3970-1727 52.7 µM -0.842333633289627 0.183804356338778 no 2729 0.199800615002756 3938 1275699
SGTC_1759 st043059 70 µM -0.842843755364327 0.183659987355154 no 2730 0.199657916551828 3899 669426
SGTC_1005 4092-0690 4.4 µM -0.842968442924672 0.183624710439663 no 2731 0.199623046539589 3927 1529343
SGTC_1326 1431-2094 10.8 µM -0.843299946235833 0.183530941233659 no 2732 0.199530356443511 3878 616278
SGTC_3320 9137005 35.139 µM -0.846437114397216 0.182645038325587 no 2733 0.198654470618915 3924 4908713
SGTC_578 3460-0051 92 µM -0.847472320534227 0.182353294043367 no 2734 0.198365954441237 3962 2876744
SGTC_579 4491-1009 110 µM -0.848399294034888 0.18209229938848 no 2735 0.198107817849766 4027 1271041
SGTC_1515 3460-0031 42.1 µM -0.848405182880584 0.182090642097366 no 2736 0.198106178617029 3834 2876596
SGTC_2499 avocadenofuran 51.48 µM -0.848884498198212 0.181955780555911 no 2737 0.197972782757443 3889 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_890 0929-0006 47.2 µM -0.849655188025978 0.181739068035712 no 2738 0.197758409686216 3875 1378169
SGTC_2813 7971799 71.43 µM -0.849997828007927 0.181642771976504 no 2739 0.197663146904219 3970 2234054
SGTC_3243 9134147 49.47 µM -0.850089877122099 0.181616907795923 no 2740 0.197637559595501 3946 24282180
SGTC_625 k213-0058 121 µM -0.850668109088112 0.181454487508018 no 2741 0.197476871633459 3973 3655420
SGTC_796 1234-0020 70.7 µM -0.850818317122935 0.181412310271255 no 2742 0.197435142451498 3823 46495034
SGTC_1985 st071382 65.5 µM -0.851997694194099 0.181081363765722 no 2743 0.197107685917033 3905 6123237
SGTC_1447 4239-0816 81.9 µM -0.852040034446069 0.181069489651056 no 2744 0.197095936171178 3906 1341554
SGTC_1189 1431-2119 7.28 µM -0.852553674073222 0.180925480809321 no 2745 0.196953430983334 3920 3107275
SGTC_3104 9120930 49.47 µM -0.853162984823718 0.180754741816406 no 2746 0.196784463515456 3937 17014836
SGTC_2601 securinine 100 µM -0.853602300925863 0.180631700840596 no 2747 0.196662691605854 3868 442872 A GABA receptor antagonist.
SGTC_201 4262-0159 12.803 µM -0.856220136770498 0.17989960272546 no 2748 0.195938013158331 3942 1341029
SGTC_351 caspofungin 25 nM -0.856714513182863 0.1797615560072 no 2749 0.195801340252817 3915 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2115 tiliquinol 12.7705 µM -0.856931275795328 0.179701049501139 no 2750 0.195741433362252 3905 71208 A bioactive hydroxyquinoline.
SGTC_1153 4055-0057 267 µM -0.858301039399111 0.179318993520391 no 2751 0.195363127827855 3952 882706
SGTC_2227 7312221 64.1025 µM -0.86026976532092 0.178770769668192 no 2752 0.194820177631941 3964 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1964 st076914 61 µM -0.863017942724917 0.178007261371199 no 2753 0.19406380093466 3956 24208661
SGTC_1080 nisoldipine 24.4 µM -0.865778487858198 0.177242390293275 no 2754 0.193305824193651 3915 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1257 0669-0121 16 µM -0.86586368829032 0.177218816664674 no 2755 0.19328245906005 3940 4307855
SGTC_905 2-aminofluorene 215 µM -0.866872734710028 0.176939779896985 no 2756 0.193005872025928 3929 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3286 9117135 37.221 µM -0.872332301846139 0.17543483689065 no 2757 0.191513560314793 3908 3438150
SGTC_1933 st074711 15.9 µM -0.87255092771442 0.175374741590198 no 2758 0.191453948953262 3912 17250958
SGTC_2396 5342950 42.78 µM -0.87501789016055 0.174697534205183 no 2759 0.190782085783006 3939 1886677
SGTC_505 gw-5074 63.9 µM -0.875110723092577 0.174672083034643 no 2760 0.190756831540941 3988 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_866 0495-0101 262 µM -0.875894178376898 0.17445738392015 no 2761 0.190543782329497 3888 635694
SGTC_720 r052-1644 49.9 µM -0.876520868201538 0.174285765740944 no 2762 0.190373468401099 3956 1422863 YOR257W CDC31
SGTC_1259 0671-0132 43 µM -0.877280480300607 0.174077890841573 no 2763 0.190167155908857 3865 X1259
SGTC_1108 betulinic acid 729.144 nM -0.87894145771561 0.173623898325873 no 2764 0.189716509274829 3945 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1484 3473-2379 286 µM -0.88002816414304 0.173327278515142 no 2765 0.189422026219602 4048 671917
SGTC_1898 st060199 18.6 µM -0.883124483753691 0.172483899179904 no 2766 0.188584508490035 3918 688866
SGTC_2305 7443522 69.23 µM -0.883627954417381 0.172347011017168 no 2767 0.188448541771661 3865 5415886
SGTC_2107 5363541 170.161 µM -0.884720983795615 0.172050066922506 no 2768 0.188153567665617 3937 244052
SGTC_332 4112-0506 40.9 µM -0.885763384971817 0.171767181460008 no 2769 0.187872522117634 3923 2790355
SGTC_2818 7996756 12.99 µM -0.886286613847713 0.171625300340305 no 2770 0.18773155025649 3960 2241621
SGTC_2864 9034755 47.6 µM -0.888189812831091 0.171109851973008 no 2771 0.187219328814258 3913 4930451
SGTC_2104 5389443 200 µM -0.888447505441838 0.171040136589643 no 2772 0.1871500406647 4020 2244536
SGTC_2266 7929956 200 µM -0.888994915372967 0.17089210225503 no 2773 0.187002906227435 3905 2967153
SGTC_2450 5739737 12.93 µM -0.889738976904284 0.170691019535778 no 2774 0.186803029979577 4003 2262825
SGTC_3258 9138477 49.47 µM -0.890429268140878 0.170504603733444 no 2775 0.186617716258094 3993 4970355
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.890546813413769 0.170472873175267 no 2776 0.186586171716943 3956 77254
SGTC_1062 mesoridazine 14.2 µM -0.892733868724254 0.169883182082539 no 2777 0.185999854195696 3969 4078 A neuroleptic.
SGTC_1417 3966-0327 90.4 µM -0.89334917978645 0.169717513081141 no 2778 0.185835104419702 4035 651118
SGTC_655 k060-0012 42 µM -0.895387877359161 0.169169346073785 no 2779 0.185289889351221 3959 5994525
SGTC_236 1509-0011 5.31 µM -0.896331478998341 0.168916014823079 no 2780 0.185037875698713 4018 3107280
SGTC_1482 3346-2049 8.48 µM -0.896342308471724 0.16891310882071 no 2781 0.185034984639377 3963 3826804
SGTC_575 k072-0246 11.9 µM -0.897480595883667 0.168607837631423 no 2782 0.184731261511958 3990 6796779
SGTC_722 3534-0461 190 µM -0.901211154210491 0.16760984677238 no 2783 0.183738030734466 4026 658262
SGTC_116 0155-0182 31.788 µM -0.901282449359866 0.167590811175666 no 2784 0.183719081436924 3888 771486
SGTC_986 1493-0483 84 µM -0.903026808637292 0.16712550621719 no 2785 0.183255833437385 3892 40079
SGTC_165 k038-0023 64.381 µM -0.903116037461412 0.16710172698985 no 2786 0.183232156615338 3990 46368543
SGTC_2922 7999257 32.47 µM -0.904221202436329 0.166807384525667 no 2787 0.18293905983245 3936 2988377
SGTC_2152 5568786 200 µM -0.904560588459685 0.166717061828213 no 2788 0.182849111250848 3933 5399883
SGTC_721 1187-1332 279 µM -0.905292429933256 0.166522400190703 no 2789 0.182655242886672 3913 25730
SGTC_2321 7390090 138.78 µM -0.906558589580817 0.166185962555008 no 2790 0.182320134293213 4004 649046
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.907311593978319 0.165986086333295 no 2791 0.18212102240879 3974 75037 A free radical scavenger.
SGTC_2343 7990716 14.84 µM -0.910570429354143 0.165122858363572 no 2792 0.181260878533257 3991 6456862
SGTC_584 0986-0246 15.4 µM -0.916211355104408 0.163635523798697 no 2793 0.179778025468914 4080 53315 YDR232W HEM1
SGTC_172 1112-0046 2.638 µM -0.916457162622049 0.163570910477433 no 2794 0.179713582797683 3960 2802135 YIL048W NEO1
SGTC_1638 st008370 60.6 µM -0.919310846287546 0.162821999846353 no 2795 0.178966503119682 3961 24207134
SGTC_2308 7584454 197.62 µM -0.92025881117638 0.162573713475497 no 2796 0.178718763850317 4043 893577
SGTC_3132 9126706 49.47 µM -0.922423577542713 0.162007652419287 no 2797 0.178153838070279 4076 850858
SGTC_2235 salicylic acid 500 µM -0.923164570302141 0.161814186773556 no 2798 0.177960724615292 4017 338 A COX inhibitor and kinase inhibitor.
SGTC_2023 5144124 124 µM -0.924412939471 0.161488590923483 no 2799 0.17763568016633 3986 2830192
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.925827465348281 0.161120175194854 no 2800 0.177267825678968 4011 165521
SGTC_1719 st032227 49.2 µM -0.926890935710194 0.160843553926125 no 2801 0.176991581952842 4008 3125804
SGTC_2777 climbazole 1.536 µM -0.927968898012187 0.160563479744266 no 2802 0.176711851599548 3896 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1265 0819-1001 68.8 µM -0.928625247791275 0.1603931042837 no 2803 0.176541666343834 3969 3106768
SGTC_1294 1000-1494 117 µM -0.929332016085862 0.160209773313572 no 2804 0.176358523998031 3995 712797 YDL207W GLE1
SGTC_1361 1608-0041 5.61 µM -0.930070230468168 0.160018431751507 no 2805 0.176167361537013 3976 X1361
SGTC_2730 imipramine 71.33 µM -0.930226526137982 0.159977939853979 no 2806 0.176126905212038 3985 3696 A tricyclic antidepressant.
SGTC_2180 6301957 200 µM -0.931609468399343 0.159619949635409 no 2807 0.175769194039806 4016 845462
SGTC_2267 7931562 200 µM -0.933356689193858 0.159168411982386 no 2808 0.175317917288221 3921 934880
SGTC_1066 ketoconazole 628 nM -0.934361446609873 0.158909129857139 no 2809 0.175058738922264 4072 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_801 0866-0028 10.1 µM -0.93455699448822 0.158858700052207 no 2810 0.175008325386759 3996 6849771
SGTC_2595 hexamethylquercetagetin 100 µM -0.937061914516842 0.158213634577593 no 2811 0.17436335535389 3992 386331
SGTC_25 0118-0223 35.662 µM -0.937330920681578 0.158144462630172 no 2812 0.174294181206484 3998 5333628
SGTC_1947 st076332 61.6 µM -0.938678670471973 0.157798202627602 no 2813 0.17394787387633 3928 24208416
SGTC_1986 st071812 45 µM -0.939230962723783 0.1576564532301 no 2814 0.173806087612505 3942 11838594
SGTC_1325 1431-0015 227 µM -0.939839697883659 0.157500314336777 no 2815 0.173649896327408 4010 1103340
SGTC_1403 3909-7815 62.9 µM -0.942034939222261 0.156938085279952 no 2816 0.173087376043467 3970 6615483
SGTC_1104 tacrolimus 29.8 µM -0.943299378082548 0.156614846528688 no 2817 0.172763896949473 4052 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1442 4112-3290 3 µM -0.943567354686651 0.156546397822927 no 2818 0.172695390500485 3987 704353
SGTC_2407 paclitaxel 400 µM -0.944085987059135 0.156413980591553 no 2819 0.172562854757525 4175 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1357 1503-1303 39.5 µM -0.944615579107353 0.156278841275618 no 2820 0.172427585234554 3987 292895
SGTC_1262 0737-0114 49.6 µM -0.94660446571749 0.155772011637702 no 2821 0.171920183756143 4108 765919
SGTC_2236 dapsone 200 µM -0.947736214925584 0.155484091424387 no 2822 0.171631879801659 4020 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2932 9016711 44.54 µM -0.948276053518535 0.155346878711593 no 2823 0.171494469157768 4054 7117328
SGTC_3197 9113331 49.47 µM -0.94838868770242 0.155318260155581 no 2824 0.171465808092791 4053 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3276 9139060 49.47 µM -0.951212167864837 0.154601995608363 no 2825 0.170748341410175 4109 4870619
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.953003903217516 0.154148599556116 no 2826 0.170294046532003 4131 688801
SGTC_2067 5224629 34.075 µM -0.953455825414746 0.154034380331622 no 2827 0.170179583956977 4047 2835000
SGTC_3013 9080133 71.4286 µM -0.953589602467024 0.154000580142229 no 2828 0.170145710446432 4125 17050193
SGTC_1707 st032323 6.317 µM -0.954129104935908 0.153864318934081 no 2829 0.170009147590274 3918 3132057 YMR211W DML1
SGTC_1076 itraconazole 331 nM -0.954375221205303 0.153802184284026 no 2830 0.169946872162185 4032 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_98 0074-0023 107.663 µM -0.955053957894438 0.153630916112125 no 2831 0.169775205471561 4063 3563821
SGTC_1425 4048-4433 7.33 µM -0.955131275704083 0.153611414234492 no 2832 0.169755657239729 4069 23734946
SGTC_3169 9102970 49.47 µM -0.955293742223171 0.153570440632024 no 2833 0.169714585596311 4086 17027839
SGTC_3254 9136651 49.47 µM -0.955670046052833 0.153475565654168 no 2834 0.169619480218595 4022 16454030
SGTC_603 3794-0023 45.9 µM -0.955738827827102 0.15345822836093 no 2835 0.16960210031136 4071 3802260
SGTC_257 daunorubicin 18.5 µM -0.958978671525425 0.152643055468569 no 2836 0.168784744991075 4061 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_962 1254-0300 21.5 µM -0.961923658752829 0.151904567899987 no 2837 0.16804397662688 4021 7340576
SGTC_3072 9116419 49.47 µM -0.962357803734419 0.151795902406721 no 2838 0.167934951038535 4087 17170162
SGTC_1677 st019204 53.9 µM -0.963416084586686 0.151531233601409 no 2839 0.167669378806839 4066 3945625
SGTC_2025 5147754 141 µM -0.963451075763614 0.151522487790155 no 2840 0.167660602503588 4019 315777 YLR208W SEC13
SGTC_643 k048-0106 28.4 µM -0.964067112122045 0.151368568574864 no 2841 0.167506139956186 4057 6763920
SGTC_442 cape 100 µM -0.96608684562617 0.150864659387766 no 2842 0.167000363128195 4014 5281787
SGTC_2534 helenine 20.12 µM -0.966448690479513 0.150774499748802 no 2843 0.16690985494174 4044 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_8 0354-0001 70 µM -0.966697726421857 0.150712469163728 no 2844 0.166847582012061 4042 4993152
SGTC_2679 rapamycin 1 nM -0.967271376650661 0.150569647386229 no 2845 0.166704194368394 3997 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3283 9109332 35.8195 µM -0.96735935545059 0.150547751267615 no 2846 0.166682210524093 3886 17027281
SGTC_1358 1509-0022 2.48 µM -0.967604059091984 0.15048686070468 no 2847 0.166621074646343 4079 3258434
SGTC_835 0312-0010 67.2 µM -0.970499878917167 0.149767528477771 no 2848 0.165898692619002 4016 1626196
SGTC_741 4582-0002 126 µM -0.970833896252215 0.149684705136851 no 2849 0.165815500114291 4019 2912688
SGTC_899 1083-0020 478 µM -0.971688692642577 0.149472887985541 no 2850 0.165602721870445 4124 767123
SGTC_825 1988-2224 89.6 µM -0.97379319899091 0.148952247723464 no 2851 0.16507961531208 4038 1180859
SGTC_2261 9010538 184.68 µM -0.974921866607763 0.148673522929912 no 2852 0.164799509262731 4066 6457250
SGTC_3209 9113616 49.47 µM -0.976466470093502 0.148292648045206 no 2853 0.164416677963637 4122 16649353
SGTC_1852 st056254 31.4 µM -0.976675739982135 0.148241095640111 no 2854 0.164364854622069 3979 442583
SGTC_2661 dactinomycin 12.96 µM -0.977771494978914 0.147971358617645 no 2855 0.164093676097919 4040 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1766 st045414 44.774 µM -0.977824323524992 0.147958362361479 no 2856 0.164080609374764 4088 253960
SGTC_2513 baicalein 25.65 µM -0.978815633938148 0.147714633547817 no 2857 0.163835541749934 4074 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1763 st044482 94.5 µM -0.979645063750977 0.147510912266982 no 2858 0.163630676197992 4061 88505
SGTC_2183 6420625 130.508 µM -0.980256843600064 0.147360769990555 no 2859 0.163479675867658 4046 2897619
SGTC_2735 sertaconazole 140 nM -0.981447903091438 0.147068755472474 no 2860 0.163185956642577 4185 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2181 6316240 54.2555 µM -0.983743966230519 0.146506920545379 no 2861 0.162620708214359 4085 12779990
SGTC_919 tnp00227 403.569 nM -0.983757292112931 0.146503663980642 no 2862 0.162617431349902 4033 1269246 A methoxyflavone. YNL221C POP1
SGTC_1617 st002906 78 µM -0.983793505797815 0.146494814364922 no 2863 0.162608526540333 4063 5150859
SGTC_1222 0366-0074 1.18 µM -0.98446445007005 0.146330919186465 no 2864 0.162443601243434 4083 286520
SGTC_1775 st081588 35.1725 µM -0.984532171485972 0.14631438335409 no 2865 0.162426960643801 4076 1426443 YGL099W LSG1
SGTC_818 4072-2707 53.5 µM -0.984758171913197 0.146259208928671 no 2866 0.162371435536665 3986 882871
SGTC_3325 9138760 55.175 µM -0.985065271024733 0.146184257939155 no 2867 0.16229600543275 4008 43844959
SGTC_2591 skatole 100 µM -0.985076429723505 0.146181535019111 no 2868 0.162293265047454 4113 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1307 1187-1599 12.2 µM -0.985154411743448 0.146162506976605 no 2869 0.162274114839836 4052 1538471
SGTC_2157 5649910 96.377 µM -0.985418640176281 0.14609804615195 no 2870 0.162209238648655 4073 2858091
SGTC_264 promethazine 12.5 mM -0.985560393086575 0.146063472168352 no 2871 0.162174440918937 3970 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_228 caffeine 993.056 µM -0.9855771537495 0.14605938455301 no 2872 0.162170326806129 4077 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_124 0136-0217 7.121 µM -0.986909615158813 0.145734667783413 no 2873 0.161843475072992 4112 3976905
SGTC_531 3788-1495 174 µM -0.987585283112161 0.145570195138838 no 2874 0.161677898383932 4028 2896655
SGTC_1360 1598-0022 39.8 µM -0.989627115051492 0.145073926476134 no 2875 0.161178205814705 4128 761525
SGTC_1272 0839-0021 27 µM -0.990549702137833 0.144850064984083 no 2876 0.160952754167379 4092 5027250
SGTC_2446 5162541 200 µM -0.99091448134726 0.144761617193565 no 2877 0.160863670261102 4046 1549321
SGTC_1313 1220-0047 237 µM -0.991562914167604 0.144604481896369 no 2878 0.160705393873323 4053 3528706
SGTC_1017 4239-0030 168 µM -0.992157057884703 0.144460603437885 no 2879 0.160560458261314 4109 1149593
SGTC_1154 4088-0362 150 µM -0.993921757077319 0.144033830964218 no 2880 0.160130480556394 4073 6618304
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.995975577411759 0.143538209469587 no 2881 0.159631005851776 4018 97141
SGTC_3048 9093155 49.47 µM -0.996549119565642 0.143400009943755 no 2882 0.15949170673088 4049 25236002
SGTC_613 3914-0030 117 µM -0.997125200479933 0.143261289150078 no 2883 0.15935187113297 3808 1145395
SGTC_2234 tolnaftate 200 µM -0.99852395035639 0.142924846227398 no 2884 0.159012678326589 4101 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1728 st035614 33.7865 µM -0.998695823936764 0.142883542143683 no 2885 0.158971032139323 4058 15945546
SGTC_3326 9140064 16.379 µM -1.00221179779473 0.142040365474106 no 2886 0.158120655482474 4020 1868434
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.00297469222562 0.141857858988194 no 2887 0.157936536071352 4062 688803
SGTC_957 1187-1561 14.1 µM -1.00338266782828 0.141760324578851 no 2888 0.157838131711548 4055 1538454
SGTC_1027 k015-0025 8.67 µM -1.00492028343099 0.141393136243673 no 2889 0.157467618330521 4056 3598955
SGTC_884 0851-0618 334 µM -1.00576773358647 0.14119103776552 no 2890 0.157263656024302 4116 9642473
SGTC_3242 9133940 49.47 µM -1.00586439735354 0.141167998004223 no 2891 0.157240402257637 4118 17248444
SGTC_2070 5230947 200 µM -1.00696514563022 0.140905814987873 no 2892 0.156975761943109 4168 2835538
SGTC_1900 st060200 72.8 µM -1.00707587848084 0.140879458252378 no 2893 0.156949155940289 4085 688945
SGTC_3115 9123671 49.47 µM -1.0084263309186 0.140558291430372 no 2894 0.156624918762619 4208 3286988
SGTC_2694 st077685 81.9 µM -1.00996452318563 0.140193081898552 no 2895 0.156256143683339 4047 2838096
SGTC_78 0336-0123 156.75 µM -1.01048381973781 0.140069932152018 no 2896 0.156131773789485 3914 6765896
SGTC_1118 chelidonine 707.474 nM -1.01074854439399 0.140007181721865 no 2897 0.15606839817324 4096 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_698 k064-0052 127 µM -1.01193412620733 0.139726385338238 no 2898 0.155784775501342 4183 5088751
SGTC_348 k064-0012 10.7 µM -1.01210458692881 0.139686044466583 no 2899 0.155744024729703 4003 5066323
SGTC_2882 9058044 58.44 µM -1.01240056335036 0.139616018130191 no 2900 0.15567328455714 4144 18076804
SGTC_2099 5377090 177.372 µM -1.01260004638315 0.139568835048899 no 2901 0.155625618849726 4121 2243829
SGTC_1493 4348-0038 111 µM -1.01274277844458 0.139535081748685 no 2902 0.155591519478382 4075 800424
SGTC_2482 5981709 142.65 µM -1.01326839184733 0.13941083247644 no 2903 0.155465990419571 4052 877755
SGTC_2429 5902844 64.44 µM -1.01537586174946 0.138913405606065 no 2904 0.154963347411742 4117 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2928 9011484 9.79 µM -1.01670064184615 0.138601336627625 no 2905 0.154647930162058 4131 2994751
SGTC_3111 9122088 49.47 µM -1.01727696535688 0.138465725420048 no 2906 0.154510845664316 3950 16876704
SGTC_793 0488-0545 106 µM -1.01755007322004 0.138401493643974 no 2907 0.154445912197867 4125 292548
SGTC_2685 mycophenolic acid 18.85 µM -1.01768905629186 0.138368814248455 no 2908 0.154412874845284 4074 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_872 0588-0139 234 µM -1.02531375857125 0.13658405687821 no 2909 0.152607582964004 4069 2047100
SGTC_295 k015-0027 31 µM -1.02551159886219 0.136537957779971 no 2910 0.152560927689806 4150 3887424
SGTC_1667 st014849 34.6 µM -1.02598504797548 0.136427681813785 no 2911 0.152449315966346 4164 5348460
SGTC_1959 st077091 55.8 µM -1.02716805307747 0.136152402134127 no 2912 0.152170669191535 4110 821356 YKL052C ASK1
SGTC_3356 9151811 4.48 µM -1.02787370644511 0.13598838106964 no 2913 0.152004619676865 4117 1859254 YPR165W RHO1
SGTC_2479 5617353 43.85 µM -1.02881531384852 0.135769725947854 no 2914 0.151783234587349 4168 2731746
SGTC_2040 5100729 123 µM -1.03021809325328 0.135444426665872 no 2915 0.151453819049463 4146 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_768 0384-0033 77.3 µM -1.03225691351242 0.13497258487305 no 2916 0.150975889804327 4092 3965305 YMR134W ERG29
SGTC_1382 3002-2117 298 µM -1.03236909764025 0.134946654996254 no 2917 0.150949621372277 4202 1497314
SGTC_1844 rapamycin 4 nM -1.03255902291339 0.134902764071909 no 2918 0.150905156426448 4026 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1092 toremifene 6.32 µM -1.03346779869585 0.134692885385998 no 2919 0.150692516230719 4104 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_511 blebbistatin 171 µM -1.03539811992074 0.134247828026627 no 2920 0.150241511688976 4191 3476986 A myosin inhibitor.
SGTC_3116 9124943 49.47 µM -1.03577266044379 0.134161590612397 no 2921 0.150154107525384 4111 41905195 YPL160W CDC60
SGTC_1051 3253-3903 78 µM -1.03620293555653 0.134062567367407 no 2922 0.15005373877479 4110 5509239
SGTC_1633 st005664 67.9 µM -1.03758941799836 0.133743824826424 no 2923 0.149730623278352 4119 2063822
SGTC_1514 1189-1591 158 µM -1.03931179264941 0.133348589137466 no 2924 0.149329876049986 4148 767698 YMR146C TIF34
SGTC_326 k292-0812 17.5 µM -1.03988938034375 0.133216229382201 no 2925 0.149195648423925 4117 3579357
SGTC_1872 amphotericin b 148 nM -1.04448607876367 0.132166074607892 no 2926 0.148130278354502 4155 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_772 k072-0172 35.3 µM -1.04801815242426 0.131363030064667 no 2927 0.147315121798526 4173 5861980
SGTC_17 0960-0276 49.807 µM -1.05032071276046 0.130841342593734 no 2928 0.146785342653426 4120 6821114
SGTC_150 3970-0969 77.2 µM -1.05298615989284 0.130239226745296 no 2929 0.146173667635428 4227 6615640
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.05435575752751 0.129930585863729 no 2930 0.145860034950119 4185 688788
SGTC_3323 9138564 53.9225 µM -1.05494988695936 0.129796855499653 no 2931 0.145724122303504 4173 43912313 YNL103W MET4
SGTC_1182 1222-0449 220 µM -1.05530390271456 0.129717216752498 no 2932 0.14564317838881 4137 658318
SGTC_954 1189-0853 2.85 µM -1.05546728723871 0.129680473479372 no 2933 0.145605831539345 4090 2828194
SGTC_2714 st079313 56.9 µM -1.05801106065397 0.129109338192153 no 2934 0.145025199919032 4131 2939799
SGTC_3159 9100096 49.47 µM -1.06015026462926 0.128630389847704 no 2935 0.144538121746059 4085 25236875
SGTC_2232 chlorophetanol 41.5365 µM -1.06095297644775 0.128450988480533 no 2936 0.144355635944799 4224 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_235 0330-0087 5 mM -1.06184256760557 0.12825237307885 no 2937 0.144153580762522 4174 46494818 YHR062C RPP1
SGTC_198 3454-2873 16.191 µM -1.06262406746147 0.128078066830848 no 2938 0.14397623405342 4137 710957
SGTC_858 0438-0351 2.77 µM -1.0633865738485 0.127908155570506 no 2939 0.143803339446733 4125 2799119
SGTC_21 0849-0113 22.993 µM -1.06478017280308 0.127598021183826 no 2940 0.14348770976891 4127 1560156
SGTC_1902 st060212 70.5 µM -1.06693623642678 0.127119237121554 no 2941 0.143000315160771 4164 688944
SGTC_86 0417-1630 471.922 µM -1.06712055296519 0.127078365137218 no 2942 0.142958700968624 4162 3634867
SGTC_3318 9139014 38.6185 µM -1.06754100765899 0.126985164010433 no 2943 0.142863803151787 4158 16643984
SGTC_950 1165-0508 94.1 µM -1.06916097451775 0.126626514890085 no 2944 0.142498570142088 4181 6148369
SGTC_1709 st033179 39.1045 µM -1.07012739817894 0.126412891860776 no 2945 0.142280984084263 4146 573381
SGTC_173 1273-0061 2.693 µM -1.07231817273871 0.125929562434496 no 2946 0.141788573539657 4139 2847414 YPL266W DIM1
SGTC_3121 9125696 49.47 µM -1.07527483466503 0.125279308098636 no 2947 0.141125849787321 4275 1235365
SGTC_3168 9103419 49.47 µM -1.07644025876408 0.125023643322621 no 2948 0.140865202767222 4168 16649256
SGTC_1439 4092-1168 46 µM -1.07757983735557 0.124774001025536 no 2949 0.140610652082543 4174 2886240
SGTC_2376 9072922 81.32 µM -1.0778712755513 0.124710212958462 no 2950 0.140545602925801 4189 17087968
SGTC_1070 indatraline 8.81 µM -1.08023020573267 0.124194744665024 no 2951 0.140019840348585 4198 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_137 0438-0332 85.389 µM -1.08064209380905 0.124104892841094 no 2952 0.139928175224171 4129 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2085 5307070 144.047 µM -1.08106665434763 0.124012324179898 no 2953 0.139833732553944 4118 2840351
SGTC_341 1486-1430 230 µM -1.08576745789694 0.122990617275194 no 2954 0.138790943579381 4136 2054753 YPL210C SRP72
SGTC_1039 k821-0043 94 µM -1.08800297722153 0.12250680939583 no 2955 0.138296896603013 4193 15992768
SGTC_2182 6325192 200 µM -1.08944041782929 0.122196426848 no 2956 0.137979858022712 4154 736248
SGTC_1820 st053765 18.6 µM -1.0912294292326 0.121810902309192 no 2957 0.137585970723071 4241 3690829
SGTC_2268 7933382 153.85 µM -1.09155102955916 0.121741689486411 no 2958 0.137515245327947 4215 935025 YOR257W CDC31
SGTC_2646 retinol 96.75 µM -1.09262968938003 0.121509748812212 no 2959 0.137278210889032 4197 445354 A vitamin A analog and teratogen.
SGTC_1967 st070177 51.4 µM -1.09461479370414 0.121083710578649 no 2960 0.136842715833209 4228 5729214
SGTC_447 ml7 120 µM -1.09634562842284 0.120713101542586 no 2961 0.13646377422967 4217 4216 Selective myosin light chain kinase inhibitor.
SGTC_167 3672-0051 66.205 µM -1.09815710673306 0.120326080937958 no 2962 0.136067946239062 4102 3237971
SGTC_2471 5466956 24.79 µM -1.09877698967525 0.120193844492289 no 2963 0.135932675641398 4167 724419
SGTC_441 propafenone 146 µM -1.10094607108458 0.119731931650636 no 2964 0.135460064538293 4174 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3025 9087895 49.47 µM -1.10194497867752 0.119519632599069 no 2965 0.135242796318036 4186 17173641
SGTC_1511 0906-3109 28.5 µM -1.10315485491682 0.11926285190734 no 2966 0.134979961261958 4211 2882180
SGTC_2135 5326629 150.42 µM -1.10451663700675 0.118974297199392 no 2967 0.134684545334227 4155 5020077
SGTC_1778 st046819 58.9 µM -1.10729079327099 0.118387993534909 no 2968 0.134084111797349 4237 671715
SGTC_2304 7443016 91.4 µM -1.10940907598634 0.117941682655927 no 2969 0.133626874402225 4134 939854
SGTC_3160 9100216 49.47 µM -1.10997212950388 0.117823250787651 no 2970 0.133505518261494 4169 17191039
SGTC_1770 st043884 66.3 µM -1.11106118254076 0.11759441978153 no 2971 0.133271007452461 4203 670149
SGTC_1703 st026983 48.3 µM -1.11362382587256 0.117057200710929 no 2972 0.132720300310732 4227 1104023
SGTC_2838 9002687 71.43 µM -1.11414468113056 0.116948224336544 no 2973 0.132608561445133 4205 6457060
SGTC_2386 9075165 157.42 µM -1.11429642412139 0.116916489312383 no 2974 0.132576020277406 4184 16452277
SGTC_1865 st057639 52.2 µM -1.115895749955 0.116582382760011 no 2975 0.132233380625799 4192 688818
SGTC_1673 st016611 27.3 µM -1.11658082994919 0.116439473718673 no 2976 0.132086795969111 4227 5226799
SGTC_1892 st058411 7.36 µM -1.11936709116265 0.115859534669451 no 2977 0.131491782186909 4223 3934738
SGTC_1909 st060837 51.5 µM -1.11937248497755 0.11585841398067 no 2978 0.131490632120124 4187 678937
SGTC_2154 5570129 200 µM -1.12062688825253 0.115597991949715 no 2979 0.131223357386342 4261 673366
SGTC_1402 3909-7673 35.9 µM -1.12275937678839 0.115156228786771 no 2980 0.130769851305853 4214 5328014
SGTC_3174 9107204 49.47 µM -1.12290960871142 0.115125152284307 no 2981 0.130737943104529 4242 3938802
SGTC_91 0417-1751 58.384 µM -1.12395126461318 0.114909842626095 no 2982 0.130516850763983 4315 6795624
SGTC_573 3702-0553 84.7 µM -1.12403005483679 0.114893568392982 no 2983 0.130500137997481 4175 1222756
SGTC_638 3970-0837 4.09 µM -1.12610297530939 0.114465992555447 no 2984 0.130060967404986 4196 4118451 YLR208W SEC13
SGTC_1238 0333-0287 48.8 µM -1.13086497079491 0.113488041293096 no 2985 0.129055964445251 4197 7226
SGTC_2671 danthron 100 µM -1.13247873222002 0.11315798536169 no 2986 0.128716610404812 4219 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_367 0335-0881 7.1 µM -1.13345848873195 0.112957934269937 no 2987 0.128510882051453 4184 23828853
SGTC_1072 oxiconazole 14.9 nM -1.13469196767197 0.112706436119337 no 2988 0.128252201984397 4210 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_360 0957-0399 1.01 µM -1.13504850119941 0.112633815853097 no 2989 0.128177498665163 4233 6752301 YPR165W RHO1
SGTC_1029 k015-0030 64.7 µM -1.13871209724639 0.111889534413442 no 2990 0.127411627707076 4274 2208316
SGTC_2964 9083345 53.42 µM -1.13930733081666 0.111768942060774 no 2991 0.127287495921215 4218 17741579
SGTC_18 0111-0177 500 nM -1.14001676168074 0.111625335179003 no 2992 0.127139659007484 4307 721752
SGTC_520 3584-0023 682 µM -1.14028330860012 0.111571413423275 no 2993 0.127084144704322 4240 1340790
SGTC_2442 5158906 48.48 µM -1.14260163180248 0.111103208487538 no 2994 0.126602013866984 4240 1893835
SGTC_2185 6113692 200 µM -1.14316266328184 0.110990115200107 no 2995 0.126485530477172 4239 874150
SGTC_177 1327-0068 8.361 µM -1.14403129226247 0.110815178799642 no 2996 0.126305329902005 4221 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2706 st078239 82.5 µM -1.14487053486573 0.110646348354458 no 2997 0.126131395652497 4222 15434492
SGTC_2957 9076800 11.52 µM -1.14531076438366 0.110557861125269 no 2998 0.1260402242395 4210 16459615
SGTC_1574 spiramycin 23.7 µM -1.14554087264304 0.110511628984007 no 2999 0.125992587171116 4198 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1274 0865-0114 173 µM -1.14667474277995 0.110284020157717 no 3000 0.125758036442747 4226 870624
SGTC_2789 5281112 71.43 µM -1.14806887100833 0.110004629144575 no 3001 0.125470066809687 4255 765948
SGTC_3180 9109287 49.47 µM -1.1493041621621 0.109757494632425 no 3002 0.125215291223445 4287 18891271
SGTC_2300 7976697 71.57 µM -1.14953947515401 0.10971046272866 no 3003 0.125166799520142 4132 2236109
SGTC_451 chloral hydrate 100 µM -1.14969959337955 0.109678468242403 no 3004 0.125133810942076 4265 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3108 9121785 49.47 µM -1.14987206748257 0.109644012325189 no 3005 0.1250982835205 4059 17140271
SGTC_1296 1068-0102 11.9 µM -1.15054198719323 0.109510253209166 no 3006 0.124960355599055 4236 767053
SGTC_1870 st057514 26.5 µM -1.15079872064555 0.109459023750764 no 3007 0.124907525624362 4233 5393161
SGTC_2980 9014342 25.29 µM -1.15182388682276 0.109254630226207 no 3008 0.124696725032463 4307 2996599
SGTC_1618 st003135 44.5 µM -1.1531527824366 0.108990088647883 no 3009 0.124423840070682 4216 1270615
SGTC_979 1426-2828 121 µM -1.1553378683915 0.108556107832369 no 3010 0.123976047173407 4342 747872
SGTC_2365 9042475 200 µM -1.15539018573002 0.108545732323844 no 3011 0.123965339546465 4303 6464479
SGTC_546 peri-Naphthalide 147 µM -1.15843769454292 0.107942584737324 no 3012 0.123342731975282 4176 223824 A penicillin ester.
SGTC_3348 9149464 3.537 µM -1.16043057723431 0.107549470856123 no 3013 0.122936771735107 4197 1951442
SGTC_3093 9117344 49.47 µM -1.16143643782883 0.107351448117994 no 3014 0.122732228996576 4276 24824913
SGTC_1809 st050081 57.6 µM -1.16530028315829 0.106593221034142 no 3015 0.121948732271854 4331 5036894
SGTC_358 0075-0058 9.45 µM -1.16607452394461 0.106441752871711 no 3016 0.121792157944405 4121 1069125
SGTC_1839 st053978 48 µM -1.1668056494572 0.106298862265266 no 3017 0.121644432509425 4260 3788398
SGTC_3274 9138298 49.47 µM -1.16714889634477 0.106231826165794 no 3018 0.121575122213335 4242 17015756
SGTC_2214 7179297 48.276 µM -1.16902167636557 0.105866610092049 no 3019 0.121197449059197 4305 769744
SGTC_3263 9137018 49.47 µM -1.16951480163262 0.10577059546627 no 3020 0.121098140615831 4217 43844957
SGTC_2083 5306046 65.942 µM -1.17086925363988 0.105507198979582 no 3021 0.120825667750307 4253 539837
SGTC_3284 9108171 64.8615 µM -1.17297685542852 0.105098283489445 no 3022 0.120402543572709 4238 8687505
SGTC_279 1273-0055 2.93 µM -1.17322392670822 0.105050422100678 no 3023 0.120353009732292 4273 2847562
SGTC_3052 9092717 49.47 µM -1.17611689087013 0.104491185282605 no 3024 0.119774084560848 4273 25237534
SGTC_864 0469-0573 172 µM -1.1814977946448 0.103456749759574 no 3025 0.118702514511257 4245 689425
SGTC_2228 7354201 200 µM -1.18333270112731 0.103105708862184 no 3026 0.118338658793451 4342 753451
SGTC_2883 9059145 45.46 µM -1.18567004559714 0.102659799093292 no 3027 0.117876314180376 4266 16476510
SGTC_1013 4112-3890 241 µM -1.18572498005637 0.102649335789727 no 3028 0.117865463117944 4218 705171
SGTC_158 k038-0087 26.446 µM -1.18610502557649 0.10257697018502 no 3029 0.117790413061691 4181 X158
SGTC_2205 7238770 200 µM -1.18855924670616 0.102110547481503 no 3030 0.117306576339007 4334 279867
SGTC_2256 7954252 200 µM -1.1990160029694 0.100140540006967 no 3031 0.115260861549156 4283 2972920
SGTC_74 000s-0487 160.283 µM -1.20048392522384 0.0998662260367924 no 3032 0.114975725975085 4166 677548
SGTC_1478 0453-0656 35.7 µM -1.2017976877492 0.0996211860164873 no 3033 0.114720960775171 4282 5258496
SGTC_1160 4092-0570 10.5 µM -1.20300298644476 0.0993967631223406 no 3034 0.114487582437433 4275 4994975
SGTC_282 k297-0036 65.7 µM -1.20535485341066 0.09895991732909 no 3035 0.114033171071469 4290 5061378
SGTC_261 5-fluorouridine 15.376 µM -1.20660742221852 0.098727833870746 no 3036 0.113791683499007 4313 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3337 9144342 33.5465 µM -1.21271209027423 0.0976024245611119 no 3037 0.112619957872376 4291 17682949
SGTC_1519 esterone 74 µM -1.21467717954307 0.0972421650668963 no 3038 0.11224461979398 4262 698 A steroid.
SGTC_2793 7325131 81.82 µM -1.21769702074802 0.0966904414079987 no 3039 0.1116695648187 4242 4176441
SGTC_200 k038-0079 37.545 µM -1.21800243711304 0.0966347702524522 no 3040 0.111611523307527 4274 3436683
SGTC_2309 7664088 163.95 µM -1.21825297228286 0.0965891203975284 no 3041 0.111563927569274 4304 704922
SGTC_2153 5569715 200 µM -1.21989306710787 0.0962906709963892 no 3042 0.111252707168021 4343 2054701
SGTC_2071 5230951 39.92 µM -1.22010459246506 0.0962522289515508 no 3043 0.111212613926526 4348 1799272
SGTC_1711 st032263 62.8 µM -1.22315947196489 0.0956983007769236 no 3044 0.110634734828154 4307 3958979
SGTC_2441 5730946 39.09 µM -1.22553018058766 0.0952700493636685 no 3045 0.110187762966538 4359 1774275
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.22916286021185 0.0946165722130138 no 3046 0.109505375350692 4335 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2639 lactacystin 53 µM -1.23047194149079 0.0943818952906683 no 3047 0.109260213908799 4343 3870 A proteasome inhibitor.
SGTC_2589 lobaric acid 100 µM -1.23117448945221 0.0942561277619599 no 3048 0.109128805216555 4279 73157 A novel microtubule depolymerizer.
SGTC_1337 1486-1011 40.3 µM -1.23127428088095 0.0942382735015634 no 3049 0.109110148858192 4282 X1337
SGTC_2993 9054257 71.4286 µM -1.23516284971587 0.0935444883985015 no 3050 0.108384951206883 4234 6470217 YGL055W OLE1
SGTC_668 1682-0499 62.6 µM -1.23812465299584 0.0930185896563957 no 3051 0.107834922014213 4305 682214
SGTC_462 ag-879 158 µM -1.24002034436564 0.0926831390489568 no 3052 0.107483934690379 4346 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2790 5423970 71.43 µM -1.24025824433142 0.0926411049118669 no 3053 0.107439945716589 4359 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.24076121411034 0.0925522824668997 no 3054 0.107346986639505 4281 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2148 5546263 113.568 µM -1.24130460109176 0.0924563933211219 no 3055 0.107246622810484 4318 792097
SGTC_1547 harmine 94.2 µM -1.24241365692482 0.092260911197515 no 3056 0.107041989678068 4263 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_448 monastrol 171 µM -1.24318659976155 0.0921248533417333 no 3057 0.10689953975843 4246 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1166 k206-0078 225 µM -1.24375196260713 0.0920254290150506 no 3058 0.106795432543903 4342 5404595
SGTC_3047 9092122 49.47 µM -1.25324389518622 0.0903680305768899 no 3059 0.105058479835738 4294 17173831
SGTC_2940 9060638 45.86 µM -1.25387808416282 0.0902580891841802 no 3060 0.104943160988177 4317 4027022
SGTC_2329 6138490 200 µM -1.25428724742543 0.0901872104210705 no 3061 0.104868808729163 4384 720019
SGTC_2760 etidronate 98.04 µM -1.25645981258439 0.0898115525891886 no 3062 0.104474653789663 4289 3305 A chelator and antioxidant.
SGTC_2359 9039622 200 µM -1.256711892399 0.0897680409322848 no 3063 0.104428990109919 4293 6463596
SGTC_1843 st055809 45.5 µM -1.25970100574699 0.0892532822435417 no 3064 0.103888621221574 4391 16413835
SGTC_1483 3453-0561 55.9 µM -1.26181177212183 0.0888911099216246 no 3065 0.103508262576114 4367 4546991
SGTC_2019 4016004 108 µM -1.26300463713157 0.0886869186600659 no 3066 0.103293756615112 4366 45595336
SGTC_3113 9123498 49.47 µM -1.26417510522069 0.0884869009958025 no 3067 0.103083592054978 4441 8897275
SGTC_2581 avocatin a 64 µM -1.26617269741113 0.0881463152141556 no 3068 0.102725630033373 4292 6710728 A skin care supplement.
SGTC_2016 5121758 140 µM -1.26623157523049 0.0881362915017805 no 3069 0.102715093042776 4279 2795203
SGTC_2477 5967686 25.23 µM -1.26637049960964 0.088112643551952 no 3070 0.102690233739525 4318 776118
SGTC_1383 3049-0032 20.7 µM -1.26793910033439 0.0878459617556758 no 3071 0.10240984972944 4397 712864
SGTC_1526 st051518 75 µM -1.26922089598623 0.0876284877568698 no 3072 0.102181145148888 4324 673993
SGTC_303 1348-1668 34.2 µM -1.27370434717928 0.0868709692020745 no 3073 0.1013841076174 4350 5380509
SGTC_652 0437-0092 114 µM -1.27440588801611 0.0867528817132358 no 3074 0.101259803344992 4290 3091274
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.27483533385497 0.0866806540716726 no 3075 0.101183765722439 4416 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2431 5490079 200 µM -1.28219810079569 0.0854493061748975 no 3076 0.0998865811439228 4390 5722345
SGTC_2728 chlorpromazine 9.18 µM -1.2865329763294 0.0847304957815313 no 3077 0.0991285588975903 4429 2726 A thorazine and dopamine antagonist.
SGTC_356 1634-0012 32.5 µM -1.28825417274925 0.0844463475371194 no 3078 0.0988287499708159 4360 735457
SGTC_2345 9052315 157.45 µM -1.28883958792586 0.0843498658467216 no 3079 0.0987269300018245 4366 6469265
SGTC_1444 4112-3581 28 µM -1.29107603064938 0.0839820415015717 no 3080 0.09833865733476 4428 2877249
SGTC_3009 9080819 71.4286 µM -1.2929964517306 0.0836671550085509 no 3081 0.0980061431568584 4369 17027216
SGTC_429 1112-0049 25.5 µM -1.30290331153684 0.082056830108621 no 3082 0.0963038866191921 4350 2836170
SGTC_392 N-ethylmaleimide 8.33 µM -1.30763343733605 0.0812962505808582 no 3083 0.0954988349703976 4322 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_209 4077-0173 175.592 µM -1.30889913316201 0.0810936380521312 no 3084 0.0952842601506178 4361 15993494
SGTC_1171 0368-0077 21.4 µM -1.31269002814173 0.0804890716992819 no 3085 0.0946437095672027 4335 3239779
SGTC_2713 st079149 53.4 µM -1.31305112966217 0.0804316618494679 no 3086 0.0945828599194211 4403 3103253
SGTC_476 mead acid 10 µM -1.31347405605883 0.0803644620929714 no 3087 0.0945116287629178 4433 5312531 An omega 9 fatty acid.
SGTC_783 0848-0141 92.7 µM -1.31431629587255 0.080230763034352 no 3088 0.0943698927859726 4300 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2179 6298986 200 µM -1.31501071712753 0.0801206555278598 no 3089 0.0942531503407122 4347 738374
SGTC_2253 7938677 135.83 µM -1.31936553266263 0.0794327583878524 no 3090 0.0935234694513292 4440 2301972
SGTC_581 0958-0271 211 µM -1.32877187329465 0.0779621779294105 no 3091 0.0919616221698649 4395 4591145
SGTC_3288 9119690 36.221 µM -1.32900356458698 0.0779262179490657 no 3092 0.0919233969297727 4377 17595618 YKL019W RAM2
SGTC_618 k072-0232 33.2 µM -1.33045821157578 0.0777007348876991 no 3093 0.0916836730049586 4431 5872756 YGL099W LSG1
SGTC_2147 5545932 89.7195 µM -1.33046054168913 0.0777003740974062 no 3094 0.0916832893772455 4429 797404
SGTC_3196 9111891 49.47 µM -1.33666881195739 0.0767436058927662 no 3095 0.0906653832910502 4369 18891510
SGTC_283 0987-0079 11.7 µM -1.33824126257022 0.076502700336725 no 3096 0.0904089011232358 4395 411556
SGTC_3226 9131256 49.47 µM -1.33966786564443 0.076284637291271 no 3097 0.0901766745981764 4363 17178073
SGTC_2211 7117706 200 µM -1.34278654833304 0.0758095795295017 no 3098 0.0896705501638862 4331 822771
SGTC_389 tpck 16.7 µM -1.34536703503046 0.0754182094996694 no 3099 0.0892533676612981 4441 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2944 9067346 25.62 µM -1.34844966466883 0.0749527026005276 no 3100 0.0887568996623626 4341 6473075
SGTC_577 r071-0003 38.6 µM -1.34915161675292 0.0748470080391743 no 3101 0.0886441358985288 4365 4568517 YMR134W ERG29
SGTC_853 0419-0306 21 µM -1.35034044279387 0.0746682631450654 no 3102 0.0884534026358124 4422 762713
SGTC_2653 dihydrofissinolide 100 µM -1.35318734767496 0.0742415435539761 no 3103 0.0879978931195297 4450 6857746
SGTC_227 fluconazole 33.516 µM -1.35883880085026 0.0733999746903233 no 3104 0.0870988375506212 4406 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2151 5563267 85.4165 µM -1.36101444550641 0.0730779473465105 no 3105 0.0867545622198661 4472 5310824
SGTC_1812 st052057 4.327 µM -1.36171394403747 0.0729746413157189 no 3106 0.0866440894633816 4425 3645418
SGTC_2338 7999974 200 µM -1.36318160304102 0.0727582522039978 no 3107 0.0864126418694921 4402 315925
SGTC_1328 1441-0025 69.2 µM -1.36568231555389 0.0723906836801208 no 3108 0.0860193486729316 4397 4562601
SGTC_1436 4092-1007 8.32 µM -1.36753044380903 0.0721199511108433 no 3109 0.0857295507844602 4409 2881121
SGTC_253 dyclonine 31.25 µM -1.36762816895815 0.072105656974523 no 3110 0.0857142472498025 4510 3180 An oral anasthetic.
SGTC_61 0978-8327 98.565 µM -1.36973730607367 0.0717976850709005 no 3111 0.0853844593884005 4336 6150059 YHR072W ERG7
SGTC_3253 9135987 49.47 µM -1.37481092110582 0.0710609792985397 no 3112 0.0845950357092283 4422 4182430
SGTC_2644 guaiazulene 100 µM -1.37483478882269 0.071057527397874 no 3113 0.0845913350191391 4446 3515 A coloring agent.
SGTC_1188 1403-0014 4.57 µM -1.38031918247411 0.070267748879983 no 3114 0.0837441956410683 4439 9614867
SGTC_2291 7917025 104.35 µM -1.38338040753529 0.069829863245296 no 3115 0.0832741274105104 4311 2964612
SGTC_681 1642-0006 26.6 µM -1.38846420299581 0.0691073077201347 no 3116 0.0824978689442977 4439 4446530
SGTC_2455 5377712 9.75 µM -1.3910998899295 0.0687349745906745 no 3117 0.0820975691344471 4420 2243908
SGTC_2226 7298446 200 µM -1.39983903711947 0.0675114912795533 no 3118 0.0807807625135412 4441 3283010
SGTC_1277 0873-0036 22 µM -1.40338192646583 0.0670203068216552 no 3119 0.0802514897750748 4512 5965735
SGTC_1513 0337-0559 19 µM -1.41234154590343 0.0657904833410053 no 3120 0.0789247094885166 4433 775073
SGTC_344 k064-0035 6.43 µM -1.41633824592623 0.0652475582937288 no 3121 0.0783382475515861 4394 5088750
SGTC_2786 7743617 45.45 µM -1.41836419676793 0.0649736772739963 no 3122 0.0780422314595596 4379 583674
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.41861620370481 0.0649396718583884 no 3123 0.0780054696008416 4475 16486 A toxic proline analog.
SGTC_443 clozapine 122 µM -1.41886300538386 0.0649063822242335 no 3124 0.0779694798020312 4436 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3334 9142812 21.919 µM -1.41956828148751 0.0648113246783847 no 3125 0.0778667025207841 4453 45283678
SGTC_294 k038-0071 157 µM -1.41976436783202 0.064784915254155 no 3126 0.0778381458566911 4466 24152826
SGTC_1597 7-benzyloxygramine 47.5 µM -1.42270417719113 0.0643899750044166 no 3127 0.0774109645966353 4348 260807
SGTC_2512 diallyl trisulfide 49.23 µM -1.43063752579474 0.0633335266934007 no 3128 0.0762670633806241 4499 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1473 k844-0725 134 µM -1.43392642332381 0.0628995357220444 no 3129 0.075796630260089 4491 54682906
SGTC_3355 9151058 44.0485 µM -1.43457604244354 0.0628140889974798 no 3130 0.0757039728056673 4477 17015728
SGTC_2210 7115885 190.385 µM -1.43469926558883 0.0627978912268705 no 3131 0.0756864067959369 4538 2927039
SGTC_711 k292-0785 179 µM -1.43544533643505 0.0626998891807939 no 3132 0.0755801173706377 4401 4146315
SGTC_980 1473-0395 201 µM -1.4365167565224 0.0625593586019402 no 3133 0.0754276758629032 4353 768876
SGTC_2508 celastrol 40.54 µM -1.43751691609938 0.0624283964592976 no 3134 0.075285584868149 4383 122724 Celastrol is a natural product and antioxidant.
SGTC_2464 5717415 7.67 µM -1.43926330196264 0.062200235144236 no 3135 0.0750379681002685 4418 5285744
SGTC_2881 9058953 51.95 µM -1.441079263907 0.0619636742666867 no 3136 0.07478114550507 4403 17122249
SGTC_2833 9001315 45.46 µM -1.44660587729753 0.0612480543257435 no 3137 0.0740036695924607 4411 2989378
SGTC_833 3852-0053 558 µM -1.44709582630936 0.0611849256283475 no 3138 0.0739350434112485 4526 3123681
SGTC_3122 9126309 49.47 µM -1.44740349702953 0.0611453090282354 no 3139 0.0738919734499602 4560 17591206
SGTC_2206 7254556 146.969 µM -1.44927852438294 0.0609043081118922 no 3140 0.0736299079918344 4496 4398905
SGTC_136 0097-0015 404.482 µM -1.45172312499732 0.0605912149292568 no 3141 0.0732893033279984 4459 4861337
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.46313164463209 0.0591466841759959 no 3142 0.0717156802016136 4479 2346 DNA damaging agent; causes G2/M arrest.
SGTC_538 2922-0838 53.3 µM -1.46326823741894 0.0591295540744815 no 3143 0.0716969976769909 4495 777039
SGTC_1727 st034309 9.9045 µM -1.46390024756041 0.0590503443327448 no 3144 0.0716106028752451 4488 870305
SGTC_2942 9052777 62.25 µM -1.46501373392 0.0589109937772755 no 3145 0.0714585853786106 4486 6469503
SGTC_2212 7123476 200 µM -1.46848973773729 0.0584776385174287 no 3146 0.0709856208923706 4502 1085715
SGTC_663 1486-0733 13.9 µM -1.46971743381238 0.0583251805679222 no 3147 0.070819149504691 4490 722445 YPR165W RHO1
SGTC_148 3253-0744 288.01 µM -1.47104443765826 0.0581607416528083 no 3148 0.0706395498134944 4355 6893655
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.47111289593237 0.0581522683694518 no 3149 0.0706302940201059 4476 3256 An antibiotic and ribosome inhibitor.
SGTC_1786 berberine 21.6 µM -1.47163754634231 0.0580873630302419 no 3150 0.0705593904267398 4386 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3065 9113888 49.47 µM -1.47747676298857 0.0573688208150114 no 3151 0.0697739413198695 4498 16648368
SGTC_1440 4100-1550 40 µM -1.48488380367106 0.0564674341911463 no 3152 0.0687873035700418 4515 742806
SGTC_2208 7283366 200 µM -1.48604659176736 0.0563269499219169 no 3153 0.0686333987992768 4477 898663
SGTC_2229 7354935 190 µM -1.48979349601725 0.0558761347891956 no 3154 0.0681392708980487 4454 318112
SGTC_2149 5554786 194.827 µM -1.49351824411633 0.0554308115507931 no 3155 0.0676507911262973 4522 745063 YPR165W RHO1
SGTC_400 oxethazaine 37.5 µM -1.4953537364108 0.0552123969617178 no 3156 0.0674110738579608 4512 4621 A local anesthetic.
SGTC_469 w7 172 µM -1.49609477933092 0.0551244093430402 no 3157 0.067314479096282 4591 45115570 A P450 inhibitor.
SGTC_191 3914-0123 66.505 µM -1.49767290154017 0.05493740039669 no 3158 0.0671091278470671 4559 3144412
SGTC_3220 9131269 49.47 µM -1.5043576571714 0.054150804594063 no 3159 0.0662446503286353 4504 17722206
SGTC_557 1315-0110 16.2 µM -1.50763295033189 0.0537686675987255 no 3160 0.0658242473329248 4477 6833801
SGTC_2063 5246145 200 µM -1.50809897781843 0.0537144689364171 no 3161 0.0657645984028374 4537 711240
SGTC_2848 9016370 25.97 µM -1.50995254351133 0.053499328760472 no 3162 0.0655277669447035 4471 7894410
SGTC_2215 7188065 200 µM -1.51493326499525 0.0529246062778201 no 3163 0.0648946525880164 4559 940217
SGTC_472 calcifediol 10 µM -1.51830777061634 0.0525380146832954 no 3164 0.0644684148350698 4539 5283731 A vitamin D metabolite.
SGTC_1856 st057054 55.7 µM -1.52433029398662 0.0518536325777436 no 3165 0.0637131116266453 4481 1266018
SGTC_1721 st082152 9.2685 µM -1.52442997851288 0.0518423646092506 no 3166 0.0637006680503517 4446 5296051
SGTC_1279 0874-0590 65.2 µM -1.52629241292309 0.0516321995418261 no 3167 0.0634685286619141 4578 3523074
SGTC_2736 butenafine 14.65 µM -1.52630513687845 0.051630766049405 no 3168 0.0634669449776312 4457 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2155 5570423 76 µM -1.52816717634714 0.0514213278873144 no 3169 0.0632355180503512 4491 797402
SGTC_2682 pyrogallin 40.03 µM -1.53268124151223 0.0509163998756889 no 3170 0.0626772066509209 4518 822798 An ATP competetive kinase inhibitor.
SGTC_2233 sulbentine 40.3845 µM -1.5338814189771 0.0507828184510326 no 3171 0.0625294139767784 4509 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1522 st012842 45.6 µM -1.54278673768152 0.0498003415562755 no 3172 0.0614412641805744 4354 3491067 YOR116C RPO31
SGTC_1646 st011709 75.6 µM -1.54308141560711 0.0497680923088022 no 3173 0.0614055116278453 4481 5757843
SGTC_1292 0kpi-0043 232 µM -1.54526926680051 0.0495291768768384 no 3174 0.0611405730144383 4532 3333905
SGTC_1443 4112-3303 14 µM -1.54614520463169 0.0494337806138151 no 3175 0.0610347517801567 4559 704433
SGTC_1724 st037281 8.293 µM -1.55266183322813 0.0487286670976331 no 3176 0.0602519725145784 4472 574124 YDL195W SEC31
SGTC_2156 5649887 115 µM -1.55806683090153 0.0481499535601917 no 3177 0.0596087032553915 4556 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2001 4023502 57.655 µM -1.56109995057807 0.0478276140618744 no 3178 0.0592500848790462 4528 108941 YCR052W RSC6
SGTC_952 1185-0122 232 µM -1.56195556215269 0.0477369985335828 no 3179 0.0591492289000259 4482 678600
SGTC_2378 9074213 121.43 µM -1.57069841373001 0.0468189256194895 no 3180 0.0581263589191908 4511 657714
SGTC_933 2914-0560 114 µM -1.5733943974134 0.046538699279979 no 3181 0.0578137617439506 4543 463887
SGTC_1575 cyproterone acetate 48 µM -1.57850198584915 0.04601149730799 no 3182 0.0572251661385897 4521 9880 An androgen receptor antagonist and liver toxin.
SGTC_3321 9137793 26.8275 µM -1.58070270161849 0.0457858248255211 no 3183 0.0569730151869852 4503 4904192
SGTC_258 haloperidol 50.781 µM -1.58689741937831 0.0451553607387141 no 3184 0.056267939752385 4526 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2948 9070189 9.45 µM -1.58837183990275 0.0450063362510008 no 3185 0.0561011406559742 4482 6473636 YDL196W YDL196W
SGTC_1221 2958-7315 257 µM -1.58871961790319 0.0449712429559415 no 3186 0.0560618539160865 4565 4562705
SGTC_271 rotenone 740 µM -1.58895059200814 0.0449479481860877 no 3187 0.0560357739202015 4573 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2997 9067075 71.4286 µM -1.59272946046779 0.044568210055612 no 3188 0.0556104477739556 4499 27209819
SGTC_1216 1165-0504 9.65 µM -1.59503166532366 0.0443381313694197 no 3189 0.0553525774706111 4570 6304004
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.59658004203907 0.0441839281520589 no 3190 0.0551796753183334 4558 616764
SGTC_1038 k292-0204 154 µM -1.59928629971192 0.0439154496690661 no 3191 0.0548785011413342 4494 4454212
SGTC_3123 9126162 49.47 µM -1.60269494281749 0.0435791639736104 no 3192 0.0545010102974821 4547 25239884
SGTC_870 0573-2213 57.6 µM -1.61860448242269 0.0420369709458782 no 3193 0.0527661950267281 4546 3916321
SGTC_1685 st024049 53.0905 µM -1.62229277256165 0.041685828435512 no 3194 0.0523703377381813 4576 1941139
SGTC_272 doxorubicin 8.13 µM -1.62276525516159 0.041641018046058 no 3195 0.0523197978847291 4590 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3127 9126946 49.47 µM -1.623253352403 0.0415947677427967 no 3196 0.0522676284629216 4502 27243249
SGTC_1737 st035557 69.7 µM -1.6255246393768 0.0413800960376266 no 3197 0.0520254090663953 4410 5716916
SGTC_1761 st044296 37 µM -1.62623038373746 0.0413135754428365 no 3198 0.0519503274503232 4568 1826700
SGTC_2841 9004761 38.96 µM -1.63236410634757 0.0407390789584616 no 3199 0.0513014029184934 4504 2991039
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.64146513784024 0.0398986206064806 no 3200 0.0503504490433709 4598 165506
SGTC_2231 micatex 6.853 µM -1.64284823015745 0.0397721377522639 no 3201 0.0502071692385565 4587 20737 An antifungal of unknown mechanism.
SGTC_3249 9135183 49.47 µM -1.64813029591863 0.0392920929552491 no 3202 0.0496629683074141 4518 4902779
SGTC_417 st075190 100 µM -1.6502857480943 0.0390975605436069 no 3203 0.0494422529145149 4560 222757
SGTC_1474 0330-0125 5.35 µM -1.65119006332512 0.0390161787098243 no 3204 0.0493498857350306 4627 X1474
SGTC_1984 st072354 53.1 µM -1.65727857900207 0.0384718400725131 no 3205 0.0487315830284085 4471 5762938
SGTC_524 r073-0010 27.8 µM -1.65796978811806 0.0384104362673618 no 3206 0.0486617822654271 4512 2772106
SGTC_3250 9135583 49.47 µM -1.65838184086807 0.0383738694398269 no 3207 0.0486202097468253 4580 7699353
SGTC_144 4161-2749 112.381 µM -1.6596249338216 0.0382637254699978 no 3208 0.0484949645575405 4575 797501 YMR168C CEP3
SGTC_504 lovastatin 124 µM -1.67627643149149 0.0368130262105081 no 3209 0.0468420295880835 4567 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2832 7992762 51.95 µM -1.68056473729172 0.0364467969878255 no 3210 0.0464237449949739 4497 2985177
SGTC_787 4152-0075 138 µM -1.68535422377632 0.0360412961754152 no 3211 0.0459601249303643 4615 9566539
SGTC_2207 7258803 200 µM -1.68561380840743 0.0360194244825362 no 3212 0.0459351039154437 4610 3666799
SGTC_1120 ficusin 1.78878 µM -1.68636948787338 0.0359558154542085 no 3213 0.045862327285146 4577 6199 A DNA cross-linker.
SGTC_2821 7996764 71.43 µM -1.69059053112857 0.0356022011680967 no 3214 0.045457517187264 4553 2987135
SGTC_2754 granisetron 64.02 µM -1.69117794560836 0.0355532177526822 no 3215 0.0454014109263611 4574 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1299 1079-1439 3.74 µM -1.6959576932302 0.0351566938712994 no 3216 0.0449469462044885 4575 323161
SGTC_160 3453-0671 289.699 µM -1.69906816478403 0.0349006060191218 no 3217 0.0446531704395827 4577 5322268
SGTC_2514 salinomycin 42.74 µM -1.7026067222314 0.034611137441054 no 3218 0.0443208456169444 4606 23682228 A polyether potassium ionophore.
SGTC_2971 9092186 9.93 µM -1.70596282108365 0.0343384196742436 no 3219 0.0440075010018047 4554 25236400
SGTC_423 5-fluorouracil 457 µM -1.7134685515109 0.0337348896197512 no 3220 0.0433131870892822 4515 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_13 0199-0087 65 µM -1.71593222125172 0.0335387008137084 no 3221 0.0430872242558612 4688 4589825
SGTC_2798 7813637 45.45 µM -1.71749327654869 0.0334148764679808 no 3222 0.0429445409289742 4588 956368
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.71816093081564 0.0333620325585447 no 3223 0.0428836327785267 4617 66535 A nucleotide analog.
SGTC_3294 9122953 26.2835 µM -1.71915269847535 0.0332836625755302 no 3224 0.0427932855998947 4571 16459826
SGTC_1873 rapamycin 2 nM -1.72076548368559 0.0331565432691725 no 3225 0.0426466940790403 4555 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_138 0850-0259 40.9225 µM -1.72630138051102 0.0327232445280988 no 3226 0.0421466035713751 4536 6813004
SGTC_1867 st057372 64 µM -1.73208332082667 0.0322756834919484 no 3227 0.0416293642113262 4584 688837
SGTC_427 1354-0053 47.3 µM -1.74007351808211 0.0316655145729626 no 3228 0.0409230547929086 4608 6813657
SGTC_77 0828-0286 12.516 µM -1.74317743604817 0.0314310698970229 no 3229 0.040651312793568 4503 745345
SGTC_1659 st012954 42.1 µM -1.74355911254726 0.031402340499416 no 3230 0.0406179991044197 4600 24207262
SGTC_40 0327-0103 19.753 µM -1.74377257956028 0.0313862819671628 no 3231 0.0405993768284983 4456 409036
SGTC_1573 oleylamine 1.06 µM -1.75070524249568 0.0308684366384377 no 3232 0.0399983479693177 4597 5356789 An amine of the fatty acid oleic acid.
SGTC_665 3914-0008 307 µM -1.75075021921001 0.0308651002683348 no 3233 0.0399944724387674 4584 1069549
SGTC_3317 9138495 8.753 µM -1.75265165831938 0.0307243244366101 no 3234 0.039830909151521 4532 17020139
SGTC_949 1165-0505 146 µM -1.7535864230734 0.0306553129192572 no 3235 0.0397506995478276 4591 6244267
SGTC_1572 epiandrosterone 68.9 µM -1.75693202376334 0.0304093660469021 no 3236 0.039464698206291 4573 441302 A steroid.
SGTC_2034 5197015 53.07 µM -1.75822647212064 0.0303146462764746 no 3237 0.0393544913500963 4609 780676
SGTC_1341 1486-1360 280 µM -1.75848036794549 0.0302960964518807 no 3238 0.0393329045473915 4614 3976547
SGTC_2468 5987765 72.9 µM -1.75852047113612 0.0302931673423001 no 3239 0.039329495763826 4647 26772094
SGTC_1249 0481-0015 10.2 µM -1.76470718407926 0.029844096733902 no 3240 0.0388064952847975 4558 4227577
SGTC_2480 5767542 37.17 µM -1.77040191554103 0.0294356317550055 no 3241 0.0383301054425591 4540 2867358
SGTC_2801 7907800 81.82 µM -1.77381449419018 0.0291930900846935 no 3242 0.0380469199178774 4590 6620925
SGTC_1449 4112-4002 201 µM -1.77543580282482 0.0290784420968621 no 3243 0.0379129783834311 4641 2059539
SGTC_3102 9121669 49.47 µM -1.77557722691415 0.0290684593052008 no 3244 0.0379013131504451 4642 41905072
SGTC_2213 7173844 200 µM -1.77634808355309 0.029014096409464 no 3245 0.0378377812430537 4636 892728
SGTC_1744 st037937 38.9 µM -1.77854967008657 0.0288592996108431 no 3246 0.0376568108978743 4629 1016152
SGTC_225 nsc-122657 1.016 µM -1.80301020983214 0.0271851722171505 no 3247 0.0356933056227624 4634 275685
SGTC_3056 9094900 49.47 µM -1.81280331781387 0.0265380150671524 no 3248 0.0349310810336776 4619 25236784
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.81349807514973 0.0264925966167708 no 3249 0.0348775176113275 4666 91467 include heat shock
SGTC_2715 st079500 56.4 µM -1.81704181819881 0.0262619404948999 no 3250 0.034605355201207 4635 28246688
SGTC_2049 5262831 67.185 µM -1.81737490914519 0.0262403467614819 no 3251 0.0345798634753351 4598 763417
SGTC_1804 st050076 49.1 µM -1.82733328642487 0.025601585299299 no 3252 0.033824836677961 4656 3895976
SGTC_2565 isoliquiritigenin 100 µM -1.83349565664691 0.025212870818039 no 3253 0.0333644469452336 4601 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.83405244761652 0.0251779940720457 no 3254 0.0333231045806658 4522 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2734 clemastine 41.6 µM -1.83502691602098 0.0251170517937994 no 3255 0.0332508507218758 4706 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_786 4544-0069 423 µM -1.8479696652504 0.0243192839754819 no 3256 0.0323033656476003 4630 748821 YLR208W SEC13
SGTC_2133 5320837 200 µM -1.8482954288963 0.0242994822061433 no 3257 0.0322798083269563 4641 2841355
SGTC_561 1550-0330 72.9 µM -1.84946055679029 0.0242287698733471 no 3258 0.0321956691052952 4618 6812934
SGTC_1477 0139-0234 16 µM -1.87514109229165 0.0227135480033303 no 3259 0.0303866578356373 4667 620880
SGTC_874 0599-0792 117 µM -1.88050926215452 0.022407114386628 no 3260 0.0300193526306289 4638 765305
SGTC_2699 st077704 54.6 µM -1.88708911082659 0.0220362771738182 no 3261 0.0295741705346811 4639 645852
SGTC_1687 st020778 55.3625 µM -1.88718756783106 0.0220307677643882 no 3262 0.0295675509286125 4683 4259299
SGTC_142 0335-0849 62.6745 µM -1.88748202599926 0.0220142975552695 no 3263 0.029547760822772 4611 3889043 YPR107C YTH1
SGTC_782 0083-0095 30.5 µM -1.89182268668053 0.0217727107871287 no 3264 0.0292573047601839 4637 3591729 An indicator and reagent.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.892728634742 0.0217225722076192 no 3265 0.0291969831785493 4611 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2367 9070478 135.38 µM -1.89687101193973 0.0214945583449362 no 3266 0.0289224820868827 4599 572802
SGTC_1486 3970-0793 4.53 µM -1.89895024887885 0.0213808730608209 no 3267 0.0287855088159375 4700 2844330
SGTC_560 2332-1943 155 µM -1.90395841941751 0.02110912944695 no 3268 0.0284577998638619 4660 21177716
SGTC_3094 9117742 49.47 µM -1.90862268371156 0.0208586797959227 no 3269 0.0281553917685542 4626 17149698
SGTC_1441 4106-0040 13 µM -1.90872620353691 0.0208531499129992 no 3270 0.0281487105155482 4704 2904180
SGTC_1802 st050112 57.9 µM -1.90976462482475 0.0207977475480798 no 3271 0.0280817629702868 4681 4662563
SGTC_1375 2910-0797 186 µM -1.91053081177594 0.020756949507948 no 3272 0.0280324515560528 4663 742508
SGTC_2680 butyl paraben 22.24 µM -1.91309699490071 0.0206207982460279 no 3273 0.0278678182022388 4727 7184 An antifungal and steroid mimetic.
SGTC_1181 1222-0449 220 µM -1.91430219916467 0.0205571165187058 no 3274 0.027790776805352 4680 658318
SGTC_2607 solasodine 47.35 µM -1.91917252827434 0.020301467851148 no 3275 0.0274812515028762 4599 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3152 9099253 49.47 µM -1.92290569035555 0.0201073395219384 no 3276 0.0272459475027338 4513 25236131
SGTC_630 4356-0227 183 µM -1.95243670341699 0.0186264709078251 no 3277 0.0254431894939833 4638 779312
SGTC_2665 lovastatin 100 µM -1.9613013823176 0.018200475520001 no 3278 0.0249219380714898 4706 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1185 1319-0113 81.3 µM -1.98444937496349 0.0171270505662929 no 3279 0.0236028832010753 4706 4672763
SGTC_2121 5257820 149.641 µM -2.00699405921454 0.0161340788182878 no 3280 0.0223751477750257 4697 791256
SGTC_1125 tnp00248 1.32998 µM -2.02093296206563 0.0155451577281188 no 3281 0.0216433525908265 4679 24207736
SGTC_1689 st020265 53.493 µM -2.02553710092612 0.0153547294521842 no 3282 0.0214061214050694 4677 5758320 YPR016C TIF6
SGTC_2388 9080168 200 µM -2.03028853712131 0.0151603126543217 no 3283 0.0211636093545522 4703 15943073
SGTC_627 1391-0720 175 µM -2.03446076668123 0.0149913432016379 no 3284 0.0209525802177341 4692 997839
SGTC_1462 k081-0014 26.5 µM -2.03544175894722 0.0149518502665695 no 3285 0.0209032215767016 4138 3270634
SGTC_2917 7979103 53.79 µM -2.03622135226273 0.0149205290931049 no 3286 0.0208640665473286 4674 2980565
SGTC_1680 diphenhydramine 100 µM -2.05807983774034 0.0140650139731039 no 3287 0.0197912350573859 4644 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1904 st060225 78 µM -2.06507231704208 0.0138004159174185 no 3288 0.019458079143024 4682 66595
SGTC_977 1348-1378 135 µM -2.09852098452009 0.0125932797363371 no 3289 0.0179295740872463 4688 X977
SGTC_2920 7982904 15.77 µM -2.10712250121046 0.0122980444297998 no 3290 0.0175534811823415 4677 6456808
SGTC_67 0335-0847 266 µM -2.11444869123078 0.0120513306326583 no 3291 0.0172384813336217 4674 4552207 YOR254C SEC63
SGTC_3306 9127676 59.7925 µM -2.1273296041177 0.0116279543973873 no 3292 0.0166963533339763 4663 41905287
SGTC_62 0180-0423 3.232 µM -2.12743485317376 0.0116245488985175 no 3293 0.0166919844246363 4675 30102 YGL099W LSG1
SGTC_2419 paclitaxel 166.5 µM -2.14597642776931 0.0110379603383294 no 3294 0.0159374296990191 4668 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2301 7769476 200 µM -2.14791075548889 0.010978274467267 no 3295 0.0158604228974487 4699 977820
SGTC_2029 5175081 200 µM -2.15325306007393 0.0108148880151849 no 3296 0.0156493978329324 4692 1380876
SGTC_3211 9128781 49.47 µM -2.16242610321072 0.0105392787113406 no 3297 0.0152926736723364 4621 17194361
SGTC_2406 ethylparaben 405.7 µM -2.16893118719696 0.010347557175779 no 3298 0.0150439542911115 4673 8434 A possible steroid mimic.
SGTC_1438 4092-1045 4 µM -2.18597890944363 0.00985947523463428 no 3299 0.0144085741875901 4750 1351342
SGTC_2284 7945075 39.21 µM -2.20408772458472 0.00936315185751697 no 3300 0.0137590876377868 4684 1245402
SGTC_2634 4'-methoxyflavone 100 µM -2.20890273407854 0.00923491824357138 no 3301 0.013590703500398 4681 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_58 0957-0393 9 µM -2.21262049792386 0.00913696068304558 no 3302 0.0134619103162849 4252 6997992
SGTC_2945 9067681 61.76 µM -2.22374272115282 0.00884931780874863 no 3303 0.0130828795704865 4736 16456930
SGTC_1957 st077035 62.4 µM -2.22533229470239 0.00880886325692985 no 3304 0.0130294694969151 4728 705593
SGTC_226 1,3-diallylurea 8.28947 mM -2.2479302840548 0.00825103561573234 no 3305 0.0122903178685926 4725 74537 YKL182W FAS1
SGTC_1178 0988-0033 191 µM -2.2652749600937 0.00784417376717315 no 3306 0.0117479058219814 4750 5392207
SGTC_1586 deoxycorticosterone acetate 53.7 µM -2.26853542544702 0.00776969389011943 no 3307 0.0116482961832661 4738 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3043 9092303 49.47 µM -2.27386076118332 0.00764938331062143 no 3308 0.0114871797923835 4725 25236084
SGTC_1165 k072-0275 30.3 µM -2.29169579875992 0.00725831268275847 no 3309 0.0109616015111708 4727 6153523 YGL055W OLE1
SGTC_2478 5763493 32.33 µM -2.29376078298341 0.00721419230609767 no 3310 0.0109021216028284 4711 1365576 YLR208W SEC13
SGTC_2470 5664817 21.68 µM -2.29553717410684 0.00717642742189991 no 3311 0.0108511792739429 4770 2859561
SGTC_908 3448-7491 47.7 µM -2.30269403475512 0.00702603805601731 no 3312 0.0106480320333266 4729 1203031
SGTC_3266 9136860 49.47 µM -2.31738290202866 0.00672606317856465 no 3313 0.0102414414487451 4528 4871271 YPR165W RHO1
SGTC_3091 9116372 49.47 µM -2.3261782574585 0.00655191304363121 no 3314 0.0100045215372627 4756 17169793
SGTC_1485 3909-9022 254 µM -2.35038104240653 0.006093105704 no 3315 0.00937710062486453 4786 714516
SGTC_3126 9127922 49.47 µM -2.35461519735882 0.00601583333157886 no 3316 0.00927094775751522 4691 45595682
SGTC_1916 st067606 49.2 µM -2.35475918642071 0.00601322090510278 no 3317 0.00926735642638386 4669 19590279
SGTC_2417 cerulenin 830 nM -2.36970352237405 0.00574749084807845 no 3318 0.00890117707598901 4735 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2622 2-methoxyxanthone 59.94 µM -2.37804723873354 0.00560370768542821 no 3319 0.00870229804528342 4735 71034 A hepatoprotective.
SGTC_2427 5545055 42.75 µM -2.40165014164709 0.00521411970873832 no 3320 0.00816065487319893 4729 5372858
SGTC_2795 7780010 54.55 µM -2.40988550208794 0.00508397009594008 no 3321 0.00797876380147231 4721 953673
SGTC_2878 9043973 25.97 µM -2.42041572067569 0.00492177084291728 no 3322 0.00775138623559383 4727 6465167
SGTC_2438 5259590 200 µM -2.43200318504238 0.00474862948540663 no 3323 0.00750778763665335 4755 1201127
SGTC_1463 k081-0032 34.1 µM -2.45159167010217 0.00446825915263743 no 3324 0.00711129770860255 4331 977755
SGTC_755 1995-0008 37.3 µM -2.48282716538153 0.00405168448544429 no 3325 0.0065172156287142 4757 689533
SGTC_3224 9130643 49.47 µM -2.4973360281302 0.00387028833867863 no 3326 0.00625651600784767 4750 17644395
SGTC_1374 2889-5571 141 µM -2.4976627789436 0.00386628831178167 no 3327 0.00625075272243277 4748 2853281
SGTC_932 2857-0803 154 µM -2.49956848959833 0.00384303265736709 no 3328 0.00621723305073413 4739 674898
SGTC_1335 1486-0900 202 µM -2.51343851730885 0.00367751731242563 no 3329 0.00597803080408794 4765 X1335
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.54667511585993 0.00330662660670994 no 3330 0.00543773152241811 4756 5282309
SGTC_1250 0485-0349 40.2 µM -2.55657087886609 0.00320289101404159 no 3331 0.00528547664267047 4735 6842794 YDL195W SEC31
SGTC_2978 9011784 42.97 µM -2.58232136788282 0.00294653988371048 no 3332 0.00490690761042098 4753 2994934
SGTC_3213 9129884 49.47 µM -2.60906915039972 0.00269998225014741 no 3333 0.00453944469349254 4741 17190742
SGTC_1372 2752-0194 270 µM -2.63784020482059 0.00245570456120509 no 3334 0.00417179439010373 4748 823334
SGTC_223 busulfan 5 mM -2.65180846322374 0.0023444737027563 no 3335 0.0040030972389019 4787 2478 A DNA alkylator.
SGTC_2296 7971656 126.45 µM -2.65183485860995 0.00234426790266624 no 3336 0.00400278432536404 4754 666570
SGTC_1732 st034308 51.822 µM -2.73465829060139 0.00177344673312772 no 3337 0.00312225316677781 4736 830119
SGTC_480 am 92016 50 µM -2.75557805772991 0.00165087090893301 no 3338 0.0029294261444274 4787 2129 K+ channel blocker.
SGTC_3089 9117425 49.47 µM -2.79551648053833 0.00143805217155818 no 3339 0.00259084298911275 4771 9401657
SGTC_639 0833-0042 114 µM -2.81122933875527 0.00136142374727958 no 3340 0.00246762970884909 4790 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2411 st077133 39.94 µM -2.82240417565778 0.00130921667127273 no 3341 0.00238325319842184 4756 1403142 YNL221C POP1
SGTC_2977 9011197 71.43 µM -2.82861348143525 0.00128100514713316 no 3342 0.0023375061628627 4779 2704722
SGTC_433 pimozide 108 µM -2.87079271217132 0.00110361623326721 no 3343 0.00204721960579073 4750 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1264 0783-0040 158 µM -2.99117839863341 0.000713789300238304 yes 3344 0.00138951544245176 4767 2855798
SGTC_2663 amphotericin b 100 µM -3.01372297638907 0.000656732672014358 yes 3345 0.00129031663589332 4799 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2842 9000675 19.48 µM -3.11165057928056 0.000454471152415598 yes 3346 0.000930222825204086 4778 2989072
SGTC_2624 nerol 100 µM -3.13657434045723 0.000413149623595874 yes 3347 0.000854670478678852 4768 637566 A natural product oil.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -3.24055312092078 0.000275609739257596 yes 3348 0.000596490210998026 4802 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2623 humulene 100 µM -3.33445779312556 0.000189324421024619 yes 3349 0.000427329348905841 4783 6187145 An anti-inflammatory.
SGTC_832 4083-0019 164 µM -3.49951426220557 9.56320628625486e-05 yes 3350 0.000233053334518807 4802 1990758
SGTC_1675 st018485 24.5 µM -3.56083483796325 7.36502190611791e-05 yes 3351 0.000184838784101423 4794 3323024
SGTC_2330 7979373 200 µM -3.66083101601643 4.76904610089486e-05 yes 3352 0.000125699265695578 4791 1863007
SGTC_2996 9066192 71.4286 µM -3.83398806365565 2.19034452448846e-05 yes 3353 6.30411311617725e-05 4788 6472854
SGTC_2874 9043904 71.43 µM -3.99474405663099 1.03318258419381e-05 yes 3354 3.23820888256574e-05 4784 4463428
SGTC_2408 sulbentine 18.36 µM -4.11780443830933 5.70337006317635e-06 yes 3355 1.91249530004819e-05 4777 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3309 9129340 25.759 µM -4.16472627973896 4.52749062511976e-06 yes 3356 1.55863162236469e-05 4806 17158987