SGTCid condition conc unit TRS120|YDR407C.score TRS120|YDR407C.strain.pval TRS120|YDR407C.strain.significant TRS120|YDR407C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2289 7946404 165.07 µM 7.95955590350782 4.87609667614861e-16 yes 1 8.63289246845498e-16 5 1246120 YPR165W RHO1 SGTC_312 4092-0653 6.84 µM 7.43986120862322 3.08526433074595e-14 yes 2 5.03955695548845e-14 11 1148278 SGTC_2249 haloperidol 116.36 µM 7.41155746904254 3.83707366955689e-14 yes 3 6.24123421689065e-14 9 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1754 st042065 16.137 µM 7.34360406380149 6.45582450872574e-14 yes 4 1.03958799148476e-13 9 1126236 YIL048W NEO1 SGTC_1364 1653-0028 37.6 µM 6.84335304647458 2.57808883242929e-12 yes 5 3.8680339901302e-12 1 5718652 SGTC_178 4092-0806 87.505 µM 6.44409345084535 4.08412636641489e-11 yes 6 5.81467082695135e-11 8 2169044 SGTC_2285 7945142 200 µM 6.18084053188767 2.31346517007733e-10 yes 7 3.18805996821024e-10 4 2970608 SGTC_320 4092-0846 5.34 µM 5.93387418566217 1.105297274825e-09 yes 8 1.47934294703447e-09 8 1359356 SGTC_2257 7960413 200 µM 5.34129118184116 3.67718666372073e-08 yes 9 4.61434402583686e-08 12 2974689 YIL048W NEO1 SGTC_1818 st052136 56.3 µM 5.16195757308156 9.91389253424152e-08 yes 10 1.22190342821557e-07 9 674169 SGTC_1628 st004252 77.7 µM 4.90721811133725 3.83963552880247e-07 yes 11 4.61886424955351e-07 4 692968 SGTC_1072 oxiconazole 14.9 nM 4.2558498930118 9.1505774794764e-06 yes 12 1.04128199456404e-05 17 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2688 kanamycin b 96.69 µM 4.23777002214546 9.93324167517877e-06 yes 13 1.12875416976586e-05 17 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2250 alverine citrate 130 µM 4.17011839135164 1.34656000978225e-05 yes 14 1.52220720444634e-05 29 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2437 5741531 144.16 µM 4.01815436406236 2.6239179452962e-05 yes 15 2.93278842385609e-05 5 2262990 SGTC_262 fenpropimorph 62.5 µM 3.94665555978937 3.56351482353532e-05 yes 16 3.96252192873788e-05 14 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2418 pentamidine 31.67 µM 3.83255556976185 5.74818177322343e-05 yes 17 6.3409470155301e-05 14 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2318 6029776 164 µM 3.82631768478194 5.89826554036035e-05 yes 18 6.50372021608675e-05 4 818325 SGTC_1825 st052143 62.6 µM 3.81408145977611 6.20346596408959e-05 yes 19 6.83451895965712e-05 7 674173 SGTC_1297 1068-0111 14.1 µM 3.79113483048861 6.81635347987825e-05 yes 20 7.49802563137691e-05 5 767057 SGTC_1945 st075991 56.6 µM 3.71641802444258 9.23094692269214e-05 yes 21 0.000101033580420376 12 1084980 SGTC_184 1494-0393 24.714 µM 3.63556459952261 0.000127382016166847 yes 22 0.000138686236618931 38 3090647 SGTC_1568 digitonin 820 nM 3.52356324348639 0.000196929722921288 yes 23 0.000212892734484504 21 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1064 honokiol 6.76 µM 3.4435678052263 0.000266824981936996 yes 24 0.000287046309427748 15 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3136 9095672 49.47 µM 3.44128541134247 0.000269123065068401 yes 25 0.000289478746014033 10 17217380 SGTC_853 0419-0306 21 µM 3.42207221240626 0.000289212334439704 yes 26 0.000310729029675478 12 762713 SGTC_571 k831-0106 44.2 µM 3.38241557240599 0.000335167976261359 yes 27 0.000359256799421923 12 4783639 SGTC_924 2046-0044 21.3 µM 3.34128188070033 0.000389941572692231 yes 28 0.000416962557711697 13 3623589 SGTC_1814 st052110 31.539 µM 3.33948011593894 0.000392520956374895 yes 29 0.000419676798071563 18 674163 SGTC_1132 3456-3614 2.5 µM 3.32475778169857 0.000414198366660703 yes 30 0.000442476907080365 12 3125502 SGTC_183 3914-0051 30.55 µM 3.30201946763951 0.000449870386085113 yes 31 0.000479957038159744 7 1596232 SGTC_691 1548-0686 185 µM 3.25870907818806 0.000525812902373053 yes 32 0.000559601866387901 21 46495133 SGTC_2948 9070189 9.45 µM 3.14177699881052 0.000794022199616415 yes 33 0.000839629407977115 13 6473636 YDL196W YDL196W SGTC_800 3448-7362 155 µM 3.14104176489897 0.000796049703739074 yes 34 0.000841740116976959 69 15991913 SGTC_2453 5731132 22.18 µM 3.12903967354944 0.000829828154613863 yes 35 0.000876893135578956 15 1362040 SGTC_1693 xanthone 101.9 µM 3.12615149917071 0.000838151062868952 yes 36 0.000885551426256806 19 7020 An insecticide. SGTC_3298 9116858 71.43 µM 3.08397217928468 0.000968778898404132 yes 37 0.00102128347605924 12 2506942 SGTC_15 0266-0086 27.098 µM 3.08177808727338 0.000976060124719913 yes 38 0.00102884087599013 22 1712902 YIL048W NEO1 SGTC_2103 5378138 10 µM 3.07329284913119 0.00100469426412219 no 39 0.00105855307921745 11 244142 SGTC_2757 clomiphene 4.22 µM 3.06923370443603 0.00101866300488268 no 40 0.00107304318073803 30 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_847 0342-0274 5.54 µM 3.06271551647276 0.00104146731250853 no 41 0.00109669234739955 12 18097 SGTC_1773 st048542 73.5835 µM 3.05165331972664 0.00108124341033295 no 42 0.00113792393351989 43 3237138 SGTC_1906 st060206 94.7 µM 3.03939259301856 0.00112695292058506 no 43 0.00118527857035546 10 5133468 SGTC_2964 9083345 53.42 µM 3.03786556108042 0.00113276821459473 no 44 0.0011913011167162 29 17741579 SGTC_568 1193-0097 7.48 µM 3.011152758082 0.00123904630874483 no 45 0.00130128942901105 47 3646150 SGTC_2413 inermin 26.06 µM 3.0059826905806 0.00126064059502088 no 46 0.00132362033375059 32 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1329 1447-1697 50.6 µM 2.98899252906664 0.00133405206122832 no 47 0.00139949487776124 8 2840515 SGTC_637 1181-0519 7.26 µM 2.9765629838389 0.00139021014749844 no 48 0.00145749599803518 21 6252091 YGR060W ERG25 SGTC_1073 triclabendazole 3.09 µM 2.95989567239841 0.00146890454422734 no 49 0.00153871618937438 12 50248 An antihelmetic and likely tubulin inhibitor. SGTC_290 2043-6722 48.1 µM 2.92216773639518 0.00166226392249829 no 50 0.00173802141430873 10 773758 YLR208W SEC13 SGTC_2696 st077691 74.316 µM 2.90381779099859 0.00176445062729 no 51 0.00184321317133187 27 757133 SGTC_3278 9139605 49.47 µM 2.90121002155387 0.00177942770366755 no 52 0.00185862323218937 25 7958859 SGTC_1333 1482-0047 286 µM 2.877979477312 0.0019180390189342 no 53 0.00200115587806939 17 3811116 SGTC_16 erodoxin 22.806 µM 2.86628665129785 0.00199145626070718 no 54 0.00207658997334556 48 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_793 0488-0545 106 µM 2.86616910587605 0.00199220708962637 no 55 0.0020773612217075 13 292548 SGTC_892 0929-0076 29 µM 2.85921678161126 0.00203707534363553 no 56 0.00212344227256855 19 5751038 SGTC_708 3448-5400 146 µM 2.84455832664457 0.00213469577410334 no 57 0.00222365213356508 45 3462195 SGTC_1887 st057648 70.8 µM 2.8237730673117 0.00228039724370595 no 58 0.00237309882990888 18 688672 SGTC_1767 st044992 70.3 µM 2.77803896532779 0.00263317337987762 no 59 0.00273440298404494 12 9600693 SGTC_1797 st048695 56.8 µM 2.76877861575839 0.00271034116008544 no 60 0.00281334268599759 33 592262 YIL048W NEO1 SGTC_2764 methyldopa 94.69 µM 2.75257160069276 0.00285032409687642 no 61 0.00295646074274137 20 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_68 0986-0284 82.829 µM 2.74561011073966 0.00291242871696033 no 62 0.00301992477001189 27 423278 YIL048W NEO1 SGTC_3139 9095020 49.47 µM 2.68200967189022 0.00353884071679831 no 63 0.0036590671979193 14 25236292 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.67755017301111 0.00358699999151541 no 64 0.00370813720783152 17 3256 An antibiotic and ribosome inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.65116787154804 0.0038841355318406 no 65 0.0040106980811371 15 688669 SGTC_1182 1222-0449 220 µM 2.6472412724072 0.00393019671783681 no 66 0.00405757155249114 12 658318 SGTC_207 4185-0010 4.486 µM 2.64444658006694 0.00396327744459736 no 67 0.00409123106423129 45 3761753 SGTC_2507 purpurin 79.67 µM 2.64261563315044 0.00398508532470473 no 68 0.00411341841852482 24 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_193 1273-0060 1.558 µM 2.627773531321 0.00416586905790207 no 69 0.00429728564871979 17 2847393 YHR072W ERG7 SGTC_335 4077-0256 27.6 µM 2.60065186801896 0.00451526540595392 no 70 0.00465234122025006 26 3121989 SGTC_3177 9107506 49.47 µM 2.58672695221962 0.0047046295489514 no 71 0.00484461693914669 13 8897194 SGTC_843 0310-0051 143 µM 2.58477885217696 0.00473167895549938 no 72 0.00487207372018489 20 2065037 SGTC_1027 k015-0025 8.67 µM 2.58452043725794 0.00473527745231237 no 73 0.00487572625390273 22 3598955 SGTC_3087 9117406 49.47 µM 2.57630392461202 0.00485097465637083 no 74 0.00499314129503423 24 42546093 SGTC_2572 astragaloside iv 100 µM 2.57301876323703 0.00489793389525859 no 75 0.00504078709746611 35 45006101 An anti-inflammatory agent. SGTC_1715 st032160 10.2275 µM 2.57182406134561 0.00491511156685913 no 76 0.00505821439515642 26 5289825 SGTC_1768 st044301 37.178 µM 2.57004215410869 0.00494083194750613 no 77 0.00508430703399801 35 3931349 SGTC_3213 9129884 49.47 µM 2.54213612171306 0.00535957354369279 no 78 0.00550886278239766 25 17190742 SGTC_112 phenothiazine 287.218 µM 2.53004063831887 0.00555067073201743 no 79 0.0057024658133663 20 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_807 1315-0151 48 µM 2.50873669439087 0.00590201191913584 no 80 0.0060581881429667 44 4011080 SGTC_2164 5685496 200 µM 2.5039096860068 0.00598430737393547 no 81 0.00614146917362905 21 759046 SGTC_2671 danthron 100 µM 2.49790452228849 0.00608810817260583 no 82 0.00624649183906568 45 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_11 0438-0307 1.3 µM 2.49787669441888 0.00608859287527101 no 83 0.00624698219230241 28 4011476 SGTC_2319 6033012 152.6 µM 2.49465697067853 0.00614490504222409 no 84 0.00630394739011819 22 847246 SGTC_761 k216-0224 480 µM 2.49232550499619 0.00618596933565589 no 85 0.00634548360809308 31 1340404 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.48697516191606 0.00628112556195841 no 86 0.00644171967859899 31 4330530 SGTC_3160 9100216 49.47 µM 2.46273140585066 0.00672873321482308 no 87 0.00689415823244059 11 17191039 SGTC_1428 4049-0204 61.7 µM 2.45388889025554 0.00689887395990159 no 88 0.00706603198147089 25 X1428 SGTC_2396 5342950 42.78 µM 2.44547502297031 0.00706428280542367 no 89 0.00723307341134161 76 1886677 SGTC_2692 st077426 47.7 µM 2.44009651945195 0.00717184384967174 no 90 0.00734166910462072 39 25238571 SGTC_2855 9016525 58.44 µM 2.40812841742164 0.0078414591130641 no 91 0.0080172698792672 31 43811474 SGTC_2970 9090938 41.86 µM 2.39266323223086 0.00818470207355568 no 92 0.00836329297461213 37 17217104 SGTC_1217 1183-1422 255 µM 2.37993147110785 0.00847711435872039 no 93 0.00865792896800375 24 2849664 SGTC_1421 4029-0249 71.4 µM 2.37916208756511 0.00849507506904111 no 94 0.00867602205162032 27 2894095 SGTC_1871 st057448 67.3 µM 2.35598207289885 0.00905208535615006 no 95 0.00923690460957895 40 691747 SGTC_364 0083-0097 67.7 µM 2.3522342487284 0.00914508641458652 no 96 0.00933050946327654 38 5207356 SGTC_2662 daunorubicin 22.37 µM 2.34670028070814 0.00928393938196108 no 97 0.00947024189640456 46 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_395 anisomycin 6.25 µM 2.34236099117359 0.00939410358647311 no 98 0.0095810853585866 34 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_777 1315-0167 517 µM 2.33901742970376 0.0094797669248086 no 99 0.00966726572546855 27 4221767 SGTC_2769 toremifene 3.73 µM 2.3355805533544 0.00956853217738918 no 100 0.00975655654477795 41 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1856 st057054 55.7 µM 2.3315117127124 0.00967455789682562 no 101 0.00986319659417845 26 1266018 SGTC_1692 fluoroquinolonic acid 71 µM 2.32972316109505 0.00972148780643557 no 102 0.0099103937983826 25 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_363 0455-0021 3.06 µM 2.32342903911852 0.00988822481588206 no 103 0.0100780578079068 55 4597466 SGTC_2508 celastrol 40.54 µM 2.30923429318858 0.0102734493124379 no 104 0.0104652917809786 22 122724 Celastrol is a natural product and antioxidant. SGTC_1465 k213-0056 144 µM 2.30458077643193 0.0104025561245078 no 105 0.0105950318115964 50 24048857 YMR208W ERG12 SGTC_910 3454-3003 490 µM 2.28825085725648 0.0108668664603842 no 106 0.0110614582799508 44 820824 SGTC_2038 4100038 30.985 µM 2.28156102350802 0.0110622261178954 no 107 0.0112576350344142 51 3596803 SGTC_616 4092-0450 108 µM 2.27937096035577 0.0111268416676138 no 108 0.0113225115300363 26 787165 SGTC_545 4218-0007 221 µM 2.27899103283294 0.0111380843804227 no 109 0.0113337991775738 42 2840508 SGTC_926 2268-1401 59.4 µM 2.27838349470186 0.0111560830126533 no 110 0.0113518694584578 40 2931578 SGTC_2331 7980721 200 µM 2.2556605847328 0.0118476705661191 no 111 0.0120459479098687 48 2981221 SGTC_2550 chrysin dimethyl ether 71.87 µM 2.24483666167374 0.0121899825070178 no 112 0.0123893101321937 13 88881 An O-methylated flavonoid and antioxidant. SGTC_2447 5741742 33.78 µM 2.24099096520788 0.0123136516969295 no 113 0.0125133301224457 51 1776504 SGTC_156 3474-0145 5.642 µM 2.24055533652069 0.0123277288656029 no 114 0.0125274462732277 30 2265471 SGTC_1796 st049173 110.4 µM 2.23962880986278 0.0123577155741012 no 115 0.0125575153766542 31 94134 SGTC_1354 1498-1681 81 µM 2.2387287508411 0.0123869061485478 no 116 0.0125867853192035 44 5754243 SGTC_1525 8-methoxypsoralen 92.5 µM 2.23145462425969 0.0126250190523884 no 117 0.0128255150019662 64 4114 Related to psoralen; DNA damaging agent. SGTC_2444 5485484 36.41 µM 2.22862065177666 0.0127188537117599 no 118 0.0129195778893667 50 6790631 SGTC_3207 9114163 49.47 µM 2.22702906880446 0.0127718162102996 no 119 0.0129726655467899 51 849233 SGTC_2545 solidagenone 89.61 µM 2.22263865923989 0.0129189043930292 no 120 0.0131200875987067 11 6708572 An anti ulcer agent SGTC_3284 9108171 64.8615 µM 2.21826366064202 0.0130669311479327 no 121 0.0132684301897164 36 8687505 SGTC_42 0133-0086 60.653 µM 2.2108264721455 0.013321931514778 no 122 0.0135239279657478 59 162923 Model of phenazepam hydroxylation. SGTC_197 4544-0043 41.561 µM 2.19909823537531 0.013732792441074 no 123 0.0139354689949856 71 896523 SGTC_78 0336-0123 156.75 µM 2.18944259470948 0.0140792063649226 no 124 0.0142823433091268 35 6765896 SGTC_2815 7968870 71.43 µM 2.18557877471289 0.0142199232862727 no 125 0.0144232184444588 42 2977326 YHR190W ERG9 SGTC_1834 st055981 52.8 µM 2.18343842723598 0.0142983930677073 no 126 0.0145017693380062 46 471719 YDL150W RPC53 SGTC_1185 1319-0113 81.3 µM 2.17166082436353 0.014736890342813 no 127 0.0149406277561848 36 4672763 SGTC_2200 6600604 21.907 µM 2.16908213938828 0.0148344273657358 no 128 0.0150382242099753 41 2904777 SGTC_2591 skatole 100 µM 2.16895889440305 0.0148391028919419 no 129 0.0150429023967432 44 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.15268482211365 0.0154677252800443 no 130 0.015671728571941 52 6708739 YPR165W RHO1 SGTC_938 3126-1755 342 µM 2.14884136929026 0.0156194807836654 no 131 0.0158234883959397 21 1777771 SGTC_3126 9127922 49.47 µM 2.14288114056489 0.0158573416933095 no 132 0.016061321854737 88 45595682 SGTC_1798 st045719 60.953 µM 2.14233895200443 0.015879132687608 no 133 0.0160831082661123 38 3980186 SGTC_1496 4469-0713 57.4 µM 2.14089136471039 0.0159374382173744 no 134 0.0161413998399068 37 746691 SGTC_63 0099-0242 26.702 µM 2.13995384845691 0.0159752970910151 no 135 0.0161792483352257 66 3898502 YLR359W ADE13 SGTC_24 0417-1663 219 µM 2.13981370817929 0.0159809628675111 no 136 0.0161849124696054 30 4329390 SGTC_1955 wogonin 32.4 µM 2.13298471169775 0.0162591494654889 no 137 0.0164629901815819 35 5281703 A flavanone. SGTC_1518 st038567 90.8 µM 2.13040863348355 0.0163651610415529 no 138 0.0165689458245772 34 77966 SGTC_1480 1070-0044 41.2 µM 2.12799941675252 0.0164648409624165 no 139 0.0166685659689482 38 3124987 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.1152218212587 0.0170022381078416 no 140 0.0172055229811125 43 688801 SGTC_862 0452-0056 10.2 µM 2.11331746344605 0.0170836013048739 no 141 0.0172868024992495 21 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_877 0771-0151 33.1 µM 2.10297524457392 0.0175313042380253 no 142 0.0177339667632409 35 6166523 SGTC_1047 2043-3044 82 µM 2.10122166538559 0.0176081993397136 no 143 0.0178107562067453 56 669592 SGTC_1685 st024049 53.0905 µM 2.09671343736236 0.0178072093156014 no 144 0.018009475137042 39 1941139 SGTC_2617 dihydrotanshinone i 20.83 µM 2.09527684673197 0.0178710275628681 no 145 0.0180731947179788 73 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2790 5423970 71.43 µM 2.07352881496998 0.0188612328583695 no 146 0.0190615461531937 64 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1423 4048-0112 5.59 µM 2.06216734597014 0.0193968370723788 no 147 0.0195959031995875 44 X1423 SGTC_1052 3253-3998 198 µM 2.0389765105475 0.0205302945024905 no 148 0.0207261859692013 40 5450317 SGTC_1087 pterostilbene 9.05 µM 2.0348760632547 0.0207364336889829 no 149 0.0209316725366005 54 5281727 Similar to reservatol, lowers cholesterol. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.03415003235202 0.0207731150217159 no 150 0.0209682353773464 65 6728940 SGTC_430 0958-0115 16.4 µM 2.03411244637035 0.0207750154768901 no 151 0.0209701296741137 58 6833180 SGTC_2946 9065502 71.43 µM 2.02876624093964 0.0210468388282938 no 152 0.0212410526638954 25 16489101 SGTC_2000 st075254 36.4 µM 2.02541476677251 0.0212187717086028 no 153 0.0214123962034507 41 17234175 SGTC_2393 9031399 185.94 µM 2.01540641921485 0.0217392929725002 no 154 0.0219310411961982 64 1526623 YDL150W RPC53 SGTC_278 4092-0821 23.9 µM 2.01220803969459 0.0219078943974471 no 155 0.022099005679985 28 877900 SGTC_1256 0570-0116 285 µM 2.00905369908575 0.0220752544678584 no 156 0.0222657195910678 60 410638 SGTC_2616 abietic acid 100 µM 2.00001907759221 0.0225605878340248 no 157 0.0227491019501873 49 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3347 9188721 44.724 µM 1.9944456177838 0.0228644535607867 no 158 0.0230516887266525 49 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2102 5377816 72.7585 µM 1.97976471522108 0.0236814028906404 no 159 0.0238649864591225 57 1379702 SGTC_2871 9038510 12.99 µM 1.97656652487719 0.0238625920289292 no 160 0.0240453245748271 72 4945164 SGTC_2354 9060492 162 µM 1.97361524874774 0.0240308249866021 no 161 0.0242127542571475 40 6471895 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.97296458256954 0.0240680489838763 no 162 0.0242497988240917 32 6708561 SGTC_2462 5162487 171.77 µM 1.96460861164941 0.024550407378421 no 163 0.0247297772439217 54 2259986 SGTC_1505 k297-0037 20.6 µM 1.96206861160683 0.0246986300690313 no 164 0.0248772483637755 49 4089396 SGTC_57 miconazole 162.5 nM 1.95773347001505 0.0249533429724912 no 165 0.0251306478392393 79 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3081 9117243 49.47 µM 1.95280203447019 0.0252457654442423 no 166 0.0254215286930151 97 45595589 SGTC_2025 5147754 141 µM 1.95226077397187 0.0252780350811062 no 167 0.0254536260193347 39 315777 YLR208W SEC13 SGTC_3133 9127736 49.47 µM 1.95178808371211 0.0253062448628083 no 168 0.0254816848146025 39 27243420 SGTC_1868 st057644 42.7 µM 1.94544566010867 0.0256873137054482 no 169 0.0258606819112449 65 688665 SGTC_1305 1181-0477 144 µM 1.94372699224255 0.0257913989127451 no 170 0.0259641909140381 60 6252086 SGTC_3170 9103054 49.47 µM 1.94338079610926 0.0258124077437777 no 171 0.0259850829093164 57 16432970 SGTC_2781 5567276 71.43 µM 1.94192314886479 0.0259010218789613 no 172 0.026073202273605 63 2853274 SGTC_1829 berberine 14.4 µM 1.93208273899472 0.0265059281402085 no 173 0.0266746472238678 68 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_769 0302-0231 76 µM 1.9149058715008 0.0275900950993239 no 174 0.0277522544488123 89 571869 YER009W NTF2 SGTC_195 4234-0266 16.654 µM 1.91215005407906 0.0277674310096896 no 175 0.0279284751263405 78 2303354 SGTC_2859 9028643 45.46 µM 1.91205198412482 0.0277737592378326 no 176 0.027934763342035 37 17151580 SGTC_1415 3966-0071 78.1 µM 1.91020443770573 0.0278932018923948 no 177 0.0280534480071044 57 2893185 SGTC_3287 9117173 37.0625 µM 1.89963608176354 0.0285846911766802 no 178 0.0287404468644054 20 2789709 SGTC_1872 amphotericin b 148 nM 1.89222468084036 0.02907807846291 no 179 0.0292305256467299 62 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_615 k087-0205 167 µM 1.88919718775119 0.0292816484665948 no 180 0.0294327057143788 55 9642773 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.87674608293353 0.0301313493916643 no 181 0.0302764516782108 56 229346 A bile salt which induces apoptosis. SGTC_411 enrofloxacin 100 µM 1.87655057268155 0.0301448529001255 no 182 0.0302898585824437 44 71188 A bacterial gyrase inhibitor. SGTC_310 1273-0058 1.06 µM 1.8755029575635 0.0302172951040584 no 183 0.0303617814969726 45 2734232 SGTC_489 paxilline 115 µM 1.85912287984993 0.0313688606778932 no 184 0.0315048614386072 55 105008 A toxic potassium channel blocker. SGTC_400 oxethazaine 37.5 µM 1.85617923227559 0.031579605885954 no 185 0.0317140076098608 63 4621 A local anesthetic. SGTC_3152 9099253 49.47 µM 1.85556502374469 0.0316237262854441 no 186 0.0317577914728599 108 25236131 SGTC_859 0439-0102 54.6 µM 1.85538691026657 0.0316365302228125 no 187 0.0317704976314293 78 610143 SGTC_1684 st024538 14.6195 µM 1.85378724274868 0.0317517166965393 no 188 0.0318848021611413 53 6732859 SGTC_3255 9139072 49.47 µM 1.85187226920652 0.0318900627065047 no 189 0.0320220834290522 50 17646060 SGTC_49 0717-0965 32.132 µM 1.84865476246779 0.0321236302051995 no 190 0.0322538398723845 67 5889349 YGL099W LSG1 SGTC_919 tnp00227 403.569 nM 1.84818819696656 0.0321576164068148 no 191 0.0322875611467747 79 1269246 A methoxyflavone. YNL221C POP1 SGTC_2398 5228213 48.84 µM 1.84593713580514 0.0323220086134711 no 192 0.0324506668930346 88 80771 YMR134W ERG29 SGTC_1292 0kpi-0043 232 µM 1.83248995437786 0.0333185433071263 no 193 0.033439228525786 56 3333905 SGTC_501 nsc-95397 161 µM 1.83186478321664 0.0333654818566485 no 194 0.0334857842525465 68 262093 SGTC_687 k029-0044 34.9 µM 1.82256735365359 0.0340699923311927 no 195 0.0341844719514624 38 5829338 SGTC_940 3232-1287 54.8 µM 1.82173942495364 0.0341333171761665 no 196 0.0342472664260609 53 1585493 YIL048W NEO1 SGTC_2178 5812956 200 µM 1.81964664067637 0.0342938171394121 no 197 0.0344064170346685 58 5403383 SGTC_2021 4019055 173 µM 1.8129957235479 0.0348080123385845 no 198 0.0349162404513893 113 44827708 YER133W GLC7 SGTC_3240 9133527 49.47 µM 1.81186494752323 0.034896061243198 no 199 0.0350035333531928 53 17617455 SGTC_2658 polymyxin b sulfate 77.05 µM 1.80915300304459 0.0351079744902032 no 200 0.0352136183018709 70 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.80658823871163 0.0353093573928846 no 201 0.0354132523383938 54 23665772 A membrane-active detergent. SGTC_867 0518-0118 155 µM 1.80617498342138 0.035341894271357 no 202 0.0354455056188843 75 6848158 SGTC_1096 rimcazole 32.2 µM 1.80568163296955 0.0353807694881144 no 203 0.0354840416138893 41 18528119 A dopamine reuptake inhibitor. SGTC_1218 1348-1416 30.7 µM 1.80492203781913 0.0354406929130614 no 204 0.035543441348421 66 6787668 SGTC_1367 1812-0510 76.9 µM 1.80478773095368 0.0354512968516866 no 205 0.0355539525143516 57 1142582 YDR527W RBA50 SGTC_1037 k284-1091 78.7 µM 1.80341195438293 0.0355600685128292 no 206 0.0356617707873953 56 3334711 SGTC_2778 tioconazole 65.09 nM 1.80210267216635 0.035663836925403 no 207 0.0357646266897015 101 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3001 9076041 71.4286 µM 1.80091657117453 0.0357580566294687 no 208 0.0358580153445259 57 16004211 SGTC_2266 7929956 200 µM 1.79847470440404 0.0359526722379649 no 209 0.0360509068579682 61 2967153 SGTC_1820 st053765 18.6 µM 1.79738343774457 0.0360399257492667 no 210 0.036137384117061 54 3690829 SGTC_3238 9133470 49.47 µM 1.79570697104758 0.0361743074215861 no 211 0.0362705663140647 55 3534688 SGTC_1623 st003709 20.3 µM 1.79378881734909 0.0363285651200854 no 212 0.0364234412526753 62 16192618 SGTC_3297 9117502 71.43 µM 1.79318398615472 0.036377317082778 no 213 0.0364717549044169 32 7453720 SGTC_735 3076-0345 636 µM 1.78812441401864 0.0367872409474184 no 214 0.0368779687721555 60 2888990 SGTC_491 tetrandrine 80.3 µM 1.77346801340497 0.0379960565546244 no 215 0.0380755938147448 65 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1611 st001856 99.4 µM 1.77247401768255 0.0380791981734255 no 216 0.0381579522882285 78 647478 SGTC_742 0kpi-0133 140 µM 1.76986343399402 0.0382982642691077 no 217 0.0383749467554865 64 2728852 SGTC_1230 0170-0365 3.77 µM 1.76899684606351 0.0383712104115297 no 218 0.038447200460422 89 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2382 9035899 200 µM 1.7647701402118 0.038728623883621 no 219 0.038801202479701 75 6462679 SGTC_1341 1486-1360 280 µM 1.76015981652974 0.039121564038042 no 220 0.039190356528958 70 3976547 SGTC_672 1441-0018 53.7 µM 1.75878479300892 0.0392393842670646 no 221 0.0393070343362437 57 251141 SGTC_2261 9010538 184.68 µM 1.75729981179863 0.0393669504985497 no 222 0.0394333599346902 63 6457250 SGTC_903 1134-0042 114 µM 1.75335674366392 0.0397073150332677 no 223 0.0397703955295065 66 701009 SGTC_1184 1269-1718 139 µM 1.74831827239446 0.040145712522928 no 224 0.0402044654625918 75 5403821 SGTC_2482 5981709 142.65 µM 1.74689117977366 0.0402705959901766 no 225 0.0403281080474185 85 877755 SGTC_1 0258-0098 57.368 µM 1.74636226121032 0.0403169611987656 no 226 0.0403740116460614 82 6790032 YDR047W HEM12 SGTC_2940 9060638 45.86 µM 1.7436789518685 0.0405528494422172 no 227 0.0406075437978091 64 4027022 SGTC_1156 4092-0367 4.88 µM 1.74021697688874 0.0408588436249728 no 228 0.0409104628562726 87 1357585 SGTC_2468 5987765 72.9 µM 1.73790337902905 0.0410643782369179 no 229 0.041113920099103 61 26772094 SGTC_2196 6573537 42.6665 µM 1.73312969749988 0.0414911107273099 no 230 0.0415363095023858 67 2903087 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.73164481866763 0.0416245784236696 no 231 0.0416684105706294 66 6708784 An antioxidant flavonoid SGTC_1327 1436-0082 2.18 µM 1.73146005159686 0.0416412104365087 no 232 0.0416848720078385 77 15992205 SGTC_2795 7780010 54.55 µM 1.72741820939756 0.0420063902008969 no 233 0.0420462913243737 79 953673 SGTC_560 2332-1943 155 µM 1.724558840454 0.042266296073908 no 234 0.0423035032034036 72 21177716 SGTC_2322 7413319 38.22 µM 1.72411476047395 0.0423067777523482 no 235 0.0423435639698997 98 1840400 SGTC_819 1013-0258 27.7 µM 1.72041473206883 0.0426452876704269 no 236 0.0426785404885873 69 5753198 SGTC_3144 9087057 49.47 µM 1.71197085024782 0.0434260089341584 no 237 0.0434510202510347 69 17249618 SGTC_900 1112-0045 141 µM 1.7102774453063 0.0435839617768245 no 238 0.0436072902559546 62 56211 YIL048W NEO1 SGTC_353 1988-1175 58.3 µM 1.70769186867174 0.0438260263137499 no 239 0.0438467658611408 89 2788357 SGTC_2254 7938975 95.19 µM 1.70510930651427 0.0440688900930042 no 240 0.0440870201224916 79 2969277 SGTC_2693 st077581 40.7 µM 1.69676757984385 0.0448607663352755 no 241 0.044870305166634 69 25238761 SGTC_3019 9081971 49.47 µM 1.69335142092742 0.0451883495610411 no 242 0.0451942979032755 73 16451803 SGTC_2048 5246248 200 µM 1.67280929434223 0.047198964607836 no 243 0.0471824222958531 67 677046 SGTC_566 0958-0068 16.5 µM 1.67052412203796 0.0474269965110975 no 244 0.0474078554706752 86 6815365 SGTC_541 4513-1321 94 µM 1.66846075126192 0.0476336529332839 no 245 0.0476121485261364 92 747515 SGTC_2851 9015922 71.43 µM 1.66833223215334 0.0476465485573332 no 246 0.0476248964145017 92 2996893 SGTC_1376 2910-0861 41.3 µM 1.66649302021444 0.0478314018211517 no 247 0.0478076286248172 74 1112859 SGTC_596 1155-0152 116 µM 1.66154544600131 0.0483315173618538 no 248 0.048301974757083 88 280313 SGTC_2801 7907800 81.82 µM 1.65937779687814 0.0485519434476131 no 249 0.0485198437470264 77 6620925 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.65241222039501 0.0492657118332324 no 250 0.0492252730091748 60 688667 SGTC_429 1112-0049 25.5 µM 1.6500645933381 0.0495081543437777 no 251 0.0494648627528026 78 2836170 SGTC_3101 9120531 49.47 µM 1.64834802698587 0.0496860283615116 no 252 0.0496406373047211 89 24824904 SGTC_3325 9138760 55.175 µM 1.64802885080102 0.049719158183884 no 253 0.0496733754906811 68 43844959 SGTC_1594 piperine 70.1 µM 1.64622052479525 0.0499071915733195 no 254 0.0498591825220178 64 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.63943808003198 0.0506175017320986 no 255 0.0505610282120924 85 551469 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.63702718567186 0.0508719206288148 no 256 0.050812394667561 79 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1619 st003326 88.7 µM 1.63644409595114 0.050933606053787 no 257 0.0508733383854702 61 2849032 SGTC_686 1319-0111 510 µM 1.63142607751915 0.0514669296424882 no 258 0.0514002230569677 101 4562600 SGTC_1179 1021-1431 9.29 µM 1.62984779878514 0.0516355868533444 no 259 0.0515668343229307 93 2840958 SGTC_996 3970-0799 1.8 µM 1.62383743699715 0.0522818892768678 no 260 0.0522052539034755 109 6615648 YGL040C HEM2 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.62288681406379 0.0523846968988575 no 261 0.0523068014088364 81 2333 A French combination drug. SGTC_3244 9134489 49.47 µM 1.62232436808592 0.0524455996360971 no 262 0.0523669568637217 91 16584271 SGTC_3200 9114385 49.47 µM 1.62194782251836 0.0524864041203192 no 263 0.0524072603426061 82 17018030 YLR208W SEC13 SGTC_2194 5927483 104.545 µM 1.62158941495752 0.0525252664787731 no 264 0.0524456452953102 58 760979 SGTC_3327 9140648 26.9345 µM 1.61989353616573 0.0527094614948421 no 265 0.0526275743029611 129 8029710 SGTC_746 1095-0025 46.6 µM 1.61945989963385 0.0527566423833302 no 266 0.0526741738976449 79 6749286 SGTC_689 0833-0039 98 µM 1.61830944050977 0.052881977989613 no 267 0.0527979635964828 76 5374726 SGTC_1410 3909-8106 77.9 µM 1.61639845645927 0.0530906901006994 no 268 0.0530040959413624 94 1039210 SGTC_1198 1612-1005 86.7 µM 1.61257285977082 0.0535104728555889 no 269 0.0534186694108876 97 6998509 SGTC_2284 7945075 39.21 µM 1.61242515123847 0.053526733492912 no 270 0.0534347277117385 86 1245402 SGTC_2358 9037157 4 µM 1.6052251672806 0.0543241079763118 no 271 0.0542221303884445 96 2388925 SGTC_2296 7971656 126.45 µM 1.59659577640369 0.0552921331834052 no 272 0.0551779205056103 66 666570 SGTC_583 1488-1091 88.9 µM 1.5955050716575 0.0554154496964066 no 273 0.0552996683903371 105 4303273 SGTC_1520 flindersine 88 µM 1.58935936354909 0.0561143553964771 no 274 0.0559896417230454 92 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2997 9067075 71.4286 µM 1.58526950284632 0.0565833042156191 no 275 0.056452557514391 106 27209819 SGTC_821 1114-0266 29.2 µM 1.58238477375918 0.0569159241589561 no 276 0.0567808792597084 81 3123235 SGTC_1338 1486-1223 76 µM 1.58144884248492 0.0570241706871983 no 277 0.0568877236176219 81 3444526 SGTC_2434 5670830 169.91 µM 1.58065428721693 0.057116193311 no 278 0.0569785529273312 87 1549830 SGTC_2187 6125751 200 µM 1.58004281909442 0.0571870909820864 no 279 0.0570485304117521 90 874498 SGTC_563 tetrahydrosecaminediol 614 µM 1.57973754913842 0.0572225119187303 no 280 0.0570834913525965 65 334274 A psychoactive constituent of the cannabis plant. SGTC_431 k089-0097 107 µM 1.57769147607022 0.0574603667743415 no 281 0.0573182527409351 98 5499420 SGTC_1215 3852-0577 11.2 µM 1.57662522266945 0.0575846260376826 no 282 0.0574408927852659 81 2884876 SGTC_2862 9027634 71.43 µM 1.57535269626054 0.0577332005060244 no 283 0.0575875283663314 93 5012562 SGTC_3080 9117754 49.47 µM 1.57367391421239 0.0579296684812005 no 284 0.0577814277540337 89 9550191 SGTC_331 k048-0133 24.5 µM 1.57208593982702 0.0581159925138153 no 285 0.0579653109039012 97 6813582 SGTC_1997 st073024 93.8 µM 1.57078045223255 0.0582695235451475 no 286 0.0581168270678411 79 686268 SGTC_739 1486-1183 203 µM 1.56843055990379 0.0585466838474468 no 287 0.0583903419050425 73 4346692 SGTC_308 4092-1169 104 µM 1.56779952347347 0.0586212880690303 no 288 0.0584639630804849 85 2268590 YDL196W YDL196W SGTC_1488 4013-0813 75.9 µM 1.5651441142124 0.0589360416490339 no 289 0.0587745609288708 76 2910057 SGTC_3202 9113761 49.47 µM 1.5642486737472 0.0590424793276308 no 290 0.0588795902804154 106 4798415 SGTC_1758 st042942 75.2445 µM 1.56228980007984 0.0592758490775224 no 291 0.0591098668980471 91 669317 SGTC_1933 st074711 15.9 µM 1.55914182197411 0.0596523967829522 no 292 0.0594814084818646 117 17250958 SGTC_1618 st003135 44.5 µM 1.55811486945793 0.0597756411105561 no 293 0.0596030102296874 90 1270615 SGTC_790 1575-0012 79.1 µM 1.55563031254723 0.060074637312537 no 294 0.0598980131683313 90 378741 YLR208W SEC13 SGTC_3300 9124615 50.48 µM 1.5551026025854 0.0601382934337411 no 295 0.0599608176159341 71 24824903 SGTC_1098 clofazimine 15.1 µM 1.55062981275015 0.0606799558523681 no 296 0.0604952116888069 116 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1452 4194-0072 190 µM 1.54495211466696 0.0613730223133891 no 297 0.0611789232060654 99 1343545 SGTC_1061 3448-9325 110 µM 1.54015572473072 0.0619633143908603 no 298 0.061761199640848 104 723482 SGTC_3204 9114183 49.47 µM 1.53964412664082 0.0620265374151846 no 299 0.0618235615667483 96 17027248 SGTC_93 0109-0045 59.227 µM 1.53912020263406 0.0620913358272885 no 300 0.0618874769074785 114 88733 SGTC_1457 k015-0032 57.3 µM 1.53804368333356 0.0622246444274746 no 301 0.0620189671412235 82 4302660 SGTC_2798 7813637 45.45 µM 1.53737890107322 0.062307077832286 no 302 0.0621002750297603 121 956368 SGTC_2896 9052656 71.43 µM 1.53645834721786 0.0624213676662259 no 303 0.0622130030020819 132 6469436 SGTC_1170 0310-0127 64.8 µM 1.53586522110093 0.0624950928029763 no 304 0.062285719771626 105 774975 SGTC_590 k048-0076 22.4 µM 1.52836549416744 0.0634331699865231 no 305 0.0632109085301018 98 6832814 SGTC_1109 tnp00067 928.257 nM 1.52768205389207 0.063519197723084 no 306 0.0632957489804197 74 676295 SGTC_1187 1391-0724 117 µM 1.52173401957636 0.0642717423347543 no 307 0.0640378699026297 88 6997986 SGTC_1803 st050068 52.4 µM 1.5204503716269 0.0644350547728687 no 308 0.0641989114012574 98 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_696 1560-0013 611 µM 1.51818391071797 0.0647241928267413 no 309 0.0644840211763855 104 1650269 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.51745761460116 0.064817061091169 no 310 0.0645755935261586 85 6710655 SGTC_2373 9071805 200 µM 1.51692616750834 0.0648850804000055 no 311 0.0646426630341717 86 10149009 SGTC_2629 bisabolol 100 µM 1.51688388682377 0.0648904942355766 no 312 0.0646480012494971 131 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2699 st077704 54.6 µM 1.51571262169413 0.0650406084861961 no 313 0.0647960173557841 84 645852 SGTC_1036 k216-0215 33.5 µM 1.50931078770175 0.0658658616026988 no 314 0.0656096895921525 81 622330 SGTC_1250 0485-0349 40.2 µM 1.50832712947077 0.0659933799641978 no 315 0.0657354115398113 91 6842794 YDL195W SEC31 SGTC_1931 st074438 57.1 µM 1.50712364649538 0.0661496558082166 no 316 0.0658894833405099 130 2787313 SGTC_2305 7443522 69.23 µM 1.50675849742807 0.0661971281401054 no 317 0.0659362855985496 112 5415886 SGTC_2628 lathosterol 100 µM 1.50593263709274 0.0663045939921633 no 318 0.0660422336287253 100 6710616 SGTC_3076 9116187 49.47 µM 1.50311701029683 0.0666719957798198 no 319 0.0664044365425692 76 27241210 SGTC_128 0906-2981 13.371 µM 1.50203403392218 0.0668137285830336 no 320 0.066544159747858 121 6740226 SGTC_965 1291-5240 308 µM 1.5017129502584 0.0668557946672621 no 321 0.0665856289569836 96 2834598 SGTC_2174 5790901 200 µM 1.49289710948735 0.0680188056409292 no 322 0.0677320609484025 104 786020 SGTC_1632 st005650 90 µM 1.4887734549348 0.06856814395832 no 323 0.068273517318108 104 2759605 SGTC_661 1304-0007 33.6 µM 1.48288602575399 0.0693583685553561 no 324 0.0690523474102435 107 3117130 SGTC_1998 st075797 76.8 µM 1.47631288180615 0.0702488990362824 no 325 0.069929958779451 99 24208315 SGTC_792 4534-1957 155 µM 1.47113706992301 0.0709562863482365 no 326 0.0706270258363731 83 1717904 SGTC_3182 9108849 49.47 µM 1.47092778278747 0.0709850046624523 no 327 0.0706553240995966 89 17133045 SGTC_1124 fisetin 1.16336 µM 1.46541071596773 0.0717452786295991 no 328 0.0714044477705766 95 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_221 trifluoperazine 10.304 µM 1.46407765657559 0.0719299131245035 no 329 0.0715863657022351 129 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2716 st080858 38.6235 µM 1.46283704584103 0.0721020701982233 no 330 0.071755986763194 85 5296050 SGTC_2543 pimpinellin 60.67 µM 1.45759677164397 0.0728327390930455 no 331 0.07247586001375 99 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1194 1488-0194 225 µM 1.45718005507289 0.0728910857155753 no 332 0.0725333423259337 91 1391452 SGTC_263 alizarin 107.927 µM 1.45607171203164 0.0730464446467434 no 333 0.072686398264376 139 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_219 mitoxanthrone 164.414 µM 1.4536787962347 0.0733827290644336 no 334 0.0730176897571693 105 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1141 3253-0389 52.6 µM 1.4513525935846 0.0737107718766564 no 335 0.0733408515964627 113 5402031 SGTC_3185 9108267 49.47 µM 1.45061941453176 0.0738143973252875 no 336 0.0734429330690828 98 4910486 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.45039232145949 0.0738465165900403 no 337 0.0734745735637197 117 442882 SGTC_297 0986-0032 24 µM 1.44958710439158 0.0739604898130553 no 338 0.0735868471136365 113 2847425 SGTC_1674 st016616 23.6 µM 1.44949974261149 0.0739728633809199 no 339 0.0735990360817191 92 625830 SGTC_2486 5283202 22.39 µM 1.44930158947728 0.0740009348488038 no 340 0.0736266887011874 96 1377751 SGTC_2485 5633444 17.78 µM 1.44796605596361 0.0741903462385024 no 341 0.0738132719845479 106 5724239 SGTC_517 1365-0151 113 µM 1.44531809296939 0.0745669869189072 no 342 0.0741842790408879 94 768657 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.4428646861895 0.0749172552536155 no 343 0.0745292963642268 125 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_886 0866-0150 153 µM 1.4419321724578 0.0750507171997568 no 344 0.0746607545429594 103 271463 SGTC_2279 7948423 32.93 µM 1.44094619675861 0.0751920277883699 no 345 0.0747999417384761 92 1247112 SGTC_1948 st076329 66.6 µM 1.44083873991754 0.0752074408141375 no 346 0.0748151230505581 78 24208413 SGTC_618 k072-0232 33.2 µM 1.44048659719446 0.0752579671355248 no 347 0.0748648896252022 119 5872756 YGL099W LSG1 SGTC_2271 7849410 118.62 µM 1.43834144697558 0.0755663178103922 no 348 0.0751685986749288 102 972430 SGTC_605 1315-0399 119 µM 1.43752809702813 0.0756834826661773 no 349 0.0752839975664589 129 24020461 SGTC_1800 st050079 29.0735 µM 1.43422830991929 0.076160244280738 no 350 0.075753560378091 129 3645560 SGTC_700 3453-2283 142 µM 1.43199948720847 0.0764835614654198 no 351 0.0760719840362493 103 565664 SGTC_840 0245-0196 390 µM 1.42800208285493 0.0770660465667135 no 352 0.0766456295064436 108 3827528 SGTC_528 3492-0019 172 µM 1.42737916100088 0.0771571189488382 no 353 0.0767353170869525 130 2869262 SGTC_981 1488-1094 54.9 µM 1.42570913546515 0.0774016834165288 no 354 0.0769761592225384 94 3449522 SGTC_1380 2291-0730 164 µM 1.4230856829959 0.0777870594071584 no 355 0.0773556590862844 97 2999191 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.42001976764237 0.0782392751350753 no 356 0.0778009631072668 123 5024745 SGTC_702 1488-0190 94 µM 1.41686734312028 0.0787063269232114 no 357 0.0782608579916878 69 949357 SGTC_1123 mangostin 811.285 nM 1.4156625325282 0.0788853842733481 no 358 0.0784371666129232 61 5281650 An antioxidant. SGTC_2006 4011487 200 µM 1.41322859208533 0.0792480544534697 no 359 0.0787942610919319 134 45595294 SGTC_1596 piperlongumine 63 µM 1.40942184645377 0.0798178090550492 no 360 0.0793552339744335 91 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1032 k061-1018 98.7 µM 1.40873830871302 0.0799204412478257 no 361 0.0794562814058913 94 4005393 SGTC_1855 st056195 39.6 µM 1.4070839278957 0.0801692571342738 no 362 0.0797012516644607 102 4028379 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.40398594883164 0.0806367617519945 no 363 0.0801615168844325 116 688662 SGTC_1600 coumarin 106 71.1 µM 1.40057679223187 0.0811536014366392 no 364 0.0806703324590028 112 100336 A hepatotoxic, DNA x-linker. SGTC_526 4469-0568 170 µM 1.39913740164485 0.0813725669061422 no 365 0.0808858919007412 108 2901964 SGTC_1301 naphtanilide LB 4.81 µM 1.3968820148508 0.0817165605397167 no 366 0.0812245269109922 130 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.3952261428123 0.0819698126902455 no 367 0.0814738279455133 124 616764 SGTC_1229 0139-0193 12.2 µM 1.38604709567584 0.0833844089826657 no 368 0.0828662615951639 132 3090752 SGTC_495 decylubiquinone 155 µM 1.38480038612874 0.0835779480945615 no 369 0.0830567564246948 108 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.38403515645904 0.083696909362631 no 370 0.0831738450602726 124 688788 SGTC_2312 7706453 155.7 µM 1.38351942268771 0.0837771561600939 no 371 0.0832528280388852 118 976098 SGTC_1220 1838-0075 193 µM 1.38149542873524 0.0840926427199454 no 372 0.0835633411957932 100 5529645 SGTC_3009 9080819 71.4286 µM 1.38048364689841 0.0842506864513081 no 373 0.0837188906483692 118 17027216 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.37796550394051 0.0846449965784534 no 374 0.0841069694740035 102 97141 SGTC_71 0417-1750 47.813 µM 1.37794220802479 0.0846486508820854 no 375 0.0841105659738451 102 6811472 SGTC_1310 1188-0297 994 nM 1.37678836311247 0.0848297963630947 no 376 0.084288844841802 122 1588352 SGTC_515 4092-1064 102 µM 1.37552960800808 0.0850277433200887 no 377 0.0844836565022888 133 717353 SGTC_1710 st031758 61.5 µM 1.36203484502848 0.0871716731908394 no 378 0.0865934443284422 114 5394341 SGTC_685 1278-0033 54.9 µM 1.35702857748498 0.0879772074667987 no 379 0.0873860652138083 123 3590572 SGTC_1708 st033234 31.827 µM 1.35580046047731 0.0881756630444305 no 380 0.0875813323857257 120 674664 SGTC_1672 st016598 6.51 µM 1.35294293426684 0.0886387115869144 no 381 0.0880369309004275 137 4665860 YNL267W PIK1 SGTC_830 4076-0286 57.8 µM 1.34777686838767 0.0894804410988778 no 382 0.0888650799725481 125 6866659 SGTC_676 falcarinol 140 µM 1.34700455528571 0.0896067865360009 no 383 0.0889893827896741 123 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2939 9044578 71.43 µM 1.34625436512151 0.0897296397649642 no 384 0.0891102488219522 116 2653634 SGTC_1637 st007924 17.4 µM 1.34216622061887 0.090401326863955 no 385 0.0897710532030884 102 683336 SGTC_2767 sibutramine 71.45 µM 1.34115013159769 0.0905688493582901 no 386 0.089935856795198 98 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1830 st055982 50.3 µM 1.33674007819114 0.0912986055746936 no 387 0.0906537473960667 117 455313 An antimicrobial agent. SGTC_361 000s-0510 1.45 µM 1.33227141972398 0.0920424969986081 no 388 0.0913855075801382 109 660 SGTC_905 2-aminofluorene 215 µM 1.33092458100173 0.092267581159423 no 389 0.0916069140729762 112 1539 An established DNA mutagen. YPR165W RHO1 SGTC_368 fentichlor 4.58 µM 1.32550264167653 0.0931778193836335 no 390 0.0925022469185504 117 7329 A pesticide. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.3203889426642 0.0940423747210041 no 391 0.093352596721886 136 688798 SGTC_161 4065-0411 162.148 µM 1.31936213506816 0.0942166848216374 no 392 0.0935240371120712 129 1906281 YLR208W SEC13 SGTC_3002 9075603 71.4286 µM 1.31796174364555 0.0944547982385735 no 393 0.093758227389451 133 20105405 SGTC_3315 9136395 68.55 µM 1.31747701461089 0.0945373216882651 no 394 0.0938393903779287 160 16876844 SGTC_3215 9129942 49.47 µM 1.31424446570254 0.0950890115701614 no 395 0.0943819745787513 124 17682944 SGTC_2053 5265679 138 µM 1.31340429119023 0.0952327892314065 no 396 0.0945233761495723 137 764595 SGTC_419 nsc-638432 893 µM 1.3113050722173 0.0955927245930023 no 397 0.0948773577129763 119 368090 SGTC_2934 9036370 36.88 µM 1.31109275874348 0.0956291838619202 no 398 0.0949132134650599 105 6462800 SGTC_433 pimozide 108 µM 1.30903965904827 0.0959822778797034 no 399 0.0952604585520981 101 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2309 7664088 163.95 µM 1.30897291348513 0.0959937729137143 no 400 0.0952717630485602 130 704922 SGTC_152 4469-0003 551.229 µM 1.30896741750774 0.0959947194853637 no 401 0.095272693929829 156 697280 SGTC_1556 plumbagin 1.48 µM 1.30877711815622 0.0960274989576197 no 402 0.0953049300164573 135 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1864 st057645 30.4 µM 1.30574918636186 0.0965501745486735 no 403 0.0958189326311106 129 688666 SGTC_1104 tacrolimus 29.8 µM 1.30163090231164 0.0972644148334796 no 404 0.0965212953458574 133 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2504 purpurogallin 52.29 µM 1.29945776314968 0.0976428646653889 no 405 0.0968934397052029 113 5281571 An antioxidant. SGTC_2917 7979103 53.79 µM 1.29710789698674 0.0980533050997209 no 406 0.097297032374357 111 2980565 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.2920004044773 0.0989497646885351 no 407 0.098178502258517 122 756377 SGTC_2821 7996764 71.43 µM 1.29096605531703 0.0991320399344976 no 408 0.0983577241592999 110 2987135 SGTC_1013 4112-3890 241 µM 1.28152267621637 0.100807538433008 no 409 0.10000507012277 131 705171 SGTC_327 1273-0057 3.96 µM 1.28151899968009 0.100808194741957 no 410 0.100005715374163 116 3108138 SGTC_506 n9-isopropylolomoucine 153 µM 1.28061205759327 0.100970190755755 no 411 0.100164981355178 100 6610355 SGTC_1663 st014140 55.4 µM 1.27903714972348 0.101251948111976 no 412 0.10044198705386 120 4207120 SGTC_2837 9008476 45.46 µM 1.27716564507316 0.101587512180119 no 413 0.100771886526732 109 2992805 SGTC_3304 9125678 46.087 µM 1.27699478106809 0.101618188692368 no 414 0.100802044896242 145 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2101 5377231 179.231 µM 1.27519349896851 0.10194199700924 no 415 0.101120380884717 143 2844213 SGTC_2920 7982904 15.77 µM 1.27497223297021 0.101981824722364 no 416 0.101159535131864 139 6456808 SGTC_177 1327-0068 8.361 µM 1.2695477446919 0.10296177271048 no 417 0.102122886615177 144 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2555 cholic acid 100 µM 1.26936543121259 0.102994826524186 no 418 0.102155379757854 99 6708657 Influences liver metabolism. SGTC_3308 9128332 17.569 µM 1.26785566697211 0.103268846184033 no 419 0.102424749232131 128 17332805 YDL196W YDL196W SGTC_598 3937-0236 20.2 µM 1.2658617260861 0.103631553737851 no 420 0.102781295634629 135 1379313 SGTC_373 0844-0104 25.9 µM 1.26554401216952 0.103689432719837 no 421 0.102838190832256 146 5375804 SGTC_1219 1469-0211 33.1 µM 1.2651776578764 0.10375620178804 no 422 0.102903824797704 137 6822282 SGTC_911 3456-4043 236 µM 1.25492935520411 0.105636640150615 no 423 0.104752203204871 128 914281 SGTC_2840 9008771 71.43 µM 1.25431525895684 0.105750096807113 no 424 0.104863719929851 82 2992978 SGTC_1303 1160-0052 261 µM 1.25136801544264 0.106295837414786 no 425 0.105400120492071 115 3562476 SGTC_2229 7354935 190 µM 1.24855809791192 0.106818040727202 no 426 0.105913373154712 157 318112 SGTC_125 0133-0007 11.75 µM 1.24426300769202 0.107619826049311 no 427 0.106701390498267 133 26541 SGTC_462 ag-879 158 µM 1.24151396106254 0.108135274590002 no 428 0.10720797198685 150 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1188 1403-0014 4.57 µM 1.24018361373107 0.108385352965642 no 429 0.107453743915998 126 9614867 SGTC_199 4063-0024 41.6 µM 1.23917784794428 0.108574692626151 no 430 0.107639821152857 92 306215 SGTC_2351 9026858 72.31 µM 1.237230242315 0.108942013820732 no 431 0.108000808510393 148 1409300 SGTC_511 blebbistatin 171 µM 1.23667116939297 0.109047620602048 no 432 0.108104593138142 130 3476986 A myosin inhibitor. SGTC_1910 st062352 60.4 µM 1.23588635915697 0.10919599242579 no 433 0.108250404076506 119 2245730 SGTC_292 k038-0015 474 µM 1.23246927540782 0.109843697836053 no 434 0.108886918475811 134 46368540 SGTC_471 1-acyl-paf 4 µM 1.23011126783023 0.110292261216696 no 435 0.109327720572563 128 16759367 SGTC_3349 9149703 23.001 µM 1.2291980883837 0.110466327584282 no 436 0.10949877273923 120 4910494 SGTC_658 3253-0951 102 µM 1.22831732407799 0.110634401619673 no 437 0.109663935066629 150 1184878 SGTC_2096 5468907 200 µM 1.22539567270746 0.111193245155503 no 438 0.110213088283379 126 759785 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.2244574666324 0.111373130026106 no 439 0.110389851054193 130 75037 A free radical scavenger. SGTC_908 3448-7491 47.7 µM 1.22442795849977 0.111378791079495 no 440 0.110395413830927 129 1203031 SGTC_163 TUB2.036 7.546 µM 1.22303114538762 0.111647001468223 no 441 0.110658966458036 179 15992207 YJR013W GPI14 SGTC_656 4090-1979 187 µM 1.21603124143104 0.112998055025942 no 442 0.111986510598234 141 22330961 SGTC_105 0111-0055 734.78 µM 1.21405436211909 0.113381717481765 no 443 0.112363482937662 120 5179370 SGTC_85 0868-0259 160.055 µM 1.21370414075161 0.11344978338645 no 444 0.112430361300123 133 83173 SGTC_2580 diallyl disulphide 81.36 µM 1.21269218052484 0.113646622693257 no 445 0.112623765277026 141 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.2124650186156 0.113690842053165 no 446 0.112667212679046 143 91467 include heat shock SGTC_1515 3460-0031 42.1 µM 1.21225833403864 0.113731085948472 no 447 0.112706753947553 143 2876596 SGTC_2265 7929201 200 µM 1.21132866093391 0.113912229687196 no 448 0.112884734229301 170 1265108 SGTC_2293 7624732 200 µM 1.20877879637924 0.114410117318817 no 449 0.113373919894265 130 894453 SGTC_993 3909-8757 62.7 µM 1.20683022239106 0.114791639645796 no 450 0.113748767203942 118 4288324 YLR208W SEC13 SGTC_713 1488-1073 324 µM 1.20491084366183 0.115168329710906 no 451 0.114118861008532 135 3312542 SGTC_3313 9133968 57.047 µM 1.20464824527975 0.115219934548464 no 452 0.114169561742815 134 1494643 SGTC_2078 5212016 200 µM 1.20135574511843 0.115868359667823 no 453 0.114806617543664 132 1899708 SGTC_1078 idebenone 36.1 µM 1.19720877044294 0.11668874655493 no 454 0.115612596124458 170 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2379 9035213 200 µM 1.19513399984801 0.117100736033986 no 455 0.116017339984479 153 646551 SGTC_955 1216-0110 33 µM 1.19506368903941 0.117114715760461 no 456 0.116031073735475 132 3619719 SGTC_2870 9038528 12.99 µM 1.19419313656049 0.117287903545645 no 457 0.116201213628925 134 6463316 SGTC_2198 6589944 200 µM 1.19335713409704 0.117454388614013 no 458 0.11636476767653 125 5290268 SGTC_794 k038-0031 316 µM 1.19285721167779 0.117554025192973 no 459 0.116462649614035 137 6624242 SGTC_1362 1611-0397 101 µM 1.19100524196009 0.117923651685592 no 460 0.116825763516566 147 27816 SGTC_1353 1498-1206 8.11 µM 1.18863339211042 0.118398238605018 no 461 0.117291980901953 140 6756808 SGTC_1729 st035615 45.989 µM 1.18688316490858 0.118749308780395 no 462 0.117636854353715 149 17385451 SGTC_2148 5546263 113.568 µM 1.18654731269605 0.118816759868996 no 463 0.117703114337971 141 792097 SGTC_2863 9028737 58.44 µM 1.18577085258489 0.118972804313421 no 464 0.117856402576893 134 6460917 SGTC_2835 9006588 71.43 µM 1.18386222332734 0.119356994620754 no 465 0.118233803096962 114 2345538 SGTC_1281 0884-0031 11.8 µM 1.1835670651799 0.119416485437128 no 466 0.118292242045495 150 1548255 SGTC_827 3253-0474 693 µM 1.18292218535863 0.119546537446159 no 467 0.118419994127691 145 5402065 SGTC_40 0327-0103 19.753 µM 1.18250832465231 0.11963005277122 no 468 0.118502032184045 131 409036 SGTC_1900 st060200 72.8 µM 1.1820841704867 0.119715687962649 no 469 0.118586152343679 153 688945 SGTC_3345 9148410 3.559 µM 1.18140832312446 0.119852228403037 no 470 0.118720276596943 147 4903596 SGTC_3214 9129694 49.47 µM 1.17928651661254 0.120281607135964 no 471 0.119142052719433 162 17158655 SGTC_1222 0366-0074 1.18 µM 1.17903589765312 0.120332395036774 no 472 0.119191940923697 158 286520 SGTC_2977 9011197 71.43 µM 1.1771119064197 0.120722794783586 no 473 0.119575421718982 158 2704722 SGTC_257 daunorubicin 18.5 µM 1.17658503705185 0.120829857918658 no 474 0.119680586445784 143 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1700 st030840 7.9285 µM 1.1761779200868 0.12091263237563 no 475 0.119761892892226 169 5499307 SGTC_675 1309-0189 238 µM 1.17426748721468 0.121301591876618 no 476 0.120143950901247 135 4246530 SGTC_465 cgp-37157 41 µM 1.17383625542905 0.12138951120699 no 477 0.120230309493335 121 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1402 3909-7673 35.9 µM 1.17169203717764 0.121827338625462 no 478 0.120660360568313 140 5328014 SGTC_2472 5377652 49.4 µM 1.17114351448214 0.121939519327971 no 479 0.120770547722852 169 1610903 SGTC_2131 toluylene red 5.2905 µM 1.16529645802111 0.123139835766835 no 480 0.12194950617825 134 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1655 st012546 55.1 µM 1.16339338266513 0.123532290055322 no 481 0.122334966568515 127 720985 YLR208W SEC13 SGTC_439 amiodarone 34.4 µM 1.16124064832761 0.123977284253619 no 482 0.122772024262965 146 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_352 k048-0007 5.11 µM 1.16089768501077 0.124048282062124 no 483 0.12284175520543 183 6811911 SGTC_82 0054-0107 293.755 µM 1.16039268982598 0.124152874325033 no 484 0.122944480844827 141 3104697 SGTC_565 1418-0001 44.5 µM 1.16023215313833 0.12418613686019 no 485 0.122977149677998 148 2862145 SGTC_126 0417-1624 672.48 µM 1.15841857225005 0.124562336343407 no 486 0.123346631826553 201 41912 YDL195W SEC31 SGTC_357 1325-0123 420 µM 1.1582073434174 0.124606204262467 no 487 0.123389716144323 153 1098503 SGTC_173 1273-0061 2.693 µM 1.15678616561659 0.124901634661917 no 488 0.12367986769384 172 2847414 YPL266W DIM1 SGTC_3047 9092122 49.47 µM 1.15612055585711 0.125040167861221 no 489 0.123815924547136 151 17173831 SGTC_1907 st060210 83.7 µM 1.15499640358184 0.125274381024835 no 490 0.124045949612292 164 688793 SGTC_2022 5136654 200 µM 1.15400922321459 0.12548030901565 no 491 0.124248193811228 173 1713771 SGTC_1742 st038235 28.8875 µM 1.15370272823208 0.125544292576191 no 492 0.124311032506264 169 564103 YBR002C RER2 SGTC_3127 9126946 49.47 µM 1.15189370127266 0.125922406845286 no 493 0.12468237843027 141 27243249 SGTC_1142 3253-1408 9.78 µM 1.14886848781721 0.126556495722563 no 494 0.125305106657058 154 256655 SGTC_2991 9074669 71.4286 µM 1.14795478203372 0.126748446268989 no 495 0.125493615601429 193 17333109 SGTC_1280 0880-0253 10.1 µM 1.14770886019531 0.126800143928519 no 496 0.125544386142095 154 6836607 SGTC_497 capsazepine 133 µM 1.14287497314142 0.127819304384696 no 497 0.126545252417232 140 2733484 A calcium channel blocker. SGTC_3108 9121785 49.47 µM 1.14250939460564 0.127896612623242 no 498 0.126621171637456 154 17140271 SGTC_768 0384-0033 77.3 µM 1.14045767683126 0.12833108853285 no 499 0.12704783778381 152 3965305 YMR134W ERG29 SGTC_2879 9041815 71.43 µM 1.14002618987067 0.128422591350788 no 500 0.127137695090158 108 4942971 SGTC_543 3844-1095 191 µM 1.13921988460149 0.128593700982001 no 501 0.127305726942394 193 4230703 SGTC_2820 7989630 71.43 µM 1.13558971372288 0.129366035069034 no 502 0.128064157915087 106 2984098 SGTC_3341 9147222 25.867 µM 1.13393433225891 0.129719289442248 no 503 0.128411047256514 163 1939759 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.1339200642882 0.129722337093445 no 504 0.128414039978201 117 6708630 An antioxidant. SGTC_446 go6976 132 µM 1.12965678240953 0.130635199689859 no 505 0.129310437250221 148 3501 A protein kinase C inhibitor. SGTC_2742 clothiapine 36.27 µM 1.12877197251011 0.130825212177956 no 506 0.129497019421675 106 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_714 4296-0578 26.1 µM 1.12824695049807 0.130938050653181 no 507 0.129607820317241 163 1589775 SGTC_2302 7771753 200 µM 1.12630154787716 0.131356745527975 no 508 0.13001895141271 156 2203047 SGTC_796 1234-0020 70.7 µM 1.12572590145523 0.131480814774682 no 509 0.130140778367907 146 46495034 SGTC_2243 6634756 200 µM 1.1231330141327 0.13204066325162 no 510 0.130690503321179 124 885676 SGTC_2642 cholecalciferol 100 µM 1.12176526546982 0.132336644823338 no 511 0.13098112920187 135 9821465 A vitamin D precursor, similar to steriods. SGTC_342 k048-0088 23.3 µM 1.12058383790543 0.132592674235331 no 512 0.131232523868344 163 6820570 SGTC_2117 5521686 200 µM 1.11997093056708 0.132725632899489 no 513 0.131363074942828 154 803312 SGTC_1974 st069448 26.9 µM 1.11902845511215 0.132930264254424 no 514 0.131563999916188 142 6323587 YNR016C ACC1 SGTC_148 3253-0744 288.01 µM 1.1180234153511 0.133148718849407 no 515 0.13177849648165 147 6893655 SGTC_129 0088-0017 176.636 µM 1.11792005056862 0.133171200135067 no 516 0.131800570369798 140 182446 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.11508812419045 0.133788145241119 no 517 0.132406330037036 143 6708514 SGTC_384 k007-0144 5.16 µM 1.11213564974917 0.134433441065129 no 518 0.133039915393132 179 6824886 SGTC_529 4076-0302 30.3 µM 1.10961028332885 0.134987080717116 no 519 0.133583499042409 158 5816522 SGTC_294 k038-0071 157 µM 1.10792157191703 0.135358170650018 no 520 0.133947844177521 170 24152826 SGTC_62 0180-0423 3.232 µM 1.10765204794888 0.135417462482788 no 521 0.134006058009034 187 30102 YGL099W LSG1 SGTC_3045 9092950 49.47 µM 1.1075752361816 0.135434363349842 no 522 0.134022651579931 140 44120432 SGTC_998 3996-0085 177 µM 1.1060929883581 0.135760784942703 no 523 0.134343136628702 157 715391 SGTC_1285 0929-0069 65.5 µM 1.09522916314649 0.138169668141541 no 524 0.136708126139388 140 1206237 SGTC_2176 5809774 33.9695 µM 1.09312825505019 0.138638854029057 no 525 0.137168745922129 135 2870539 SGTC_164 4100-3994 89.624 µM 1.09128837428405 0.139050636415018 no 526 0.137573005843244 186 4615967 SGTC_1429 4049-0205 9.46 µM 1.08969258198981 0.139408463106051 no 527 0.137924292428838 148 22774478 SGTC_95 0471-0001 561.058 µM 1.08724919474221 0.139957560055112 no 528 0.138463347450757 169 4015405 SGTC_1322 1348-1070 12 µM 1.08445360484471 0.140587607285873 no 529 0.139081863606152 174 6758089 SGTC_1290 0986-0249 10.2 µM 1.08140389083846 0.141277119437865 no 530 0.139758745832707 162 53329 SGTC_848 0368-0089 85.6 µM 1.07844451288438 0.141948395571223 no 531 0.140417715668763 169 762535 SGTC_2077 5212015 200 µM 1.07595247215219 0.142515337795732 no 532 0.140974256443001 161 780900 SGTC_2712 st079126 47.7 µM 1.07251318966956 0.143300290735898 no 533 0.141744796470282 165 3152970 SGTC_1962 st076595 64.5 µM 1.07179859077668 0.143463750429491 no 534 0.141905253108597 179 279619 SGTC_531 3788-1495 174 µM 1.07153589878829 0.143523871086034 no 535 0.141964269092718 149 2896655 SGTC_2010 4012422 159 µM 1.07139871999488 0.143555273088785 no 536 0.14199509407597 164 952393 SGTC_2491 paeonol 100 µM 1.06983638707036 0.14391323850837 no 537 0.14234648029452 160 11092 Increases levels of cortical cytochrome oxidase. SGTC_2810 7959871 45.46 µM 1.06874560701465 0.144163517254852 no 538 0.142592157431457 179 2974535 SGTC_1019 4262-0212 3.4 µM 1.06827585549747 0.144271391773265 no 539 0.142698048164778 189 4677213 SGTC_2958 9077254 16.72 µM 1.06441164246858 0.145160840637959 no 540 0.143571130952032 160 16457351 SGTC_1394 3474-0001 65.7 µM 1.06427701591422 0.145191894809447 no 541 0.143601613420761 130 5017666 YIL048W NEO1 SGTC_1401 3807-4679 7.6 µM 1.06423075713509 0.145202566307232 no 542 0.143612088453218 182 3291456 SGTC_2345 9052315 157.45 µM 1.06250697768526 0.145600603513702 no 543 0.144002796001827 163 6469265 SGTC_1125 tnp00248 1.32998 µM 1.06220557833758 0.145670274796312 no 544 0.144071183987316 188 24207736 SGTC_404 fumagillin 50 µM 1.06102484578274 0.1459434280503 no 545 0.144339304989409 175 12015870 A methionine aminopeptidase binder. SGTC_2710 st078562 53.7235 µM 1.05908747467762 0.14639236896363 no 546 0.144779971856844 176 17250908 SGTC_1431 4049-0260 9.09 µM 1.05711951695816 0.146849345911502 no 547 0.145228522492674 187 3854841 SGTC_1588 farnesol 29.9 µM 1.05570920522366 0.147177420570115 no 548 0.145550545138745 167 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_43 0570-0105 72.5 µM 1.05143136428514 0.148175559678281 no 549 0.146530258544609 158 1114046 YDL195W SEC31 SGTC_968 1309-0633 340 µM 1.05029544910711 0.148441359498142 no 550 0.146791148437476 182 3761976 SGTC_1845 st056753 3.01 µM 1.04441916441746 0.149821476824288 no 551 0.148145750389706 157 5375839 SGTC_1041 0206-0046 107 µM 1.04330279944316 0.150084633124847 no 552 0.148404037481211 171 50494 SGTC_2831 7999036 19.48 µM 1.04229562551976 0.150322314510477 no 553 0.148637319934186 176 2988270 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.0414091927455 0.150531709794179 no 554 0.148842838944705 193 1273210 SGTC_2336 9001819 198.65 µM 1.04079408274608 0.150677126692266 no 555 0.148985563454998 212 2989602 SGTC_1079 idarubicin 2.36 µM 1.04028699520008 0.150797076545321 no 556 0.149103292154938 206 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2308 7584454 197.62 µM 1.04009704932886 0.150842023964193 no 557 0.149147407200283 178 893577 SGTC_208 k072-0098 12.366 µM 1.03700409399306 0.15157517350722 no 558 0.149866974591098 181 5948901 SGTC_35 0133-0054 64.071 µM 1.03598146459191 0.15181809627213 no 559 0.150105394934084 183 99677 SGTC_3187 9109394 49.47 µM 1.03462338099399 0.152141104923237 no 560 0.150422415226198 193 17098090 SGTC_445 e6 berbamine 66 µM 1.03454325300056 0.15216017693234 no 561 0.150441133596693 189 6610268 A calcium/calmodulin antagonist. SGTC_2884 9058502 51.95 µM 1.03349538963252 0.152409734765436 no 562 0.150686063478751 164 6471554 SGTC_236 1509-0011 5.31 µM 1.03244340947397 0.152660546150809 no 563 0.150932222587922 214 3107280 SGTC_620 0109-0052 432 µM 1.03240592069122 0.15266948921463 no 564 0.150940999747842 188 493037 SGTC_945 3381-0768 11.3 µM 1.03240341236383 0.152670087596207 no 565 0.150941587028719 180 1126236 YIL048W NEO1 SGTC_2600 tangeritin 87.95 µM 1.03199517821318 0.152767495852449 no 566 0.151037188162831 194 68077 A bioactive flavone. SGTC_2916 7875993 68.79 µM 1.02631953145696 0.154126024735776 no 567 0.152370496917694 187 1299250 SGTC_3056 9094900 49.47 µM 1.02446221888319 0.154572323274922 no 568 0.152808503579487 184 25236784 SGTC_3320 9137005 35.139 µM 1.02440132024071 0.154586971218014 no 569 0.15282287932037 189 4908713 SGTC_2624 nerol 100 µM 1.02291264932712 0.154945326363255 no 570 0.153174574086077 187 637566 A natural product oil. SGTC_1739 st037196 92.5 µM 1.01914108852146 0.155855676171573 no 571 0.154067994948195 156 612214 SGTC_1664 st014217 9.02 µM 1.01801545516349 0.156128054605838 no 572 0.154335305677506 189 3982782 SGTC_626 0214-0009 33 µM 1.01780679843256 0.156178579370067 no 573 0.154384890282471 184 3437874 SGTC_3105 9121040 49.47 µM 1.01695733467514 0.156384382251241 no 574 0.154586863198622 155 41448907 SGTC_1140 3229-1848 2.98 µM 1.01024796629718 0.158016160856184 no 575 0.156188251860872 178 2849525 SGTC_2744 captopril 92.04 µM 1.00985026340139 0.15811323544449 no 576 0.156283517300173 121 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1662 st014054 52 µM 1.0088540747538 0.158356565137904 no 577 0.156522311528518 176 2838777 SGTC_321 4534-3890 65.3 µM 1.00765007511074 0.15865098260796 no 578 0.156811240150228 192 699746 SGTC_1809 st050081 57.6 µM 1.0070164784426 0.15880606185198 no 579 0.156963427737034 199 5036894 SGTC_34 0469-0683 81.75 µM 1.00637925079359 0.1589621300013 no 580 0.157116585441736 158 3690923 SGTC_642 0335-0876 158 µM 1.00575075667972 0.159116157571511 no 581 0.157267740280505 194 6812350 SGTC_2847 9005661 71.43 µM 1.00475342419272 0.159360778442753 no 582 0.157507798094602 134 2991449 SGTC_1316 1272-0050 65.9 µM 1.00461296265804 0.159395249937856 no 583 0.157541626504668 194 7340392 SGTC_1077 5-fluorocytosine 377 nM 1.00457171979553 0.159405372519538 no 584 0.157551560240744 209 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3024 9090631 49.47 µM 1.00226666902532 0.159971789550585 no 585 0.158107407981823 160 25236383 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.00148876188948 0.160163240321888 no 586 0.158295285291729 183 688751 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.00086281242883 0.160317401491203 no 587 0.1584465686499 196 66535 A nucleotide analog. SGTC_585 0kpi-0023 191 µM 1.00041973575361 0.160426582665096 no 588 0.15855371148202 145 64601 SGTC_2768 sulfasalazine 50.2 µM 1.00034000478404 0.160446234806942 no 589 0.158572996713825 170 5384001 An antioxidant and salicylic acid derivative. SGTC_2927 9011802 47.9 µM 1.00025246914444 0.160467812460317 no 590 0.158594171501347 174 43912568 SGTC_1080 nisoldipine 24.4 µM 0.99975194999904 0.160591227517142 no 591 0.158715282213991 189 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3230 9131665 49.47 µM 0.999724474597765 0.16059800403405 no 592 0.158721932197172 161 15943720 SGTC_3303 9125618 40.5795 µM 0.995895471258339 0.161544213868632 no 593 0.159650467978453 177 22695467 SGTC_117 lucigenin 22.078 µM 0.995216048940961 0.161712489234231 no 594 0.159815598918419 185 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1547 harmine 94.2 µM 0.994696200121376 0.161841319481906 no 595 0.159942021568527 186 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1265 0819-1001 68.8 µM 0.993317061487138 0.16218342505201 no 596 0.160277732773038 191 3106768 SGTC_1363 1636-0063 10.4 µM 0.98939214049099 0.163159605733783 no 597 0.161235659208137 210 6072185 SGTC_2861 9024595 19.48 µM 0.987259206728968 0.163691693090411 no 598 0.1617577916668 148 16482810 SGTC_3264 9137442 49.47 µM 0.986858499316298 0.163791780184302 no 599 0.161856005826137 182 17015726 SGTC_2395 5646831 180.19 µM 0.986477247079236 0.163887044708604 no 600 0.161949487546799 189 6808628 SGTC_3234 9132280 49.47 µM 0.985097312940383 0.164232153098676 no 601 0.162288136568008 175 17612295 SGTC_3199 9111318 49.47 µM 0.983633694498268 0.164598704756683 no 602 0.16264782592984 170 8548020 SGTC_2564 betulinic acid 100 µM 0.983334898863974 0.164673600870694 no 603 0.162721319698914 174 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1923 st058458 19.1 µM 0.982058734761083 0.164993732668303 no 604 0.163035456640488 216 3534982 SGTC_2985 9022375 71.43 µM 0.98077813862455 0.165315381057284 no 605 0.163351080558044 193 4939335 SGTC_137 0438-0332 85.389 µM 0.980227920327783 0.165453704375151 no 606 0.163486812710099 213 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_23 0213-0011 39.996 µM 0.976818120130745 0.166312587598491 no 607 0.16432960182881 195 627608 SGTC_1616 st002734 56.1 µM 0.975397757511384 0.166671205977602 no 608 0.164681497798919 197 4026101 SGTC_1476 4112-3294 3.34 µM 0.974756954789036 0.166833161437687 no 609 0.164840416885747 192 704369 SGTC_2733 amorolfine 100 µM 0.973733879624508 0.167091942187523 no 610 0.165094345361532 214 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_146 3448-8650 53.125 µM 0.973381486564815 0.167181137801879 no 611 0.165181868341303 210 2891488 YIL048W NEO1 SGTC_1344 1488-0097 29.1 µM 0.97200099956697 0.167530853967211 no 612 0.165525025643229 206 747966 SGTC_734 2023-0417 80 µM 0.970742736147493 0.167850017692951 no 613 0.16583820235984 202 3935732 SGTC_2446 5162541 200 µM 0.967323972536152 0.168719176514108 no 614 0.166691051661904 188 1549321 SGTC_1257 0669-0121 16 µM 0.967319110197288 0.168720414732036 no 615 0.1666922666394 194 4307855 SGTC_754 3474-0146 171 µM 0.966948636912056 0.168814774705945 no 616 0.166784855500066 189 24762078 SGTC_1277 0873-0036 22 µM 0.966529844850862 0.168921482350592 no 617 0.166889560158403 188 5965735 SGTC_2950 9072895 21.46 µM 0.966413794054986 0.168951059600267 no 618 0.166918582199195 185 17332245 SGTC_977 1348-1378 135 µM 0.964183148943936 0.169520218695952 no 619 0.167477055601094 205 X977 SGTC_2091 4-phenylthiadiazole 200 µM 0.963104730523367 0.169795822626511 no 620 0.16774748402684 180 270010 SGTC_2487 5918373 44.05 µM 0.962714886158386 0.169895523122371 no 621 0.167845312083338 216 2876279 SGTC_1975 st070967 30.8 µM 0.962191518224745 0.170029430522788 no 622 0.167976704462284 226 261391 SGTC_405 ebelactone b 50 µM 0.961336583265043 0.170248317168108 no 623 0.168191479644167 159 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1961 st076550 68.7 µM 0.959623769122974 0.170687387146731 no 624 0.168622300935496 203 1579337 SGTC_1789 tunicamycin 25 nM 0.956045026216592 0.171607114216928 no 625 0.169524743394034 196 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1885 st057546 99.9 µM 0.955966299696655 0.171627382244338 no 626 0.169544630431318 184 702008 SGTC_3154 9100113 49.47 µM 0.955277360282537 0.171804813936153 no 627 0.169718726672785 192 25237525 SGTC_909 3448-9333 149 µM 0.952867637467576 0.172426342852789 no 628 0.170328569512315 176 3344074 SGTC_383 2324-0395 7.37 µM 0.952020923452981 0.17264507204645 no 629 0.17054318530159 180 3146421 SGTC_1603 st002045 67.8 µM 0.951441671593531 0.172794810372299 no 630 0.170690107415283 191 5887985 SGTC_958 1222-0007 33 µM 0.949745049967848 0.17323386821358 no 631 0.171120906517044 211 7312461 SGTC_2650 prasterone 100 µM 0.947720420012203 0.173758738058645 no 632 0.171635901301529 163 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2426 5582046 32.21 µM 0.946833757582185 0.173988916690934 no 633 0.171861748544995 184 2251934 SGTC_3237 9133362 49.47 µM 0.946692392581748 0.174025633125488 no 634 0.171897774026502 195 43845137 SGTC_2111 5486399 200 µM 0.945015497846426 0.174461545200311 no 635 0.172325481976064 195 689674 SGTC_2276 7947513 42.08 µM 0.943172382964891 0.174941465881543 no 636 0.172796368461296 176 2105100 SGTC_1458 k015-0034 6.33 µM 0.941023838907764 0.175501972343014 no 637 0.173346321411151 180 3598957 SGTC_277 nystatin 15.5 µM 0.940980102821475 0.175513393905232 no 638 0.173357527896354 194 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1574 spiramycin 23.7 µM 0.940964607960064 0.175517440459956 no 639 0.173361498251019 217 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1828 st055811 49 µM 0.940484734241226 0.175642790973057 no 640 0.173484488244201 190 5877589 SGTC_2476 5806916 10.51 µM 0.939879918977727 0.175800858949255 no 641 0.173639579411977 193 2870194 SGTC_2888 9058547 12.99 µM 0.939539062571703 0.175889981180836 no 642 0.173727023167669 161 16476514 SGTC_2109 5483026 200 µM 0.935478303309899 0.176953930294656 no 643 0.17477092983331 248 759335 SGTC_287 k060-0039 29.6 µM 0.93363178124253 0.177439075087829 no 644 0.175246932792228 201 5861974 SGTC_3176 9106582 49.47 µM 0.930503679627728 0.178262848858553 no 645 0.176055179928043 146 17018027 SGTC_2700 st077718 96.8 µM 0.927666195595293 0.179012170736026 no 646 0.176790374394692 191 904970 SGTC_2425 5628681 7.85 µM 0.924488703786838 0.179853630383715 no 647 0.177615965078536 200 5714958 SGTC_785 1270-0111 65.3 µM 0.923935902857119 0.180000275780783 no 648 0.177759844446846 202 6741994 SGTC_650 1328-0195 38 µM 0.923057017593483 0.180233578389195 no 649 0.177988746218008 205 2780821 SGTC_486 niguldipine 82 µM 0.918304699075429 0.181498380097101 no 650 0.179229683926066 209 1236 A calcium channel blocker. SGTC_1633 st005664 67.9 µM 0.917810864904563 0.181630129077611 no 651 0.1793589465519 195 2063822 SGTC_1689 st020265 53.493 µM 0.917387682913178 0.181743076514464 no 652 0.179469762375687 196 5758320 YPR016C TIF6 SGTC_3259 9138485 49.47 µM 0.914970897772594 0.182388959156873 no 653 0.180103454142089 180 17646153 SGTC_3059 1327-0034 3 µM 0.912309070495856 0.183101986290327 no 654 0.180803020405837 195 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1534 6-azauridine 81.6 µM 0.911865844820563 0.183220882387469 no 655 0.180919671661828 225 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_256 clotrimazole 625 nM 0.910472235288277 0.183595034303428 no 656 0.181286758849856 194 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1865 st057639 52.2 µM 0.90834408019316 0.184167312673452 no 657 0.181848230097379 221 688818 SGTC_2140 5586273 200 µM 0.907599949971698 0.1843676770997 no 658 0.182044810382005 184 854421 SGTC_151 3013-0144 2.285 µM 0.902861077876482 0.185646845012197 no 659 0.183299815071181 231 906558 YHR107C CDC12 SGTC_2998 9066762 71.4286 µM 0.902853164912496 0.185648985560216 no 660 0.183301915178403 192 4945196 SGTC_3166 9102297 49.47 µM 0.902191941077318 0.185827908334488 no 661 0.183477457541289 207 25237072 SGTC_147 4466-0538 29.23 µM 0.901709309819941 0.185958572642277 no 662 0.183605653102431 221 6742687 YHR072W ERG7 SGTC_1196 1588-0294 184 µM 0.900867204172354 0.186186694979058 no 663 0.183829465161735 203 6144269 SGTC_1388 3346-4487 254 µM 0.900365793255367 0.186322607105767 no 664 0.183962809178962 217 3345614 SGTC_1068 loratadine 26.9 µM 0.899404585940891 0.186583323163348 no 665 0.184218598693082 204 3957 A H1 histamine antagonist. SGTC_581 0958-0271 211 µM 0.899301531711585 0.186611288799696 no 666 0.184246035868264 211 4591145 SGTC_1678 st019265 80.2 µM 0.897187558301495 0.187185526412875 no 667 0.184809421520008 197 5367020 SGTC_1004 4084-0029 199 µM 0.896686034645141 0.187321920005105 no 668 0.184943237347625 200 716894 YLR208W SEC13 SGTC_2670 beta-carotene 100 µM 0.895921633497402 0.187529923506433 no 669 0.18514730955611 170 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2736 butenafine 14.65 µM 0.893741789018558 0.188123870999752 no 670 0.18573003045835 202 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3021 9087658 49.47 µM 0.892924290646361 0.188346915773458 no 671 0.185948858979075 188 25237042 SGTC_1738 st035555 74 µM 0.892082286699742 0.188576817064997 no 672 0.186174414220515 208 5331140 SGTC_2068 5226020 147 µM 0.890780339000433 0.188932642125839 no 673 0.186523512404458 210 1810509 SGTC_2474 5321570 43.32 µM 0.889294285547776 0.189339288828382 no 674 0.186922470917647 210 2841384 SGTC_2213 7173844 200 µM 0.887817612320861 0.189743901931444 no 675 0.187319433739052 216 892728 SGTC_2138 5575593 77.673 µM 0.887738151025666 0.189765689642811 no 676 0.187340809481174 203 762213 SGTC_253 dyclonine 31.25 µM 0.887648637142185 0.189790235543816 no 677 0.187364891258374 194 3180 An oral anasthetic. SGTC_235 0330-0087 5 mM 0.88554771034699 0.190366898247399 no 678 0.187930649653878 205 46494818 YHR062C RPP1 SGTC_2192 5915882 198.485 µM 0.883593680181268 0.19090420552401 no 679 0.18845779591488 201 2876149 SGTC_3044 9093193 49.47 µM 0.88346940619515 0.190938409062269 no 680 0.188491352602159 223 25236277 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.882403421760891 0.191231950994281 no 681 0.188779342989821 241 5357218 A potent inhibitor of glutathione S-transferases. SGTC_187 1488-2104 32.728 µM 0.880956439470073 0.191630851303867 no 682 0.189170698815149 211 2852859 SGTC_2595 hexamethylquercetagetin 100 µM 0.880874096309216 0.19165356676799 no 683 0.189192984644372 231 386331 SGTC_127 0180-0333 59.125 µM 0.878098984108563 0.192420082707311 no 684 0.1899450021218 177 771601 SGTC_393 acivicin 6.25 µM 0.878005571428414 0.192445916865443 no 685 0.189970347608208 215 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3114 9122766 49.47 µM 0.877823886302828 0.192496169674314 no 686 0.190019649844478 180 17176985 SGTC_217 ketoconazole 989 nM 0.877034932082306 0.192714481818899 no 687 0.190233832369848 209 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_130 0136-0219 337.655 µM 0.87519507585062 0.193224177350534 no 688 0.190733886021777 251 234244 SGTC_833 3852-0053 558 µM 0.873309417309352 0.193747414397408 no 689 0.191247224451225 222 3123681 SGTC_458 nppb 133 µM 0.872022589956805 0.194104981730336 no 690 0.191598026999547 200 4549 A chloride channel blocker. SGTC_2128 5255449 168.493 µM 0.871504901515875 0.194248943775776 no 691 0.191739265371735 203 736008 SGTC_3065 9113888 49.47 µM 0.871231714371545 0.194324939571818 no 692 0.191813823358815 213 16648368 SGTC_3281 9140613 49.47 µM 0.869975218609186 0.194674707360462 no 693 0.19215697355372 189 16013766 SGTC_119 0121-0043 24.815 µM 0.868153571648255 0.19518247464332 no 694 0.19265513353151 234 1092378 SGTC_1449 4112-4002 201 µM 0.867274818712722 0.195427706436464 no 695 0.192895725225358 201 2059539 SGTC_2089 5281248 129.67 µM 0.866050198339728 0.195769770723376 no 696 0.193231317070431 199 2737878 SGTC_1240 0356-0016 42.1 µM 0.865299482019797 0.195979642393865 no 697 0.193437217528842 206 4305613 SGTC_314 1671-0008 2.74 µM 0.863957145524634 0.196355248579353 no 698 0.19380571631404 231 3913060 SGTC_3190 9110366 49.47 µM 0.862966093028147 0.196632839962206 no 699 0.194078054868702 194 17123768 SGTC_1127 asiatic acid 681.4 nM 0.862364252492634 0.196801529985728 no 700 0.194243552748167 226 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2828 7998861 71.43 µM 0.86168917118588 0.196990852926948 no 701 0.194429293069065 172 2988188 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.861106819180368 0.197154258967279 no 702 0.194589606893268 211 17037758 SGTC_3283 9109332 35.8195 µM 0.858580474736274 0.197864091995599 no 703 0.19528600709807 193 17027281 SGTC_1315 1237-0019 3.69 µM 0.858023577786375 0.198020772093241 no 704 0.195439722137176 204 825140 SGTC_2551 apiole 73.87 µM 0.856935321489185 0.198327163603119 no 705 0.195740315355742 188 10659 A possible DNA adduct former. SGTC_1733 st037357 54.9 µM 0.855659223728354 0.1986868048675 no 706 0.196093150528503 228 1272339 YGL099W LSG1 SGTC_1670 st016595 4.04 µM 0.85507728802666 0.198850941660591 no 707 0.196254181062614 251 597879 SGTC_2008 4012253 172 µM 0.853446054556695 0.199311471665396 no 708 0.196705995551596 201 603940 SGTC_2594 a-mangostin 100 µM 0.853274267812886 0.199360007868548 no 709 0.196753613203465 229 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2055 5235184 200 µM 0.85152121739502 0.199855717164324 no 710 0.197239941119826 232 2836034 SGTC_3216 9129716 49.47 µM 0.849157514236543 0.20052527285864 no 711 0.19789682528023 207 8056934 SGTC_1620 st003704 16.5 µM 0.848097885070801 0.200825866087209 no 712 0.198191729684249 220 2834414 SGTC_2363 9053361 176 µM 0.847714494115464 0.200934692160304 no 713 0.198298496189016 231 6469797 YMR079W SEC14 SGTC_1843 st055809 45.5 µM 0.846583171450009 0.201256025904352 no 714 0.198613748595032 219 16413835 SGTC_2829 7992743 58.44 µM 0.845690332932866 0.201509839499774 no 715 0.198862758702607 209 16462845 SGTC_1726 st035556 14.5795 µM 0.84542695497432 0.201584748455977 no 716 0.198936249990055 184 5919439 SGTC_1438 4092-1045 4 µM 0.844897406875235 0.201735410992097 no 717 0.19908406120828 237 1351342 SGTC_801 0866-0028 10.1 µM 0.844404939186716 0.201875584225528 no 718 0.199221581641767 231 6849771 SGTC_1850 st056238 17 µM 0.839820422306225 0.203183291284123 no 719 0.200504540552424 237 5393177 SGTC_2814 7977482 42.97 µM 0.839689325985008 0.203220759968145 no 720 0.200541300161823 225 6456762 SGTC_2328 6201408 200 µM 0.838806351089954 0.203473230736599 no 721 0.20078899308321 244 2890418 SGTC_717 1532-0246 73.2 µM 0.834673921385856 0.204657309271827 no 722 0.201950664408348 210 9561992 SGTC_157 1348-1695 65.819 µM 0.834189193717193 0.204796467986537 no 723 0.202087189808229 239 5380510 SGTC_413 propylparaben 100 µM 0.832280111275207 0.205345086580314 no 724 0.202625427051754 217 7175 A pharmaceutical preservative. SGTC_1372 2752-0194 270 µM 0.831035457167032 0.205703236088409 no 725 0.202976799602038 218 823334 SGTC_2843 9000894 45.46 µM 0.828494364210235 0.206435586232254 no 726 0.203695292660914 163 2242070 SGTC_1163 k060-0048 49.9 µM 0.827270227470051 0.206788936537078 no 727 0.204041957375323 218 6809982 SGTC_2532 xanthone 78.9 µM 0.826329079524992 0.207060844682602 no 728 0.204308721001196 204 7020 An insecticide. SGTC_1815 st051655 58.2 µM 0.824679371409513 0.2075379738045 no 729 0.204776823117374 233 5984156 SGTC_2493 resveratrol 26.09 µM 0.824578928024695 0.20756704504254 no 730 0.204805344357663 202 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_711 k292-0785 179 µM 0.823724346865159 0.207814483014086 no 731 0.205048101122262 234 4146315 SGTC_249 wiskostatin 11.211 µM 0.823469198695269 0.207888393131616 no 732 0.205120612978199 214 2775510 A n-wasp and actin depolymerizer. SGTC_2763 lisinopril 49.32 µM 0.823350956887028 0.207922650123318 no 733 0.205154221885784 239 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1325 1431-0015 227 µM 0.822329498499697 0.208218725574118 no 734 0.205444696187231 201 1103340 SGTC_1891 st059073 26.2 µM 0.820893371028239 0.208635415665635 no 735 0.205853503643487 240 688754 SGTC_604 1000-0114 314 µM 0.820327561312959 0.208799719339542 no 736 0.206014699241717 236 1572745 SGTC_3179 9107801 49.47 µM 0.819380276066924 0.20907496908916 no 737 0.206284742318132 210 4818259 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.818878313869199 0.209220909264229 no 738 0.206427921930967 244 2346 DNA damaging agent; causes G2/M arrest. SGTC_920 mycophenolic acid 780.421 nM 0.816402534863349 0.209941592504317 no 739 0.207134973656826 222 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1008 4106-0037 6 µM 0.815922783207456 0.210081413658614 no 740 0.207272150278807 253 2905394 SGTC_907 3448-6986 75.5 µM 0.815718249417941 0.21014104061013 no 741 0.20733064948007 233 590582 SGTC_1307 1187-1599 12.2 µM 0.815542713275338 0.210192221914933 no 742 0.207380862777857 246 1538471 SGTC_3307 9126885 69.2785 µM 0.814040641658511 0.210630482208429 no 743 0.207810834398725 206 24824909 SGTC_356 1634-0012 32.5 µM 0.814005512175334 0.210640738369941 no 744 0.207820896594778 250 735457 SGTC_2460 5552655 174.22 µM 0.813087071493112 0.210908983929565 no 745 0.208084069168769 240 5401989 SGTC_2215 7188065 200 µM 0.812748765462222 0.211007842172287 no 746 0.208181057880397 237 940217 SGTC_2207 7258803 200 µM 0.809424741624722 0.211980616954353 no 747 0.209135437747437 239 3666799 SGTC_954 1189-0853 2.85 µM 0.809398342266818 0.211988353203826 no 748 0.20914302771739 240 2828194 SGTC_2978 9011784 42.97 µM 0.809139592552623 0.212064187740808 no 749 0.209217428359703 210 2994934 SGTC_46 0329-0187a 2.197 µM 0.808268842427022 0.212319504251763 no 750 0.209467917421393 236 46494817 SGTC_14 0354-0009 295 µM 0.804739118612412 0.21335630863287 no 751 0.210485120293837 258 1713507 SGTC_653 0203-0016 55.2 µM 0.804617040604501 0.213392219977217 no 752 0.210520352771221 236 295302 SGTC_1776 st049249 45.9 µM 0.803510447188079 0.213717904143668 no 753 0.210839880410409 245 1822314 SGTC_252 miconazole 1.30953 nM 0.802145292078828 0.214120084863233 no 754 0.211234459057519 228 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1259 0671-0132 43 µM 0.801660498216829 0.214263013177582 no 755 0.211374685857327 227 X1259 SGTC_2478 5763493 32.33 µM 0.801426232377639 0.214332099987864 no 756 0.211442466870782 236 1365576 YLR208W SEC13 SGTC_1741 st038134 10.228 µM 0.799759019167776 0.21482414815722 no 757 0.211925215423785 216 1272587 SGTC_280 3448-3607 3.04 µM 0.798925255698615 0.215070464487321 no 758 0.212166876753503 205 626179 SGTC_3343 9148379 18.9835 µM 0.79686289757541 0.215680444954854 no 759 0.212765330506638 236 1955036 SGTC_871 0574-0004 149 µM 0.796573676633206 0.215766067504724 no 760 0.212849335173312 242 9551173 SGTC_1293 1000-1278 195 µM 0.796012909281275 0.215932136262079 no 761 0.213012266055442 254 678847 SGTC_2899 9053889 58.44 µM 0.790664353231042 0.217519805056983 no 762 0.214569941422313 227 6470052 SGTC_612 0302-0167 22.4 µM 0.789384269062129 0.217900782942404 no 763 0.214943723649191 257 235821 SGTC_2640 pentamidine 10.38 µM 0.788678809322291 0.218110905808937 no 764 0.215149878126491 245 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2124 5246320 200 µM 0.78362796220066 0.219618720134819 no 765 0.21662922170875 251 579342 SGTC_3090 9117696 49.47 µM 0.781518636626745 0.220250178466222 no 766 0.217248759965021 227 7923821 SGTC_3269 9137823 49.47 µM 0.781461606044777 0.220267265870366 no 767 0.217265524836462 202 17682936 SGTC_2020 4017018 200 µM 0.780321672554012 0.220608970168118 no 768 0.217600779612332 246 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_893 0958-0369 48.9 µM 0.779995930164042 0.220706669848314 no 769 0.217696635360827 250 6819948 SGTC_2356 9061756 188.97 µM 0.777596406692513 0.221427120406824 no 770 0.218403490026193 228 20104043 SGTC_2657 nystatin 74.44 µM 0.777586845214322 0.221429993902346 no 771 0.21840630930028 239 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2738 aclarubicin 5.55 µM 0.776700975605217 0.221696315337127 no 772 0.218667605570065 208 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2587 piperic acid 92.2 µM 0.776414430730091 0.22178249927491 no 773 0.218752163400858 236 5370536 SGTC_2384 9036245 200 µM 0.7760815370979 0.221882647530645 no 774 0.218850422122313 214 6462766 SGTC_946 3434-1334 87.4 µM 0.774856476925818 0.22225141893202 no 775 0.219212236240143 236 4047976 SGTC_200 k038-0079 37.545 µM 0.773595324820732 0.22263141989989 no 776 0.219585068837681 266 3436683 SGTC_2489 cantharidin 73.42 µM 0.773169493468898 0.22275981182839 no 777 0.219711038949187 242 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3180 9109287 49.47 µM 0.773074434902653 0.222788478589015 no 778 0.219739164990079 244 18891271 SGTC_866 0495-0101 262 µM 0.771240334625931 0.223341998643322 no 779 0.220282245308259 235 635694 SGTC_2524 avocatin b 10.57 µM 0.771059450896467 0.223396630591683 no 780 0.220335846957332 228 6710748 SGTC_2108 5365811 200 µM 0.77068444652717 0.223509916624785 no 781 0.22044699659284 239 780283 SGTC_839 0122-0028 230 µM 0.769919498451672 0.223741103038421 no 782 0.220673823419644 270 759448 SGTC_3157 9099274 49.47 µM 0.769596967299355 0.223838620736704 no 783 0.220769502274762 237 17217662 SGTC_1139 k015-0024 46.9 µM 0.769564998655495 0.223848287811953 no 784 0.220778987065731 248 2766652 SGTC_1514 1189-1591 158 µM 0.769560769778245 0.223849566610104 no 785 0.220780241750653 261 767698 YMR146C TIF34 SGTC_2179 6298986 200 µM 0.769408360944228 0.223895657296359 no 786 0.220825463349613 235 738374 SGTC_2357 9067248 200 µM 0.76906567173919 0.223999311275389 no 787 0.220927162871291 247 9150235 SGTC_1705 st027868 56.3335 µM 0.768906695847717 0.224047406328854 no 788 0.220974351085182 241 292948 SGTC_1610 st001799 48.1 µM 0.768656257495578 0.224123183462979 no 789 0.22104869945726 240 621897 SGTC_1017 4239-0030 168 µM 0.767463184408529 0.224484380912417 no 790 0.221403087067558 242 1149593 SGTC_2145 5634607 200 µM 0.767246463264075 0.224550027685614 no 791 0.221467496251563 244 308662 SGTC_2155 5570423 76 µM 0.765476803194056 0.225086480964601 no 792 0.221993837146888 248 797402 SGTC_88 0180-0332 8.668 µM 0.763800665327155 0.225595252928459 no 793 0.222493020145075 256 3101745 SGTC_927 2425-1185 123 µM 0.762876155229953 0.225876155342717 no 794 0.22276862899778 257 730375 SGTC_1267 0828-0272 9.49 µM 0.762450205361094 0.22600564214017 no 795 0.222895675802664 245 745334 SGTC_1941 st076221 61.8 µM 0.758371144191546 0.227247780967923 no 796 0.224114413725319 241 2828568 SGTC_1653 st012112 65 µM 0.757897105259269 0.227392382454487 no 797 0.224256291683864 249 720429 SGTC_1979 st071809 45.3 µM 0.757852222063208 0.227406076371967 no 798 0.224269727687415 268 4976333 SGTC_950 1165-0508 94.1 µM 0.757569058121027 0.227492480743561 no 799 0.22435450473062 254 6148369 SGTC_3032 9089427 49.47 µM 0.756036831979125 0.227960343331156 no 800 0.224813556516883 232 17173707 SGTC_2456 5770359 74.46 µM 0.754840623620517 0.228325979403194 no 801 0.225172307941344 275 3118787 SGTC_716 1683-5115 658 µM 0.75456488510926 0.228410309055079 no 802 0.225255049858809 266 723597 SGTC_3116 9124943 49.47 µM 0.753030401408704 0.228879922788657 no 803 0.22571582272935 237 41905195 YPL160W CDC60 SGTC_1023 4482-3888 16 µM 0.752446207662446 0.229058851894647 no 804 0.22589138374819 260 3303168 SGTC_3153 9100258 49.47 µM 0.751974094981173 0.229203509694625 no 805 0.226033318732459 249 25236848 SGTC_747 3448-8087 38.7 µM 0.749351815659377 0.230007921675293 no 806 0.22682259238407 258 5168703 SGTC_2346 9031566 143.75 µM 0.747718073220704 0.230509887219504 no 807 0.22731511371593 245 4771086 SGTC_2385 9074692 200 µM 0.747225215204623 0.230661437425279 no 808 0.227463812944497 247 17046906 SGTC_376 3970-0862 59.1 µM 0.745751250651544 0.23111500267896 no 809 0.227908846689212 270 3135186 SGTC_1943 st076331 65.2 µM 0.741855937233963 0.232316052697332 no 810 0.22908731250201 256 24208415 SGTC_339 3091-4833 71.4 µM 0.741538721759161 0.232414013067907 no 811 0.2291834313355 258 3240077 SGTC_206 4546-0025 72.014 µM 0.741515766978508 0.232421102701724 no 812 0.229190387695589 275 6620745 YIL048W NEO1 SGTC_762 1165-0429 115 µM 0.737848324935662 0.233555343689338 no 813 0.2303033117962 251 5967793 SGTC_3351 9150312 21.596 µM 0.737682502468407 0.233606700542342 no 814 0.230353703689007 265 4904905 SGTC_1062 mesoridazine 14.2 µM 0.736844140044991 0.233866445486018 no 815 0.230608568523587 246 4078 A neuroleptic. SGTC_1258 0671-0043 57.1 µM 0.736270572722671 0.234044242663709 no 816 0.230783025543854 265 4298767 SGTC_2272 7805186 180 µM 0.734380665429026 0.23463061470811 no 817 0.231358383610321 279 2956062 YPR165W RHO1 SGTC_2876 9059903 25.97 µM 0.733674496597565 0.234849922487839 no 818 0.231573572792711 244 6916095 SGTC_669 0108-0021 26.2 µM 0.733096019432121 0.235029658732922 no 819 0.231749933887094 296 17201 SGTC_2499 avocadenofuran 51.48 µM 0.732918201277538 0.235084923141748 no 820 0.231804160574721 258 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2150 5556613 200 µM 0.732629040848067 0.235174807131815 no 821 0.231892356832093 279 743190 SGTC_1371 2421-0008 32.7 µM 0.73242734827783 0.235237513434593 no 822 0.231953885751384 255 2827552 SGTC_1940 st075990 51.1 µM 0.73177789609174 0.235439491095599 no 823 0.232152071269231 268 1084979 SGTC_442 cape 100 µM 0.731076016208951 0.235657881173725 no 824 0.232366361441857 246 5281787 SGTC_390 dec-rvkr-cmk 16.7 µM 0.730649033114436 0.235790791696817 no 825 0.232496776989063 249 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3004 9076122 71.4286 µM 0.730271822209114 0.235908243599492 no 826 0.232612024226041 269 44782551 SGTC_1308 1187-1617 41.4 µM 0.730226740525355 0.235922282809634 no 827 0.232625799916794 264 2882570 SGTC_1647 st011722 22.4 µM 0.730204615961002 0.235929172947188 no 828 0.232632560725398 250 2854783 SGTC_299 1273-0059 1.44 µM 0.728929907416921 0.236326335992686 no 829 0.233022269636654 252 2848077 SGTC_1468 k284-1086 134 µM 0.72806835243651 0.236594980444342 no 830 0.233285872808263 256 15996457 SGTC_783 0848-0141 92.7 µM 0.726868345252144 0.236969438683189 no 831 0.233653305136922 273 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1231 0242-0792 125 µM 0.725657404714304 0.23734763862702 no 832 0.234024410194572 261 3707635 SGTC_2799 7812892 81.82 µM 0.725419938592117 0.237421842701477 no 833 0.234097222374909 269 20205235 SGTC_2073 5212005 126 µM 0.725217722487496 0.237485041791917 no 834 0.234159236036774 281 691789 SGTC_1937 st074714 47.2 µM 0.724474152257801 0.237717510990267 no 835 0.234387345099316 236 17250970 SGTC_1613 st002381 52.1 µM 0.724459920861976 0.237721961499565 no 836 0.234391712140569 265 551167 SGTC_2286 7945697 125 µM 0.723772591979135 0.237936960636722 no 837 0.234602679237352 258 1245733 SGTC_822 1487-0950 154 µM 0.723309985199931 0.238081725831399 no 838 0.234744729771512 240 1958375 SGTC_2041 5107442 45.335 µM 0.720989666956474 0.238808559065487 no 839 0.235457936131123 265 793005 SGTC_1936 st074407 74.3 µM 0.717858954960052 0.239791166538099 no 840 0.236422128987167 263 809813 SGTC_2061 5245884 80.95 µM 0.716792833277578 0.240126283029043 no 841 0.236750967231563 274 573863 SGTC_2246 7293507 91.5585 µM 0.716452132696594 0.240233430031717 no 842 0.236856107106176 265 887656 SGTC_652 0437-0092 114 µM 0.716383161600324 0.240255123937928 no 843 0.236877394644926 248 3091274 SGTC_3340 9146634 11.102 µM 0.714018363127403 0.24099958403554 no 844 0.237607912280533 238 4907387 SGTC_1516 st013856 110 µM 0.713840419693101 0.241055652954798 no 845 0.237662931336269 250 5281404 A mutagen and neurotoxin. SGTC_3086 9117350 49.47 µM 0.712309174209342 0.241538432317952 no 846 0.23813667212394 242 2679265 SGTC_1289 0976-0073 69.1 µM 0.712118161752956 0.241598692571907 no 847 0.238195804343981 264 3391136 SGTC_1980 st071811 45.7 µM 0.711958501600091 0.24164906812193 no 848 0.238245236922204 264 4974850 SGTC_3100 9120536 49.47 µM 0.71143211058618 0.241815194009641 no 849 0.238408253298816 264 16421196 SGTC_2902 5787006 60.46 µM 0.710746922917707 0.242031527984768 no 850 0.238620538376203 267 591003 SGTC_550 4123-0385 25.7 µM 0.710336183457075 0.242161260859499 no 851 0.238747843392698 260 5731123 SGTC_2075 5212009 200 µM 0.709737697765371 0.242350361221169 no 852 0.238933405168289 274 780898 SGTC_1563 conessine 56.1 µM 0.709009320024057 0.242580610793328 no 853 0.239159346609794 264 441082 An anti-amoebic, histamine inhibitor. SGTC_1248 0469-0687 58.6 µM 0.708765946097223 0.242657570816877 no 854 0.239234866772898 256 4017482 SGTC_600 1495-0418 41.6 µM 0.708686961702351 0.24268255020714 no 855 0.239259378831226 283 5377768 SGTC_721 1187-1332 279 µM 0.706916560208466 0.243242817712448 no 856 0.239809166071636 280 25730 SGTC_2219 9098279 200 µM 0.706684153317796 0.243316417899557 no 857 0.239881389737056 239 902349 SGTC_1439 4092-1168 46 µM 0.706345658946254 0.243423636115391 no 858 0.239986602779758 284 2886240 SGTC_1470 k295-0292 231 µM 0.705362988402485 0.243735041937162 no 859 0.240292185402709 280 5045612 SGTC_306 1672-3436 11.6 µM 0.704888478381719 0.243885489929284 no 860 0.240439820408189 286 6797378 SGTC_1766 st045414 44.774 µM 0.704540673770507 0.24399579656476 no 861 0.240548064740428 283 253960 SGTC_1500 4488-1866 171 µM 0.703746517923935 0.244247764866038 no 862 0.240795322678161 290 2900003 SGTC_1976 st070609 63.5 µM 0.701931705268547 0.244824091430278 no 863 0.241360877655692 262 682556 SGTC_1168 k815-0004 80.5 µM 0.701777522641424 0.244873088622879 no 864 0.241408959243161 281 642433 SGTC_1298 1079-1278 263 µM 0.701247581544855 0.245041537104073 no 865 0.241574260133713 269 2840950 SGTC_883 0850-0245 24.6 µM 0.699389769479631 0.24563255814163 no 866 0.242154239794417 264 6823229 YPR165W RHO1 SGTC_599 1935-0052 86.5 µM 0.698571998121244 0.245892956129469 no 867 0.242409774209902 253 9557311 SGTC_2066 5222451 176 µM 0.696949811093407 0.246409937453815 no 868 0.242917101737212 266 2281147 SGTC_1755 st041960 45.185 µM 0.696101092343984 0.246680650985138 no 869 0.243182761248891 279 2257073 SGTC_1287 0971-0001 34.6 µM 0.695871407597475 0.246753940284051 no 870 0.24325468242456 264 4665869 SGTC_319 1348-1596 45.5 µM 0.694539604215378 0.247179130435061 no 871 0.24367193649173 271 5380505 SGTC_1987 st072290 61.9 µM 0.690256433272789 0.248549223291199 no 872 0.245016470069252 274 54697379 SGTC_1567 st069303 68.4 µM 0.690097201142879 0.248600236061568 no 873 0.24506653158283 272 5581319 SGTC_1935 st074532 41.6 µM 0.687859389847098 0.249317747257101 no 874 0.245770666075355 275 2829742 SGTC_674 0498-0004 451 µM 0.687523353249826 0.249425585931068 no 875 0.245876494783649 270 4231473 SGTC_3262 9137218 49.47 µM 0.687478543822372 0.249439967753421 no 876 0.24589060855823 237 17650664 SGTC_1203 3992-3522 103 µM 0.687018101522047 0.2495877746687 no 877 0.246035660788104 287 5322312 SGTC_2515 chrysin 20.77 µM 0.685877497436469 0.249954121106215 no 878 0.246395180658555 260 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2986 9022445 71.43 µM 0.685862641712612 0.249958894443488 no 879 0.246399865058496 279 6459286 SGTC_26 0302-0163 425.158 µM 0.685608790433325 0.250040467636257 no 880 0.246479918410315 303 3100915 SGTC_2199 6590217 200 µM 0.685194801545031 0.250173530135198 no 881 0.246610501899443 244 703109 SGTC_2163 5671233 125 µM 0.682982327184174 0.250885290189285 no 882 0.24730900496317 264 701023 SGTC_2014 4013930 200 µM 0.682885919245724 0.250916329282976 no 883 0.247339466064565 275 64556 SGTC_398 bronopol 33.3 µM 0.682660152610008 0.250989024109894 no 884 0.247410807252878 265 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2751 anetholtrithion 17.25 µM 0.68250189735415 0.251039987522778 no 885 0.247460821720261 274 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_936 3005-4620 401 µM 0.682040233104114 0.251188689917996 no 886 0.247606755426858 279 777207 SGTC_1071 trifluoperazine 6.31 µM 0.681864151168608 0.251245418308976 no 887 0.247662427659108 294 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_47 0149-0135 24.25 µM 0.68046186780778 0.251697434224488 no 888 0.248106029346427 270 5239155 SGTC_2520 obtusaquinone 4.71 µM 0.679263096055738 0.252084189877958 no 889 0.248485587456964 278 5967872 SGTC_3353 9151644 39.2805 µM 0.679095477753624 0.252138292972803 no 890 0.248538683828727 266 4909158 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.678041354893452 0.252478678416463 no 891 0.248872736333966 276 803109 SGTC_577 r071-0003 38.6 µM 0.677183333049196 0.25275591979712 no 892 0.24914482058493 299 4568517 YMR134W ERG29 SGTC_101 0490-5701 117.494 µM 0.676740423700195 0.252899094008105 no 893 0.249285331881656 266 4661669 SGTC_1060 3448-7350 82 µM 0.67485773971994 0.253508163645587 no 894 0.249883076064126 280 570178 SGTC_712 r015-0009 80.6 µM 0.673678867403444 0.253889934243652 no 895 0.250257750005906 280 6813872 YLR060W FRS1 SGTC_2819 7996655 46.38 µM 0.67347372123705 0.253956400387262 no 896 0.250322980801701 261 6456960 SGTC_2937 9044753 11.33 µM 0.673447387692776 0.253964932960953 no 897 0.25033135479177 270 6465530 YGL099W LSG1 SGTC_797 k781-0471 270 µM 0.672655936637978 0.254221448478237 no 898 0.250583103203188 276 23738129 SGTC_3248 9135562 49.47 µM 0.671292932928997 0.254663526953311 no 899 0.251016967912897 282 17650701 SGTC_3013 9080133 71.4286 µM 0.671252837110809 0.254676537778566 no 900 0.251029737034325 286 17050193 SGTC_2116 5511452 16.8835 µM 0.670462673532297 0.254933011591311 no 901 0.251281446717874 292 870744 SGTC_1422 4031-0024 15.5 µM 0.670089829150036 0.255054077526821 no 902 0.25140026407071 298 782427 SGTC_370 0180-0345 38.7 µM 0.66828608363566 0.255640194400288 no 903 0.251975497403535 265 3989527 SGTC_1057 3448-5381 134 µM 0.667659610880787 0.255843927622769 no 904 0.252175448512394 264 5497911 SGTC_593 1203-0218 61.7 µM 0.662383836808294 0.257563001407343 no 905 0.253862629844264 290 3666956 SGTC_844 0330-0132 15.3 µM 0.658891515303455 0.258704240748595 no 906 0.254982717351373 285 2828079 SGTC_1562 morin hydrate 59.1 µM 0.65880387533001 0.258732913834799 no 907 0.25501085922229 286 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_766 1391-0721 126 µM 0.658265935395277 0.258908947155791 no 908 0.255183631473056 299 1020919 YIL115C NUP159 SGTC_1492 4158-0558 28.5 µM 0.658046435871383 0.25898079310009 no 909 0.255254146564277 256 3967268 SGTC_1398 3558-0053 112 µM 0.656508171129273 0.259484582630002 no 910 0.25574860591911 266 4532369 SGTC_1752 st044819 83.042 µM 0.656351970290909 0.259535767491602 no 911 0.255798843021843 278 441209 YML126C ERG13 SGTC_340 k038-0059 454 µM 0.647794242386244 0.262347963103271 no 912 0.258559019911249 294 23733424 SGTC_1016 4226-1401 38 µM 0.647779677113318 0.262352762735314 no 913 0.258563730852 291 2901613 SGTC_1886 st057356 49.9 µM 0.646481288205074 0.262780795874605 no 914 0.258983855718678 278 24207747 SGTC_2647 atorvastatin 60.16 µM 0.6434059764183 0.263796040940388 no 915 0.259980353249089 275 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3075 9116269 49.47 µM 0.642363878032154 0.264140519450353 no 916 0.260318473824469 301 17015205 YNL244C SUI1 SGTC_645 0845-0943 5.41 µM 0.640926493052712 0.264616040556884 no 917 0.260785221078509 272 1885106 SGTC_1959 st077091 55.8 µM 0.640158553559292 0.264870271541764 no 918 0.261034762529008 299 821356 YKL052C ASK1 SGTC_988 1497-1057 103 µM 0.639875036377292 0.264964162977901 no 919 0.26112692227529 300 3533044 SGTC_2137 5261020 140 µM 0.639125783837958 0.265212371811476 no 920 0.261370553854043 288 763655 SGTC_2080 5212524 12.4 µM 0.639025125474022 0.265245726431384 no 921 0.26140329344231 305 260183 SGTC_3328 9140624 29.0385 µM 0.636689365067643 0.2660203124235 no 922 0.262163601106157 288 4904392 SGTC_2172 5754775 163.918 µM 0.63596564163923 0.266260546228483 no 923 0.262399408282696 280 2263357 SGTC_3082 9117008 49.47 µM 0.633723939719515 0.267005356196909 no 924 0.263130499348941 300 41448529 SGTC_2661 dactinomycin 12.96 µM 0.631984996769056 0.267583847287702 no 925 0.263698340496685 285 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_727 3032-0951 202 µM 0.63040676520221 0.26810942121019 no 926 0.264214242856269 300 3652836 SGTC_415 dibenzyl ketone 100 µM 0.629952893463575 0.26826066319944 no 927 0.264362702445835 311 7593 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.627115775490709 0.269207037123718 no 928 0.265291673496692 280 16623 A steroid. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.626369309167702 0.269456312971214 no 929 0.265536367594071 305 23847180 SGTC_1978 st071761 42 µM 0.625471698815657 0.269756215167046 no 930 0.265830758729406 287 5147680 SGTC_2435 5706476 10.6 µM 0.623032928151047 0.270571880317562 no 931 0.266631441803085 276 5725375 SGTC_1840 st055363 71 µM 0.622491699038534 0.270753065360331 no 932 0.266809300197569 300 676033 SGTC_1629 st005085 44.9 µM 0.622346226816295 0.270801774823952 no 933 0.26685711541473 297 24207091 SGTC_2568 diosmetin 100 µM 0.622104704493712 0.270882655061398 no 934 0.26693651086793 310 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1841 st054148 70 µM 0.622013756357106 0.27091311461216 no 935 0.266966411273369 314 675442 SGTC_2049 5262831 67.185 µM 0.620913615724089 0.271281699367623 no 936 0.267328231030056 303 763417 SGTC_1313 1220-0047 237 µM 0.620769645445224 0.271329952825887 no 937 0.267375598996301 294 3528706 SGTC_3069 9117009 49.47 µM 0.619845847620118 0.271639677082317 no 938 0.26767964038477 277 41904981 SGTC_1792 st045773 43.6 µM 0.619604032337601 0.271720780221347 no 939 0.267759255670324 260 2919270 SGTC_2993 9054257 71.4286 µM 0.619486391998659 0.271760240318382 no 940 0.26779799189988 304 6470217 YGL055W OLE1 SGTC_2381 9035592 200 µM 0.618374558951435 0.272133323254587 no 941 0.268164232060378 292 4749657 SGTC_1504 k297-0033 30 µM 0.618075397602344 0.272233752278456 no 942 0.268262819459897 254 4388117 SGTC_2740 felodipine 17.08 µM 0.617123286512591 0.27255350028902 no 943 0.268576705091399 270 3333 L-type calcium channel blocker SGTC_2854 9024559 71.43 µM 0.616136858009973 0.272884969667087 no 944 0.268902098834312 309 3163529 SGTC_2669 eugenol 100 µM 0.613892588275727 0.273639855269348 no 945 0.269643154128327 283 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2175 5807670 165.306 µM 0.613421569902063 0.273798418724421 no 946 0.269798813648475 272 241186 SGTC_1718 roemerine 11.9335 µM 0.613320650650101 0.273832398054585 no 947 0.269832170730975 277 235224 An aporphine alkaloid with mutagenic activity. SGTC_2054 5233173 129 µM 0.611602163522496 0.27441132943136 no 948 0.270400503158981 246 6889 SGTC_1991 st073000 8.92 µM 0.611461363541632 0.274458789500441 no 949 0.270447094570649 320 4301969 YIL048W NEO1 SGTC_2424 5537928 59.2 µM 0.611341511153859 0.274499191863515 no 950 0.27048675748054 298 5382802 SGTC_2237 6667747 47.222 µM 0.610481324213651 0.274789247850308 no 951 0.270771505545094 314 729940 YDL015C TSC13 SGTC_3326 9140064 16.379 µM 0.608017926859543 0.275620743173117 no 952 0.271587792104548 320 1868434 SGTC_3299 9121982 43.1275 µM 0.606892038558551 0.276001187076812 no 953 0.271961280994895 299 17594604 YPL160W CDC60 SGTC_3319 9138450 16.7555 µM 0.606709872727224 0.276062766151463 no 954 0.272021734538719 293 2029690 SGTC_3140 9094243 49.47 µM 0.606653987751642 0.276081658780008 no 955 0.272040281863377 311 19291112 SGTC_216 k038-0035 28.382 µM 0.606438279177412 0.276154587767069 no 956 0.272111877967649 309 4444231 YPR107C YTH1 SGTC_3329 9141233 27.5565 µM 0.606265515669401 0.276213004260464 no 957 0.27216922687596 305 4909101 YNL103W MET4 SGTC_1138 3761-0006 1.03 µM 0.604375946089892 0.276852319672021 no 958 0.272796862088113 293 12061087 SGTC_3058 9093861 49.47 µM 0.603746765401259 0.277065356862669 no 959 0.273006008569498 315 17217477 SGTC_2546 rhodinyl acetate 100 µM 0.601007888281418 0.277993659591302 no 960 0.273917366164851 290 6708682 SGTC_2252 omeprazole 400 µM 0.597441433407123 0.279204728065477 no 961 0.275106348903455 292 4594 A proton pump inhibitor. SGTC_2983 9022671 12.99 µM 0.597395460526635 0.279220355897888 no 962 0.275121691894102 314 6405161 SGTC_344 k064-0035 6.43 µM 0.597302861962794 0.279251834764355 no 963 0.275152597020983 305 5088750 SGTC_3049 9092223 49.47 µM 0.594596994068801 0.280172454860217 no 964 0.27605644492602 302 8623917 SGTC_410 α-linolenic acid 100 µM 0.59435507765428 0.280254833880728 no 965 0.276137323816666 295 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2605 digitonin 300 nM 0.593771039544463 0.280453762846604 no 966 0.276332630730048 310 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2743 auranofin 4.32 µM 0.593092809345329 0.28068486028345 no 967 0.276559521222043 262 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2084 5306078 60.6385 µM 0.59155446917197 0.281209369290778 no 968 0.277074485255677 334 679340 SGTC_473 2-arachidonoylglycerol 10 µM 0.591300945964006 0.281295855400452 no 969 0.277159397938484 297 5282280 An endocannabinoid. SGTC_1912 st060209 90.8 µM 0.587066565520195 0.282742253651732 no 970 0.27857950072403 329 688787 SGTC_1425 4048-4433 7.33 µM 0.586102523756547 0.283072053951512 no 971 0.278903310212514 347 23734946 SGTC_670 4204-0025 119 µM 0.585862133294199 0.283154320680322 no 972 0.278984082856876 314 719039 SGTC_1003 4049-0218 100 µM 0.585174713188416 0.283389633743832 no 973 0.279215122926001 309 295161 SGTC_2064 5220758 200 µM 0.585144810846198 0.283399871841553 no 974 0.279225175133938 292 788518 SGTC_2475 5812728 15.03 µM 0.584816185117654 0.283512399870103 no 975 0.27933566014578 307 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1309 pyrazolanthrone 13.4 µM 0.583495966800196 0.283964684728236 no 976 0.279779735672119 334 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_989 1501-0895 10.3 µM 0.582873088694705 0.284178192223832 no 977 0.279989369053431 306 2830112 SGTC_276 colchicine 750 µM 0.578011658215143 0.285847204616394 no 978 0.281628124158555 329 2833 A microtubule depolymerizer. SGTC_167 3672-0051 66.205 µM 0.577387145923532 0.286061947776326 no 979 0.281838977782653 313 3237971 SGTC_3020 9089140 49.47 µM 0.576887910886172 0.286233668541678 no 980 0.282007588835179 305 17217859 SGTC_2283 7944793 200 µM 0.576877034748817 0.286237410127237 no 981 0.28201126266964 303 2970533 SGTC_298 1391-0729 10 µM 0.576815215332508 0.286258677552075 no 982 0.282032144997317 311 3237558 SGTC_1042 0350-0096 82 µM 0.576111083758253 0.286500969348578 no 983 0.282270050085635 317 3122515 SGTC_548 1436-0017 110 µM 0.575861713300201 0.286586801092017 no 984 0.282354328086928 313 9677137 SGTC_3277 9138724 49.47 µM 0.573808619602104 0.287293926196694 no 985 0.283048657613857 297 15943418 SGTC_1478 0453-0656 35.7 µM 0.5734438617939 0.287419642143966 no 986 0.283172099628068 323 5258496 SGTC_631 k072-0230 41.5 µM 0.570969217632057 0.288273229283616 no 987 0.284010254608982 309 5773147 SGTC_1117 retinoic acid 1.10837 µM 0.569369371151798 0.288825705118376 no 988 0.284552749048959 321 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_831 k061-1017 217 µM 0.568842442920249 0.28900777857511 no 989 0.284731534242388 327 1240153 SGTC_1857 st056007 79.3 µM 0.56850983858044 0.289122733633414 no 990 0.284844413508039 302 619834 SGTC_1501 4491-0275 38.4 µM 0.568336318134109 0.289182714484331 no 991 0.284903311353282 326 5104718 SGTC_1750 st081859 2.357 µM 0.567313944661083 0.289536237273912 no 992 0.285250452300304 325 5291695 SGTC_2827 7993847 71.43 µM 0.567091019016783 0.289613348859616 no 993 0.28532617215595 303 2985692 SGTC_2076 5212012 200 µM 0.565539434003694 0.290150320175899 no 994 0.285853455051009 314 604802 SGTC_1475 4092-1048 11.7 µM 0.564414671468806 0.290539868542881 no 995 0.286235978175685 326 2881759 SGTC_813 k007-0158 173 µM 0.564104227186466 0.29064743037556 no 996 0.286341600688839 317 6523916 SGTC_553 k007-0256 45.7 µM 0.563988137609312 0.290687657539527 no 997 0.286381102618718 315 6287000 SGTC_719 2810-4230 27.3 µM 0.562199612686088 0.291307743021619 no 998 0.286990012643067 324 721079 SGTC_1712 st032288 53.4 µM 0.561147890869372 0.291672665271636 no 999 0.28734836138764 312 2883011 SGTC_3227 9130768 49.47 µM 0.558039991956202 0.292752274918926 no 1000 0.288408537892189 336 17720899 SGTC_1510 1123-0200 71.5 µM 0.558020329684803 0.292759111024391 no 1001 0.288415251015264 329 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2898 9056270 58.44 µM 0.557882402406176 0.292807067151771 no 1002 0.288462344430277 295 19154699 SGTC_1679 SEC14.276 6.7 µM 0.557778314987184 0.292843259865803 no 1003 0.288497886079461 336 1005053 YMR079W SEC14 SGTC_2161 5662504 8.5105 µM 0.554276439587197 0.294062121412307 no 1004 0.289694835948523 291 2859334 SGTC_2506 ethyl hematommate 54.16 µM 0.553734642189045 0.294250908498744 no 1005 0.289880231658959 325 3940691 An allergen. SGTC_2511 berberine 10.47 µM 0.551818161703471 0.294919147122641 no 1006 0.290536471404335 324 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1668 st014914 51.6 µM 0.551353039805883 0.295081431274214 no 1007 0.290695842854092 322 2839556 SGTC_1947 st076332 61.6 µM 0.550186728383665 0.295488545913955 no 1008 0.291095652725208 317 24208416 SGTC_1202 1988-0068 29.6 µM 0.549343014924196 0.295783214889867 no 1009 0.291385036478401 304 2850480 SGTC_2588 indole-3-carbinol 100 µM 0.549037628554625 0.295889905086836 no 1010 0.291489813471861 339 3712 Induces cell cycle arrest. SGTC_3162 9099653 49.47 µM 0.548833012337387 0.295961399972777 no 1011 0.29156002640916 294 25237511 SGTC_878 0828-0289 13.7 µM 0.547814266929324 0.29631747746433 no 1012 0.291909720654095 326 745350 YLR208W SEC13 SGTC_3151 9099821 49.47 µM 0.547630452048574 0.296381746365234 no 1013 0.291972837691692 328 17174189 SGTC_2746 daunorubicin 9.88 µM 0.54736736726354 0.296473742254208 no 1014 0.292063184915865 296 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_110 0850-0284 111.64 µM 0.547214893332184 0.296527065560399 no 1015 0.2921155526853 303 3906265 SGTC_3322 9139058 2.11 µM 0.547182705579011 0.296538322849115 no 1016 0.292126608253911 292 4908926 YPR165W RHO1 SGTC_982 1491-0518 27.5 µM 0.545241094073246 0.297217740506471 no 1017 0.292793855871069 323 3091256 SGTC_540 1187-0821 17.3 µM 0.544828221847076 0.297362306343043 no 1018 0.292935833320472 326 847520 SGTC_1578 josamycin 24.2 µM 0.543656849687741 0.29777263314927 no 1019 0.293338815597774 307 5282165 A P450 substrate. SGTC_2162 5663267 200 µM 0.540829273262227 0.298764184024319 no 1020 0.294312631914894 353 6456493 SGTC_973 1325-0077 65.9 µM 0.540554425460333 0.298860645328839 no 1021 0.294407368961504 331 2835149 SGTC_1118 chelidonine 707.474 nM 0.540315428381918 0.298944535869906 no 1022 0.294489760095801 314 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_318 1488-0629 67.2 µM 0.539374476814294 0.299274923877377 no 1023 0.294814244288915 349 3662576 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.538503192997677 0.299580997687617 no 1024 0.295114850664221 337 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1391 3442-0225 151 µM 0.538004722356577 0.299756169503443 no 1025 0.295286894188192 332 5227075 SGTC_1927 st060202 13.8 µM 0.536707390062615 0.300212293415903 no 1026 0.29573487527063 322 688887 SGTC_83 0170-0301 39.027 µM 0.535980817656432 0.300467883130515 no 1027 0.295985903925311 322 3089716 SGTC_975 1335-0046 28.5 µM 0.535752134375366 0.300548348430714 no 1028 0.296064933569054 336 16486740 SGTC_3265 9137266 49.47 µM 0.53571474304349 0.300561506001224 no 1029 0.296077856395216 309 17224265 SGTC_493 zm226600 134 µM 0.535665682214816 0.300578770325105 no 1030 0.296094812711295 335 5240098 A potassium channel opener. YCR052W RSC6 SGTC_286 k060-0067 22.9 µM 0.534289852864987 0.301063101796762 no 1031 0.296570505762777 309 5985051 SGTC_3196 9111891 49.47 µM 0.532430856687279 0.301718079972681 no 1032 0.297213809289963 339 18891510 SGTC_2184 6075246 200 µM 0.532429409117257 0.301718590243069 no 1033 0.297214310468363 320 2267320 SGTC_1122 capsaicin 818.572 nM 0.531117020658997 0.302181368485753 no 1034 0.29766884507183 355 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.530630304763345 0.302353076614476 no 1035 0.297837495586498 312 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2749 bexarotene 57.39 µM 0.530274092196393 0.302478772303389 no 1036 0.297960953380217 325 82146 An retinoic acid receptor inhibitor. SGTC_1426 4048-4480 71.7 µM 0.529631584928729 0.30270555118666 no 1037 0.298183695475131 317 14224343 SGTC_2190 6049624 200 µM 0.528242932106028 0.303195949049575 no 1038 0.298665367512015 329 2265554 SGTC_1115 galangin 695.678 nM 0.527901419214501 0.303316607532301 no 1039 0.298783879815249 351 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1442 4112-3290 3 µM 0.527067045137703 0.303611486954249 no 1040 0.299073515384043 331 704353 SGTC_2153 5569715 200 µM 0.524215664197666 0.304620169307412 no 1041 0.300064273576555 346 2054701 SGTC_1165 k072-0275 30.3 µM 0.523889161387669 0.304735765452517 no 1042 0.3001778169096 322 6153523 YGL055W OLE1 SGTC_1152 3909-8331 15.9 µM 0.523389543621972 0.304912689536944 no 1043 0.300351599617036 348 16001939 SGTC_2391 6285546 200 µM 0.522266147466412 0.305310671894282 no 1044 0.300742517925537 326 846083 SGTC_1103 duloxetine 36.1 µM 0.521047904464276 0.305742515619705 no 1045 0.301166700232862 332 60835 A selective serotonin reuptake inhibitor. SGTC_2567 aureobasidin a 60 nM 0.519961394273829 0.306127890659641 no 1046 0.301545241488527 361 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1981 st071826 47 µM 0.51968537952463 0.306225824726744 no 1047 0.301641439394606 321 11838600 SGTC_2894 9048625 32.47 µM 0.5185079597358 0.30664374593943 no 1048 0.302051953977128 361 4092861 SGTC_2185 6113692 200 µM 0.518444639891166 0.306666228238046 no 1049 0.302074037933995 336 874150 SGTC_2886 9058944 51.95 µM 0.516025852276755 0.307525585237575 no 1050 0.302918176658131 306 4949929 SGTC_2417 cerulenin 830 nM 0.515961742693424 0.307548376764018 no 1051 0.302940564779582 329 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3040 9091894 49.47 µM 0.511727513256785 0.309055324460563 no 1052 0.304420863827105 318 25236966 SGTC_1687 st020778 55.3625 µM 0.511655334438973 0.309081040626483 no 1053 0.304446125643713 315 4259299 SGTC_1688 st021091 57.6 µM 0.511079884154598 0.309286097875153 no 1054 0.30464756046838 353 3656366 SGTC_3073 9114972 49.47 µM 0.509713501697091 0.309773235618114 no 1055 0.305126096257105 336 41905075 SGTC_2676 harmalol 100 µM 0.50939574163508 0.309886570225573 no 1056 0.305237430300653 325 5459187 A monoamine oxidase inhibitor SGTC_2758 dehydroepiandrosterone 69.35 µM 0.506524976832402 0.310911296035083 no 1057 0.306244080138063 373 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1486 3970-0793 4.53 µM 0.506096196752124 0.31106447622723 no 1058 0.30639456017193 358 2844330 SGTC_1461 k072-0203 53.8 µM 0.504875452281914 0.311500762142819 no 1059 0.306823158265194 323 5418714 SGTC_709 3807-1509 243 µM 0.503587411659116 0.311961386387961 no 1060 0.307275670224573 360 1886677 YPL242C IQG1 SGTC_3117 9124945 49.47 µM 0.500955285357459 0.312903591905971 no 1061 0.308201296233882 327 17592065 SGTC_3096 9117468 49.47 µM 0.497982042371701 0.313969376395187 no 1062 0.30924834969179 328 41316311 SGTC_2341 7987486 176.74 µM 0.496690938091837 0.314432668193607 no 1063 0.309703506860178 343 1258686 SGTC_978 1416-0512 87.4 µM 0.494938633609358 0.315061921872587 no 1064 0.31032171937109 352 6814003 SGTC_953 1188-0045 9.7 µM 0.494721744092309 0.315139844428455 no 1065 0.31039827526346 355 6144426 SGTC_2386 9075165 157.42 µM 0.494610370962566 0.315179860988169 no 1066 0.310437590034646 335 16452277 SGTC_9 0092-0002 10.449 µM 0.494312024640786 0.315287068027315 no 1067 0.310542917107822 347 759368 SGTC_690 glyoxal 20.3 µM 0.494145349951152 0.31534696727674 no 1068 0.310601766082719 345 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1430 4049-0248 69.1 µM 0.491853556241514 0.316171079607799 no 1069 0.311411436392644 345 22774488 SGTC_381 3461-2219 42.7 µM 0.491273221448036 0.316379908976888 no 1070 0.311616608533992 370 2883159 SGTC_2761 levamisole 97.89 µM 0.490928042343679 0.31650414701703 no 1071 0.311738671249366 355 26879 An alkaline phosphatase inhibitor. SGTC_1652 st011932 78 µM 0.490449119967219 0.316676556687993 no 1072 0.311908062706137 334 1551076 SGTC_171 k064-0041 9.68 µM 0.48974554362138 0.316929912905048 no 1073 0.312156984843782 330 53325 SGTC_749 1000-0129 128 µM 0.487220639068826 0.317839831523025 no 1074 0.313050990354536 351 708470 SGTC_623 k072-0108 16.9 µM 0.486008868921489 0.318276917521557 no 1075 0.313480438912324 362 5382803 SGTC_2255 7941087 197.44 µM 0.485610103054918 0.31842080792169 no 1076 0.313621815968361 354 935561 SGTC_1673 st016611 27.3 µM 0.484817808436885 0.318706780238489 no 1077 0.313902794557299 371 5226799 SGTC_1641 st009299 47.1 µM 0.481813345355363 0.319792196975114 no 1078 0.314969274105397 338 4046054 SGTC_1487 3970-0795 2.82 µM 0.481433851974872 0.319929405921569 no 1079 0.315104091060567 334 3765103 SGTC_391 gliotoxin 8.33 µM 0.479599216955036 0.320593080470998 no 1080 0.315756201628598 347 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1291 0993-0025 5.79 µM 0.47577195511416 0.321979428536824 no 1081 0.317118425902965 346 4353356 SGTC_2539 epi(13)torulosol 80 µM 0.475597511515795 0.322042676461558 no 1082 0.317180574295536 323 6708597 SGTC_1499 4480-0877 67.3 µM 0.475396199361441 0.322115672511314 no 1083 0.317252301460515 354 2861909 SGTC_1390 3413-2614 145 µM 0.473879243254897 0.322665943293793 no 1084 0.317793010845759 371 3421432 SGTC_1334 1486-0610 236 µM 0.47204713423274 0.323331052795395 no 1085 0.318446572793684 333 3742339 SGTC_3260 9137109 49.47 µM 0.469701902133983 0.32418326549505 no 1086 0.319284004348275 331 17478346 SGTC_613 3914-0030 117 µM 0.468458206470841 0.32463557525132 no 1087 0.319728475862292 346 1145395 SGTC_1769 st044406 64.4 µM 0.467837129787986 0.324861546591098 no 1088 0.319950533036862 359 670903 SGTC_90 0870-0863 4.608 µM 0.467744849336704 0.324895127234301 no 1089 0.319983532113659 376 1738164 SGTC_201 4262-0159 12.803 µM 0.467343048273063 0.325041358296065 no 1090 0.320127230977857 356 1341029 SGTC_1609 st001574 46.4 µM 0.467020423222091 0.32515879363465 no 1091 0.320242633117191 380 3960012 SGTC_814 3342-0569 96 µM 0.466600006229484 0.325311851248401 no 1092 0.320393041272027 363 4346283 SGTC_1150 3909-7983 10.9 µM 0.462668699567395 0.326744511788648 no 1093 0.321800928661568 349 23965914 SGTC_837 0091-0265 12.5 µM 0.461092628458718 0.327319588777623 no 1094 0.322366075111286 364 759367 SGTC_3132 9126706 49.47 µM 0.460371951494539 0.327582686180302 no 1095 0.322624631892545 373 850858 SGTC_1938 st074717 56.4 µM 0.459907964757385 0.327752119056516 no 1096 0.322791141504513 344 17250979 SGTC_2953 9074162 66.49 µM 0.459652503144422 0.327845420477111 no 1097 0.322882833463616 365 16451992 SGTC_1770 st043884 66.3 µM 0.457237165171081 0.328728097044056 no 1098 0.323750293935882 346 670149 SGTC_2803 7707263 71.43 µM 0.456487754680078 0.329002161035227 no 1099 0.324019637210558 350 2199229 SGTC_19 0279-0214 38.434 µM 0.454512933489331 0.329724805295559 no 1100 0.324729842588696 349 3566274 YBR002C RER2 SGTC_1971 st069429 63.5 µM 0.453564155593067 0.330072217003193 no 1101 0.325071278730581 352 1246522 YGL099W LSG1 SGTC_2783 7738165 71.43 µM 0.452170563413265 0.330582771004594 no 1102 0.325573056320925 351 17201110 SGTC_1546 5-methoxyflavanone 78.7 µM 0.451207281793905 0.330935861612124 no 1103 0.325920080966901 333 147795 SGTC_1635 st007035 42.4 µM 0.449352068012367 0.331616313367297 no 1104 0.326588851281126 339 3716403 SGTC_1996 st072960 66.8 µM 0.44886223129294 0.331796067618971 no 1105 0.326765521522664 359 1719405 SGTC_3128 9127691 49.47 µM 0.445171673928824 0.333151625666463 no 1106 0.328097847711377 384 41316314 SGTC_136 0097-0015 404.482 µM 0.443771801601352 0.333666376935945 no 1107 0.328603788758693 339 4861337 SGTC_1523 st012844 44.7 µM 0.443601477324612 0.333729028783469 no 1108 0.328665368730157 339 4274103 SGTC_1441 4106-0040 13 µM 0.443568191532003 0.333741273125223 no 1109 0.328677403601389 352 2904180 SGTC_3012 9080433 71.4286 µM 0.44266231347399 0.334074572744792 no 1110 0.329005002692961 380 17688859 SGTC_3291 9121177 71.43 µM 0.442458487035048 0.334149584635088 no 1111 0.329078732005924 334 17015612 SGTC_247 mechlorethamine 29.705 µM 0.442407517784301 0.334168343295364 no 1112 0.329097169946146 356 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2797 7859098 81.82 µM 0.442060086503678 0.334296222509256 no 1113 0.329222863016637 341 972681 SGTC_2452 5863136 48.41 µM 0.440054079738007 0.33503495020389 no 1114 0.329948969734041 346 2184096 SGTC_846 0335-0850 148 µM 0.439116427379827 0.335380467228843 no 1115 0.330288588292079 363 6819598 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.439034539653291 0.335410648786306 no 1116 0.330318254747101 355 521171 SGTC_594 1487-1584 10.8 µM 0.438788790626862 0.33550123147616 no 1117 0.330407291615645 364 5013332 SGTC_1374 2889-5571 141 µM 0.43793676526054 0.335815360653968 no 1118 0.330716061651372 346 2853281 SGTC_2304 7443016 91.4 µM 0.437257872143473 0.336065740680689 no 1119 0.330962171862297 357 939854 SGTC_3119 9125183 49.47 µM 0.436575143638399 0.336317608598155 no 1120 0.331209746155282 344 22695334 SGTC_3250 9135583 49.47 µM 0.435778715961651 0.336611514553502 no 1121 0.331498643845473 340 7699353 SGTC_2201 6605497 169.863 µM 0.435454484536234 0.336731194383574 no 1122 0.331616284901315 346 670741 SGTC_3125 9127534 49.47 µM 0.435349899112264 0.336769802330356 no 1123 0.331654235228445 346 1639235 SGTC_1251 0490-5699 265 µM 0.434904642062973 0.336934189228626 no 1124 0.331815822494456 360 3883818 SGTC_326 k292-0812 17.5 µM 0.43480383201266 0.336971412171384 no 1125 0.331852411595811 383 3579357 SGTC_3251 9135047 49.47 µM 0.433797674176009 0.337343011728078 no 1126 0.332217685353723 359 17682963 SGTC_2129 girgensonine 121.053 µM 0.433591191296587 0.337419290721352 no 1127 0.332292666262797 369 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1615 st002656 86.5 µM 0.432923490293616 0.33766599883573 no 1128 0.3325351769943 343 1584458 SGTC_1211 1056-0033 32.3 µM 0.431573367187727 0.338165067450285 no 1129 0.333025759322205 348 6741922 SGTC_1642 st009582 77.7 µM 0.428412017043291 0.339334762042682 no 1130 0.334175588588172 379 6739311 SGTC_2181 6316240 54.2555 µM 0.427616700905222 0.33962927219788 no 1131 0.334465102396514 362 12779990 SGTC_992 3909-8734 162 µM 0.426921311326013 0.339886859240747 no 1132 0.334718321284015 367 4288319 SGTC_3039 9090270 49.47 µM 0.42680953196498 0.339928271664712 no 1133 0.334759031593301 344 17173750 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.423258134706049 0.34124500952577 no 1134 0.336053467849004 342 5282362 SGTC_1986 st071812 45 µM 0.42259480786235 0.34149116363512 no 1135 0.336295457726637 373 11838594 SGTC_1889 st059080 5.18 µM 0.420778805716275 0.342165409066087 no 1136 0.336958304739169 351 176925 Isolated from Daphnopsis sellowiana. SGTC_2408 sulbentine 18.36 µM 0.420568918242771 0.342243368605577 no 1137 0.337034947086626 341 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3093 9117344 49.47 µM 0.419651919600685 0.342584052756906 no 1138 0.33736987691667 353 24824913 SGTC_2316 5844804 197.44 µM 0.419345899264151 0.342697774224977 no 1139 0.337481678235287 375 776813 SGTC_250 brefeldin a 552.239 µM 0.418314749304872 0.343081068981903 no 1140 0.337858503629091 380 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_145 3737-0113 38.366 µM 0.417609041525077 0.343343484854987 no 1141 0.338116492544077 395 6849351 SGTC_115 0527-0192 112.043 µM 0.417586990635587 0.343351685647084 no 1142 0.338124555017261 390 4233931 SGTC_2144 5628481 200 µM 0.415870428745432 0.343990306252967 no 1143 0.338752409625969 349 2818399 SGTC_1852 st056254 31.4 µM 0.415861006872904 0.34399381274696 no 1144 0.338755857035781 386 442583 SGTC_944 3370-0224 231 µM 0.411657419241222 0.345559576508411 no 1145 0.340295269569566 343 4580514 SGTC_407 eburnamonine 100 µM 0.411594465513754 0.345583045859813 no 1146 0.340318344424193 351 3195 SGTC_2063 5246145 200 µM 0.411218768256537 0.345723119339794 no 1147 0.340456063704377 382 711240 SGTC_1581 himbacine 57.9 µM 0.41119691872943 0.345731266281196 no 1148 0.34046407373673 385 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2052 5265182 7.135 µM 0.410428636084049 0.34601777799939 no 1149 0.340745771735459 387 1239884 SGTC_132 0417-1715 25.805 µM 0.410059987495465 0.346155287548971 no 1150 0.340880971729594 393 6769098 SGTC_2095 5432005 200 µM 0.409298386823176 0.346439436320765 no 1151 0.341160349615365 384 783734 SGTC_1916 st067606 49.2 µM 0.407853436287619 0.346978776407479 no 1152 0.341690639932674 377 19590279 SGTC_2135 5326629 150.42 µM 0.407299225358505 0.347185722708764 no 1153 0.341894115833855 368 5020077 SGTC_265 mycophenolic acid 32.932 µM 0.406666331894322 0.347422105366713 no 1154 0.342126535830828 367 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1242 0402-0103 60.1 µM 0.400951787696483 0.349559137595177 no 1155 0.344227810168764 361 432868 SGTC_2239 6685329 187.64 µM 0.400725781482165 0.349643754349456 no 1156 0.34431101355902 329 805680 SGTC_2860 9025725 38.96 µM 0.399875712205372 0.349962087251566 no 1157 0.34462403101091 390 40546248 SGTC_3292 9120825 59.784 µM 0.396491951001074 0.351230277679725 no 1158 0.345871072274741 406 24824900 SGTC_1709 st033179 39.1045 µM 0.394447755423243 0.351997220579514 no 1159 0.346625246001363 372 573381 SGTC_1571 st070080 73.4 µM 0.39382250413715 0.352231923317367 no 1160 0.346856044223014 350 4315245 SGTC_3172 9105863 49.47 µM 0.392627509904379 0.352680648975362 no 1161 0.347297309002223 376 2348785 SGTC_374 0880-0231 82.3 µM 0.392225401638499 0.3528316885596 no 1162 0.347445838498993 389 6833587 SGTC_2528 xanthyletin 44.79 µM 0.39110154978409 0.353253951845228 no 1163 0.347861087566461 383 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3254 9136651 49.47 µM 0.390079413390541 0.353638154678542 no 1164 0.34823891258975 393 16454030 SGTC_2967 9089538 49.85 µM 0.389936684995467 0.353691815611455 no 1165 0.348291683063021 375 728216 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.389740464881027 0.353765592323746 no 1166 0.348364235637925 365 688664 SGTC_2337 9009472 200 µM 0.389138076862252 0.353992118224757 no 1167 0.348587003837768 403 5742383 SGTC_2965 9082772 38.63 µM 0.389040859965186 0.354028681143989 no 1168 0.348622960367225 331 16459634 SGTC_1816 st051957 91.6 µM 0.388860489701136 0.354096521305363 no 1169 0.348689675507149 368 674121 SGTC_2214 7179297 48.276 µM 0.387743654777451 0.354516683955426 no 1170 0.349102873209139 381 769744 SGTC_887 0885-0007 9.62 µM 0.387738756070551 0.354518527280437 no 1171 0.349104685988304 400 5719458 SGTC_1383 3049-0032 20.7 µM 0.384629839323941 0.355689061193632 no 1172 0.350255841603696 413 712864 SGTC_3103 9120822 49.47 µM 0.384435734844463 0.355762188489869 no 1173 0.350327759511662 406 17141819 SGTC_1411 3909-8223 150 µM 0.38419682060729 0.355852204788362 no 1174 0.350416287310279 397 X1411 SGTC_2906 7926292 26.41 µM 0.383700997792314 0.356039042800508 no 1175 0.35060003649674 395 2966319 SGTC_1160 4092-0570 10.5 µM 0.383587181104246 0.356081936558567 no 1176 0.350642221265558 371 4994975 SGTC_2791 5663188 71.43 µM 0.383012195758796 0.3562986574164 no 1177 0.350855360723538 423 54690634 SGTC_255 tunicamycin 200.472 nM 0.382624531849164 0.35644480013643 no 1178 0.35099908910285 358 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2913 7966556 36.57 µM 0.3821967469601 0.356606092253425 no 1179 0.351157717284785 400 2976516 SGTC_2094 5332512 191.667 µM 0.381203762065977 0.356980586330309 no 1180 0.351526028892924 393 755774 SGTC_77 0828-0286 12.516 µM 0.380802580429053 0.357131926991915 no 1181 0.351674872187384 347 745345 SGTC_254 nsc-64875 3.808 µM 0.380678661660476 0.357178678314167 no 1182 0.351720852164186 386 56993 SGTC_2364 9055074 200 µM 0.378110999381131 0.358147871969077 no 1183 0.352674068762114 373 6470630 SGTC_1161 k007-0610 110 µM 0.376076140604047 0.358916602962237 no 1184 0.353430145772812 381 5843850 SGTC_181 1447-1644 8.07 µM 0.375699138663134 0.359059090002699 no 1185 0.353570289152427 390 534600 SGTC_1238 0333-0287 48.8 µM 0.37355233501716 0.359870842871307 no 1186 0.3543687008842 371 7226 SGTC_904 1141-0088 396 µM 0.372435125124613 0.36029353453722 no 1187 0.354784452892865 379 1378119 SGTC_233 rapamycin 362 pM 0.371487517307323 0.360652191892947 no 1188 0.355137225805922 359 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1875 nocodazole 6 µM 0.371089012923252 0.360803057312143 no 1189 0.35528561707166 379 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3129 9127257 49.47 µM 0.370893137059769 0.360877219756859 no 1190 0.355358563505264 399 837894 SGTC_544 k015-0020 52.4 µM 0.370470336017594 0.361037318355858 no 1191 0.355516037558668 363 3008304 SGTC_1513 0337-0559 19 µM 0.368993193761721 0.361596846649734 no 1192 0.356066398979547 373 775073 SGTC_2072 5231554 129 µM 0.367564383351139 0.362138349014908 no 1193 0.356599038171389 402 789545 SGTC_2390 9097792 176.6 µM 0.366854171012531 0.362407613924262 no 1194 0.356863898894795 381 4497149 SGTC_579 4491-1009 110 µM 0.364828246028316 0.363176082570905 no 1195 0.35761980946917 418 1271041 SGTC_660 4031-1742 102 µM 0.362899473768351 0.36390821170934 no 1196 0.358339989931541 391 6738706 SGTC_1121 fusaric acid 630.51 nM 0.361867373506423 0.364300183755317 no 1197 0.358725571071147 350 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2905 7799065 20.05 µM 0.360728167769947 0.364732997249248 no 1198 0.35915133283771 403 1296806 SGTC_1965 Pectolinarigenin 58.4 µM 0.360349862428612 0.364876763327263 no 1199 0.359292757750101 379 5320438 An anti-inflammatory. SGTC_1785 bathophenanthroline 24 µM 0.359648772913297 0.36514324618559 no 1200 0.359554902614912 372 72812 An iron chelator. SGTC_2608 thymoquinone 42.66 µM 0.359459810950297 0.365215081435589 no 1201 0.359625568827612 376 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1744 st037937 38.9 µM 0.358520753270229 0.365572141079851 no 1202 0.359976819919038 361 1016152 SGTC_1564 D-Arginine 115 µM 0.356489869476519 0.366344745915263 no 1203 0.360736868715224 389 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1186 1319-0216 26 µM 0.354307851785554 0.367175450357041 no 1204 0.361554092029864 385 4565136 SGTC_2003 4023581 200 µM 0.351790754868992 0.368134493714174 no 1205 0.36249759624241 387 16641307 SGTC_635 k038-0028 24.7 µM 0.351754618502414 0.368148268094439 no 1206 0.362511147633397 406 4035102 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.351708048818945 0.368166019673334 no 1207 0.362528611845446 383 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2776 terbinafine 19.92 µM 0.351197236886424 0.368360751046936 no 1208 0.362720191459522 366 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_120 rhodamine 6G 52.259 µM 0.349153341185419 0.369140261494032 no 1209 0.363487096410565 406 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_385 1494-0393 12.4 µM 0.349068023372266 0.369172812127531 no 1210 0.363519121050178 401 3090647 SGTC_647 0140-0236 81 µM 0.346532422435842 0.370140627282074 no 1211 0.364471311129018 393 990837 SGTC_1874 staurosporine 7.6 µM 0.343139150632614 0.371437093924548 no 1212 0.365746889594186 401 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2875 9039966 71.43 µM 0.343103401950835 0.371450760212504 no 1213 0.365760335958479 414 6463691 SGTC_815 1582-0027 36.9 µM 0.342772920941848 0.371577106770099 no 1214 0.365884649553809 397 3128206 SGTC_2037 5169046 200 µM 0.342569781828063 0.371654775975095 no 1215 0.365961069265679 373 5718022 SGTC_607 4491-0986 66.8 µM 0.34161186858766 0.372021099583439 no 1216 0.36632150208216 383 698981 YDR232W HEM1 SGTC_733 4069-0007 56.1 µM 0.340141449349828 0.372583640243845 no 1217 0.366875004308135 385 5717425 YNL287W SEC21 SGTC_1530 rhein 70.4 µM 0.337591969306507 0.373559642771046 no 1218 0.367835347408191 399 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1413 3910-0535 34.4 µM 0.337155512661836 0.373726810446047 no 1219 0.367999835797274 403 2876951 SGTC_1192 1488-0095 21.4 µM 0.336666826942416 0.373914010620942 no 1220 0.368184036598227 402 915875 SGTC_3036 9090181 49.47 µM 0.335148109986446 0.374495973135714 no 1221 0.368756681391414 399 25236586 SGTC_3195 9113082 49.47 µM 0.334978513605788 0.374560979149436 no 1222 0.368820647227965 414 17018038 SGTC_56 0957-0365 83.25 µM 0.334221085879089 0.374851343445263 no 1223 0.369106366869335 392 6752360 SGTC_443 clozapine 122 µM 0.334057633839128 0.374914013043436 no 1224 0.369168034336886 430 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1949 st076024 69.1 µM 0.333702416671092 0.375050219226083 no 1225 0.369302062891298 427 2921930 SGTC_2737 bleomycin 30.5 nM 0.333586098296547 0.375094824291991 no 1226 0.369345954943512 414 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2705 st078069 42.8 µM 0.330775584018269 0.376173089797563 no 1227 0.370407002416388 394 1530061 SGTC_932 2857-0803 154 µM 0.329968188221336 0.376483029780779 no 1228 0.37071199963393 407 674898 SGTC_2330 7979373 200 µM 0.329867557612598 0.376521665056921 no 1229 0.370750018976232 370 1863007 SGTC_1065 prochlorperazine maleate 2.48 µM 0.32967623811346 0.376595122080022 no 1230 0.370822305051497 428 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2433 5607874 27.82 µM 0.32946795587695 0.376675097017913 no 1231 0.370901005326353 402 2252428 SGTC_2941 9056145 11.23 µM 0.327796354637311 0.377317139662103 no 1232 0.37153282187973 437 2119517 SGTC_1059 3448-6867 171 µM 0.327249676938156 0.377527185927101 no 1233 0.37173952533979 403 3934407 SGTC_1275 0867-0008 21.1 µM 0.327061141471306 0.377599634035707 no 1234 0.371810820773129 406 3422836 SGTC_1552 6-methylflavone 10.6 µM 0.32692407566842 0.377652306713636 no 1235 0.371862655509282 421 689013 SGTC_3037 9091026 49.47 µM 0.326306570365899 0.377889634499656 no 1236 0.372096208810904 398 25236398 YIL048W NEO1 SGTC_2277 7947813 106.88 µM 0.324722263216846 0.378498746984888 no 1237 0.372695641695757 423 1246798 SGTC_196 k015-0023 18.111 µM 0.324204077176405 0.378698037598645 no 1238 0.37289176775494 387 5211998 SGTC_2912 7964298 10.93 µM 0.323784067869156 0.378859593822703 no 1239 0.373050759495046 401 2975850 SGTC_662 k832-1615 104 µM 0.322738761000636 0.379261762065334 no 1240 0.373446547303486 434 5878478 SGTC_1932 st074806 40.9 µM 0.322406826086907 0.379389497075065 no 1241 0.37357225681308 437 17251235 SGTC_61 0978-8327 98.565 µM 0.322271420398937 0.379441607598837 no 1242 0.373623541160093 405 6150059 YHR072W ERG7 SGTC_1342 1486-1464 234 µM 0.322225498273523 0.379459281105722 no 1243 0.37364093448433 418 3253938 SGTC_1459 k035-0031 35.7 µM 0.321782218671704 0.379629893844148 no 1244 0.373808842943216 392 3877128 YMR208W ERG12 SGTC_246 cycloheximide 667 µM 0.315940570228296 0.381880448668204 no 1245 0.376023808647035 404 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2618 avocadyne 43.43 µM 0.315675807929726 0.381982546325766 no 1246 0.376124295459028 417 3015189 SGTC_1030 k029-0042 36.7 µM 0.314805670367494 0.382318146620386 no 1247 0.37645460307611 394 6080581 SGTC_2924 9010168 62.78 µM 0.313996244093531 0.38263041078044 no 1248 0.376761945696983 390 2993929 SGTC_2987 9018338 71.43 µM 0.313652333297234 0.382763109370635 no 1249 0.37689255375709 416 5055682 SGTC_2747 doxorubicin 7.63 µM 0.313620303802949 0.38277546870861 no 1250 0.376904718413982 415 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2297 7971671 152.32 µM 0.312115642513368 0.383356212176146 no 1251 0.377476319469399 407 909016 SGTC_3318 9139014 38.6185 µM 0.311678952677961 0.383524807408564 no 1252 0.37764226252348 437 16643984 SGTC_1753 st043925 64 µM 0.310606046566313 0.383939123740597 no 1253 0.378050064960422 411 670181 SGTC_2849 9019321 12.99 µM 0.309759015457456 0.384266309323355 no 1254 0.378372110273911 392 16489627 SGTC_311 1315-0136 58 µM 0.30823531235518 0.384855082797779 no 1255 0.378951642144595 413 6759207 SGTC_336 4111-0029 111 µM 0.308109791501583 0.384903597118389 no 1256 0.378999395446491 422 3131175 SGTC_595 3909-8003 73.7 µM 0.306230651587161 0.385630107366301 no 1257 0.379714518063176 422 699517 SGTC_1279 0874-0590 65.2 µM 0.306044759856324 0.385701998408779 no 1258 0.379785283148224 416 3523074 SGTC_209 4077-0173 175.592 µM 0.305507902403007 0.385909642600966 no 1259 0.379989676121982 407 15993494 SGTC_1424 4048-1941 275 µM 0.304473193430692 0.386309936558836 no 1260 0.3803837062168 445 X1424 SGTC_1881 5652484 16 µM 0.304161051789341 0.38643071740171 no 1261 0.380502598044767 431 2255129 SGTC_51 1013-0126 23.419 µM 0.303666216781926 0.386622212604079 no 1262 0.380691099192876 433 1627850 SGTC_109 0132-0036 33.701 µM 0.303434346420053 0.386711953151277 no 1263 0.380779437028778 439 67274 A color developer. SGTC_2954 9074818 52.69 µM 0.302939981310761 0.386903306991762 no 1264 0.380967800708584 424 16648742 SGTC_2002 4023503 131 µM 0.300744392771214 0.387753484776806 no 1265 0.381804707202271 440 4736863 YCR052W RSC6 SGTC_1493 4348-0038 111 µM 0.300285403320606 0.387931283266426 no 1266 0.381979733123316 435 800424 SGTC_564 3555-0129 330 µM 0.298581447317748 0.388591549016823 no 1267 0.382629711474004 423 563260 SGTC_1326 1431-2094 10.8 µM 0.298451379819191 0.388641962111453 no 1268 0.382679339661914 440 616278 SGTC_677 0929-0063 136 µM 0.296326439061902 0.389465836745997 no 1269 0.383490398349211 417 1539583 SGTC_2402 5553605 200 µM 0.295350753587755 0.38984429285955 no 1270 0.383862974507031 402 6758546 SGTC_2836 9010338 19.48 µM 0.291678916226123 0.391269485851809 no 1271 0.385266065499348 395 2994051 SGTC_2220 6782180 200 µM 0.289872451323439 0.391971187569182 no 1272 0.38595690893059 424 833803 SGTC_2602 kawain 100 µM 0.28985421849764 0.39197827170844 no 1273 0.385963883528475 423 5369129 SGTC_2470 5664817 21.68 µM 0.289494539351634 0.39211802791614 no 1274 0.386101479027158 408 2859561 SGTC_1811 st050069 61.5 µM 0.28917591825021 0.392241842318871 no 1275 0.386223379711764 446 3877702 SGTC_457 grayanotoxin iii 135 µM 0.288919024661057 0.392341677695876 no 1276 0.386321672355848 400 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2846 9008642 19.48 µM 0.288187165480962 0.392626135600551 no 1277 0.386601736348022 437 2992898 SGTC_504 lovastatin 124 µM 0.287172548068962 0.39302059040767 no 1278 0.386990102452848 434 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1604 st002052 72.4 µM 0.286676414483135 0.393213513261738 no 1279 0.387180049217173 386 6254834 YHR062C RPP1 SGTC_756 0508-1999 28.3 µM 0.286448847977735 0.393302011874486 no 1280 0.387267183021775 407 6753853 SGTC_1622 st003707 19.4 µM 0.286282145530422 0.393366844489313 no 1281 0.38733101596046 422 10140899 SGTC_2030 5175110 200 µM 0.286116961249731 0.393431089587329 no 1282 0.387394270574673 435 2831986 SGTC_89 0302-0250 142.109 µM 0.285994212190117 0.393478832240432 no 1283 0.387441277252476 427 4203518 YLR208W SEC13 SGTC_186 3455-3465 67.277 µM 0.285945648123265 0.393497721441594 no 1284 0.387459875288006 436 755278 SGTC_4 0960-0234 25.671 µM 0.284562780772601 0.394035698630567 no 1285 0.387989564701785 382 6821112 SGTC_3290 9121031 71.43 µM 0.283528309492271 0.394438271522383 no 1286 0.388385941878685 410 17014854 SGTC_2955 9076254 12.21 µM 0.281287851273066 0.395310550108276 no 1287 0.389244813791132 424 16459619 SGTC_923 1900-2434 73.3 µM 0.280798652459397 0.395501080054301 no 1288 0.389432418620975 460 5910570 SGTC_634 1611-4317 11.2 µM 0.279994737500071 0.395814237814704 no 1289 0.389740771173775 431 2843522 SGTC_737 1950-0117 57.9 µM 0.279988727205745 0.395816579323761 no 1290 0.389743076765834 402 5393513 SGTC_3010 9080089 71.4286 µM 0.278882947753215 0.396247436197311 no 1291 0.390167327645842 412 17027233 SGTC_787 4152-0075 138 µM 0.27839606739122 0.39643718491167 no 1292 0.390354169003073 398 9566539 SGTC_421 streptovitacin 30 mM 0.278169912379617 0.396525331179 no 1293 0.390440965078772 411 91467 include heat shock SGTC_3208 9114115 49.47 µM 0.277968846718559 0.396603703052413 no 1294 0.390518136693301 439 650895 SGTC_1469 k284-2957 126 µM 0.277868585294408 0.396642784760732 no 1295 0.390556619943096 410 23884841 SGTC_2994 9053520 71.4286 µM 0.277640891794546 0.396731543100571 no 1296 0.390644019310363 441 4647384 SGTC_1727 st034309 9.9045 µM 0.276617016378731 0.397130731152694 no 1297 0.391037098594303 446 870305 SGTC_2586 curcumin 80 µM 0.276328579613235 0.397243206217801 no 1298 0.391147853393078 403 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1331 1472-0049 76.2 µM 0.276297917017254 0.397255163509261 no 1299 0.391159627826256 422 24051409 SGTC_725 1497-0963 19 µM 0.276273770632718 0.397264579784445 no 1300 0.391168900105229 440 3549977 SGTC_3261 9137475 49.47 µM 0.27600448817143 0.397369594914045 no 1301 0.391272309511251 432 17027690 SGTC_729 4092-0585 94.1 µM 0.275911586818678 0.397405826432668 no 1302 0.391307987118866 391 2169061 SGTC_414 piperonyl butoxide 100 µM 0.27479570773461 0.397841088255492 no 1303 0.391736597966755 431 5794 A potent inhibitor of cytochrome P450. SGTC_1877 wortmannin 25 µM 0.273902135065646 0.398189728569325 no 1304 0.392079915383563 438 312145 A covalent inhibitor of PI 3-kinase. SGTC_302 1094-0063 18.9 µM 0.273076519152071 0.398511926836836 no 1305 0.39239719799778 424 5440289 SGTC_2753 fluvastatin 17.09 µM 0.272320776002185 0.398806917780837 no 1306 0.392687691363388 417 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3209 9113616 49.47 µM 0.272032784326234 0.398919345450009 no 1307 0.392798405655772 443 16649353 SGTC_1988 st071872 53.4 µM 0.271813766324948 0.399004852436855 no 1308 0.392882609809794 436 16414116 SGTC_3071 9117417 49.47 µM 0.269808204729897 0.399788070186046 no 1309 0.393653905190811 438 45595590 YGL055W OLE1 SGTC_694 1315-0438 43.2 µM 0.268944076294235 0.400125656662501 no 1310 0.393986359054798 427 6793154 SGTC_3181 9108277 49.47 µM 0.268093846034997 0.400457886437499 no 1311 0.394313541328854 440 17097298 SGTC_842 0271-0008 11.1 µM 0.267892211761219 0.400536686151727 no 1312 0.394391144389213 424 1221709 SGTC_162 k030-0015 37.8 µM 0.267372978385589 0.400739623860953 no 1313 0.394591001227069 432 1809920 YMR134W ERG29 SGTC_2411 st077133 39.94 µM 0.267357748235529 0.400745576833274 no 1314 0.394596863845693 458 1403142 YNL221C POP1 SGTC_402 epigallocatechin gallate 10 µM 0.267096771702339 0.400847587687017 no 1315 0.394697326569575 434 65064 An antioxidant. SGTC_2984 9022109 38.96 µM 0.266917405732577 0.400917702416335 no 1316 0.394766377428248 442 6459207 SGTC_425 3825-7017 13.1 µM 0.266182452012685 0.40120503147824 no 1317 0.395049348463845 466 3397440 SGTC_451 chloral hydrate 100 µM 0.264779565778317 0.40175363599489 no 1318 0.39558963968733 438 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3338 9144300 39.5675 µM 0.263667847509116 0.402188515665416 no 1319 0.396017936491527 405 4901274 SGTC_343 4130-2827 29.8 µM 0.263314891386187 0.402326609670464 no 1320 0.396153941452476 399 1118244 SGTC_2745 rifampicin 24.3 µM 0.263221735537539 0.402363058909711 no 1321 0.396189839404476 449 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.263181707493675 0.402378721007804 no 1322 0.396205264630128 426 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2519 cryptotanshinone 88.04 µM 0.262953040544209 0.402468196387871 no 1323 0.396293386947449 407 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_779 1360-0071 233 µM 0.262936658883123 0.402474606584966 no 1324 0.396299700218618 442 7566 SGTC_1545 lovastatin 49.4 µM 0.261991744437927 0.402844398997852 no 1325 0.396663903469298 419 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2644 guaiazulene 100 µM 0.261563965146945 0.403011839093497 no 1326 0.396828814319217 438 3515 A coloring agent. SGTC_1882 5615643 20 µM 0.260304357743602 0.403504974056178 no 1327 0.39731450572448 426 2253075 SGTC_2809 7964133 12.99 µM 0.259564059259597 0.403794871778384 no 1328 0.397600031415402 445 1253665 SGTC_1924 st058459 75.1 µM 0.259368591658128 0.403871424882568 no 1329 0.397675430468955 443 688683 SGTC_2571 chrysanthemic acid 100 µM 0.258464876002904 0.404225404702404 no 1330 0.398024076534143 436 2743 An insecticide. SGTC_984 1492-0255 2.91 µM 0.256932450896275 0.404825825223992 no 1331 0.398615459539923 442 1585198 SGTC_3057 9095946 49.47 µM 0.256707702749419 0.404913902829022 no 1332 0.3987022124199 430 24540043 SGTC_1903 st060211 78.3 µM 0.256371411160611 0.40504570271202 no 1333 0.398832030462502 416 688960 SGTC_2043 5101342 149 µM 0.255837865383727 0.405254832835231 no 1334 0.399038017148319 420 678451 SGTC_1737 st035557 69.7 µM 0.255534183933716 0.405373876767618 no 1335 0.399155272386519 417 5716916 SGTC_2817 7995342 71.43 µM 0.255229521362061 0.405493314099093 no 1336 0.39927291559177 418 18879975 SGTC_1221 2958-7315 257 µM 0.254352313891526 0.405837256188516 no 1337 0.399611693841859 415 4562705 SGTC_537 1334-0398 209 µM 0.25422435490687 0.40588743338975 no 1338 0.399661118031235 433 5846986 SGTC_3148 9097893 49.47 µM 0.253398578854983 0.406211286263774 no 1339 0.399980112869922 381 17174100 SGTC_3302 9125395 16.351 µM 0.253239425987856 0.406273710222795 no 1340 0.400041600829482 431 17599668 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.252817620873209 0.406439164852605 no 1341 0.400204575230053 423 688803 SGTC_258 haloperidol 50.781 µM 0.251946852748771 0.406780779709077 no 1342 0.400541072072073 442 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2949 9072542 2.23 µM 0.25145312670273 0.406974507070622 no 1343 0.400731898796734 415 16457352 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.250997934058099 0.407153134932368 no 1344 0.400907853228182 461 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1859 st055998 20 µM 0.248870972633597 0.407988057953275 no 1345 0.401730294726559 435 676301 SGTC_1094 duloxetine 25.4 µM 0.248333359000764 0.408199160547672 no 1346 0.401938245229479 428 60834 A selective serotonin reuptake inhibitor. SGTC_1926 methyl fluorone black 53.6 µM 0.247534419016537 0.408512926323067 no 1347 0.402247328790548 423 72721 Reacts with homocysteine. SGTC_3055 9094636 49.47 µM 0.24694819361776 0.408743190532703 no 1348 0.402474158980748 449 25236176 SGTC_218 alverine citrate 93.75 µM 0.24614682267788 0.40905801298254 no 1349 0.402784289283501 452 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1146 3579-1023 7 µM 0.244615097789793 0.409659921604779 no 1350 0.403377236405269 435 X1146 SGTC_1691 st019933 84.6 µM 0.24412169834841 0.409853853917893 no 1351 0.403568283997728 463 6176082 SGTC_2857 9024691 58.44 µM 0.242619539984657 0.41044441791932 no 1352 0.40415007135254 457 16478292 SGTC_2630 antimycin a 100 µM 0.242189171322632 0.410613652112674 no 1353 0.404316792679647 425 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1722 st034304 3.6505 µM 0.241679073955576 0.410814259636278 no 1354 0.404514422763517 444 4036148 YLR033W RSC58 SGTC_1440 4100-1550 40 µM 0.241485310128506 0.410890467835571 no 1355 0.404589500233893 453 742806 SGTC_2291 7917025 104.35 µM 0.241451852056459 0.410903627388942 no 1356 0.40460246455434 428 2964612 SGTC_1356 1502-0781 85.8 µM 0.24004787975407 0.411455920621863 no 1357 0.405146569420637 415 567702 SGTC_2544 sphondin 68.51 µM 0.239400754207844 0.411710545384675 no 1358 0.405397422617652 440 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_991 3996-0057 64.7 µM 0.239030923036047 0.411856079716886 no 1359 0.405540802261115 398 715343 SGTC_2770 toltrazuril 17.5 µM 0.238904843013569 0.411905696943905 no 1360 0.405589685053765 440 68591 Kills coccidiodes. SGTC_3018 9082602 49.47 µM 0.238868941299378 0.411919825875318 no 1361 0.405603604864198 436 17332089 SGTC_997 3996-0078 137 µM 0.238158842196821 0.412199305096463 no 1362 0.405878948953697 427 735687 SGTC_1745 st081495 74 µM 0.237482600420276 0.412465500228135 no 1363 0.406141208007643 441 13842402 YBL026W LSM2 SGTC_2612 dictamnine 15.46 µM 0.237325462634288 0.412527361558193 no 1364 0.406202154979176 456 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2951 9072950 58.06 µM 0.237007280230424 0.412652628896044 no 1365 0.40632557117314 460 16488155 SGTC_1995 st072814 61.1 µM 0.236081978657015 0.413016967511927 no 1366 0.406684528840006 415 5769371 SGTC_799 1310-0557 151 µM 0.235626186860211 0.413196463650681 no 1367 0.406861375672312 452 5354492 SGTC_1347 1493-0251 600 nM 0.234042920949472 0.413820113042053 no 1368 0.407475828867636 436 3986378 SGTC_1650 st011916 45.8 µM 0.234038701817925 0.413821775251663 no 1369 0.407477466584685 457 242528 SGTC_688 0527-0193 473 µM 0.232179598970458 0.414554355101817 no 1370 0.40819926125109 445 4007154 SGTC_422 cantharidin 155 µM 0.23137478736272 0.414871583639402 no 1371 0.408511825276654 428 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.231204695294307 0.414938635086884 no 1372 0.408577891251577 413 6857784 SGTC_2813 7971799 71.43 µM 0.229504154107561 0.415609135880811 no 1373 0.409238546139 446 2234054 SGTC_2372 9071633 200 µM 0.229419254565976 0.415642617099692 no 1374 0.409271536117168 444 21321366 SGTC_1169 aniline yellow 25.8 µM 0.227710004036037 0.416316811841018 no 1375 0.409935847323143 460 6051 A DNA damaging agent. SGTC_2303 7774051 200 µM 0.227597417944477 0.416361228831895 no 1376 0.409979613729613 450 2953184 SGTC_2717 st081029 62.2815 µM 0.226951093617843 0.416616234632936 no 1377 0.410230885747276 475 5292846 SGTC_3263 9137018 49.47 µM 0.225165333703723 0.417320984288812 no 1378 0.410925328346691 469 43844957 SGTC_1283 0922-0125 16.4 µM 0.2244473409036 0.417604414967025 no 1379 0.41120461873059 435 3360884 SGTC_576 1073-0113 22.7 µM 0.222691110341139 0.418297874511017 no 1380 0.411887960282628 459 5439563 SGTC_2931 9014674 55.67 µM 0.22262404220623 0.418324361868291 no 1381 0.411914061509246 428 2996810 SGTC_1088 bifonazole 369 nM 0.222586820726821 0.418339061983986 no 1382 0.411928547338458 454 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.222236069601944 0.418477591956396 no 1383 0.412065058306382 441 676296 Flavone; oxidizing agent. SGTC_359 0081-0058 15.9 µM 0.217476107047817 0.420358543053372 no 1384 0.413918662617649 482 3494159 SGTC_937 3122-0005 46.7 µM 0.216953215146281 0.420565281220746 no 1385 0.414122402706023 465 759535 SGTC_2032 5185112 25.99 µM 0.216732506560107 0.420652550365813 no 1386 0.414208406745731 468 5718189 SGTC_2739 tacrine 100.86 µM 0.216513172761198 0.420739279777494 no 1387 0.414293879144541 453 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3149 9097855 49.47 µM 0.216052675411945 0.420921383078626 no 1388 0.414473344001569 486 25236625 YMR079W SEC14 SGTC_440 fluspirilene 35.1 µM 0.215400434596998 0.421179340124722 no 1389 0.414727565599239 450 3396 An atypical antipsychotic. SGTC_2575 plumbagin 510 nM 0.214156918037858 0.421671236590477 no 1390 0.415212345533973 458 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2698 st077697 67.5 µM 0.212638366284204 0.422272094149274 no 1391 0.415804521875212 461 3154499 SGTC_935 2996-0153 430 µM 0.211707789969714 0.422640392253505 no 1392 0.416167505169519 472 23738523 SGTC_2734 clemastine 41.6 µM 0.211462894536398 0.422737326804751 no 1393 0.416263041691407 466 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1724 st037281 8.293 µM 0.211292345425046 0.422804836346475 no 1394 0.416329577781918 432 574124 YDL195W SEC31 SGTC_74 000s-0487 160.283 µM 0.211250299221882 0.422821480111493 no 1395 0.416345981577892 371 677548 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.210799389873924 0.422999978824261 no 1396 0.416521907328271 425 16486 A toxic proline analog. SGTC_1835 st008666 49.2 µM 0.210363341536063 0.423172609636352 no 1397 0.416692050846759 434 690455 SGTC_1467 k284-1082 293 µM 0.210103839623859 0.423275353015804 no 1398 0.41679331438967 438 3334705 SGTC_751 0833-0568 350 µM 0.207693279708743 0.42423000318867 no 1399 0.417734232640052 461 6954252 SGTC_2704 st078022 71.1 µM 0.206203527637608 0.424820210029956 no 1400 0.418315966202991 462 54697681 SGTC_2963 9082507 9 µM 0.206153783170057 0.424839920604197 no 1401 0.418335394019896 451 16459611 SGTC_1723 st034307 2.5525 µM 0.205831406740373 0.424967662468671 no 1402 0.418461303707777 442 867466 SGTC_2324 6149169 200 µM 0.205811070987223 0.424975720788063 no 1403 0.418469246468011 475 2888231 SGTC_1239 0337-0584 35.4 µM 0.205529356700005 0.425087357138379 no 1404 0.418579282154592 462 914301 YML130C ERO1 SGTC_1028 k015-0029 4.8 µM 0.205454404450582 0.425117059858804 no 1405 0.418608559067395 465 4588309 SGTC_483 fpl-64176 144 µM 0.204379651074288 0.425543019015887 no 1406 0.419028415331085 456 3423 SGTC_667 1498-1044 59 µM 0.20394573966772 0.425715016649022 no 1407 0.419197950541637 477 6739982 SGTC_865 0488-0499 301 µM 0.203464739095425 0.425905696419737 no 1408 0.419385901675952 459 9634651 SGTC_2024 5144227 134 µM 0.202532268834504 0.426275398548718 no 1409 0.419750317101186 444 3475211 SGTC_2996 9066192 71.4286 µM 0.201044634574126 0.426865343931325 no 1410 0.420331836587103 444 6472854 SGTC_2442 5158906 48.48 µM 0.200960035970487 0.426898897803012 no 1411 0.420364911605233 473 1893835 SGTC_2427 5545055 42.75 µM 0.200945827180829 0.426904533407787 no 1412 0.420370466787253 442 5372858 SGTC_2999 9069765 71.4286 µM 0.200817564271862 0.42695540675254 no 1413 0.420420614197454 468 2097066 SGTC_1743 st037606 46.3785 µM 0.198375633899787 0.427924188538957 no 1414 0.421375589967664 425 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3053 9095903 49.47 µM 0.198359245438035 0.427930691772948 no 1415 0.421382000640177 476 17174018 SGTC_1260 0700-1617 7.75 µM 0.196926094939803 0.428499466975367 no 1416 0.42194268635058 455 2853078 SGTC_657 3534-0529 86.7 µM 0.196746429671952 0.428570781328685 no 1417 0.422012987257892 455 1049549 SGTC_478 N-arachidonylglycine 10 µM 0.196248801486631 0.428768316551257 no 1418 0.422207716284058 462 5283389 SGTC_2314 7727897 200 µM 0.195987128485838 0.428872195712281 no 1419 0.422310120304261 430 900724 SGTC_780 0109-0199 192 µM 0.194469397078771 0.429474802906831 no 1420 0.422904177937784 472 610414 SGTC_874 0599-0792 117 µM 0.192376812183754 0.430305921903086 no 1421 0.423723527177516 479 765305 SGTC_2772 vinpocetine 57.06 µM 0.191555761169538 0.430632106073015 no 1422 0.424045099077024 478 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_176 1486-1328 72.834 µM 0.190810758674023 0.430928118928984 no 1423 0.424336929675915 426 22310231 SGTC_2889 9059656 51.95 µM 0.19073774719533 0.430957130769854 no 1424 0.42436553179274 436 3949838 SGTC_562 3772-2733 112 µM 0.190295021434629 0.431133060249967 no 1425 0.424538977346784 485 2876874 YIL048W NEO1 SGTC_2741 miltefosine 3.04 µM 0.188563007183132 0.431821455602882 no 1426 0.425217664305201 483 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1157 4092-0394 27.6 µM 0.187350833026837 0.43230336193215 no 1427 0.425692784757391 447 3659885 SGTC_755 1995-0008 37.3 µM 0.187246804769327 0.432344723626605 no 1428 0.425733564424892 460 689533 SGTC_307 1501-1223 22.3 µM 0.186274789381394 0.432731233269989 no 1429 0.426114638304737 470 2830329 SGTC_36 0335-0881 14.2 µM 0.185530048862192 0.433027413505466 no 1430 0.426406656890788 454 23828853 SGTC_773 4358-1457 44.6 µM 0.18451600182096 0.433430756296882 no 1431 0.426804337518526 471 1186886 SGTC_1550 gossypolone 36.6 µM 0.183941076017266 0.433659467028769 no 1432 0.427029840272504 447 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3210 9128157 49.47 µM 0.183241140767764 0.433937937637764 no 1433 0.427304407579545 427 17590849 SGTC_1522 st012842 45.6 µM 0.182001649626562 0.434431151978032 no 1434 0.42779071565457 494 3491067 YOR116C RPO31 SGTC_279 1273-0055 2.93 µM 0.180840481526739 0.434893292884632 no 1435 0.428246393632359 475 2847562 SGTC_367 0335-0881 7.1 µM 0.1799450809601 0.435249720011483 no 1436 0.428597841657824 474 23828853 SGTC_1786 berberine 21.6 µM 0.177671454849842 0.436155005492086 no 1437 0.429490502132757 475 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_205 1486-1330 71.903 µM 0.177495608911096 0.436225035741914 no 1438 0.429559557028158 461 4118834 SGTC_1436 4092-1007 8.32 µM 0.177002192046035 0.436421548567885 no 1439 0.429753333881289 449 2881121 SGTC_2969 9091408 28.7 µM 0.175883203301294 0.436867265591701 no 1440 0.430192850730408 436 4286311 SGTC_3123 9126162 49.47 µM 0.174835481139093 0.437284668291887 no 1441 0.430604453894135 464 25239884 SGTC_1866 st057638 64 µM 0.173244622484167 0.437918584818423 no 1442 0.431229575111499 466 688802 SGTC_3289 9119912 71.43 µM 0.172704425574696 0.438133875808457 no 1443 0.431441882481317 458 17014829 SGTC_1137 ixabepilone 100 µM 0.172639875474138 0.438159602940775 no 1444 0.431467253189971 461 154225 A novel microtubule stabilizer. SGTC_3223 9129970 49.47 µM 0.172451397220439 0.438234724458092 no 1445 0.431541334116862 454 17248386 SGTC_665 3914-0008 307 µM 0.172235847710095 0.438320638456761 no 1446 0.43162605828782 455 1069549 SGTC_92 0063-0024 660.874 µM 0.171419914436766 0.438645880476342 no 1447 0.431946798538695 482 3594437 SGTC_2262 9014885 67.46 µM 0.171400352951374 0.438653678458029 no 1448 0.431954488635346 486 6457424 SGTC_1711 st032263 62.8 µM 0.171349605018327 0.438673908702122 no 1449 0.431974439004835 465 3958979 SGTC_2369 9071472 200 µM 0.16917698188311 0.43954015654259 no 1450 0.432828717302206 454 17296037 SGTC_1899 st063254 59.6 µM 0.168923422627616 0.439641272250293 no 1451 0.432928437677682 479 3093813 SGTC_103 0844-0104 51.839 µM 0.168581793687204 0.439777515080769 no 1452 0.433062801057477 449 5375804 SGTC_2890 9046729 58.44 µM 0.168384716328678 0.439856113473856 no 1453 0.433140315517209 461 903329 SGTC_293 4049-0273 38.5 µM 0.167801828749303 0.440088594563285 no 1454 0.433369591883451 459 1380311 SGTC_1463 k081-0032 34.1 µM 0.167783670918364 0.440095837033527 no 1455 0.433376734550106 465 977755 SGTC_2115 tiliquinol 12.7705 µM 0.167489548957578 0.44021315392121 no 1456 0.433492435050686 472 71208 A bioactive hydroxyquinoline. SGTC_3079 9117512 49.47 µM 0.166718285376462 0.440520813937822 no 1457 0.433795858625938 497 7185044 SGTC_960 1222-0186 7.7 µM 0.166201346296656 0.44072704304192 no 1458 0.43399924999601 473 3126296 SGTC_2601 securinine 100 µM 0.165600811027196 0.440966642424153 no 1459 0.434235554499299 499 442872 A GABA receptor antagonist. SGTC_1539 benzyladenosine 56 µM 0.165012192768044 0.441201508173262 no 1460 0.43446719258764 434 92208 A nucleotide analog. SGTC_2897 9048598 12.99 µM 0.164068514165494 0.441578090380647 no 1461 0.434838603975901 454 6467404 SGTC_899 1083-0020 478 µM 0.163999759239548 0.44160552963126 no 1462 0.434865666671995 487 767123 SGTC_496 calpeptin 138 µM 0.163653904551378 0.441743560258096 no 1463 0.43500180351208 443 73364 A calpain inhibitor. SGTC_775 4577-0580 57.3 µM 0.162969737147917 0.442016632334398 no 1464 0.435271131171192 475 2006902 SGTC_1018 4259-0013 28.1 µM 0.162553709739433 0.442182695042567 no 1465 0.435434918189397 454 6801262 SGTC_970 1315-0089 19.5 µM 0.161899684371872 0.442443778238584 no 1466 0.435692425687325 474 6811083 YLR033W RSC58 SGTC_1870 st057514 26.5 µM 0.160225385870429 0.443112262303521 no 1467 0.436351766346436 479 5393161 SGTC_3344 9148862 3.898 µM 0.159917905151489 0.443235045383414 no 1468 0.436472871884368 470 4905352 SGTC_2869 9037858 32.47 µM 0.159409405106416 0.443438111376919 no 1469 0.436673164729052 486 27187042 SGTC_281 1672-3440 14.9 µM 0.15937401996144 0.443452242744472 no 1470 0.436687103172056 482 6833000 SGTC_87 0100-0052 35.5 µM 0.159329602205544 0.443469981466096 no 1471 0.436704599731596 488 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_527 4476-4215 268 µM 0.156698827774117 0.444520811137635 no 1472 0.437741105484313 463 4418754 SGTC_1548 st061468 90.8 µM 0.155972769096643 0.444810895117367 no 1473 0.438027242805317 492 390799 SGTC_464 bw-b 70c 158 µM 0.155750312773775 0.444899779553081 no 1474 0.43811491859785 488 5353454 SGTC_1134 3477-0009 42.5 µM 0.155538297011707 0.444984494946855 no 1475 0.438198482322599 482 3973534 SGTC_333 3486-0131 40.1 µM 0.155445684291728 0.445021501111836 no 1476 0.438234985491786 499 6744690 SGTC_518 1021-0119 62.6 µM 0.154854686123851 0.445257663267004 no 1477 0.438467938925892 460 1097762 SGTC_1771 st048882 4.1505 µM 0.154309422800721 0.445475567066881 no 1478 0.438682883991915 435 4580403 SGTC_956 1185-0240 191 µM 0.154133386930789 0.445545919872725 no 1479 0.438752281927841 459 1416193 SGTC_2118 5526350 200 µM 0.152984007103538 0.446005312030998 no 1480 0.439205443653283 470 743594 SGTC_2678 equilin 100 µM 0.152872740166403 0.446049787836025 no 1481 0.439249316696245 480 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3270 9137563 49.47 µM 0.152721387363143 0.446110287919677 no 1482 0.439308996970512 494 17015724 SGTC_3113 9123498 49.47 µM 0.152036953956366 0.446383891350583 no 1483 0.439578894696473 484 8897275 SGTC_3323 9138564 53.9225 µM 0.151732238293014 0.44650571018111 no 1484 0.439699064538007 446 43912313 YNL103W MET4 SGTC_140 0062-0056 502.533 µM 0.151223334725721 0.446709170236536 no 1485 0.439899771760111 457 3758964 SGTC_957 1187-1561 14.1 µM 0.150811483208336 0.446873839077533 no 1486 0.440062213793525 489 1538454 SGTC_2158 5657123 3.6195 µM 0.149437671864878 0.447423190306592 no 1487 0.440604143800283 487 2858827 SGTC_1606 st000094 49.2 µM 0.148651534022816 0.447737591718248 no 1488 0.440914303226504 480 1242210 SGTC_1128 3448-9350 235 µM 0.148267058617314 0.447891367574592 no 1489 0.441066005701525 425 619386 SGTC_467 ro 31-8220 72.8 µM 0.147748747414509 0.448098685161267 no 1490 0.441270529455614 479 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_542 3381-0244 89.3 µM 0.147409020045586 0.448234579284893 no 1491 0.441404593166116 495 1112843 SGTC_1201 1889-3372 45.9 µM 0.147017446126993 0.448391220048436 no 1492 0.441559124965872 469 5392199 SGTC_3275 9138069 49.47 µM 0.146116016574943 0.448751848186636 no 1493 0.44191490135911 484 17617007 SGTC_2188 6126565 140.678 µM 0.145877275580779 0.448847366604967 no 1494 0.442009135562785 475 874518 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.145397061310747 0.449039505580676 no 1495 0.442198692372151 494 5393153 SGTC_466 geldanamycin 89.2 µM 0.143671756792118 0.44972991705395 no 1496 0.442879837296152 484 5288382 HSP90 inhibitor. SGTC_2375 9072683 200 µM 0.142431859252936 0.450226178353057 no 1497 0.443369449432731 497 16798029 SGTC_2441 5730946 39.09 µM 0.141440150492007 0.450623159697282 no 1498 0.443761118782479 461 1774275 SGTC_3285 9112818 20.8695 µM 0.141374720768128 0.450649352978897 no 1499 0.443786961790561 495 17017947 YPR165W RHO1 SGTC_29 0299-0004 12.984 µM 0.139976378272012 0.451209198360656 no 1500 0.444339327014286 504 16871 A napthoquinone isolated from Swertia calycina. SGTC_1300 1094-0077 113 µM 0.138304448824932 0.451878705308382 no 1501 0.444999904823989 464 5532636 SGTC_1324 1418-0026 34.4 µM 0.137594121998318 0.452163189919676 no 1502 0.445280600653781 474 1372513 SGTC_1460 k062-0059 9.15 µM 0.134050649958308 0.453582708091174 no 1503 0.44668126147686 442 1373085 SGTC_91 0417-1751 58.384 µM 0.133558737542822 0.453779815964082 no 1504 0.446875757223024 508 6795624 SGTC_1143 3454-2408 5.08 µM 0.132885498801041 0.454049599212623 no 1505 0.447141967734206 485 X1143 SGTC_468 gf-109203x 121 µM 0.130940721512306 0.454829037742129 no 1506 0.447911100439002 495 2396 A protein kinase C inhibitor. SGTC_745 0469-0705 296 µM 0.12930004420524 0.455486732807636 no 1507 0.448560118228652 490 3486736 SGTC_3188 9110789 49.47 µM 0.129230565083751 0.455514587471151 no 1508 0.448587605773963 473 849217 SGTC_2288 7946289 167.31 µM 0.128115643157682 0.455961597250116 no 1509 0.449028728308073 484 1246052 SGTC_1407 3909-7909 12.3 µM 0.127279228288953 0.456296980792921 no 1510 0.449359700005357 498 4411780 SGTC_1385 3091-4834 14.1 µM 0.127168171521512 0.456341514404763 no 1511 0.449403648132961 472 4072814 SGTC_1045 1348-1485 165 µM 0.126864772257485 0.456463179888672 no 1512 0.449523714483618 468 6810614 SGTC_1704 st028805 70.8 µM 0.125835405988151 0.456875994183626 no 1513 0.449931107299761 472 2876101 SGTC_943 3253-1379 105 µM 0.125678829267923 0.456938791381843 no 1514 0.449993080383308 495 668464 SGTC_572 0960-0087 17.7 µM 0.124312686971063 0.457486746564175 no 1515 0.450533851235469 490 6796365 SGTC_1867 st057372 64 µM 0.123905609232448 0.457650039783758 no 1516 0.450695005825503 462 688837 SGTC_2748 diazoxide 86.69 µM 0.122390765300671 0.458257759627744 no 1517 0.451294775875604 500 3019 A potassium channel activatior. SGTC_2414 st077232 92.9 µM 0.122353812488085 0.458272585454247 no 1518 0.451309407946281 445 729801 SGTC_641 4092-0595 30 µM 0.122164862898503 0.458348394767498 no 1519 0.451384226660981 474 786260 SGTC_2925 9010536 32.5 µM 0.12108099467848 0.458783287591345 no 1520 0.451813441230755 476 2994177 SGTC_2919 7978188 46.38 µM 0.120676261109306 0.458945696142332 no 1521 0.451973731224476 489 2980291 SGTC_2210 7115885 190.385 µM 0.120318907181823 0.459089098231443 no 1522 0.452115263574331 502 2927039 SGTC_211 3455-0679 143.504 µM 0.117682336836323 0.460147287404793 no 1523 0.453159681340162 464 748649 SGTC_1106 tegaserod maleate 11.7 µM 0.117383567136107 0.460267216761577 no 1524 0.453278052783927 479 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2023 5144124 124 µM 0.116117511303514 0.460775465112851 no 1525 0.453779705339664 508 2830192 SGTC_894 0960-0238 55.9 µM 0.116110254439534 0.46077837851044 no 1526 0.453782580958869 509 6741907 YDL195W SEC31 SGTC_2311 7694451 200 µM 0.115862682790218 0.460877771828534 no 1527 0.453880685638307 507 2163142 SGTC_2721 ifenprodil 61.44 µM 0.115558177708593 0.461000025730317 no 1528 0.454001355063859 482 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2125 5246583 200 µM 0.115103900208645 0.461182417701502 no 1529 0.454181384267236 491 835267 SGTC_2909 7941780 10.49 µM 0.112445361679152 0.462249980804055 no 1530 0.45523514497261 490 1243215 SGTC_3271 9137798 49.47 µM 0.111699635171121 0.462549484025942 no 1531 0.455530784306036 507 6498326 SGTC_1939 st074455 53.6 µM 0.111287628033273 0.46271496595927 no 1532 0.45569413293078 516 1644229 SGTC_2062 5245942 200 µM 0.11051332393659 0.46302598125825 no 1533 0.456001141810253 489 1376160 SGTC_2664 lyso-paf C-16 73.48 µM 0.110304991858633 0.463109666024772 no 1534 0.456083749246955 482 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2193 5925765 200 µM 0.108738431633298 0.463738988542574 no 1535 0.456704979268579 481 877370 SGTC_3104 9120930 49.47 µM 0.108366446810925 0.463888436612719 no 1536 0.456852507963461 505 17014836 SGTC_1172 0370-0043 85 µM 0.107390505470021 0.464280553525382 no 1537 0.457239593242427 487 376585 SGTC_272 doxorubicin 8.13 µM 0.104239754168676 0.46554670761614 no 1538 0.458489543266414 480 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_838 0109-0203 71.4 µM 0.103633174279267 0.465790506938051 no 1539 0.458730230065411 502 759422 SGTC_266 formosanin C 406 nM 0.102715105032512 0.466159525858498 no 1540 0.459094542486963 498 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2139 5578692 56.4705 µM 0.101661235000085 0.466583165901855 no 1541 0.459512786331496 504 650991 YMR113W FOL3 SGTC_1264 0783-0040 158 µM 0.101039164829402 0.466833246638943 no 1542 0.459759685102913 493 2855798 SGTC_829 1635-0120 117 µM 0.0996826826721411 0.467378616336344 no 1543 0.460298124640994 502 285054 SGTC_2596 sinensetin 100 µM 0.0989185796471666 0.467685848760766 no 1544 0.460601458415286 493 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_351 caspofungin 25 nM 0.0973437442574985 0.468319122969554 no 1545 0.461226709017729 493 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2980 9014342 25.29 µM 0.0972810119754331 0.468344350601727 no 1546 0.461251617360485 502 2996599 SGTC_1485 3909-9022 254 µM 0.0965925223388426 0.468621233338709 no 1547 0.461524997517949 507 714516 SGTC_2359 9039622 200 µM 0.095579528096212 0.469028646284998 no 1548 0.461927262480797 506 6463596 SGTC_1056 3448-1962 115 µM 0.0955324945496699 0.469047563349312 no 1549 0.461945940681282 498 715507 SGTC_2057 5236571 38.335 µM 0.0948502696842647 0.469321964519662 no 1550 0.462216878695835 500 54684039 YBR257W POP4 SGTC_2202 7226349 200 µM 0.0934945486489617 0.469867299171004 no 1551 0.462755340137455 479 844334 SGTC_3083 9117465 49.47 µM 0.0925522260866608 0.470246378907517 no 1552 0.463129649412235 505 16420915 SGTC_789 1309-1135 70.6 µM 0.0914561997309135 0.470687324867216 no 1553 0.46356505393833 477 3092424 SGTC_1630 st005209 31.3 µM 0.0913198837022312 0.470742169140142 no 1554 0.463619209545085 512 3367314 SGTC_2247 cerulenin 830 nM 0.0911337886556484 0.470817041990564 no 1555 0.463693142439081 514 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3091 9116372 49.47 µM 0.0910855042842006 0.470836468729612 no 1556 0.463712325332586 468 17169793 SGTC_2649 anisomycin 9.56 µM 0.0903497095725122 0.471132517010728 no 1557 0.464004659558737 502 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2189 6047310 154.431 µM 0.0891069981975249 0.471632560233335 no 1558 0.464498437882146 525 711535 SGTC_2707 st078556 66.6 µM 0.0889505468441252 0.471695516443043 no 1559 0.464560606076575 513 17250899 SGTC_3026 9090633 49.47 µM 0.086383661505063 0.472728533984588 no 1560 0.465580717303535 494 25236842 SGTC_1677 st019204 53.9 µM 0.0863592507489335 0.472738358742846 no 1561 0.465590419529234 483 3945625 SGTC_3007 9078383 71.4286 µM 0.0860933259865036 0.472845388311685 no 1562 0.465696114509169 486 6496995 SGTC_525 k781-2675 26.7 µM 0.0857428606480816 0.472986446819069 no 1563 0.465835414847854 507 3651118 YDL195W SEC31 SGTC_2387 9077560 195.08 µM 0.0856582665971853 0.473020495517623 no 1564 0.465869039285616 485 5303272 SGTC_3233 9132340 49.47 µM 0.0856420864534849 0.473027007970095 no 1565 0.465875470595831 512 17682950 SGTC_845 0330-0138 4.51 µM 0.0852191673080805 0.473197234030861 no 1566 0.46604357635136 523 9039800 SGTC_622 1348-1566 26.3 µM 0.0846442733223902 0.473428638205069 no 1567 0.466272100161231 502 7340407 SGTC_2204 7233102 200 µM 0.0838097543524347 0.473764561590235 no 1568 0.466603846228293 507 2172480 SGTC_1645 Cervolide 78 µM 0.08347151641921 0.473900719641499 no 1569 0.466738312469985 499 23173 A fragrance. SGTC_1379 2144-0755 36.5 µM 0.0831831994855905 0.474016784347329 no 1570 0.466852935652908 516 5392327 SGTC_1033 k072-0102 21.3 µM 0.0831274090653261 0.474039243563135 no 1571 0.466875115991316 508 5965931 SGTC_1116 jasmonic acid  1.58368 µM 0.0829501442536287 0.474110604545404 no 1572 0.466945591021979 515 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2298 7976326 193.81 µM 0.0827892591225056 0.474175372326242 no 1573 0.467009554893152 516 2235818 SGTC_1252 0493-0875 34.8 µM 0.0822996560528112 0.474372476797878 no 1574 0.467204213962119 500 3960963 SGTC_1466 k213-0079 57.5 µM 0.0820654145967433 0.474466779977283 no 1575 0.467297347739578 509 3657981 SGTC_1644 st010134 20.9 µM 0.0813521932923486 0.474753924260662 no 1576 0.467580933629089 522 3818134 SGTC_2667 digitoxin 100 µM 0.0808228210454704 0.474967059043846 no 1577 0.467791429434887 518 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_798 1287-0182 476 µM 0.0802745102006631 0.475187826399296 no 1578 0.468009465344401 510 1649755 SGTC_389 tpck 16.7 µM 0.079584610172695 0.475465612870199 no 1579 0.468283817845492 477 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1359 1582-0056 520 nM 0.0794569944574145 0.475516998320611 no 1580 0.468334568433841 502 3661189 SGTC_97 0535-0701 19.132 µM 0.0787678977727672 0.475794475421278 no 1581 0.468608619276079 497 2832013 YGL099W LSG1 SGTC_1732 st034308 51.822 µM 0.0781213865733395 0.476054815390739 no 1582 0.468865747578048 480 830119 SGTC_1010 4112-3296 15.2 µM 0.0778207731687575 0.476175871205181 no 1583 0.468985310979586 511 704384 SGTC_2525 harmine 47.85 µM 0.0776778324893647 0.476233433616532 no 1584 0.469042163963351 514 5280953 A monoamine oxidase inhibitor SGTC_1397 3532-0190 20.1 µM 0.0763075064398043 0.476785290825976 no 1585 0.469587226991702 509 5322280 SGTC_1294 1000-1494 117 µM 0.0762086670984837 0.476825097103892 no 1586 0.469626543698405 497 712797 YDL207W GLE1 SGTC_2028 5153890 36.43 µM 0.0754956390922783 0.477112266821821 no 1587 0.469910183568432 502 2830968 YPR165W RHO1 SGTC_435 c-PAF 6.7 µM 0.0744341782477843 0.477539788708278 no 1588 0.470332456957155 523 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2464 5717415 7.67 µM 0.0743647524179732 0.477567752079277 no 1589 0.47036007730694 510 5285744 SGTC_795 0685-0265 78 µM 0.0743352970453532 0.477579616162601 no 1590 0.470371795865995 505 302754 SGTC_3106 9121286 49.47 µM 0.0739672715937059 0.477727851729719 no 1591 0.470518213691432 501 15943471 SGTC_589 1227-0070 34.1 µM 0.0738332074212328 0.477781851692893 no 1592 0.470571551713033 519 2841384 SGTC_251 melphalan 456.522 µM 0.0731265024081691 0.478066513469522 no 1593 0.470852726120194 511 460612 A DNA alkylator. SGTC_1336 1486-0901 104 µM 0.0728757901825084 0.478167503404453 no 1594 0.47095247967084 496 5006114 SGTC_2378 9074213 121.43 µM 0.0728673375959699 0.478170908233618 no 1595 0.470955842823508 519 657714 SGTC_826 1683-5028 118 µM 0.0726847133170591 0.478244472432406 no 1596 0.471028506688052 503 722377 SGTC_17 0960-0276 49.807 µM 0.070043692962761 0.47930840244163 no 1597 0.472079441529479 510 6821114 SGTC_417 st075190 100 µM 0.0697137209795105 0.479441341542497 no 1598 0.472210760295657 527 222757 SGTC_3145 9085516 49.47 µM 0.0695879335014997 0.479492019400031 no 1599 0.472260820664186 519 25236195 SGTC_2212 7123476 200 µM 0.069394585184757 0.479569917135812 no 1600 0.472337769463749 517 1085715 SGTC_2071 5230951 39.92 µM 0.0687084651398213 0.479846353013629 no 1601 0.472610839961603 521 1799272 SGTC_3078 9116413 49.47 µM 0.0678205737165354 0.48020409639364 no 1602 0.47296423300547 517 17177322 SGTC_3130 9127414 49.47 µM 0.0670895931666918 0.480498630255339 no 1603 0.473255189339864 524 1494646 SGTC_2406 ethylparaben 405.7 µM 0.0667991069841704 0.480615678765844 no 1604 0.473370817173307 468 8434 A possible steroid mimic. SGTC_854 0422-0053 192 µM 0.0666362207164628 0.480681312895079 no 1605 0.4734356549272 515 3596728 SGTC_116 0155-0182 31.788 µM 0.0652361379134556 0.481245490002575 no 1606 0.473992994251612 503 771486 SGTC_1861 st057647 17.4 µM 0.0631901403324695 0.482070012055837 no 1607 0.47480754798239 525 688668 SGTC_2088 5278280 127.392 µM 0.0618108236109076 0.4826259100999 no 1608 0.475356741987931 505 791502 SGTC_681 1642-0006 26.6 µM 0.0614322838339022 0.482778476750682 no 1609 0.475507471061639 528 4446530 SGTC_3043 9092303 49.47 µM 0.0609003743323271 0.482992861783133 no 1610 0.475719275663473 514 25236084 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0599964141217849 0.483357212336441 no 1611 0.47607924533179 521 2374 Ca(2+)-ATPase inhibitor. SGTC_516 3992-2719 87.3 µM 0.0595418325111151 0.483540441447867 no 1612 0.476260273517825 485 5350887 YDR037W KRS1 SGTC_857 0438-0306 1.35 µM 0.0582245779045092 0.484071409367043 no 1613 0.476784871795886 519 4686136 SGTC_2036 5160441 105 µM 0.0574130701675875 0.484398531529846 no 1614 0.477108075844186 506 134534 YIL048W NEO1 SGTC_939 1165-0479 45.3 µM 0.057263935165439 0.484458649621681 no 1615 0.47716747437928 515 1377347 SGTC_1526 st051518 75 µM 0.0564044069509295 0.48480514250373 no 1616 0.477509823153663 493 673993 SGTC_2788 5282734 71.43 µM 0.0558507798421465 0.485028326670506 no 1617 0.477730340789317 508 743706 SGTC_1695 st026914 34.495 µM 0.0557503330994354 0.485068820355967 no 1618 0.477770350903594 497 3289191 SGTC_863 0466-0191 129 µM 0.0553445180267411 0.485232420533549 no 1619 0.477931998117969 529 765160 YPR165W RHO1 SGTC_3354 9151612 71.43 µM 0.0545870579982152 0.485537789391248 no 1620 0.478233724803379 522 27261949 SGTC_1928 4'-methoxychalcone 40.3 µM 0.0526574273409869 0.486315754960259 no 1621 0.479002429997934 526 641818 SGTC_1400 3771-8998 51.5 µM 0.0526421007840363 0.486321934351846 no 1622 0.479008535940817 514 670767 SGTC_3074 9116018 49.47 µM 0.0514474426470913 0.486803608973719 no 1623 0.479484490518159 534 17027303 SGTC_2029 5175081 200 µM 0.0513154928153899 0.486856811064778 no 1624 0.479537061443983 524 1380876 SGTC_1908 st060353 56.5 µM 0.0512294473452217 0.486891504671537 no 1625 0.479571343528924 516 4227716 SGTC_1763 st044482 94.5 µM 0.0500175571120088 0.487380150261228 no 1626 0.480054198640269 532 88505 SGTC_124 0136-0217 7.121 µM 0.048055305069612 0.488171388674293 no 1627 0.480836083205465 518 3976905 SGTC_1111 tnp00062 510.699 nM 0.0470323000236501 0.488583913410856 no 1628 0.481243742154318 516 676306 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0468380708799196 0.488662237317234 no 1629 0.481321143071058 524 390807 SGTC_2142 5622915 118.518 µM 0.0456403340023804 0.489145240452448 no 1630 0.481798460383517 530 5322196 SGTC_48 0382-0018 55 µM 0.0454227251014175 0.489232995830965 no 1631 0.481885183833857 526 762596 SGTC_1621 st003705 32.4 µM 0.0453989205897599 0.489242595534014 no 1632 0.481894670673368 517 24207032 SGTC_3143 9086658 49.47 µM 0.0450887011048233 0.489367699064525 no 1633 0.482018303738249 513 25236626 SGTC_1271 0832-2808 169 µM 0.0445266148794559 0.489594376622483 no 1634 0.482242318702562 525 3663794 SGTC_891 0929-0073 133 µM 0.0439621707513937 0.489822008455103 no 1635 0.482467279032015 528 5603632 SGTC_3042 9091578 49.47 µM 0.0432494568798913 0.490109439973093 no 1636 0.482751340527978 531 25236497 SGTC_3085 9117376 49.47 µM 0.0430048772181564 0.490208078087621 no 1637 0.482848822997177 532 16480349 SGTC_1093 fluphenazine 7.97 µM 0.0427474253392159 0.490311908168763 no 1638 0.482951437072181 533 6602611 An atypical antipsychotic. SGTC_3197 9113331 49.47 µM 0.0427061099679582 0.490328570677319 no 1639 0.482967904482483 517 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2804 7954240 19.48 µM 0.0424981360981683 0.490412446892021 no 1640 0.483050798793932 525 828705 SGTC_423 5-fluorouracil 457 µM 0.0410547196316398 0.490994590683042 no 1641 0.483626136321993 532 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3107 9121808 49.47 µM 0.0408895905280406 0.491061190090256 no 1642 0.483691958031848 521 662681 SGTC_1241 0364-0022 50.8 µM 0.0390387370561584 0.491807687742698 no 1643 0.484429752217839 524 4563895 SGTC_972 1319-0219 195 µM 0.0356325405838359 0.493181569018397 no 1644 0.485787680578037 534 23903702 SGTC_499 genistein 192 µM 0.0353381082493858 0.493300331633902 no 1645 0.48590506815357 540 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_864 0469-0573 172 µM 0.0352091208319886 0.493352360356721 no 1646 0.485956494684858 517 689425 SGTC_636 0kpi-0074 126 µM 0.034688921442757 0.493562190565339 no 1647 0.486163897509999 534 616434 SGTC_2874 9043904 71.43 µM 0.0343583257724059 0.493695542205856 no 1648 0.48629570752571 510 4463428 SGTC_3226 9131256 49.47 µM 0.0329689600998802 0.494255975076346 no 1649 0.486849670215368 521 17178073 SGTC_3164 9100705 49.47 µM 0.0327698747077604 0.494336281741607 no 1650 0.486929050902588 532 17174235 SGTC_3206 9114350 49.47 µM 0.0321378357591486 0.494591233847564 no 1651 0.48718106520553 535 17087243 SGTC_10 0279-0212 42.575 µM 0.0321300285583199 0.494594383133163 no 1652 0.487184178220384 519 39851 YBR002C RER2 SGTC_2224 6650123 117.647 µM 0.0316654081073053 0.494781803337897 no 1653 0.487369440688004 530 2908370 SGTC_1701 st028638 40.4 µM 0.0311951330550969 0.494971505687985 no 1654 0.487556960643232 518 3490878 SGTC_2523 spermine 47.74 µM 0.0302264703833488 0.495362254138549 no 1655 0.487943218929992 524 1103 A DNA binding polyamine. SGTC_1967 st070177 51.4 µM 0.0290745377934011 0.495826937529966 no 1656 0.488402571554043 535 5729214 SGTC_1145 3546-0597 10.2 µM 0.0287137177927685 0.495972491565621 no 1657 0.488546457831378 532 875334 SGTC_1262 0737-0114 49.6 µM 0.0286352701108706 0.496004137268497 no 1658 0.488577741064881 536 765919 SGTC_300 r073-0011 5.04 µM 0.0282698653046639 0.496151541466926 no 1659 0.488723457496523 534 2735780 SGTC_2461 5755302 26.15 µM 0.0275301150773061 0.496449958092943 no 1660 0.489018460293599 532 2788904 SGTC_2100 5377183 190 µM 0.0269190127926548 0.496696479403761 no 1661 0.489262164498108 535 2844202 SGTC_3309 9129340 25.759 µM 0.0262533636013839 0.496965006605418 no 1662 0.489527626265381 534 17158987 SGTC_1821 st053465 65.6 µM 0.0261854400294795 0.496992407494292 no 1663 0.489554714537433 534 675086 SGTC_521 r062-0005 13.8 µM 0.025575104190685 0.497238622265021 no 1664 0.489798121775662 536 2832033 SGTC_556 4058-0063 51.5 µM 0.025044580726359 0.49745264088952 no 1665 0.490009702235027 537 6615692 SGTC_1807 st050092 58.9 µM 0.0236381751248217 0.498020002764704 no 1666 0.490570610652173 525 5008496 SGTC_76 0433-0009 400.328 µM 0.0225530204907835 0.498457770717834 no 1667 0.491003409251018 535 2841569 SGTC_166 k072-0058 166.424 µM 0.0220327546446833 0.498667654597306 no 1668 0.491210913723287 541 5846229 SGTC_2928 9011484 9.79 µM 0.0216986533931843 0.498802436786818 no 1669 0.491344168978748 537 2994751 SGTC_2729 fluphenazine 10.66 µM 0.0214574819495933 0.498899729579787 no 1670 0.491440360067671 541 3372 An atypical antipsychotic. SGTC_412 gemfibrozil 100 µM 0.0207156531496193 0.499198996722115 no 1671 0.49173624114593 540 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0199561739996148 0.499505384800156 no 1672 0.492039166838829 538 94937 An inhibitor of serotonin biosynthesis. SGTC_1046 2001-0062 216 µM 0.0199397309506567 0.49951201823718 no 1673 0.492045725361261 537 739778 SGTC_2621 lithochol-11-enic acid 100 µM 0.0196986543666921 0.499609273106443 no 1674 0.492141882116126 544 6708711 SGTC_740 k014-0057 261 µM 0.0196138982157453 0.499643465352101 no 1675 0.492175688396769 543 4012779 SGTC_2436 5633522 8.09 µM 0.019581054011874 0.499656715330249 no 1676 0.492188788822435 533 5724242 SGTC_18 0111-0177 500 nM 0.0189730970381839 0.499901976819561 no 1677 0.49243128349979 538 721752 SGTC_2352 9027995 87.8 µM 0.0188825563247046 0.499938502683211 no 1678 0.492467397548746 534 2997347 SGTC_3224 9130643 49.47 µM 0.0185776758760816 0.499938502683211 no 1679 0.492589005916671 531 17644395 SGTC_914 3820-6779 408 µM 0.0176157365871885 0.499550437976437 no 1680 0.492972701321902 543 2893481 SGTC_3178 9107506 49.47 µM 0.0173527087492067 0.499444327574615 no 1681 0.493077618209423 538 8897194 SGTC_3041 9091929 49.47 µM 0.017335533698944 0.499437398835968 no 1682 0.493084469032636 534 25236887 SGTC_2170 morpholine 200 µM 0.016787493739549 0.499216309298262 no 1683 0.493303073521373 541 121171 Reacts with secondary amines. SGTC_3201 9113999 49.47 µM 0.0160523790372387 0.498919750711386 no 1684 0.493596302318464 531 16649224 SGTC_2045 5106652 78.05 µM 0.015917116108044 0.498865183255746 no 1685 0.493650257526303 542 673349 SGTC_1427 4048-4900 550 nM 0.0156259426666418 0.498747718818026 no 1686 0.493766404476437 539 24132586 SGTC_875 0709-0210 25.7 µM 0.0150361034923278 0.498509767765086 no 1687 0.494001688606051 543 6251364 SGTC_3231 9132313 49.47 µM 0.0149274357482106 0.498465929422997 no 1688 0.494045035898677 538 4905967 SGTC_1049 3226-0134 66 µM 0.0141367755280341 0.498146964772895 no 1689 0.494360430377131 540 5702385 SGTC_2522 biochanin a 4.94 µM 0.0138173331196338 0.4980180970534 no 1690 0.494487857011936 539 5280373 A possible chelator. SGTC_2206 7254556 146.969 µM 0.0136917869757158 0.497967449966517 no 1691 0.494537937939276 540 4398905 SGTC_1720 st037298 9.481 µM 0.0134778802915907 0.497881157066164 no 1692 0.494623266485514 541 597396 SGTC_1204 4049-0315 18.3 µM 0.0133508810784437 0.497829923882345 no 1693 0.494673927282883 536 588402 SGTC_2832 7992762 51.95 µM 0.0129488357329569 0.497667733644341 no 1694 0.494834306301885 542 2985177 SGTC_2407 paclitaxel 400 µM 0.0121718922012888 0.497354305795736 no 1695 0.495144237469597 538 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2690 usnic acid 100 µM 0.0110919507518835 0.496918647898684 no 1696 0.495575042607892 542 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1963 st076565 50.3 µM 0.00961940758709959 0.49632461703295 no 1697 0.4961624707842 542 4914280 SGTC_2838 9002687 71.43 µM 0.00868639281695522 0.495948238603439 no 1698 0.496534674219643 536 6457060 SGTC_1817 st052116 64.4 µM 0.00780439087982245 0.495592442076191 no 1699 0.496886530111431 541 4361398 SGTC_114 0364-0001 490.298 µM 0.00653220627399126 0.495079253460583 no 1700 0.497394045265574 543 4003655 SGTC_1174 0739-0097 51.1 µM 0.00555622369320807 0.494685555736596 no 1701 0.497783398854429 543 728447 SGTC_3212 9128307 49.47 µM 0.00438436668512108 0.49421285188049 no 1702 0.498250896360264 543 27243542 SGTC_1471 k673-0312 37 µM 0.00403386710428266 0.494071468855457 no 1703 0.498390724222961 544 24099884 SGTC_628 1636-0253 16 µM 0.00393161047134208 0.494030221150814 no 1704 0.49843151839373 543 4456143 SGTC_2353 9059630 146.67 µM 0.00385871670829929 0.494000817714187 no 1705 0.498460598577172 542 4779114 SGTC_2686 alizarin 95.37 µM 0.00155016844330077 0.493069627457461 no 1706 0.499381572513906 547 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_322 k048-0136 19.3 µM 0.000237883562217835 0.492540312649304 no 1707 0.499905098190114 547 6823282 SGTC_2463 5473429 200 µM 0.000114751183145123 0.492490647422666 no 1708 0.499954220901418 548 5399405 SGTC_2702 st077768 96.8 µM 5.06835643914289e-05 0.492464805908304 no 1709 0.499979780183251 547 6484119 SGTC_763 3453-1109 128 µM -0.00172325144625379 0.491749306585659 no 1710 0.499312522478581 549 1560353 SGTC_1666 st014829 29 µM -0.00186438883875577 0.491692381309608 no 1711 0.499256216896003 550 3858230 SGTC_1074 carmofur 3.8 µM -0.00332318525560653 0.491104011647655 no 1712 0.498674243336111 551 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2834 9001755 58.44 µM -0.00335757925663278 0.491090139901639 no 1713 0.498660522191462 552 2989575 SGTC_2553 4-methylesculetin 85.09 µM -0.00377873482788761 0.490920280835732 no 1714 0.498492506498273 554 5319502 SGTC_2263 7948595 193.29 µM -0.0039395570831383 0.490855418970749 no 1715 0.49842834817885 555 2971371 SGTC_1808 st050063 61.5 µM -0.00440044287127994 0.490669538631298 no 1716 0.498244482951766 551 4011993 SGTC_2656 pseudo-anisatin 100 µM -0.00493674661219262 0.490453243950332 no 1717 0.498030531048579 549 6708809 A neurotoxin. SGTC_2808 7946468 45.46 µM -0.00607607223864193 0.489993756135682 no 1718 0.497576012800299 552 2970879 SGTC_3064 1327-0027 10 µM -0.00691644837636456 0.489654842545398 no 1719 0.497240758311565 549 16000455 YPR107C YTH1 SGTC_2973 9094665 17.96 µM -0.00707302290152357 0.489591698740442 no 1720 0.497178295641562 552 25237061 YIL048W NEO1 SGTC_2533 agelasine 13.65 µM -0.00710453252899399 0.48957899148273 no 1721 0.49716572543476 551 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1614 st002383 48.6 µM -0.00782437127888219 0.4892886965585 no 1722 0.496878559328836 549 1947235 SGTC_3147 9097027 49.47 µM -0.0085048093264186 0.489014296273586 no 1723 0.49660711287525 554 25236841 SGTC_2711 st079103 59.1 µM -0.00920890718683235 0.488730360170524 no 1724 0.496326229492008 550 54693780 SGTC_2597 laccaic acid a 100 µM -0.00926164806970265 0.48870909199041 no 1725 0.496305189821188 556 5491415 A textile dye. SGTC_2497 7-hydroxyflavone 100 µM -0.00998085779330661 0.488419068183901 no 1726 0.496018279939867 563 5281894 SGTC_2401 5128683 200 µM -0.0104502292207415 0.488229795826552 no 1727 0.495831037604279 559 708373 SGTC_555 4296-0685 37 µM -0.0120883675857211 0.487569243409232 no 1728 0.495177556518818 557 2908540 YHR072W ERG7 SGTC_260 nsc-65238 3.989 µM -0.0129755591045443 0.487211512105608 no 1729 0.494823646114676 553 3246252 SGTC_135 0933-0004 26.348 µM -0.0134342806910849 0.487026551470274 no 1730 0.494640658634927 556 21230617 YGL099W LSG1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0139743381711911 0.486808799056812 no 1731 0.494425227105726 551 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2885 9057732 51.95 µM -0.0140341635149089 0.486784677581917 no 1732 0.494401362586939 562 6471414 SGTC_791 1348-1292 225 µM -0.0140942865016421 0.486760436146584 no 1733 0.494377379357599 554 5437054 SGTC_1760 st045453 10.4495 µM -0.0145488224523092 0.486577169996626 no 1734 0.494196064345912 557 3323419 YIL048W NEO1 SGTC_2448 5185112 27.17 µM -0.0161266548471547 0.485941019751378 no 1735 0.49356667439266 553 5718189 SGTC_2593 nobiletin 86.24 µM -0.0167954250130276 0.485671395790723 no 1736 0.493299909847081 553 72344 An anti-infammatory. SGTC_678 1218-2179 85.9 µM -0.0175836858449578 0.485353605931921 no 1737 0.492985485737956 554 6820081 YOR116C RPO31 SGTC_2085 5307070 144.047 µM -0.0182063849423724 0.485102569378868 no 1738 0.49273710451707 561 2840351 SGTC_1565 sinapyl alcohol 95.1 µM -0.0184107909898416 0.485020165869193 no 1739 0.492655571968686 558 5280507 A phenol propionate derived from cinnamic acid. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0185444496349319 0.484966283555392 no 1740 0.49260225898596 555 688664 SGTC_1446 4239-0190 62 µM -0.0185669562070832 0.484957210423034 no 1741 0.492593281708376 555 1340085 SGTC_2035 5154463 94.595 µM -0.0197572509226004 0.484477375064135 no 1742 0.492118510021051 560 2769623 SGTC_470 aa-861 153 µM -0.0200085602275144 0.484376069315231 no 1743 0.492018271929644 553 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1972 st070201 17.4 µM -0.0207915455638767 0.484060445174116 no 1744 0.491705970972692 559 2829099 SGTC_3094 9117742 49.47 µM -0.0210832692472622 0.483942852875136 no 1745 0.491589615568055 561 17149698 SGTC_1175 0741-0056 27.6 µM -0.021208877831404 0.483892221137922 no 1746 0.491539516195473 558 765927 SGTC_1299 1079-1439 3.74 µM -0.0217176053397441 0.483687160130503 no 1747 0.49133661002723 559 323161 SGTC_2009 4012297 12.05 µM -0.0227422260261301 0.483274162885584 no 1748 0.490927946518854 565 45595307 SGTC_1447 4239-0816 81.9 µM -0.022976911710872 0.483179569861226 no 1749 0.490834344936232 558 1341554 SGTC_2443 5493264 126.67 µM -0.0229913044215789 0.483173768728457 no 1750 0.490828604591825 573 5340055 SGTC_67 0335-0847 266 µM -0.0238697781276135 0.48281969749233 no 1751 0.490478240485972 577 4552207 YOR254C SEC63 SGTC_345 1362-0200 395 µM -0.0250940709104739 0.482326265589672 no 1752 0.489989964711327 565 1419823 SGTC_1839 st053978 48 µM -0.0251329011707189 0.48231061610445 no 1753 0.489974478562985 563 3788398 SGTC_2589 lobaric acid 100 µM -0.0254340782416023 0.482189235766558 no 1754 0.489854364693799 558 73157 A novel microtubule depolymerizer. SGTC_2106 5357045 167.29 µM -0.0258737496156122 0.482012042442752 no 1755 0.489679018903705 566 668842 SGTC_3282 9108498 15.4605 µM -0.0260197657428996 0.481953196814784 no 1756 0.489620786502284 565 16459645 SGTC_1994 st072947 40.9 µM -0.0268627181961401 0.481613488187047 no 1757 0.489284614674275 574 5286565 YDL195W SEC31 SGTC_2782 7736369 71.43 µM -0.0270599933365468 0.481533988507543 no 1758 0.489205941879425 560 2950836 YOL077C BRX1 SGTC_2974 9094440 9.66 µM -0.027524322643606 0.481346871883832 no 1759 0.489020770264955 563 25236134 SGTC_154 3389-1638 511.116 µM -0.0291623756873089 0.480686798133433 no 1760 0.488367544157095 581 5238686 SGTC_52 0329-0193 875 nM -0.0303579877207553 0.480205044790576 no 1761 0.487890775170752 560 3739292 SGTC_3312 9133330 71.43 µM -0.0307411648786804 0.480050655576105 no 1762 0.487737980918795 571 17617324 SGTC_1007 4101-0031 70 µM -0.0314369810641834 0.47977030594132 no 1763 0.487460524546027 574 1146276 SGTC_355 1311-2252 105 µM -0.0318703264326681 0.47959571284348 no 1764 0.487287731344962 561 5338538 SGTC_2713 st079149 53.4 µM -0.0319321156232297 0.4795708185464 no 1765 0.487263093564355 560 3103253 SGTC_625 k213-0058 121 µM -0.0322627978672735 0.479437591065815 no 1766 0.487131238375614 558 3655420 SGTC_2251 lansoprazole 556 µM -0.0323295011057353 0.479410717495628 no 1767 0.48710464150799 573 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2887 9044784 58.44 µM -0.0325993260157747 0.479302010706621 no 1768 0.486997053653809 566 6465546 SGTC_55 0767-0285 6.563 µM -0.0327675498919514 0.479234237618807 no 1769 0.48692997787209 564 3116166 SGTC_2082 5219693 150 µM -0.0331483747282261 0.479080815274543 no 1770 0.486778133235683 567 2834649 SGTC_1443 4112-3303 14 µM -0.0336955935144751 0.478860363475777 no 1771 0.486559946422477 557 704433 SGTC_3242 9133940 49.47 µM -0.0342092859734291 0.478653423930177 no 1772 0.48635513087018 570 17248444 SGTC_1838 st055369 84.5 µM -0.0344365335374681 0.478561879728178 no 1773 0.486264525594005 559 676036 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.036179743950454 0.477859684401318 no 1774 0.485569518699888 571 1377 SGTC_3193 9111931 49.47 µM -0.0369555067907089 0.477547215670514 no 1775 0.485260240961977 571 17087244 SGTC_2051 5263410 176 µM -0.0383513565221411 0.476985017657022 no 1776 0.484703772147451 555 227584 SGTC_2565 isoliquiritigenin 100 µM -0.039101397567761 0.476682946976747 no 1777 0.48440477336247 564 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3221 9128209 49.47 µM -0.0391336882014642 0.476669942583124 no 1778 0.484391901115635 561 16460723 SGTC_358 0075-0058 9.45 µM -0.0392290396062429 0.47663154189618 no 1779 0.484353890596468 587 1069125 SGTC_934 2950-0684 338 µM -0.0396834196885026 0.476448553271071 no 1780 0.484172760218076 565 1121253 SGTC_2122 5258151 111.688 µM -0.0416817573888363 0.475643839197543 no 1781 0.483376198408124 575 2173356 SGTC_522 1273-0010 11.6 µM -0.0426767040478982 0.475243219238614 no 1782 0.482979625061713 557 5705015 SGTC_640 3381-0960 37.1 µM -0.0433997835664576 0.474952083545502 no 1783 0.482691425114581 578 1745025 SGTC_2635 hydroquinidine 100 µM -0.0462445394258766 0.473806822174463 no 1784 0.481557671549232 564 442912 An experimental heart treatment. SGTC_2691 st077356 60.2 µM -0.0463573176781598 0.473761423528552 no 1785 0.481512727736671 573 2839272 SGTC_1199 1638-0010 4.46 µM -0.0474177491046172 0.473334565856874 no 1786 0.48109014159567 568 3111136 SGTC_917 harmaline 728.087 nM -0.0479320224604157 0.473127565325635 no 1787 0.480885209239836 576 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_454 lyso-paf C-16 6.67 µM -0.0480962198774439 0.473061475633113 no 1788 0.480819779410927 584 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_111 0083-0039 52.457 µM -0.0484763397968884 0.472908479676548 no 1789 0.480668310187472 559 759313 SGTC_3060 1327-0027 12.5 µM -0.0494619473247847 0.472511797310808 no 1790 0.480275580848956 562 16000455 YPR107C YTH1 SGTC_2794 7785382 27.27 µM -0.0502009032577852 0.472214403900348 no 1791 0.479981145883829 571 2205081 SGTC_1276 0871-0068 94.2 µM -0.0511877098133617 0.471817286990177 no 1792 0.47958797257743 576 3414906 SGTC_448 monastrol 171 µM -0.0514890053414132 0.471696043310674 no 1793 0.479467931349077 571 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_609 0986-0026 86.3 µM -0.052303729673798 0.47136820502822 no 1794 0.479143340768441 578 2848610 SGTC_1540 guanosine 70.6 µM -0.0531731648998702 0.471018372942083 no 1795 0.478796968333094 571 6802 Guanosine is a purine nucleoside SGTC_3141 9094609 49.47 µM -0.0542246176558852 0.470595332899933 no 1796 0.478378103740588 587 25236309 YDL196W YDL196W SGTC_1133 3473-0247 50 µM -0.0560574437703169 0.469857995799406 no 1797 0.477648022774795 561 711311 SGTC_586 0957-0265 8.15 µM -0.0567050167638705 0.469597504886377 no 1798 0.47739008882428 575 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0569965682287091 0.469480230445437 no 1799 0.47727396442792 570 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_578 3460-0051 92 µM -0.0574331632411534 0.469304618254144 no 1800 0.477100073072707 571 2876744 SGTC_2968 9090663 33.37 µM -0.0581897191196738 0.46900032193756 no 1801 0.476798754900587 594 25236811 SGTC_203 k066-0004 30.888 µM -0.0589323042909621 0.468701662423502 no 1802 0.476503013826809 564 6795412 SGTC_428 3448-4153 16.5 µM -0.058981816697304 0.468681749707653 no 1803 0.476483295534066 583 3834874 SGTC_1212 0520-0165 585 µM -0.0593654176209644 0.468527477170335 no 1804 0.476330528600022 592 5403258 SGTC_2056 5235370 200 µM -0.0594117026706488 0.468508863060658 no 1805 0.476312096071207 584 5511916 SGTC_1506 4226-2149 212 µM -0.0597059778181169 0.468390518253888 no 1806 0.476194905310451 597 991114 SGTC_1339 1486-1321 22.7 µM -0.0604415601827542 0.468094710906292 no 1807 0.475901979452109 578 3469382 SGTC_2355 9061122 103.12 µM -0.0607921502260569 0.467953730693162 no 1808 0.47576237098611 580 5302957 SGTC_3232 9132874 49.47 µM -0.0609405912205717 0.467894040410463 no 1809 0.475703261191254 577 3784940 SGTC_3334 9142812 21.919 µM -0.0623150980929598 0.467341365669996 no 1810 0.475155952652148 583 45283678 SGTC_2114 5491910 81.25 µM -0.0625029082610947 0.467265854043755 no 1811 0.475081173006404 578 2849228 SGTC_1100 amiodarone 5.07 µM -0.062656952501397 0.467203919346176 no 1812 0.475019838464248 573 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3171 9103192 49.47 µM -0.0632907077010274 0.46694912145622 no 1813 0.474767507555035 573 13018434 SGTC_1473 k844-0725 134 µM -0.0640928943995081 0.466626626016369 no 1814 0.474448129831307 565 54682906 SGTC_3008 9078912 71.4286 µM -0.0644256436844407 0.466492860423255 no 1815 0.47431565586523 582 16648731 SGTC_2689 tacrolimus 100 µM -0.0646007968775693 0.466422450158798 no 1816 0.474245925110274 574 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1155 4088-0394 48.2 µM -0.0648450078035067 0.466324280960389 no 1817 0.47414870289479 574 2326248 SGTC_2841 9004761 38.96 µM -0.0663726788415354 0.465710226416096 no 1818 0.473540560675991 576 2991039 SGTC_53 0973-0023 39.979 µM -0.0683095202020619 0.464931821478965 no 1819 0.472769622903764 590 674768 SGTC_1403 3909-7815 62.9 µM -0.0696898052206415 0.464377174908916 no 1820 0.472220278154456 580 6615483 SGTC_2975 9084847 53.72 µM -0.0700135814569761 0.464247080328687 no 1821 0.472091424863016 574 27211724 SGTC_1892 st058411 7.36 µM -0.0702984414097456 0.464132625626408 no 1822 0.471978061507421 586 3934738 SGTC_1360 1598-0022 39.8 µM -0.0706931480058463 0.463974040232021 no 1823 0.471820987147073 600 761525 SGTC_985 1493-0307 8.71 µM -0.0714766277328641 0.463659270374442 no 1824 0.471509212669775 585 3278274 SGTC_2856 9022925 19.48 µM -0.0718986424326579 0.463489731678312 no 1825 0.471341285218587 583 4944862 SGTC_1942 st076330 65.2 µM -0.0721891879015944 0.463373012819035 no 1826 0.471225674764659 622 24208414 SGTC_782 0083-0095 30.5 µM -0.072701402345053 0.463167252071821 no 1827 0.47102186629721 623 3591729 An indicator and reagent. SGTC_750 4073-0104 132 µM -0.0733010370973047 0.462926386392444 no 1828 0.470783283218886 588 22330957 SGTC_1462 k081-0014 26.5 µM -0.0744359146301032 0.462470557748928 no 1829 0.470331766157201 588 3270634 SGTC_296 1222-0039 74.9 µM -0.0752564062764771 0.462141034264374 no 1830 0.470005352914465 595 5984176 SGTC_5 0352-0601 109.883 µM -0.0763529459477005 0.461700685776365 no 1831 0.469569151982818 592 762456 SGTC_1529 apigenin 74 µM -0.0766127256214927 0.46159637029272 no 1832 0.46946581756382 593 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3038 9091290 49.47 µM -0.0777660774691608 0.461133269617418 no 1833 0.469007065479887 584 25236843 SGTC_2457 5731572 11.68 µM -0.0782377416834788 0.460943899351694 no 1834 0.468819470245968 582 2865357 SGTC_1210 3013-0140 750 nM -0.0789821527350822 0.460645040953029 no 1835 0.468523409382524 586 905973 SGTC_485 niflumic acid 177 µM -0.0794897176945454 0.460441281792244 no 1836 0.468321554912752 598 4488 A COX2 inhibitor. SGTC_1682 st012968 530 nM -0.0806153472726578 0.459989441127733 no 1837 0.467873930286457 587 24207270 SGTC_2878 9043973 25.97 µM -0.0809055596074697 0.459872954911368 no 1838 0.467758529267714 591 6465167 SGTC_2404 5161160 200 µM -0.0810668480317482 0.459808218013258 no 1839 0.46769439516151 591 2831543 SGTC_1190 1486-1332 13 µM -0.081334228122923 0.459700901080474 no 1840 0.467588077022701 586 4150046 SGTC_227 fluconazole 33.516 µM -0.0815075865191042 0.459631322706481 no 1841 0.467519145892764 594 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3156 9099931 49.47 µM -0.0831425117022287 0.458975197329825 no 1842 0.466869111695912 584 18111053 SGTC_500 h-89 112 µM -0.0831921829399386 0.458955265093667 no 1843 0.466849364152284 598 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2643 anethole 100 µM -0.0841296577391977 0.458579091558252 no 1844 0.466476672379231 595 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2563 tomatine 8.54 µM -0.0847718409369746 0.458321428871867 no 1845 0.466221390306091 587 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_918 glabranin 770.725 nM -0.0855648708828937 0.458003266234111 no 1846 0.465906162490948 596 124049 Also referred to as licorice root. SGTC_1086 cerivastatin 2.18 µM -0.0870164012921139 0.457420983865173 no 1847 0.465329237605884 580 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_931 2812-0076 566 µM -0.087156778377776 0.457364676332411 no 1848 0.465273447212128 595 3450959 SGTC_3330 9141424 71.43 µM -0.088810078363874 0.456701575512048 no 1849 0.464616423983735 583 27261020 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0891362210149643 0.456570781329849 no 1850 0.464486825871541 621 689007 SGTC_2826 7992541 19.48 µM -0.0893997447621003 0.456465102872203 no 1851 0.464382113155421 596 2985066 SGTC_3175 9106517 49.47 µM -0.0894870088721127 0.456430108842601 no 1852 0.464347438789662 595 41468073 SGTC_2786 7743617 45.45 µM -0.090919870117749 0.455855561594357 no 1853 0.463778130756218 601 583674 SGTC_70 0141-0289 43.283 µM -0.0913029103276313 0.455701986105309 no 1854 0.463625952771436 584 352408 SGTC_456 gingerol 170 µM -0.0918013177884085 0.455502165379819 no 1855 0.463427948520754 624 442793 A herb. SGTC_718 1130-0073 349 µM -0.092106586022958 0.455379783280616 no 1856 0.463306677904544 610 6740020 SGTC_1888 azatryptophan 97.5 µM -0.0922712196673717 0.45531378337486 no 1857 0.463241277088431 594 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_879 0831-1030 162 µM -0.0925160348115098 0.455215641825816 no 1858 0.463144025960064 590 1549252 SGTC_2233 sulbentine 40.3845 µM -0.0926987856319292 0.455142382417879 no 1859 0.463071430891957 597 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_602 3130-1533 38.1 µM -0.0931193581391635 0.454973793116754 no 1860 0.462904369341985 584 720941 SGTC_2725 haloperidol 53.21 µM -0.0931914487552879 0.454944895924658 no 1861 0.462875733865463 590 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2625 euphol 100 µM -0.094522858916476 0.454411249302685 no 1862 0.46234691247323 577 6708538 A triterpene alcohol. SGTC_3033 9090887 49.47 µM -0.0947441682995598 0.454322553553782 no 1863 0.462259017258804 580 19325384 SGTC_2943 9068529 45.32 µM -0.0951482140079034 0.454160627135252 no 1864 0.462098551258909 573 3270634 SGTC_2679 rapamycin 1 nM -0.0967148141303498 0.453532864636061 no 1865 0.461476437504528 601 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_849 0386-0493 241 µM -0.0967563533440703 0.453516220761216 no 1866 0.461459943112102 593 726119 SGTC_1246 0422-0085 105 µM -0.0984083375682192 0.452854372493895 no 1867 0.460804027197621 601 264295 SGTC_1089 terbinafine 2.25 µM -0.0986829500873912 0.45274436482625 no 1868 0.460695003319388 599 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1794 st048918 76.9 µM -0.0999553984424505 0.452234679252289 no 1869 0.460189867464339 589 672303 SGTC_2623 humulene 100 µM -0.100266219493512 0.452110190249346 no 1870 0.460066487624726 606 6187145 An anti-inflammatory. SGTC_2484 5809818 12.04 µM -0.100545654810201 0.451998275774043 no 1871 0.459955569576075 599 2870548 SGTC_2012 4023501 200 µM -0.100731234108747 0.451923952953091 no 1872 0.459881908118902 598 3477460 SGTC_2762 leflunomide 42.06 µM -0.101941828043323 0.451439162555261 no 1873 0.459401424453286 594 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_289 k017-0060 526 µM -0.10302951566489 0.451003652546723 no 1874 0.45896977274372 603 5512909 SGTC_2166 5933061 31.504 µM -0.103053729095199 0.450993958160913 no 1875 0.458960164128359 585 2877375 SGTC_131 0141-0277 33.849 µM -0.103253274889967 0.450914066673779 no 1876 0.458880979285666 613 1547771 SGTC_1725 st036284 20.55 µM -0.10564426507372 0.44995694944859 no 1877 0.457932301395839 609 707914 SGTC_2013 4024628 200 µM -0.106001994879285 0.449813774523028 no 1878 0.457790384710494 606 5230760 SGTC_1076 itraconazole 331 nM -0.106234541651035 0.449720705359365 no 1879 0.457698132864384 598 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1361 1608-0041 5.61 µM -0.107913286884343 0.449048925390023 no 1880 0.457032238632088 588 X1361 SGTC_1896 st058441 89 µM -0.109057738941422 0.448591035998293 no 1881 0.456578347165862 590 688759 SGTC_104 0074-0074 590.992 µM -0.109717455040337 0.448327118047049 no 1882 0.456316728435829 622 3943124 SGTC_512 prima-1 270 µM -0.110340858070514 0.448077748070308 no 1883 0.45606952750991 591 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1954 st077032 68.9 µM -0.110486047652036 0.448019673138492 no 1884 0.456011957242257 649 698907 SGTC_684 1140-0066 328 µM -0.110494429664434 0.448016320419542 no 1885 0.456008633652507 612 6813534 SGTC_2086 5274770 176.623 µM -0.112255413965052 0.447312027478393 no 1886 0.455310446393612 601 689278 SGTC_930 2810-3379 265 µM -0.112989646827919 0.447018425291969 no 1887 0.455019381641692 643 1015764 SGTC_325 2810-4341 181 µM -0.11303098167295 0.447001897336425 no 1888 0.455002996389876 594 774970 SGTC_2914 7968218 45.32 µM -0.113285930787527 0.446899956625692 no 1889 0.454901935518662 611 2977111 SGTC_2638 epoxomicin 18 µM -0.113636165176579 0.446759922078561 no 1890 0.45476310868293 610 9915668 A protesome inhibitor. SGTC_1295 1013-0063 9.78 µM -0.114422256119591 0.446445642789447 no 1891 0.454451536013333 601 6826038 SGTC_2652 actinonin 100 µM -0.116011782711421 0.445810252770172 no 1892 0.453821601799132 593 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3346 9158254 43.5805 µM -0.117096542254835 0.445376715780786 no 1893 0.453391774884099 593 17639500 SGTC_2348 9022543 33.42 µM -0.117601809850222 0.445174801871824 no 1894 0.45319158542322 613 3162678 YDL140C RPO21 SGTC_366 0181-0206 4.31 µM -0.118601356271094 0.444775407307594 no 1895 0.452795595394577 618 274874 SGTC_1319 1306-0155 43.7 µM -0.119132045600721 0.444563379449341 no 1896 0.452585371402263 595 3122360 SGTC_1148 3909-7663 27.7 µM -0.120598174763604 0.443977695207757 no 1897 0.452004657309643 642 4084526 SGTC_3191 9110352 49.47 µM -0.120832306642652 0.443884176303522 no 1898 0.45191193028833 595 17122424 SGTC_2017 5132927 60.65 µM -0.122107446440449 0.443374904335307 no 1899 0.451406962303189 616 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_317 4495-0002 170 µM -0.12356676064893 0.442792190631602 no 1900 0.450829155948223 613 15991618 SGTC_1365 1672-3266 55.4 µM -0.124357274604993 0.442476584824462 no 1901 0.450516200306278 603 6415873 SGTC_1640 st009078 66.4 µM -0.125681369643969 0.441948033295604 no 1902 0.449992074892445 611 690618 SGTC_2873 9040596 71.43 µM -0.126037549232703 0.441805871322467 no 1903 0.449851100786714 597 6463863 SGTC_1119 parthenolide 318.541 nM -0.126482834323658 0.441628155211771 no 1904 0.449674868070734 654 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1482 3346-2049 8.48 µM -0.126839654978624 0.441485754298761 no 1905 0.449533654530477 615 3826804 SGTC_3005 9076496 71.4286 µM -0.127013957604963 0.441416195902861 no 1906 0.4494646757258 608 21368410 SGTC_408 cantharidin 100 µM -0.129890030506388 0.440268713078384 no 1907 0.448326715984718 595 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2935 9038016 29.96 µM -0.131012295066288 0.439821092421995 no 1908 0.447882790592086 608 6463195 SGTC_980 1473-0395 201 µM -0.131238233396369 0.439730985107399 no 1909 0.447793425813096 591 768876 SGTC_1278 0874-0585 172 µM -0.132649505450301 0.439168221231834 no 1910 0.447235289324612 604 766306 SGTC_2282 7944268 200 µM -0.133161035662476 0.438964271915233 no 1911 0.447033012697828 624 2970414 SGTC_1464 k208-0027 110 µM -0.134317532787561 0.438503231300474 no 1912 0.446575744854436 597 X1464 SGTC_492 tmb-8 126 µM -0.134689483716168 0.438354969789791 no 1913 0.446428694099701 628 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3014 9081533 49.47 µM -0.135612264431339 0.437987182154991 no 1914 0.446063904707093 635 21367265 SGTC_382 3229-0966 23.2 µM -0.136213412099679 0.437747614826489 no 1915 0.445826286334326 632 5722370 SGTC_1957 st077035 62.4 µM -0.137284851233743 0.43732068516925 no 1916 0.445402822011792 609 705593 SGTC_360 0957-0399 1.01 µM -0.139213735192514 0.436552279089718 no 1917 0.444640627539479 636 6752301 YPR165W RHO1 SGTC_2646 retinol 96.75 µM -0.139918898104925 0.436271424185568 no 1918 0.444362034820786 628 445354 A vitamin A analog and teratogen. SGTC_1370 2001-0092 44.6 µM -0.140158606830804 0.436175959413694 no 1919 0.444267337985392 597 790957 SGTC_2866 9034245 58.44 µM -0.140255176233453 0.436137501388474 no 1920 0.444229189180584 628 6462273 SGTC_1395 3486-0190 4.35 µM -0.140290086290831 0.436123598873978 no 1921 0.444215398428538 633 6748079 SGTC_158 k038-0087 26.446 µM -0.141943350197541 0.435465296884024 no 1922 0.443562376226111 598 X158 SGTC_2512 diallyl trisulfide 49.23 µM -0.142489155953063 0.435248005344637 no 1923 0.443346822135913 605 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_638 3970-0837 4.09 µM -0.144450240777613 0.434467436737234 no 1924 0.442572473184432 613 4118451 YLR208W SEC13 SGTC_2216 7189485 200 µM -0.144919929283318 0.434280524892286 no 1925 0.442387045624729 618 731273 SGTC_597 k018-0003 82.8 µM -0.14538830857323 0.434094148676995 no 1926 0.442202147496547 638 6786234 SGTC_2872 9044037 25.97 µM -0.146508638142585 0.433648409680541 no 1927 0.441759935624154 596 6465195 SGTC_2718 lomofungin 53.02 µM -0.147234372253159 0.433359711073779 no 1928 0.44147351554693 627 5351222 A RNA synthesis inhibitor. SGTC_1909 st060837 51.5 µM -0.150858863896648 0.431918415632255 no 1929 0.440043525439172 639 678937 SGTC_1164 k060-0068 93.7 µM -0.153487614550413 0.430873646618264 no 1930 0.439006878368042 606 5963676 SGTC_856 0433-0016 11.3 µM -0.153840700413298 0.430733353072893 no 1931 0.438867670761644 623 3911780 SGTC_2225 6654152 15.4 µM -0.155818679444074 0.429947593932 no 1932 0.438087973200674 640 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2123 5259487 200 µM -0.156235919868187 0.429781879025172 no 1933 0.43792353220567 608 2173474 SGTC_180 1486-1293 102.781 µM -0.156484075569406 0.429683325170978 no 1934 0.437825735233563 645 4140536 SGTC_559 1550-0661 158 µM -0.157422557743925 0.429310651118104 no 1935 0.437455918295409 632 5830875 SGTC_2335 9018011 154.17 µM -0.157679714309699 0.429208544465509 no 1936 0.437354593070861 633 6458208 SGTC_1950 st077106 7.18 µM -0.158017992733947 0.429074234761267 no 1937 0.437221310345228 593 13831864 SGTC_551 k048-0028 34.9 µM -0.160269910688221 0.42818034567061 no 1938 0.436334230124806 642 6836383 SGTC_2274 7947094 46.08 µM -0.161296277826573 0.427773055615211 no 1939 0.435930027370682 620 2971028 SGTC_2592 piperlongumine 83.33 µM -0.161796160387091 0.427574716623437 no 1940 0.435733188385966 633 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1191 1487-1166 10.6 µM -0.163070203907903 0.427069295755152 no 1941 0.435231579789166 616 3955771 SGTC_1332 1480-0653 17.5 µM -0.163600577579277 0.426858928509987 no 1942 0.435022794994912 604 5749438 SGTC_1404 3909-7820 48.3 µM -0.164051630058323 0.426680039562647 no 1943 0.434845249718165 622 23741373 SGTC_2218 6965428 192.983 µM -0.164696794246265 0.426424191472323 no 1944 0.434591320172705 615 675684 SGTC_349 k015-0014 24 µM -0.165543788197662 0.426088352231794 no 1945 0.434257993624124 624 2196908 SGTC_2067 5224629 34.075 µM -0.170642918326109 0.424067651173232 no 1946 0.432252274446643 634 2835000 SGTC_1658 st012944 20 µM -0.172676711521044 0.423262245974496 no 1947 0.43145277515133 660 24207260 SGTC_2537 larixol 68.93 µM -0.172692111375861 0.423256148675746 no 1948 0.431446722420205 620 6708759 SGTC_3246 9135460 32.98 µM -0.17348845832838 0.422940874338939 no 1949 0.431133749622433 610 41446951 SGTC_2134 5324836 1.464 µM -0.175323440714787 0.422214591657931 no 1950 0.430412746999705 601 699272 SGTC_1827 berberine 7.24 µM -0.178497771509603 0.420958823024015 no 1951 0.429166035585761 626 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_663 1486-0733 13.9 µM -0.179261755953686 0.420656709487024 no 1952 0.428866087357852 630 722445 YPR165W RHO1 SGTC_2848 9016370 25.97 µM -0.17979554899988 0.420445651618318 no 1953 0.428656539029572 610 7894410 SGTC_1183 1254-0324 198 µM -0.179808881876281 0.420440380188949 no 1954 0.428651305269601 629 5799357 SGTC_1676 st018489 23.4 µM -0.180803725920593 0.4200470882683 no 1955 0.428260819225238 613 3696235 SGTC_928 2764-0428 58.7 µM -0.182063821042986 0.419549049214325 no 1956 0.427766320394369 629 662578 SGTC_2641 levomentholum 100 µM -0.18237898610379 0.419424503723299 no 1957 0.427642657947999 621 16666 SGTC_1822 st052468 42 µM -0.182930543675933 0.419206561149434 no 1958 0.427426258434646 625 2873678 SGTC_3256 9138902 49.47 µM -0.183449556635237 0.41900150089573 no 1959 0.427222647495607 633 17228773 SGTC_2110 5483698 200 µM -0.184213690545395 0.418699634247122 no 1960 0.426922909885413 621 2848765 YHR062C RPP1 SGTC_142 0335-0849 62.6745 µM -0.184227642037046 0.418694123236051 no 1961 0.426917437693394 615 3889043 YPR107C YTH1 SGTC_2240 6690706 185.951 µM -0.184287436631768 0.418670503815291 no 1962 0.426893984625489 607 805876 SGTC_3120 9124077 49.47 µM -0.184362275793116 0.418640942063999 no 1963 0.42686463103314 636 18774327 YGL155W CDC43 SGTC_1801 st050089 28.441 µM -0.184509009995653 0.418582982833675 no 1964 0.426807079773836 634 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3173 9105693 49.47 µM -0.18539449534796 0.418233258383408 no 1965 0.426459812829857 658 17096658 SGTC_487 nimodipine 119 µM -0.185702824119841 0.418111498392227 no 1966 0.426338906759603 628 4497 L-type voltage-gated calcium channels inhibitor SGTC_406 estrone 100 µM -0.18573775397891 0.418097704976898 no 1967 0.426325210024675 630 5870 A steroid. SGTC_1749 st037932 54.2 µM -0.186902258831519 0.417637912642053 no 1968 0.425868634058463 652 594497 SGTC_898 1000-0849 28.3 µM -0.187390405560046 0.417445206556949 no 1969 0.425677272308373 628 6751807 SGTC_380 3970-0968 6 µM -0.18791637642043 0.417237590799516 no 1970 0.425471102452772 621 2891601 SGTC_2982 9019404 25.97 µM -0.189067778813951 0.416783179929194 no 1971 0.425019847388256 623 22333232 SGTC_832 4083-0019 164 µM -0.189213142664704 0.416725818724427 no 1972 0.424962883682501 622 1990758 SGTC_1579 chlormadinone acetate 49.4 µM -0.190067555045716 0.416388699776318 no 1973 0.424628096964797 661 45114258 A steroidal progestin. SGTC_1131 3454-3128 32.3 µM -0.191102241128459 0.415980533961574 no 1974 0.424222745915473 609 710982 SGTC_1158 4092-0494 91.8 µM -0.191552690899201 0.415802867579906 no 1975 0.424046301670641 662 1148199 SGTC_32 0928-0142 34.1 µM -0.191710914181878 0.415740465240635 no 1976 0.423984328143711 637 2244242 SGTC_2830 7992007 71.43 µM -0.191817519052041 0.415698422099915 no 1977 0.423942573782501 604 1952075 SGTC_2481 5478948 45.16 µM -0.192103080565077 0.415585806270281 no 1978 0.423830730956291 631 77792 SGTC_2752 diclazuril 33.15 µM -0.193318488899498 0.415106567874102 no 1979 0.423354773695818 645 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_673 1082-0474 110 µM -0.193462652532246 0.415049732175239 no 1980 0.423298326224049 648 3098046 SGTC_1180 1193-0155 285 µM -0.194206567493017 0.414756476181461 no 1981 0.423007070329099 653 2921347 SGTC_901 1112-0062 60.1 µM -0.194335148698125 0.41470579346522 no 1982 0.422956732768296 624 1908457 SGTC_1135 dihydrocapsaicin 536.708 nM -0.195082826300651 0.414411110341313 no 1983 0.422664053453207 661 107982 A Capsaicinoid. SGTC_2227 7312221 64.1025 µM -0.196295018888154 0.413933449759726 no 1984 0.422189629951986 620 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1824 st053723 68.6 µM -0.196566909927577 0.413826329425961 no 1985 0.422083233705635 662 675225 SGTC_1040 k898-0338 155 µM -0.196876377281328 0.413704412481606 no 1986 0.421962140037084 636 20969351 SGTC_1472 k841-0093 193 µM -0.197927709752716 0.413290294504395 no 1987 0.421550811893782 655 X1472 SGTC_2432 5630864 12.22 µM -0.198046594049439 0.413243472254208 no 1988 0.4215043044336 658 5714970 SGTC_387 norethindrone acetate 66.7 µM -0.199205822457782 0.412786978137519 no 1989 0.421050872518922 660 541197 SGTC_2112 5488546 200 µM -0.199626712081097 0.412621264592643 no 1990 0.420886267520019 659 600757 SGTC_810 3825-7150 143 µM -0.199729130568694 0.41258094252568 no 1991 0.420846214940877 634 22330411 YGL099W LSG1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.20222890830795 0.411597069305439 no 1992 0.419868887215385 634 5106787 A p450 inhibitor. SGTC_1205 4161-2785 76 µM -0.203364229094328 0.411150407985958 no 1993 0.419425178317368 683 3498106 SGTC_348 k064-0012 10.7 µM -0.203675033534361 0.411028150421423 no 1994 0.419303726788117 635 5066323 SGTC_2724 maprotiline 69.64 µM -0.204919918139056 0.410538551233885 no 1995 0.418817346505128 615 4011 A tricyclic antidepressant. SGTC_2541 muurolladie-3-one 83.07 µM -0.208430322605153 0.409158701446893 no 1996 0.417446491089543 661 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2824 7998404 51.95 µM -0.208889376763486 0.408978341856093 no 1997 0.417267298671956 619 837851 SGTC_1810 st050138 53 µM -0.208907549273787 0.408971202383441 no 1998 0.417260205361064 664 3444541 SGTC_535 2293-4129 48.2 µM -0.209187150972667 0.408861358479573 no 1999 0.417151071288179 676 396118 YIL048W NEO1 SGTC_222 nsc-310342 10.666 µM -0.209615207774493 0.408693206596732 no 2000 0.416984004621596 638 432556 SGTC_969 1313-0238 134 µM -0.211962327964597 0.40777149604158 no 2001 0.416068212223125 637 5212874 SGTC_1249 0481-0015 10.2 µM -0.213190191023698 0.407289519024629 no 2002 0.415589309419869 638 4227577 SGTC_379 3970-0972 5.9 µM -0.214090718640205 0.406936121196788 no 2003 0.415238156729316 636 2898042 YBL034C STU1 SGTC_1020 4335-0961 93.3 µM -0.214340596411658 0.406838074030701 no 2004 0.415140731113272 676 669075 SGTC_1999 st074831 12.5 µM -0.214697767351828 0.406697937256215 no 2005 0.41500148169333 691 17112523 SGTC_2825 7998094 58.44 µM -0.21545960784899 0.406399067464441 no 2006 0.414704500375093 668 2987815 SGTC_2469 5655019 90.81 µM -0.215879918366157 0.406234203105043 no 2007 0.414540675421588 659 2788239 SGTC_1561 5-methoxyflavone 52.9 µM -0.216762824815775 0.405887942345937 no 2008 0.414196592315091 619 94525 SGTC_770 0389-1121 67.2 µM -0.217499899638503 0.405598930614874 no 2009 0.413909392601075 631 6753108 SGTC_2488 5268135 45.7 µM -0.217710784031103 0.405516250961848 no 2010 0.413827230387822 671 1270356 YLR208W SEC13 SGTC_3169 9102970 49.47 µM -0.218756508886743 0.405106324846538 no 2011 0.413419863580164 620 17027839 SGTC_2477 5967686 25.23 µM -0.219096015610212 0.404973259932196 no 2012 0.413287627229225 641 776118 SGTC_1483 3453-0561 55.9 µM -0.220333777893713 0.404488229456575 no 2013 0.412805607759737 652 4546991 SGTC_2800 7887935 81.82 µM -0.220431018857655 0.404450130745632 no 2014 0.412767744951091 676 2961002 SGTC_1782 st039423 80.636 µM -0.220508769984576 0.404419668744774 no 2015 0.412737471503097 675 2068169 SGTC_2223 6903751 107.57 µM -0.220534634202471 0.404409535568909 no 2016 0.412727401036699 657 5598863 SGTC_2016 5121758 140 µM -0.225246979723036 0.402564392679113 no 2017 0.410893571903967 668 2795203 SGTC_2659 sanguinarine 24.21 µM -0.225786582896636 0.402353245906319 no 2018 0.410683706466437 649 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3095 9117207 49.47 µM -0.22721507036917 0.401794416302307 no 2019 0.410128254839055 638 17015229 SGTC_952 1185-0122 232 µM -0.22739611875182 0.401723603812437 no 2020 0.410057869016984 634 678600 SGTC_1757 st041620 31.8375 µM -0.227846121397303 0.401547610655373 no 2021 0.409882934934186 654 5289815 SGTC_2933 9026794 32.47 µM -0.227945761300508 0.401508644825313 no 2022 0.409844203330275 671 17586027 SGTC_212 3807-4682 38.772 µM -0.229012559783923 0.401091517104803 no 2023 0.409429577114646 641 3125501 YBL034C STU1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.229687032945931 0.400827850214687 no 2024 0.409167485879293 661 5379071 SGTC_3235 9132602 49.47 µM -0.23151153649086 0.40011483699721 no 2025 0.408458712019385 657 4912240 SGTC_825 1988-2224 89.6 µM -0.231574627520587 0.400090187058631 no 2026 0.408434208078256 657 1180859 SGTC_1509 1326-1131 80 µM -0.232373729187913 0.399778009057195 no 2027 0.408123875792549 624 768313 SGTC_546 peri-Naphthalide 147 µM -0.23474336681687 0.398852660921142 no 2028 0.407203963095357 637 223824 A penicillin ester. SGTC_990 3985-0011 41.3 µM -0.235352321481606 0.398614954499057 no 2029 0.406967644345086 692 5399565 YGL099W LSG1 SGTC_450 aminopyrene 156 nM -0.235761378786813 0.398455299439338 no 2030 0.406808919336025 646 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1862 st057513 3.81 µM -0.236114262694376 0.398317582509051 no 2031 0.406672003381993 640 5393163 SGTC_3118 9124250 49.47 µM -0.236238953258658 0.398268923635227 no 2032 0.406623627230547 650 1504786 SGTC_1842 st055362 61.2 µM -0.237318520643399 0.397847702693171 no 2033 0.406204847530543 637 676032 SGTC_3253 9135987 49.47 µM -0.237738148018229 0.397684006399359 no 2034 0.406042096970898 661 4182430 SGTC_1920 st075728 45.7 µM -0.23816585703002 0.397517176003336 no 2035 0.405876228692918 644 3400306 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.238362020286385 0.397440667648233 no 2036 0.405800160982803 640 115019 SGTC_2273 7815444 169.05 µM -0.239475828950696 0.397006330550639 no 2037 0.405368318481279 723 2824616 SGTC_1075 aripiprazole 15.2 µM -0.241510572906283 0.396213198738802 no 2038 0.404579711492213 653 60795 An atypical antipschotic. YIL048W NEO1 SGTC_452 diindolylmethane 8 µM -0.241729104860989 0.396128041682049 no 2039 0.404495037911136 675 3071 Inhibits expression of several cancer promoting factors. SGTC_2930 9013230 14.89 µM -0.241977589434144 0.396031218776123 no 2040 0.404398764160039 653 2995857 SGTC_976 1348-1067 47.6 µM -0.243390633490831 0.395480743195461 no 2041 0.403851399540286 637 5310671 YGL099W LSG1 SGTC_2090 5301565 104.445 µM -0.244376643983431 0.395096749288487 no 2042 0.403469564451669 665 2056344 SGTC_3072 9116419 49.47 µM -0.245767140186405 0.394555404833129 no 2043 0.402931247660571 663 17170162 SGTC_2495 cafestol 54.53 µM -0.246080146907858 0.394433573882201 no 2044 0.402810095545144 684 16667697 An anti-infammatory. SGTC_1022 4477-0945 21.3 µM -0.246368404172276 0.394321385243683 no 2045 0.402698531187026 642 4648966 SGTC_2344 7990960 76.95 µM -0.247441123933116 0.393903963847204 no 2046 0.402283425574636 663 140813 SGTC_1107 amlodipine 47 µM -0.247481302433318 0.393888331778506 no 2047 0.402267880016111 674 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2714 st079313 56.9 µM -0.247508839219506 0.393877618263468 no 2048 0.402257225782322 642 2939799 SGTC_490 phenamil 164 µM -0.24904324777588 0.393280765467432 no 2049 0.401663664088184 660 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1355 1499-0035 1.68 µM -0.249527226539193 0.393092559811706 no 2050 0.401476491537709 663 1548538 SGTC_1311 1190-0148 100 µM -0.249635970079455 0.393050275959856 no 2051 0.401434439483049 651 1961333 SGTC_3068 9116768 49.47 µM -0.250080718390299 0.392877353109411 no 2052 0.401262463404055 672 41904888 SGTC_1113 artemisinin 1.17947 µM -0.250695129969844 0.392638498164171 no 2053 0.401024913096023 673 2240 An anti-malaria and mitochondrial poison. SGTC_1209 2323-2347 50.3 µM -0.250954773094305 0.392537573014122 no 2054 0.400924538115731 640 5412760 SGTC_2839 9003951 25.97 µM -0.25097732552905 0.392528807061519 no 2055 0.400915819918135 677 2990634 SGTC_84 0443-0269 128.823 µM -0.251288805026457 0.392407743028654 no 2056 0.400795414916731 648 6150058 SGTC_3219 9131112 49.47 µM -0.251470620571345 0.392337080835662 no 2057 0.40072513695442 650 17612988 YMR079W SEC14 SGTC_1799 st045822 46.1415 µM -0.251476261420796 0.392334888589269 no 2058 0.400722956623448 659 3674992 SGTC_403 arphamenine a 50 µM -0.252417397880757 0.391969175433218 no 2059 0.400359226936052 675 5487158 An arginine aminopeptidase inhibitor. SGTC_1973 st070275 50.2 µM -0.252469012823415 0.391949121307773 no 2060 0.400339281329469 644 17118334 SGTC_3342 9147791 14.508 µM -0.252791518638972 0.391823823552152 no 2061 0.400214661018062 652 1838168 SGTC_614 0462-0418 107 µM -0.25355439717354 0.391527479876668 no 2062 0.399919915599783 647 5188303 SGTC_3031 9088762 49.47 µM -0.253700904425579 0.391470575659981 no 2063 0.399863317642025 660 205253 SGTC_1696 st025591 34.7925 µM -0.254529921179539 0.391148624811644 no 2064 0.399543095649067 654 2787147 SGTC_964 1287-0107 19.4 µM -0.254667335048713 0.391095266971319 no 2065 0.399490023698532 663 51516812 YPR165W RHO1 SGTC_703 3875-0075 71.8 µM -0.25658234452883 0.390351882061677 no 2066 0.398750602920973 669 2850814 SGTC_1970 st070122 35.8 µM -0.256673854364853 0.390316368993793 no 2067 0.398715278344474 703 102928 SGTC_2333 9017922 200 µM -0.257482530536738 0.390002578368184 no 2068 0.398403149708452 644 3163164 SGTC_229 benomyl 22.8748 µM -0.257568593614008 0.389969187527041 no 2069 0.398369935350762 665 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_94 0334-0113 514.748 µM -0.258260500980554 0.389700770118416 no 2070 0.398102934038132 653 6795178 SGTC_2119 5528445 120.635 µM -0.260029055953995 0.38901491913598 no 2071 0.397420680442339 664 791935 SGTC_316 k060-0003 58.6 µM -0.260494170463135 0.38883460364439 no 2072 0.397241305720422 669 6152314 SGTC_2133 5320837 200 µM -0.260776654316065 0.388725102050998 no 2073 0.397132374416338 688 2841355 SGTC_549 1661-1316 519 µM -0.262036313040905 0.388236917660504 no 2074 0.396646723134001 687 2857282 SGTC_817 1391-0715 46 µM -0.26209173493726 0.388215442792677 no 2075 0.396625359343696 679 1353946 SGTC_288 1315-0019 35.1 µM -0.262184562002278 0.388179474941521 no 2076 0.396589577467697 660 6811474 SGTC_3048 9093155 49.47 µM -0.263727342407152 0.387581832004118 no 2077 0.395995012504806 638 25236002 SGTC_1406 3909-7906 11.9 µM -0.264763599436212 0.3871805557077 no 2078 0.395595789935043 658 X1406 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.265257816344591 0.386989219423948 no 2079 0.395405429247835 662 77254 SGTC_65 0798-0905 34.986 µM -0.266002749282858 0.386700870224155 no 2080 0.395118545830943 760 3602145 SGTC_2620 irigenin 100 µM -0.266928589022115 0.386342582659447 no 2081 0.394762072079338 636 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_902 1120-0002 2.07 µM -0.266944120261562 0.386336573103487 no 2082 0.394756092875618 682 3280475 SGTC_1893 st059353 36.1 µM -0.269477558194446 0.385356667181815 no 2083 0.393781104822691 723 3112488 SGTC_2450 5739737 12.93 µM -0.270271025229453 0.385049912985451 no 2084 0.393475877331565 650 2262825 SGTC_2732 terfenadine 20 µM -0.27042326749324 0.384991064374966 no 2085 0.393417320909518 668 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1321 1326-2144 215 µM -0.271950733125161 0.3844007757525 no 2086 0.392829950657855 695 3513030 SGTC_346 4513-0042 7.16 µM -0.273181181271815 0.383925464242801 no 2087 0.392356972581713 671 2827372 SGTC_1854 st056233 32.9 µM -0.274003989913561 0.383607717702486 no 2088 0.392040777727809 698 5393174 SGTC_1351 1496-0003 46.5 µM -0.276050215204064 0.382817860305063 no 2089 0.391254748949746 660 3891978 SGTC_808 0711-0032 135 µM -0.277281222377028 0.38234291728881 no 2090 0.39078208843565 695 4252555 SGTC_2394 5221648 200 µM -0.277680974930365 0.382188724139377 no 2091 0.390628633135617 677 788586 SGTC_2374 9071832 200 µM -0.277841710429548 0.382126730268308 no 2092 0.390566935479867 690 17381698 SGTC_2674 ligustilide 100 µM -0.278627629658703 0.381823653614164 no 2093 0.390265303337738 653 5319022 A signalling regulator. SGTC_213 1246-0773 967 nM -0.278808084590305 0.381754074393602 no 2094 0.390196054891779 683 6251622 SGTC_2323 6148992 148.28 µM -0.281817886514848 0.380594129670567 no 2095 0.389041577571653 667 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3017 9080681 49.47 µM -0.283177448659068 0.380070520350265 no 2096 0.388520407248619 686 16451914 SGTC_2765 myclobutanil 7.74 µM -0.283891564398269 0.379795580310314 no 2097 0.388246740645662 711 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2645 abamectin 100 µM -0.284315451709014 0.379632409167127 no 2098 0.38808432289861 658 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1167 k781-0610 148 µM -0.284809362049148 0.379442310402461 no 2099 0.387895099640312 679 4525169 SGTC_1001 4048-4355 44.4 µM -0.28485212530637 0.379425852829115 no 2100 0.387878717750445 706 21824233 SGTC_1521 st012942 49.4 µM -0.285032727675235 0.379356349852439 no 2101 0.387809534199596 669 24207259 SGTC_1396 3511-0007 98.6 µM -0.285516514192967 0.37917018876973 no 2102 0.387624227111695 684 X1396 SGTC_1306 1185-0270 9.02 µM -0.286068637148429 0.378957766057078 no 2103 0.387412776062915 668 1548076 SGTC_987 1497-1013 404 µM -0.286494618094647 0.378793899951982 no 2104 0.387249657471203 688 1676435 SGTC_2773 thioridazine 9.09 µM -0.28707401017858 0.378571054710609 no 2105 0.387027825933361 666 5452 An antipsychotic. SGTC_776 4476-4378 112 µM -0.288290873041421 0.378103157571016 no 2106 0.386562046492768 713 2892008 SGTC_3165 9101544 49.47 µM -0.288367777807768 0.378073592841096 no 2107 0.386532615084212 689 5002184 SGTC_100 0086-0128 49.5915 µM -0.288498372701265 0.37802338949038 no 2108 0.386482637991112 710 93297 SGTC_1216 1165-0504 9.65 µM -0.288718672044179 0.377938706581 no 2109 0.386398336353025 682 6304004 SGTC_2267 7931562 200 µM -0.28926566305636 0.377728468996078 no 2110 0.386189043268049 658 934880 SGTC_2726 cimetidine 79.27 µM -0.289688503897812 0.377565973705418 no 2111 0.386027275978871 684 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.290542215131366 0.37723796347907 no 2112 0.385700729928692 666 279621 SGTC_655 k060-0012 42 µM -0.290691025299132 0.377180797164001 no 2113 0.38564381806001 693 5994525 SGTC_1638 st008370 60.6 µM -0.290715205600243 0.377171508411035 no 2114 0.385634570630574 661 24207134 SGTC_1605 st000082 49.1 µM -0.292454654109015 0.37650349391778 no 2115 0.38496951289402 694 1114022 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.294029239928419 0.375899111683409 no 2116 0.384367780091287 661 1241132 A phosphatase inhibitor. SGTC_2171 5739187 198.077 µM -0.29466205910663 0.375656298737895 no 2117 0.384126024685835 657 2262761 SGTC_1944 st076371 56.9 µM -0.295585387903438 0.375302105501811 no 2118 0.38377336701141 657 24208455 SGTC_1130 3454-2858 15.9 µM -0.295925771111105 0.375171559413225 no 2119 0.383643384768869 714 715628 YIL048W NEO1 SGTC_2241 6772625 37.8075 µM -0.295980965422796 0.375150392261207 no 2120 0.383622308932942 641 2285411 SGTC_1097 itavastatin 7.23 µM -0.296673755932587 0.374884737421363 no 2121 0.383357797584662 660 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_942 3253-1115 227 µM -0.297131909246073 0.374709088273268 no 2122 0.383182901903852 707 46497897 SGTC_1200 1643-0193 18.4 µM -0.298149848243764 0.374318918715903 no 2123 0.382794398608224 694 5403974 SGTC_2719 novobiocin 32.65 µM -0.298402614569153 0.374222054915789 no 2124 0.382697946889781 689 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3052 9092717 49.47 µM -0.301589986613115 0.37300128991607 no 2125 0.381482321148024 691 25237534 SGTC_1819 st053448 58.6 µM -0.302301562204661 0.372728929662452 no 2126 0.381211093776973 672 2857616 SGTC_3192 9110362 49.47 µM -0.303677307089342 0.372202534728982 no 2127 0.380686874169818 660 16649480 SGTC_3268 9137683 49.47 µM -0.304999586787357 0.371696821886464 no 2128 0.380183233515931 697 1953228 SGTC_1694 st024011 44.9 µM -0.305090711947412 0.371661978730769 no 2129 0.380148532493837 717 2787533 SGTC_752 1896-0090 130 µM -0.306102956641865 0.371275001620859 no 2130 0.379763128418942 674 772567 SGTC_2727 riluzole 51.77 µM -0.306362356884549 0.371175854868587 no 2131 0.379664383055356 691 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_191 3914-0123 66.505 µM -0.306494051052568 0.371125522608794 no 2132 0.379614254306674 714 3144412 SGTC_1261 0712-0010 12.7 µM -0.306905375150433 0.370968332644528 no 2133 0.379457698808751 698 2840123 SGTC_1419 3993-2473 62.6 µM -0.309067873301088 0.370142275718712 no 2134 0.378634948474821 675 704026 SGTC_1832 st054113 55 µM -0.309476479927108 0.369986258396847 no 2135 0.378479550451247 693 1251267 SGTC_3099 9120367 49.47 µM -0.310044759913446 0.369769308938271 no 2136 0.378263459397331 693 24824940 SGTC_248 streptozotocin 5.23457 mM -0.310970415486494 0.369416014721793 no 2137 0.377911556186826 700 5300 DNA alkylating agent. SGTC_3023 9089636 49.47 µM -0.312500197012688 0.368832386006055 no 2138 0.377330206678695 675 17249241 SGTC_2648 atorvastatin 78.68 µM -0.312743361043122 0.368739644031397 no 2139 0.377237824737846 699 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1108 betulinic acid 729.144 nM -0.313327528020426 0.368516875883622 no 2140 0.3770159189925 662 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1968 st069590 43.6 µM -0.313354286976888 0.368506672593323 no 2141 0.377005755120795 690 6384066 SGTC_1671 st016596 74.5 µM -0.313881854132284 0.3683055282031 no 2142 0.376805386359498 665 2829167 SGTC_1826 st055655 41.6 µM -0.316005054328958 0.367496385649555 no 2143 0.375999335884896 675 676168 SGTC_3070 9117005 49.47 µM -0.31692565860876 0.367145729781656 no 2144 0.3756500060525 689 8779016 SGTC_2915 7971052 15.16 µM -0.317453788362589 0.366944616468385 no 2145 0.375449649449191 699 5741558 SGTC_1254 0550-0035 264 µM -0.317885793405941 0.366780134863134 no 2146 0.375285784652993 706 15121435 SGTC_1925 st057770 10.1 µM -0.319259021597569 0.366257454510597 no 2147 0.374765051984361 693 5989122 SGTC_624 k048-0052 28 µM -0.319770452701653 0.366062856106088 no 2148 0.374571173904761 671 6835531 SGTC_2766 oltipraz 83.91 µM -0.320499179249381 0.365785636785188 no 2149 0.374294976221682 693 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2325 6158266 200 µM -0.322014128238996 0.36520955017437 no 2150 0.373720995672442 675 3623240 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.322865613648328 0.364885890906988 no 2151 0.373398509561248 650 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3280 9140961 49.47 µM -0.323822064923452 0.36452244771355 no 2152 0.373036375071944 690 4901226 SGTC_1232 0279-0259 161 µM -0.324866497337454 0.364125711517495 no 2153 0.372641056997696 687 1560000 SGTC_2536 dehydroabietamide 32.04 µM -0.325580585876271 0.363854542903578 no 2154 0.372370851376165 697 3983547 SGTC_2483 5729050 27.16 µM -0.327351186970423 0.363182467602938 no 2155 0.371701140740703 715 2865180 SGTC_2027 5150920 200 µM -0.328330862932357 0.362810788225512 no 2156 0.371330755584034 697 786715 SGTC_1058 3448-5425 97.3 µM -0.329409736618851 0.362401623713983 no 2157 0.370923004671462 695 7279705 SGTC_547 1120-0019 610 nM -0.329965718544382 0.362190828031364 no 2158 0.370712932689729 701 3676939 SGTC_3161 9100388 49.47 µM -0.331533271600277 0.361596729178493 no 2159 0.370120856763301 684 25236368 SGTC_1349 flufenamic acid 69 µM -0.331757518766591 0.361511767273151 no 2160 0.370036182136147 690 3371 A non-steroidal anti-inflammatory. SGTC_1247 0448-0043 5.84 µM -0.33330640938374 0.360925116205679 no 2161 0.369451500874356 717 3089013 YGL099W LSG1 SGTC_710 3448-4187 58 µM -0.333975186296008 0.360671914180465 no 2162 0.369199141565876 675 3946412 SGTC_2471 5466956 24.79 µM -0.334332229155768 0.360536761103125 no 2163 0.369064436466255 696 724419 SGTC_2755 lomerizine 42.69 µM -0.334829656217407 0.360348496792396 no 2164 0.368876794035052 687 3949 A calcium channel blocker. SGTC_2269 7935389 174.42 µM -0.33595710139561 0.359921911001129 no 2165 0.368451608125179 655 97605 SGTC_1317 1273-0028 910 nM -0.336432710857133 0.359742009304167 no 2166 0.368272292950583 701 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_397 arbidol 50 µM -0.336630608230113 0.359667162768778 no 2167 0.368197689760824 685 131410 A RNA synthesis inhibitor. SGTC_1350 1495-0454 146 µM -0.336837110913732 0.359589067367225 no 2168 0.36811984784677 699 1069057 SGTC_3063 1327-0034 4 µM -0.337421750931422 0.35936799940061 no 2169 0.367899495105657 702 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1651 st011928 86.1 µM -0.337706874647953 0.359260203596539 no 2170 0.367792046804725 686 720198 SGTC_1181 1222-0449 220 µM -0.339302708927282 0.358657078700954 no 2171 0.367190851069897 698 658318 SGTC_3316 9136639 10.545 µM -0.339652250846909 0.358525020843195 no 2172 0.367059212181627 721 4903665 SGTC_3352 9151559 45.5865 µM -0.341394513697103 0.357867041913175 no 2173 0.366403302365571 671 17159339 SGTC_510 ag-490 170 µM -0.342119302680063 0.357593443990633 no 2174 0.366130555778988 701 5328779 SGTC_1608 st001473 40.5 µM -0.34360733914793 0.357031960021548 no 2175 0.365570802294782 723 7292267 SGTC_2326 6164455 177.58 µM -0.34625881041826 0.35603224246743 no 2176 0.364574110333163 702 2888790 SGTC_144 4161-2749 112.381 µM -0.346337515745974 0.356002582289052 no 2177 0.364544538831754 686 797501 YMR168C CEP3 SGTC_1445 4239-0156 97.7 µM -0.346680307472801 0.355873411062585 no 2178 0.364415753064883 732 4008346 SGTC_369 0957-0393 4.5 µM -0.34681426035366 0.355822939257847 no 2179 0.364365431549372 740 6997992 SGTC_210 3551-0445 56.827 µM -0.346954008635728 0.355770286510404 no 2180 0.364312935391488 726 2865180 YOR207C RET1 SGTC_2097 5376186 200 µM -0.347665420644095 0.35550229156495 no 2181 0.364045734395651 683 742755 SGTC_3112 9123419 49.47 µM -0.348014408839172 0.355370850852609 no 2182 0.363914681207682 725 17015854 SGTC_350 k064-0020 19.8 µM -0.348309271923811 0.355259808886615 no 2183 0.363803965662198 704 2790705 SGTC_771 0250-0039 27.3 µM -0.348826007294778 0.355065242071596 no 2184 0.363609968671748 705 3005115 SGTC_3115 9123671 49.47 µM -0.349526529146648 0.354801534315234 no 2185 0.363347028906712 701 3286988 SGTC_2775 cyproheptadine 69.59 µM -0.351989418292814 0.353874945595533 no 2186 0.362423099141992 705 2913 A selective serotonin reuptake inhibitor. SGTC_3034 9090421 49.47 µM -0.353740750580321 0.353216584729355 no 2187 0.361766590041739 716 17173761 SGTC_2004 4023728 41.89 µM -0.354522349440529 0.352922907647269 no 2188 0.361473728919937 713 360084 YDR527W RBA50 SGTC_2343 7990716 14.84 µM -0.354584973567217 0.352899381116227 no 2189 0.361450267486765 678 6456862 SGTC_3279 9140807 49.47 µM -0.355069382848192 0.352717418024931 no 2190 0.36126880653908 694 45595718 SGTC_1921 5740136 50 µM -0.35569649893215 0.352481898714677 no 2191 0.36103393361941 726 1774243 SGTC_3121 9125696 49.47 µM -0.355745361665746 0.352463550231525 no 2192 0.361015635326198 709 1235365 SGTC_705 1124-0212 310 µM -0.356603431532156 0.352141391732453 no 2193 0.360694354089877 723 9554485 SGTC_1489 4065-0444 182 µM -0.356909006615135 0.352026690536531 no 2194 0.360579963424108 688 2877968 SGTC_220 paclitaxel 373.376 µM -0.357064575527353 0.35196830108933 no 2195 0.360521731689154 708 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1434 4073-0095 163 µM -0.357198428795099 0.351918064936108 no 2196 0.360471631028516 711 24133745 SGTC_2180 6301957 200 µM -0.35805948702109 0.351594965040815 no 2197 0.360149398207072 716 845462 SGTC_2236 dapsone 200 µM -0.360548492304387 0.350661604487899 no 2198 0.359218499949346 702 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1450 4112-4260 37.6 µM -0.361746300725645 0.350212754902228 no 2199 0.35877081195696 688 1633175 SGTC_1066 ketoconazole 628 nM -0.362749801966152 0.34983687817653 no 2200 0.358395896703594 730 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1082 camptothecin 424.86 nM -0.36286856327881 0.349792404040732 no 2201 0.358351535649802 688 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1697 st025554 27.742 µM -0.363172094185395 0.349678746132258 no 2202 0.358238166078669 683 1269519 SGTC_141 0443-0274 32.331 µM -0.364522695393015 0.349173173589671 no 2203 0.357733864707124 708 1627241 SGTC_284 0988-0104 32.6 µM -0.365477681276975 0.348815853728863 no 2204 0.357377432013516 707 4666532 SGTC_2868 9035608 32.47 µM -0.365912651264984 0.348653148703378 no 2205 0.357215127867712 682 6462614 SGTC_2521 angolensin 13.4 µM -0.367039379028709 0.348231814020606 no 2206 0.356794822290021 691 821428 A flavenoid. SGTC_282 k297-0036 65.7 µM -0.367171196316874 0.348182533774283 no 2207 0.356745661561538 717 5061378 SGTC_3003 9075612 71.4286 µM -0.367919976565301 0.347902648930644 no 2208 0.356466452140102 744 6501993 SGTC_396 dithiazanine 1.25 µM -0.372694729115096 0.346119859439165 no 2209 0.354687829921836 693 10578 An antihelmenthic. SGTC_841 0251-0215 91.2 µM -0.374572343507204 0.345419729287397 no 2210 0.353989272319996 732 3888614 SGTC_2561 acetosyringone 100 µM -0.374810217766609 0.345331067736972 no 2211 0.353900807328352 726 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_502 l-744,832 89.3 µM -0.376085169566183 0.344856006791316 no 2212 0.353426789669532 735 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2232 chlorophetanol 41.5365 µM -0.376176954760833 0.344821816052007 no 2213 0.353392673372641 712 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1873 rapamycin 2 nM -0.376385813230229 0.34474401927882 no 2214 0.353315045661334 705 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3111 9122088 49.47 µM -0.376786748106391 0.344594695208195 no 2215 0.353166044834048 719 16876704 SGTC_2362 9071156 126 µM -0.376854435414538 0.344569488154736 no 2216 0.353140892183569 728 653133 SGTC_2844 9010103 25.97 µM -0.377075243716444 0.344487262963345 no 2217 0.353058844126877 760 2480525 SGTC_2531 methyl deoxycholate 70.07 µM -0.377355325089862 0.344382976077668 no 2218 0.352954781181622 742 16667744 Haematoxylin. SGTC_2529 gangaleoidin 93.61 µM -0.377657831381948 0.344270352675197 no 2219 0.352842398715182 700 4565183 SGTC_1162 k048-0130 20.1 µM -0.377673607847885 0.344264479459544 no 2220 0.352836538038329 729 6797406 SGTC_2195 6536160 144.242 µM -0.377861350235288 0.344194590167166 no 2221 0.352766797757029 691 3834386 SGTC_524 r073-0010 27.8 µM -0.37825188797529 0.344049224989734 no 2222 0.3526217413519 731 2772106 SGTC_1631 benzylvanillin 81.9 µM -0.37838209281439 0.344000765525775 no 2223 0.352573384472781 714 75506 SGTC_503 tyrphostin 8 294 µM -0.3787134910932 0.34387743771587 no 2224 0.352450316951437 751 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_610 4215-0184 155 µM -0.378735276619292 0.34386933094942 no 2225 0.352442227255091 717 5605015 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.378872772596538 0.343818168003528 no 2226 0.352391171928396 739 61125 An anti-inflammatory. SGTC_2480 5767542 37.17 µM -0.380636826798147 0.343162008575121 no 2227 0.351736375451853 687 2867358 SGTC_3306 9127676 59.7925 µM -0.380660012029303 0.343153387714778 no 2228 0.351727772285251 682 41905287 SGTC_2167 5876490 200 µM -0.381073340350642 0.342999715404676 no 2229 0.351574414448605 743 686534 SGTC_2675 theaflavin digallate 100 µM -0.381536406447385 0.342827581811091 no 2230 0.351402631018292 723 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1235 benzylparaben 21.5 µM -0.38163614261543 0.342790511577573 no 2231 0.351365635905992 730 7180 SGTC_1812 st052057 4.327 µM -0.382675094532265 0.34240444092803 no 2232 0.350980341519745 705 3645418 SGTC_234 nsc-17383 10.7 µM -0.383081245759787 0.342253561381994 no 2233 0.350829762320565 710 408974 SGTC_2349 9023730 187.07 µM -0.383397372390266 0.342136142148028 no 2234 0.350712575649576 725 4126287 SGTC_1747 st037496 66.6 µM -0.383416057344392 0.342129202454244 no 2235 0.350705649668456 695 723305 SGTC_2932 9016711 44.54 µM -0.383969055747273 0.341923839984802 no 2236 0.350500691360962 736 7117328 SGTC_329 k048-0121 21.3 µM -0.384155115977552 0.341854754837373 no 2237 0.350431741467253 709 6832902 SGTC_2722 naftopidil 47.16 µM -0.384561978702192 0.341703703009315 no 2238 0.350280984122308 746 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_223 busulfan 5 mM -0.385808507169257 0.341241074786809 no 2239 0.349819247190944 718 2478 A DNA alkylator. SGTC_2694 st077685 81.9 µM -0.387032652304055 0.34078698586822 no 2240 0.349366017513291 682 2838096 SGTC_1969 st069479 40.1 µM -0.387563129978186 0.3405902800978 no 2241 0.349169679152544 733 3895485 SGTC_2275 7947463 200 µM -0.388579369593974 0.340213570645632 no 2242 0.348793665209438 704 1225414 SGTC_2891 9063876 19.48 µM -0.388592996308129 0.340208520446859 no 2243 0.348788624262251 719 6472478 SGTC_2473 5854593 8.94 µM -0.389192101983686 0.33998651413821 no 2244 0.348567022756617 704 2872951 SGTC_567 1080-0542 68.4 µM -0.389247083876363 0.339966142669243 no 2245 0.348546688246918 689 5950415 SGTC_1904 st060225 78 µM -0.38985190848756 0.339742078548972 no 2246 0.348323028576943 682 66595 SGTC_3258 9138477 49.47 µM -0.389926540817532 0.33971443408044 no 2247 0.348295433746461 706 4970355 SGTC_2260 7964312 200 µM -0.391956177273951 0.338962969934995 no 2248 0.347545296849789 720 231951 SGTC_706 4262-0057 46.9 µM -0.392911169865614 0.338609609383677 no 2249 0.347192545674117 716 883298 SGTC_1572 epiandrosterone 68.9 µM -0.393277725189524 0.338474016513773 no 2250 0.347057184130219 705 441302 A steroid. SGTC_2217 6934799 96.0675 µM -0.394665997610205 0.337960669134837 no 2251 0.346544699933186 726 675606 SGTC_3249 9135183 49.47 µM -0.397544551994137 0.336897214488032 no 2252 0.345482969884085 731 4902779 SGTC_2294 7971431 200 µM -0.397587362835088 0.336881408237957 no 2253 0.345467188618954 764 5741572 SGTC_1050 3232-1156 69.3 µM -0.397696101363306 0.336841262029992 no 2254 0.345427105784685 737 700529 SGTC_3138 9097216 49.47 µM -0.398136156112461 0.336678813033137 no 2255 0.345264911973367 732 25237486 SGTC_2655 perillic acid 100 µM -0.398504755866101 0.33654276554944 no 2256 0.345129076656573 718 5702197 An apoptosis inducer. SGTC_2007 4011539 71.82 µM -0.399308053285642 0.336246348461136 no 2257 0.344833116951001 718 45595301 SGTC_1453 4237-0541 195 µM -0.401106621780181 0.335583045178921 no 2258 0.344170812898859 725 739892 SGTC_1570 verbenone 133 µM -0.401843222617858 0.335311538057813 no 2259 0.343899705097578 740 29025 A natural terpanoid with antifungal properties. SGTC_175 3793-3120 23.7 µM -0.403477537225125 0.334709445700734 no 2260 0.34329847815126 770 5322297 SGTC_2606 farnesol 9.78 µM -0.403582127956114 0.334670928225232 no 2261 0.343260015093677 717 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.404573425546285 0.334305950942952 no 2262 0.342895547810343 717 368090 SGTC_1024 4507-0395 26 µM -0.40597258175906 0.333791074252186 no 2263 0.342381373196393 691 4201836 SGTC_3158 9100007 49.47 µM -0.409253817755729 0.332584837686303 no 2264 0.341176701580243 711 19297233 SGTC_377 3970-0964 33.1 µM -0.410763812174554 0.332030319699394 no 2265 0.340622865362471 719 16481235 SGTC_1055 3448-0672 86 µM -0.412546846906547 0.331376006043121 no 2266 0.339969325585499 741 748378 SGTC_715 0868-0130 184 µM -0.412632549008944 0.331344569200351 no 2267 0.339937925089327 716 2876258 SGTC_432 NS 1619 61.3 µM -0.41318732677266 0.331141096980034 no 2268 0.339734686266317 710 4552 A K+/calcium channel activator. SGTC_861 0443-0273 110 µM -0.413440305502749 0.331048330167433 no 2269 0.33964202479823 725 6149169 SGTC_2611 pyromycin 23.93 µM -0.414292723133412 0.330735826637852 no 2270 0.33932987122786 700 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2389 9091542 195.52 µM -0.418398336570978 0.329232329177596 no 2271 0.337827951280573 712 3626624 YOL127W RPL25 SGTC_697 0508-1955 564 µM -0.418402545721682 0.329230789175219 no 2272 0.33782641280368 745 6243113 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.419860398443654 0.328697578907469 no 2273 0.337293719580562 739 5355888 SGTC_3335 9143315 29.6265 µM -0.422219412991985 0.327835506964017 no 2274 0.336432436508663 704 4899691 SGTC_890 0929-0006 47.2 µM -0.422965305684354 0.327563120458202 no 2275 0.336160287146137 727 1378169 SGTC_1905 st060207 84.5 µM -0.423318437459834 0.327434195121346 no 2276 0.336031472022064 703 1948547 SGTC_2120 5538279 151.968 µM -0.423344285136338 0.327424759167759 no 2277 0.33602204408359 730 2058197 SGTC_2317 5986382 200 µM -0.423691375339088 0.327298061090319 no 2278 0.335895452948678 748 877883 SGTC_1736 st036774 51 µM -0.42509630285331 0.326785424807539 no 2279 0.335383236481488 765 1272247 SGTC_2350 9023895 38.85 µM -0.425112900278673 0.326779370615486 no 2280 0.335377187123853 713 2997209 SGTC_1084 voriconazole 435 nM -0.42595973015472 0.326470535627568 no 2281 0.335068594917644 756 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.425979634208314 0.326463278139618 no 2282 0.335061343044567 773 6708760 SGTC_1657 st012939 43.4 µM -0.427845235831365 0.325783327683656 no 2283 0.334381900210419 733 24207257 SGTC_519 k048-0011 62.8 µM -0.427899872943556 0.325763422970365 no 2284 0.33436200980715 724 6836379 SGTC_2465 5809242 33.21 µM -0.427956773103522 0.325742694339618 no 2285 0.33434129604548 757 2731748 SGTC_1006 4099-6547 255 µM -0.428836092003531 0.325422428497253 no 2286 0.334021255619401 735 3146833 SGTC_2234 tolnaftate 200 µM -0.428965463365681 0.325375319683003 no 2287 0.333974179277833 732 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2182 6325192 200 µM -0.429095117585715 0.325328110669072 no 2288 0.333927002629473 702 736248 SGTC_188 3229-0966 278.469 µM -0.430300839803786 0.324889223739824 no 2289 0.333488408145948 739 5722370 SGTC_3310 9130229 44.1445 µM -0.430376583776756 0.324861660783583 no 2290 0.333460863046546 748 7761258 SGTC_1977 st070720 65.3 µM -0.430750069099027 0.324725764855074 no 2291 0.333325054278485 724 682188 SGTC_889 0919-1524 82.7 µM -0.43188760695144 0.324312005455759 no 2292 0.332911551232821 732 3905452 SGTC_1714 st033236 13.627 µM -0.432865850419909 0.323956359975742 no 2293 0.332556115234231 746 2916566 SGTC_3134 9127454 49.47 µM -0.434157943472502 0.323486859088267 no 2294 0.332086875484265 740 24262820 SGTC_1964 st076914 61 µM -0.435385844801552 0.323040943464925 no 2295 0.33164119162256 747 24208661 SGTC_2320 7373003 200 µM -0.43594734366251 0.32283711832589 no 2296 0.331437467138821 742 5415828 SGTC_2046 4110841 106 µM -0.436035347229666 0.322805177687538 no 2297 0.33140554197321 753 44119630 YMR134W ERG29 SGTC_1984 st072354 53.1 µM -0.436130746564268 0.322770554253451 no 2298 0.331370935219457 727 5762938 SGTC_699 0375-0592 111 µM -0.437090007478568 0.322422493577975 no 2299 0.331023036906782 713 762578 SGTC_2926 9010726 65.15 µM -0.437545502724605 0.322257274986708 no 2300 0.3308578919969 759 2994293 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.439233875760544 0.321645169768016 no 2301 0.330246040711895 785 65057 A dermal irritant. YDR527W RBA50 SGTC_1225 1216-0074 20.6 µM -0.439659198238964 0.321491048967678 no 2302 0.330091979117627 732 4241466 SGTC_2430 5571206 200 µM -0.440324012432578 0.321250206967525 no 2303 0.329851225822122 749 1731771 SGTC_3324 9138759 60.749 µM -0.440880524629022 0.32104865727225 no 2304 0.329649746780597 737 45595710 SGTC_185 k048-0037 25.491 µM -0.440886761856244 0.321046398660336 no 2305 0.329647488941958 749 6827589 SGTC_1698 5-fluorocytosine 1.055 µM -0.441043805921289 0.32098953236822 no 2306 0.329590641983919 739 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1946 st076057 65.1 µM -0.441276996431829 0.320905100885779 no 2307 0.329506238728137 732 953009 SGTC_3098 9119039 49.47 µM -0.441632301652692 0.320776473034674 no 2308 0.329377652777649 731 17161528 SGTC_330 1488-0319 80.1 µM -0.443332790359555 0.320161158980232 no 2309 0.328762520745309 720 6846614 SGTC_455 paf C-16 10 µM -0.445289182062021 0.319453859021373 no 2310 0.328055392318336 742 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2074 5212007 75.395 µM -0.445398889959159 0.319414215420205 no 2311 0.328015757136091 727 758611 SGTC_295 k015-0027 31 µM -0.445738086941214 0.319291657631546 no 2312 0.327893224571183 739 3887424 SGTC_651 3253-0966 34.4 µM -0.446177760954732 0.319132825120916 no 2313 0.327734422943392 732 781462 SGTC_630 4356-0227 183 µM -0.446454851943042 0.319032742880304 no 2314 0.327634359114485 756 779312 SGTC_1860 st056228 74.6 µM -0.446610667791044 0.318976469690594 no 2315 0.327578095921159 779 688679 SGTC_2666 tannic acid 100 µM -0.448017804473985 0.318468468703178 no 2316 0.327070173569302 752 16134267 A thiamine antagonist. SGTC_1915 st067105 30.6 µM -0.448575057250773 0.318267384923868 no 2317 0.32686911513841 745 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_828 2074-0507 139 µM -0.450082321655016 0.317723759348249 no 2318 0.326325541661448 734 X828 SGTC_1795 st049545 62.3 µM -0.450558284106504 0.317552175335056 no 2319 0.326153969106276 701 5291882 SGTC_2918 7977171 22.06 µM -0.451154812428851 0.317337182775945 no 2320 0.32593898752355 748 2236483 SGTC_2908 7930301 100 µM -0.451170169237714 0.317331648898684 no 2321 0.325933453879161 748 2223178 SGTC_2944 9067346 25.62 µM -0.451184358345291 0.317326535842768 no 2322 0.325928341036192 758 6473075 SGTC_1330 1469-0054 61.8 µM -0.451654672180699 0.31715707762083 no 2323 0.325758888667468 745 7102664 SGTC_1992 st073643 23.3 µM -0.452565542151226 0.316828992170966 no 2324 0.325430807900384 753 3161292 SGTC_1227 3909-8010 46.6 µM -0.452769037183962 0.316755715144959 no 2325 0.325357530721396 737 15982272 SGTC_1026 k007-1105 30.6 µM -0.453273494489644 0.316574094880433 no 2326 0.325175908189291 724 7066794 SGTC_231 b-estradiol 524 µM -0.454241684383645 0.316225640409833 no 2327 0.324827441828331 712 450 A steroid. SGTC_772 k072-0172 35.3 µM -0.454286545075115 0.316209498863719 no 2328 0.324811299491028 714 5861980 SGTC_2988 9073640 71.4286 µM -0.454772724870054 0.316034586591731 no 2329 0.324636377279706 764 9102229 SGTC_3348 9149464 3.537 µM -0.454976231594582 0.315961383463765 no 2330 0.324563169249395 728 1951442 SGTC_2403 6032726 181.2 µM -0.455527089357825 0.315763271372574 no 2331 0.32436504169201 730 2881040 SGTC_362 0310-0100 9.03 µM -0.455580718223746 0.315743986956872 no 2332 0.324345755599256 731 790235 SGTC_3198 9112019 49.47 µM -0.45627613742053 0.315493966454508 no 2333 0.324095710597231 793 45595555 SGTC_1214 0358-0031 63.7 µM -0.456289189522881 0.31548927470597 no 2334 0.324091018339999 771 4301366 SGTC_2399 5884133 200 µM -0.456436766252958 0.315436228393926 no 2335 0.324037966151023 745 722445 SGTC_2409 alverine citrate 63.97 µM -0.456837704457292 0.315292130753317 no 2336 0.323893851381795 696 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3317 9138495 8.753 µM -0.457258628998102 0.315140880229741 no 2337 0.323742581047841 759 17020139 SGTC_1435 4092-0789 56.7 µM -0.457557052915703 0.315033666539696 no 2338 0.323635352178567 752 2248285 SGTC_668 1682-0499 62.6 µM -0.458201182675361 0.314802305474599 no 2339 0.323403955142533 747 682214 SGTC_179 1273-0063 6.77 µM -0.458358642677175 0.314745759421082 no 2340 0.323347399629006 776 3108139 SGTC_569 4130-2812 160 µM -0.459484394492611 0.314341613055234 no 2341 0.322943177998934 768 743552 SGTC_2811 7967822 32.47 µM -0.460097835859213 0.314121480404324 no 2342 0.322722998700512 720 2232244 SGTC_1399 3562-5772 25 µM -0.460864982342095 0.31384628390809 no 2343 0.3224477382759 743 23847490 SGTC_1764 st044502 93.5 µM -0.463091246005158 0.313048248579759 no 2344 0.321649482244606 729 8407 SGTC_2796 7949634 45.45 µM -0.463645079114223 0.312849855132942 no 2345 0.321451025766164 722 2971588 SGTC_3 0833-0587 95.581 µM -0.466833233637508 0.311708853468425 no 2346 0.320309598315666 735 5382644 SGTC_37 0566-0070 1.56 µM -0.467409294790257 0.311502880448456 no 2347 0.320103536924188 754 1626686 SGTC_881 0833-0569 170 µM -0.467488975043298 0.311474395089941 no 2348 0.320075039066697 718 5418700 SGTC_1788 fluconazole 20 µM -0.467745925252769 0.311382544148268 no 2349 0.319983147362677 770 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1847 st056231 15 µM -0.467896094072288 0.311328869348944 no 2350 0.319929448418371 742 5393180 SGTC_3203 9113543 49.47 µM -0.469749969142005 0.310666569976482 no 2351 0.319266831384437 727 17018012 SGTC_1234 0326-0494 15.5 µM -0.470956015015771 0.310236037471072 no 2352 0.318836072773605 773 1547813 SGTC_1895 st058434 18.3 µM -0.472505808807175 0.309683176010253 no 2353 0.318282898261249 779 5393175 SGTC_816 0325-0417 81.3 µM -0.47251457840891 0.309680048833473 no 2354 0.318279769241055 744 68101 SGTC_2823 7987624 58.44 µM -0.47349703252198 0.309329800040427 no 2355 0.317929308802737 797 2239440 SGTC_2368 9071271 200 µM -0.474741370006447 0.308886437362597 no 2356 0.317485663473785 763 27209959 SGTC_2960 9079389 5.97 µM -0.474807983576866 0.308862710510673 no 2357 0.317461921030873 746 16457355 SGTC_2771 fluoxetine 41.05 µM -0.476639420561732 0.308210690161922 no 2358 0.316809453736979 768 3386 A selective serotonin reuptake inhibitor. SGTC_3183 9108214 49.47 µM -0.477820113185336 0.307790665458856 no 2359 0.316389122184231 749 4974831 SGTC_2754 granisetron 64.02 µM -0.477911254758329 0.307758252821569 no 2360 0.316356685250441 776 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_606 k015-0008 38.6 µM -0.478166251807078 0.307667576304957 no 2361 0.316265940292526 775 1970475 SGTC_753 1322-0200 289 µM -0.481681599386007 0.306418723960812 no 2362 0.315016074739241 763 5403907 SGTC_2147 5545932 89.7195 µM -0.482068624007685 0.306281367640494 no 2363 0.314878598930764 777 797404 SGTC_2942 9052777 62.25 µM -0.48215682857012 0.306250067357323 no 2364 0.314847271195492 780 6469503 SGTC_1960 st011366 51.8 µM -0.484033959304165 0.305584284042746 no 2365 0.314180884277956 747 3972846 SGTC_767 0929-0023 86 µM -0.484038264640272 0.305582757757688 no 2366 0.314179356565949 754 1204563 SGTC_707 0865-0008 204 µM -0.484252930646347 0.305506660778268 no 2367 0.314103188191306 766 723043 SGTC_1846 st056244 14.8 µM -0.48428650769302 0.305494758806543 no 2368 0.314091275008508 757 5393182 SGTC_1913 st060213 96.1 µM -0.484571345761898 0.305393801238125 no 2369 0.313990221859008 766 688959 SGTC_679 0422-0091 41.4 µM -0.485824685511219 0.304949745325491 no 2370 0.313545735250947 774 627384 YHR062C RPP1 SGTC_851 0394-0702 453 µM -0.486296387231317 0.304782696613644 no 2371 0.313378520173269 768 762646 SGTC_2867 9039098 71.43 µM -0.487054775076203 0.304514206024507 no 2372 0.313109757210628 729 6463460 SGTC_1224 0823-0416 294 µM -0.488091275315289 0.304147426152367 no 2373 0.312742595320698 762 3598164 SGTC_1627 st003713 25.6 µM -0.488496570732695 0.304004060344453 no 2374 0.312599077069832 727 16195070 YER133W GLC7 SGTC_2183 6420625 130.508 µM -0.488879406567012 0.303868666877209 no 2375 0.312463538024901 742 2897619 SGTC_2728 chlorpromazine 9.18 µM -0.489328599920743 0.303709839755753 no 2376 0.312304538132678 803 2726 A thorazine and dopamine antagonist. SGTC_337 1315-0038 354 µM -0.489987081562786 0.30347707885027 no 2377 0.31207152013475 765 1626437 SGTC_966 1300-0360 30.2 µM -0.490261462657537 0.303380113806082 no 2378 0.311974446621488 771 70588 SGTC_2168 5727979 200 µM -0.49110395090042 0.303082468806475 no 2379 0.311676463635144 741 695210 SGTC_764 1951-2361 146 µM -0.491921130767179 0.302793889944956 no 2380 0.311387549832587 750 5438930 SGTC_888 0916-0002 6.97 µM -0.492609954533563 0.302550734371048 no 2381 0.311144106492434 740 2802138 YIL048W NEO1 SGTC_2059 5238311 157 µM -0.493602473962924 0.302200527885259 no 2382 0.310793476626167 737 703021 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.494637094188547 0.301835660106006 no 2383 0.310428156524845 729 6312947 SGTC_2540 epiandrosterone 100 µM -0.495081659321702 0.301678941199706 no 2384 0.310271239818035 748 441302 A steroid. SGTC_273 hydroxyurea 18.1 mM -0.49530828934783 0.301599063256166 no 2385 0.31019126024373 772 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2816 7982706 58.44 µM -0.495326691908883 0.301592577513265 no 2386 0.31018476622472 769 2981853 SGTC_2338 7999974 200 µM -0.49592461960125 0.301381879833278 no 2387 0.309973797712511 775 315925 SGTC_1345 1488-0192 31.4 µM -0.496872385057878 0.301048042205734 no 2388 0.309639523127828 776 658348 SGTC_532 1548-0774 215 µM -0.497359279456358 0.300876605038853 no 2389 0.309467857829221 798 5932993 SGTC_2295 7971645 200 µM -0.497669289982649 0.300767472230732 no 2390 0.309358578475186 750 2978226 YKL099C UTP11 SGTC_2505 galangin 7.89 µM -0.498980903184167 0.300305943636965 no 2391 0.308896418742951 765 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_108 0509-0257 621.132 µM -0.501980309444623 0.299251721710902 no 2392 0.30784068594282 743 536624 SGTC_2715 st079500 56.4 µM -0.502523397548126 0.299061018481762 no 2393 0.307649699097036 760 28246688 SGTC_1369 1866-0067 208 µM -0.503022035848498 0.298885972227809 no 2394 0.307474389727217 761 3531355 SGTC_1171 0368-0077 21.4 µM -0.503983050362205 0.298548740846894 no 2395 0.307136643926321 749 3239779 SGTC_1177 0983-0204 23.6 µM -0.504514983359884 0.29836215369843 no 2396 0.306949767895599 758 766818 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.50490807817411 0.298224301199228 no 2397 0.30681170001706 781 7104 SGTC_1648 st011736 69.8 µM -0.505596661429428 0.297982895235307 no 2398 0.306569912887993 761 2855514 SGTC_1898 st060199 18.6 µM -0.505643525366201 0.297966468747584 no 2399 0.306553460278963 746 688866 SGTC_884 0851-0618 334 µM -0.506570099694528 0.297641775837131 no 2400 0.306228246204969 782 9642473 SGTC_1270 0831-1170 17.3 µM -0.506676626354354 0.297604456801911 no 2401 0.306190866678598 760 6764716 SGTC_921 1561-0023 372 µM -0.507566388436665 0.297292833657336 no 2402 0.305878733661314 771 24050882 SGTC_2779 methotrexate 400 µM -0.507744770280461 0.297230376575969 no 2403 0.305816173366126 749 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1527 coumarin 137 µM -0.507961476570762 0.297154508972288 no 2404 0.305740179927425 808 323 A hepatotoxic, DNA x-linker. SGTC_682 0kpi-0099 17 µM -0.508731766916206 0.296884906521372 no 2405 0.305470126229529 775 1714895 YML126C ERG13 SGTC_2221 6807166 181.081 µM -0.509776437072102 0.296519449791884 no 2406 0.305104047639502 753 674925 SGTC_781 4335-2806 94.4 µM -0.509803689350047 0.296509918892921 no 2407 0.305094500365925 798 845254 SGTC_1985 st071382 65.5 µM -0.510354672688442 0.296317254419622 no 2408 0.30490150317349 783 6123237 SGTC_488 nitrendipine 139 µM -0.510522603946021 0.296258544663968 no 2409 0.304842691381505 758 4507 Dihydropyridine L-type calcium channel blocker. SGTC_449 xestospongin c 11.1929 µM -0.51086373475654 0.296139299754585 no 2410 0.304723238294266 770 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2459 5811157 9.22 µM -0.513517885329366 0.295212274102465 no 2411 0.303794551550316 767 2870684 YBR192W RIM2 SGTC_3006 9075424 71.4286 µM -0.515848074195936 0.294399502809676 no 2412 0.302980261509899 766 7465181 SGTC_3163 9099914 49.47 µM -0.516078692518977 0.294319119212238 no 2413 0.302899724532827 773 16268368 SGTC_2972 9093619 59.92 µM -0.517033757761637 0.2939863326311 no 2414 0.302566296873877 738 25236256 SGTC_698 k064-0052 127 µM -0.51730551160116 0.293891673489232 no 2415 0.302471453588315 781 5088751 SGTC_873 0591-4978 488 µM -0.517679900480473 0.293761286906785 no 2416 0.302340812059174 794 3305145 SGTC_720 r052-1644 49.9 µM -0.519260715729838 0.293211039461564 no 2417 0.301789472083827 782 1422863 YOR257W CDC31 SGTC_371 0195-0006 7.36 µM -0.519283870216419 0.293202983439726 no 2418 0.301781399866742 756 3928593 SGTC_738 1315-0003 72.4 µM -0.519920314699696 0.292981588760692 no 2419 0.301559557852816 790 6251474 SGTC_680 0417-1641 114 µM -0.520452906713364 0.292796380016743 no 2420 0.301373971538248 752 2835990 SGTC_2654 protoveratrine a 100 µM -0.521468975543984 0.292443193186218 no 2421 0.30102005622483 791 5702278 A heart drug and vasodilator. SGTC_2723 salbutamol 83.58 µM -0.522610221726653 0.292046730863164 no 2422 0.300622762907257 776 9884233 β2-adrenoceptor agonist SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.524160633431875 0.291508528005364 no 2423 0.30008340949787 762 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_726 3448-4391 34.2 µM -0.526351242136593 0.290748879593998 no 2424 0.299322093011618 793 1356692 SGTC_169 k015-0017 16.025 µM -0.527391131046321 0.290388596383122 no 2425 0.298961000576153 821 1840002 SGTC_2152 5568786 200 µM -0.527787017455532 0.290251491278584 no 2426 0.298823584459378 776 5399883 SGTC_967 1306-0166 352 µM -0.529111468839092 0.289793022067785 no 2427 0.298364062966423 779 4437607 SGTC_3296 9122258 64.045 µM -0.530333816785727 0.289370198479164 no 2428 0.297940252129039 778 4730474 SGTC_2549 cedrol 20.94 µM -0.531044500182149 0.289124498610282 no 2429 0.297693971169175 779 6708665 A sedative which affects the nervous system. SGTC_2802 7925815 54.55 µM -0.534675923458956 0.287870564565787 no 2430 0.296436986504771 765 1262923 SGTC_693 4161-2696 114 µM -0.536547650465665 0.287225259988186 no 2431 0.29579005644707 787 805759 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.53728487200891 0.286971280420585 no 2432 0.295535426739322 746 4000243 SGTC_2005 4024620 188 µM -0.538140431543573 0.286676665772281 no 2433 0.295240050574636 784 236743 SGTC_1031 k035-0009 16 µM -0.538732762464134 0.286472778790934 no 2434 0.295035631957091 793 5180959 SGTC_3137 9097352 49.47 µM -0.538993665125029 0.28638299498665 no 2435 0.294945612838714 827 44120435 SGTC_1067 clotrimazole 1.36 µM -0.539272682524757 0.286286992182928 no 2436 0.294849357607744 773 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_741 4582-0002 126 µM -0.540453692520776 0.285880805939502 no 2437 0.29444209403481 760 2912688 SGTC_2031 5180455 200 µM -0.54047109244401 0.285874823610922 no 2438 0.294436095726613 792 29949 SGTC_2570 licareol 100 µM -0.542246990187626 0.285264559263748 no 2439 0.293824184074259 778 443158 SGTC_582 0987-0078 156 µM -0.542673547866646 0.285118070719454 no 2440 0.293677295032245 785 1625765 SGTC_2440 5628896 157.78 µM -0.542900058910761 0.285040296819193 no 2441 0.293599307699567 796 5522048 SGTC_1583 clindamycin 39.6 µM -0.543703664976545 0.284764455578377 no 2442 0.293322705001824 786 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2560 caryophyllene 100 µM -0.543795423752481 0.284732967088992 no 2443 0.293291129144624 764 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3122 9126309 49.47 µM -0.543858898290454 0.284711185760047 no 2444 0.293269287328029 801 17591206 SGTC_3301 9125354 19.7965 µM -0.543990842881 0.284665911433159 no 2445 0.29322388713305 755 41905162 SGTC_2923 7992654 58.14 µM -0.544281947318587 0.284566036529535 no 2446 0.293123733899275 748 2985126 SGTC_2149 5554786 194.827 µM -0.545798177589644 0.284046104449668 no 2447 0.292602338064396 769 745063 YPR165W RHO1 SGTC_1382 3002-2117 298 µM -0.545825430086166 0.284036763427106 no 2448 0.292592970516763 810 1497314 SGTC_2259 7964009 200 µM -0.545980040969834 0.283983772027429 no 2449 0.292539828488902 771 313134 SGTC_2313 7726885 200 µM -0.547069046561983 0.28361065985416 no 2450 0.292165648419059 766 726423 SGTC_1418 3966-3099 2.4 µM -0.548241925568632 0.283209074063609 no 2451 0.291762898888826 774 740335 SGTC_823 0417-1665 178 µM -0.549624244973999 0.282736127792037 no 2452 0.291288562979131 795 3429856 SGTC_2136 5328288 199.296 µM -0.549830640716204 0.282665544198895 no 2453 0.291217770218861 768 262395 SGTC_1793 st048256 72.231 µM -0.551241615123708 0.282183243552873 no 2454 0.290734027976014 784 672022 SGTC_1553 gossypol 38.6 µM -0.556777967547215 0.280294638142415 no 2455 0.288839569498586 781 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3321 9137793 26.8275 µM -0.55756310521095 0.2800273020949 no 2456 0.288571378068739 769 4904192 SGTC_2081 5214970 32.255 µM -0.557596202276074 0.28001603540004 no 2457 0.288560075177632 775 2063512 SGTC_1081 sertraline 6 µM -0.558500896389652 0.279708150247607 no 2458 0.288251196292634 786 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1048 3161-0300 24.5 µM -0.560449802722548 0.279045457845295 no 2459 0.287586334848683 757 2165101 SGTC_835 0312-0010 67.2 µM -0.560571486535834 0.279004106675332 no 2460 0.287544846967657 778 1626196 SGTC_2687 chenodiol 100 µM -0.560678791941228 0.278967644117163 no 2461 0.287508263727442 753 5702181 A cholesterol synthesis inhibitor. SGTC_1848 st056003 16.4 µM -0.56069477273983 0.278962214013096 no 2462 0.287502815640392 770 146492 SGTC_1646 st011709 75.6 µM -0.56093288714379 0.278881311381945 no 2463 0.287421644754371 788 5757843 SGTC_736 0958-0254 92.6 µM -0.561373828760626 0.278731525577504 no 2464 0.287271360670678 808 6812352 SGTC_2449 5812982 45.77 µM -0.562354395994407 0.278398571923859 no 2465 0.286937291852838 792 776185 SGTC_1352 1496-0991 99 µM -0.562894571739283 0.278215236953303 no 2466 0.286753338383123 803 3000039 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.566672748591767 0.276934576903514 no 2467 0.285468269465283 790 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2300 7976697 71.57 µM -0.566727748553479 0.276915955317614 no 2468 0.285449582628327 768 2236109 SGTC_728 3030-5151 22.5 µM -0.567899343086672 0.276519428956553 no 2469 0.285051659020307 788 3125388 SGTC_1014 4130-3005 69.3 µM -0.568477760190871 0.276323766289826 no 2470 0.284855301401149 787 743608 SGTC_3184 9108758 49.47 µM -0.569153305068368 0.276095333977374 no 2471 0.284626053148285 787 902885 SGTC_138 0850-0259 40.9225 µM -0.569167497737848 0.27609053578768 no 2472 0.28462123776674 775 6813004 SGTC_1779 st039427 55 µM -0.571065450897966 0.275449253924822 no 2473 0.283977638504598 812 1124498 SGTC_12 0849-0099 9.267 µM -0.571313426757037 0.275365521807797 no 2474 0.283893600916466 799 6071388 SGTC_2787 5284540 71.43 µM -0.571998500389775 0.275134263338354 no 2475 0.283661495300613 798 736958 SGTC_2292 7671323 168.05 µM -0.572996973947025 0.274797382665869 no 2476 0.28332337144017 789 937504 SGTC_2280 7785178 200 µM -0.573284874939577 0.274700283895099 no 2477 0.28322591233557 775 2954328 SGTC_1236 0330-0013 258 µM -0.573619312307545 0.274587511305129 no 2478 0.28311272011584 790 4617066 SGTC_80 0159-0065 512.242 µM -0.573758418520736 0.274540611287385 no 2479 0.283065645224133 768 1548079 SGTC_1387 3342-1166 1.8 µM -0.574154112050369 0.274407223809935 no 2480 0.282931759241517 767 3418228 SGTC_1983 st071813 46.9 µM -0.575431421443503 0.273976863840184 no 2481 0.282499779295097 790 11838595 SGTC_1897 st060201 15 µM -0.579057784313758 0.272756865351118 no 2482 0.281275091907638 782 611878 SGTC_765 1319-0117 244 µM -0.579861438454365 0.272486861454979 no 2483 0.281004030949988 774 3487746 YGL099W LSG1 SGTC_2639 lactacystin 53 µM -0.581561382244374 0.271916168533088 no 2484 0.28043108064755 775 3870 A proteasome inhibitor. SGTC_1787 fluconazole 80 µM -0.582497369048203 0.271602199776426 no 2485 0.280115856576218 779 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3077 9117319 49.47 µM -0.582875473400903 0.271475419118737 no 2486 0.279988566320988 816 17154678 SGTC_3236 9132701 49.47 µM -0.582961480603482 0.271446584503791 no 2487 0.279959615587652 794 24282524 SGTC_3186 9110464 49.47 µM -0.583896964347536 0.271133054545266 no 2488 0.279644817833365 789 17018021 SGTC_39 0986-0283 58.349 µM -0.583955670351002 0.271113385089687 no 2489 0.27962506852463 773 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1702 st027038 51 µM -0.584476967023806 0.270938755779061 no 2490 0.279449728617749 779 5521182 SGTC_1233 0325-0408 14.2 µM -0.584592617547677 0.270900021587606 no 2491 0.279410836409706 802 12874 SGTC_1378 2093-0007 380 nM -0.584778316979625 0.270837832083553 no 2492 0.279348392898495 820 3618014 SGTC_3222 9128301 49.47 µM -0.585560459914352 0.270575975855692 no 2493 0.279085463027012 786 4911358 SGTC_2438 5259590 200 µM -0.586091085099123 0.27039839812064 no 2494 0.278907153412525 794 1201127 SGTC_1274 0865-0114 173 µM -0.586349205923 0.270312037096792 no 2495 0.278820435347862 785 870624 SGTC_3155 9099265 49.47 µM -0.586579763658419 0.270234909680835 no 2496 0.278742988452566 801 25236499 SGTC_275 trichlorophene 5.69 µM -0.586711203425564 0.270190944667267 no 2497 0.278698841067063 786 62616 SGTC_1659 st012954 42.1 µM -0.587590916639986 0.269896783351903 no 2498 0.278403454698402 802 24207262 SGTC_2556 citropten 84.59 µM -0.589371050261992 0.269302027418049 no 2499 0.277806196116247 763 2775 A potential DNA crosslinker. SGTC_1587 estradiol valerate 56.1 µM -0.589454411590021 0.269274191894525 no 2500 0.277778242619695 808 13791 A steroid. SGTC_2397 5161689 200 µM -0.590279510158758 0.268998757688843 no 2501 0.277501636985362 801 2259942 SGTC_880 0833-0487 87.2 µM -0.590483193522497 0.268930785928193 no 2502 0.277433374998873 800 76075 SGTC_3000 9075062 71.4286 µM -0.590714549451254 0.268853589937775 no 2503 0.277355848849272 793 17057871 SGTC_2684 capsaicin 100 µM -0.59185595659788 0.268472902239239 no 2504 0.276973524463516 807 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_6 0844-0013 19.835 µM -0.594315037907656 0.26765365936104 no 2505 0.276150711257451 818 1584900 SGTC_285 1486-1325 46 µM -0.595912358441968 0.267122187942009 no 2506 0.27561688838756 786 22310230 SGTC_2853 9015042 58.44 µM -0.597530886352637 0.266584204228664 no 2507 0.275076496082207 785 6457456 SGTC_1328 1441-0025 69.2 µM -0.599984818671048 0.265769586205842 no 2508 0.274258176565425 804 4562601 SGTC_3084 9116877 49.47 µM -0.601383943192662 0.265305692240166 no 2509 0.273792145390809 805 27241325 SGTC_232 clozapine 119 µM -0.602721032445675 0.264862751118706 no 2510 0.273347143669035 786 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_588 3970-1144 52.9 µM -0.603072224436647 0.264746473173811 no 2511 0.27323032155932 771 1888707 SGTC_2026 5148700 152 µM -0.60339295263524 0.264640304322504 no 2512 0.273123654678243 772 79838 SGTC_2880 9042983 58.44 µM -0.605956295677336 0.263792554196715 no 2513 0.272271887560106 814 6464714 SGTC_2833 9001315 45.46 µM -0.60684226816164 0.263499867288896 no 2514 0.271977797132895 786 2989378 SGTC_401 neomycin 50 µM -0.60775125301437 0.26319975044328 no 2515 0.271676232248673 767 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1634 st006576 41 µM -0.608285603733569 0.263023406974209 no 2516 0.271499033734063 801 3915356 SGTC_2877 9040724 71.43 µM -0.609849585850542 0.262507617500469 no 2517 0.270980725442826 798 6463895 SGTC_420 mitomycin C 81.9 mM -0.611072436458194 0.26210469159861 no 2518 0.27057581331287 792 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_477 mead ethanolamide 10 µM -0.611521338860193 0.261956859068639 no 2519 0.270427247949952 768 16061185 SGTC_1806 st050005 60.3 µM -0.613887931756367 0.261178200154437 no 2520 0.269644692768608 787 5194765 SGTC_1437 4092-1038 11.6 µM -0.614029089536002 0.261131793888488 no 2521 0.269598052364373 807 3977136 SGTC_1706 st031321 9.9705 µM -0.6144459093403 0.260994787208088 no 2522 0.269460353161913 799 6103185 SGTC_1612 st002233 45.4 µM -0.615415413919952 0.260676258704579 no 2523 0.269140207277233 797 1035021 SGTC_165 k038-0023 64.381 µM -0.61577202604886 0.260559144959611 no 2524 0.269022496289109 798 46368543 SGTC_2307 7538926 6.34 µM -0.620292941158598 0.259076799020086 no 2525 0.267532470696089 815 96582 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.620499050450043 0.259009322697921 no 2526 0.26746463948436 805 2724278 An inhibitor of dopamine biosynthesis. SGTC_1253 0550-0034 176 µM -0.624699722605087 0.257636084239754 no 2527 0.26608407761515 802 5969915 SGTC_1223 0764-0573 147 µM -0.624949380815848 0.25755458785225 no 2528 0.26600214055196 803 1609797 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.62505917828227 0.257518750703411 no 2529 0.265966109405419 834 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1375 2910-0797 186 µM -0.626069272891267 0.257189184228365 no 2530 0.265634752712101 828 742508 SGTC_2502 avocadyne acetate 18.59 µM -0.626453564637387 0.257063857863012 no 2531 0.265508742645127 786 3952079 SGTC_453 enantio-paf c16 10 µM -0.627621787632165 0.256683068646053 no 2532 0.265125866186814 828 13871343 A lipid and platelet activating factor SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.629381448147763 0.256110051717644 no 2533 0.264549680243152 809 804 An inhibitor of viral and cellular DNA polymerases. SGTC_224 benfluorex 43.875 µM -0.629730102448154 0.255996594958435 no 2534 0.264435592011074 824 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_804 1595-0054 20.9 µM -0.62986559630267 0.255952510527384 no 2535 0.264391261858703 812 761523 Stimulates phospholipase C. SGTC_3028 9087778 49.47 µM -0.629983775720711 0.255914062775052 no 2536 0.264352599639586 799 17217395 SGTC_2569 tetrandrine 100 µM -0.630105439399221 0.255874484623818 no 2537 0.264312800556774 783 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1730 st033808 45.1 µM -0.632033909392069 0.2552475650453 no 2538 0.263682359840621 818 1045166 SGTC_649 1123-0311 367 µM -0.632384232077628 0.255133766120589 no 2539 0.263567917399651 811 693629 YIL048W NEO1 SGTC_2774 tamoxifen 10.92 µM -0.633434964599122 0.254792605069525 no 2540 0.263224819098351 815 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_447 ml7 120 µM -0.634704724800462 0.254380647097999 no 2541 0.262810505783634 823 4216 Selective myosin light chain kinase inhibitor. SGTC_441 propafenone 146 µM -0.635078450167447 0.254259463061429 no 2542 0.262688625532552 823 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3051 9093778 49.47 µM -0.636299222578258 0.253863826908959 no 2543 0.262290705786267 840 17217378 SGTC_3276 9139060 49.47 µM -0.636409280403592 0.253828174512946 no 2544 0.262254846806679 827 4870619 SGTC_2921 7974240 10.71 µM -0.636520538203624 0.253792136065973 no 2545 0.262218599404767 807 2979074 YDR527W RBA50 SGTC_951 1171-0579 82.7 µM -0.637876637466462 0.253353086590749 no 2546 0.26177699341016 818 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3135 9127742 49.47 µM -0.639021028812011 0.252982890341098 no 2547 0.261404625944764 821 3643468 SGTC_204 PMA1.184 62.41 µM -0.639115625177208 0.252952302344897 no 2548 0.261373857908861 818 2252213 YGL008C PMA1 SGTC_3332 9141069 11.198 µM -0.63952082277965 0.252821302606486 no 2549 0.261242086005585 812 17332883 SGTC_3016 9080866 49.47 µM -0.64321770149439 0.251627758968004 no 2550 0.260041424404145 818 17066299 SGTC_1284 0929-0043 16 µM -0.644156578404223 0.251325115562323 no 2551 0.2597369523635 808 1239883 SGTC_3124 9127567 49.47 µM -0.644246406977263 0.251296169752982 no 2552 0.259707831152908 806 17592030 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.644429982731584 0.251237020908127 no 2553 0.259648323613117 818 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_949 1165-0505 146 µM -0.644517597000275 0.251208793834609 no 2554 0.259619925233069 805 6244267 SGTC_2127 5253358 187.912 µM -0.647604678448501 0.250215286838139 no 2555 0.258620335280928 809 20612 SGTC_372 0155-0182 15.9 µM -0.647719593369667 0.25017834435126 no 2556 0.258583164597007 791 771486 SGTC_575 k072-0246 11.9 µM -0.648009742340644 0.250085081048473 no 2557 0.2584893245566 814 6796779 SGTC_394 menadione 8.33 µM -0.648653696450199 0.249878159194188 no 2558 0.258281119818638 823 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2777 climbazole 1.536 µM -0.648704965274577 0.24986168888309 no 2559 0.258264547199482 814 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_812 4251-0442 148 µM -0.651607652070932 0.248930130058431 no 2560 0.257327155041417 821 5723007 SGTC_3266 9136860 49.47 µM -0.653410479400723 0.248352480858506 no 2561 0.256745842354856 814 4871271 YPR165W RHO1 SGTC_2677 mitomycin C 100 µM -0.65382466011301 0.248219873009024 no 2562 0.25661238848411 834 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3025 9087895 49.47 µM -0.654640330128325 0.247958831145399 no 2563 0.256349675728247 820 17173641 SGTC_2278 7948257 134.34 µM -0.655504298092347 0.247682492161195 no 2564 0.256071560012683 818 1247028 SGTC_1420 4'-methoxyflavone 42 µM -0.656302416785499 0.247427361195801 no 2565 0.255814781429582 812 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.656759423468607 0.247281335212877 no 2566 0.25566780928856 816 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2132 5317594 122.667 µM -0.657018756174644 0.247198491902739 no 2567 0.255584428190337 834 794577 SGTC_1759 st043059 70 µM -0.657122577662857 0.247165330498366 no 2568 0.255551051308468 836 669426 SGTC_2083 5306046 65.942 µM -0.657279731241169 0.247115138929282 no 2569 0.255500533378581 824 539837 SGTC_13 0199-0087 65 µM -0.657970979023385 0.246894433575046 no 2570 0.255278389728266 808 4589825 SGTC_1746 st038117 42 µM -0.65811526557183 0.246848378293141 no 2571 0.25523203365412 816 2898218 SGTC_170 4197-0004 226 µM -0.6582104227542 0.246818007286371 no 2572 0.255201464166421 833 218692 SGTC_2130 NSC 7 2.4545 µM -0.658492305977729 0.246728051280298 no 2573 0.255110919698375 804 21448 SGTC_2759 disulfiram 3.38 µM -0.659847489113916 0.246295823542256 no 2574 0.254675852357095 814 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_538 2922-0838 53.3 µM -0.660199285770417 0.246183686457282 no 2575 0.254562975286447 809 777039 SGTC_1626 st003712 1.76 µM -0.662307527996724 0.245512246910427 no 2576 0.25388707663582 835 24207035 SGTC_86 0417-1630 471.922 µM -0.664420791980877 0.244840196624825 no 2577 0.253210514493893 822 3634867 SGTC_885 0865-0106 16.8 µM -0.664737991786629 0.24473940776488 no 2578 0.253109044770958 829 2793380 SGTC_2451 5856223 45.7 µM -0.664773514380244 0.244728122006091 no 2579 0.253097682704594 825 2179896 SGTC_852 0418-0143 439 µM -0.665504533124278 0.244495934826621 no 2580 0.252863922553357 815 5369229 SGTC_1728 st035614 33.7865 µM -0.666357861796636 0.244225049591467 no 2581 0.252591194800113 822 15945546 SGTC_2105 5350118 200 µM -0.666592596494301 0.244150562535297 no 2582 0.252516199699947 818 2133313 SGTC_1699 st031318 29.054 µM -0.666642974161332 0.24413457806722 no 2583 0.25250010613027 817 5340658 SGTC_2607 solasodine 47.35 µM -0.666928623208269 0.244043954370759 no 2584 0.252408863359678 835 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2238 6671620 73.2395 µM -0.667478796673489 0.243869460022074 no 2585 0.252233174483044 796 729941 SGTC_160 3453-0671 289.699 µM -0.66827376484228 0.243617444969011 no 2586 0.251979428382328 837 5322268 SGTC_2256 7954252 200 µM -0.670043504563954 0.243056920291074 no 2587 0.251415028777178 832 2972920 SGTC_534 k292-0788 63.4 µM -0.670652998054137 0.242864038731971 no 2588 0.25122080590263 845 4146317 SGTC_3273 9137859 49.47 µM -0.670793504825255 0.242819585421805 no 2589 0.251176042884651 860 2377234 SGTC_2552 juarezic acid 87.02 µM -0.671180865508496 0.242697055667904 no 2590 0.251052658344767 813 1549512 SGTC_2852 9023854 51.95 µM -0.671347789087722 0.242644264799433 no 2591 0.25099949869392 845 19798528 SGTC_3218 9131285 49.47 µM -0.671802538962309 0.242500478192546 no 2592 0.250854706089643 834 17156417 SGTC_2245 6637752 200 µM -0.671928839354625 0.242460551671883 no 2593 0.250814499823814 827 681890 SGTC_2087 5276107 200 µM -0.673698703942585 0.241901430666277 no 2594 0.250251443014121 824 144405 SGTC_994 3910-0338 138 µM -0.674437577616204 0.241668218928844 no 2595 0.250016579515328 825 3479481 SGTC_1929 genistein trimethyl ether 50.5 µM -0.67454330323218 0.241634858588503 no 2596 0.249982982407088 817 136420 SGTC_1751 st044839 27.194 µM -0.675703774977645 0.241268851232269 no 2597 0.249614369368351 808 5291326 SGTC_2995 9067767 71.4286 µM -0.675797335949682 0.241239355669547 no 2598 0.249584663179851 812 11673567 SGTC_3355 9151058 44.0485 µM -0.676490565606412 0.241020872631374 no 2599 0.249364616990893 827 17015728 SGTC_418 lividomycin a 100 µM -0.677270366376886 0.240775233898264 no 2600 0.249117214547787 827 72394 An antibiotic. SGTC_2756 carbadox 75.1 µM -0.67895088061632 0.240246332139902 no 2601 0.248584492652877 824 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_264 promethazine 12.5 mM -0.680422123825928 0.239783813689675 no 2602 0.248118608226735 850 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1034 k072-0165 12.7 µM -0.681340867089559 0.239495232639846 no 2603 0.2478279150426 839 5835461 SGTC_2976 9009005 19.48 µM -0.682211512573697 0.23922193439733 no 2604 0.247552608015871 804 2993148 SGTC_1503 4585-0012 61.3 µM -0.683297086514968 0.238881408302361 no 2605 0.247209567408823 828 2922052 SGTC_731 3966-0296 387 µM -0.68334667188685 0.238865860547445 no 2606 0.247193904538875 809 660956 SGTC_2735 sertaconazole 140 nM -0.684599914544586 0.238473083524014 no 2607 0.246798210494824 857 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2019 4016004 108 µM -0.686301138112065 0.237940471701669 no 2608 0.246261615716143 836 45595336 SGTC_133 0724-0033 378.92 µM -0.687540873813289 0.237552751707547 no 2609 0.245870976391672 824 280309 SGTC_153 4077-0274 519.67 µM -0.688630099621074 0.237212389138722 no 2610 0.245528037224235 833 3121976 SGTC_1266 0828-0227 32.9 µM -0.691048700444583 0.236457580611434 no 2611 0.244767468389579 848 3913820 SGTC_1849 st056239 19.2 µM -0.691270819217848 0.236388327059794 no 2612 0.244697683129597 825 5393181 SGTC_1934 st074720 32.6 µM -0.691355186400688 0.236362025469035 no 2613 0.244671179461828 835 17250992 SGTC_2513 baicalein 25.65 µM -0.691422613129001 0.23634100624776 no 2614 0.244649998692493 843 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3336 9143619 71.43 µM -0.692922195903225 0.235873800976202 no 2615 0.244179189784074 833 45595730 SGTC_1494 4358-1428 177 µM -0.693116641507038 0.235813257427903 no 2616 0.244118177454943 832 1564571 SGTC_961 1252-1571 372 µM -0.694611138042502 0.235348209673961 no 2617 0.243649515123611 843 6813498 SGTC_2893 9048488 25.97 µM -0.694856001486603 0.235272062949862 no 2618 0.243572774225875 853 6467338 SGTC_2222 6885208 172.143 µM -0.694895919094539 0.235259650810049 no 2619 0.243560265171965 819 609514 SGTC_2177 5811945 192 µM -0.695254547379355 0.235148153721195 no 2620 0.243447896732784 825 5343475 SGTC_1573 oleylamine 1.06 µM -0.696419967477578 0.234786027650529 no 2621 0.243082930953601 841 5356789 An amine of the fatty acid oleic acid. SGTC_190 3970-0790 3.722 µM -0.697130032161619 0.234565543470476 no 2622 0.242860710521646 828 2832352 SGTC_1617 st002906 78 µM -0.698567051416343 0.234119681206371 no 2623 0.242411320383843 843 5150859 SGTC_3293 9120939 62.045 µM -0.698752398130415 0.234062208089589 no 2624 0.242353390871806 837 934087 SGTC_1966 st070145 16.1 µM -0.699097935998657 0.233955083067494 no 2625 0.242245414166629 847 3748532 SGTC_1911 st060208 74.3 µM -0.699425581162453 0.233853530306051 no 2626 0.242143052820094 849 688783 SGTC_476 mead acid 10 µM -0.701513093217871 0.233207085335323 no 2627 0.241491433217604 855 5312531 An omega 9 fatty acid. SGTC_1090 efavirenz 20.7 µM -0.701932037392074 0.23307746947746 no 2628 0.241360774089156 830 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3159 9100096 49.47 µM -0.702116530581317 0.233020402382197 no 2629 0.241303247056726 828 25236875 SGTC_1719 st032227 49.2 µM -0.702752626023001 0.232823706013196 no 2630 0.241104962548912 830 3125804 SGTC_2610 ononetin 44.17 µM -0.702926266415643 0.232770028162268 no 2631 0.241050850532595 843 259632 SGTC_2845 9003024 42.97 µM -0.703373231657385 0.23263188841602 no 2632 0.240911591950128 816 2990173 SGTC_2701 st077767 14.721 µM -0.704266388643611 0.232355984549939 no 2633 0.240633446925411 824 5721188 SGTC_1851 st056236 18.9 µM -0.704742079579052 0.232209113857008 no 2634 0.240485379654724 815 5393171 SGTC_1189 1431-2119 7.28 µM -0.704785879414414 0.232195593152965 no 2635 0.240471748671336 848 3107275 SGTC_3011 9081274 71.4286 µM -0.706012436807212 0.231817141403842 no 2636 0.24009020164665 838 6625322 SGTC_72 0744-0168 198.391 µM -0.7072551673818 0.23143405014198 no 2637 0.239703960431769 858 677577 SGTC_1508 1080-0625 72.9 µM -0.708933512774409 0.230917234519049 no 2638 0.239182868586471 824 767111 SGTC_580 1123-0028 41 µM -0.709177288914718 0.230842221767443 no 2639 0.23910723261136 861 1677248 YPR107C YTH1 SGTC_2622 2-methoxyxanthone 59.94 µM -0.709782456229013 0.230656063585747 no 2640 0.23891952498248 834 71034 A hepatoprotective. SGTC_323 4013-0906 34.3 µM -0.709934308502608 0.230609364806644 no 2641 0.238872436889371 808 2910086 SGTC_1408 3909-7976 48.8 µM -0.71153247510993 0.230118204833107 no 2642 0.238377167013485 844 24152374 SGTC_3305 9127027 53.8275 µM -0.712381855067262 0.229857405688348 no 2643 0.238114174235716 844 41905295 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.712680994366674 0.229765595429128 no 2644 0.238021589869265 845 4174840 SGTC_1772 st048439 82.2 µM -0.713616909783747 0.229478481865889 no 2645 0.237732049178934 826 2927068 YDL195W SEC31 SGTC_3267 9137951 49.47 µM -0.714160884423507 0.229311697574683 no 2646 0.237563850581348 873 16643986 SGTC_2065 5221596 34.26 µM -0.714382421812193 0.22924379301129 no 2647 0.237495369272706 831 788581 SGTC_2627 acetyl isogambogic acid 100 µM -0.716714730109054 0.228529589779776 no 2648 0.236775067527043 850 6857789 A caspase activator and apoptosis inducer. SGTC_1456 k015-0012 13 µM -0.718103645434267 0.228104868367844 no 2649 0.236346691303531 852 2989616 SGTC_574 1315-0397 40 µM -0.718992731701832 0.227833224659068 no 2650 0.236072699012545 853 6794277 SGTC_1011 4112-3381 17.4 µM -0.719277911638169 0.227746131828578 no 2651 0.2359848513685 851 2877139 SGTC_1373 2887-0003 58.5 µM -0.723532917779182 0.226448897401628 no 2652 0.23467626895512 858 776948 SGTC_2050 5263056 171 µM -0.723940888619337 0.226324737889981 no 2653 0.234551012958928 833 763468 YGL055W OLE1 SGTC_3089 9117425 49.47 µM -0.725192239218194 0.225944148959137 no 2654 0.234167051642474 856 9401657 SGTC_2490 carminic acid 95.39 µM -0.725852062348577 0.225743614479908 no 2655 0.233964733367236 824 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2904 7225135 42.03 µM -0.727908432178788 0.225119285600321 no 2656 0.233334820549244 879 4446116 SGTC_2858 9025781 8.96 µM -0.728534528238357 0.224929392716626 no 2657 0.233143220139107 831 4894980 YPL153C RAD53 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.731761431105831 0.223952124772931 no 2658 0.232157096915752 825 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_22 0964-0034 14.468 µM -0.733025669117806 0.223569908885033 no 2659 0.23177138678244 859 138402 SGTC_2818 7996756 12.99 µM -0.733061097734909 0.223559203131392 no 2660 0.23176058290543 876 2241621 SGTC_2203 7227154 166.4 µM -0.733544068344345 0.223413289053631 no 2661 0.231613330092575 843 896304 SGTC_1392 3455-1037 33.9 µM -0.734643637811038 0.223081291600562 no 2662 0.231278277155903 822 981132 SGTC_811 0416-0114 265 µM -0.739964468245565 0.221478726252578 no 2663 0.229660777260039 838 6612453 SGTC_1669 st015249 58.4 µM -0.740857823617942 0.221210305903252 no 2664 0.229389825289588 863 722793 SGTC_31 0508-1974 57.237 µM -0.741467323277528 0.221027280573169 no 2665 0.229205068765903 826 6810525 SGTC_261 5-fluorouridine 15.376 µM -0.741529375522414 0.221008651901256 no 2666 0.229186263663164 832 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2270 7924575 90.91 µM -0.742922396066825 0.220590690517303 no 2667 0.228764332778711 858 1262135 SGTC_1412 3909-8563 178 µM -0.744424907784393 0.220140385504168 no 2668 0.228309727447066 870 23767530 SGTC_2900 5328528 85.29 µM -0.748195765837588 0.219012578635111 no 2669 0.227171042295677 850 795359 SGTC_2695 st077686 51.995 µM -0.749191579610025 0.218715301317454 no 2670 0.226870871808003 865 2876092 SGTC_2730 imipramine 71.33 µM -0.749760948347753 0.218545433769885 no 2671 0.226699346230543 844 3696 A tricyclic antidepressant. SGTC_2329 6138490 200 µM -0.749894423348545 0.218505623344725 no 2672 0.226659146717285 882 720019 SGTC_2290 7904846 200 µM -0.750058019571926 0.218456834621259 no 2673 0.226609880892109 844 2962154 SGTC_1323 1348-1351 11.2 µM -0.750673097544123 0.218273458236156 no 2674 0.226424708680064 830 6989654 SGTC_1919 st067113 52.3 µM -0.750694668701583 0.21826702872524 no 2675 0.22641821612958 863 1268243 SGTC_2922 7999257 32.47 µM -0.750805725790216 0.218233928716153 no 2676 0.226384791504093 874 2988377 SGTC_45 0kpi-0036 14.9 µM -0.750864748424164 0.218216338492816 no 2677 0.226367028716459 851 2795021 SGTC_1597 7-benzyloxygramine 47.5 µM -0.75121654978781 0.21811150982336 no 2678 0.226261170867691 851 260807 SGTC_925 2064-1272 59.6 µM -0.751386819837127 0.218060783712481 no 2679 0.226209946258874 865 6815817 SGTC_3331 9141060 1.957 µM -0.753040812202161 0.217568387525862 no 2680 0.225712694793686 855 4906567 YPR165W RHO1 SGTC_1707 st032323 6.317 µM -0.754102257886046 0.21725273177127 no 2681 0.225393910866857 849 3132057 YMR211W DML1 SGTC_1643 st009866 20.2 µM -0.755567815431932 0.216817335105865 no 2682 0.224954179289869 830 3156273 YOR207C RET1 SGTC_139 0099-0334 718.624 µM -0.756393436886673 0.216572276838369 no 2683 0.224706670899405 878 97690 SGTC_118 0083-0097 135.343 µM -0.758648307280426 0.215903810566856 no 2684 0.224031483544 877 5207356 SGTC_723 4182-0001 115 µM -0.758924456045028 0.215822027302778 no 2685 0.223948874199667 874 744821 YLR208W SEC13 SGTC_507 nimesulide 162 µM -0.760142299166205 0.215461569345876 no 2686 0.223584765443232 851 4495 A COX2 inhibitor. SGTC_999 SEC7.066 22.7 µM -0.761032636137276 0.215198267977378 no 2687 0.223318787119655 857 740511 YDR170C SEC7 SGTC_876 0720-0963 56.8 µM -0.762267445668861 0.214833404260791 no 2688 0.222950199646605 869 765861 SGTC_3245 9134821 49.47 µM -0.763371511918804 0.214507477326242 no 2689 0.222620932340649 875 17014901 SGTC_2287 7945887 168.79 µM -0.763764148586126 0.214391637975367 no 2690 0.22250390258526 854 1245853 SGTC_2191 5911152 200 µM -0.763915089699127 0.214347115595656 no 2691 0.222458922233577 842 2875902 SGTC_2685 mycophenolic acid 18.85 µM -0.7642361016476 0.214252446114811 no 2692 0.222363278129619 837 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_695 3505-6186 243 µM -0.764799292673688 0.214086414502109 no 2693 0.22219553452048 857 1819379 SGTC_2315 7733312 200 µM -0.769550301158697 0.212688775834171 no 2694 0.220783347750805 863 726316 SGTC_66 0109-0187 42.4 µM -0.769855821355741 0.212599081429414 no 2695 0.22069271134596 848 759417 SGTC_818 4072-2707 53.5 µM -0.769957495228139 0.212569236985234 no 2696 0.220662553241344 866 882871 SGTC_2380 9035439 200 µM -0.773611396420408 0.211498328404584 no 2697 0.219580315323814 870 6462575 SGTC_2957 9076800 11.52 µM -0.776076055255381 0.210777758073649 no 2698 0.218852040385696 879 16459615 SGTC_760 0568-0725 82.9 µM -0.77621622650469 0.210736820775998 no 2699 0.21881066339546 880 3916171 SGTC_1713 st033146 12.748 µM -0.777101360764544 0.210478423252709 no 2700 0.218549485608237 871 674619 SGTC_1206 3978-0017 132 µM -0.777635276683355 0.210322646971513 no 2701 0.21839202913152 862 3873677 SGTC_2107 5363541 170.161 µM -0.779371844786703 0.209816451075786 no 2702 0.217880352109094 862 244052 SGTC_3061 glucosamine 200 µM -0.781663323907481 0.2091496001984 no 2703 0.217206230634616 842 91431 and experimental redox chemotherapeutic SGTC_2793 7325131 81.82 µM -0.783230038516235 0.208694384545058 no 2704 0.216746019154803 847 4176441 SGTC_2366 9070441 60.58 µM -0.783246907174845 0.208689486463631 no 2705 0.21674106717432 866 6837235 SGTC_2634 4'-methoxyflavone 100 µM -0.78372222382484 0.208551498623106 no 2706 0.216601559635088 866 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_438 sphingosine 6.67 µM -0.786316031919133 0.207799445769212 no 2707 0.21584118121906 861 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2720 fluspirilene 36.88 µM -0.78638229897394 0.207780253200929 no 2708 0.215821775228222 881 3396 An atypical antipsychotic. SGTC_759 3486-0358 89.3 µM -0.788139313021586 0.207271760745168 no 2709 0.215307611005976 875 875103 SGTC_2822 7994718 71.43 µM -0.788712951725443 0.207105905073556 no 2710 0.215139898147585 900 1018011 SGTC_1114 scopoletin 1.73284 µM -0.789618027914318 0.206844380880998 no 2711 0.214875438283943 872 5280460 A coumarin with genotoxic properties. SGTC_2146 5545642 200 µM -0.790832610422895 0.206493731359869 no 2712 0.214520838743175 859 825326 SGTC_1384 3089-0840 101 µM -0.792223269131977 0.206092681438019 no 2713 0.214115251499095 855 1069836 SGTC_1558 st069300 45.6 µM -0.793928923137459 0.205601421669577 no 2714 0.213618405323777 851 24208000 SGTC_1958 st076513 41.9 µM -0.796507410158503 0.204860091099278 no 2715 0.212868585098162 889 732122 YGL099W LSG1 SGTC_2892 9047358 58.44 µM -0.799572810392484 0.203980841235413 no 2716 0.211979172949202 861 6466771 SGTC_2731 amoxapine 43.43 µM -0.801234498856115 0.203505159790658 no 2717 0.211497951320048 900 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2104 5389443 200 µM -0.802016361829499 0.203281569735449 no 2718 0.211271746857516 884 2244536 SGTC_1953 st076800 12.1 µM -0.802091020026345 0.203260227334568 no 2719 0.211250154558441 862 297591 SGTC_916 4466-0038 42 nM -0.804740626015913 0.202503655596028 no 2720 0.210484685269381 884 5722064 YGL116W CDC20 SGTC_3243 9134147 49.47 µM -0.804997072265476 0.202430519087612 no 2721 0.210410684638176 876 24282180 SGTC_505 gw-5074 63.9 µM -0.80559139595176 0.202261083247445 no 2722 0.210239244157105 882 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_912 3474-0017 2.18 µM -0.806304446415507 0.202057911555173 no 2723 0.210033663668747 872 3360550 SGTC_2281 7943571 200 µM -0.807453137951868 0.20173086827015 no 2724 0.209702731464272 868 1244024 SGTC_2093 5331342 194.4 µM -0.809366541053148 0.201186808771698 no 2725 0.209152170967856 862 33839 SGTC_2971 9092186 9.93 µM -0.810057395896812 0.200990586607968 no 2726 0.20895359445945 860 25236400 SGTC_2299 7976368 114.88 µM -0.812092422334559 0.200413249543619 no 2727 0.20836930048156 876 2979718 SGTC_365 0121-0052 13.6 µM -0.812822891200245 0.200206258703161 no 2728 0.208159804544231 841 3101739 SGTC_1681 tripelennamine 100 µM -0.814404371913369 0.19975855951351 no 2729 0.207706667453518 851 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2626 ethyl orsellinate 100 µM -0.814412123390016 0.199756366642925 no 2730 0.207704447881416 890 75653 A natural product. SGTC_2807 7945238 51.95 µM -0.81497203734488 0.199598006890252 no 2731 0.207544158151544 884 17148797 SGTC_2 0422-0095 29 µM -0.815904571537826 0.199334427184344 no 2732 0.207277358646372 852 6790840 SGTC_2143 5623677 140.463 µM -0.815992180737167 0.1993096753206 no 2733 0.207252303942276 847 5375313 SGTC_2526 patulin 37.61 µM -0.817254379905676 0.198953276873978 no 2734 0.206891535793773 888 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1883 5-benzylidenerhodanine 20 µM -0.817406156850667 0.198910446551888 no 2735 0.206848179188666 851 1273210 SGTC_315 k915-0449 187 µM -0.817824842293597 0.198792325454794 no 2736 0.206728605381139 861 20970215 YNL149C PGA2 SGTC_3288 9119690 36.221 µM -0.817956837129883 0.198755095349031 no 2737 0.206690917011226 894 17595618 YKL019W RAM2 SGTC_3054 9094397 49.47 µM -0.818812152977693 0.198513949174685 no 2738 0.206446798043475 883 2598354 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.820335849059666 0.198084798622653 no 2739 0.206012337575163 874 16725076 SGTC_3220 9131269 49.47 µM -0.820678835003568 0.197988273581935 no 2740 0.205914614786576 887 17722206 SGTC_1070 indatraline 8.81 µM -0.820873103733519 0.197933613983289 no 2741 0.205859276374675 879 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1176 0848-0131 83.3 µM -0.821110915412897 0.197866715516831 no 2742 0.205791546550079 884 6769040 SGTC_3257 9139206 32.98 µM -0.822121411537446 0.197582606651721 no 2743 0.205503900251744 866 4910041 SGTC_237 nikkomycin 200 µM -0.822175182731687 0.197567495374671 no 2744 0.205488600517536 906 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1000 4048-0884 8.67 µM -0.822882146110754 0.197368882989022 no 2745 0.205287508294265 895 13040088 SGTC_155 k072-0202 43.6 µM -0.82357093831016 0.197175491750343 no 2746 0.205091697253071 874 5857737 SGTC_608 k048-0125 159 µM -0.82467221505174 0.196866526100401 no 2747 0.20477885511131 870 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2938 9059746 27.26 µM -0.825272164373827 0.196698332390196 no 2748 0.204608545658393 899 6471769 SGTC_2789 5281112 71.43 µM -0.825842112822496 0.196538629964628 no 2749 0.204446830730019 879 765948 SGTC_198 3454-2873 16.191 µM -0.826595258554569 0.196327715282103 no 2750 0.204233252849657 876 710957 SGTC_1675 st018485 24.5 µM -0.826962504489111 0.196224919684357 no 2751 0.204129157057822 891 3323024 SGTC_897 1000-0139 31.4 µM -0.827914326157999 0.195958647770461 no 2752 0.203859510519518 888 6151020 SGTC_2429 5902844 64.44 µM -0.830042970402914 0.195363953816479 no 2753 0.203257244548897 879 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_591 4299-0174 154 µM -0.832581637300561 0.194656144292849 no 2754 0.202540359368141 886 5509088 SGTC_683 panaxydol 45 µM -0.832844744160421 0.19458287641511 no 2755 0.20246614809277 861 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2518 prenyletin 46.28 µM -0.833024862327524 0.194532728237881 no 2756 0.202415353780122 856 3873459 A coumarin with calcium channel inhibitory activity. SGTC_659 k018-0002 107 µM -0.833985272011493 0.194265465507348 no 2757 0.202144641636923 900 6797879 YHR007C ERG11 SGTC_963 1269-2853 151 µM -0.834139854135708 0.194222469306912 no 2758 0.202101089586233 867 3668223 SGTC_2099 5377090 177.372 µM -0.837523779724475 0.193282700971208 no 2759 0.201149108048705 888 2243829 SGTC_338 4055-0136 114 µM -0.838188890364178 0.193098316339815 no 2760 0.200962312771186 886 2900563 SGTC_1731 st035964 63 µM -0.838332657948359 0.193058474635009 no 2761 0.200921949554155 915 6739575 SGTC_2121 5257820 149.641 µM -0.839192373473785 0.192820330060003 no 2762 0.200680683151322 875 791256 SGTC_3314 9135860 59.4275 µM -0.840927857406719 0.192340141291446 no 2763 0.200194175558541 872 25252478 SGTC_1159 4092-0538 61.2 µM -0.841440899538281 0.192198328506532 no 2764 0.200050490493826 911 717301 SGTC_1335 1486-0900 202 µM -0.842389119419659 0.191936394266555 no 2765 0.199785090676915 872 X1335 SGTC_1273 0849-0096 14.1 µM -0.844230697954735 0.191428305171914 no 2766 0.199270251791815 892 5286025 SGTC_283 0987-0079 11.7 µM -0.845138605318552 0.191178118328222 no 2767 0.199016727985846 879 411556 SGTC_2952 9073731 13.78 µM -0.845811227238899 0.190992897086867 no 2768 0.198829030615498 900 16457353 SGTC_424 splitomicin 100 mM -0.846468795448512 0.190811927653086 no 2769 0.198645637228419 908 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2235 salicylic acid 500 µM -0.848135320564084 0.19035375449118 no 2770 0.198181306528417 881 338 A COX inhibitor and kinase inhibitor. SGTC_2264 7948757 110.76 µM -0.851040633859502 0.189556622201183 no 2771 0.197373390592121 874 2971411 SGTC_2361 9034121 116 µM -0.853689868229018 0.188831543512328 no 2772 0.19663842470482 915 6496917 SGTC_3295 9122362 53.5725 µM -0.853965792465931 0.188756123193391 no 2773 0.19656197165626 916 4730473 SGTC_2186 6124449 200 µM -0.854375116365423 0.18864427400835 no 2774 0.196448589428736 868 3834182 YLR033W RSC58 SGTC_1667 st014849 34.6 µM -0.85470754125308 0.188553467818939 no 2775 0.196356537307019 885 5348460 SGTC_2911 7942208 15.64 µM -0.858741166546677 0.187453779186666 no 2776 0.195241666505271 857 1243384 SGTC_1884 5633444 25 µM -0.858741829201369 0.187453598853177 no 2777 0.195241483667912 881 5724239 SGTC_530 4358-1714 28 µM -0.860837905454506 0.18688371363331 no 2778 0.194663662434446 869 1564641 SGTC_2883 9059145 45.46 µM -0.862973027531296 0.186304316107038 no 2779 0.194076148476335 913 16476510 SGTC_271 rotenone 740 µM -0.863376820902832 0.186194865972077 no 2780 0.193965159677958 902 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_947 3447-0010 211 µM -0.864692409761903 0.185838545779735 no 2781 0.19360381828937 900 748350 SGTC_1804 st050076 49.1 µM -0.866082856366938 0.185462410795698 no 2782 0.193222362925608 900 3895976 SGTC_3205 9113483 49.47 µM -0.866162675356445 0.185440833009412 no 2783 0.193200479301843 897 17018033 SGTC_427 1354-0053 47.3 µM -0.866589795925397 0.185325394282149 no 2784 0.193083403229987 922 6813657 SGTC_1686 st019653 115.5 µM -0.868871916626678 0.184709357329255 no 2785 0.192458595846696 911 97252 SGTC_386 1509-0011 3.07 µM -0.871333791024528 0.18404622683547 no 2786 0.191785962614618 887 3107280 SGTC_1512 0259-0544 12.2 µM -0.872689593100642 0.183681661697102 no 2787 0.19141614581414 881 18476 SGTC_1263 0774-1208 64.8 µM -0.873550085127366 0.183450515332025 no 2788 0.191181659627051 900 906585 SGTC_2347 9049783 174.81 µM -0.875953761835188 0.182805798143699 no 2789 0.19052758545881 918 6467988 YPL169C MEX67 SGTC_1930 st074634 34.3 µM -0.879640498590534 0.181819689141061 no 2790 0.189527046158867 910 684253 YOR116C RPO31 SGTC_3294 9122953 26.2835 µM -0.880055303389141 0.181708947954176 no 2791 0.189414675445586 902 16459826 SGTC_2419 paclitaxel 166.5 µM -0.880170046929408 0.181678322116752 no 2792 0.189383598636279 899 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_743 1275-0778 158 µM -0.880317345598058 0.181639011826997 no 2793 0.189343709290336 899 2849257 YMR203W TOM40 SGTC_121 0557-0495 61.343 µM -0.881606880369389 0.181295094904116 no 2794 0.188994716550594 914 3104427 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.88224988857066 0.181123758075408 no 2795 0.188820844427522 912 364106 SGTC_573 3702-0553 84.7 µM -0.882638359137455 0.181020294856 no 2796 0.188715848133413 891 1222756 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.883423338598023 0.18081134057564 no 2797 0.188503792794403 915 5377381 SGTC_1304 1165-0502 251 µM -0.883740929463145 0.18072684379889 no 2798 0.188418040165886 892 767425 SGTC_2058 5236698 133 µM -0.884126645562085 0.180624255231302 no 2799 0.188313925421852 876 766665 SGTC_2388 9080168 200 µM -0.888588383424145 0.179440226371458 no 2800 0.187112168229659 899 15943073 SGTC_2603 homopterocarpin 100 µM -0.888619620319425 0.179431954151554 no 2801 0.187103771411295 907 101795 A weak amylase inhibitor. SGTC_202 3594-0513 34.79 µM -0.888912387997599 0.179354434456812 no 2802 0.187025083593679 892 708429 SGTC_2092 5303694 80.6725 µM -0.891869528534856 0.17857261693995 no 2803 0.186231434506619 898 1963699 SGTC_2703 st077852 53.4 µM -0.8945353932785 0.177869650350766 no 2804 0.185517750815551 906 6281836 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.895047878930545 0.177734712388171 no 2805 0.18538074708672 922 279621 SGTC_913 3487-1245 167 µM -0.898187900519871 0.176909352403587 no 2806 0.1845426914248 890 4016153 SGTC_2598 perillyl alcohol 100 µM -0.898560235324432 0.176811644463086 no 2807 0.184443473673336 913 10819 An apoptosis inducer. SGTC_2581 avocatin a 64 µM -0.898700737436488 0.176774782825205 no 2808 0.184406042060432 919 6710728 A skin care supplement. SGTC_2340 7987427 183.45 µM -0.899523763369797 0.176558954235278 no 2809 0.184186872045426 883 2239331 SGTC_2310 7668677 200 µM -0.900539448435485 0.176292832962044 no 2810 0.183916620920733 908 2197143 SGTC_1147 3809-1045 12.3 µM -0.902991577939237 0.175651393341666 no 2811 0.183265182410141 882 325925 SGTC_2706 st078239 82.5 µM -0.903566916838335 0.17550110793022 no 2812 0.183112545186014 909 15434492 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.904797820805233 0.175179854864439 no 2813 0.182786253185321 910 641818 YHR062C RPP1 SGTC_1560 lithocholic acid 53.1 µM -0.906725425458526 0.174677520093916 no 2814 0.182276007278975 875 9903 A bile acid which acts as a detergent. SGTC_1368 1852-0141 284 µM -0.908010877025351 0.174343039564476 no 2815 0.181936237481123 911 2838987 SGTC_2673 kobusone 100 µM -0.908732470395787 0.17415545603123 no 2816 0.181745680036517 937 6710676 An epoxy ketone and protein crosslinker. SGTC_3110 9122132 49.47 µM -0.909173846203185 0.174040780379356 no 2817 0.18162918365333 890 918317 SGTC_2805 7950783 58.44 µM -0.90961483078844 0.173926254324562 no 2818 0.181512837206027 896 1178958 YDL195W SEC31 SGTC_2421 5690543 90.72 µM -0.910158288589794 0.173785181363282 no 2819 0.181369519089579 909 3397993 SGTC_426 0988-0037 14.6 µM -0.910522505537348 0.173690677209038 no 2820 0.181273509186191 918 5383008 SGTC_1386 3228-0095 33.8 µM -0.913121290998568 0.173017313953844 no 2821 0.180589376888329 910 870181 SGTC_3015 9080845 49.47 µM -0.916151699514595 0.172234217506579 no 2822 0.179793667397297 905 5296973 SGTC_858 0438-0351 2.77 µM -0.916456105323977 0.172155680333495 no 2823 0.179713859955486 910 2799119 SGTC_1451 4152-0210 104 µM -0.920451581904633 0.171126960510411 no 2824 0.178668411959652 923 659563 SGTC_539 4859-0462 2.54 µM -0.92056437459727 0.17109797682243 no 2825 0.178638954547834 894 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3030 9087619 49.47 µM -0.922552117251146 0.170587713318686 no 2826 0.178120329292624 888 25236973 SGTC_2681 menadione 3.18 µM -0.922594390870871 0.170576872059723 no 2827 0.178109309929531 919 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3194 9111903 49.47 µM -0.922908026083706 0.170496452683327 no 2828 0.178027568812981 908 17087251 SGTC_2248 tofa 1.1 µM -0.923876509156954 0.170248276675388 no 2829 0.177775307419282 885 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_627 1391-0720 175 µM -0.924409975224475 0.170111673676669 no 2830 0.177636451538796 938 997839 SGTC_2342 7990637 118.86 µM -0.925824664054124 0.169749758936576 no 2831 0.177268553693714 940 2033102 YER133W GLC7 SGTC_2792 7535235 81.82 µM -0.926038454740115 0.169695108619291 no 2832 0.177212998096347 907 1281891 SGTC_2557 derrustone 83.84 µM -0.926592218581135 0.169553605026926 no 2833 0.177069148292035 907 629853 An antioxidant. SGTC_664 1222-0054 14.9 µM -0.928286346925752 0.169121173663576 no 2834 0.176629527167639 896 6813991 SGTC_134 0269-0018 6.916 µM -0.928362551319887 0.16910173892144 no 2835 0.176609768595052 913 4378915 SGTC_592 k241-0073 46.5 µM -0.929740019994431 0.168750684308898 no 2836 0.176252854147536 903 4230158 SGTC_2360 9040895 200 µM -0.929970910269104 0.168691886659035 no 2837 0.176193073112563 918 4914414 SGTC_868 0527-0199 213 µM -0.931575368855753 0.168283664978989 no 2838 0.175778008673404 908 2849450 SGTC_1039 k821-0043 94 µM -0.932202784003444 0.168124204992884 no 2839 0.175615868492009 903 15992768 SGTC_2268 7933382 153.85 µM -0.932646157395901 0.168011578577943 no 2840 0.175501346593698 912 935025 YOR257W CDC31 SGTC_2850 9015429 58.44 µM -0.932708121938776 0.167995842114361 no 2841 0.175485345125576 925 6457570 SGTC_1455 4262-0120 131 µM -0.935809982139018 0.167209308734215 no 2842 0.174685515527352 916 1529587 SGTC_1245 0418-0076 17.2 µM -0.936168508984335 0.167118550985446 no 2843 0.174593217102873 941 6790114 SGTC_2882 9058044 58.44 µM -0.936345886819274 0.167073661176159 no 2844 0.174547564765196 896 18076804 SGTC_1740 st038286 13.222 µM -0.938242715223424 0.166594108443906 no 2845 0.174059845650924 900 716786 SGTC_268 camptothecin 39.6153 µM -0.938510324119205 0.166526523627068 no 2846 0.173991106921281 926 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_444 curcumin 90.4 µM -0.94206248166539 0.165631100722417 no 2847 0.1730803258026 899 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_896 0964-0007 44.5 µM -0.942969134135254 0.165403052735009 no 2848 0.172848345456925 895 6756758 SGTC_3217 9129673 49.47 µM -0.943572180364159 0.165251482599044 no 2849 0.172694157006655 923 17248312 SGTC_2211 7117706 200 µM -0.945000056828674 0.164892957460507 no 2850 0.172329423506471 906 822771 SGTC_2015 5119600 184 µM -0.946030971701743 0.164634418695817 no 2851 0.172066394693419 926 2828786 SGTC_1559 coumarin 343 70.1 µM -0.946050889185016 0.164629426262506 no 2852 0.172061315448319 916 108770 A hepatotoxic, DNA x-linker. SGTC_3350 9150499 3.57 µM -0.946936703902762 0.1644074908394 no 2853 0.171835516720748 926 4910996 YPR165W RHO1 SGTC_1255 0566-0045 221 µM -0.948251486511663 0.164078437904171 no 2854 0.171500720922223 914 2788469 SGTC_2197 6588183 93.1375 µM -0.949555474479417 0.163752508824314 no 2855 0.171169085888792 891 884136 SGTC_3092 9117248 49.47 µM -0.95391632537369 0.162665578222789 no 2856 0.170062999534464 956 17141857 SGTC_2534 helenine 20.12 µM -0.955534015396052 0.162263569390136 no 2857 0.169653856063131 901 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1654 st012436 41.8 µM -0.957020649737693 0.161894699758203 no 2858 0.169278416201345 915 4323132 SGTC_2945 9067681 61.76 µM -0.958939442948943 0.161419409404872 no 2859 0.168794626504722 945 16456930 SGTC_460 trequinsin 123 µM -0.960623018631415 0.161003133301406 no 2860 0.168370875239264 951 5537 A vasodilator. SGTC_1432 4049-0298 68.4 µM -0.960709013491498 0.160981889282879 no 2861 0.168349248955896 921 741646 SGTC_259 usnic acid 108.925 µM -0.965288338161259 0.159853263890146 no 2862 0.167200205620682 945 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1054 3429-0080 167 µM -0.968468917920976 0.159072428042281 no 2863 0.166405117404549 930 1162877 SGTC_3274 9138298 49.47 µM -0.968543949366892 0.1590540379596 no 2864 0.166386390403003 947 17015756 SGTC_2585 alliin 100 µM -0.972036396961646 0.158199586264183 no 2865 0.165516220909394 916 87310 A garlic compound which reacts with lipids. SGTC_1690 st023502 41.2 µM -0.972283342933068 0.158139283450282 no 2866 0.165454804095855 906 24207482 SGTC_1043 0916-0009 19.3 µM -0.972577137930825 0.15806756002259 no 2867 0.165381754878967 915 3101130 SGTC_1144 3486-0183 12.5 µM -0.974874863980434 0.157507358662118 no 2868 0.164811167949601 937 6744069 SGTC_959 1222-0044 107 µM -0.975256099827866 0.157414537100358 no 2869 0.164716620357746 901 6083612 SGTC_882 0843-0131 351 µM -0.976114594114635 0.157205646502408 no 2870 0.164503839980167 920 5425421 SGTC_38 0929-0051 58.268 µM -0.976505729201818 0.157110535174522 no 2871 0.164406955078573 927 1379719 SGTC_1195 1502-0147 41.1 µM -0.976557364865807 0.157097981889349 no 2872 0.164394167591352 912 817940 SGTC_570 0987-0065 62.6 µM -0.976681594576276 0.157067782773056 no 2873 0.164363404949765 875 3104428 SGTC_2903 5923464 63.88 µM -0.980656801892927 0.156103461878476 no 2874 0.163381006558261 930 2876576 SGTC_2651 TUB2.036 5 µM -0.981289952367043 0.155950230774698 no 2875 0.163224888080384 896 15992207 YFL037W TUB2 SGTC_2445 5742597 35.57 µM -0.981635242017995 0.155866707732274 no 2876 0.163139789471846 926 1774255 SGTC_1102 cgs 12066b 26.1 µM -0.981656945668203 0.155861458763227 no 2877 0.163134441446499 908 6438352 A 5-HT1B full agonist. SGTC_1524 corynanthine 62.1 µM -0.983138310600201 0.155503470089725 no 2878 0.162769685639846 955 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3146 9095609 49.47 µM -0.984220467108258 0.155242297816212 no 2879 0.162503562271741 933 17173999 SGTC_2842 9000675 19.48 µM -0.986381803419736 0.154721538779872 no 2880 0.161972895503234 897 2989072 SGTC_1101 ebselen 5.29 µM -0.986467581837918 0.154700894904159 no 2881 0.161951857887345 928 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2405 ticlatone 3.52 µM -0.988657317627337 0.154174518083951 no 2882 0.161415416215053 949 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_941 3237-0776 460 µM -0.988700819968889 0.154164072844835 no 2883 0.161404770759614 929 760008 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.989003786991366 0.154091341167764 no 2884 0.161330644415477 915 165521 SGTC_2458 5808907 16.39 µM -0.989786449690523 0.153903556588994 no 2885 0.161139254662723 912 2731747 SGTC_2431 5490079 200 µM -0.994674321770573 0.152734234938503 no 2886 0.159947343624462 950 5722345 SGTC_601 0986-0029 62.9 µM -0.995304685806881 0.152583863576857 no 2887 0.159794049739118 906 24747981 SGTC_803 4488-1585 147 µM -0.999577564166416 0.151567172002785 no 2888 0.158757492626256 915 747204 SGTC_2514 salinomycin 42.74 µM -0.999774569746439 0.151520405217928 no 2889 0.15870980760157 940 23682228 A polyether potassium ionophore. SGTC_1029 k015-0030 64.7 µM -1.00041437755585 0.151368588621168 no 2890 0.158555007468289 918 2208316 SGTC_332 4112-0506 40.9 µM -1.0019710224074 0.150999643229964 no 2891 0.158178794230773 925 2790355 SGTC_1051 3253-3903 78 µM -1.00215990621972 0.150954916020409 no 2892 0.158133184278432 913 5509239 SGTC_1735 st034310 56.75 µM -1.003653339294 0.150601585338551 no 2893 0.157772867550063 904 871153 SGTC_1433 4060-0023 7.6 µM -1.00465815293219 0.150364167128986 no 2894 0.157530742469472 923 3840627 SGTC_3109 9122853 49.47 µM -1.00513852951509 0.15025075150715 no 2895 0.157415074763938 959 1234709 SGTC_106 0092-0003 11.579 µM -1.00672871392142 0.149875720067296 no 2896 0.157032579791314 929 1072148 SGTC_304 1310-0298 97 µM -1.00734013720124 0.14973168741272 no 2897 0.156885673959021 929 1550234 SGTC_3029 9088683 49.47 µM -1.00761745003552 0.149666391425389 no 2898 0.156819074201173 928 25236615 SGTC_375 3970-0961 9.27 µM -1.01192936141776 0.148653554625731 no 2899 0.155785914684997 911 2898222 SGTC_1268 0828-0275 2.46 µM -1.01318274302242 0.148360005879428 no 2900 0.155486440850336 932 745337 SGTC_399 oxolinic acid 75 µM -1.01588333579428 0.147728830986802 no 2901 0.154842472612539 915 4628 A DNA gyrase inhibitor. SGTC_3150 9097574 49.47 µM -1.01632421351679 0.147625961292902 no 2902 0.154737510905329 925 17217476 SGTC_788 1182-0090 188 µM -1.01672278631555 0.147533003882097 no 2903 0.154642661387052 929 5715185 SGTC_1879 gemcitabine 100 µM -1.02069786700962 0.146608058944597 no 2904 0.153698802704629 942 60750 A nucleoside analog which inhibits DNA replication. SGTC_2709 st078560 56 µM -1.02089817726002 0.146561552808689 no 2905 0.153651341407461 940 17250903 SGTC_2990 9074105 71.4286 µM -1.02389592463684 0.145866747110558 no 2906 0.152942217673657 937 6502001 SGTC_2400 5203494 178.7 µM -1.02523992987622 0.145555958916773 no 2907 0.152624995887162 927 6777674 SGTC_732 3970-1727 52.7 µM -1.02992894109459 0.144475159197723 no 2908 0.151521681901846 943 1275699 SGTC_632 0781-2353 4.65 µM -1.03274034634734 0.14382974032387 no 2909 0.150862713462673 960 6811515 YHR007C ERG11 SGTC_334 1502-1024 68.5 µM -1.03861799084624 0.142486692680403 no 2910 0.149491217637456 945 3296216 SGTC_2992 9074591 71.4286 µM -1.0426729340249 0.141565094000854 no 2911 0.148549898726913 939 17741321 SGTC_475 α-linolenic acid 10 µM -1.0435482330344 0.141366689115028 no 2912 0.148347227077687 929 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3168 9103419 49.47 µM -1.04433081222206 0.141189460774002 no 2913 0.148166180972936 946 16649256 SGTC_2339 9000433 200 µM -1.04575668184932 0.140866935824718 no 2914 0.147836692809893 942 2988954 SGTC_3067 9117431 49.47 µM -1.04771021093732 0.140425868884956 no 2915 0.147386070817964 980 17150885 SGTC_54 0159-0055 9 µM -1.05199551574393 0.139461622061667 no 2916 0.14640080350354 935 3319099 SGTC_3035 9091303 49.47 µM -1.0521132863217 0.139435185959426 no 2917 0.146373788545576 959 25237002 SGTC_2895 9054447 58.44 µM -1.05372184880986 0.13907445124824 no 2918 0.146005141389086 965 2697450 SGTC_1348 1493-0373 93.8 µM -1.05641368684499 0.138472204312673 no 2919 0.145389627797659 954 3010129 SGTC_1748 st037455 53.6035 µM -1.0569420237079 0.138354208068 no 2920 0.145269023912209 958 580690 SGTC_3189 9110682 49.47 µM -1.05770051369391 0.138184930368419 no 2921 0.145096000497004 975 17122418 SGTC_3286 9117135 37.221 µM -1.0588898389759 0.13791978445464 no 2922 0.14482497617414 930 3438150 SGTC_2044 5102272 200 µM -1.05947731719266 0.137788941316655 no 2923 0.144691227067025 948 592666 SGTC_1863 st057641 20.1 µM -1.06136105807834 0.137369965905203 no 2924 0.144262923604048 963 3921635 SGTC_587 k089-0003 57 µM -1.06367413050957 0.136856691061198 no 2925 0.143738173764449 911 9659696 SGTC_2947 9072639 7.68 µM -1.06394907207765 0.136795768324002 no 2926 0.143675885533348 981 16488146 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.06398238890613 0.136788387097172 no 2927 0.143668338816922 946 140250 A respiratory chain inhibitor. SGTC_230 MPP+ 141.667 µM -1.06492477270007 0.136579718023002 no 2928 0.143454986818803 953 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2047 4141938 200 µM -1.06814411164688 0.135868512558863 no 2929 0.142727755223764 950 3807862 SGTC_1555 citronellol 128 µM -1.06816227026483 0.135864508224117 no 2930 0.142723660369561 950 8842 A terpine precursor. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.0733988499414 0.134713109631099 no 2931 0.141546100156397 981 4620898 SGTC_1511 0906-3109 28.5 µM -1.07513002848332 0.134333941891054 no 2932 0.141158258506687 955 2882180 SGTC_2576 guaiol 23.12 µM -1.0762375013152 0.134091764713968 no 2933 0.140910525974637 916 227829 SGTC_1389 3405-0187 19 µM -1.07632242394973 0.134073206604208 no 2934 0.140891541664649 931 799890 SGTC_1409 3909-8004 61.9 µM -1.07651230574782 0.1340317181939 no 2935 0.140849100190052 943 2119279 SGTC_2558 carylophyllene oxide 100 µM -1.08030274876022 0.133205366932443 no 2936 0.140003693038054 961 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1802 st050112 57.9 µM -1.08273131007032 0.132677764785643 no 2937 0.139463851162527 949 4662563 SGTC_1791 st048313 56.1 µM -1.08711203948809 0.131729700395129 no 2938 0.138493648857717 908 1204976 SGTC_354 2783-3500 4.88 µM -1.0882072091243 0.13149341922753 no 2939 0.13825182144626 941 6740761 SGTC_805 3852-0218 479 µM -1.09137634715695 0.130811331428088 no 2940 0.137553657886668 947 6615355 SGTC_869 0564-0080 44.1 µM -1.09353828118527 0.130347427828951 no 2941 0.137078765370644 938 6843321 SGTC_3311 9131146 2.8755 µM -1.09379226034421 0.130293004269401 no 2942 0.137023049679396 949 4900406 YPR165W RHO1 SGTC_1112 tnp00069 1.16933 µM -1.09608208699618 0.129803041815486 no 2943 0.136521426500105 950 145826 SGTC_1414 3917-0015 5.4 µM -1.09689939261539 0.129628469342068 no 2944 0.136342687149811 951 6618702 SGTC_758 0868-0029 16 µM -1.09751636926922 0.129496793919678 no 2945 0.136207864516402 923 762687 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.09824856515388 0.12934064864053 no 2946 0.136047982428069 953 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3131 9127911 49.47 µM -1.09846763317522 0.129293956406932 no 2947 0.136000171774556 946 45595681 SGTC_192 3455-0609 60.9 µM -1.0992537327879 0.12912650304786 no 2948 0.13582870361515 954 3769639 SGTC_1343 1487-0095 224 µM -1.09958403618876 0.129056187363261 no 2949 0.135756700300513 960 4560101 YGL055W OLE1 SGTC_3241 9133421 49.47 µM -1.09991147272836 0.128986508192042 no 2950 0.13568534774427 988 17018221 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.10010638221414 0.128945043440552 no 2951 0.135642886705435 941 5282309 SGTC_2966 9084041 48.03 µM -1.10035868111032 0.128891383481389 no 2952 0.135587936900218 961 17741380 SGTC_143 4032-1194 15.74 µM -1.10063752682204 0.128832095457999 no 2953 0.135527223037471 954 1806963 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.10263362600507 0.128408238344402 no 2954 0.135093150708348 966 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3066 9117245 49.47 µM -1.10291304205044 0.128348983712943 no 2955 0.135032464963318 938 17176980 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.10493914000762 0.127919885221723 no 2956 0.134592980603297 961 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3027 9089541 49.47 µM -1.10497169924226 0.127912997790276 no 2957 0.134585926148792 958 9943819 SGTC_2910 7948405 25.97 µM -1.10577243564334 0.127743694764176 no 2958 0.134412514268708 902 2971328 SGTC_1956 st077085 54 µM -1.10844010258196 0.127180782912434 no 2959 0.133835896874384 957 24208685 SGTC_1318 1280-3875 124 µM -1.11074302923999 0.126696225865888 no 2960 0.13333948754395 962 373245 SGTC_2415 st077333 57.7 µM -1.11129934014488 0.126579365958118 no 2961 0.133219761669165 924 2766255 SGTC_2423 st077119 87.2 µM -1.11318316153363 0.126184203891833 no 2962 0.132814886478593 939 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2258 7960471 200 µM -1.1163927526058 0.125512922332172 no 2963 0.132127027191432 983 2974708 SGTC_1491 4138-0063 26.5 µM -1.11940383482393 0.124885428072689 no 2964 0.13148394785746 961 23883227 SGTC_1844 rapamycin 4 nM -1.12170968721342 0.12440638437335 no 2965 0.130992948173867 908 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2113 5491891 107.031 µM -1.12267117787917 0.124207013586933 no 2966 0.130788586639966 954 789979 SGTC_2785 7756463 72.73 µM -1.12605952388873 0.123506202065871 no 2967 0.130070162549035 960 2201551 SGTC_1208 2323-2347 50.3 µM -1.12792847837463 0.123120833576026 no 2968 0.129675062815947 955 5412760 SGTC_654 1124-0271 80.9 µM -1.12844400755384 0.123014682655575 no 2969 0.129566225606346 961 5403748 SGTC_378 3970-0959 8.33 µM -1.12866417491881 0.122969368273142 no 2970 0.129519763721027 979 6615653 SGTC_2962 9082311 13.18 µM -1.12974155083283 0.122747793790248 no 2971 0.129292571696781 954 16459453 SGTC_1149 3909-7961 23.3 µM -1.12991724692787 0.122711686483687 no 2972 0.12925554793186 957 735261 SGTC_1063 disulfiram 1.84 µM -1.13005217720957 0.122683962018006 no 2973 0.129227119579905 963 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_986 1493-0483 84 µM -1.13098222526558 0.122492982212982 no 2974 0.129031286402012 963 40079 SGTC_1213 1315-0166 115 µM -1.13522381651812 0.121624642312822 no 2975 0.128140776497678 947 768401 SGTC_182 3448-4371 550.524 µM -1.13661056688759 0.121341687002089 no 2976 0.127850560349987 937 3491403 SGTC_552 k242-0005 476 µM -1.13750473151876 0.121159485500294 no 2977 0.127663673876815 974 4088318 SGTC_629 3448-6466 76.7 µM -1.13810078849393 0.121038135533492 no 2978 0.127539199464746 963 573744 SGTC_41 0478-0632 82.643 µM -1.14049126705329 0.120552322321826 no 2979 0.127040844463376 943 3750424 SGTC_1783 st039459 87.517 µM -1.14110660577077 0.120427490513037 no 2980 0.126912781346726 980 729761 SGTC_1876 myriocin 605 nM -1.14362811974638 0.119916909986558 no 2981 0.126388947401367 953 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1381 2324-0066 62.1 µM -1.14380768108376 0.119880608963987 no 2982 0.126351701831376 966 10885928 SGTC_2301 7769476 200 µM -1.14845731511899 0.118943312130888 no 2983 0.125389912255077 964 977820 SGTC_633 0437-0093 97.7 µM -1.14927201344268 0.118779615397809 no 2984 0.125221917231575 965 2831118 SGTC_2376 9072922 81.32 µM -1.15001124641857 0.118631219631621 no 2985 0.12506961960665 977 17087968 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.1501217008244 0.118609057948547 no 2986 0.125046874777285 968 4213774 SGTC_2989 9073649 71.4286 µM -1.15014917506028 0.118603545944584 no 2987 0.125041217716889 958 21367202 SGTC_2614 arthonioic acid 13.39 µM -1.1533996791269 0.117952692342611 no 2988 0.124373186565786 984 6710684 SGTC_244 nsc-207895 1.295 µM -1.15345795538001 0.117941046697437 no 2989 0.124361232671145 931 42640 SGTC_2812 7970281 58.44 µM -1.15460738312517 0.117711516832287 no 2990 0.124125620933961 990 2233435 SGTC_2334 9017922 200 µM -1.15692832048256 0.11724901166488 no 2991 0.123650823482578 958 3163164 SGTC_225 nsc-122657 1.016 µM -1.15896220231329 0.116844769036359 no 2992 0.123235796146021 973 275685 SGTC_1012 4112-3522 18 µM -1.15955804081835 0.116726530932921 no 2993 0.123114396359172 950 3112398 SGTC_2907 7721985 69.9 µM -1.16173790413277 0.116294682133402 no 2994 0.122670972044961 962 3267881 SGTC_520 3584-0023 682 µM -1.16198254644301 0.116246287329585 no 2995 0.122621277306492 955 1340790 SGTC_584 0986-0246 15.4 µM -1.1664737938326 0.115360373353002 no 2996 0.121711469016792 991 53315 YDR232W HEM1 SGTC_1952 st077036 64.1 µM -1.16749166108113 0.11516026428071 no 2997 0.121505936978942 955 2937007 SGTC_2033 5192550 145 µM -1.16858300560014 0.114945984131904 no 2998 0.121285839265974 946 182073 SGTC_701 4424-0219 185 µM -1.16885661201086 0.114892307342332 no 2999 0.121230703473929 980 2911779 SGTC_2141 5621638 7.665 µM -1.17001891164681 0.114664483246955 no 3000 0.120996679183664 973 2856238 SGTC_922 1866-0035 480 µM -1.17572553551187 0.113550583229249 no 3001 0.119852285535519 949 3156169 SGTC_341 1486-1430 230 µM -1.17676985829724 0.113347575455551 no 3002 0.119643688138526 967 2054753 YPL210C SRP72 SGTC_1448 4255-0083 152 µM -1.17844516175402 0.113022451200172 no 3003 0.119309591133749 986 5399660 SGTC_2466 5983409 37.09 µM -1.18148182410607 0.112434827226097 no 3004 0.118705684880551 992 2879657 SGTC_2156 5649887 115 µM -1.1842736409204 0.111896511994223 no 3005 0.118152379772289 991 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2001 4023502 57.655 µM -1.18657791271231 0.111453595067373 no 3006 0.117697076194511 961 108941 YCR052W RSC6 SGTC_643 k048-0106 28.4 µM -1.18664843946502 0.111440058544338 no 3007 0.117683160348928 980 6763920 SGTC_3050 9093513 49.47 µM -1.18853994220439 0.111077452611354 no 3008 0.117310376618894 949 25236664 SGTC_824 1304-0008 100 µM -1.18860280198001 0.111065416754513 no 3009 0.117298002377868 975 768245 SGTC_2208 7283366 200 µM -1.19669862367084 0.109523095439631 no 3010 0.115712021847944 952 898663 SGTC_995 3931-2021 34.6 µM -1.19673386851332 0.109516414799346 no 3011 0.115705150805826 993 730143 SGTC_2034 5197015 53.07 µM -1.20069843204956 0.108766800851112 no 3012 0.114934101287703 980 780676 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.20256095426149 0.108415914488513 no 3013 0.114573132516846 989 15053 SGTC_666 0272-0154 136 µM -1.20349903112872 0.108239496002016 no 3014 0.114391633035665 994 6870312 SGTC_1813 st051246 8.6015 µM -1.20350788586973 0.108237831728979 no 3015 0.114389920792673 955 5291959 SGTC_1721 st082152 9.2685 µM -1.20462799794009 0.108027452074601 no 3016 0.114173471629431 970 5296051 SGTC_1005 4092-0690 4.4 µM -1.20478240923274 0.107998473624234 no 3017 0.114143656262564 985 1529343 SGTC_1902 st060212 70.5 µM -1.20644962867654 0.107685942091884 no 3018 0.113822085043358 951 688944 SGTC_1777 st045864 34.765 µM -1.20773411220581 0.107445601759053 no 3019 0.113574776158789 1005 4691462 SGTC_1716 st033144 30.6155 µM -1.20812913141937 0.107371767313062 no 3020 0.113498797957505 978 674617 SGTC_2011 4012611 177 µM -1.20989485214683 0.107042177296738 no 3021 0.11315962141071 984 2049887 SGTC_1481 3346-2004 36 µM -1.21662056649635 0.105793437475378 no 3022 0.111874307001796 988 2770522 SGTC_1590 st077108 57.8 µM -1.22168206611854 0.104860655110799 no 3023 0.11091394038285 963 5489485 SGTC_1178 0988-0033 191 µM -1.22422316178654 0.10439460887526 no 3024 0.110434026976348 967 5392207 SGTC_855 0428-0020 25 µM -1.2255878680637 0.104144937128493 no 3025 0.110176902773356 964 6812414 SGTC_1554 st069299 38.7 µM -1.22562495383455 0.104138158367976 no 3026 0.11016992144442 972 24207999 SGTC_2306 7482397 179.52 µM -1.22711582141456 0.103865913458359 no 3027 0.109889531064095 1005 891448 SGTC_482 fipronil 114 µM -1.23119756551264 0.103123194974561 no 3028 0.109124490862201 983 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_122 0236-0016 402.397 µM -1.23300528333242 0.102795495980182 no 3029 0.108786896510127 966 6808838 SGTC_1296 1068-0102 11.9 µM -1.23595903756278 0.10226167559505 no 3030 0.108236895114498 975 767053 SGTC_3022 9087993 49.47 µM -1.24020157179251 0.101498471226055 no 3031 0.107450423594043 991 17173644 SGTC_2079 5212404 121 µM -1.24176371448082 0.101218499470848 no 3032 0.107161877098102 983 758462 SGTC_933 2914-0560 114 µM -1.24374456841417 0.100864294822822 no 3033 0.106796793655272 970 463887 SGTC_2780 5215298 71.43 µM -1.24497503352904 0.100644725842486 no 3034 0.106570463824551 988 2834131 SGTC_2516 gossypol 71.55 µM -1.24621816147981 0.10042325150525 no 3035 0.106342156626095 990 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_347 4534-1311 26.2 µM -1.24830195787937 0.100052802634211 no 3036 0.105960248741301 986 2862016 SGTC_784 4579-0127 173 µM -1.2488581488697 0.099954094173835 no 3037 0.105858480595839 985 1948547 SGTC_1038 k292-0204 154 µM -1.25139442064945 0.0995048778505946 no 3038 0.105395305929429 978 4454212 SGTC_962 1254-0300 21.5 µM -1.2519460213029 0.0994073757642164 no 3039 0.105294766836775 969 7340576 SGTC_60 0986-0278 202 µM -1.25499551195587 0.098869601518006 no 3040 0.104740194604809 982 3110598 SGTC_96 0929-0093 37.281 µM -1.25590401381469 0.0987098005343176 no 3041 0.104575386570705 985 6991579 SGTC_392 N-ethylmaleimide 8.33 µM -1.25725883671533 0.0984718451566902 no 3042 0.104329962136538 968 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_671 0560-0003 407 µM -1.25790208442848 0.0983590149998391 no 3043 0.104213584887008 985 3238678 SGTC_150 3970-0969 77.2 µM -1.25955929499049 0.0980687648765177 no 3044 0.103914193668084 986 6615640 SGTC_2173 5763948 167 µM -1.26107003417493 0.0978047155662658 no 3045 0.103641807898502 988 2867177 SGTC_3337 9144342 33.5465 µM -1.26182710537109 0.0976725896901958 no 3046 0.103505503237705 979 17682949 SGTC_3225 9130819 49.47 µM -1.26749072908167 0.0966883100484455 no 3047 0.102489938247421 982 4547121 SGTC_1790 st045711 43.5 µM -1.26852583707696 0.0965092090839313 no 3048 0.102305114984205 931 585119 SGTC_99 0109-0120 622.8 µM -1.26888269780545 0.0964475193085359 no 3049 0.102241452095347 977 759414 SGTC_102 gallobenzophenone 83.616 µM -1.27509727649404 0.0953778596119305 no 3050 0.101137406628518 971 70837 SGTC_2566 crystal violet carbinol 226 nM -1.2771824769597 0.0950209167097218 no 3051 0.100768915968857 986 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2070 5230947 200 µM -1.27793831451186 0.0948917763360203 no 3052 0.100635588579922 1009 2835538 SGTC_2708 st078559 56 µM -1.28083750654284 0.0943976274063474 no 3053 0.100125373509173 957 17250902 SGTC_1780 st038448 24.544 µM -1.28129899014164 0.094319145830721 no 3054 0.100044333736206 999 728868 YDL195W SEC31 SGTC_274 sirtinol 40.1 µM -1.28144423171925 0.094294455479629 no 3055 0.100018838202876 982 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_554 4483-2211 187 µM -1.28197135864618 0.0942048865498513 no 3056 0.0999263468270629 1004 747107 SGTC_2367 9070478 135.38 µM -1.28565240652004 0.0935811550259807 no 3057 0.099282199095408 984 572802 SGTC_834 0312-0008 75.7 µM -1.28898259597369 0.0930195065705921 no 3058 0.0987020686000027 1007 6385573 YIL048W NEO1 SGTC_309 k408-0051 1.48 µM -1.29045873386634 0.092771349136557 no 3059 0.0984457153812432 965 3640463 SGTC_113 0099-0221 2.5 µM -1.2916785433666 0.0925666534546968 no 3060 0.0982342455446934 980 89219 SGTC_79 0052-0007 94.094 µM -1.29200667121942 0.0925116475370573 no 3061 0.0981774171483502 958 2801472 SGTC_617 3770-0098 35 µM -1.29254024202311 0.0924222537011954 no 3062 0.0980850595566705 985 5962639 SGTC_3167 9103034 49.47 µM -1.29281856851314 0.0923756485768941 no 3063 0.0980369083453241 1005 5127859 SGTC_850 0388-0143 75.9 µM -1.29281885686378 0.0923756003022673 no 3064 0.0980368584688902 1001 67273 SGTC_2151 5563267 85.4165 µM -1.29752056437329 0.0915909370096707 no 3065 0.0972260670566896 1018 5310824 SGTC_2929 9013348 24.6 µM -1.30060666126477 0.0910785930074877 no 3066 0.0966965628900023 990 2995952 SGTC_3239 9133757 49.47 µM -1.30087012562446 0.0910349521689222 no 3067 0.0966514567045783 1022 17036923 SGTC_619 1652-1634 108 µM -1.3033544983267 0.0906241974569756 no 3068 0.0962268816139211 1006 5400454 SGTC_469 w7 172 µM -1.30641656754844 0.0901198237605748 no 3069 0.0957054673818692 989 45115570 A P450 inhibitor. SGTC_1837 st055472 66.5 µM -1.30831949547334 0.0898074323621445 no 3070 0.0953824826730415 996 676091 SGTC_1602 st001878 87.6 µM -1.30932854926876 0.0896421094360161 no 3071 0.0952115414673883 992 595405 YLR310C CDC25 SGTC_1497 4476-2978 41.3 µM -1.31062094698263 0.089430694222696 no 3072 0.0949929293379074 970 1528379 SGTC_2865 9030313 51.95 µM -1.31102749593461 0.0893642661784392 no 3073 0.0949242371316482 996 42562754 SGTC_1922 5578187 25 µM -1.31432758956082 0.0888264052638248 no 3074 0.0943679932979442 944 1350412 SGTC_1519 esterone 74 µM -1.31506805168698 0.0887060539111278 no 3075 0.094243516319121 1003 698 A steroid. SGTC_123 0083-0120 66.675 µM -1.31659300516446 0.0884585775585188 no 3076 0.0939875423567288 1021 16001701 SGTC_906 1165-0455 526 µM -1.31811508829189 0.0882120803422404 no 3077 0.0937325621682916 996 3252859 SGTC_1009 4106-0057 9.87 µM -1.31823074607895 0.0881933708300352 no 3078 0.0937132080105488 989 2928005 SGTC_1129 3453-1384 223 µM -1.32168861590212 0.0876353699623466 no 3079 0.0931359305160167 1003 1084452 SGTC_2961 9083290 32.55 µM -1.32424722849375 0.0872241821308127 no 3080 0.092710475150322 1004 17741490 SGTC_245 methotrexate 289.6 µM -1.32425997371889 0.0872221374915309 no 3081 0.0927083594320379 978 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_974 1326-0144 138 µM -1.32923439512872 0.08642685107851 no 3082 0.0918853254022757 1008 5411856 SGTC_820 1582-0060 59.9 µM -1.33095849889974 0.0861524787555859 no 3083 0.0916013334432984 996 3848840 SGTC_59 0330-0160 1.33 µM -1.33142853302202 0.0860777911012914 no 3084 0.0915240230285476 995 4293482 SGTC_1784 st039334 36.3 µM -1.33239728133523 0.0859240113987615 no 3085 0.0913648375044293 985 3496984 SGTC_786 4544-0069 423 µM -1.33448658905462 0.0855930534113906 no 3086 0.0910222195584001 976 748821 YLR208W SEC13 SGTC_305 1682-2595 20.8 µM -1.33469171258123 0.0855606122290758 no 3087 0.090988633544279 989 226033 SGTC_7 0192-1582 4.227 µM -1.33531490141304 0.0854621086708671 no 3088 0.0908866517675008 1024 252616 SGTC_870 0573-2213 57.6 µM -1.33726017833334 0.0851551772751644 no 3089 0.0905688623299319 998 3916321 SGTC_778 3456-2434 196 µM -1.33862007045581 0.0849411006530453 no 3090 0.090347194434935 898 5539063 SGTC_836 0330-0104 1.35 µM -1.34205326326666 0.0844024366312327 no 3091 0.0897893631145086 971 46494820 SGTC_2160 5660466 132.927 µM -1.3433945566542 0.0841926869583745 no 3092 0.0895721242687811 1007 2859134 SGTC_3339 9145883 14.936 µM -1.34425727490223 0.0840579831376127 no 3093 0.0894326032023195 959 2030670 SGTC_1091 telmisartan 47.6 µM -1.34741739714176 0.0835659470626195 no 3094 0.0889229203235014 1011 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2881 9058953 51.95 µM -1.34744631311535 0.0835614548130777 no 3095 0.088918266592207 973 17122249 SGTC_269 exalamide 29 µM -1.34933213367863 0.0832688742750079 no 3096 0.0886151543551088 1007 3316 A derivative of salicylamide. SGTC_2439 5492030 7.2 µM -1.35292611237648 0.0827134107123708 no 3097 0.0880396181725297 970 5722370 SGTC_757 1066-0008 322 µM -1.3546251126016 0.0824517962210858 no 3098 0.0877685141439179 977 6842497 SGTC_25 0118-0223 35.662 µM -1.3565549973752 0.0821553860681223 no 3099 0.087461324596455 1007 5333628 SGTC_1656 st012921 11 µM -1.3645607949859 0.0809343461750798 no 3100 0.0861955670095621 998 6732821 SGTC_2228 7354201 200 µM -1.3667735729681 0.0805992830542395 no 3101 0.0858481442987823 1024 753451 SGTC_692 k241-0027 77.8 µM -1.37013641351382 0.0800920827669954 no 3102 0.0853221614317375 994 3600480 SGTC_1002 4049-0206 172 µM -1.37022536044455 0.0800787001794851 no 3103 0.0853082820620363 991 4662749 SGTC_98 0074-0023 107.663 µM -1.37145590570197 0.0798937308558338 no 3104 0.0851164400555317 1008 3563821 SGTC_621 3584-0052 32.1 µM -1.37479703393525 0.0793931391160538 no 3105 0.0845971889712494 1006 2273927 SGTC_1085 doxorubicin 7.67 µM -1.37588347965656 0.0792308725982646 no 3106 0.0844288553348946 989 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2159 5658611 73.75 µM -1.37731478529668 0.0790174828470741 no 3107 0.0842074729844441 1000 793844 SGTC_1244 0416-0015 52.5 µM -1.37838610005518 0.0788580482714368 no 3108 0.0840420563236225 1006 96201 SGTC_1340 1486-1359 257 µM -1.37872312207441 0.0788079426061862 no 3109 0.0839900688223062 982 4309068 SGTC_2455 5377712 9.75 µM -1.37910112657743 0.0787517727056961 no 3110 0.0839317882817086 981 2243908 SGTC_1021 4476-0760 85.3 µM -1.38442973054938 0.0779631889414514 no 3111 0.0831134553533759 1015 746768 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.38685751387185 0.0776058926642863 no 3112 0.0827426076497804 1004 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1781 st038725 66.3 µM -1.38727378239531 0.0775447555835232 no 3113 0.0826791472263549 1012 4270275 YIL048W NEO1 SGTC_107 0358-0022 2.6945 µM -1.3878788334921 0.0774559573525358 no 3114 0.0825869720932928 1025 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_291 SEC14.278 35.5 µM -1.38836259679134 0.0773850150779622 no 3115 0.08251332993594 1005 1068044 SGTC_1454 4239-0054 42.6 µM -1.38945639654941 0.0772247949473305 no 3116 0.0823470056108462 1005 1340767 SGTC_2665 lovastatin 100 µM -1.39205336889459 0.0768453993113693 no 3117 0.0819531187470821 1016 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_33 0986-0033 35.816 µM -1.39555798747642 0.0763356529093024 no 3118 0.0814238206480682 968 2848082 SGTC_704 1310-0270 142 µM -1.39665456961945 0.0761766847962627 no 3119 0.081258735956781 1010 5718033 SGTC_558 k064-0027 21.3 µM -1.39777122659835 0.0760150655609069 no 3120 0.0810908887242642 999 5088526 SGTC_2683 piperine 63.03 µM -1.39907012548574 0.0758273981668534 no 3121 0.0808959776324443 1016 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1393 3470-5649 58.2 µM -1.40355369447257 0.0751823142146563 no 3122 0.0802258960990977 998 4108395 SGTC_474 dl-dihydrosphingosine 5 µM -1.40451150247787 0.0750450513493756 no 3123 0.0800832944487739 984 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1154 4088-0362 150 µM -1.4056150989216 0.0748871327013554 no 3124 0.0799192250179918 1012 6618304 SGTC_2663 amphotericin b 100 µM -1.40583794054769 0.0748552760613063 no 3125 0.0798861264748714 1004 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_744 1594-0068 283 µM -1.40873121935069 0.0744426012712693 no 3126 0.0794573299367957 1023 668392 SGTC_1153 4055-0057 267 µM -1.40897276521664 0.0744082277576512 no 3127 0.0794216107182956 997 882706 SGTC_215 1287-0124 461.5 µM -1.40987563886704 0.0742798503895826 no 3128 0.0792882035548216 1023 5560863 SGTC_1474 0330-0125 5.35 µM -1.41022851691528 0.0742297215319905 no 3129 0.0792361089929014 1034 X1474 SGTC_1917 st066507 28.5 µM -1.41306490451178 0.073827730360022 no 3130 0.0788183205737527 997 3156428 SGTC_228 caffeine 993.056 µM -1.42229639539533 0.0725308993846793 no 3131 0.0774701124417413 1005 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2365 9042475 200 µM -1.4266326517413 0.071927802013127 no 3132 0.0768429037384532 995 6464479 SGTC_979 1426-2828 121 µM -1.43252279555602 0.0711147547690248 no 3133 0.0759971295268226 1029 747872 SGTC_774 k060-0086 136 µM -1.43468782041235 0.0708176852878309 no 3134 0.0756880382261466 1024 5911235 SGTC_3174 9107204 49.47 µM -1.43665311202976 0.0705488481836112 no 3135 0.0754082920403201 1024 3938802 SGTC_1853 st056710 91.2 µM -1.44294726255976 0.0696931335464105 no 3136 0.0745176639421388 1017 269167 SGTC_174 3553-0389 74.3 µM -1.44469564017855 0.0694568584208367 no 3137 0.0742716975337947 1019 738071 SGTC_1197 1601-0112 267 µM -1.44921185816071 0.0688493932334927 no 3138 0.0736392134773441 1027 7350313 SGTC_2582 agaric acid 100 µM -1.4496679256918 0.0687882771394023 no 3139 0.0735755720666996 998 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2205 7238770 200 µM -1.45310631575194 0.0683288555646827 no 3140 0.0730971188861474 1014 279867 SGTC_1660 st012960 28.1 µM -1.45341923281663 0.0682871628779925 no 3141 0.0730536948414851 1011 24207266 SGTC_2069 5228469 200 µM -1.4539967097499 0.0682102721082125 no 3142 0.0729736092025675 1022 2835210 SGTC_1661 st013063 9.66 µM -1.45476524272883 0.068108045982896 no 3143 0.072867131781102 1017 721395 SGTC_1831 st055328 12 µM -1.45812467838693 0.0676625797903255 no 3144 0.0724030901304986 1009 1103068 SGTC_603 3794-0023 45.9 µM -1.46003607767947 0.0674101319767664 no 3145 0.0721400794266033 1028 3802260 SGTC_2583 asiatic acid 100 µM -1.46026700183707 0.0673796820515371 no 3146 0.0721083536483573 1021 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_929 2805-0021 398 µM -1.46556645312791 0.066683808014468 no 3147 0.0713832180356916 1030 3098024 SGTC_3142 9086498 49.47 µM -1.46905726734349 0.0662284742665054 no 3148 0.070908628501358 977 25236367 SGTC_2653 dihydrofissinolide 100 µM -1.47020372775898 0.0660794590746819 no 3149 0.0707532927043417 1038 6857746 SGTC_1774 st048371 48.465 µM -1.47216792620371 0.0658247594338494 no 3150 0.0704877681525665 1020 4242727 SGTC_2226 7298446 200 µM -1.47625800787765 0.0652968368224632 no 3151 0.0699373212124944 1034 3283010 SGTC_1477 0139-0234 16 µM -1.4770888588849 0.0651899981718182 no 3152 0.0698259097996152 1033 620880 SGTC_1607 st000305 50.6 µM -1.48108483163248 0.0646780522607448 no 3153 0.0692919846665332 1015 5457690 SGTC_806 3966-4455 5.86 µM -1.48451027197436 0.0642416906437221 no 3154 0.0688368000567613 1016 714982 SGTC_1243 0416-0003 5.65 µM -1.48477019575864 0.0642086729772092 no 3155 0.0688023547894747 1015 2141977 SGTC_983 1491-0821 12.2 µM -1.48538646818613 0.0641304416739314 no 3156 0.0687207390786538 1013 46495113 SGTC_2040 5100729 123 µM -1.48854316722852 0.0637308829782506 no 3157 0.0683038534389637 1033 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1878 temozolomide 1 mM -1.49126667730313 0.0633877136670959 no 3158 0.067945746984493 1002 5394 DNA alkylating agent. SGTC_8 0354-0001 70 µM -1.49326350308915 0.0631370236452018 no 3159 0.067684112557474 1029 4993152 SGTC_2126 5251174 33.877 µM -1.49371652303317 0.0630802571854406 no 3160 0.0676248640008587 1025 790722 SGTC_1120 ficusin 1.78878 µM -1.50100155079441 0.0621728434066229 no 3161 0.0666775802306278 1026 6199 A DNA cross-linker. SGTC_3102 9121669 49.47 µM -1.50273694045647 0.0619581944807709 no 3162 0.0664534464149011 1048 41905072 SGTC_872 0588-0139 234 µM -1.50311591020549 0.0619113970477712 no 3163 0.0664045783585651 1026 2047100 SGTC_2253 7938677 135.83 µM -1.50317105049234 0.061904590297513 no 3164 0.0663974703514343 1038 2301972 SGTC_1173 0443-0020 122 µM -1.50724518797101 0.0614032754738869 no 3165 0.0658739107149416 1031 5331295 SGTC_463 ikarugamyin 104 µM -1.51301763766671 0.0606984231901145 no 3166 0.0651375893730059 1055 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1880 MG-132 525 µM -1.51516053615991 0.0604383783581254 no 3167 0.0648658771615095 997 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_639 0833-0042 114 µM -1.51900553883098 0.0599739662765502 no 3168 0.0643805508976086 1030 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3356 9151811 4.48 µM -1.52303987851737 0.0594896948195977 no 3169 0.0638743643673492 1030 1859254 YPR165W RHO1 SGTC_1314 1222-0010 41.1 µM -1.52615007503616 0.0591184516068191 no 3170 0.0634862468119806 1036 3526027 SGTC_1015 4130-4525 82 µM -1.52678819978758 0.059042508084952 no 3171 0.0634068434051117 1021 1363237 SGTC_3272 9137413 49.47 µM -1.52738625030779 0.0589714033065834 no 3172 0.0633324967247935 1022 17614870 SGTC_2060 5238662 140 µM -1.52841314676534 0.058849467940705 no 3173 0.063204996367668 1033 790130 SGTC_2680 butyl paraben 22.24 µM -1.53126903032203 0.0585113957633659 no 3174 0.0628514581487023 1054 7184 An antifungal and steroid mimetic. SGTC_611 3453-1652 23.7 µM -1.53425796556896 0.0581592083894228 no 3175 0.0624831011780201 1037 1560575 SGTC_189 3970-0742 2.116 µM -1.53481201285178 0.0580941081486621 no 3176 0.0624150055713109 1018 2891807 SGTC_895 0964-0006 13.7 µM -1.53485782981061 0.0580887272464089 no 3177 0.0624093769943408 1029 6738897 SGTC_1207 2099-0101 141 µM -1.53734476653248 0.0577972399201382 no 3178 0.0621044521854561 1017 5837381 SGTC_2981 9013952 38.96 µM -1.54868827268702 0.0564822570489722 no 3179 0.0607283371798331 1016 2996344 SGTC_1901 st060216 58.6 µM -1.5511373976681 0.0562014637548886 no 3180 0.060434380323886 1013 688792 SGTC_1914 st062367 72.6 µM -1.5529388483021 0.0559956300304343 no 3181 0.060218872327127 1009 978205 SGTC_1357 1503-1303 39.5 µM -1.55805629004648 0.0554141539506679 no 3182 0.0596099525039503 1017 292895 SGTC_1951 sophoraflavanone G 9.2 µM -1.56011516384718 0.0551815609298841 no 3183 0.0593663343684054 1009 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1237 0330-0133 46.1 µM -1.5658999336276 0.0545321756652084 no 3184 0.0586860227041513 1025 X1237 YHR072W ERG7 SGTC_646 4092-0839 27.3 µM -1.5685005579747 0.0542422116086212 no 3185 0.0583821799229293 1023 877796 SGTC_1982 st072467 71.9 µM -1.56971049807695 0.054107722364715 no 3186 0.0582412388878438 1027 3163533 SGTC_648 0375-0473 33.3 µM -1.58465354264072 0.0524684175375033 no 3187 0.0565225363142174 1032 1713139 SGTC_2370 9071495 200 µM -1.5878911248897 0.0521184932267794 no 3188 0.0561554803669308 1037 21791103 SGTC_270 tamoxifen 5.46 µM -1.59278554865846 0.0515930165225958 no 3189 0.0556041540778252 1064 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1282 0886-0010 32.4 µM -1.59369235964803 0.0514961233063632 no 3190 0.0555024781705927 1008 2836211 YNL267W PIK1 SGTC_479 n-linoleoylglycine 10 µM -1.59546394001911 0.0513072465828985 no 3191 0.0553042637805736 1037 6433346 An anti-infammatory. SGTC_1136 pergolide 1.05886 µM -1.59669239550674 0.0511765988897031 no 3192 0.0551671457950381 1025 47811 A dopamine receptor agonist. SGTC_3211 9128781 49.47 µM -1.59792559469416 0.0510457130838915 no 3193 0.0550297685727656 1008 17194361 SGTC_1836 st055642 81 µM -1.59807350333527 0.0510300326844678 no 3194 0.0550133098601012 1031 8571 SGTC_328 k915-0120 63.5 µM -1.60260086068256 0.0505519209648829 no 3195 0.0545114018113148 1031 6624543 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.60331681954878 0.0504766399425543 no 3196 0.0544323624719898 1027 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2332 7982454 138.89 µM -1.61179430465959 0.0495920305740834 no 3197 0.0535033539744039 1042 2981748 SGTC_948 3448-0295 75.3 µM -1.61695501317214 0.0490596071590896 no 3198 0.0529439960081289 1015 678569 SGTC_1717 st033143 58.0435 µM -1.61901165198939 0.0488487030574905 no 3199 0.0527223780463002 1030 674616 SGTC_2959 9079155 11 µM -1.630124847178 0.0477215733512579 no 3200 0.0515375566280298 1042 16189457 SGTC_3228 9131799 49.47 µM -1.63021015821417 0.047713002125307 no 3201 0.0515285438599221 1054 17015818 SGTC_3088 9117578 49.47 µM -1.63049731695544 0.0476841602570523 no 3202 0.0514982159021455 1060 678341 SGTC_44 0929-0055 61.211 µM -1.63456604228457 0.0472770011145519 no 3203 0.0510700255625818 1004 1379590 SGTC_1703 st026983 48.3 µM -1.63745838531438 0.0469892610649136 no 3204 0.0507673636873948 1021 1104023 SGTC_214 4373-3496 70 µM -1.64111812756659 0.046627192056517 no 3205 0.0503864482445974 1041 3779166 SGTC_3333 9141820 12.094 µM -1.64287823477328 0.0464538585087048 no 3206 0.0502040645515805 1017 1939433 SGTC_1035 k081-0041 55.2 µM -1.64344632237592 0.0463980243632997 no 3207 0.0501453113298423 1044 731709 SGTC_2018 5133068 143 µM -1.65256119468919 0.0455095200185034 no 3208 0.0492101005926364 1030 785362 SGTC_2154 5570129 200 µM -1.65670071600343 0.0451105486695383 no 3209 0.0487899990946646 1064 673366 SGTC_1990 st072050 59.8 µM -1.66704887465779 0.044125487905233 no 3210 0.0477523434237166 1036 17233948 SGTC_722 3534-0461 190 µM -1.67098648072682 0.0437552451314957 no 3211 0.0473621740887653 1033 658262 SGTC_1649 st011737 51.3 µM -1.67829649488461 0.0430745514681294 no 3212 0.0466446159905166 1004 1761035 SGTC_20 0481-0013 4.944 µM -1.68287772012811 0.0426523352555118 no 3213 0.0461993827365909 1031 182045 SGTC_1226 3909-7979 35.4 µM -1.69045758038421 0.041961111202049 no 3214 0.0454702235693427 1031 6615510 SGTC_73 0327-0325 16.231 µM -1.69388156267686 0.0416518582713712 no 3215 0.0451438955684163 970 53298 SGTC_75 0159-0059 199.013 µM -1.6979325294721 0.0412883633711338 no 3216 0.0447602484216093 1045 5377270 SGTC_1193 1488-0126 41.5 µM -1.70019672301673 0.0410863192724517 no 3217 0.0445469642338356 1037 1384710 SGTC_724 3910-0327 137 µM -1.70230296258082 0.040899090636052 no 3218 0.0443492948725292 1051 2885483 SGTC_2979 9012552 45.46 µM -1.70427405104955 0.040724503405877 no 3219 0.04416495022367 1050 17100905 SGTC_2682 pyrogallin 40.03 µM -1.70496535563865 0.0406634152164363 no 3220 0.0441004429582568 1039 822798 An ATP competetive kinase inhibitor. SGTC_1377 2944-0135 198 µM -1.70536678472619 0.040627976464335 no 3221 0.0440630195381272 1020 1894137 SGTC_1683 st010134 710 nM -1.70639013458034 0.0405377470274863 no 3222 0.0439677330911271 1044 3818134 SGTC_1053 3366-3204 134 µM -1.70650716909948 0.0405274383898769 no 3223 0.043956846336332 1047 3632071 YPR165W RHO1 SGTC_1993 st073995 70.8 µM -1.71359075408375 0.0399074535442827 no 3224 0.0433019564057509 1047 3098394 SGTC_533 1222-0222 6.71 µM -1.71592801600659 0.0397045861177316 no 3225 0.0430876091395743 1051 3982874 SGTC_644 1498-1197 63.3 µM -1.72037023495954 0.0393213262451789 no 3226 0.0426825819669066 1057 6741615 SGTC_64 000l-0018 272.079 µM -1.724628952201 0.0389567299609391 no 3227 0.0422971811771383 1021 6811119 SGTC_2750 bromebric acid 70.15 µM -1.72519450893873 0.038908519377671 no 3228 0.0422462124691019 1045 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3247 9135149 49.47 µM -1.72670257715713 0.0387802023829645 no 3229 0.0421105462967868 1030 8934436 YOR116C RPO31 SGTC_809 3998-0021 90 µM -1.72833865026323 0.0386413838931023 no 3230 0.0419637637592844 1037 715485 SGTC_2165 5727197 32.143 µM -1.72944296981088 0.0385479130191892 no 3231 0.0418649225632619 1050 1361712 SGTC_2956 9076196 2.52 µM -1.72955072819046 0.038538802101729 no 3232 0.0418552878428148 1062 16423868 SGTC_2327 6189656 200 µM -1.73038927218344 0.0384679635711436 no 3233 0.041780374615801 1042 5349088 SGTC_2479 5617353 43.85 µM -1.73143156527536 0.0383800607023743 no 3234 0.0416874104059003 1039 2731746 SGTC_1405 3909-7894 12 µM -1.73547480518123 0.0380406182816098 no 3235 0.0413283701677511 1009 7104060 SGTC_1557 sumaresinolic acid 42.3 µM -1.74949399854542 0.0368825844854777 no 3236 0.0401028326454314 1040 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_81 0411-0046 9.971 µM -1.75002576713665 0.0368392323257561 no 3237 0.0400569337944757 1034 12925265 SGTC_1320 1313-0481 95.3 µM -1.7535776931243 0.0365507309326317 no 3238 0.039751448032905 1044 6813365 YLR208W SEC13 SGTC_1166 k206-0078 225 µM -1.758375614065 0.0361639625476082 no 3239 0.0393418097936598 1041 5404595 SGTC_2492 derrusnin 100 µM -1.75851383907826 0.0361528698536184 no 3240 0.0393300594741986 1050 1715307 Part of coumarin class of compounds. SGTC_748 act1.228 77.9 µM -1.76476505892885 0.0356541081208261 no 3241 0.0388016296480459 1045 4421505 YNR035C ARC35 SGTC_2242 6630449 61.2675 µM -1.7686377279899 0.0353479612684591 no 3242 0.038477175211934 1050 691249 YDR170C SEC7 SGTC_1680 diphenhydramine 100 µM -1.76977436029363 0.0352585172105062 no 3243 0.0383823683663012 1028 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1665 st014639 11.4 µM -1.7766861115697 0.0347186055637998 no 3244 0.0378099493175973 1062 981133 YIL048W NEO1 SGTC_971 1315-0384 26.7 µM -1.78099185731609 0.0343857074751606 no 3245 0.0374568904869239 1058 6769120 SGTC_313 3474-0040 5.03 µM -1.78570853493545 0.0340240532976244 no 3246 0.0370732313617884 1063 1043375 YIL048W NEO1 SGTC_2806 7952793 58.44 µM -1.80465200607256 0.0326029261274818 no 3247 0.0355645772461346 1036 2972490 SGTC_1734 st037168 69.4 µM -1.81017255031414 0.0321981133588753 no 3248 0.0351345164855345 1050 708907 SGTC_481 bay k-8644 50 µM -1.81574918749951 0.0317934088094744 no 3249 0.0347044275162116 1053 2303 A calcium channel antagonist. SGTC_1775 st081588 35.1725 µM -1.81850352409923 0.0315950783601527 no 3250 0.0344936042899909 1024 1426443 YGL099W LSG1 SGTC_1591 genipin 88.4 µM -1.82147483611679 0.0313822718905457 no 3251 0.0342673542180448 1057 442424 A DNA cross-linking agent. SGTC_1151 3909-8316 15.3 µM -1.82165363799323 0.0313695039295742 no 3252 0.0342537783787237 1052 800431 SGTC_802 4112-3352 742 µM -1.82223001688318 0.0313283748557422 no 3253 0.0342100459139578 1045 704594 SGTC_2371 9071574 200 µM -1.82559676760265 0.0310890213254166 no 3254 0.033955511534159 1067 45596039 SGTC_2636 apigenin dimethyl ether 100 µM -1.82961070914066 0.0308056360606226 no 3255 0.033654085611421 1052 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_561 1550-0330 72.9 µM -1.83195426247516 0.0306411716560568 no 3256 0.0334791175719945 1061 6812934 SGTC_226 1,3-diallylurea 8.28947 mM -1.83955361671973 0.0301128634592238 no 3257 0.0329168996922998 1052 74537 YKL182W FAS1 SGTC_1272 0839-0021 27 µM -1.84130129251839 0.0299924388712134 no 3258 0.0327887092188214 1059 5027250 SGTC_513 4245-1575 41.7 µM -1.84449883731484 0.0297731440298257 no 3259 0.0325552375572099 1028 719745 SGTC_1490 4089-0339 670 nM -1.84896785300946 0.0294688792244096 no 3260 0.0322312273855144 1059 742542 SGTC_1636 st007707 68.9 µM -1.85245957309549 0.0292329521081316 no 3261 0.0319799287964352 1052 403051 SGTC_3046 9092212 49.47 µM -1.85640901506584 0.028967990841453 no 3262 0.0316976403660672 1066 25236637 SGTC_1531 st059297 52.4 µM -1.86684937619567 0.0282771627061342 no 3263 0.0309613125028689 1055 7566702 SGTC_301 4119-0100 24.5 µM -1.88975451634437 0.0268095086450913 no 3264 0.0293953996087815 1067 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1444 4112-3581 28 µM -1.89065027790736 0.0267534296747583 no 3265 0.0293355219615975 1059 2877249 SGTC_1805 st050013 60.3 µM -1.89198785644742 0.0266698732178541 no 3266 0.0292462993990854 1055 4037144 SGTC_1269 0831-0796 3.05 µM -1.89831602804678 0.0262775116770329 no 3267 0.0288272319113613 1020 927758 SGTC_1337 1486-1011 40.3 µM -1.90909155128957 0.0256205112969362 no 3268 0.028125141225927 1059 X1337 SGTC_1286 0929-0070 131 µM -1.91062062053498 0.0255284053541798 no 3269 0.028026676233004 1061 1420408 SGTC_2420 aureobasidin a 50 nM -1.91599708695124 0.0252067439500141 no 3270 0.0276827332405622 1058 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_472 calcifediol 10 µM -1.93980608702851 0.0238228468518493 no 3271 0.026201630311491 1074 5283731 A vitamin D metabolite. SGTC_172 1112-0046 2.638 µM -1.94150042103987 0.0237268467160542 no 3272 0.026098804202383 1072 2802135 YIL048W NEO1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.95387433748819 0.0230355628138575 no 3273 0.0253580400820443 1064 688761 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.95838513265942 0.0227878167475627 no 3274 0.0250924189912114 1042 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1302 1159-0335 255 µM -1.96247727549583 0.0225650103624999 no 3275 0.0248534718812008 1067 649284 SGTC_2784 7567673 72.73 µM -1.96472830417805 0.0224432327751136 no 3276 0.024722846088083 1044 3471247 SGTC_523 1934-0222 13.7 µM -1.97199713102669 0.022053777197705 no 3277 0.0243049670159666 1067 1361595 SGTC_2864 9034755 47.6 µM -1.98002010168539 0.0216305541550861 no 3278 0.0238506349881409 1054 4930451 SGTC_730 1436-0052 41.2 µM -1.98907746170444 0.0211610329273119 no 3279 0.0233463268102655 1068 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1228 0124-0032 52.5 µM -1.98915696974961 0.0211569498177983 no 3280 0.0233419398962059 1062 X1228 SGTC_27 0485-0001 32.618 µM -1.99094537262517 0.0210652829239291 no 3281 0.0232434466202359 1052 2054479 SGTC_1105 epirubicin 18.1 µM -1.99836939178997 0.0206883401828908 no 3282 0.0228383137341866 1059 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_159 3970-0959 50 µM -1.99867451810923 0.0206729708863932 no 3283 0.0228217909162874 1055 6615653 SGTC_3097 9117246 49.47 µM -1.99890913372623 0.02066115981071 no 3284 0.0228090931563551 1066 16423892 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.99919837948402 0.0206466063982958 no 3285 0.0227934469228708 1052 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_324 1315-0088 19.6 µM -2.01118616781675 0.020051031557685 no 3286 0.0221528981292092 1070 6787421 SGTC_1498 4478-3555 97.6 µM -2.0239853558079 0.0194312945153015 no 3287 0.0214858292666938 1073 3437919 SGTC_2231 micatex 6.853 µM -2.02706742420312 0.0192845157646022 no 3288 0.0213277588950505 1077 20737 An antifungal of unknown mechanism. SGTC_2321 7390090 138.78 µM -2.0301448485096 0.0191388993780514 no 3289 0.0211709089585445 1061 649046 SGTC_2697 mebhydrolin 72.4 µM -2.03916864963759 0.0187172928145725 no 3290 0.0207165993095199 1070 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_416 estradiol valerate 100 µM -2.0412127527984 0.0186228948339632 no 3291 0.0206148423328446 1074 13791 A steroid. SGTC_1126 isoteolin 1.0172 µM -2.0420759126723 0.0185831554331911 no 3292 0.0205720008995463 1063 133323 SGTC_2467 5474540 200 µM -2.04230433644147 0.0185726510186212 no 3293 0.0205606761136952 1051 5413519 SGTC_1756 st041558 35.5 µM -2.05019771872954 0.0182127548902798 no 3294 0.0201725702646747 1063 3955792 SGTC_1762 st045503 25.4615 µM -2.05053409172586 0.0181975510260594 no 3295 0.0201561702543962 1076 4645554 SGTC_459 nigericin 15.3 µM -2.05385672316648 0.0180479502383323 no 3296 0.0199947804959298 1069 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_58 0957-0393 9 µM -2.06184825566821 0.0176924210630978 no 3297 0.0196110925953344 1062 6997992 SGTC_409 arachidonic acid 100 µM -2.06577520416327 0.017519919189697 no 3298 0.0194248552199748 1061 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2936 9038235 15.59 µM -2.06617662136263 0.0175023670109135 no 3299 0.0194059027448478 1050 4749415 SGTC_1479 0549-0158 134 µM -2.06702318690331 0.0174653996970305 no 3300 0.0193659845749297 1076 5440202 SGTC_3229 9132204 49.47 µM -2.07423842676858 0.0171530257570274 no 3301 0.0190285865403884 1082 17682924 SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.07598089710898 0.0170783076276839 no 3302 0.0189478589058799 1063 165506 SGTC_480 am 92016 50 µM -2.09757777884758 0.0161750732501718 no 3303 0.0179712298763156 1075 2129 K+ channel blocker. SGTC_2517 totarol 10 µM -2.10562976211302 0.0158489545371422 no 3304 0.0176182626528542 1062 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1989 st071868 50.2 µM -2.15298132867213 0.0140430207354622 no 3305 0.0156600729842787 1072 16414057 SGTC_2428 5615643 7.78 µM -2.15705743952534 0.0138962010623205 no 3306 0.0155005946134166 1054 2253075 SGTC_509 pifithrin 175 µM -2.15902719765002 0.013825726882185 no 3307 0.0154240284867396 1083 4817 A p53 inhibitor. SGTC_1417 3966-0327 90.4 µM -2.16130496534731 0.0137446172151709 no 3308 0.0153358948138784 1073 651118 SGTC_2422 chlorphenesin carbamate 384.24 µM -2.20336517629147 0.0123189999552465 no 3309 0.0137845102920366 1065 2724 A muscle relaxant with antifungal properties. SGTC_2377 9073351 62.6 µM -2.22957836951561 0.0114968569410708 no 3310 0.0128877235886547 1074 7337946 YHR072W ERG7 SGTC_3252 9135871 49.47 µM -2.23949838234471 0.0111983950666254 no 3311 0.0125617532288127 1079 17682838 SGTC_484 loperamide 105 µM -2.24229081016347 0.0111156042590683 no 3312 0.0124712916551595 1083 3955 An opioid-receptor agonist. SGTC_557 1315-0110 16.2 µM -2.24953482218149 0.0109033084089577 no 3313 0.0122392449658851 1078 6833801 SGTC_149 3970-0822 46.1 µM -2.25618278536924 0.0107115943806438 no 3314 0.0120295930995404 1060 3114250 YBL034C STU1 SGTC_1575 cyproterone acetate 48 µM -2.25913224753393 0.0106274821338917 no 3315 0.0119375798727009 1075 9880 An androgen receptor antagonist and liver toxin. SGTC_1288 0973-0013 65.5 µM -2.2618392364081 0.0105507915865788 no 3316 0.0118536688481122 1082 4315430 SGTC_2383 9036125 200 µM -2.27200481998327 0.0102670836761703 no 3317 0.0115431096051574 1081 79580 SGTC_21 0849-0113 22.993 µM -2.27361581813172 0.0102227390019377 no 3318 0.0114945477777537 1082 1560156 SGTC_2584 androsterone 48.74 µM -2.27446192607576 0.0101995158342792 no 3319 0.0114691138978373 1032 2754130 A steroid. SGTC_2098 5376439 882.5 nM -2.32599554942413 0.008869097479492 no 3320 0.010009394054889 1078 2844116 SGTC_2244 6635614 200 µM -2.34112404728781 0.00850858553473945 no 3321 0.00961288903035926 1083 836499 SGTC_1044 1222-0021 1.78 µM -2.34295019259459 0.00846595036401409 no 3322 0.00956596847833419 1038 4306703 SGTC_194 1486-1323 56.904 µM -2.36988998151602 0.00785842355241358 no 3323 0.00889668953320466 1081 5178754 SGTC_1507 4075-3230 155 µM -2.37634774649946 0.00771862023281289 no 3324 0.00874248783059748 1065 659771 SGTC_1346 1488-2224 62.4 µM -2.38767282127971 0.00747872474906102 no 3325 0.00847771439464625 1076 3722427 SGTC_860 0443-0016 25.1 µM -2.38798674184399 0.00747216968233215 no 3326 0.00847047645977348 1080 5337942 SGTC_2760 etidronate 98.04 µM -2.38841293402507 0.00746327834044526 no 3327 0.00846065860500381 1067 3305 A chelator and antioxidant. SGTC_1778 st046819 58.9 µM -2.39001844511391 0.00742986735557181 no 3328 0.00842376332656999 1082 671715 SGTC_536 3852-0578 10.6 µM -2.45787974738236 0.00613292097596428 no 3329 0.00698799816965562 1078 2869208 SGTC_1495 4469-0029 237 µM -2.46996689265003 0.00592423890813218 no 3330 0.00675627786425293 1088 793680 SGTC_1624 st003710 6.25 µM -2.47357837283837 0.00586312138624842 no 3331 0.00668837302777828 1079 24207033 SGTC_168 3970-0862 530.542 µM -2.48816915060741 0.00562185632928016 no 3332 0.00642013229651265 1065 3135186 SGTC_2496 diffractaic acid 79.83 µM -2.52028346020792 0.0051216438484286 no 3333 0.00586301809243574 1081 94870 An apoptosis inducer which activates caspases. SGTC_1312 1218-2183 165 µM -2.5647405484397 0.00449462819901744 no 3334 0.00516264903339035 1081 6744073 SGTC_1502 4534-4282 27.7 µM -2.60447038749227 0.00399327190471283 no 3335 0.00460081860632982 1089 3278949 SGTC_508 roscovitine 141 µM -2.64264662453193 0.00355931824548681 no 3336 0.00411304197190622 1092 160355 A CDKinase inhibitor. SGTC_1484 3473-2379 286 µM -2.66411858740332 0.00333430081295074 no 3337 0.00385951728991952 1094 671917 SGTC_2157 5649910 96.377 µM -2.66515928924424 0.00332372700643347 no 3338 0.00384759318448679 1090 2858091 SGTC_303 1348-1668 34.2 µM -2.67519586901198 0.0032232895984993 no 3339 0.00373428009199394 1092 5380509 SGTC_2416 tofa 880 nM -2.67701546679895 0.00320537583264425 no 3340 0.00371406029237708 1080 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1025 k007-0731 70 µM -2.67928973960839 0.00318311180976562 no 3341 0.00368892613556768 1088 6256118 SGTC_50 0929-0078 56.389 µM -2.69385823025131 0.00304376447992721 no 3342 0.00353150999700365 1074 1377751 SGTC_1761 st044296 37 µM -2.79522694939639 0.00221684163954165 no 3343 0.00259316462681055 1089 1826700 SGTC_1416 3966-0321 25.3 µM -2.86436618010145 0.001775877215989 no 3344 0.00208922333026336 1094 582530 YLR208W SEC13 SGTC_69 0096-0274 206.684 µM -2.94559352617129 0.00136062023480551 no 3345 0.00161167841193269 1089 6741392 SGTC_1625 st003711 30.1 µM -3.07298366566013 0.000884776002782374 yes 3346 0.00105965043887601 1094 24207034 YER133W GLC7 SGTC_2619 obliquin 87.91 µM -3.09754866316899 0.000812867010584241 yes 3347 0.000975641783499363 1085 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1765 st044815 90.4 µM -3.12109666321947 0.000749022390617245 yes 3348 0.000900894402072139 1090 645695 SGTC_1092 toremifene 6.32 µM -3.27418983505546 0.000434427690300444 yes 3349 0.000529826987905968 1093 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1833 st055984 71 µM -3.52506484526083 0.000169469126928137 yes 3350 0.000211689569628429 1095 676288 SGTC_1569 carminic acid 40.6 µM -3.73324413734239 7.40962341059513e-05 yes 3351 9.45146042086492e-05 1093 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_514 4466-0038 2.65 nM -3.83630210122338 4.84364760538598e-05 yes 3352 6.2450376950203e-05 1088 5722064 SGTC_1358 1509-0022 2.48 µM -3.94992930156185 2.99510862105272e-05 yes 3353 3.90871401826453e-05 1095 3258434 SGTC_2412 st077135 33.4 µM -4.1310269857278 1.35639957574727e-05 yes 3354 1.80573089432253e-05 1094 13258915 SGTC_3062 9077494 49.47 µM -4.92813007200651 2.83142936664503e-07 yes 3355 4.15101714373426e-07 1030 16459633 SGTC_1366 1683-0113 21.9 µM -5.10295735253109 1.11441698570673e-07 yes 3356 1.67193189374112e-07 1094 708623