SGTCid condition conc unit TIF35|YDR429C.score TIF35|YDR429C.strain.pval TIF35|YDR429C.strain.significant TIF35|YDR429C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3075 9116269 49.47 µM 12.4575109653982 9.83269896073276e-18 yes 1 6.36407103932565e-36 2 17015205 YNL244C SUI1
SGTC_800 3448-7362 155 µM 12.106598711435 7.51282689333983e-17 yes 2 4.87260032155897e-34 3 15991913
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 11.7799024778662 4.7414326694264e-16 yes 3 2.4775184030795e-32 2 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2489 cantharidin 73.42 µM 9.28426328329201 1.22244261254697e-10 yes 4 8.14148519539925e-21 2 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_894 0960-0238 55.9 µM 8.93930904124295 5.47058943146609e-10 yes 5 1.95805621410135e-19 2 6741907 YDL195W SEC31
SGTC_71 0417-1750 47.813 µM 7.8132973113721 5.00118250498054e-08 yes 6 2.78554862015896e-15 2 6811472
SGTC_832 4083-0019 164 µM 7.42168377564889 2.10227587540201e-07 yes 7 5.78203257175099e-14 3 1990758
SGTC_408 cantharidin 100 µM 6.97705234846412 9.87075959569014e-07 yes 8 1.50718707167347e-12 2 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2166 5933061 31.504 µM 6.56624558338291 3.80752902252625e-06 yes 9 2.57998450912281e-11 1 2877375
SGTC_2539 epi(13)torulosol 80 µM 6.51815838828168 4.43737049466098e-06 yes 10 3.5587907698383e-11 2 6708597
SGTC_257 daunorubicin 18.5 µM 6.50525495478695 4.62262617862235e-06 yes 11 3.87808602749364e-11 6 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2358 9037157 4 µM 6.10504803846773 1.58412659780414e-05 yes 12 5.13848835165929e-10 4 2388925
SGTC_1991 st073000 8.92 µM 6.10081673646005 1.60427790889552e-05 yes 13 5.27639228696033e-10 6 4301969 YIL048W NEO1
SGTC_330 1488-0319 80.1 µM 6.0931198099439 1.64156002790404e-05 yes 14 5.53655616151063e-10 2 6846614
SGTC_3193 9111931 49.47 µM 6.06909777640146 1.76328195168348e-05 yes 15 6.43154094956017e-10 1 17087244
SGTC_2357 9067248 200 µM 5.97756730284774 2.31028789542618e-05 yes 16 1.13247182323476e-09 1 9150235
SGTC_2126 5251174 33.877 µM 5.94288559967428 2.55685623221324e-05 yes 17 1.40023942826601e-09 3 790722
SGTC_756 0508-1999 28.3 µM 5.87652211451296 3.09977675351561e-05 yes 18 2.09487729277018e-09 3 6753853
SGTC_2322 7413319 38.22 µM 5.70413395058404 5.06511819568406e-05 yes 19 5.84680475561518e-09 12 1840400
SGTC_91 0417-1751 58.384 µM 5.68084631073451 5.40704330804378e-05 yes 20 6.70149371201756e-09 4 6795624
SGTC_150 3970-0969 77.2 µM 5.65231482056736 5.85566605277778e-05 yes 21 7.91506526927935e-09 6 6615640
SGTC_3131 9127911 49.47 µM 5.57062427967009 7.34216154847171e-05 yes 22 1.26914089506825e-08 3 45595681
SGTC_272 doxorubicin 8.13 µM 5.52224756475392 8.38303950508125e-05 yes 23 1.67345227874712e-08 4 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3286 9117135 37.221 µM 5.47444987563938 9.54660449935691e-05 yes 24 2.1943641949561e-08 2 3438150
SGTC_3103 9120822 49.47 µM 5.40156114604488 0.000116167538953464 yes 25 3.30317060797116e-08 1 17141819
SGTC_2283 7944793 200 µM 5.2905885689862 0.000155920161586577 yes 26 6.09616804992534e-08 4 2970533
SGTC_3145 9085516 49.47 µM 5.09722668925598 0.000257034989382278 yes 27 1.72332753196178e-07 7 25236195
SGTC_273 hydroxyurea 18.1 mM 5.0855283829064 0.000264787372905568 yes 28 1.83301999816555e-07 12 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_134 0269-0018 6.916 µM 5.07929501452139 0.000269006628837071 yes 29 1.89419017953535e-07 12 4378915
SGTC_2007 4011539 71.82 µM 5.01851920235152 0.000313556897029946 yes 30 2.60356446819782e-07 3 45595301
SGTC_422 cantharidin 155 µM 4.94793671348416 0.000373875024762384 yes 31 3.75021426454767e-07 2 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_566 0958-0068 16.5 µM 4.94620883407469 0.000375478536570051 yes 32 3.78363880602886e-07 11 6815365
SGTC_644 1498-1197 63.3 µM 4.8872533433979 0.000434173232099633 yes 33 5.11262397517313e-07 5 6741615
SGTC_3232 9132874 49.47 µM 4.85671275872728 0.000467820936120323 yes 34 5.96752658075382e-07 4 3784940
SGTC_2460 5552655 174.22 µM 4.81472779992223 0.000518029823790483 yes 35 7.37003355464383e-07 5 5401989
SGTC_2009 4012297 12.05 µM 4.79964185154778 0.000537256863066975 yes 36 7.9474810526355e-07 6 45595307
SGTC_3077 9117319 49.47 µM 4.72338806876414 0.000644945083627639 yes 37 1.15973821521698e-06 4 17154678
SGTC_2702 st077768 96.8 µM 4.66550370436896 0.000739631867725848 yes 38 1.53930974590776e-06 2 6484119
SGTC_831 k061-1017 217 µM 4.59533783022256 0.000871529646935555 yes 39 2.16024351166336e-06 7 1240153
SGTC_2172 5754775 163.918 µM 4.57405469952053 0.000915620293940994 yes 40 2.39187430205091e-06 3 2263357
SGTC_81 0411-0046 9.971 µM 4.56448168276375 0.000936112576313209 yes 41 2.50364958037719e-06 32 12925265
SGTC_2050 5263056 171 µM 4.55769449948766 0.000950895745174493 yes 42 2.58590948220162e-06 20 763468 YGL055W OLE1
SGTC_3199 9111318 49.47 µM 4.50194007813078 0.00108069597882244 no 43 3.36679840724353e-06 8 8548020
SGTC_1001 4048-4355 44.4 µM 4.48164940243886 0.00113183197440667 no 44 3.70341763986241e-06 8 21824233
SGTC_188 3229-0966 278.469 µM 4.43459632067772 0.00125905465918391 no 45 4.61224855076745e-06 15 5722370
SGTC_3298 9116858 71.43 µM 4.42759689272876 0.00127905976247259 no 46 4.76443857797235e-06 1 2506942
SGTC_2651 TUB2.036 5 µM 4.39867071140755 0.00136485432647797 no 47 5.44579679157639e-06 43 15992207 YFL037W TUB2
SGTC_2751 anetholtrithion 17.25 µM 4.3981847698968 0.00136633949905708 no 48 5.45800150105183e-06 5 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1425 4048-4433 7.33 µM 4.33766884054918 0.00156326222208917 no 49 7.20009526020104e-06 3 23734946
SGTC_568 1193-0097 7.48 µM 4.29774087773984 0.00170700838261075 no 50 8.62738532913836e-06 23 3646150
SGTC_3153 9100258 49.47 µM 4.28166890243018 0.00176819123917493 no 51 9.27484232452995e-06 3 25236848
SGTC_1846 st056244 14.8 µM 4.24750753739699 0.00190491379387803 no 52 1.08080947454537e-05 3 5393182
SGTC_2119 5528445 120.635 µM 4.23887506146376 0.00194095065456305 no 53 1.12321314351646e-05 2 791935
SGTC_963 1269-2853 151 µM 4.22247684230645 0.00201111640277673 no 54 1.20816115961376e-05 2 3668223
SGTC_309 k408-0051 1.48 µM 4.21084921755112 0.00206225626027937 no 55 1.27206258173875e-05 20 3640463
SGTC_667 1498-1044 59 µM 4.17819884114074 0.0022122278541329 no 56 1.4691336339314e-05 8 6739982
SGTC_1084 voriconazole 435 nM 4.13247283802032 0.00243888602253509 no 57 1.7944059400456e-05 8 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2136 5328288 199.296 µM 4.10658523511334 0.00257632883490145 no 58 2.00775664041607e-05 8 262395
SGTC_785 1270-0111 65.3 µM 4.03092469694173 0.00301906633246947 no 59 2.77789214667753e-05 6 6741994
SGTC_3044 9093193 49.47 µM 4.02835725658006 0.00303522578151664 no 60 2.80839735246353e-05 3 25236277
SGTC_1466 k213-0079 57.5 µM 4.00012745442365 0.0032181110996403 no 61 3.16541889261804e-05 12 3657981
SGTC_1465 k213-0056 144 µM 3.97082555746318 0.00341837148687976 no 62 3.58120048122055e-05 10 24048857 YMR208W ERG12
SGTC_1812 st052057 4.327 µM 3.96340164224708 0.00347085561436256 no 63 3.69446570644784e-05 8 3645418
SGTC_1560 lithocholic acid 53.1 µM 3.95409909599934 0.00353764209080946 no 64 3.84117833172614e-05 3 9903 A bile acid which acts as a detergent.
SGTC_660 4031-1742 102 µM 3.91297074151117 0.00384695404350858 no 65 4.55837921877341e-05 11 6738706
SGTC_1900 st060200 72.8 µM 3.8953385816797 0.00398682553211328 no 66 4.90308253826108e-05 5 688945
SGTC_1005 4092-0690 4.4 µM 3.87009768153337 0.00419498273299787 no 67 5.4395877063284e-05 9 1529343
SGTC_2068 5226020 147 µM 3.83441682144828 0.0045058190593437 no 68 6.29312768731217e-05 7 1810509
SGTC_701 4424-0219 185 µM 3.79597679841747 0.00486355810777972 no 69 7.3531626428222e-05 2 2911779
SGTC_3033 9090887 49.47 µM 3.7277906180893 0.00556081446227586 no 70 9.65828771563674e-05 19 19325384
SGTC_524 r073-0010 27.8 µM 3.72419624639667 0.00559991856919204 no 71 9.79692340347526e-05 16 2772106
SGTC_624 k048-0052 28 µM 3.71936435035379 0.00565287077172753 no 72 9.98623874250926e-05 7 6835531
SGTC_648 0375-0473 33.3 µM 3.70495172082624 0.00581346748748543 no 73 0.000105715500025831 8 1713139
SGTC_3186 9110464 49.47 µM 3.70439684058623 0.00581973051962241 no 74 0.000105947158328499 2 17018021
SGTC_360 0957-0399 1.01 µM 3.70395400068166 0.0058247332270349 no 75 0.000106132382604175 16 6752301 YPR165W RHO1
SGTC_708 3448-5400 146 µM 3.6938323423625 0.00594012129148772 no 76 0.000110449738044035 22 3462195
SGTC_1633 st005664 67.9 µM 3.67175848268453 0.00619882109031704 no 77 0.000120443637445393 7 2063822
SGTC_695 3505-6186 243 µM 3.63783028458381 0.00661592173465013 no 78 0.00013747224670236 10 1819379
SGTC_950 1165-0508 94.1 µM 3.62297549193853 0.00680622114532378 no 79 0.000145616712981491 8 6148369
SGTC_1007 4101-0031 70 µM 3.60980286236319 0.00697899942249499 no 80 0.000153214901666691 6 1146276
SGTC_828 2074-0507 139 µM 3.5768039073084 0.00742893540680499 no 81 0.000173910445636974 9 X828
SGTC_1176 0848-0131 83.3 µM 3.57284826814982 0.00748454979467074 no 82 0.000176559693680594 5 6769040
SGTC_1902 st060212 70.5 µM 3.55631175958231 0.00772103632547363 no 83 0.000188048869518172 6 688944
SGTC_2414 st077232 92.9 µM 3.54294224810845 0.00791701485420157 no 84 0.000197844672761557 10 729801
SGTC_1335 1486-0900 202 µM 3.50510576571601 0.00849554833409698 no 85 0.00022821296085716 7 X1335
SGTC_1232 0279-0259 161 µM 3.48515406382137 0.00881530565031926 no 86 0.000245926878756637 10 1560000
SGTC_1356 1502-0781 85.8 µM 3.47822027888821 0.0089288748490673 no 87 0.000252377471834841 8 567702
SGTC_1129 3453-1384 223 µM 3.4745196520901 0.00899001088360045 no 88 0.000255884437612381 23 1084452
SGTC_1901 st060216 58.6 µM 3.47076395173553 0.00905243134837527 no 89 0.000259489999001204 6 688792
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 3.46802894413803 0.00909812623412818 no 90 0.000262145407605941 11 4174840
SGTC_3182 9108849 49.47 µM 3.46707354875233 0.00911413594510377 no 91 0.000263078950221131 7 17133045
SGTC_2138 5575593 77.673 µM 3.45668984359874 0.00928973448225143 no 92 0.000273426931137645 3 762213
SGTC_1013 4112-3890 241 µM 3.45279383863506 0.00935637944807306 no 93 0.000277406425343342 10 705171
SGTC_1662 st014054 52 µM 3.45230710549125 0.00936473481397409 no 94 0.000277907362414173 2 2838777
SGTC_1545 lovastatin 49.4 µM 3.44629746442328 0.00946843666113126 no 95 0.000284162199152474 11 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1101 ebselen 5.29 µM 3.42781679673493 0.00979365533716378 no 96 0.000304227960672906 9 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2896 9052656 71.43 µM 3.4273593179882 0.00980182820563478 no 97 0.000304741007602885 27 6469436
SGTC_1839 st053978 48 µM 3.42171207449029 0.00990320804629458 no 98 0.000311140868034933 2 3788398
SGTC_1656 st012921 11 µM 3.4103181912551 0.0101105424633089 no 99 0.000324435647215048 6 6732821
SGTC_1250 0485-0349 40.2 µM 3.40975092479412 0.0101209632610796 no 100 0.00032511116412274 18 6842794 YDL195W SEC31
SGTC_2156 5649887 115 µM 3.40235151428089 0.0102577526620297 no 101 0.000334043239846191 23 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_132 0417-1715 25.805 µM 3.38646383026597 0.0105569187336785 no 102 0.000353998043567888 12 6769098
SGTC_1835 st008666 49.2 µM 3.37526711414738 0.0107722936866742 no 103 0.000368720383881221 1 690455
SGTC_2198 6589944 200 µM 3.33471295501426 0.011584711098345 no 104 0.000426937457346921 6 5290268
SGTC_2753 fluvastatin 17.09 µM 3.32711095350232 0.0117427840575445 no 105 0.000438757130972714 14 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_258 haloperidol 50.781 µM 3.30456574331029 0.0122226367313834 no 106 0.000475618314683233 26 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_78 0336-0123 156.75 µM 3.29770519587038 0.0123719890783997 no 107 0.000487392102650898 13 6765896
SGTC_3155 9099265 49.47 µM 3.27600241793709 0.0128549093558134 no 108 0.000526438297306802 15 25236499
SGTC_184 1494-0393 24.714 µM 3.27411887969467 0.0128975797038944 no 109 0.000529960051122552 46 3090647
SGTC_2379 9035213 200 µM 3.26930936673148 0.0130070922489807 no 110 0.000539051781681387 11 646551
SGTC_1905 st060207 84.5 µM 3.26609191001786 0.0130808016653118 no 111 0.000545214256148729 7 1948547
SGTC_1673 st016611 27.3 µM 3.2657724484403 0.0130881399450845 no 112 0.000545829671431079 11 5226799
SGTC_2053 5265679 138 µM 3.26494193642911 0.0131072341002884 no 113 0.000547432588823125 11 764595
SGTC_3119 9125183 49.47 µM 3.26364071602646 0.0131371986382598 no 114 0.000549952745545728 6 22695334
SGTC_1003 4049-0218 100 µM 3.26016631520108 0.0132174974579739 no 115 0.000556734503554647 20 295161
SGTC_2147 5545932 89.7195 µM 3.23885196329431 0.013719444659421 no 116 0.000600059229348654 19 797404
SGTC_66 0109-0187 42.4 µM 3.2371821166488 0.0137594547326506 no 117 0.000603581734634363 12 759417
SGTC_1979 st071809 45.3 µM 3.23293846766098 0.0138615871476677 no 118 0.000612619751805532 11 4976333
SGTC_3234 9132280 49.47 µM 3.21194906150949 0.0143764092590337 no 119 0.000659188744603584 10 17612295
SGTC_168 3970-0862 530.542 µM 3.18104740477923 0.0151642824939167 no 120 0.000733718077016871 65 3135186
SGTC_830 4076-0286 57.8 µM 3.15753438701165 0.0157883656402692 no 121 0.000795547348511485 13 6866659
SGTC_98 0074-0023 107.663 µM 3.14481165226392 0.0161351461602297 no 122 0.000830968948492953 8 3563821
SGTC_2880 9042983 58.44 µM 3.14286854061748 0.0161886794456699 no 123 0.000836504789493861 26 6464714
SGTC_1884 5633444 25 µM 3.1238436162791 0.016720908662582 no 124 0.000892526510673533 33 5724239
SGTC_1399 3562-5772 25 µM 3.12203449519052 0.0167722902071972 no 125 0.000898029463949587 19 23847490
SGTC_3058 9093861 49.47 µM 3.11426462359377 0.0169945037229016 no 126 0.000922020109578759 12 17217477
SGTC_376 3970-0862 59.1 µM 3.07508808241108 0.0181536462453438 no 127 0.00105220197084127 23 3135186
SGTC_100 0086-0128 49.5915 µM 3.0580584260387 0.0186781480165975 no 128 0.00111388068284229 22 93297
SGTC_94 0334-0113 514.748 µM 3.05637453638079 0.0187307045295667 no 129 0.00112015608652753 8 6795178
SGTC_2606 farnesol 9.78 µM 3.0507381356096 0.0189075409661762 no 130 0.00114139787331788 23 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1245 0418-0076 17.2 µM 3.04017033889894 0.0192429240623989 no 131 0.00118222190113523 18 6790114
SGTC_1094 duloxetine 25.4 µM 3.02746500049975 0.0196528261969953 no 132 0.00123307135339422 13 60834 A selective serotonin reuptake inhibitor.
SGTC_176 1486-1328 72.834 µM 3.02023414199477 0.0198894027762799 no 133 0.00126289671653085 25 22310231
SGTC_2038 4100038 30.985 µM 3.01565746043638 0.0200403863557597 no 134 0.00128211379865434 26 3596803
SGTC_663 1486-0733 13.9 µM 3.01562289320124 0.0200415304092322 no 135 0.00128225995547809 15 722445 YPR165W RHO1
SGTC_2662 daunorubicin 22.37 µM 3.01424521104861 0.0200871719506324 no 136 0.00128809747638068 28 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1162 k048-0130 20.1 µM 3.00535984264245 0.0203836600682453 no 137 0.00132633409102875 19 6797406
SGTC_227 fluconazole 33.516 µM 2.98960220832447 0.0209185859179072 no 138 0.00139670486764279 64 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_867 0518-0118 155 µM 2.96980678618899 0.0216073787209596 no 139 0.00148993552768977 22 6848158
SGTC_600 1495-0418 41.6 µM 2.96855288611487 0.0216516469144955 no 140 0.00149602804630188 16 5377768
SGTC_2495 cafestol 54.53 µM 2.96485091434027 0.0217827901540005 no 141 0.00151414823488225 24 16667697 An anti-infammatory.
SGTC_55 0767-0285 6.563 µM 2.95882804367556 0.0219975853666627 no 142 0.00154405683128185 20 3116166
SGTC_1238 0333-0287 48.8 µM 2.95561043389188 0.0221130668056857 no 143 0.00156025480336628 9 7226
SGTC_777 1315-0167 517 µM 2.95242497108988 0.0222278980913773 no 144 0.00157644340358475 9 4221767
SGTC_2146 5545642 200 µM 2.95135390403896 0.0222666213526493 no 145 0.00158192089313155 12 825326
SGTC_2680 butyl paraben 22.24 µM 2.94929812086508 0.0223411054231432 no 146 0.00159248289883685 4 7184 An antifungal and steroid mimetic.
SGTC_2097 5376186 200 µM 2.945029569756 0.0224964327795659 no 147 0.00161461899675835 10 742755
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.94496206273478 0.0224988965737648 no 148 0.00161497131969157 20 5379071
SGTC_595 3909-8003 73.7 µM 2.92815857822832 0.0231192886186394 no 149 0.00170488044569234 17 699517
SGTC_394 menadione 8.33 µM 2.9258516908788 0.0232055740323956 no 150 0.00171757328554116 17 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2765 myclobutanil 7.74 µM 2.92582679411568 0.0232065067324886 no 151 0.00171771073921044 26 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3122 9126309 49.47 µM 2.91815711612181 0.0234953398369966 no 152 0.00176053442519769 14 17591206
SGTC_886 0866-0150 153 µM 2.91133518732353 0.0237547830775431 no 153 0.00179943857653732 15 271463
SGTC_1473 k844-0725 134 µM 2.91091439297095 0.0237708647745253 no 154 0.00180186369892121 21 54682906
SGTC_2589 lobaric acid 100 µM 2.90707879458196 0.0239178740595981 no 155 0.00182410645052804 11 73157 A novel microtubule depolymerizer.
SGTC_3211 9128781 49.47 µM 2.88961202427183 0.0245970309125181 no 156 0.00192858773889816 21 17194361
SGTC_575 k072-0246 11.9 µM 2.88610190302708 0.024735449204511 no 157 0.00195022922600897 17 6796779
SGTC_2717 st081029 62.2815 µM 2.87701875558294 0.0250966705665137 no 158 0.00200725866760333 10 5292846
SGTC_881 0833-0569 170 µM 2.87116247257935 0.0253319013665976 no 159 0.00204482633589007 19 5418700
SGTC_1304 1165-0502 251 µM 2.86232346989647 0.0256904357289133 no 160 0.0021027372961648 17 767425
SGTC_262 fenpropimorph 62.5 µM 2.85582016466601 0.0259569318105852 no 161 0.00214629097200428 35 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2191 5911152 200 µM 2.85042653025087 0.0261797060045486 no 162 0.00218303179312704 14 2875902
SGTC_912 3474-0017 2.18 µM 2.83265086596267 0.0269252433055134 no 163 0.00230818881713315 20 3360550
SGTC_3210 9128157 49.47 µM 2.82983539656904 0.0270449387515354 no 164 0.00232859788333649 36 17590849
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.81879224740647 0.027518716583032 no 165 0.00241023533834377 19 1273210
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.80763557304618 0.0280043712866734 no 166 0.00249533340085455 17 2374 Ca(2+)-ATPase inhibitor.
SGTC_1616 st002734 56.1 µM 2.80578373754213 0.0280856691330464 no 167 0.00250971839364064 17 4026101
SGTC_15 0266-0086 27.098 µM 2.80350332852229 0.0281860517885701 no 168 0.00252753552412644 27 1712902 YIL048W NEO1
SGTC_1742 st038235 28.8875 µM 2.80301276415883 0.0282076852196537 no 169 0.00253138328038671 25 564103 YBR002C RER2
SGTC_2887 9044784 58.44 µM 2.80069077606998 0.0283102703606929 no 170 0.00254966781075796 43 6465546
SGTC_1705 st027868 56.3335 µM 2.76268985175821 0.0300337374645056 no 171 0.00286636056501161 12 292948
SGTC_1815 st051655 58.2 µM 2.75838448587575 0.0302343744330892 no 172 0.00290439155119311 36 5984156
SGTC_464 bw-b 70c 158 µM 2.74057983762045 0.0310759314376225 no 173 0.00306654398927945 22 5353454
SGTC_2725 haloperidol 53.21 µM 2.73946545614448 0.0311292421073423 no 174 0.00307695906714231 39 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1089 terbinafine 2.25 µM 2.73106134568474 0.0315337260771432 no 175 0.00315653596404438 15 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1308 1187-1617 41.4 µM 2.72928935154275 0.0316195631298682 no 176 0.00317354924751162 36 2882570
SGTC_1344 1488-0097 29.1 µM 2.72157637349151 0.031995439433146 no 177 0.00324856850943964 13 747966
SGTC_1429 4049-0205 9.46 µM 2.71707825468515 0.0322163443392425 no 178 0.00329305167798052 10 22774478
SGTC_1965 Pectolinarigenin 58.4 µM 2.71325635845626 0.0324050274587914 no 179 0.00333127709139693 12 5320438 An anti-inflammatory.
SGTC_356 1634-0012 32.5 µM 2.71035948853285 0.0325486496450627 no 180 0.00336051595231564 24 735457
SGTC_970 1315-0089 19.5 µM 2.70975464769465 0.0325787028490062 no 181 0.00336664980011869 25 6811083 YLR033W RSC58
SGTC_2776 terbinafine 19.92 µM 2.68803137190231 0.0336733493417188 no 182 0.0035937321810116 26 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_658 3253-0951 102 µM 2.68319494889071 0.033921134101412 no 183 0.00364612340925059 29 1184878
SGTC_3190 9110366 49.47 µM 2.68141880037761 0.0340125073145989 no 184 0.00366553518226693 16 17123768
SGTC_984 1492-0255 2.91 µM 2.67385147298475 0.0344040762832344 no 185 0.00374928269376705 14 1585198
SGTC_574 1315-0397 40 µM 2.6676538709528 0.0347275216784758 no 186 0.00381914519846327 25 6794277
SGTC_2309 7664088 163.95 µM 2.65413369725745 0.0354417923637428 no 187 0.00397561579462347 30 704922
SGTC_1020 4335-0961 93.3 µM 2.64284404243678 0.03604741422019 no 188 0.00411064469647871 29 669075
SGTC_1467 k284-1082 293 µM 2.64104572070676 0.0361446613822405 no 189 0.00413252824248852 17 3334705
SGTC_557 1315-0110 16.2 µM 2.64062435570925 0.0361674784142749 no 190 0.00413767082864904 22 6833801
SGTC_2362 9071156 126 µM 2.63438565540251 0.0365066878663294 no 191 0.00421448444761934 21 653133
SGTC_1090 efavirenz 20.7 µM 2.62969389549803 0.0367634986615367 no 192 0.00427308905108876 24 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_513 4245-1575 41.7 µM 2.61945136270573 0.0373292744375032 no 193 0.0044035665349309 64 719745
SGTC_1224 0823-0416 294 µM 2.60879304184578 0.03792554893066 no 194 0.00454310883787903 17 3598164
SGTC_386 1509-0011 3.07 µM 2.60558025699397 0.0381068033630303 no 195 0.00458593915701412 20 3107280
SGTC_2302 7771753 200 µM 2.60371288516596 0.0382124784319326 no 196 0.00461099877508619 28 2203047
SGTC_2767 sibutramine 71.45 µM 2.60160201220479 0.0383322209176656 no 197 0.00463947320554639 13 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1283 0922-0125 16.4 µM 2.59520065868329 0.0386972190870497 no 198 0.0047267854990359 13 3360884
SGTC_163 TUB2.036 7.546 µM 2.5938837523107 0.0387726577113173 no 199 0.00474492837293007 80 15992207 YJR013W GPI14
SGTC_2436 5633522 8.09 µM 2.57643079771192 0.03978380557031 no 200 0.00499130928369785 43 5724242
SGTC_130 0136-0219 337.655 µM 2.57558343344071 0.0398334387652108 no 201 0.00500355634457878 28 234244
SGTC_1650 st011916 45.8 µM 2.57451261061821 0.0398962327207749 no 202 0.00501907135861945 15 242528
SGTC_2653 dihydrofissinolide 100 µM 2.56529796953524 0.0404399184640892 no 203 0.00515436176340929 17 6857746
SGTC_1904 st060225 78 µM 2.56088456829616 0.0407024420958054 no 204 0.00522030197771715 23 66595
SGTC_2014 4013930 200 µM 2.55718475345838 0.0409235834297896 no 205 0.00527615778428316 28 64556
SGTC_736 0958-0254 92.6 µM 2.54005148916677 0.0419603934459937 no 206 0.00554180751779911 26 6812352
SGTC_1029 k015-0030 64.7 µM 2.53792222480571 0.0420907173970364 no 207 0.00557563816773236 25 2208316
SGTC_2521 angolensin 13.4 µM 2.52242632125996 0.0430490572343373 no 208 0.00582741813634058 20 821428 A flavenoid.
SGTC_231 b-estradiol 524 µM 2.51913997609722 0.0432545490394904 no 209 0.00588209394563738 18 450 A steroid.
SGTC_2953 9074162 66.49 µM 2.51589578939464 0.0434581809548955 no 210 0.00593651415766246 24 16451992
SGTC_3305 9127027 53.8275 µM 2.5131248426501 0.0436327205666192 no 211 0.00598334895365589 25 41905295
SGTC_249 wiskostatin 11.211 µM 2.51223068756092 0.0436891632173996 no 212 0.00599853179765489 18 2775510 A n-wasp and actin depolymerizer.
SGTC_1520 flindersine 88 µM 2.51200755032641 0.0437032577149924 no 213 0.00600232601147555 30 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_157 1348-1695 65.819 µM 2.50771303836446 0.0439752367134941 no 214 0.00607576532428992 61 5380510
SGTC_2023 5144124 124 µM 2.50421244683801 0.044197943728918 no 215 0.00613621594043984 20 2830192
SGTC_2796 7949634 45.45 µM 2.50304294603982 0.0442725494580492 no 216 0.00615653010114135 32 2971588
SGTC_2278 7948257 134.34 µM 2.50123763593635 0.0443879144856693 no 217 0.00618800520317881 18 1247028
SGTC_361 000s-0510 1.45 µM 2.49946457912638 0.0445014540952075 no 218 0.0062190566272623 27 660
SGTC_1986 st071812 45 µM 2.49724546631038 0.044643886933608 no 219 0.00625811418490399 11 11838594
SGTC_3094 9117742 49.47 µM 2.49563325027403 0.044747596455764 no 220 0.0062866261044724 35 17149698
SGTC_782 0083-0095 30.5 µM 2.49200057410471 0.0449819878443004 no 221 0.00635129160473868 27 3591729 An indicator and reagent.
SGTC_2148 5546263 113.568 µM 2.48350462750297 0.0455340314842591 no 222 0.00650483220510174 27 792097
SGTC_1141 3253-0389 52.6 µM 2.48144400779313 0.0456687425691113 no 223 0.00654256331905444 26 5402031
SGTC_3133 9127736 49.47 µM 2.47195367685903 0.0462933048771308 no 224 0.00671884636494767 16 27243420
SGTC_2975 9084847 53.72 µM 2.47032538034074 0.0464011498006841 no 225 0.00674951027554595 39 27211724
SGTC_1914 st062367 72.6 µM 2.46792253468129 0.0465606627777112 no 226 0.00679498629488356 29 978205
SGTC_802 4112-3352 742 µM 2.46600131147572 0.0466885195848514 no 227 0.00683154169906285 18 704594
SGTC_385 1494-0393 12.4 µM 2.46470615094495 0.0467748709667637 no 228 0.00685628283399156 26 3090647
SGTC_2823 7987624 58.44 µM 2.46269952602256 0.046908910315417 no 229 0.006894771196605 45 2239440
SGTC_1339 1486-1321 22.7 µM 2.45538705222272 0.0473999806297906 no 230 0.00703664850673951 32 3469382
SGTC_3174 9107204 49.47 µM 2.44811940039542 0.0478921138187476 no 231 0.00718020290957492 18 3938802
SGTC_691 1548-0686 185 µM 2.44254139038738 0.0482725996085897 no 232 0.0072921285709921 52 46495133
SGTC_118 0083-0097 135.343 µM 2.43796207491054 0.0485867669122514 no 233 0.00738516176399453 63 5207356
SGTC_1227 3909-8010 46.6 µM 2.43528225652122 0.0487713747238017 no 234 0.0074400886777599 21 15982272
SGTC_1437 4092-1038 11.6 µM 2.42336052316766 0.049599445536716 no 235 0.00768882854280477 33 3977136
SGTC_3011 9081274 71.4286 µM 2.41984763408315 0.0498455755767341 no 236 0.0077635057476802 30 6625322
SGTC_770 0389-1121 67.2 µM 2.41925596326538 0.0498871266037823 no 237 0.00777614612846361 30 6753108
SGTC_1146 3579-1023 7 µM 2.41796718762957 0.0499777285516624 no 238 0.00780374207102054 26 X1146
SGTC_1252 0493-0875 34.8 µM 2.408019887928 0.0506814539598987 no 239 0.00801965362448934 31 3960963
SGTC_1489 4065-0444 182 µM 2.40158311609399 0.051141015880734 no 240 0.00816215006454276 20 2877968
SGTC_286 k060-0067 22.9 µM 2.39085687470073 0.0519141909365308 no 241 0.00840455207542595 37 5985051
SGTC_2333 9017922 200 µM 2.38829362945555 0.0521003244787342 no 242 0.00846340592365877 16 3163164
SGTC_505 gw-5074 63.9 µM 2.38460037920996 0.0523694466225787 no 243 0.00854884141959027 31 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1557 sumaresinolic acid 42.3 µM 2.38369250290903 0.052435771058133 no 244 0.00856995872019355 21 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3281 9140613 49.47 µM 2.37867881450657 0.0528032452528977 no 245 0.00868740381178459 21 16013766
SGTC_2985 9022375 71.43 µM 2.3734039481198 0.0531920647030542 no 246 0.00881248826791967 36 4939335
SGTC_104 0074-0074 590.992 µM 2.37233809577431 0.0532709054817633 no 247 0.00883795399023709 53 3943124
SGTC_1710 st031758 61.5 µM 2.36337559061046 0.0539375288982328 no 248 0.00905465291167411 30 5394341
SGTC_3306 9127676 59.7925 µM 2.35761629592184 0.0543693742938354 no 249 0.00919634659001052 20 41905287
SGTC_1847 st056231 15 µM 2.35654399326735 0.0544500792721559 no 250 0.00922294128899903 38 5393180
SGTC_3191 9110352 49.47 µM 2.33641389511608 0.0559827909490659 no 251 0.00973484022772094 20 17122424
SGTC_1974 st069448 26.9 µM 2.33252894008736 0.0562824733024147 no 252 0.00983644114388078 25 6323587 YNR016C ACC1
SGTC_2625 euphol 100 µM 2.33056334786008 0.0564345785915288 no 253 0.0098881980221645 39 6708538 A triterpene alcohol.
SGTC_2687 chenodiol 100 µM 2.32788004607644 0.0566427458808881 no 254 0.00995923703918538 33 5702181 A cholesterol synthesis inhibitor.
SGTC_2867 9039098 71.43 µM 2.31698716904914 0.0574940207119338 no 255 0.010252215363806 36 6463460
SGTC_1039 k821-0043 94 µM 2.31609804597605 0.0575639472818441 no 256 0.0102764579888748 33 15992768
SGTC_2268 7933382 153.85 µM 2.31542271800235 0.0576171042646159 no 257 0.0102949047155013 44 935025 YOR257W CDC31
SGTC_2028 5153890 36.43 µM 2.31195366284645 0.0578907721865462 no 258 0.0103901184950844 46 2830968 YPR165W RHO1
SGTC_1674 st016616 23.6 µM 2.31152081955004 0.057924990045432 no 259 0.0104020522713943 34 625830
SGTC_1469 k284-2957 126 µM 2.3112402048186 0.0579471821676297 no 260 0.010409795387553 41 23884841
SGTC_2217 6934799 96.0675 µM 2.30687293086477 0.0582934254544902 no 261 0.0105309524907267 19 675606
SGTC_1055 3448-0672 86 µM 2.30084170002981 0.058774258783203 no 262 0.0107002902199144 50 748378
SGTC_3109 9122853 49.47 µM 2.30076765067944 0.058780181571993 no 263 0.0107023839394338 24 1234709
SGTC_3088 9117578 49.47 µM 2.29700373724879 0.0590818532137746 no 264 0.0108092782698523 38 678341
SGTC_799 1310-0557 151 µM 2.29009873415697 0.0596384342931329 no 265 0.0110077968718861 35 5354492
SGTC_1813 st051246 8.6015 µM 2.28832237658254 0.0597822808432228 no 266 0.0110593771700557 21 5291959
SGTC_583 1488-1091 88.9 µM 2.28802952919122 0.0598060212261471 no 267 0.0110679007677033 48 4303273
SGTC_1338 1486-1223 76 µM 2.27887202745199 0.0605521292094821 no 268 0.0113373368383813 26 3444526
SGTC_2234 tolnaftate 200 µM 2.27853974138714 0.0605793385284609 no 269 0.0113472197530111 9 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3177 9107506 49.47 µM 2.27658756928296 0.0607393857891822 no 270 0.0114054329429817 20 8897194
SGTC_2254 7938975 95.19 µM 2.26536422873198 0.061665946570439 no 271 0.011745168786847 46 2969277
SGTC_718 1130-0073 349 µM 2.26197099670309 0.0619482422682016 no 272 0.0118495976455881 34 6740020
SGTC_1963 st076565 50.3 µM 2.25722124727093 0.0623450843559988 no 273 0.0119971267026634 43 4914280
SGTC_1949 st076024 69.1 µM 2.25681500134878 0.0623791180714475 no 274 0.012009818485763 39 2921930
SGTC_2621 lithochol-11-enic acid 100 µM 2.24369456308407 0.0634861065965776 no 275 0.0124260300869613 36 6708711
SGTC_1679 SEC14.276 6.7 µM 2.23959237902873 0.0638353327488739 no 276 0.0125586989630708 76 1005053 YMR079W SEC14
SGTC_1075 aripiprazole 15.2 µM 2.23762758577167 0.0640031273993324 no 277 0.0126226755438745 35 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1282 0886-0010 32.4 µM 2.23751706054946 0.0640125765056689 no 278 0.012626282774248 57 2836211 YNL267W PIK1
SGTC_1745 st081495 74 µM 2.22935366379398 0.0647134912031709 no 279 0.0128951913387202 76 13842402 YBL026W LSM2
SGTC_449 xestospongin c 11.1929 µM 2.22558557482518 0.0650390256926556 no 280 0.0130209766537933 27 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_795 0685-0265 78 µM 2.22449008758212 0.0651339056105451 no 281 0.0130577443450041 63 302754
SGTC_1871 st057448 67.3 µM 2.22090123750288 0.0654454875884221 no 282 0.0131788257024543 48 691747
SGTC_1959 st077091 55.8 µM 2.21741221449489 0.0657495096599554 no 283 0.0132974678982589 64 821356 YKL052C ASK1
SGTC_1108 betulinic acid 729.144 nM 2.20458378650594 0.0668767567057672 no 284 0.0137416572657333 36 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2231 micatex 6.853 µM 2.20042689885496 0.0672452163670474 no 285 0.0138883105601479 37 20737 An antifungal of unknown mechanism.
SGTC_3260 9137109 49.47 µM 2.19691421386976 0.0675577967797645 no 286 0.0140132867586756 26 17478346
SGTC_2721 ifenprodil 61.44 µM 2.19223626735623 0.0679758110697765 no 287 0.0141812254896768 42 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2185 6113692 200 µM 2.18965562101714 0.06820726697517 no 288 0.0142746109462323 43 874150
SGTC_2307 7538926 6.34 µM 2.18093705743093 0.0689937278092574 no 289 0.0145940361545043 68 96582
SGTC_2367 9070478 135.38 µM 2.17742842888045 0.0693121900512689 no 290 0.0147243082348953 50 572802
SGTC_2994 9053520 71.4286 µM 2.17288806323227 0.0697259776811272 no 291 0.014894371548582 38 4647384
SGTC_834 0312-0008 75.7 µM 2.16260204977217 0.0706704279561004 no 292 0.0152859002381286 43 6385573 YIL048W NEO1
SGTC_2536 dehydroabietamide 32.04 µM 2.15844808924934 0.0710546150319203 no 293 0.0154465051389718 35 3983547
SGTC_1109 tnp00067 928.257 nM 2.15259076669157 0.071599063640179 no 294 0.0156754274181528 29 676295
SGTC_882 0843-0131 351 µM 2.14416917793531 0.0723874673564679 no 295 0.0160096668761554 64 5425421
SGTC_219 mitoxanthrone 164.414 µM 2.14057553069122 0.0727259116282971 no 296 0.0161541419014601 47 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2601 securinine 100 µM 2.14019278028253 0.0727620297652637 no 297 0.0161695951991677 68 442872 A GABA receptor antagonist.
SGTC_3301 9125354 19.7965 µM 2.13986692985232 0.072792789373668 no 298 0.0161827611770009 28 41905162
SGTC_590 k048-0076 22.4 µM 2.13979181390195 0.0727998815763016 no 299 0.0161857975372813 53 6832814
SGTC_2658 polymyxin b sulfate 77.05 µM 2.13800669176145 0.072968582702181 no 300 0.0162581000622823 55 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1385 3091-4834 14.1 µM 2.13623335473994 0.0731364661962738 no 301 0.0163301990000049 37 4072814
SGTC_2639 lactacystin 53 µM 2.13469179814142 0.0732826468191374 no 302 0.0163930966986047 44 3870 A proteasome inhibitor.
SGTC_625 k213-0058 121 µM 2.13227857492212 0.0735119333320288 no 303 0.016491976143164 76 3655420
SGTC_1181 1222-0449 220 µM 2.12646741430139 0.0740663172627427 no 304 0.0167321798536673 37 658318
SGTC_1851 st056236 18.9 µM 2.12527023289919 0.074180923963686 no 305 0.0167820353022919 43 5393171
SGTC_3166 9102297 49.47 µM 2.12216146905516 0.0744791597976312 no 306 0.0169120904821431 38 25237072
SGTC_358 0075-0058 9.45 µM 2.11972577286223 0.0747134644680501 no 307 0.0170145891001304 51 1069125
SGTC_3003 9075612 71.4286 µM 2.11269055749181 0.0753933840171691 no 308 0.0173136310081091 42 6501993
SGTC_3352 9151559 45.5865 µM 2.11262577804899 0.0753996664762788 no 309 0.0173164052777307 41 17159339
SGTC_2654 protoveratrine a 100 µM 2.10465268351618 0.0761759662779191 no 310 0.0176607760356313 43 5702278 A heart drug and vasodilator.
SGTC_2911 7942208 15.64 µM 2.10077934344118 0.0765552824505732 no 311 0.0178301702742578 31 1243384
SGTC_678 1218-2179 85.9 µM 2.09932973618456 0.0766976113515221 no 312 0.017893921930981 25 6820081 YOR116C RPO31
SGTC_3230 9131665 49.47 µM 2.08979432897267 0.0776388598238226 no 313 0.018318139504663 15 15943720
SGTC_126 0417-1624 672.48 µM 2.0894955190837 0.0776684966959979 no 314 0.0183315704456401 70 41912 YDL195W SEC31
SGTC_1669 st015249 58.4 µM 2.08710509665659 0.0779058953043603 no 315 0.0184393177332997 32 722793
SGTC_2780 5215298 71.43 µM 2.08588050309156 0.0780277257438565 no 316 0.0184947243963756 71 2834131
SGTC_2903 5923464 63.88 µM 2.07927939986518 0.0786869367715358 no 317 0.0187958387087893 35 2876576
SGTC_151 3013-0144 2.285 µM 2.07884004071235 0.0787309621821983 no 318 0.0188160276305775 68 906558 YHR107C CDC12
SGTC_3113 9123498 49.47 µM 2.06900102193783 0.0797217642119216 no 319 0.0192729954009631 46 8897275
SGTC_1770 st043884 66.3 µM 2.06691122392399 0.0799334188658647 no 320 0.0193712599671401 71 670149
SGTC_1772 st048439 82.2 µM 2.05979968641222 0.0806568588654733 no 321 0.0197088472894466 46 2927068 YDL195W SEC31
SGTC_2387 9077560 195.08 µM 2.05842759918541 0.0807970053757228 no 322 0.0197745523275903 50 5303272
SGTC_2194 5927483 104.545 µM 2.05264972715598 0.0813891814785426 no 323 0.0200532805205138 36 760979
SGTC_2833 9001315 45.46 µM 2.05182710838557 0.0814737575006058 no 324 0.0200932338963265 55 2989378
SGTC_1704 st028805 70.8 µM 2.04867308737073 0.0817986466311034 no 325 0.0202470462678897 48 2876101
SGTC_2681 menadione 3.18 µM 2.04338293851979 0.0823457648909523 no 326 0.0205072725400036 50 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_276 colchicine 750 µM 2.03900458458137 0.0828006638272854 no 327 0.0207247849985369 49 2833 A microtubule depolymerizer.
SGTC_2549 cedrol 20.94 µM 2.03720816837521 0.0829878526220449 no 328 0.0208145928184177 67 6708665 A sedative which affects the nervous system.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.03249793368367 0.0834801762138727 no 329 0.0210516363767214 47 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_321 4534-3890 65.3 µM 2.03024271185516 0.0837166723634435 no 330 0.0211659371177736 51 699746
SGTC_3194 9111903 49.47 µM 2.02246437035685 0.0845362181989456 no 331 0.0215642004318642 42 17087251
SGTC_1183 1254-0324 198 µM 2.01565777089095 0.0852583037151108 no 332 0.021917887145879 32 5799357
SGTC_3220 9131269 49.47 µM 2.01428677022517 0.0854043053119295 no 333 0.0219897170762033 43 17722206
SGTC_1840 st055363 71 µM 2.00889496543056 0.0859803100656295 no 334 0.0222741369844785 38 676033
SGTC_3335 9143315 29.6265 µM 2.00213355715485 0.0867067313031372 no 335 0.0226351846436388 41 4899691
SGTC_2993 9054257 71.4286 µM 2.00103972140355 0.0868246788173094 no 336 0.0226940547197071 94 6470217 YGL055W OLE1
SGTC_1192 1488-0095 21.4 µM 1.99735937622362 0.0872224080323776 no 337 0.0228930787486271 41 915875
SGTC_3139 9095020 49.47 µM 1.99659926245954 0.0873047215812046 no 338 0.0229343665235497 34 25236292
SGTC_1115 galangin 695.678 nM 1.98755939933484 0.0882881084412521 no 339 0.0234302201899901 43 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2406 ethylparaben 405.7 µM 1.98618938137803 0.0884378611646529 no 340 0.0235061497373321 50 8434 A possible steroid mimic.
SGTC_2440 5628896 157.78 µM 1.98581506021996 0.0884788100345734 no 341 0.0235269314461037 41 5522048
SGTC_2923 7992654 58.14 µM 1.98130966700752 0.0889727863481596 no 342 0.0237782784759718 54 2985126
SGTC_2791 5663188 71.43 µM 1.98083086130325 0.0890254035794252 no 343 0.0238051223244098 69 54690634
SGTC_1485 3909-9022 254 µM 1.97502678983728 0.0896650715623217 no 344 0.0241325539518483 34 714516
SGTC_1646 st011709 75.6 µM 1.97248279992109 0.0899465199604411 no 345 0.0242772589555963 60 5757843
SGTC_2564 betulinic acid 100 µM 1.97070674296205 0.0901433986927261 no 346 0.0243787144140752 62 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1521 st012942 49.4 µM 1.96997447382551 0.0902246650296483 no 347 0.0244206480635161 52 24207259
SGTC_3240 9133527 49.47 µM 1.96822117549257 0.0904194650580417 no 348 0.024521297421007 38 17617455
SGTC_1776 st049249 45.9 µM 1.96771352134558 0.090475926179133 no 349 0.0245505045889933 75 1822314
SGTC_2401 5128683 200 µM 1.96652101889736 0.0906086588529714 no 350 0.0246192284001533 56 708373
SGTC_2370 9071495 200 µM 1.9645014074212 0.0908337833225586 no 351 0.0247359866109661 58 21791103
SGTC_933 2914-0560 114 µM 1.95967755651023 0.0913731731668856 no 352 0.0250167450057566 47 463887
SGTC_712 r015-0009 80.6 µM 1.95516588221105 0.0918798017662413 no 353 0.0252817470604923 39 6813872 YLR060W FRS1
SGTC_1877 wortmannin 25 µM 1.9511434404167 0.0923332447863615 no 354 0.0255199924540096 57 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1939 st074455 53.6 µM 1.94718211416525 0.0927814148465735 no 355 0.0257564526031154 53 1644229
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.93848160277519 0.0937714020268971 no 356 0.0262822465954079 43 4213774
SGTC_705 1124-0212 310 µM 1.93687046947286 0.093955577282656 no 357 0.0263805895276645 67 9554485
SGTC_2276 7947513 42.08 µM 1.93245847334801 0.0944612969038414 no 358 0.0266514714148104 44 2105100
SGTC_3159 9100096 49.47 µM 1.93108879710203 0.094618701876607 no 359 0.0267360360931359 52 25236875
SGTC_1709 st033179 39.1045 µM 1.93053585905781 0.0946823009856947 no 360 0.0267702382715338 45 573381
SGTC_733 4069-0007 56.1 µM 1.92937770284517 0.0948156145818966 no 361 0.0268419948530298 69 5717425 YNL287W SEC21
SGTC_311 1315-0136 58 µM 1.92643843392387 0.0951545702074578 no 362 0.0270248261490333 49 6759207
SGTC_352 k048-0007 5.11 µM 1.92336392456941 0.0955100757335761 no 363 0.0272171808109101 86 6811911
SGTC_1178 0988-0033 191 µM 1.91611279618067 0.0963523933293145 no 364 0.0276753699376296 54 5392207
SGTC_1257 0669-0121 16 µM 1.91453947215096 0.0965358749965202 no 365 0.0277756303092586 55 4307855
SGTC_3338 9144300 39.5675 µM 1.91071279492021 0.0969832147778322 no 366 0.0280207498142632 36 4901274
SGTC_2749 bexarotene 57.39 µM 1.90709105256315 0.0974079975180642 no 367 0.0282543988489529 55 82146 An retinoic acid receptor inhibitor.
SGTC_2531 methyl deoxycholate 70.07 µM 1.90687041869486 0.0974339190029874 no 368 0.0282686848246018 60 16667744 Haematoxylin.
SGTC_2523 spermine 47.74 µM 1.90598729140586 0.0975377251326919 no 369 0.028325927254686 35 1103 A DNA binding polyamine.
SGTC_2467 5474540 200 µM 1.90548555236004 0.0975967375611258 no 370 0.028358491860751 67 5413519
SGTC_2678 equilin 100 µM 1.90514420618852 0.0976369002192594 no 371 0.0283806642150965 38 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_404 fumagillin 50 µM 1.89880464696349 0.0983850142451408 no 372 0.0287950829967697 55 12015870 A methionine aminopeptidase binder.
SGTC_26 0302-0163 425.158 µM 1.8931967072414 0.0990502833891291 no 373 0.0291658575717337 72 3100915
SGTC_2580 diallyl disulphide 81.36 µM 1.89191485735078 0.0992028100183481 no 374 0.0292511629488004 71 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2852 9023854 51.95 µM 1.89154777882271 0.0992465201130439 no 375 0.0292756296629935 66 19798528
SGTC_2655 perillic acid 100 µM 1.88652396080648 0.0998461500446045 no 376 0.0296121913304569 45 5702197 An apoptosis inducer.
SGTC_2294 7971431 200 µM 1.88571081103128 0.099943453799272 no 377 0.0296669676216807 58 5741572
SGTC_2810 7959871 45.46 µM 1.8854391975735 0.0999759712424406 no 378 0.0296852830699358 70 2974535
SGTC_300 r073-0011 5.04 µM 1.8841811561658 0.100126684172829 no 379 0.029770237779508 54 2735780
SGTC_274 sirtinol 40.1 µM 1.88140006496488 0.100460446458082 no 380 0.0299587590220949 73 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3138 9097216 49.47 µM 1.88013789395821 0.100612188726342 no 381 0.0300446435930564 61 25237486
SGTC_909 3448-9333 149 µM 1.88008541651378 0.100618501352147 no 382 0.0300482188426725 51 3344074
SGTC_1642 st009582 77.7 µM 1.87745116755831 0.100935752234922 no 383 0.0302281421059062 74 6739311
SGTC_2950 9072895 21.46 µM 1.87606357165086 0.101103157722008 no 384 0.0303232755444864 59 17332245
SGTC_717 1532-0246 73.2 µM 1.86972787231704 0.10187009511203 no 385 0.0307608084638013 62 9561992
SGTC_1449 4112-4002 201 µM 1.86958198249824 0.101887804835844 no 386 0.0307709446150649 53 2059539
SGTC_2433 5607874 27.82 µM 1.8680052555378 0.102079348430968 no 387 0.0308806691901595 51 2252428
SGTC_659 k018-0002 107 µM 1.86771771922426 0.102114307080945 no 388 0.0309007137415868 63 6797879 YHR007C ERG11
SGTC_43 0570-0105 72.5 µM 1.85997898012199 0.103058456805096 no 389 0.0314442499642616 65 1114046 YDL195W SEC31
SGTC_2057 5236571 38.335 µM 1.85943023341017 0.103125645525895 no 390 0.0314830898560633 67 54684039 YBR257W POP4
SGTC_1571 st070080 73.4 µM 1.85646362695759 0.103489428673513 no 391 0.0316937514315512 46 4315245
SGTC_1328 1441-0025 69.2 µM 1.85255400967875 0.103970270787173 no 392 0.0319731547453603 37 4562601
SGTC_2571 chrysanthemic acid 100 µM 1.84941631323545 0.10435734499869 no 393 0.0321988608251533 56 2743 An insecticide.
SGTC_2030 5175110 200 µM 1.84362208157105 0.105074878935906 no 394 0.032619117823688 56 2831986
SGTC_1377 2944-0135 198 µM 1.84148571283778 0.105340337045139 no 395 0.032775206190893 55 1894137
SGTC_2964 9083345 53.42 µM 1.83601394280926 0.106022452952705 no 396 0.0331777972897929 77 17741579
SGTC_814 3342-0569 96 µM 1.83590922161629 0.106035538645565 no 397 0.0331855418099425 66 4346283
SGTC_2897 9048598 12.99 µM 1.83540899632711 0.106098061621154 no 398 0.0332225558715767 29 6467404
SGTC_1635 st007035 42.4 µM 1.8352984463824 0.106111882811065 no 399 0.0332307405771111 76 3716403
SGTC_1741 st038134 10.228 µM 1.83095162747312 0.106656362873497 no 400 0.0335538817178114 62 1272587
SGTC_982 1491-0518 27.5 µM 1.82092179371876 0.107920381852364 no 401 0.0343093729077757 52 3091256
SGTC_2235 salicylic acid 500 µM 1.8199602012221 0.108042131780958 no 402 0.0343825329648819 51 338 A COX inhibitor and kinase inhibitor.
SGTC_1756 st041558 35.5 µM 1.81853138529759 0.108223220773992 no 403 0.0344914771176007 64 3955792
SGTC_1291 0993-0025 5.79 µM 1.81565234378187 0.108588775622139 no 404 0.0347118593701878 57 4353356
SGTC_2366 9070441 60.58 µM 1.81421320673332 0.108771836911198 no 405 0.0348224538433579 59 6837235
SGTC_3322 9139058 2.11 µM 1.80460621719534 0.109999553294774 no 406 0.0355681622500201 76 4908926 YPR165W RHO1
SGTC_2255 7941087 197.44 µM 1.80355427014703 0.110134587467632 no 407 0.0356506052269538 63 935561
SGTC_2670 beta-carotene 100 µM 1.80063673504833 0.110509721735045 no 408 0.0358800775804505 27 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1769 st044406 64.4 µM 1.79963064943083 0.110639295552517 no 409 0.0359594890936469 94 670903
SGTC_2079 5212404 121 µM 1.79931259311038 0.110680280685404 no 410 0.0359846235808139 56 758462
SGTC_3356 9151811 4.48 µM 1.7957703594502 0.111137472836652 no 411 0.0362655233011144 71 1859254 YPR165W RHO1
SGTC_1319 1306-0155 43.7 µM 1.79308837301103 0.111484532295561 no 412 0.0364793972386567 76 3122360
SGTC_1025 k007-0731 70 µM 1.79277179148093 0.111525550297566 no 413 0.03650471087265 57 6256118
SGTC_3083 9117465 49.47 µM 1.78851980237523 0.112077507645168 no 414 0.0368460918608914 63 16420915
SGTC_2706 st078239 82.5 µM 1.78092052534753 0.113068840247414 no 415 0.037462717494471 73 15434492
SGTC_1285 0929-0069 65.5 µM 1.78053220300613 0.113119664764543 no 416 0.0374944519831343 53 1206237
SGTC_1724 st037281 8.293 µM 1.77895149895305 0.113326719162681 no 417 0.0376238569537819 75 574124 YDL195W SEC31
SGTC_3245 9134821 49.47 µM 1.77608211029891 0.113703267181878 no 418 0.0378596922079869 78 17014901
SGTC_1314 1222-0010 41.1 µM 1.77507033212372 0.113836254621615 no 419 0.037943137458247 62 3526027
SGTC_223 busulfan 5 mM 1.77226452614318 0.114205627682122 no 420 0.0381753284352758 57 2478 A DNA alkylator.
SGTC_840 0245-0196 390 µM 1.76861415978805 0.114687460253825 no 421 0.0384791430608519 62 3827528
SGTC_31 0508-1974 57.237 µM 1.76788411875113 0.114783995833379 no 422 0.0385401391501524 49 6810525
SGTC_2416 tofa 880 nM 1.76765871020439 0.11481381397829 no 423 0.0385589883054928 54 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1850 st056238 17 µM 1.75503459173503 0.116492599204481 no 424 0.0396266955239952 67 5393177
SGTC_2102 5377816 72.7585 µM 1.75478114604874 0.116526480363751 no 425 0.0396483748741783 78 1379702
SGTC_637 1181-0519 7.26 µM 1.74918412743862 0.117276483748538 no 426 0.0401295984285607 81 6252091 YGR060W ERG25
SGTC_1774 st048371 48.465 µM 1.74767296854388 0.117479564728325 no 427 0.04026033607082 93 4242727
SGTC_823 0417-1665 178 µM 1.74708342199174 0.117558859938684 no 428 0.0403114343031177 71 3429856
SGTC_178 4092-0806 87.505 µM 1.74681223280186 0.11759534815687 no 429 0.0403349569772386 89 2169044
SGTC_664 1222-0054 14.9 µM 1.74669166758024 0.117611572653854 no 430 0.0403454182606171 80 6813991
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.74207721336731 0.118233732369646 no 431 0.0407474671181583 62 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_753 1322-0200 289 µM 1.7412156942145 0.118350146988337 no 432 0.0408228886371703 48 5403907
SGTC_1349 flufenamic acid 69 µM 1.73680010934609 0.118948084294252 no 433 0.0412112298809046 68 3371 A non-steroidal anti-inflammatory.
SGTC_1362 1611-0397 101 µM 1.73268548792137 0.119507183863128 no 434 0.0415757926364719 74 27816
SGTC_357 1325-0123 420 µM 1.72667095969275 0.120327776542441 no 435 0.0421133869882818 64 1098503
SGTC_2591 skatole 100 µM 1.72557658910595 0.120477512882408 no 436 0.042211807043228 80 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1424 4048-1941 275 µM 1.72375699032416 0.120726768350547 no 437 0.0423758609834615 67 X1424
SGTC_1321 1326-2144 215 µM 1.72115127353857 0.12108434098632 no 438 0.0426116885715011 71 3513030
SGTC_123 0083-0120 66.675 µM 1.71922212206311 0.121349550663899 no 439 0.0427869670768689 89 16001701
SGTC_2249 haloperidol 116.36 µM 1.71761165672865 0.121571261632304 no 440 0.0429337363552281 121 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1210 3013-0140 750 nM 1.7104917857589 0.122554857547 no 441 0.0435874855545379 67 905973
SGTC_2722 naftopidil 47.16 µM 1.70758200272864 0.122958441134398 no 442 0.0438569650729039 67 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1631 benzylvanillin 81.9 µM 1.70537967093489 0.123264520919975 no 443 0.0440618186394301 76 75506
SGTC_516 3992-2719 87.3 µM 1.70497134465488 0.123321328672531 no 444 0.0440998844410807 54 5350887 YDR037W KRS1
SGTC_281 1672-3440 14.9 µM 1.70482306056813 0.123341963002792 no 445 0.0441137146350627 61 6833000
SGTC_1201 1889-3372 45.9 µM 1.70437914639795 0.123403749914275 no 446 0.0441551386280943 76 5392199
SGTC_1211 1056-0033 32.3 µM 1.70412620779489 0.123438965278283 no 447 0.0441787556958774 64 6741922
SGTC_2879 9041815 71.43 µM 1.70295764814969 0.123601749318782 no 448 0.044287997217072 37 4942971
SGTC_2560 caryophyllene 100 µM 1.70234658085518 0.123686932752503 no 449 0.0443452088056991 81 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2463 5473429 200 µM 1.700629886502 0.123926461699199 no 450 0.0445062542242098 58 5399405
SGTC_2865 9030313 51.95 µM 1.69509048705152 0.124701582748593 no 451 0.0450291282875712 53 42562754
SGTC_432 NS 1619 61.3 µM 1.693034431319 0.124990144406018 no 452 0.04522445678078 72 4552 A K+/calcium channel activator.
SGTC_1484 3473-2379 286 µM 1.69255334643665 0.125057730604834 no 453 0.0452702588667273 50 671917
SGTC_791 1348-1292 225 µM 1.69039959464526 0.125360617769357 no 454 0.0454757662827325 62 5437054
SGTC_1366 1683-0113 21.9 µM 1.69021484136349 0.125386623884528 no 455 0.0454934300155965 67 708623
SGTC_3354 9151612 71.43 µM 1.68750650153653 0.12576828563917 no 456 0.0457530004178102 64 27261949
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.6850493985678 0.126115243303515 no 457 0.0459895206016183 63 16486 A toxic proline analog.
SGTC_859 0439-0102 54.6 µM 1.6824323096969 0.126485525157969 no 458 0.0462425202805186 105 610143
SGTC_96 0929-0093 37.281 µM 1.68224137783361 0.126512568986233 no 459 0.0462610217372146 85 6991579
SGTC_1134 3477-0009 42.5 µM 1.68098308114435 0.12669089644925 no 460 0.0463831004463639 98 3973534
SGTC_930 2810-3379 265 µM 1.67886331045783 0.126991708826486 no 461 0.0465893432289608 80 1015764
SGTC_517 1365-0151 113 µM 1.6728896440218 0.127842092838726 no 462 0.0471745114326943 76 768657
SGTC_1950 st077106 7.18 µM 1.67128294838058 0.128071488497578 no 463 0.047332901428748 73 13831864
SGTC_3289 9119912 71.43 µM 1.66867080852675 0.128445046265112 no 464 0.0475913187028345 74 17014829
SGTC_642 0335-0876 158 µM 1.66756710149361 0.128603112654493 no 465 0.0477008467830095 82 6812350
SGTC_2895 9054447 58.44 µM 1.66680247806675 0.128712696617404 no 466 0.0477768436722698 69 2697450
SGTC_47 0149-0135 24.25 µM 1.66546544793625 0.128904472169624 no 467 0.047909965741427 82 5239155
SGTC_2657 nystatin 74.44 µM 1.66419250677635 0.129087239261179 no 468 0.0480369825210018 67 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3323 9138564 53.9225 µM 1.65658821125449 0.130182795535511 no 469 0.0488013786853694 85 43912313 YNL103W MET4
SGTC_1708 st033234 31.827 µM 1.64952757238767 0.131205771954057 no 470 0.0495197996409185 80 674664
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.64810312525426 0.131412823321536 no 471 0.0496657555561586 88 442882
SGTC_1516 st013856 110 µM 1.64715545136932 0.131550697926613 no 472 0.0497630489249775 71 5281404 A mutagen and neurotoxin.
SGTC_398 bronopol 33.3 µM 1.64092496957044 0.132459640425104 no 473 0.0504064955368509 96 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1231 0242-0792 125 µM 1.63663240883895 0.133088378861252 no 474 0.0508536498281603 70 3707635
SGTC_1388 3346-4487 254 µM 1.63429846055272 0.13343109681556 no 475 0.0510980983907334 79 3345614
SGTC_2096 5468907 200 µM 1.63218812828891 0.133741501071467 no 476 0.0513199304557907 80 759785
SGTC_728 3030-5151 22.5 µM 1.6315569079503 0.133834442290626 no 477 0.0513864311593771 53 3125388
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.63032123351943 0.134016512143363 no 478 0.0515168110786141 96 688662
SGTC_397 arbidol 50 µM 1.62667513815362 0.134554735970342 no 479 0.0519030558620345 83 131410 A RNA synthesis inhibitor.
SGTC_1911 st060208 74.3 µM 1.62313145329463 0.135079262349249 no 480 0.0522806535646974 86 688783
SGTC_302 1094-0063 18.9 µM 1.6221572255585 0.135223710236285 no 481 0.0523848438920062 111 5440289
SGTC_1068 loratadine 26.9 µM 1.61944631705198 0.135626211429604 no 482 0.0526756340422986 78 3957 A H1 histamine antagonist.
SGTC_893 0958-0369 48.9 µM 1.61886418662462 0.13571274997792 no 483 0.0527382439884406 86 6819948
SGTC_400 oxethazaine 37.5 µM 1.61773010103885 0.135881449864003 no 484 0.0528603879894203 85 4621 A local anesthetic.
SGTC_3235 9132602 49.47 µM 1.61470765335333 0.136331752449428 no 485 0.053187009690879 98 4912240
SGTC_561 1550-0330 72.9 µM 1.61132625713722 0.136836742170016 no 486 0.0535543153521215 80 6812934
SGTC_185 k048-0037 25.491 µM 1.61008422137349 0.137022552871523 no 487 0.0536897356070762 60 6827589
SGTC_1260 0700-1617 7.75 µM 1.60426722535009 0.137895079522238 no 488 0.0543275810847973 91 2853078
SGTC_2827 7993847 71.43 µM 1.60289892728445 0.138100868314111 no 489 0.0544784852860589 74 2985692
SGTC_2834 9001755 58.44 µM 1.59897658234643 0.138691939914089 no 490 0.0549129030121659 86 2989575
SGTC_937 3122-0005 46.7 µM 1.59848164007498 0.138766646721345 no 491 0.0549679141257284 82 759535
SGTC_3142 9086498 49.47 µM 1.59112618274612 0.139880113216006 no 492 0.0557905905839741 127 25236367
SGTC_511 blebbistatin 171 µM 1.59066406464829 0.139950270660922 no 493 0.0558425991436685 74 3476986 A myosin inhibitor.
SGTC_3341 9147222 25.867 µM 1.58879049799474 0.14023495516008 no 494 0.0560538496092781 83 1939759
SGTC_2341 7987486 176.74 µM 1.58826204734104 0.140315323189409 no 495 0.0561135478800985 78 1258686
SGTC_456 gingerol 170 µM 1.58674578009775 0.140546094313666 no 496 0.0562851166379892 79 442793 A herb.
SGTC_2065 5221596 34.26 µM 1.58584694105246 0.140683016366667 no 497 0.0563870171970928 91 788581
SGTC_2162 5663267 200 µM 1.58320494160983 0.141086001702069 no 498 0.0566873802594833 96 6456493
SGTC_443 clozapine 122 µM 1.5767901034329 0.142067714963674 no 499 0.0574219147834732 63 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2250 alverine citrate 130 µM 1.57407122441879 0.142485198375453 no 500 0.0577354921089888 119 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1653 st012112 65 µM 1.57153113963881 0.142875976965292 no 501 0.0580296635768311 63 720429
SGTC_2970 9090938 41.86 µM 1.5713158808658 0.142909126649022 no 502 0.0580546470977703 98 17217104
SGTC_1505 k297-0037 20.6 µM 1.57077703847207 0.142992130748657 no 503 0.0581172236797631 85 4089396
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.56349015591551 0.144117812213454 no 504 0.0589686746626717 95 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3179 9107801 49.47 µM 1.56275808736364 0.144231231951726 no 505 0.0590547529456044 64 4818259
SGTC_1197 1601-0112 267 µM 1.56127694629109 0.14446088984966 no 506 0.0592292102960365 92 7350313
SGTC_2848 9016370 25.97 µM 1.55903296687904 0.144809298650384 no 507 0.0594942888243473 74 7894410
SGTC_1389 3405-0187 19 µM 1.55825833696914 0.144929701917297 no 508 0.0595860105019299 79 799890
SGTC_1728 st035614 33.7865 µM 1.55778972739398 0.145002572150106 no 509 0.0596415509748531 106 15945546
SGTC_237 nikkomycin 200 µM 1.55778200342945 0.145003773456965 no 510 0.0596424667731277 91 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_974 1326-0144 138 µM 1.55292810744389 0.145760024184773 no 511 0.060220155473631 92 5411856
SGTC_3053 9095903 49.47 µM 1.55076041079964 0.146098612318836 no 512 0.060479555628459 98 17174018
SGTC_1717 st033143 58.0435 µM 1.54920620420263 0.146341699986381 no 513 0.0606660792612776 83 674616
SGTC_2742 clothiapine 36.27 µM 1.54848554202347 0.146454508180476 no 514 0.0607527200070498 56 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_808 0711-0032 135 µM 1.54426373973623 0.147116536611235 no 515 0.0612622265187686 98 4252555
SGTC_317 4495-0002 170 µM 1.54067042806842 0.147681588541838 no 516 0.0616985087628627 84 15991618
SGTC_1008 4106-0037 6 µM 1.53956497621362 0.147855713954071 no 517 0.0618332141016354 108 2905394
SGTC_1764 st044502 93.5 µM 1.53655129031437 0.14833111304614 no 518 0.0622016142594554 87 8407
SGTC_2728 chlorpromazine 9.18 µM 1.53084160888911 0.149234597374007 no 519 0.0629042716450134 78 2726 A thorazine and dopamine antagonist.
SGTC_1766 st045414 44.774 µM 1.52946829875781 0.149452453277968 no 520 0.0630741960632704 106 253960
SGTC_1903 st060211 78.3 µM 1.52858015837271 0.149593456956159 no 521 0.0631842789708124 90 688960
SGTC_955 1216-0110 33 µM 1.52192610564317 0.150652696579887 no 522 0.0640137985695118 87 3619719
SGTC_1504 k297-0033 30 µM 1.51839437824244 0.151216926332407 no 523 0.0644575040217248 53 4388117
SGTC_1729 st035615 45.989 µM 1.51755792938189 0.151350763260348 no 524 0.0645629397004423 98 17385451
SGTC_1932 st074806 40.9 µM 1.5157512279401 0.151640115300069 no 525 0.0647911343844763 112 17251235
SGTC_2165 5727197 32.143 µM 1.51522357763765 0.151724690394643 no 526 0.0648578970620976 88 1361712
SGTC_2816 7982706 58.44 µM 1.51487157763939 0.151781128587094 no 527 0.0649024647033337 107 2981853
SGTC_214 4373-3496 70 µM 1.51466224173971 0.151814699235019 no 528 0.064928980541237 139 3779166
SGTC_1750 st081859 2.357 µM 1.51189741674867 0.152258549826826 no 529 0.065279980664433 125 5291695
SGTC_1934 st074720 32.6 µM 1.50967340552036 0.152616205588773 no 530 0.0655633902516371 105 17250992
SGTC_1594 piperine 70.1 µM 1.50746817059614 0.152971391725266 no 531 0.065845348255624 82 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2081 5214970 32.255 µM 1.50302099888877 0.153689341101709 no 532 0.0664168145371976 81 2063512
SGTC_2697 mebhydrolin 72.4 µM 1.50187063176361 0.153875418429337 no 533 0.0665652612758764 95 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_696 1560-0013 611 µM 1.49305856153887 0.155305756426355 no 534 0.0677109291642821 108 1650269
SGTC_3121 9125696 49.47 µM 1.49086704556932 0.155662832185421 no 535 0.0679982024608215 71 1235365
SGTC_377 3970-0964 33.1 µM 1.48854034505545 0.156042526431294 no 536 0.0683042252722677 100 16481235
SGTC_559 1550-0661 158 µM 1.48839068711695 0.156066969984746 no 537 0.068323945579951 86 5830875
SGTC_1076 itraconazole 331 nM 1.48751708464483 0.156209705376143 no 538 0.0684391471707223 107 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1294 1000-1494 117 µM 1.48651938486127 0.156372821834971 no 539 0.0685708966605009 91 712797 YDL207W GLE1
SGTC_1735 st034310 56.75 µM 1.48587257026288 0.156478631105251 no 540 0.0686564150935255 111 871153
SGTC_144 4161-2749 112.381 µM 1.48398292145605 0.15678801960063 no 541 0.0689067257356877 131 797501 YMR168C CEP3
SGTC_2423 st077119 87.2 µM 1.48193116329646 0.157124405480192 no 542 0.0691793060291923 98 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2345 9052315 157.45 µM 1.48191116944061 0.157127685807504 no 543 0.0691819663356175 103 6469265
SGTC_1111 tnp00062 510.699 nM 1.47845716371183 0.157695049310859 no 544 0.0696427272997826 91 676306
SGTC_599 1935-0052 86.5 µM 1.47728834671653 0.15788734645536 no 545 0.0697991801980332 79 9557311
SGTC_2770 toltrazuril 17.5 µM 1.47668178579984 0.157987200271798 no 546 0.0698804784247724 80 68591 Kills coccidiodes.
SGTC_710 3448-4187 58 µM 1.4766588951829 0.157990969403203 no 547 0.0698835479131807 106 3946412
SGTC_1980 st071811 45.7 µM 1.47495616829012 0.158271503141441 no 548 0.0701121639664661 111 4974850
SGTC_454 lyso-paf C-16 6.67 µM 1.47167242565866 0.158813440458823 no 549 0.0705546786207738 89 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1056 3448-1962 115 µM 1.4715607180628 0.158831897654416 no 550 0.0705697699220925 108 715507
SGTC_2677 mitomycin C 100 µM 1.47152368751949 0.158838016438337 no 551 0.0705747731651144 99 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_339 3091-4833 71.4 µM 1.47150764026695 0.158840668072337 no 552 0.0705769414141501 128 3240077
SGTC_1186 1319-0216 26 µM 1.45966284590645 0.160805805785558 no 553 0.0721913789186173 109 4565136
SGTC_905 2-aminofluorene 215 µM 1.45920779015516 0.160881618147243 no 554 0.072253962670795 89 1539 An established DNA mutagen. YPR165W RHO1
SGTC_769 0302-0231 76 µM 1.45854009040442 0.160992899261747 no 555 0.0723458665737914 130 571869 YER009W NTF2
SGTC_2931 9014674 55.67 µM 1.45851106028094 0.160997738660319 no 556 0.0723498643852312 94 2996810
SGTC_692 k241-0027 77.8 µM 1.45761460032027 0.161147227647225 no 557 0.0724734014865098 100 3600480
SGTC_473 2-arachidonoylglycerol 10 µM 1.44911706258049 0.162568728989542 no 558 0.0736524468971922 104 5282280 An endocannabinoid.
SGTC_1281 0884-0031 11.8 µM 1.44756317827372 0.162829548516429 no 559 0.0738696276794127 104 1548255
SGTC_2022 5136654 200 µM 1.44505507802111 0.163251106970579 no 560 0.0742212077843948 123 1713771
SGTC_11 0438-0307 1.3 µM 1.44140183615488 0.16386640699639 no 561 0.0747355959231341 121 4011476
SGTC_470 aa-861 153 µM 1.44129761172634 0.163883983126906 no 562 0.0747503108659379 111 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3265 9137266 49.47 µM 1.44102039206814 0.163930738667236 no 563 0.0747894609283921 71 17224265
SGTC_3314 9135860 59.4275 µM 1.44079263516775 0.163969158353297 no 564 0.0748216373685424 92 25252478
SGTC_2857 9024691 58.44 µM 1.43988453215224 0.164122401836681 no 565 0.0749500349700585 112 16478292
SGTC_772 k072-0172 35.3 µM 1.43941917855832 0.164200966806802 no 566 0.0750158968800832 89 5861980
SGTC_578 3460-0051 92 µM 1.43910648324042 0.164253772400938 no 567 0.0750601777172625 121 2876744
SGTC_2552 juarezic acid 87.02 µM 1.43800382291948 0.164440069115356 no 568 0.0752164847246449 87 1549512
SGTC_819 1013-0258 27.7 µM 1.43647204439757 0.164699093427703 no 569 0.0754340328090697 102 5753198
SGTC_2614 arthonioic acid 13.39 µM 1.42870221261269 0.166017043428612 no 570 0.0765449208010103 85 6710684
SGTC_2120 5538279 151.968 µM 1.42381232738685 0.166849969664589 no 571 0.0772504031191128 90 2058197
SGTC_166 k072-0058 166.424 µM 1.42362851351792 0.166881332370031 no 572 0.0772770186580073 120 5846229
SGTC_2317 5986382 200 µM 1.41935225691062 0.167612029331608 no 573 0.0778981720554378 110 877883
SGTC_527 4476-4215 268 µM 1.41877344905414 0.167711090094635 no 574 0.0779825378767633 81 4418754
SGTC_763 3453-1109 128 µM 1.41391033444964 0.168544882381751 no 575 0.078694115605409 93 1560353
SGTC_3350 9150499 3.57 µM 1.41127331716685 0.168998117526275 no 576 0.0790820195185205 118 4910996 YPR165W RHO1
SGTC_3313 9133968 57.047 µM 1.41017383269201 0.169187321532246 no 577 0.0792441801998833 101 1494643
SGTC_1954 st077032 68.9 µM 1.40674250249276 0.169778673715176 no 578 0.0797518788294506 106 698907
SGTC_1147 3809-1045 12.3 µM 1.40491776073969 0.170093687183639 no 579 0.0800228672722875 120 325925
SGTC_789 1309-1135 70.6 µM 1.40199206393976 0.170599544767092 no 580 0.0804588082755806 90 3092424
SGTC_544 k015-0020 52.4 µM 1.40134630106561 0.170711327809501 no 581 0.0805552708982513 120 3008304
SGTC_74 000s-0487 160.283 µM 1.39333798096598 0.172101480659352 no 582 0.0817588052203549 89 677548
SGTC_1555 citronellol 128 µM 1.39322002577519 0.172122010180582 no 583 0.0817766329143378 95 8842 A terpine precursor.
SGTC_3078 9116413 49.47 µM 1.39130486371441 0.172455553410878 no 584 0.0820664997927867 110 17177322
SGTC_868 0527-0199 213 µM 1.39089964124321 0.172526179467045 no 585 0.0821279308154501 115 2849450
SGTC_2354 9060492 162 µM 1.38763250263742 0.173096281411709 no 586 0.082624489467657 119 6471895
SGTC_2935 9038016 29.96 µM 1.3870797237 0.173192857566084 no 587 0.0827087270490322 117 6463195
SGTC_2389 9091542 195.52 µM 1.38568169187744 0.173437261178923 no 588 0.0829220605116862 135 3626624 YOL127W RPL25
SGTC_2851 9015922 71.43 µM 1.38298607069283 0.173909128468848 no 589 0.0833345684907633 127 2996893
SGTC_2286 7945697 125 µM 1.37758982451511 0.17485618926109 no 590 0.0841649821775806 114 1245733
SGTC_1626 st003712 1.76 µM 1.37369883557231 0.175541099020995 no 591 0.0847675992753307 134 24207035
SGTC_54 0159-0055 9 µM 1.37163695802627 0.175904728457216 no 592 0.0850882413031663 109 3319099
SGTC_174 3553-0389 74.3 µM 1.37121861908607 0.175978564215909 no 593 0.0851534078563464 101 738071
SGTC_3231 9132313 49.47 µM 1.36380523734807 0.177290261212741 no 594 0.0863144357551646 111 4905967
SGTC_1336 1486-0901 104 µM 1.3615450232946 0.177691400307905 no 595 0.0866707577120756 108 5006114
SGTC_3036 9090181 49.47 µM 1.36104986631556 0.17777935637091 no 596 0.0867489656343724 112 25236586
SGTC_1234 0326-0494 15.5 µM 1.36019490519781 0.177931290048406 no 597 0.0868841272000957 134 1547813
SGTC_3279 9140807 49.47 µM 1.35939865764074 0.17807286345983 no 598 0.0870101481276276 112 45595718
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.35935813574038 0.178080070182559 no 599 0.0870165651180847 113 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2719 novobiocin 32.65 µM 1.35823533128475 0.178279831390351 no 600 0.0871945114577962 107 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_389 tpck 16.7 µM 1.35671710475433 0.178550167688871 no 601 0.0874355577220289 93 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1204 4049-0315 18.3 µM 1.35640409941061 0.178605933686733 no 602 0.0874853148336047 109 588402
SGTC_2431 5490079 200 µM 1.35140377651384 0.179498293439298 no 603 0.0882830623618484 144 5722345
SGTC_533 1222-0222 6.71 µM 1.3509885699925 0.179572517176286 no 604 0.0883495470695366 128 3982874
SGTC_1687 st020778 55.3625 µM 1.34959365902585 0.179822017459206 no 605 0.0885731796312709 116 4259299
SGTC_1217 1183-1422 255 µM 1.34915705116964 0.179900155901078 no 606 0.0886432633133871 114 2849664
SGTC_3225 9130819 49.47 µM 1.34420898479825 0.180787186738249 no 607 0.0894404085317942 121 4547121
SGTC_108 0509-0257 621.132 µM 1.3395962090637 0.181616575521567 no 608 0.090188328481591 140 536624
SGTC_3001 9076041 71.4286 µM 1.33863794960362 0.181789171243522 no 609 0.090344282747579 94 16004211
SGTC_2399 5884133 200 µM 1.33676574777954 0.182126676516415 no 610 0.0906495565013301 122 722445
SGTC_293 4049-0273 38.5 µM 1.33343733587344 0.182727661913734 no 611 0.0911941634441537 120 1380311
SGTC_2875 9039966 71.43 µM 1.33289026852118 0.182826559944681 no 612 0.0912839082847982 107 6463691
SGTC_1135 dihydrocapsaicin 536.708 nM 1.33034847312652 0.183286500090888 no 613 0.0917017415889836 127 107982 A Capsaicinoid.
SGTC_1836 st055642 81 µM 1.32803597376456 0.183705575165802 no 614 0.0920831115185032 138 8571
SGTC_3010 9080089 71.4286 µM 1.32686965785952 0.183917163211608 no 615 0.0922759014737868 102 17027233
SGTC_1428 4049-0204 61.7 µM 1.32659021898115 0.183967880346366 no 616 0.0923221365572002 130 X1428
SGTC_2977 9011197 71.43 µM 1.32192951604883 0.184815064412196 no 617 0.0930958113416493 126 2704722
SGTC_313 3474-0040 5.03 µM 1.32144141934372 0.184903926656654 no 618 0.0931771115670399 143 1043375 YIL048W NEO1
SGTC_680 0417-1641 114 µM 1.31922106230199 0.185308496971446 no 619 0.0935476094083409 122 2835990
SGTC_1091 telmisartan 47.6 µM 1.31886036081101 0.18537427209558 no 620 0.0936079001161755 131 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2450 5739737 12.93 µM 1.31708576335109 0.185698086908368 no 621 0.0939049392697604 108 2262825
SGTC_543 3844-1095 191 µM 1.31527522742527 0.186028820907119 no 622 0.0942087102887717 143 4230703
SGTC_1276 0871-0068 94.2 µM 1.3132507454522 0.186399068994573 no 623 0.0945492348048675 140 3414906
SGTC_1459 k035-0031 35.7 µM 1.31315765150149 0.186416105484797 no 624 0.094564915307021 107 3877128 YMR208W ERG12
SGTC_1562 morin hydrate 59.1 µM 1.3128315063791 0.186475798691971 no 625 0.0946198654636288 121 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1849 st056239 19.2 µM 1.30370672347954 0.188150672161637 no 626 0.0961667980663312 115 5393181
SGTC_1067 clotrimazole 1.36 µM 1.29818554936106 0.189168589103872 no 627 0.0971117912747956 136 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_426 0988-0037 14.6 µM 1.29389556576975 0.189961852788865 no 628 0.0978507481854769 149 5383008
SGTC_3045 9092950 49.47 µM 1.29372822542627 0.189992837183 no 629 0.0978796561336453 96 44120432
SGTC_2656 pseudo-anisatin 100 µM 1.29059380510967 0.190573773907996 no 630 0.098422282626738 116 6708809 A neurotoxin.
SGTC_1506 4226-2149 212 µM 1.29015173259986 0.190655795744277 no 631 0.0984989905073393 130 991114
SGTC_3283 9109332 35.8195 µM 1.28874737929693 0.190916502230747 no 632 0.0987429625490998 98 17027281
SGTC_3147 9097027 49.47 µM 1.28171454886373 0.192225375556422 no 633 0.0999713996864856 147 25236841
SGTC_2237 6667747 47.222 µM 1.28097610503318 0.192363124338063 no 634 0.100101029603466 114 729940 YDL015C TSC13
SGTC_2730 imipramine 71.33 µM 1.2797157104037 0.192598376844346 no 635 0.100322568645579 117 3696 A tricyclic antidepressant.
SGTC_2274 7947094 46.08 µM 1.27757181247509 0.192998938860933 no 636 0.100700222318784 133 2971028
SGTC_205 1486-1330 71.903 µM 1.27498116678445 0.193483648645245 no 637 0.101157954029812 121 4118834
SGTC_1414 3917-0015 5.4 µM 1.27142087987773 0.194150988542236 no 638 0.101789479190837 120 6618702
SGTC_2638 epoxomicin 18 µM 1.27069286843817 0.194287619403103 no 639 0.101918966833545 110 9915668 A protesome inhibitor.
SGTC_1832 st054113 55 µM 1.2699212762932 0.194432493246469 no 640 0.102056336770139 111 1251267
SGTC_1150 3909-7983 10.9 µM 1.26974927942025 0.194464796273957 no 641 0.102086976482196 150 23965914
SGTC_2929 9013348 24.6 µM 1.26861016856628 0.194678817086724 no 642 0.102290067897288 113 2995952
SGTC_869 0564-0080 44.1 µM 1.26845940970291 0.194707153013825 no 643 0.102316968611605 106 6843321
SGTC_2003 4023581 200 µM 1.26697974637616 0.194985396721649 no 644 0.102581265993793 109 16641307
SGTC_1771 st048882 4.1505 µM 1.26687888297726 0.195004372405262 no 645 0.102599300260213 135 4580403
SGTC_913 3487-1245 167 µM 1.26543650835246 0.195275852762678 no 646 0.102857447454652 142 4016153
SGTC_1398 3558-0053 112 µM 1.26428756997906 0.195492267471831 no 647 0.10306341469983 106 4532369
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.26413167030057 0.195521644046326 no 648 0.103091385502359 121 97141
SGTC_2015 5119600 184 µM 1.26392308994121 0.195560951568412 no 649 0.103128816652254 147 2828786
SGTC_731 3966-0296 387 µM 1.26361397522416 0.195619213881343 no 650 0.10318430752087 121 660956
SGTC_805 3852-0218 479 µM 1.26349564759449 0.195641519203949 no 651 0.103205554896461 126 6615355
SGTC_270 tamoxifen 5.46 µM 1.26127001990271 0.196061348243183 no 652 0.10360578940366 142 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_855 0428-0020 25 µM 1.26067573105019 0.196173543693612 no 653 0.103712850606919 124 6812414
SGTC_2540 epiandrosterone 100 µM 1.25909353029761 0.196472436213923 no 654 0.103998275500578 136 441302 A steroid.
SGTC_2318 6029776 164 µM 1.25822463975094 0.196636695091112 no 655 0.104155263176217 136 818325
SGTC_2570 licareol 100 µM 1.25760723291869 0.196753462926646 no 656 0.10426691813632 133 443158
SGTC_471 1-acyl-paf 4 µM 1.25708888482578 0.196851528575192 no 657 0.10436072578671 122 16759367
SGTC_1045 1348-1485 165 µM 1.25092243092438 0.198020421369029 no 658 0.105481389621381 131 6810614
SGTC_440 fluspirilene 35.1 µM 1.24777861620446 0.198617962426332 no 659 0.106056070879215 131 3396 An atypical antipsychotic.
SGTC_1386 3228-0095 33.8 µM 1.24770742672315 0.19863150590413 no 660 0.106069110274953 115 870181
SGTC_2288 7946289 167.31 µM 1.24410505626738 0.199317567595255 no 661 0.106730450190328 132 1246052
SGTC_1037 k284-1091 78.7 µM 1.2439413249072 0.199348783652361 no 662 0.10676057929554 128 3334711
SGTC_170 4197-0004 226 µM 1.24367193005863 0.199400151293832 no 663 0.106810165474608 145 218692
SGTC_1158 4092-0494 91.8 µM 1.24163062214123 0.199789642485513 no 664 0.107186439053278 121 1148199
SGTC_836 0330-0104 1.35 µM 1.2393005592684 0.200234788360042 no 665 0.107617105841556 124 46494820
SGTC_1200 1643-0193 18.4 µM 1.23851049772659 0.200385860535097 no 666 0.10776341601881 146 5403974
SGTC_518 1021-0119 62.6 µM 1.2376744622379 0.200545798190379 no 667 0.10791839601482 145 1097762
SGTC_1960 st011366 51.8 µM 1.23427557901282 0.201196809983434 no 668 0.108550116349886 145 3972846
SGTC_1647 st011722 22.4 µM 1.23415547083003 0.201219838297649 no 669 0.108572488353667 139 2854783
SGTC_282 k297-0036 65.7 µM 1.23401384193017 0.201246994804371 no 670 0.108598873184444 135 5061378
SGTC_1330 1469-0054 61.8 µM 1.23233372709422 0.201569314537687 no 671 0.108912222991658 143 7102664
SGTC_1180 1193-0155 285 µM 1.22893217665817 0.202222827352308 no 672 0.10954861809426 139 2921347
SGTC_1019 4262-0212 3.4 µM 1.22517455800962 0.202946220229732 no 673 0.110254729115302 156 4677213
SGTC_856 0433-0016 11.3 µM 1.22130815900993 0.203692165739729 no 674 0.110984682683687 122 3911780
SGTC_1579 chlormadinone acetate 49.4 µM 1.22056159825568 0.203836387999245 no 675 0.111126026804251 141 45114258 A steroidal progestin.
SGTC_99 0109-0120 622.8 µM 1.2195716954217 0.204027713447124 no 676 0.111313640861575 127 759414
SGTC_1078 idebenone 36.1 µM 1.21562515029887 0.204791552722033 no 677 0.112063874475296 168 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1692 fluoroquinolonic acid 71 µM 1.21330652553351 0.205241106034804 no 678 0.112506324470465 132 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2110 5483698 200 µM 1.21266810336159 0.205364991243772 no 679 0.112628369752279 129 2848765 YHR062C RPP1
SGTC_1611 st001856 99.4 µM 1.21013867877589 0.205856260054575 no 680 0.11311284174488 154 647478
SGTC_1588 farnesol 29.9 µM 1.20989658838057 0.205903315761874 no 681 0.113159288254602 144 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1100 amiodarone 5.07 µM 1.20710464531933 0.206446453593786 no 682 0.113695923069285 116 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1370 2001-0092 44.6 µM 1.20530119145858 0.206797743934519 no 683 0.114043524915648 151 790957
SGTC_2513 baicalein 25.65 µM 1.20483103881408 0.206889381929247 no 684 0.114134267496631 152 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_379 3970-0972 5.9 µM 1.20419140093698 0.207014093070856 no 685 0.114257804413605 134 2898042 YBL034C STU1
SGTC_1496 4469-0713 57.4 µM 1.20384478160281 0.207081692533382 no 686 0.114324788752557 136 746691
SGTC_1000 4048-0884 8.67 µM 1.20216939633027 0.207408618740138 no 687 0.114648951897332 134 13040088
SGTC_2420 aureobasidin a 50 nM 1.19845989943822 0.208133555951037 no 688 0.115369012681089 119 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2966 9084041 48.03 µM 1.19389688107566 0.209027342574717 no 689 0.116259153857262 132 17741380
SGTC_1700 st030840 7.9285 µM 1.19328246863148 0.209147863779271 no 690 0.116379383037101 165 5499307
SGTC_1511 0906-3109 28.5 µM 1.19256846780905 0.209287971311954 no 691 0.116519210604718 148 2882180
SGTC_1360 1598-0022 39.8 µM 1.18949964372075 0.209890791678992 no 692 0.117121555564521 162 761525
SGTC_1447 4239-0816 81.9 µM 1.18941007368148 0.209908401564426 no 693 0.117139169333374 154 1341554
SGTC_1940 st075990 51.1 µM 1.18928096272339 0.209933786905935 no 694 0.117164562046831 141 1084979
SGTC_1240 0356-0016 42.1 µM 1.18900355782364 0.209988335381909 no 695 0.11721913344931 134 4305613
SGTC_320 4092-0846 5.34 µM 1.18884956767111 0.21001861936499 no 696 0.11724943433483 155 1359356
SGTC_458 nppb 133 µM 1.1887936934589 0.210029608323512 no 697 0.117260430163463 122 4549 A chloride channel blocker.
SGTC_2340 7987427 183.45 µM 1.18774232416041 0.210236447438117 no 698 0.117467471764188 132 2239331
SGTC_3016 9080866 49.47 µM 1.18368849154349 0.211035089474465 no 699 0.118268198126256 144 17066299
SGTC_2339 9000433 200 µM 1.18213052543579 0.211342495469583 no 700 0.118576956968696 126 2988954
SGTC_457 grayanotoxin iii 135 µM 1.18128533142575 0.211509372394094 no 701 0.118744696247693 164 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1218 1348-1416 30.7 µM 1.17976523335245 0.211809697915818 no 702 0.119046800349874 143 6787668
SGTC_3092 9117248 49.47 µM 1.1781458703636 0.21212990951268 no 703 0.119369228895234 162 17141857
SGTC_747 3448-8087 38.7 µM 1.17603262775726 0.212548205878704 no 704 0.119790919050654 137 5168703
SGTC_3004 9076122 71.4286 µM 1.17559932292363 0.212634033950159 no 705 0.119877513121732 142 44782551
SGTC_1375 2910-0797 186 µM 1.17369980918996 0.213010524227318 no 706 0.120257643359559 125 742508
SGTC_251 melphalan 456.522 µM 1.17078901352727 0.21358820815358 no 707 0.120841797487258 168 460612 A DNA alkylator.
SGTC_591 4299-0174 154 µM 1.16970902997564 0.213802776399337 no 708 0.121059041496495 144 5509088
SGTC_2683 piperine 63.03 µM 1.16954133349336 0.213836105143887 no 709 0.121092799098167 158 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2219 9098279 200 µM 1.16556616795987 0.214627032651736 no 710 0.121894946589503 108 902349
SGTC_2844 9010103 25.97 µM 1.16542859513425 0.214654435536399 no 711 0.121922774035832 152 2480525
SGTC_2210 7115885 190.385 µM 1.16381149524282 0.214976695160036 no 712 0.122250206302463 141 2927039
SGTC_628 1636-0253 16 µM 1.16288532991575 0.215161390122789 no 713 0.122438015111577 165 4456143
SGTC_329 k048-0121 21.3 µM 1.16184347383189 0.215369266066736 no 714 0.122649525703824 147 6832902
SGTC_2798 7813637 45.45 µM 1.16151283093416 0.215435261816811 no 715 0.122716704142142 184 956368
SGTC_957 1187-1561 14.1 µM 1.16129991101242 0.215477766473614 no 716 0.122759977849446 147 1538454
SGTC_2049 5262831 67.185 µM 1.15837605948914 0.216061939281779 no 717 0.123355302301621 137 763417
SGTC_1409 3909-8004 61.9 µM 1.15813807112466 0.21610952865984 no 718 0.123403847900372 141 2119279
SGTC_2748 diazoxide 86.69 µM 1.15336897843104 0.217064459957389 no 719 0.124379484357703 91 3019 A potassium channel activatior.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.15292132071732 0.217154220954997 no 720 0.124471340024878 163 688798
SGTC_3330 9141424 71.43 µM 1.15233525504618 0.217271766895008 no 721 0.12459166754227 127 27261020
SGTC_1264 0783-0040 158 µM 1.14925497847033 0.217890175219211 no 722 0.125225428321829 134 2855798
SGTC_1964 st076914 61 µM 1.14691569818452 0.218360495634027 no 723 0.125708232024406 183 24208661
SGTC_1163 k060-0048 49.9 µM 1.14492658516956 0.218760873336767 no 724 0.12611978509654 146 6809982
SGTC_632 0781-2353 4.65 µM 1.14413979680606 0.218919358200022 no 725 0.12628283277418 182 6811515 YHR007C ERG11
SGTC_1931 st074438 57.1 µM 1.14126136324713 0.219499731211972 no 726 0.126880587663932 195 2787313
SGTC_2373 9071805 200 µM 1.13980418480703 0.219793875946118 no 727 0.127183944945724 149 10149009
SGTC_402 epigallocatechin gallate 10 µM 1.13854864234514 0.220047499994059 no 728 0.127445729809142 174 65064 An antioxidant.
SGTC_512 prima-1 270 µM 1.13833207070401 0.220091265208407 no 729 0.127490923597121 127 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1189 1431-2119 7.28 µM 1.137895752775 0.220179452336778 no 730 0.127582007492013 162 3107275
SGTC_2708 st078559 56 µM 1.13703743579984 0.220352991637493 no 731 0.127761318148994 120 17250902
SGTC_364 0083-0097 67.7 µM 1.13604946927683 0.220552841239755 no 732 0.127967930592019 144 5207356
SGTC_1826 st055655 41.6 µM 1.1330807032149 0.221153998981846 no 733 0.128590182049124 136 676168
SGTC_2142 5622915 118.518 µM 1.13209923285594 0.221352946986589 no 734 0.12879635868845 129 5322196
SGTC_876 0720-0963 56.8 µM 1.13017598834818 0.221743093037191 no 735 0.129201037724542 156 765861
SGTC_2961 9083290 32.55 µM 1.12879854850769 0.222022759375455 no 736 0.129491412556077 154 17741490
SGTC_1866 st057638 64 µM 1.12316877127815 0.223167883584561 no 737 0.130682911453555 118 688802
SGTC_3223 9129970 49.47 µM 1.12222034316486 0.223361128902743 no 738 0.13088438255194 176 17248386
SGTC_395 anisomycin 6.25 µM 1.12184104120123 0.223438439560734 no 739 0.130965016331011 159 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_13 0199-0087 65 µM 1.12087635779838 0.22363513330079 no 740 0.131170247865404 168 4589825
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.11820235430641 0.22418086260009 no 741 0.131740289511204 168 279621
SGTC_3304 9125678 46.087 µM 1.11364911730259 0.225111856987684 no 742 0.132714873053046 163 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1149 3909-7961 23.3 µM 1.11283229163413 0.225279103686937 no 743 0.132890231953306 148 735261
SGTC_2628 lathosterol 100 µM 1.111811697084 0.225488171332346 no 744 0.133109560758245 152 6710616
SGTC_222 nsc-310342 10.666 µM 1.1107828107834 0.225699048654899 no 745 0.13333092354365 144 432556
SGTC_2304 7443016 91.4 µM 1.11023391457349 0.225811594329897 no 746 0.133449120981528 138 939854
SGTC_1124 fisetin 1.16336 µM 1.1084662493016 0.226174252026615 no 747 0.133830253676058 157 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3248 9135562 49.47 µM 1.10842891299857 0.226181915563759 no 748 0.133838311951524 154 17650701
SGTC_2905 7799065 20.05 µM 1.10789860323956 0.226290781189411 no 749 0.133952804449255 152 1296806
SGTC_1216 1165-0504 9.65 µM 1.1072298470113 0.226428110247264 no 750 0.134097283110859 165 6304004
SGTC_291 SEC14.278 35.5 µM 1.10694078075102 0.226487484554177 no 751 0.13415976635691 159 1068044
SGTC_2239 6685329 187.64 µM 1.10521530079788 0.226842081508151 no 752 0.134533154211051 133 805680
SGTC_569 4130-2812 160 µM 1.10387690458319 0.227117345868374 no 753 0.134823269316094 149 743552
SGTC_331 k048-0133 24.5 µM 1.10184607380135 0.227535380795587 no 754 0.135264298042357 157 6813582
SGTC_1470 k295-0292 231 µM 1.10134071085006 0.227639474163888 no 755 0.13537419952527 176 5045612
SGTC_2893 9048488 25.97 µM 1.10109659049653 0.227689767051958 no 756 0.135427310392587 171 6467338
SGTC_2008 4012253 172 µM 1.0990698355072 0.228107554028746 no 757 0.135868802980114 160 603940
SGTC_2972 9093619 59.92 µM 1.09694369835958 0.228546290165609 no 758 0.136333002352558 132 25236256
SGTC_1802 st050112 57.9 µM 1.09646484569355 0.228645168514818 no 759 0.136437699754378 146 4662563
SGTC_2587 piperic acid 92.2 µM 1.09635751336997 0.228667334875617 no 760 0.136461174673478 134 5370536
SGTC_2691 st077356 60.2 µM 1.09489858534012 0.228968753556863 no 761 0.136780534449629 166 2839272
SGTC_1899 st063254 59.6 µM 1.09475109828649 0.228999237204666 no 762 0.136812847821998 147 3093813
SGTC_2005 4024620 188 µM 1.09474400862596 0.229000702602264 no 763 0.136814401248012 162 236743
SGTC_926 2268-1401 59.4 µM 1.09458803562799 0.22903294277687 no 764 0.136848579772891 178 2931578
SGTC_3273 9137859 49.47 µM 1.09423593307967 0.229105732990516 no 765 0.136925757826404 193 2377234
SGTC_2062 5245942 200 µM 1.09153411487975 0.229664711887872 no 766 0.137518964535873 152 1376160
SGTC_1280 0880-0253 10.1 µM 1.08875395764049 0.230240694922918 no 767 0.138131200201871 170 6836607
SGTC_949 1165-0505 146 µM 1.08865373456553 0.230261473857791 no 768 0.138153305601056 159 6244267
SGTC_2951 9072950 58.06 µM 1.08629451239503 0.230750906781029 no 769 0.138674357045935 183 16488155
SGTC_1665 st014639 11.4 µM 1.08555737570701 0.230903948686279 no 770 0.138837433190009 170 981133 YIL048W NEO1
SGTC_3342 9147791 14.508 µM 1.08435156743094 0.231154416788372 no 771 0.139104474606528 165 1838168
SGTC_1503 4585-0012 61.3 µM 1.07987909745338 0.232084752115061 no 772 0.140098011221288 151 2922052
SGTC_8 0354-0001 70 µM 1.07945518234892 0.232173040307972 no 773 0.140192431334241 178 4993152
SGTC_107 0358-0022 2.6945 µM 1.07484749289804 0.233133882030757 no 774 0.141221506636423 154 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1296 1068-0102 11.9 µM 1.07390004416444 0.233331726844684 no 775 0.141433741774901 160 767053
SGTC_2040 5100729 123 µM 1.07337490620268 0.2334414254776 no 776 0.141551469408524 152 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_729 4092-0585 94.1 µM 1.07305634641035 0.233507984927134 no 777 0.141622917826724 160 2169061
SGTC_1167 k781-0610 148 µM 1.07300618294531 0.233518466972413 no 778 0.141634171002647 173 4525169
SGTC_2926 9010726 65.15 µM 1.07273092850819 0.233575988167412 no 779 0.141695929643226 159 2994293
SGTC_2741 miltefosine 3.04 µM 1.06744664166022 0.234681792102137 no 780 0.142885098118916 127 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1565 sinapyl alcohol 95.1 µM 1.06738155685236 0.2346954299449 no 781 0.142899786638277 180 5280507 A phenol propionate derived from cinnamic acid.
SGTC_608 k048-0125 159 µM 1.06723150362769 0.234726873703041 no 782 0.142933654953208 168 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_651 3253-0966 34.4 µM 1.06690627027171 0.234795034574718 no 783 0.143007081563336 170 781462
SGTC_1275 0867-0008 21.1 µM 1.06587977585335 0.235010234174866 no 784 0.143238996170629 157 3422836
SGTC_1953 st076800 12.1 µM 1.06482456726475 0.235231567101221 no 785 0.143477662768256 183 297591
SGTC_2787 5284540 71.43 µM 1.0624072981813 0.235739029560216 no 786 0.144025411014437 177 736958
SGTC_3081 9117243 49.47 µM 1.06070422016237 0.23609692254129 no 787 0.144412170749065 200 45595589
SGTC_630 4356-0227 183 µM 1.05905052888555 0.236444723406006 no 788 0.144788384196637 204 779312
SGTC_2128 5255449 168.493 µM 1.05606950025548 0.237072398832646 no 789 0.14546823177002 152 736008
SGTC_213 1246-0773 967 nM 1.05352556251485 0.23760876513614 no 790 0.146050092446852 148 6251622
SGTC_2331 7980721 200 µM 1.053053439952 0.237708381123477 no 791 0.146158250185004 188 2981221
SGTC_3112 9123419 49.47 µM 1.05282464561351 0.237756664061536 no 792 0.146210683630891 197 17015854
SGTC_2342 7990637 118.86 µM 1.05065666896755 0.238214443502962 no 793 0.146708151949223 187 2033102 YER133W GLC7
SGTC_2812 7970281 58.44 µM 1.04869108953831 0.238629902755783 no 794 0.147160158292061 177 2233435
SGTC_1671 st016596 74.5 µM 1.04837754646411 0.23869621216756 no 795 0.147232347178571 182 2829167
SGTC_1780 st038448 24.544 µM 1.04811408181586 0.238751938576843 no 796 0.14729302456125 169 728868 YDL195W SEC31
SGTC_2703 st077852 53.4 µM 1.04798305221927 0.238779655794825 no 797 0.147323207650028 183 6281836
SGTC_2218 6965428 192.983 µM 1.047850183063 0.238807763939678 no 798 0.147353818719919 158 675684
SGTC_1721 st082152 9.2685 µM 1.04688532955499 0.239011930619918 no 799 0.147576234418432 166 5296051
SGTC_2279 7948423 32.93 µM 1.04665357638867 0.239060984683058 no 800 0.147629691076189 156 1247112
SGTC_636 0kpi-0074 126 µM 1.04357602032522 0.239712917476495 no 801 0.148340796082736 167 616434
SGTC_2457 5731572 11.68 µM 1.04316776228332 0.239799473474058 no 802 0.148435300676611 178 2865357
SGTC_2803 7707263 71.43 µM 1.04279423999405 0.239878679976092 no 803 0.148521799815816 150 2199229
SGTC_319 1348-1596 45.5 µM 1.04128110811373 0.24019968999617 no 804 0.148872550999145 182 5380505
SGTC_1985 st071382 65.5 µM 1.04078477755356 0.240305037195785 no 805 0.148987723248741 182 6123237
SGTC_1885 st057546 99.9 µM 1.04077828385664 0.24030641566335 no 806 0.148989230489053 166 702008
SGTC_1688 st021091 57.6 µM 1.04027594528712 0.240413064035805 no 807 0.149105858265233 181 3656366
SGTC_2496 diffractaic acid 79.83 µM 1.03985571797184 0.240502299679178 no 808 0.149203469128585 175 94870 An apoptosis inducer which activates caspases.
SGTC_1767 st044992 70.3 µM 1.03823003766271 0.24084768412901 no 809 0.149581485718573 168 9600693
SGTC_3175 9106517 49.47 µM 1.03179048705282 0.242218448693979 no 810 0.151085138333771 178 41468073
SGTC_42 0133-0086 60.653 µM 1.02994629850746 0.242611792178805 no 811 0.151517607616377 210 162923 Model of phenazepam hydroxylation.
SGTC_1236 0330-0013 258 µM 1.02320461594283 0.24405265157336 no 812 0.153105555457328 161 4617066
SGTC_2877 9040724 71.43 µM 1.01981850918968 0.244778081414534 no 813 0.153907271626412 155 6463895
SGTC_1778 st046819 58.9 µM 1.0190122868428 0.24495097511913 no 814 0.154098566706935 214 671715
SGTC_1782 st039423 80.636 µM 1.01318345350631 0.246202916010706 no 815 0.155486271200294 163 2068169
SGTC_3228 9131799 49.47 µM 1.01223025128527 0.246407974656231 no 816 0.155713987591994 194 17015818
SGTC_1326 1431-2094 10.8 µM 1.01065518097334 0.24674701382153 no 817 0.156090747628907 184 616278
SGTC_531 3788-1495 174 µM 1.00914198473813 0.247072969485189 no 818 0.156453272578959 165 2896655
SGTC_2195 6536160 144.242 µM 1.00839465608087 0.247234035526309 no 819 0.156632518686323 157 3834386
SGTC_105 0111-0055 734.78 µM 1.00798538211884 0.247322267006508 no 820 0.156730739944984 159 5179370
SGTC_1052 3253-3998 198 µM 1.00741622883374 0.24744499332402 no 821 0.156867397855831 168 5450317
SGTC_2954 9074818 52.69 µM 1.00511144081151 0.247942306490747 no 822 0.157421595844858 190 16648742
SGTC_396 dithiazanine 1.25 µM 1.00494657104464 0.247977901519559 no 823 0.157461288878052 160 10578 An antihelmenthic.
SGTC_2026 5148700 152 µM 1.00467337731906 0.248036889460845 no 824 0.157527075801431 183 79838
SGTC_253 dyclonine 31.25 µM 1.00436697298247 0.248103057137224 no 825 0.157600881553276 166 3180 An oral anasthetic.
SGTC_1510 1123-0200 71.5 µM 1.00430309518544 0.248116852662582 no 826 0.157616271105821 203 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_203 k066-0004 30.888 µM 1.00354985489994 0.248279558906681 no 827 0.157797817559571 204 6795412
SGTC_1027 k015-0025 8.67 µM 1.00276171540415 0.248449864557653 no 828 0.157987922417093 182 3598955
SGTC_2603 homopterocarpin 100 µM 1.00004627039319 0.249037109751643 no 829 0.158644058109916 168 101795 A weak amylase inhibitor.
SGTC_3237 9133362 49.47 µM 0.997522514001424 0.249583561592326 no 830 0.159255475613275 184 43845137
SGTC_2987 9018338 71.43 µM 0.997039452578143 0.249688228186764 no 831 0.159372680152015 201 5055682
SGTC_489 paxilline 115 µM 0.996159080878058 0.24987904131757 no 832 0.159586428765699 180 105008 A toxic potassium channel blocker.
SGTC_2874 9043904 71.43 µM 0.995046252750194 0.250120348129473 no 833 0.159856884664248 188 4463428
SGTC_353 1988-1175 58.3 µM 0.992789938280248 0.250609988854072 no 834 0.16040616715789 193 2788357
SGTC_750 4073-0104 132 µM 0.991761832911557 0.25083326533058 no 835 0.160656860059138 149 22330957
SGTC_849 0386-0493 241 µM 0.991575994906065 0.2508736355177 no 836 0.160702202034205 192 726119
SGTC_61 0978-8327 98.565 µM 0.989731385833146 0.251274532297381 no 837 0.161152714949961 178 6150059 YHR072W ERG7
SGTC_626 0214-0009 33 µM 0.989265465812688 0.251375846246323 no 838 0.161266637848244 198 3437874
SGTC_207 4185-0010 4.486 µM 0.987970948087997 0.25165745142883 no 839 0.161583438265509 189 3761753
SGTC_1604 st002052 72.4 µM 0.98764837149911 0.251727649616932 no 840 0.161662443815074 165 6254834 YHR062C RPP1
SGTC_1694 st024011 44.9 µM 0.987171018475681 0.251831548776604 no 841 0.16177940344383 197 2787533
SGTC_2315 7733312 200 µM 0.98649160586311 0.25197946662437 no 842 0.16194596618575 176 726316
SGTC_141 0443-0274 32.331 µM 0.980950314988877 0.253187594758403 no 843 0.163308621788508 172 1627241
SGTC_420 mitomycin C 81.9 mM 0.979642688362058 0.253473130859862 no 844 0.163631262671128 186 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.979168768736554 0.253576658707656 no 845 0.163748298652045 183 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2806 7952793 58.44 µM 0.978400070690914 0.253744628189893 no 846 0.163938246629074 183 2972490
SGTC_2295 7971645 200 µM 0.976473982426057 0.254165757369921 no 847 0.164414817435437 175 2978226 YKL099C UTP11
SGTC_774 k060-0086 136 µM 0.974517827174847 0.254593835418536 no 848 0.164899745979457 188 5911235
SGTC_477 mead ethanolamide 10 µM 0.97376679601932 0.254758288676426 no 849 0.16508617153255 130 16061185
SGTC_3201 9113999 49.47 µM 0.972113001258263 0.255120616019576 no 850 0.165497167424418 169 16649224
SGTC_7 0192-1582 4.227 µM 0.971898874028705 0.255167548523467 no 851 0.165550430006733 225 252616
SGTC_1266 0828-0227 32.9 µM 0.96937016175563 0.255722134144043 no 852 0.166180267120819 192 3913820
SGTC_197 4544-0043 41.561 µM 0.967614452977371 0.256107558007528 no 853 0.166618478195842 197 896523
SGTC_1677 st019204 53.9 µM 0.967612491125955 0.256107988854472 no 854 0.166618968275261 168 3945625
SGTC_2814 7977482 42.97 µM 0.967343838531028 0.256166991871918 no 855 0.166686087703468 197 6456762
SGTC_2705 st078069 42.8 µM 0.961403907971142 0.257473362033209 no 856 0.16817456005005 171 1530061
SGTC_3241 9133421 49.47 µM 0.961022055136423 0.257557461243225 no 857 0.168270539255042 209 17018221
SGTC_387 norethindrone acetate 66.7 µM 0.959464727731653 0.257900594475254 no 858 0.168662340311719 182 541197
SGTC_1396 3511-0007 98.6 µM 0.958936759282291 0.258016978046727 no 859 0.168795302522664 190 X1396
SGTC_3014 9081533 49.47 µM 0.957543557067572 0.258324221544133 no 860 0.169146486236565 219 21367265
SGTC_1501 4491-0275 38.4 µM 0.952453944838016 0.259448245268601 no 861 0.170433406163106 196 5104718
SGTC_1488 4013-0813 75.9 µM 0.952085782757774 0.259529650491182 no 862 0.170526739354728 186 2910057
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.951792636138828 0.259594478291686 no 863 0.170601078690292 193 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3157 9099274 49.47 µM 0.951117669195637 0.259743775386618 no 864 0.170772323082068 189 17217662
SGTC_3280 9140961 49.47 µM 0.950829241481023 0.259807586717778 no 865 0.170845532985801 211 4901226
SGTC_2140 5586273 200 µM 0.950341462624201 0.259915520611526 no 866 0.170969388707187 179 854421
SGTC_1751 st044839 27.194 µM 0.949475364413385 0.26010722458432 no 867 0.171189447945738 182 5291326
SGTC_3041 9091929 49.47 µM 0.949130811379075 0.260183508928821 no 868 0.171277042717608 183 25236887
SGTC_232 clozapine 119 µM 0.941747666675721 0.261820910073486 no 869 0.173160922205046 190 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2502 avocadyne acetate 18.59 µM 0.940345645769878 0.262132440135868 no 870 0.173520146522031 185 3952079
SGTC_2033 5192550 145 µM 0.939570792079598 0.262304694653046 no 871 0.173718882055243 190 182073
SGTC_1021 4476-0760 85.3 µM 0.937884971605556 0.26267966260889 no 872 0.174151763584961 174 746768
SGTC_279 1273-0055 2.93 µM 0.934258575784642 0.263487190700587 no 873 0.17508526339869 220 2847562
SGTC_1213 1315-0166 115 µM 0.933319307472654 0.263696553955606 no 874 0.175327564639553 185 768401
SGTC_1608 st001473 40.5 µM 0.932152102345305 0.263956842601345 no 875 0.175628962413927 236 7292267
SGTC_115 0527-0192 112.043 µM 0.931715852845436 0.264054160557877 no 876 0.175741695767072 235 4233931
SGTC_375 3970-0961 9.27 µM 0.931179345812869 0.264173868893138 no 877 0.175880399996509 204 2898222
SGTC_1460 k062-0059 9.15 µM 0.930928781716279 0.264229785570209 no 878 0.175945202574996 190 1373085
SGTC_2298 7976326 193.81 µM 0.930717183939891 0.264277011093788 no 879 0.175999939194447 166 2235818
SGTC_1121 fusaric acid 630.51 nM 0.925160058657776 0.265518816732716 no 880 0.177441328126028 176 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3217 9129673 49.47 µM 0.920990699010095 0.266452449361067 no 881 0.178527641507148 206 17248312
SGTC_1184 1269-1718 139 µM 0.920572821548243 0.266546114932581 no 882 0.178636748629854 198 5403821
SGTC_1241 0364-0022 50.8 µM 0.920380956315033 0.266589126338913 no 883 0.178686858391395 212 4563895
SGTC_1740 st038286 13.222 µM 0.920006036848987 0.266673184073001 no 884 0.178784802272809 204 716786
SGTC_1602 st001878 87.6 µM 0.919824508442724 0.266713887937741 no 885 0.178832236855815 224 595405 YLR310C CDC25
SGTC_1970 st070122 35.8 µM 0.91923633077882 0.266845795774827 no 886 0.178985986012244 222 102928
SGTC_2478 5763493 32.33 µM 0.917497370890653 0.267235976817709 no 887 0.179441034990994 209 1365576 YLR208W SEC13
SGTC_1431 4049-0260 9.09 µM 0.917385642716259 0.267261055790375 no 888 0.179470296732569 218 3854841
SGTC_453 enantio-paf c16 10 µM 0.916179377743565 0.26753189467262 no 889 0.179786409951371 233 13871343 A lipid and platelet activating factor
SGTC_1607 st000305 50.6 µM 0.914842937684452 0.267832122867948 no 890 0.180137044952723 200 5457690
SGTC_2927 9011802 47.9 µM 0.913835389709102 0.268058578367871 no 891 0.180401673813146 208 43912568
SGTC_2464 5717415 7.67 µM 0.91151412575283 0.268580669962825 no 892 0.181012273121544 200 5285744
SGTC_1989 st071868 50.2 µM 0.91048768654002 0.268811696386837 no 893 0.18128268631913 210 16414057
SGTC_3114 9122766 49.47 µM 0.909459578637487 0.26904319840071 no 894 0.181553792581823 169 17176985
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.908476620517512 0.269264627436099 no 895 0.181813230249394 192 94937 An inhibitor of serotonin biosynthesis.
SGTC_3334 9142812 21.919 µM 0.907460867406429 0.269493540122261 no 896 0.182081567191351 192 45283678
SGTC_2752 diclazuril 33.15 µM 0.905522810841616 0.269930575860357 no 897 0.182594240435334 198 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.905268224271175 0.269988012004278 no 898 0.182661653031134 213 5282362
SGTC_528 3492-0019 172 µM 0.904909419705504 0.270068970689097 no 899 0.182756688144046 221 2869262
SGTC_2945 9067681 61.76 µM 0.903605062858805 0.270363380872103 no 900 0.183102427863189 252 16456930
SGTC_2960 9079389 5.97 µM 0.903212121749584 0.27045210418773 no 901 0.183206662832876 176 16457355
SGTC_3312 9133330 71.43 µM 0.901375379175323 0.270867020493159 no 902 0.183694383762246 214 17617324
SGTC_139 0099-0334 718.624 µM 0.900603807608012 0.271041411602714 no 903 0.183899504704989 218 97690
SGTC_3106 9121286 49.47 µM 0.899991277063459 0.271179896023299 no 904 0.18406244640062 188 15943471
SGTC_2082 5219693 150 µM 0.899955585077006 0.271187966560012 no 905 0.184071943738849 201 2834649
SGTC_2047 4141938 200 µM 0.898476128340581 0.271522601030765 no 906 0.184465883142744 235 3807862
SGTC_3035 9091303 49.47 µM 0.898453671679188 0.271527682028708 no 907 0.184471866783292 208 25237002
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.898156634186353 0.271594893575308 no 908 0.184551024617567 214 165521
SGTC_2822 7994718 71.43 µM 0.896797746410862 0.271902478706989 no 909 0.1849134253627 237 1018011
SGTC_824 1304-0008 100 µM 0.896492136136846 0.271971677652416 no 910 0.184994989205968 218 768245
SGTC_679 0422-0091 41.4 µM 0.896489832777172 0.271972199232471 no 911 0.184995604030854 240 627384 YHR062C RPP1
SGTC_89 0302-0250 142.109 µM 0.895482752967129 0.272200293221169 no 912 0.185264540690207 226 4203518 YLR208W SEC13
SGTC_3115 9123671 49.47 µM 0.894310483337227 0.272465920822863 no 913 0.185577896237633 223 3286988
SGTC_3061 glucosamine 200 µM 0.890311327305364 0.273373067407412 no 914 0.18664937027123 190 91431 and experimental redox chemotherapeutic
SGTC_742 0kpi-0133 140 µM 0.887087706028737 0.274105382988289 no 915 0.187515841224779 219 2728852
SGTC_1789 tunicamycin 25 nM 0.886061265220561 0.274338764574566 no 916 0.187792257194882 215 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1843 st055809 45.5 µM 0.885009215718277 0.27457807055923 no 917 0.188075830474987 212 16413835
SGTC_942 3253-1115 227 µM 0.884258621598538 0.274748868473269 no 918 0.188278309829689 229 46497897
SGTC_554 4483-2211 187 µM 0.879798755268177 0.275764791351761 no 919 0.189484169550724 207 747107
SGTC_40 0327-0103 19.753 µM 0.87849730619618 0.276061598923896 no 920 0.189836949473481 198 409036
SGTC_537 1334-0398 209 µM 0.875703971171637 0.276699174094884 no 921 0.190595492965653 218 5846986
SGTC_301 4119-0100 24.5 µM 0.874537992003827 0.276965520637367 no 922 0.190912669841963 225 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2045 5106652 78.05 µM 0.874395176219958 0.276998152908816 no 923 0.190951541723062 201 673349
SGTC_3262 9137218 49.47 µM 0.872888220441158 0.277342594986258 no 924 0.191362003737685 178 17650664
SGTC_341 1486-1430 230 µM 0.87080658773583 0.277818734097965 no 925 0.191929883831922 246 2054753 YPL210C SRP72
SGTC_2755 lomerizine 42.69 µM 0.870426825321577 0.27790564150711 no 926 0.19203359611662 202 3949 A calcium channel blocker.
SGTC_2506 ethyl hematommate 54.16 µM 0.869107117244999 0.278207755602946 no 927 0.192394272096986 203 3940691 An allergen.
SGTC_3188 9110789 49.47 µM 0.868481968123355 0.278350923709177 no 928 0.192565269727542 212 849217
SGTC_2800 7887935 81.82 µM 0.867791144679883 0.278509173930722 no 929 0.192754339328067 212 2961002
SGTC_2080 5212524 12.4 µM 0.866198017470476 0.278874286176518 no 930 0.193190790192027 235 260183
SGTC_1712 st032288 53.4 µM 0.865394172993603 0.279058599288437 no 931 0.193411239072746 226 2883011
SGTC_292 k038-0015 474 µM 0.864242638629519 0.279322737214488 no 932 0.193727306818862 222 46368540
SGTC_1333 1482-0047 286 µM 0.863977517046703 0.279383567765698 no 933 0.193800120719266 215 3811116
SGTC_811 0416-0114 265 µM 0.863889811412882 0.279403692711899 no 934 0.193824212167095 212 6612453
SGTC_2167 5876490 200 µM 0.862544876818746 0.279712389739795 no 935 0.194193874515811 223 686534
SGTC_114 0364-0001 490.298 µM 0.859846338613395 0.280332272276933 no 936 0.194936875932171 226 4003655
SGTC_2247 cerulenin 830 nM 0.859354092048009 0.280445418181743 no 937 0.195072594710596 216 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1397 3532-0190 20.1 µM 0.857695230999251 0.280826880312849 no 938 0.195530387048264 187 5322280
SGTC_3055 9094636 49.47 µM 0.854177026002129 0.281636735719118 no 939 0.196503455270803 237 25236176
SGTC_1125 tnp00248 1.32998 µM 0.854047437982602 0.28166658706982 no 940 0.196539352781455 243 24207736
SGTC_1468 k284-1086 134 µM 0.85355334429497 0.281780418407202 no 941 0.196676259397728 222 15996457
SGTC_964 1287-0107 19.4 µM 0.85318546716256 0.281865185852764 no 942 0.196778230636128 202 51516812 YPR165W RHO1
SGTC_2920 7982904 15.77 µM 0.851178569730224 0.282327837918034 no 943 0.197335082676014 214 6456808
SGTC_495 decylubiquinone 155 µM 0.850044028337322 0.282589546429729 no 944 0.197650304139377 215 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1422 4031-0024 15.5 µM 0.847714066471855 0.283127372004079 no 945 0.198298615298354 246 782427
SGTC_1497 4476-2978 41.3 µM 0.846656932434952 0.283371552343863 no 946 0.198593185280442 207 1528379
SGTC_1126 isoteolin 1.0172 µM 0.842535122792724 0.28432458477427 no 947 0.199744244224293 208 133323
SGTC_1369 1866-0067 208 µM 0.840440770761521 0.284809420790534 no 948 0.200330648781884 218 3531355
SGTC_2520 obtusaquinone 4.71 µM 0.839452441202231 0.285038352952965 no 949 0.200607733280416 229 5967872
SGTC_1435 4092-0789 56.7 µM 0.839256425439922 0.285083767576503 no 950 0.20066271488185 233 2248285
SGTC_1716 st033144 30.6155 µM 0.838728036755945 0.285206206406404 no 951 0.200810970752716 221 674617
SGTC_3046 9092212 49.47 µM 0.838171476927034 0.285335200178199 no 952 0.200967201980591 238 25236637
SGTC_3243 9134147 49.47 µM 0.837822212587427 0.285416163300488 no 953 0.201065280773505 243 24282180
SGTC_3205 9113483 49.47 µM 0.836317983778235 0.28576498421122 no 954 0.201488019318349 225 17018033
SGTC_438 sphingosine 6.67 µM 0.835744350108354 0.285898059527307 no 955 0.201649369717677 208 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_535 2293-4129 48.2 µM 0.834602228393379 0.286163104136196 no 956 0.201970853533843 250 396118 YIL048W NEO1
SGTC_3028 9087778 49.47 µM 0.833769464181669 0.286356431747258 no 957 0.202205452842159 220 17217395
SGTC_2477 5967686 25.23 µM 0.830941596908936 0.287013388196704 no 958 0.203003311604692 215 776118
SGTC_3315 9136395 68.55 µM 0.824872078887108 0.288425834555571 no 959 0.20472210978878 259 16876844
SGTC_2395 5646831 180.19 µM 0.823978263369043 0.288634112122623 no 960 0.204975954427929 232 6808628
SGTC_1961 st076550 68.7 µM 0.82247243031568 0.288985162602877 no 961 0.205404035671235 249 1579337
SGTC_3007 9078383 71.4286 µM 0.82186541357756 0.28912673143491 no 962 0.205576749656079 224 6496995
SGTC_1819 st053448 58.6 µM 0.821018537184561 0.28932429495895 no 963 0.205817854709918 256 2857616
SGTC_468 gf-109203x 121 µM 0.818365634325161 0.289943587553011 no 964 0.206574219321936 198 2396 A protein kinase C inhibitor.
SGTC_3353 9151644 39.2805 µM 0.817494796530724 0.29014701100869 no 965 0.206822860863731 214 4909158
SGTC_2924 9010168 62.78 µM 0.817254585973574 0.290203134787385 no 966 0.206891476924768 229 2993929
SGTC_234 nsc-17383 10.7 µM 0.817034468041662 0.29025456850811 no 967 0.206954365362941 215 408974
SGTC_2221 6807166 181.081 µM 0.814419262999573 0.29086597525866 no 968 0.207702403524861 213 674925
SGTC_2084 5306078 60.6385 µM 0.811354239263528 0.291583310032771 no 969 0.208581135113811 249 679340
SGTC_1763 st044482 94.5 µM 0.810317153740599 0.291826215018428 no 970 0.208878959458213 254 88505
SGTC_940 3232-1287 54.8 µM 0.809965096032744 0.291908694999708 no 971 0.208980118327961 226 1585493 YIL048W NEO1
SGTC_2069 5228469 200 µM 0.808479020023116 0.292256972052843 no 972 0.209407439393194 250 2835210
SGTC_2421 5690543 90.72 µM 0.807053466059471 0.292591246679686 no 973 0.209817840113607 241 3397993
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.806736332676765 0.292665634651271 no 974 0.209909203446584 230 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_560 2332-1943 155 µM 0.804827999333847 0.293113445700511 no 975 0.210459470938441 248 21177716
SGTC_305 1682-2595 20.8 µM 0.8037076742188 0.293376490054358 no 976 0.210782910501737 241 226033
SGTC_619 1652-1634 108 µM 0.80097496908218 0.294018568091187 no 977 0.211573068440401 231 5400454
SGTC_1794 st048918 76.9 µM 0.800556063721699 0.294117051743624 no 978 0.211694347453256 198 672303
SGTC_405 ebelactone b 50 µM 0.800220551412145 0.294195940881484 no 979 0.211791512339113 229 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2932 9016711 44.54 µM 0.799602610858425 0.294341263058603 no 980 0.211970537158798 227 7117328
SGTC_1456 k015-0012 13 µM 0.799548705422123 0.294353941667548 no 981 0.211986158409036 246 2989616
SGTC_195 4234-0266 16.654 µM 0.798470505516766 0.29460758824007 no 982 0.212298751229233 257 2303354
SGTC_1267 0828-0272 9.49 µM 0.798345226095615 0.29463706676673 no 983 0.212335089828546 234 745334
SGTC_263 alizarin 107.927 µM 0.797255461255731 0.294893548235204 no 984 0.212651340753041 255 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1487 3970-0795 2.82 µM 0.796772526088473 0.295007242275658 no 985 0.212791576964502 239 3765103
SGTC_2623 humulene 100 µM 0.795063598815824 0.295409725108647 no 986 0.213288253891198 226 6187145 An anti-inflammatory.
SGTC_1519 esterone 74 µM 0.793520485774862 0.295773372616765 no 987 0.213737319328014 230 698 A steroid.
SGTC_2106 5357045 167.29 µM 0.792084198196784 0.296112030493236 no 988 0.214155791607932 222 668842
SGTC_427 1354-0053 47.3 µM 0.791957591913473 0.296141891135102 no 989 0.21419270207079 233 6813657
SGTC_2979 9012552 45.46 µM 0.788266058336073 0.297013162123188 no 990 0.215270548367802 262 17100905
SGTC_2882 9058044 58.44 µM 0.788160655601907 0.297038056348155 no 991 0.215301369787567 240 18076804
SGTC_2714 st079313 56.9 µM 0.786172780880198 0.297507735110522 no 992 0.215883135058014 228 2939799
SGTC_325 2810-4341 181 µM 0.78322542894024 0.298204734654887 no 993 0.216747372357976 233 774970
SGTC_959 1222-0044 107 µM 0.7830582428577 0.298244293653038 no 994 0.216796455388157 239 6083612
SGTC_2695 st077686 51.995 µM 0.782959705621744 0.298267610315495 no 995 0.216825387278145 242 2876092
SGTC_1259 0671-0132 43 µM 0.782665540929327 0.298337222835628 no 996 0.216911771362726 233 X1259
SGTC_2558 carylophyllene oxide 100 µM 0.782622471792372 0.298347415539974 no 997 0.216924420668158 255 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2576 guaiol 23.12 µM 0.781536222617105 0.298604538718595 no 998 0.217243590488202 230 227829
SGTC_841 0251-0215 91.2 µM 0.779991854323234 0.298970275450976 no 999 0.217697834906992 239 3888614
SGTC_3207 9114163 49.47 µM 0.779705889279112 0.299038019905591 no 1000 0.217782005778225 264 849233
SGTC_1214 0358-0031 63.7 µM 0.77958704987389 0.299066174734597 no 1001 0.21781699045655 244 4301366
SGTC_1120 ficusin 1.78878 µM 0.77937447882074 0.299116538991582 no 1002 0.217879576520662 239 6199 A DNA cross-linker.
SGTC_2999 9069765 71.4286 µM 0.776998870437454 0.29967965135791 no 1003 0.218579718378672 221 2097066
SGTC_1682 st012968 530 nM 0.775424600967441 0.300053079328574 no 1004 0.219044401498951 214 24207270
SGTC_929 2805-0021 398 µM 0.772704465320912 0.30069881052621 no 1005 0.219848651703602 259 3098024
SGTC_906 1165-0455 526 µM 0.770541933323545 0.301212619611393 no 1006 0.22048924530089 249 3252859
SGTC_3002 9075603 71.4286 µM 0.770503566143536 0.30122173907183 no 1007 0.220500620224164 253 20105405
SGTC_1432 4049-0298 68.4 µM 0.769466148983722 0.30146836895059 no 1008 0.220808316294469 252 741646
SGTC_4 0960-0234 25.671 µM 0.767212921836006 0.302004351619865 no 1009 0.221477465668493 239 6821112
SGTC_2889 9059656 51.95 µM 0.765638836287457 0.302379038351819 no 1010 0.221945614793669 257 3949838
SGTC_744 1594-0068 283 µM 0.765091711557532 0.302509321748872 no 1011 0.222108467518258 253 668392
SGTC_2773 thioridazine 9.09 µM 0.763454106487239 0.302899424718228 no 1012 0.222596311190666 258 5452 An antipsychotic.
SGTC_1295 1013-0063 9.78 µM 0.760457393901385 0.303613870639887 no 1013 0.223490613784121 252 6826038
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.759455926302616 0.303852798037432 no 1014 0.223789934668072 240 641818 YHR062C RPP1
SGTC_1810 st050138 53 µM 0.756748640688712 0.304499114227562 no 1015 0.224600233894045 273 3444541
SGTC_312 4092-0653 6.84 µM 0.754347759900702 0.305072792977517 no 1016 0.225320215573333 249 1148278
SGTC_721 1187-1332 279 µM 0.754203587237312 0.305107257601616 no 1017 0.225363491962574 258 25730
SGTC_1865 st057639 52.2 µM 0.752237544030837 0.305577414654699 no 1018 0.225954109736869 264 688818
SGTC_2325 6158266 200 µM 0.75189971590925 0.30565823475378 no 1019 0.226055684499275 246 3623240
SGTC_3017 9080681 49.47 µM 0.75101113962601 0.305870857942295 no 1020 0.226322975865487 260 16451914
SGTC_1583 clindamycin 39.6 µM 0.749322953856741 0.306274996123152 no 1021 0.226831288071643 261 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2884 9058502 51.95 µM 0.749304923888525 0.306279313627013 no 1022 0.226836720363139 249 6471554
SGTC_920 mycophenolic acid 780.421 nM 0.748873767361759 0.306382567520999 no 1023 0.226966646386167 242 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2620 irigenin 100 µM 0.746809774204905 0.306877068008904 no 1024 0.227589197379895 253 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3091 9116372 49.47 µM 0.744177085115843 0.307508329376098 no 1025 0.228384674576437 246 17169793
SGTC_694 1315-0438 43.2 µM 0.743541628098743 0.307660783637733 no 1026 0.228576914182083 252 6793154
SGTC_2486 5283202 22.39 µM 0.742258429473456 0.307968740646179 no 1027 0.228965386679454 250 1377751
SGTC_2783 7738165 71.43 µM 0.739971897376423 0.308517824562188 no 1028 0.229658523288282 265 17201110
SGTC_613 3914-0030 117 µM 0.738380458147525 0.308900243072554 no 1029 0.230141643142978 242 1145395
SGTC_616 4092-0450 108 µM 0.735781596442037 0.309525187919643 no 1030 0.230931811426926 281 787165
SGTC_2572 astragaloside iv 100 µM 0.735350411921606 0.309628927651265 no 1031 0.231063056834392 256 45006101 An anti-inflammatory agent.
SGTC_95 0471-0001 561.058 µM 0.731605271138302 0.31053061746821 no 1032 0.232204765001777 253 4015405
SGTC_3246 9135460 32.98 µM 0.731118306289597 0.310647944225319 no 1033 0.232353446789665 268 41446951
SGTC_2448 5185112 27.17 µM 0.730282965498857 0.310849251709762 no 1034 0.232608619220963 242 5718189
SGTC_1768 st044301 37.178 µM 0.728252193326153 0.311338880432809 no 1035 0.233229610578923 291 3931349
SGTC_857 0438-0306 1.35 µM 0.727556310731104 0.311506737864936 no 1036 0.233442616532861 255 4686136
SGTC_316 k060-0003 58.6 µM 0.727437322801661 0.311535443481421 no 1037 0.233479048904568 256 6152314
SGTC_1935 st074532 41.6 µM 0.727247712020797 0.311581189096548 no 1038 0.233537111481791 266 2829742
SGTC_854 0422-0053 192 µM 0.726904644050474 0.311663965280167 no 1039 0.233642186039532 280 3596728
SGTC_2291 7917025 104.35 µM 0.7266374742835 0.31172843517313 no 1040 0.233724032713466 250 2964612
SGTC_3052 9092717 49.47 µM 0.726175713143509 0.311839874900888 no 1041 0.233865529348664 276 25237534
SGTC_2711 st079103 59.1 µM 0.726173256862467 0.311840467736757 no 1042 0.233866282149342 255 54693780
SGTC_776 4476-4378 112 µM 0.726161373580162 0.311843335834011 no 1043 0.233869924155041 290 2892008
SGTC_2314 7727897 200 µM 0.725003457966061 0.312122860006483 no 1044 0.234224954513524 249 900724
SGTC_3040 9091894 49.47 µM 0.723247570903397 0.312546942626323 no 1045 0.234763898682199 232 25236966
SGTC_1951 sophoraflavanone G 9.2 µM 0.721620815990343 0.312940058839028 no 1046 0.235263818784714 250 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2365 9042475 200 µM 0.721608381067005 0.312943064641515 no 1047 0.235267642438923 264 6464479
SGTC_217 ketoconazole 989 nM 0.717390824053125 0.31396325988794 no 1048 0.236566489927536 245 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1998 st075797 76.8 µM 0.714963554645533 0.314551044042795 no 1049 0.237315781858 264 24208315
SGTC_1997 st073024 93.8 µM 0.712408898090473 0.315170184147447 no 1050 0.238105803540591 265 686268
SGTC_2327 6189656 200 µM 0.711756528854111 0.315328374054019 no 1051 0.238307778005428 277 5349088
SGTC_804 1595-0054 20.9 µM 0.709736457230783 0.315818426251244 no 1052 0.238933789880593 259 761523 Stimulates phospholipase C.
SGTC_382 3229-0966 23.2 µM 0.709544759003753 0.315864947452284 no 1053 0.23899324305221 272 5722370
SGTC_1916 st067606 49.2 µM 0.707397716200336 0.316386189539271 no 1054 0.239659677883906 253 19590279
SGTC_2135 5326629 150.42 µM 0.706462340646424 0.316613386829957 no 1055 0.239950332165924 265 5020077
SGTC_1157 4092-0394 27.6 µM 0.706347588327078 0.3166412642696 no 1056 0.239986003005646 270 3659885
SGTC_2324 6149169 200 µM 0.703234690134075 0.317397895396147 no 1057 0.240954751914879 257 2888231
SGTC_954 1189-0853 2.85 µM 0.702216210169414 0.317645616395025 no 1058 0.241272168950745 278 2828194
SGTC_858 0438-0351 2.77 µM 0.701929743741172 0.31771530725205 no 1059 0.241361489321958 269 2799119
SGTC_3331 9141060 1.957 µM 0.701882713482197 0.317726749276535 no 1060 0.241376155096143 255 4906567 YPR165W RHO1
SGTC_374 0880-0231 82.3 µM 0.699599947057821 0.318282334220866 no 1061 0.242088587816973 271 6833587
SGTC_1421 4029-0249 71.4 µM 0.696938029417979 0.318930714417986 no 1062 0.242920788472967 282 2894095
SGTC_1859 st055998 20 µM 0.696420644403468 0.319056801597389 no 1063 0.243082719051868 280 676301
SGTC_1303 1160-0052 261 µM 0.69552330265377 0.31927553420801 no 1064 0.243363706426134 265 3562476
SGTC_2568 diosmetin 100 µM 0.695327117958861 0.31932336382698 no 1065 0.243425161714434 287 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_888 0916-0002 6.97 µM 0.694329945080924 0.319566519978237 no 1066 0.243737657897314 258 2802138 YIL048W NEO1
SGTC_1713 st033146 12.748 µM 0.693904500389182 0.319670286386123 no 1067 0.243871050550561 280 674619
SGTC_1123 mangostin 811.285 nM 0.693132505937013 0.319858612691845 no 1068 0.24411319994316 223 5281650 An antioxidant.
SGTC_2872 9044037 25.97 µM 0.693114753696273 0.319862943857377 no 1069 0.244118769764793 267 6465195
SGTC_1208 2323-2347 50.3 µM 0.693070633224035 0.319873708411532 no 1070 0.244132612999212 265 5412760
SGTC_2733 amorolfine 100 µM 0.692485020828176 0.320016601038048 no 1071 0.244316394770988 295 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1313 1220-0047 237 µM 0.691005758422386 0.320377668042948 no 1072 0.244780961146752 265 3528706
SGTC_2942 9052777 62.25 µM 0.690907673983769 0.320401615082343 no 1073 0.244811781632821 305 6469503
SGTC_3303 9125618 40.5795 µM 0.688925004640411 0.320885838442238 no 1074 0.245435231572256 259 22695467
SGTC_2828 7998861 71.43 µM 0.68496593497612 0.321853665599627 no 1075 0.246682708616484 226 2988188
SGTC_2629 bisabolol 100 µM 0.684025807116112 0.322083665589476 no 1076 0.246979434878113 294 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2775 cyproheptadine 69.59 µM 0.680086065071564 0.323048254327993 no 1077 0.248224983659652 278 2913 A selective serotonin reuptake inhibitor.
SGTC_2835 9006588 71.43 µM 0.680048995416775 0.323057335962545 no 1078 0.248236719110512 243 2345538
SGTC_542 3381-0244 89.3 µM 0.678723490062679 0.32338213865129 no 1079 0.248656539786844 294 1112843
SGTC_2824 7998404 51.95 µM 0.678160008979644 0.323520255220998 no 1080 0.248835122811704 296 837851
SGTC_1416 3966-0321 25.3 µM 0.67667159429482 0.323885202005189 no 1081 0.249307171529202 271 582530 YLR208W SEC13
SGTC_892 0929-0076 29 µM 0.676210837117651 0.323998210142809 no 1082 0.249453396491927 272 5751038
SGTC_455 paf C-16 10 µM 0.675977333313386 0.324055486915641 no 1083 0.249527518183917 270 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1415 3966-0071 78.1 µM 0.675793241336469 0.324100646265612 no 1084 0.249585963205624 280 2893185
SGTC_2793 7325131 81.82 µM 0.675767916814411 0.324106858791869 no 1085 0.249594003735202 267 4176441
SGTC_2417 cerulenin 830 nM 0.675461056765603 0.324182140555241 no 1086 0.249691442660434 280 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_952 1185-0122 232 µM 0.675298672868789 0.324221980993124 no 1087 0.249743013467124 272 678600
SGTC_2768 sulfasalazine 50.2 µM 0.675286787654094 0.32422489707658 no 1088 0.249746788263708 293 5384001 An antioxidant and salicylic acid derivative.
SGTC_318 1488-0629 67.2 µM 0.672219192882479 0.324977903431302 no 1089 0.250722082082536 292 3662576
SGTC_85 0868-0259 160.055 µM 0.669483986477772 0.325649921622235 no 1090 0.251593396196267 262 83173
SGTC_1006 4099-6547 255 µM 0.668317113832757 0.325936785520502 no 1091 0.251965595680523 294 3146833
SGTC_1816 st051957 91.6 µM 0.667793005697698 0.326065665784125 no 1092 0.252132865920278 290 674121
SGTC_1082 camptothecin 424.86 nM 0.666257818336581 0.32644329396006 no 1093 0.252623161127827 291 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1837 st055472 66.5 µM 0.666219132273425 0.326452812328315 no 1094 0.252635522840692 269 676091
SGTC_1391 3442-0225 151 µM 0.663262648061517 0.327180563385223 no 1095 0.253581177182542 275 5227075
SGTC_910 3454-3003 490 µM 0.660729362584936 0.327804665533365 no 1096 0.254392944957359 292 820824
SGTC_3173 9105693 49.47 µM 0.660407303483033 0.327884042777155 no 1097 0.25449624329444 304 17096658
SGTC_2272 7805186 180 µM 0.659773387990148 0.328040305337833 no 1098 0.254699631699962 311 2956062 YPR165W RHO1
SGTC_1043 0916-0009 19.3 µM 0.659228646782915 0.32817461015157 no 1099 0.254874476984864 304 3101130
SGTC_1417 3966-0327 90.4 µM 0.657567190238218 0.328584375959001 no 1100 0.255408141517376 293 651118
SGTC_3120 9124077 49.47 µM 0.65742788300398 0.328618742744492 no 1101 0.255452913912679 302 18774327 YGL155W CDC43
SGTC_1173 0443-0020 122 µM 0.655199836638686 0.329168593670233 no 1102 0.256169549753599 286 5331295
SGTC_2826 7992541 19.48 µM 0.654325967425124 0.329384353485443 no 1103 0.256450909740864 335 2985066
SGTC_582 0987-0078 156 µM 0.652612050320555 0.329807687533801 no 1104 0.257003207466077 298 1625765
SGTC_2916 7875993 68.79 µM 0.645217777929184 0.331636552316138 no 1105 0.259393033476781 310 1299250
SGTC_3172 9105863 49.47 µM 0.645101714208325 0.331665291135668 no 1106 0.25943063653097 284 2348785
SGTC_23 0213-0011 39.996 µM 0.643899620422592 0.33196300274298 no 1107 0.259820263975957 302 627608
SGTC_1879 gemcitabine 100 µM 0.643857452763891 0.331973447950137 no 1108 0.259833937005247 316 60750 A nucleoside analog which inhibits DNA replication.
SGTC_853 0419-0306 21 µM 0.643810838781941 0.331984994692846 no 1109 0.259849052204356 291 762713
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.643130800181993 0.3321534650946 no 1110 0.26006961527065 295 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2104 5389443 200 µM 0.641574190921578 0.332539221742642 no 1111 0.26057484752182 294 2244536
SGTC_3089 9117425 49.47 µM 0.640108704365985 0.332902558649262 no 1112 0.261050965234746 311 9401657
SGTC_2385 9074692 200 µM 0.63882019941068 0.333222146334293 no 1113 0.261469953079417 279 17046906
SGTC_145 3737-0113 38.366 µM 0.637017694762245 0.33366942450433 no 1114 0.262056658903669 284 6849351
SGTC_784 4579-0127 173 µM 0.63632865967734 0.333840465970477 no 1115 0.262281114360948 298 1948547
SGTC_1340 1486-1359 257 µM 0.632125498069712 0.33488457736059 no 1116 0.263652437459042 292 4309068
SGTC_3024 9090631 49.47 µM 0.626373036571567 0.336315621658921 no 1117 0.265535145454561 273 25236383
SGTC_2636 apigenin dimethyl ether 100 µM 0.626270936206861 0.336341042754735 no 1118 0.265568623107789 308 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1590 st077108 57.8 µM 0.625343274065356 0.336572047681459 no 1119 0.265872891984512 265 5489485
SGTC_129 0088-0017 176.636 µM 0.623804342661178 0.336955405918053 no 1120 0.266378043667599 289 182446
SGTC_2070 5230947 200 µM 0.623262895429665 0.337090324401966 no 1121 0.266555888240919 315 2835538
SGTC_2996 9066192 71.4286 µM 0.622103483344518 0.337379298594836 no 1122 0.26693691232571 286 6472854
SGTC_1373 2887-0003 58.5 µM 0.618628399821867 0.338246009580701 no 1123 0.268080594140738 304 776948
SGTC_2019 4016004 108 µM 0.614675302900467 0.3392329834653 no 1124 0.26938458651148 298 45595336
SGTC_2472 5377652 49.4 µM 0.614017120385435 0.339397419988829 no 1125 0.269602006973766 319 1610903
SGTC_1691 st019933 84.6 µM 0.611898899928959 0.339926831443675 no 1126 0.270302324749117 323 6176082
SGTC_1817 st052116 64.4 µM 0.610489726834621 0.340279204169457 no 1127 0.270768723298146 285 4361398
SGTC_2087 5276107 200 µM 0.610214131574445 0.340348134843663 no 1128 0.270859984894422 296 144405
SGTC_1876 myriocin 605 nM 0.609973506077223 0.34040832339688 no 1129 0.270939679030074 331 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2176 5809774 33.9695 µM 0.608979399997032 0.340657025935674 no 1130 0.271269046675111 286 2870539
SGTC_1419 3993-2473 62.6 µM 0.608605751305253 0.340750522189764 no 1131 0.271392895701194 303 704026
SGTC_2094 5332512 191.667 µM 0.608061143008714 0.340886814337534 no 1132 0.271573461181155 298 755774
SGTC_269 exalamide 29 µM 0.607937144214916 0.340917848831999 no 1133 0.271614581477387 296 3316 A derivative of salicylamide.
SGTC_2192 5915882 198.485 µM 0.606771657272537 0.341209600208875 no 1134 0.272001229973682 297 2876149
SGTC_2956 9076196 2.52 µM 0.606741224077455 0.341217219693584 no 1135 0.272011329805114 322 16423868
SGTC_725 1497-0963 19 µM 0.605547417014504 0.341516161303566 no 1136 0.272407664345133 297 3549977
SGTC_3227 9130768 49.47 µM 0.605276030549076 0.341584133155647 no 1137 0.2724978025105 317 17720899
SGTC_1190 1486-1332 13 µM 0.602935052160308 0.342170671130753 no 1138 0.273275948228672 304 4150046
SGTC_3285 9112818 20.8695 µM 0.602636506926305 0.342245499805258 no 1139 0.273375264317014 304 17017947 YPR165W RHO1
SGTC_492 tmb-8 126 µM 0.602542439209053 0.342269078630121 no 1140 0.273406561226345 308 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2992 9074591 71.4286 µM 0.598642550386031 0.34324715715538 no 1141 0.274705637476491 311 17741321
SGTC_972 1319-0219 195 µM 0.597500137612028 0.343533869608333 no 1142 0.275086757572797 308 23903702
SGTC_1526 st051518 75 µM 0.596398309665737 0.34381048175794 no 1143 0.275454584711258 305 673993
SGTC_971 1315-0384 26.7 µM 0.595011869620189 0.344158664136384 no 1144 0.275917768422881 329 6769120
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.591766181017569 0.344974283623413 no 1145 0.277003586234578 319 229346 A bile salt which induces apoptosis.
SGTC_598 3937-0236 20.2 µM 0.589588593597426 0.345521900851285 no 1146 0.277733250344718 323 1379313
SGTC_2203 7227154 166.4 µM 0.587912153974161 0.345943710440196 no 1147 0.278295629030256 298 896304
SGTC_430 0958-0115 16.4 µM 0.586409565285927 0.346321939888837 no 1148 0.27880015895788 317 6833180
SGTC_681 1642-0006 26.6 µM 0.585852540600325 0.346462192307456 no 1149 0.278987306295905 327 4446530
SGTC_506 n9-isopropylolomoucine 153 µM 0.584497777189627 0.346803394010567 no 1150 0.279442730156303 302 6610355
SGTC_2083 5306046 65.942 µM 0.584267810875193 0.346861324143354 no 1151 0.279520072584307 301 539837
SGTC_2335 9018011 154.17 µM 0.583032545496779 0.347172557416719 no 1152 0.279935695653942 303 6458208
SGTC_945 3381-0768 11.3 µM 0.582839618080132 0.347221176068163 no 1153 0.280000635946172 314 1126236 YIL048W NEO1
SGTC_927 2425-1185 123 µM 0.57966194910539 0.348022325414941 no 1154 0.281071304053169 337 730375
SGTC_1292 0kpi-0043 232 µM 0.579016420290086 0.348185158289064 no 1155 0.281289046811717 318 3333905
SGTC_977 1348-1378 135 µM 0.577676556084075 0.348523224677654 no 1156 0.281741254985751 305 X977
SGTC_103 0844-0104 51.839 µM 0.577040675496943 0.348683708327726 no 1157 0.28195598913751 314 5375804
SGTC_2426 5582046 32.21 µM 0.576393541913864 0.348847059815412 no 1158 0.282174604288371 310 2251934
SGTC_2238 6671620 73.2395 µM 0.574581103414141 0.349304710277896 no 1159 0.282787317511324 282 729941
SGTC_1860 st056228 74.6 µM 0.574064256196207 0.349435257172555 no 1160 0.282962159999898 346 688679
SGTC_446 go6976 132 µM 0.573836957534759 0.349492674622825 no 1161 0.283039068519444 318 3501 A protein kinase C inhibitor.
SGTC_2072 5231554 129 µM 0.572797469010538 0.34975530156347 no 1162 0.283390916493557 309 789545
SGTC_2343 7990716 14.84 µM 0.570816446231032 0.350256006304572 no 1163 0.284062036725387 325 6456862
SGTC_1337 1486-1011 40.3 µM 0.563213403444801 0.352180090788921 no 1164 0.286644788484534 308 X1337
SGTC_90 0870-0863 4.608 µM 0.563119178926782 0.352203959846536 no 1165 0.286676866270183 350 1738164
SGTC_606 k015-0008 38.6 µM 0.562097297492286 0.352462861345199 no 1166 0.287024864771438 331 1970475
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.56152928250994 0.352606801869501 no 1167 0.287218386958347 322 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1804 st050076 49.1 µM 0.561469119889636 0.352622048899477 no 1168 0.287238887924706 308 3895976
SGTC_225 nsc-122657 1.016 µM 0.561106598273631 0.352713927866612 no 1169 0.287362435157601 320 275685
SGTC_3021 9087658 49.47 µM 0.56084979543119 0.352779018232742 no 1170 0.287449968680312 317 25237042
SGTC_1088 bifonazole 369 nM 0.560453432684831 0.352879490518169 no 1171 0.287585097178513 306 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2563 tomatine 8.54 µM 0.558863229051862 0.353282687482894 no 1172 0.288127533136602 371 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_925 2064-1272 59.6 µM 0.556845633189137 0.353794487030848 no 1173 0.288816451295435 329 6815817
SGTC_677 0929-0063 136 µM 0.55447377459976 0.35439648971318 no 1174 0.289627324415574 333 1539583
SGTC_189 3970-0742 2.116 µM 0.554470618560747 0.354397290991907 no 1175 0.289628404089984 334 2891807
SGTC_2282 7944268 200 µM 0.549089683653278 0.355764377507872 no 1176 0.291471952307545 319 2970414
SGTC_206 4546-0025 72.014 µM 0.548798324008154 0.355838453830886 no 1177 0.291571930301631 334 6620745 YIL048W NEO1
SGTC_1457 k015-0032 57.3 µM 0.548747782974126 0.355851304119075 no 1178 0.291589274726056 325 4302660
SGTC_1073 triclabendazole 3.09 µM 0.546113586166984 0.356521287078237 no 1179 0.292493930656989 313 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2789 5281112 71.43 µM 0.545010203682853 0.356802053707058 no 1180 0.292873249932798 313 765948
SGTC_549 1661-1316 519 µM 0.543586270688165 0.357164502261762 no 1181 0.293363104800276 344 2857282
SGTC_755 1995-0008 37.3 µM 0.541971940821105 0.357575570455391 no 1182 0.293918917862072 304 689533
SGTC_2032 5185112 25.99 µM 0.541606442135303 0.357668662925512 no 1183 0.294044826479137 299 5718189
SGTC_2118 5526350 200 µM 0.541069823963004 0.357805354848893 no 1184 0.294229728260809 329 743594
SGTC_973 1325-0077 65.9 µM 0.538053782005725 0.358573965431524 no 1185 0.295269959558562 332 2835149
SGTC_2481 5478948 45.16 µM 0.536766781786466 0.358902120283844 no 1186 0.295714359928465 315 77792
SGTC_2173 5763948 167 µM 0.53333545262522 0.359777537181706 no 1187 0.296900695215057 327 2867177
SGTC_478 N-arachidonylglycine 10 µM 0.533246318516055 0.359800287325936 no 1188 0.29693154111882 299 5283389
SGTC_2432 5630864 12.22 µM 0.531298508028912 0.360297560641263 no 1189 0.297605969565246 338 5714970
SGTC_901 1112-0062 60.1 µM 0.531158776224234 0.360333243075915 no 1190 0.297654378501768 310 1908457
SGTC_1049 3226-0134 66 µM 0.53103498247071 0.360364856526741 no 1191 0.297697268833008 321 5702385
SGTC_175 3793-3120 23.7 µM 0.53033649512326 0.360543248478823 no 1192 0.297939323800838 349 5322297
SGTC_3272 9137413 49.47 µM 0.526307585699128 0.361572813503956 no 1193 0.299337256658205 334 17614870
SGTC_2982 9019404 25.97 µM 0.524797594243554 0.361958942104113 no 1194 0.299861952059838 291 22333232
SGTC_2715 st079500 56.4 µM 0.523967327401045 0.362171314327938 no 1195 0.300150632435492 321 28246688
SGTC_2184 6075246 200 µM 0.523350643317154 0.362329082132237 no 1196 0.300365132268955 324 2267320
SGTC_1981 st071826 47 µM 0.523336289186066 0.36233275466347 no 1197 0.300370125858788 320 11838600
SGTC_2372 9071633 200 µM 0.520942827965731 0.362945303142543 no 1198 0.301203299639314 315 21321366
SGTC_3057 9095946 49.47 µM 0.519924556619541 0.363206011519034 no 1199 0.301558079515889 333 24540043
SGTC_2212 7123476 200 µM 0.519118982583689 0.363412307845879 no 1200 0.301838885820388 324 1085715
SGTC_1363 1636-0063 10.4 µM 0.516546411970434 0.364071372490833 no 1201 0.30273641607566 333 6072185
SGTC_307 1501-1223 22.3 µM 0.516470538287023 0.364090816620257 no 1202 0.302762905375222 341 2830329
SGTC_3163 9099914 49.47 µM 0.51602867287416 0.364204060306932 no 1203 0.302917191676112 360 16268368
SGTC_324 1315-0088 19.6 µM 0.5158556479962 0.36424840730081 no 1204 0.302977616420529 354 6787421
SGTC_2293 7624732 200 µM 0.513504148794093 0.364851286277826 no 1205 0.303799354709073 326 894453
SGTC_1948 st076329 66.6 µM 0.512932296030281 0.36499794887351 no 1206 0.303999340543699 335 24208413
SGTC_2673 kobusone 100 µM 0.511452593121102 0.365377538665941 no 1207 0.304517087933547 349 6710676 An epoxy ketone and protein crosslinker.
SGTC_2232 chlorophetanol 41.5365 µM 0.50899644680424 0.366007907591381 no 1208 0.305377357348378 334 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1112 tnp00069 1.16933 µM 0.50886025260401 0.366042872380362 no 1209 0.305425091124577 345 145826
SGTC_1618 st003135 44.5 µM 0.508806502789129 0.366056671739151 no 1210 0.305443930441024 352 1270615
SGTC_3059 1327-0034 3 µM 0.508112598130286 0.366234835611905 no 1211 0.305687190352571 320 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_277 nystatin 15.5 µM 0.504957525810973 0.367045281100987 no 1212 0.30679433431408 360 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_609 0986-0026 86.3 µM 0.503361654089184 0.367455439721344 no 1213 0.307355013197625 333 2848610
SGTC_159 3970-0959 50 µM 0.499332241212516 0.368491720440581 no 1214 0.308772672675235 341 6615653
SGTC_2236 dapsone 200 µM 0.495988946835415 0.369352272862314 no 1215 0.309951104678826 322 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1318 1280-3875 124 µM 0.495178423682927 0.369560997536442 no 1216 0.310237089792121 341 373245
SGTC_2455 5377712 9.75 µM 0.494387093472422 0.369764816766478 no 1217 0.310516413624481 308 2243908
SGTC_1539 benzyladenosine 56 µM 0.492952847607556 0.370134322015545 no 1218 0.311022952382697 301 92208 A nucleotide analog.
SGTC_187 1488-2104 32.728 µM 0.492224128129148 0.37032210821737 no 1219 0.311280454668127 341 2852859
SGTC_431 k089-0097 107 µM 0.491696477212208 0.370458099673817 no 1220 0.311466964491735 329 5499420
SGTC_1941 st076221 61.8 µM 0.491448637673282 0.370521980940739 no 1221 0.311554585535221 317 2828568
SGTC_757 1066-0008 322 µM 0.490909646246468 0.37066091966511 no 1222 0.311745177083575 340 6842497
SGTC_179 1273-0063 6.77 µM 0.490555868697505 0.370752123981395 no 1223 0.311870302988035 369 3108139
SGTC_1830 st055982 50.3 µM 0.487248165203378 0.371605205048687 no 1224 0.313041238098114 374 455313 An antimicrobial agent.
SGTC_1004 4084-0029 199 µM 0.486978729979992 0.371674722221713 no 1225 0.313136702145748 362 716894 YLR208W SEC13
SGTC_9 0092-0002 10.449 µM 0.485058211052133 0.372170357775273 no 1226 0.313817526994547 350 759368
SGTC_1410 3909-8106 77.9 µM 0.484714383985878 0.372259112903425 no 1227 0.313939480871911 363 1039210
SGTC_816 0325-0417 81.3 µM 0.480720204099185 0.37329066214025 no 1228 0.315357684807846 355 68101
SGTC_2723 salbutamol 83.58 µM 0.480313321373817 0.373395796057542 no 1229 0.315502308954012 352 9884233 β2-adrenoceptor agonist
SGTC_1097 itavastatin 7.23 µM 0.479423989338898 0.373625622250792 no 1230 0.31581851534506 349 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_911 3456-4043 236 µM 0.479190847310429 0.373685879566632 no 1231 0.315901432460236 350 914281
SGTC_1342 1486-1464 234 µM 0.478879192162193 0.373766434013058 no 1232 0.316012287286191 347 3253938
SGTC_308 4092-1169 104 µM 0.478519518436293 0.373859406820439 no 1233 0.316140242745576 361 2268590 YDL196W YDL196W
SGTC_1448 4255-0083 152 µM 0.477809854767591 0.374042870777233 no 1234 0.316392773203934 378 5399660
SGTC_1936 st074407 74.3 µM 0.476987653832297 0.374255463817919 no 1235 0.316685456601893 339 809813
SGTC_3167 9103034 49.47 µM 0.476801702300648 0.374303549828842 no 1236 0.316751666717561 341 5127859
SGTC_445 e6 berbamine 66 µM 0.476563476167276 0.374365156612318 no 1237 0.316836498365697 336 6610268 A calcium/calmodulin antagonist.
SGTC_2909 7941780 10.49 µM 0.474726992164143 0.374840190557229 no 1238 0.317490788130232 339 1243215
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.471547048060927 0.375663179347561 no 1239 0.318625065124966 369 61125 An anti-inflammatory.
SGTC_1481 3346-2004 36 µM 0.471380672924388 0.375706253854728 no 1240 0.318684457596554 374 2770522
SGTC_283 0987-0079 11.7 µM 0.470522473068729 0.375928466310044 no 1241 0.318990891093225 360 411556
SGTC_529 4076-0302 30.3 µM 0.469441747903667 0.376208355453376 no 1242 0.319376956723148 347 5816522
SGTC_1265 0819-1001 68.8 µM 0.468064259833946 0.376565195439228 no 1243 0.319869318416729 386 3106768
SGTC_2105 5350118 200 µM 0.467394267989526 0.376738795810657 no 1244 0.320108911418974 347 2133313
SGTC_1853 st056710 91.2 µM 0.466561555161869 0.376954593261187 no 1245 0.320406798978202 374 269167
SGTC_2193 5925765 200 µM 0.466105540539189 0.377072785702316 no 1246 0.320569978808718 334 877370
SGTC_1463 k081-0032 34.1 µM 0.465339428658394 0.377271376825133 no 1247 0.3208442016181 340 977755
SGTC_2650 prasterone 100 µM 0.464299229165555 0.377541068746505 no 1248 0.321216688090317 334 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.461549161301287 0.378254364589445 no 1249 0.322202329574534 332 6312947
SGTC_256 clotrimazole 625 nM 0.459196829416977 0.378864827622512 no 1250 0.323046413598422 344 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_480 am 92016 50 µM 0.459097116156117 0.378890711298222 no 1251 0.323082213751557 380 2129 K+ channel blocker.
SGTC_877 0771-0151 33.1 µM 0.458604361424048 0.379018629074404 no 1252 0.323259152038057 355 6166523
SGTC_3290 9121031 71.43 µM 0.457663085404516 0.379263018566632 no 1253 0.323597256398214 344 17014854
SGTC_442 cape 100 µM 0.457356890624469 0.379342528276249 no 1254 0.323707272331647 357 5281787
SGTC_3221 9128209 49.47 µM 0.45627947493123 0.379622341753949 no 1255 0.324094510752715 366 16460723
SGTC_1161 k007-0610 110 µM 0.454317980939195 0.380131919234842 no 1256 0.324799988039716 355 5843850
SGTC_17 0960-0276 49.807 µM 0.453609213288685 0.380316101569541 no 1257 0.325055060518392 350 6821114
SGTC_48 0382-0018 55 µM 0.452815520680476 0.380522384950736 no 1258 0.32534079327717 318 762596
SGTC_2995 9067767 71.4286 µM 0.452420521631337 0.380625059199849 no 1259 0.325483032923132 350 11673567
SGTC_2847 9005661 71.43 µM 0.44804150823166 0.381763881769259 no 1260 0.32706162016158 343 2991449
SGTC_878 0828-0289 13.7 µM 0.446219993882312 0.382237893752762 no 1261 0.327719170877857 355 745350 YLR208W SEC13
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.442756127407814 0.383139780950467 no 1262 0.328971069993587 344 803109
SGTC_1471 k673-0312 37 µM 0.442704738052417 0.383153165984253 no 1263 0.328989657458168 348 24099884
SGTC_1625 st003711 30.1 µM 0.442540544976488 0.38319593316614 no 1264 0.329049048719036 353 24207034 YER133W GLC7
SGTC_2617 dihydrotanshinone i 20.83 µM 0.441616154113983 0.383436734746872 no 1265 0.329383496179427 333 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_133 0724-0033 378.92 µM 0.44076523887369 0.383658435916005 no 1266 0.329691480646663 357 280309
SGTC_335 4077-0256 27.6 µM 0.437240267720879 0.384577252264762 no 1267 0.330968554734895 365 3121989
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.433135722545089 0.385647957242387 no 1268 0.332458086086513 396 5393153
SGTC_1956 st077085 54 µM 0.432976083577965 0.385689618071655 no 1269 0.33251607243248 381 24208685
SGTC_2144 5628481 200 µM 0.430617440746408 0.386305304279215 no 1270 0.333373278822018 344 2818399
SGTC_1118 chelidonine 707.474 nM 0.428784351957485 0.386784000826053 no 1271 0.334040083794627 366 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_371 0195-0006 7.36 µM 0.428262537356184 0.386920300091584 no 1272 0.334229995193389 345 3928593
SGTC_2321 7390090 138.78 µM 0.424541711549547 0.387892592344092 no 1273 0.335585396047175 368 649046
SGTC_2860 9025725 38.96 µM 0.42335245296215 0.388203507155062 no 1274 0.336019064891059 379 40546248
SGTC_162 k030-0015 37.8 µM 0.422678457046279 0.388379745668726 no 1275 0.336264937724495 392 1809920 YMR134W ERG29
SGTC_1606 st000094 49.2 µM 0.422449482078237 0.388439623975981 no 1276 0.336348483442124 371 1242210
SGTC_1867 st057372 64 µM 0.421762405470064 0.388619314478183 no 1277 0.336599224442135 356 688837
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.417969260547645 0.389611760175493 no 1278 0.337984796072445 344 6708739 YPR165W RHO1
SGTC_3063 1327-0034 4 µM 0.417864129657404 0.389639277110676 no 1279 0.338023229993557 380 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_194 1486-1323 56.904 µM 0.417809856920219 0.389653482661034 no 1280 0.338043071769546 372 5178754
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.416373851791009 0.390029401543504 no 1281 0.338568229633066 374 688751
SGTC_2153 5569715 200 µM 0.415130266755417 0.390355031631648 no 1282 0.339023271837241 398 2054701
SGTC_2829 7992743 58.44 µM 0.413894374854103 0.3906787235132 no 1283 0.339475731835569 348 16462845
SGTC_2648 atorvastatin 78.68 µM 0.412391639030594 0.391072406425647 no 1284 0.340026195211297 392 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2769 toremifene 3.73 µM 0.408563004780179 0.392075925988565 no 1285 0.341430192381469 355 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2855 9016525 58.44 µM 0.40774473890916 0.392290494242209 no 1286 0.341730544033455 377 43811474
SGTC_199 4063-0024 41.6 µM 0.407689834952174 0.392304892503932 no 1287 0.34175070060156 378 306215
SGTC_3019 9081971 49.47 µM 0.407354263079131 0.392392897591642 no 1288 0.341873906941803 375 16451803
SGTC_3098 9119039 49.47 µM 0.406923852560758 0.39250578255518 no 1289 0.342031958263524 355 17161528
SGTC_2815 7968870 71.43 µM 0.404972813702446 0.393017600232237 no 1290 0.342748747300603 378 2977326 YHR190W ERG9
SGTC_2474 5321570 43.32 µM 0.404853692480539 0.393048855404525 no 1291 0.342792529430511 411 2841384
SGTC_1058 3448-5425 97.3 µM 0.404283122189651 0.393198571894111 no 1292 0.343002267618348 380 7279705
SGTC_2788 5282734 71.43 µM 0.404000136100196 0.393272832732975 no 1293 0.343106309547037 387 743706
SGTC_2512 diallyl trisulfide 49.23 µM 0.402527909004297 0.393659235234597 no 1294 0.343647776491248 402 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2747 doxorubicin 7.63 µM 0.402099119245118 0.39377179562467 no 1295 0.343805540469163 363 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2052 5265182 7.135 µM 0.40174301104552 0.393865283330866 no 1296 0.343936583507634 393 1239884
SGTC_2836 9010338 19.48 µM 0.401504101365975 0.393928006792444 no 1297 0.344024509572996 343 2994051
SGTC_741 4582-0002 126 µM 0.399971912194975 0.394330333816197 no 1298 0.344588602347679 380 2912688
SGTC_3104 9120930 49.47 µM 0.399532450947038 0.394445749753389 no 1299 0.344750458840665 391 17014836
SGTC_655 k060-0012 42 µM 0.39891066973496 0.394609064307726 no 1300 0.344979513533396 407 5994525
SGTC_875 0709-0210 25.7 µM 0.396769266912306 0.395171658156178 no 1301 0.34576880795063 377 6251364
SGTC_2242 6630449 61.2675 µM 0.395956261657408 0.395385309917908 no 1302 0.34606864744006 377 691249 YDR170C SEC7
SGTC_1622 st003707 19.4 µM 0.395618193748302 0.395474160922507 no 1303 0.346193356622696 379 10140899
SGTC_244 nsc-207895 1.295 µM 0.395456709189623 0.39551660421049 no 1304 0.346252932220316 367 42640
SGTC_33 0986-0033 35.816 µM 0.395107469543831 0.395608399756025 no 1305 0.346381788264945 366 2848082
SGTC_2222 6885208 172.143 µM 0.394630032818135 0.395733900504288 no 1306 0.346557972886784 375 609514
SGTC_1862 st057513 3.81 µM 0.39216661810674 0.396381614149842 no 1307 0.347467553739796 368 5393163
SGTC_601 0986-0029 62.9 µM 0.388884688828141 0.397244986705226 no 1308 0.348680724490841 390 24747981
SGTC_652 0437-0092 114 µM 0.385194997894236 0.398216229927494 no 1309 0.35004647453571 354 3091274
SGTC_2263 7948595 193.29 µM 0.383883259439898 0.39856167327377 no 1310 0.350532487274845 391 2971371
SGTC_3070 9117005 49.47 µM 0.383327542442272 0.39870804407273 no 1311 0.35073846006462 377 8779016
SGTC_2403 6032726 181.2 µM 0.382115590584361 0.399027310554887 no 1312 0.351187814048738 354 2881040
SGTC_1087 pterostilbene 9.05 µM 0.382080105283612 0.399036659525423 no 1313 0.351200974031702 382 5281727 Similar to reservatol, lowers cholesterol.
SGTC_295 k015-0027 31 µM 0.381766526103798 0.399119277729483 no 1314 0.351317274914377 379 3887424
SGTC_3309 9129340 25.759 µM 0.378711385621397 0.399924446659136 no 1315 0.352451098787255 360 17158987
SGTC_1743 st037606 46.3785 µM 0.37857849177768 0.399959479936266 no 1316 0.352500448212206 341 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2505 galangin 7.89 µM 0.377747532677159 0.400178554384052 no 1317 0.352809076742595 419 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_732 3970-1727 52.7 µM 0.374406106735199 0.401059805974679 no 1318 0.354051100143733 409 1275699
SGTC_1286 0929-0070 131 µM 0.372038564589002 0.401684515272879 no 1319 0.354932068261631 366 1420408
SGTC_401 neomycin 50 µM 0.371994198004551 0.401696224424179 no 1320 0.354948584597708 365 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_347 4534-1311 26.2 µM 0.371749443234341 0.401760821260752 no 1321 0.355039704287114 372 2862016
SGTC_233 rapamycin 362 pM 0.371432392464679 0.401844502789719 no 1322 0.355157751360957 360 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2394 5221648 200 µM 0.369373611504611 0.402388001238531 no 1323 0.355924632209687 390 788586
SGTC_3039 9090270 49.47 µM 0.368830398197773 0.402531435860587 no 1324 0.356127072581753 380 17173750
SGTC_3140 9094243 49.47 µM 0.368366284905045 0.402653994643845 no 1325 0.35630006673162 413 19291112
SGTC_2443 5493264 126.67 µM 0.368086824415615 0.402727796623353 no 1326 0.356404247441596 396 5340055
SGTC_1648 st011736 69.8 µM 0.365625410009494 0.403377974460333 no 1327 0.357322305807944 375 2855514
SGTC_3344 9148862 3.898 µM 0.365040573758508 0.403532497168272 no 1328 0.357540559749018 391 4905352
SGTC_1376 2910-0861 41.3 µM 0.364552296295425 0.40366151910029 no 1329 0.35772281479449 384 1112859
SGTC_1268 0828-0275 2.46 µM 0.363143012193026 0.404033965626861 no 1330 0.358249027736159 385 745337
SGTC_515 4092-1064 102 µM 0.361769565622725 0.404397024713778 no 1331 0.358762118482109 412 717353
SGTC_1881 5652484 16 µM 0.36002702372261 0.404857769531457 no 1332 0.35941346237468 407 2255129
SGTC_2595 hexamethylquercetagetin 100 µM 0.35618039398448 0.405875321601384 no 1333 0.360852736876449 422 386331
SGTC_2382 9035899 200 µM 0.355522024453054 0.406049544583122 no 1334 0.361099274048392 425 6462679
SGTC_1053 3366-3204 134 µM 0.354912753944375 0.406210791169175 no 1335 0.361327476712225 385 3632071 YPR165W RHO1
SGTC_2801 7907800 81.82 µM 0.354276301189886 0.406379248666114 no 1336 0.361565913205847 414 6620925
SGTC_2997 9067075 71.4286 µM 0.353241649664222 0.406653139126308 no 1337 0.361953642996144 427 27209819
SGTC_1302 1159-0335 255 µM 0.353237289115862 0.406654293536905 no 1338 0.361955277387091 394 649284
SGTC_921 1561-0023 372 µM 0.352400743161075 0.406875775519967 no 1339 0.36226887236314 371 24050882
SGTC_2175 5807670 165.306 µM 0.351472082087481 0.407121680575077 no 1340 0.362617106708383 373 241186
SGTC_1568 digitonin 820 nM 0.351424721668773 0.407134222371771 no 1341 0.362634869222863 416 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2259 7964009 200 µM 0.35141926782592 0.407135666642741 no 1342 0.362636914704392 354 313134
SGTC_1012 4112-3522 18 µM 0.349967892411921 0.407520060522755 no 1343 0.363181396954565 379 3112398
SGTC_1041 0206-0046 107 µM 0.349053137301498 0.407762377367291 no 1344 0.363524708738985 388 50494
SGTC_969 1313-0238 134 µM 0.348928917631324 0.407795285639184 no 1345 0.363571337410923 401 5212874
SGTC_2130 NSC 7 2.4545 µM 0.348746799605434 0.407843533518007 no 1346 0.363639703198001 381 21448
SGTC_68 0986-0284 82.829 µM 0.34754307288502 0.408162467657966 no 1347 0.364091682591473 347 423278 YIL048W NEO1
SGTC_2541 muurolladie-3-one 83.07 µM 0.346937435689739 0.408322957650905 no 1348 0.364319160851927 427 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_551 k048-0028 34.9 µM 0.345839888086871 0.40861383993424 no 1349 0.364731523175078 402 6836383
SGTC_657 3534-0529 86.7 µM 0.345265101996918 0.408766195194253 no 1350 0.36494753996707 404 1049549
SGTC_3209 9113616 49.47 µM 0.344883020390814 0.408867479009492 no 1351 0.365091158056827 423 16649353
SGTC_633 0437-0093 97.7 µM 0.343533050265189 0.409225383518816 no 1352 0.36559874070748 394 2831118
SGTC_1933 st074711 15.9 µM 0.34291845864571 0.409388349333686 no 1353 0.365829902417163 388 17250958
SGTC_761 k216-0224 480 µM 0.34123253868199 0.409835470110803 no 1354 0.366464264693588 433 1340404
SGTC_1219 1469-0211 33.1 µM 0.340938190610564 0.409913545844866 no 1355 0.366575056722898 440 6822282
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.340819983583977 0.409944901227181 no 1356 0.366619552742591 400 616764
SGTC_2518 prenyletin 46.28 µM 0.339756118001533 0.410227126180155 no 1357 0.367020098405984 374 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2846 9008642 19.48 µM 0.339183681095526 0.410379002942822 no 1358 0.367235680992856 424 2992898
SGTC_3 0833-0587 95.581 µM 0.338567923677941 0.410542388342988 no 1359 0.367467625031874 381 5382644
SGTC_502 l-744,832 89.3 µM 0.338230511825212 0.410631923969692 no 1360 0.367594742136645 431 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3079 9117512 49.47 µM 0.336387068106766 0.411121182405179 no 1361 0.368289500022292 448 7185044
SGTC_1737 st035557 69.7 µM 0.334815419290112 0.411538414459188 no 1362 0.36888216414028 389 5716916
SGTC_1065 prochlorperazine maleate 2.48 µM 0.333993973881518 0.411756526783672 no 1363 0.369192052986692 425 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.333834689821042 0.411798823460784 no 1364 0.369252152468988 396 688788
SGTC_2842 9000675 19.48 µM 0.333449248065358 0.411901178842293 no 1365 0.369397596751243 398 2989072
SGTC_589 1227-0070 34.1 µM 0.332950606627561 0.412033603680545 no 1366 0.369585784031343 394 2841384
SGTC_2581 avocatin a 64 µM 0.332042070103032 0.412274910620306 no 1367 0.369928746019331 405 6710728 A skin care supplement.
SGTC_999 SEC7.066 22.7 µM 0.331752264842826 0.412351889763831 no 1368 0.370038165919873 399 740511 YDR170C SEC7
SGTC_2647 atorvastatin 60.16 µM 0.331647561777528 0.412379702208064 no 1369 0.370077700567579 406 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_72 0744-0168 198.391 µM 0.331054736462315 0.412537183647838 no 1370 0.370301570324245 438 677577
SGTC_620 0109-0052 432 µM 0.32932807510443 0.412995943792795 no 1371 0.370953862866596 402 493037
SGTC_2444 5485484 36.41 µM 0.327235074329539 0.413552196684096 no 1372 0.371745047216939 417 6790631
SGTC_1352 1496-0991 99 µM 0.326720711625623 0.413688924502484 no 1373 0.371939566801914 436 3000039
SGTC_668 1682-0499 62.6 µM 0.325777620024011 0.413939644146951 no 1374 0.372296306218955 394 682214
SGTC_2159 5658611 73.75 µM 0.32574168571645 0.413949197929162 no 1375 0.37230990111284 422 793844
SGTC_2907 7721985 69.9 µM 0.323100081444335 0.414651655072587 no 1376 0.373309724291694 378 3267881
SGTC_2692 st077426 47.7 µM 0.323015976875256 0.414674024711407 no 1377 0.373341571162077 442 25238571
SGTC_406 estrone 100 µM 0.322713725075391 0.414754418151737 no 1378 0.373456028373267 419 5870 A steroid.
SGTC_1947 st076332 61.6 µM 0.321934626876696 0.414961660451876 no 1379 0.373751110024601 442 24208416
SGTC_2838 9002687 71.43 µM 0.320296518307463 0.415397479041814 no 1380 0.374371781120153 408 6457060
SGTC_1531 st059297 52.4 µM 0.319940634300361 0.415492175723403 no 1381 0.374506666902768 384 7566702
SGTC_220 paclitaxel 373.376 µM 0.319167820525522 0.415697829563778 no 1382 0.374799628666017 416 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_981 1488-1094 54.9 µM 0.318362699630854 0.415912105226221 no 1383 0.375104914422007 386 3449522
SGTC_947 3447-0010 211 µM 0.318302036448661 0.415928251198477 no 1384 0.375127919861295 416 748350
SGTC_369 0957-0393 4.5 µM 0.317092973489971 0.416250082163571 no 1385 0.375586528168244 394 6997992
SGTC_2269 7935389 174.42 µM 0.317010867306406 0.416271939401956 no 1386 0.375617678155544 418 97605
SGTC_703 3875-0075 71.8 µM 0.316947665978121 0.41628876421246 no 1387 0.375641656446008 422 2850814
SGTC_2665 lovastatin 100 µM 0.316679801410059 0.416360074077493 no 1388 0.375743288350141 403 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2532 xanthone 78.9 µM 0.314254874495678 0.41700575369801 no 1389 0.376663734124489 419 7020 An insecticide.
SGTC_1367 1812-0510 76.9 µM 0.313870572803387 0.417108101411282 no 1390 0.376809670634645 386 1142582 YDR527W RBA50
SGTC_2731 amoxapine 43.43 µM 0.313464797747634 0.417216174034899 no 1391 0.376963780646244 435 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1564 D-Arginine 115 µM 0.313181483166276 0.417291634698582 no 1392 0.377071392805307 407 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_556 4058-0063 51.5 µM 0.312376358750305 0.417506095710701 no 1393 0.377377257532192 423 6615692
SGTC_1957 st077035 62.4 µM 0.311302502040132 0.417792177135896 no 1394 0.377785332685792 428 705593
SGTC_3206 9114350 49.47 µM 0.310324156081526 0.418052851845572 no 1395 0.378157231687414 428 17087243
SGTC_1800 st050079 29.0735 µM 0.309800852583404 0.418192297869432 no 1396 0.378356201611146 408 3645560
SGTC_935 2996-0153 430 µM 0.309551730428386 0.418258685702563 no 1397 0.378450933920727 412 23738523
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.308976427511796 0.418412005386729 no 1398 0.378669729098877 398 5377381
SGTC_2543 pimpinellin 60.67 µM 0.305146366284773 0.419433041305491 no 1399 0.380127339453964 425 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.303454380504736 0.419884272159592 no 1400 0.380771804209447 428 551469
SGTC_264 promethazine 12.5 mM 0.302300750417178 0.42019199090811 no 1401 0.381211403168347 439 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1032 k061-1018 98.7 µM 0.301434936301664 0.420422969819571 no 1402 0.381541428554517 407 4005393
SGTC_1454 4239-0054 42.6 µM 0.296235736878546 0.421810568035675 no 1403 0.383525029432996 443 1340767
SGTC_1937 st074714 47.2 µM 0.290166275378567 0.423431655575686 no 1404 0.385844517579805 412 17250970
SGTC_1685 st024049 53.0905 µM 0.288692162481371 0.42382557198771 no 1405 0.386408480446235 439 1941139
SGTC_850 0388-0143 75.9 µM 0.285700896607213 0.424625139674785 no 1406 0.387553608958537 400 67273
SGTC_2059 5238311 157 µM 0.284989046523306 0.424815463578348 no 1407 0.387826266860747 407 703021
SGTC_2108 5365811 200 µM 0.284559254295439 0.424930383530325 no 1408 0.38799091574005 385 780283
SGTC_2736 butenafine 14.65 µM 0.284007419953533 0.425077945054289 no 1409 0.388202347192326 417 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_520 3584-0023 682 µM 0.283487846904268 0.425216889444339 no 1410 0.38840144824773 379 1340790
SGTC_2704 st078022 71.1 µM 0.282017613199785 0.425610110086927 no 1411 0.388965002429199 430 54697681
SGTC_1658 st012944 20 µM 0.281535680841981 0.425739021194419 no 1412 0.38914978247686 436 24207260
SGTC_2091 4-phenylthiadiazole 200 µM 0.278424990599131 0.426571283787285 no 1413 0.390343068953546 404 270010
SGTC_3050 9093513 49.47 µM 0.276530975808307 0.427078186307167 no 1414 0.391070135781541 425 25236664
SGTC_1600 coumarin 106 71.1 µM 0.275975508922909 0.42722687093965 no 1415 0.391283438532604 451 100336 A hepatotoxic, DNA x-linker.
SGTC_3162 9099653 49.47 µM 0.275778869067271 0.427279509003822 no 1416 0.391358957304919 409 25237511
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.275158465728483 0.427445591808055 no 1417 0.391597247627149 431 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1092 toremifene 6.32 µM 0.275055811256091 0.427473073788368 no 1418 0.391636680042765 444 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_661 1304-0007 33.6 µM 0.274521363135569 0.427616158407468 no 1419 0.391841994293542 428 3117130
SGTC_702 1488-0190 94 µM 0.272547236890559 0.428144761884958 no 1420 0.392600637802412 424 949357
SGTC_146 3448-8650 53.125 µM 0.270708202402464 0.42863730846548 no 1421 0.393307733847453 461 2891488 YIL048W NEO1
SGTC_2013 4024628 200 µM 0.270672723639862 0.428646811798863 no 1422 0.393321378655471 426 5230760
SGTC_3026 9090633 49.47 µM 0.270319630922374 0.428741393388739 no 1423 0.393457182027985 399 25236842
SGTC_3013 9080133 71.4286 µM 0.270303455295997 0.428745726389714 no 1424 0.393463403663808 402 17050193
SGTC_2862 9027634 71.43 µM 0.270227746227327 0.428766006860303 no 1425 0.393492524026253 390 5012562
SGTC_605 1315-0399 119 µM 0.269935169167413 0.428844382335945 no 1426 0.393605065020803 413 24020461
SGTC_1434 4073-0095 163 µM 0.269493370125206 0.42896273667841 no 1427 0.393775021719095 436 24133745
SGTC_698 k064-0052 127 µM 0.267417415777767 0.429518953184839 no 1428 0.394573895853599 452 5088751
SGTC_1777 st045864 34.765 µM 0.266549893354417 0.429751432523716 no 1429 0.39490786969191 443 4691462
SGTC_3123 9126162 49.47 µM 0.265552342363424 0.430018787127058 no 1430 0.395291996641506 393 25239884
SGTC_487 nimodipine 119 µM 0.263233716833434 0.430640327967824 no 1431 0.396185222318305 446 4497 L-type voltage-gated calcium channels inhibitor
SGTC_488 nitrendipine 139 µM 0.262957339699638 0.430714426317397 no 1432 0.396291730115454 419 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1064 honokiol 6.76 µM 0.261055552094305 0.431224372867537 no 1433 0.397024833844827 420 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_900 1112-0045 141 µM 0.260959165135126 0.431250221188842 no 1434 0.39706199893781 438 56211 YIL048W NEO1
SGTC_3020 9089140 49.47 µM 0.260654396884583 0.431331953556164 no 1435 0.397179518291018 401 17217859
SGTC_2843 9000894 45.46 µM 0.259779635094898 0.431566562395841 no 1436 0.397516880311426 396 2242070
SGTC_3082 9117008 49.47 µM 0.259357249289405 0.431679853819794 no 1437 0.397679805755717 409 41448529
SGTC_783 0848-0141 92.7 µM 0.258868667372218 0.431810907233509 no 1438 0.397868287064369 435 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_39 0986-0283 58.349 µM 0.255895737907094 0.432608503966514 no 1439 0.399015672870209 413 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2811 7967822 32.47 µM 0.255841222666336 0.4326231322421 no 1440 0.39903672091005 415 2232244
SGTC_1142 3253-1408 9.78 µM 0.254834347570126 0.432893327332532 no 1441 0.399425522664301 441 256655
SGTC_1307 1187-1599 12.2 µM 0.253501179542789 0.433251131439288 no 1442 0.399940474892591 426 1538471
SGTC_2251 lansoprazole 556 µM 0.251349193276753 0.433828810520824 no 1443 0.400772072424478 441 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3336 9143619 71.43 µM 0.249023602784599 0.434453250814524 no 1444 0.401671262012187 436 45595730
SGTC_2346 9031566 143.75 µM 0.248962083938273 0.434469771361353 no 1445 0.40169505536673 439 4771086
SGTC_491 tetrandrine 80.3 µM 0.248756428270374 0.434524999887062 no 1446 0.401774598486023 445 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3146 9095609 49.47 µM 0.247824745005605 0.434775218042258 no 1447 0.402135004148554 410 17173999
SGTC_3293 9120939 62.045 µM 0.246287549126737 0.435188113175581 no 1448 0.402729823758014 435 934087
SGTC_3136 9095672 49.47 µM 0.245558572594264 0.435383943054654 no 1449 0.403011980830401 445 17217380
SGTC_2763 lisinopril 49.32 µM 0.243764502434227 0.435865963611895 no 1450 0.403706607028738 460 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2507 purpurin 79.67 µM 0.241503405057283 0.436473598017736 no 1451 0.404582488861732 425 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1697 st025554 27.742 µM 0.241484604913146 0.436478650891683 no 1452 0.40458977348938 418 1269519
SGTC_6 0844-0013 19.835 µM 0.239456838165817 0.437023710042123 no 1453 0.405375680566859 446 1584900
SGTC_93 0109-0045 59.227 µM 0.239436579971977 0.437029156004081 no 1454 0.405383534020971 455 88733
SGTC_2675 theaflavin digallate 100 µM 0.237692503117272 0.43749805665533 no 1455 0.406059799350669 441 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1378 2093-0007 380 nM 0.236970297013334 0.437692249822949 no 1456 0.406339916781265 464 3618014
SGTC_2034 5197015 53.07 µM 0.235126937853285 0.438187976479531 no 1457 0.407055105660688 461 780676
SGTC_1781 st038725 66.3 µM 0.234803965528164 0.438274842048258 no 1458 0.407180444867909 402 4270275 YIL048W NEO1
SGTC_3023 9089636 49.47 µM 0.234311847979344 0.438407206073806 no 1459 0.40737144428187 429 17249241
SGTC_2565 isoliquiritigenin 100 µM 0.233620899872082 0.438593060843582 no 1460 0.407639650468778 410 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_355 1311-2252 105 µM 0.233023414852833 0.438753786351824 no 1461 0.407871611885193 430 5338538
SGTC_1451 4152-0210 104 µM 0.229572447772132 0.439682305096345 no 1462 0.409212009283131 456 659563
SGTC_684 1140-0066 328 µM 0.227399378522757 0.440267162707442 no 1463 0.410056601748826 422 6813534
SGTC_2067 5224629 34.075 µM 0.22669418100599 0.440456986913955 no 1464 0.41033077610934 420 2835000
SGTC_2868 9035608 32.47 µM 0.225325787404977 0.440825368435442 no 1465 0.410862919994243 447 6462614
SGTC_2352 9027995 87.8 µM 0.222690094368458 0.441535060241657 no 1466 0.411888355670665 442 2997347
SGTC_2356 9061756 188.97 µM 0.222545766358791 0.441573927723336 no 1467 0.411944524987759 435 20104043
SGTC_1500 4488-1866 171 µM 0.222344795773268 0.441628049967631 no 1468 0.412022741366336 472 2900003
SGTC_3005 9076496 71.4286 µM 0.219923075953032 0.442280314953608 no 1469 0.412965532118256 451 21368410
SGTC_1046 2001-0062 216 µM 0.219139960811335 0.442491272426509 no 1470 0.413270511488522 440 739778
SGTC_2984 9022109 38.96 µM 0.2171660217011 0.443023089199729 no 1471 0.414039481769174 459 6459207
SGTC_1944 st076371 56.9 µM 0.217061240424082 0.443051322148312 no 1472 0.414080309739897 468 24208455
SGTC_2398 5228213 48.84 µM 0.216149574316374 0.443296979579154 no 1473 0.414435579111722 455 80771 YMR134W ERG29
SGTC_2266 7929956 200 µM 0.213366284518702 0.444047098937475 no 1474 0.415520638024811 457 2967153
SGTC_780 0109-0199 192 µM 0.209421770425359 0.4451105205302 no 1475 0.417059499600512 465 610414
SGTC_2933 9026794 32.47 µM 0.208748497072007 0.445292071401361 no 1476 0.417322289426177 463 17586027
SGTC_565 1418-0001 44.5 µM 0.208506665434511 0.445357285079219 no 1477 0.417416689372246 430 2862145
SGTC_3189 9110682 49.47 µM 0.207589663923295 0.445604582277047 no 1478 0.417774687778332 448 17122418
SGTC_1305 1181-0477 144 µM 0.20625808089891 0.445963721578464 no 1479 0.418294660529669 433 6252086
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.205943692259239 0.446048521357541 no 1480 0.418417447708294 450 6708760
SGTC_3130 9127414 49.47 µM 0.205817450035902 0.446082573259188 no 1481 0.41846675492877 458 1494646
SGTC_2149 5554786 194.827 µM 0.20498941148076 0.446305933794149 no 1482 0.418790198889931 428 745063 YPR165W RHO1
SGTC_44 0929-0055 61.211 µM 0.202933677688425 0.446860534380195 no 1483 0.419593435462885 455 1379590
SGTC_771 0250-0039 27.3 µM 0.201963109989238 0.44712241255239 no 1484 0.419972781915403 483 3005115
SGTC_1154 4088-0362 150 µM 0.200600857211055 0.447490013895829 no 1485 0.420505343869753 458 6618304
SGTC_1889 st059080 5.18 µM 0.200348263676932 0.447558180751728 no 1486 0.420604109339961 438 176925 Isolated from Daphnopsis sellowiana.
SGTC_154 3389-1638 511.116 µM 0.199957909731018 0.447663527749722 no 1487 0.420756749722342 481 5238686
SGTC_2986 9022445 71.43 µM 0.198513496895143 0.448053371551157 no 1488 0.421321662942433 480 6459286
SGTC_2207 7258803 200 µM 0.197333901330079 0.448371779000621 no 1489 0.421783125737364 462 3666799
SGTC_2188 6126565 140.678 µM 0.195969263498477 0.448740176271722 no 1490 0.422317111842006 458 874518
SGTC_2602 kawain 100 µM 0.195890831178778 0.44876135118645 no 1491 0.422347806948929 468 5369129
SGTC_2412 st077135 33.4 µM 0.195835941076644 0.448776170333023 no 1492 0.422369288903855 458 13258915
SGTC_2213 7173844 200 µM 0.195457951414868 0.448878221348431 no 1493 0.42251722633809 456 892728
SGTC_1811 st050069 61.5 µM 0.195185857113375 0.448951684445713 no 1494 0.422623725258016 482 3877702
SGTC_380 3970-0968 6 µM 0.194904288589506 0.449027707343309 no 1495 0.422733938385677 473 2891601
SGTC_278 4092-0821 23.9 µM 0.193486976521888 0.449410406923735 no 1496 0.42328880228712 462 877900
SGTC_2754 granisetron 64.02 µM 0.192974425323192 0.449548816510832 no 1497 0.423489498625278 476 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1758 st042942 75.2445 µM 0.192878929486566 0.449574604934138 no 1498 0.423526893504132 461 669317
SGTC_2485 5633444 17.78 µM 0.192172515317245 0.449765377006275 no 1499 0.423803537115837 438 5724239
SGTC_730 1436-0052 41.2 µM 0.191096422784825 0.450056005597835 no 1500 0.424225025099764 433 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_351 caspofungin 25 nM 0.188908368128935 0.450647032804793 no 1501 0.425082317424185 440 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1570 verbenone 133 µM 0.187037047293928 0.451152592222678 no 1502 0.425815792961218 473 29025 A natural terpanoid with antifungal properties.
SGTC_3212 9128307 49.47 µM 0.184911395618236 0.451726958212715 no 1503 0.426649266358477 414 27243542
SGTC_838 0109-0203 71.4 µM 0.184163106296218 0.451929175347369 no 1504 0.42694275065777 442 759422
SGTC_3259 9138485 49.47 µM 0.183814106030046 0.452023493180868 no 1505 0.427079644841132 425 17646153
SGTC_752 1896-0090 130 µM 0.183042050295981 0.452232151987879 no 1506 0.427382512292228 459 772567
SGTC_3224 9130643 49.47 µM 0.182140526307646 0.452475818087109 no 1507 0.427736222620494 427 17644395
SGTC_1246 0422-0085 105 µM 0.181902879663559 0.4525400527857 no 1508 0.42782947227897 484 264295
SGTC_3076 9116187 49.47 µM 0.181184871024654 0.452734134466554 no 1509 0.428111234621198 472 27241210
SGTC_1195 1502-0147 41.1 µM 0.179261098106716 0.45325419639432 no 1510 0.42886634561776 472 817940
SGTC_870 0573-2213 57.6 µM 0.178943381180183 0.453340093936098 no 1511 0.428991079618373 463 3916321
SGTC_2688 kanamycin b 96.69 µM 0.178507397967741 0.453457969352123 no 1512 0.429162255883484 474 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2738 aclarubicin 5.55 µM 0.178093809751533 0.453569793693334 no 1513 0.429324651711724 473 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3150 9097574 49.47 µM 0.177681563067753 0.453681258979787 no 1514 0.429486532689912 471 17217476
SGTC_896 0964-0007 44.5 µM 0.175770903116582 0.454197920124767 no 1515 0.430236964827641 454 6756758
SGTC_2610 ononetin 44.17 µM 0.17509401359772 0.45438097631268 no 1516 0.430502881033062 448 259632
SGTC_127 0180-0333 59.125 µM 0.174626129971029 0.454507515173257 no 1517 0.430686707654699 462 771601
SGTC_612 0302-0167 22.4 µM 0.171878539459166 0.455250692211807 no 1518 0.431766509260629 458 235821
SGTC_687 k029-0044 34.9 µM 0.170808969178005 0.455540035488387 no 1519 0.432186988169065 486 5829338
SGTC_1018 4259-0013 28.1 µM 0.169995198712157 0.45576019485794 no 1520 0.432506956283406 449 6801262
SGTC_2381 9035592 200 µM 0.169843896495508 0.455801130014088 no 1521 0.432566452005413 458 4749657
SGTC_20 0481-0013 4.944 µM 0.169559566102337 0.455878057512594 no 1522 0.432678261786353 477 182045
SGTC_415 dibenzyl ketone 100 µM 0.168838422846159 0.456073175077746 no 1523 0.43296186754625 489 7593
SGTC_1928 4'-methoxychalcone 40.3 µM 0.167652113056022 0.456394174380967 no 1524 0.433428485541695 478 641818
SGTC_2089 5281248 129.67 µM 0.166699803824609 0.456651876917172 no 1525 0.433803129951087 442 2737878
SGTC_2351 9026858 72.31 µM 0.165282729388698 0.45703538237421 no 1526 0.434360725905511 463 1409300
SGTC_1632 st005650 90 µM 0.163191449805626 0.457601422211182 no 1527 0.435183849016035 453 2759605
SGTC_806 3966-4455 5.86 µM 0.16084107268201 0.458237693739889 no 1528 0.436109287517298 458 714982
SGTC_289 k017-0060 526 µM 0.160787058241739 0.458252317274862 no 1529 0.436130559318494 489 5512909
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.16046691835814 0.45833899112317 no 1530 0.436256639615837 463 6708784 An antioxidant flavonoid
SGTC_2597 laccaic acid a 100 µM 0.15711086338468 0.459247719261514 no 1531 0.437578738083506 466 5491415 A textile dye.
SGTC_835 0312-0010 67.2 µM 0.156194385810173 0.45949591360846 no 1532 0.437939900949387 464 1626196
SGTC_2171 5739187 198.077 µM 0.154634758229674 0.459918317791893 no 1533 0.438554633234693 481 2262761
SGTC_1242 0402-0103 60.1 µM 0.152089373265438 0.460607798084581 no 1534 0.439558222804931 459 432868
SGTC_1215 3852-0577 11.2 µM 0.151998936421552 0.460632297325351 no 1535 0.439593887258822 433 2884876
SGTC_2515 chrysin 20.77 µM 0.151540826661003 0.460756401045513 no 1536 0.439774553835926 454 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_627 1391-0720 175 µM 0.15065826065164 0.460995502383505 no 1537 0.440122650246467 500 997839
SGTC_1132 3456-3614 2.5 µM 0.150321591585635 0.46108671517286 no 1538 0.440255449458181 448 3125502
SGTC_1131 3454-3128 32.3 µM 0.149699424808609 0.461255282426205 no 1539 0.440500881001355 449 710982
SGTC_1645 Cervolide 78 µM 0.147918132937367 0.461737936557392 no 1540 0.441203688806182 466 23173 A fragrance.
SGTC_2792 7535235 81.82 µM 0.146428279837557 0.462141666519761 no 1541 0.441791651913528 458 1281891
SGTC_1678 st019265 80.2 µM 0.143923121250945 0.462820618218574 no 1542 0.442780588823988 478 5367020
SGTC_2303 7774051 200 µM 0.143589217418853 0.462911121542144 no 1543 0.442912427835405 485 2953184
SGTC_2154 5570129 200 µM 0.143110234271512 0.463040951396041 no 1544 0.443101561181139 504 673366
SGTC_59 0330-0160 1.33 µM 0.142252894779557 0.463273345720595 no 1545 0.443440126284381 485 4293482
SGTC_1483 3453-0561 55.9 µM 0.142155306307571 0.463299799289715 no 1546 0.443478666792027 481 4546991
SGTC_1992 st073643 23.3 µM 0.140652141900647 0.463707286532089 no 1547 0.444072377179657 492 3161292
SGTC_2608 thymoquinone 42.66 µM 0.136318482956497 0.46488229364268 no 1548 0.445784756494055 494 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1051 3253-3903 78 µM 0.136272162213568 0.464894854495209 no 1549 0.445803064951919 487 5509239
SGTC_3196 9111891 49.47 µM 0.136085671848547 0.464945425669447 no 1550 0.445876777179256 500 18891510
SGTC_2161 5662504 8.5105 µM 0.136053363789771 0.46495418680413 no 1551 0.445889547460668 458 2859334
SGTC_3093 9117344 49.47 µM 0.134872728000033 0.465274357218953 no 1552 0.446356251201584 459 24824913
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.131135296920726 0.46628803875618 no 1553 0.447834139671642 458 2724 A muscle relaxant with antifungal properties.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.129957132939167 0.466607630926783 no 1554 0.448300170976984 510 7104
SGTC_1614 st002383 48.6 µM 0.124953919736481 0.467965054412455 no 1555 0.450280015527338 489 1947235
SGTC_1753 st043925 64 µM 0.12476846156625 0.468015378390481 no 1556 0.45035342813344 493 670181
SGTC_2690 usnic acid 100 µM 0.124416858145095 0.468110787198389 no 1557 0.450492613092912 488 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2976 9009005 19.48 µM 0.12429718050923 0.46814326255812 no 1558 0.450539989809287 502 2993148
SGTC_2473 5854593 8.94 µM 0.123711470358711 0.468302202139072 no 1559 0.450771864699499 473 2872951
SGTC_1175 0741-0056 27.6 µM 0.123326068048547 0.468406788506338 no 1560 0.450924449539265 482 765927
SGTC_1289 0976-0073 69.1 µM 0.121850577377184 0.468807211514359 no 1561 0.451508678698038 491 3391136
SGTC_285 1486-1325 46 µM 0.121234392580067 0.468974442925007 no 1562 0.451752691838268 480 22310230
SGTC_1754 st042065 16.137 µM 0.119799777459916 0.469363815964903 no 1563 0.452320879117685 483 1126236 YIL048W NEO1
SGTC_3255 9139072 49.47 µM 0.119555285028935 0.469430177295461 no 1564 0.452417721473621 487 17646060
SGTC_2761 levamisole 97.89 µM 0.119502922915319 0.469444389786729 no 1565 0.452438462240347 492 26879 An alkaline phosphatase inhibitor.
SGTC_182 3448-4371 550.524 µM 0.11833339545702 0.469761841225421 no 1566 0.452901748766995 490 3491403
SGTC_2010 4012422 159 µM 0.116978963162967 0.470129506433936 no 1567 0.453438361988715 475 952393
SGTC_3355 9151058 44.0485 µM 0.116220548253303 0.470335391858624 no 1568 0.453738875976648 506 17015728
SGTC_3047 9092122 49.47 µM 0.115783464047933 0.470454049865851 no 1569 0.453912078071734 485 17173831
SGTC_1199 1638-0010 4.46 µM 0.115407504282337 0.470556116134893 no 1570 0.454061065575379 480 3111136
SGTC_1637 st007924 17.4 µM 0.115052149418444 0.470652590324521 no 1571 0.454201893592885 496 683336
SGTC_1857 st056007 79.3 µM 0.114832538559473 0.470712212656885 no 1572 0.454288928803011 479 619834
SGTC_903 1134-0042 114 µM 0.11414926908483 0.47089771824032 no 1573 0.454559733176571 466 701009
SGTC_683 panaxydol 45 µM 0.113838711777405 0.470982035694244 no 1574 0.454682825244759 486 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1726 st035556 14.5795 µM 0.111035431456741 0.471743195047316 no 1575 0.455794125099523 439 5919439
SGTC_737 1950-0117 57.9 µM 0.109816249947494 0.472074265096571 no 1576 0.456277551698237 478 5393513
SGTC_1139 k015-0024 46.9 µM 0.10889438889426 0.472324610280072 no 1577 0.456643128596704 502 2766652
SGTC_1910 st062352 60.4 µM 0.108413258466973 0.472455272806129 no 1578 0.456833942194264 496 2245730
SGTC_654 1124-0271 80.9 µM 0.107762482269289 0.472632011430311 no 1579 0.457092052169896 502 5403748
SGTC_2290 7904846 200 µM 0.107622692427378 0.472669976436896 no 1580 0.457147497793461 481 2962154
SGTC_2197 6588183 93.1375 µM 0.106007144212302 0.473108755134389 no 1581 0.457788341933452 483 884136
SGTC_2786 7743617 45.45 µM 0.103704891251766 0.473734097310662 no 1582 0.458701772465205 491 583674
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.100513996393722 0.474600920734201 no 1583 0.459968135797573 492 66535 A nucleotide analog.
SGTC_3143 9086658 49.47 µM 0.100426878554533 0.474624588459854 no 1584 0.46000271581512 475 25236626
SGTC_2649 anisomycin 9.56 µM 0.0994968257235845 0.474877265985213 no 1585 0.460371904050583 499 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_581 0958-0271 211 µM 0.0993720038280426 0.474911178472782 no 1586 0.460421455214504 485 4591145
SGTC_3180 9109287 49.47 µM 0.0989241805651161 0.475032847730229 no 1587 0.460599234878109 497 18891271
SGTC_1561 5-methoxyflavone 52.9 µM 0.0983151453515028 0.475198320452775 no 1588 0.460841026096675 504 94525
SGTC_196 k015-0023 18.111 µM 0.0983058397658415 0.47520084878088 no 1589 0.460844720591472 489 5211998
SGTC_35 0133-0054 64.071 µM 0.0981924489998887 0.475231657138038 no 1590 0.460889739157275 492 99677
SGTC_116 0155-0182 31.788 µM 0.0957010796092304 0.475908601140592 no 1591 0.461878991716626 485 771486
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0952047249376866 0.476043476832437 no 1592 0.462076108539627 515 5282309
SGTC_2308 7584454 197.62 µM 0.0936989990240806 0.476452648216754 no 1593 0.462674132721815 493 893577
SGTC_372 0155-0182 15.9 µM 0.0919235542193317 0.476935145850641 no 1594 0.463379388564771 497 771486
SGTC_2424 5537928 59.2 µM 0.0912569279612527 0.477116318006489 no 1595 0.463644220817891 515 5382802
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0912440531674053 0.47711981709649 no 1596 0.463649335777871 504 688801
SGTC_1002 4049-0206 172 µM 0.0884536524769763 0.477878228708086 no 1597 0.464758059926921 505 4662749
SGTC_2390 9097792 176.6 µM 0.0857326708216442 0.478617849883907 no 1598 0.465839465086478 474 4497149
SGTC_2858 9025781 8.96 µM 0.0856671350327641 0.478635664835399 no 1599 0.465865514248991 504 4894980 YPL153C RAD53
SGTC_2922 7999257 32.47 µM 0.0845763567203282 0.478932183302953 no 1600 0.466299098154128 520 2988377
SGTC_1106 tegaserod maleate 11.7 µM 0.0829430270945362 0.479376211314289 no 1601 0.46694842060693 495 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2886 9058944 51.95 µM 0.0827720010821598 0.479422706995523 no 1602 0.467016416305433 517 4949929
SGTC_3324 9138759 60.749 µM 0.0817116290080954 0.479710989379979 no 1603 0.467438015337334 499 45595710
SGTC_1896 st058441 89 µM 0.080164857089588 0.480131527835433 no 1604 0.468053070078064 476 688759
SGTC_579 4491-1009 110 µM 0.0799325132577629 0.480194699714764 no 1605 0.468145465356377 525 1271041
SGTC_3148 9097893 49.47 µM 0.0794226820255869 0.480333319282805 no 1606 0.468348213989219 514 17174100
SGTC_907 3448-6986 75.5 µM 0.0765299939919217 0.481119865586388 no 1607 0.469498726093021 492 590582
SGTC_209 4077-0173 175.592 µM 0.0760770812796731 0.481243023110766 no 1608 0.469678886888815 508 15993494
SGTC_1732 st034308 51.822 µM 0.0760288300634477 0.481256143846977 no 1609 0.469698080749557 485 830119
SGTC_140 0062-0056 502.533 µM 0.075102406485898 0.481508065964463 no 1610 0.470066616567837 500 3758964
SGTC_3275 9138069 49.47 µM 0.0750934797722852 0.481510493439408 no 1611 0.470070167783294 523 17617007
SGTC_1730 st033808 45.1 µM 0.0749461842626639 0.481550548162524 no 1612 0.470128765065497 526 1045166
SGTC_693 4161-2696 114 µM 0.0712816343022285 0.48254712445575 no 1613 0.471586805873617 523 805759
SGTC_1978 st071761 42 µM 0.0709858520974304 0.482627567422037 no 1614 0.471704507737185 485 5147680
SGTC_1630 st005209 31.3 µM 0.0701447870562668 0.482856313119191 no 1615 0.47203920977617 520 3367314
SGTC_656 4090-1979 187 µM 0.0694351101540197 0.483049329383689 no 1616 0.472321641243223 514 22330961
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0685882784098996 0.483279653896143 no 1617 0.472658674683855 502 15053
SGTC_2720 fluspirilene 36.88 µM 0.067432243148487 0.483594085747828 no 1618 0.473118800637973 502 3396 An atypical antipsychotic.
SGTC_2944 9067346 25.62 µM 0.0662288857661514 0.483921399653164 no 1619 0.473597799869142 509 6473075
SGTC_787 4152-0075 138 µM 0.0655137206664184 0.484115930122135 no 1620 0.473882491146568 516 9566539
SGTC_1714 st033236 13.627 µM 0.0651401804139676 0.484217537481861 no 1621 0.474031194503066 516 2916566
SGTC_2201 6605497 169.863 µM 0.0605248786912694 0.485473036551508 no 1622 0.475868800919052 518 670741
SGTC_53 0973-0023 39.979 µM 0.0603642892852006 0.48551672430171 no 1623 0.475932749895762 516 674768
SGTC_3111 9122088 49.47 µM 0.0602367728271808 0.485551414803342 no 1624 0.475983529197623 528 16876704
SGTC_939 1165-0479 45.3 µM 0.059638783699542 0.485714097555011 no 1625 0.476221664201468 514 1377347
SGTC_571 k831-0106 44.2 µM 0.0595588978590743 0.485735830653085 no 1626 0.476253477489878 520 4783639
SGTC_2189 6047310 154.431 µM 0.0588671472896878 0.485924024504169 no 1627 0.476528962659861 532 711535
SGTC_1394 3474-0001 65.7 µM 0.0566983336971798 0.486514080118004 no 1628 0.477392750699633 503 5017666 YIL048W NEO1
SGTC_1898 st060199 18.6 µM 0.0564623389147165 0.486578287553778 no 1629 0.477486748416548 523 688866
SGTC_1345 1488-0192 31.4 µM 0.0558162201216101 0.486754079787205 no 1630 0.477744106649599 517 658348
SGTC_2669 eugenol 100 µM 0.0551357825735577 0.486939212049268 no 1631 0.478015144559075 527 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3229 9132204 49.47 µM 0.053836542967745 0.48729271468127 no 1632 0.478532697323102 529 17682924
SGTC_418 lividomycin a 100 µM 0.0538091351544615 0.487300172024064 no 1633 0.478543615632561 500 72394 An antibiotic.
SGTC_672 1441-0018 53.7 µM 0.0531250287541945 0.487486310740372 no 1634 0.478816144772624 516 251141
SGTC_2 0422-0095 29 µM 0.0530679368105478 0.487501845028301 no 1635 0.478838889079414 495 6790840
SGTC_3069 9117009 49.47 µM 0.0524938030435201 0.487658063552953 no 1636 0.479067616491833 531 41904981
SGTC_1402 3909-7673 35.9 µM 0.0520826022964531 0.487769950097047 no 1637 0.479231437753014 512 5328014
SGTC_1502 4534-4282 27.7 µM 0.0516480073576976 0.487888203179721 no 1638 0.479404583009666 533 3278949
SGTC_1207 2099-0101 141 µM 0.0510888258518125 0.488040357774956 no 1639 0.479627370022265 520 5837381
SGTC_1670 st016595 4.04 µM 0.0491610829713522 0.48856491432649 no 1640 0.480395462517451 531 597879
SGTC_541 4513-1321 94 µM 0.0485354171040706 0.488735168054023 no 1641 0.480644769461673 526 747515
SGTC_825 1988-2224 89.6 µM 0.0481451107279145 0.488841377726997 no 1642 0.480800297352926 513 1180859
SGTC_1300 1094-0077 113 µM 0.0481156865160501 0.488849384638149 no 1643 0.48081202232658 514 5532636
SGTC_3295 9122362 53.5725 µM 0.0471867323913367 0.489102173758403 no 1644 0.481182200880824 518 4730473
SGTC_1060 3448-7350 82 µM 0.0449402409407798 0.489713512044351 no 1645 0.482077470799025 522 570178
SGTC_1955 wogonin 32.4 µM 0.0446344903811019 0.489796717921756 no 1646 0.482199325348239 531 5281703 A flavanone.
SGTC_378 3970-0959 8.33 µM 0.0438495647968032 0.490010326822462 no 1647 0.482512159029297 529 6615653
SGTC_343 4130-2827 29.8 µM 0.0419807816484519 0.490518907106009 no 1648 0.483257009315995 519 1118244
SGTC_738 1315-0003 72.4 µM 0.0399847703598808 0.491062128915602 no 1649 0.484052634037723 531 6251474
SGTC_1783 st039459 87.517 µM 0.0399279555736277 0.491077591515961 no 1650 0.484075281772213 539 729761
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0388655632218338 0.491366732570876 no 1651 0.484498786190666 536 676296 Flavone; oxidizing agent.
SGTC_1177 0983-0204 23.6 µM 0.0384482731180315 0.491480303633235 no 1652 0.484665136515201 525 766818
SGTC_713 1488-1073 324 µM 0.0381664164224276 0.491557015080205 no 1653 0.484777498594451 538 3312542
SGTC_2488 5268135 45.7 µM 0.0374202020443452 0.491760109803279 no 1654 0.485074982524094 528 1270356 YLR208W SEC13
SGTC_1623 st003709 20.3 µM 0.0365208656690546 0.492004882072593 no 1655 0.485433520704034 537 16192618
SGTC_2611 pyromycin 23.93 µM 0.0362925286225671 0.492067029020982 no 1656 0.485524553656163 528 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2300 7976697 71.57 µM 0.036094174202721 0.492121015694553 no 1657 0.485603633807783 536 2236109
SGTC_1908 st060353 56.5 µM 0.034504009323069 0.492553820420757 no 1658 0.48623762263802 521 4227716
SGTC_1977 st070720 65.3 µM 0.0339512657621985 0.492704266034722 no 1659 0.486458006280897 507 682188
SGTC_1994 st072947 40.9 µM 0.0331786743076097 0.492914551531589 no 1660 0.48676605209775 530 5286565 YDL195W SEC31
SGTC_2686 alizarin 95.37 µM 0.0325577804143708 0.493083549110794 no 1661 0.48701361915744 523 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3264 9137442 49.47 µM 0.0308104400397152 0.493559154318554 no 1662 0.487710357213077 492 17015726
SGTC_1297 1068-0111 14.1 µM 0.0281823669356509 0.494274501497387 no 1663 0.488758350392785 534 767057
SGTC_3307 9126885 69.2785 µM 0.0267840669480367 0.494655118785304 no 1664 0.489315980696673 521 24824909
SGTC_1014 4130-3005 69.3 µM 0.0263799763136597 0.49476511318657 no 1665 0.489477132589409 522 743608
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0248796068228464 0.495173520633309 no 1666 0.490075496798535 538 368090
SGTC_485 niflumic acid 177 µM 0.0244109654200851 0.495301088026347 no 1667 0.490262400896261 531 4488 A COX2 inhibitor.
SGTC_399 oxolinic acid 75 µM 0.0192703331630636 0.49670043196137 no 1668 0.492312725119573 521 4628 A DNA gyrase inhibitor.
SGTC_167 3672-0051 66.205 µM 0.0190510818762373 0.496760115909122 no 1669 0.492400177672925 540 3237971
SGTC_643 k048-0106 28.4 µM 0.0187366088719456 0.496845720962174 no 1670 0.492525611859283 537 6763920
SGTC_976 1348-1067 47.6 µM 0.0158820035200831 0.497622800634269 no 1671 0.493664263651756 540 5310671 YGL099W LSG1
SGTC_1325 1431-0015 227 µM 0.015600146114155 0.497699528296197 no 1672 0.493776694557644 525 1103340
SGTC_2043 5101342 149 µM 0.0153878759677315 0.497757312862316 no 1673 0.493861367929621 540 678451
SGTC_3274 9138298 49.47 µM 0.0150385778527057 0.497852399533629 no 1674 0.494000701590678 539 17015756
SGTC_3043 9092303 49.47 µM 0.0150089723639966 0.497860458808038 no 1675 0.494012511138991 540 25236084
SGTC_2434 5670830 169.91 µM 0.012322503984535 0.498591778650503 no 1676 0.495084156567443 537 1549830
SGTC_1581 himbacine 57.9 µM 0.0115209143400726 0.498809991222331 no 1677 0.49540392183512 533 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_519 k048-0011 62.8 µM 0.00759189939479671 0.499879570408206 no 1678 0.49697129943706 543 6836379
SGTC_526 4469-0568 170 µM 0.00670712358846338 0.499879570408206 no 1679 0.497324264882249 534 2901964
SGTC_2533 agelasine 13.65 µM 0.00664262267712879 0.499862011568833 no 1680 0.497349996449673 543 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_671 0560-0003 407 µM 0.00616072919386359 0.499730827537519 no 1681 0.497542240193683 543 3238678
SGTC_532 1548-0774 215 µM 0.00559806500674646 0.499577655642333 no 1682 0.497766706844993 542 5932993
SGTC_1103 duloxetine 36.1 µM 0.00530481039468676 0.499497824096899 no 1683 0.497883696769871 537 60835 A selective serotonin reuptake inhibitor.
SGTC_384 k007-0144 5.16 µM 0.00509003044580654 0.499439355411824 no 1684 0.497969380414995 545 6824886
SGTC_152 4469-0003 551.229 µM 0.00449619686552501 0.499277698541682 no 1685 0.498206283012902 544 697280
SGTC_80 0159-0065 512.242 µM 0.00439585973891203 0.499250384189881 no 1686 0.49824631133936 544 1548079
SGTC_3127 9126946 49.47 µM 0.00263993479367217 0.498772376848085 no 1687 0.498946819616615 547 27243249
SGTC_1683 st010134 710 nM 0.00198896134626018 0.498595165762885 no 1688 0.499206519748056 545 3818134
SGTC_1128 3448-9350 235 µM 0.0012607297658166 0.498396923431725 no 1689 0.499497041725492 547 619386
SGTC_2405 ticlatone 3.52 µM 0.00101145706347657 0.498329065433661 no 1690 0.49959648708137 544 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1105 epirubicin 18.1 µM -0.000597184461034224 0.497891155942493 no 1691 0.499761757883455 548 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_889 0919-1524 82.7 µM -0.000958865528484712 0.497792698307791 no 1692 0.499617468058086 549 3905452
SGTC_2289 7946404 165.07 µM -0.00295040707689351 0.497250558952163 no 1693 0.498822959580302 552 1246120 YPR165W RHO1
SGTC_2493 resveratrol 26.09 µM -0.00525513572137096 0.496623169907643 no 1694 0.497903513821086 550 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1848 st056003 16.4 µM -0.00527852258270933 0.496616803618917 no 1695 0.497894183942697 552 146492
SGTC_1696 st025591 34.7925 µM -0.00577363565392988 0.496482025893553 no 1696 0.497696665422914 549 2787147
SGTC_2497 7-hydroxyflavone 100 µM -0.00690257183313268 0.496174712870462 no 1697 0.497246294119221 558 5281894
SGTC_872 0588-0139 234 µM -0.00726571178777647 0.496075861310497 no 1698 0.497101425873563 552 2047100
SGTC_1748 st037455 53.6035 µM -0.0101478547392677 0.495291312434993 no 1699 0.495951661171537 552 580690
SGTC_3256 9138902 49.47 µM -0.0104209135087975 0.495216983933933 no 1700 0.495842732244456 552 17228773
SGTC_979 1426-2828 121 µM -0.0135251499517468 0.494372001429618 no 1701 0.49460441033823 556 747872
SGTC_593 1203-0218 61.7 µM -0.0139902123263174 0.494245412133627 no 1702 0.494418894853102 552 3666956
SGTC_530 4358-1714 28 µM -0.0161474371674213 0.493658226477507 no 1703 0.49355838452585 554 1564641
SGTC_1873 rapamycin 2 nM -0.0168614918347524 0.493463867384493 no 1704 0.493273556730394 554 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2063 5246145 200 µM -0.016863204168604 0.493463401304862 no 1705 0.493272873705135 561 711240
SGTC_2064 5220758 200 µM -0.0185351805158482 0.493008310927625 no 1706 0.492605956193999 557 788518
SGTC_2261 9010538 184.68 µM -0.019029114480155 0.492873870193632 no 1707 0.492408939807621 568 6457250
SGTC_1034 k072-0165 12.7 µM -0.0192698691851972 0.49280834099918 no 1708 0.492312910185597 561 5835461
SGTC_809 3998-0021 90 µM -0.0203221380171109 0.492521934239762 no 1709 0.491893197924405 557 715485
SGTC_2262 9014885 67.46 µM -0.0209468435208434 0.492351903574182 no 1710 0.491644029541597 561 6457424
SGTC_1841 st054148 70 µM -0.021276355106073 0.492262218554063 no 1711 0.491512602730665 567 675442
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0216118124581979 0.492170915642978 no 1712 0.491378805377067 559 3256 An antibiotic and ribosome inhibitor.
SGTC_1042 0350-0096 82 µM -0.022601174470411 0.491901639015552 no 1713 0.490984203488033 557 3122515
SGTC_2085 5307070 144.047 µM -0.0234605583862478 0.491667741775981 no 1714 0.490641449833344 564 2840351
SGTC_2400 5203494 178.7 µM -0.0235160783081959 0.49165263109923 no 1715 0.490619306698115 559 6777674
SGTC_3299 9121982 43.1275 µM -0.0235450748068786 0.491644739221165 no 1716 0.490607741970876 571 17594604 YPL160W CDC60
SGTC_3184 9108758 49.47 µM -0.0238899266566445 0.491550882321991 no 1717 0.49047020467738 560 902885
SGTC_306 1672-3436 11.6 µM -0.0239390663776768 0.491537508205669 no 1718 0.490450606369983 560 6797378
SGTC_1228 0124-0032 52.5 µM -0.0258378648230964 0.491020728997074 no 1719 0.489693330080189 572 X1228
SGTC_2114 5491910 81.25 µM -0.0270641371672946 0.490686993235227 no 1720 0.489204289335372 561 2849228
SGTC_493 zm226600 134 µM -0.0274207858778834 0.490589930831704 no 1721 0.489062059873934 564 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1230 0170-0365 3.77 µM -0.0280508933731692 0.490418447635066 no 1722 0.48881078002749 558 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1254 0550-0035 264 µM -0.0290369828590715 0.49015008782147 no 1723 0.488417547482231 562 15121435
SGTC_2528 xanthyletin 44.79 µM -0.0321141217909527 0.489312687534509 no 1724 0.487190520829347 560 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_587 k089-0003 57 µM -0.0322888208226839 0.489265147016805 no 1725 0.487120862124463 561 9659696
SGTC_2569 tetrandrine 100 µM -0.0334218188622584 0.488956830131172 no 1726 0.486669105222301 572 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2561 acetosyringone 100 µM -0.0355783540349986 0.488370001776445 no 1727 0.48580928418509 560 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1919 st067113 52.3 µM -0.0405587212506893 0.487014861048392 no 1728 0.483823846364355 573 1268243
SGTC_3326 9140064 16.379 µM -0.0461984293059625 0.485480497789771 no 1729 0.48157604718604 571 1868434
SGTC_1359 1582-0056 520 nM -0.0464443499832839 0.485413596277271 no 1730 0.481478044227957 584 3661189
SGTC_923 1900-2434 73.3 µM -0.0466321876983322 0.485362496225865 no 1731 0.481403188926785 568 5910570
SGTC_3325 9138760 55.175 µM -0.0476149278138037 0.485095151988092 no 1732 0.481011567424471 584 43844959
SGTC_3198 9112019 49.47 µM -0.0489886784363032 0.484721448659319 no 1733 0.480464159203281 570 45595555
SGTC_2906 7926292 26.41 µM -0.0491870515923019 0.484667486029612 no 1734 0.480385115054699 578 2966319
SGTC_2934 9036370 36.88 µM -0.0513248406612881 0.484085970128039 no 1735 0.479533337100766 577 6462800
SGTC_2011 4012611 177 µM -0.0516235245040606 0.484004725581539 no 1736 0.479414337242831 571 2049887
SGTC_2121 5257820 149.641 µM -0.0525024546885611 0.483765652958239 no 1737 0.479064169737825 569 791256
SGTC_1640 st009078 66.4 µM -0.0551354643916395 0.483049498767449 no 1738 0.478015271302503 576 690618
SGTC_2902 5787006 60.46 µM -0.0555908350770256 0.482925647651376 no 1739 0.477833882882391 576 591003
SGTC_992 3909-8734 162 µM -0.0570289061515746 0.482534533858338 no 1740 0.477261084413185 586 4288319
SGTC_1185 1319-0113 81.3 µM -0.0571477716873578 0.482502206612976 no 1741 0.477213741135925 570 4672763
SGTC_112 phenothiazine 287.218 µM -0.0582895025783984 0.482191701854465 no 1742 0.476759014513976 578 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_723 4182-0001 115 µM -0.0583499328645169 0.482175267553022 no 1743 0.476734947281261 581 744821 YLR208W SEC13
SGTC_2031 5180455 200 µM -0.0607022443866671 0.481535569146328 no 1744 0.475798172108662 567 29949
SGTC_1744 st037937 38.9 µM -0.065624090283908 0.480197255485243 no 1745 0.4738385545891 588 1016152
SGTC_314 1671-0008 2.74 µM -0.066226112570939 0.480033572843035 no 1746 0.473598903790363 586 3913060
SGTC_967 1306-0166 352 µM -0.066383276531662 0.47999084239941 no 1747 0.473536342113139 572 4437607
SGTC_2453 5731132 22.18 µM -0.0667133045970347 0.479901113635475 no 1748 0.473404971186618 592 1362040
SGTC_1644 st010134 20.9 µM -0.0673402877267969 0.479730650877719 no 1749 0.473155402346663 576 3818134
SGTC_1605 st000082 49.1 µM -0.0683515318406773 0.479455723935542 no 1750 0.472752901766456 605 1114022
SGTC_1624 st003710 6.25 µM -0.0703482840882772 0.478912895719158 no 1751 0.471958226262642 591 24207033
SGTC_323 4013-0906 34.3 µM -0.0711706692090834 0.478689337059147 no 1752 0.471630962392076 572 2910086
SGTC_3244 9134489 49.47 µM -0.0713023052761557 0.478653553493029 no 1753 0.471578580278203 588 16584271
SGTC_2313 7726885 200 µM -0.0716261774917982 0.478565513743726 no 1754 0.471449703474836 579 726423
SGTC_2869 9037858 32.47 µM -0.072581091424906 0.478305940979319 no 1755 0.471069736942529 570 27187042
SGTC_1343 1487-0095 224 µM -0.0731692042726416 0.478146079753446 no 1756 0.470835736055452 584 4560101 YGL055W OLE1
SGTC_2936 9038235 15.59 µM -0.0738716210886598 0.477955152956502 no 1757 0.470556268612218 572 4749415
SGTC_1523 st012844 44.7 µM -0.0767233723685804 0.477180059164341 no 1758 0.469421805439914 598 4274103
SGTC_2116 5511452 16.8835 µM -0.0773835219801864 0.477000645522247 no 1759 0.469159224513541 613 870744
SGTC_2383 9036125 200 µM -0.0791588104389599 0.476518185744323 no 1760 0.468453153125037 584 79580
SGTC_3291 9121177 71.43 µM -0.0808188795326805 0.476067069587962 no 1761 0.467792996743781 589 17015612
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0817540326895426 0.4758129594795 no 1762 0.467421155125379 574 5355888
SGTC_296 1222-0039 74.9 µM -0.0825116317283093 0.475607103538067 no 1763 0.467119934546952 600 5984176
SGTC_3346 9158254 43.5805 µM -0.0828275592223009 0.475521261168445 no 1764 0.466994327661938 573 17639500
SGTC_1271 0832-2808 169 µM -0.0829098057123661 0.475498913715638 no 1765 0.46696162852867 606 3663794
SGTC_3074 9116018 49.47 µM -0.0836120561838566 0.475308106174407 no 1766 0.466682440527988 584 17027303
SGTC_1412 3909-8563 178 µM -0.0845433745947703 0.475055067630092 no 1767 0.46631220916034 603 23767530
SGTC_1316 1272-0050 65.9 µM -0.0848088300415649 0.474982945413728 no 1768 0.466206686738392 582 7340392
SGTC_326 k292-0812 17.5 µM -0.0852922763460792 0.474851598854754 no 1769 0.466014515870781 616 3579357
SGTC_3288 9119690 36.221 µM -0.086057439572443 0.474643718781029 no 1770 0.465710378179473 601 17595618 YKL019W RAM2
SGTC_2125 5246583 200 µM -0.0893599232124822 0.473746577655038 no 1771 0.464397936325125 590 835267
SGTC_3128 9127691 49.47 µM -0.0910824385183262 0.473278697728038 no 1772 0.463713543333278 593 41316314
SGTC_1248 0469-0687 58.6 µM -0.0912274578775559 0.473239308374236 no 1773 0.463655928843249 603 4017482
SGTC_2698 st077697 67.5 µM -0.0922537693736786 0.472960554840238 no 1774 0.463248209181251 585 3154499
SGTC_3158 9100007 49.47 µM -0.0934737893555945 0.472629205934752 no 1775 0.46276358578789 596 19297233
SGTC_2652 actinonin 100 µM -0.0936106336824917 0.472592041148527 no 1776 0.46270923112666 586 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_350 k064-0020 19.8 µM -0.0943637792630733 0.472387502826983 no 1777 0.462410093669978 605 2790705
SGTC_2021 4019055 173 µM -0.0944577086622471 0.472361994109462 no 1778 0.462372787892769 606 44827708 YER133W GLC7
SGTC_75 0159-0059 199.013 µM -0.0963825160251122 0.471839292921028 no 1779 0.461608388830672 577 5377270
SGTC_2537 larixol 68.93 µM -0.0964948476328593 0.471808789609492 no 1780 0.461563782912848 589 6708759
SGTC_1258 0671-0043 57.1 µM -0.103544609453987 0.469894786087669 no 1781 0.45876537325723 624 4298767
SGTC_1054 3429-0080 167 µM -0.104600510344681 0.469608168815255 no 1782 0.458346404866063 630 1162877
SGTC_60 0986-0278 202 µM -0.105005909582194 0.469498130064644 no 1783 0.458185559739243 592 3110598
SGTC_2211 7117706 200 µM -0.107363234387059 0.468858320632208 no 1784 0.457250410291197 579 822771
SGTC_2831 7999036 19.48 µM -0.108283457262121 0.468608581587018 no 1785 0.456885422322277 610 2988270
SGTC_1573 oleylamine 1.06 µM -0.108298212833536 0.468604577176712 no 1786 0.456879570115899 612 5356789 An amine of the fatty acid oleic acid.
SGTC_2407 paclitaxel 400 µM -0.108393406111486 0.468578743421729 no 1787 0.456841815739928 691 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_65 0798-0905 34.986 µM -0.109147585771261 0.468374077220862 no 1788 0.456542716163891 677 3602145
SGTC_125 0133-0007 11.75 µM -0.113414885567537 0.46721619382132 no 1789 0.454850819439474 598 26541
SGTC_482 fipronil 114 µM -0.114762338810466 0.466850634819489 no 1790 0.454316750522055 584 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1278 0874-0585 172 µM -0.115137946796131 0.466748738754468 no 1791 0.454167891350519 593 766306
SGTC_1820 st053765 18.6 µM -0.116308074252005 0.466431317055328 no 1792 0.453704193358321 605 3690829
SGTC_812 4251-0442 148 µM -0.116952995647942 0.466256377667339 no 1793 0.453448650905559 625 5723007
SGTC_1205 4161-2785 76 µM -0.118653072880536 0.465795251295194 no 1794 0.452775108113581 656 3498106
SGTC_218 alverine citrate 93.75 µM -0.118857898423106 0.465739697812705 no 1795 0.452693968715671 597 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1403 3909-7815 62.9 µM -0.120885556153113 0.46518978575498 no 1796 0.451890841392513 607 6615483
SGTC_2012 4023501 200 µM -0.12222447433447 0.464826700067892 no 1797 0.451360622025004 610 3477460
SGTC_994 3910-0338 138 µM -0.122856335650045 0.464655363081151 no 1798 0.451110431354879 604 3479481
SGTC_2438 5259590 200 µM -0.123147272569847 0.464576474149534 no 1799 0.450995239019297 606 1201127
SGTC_760 0568-0725 82.9 µM -0.124695680677029 0.464156639416941 no 1800 0.450382238516119 594 3916171
SGTC_1191 1487-1166 10.6 µM -0.124763313868196 0.464138302287752 no 1801 0.450355465845906 598 3955771
SGTC_1351 1496-0003 46.5 µM -0.125890543245097 0.463832692130431 no 1802 0.449909284257856 600 3891978
SGTC_421 streptovitacin 30 mM -0.127414509494997 0.463419554136209 no 1803 0.449306166460009 624 91467 include heat shock
SGTC_3068 9116768 49.47 µM -0.127677174221706 0.463348351297223 no 1804 0.449202227281233 606 41904888
SGTC_25 0118-0223 35.662 µM -0.130558151832887 0.462567456901228 no 1805 0.448062424639481 607 5333628
SGTC_1725 st036284 20.55 µM -0.131329483430255 0.462358410376957 no 1806 0.447757334683971 621 707914
SGTC_2974 9094440 9.66 µM -0.132315343770554 0.462091237351518 no 1807 0.447367435752871 612 25236134
SGTC_2468 5987765 72.9 µM -0.132911649110331 0.461929643950713 no 1808 0.447131626993834 588 26772094
SGTC_1882 5615643 20 µM -0.133980867811922 0.461639911022285 no 1809 0.446708851646847 601 2253075
SGTC_2061 5245884 80.95 µM -0.135163740106206 0.461319404387619 no 1810 0.446241207580542 627 573863
SGTC_1491 4138-0063 26.5 µM -0.135204749601271 0.46130829305822 no 1811 0.44622499596971 612 23883227
SGTC_3318 9139014 38.6185 µM -0.136459135720353 0.460968437683902 no 1812 0.445729163638396 603 16643984
SGTC_2667 digitoxin 100 µM -0.137511961156414 0.460683213868089 no 1813 0.445313069461292 606 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3054 9094397 49.47 µM -0.13840333820226 0.460441744282755 no 1814 0.444960829452196 636 2598354
SGTC_51 1013-0126 23.419 µM -0.139163856036248 0.460235735332417 no 1815 0.444660334618486 600 1627850
SGTC_1165 k072-0275 30.3 µM -0.13949461438365 0.46014614289093 no 1816 0.444529655716432 610 6153523 YGL055W OLE1
SGTC_746 1095-0025 46.6 µM -0.140762507613959 0.459802727711629 no 1817 0.444028781340725 612 6749286
SGTC_1220 1838-0075 193 µM -0.140776405400592 0.45979896359277 no 1818 0.444023291588956 624 5529645
SGTC_1734 st037168 69.4 µM -0.141589026068987 0.459578877211998 no 1819 0.443702317763766 633 708907
SGTC_3317 9138495 8.753 µM -0.141920571844891 0.459489086458687 no 1820 0.443571372403619 604 17020139
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.143306907873713 0.459113654989958 no 1821 0.443023900225407 615 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1655 st012546 55.1 µM -0.147430372654006 0.457997202809326 no 1822 0.441396166770707 629 720985 YLR208W SEC13
SGTC_1861 st057647 17.4 µM -0.150361660955929 0.457203740336137 no 1823 0.440239643730689 601 688668
SGTC_1822 st052468 42 µM -0.153298817896868 0.456408860376402 no 1824 0.439081316419441 616 2873678
SGTC_2252 omeprazole 400 µM -0.157300821376675 0.455326083343585 no 1825 0.437503886476536 641 4594 A proton pump inhibitor.
SGTC_2856 9022925 19.48 µM -0.157364823203561 0.455308769763734 no 1826 0.437478667511653 621 4944862
SGTC_2684 capsaicin 100 µM -0.158727692156438 0.454940110794311 no 1827 0.436941709789059 619 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1702 st027038 51 µM -0.160131653001124 0.454560376960664 no 1828 0.436388683703003 618 5521182
SGTC_2701 st077767 14.721 µM -0.160529965278026 0.45445265169641 no 1829 0.436231809412193 637 5721188
SGTC_3183 9108214 49.47 µM -0.161324883825161 0.454237672586896 no 1830 0.435918762744924 640 4974831
SGTC_247 mechlorethamine 29.705 µM -0.162206942293752 0.453999142903252 no 1831 0.435571446520463 616 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3095 9117207 49.47 µM -0.162565427322499 0.453902204723495 no 1832 0.435430304908939 603 17015229
SGTC_2337 9009472 200 µM -0.162576303789423 0.453899263653591 no 1833 0.435426022788652 621 5742383
SGTC_1987 st072290 61.9 µM -0.162751664969074 0.453851845158714 no 1834 0.435356983246825 648 54697379
SGTC_3253 9135987 49.47 µM -0.163685456021031 0.453599354722622 no 1835 0.43498938376448 630 4182430
SGTC_1322 1348-1070 12 µM -0.163705773965016 0.453593861103679 no 1836 0.434981385954311 618 6758089
SGTC_160 3453-0671 289.699 µM -0.167286898593992 0.452625726903059 no 1837 0.433572156143518 655 5322268
SGTC_45 0kpi-0036 14.9 µM -0.167748489506713 0.452500959108489 no 1838 0.433390573770282 612 2795021
SGTC_1235 benzylparaben 21.5 µM -0.16960669752306 0.451998733972042 no 1839 0.432659727503717 650 7180
SGTC_647 0140-0236 81 µM -0.169929589539377 0.451911472495908 no 1840 0.432532755222587 629 990837
SGTC_390 dec-rvkr-cmk 16.7 µM -0.174339382170602 0.450719961567188 no 1841 0.43079937531575 636 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1718 roemerine 11.9335 µM -0.174818396531821 0.450590560061193 no 1842 0.430611166297987 640 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3270 9137563 49.47 µM -0.175599426064523 0.45037958308839 no 1843 0.430304326640159 613 17015724
SGTC_1676 st018489 23.4 µM -0.175976694352555 0.450277677848679 no 1844 0.430156125958315 611 3696235
SGTC_2525 harmine 47.85 µM -0.177283934791585 0.449924600021778 no 1845 0.429642684548573 619 5280953 A monoamine oxidase inhibitor
SGTC_1525 8-methoxypsoralen 92.5 µM -0.178749050906186 0.449528928036403 no 1846 0.429067376161857 683 4114 Related to psoralen; DNA damaging agent.
SGTC_1722 st034304 3.6505 µM -0.179269833726328 0.449388296525835 no 1847 0.428862916159563 640 4036148 YLR033W RSC58
SGTC_1803 st050068 52.4 µM -0.179903005060726 0.449217324332806 no 1848 0.428614357998775 632 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1993 st073995 70.8 µM -0.182750876517143 0.448448444402251 no 1849 0.427496747114268 627 3098394
SGTC_1127 asiatic acid 681.4 nM -0.183007961809558 0.448379044952622 no 1850 0.427395885751293 626 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_980 1473-0395 201 µM -0.184741771658259 0.447911049230991 no 1851 0.426715790507135 610 768876
SGTC_3065 9113888 49.47 µM -0.185482855972142 0.447711035365859 no 1852 0.42642516295348 662 16648368
SGTC_3029 9088683 49.47 µM -0.186868583905998 0.447337072066221 no 1853 0.425881835841473 633 25236615
SGTC_739 1486-1183 203 µM -0.188576641468903 0.446876186837481 no 1854 0.425212320864292 648 4346692
SGTC_2133 5320837 200 µM -0.189024241719994 0.44675542268465 no 1855 0.425036908566068 657 2841355
SGTC_1040 k898-0338 155 µM -0.190434559462196 0.446374946239692 no 1856 0.42448430930724 626 20969351
SGTC_1973 st070275 50.2 µM -0.192057161984129 0.445937260557711 no 1857 0.423848714982464 619 17118334
SGTC_740 k014-0057 261 µM -0.192139675255317 0.44591500493543 no 1858 0.423816398748335 653 4012779
SGTC_1462 k081-0014 26.5 µM -0.193949114401913 0.445427002840542 no 1859 0.42310786302513 651 3270634
SGTC_250 brefeldin a 552.239 µM -0.194064840463447 0.44539579455992 no 1860 0.423062555733966 624 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1762 st045503 25.4615 µM -0.195016167795522 0.445139259395146 no 1861 0.422690145275962 651 4645554
SGTC_2546 rhodinyl acetate 100 µM -0.195474541573913 0.44501566240252 no 1862 0.422510733059161 648 6708682
SGTC_452 diindolylmethane 8 µM -0.195835551780531 0.444918322516278 no 1863 0.422369441260773 660 3071 Inhibits expression of several cancer promoting factors.
SGTC_1093 fluphenazine 7.97 µM -0.19740121475867 0.444496208264404 no 1864 0.421756789542065 662 6602611 An atypical antipsychotic.
SGTC_1788 fluconazole 20 µM -0.197747099854965 0.44440296357089 no 1865 0.421621468463215 626 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1540 guanosine 70.6 µM -0.198055974232622 0.444319698933325 no 1866 0.421500634958588 623 6802 Guanosine is a purine nucleoside
SGTC_3348 9149464 3.537 µM -0.199119173892563 0.444033106289606 no 1867 0.421084761471338 632 1951442
SGTC_414 piperonyl butoxide 100 µM -0.199642606537205 0.443892022228474 no 1868 0.420880051655333 646 5794 A potent inhibitor of cytochrome P450.
SGTC_3015 9080845 49.47 µM -0.200768781546074 0.443588501393063 no 1869 0.42043968729407 659 5296973
SGTC_1030 k029-0042 36.7 µM -0.201072061011008 0.443506768736122 no 1870 0.42032111395524 630 6080581
SGTC_3110 9122132 49.47 µM -0.20205871266836 0.443240886529309 no 1871 0.41993541229423 611 918317
SGTC_1752 st044819 83.042 µM -0.203610709385812 0.442822707283418 no 1872 0.419328861790161 634 441209 YML126C ERG13
SGTC_914 3820-6779 408 µM -0.203708412858977 0.442796383603314 no 1873 0.419290683769842 629 2893481
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.203870132993091 0.442752812840488 no 1874 0.419227492654834 634 4330530
SGTC_2918 7977171 22.06 µM -0.20626871424928 0.442106666800323 no 1875 0.418290507722651 631 2236483
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.207498155273767 0.441775531251615 no 1876 0.417810416601241 657 688667
SGTC_120 rhodamine 6G 52.259 µM -0.209934538169102 0.44111944046385 no 1877 0.416859382640929 640 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3311 9131146 2.8755 µM -0.212040407792216 0.440552483324185 no 1878 0.41603775506907 644 4900406 YPR165W RHO1
SGTC_451 chloral hydrate 100 µM -0.213230861695481 0.440232034723782 no 1879 0.415573448799351 672 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1988 st071872 53.4 µM -0.214272380746988 0.439951708781211 no 1880 0.415167327411901 632 16414116
SGTC_2265 7929201 200 µM -0.215047377199358 0.439743137199218 no 1881 0.414865190440313 681 1265108
SGTC_1818 st052136 56.3 µM -0.215068018483884 0.439737582324275 no 1882 0.414857144000507 634 674169
SGTC_1086 cerivastatin 2.18 µM -0.21539921676794 0.439648453590866 no 1883 0.414728040301608 628 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3192 9110362 49.47 µM -0.217562623092411 0.439066335005406 no 1884 0.413884954657597 632 16649480
SGTC_550 4123-0385 25.7 µM -0.217993399690969 0.438950439476396 no 1885 0.413717127025847 674 5731123
SGTC_3176 9106582 49.47 µM -0.218508811279271 0.438811780746946 no 1886 0.413516346888407 625 17018027
SGTC_181 1447-1644 8.07 µM -0.220902549817031 0.438167903334415 no 1887 0.412584155998648 664 534600
SGTC_109 0132-0036 33.701 µM -0.223789315431859 0.437391627341884 no 1888 0.411460622092941 624 67274 A color developer.
SGTC_767 0929-0023 86 µM -0.22606979551609 0.436778556919623 no 1889 0.410573568082455 628 1204563
SGTC_1920 st075728 45.7 µM -0.227535442219149 0.436384621400092 no 1890 0.41000370648064 627 3400306
SGTC_585 0kpi-0023 191 µM -0.22771165238123 0.436337263993902 no 1891 0.409935206558315 664 64601
SGTC_631 k072-0230 41.5 µM -0.228848789751514 0.436031674331209 no 1892 0.40949322206843 668 5773147
SGTC_3351 9150312 21.596 µM -0.229023810267355 0.435984643417281 no 1893 0.409425204995152 640 4904905
SGTC_128 0906-2981 13.371 µM -0.229092232783292 0.435966257399079 no 1894 0.409398615143429 668 6740226
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.230135227553883 0.435686008320587 no 1895 0.408993345904995 667 23847180
SGTC_2107 5363541 170.161 µM -0.231246997741133 0.435387315086978 no 1896 0.408561460187411 651 244052
SGTC_224 benfluorex 43.875 µM -0.232251238030816 0.435117543004575 no 1897 0.408171441675599 669 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_509 pifithrin 175 µM -0.236543143207445 0.433964937468579 no 1898 0.406505616750187 647 4817 A p53 inhibitor.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.239011821053456 0.433302219362577 no 1899 0.405548208242647 663 260807
SGTC_1897 st060201 15 µM -0.239924350028004 0.433057297756111 no 1900 0.405194451754453 644 611878
SGTC_817 1391-0715 46 µM -0.240050619226303 0.433023409288129 no 1901 0.405145507568235 668 1353946
SGTC_3090 9117696 49.47 µM -0.240380397111698 0.432934904933425 no 1902 0.405017686795382 682 7923821
SGTC_3125 9127534 49.47 µM -0.243137556157601 0.432195082629396 no 1903 0.403949419179754 629 1639235
SGTC_147 4466-0538 29.23 µM -0.243425932349608 0.432117716978523 no 1904 0.403837728383016 671 6742687 YHR072W ERG7
SGTC_890 0929-0006 47.2 µM -0.244499434944326 0.431829740285972 no 1905 0.403422019772012 662 1378169
SGTC_1331 1472-0049 76.2 µM -0.245211805216599 0.431638660559838 no 1906 0.403146218071485 648 24051409
SGTC_3099 9120367 49.47 µM -0.245858895463564 0.431465104816034 no 1907 0.402895731974907 665 24824940
SGTC_534 k292-0788 63.4 µM -0.246110350417634 0.431397665779211 no 1908 0.402798405493814 680 4146317
SGTC_3031 9088762 49.47 µM -0.246204099673234 0.431372523181144 no 1909 0.402762121071882 657 205253
SGTC_1202 1988-0068 29.6 µM -0.246772810828438 0.431220006589532 no 1910 0.402542026826165 652 2850480
SGTC_700 3453-2283 142 µM -0.247594802809852 0.430999583437511 no 1911 0.402223966152196 645 565664
SGTC_441 propafenone 146 µM -0.247926540337746 0.430910631679958 no 1912 0.402095622318291 638 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_359 0081-0058 15.9 µM -0.248134341569708 0.430854913857566 no 1913 0.402015232790003 665 3494159
SGTC_136 0097-0015 404.482 µM -0.249122168431267 0.430590066310011 no 1914 0.401633141000992 652 4861337
SGTC_762 1165-0429 115 µM -0.250253406845806 0.430286806855063 no 1915 0.401195693073945 648 5967793
SGTC_1009 4106-0057 9.87 µM -0.253185671645976 0.429500924765679 no 1916 0.400062369125878 653 2928005
SGTC_287 k060-0039 29.6 µM -0.253456164431798 0.429428443482822 no 1917 0.399957865564779 660 5861974
SGTC_1498 4478-3555 97.6 µM -0.254258918083186 0.429213351523671 no 1918 0.399647767837338 660 3437919
SGTC_662 k832-1615 104 µM -0.254350397845474 0.429188841524371 no 1919 0.399612433903258 665 5878478
SGTC_228 caffeine 993.056 µM -0.255173419105604 0.428968343286359 no 1920 0.399294580062068 662 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_833 3852-0053 558 µM -0.256554459040668 0.428598394330374 no 1921 0.39876136742665 679 3123681
SGTC_2710 st078562 53.7235 µM -0.256795288897066 0.428533887944022 no 1922 0.398668403534326 685 17250908
SGTC_793 0488-0545 106 µM -0.2593484115707 0.427850150617168 no 1923 0.397683214889716 652 292548
SGTC_1610 st001799 48.1 µM -0.259438811847482 0.42782594498922 no 1924 0.397648343515391 644 621897
SGTC_447 ml7 120 µM -0.260879704264219 0.427440167569023 no 1925 0.397092638335942 667 4216 Selective myosin light chain kinase inhibitor.
SGTC_650 1328-0195 38 µM -0.261806154971916 0.427192160847752 no 1926 0.396735446779104 678 2780821
SGTC_153 4077-0274 519.67 µM -0.262043690922985 0.427128578163844 no 1927 0.396643879122369 630 3121976
SGTC_621 3584-0052 32.1 µM -0.262059531305382 0.427124338140246 no 1928 0.396637773021153 694 2273927
SGTC_3310 9130229 44.1445 µM -0.262294332750649 0.427061489403376 no 1929 0.396547265465413 688 7761258
SGTC_106 0092-0003 11.579 µM -0.262842515533035 0.426914765848955 no 1930 0.396335982322746 667 1072148
SGTC_248 streptozotocin 5.23457 mM -0.263754093263901 0.426670800420592 no 1931 0.39598470524601 677 5300 DNA alkylating agent.
SGTC_1299 1079-1439 3.74 µM -0.264424142890876 0.426491493009134 no 1932 0.395726555017114 677 323161
SGTC_2618 avocadyne 43.43 µM -0.264872589797601 0.426371495674509 no 1933 0.395553807278002 653 3015189
SGTC_2524 avocatin b 10.57 µM -0.266847730448718 0.425843060385671 no 1934 0.394793201346496 671 6710748
SGTC_1193 1488-0126 41.5 µM -0.267922485913753 0.42555557283383 no 1935 0.394379492496985 647 1384710
SGTC_1364 1653-0028 37.6 µM -0.270055474643669 0.424985134616093 no 1936 0.393558787937712 651 5718652
SGTC_2750 bromebric acid 70.15 µM -0.272893873385815 0.424226287997779 no 1937 0.392467398086879 695 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1842 st055362 61.2 µM -0.274740527075903 0.423732735274381 no 1938 0.391757796356294 649 676032
SGTC_2850 9015429 58.44 µM -0.276028304934945 0.423388623312515 no 1939 0.391263163127128 650 6457570
SGTC_2737 bleomycin 30.5 nM -0.276236990170803 0.423332865240654 no 1940 0.391183024024002 672 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3226 9131256 49.47 µM -0.276890684031675 0.423158216400303 no 1941 0.390932023052017 653 17178073
SGTC_1795 st049545 62.3 µM -0.276949614065427 0.423142472673756 no 1942 0.390909397724762 641 5291882
SGTC_2397 5161689 200 µM -0.277357388004854 0.423033535299468 no 1943 0.390752848987821 693 2259942
SGTC_553 k007-0256 45.7 µM -0.277685028561589 0.422946009932898 no 1944 0.390627077132202 676 6287000
SGTC_3219 9131112 49.47 µM -0.280112902617426 0.42229755038911 no 1945 0.389695442974418 669 17612988 YMR079W SEC14
SGTC_1140 3229-1848 2.98 µM -0.280702088997796 0.422140216605936 no 1946 0.389469453180076 693 2849525
SGTC_2329 6138490 200 µM -0.281767782125545 0.42185567009769 no 1947 0.389060788253702 706 720019
SGTC_1323 1348-1351 11.2 µM -0.281997048723116 0.421794459856813 no 1948 0.388972886643361 675 6989654
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.283855276368882 0.421298414856132 no 1949 0.388260645768549 682 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2353 9059630 146.67 µM -0.283877024249355 0.421292610101093 no 1950 0.388252312233228 674 4779114
SGTC_2270 7924575 90.91 µM -0.284856669746278 0.421031149408294 no 1951 0.38787697686312 694 1262135
SGTC_2642 cholecalciferol 100 µM -0.285496267724537 0.420860463859046 no 1952 0.387631981701469 691 9821465 A vitamin D precursor, similar to steriods.
SGTC_322 k048-0136 19.3 µM -0.286097683779948 0.420699981252227 no 1953 0.387401652760757 659 6823282
SGTC_2093 5331342 194.4 µM -0.286632632119334 0.420557246046556 no 1954 0.38719681277146 671 33839
SGTC_1659 st012954 42.1 µM -0.287608833218128 0.420296802474185 no 1955 0.386823091266147 703 24207262
SGTC_1681 tripelennamine 100 µM -0.289124312708464 0.41989255239805 no 1956 0.386243124442093 632 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.289188267865427 0.419875494387495 no 1957 0.386218654684971 673 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_978 1416-0512 87.4 µM -0.289549669431617 0.419779104806827 no 1958 0.386080388047902 694 6814003
SGTC_887 0885-0007 9.62 µM -0.291134025095257 0.419356597435189 no 1959 0.385474409092031 699 5719458
SGTC_3238 9133470 49.47 µM -0.29456246473228 0.418442638620022 no 1960 0.38416406965863 678 3534688
SGTC_1668 st014914 51.6 µM -0.297120878604607 0.417760899119633 no 1961 0.38318711246702 670 2839556
SGTC_2363 9053361 176 µM -0.298514556539738 0.417389630152953 no 1962 0.382655233889935 708 6469797 YMR079W SEC14
SGTC_2001 4023502 57.655 µM -0.30040579209509 0.416885932100072 no 1963 0.381933823074545 662 108941 YCR052W RSC6
SGTC_779 1360-0071 233 µM -0.300735984949374 0.416798004877604 no 1964 0.381807913130221 665 7566
SGTC_1155 4088-0394 48.2 µM -0.301009194150383 0.41672525500749 no 1965 0.381703741783066 678 2326248
SGTC_1038 k292-0204 154 µM -0.301177362982778 0.416680476598466 no 1966 0.381639625310448 664 4454212
SGTC_2445 5742597 35.57 µM -0.301469186809326 0.41660277507107 no 1967 0.381528371531113 668 1774255
SGTC_596 1155-0152 116 µM -0.302863849634537 0.416231474732607 no 1968 0.380996811013372 675 280313
SGTC_3185 9108267 49.47 µM -0.304225219018642 0.415869110174693 no 1969 0.380478156425958 699 4910486
SGTC_366 0181-0206 4.31 µM -0.306102762164006 0.415369469675939 no 1970 0.379763202453376 700 274874
SGTC_1374 2889-5571 141 µM -0.307481373650504 0.41500268893601 no 1971 0.379238499231541 665 2853281
SGTC_3250 9135583 49.47 µM -0.308019025856108 0.414859666176142 no 1972 0.379033927586567 664 7699353
SGTC_1427 4048-4900 550 nM -0.309343255322736 0.414507451385679 no 1973 0.378530215215893 704 24132586
SGTC_500 h-89 112 µM -0.310235975116964 0.414270047078308 no 1974 0.378190757501954 719 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2243 6634756 200 µM -0.310727642537422 0.414139309494727 no 1975 0.378003840534465 660 885676
SGTC_3102 9121669 49.47 µM -0.310947157329798 0.414080942146578 no 1976 0.377920396918834 661 41905072
SGTC_2101 5377231 179.231 µM -0.313807588891461 0.413320548636057 no 1977 0.376833590117519 716 2844213
SGTC_2585 alliin 100 µM -0.316466198374006 0.412614097182212 no 1978 0.375824338780152 721 87310 A garlic compound which reacts with lipids.
SGTC_2825 7998094 58.44 µM -0.318556827957775 0.412058769201374 no 1979 0.375031297672537 701 2987815
SGTC_3156 9099931 49.47 µM -0.321612222336802 0.411247490442752 no 1980 0.373873241665481 667 18111053
SGTC_563 tetrahydrosecaminediol 614 µM -0.322194109045939 0.41109302879635 no 1981 0.373652823520574 697 334274 A psychoactive constituent of the cannabis plant.
SGTC_2347 9049783 174.81 µM -0.322499061572859 0.411012084745491 no 1982 0.373537324284271 737 6467988 YPL169C MEX67
SGTC_1222 0366-0074 1.18 µM -0.322969894376538 0.410887118261756 no 1983 0.373359021037143 712 286520
SGTC_1452 4194-0072 190 µM -0.323014623682214 0.410875246865756 no 1984 0.37334208356656 707 1343545
SGTC_1365 1672-3266 55.4 µM -0.324603993044794 0.41045347283353 no 1985 0.372740402372106 709 6415873
SGTC_403 arphamenine a 50 µM -0.326380222072957 0.409982234025743 no 1986 0.372068349735486 721 5487158 An arginine aminopeptidase inhibitor.
SGTC_2137 5261020 140 µM -0.327377538792445 0.409717699888537 no 1987 0.371691176376255 685 763655
SGTC_1327 1436-0082 2.18 µM -0.329509726969515 0.409152283770402 no 1988 0.37088522151916 695 15992205
SGTC_1893 st059353 36.1 µM -0.329581041512748 0.409133375756919 no 1989 0.370858274796939 748 3112488
SGTC_567 1080-0542 68.4 µM -0.330494259180114 0.408891268082814 no 1990 0.370513264841958 669 5950415
SGTC_552 k242-0005 476 µM -0.333844859835758 0.40800327207968 no 1991 0.369248315124353 723 4088318
SGTC_1693 xanthone 101.9 µM -0.334022945464242 0.407956087952524 no 1992 0.369181122059979 709 7020 An insecticide.
SGTC_1690 st023502 41.2 µM -0.334071700953372 0.407943170325348 no 1993 0.369162726939313 702 24207482
SGTC_3297 9117502 71.43 µM -0.335402810216089 0.407590535444462 no 1994 0.368660624183387 677 7453720
SGTC_1122 capsaicin 818.572 nM -0.341330701492289 0.406021042872725 no 1995 0.366427318880646 727 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_918 glabranin 770.725 nM -0.341653192454219 0.405935701914312 no 1996 0.366305950765781 704 124049 Also referred to as licorice root.
SGTC_2805 7950783 58.44 µM -0.342381083219198 0.40574309622161 no 1997 0.366032061311117 680 1178958 YDL195W SEC31
SGTC_2870 9038528 12.99 µM -0.343195271311775 0.405527682604506 no 1998 0.365725780922077 709 6463316
SGTC_1641 st009299 47.1 µM -0.345118959235586 0.405018837102804 no 1999 0.365002470352183 681 4046054
SGTC_2630 antimycin a 100 µM -0.346926983498567 0.404540732776129 no 2000 0.364323087130801 719 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_202 3594-0513 34.79 µM -0.348481090811645 0.404129886754831 no 2001 0.36373945614226 691 708429
SGTC_2940 9060638 45.86 µM -0.348625142009518 0.404091810522073 no 2002 0.363685374997158 694 4027022
SGTC_2151 5563267 85.4165 µM -0.348828209018244 0.40403813651945 no 2003 0.363609142157614 713 5310824
SGTC_481 bay k-8644 50 µM -0.352663929793533 0.403024631878919 no 2004 0.362170201928902 750 2303 A calcium channel antagonist.
SGTC_486 niguldipine 82 µM -0.354085933322002 0.402649063886875 no 2005 0.36163724182807 683 1236 A calcium channel blocker.
SGTC_807 1315-0151 48 µM -0.354091919031347 0.402647483179669 no 2006 0.361634998979288 734 4011080
SGTC_3268 9137683 49.47 µM -0.355059235261187 0.402392055062439 no 2007 0.361272607531055 725 1953228
SGTC_1474 0330-0125 5.35 µM -0.356259934888158 0.402075058036642 no 2008 0.360822955404162 706 X1474
SGTC_813 k007-0158 173 µM -0.358445583089207 0.401498189925906 no 2009 0.360004942166818 694 6523916
SGTC_1160 4092-0570 10.5 µM -0.358686730326114 0.401434555956996 no 2010 0.359914728195405 693 4994975
SGTC_1907 st060210 83.7 µM -0.360284647982768 0.401012963329415 no 2011 0.359317139336968 710 688793
SGTC_110 0850-0284 111.64 µM -0.362921611441498 0.400317482366709 no 2012 0.358331721124392 687 3906265
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.36362025154578 0.400133273703839 no 2013 0.358070801005739 696 5106787 A p450 inhibitor.
SGTC_1062 mesoridazine 14.2 µM -0.364015966977536 0.400028946273583 no 2014 0.357923043124131 711 4078 A neuroleptic.
SGTC_3202 9113761 49.47 µM -0.364140378069092 0.399996147688492 no 2015 0.357876593129711 732 4798415
SGTC_1759 st043059 70 µM -0.364261640203135 0.399964179944208 no 2016 0.357831320851817 732 669426
SGTC_169 k015-0017 16.025 µM -0.367478535326673 0.399116371015089 no 2017 0.356631049953647 760 1840002
SGTC_2046 4110841 106 µM -0.36844691515306 0.398861248612093 no 2018 0.35627001039164 736 44119630 YMR134W ERG29
SGTC_3022 9087993 49.47 µM -0.368764870301765 0.398777491845625 no 2019 0.356151495734473 694 17173644
SGTC_2522 biochanin a 4.94 µM -0.372532355241857 0.397785404714681 no 2020 0.35474826336072 723 5280373 A possible chelator.
SGTC_1515 3460-0031 42.1 µM -0.373249238820868 0.397596703270558 no 2021 0.354481476215873 713 2876596
SGTC_392 N-ethylmaleimide 8.33 µM -0.374353651342401 0.397306041550736 no 2022 0.354070610481505 690 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1026 k007-1105 30.6 µM -0.377995333216092 0.396348020509444 no 2023 0.35271703039773 666 7066794
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.378497473440609 0.396215970900947 no 2024 0.352530535160826 714 756377
SGTC_3271 9137798 49.47 µM -0.378556497525087 0.396200449908347 no 2025 0.352508615900891 683 6498326
SGTC_707 0865-0008 204 µM -0.38098100328621 0.395563043531868 no 2026 0.351608672315866 709 723043
SGTC_3072 9116419 49.47 µM -0.382536608763622 0.395154219359218 no 2027 0.3510316900038 715 17170162
SGTC_1187 1391-0724 117 µM -0.383706241374829 0.394846907564637 no 2028 0.35059809307115 702 6997986
SGTC_1411 3909-8223 150 µM -0.383971827665545 0.39477713595577 no 2029 0.350499664111901 734 X1411
SGTC_2476 5806916 10.51 µM -0.384718096972553 0.394581103205521 no 2030 0.350223142920839 700 2870194
SGTC_38 0929-0051 58.268 µM -0.385610524614079 0.394346712098448 no 2031 0.349892568734256 732 1379719
SGTC_2035 5154463 94.595 µM -0.388613609572877 0.393558250102452 no 2032 0.348780998822511 746 2769623
SGTC_2908 7930301 100 µM -0.389910085014613 0.393217994226198 no 2033 0.348301518106176 733 2223178
SGTC_1672 st016598 6.51 µM -0.391283573459254 0.392857615494446 no 2034 0.347793819716013 736 4665860 YNL267W PIK1
SGTC_2055 5235184 200 µM -0.393566022877739 0.392258944919218 no 2035 0.346950735272104 766 2836034
SGTC_2948 9070189 9.45 µM -0.394665885894593 0.391970549443144 no 2036 0.346544741161998 728 6473636 YDL196W YDL196W
SGTC_1159 4092-0538 61.2 µM -0.394691522126239 0.391963828064754 no 2037 0.346535280120455 709 717301
SGTC_956 1185-0240 191 µM -0.395181128663166 0.391835467853406 no 2038 0.34635460939277 721 1416193
SGTC_476 mead acid 10 µM -0.395807726242926 0.391671209858494 no 2039 0.346123438311506 717 5312531 An omega 9 fatty acid.
SGTC_465 cgp-37157 41 µM -0.395882262038705 0.391651672126717 no 2040 0.346095943582133 702 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3308 9128332 17.569 µM -0.399329282903777 0.390748419434299 no 2041 0.344825296587352 715 17332805 YDL196W YDL196W
SGTC_1233 0325-0408 14.2 µM -0.40105429967299 0.390296619251439 no 2042 0.344190073231554 735 12874
SGTC_523 1934-0222 13.7 µM -0.40254819293386 0.389905472418536 no 2043 0.343640314129511 744 1361595
SGTC_1174 0739-0097 51.1 µM -0.403527748193732 0.389649055444035 no 2044 0.343280012953166 712 728447
SGTC_2439 5492030 7.2 µM -0.404352628746515 0.389433164722362 no 2045 0.342976714839142 720 5722370
SGTC_2216 7189485 200 µM -0.406233400114599 0.388941050122744 no 2046 0.34228555756352 717 731273
SGTC_2437 5741531 144.16 µM -0.406371790427669 0.388904846531102 no 2047 0.342234721876155 726 2262990
SGTC_2627 acetyl isogambogic acid 100 µM -0.409518513459641 0.388081909123813 no 2048 0.341079591631659 734 6857789 A caspase activator and apoptosis inducer.
SGTC_156 3474-0145 5.642 µM -0.410213880282018 0.387900123013477 no 2049 0.34082452984698 740 2265471
SGTC_271 rotenone 740 µM -0.410443910158124 0.387839992911564 no 2050 0.340740170487706 755 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2557 derrustone 83.84 µM -0.411347236071819 0.387603888400611 no 2051 0.340408968884174 767 629853 An antioxidant.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.412779529766773 0.387229611499396 no 2052 0.339884075218348 721 1241132 A phosphatase inhibitor.
SGTC_2967 9089538 49.85 µM -0.412849052709431 0.387211446918047 no 2053 0.339858604984879 746 728216
SGTC_2482 5981709 142.65 µM -0.412964129775823 0.387181380742458 no 2054 0.339816447274863 741 877755
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.415239337899352 0.386587076496812 no 2055 0.338983352030019 726 75037 A free radical scavenger.
SGTC_1736 st036774 51 µM -0.415714653805916 0.386462953358928 no 2056 0.338809408528706 758 1272247
SGTC_1393 3470-5649 58.2 µM -0.416165233577609 0.386345300495394 no 2057 0.338644549031926 740 4108395
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.419672328648213 0.385429905450587 no 2058 0.3373624211959 695 6708630 An antioxidant.
SGTC_3187 9109394 49.47 µM -0.420110827513795 0.385315496601701 no 2059 0.337202246636578 715 17098090
SGTC_2226 7298446 200 µM -0.421467293778375 0.384961643878873 no 2060 0.336706944501998 745 3283010
SGTC_2240 6690706 185.951 µM -0.421718220122491 0.384896196809841 no 2061 0.336615351883477 693 805876
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.423363238391526 0.384467221429896 no 2062 0.33601513095044 750 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_508 roscovitine 141 µM -0.426118750669488 0.383748976977652 no 2063 0.335010658858936 736 160355 A CDKinase inhibitor.
SGTC_622 1348-1566 26.3 µM -0.426479567392262 0.38365495696313 no 2064 0.334879216803409 724 7340407
SGTC_2319 6033012 152.6 µM -0.426635053531187 0.383614443189037 no 2065 0.334822580935943 710 847246
SGTC_1221 2958-7315 257 µM -0.427369787250084 0.383423016744883 no 2066 0.334555004822727 731 4562705
SGTC_3006 9075424 71.4286 µM -0.428277437153519 0.383186578263934 no 2067 0.334224571909655 734 7465181
SGTC_2772 vinpocetine 57.06 µM -0.428602147780488 0.3831020032526 no 2068 0.334106391122981 751 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_424 splitomicin 100 mM -0.430143628137061 0.382700581169632 no 2069 0.333545582701917 752 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2939 9044578 71.43 µM -0.43018391007135 0.382690092902911 no 2070 0.333530932646468 721 2653634
SGTC_1261 0712-0010 12.7 µM -0.430209519308573 0.382683425032727 no 2071 0.333521619006624 742 2840123
SGTC_697 0508-1955 564 µM -0.431172298475481 0.38243277172584 no 2072 0.333171547242618 752 6243113
SGTC_164 4100-3994 89.624 µM -0.431211080943233 0.382422675993289 no 2073 0.333157448767941 762 4615967
SGTC_958 1222-0007 33 µM -0.433240418793271 0.381894516667652 no 2074 0.33242005899663 751 7312461
SGTC_562 3772-2733 112 µM -0.433313568906121 0.381875482577868 no 2075 0.332393490912249 737 2876874 YIL048W NEO1
SGTC_1458 k015-0034 6.33 µM -0.433366786753224 0.381861635160355 no 2076 0.332374162745988 748 3598957
SGTC_1478 0453-0656 35.7 µM -0.434713509850253 0.381511264783681 no 2077 0.331885195470748 753 5258496
SGTC_822 1487-0950 154 µM -0.437577164032608 0.380766564831295 no 2078 0.330846414057567 728 1958375
SGTC_2876 9059903 25.97 µM -0.437961893131529 0.380666548714712 no 2079 0.330706953777616 741 6916095
SGTC_1938 st074717 56.4 µM -0.438708415809876 0.38047250167029 no 2080 0.330436414148624 715 17250979
SGTC_3321 9137793 26.8275 µM -0.438904985931808 0.380421411301736 no 2081 0.330365191915874 714 4904192
SGTC_1287 0971-0001 34.6 µM -0.439690917428729 0.380217161383214 no 2082 0.330080490850766 709 4665869
SGTC_2164 5685496 200 µM -0.441281649652929 0.37980386002143 no 2083 0.329504554584115 735 759046
SGTC_555 4296-0685 37 µM -0.441703020326055 0.379694403180348 no 2084 0.329352061899532 748 2908540 YHR072W ERG7
SGTC_1148 3909-7663 27.7 µM -0.441877136424596 0.379649176937422 no 2085 0.329289058131237 765 4084526
SGTC_941 3237-0776 460 µM -0.444011136059636 0.379095009523493 no 2086 0.32851726633381 756 760008
SGTC_1761 st044296 37 µM -0.444344477681241 0.379008468150372 no 2087 0.328396774454885 732 1826700
SGTC_1660 st012960 28.1 µM -0.444613919939941 0.378938520612476 no 2088 0.32829939310631 759 24207266
SGTC_3018 9082602 49.47 µM -0.445065350629672 0.378821337542895 no 2089 0.328136263965932 745 17332089
SGTC_2968 9090663 33.37 µM -0.445133497652017 0.378803648801875 no 2090 0.328111641182195 756 25236811
SGTC_14 0354-0009 295 µM -0.445714906681302 0.378652744334813 no 2091 0.327901597690241 748 1713507
SGTC_2182 6325192 200 µM -0.446486702615328 0.378452453609353 no 2092 0.327622857908721 715 736248
SGTC_2181 6316240 54.2555 µM -0.447512282758646 0.37818635322524 no 2093 0.327252610711396 726 12779990
SGTC_2888 9058547 12.99 µM -0.450218509266733 0.37748446447627 no 2094 0.326276445679326 721 16476514
SGTC_3135 9127742 49.47 µM -0.450845414908154 0.377321927414694 no 2095 0.326050483425587 725 3643468
SGTC_998 3996-0085 177 µM -0.452001172711045 0.377022332472036 no 2096 0.32563406880767 732 715391
SGTC_883 0850-0245 24.6 µM -0.452049078651165 0.377009915915362 no 2097 0.325616813192335 757 6823229 YPR165W RHO1
SGTC_84 0443-0269 128.823 µM -0.452417054975069 0.376914545786224 no 2098 0.325484281382898 749 6150058
SGTC_3258 9138477 49.47 µM -0.453558822787926 0.376618676353739 no 2099 0.325073198259588 735 4970355
SGTC_348 k064-0012 10.7 µM -0.454593644051215 0.376350582866344 no 2100 0.32470080411687 733 5066323
SGTC_1096 rimcazole 32.2 µM -0.456040418465273 0.375975863750708 no 2101 0.324180456847911 744 18528119 A dopamine reuptake inhibitor.
SGTC_2900 5328528 85.29 µM -0.456195279068837 0.375935761288827 no 2102 0.324124779961203 728 795359
SGTC_2891 9063876 19.48 µM -0.456430043239895 0.375874969678226 no 2103 0.324040382921577 754 6472478
SGTC_2808 7946468 45.46 µM -0.456590509784497 0.375833419029479 no 2104 0.323982700866247 768 2970879
SGTC_2605 digitonin 300 nM -0.457314945072335 0.375645854204226 no 2105 0.323722344589041 760 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2244 6635614 200 µM -0.458606282491008 0.375311584641584 no 2106 0.323258462143986 729 836499
SGTC_2155 5570423 76 µM -0.458998292284458 0.375210129329509 no 2107 0.323117696203423 752 797402
SGTC_2746 daunorubicin 9.88 µM -0.460055467363807 0.374936566897406 no 2108 0.322738203805976 739 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2095 5432005 200 µM -0.461297483306394 0.374615254055016 no 2109 0.322292595152912 787 783734
SGTC_588 3970-1144 52.9 µM -0.464602989485968 0.373760535392297 no 2110 0.321107895522884 723 1888707
SGTC_803 4488-1585 147 µM -0.465015942698746 0.373653799852823 no 2111 0.320960019854587 751 747204
SGTC_407 eburnamonine 100 µM -0.467944706805448 0.372897084087783 no 2112 0.31991206577481 752 3195
SGTC_2017 5132927 60.65 µM -0.470643925362276 0.372200110802945 no 2113 0.318947517156145 756 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2465 5809242 33.21 µM -0.471472559635843 0.371986230514926 no 2114 0.318651655371167 769 2731748
SGTC_548 1436-0017 110 µM -0.471533817590068 0.371970420680769 no 2115 0.318629787958028 760 9677137
SGTC_1461 k072-0203 53.8 µM -0.472135118561529 0.371815244645537 no 2116 0.318415173507257 750 5418714
SGTC_2132 5317594 122.667 µM -0.473336165010501 0.37150535635136 no 2117 0.317986682212079 754 794577
SGTC_1382 3002-2117 298 µM -0.473339885634699 0.371504396502858 no 2118 0.317985355201838 778 1497314
SGTC_1480 1070-0044 41.2 µM -0.474188185589624 0.371285572523003 no 2119 0.31768285874741 730 3124987
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.475011106098756 0.371073335072034 no 2120 0.317389528633831 700 4000243
SGTC_2784 7567673 72.73 µM -0.475540565915706 0.370936804087228 no 2121 0.317200863215838 751 3471247
SGTC_2275 7947463 200 µM -0.479335211927797 0.369958761003773 no 2122 0.315850087997094 771 1225414
SGTC_2957 9076800 11.52 µM -0.479637411506443 0.369880907256018 no 2123 0.315742619736052 761 16459615
SGTC_3137 9097352 49.47 µM -0.48061999656968 0.36962780701274 no 2124 0.315393300378651 811 44120435
SGTC_381 3461-2219 42.7 µM -0.481491523914452 0.369403360951964 no 2125 0.315083601222767 785 2883159
SGTC_2183 6420625 130.508 µM -0.485085343492238 0.368478308785781 no 2126 0.313807904108582 737 2897619
SGTC_433 pimozide 108 µM -0.48649797393668 0.368114904785707 no 2127 0.313307070741945 747 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_419 nsc-638432 893 µM -0.489079668308468 0.367451060151593 no 2128 0.312392647542148 749 368090
SGTC_2000 st075254 36.4 µM -0.492238254798357 0.366639414857421 no 2129 0.311275461951689 724 17234175
SGTC_719 2810-4230 27.3 µM -0.493804787082598 0.36623709218124 no 2130 0.310722026017527 757 721079
SGTC_815 1582-0027 36.9 µM -0.495245558672658 0.365867197585587 no 2131 0.310213397509363 743 3128206
SGTC_435 c-PAF 6.7 µM -0.499244016813322 0.364841312653109 no 2132 0.308803744476877 756 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1906 st060206 94.7 µM -0.49938882657728 0.364804176892465 no 2133 0.308752744563717 779 5133468
SGTC_968 1309-0633 340 µM -0.499837776311124 0.364689053976662 no 2134 0.308594654378116 781 3761976
SGTC_1684 st024538 14.6195 µM -0.501048700430596 0.364378600975143 no 2135 0.308168424514892 753 6732859
SGTC_2635 hydroquinidine 100 µM -0.504769265284307 0.36342529128213 no 2136 0.306860452558771 764 442912 An experimental heart treatment.
SGTC_1381 2324-0066 62.1 µM -0.510082880483781 0.362065265472525 no 2137 0.304996699150767 781 10885928
SGTC_3254 9136651 49.47 µM -0.510397963352509 0.361984674129447 no 2138 0.304886341716623 793 16454030
SGTC_2700 st077718 96.8 µM -0.511104582866731 0.361803958484725 no 2139 0.304638913533292 746 904970
SGTC_873 0591-4978 488 µM -0.514194650597726 0.361014046180002 no 2140 0.303557953713141 792 3305145
SGTC_3349 9149703 23.001 µM -0.514252586989583 0.360999241579397 no 2141 0.303537702914775 771 4910494
SGTC_879 0831-1030 162 µM -0.514300170398481 0.360987082652713 no 2142 0.303521071297852 773 1549252
SGTC_759 3486-0358 89.3 µM -0.514950073669608 0.360821027780443 no 2143 0.30329395425681 801 875103
SGTC_2859 9028643 45.46 µM -0.517965448467747 0.360050921917551 no 2144 0.302241188228507 761 17151580
SGTC_2060 5238662 140 µM -0.519762255465162 0.359592299530166 no 2145 0.301614644858128 777 790130
SGTC_2674 ligustilide 100 µM -0.519799398988522 0.35958282103664 no 2146 0.301601699143313 736 5319022 A signalling regulator.
SGTC_1892 st058411 7.36 µM -0.521175194709505 0.359231798636271 no 2147 0.301122366195616 796 3934738
SGTC_1358 1509-0022 2.48 µM -0.52160988929577 0.35912091474714 no 2148 0.300970988190532 774 3258434
SGTC_2024 5144227 134 µM -0.524946933302234 0.358270082096648 no 2149 0.299810040821665 753 3475211
SGTC_2819 7996655 46.38 µM -0.52589318668557 0.358028947485982 no 2150 0.299481211544947 761 6456960
SGTC_2946 9065502 71.43 µM -0.525966451138946 0.358010279799444 no 2151 0.299455758486168 756 16489101
SGTC_1654 st012436 41.8 µM -0.526101684956242 0.357975823292051 no 2152 0.299408779011077 773 4323132
SGTC_342 k048-0088 23.3 µM -0.527094542903935 0.357722886382113 no 2153 0.299063968076725 739 6820570
SGTC_2470 5664817 21.68 µM -0.530024008443845 0.356976950730765 no 2154 0.298047642495309 770 2859561
SGTC_412 gemfibrozil 100 µM -0.531287430093963 0.35665541163791 no 2155 0.297609807293706 757 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2807 7945238 51.95 µM -0.535305310700827 0.355633544342509 no 2156 0.296219377327522 784 17148797
SGTC_904 1141-0088 396 µM -0.539552434129651 0.354554500780339 no 2157 0.294752863630492 801 1378119
SGTC_3329 9141233 27.5565 µM -0.540128415361981 0.354408253971847 no 2158 0.294554237822592 791 4909101 YNL103W MET4
SGTC_1022 4477-0945 21.3 µM -0.540763193121801 0.354247103060084 no 2159 0.294335407734692 765 4648966
SGTC_2745 rifampicin 24.3 µM -0.541365774799657 0.354094149905233 no 2160 0.294127746247343 763 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.541771890115332 0.353991079033573 no 2161 0.293987829132587 788 364106
SGTC_499 genistein 192 µM -0.542051498943257 0.353920121354186 no 2162 0.293891514630003 789 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1838 st055369 84.5 µM -0.542311719600548 0.353854088462205 no 2163 0.293801891720918 737 676036
SGTC_3347 9188721 44.724 µM -0.543247980626111 0.353616541765503 no 2164 0.293479537576278 784 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2461 5755302 26.15 µM -0.543800230605592 0.353476452473371 no 2165 0.29328947506281 812 2788904
SGTC_2280 7785178 200 µM -0.545855699112125 0.352955216159285 no 2166 0.292582566255596 750 2954328
SGTC_92 0063-0024 660.874 µM -0.547908874147179 0.352434836777128 no 2167 0.291877237582225 781 3594437
SGTC_265 mycophenolic acid 32.932 µM -0.54865677962566 0.3522453478934 no 2168 0.291620506022149 789 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1085 doxorubicin 7.67 µM -0.548921840920495 0.352178200922204 no 2169 0.291529544397382 791 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_284 0988-0104 32.6 µM -0.549055271585987 0.352144401182064 no 2170 0.291483759731355 786 4666532
SGTC_2821 7996764 71.43 µM -0.549213132960756 0.352104414330732 no 2171 0.291429596377424 736 2987135
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.551963189640821 0.351408077853699 no 2172 0.290486786745879 787 4620898
SGTC_1116 jasmonic acid 1.58368 µM -0.552925847145368 0.351164442880352 no 2173 0.290157093830792 801 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_716 1683-5115 658 µM -0.555046532496925 0.350627943353713 no 2174 0.289431416417247 798 723597
SGTC_1482 3346-2049 8.48 µM -0.55521788725552 0.350584606324857 no 2175 0.289372817770699 771 3826804
SGTC_1355 1499-0035 1.68 µM -0.555332723643399 0.350555564345348 no 2176 0.289333549982847 784 1548538
SGTC_204 PMA1.184 62.41 µM -0.555500892505128 0.350513036225805 no 2177 0.289276049913458 779 2252213 YGL008C PMA1
SGTC_1057 3448-5381 134 µM -0.55565269841726 0.350474647731528 no 2178 0.289224149254366 765 5497911
SGTC_2840 9008771 71.43 µM -0.556525288541367 0.350254017831313 no 2179 0.288925905862792 742 2992978
SGTC_2058 5236698 133 µM -0.556719872778672 0.350204825100333 no 2180 0.288859418474293 751 766665
SGTC_2200 6600604 21.907 µM -0.556818256388388 0.350179953752121 no 2181 0.288825804570218 816 2904777
SGTC_3009 9080819 71.4286 µM -0.55763566255143 0.349973338565128 no 2182 0.288546599476043 790 17027216
SGTC_1290 0986-0249 10.2 µM -0.557767559478228 0.349940003230417 no 2183 0.288501558768956 796 53329
SGTC_77 0828-0286 12.516 µM -0.561429224943035 0.349015024621225 no 2184 0.287252482876666 774 745345
SGTC_1574 spiramycin 23.7 µM -0.564466188185579 0.348248532668809 no 2185 0.286218452424076 792 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1104 tacrolimus 29.8 µM -0.564669008301973 0.348197365411004 no 2186 0.286149458900484 777 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1255 0566-0045 221 µM -0.564796165474784 0.348165287734676 no 2187 0.286106207746209 778 2788469
SGTC_411 enrofloxacin 100 µM -0.565894866922551 0.34788816586204 no 2188 0.285732625600391 781 71188 A bacterial gyrase inhibitor.
SGTC_880 0833-0487 87.2 µM -0.567749532166349 0.347420554075111 no 2189 0.285102526465635 786 76075
SGTC_2917 7979103 53.79 µM -0.571978756989112 0.346355120015149 no 2190 0.283668183169444 787 2980565
SGTC_3257 9139206 32.98 µM -0.57249710657869 0.346224619827517 no 2191 0.283492622753868 785 4910041
SGTC_221 trifluoperazine 10.304 µM -0.574028440056784 0.345839196533235 no 2192 0.282974278042615 808 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_987 1497-1013 404 µM -0.574221268997918 0.34579067448153 no 2193 0.282909039184681 806 1676435
SGTC_1273 0849-0096 14.1 µM -0.576777225898847 0.345147751906175 no 2194 0.282044978030784 800 5286025
SGTC_1361 1608-0041 5.61 µM -0.578119627461629 0.344810264485973 no 2195 0.281591678295536 794 X1361
SGTC_254 nsc-64875 3.808 µM -0.579802662966523 0.344387314173984 no 2196 0.281023850795964 791 56993
SGTC_2076 5212012 200 µM -0.580074890223587 0.344318921162052 no 2197 0.280932057965614 783 604802
SGTC_215 1287-0124 461.5 µM -0.580448845686421 0.344224978765387 no 2198 0.280805986838042 787 5560863
SGTC_1017 4239-0030 168 µM -0.581876838268942 0.343866337228852 no 2199 0.280324821362637 767 1149593
SGTC_507 nimesulide 162 µM -0.582009874784459 0.343832932142995 no 2200 0.280280014734656 792 4495 A COX2 inhibitor.
SGTC_2760 etidronate 98.04 µM -0.582138276733929 0.343800691939478 no 2201 0.28023677231606 794 3305 A chelator and antioxidant.
SGTC_3086 9117350 49.47 µM -0.582246336120786 0.343773560391858 no 2202 0.280200383245146 777 2679265
SGTC_3169 9102970 49.47 µM -0.582743873000135 0.343648649229793 no 2203 0.280032866910001 796 17027839
SGTC_1787 fluconazole 80 µM -0.584203064783705 0.343282404336228 no 2204 0.279541849909047 781 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1636 st007707 68.9 µM -0.587088958657003 0.342558502699551 no 2205 0.27857198132787 811 403051
SGTC_1983 st071813 46.9 µM -0.588017378139359 0.342325739396275 no 2206 0.278260314194057 797 11838595
SGTC_2841 9004761 38.96 µM -0.590792118807331 0.3416304436077 no 2207 0.277329858139206 765 2991039
SGTC_354 2783-3500 4.88 µM -0.592236511094607 0.341268719493623 no 2208 0.2768461117561 797 6740761
SGTC_2643 anethole 100 µM -0.596075758110924 0.340307953243819 no 2209 0.275562309007121 826 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2466 5983409 37.09 µM -0.5966228430308 0.340171130164125 no 2210 0.27537960831502 788 2879657
SGTC_1464 k208-0027 110 µM -0.597366144567023 0.339985268053271 no 2211 0.275131476023459 804 X1464
SGTC_1413 3910-0535 34.4 µM -0.60067546918493 0.339158245863307 no 2212 0.274028080421089 790 2876951
SGTC_2965 9082772 38.63 µM -0.600759132591735 0.339137347842024 no 2213 0.274000213718624 751 16459634
SGTC_2716 st080858 38.6235 µM -0.601175028897834 0.339033469747675 no 2214 0.273861707294084 785 5296050
SGTC_960 1222-0186 7.7 µM -0.602718209771989 0.338648137661829 no 2215 0.273348082716312 809 3126296
SGTC_826 1683-5028 118 µM -0.603735333866895 0.338394254177918 no 2216 0.273009809270592 800 722377
SGTC_2241 6772625 37.8075 µM -0.604373240809948 0.338235064233734 no 2217 0.27279776118232 795 2285411
SGTC_496 calpeptin 138 µM -0.604495831138203 0.338204475077363 no 2218 0.272757020015785 779 73364 A calpain inhibitor.
SGTC_1966 st070145 16.1 µM -0.606438328102003 0.337719919265425 no 2219 0.272111861727965 807 3748532
SGTC_2671 danthron 100 µM -0.607479169433192 0.337460392001244 no 2220 0.271766481260263 798 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.607505603722568 0.337453801782835 no 2221 0.271757712460198 792 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2458 5808907 16.39 µM -0.611930078444755 0.336351459054318 no 2222 0.270292010038856 814 2731747
SGTC_2892 9047358 58.44 µM -0.613036315796465 0.336076063048605 no 2223 0.269926163715264 804 6466771
SGTC_1703 st026983 48.3 µM -0.613797082785763 0.335886722371826 no 2224 0.269674712612281 794 1104023
SGTC_180 1486-1293 102.781 µM -0.613927417726383 0.33585428861957 no 2225 0.269631645672748 802 4140536
SGTC_1790 st045711 43.5 µM -0.61673385044344 0.335156206847818 no 2226 0.268705144947612 764 585119
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.618600928281012 0.334692098457967 no 2227 0.268089645093287 824 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_847 0342-0274 5.54 µM -0.618798703516444 0.334642951303943 no 2228 0.268024488210319 801 18097
SGTC_3042 9091578 49.47 µM -0.619001734951377 0.334592500931003 no 2229 0.267957607971209 789 25236497
SGTC_3105 9121040 49.47 µM -0.620676976354978 0.334176341738339 no 2230 0.267406090489423 772 41448907
SGTC_1828 st055811 49 µM -0.624507140791845 0.333225628258158 no 2231 0.266147291110331 813 5877589
SGTC_1107 amlodipine 47 µM -0.625124597271161 0.333072464861648 no 2232 0.265944642679622 785 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2682 pyrogallin 40.03 µM -0.626244205026504 0.332794811166806 no 2233 0.26557738833887 798 822798 An ATP competetive kinase inhibitor.
SGTC_211 3455-0679 143.504 µM -0.628103607365768 0.332333896977442 no 2234 0.2649680350472 784 748649
SGTC_3263 9137018 49.47 µM -0.630635701978107 0.331706641486577 no 2235 0.264139374686527 812 43844957
SGTC_2785 7756463 72.73 µM -0.633804727646958 0.330922268663316 no 2236 0.263104133742015 840 2201551
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.634619278364763 0.330720777015026 no 2237 0.262838375850343 828 91467 include heat shock
SGTC_1912 st060209 90.8 µM -0.634662018458388 0.330710205949124 no 2238 0.262824435123694 835 688787
SGTC_1433 4060-0023 7.6 µM -0.6354943878351 0.330504359872473 no 2239 0.262553012910104 807 3840627
SGTC_1546 5-methoxyflavanone 78.7 µM -0.636039691370443 0.330369533357794 no 2240 0.262375276043279 801 147795
SGTC_1400 3771-8998 51.5 µM -0.636163894799724 0.33033882708876 no 2241 0.262334801650345 792 670767
SGTC_260 nsc-65238 3.989 µM -0.637289393584118 0.330060627062629 no 2242 0.261968179187861 799 3246252
SGTC_1031 k035-0009 16 µM -0.638281106796453 0.329815573913089 no 2243 0.261645354183312 816 5180959
SGTC_2845 9003024 42.97 µM -0.640317133300481 0.329312699051107 no 2244 0.260983222086862 784 2990173
SGTC_1534 6-azauridine 81.6 µM -0.640644506429426 0.32923187047333 no 2245 0.260876838190939 814 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1151 3909-8316 15.3 µM -0.641370748037937 0.329052589578328 no 2246 0.26064091676272 819 800431
SGTC_522 1273-0010 11.6 µM -0.642222725148772 0.328842319576554 no 2247 0.260364289885443 816 5705015
SGTC_2441 5730946 39.09 µM -0.642337551389168 0.32881398432444 no 2248 0.260327018733871 803 1774275
SGTC_1578 josamycin 24.2 µM -0.643123561196486 0.32862004998129 no 2249 0.260071963675369 811 5282165 A P450 substrate.
SGTC_1066 ketoconazole 628 nM -0.645397587054815 0.328059233437047 no 2250 0.259334783345945 831 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1243 0416-0003 5.65 µM -0.64552423379997 0.32802801140091 no 2251 0.259293759510522 815 2141977
SGTC_2143 5623677 140.463 µM -0.645725251003485 0.327978457392269 no 2252 0.259228652234759 797 5375313
SGTC_2517 totarol 10 µM -0.645967362447612 0.327918777005225 no 2253 0.259150246202029 794 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1686 st019653 115.5 µM -0.646474777995852 0.327793713504541 no 2254 0.258985963142233 838 97252
SGTC_3218 9131285 49.47 µM -0.648289570402031 0.327346576929042 no 2255 0.258398839218788 825 17156417
SGTC_638 3970-0837 4.09 µM -0.652610739247256 0.326282905857368 no 2256 0.257003630186932 812 4118451 YLR208W SEC13
SGTC_2112 5488546 200 µM -0.6537037241966 0.326014087029242 no 2257 0.256651351716641 834 600757
SGTC_1223 0764-0573 147 µM -0.655152884601244 0.325657806516276 no 2258 0.256184662825161 812 1609797
SGTC_1833 st055984 71 µM -0.655360438626144 0.325606791751027 no 2259 0.256117858188701 800 676288
SGTC_1168 k815-0004 80.5 µM -0.655546549988151 0.325561050161711 no 2260 0.256057962948509 832 642433
SGTC_1927 st060202 13.8 µM -0.659307162088757 0.324637347914825 no 2261 0.254849272096298 817 688887
SGTC_1870 st057514 26.5 µM -0.660155169843174 0.324429204267852 no 2262 0.254577128834804 825 5393161
SGTC_336 4111-0029 111 µM -0.661948096091174 0.323989310818522 no 2263 0.254002243214314 834 3131175
SGTC_536 3852-0578 10.6 µM -0.662640403790255 0.323819519224292 no 2264 0.253780443424457 824 2869208
SGTC_2178 5812956 200 µM -0.664533194749176 0.323355490880252 no 2265 0.253174555285519 818 5403383
SGTC_1887 st057648 70.8 µM -0.665071135713318 0.323223661716191 no 2266 0.253002497682386 829 688672
SGTC_1244 0416-0015 52.5 µM -0.665825312179417 0.323038878711159 no 2267 0.252761381918856 812 96201
SGTC_2853 9015042 58.44 µM -0.667248389623312 0.322690325259572 no 2268 0.252306743348381 803 6457456
SGTC_1312 1218-2183 165 µM -0.668261090307283 0.322442379950523 no 2269 0.251983472913544 824 6744073
SGTC_3144 9087057 49.47 µM -0.669298404697557 0.322188490183608 no 2270 0.251652572123714 836 17249618
SGTC_2036 5160441 105 µM -0.671524416705777 0.321643938662043 no 2271 0.250943255113454 825 134534 YIL048W NEO1
SGTC_1926 methyl fluorone black 53.6 µM -0.673299725428013 0.32120991756146 no 2272 0.250378313711169 794 72721 Reacts with homocysteine.
SGTC_3164 9100705 49.47 µM -0.673445378665935 0.321174319607429 no 2273 0.250331993662528 795 17174235
SGTC_2718 lomofungin 53.02 µM -0.674373954244076 0.32094741244653 no 2274 0.250036798677705 826 5351222 A RNA synthesis inhibitor.
SGTC_997 3996-0078 137 µM -0.674847488631213 0.320831725097551 no 2275 0.249886332822571 811 735687
SGTC_2377 9073351 62.6 µM -0.676752041944027 0.320366606839918 no 2276 0.2492816455002 849 7337946 YHR072W ERG7
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.677147147801126 0.320270151825104 no 2277 0.249156298636001 838 689007
SGTC_653 0203-0016 55.2 µM -0.677431200499141 0.320200815108043 no 2278 0.249066203972918 831 295302
SGTC_851 0394-0702 453 µM -0.68004624319444 0.319562783410064 no 2279 0.248237590416368 844 762646
SGTC_827 3253-0474 693 µM -0.680289048029199 0.319503569676167 no 2280 0.248160728891545 828 5402065
SGTC_3134 9127454 49.47 µM -0.680594607859354 0.319429058183912 no 2281 0.24806401988599 835 24262820
SGTC_2220 6782180 200 µM -0.681987267166564 0.319089547271374 no 2282 0.247623501086658 819 833803
SGTC_2777 climbazole 1.536 µM -0.682664862410685 0.318924413843652 no 2283 0.247409318865845 835 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2883 9059145 45.46 µM -0.683616283950987 0.318692608206637 no 2284 0.247108749623955 850 16476510
SGTC_1572 epiandrosterone 68.9 µM -0.683904711721674 0.318622349278917 no 2285 0.247017669286267 822 441302 A steroid.
SGTC_1237 0330-0133 46.1 µM -0.683973328669354 0.318605635644661 no 2286 0.246996003925005 850 X1237 YHR072W ERG7
SGTC_82 0054-0107 293.755 µM -0.684578793794351 0.318458173170702 no 2287 0.246804876269355 821 3104697
SGTC_2729 fluphenazine 10.66 µM -0.687819619333902 0.317669351739769 no 2288 0.245783189810282 838 3372 An atypical antipsychotic.
SGTC_2724 maprotiline 69.64 µM -0.687879265566022 0.317654841503698 no 2289 0.245764407339699 837 4011 A tricyclic antidepressant.
SGTC_1512 0259-0544 12.2 µM -0.688473366295775 0.31751032894289 no 2290 0.245577368363904 820 18476
SGTC_944 3370-0224 231 µM -0.689076551858192 0.317363634980963 no 2291 0.245387547488183 817 4580514
SGTC_3267 9137951 49.47 µM -0.690255682605337 0.317076954737263 no 2292 0.245016706061156 855 16643986
SGTC_2369 9071472 200 µM -0.690263389414541 0.317075081353452 no 2293 0.245014283230368 837 17296037
SGTC_1171 0368-0077 21.4 µM -0.690298049991332 0.317066656061604 no 2294 0.245003386958979 840 3239779
SGTC_1384 3089-0840 101 µM -0.692218654268087 0.316599943963136 no 2295 0.24440001281526 816 1069836
SGTC_1895 st058434 18.3 µM -0.692552996544792 0.316518727677702 no 2296 0.244295058239204 853 5393175
SGTC_1166 k206-0078 225 µM -0.694911141541286 0.315946153610983 no 2297 0.243555494977336 822 5404595
SGTC_1524 corynanthine 62.1 µM -0.696292297522208 0.315611004109681 no 2298 0.243122897948863 857 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1984 st072354 53.1 µM -0.697217496286475 0.31538658135592 no 2299 0.242833345529283 830 5762938
SGTC_1430 4049-0248 69.1 µM -0.69789286733559 0.315222801567628 no 2300 0.242622097680389 835 22774488
SGTC_1701 st028638 40.4 µM -0.701099583450093 0.314445657876045 no 2301 0.241620435140376 835 3490878
SGTC_1194 1488-0194 225 µM -0.701543699715794 0.314338091541102 no 2302 0.241481886448743 841 1391452
SGTC_142 0335-0849 62.6745 µM -0.703126075969444 0.31395496330039 no 2303 0.240988591523509 814 3889043 YPR107C YTH1
SGTC_3051 9093778 49.47 µM -0.704071663635054 0.313726111301595 no 2304 0.240694072862608 861 17217378
SGTC_797 k781-0471 270 µM -0.704727657577785 0.313567389135015 no 2305 0.24048986802988 831 23738129
SGTC_368 fentichlor 4.58 µM -0.704759299855002 0.313559733944494 no 2306 0.240480020468052 850 7329 A pesticide.
SGTC_861 0443-0273 110 µM -0.707254976041975 0.312956210158274 no 2307 0.239704019874161 845 6149169
SGTC_1695 st026914 34.495 µM -0.711942293041627 0.311824041493609 no 2308 0.238250255588326 841 3289191
SGTC_2306 7482397 179.52 µM -0.712171449640362 0.311768736747445 no 2309 0.23817930706583 873 891448
SGTC_1332 1480-0653 17.5 µM -0.712880568255709 0.311597624668992 no 2310 0.237959832223633 833 5749438
SGTC_3203 9113543 49.47 µM -0.717055294726364 0.310591078465345 no 2311 0.236669989384995 838 17018012
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.719978666420713 0.309887082362795 no 2312 0.235769065398964 843 1377
SGTC_1854 st056233 32.9 µM -0.720031422497878 0.309874384220846 no 2313 0.2357528244331 857 5393174
SGTC_1821 st053465 65.6 µM -0.720558959872854 0.309747420909195 no 2314 0.235590455908344 832 675086
SGTC_2998 9066762 71.4286 µM -0.721908469746823 0.309422735393507 no 2315 0.235175376791985 849 4945196
SGTC_1387 3342-1166 1.8 µM -0.72197928219624 0.309405702366939 no 2316 0.235153607620625 833 3418228
SGTC_2016 5121758 140 µM -0.72267167442441 0.309239177877365 no 2317 0.234940810972151 848 2795203
SGTC_2969 9091408 28.7 µM -0.723046996763135 0.309148926973051 no 2318 0.234825505615894 843 4286311
SGTC_1508 1080-0625 72.9 µM -0.724553066502235 0.308786889720766 no 2319 0.234363130318337 829 767111
SGTC_2958 9077254 16.72 µM -0.724615270155177 0.308771940859407 no 2320 0.234344044146501 837 16457351
SGTC_1943 st076331 65.2 µM -0.726256953504935 0.308377524005576 no 2321 0.233840631570457 846 24208415
SGTC_1418 3966-3099 2.4 µM -0.727314199198828 0.308123636161674 no 2322 0.233516750879161 835 740335
SGTC_3117 9124945 49.47 µM -0.727504988039734 0.308077829746495 no 2323 0.233458330406999 833 17592065
SGTC_1441 4106-0040 13 µM -0.727808986379673 0.308004849085487 no 2324 0.233365261387771 842 2904180
SGTC_2583 asiatic acid 100 µM -0.728312962856358 0.307883876545453 no 2325 0.233211014472525 863 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2529 gangaleoidin 93.61 µM -0.732933242673312 0.306775817016303 no 2326 0.231799573339344 857 4565183
SGTC_1723 st034307 2.5525 µM -0.73539070329838 0.306187173668839 no 2327 0.23105079104535 858 867466
SGTC_3328 9140624 29.0385 µM -0.737220515743593 0.305749197527307 no 2328 0.2304941296322 843 4904392
SGTC_3100 9120536 49.47 µM -0.738701362458386 0.305394951614768 no 2329 0.230044179140115 833 16421196
SGTC_2413 inermin 26.06 µM -0.738837398676325 0.305362418366646 no 2330 0.230002869638935 860 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_735 3076-0345 636 µM -0.739801724077727 0.305131842708203 no 2331 0.229710156367738 841 2888990
SGTC_711 k292-0785 179 µM -0.742492009375071 0.304488989258853 no 2332 0.22889464568849 842 4146315
SGTC_2820 7989630 71.43 µM -0.743522327427737 0.30424295072154 no 2333 0.228582754477778 796 2984098
SGTC_1486 3970-0793 4.53 µM -0.744052311931564 0.304116425648825 no 2334 0.22842241401591 867 2844330
SGTC_1868 st057644 42.7 µM -0.744139303907535 0.304095659987506 no 2335 0.228396101675003 855 688665
SGTC_2384 9036245 200 µM -0.746524226988663 0.303526606623485 no 2336 0.227675401076147 822 6462766
SGTC_3277 9138724 49.47 µM -0.746977244876448 0.303418568289251 no 2337 0.227538648299685 826 15943418
SGTC_2864 9034755 47.6 µM -0.752069688527153 0.302205276911386 no 2338 0.226004575616005 844 4930451
SGTC_1117 retinoic acid 1.10837 µM -0.753107538588151 0.301958273081949 no 2339 0.225692647351444 852 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1613 st002381 52.1 µM -0.754513896026274 0.301623710881278 no 2340 0.225270352235743 851 551167
SGTC_2427 5545055 42.75 µM -0.755888939928293 0.30129675923825 no 2341 0.224857892834204 848 5372858
SGTC_2150 5556613 200 µM -0.758433317634104 0.30069219004847 no 2342 0.224095809244892 875 743190
SGTC_2634 4'-methoxyflavone 100 µM -0.759095818389957 0.300534863230621 no 2343 0.223897620204836 855 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1028 k015-0029 4.8 µM -0.762023337604361 0.299840098534006 no 2344 0.22302303778385 862 4588309
SGTC_1209 2323-2347 50.3 µM -0.762918308751424 0.299627847415659 no 2345 0.222756058236292 839 5412760
SGTC_1796 st049173 110.4 µM -0.765534140439299 0.299007868095946 no 2346 0.221976772437203 877 94134
SGTC_328 k915-0120 63.5 µM -0.765625956391108 0.298986117346581 no 2347 0.221949447735677 845 6624543
SGTC_1063 disulfiram 1.84 µM -0.767025576963497 0.298654643089711 no 2348 0.22153315433493 877 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_417 st075190 100 µM -0.767575736997484 0.298524393622434 no 2349 0.221369640840889 867 222757
SGTC_724 3910-0327 137 µM -0.769084356521301 0.298167363128913 no 2350 0.220921617116793 873 2885483
SGTC_3154 9100113 49.47 µM -0.769232518127415 0.298132309635841 no 2351 0.220877644692061 872 25237525
SGTC_1239 0337-0584 35.4 µM -0.769481659014308 0.29807336972953 no 2352 0.220803714237496 879 914301 YML130C ERO1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.772707729652653 0.297310649804575 no 2353 0.219847685538766 869 390807
SGTC_775 4577-0580 57.3 µM -0.775812051648536 0.296577557187693 no 2354 0.218929983530173 862 2006902
SGTC_2707 st078556 66.6 µM -0.780285745383551 0.295522543502904 no 2355 0.217611350654314 845 17250899
SGTC_547 1120-0019 610 nM -0.780370835157335 0.295502493849046 no 2356 0.217586314718941 841 3676939
SGTC_391 gliotoxin 8.33 µM -0.783671446558862 0.294725255939666 no 2357 0.216616460508601 887 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_192 3455-0609 60.9 µM -0.785088996911021 0.294391736549853 no 2358 0.216200695247319 848 3769639
SGTC_334 1502-1024 68.5 µM -0.785946406886235 0.294190090864713 no 2359 0.215949442696101 865 3296216
SGTC_346 4513-0042 7.16 µM -0.786785391294104 0.293992840298543 no 2360 0.215703753350759 854 2827372
SGTC_2462 5162487 171.77 µM -0.789457612741905 0.293364991956248 no 2361 0.214922297221663 854 2259986
SGTC_1138 3761-0006 1.03 µM -0.793040389827158 0.292524181491542 no 2362 0.213877145568408 857 12061087
SGTC_1628 st004252 77.7 µM -0.794645468950527 0.292147863179814 no 2363 0.213409880609211 862 692968
SGTC_2616 abietic acid 100 µM -0.79495097799424 0.292076260683528 no 2364 0.213321009355179 873 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2694 st077685 81.9 µM -0.796268354803278 0.291767599200395 no 2365 0.21293803736949 865 2838096
SGTC_32 0928-0142 34.1 µM -0.796509614842061 0.291711088426261 no 2366 0.212867944637419 861 2244242
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.797833955883449 0.291400976526843 no 2367 0.212483426753531 891 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1529 apigenin 74 µM -0.800636292355443 0.290745280119604 no 2368 0.211671116982143 871 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2626 ethyl orsellinate 100 µM -0.801229614702499 0.290606541897946 no 2369 0.211499364823119 887 75653 A natural product.
SGTC_1667 st014849 34.6 µM -0.80178337540006 0.290477082438068 no 2370 0.211339138430181 871 5348460
SGTC_1629 st005085 44.9 µM -0.803159859576115 0.290155401772718 no 2371 0.210941171497155 867 24207091
SGTC_521 r062-0005 13.8 µM -0.807121927352929 0.289230410113538 no 2372 0.20979812008661 863 2832033
SGTC_2199 6590217 200 µM -0.808588860741564 0.28888828909507 no 2373 0.209375837115322 827 703109
SGTC_1080 nisoldipine 24.4 µM -0.808925947940042 0.288809699890831 no 2374 0.209278871266579 870 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_429 1112-0049 25.5 µM -0.809252385305973 0.288733603204255 no 2375 0.209184994125182 883 2836170
SGTC_2368 9071271 200 µM -0.810012258537373 0.288556503701385 no 2376 0.208966565166727 888 27209959
SGTC_2744 captopril 92.04 µM -0.811029865280592 0.288319415851932 no 2377 0.208674260079748 835 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_922 1866-0035 480 µM -0.813002187656767 0.287860154617208 no 2378 0.208108401947794 876 3156169
SGTC_3239 9133757 49.47 µM -0.813007826865095 0.287858842005954 no 2379 0.208106785361687 893 17036923
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.81320810144311 0.287812226893848 no 2380 0.208049377658246 889 521171
SGTC_3332 9141069 11.198 µM -0.814722798161529 0.287459787641278 no 2381 0.207615500230422 877 17332883
SGTC_1513 0337-0559 19 µM -0.816191661788984 0.287118207876065 no 2382 0.207195262520159 873 775073
SGTC_2740 felodipine 17.08 µM -0.81636064827171 0.28707892291348 no 2383 0.207146948257335 839 3333 L-type calcium channel blocker
SGTC_985 1493-0307 8.71 µM -0.817917051782961 0.286717219306224 no 2384 0.206702276458095 888 3278274
SGTC_1114 scopoletin 1.73284 µM -0.818064908878424 0.28668286899237 no 2385 0.206660062409081 881 5280460 A coumarin with genotoxic properties.
SGTC_2330 7979373 200 µM -0.818280657425699 0.286632749567359 no 2386 0.206598474121784 875 1863007
SGTC_1156 4092-0367 4.88 µM -0.819319354999552 0.286391513305627 no 2387 0.206302116294148 870 1357585
SGTC_1170 0310-0127 64.8 µM -0.819463478594873 0.286358048388684 no 2388 0.20626101533115 894 774975
SGTC_2943 9068529 45.32 µM -0.82132337669831 0.285926354187428 no 2389 0.205731047815355 890 3270634
SGTC_303 1348-1668 34.2 µM -0.821451411508372 0.285896647877429 no 2390 0.205694594769353 880 5380509
SGTC_2594 a-mangostin 100 µM -0.823781868269817 0.285356197832931 no 2391 0.205031755926628 885 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1253 0550-0034 176 µM -0.824208477940773 0.285257316632487 no 2392 0.20491055533957 877 5969915
SGTC_1272 0839-0021 27 µM -0.825380877804725 0.284985657477331 no 2393 0.204577693865065 895 5027250
SGTC_1591 genipin 88.4 µM -0.826257165195109 0.284782691747467 no 2394 0.204329113290468 901 442424 A DNA cross-linking agent.
SGTC_1967 st070177 51.4 µM -0.826266970236097 0.284780421093673 no 2395 0.204326332865994 886 5729214
SGTC_1102 cgs 12066b 26.1 µM -0.827763294520267 0.284434003255354 no 2396 0.203902282886158 861 6438352 A 5-HT1B full agonist.
SGTC_2575 plumbagin 510 nM -0.828592536963248 0.28424210997203 no 2397 0.203667506223064 870 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1279 0874-0590 65.2 µM -0.832754296553443 0.283279981700079 no 2398 0.202491657688915 887 3523074
SGTC_1439 4092-1168 46 µM -0.833634990248133 0.283076580660643 no 2399 0.202243350986249 898 2886240
SGTC_865 0488-0499 301 µM -0.834249221867784 0.282934762000974 no 2400 0.20207027965453 871 9634651
SGTC_2361 9034121 116 µM -0.834302634028919 0.282922431390738 no 2401 0.202055233961671 909 6496917
SGTC_1962 st076595 64.5 µM -0.834401174933252 0.282899683138511 no 2402 0.202027477694719 878 279619
SGTC_1334 1486-0610 236 µM -0.834611502154308 0.282851131857545 no 2403 0.201968241925737 852 3742339
SGTC_848 0368-0089 85.6 µM -0.83557435315892 0.282628921437767 no 2404 0.201697200943343 878 762535
SGTC_3340 9146634 11.102 µM -0.841864682088796 0.281179283766489 no 2405 0.199931850668492 850 4907387
SGTC_2685 mycophenolic acid 18.85 µM -0.843182096435793 0.280876134452154 no 2406 0.199563304909009 862 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_786 4544-0069 423 µM -0.8445180893525 0.280568871482571 no 2407 0.199189979664848 882 748821 YLR208W SEC13
SGTC_1739 st037196 92.5 µM -0.845579467564328 0.280324882726027 no 2408 0.198893691865572 882 612214
SGTC_931 2812-0076 566 µM -0.846326949264701 0.280153113930981 no 2409 0.198685188982543 888 3450959
SGTC_1341 1486-1360 280 µM -0.84876060925171 0.279594220604518 no 2410 0.198007256473297 909 3976547
SGTC_3151 9099821 49.47 µM -0.851607150822864 0.278941196020156 no 2411 0.197216084694458 881 17174189
SGTC_2795 7780010 54.55 µM -0.852482177219186 0.278740605575282 no 2412 0.196973263473477 893 953673
SGTC_2555 cholic acid 100 µM -0.852559998616536 0.27872276925278 no 2413 0.196951676678424 875 6708657 Influences liver metabolism.
SGTC_2794 7785382 27.27 µM -0.854386643673791 0.278304269882413 no 2414 0.196445396952122 873 2205081
SGTC_1621 st003705 32.4 µM -0.855333339846509 0.278087494603404 no 2415 0.196183317721669 877 24207032
SGTC_768 0384-0033 77.3 µM -0.855761695895581 0.277989436351594 no 2416 0.196064803208487 872 3965305 YMR134W ERG29
SGTC_259 usnic acid 108.925 µM -0.856036098990906 0.277926629512584 no 2417 0.195988906130858 906 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_101 0490-5701 117.494 µM -0.856332723958478 0.277858744204021 no 2418 0.195906882761566 867 4661669
SGTC_743 1275-0778 158 µM -0.856712424700868 0.277771858066882 no 2419 0.1958019175027 889 2849257 YMR203W TOM40
SGTC_2355 9061122 103.12 µM -0.856759930614805 0.277760988320508 no 2420 0.195788787272311 907 5302957
SGTC_2959 9079155 11 µM -0.857225579669291 0.277654454959704 no 2421 0.195660114128291 888 16189457
SGTC_2098 5376439 882.5 nM -0.857738453434159 0.27753714041345 no 2422 0.195518450773498 885 2844116
SGTC_1477 0139-0234 16 µM -0.860357810332546 0.276938367776947 no 2423 0.194795917369061 885 620880
SGTC_1913 st060213 96.1 µM -0.862217312829725 0.276513678513528 no 2424 0.194283972186485 900 688959
SGTC_3116 9124943 49.47 µM -0.863305449294405 0.276265308679258 no 2425 0.193984774444119 867 41905195 YPL160W CDC60
SGTC_3292 9120825 59.784 µM -0.864462044577205 0.276001433019246 no 2426 0.193667061032296 874 24824900
SGTC_2299 7976368 114.88 µM -0.868291141739445 0.275128713858768 no 2427 0.192617485149546 900 2979718
SGTC_1627 st003713 25.6 µM -0.869013553073405 0.274964216007578 no 2428 0.192419858883379 906 16195070 YER133W GLC7
SGTC_749 1000-0129 128 µM -0.870593855972926 0.274604539593532 no 2429 0.19198797618689 912 708470
SGTC_1015 4130-4525 82 µM -0.872217173815914 0.274235314793576 no 2430 0.191544956131964 895 1363237
SGTC_2158 5657123 3.6195 µM -0.872325624072646 0.274210656444852 no 2431 0.191515381280884 920 2858827
SGTC_2471 5466956 24.79 µM -0.873669119904618 0.273905276465287 no 2432 0.191149236229977 884 724419
SGTC_699 0375-0592 111 µM -0.875498749423049 0.273489667648495 no 2433 0.190651295187702 849 762578
SGTC_76 0433-0009 400.328 µM -0.876805053988129 0.273193125640777 no 2434 0.190296266761529 953 2841569
SGTC_995 3931-2021 34.6 µM -0.877829430084852 0.272960695242374 no 2435 0.190018145362574 909 730143
SGTC_1738 st035555 74 µM -0.878397174094503 0.272831916668778 no 2436 0.189864108705357 899 5331140
SGTC_2301 7769476 200 µM -0.878665717546033 0.272771014782397 no 2437 0.189791275975001 890 977820
SGTC_474 dl-dihydrosphingosine 5 µM -0.881306368243336 0.272172511739817 no 2438 0.189076010100932 858 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2092 5303694 80.6725 µM -0.883124745113132 0.271760756766024 no 2439 0.188584437891912 893 1963699
SGTC_1324 1418-0026 34.4 µM -0.884837561702485 0.27137318871861 no 2440 0.188122123795228 913 1372513
SGTC_1609 st001574 46.4 µM -0.885888971719567 0.27113541712515 no 2441 0.187838679726425 899 3960012
SGTC_1198 1612-1005 86.7 µM -0.887310906813933 0.270814018309575 no 2442 0.187455767538696 913 6998509
SGTC_1852 st056254 31.4 µM -0.890189188423165 0.270164025303732 no 2443 0.186682154497123 880 442583
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.890288810624918 0.270141541923539 no 2444 0.186655413876592 888 2333 A French combination drug.
SGTC_503 tyrphostin 8 294 µM -0.891430871946838 0.269883861051075 no 2445 0.18634903088897 935 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2285 7945142 200 µM -0.893623704047963 0.269389442179937 no 2446 0.185761629648625 891 2970608
SGTC_56 0957-0365 83.25 µM -0.894736535047868 0.269138705476233 no 2447 0.185463971727593 899 6752360
SGTC_1016 4226-1401 38 µM -0.894819080568695 0.26912011145851 no 2448 0.185441904409099 892 2901613
SGTC_2296 7971656 126.45 µM -0.895605487657335 0.268942999501195 no 2449 0.185231751894377 889 666570
SGTC_1946 st076057 65.1 µM -0.896401701388917 0.268763738561786 no 2450 0.185019129478396 879 953009
SGTC_3096 9117468 49.47 µM -0.897994762737505 0.268405254238957 no 2451 0.184594170801703 886 41316311
SGTC_2459 5811157 9.22 µM -0.898374065175525 0.268319935806947 no 2452 0.184493079132482 896 2870684 YBR192W RIM2
SGTC_1262 0737-0114 49.6 µM -0.898593047541717 0.268270685198431 no 2453 0.184434731643576 917 765919
SGTC_2693 st077581 40.7 µM -0.898941662128858 0.268192288814799 no 2454 0.184341867550095 876 25238761
SGTC_172 1112-0046 2.638 µM -0.899285620882906 0.268114950733879 no 2455 0.184250272196555 930 2802135 YIL048W NEO1
SGTC_934 2950-0684 338 µM -0.899658376431383 0.268031150457007 no 2456 0.184151040313315 906 1121253
SGTC_572 0960-0087 17.7 µM -0.900781673116324 0.267778698576098 no 2457 0.183852206825959 916 6796365
SGTC_2349 9023730 187.07 µM -0.901002055412676 0.267729183491703 no 2458 0.183793613421413 909 4126287
SGTC_3337 9144342 33.5465 µM -0.90162646250796 0.267588917926095 no 2459 0.183627664453483 878 17682949
SGTC_1024 4507-0395 26 µM -0.902542917985488 0.267383114305292 no 2460 0.183384266796724 894 4201836
SGTC_2818 7996756 12.99 µM -0.902787995594345 0.267328092040641 no 2461 0.183319211740246 933 2241621
SGTC_1603 st002045 67.8 µM -0.903862404809097 0.267086944342701 no 2462 0.183034183155923 915 5887985
SGTC_1225 1216-0074 20.6 µM -0.904089502587661 0.267035987040119 no 2463 0.182973972107068 902 4241466
SGTC_845 0330-0138 4.51 µM -0.908794954370862 0.265981260831962 no 2464 0.181729185225472 906 9039800
SGTC_2764 methyldopa 94.69 µM -0.908959597622354 0.265944394324896 no 2465 0.181685726417939 901 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3319 9138450 16.7555 µM -0.909816726009111 0.265752510100785 no 2466 0.181459586081564 886 2029690
SGTC_2328 6201408 200 µM -0.912353212439974 0.265185081627268 no 2467 0.180791405400158 929 2890418
SGTC_2861 9024595 19.48 µM -0.912561820770783 0.265138441985094 no 2468 0.180736520921668 871 16482810
SGTC_2809 7964133 12.99 µM -0.913310558147304 0.26497107721938 no 2469 0.180539615502092 928 1253665
SGTC_52 0329-0193 875 nM -0.915722248540238 0.264432358855038 no 2470 0.179906296346955 910 3739292
SGTC_1048 3161-0300 24.5 µM -0.918285841100214 0.263860320755289 no 2471 0.179234618983338 890 2165101
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.923444401187826 0.262711158716564 no 2472 0.177887830980525 873 88881 An O-methylated flavonoid and antioxidant.
SGTC_2409 alverine citrate 63.97 µM -0.924350547742579 0.262509562971933 no 2473 0.177651916529583 895 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_62 0180-0423 3.232 µM -0.924940727813227 0.262378304742581 no 2474 0.177498369886933 916 30102 YGL099W LSG1
SGTC_2526 patulin 37.61 µM -0.925269262147145 0.262305252056623 no 2475 0.177412931696979 912 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1288 0973-0013 65.5 µM -0.925808668368489 0.262185332629662 no 2476 0.177272710771014 903 4315430
SGTC_2955 9076254 12.21 µM -0.927173904031181 0.261881942461551 no 2477 0.176918124830684 894 16459619
SGTC_2866 9034245 58.44 µM -0.929903461927158 0.261275905395932 no 2478 0.176210535196219 893 6462273
SGTC_1731 st035964 63 µM -0.930054456727812 0.261242401433352 no 2479 0.176171444814779 939 6739575
SGTC_2292 7671323 168.05 µM -0.931603497301933 0.260898815158516 no 2480 0.175770737531029 921 937504
SGTC_1749 st037932 54.2 µM -0.933148823618819 0.260556284455843 no 2481 0.175371566818289 938 594497
SGTC_919 tnp00227 403.569 nM -0.936666203995673 0.259777500474788 no 2482 0.174465142850148 934 1269246 A methoxyflavone. YNL221C POP1
SGTC_1408 3909-7976 48.8 µM -0.93670162323037 0.259769664407084 no 2483 0.174456030523119 908 24152374
SGTC_2447 5741742 33.78 µM -0.936928084365145 0.259719565564551 no 2484 0.174397775881647 910 1776504
SGTC_1715 st032160 10.2275 µM -0.936978686231773 0.259708371853171 no 2485 0.174384760796129 899 5289825
SGTC_268 camptothecin 39.6153 µM -0.938548998604348 0.259361124605952 no 2486 0.173981174318187 927 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1666 st014829 29 µM -0.939527648764676 0.259144834553749 no 2487 0.173729951765548 915 3858230
SGTC_235 0330-0087 5 mM -0.941160426419374 0.258784184410927 no 2488 0.173311326600425 917 46494818 YHR062C RPP1
SGTC_594 1487-1584 10.8 µM -0.942846570256946 0.258412019482401 no 2489 0.17287969363681 932 5013332
SGTC_367 0335-0881 7.1 µM -0.943182360232211 0.258337937188998 no 2490 0.172793817222797 923 23828853
SGTC_1856 st057054 55.7 µM -0.943447881279803 0.258279365483857 no 2491 0.17272593094833 911 1266018
SGTC_1975 st070967 30.8 µM -0.944010625195182 0.258155251674203 no 2492 0.172582109342801 907 261391
SGTC_3060 1327-0027 12.5 µM -0.944919273555089 0.25795491354048 no 2493 0.172350045476554 894 16000455 YPR107C YTH1
SGTC_2456 5770359 74.46 µM -0.945402559811499 0.257848391801744 no 2494 0.172226697920705 919 3118787
SGTC_2641 levomentholum 100 µM -0.94654911308982 0.25759576987937 no 2495 0.171934292317329 897 16666
SGTC_3008 9078912 71.4286 µM -0.947167860448019 0.257459493697952 no 2496 0.171776624876101 932 16648731
SGTC_2253 7938677 135.83 µM -0.947420260861902 0.257403914456853 no 2497 0.171712335446984 927 2301972
SGTC_186 3455-3465 67.277 µM -0.949149435800368 0.257023313269093 no 2498 0.171272307149633 905 755278
SGTC_2376 9072922 81.32 µM -0.949387002778366 0.256971046313867 no 2499 0.171211909149934 929 17087968
SGTC_1891 st059073 26.2 µM -0.952643349884952 0.256255177262866 no 2500 0.1703854026196 909 688754
SGTC_2316 5844804 197.44 µM -0.953234666424643 0.256125295003282 no 2501 0.170235592808589 906 776813
SGTC_2360 9040895 200 µM -0.95476260783239 0.255789842791109 no 2502 0.169848880363264 928 4914414
SGTC_64 000l-0018 272.079 µM -0.960757321886898 0.25447595046325 no 2503 0.168337100978087 911 6811119
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.962074992915636 0.254187624532602 no 2504 0.168005967340597 903 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_993 3909-8757 62.7 µM -0.962254862855237 0.254148279619661 no 2505 0.167960798168341 911 4288324 YLR208W SEC13
SGTC_2419 paclitaxel 166.5 µM -0.96241273751766 0.254113748605746 no 2506 0.167921158920376 930 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1226 3909-7979 35.4 µM -0.971079894805072 0.252221813731906 no 2507 0.165754247381012 915 6615510
SGTC_1952 st077036 64.1 µM -0.973471369840952 0.251701094471769 no 2508 0.165159541404945 917 2937007
SGTC_255 tunicamycin 200.472 nM -0.975922186036109 0.251168043908294 no 2509 0.164551513401764 897 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2371 9071574 200 µM -0.977700276039908 0.250781684809488 no 2510 0.164111292607666 945 45596039
SGTC_773 4358-1457 44.6 µM -0.982955277309023 0.249641673509003 no 2511 0.162814725101111 949 1186886
SGTC_2380 9035439 200 µM -0.983997600032789 0.249415881323247 no 2512 0.162558346464079 925 6462575
SGTC_393 acivicin 6.25 µM -0.984425573488499 0.24932320341638 no 2513 0.162453154551882 901 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2027 5150920 200 µM -0.984706457157592 0.249262387842804 no 2514 0.16238414003017 897 786715
SGTC_844 0330-0132 15.3 µM -0.985842677561762 0.249016459406196 no 2515 0.162105159756146 924 2828079
SGTC_860 0443-0016 25.1 µM -0.986238576957243 0.248930799575773 no 2516 0.162008026526805 916 5337942
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.986623092926807 0.248847617765551 no 2517 0.161913722499889 945 6708561
SGTC_201 4262-0159 12.803 µM -0.98716997384213 0.248729337262692 no 2518 0.161779659457312 942 1341029
SGTC_1617 st002906 78 µM -0.987598947788985 0.248636578871792 no 2519 0.161674550908221 941 5150859
SGTC_1169 aniline yellow 25.8 µM -0.989441057345253 0.248238463243881 no 2520 0.161223697496296 918 6051 A DNA damaging agent.
SGTC_2115 tiliquinol 12.7705 µM -0.9916000986891 0.247772285522831 no 2521 0.160696320563561 929 71208 A bioactive hydroxyquinoline.
SGTC_1779 st039427 55 µM -0.991699962071697 0.247750734451991 no 2522 0.160671954784429 919 1124498
SGTC_3282 9108498 15.4605 µM -0.991788085007452 0.247731717865914 no 2523 0.160650455574231 940 16459645
SGTC_2802 7925815 54.55 µM -0.99220964738711 0.247640757131244 no 2524 0.160547633675568 937 1262923
SGTC_1675 st018485 24.5 µM -0.99238157472038 0.247603665402583 no 2525 0.160505711787304 934 3323024
SGTC_2582 agaric acid 100 µM -0.993856354477107 0.247285617284269 no 2526 0.160146402778584 907 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2567 aureobasidin a 60 nM -0.995633885709872 0.246902568840787 no 2527 0.159714032100634 922 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2492 derrusnin 100 µM -0.995788466090633 0.246869272613459 no 2528 0.159676467756027 945 1715307 Part of coumarin class of compounds.
SGTC_1661 st013063 9.66 µM -1.00084045240006 0.245782411427823 no 2529 0.158451974514531 950 721395
SGTC_2709 st078560 56 µM -1.00133376782607 0.245676419645088 no 2530 0.15833273638947 936 17250903
SGTC_510 ag-490 170 µM -1.00300164298229 0.245318248501694 no 2531 0.157930034263898 927 5328779
SGTC_2418 pentamidine 31.67 µM -1.00327147505058 0.245260329270838 no 2532 0.157864947592681 888 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2157 5649910 96.377 µM -1.00423511667553 0.245053544413154 no 2533 0.157632649693832 935 2858091
SGTC_2774 tamoxifen 10.92 µM -1.00440433283364 0.245017242526865 no 2534 0.157591881209024 923 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_327 1273-0057 3.96 µM -1.00497778687994 0.244894241138064 no 2535 0.157453773040379 910 3108138
SGTC_1270 0831-1170 17.3 µM -1.00687100450729 0.244488396879319 no 2536 0.15699838375177 919 6764716
SGTC_2664 lyso-paf C-16 73.48 µM -1.00688241915906 0.244485951048782 no 2537 0.15699564073347 932 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1760 st045453 10.4495 µM -1.00759155267267 0.244334030047221 no 2538 0.156825292952867 938 3323419 YIL048W NEO1
SGTC_1392 3455-1037 33.9 µM -1.00764473002054 0.244322639665478 no 2539 0.15681252361496 894 981132
SGTC_2131 toluylene red 5.2905 µM -1.01052619277377 0.243705869641091 no 2540 0.156121628459511 896 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1401 3807-4679 7.6 µM -1.01086522677938 0.243633355556012 no 2541 0.156040469558657 930 3291456
SGTC_24 0417-1663 219 µM -1.01230716474115 0.243325077713901 no 2542 0.155695605106456 964 4329390
SGTC_715 0868-0130 184 µM -1.01611100943578 0.242512850710586 no 2543 0.154788263471608 971 2876258
SGTC_212 3807-4682 38.772 µM -1.01850415866708 0.242002600098489 no 2544 0.154219212755359 931 3125501 YBL034C STU1
SGTC_891 0929-0073 133 µM -1.01928456845178 0.241836332547354 no 2545 0.154033943953703 944 5603632
SGTC_34 0469-0683 81.75 µM -1.02157580634151 0.241348538994759 no 2546 0.153490856639933 938 3690923
SGTC_1182 1222-0449 220 µM -1.0223784939756 0.241177777177117 no 2547 0.153300897601849 934 658318
SGTC_2002 4023503 131 µM -1.02244877878761 0.241162828084577 no 2548 0.153284271857225 956 4736863 YCR052W RSC6
SGTC_2830 7992007 71.43 µM -1.02319368185446 0.241004423325385 no 2549 0.153108139818892 931 1952075
SGTC_2556 citropten 84.59 µM -1.02485320122269 0.240651727567744 no 2550 0.152716229603893 917 2775 A potential DNA crosslinker.
SGTC_2881 9058953 51.95 µM -1.0264972143238 0.240302604555263 no 2551 0.152328638006449 904 17122249
SGTC_3236 9132701 49.47 µM -1.02910017503063 0.23975040400571 no 2552 0.151716301968243 950 24282524
SGTC_1212 0520-0165 585 µM -1.03370137740711 0.238775985965268 no 2553 0.150637894487545 973 5403258
SGTC_1559 coumarin 343 70.1 µM -1.03415892703174 0.23867920712436 no 2554 0.150530935973986 936 108770 A hepatotoxic, DNA x-linker.
SGTC_1179 1021-1431 9.29 µM -1.03528494100905 0.238441129141043 no 2555 0.150267930209004 957 2840958
SGTC_2051 5263410 176 µM -1.03540890861463 0.238414926084457 no 2556 0.150238993525207 931 227584
SGTC_2863 9028737 58.44 µM -1.03595522810028 0.238299469217785 no 2557 0.150111515150828 931 6460917
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.03595845232887 0.238298787913767 no 2558 0.150110763022332 943 6857784
SGTC_87 0100-0052 35.5 µM -1.03696908553714 0.238085286020755 no 2559 0.149875132439869 958 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_463 ikarugamyin 104 µM -1.0384519702028 0.237772208228742 no 2560 0.149529842499082 971 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2332 7982454 138.89 µM -1.03874553403615 0.237710255606571 no 2561 0.149461549115509 949 2981748
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.03961541378344 0.237526731419952 no 2562 0.149259306423622 953 65057 A dermal irritant. YDR527W RBA50
SGTC_2312 7706453 155.7 µM -1.04225542006396 0.236970228579962 no 2563 0.148646637440565 934 976098
SGTC_3233 9132340 49.47 µM -1.04230013311992 0.236960809421139 no 2564 0.1486362753343 964 17682950
SGTC_2598 perillyl alcohol 100 µM -1.04465806752227 0.236464383582981 no 2565 0.148090515817937 949 10819 An apoptosis inducer.
SGTC_2990 9074105 71.4286 µM -1.04629658438236 0.236119757104534 no 2566 0.147712060954088 943 6502001
SGTC_734 2023-0417 80 µM -1.04727856703988 0.235913351029077 no 2567 0.147485559128666 963 3935732
SGTC_1514 1189-1591 158 µM -1.04818054476222 0.23572384910714 no 2568 0.14727771619234 948 767698 YMR146C TIF34
SGTC_3056 9094900 49.47 µM -1.04986557758718 0.235370055428961 no 2569 0.14688995986868 946 25236784
SGTC_3071 9117417 49.47 µM -1.0516986893702 0.234985503817437 no 2570 0.146468906258791 943 45595590 YGL055W OLE1
SGTC_1420 4'-methoxyflavone 42 µM -1.05290031395443 0.234733614558575 no 2571 0.146193341105135 930 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2713 st079149 53.4 µM -1.05355068970398 0.234597342532681 no 2572 0.146044337610146 927 3103253
SGTC_1490 4089-0339 670 nM -1.05547633076733 0.234194123202196 no 2573 0.145603764534697 932 742542
SGTC_3327 9140648 26.9345 µM -1.05923961964583 0.233407218706831 no 2574 0.144745332810194 947 8029710
SGTC_1047 2043-3044 82 µM -1.05981689989762 0.233286639183317 no 2575 0.144613953418744 983 669592
SGTC_1071 trifluoperazine 6.31 µM -1.0606186519032 0.233119230439734 no 2576 0.144431621283288 973 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_86 0417-1630 471.922 µM -1.06146057815407 0.232943504984916 no 2577 0.144240319660274 933 3634867
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.06403491597987 0.232406650145125 no 2578 0.14365644126108 950 165506
SGTC_2415 st077333 57.7 µM -1.06440415974285 0.232329704174807 no 2579 0.143572825094179 915 2766255
SGTC_603 3794-0023 45.9 µM -1.06605515842259 0.231985829272488 no 2580 0.143199354222878 963 3802260
SGTC_261 5-fluorouridine 15.376 µM -1.06625185492413 0.231944879643483 no 2581 0.143154903476351 951 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_614 0462-0418 107 µM -1.06690815107243 0.231808276528341 no 2582 0.143006656869361 921 5188303
SGTC_1990 st072050 59.8 µM -1.06781596835706 0.231619395071363 no 2583 0.142801766773365 932 17233948
SGTC_754 3474-0146 171 µM -1.06870196003359 0.23143513741151 no 2584 0.142601994033409 933 24762078
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.07015935762086 0.231132223649952 no 2585 0.142273792397799 967 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1518 st038567 90.8 µM -1.07210498810941 0.230728177854356 no 2586 0.141836439337889 956 77966
SGTC_3320 9137005 35.139 µM -1.07315482357747 0.230510324288683 no 2587 0.141600828194155 948 4908713
SGTC_1612 st002233 45.4 µM -1.07604534067697 0.229911101446466 no 2588 0.1409534895627 925 1035021
SGTC_1284 0929-0043 16 µM -1.07609897992272 0.229899989931553 no 2589 0.140941495919012 948 1239883
SGTC_1390 3413-2614 145 µM -1.07831900209668 0.229440370107526 no 2590 0.140445709931084 965 3421432
SGTC_2491 paeonol 100 µM -1.07915186083884 0.229268073053123 no 2591 0.140260017732518 968 11092 Increases levels of cortical cytochrome oxidase.
SGTC_148 3253-0744 288.01 µM -1.08169308378026 0.228742807998567 no 2592 0.139694463682801 930 6893655
SGTC_3160 9100216 49.47 µM -1.08516661000273 0.228025932100628 no 2593 0.138923934910063 937 17191039
SGTC_1347 1493-0251 600 nM -1.08527615176102 0.22800334514356 no 2594 0.138899682534476 893 3986378
SGTC_413 propylparaben 100 µM -1.08728722733706 0.227588895223458 no 2595 0.138454945793855 944 7175 A pharmaceutical preservative.
SGTC_349 k015-0014 24 µM -1.08757117672118 0.227530412074238 no 2596 0.138392230437848 947 2196908
SGTC_2983 9022671 12.99 µM -1.08974195059644 0.227083592114485 no 2597 0.137913415604311 937 6405161
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.09190693328329 0.226638457319904 no 2598 0.137437004966941 955 6728940
SGTC_899 1083-0020 478 µM -1.09360876236315 0.226288895971733 no 2599 0.13706330228462 960 767123
SGTC_866 0495-0101 262 µM -1.0949788762991 0.226007691463842 no 2600 0.136762945460672 933 635694
SGTC_3333 9141820 12.094 µM -1.09718342345241 0.225555641379925 no 2601 0.13628060898242 935 1939433
SGTC_229 benomyl 22.8748 µM -1.09790821137283 0.225407132936251 no 2602 0.136122285998405 944 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2071 5230951 39.92 µM -1.09918719884384 0.225145204547348 no 2603 0.135843210609543 960 1799272
SGTC_871 0574-0004 149 µM -1.09973416509379 0.22503324204528 no 2604 0.135723982126946 964 9551173
SGTC_1350 1495-0454 146 µM -1.10160199507163 0.224651140267544 no 2605 0.135317370302259 950 1069057
SGTC_758 0868-0029 16 µM -1.10377936737091 0.22420618035786 no 2606 0.13484442856604 925 762687
SGTC_2781 5567276 71.43 µM -1.10440580197445 0.224078257216819 no 2607 0.134708572547506 950 2853274
SGTC_2214 7179297 48.276 µM -1.10537081891005 0.223881273906172 no 2608 0.134499471411947 963 769744
SGTC_1945 st075991 56.6 µM -1.105586209792 0.223837320852155 no 2609 0.134452830666382 963 1084980
SGTC_1329 1447-1697 50.6 µM -1.10675922915473 0.223598038495909 no 2610 0.13419901994635 962 2840515
SGTC_748 act1.228 77.9 µM -1.10870123235207 0.223202212301833 no 2611 0.133779545056964 957 4421505 YNR035C ARC35
SGTC_686 1319-0111 510 µM -1.10934397082491 0.223071294904374 no 2612 0.133640911549076 964 4562600
SGTC_1552 6-methylflavone 10.6 µM -1.11230446178749 0.222468846578165 no 2613 0.133003633070692 957 689013
SGTC_2245 6637752 200 µM -1.11392570743873 0.22213932302202 no 2614 0.1326555298836 969 681890
SGTC_2386 9075165 157.42 µM -1.11405800121567 0.222112446172159 no 2615 0.132627152355335 954 16452277
SGTC_2504 purpurogallin 52.29 µM -1.11458830789578 0.222004727516671 no 2616 0.132513441496079 949 5281571 An antioxidant.
SGTC_640 3381-0960 37.1 µM -1.11679618309675 0.221556573127749 no 2617 0.132040740612185 956 1745025
SGTC_2134 5324836 1.464 µM -1.11744385347521 0.221425207185547 no 2618 0.131902296766761 977 699272
SGTC_1719 st032227 49.2 µM -1.11833396115264 0.221244740754625 no 2619 0.131712193751317 944 3125804
SGTC_577 r071-0003 38.6 µM -1.11903838389241 0.221101980996223 no 2620 0.131561882109002 993 4568517 YMR134W ERG29
SGTC_1727 st034309 9.9045 µM -1.11972606770258 0.220962664443297 no 2621 0.131415256517348 975 870305
SGTC_230 MPP+ 141.667 µM -1.12149770253685 0.220603983879498 no 2622 0.131038034456007 968 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3195 9113082 49.47 µM -1.12349634518733 0.2201997446062 no 2623 0.130613375971444 961 17018038
SGTC_874 0599-0792 117 µM -1.12362851517494 0.220173027296584 no 2624 0.130585326940645 959 765305
SGTC_1306 1185-0270 9.02 µM -1.12439135361822 0.220018860765606 no 2625 0.130423519243264 956 1548076
SGTC_3097 9117246 49.47 µM -1.12629431779416 0.219634549549427 no 2626 0.130020481061969 946 16423892
SGTC_1455 4262-0120 131 µM -1.12959049844842 0.21896978567458 no 2627 0.129324408262569 952 1529587
SGTC_2938 9059746 27.26 µM -1.12987921267308 0.218911613826358 no 2628 0.129263562121354 972 6471769
SGTC_895 0964-0006 13.7 µM -1.13273878285548 0.218335931009825 no 2629 0.12866198295323 972 6738897
SGTC_1923 st058458 19.1 µM -1.13419849394623 0.218042401497879 no 2630 0.128355647814566 977 3534982
SGTC_751 0833-0568 350 µM -1.13614966013753 0.217650402047647 no 2631 0.127946967207315 965 6954252
SGTC_1203 3992-3522 103 µM -1.1375970502091 0.217359876743629 no 2632 0.127644389465438 977 5322312
SGTC_2224 6650123 117.647 µM -1.13913076302677 0.217052268927716 no 2633 0.127324309115824 982 2908370
SGTC_726 3448-4391 34.2 µM -1.13983259483371 0.216911590560803 no 2634 0.12717802569058 967 1356692
SGTC_2988 9073640 71.4286 µM -1.13991542243217 0.216894991697176 no 2635 0.127160769578404 974 9102229
SGTC_2588 indole-3-carbinol 100 µM -1.14268857060002 0.21633966966123 no 2636 0.126583958428367 965 3712 Induces cell cycle arrest.
SGTC_1436 4092-1007 8.32 µM -1.14409823612716 0.216057700390877 no 2637 0.126291449557123 928 2881121
SGTC_2663 amphotericin b 100 µM -1.1461390930442 0.215649854071999 no 2638 0.125868802183687 965 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2499 avocadenofuran 51.48 µM -1.14717535356338 0.215442938007462 no 2639 0.125654577809213 963 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_538 2922-0838 53.3 µM -1.14912574790881 0.215053804144634 no 2640 0.125252066363424 986 777039
SGTC_646 4092-0839 27.3 µM -1.14964863009239 0.214949550466171 no 2641 0.125144310064752 964 877796
SGTC_1450 4112-4260 37.6 µM -1.15001881671481 0.214875759395662 no 2642 0.125068060635039 952 1633175
SGTC_1475 4092-1048 11.7 µM -1.15089807827656 0.214700550975767 no 2643 0.124887084245479 983 2881759
SGTC_131 0141-0277 33.849 µM -1.1528256643713 0.214316735985993 no 2644 0.124490974066201 976 1547771
SGTC_1757 st041620 31.8375 µM -1.15317259734982 0.214247698166359 no 2645 0.124419774296322 996 5289815
SGTC_19 0279-0214 38.434 µM -1.15332914178492 0.21421655089183 no 2646 0.124387656586589 968 3566274 YBR002C RER2
SGTC_1699 st031318 29.054 µM -1.15482699374434 0.213918660067994 no 2647 0.124080640318016 958 5340658
SGTC_2804 7954240 19.48 µM -1.15586807137672 0.213711754065543 no 2648 0.123867562133446 954 828705
SGTC_1976 st070609 63.5 µM -1.15696348379808 0.213494175356041 no 2649 0.123643639866249 948 682556
SGTC_3037 9091026 49.47 µM -1.15806390318183 0.213275732166186 no 2650 0.123418979640578 957 25236398 YIL048W NEO1
SGTC_564 3555-0129 330 µM -1.15909402907657 0.213071361021732 no 2651 0.123208929729725 928 563260
SGTC_1807 st050092 58.9 µM -1.16109894526231 0.212673924730172 no 2652 0.122800831815609 976 5008496
SGTC_1925 st057770 10.1 µM -1.16491476985051 0.21191870757219 no 2653 0.122026747138619 967 5989122
SGTC_2228 7354201 200 µM -1.16696921085517 0.211512748974501 no 2654 0.121611401831212 986 753451
SGTC_161 4065-0411 162.148 µM -1.16738879297535 0.211429895361269 no 2655 0.121526697450366 970 1906281 YLR208W SEC13
SGTC_5 0352-0601 109.883 µM -1.17339439048065 0.210246072700958 no 2656 0.120318842841414 963 762456
SGTC_798 1287-0182 476 µM -1.17370746921529 0.210184465598211 no 2657 0.120256108733656 992 1649755
SGTC_2127 5253358 187.912 µM -1.1739959676791 0.210127704747661 no 2658 0.120198320377729 968 20612
SGTC_1863 st057641 20.1 µM -1.17415710046321 0.210096006474411 no 2659 0.120166052817949 995 3921635
SGTC_2797 7859098 81.82 µM -1.1750328013046 0.209923786469027 no 2660 0.119990796538447 945 972681
SGTC_685 1278-0033 54.9 µM -1.17534095506507 0.209863203044902 no 2661 0.119929167802791 964 3590572
SGTC_837 0091-0265 12.5 µM -1.17640415328177 0.209654255826988 no 2662 0.1197167064329 971 759367
SGTC_2170 morpholine 200 µM -1.17953303580063 0.209040055980409 no 2663 0.119092994998148 972 121171 Reacts with secondary amines.
SGTC_345 1362-0200 395 µM -1.18010027316753 0.20892882082514 no 2664 0.118980168000012 996 1419823
SGTC_2428 5615643 7.78 µM -1.18031868410657 0.20888599977484 no 2665 0.118936744855155 963 2253075
SGTC_675 1309-0189 238 µM -1.18043410018794 0.208863373702344 no 2666 0.118913803046506 961 4246530
SGTC_1864 st057645 30.4 µM -1.18197587749062 0.208561263466084 no 2667 0.118607636257456 974 688666
SGTC_584 0986-0246 15.4 µM -1.18500623362463 0.207968218596839 no 2668 0.118007491128011 997 53315 YDR232W HEM1
SGTC_1806 st050005 60.3 µM -1.18648261117214 0.207679650526961 no 2669 0.117715882278005 960 5194765
SGTC_1446 4239-0190 62 µM -1.18672062875326 0.207633150518429 no 2670 0.117668917669537 993 1340085
SGTC_2915 7971052 15.16 µM -1.18969764742695 0.207052068799607 no 2671 0.117082625191344 931 5741558
SGTC_1878 temozolomide 1 mM -1.19142016808055 0.206716291330811 no 2672 0.116744339677211 954 5394 DNA alkylating agent.
SGTC_2037 5169046 200 µM -1.19159743800798 0.20668175374065 no 2673 0.11670956503538 973 5718022
SGTC_49 0717-0965 32.132 µM -1.19311760586191 0.206385718981663 no 2674 0.116411658643693 985 5889349 YGL099W LSG1
SGTC_2817 7995342 71.43 µM -1.19331435006831 0.206347423739894 no 2675 0.116373142259169 995 18879975
SGTC_1172 0370-0043 85 µM -1.19872331697611 0.205296246488258 no 2676 0.115317774195762 988 376585
SGTC_3302 9125395 16.351 µM -1.19929899162366 0.205184557627399 no 2677 0.115205853533023 965 17599668
SGTC_2963 9082507 9 µM -1.19957803985382 0.205130431397894 no 2678 0.115151629743863 988 16459611
SGTC_2878 9043973 25.97 µM -1.19997667257733 0.205053124408354 no 2679 0.115074200145291 1001 6465167
SGTC_2088 5278280 127.392 µM -1.20310644017567 0.204446769377766 no 2680 0.11446756676449 975 791502
SGTC_2141 5621638 7.665 µM -1.2045065504474 0.204175860623456 no 2681 0.114196925893582 978 2856238
SGTC_1550 gossypolone 36.6 µM -1.20521551787878 0.204038763374868 no 2682 0.11406005665462 980 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1072 oxiconazole 14.9 nM -1.21082566000801 0.202955832232734 no 2683 0.112981114309013 959 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3118 9124250 49.47 µM -1.21141278345192 0.202842697988496 no 2684 0.112868621231911 951 1504786
SGTC_3084 9116877 49.47 µM -1.21221945024969 0.202687320855406 no 2685 0.112714193995761 960 27241325
SGTC_1137 ixabepilone 100 µM -1.21570219997709 0.202017303541651 no 2686 0.112049192908215 975 154225 A novel microtubule stabilizer.
SGTC_2281 7943571 200 µM -1.21851983104519 0.201476214164745 no 2687 0.111513246710782 987 1244024
SGTC_2646 retinol 96.75 µM -1.22019608318623 0.201154724176191 no 2688 0.111195275666832 955 445354 A vitamin A analog and teratogen.
SGTC_1119 parthenolide 318.541 nM -1.22035338325436 0.201124571243544 no 2689 0.111165470507865 999 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3165 9101544 49.47 µM -1.22121508776814 0.200959438755948 no 2690 0.111002296554945 986 5002184
SGTC_2449 5812982 45.77 µM -1.22170095276616 0.200866366034094 no 2691 0.110910367933004 989 776185
SGTC_3062 9077494 49.47 µM -1.22329477886523 0.200561232968799 no 2692 0.110609189238098 865 16459633
SGTC_3200 9114385 49.47 µM -1.22754253250166 0.199749374218813 no 2693 0.109809373023806 960 17018030 YLR208W SEC13
SGTC_1445 4239-0156 97.7 µM -1.22808987298579 0.199644906863219 no 2694 0.109706616101105 1005 4008346
SGTC_2267 7931562 200 µM -1.22954081924161 0.199368133220683 no 2695 0.109434551607537 985 934880
SGTC_1909 st060837 51.5 µM -1.23063129425207 0.199160273010299 no 2696 0.109230397669311 967 678937
SGTC_1888 azatryptophan 97.5 µM -1.23076143938579 0.199135474199898 no 2697 0.109206050759496 973 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_766 1391-0721 126 µM -1.23591955115059 0.198154108169255 no 2698 0.108244234426568 1007 1020919 YIL115C NUP159
SGTC_2248 tofa 1.1 µM -1.23813180385953 0.197734108205931 no 2699 0.107833596482255 944 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2129 girgensonine 121.053 µM -1.23819673836031 0.197721788412202 no 2700 0.107821560325683 986 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1793 st048256 72.231 µM -1.23984746411828 0.197408757841741 no 2701 0.107515909313704 975 672022
SGTC_340 k038-0059 454 µM -1.24128771203933 0.197135885588139 no 2702 0.107249741207272 973 23733424
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.24326709133379 0.196761241024562 no 2703 0.106884713386853 964 6708514
SGTC_3300 9124615 50.48 µM -1.24680423569466 0.196092827069787 no 2704 0.106234643513401 983 24824903
SGTC_2048 5246248 200 µM -1.24691118185108 0.196072638933668 no 2705 0.106215033116281 963 677046
SGTC_497 capsazepine 133 µM -1.24807736454052 0.195852581437836 no 2706 0.106001363376135 986 2733484 A calcium channel blocker.
SGTC_592 k241-0073 46.5 µM -1.24824330428984 0.195821280959486 no 2707 0.105970984906439 993 4230158
SGTC_2981 9013952 38.96 µM -1.25180906684816 0.195149420718806 no 2708 0.105319722760003 978 2996344
SGTC_602 3130-1533 38.1 µM -1.25475477166397 0.194595449769457 no 2709 0.104783897938406 993 720941
SGTC_2622 2-methoxyxanthone 59.94 µM -1.25479354380845 0.194588164644025 no 2710 0.104776858457473 990 71034 A hepatoprotective.
SGTC_2388 9080168 200 µM -1.25709956661433 0.194155171042043 no 2711 0.104358792041187 977 15943073
SGTC_629 3448-6466 76.7 µM -1.26061064131076 0.193497037282645 no 2712 0.103724581405843 996 573744
SGTC_764 1951-2361 146 µM -1.26465310537365 0.192740984839566 no 2713 0.102997853636953 972 5438930
SGTC_1746 st038117 42 µM -1.26511595361461 0.192654534746444 no 2714 0.102914882378617 986 2898218
SGTC_3252 9135871 49.47 µM -1.26628375437549 0.192436520032373 no 2715 0.102705755528083 992 17682838
SGTC_1277 0873-0036 22 µM -1.27077481173685 0.191599498706179 no 2716 0.10190438601671 984 5965735
SGTC_1274 0865-0114 173 µM -1.27090245181272 0.191575742409552 no 2717 0.101881677036527 992 870624
SGTC_3149 9097855 49.47 µM -1.27505584983346 0.19080369929332 no 2718 0.101144737365065 979 25236625 YMR079W SEC14
SGTC_479 n-linoleoylglycine 10 µM -1.27507052471679 0.190800974881435 no 2719 0.101142140497811 1003 6433346 An anti-infammatory.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.27563019818268 0.190697088562832 no 2720 0.101043136946653 999 115019
SGTC_1805 st050013 60.3 µM -1.27574057986531 0.190676603667469 no 2721 0.101023619299019 972 4037144
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.27597903641733 0.190632354943647 no 2722 0.10098146488228 986 16725076
SGTC_2205 7238770 200 µM -1.27669120486545 0.190500240325172 no 2723 0.100855643880281 987 279867
SGTC_986 1493-0483 84 µM -1.27733634397441 0.190380608885895 no 2724 0.100741763869844 994 40079
SGTC_862 0452-0056 10.2 µM -1.27778776914055 0.190296926257136 no 2725 0.100662134046954 1005 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1791 st048313 56.1 µM -1.28148407434039 0.189612576477505 no 2726 0.100011845106005 956 1204976
SGTC_21 0849-0113 22.993 µM -1.2816569608607 0.189580604633801 no 2727 0.09998150454698 1000 1560156
SGTC_617 3770-0098 35 µM -1.28296705954244 0.189338436351083 no 2728 0.0997518084287946 981 5962639
SGTC_290 2043-6722 48.1 µM -1.28303157145443 0.18932651641564 no 2729 0.0997405076941786 989 773758 YLR208W SEC13
SGTC_298 1391-0729 10 µM -1.28628157975701 0.18872660684082 no 2730 0.0991724043623829 990 3237558
SGTC_3339 9145883 14.936 µM -1.29095696480463 0.187865648917559 no 2731 0.098359300335728 951 2030670
SGTC_2334 9017922 200 µM -1.29198005313301 0.187677574249234 no 2732 0.0981820262315619 978 3163164
SGTC_2168 5727979 200 µM -1.29336255953536 0.187423612496729 no 2733 0.0979428464886895 1000 695210
SGTC_2551 apiole 73.87 µM -1.2943854583536 0.187235846232282 no 2734 0.0977661555009538 978 10659 A possible DNA adduct former.
SGTC_2832 7992762 51.95 µM -1.29702418277561 0.186752011654063 no 2735 0.0973114331210747 983 2985177
SGTC_344 k064-0035 6.43 µM -1.29932052016102 0.186331587318479 no 2736 0.0969169775228955 964 5088750
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.30293957367351 0.185670185267413 no 2737 0.0962976960102671 996 688664
SGTC_665 3914-0008 307 µM -1.31035763346261 0.184319053444122 no 2738 0.0950374394228977 995 1069549
SGTC_843 0310-0051 143 µM -1.31063457857497 0.184268729171934 no 2739 0.0949906254940599 1006 2065037
SGTC_1530 rhein 70.4 µM -1.31235960947037 0.183955462746254 no 2740 0.0946994140888105 990 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2056 5235370 200 µM -1.31380860408158 0.183692581077091 no 2741 0.0944553107103553 1000 5511916
SGTC_3161 9100388 49.47 µM -1.3172375506586 0.183071422502034 no 2742 0.0938795053349024 1009 25236368
SGTC_484 loperamide 105 µM -1.31852226146541 0.182839033155524 no 2743 0.0936644389574106 989 3955 An opioid-receptor agonist.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.32243241216052 0.182132865771456 no 2744 0.093012100890413 1011 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1875 nocodazole 6 µM -1.32494511304494 0.181679976802131 no 2745 0.0925946782654388 1001 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2257 7960413 200 µM -1.3252218568082 0.181630139645713 no 2746 0.0925487890384287 970 2974689 YIL048W NEO1
SGTC_988 1497-1057 103 µM -1.32692085171204 0.181324365156328 no 2747 0.0922674329566992 1000 3533044
SGTC_1061 3448-9325 110 µM -1.32783382321493 0.181160187471317 no 2748 0.0921165052644639 990 723482
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.3293838161649 0.180881668915048 no 2749 0.0918606871997754 970 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_704 1310-0270 142 µM -1.33136033161824 0.180526897986055 no 2750 0.0915352376795383 994 5718033
SGTC_2743 auranofin 4.32 µM -1.33206059835194 0.180401309700791 no 2751 0.0914201382439656 978 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1567 st069303 68.4 µM -1.33564722551074 0.179758931106883 no 2752 0.0908323032505804 997 5581319
SGTC_2264 7948757 110.76 µM -1.33687709308115 0.179538988411063 no 2753 0.0906313795949135 1005 2971411
SGTC_1079 idarubicin 2.36 µM -1.34101337516629 0.178800520382356 no 2754 0.0899580550306892 992 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1999 st074831 12.5 µM -1.34209127358955 0.178608393095389 no 2755 0.0897832014912554 991 17112523
SGTC_3012 9080433 71.4286 µM -1.34424557173471 0.178224795402266 no 2756 0.0894344947872322 993 17688859
SGTC_2311 7694451 200 µM -1.34430804222789 0.178213679560945 no 2757 0.089424398015562 1008 2163142
SGTC_3345 9148410 3.559 µM -1.34548678856165 0.178004018337814 no 2758 0.08923404245241 967 4903596
SGTC_573 3702-0553 84.7 µM -1.34746866786803 0.177651856223454 no 2759 0.0889146689468323 991 1222756
SGTC_1765 st044815 90.4 µM -1.34896278620984 0.177386655697989 no 2760 0.0886744597268599 1005 645695
SGTC_1145 3546-0597 10.2 µM -1.34967930217692 0.177259565461767 no 2761 0.0885594371561609 998 875334
SGTC_3129 9127257 49.47 µM -1.34997163638233 0.177207729930199 no 2762 0.0885125405758738 1001 837894
SGTC_1649 st011737 51.3 µM -1.35602452309358 0.176136608226432 no 2763 0.0875456827946735 941 1761035
SGTC_908 3448-7491 47.7 µM -1.35604326085116 0.176133298759825 no 2764 0.0875427020054114 948 1203031
SGTC_3048 9093155 49.47 µM -1.35683308546452 0.175993835571865 no 2765 0.087417126132336 980 25236002
SGTC_2676 harmalol 100 µM -1.35720825145532 0.17592761518199 no 2766 0.0873575248258582 992 5459187 A monoamine oxidase inhibitor
SGTC_1825 st052143 62.6 µM -1.36004342496672 0.175427690201457 no 2767 0.0869080912437173 1004 674173
SGTC_864 0469-0573 172 µM -1.36552833297427 0.174463097833906 no 2768 0.0860435271290476 1026 689425
SGTC_315 k915-0449 187 µM -1.3657640683359 0.174421716353655 no 2769 0.0860065138580868 996 20970215 YNL149C PGA2
SGTC_1395 3486-0190 4.35 µM -1.36826437132664 0.173983191753624 no 2770 0.0856146694063372 1011 6748079
SGTC_3294 9122953 26.2835 µM -1.37634950068903 0.172569955899735 no 2771 0.084356727217588 1016 16459826
SGTC_332 4112-0506 40.9 µM -1.37796336910076 0.172288739468823 no 2772 0.0841072990527576 1015 2790355
SGTC_425 3825-7017 13.1 µM -1.37828886584902 0.172232057140042 no 2773 0.0840570597248437 997 3397440
SGTC_885 0865-0106 16.8 µM -1.37918877232834 0.172075408461966 no 2774 0.0839182794428225 1006 2793380
SGTC_2402 5553605 200 µM -1.38121946929959 0.171722254893087 no 2775 0.0836057451302323 1020 6758546
SGTC_2971 9092186 9.93 µM -1.3823060106398 0.171533487395534 no 2776 0.0834388806104003 1000 25236400
SGTC_634 1611-4317 11.2 µM -1.38276243001378 0.171454232099433 no 2777 0.0833688611572094 1019 2843522
SGTC_1050 3232-1156 69.3 µM -1.38319896909877 0.171378450831894 no 2778 0.0833019328784717 1009 700529
SGTC_1924 st058459 75.1 µM -1.38510767758243 0.171047358933135 no 2779 0.0830097723225136 989 688683
SGTC_1874 staurosporine 7.6 µM -1.38548283573363 0.170982330704123 no 2780 0.0829524386747891 989 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1372 2752-0194 270 µM -1.3856394601591 0.170955186809932 no 2781 0.0829285113197816 998 823334
SGTC_57 miconazole 162.5 nM -1.38847442429053 0.17046434818342 no 2782 0.0824963137333235 976 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2310 7668677 200 µM -1.38862862551729 0.170437676072062 no 2783 0.0824728540764805 1009 2197143
SGTC_1206 3978-0017 132 µM -1.3894100623671 0.170302552413706 no 2784 0.0823540461101033 989 3873677
SGTC_69 0096-0274 206.684 µM -1.39002788097592 0.170195769709379 no 2785 0.0822602055688059 1018 6741392
SGTC_2735 sertaconazole 140 nM -1.39324078625493 0.169641148552319 no 2786 0.0817734949723985 1051 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2989 9073649 71.4286 µM -1.39334294957686 0.169623531859052 no 2787 0.0817580543310675 1003 21367202
SGTC_2885 9057732 51.95 µM -1.39622003545652 0.169127898962054 no 2788 0.0813241225651017 1001 6471414
SGTC_3242 9133940 49.47 µM -1.39945590466474 0.168571571106722 no 2789 0.0808381562809374 1013 17248444
SGTC_951 1171-0579 82.7 µM -1.40128041285068 0.168258411202516 no 2790 0.0805651180425837 991 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2297 7971671 152.32 µM -1.40481902249124 0.167652109187523 no 2791 0.0800375505057478 1009 909016
SGTC_1972 st070201 17.4 µM -1.4058434034626 0.16747685567808 no 2792 0.07988531520135 1020 2829099
SGTC_2937 9044753 11.33 µM -1.4095235510058 0.166848221479856 no 2793 0.0793402073004946 978 6465530 YGL099W LSG1
SGTC_1035 k081-0041 55.2 µM -1.40989939989371 0.166784105629221 no 2794 0.0792846949560003 999 731709
SGTC_383 2324-0395 7.37 µM -1.41009186611253 0.166751279080184 no 2795 0.0792562793563593 931 3146421
SGTC_365 0121-0052 13.6 µM -1.41232028372695 0.166371509421697 no 2796 0.0789278382958941 973 3101739
SGTC_275 trichlorophene 5.69 µM -1.41677530762567 0.165613954522386 no 2797 0.0782743155976698 981 62616
SGTC_2978 9011784 42.97 µM -1.42859987220331 0.163614081927156 no 2798 0.076559635459459 979 2994934
SGTC_2624 nerol 100 µM -1.43406287369821 0.162695449638574 no 2799 0.0757771607017938 1013 637566 A natural product oil.
SGTC_983 1491-0821 12.2 µM -1.43583498070987 0.16239818263404 no 2800 0.0755246516963513 1007 46495113
SGTC_1311 1190-0148 100 µM -1.4369398823528 0.162213016876908 no 2801 0.0753675381619247 1009 1961333
SGTC_1553 gossypol 38.6 µM -1.43997580595068 0.161704947428685 no 2802 0.0749371220833212 994 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_720 r052-1644 49.9 µM -1.44068115424832 0.161587054252402 no 2803 0.074837390726048 1019 1422863 YOR257W CDC31
SGTC_63 0099-0242 26.702 µM -1.44826107342954 0.160323670490182 no 2804 0.0737720249350138 1010 3898502 YLR359W ADE13
SGTC_1720 st037298 9.481 µM -1.45272087935923 0.159583356582053 no 2805 0.0731506337097727 1018 597396
SGTC_2973 9094665 17.96 µM -1.45310865433566 0.159519093035526 no 2806 0.0730967942835804 997 25237061 YIL048W NEO1
SGTC_2771 fluoxetine 41.05 µM -1.45392001599143 0.159384685899456 no 2807 0.0729842413728334 1011 3386 A selective serotonin reuptake inhibitor.
SGTC_2186 6124449 200 µM -1.45712402386606 0.158854646694414 no 2808 0.0725410739909355 1012 3834182 YLR033W RSC58
SGTC_1438 4092-1045 4 µM -1.45845597787604 0.158634641820395 no 2809 0.0723574503872859 1012 1351342
SGTC_938 3126-1755 342 µM -1.46367812354155 0.1577740044976 no 2810 0.0716409577750771 999 1777771
SGTC_1229 0139-0193 12.2 µM -1.46568662433019 0.157443811028449 no 2811 0.0713668398828382 1005 3090752
SGTC_615 k087-0205 167 µM -1.46678991558601 0.157262625579497 no 2812 0.0712166069109354 1020 9642773
SGTC_73 0327-0325 16.231 µM -1.47538490836837 0.155855828379444 no 2813 0.0700545452027084 950 53298
SGTC_1196 1588-0294 184 µM -1.47785650670678 0.155452826839932 no 2814 0.0697230949499747 1027 6144269
SGTC_3064 1327-0027 10 µM -1.47807211934312 0.15541770318592 no 2815 0.0696942378615732 995 16000455 YPR107C YTH1
SGTC_1298 1079-1278 263 µM -1.47884885560292 0.155291214982426 no 2816 0.0695903575227087 1021 2840950
SGTC_3085 9117376 49.47 µM -1.48142043278949 0.154872929514052 no 2817 0.0692472866014311 1011 16480349
SGTC_448 monastrol 171 µM -1.48330239382699 0.154567287101829 no 2818 0.0689970433173774 1027 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_604 1000-0114 314 µM -1.48441424533626 0.154386902828207 no 2819 0.0688495289313418 1039 1572745
SGTC_962 1254-0300 21.5 µM -1.48608648139715 0.154115865221557 no 2820 0.0686281237871603 1006 7340576
SGTC_3278 9139605 49.47 µM -1.48614636779378 0.154106164619178 no 2821 0.0686202049859558 1017 7958859
SGTC_2208 7283366 200 µM -1.48979353004049 0.153516146217866 no 2822 0.0681392664236899 1009 898663
SGTC_1059 3448-6867 171 µM -1.48987635511592 0.153502764616485 no 2823 0.0681283748629214 1019 3934407
SGTC_2260 7964312 200 µM -1.49067310447992 0.153374077573291 no 2824 0.0680236703448998 1028 231951
SGTC_924 2046-0044 21.3 µM -1.4967032627511 0.152402433917222 no 2825 0.067235243461174 1010 3623589
SGTC_444 curcumin 90.4 µM -1.50098224040752 0.151715442634961 no 2826 0.0666800775458983 999 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_304 1310-0298 97 µM -1.50522158489517 0.151036847112107 no 2827 0.0661335587696981 1027 1550234
SGTC_2912 7964298 10.93 µM -1.50739789702773 0.150689268746465 no 2828 0.0658543487547713 995 2975850
SGTC_111 0083-0039 52.457 µM -1.50764374544625 0.150650037855776 no 2829 0.0658228651439865 1022 759313
SGTC_2732 terfenadine 20 µM -1.5121902053572 0.14992576932888 no 2830 0.0652427410125607 1047 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1251 0490-5699 265 µM -1.51263290732998 0.149855369472599 no 2831 0.065186465251233 1026 3883818
SGTC_1651 st011928 86.1 µM -1.5286178578123 0.147328161489901 no 2832 0.0631796031756691 1031 720198
SGTC_649 1123-0311 367 µM -1.53220844893283 0.146764443518327 no 2833 0.0627355021360598 1016 693629 YIL048W NEO1
SGTC_1247 0448-0043 5.84 µM -1.53243250727593 0.146729314692604 no 2834 0.0627078704012544 1030 3089013 YGL099W LSG1
SGTC_2619 obliquin 87.91 µM -1.53350836888387 0.14656071509231 no 2835 0.0625753231142 1004 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2553 4-methylesculetin 85.09 µM -1.53495295714766 0.146334536464564 no 2836 0.062397691940591 1020 5319502
SGTC_2393 9031399 185.94 µM -1.53744767419307 0.14594449170082 no 2837 0.0620918597032545 1032 1526623 YDL150W RPC53
SGTC_525 k781-2675 26.7 µM -1.5391682058692 0.145675896903224 no 2838 0.061881618677928 990 3651118 YDL195W SEC31
SGTC_102 gallobenzophenone 83.616 µM -1.53955221223406 0.145615994482312 no 2839 0.0618347708017055 1004 70837
SGTC_1657 st012939 43.4 µM -1.54182558679102 0.14526170256478 no 2840 0.0615579912863909 1021 24207257
SGTC_727 3032-0951 202 µM -1.54681725253688 0.144485817416016 no 2841 0.0609536593981589 1034 3652836
SGTC_3087 9117406 49.47 µM -1.54710511525181 0.144441158473568 no 2842 0.060918950339769 1015 42546093
SGTC_138 0850-0259 40.9225 µM -1.54803332300062 0.14429721993732 no 2843 0.0608071368908571 1015 6813004
SGTC_333 3486-0131 40.1 µM -1.54890143132014 0.14416268863317 no 2844 0.060702708414472 1005 6744690
SGTC_1747 st037496 66.6 µM -1.54950487787229 0.144069221971682 no 2845 0.0606301999175138 1028 723305
SGTC_1883 5-benzylidenerhodanine 20 µM -1.54981922274111 0.144020549898204 no 2846 0.0605924559399195 1003 1273210
SGTC_2025 5147754 141 µM -1.55073064895611 0.143879490507556 no 2847 0.0604831231916109 974 315777 YLR208W SEC13
SGTC_1164 k060-0068 93.7 µM -1.55134022745832 0.143785199439166 no 2848 0.06041008563656 1027 5963676
SGTC_570 0987-0065 62.6 µM -1.55197954272866 0.143686353418133 no 2849 0.0603335592958344 995 3104428
SGTC_514 4466-0038 2.65 nM -1.55224209779101 0.143645772455532 no 2850 0.0603021533167014 974 5722064
SGTC_2020 4017018 200 µM -1.55382649489448 0.143401049493916 no 2851 0.0601129044149267 1034 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_714 4296-0578 26.1 µM -1.55461314058369 0.143279650337075 no 2852 0.060019116142093 1034 1589775
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.55828261098621 0.142714276225695 no 2853 0.0595831346051363 1040 16623 A steroid.
SGTC_337 1315-0038 354 µM -1.55880728725602 0.142633560079874 no 2854 0.0595209994615932 1029 1626437
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.56115557434008 0.142272678122356 no 2855 0.0592435240825946 1013 17037758
SGTC_2962 9082311 13.18 µM -1.56799918096177 0.141224487052191 no 2856 0.0584406617463059 1031 16459453
SGTC_2435 5706476 10.6 µM -1.57118721737038 0.140737988111615 no 2857 0.0580695841699112 1009 5725375
SGTC_362 0310-0100 9.03 µM -1.57237036328469 0.140557728028637 no 2858 0.0579323416651633 1033 790235
SGTC_79 0052-0007 94.094 µM -1.57273988641082 0.14050146087549 no 2859 0.0578895300267611 1000 2801472
SGTC_3049 9092223 49.47 µM -1.57742612541098 0.139789215544103 no 2860 0.0573487539944 1031 8623917
SGTC_597 k018-0003 82.8 µM -1.57762755692936 0.139758655776878 no 2861 0.0573255988849566 1041 6786234
SGTC_1733 st037357 54.9 µM -1.57829365839818 0.13965763191035 no 2862 0.0572490810638613 1024 1272339 YGL099W LSG1
SGTC_1942 st076330 65.2 µM -1.58092748420086 0.139258660756922 no 2863 0.0569473096368944 1031 24208414
SGTC_58 0957-0393 9 µM -1.58346727790887 0.138874668760423 no 2864 0.0566574995794842 1024 6997992
SGTC_1070 indatraline 8.81 µM -1.58703582897584 0.138336357941769 no 2865 0.0562522650621909 1026 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2873 9040596 71.43 µM -1.58968975163577 0.137936940890174 no 2866 0.0559523774404059 1039 6463863
SGTC_3261 9137475 49.47 µM -1.60104309676122 0.136237141234763 no 2867 0.054683687053424 1003 17027690
SGTC_122 0236-0016 402.397 µM -1.60480549915184 0.135677017514688 no 2868 0.0542683077005614 1012 6808838
SGTC_2029 5175081 200 µM -1.6054867527308 0.135575765518617 no 2869 0.0541933631095523 1034 1380876
SGTC_863 0466-0191 129 µM -1.60783739800552 0.135226796065927 no 2870 0.0539353977080844 1040 765160 YPR165W RHO1
SGTC_1706 st031321 9.9705 µM -1.60994672802241 0.134914176181145 no 2871 0.0537047432877322 1032 6103185
SGTC_2839 9003951 25.97 µM -1.61311844641477 0.134445035515929 no 2872 0.0533593884871804 1016 2990634
SGTC_1499 4480-0877 67.3 µM -1.62413460399212 0.132824301791286 no 2873 0.0521735420534509 1025 2861909
SGTC_2545 solidagenone 89.61 µM -1.62518974772415 0.132669774593687 no 2874 0.0520610671377158 1014 6708572 An anti ulcer agent
SGTC_1263 0774-1208 64.8 µM -1.63861695093328 0.130714154614124 no 2875 0.0506465299120839 1035 906585
SGTC_975 1335-0046 28.5 µM -1.64482586654153 0.129816621602955 no 2876 0.0500028631530239 1032 16486740
SGTC_2287 7945887 168.79 µM -1.645525601764 0.129715739221517 no 2877 0.0499307337396663 1033 1245853
SGTC_27 0485-0001 32.618 µM -1.65195696687274 0.12879105766264 no 2878 0.0492716618518896 1014 2054479
SGTC_821 1114-0266 29.2 µM -1.65355435590982 0.128562100739686 no 2879 0.0491090466417146 1033 3123235
SGTC_124 0136-0217 7.121 µM -1.65425262829361 0.128462104764374 no 2880 0.0490380968560443 1026 3976905
SGTC_706 4262-0057 46.9 µM -1.65655239156886 0.128133149337177 no 2881 0.0488050022074567 1055 883298
SGTC_2078 5212016 200 µM -1.65821832909472 0.127895221316365 no 2882 0.0486367032553176 1033 1899708
SGTC_2256 7954252 200 µM -1.65919105499327 0.127756439333091 no 2883 0.048538649755808 1055 2972920
SGTC_2586 curcumin 80 µM -1.65923475868373 0.127750206442669 no 2884 0.0485342480142107 1051 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2921 7974240 10.71 µM -1.65964077425053 0.127692311811821 no 2885 0.0484933702550561 1036 2979074 YDR527W RBA50
SGTC_462 ag-879 158 µM -1.65989067439454 0.127656687082603 no 2886 0.0484682239302306 1035 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1136 pergolide 1.05886 µM -1.66068809994265 0.127543055601694 no 2887 0.0483880523121905 1030 47811 A dopamine receptor agonist.
SGTC_2778 tioconazole 65.09 nM -1.66270461028293 0.12725602092437 no 2888 0.0481857894561449 1003 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_898 1000-0849 28.3 µM -1.66648084120739 0.126719713033284 no 2889 0.047808840520554 1044 6751807
SGTC_1317 1273-0028 910 nM -1.66715792032905 0.126623719542267 no 2890 0.0477415037662594 1025 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2163 5671233 125 µM -1.66990855972602 0.126234266064987 no 2891 0.0474687282657857 1018 701023
SGTC_1479 0549-0158 134 µM -1.67032097494843 0.126175945673488 no 2892 0.0474279377142471 1043 5440202
SGTC_2475 5812728 15.03 µM -1.67648907172384 0.125305944273263 no 2893 0.0468212175079672 1041 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_504 lovastatin 124 µM -1.68236458014018 0.124481114949671 no 2894 0.0462490826508706 1050 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2229 7354935 190 µM -1.68376568576267 0.12428498351332 no 2895 0.0461134806094514 1046 318112
SGTC_1406 3909-7906 11.9 µM -1.6837740386788 0.124283814892754 no 2896 0.0461126731547257 1005 X1406
SGTC_2666 tannic acid 100 µM -1.68394781725916 0.124259504022266 no 2897 0.0460958770059775 1025 16134267 A thiamine antagonist.
SGTC_1444 4112-3581 28 µM -1.68822932139977 0.123661590428649 no 2898 0.0456836083542488 1045 2877249
SGTC_2041 5107442 45.335 µM -1.68842329771611 0.123634549351229 no 2899 0.0456650006690744 1046 793005
SGTC_2511 berberine 10.47 µM -1.68922846830792 0.123522349603276 no 2900 0.0455878276998973 1032 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1249 0481-0015 10.2 µM -1.69050208411317 0.123345018122709 no 2901 0.0454659699364417 1027 4227577
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.69270396515907 0.123038860826736 no 2902 0.0452559150750646 1023 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2849 9019321 12.99 µM -1.69372445163829 0.122897149597481 no 2903 0.0451588279178524 1034 16489627
SGTC_2103 5378138 10 µM -1.69553467791746 0.122646051736697 no 2904 0.0449870187839537 1038 244142
SGTC_1707 st032323 6.317 µM -1.70039297158606 0.121973933908111 no 2905 0.0445285164867738 1023 3132057 YMR211W DML1
SGTC_558 k064-0027 21.3 µM -1.70399008747628 0.121477962663488 no 2906 0.0441914695665105 1043 5088526
SGTC_1293 1000-1278 195 µM -1.70576994016501 0.121233081118323 no 2907 0.0440254609541967 1048 678847
SGTC_669 0108-0021 26.2 µM -1.70599563492339 0.121202053660584 no 2908 0.0440044461555263 1040 17201
SGTC_1711 st032263 62.8 µM -1.70680434777307 0.121090921470258 no 2909 0.043929212027139 1044 3958979
SGTC_989 1501-0895 10.3 µM -1.71183401313709 0.120401361094928 no 2910 0.0434636309773436 1032 2830112
SGTC_2782 7736369 71.43 µM -1.72437227238665 0.118694437307784 no 2911 0.0423203299030057 1034 2950836 YOL077C BRX1
SGTC_991 3996-0057 64.7 µM -1.72590665682655 0.118486730502769 no 2912 0.042182103472993 1043 715343
SGTC_2734 clemastine 41.6 µM -1.73122835426756 0.117768333081721 no 2913 0.0417055220425755 1077 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1922 5578187 25 µM -1.73331975377566 0.117486852052698 no 2914 0.0415194258183887 1018 1350412
SGTC_884 0851-0618 334 µM -1.7336636837007 0.117440608241441 no 2915 0.0414888868769555 1037 9642473
SGTC_410 α-linolenic acid 100 µM -1.73714530300691 0.116973205423426 no 2916 0.0411807633119974 1049 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2375 9072683 200 µM -1.73863506259134 0.11677361041868 no 2917 0.041049487500249 1049 16798029
SGTC_1921 5740136 50 µM -1.73866451992585 0.116769666219776 no 2918 0.0410468951812359 1035 1774243
SGTC_928 2764-0428 58.7 µM -1.74715103510463 0.115637292038275 no 2919 0.0403055713459994 1049 662578
SGTC_3181 9108277 49.47 µM -1.75161309602335 0.115045048392836 no 2920 0.0399201795772629 1047 17097298
SGTC_501 nsc-95397 161 µM -1.75192437956206 0.115003812760326 no 2921 0.0398934059106157 1038 262093
SGTC_460 trequinsin 123 µM -1.75915190393302 0.114049338773834 no 2922 0.0392758554637746 1077 5537 A vasodilator.
SGTC_2277 7947813 106.88 µM -1.76102154207714 0.113803353860799 no 2923 0.0391173784876995 1053 1246798
SGTC_539 4859-0462 2.54 µM -1.76723461040627 0.112988628442482 no 2924 0.0385944728215755 1028 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2757 clomiphene 4.22 µM -1.77181335296723 0.112390883921575 no 2925 0.0382127726317721 1055 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2661 dactinomycin 12.96 µM -1.77543117926538 0.11192018529266 no 2926 0.0379133598028304 1049 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_792 4534-1957 155 µM -1.77642448638017 0.111791197702271 no 2927 0.037831489066469 1047 1717904
SGTC_2122 5258151 111.688 µM -1.77660879880987 0.111767275196972 no 2928 0.0378163134784672 1058 2173356
SGTC_310 1273-0058 1.06 µM -1.78022940977297 0.111298086673944 no 2929 0.0375192120894326 975 2734232
SGTC_1755 st041960 45.185 µM -1.78202494487372 0.111065930193554 no 2930 0.0373725819862796 1055 2257073
SGTC_2696 st077691 74.316 µM -1.78239311249535 0.111018370270037 no 2931 0.0373425739477682 1046 757133
SGTC_2899 9053889 58.44 µM -1.78378085910996 0.11083923216411 no 2932 0.0372296405084828 1040 6470052
SGTC_2196 6573537 42.6665 µM -1.79083656130969 0.109931645538425 no 2933 0.0366597631383901 1069 2903087
SGTC_623 k072-0108 16.9 µM -1.79771332140754 0.109052220284519 no 2934 0.0361112246424082 1046 5382803
SGTC_1472 k841-0093 193 µM -1.80229728978211 0.108468821178012 no 2935 0.035749322360033 1057 X1472
SGTC_2404 5161160 200 µM -1.80800319343894 0.107745775427956 no 2936 0.0353030017812347 1034 2831543
SGTC_1423 4048-0112 5.59 µM -1.80893132002652 0.107628493344378 no 2937 0.0352308369538791 1059 X1423
SGTC_245 methotrexate 289.6 µM -1.80981159062243 0.107517343568606 no 2938 0.035162504941168 1044 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2227 7312221 64.1025 µM -1.81196015722521 0.107246396348036 no 2939 0.0349961765185308 1077 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1348 1493-0373 93.8 µM -1.82167194466324 0.106027822878126 no 2940 0.0342523886629056 1059 3010129
SGTC_3066 9117245 49.47 µM -1.82925505822459 0.105083320968852 no 2941 0.0336807039079337 1046 17176980
SGTC_961 1252-1571 372 µM -1.82986534892385 0.105007572848174 no 2942 0.0336350380177473 1051 6813498
SGTC_1320 1313-0481 95.3 µM -1.82999975624504 0.104990895779274 no 2943 0.0336249876442796 1051 6813365 YLR208W SEC13
SGTC_916 4466-0038 42 nM -1.84011812821327 0.103740922138669 no 2944 0.0328754481858957 1055 5722064 YGL116W CDC20
SGTC_191 3914-0123 66.505 µM -1.84141706288727 0.103581243403393 no 2945 0.0327802321196874 1066 3144412
SGTC_2374 9071832 200 µM -1.84188971116094 0.103523184777126 no 2946 0.0327456419546395 1055 17381698
SGTC_3038 9091290 49.47 µM -1.84708384565722 0.102886708988623 no 2947 0.0323674946873836 1053 25236843
SGTC_2054 5233173 129 µM -1.84864025328504 0.102696545584683 no 2948 0.0322548880933458 934 6889
SGTC_3168 9103419 49.47 µM -1.85190408037291 0.102298597787441 no 2949 0.0320197989593182 1065 16649256
SGTC_2947 9072639 7.68 µM -1.85320143104937 0.102140727948282 no 2950 0.0319267463240353 1062 16488146
SGTC_483 fpl-64176 144 µM -1.85438215327419 0.101997204320911 no 2951 0.0318422531129328 1068 3423
SGTC_459 nigericin 15.3 µM -1.85953896840583 0.101372083631497 no 2952 0.0314753905233308 1061 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_788 1182-0090 188 µM -1.86012179275683 0.101301608284745 no 2953 0.0314341482890349 1057 5715185
SGTC_373 0844-0104 25.9 µM -1.86051329369378 0.101254287886641 no 2954 0.0314064697123148 1048 5375804
SGTC_1426 4048-4480 71.7 µM -1.86538442303126 0.100666864839267 no 2955 0.0310637695950955 1058 14224343
SGTC_2160 5660466 132.927 µM -1.86575859265654 0.100621845696748 no 2956 0.03103757397581 1053 2859134
SGTC_2446 5162541 200 µM -1.86635252969648 0.100550414855385 no 2957 0.0309960299742137 1065 1549321
SGTC_2396 5342950 42.78 µM -1.86687328193549 0.100487816150584 no 2958 0.0309596428855561 1019 1886677
SGTC_3251 9135047 49.47 µM -1.87022053228625 0.100086127777537 no 2959 0.0307265997995777 1063 17682963
SGTC_996 3970-0799 1.8 µM -1.87257746612329 0.0998039870407992 no 2960 0.0305633777125516 1042 6615648 YGL040C HEM2
SGTC_2215 7188065 200 µM -1.87753565430613 0.0992123563051721 no 2961 0.0302223577014736 1060 940217
SGTC_1405 3909-7894 12 µM -1.88082253617979 0.0988215685862797 no 2962 0.0299980317340327 1020 7104060
SGTC_1792 st045773 43.6 µM -1.88679874811973 0.0981139258494664 no 2963 0.0295936997903922 1050 2919270
SGTC_2246 7293507 91.5585 µM -1.88792041782534 0.0979815238611206 no 2964 0.0295183175155199 1059 887656
SGTC_1143 3454-2408 5.08 µM -1.89042464005155 0.0976863978247191 no 2965 0.0293505952897804 1013 X1143
SGTC_88 0180-0332 8.668 µM -1.89217043620267 0.0974810392554498 no 2966 0.0292341380013533 1053 3101745
SGTC_1301 naphtanilide LB 4.81 µM -1.89322219487787 0.0973574734808423 no 2967 0.0291641635016892 1045 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2799 7812892 81.82 µM -1.8948146322033 0.0971706048771403 no 2968 0.0290584819973103 1036 20205235
SGTC_3030 9087619 49.47 µM -1.89496167495742 0.0971533630552564 no 2969 0.0290487396284192 1050 25236973
SGTC_1495 4469-0029 237 µM -1.89678218465884 0.0969400811288721 no 2970 0.0289283457805028 1054 793680
SGTC_1563 conessine 56.1 µM -1.89773548155288 0.0968285347937319 no 2971 0.0288654680272537 1064 441082 An anti-amoebic, histamine inhibitor.
SGTC_10 0279-0212 42.575 µM -1.89920252798197 0.096657058220016 no 2972 0.0287689262493847 1072 39851 YBR002C RER2
SGTC_1440 4100-1550 40 µM -1.90207554104317 0.0963218907442597 no 2973 0.0285806397754273 1070 742806
SGTC_2044 5102272 200 µM -1.90684033282041 0.0957679114914397 no 2974 0.0282706333415213 1064 592666
SGTC_3266 9136860 49.47 µM -1.91500534740416 0.0948240604232012 no 2975 0.0277459108298973 1020 4871271 YPR165W RHO1
SGTC_540 1187-0821 17.3 µM -1.91910075966975 0.0943532324107947 no 2976 0.0274857916792344 1060 847520
SGTC_948 3448-0295 75.3 µM -1.91924303466754 0.0943369068454174 no 2977 0.027476791784577 1042 678569
SGTC_1845 st056753 3.01 µM -1.92082062440257 0.0941560234605367 no 2978 0.027377162702639 1043 5375839
SGTC_688 0527-0193 473 µM -1.92169308550872 0.0940560987020184 no 2979 0.0273221939067692 1073 4007154
SGTC_2712 st079126 47.7 µM -1.92254632154636 0.0939584515304238 no 2980 0.0272685254358643 1056 3152970
SGTC_2593 nobiletin 86.24 µM -1.92788336537991 0.0933493594906379 no 2981 0.0269348176319178 1050 72344 An anti-infammatory.
SGTC_3204 9114183 49.47 µM -1.93009439693303 0.0930978810525483 no 2982 0.0267975712908754 1038 17027248
SGTC_83 0170-0301 39.027 µM -1.93244308720287 0.0928312943907236 no 2983 0.0266524201229205 1070 3089716
SGTC_2452 5863136 48.41 µM -1.93772181923464 0.0922341958206085 no 2984 0.0263285852270371 1054 2184096
SGTC_3080 9117754 49.47 µM -1.93880694508244 0.0921118059146152 no 2985 0.0262624250687977 1052 9550191
SGTC_16 erodoxin 22.806 µM -1.9436506115304 0.0915669611545516 no 2986 0.0259687990738019 1069 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2919 7978188 46.38 µM -1.94921975292961 0.0909434664396213 no 2987 0.0256345935030653 1059 2980291
SGTC_1575 cyproterone acetate 48 µM -1.95553986881219 0.0902397177270436 no 2988 0.0252596911851832 1060 9880 An androgen receptor antagonist and liver toxin.
SGTC_2271 7849410 118.62 µM -1.95555297028145 0.0902382630837558 no 2989 0.0252589188178729 1064 972430
SGTC_2273 7815444 169.05 µM -1.95590970458309 0.0901986619171424 no 2990 0.0252378959624106 1053 2824616
SGTC_2190 6049624 200 µM -1.96135900711752 0.089595337266702 no 2991 0.024918579195369 1059 2265554
SGTC_1507 4075-3230 155 µM -1.96193211309023 0.0895320601103776 no 2992 0.0248851942354314 1046 659771
SGTC_2018 5133068 143 µM -1.96360667256468 0.089347360893593 no 2993 0.0247878615005885 1056 785362
SGTC_3108 9121785 49.47 µM -1.97037897262311 0.088603285867281 no 2994 0.0243974768180592 1001 17140271
SGTC_137 0438-0332 85.389 µM -1.97041580059684 0.0885992522217122 no 2995 0.0243953680872617 1048 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3216 9129716 49.47 µM -1.97345243752481 0.0882671298997483 no 2996 0.0242220191745353 1038 8056934
SGTC_3171 9103192 49.47 µM -1.97373957621389 0.0882357731195001 no 2997 0.0242056812965644 1079 13018434
SGTC_1558 st069300 45.6 µM -1.97872956961057 0.0876921695223154 no 2998 0.0239232309408669 1059 24208000
SGTC_3034 9090421 49.47 µM -1.97958700118005 0.0875990140988197 no 2999 0.0238749774019597 1060 17173761
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.98429533124956 0.0870887944944161 no 3000 0.0236114631766833 1085 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_801 0866-0028 10.1 µM -1.98869356303989 0.0866141868214017 no 3001 0.0233675184619921 1067 6849771
SGTC_2596 sinensetin 100 µM -1.99883523080643 0.0855271847464063 no 3002 0.0228130922542292 1054 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1379 2144-0755 36.5 µM -2.00566524833113 0.0848009089935556 no 3003 0.0224459876535583 1053 5392327
SGTC_2099 5377090 177.372 µM -2.00668818461163 0.0846925335409174 no 3004 0.0223914374432871 1057 2243829
SGTC_2516 gossypol 71.55 µM -2.01137750995513 0.0841970500261163 no 3005 0.0221427985144576 1066 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1798 st045719 60.953 µM -2.01506992769688 0.083808435378825 no 3006 0.0219486613257937 1057 3980186
SGTC_610 4215-0184 155 µM -2.01965427740624 0.0833278244698057 no 3007 0.0217096304399372 1029 5605015
SGTC_2204 7233102 200 µM -2.0218506657905 0.0830982964389299 no 3008 0.0215958908589743 1066 2172480
SGTC_3126 9127922 49.47 µM -2.02588066719598 0.082678388357761 no 3009 0.0213885074188329 1035 45595682
SGTC_1492 4158-0558 28.5 µM -2.02631816283924 0.0826328995335357 no 3010 0.0213660955916383 1065 3967268
SGTC_280 3448-3607 3.04 µM -2.02694429733922 0.082567829665943 no 3011 0.0213340548057458 1038 626179
SGTC_190 3970-0790 3.722 µM -2.02869685095371 0.0823859038477247 no 3012 0.021244588423604 1070 2832352
SGTC_1929 genistein trimethyl ether 50.5 µM -2.04408824654251 0.0808011274716827 no 3013 0.0204724150315153 1049 136420
SGTC_1809 st050081 57.6 µM -2.0458483039978 0.0806213796399945 no 3014 0.0203856489320156 1064 5036894
SGTC_3178 9107506 49.47 µM -2.05691244990286 0.079498351492833 no 3015 0.0198473240943397 1072 8897194
SGTC_781 4335-2806 94.4 µM -2.05763707310386 0.0794252162379138 no 3016 0.0198124925433961 1074 845254
SGTC_2644 guaiazulene 100 µM -2.05808791955796 0.0793797386099421 no 3017 0.0197908472228013 1066 3515 A coloring agent.
SGTC_2904 7225135 42.03 µM -2.05847574438887 0.0793406338493937 no 3018 0.0197722436581899 1081 4446116
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -2.05933806280439 0.0792537376922574 no 3019 0.0197309323056407 1074 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_338 4055-0136 114 µM -2.06929348202765 0.0782557377466517 no 3020 0.0192592774602724 1082 2900563
SGTC_252 miconazole 1.30953 nM -2.06965403216248 0.0782197733757821 no 3021 0.0192423771549827 1046 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_839 0122-0028 230 µM -2.07716398216189 0.0774735132825625 no 3022 0.0188932134605406 1058 759448
SGTC_2090 5301565 104.445 µM -2.07808222840956 0.0773826398225813 no 3023 0.0188508931003853 1072 2056344
SGTC_2174 5790901 200 µM -2.07841890320043 0.0773493413794848 no 3024 0.0188353965688415 1069 786020
SGTC_288 1315-0019 35.1 µM -2.07959964847215 0.0772326471067485 no 3025 0.0187811346332252 1045 6811474
SGTC_1476 4112-3294 3.34 µM -2.09041294402762 0.0761701717808242 no 3026 0.0182903605665438 1025 704369
SGTC_1785 bathophenanthroline 24 µM -2.09067571871207 0.0761444916535906 no 3027 0.0182785715225198 1021 72812 An iron chelator.
SGTC_36 0335-0881 14.2 µM -2.09168055242568 0.0760463532573701 no 3028 0.0182335506615673 1042 23828853
SGTC_2187 6125751 200 µM -2.09304420603992 0.0759133242993389 no 3029 0.0181726042838871 1079 874498
SGTC_3000 9075062 71.4286 µM -2.09380847991724 0.0758388443638905 no 3030 0.0181385222348158 1042 17057871
SGTC_1872 amphotericin b 148 nM -2.0994624540039 0.0752895815949152 no 3031 0.0178880771173892 1066 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2898 9056270 58.44 µM -2.10034864016914 0.0752037674711501 no 3032 0.0178490917269303 1050 19154699
SGTC_117 lucigenin 22.078 µM -2.1041175928714 0.0748396325618199 no 3033 0.0176840952871491 1065 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1493 4348-0038 111 µM -2.10839056728681 0.0744284306314149 no 3034 0.0174986098442174 1063 800424
SGTC_171 k064-0041 9.68 µM -2.1104061233237 0.0742350669845712 no 3035 0.0174116947471611 1049 53325
SGTC_1509 1326-1131 80 µM -2.11346583261514 0.0739422654244279 no 3036 0.0172804582238482 1050 768313
SGTC_1494 4358-1428 177 µM -2.128380661614 0.0725275988675547 no 3037 0.0166527675966365 1069 1564571
SGTC_50 0929-0078 56.389 µM -2.13378687184858 0.0720199726623682 no 3038 0.016430115514259 1045 1377751
SGTC_2727 riluzole 51.77 µM -2.14549991976411 0.0709295031367363 no 3039 0.0159564489156311 1077 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1309 pyrazolanthrone 13.4 µM -2.15193169806448 0.0703361313654743 no 3040 0.015701367128009 1073 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1814 st052110 31.539 µM -2.15282312013024 0.0702541941626103 no 3041 0.0156662911908017 1070 674163
SGTC_936 3005-4620 401 µM -2.15343716731509 0.0701977952516107 no 3042 0.0156421686045733 1069 777207
SGTC_12 0849-0099 9.267 µM -2.15436598200496 0.0701125518066186 no 3043 0.0156057410731267 1084 6071388
SGTC_1982 st072467 71.9 µM -2.15859909381945 0.069725059349901 no 3044 0.015440641563744 1070 3163533
SGTC_2113 5491891 107.031 µM -2.15932456864329 0.0696588163031121 no 3045 0.0154124976866023 1063 789979
SGTC_2258 7960471 200 µM -2.15943332761335 0.0696488897080302 no 3046 0.0154082823185904 1082 2974708
SGTC_3269 9137823 49.47 µM -2.16246449442697 0.0693726684646626 no 3047 0.0152911955016188 1064 17682936
SGTC_3124 9127567 49.47 µM -2.16487510816632 0.0691535993485479 no 3048 0.0151986254649356 1063 17592030
SGTC_1443 4112-3303 14 µM -2.16532595311759 0.0691126871884937 no 3049 0.0151813661009533 1076 704433
SGTC_611 3453-1652 23.7 µM -2.16828846717605 0.068844316108448 no 3050 0.0150683726788029 1081 1560575
SGTC_1036 k216-0215 33.5 µM -2.17011190936766 0.0686795322512999 no 3051 0.0149991846011448 986 622330
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.17275787081549 0.0684409587446174 no 3052 0.0148992728223875 1078 688803
SGTC_2871 9038510 12.99 µM -2.17674525937639 0.0680826436799613 no 3053 0.0147497896911174 1074 4945164
SGTC_3107 9121808 49.47 µM -2.18249664099566 0.067568365633283 no 3054 0.0145364494473962 1056 662681
SGTC_1827 berberine 7.24 µM -2.18279891261081 0.0675414203092434 no 3055 0.0145253109000808 1029 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2480 5767542 37.17 µM -2.18424220751107 0.0674128754898972 no 3056 0.0144722274778909 1075 2867358
SGTC_2344 7990960 76.95 µM -2.18633375854965 0.0672269304009972 no 3057 0.0143955980205027 1048 140813
SGTC_2762 leflunomide 42.06 µM -2.19699128296148 0.0662855970551222 no 3058 0.0140105343866544 1082 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1527 coumarin 137 µM -2.20362210869877 0.0657050962043924 no 3059 0.0137754655607961 1076 323 A hepatotoxic, DNA x-linker.
SGTC_1797 st048695 56.8 µM -2.20935961811466 0.0652059886836674 no 3060 0.013574818729702 1065 592262 YIL048W NEO1
SGTC_3025 9087895 49.47 µM -2.21138743353815 0.0650302937471688 no 3061 0.0135045096520914 1069 17173641
SGTC_3170 9103054 49.47 µM -2.21856900015127 0.0644110187837133 no 3062 0.0132580302472177 1058 16432970
SGTC_2350 9023895 38.85 µM -2.21912282648382 0.0643634526476828 no 3063 0.0132391847486641 1059 2997209
SGTC_121 0557-0495 61.343 µM -2.22031433161576 0.0642612111264918 no 3064 0.013198718874015 1080 3104427
SGTC_1315 1237-0019 3.69 µM -2.22153852220396 0.0641562964223934 no 3065 0.0131572542854352 1059 825140
SGTC_3343 9148379 18.9835 µM -2.22348207331928 0.0639900051596274 no 3066 0.0130916554380387 1054 1955036
SGTC_2490 carminic acid 95.39 µM -2.22769736064921 0.0636304948159297 no 3067 0.0129503515739541 1064 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_119 0121-0043 24.815 µM -2.22801788272191 0.0636032227860759 no 3068 0.0129396612627524 1065 1092378
SGTC_423 5-fluorouracil 457 µM -2.22912636220373 0.0635089765070424 no 3069 0.0129027491654909 1054 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_428 3448-4153 16.5 µM -2.23363895822193 0.0631264233762066 no 3070 0.0127534191933531 1067 3834874
SGTC_545 4218-0007 221 µM -2.23788819519991 0.0627678391709491 no 3071 0.0126141735208937 1075 2840508
SGTC_846 0335-0850 148 µM -2.23886918920943 0.0626852810960096 no 3072 0.0125822143750167 1071 6819598
SGTC_2925 9010536 32.5 µM -2.25656362578585 0.0612106460500268 no 3073 0.0120176776968914 988 2994177
SGTC_2074 5212007 75.395 µM -2.26356242125298 0.0606349107326013 no 3074 0.0118005206624661 1071 758611
SGTC_1698 5-fluorocytosine 1.055 µM -2.2639952883801 0.0605994417617269 no 3075 0.0117872022834479 1070 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1799 st045822 46.1415 µM -2.26545900786637 0.0604796253562213 no 3076 0.0117422634020206 1056 3674992
SGTC_2086 5274770 176.623 µM -2.26785857093694 0.0602836042504972 no 3077 0.0116689140719269 1072 689278
SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.28064545154457 0.0592474130436632 no 3078 0.0112847177193152 1081 140250 A respiratory chain inhibitor.
SGTC_1689 st020265 53.493 µM -2.28374196703801 0.0589985980973446 no 3079 0.0111933500390192 1071 5758320 YPR016C TIF6
SGTC_546 peri-Naphthalide 147 µM -2.28613263115006 0.0588070619206395 no 3080 0.0111232502545767 1077 223824 A penicillin ester.
SGTC_1996 st072960 66.8 µM -2.29454990423095 0.0581365650639474 no 3081 0.0108794659999607 1081 1719405
SGTC_439 amiodarone 34.4 µM -2.30003489635338 0.0577028879858734 no 3082 0.0107231215510255 1070 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_645 0845-0943 5.41 µM -2.30017384161986 0.057691935249008 no 3083 0.0107191865879216 1075 1885106
SGTC_2584 androsterone 48.74 µM -2.30447912867084 0.0573533687646064 no 3084 0.0105978813181258 1033 2754130 A steroid.
SGTC_2890 9046729 58.44 µM -2.30517202202948 0.0572990261835617 no 3085 0.0105784705651352 1077 903329
SGTC_37 0566-0070 1.56 µM -2.30954881185578 0.0569566969148388 no 3086 0.0104565731673061 1078 1626686
SGTC_1153 4055-0057 267 µM -2.31659380257303 0.0564090597289001 no 3087 0.0102629346450356 1076 882706
SGTC_3215 9129942 49.47 µM -2.3167699755499 0.0563954184281866 no 3088 0.0102581327035111 1074 17682944
SGTC_2230 bromochlorosalicylanilide 954.5 nM -2.31811934540474 0.0562910211893969 no 3089 0.0102214179047619 1071 77254
SGTC_2378 9074213 121.43 µM -2.32010479473062 0.0561376892083928 no 3090 0.0101676045149581 1074 657714
SGTC_1834 st055981 52.8 µM -2.32203063769536 0.0559892753510092 no 3091 0.010115642990637 1078 471719 YDL150W RPC53
SGTC_2566 crystal violet carbinol 226 nM -2.32690044959314 0.05561536703823 no 3092 0.00998528214035681 1067 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2612 dictamnine 15.46 µM -2.33351786284669 0.055110438392041 no 3093 0.00981049095778899 1053 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2305 7443522 69.23 µM -2.33943507437432 0.0546620106689579 no 3094 0.00965646403366049 1065 5415886
SGTC_113 0099-0221 2.5 µM -2.3406795142826 0.0545680706809906 no 3095 0.00962434115458466 1073 89219
SGTC_29 0299-0004 12.984 µM -2.34419097290945 0.054303686785066 no 3096 0.00953420249649672 1076 16871 A napthoquinone isolated from Swertia calycina.
SGTC_745 0469-0705 296 µM -2.35144994792973 0.0537603593229973 no 3097 0.00935020266672761 1075 3486736
SGTC_2323 6148992 148.28 µM -2.35199368792029 0.0537198348402656 no 3098 0.00933654590256106 1075 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2006 4011487 200 µM -2.35291882155736 0.0536509410156511 no 3099 0.00931335002404233 1072 45595294
SGTC_2109 5483026 200 µM -2.35451580046367 0.0535321802086324 no 3100 0.00927342759493537 1076 759335
SGTC_2484 5809818 12.04 µM -2.36079007719984 0.0530676032826191 no 3101 0.00911802505998948 1071 2870548
SGTC_818 4072-2707 53.5 µM -2.3630279766103 0.0529026743201429 no 3102 0.00906315058860662 1067 882871
SGTC_294 k038-0071 157 µM -2.36672562488461 0.05263105577631 no 3103 0.00897311588093001 1088 24152826
SGTC_1081 sertraline 6 µM -2.36709282523728 0.0526041428197534 no 3104 0.00896421776579267 1072 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_618 k072-0232 33.2 µM -2.36717352355109 0.0525982297192586 no 3105 0.00896226329509118 1053 5872756 YGL099W LSG1
SGTC_2756 carbadox 75.1 µM -2.367734292563 0.0525571544132974 no 3106 0.00894869207201051 1052 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2469 5655019 90.81 µM -2.37046852587969 0.0523572413942212 no 3107 0.00888277822686844 1079 2788239
SGTC_1773 st048542 73.5835 µM -2.37163025673447 0.0522724846026541 no 3108 0.00885490154938122 1081 3237138
SGTC_409 arachidonic acid 100 µM -2.37265702590314 0.0521976649939684 no 3109 0.0088303272448826 1076 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2607 solasodine 47.35 µM -2.37706680364999 0.0518772956513976 no 3110 0.00872546366786794 1075 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2949 9072542 2.23 µM -2.38038552312721 0.0516372234938239 no 3111 0.00864726686112357 1076 16457352
SGTC_266 formosanin C 406 nM -2.38596932648004 0.0512352919991905 no 3112 0.00851708587871676 1067 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_18 0111-0177 500 nM -2.39691361015331 0.0504547271134472 no 3113 0.00826691068945791 1089 721752
SGTC_1596 piperlongumine 63 µM -2.39918979911639 0.0502935817945516 no 3114 0.00821569764268858 1074 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_416 estradiol valerate 100 µM -2.40190875539246 0.0501016282053844 no 3115 0.0081548880299224 1083 13791 A steroid.
SGTC_2100 5377183 190 µM -2.4040033433865 0.0499541526047214 no 3116 0.00810831248560365 1065 2844202
SGTC_3316 9136639 10.545 µM -2.40777063476264 0.0496897768700314 no 3117 0.00802513058772178 1071 4903665
SGTC_472 calcifediol 10 µM -2.41282744316985 0.04933666350561 no 3118 0.00791465587216307 1089 5283731 A vitamin D metabolite.
SGTC_3284 9108171 64.8615 µM -2.43235518798593 0.0479918236906554 no 3119 0.00750049435770213 1067 8687505
SGTC_1886 st057356 49.9 µM -2.4332021415088 0.0479341661028435 no 3120 0.00748297158348902 1083 24207747
SGTC_2145 5634607 200 µM -2.43836149791221 0.0475841321820564 no 3121 0.00737700566442162 1085 308662
SGTC_1144 3486-0183 12.5 µM -2.43865985420195 0.0475639531389051 no 3122 0.00737091849792451 1078 6744069
SGTC_580 1123-0028 41 µM -2.44508142806136 0.0471312952526158 no 3123 0.00724097205400031 1083 1677248 YPR107C YTH1
SGTC_236 1509-0011 5.31 µM -2.44964789463501 0.0468255503648787 no 3124 0.00714979858766609 1081 3107280
SGTC_1930 st074634 34.3 µM -2.45226168612705 0.0466512628097492 no 3125 0.00709806897869008 1071 684253 YOR116C RPO31
SGTC_3141 9094609 49.47 µM -2.45441065011521 0.0465083601742847 no 3126 0.00705578643193579 1066 25236309 YDL196W YDL196W
SGTC_2320 7373003 200 µM -2.45855288030331 0.0462338999580345 no 3127 0.00697491154546469 1065 5415828
SGTC_666 0272-0154 136 µM -2.46609377403033 0.0457375877943519 no 3128 0.00682977842917762 1089 6870312
SGTC_1010 4112-3296 15.2 µM -2.46694219647831 0.0456820169641236 no 3129 0.00681361768964815 1068 704384
SGTC_198 3454-2873 16.191 µM -2.47096148671961 0.0454194946224942 no 3130 0.00673751649920791 1086 710957
SGTC_917 harmaline 728.087 nM -2.48044610612348 0.0448048097225503 no 3131 0.00656090492882864 1070 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_22 0964-0034 14.468 µM -2.48329957241366 0.0446211969548781 no 3132 0.00650857823712338 1079 138402
SGTC_2508 celastrol 40.54 µM -2.48429045618365 0.044557578243245 no 3133 0.00649049401081541 1073 122724 Celastrol is a natural product and antioxidant.
SGTC_842 0271-0008 11.1 µM -2.48977289903323 0.0442069028399222 no 3134 0.00639123718073219 1071 1221709
SGTC_2123 5259487 200 µM -2.4933068030396 0.0439820440841771 no 3135 0.00632797186453259 1085 2173474
SGTC_2759 disulfiram 3.38 µM -2.49378158864746 0.0439519043628851 no 3136 0.00631951444981681 1074 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3152 9099253 49.47 µM -2.49546431874899 0.043845217595324 no 3137 0.00628962029242559 1060 25236131
SGTC_1011 4112-3381 17.4 µM -2.4998010053076 0.0435712300426766 no 3138 0.00621315423228852 1079 2877139
SGTC_469 w7 172 µM -2.50258975523386 0.0433957707670957 no 3139 0.00616441800091737 1090 45115570 A P450 inhibitor.
SGTC_2837 9008476 45.46 µM -2.50686803252147 0.0431277044372093 no 3140 0.00609030894199429 1073 2992805
SGTC_765 1319-0117 244 µM -2.50823291895326 0.043042465985166 no 3141 0.0060668328231029 1070 3487746 YGL099W LSG1
SGTC_641 4092-0595 30 µM -2.51156638610435 0.0428348598412453 no 3142 0.00600983380648013 1088 786260
SGTC_1663 st014140 55.4 µM -2.51313674831689 0.0427373395275383 no 3143 0.0059831470242751 1082 4207120
SGTC_722 3534-0461 190 µM -2.51441031070799 0.0426583825018532 no 3144 0.00596158127374868 1081 658262
SGTC_943 3253-1379 105 µM -2.51566448562005 0.042580742738159 no 3145 0.00594041120244039 1072 668464
SGTC_200 k038-0079 37.545 µM -2.53447250056693 0.0414300786764297 no 3146 0.00563083829204019 1090 3436683
SGTC_2726 cimetidine 79.27 µM -2.53466187335957 0.0414186223816209 no 3147 0.00562779553634816 1086 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2941 9056145 11.23 µM -2.53552009525674 0.0413667355743699 no 3148 0.00561402431270958 1073 2119517
SGTC_1569 carminic acid 40.6 µM -2.54779533070502 0.0406303428582089 no 3149 0.00542030255032666 1083 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2202 7226349 200 µM -2.550432592394 0.0404735299864458 no 3150 0.00537946636905041 1079 844334
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.55303148878272 0.0403194793863391 no 3151 0.00533949205966626 1075 5024745
SGTC_1383 3049-0032 20.7 µM -2.5576247837366 0.0400483747908142 no 3152 0.00526948694637827 1078 712864
SGTC_2779 methotrexate 400 µM -2.55790765743709 0.0400317276070047 no 3153 0.00526520255727453 1061 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2284 7945075 39.21 µM -2.56555040977304 0.0395840740916984 no 3154 0.00515061259002854 1076 1245402
SGTC_226 1,3-diallylurea 8.28947 mM -2.56626412935546 0.0395424785729597 no 3155 0.00514002575055332 1085 74537 YKL182W FAS1
SGTC_1404 3909-7820 48.3 µM -2.59287499842365 0.0380168004566044 no 3156 0.00475886784440288 1056 23741373
SGTC_3276 9139060 49.47 µM -2.60082528592854 0.0375704193636697 no 3157 0.00464999020972847 1090 4870619
SGTC_135 0933-0004 26.348 µM -2.6059629907704 0.0372842381184261 no 3158 0.00458081801086631 1070 21230617 YGL099W LSG1
SGTC_2348 9022543 33.42 µM -2.61154725304151 0.0369752050705462 no 3159 0.00450667654428213 1067 3162678 YDL140C RPO21
SGTC_1619 st003326 88.7 µM -2.61743347271971 0.0366517317616164 no 3160 0.0044296878015625 1053 2849032
SGTC_1368 1852-0141 284 µM -2.62240736236332 0.0363802027523208 no 3161 0.00436555002990483 1081 2838987
SGTC_1971 st069429 63.5 µM -2.62372290238457 0.0363086622297774 no 3162 0.00434872564915727 1087 1246522 YGL099W LSG1
SGTC_2075 5212009 200 µM -2.62689745844879 0.0361365005105379 no 3163 0.00430836479944633 1082 780898
SGTC_466 geldanamycin 89.2 µM -2.62776830550796 0.0360893899649569 no 3164 0.00429735166075897 1088 5288382 HSP90 inhibitor.
SGTC_2699 st077704 54.6 µM -2.63136821907652 0.0358951774756043 no 3165 0.00425209204489123 1081 645852
SGTC_1442 4112-3290 3 µM -2.6329950178585 0.0358076942875898 no 3166 0.00423177944232422 1091 704353
SGTC_97 0535-0701 19.132 µM -2.63457265579851 0.035723021726331 no 3167 0.00421216360109728 1062 2832013 YGL099W LSG1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.64745223534986 0.0350378894281186 no 3168 0.00405504078768711 1084 6710655
SGTC_1310 1188-0297 994 nM -2.65131033952553 0.0348347682836855 no 3169 0.00400900653272493 1058 1588352
SGTC_299 1273-0059 1.44 µM -2.65577982096898 0.0346006691184543 no 3170 0.00395626288085188 1065 2848077
SGTC_682 0kpi-0099 17 µM -2.6589518468228 0.0344353123265761 no 3171 0.00391920825664591 1084 1714895 YML126C ERG13
SGTC_216 k038-0035 28.382 µM -2.66426456501596 0.0341598166630549 no 3172 0.00385784272000191 1089 4444231 YPR107C YTH1
SGTC_1638 st008370 60.6 µM -2.67570050543905 0.0335729419749293 no 3173 0.00372866258340255 1069 24207134
SGTC_689 0833-0039 98 µM -2.67924667829001 0.0333926526699065 no 3174 0.00368940060765328 1083 5374726
SGTC_576 1073-0113 22.7 µM -2.69847559634087 0.0324288750045434 no 3175 0.00348289224484892 1083 5439563
SGTC_1664 st014217 9.02 µM -2.69851384162344 0.0324269812182691 no 3176 0.00348249207059262 1077 3982782
SGTC_2689 tacrolimus 100 µM -2.70263308376211 0.0322235428020982 no 3177 0.00343963194669272 1063 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1188 1403-0014 4.57 µM -2.70673492268577 0.032022011836202 no 3178 0.00339742441059705 1084 9614867
SGTC_1969 st069479 40.1 µM -2.71975136424789 0.031389370628279 no 3179 0.00326655096771674 1086 3895485
SGTC_1995 st072814 61.1 µM -2.72165398351228 0.0312977687391795 no 3180 0.00324780576829792 1089 5769371
SGTC_2640 pentamidine 10.38 µM -2.72735652741562 0.0310245423046848 no 3181 0.00319220075418177 1043 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_635 k038-0028 24.7 µM -2.74689605508107 0.0301032708438347 no 3182 0.00300810991613089 1090 4035102
SGTC_709 3807-1509 243 µM -2.7581382482951 0.0295835690938951 no 3183 0.00290658035556053 1090 1886677 YPL242C IQG1
SGTC_155 k072-0202 43.6 µM -2.77689554024506 0.0287330487216976 no 3184 0.00274404069047352 1089 5857737
SGTC_3067 9117431 49.47 µM -2.78149052438952 0.0285278256339873 no 3185 0.00270549551235916 1089 17150885
SGTC_193 1273-0060 1.558 µM -2.78816293147606 0.0282319918845293 no 3186 0.00265039384358016 1078 2847393 YHR072W ERG7
SGTC_790 1575-0012 79.1 µM -2.78965198725718 0.0281663214976495 no 3187 0.00263823621087593 1080 378741 YLR208W SEC13
SGTC_2952 9073731 13.78 µM -2.79816860126728 0.027793160781661 no 3188 0.00256966390193495 1088 16457353
SGTC_2451 5856223 45.7 µM -2.80012845898683 0.0277078739282873 no 3189 0.00255411370238406 1081 2179896
SGTC_820 1582-0060 59.9 µM -2.80702559218595 0.0274094648439067 no 3190 0.00250006345501773 1087 3848840
SGTC_932 2857-0803 154 µM -2.81926586535276 0.0268864802328658 no 3191 0.00240668160002284 1088 674898
SGTC_2411 st077133 39.94 µM -2.82150823470023 0.0267915801750716 no 3192 0.00238992051724074 1078 1403142 YNL221C POP1
SGTC_2910 7948405 25.97 µM -2.82230550320003 0.026757906184108 no 3193 0.00238398666291289 1083 2971328
SGTC_3213 9129884 49.47 µM -2.82297813757945 0.0267295238225513 no 3194 0.00237899080032606 1081 17190742
SGTC_2077 5212015 200 µM -2.82596418987031 0.0266038282709542 no 3195 0.00235692667785557 1082 780900
SGTC_1615 st002656 86.5 µM -2.84324339886623 0.0258861320406904 no 3196 0.00223284762167129 1090 1584458
SGTC_2359 9039622 200 µM -2.84947421545382 0.0256313395382158 no 3197 0.00218957775807517 1093 6463596
SGTC_3032 9089427 49.47 µM -2.87281822398943 0.0246953430731944 no 3198 0.00203414061639492 1060 17173707
SGTC_41 0478-0632 82.643 µM -2.87367789558586 0.0246614286704117 no 3199 0.00202861256747787 1077 3750424
SGTC_2338 7999974 200 µM -2.88161825806217 0.024350021519953 no 3200 0.00197819369434082 1073 315925
SGTC_1354 1498-1681 81 µM -2.88303227577674 0.0242949139946876 no 3201 0.00196933541112557 1089 5754243
SGTC_3249 9135183 49.47 µM -2.89797944926495 0.0237187663447277 no 3202 0.00187787599268874 1068 4902779
SGTC_1133 3473-0247 50 µM -2.90483264736009 0.0234584721021765 no 3203 0.00183724755925189 1074 711311
SGTC_2429 5902844 64.44 µM -2.90800339987811 0.0233388580273457 no 3204 0.0018187219149899 1091 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1808 st050063 61.5 µM -2.91486837700711 0.0230816402493762 no 3205 0.00177919291148693 1089 4011993
SGTC_3027 9089541 49.47 µM -2.91503791272066 0.0230753183906576 no 3206 0.00177822667903333 1091 9943819
SGTC_165 k038-0023 64.381 µM -2.92748719620332 0.0226150622958464 no 3207 0.00170856565193167 1089 46368543
SGTC_3214 9129694 49.47 µM -2.93014328173496 0.022517873729533 no 3208 0.00169402871106613 1087 17158655
SGTC_1784 st039334 36.3 µM -2.9304522667912 0.0225065905889576 no 3209 0.00169234494685631 1082 3496984
SGTC_2326 6164455 177.58 µM -2.94556871488705 0.0219603792913872 no 3210 0.00161180768038095 1085 2888790
SGTC_2514 salinomycin 42.74 µM -2.95826764276631 0.0215102121980559 no 3211 0.0015468669067357 1090 23682228 A polyether potassium ionophore.
SGTC_1554 st069299 38.7 µM -2.96257258938811 0.0213593862576143 no 3212 0.0015253993276407 1091 24207999
SGTC_2206 7254556 146.969 µM -2.96442710500452 0.0212946884953073 no 3213 0.00151623539212784 1091 4398905
SGTC_990 3985-0011 41.3 µM -2.9951687366849 0.0202461287227658 no 3214 0.00137146529280986 1074 5399565 YGL099W LSG1
SGTC_2914 7968218 45.32 µM -2.99910175438801 0.0201151909384562 no 3215 0.00135388428802721 1088 2977111
SGTC_1824 st053723 68.6 µM -3.00032708064935 0.0200745444657914 no 3216 0.00134844917075731 1092 675225
SGTC_1652 st011932 78 µM -3.00398240265047 0.0199537039286323 no 3217 0.00133235368494283 1085 1551076
SGTC_1968 st069590 43.6 µM -3.01426558610476 0.0196170597406505 no 3218 0.00128801096635102 1083 6384066
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -3.0155036314672 0.0195768565791639 no 3219 0.00128276433367611 1087 688664
SGTC_1033 k072-0102 21.3 µM -3.02239142991214 0.0193544637618191 no 3220 0.00125393013336404 1079 5965931
SGTC_670 4204-0025 119 µM -3.02994925050841 0.0191129110045225 no 3221 0.00122297417287846 1091 719039
SGTC_1855 st056195 39.6 µM -3.07320136069311 0.0177793114891997 no 3222 0.00105887768305235 1077 4028379
SGTC_2442 5158906 48.48 µM -3.07332276647403 0.017775682856462 no 3223 0.00105844695135191 1088 1893835
SGTC_1801 st050089 28.441 µM -3.09969871835747 0.0170021808882913 no 3224 0.000968587905581078 1092 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2364 9055074 200 µM -3.10029057759708 0.0169851593992984 no 3225 0.000966654376216125 1088 6470630
SGTC_1407 3909-7909 12.3 µM -3.10220362788061 0.0169302409216505 no 3226 0.00096042889813828 1081 4411780
SGTC_586 0957-0265 8.15 µM -3.10339158236063 0.0168962144450949 no 3227 0.00095658159019722 1076 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1074 carmofur 3.8 µM -3.10510383712966 0.0168472733778196 no 3228 0.000951061181155017 1093 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1371 2421-0008 32.7 µM -3.12493505845253 0.01628921840071 no 3229 0.00088922158913905 1077 2827552
SGTC_2600 tangeritin 87.95 µM -3.12903205902316 0.0161759225164999 no 3230 0.000876915860037077 1086 68077 A bioactive flavone.
SGTC_690 glyoxal 20.3 µM -3.1387662559337 0.0159094436542453 no 3231 0.00084830361573571 1088 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -3.16694042639846 0.0151592737840633 no 3232 0.00077025936849186 1091 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_467 ro 31-8220 72.8 µM -3.16768214709775 0.0151399423311703 no 3233 0.000768297094429653 1086 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_297 0986-0032 24 µM -3.17119943370488 0.0150485594698743 no 3234 0.000759054396853063 1093 2847425
SGTC_450 aminopyrene 156 nM -3.17288370046941 0.0150049685302544 no 3235 0.000754664857547833 1091 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_370 0180-0345 38.7 µM -3.18597666671541 0.0146697924143164 no 3236 0.000721331160189205 1070 3989527
SGTC_2483 5729050 27.16 µM -3.20541475306728 0.0141840712082041 no 3237 0.000674339948740739 1089 2865180
SGTC_2004 4023728 41.89 µM -3.21089909983249 0.0140495592688865 no 3238 0.000661601932196002 1090 360084 YDR527W RBA50
SGTC_1548 st061468 90.8 µM -3.2392558674436 0.0133714695110412 no 3239 0.000599210059458448 1093 390799
SGTC_1256 0570-0116 285 µM -3.24250146882677 0.0132956909115892 no 3240 0.000592426687582332 1093 410638
SGTC_1620 st003704 16.5 µM -3.25613205210739 0.0129814793388406 no 3241 0.000564706052902654 1093 2834414
SGTC_3197 9113331 49.47 µM -3.26939664470335 0.0126818891685058 no 3242 0.000538885517111342 1082 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1269 0831-0796 3.05 µM -3.2833737182293 0.0123726993480454 no 3243 0.000512862941945205 1073 927758
SGTC_946 3434-1334 87.4 µM -3.31238163540788 0.0117517871514594 no 3244 0.000462526305026426 1092 4047976
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -3.31589901357978 0.0116783681611488 no 3245 0.000456744160023635 1095 23665772 A membrane-active detergent.
SGTC_2813 7971799 71.43 µM -3.33076093263896 0.0113725305021245 no 3246 0.000433044746472612 1093 2234054
SGTC_3247 9135149 49.47 µM -3.33295331172972 0.0113280085866147 no 3247 0.000429646803894258 1086 8934436 YOR116C RPO31
SGTC_2928 9011484 9.79 µM -3.33298680707174 0.0113273295536775 no 3248 0.000429595082142526 1081 2994751
SGTC_2980 9014342 25.29 µM -3.35112411173726 0.010964797928813 no 3249 0.000402421109431348 1072 2996599
SGTC_1346 1488-2224 62.4 µM -3.36654837896993 0.0106644802798818 no 3250 0.000380576148674727 1092 3722427
SGTC_2425 5628681 7.85 µM -3.37131692512091 0.0105730959072967 no 3251 0.000374048711394772 1092 5714958
SGTC_2894 9048625 32.47 µM -3.37836037881855 0.010439363404939 no 3252 0.000364597254576572 1087 4092861
SGTC_607 4491-0986 66.8 µM -3.38835711036551 0.0102520896519042 no 3253 0.000351563268712938 1077 698981 YDR232W HEM1
SGTC_2117 5521686 200 µM -3.39346416679352 0.010157552334116 no 3254 0.000345072935498893 1094 803312
SGTC_1634 st006576 41 µM -3.39632711208367 0.0101048893956353 no 3255 0.000341483435001194 1090 3915356
SGTC_1917 st066507 28.5 µM -3.39870798314649 0.0100612756530939 no 3256 0.000338524815111035 1074 3156428
SGTC_1453 4237-0541 195 µM -3.41619673795267 0.00974591496494648 no 3257 0.000317511752771218 1089 739892
SGTC_246 cycloheximide 667 µM -3.43318448501966 0.00944789121946221 no 3258 0.000298268025056309 1092 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_143 4032-1194 15.74 µM -3.44329693405264 0.00927429419641875 no 3259 0.000287333988886746 1090 1806963
SGTC_902 1120-0002 2.07 µM -3.44738427725726 0.00920492414954475 no 3260 0.000283021420914608 1084 3280475
SGTC_796 1234-0020 70.7 µM -3.45455465992568 0.00908432576535253 no 3261 0.000275601235811517 1091 46495034
SGTC_897 1000-0139 31.4 µM -3.46820480690166 0.00885856375499475 no 3262 0.000261973904158579 1091 6151020
SGTC_1 0258-0098 57.368 µM -3.47772358682552 0.00870405533273972 no 3263 0.000252845553471904 1072 6790032 YDR047W HEM12
SGTC_2139 5578692 56.4705 µM -3.479754796325 0.00867139243628453 no 3264 0.000250936443975817 1085 650991 YMR113W FOL3
SGTC_363 0455-0021 3.06 µM -3.48242214398317 0.00862866339836205 no 3265 0.000248449844349203 1082 4597466
SGTC_2124 5246320 200 µM -3.4890106296723 0.0085239110253128 no 3266 0.000242405934787691 1094 579342
SGTC_2180 6301957 200 µM -3.50059838194476 0.00834237887830407 no 3267 0.000232107427945665 1087 845462
SGTC_149 3970-0822 46.1 µM -3.50616956260899 0.00825631629613207 no 3268 0.000227302756335324 1092 3114250 YBL034C STU1
SGTC_2233 sulbentine 40.3845 µM -3.519912128328 0.0080473498969607 no 3269 0.000215844895822071 1076 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_852 0418-0143 439 µM -3.52273765487543 0.00800496639869279 no 3270 0.00021355695827454 1083 5369229
SGTC_2534 helenine 20.12 µM -3.53933773138062 0.00775990297808535 no 3271 0.000200566149046862 1087 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2223 6903751 107.57 µM -3.56176722505116 0.00743927883722294 no 3272 0.000184183458175117 1090 5598863
SGTC_2111 5486399 200 µM -3.56747192422283 0.00735961711543814 no 3273 0.000180220992348897 1090 689674
SGTC_3132 9126706 49.47 µM -3.56815613078245 0.00735011337627286 no 3274 0.000179751135361185 1091 850858
SGTC_2913 7966556 36.57 µM -3.59550943429229 0.00697892522261403 no 3275 0.000161878697206815 1079 2976516
SGTC_3073 9114972 49.47 µM -3.60559190125595 0.00684633736090163 no 3276 0.000155721123408891 1093 41905075
SGTC_2991 9074669 71.4286 µM -3.61338249332617 0.00674541718943994 no 3277 0.000151114177655123 1083 17333109
SGTC_3287 9117173 37.0625 µM -3.61483444684293 0.00672675443424759 no 3278 0.000150269805811875 1083 2789709
SGTC_1844 rapamycin 4 nM -3.61792002877277 0.00668724520749407 no 3279 0.000148490061612546 1081 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_46 0329-0187a 2.197 µM -3.64827160650754 0.00630940893849571 no 3280 0.000132005227185952 1078 46494817
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -3.64914653469066 0.00629880330429738 no 3281 0.000131556497799115 1091 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_965 1291-5240 308 µM -3.66794415107658 0.00607472437613835 no 3282 0.00012225428656071 1095 2834598
SGTC_210 3551-0445 56.827 µM -3.67695507756772 0.005969835556305 no 3283 0.000118017293636919 1084 2865180 YOR207C RET1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -3.73269303232437 0.00535599797618918 no 3284 9.47217069630372e-05 1094 688761
SGTC_3101 9120531 49.47 µM -3.73588830543032 0.00532257364834801 no 3285 9.35268441044043e-05 1094 24824904
SGTC_183 3914-0051 30.55 µM -3.73844037865376 0.00529601092379112 no 3286 9.25826960968862e-05 1093 1596232
SGTC_2679 rapamycin 1 nM -3.74299412755085 0.00524890692477598 no 3287 9.09202401163649e-05 1077 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_208 k072-0098 12.366 µM -3.75407434952449 0.00513584631318725 no 3288 8.69916101533592e-05 1091 5948901
SGTC_1044 1222-0021 1.78 µM -3.75815422802977 0.00509476517559503 no 3289 8.55856846996363e-05 1075 4306703
SGTC_953 1188-0045 9.7 µM -3.76884001788337 0.00498855097590664 no 3290 8.20039799082224e-05 1091 6144426
SGTC_475 α-linolenic acid 10 µM -3.77588952740187 0.00491956476738494 no 3291 7.97188241320692e-05 1094 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_794 k038-0031 316 µM -3.78344138853149 0.0048466068417749 no 3292 7.73373805058958e-05 1094 6624242
SGTC_67 0335-0847 266 µM -3.80357120793049 0.00465682401307006 no 3293 7.13124854194997e-05 1093 4552207 YOR254C SEC63
SGTC_1077 5-fluorocytosine 377 nM -3.81396214901154 0.00456147736462411 no 3294 6.83782113700988e-05 1095 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_778 3456-2434 196 µM -3.82538208516618 0.00445870221825889 no 3295 6.52847097379473e-05 1030 5539063
SGTC_2659 sanguinarine 24.21 µM -3.85588608846956 0.00419424524472328 no 3296 5.76555889054363e-05 1087 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1958 st076513 41.9 µM -3.86497322146255 0.00411822303630051 no 3297 5.55506941339988e-05 1094 732122 YGL099W LSG1
SGTC_1023 4482-3888 16 µM -3.86877362171188 0.00408679656398278 no 3298 5.46920695551355e-05 1093 3303168
SGTC_1587 estradiol valerate 56.1 µM -3.89248386673279 0.00389553174702448 no 3299 4.96115499148271e-05 1091 13791 A steroid.
SGTC_1915 st067105 30.6 µM -3.91458208585856 0.00372453302442711 no 3300 4.52804627419978e-05 1094 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2336 9001819 198.65 µM -3.91861618274269 0.00369405355821515 no 3301 4.45293995327703e-05 1086 2989602
SGTC_1775 st081588 35.1725 µM -3.93649286252178 0.00356166240577814 no 3302 4.13405391176495e-05 1084 1426443 YGL099W LSG1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -3.94254673938241 0.0035178036872658 no 3303 4.03104661342117e-05 1080 688669
SGTC_2930 9013230 14.89 µM -3.95390159298844 0.00343684672281087 no 3304 3.84435212073084e-05 1091 2995857
SGTC_2177 5811945 192 µM -4.0102158938559 0.00305955500826178 no 3305 3.03316271193249e-05 1094 5343475
SGTC_2519 cryptotanshinone 88.04 µM -4.03628794151319 0.00289785946811692 no 3306 2.7151781668729e-05 1089 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1547 harmine 94.2 µM -4.03635747211526 0.00289743875023931 no 3307 2.71437400272589e-05 1087 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2225 6654152 15.4 µM -4.05919368012625 0.00276220338716247 no 3308 2.46212291349668e-05 1092 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1643 st009866 20.2 µM -4.06508250581397 0.00272826667534006 no 3309 2.40077366079961e-05 1092 3156273 YOR207C RET1
SGTC_3222 9128301 49.47 µM -4.07057596206491 0.00269694824287131 no 3310 2.34485228200677e-05 1080 4911358
SGTC_1380 2291-0730 164 µM -4.138889822218 0.00233371652389941 no 3311 1.7449524424461e-05 1094 2999191
SGTC_2152 5568786 200 µM -4.16095850749923 0.0022262119650993 no 3312 1.58457333247872e-05 1095 5399883
SGTC_2592 piperlongumine 83.33 µM -4.17143531005984 0.00217676376495738 no 3313 1.51343495696147e-05 1095 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2391 6285546 200 µM -4.17199162091339 0.00217416615453969 no 3314 1.50974371686025e-05 1095 846083
SGTC_1556 plumbagin 1.48 µM -4.21670011257796 0.00197436832467164 no 3315 1.23951649906669e-05 1076 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_639 0833-0042 114 µM -4.25925944175139 0.00179981758048279 no 3316 1.02552649783935e-05 1093 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2073 5212005 126 µM -4.2657242634074 0.00177456706892214 no 3317 9.96273739873137e-06 1095 691789
SGTC_1831 st055328 12 µM -4.26581494435571 0.00177421518783123 no 3318 9.95869123632351e-06 1095 1103068
SGTC_2510 benzyl isothiocyanate 8.31 µM -4.2728709573438 0.00174702867604549 no 3319 9.64860721249268e-06 1093 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1522 st012842 45.6 µM -4.29065642610096 0.00168017589441464 no 3320 8.9072874398083e-06 1081 3491067 YOR116C RPO31
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -4.31804638992324 0.00158176756786935 no 3321 7.87081745815142e-06 1094 279621
SGTC_2479 5617353 43.85 µM -4.37202848271467 0.00140303927261257 no 3322 6.1548730662181e-06 1095 2731746
SGTC_1130 3454-2858 15.9 µM -4.38006053354041 0.00137808207147347 no 3323 5.93231724892995e-06 1090 715628 YIL048W NEO1
SGTC_829 1635-0120 117 µM -4.38009295477442 0.00137798215917321 no 3324 5.93143466890715e-06 1093 285054
SGTC_2430 5571206 200 µM -4.44546205357103 0.00118947249953891 no 3325 4.3851580642607e-06 1093 1731771
SGTC_2854 9024559 71.43 µM -4.45807343771867 0.00115594197135581 no 3326 4.134978577439e-06 1091 3163529
SGTC_1152 3909-8331 15.9 µM -4.46505655436176 0.00113775017576675 no 3327 4.00238022430112e-06 1095 16001939
SGTC_810 3825-7150 143 µM -4.50085213105599 0.00104854958266243 no 3328 3.38407896485919e-06 1095 22330411 YGL099W LSG1
SGTC_70 0141-0289 43.283 µM -4.59608646312856 0.000841543912362346 yes 3329 2.15250057600818e-06 1091 352408
SGTC_1357 1503-1303 39.5 µM -4.69996040532066 0.00065909367525932 yes 3330 1.30105968857173e-06 1095 292895
SGTC_1098 clofazimine 15.1 µM -4.72127378385465 0.000626496485558666 yes 3331 1.17186101494243e-06 1095 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2487 5918373 44.05 µM -4.79927950633403 0.000519471855230607 yes 3332 7.96187183576963e-07 1095 2876279
SGTC_2645 abamectin 100 µM -4.80272059772519 0.000515165246043085 yes 3333 7.82621126909305e-07 1079 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2544 sphondin 68.51 µM -4.85753626875703 0.000450868933847877 yes 3334 5.94276857416798e-07 1095 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1680 diphenhydramine 100 µM -4.91157184662923 0.000394838785599608 yes 3335 4.51745847901632e-07 1091 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_673 1082-0474 110 µM -4.96039030556341 0.00034984568828804 yes 3336 3.51758400655146e-07 1095 3098046
SGTC_1113 artemisinin 1.17947 µM -4.97189930316444 0.000339956536313412 yes 3337 3.3150070738614e-07 1093 2240 An anti-malaria and mitochondrial poison.
SGTC_3296 9122258 64.045 µM -5.02474254136108 0.000297797957719118 yes 3338 2.52054173439554e-07 1095 4730474
SGTC_674 0498-0004 451 µM -5.04214380709791 0.000285016558360784 yes 3339 2.30172556136802e-07 1091 4231473
SGTC_2066 5222451 176 µM -5.09590807197114 0.000248680851069078 yes 3340 1.73536763587687e-07 1086 2281147
SGTC_3208 9114115 49.47 µM -5.1214303680957 0.000232988055124277 yes 3341 1.51613355254476e-07 1093 650895
SGTC_1786 berberine 21.6 µM -5.13883624426486 0.000222821068109881 yes 3342 1.38222586165815e-07 1085 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2408 sulbentine 18.36 µM -5.15920461734876 0.000211449862623512 yes 3343 1.24000577774299e-07 1090 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1829 berberine 14.4 µM -5.40032485833422 0.000112171915474679 yes 3344 3.32601634315393e-08 1088 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_676 falcarinol 140 µM -5.42283455289886 0.000105587786512614 yes 3345 2.9330641690875e-08 1094 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1880 MG-132 525 µM -5.45207227400654 9.75767097080162e-05 yes 3346 2.48931062960122e-08 1093 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2179 6298986 200 µM -5.65525242792128 5.58061804375317e-05 yes 3347 7.78086956319414e-09 1089 738374
SGTC_2790 5423970 71.43 µM -5.8003088485305 3.70324483651895e-05 yes 3348 3.30964452223602e-09 1095 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2739 tacrine 100.86 µM -5.90703903171617 2.72239624064241e-05 yes 3349 1.74155624965016e-09 1084 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2766 oltipraz 83.91 µM -5.90901387757237 2.7068116771798e-05 yes 3350 1.72080856065576e-09 1088 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_158 k038-0087 26.446 µM -6.17441126558337 1.23178496877393e-05 yes 3351 3.32052331198875e-10 1095 X158
SGTC_490 phenamil 164 µM -6.27194084607969 9.15082933998938e-06 yes 3352 1.78287530023311e-10 1085 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_966 1300-0360 30.2 µM -6.45801020968365 5.1297447734925e-06 yes 3353 5.30442931953505e-11 1094 70588
SGTC_1353 1498-1206 8.11 µM -6.72492811994548 2.17657002263796e-06 yes 3354 8.78395726742862e-12 1090 6756808
SGTC_177 1327-0068 8.361 µM -6.93010612897714 1.10191017065776e-06 yes 3355 2.10262509161854e-12 1095 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_173 1273-0061 2.693 µM -10.2661037065139 1.19023220514749e-12 yes 3356 5.00844484005385e-25 1094 2847414 YPL266W DIM1