SGTCid condition conc unit YDR433W|YDR433W.score YDR433W|YDR433W.strain.pval YDR433W|YDR433W.strain.significant YDR433W|YDR433W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1972 st070201 17.4 µM 9.6730514316172 1.72288331837612e-19 yes 1 1.96248557509482e-22 2 2829099
SGTC_3337 9144342 33.5465 µM 9.53701279008924 5.34967639659805e-19 yes 2 7.35028586775144e-22 4 17682949
SGTC_2333 9017922 200 µM 8.44832523860043 2.63930125751302e-15 yes 3 1.47755594545175e-17 1 3163164
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 7.86775647346008 1.63437072373402e-13 yes 4 1.80528768568581e-15 10 368090
SGTC_2332 7982454 138.89 µM 6.44522117416968 1.212462227742e-09 yes 5 5.77159781867145e-11 15 2981748
SGTC_351 caspofungin 25 nM 6.43795247036772 1.26343618784081e-09 yes 6 6.05479522954932e-11 36 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2991 9074669 71.4286 µM 6.22429083882301 4.15642744096599e-09 yes 7 2.41869502355827e-10 17 17333109
SGTC_2959 9079155 11 µM 6.10691255520839 7.86669794573442e-09 yes 8 5.07884266358089e-10 7 16189457
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 6.08667318870063 8.77128763909664e-09 yes 9 5.76404731540622e-10 17 91467 include heat shock
SGTC_1666 st014829 29 µM 5.53819224457449 1.47135529261409e-07 yes 10 1.5280484805224e-08 12 3858230
SGTC_2601 securinine 100 µM 5.33179553720986 3.98537827710628e-07 yes 11 4.86231982672278e-08 10 442872 A GABA receptor antagonist.
SGTC_1682 st012968 530 nM 5.16920066233319 8.52308512059604e-07 yes 12 1.17548682349148e-07 3 24207270
SGTC_2164 5685496 200 µM 5.14041172559233 9.72881363562422e-07 yes 13 1.3706854697261e-07 10 759046
SGTC_3128 9127691 49.47 µM 5.02687201311554 1.62850471728858e-06 yes 14 2.49272420839655e-07 6 41316314
SGTC_2385 9074692 200 µM 4.78004397540085 4.8110366158621e-06 yes 15 8.76284279508035e-07 25 17046906
SGTC_1649 st011737 51.3 µM 4.68411422369488 7.23110214575014e-06 yes 16 1.40586593456419e-06 20 1761035
SGTC_3334 9142812 21.919 µM 4.680471722814 7.34275912809252e-06 yes 17 1.43107794156179e-06 16 45283678
SGTC_3148 9097893 49.47 µM 4.64320128061591 8.58380629577323e-06 yes 18 1.71525924467117e-06 26 17174100
SGTC_2833 9001315 45.46 µM 4.50780762543069 1.49930718647855e-05 yes 19 3.27504613964957e-06 37 2989378
SGTC_18 0111-0177 500 nM 4.42592332575296 2.08550774080177e-05 yes 20 4.80153160216692e-06 48 721752
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 4.35206960315617 2.79533882328208e-05 yes 21 6.74292156936758e-06 38 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2689 tacrolimus 100 µM 4.24930398003132 4.17102509057329e-05 yes 22 1.07217880682506e-05 40 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_117 lucigenin 22.078 µM 4.22938373111789 4.50299191045076e-05 yes 23 1.17166174073824e-05 75 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_168 3970-0862 530.542 µM 4.21661184495333 4.72879944021566e-05 yes 24 1.24000155611238e-05 105 3135186
SGTC_1651 st011928 86.1 µM 4.19550516011954 5.1255615107404e-05 yes 25 1.36132043830264e-05 11 720198
SGTC_138 0850-0259 40.9225 µM 4.15496081862186 5.97741734107297e-05 yes 26 1.62671644528377e-05 187 6813004
SGTC_1131 3454-3128 32.3 µM 4.12567421300384 6.6739653971295e-05 yes 27 1.84825118722185e-05 37 710982
SGTC_2526 patulin 37.61 µM 4.09457311608422 7.49701595629572e-05 yes 28 2.11473464846482e-05 83 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1380 2291-0730 164 µM 4.08211276730502 7.85283955507008e-05 yes 29 2.23140659135096e-05 22 2999191
SGTC_770 0389-1121 67.2 µM 4.02484871875323 9.7022352995161e-05 yes 30 2.85059769347762e-05 27 6753108
SGTC_3174 9107204 49.47 µM 3.99966520725831 0.00010638911350917 yes 31 3.17160772349208e-05 29 3938802
SGTC_2496 diffractaic acid 79.83 µM 3.97920194779547 0.000114618798973349 yes 32 3.4573493724911e-05 17 94870 An apoptosis inducer which activates caspases.
SGTC_56 0957-0365 83.25 µM 3.92944937044265 0.000137187548777307 yes 33 4.25703001067608e-05 47 6752360
SGTC_2337 9009472 200 µM 3.92430520449667 0.000139744873390021 yes 34 4.34902034066535e-05 36 5742383
SGTC_214 4373-3496 70 µM 3.90756100441686 0.000148381680457744 yes 35 4.6616252976064e-05 57 3779166
SGTC_2485 5633444 17.78 µM 3.89317884145542 0.00015619674403106 yes 36 4.94695786709045e-05 46 5724239
SGTC_1176 0848-0131 83.3 µM 3.8696259011052 0.000169832529218853 yes 37 5.45012404726614e-05 24 6769040
SGTC_3247 9135149 49.47 µM 3.86235285192602 0.000174263272045025 yes 38 5.61501038301826e-05 23 8934436 YOR116C RPO31
SGTC_2553 4-methylesculetin 85.09 µM 3.82856007262153 0.000196304800268371 yes 39 6.44475858544336e-05 27 5319502
SGTC_218 alverine citrate 93.75 µM 3.82804880277663 0.000196657456118842 yes 40 6.45815747575158e-05 34 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2856 9022925 19.48 µM 3.80315548607929 0.000214561854381094 yes 41 7.14323121608966e-05 23 4944862
SGTC_1514 1189-1591 158 µM 3.74972139897181 0.000258254120680173 yes 42 8.85155700519739e-05 42 767698 YMR146C TIF34
SGTC_3098 9119039 49.47 µM 3.69166313506846 0.000315045798176576 yes 43 0.00011139621192028 45 17161528
SGTC_1461 k072-0203 53.8 µM 3.66411522912528 0.00034587699899077 yes 44 0.000124097518996832 21 5418714
SGTC_1063 disulfiram 1.84 µM 3.64214688852518 0.000372449005526229 yes 45 0.00013518685651684 33 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1428 4049-0204 61.7 µM 3.61519197397125 0.000407641192749717 yes 46 0.000150062567831403 22 X1428
SGTC_159 3970-0959 50 µM 3.6143240593909 0.000408824013929445 yes 47 0.000150566112621154 100 6615653
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 3.5652530252612 0.00048112012086331 yes 48 0.000181752663827655 41 5377381
SGTC_262 fenpropimorph 62.5 µM 3.55646142537444 0.000495261392732124 yes 49 0.000187941821370135 36 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1082 camptothecin 424.86 nM 3.52963590410132 0.000540823705727155 yes 50 0.000208065957889585 61 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2106 5357045 167.29 µM 3.50527134335354 0.000585535444758646 yes 51 0.000228071066395861 29 668842
SGTC_1210 3013-0140 750 nM 3.47282982677729 0.00065037788670191 yes 52 0.000257500892035758 15 905973
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.45741021371572 0.000683466455963505 yes 53 0.000272696974841883 41 6312947
SGTC_91 0417-1751 58.384 µM 3.45336949733196 0.000692390481868744 yes 54 0.000276815053297397 68 6795624
SGTC_1044 1222-0021 1.78 µM 3.40354466535359 0.000811622728272773 yes 55 0.000332587684818719 55 4306703
SGTC_3110 9122132 49.47 µM 3.39586237918476 0.000831604337781214 yes 56 0.000342063737727628 28 918317
SGTC_93 0109-0045 59.227 µM 3.36041015266184 0.000929812395796946 yes 57 0.000389134198806766 69 88733
SGTC_3269 9137823 49.47 µM 3.33204661711664 0.00101593658098382 no 58 0.000431049069894722 35 17682936
SGTC_1420 4'-methoxyflavone 42 µM 3.32248536628325 0.0010465796153238 no 59 0.000446096755128239 27 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2345 9052315 157.45 µM 3.29653537961714 0.00113406941342187 no 60 0.000489426425275031 46 6469265
SGTC_2616 abietic acid 100 µM 3.25392162638114 0.00129238313768766 no 61 0.000569118387649352 55 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1153 4055-0057 267 µM 3.24042274697757 0.00134659702727507 no 62 0.000596763039264024 61 882706
SGTC_910 3454-3003 490 µM 3.22233480872552 0.00142250008327336 no 63 0.000635752305026899 44 820824
SGTC_2378 9074213 121.43 µM 3.21446070226394 0.00145674676708474 no 64 0.000653449012043815 52 657714
SGTC_2460 5552655 174.22 µM 3.19034289642496 0.00156637687498523 no 65 0.000710520394086988 62 5401989
SGTC_77 0828-0286 12.516 µM 3.18515480479991 0.00159092151264729 no 66 0.000723382964567945 74 745345
SGTC_913 3487-1245 167 µM 3.17771060133226 0.00162675231797687 no 67 0.000742214190705271 71 4016153
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 3.16714964183807 0.00167884690766493 no 68 0.000769705407556331 34 229346 A bile salt which induces apoptosis.
SGTC_674 0498-0004 451 µM 3.14971446555165 0.00176818340260469 no 69 0.000817150528770044 50 4231473
SGTC_1137 ixabepilone 100 µM 3.14737167486746 0.00178051181773819 no 70 0.000823727010235266 78 154225 A novel microtubule stabilizer.
SGTC_2854 9024559 71.43 µM 3.14218812799188 0.0018080674471144 no 71 0.000838451262243995 61 3163529
SGTC_1013 4112-3890 241 µM 3.10628788949191 0.0020098058540427 no 72 0.000947260856063528 77 705171
SGTC_2610 ononetin 44.17 µM 3.0929502177653 0.00208981827576611 no 73 0.000990886882084642 89 259632
SGTC_2975 9084847 53.72 µM 3.08322345877417 0.00214997927751013 no 74 0.00102385664881929 70 27211724
SGTC_2998 9066762 71.4286 µM 3.08219771025611 0.00215641431468717 no 75 0.00102739155745084 67 4945196
SGTC_2688 kanamycin b 96.69 µM 3.08137559169311 0.00216158448041805 no 76 0.00103023280106012 520 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_31 0508-1974 57.237 µM 3.04357664668047 0.0024117831187589 no 77 0.00116891939424663 66 6810525
SGTC_3 0833-0587 95.581 µM 3.04131044639477 0.00242758492047706 no 78 0.00117775413437664 55 5382644
SGTC_2087 5276107 200 µM 3.01061416411948 0.00265104788188502 no 79 0.00130359958240549 69 144405
SGTC_1268 0828-0275 2.46 µM 2.9282122610015 0.00334565442492819 no 80 0.00170458609438599 72 745337
SGTC_1271 0832-2808 169 µM 2.92406151046159 0.00338462349182102 no 81 0.00172748233675287 50 3663794
SGTC_249 wiskostatin 11.211 µM 2.92254230886095 0.00339898808618843 no 82 0.00173593224326807 54 2775510 A n-wasp and actin depolymerizer.
SGTC_1669 st015249 58.4 µM 2.91655416875364 0.00345614314818685 no 83 0.00176960630608708 35 722793
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.88244389970377 0.00379849120924241 no 84 0.00197301697804296 76 279621
SGTC_2516 gossypol 71.55 µM 2.88054923164435 0.00381836917515996 no 85 0.00198491473945491 68 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_109 0132-0036 33.701 µM 2.84392693032357 0.00422135973315253 no 86 0.00222806329169333 55 67274 A color developer.
SGTC_1221 2958-7315 257 µM 2.8436466516186 0.00422458531036952 no 87 0.00223002395789975 56 4562705
SGTC_2433 5607874 27.82 µM 2.84165521611567 0.00424756721230805 no 88 0.00224399995669783 82 2252428
SGTC_1373 2887-0003 58.5 µM 2.83686370802585 0.00430332170469721 no 89 0.00227795276459507 78 776948
SGTC_432 NS 1619 61.3 µM 2.83492343199716 0.00432608443222131 no 90 0.00229183349985098 83 4552 A K+/calcium channel activator.
SGTC_3317 9138495 8.753 µM 2.82877911601073 0.00439887936314843 no 91 0.00233629681155211 84 17020139
SGTC_342 k048-0088 23.3 µM 2.8277259220412 0.00441146639673339 no 92 0.00234399618023555 63 6820570
SGTC_1704 st028805 70.8 µM 2.82761351524229 0.00441281170233622 no 93 0.00234481928472534 51 2876101
SGTC_959 1222-0044 107 µM 2.80965443289914 0.0046325148285789 no 94 0.00247973595050004 80 6083612
SGTC_385 1494-0393 12.4 µM 2.79638900409699 0.00480101238924189 no 95 0.0025838579159323 94 3090647
SGTC_129 0088-0017 176.636 µM 2.78991555372447 0.00488520517859515 no 96 0.00263608953545966 130 182446
SGTC_1625 st003711 30.1 µM 2.75273934327036 0.00539467842552115 no 97 0.00295494646902498 112 24207034 YER133W GLC7
SGTC_450 aminopyrene 156 nM 2.74860015061346 0.00545422860835414 no 98 0.00299251738212363 106 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2315 7733312 200 µM 2.74061773711862 0.00557072273604052 no 99 0.00306619033714438 82 726316
SGTC_2679 rapamycin 1 nM 2.71922116189685 0.00589395394967242 no 100 0.00327179199487817 258 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1982 st072467 71.9 µM 2.70802924108789 0.0060695655472565 no 101 0.00338420293369888 125 3163533
SGTC_398 bronopol 33.3 µM 2.70391579558042 0.00613526535923875 no 102 0.00342638261285168 90 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2149 5554786 194.827 µM 2.7027847901097 0.00615343982511337 no 103 0.00343806255136672 119 745063 YPR165W RHO1
SGTC_2797 7859098 81.82 µM 2.68827729116552 0.0063908301921298 no 104 0.0035910863692799 106 972681
SGTC_2607 solasodine 47.35 µM 2.68552023056023 0.00643685029046836 no 105 0.00362084952829957 134 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2636 apigenin dimethyl ether 100 µM 2.67751211828648 0.00657218641348119 no 106 0.00370855847004468 138 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_660 4031-1742 102 µM 2.67699660957511 0.0065809840267787 no 107 0.0037142693337418 135 6738706
SGTC_2376 9072922 81.32 µM 2.67182610181738 0.00666980096510986 no 108 0.00377198660431551 123 17087968
SGTC_661 1304-0007 33.6 µM 2.66276733414218 0.00682796549586833 no 109 0.0038750490274042 82 3117130
SGTC_2003 4023581 200 µM 2.60782472058784 0.00786014523860303 no 110 0.00455597998300282 114 16641307
SGTC_2133 5320837 200 µM 2.60677773955322 0.00788108000564533 no 111 0.00456993331002622 103 2841355
SGTC_2203 7227154 166.4 µM 2.59767557827383 0.00806515724224464 no 112 0.00469285614072792 68 896304
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.59691587719266 0.00808069054760569 no 113 0.00470324791022153 107 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1216 1165-0504 9.65 µM 2.58306267321898 0.00836858901588563 no 114 0.00489637659070955 86 6304004
SGTC_1005 4092-0690 4.4 µM 2.57784463152751 0.00847934333336067 no 115 0.00497093440209314 113 1529343
SGTC_3056 9094900 49.47 µM 2.56467976643 0.00876450624104259 no 116 0.00516355340604397 110 25236784
SGTC_84 0443-0269 128.823 µM 2.56006044170893 0.00886653911272191 no 117 0.00523269800502625 105 6150058
SGTC_779 1360-0071 233 µM 2.55950336740154 0.00887891398210759 no 118 0.00524109201603673 130 7566
SGTC_71 0417-1750 47.813 µM 2.55533936760132 0.00897189356433873 no 119 0.00530421562339854 150 6811472
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.54858234491484 0.00912458930813941 no 120 0.00540808742779474 103 165521
SGTC_396 dithiazanine 1.25 µM 2.53999218935731 0.00932199195935712 no 121 0.00554274722408767 61 10578 An antihelmenthic.
SGTC_3113 9123498 49.47 µM 2.53366099672869 0.00946986553378303 no 122 0.00564389371485754 76 8897275
SGTC_1884 5633444 25 µM 2.5310152732774 0.00953226514587354 no 123 0.00568664480322428 151 5724239
SGTC_212 3807-4682 38.772 µM 2.52911860223038 0.00957721923148072 no 124 0.00571746895309883 201 3125501 YBL034C STU1
SGTC_666 0272-0154 136 µM 2.52767041389053 0.00961166823402697 no 125 0.00574110424884657 167 6870312
SGTC_3169 9102970 49.47 µM 2.52640226074333 0.00964192351551197 no 126 0.00576187243717926 58 17027839
SGTC_3094 9117742 49.47 µM 2.52480650290319 0.00968011294326762 no 127 0.00578810043155612 127 17149698
SGTC_1038 k292-0204 154 µM 2.52407500385284 0.00969766320109438 no 128 0.00580015877654153 94 4454212
SGTC_1501 4491-0275 38.4 µM 2.50837942320374 0.0100809904517935 no 129 0.00606431771448884 76 5104718
SGTC_1008 4106-0037 6 µM 2.50003086574365 0.0102902209854037 no 130 0.00620912432261989 89 2905394
SGTC_1646 st011709 75.6 µM 2.47556035604139 0.0109254616863065 no 131 0.00665136374467803 86 5757843
SGTC_625 k213-0058 121 µM 2.47199252731587 0.0110208744136069 no 132 0.00671811624336408 289 3655420
SGTC_1627 st003713 25.6 µM 2.46650921042925 0.0111689250830517 no 133 0.00682186097660326 240 16195070 YER133W GLC7
SGTC_1377 2944-0135 198 µM 2.4663958314489 0.0111720044986992 no 134 0.00682402096633127 156 1894137
SGTC_319 1348-1596 45.5 µM 2.46089878312394 0.0113221946236883 no 135 0.00692947291447213 115 5380505
SGTC_2120 5538279 151.968 µM 2.45400141694528 0.011513123869955 no 136 0.00706382123882785 113 2058197
SGTC_2962 9082311 13.18 µM 2.44964990518612 0.0116350134919845 no 137 0.00714975866933099 122 16459453
SGTC_2984 9022109 38.96 µM 2.44679325117149 0.0117156386380507 no 138 0.00720667458476111 77 6459207
SGTC_1664 st014217 9.02 µM 2.44673812581326 0.0117171992330229 no 139 0.00720777681997701 102 3982782
SGTC_1896 st058441 89 µM 2.43756582857869 0.0119793918853018 no 140 0.00739326084844831 103 688759
SGTC_203 k066-0004 30.888 µM 2.43741694839164 0.011983689295469 no 141 0.00739630591027605 140 6795412
SGTC_2381 9035592 200 µM 2.43563881096431 0.01203511846367 no 142 0.00743275985841754 120 4749657
SGTC_998 3996-0085 177 µM 2.43191494799753 0.0121434443618141 no 143 0.00750961683151238 125 715391
SGTC_1944 st076371 56.9 µM 2.4155461790496 0.0126296875149177 no 144 0.0078558150260506 147 24208455
SGTC_1685 st024049 53.0905 µM 2.40807512422785 0.0128571628463646 no 145 0.00801844033480877 103 1941139
SGTC_586 0957-0265 8.15 µM 2.40149707152379 0.0130603734979111 no 146 0.0081640698807909 110 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_149 3970-0822 46.1 µM 2.40084328954698 0.0130807211338423 no 147 0.00817866995133965 274 3114250 YBL034C STU1
SGTC_440 fluspirilene 35.1 µM 2.37417628971746 0.0139343590183641 no 148 0.00879407541859349 148 3396 An atypical antipsychotic.
SGTC_2270 7924575 90.91 µM 2.37138152829357 0.0140265426657307 no 149 0.00886086353201324 132 1262135
SGTC_2236 dapsone 200 µM 2.36689220512125 0.01417572083346 no 150 0.00896907829752021 121 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1997 st073024 93.8 µM 2.353618525666 0.0146248209004094 no 151 0.00929583984488422 97 686268
SGTC_918 glabranin 770.725 nM 2.35144644217865 0.0146994645331375 no 152 0.00935029077507026 152 124049 Also referred to as licorice root.
SGTC_1237 0330-0133 46.1 µM 2.35123665397207 0.0147066912288043 no 153 0.00935556460277687 126 X1237 YHR072W ERG7
SGTC_457 grayanotoxin iii 135 µM 2.34956589432646 0.0147643540262865 no 154 0.00939765849270739 238 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1064 honokiol 6.76 µM 2.34952184571501 0.0147658768998887 no 155 0.00939877051150323 152 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_909 3448-9333 149 µM 2.34736890142795 0.0148404745715562 no 156 0.00945326263251553 116 3344074
SGTC_744 1594-0068 283 µM 2.34522084210164 0.0149152257342435 no 157 0.0095079062596177 176 668392
SGTC_1518 st038567 90.8 µM 2.33519597263517 0.0152683805989351 no 158 0.00976659271936733 115 77966
SGTC_2184 6075246 200 µM 2.33513421837931 0.0152705781374725 no 159 0.00976820512355566 130 2267320
SGTC_1661 st013063 9.66 µM 2.33001122264862 0.0154538295811598 no 160 0.00990277898788068 164 721395
SGTC_2440 5628896 157.78 µM 2.32988240691309 0.0154584615937783 no 161 0.00990618355692662 116 5522048
SGTC_784 4579-0127 173 µM 2.32709057194283 0.0155591448459205 no 162 0.00998022260207474 133 1948547
SGTC_524 r073-0010 27.8 µM 2.31831628392837 0.0158792479764829 no 163 0.010216069030219 171 2772106
SGTC_161 4065-0411 162.148 µM 2.31683758638259 0.0159337460329688 no 164 0.0102562903574273 222 1906281 YLR208W SEC13
SGTC_2144 5628481 200 µM 2.30840936111903 0.0162474432926384 no 165 0.0104881894134074 135 2818399
SGTC_2505 galangin 7.89 µM 2.29724387920833 0.0166711559478609 no 166 0.0108024306383356 97 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.29616650636669 0.0167125362810293 no 167 0.0108331814104969 204 140250 A respiratory chain inhibitor.
SGTC_256 clotrimazole 625 nM 2.29218613606366 0.01686617944202 no 168 0.0109474523075737 180 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_971 1315-0384 26.7 µM 2.29054255181035 0.0169299736335863 no 169 0.0109949424101835 166 6769120
SGTC_2920 7982904 15.77 µM 2.29005754955766 0.0169488379223094 no 170 0.0110089903799253 145 6456808
SGTC_781 4335-2806 94.4 µM 2.28710600090591 0.017064027070925 no 171 0.0110948183557836 152 845254
SGTC_893 0958-0369 48.9 µM 2.27574930370721 0.0175135023089265 no 172 0.0114305092932103 180 6819948
SGTC_52 0329-0193 875 nM 2.27131222883878 0.0176918387018592 no 173 0.0115640417324591 162 3739292
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.26427619802429 0.017977809520349 no 174 0.0117785662860164 243 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2714 st079313 56.9 µM 2.25130202898797 0.0185154697261257 no 175 0.0121832071943966 129 2939799
SGTC_3175 9106517 49.47 µM 2.25084821786907 0.0185345212444815 no 176 0.0121975761924079 127 41468073
SGTC_864 0469-0573 172 µM 2.2473372145468 0.0186824821278327 no 177 0.012309242122918 138 689425
SGTC_95 0471-0001 561.058 µM 2.24560732358204 0.0187557522181595 no 178 0.0123645854892708 168 4015405
SGTC_1193 1488-0126 41.5 µM 2.24071705979741 0.0189642049537629 no 179 0.0125222041695071 173 1384710
SGTC_981 1488-1094 54.9 µM 2.2378910607287 0.0190855621727653 no 180 0.0126140800645275 113 3449522
SGTC_286 k060-0067 22.9 µM 2.23730720724117 0.0191107167987473 no 181 0.0126331342474857 155 5985051
SGTC_1883 5-benzylidenerhodanine 20 µM 2.23055939169313 0.0194034895781145 no 182 0.0128551646128062 242 1273210
SGTC_688 0527-0193 473 µM 2.22763600241021 0.0195315071145006 no 183 0.0129523989141854 120 4007154
SGTC_3218 9131285 49.47 µM 2.21071426146896 0.0202866997343928 no 184 0.0135278151568158 233 17156417
SGTC_2484 5809818 12.04 µM 2.20468430268343 0.0205617239858541 no 185 0.0137381277011435 153 2870548
SGTC_35 0133-0054 64.071 µM 2.20432258059659 0.0205783219432653 no 186 0.0137508330106415 161 99677
SGTC_2743 auranofin 4.32 µM 2.20363280707365 0.0206100043080523 no 187 0.0137750890594552 164 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_757 1066-0008 322 µM 2.20275440774159 0.0206504103510297 no 188 0.0138060315972593 171 6842497
SGTC_643 k048-0106 28.4 µM 2.19920045900502 0.0208145762340148 no 189 0.0139318358618297 136 6763920
SGTC_2420 aureobasidin a 50 nM 2.18820911246446 0.0213293035914476 no 190 0.0143271868221257 225 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_530 4358-1714 28 µM 2.18211627505825 0.0216192412103421 no 191 0.0145504761737304 211 1564641
SGTC_2140 5586273 200 µM 2.18011410262089 0.0217152419402451 no 192 0.0146245023267234 116 854421
SGTC_2455 5377712 9.75 µM 2.17842779268385 0.0217963767669375 no 193 0.0146871013033931 164 2243908
SGTC_1991 st073000 8.92 µM 2.1771222177374 0.0218593687016437 no 194 0.0147357248805852 258 4301969 YIL048W NEO1
SGTC_481 bay k-8644 50 µM 2.17132063354746 0.0221411486189819 no 195 0.0149534718255355 170 2303 A calcium channel antagonist.
SGTC_2725 haloperidol 53.21 µM 2.16578531821129 0.0224128475889102 no 196 0.0151637978877936 202 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_22 0964-0034 14.468 µM 2.16360944566381 0.0225204167714219 no 197 0.0152471679976862 225 138402
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.15982035743518 0.0227087780047661 no 198 0.0153932895320336 121 616764
SGTC_3055 9094636 49.47 µM 2.15765738181373 0.0228168968586466 no 199 0.0154772398844843 156 25236176
SGTC_627 1391-0720 175 µM 2.14172958373364 0.0236264986525807 no 200 0.0161076243385133 166 997839
SGTC_2865 9030313 51.95 µM 2.14159540496773 0.0236334202011254 no 201 0.0161130269115829 135 42562754
SGTC_3288 9119690 36.221 µM 2.13841747223083 0.0237978515283864 no 202 0.0162414378241044 164 17595618 YKL019W RAM2
SGTC_2039 Aminomethylbenzodioxan 200 µM 2.13353962765877 0.0240521094722276 no 203 0.0164402422447912 131 15053
SGTC_735 3076-0345 636 µM 2.12085290280376 0.024724113321377 no 204 0.0169670915554023 223 2888990
SGTC_590 k048-0076 22.4 µM 2.11770248434385 0.0248934079792899 no 205 0.0171001361682339 164 6832814
SGTC_3184 9108758 49.47 µM 2.11111413310931 0.0252505910173088 no 206 0.0173812514667203 136 902885
SGTC_132 0417-1715 25.805 µM 2.11079975134723 0.0252677418114334 no 207 0.0173947637605526 176 6769098
SGTC_47 0149-0135 24.25 µM 2.10944085098376 0.0253419876272067 no 208 0.0174532732518307 184 5239155
SGTC_574 1315-0397 40 µM 2.10767310156099 0.0254388450334217 no 209 0.0175296377693829 244 6794277
SGTC_1788 fluconazole 20 µM 2.10431734979996 0.025623564273497 no 210 0.0176753868080566 229 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3109 9122853 49.47 µM 2.10172938681975 0.0257667859260487 no 211 0.0177884939048652 153 1234709
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.10064186964779 0.0258271703281102 no 212 0.0178362078480952 159 6857784
SGTC_908 3448-7491 47.7 µM 2.10018547624101 0.0258525468294199 no 213 0.0178562642393621 350 1203031
SGTC_1819 st053448 58.6 µM 2.09445960883875 0.026172694652042 no 214 0.0181095287690144 178 2857616
SGTC_1955 wogonin 32.4 µM 2.09186089361508 0.0263190854349379 no 215 0.0182254806118268 167 5281703 A flavanone.
SGTC_3070 9117005 49.47 µM 2.08648858867172 0.0266238886860323 no 216 0.0184671939050034 115 8779016
SGTC_2356 9061756 188.97 µM 2.07207937303638 0.0274560007065894 no 217 0.0191290198089942 141 20104043
SGTC_3117 9124945 49.47 µM 2.07145544147488 0.0274925162762123 no 218 0.0191581271994818 149 17592065
SGTC_2312 7706453 155.7 µM 2.06791573787499 0.0277004445358055 no 219 0.0193239736286649 216 976098
SGTC_2653 dihydrofissinolide 100 µM 2.06708072334219 0.0277496853004538 no 220 0.0193632740886946 132 6857746
SGTC_3181 9108277 49.47 µM 2.0656172952089 0.0278361595076185 no 221 0.0194323150274105 190 17097298
SGTC_962 1254-0300 21.5 µM 2.04564484643097 0.0290389414945661 no 222 0.0203956628849472 178 7340576
SGTC_278 4092-0821 23.9 µM 2.03850905337218 0.0294790127871134 no 223 0.0207495251416757 213 877900
SGTC_1900 st060200 72.8 µM 2.03736802964972 0.029549891649707 no 224 0.0208065875772288 190 688945
SGTC_1482 3346-2049 8.48 µM 2.03607337987868 0.0296304848039897 no 225 0.0208714936741448 196 3826804
SGTC_948 3448-0295 75.3 µM 2.03568896727092 0.029654449940729 no 226 0.0208907988238574 241 678569
SGTC_1415 3966-0071 78.1 µM 2.03379633018482 0.029772675813483 no 227 0.0209860673534414 161 2893185
SGTC_2945 9067681 61.76 µM 2.03309965959518 0.0298162925354212 no 228 0.0210212276969827 166 16456930
SGTC_1904 st060225 78 µM 2.02801163284818 0.0301364503837788 no 229 0.0212795303784649 177 66595
SGTC_3324 9138759 60.749 µM 2.02581891178576 0.0302753007556533 no 230 0.0213916725970699 196 45595710
SGTC_2200 6600604 21.907 µM 2.02350337269547 0.0304225035188002 no 231 0.0215106381043756 247 2904777
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.02182424718724 0.0305296188913888 no 232 0.0215972559437695 226 6708784 An antioxidant flavonoid
SGTC_145 3737-0113 38.366 µM 2.02164825559983 0.0305408638746103 no 233 0.0216063515269489 301 6849351
SGTC_1772 st048439 82.2 µM 2.02024160343511 0.030630865269195 no 234 0.0216791664066538 256 2927068 YDL195W SEC31
SGTC_2489 cantharidin 73.42 µM 2.01751977086794 0.0308056391658441 no 235 0.0218206499589512 267 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1409 3909-8004 61.9 µM 2.00594787602138 0.0315579323237919 no 236 0.0224309047491544 265 2119279
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.99966681478335 0.031972583874289 no 237 0.0227681269347188 226 5282362
SGTC_882 0843-0131 351 µM 1.99900064687323 0.0320168244246258 no 238 0.0228041419374676 218 5425421
SGTC_879 0831-1030 162 µM 1.99711003461326 0.0321426563196192 no 239 0.022906615551644 297 1549252
SGTC_676 falcarinol 140 µM 1.99607562245686 0.0322116754365369 no 240 0.0229628460181114 251 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_355 1311-2252 105 µM 1.98579895022765 0.0329040330700957 no 241 0.0235278261937636 242 5338538
SGTC_377 3970-0964 33.1 µM 1.9821327574908 0.0331539804594575 no 242 0.0237321920616794 333 16481235
SGTC_1364 1653-0028 37.6 µM 1.97983170382128 0.0333116551829956 no 243 0.0238612213251256 235 5718652
SGTC_2173 5763948 167 µM 1.97830328820784 0.0334167274920986 no 244 0.0239472511988539 211 2867177
SGTC_650 1328-0195 38 µM 1.97347203595457 0.0337506521807128 no 245 0.0242209037508539 248 2780821
SGTC_889 0919-1524 82.7 µM 1.97052205799242 0.0339558943088879 no 246 0.0243892847588746 210 3905452
SGTC_3120 9124077 49.47 µM 1.96827279161292 0.0341130738384411 no 247 0.0245183293940536 183 18774327 YGL155W CDC43
SGTC_2669 eugenol 100 µM 1.96357337227717 0.0344434017698474 no 248 0.0247897939428241 153 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_313 3474-0040 5.03 µM 1.9583620403224 0.0348127811790178 no 249 0.0250937728362849 322 1043375 YIL048W NEO1
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.95625521589631 0.0349630333023684 no 250 0.0252175484722146 245 5282309
SGTC_3021 9087658 49.47 µM 1.95582160234082 0.0349940232169202 no 251 0.0252430865879852 155 25237042
SGTC_1139 k015-0024 46.9 µM 1.95556685024189 0.035012240597971 no 252 0.0252581005779733 181 2766652
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.94041232239587 0.0361100271536815 no 253 0.0261648001191937 233 6708760
SGTC_3099 9120367 49.47 µM 1.93737390351859 0.0363334861334622 no 254 0.026349827131967 211 24824940
SGTC_311 1315-0136 58 µM 1.93546551062826 0.0364744157418081 no 255 0.0264665985102322 203 6759207
SGTC_196 k015-0023 18.111 µM 1.92791651093187 0.0370362794118791 no 256 0.0269327558493976 244 5211998
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.92535172388776 0.0372287762246983 no 257 0.0270926854031675 219 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1012 4112-3522 18 µM 1.91915227203403 0.0376974456446534 no 258 0.0274825328759507 257 3112398
SGTC_1600 coumarin 106 71.1 µM 1.91872726511144 0.0377297511614578 no 259 0.0275094295335621 259 100336 A hepatotoxic, DNA x-linker.
SGTC_2409 alverine citrate 63.97 µM 1.91407977156183 0.0380844919859168 no 260 0.0278049818843447 286 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2434 5670830 169.91 µM 1.91043347364285 0.0383647126262474 no 261 0.028038712188964 273 1549830
SGTC_603 3794-0023 45.9 µM 1.90941054100034 0.0384436269583619 no 262 0.0281045760213997 208 3802260
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.90886537922245 0.0384857375831937 no 263 0.0281397300848585 262 688664
SGTC_1822 st052468 42 µM 1.90502962418724 0.0387830916237395 no 264 0.0283881101938799 206 2873678
SGTC_300 r073-0011 5.04 µM 1.90082237213924 0.0391113940210265 no 265 0.0286626413390879 280 2735780
SGTC_1641 st009299 47.1 µM 1.8994099144754 0.0392221175469914 no 266 0.0287553004694636 168 4046054
SGTC_2614 arthonioic acid 13.39 µM 1.8986103814453 0.0392849064802567 no 267 0.0288078612177065 230 6710684
SGTC_2730 imipramine 71.33 µM 1.89857583800258 0.0392876210883905 no 268 0.0288101338785205 320 3696 A tricyclic antidepressant.
SGTC_2005 4024620 188 µM 1.89635729582061 0.0394622859480538 no 269 0.0289564073406675 229 236743
SGTC_516 3992-2719 87.3 µM 1.89360960491022 0.0396794855559423 no 270 0.0291384238351983 231 5350887 YDR037W KRS1
SGTC_2322 7413319 38.22 µM 1.88948468511673 0.0400073765004256 no 271 0.0294134564935126 462 1840400
SGTC_966 1300-0360 30.2 µM 1.88701593821363 0.0402046687992873 no 272 0.0295790909801229 267 70588
SGTC_1565 sinapyl alcohol 95.1 µM 1.88573355845853 0.0403074628825404 no 273 0.0296654341420234 263 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2647 atorvastatin 60.16 µM 1.88391005221275 0.0404540004928557 no 274 0.029788571644454 239 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3033 9090887 49.47 µM 1.88282577097914 0.0405413385845501 no 275 0.029861991678024 285 19325384
SGTC_2852 9023854 51.95 µM 1.87593221643977 0.0411001957343104 no 276 0.0303322940858349 255 19798528
SGTC_549 1661-1316 519 µM 1.8741424151148 0.0412463110696506 no 277 0.0304553992810919 263 2857282
SGTC_3331 9141060 1.957 µM 1.87194049091812 0.041426648599983 no 278 0.0306074184650433 245 4906567 YPR165W RHO1
SGTC_1862 st057513 3.81 µM 1.87150979949066 0.0414619968205012 no 279 0.0306372264367498 229 5393163
SGTC_2950 9072895 21.46 µM 1.86229016129888 0.0422245609645469 no 280 0.0312811007715602 337 17332245
SGTC_441 propafenone 146 µM 1.85534364970566 0.0428065769821603 no 281 0.031773584362708 200 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2824 7998404 51.95 µM 1.85281431256002 0.043020102007479 no 282 0.0319544890371627 247 837851
SGTC_2115 tiliquinol 12.7705 µM 1.85200965446727 0.0430882108692385 no 283 0.0320122182833679 216 71208 A bioactive hydroxyquinoline.
SGTC_1550 gossypolone 36.6 µM 1.84952303626503 0.0432992369402778 no 284 0.0321911622951737 290 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2979 9012552 45.46 µM 1.84808174845582 0.0434219329221926 no 285 0.0322952588455995 198 17100905
SGTC_728 3030-5151 22.5 µM 1.84427512080244 0.0437473388846043 no 286 0.0325715276886001 239 3125388
SGTC_2502 avocadyne acetate 18.59 µM 1.84346152408745 0.0438171429903146 no 287 0.0326308272046445 318 3952079
SGTC_285 1486-1325 46 µM 1.83948983282235 0.0441591928405569 no 288 0.0329215859866153 278 22310230
SGTC_362 0310-0100 9.03 µM 1.8355833542524 0.0444977230935948 no 289 0.0332096504358944 293 790235
SGTC_182 3448-4371 550.524 µM 1.8347619613887 0.0445691692677856 no 290 0.0332704835149764 293 3491403
SGTC_2785 7756463 72.73 µM 1.83406594432394 0.044629782339187 no 291 0.0333221029586908 270 2201551
SGTC_2241 6772625 37.8075 µM 1.82761781393408 0.0451944839383267 no 292 0.0338034651840566 269 2285411
SGTC_496 calpeptin 138 µM 1.8260878781151 0.0453293099885712 no 293 0.0339185129156253 252 73364 A calpain inhibitor.
SGTC_263 alizarin 107.927 µM 1.82228894987714 0.0456654910319425 no 294 0.0342055769895381 375 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2622 2-methoxyxanthone 59.94 µM 1.81929322173376 0.0459320049674637 no 295 0.0344333534802256 257 71034 A hepatoprotective.
SGTC_856 0433-0016 11.3 µM 1.81826142182354 0.0460240875242762 no 296 0.0345120930749003 279 3911780
SGTC_1357 1503-1303 39.5 µM 1.81617570759531 0.0462106790888782 no 297 0.0346717116173809 317 292895
SGTC_2387 9077560 195.08 µM 1.81017002577516 0.0467513524844274 no 298 0.0351347121722838 290 5303272
SGTC_1331 1472-0049 76.2 µM 1.80893917932704 0.0468627860674846 no 299 0.0352302263850755 296 24051409
SGTC_2293 7624732 200 µM 1.80779801330244 0.0469662907375718 no 300 0.0353189715500012 267 894453
SGTC_1266 0828-0227 32.9 µM 1.80742038143592 0.0470005825923069 no 301 0.0353483792280406 274 3913820
SGTC_3198 9112019 49.47 µM 1.8055083439914 0.0471745184721133 no 302 0.0354975855026722 255 45595555
SGTC_761 k216-0224 480 µM 1.80088054182605 0.0475976405359604 no 303 0.0358608552691289 287 1340404
SGTC_576 1073-0113 22.7 µM 1.79534952173398 0.0481073259392745 no 304 0.0362990147791777 433 5439563
SGTC_3232 9132874 49.47 µM 1.79521117125822 0.0481201307541861 no 305 0.0363100306369717 253 3784940
SGTC_3304 9125678 46.087 µM 1.79238762640009 0.0483820558963623 no 306 0.0365354477402212 321 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1922 5578187 25 µM 1.79076737510187 0.0485328720856556 no 307 0.0366653163540403 308 1350412
SGTC_2657 nystatin 74.44 µM 1.78974926968912 0.0486278315029768 no 308 0.0367471139514941 289 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2082 5219693 150 µM 1.78395791963974 0.0491708237031853 no 309 0.0372152515934498 312 2834649
SGTC_3187 9109394 49.47 µM 1.78195051272101 0.0493601627331877 no 310 0.0373786510803271 310 17098090
SGTC_1228 0124-0032 52.5 µM 1.77886236703005 0.0496525732605338 no 311 0.0376311646208663 307 X1228
SGTC_2821 7996764 71.43 µM 1.7710197465566 0.0504013902793653 no 312 0.0382787090462315 344 2987135
SGTC_423 5-fluorouracil 457 µM 1.76065247481187 0.0514050411863796 no 313 0.0391486205991802 313 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_14 0354-0009 295 µM 1.74945440729954 0.0525069112531758 no 314 0.0401062516160046 312 1713507
SGTC_2141 5621638 7.665 µM 1.74475859873217 0.0529745140219173 no 315 0.0405134491387823 281 2856238
SGTC_469 w7 172 µM 1.74420307567031 0.0530300501010748 no 316 0.0405618426104203 204 45115570 A P450 inhibitor.
SGTC_420 mitomycin C 81.9 mM 1.74328154352327 0.0531222782070529 no 317 0.040642223831474 325 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1497 4476-2978 41.3 µM 1.73869264749931 0.0535834356314413 no 318 0.0410444200084268 359 1528379
SGTC_1105 epirubicin 18.1 µM 1.73570398653249 0.0538854801973724 no 319 0.0413080941293862 301 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3158 9100007 49.47 µM 1.73054804868094 0.0544097246344833 no 320 0.0417662021916733 263 19297233
SGTC_223 busulfan 5 mM 1.72828520536445 0.0546410757520445 no 321 0.0419685520887734 214 2478 A DNA alkylator.
SGTC_1148 3909-7663 27.7 µM 1.72714100054926 0.0547583539714395 no 322 0.0420711718462492 308 4084526
SGTC_395 anisomycin 6.25 µM 1.72056897388924 0.0554358291908012 no 323 0.042664533771677 247 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2043 5101342 149 µM 1.71983508457285 0.0555118909183738 no 324 0.0427312115822302 322 678451
SGTC_3150 9097574 49.47 µM 1.71344756648793 0.0561773897969204 no 325 0.0433151158953589 254 17217476
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.70836558314313 0.0567113489099025 no 326 0.0437842645942373 329 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1065 prochlorperazine maleate 2.48 µM 1.7075952601905 0.0567926337924843 no 327 0.0438557342382095 349 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1825 st052143 62.6 µM 1.70250310849123 0.0573322707429286 no 328 0.0443305481287003 262 674173
SGTC_1611 st001856 99.4 µM 1.70193697171633 0.0573925150512302 no 329 0.0443835920704913 315 647478
SGTC_605 1315-0399 119 µM 1.70067721518882 0.0575267482287692 no 330 0.0445018079485502 360 24020461
SGTC_17 0960-0276 49.807 µM 1.70066223776258 0.0575283456304828 no 331 0.0445032149585112 369 6821114
SGTC_1735 st034310 56.75 µM 1.70004326407255 0.0575943921424025 no 332 0.044561393962067 323 871153
SGTC_2883 9059145 45.46 µM 1.69979154773247 0.0576212681483783 no 333 0.0445850709759046 279 16476510
SGTC_1489 4065-0444 182 µM 1.69095890796899 0.0585705981481028 no 334 0.0454223255548699 291 2877968
SGTC_3275 9138069 49.47 µM 1.68955242117295 0.0587228939872327 no 335 0.0455568074732439 291 17617007
SGTC_780 0109-0199 192 µM 1.68847552161192 0.0588397117451831 no 336 0.0456599919964897 367 610414
SGTC_1444 4112-3581 28 µM 1.68522982678531 0.0591928950270845 no 337 0.0459721192701589 312 2877249
SGTC_2900 5328528 85.29 µM 1.6803944419286 0.0597221427311568 no 338 0.0464402983698831 381 795359
SGTC_3208 9114115 49.47 µM 1.67621766514542 0.0601822819009094 no 339 0.0468477826299135 354 650895
SGTC_2167 5876490 200 µM 1.67370098195801 0.060460872148631 no 340 0.0470946903573211 349 686534
SGTC_867 0518-0118 155 µM 1.67165311768631 0.0606883091528171 no 341 0.0472963719610761 334 6848158
SGTC_3197 9113331 49.47 µM 1.66914771307831 0.060967470362049 no 342 0.0475440547082095 370 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_904 1141-0088 396 µM 1.66739576444083 0.0611632744926639 no 343 0.0477178677679271 324 1378119
SGTC_3141 9094609 49.47 µM 1.65858268596531 0.062155719485652 no 344 0.0485999565284882 352 25236309 YDL196W YDL196W
SGTC_1964 st076914 61 µM 1.6537831868775 0.0627014524486741 no 345 0.0490857866482431 307 24208661
SGTC_2662 daunorubicin 22.37 µM 1.64848913351147 0.0633077429019632 no 346 0.049626169371966 303 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_251 melphalan 456.522 µM 1.64500687776371 0.0637090228700344 no 347 0.0499841963713389 392 460612 A DNA alkylator.
SGTC_3058 9093861 49.47 µM 1.64396441680515 0.0638295355899002 no 348 0.0500917763464028 356 17217477
SGTC_687 k029-0044 34.9 µM 1.64090041010856 0.0641847737873406 no 349 0.050409044945504 348 5829338
SGTC_517 1365-0151 113 µM 1.63219773169137 0.0652021379974948 no 350 0.0513189192413308 344 768657
SGTC_1011 4112-3381 17.4 µM 1.62908602009254 0.0655689262148656 no 351 0.0516474051297946 367 2877139
SGTC_3344 9148862 3.898 µM 1.62554714080208 0.0659880083937824 no 352 0.0520230138905377 343 4905352
SGTC_2255 7941087 197.44 µM 1.6213762137317 0.0664846002974802 no 353 0.0524684894358546 400 935561
SGTC_150 3970-0969 77.2 µM 1.61259464957743 0.0675395892453128 no 354 0.0534163008310333 456 6615640
SGTC_20 0481-0013 4.944 µM 1.60992612999683 0.0678627262116839 no 355 0.0537069918905193 371 182045
SGTC_2552 juarezic acid 87.02 µM 1.60631888541934 0.0683014317273562 no 356 0.0541019314786518 434 1549512
SGTC_2013 4024628 200 µM 1.60135375799905 0.0689088554515314 no 357 0.054649294284994 374 5230760
SGTC_1467 k284-1082 293 µM 1.60060969472781 0.0690002403329165 no 358 0.0547316968307865 367 3334705
SGTC_641 4092-0595 30 µM 1.59695318398322 0.0694506862041585 no 359 0.0551380716409441 373 786260
SGTC_2285 7945142 200 µM 1.59559962440579 0.0696180044660277 no 360 0.0552891057246233 371 2970608
SGTC_1450 4112-4260 37.6 µM 1.59391103705167 0.0698271715666691 no 361 0.0554779810117768 378 1633175
SGTC_568 1193-0097 7.48 µM 1.59362949492638 0.0698620934829677 no 362 0.0555095221201806 459 3646150
SGTC_1242 0402-0103 60.1 µM 1.59255516610685 0.0699954745684774 no 363 0.0556300090578082 347 432868
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.59194762397633 0.0700709893935746 no 364 0.0556982367660372 361 16623 A steroid.
SGTC_1642 st009582 77.7 µM 1.5911455679824 0.0701707774065065 no 365 0.0557884097299815 331 6739311
SGTC_140 0062-0056 502.533 µM 1.58688827547992 0.0707022804542339 no 366 0.0562689754071254 423 3758964
SGTC_2912 7964298 10.93 µM 1.58434816021169 0.0710208723381753 no 367 0.0565572559311058 453 2975850
SGTC_2190 6049624 200 µM 1.58056805874883 0.0714970282703692 no 368 0.0569884169691637 307 2265554
SGTC_638 3970-0837 4.09 µM 1.57829847664156 0.071784088162981 no 369 0.0572485278653407 393 4118451 YLR208W SEC13
SGTC_1081 sertraline 6 µM 1.57772330340263 0.0718569770856557 no 370 0.0573145951431346 434 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_105 0111-0055 734.78 µM 1.5762498894325 0.0720439546383149 no 371 0.0574841125563558 309 5179370
SGTC_1001 4048-4355 44.4 µM 1.57515552201734 0.0721830720816138 no 372 0.0576102754406576 370 21824233
SGTC_610 4215-0184 155 µM 1.57357277509416 0.0723846370896097 no 373 0.0577931256995476 406 5605015
SGTC_747 3448-8087 38.7 µM 1.57304466094569 0.0724519890246328 no 374 0.0578542386484553 420 5168703
SGTC_2176 5809774 33.9695 µM 1.57170309565621 0.0726232986378951 no 375 0.0580097119633217 374 2870539
SGTC_791 1348-1292 225 µM 1.57088122979665 0.0727283989716066 no 376 0.058105119652225 469 5437054
SGTC_2098 5376439 882.5 nM 1.56836744419651 0.0730505852235295 no 377 0.0583977021514956 408 2844116
SGTC_2580 diallyl disulphide 81.36 µM 1.56363838307326 0.0736596571683786 no 378 0.0589512577660987 363 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3151 9099821 49.47 µM 1.56361924542827 0.0736621298341521 no 379 0.0589535062389874 339 17174189
SGTC_1135 dihydrocapsaicin 536.708 nM 1.55480882631632 0.0748072265915902 no 380 0.0599958032080554 409 107982 A Capsaicinoid.
SGTC_1053 3366-3204 134 µM 1.55269429033863 0.0750840648415105 no 381 0.0602480935183116 431 3632071 YPR165W RHO1
SGTC_1844 rapamycin 4 nM 1.55028074742348 0.0754010035539168 no 382 0.0605370731144256 558 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_878 0828-0289 13.7 µM 1.55022217143961 0.0754087082183938 no 383 0.0605441000201383 472 745350 YLR208W SEC13
SGTC_2830 7992007 71.43 µM 1.54909005584327 0.0755577364724647 no 384 0.0606800365217543 368 1952075
SGTC_2036 5160441 105 µM 1.54025777560887 0.0767281056481913 no 385 0.0617487658909027 481 134534 YIL048W NEO1
SGTC_3034 9090421 49.47 µM 1.53994842189344 0.0767693467137737 no 386 0.0617864631740663 348 17173761
SGTC_706 4262-0057 46.9 µM 1.53246447699888 0.0777722022230275 no 387 0.0627039285456677 405 883298
SGTC_1727 st034309 9.9045 µM 1.53190341141754 0.0778477843406127 no 388 0.0627731357844967 499 870305
SGTC_445 e6 berbamine 66 µM 1.52604195427877 0.0786407277699025 no 389 0.063499708203099 561 6610268 A calcium/calmodulin antagonist.
SGTC_823 0417-1665 178 µM 1.5234804125446 0.0789891715036603 no 390 0.0638192787622689 406 3429856
SGTC_855 0428-0020 25 µM 1.5177717686442 0.0797699174703019 no 391 0.0645359721908108 361 6812414
SGTC_194 1486-1323 56.904 µM 1.51632070801728 0.0799692999672297 no 392 0.0647191389465051 404 5178754
SGTC_2360 9040895 200 µM 1.5134353558218 0.0803668800745971 no 393 0.0650845549498652 395 4914414
SGTC_2699 st077704 54.6 µM 1.51187298470727 0.0805827856136324 no 394 0.0652830889101211 414 645852
SGTC_1750 st081859 2.357 µM 1.51107334923999 0.0806934573516785 no 395 0.0653848819663344 630 5291695
SGTC_731 3966-0296 387 µM 1.51053202294298 0.0807684435224801 no 396 0.0654538622926537 400 660956
SGTC_3023 9089636 49.47 µM 1.50768087244154 0.0811642621958352 no 397 0.0658181116354298 405 17249241
SGTC_3054 9094397 49.47 µM 1.50637727721934 0.0813457241830326 no 398 0.0659851752261146 451 2598354
SGTC_1165 k072-0275 30.3 µM 1.50379638368082 0.0817058900677142 no 399 0.0663169013117399 393 6153523 YGL055W OLE1
SGTC_1256 0570-0116 285 µM 1.50319266308457 0.0817903130221318 no 400 0.066394684482756 392 410638
SGTC_1671 st016596 74.5 µM 1.49613780425082 0.0827817275310066 no 401 0.0673088740967775 445 2829167
SGTC_2225 6654152 15.4 µM 1.49513707180687 0.0829230889935855 no 402 0.0674393362668482 333 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_925 2064-1272 59.6 µM 1.49260435221237 0.0832816671751005 no 403 0.0677703917177773 404 6815817
SGTC_2735 sertaconazole 140 nM 1.49115546553744 0.0834873216168967 no 404 0.0679603414505617 319 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_322 k048-0136 19.3 µM 1.4903401409799 0.0836032161710889 no 405 0.0680674114968261 397 6823282
SGTC_2855 9016525 58.44 µM 1.48950697886637 0.0837217710855683 no 406 0.0681769584914888 411 43811474
SGTC_1321 1326-2144 215 µM 1.48778774275884 0.0839668091375013 no 407 0.0684034395878718 382 3513030
SGTC_539 4859-0462 2.54 µM 1.48485036626878 0.0843867108901893 no 408 0.0687917332238726 402 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1495 4469-0029 237 µM 1.48259881970777 0.0847096376455376 no 409 0.0690905154616122 571 793680
SGTC_1484 3473-2379 286 µM 1.4823780827789 0.0847413465245801 no 410 0.0691198611927973 510 671917
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.4759131031974 0.0856739938014248 no 411 0.0699836107182902 456 5393153
SGTC_1898 st060199 18.6 µM 1.4749981880125 0.0858065991281574 no 412 0.0701065152874377 410 688866
SGTC_1281 0884-0031 11.8 µM 1.47408198621311 0.0859395448247986 no 413 0.0702297590149256 471 1548255
SGTC_3194 9111903 49.47 µM 1.47180919272574 0.0862700044860453 no 414 0.070536205251405 445 17087251
SGTC_3259 9138485 49.47 µM 1.47151594755858 0.0863127108778559 no 415 0.0705758189553622 473 17646153
SGTC_2443 5493264 126.67 µM 1.4674081240143 0.0869126115744383 no 416 0.0711325329094232 423 5340055
SGTC_1838 st055369 84.5 µM 1.46611609201664 0.0871019405499818 no 417 0.0713083312342168 388 676036
SGTC_1188 1403-0014 4.57 µM 1.46032460846143 0.0879543862500847 no 418 0.0721004409637752 507 9614867
SGTC_2756 carbadox 75.1 µM 1.45775972558033 0.0883338917183787 no 419 0.0724533914741307 481 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3285 9112818 20.8695 µM 1.45749764361301 0.088372738528796 no 420 0.0724895306718666 474 17017947 YPR165W RHO1
SGTC_2196 6573537 42.6665 µM 1.44424016035013 0.0903544626099877 no 421 0.0743357158446769 400 2903087
SGTC_125 0133-0007 11.75 µM 1.44152440178303 0.0907644547006237 no 422 0.0747182943032443 457 26541
SGTC_3159 9100096 49.47 µM 1.44045044255826 0.0909269683249377 no 423 0.0748700006088362 448 25236875
SGTC_2308 7584454 197.62 µM 1.4383092035117 0.0912516289212488 no 424 0.0751731708404511 511 893577
SGTC_493 zm226600 134 µM 1.43710853652483 0.0914340530706729 no 425 0.0753435780012836 467 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2264 7948757 110.76 µM 1.4368068218833 0.0914799367581695 no 426 0.0753864457369234 424 2971411
SGTC_3272 9137413 49.47 µM 1.43662630454911 0.0915073973495306 no 427 0.0754121025982566 440 17614870
SGTC_1647 st011722 22.4 µM 1.43429496834463 0.0918625931160796 no 428 0.0757440527950738 426 2854783
SGTC_2055 5235184 200 µM 1.43394498306394 0.0919160039185224 no 429 0.0757939818211353 469 2836034
SGTC_2379 9035213 200 µM 1.43316257370993 0.092035489572629 no 430 0.0759056912762763 499 646551
SGTC_1618 st003135 44.5 µM 1.42934492745814 0.0926201514594239 no 431 0.0764525594646385 436 1270615
SGTC_2068 5226020 147 µM 1.42686625430644 0.0930012215012212 no 432 0.0768092246979584 513 1810509
SGTC_1702 st027038 51 µM 1.42648331326346 0.0930601978857849 no 433 0.0768644401060441 485 5521182
SGTC_1019 4262-0212 3.4 µM 1.42146249037062 0.0938360088689214 no 434 0.0775911753650748 563 4677213
SGTC_3330 9141424 71.43 µM 1.4185232904247 0.0942923799465714 no 435 0.0780190219240841 508 27261020
SGTC_1905 st060207 84.5 µM 1.41761015870665 0.0944344951261221 no 436 0.0781523063018075 456 1948547
SGTC_2242 6630449 61.2675 µM 1.41384429033538 0.0950222646961229 no 437 0.0787038130252698 412 691249 YDR170C SEC7
SGTC_2903 5923464 63.88 µM 1.41085661503523 0.0954904889949571 no 438 0.0791434484523133 436 2876576
SGTC_2515 chrysin 20.77 µM 1.407995311356 0.0959404982927621 no 439 0.0795662291765843 470 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_364 0083-0097 67.7 µM 1.40513461983148 0.096391968510983 no 440 0.0799906255941698 475 5207356
SGTC_2617 dihydrotanshinone i 20.83 µM 1.40116388532023 0.0970212087758151 no 441 0.0805825355743159 514 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2749 bexarotene 57.39 µM 1.40010216375977 0.0971899690183842 no 442 0.0807413636068552 490 82146 An retinoic acid receptor inhibitor.
SGTC_2476 5806916 10.51 µM 1.39897796453163 0.0973688947545869 no 443 0.0809097955189635 443 2870194
SGTC_170 4197-0004 226 µM 1.39652844261577 0.0977595933721979 no 444 0.0812777108541584 422 218692
SGTC_1183 1254-0324 198 µM 1.39558373818532 0.0979105803702316 no 445 0.0814199411157599 485 5799357
SGTC_518 1021-0119 62.6 µM 1.39426299359401 0.098121954228398 no 446 0.0816191007883983 493 1097762
SGTC_2462 5162487 171.77 µM 1.39387872715585 0.0981835155191289 no 447 0.081677114584847 477 2259986
SGTC_3112 9123419 49.47 µM 1.38916123931001 0.0989415862888208 no 448 0.0823918626355842 521 17015854
SGTC_997 3996-0078 137 µM 1.38885409864605 0.0989910899307684 no 449 0.0824385603933377 504 735687
SGTC_1880 MG-132 525 µM 1.38517104822189 0.0995861203905981 no 450 0.083000085595555 445 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2252 omeprazole 400 µM 1.38488663970728 0.0996321776626453 no 451 0.083043566447539 363 4594 A proton pump inhibitor.
SGTC_636 0kpi-0074 126 µM 1.3848151553632 0.0996437563241304 no 452 0.0830544977878836 454 616434
SGTC_3193 9111931 49.47 µM 1.38104904043122 0.10025516318548 no 453 0.0836319413094379 493 17087244
SGTC_2150 5556613 200 µM 1.38005792402738 0.100416519360821 no 454 0.0837844054666348 530 743190
SGTC_3135 9127742 49.47 µM 1.37453631240911 0.101318920786017 no 455 0.0846376225309667 456 3643468
SGTC_1513 0337-0559 19 µM 1.37403764584024 0.101400708221513 no 456 0.084714997768373 432 775073
SGTC_2142 5622915 118.518 µM 1.37203072650873 0.101730353880506 no 457 0.085026936355273 443 5322196
SGTC_1902 st060212 70.5 µM 1.36983637264909 0.102091678645875 no 458 0.0853689925917036 505 688944
SGTC_89 0302-0250 142.109 µM 1.36666293467546 0.102615870725469 no 459 0.0858654904097607 538 4203518 YLR208W SEC13
SGTC_2189 6047310 154.431 µM 1.36207926548417 0.103376456001275 no 460 0.0865864355611693 475 711535
SGTC_43 0570-0105 72.5 µM 1.35783475756772 0.104084404786324 no 461 0.0872580616291221 611 1114046 YDL195W SEC31
SGTC_3223 9129970 49.47 µM 1.34933386483805 0.105512839761632 no 462 0.0886148764559396 545 17248386
SGTC_1505 k297-0037 20.6 µM 1.34393146989445 0.106427960167355 no 463 0.089485274237964 530 4089396
SGTC_1759 st043059 70 µM 1.34316603201864 0.106558081027322 no 464 0.0896091089761469 538 669426
SGTC_1309 pyrazolanthrone 13.4 µM 1.34216600869507 0.106728253294152 no 465 0.0897710875524451 548 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3127 9126946 49.47 µM 1.34034196141819 0.107039153260707 no 466 0.0900670976422676 453 27243249
SGTC_1992 st073643 23.3 µM 1.33748853264624 0.107526815603841 no 467 0.0905316114781256 504 3161292
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.33738542150155 0.107544467634271 no 468 0.0905484303253202 435 4620898
SGTC_1272 0839-0021 27 µM 1.33022505942325 0.108775392354684 no 469 0.091722064973707 547 5027250
SGTC_2202 7226349 200 µM 1.31273644026214 0.111824337904817 no 470 0.0946358869898103 469 844334
SGTC_10 0279-0212 42.575 µM 1.31260177030357 0.111848050883117 no 471 0.0946585863879662 659 39851 YBR002C RER2
SGTC_2185 6113692 200 µM 1.31174075505526 0.111999745314937 no 472 0.0948038103319195 483 874150
SGTC_956 1185-0240 191 µM 1.30993764344237 0.112317895565003 no 473 0.0951084656357812 519 1416193
SGTC_2783 7738165 71.43 µM 1.30403782115032 0.113363402511595 no 474 0.0961103436552757 439 17201110
SGTC_308 4092-1169 104 µM 1.30372625156773 0.113418808054832 no 475 0.0961634677177548 573 2268590 YDL196W YDL196W
SGTC_3298 9116858 71.43 µM 1.30280444252129 0.113582843850678 no 476 0.0963207668515342 563 2506942
SGTC_4 0960-0234 25.671 µM 1.30250972833969 0.1136353238663 no 477 0.0963710972752225 501 6821112
SGTC_1424 4048-1941 275 µM 1.29478851680748 0.115016410402341 no 478 0.0976965971950005 596 X1424
SGTC_1812 st052057 4.327 µM 1.29252824229135 0.115422953152398 no 479 0.0980871359312446 575 3645418
SGTC_1558 st069300 45.6 µM 1.29206286211181 0.11550678506315 no 480 0.0981676878747818 453 24208000
SGTC_2931 9014674 55.67 µM 1.28909557813922 0.116042318308562 no 481 0.0986824303231547 534 2996810
SGTC_3007 9078383 71.4286 µM 1.28778351906608 0.116279678892807 no 482 0.0989106654310613 550 6496995
SGTC_2448 5185112 27.17 µM 1.2851595117317 0.116755412974637 no 483 0.0993682744366523 504 5718189
SGTC_3093 9117344 49.47 µM 1.28508197520983 0.116769491350647 no 484 0.0993818197807548 522 24824913
SGTC_1711 st032263 62.8 µM 1.28197923307783 0.117333846971075 no 485 0.0999249656278069 528 3958979
SGTC_1093 fluphenazine 7.97 µM 1.28163777695381 0.117396071979199 no 486 0.09998487087729 598 6602611 An atypical antipsychotic.
SGTC_1311 1190-0148 100 µM 1.2778597839279 0.118086111772353 no 487 0.100649435137211 671 1961333
SGTC_1047 2043-3044 82 µM 1.277022688796 0.118239392280812 no 488 0.100797118590086 570 669592
SGTC_3239 9133757 49.47 µM 1.27645134992394 0.118344090899479 no 489 0.100898007022013 542 17036923
SGTC_2213 7173844 200 µM 1.27556632560172 0.118506402163998 no 490 0.101054432127718 584 892728
SGTC_2731 amoxapine 43.43 µM 1.27464226369227 0.118676040650266 no 491 0.101217945549751 427 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2729 fluphenazine 10.66 µM 1.27313494540705 0.118953120884978 no 492 0.101485080194358 565 3372 An atypical antipsychotic.
SGTC_853 0419-0306 21 µM 1.27058649590805 0.119422623830552 no 493 0.101937896800776 536 762713
SGTC_3312 9133330 71.43 µM 1.26675614495339 0.120130749474884 no 494 0.102621248794386 600 17617324
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.26606477206885 0.120258879732142 no 495 0.102744946788388 547 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2864 9034755 47.6 µM 1.26421356834753 0.120602432233072 no 496 0.103076691044519 565 4930451
SGTC_1724 st037281 8.293 µM 1.26374252727295 0.120689959770314 no 497 0.103161227808549 591 574124 YDL195W SEC31
SGTC_830 4076-0286 57.8 µM 1.26185902875982 0.121040393075761 no 498 0.103499758544924 726 6866659
SGTC_3308 9128332 17.569 µM 1.2614416440508 0.121118146160323 no 499 0.103574886223379 664 17332805 YDL196W YDL196W
SGTC_2692 st077426 47.7 µM 1.25959381260111 0.121462794044191 no 500 0.103907964364352 593 25238571
SGTC_2566 crystal violet carbinol 226 nM 1.25837706574426 0.121690111435767 no 501 0.10412771103819 512 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3238 9133470 49.47 µM 1.2582142015574 0.121720561028856 no 502 0.104157150151081 552 3534688
SGTC_108 0509-0257 621.132 µM 1.25619086222594 0.12209929728152 no 503 0.10452338947954 626 536624
SGTC_1878 temozolomide 1 mM 1.2508493802498 0.123103109276357 no 504 0.105494717487832 547 5394 DNA alkylating agent.
SGTC_370 0180-0345 38.7 µM 1.24878259649679 0.123493062863439 no 505 0.105872300520986 513 3989527
SGTC_2937 9044753 11.33 µM 1.24831777087972 0.123580883593696 no 506 0.105957354407058 611 6465530 YGL099W LSG1
SGTC_1032 k061-1018 98.7 µM 1.24389398734689 0.124418869855131 no 507 0.106769291283177 671 4005393
SGTC_800 3448-7362 155 µM 1.2425378368463 0.124676555967999 no 508 0.107019094645468 847 15991913
SGTC_126 0417-1624 672.48 µM 1.2412999674276 0.124912092578335 no 509 0.107247478364317 727 41912 YDL195W SEC31
SGTC_3279 9140807 49.47 µM 1.23984971001597 0.125188436724742 no 510 0.107515493885505 578 45595718
SGTC_1052 3253-3998 198 µM 1.23946752077571 0.125261333272503 no 511 0.107586204847336 637 5450317
SGTC_692 k241-0027 77.8 µM 1.23787416521343 0.125565559930157 no 512 0.107881361512173 576 3600480
SGTC_2047 4141938 200 µM 1.23762972617219 0.1256122773714 no 513 0.107926693480505 532 3807862
SGTC_1846 st056244 14.8 µM 1.23703721304388 0.12572556941496 no 514 0.108036633775682 618 5393182
SGTC_1319 1306-0155 43.7 µM 1.22982089116112 0.127111095566704 no 515 0.109382091638131 650 3122360
SGTC_2302 7771753 200 µM 1.22718811160359 0.127619221934107 no 516 0.109875948337064 624 2203047
SGTC_2773 thioridazine 9.09 µM 1.22466791310303 0.128106941389021 no 517 0.110350184201209 612 5452 An antipsychotic.
SGTC_818 4072-2707 53.5 µM 1.22261788181883 0.128504625841457 no 518 0.110737027971128 572 882871
SGTC_268 camptothecin 39.6153 µM 1.22078809937834 0.128860307376802 no 519 0.111083130407696 701 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1979 st071809 45.3 µM 1.21871748119963 0.129263626592509 no 520 0.111475720324334 616 4976333
SGTC_1378 2093-0007 380 nM 1.2183203136305 0.129341087600105 no 521 0.111551136787716 611 3618014
SGTC_2790 5423970 71.43 µM 1.2153541184159 0.129920612516386 no 522 0.112115529651422 646 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1821 st053465 65.6 µM 1.21344159946395 0.13029522563505 no 523 0.112480514898726 574 675086
SGTC_1384 3089-0840 101 µM 1.21248340532478 0.130483191862146 no 524 0.112663695558298 569 1069836
SGTC_2721 ifenprodil 61.44 µM 1.21096507045989 0.130781423168971 no 525 0.112954395970975 604 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_849 0386-0493 241 µM 1.20944885848546 0.131079707329614 no 526 0.113245223801419 578 726119
SGTC_500 h-89 112 µM 1.20729836911017 0.131503578283692 no 527 0.113658629268502 657 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_710 3448-4187 58 µM 1.20672029554963 0.131617680309926 no 528 0.113769940129534 714 3946412
SGTC_1555 citronellol 128 µM 1.20087033980283 0.132776208201181 no 529 0.114900750616061 583 8842 A terpine precursor.
SGTC_2742 clothiapine 36.27 µM 1.19458598630454 0.134028567791514 no 530 0.116124413565545 561 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1530 rhein 70.4 µM 1.19128146473213 0.134690345795967 no 531 0.116771553922274 670 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2109 5483026 200 µM 1.19083734206787 0.134779458396871 no 532 0.116858723118494 636 759335
SGTC_2706 st078239 82.5 µM 1.18786906874237 0.135376076978975 no 533 0.117442498790777 634 15434492
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.18775555134515 0.135398929689396 no 534 0.117464865385298 661 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2289 7946404 165.07 µM 1.18764039400828 0.135422115244986 no 535 0.117487558182492 700 1246120 YPR165W RHO1
SGTC_1091 telmisartan 47.6 µM 1.18668719509906 0.135614134943307 no 536 0.117675513854085 630 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1370 2001-0092 44.6 µM 1.18575230310041 0.135802647865599 no 537 0.117860066330526 739 790957
SGTC_1802 st050112 57.9 µM 1.18379107448499 0.136198695634372 no 538 0.118247888130091 640 4662563
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.1837122603615 0.136214627751747 no 539 0.118263492011237 670 5106787 A p450 inhibitor.
SGTC_3241 9133421 49.47 µM 1.18365556747134 0.136226088894688 no 540 0.118274717157591 597 17018221
SGTC_1700 st030840 7.9285 µM 1.18283519180093 0.136392011473848 no 541 0.118437235201296 686 5499307
SGTC_1342 1486-1464 234 µM 1.18042095615021 0.136881097180872 no 542 0.118916415592294 658 3253938
SGTC_2847 9005661 71.43 µM 1.17989416047307 0.136987976716191 no 543 0.119021156348018 505 2991449
SGTC_3043 9092303 49.47 µM 1.17890239552617 0.137189346774698 no 544 0.119218521872605 588 25236084
SGTC_2283 7944793 200 µM 1.17284326426195 0.138423996065323 no 545 0.120429332445402 623 2970533
SGTC_1887 st057648 70.8 µM 1.17256411834951 0.13848105860834 no 546 0.120485322782441 638 688672
SGTC_951 1171-0579 82.7 µM 1.17230358868272 0.138534330109197 no 547 0.12053759565964 720 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_724 3910-0327 137 µM 1.17226119879591 0.138542999052654 no 548 0.120546102310202 658 2885483
SGTC_1608 st001473 40.5 µM 1.17131088070822 0.138737440874975 no 549 0.120736919715399 605 7292267
SGTC_1387 3342-1166 1.8 µM 1.16885007848616 0.139241801969081 no 550 0.121232019871594 572 3418228
SGTC_1954 st077032 68.9 µM 1.16728589648884 0.139563041391253 no 551 0.121547466143733 568 698907
SGTC_1694 st024011 44.9 µM 1.16242689990788 0.140564156773856 no 552 0.12253105092174 697 2787533
SGTC_722 3534-0461 190 µM 1.15904119274863 0.141264600225842 no 553 0.123219697329313 648 658262
SGTC_1284 0929-0043 16 µM 1.15764274818272 0.141554603224252 no 554 0.123504928309259 667 1239883
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.15554181323457 0.141991043178853 no 555 0.123934310072858 638 5355888
SGTC_1631 benzylvanillin 81.9 µM 1.15499388846027 0.142105016527076 no 556 0.1240464645938 672 75506
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.15227376846521 0.142671742850146 no 557 0.124604296312698 642 6710655
SGTC_1318 1280-3875 124 µM 1.15019036137303 0.14310684463091 no 558 0.125032737617202 687 373245
SGTC_1388 3346-4487 254 µM 1.1483550343138 0.143490878939498 no 559 0.125411014198018 702 3345614
SGTC_1327 1436-0082 2.18 µM 1.14734510583976 0.143702498618107 no 560 0.125619509472817 656 15992205
SGTC_1928 4'-methoxychalcone 40.3 µM 1.14689406121083 0.143797078180781 no 561 0.125712703728931 672 641818
SGTC_144 4161-2749 112.381 µM 1.14668222628746 0.143841512343693 no 562 0.125756489427705 585 797501 YMR168C CEP3
SGTC_3025 9087895 49.47 µM 1.13825972334846 0.145615710705594 no 563 0.127506023398559 725 17173641
SGTC_1596 piperlongumine 63 µM 1.13747896167531 0.145780920002575 no 564 0.127669057289849 739 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_87 0100-0052 35.5 µM 1.13542664067306 0.146215792120192 no 565 0.128098301349686 882 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2041 5107442 45.335 µM 1.13471682844602 0.146366398809862 no 566 0.128246992006294 690 793005
SGTC_907 3448-6986 75.5 µM 1.13455651298567 0.146400428671306 no 567 0.128280591291097 730 590582
SGTC_1911 st060208 74.3 µM 1.13384535599115 0.146551448670392 no 568 0.128429710911657 705 688783
SGTC_2394 5221648 200 µM 1.13379062555833 0.146563075456574 no 569 0.12844119209842 759 788586
SGTC_2365 9042475 200 µM 1.13323656183875 0.146680814122843 no 570 0.128557462047451 660 6464479
SGTC_174 3553-0389 74.3 µM 1.13279313475727 0.146775088188368 no 571 0.128650567571591 608 738071
SGTC_3237 9133362 49.47 µM 1.13196922121693 0.146950362848981 no 572 0.128823687313751 669 43845137
SGTC_1015 4130-4525 82 µM 1.13177067855944 0.146992620660701 no 573 0.128865429014696 681 1363237
SGTC_2967 9089538 49.85 µM 1.13014921962199 0.147338036944417 no 574 0.129206676472142 702 728216
SGTC_1207 2099-0101 141 µM 1.12569419187935 0.148289881535116 no 575 0.130147491520166 729 5837381
SGTC_464 bw-b 70c 158 µM 1.12544002068172 0.148344310565543 no 576 0.13020131010543 732 5353454
SGTC_281 1672-3440 14.9 µM 1.12509295769486 0.148418653318415 no 577 0.130274822602072 736 6833000
SGTC_2062 5245942 200 µM 1.12349359109294 0.148761568166955 no 578 0.130613960487906 714 1376160
SGTC_652 0437-0092 114 µM 1.12322360978694 0.1488195061535 no 579 0.130671268870985 652 3091274
SGTC_19 0279-0214 38.434 µM 1.12294330151889 0.148879676260121 no 580 0.130730787728679 777 3566274 YBR002C RER2
SGTC_2377 9073351 62.6 µM 1.12287328180966 0.148894709011684 no 581 0.130745658188964 670 7337946 YHR072W ERG7
SGTC_1719 st032227 49.2 µM 1.12233052579745 0.149011269407432 no 582 0.130860965846465 662 3125804
SGTC_2368 9071271 200 µM 1.11344200771188 0.150928809447564 no 583 0.132759320951602 666 27209959
SGTC_3027 9089541 49.47 µM 1.11109765218339 0.151437287663598 no 584 0.133263159183941 699 9943819
SGTC_1304 1165-0502 251 µM 1.10968686193198 0.151743828913236 no 585 0.133566993120918 734 767425
SGTC_991 3996-0057 64.7 µM 1.10926922033155 0.151834654533499 no 586 0.133657029550008 700 715343
SGTC_1066 ketoconazole 628 nM 1.1063728206329 0.152465535938303 no 587 0.134282592272718 746 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_894 0960-0238 55.9 µM 1.10604554721273 0.152536930464941 no 588 0.134353402826715 707 6741907 YDL195W SEC31
SGTC_1529 apigenin 74 µM 1.10466553676535 0.152838222974321 no 589 0.134652270943765 720 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2777 climbazole 1.536 µM 1.10435886393338 0.152905231263105 no 590 0.134718748829878 721 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_582 0987-0078 156 µM 1.10132412060656 0.153569375434434 no 591 0.135377808449403 834 1625765
SGTC_1074 carmofur 3.8 µM 1.10105385415885 0.15362861490786 no 592 0.13543660958633 768 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1921 5740136 50 µM 1.09827179138863 0.154239292323418 no 593 0.136042912857037 765 1774243
SGTC_1280 0880-0253 10.1 µM 1.09731632995719 0.154449390983527 no 594 0.136251567398522 721 6836607
SGTC_361 000s-0510 1.45 µM 1.09223402249954 0.155570129894014 no 595 0.137365125872073 706 660
SGTC_2161 5662504 8.5105 µM 1.09176600865668 0.155673604318583 no 596 0.137467981601975 677 2859334
SGTC_1783 st039459 87.517 µM 1.08974481979864 0.156120995516674 no 597 0.137912783483561 774 729761
SGTC_307 1501-1223 22.3 µM 1.08763821100774 0.156588195279255 no 598 0.138377427528931 704 2830329
SGTC_1462 k081-0014 26.5 µM 1.08628726471785 0.156888289524597 no 599 0.138675959808187 555 3270634
SGTC_1915 st067105 30.6 µM 1.08453991761078 0.157276999660703 no 600 0.139062739065369 709 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.08334806264681 0.157542499437325 no 601 0.13932697974576 580 88881 An O-methylated flavonoid and antioxidant.
SGTC_3138 9097216 49.47 µM 1.08179869695234 0.157888078973123 no 602 0.139670992873767 716 25237486
SGTC_3022 9087993 49.47 µM 1.0814994876478 0.157954873661244 no 603 0.139737494235967 704 17173644
SGTC_1108 betulinic acid 729.144 nM 1.07313887849227 0.159828774931022 no 604 0.141604404713325 733 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1030 k029-0042 36.7 µM 1.06632279902464 0.161367210985641 no 605 0.143138873357431 769 6080581
SGTC_1607 st000305 50.6 µM 1.06501117469161 0.161664358010258 no 606 0.143435436456856 747 5457690
SGTC_1623 st003709 20.3 µM 1.06144593787738 0.162473859516298 no 607 0.144243644749022 795 16192618
SGTC_2508 celastrol 40.54 µM 1.06095345832813 0.162585885993262 no 608 0.144355526442394 687 122724 Celastrol is a natural product and antioxidant.
SGTC_2130 NSC 7 2.4545 µM 1.06018093315769 0.162761716894034 no 609 0.144531146811716 788 21448
SGTC_2872 9044037 25.97 µM 1.05893549350054 0.163045445997351 no 610 0.144814579185946 709 6465195
SGTC_1471 k673-0312 37 µM 1.05795429394207 0.163269203679918 no 611 0.145038140237372 737 24099884
SGTC_50 0929-0078 56.389 µM 1.05343977695524 0.164301286309883 no 612 0.146069740913233 709 1377751
SGTC_1826 st055655 41.6 µM 1.05271933889994 0.164466379225045 no 613 0.146234821313346 760 676168
SGTC_923 1900-2434 73.3 µM 1.04879717790078 0.165367052496907 no 614 0.147135738311005 723 5910570
SGTC_487 nimodipine 119 µM 1.03925374126436 0.16757188129485 no 615 0.149343371272019 655 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1481 3346-2004 36 µM 1.03735222173908 0.168013443194953 no 616 0.1497858682051 782 2770522
SGTC_639 0833-0042 114 µM 1.03609031677628 0.168306889806717 no 617 0.15008000463593 794 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1180 1193-0155 285 µM 1.03579687940962 0.168375173696373 no 618 0.150148456864775 720 2921347
SGTC_1156 4092-0367 4.88 µM 1.0344184190031 0.168696184590572 no 619 0.150470298644551 762 1357585
SGTC_2204 7233102 200 µM 1.03203070317235 0.169253157345328 no 620 0.151028867252725 723 2172480
SGTC_382 3229-0966 23.2 µM 1.029647493986 0.169810254663094 no 621 0.151587755822098 809 5722370
SGTC_2591 skatole 100 µM 1.02779335039552 0.170244490302505 no 622 0.152023522437289 756 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3227 9130768 49.47 µM 1.02631036071083 0.170592314258249 no 623 0.152372657588931 807 17720899
SGTC_1605 st000082 49.1 µM 1.02537854522374 0.170811097079107 no 624 0.152592303744494 787 1114022
SGTC_2778 tioconazole 65.09 nM 1.02478459667993 0.170950645106586 no 625 0.152732417977931 760 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1562 morin hydrate 59.1 µM 1.02469594095075 0.170971480997169 no 626 0.15275333944606 760 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_994 3910-0338 138 µM 1.02460730534541 0.170992313782252 no 627 0.152774258065306 804 3479481
SGTC_3044 9093193 49.47 µM 1.01873583936559 0.172375950527047 no 628 0.154164196524961 786 25236277
SGTC_2070 5230947 200 µM 1.01678498810482 0.172837253544015 no 629 0.154627862514502 831 2835538
SGTC_1413 3910-0535 34.4 µM 1.01343981417118 0.173630090803721 no 630 0.155425065120147 827 2876951
SGTC_315 k915-0449 187 µM 1.01288946246245 0.173760750591987 no 631 0.155556481101092 879 20970215 YNL149C PGA2
SGTC_3351 9150312 21.596 µM 1.0114457586462 0.174103799520744 no 632 0.155901564808582 776 4904905
SGTC_1094 duloxetine 25.4 µM 1.00966194770484 0.17452825791361 no 633 0.156328639644433 769 60834 A selective serotonin reuptake inhibitor.
SGTC_1780 st038448 24.544 µM 1.00827391512995 0.174858994977669 no 634 0.156661490974706 795 728868 YDL195W SEC31
SGTC_1474 0330-0125 5.35 µM 1.00448607384507 0.17576357499077 no 635 0.15757219019806 806 X1474
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.00418144835625 0.175836451621405 no 636 0.157645581206816 790 2724278 An inhibitor of dopamine biosynthesis.
SGTC_584 0986-0246 15.4 µM 1.00364952948005 0.175963750330455 no 637 0.157773786047396 873 53315 YDR232W HEM1
SGTC_905 2-aminofluorene 215 µM 0.998485435428362 0.17720265219884 no 638 0.15902201174711 862 1539 An established DNA mutagen. YPR165W RHO1
SGTC_208 k072-0098 12.366 µM 0.99693149401926 0.177576529203159 no 639 0.159398881710398 899 5948901
SGTC_2002 4023503 131 µM 0.996742115440267 0.177622127539475 no 640 0.159444850732368 916 4736863 YCR052W RSC6
SGTC_1173 0443-0020 122 µM 0.994952794867858 0.178053322545991 no 641 0.159879611815931 789 5331295
SGTC_400 oxethazaine 37.5 µM 0.994747825666414 0.178102758639106 no 642 0.159929463766672 776 4621 A local anesthetic.
SGTC_1801 st050089 28.441 µM 0.994660963592811 0.178123711331225 no 643 0.159950593147964 888 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2205 7238770 200 µM 0.993830640704127 0.1783240785378 no 644 0.160152663064014 803 279867
SGTC_1824 st053723 68.6 µM 0.993099607778171 0.178500603360216 no 645 0.160330707559028 813 675225
SGTC_828 2074-0507 139 µM 0.992505740278804 0.178644087414076 no 646 0.160475440335497 835 X828
SGTC_1338 1486-1223 76 µM 0.99141357953001 0.178908153412577 no 647 0.160741836045218 849 3444526
SGTC_2728 chlorpromazine 9.18 µM 0.991280208165078 0.178940417175893 no 648 0.160774387256781 708 2726 A thorazine and dopamine antagonist.
SGTC_838 0109-0203 71.4 µM 0.989457224445435 0.179381780758332 no 649 0.161219744258297 822 759422
SGTC_1840 st055363 71 µM 0.987797407306182 0.179784234761543 no 650 0.161625938794298 755 676033
SGTC_2310 7668677 200 µM 0.982275133171993 0.181127293049676 no 651 0.162982160883206 793 2197143
SGTC_596 1155-0152 116 µM 0.977645765358447 0.182258019534369 no 652 0.164124777040163 855 280313
SGTC_202 3594-0513 34.79 µM 0.977505251969391 0.182292408870309 no 653 0.164159539473754 790 708429
SGTC_1168 k815-0004 80.5 µM 0.977072464862276 0.182398354936784 no 654 0.164266639224234 821 642433
SGTC_1936 st074407 74.3 µM 0.976965251672168 0.182424606616025 no 655 0.164293177759168 853 809813
SGTC_1360 1598-0022 39.8 µM 0.976437087047485 0.182553964786023 no 656 0.164423955193459 894 761525
SGTC_1391 3442-0225 151 µM 0.972175866742738 0.183599718191757 no 657 0.16548153220002 798 5227075
SGTC_581 0958-0271 211 µM 0.971763458872573 0.18370112567166 no 658 0.165584119258537 870 4591145
SGTC_1527 coumarin 137 µM 0.970196276551666 0.184086800242643 no 659 0.165974333176002 774 323 A hepatotoxic, DNA x-linker.
SGTC_1957 st077035 62.4 µM 0.968185237828303 0.184582443143319 no 660 0.166475933050955 855 705593
SGTC_1899 st063254 59.6 µM 0.966878242612346 0.184905011181983 no 661 0.166802452227731 739 3093813
SGTC_1760 st045453 10.4495 µM 0.966065548881302 0.185105761524676 no 662 0.167005691065123 881 3323419 YIL048W NEO1
SGTC_850 0388-0143 75.9 µM 0.959541282148325 0.186722277980623 no 663 0.168643066634785 788 67273
SGTC_2418 pentamidine 31.67 µM 0.957444473007516 0.187243654052238 no 664 0.169171480158024 781 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_819 1013-0258 27.7 µM 0.957175554280151 0.187310586336136 no 665 0.169239326769297 833 5753198
SGTC_1893 st059353 36.1 µM 0.95593386366064 0.18761982759462 no 666 0.169552824505357 832 3112488
SGTC_3067 9117431 49.47 µM 0.95297245329821 0.188358634877545 no 667 0.170302013983265 806 17150885
SGTC_812 4251-0442 148 µM 0.946353467382887 0.190016403945822 no 668 0.17198416542086 853 5723007
SGTC_1152 3909-8331 15.9 µM 0.945409150867586 0.190253643146848 no 669 0.172225016096665 822 16001939
SGTC_1106 tegaserod maleate 11.7 µM 0.945401245632284 0.190255629934792 no 670 0.17222703325793 882 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_147 4466-0538 29.23 µM 0.941100271298113 0.191338464103347 no 671 0.173326738268354 883 6742687 YHR072W ERG7
SGTC_619 1652-1634 108 µM 0.940202094595598 0.191565069272206 no 672 0.17355695379932 812 5400454
SGTC_2923 7992654 58.14 µM 0.939277553241458 0.191798497731391 no 673 0.173794130106207 838 2985126
SGTC_2817 7995342 71.43 µM 0.935199165517399 0.192830287224748 no 674 0.174842834252956 777 18879975
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.934319751146937 0.19305321347274 no 675 0.175069489479723 698 4000243
SGTC_841 0251-0215 91.2 µM 0.932614670438656 0.193485889264455 no 676 0.175509478010093 916 3888614
SGTC_512 prima-1 270 µM 0.931996832549168 0.193642815712392 no 677 0.175669081183111 915 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3072 9116419 49.47 µM 0.930796491545988 0.193947915610728 no 678 0.175979422449882 801 17170162
SGTC_3180 9109287 49.47 µM 0.930771515917632 0.193954266967596 no 679 0.175985883439641 822 18891271
SGTC_195 4234-0266 16.654 µM 0.93047995650956 0.194028420537982 no 680 0.1760613185727 910 2303354
SGTC_872 0588-0139 234 µM 0.930255922299488 0.194085411865894 no 681 0.176119296824943 900 2047100
SGTC_1591 genipin 88.4 µM 0.929784950771874 0.194205254017355 no 682 0.17624121987404 851 442424 A DNA cross-linking agent.
SGTC_1363 1636-0063 10.4 µM 0.929114732885048 0.194375873544491 no 683 0.176414815017044 907 6072185
SGTC_1732 st034308 51.822 µM 0.927332373532046 0.194830058368018 no 684 0.176876995380015 824 830119
SGTC_1942 st076330 65.2 µM 0.926518554851645 0.195037651942522 no 685 0.177088279473959 892 24208414
SGTC_219 mitoxanthrone 164.414 µM 0.924817905928233 0.195471897195918 no 686 0.177530317446905 829 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2658 polymyxin b sulfate 77.05 µM 0.923748653526769 0.195745221496695 no 687 0.177808597130013 894 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_750 4073-0104 132 µM 0.922080495340583 0.196172102202046 no 688 0.178243294986959 750 22330957
SGTC_1731 st035964 63 µM 0.920089652194222 0.196682296032389 no 689 0.178762955690192 844 6739575
SGTC_2495 cafestol 54.53 µM 0.920054242310753 0.19669137780004 no 690 0.178772207195256 827 16667697 An anti-infammatory.
SGTC_2193 5925765 200 µM 0.919269936999021 0.196892598011609 no 691 0.17897719913418 868 877370
SGTC_957 1187-1561 14.1 µM 0.918350421048357 0.197128666310009 no 692 0.179217719022 875 1538454
SGTC_1279 0874-0590 65.2 µM 0.916878081172328 0.197507018169046 no 693 0.179603265465706 892 3523074
SGTC_3191 9110352 49.47 µM 0.915713101591676 0.197806697585021 no 694 0.179908695731751 868 17122424
SGTC_704 1310-0270 142 µM 0.915614803928667 0.197831996244118 no 695 0.179934481983768 915 5718033
SGTC_2666 tannic acid 100 µM 0.913471043168743 0.198384217440347 no 696 0.180497428139856 928 16134267 A thiamine antagonist.
SGTC_709 3807-1509 243 µM 0.913097637941372 0.198480499640471 no 697 0.180595596263175 897 1886677 YPL242C IQG1
SGTC_3196 9111891 49.47 µM 0.912608372792074 0.198606698876875 no 698 0.180724274593973 895 18891510
SGTC_2918 7977171 22.06 µM 0.909432786292753 0.199426973668129 no 699 0.181560860963048 899 2236483
SGTC_540 1187-0821 17.3 µM 0.908573941447341 0.199649168816989 no 700 0.181787533450028 884 847520
SGTC_1456 k015-0012 13 µM 0.907935111565466 0.199814539592615 no 701 0.181956252771534 976 2989616
SGTC_679 0422-0091 41.4 µM 0.907746360727929 0.199863416364889 no 702 0.182006121887411 931 627384 YHR062C RPP1
SGTC_1138 3761-0006 1.03 µM 0.907489094120206 0.199930046780724 no 703 0.182074107046187 908 12061087
SGTC_1540 guanosine 70.6 µM 0.905496176259301 0.200446652213342 no 704 0.18260129234323 849 6802 Guanosine is a purine nucleoside
SGTC_1389 3405-0187 19 µM 0.904169954879593 0.200790880042433 no 705 0.182952644538272 831 799890
SGTC_527 4476-4215 268 µM 0.903547465952439 0.200952572631652 no 706 0.183117704204183 881 4418754
SGTC_306 1672-3436 11.6 µM 0.901565032618914 0.201468033454113 no 707 0.18364398656184 925 6797378
SGTC_816 0325-0417 81.3 µM 0.900974156943984 0.201621822661566 no 708 0.18380103019017 899 68101
SGTC_408 cantharidin 100 µM 0.900131664483239 0.20184122259902 no 709 0.184025093445582 917 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_414 piperonyl butoxide 100 µM 0.898058770618099 0.202381649013409 no 710 0.184577109008638 896 5794 A potent inhibitor of cytochrome P450.
SGTC_2456 5770359 74.46 µM 0.893948377484021 0.203455829859873 no 711 0.185674756013965 951 3118787
SGTC_1 0258-0098 57.368 µM 0.890832559032453 0.204272357372713 no 712 0.186509502569522 805 6790032 YDR047W HEM12
SGTC_974 1326-0144 138 µM 0.890528434084757 0.204352160365817 no 713 0.186591103790241 937 5411856
SGTC_1930 st074634 34.3 µM 0.890445313404672 0.204373974627304 no 714 0.186613410143989 929 684253 YOR116C RPO31
SGTC_2407 paclitaxel 400 µM 0.888684221455453 0.204836482831624 no 715 0.187086406660333 926 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1246 0422-0085 105 µM 0.888281961862802 0.20494221384156 no 716 0.18719455004651 954 264295
SGTC_2910 7948405 25.97 µM 0.886108171730542 0.205514139973435 no 717 0.187779619994518 897 2971328
SGTC_1290 0986-0249 10.2 µM 0.8848780928309 0.205838194254197 no 718 0.188111192333144 923 53329
SGTC_1519 esterone 74 µM 0.884221793423371 0.206011214948461 no 719 0.188288248013375 910 698 A steroid.
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.882229922313425 0.206536861262451 no 720 0.188826241904142 777 6708630 An antioxidant.
SGTC_2401 5128683 200 µM 0.88146663553691 0.206738499760821 no 721 0.189032652440889 869 708373
SGTC_2428 5615643 7.78 µM 0.879561732056236 0.207242228816419 no 722 0.189548388663792 910 2253075
SGTC_1718 roemerine 11.9335 µM 0.878779110142144 0.207449394053047 no 723 0.189760527480753 927 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2323 6148992 148.28 µM 0.878049573801112 0.207642617377771 no 724 0.189958408268388 831 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3133 9127736 49.47 µM 0.878039598914519 0.207645260040073 no 725 0.189961114753841 933 27243420
SGTC_1394 3474-0001 65.7 µM 0.875520433939708 0.208313302381949 no 726 0.190645398437227 823 5017666 YIL048W NEO1
SGTC_1792 st045773 43.6 µM 0.874920933674958 0.208472466847876 no 727 0.190808463985514 912 2919270
SGTC_1695 st026914 34.495 µM 0.873886000728726 0.208747405318481 no 728 0.191090169615916 934 3289191
SGTC_1051 3253-3903 78 µM 0.868462675441063 0.210191646340177 no 729 0.192570548350436 1001 5509239
SGTC_1860 st056228 74.6 µM 0.866993398947765 0.210583925260732 no 730 0.19297281325915 924 688679
SGTC_2681 menadione 3.18 µM 0.866821215649671 0.210629924208797 no 731 0.193019987920976 946 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1239 0337-0584 35.4 µM 0.866504378857084 0.210714582892561 no 732 0.193106813047434 1008 914301 YML130C ERO1
SGTC_3140 9094243 49.47 µM 0.866225600722536 0.2107890888215 no 733 0.193183228395507 1036 19291112
SGTC_1723 st034307 2.5525 µM 0.862261191282547 0.211850283536829 no 734 0.194271901781611 963 867466
SGTC_1025 k007-0731 70 µM 0.862194507549087 0.211868160154056 no 735 0.194290245809789 940 6256118
SGTC_1475 4092-1048 11.7 µM 0.860010213867201 0.212454214722111 no 736 0.194891706135998 972 2881759
SGTC_2993 9054257 71.4286 µM 0.858508117000595 0.212857782217306 no 737 0.195305975171715 998 6470217 YGL055W OLE1
SGTC_2570 licareol 100 µM 0.858328775978862 0.212905995547463 no 738 0.195355472044648 888 443158
SGTC_1961 st076550 68.7 µM 0.856562970505389 0.213381047894184 no 739 0.195843228855781 901 1579337
SGTC_2710 st078562 53.7235 µM 0.854266992113664 0.213999655083313 no 740 0.19647853586356 990 17250908
SGTC_2650 prasterone 100 µM 0.853325324798249 0.214253670785713 no 741 0.196739459963586 930 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_560 2332-1943 155 µM 0.853124788586133 0.214307788275286 no 742 0.196795053103297 954 21177716
SGTC_1747 st037496 66.6 µM 0.851782934371427 0.214670110865223 no 743 0.19716728994841 966 723305
SGTC_2841 9004761 38.96 µM 0.851655485976587 0.214704542519068 no 744 0.197202666888445 932 2991039
SGTC_785 1270-0111 65.3 µM 0.850149908940194 0.215111534341291 no 745 0.19762087335807 1017 6741994
SGTC_2813 7971799 71.43 µM 0.850015576695915 0.215147869162548 no 746 0.197658213065318 936 2234054
SGTC_2723 salbutamol 83.58 µM 0.849627971898491 0.215252730311668 no 747 0.197765977663116 901 9884233 β2-adrenoceptor agonist
SGTC_2457 5731572 11.68 µM 0.849329102614157 0.215333605536471 no 748 0.197849095629029 1000 2865357
SGTC_2351 9026858 72.31 µM 0.84884284727162 0.215465225851029 no 749 0.197984372266703 926 1409300
SGTC_3014 9081533 49.47 µM 0.84866900871663 0.215512292049557 no 750 0.198032747848467 978 21367265
SGTC_2822 7994718 71.43 µM 0.846439733705187 0.216116389022551 no 751 0.198653740287888 880 1018011
SGTC_2399 5884133 200 µM 0.845765731088834 0.216299225573841 no 752 0.198841723100668 962 722445
SGTC_2775 cyproheptadine 69.59 µM 0.845290319967384 0.216428244089783 no 753 0.198974382188974 1029 2913 A selective serotonin reuptake inhibitor.
SGTC_900 1112-0045 141 µM 0.84433349007178 0.216688046474177 no 754 0.199241538389104 880 56211 YIL048W NEO1
SGTC_1292 0kpi-0043 232 µM 0.843868884438872 0.216814263131953 no 755 0.199371338674307 939 3333905
SGTC_2044 5102272 200 µM 0.843833208196673 0.216823956842202 no 756 0.199381307912342 912 592666
SGTC_1614 st002383 48.6 µM 0.842857987207567 0.217089034404854 no 757 0.199653936301925 979 1947235
SGTC_2250 alverine citrate 130 µM 0.842181667416026 0.217272976697312 no 758 0.199843136870195 984 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_620 0109-0052 432 µM 0.841587813236791 0.21743456457307 no 759 0.200009356553066 1007 493037
SGTC_616 4092-0450 108 µM 0.840971352697737 0.217602377013281 no 760 0.200181991650994 997 787165
SGTC_1665 st014639 11.4 µM 0.837665826734275 0.218503478823338 no 761 0.201109205627771 1044 981133 YIL048W NEO1
SGTC_3081 9117243 49.47 µM 0.835842443517322 0.21900145975069 no 762 0.201621772737771 992 45595589
SGTC_178 4092-0806 87.505 µM 0.835156029016145 0.219189094167923 no 763 0.201814931730896 989 2169044
SGTC_1503 4585-0012 61.3 µM 0.833950822283415 0.219518766206494 no 764 0.202154348286938 985 2922052
SGTC_608 k048-0125 159 µM 0.83025643646497 0.220531100703111 no 765 0.203196906369477 1019 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1255 0566-0045 221 µM 0.830229870974011 0.220538389844774 no 766 0.203204414771481 993 2788469
SGTC_1421 4029-0249 71.4 µM 0.829371327553772 0.220774034605343 no 767 0.203447160423555 1070 2894095
SGTC_2970 9090938 41.86 µM 0.827809062147719 0.221203199919384 no 768 0.203889320866647 1051 17217104
SGTC_1560 lithocholic acid 53.1 µM 0.827800531266142 0.221205544722047 no 769 0.203891736892021 956 9903 A bile acid which acts as a detergent.
SGTC_2533 agelasine 13.65 µM 0.82654148646529 0.221551762319924 no 770 0.204248497191011 1031 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1233 0325-0408 14.2 µM 0.825887754224002 0.221731650535614 no 771 0.204433883909284 997 12874
SGTC_1515 3460-0031 42.1 µM 0.822038013225506 0.222792679108819 no 772 0.205527631246957 958 2876596
SGTC_2845 9003024 42.97 µM 0.8210892441039 0.223054613404156 no 773 0.205797718087699 1026 2990173
SGTC_2517 totarol 10 µM 0.819677932297846 0.223444569827224 no 774 0.206199866712419 985 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_760 0568-0725 82.9 µM 0.818503958519147 0.223769243200052 no 775 0.206534741309476 1053 3916171
SGTC_1295 1013-0063 9.78 µM 0.817496560070836 0.224048062287442 no 776 0.206822357158937 1028 6826038
SGTC_990 3985-0011 41.3 µM 0.816819438339902 0.224235581075299 no 777 0.207015810998488 948 5399565 YGL099W LSG1
SGTC_1048 3161-0300 24.5 µM 0.816254669742723 0.224392053472402 no 778 0.207177247383917 1078 2165101
SGTC_2587 piperic acid 92.2 µM 0.814385745481641 0.224910291346664 no 779 0.207712001037577 950 5370536
SGTC_421 streptovitacin 30 mM 0.813963322418335 0.225027519845573 no 780 0.207832981457049 1021 91467 include heat shock
SGTC_3068 9116768 49.47 µM 0.812466789074565 0.225443107969123 no 781 0.208261917867244 994 41904888
SGTC_466 geldanamycin 89.2 µM 0.811687944150493 0.225659565416612 no 782 0.208485356899173 932 5288382 HSP90 inhibitor.
SGTC_2712 st079126 47.7 µM 0.811064244594778 0.225832989444538 no 783 0.208664388914995 1003 3152970
SGTC_2076 5212012 200 µM 0.807643689712498 0.226785437826421 no 784 0.209647864132981 941 604802
SGTC_727 3032-0951 202 µM 0.806339854670034 0.227149084466241 no 785 0.210023458148922 988 3652836
SGTC_2004 4023728 41.89 µM 0.806015819592913 0.227239510568106 no 786 0.210116863803542 1044 360084 YDR527W RBA50
SGTC_2765 myclobutanil 7.74 µM 0.805789683678884 0.227302628682906 no 787 0.210182063711127 1006 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2694 st077685 81.9 µM 0.805486529949522 0.227387259185872 no 788 0.210269488172363 1030 2838096
SGTC_2026 5148700 152 µM 0.805476398682651 0.227390087807276 no 789 0.210272410228848 1029 79838
SGTC_1403 3909-7815 62.9 µM 0.804271678489287 0.227726583610738 no 790 0.210620045184356 1000 6615483
SGTC_513 4245-1575 41.7 µM 0.802763352710664 0.228148275712126 no 791 0.211055763858836 1077 719745
SGTC_1408 3909-7976 48.8 µM 0.800353101550759 0.228823035233938 no 792 0.211753122495219 1076 24152374
SGTC_2254 7938975 95.19 µM 0.799474383728129 0.229069314186819 no 793 0.212007697188346 1073 2969277
SGTC_1447 4239-0816 81.9 µM 0.798807795474379 0.229256238554042 no 794 0.212200934835558 975 1341554
SGTC_732 3970-1727 52.7 µM 0.798449325113538 0.229356795998152 no 795 0.212304894570207 1042 1275699
SGTC_2569 tetrandrine 100 µM 0.796298061710643 0.22996078357607 no 796 0.212929405962014 938 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1396 3511-0007 98.6 µM 0.795499615408831 0.230185181254606 no 797 0.213161467292672 966 X1396
SGTC_1914 st062367 72.6 µM 0.792095804790512 0.23114317094481 no 798 0.21415240803733 995 978205
SGTC_691 1548-0686 185 µM 0.791639393226744 0.231271795207929 no 799 0.2142854852187 1051 46495133
SGTC_2889 9059656 51.95 µM 0.79079671447955 0.231509380776129 no 800 0.214531313747115 1085 3949838
SGTC_2020 4017018 200 µM 0.789624842070807 0.231840005553917 no 801 0.214873447929478 1065 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2804 7954240 19.48 µM 0.789044795811465 0.232003753450631 no 802 0.215042912620261 1050 828705
SGTC_104 0074-0074 590.992 µM 0.786896998536389 0.232610640048924 no 803 0.215671082349381 932 3943124
SGTC_1687 st020778 55.3625 µM 0.785849155924025 0.232907040904124 no 804 0.21597793228395 1117 4259299
SGTC_3088 9117578 49.47 µM 0.785751305930435 0.232934730215764 no 805 0.216006599555086 1116 678341
SGTC_1726 st035556 14.5795 µM 0.783100705943667 0.233685484658122 no 806 0.216783988329378 1074 5919439
SGTC_94 0334-0113 514.748 µM 0.783073965454247 0.233693065447804 no 807 0.216791839223714 1049 6795178
SGTC_1435 4092-0789 56.7 µM 0.78305623132529 0.233698093056321 no 808 0.216797045979466 1069 2248285
SGTC_689 0833-0039 98 µM 0.782780933827417 0.233776147322157 no 809 0.216877882838322 1079 5374726
SGTC_2873 9040596 71.43 µM 0.782410927175669 0.233881076944379 no 810 0.216986557020618 1091 6463863
SGTC_1797 st048695 56.8 µM 0.781944011837468 0.234013525989289 no 811 0.217123739035379 1054 592262 YIL048W NEO1
SGTC_279 1273-0055 2.93 µM 0.781855802411084 0.234038552865789 no 812 0.217149661023395 1129 2847562
SGTC_1993 st073995 70.8 µM 0.780739381811008 0.234355433043438 no 813 0.217477896555567 1062 3098394
SGTC_2687 chenodiol 100 µM 0.779414813539164 0.23473170076408 no 814 0.217867700205943 1034 5702181 A cholesterol synthesis inhibitor.
SGTC_978 1416-0512 87.4 µM 0.778290308150764 0.235051398945865 no 815 0.218198943904372 1097 6814003
SGTC_2085 5307070 144.047 µM 0.778094193666894 0.235107179142785 no 816 0.218256742730517 1017 2840351
SGTC_578 3460-0051 92 µM 0.777969637693741 0.235142609984229 no 817 0.218293456425071 1154 2876744
SGTC_27 0485-0001 32.618 µM 0.777431600268924 0.23529569247183 no 818 0.218452087378413 1012 2054479
SGTC_2944 9067346 25.62 µM 0.777136473532901 0.235379685335476 no 819 0.218539128538051 993 6473075
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.776441972577018 0.235577405101521 no 820 0.218744035134627 1096 23847180
SGTC_562 3772-2733 112 µM 0.776380864083529 0.235594806664466 no 821 0.21876206996642 1114 2876874 YIL048W NEO1
SGTC_950 1165-0508 94.1 µM 0.775263699888873 0.235913060922768 no 822 0.219091927262185 1035 6148369
SGTC_189 3970-0742 2.116 µM 0.774759237824109 0.236056848127625 no 823 0.219240969943599 1090 2891807
SGTC_384 k007-0144 5.16 µM 0.773280720581527 0.236478549035875 no 824 0.21967813156407 1075 6824886
SGTC_296 1222-0039 74.9 µM 0.771799826500537 0.236901343145834 no 825 0.220116497260759 1061 5984176
SGTC_2339 9000433 200 µM 0.770902759742429 0.237157656981894 no 826 0.220382285613998 1035 2988954
SGTC_1346 1488-2224 62.4 µM 0.770592947999479 0.237246213129468 no 827 0.220474121227611 1089 3722427
SGTC_2050 5263056 171 µM 0.770568124956984 0.237253309298436 no 828 0.220481480320232 1104 763468 YGL055W OLE1
SGTC_1115 galangin 695.678 nM 0.770231816879655 0.237349461255315 no 829 0.220581196808685 1153 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1594 piperine 70.1 µM 0.768641309817817 0.237804483974837 no 830 0.221053137471107 1066 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1994 st072947 40.9 µM 0.768167848076258 0.237940027372777 no 831 0.221193736176923 1055 5286565 YDL195W SEC31
SGTC_3303 9125618 40.5795 µM 0.76768523446836 0.238078234363484 no 832 0.221337105248607 1112 22695467
SGTC_2129 girgensonine 121.053 µM 0.765228614840414 0.238782422771296 no 833 0.222067711596801 1124 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_857 0438-0306 1.35 µM 0.765127690180899 0.238811377105153 no 834 0.222097756317365 1081 4686136
SGTC_2638 epoxomicin 18 µM 0.764663404632342 0.238944600990098 no 835 0.222236001477699 1079 9915668 A protesome inhibitor.
SGTC_2100 5377183 190 µM 0.762542393454351 0.239553728686287 no 836 0.222868175633799 1136 2844202
SGTC_1868 st057644 42.7 µM 0.760782218536528 0.240059871721361 no 837 0.223393578402336 1127 688665
SGTC_1748 st037455 53.6035 µM 0.758714322343638 0.240655244907478 no 838 0.224011733697 1080 580690
SGTC_2414 st077232 92.9 µM 0.758098475059886 0.240832710246796 no 839 0.224196016277681 1028 729801
SGTC_2670 beta-carotene 100 µM 0.757143973288095 0.241107904434219 no 840 0.22448180591044 1051 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1721 st082152 9.2685 µM 0.754495325298588 0.241872435685538 no 841 0.225275925658835 1087 5296051
SGTC_1931 st074438 57.1 µM 0.753287350936206 0.242221553271066 no 842 0.22563862909525 1101 2787313
SGTC_1853 st056710 91.2 µM 0.751846662994488 0.242638284477306 no 843 0.2260716382607 1155 269167
SGTC_2199 6590217 200 µM 0.749707206515529 0.243257856016718 no 844 0.226715533135351 1071 703109
SGTC_2145 5634607 200 µM 0.748961118054647 0.243474118921881 no 845 0.226940320472424 1088 308662
SGTC_1113 artemisinin 1.17947 µM 0.7482997695444 0.243665905717532 no 846 0.227139681748406 1137 2240 An anti-malaria and mitochondrial poison.
SGTC_3101 9120531 49.47 µM 0.747501829751651 0.24389741164084 no 847 0.227380349365405 1125 24824904
SGTC_3040 9091894 49.47 µM 0.747296884043205 0.243956891600806 no 848 0.227442186475666 1044 25236966
SGTC_693 4161-2696 114 µM 0.744922386435301 0.244646595686695 no 849 0.228159320487406 1103 805759
SGTC_325 2810-4341 181 µM 0.744073457759373 0.244893432766481 no 850 0.228416017910357 1135 774970
SGTC_1416 3966-0321 25.3 µM 0.743144309395 0.245163748311664 no 851 0.228697157918317 1151 582530 YLR208W SEC13
SGTC_3211 9128781 49.47 µM 0.742189708728093 0.245441635671365 no 852 0.228986201480165 1032 17194361
SGTC_2348 9022543 33.42 µM 0.741539515921909 0.245631005768317 no 853 0.22918319066958 1111 3162678 YDL140C RPO21
SGTC_1181 1222-0449 220 µM 0.737541106954983 0.246797274304061 no 854 0.230396677328921 1159 658318
SGTC_2628 lathosterol 100 µM 0.736143689417921 0.247205575448349 no 855 0.23082162849779 1187 6710616
SGTC_3346 9158254 43.5805 µM 0.735989654341023 0.24725060391628 no 856 0.230868496947835 1097 17639500
SGTC_2878 9043973 25.97 µM 0.735884993224613 0.247281201590641 no 857 0.230900345351559 1115 6465167
SGTC_1225 1216-0074 20.6 µM 0.735790878523355 0.247308717749459 no 858 0.230928986573229 1114 4241466
SGTC_1159 4092-0538 61.2 µM 0.734234036692006 0.247764126405679 no 859 0.231403056267447 1180 717301
SGTC_245 methotrexate 289.6 µM 0.734208027992289 0.247771738292789 no 860 0.23141098071249 1123 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_715 0868-0130 184 µM 0.734132827215999 0.247793747777867 no 861 0.23143389406712 1148 2876258
SGTC_543 3844-1095 191 µM 0.732425845382598 0.248293621538401 no 862 0.231954344263074 1150 4230703
SGTC_443 clozapine 122 µM 0.731845321135602 0.248463745096915 no 863 0.232131491595615 1053 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1379 2144-0755 36.5 µM 0.731796975458693 0.248477915676212 no 864 0.23214624770475 1188 5392327
SGTC_1674 st016616 23.6 µM 0.731014767028479 0.248707248273074 no 865 0.232385066580011 1144 625830
SGTC_1978 st071761 42 µM 0.730770638483758 0.248778846428687 no 866 0.23245963031802 1083 5147680
SGTC_3278 9139605 49.47 µM 0.728922948794929 0.249321093553482 no 867 0.233024398048444 1165 7958859
SGTC_1811 st050069 61.5 µM 0.728545069895605 0.249432068167887 no 868 0.233139994887025 1139 3877702
SGTC_631 k072-0230 41.5 µM 0.728302627838832 0.249503281821216 no 869 0.233214177036976 1158 5773147
SGTC_2592 piperlongumine 83.33 µM 0.727992687390712 0.249594337828339 no 870 0.23330903134697 1108 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_352 k048-0007 5.11 µM 0.727852267560755 0.249635596947139 no 871 0.233352012538788 1149 6811911
SGTC_1299 1079-1439 3.74 µM 0.72714170027283 0.249844436245063 no 872 0.23356957786899 1130 323161
SGTC_3161 9100388 49.47 µM 0.726986177534592 0.24989015752782 no 873 0.233617211661128 1193 25236368
SGTC_2700 st077718 96.8 µM 0.726539989175463 0.250021354657468 no 874 0.233753900947308 1125 904970
SGTC_3320 9137005 35.139 µM 0.725363790686261 0.250367378894819 no 875 0.234114440354675 1104 4908713
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.725326150548468 0.250378456386191 no 876 0.234125983246015 1062 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1214 0358-0031 63.7 µM 0.724873981392179 0.250511550058685 no 877 0.234264672071683 1134 4301366
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.724707929388772 0.250560436023971 no 878 0.234315614773868 1160 2724 A muscle relaxant with antifungal properties.
SGTC_185 k048-0037 25.491 µM 0.722755177736921 0.251135708114669 no 879 0.234915154639698 1176 6827589
SGTC_3207 9114163 49.47 µM 0.719292675275376 0.252157461320606 no 880 0.235980304025929 1198 849233
SGTC_1155 4088-0394 48.2 µM 0.718092480994552 0.252512138844865 no 881 0.236350132993959 1141 2326248
SGTC_2988 9073640 71.4286 µM 0.717505915822011 0.252685574261618 no 882 0.236530993743981 1172 9102229
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.712704373522801 0.254107648208189 no 883 0.238014354793026 1160 6708514
SGTC_1195 1502-0147 41.1 µM 0.712432677819559 0.254188241694739 no 884 0.238098443074371 1196 817940
SGTC_789 1309-1135 70.6 µM 0.71201244010559 0.254312923806937 no 885 0.238228536325961 1182 3092424
SGTC_167 3672-0051 66.205 µM 0.71033716049157 0.254810288111283 no 886 0.238747540525526 1141 3237971
SGTC_863 0466-0191 129 µM 0.709608045257682 0.255026909937283 no 887 0.238973614597594 1191 765160 YPR165W RHO1
SGTC_1662 st014054 52 µM 0.707563390791994 0.255634895040753 no 888 0.239608216964522 1189 2838777
SGTC_752 1896-0090 130 µM 0.705832600049377 0.25615014264052 no 889 0.240146123078538 1170 772567
SGTC_2424 5537928 59.2 µM 0.703776482760071 0.256762941374933 no 890 0.240785990710326 1236 5382802
SGTC_2887 9044784 58.44 µM 0.703638267102467 0.256804162092251 no 891 0.240829036939413 1207 6465546
SGTC_379 3970-0972 5.9 µM 0.703428314609945 0.256866783818603 no 892 0.240894433077054 1176 2898042 YBL034C STU1
SGTC_2867 9039098 71.43 µM 0.70298298045606 0.25699963823199 no 893 0.241033178016463 1179 6463460
SGTC_3352 9151559 45.5865 µM 0.702380869296299 0.257179320000776 no 894 0.24122083628616 1163 17159339
SGTC_378 3970-0959 8.33 µM 0.701596855724907 0.25741338287186 no 895 0.241465306530853 1176 6615653
SGTC_2802 7925815 54.55 µM 0.698281923223863 0.258404259419259 no 896 0.24250045091702 1186 1262923
SGTC_2473 5854593 8.94 µM 0.697536193504016 0.258627439722457 no 897 0.242733648515604 1141 2872951
SGTC_3104 9120930 49.47 µM 0.696131660278111 0.259048056084088 no 898 0.243173190379782 1203 17014836
SGTC_1638 st008370 60.6 µM 0.695587381250848 0.259211146682497 no 899 0.243343635480889 1209 24207134
SGTC_1575 cyproterone acetate 48 µM 0.695451988415637 0.259251724737199 no 900 0.243386044798529 1158 9880 An androgen receptor antagonist and liver toxin.
SGTC_2350 9023895 38.85 µM 0.695290860517781 0.259300020024317 no 901 0.243436520355741 1200 2997209
SGTC_3229 9132204 49.47 µM 0.694712826769111 0.259473313841245 no 902 0.243617644003339 1200 17682924
SGTC_2124 5246320 200 µM 0.694314651819727 0.259592720992101 no 903 0.243742452217998 1181 579342
SGTC_1463 k081-0032 34.1 µM 0.693316108689348 0.259892294980183 no 904 0.244055598019447 1052 977755
SGTC_1960 st011366 51.8 µM 0.691743849273127 0.260364351406332 no 905 0.244549102288656 1228 3972846
SGTC_1303 1160-0052 261 µM 0.689351324821713 0.261083531366134 no 906 0.245301103323698 1221 3562476
SGTC_2259 7964009 200 µM 0.688709663263534 0.26127658488727 no 907 0.245502996947463 1215 313134
SGTC_2534 helenine 20.12 µM 0.687295624896876 0.261702278312726 no 908 0.245948227651248 1213 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1969 st069479 40.1 µM 0.686925732646644 0.261813692328974 no 909 0.246064765099898 1180 3895485
SGTC_898 1000-0849 28.3 µM 0.686902377825166 0.26182072777368 no 910 0.246072124213251 1195 6751807
SGTC_175 3793-3120 23.7 µM 0.686597504266122 0.261912577278819 no 911 0.246168200819415 1205 5322297
SGTC_3355 9151058 44.0485 µM 0.686594764525956 0.26191340275747 no 912 0.246169064301116 1225 17015728
SGTC_1483 3453-0561 55.9 µM 0.686571810657896 0.261920318767925 no 913 0.246176298717033 1210 4546991
SGTC_260 nsc-65238 3.989 µM 0.685823017152742 0.262145981920539 no 914 0.24641235995646 1168 3246252
SGTC_1705 st027868 56.3335 µM 0.684894154226374 0.262426050799258 no 915 0.246705357560168 1222 292948
SGTC_814 3342-0569 96 µM 0.683535052965279 0.262836120174135 no 916 0.247134404159777 1249 4346283
SGTC_541 4513-1321 94 µM 0.683082354340565 0.262972781565563 no 917 0.247277402451826 1179 747515
SGTC_1419 3993-2473 62.6 µM 0.6820890742174 0.263272761801123 no 918 0.247591314403619 1246 704026
SGTC_3170 9103054 49.47 µM 0.681382525716373 0.263486252627443 no 919 0.247814738435611 1180 16432970
SGTC_842 0271-0008 11.1 µM 0.681380930978968 0.263486734593518 no 920 0.247815242843529 1258 1221709
SGTC_1400 3771-8998 51.5 µM 0.681067191246292 0.263581562659491 no 921 0.247914487900971 1171 670767
SGTC_651 3253-0966 34.4 µM 0.680909713685009 0.263629166931904 no 922 0.247964310656107 1243 781462
SGTC_2585 alliin 100 µM 0.680417055855611 0.263778121977757 no 923 0.248120212252325 1293 87310 A garlic compound which reacts with lipids.
SGTC_5 0352-0601 109.883 µM 0.678386085909518 0.264392638373292 no 924 0.248763464464928 1147 762456
SGTC_2363 9053361 176 µM 0.678327077829175 0.264410503504849 no 925 0.248782166868149 1263 6469797 YMR079W SEC14
SGTC_1000 4048-0884 8.67 µM 0.677689786289077 0.264603487363116 no 926 0.248984201871906 1221 13040088
SGTC_1125 tnp00248 1.32998 µM 0.676596250242889 0.264934797507785 no 927 0.249331079447582 1316 24207736
SGTC_418 lividomycin a 100 µM 0.674657954769391 0.265522563146701 no 928 0.249946551559417 1243 72394 An antibiotic.
SGTC_184 1494-0393 24.714 µM 0.673892221730039 0.265754944964366 no 929 0.250189918805336 1224 3090647
SGTC_949 1165-0505 146 µM 0.672684052278713 0.266121805286747 no 930 0.250574157753061 1242 6244267
SGTC_825 1988-2224 89.6 µM 0.671948654903048 0.266345233983808 no 931 0.250808192083312 1235 1180859
SGTC_1092 toremifene 6.32 µM 0.671888091681947 0.266363638553295 no 932 0.250827471000263 1247 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1250 0485-0349 40.2 µM 0.671399848440725 0.266512034392049 no 933 0.250982920726729 1224 6842794 YDL195W SEC31
SGTC_1070 indatraline 8.81 µM 0.671276275939629 0.26654959944226 no 934 0.251022272542063 1219 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1777 st045864 34.765 µM 0.670023771381412 0.266930501845791 no 935 0.251421318333559 1247 4691462
SGTC_1395 3486-0190 4.35 µM 0.669969510475044 0.266947009482113 no 936 0.251438613338508 1265 6748079
SGTC_1029 k015-0030 64.7 µM 0.669946854969088 0.266953902052804 no 937 0.251445834691963 1260 2208316
SGTC_119 0121-0043 24.815 µM 0.669784574469144 0.267003275893988 no 938 0.251497564167598 1298 1092378
SGTC_2961 9083290 32.55 µM 0.668920230981496 0.267266330068624 no 939 0.251773182036953 1210 17741490
SGTC_1103 duloxetine 36.1 µM 0.668399800300301 0.267424780922337 no 940 0.251939211465682 1307 60835 A selective serotonin reuptake inhibitor.
SGTC_422 cantharidin 155 µM 0.667679293211255 0.267644225419404 no 941 0.252169165236266 1217 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_250 brefeldin a 552.239 µM 0.665706395054102 0.268245574223074 no 942 0.252799392562071 1150 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_480 am 92016 50 µM 0.663755362365588 0.268840926100147 no 943 0.253423449682263 1177 2129 K+ channel blocker.
SGTC_835 0312-0010 67.2 µM 0.663344462214958 0.268966395611126 no 944 0.253554983299361 1217 1626196
SGTC_1873 rapamycin 2 nM 0.663280449488807 0.26898594472236 no 945 0.253575477699182 1243 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_896 0964-0007 44.5 µM 0.6615545515403 0.269513292545992 no 946 0.254128371349267 1235 6756758
SGTC_3321 9137793 26.8275 µM 0.660413503345954 0.269862223918229 no 947 0.254494254521773 1247 4904192
SGTC_1203 3992-3522 103 µM 0.659380363302675 0.270178352057242 no 948 0.25482577430634 1424 5322312
SGTC_1201 1889-3372 45.9 µM 0.65711353210515 0.270872622890718 no 949 0.255553959214292 1190 5392199
SGTC_72 0744-0168 198.391 µM 0.657038358703041 0.2708956617723 no 950 0.255578126129091 1199 677577
SGTC_207 4185-0010 4.486 µM 0.656186275029286 0.271156873740133 no 951 0.255852139337992 1302 3761753
SGTC_1294 1000-1494 117 µM 0.655911569032403 0.271241113470429 no 952 0.255940512011132 1235 712797 YDL207W GLE1
SGTC_1016 4226-1401 38 µM 0.655471216009302 0.271376176758513 no 953 0.256082206406276 1250 2901613
SGTC_2803 7707263 71.43 µM 0.653715315603887 0.271915072398479 no 954 0.256647617054073 1258 2199229
SGTC_737 1950-0117 57.9 µM 0.652864860743088 0.272176272965719 no 955 0.256921702201891 1223 5393513
SGTC_1340 1486-1359 257 µM 0.651999478754605 0.272442186061225 no 956 0.257200754327762 1235 4309068
SGTC_2789 5281112 71.43 µM 0.651109079293138 0.272715921086875 no 957 0.257488038006047 1262 765948
SGTC_289 k017-0060 526 µM 0.650670586928673 0.272850776693287 no 958 0.257629576974354 1238 5512909
SGTC_1683 st010134 710 nM 0.649840069544525 0.273106287778368 no 959 0.25789776660712 1270 3818134
SGTC_826 1683-5028 118 µM 0.645836620252946 0.274339621631642 no 960 0.259192584589498 1290 722377
SGTC_2256 7954252 200 µM 0.644001434226352 0.274905901044863 no 961 0.259787251979728 1231 2972920
SGTC_2866 9034245 58.44 µM 0.643627181578852 0.275021454054253 no 962 0.259908609891653 1260 6462273
SGTC_70 0141-0289 43.283 µM 0.643602787866617 0.275028986606671 no 963 0.259916520990939 1309 352408
SGTC_1328 1441-0025 69.2 µM 0.641912610037593 0.275551145195156 no 964 0.260464963080131 1216 4562601
SGTC_1604 st002052 72.4 µM 0.641701004546272 0.275616552299719 no 965 0.260533668434034 1306 6254834 YHR062C RPP1
SGTC_2298 7976326 193.81 µM 0.640567113156483 0.275967167303053 no 966 0.260901986066666 1170 2235818
SGTC_895 0964-0006 13.7 µM 0.637723770901948 0.276847330518716 no 967 0.261826754449212 1261 6738897
SGTC_3226 9131256 49.47 µM 0.637644828866959 0.276871786811283 no 968 0.261852453516073 1191 17178073
SGTC_3164 9100705 49.47 µM 0.637445066751215 0.276933677967271 no 969 0.261917490554068 1307 17174235
SGTC_2415 st077333 57.7 µM 0.637414258566326 0.27694322369421 no 970 0.261927521586962 1359 2766255
SGTC_2732 terfenadine 20 µM 0.635883477957561 0.277417729427761 no 971 0.262426186126432 1284 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_301 4119-0100 24.5 µM 0.635870060568185 0.277421890257164 no 972 0.262430559100814 1283 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2452 5863136 48.41 µM 0.635085566959392 0.277665220418058 no 973 0.262686304867181 1257 2184096
SGTC_1119 parthenolide 318.541 nM 0.633799454140237 0.278064365646789 no 974 0.263105854740221 1391 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2564 betulinic acid 100 µM 0.633601486264676 0.278125829845171 no 975 0.263170465315135 1361 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_848 0368-0089 85.6 µM 0.633470528888215 0.278166492558882 no 976 0.263213210195456 1269 762535
SGTC_1132 3456-3614 2.5 µM 0.632262477882896 0.278541733204303 no 977 0.263607688847687 1364 3125502
SGTC_2701 st077767 14.721 µM 0.631932652723085 0.278644225192331 no 978 0.26371544280912 1295 5721188
SGTC_1572 epiandrosterone 68.9 µM 0.631691253921283 0.27871925064303 no 979 0.263794322093522 1240 441302 A steroid.
SGTC_1345 1488-0192 31.4 µM 0.630803386375747 0.278995279677671 no 980 0.264084544465445 1298 658348
SGTC_2093 5331342 194.4 µM 0.628708907349799 0.279646958305897 no 981 0.264769822798054 1296 33839
SGTC_801 0866-0028 10.1 µM 0.627744099707943 0.27994739802064 no 982 0.265085795530475 1318 6849771
SGTC_2402 5553605 200 µM 0.626872637334226 0.280218904612186 no 983 0.265371362406336 1353 6758546
SGTC_131 0141-0277 33.849 µM 0.626814958916856 0.280236878987861 no 984 0.265390268380162 1301 1547771
SGTC_2096 5468907 200 µM 0.626590299794339 0.28030689503076 no 985 0.265463914217004 1306 759785
SGTC_427 1354-0053 47.3 µM 0.626180172064634 0.280434735059865 no 986 0.265598385528343 1374 6813657
SGTC_2444 5485484 36.41 µM 0.625299197612161 0.280709437100318 no 987 0.26588735325162 1378 6790631
SGTC_834 0312-0008 75.7 µM 0.624982225305407 0.280808306005663 no 988 0.265991362042093 1315 6385573 YIL048W NEO1
SGTC_714 4296-0578 26.1 µM 0.623814113343834 0.281172804737153 no 989 0.266374834926027 1301 1589775
SGTC_644 1498-1197 63.3 µM 0.623579722935074 0.281245971651588 no 990 0.266451815313491 1345 6741615
SGTC_533 1222-0222 6.71 µM 0.62296056672832 0.281439290611225 no 991 0.266655217699579 1401 3982874
SGTC_1876 myriocin 605 nM 0.62235364603098 0.281628851489841 no 992 0.266854676690713 1382 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2780 5215298 71.43 µM 0.622045411982984 0.281725146478033 no 993 0.266956003874836 1296 2834131
SGTC_870 0573-2213 57.6 µM 0.621174113335596 0.281997433542651 no 994 0.267242534921528 1298 3916321
SGTC_2497 7-hydroxyflavone 100 µM 0.618167983305636 0.28293784252668 no 995 0.268232306271637 1329 5281894
SGTC_291 SEC14.278 35.5 µM 0.617544134174933 0.283133190030104 no 996 0.268437940081213 1317 1068044
SGTC_922 1866-0035 480 µM 0.617044856560244 0.283289576738542 no 997 0.268602569581531 1323 3156169
SGTC_806 3966-4455 5.86 µM 0.616958196134531 0.28331672525195 no 998 0.268631149758187 1240 714982
SGTC_538 2922-0838 53.3 µM 0.613837814699969 0.284295091908019 no 999 0.269661253081618 1367 777039
SGTC_1235 benzylparaben 21.5 µM 0.611018882962369 0.285180327886825 no 1000 0.270593539696741 1311 7180
SGTC_329 k048-0121 21.3 µM 0.609477916518402 0.285664796006182 no 1001 0.271103853026731 1333 6832902
SGTC_1179 1021-1431 9.29 µM 0.607004767596993 0.286443152763047 no 1002 0.271923874089121 1340 2840958
SGTC_1202 1988-0068 29.6 µM 0.606278844726063 0.286671808270891 no 1003 0.272164802076966 1274 2850480
SGTC_1352 1496-0991 99 µM 0.605581167262559 0.286891648404024 no 1004 0.272396455590038 1325 3000039
SGTC_2486 5283202 22.39 µM 0.602879397119556 0.28774373656588 no 1005 0.2732944614577 1290 1377751
SGTC_1267 0828-0272 9.49 µM 0.602576180667288 0.287839439984292 no 1006 0.273395335031177 1406 745334
SGTC_742 0kpi-0133 140 µM 0.602384373048346 0.287899987485093 no 1007 0.273459154807042 1389 2728852
SGTC_3242 9133940 49.47 µM 0.599186619218341 0.2889103004342 no 1008 0.274524222356154 1382 17248444
SGTC_3001 9076041 71.4286 µM 0.597116904683604 0.289565103641423 no 1009 0.275214666141372 1339 16004211
SGTC_1036 k216-0215 33.5 µM 0.595801907039489 0.289981495965632 no 1010 0.275653784796691 1332 622330
SGTC_290 2043-6722 48.1 µM 0.59522671653739 0.290163717515742 no 1011 0.275845967039676 1350 773758 YLR208W SEC13
SGTC_1023 4482-3888 16 µM 0.594965379892964 0.290246527232258 no 1012 0.275933306399057 1401 3303168
SGTC_1849 st056239 19.2 µM 0.593356652303219 0.290756528240426 no 1013 0.276471246151234 1252 5393181
SGTC_2349 9023730 187.07 µM 0.59227791769284 0.291098744683671 no 1014 0.276832250225667 1416 4126287
SGTC_3074 9116018 49.47 µM 0.586036432939059 0.293082468928474 no 1015 0.278925515991478 1402 17027303
SGTC_556 4058-0063 51.5 µM 0.584424276694397 0.293595875890704 no 1016 0.279467448762927 1394 6615692
SGTC_3206 9114350 49.47 µM 0.584261685990679 0.293647677601083 no 1017 0.279522132651747 1308 17087243
SGTC_1763 st044482 94.5 µM 0.58358248128086 0.293864119264624 no 1018 0.279750624725962 1385 88505
SGTC_2649 anisomycin 9.56 µM 0.583545637554661 0.293875862337409 no 1019 0.279763021959089 1325 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_940 3232-1287 54.8 µM 0.580689011069728 0.294787005012672 no 1020 0.280725034617721 1344 1585493 YIL048W NEO1
SGTC_160 3453-0671 289.699 µM 0.579692039420399 0.295105302993752 no 1021 0.281061156302039 1305 5322268
SGTC_1793 st048256 72.231 µM 0.579599203319365 0.295134950349099 no 1022 0.281092465205956 1308 672022
SGTC_1799 st045822 46.1415 µM 0.578329492759054 0.29554057200254 no 1023 0.281520843132626 1354 3674992
SGTC_614 0462-0418 107 µM 0.577766779236251 0.295720418365073 no 1024 0.281710793400979 1274 5188303
SGTC_192 3455-0609 60.9 µM 0.577646507799721 0.295758864305372 no 1025 0.281751400387876 1394 3769639
SGTC_1161 k007-0610 110 µM 0.577333597300094 0.295858899963222 no 1026 0.281857060905391 1420 5843850
SGTC_2842 9000675 19.48 µM 0.576418444809809 0.296151558014708 no 1027 0.282166190064163 1316 2989072
SGTC_1240 0356-0016 42.1 µM 0.57530537477353 0.296507687334525 no 1028 0.282542393570673 1403 4305613
SGTC_525 k781-2675 26.7 µM 0.574939840355066 0.296624683702605 no 1029 0.282665992131248 1404 3651118 YDL195W SEC31
SGTC_2411 st077133 39.94 µM 0.574098478336557 0.296894058221805 no 1030 0.282950581504046 1521 1403142 YNL221C POP1
SGTC_1116 jasmonic acid 1.58368 µM 0.57264770664972 0.297358807004495 no 1031 0.283441625607746 1425 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2655 perillic acid 100 µM 0.572193139219322 0.297504494174093 no 1032 0.283595567491818 1342 5702197 An apoptosis inducer.
SGTC_2119 5528445 120.635 µM 0.571128481759822 0.29784584041441 no 1033 0.283956276580888 1441 791935
SGTC_366 0181-0206 4.31 µM 0.568286776520839 0.298757810009104 no 1034 0.284920128272027 1463 274874
SGTC_1828 st055811 49 µM 0.568010363590674 0.298846585066758 no 1035 0.285013965431805 1359 5877589
SGTC_1356 1502-0781 85.8 µM 0.564737532373796 0.299898624399954 no 1036 0.286126150783417 1357 567702
SGTC_669 0108-0021 26.2 µM 0.564700193192091 0.299910636606454 no 1037 0.286138851405725 1618 17201
SGTC_2893 9048488 25.97 µM 0.564274484546857 0.30004760465589 no 1038 0.286283671705897 1311 6467338
SGTC_807 1315-0151 48 µM 0.563289641329465 0.300364577789735 no 1039 0.286618835312432 1434 4011080
SGTC_1901 st060216 58.6 µM 0.562268482572883 0.300693398815086 no 1040 0.286966554283167 1384 688792
SGTC_575 k072-0246 11.9 µM 0.560829120006049 0.301157160379806 no 1041 0.287457016630506 1408 6796779
SGTC_456 gingerol 170 µM 0.558456046719672 0.301922465618118 no 1042 0.288266505104404 1443 442793 A herb.
SGTC_2882 9058044 58.44 µM 0.557992360711002 0.302072104212375 no 1043 0.288424800352411 1316 18076804
SGTC_1986 st071812 45 µM 0.557385950684474 0.302267852276503 no 1044 0.288631881188129 1408 11838594
SGTC_2952 9073731 13.78 µM 0.557282606653533 0.302301217219153 no 1045 0.288667178762472 1372 16457353
SGTC_3283 9109332 35.8195 µM 0.555996655932079 0.302716528541276 no 1046 0.28910657041595 1344 17027281
SGTC_1079 idarubicin 2.36 µM 0.55291949555012 0.303711365832431 no 1047 0.290159268563421 1390 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3339 9145883 14.936 µM 0.552844486829444 0.303735634148972 no 1048 0.290184951494246 1392 2030670
SGTC_1187 1391-0724 117 µM 0.551409738449486 0.304199999020682 no 1049 0.290676413188804 1425 6997986
SGTC_2753 fluvastatin 17.09 µM 0.55105340674482 0.304315376911703 no 1050 0.290798532117041 1439 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3051 9093778 49.47 µM 0.548797681581603 0.305046217708673 no 1051 0.291572150763408 1417 17217378
SGTC_3086 9117350 49.47 µM 0.548608738728099 0.305107469369338 no 1052 0.291636993731164 1351 2679265
SGTC_927 2425-1185 123 µM 0.545369959654924 0.306158267367747 no 1053 0.292749548446252 1372 730375
SGTC_2307 7538926 6.34 µM 0.543989614483946 0.30660659601573 no 1054 0.293224309791402 1409 96582
SGTC_2171 5739187 198.077 µM 0.54298069203053 0.3069344717855 no 1055 0.293571548180208 1360 2262761
SGTC_1710 st031758 61.5 µM 0.542369325083383 0.307133226668976 no 1056 0.29378205345694 1500 5394341
SGTC_2261 9010538 184.68 µM 0.541263279832136 0.307492945050273 no 1057 0.294163063248167 1350 6457250
SGTC_1024 4507-0395 26 µM 0.540423833136294 0.307766081411459 no 1058 0.294452387647925 1460 4201836
SGTC_258 haloperidol 50.781 µM 0.540253443014801 0.307821535395528 no 1059 0.2945111304827 1368 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2897 9048598 12.99 µM 0.538621530508285 0.308352868503478 no 1060 0.295074014112383 1396 6467404
SGTC_2953 9074162 66.49 µM 0.5369726108497 0.308890147026632 no 1061 0.295643266638032 1508 16451992
SGTC_2052 5265182 7.135 µM 0.536581817926616 0.309017541723612 no 1062 0.295778253085535 1521 1239884
SGTC_1243 0416-0003 5.65 µM 0.534640735334113 0.309650656013879 no 1063 0.296449154879679 1423 2141977
SGTC_1946 st076057 65.1 µM 0.534061224768448 0.309839782045847 no 1064 0.296649587847718 1356 953009
SGTC_1857 st056007 79.3 µM 0.532882776168766 0.310224529591163 no 1065 0.297057364394186 1427 619834
SGTC_2909 7941780 10.49 µM 0.532620408404991 0.310310217420436 no 1066 0.297148185938828 1453 1243215
SGTC_294 k038-0071 157 µM 0.531070801914119 0.310816520048693 no 1067 0.29768485832247 1440 24152826
SGTC_2375 9072683 200 µM 0.529776403956385 0.311239713236777 no 1068 0.298133483518257 1561 16798029
SGTC_2084 5306078 60.6385 µM 0.52823153362002 0.311745123132861 no 1069 0.298669322686509 1451 679340
SGTC_1226 3909-7979 35.4 µM 0.528159676868289 0.311768639969977 no 1070 0.298694256896253 1504 6615510
SGTC_1640 st009078 66.4 µM 0.528096244640953 0.311789400318272 no 1071 0.298716268592179 1511 690618
SGTC_1080 nisoldipine 24.4 µM 0.52708531447526 0.312120342195091 no 1072 0.29906717219955 1426 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2987 9018338 71.43 µM 0.526925445772936 0.312172691307548 no 1073 0.299122681301065 1455 5055682
SGTC_2582 agaric acid 100 µM 0.526813534926273 0.312209338845174 no 1074 0.299161541411229 1322 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3219 9131112 49.47 µM 0.525889057294466 0.312512149351388 no 1075 0.299482646180281 1407 17612988 YMR079W SEC14
SGTC_2235 salicylic acid 500 µM 0.525583360798255 0.31261230739971 no 1076 0.299588860076581 1468 338 A COX inhibitor and kinase inhibitor.
SGTC_1606 st000094 49.2 µM 0.524117380829523 0.313092811618979 no 1077 0.300098450170179 1488 1242210
SGTC_565 1418-0001 44.5 µM 0.52237860122135 0.313663143097914 no 1078 0.30070337603726 1496 2862145
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.521466980555047 0.3139623390145 no 1079 0.301020750932282 1423 803109
SGTC_380 3970-0968 6 µM 0.521361633373115 0.313996922081922 no 1080 0.301057436609672 1402 2891601
SGTC_528 3492-0019 172 µM 0.520974377969548 0.314124063201439 no 1081 0.301192310183577 1473 2869262
SGTC_1679 SEC14.276 6.7 µM 0.520872701608945 0.314157448565555 no 1082 0.301227726606357 1505 1005053 YMR079W SEC14
SGTC_92 0063-0024 660.874 µM 0.52065650139878 0.314228442812444 no 1083 0.301303040788397 1457 3594437
SGTC_143 4032-1194 15.74 µM 0.519437219128788 0.314628950450044 no 1084 0.301727941156944 1453 1806963
SGTC_318 1488-0629 67.2 µM 0.517923790114434 0.315126382376115 no 1085 0.302255721346734 1427 3662576
SGTC_3354 9151612 71.43 µM 0.516743982198511 0.31551439287216 no 1086 0.302667444502115 1534 27261949
SGTC_3315 9136395 68.55 µM 0.516286963866068 0.315664749933467 no 1087 0.302826999846426 1505 16876844
SGTC_78 0336-0123 156.75 µM 0.513077456765176 0.316721522435806 no 1088 0.303948570011598 1422 6765896
SGTC_356 1634-0012 32.5 µM 0.512976632571309 0.316754744433733 no 1089 0.303983833264857 1488 735457
SGTC_41 0478-0632 82.643 µM 0.511977209682463 0.317084138397558 no 1090 0.30433347993825 1494 3750424
SGTC_3215 9129942 49.47 µM 0.510842976388736 0.31745813938398 no 1091 0.304730506615328 1468 17682944
SGTC_1684 st024538 14.6195 µM 0.509418158948062 0.317928221470597 no 1092 0.305229575323936 1461 6732859
SGTC_3216 9129716 49.47 µM 0.508138772632784 0.318350572447253 no 1093 0.305678012884471 1403 8056934
SGTC_1498 4478-3555 97.6 µM 0.507998850178922 0.318396777983609 no 1094 0.305727074789849 1493 3437919
SGTC_2232 chlorophetanol 41.5365 µM 0.507973628131244 0.318405107170674 no 1095 0.305735918928825 1552 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3345 9148410 3.559 µM 0.506849100339249 0.318776558126673 no 1096 0.306130350933609 1542 4903596
SGTC_2733 amorolfine 100 µM 0.505471845896372 0.319231737188604 no 1097 0.306613734009935 1526 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_798 1287-0182 476 µM 0.504858877377477 0.319434409424653 no 1098 0.30682897946161 1576 1649755
SGTC_1653 st012112 65 µM 0.504215741502854 0.319647114215947 no 1099 0.307054889875308 1503 720429
SGTC_613 3914-0030 117 µM 0.504055182681081 0.31970022520937 no 1100 0.307111299824674 1401 1145395
SGTC_2048 5246248 200 µM 0.50218953845452 0.320317629504944 no 1101 0.307767100573231 1499 677046
SGTC_1843 st055809 45.5 µM 0.502149734638612 0.320330807352197 no 1102 0.307781098889832 1458 16413835
SGTC_2028 5153890 36.43 µM 0.502099563037728 0.320347417984259 no 1103 0.307798743776468 1462 2830968 YPR165W RHO1
SGTC_672 1441-0018 53.7 µM 0.500907986129437 0.320742026683183 no 1104 0.308217940889639 1433 251141
SGTC_46 0329-0187a 2.197 µM 0.498112153472822 0.321668703841732 no 1105 0.309202497421189 1554 46494817
SGTC_2676 harmalol 100 µM 0.497930302921197 0.321729016632496 no 1106 0.309266583944606 1534 5459187 A monoamine oxidase inhibitor
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.496860978373176 0.322083765197432 no 1107 0.309643545302736 1471 688662
SGTC_502 l-744,832 89.3 µM 0.492731795045688 0.323455142098853 no 1108 0.311101054346258 1562 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_79 0052-0007 94.094 µM 0.491793176015132 0.323767210241214 no 1109 0.31143278054971 1577 2801472
SGTC_1932 st074806 40.9 µM 0.491188567279782 0.32396829368082 no 1110 0.311646542143688 1567 17251235
SGTC_1296 1068-0102 11.9 µM 0.489474350327768 0.324538694700471 no 1111 0.312252954718919 1542 767053
SGTC_1771 st048882 4.1505 µM 0.489057416035682 0.324677490766753 no 1112 0.312400524262344 1429 4580403
SGTC_2081 5214970 32.255 µM 0.488753692436322 0.32477861469329 no 1113 0.312508043008861 1575 2063512
SGTC_1087 pterostilbene 9.05 µM 0.48853863923154 0.324850223869097 no 1114 0.31258418191537 1598 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1050 3232-1156 69.3 µM 0.486178499826609 0.325636536248657 no 1115 0.313420306869302 1456 700529
SGTC_2430 5571206 200 µM 0.485619983689046 0.325822727205382 no 1116 0.313618312592014 1568 1731771
SGTC_488 nitrendipine 139 µM 0.485276618260349 0.325937215544902 no 1117 0.313740069525197 1541 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1881 5652484 16 µM 0.484854214180301 0.326078080257836 no 1118 0.313889881292835 1581 2255129
SGTC_943 3253-1379 105 µM 0.484158601330015 0.326310109626636 no 1119 0.314136657400232 1587 668464
SGTC_247 mechlorethamine 29.705 µM 0.482729557339555 0.3267869939494 no 1120 0.314643886753298 1495 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2885 9057732 51.95 µM 0.482413676295302 0.326892444412953 no 1121 0.314756053826119 1505 6471414
SGTC_1610 st001799 48.1 µM 0.482057318864299 0.327011423691834 no 1122 0.31488261429034 1453 621897
SGTC_2398 5228213 48.84 µM 0.481384793968144 0.327236011678109 no 1123 0.315121520965536 1634 80771 YMR134W ERG29
SGTC_1218 1348-1416 30.7 µM 0.479053344248275 0.328015077367259 no 1124 0.315950339857676 1504 6787668
SGTC_3301 9125354 19.7965 µM 0.477920725524271 0.328393818126038 no 1125 0.316353314722455 1487 41905162
SGTC_2361 9034121 116 µM 0.476260882675287 0.328949178046711 no 1126 0.316944264933173 1511 6496917
SGTC_1798 st045719 60.953 µM 0.47505919094964 0.329351482959764 no 1127 0.317372392326512 1465 3980186
SGTC_2943 9068529 45.32 µM 0.473133544057493 0.329996567098678 no 1128 0.318058953206047 1498 3270634
SGTC_1767 st044992 70.3 µM 0.47249325390157 0.330211173939104 no 1129 0.318287377911781 1453 9600693
SGTC_2935 9038016 29.96 µM 0.472009077372984 0.330373493084776 no 1130 0.318460154687263 1510 6463195
SGTC_767 0929-0023 86 µM 0.470796575637059 0.330780121706812 no 1131 0.318893005082702 1521 1204563
SGTC_1332 1480-0653 17.5 µM 0.47029013176205 0.33095002358484 no 1132 0.319073873437072 1534 5749438
SGTC_3243 9134147 49.47 µM 0.470056149935856 0.331028531610749 no 1133 0.319157450868139 1570 24282180
SGTC_2816 7982706 58.44 µM 0.470011610879465 0.33104347666197 no 1134 0.31917336109368 1488 2981853
SGTC_730 1436-0052 41.2 µM 0.469891424115692 0.331083806595181 no 1135 0.319216295827719 1527 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_124 0136-0217 7.121 µM 0.468624693602412 0.331508990452932 no 1136 0.319668961721822 1622 3976905
SGTC_2674 ligustilide 100 µM 0.468123827670566 0.331677168336669 no 1137 0.319848020245225 1525 5319022 A signalling regulator.
SGTC_3172 9105863 49.47 µM 0.467327800869591 0.331944523450861 no 1138 0.320132684542685 1560 2348785
SGTC_1307 1187-1599 12.2 µM 0.466371714388204 0.332265749653284 no 1139 0.320474727200443 1511 1538471
SGTC_3268 9137683 49.47 µM 0.465719930332724 0.33248480691883 no 1140 0.320707992260192 1539 1953228
SGTC_3273 9137859 49.47 µM 0.46568808528544 0.332495511146656 no 1141 0.320719391004763 1578 2377234
SGTC_2192 5915882 198.485 µM 0.464101468957528 0.33302900085872 no 1142 0.321287524682765 1523 2876149
SGTC_3314 9135860 59.4275 µM 0.462242101429827 0.333654631708586 no 1143 0.321953857300806 1556 25252478
SGTC_1776 st049249 45.9 µM 0.462130715133728 0.333692125132701 no 1144 0.321993792480541 1492 1822314
SGTC_1583 clindamycin 39.6 µM 0.461665040748831 0.333848892444475 no 1145 0.322160772352824 1461 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.46089563478677 0.334107973247638 no 1146 0.322436741869181 1508 260807
SGTC_2243 6634756 200 µM 0.458791066133209 0.334817044827796 no 1147 0.323192105435195 1636 885676
SGTC_2249 haloperidol 116.36 µM 0.458280093866208 0.334989290689838 no 1148 0.32337561179695 1590 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2661 dactinomycin 12.96 µM 0.457150369387078 0.335370237598921 no 1149 0.323781484213929 1540 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1985 st071382 65.5 µM 0.456594764702164 0.335557651519751 no 1150 0.323981171431133 1536 6123237
SGTC_3116 9124943 49.47 µM 0.455163822695155 0.336040518357641 no 1151 0.324495692593601 1459 41905195 YPL160W CDC60
SGTC_3338 9144300 39.5675 µM 0.454461519144011 0.336277607549061 no 1152 0.324748341268593 1586 4901274
SGTC_146 3448-8650 53.125 µM 0.45382585418557 0.336492256514387 no 1153 0.324977086724482 1575 2891488 YIL048W NEO1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.453719654027292 0.336528122984223 no 1154 0.325015309524987 1510 390807
SGTC_1554 st069299 38.7 µM 0.452808706922757 0.336835833844966 no 1155 0.325343246704173 1555 24207999
SGTC_1344 1488-0097 29.1 µM 0.452387270686141 0.336978228709549 no 1156 0.325495007789905 1557 747966
SGTC_1588 farnesol 29.9 µM 0.448561232498005 0.338272037176233 no 1157 0.326874102541945 1528 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1341 1486-1360 280 µM 0.446183795388597 0.339076952701129 no 1158 0.327732243640906 1530 3976547
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.446132153627296 0.339094444932244 no 1159 0.327750893967736 1680 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2357 9067248 200 µM 0.445155263204024 0.339425405090221 no 1160 0.328103777041735 1575 9150235
SGTC_3350 9150499 3.57 µM 0.444763157554795 0.339558281200912 no 1161 0.328245460928857 1530 4910996 YPR165W RHO1
SGTC_66 0109-0187 42.4 µM 0.444339858997802 0.339701750301393 no 1162 0.328398443833016 1501 759417
SGTC_2536 dehydroabietamide 32.04 µM 0.443942574218168 0.33983642365107 no 1163 0.328542051364651 1679 3983547
SGTC_3256 9138902 49.47 µM 0.443896266373756 0.339852122619491 no 1164 0.328558792026702 1613 17228773
SGTC_1995 st072814 61.1 µM 0.442081643389242 0.34046752213877 no 1165 0.329215063643034 1509 5769371
SGTC_2754 granisetron 64.02 µM 0.441451359314419 0.340681372143996 no 1166 0.329443133794338 1673 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3053 9095903 49.47 µM 0.440144830387647 0.341124829320893 no 1167 0.32991610719648 1623 17174018
SGTC_270 tamoxifen 5.46 µM 0.438888374521621 0.341551497988441 no 1168 0.330371210404317 1693 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_733 4069-0007 56.1 µM 0.43882173524114 0.341574133089775 no 1169 0.330395354956877 1608 5717425 YNL287W SEC21
SGTC_2971 9092186 9.93 µM 0.438040406779456 0.341839566326645 no 1170 0.330678496286571 1456 25236400
SGTC_983 1491-0821 12.2 µM 0.436758188087343 0.342275331635881 no 1171 0.331143362452198 1654 46495113
SGTC_2194 5927483 104.545 µM 0.43623029146225 0.342454799745429 no 1172 0.331334826169608 1589 760979
SGTC_426 0988-0037 14.6 µM 0.435986580711015 0.342537665677508 no 1173 0.331423232913677 1613 5383008
SGTC_357 1325-0123 420 µM 0.435071991547312 0.342848709607097 no 1174 0.33175508638566 1659 1098503
SGTC_712 r015-0009 80.6 µM 0.431057405127969 0.344215293936273 no 1175 0.333213315461801 1648 6813872 YLR060W FRS1
SGTC_736 0958-0254 92.6 µM 0.430354299051311 0.344454844689458 no 1176 0.333468967030171 1637 6812352
SGTC_2863 9028737 58.44 µM 0.428420440637171 0.345114038776519 no 1177 0.334172522729151 1683 6460917
SGTC_670 4204-0025 119 µM 0.428145286318415 0.345207868857648 no 1178 0.334272673870459 1652 719039
SGTC_2110 5483698 200 µM 0.427659082146461 0.345373692085554 no 1179 0.334449672141022 1599 2848765 YHR062C RPP1
SGTC_2720 fluspirilene 36.88 µM 0.426358677465724 0.345817349711443 no 1180 0.33492325358658 1637 3396 An atypical antipsychotic.
SGTC_3102 9121669 49.47 µM 0.426110990137755 0.345901876953492 no 1181 0.335013486167946 1618 41905072
SGTC_2776 terbinafine 19.92 µM 0.425030222017633 0.346270796096492 no 1182 0.335407321761203 1567 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1166 k206-0078 225 µM 0.424671007404129 0.346393445979544 no 1183 0.335538260878152 1550 5404595
SGTC_558 k064-0027 21.3 µM 0.424543578141161 0.346436959172669 no 1184 0.335584715557521 1664 5088526
SGTC_2875 9039966 71.43 µM 0.424398270051893 0.346486579910839 no 1185 0.335637691077797 1696 6463691
SGTC_2555 cholic acid 100 µM 0.423979696639258 0.346629531765966 no 1186 0.335790310228496 1621 6708657 Influences liver metabolism.
SGTC_1841 st054148 70 µM 0.422546445407166 0.347119183328679 no 1187 0.33631310360601 1539 675442
SGTC_1624 st003710 6.25 µM 0.422268701407839 0.347214100498831 no 1188 0.33641445029556 1685 24207033
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.421568745297784 0.34745334835953 no 1189 0.336669911710046 1576 442882
SGTC_2869 9037858 32.47 µM 0.421347583979759 0.347528954844043 no 1190 0.336750644140095 1530 27187042
SGTC_1730 st033808 45.1 µM 0.420420093187737 0.347846094035264 no 1191 0.337089296028258 1593 1045166
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.419445057005528 0.348179605348064 no 1192 0.337445450423247 1560 115019
SGTC_24 0417-1663 219 µM 0.417688680683478 0.348780670395158 no 1193 0.338087374673567 1583 4329390
SGTC_2928 9011484 9.79 µM 0.417378992542106 0.348886690930782 no 1194 0.338200609073585 1608 2994751
SGTC_1919 st067113 52.3 µM 0.416671555482928 0.349128923519328 no 1195 0.338459331318618 1578 1268243
SGTC_1433 4060-0023 7.6 µM 0.41645948485884 0.349201550323819 no 1196 0.338536904161311 1638 3840627
SGTC_2750 bromebric acid 70.15 µM 0.414172456100313 0.349985128483622 no 1197 0.339373906092287 1647 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_505 gw-5074 63.9 µM 0.413814615656846 0.350107789125962 no 1198 0.339504939634376 1680 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2295 7971645 200 µM 0.41296975195902 0.350397453763442 no 1199 0.339814387677153 1665 2978226 YKL099C UTP11
SGTC_521 r062-0005 13.8 µM 0.411949646720057 0.350747316579939 no 1200 0.340188165291095 1586 2832033
SGTC_1645 Cervolide 78 µM 0.408486891550441 0.351935871426065 no 1201 0.341458126176479 1600 23173 A fragrance.
SGTC_544 k015-0020 52.4 µM 0.407645473657078 0.352224898554646 no 1202 0.341766987033514 1630 3008304
SGTC_1085 doxorubicin 7.67 µM 0.404539696879466 0.353292471196613 no 1203 0.342907946323818 1731 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1487 3970-0795 2.82 µM 0.404514414324375 0.353301166516959 no 1204 0.342917240193727 1658 3765103
SGTC_832 4083-0019 164 µM 0.403573108256056 0.35362496032791 no 1205 0.343263332008565 1763 1990758
SGTC_2246 7293507 91.5585 µM 0.403488066013382 0.353654218682305 no 1206 0.343294606134394 1780 887656
SGTC_2051 5263410 176 µM 0.400506615380875 0.354680517076285 no 1207 0.344391705982964 1660 227584
SGTC_599 1935-0052 86.5 µM 0.400357451556803 0.354731891212702 no 1208 0.344446629067949 1599 9557311
SGTC_2316 5844804 197.44 µM 0.399804056124879 0.354922511525455 no 1209 0.344650421495543 1760 776813
SGTC_2493 resveratrol 26.09 µM 0.397742067661377 0.355633095062722 no 1210 0.345410162362125 1599 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_354 2783-3500 4.88 µM 0.397086233650235 0.355859207905268 no 1211 0.345651935580651 1562 6740761
SGTC_53 0973-0023 39.979 µM 0.396445320953342 0.356080225305789 no 1212 0.345888268895749 1770 674768
SGTC_1943 st076331 65.2 µM 0.391961905005496 0.35762767080871 no 1213 0.347543180770291 1675 24208415
SGTC_3017 9080681 49.47 µM 0.391506836992348 0.357784868388585 no 1214 0.347711317991346 1615 16451914
SGTC_3121 9125696 49.47 µM 0.391480572820912 0.357793941756192 no 1215 0.347721022916591 1696 1235365
SGTC_123 0083-0120 66.675 µM 0.389202989768606 0.358581073441022 no 1216 0.348562995982399 1576 16001701
SGTC_2198 6589944 200 µM 0.388996229006453 0.358652559680051 no 1217 0.348639467977658 1686 5290268
SGTC_753 1322-0200 289 µM 0.388104379353354 0.358960967837462 no 1218 0.348969395610916 1661 5403907
SGTC_1670 st016595 4.04 µM 0.387479959559973 0.359176951528764 no 1219 0.349200459201748 1655 597879
SGTC_2077 5212015 200 µM 0.387441967183352 0.359190094355731 no 1220 0.349214519906252 1564 780900
SGTC_2922 7999257 32.47 µM 0.386672275863387 0.359456392053305 no 1221 0.349499421657809 1604 2988377
SGTC_803 4488-1585 147 µM 0.386029827663608 0.359678718475908 no 1222 0.349737289224226 1724 747204
SGTC_2426 5582046 32.21 µM 0.385214595156167 0.359960907220036 no 1223 0.350039215405918 1671 2251934
SGTC_407 eburnamonine 100 µM 0.384527868969577 0.360198673376183 no 1224 0.350293622105583 1608 3195
SGTC_2327 6189656 200 µM 0.381719950951885 0.361171424534078 no 1225 0.351334549989094 1776 5349088
SGTC_1399 3562-5772 25 µM 0.381629474597508 0.361202783363997 no 1226 0.35136810922832 1634 23847490
SGTC_2507 purpurin 79.67 µM 0.381153936912744 0.361367618612672 no 1227 0.351544513396759 1563 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1940 st075990 51.1 µM 0.38093373987925 0.361443954055049 no 1228 0.351626207924035 1728 1084979
SGTC_2809 7964133 12.99 µM 0.380328031913079 0.361653962558352 no 1229 0.35185096484883 1682 1253665
SGTC_2511 berberine 10.47 µM 0.379961716568376 0.361780990093905 no 1230 0.351986916723351 1643 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1200 1643-0193 18.4 µM 0.379067129503665 0.362091270930713 no 1231 0.352319007405692 1703 5403974
SGTC_1947 st076332 61.6 µM 0.378708218896677 0.362215781883775 no 1232 0.352452274704824 1739 24208416
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.377336720261381 0.362691707547469 no 1233 0.352961693379084 1667 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1314 1222-0010 41.1 µM 0.376167193437121 0.363097714364527 no 1234 0.353396301573048 1680 3526027
SGTC_58 0957-0393 9 µM 0.375765185095009 0.363237309043477 no 1235 0.353545736199091 1641 6997992
SGTC_566 0958-0068 16.5 µM 0.375593354133936 0.363296981726329 no 1236 0.353609616128484 1701 6815365
SGTC_254 nsc-64875 3.808 µM 0.374760185110525 0.363586367937462 no 1237 0.353919413724621 1785 56993
SGTC_637 1181-0519 7.26 µM 0.373646339482679 0.363973363683755 no 1238 0.354333726513737 1649 6252091 YGR060W ERG25
SGTC_3277 9138724 49.47 µM 0.373523993272422 0.364015880251003 no 1239 0.354379245674037 1675 15943418
SGTC_209 4077-0173 175.592 µM 0.373271562848471 0.364103607710683 no 1240 0.354473169507942 1679 15993494
SGTC_9 0092-0002 10.449 µM 0.371649752427965 0.364667407188583 no 1241 0.355076820527896 1665 759368
SGTC_1182 1222-0449 220 µM 0.370170777503148 0.365181807255108 no 1242 0.355627624338031 1682 658318
SGTC_934 2950-0684 338 µM 0.369014389922291 0.365584177804197 no 1243 0.356058499478272 1788 1121253
SGTC_1847 st056231 15 µM 0.36739398931031 0.366148252730724 no 1244 0.356662577218476 1630 5393180
SGTC_1086 cerivastatin 2.18 µM 0.366613341576289 0.366420106065681 no 1245 0.35695372751097 1719 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_467 ro 31-8220 72.8 µM 0.365844832881769 0.366687797582859 no 1246 0.35724043183357 1781 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2558 carylophyllene oxide 100 µM 0.365257132993204 0.366892552471437 no 1247 0.357459736978923 1713 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2358 9037157 4 µM 0.365186967730109 0.366917000610575 no 1248 0.357485922883021 1705 2388925
SGTC_3039 9090270 49.47 µM 0.363738745896592 0.367421734380797 no 1249 0.358026553660973 1810 17173750
SGTC_1926 methyl fluorone black 53.6 µM 0.363315026836181 0.367569452166731 no 1250 0.358184784694735 1645 72721 Reacts with homocysteine.
SGTC_2529 gangaleoidin 93.61 µM 0.362831960373072 0.36773788366671 no 1251 0.358365207772765 1674 4565183
SGTC_1789 tunicamycin 25 nM 0.361398445325845 0.368237859129585 no 1252 0.358900805014768 1772 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_334 1502-1024 68.5 µM 0.361220844768714 0.368299817477576 no 1253 0.358967180388052 1704 3296216
SGTC_1126 isoteolin 1.0172 µM 0.359991124350094 0.368728915903892 no 1254 0.35942688548694 1607 133323
SGTC_758 0868-0029 16 µM 0.359577392280608 0.368873320331438 no 1255 0.359581596306403 1813 762687
SGTC_2800 7887935 81.82 µM 0.358314538642672 0.369314207100429 no 1256 0.360053969594216 1736 2961002
SGTC_2677 mitomycin C 100 µM 0.357706528433653 0.369526536647022 no 1257 0.360281473488342 1696 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1807 st050092 58.9 µM 0.357583837083442 0.369569387792797 no 1258 0.360327387864848 1677 5008496
SGTC_571 k831-0106 44.2 µM 0.356806418013923 0.369840946590101 no 1259 0.360618365617604 1795 4783639
SGTC_3038 9091290 49.47 µM 0.35555013080066 0.370279915090366 no 1260 0.361088747989732 1764 25236843
SGTC_2128 5255449 168.493 µM 0.353416330941352 0.371025888731386 no 1261 0.361888172223896 1668 736008
SGTC_1054 3429-0080 167 µM 0.352175142563617 0.371460029828623 no 1262 0.362353458825593 1762 1162877
SGTC_2906 7926292 26.41 µM 0.351211490004221 0.371797207674786 no 1263 0.36271484537253 1666 2966319
SGTC_1545 lovastatin 49.4 µM 0.349340124243981 0.372452271201829 no 1264 0.363416989410023 1723 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_130 0136-0219 337.655 µM 0.34657548246143 0.373420697252947 no 1265 0.364455133866114 1842 234244
SGTC_3255 9139072 49.47 µM 0.346071629725013 0.373597278134481 no 1266 0.364644441898709 1713 17646060
SGTC_976 1348-1067 47.6 µM 0.344250302940991 0.3742358037985 no 1267 0.36532902758339 1702 5310671 YGL099W LSG1
SGTC_2560 caryophyllene 100 µM 0.344118308625567 0.374282092156089 no 1268 0.365378657256581 1695 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2384 9036245 200 µM 0.343884507568365 0.374364087005507 no 1269 0.365466571651082 1793 6462766
SGTC_1784 st039334 36.3 µM 0.34180001410913 0.375095376946701 no 1270 0.366250699483512 1816 3496984
SGTC_3316 9136639 10.545 µM 0.340743645762508 0.375466147799562 no 1271 0.366648289120804 1772 4903665
SGTC_1142 3253-1408 9.78 µM 0.340566934737308 0.375528182196871 no 1272 0.366714812551351 1824 256655
SGTC_1436 4092-1007 8.32 µM 0.340309483448578 0.375618566219554 no 1273 0.36681173807726 1718 2881121
SGTC_1067 clotrimazole 1.36 µM 0.338800237867645 0.376148557734774 no 1274 0.36738011103604 1713 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3335 9143315 29.6265 µM 0.336530507004521 0.376946043352636 no 1275 0.368235425217976 1704 4899691
SGTC_2125 5246583 200 µM 0.336067005213522 0.37710896260263 no 1276 0.368410169433871 1883 835267
SGTC_928 2764-0428 58.7 µM 0.335721808874533 0.377230312118987 no 1277 0.368540329151009 1772 662578
SGTC_1043 0916-0009 19.3 µM 0.334500398909725 0.377659781002647 no 1278 0.369000994965098 1900 3101130
SGTC_1317 1273-0028 910 nM 0.333235084858479 0.378104846871889 no 1279 0.369478418115399 1712 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2589 lobaric acid 100 µM 0.333231600843156 0.378106072574944 no 1280 0.369479732968164 1665 73157 A novel microtubule depolymerizer.
SGTC_8 0354-0001 70 µM 0.333052452633191 0.378169099929205 no 1281 0.369547344807951 1739 4993152
SGTC_483 fpl-64176 144 µM 0.330833349870474 0.378950085945662 no 1282 0.370385184238339 1755 3423
SGTC_446 go6976 132 µM 0.330132468527524 0.379196855441474 no 1283 0.370649935454045 1855 3501 A protein kinase C inhibitor.
SGTC_969 1313-0238 134 µM 0.329669137515524 0.379360014172783 no 1284 0.37082498795183 1722 5212874
SGTC_29 0299-0004 12.984 µM 0.327066567944988 0.380276889185379 no 1285 0.37180876866916 1753 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2071 5230951 39.92 µM 0.32648251086594 0.380482742856713 no 1286 0.372029659669881 1808 1799272
SGTC_3066 9117245 49.47 µM 0.326433158904608 0.380500138739902 no 1287 0.372048326564545 1824 17176980
SGTC_190 3970-0790 3.722 µM 0.325418026093047 0.38085801256204 no 1288 0.372432357232645 1821 2832352
SGTC_1845 st056753 3.01 µM 0.325131557865467 0.380959022218586 no 1289 0.372540752805797 1671 5375839
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.324795845044754 0.381077406007741 no 1290 0.37266779469308 1789 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1335 1486-0900 202 µM 0.323196088389553 0.381641687486532 no 1291 0.373273371548803 1731 X1335
SGTC_358 0075-0058 9.45 µM 0.3214654472498 0.382252419127181 no 1292 0.373928846449972 1976 1069125
SGTC_186 3455-3465 67.277 µM 0.321286763921255 0.382315491990508 no 1293 0.3739965430048 1744 755278
SGTC_264 promethazine 12.5 mM 0.320243891139955 0.382683674603712 no 1294 0.374391726697734 1845 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2738 aclarubicin 5.55 µM 0.316682157452599 0.383941930064082 no 1295 0.375742394394061 1819 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_389 tpck 16.7 µM 0.315742302571671 0.384274157792466 no 1296 0.3760990575615 1761 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1042 0350-0096 82 µM 0.315433570225404 0.384383309639662 no 1297 0.376216240735308 1699 3122515
SGTC_1220 1838-0075 193 µM 0.31198924404106 0.385601665708019 no 1298 0.377524348829754 1789 5529645
SGTC_511 blebbistatin 171 µM 0.310530047628662 0.386118166319699 no 1299 0.37807895666666 1847 3476986 A myosin inhibitor.
SGTC_1637 st007924 17.4 µM 0.310321227860642 0.386192097193797 no 1300 0.378158344962737 1736 683336
SGTC_756 0508-1999 28.3 µM 0.307727999417247 0.387110551326031 no 1301 0.379144656227501 1666 6753853
SGTC_477 mead ethanolamide 10 µM 0.305546045028032 0.387883833037043 no 1302 0.379975153311867 1771 16061185
SGTC_1971 st069429 63.5 µM 0.302718900396188 0.388886430515428 no 1303 0.381052046397149 1898 1246522 YGL099W LSG1
SGTC_227 fluconazole 33.516 µM 0.300872193484746 0.389541733121495 no 1304 0.381755977401098 1745 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2859 9028643 45.46 µM 0.300318370793619 0.389738318026948 no 1305 0.381967160870047 1871 17151580
SGTC_1107 amlodipine 47 µM 0.299530118758179 0.390018164614878 no 1306 0.382267797416289 1750 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2292 7671323 168.05 µM 0.299118699350579 0.390164250091216 no 1307 0.382424739533955 1767 937504
SGTC_230 MPP+ 141.667 µM 0.298303787074676 0.390453652287455 no 1308 0.382735657066609 1724 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2512 diallyl trisulfide 49.23 µM 0.298164466566748 0.39050313567048 no 1309 0.382788820284283 1826 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2652 actinonin 100 µM 0.297252570264662 0.390827063652282 no 1310 0.383136844664009 1819 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1629 st005085 44.9 µM 0.296681109152605 0.391030099320396 no 1311 0.383354990374874 1702 24207091
SGTC_1262 0737-0114 49.6 µM 0.296287840701923 0.391169841786349 no 1312 0.38350513551067 1926 765919
SGTC_2274 7947094 46.08 µM 0.294950348689961 0.39164520599253 no 1313 0.384015904585949 1749 2971028
SGTC_449 xestospongin c 11.1929 µM 0.293376133115039 0.392204912510372 no 1314 0.384617333138268 1864 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1430 4049-0248 69.1 µM 0.292555954198954 0.392496612557987 no 1315 0.38493079239737 1911 22774488
SGTC_2335 9018011 154.17 µM 0.290526649153284 0.393218602650649 no 1316 0.38570668321852 1904 6458208
SGTC_176 1486-1328 72.834 µM 0.289650476983196 0.393530442597633 no 1317 0.386041823221247 1744 22310231
SGTC_2183 6420625 130.508 µM 0.289617548894807 0.393542163423292 no 1318 0.386054420030903 1780 2897619
SGTC_88 0180-0332 8.668 µM 0.28954363389952 0.393568473980122 no 1319 0.386082697030178 1805 3101745
SGTC_697 0508-1955 564 µM 0.288844489858601 0.393817363187247 no 1320 0.3863501922332 1924 6243113
SGTC_2179 6298986 200 µM 0.288369300993463 0.393986551065375 no 1321 0.386532032168539 1931 738374
SGTC_1438 4092-1045 4 µM 0.288103432414048 0.394081220560674 no 1322 0.386633782642957 1793 1351342
SGTC_2528 xanthyletin 44.79 µM 0.28783636247101 0.394176324134184 no 1323 0.386736000737885 1772 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1785 bathophenanthroline 24 µM 0.286477943733901 0.394660154434281 no 1324 0.387256042120279 1746 72812 An iron chelator.
SGTC_2181 6316240 54.2555 µM 0.285354557053796 0.395060395786196 no 1325 0.387686259489445 1734 12779990
SGTC_1757 st041620 31.8375 µM 0.284430788129244 0.395389600122491 no 1326 0.388040133686842 1764 5289815
SGTC_1265 0819-1001 68.8 µM 0.284413543953368 0.395395746155101 no 1327 0.388046740410976 1804 3106768
SGTC_1998 st075797 76.8 µM 0.284093525503791 0.395509809316882 no 1328 0.388169354271987 1917 24208315
SGTC_2328 6201408 200 µM 0.283406512014814 0.395754709580829 no 1329 0.388432618537303 1772 2890418
SGTC_205 1486-1330 71.903 µM 0.282997349830903 0.395900583524687 no 1330 0.388589434265249 1836 4118834
SGTC_3091 9116372 49.47 µM 0.282862081688032 0.395948812346454 no 1331 0.388641281204703 1833 17169793
SGTC_1678 st019265 80.2 µM 0.281731051161747 0.396352134903961 no 1332 0.38907487156076 1967 5367020
SGTC_1286 0929-0070 131 µM 0.28170683299154 0.396360772255547 no 1333 0.389084157319164 1879 1420408
SGTC_508 roscovitine 141 µM 0.281462572922417 0.396447889859001 no 1334 0.389177815333876 1849 160355 A CDKinase inhibitor.
SGTC_2805 7950783 58.44 µM 0.280156418967989 0.396913829339786 no 1335 0.389678750458087 1831 1178958 YDL195W SEC31
SGTC_3171 9103192 49.47 µM 0.277523697238666 0.397853437186558 no 1336 0.390689006191892 1952 13018434
SGTC_762 1165-0429 115 µM 0.276006673941248 0.398395126297751 no 1337 0.391271470104585 1933 5967793
SGTC_2771 fluoxetine 41.05 µM 0.274717548336831 0.398855593106192 no 1338 0.391766624041639 1902 3386 A selective serotonin reuptake inhibitor.
SGTC_2656 pseudo-anisatin 100 µM 0.27353180624889 0.399279256376466 no 1339 0.392222223177735 1848 6708809 A neurotoxin.
SGTC_15 0266-0086 27.098 µM 0.273523088333486 0.399282371710156 no 1340 0.392225573421084 1941 1712902 YIL048W NEO1
SGTC_1948 st076329 66.6 µM 0.273344400373902 0.399346226991049 no 1341 0.392294243907182 1892 24208413
SGTC_598 3937-0236 20.2 µM 0.272180509382816 0.399762216676169 no 1342 0.39274161378061 1881 1379313
SGTC_2999 9069765 71.4286 µM 0.271120317672768 0.400141241953827 no 1343 0.39314924768528 1880 2097066
SGTC_2188 6126565 140.678 µM 0.270641936604239 0.400312297052561 no 1344 0.393333219174336 1912 874518
SGTC_404 fumagillin 50 µM 0.269467978262127 0.400732151256718 no 1345 0.393784790389053 1851 12015870 A methionine aminopeptidase binder.
SGTC_1502 4534-4282 27.7 µM 0.268747350966038 0.400989933091892 no 1346 0.394062055480231 1835 3278949
SGTC_635 k038-0028 24.7 µM 0.268071764252549 0.401231642228898 no 1347 0.394322039748452 1877 4035102
SGTC_658 3253-0951 102 µM 0.263478724650108 0.4028759221195 no 1348 0.396090809832452 1863 1184878
SGTC_682 0kpi-0099 17 µM 0.262968961030884 0.403058520876895 no 1349 0.396287251432734 1799 1714895 YML126C ERG13
SGTC_2595 hexamethylquercetagetin 100 µM 0.262832373006711 0.403107450683102 no 1350 0.396339891225923 1849 386331
SGTC_23 0213-0011 39.996 µM 0.26203927119764 0.403391592795446 no 1351 0.396645582828837 1951 627608
SGTC_1353 1498-1206 8.11 µM 0.261377078615564 0.403628873547742 no 1352 0.396900865715179 1839 6756808
SGTC_3281 9140613 49.47 µM 0.261235366358008 0.403679657331037 no 1353 0.396955503170452 1751 16013766
SGTC_2092 5303694 80.6725 µM 0.25996838264323 0.404133763700651 no 1354 0.397444081137043 1806 1963699
SGTC_375 3970-0961 9.27 µM 0.259160134692254 0.404423519691232 no 1355 0.397755844210905 1866 2898222
SGTC_312 4092-0653 6.84 µM 0.257122116086202 0.405154379539773 no 1356 0.398542252593524 1927 1148278
SGTC_1446 4239-0190 62 µM 0.256665326838972 0.405318235560291 no 1357 0.398718570100266 1822 1340085
SGTC_2481 5478948 45.16 µM 0.255692233299003 0.40566735169527 no 1358 0.399094246396924 1838 77792
SGTC_606 k015-0008 38.6 µM 0.254496451821171 0.406096464187561 no 1359 0.39955602245753 1963 1970475
SGTC_3130 9127414 49.47 µM 0.253076405999193 0.406606201646107 no 1360 0.4001045854025 1935 1494646
SGTC_2369 9071472 200 µM 0.253072068085083 0.40660775902001 no 1361 0.400106261439025 1886 17296037
SGTC_1144 3486-0183 12.5 µM 0.252591156409374 0.406780422420856 no 1362 0.400292082314118 1874 6744069
SGTC_1925 st057770 10.1 µM 0.251877391255135 0.40703672142009 no 1363 0.400567917731791 1722 5989122
SGTC_2045 5106652 78.05 µM 0.250135239607425 0.407662460717277 no 1364 0.401241382356914 1949 673349
SGTC_930 2810-3379 265 µM 0.249503883772243 0.407889286924325 no 1365 0.401485518533592 1996 1015764
SGTC_1689 st020265 53.493 µM 0.249023135737912 0.408062025217324 no 1366 0.401671442648262 1986 5758320 YPR016C TIF6
SGTC_3163 9099914 49.47 µM 0.246507055894705 0.408966372386375 no 1367 0.402644871560579 1971 16268368
SGTC_2461 5755302 26.15 µM 0.244801489877052 0.409579674972986 no 1368 0.403305070129518 1982 2788904
SGTC_1974 st069448 26.9 µM 0.243337245794001 0.410106377512623 no 1369 0.403872076681193 1988 6323587 YNR016C ACC1
SGTC_2234 tolnaftate 200 µM 0.243316738906698 0.410113755189291 no 1370 0.403880019103061 1970 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_836 0330-0104 1.35 µM 0.243185375760113 0.410161015911091 no 1371 0.403930897658495 1896 46494820
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.242452209869782 0.410424812080822 no 1372 0.404214891614393 1904 7104
SGTC_2228 7354201 200 µM 0.242010748393513 0.410583671334146 no 1373 0.404385917371956 1957 753451
SGTC_622 1348-1566 26.3 µM 0.241488352087198 0.410771673814639 no 1374 0.404588321542144 1942 7340407
SGTC_3189 9110682 49.47 µM 0.241064330508071 0.410924287803432 no 1375 0.404752628877706 1855 17122418
SGTC_2441 5730946 39.09 µM 0.240687683846979 0.411059861905288 no 1376 0.404898592633849 1948 1774275
SGTC_3134 9127454 49.47 µM 0.239899136285508 0.411343734271177 no 1377 0.405204225226952 1972 24262820
SGTC_3220 9131269 49.47 µM 0.238461396527654 0.411861431294484 no 1378 0.405761626462967 1916 17722206
SGTC_1564 D-Arginine 115 µM 0.237878686983885 0.412071295350807 no 1379 0.40598759320326 1788 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1835 st008666 49.2 µM 0.234633617006552 0.413240472451235 no 1380 0.407246557608514 1843 690455
SGTC_148 3253-0744 288.01 µM 0.234272769463022 0.413370531168906 no 1381 0.407386612280953 1960 6893655
SGTC_2049 5262831 67.185 µM 0.234225976097245 0.413387397395722 no 1382 0.407404774916981 1883 763417
SGTC_1851 st056236 18.9 µM 0.233973585854118 0.413478371830655 no 1383 0.407502742494676 2003 5393171
SGTC_1350 1495-0454 146 µM 0.233601379207343 0.413612542739588 no 1384 0.407647228458977 1971 1069057
SGTC_718 1130-0073 349 µM 0.230593297888233 0.414697247434312 no 1385 0.408815387409359 1952 6740020
SGTC_2107 5363541 170.161 µM 0.23042746860977 0.414757063953832 no 1386 0.408879809253057 1964 244052
SGTC_447 ml7 120 µM 0.229877522934733 0.414955449794992 no 1387 0.409093471369023 2014 4216 Selective myosin light chain kinase inhibitor.
SGTC_3289 9119912 71.43 µM 0.229415523194627 0.415122127035229 no 1388 0.409272986055633 1913 17014829
SGTC_877 0771-0151 33.1 µM 0.226597930234226 0.416138969410145 no 1389 0.410368200933829 1928 6166523
SGTC_1660 st012960 28.1 µM 0.225876901417112 0.416399272336901 no 1390 0.410648581786434 1905 24207266
SGTC_3010 9080089 71.4286 µM 0.225744616939121 0.416447033131895 no 1391 0.41070002718157 1991 17027233
SGTC_2603 homopterocarpin 100 µM 0.225448095765914 0.416554095426012 no 1392 0.410815349760029 1884 101795 A weak amylase inhibitor.
SGTC_2930 9013230 14.89 µM 0.223476027308573 0.417266289978289 no 1393 0.411582519402562 1989 2995857
SGTC_961 1252-1571 372 µM 0.219650928637426 0.418648461645672 no 1394 0.413071512269254 2026 6813498
SGTC_2021 4019055 173 µM 0.219368892940795 0.418750413186834 no 1395 0.413181349858121 1946 44827708 YER133W GLC7
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.217728320158654 0.419343562856275 no 1396 0.413820398344828 1960 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_252 miconazole 1.30953 nM 0.217687348978866 0.419358378352859 no 1397 0.413836360681729 1987 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3246 9135460 32.98 µM 0.217640980597768 0.419375145657237 no 1398 0.413854425935415 1979 41446951
SGTC_485 niflumic acid 177 µM 0.217456299906498 0.419441929630306 no 1399 0.41392637986884 1987 4488 A COX2 inhibitor.
SGTC_2370 9071495 200 µM 0.217172172440829 0.419544679937606 no 1400 0.414037085165464 1871 21791103
SGTC_702 1488-0190 94 µM 0.212761247259867 0.42114052230248 no 1401 0.415756595927117 2064 949357
SGTC_797 k781-0471 270 µM 0.211471441009971 0.421607411475666 no 1402 0.416259707530534 1976 23738129
SGTC_2626 ethyl orsellinate 100 µM 0.211056518640221 0.421757630182649 no 1403 0.416421584511053 1911 75653 A natural product.
SGTC_2265 7929201 200 µM 0.210558561941193 0.421937925710864 no 1404 0.416615875051694 1877 1265108
SGTC_376 3970-0862 59.1 µM 0.209858261530621 0.422191511645749 no 1405 0.416889149626982 2035 3135186
SGTC_2269 7935389 174.42 µM 0.208846444473384 0.422557957891632 no 1406 0.417284056622258 1854 97605
SGTC_787 4152-0075 138 µM 0.20869767275664 0.422611843684328 no 1407 0.41734212850544 1920 9566539
SGTC_1753 st043925 64 µM 0.205807496361535 0.423658964881454 no 1408 0.418470642652574 2054 670181
SGTC_2915 7971052 15.16 µM 0.204772090062893 0.42403422787077 no 1409 0.418875096916587 2035 5741558
SGTC_580 1123-0028 41 µM 0.202311128667365 0.424926431589591 no 1410 0.419836750221014 2028 1677248 YPR107C YTH1
SGTC_2447 5741742 33.78 µM 0.200520259126763 0.425575940470883 no 1411 0.420536857623547 1987 1776504
SGTC_1358 1509-0022 2.48 µM 0.19887536322294 0.42617268596341 no 1412 0.421180120926317 1972 3258434
SGTC_2463 5473429 200 µM 0.195850830746707 0.427270384859971 no 1413 0.422363461615115 1946 5399405
SGTC_2989 9073649 71.4286 µM 0.195147212261253 0.427525831438043 no 1414 0.422638851483927 2101 21367202
SGTC_935 2996-0153 430 µM 0.194985029149062 0.427584715842816 no 1415 0.422702333845009 2086 23738523
SGTC_2673 kobusone 100 µM 0.19434992619176 0.427815320468253 no 1416 0.422950947687779 2007 6710676 An epoxy ketone and protein crosslinker.
SGTC_1205 4161-2785 76 µM 0.194270049269558 0.427844325367784 no 1417 0.422982218034469 1857 3498106
SGTC_1526 st051518 75 µM 0.193823487189603 0.428006488121993 no 1418 0.423157047814003 1913 673993
SGTC_1761 st044296 37 µM 0.192807357534148 0.428375526623134 no 1419 0.423554920564882 1967 1826700
SGTC_2326 6164455 177.58 µM 0.192622964312858 0.428442501374617 no 1420 0.42362712940288 1935 2888790
SGTC_2793 7325131 81.82 µM 0.192021378431337 0.428661021910821 no 1421 0.42386272973174 1972 4176441
SGTC_2556 citropten 84.59 µM 0.190869076776669 0.42907964589896 no 1422 0.424314083949244 1921 2775 A potential DNA crosslinker.
SGTC_433 pimozide 108 µM 0.190798190339136 0.429105401108379 no 1423 0.424341853270348 1811 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1458 k015-0034 6.33 µM 0.188287355980546 0.430017857867135 no 1424 0.425325698278686 1887 3598957
SGTC_668 1682-0499 62.6 µM 0.188227383052873 0.430039657087283 no 1425 0.425349203775553 1948 682214
SGTC_1965 Pectolinarigenin 58.4 µM 0.187065727465849 0.43046194269656 no 1426 0.425804549650306 1956 5320438 An anti-inflammatory.
SGTC_2772 vinpocetine 57.06 µM 0.186665951721661 0.430607287791706 no 1427 0.425961276705387 2045 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3336 9143619 71.43 µM 0.186657634280704 0.430610311835062 no 1428 0.425964537577844 2073 45595730
SGTC_2105 5350118 200 µM 0.186488933685462 0.430671648635597 no 1429 0.426030678138773 1943 2133313
SGTC_2572 astragaloside iv 100 µM 0.186441104041277 0.430689039022928 no 1430 0.426049430552638 1952 45006101 An anti-inflammatory agent.
SGTC_782 0083-0095 30.5 µM 0.184258776153264 0.431482654390943 no 1431 0.426905226013171 2104 3591729 An indicator and reagent.
SGTC_2197 6588183 93.1375 µM 0.183815459072859 0.431643902963299 no 1432 0.42707911409766 2000 884136
SGTC_3003 9075612 71.4286 µM 0.18232181005732 0.432187274476726 no 1433 0.427665091791192 1987 6501993
SGTC_274 sirtinol 40.1 µM 0.182098044751968 0.432268688673277 no 1434 0.42775289157116 1899 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_793 0488-0545 106 µM 0.181730227781281 0.432402520507246 no 1435 0.427897221310306 1915 292548
SGTC_2066 5222451 176 µM 0.178970143413134 0.433407035859691 no 1436 0.428980572632252 2059 2281147
SGTC_2787 5284540 71.43 µM 0.178472739411135 0.433588108872309 no 1437 0.429175864140656 1974 736958
SGTC_1114 scopoletin 1.73284 µM 0.17780331694012 0.433831824815491 no 1438 0.429438721158848 2104 5280460 A coumarin with genotoxic properties.
SGTC_1351 1496-0003 46.5 µM 0.176016666949571 0.434482411548848 no 1439 0.430140424270736 2089 3891978
SGTC_2277 7947813 106.88 µM 0.175634555548292 0.434621575836654 no 1440 0.430290526461004 2076 1246798
SGTC_1002 4049-0206 172 µM 0.174984847916212 0.434858216780531 no 1441 0.43054576975104 1967 4662749
SGTC_2400 5203494 178.7 µM 0.174325322340465 0.435098457551153 no 1442 0.430804899786148 2054 6777674
SGTC_751 0833-0568 350 µM 0.173779795505712 0.435297190907401 no 1443 0.431019261814115 1995 6954252
SGTC_1027 k015-0025 8.67 µM 0.173591278225714 0.435365870839691 no 1444 0.431093343459889 1978 3598955
SGTC_2886 9058944 51.95 µM 0.171940801382975 0.435967249616981 no 1445 0.431742034679761 2078 4949929
SGTC_323 4013-0906 34.3 µM 0.16818893340575 0.437334854076667 no 1446 0.433217323396641 2118 2910086
SGTC_2834 9001755 58.44 µM 0.167734764951071 0.437500455510174 no 1447 0.433395972585099 1968 2989575
SGTC_2737 bleomycin 30.5 nM 0.167206835956708 0.4376929656816 no 1448 0.433603652913603 2069 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3085 9117376 49.47 µM 0.166432280077448 0.437975435431781 no 1449 0.433908386182598 2018 16480349
SGTC_2659 sanguinarine 24.21 µM 0.166244329607532 0.438043983123374 no 1450 0.433982337405046 2029 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2954 9074818 52.69 µM 0.165953632394128 0.438150007391101 no 1451 0.434096720037057 2031 16648742
SGTC_3061 glucosamine 200 µM 0.165815682611531 0.438200322549613 no 1452 0.434151002018094 2129 91431 and experimental redox chemotherapeutic
SGTC_2939 9044578 71.43 µM 0.165024124708895 0.438489050964905 no 1453 0.434462496804603 2022 2653634
SGTC_210 3551-0445 56.827 µM 0.16485484478363 0.438550801712814 no 1454 0.434529117325789 2074 2865180 YOR207C RET1
SGTC_2990 9074105 71.4286 µM 0.163873859002361 0.438908679845971 no 1455 0.43491522318288 2091 6502001
SGTC_2837 9008476 45.46 µM 0.163839875239488 0.4389210785225 no 1456 0.434928599954991 2035 2992805
SGTC_2275 7947463 200 µM 0.163534260371318 0.439032582106578 no 1457 0.43504890017399 2127 1225414
SGTC_2977 9011197 71.43 µM 0.16247346485922 0.439419650833771 no 1458 0.435466511300555 2094 2704722
SGTC_3047 9092122 49.47 µM 0.162245952754881 0.439502674221032 no 1459 0.435556087044643 1992 17173831
SGTC_2956 9076196 2.52 µM 0.162153347241257 0.439536468452988 no 1460 0.435592548503664 2140 16423868
SGTC_2966 9084041 48.03 µM 0.162044933687344 0.439576032022039 no 1461 0.435635234739305 1822 17741380
SGTC_1288 0973-0013 65.5 µM 0.161197778271137 0.439885206847884 no 1462 0.435968815459071 2038 4315430
SGTC_982 1491-0518 27.5 µM 0.160281692722814 0.440219579424255 no 1463 0.436329589759098 2009 3091256
SGTC_3036 9090181 49.47 µM 0.156200930895799 0.441709578233588 no 1464 0.437937321497074 2054 25236586
SGTC_363 0455-0021 3.06 µM 0.155978626138869 0.441790771730574 no 1465 0.438024934434517 2057 4597466
SGTC_347 4534-1311 26.2 µM 0.155299654170857 0.442038771244482 no 1466 0.438292544119486 2102 2862016
SGTC_777 1315-0167 517 µM 0.155195839996562 0.442076692141444 no 1467 0.438333463878431 1966 4221767
SGTC_2001 4023502 57.655 µM 0.154959644851333 0.442162970697167 no 1468 0.438426565840725 2057 108941 YCR052W RSC6
SGTC_1449 4112-4002 201 µM 0.154812688249393 0.442216653131874 no 1469 0.438484494018091 1959 2059539
SGTC_1217 1183-1422 255 µM 0.154339423436271 0.442389541359577 no 1470 0.438671057146065 2097 2849664
SGTC_755 1995-0008 37.3 µM 0.154282809834711 0.442410223592924 no 1471 0.438693375397035 2125 689533
SGTC_3291 9121177 71.43 µM 0.154137277801935 0.442463390467191 no 1472 0.438750748024494 2007 17015612
SGTC_1617 st002906 78 µM 0.153091199371205 0.442845582270575 no 1473 0.439163177976699 2006 5150859
SGTC_2546 rhodinyl acetate 100 µM 0.150908697060866 0.443643145041415 no 1474 0.440023869899423 2161 6708682
SGTC_3069 9117009 49.47 µM 0.150612757924326 0.443751309216547 no 1475 0.44014059841725 2148 41904981
SGTC_680 0417-1641 114 µM 0.150376072851627 0.443837819363892 no 1476 0.440233958850657 2019 2835990
SGTC_3079 9117512 49.47 µM 0.150184135037174 0.44390797602228 no 1477 0.44030967116703 2153 7185044
SGTC_790 1575-0012 79.1 µM 0.150042656824215 0.443959689931381 no 1478 0.440365480448122 2156 378741 YLR208W SEC13
SGTC_1739 st037196 92.5 µM 0.149628130399636 0.444111215443273 no 1479 0.440529006588941 2149 612214
SGTC_136 0097-0015 404.482 µM 0.148500662702309 0.444523389954035 no 1480 0.440973831496684 2170 4861337
SGTC_2061 5245884 80.95 µM 0.147778578972227 0.444787397584686 no 1481 0.441258757603901 2068 573863
SGTC_2088 5278280 127.392 µM 0.147219533412499 0.444991812169172 no 1482 0.441479371575709 2061 791502
SGTC_678 1218-2179 85.9 µM 0.146610268973615 0.445214605905508 no 1483 0.441719823903639 2156 6820081 YOR116C RPO31
SGTC_1504 k297-0033 30 µM 0.14617920497331 0.445372246372167 no 1484 0.441889960618918 1975 4388117
SGTC_3005 9076496 71.4286 µM 0.146177419850926 0.445372899210898 no 1485 0.441890665211454 2166 21368410
SGTC_59 0330-0160 1.33 µM 0.145225469255238 0.445721058987643 no 1486 0.442266428770221 2083 4293482
SGTC_1609 st001574 46.4 µM 0.143299626491311 0.446425531029368 no 1487 0.443026775402552 2087 3960012
SGTC_419 nsc-638432 893 µM 0.14325157928954 0.446443108836359 no 1488 0.443045747729015 2046 368090
SGTC_3235 9132602 49.47 µM 0.14248356709516 0.446724096175769 no 1489 0.443349029248724 2090 4912240
SGTC_2113 5491891 107.031 µM 0.142258954931005 0.446806278545241 no 1490 0.443437732973091 2024 789979
SGTC_1778 st046819 58.9 µM 0.141995999413118 0.446902493100403 no 1491 0.443541582836853 2036 671715
SGTC_1511 0906-3109 28.5 µM 0.141815126334873 0.446968675776718 no 1492 0.443613017871562 2166 2882180
SGTC_2134 5324836 1.464 µM 0.141571872023546 0.447057686494426 no 1493 0.443709092991544 2083 699272
SGTC_1861 st057647 17.4 µM 0.141126541652939 0.447220647043303 no 1494 0.443884988140358 2142 688668
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.140347999925838 0.44750556161772 no 1495 0.444192520569264 2055 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2549 cedrol 20.94 µM 0.140248193066552 0.447542088826733 no 1496 0.444231947795534 2162 6708665 A sedative which affects the nervous system.
SGTC_2619 obliquin 87.91 µM 0.139862670755905 0.447683186050594 no 1497 0.444384247872402 2115 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1372 2752-0194 270 µM 0.139360372725096 0.4478670319235 no 1498 0.444582692359371 2127 823334
SGTC_2707 st078556 66.6 µM 0.139081565805671 0.447969082752729 no 1499 0.444692847497812 2183 17250899
SGTC_3295 9122362 53.5725 µM 0.137156870181674 0.448673666691135 no 1500 0.445453400629198 2010 4730473
SGTC_1949 st076024 69.1 µM 0.133981458219572 0.449836460152905 no 1501 0.446708618212884 2162 2921930
SGTC_2023 5144124 124 µM 0.133503369694096 0.450011567348136 no 1502 0.44689764974843 2068 2830192
SGTC_1806 st050005 60.3 µM 0.131588576738451 0.4507129866119 no 1503 0.447654860696471 2029 5194765
SGTC_1567 st069303 68.4 µM 0.130810043358303 0.450998219979712 no 1504 0.447962788909236 2064 5581319
SGTC_2840 9008771 71.43 µM 0.128915593410654 0.45169240011952 no 1505 0.448712218936728 2174 2992978
SGTC_2221 6807166 181.081 µM 0.128284833594811 0.451923561276317 no 1506 0.448961783485093 2162 674925
SGTC_38 0929-0051 58.268 µM 0.128092183643094 0.451994166975229 no 1507 0.449038010821118 2180 1379719
SGTC_1308 1187-1617 41.4 µM 0.127922689027888 0.452056287560068 no 1508 0.449105077656914 2099 2882570
SGTC_657 3534-0529 86.7 µM 0.127295040480781 0.452286333955411 no 1509 0.449353442749443 2176 1049549
SGTC_3049 9092223 49.47 µM 0.126781249719937 0.452474661004441 no 1510 0.449556768263708 2094 8623917
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.126616379525003 0.452535095494463 no 1511 0.449622016149093 2141 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_45 0kpi-0036 14.9 µM 0.126405514332087 0.452612391421657 no 1512 0.449705468680853 2105 2795021
SGTC_2212 7123476 200 µM 0.126381644654886 0.452621141337547 no 1513 0.449714915543727 2134 1085715
SGTC_253 dyclonine 31.25 µM 0.125525188703554 0.452935107884693 no 1514 0.450053892521495 2147 3180 An oral anasthetic.
SGTC_2470 5664817 21.68 µM 0.124595817258994 0.453275837667156 no 1515 0.450421769968496 2210 2859561
SGTC_2894 9048625 32.47 µM 0.122519253799545 0.454037279394738 no 1516 0.451243899267671 2191 4092861
SGTC_2009 4012297 12.05 µM 0.122474771597817 0.454053592146253 no 1517 0.451261512454192 2063 45595307
SGTC_583 1488-1091 88.9 µM 0.122327503796077 0.454107599537027 no 1518 0.4513198253436 2213 4303273
SGTC_2862 9027634 71.43 µM 0.120932412000019 0.454619262274097 no 1519 0.451872284750648 2096 5012562
SGTC_2154 5570129 200 µM 0.120021021545804 0.454953563820414 no 1520 0.452233247771604 2187 673366
SGTC_1283 0922-0125 16.4 µM 0.119655730879478 0.455087562820593 no 1521 0.452377934979566 2155 3360884
SGTC_1459 k035-0031 35.7 µM 0.119367807860251 0.455193184770741 no 1522 0.452491982257591 2078 3877128 YMR208W ERG12
SGTC_720 r052-1644 49.9 µM 0.119240688710292 0.455239818287193 no 1523 0.452542335829065 2129 1422863 YOR257W CDC31
SGTC_595 3909-8003 73.7 µM 0.118529258136957 0.455500817155959 no 1524 0.45282415692624 2142 699517
SGTC_48 0382-0018 55 µM 0.117843354852574 0.455752469146541 no 1525 0.453095888326367 2196 762596
SGTC_2014 4013930 200 µM 0.117546377728293 0.45586143300155 no 1526 0.453213547317575 2219 64556
SGTC_2342 7990637 118.86 µM 0.117025311279869 0.456052625472027 no 1527 0.453419997894073 2112 2033102 YER133W GLC7
SGTC_60 0986-0278 202 µM 0.116253067446511 0.456335999987894 no 1528 0.453725990041161 1924 3110598
SGTC_128 0906-2981 13.371 µM 0.11430001338743 0.457052771055061 no 1529 0.454499985944013 2208 6740226
SGTC_2281 7943571 200 µM 0.11329894248979 0.457420218507472 no 1530 0.454896777806998 2238 1244024
SGTC_2827 7993847 71.43 µM 0.112404405680688 0.457748592963381 no 1531 0.455251381119915 2126 2985692
SGTC_963 1269-2853 151 µM 0.111610807460409 0.458039938145114 no 1532 0.45556600122717 2102 3668223
SGTC_1570 verbenone 133 µM 0.110405754159779 0.458482379466453 no 1533 0.456043794934954 2231 29025 A natural terpanoid with antifungal properties.
SGTC_2160 5660466 132.927 µM 0.110325479596651 0.458511854505699 no 1534 0.456075625404078 2218 2859134
SGTC_1041 0206-0046 107 µM 0.110086270018484 0.45859968830966 no 1535 0.456170478454922 2106 50494
SGTC_1485 3909-9022 254 µM 0.108217757756132 0.459285844362256 no 1536 0.456911479513269 2193 714516
SGTC_1405 3909-7894 12 µM 0.108039844386024 0.459351184160165 no 1537 0.456982042962469 2214 7104060
SGTC_1479 0549-0158 134 µM 0.106363035465083 0.459967056423285 no 1538 0.457647160046225 2169 5440202
SGTC_967 1306-0166 352 µM 0.10622874706998 0.46001638315115 no 1539 0.457700431560522 2223 4437607
SGTC_3105 9121040 49.47 µM 0.104809225272811 0.460537838481745 no 1540 0.458263594830957 2221 41448907
SGTC_980 1473-0395 201 µM 0.104494743125281 0.460653371384187 no 1541 0.458388369910611 2152 768876
SGTC_492 tmb-8 126 µM 0.104385730202931 0.460693420790419 no 1542 0.458431623231486 2220 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.103399769311781 0.461055663324269 no 1543 0.458822847614376 2147 641818 YHR062C RPP1
SGTC_3267 9137951 49.47 µM 0.103371735109063 0.46106596357855 no 1544 0.458833972031688 2077 16643986
SGTC_987 1497-1013 404 µM 0.102233792006428 0.46148408566309 no 1545 0.45928555306163 2217 1676435
SGTC_3248 9135562 49.47 µM 0.101602463122959 0.461716077472079 no 1546 0.459536112140044 2148 17650701
SGTC_3046 9092212 49.47 µM 0.101446825130177 0.461773271125021 no 1547 0.459597883547236 2211 25236637
SGTC_276 colchicine 750 µM 0.101256289376038 0.461843290039372 no 1548 0.459673506909413 2135 2833 A microtubule depolymerizer.
SGTC_2074 5212007 75.395 µM 0.0995501369169969 0.462470326878807 no 1549 0.460350741030521 2240 758611
SGTC_2838 9002687 71.43 µM 0.0989703610923746 0.46268342457685 no 1550 0.46058090148042 2095 6457060
SGTC_2465 5809242 33.21 µM 0.0986766391352246 0.462791386727521 no 1551 0.460697508796497 2181 2731748
SGTC_2762 leflunomide 42.06 µM 0.0970304069159261 0.463396535922934 no 1552 0.461351123573054 2149 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2314 7727897 200 µM 0.0948660312183179 0.464192281521115 no 1553 0.462210618979623 2163 900724
SGTC_2148 5546263 113.568 µM 0.0927246377186456 0.464979718573844 no 1554 0.463061161631023 2144 792097
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0924995716566988 0.465062488288178 no 1555 0.463150565765807 2255 4114 Related to psoralen; DNA damaging agent.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0921854806421238 0.465178000115437 no 1556 0.463275336844882 2253 16725076
SGTC_1455 4262-0120 131 µM 0.0919880466601344 0.465250611017714 no 1557 0.463353768353261 2205 1529587
SGTC_920 mycophenolic acid 780.421 nM 0.0907373668389866 0.465710604158638 no 1558 0.463850639320661 2169 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_236 1509-0011 5.31 µM 0.0891995444254442 0.466276269500934 no 1559 0.464461663715898 2233 3107280
SGTC_100 0086-0128 49.5915 µM 0.088812338294844 0.466418708359534 no 1560 0.464615525950301 2145 93297
SGTC_1579 chlormadinone acetate 49.4 µM 0.0884759261721328 0.466542465468091 no 1561 0.464749208710927 2257 45114258 A steroidal progestin.
SGTC_1496 4469-0713 57.4 µM 0.0878511560791294 0.466772310409038 no 1562 0.464997489116862 2255 746691
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0870281229988809 0.467075110673263 no 1563 0.465324578994432 2239 279621
SGTC_435 c-PAF 6.7 µM 0.0870219152318669 0.4670773946316 no 1564 0.465327046175035 2258 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1368 1852-0141 284 µM 0.0864334399027742 0.467293911072877 no 1565 0.465560932594727 2176 2838987
SGTC_2016 5121758 140 µM 0.0857531632767959 0.467544215820157 no 1566 0.465831319776328 2257 2795203
SGTC_482 fipronil 114 µM 0.0853775318716726 0.467682433224592 no 1567 0.465980627450413 2257 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2280 7785178 200 µM 0.0849382313758479 0.467844083261745 no 1568 0.466155248676543 2189 2954328
SGTC_2892 9047358 58.44 µM 0.0819901702578637 0.468929021450932 no 1569 0.467327265067963 2186 6466771
SGTC_2301 7769476 200 µM 0.0817054090249427 0.469033830928697 no 1570 0.467440488482096 2202 977820
SGTC_181 1447-1644 8.07 µM 0.0809440168698915 0.469314080136219 no 1571 0.467743237194344 2258 534600
SGTC_2685 mycophenolic acid 18.85 µM 0.0802187313534381 0.469581053543987 no 1572 0.468031646352288 2238 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1574 spiramycin 23.7 µM 0.0796598146835487 0.469786796877302 no 1573 0.468253910538482 2257 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1439 4092-1168 46 µM 0.0786936322285814 0.470142478190593 no 1574 0.468638155259735 2242 2886240
SGTC_1506 4226-2149 212 µM 0.0778252657515298 0.470462170786707 no 1575 0.468983524117567 2159 991114
SGTC_883 0850-0245 24.6 µM 0.0767689815572888 0.470851071687693 no 1576 0.46940366351267 2218 6823229 YPR165W RHO1
SGTC_2543 pimpinellin 60.67 µM 0.0764206100139292 0.470979340638979 no 1577 0.469542236565519 2173 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2624 nerol 100 µM 0.075028226615969 0.471492040339158 no 1578 0.470096126794928 2250 637566 A natural product oil.
SGTC_39 0986-0283 58.349 µM 0.0723414195568917 0.472481502078339 no 1579 0.471165101492794 2267 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2919 7978188 46.38 µM 0.0717033146006658 0.472716520111547 no 1580 0.471419009142543 2280 2980291
SGTC_3276 9139060 49.47 µM 0.0716328825082937 0.47274246127378 no 1581 0.471447035413683 2306 4870619
SGTC_1096 rimcazole 32.2 µM 0.0697827070915211 0.473423948819494 no 1582 0.472183305680894 2231 18528119 A dopamine reuptake inhibitor.
SGTC_2477 5967686 25.23 µM 0.0675571660909643 0.474243800178998 no 1583 0.473069076982476 2256 776118
SGTC_3126 9127922 49.47 µM 0.0669056351574791 0.474483833864371 no 1584 0.473328413443105 2216 45595682
SGTC_2299 7976368 114.88 µM 0.0668837285752275 0.474491904736509 no 1585 0.473337133372741 2265 2979718
SGTC_1289 0976-0073 69.1 µM 0.0657844548909145 0.474896914984542 no 1586 0.473774716312541 2246 3391136
SGTC_2078 5212016 200 µM 0.0654372619732566 0.475024838211852 no 1587 0.473912928439047 2309 1899708
SGTC_1300 1094-0077 113 µM 0.0648712145228501 0.47523340390456 no 1588 0.474138269893107 2249 5532636
SGTC_3290 9121031 71.43 µM 0.0642450728253707 0.47546411981097 no 1589 0.474387544286906 2243 17014854
SGTC_2346 9031566 143.75 µM 0.0632922792662139 0.475815213657375 no 1590 0.474766881845729 2249 4771086
SGTC_1120 ficusin 1.78878 µM 0.0631637793101496 0.475862565907343 no 1591 0.474818043542222 2214 6199 A DNA cross-linker.
SGTC_1376 2910-0861 41.3 µM 0.0628287559200675 0.475986023670012 no 1592 0.474951433592863 2290 1112859
SGTC_1951 sophoraflavanone G 9.2 µM 0.0623856987179723 0.47614929596073 no 1593 0.475127841772491 2281 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2238 6671620 73.2395 µM 0.0611276994754675 0.476612906635313 no 1594 0.475628754701347 2306 729941
SGTC_2432 5630864 12.22 µM 0.0607658400761812 0.476746268631683 no 1595 0.4757728478482 2240 5714970
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0598160149968992 0.477096335643328 no 1596 0.476151085146503 2220 688803
SGTC_3201 9113999 49.47 µM 0.0589432434247919 0.477418019445488 no 1597 0.476498657316908 2271 16649224
SGTC_13 0199-0087 65 µM 0.0587261391211208 0.477498041460227 no 1598 0.476585119627608 2309 4589825
SGTC_2540 epiandrosterone 100 µM 0.0552018772002158 0.478797166303175 no 1599 0.477988816714212 2326 441302 A steroid.
SGTC_2229 7354935 190 µM 0.0549914065716449 0.478874757934002 no 1600 0.478072654998533 2307 318112
SGTC_866 0495-0101 262 µM 0.0516387474297019 0.480110847732595 no 1601 0.479408272263484 2243 635694
SGTC_931 2812-0076 566 µM 0.0512190714072743 0.480265591537121 no 1602 0.479575477502093 2324 3450959
SGTC_3302 9125395 16.351 µM 0.0503278040274774 0.480594231310767 no 1603 0.479930583714571 2238 17599668
SGTC_3080 9117754 49.47 µM 0.0492413242608173 0.480994870168941 no 1604 0.480363489597246 2331 9550191
SGTC_1236 0330-0013 258 µM 0.0485217788114632 0.481260212777164 no 1605 0.480650203950279 2271 4617066
SGTC_139 0099-0334 718.624 µM 0.0469440870287581 0.481842037935394 no 1606 0.481278895219165 2328 97690
SGTC_3183 9108214 49.47 µM 0.0464084240311754 0.482039589945096 no 1607 0.481492361171462 2316 4974831
SGTC_282 k297-0036 65.7 µM 0.0463843800414247 0.482048457449685 no 1608 0.481501943016945 2298 5061378
SGTC_3123 9126162 49.47 µM 0.0463177030630772 0.482073048190841 no 1609 0.481528514723816 2331 25239884
SGTC_470 aa-861 153 µM 0.0459372848583426 0.482213349275847 no 1610 0.481680118256298 2299 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0458196319605909 0.482256740993099 no 1611 0.481727005600608 2276 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3202 9113761 49.47 µM 0.0454950442339513 0.482376453700262 no 1612 0.481856362469426 2300 4798415
SGTC_2995 9067767 71.4286 µM 0.0452698746310034 0.482459500481572 no 1613 0.481946099686583 2268 11673567
SGTC_442 cape 100 µM 0.044647108342949 0.482689192345003 no 1614 0.482194296522987 2322 5281787
SGTC_3348 9149464 3.537 µM 0.0439609351544798 0.482942276917375 no 1615 0.482467771487771 2334 1951442
SGTC_1398 3558-0053 112 µM 0.043628002285141 0.483065076639027 no 1616 0.482600465173947 2286 4532369
SGTC_3115 9123671 49.47 µM 0.0430497191809768 0.483278375714734 no 1617 0.482830950194326 2346 3286988
SGTC_2374 9071832 200 µM 0.042782388835864 0.483376981834579 no 1618 0.482937501403961 2334 17381698
SGTC_341 1486-1430 230 µM 0.0419114469344089 0.48369824008264 no 1619 0.483284645541578 2337 2054753 YPL210C SRP72
SGTC_1355 1499-0035 1.68 µM 0.0409877782409745 0.484038958852869 no 1620 0.483652819613027 2339 1548538
SGTC_604 1000-0114 314 µM 0.039811109972679 0.484473019820912 no 1621 0.484121859388553 2337 1572745
SGTC_369 0957-0393 4.5 µM 0.0389084712033176 0.484806006589792 no 1622 0.48448168132057 2301 6997992
SGTC_490 phenamil 164 µM 0.0385911815361943 0.484923058446279 no 1623 0.484608166585819 2333 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3274 9138298 49.47 µM 0.0385700315778397 0.484930860958735 no 1624 0.484616597921234 2335 17015756
SGTC_522 1273-0010 11.6 µM 0.037802363337665 0.485214068282343 no 1625 0.484922630024877 2279 5705015
SGTC_1742 st038235 28.8875 µM 0.0375257963086945 0.485316100921768 no 1626 0.485032886074333 2283 564103 YBR002C RER2
SGTC_861 0443-0273 110 µM 0.0371712638250067 0.485446898413562 no 1627 0.485174225458676 2268 6149169
SGTC_589 1227-0070 34.1 µM 0.0369697226892404 0.485521253582866 no 1628 0.485254573511856 2301 2841384
SGTC_1227 3909-8010 46.6 µM 0.0364524923920963 0.485712079188879 no 1629 0.485460779544473 2290 15982272
SGTC_1241 0364-0022 50.8 µM 0.0356786415151436 0.485997587823002 no 1630 0.485769300654482 2303 4563895
SGTC_1903 st060211 78.3 µM 0.0342715082882207 0.48651676128559 no 1631 0.486330322305133 2340 688960
SGTC_2146 5545642 200 µM 0.0341574518582057 0.486558844363507 no 1632 0.486375797612208 2333 825326
SGTC_337 1315-0038 354 µM 0.0341117865851061 0.486575693391963 no 1633 0.48639400481004 2329 1626437
SGTC_684 1140-0066 328 µM 0.0311762756599308 0.48765885219465 no 1634 0.487564479998105 2298 6813534
SGTC_1758 st042942 75.2445 µM 0.030021533136584 0.488084959983437 no 1635 0.488024939974894 2344 669317
SGTC_1916 st067606 49.2 µM 0.0295551392289287 0.488257066368376 no 1636 0.488210921689018 2326 19590279
SGTC_2037 5169046 200 µM 0.0291613690094234 0.48840237522108 no 1637 0.488367945592736 2322 5718022
SGTC_1729 st035615 45.989 µM 0.0287754046508151 0.488544805053788 no 1638 0.488521858500258 2207 17385451
SGTC_1977 st070720 65.3 µM 0.0285910614360315 0.488612832507767 no 1639 0.488595370556207 2253 682188
SGTC_2038 4100038 30.985 µM 0.0277356978120043 0.488928488296656 no 1640 0.488936475955426 2327 3596803
SGTC_557 1315-0110 16.2 µM 0.0276062589831453 0.488976255860536 no 1641 0.488988094811323 2357 6833801
SGTC_2759 disulfiram 3.38 µM 0.0271727598707699 0.489136233707031 no 1642 0.48916097107764 2346 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_973 1325-0077 65.9 µM 0.0268514718031656 0.489254802491121 no 1643 0.489289099718103 2332 2835149
SGTC_2664 lyso-paf C-16 73.48 µM 0.0268248436220884 0.489264629450503 no 1644 0.489299719000232 2358 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2671 danthron 100 µM 0.0263171253379189 0.489452000865662 no 1645 0.48950219779877 2337 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1480 1070-0044 41.2 µM 0.0246274853350992 0.49007557232753 no 1646 0.490176047909064 2345 3124987
SGTC_1715 st032160 10.2275 µM 0.0240223639828965 0.490298901857822 no 1647 0.490417384987177 2347 5289825
SGTC_2174 5790901 200 µM 0.0239824429009117 0.490313635467258 no 1648 0.490433306607653 2339 786020
SGTC_1967 st070177 51.4 µM 0.023831648833838 0.490369288909825 no 1649 0.490493447547447 2345 5729214
SGTC_1668 st014914 51.6 µM 0.0226119729286376 0.490819440492427 no 1650 0.49097989662715 2355 2839556
SGTC_2156 5649887 115 µM 0.0214072531123776 0.491264083641452 no 1651 0.491460393872773 2341 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3319 9138450 16.7555 µM 0.0210686814791627 0.491389047087757 no 1652 0.491595433953129 2334 2029690
SGTC_1714 st033236 13.627 µM 0.0197749149408366 0.491866571219634 no 1653 0.49211146447381 2362 2916566
SGTC_1672 st016598 6.51 µM 0.0188767835153855 0.492198074885939 no 1654 0.492469700156051 2304 4665860 YNL267W PIK1
SGTC_1830 st055982 50.3 µM 0.0173874590479727 0.492747801879754 no 1655 0.493063756937258 2380 455313 An antimicrobial agent.
SGTC_3083 9117465 49.47 µM 0.016927633687498 0.492917531603175 no 1656 0.493247173714306 2286 16420915
SGTC_85 0868-0259 160.055 µM 0.0164052189916682 0.493110365718335 no 1657 0.493455558078558 2327 83173
SGTC_2960 9079389 5.97 µM 0.0142175406554429 0.493917900199916 no 1658 0.494328212990912 2389 16457355
SGTC_2466 5983409 37.09 µM 0.0128206029358833 0.49443356301052 no 1659 0.494885459540033 2315 2879657
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0124804325575495 0.494559134268396 no 1660 0.495021157027187 2385 2333 A French combination drug.
SGTC_2846 9008642 19.48 µM 0.0117425358291047 0.494831524961358 no 1661 0.495315513633966 2351 2992898
SGTC_2224 6650123 117.647 µM 0.0105699364073389 0.495264388771352 no 1662 0.495783283983855 2389 2908370
SGTC_302 1094-0063 18.9 µM 0.00812788076537336 0.496165888281271 no 1663 0.496757480414133 2386 5440289
SGTC_2191 5911152 200 µM 0.00756039452507944 0.496375382208162 no 1664 0.496983867700926 2382 2875902
SGTC_946 3434-1334 87.4 µM 0.00637756507627123 0.496812040145772 no 1665 0.497455736892354 2391 4047976
SGTC_1746 st038117 42 µM 0.00552160555919864 0.497128031915232 no 1666 0.497797209279903 2385 2898218
SGTC_1285 0929-0069 65.5 µM 0.00399754496614131 0.497690668701902 no 1667 0.498405214542744 2394 1206237
SGTC_2417 cerulenin 830 nM 0.00364937449300232 0.497819203329061 no 1668 0.49854411344929 2400 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3146 9095609 49.47 µM 0.00284644214737254 0.498115623934513 no 1669 0.498864435412131 2397 17173999
SGTC_1422 4031-0024 15.5 µM 0.00257708042872553 0.498215065136251 no 1670 0.498971894794986 2401 782427
SGTC_2008 4012253 172 µM 0.00236361720040835 0.498293870177132 no 1671 0.499057054042064 2399 603940
SGTC_1956 st077085 54 µM 0.00186506098292242 0.498477924347151 no 1672 0.499255948749743 2402 24208685
SGTC_1981 st071826 47 µM 0.00175730640405448 0.498517704618225 no 1673 0.499298936536631 2388 11838600
SGTC_3251 9135047 49.47 µM 0.00156539153548879 0.498588554780516 no 1674 0.499375499386162 2399 17682963
SGTC_1749 st037932 54.2 µM 0.000594024356103132 0.49894715984832 no 1675 0.499763018582699 2403 594497
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0 0.49916645958807 no 1676 0.5 2405 3256 An antibiotic and ribosome inhibitor.
SGTC_3306 9127676 59.7925 µM 0 0.49916645958807 no 1677 0.5 2405 41905287
SGTC_1401 3807-4679 7.6 µM -0.00157818057536517 0.499749087568034 no 1678 0.499370397303732 2404 3291456
SGTC_2492 derrusnin 100 µM -0.00293748622158945 0.499749087568034 no 1679 0.498828114233444 2401 1715307 Part of coumarin class of compounds.
SGTC_2257 7960413 200 µM -0.00376533723703252 0.49944346386314 no 1680 0.498497851325697 2420 2974689 YIL048W NEO1
SGTC_2031 5180455 200 µM -0.00390456485720113 0.499392064229886 no 1681 0.498442307949892 2414 29949
SGTC_1708 st033234 31.827 µM -0.004430968696778 0.499197728145056 no 1682 0.498232305028057 2416 674664
SGTC_69 0096-0274 206.684 µM -0.00455172934656784 0.499153146140016 no 1683 0.498184128984988 2450 6741392
SGTC_696 1560-0013 611 µM -0.00515904795755087 0.498928938497113 no 1684 0.497941846773009 2418 1650269
SGTC_2623 humulene 100 µM -0.00617951391993067 0.498552207438081 no 1685 0.497534746314878 2421 6187145 An anti-inflammatory.
SGTC_2812 7970281 58.44 µM -0.00644051941471562 0.498455850791056 no 1686 0.497430622260825 2419 2233435
SGTC_3004 9076122 71.4286 µM -0.00649588063987065 0.498435412834136 no 1687 0.497408536789425 2415 44782551
SGTC_2598 perillyl alcohol 100 µM -0.0069417975573648 0.498270791798757 no 1688 0.497230645694261 2425 10819 An apoptosis inducer.
SGTC_852 0418-0143 439 µM -0.00775989415469046 0.497968772401965 no 1689 0.496904281198897 2420 5369229
SGTC_1980 st071811 45.7 µM -0.00810281185395086 0.497842176689553 no 1690 0.496767481133499 2444 4974850
SGTC_1393 3470-5649 58.2 µM -0.00824128559124136 0.497791056083684 no 1691 0.496712239949613 2430 4108395
SGTC_3270 9137563 49.47 µM -0.00842646949739992 0.497722691455163 no 1692 0.49663836482539 2482 17015724
SGTC_3030 9087619 49.47 µM -0.0091484405925213 0.497456160928547 no 1693 0.496350351156904 2421 25236973
SGTC_2219 9098279 200 µM -0.0092128624404122 0.497432378327568 no 1694 0.49632465164106 2423 902349
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.01077706145018 0.496854926287186 no 1695 0.495700657753756 2429 16486 A toxic proline analog.
SGTC_1406 3909-7906 11.9 µM -0.0113616264971049 0.496639125271719 no 1696 0.495467464331289 2426 X1406
SGTC_1078 idebenone 36.1 µM -0.0127188553094353 0.496138087657815 no 1697 0.49492604766073 2446 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2170 morpholine 200 µM -0.0128689114319093 0.49608269296474 no 1698 0.494866188828249 2432 121171 Reacts with secondary amines.
SGTC_2713 st079149 53.4 µM -0.0130347996200609 0.496021453796897 no 1699 0.494800014566869 2440 3103253
SGTC_235 0330-0087 5 mM -0.0146554756126452 0.495423171331942 no 1700 0.494153520426843 2435 46494818 YHR062C RPP1
SGTC_563 tetrahydrosecaminediol 614 µM -0.0147406608225889 0.495391724963162 no 1701 0.494119540115578 2428 334274 A psychoactive constituent of the cannabis plant.
SGTC_3233 9132340 49.47 µM -0.0155870874302926 0.495079265698923 no 1702 0.493781903585409 2437 17682950
SGTC_2980 9014342 25.29 µM -0.0159840096075204 0.49493274249165 no 1703 0.493623574275681 2507 2996599
SGTC_559 1550-0661 158 µM -0.0163787803831318 0.494787014148984 no 1704 0.493466104140392 2460 5830875
SGTC_1157 4092-0394 27.6 µM -0.0171529362806092 0.494501239065322 no 1705 0.493157304032956 2453 3659885
SGTC_1521 st012942 49.4 µM -0.0197052049644547 0.493559104916509 no 1706 0.492139269312866 2474 24207259
SGTC_2683 piperine 63.03 µM -0.0198187397122753 0.493517195954203 no 1707 0.492093984345248 2445 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_99 0109-0120 622.8 µM -0.019890386621911 0.493490749042439 no 1708 0.492065406996944 2448 759414
SGTC_2634 4'-methoxyflavone 100 µM -0.0224140746457075 0.492559203126139 no 1709 0.491058826614477 2457 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2629 bisabolol 100 µM -0.0229742336093633 0.492352442087012 no 1710 0.490835413062198 2462 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2083 5306046 65.942 µM -0.0234325973369263 0.492183256352342 no 1711 0.4906526016124 2446 539837
SGTC_3332 9141069 11.198 µM -0.0234775103625498 0.492166678668871 no 1712 0.490634688835481 2455 17332883
SGTC_3157 9099274 49.47 µM -0.0249447002658738 0.491625137148315 no 1713 0.490049536328923 2449 17217662
SGTC_2157 5649910 96.377 µM -0.0250643491720991 0.49158097526343 no 1714 0.490001818241087 2441 2858091
SGTC_1935 st074532 41.6 µM -0.0252074558559552 0.4915281553516 no 1715 0.489944744967021 2564 2829742
SGTC_2849 9019321 12.99 µM -0.0266138111803598 0.491009085169292 no 1716 0.4893838787165 2493 16489627
SGTC_1633 st005664 67.9 µM -0.0283165801493625 0.490380632451768 no 1717 0.488704828427689 2460 2063822
SGTC_2397 5161689 200 µM -0.0285520805078112 0.490293716550499 no 1718 0.488610915350431 2474 2259942
SGTC_1673 st016611 27.3 µM -0.0295299642769037 0.489932814861517 no 1719 0.488220960660013 2512 5226799
SGTC_424 splitomicin 100 mM -0.0309284099241299 0.489416713321337 no 1720 0.487663316456809 2516 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2884 9058502 51.95 µM -0.0311358694032838 0.489340151121453 no 1721 0.487580591940437 2488 6471554
SGTC_3311 9131146 2.8755 µM -0.0341370614327224 0.488232616990146 no 1722 0.486383927473814 2515 4900406 YPR165W RHO1
SGTC_1254 0550-0035 264 µM -0.0342470061501387 0.488192045606757 no 1723 0.48634009150925 2495 15121435
SGTC_858 0438-0351 2.77 µM -0.0344882136183352 0.488103036568708 no 1724 0.486243920464223 2480 2799119
SGTC_2268 7933382 153.85 µM -0.0350174124029077 0.487907756659583 no 1725 0.486032928149089 2456 935025 YOR257W CDC31
SGTC_1397 3532-0190 20.1 µM -0.0357985425051714 0.487619516759852 no 1726 0.485721497618018 2467 5322280
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.0363446758959416 0.487417995348996 no 1727 0.485503763619985 2486 688801
SGTC_2431 5490079 200 µM -0.0368541616815951 0.487229999678354 no 1728 0.485300644287533 2488 5722345
SGTC_3186 9110464 49.47 µM -0.0368849200770078 0.487218650197614 no 1729 0.485288381800545 2499 17018021
SGTC_360 0957-0399 1.01 µM -0.037859731116452 0.48685896197187 no 1730 0.484899759963926 2499 6752301 YPR165W RHO1
SGTC_1468 k284-1086 134 µM -0.0389041628485072 0.486473596797911 no 1731 0.484483398805092 2481 15996457
SGTC_1022 4477-0945 21.3 µM -0.0392555720868987 0.486343939750117 no 1732 0.48434331381517 2467 4648966
SGTC_884 0851-0618 334 µM -0.0415606531019444 0.485493486294726 no 1733 0.483424470199152 2485 9642473
SGTC_1320 1313-0481 95.3 µM -0.0416785963912689 0.485449973176012 no 1734 0.483377458368801 2480 6813365 YLR208W SEC13
SGTC_719 2810-4230 27.3 µM -0.0418491837655938 0.485387038247312 no 1735 0.483309463177999 2471 721079
SGTC_2390 9097792 176.6 µM -0.0420343387461696 0.485318729292638 no 1736 0.483235661968753 2493 4497149
SGTC_2740 felodipine 17.08 µM -0.0422874493368582 0.48522535027207 no 1737 0.483134775157857 2497 3333 L-type calcium channel blocker
SGTC_1808 st050063 61.5 µM -0.0427806498728135 0.485043398214729 no 1738 0.482938194515269 2467 4011993
SGTC_2336 9001819 198.65 µM -0.0428702850751837 0.485010330235459 no 1739 0.482902468019835 2510 2989602
SGTC_328 k915-0120 63.5 µM -0.0430280452286412 0.484952130031845 no 1740 0.482839588845706 2541 6624543
SGTC_1306 1185-0270 9.02 µM -0.0453104858473434 0.484110138254755 no 1741 0.481929914763103 2501 1548076
SGTC_74 000s-0487 160.283 µM -0.0454918865324234 0.48404322257696 no 1742 0.481857620907134 2476 677548
SGTC_649 1123-0311 367 µM -0.0467058383852326 0.483595427707404 no 1743 0.481373838533747 2519 693629 YIL048W NEO1
SGTC_2329 6138490 200 µM -0.0470922684517806 0.483452888146888 no 1744 0.48121984469226 2676 720019
SGTC_899 1083-0020 478 µM -0.0480962470800941 0.483082568009781 no 1745 0.480819768571185 2595 767123
SGTC_2058 5236698 133 µM -0.0492050029180569 0.482673617496363 no 1746 0.480377962172983 2522 766665
SGTC_7 0192-1582 4.227 µM -0.0492473118305337 0.482658012749511 no 1747 0.48036110379707 2495 252616
SGTC_1128 3448-9350 235 µM -0.0496016675687631 0.482527317181164 no 1748 0.480219908870968 2579 619386
SGTC_3037 9091026 49.47 µM -0.050291646040442 0.482272840661589 no 1749 0.479944990420652 2507 25236398 YIL048W NEO1
SGTC_2761 levamisole 97.89 µM -0.0502988728078703 0.482270175337303 no 1750 0.479942111001786 2511 26879 An alkaline phosphatase inhibitor.
SGTC_1816 st051957 91.6 µM -0.0506583278435008 0.482137604723707 no 1751 0.4797988917749 2492 674121
SGTC_553 k007-0256 45.7 µM -0.0512286444793923 0.481927270300936 no 1752 0.479571663406028 2531 6287000
SGTC_526 4469-0568 170 µM -0.0517179009285932 0.481746835115761 no 1753 0.479376736724452 2495 2901964
SGTC_324 1315-0088 19.6 µM -0.0541558593406593 0.48084778544212 no 1754 0.478405494093108 2488 6787421
SGTC_2612 dictamnine 15.46 µM -0.0548610609341395 0.480587745126961 no 1755 0.478124577003742 2566 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2955 9076254 12.21 µM -0.0554905678898595 0.480355623886693 no 1756 0.477873822053572 2495 16459619
SGTC_3145 9085516 49.47 µM -0.0555361387559593 0.480338820571501 no 1757 0.477855669899932 2574 25236195
SGTC_822 1487-0950 154 µM -0.0564655351677874 0.479996132513846 no 1758 0.477485475327094 2507 1958375
SGTC_2571 chrysanthemic acid 100 µM -0.0569718313985982 0.47980945662046 no 1759 0.477283816985733 2555 2743 An insecticide.
SGTC_2532 xanthone 78.9 µM -0.0571149057309243 0.479756704650821 no 1760 0.477226831374886 2541 7020 An insecticide.
SGTC_1781 st038725 66.3 µM -0.0571527092929586 0.479742766414261 no 1761 0.477211774530525 2513 4270275 YIL048W NEO1
SGTC_1121 fusaric acid 630.51 nM -0.0582351669260087 0.479343673049588 no 1762 0.476780654543323 2545 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_478 N-arachidonylglycine 10 µM -0.0599382421848584 0.478715805066428 no 1763 0.476102410886891 2509 5283389
SGTC_1423 4048-0112 5.59 µM -0.0613283620120415 0.478203352563973 no 1764 0.475548851844787 2538 X1423
SGTC_2851 9015922 71.43 µM -0.0621933610397139 0.477884498246373 no 1765 0.475204424689833 2571 2996893
SGTC_874 0599-0792 117 µM -0.0626989355387357 0.477698140865457 no 1766 0.475003122522359 2509 765305
SGTC_1127 asiatic acid 681.4 nM -0.0628178510603793 0.477654308694681 no 1767 0.474955775425892 2516 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_881 0833-0569 170 µM -0.0629167654700051 0.477617849124488 no 1768 0.474916392189868 2520 5418700
SGTC_349 k015-0014 24 µM -0.0635932459865749 0.477368505366692 no 1769 0.474647054890052 2521 2196908
SGTC_2896 9052656 71.43 µM -0.0638759112563289 0.477264320475495 no 1770 0.474534516566163 2527 6469436
SGTC_261 5-fluorouridine 15.376 µM -0.0641529557535962 0.477162208798973 no 1771 0.474424218027988 2550 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2826 7992541 19.48 µM -0.064602892363219 0.476996376609536 no 1772 0.474245090875066 2501 2985066
SGTC_1089 terbinafine 2.25 µM -0.0653964298986859 0.47670391387585 no 1773 0.473929183262602 2566 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_653 0203-0016 55.2 µM -0.0662601505212944 0.476385599036609 no 1774 0.473585354373919 2582 295302
SGTC_2806 7952793 58.44 µM -0.0666358780211812 0.476247133445235 no 1775 0.47343579133964 2598 2972490
SGTC_2215 7188065 200 µM -0.0668302322433848 0.476175509862111 no 1776 0.473358427676901 2548 940217
SGTC_368 fentichlor 4.58 µM -0.0671653059801698 0.476052030012684 no 1777 0.473225052274189 2572 7329 A pesticide.
SGTC_1429 4049-0205 9.46 µM -0.0675314793068027 0.475917092114086 no 1778 0.473079301177511 2519 22774478
SGTC_1234 0326-0494 15.5 µM -0.068630513670061 0.475512105510447 no 1779 0.472641864863457 2622 1547813
SGTC_2278 7948257 134.34 µM -0.0692496315945706 0.475283975926206 no 1780 0.47239545879823 2527 1247028
SGTC_2583 asiatic acid 100 µM -0.0697872292633307 0.47508589110207 no 1781 0.472181505982912 2612 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3144 9087057 49.47 µM -0.0704033929166077 0.474858865200029 no 1782 0.471936295397442 2507 17249618
SGTC_2567 aureobasidin a 60 nM -0.0705822617572757 0.474792962383945 no 1783 0.471865114132591 2716 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3041 9091929 49.47 µM -0.0709017056935999 0.474675267497578 no 1784 0.471737992923488 2596 25236887
SGTC_26 0302-0163 425.158 µM -0.0730338127568896 0.473889777994135 no 1785 0.470889605328857 2556 3100915
SGTC_656 4090-1979 187 µM -0.0735745134445289 0.473690594482244 no 1786 0.470674475742746 2531 22330961
SGTC_507 nimesulide 162 µM -0.0753901657641124 0.473021792244896 no 1787 0.469952141763117 2618 4495 A COX2 inhibitor.
SGTC_2597 laccaic acid a 100 µM -0.0754882550515876 0.47298566284181 no 1788 0.469913120992288 2601 5491415 A textile dye.
SGTC_1442 4112-3290 3 µM -0.0765594846144845 0.472591109467005 no 1789 0.469486995452673 2539 704353
SGTC_1162 k048-0130 20.1 µM -0.0768932442572028 0.472468185183168 no 1790 0.469354235969219 2541 6797406
SGTC_2784 7567673 72.73 µM -0.0773187556046203 0.472311472383584 no 1791 0.469184985377524 2534 3471247
SGTC_766 1391-0721 126 µM -0.0791825633362641 0.471625096091802 no 1792 0.468443706741415 2582 1020919 YIL115C NUP159
SGTC_402 epigallocatechin gallate 10 µM -0.0798437051773241 0.471381640430557 no 1793 0.468180781777848 2555 65064 An antioxidant.
SGTC_2942 9052777 62.25 µM -0.0814246999379243 0.470799506129378 no 1794 0.467552103308034 2574 6469503
SGTC_201 4262-0159 12.803 µM -0.0814633207705762 0.470785286420542 no 1795 0.467536746840236 2615 1341029
SGTC_2693 st077581 40.7 µM -0.0819424695237004 0.470608872929916 no 1796 0.4673462310891 2547 25238761
SGTC_1676 st018489 23.4 µM -0.0820516612032149 0.47056867142854 no 1797 0.467302816107816 2610 3696235
SGTC_2929 9013348 24.6 µM -0.0824879074786219 0.470408060033456 no 1798 0.467129366998908 2627 2995952
SGTC_1736 st036774 51 µM -0.0827707221966673 0.470303939614138 no 1799 0.467016924762197 2616 1272247
SGTC_3162 9099653 49.47 µM -0.083315607519201 0.470103341610962 no 1800 0.466800295217788 2554 25237511
SGTC_166 k072-0058 166.424 µM -0.0835794643547841 0.47000620618039 no 1801 0.466695397434356 2542 5846229
SGTC_3173 9105693 49.47 µM -0.0840952448434262 0.469816333523576 no 1802 0.466490352659312 2645 17096658
SGTC_1392 3455-1037 33.9 µM -0.0848252207760646 0.469547621508744 no 1803 0.466200171259535 2667 981132
SGTC_506 n9-isopropylolomoucine 153 µM -0.0850860641140883 0.469451605619382 no 1804 0.466096484676638 2550 6610355
SGTC_1690 st023502 41.2 µM -0.0851904220593487 0.469413192174334 no 1805 0.466055002494986 2563 24207482
SGTC_989 1501-0895 10.3 µM -0.0866655792300918 0.468870227543232 no 1806 0.465468668616591 2540 2830112
SGTC_548 1436-0017 110 µM -0.0870603712052523 0.468724925294209 no 1807 0.465311762467027 2574 9677137
SGTC_406 estrone 100 µM -0.0871455630180245 0.468693571195596 no 1808 0.465277904533733 2587 5870 A steroid.
SGTC_1175 0741-0056 27.6 µM -0.0873532755120667 0.468617125250356 no 1809 0.465195354042773 2638 765927
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0878817157755981 0.46842264474618 no 1810 0.464985344533659 2682 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0911430407491536 0.467222556269835 no 1811 0.463689466685336 2630 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1804 st050076 49.1 µM -0.0918215668865271 0.466972912184542 no 1812 0.463419904274768 2647 3895976
SGTC_3282 9108498 15.4605 µM -0.0926514722265543 0.466667590168229 no 1813 0.463090225326555 2650 16459645
SGTC_11 0438-0307 1.3 µM -0.092855893466533 0.466592386636762 no 1814 0.463009023104748 2649 4011476
SGTC_633 0437-0093 97.7 µM -0.0928601550210121 0.466590818886982 no 1815 0.463007330304422 2553 2831118
SGTC_1917 st066507 28.5 µM -0.0931301364233904 0.466491498608728 no 1816 0.462900088033226 2556 3156428
SGTC_350 k064-0020 19.8 µM -0.0933117581474456 0.466424685105467 no 1817 0.462827945594686 2626 2790705
SGTC_626 0214-0009 33 µM -0.0934109330563399 0.466388201856474 no 1818 0.462788552586485 2651 3437874
SGTC_2716 st080858 38.6235 µM -0.0947747618253737 0.465886522036837 no 1819 0.462246866881775 2606 5296050
SGTC_995 3931-2021 34.6 µM -0.0964095291288538 0.465285249885312 no 1820 0.461597662114777 2656 730143
SGTC_417 st075190 100 µM -0.0966226184363886 0.465206880829346 no 1821 0.461513046810599 2571 222757
SGTC_2034 5197015 53.07 µM -0.0967685242552443 0.465153221001931 no 1822 0.461455110298827 2679 780676
SGTC_2880 9042983 58.44 µM -0.0972765313344017 0.464966396033896 no 1823 0.461253396439833 2699 6464714
SGTC_1055 3448-0672 86 µM -0.097288312072149 0.464962063634643 no 1824 0.461248718792227 2696 748378
SGTC_204 PMA1.184 62.41 µM -0.0975343826558929 0.464871571439504 no 1825 0.461151015485953 2555 2252213 YGL008C PMA1
SGTC_2831 7999036 19.48 µM -0.0990400090195509 0.464317918687206 no 1826 0.460553251821495 2813 2988270
SGTC_244 nsc-207895 1.295 µM -0.0993346916371973 0.4642095652965 no 1827 0.460436267338413 2568 42640
SGTC_96 0929-0093 37.281 µM -0.101022808187868 0.46358890430466 no 1828 0.459766177240622 2572 6991579
SGTC_1743 st037606 46.3785 µM -0.101927331704497 0.463256379232898 no 1829 0.459407177688027 2621 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_448 monastrol 171 µM -0.101994627475436 0.463231640676969 no 1830 0.459380469749571 2615 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_458 nppb 133 µM -0.10246879895153 0.463057334835606 no 1831 0.459192288645979 2637 4549 A chloride channel blocker.
SGTC_1238 0333-0287 48.8 µM -0.102803071397121 0.462934460258288 no 1832 0.459059633780309 2603 7226
SGTC_2163 5671233 125 µM -0.103490516965697 0.462681774567141 no 1833 0.458786837723824 2613 701023
SGTC_1698 5-fluorocytosine 1.055 µM -0.106007599752811 0.461756694876826 no 1834 0.457788161217344 2603 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2976 9009005 19.48 µM -0.106133674511023 0.461710365208844 no 1835 0.457738146814229 2627 2993148
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.107040843904977 0.461377016002557 no 1836 0.457378288563274 2561 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2472 5377652 49.4 µM -0.107581733317857 0.461178273234473 no 1837 0.457163743791256 2636 1610903
SGTC_2311 7694451 200 µM -0.109143812969782 0.46060436202342 no 1838 0.45654421235542 2666 2163142
SGTC_1973 st070275 50.2 µM -0.109395893736537 0.460511754699715 no 1839 0.456444245263312 2558 17118334
SGTC_1460 k062-0059 9.15 µM -0.109496566134146 0.460474771114493 no 1840 0.456404322611206 2538 1373085
SGTC_2994 9053520 71.4286 µM -0.109728780998333 0.460389464644199 no 1841 0.456312237149516 2686 4647384
SGTC_3234 9132280 49.47 µM -0.109797460139312 0.460364235018864 no 1842 0.456285002691138 2667 17612295
SGTC_1189 1431-2119 7.28 µM -0.110218993929261 0.460209385975653 no 1843 0.456117849535017 2582 3107275
SGTC_2287 7945887 168.79 µM -0.110725278662545 0.460023411932363 no 1844 0.455917099879907 2662 1245853
SGTC_926 2268-1401 59.4 µM -0.112217221655145 0.459475426132383 no 1845 0.455325587255212 2603 2931578
SGTC_412 gemfibrozil 100 µM -0.112456383212677 0.459387590003676 no 1846 0.455230775729382 2593 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_808 0711-0032 135 µM -0.11272202126118 0.459290032259562 no 1847 0.455125471038923 2583 4252555
SGTC_2079 5212404 121 µM -0.113073639380191 0.459160901402916 no 1848 0.454986086831931 2630 758462
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.113228375219627 0.459104076425341 no 1849 0.454924750074695 2570 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1259 0671-0132 43 µM -0.114988325331222 0.458457813838357 no 1850 0.454227187848038 2640 X1259
SGTC_594 1487-1584 10.8 µM -0.115656215144086 0.458212589965612 no 1851 0.453962504276042 2641 5013332
SGTC_6 0844-0013 19.835 µM -0.116147233875419 0.458032316601889 no 1852 0.453767927440104 2650 1584900
SGTC_2060 5238662 140 µM -0.116930047068553 0.457744931243204 no 1853 0.453457743677824 2703 790130
SGTC_3052 9092717 49.47 µM -0.117760489668665 0.457440084390026 no 1854 0.453128718165025 2757 25237534
SGTC_3015 9080845 49.47 µM -0.118418021935615 0.457198728876942 no 1855 0.452868223403699 2716 5296973
SGTC_1374 2889-5571 141 µM -0.118929655671961 0.45701093817585 no 1856 0.452665543333617 2672 2853281
SGTC_1888 azatryptophan 97.5 µM -0.120553765129606 0.456414886762212 no 1857 0.452022245868264 2737 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1097 itavastatin 7.23 µM -0.121242729124403 0.456162065145021 no 1858 0.451749390391276 2631 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1559 coumarin 343 70.1 µM -0.121700251940827 0.455994182777431 no 1859 0.451568206851004 2743 108770 A hepatotoxic, DNA x-linker.
SGTC_2932 9016711 44.54 µM -0.122313858052199 0.455769039904365 no 1860 0.451325228633245 2665 7117328
SGTC_936 3005-4620 401 µM -0.124563970630246 0.454943556107346 no 1861 0.450434376725248 2712 777207
SGTC_2033 5192550 145 µM -0.124647041563818 0.454913084129408 no 1862 0.45040149250008 2651 182073
SGTC_2383 9036125 200 µM -0.126748271743918 0.454142402157736 no 1863 0.449569819289817 2627 79580
SGTC_535 2293-4129 48.2 µM -0.127106902945826 0.454010881805917 no 1864 0.449427894009661 2697 396118 YIL048W NEO1
SGTC_3020 9089140 49.47 µM -0.128215914304496 0.453604207491182 no 1865 0.44898905311163 2687 17217859
SGTC_2210 7115885 190.385 µM -0.129310728330064 0.453202787049078 no 1866 0.448555891363989 2636 2927039
SGTC_1635 st007035 42.4 µM -0.129494258521326 0.453135499219577 no 1867 0.448483283869472 2617 3716403
SGTC_854 0422-0053 192 µM -0.129900155946598 0.452986689484063 no 1868 0.448322710453587 2646 3596728
SGTC_2334 9017922 200 µM -0.130722357690228 0.452685274900966 no 1869 0.447997472616071 2781 3163164
SGTC_2630 antimycin a 100 µM -0.131885077697402 0.45225907479409 no 1870 0.447537595897096 2601 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_171 k064-0041 9.68 µM -0.132119551541666 0.452173134029357 no 1871 0.447444865789757 2660 53325
SGTC_90 0870-0863 4.608 µM -0.133406162864773 0.451701597493285 no 1872 0.446936085857135 2621 1738164
SGTC_1445 4239-0156 97.7 µM -0.134110811079696 0.451443376322766 no 1873 0.446657475434217 2816 4008346
SGTC_1177 0983-0204 23.6 µM -0.13415548778374 0.451427005056433 no 1874 0.446639811625885 2742 766818
SGTC_1003 4049-0218 100 µM -0.13499131954306 0.45112073934475 no 1875 0.44630936875566 2776 295161
SGTC_707 0865-0008 204 µM -0.13531019626136 0.451003904104377 no 1876 0.446183311884437 2660 723043
SGTC_1211 1056-0033 32.3 µM -0.135683003096678 0.450867314453384 no 1877 0.446035942505844 2665 6741922
SGTC_2321 7390090 138.78 µM -0.135951672224716 0.45076888257264 no 1878 0.445929743058543 2727 649046
SGTC_2127 5253358 187.912 µM -0.136086948514011 0.450719322759508 no 1879 0.445876272557789 2636 20612
SGTC_1794 st048918 76.9 µM -0.136222261452765 0.450669750288128 no 1880 0.445822788555395 2606 672303
SGTC_1222 0366-0074 1.18 µM -0.136474238146993 0.450577439604377 no 1881 0.445723194483708 2740 286520
SGTC_222 nsc-310342 10.666 µM -0.138298468942407 0.449909219777979 no 1882 0.445002267745409 2642 432556
SGTC_2459 5811157 9.22 µM -0.13859055285374 0.449802241926031 no 1883 0.444886854497132 2628 2870684 YBR192W RIM2
SGTC_509 pifithrin 175 µM -0.138729575339534 0.449751325212712 no 1884 0.444831923167793 2654 4817 A p53 inhibitor.
SGTC_343 4130-2827 29.8 µM -0.139345693368881 0.449525683158735 no 1885 0.444588491988664 2691 1118244
SGTC_1198 1612-1005 86.7 µM -0.139629736710744 0.44942166292821 no 1886 0.444476272138975 2833 6998509
SGTC_1167 k781-0610 148 µM -0.139758827190897 0.449374389525356 no 1887 0.44442527253972 2704 4525169
SGTC_1966 st070145 16.1 µM -0.140004145561326 0.449284555027602 no 1888 0.44432835748335 2631 3748532
SGTC_345 1362-0200 395 µM -0.140254334732621 0.449192939541709 no 1889 0.444229521605085 2682 1419823
SGTC_840 0245-0196 390 µM -0.142033374671292 0.448541560448621 no 1890 0.443526821870023 2782 3827528
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.142120271920517 0.448509747359504 no 1891 0.443492503014326 2780 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1039 k821-0043 94 µM -0.142609868699912 0.448330512137638 no 1892 0.443299151528333 2669 15992768
SGTC_383 2324-0395 7.37 µM -0.142679114285742 0.44830516305025 no 1893 0.443271806160681 2787 3146421
SGTC_3333 9141820 12.094 µM -0.142987552235009 0.448192254150838 no 1894 0.44315000602508 2710 1939433
SGTC_164 4100-3994 89.624 µM -0.144016299255293 0.447815694393882 no 1895 0.442743799432946 2650 4615967
SGTC_2835 9006588 71.43 µM -0.144688163131428 0.447569792533526 no 1896 0.442478542631242 2895 2345538
SGTC_2969 9091408 28.7 µM -0.145641084524681 0.447221058334576 no 1897 0.442102366502005 2696 4286311
SGTC_1854 st056233 32.9 µM -0.147895975153007 0.446396014245562 no 1898 0.441212432319511 2650 5393174
SGTC_2126 5251174 33.877 µM -0.150238376691918 0.445539196422335 no 1899 0.440288274633872 2765 790722
SGTC_699 0375-0592 111 µM -0.150374795293645 0.445489304197881 no 1900 0.44023446279246 2682 762578
SGTC_430 0958-0115 16.4 µM -0.150538841020132 0.445429309078932 no 1901 0.440169754584994 2708 6833180
SGTC_1170 0310-0127 64.8 µM -0.152053652184112 0.44487536864987 no 1902 0.439572309625123 2749 774975
SGTC_1418 3966-3099 2.4 µM -0.152811182321135 0.444598393190684 no 1903 0.439273589546209 2716 740335
SGTC_284 0988-0104 32.6 µM -0.153173260238336 0.444466016324044 no 1904 0.439130822025057 2778 4666532
SGTC_1909 st060837 51.5 µM -0.154078022502069 0.444135259400956 no 1905 0.438774108420449 2732 678937
SGTC_919 tnp00227 403.569 nM -0.154207375483142 0.444087974578638 no 1906 0.438723113479271 2735 1269246 A methoxyflavone. YNL221C POP1
SGTC_197 4544-0043 41.561 µM -0.154392809572095 0.44402019076508 no 1907 0.438650011407394 2691 896523
SGTC_1499 4480-0877 67.3 µM -0.154925546638675 0.44382546249465 no 1908 0.4384400067479 2683 2861909
SGTC_1885 st057546 99.9 µM -0.155814726787939 0.443500475896473 no 1909 0.438089531055614 2839 702008
SGTC_2187 6125751 200 µM -0.156639666627092 0.443199002473519 no 1910 0.4377644194803 2725 874498
SGTC_118 0083-0097 135.343 µM -0.157092839801282 0.443033404779279 no 1911 0.437585840265501 2706 5207356
SGTC_2095 5432005 200 µM -0.159371195691581 0.442201003571254 no 1912 0.436688215674049 2729 783734
SGTC_2015 5119600 184 µM -0.16015031177347 0.441916410539054 no 1913 0.436381334768757 2837 2828786
SGTC_741 4582-0002 126 µM -0.160661041194066 0.441729869186727 no 1914 0.436180187683871 2688 2912688
SGTC_1049 3226-0134 66 µM -0.162151629551649 0.441185513331649 no 1915 0.435593224812729 2646 5702385
SGTC_330 1488-0319 80.1 µM -0.162673287734912 0.440995032407806 no 1916 0.435387840051414 2756 6846614
SGTC_1101 ebselen 5.29 µM -0.16580722429494 0.43985097970691 no 1917 0.434154330328924 2748 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1879 gemcitabine 100 µM -0.166597324287293 0.43956263026559 no 1918 0.43384344959278 2711 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1552 6-methylflavone 10.6 µM -0.168262835812887 0.438954901876247 no 1919 0.433188254844925 2702 689013
SGTC_2518 prenyletin 46.28 µM -0.169445702211779 0.438523373126825 no 1920 0.432723039013492 2764 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1469 k284-2957 126 µM -0.169595251775986 0.438468820225558 no 1921 0.432664228494056 2734 23884841
SGTC_51 1013-0126 23.419 µM -0.169679259772372 0.43843817618272 no 1922 0.432631192917553 2815 1627850
SGTC_1302 1159-0335 255 µM -0.170611257802502 0.438098231114945 no 1923 0.43226472263698 2687 649284
SGTC_1263 0774-1208 64.8 µM -0.171345610482486 0.437830409090932 no 1924 0.431976009371055 2811 906585
SGTC_1663 st014140 55.4 µM -0.171370330029938 0.437821394245485 no 1925 0.43196629142762 2716 4207120
SGTC_953 1188-0045 9.7 µM -0.171991332655454 0.437594934572268 no 1926 0.431722171501001 2822 6144426
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.172553196866421 0.437390058386699 no 1927 0.431501321710237 2900 94937 An inhibitor of serotonin biosynthesis.
SGTC_2380 9035439 200 µM -0.173259714748283 0.437132460028294 no 1928 0.431223643857769 2847 6462575
SGTC_246 cycloheximide 667 µM -0.174886935070494 0.43653927258282 no 1929 0.430584238182272 2704 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_475 α-linolenic acid 10 µM -0.175054794954427 0.436478088979953 no 1930 0.43051828905334 2950 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_809 3998-0021 90 µM -0.176248164432883 0.436043159115263 no 1931 0.430049491617978 2778 715485
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.177855005647489 0.435457659523505 no 1932 0.429418423832043 2716 1377
SGTC_25 0118-0223 35.662 µM -0.178719880066525 0.435142575712226 no 1933 0.429078829234312 2825 5333628
SGTC_1616 st002734 56.1 µM -0.180912800625819 0.434343854258561 no 1934 0.428218010599119 2755 4026101
SGTC_1112 tnp00069 1.16933 µM -0.181048337378806 0.434294496836575 no 1935 0.428164817571595 2846 145826
SGTC_1028 k015-0029 4.8 µM -0.181082815116816 0.43428194149581 no 1936 0.428151286577187 2710 4588309
SGTC_2563 tomatine 8.54 µM -0.181519403407869 0.434122960157989 no 1937 0.427979952205314 2709 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2018 5133068 143 µM -0.181735094473484 0.434044421317586 no 1938 0.427895311578964 2719 785362
SGTC_621 3584-0052 32.1 µM -0.18187424116848 0.433993755695041 no 1939 0.427840709949077 2755 2273927
SGTC_1656 st012921 11 µM -0.183798553689144 0.433293193098067 no 1940 0.427085745399184 2850 6732821
SGTC_748 act1.228 77.9 µM -0.184038380523685 0.433205896708307 no 1941 0.426991672914066 2734 4421505 YNR035C ARC35
SGTC_1386 3228-0095 33.8 µM -0.184682850588816 0.432971327315263 no 1942 0.426738899015794 2868 870181
SGTC_813 k007-0158 173 µM -0.18471189065214 0.432960758085678 no 1943 0.426727509636526 2822 6523916
SGTC_968 1309-0633 340 µM -0.18478911683762 0.432932651586783 no 1944 0.426697222179057 2813 3761976
SGTC_309 k408-0051 1.48 µM -0.184880632375134 0.432899344912172 no 1945 0.426661331118039 2771 3640463
SGTC_1863 st057641 20.1 µM -0.186098375761095 0.43245619806227 no 1946 0.426183807810473 2720 3921635
SGTC_454 lyso-paf C-16 6.67 µM -0.186213413323751 0.432414339328486 no 1947 0.426138702807792 2804 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_113 0099-0221 2.5 µM -0.188352575123393 0.431636100922689 no 1948 0.425300136907095 2856 89219
SGTC_2458 5808907 16.39 µM -0.188900336286628 0.431436865046476 no 1949 0.425085465001244 2780 2731747
SGTC_903 1134-0042 114 µM -0.189550424340115 0.431200432689833 no 1950 0.424830719210684 2751 701009
SGTC_1385 3091-4834 14.1 µM -0.191181419838857 0.430607360027363 no 1951 0.42419172997375 2854 4072814
SGTC_2153 5569715 200 µM -0.191459685198663 0.430506191046756 no 1952 0.424082731391324 2754 2054701
SGTC_2819 7996655 46.38 µM -0.191494252272543 0.430493623808631 no 1953 0.424069191620264 2831 6456960
SGTC_3035 9091303 49.47 µM -0.192974546325145 0.42995551292104 no 1954 0.423489451242986 2743 25237002
SGTC_2186 6124449 200 µM -0.193487067316207 0.429769233496872 no 1955 0.423288766737141 2898 3834182 YLR033W RSC58
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.194517183941983 0.429394877563232 no 1956 0.422885470925908 2893 551469
SGTC_2640 pentamidine 10.38 µM -0.195017094719843 0.429213227240387 no 1957 0.422689782452042 2849 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1274 0865-0114 173 µM -0.195031904288513 0.429207846182681 no 1958 0.4226839855845 2797 870624
SGTC_941 3237-0776 460 µM -0.196030308423764 0.428845106366352 no 1959 0.422293221755512 2921 760008
SGTC_775 4577-0580 57.3 µM -0.196766896429032 0.428577527991556 no 1960 0.422004978730975 2960 2006902
SGTC_1333 1482-0047 286 µM -0.197155113497067 0.428436514607562 no 1961 0.421853077687524 2830 3811116
SGTC_1945 st075991 56.6 µM -0.197390293594148 0.428351093797112 no 1962 0.42176106239411 2811 1084980
SGTC_1354 1498-1681 81 µM -0.20427840542153 0.42585073734619 no 1963 0.41906797206962 2840 5754243
SGTC_2276 7947513 42.08 µM -0.208143772543311 0.424448922956879 no 1964 0.417558354991719 2851 2105100
SGTC_1889 st059080 5.18 µM -0.208321334180017 0.424384551248311 no 1965 0.417489037390133 2802 176925 Isolated from Daphnopsis sellowiana.
SGTC_2951 9072950 58.06 µM -0.209987394208609 0.423780650275632 no 1966 0.41683875583177 2782 16488155
SGTC_964 1287-0107 19.4 µM -0.211692523580511 0.423162773048378 no 1967 0.416173460618624 2918 51516812 YPR165W RHO1
SGTC_1251 0490-5699 265 µM -0.212006724239335 0.423048938661091 no 1968 0.416050894190435 2903 3883818
SGTC_2850 9015429 58.44 µM -0.214263494236699 0.422231503905901 no 1969 0.415170792162044 2848 6457570
SGTC_3192 9110362 49.47 µM -0.214425381605025 0.422172878788909 no 1970 0.415107675137681 2728 16649480
SGTC_151 3013-0144 2.285 µM -0.214946259543248 0.421984262250516 no 1971 0.414904608906887 3005 906558 YHR107C CDC12
SGTC_2924 9010168 62.78 µM -0.215720066666297 0.421704089879825 no 1972 0.414602979267557 2880 2993929
SGTC_2303 7774051 200 µM -0.215833532471897 0.421663010639917 no 1973 0.414558754580142 2959 2953184
SGTC_3200 9114385 49.47 µM -0.215864900735259 0.421651654202225 no 1974 0.414546528606381 2934 17018030 YLR208W SEC13
SGTC_2523 spermine 47.74 µM -0.217241509236659 0.42115333680248 no 1975 0.414010068665466 2900 1103 A DNA binding polyamine.
SGTC_3318 9139014 38.6185 µM -0.217641732914323 0.421008483814892 no 1976 0.413854132829282 2781 16643984
SGTC_413 propylparaben 100 µM -0.217995459684748 0.420880468357319 no 1977 0.413716324504124 2783 7175 A pharmaceutical preservative.
SGTC_1141 3253-0389 52.6 µM -0.21923891833034 0.420430521038289 no 1978 0.413231970199133 2793 5402031
SGTC_463 ikarugamyin 104 µM -0.221136356583678 0.419744130769118 no 1979 0.41249313122968 2788 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3257 9139206 32.98 µM -0.221150011068251 0.419739192199114 no 1980 0.412487815462623 2904 4910041
SGTC_2057 5236571 38.335 µM -0.22293220720338 0.41909471418263 no 1981 0.411794134684718 2950 54684039 YBR257W POP4
SGTC_2727 riluzole 51.77 µM -0.223237091189241 0.418984483684668 no 1982 0.411675492820282 2788 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_916 4466-0038 42 nM -0.223441022884222 0.418910755934796 no 1983 0.411596139808081 2958 5722064 YGL116W CDC20
SGTC_2795 7780010 54.55 µM -0.223897686637167 0.418745667894629 no 1984 0.411418457917813 2933 953673
SGTC_3077 9117319 49.47 µM -0.226097387557112 0.417950657253626 no 1985 0.410562838207166 2781 17154678
SGTC_2682 pyrogallin 40.03 µM -0.227486267161503 0.417448864120511 no 1986 0.410022823278329 2842 822798 An ATP competetive kinase inhibitor.
SGTC_3254 9136651 49.47 µM -0.229111232385923 0.41686194546349 no 1987 0.409391231732409 2812 16454030
SGTC_746 1095-0025 46.6 µM -0.231677707123146 0.415935342289851 no 1988 0.408394173735454 2998 6749286
SGTC_624 k048-0052 28 µM -0.233556460769506 0.415257330612472 no 1989 0.407664666084595 2864 6835531
SGTC_617 3770-0098 35 µM -0.234278657161358 0.414996768679696 no 1990 0.407384327011229 2833 5962639
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.234300317324767 0.414988954465355 no 1991 0.407375919794506 2872 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1655 st012546 55.1 µM -0.234386616308223 0.414957821204378 no 1992 0.407342423967801 2913 720985 YLR208W SEC13
SGTC_1516 st013856 110 µM -0.23456250159382 0.414894370401512 no 1993 0.407274158482286 2946 5281404 A mutagen and neurotoxin.
SGTC_217 ketoconazole 989 nM -0.235146814044078 0.414683595014368 no 1994 0.40704739241273 2896 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_403 arphamenine a 50 µM -0.235908515535827 0.414408868069951 no 1995 0.406751830143582 2817 5487158 An arginine aminopeptidase inhibitor.
SGTC_206 4546-0025 72.014 µM -0.236076371584779 0.41434833215758 no 1996 0.406686704263768 2875 6620745 YIL048W NEO1
SGTC_2696 st077691 74.316 µM -0.23652197296042 0.414187639536118 no 1997 0.406513829472019 2963 757133
SGTC_2791 5663188 71.43 µM -0.236621402528015 0.414151785237413 no 1998 0.406475257422254 2991 54690634
SGTC_3031 9088762 49.47 µM -0.237883227021746 0.413696833619721 no 1999 0.405985832517898 2784 205253
SGTC_3297 9117502 71.43 µM -0.239813936544795 0.413000939468963 no 2000 0.405237251198813 2842 7453720
SGTC_1325 1431-0015 227 µM -0.242522331588224 0.412025201719639 no 2001 0.404187727575602 2836 1103340
SGTC_80 0159-0065 512.242 µM -0.242840559941226 0.411910591013729 no 2002 0.4040644567786 2791 1548079
SGTC_316 k060-0003 58.6 µM -0.244714858567243 0.411235710627192 no 2003 0.403338611160001 2983 6152314
SGTC_2499 avocadenofuran 51.48 µM -0.246062234485278 0.410750721889978 no 2004 0.402817028460579 2821 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2158 5657123 3.6195 µM -0.24660567663526 0.41055514814028 no 2005 0.402606705447281 2810 2858827
SGTC_1833 st055984 71 µM -0.248812489413784 0.409761190214177 no 2006 0.401752914856957 2884 676288
SGTC_843 0310-0051 143 µM -0.249386905095679 0.409554589864935 no 2007 0.401530756723087 2887 2065037
SGTC_1490 4089-0339 670 nM -0.249913907164079 0.409365064879795 no 2008 0.40132696403002 2883 742542
SGTC_630 4356-0227 183 µM -0.249998750451727 0.409334554790411 no 2009 0.401294157477629 2863 779312
SGTC_1795 st049545 62.3 µM -0.250148337314167 0.409280763911144 no 2010 0.401236318070882 2895 5291882
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.250463271870558 0.409167520201003 no 2011 0.401114552234705 2829 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1149 3909-7961 23.3 µM -0.250683160125081 0.40908845759532 no 2012 0.401029540654923 2858 735261
SGTC_1488 4013-0813 75.9 µM -0.25098896521697 0.408978509042719 no 2013 0.400911320330175 2848 2910057
SGTC_359 0081-0058 15.9 µM -0.251727984847752 0.40871283298056 no 2014 0.400625662302326 3253 3494159
SGTC_2439 5492030 7.2 µM -0.252251649979327 0.40852460180749 no 2015 0.400423278796688 2975 5722370
SGTC_1632 st005650 90 µM -0.252330830917134 0.408496142093943 no 2016 0.400392679665466 2975 2759605
SGTC_2965 9082772 38.63 µM -0.253764259428776 0.407981013737433 no 2017 0.399838843301682 3025 16459634
SGTC_1864 st057645 30.4 µM -0.253804890034769 0.407966414710676 no 2018 0.3998231477116 2884 688666
SGTC_671 0560-0003 407 µM -0.253879976586274 0.407939435617332 no 2019 0.399794142226766 2896 3238678
SGTC_2251 lansoprazole 556 µM -0.255556132421191 0.407337295624717 no 2020 0.399146797493481 2843 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2986 9022445 71.43 µM -0.256144702322362 0.4071259104103 no 2021 0.398919552788253 3063 6459286
SGTC_1701 st028638 40.4 µM -0.259254586010686 0.406009444348229 no 2022 0.397719408411498 2978 3490878
SGTC_999 SEC7.066 22.7 µM -0.260815479638879 0.405449361960931 no 2023 0.397117403238787 2868 740511 YDR170C SEC7
SGTC_880 0833-0487 87.2 µM -0.264441748046999 0.404148927400279 no 2024 0.395719772889256 2867 76075
SGTC_2436 5633522 8.09 µM -0.264728296687551 0.404046211673937 no 2025 0.395609388674274 3035 5724242
SGTC_2608 thymoquinone 42.66 µM -0.266975521129524 0.403240905425184 no 2026 0.394744004271161 2909 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2371 9071574 200 µM -0.268135632707598 0.402825332849737 no 2027 0.394297459400784 2978 45596039
SGTC_2069 5228469 200 µM -0.270347691504686 0.402033238627523 no 2028 0.393446389142676 3004 2835210
SGTC_1098 clofazimine 15.1 µM -0.271273936645275 0.401701687952602 no 2029 0.393090175341591 2997 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1058 3448-5425 97.3 µM -0.271714051235962 0.401544173129636 no 2030 0.392920948158416 2847 7279705
SGTC_939 1165-0479 45.3 µM -0.272793556532605 0.401157891336641 no 2031 0.392505956461961 3014 1377347
SGTC_667 1498-1044 59 µM -0.273945321207961 0.400745859326387 no 2032 0.392063321004516 2926 6739982
SGTC_2752 diclazuril 33.15 µM -0.274196041346521 0.400656181382249 no 2033 0.391966985067545 3038 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1769 st044406 64.4 µM -0.274946146460598 0.400387913975735 no 2034 0.391678806546993 2886 670903
SGTC_1770 st043884 66.3 µM -0.277177348156397 0.399590225767461 no 2035 0.390821966012343 2875 670149
SGTC_1432 4049-0298 68.4 µM -0.277368928647138 0.399521752340254 no 2036 0.390748418670451 3006 741646
SGTC_2090 5301565 104.445 µM -0.27822317958352 0.399216469282547 no 2037 0.390420521156519 2906 2056344
SGTC_1870 st057514 26.5 µM -0.278722184349857 0.399038168800235 no 2038 0.390229018134857 2858 5393161
SGTC_1197 1601-0112 267 µM -0.278900077808737 0.398974610391181 no 2039 0.390160754412936 2884 7350313
SGTC_1349 flufenamic acid 69 µM -0.279002111425784 0.398938156665434 no 2040 0.39012160219991 2870 3371 A non-steroidal anti-inflammatory.
SGTC_3018 9082602 49.47 µM -0.280203111881 0.398509139501122 no 2041 0.389660839664698 2901 17332089
SGTC_1206 3978-0017 132 µM -0.282326785006172 0.397750828869776 no 2042 0.388846474571589 3178 3873677
SGTC_2223 6903751 107.57 µM -0.284915934805038 0.396826830776556 no 2043 0.38785427376791 3005 5598863
SGTC_169 k015-0017 16.025 µM -0.28517655434279 0.396733854642524 no 2044 0.38775444090493 3130 1840002
SGTC_1440 4100-1550 40 µM -0.287968700119853 0.395738124791528 no 2045 0.386685348969964 2936 742806
SGTC_2820 7989630 71.43 µM -0.288515139875975 0.395543333826956 no 2046 0.386476221531641 2980 2984098
SGTC_1691 st019933 84.6 µM -0.289781085166423 0.395092158955654 no 2047 0.385991859572157 3002 6176082
SGTC_2168 5727979 200 µM -0.293373951502621 0.393812451921632 no 2048 0.384618166815682 2864 695210
SGTC_647 0140-0236 81 µM -0.293967162942061 0.393601271735277 no 2049 0.38439149773723 2971 990837
SGTC_1275 0867-0008 21.1 µM -0.297154615121223 0.392467092602009 no 2050 0.38317423477033 2892 3422836
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.297167523865279 0.392462501181342 no 2051 0.383169307357686 2951 1241132 A phosphatase inhibitor.
SGTC_1796 st049173 110.4 µM -0.298139852730743 0.392116703413084 no 2052 0.382798212890768 3036 94134
SGTC_911 3456-4043 236 µM -0.301553728302485 0.390903273452678 no 2053 0.38149614308945 3027 914281
SGTC_1734 st037168 69.4 µM -0.302147793474635 0.390692226666719 no 2054 0.381269700024766 3020 708907
SGTC_2284 7945075 39.21 µM -0.3044528905213 0.389873626384719 no 2055 0.380391439061405 3077 1245402
SGTC_397 arbidol 50 µM -0.306549936748411 0.389129334368559 no 2056 0.379592982298049 3095 131410 A RNA synthesis inhibitor.
SGTC_2449 5812982 45.77 µM -0.307102224051991 0.388933381893189 no 2057 0.37938278245288 3031 776185
SGTC_1185 1319-0113 81.3 µM -0.307582050886551 0.388763161447104 no 2058 0.379200189907794 3042 4672763
SGTC_2244 6635614 200 µM -0.309178298671658 0.388197040157504 no 2059 0.378592950439525 2876 836499
SGTC_2373 9071805 200 µM -0.309578326858091 0.38805520431764 no 2060 0.378440819894474 3104 10149009
SGTC_1466 k213-0079 57.5 µM -0.30993425750688 0.387929016456679 no 2061 0.378305475461198 2950 3657981
SGTC_3240 9133527 49.47 µM -0.312546726449278 0.387003182534152 no 2062 0.377312528851262 2981 17617455
SGTC_1866 st057638 64 µM -0.314432694045643 0.386335212743608 no 2063 0.376596214065085 2970 688802
SGTC_774 k060-0086 136 µM -0.314927776427307 0.386159920763241 no 2064 0.376408245675404 3138 5911235
SGTC_3119 9125183 49.47 µM -0.315023023982463 0.386126199479133 no 2065 0.376372086307273 2997 22695334
SGTC_1737 st035557 69.7 µM -0.315215687279924 0.386057991919746 no 2066 0.376298947767048 2923 5716916
SGTC_1457 k015-0032 57.3 µM -0.316511041308546 0.385599496179325 no 2067 0.375807322934889 2932 4302660
SGTC_2933 9026794 32.47 µM -0.316663516871388 0.385545537344299 no 2068 0.375749467230645 3008 17586027
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.31821246182982 0.384997514468315 no 2069 0.375161890263978 3036 77254
SGTC_275 trichlorophene 5.69 µM -0.319288567554101 0.384616919107941 no 2070 0.374753850565117 3068 62616
SGTC_2663 amphotericin b 100 µM -0.319575906612047 0.384515312278956 no 2071 0.374644920519626 2995 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_632 0781-2353 4.65 µM -0.320183936233391 0.384300331257709 no 2072 0.374414449881482 3068 6811515 YHR007C ERG11
SGTC_1886 st057356 49.9 µM -0.321319697228028 0.383898855629608 no 2073 0.373984065491436 2953 24207747
SGTC_615 k087-0205 167 µM -0.321347666432988 0.383888970476706 no 2074 0.373973468841777 2980 9642773
SGTC_845 0330-0138 4.51 µM -0.321988147442663 0.383662626032257 no 2075 0.373730836863664 3038 9039800
SGTC_890 0929-0006 47.2 µM -0.321997301865608 0.383659391168783 no 2076 0.373727369276696 2973 1378169
SGTC_2521 angolensin 13.4 µM -0.322107428084644 0.383620476922887 no 2077 0.373685655570639 3130 821428 A flavenoid.
SGTC_2916 7875993 68.79 µM -0.323134474147887 0.383257616073148 no 2078 0.373296701467634 3044 1299250
SGTC_888 0916-0002 6.97 µM -0.323341517343408 0.383184478999646 no 2079 0.373218307458545 3150 2802138 YIL048W NEO1
SGTC_172 1112-0046 2.638 µM -0.324002926198442 0.382950867215998 no 2080 0.372967909425065 2993 2802135 YIL048W NEO1
SGTC_2419 paclitaxel 166.5 µM -0.324839869387478 0.382655317151823 no 2081 0.37265113402276 2882 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1075 aripiprazole 15.2 µM -0.326661260582197 0.382012364944291 no 2082 0.371962051863085 2950 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1427 4048-4900 550 nM -0.326719875400094 0.381991679270552 no 2083 0.371939883068897 3099 24132586
SGTC_2116 5511452 16.8835 µM -0.331331642061937 0.380365207607483 no 2084 0.370196996460464 3100 870744
SGTC_2324 6149169 200 µM -0.331517072279236 0.380299854323296 no 2085 0.370126973791115 3049 2888231
SGTC_1775 st081588 35.1725 µM -0.331951129414868 0.380146887984794 no 2086 0.369963080774486 3003 1426443 YGL099W LSG1
SGTC_1324 1418-0026 34.4 µM -0.333671370124639 0.379540841481793 no 2087 0.369313777955734 3101 1372513
SGTC_2425 5628681 7.85 µM -0.334316583070902 0.379313607029212 no 2088 0.369070339083066 3069 5714958
SGTC_81 0411-0046 9.971 µM -0.334336061366001 0.379306747709768 no 2089 0.369062990737493 3040 12925265
SGTC_1077 5-fluorocytosine 377 nM -0.335843991649745 0.378775842613697 no 2090 0.368494257193438 3062 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3100 9120536 49.47 µM -0.336218254670535 0.378644109206935 no 2091 0.368353144076274 3009 16421196
SGTC_3325 9138760 55.175 µM -0.337143092658562 0.378318644466255 no 2092 0.368004516905961 3016 43844959
SGTC_1713 st033146 12.748 µM -0.337169166974064 0.378309469762766 no 2093 0.367994689499224 3151 674619
SGTC_2000 st075254 36.4 µM -0.338629693778119 0.377795667584038 no 2094 0.367444355233294 2999 17234175
SGTC_3106 9121286 49.47 µM -0.33882255119707 0.377727837950858 no 2095 0.367371705848175 3205 15943471
SGTC_564 3555-0129 330 µM -0.338932390091146 0.377689208340565 no 2096 0.367330331660958 3020 563260
SGTC_3185 9108267 49.47 µM -0.339589049820993 0.377458291000396 no 2097 0.367083012784412 3075 4910486
SGTC_1072 oxiconazole 14.9 nM -0.339677389347062 0.377427229350447 no 2098 0.367049745523889 3035 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_552 k242-0005 476 µM -0.341444340923921 0.376806106500193 no 2099 0.366384549634257 3131 4088318
SGTC_2786 7743617 45.45 µM -0.343923967355203 0.375935000332195 no 2100 0.365451733398162 3039 583674
SGTC_1615 st002656 86.5 µM -0.344541116444748 0.375718290546569 no 2101 0.365219690081895 3023 1584458
SGTC_2362 9071156 126 µM -0.344923933237593 0.375583885437398 no 2102 0.3650757786964 3158 653133
SGTC_221 trifluoperazine 10.304 µM -0.346521260903434 0.375023234579338 no 2103 0.364475504455383 3043 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2715 st079500 56.4 µM -0.346752488364233 0.374942097199343 no 2104 0.3643886368825 2978 28246688
SGTC_2359 9039622 200 µM -0.348024300316568 0.374495919260686 no 2105 0.363910966959632 2985 6463596
SGTC_1493 4348-0038 111 µM -0.348433911919297 0.374352254776272 no 2106 0.363757169105326 3093 800424
SGTC_763 3453-1109 128 µM -0.349668618579519 0.373919307483533 no 2107 0.363293703712706 3173 1560353
SGTC_288 1315-0019 35.1 µM -0.350905905106324 0.373485615070629 no 2108 0.362829470609396 3114 6811474
SGTC_1010 4112-3296 15.2 µM -0.351426234271024 0.373303277637973 no 2109 0.362634301917155 3183 704384
SGTC_3028 9087778 49.47 µM -0.353099734599323 0.372717030315207 no 2110 0.362006835923406 3032 17217395
SGTC_532 1548-0774 215 µM -0.354051873489457 0.372383616038917 no 2111 0.361650004157664 3243 5932993
SGTC_1996 st072960 66.8 µM -0.354073679079842 0.372375981407433 no 2112 0.36164183351458 3148 1719405
SGTC_1122 capsaicin 818.572 nM -0.354105683039986 0.372364776186348 no 2113 0.361629841615259 3154 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.35432768158481 0.372287053068303 no 2114 0.361546662394762 3094 6708739 YPR165W RHO1
SGTC_2724 maprotiline 69.64 µM -0.354721790483742 0.372149085825103 no 2115 0.361399012361828 3160 4011 A tricyclic antidepressant.
SGTC_1927 st060202 13.8 µM -0.356001537104567 0.371701193171069 no 2116 0.360919707027286 3125 688887
SGTC_462 ag-879 158 µM -0.356593843111266 0.371493953440363 no 2117 0.36069794367412 3135 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1832 st054113 55 µM -0.356938574748377 0.371373353721132 no 2118 0.360568895387468 3162 1251267
SGTC_2697 mebhydrolin 72.4 µM -0.357433014854716 0.37120040255618 no 2119 0.360383832326704 3205 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2437 5741531 144.16 µM -0.358554641389897 0.370808163098557 no 2120 0.359964142133049 3217 2262990
SGTC_2143 5623677 140.463 µM -0.359939965641588 0.370323892274664 no 2121 0.359446014507866 3098 5375313
SGTC_2925 9010536 32.5 µM -0.360718124320553 0.370051959712745 no 2122 0.359155087211458 3079 2994177
SGTC_237 nikkomycin 200 µM -0.361870656864182 0.369649319164831 no 2123 0.358724344216765 3176 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2248 tofa 1.1 µM -0.361886260764125 0.369643868877061 no 2124 0.358718513707572 2979 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2306 7482397 179.52 µM -0.362135189237341 0.369556924168166 no 2125 0.358625504250114 3207 891448
SGTC_906 1165-0455 526 µM -0.362647105535029 0.36937814512424 no 2126 0.358434258564025 3034 3252859
SGTC_721 1187-1332 279 µM -0.364357996327002 0.368780847455499 no 2127 0.35779534846555 2972 25730
SGTC_44 0929-0055 61.211 µM -0.364433057576212 0.36875464969064 no 2128 0.357767326915663 3017 1379590
SGTC_3009 9080819 71.4286 µM -0.365112380361796 0.368517581218858 no 2129 0.357513759866893 3116 17027216
SGTC_519 k048-0011 62.8 µM -0.366577333432323 0.368006515740296 no 2130 0.356967159116215 3130 6836379
SGTC_2718 lomofungin 53.02 µM -0.368074891302598 0.367484317093308 no 2131 0.35640869625251 3199 5351222 A RNA synthesis inhibitor.
SGTC_3294 9122953 26.2835 µM -0.36847446567273 0.367345026808952 no 2132 0.356259740656594 3043 16459826
SGTC_675 1309-0189 238 µM -0.368832980322614 0.367220064660069 no 2133 0.356126110200216 3098 4246530
SGTC_646 4092-0839 27.3 µM -0.369403541768554 0.367021221499779 no 2134 0.355913479219424 3202 877796
SGTC_1602 st001878 87.6 µM -0.369983064412453 0.366819291834395 no 2135 0.355697554543898 3204 595405 YLR310C CDC25
SGTC_76 0433-0009 400.328 µM -0.37055374570842 0.366620478868415 no 2136 0.355484969309211 3135 2841569
SGTC_2829 7992743 58.44 µM -0.373044660497235 0.365753117836364 no 2137 0.35455760245817 3201 16462845
SGTC_2611 pyromycin 23.93 µM -0.374288411045753 0.365320288090818 no 2138 0.354094876590231 3075 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_783 0848-0141 92.7 µM -0.377173552562502 0.364316909365473 no 2139 0.353022316675364 3049 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2763 lisinopril 49.32 µM -0.378585052935465 0.363826363524773 no 2140 0.352498011702744 3112 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1751 st044839 27.194 µM -0.379632355274217 0.363462533394241 no 2141 0.352109169870974 3120 5291326
SGTC_1369 1866-0067 208 µM -0.381140581364725 0.362938795936885 no 2142 0.351549468196397 3216 3531355
SGTC_187 1488-2104 32.728 µM -0.381243412688107 0.362903096674666 no 2143 0.351511319262745 3144 2852859
SGTC_1725 st036284 20.55 µM -0.381660468420155 0.362758322445174 no 2144 0.351356612954815 3271 707914
SGTC_2792 7535235 81.82 µM -0.382516900806966 0.362461087155686 no 2145 0.351038997645092 3127 1281891
SGTC_1172 0370-0043 85 µM -0.385372189228562 0.361470724241762 no 2146 0.349980842109515 3214 376585
SGTC_215 1287-0124 461.5 µM -0.385806259596784 0.361320247054729 no 2147 0.349820079533274 3112 5560863
SGTC_970 1315-0089 19.5 µM -0.386125629287444 0.361209546323362 no 2148 0.349701814760877 3154 6811083 YLR033W RSC58
SGTC_534 k292-0788 63.4 µM -0.386163942496808 0.361196266882188 no 2149 0.349687628097881 3250 4146317
SGTC_1076 itraconazole 331 nM -0.386446009080079 0.361098507144346 no 2150 0.349583190593242 3138 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2040 5100729 123 µM -0.38832625530732 0.360447076130671 no 2151 0.348887304941701 3073 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1561 5-methoxyflavone 52.9 µM -0.389951506885938 0.359884316815123 no 2152 0.348286202880311 3126 94525
SGTC_1009 4106-0057 9.87 µM -0.391362350152897 0.359396044586116 no 2153 0.347764708840786 3234 2928005
SGTC_634 1611-4317 11.2 µM -0.39230369898959 0.359070385112204 no 2154 0.347416915430339 3219 2843522
SGTC_2524 avocatin b 10.57 µM -0.393252051638921 0.358742406195622 no 2155 0.347066664223283 3164 6710748
SGTC_1934 st074720 32.6 µM -0.394593568872336 0.358278632857046 no 2156 0.346571430247428 3057 17250992
SGTC_460 trequinsin 123 µM -0.394761243920602 0.358220680919115 no 2157 0.346509549802981 3184 5537 A vasodilator.
SGTC_645 0845-0943 5.41 µM -0.394912202068594 0.35816850947879 no 2158 0.346453842231002 3146 1885106
SGTC_2260 7964312 200 µM -0.395589752202177 0.357934379415372 no 2159 0.346203849127593 3246 231951
SGTC_1910 st062352 60.4 µM -0.397068583271194 0.35742354930393 no 2160 0.345658443263731 3023 2245730
SGTC_2690 usnic acid 100 µM -0.397107658969216 0.357410054910761 no 2161 0.345644036140998 3343 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3203 9113543 49.47 µM -0.397161699841011 0.357391392741491 no 2162 0.345624111760445 3234 17018012
SGTC_3224 9130643 49.47 µM -0.399289911384331 0.356656719791049 no 2163 0.344839799943596 3288 17644395
SGTC_591 4299-0174 154 µM -0.403766823929687 0.35511299711137 no 2164 0.343192097438949 3147 5509088
SGTC_280 3448-3607 3.04 µM -0.403835559251949 0.355089314343422 no 2165 0.34316682291361 3221 626179
SGTC_3307 9126885 69.2785 µM -0.40417280835866 0.354973123214561 no 2166 0.343042823898997 3099 24824909
SGTC_1667 st014849 34.6 µM -0.404616064086932 0.354820430547129 no 2167 0.342879874307536 3149 5348460
SGTC_846 0335-0850 148 µM -0.404668497398837 0.354802369869543 no 2168 0.342860600715094 3187 6819598
SGTC_2620 irigenin 100 µM -0.405929508319476 0.354368112479868 no 2169 0.342397197862954 3282 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3327 9140648 26.9345 µM -0.40615984203964 0.354288812324672 no 2170 0.342312579225742 3244 8029710
SGTC_2858 9025781 8.96 µM -0.406189186217106 0.354278710055052 no 2171 0.342301799504108 3198 4894980 YPL153C RAD53
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.406886045445959 0.354038833670308 no 2172 0.342045842761373 3168 97141
SGTC_1402 3909-7673 35.9 µM -0.407029912157625 0.353989318357632 no 2173 0.341993009479781 3110 5328014
SGTC_2807 7945238 51.95 µM -0.407381637902991 0.353868273579548 no 2174 0.341863855552169 3182 17148797
SGTC_912 3474-0017 2.18 µM -0.40916637745181 0.353254291613149 no 2175 0.341208783458619 3270 3360550
SGTC_914 3820-6779 408 µM -0.411142465724239 0.352574927661424 no 2176 0.340484036510914 3079 2893481
SGTC_177 1327-0068 8.361 µM -0.4115657836029 0.352429455277303 no 2177 0.340328857596827 3231 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1842 st055362 61.2 µM -0.413932953636178 0.351616380132257 no 2178 0.339461604640837 3118 676032
SGTC_226 1,3-diallylurea 8.28947 mM -0.415885814912736 0.350946122106553 no 2179 0.338746779943507 3207 74537 YKL182W FAS1
SGTC_1273 0849-0096 14.1 µM -0.415951341197759 0.350923640302527 no 2180 0.3387228047739 3181 5286025
SGTC_1261 0712-0010 12.7 µM -0.416392815074839 0.350772186002552 no 2181 0.338561292569233 3307 2840123
SGTC_1571 st070080 73.4 µM -0.418152777178504 0.350168640235472 no 2182 0.337917709812535 3303 4315245
SGTC_2537 larixol 68.93 µM -0.418901859742636 0.349911871176502 no 2183 0.337643928926822 3238 6708759
SGTC_2416 tofa 880 nM -0.418911228891533 0.349908660072194 no 2184 0.337640505156491 3118 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_114 0364-0001 490.298 µM -0.419809788533161 0.349600745113186 no 2185 0.337312206771869 3200 4003655
SGTC_371 0195-0006 7.36 µM -0.420908124780404 0.349224505843516 no 2186 0.336911086059449 3108 3928593
SGTC_1895 st058434 18.3 µM -0.422904509422471 0.348541016200004 no 2187 0.336182466299357 3298 5393175
SGTC_764 1951-2361 146 µM -0.424259262882254 0.348077477512467 no 2188 0.335688372505553 3151 5438930
SGTC_1441 4106-0040 13 µM -0.428874343230842 0.346500101050176 no 2189 0.334007336286719 3207 2904180
SGTC_515 4092-1064 102 µM -0.429121600755743 0.346415666316203 no 2190 0.333917366650402 3358 717353
SGTC_2172 5754775 163.918 µM -0.429665177954942 0.346230069695025 no 2191 0.333719608691592 3132 2263357
SGTC_3205 9113483 49.47 µM -0.429917698530243 0.346143862732 no 2192 0.333627755288991 3304 17018033
SGTC_3092 9117248 49.47 µM -0.430012839095508 0.346111385152201 no 2193 0.333593150854696 3222 17141857
SGTC_1803 st050068 52.4 µM -0.431040088371115 0.345760791188215 no 2194 0.333219610958655 3275 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1717 st033143 58.0435 µM -0.432056059352572 0.345414176483736 no 2195 0.332850334849346 3316 674616
SGTC_503 tyrphostin 8 294 µM -0.432762447643913 0.345173257208608 no 2196 0.3325936785989 3232 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_471 1-acyl-paf 4 µM -0.43373166378272 0.344842800534071 no 2197 0.332241655227351 3161 16759367
SGTC_1539 benzyladenosine 56 µM -0.435751554959111 0.344154494070323 no 2198 0.331508498048373 3156 92208 A nucleotide analog.
SGTC_1612 st002233 45.4 µM -0.436555604509072 0.34388064627022 no 2199 0.331216832615069 3261 1035021
SGTC_2111 5486399 200 µM -0.436843509764409 0.343782609750866 no 2200 0.331112421131645 3198 689674
SGTC_465 cgp-37157 41 µM -0.437378573945583 0.343600439418004 no 2201 0.330918410078929 3210 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_232 clozapine 119 µM -0.439762316254867 0.342789301712638 no 2202 0.330054631735859 3220 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_996 3970-0799 1.8 µM -0.441067863595559 0.342345357905581 no 2203 0.329581933912158 3218 6615648 YGL040C HEM2
SGTC_726 3448-4391 34.2 µM -0.441918816247192 0.342056113568399 no 2204 0.329273977040393 3376 1356692
SGTC_3154 9100113 49.47 µM -0.442203417491525 0.341959396424514 no 2205 0.329171006646764 3167 25237525
SGTC_3176 9106582 49.47 µM -0.443179609027557 0.341627732290412 no 2206 0.328817913335448 3211 17018027
SGTC_694 1315-0438 43.2 µM -0.443428096328711 0.341543327458075 no 2207 0.328728058623515 3191 6793154
SGTC_3011 9081274 71.4286 µM -0.444716365387403 0.341105862246492 no 2208 0.328262370512903 3186 6625322
SGTC_1359 1582-0056 520 nM -0.444757354024374 0.341091946991968 no 2209 0.328247558168553 3278 3661189
SGTC_127 0180-0333 59.125 µM -0.444857525179621 0.34105794074187 no 2210 0.328211359768779 3263 771601
SGTC_2934 9036370 36.88 µM -0.445005506716435 0.34100770611614 no 2211 0.328157887298147 3245 6462800
SGTC_831 k061-1017 217 µM -0.445880018339749 0.34071089716284 no 2212 0.327841958331363 3260 1240153
SGTC_2319 6033012 152.6 µM -0.447542712581679 0.340146851345153 no 2213 0.327241627760142 3156 847246
SGTC_3050 9093513 49.47 µM -0.447914214366969 0.340020873372345 no 2214 0.327107554717811 3226 25236664
SGTC_794 k038-0031 316 µM -0.448945053716892 0.339671404555208 no 2215 0.326735647088443 3320 6624242
SGTC_3178 9107506 49.47 µM -0.449404683143538 0.339515628208381 no 2216 0.326569876804365 3313 8897194
SGTC_2282 7944268 200 µM -0.450457097335363 0.339159050156591 no 2217 0.326190441327377 3370 2970414
SGTC_977 1348-1378 135 µM -0.450504231476316 0.339143083575439 no 2218 0.326173451875874 3161 X977
SGTC_3153 9100258 49.47 µM -0.451483393203741 0.338811460177641 no 2219 0.325820595696153 3180 25236848
SGTC_611 3453-1652 23.7 µM -0.451600629583641 0.338771762819738 no 2220 0.325778358189482 3306 1560575
SGTC_3199 9111318 49.47 µM -0.452647416956124 0.338417390042647 no 2221 0.325401324527749 3255 8548020
SGTC_1557 sumaresinolic acid 42.3 µM -0.454043916440632 0.337944850695387 no 2222 0.324898609094102 3187 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1756 st041558 35.5 µM -0.454151088451796 0.337908596992797 no 2223 0.324860042197011 3366 3955792
SGTC_1434 4073-0095 163 µM -0.454207656215286 0.337889462091043 no 2224 0.32483968649054 3298 24133745
SGTC_317 4495-0002 170 µM -0.455403197409226 0.337485150251236 no 2225 0.324409597700759 3233 15991618
SGTC_1907 st060210 83.7 µM -0.455977290631431 0.337291068240569 no 2226 0.324203154266696 3340 688793
SGTC_331 k048-0133 24.5 µM -0.455981623390281 0.337289603642023 no 2227 0.324201596415674 3205 6813582
SGTC_2491 paeonol 100 µM -0.456606780610402 0.337078308166461 no 2228 0.323976852314957 3238 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3217 9129673 49.47 µM -0.456824880598491 0.337004605132875 no 2229 0.323898460430387 3358 17248312
SGTC_2705 st078069 42.8 µM -0.4577648985919 0.336687014309519 no 2230 0.323560678285252 3263 1530061
SGTC_3062 9077494 49.47 µM -0.457875413489776 0.336649683820995 no 2231 0.323520975864854 3299 16459633
SGTC_2030 5175110 200 µM -0.458413538987359 0.336467935065659 no 2232 0.323327683269971 3318 2831986
SGTC_1021 4476-0760 85.3 µM -0.458443068839729 0.336457962635184 no 2233 0.32331707764086 3204 746768
SGTC_2983 9022671 12.99 µM -0.460851947994808 0.335644855891346 no 2234 0.322452414327958 3370 6405161
SGTC_269 exalamide 29 µM -0.46140060070946 0.335459767919012 no 2235 0.322255610310215 3216 3316 A derivative of salicylamide.
SGTC_2488 5268135 45.7 µM -0.463755938897093 0.334665648734568 no 2236 0.321411307206719 3317 1270356 YLR208W SEC13
SGTC_2815 7968870 71.43 µM -0.464319869280143 0.334475625067723 no 2237 0.321209295292336 3223 2977326 YHR190W ERG9
SGTC_2475 5812728 15.03 µM -0.464372328447952 0.33445795042456 no 2238 0.321190505985403 3210 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_567 1080-0542 68.4 µM -0.466912660369418 0.333602496666478 no 2239 0.320281183483227 3308 5950415
SGTC_593 1203-0218 61.7 µM -0.468173448648491 0.333178248386065 no 2240 0.319830278974951 3352 3666956
SGTC_3322 9139058 2.11 µM -0.468873616142399 0.332942738011775 no 2241 0.319579988064269 3365 4908926 YPR165W RHO1
SGTC_3064 1327-0027 10 µM -0.469335888998712 0.332787282671946 no 2242 0.319414783062078 3253 16000455 YPR107C YTH1
SGTC_1531 st059297 52.4 µM -0.469502058133141 0.332731409537384 no 2243 0.319355407036727 3319 7566702
SGTC_2519 cryptotanshinone 88.04 µM -0.470007419462663 0.332561508384619 no 2244 0.319174858367214 3361 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2395 5646831 180.19 µM -0.470353643858911 0.332445128499794 no 2245 0.319051188740958 3388 6808628
SGTC_2423 st077119 87.2 µM -0.470360919283746 0.332442683111372 no 2246 0.319048590211509 3278 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3073 9114972 49.47 µM -0.471117038345197 0.332188578119798 no 2247 0.318778579209153 3299 41905075
SGTC_1154 4088-0362 150 µM -0.471798119940391 0.331959756604716 no 2248 0.318535446495008 3262 6618304
SGTC_873 0591-4978 488 µM -0.474075767741191 0.331194995718836 no 2249 0.317722938994413 3421 3305145
SGTC_1707 st032323 6.317 µM -0.475092733037676 0.330853758479041 no 2250 0.317360438948808 3287 3132057 YMR211W DML1
SGTC_2403 6032726 181.2 µM -0.477922847937257 0.329904868876531 no 2251 0.316352559384122 3265 2881040
SGTC_979 1426-2828 121 µM -0.478743398893465 0.329629956240755 no 2252 0.316060593730978 3367 747872
SGTC_839 0122-0028 230 µM -0.478881658753702 0.329583643514896 no 2253 0.316011409861827 3239 759448
SGTC_2025 5147754 141 µM -0.479946598833454 0.329227009554104 no 2254 0.315632682611311 3278 315777 YLR208W SEC13
SGTC_3349 9149703 23.001 µM -0.48084824126755 0.328925183171372 no 2255 0.315312180575897 3305 4910494
SGTC_390 dec-rvkr-cmk 16.7 µM -0.481127112000772 0.328831853276293 no 2256 0.315213080000808 3316 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_405 ebelactone b 50 µM -0.481180159194373 0.328814101136873 no 2257 0.315194230451225 3277 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3156 9099931 49.47 µM -0.481232375238239 0.328796627517265 no 2258 0.31517567670851 3202 18111053
SGTC_1313 1220-0047 237 µM -0.481337775516232 0.328761357422219 no 2259 0.315138226619821 3297 3528706
SGTC_2405 ticlatone 3.52 µM -0.482368747411953 0.328416443755712 no 2260 0.314772009136224 3040 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1553 gossypol 38.6 µM -0.482530699542705 0.328362275630924 no 2261 0.314714497724061 3279 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2075 5212009 200 µM -0.483045992134114 0.328189949738706 no 2262 0.314531540195258 3341 780898
SGTC_2818 7996756 12.99 µM -0.483423461678899 0.328063738291915 no 2263 0.314397546405878 3196 2241621
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.484016320321877 0.327865548559397 no 2264 0.314187143354482 3403 165506
SGTC_2982 9019404 25.97 µM -0.484503710238458 0.327702652803643 no 2265 0.314014215923774 3221 22333232
SGTC_2006 4011487 200 µM -0.486174011303132 0.327144652616023 no 2266 0.313421897931101 3399 45595294
SGTC_2907 7721985 69.9 µM -0.486728542908413 0.326959484659742 no 2267 0.313225357564643 3315 3267881
SGTC_1282 0886-0010 32.4 µM -0.486768136033434 0.32694626544052 no 2268 0.313211326763615 3419 2836211 YNL267W PIK1
SGTC_1326 1431-2094 10.8 µM -0.487724183150551 0.326627129613121 no 2269 0.312872610009258 3196 616278
SGTC_2588 indole-3-carbinol 100 µM -0.487782977484886 0.326607507752633 no 2270 0.312851784988507 3373 3712 Induces cell cycle arrest.
SGTC_3137 9097352 49.47 µM -0.491239787115592 0.325454686273334 no 2271 0.31162843072406 3495 44120435
SGTC_577 r071-0003 38.6 µM -0.49133536259602 0.325422836174986 no 2272 0.311594636292838 3262 4568517 YMR134W ERG29
SGTC_1688 st021091 57.6 µM -0.492580531582501 0.325008005791923 no 2273 0.311154503431562 3379 3656366
SGTC_1291 0993-0025 5.79 µM -0.492672557443571 0.324977355803056 no 2274 0.311121985533528 3398 4353356
SGTC_1706 st031321 9.9705 µM -0.494773072541247 0.324278083973886 no 2275 0.310380157024172 3364 6103185
SGTC_2904 7225135 42.03 µM -0.495493540875632 0.324038379029569 no 2276 0.310125890145275 3389 4446116
SGTC_2736 butenafine 14.65 µM -0.496480443613586 0.323710147857637 no 2277 0.309777740856182 3270 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1494 4358-1428 177 µM -0.497121164692374 0.323497125625073 no 2278 0.309551805220208 3407 1564571
SGTC_2605 digitonin 300 nM -0.498034099487465 0.323193699699595 no 2279 0.309230003960077 3454 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_796 1234-0020 70.7 µM -0.500847084353613 0.322259507131413 no 2280 0.30823937287926 3342 46495034
SGTC_75 0159-0059 199.013 µM -0.501219101717374 0.322136043972666 no 2281 0.308108466171856 3514 5377270
SGTC_1404 3909-7820 48.3 µM -0.501728277434421 0.321967093236123 no 2282 0.307929335293056 3379 23741373
SGTC_468 gf-109203x 121 µM -0.504540327620116 0.321034684026406 no 2283 0.306940865328504 3310 2396 A protein kinase C inhibitor.
SGTC_3002 9075603 71.4286 µM -0.504587107147718 0.321019182560664 no 2284 0.306924433588064 3382 20105405
SGTC_1100 amiodarone 5.07 µM -0.504949503316662 0.320899104876817 no 2285 0.306797151734793 3390 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.505718166005116 0.320644475357778 no 2286 0.306527256856667 3312 2374 Ca(2+)-ATPase inhibitor.
SGTC_698 k064-0052 127 µM -0.50739763725401 0.320088422346276 no 2287 0.305937921601454 3408 5088751
SGTC_501 nsc-95397 161 µM -0.507881402594432 0.3199283282463 no 2288 0.305768258880189 3429 262093
SGTC_133 0724-0033 378.92 µM -0.507920021733915 0.319915549328772 no 2289 0.305754716447812 3212 280309
SGTC_137 0438-0332 85.389 µM -0.508829736834333 0.319614590104718 no 2290 0.30543578684222 3405 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1223 0764-0573 147 µM -0.50960294728906 0.319358883788153 no 2291 0.305164829316902 3350 1609797
SGTC_2810 7959871 45.46 µM -0.509625244366305 0.319351511256228 no 2292 0.305157017295067 3328 2974535
SGTC_1984 st072354 53.1 µM -0.512479717273741 0.318408270065421 no 2293 0.304157655988927 3253 5762938
SGTC_2338 7999974 200 µM -0.512621498631728 0.318361449984184 no 2294 0.304108055854605 3356 315925
SGTC_1102 cgs 12066b 26.1 µM -0.513624204702483 0.31803041186831 no 2295 0.303757376740534 3341 6438352 A 5-HT1B full agonist.
SGTC_3252 9135871 49.47 µM -0.51569034698807 0.317348744390472 no 2296 0.303035348828382 3417 17682838
SGTC_1813 st051246 8.6015 µM -0.516694565240221 0.317017653289188 no 2297 0.302684695253711 3361 5291959
SGTC_1534 6-azauridine 81.6 µM -0.51717931207944 0.316857884482075 no 2298 0.302515496118855 3320 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1603 st002045 67.8 µM -0.518037539279059 0.316575103199413 no 2299 0.302216039048666 3415 5887985
SGTC_569 4130-2812 160 µM -0.51806635544471 0.316565610285479 no 2300 0.30220598667197 3339 743552
SGTC_1160 4092-0570 10.5 µM -0.519204668033251 0.316190712506399 no 2301 0.301809012075599 3321 4994975
SGTC_2438 5259590 200 µM -0.521464995502225 0.315446844698435 no 2302 0.301021442180436 3370 1201127
SGTC_2711 st079103 59.1 µM -0.521927704546799 0.31529466042634 no 2303 0.30086033395246 3331 54693780
SGTC_1709 st033179 39.1045 µM -0.522873085753983 0.31498382347709 no 2304 0.300531287612007 3347 573381
SGTC_106 0092-0003 11.579 µM -0.523235959342157 0.31486454710417 no 2305 0.300405030174458 3338 1072148
SGTC_1652 st011932 78 µM -0.523371880204301 0.314819874952598 no 2306 0.300357744338928 3367 1551076
SGTC_2245 6637752 200 µM -0.524772881515935 0.314359575725542 no 2307 0.299870542758723 3363 681890
SGTC_2625 euphol 100 µM -0.524912643282021 0.314313672786708 no 2308 0.299821959898136 3427 6708538 A triterpene alcohol.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.524951965475342 0.314300758440012 no 2309 0.299808291676092 3349 65057 A dermal irritant. YDR527W RBA50
SGTC_860 0443-0016 25.1 µM -0.525822317820694 0.314014972176983 no 2310 0.299505833277118 3386 5337942
SGTC_885 0865-0106 16.8 µM -0.525868100739681 0.313999942121817 no 2311 0.299489926966124 3350 2793380
SGTC_3221 9128209 49.47 µM -0.526595692436959 0.313761122779196 no 2312 0.299237191972982 3343 16460723
SGTC_993 3909-8757 62.7 µM -0.527449755236728 0.313480891026603 no 2313 0.298940649725305 3300 4288324 YLR208W SEC13
SGTC_2641 levomentholum 100 µM -0.527572913281872 0.313440489764812 no 2314 0.298897898587391 3368 16666
SGTC_2427 5545055 42.75 µM -0.531615270252742 0.312115663443625 no 2315 0.29749624320184 3361 5372858
SGTC_2007 4011539 71.82 µM -0.532249947145659 0.311907876854658 no 2316 0.297276446872022 3381 45595301
SGTC_3155 9099265 49.47 µM -0.533956326378835 0.311349523001484 no 2317 0.296685875261157 3397 25236499
SGTC_1650 st011916 45.8 µM -0.534120239429172 0.311295910910886 no 2318 0.296629173848299 3442 242528
SGTC_2921 7974240 10.71 µM -0.535455124466953 0.310859450617869 no 2319 0.296167590364369 3422 2979074 YDR527W RBA50
SGTC_1733 st037357 54.9 µM -0.536281562992366 0.310589367649727 no 2320 0.295881985420528 3305 1272339 YGL099W LSG1
SGTC_3195 9113082 49.47 µM -0.536814077988212 0.310415393965687 no 2321 0.295698023140831 3424 17018038
SGTC_141 0443-0274 32.331 µM -0.537021625097876 0.310347599403956 no 2322 0.295626338291112 3521 1627241
SGTC_3262 9137218 49.47 µM -0.538750701671287 0.30978305300315 no 2323 0.295029441995999 3324 17650664
SGTC_734 2023-0417 80 µM -0.539159068416818 0.30964978597524 no 2324 0.294888550377094 3412 3935732
SGTC_2406 ethylparaben 405.7 µM -0.540764902164419 0.309125978504033 no 2325 0.294334818669295 3180 8434 A possible steroid mimic.
SGTC_588 3970-1144 52.9 µM -0.541663789634388 0.308832939302974 no 2326 0.294025069507921 3405 1888707
SGTC_1712 st032288 53.4 µM -0.543780343844732 0.308143418909034 no 2327 0.293296318305902 3453 2883011
SGTC_1337 1486-1011 40.3 µM -0.543933816844766 0.308093447525485 no 2328 0.293243508554453 3438 X1337
SGTC_1018 4259-0013 28.1 µM -0.544367333414654 0.307952312125633 no 2329 0.293094360188366 3428 6801262
SGTC_773 4358-1457 44.6 µM -0.544941565026874 0.307765409347377 no 2330 0.292896853975154 3462 1186886
SGTC_180 1486-1293 102.781 µM -0.545211735684765 0.307677490569387 no 2331 0.292803950503691 3504 4140536
SGTC_111 0083-0039 52.457 µM -0.545777085020234 0.307493550656341 no 2332 0.292609588345313 3380 759313
SGTC_2853 9015042 58.44 µM -0.548186301849345 0.30671024002077 no 2333 0.291781993417281 3327 6457456
SGTC_1190 1486-1332 13 µM -0.549101046041128 0.306413059291225 no 2334 0.291468053708785 3404 4150046
SGTC_1336 1486-0901 104 µM -0.549734260800907 0.306207415959872 no 2335 0.291250827072853 3417 5006114
SGTC_1764 st044502 93.5 µM -0.550210065238822 0.306052933492969 no 2336 0.291087650367545 3453 8407
SGTC_1212 0520-0165 585 µM -0.550854611025013 0.305843719699827 no 2337 0.29086667209369 3630 5403258
SGTC_1140 3229-1848 2.98 µM -0.551987711257038 0.305476079093007 no 2338 0.290478386356655 3456 2849525
SGTC_2097 5376186 200 µM -0.554153469113478 0.30477393277339 no 2339 0.289736909892199 3443 742755
SGTC_892 0929-0076 29 µM -0.554505923689344 0.304659733666658 no 2340 0.289616326386267 3377 5751038
SGTC_837 0091-0265 12.5 µM -0.554961809134485 0.304512050068429 no 2341 0.289460391552036 3368 759367
SGTC_947 3447-0010 211 µM -0.557055427900803 0.303834233987754 no 2342 0.288744779736031 3462 748350
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.557345487313857 0.303740379387907 no 2343 0.288645701374862 3465 5024745
SGTC_1621 st003705 32.4 µM -0.559160204853046 0.303153484680057 no 2344 0.288026194770964 3491 24207032
SGTC_1247 0448-0043 5.84 µM -0.560040234115571 0.302869058640855 no 2345 0.287725997327937 3436 3089013 YGL099W LSG1
SGTC_1654 st012436 41.8 µM -0.562024158718554 0.302228291597383 no 2346 0.287049779620713 3447 4323132
SGTC_891 0929-0073 133 µM -0.562813702709818 0.301973454390732 no 2347 0.286780874266456 3468 5603632
SGTC_1500 4488-1866 171 µM -0.563790288035187 0.301658380379762 no 2348 0.286448431073935 3537 2900003
SGTC_1425 4048-4433 7.33 µM -0.56389935484092 0.30162320152691 no 2349 0.286411314575732 3505 23734946
SGTC_1508 1080-0625 72.9 µM -0.564185332595749 0.30153096985751 no 2350 0.286314004395673 3419 767111
SGTC_2861 9024595 19.48 µM -0.564915198273436 0.301295635907449 no 2351 0.286065722825777 3362 16482810
SGTC_3152 9099253 49.47 µM -0.565176397589132 0.301211436310681 no 2352 0.285976894386084 3472 25236131
SGTC_2691 st077356 60.2 µM -0.565273199824749 0.301180234062049 no 2353 0.285943977294654 3512 2839272
SGTC_2926 9010726 65.15 µM -0.565944131391905 0.30096401283455 no 2354 0.285715880057189 3455 2994293
SGTC_293 4049-0273 38.5 µM -0.567009827200387 0.300620714822554 no 2355 0.28535375248586 3398 1380311
SGTC_2262 9014885 67.46 µM -0.569781818271295 0.299728588291427 no 2356 0.284412844375705 3431 6457424
SGTC_573 3702-0553 84.7 µM -0.570850478609691 0.2993849754533 no 2357 0.284050501003975 3480 1222756
SGTC_1390 3413-2614 145 µM -0.571185061873031 0.299277431599606 no 2358 0.283937101549111 3458 3421432
SGTC_2094 5332512 191.667 µM -0.572826902165367 0.298749955181056 no 2359 0.28338095102153 3498 755774
SGTC_1782 st039423 80.636 µM -0.57419714364735 0.298310059480089 no 2360 0.282917200999421 3380 2068169
SGTC_12 0849-0099 9.267 µM -0.574386867991265 0.298249174542699 no 2361 0.282853018664938 3442 6071388
SGTC_2231 micatex 6.853 µM -0.574487372809125 0.298216923570629 no 2362 0.282819021466269 3468 20737 An antifungal of unknown mechanism.
SGTC_321 4534-3890 65.3 µM -0.576691952505764 0.297509896287988 no 2363 0.282073784862103 3472 699746
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.577046803621526 0.297396164092265 no 2364 0.281953919319904 3482 61125 An anti-inflammatory.
SGTC_121 0557-0495 61.343 µM -0.578832638126048 0.296824093692497 no 2365 0.281351053101361 3489 3104427
SGTC_162 k030-0015 37.8 µM -0.579673866166023 0.296554791129366 no 2366 0.281067285085523 3480 1809920 YMR134W ERG29
SGTC_1258 0671-0043 57.1 µM -0.581822701517809 0.295867392580098 no 2367 0.280343055584728 3446 4298767
SGTC_1805 st050013 60.3 µM -0.582974413220037 0.295499268918544 no 2368 0.279955262487854 3429 4037144
SGTC_1145 3546-0597 10.2 µM -0.584266121563571 0.295086648663814 no 2369 0.279520640773201 3423 875334
SGTC_2352 9027995 87.8 µM -0.58451890301962 0.295005931809799 no 2370 0.279435625624028 3429 2997347
SGTC_1659 st012954 42.1 µM -0.584693008085849 0.294950343405729 no 2371 0.279377078126392 3504 24207262
SGTC_1634 st006576 41 µM -0.585872507938261 0.294573878925531 no 2372 0.278980596679019 3522 3915356
SGTC_3284 9108171 64.8615 µM -0.58834487299816 0.293785487082348 no 2373 0.278150415903993 3443 8687505
SGTC_411 enrofloxacin 100 µM -0.589467955783688 0.293427679347591 no 2374 0.277773700984296 3577 71188 A bacterial gyrase inhibitor.
SGTC_1366 1683-0113 21.9 µM -0.589586053761439 0.293390065742766 no 2375 0.277734101938512 3477 708623
SGTC_255 tunicamycin 200.472 nM -0.590285910162546 0.293167210900626 no 2376 0.277499491977516 3453 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2214 7179297 48.276 µM -0.592487563345047 0.292466652210178 no 2377 0.276762073160892 3510 769744
SGTC_2118 5526350 200 µM -0.595912940295629 0.291378258564342 no 2378 0.275616694025152 3482 743594
SGTC_2857 9024691 58.44 µM -0.597171757276174 0.290978752199777 no 2379 0.275196356637856 3498 16478292
SGTC_754 3474-0146 171 µM -0.59768482153907 0.290815996227383 no 2380 0.275025127561918 3381 24762078
SGTC_1381 2324-0066 62.1 µM -0.59793188595057 0.290737636807978 no 2381 0.27494269148818 3495 10885928
SGTC_924 2046-0044 21.3 µM -0.600451142181499 0.289939188912923 no 2382 0.274102806425347 3531 3623589
SGTC_1839 st053978 48 µM -0.601154584481599 0.289716425135502 no 2383 0.273868515112405 3557 3788398
SGTC_1088 bifonazole 369 nM -0.601791246313744 0.289514878445578 no 2384 0.273656551364226 3481 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_37 0566-0070 1.56 µM -0.602033205284272 0.289438299276486 no 2385 0.273576017282528 3505 1626686
SGTC_788 1182-0090 188 µM -0.608841397782645 0.287287440990687 no 2386 0.271314785397705 3596 5715185
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.610087160911743 0.286894697001498 no 2387 0.270902035576976 3644 6728940
SGTC_1260 0700-1617 7.75 µM -0.610258653306221 0.286840651589016 no 2388 0.27084524076993 3528 2853078
SGTC_1815 st051655 58.2 µM -0.611279625851682 0.286518994477556 no 2389 0.270507238403549 3514 5984156
SGTC_1245 0418-0076 17.2 µM -0.61130889838905 0.286509774697043 no 2390 0.270497550569132 3526 6790114
SGTC_1090 efavirenz 20.7 µM -0.611442791331742 0.286467605103067 no 2391 0.270453240506443 3547 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2877 9040724 71.43 µM -0.61210953734373 0.286257657249528 no 2392 0.270232643927364 3545 6463895
SGTC_2748 diazoxide 86.69 µM -0.612412246145189 0.286162363121447 no 2393 0.270132520764505 3468 3019 A potassium channel activatior.
SGTC_391 gliotoxin 8.33 µM -0.612747740972868 0.286056765409245 no 2394 0.270021575065978 3584 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2147 5545932 89.7195 µM -0.613077557151248 0.285952973115995 no 2395 0.269912529484848 3519 797404
SGTC_2012 4023501 200 µM -0.614080978740708 0.285637309078034 no 2396 0.26958090849839 3470 3477460
SGTC_2207 7258803 200 µM -0.614908601833386 0.285377073922327 no 2397 0.269307540908102 3521 3666799
SGTC_2479 5617353 43.85 µM -0.61723051093892 0.284647583652781 no 2398 0.268541346836485 3580 2731746
SGTC_2908 7930301 100 µM -0.618143890827676 0.284360864953676 no 2399 0.268240246188142 3464 2223178
SGTC_2211 7117706 200 µM -0.618901706077224 0.284123084291449 no 2400 0.267990557261976 3511 822771
SGTC_1820 st053765 18.6 µM -0.620149474760318 0.28373177762852 no 2401 0.267579691055465 3532 3690829
SGTC_367 0335-0881 7.1 µM -0.620397529884751 0.283654017032429 no 2402 0.26749804913561 3533 23828853
SGTC_1443 4112-3303 14 µM -0.620514789935521 0.283617261775141 no 2403 0.267459459926997 3544 704433
SGTC_1310 1188-0297 994 nM -0.620525143441869 0.283614016569869 no 2404 0.267456052817789 3524 1588352
SGTC_2766 oltipraz 83.91 µM -0.621086091208589 0.283438219576872 no 2405 0.267271490080494 3550 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1882 5615643 20 µM -0.621257227566391 0.283384597074548 no 2406 0.26721519568384 3506 2253075
SGTC_2413 inermin 26.06 µM -0.621311152487962 0.283367701677211 no 2407 0.267197458607057 3628 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_523 1934-0222 13.7 µM -0.622652869299182 0.282947479481917 no 2408 0.266756330253091 3555 1361595
SGTC_821 1114-0266 29.2 µM -0.623291211038197 0.28274765761197 no 2409 0.266546586165719 3548 3123235
SGTC_1648 st011736 69.8 µM -0.623545229240234 0.282668160458015 no 2410 0.26646314496068 3590 2855514
SGTC_551 k048-0028 34.9 µM -0.624995143563004 0.282214603210468 no 2411 0.265987122744188 3576 6836383
SGTC_992 3909-8734 162 µM -0.625455592744639 0.28207064038439 no 2412 0.265836042581334 3527 4288319
SGTC_54 0159-0055 9 µM -0.62623881845959 0.281825840364441 no 2413 0.265579154627449 3637 3319099
SGTC_2267 7931562 200 µM -0.627790466379074 0.281341169767262 no 2414 0.265070606150581 3491 934880
SGTC_1330 1469-0054 61.8 µM -0.629525172297702 0.280799796199345 no 2415 0.264502647145069 3570 7102664
SGTC_1573 oleylamine 1.06 µM -0.630168899569981 0.28059902758695 no 2416 0.264292042436317 3573 5356789 An amine of the fatty acid oleic acid.
SGTC_1347 1493-0251 600 nM -0.631906730167057 0.280057372128666 no 2417 0.263723912666729 3576 3986378
SGTC_295 k015-0027 31 µM -0.632008595929007 0.280025637845566 no 2418 0.263690630154199 3543 3887424
SGTC_64 000l-0018 272.079 µM -0.632491597345577 0.27987519194614 no 2419 0.263532848687241 3542 6811119
SGTC_2936 9038235 15.59 µM -0.632758438956616 0.279792092594268 no 2420 0.263445700539023 3573 4749415
SGTC_2799 7812892 81.82 µM -0.633709861784018 0.279495899609288 no 2421 0.263135093902646 3574 20205235
SGTC_2331 7980721 200 µM -0.634665490993736 0.27919855046751 no 2422 0.262823302487986 3543 2981221
SGTC_3078 9116413 49.47 µM -0.635501343810207 0.278938596517845 no 2423 0.262550745283545 3523 17177322
SGTC_3124 9127567 49.47 µM -0.636757328751943 0.278548201136469 no 2424 0.262141462418195 3559 17592030
SGTC_2123 5259487 200 µM -0.63767337362279 0.278263636613217 no 2425 0.261843160806855 3571 2173474
SGTC_86 0417-1630 471.922 µM -0.638473764560592 0.278015115453227 no 2426 0.261582663429934 3610 3634867
SGTC_198 3454-2873 16.191 µM -0.638616587684869 0.277970780302936 no 2427 0.261536193823825 3547 710957
SGTC_2744 captopril 92.04 µM -0.638889593567932 0.277886043426242 no 2428 0.261447379134717 3540 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_717 1532-0246 73.2 µM -0.639177801679728 0.277796601692819 no 2429 0.261353635641104 3550 9561992
SGTC_3087 9117406 49.47 µM -0.641353022957818 0.27712200310958 no 2430 0.26064667349226 3571 42546093
SGTC_292 k038-0015 474 µM -0.642034967381443 0.276910677731569 no 2431 0.260425239613777 3572 46368540
SGTC_546 peri-Naphthalide 147 µM -0.642280497771215 0.276834610500517 no 2432 0.260345537276173 3516 223824 A penicillin ester.
SGTC_2091 4-phenylthiadiazole 200 µM -0.642712668660252 0.276700745451756 no 2433 0.260205279551748 3564 270010
SGTC_3048 9093155 49.47 µM -0.642864741176307 0.276653648494358 no 2434 0.260155934855248 3569 25236002
SGTC_655 k060-0012 42 µM -0.643033661549927 0.276601338350395 no 2435 0.260101128998116 3523 5994525
SGTC_2531 methyl deoxycholate 70.07 µM -0.643366866936585 0.276498167725655 no 2436 0.259993038669814 3558 16667744 Haematoxylin.
SGTC_1215 3852-0577 11.2 µM -0.644827148152275 0.276046242464114 no 2437 0.259519603376622 3640 2884876
SGTC_3016 9080866 49.47 µM -0.645275703211547 0.275907497284049 no 2438 0.25937426753286 3582 17066299
SGTC_287 k060-0039 29.6 µM -0.645396053601782 0.27587027683281 no 2439 0.259335280087705 3611 5861974
SGTC_273 hydroxyurea 18.1 mM -0.646430481858647 0.275550463663988 no 2440 0.259000302505654 3633 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1208 2323-2347 50.3 µM -0.647328416848925 0.275272997898069 no 2441 0.258709706906204 3596 5412760
SGTC_952 1185-0122 232 µM -0.647841781655633 0.275114427781598 no 2442 0.258543644286117 3553 678600
SGTC_3013 9080133 71.4286 µM -0.64785509976865 0.275110314629817 no 2443 0.25853933689395 3664 17050193
SGTC_1548 st061468 90.8 µM -0.649157413686987 0.274708255727015 no 2444 0.258118317397797 3577 390799
SGTC_1923 st058458 19.1 µM -0.649721788796286 0.274534108172366 no 2445 0.257935973458669 3656 3534982
SGTC_1509 1326-1131 80 µM -0.650637484205605 0.274251670685437 no 2446 0.25764026369251 3544 768313
SGTC_811 0416-0114 265 µM -0.651588579783631 0.273958466352273 no 2447 0.257333308459845 3611 6612453
SGTC_1118 chelidonine 707.474 nM -0.652372106195218 0.273717036798753 no 2448 0.257080577116822 3603 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.652584781408585 0.27365152292671 no 2449 0.257011999678856 3574 521171
SGTC_1297 1068-0111 14.1 µM -0.654375368586202 0.273100246493084 no 2450 0.256434999738421 3573 767057
SGTC_708 3448-5400 146 µM -0.654710522774637 0.272997122194475 no 2451 0.256327074481697 3590 3462195
SGTC_3305 9127027 53.8275 µM -0.655867249213331 0.272641354961515 no 2452 0.255954771149189 3548 41905295
SGTC_2561 acetosyringone 100 µM -0.65669751037156 0.272386138583464 no 2453 0.255687717794376 3587 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_65 0798-0905 34.986 µM -0.658080366720718 0.271961321969404 no 2454 0.255243245478932 3728 3602145
SGTC_2768 sulfasalazine 50.2 µM -0.65867770199649 0.271777921186092 no 2455 0.255051377305665 3649 5384001 An antioxidant and salicylic acid derivative.
SGTC_2468 5987765 72.9 µM -0.658716263087808 0.271766083829246 no 2456 0.255038993812611 3621 26772094
SGTC_1512 0259-0544 12.2 µM -0.658749320974304 0.271755936032378 no 2457 0.25502837786691 3606 18476
SGTC_1252 0493-0875 34.8 µM -0.65986553352748 0.271413402404748 no 2458 0.254670062009647 3615 3960963
SGTC_234 nsc-17383 10.7 µM -0.660130972886713 0.271331978346632 no 2459 0.254584892029124 3643 408974
SGTC_2581 avocatin a 64 µM -0.660597852913051 0.271188791500866 no 2460 0.2544351231643 3609 6710728 A skin care supplement.
SGTC_158 k038-0087 26.446 µM -0.660689891386122 0.27116056878385 no 2461 0.254405603902907 3572 X158
SGTC_2642 cholecalciferol 100 µM -0.661668401754099 0.270860608525595 no 2462 0.254091879816165 3600 9821465 A vitamin D precursor, similar to steriods.
SGTC_2450 5739737 12.93 µM -0.662288139820627 0.270670714843547 no 2463 0.253893288155973 3619 2262825
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.662876803029539 0.270490404381921 no 2464 0.253704729729886 3614 4174840
SGTC_156 3474-0145 5.642 µM -0.663049370520688 0.270437557481295 no 2465 0.253649467490021 3574 2265471
SGTC_2309 7664088 163.95 µM -0.66537481537527 0.269725919149973 no 2466 0.252905394508328 3633 704922
SGTC_729 4092-0585 94.1 µM -0.665470624476493 0.269696619543007 no 2467 0.2528747631137 3604 2169061
SGTC_110 0850-0284 111.64 µM -0.666700751660814 0.269320573141897 no 2468 0.252481649287236 3504 3906265
SGTC_2702 st077768 96.8 µM -0.667527225112 0.269068070300065 no 2469 0.252217712743658 3562 6484119
SGTC_1768 st044301 37.178 µM -0.667644041329166 0.269032390382239 no 2470 0.2521804189067 3629 3931349
SGTC_1492 4158-0558 28.5 µM -0.667725159445041 0.269007615358939 no 2471 0.252154523478985 3613 3967268
SGTC_152 4469-0003 551.229 µM -0.667728385060416 0.269006630218015 no 2472 0.252153493791141 3610 697280
SGTC_233 rapamycin 362 pM -0.669748335201977 0.268390069516737 no 2473 0.251509116775156 3638 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1407 3909-7909 12.3 µM -0.670183307757884 0.26825739346029 no 2474 0.251370471693172 3641 4411780
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.672331879487039 0.267602516935503 no 2475 0.2506862194878 3666 688788
SGTC_21 0849-0113 22.993 µM -0.673317915141071 0.26730224702916 no 2476 0.25037252884457 3606 1560156
SGTC_2781 5567276 71.43 µM -0.674490759476595 0.266945311200593 no 2477 0.249999679274407 3636 2853274
SGTC_1524 corynanthine 62.1 µM -0.676794032170115 0.266245049491582 no 2478 0.249268322558702 3672 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2159 5658611 73.75 µM -0.676828057668848 0.266234711726851 no 2479 0.249257526997198 3655 793844
SGTC_2741 miltefosine 3.04 µM -0.676917762774812 0.266207458132526 no 2480 0.249229066681411 3566 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2035 5154463 94.595 µM -0.677538363544569 0.26601895012605 no 2481 0.249032218943537 3631 2769623
SGTC_399 oxolinic acid 75 µM -0.677569050591127 0.266009630664481 no 2482 0.249022487496706 3616 4628 A DNA gyrase inhibitor.
SGTC_103 0844-0104 51.839 µM -0.678195065537239 0.26581954999915 no 2483 0.248824010409844 3683 5375804
SGTC_1046 2001-0062 216 µM -0.678709885795534 0.265663283644296 no 2484 0.248660850557953 3593 739778
SGTC_607 4491-0986 66.8 µM -0.679673559726011 0.265370899411367 no 2485 0.248355590598758 3660 698981 YDR232W HEM1
SGTC_438 sphingosine 6.67 µM -0.680105081531987 0.26524002616448 no 2486 0.248218963574437 3540 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_677 0929-0063 136 µM -0.68123754633415 0.264896724709226 no 2487 0.247860596970272 3606 1539583
SGTC_2726 cimetidine 79.27 µM -0.681967903021174 0.264675440315414 no 2488 0.247629623387214 3650 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2734 clemastine 41.6 µM -0.682537575709783 0.264502905449654 no 2489 0.247449545579105 3635 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3326 9140064 16.379 µM -0.684179709551807 0.264005878318754 no 2490 0.246930846613082 3632 1868434
SGTC_1477 0139-0234 16 µM -0.685485854713942 0.263610885511458 no 2491 0.246518691851738 3659 620880
SGTC_3129 9127257 49.47 µM -0.685703833874053 0.263544995562569 no 2492 0.246449944323508 3580 837894
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.688938106422383 0.262568339869521 no 2493 0.245431108921384 3690 4213774
SGTC_1491 4138-0063 26.5 µM -0.689074670293987 0.262527142370694 no 2494 0.245388139488755 3629 23883227
SGTC_2870 9038528 12.99 µM -0.690229751013039 0.262178819230437 no 2495 0.245024858409026 3644 6463316
SGTC_2391 6285546 200 µM -0.690705687776349 0.262035365895279 no 2496 0.244875257129077 3650 846083
SGTC_510 ag-490 170 µM -0.690947182860383 0.261962591625629 no 2497 0.244799366743771 3759 5328779
SGTC_2386 9075165 157.42 µM -0.69134603818225 0.261842419722036 no 2498 0.244674053269273 3641 16452277
SGTC_1958 st076513 41.9 µM -0.69141113299154 0.261822809863201 no 2499 0.244653604880229 3639 732122 YGL099W LSG1
SGTC_1257 0669-0121 16 µM -0.692270010140956 0.26156414305242 no 2500 0.244383889930792 3689 4307855
SGTC_2467 5474540 200 µM -0.693408889818153 0.261221350687947 no 2501 0.244026492467206 3653 5413519
SGTC_3107 9121808 49.47 µM -0.694403477913279 0.260922177704271 no 2502 0.243714606626362 3607 662681
SGTC_1231 0242-0792 125 µM -0.694533673322209 0.260883027856938 no 2503 0.243673795504756 3663 3707635
SGTC_2103 5378138 10 µM -0.696792941899425 0.260204145716629 no 2504 0.242966191911935 3711 244142
SGTC_2946 9065502 71.43 µM -0.698477519619512 0.259698544223746 no 2505 0.242439305942335 3504 16489101
SGTC_1136 pergolide 1.05886 µM -0.699027939186718 0.25953345377512 no 2506 0.242267285278396 3663 47811 A dopamine receptor agonist.
SGTC_799 1310-0557 151 µM -0.699320893869648 0.259445608326193 no 2507 0.242175756177537 3691 5354492
SGTC_642 0335-0876 158 µM -0.699921417363429 0.259265583253288 no 2508 0.241988190635308 3694 6812350
SGTC_2541 muurolladie-3-one 83.07 µM -0.701636696427788 0.258751732259838 no 2509 0.241452880202304 3707 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1692 fluoroquinolonic acid 71 µM -0.701961585478877 0.258654463737371 no 2510 0.241351560165313 3684 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1941 st076221 61.8 µM -0.70453271439783 0.257885361760176 no 2511 0.240550542180202 3669 2828568
SGTC_942 3253-1115 227 µM -0.705533461571223 0.257586329319882 no 2512 0.240239157895474 3718 46497897
SGTC_1277 0873-0036 22 µM -0.707480820209717 0.257004957232753 no 2513 0.239633863825166 3712 5965735
SGTC_320 4092-0846 5.34 µM -0.708712917660504 0.256637474894992 no 2514 0.239251323494259 3666 1359356
SGTC_815 1582-0027 36.9 µM -0.708717037900133 0.256636246461719 no 2515 0.239250044806542 3718 3128206
SGTC_1728 st035614 33.7865 µM -0.708990340305341 0.256554769260691 no 2516 0.239165235644281 3699 15945546
SGTC_2557 derrustone 83.84 µM -0.710027777350211 0.256245610122954 no 2517 0.238843455521798 3690 629853 An antioxidant.
SGTC_183 3914-0051 30.55 µM -0.710429029501696 0.256126087968994 no 2518 0.238719063342949 3683 1596232
SGTC_695 3505-6186 243 µM -0.71064499431709 0.256061769934178 no 2519 0.238652126766834 3691 1819379
SGTC_2948 9070189 9.45 µM -0.711653398322199 0.255761561430594 no 2520 0.238339715955974 3603 6473636 YDL196W YDL196W
SGTC_1779 st039427 55 µM -0.711901196157038 0.255687818519711 no 2521 0.23826298070205 3729 1124498
SGTC_1644 st010134 20.9 µM -0.712484198821023 0.255514364783038 no 2522 0.238082496365404 3684 3818134
SGTC_1953 st076800 12.1 µM -0.71264464636429 0.255466639553789 no 2523 0.23803283861426 3699 297591
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.712737754475715 0.255438946619467 no 2524 0.238004024700145 3683 75037 A free radical scavenger.
SGTC_1412 3909-8563 178 µM -0.71357788586441 0.25518913919925 no 2525 0.237744118003168 3767 23767530
SGTC_1630 st005209 31.3 µM -0.713624717379007 0.255175217923202 no 2526 0.237729634584962 3682 3367314
SGTC_2122 5258151 111.688 µM -0.714171276809696 0.255012775401376 no 2527 0.237560637860121 3700 2173356
SGTC_3042 9091578 49.47 µM -0.715229616661452 0.254698380876629 no 2528 0.237233585637137 3652 25236497
SGTC_827 3253-0474 693 µM -0.71727831589316 0.254090363587092 no 2529 0.236601192116793 3698 5402065
SGTC_1186 1319-0216 26 µM -0.717385696856617 0.254058515850088 no 2530 0.236568071306975 3760 4565136
SGTC_1507 4075-3230 155 µM -0.717548097953083 0.254010353866823 no 2531 0.236517984818972 3626 659771
SGTC_3212 9128307 49.47 µM -0.718507553792306 0.253725913567283 no 2532 0.236222195997581 3685 27243542
SGTC_2667 digitoxin 100 µM -0.718518787617111 0.253722584178216 no 2533 0.236218733950079 3675 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3222 9128301 49.47 µM -0.719005690314287 0.253578301989335 no 2534 0.23606870681375 3746 4911358
SGTC_3310 9130229 44.1445 µM -0.719997491384303 0.253284538384372 no 2535 0.235763270060453 3760 7761258
SGTC_3182 9108849 49.47 µM -0.720158469532006 0.253236874817628 no 2536 0.235713715517315 3727 17133045
SGTC_2263 7948595 193.29 µM -0.721022206294238 0.252981213995285 no 2537 0.235447926112672 3699 2971371
SGTC_142 0335-0849 62.6745 µM -0.721797428991142 0.252751868504056 no 2538 0.235209515194651 3722 3889043 YPR107C YTH1
SGTC_520 3584-0023 682 µM -0.721895066810279 0.252722990641797 no 2539 0.235179497249536 3723 1340790
SGTC_1874 staurosporine 7.6 µM -0.721971588667196 0.252700359359349 no 2540 0.235155972712322 3736 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2102 5377816 72.7585 µM -0.722856991207352 0.252438579850963 no 2541 0.234883874619338 3721 1379702
SGTC_2525 harmine 47.85 µM -0.723260680213133 0.252319271977586 no 2542 0.234759872430489 3705 5280953 A monoamine oxidase inhibitor
SGTC_1510 1123-0200 71.5 µM -0.723998622310356 0.252101254462161 no 2543 0.23453329043682 3753 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2195 6536160 144.242 µM -0.724920906352894 0.251828914759986 no 2544 0.234250277184886 3644 3834386
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.725154285959121 0.251760025120786 no 2545 0.234178692006489 3691 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1129 3453-1384 223 µM -0.727295675476975 0.25112838864467 no 2546 0.233522423364787 3824 1084452
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.728159692516244 0.250873770793188 no 2547 0.233257918365737 3741 676296 Flavone; oxidizing agent.
SGTC_3089 9117425 49.47 µM -0.728240083642678 0.250850087220506 no 2548 0.233233316365981 3654 9401657
SGTC_1872 amphotericin b 148 nM -0.728355753399479 0.250816012487886 no 2549 0.233197920616412 3730 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1111 tnp00062 510.699 nM -0.730365681151925 0.250224306641211 no 2550 0.232583345036004 3785 676306
SGTC_1472 k841-0093 193 µM -0.730435048621015 0.250203898664013 no 2551 0.232562150633103 3799 X1472
SGTC_2680 butyl paraben 22.24 µM -0.731203070467327 0.249978004888513 no 2552 0.232327562492141 3777 7184 An antifungal and steroid mimetic.
SGTC_944 3370-0224 231 µM -0.734433038261971 0.249029179242117 no 2553 0.231342428602397 3753 4580514
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.734655741618618 0.248963829260039 no 2554 0.231274590475392 3695 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1230 0170-0365 3.77 µM -0.734923598746411 0.248885241464617 no 2555 0.231193012667014 3815 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2747 doxorubicin 7.63 µM -0.734951837238625 0.248876957217113 no 2556 0.231184413367385 3624 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1809 st050081 57.6 µM -0.73603201008912 0.248560180147294 no 2557 0.230855608780437 3776 5036894
SGTC_179 1273-0063 6.77 µM -0.738004190022048 0.247982363062072 no 2558 0.230255951479018 3729 3108139
SGTC_2304 7443016 91.4 µM -0.738417529324623 0.247861352194104 no 2559 0.230130382826825 3685 939854
SGTC_1453 4237-0541 195 µM -0.738483303242218 0.247842098866256 no 2560 0.230110404853585 3670 739892
SGTC_2911 7942208 15.64 µM -0.739405175251122 0.247572332708677 no 2561 0.229830500331824 3735 1243384
SGTC_1478 0453-0656 35.7 µM -0.739535629185116 0.247534170823915 no 2562 0.229790906497912 3767 5258496
SGTC_2974 9094440 9.66 µM -0.739700842582288 0.247485845212159 no 2563 0.229740768365061 3818 25236134
SGTC_107 0358-0022 2.6945 µM -0.739877441225603 0.247434194943003 no 2564 0.22968718186966 3753 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_134 0269-0018 6.916 µM -0.740564440310402 0.247233321322666 no 2565 0.229478787790741 3679 4378915
SGTC_2445 5742597 35.57 µM -0.740773495968193 0.247172212252229 no 2566 0.229415393948732 3701 1774255
SGTC_554 4483-2211 187 µM -0.742618475575937 0.246633256565698 no 2567 0.228856349805064 3763 747107
SGTC_1134 3477-0009 42.5 µM -0.743173452517336 0.246471259857995 no 2568 0.228688336895314 3764 3973534
SGTC_1057 3448-5381 134 µM -0.743479207492085 0.246382034930271 no 2569 0.228595802677938 3771 5497911
SGTC_2072 5231554 129 µM -0.74360752574147 0.246344594461845 no 2570 0.228556974485231 3799 789545
SGTC_1371 2421-0008 32.7 µM -0.74377968083188 0.246294368149455 no 2571 0.228504887394602 3730 2827552
SGTC_2506 ethyl hematommate 54.16 µM -0.744673026403456 0.246033822424755 no 2572 0.228234704665777 3815 3940691 An allergen.
SGTC_3095 9117207 49.47 µM -0.746575198830311 0.245479543640361 no 2573 0.227660011866593 3733 17015229
SGTC_2478 5763493 32.33 µM -0.747436336491192 0.245228835376927 no 2574 0.227400109246903 3709 1365576 YLR208W SEC13
SGTC_135 0933-0004 26.348 µM -0.750015669413202 0.244478722875709 no 2575 0.22662263375774 3753 21230617 YGL099W LSG1
SGTC_1316 1272-0050 65.9 µM -0.750870371551179 0.244230434367409 no 2576 0.226365336484509 3750 7340392
SGTC_2808 7946468 45.46 µM -0.753370968965381 0.243504799364228 no 2577 0.225613511509912 3781 2970879
SGTC_2364 9055074 200 µM -0.754449133385539 0.243192292280225 no 2578 0.22528978905552 3772 6470630
SGTC_965 1291-5240 308 µM -0.754870544939415 0.243070204664256 no 2579 0.225163330371534 3737 2834598
SGTC_1912 st060209 90.8 µM -0.755109824342208 0.24300089751544 no 2580 0.225091544455967 3778 688787
SGTC_1622 st003707 19.4 µM -0.758248812347149 0.242092682039951 no 2581 0.224151022276177 3825 10140899
SGTC_3230 9131665 49.47 µM -0.758592886626417 0.241993241760898 no 2582 0.224048064606021 3699 15943720
SGTC_163 TUB2.036 7.546 µM -0.761019475325842 0.241292567268075 no 2583 0.22332271745488 3814 15992207 YJR013W GPI14
SGTC_3008 9078912 71.4286 µM -0.765586003972291 0.239976982544893 no 2584 0.221961337458811 3766 16648731
SGTC_3214 9129694 49.47 µM -0.766862941837991 0.239609806784965 no 2585 0.221581504465173 3743 17158655
SGTC_1124 fisetin 1.16336 µM -0.767614929283408 0.239393720894542 no 2586 0.221357995104838 3793 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_986 1493-0483 84 µM -0.767990980293196 0.239285701420367 no 2587 0.221246271771831 3705 40079
SGTC_1859 st055998 20 µM -0.768500258890486 0.239139455198398 no 2588 0.221095018458108 3756 676301
SGTC_3341 9147222 25.867 µM -0.768518575400419 0.239134196275596 no 2589 0.221089579644556 3789 1939759
SGTC_2121 5257820 149.641 µM -0.772090287589164 0.238109917211936 no 2590 0.220030477116797 3863 791256
SGTC_640 3381-0960 37.1 µM -0.772415225822549 0.238016852395996 no 2591 0.219934269414681 3823 1745025
SGTC_42 0133-0086 60.653 µM -0.773059795258223 0.237832301757254 no 2592 0.21974349676905 3704 162923 Model of phenazepam hydroxylation.
SGTC_1174 0739-0097 51.1 µM -0.773506034262295 0.237704582308737 no 2593 0.219611479475943 3803 728447
SGTC_749 1000-0129 128 µM -0.774172389928864 0.237513932653281 no 2594 0.219414426726185 3829 708470
SGTC_1891 st059073 26.2 µM -0.775187073312814 0.23722378494159 no 2595 0.219114562734092 3804 688754
SGTC_3167 9103034 49.47 µM -0.77552769686775 0.23712642763939 no 2596 0.219013952915766 3815 5127859
SGTC_705 1124-0212 310 µM -0.775597821430239 0.23710638730508 no 2597 0.218993243555293 3749 9554485
SGTC_3032 9089427 49.47 µM -0.777189674226699 0.236651714934035 no 2598 0.218523436684703 3776 17173707
SGTC_824 1304-0008 100 µM -0.778934363063105 0.236153940239589 no 2599 0.218009190213848 3821 768245
SGTC_1184 1269-1718 139 µM -0.779501282791812 0.235992317414344 no 2600 0.217842241113853 3852 5403821
SGTC_2442 5158906 48.48 µM -0.779644194152283 0.235951584517188 no 2601 0.217800167566243 3824 1893835
SGTC_960 1222-0186 7.7 µM -0.780375404451903 0.235743234059682 no 2602 0.217584970343976 3839 3126296
SGTC_3263 9137018 49.47 µM -0.78105464579629 0.235549782519509 no 2603 0.21738517771183 3795 43844957
SGTC_3026 9090633 49.47 µM -0.781581118965478 0.235399900436472 no 2604 0.217230393337475 3820 25236842
SGTC_2992 9074591 71.4286 µM -0.783463340715894 0.23486447989874 no 2605 0.216677536530362 3781 17741321
SGTC_2388 9080168 200 µM -0.784064832079727 0.234693520492008 no 2606 0.216501034819956 3781 15943073
SGTC_2760 etidronate 98.04 µM -0.784142854687484 0.234671349491129 no 2607 0.216478145952025 3810 3305 A chelator and antioxidant.
SGTC_2053 5265679 138 µM -0.784770085342871 0.234493156937001 no 2608 0.216294191197467 3774 764595
SGTC_2019 4016004 108 µM -0.785458287687107 0.234297728836718 no 2609 0.216092458767345 3838 45595336
SGTC_716 1683-5115 658 µM -0.786582644012945 0.233978640589159 no 2610 0.21576311128973 3806 723597
SGTC_340 k038-0059 454 µM -0.78671985066021 0.233939718327845 no 2611 0.215722940522908 3809 23733424
SGTC_1578 josamycin 24.2 µM -0.787696375586678 0.233662805081439 no 2612 0.215437163055683 3820 5282165 A P450 substrate.
SGTC_3190 9110366 49.47 µM -0.78845518841582 0.233447754001394 no 2613 0.215215250173184 3761 17123768
SGTC_2396 5342950 42.78 µM -0.788621106199586 0.233400746762903 no 2614 0.215166745621212 3836 1886677
SGTC_662 k832-1615 104 µM -0.789401219376976 0.233179798267726 no 2615 0.214938771719074 3859 5878478
SGTC_579 4491-1009 110 µM -0.790875019962905 0.23276269637082 no 2616 0.214508463351908 3947 1271041
SGTC_2480 5767542 37.17 µM -0.79188481727344 0.232477152066561 no 2617 0.214213920273101 3814 2867358
SGTC_2136 5328288 199.296 µM -0.794382215391266 0.231771790460081 no 2618 0.213486477234111 3841 262395
SGTC_3125 9127534 49.47 µM -0.794474968941983 0.231745616261672 no 2619 0.213459487702949 3668 1639235
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.795064641623457 0.231579254579079 no 2620 0.213287950607098 3851 23665772 A membrane-active detergent.
SGTC_1520 flindersine 88 µM -0.79538028365755 0.231490231281632 no 2621 0.213196162673132 3958 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_157 1348-1695 65.819 µM -0.795493099909209 0.231458417351478 no 2622 0.213163361571376 3796 5380510
SGTC_2032 5185112 25.99 µM -0.796070240205762 0.23129570322229 no 2623 0.212995605223952 3752 5718189
SGTC_1452 4194-0072 190 µM -0.796240895933787 0.231247602192928 no 2624 0.212946015786186 3832 1343545
SGTC_2675 theaflavin digallate 100 µM -0.796393957708452 0.231204464943431 no 2625 0.212901544561658 3795 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2099 5377090 177.372 µM -0.798244909844916 0.230683168484889 no 2626 0.212364190221033 3856 2243829
SGTC_3343 9148379 18.9835 µM -0.798389962567386 0.230642344047241 no 2627 0.212322113132315 3879 1955036
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.799068193183206 0.23045151265814 no 2628 0.21212543574444 3889 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1249 0481-0015 10.2 µM -0.799115072138241 0.230438325751575 no 2629 0.212111845440364 3773 4227577
SGTC_958 1222-0007 33 µM -0.801325727491675 0.229816954340674 no 2630 0.211471550227571 3905 7312461
SGTC_2513 baicalein 25.65 µM -0.80156452683921 0.229749888764725 no 2631 0.211402452076767 3838 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_654 1124-0271 80.9 µM -0.802479606268038 0.229492994878933 no 2632 0.211137790318795 3838 5403748
SGTC_1836 st055642 81 µM -0.804902560543729 0.228813567236545 no 2633 0.2104379553481 3853 8571
SGTC_1752 st044819 83.042 µM -0.804997813156085 0.228786880261576 no 2634 0.210410470867462 3846 441209 YML126C ERG13
SGTC_231 b-estradiol 524 µM -0.805237399245639 0.228719763024924 no 2635 0.210341349279816 3778 450 A steroid.
SGTC_2073 5212005 126 µM -0.806179167669675 0.228456044794467 no 2636 0.210069774388312 3673 691789
SGTC_2958 9077254 16.72 µM -0.806812329452911 0.228278840065326 no 2637 0.209887307315106 3874 16457351
SGTC_1983 st071813 46.9 µM -0.807347786034586 0.228129040675306 no 2638 0.20973307004072 3915 11838595
SGTC_1827 berberine 7.24 µM -0.807562057861801 0.228069111454867 no 2639 0.209671368113223 3780 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2708 st078559 56 µM -0.807762663577771 0.228013012505016 no 2640 0.20961361116884 3812 17250902
SGTC_1657 st012939 43.4 µM -0.807908965136041 0.227972104488847 no 2641 0.20957149498529 3850 24207257
SGTC_875 0709-0210 25.7 µM -0.810634737222498 0.227210694910466 no 2642 0.208787731030568 3818 6251364
SGTC_2240 6690706 185.951 µM -0.810908364285603 0.227134339930721 no 2643 0.208709148272868 3739 805876
SGTC_2266 7929956 200 µM -0.811014594331939 0.227104700587775 no 2644 0.208678644841012 3802 2967153
SGTC_1026 k007-1105 30.6 µM -0.811324340486409 0.227018290477266 no 2645 0.208589717768978 3846 7066794
SGTC_1278 0874-0585 172 µM -0.812140164595121 0.226790788172127 no 2646 0.208355604369504 3909 766306
SGTC_16 erodoxin 22.806 µM -0.812417649909477 0.226713437400898 no 2647 0.208276010986232 3876 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.814070228095694 0.226253079340899 no 2648 0.207802360129738 3841 688751
SGTC_1744 st037937 38.9 µM -0.815557924557025 0.225839104412979 no 2649 0.207376511203616 3914 1016152
SGTC_771 0250-0039 27.3 µM -0.81640196468009 0.225604427569158 no 2650 0.207135136658907 3828 3005115
SGTC_1837 st055472 66.5 µM -0.816813514943965 0.225490050234366 no 2651 0.207017503786382 3942 676091
SGTC_1305 1181-0477 144 µM -0.819094644967523 0.224856678027483 no 2652 0.206366208466239 3886 6252086
SGTC_2217 6934799 96.0675 µM -0.819470507937786 0.224752413833165 no 2653 0.206259010837224 3790 675606
SGTC_886 0866-0150 153 µM -0.821247450609225 0.224259862205405 no 2654 0.205752666694261 3910 271463
SGTC_394 menadione 8.33 µM -0.82370771892043 0.223578911993046 no 2655 0.20505282623827 3839 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2593 nobiletin 86.24 µM -0.824008461028035 0.223495753675585 no 2656 0.204967375205007 3881 72344 An anti-infammatory.
SGTC_2746 daunorubicin 9.88 µM -0.829168582653032 0.222071669938285 no 2657 0.203504510012682 3763 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3076 9116187 49.47 µM -0.829437878225199 0.221997492583322 no 2658 0.203428337619754 3867 27241210
SGTC_1031 k035-0009 16 µM -0.829740358498978 0.221914191387107 no 2659 0.203342798956319 3958 5180959
SGTC_561 1550-0330 72.9 µM -0.830605973062393 0.221675905148599 no 2660 0.203098129669955 3823 6812934
SGTC_897 1000-0139 31.4 µM -0.83135796798403 0.221469014835242 no 2661 0.202885718152624 3835 6151020
SGTC_452 diindolylmethane 8 µM -0.831994327827449 0.221294024535055 no 2662 0.202706073086568 3884 3071 Inhibits expression of several cancer promoting factors.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.832161641324548 0.221248028731995 no 2663 0.202658856093002 3902 1273210
SGTC_2520 obtusaquinone 4.71 µM -0.832428201189141 0.221174760615196 no 2664 0.202583644686706 3890 5967872
SGTC_1892 st058411 7.36 µM -0.83293131388212 0.22103651011291 no 2665 0.202441734004526 3902 3934738
SGTC_1269 0831-0796 3.05 µM -0.833236521971456 0.220952665988526 no 2666 0.202355674337135 3911 927758
SGTC_1850 st056238 17 µM -0.834947680628223 0.220482928580919 no 2667 0.201873583473502 3893 5393177
SGTC_3287 9117173 37.0625 µM -0.835388990505307 0.220361875633482 no 2668 0.201749363287089 3860 2789709
SGTC_486 niguldipine 82 µM -0.841087571133659 0.218802159723045 no 2669 0.200149438711313 3914 1236 A calcium channel blocker.
SGTC_2355 9061122 103.12 µM -0.842128477362254 0.218517948764505 no 2670 0.199858021368713 3920 5302957
SGTC_2059 5238311 157 µM -0.842793175427094 0.218336569647103 no 2671 0.199672062736938 3887 703021
SGTC_829 1635-0120 117 µM -0.843822711229504 0.218055806900875 no 2672 0.199384241203423 3911 285054
SGTC_686 1319-0111 510 µM -0.845656995398307 0.217556098834722 no 2673 0.198872060088593 3904 4562600
SGTC_1056 3448-1962 115 µM -0.845979297980204 0.21746836331079 no 2674 0.198782146588637 3894 715507
SGTC_1913 st060213 96.1 µM -0.84600770775224 0.217460630730834 no 2675 0.198774222224075 3940 688959
SGTC_429 1112-0049 25.5 µM -0.846244637295021 0.217396149361351 no 2676 0.19870814266046 3874 2836170
SGTC_2782 7736369 71.43 µM -0.846891799985311 0.217220077588351 no 2677 0.198527716735836 3949 2950836 YOL077C BRX1
SGTC_57 miconazole 162.5 nM -0.846993490224245 0.217192418495122 no 2678 0.198499374960852 3854 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_805 3852-0218 479 µM -0.847194919050867 0.217137637151844 no 2679 0.198443242556032 3836 6615355
SGTC_1938 st074717 56.4 µM -0.84771199103532 0.216997048858075 no 2680 0.19829919335945 3731 17250979
SGTC_1006 4099-6547 255 µM -0.84816243819676 0.216874618279582 no 2681 0.19817375637884 3944 3146833
SGTC_1315 1237-0019 3.69 µM -0.849015833403397 0.216642776807503 no 2682 0.197936240981671 3915 825140
SGTC_2879 9041815 71.43 µM -0.850232013160488 0.216312625678109 no 2683 0.197598053330535 3906 4942971
SGTC_725 1497-0963 19 µM -0.850415515244942 0.216262836450682 no 2684 0.197547056563396 3959 3549977
SGTC_1109 tnp00067 928.257 nM -0.850689025010537 0.216188637947932 no 2685 0.197471060677106 3892 676295
SGTC_2177 5811945 192 µM -0.851325082047814 0.216016143608477 no 2686 0.197294397811866 3938 5343475
SGTC_1199 1638-0010 4.46 µM -0.851721232595518 0.215908750580542 no 2687 0.197184416558068 3886 3111136
SGTC_1963 st076565 50.3 µM -0.851788249804284 0.215890585847981 no 2688 0.197165814581711 3917 4914280
SGTC_1486 3970-0793 4.53 µM -0.852177004878472 0.215785232889546 no 2689 0.19705792872538 3947 2844330
SGTC_2522 biochanin a 4.94 µM -0.852953512174059 0.215574887974674 no 2690 0.196842542300923 3905 5280373 A possible chelator.
SGTC_277 nystatin 15.5 µM -0.853229271602001 0.21550021724142 no 2691 0.19676608687891 3890 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2643 anethole 100 µM -0.855870028509506 0.214785907459984 no 2692 0.19603483739071 3917 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.857833570539723 0.214255673319217 no 2693 0.195492184864353 3903 688761
SGTC_2940 9060638 45.86 µM -0.860991522318557 0.213404500307765 no 2694 0.194621356134878 3929 4027022
SGTC_2801 7907800 81.82 µM -0.862727160580057 0.212937528675026 no 2695 0.194143747724742 3966 6620925
SGTC_2286 7945697 125 µM -0.863506926289486 0.212727927815517 no 2696 0.193929406458471 3950 1245733
SGTC_1741 st038134 10.228 µM -0.863995044019256 0.212596783197094 no 2697 0.193795306536504 3983 1272587
SGTC_3075 9116269 49.47 µM -0.864709226373529 0.212404985966346 no 2698 0.193599202075319 3944 17015205 YNL244C SUI1
SGTC_985 1493-0307 8.71 µM -0.865828594565157 0.212104577559248 no 2699 0.193292082858545 3952 3278274
SGTC_1130 3454-2858 15.9 µM -0.868603219342277 0.211361014625094 no 2700 0.192532096507314 3978 715628 YIL048W NEO1
SGTC_211 3455-0679 143.504 µM -0.870396679919598 0.210881204263692 no 2701 0.192041830228937 3990 748649
SGTC_1988 st071872 53.4 µM -0.870399005216777 0.210880582584231 no 2702 0.192041195074363 3955 16414116
SGTC_2300 7976697 71.57 µM -0.870633157563797 0.210817986323366 no 2703 0.19197724297847 3837 2236109
SGTC_2985 9022375 71.43 µM -0.871852934305041 0.210492078059132 no 2704 0.191644306288627 3996 4939335
SGTC_2717 st081029 62.2815 µM -0.872195098483594 0.210400709439247 no 2705 0.191550976512657 3917 5292846
SGTC_1865 st057639 52.2 µM -0.874143917694106 0.209880757410041 no 2706 0.19101994154616 3914 688818
SGTC_1361 1608-0041 5.61 µM -0.874613174180327 0.209755670993174 no 2707 0.190892208559711 3891 X1361
SGTC_1104 tacrolimus 29.8 µM -0.874869031684024 0.209687487317747 no 2708 0.190822585479061 3954 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_40 0327-0103 19.753 µM -0.875570010283357 0.209500749737957 no 2709 0.190631917380075 3827 409036
SGTC_2180 6301957 200 µM -0.875807146235939 0.209437599928183 no 2710 0.190567442232576 3921 845462
SGTC_1831 st055328 12 µM -0.87625230166043 0.209319084340331 no 2711 0.190446444607739 3911 1103068
SGTC_1143 3454-2408 5.08 µM -0.876511218124243 0.209250170087567 no 2712 0.19037609026953 3865 X1143
SGTC_1045 1348-1485 165 µM -0.876893643543229 0.209148406626727 no 2713 0.190272204540007 3943 6810614
SGTC_2596 sinensetin 100 µM -0.877001169735264 0.209119799140108 no 2714 0.190243001361556 3967 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_681 1642-0006 26.6 µM -0.877521435046798 0.208981414408078 no 2715 0.190101740725909 3943 4446530
SGTC_459 nigericin 15.3 µM -0.877576442120537 0.208966786297584 no 2716 0.19008680916451 3987 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1244 0416-0015 52.5 µM -0.879251472114307 0.208521632033869 no 2717 0.189632470784476 3922 96201
SGTC_3084 9116877 49.47 µM -0.880622692601099 0.208157634444115 no 2718 0.189261035999659 3813 27241325
SGTC_2451 5856223 45.7 µM -0.88095033938086 0.208070714442471 no 2719 0.189172349723126 3914 2179896
SGTC_2258 7960471 200 µM -0.881723078546484 0.207865802663996 no 2720 0.188963288775618 3981 2974708
SGTC_188 3229-0966 278.469 µM -0.883738712192157 0.207331866412071 no 2721 0.188418638767245 3979 5722370
SGTC_1568 digitonin 820 nM -0.883929776296992 0.207281296125835 no 2722 0.18836706108935 3918 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2393 9031399 185.94 µM -0.885540904607918 0.206855157564356 no 2723 0.187932484083029 4000 1526623 YDL150W RPC53
SGTC_3160 9100216 49.47 µM -0.885976488000055 0.206740036188404 no 2724 0.187815098570753 3845 17191039
SGTC_2065 5221596 34.26 µM -0.886800918007391 0.206522249482683 no 2725 0.187593046647806 3946 788581
SGTC_1546 5-methoxyflavanone 78.7 µM -0.887638768639346 0.206301056799387 no 2726 0.187367546283051 3935 147795
SGTC_2843 9000894 45.46 µM -0.887693993444059 0.206286482377239 no 2727 0.187352688885722 3866 2242070
SGTC_491 tetrandrine 80.3 µM -0.888080773119184 0.206184424150865 no 2728 0.187248652086132 3970 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_305 1682-2595 20.8 µM -0.888408967534409 0.206097848096524 no 2729 0.187160401692771 3981 226033
SGTC_1716 st033144 30.6155 µM -0.888685211275816 0.206024993081749 no 2730 0.187086140604901 3944 674617
SGTC_2836 9010338 19.48 µM -0.891359477792309 0.205320486621094 no 2731 0.186368174801557 3966 2994051
SGTC_1071 trifluoperazine 6.31 µM -0.8927872938387 0.204944930701599 no 2732 0.185985546011679 4072 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2798 7813637 45.45 µM -0.894989797384753 0.20436641166444 no 2733 0.185396270976158 3982 956368
SGTC_1762 st045503 25.4615 µM -0.89789985343095 0.20360353648092 no 2734 0.184619471412825 4056 4645554
SGTC_3264 9137442 49.47 µM -0.898339513041916 0.203488426960946 no 2735 0.184502286539853 3943 17015726
SGTC_2568 diosmetin 100 µM -0.898393205861059 0.203474372031124 no 2736 0.184487978670651 4017 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2056 5235370 200 µM -0.899350315137114 0.203223930982733 no 2737 0.184233047443957 3934 5511916
SGTC_1298 1079-1278 263 µM -0.899763323919681 0.203115918299869 no 2738 0.184123108067837 3982 2840950
SGTC_1033 k072-0102 21.3 µM -0.899968134746826 0.20306236758485 no 2739 0.184068604342195 3951 5965931
SGTC_1213 1315-0166 115 µM -0.900145868911169 0.203015903282525 no 2740 0.184021314328866 4064 768401
SGTC_887 0885-0007 9.62 µM -0.901531677150598 0.202653834994403 no 2741 0.183652849589912 4058 5719458
SGTC_1343 1487-0095 224 µM -0.902214121345448 0.202475675607983 no 2742 0.183471567403549 3978 4560101 YGL055W OLE1
SGTC_3097 9117246 49.47 µM -0.902682959416222 0.202353334677243 no 2743 0.183347091490832 3983 16423892
SGTC_3108 9121785 49.47 µM -0.903095339921168 0.20224576261615 no 2744 0.183237648526922 3838 17140271
SGTC_1523 st012844 44.7 µM -0.903760847255038 0.202072232988713 no 2745 0.183061113384966 4106 4274103
SGTC_2774 tamoxifen 10.92 µM -0.904618569907306 0.201848715091639 no 2746 0.18283374700051 3982 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2024 5144227 134 µM -0.905033591275111 0.201740615924875 no 2747 0.182723795830852 4055 3475211
SGTC_2645 abamectin 100 µM -0.90681165980945 0.20127788122364 no 2748 0.182253201465677 3929 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1738 st035555 74 µM -0.908127290459209 0.200935903944274 no 2749 0.181905486722148 4053 5331140
SGTC_3096 9117468 49.47 µM -0.90869688012503 0.200787956359791 no 2750 0.181755075740799 3895 41316311
SGTC_2874 9043904 71.43 µM -0.908828791747783 0.200753702413341 no 2751 0.181720253067909 3942 4463428
SGTC_2054 5233173 129 µM -0.912200609634728 0.199879321994281 no 2752 0.180831561541438 4020 6889
SGTC_353 1988-1175 58.3 µM -0.912249556511093 0.19986664597014 no 2753 0.180818680974716 3828 2788357
SGTC_2247 cerulenin 830 nM -0.912731591753079 0.199741836653758 no 2754 0.180691862190851 4018 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2272 7805186 180 µM -0.913625955464274 0.199510390844456 no 2755 0.180456711568923 3995 2956062 YPR165W RHO1
SGTC_1814 st052110 31.539 µM -0.91613015193558 0.198863207530218 no 2756 0.179799317466743 3923 674163
SGTC_3012 9080433 71.4286 µM -0.916168965443969 0.198853186555206 no 2757 0.179789140115345 3965 17688859
SGTC_2139 5578692 56.4705 µM -0.916329683921188 0.19881169507041 no 2758 0.179747001721208 3939 650991 YMR113W FOL3
SGTC_335 4077-0256 27.6 µM -0.916601190698357 0.198741614057143 no 2759 0.179675830102989 3975 3121989
SGTC_723 4182-0001 115 µM -0.919553460722791 0.197980539486127 no 2760 0.178903078175783 4016 744821 YLR208W SEC13
SGTC_2 0422-0095 29 µM -0.920293377228274 0.197790070410945 no 2761 0.178709734508617 3877 6790840
SGTC_2504 purpurogallin 52.29 µM -0.92149187264527 0.197481789111979 no 2762 0.178396841259796 3905 5281571 An antioxidant.
SGTC_271 rotenone 740 µM -0.923130894936178 0.197060664553357 no 2763 0.17796949803961 4033 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1287 0971-0001 34.6 µM -0.923325353349586 0.197010737191728 no 2764 0.177918839657423 3983 4665869
SGTC_1563 conessine 56.1 µM -0.924506597280639 0.196707616365753 no 2765 0.177611309106587 4071 441082 An anti-amoebic, histamine inhibitor.
SGTC_101 0490-5701 117.494 µM -0.926007502731328 0.196322874452253 no 2766 0.177221040597227 3814 4661669
SGTC_2446 5162541 200 µM -0.926609177262942 0.196168769455517 no 2767 0.177064744143508 3975 1549321
SGTC_938 3126-1755 342 µM -0.926785667266441 0.196123579546738 no 2768 0.17701891401751 4015 1777771
SGTC_937 3122-0005 46.7 µM -0.926917600743471 0.196089802370653 no 2769 0.176984659024869 4047 759535
SGTC_1264 0783-0040 158 µM -0.927659539100557 0.195899919464487 no 2770 0.176792101376558 3896 2855798
SGTC_1924 st058459 75.1 µM -0.932067712872404 0.194774046067259 no 2771 0.175650766332222 3975 688683
SGTC_154 3389-1638 511.116 µM -0.933870778620871 0.194314669010165 no 2772 0.175185276929461 4026 5238686
SGTC_3286 9117135 37.221 µM -0.935941012738088 0.193788038338387 no 2773 0.174651779684105 3985 3438150
SGTC_3103 9120822 49.47 µM -0.936005998887832 0.193771521116975 no 2774 0.174635049534934 4042 17141819
SGTC_2483 5729050 27.16 µM -0.937135590122829 0.193484555400976 no 2775 0.174344408153486 4004 2865180
SGTC_1334 1486-0610 236 µM -0.937498936539922 0.193392304609212 no 2776 0.174250985268516 4103 3742339
SGTC_220 paclitaxel 373.376 µM -0.937749715160974 0.193328649549419 no 2777 0.174186524142778 3983 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3132 9126706 49.47 µM -0.938817297158649 0.193057808636735 no 2778 0.173912278270769 4091 850858
SGTC_1976 st070609 63.5 µM -0.940033046467063 0.192749660614969 no 2779 0.173600305000081 3917 682556
SGTC_1856 st057054 55.7 µM -0.940148051763506 0.192720526541713 no 2780 0.173570811953401 4053 1266018
SGTC_2888 9058547 12.99 µM -0.940213558029506 0.192703933166676 no 2781 0.173554014331951 3924 16476514
SGTC_1855 st056195 39.6 µM -0.942564285856273 0.192109048842326 no 2782 0.172951907336922 3977 4028379
SGTC_499 genistein 192 µM -0.949128118442495 0.19045393813333 no 2783 0.17127772744832 4072 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3253 9135987 49.47 µM -0.950047048887446 0.190222924934533 no 2784 0.171044173379663 4035 4182430
SGTC_2233 sulbentine 40.3845 µM -0.95044623994865 0.19012262453022 no 2785 0.170942779039166 4018 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3177 9107506 49.47 µM -0.953041163415912 0.189471418847985 no 2786 0.170284607426855 3974 8897194
SGTC_392 N-ethylmaleimide 8.33 µM -0.95499397938717 0.18898225872519 no 2787 0.169790370808548 3974 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_265 mycophenolic acid 32.932 µM -0.955463091127668 0.188864867096281 no 2788 0.16967178086601 4127 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_664 1222-0054 14.9 µM -0.959455786881704 0.187867545101899 no 2789 0.168664591391787 4007 6813991
SGTC_1697 st025554 27.742 µM -0.959602508915418 0.187830957957177 no 2790 0.168627652933308 4009 1269519
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.960335741434828 0.187648182355796 no 2791 0.168443133650463 4009 756377
SGTC_3006 9075424 71.4286 µM -0.962170844791181 0.187191221159446 no 2792 0.167981895920514 3989 7465181
SGTC_2201 6605497 169.863 µM -0.962643733165545 0.187073578289045 no 2793 0.167863171271658 3966 670741
SGTC_1133 3473-0247 50 µM -0.963587778803192 0.186838860024463 no 2794 0.167626318200886 4040 711311
SGTC_851 0394-0702 453 µM -0.965417069186014 0.186384562201125 no 2795 0.167167977683407 4062 762646
SGTC_2779 methotrexate 400 µM -0.965793582659345 0.186291141392909 no 2796 0.167073740156599 4071 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3299 9121982 43.1275 µM -0.966445078429375 0.186129560317847 no 2797 0.166910758266805 4117 17594604 YPL160W CDC60
SGTC_2288 7946289 167.31 µM -0.966532217244092 0.186107955125892 no 2798 0.166888966903076 4117 1246052
SGTC_2600 tangeritin 87.95 µM -0.96728791611991 0.185920652399182 no 2799 0.166700061399085 3991 68077 A bioactive flavone.
SGTC_804 1595-0054 20.9 µM -0.969355703049638 0.185408741649799 no 2800 0.166183872856937 3988 761523 Stimulates phospholipase C.
SGTC_1699 st031318 29.054 µM -0.972357775543594 0.184667093931397 no 2801 0.16543629519042 4099 5340658
SGTC_685 1278-0033 54.9 µM -0.974341493414306 0.184178039449736 no 2802 0.164943504373192 4107 3590572
SGTC_945 3381-0768 11.3 µM -0.974925269547102 0.184034272273038 no 2803 0.164798665207161 4107 1126236 YIL048W NEO1
SGTC_759 3486-0358 89.3 µM -0.977603877281458 0.183375504842516 no 2804 0.164135139478283 4060 875103
SGTC_1722 st034304 3.6505 µM -0.978639398352542 0.183121226943087 no 2805 0.163879092605375 4059 4036148 YLR033W RSC58
SGTC_2565 isoliquiritigenin 100 µM -0.979667079243939 0.182869091813969 no 2806 0.163625240733997 4163 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_373 0844-0104 25.9 µM -0.980242367367699 0.182728043084757 no 2807 0.163483247865217 4089 5375804
SGTC_3296 9122258 64.045 µM -0.98028524380201 0.182717533391815 no 2808 0.163472668290161 4066 4730474
SGTC_1933 st074711 15.9 µM -0.980325816003543 0.182707588850333 no 2809 0.163462657684055 4033 17250958
SGTC_2227 7312221 64.1025 µM -0.983356682746854 0.18196565709244 no 2810 0.162715960859772 4143 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2325 6158266 200 µM -0.984367120941495 0.181718729293885 no 2811 0.162467519034075 4105 3623240
SGTC_3293 9120939 62.045 µM -0.984445676594606 0.181699540890285 no 2812 0.162448214484097 4073 934087
SGTC_120 rhodamine 6G 52.259 µM -0.987634345347884 0.180921730791408 no 2813 0.161665879675122 4094 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_772 k072-0172 35.3 µM -0.98790580669693 0.180855609906612 no 2814 0.161599390684884 4120 5861980
SGTC_2814 7977482 42.97 µM -0.987906006117435 0.180855561338561 no 2815 0.161599341847401 4145 6456762
SGTC_2796 7949634 45.45 µM -0.988637180081246 0.180677541866684 no 2816 0.161420344227799 4033 2971588
SGTC_49 0717-0965 32.132 µM -0.989335750325043 0.180507563117083 no 2817 0.161249449098471 4166 5889349 YGL099W LSG1
SGTC_2011 4012611 177 µM -0.990265434156581 0.180281504565714 no 2818 0.16102219848738 4077 2049887
SGTC_1791 st048313 56.1 µM -0.991449281384684 0.179993901843626 no 2819 0.160733123221202 4086 1204976
SGTC_612 0302-0167 22.4 µM -0.991949139137355 0.179872553427385 no 2820 0.160611168313416 4088 235821
SGTC_1322 1348-1070 12 µM -0.992398533401315 0.179763499700929 no 2821 0.160501577056149 4075 6758089
SGTC_1790 st045711 43.5 µM -0.992512715585083 0.179735797927441 no 2822 0.160473739872745 4079 585119
SGTC_2354 9060492 162 µM -0.993363207228254 0.179529544293724 no 2823 0.160266492492212 4139 6471895
SGTC_600 1495-0418 41.6 µM -0.997003876562154 0.178648324056723 no 2824 0.15938131414487 4074 5377768
SGTC_3024 9090631 49.47 µM -0.998880674376793 0.178195112902627 no 2825 0.158926249544778 4059 25236383
SGTC_955 1216-0110 33 µM -0.999975945839327 0.177930960730517 no 2826 0.158661074404145 4068 3619719
SGTC_102 gallobenzophenone 83.616 µM -1.00014669281341 0.177889803077283 no 2827 0.158619761168572 4100 70837
SGTC_3342 9147791 14.508 µM -1.00057317451319 0.177787028154666 no 2828 0.158516602226424 3984 1838168
SGTC_1060 3448-7350 82 µM -1.00095928592134 0.177694014107134 no 2829 0.15842324615633 4054 570178
SGTC_2654 protoveratrine a 100 µM -1.00242232068552 0.177341848411045 no 2830 0.15806983313772 4075 5702278 A heart drug and vasodilator.
SGTC_2175 5807670 165.306 µM -1.00738254076555 0.176151161349733 no 2831 0.156875489066919 4076 241186
SGTC_297 0986-0032 24 µM -1.00846413238544 0.17589220182558 no 2832 0.156615849159721 4044 2847425
SGTC_1989 st071868 50.2 µM -1.01180924235493 0.175092827456738 no 2833 0.155814635013029 4082 16414057
SGTC_365 0121-0052 13.6 µM -1.01343103426663 0.174706101849377 no 2834 0.155427161058435 4142 3101739
SGTC_2166 5933061 31.504 µM -1.01419155288385 0.174524938725566 no 2835 0.155245679255457 4218 2877375
SGTC_344 k064-0035 6.43 µM -1.01544262894495 0.174227179593335 no 2836 0.154947440632697 4060 5088750
SGTC_1465 k213-0056 144 µM -1.01927376979815 0.173317368253541 no 2837 0.154036506542298 3988 24048857 YMR208W ERG12
SGTC_1929 genistein trimethyl ether 50.5 µM -1.02055763958868 0.173013155444033 no 2838 0.153732033815161 4101 136420
SGTC_3309 9129340 25.759 µM -1.02208369079149 0.172652000542697 no 2839 0.153370645774723 4127 17158987
SGTC_844 0330-0132 15.3 µM -1.02588026358735 0.171755591612851 no 2840 0.152474013350968 4167 2828079
SGTC_3111 9122088 49.47 µM -1.02882899485174 0.171061421405562 no 2841 0.151780019571786 3966 16876704
SGTC_847 0342-0274 5.54 µM -1.03219042721023 0.170272287955498 no 2842 0.15099145931501 4124 18097
SGTC_2618 avocadyne 43.43 µM -1.03308972738533 0.170061563352754 no 2843 0.15078095511993 4035 3015189
SGTC_2648 atorvastatin 78.68 µM -1.0338232233379 0.169889813918533 no 2844 0.150609406383326 4125 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2828 7998861 71.43 µM -1.03732599300704 0.169071168192382 no 2845 0.149791977923645 4105 2988188
SGTC_1677 st019204 53.9 µM -1.03772953506658 0.168977017842583 no 2846 0.149697995267533 4153 3945625
SGTC_199 4063-0024 41.6 µM -1.03961204894907 0.168538253850937 no 2847 0.149260088378573 4136 306215
SGTC_1817 st052116 64.4 µM -1.04097390079649 0.168221299367606 no 2848 0.148943830661551 4151 4361398
SGTC_34 0469-0683 81.75 µM -1.04176707573089 0.168036874353593 no 2849 0.14875984110141 4099 3690923
SGTC_2404 5161160 200 µM -1.04347636108578 0.167639882513945 no 2850 0.148363861739077 4094 2831543
SGTC_393 acivicin 6.25 µM -1.04381174678139 0.167562058111982 no 2851 0.148286247864192 3995 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1191 1487-1166 10.6 µM -1.04495201784263 0.167297638601857 no 2852 0.148022573202843 4179 3955771
SGTC_2602 kawain 100 µM -1.04507768210202 0.167268514551363 no 2853 0.147993533986881 4143 5369129
SGTC_1620 st003704 16.5 µM -1.04557992497702 0.167152146969093 no 2854 0.147877510907506 4103 2834414
SGTC_73 0327-0325 16.231 µM -1.04570497785904 0.16712318085467 no 2855 0.14784863192439 4004 53298
SGTC_2027 5150920 200 µM -1.0479319334357 0.166607891121691 no 2856 0.147334984150115 4084 786715
SGTC_2222 6885208 172.143 µM -1.05082357881825 0.165940332343292 no 2857 0.146669812172523 4095 609514
SGTC_984 1492-0255 2.91 µM -1.0509843492848 0.165903268028738 no 2858 0.146632888991337 4112 1585198
SGTC_628 1636-0253 16 µM -1.05149519307672 0.165785532690653 no 2859 0.146515607988112 4140 4456143
SGTC_2022 5136654 200 µM -1.05286510319702 0.16547007308203 no 2860 0.146201410932677 4194 1713771
SGTC_537 1334-0398 209 µM -1.05414153853875 0.165176488315421 no 2861 0.145909060430211 4200 5846986
SGTC_587 k089-0003 57 µM -1.05458596618006 0.165074347522815 no 2862 0.14580736246841 4024 9659696
SGTC_2927 9011802 47.9 µM -1.05478458448933 0.165028713199427 no 2863 0.145761928233626 4162 43912568
SGTC_2341 7987486 176.74 µM -1.05604997477212 0.164738170331525 no 2864 0.145472691779241 4185 1258686
SGTC_2108 5365811 200 µM -1.0561131784144 0.164723667007177 no 2865 0.145458255141699 4156 780283
SGTC_2080 5212524 12.4 µM -1.05758483852058 0.164386199406449 no 2866 0.145122378844022 4038 260183
SGTC_1382 3002-2117 298 µM -1.05873319254075 0.164123180937311 no 2867 0.144860653373606 4225 1497314
SGTC_1852 st056254 31.4 µM -1.05881874589739 0.164103596767852 no 2868 0.144841167331381 4087 442583
SGTC_2902 5787006 60.46 µM -1.05902082566214 0.164057344352262 no 2869 0.144795147684791 4116 591003
SGTC_2237 6667747 47.222 µM -1.05975735503122 0.16388883764509 no 2870 0.14462750112394 4151 729940 YDL015C TSC13
SGTC_988 1497-1057 103 µM -1.06081646361508 0.16364672666871 no 2871 0.144386659349027 4114 3533044
SGTC_2317 5986382 200 µM -1.06208396788805 0.163357282087247 no 2872 0.144098783789538 4176 877883
SGTC_259 usnic acid 108.925 µM -1.06215437895909 0.163341212921014 no 2873 0.144082803382569 4239 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1848 st056003 16.4 µM -1.06565314000484 0.162544021444391 no 2874 0.143290233939505 4175 146492
SGTC_2279 7948423 32.93 µM -1.06589878362466 0.162488146899446 no 2875 0.143234699461546 4147 1247112
SGTC_3065 9113888 49.47 µM -1.06782748258326 0.16204987590778 no 2876 0.142799169341586 4236 16648368
SGTC_155 k072-0202 43.6 µM -1.0679993141819 0.162010866866958 no 2877 0.142760410578542 4120 5857737
SGTC_409 arachidonic acid 100 µM -1.06994071065044 0.161570557925307 no 2878 0.142322998436373 4150 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3340 9146634 11.102 µM -1.07104698944409 0.161320003029577 no 2879 0.142074150961796 4186 4907387
SGTC_2165 5727197 32.143 µM -1.07174174174918 0.1611627820888 no 2880 0.141918023316314 4319 1361712
SGTC_592 k241-0073 46.5 µM -1.07295717657707 0.160887972338534 no 2881 0.141645165191839 4200 4230158
SGTC_1774 st048371 48.465 µM -1.07438473273247 0.160565592840109 no 2882 0.141325141157792 4154 4242727
SGTC_2646 retinol 96.75 µM -1.07568962432395 0.16027128359407 no 2883 0.141033044649685 4173 445354 A vitamin A analog and teratogen.
SGTC_1151 3909-8316 15.3 µM -1.07692273070664 0.159993489235349 no 2884 0.140757393597551 4210 800431
SGTC_1581 himbacine 57.9 µM -1.07808326624162 0.15973233144372 no 2885 0.140498299329284 4162 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_597 k018-0003 82.8 µM -1.08011289737154 0.15927627003241 no 2886 0.140045954626452 4240 6786234
SGTC_2382 9035899 200 µM -1.08202332394206 0.15884777393197 no 2887 0.139621082096689 4168 6462679
SGTC_1696 st025591 34.7925 µM -1.08208441498637 0.158834084091427 no 2888 0.13960751012909 4187 2787147
SGTC_228 caffeine 993.056 µM -1.08411338508508 0.158379853251799 no 2889 0.139157264405741 4197 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3292 9120825 59.784 µM -1.08454388340611 0.158283586164505 no 2890 0.139061860396951 4184 24824900
SGTC_1626 st003712 1.76 µM -1.08512497501256 0.158153704639987 no 2891 0.138933153588538 4213 24207035
SGTC_703 3875-0075 71.8 µM -1.08590503598321 0.1579794608832 no 2892 0.138760504327818 4224 2850814
SGTC_2704 st078022 71.1 µM -1.08629061918159 0.157893378969511 no 2893 0.138675217995451 4226 54697681
SGTC_1939 st074455 53.6 µM -1.08629257741246 0.157892941870736 no 2894 0.138674784949661 4194 1644229
SGTC_2698 st077697 67.5 µM -1.08697118225409 0.15774151761673 no 2895 0.138524772837857 4150 3154499
SGTC_862 0452-0056 10.2 µM -1.08753202089743 0.15761644379442 no 2896 0.1384008775585 4134 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_810 3825-7150 143 µM -1.094097032418 0.156157213175186 no 2897 0.136956211917339 4269 22330411 YGL099W LSG1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.09475268014379 0.156011970260866 no 2898 0.136812501220549 4123 4330530
SGTC_2644 guaiazulene 100 µM -1.09931715478698 0.155003289426029 no 2899 0.135814876133812 4205 3515 A coloring agent.
SGTC_2722 naftopidil 47.16 µM -1.1051334412193 0.15372423075442 no 2900 0.134550886045752 4132 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2914 7968218 45.32 µM -1.105390986295 0.153667756066633 no 2901 0.134495103894795 4162 2977111
SGTC_3188 9110789 49.47 µM -1.10780213597384 0.153139703615509 no 2902 0.133973638714141 4192 849217
SGTC_1232 0279-0259 161 µM -1.1078570602564 0.153127688980682 no 2903 0.133961776313197 4203 1560000
SGTC_2917 7979103 53.79 µM -1.1088375119065 0.152913321226725 no 2904 0.13375014240039 4227 2980565
SGTC_901 1112-0062 60.1 µM -1.10981763426932 0.152699224443411 no 2905 0.133538809404779 4217 1908457
SGTC_2271 7849410 118.62 µM -1.11042533010442 0.15256657998452 no 2906 0.133407894032234 4148 972430
SGTC_3225 9130819 49.47 µM -1.11066728464806 0.152513788780957 no 2907 0.133355794561541 4143 4547121
SGTC_2017 5132927 60.65 µM -1.11114301457541 0.152410026305818 no 2908 0.133253397639192 4194 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2545 solidagenone 89.61 µM -1.11141871442634 0.15234991426919 no 2909 0.13319408029977 4051 6708572 An anti ulcer agent
SGTC_32 0928-0142 34.1 µM -1.11238833056486 0.152138629662344 no 2910 0.132985609910332 4189 2244242
SGTC_489 paxilline 115 µM -1.11289118862758 0.152029130825773 no 2911 0.132877582412875 4195 105008 A toxic potassium channel blocker.
SGTC_2089 5281248 129.67 µM -1.11370607742766 0.151851797537259 no 2912 0.13270265060782 4189 2737878
SGTC_1020 4335-0961 93.3 µM -1.11411105758152 0.151763718296348 no 2913 0.132615772734009 4158 669075
SGTC_2318 6029776 164 µM -1.11474548556806 0.151625804649319 no 2914 0.132479751627457 4262 818325
SGTC_283 0987-0079 11.7 µM -1.1192518222758 0.150648603051324 no 2915 0.131516361426871 4206 411556
SGTC_3228 9131799 49.47 µM -1.12003818352072 0.150478510934277 no 2916 0.131348745486515 4209 17015818
SGTC_3019 9081971 49.47 µM -1.12115581113957 0.150236985190564 no 2917 0.131110772733216 4230 16451803
SGTC_472 calcifediol 10 µM -1.122435829347 0.149960683481784 no 2918 0.130838588780449 4265 5283731 A vitamin D metabolite.
SGTC_2367 9070478 135.38 µM -1.1235038145832 0.149730410171743 no 2919 0.130611790709949 4161 572802
SGTC_1522 st012842 45.6 µM -1.1246994945083 0.149472884039055 no 2920 0.130358197995113 4064 3491067 YOR116C RPO31
SGTC_1720 st037298 9.481 µM -1.12826218394254 0.148707303916668 no 2921 0.129604604519083 4212 597396
SGTC_2941 9056145 11.23 µM -1.13006693987207 0.148320484979166 no 2922 0.129224009509534 4147 2119517
SGTC_2764 methyldopa 94.69 µM -1.13051310040426 0.148224961864331 no 2923 0.129130040736135 4220 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3114 9122766 49.47 µM -1.13149714710243 0.148014422679033 no 2924 0.12892295176017 4233 17176985
SGTC_820 1582-0060 59.9 µM -1.13674939049153 0.146894078810168 no 2925 0.127821532814738 4241 3848840
SGTC_623 k072-0108 16.9 µM -1.13709864989884 0.146819781320743 no 2926 0.127748524138406 4199 5382803
SGTC_2947 9072639 7.68 µM -1.13767116693223 0.14669804507372 no 2927 0.127628908720736 4219 16488146
SGTC_3313 9133968 57.047 µM -1.13969036701776 0.146269236475841 no 2928 0.127207660908837 4227 1494643
SGTC_1818 st052136 56.3 µM -1.14347084249608 0.145468658920161 no 2929 0.126421576971372 3924 674169
SGTC_476 mead acid 10 µM -1.14576600677314 0.144984060673845 no 2930 0.125945991999429 4283 5312531 An omega 9 fatty acid.
SGTC_2353 9059630 146.67 µM -1.1504627489429 0.143995786877627 no 2931 0.124976664202028 4279 4779114
SGTC_629 3448-6466 76.7 µM -1.15158356623749 0.143760621063929 no 2932 0.124746118813911 4238 573744
SGTC_497 capsazepine 133 µM -1.15725008399819 0.142575661165732 no 2933 0.123585100372873 4202 2733484 A calcium channel blocker.
SGTC_3122 9126309 49.47 µM -1.15816292753431 0.142385390407073 no 2934 0.123398776987626 4299 17591206
SGTC_1800 st050079 29.0735 µM -1.16122108659895 0.141749207708795 no 2935 0.122776000786448 4101 3645560
SGTC_1431 4049-0260 9.09 µM -1.16126276554423 0.141740550640166 no 2936 0.122767528366692 4250 3854841
SGTC_2594 a-mangostin 100 µM -1.16252730688417 0.141478064979383 no 2937 0.122510669645484 4276 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_224 benfluorex 43.875 µM -1.16277168775035 0.141427375916735 no 2938 0.122461073531868 4276 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2010 4012422 159 µM -1.16544901576938 0.140872855142742 no 2939 0.121918643184258 4206 952393
SGTC_3265 9137266 49.47 µM -1.16577551743392 0.140805332066184 no 2940 0.121852609132996 4204 17224265
SGTC_2474 5321570 43.32 µM -1.16646298096453 0.14066323108113 no 2941 0.121713653707203 4239 2841384
SGTC_257 daunorubicin 18.5 µM -1.16711873389574 0.140527775508513 no 2942 0.121581211668029 4272 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_542 3381-0244 89.3 µM -1.16720138064037 0.14051070987316 no 2943 0.12156452674326 4264 1112843
SGTC_2905 7799065 20.05 µM -1.16826699853225 0.140290797623761 no 2944 0.121349541367668 4154 1296806
SGTC_2823 7987624 58.44 µM -1.16946489312885 0.14004386656007 no 2945 0.121108188877183 4261 2239440
SGTC_2606 farnesol 9.78 µM -1.17180678210356 0.139561968754098 no 2946 0.120637319579391 4296 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2182 6325192 200 µM -1.17361546813746 0.13919056246348 no 2947 0.12027454133922 4245 736248
SGTC_2046 4110841 106 µM -1.17373895048501 0.139165230419754 no 2948 0.120249801853428 4245 44119630 YMR134W ERG29
SGTC_802 4112-3352 742 µM -1.17479052274397 0.13894963057218 no 2949 0.120039266337404 4327 704594
SGTC_713 1488-1073 324 µM -1.17538660588813 0.138827518963187 no 2950 0.119920039834896 4265 3312542
SGTC_2086 5274770 176.623 µM -1.17618185858598 0.138664719962301 no 2951 0.119761106137211 4301 689278
SGTC_3071 9117417 49.47 µM -1.17739400247445 0.1384168279582 no 2952 0.119519141290743 4213 45595590 YGL055W OLE1
SGTC_2767 sibutramine 71.45 µM -1.18028391113735 0.137827040170212 no 2953 0.118943657457887 4296 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2895 9054447 58.44 µM -1.18057915738683 0.137766881438036 no 2954 0.11888497376307 4343 2697450
SGTC_602 3130-1533 38.1 µM -1.18566420470393 0.136733574676018 no 2955 0.117877467958557 4319 720941
SGTC_225 nsc-122657 1.016 µM -1.18788949668642 0.136283055290518 no 2956 0.117438474146045 4279 275685
SGTC_3328 9140624 29.0385 µM -1.19170234749654 0.135513491483451 no 2957 0.116688988637228 4285 4904392
SGTC_2539 epi(13)torulosol 80 µM -1.19397094905768 0.135057025570713 no 2958 0.116244666074625 4285 6708597
SGTC_3060 1327-0027 12.5 µM -1.196252495561 0.134599019620286 no 2959 0.115799020336064 4202 16000455 YPR107C YTH1
SGTC_3029 9088683 49.47 µM -1.19860183625056 0.134128519652046 no 2960 0.115341401927445 4313 25236615
SGTC_954 1189-0853 2.85 µM -1.19972988181866 0.133903009119876 no 2961 0.115122131907137 4208 2828194
SGTC_555 4296-0685 37 µM -1.2000230619763 0.133844441396709 no 2962 0.115065191969477 4258 2908540 YHR072W ERG7
SGTC_2770 toltrazuril 17.5 µM -1.20125303161222 0.133598925935419 no 2963 0.114826531861652 4237 68591 Kills coccidiodes.
SGTC_921 1561-0023 372 µM -1.20434825409119 0.132982456358982 no 2964 0.114227501659508 4259 24050882
SGTC_455 paf C-16 10 µM -1.20503503474041 0.1328459374478 no 2965 0.114094888614711 4257 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_415 dibenzyl ketone 100 µM -1.20506505890219 0.132839971418848 no 2966 0.114089093640021 4269 7593
SGTC_1619 st003326 88.7 µM -1.20751193813134 0.132354378053978 no 2967 0.113617525166176 4279 2849032
SGTC_2584 androsterone 48.74 µM -1.20822036570102 0.132214016319243 no 2968 0.113481255061583 4224 2754130 A steroid.
SGTC_444 curcumin 90.4 µM -1.20938671865917 0.131983148815921 no 2969 0.113257154357914 4221 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2064 5220758 200 µM -1.2094423696657 0.131972140228649 no 2970 0.113246469582588 4349 788518
SGTC_1556 plumbagin 1.48 µM -1.20992773279922 0.131876155112454 no 2971 0.113153312246515 4223 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.21213184659974 0.131440876880259 no 2972 0.112730957417393 4310 66535 A nucleotide analog.
SGTC_2890 9046729 58.44 µM -1.21247282590706 0.131373627456763 no 2973 0.112665719243618 4259 903329
SGTC_333 3486-0131 40.1 µM -1.21365758913219 0.131140147989751 no 2974 0.112439252950157 4336 6744690
SGTC_2972 9093619 59.92 µM -1.21425782881129 0.131021969135092 no 2975 0.112324641942223 4246 25236256
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.21429321016221 0.131015005335759 no 2976 0.1123178887601 4286 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_213 1246-0773 967 nM -1.21450478281695 0.130973368692283 no 2977 0.112277512278895 4314 6251622
SGTC_570 0987-0065 62.6 µM -1.2161131020992 0.130657156876359 no 2978 0.111970920057974 4124 3104428
SGTC_1693 xanthone 101.9 µM -1.2164469590482 0.130591583437257 no 2979 0.111907352355575 4339 7020 An insecticide.
SGTC_1613 st002381 52.1 µM -1.21645596625254 0.130589814631476 no 2980 0.11190563770532 4287 551167
SGTC_1293 1000-1278 195 µM -1.21673995399809 0.130534054527337 no 2981 0.111851586207371 4330 678847
SGTC_1383 3049-0032 20.7 µM -1.2169562788374 0.130491590871805 no 2982 0.111810425546697 4357 712864
SGTC_2114 5491910 81.25 µM -1.22105880536918 0.129688090383264 no 2983 0.111031877735486 4346 2849228
SGTC_1229 0139-0193 12.2 µM -1.22159298891882 0.129583720525513 no 2984 0.110930790637156 4373 3090752
SGTC_2412 st077135 33.4 µM -1.22341711753538 0.129227757255961 no 2985 0.110586095655652 4360 13258915
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.22548177433174 0.128825675377105 no 2986 0.11019687647789 4283 364106
SGTC_1037 k284-1091 78.7 µM -1.22646869483588 0.128633784282185 no 2987 0.110011174458537 4290 3334711
SGTC_2757 clomiphene 4.22 µM -1.22762312435516 0.128409575516974 no 2988 0.109794238488513 4329 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1164 k060-0068 93.7 µM -1.22859173555836 0.128221665076751 no 2989 0.109612457818016 4316 5963676
SGTC_2576 guaiol 23.12 µM -1.23070380482155 0.12781258633746 no 2990 0.10921683226847 4219 227829
SGTC_2253 7938677 135.83 µM -1.23125101337594 0.127706747676593 no 2991 0.109114498595118 4367 2301972
SGTC_2294 7971431 200 µM -1.23126582947772 0.12770388285896 no 2992 0.109111728788889 4309 5741572
SGTC_1329 1447-1697 50.6 µM -1.23504521578961 0.126974565425241 no 2993 0.108406838318736 4315 2840515
SGTC_1787 fluconazole 80 µM -1.23684049946827 0.126629142695565 no 2994 0.108073151631462 4049 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_550 4123-0385 25.7 µM -1.23774657240256 0.126455057867316 no 2995 0.107905022278348 4330 5731123
SGTC_859 0439-0102 54.6 µM -1.23774700070342 0.126454975616828 no 2996 0.107904942848135 4339 610143
SGTC_372 0155-0182 15.9 µM -1.23812461353566 0.126382473710947 no 2997 0.107834929328849 4207 771486
SGTC_2208 7283366 200 µM -1.23974259041664 0.1260721490615 no 2998 0.10753530930072 4310 898663
SGTC_2997 9067075 71.4286 µM -1.24173308230379 0.125691106089096 no 2999 0.107167529852429 4305 27209819
SGTC_303 1348-1668 34.2 µM -1.24200120746321 0.125639839939863 no 3000 0.10711805827309 4331 5380509
SGTC_416 estradiol valerate 100 µM -1.24658816165217 0.124765062854827 no 3001 0.106274272344056 4338 13791 A steroid.
SGTC_659 k018-0002 107 µM -1.24797399622771 0.124501609852257 no 3002 0.106020290118845 4290 6797879 YHR007C ERG11
SGTC_765 1319-0117 244 µM -1.24913906255894 0.124280426960729 no 3003 0.105807107727666 4303 3487746 YGL099W LSG1
SGTC_1014 4130-3005 69.3 µM -1.25113528117609 0.123902092508818 no 3004 0.105442562704376 4342 743608
SGTC_122 0236-0016 402.397 µM -1.25378420523492 0.12340129931675 no 3005 0.104960225844251 4318 6808838
SGTC_1253 0550-0034 176 µM -1.25416957051829 0.123328562276999 no 3006 0.104890188812644 4362 5969915
SGTC_1117 retinoic acid 1.10837 µM -1.25446597350381 0.123272637160553 no 3007 0.104836342986144 4367 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3260 9137109 49.47 µM -1.25670268971796 0.122851188028292 no 3008 0.10443065690008 4272 17478346
SGTC_1426 4048-4480 71.7 µM -1.25883513734304 0.122450327326505 no 3009 0.104044942971948 4346 14224343
SGTC_2152 5568786 200 µM -1.26078246786716 0.12208506783455 no 3010 0.103693616046437 4349 5399883
SGTC_2665 lovastatin 100 µM -1.2610491572992 0.122035104702214 no 3011 0.103645568458707 4360 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2206 7254556 146.969 µM -1.26111990571546 0.122021852697243 no 3012 0.103632824918148 4369 4398905
SGTC_473 2-arachidonoylglycerol 10 µM -1.26504155362782 0.121288862342921 no 3013 0.102928216217817 4169 5282280 An endocannabinoid.
SGTC_932 2857-0803 154 µM -1.26509168036194 0.121279513302223 no 3014 0.102919232451779 4362 674898
SGTC_374 0880-0231 82.3 µM -1.26820680366167 0.120699511697338 no 3015 0.102362053997651 4217 6833587
SGTC_1163 k060-0048 49.9 µM -1.26895969882758 0.120559624401703 no 3016 0.10222771912331 4333 6809982
SGTC_1417 3966-0327 90.4 µM -1.2693627152145 0.120484791219243 no 3017 0.102155863878273 4435 651118
SGTC_272 doxorubicin 8.13 µM -1.2713022572153 0.120125109311916 no 3018 0.101810569821542 4358 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3136 9095672 49.47 µM -1.27425853811285 0.119578333156242 no 3019 0.101285902690178 4180 17217380
SGTC_2435 5706476 10.6 µM -1.27508280896322 0.11942619438177 no 3020 0.101139966715008 4338 5725375
SGTC_1123 mangostin 811.285 nM -1.27747459270942 0.118985507135131 no 3021 0.100717372397129 4342 5281650 An antioxidant.
SGTC_3139 9095020 49.47 µM -1.27825408527482 0.118842133681002 no 3022 0.100579925725499 4176 25236292
SGTC_902 1120-0002 2.07 µM -1.27839392613471 0.118816425417372 no 3023 0.100555282293945 4333 3280475
SGTC_1773 st048542 73.5835 µM -1.28039714905495 0.118448585187557 no 3024 0.100202748063521 4315 3237138
SGTC_817 1391-0715 46 µM -1.28215502965482 0.118126459441796 no 3025 0.099894134003792 4330 1353946
SGTC_3168 9103419 49.47 µM -1.28226160304158 0.118106950163113 no 3026 0.0998754462915348 4373 16649256
SGTC_1454 4239-0054 42.6 µM -1.28241019260199 0.118079753225288 no 3027 0.0998493952782069 4428 1340767
SGTC_1658 st012944 20 µM -1.28257464515455 0.11804965798537 no 3028 0.099820568920706 4194 24207260
SGTC_1007 4101-0031 70 µM -1.28321294573783 0.117932898734988 no 3029 0.0997087408578555 4344 1146276
SGTC_3213 9129884 49.47 µM -1.29008579352198 0.116680877301462 no 3030 0.0985104359257242 4333 17190742
SGTC_36 0335-0881 14.2 µM -1.29106464584616 0.116503330122805 no 3031 0.0983406310340083 4263 23828853
SGTC_1411 3909-8223 150 µM -1.2916361468441 0.11639975819435 no 3032 0.0982415899472087 4363 X1411
SGTC_769 0302-0231 76 µM -1.29456924820202 0.115869226258649 no 3033 0.0977344332411845 4268 571869 YER009W NTF2
SGTC_795 0685-0265 78 µM -1.2949174945021 0.115806350567818 no 3034 0.0976743463765181 4367 302754
SGTC_1017 4239-0030 168 µM -1.29716481876977 0.115401179995295 no 3035 0.0972872414271994 4375 1149593
SGTC_2811 7967822 32.47 µM -1.29800371261845 0.115250194162685 no 3036 0.0971430296057857 4395 2232244
SGTC_547 1120-0019 610 nM -1.29828533172332 0.115199539276836 no 3037 0.0970946524683629 4316 3676939
SGTC_191 3914-0123 66.505 µM -1.30043625350096 0.114813174595712 no 3038 0.0967257456350834 4389 3144412
SGTC_2575 plumbagin 510 nM -1.30084040602685 0.114740680693119 no 3039 0.096656544048828 4276 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2104 5389443 200 µM -1.30780692939262 0.113496193219581 no 3040 0.0954694016539993 4405 2244536
SGTC_868 0527-0199 213 µM -1.30866333497997 0.11334387332605 no 3041 0.0953242083495218 4327 2849450
SGTC_2138 5575593 77.673 µM -1.31137051345111 0.11286333496799 no 3042 0.0948663079319677 4380 762213
SGTC_1073 triclabendazole 3.09 µM -1.31241404642272 0.112678491315151 no 3043 0.0946902350263748 4404 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_495 decylubiquinone 155 µM -1.31341752813878 0.112500946038312 no 3044 0.094521147157695 4371 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1473 k844-0725 134 µM -1.31727818083017 0.11181974719417 no 3045 0.0938726980846546 4415 54682906
SGTC_2794 7785382 27.27 µM -1.32103693085168 0.111159367893757 no 3046 0.0932445252682447 4373 2205081
SGTC_229 benomyl 22.8748 µM -1.32464627549178 0.11052787056741 no 3047 0.0926442499492156 4402 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1276 0871-0068 94.2 µM -1.32733357899638 0.110059368248327 no 3048 0.0921991803794184 4408 3414906
SGTC_67 0335-0847 266 µM -1.32865634938851 0.109829281497171 no 3049 0.0919806861054413 4456 4552207 YOR254C SEC63
SGTC_3249 9135183 49.47 µM -1.33196255573699 0.109255700152297 no 3050 0.0914362465698971 4355 4902779
SGTC_1312 1218-2183 165 µM -1.33464237259747 0.108792370388634 no 3051 0.090996711414017 4444 6744073
SGTC_1219 1469-0211 33.1 µM -1.33731936485653 0.108330941278266 no 3052 0.0905592062924307 4395 6822282
SGTC_739 1486-1183 203 µM -1.34020949841026 0.107834356217118 no 3053 0.0900886222187015 4396 4346692
SGTC_200 k038-0079 37.545 µM -1.34177214700862 0.107566544574221 no 3054 0.0898349429278562 4386 3436683
SGTC_2291 7917025 104.35 µM -1.34377966764549 0.107223193191347 no 3055 0.0895098231184755 4290 2964612
SGTC_2101 5377231 179.231 µM -1.34425974203953 0.10714120205365 no 3056 0.0894322044423066 4429 2844213
SGTC_2684 capsaicin 100 µM -1.34767913809355 0.106558516530753 no 3057 0.088880802391706 4428 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1323 1348-1351 11.2 µM -1.34917379800468 0.106304537336591 no 3058 0.0886405743733373 4385 6989654
SGTC_1062 mesoridazine 14.2 µM -1.35180955649601 0.105857723441285 no 3059 0.0882181231078621 4438 4078 A neuroleptic.
SGTC_3118 9124250 49.47 µM -1.35205239870181 0.105816625213942 no 3060 0.0881792767370009 4358 1504786
SGTC_1810 st050138 53 µM -1.35370312503599 0.105537564554427 no 3061 0.0879155553709 4405 3444541
SGTC_1194 1488-0194 225 µM -1.35606948189546 0.105138453138188 no 3062 0.0875385309073229 4379 1391452
SGTC_2891 9063876 19.48 µM -1.35967290905403 0.104532796456958 no 3063 0.0869667273554248 4435 6472478
SGTC_2135 5326629 150.42 µM -1.36219302398833 0.10411072529241 no 3064 0.0865684884018764 4356 5020077
SGTC_2137 5261020 140 µM -1.36348982991919 0.103894017136276 no 3065 0.0863640937499533 4387 763655
SGTC_531 3788-1495 174 µM -1.36629844988648 0.103425792968025 no 3066 0.0859226536792187 4399 2896655
SGTC_425 3825-7017 13.1 µM -1.36647171841241 0.103396957668198 no 3067 0.0858954758936405 4432 3397440
SGTC_1681 tripelennamine 100 µM -1.36844199034131 0.103069475962972 no 3068 0.0855868841052336 4316 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2544 sphondin 68.51 µM -1.36864686763521 0.103035466305658 no 3069 0.0855548431231086 4372 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1908 st060353 56.5 µM -1.37051725493886 0.102725358604985 no 3070 0.0852627464307094 4447 4227716
SGTC_701 4424-0219 185 µM -1.3707866623107 0.102680747171955 no 3071 0.0852207349596632 4432 2911779
SGTC_2978 9011784 42.97 µM -1.37121686867723 0.102609538073368 no 3072 0.085153680604015 4400 2994934
SGTC_711 k292-0785 179 µM -1.37128683985014 0.102597959621646 no 3073 0.0851427782472296 4350 4146315
SGTC_1897 st060201 15 µM -1.37286987338976 0.102336261537104 no 3074 0.0848964018842398 4430 611878
SGTC_1171 0368-0077 21.4 µM -1.37691034990208 0.101670514505523 no 3075 0.0842699834485257 4402 3239779
SGTC_326 k292-0812 17.5 µM -1.37788715449099 0.101510041351964 no 3076 0.0841190657776904 4397 3579357
SGTC_68 0986-0284 82.829 µM -1.37944158057089 0.101255054833135 no 3077 0.0838793232576289 4431 423278 YIL048W NEO1
SGTC_2408 sulbentine 18.36 µM -1.3796896946617 0.101214397672529 no 3078 0.083841103619188 4302 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_479 n-linoleoylglycine 10 µM -1.38016473950227 0.101136587749277 no 3079 0.0837679639336072 4459 6433346 An anti-infammatory.
SGTC_1061 3448-9325 110 µM -1.38213237446217 0.100814763401279 no 3080 0.083465529798818 4379 723482
SGTC_2586 curcumin 80 µM -1.38281380930538 0.100703482893729 no 3081 0.0833609818090528 4322 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_83 0170-0301 39.027 µM -1.38653825594732 0.100096851400459 no 3082 0.0827913035711096 4440 3089716
SGTC_618 k072-0232 33.2 µM -1.39031537532208 0.0994843700025545 no 3083 0.0822165654847682 4467 5872756 YGL099W LSG1
SGTC_3179 9107801 49.47 µM -1.39775174037885 0.098286534864292 no 3084 0.0810938154971392 4422 4818259
SGTC_1375 2910-0797 186 µM -1.40013054705204 0.0979056003791023 no 3085 0.0807371145406848 4421 742508
SGTC_3000 9075062 71.4286 µM -1.40173134413722 0.097649863663453 no 3086 0.0804977435107103 4412 17057871
SGTC_2739 tacrine 100.86 µM -1.40284308078315 0.0974725456462959 no 3087 0.0803318185867081 4495 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2844 9010103 25.97 µM -1.40518327807828 0.0971000645549821 no 3088 0.0799833926444385 4424 2480525
SGTC_1962 st076595 64.5 µM -1.40650207233957 0.0968906174377088 no 3089 0.0797875448333543 4408 279619
SGTC_2938 9059746 27.26 µM -1.40851675102267 0.096571292675936 no 3090 0.0794890551830396 4436 6471769
SGTC_2839 9003951 25.97 µM -1.41016762210307 0.0963102079433093 no 3091 0.0792450969012314 4481 2990634
SGTC_3166 9102297 49.47 µM -1.4115639511195 0.0960897842205198 no 3092 0.0790391965429661 4455 25237072
SGTC_3057 9095946 49.47 µM -1.41330574323835 0.0958153460852562 no 3093 0.0787829230235477 4498 24540043
SGTC_545 4218-0007 221 µM -1.41529450603302 0.0955027005471264 no 3094 0.078491082580933 4435 2840508
SGTC_1209 2323-2347 50.3 µM -1.4162965631629 0.0953454558636623 no 3095 0.0783443468372835 4458 5412760
SGTC_2313 7726885 200 µM -1.42431855743842 0.0940934949609257 no 3096 0.0771771389621045 4467 726423
SGTC_298 1391-0729 10 µM -1.42439601236947 0.094081466281061 no 3097 0.0771659339536487 4389 3237558
SGTC_1680 diphenhydramine 100 µM -1.42561525081686 0.0938922691356437 no 3098 0.0769897158020941 4416 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2876 9059903 25.97 µM -1.42794136119764 0.0935320906768393 no 3099 0.0766543686332253 4449 6916095
SGTC_165 k038-0023 64.381 µM -1.43327221891257 0.092710503297485 no 3100 0.0758900289984186 4438 46368543
SGTC_1362 1611-0397 101 µM -1.43572019385868 0.0923350166854465 no 3101 0.075540988325406 4436 27816
SGTC_869 0564-0080 44.1 µM -1.43900339639319 0.0918331858887579 no 3102 0.0750747802314336 4460 6843321
SGTC_381 3461-2219 42.7 µM -1.44560348814014 0.0908304928917961 no 3103 0.0741442238688024 4436 2883159
SGTC_3147 9097027 49.47 µM -1.44674451881115 0.0906579730288926 no 3104 0.0739842454166448 4475 25236841
SGTC_2973 9094665 17.96 µM -1.4500701545224 0.0901565360622456 no 3105 0.0735194784223587 4456 25237061 YIL048W NEO1
SGTC_2949 9072542 2.23 µM -1.45109944737611 0.0900017583177751 no 3106 0.0733760851977562 4447 16457352
SGTC_3082 9117008 49.47 µM -1.45133578769896 0.0899662470292092 no 3107 0.0733431902857713 4493 41448529
SGTC_648 0375-0473 33.3 µM -1.45672984923096 0.0891585911829017 no 3108 0.072595483420272 4450 1713139
SGTC_833 3852-0053 558 µM -1.45803759451572 0.0889635968719354 no 3109 0.0724150904450023 4533 3123681
SGTC_2678 equilin 100 µM -1.46002726559009 0.0886675316781605 no 3110 0.0721412902974362 4471 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_216 k038-0035 28.382 µM -1.46051676082656 0.0885948068645009 no 3111 0.0720740522659408 4405 4444231 YPR107C YTH1
SGTC_428 3448-4153 16.5 µM -1.46068281586671 0.0885701459911976 no 3112 0.0720512535344544 4422 3834874
SGTC_2719 novobiocin 32.65 µM -1.46639705600279 0.0877246354079689 no 3113 0.0712700739569272 4510 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_933 2914-0560 114 µM -1.4684665955267 0.0874199048443121 no 3114 0.070988761780653 4492 463887
SGTC_2745 rifampicin 24.3 µM -1.47284005545528 0.0867785324183529 no 3115 0.0703970844053812 4575 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_62 0180-0423 3.232 µM -1.47427702312078 0.0865685689300626 no 3116 0.0702035094957074 4440 30102 YGL099W LSG1
SGTC_1970 st070122 35.8 µM -1.47464507594784 0.0865148517850222 no 3117 0.0701539947627992 4493 102928
SGTC_386 1509-0011 3.07 µM -1.47603155732849 0.0863127191844546 no 3118 0.0699677103843125 4487 3107280
SGTC_2514 salinomycin 42.74 µM -1.47776965156226 0.0860598247313524 no 3119 0.0697347220367641 4516 23682228 A polyether potassium ionophore.
SGTC_33 0986-0033 35.816 µM -1.48339164663127 0.0852456154160727 no 3120 0.0689851927574633 4463 2848082
SGTC_2421 5690543 90.72 µM -1.48402273623371 0.0851545789430633 no 3121 0.0689014444614036 4477 3397993
SGTC_1686 st019653 115.5 µM -1.48415682001116 0.0851352463632265 no 3122 0.0688836610684373 4484 97252
SGTC_115 0527-0192 112.043 µM -1.48673864936423 0.0847636320071748 no 3123 0.0685419253128638 4461 4233931
SGTC_2029 5175081 200 µM -1.4868052678214 0.084754059435013 no 3124 0.0685331249081343 4448 1380876
SGTC_1975 st070967 30.8 µM -1.48727577681254 0.0846864739055294 no 3125 0.0684709947326178 4473 261391
SGTC_332 4112-0506 40.9 µM -1.48863476589659 0.0844914910154391 no 3126 0.0682917857729889 4471 2790355
SGTC_1035 k081-0041 55.2 µM -1.49235624353078 0.0839592708427425 no 3127 0.0678028897529922 4502 731709
SGTC_474 dl-dihydrosphingosine 5 µM -1.49601862834972 0.0834379634035543 no 3128 0.0673244004224719 4482 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_387 norethindrone acetate 66.7 µM -1.50018287022668 0.0828481810592562 no 3129 0.0667835196050639 4504 541197
SGTC_3261 9137475 49.47 µM -1.50205019055497 0.0825847329808474 no 3130 0.066542073584056 4513 17027690
SGTC_3149 9097855 49.47 µM -1.50320763186026 0.0824217539708608 no 3131 0.0663927550567813 4484 25236625 YMR079W SEC14
SGTC_1301 naphtanilide LB 4.81 µM -1.5052876915257 0.082129470142743 no 3132 0.0661250641349632 4546 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2469 5655019 90.81 µM -1.51338927778508 0.0809984993288086 no 3133 0.0650904034746515 4563 2788239
SGTC_1766 st045414 44.774 µM -1.51464698788222 0.0808239838469102 no 3134 0.0649309130220768 4512 253960
SGTC_1745 st081495 74 µM -1.5162794042013 0.0805978989741155 no 3135 0.0647243586125772 4366 13842402 YBL026W LSM2
SGTC_2825 7998094 58.44 µM -1.522295518402 0.0797688078878511 no 3136 0.0639675252557294 4480 2987815
SGTC_1410 3909-8106 77.9 µM -1.5249655418231 0.0794029208966833 no 3137 0.0636338462779261 4560 1039210
SGTC_2320 7373003 200 µM -1.53516932902318 0.0780163405856242 no 3138 0.0623711200560085 4497 5415828
SGTC_929 2805-0021 398 µM -1.54081636291779 0.0772569101467384 no 3139 0.0616807429382274 4537 3098024
SGTC_2899 9053889 58.44 µM -1.54822411152602 0.0762692257956302 no 3140 0.0607841740837652 4515 6470052
SGTC_2788 5282734 71.43 µM -1.55097569425512 0.0759048115297635 no 3141 0.0604537544241692 4538 743706
SGTC_1950 st077106 7.18 µM -1.55249799345603 0.0757037716848802 no 3142 0.060271556227072 4429 13831864
SGTC_1754 st042065 16.137 µM -1.55587797644815 0.0752588504137674 no 3143 0.0598685556673428 4265 1126236 YIL048W NEO1
SGTC_2132 5317594 122.667 µM -1.55802831972723 0.0749768310440862 no 3144 0.0596132675034616 4464 794577
SGTC_2868 9035608 32.47 µM -1.5584491619384 0.0749217316628101 no 3145 0.0595634051908701 4517 6462614
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.56495398190987 0.0740740021263031 no 3146 0.0587968499084376 4529 6708561
SGTC_346 4513-0042 7.16 µM -1.56953772584394 0.073481048394048 no 3147 0.0582613480531607 4470 2827372
SGTC_314 1671-0008 2.74 µM -1.5700617356798 0.0734134942649711 no 3148 0.0582003747362319 4404 3913060
SGTC_1248 0469-0687 58.6 µM -1.57160983463369 0.0732141943948879 no 3149 0.0580205321302453 4487 4017482
SGTC_2429 5902844 64.44 µM -1.57166648917681 0.0732069086359009 no 3150 0.0580139588670419 4512 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3353 9151644 39.2805 µM -1.5719909340413 0.0731651957976483 no 3151 0.057976326882689 4538 4909158
SGTC_2344 7990960 76.95 µM -1.58086703340239 0.0720310651459654 no 3152 0.0569542217346984 4519 140813
SGTC_529 4076-0302 30.3 µM -1.5811263902307 0.0719981300285365 no 3153 0.0569245708785969 4500 5816522
SGTC_2305 7443522 69.23 µM -1.58164217551592 0.0719326659750056 no 3154 0.0568656400756999 4433 5415886
SGTC_3210 9128157 49.47 µM -1.58256890505011 0.0718151590999505 no 3155 0.0567598777560887 4482 17590849
SGTC_2372 9071633 200 µM -1.58523594843289 0.0714778064768997 no 3156 0.0564563678480788 4582 21321366
SGTC_1367 1812-0510 76.9 µM -1.58640174761761 0.0713307278090953 no 3157 0.0563241021227853 4590 1142582 YDR527W RBA50
SGTC_1451 4152-0210 104 µM -1.59367890735437 0.0704178781157597 no 3158 0.0555039854316606 4569 659563
SGTC_740 k014-0057 261 µM -1.59825715403916 0.0698482005728722 no 3159 0.0549928793195927 4527 4012779
SGTC_2627 acetyl isogambogic acid 100 µM -1.5986566201028 0.0697986631858967 no 3160 0.054948460729315 4549 6857789 A caspase activator and apoptosis inducer.
SGTC_2551 apiole 73.87 µM -1.59878521673824 0.0697827218007004 no 3161 0.0549341674731549 4486 10659 A possible DNA adduct former.
SGTC_2220 6782180 200 µM -1.60075047511308 0.0695394485412031 no 3162 0.0547160983390537 4500 833803
SGTC_112 phenothiazine 287.218 µM -1.6068604212234 0.0687872874794213 no 3163 0.0540424951570997 4512 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3236 9132701 49.47 µM -1.60702568189794 0.0687670306427996 no 3164 0.0540243672504264 4559 24282524
SGTC_1270 0831-1170 17.3 µM -1.60821073865868 0.0686219069679537 no 3165 0.0538945160274707 4559 6764716
SGTC_1470 k295-0292 231 µM -1.61659623044229 0.0676017484154822 no 3166 0.0529827330681753 4606 5045612
SGTC_2366 9070441 60.58 µM -1.62221243272005 0.0669250739905134 no 3167 0.0523789352717788 4524 6837235
SGTC_1968 st069590 43.6 µM -1.62814541850059 0.0662159352627912 no 3168 0.0517470274869797 4514 6384066
SGTC_3090 9117696 49.47 µM -1.62829817288059 0.0661977544807802 no 3169 0.0517308383634068 4522 7923821
SGTC_348 k064-0012 10.7 µM -1.62857285306386 0.0661650718526565 no 3170 0.0517017375009043 4513 5066323
SGTC_1990 st072050 59.8 µM -1.63253878025276 0.0656945806352149 no 3171 0.0512830179491322 4554 17233948
SGTC_1084 voriconazole 435 nM -1.6390344741329 0.064929582940172 no 3172 0.0506030400988689 4581 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_572 0960-0087 17.7 µM -1.64099784479147 0.0646997230181172 no 3173 0.050398931288565 4519 6796365
SGTC_2218 6965428 192.983 µM -1.64133808379067 0.064659954155361 no 3174 0.0503636273814501 4475 675684
SGTC_451 chloral hydrate 100 µM -1.64372810983673 0.0643811306379722 no 3175 0.0501161884211238 4545 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2067 5224629 34.075 µM -1.64564235270923 0.0641584871290963 no 3176 0.0499187070159818 4535 2835000
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.64782612400486 0.0639052264313902 no 3177 0.0496941783034897 4590 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1786 berberine 21.6 µM -1.65018264880162 0.0636328037187707 no 3178 0.0494527922821341 4474 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.65497258271859 0.0630818559479516 no 3179 0.0489650297720092 4640 688664
SGTC_98 0074-0023 107.663 µM -1.66180681672537 0.0623022094759158 no 3180 0.0482757575098049 4563 3563821
SGTC_304 1310-0298 97 µM -1.66386735477107 0.0620686246210044 no 3181 0.0480694700551433 4317 1550234
SGTC_2340 7987427 183.45 µM -1.6652619998093 0.0619109142701519 no 3182 0.0479302481587991 4565 2239331
SGTC_3356 9151811 4.48 µM -1.67126952941679 0.0612351386589141 no 3183 0.0473342260787144 4602 1859254 YPR165W RHO1
SGTC_2389 9091542 195.52 µM -1.6743812545498 0.0608873797623537 no 3184 0.047027847245636 4549 3626624 YOL127W RPL25
SGTC_2968 9090663 33.37 µM -1.6750782026728 0.0608097025832207 no 3185 0.0469594445215001 4521 25236811
SGTC_2239 6685329 187.64 µM -1.68314831131053 0.0599158958148503 no 3186 0.046173192041545 4578 805680
SGTC_3063 1327-0034 4 µM -1.68525531364814 0.0596842365147854 no 3187 0.0459696616257285 4462 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_917 harmaline 728.087 nM -1.69143039704794 0.0590093437413264 no 3188 0.0453773154171464 4509 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1834 st055981 52.8 µM -1.69665034325815 0.0584435228423696 no 3189 0.0448813929600494 4575 471719 YDL150W RPC53
SGTC_484 loperamide 105 µM -1.70233516702189 0.0578321671039892 no 3190 0.0443462779999286 4690 3955 An opioid-receptor agonist.
SGTC_1952 st077036 64.1 µM -1.70395266902506 0.0576591400563261 no 3191 0.0441949650306532 4607 2937007
SGTC_2957 9076800 11.52 µM -1.70417032736764 0.0576358878676796 no 3192 0.044174635485113 4571 16459615
SGTC_876 0720-0963 56.8 µM -1.70477730979546 0.0575710835934209 no 3193 0.044117982434379 4598 765861
SGTC_1587 estradiol valerate 56.1 µM -1.70820068404423 0.0572066606782092 no 3194 0.0437995558263827 4638 13791 A steroid.
SGTC_1877 wortmannin 25 µM -1.70844159022371 0.0571810844141636 no 3195 0.0437772178439305 4613 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2703 st077852 53.4 µM -1.72505075367552 0.055439339494039 no 3196 0.042259163167469 4613 6281836
SGTC_116 0155-0182 31.788 µM -1.7265294682181 0.0552863249171118 no 3197 0.0421261012811646 4458 771486
SGTC_745 0469-0705 296 µM -1.73342054404702 0.0545776438419371 no 3198 0.0415104743528361 4630 3486736
SGTC_2453 5731132 22.18 µM -1.73985223265405 0.0539227058891521 no 3199 0.0409424840390705 4628 1362040
SGTC_338 4055-0136 114 µM -1.74085363584571 0.0538212953034418 no 3200 0.0408546187469071 4592 2900563
SGTC_1196 1588-0294 184 µM -1.75599917171976 0.0523058726466145 no 3201 0.0395442749950064 4643 6144269
SGTC_585 0kpi-0023 191 µM -1.75864379566281 0.0520447670258673 no 3202 0.0393190146472428 4558 64601
SGTC_2296 7971656 126.45 µM -1.76482146450791 0.0514388755331194 no 3203 0.0387968880135244 4606 666570
SGTC_1004 4084-0029 199 µM -1.77442090775211 0.0505085302589846 no 3204 0.0379967770198388 4618 716894 YLR208W SEC13
SGTC_1740 st038286 13.222 µM -1.78194637784457 0.0497886021106133 no 3205 0.0373789882559939 4610 716786
SGTC_1169 aniline yellow 25.8 µM -1.78241496568365 0.0497440465285651 no 3206 0.0373407933908051 4578 6051 A DNA damaging agent.
SGTC_82 0054-0107 293.755 µM -1.78303429389735 0.0496852066401325 no 3207 0.0372903605123295 4609 3104697
SGTC_2881 9058953 51.95 µM -1.78309318073725 0.0496796149300389 no 3208 0.0372855681620454 4592 17122249
SGTC_339 3091-4833 71.4 µM -1.7835076107819 0.0496402761500346 no 3209 0.0372518550945564 4448 3240077
SGTC_2063 5246145 200 µM -1.79163395107971 0.0488739133658888 no 3210 0.036595810469608 4637 711240
SGTC_3280 9140961 49.47 µM -1.7934607126078 0.0487029469957447 no 3211 0.0364496436122963 4642 4901226
SGTC_1150 3909-7983 10.9 µM -1.80145044663934 0.0479607993532107 no 3212 0.0358159555166942 4633 23965914
SGTC_1059 3448-6867 171 µM -1.80261015161946 0.0478538333864737 no 3213 0.0357247307962817 4589 3934407
SGTC_97 0535-0701 19.132 µM -1.80272943106374 0.0478428424284279 no 3214 0.0357153588452904 4545 2832013 YGL099W LSG1
SGTC_1987 st072290 61.9 µM -1.80870547744895 0.0472947642749472 no 3215 0.0352483857906864 4640 54697379
SGTC_2490 carminic acid 95.39 µM -1.81329741698488 0.0468770541277627 no 3216 0.0348929807426445 4626 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_683 panaxydol 45 µM -1.81800457762907 0.0464519393328561 no 3217 0.03453171656503 4648 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1875 nocodazole 6 µM -1.8200353140507 0.0462694968072872 no 3218 0.0343768136048715 4655 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2913 7966556 36.57 µM -1.82524475493269 0.0458041080603202 no 3219 0.0339820514052079 4541 2976516
SGTC_1437 4092-1038 11.6 µM -1.82529662437523 0.0457994932559268 no 3220 0.0339781396555264 4683 3977136
SGTC_3131 9127911 49.47 µM -1.83048194636751 0.0453400397611688 no 3221 0.0335889519777873 4620 45595681
SGTC_2769 toremifene 3.73 µM -1.8371155908306 0.0447576688176624 no 3222 0.0330964165157289 4628 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1920 st075728 45.7 µM -1.83845501790958 0.044640813919368 no 3223 0.0329976921798124 4612 3400306
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.83894593584841 0.0445980466216787 no 3224 0.0329615692170038 4629 688667
SGTC_2216 7189485 200 µM -1.84791325727731 0.0438226321034753 no 3225 0.0323074461828168 4677 731273
SGTC_1703 st026983 48.3 µM -1.87258232601581 0.0417454658629734 no 3226 0.0305630418992566 4663 1104023
SGTC_2155 5570423 76 µM -1.88700980928629 0.0405680815729696 no 3227 0.0295795031467496 4646 797402
SGTC_1937 st074714 47.2 µM -1.88912500098753 0.0403977548950585 no 3228 0.0294375405800577 4601 17250970
SGTC_2487 5918373 44.05 µM -1.89293397765329 0.0400925000979826 no 3229 0.0291833250121444 4677 2876279
SGTC_1158 4092-0494 91.8 µM -1.8949977679802 0.039927890492515 no 3230 0.029046348687529 4695 1148199
SGTC_3323 9138564 53.9225 µM -1.89956955611391 0.0395651968101136 no 3231 0.028744815294133 4678 43912313 YNL103W MET4
SGTC_3258 9138477 49.47 µM -1.91283343009413 0.0385280756191127 no 3232 0.0278846899890152 4696 4970355
SGTC_536 3852-0578 10.6 µM -1.91364140136778 0.0384656219361122 no 3233 0.0278329955951291 4659 2869208
SGTC_504 lovastatin 124 µM -1.9151867650752 0.0383463999431426 no 3234 0.0277343448622111 4654 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2635 hydroquinidine 100 µM -1.9225658808084 0.0377812616660099 no 3235 0.027267296191772 4616 442912 An experimental heart treatment.
SGTC_2898 9056270 58.44 µM -1.92730566732964 0.0374218583341646 no 3236 0.026970773867571 4680 19154699
SGTC_1414 3917-0015 5.4 µM -1.92782054393146 0.0373829855406015 no 3237 0.0269387257323726 4673 6618702
SGTC_1999 st074831 12.5 µM -1.92881663974559 0.0373078746908709 no 3238 0.0268768146787966 4647 17112523
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.93269509426736 0.0370165926044526 no 3239 0.0266368849457156 4663 689007
SGTC_410 α-linolenic acid 100 µM -1.94669008963388 0.0359809507876842 no 3240 0.0257859502348006 4688 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3045 9092950 49.47 µM -1.94912866771184 0.0358029451135571 no 3241 0.0256400304460093 4647 44120432
SGTC_3300 9124615 50.48 µM -1.96199555644676 0.0348756287629556 no 3242 0.0248815007967821 4658 24824903
SGTC_738 1315-0003 72.4 µM -1.97128440872813 0.0342185107364521 no 3243 0.0243456768516671 4672 6251474
SGTC_3165 9101544 49.47 µM -1.98601175210202 0.0331975453965337 no 3244 0.023516009502971 4687 5002184
SGTC_778 3456-2434 196 µM -1.99281077489666 0.0327347446325642 no 3245 0.0231410857236204 4602 5539063
SGTC_2651 TUB2.036 5 µM -1.99809042538738 0.0323790461569752 no 3246 0.0228534287918991 4564 15992207 YFL037W TUB2
SGTC_3266 9136860 49.47 µM -1.99961235109972 0.0322771057791064 no 3247 0.0227710696018587 4442 4871271 YPR165W RHO1
SGTC_1867 st057372 64 µM -2.01245226408266 0.0314275747459763 no 3248 0.0220861419389633 4676 688837
SGTC_1906 st060206 94.7 µM -2.01877432414666 0.0310161275605182 no 3249 0.0217553404431116 4692 5133468
SGTC_2117 5521686 200 µM -2.02494888690261 0.0306185922111434 no 3250 0.0214363064857932 4686 803312
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.03230899692754 0.0301502503309117 no 3251 0.0210611921154111 4679 688669
SGTC_2162 5663267 200 µM -2.05525451960394 0.0287281399554046 no 3252 0.019927213838322 4699 6456493
SGTC_2860 9025725 38.96 µM -2.05812616224063 0.0285541543977282 no 3253 0.0197890120999827 4724 40546248
SGTC_2297 7971671 152.32 µM -2.06024753313707 0.0284261895667473 no 3254 0.019687441446935 4665 909016
SGTC_1871 st057448 67.3 µM -2.07111483260483 0.0277781158697831 no 3255 0.0191740330219244 4692 691747
SGTC_2871 9038510 12.99 µM -2.07163086300048 0.0277476509951125 no 3256 0.0191499397064443 4667 4945164
SGTC_2112 5488546 200 µM -2.08094025948536 0.0272028168447806 no 3257 0.0187196872688653 4682 600757
SGTC_2464 5717415 7.67 µM -2.08651770362323 0.0268806921834106 no 3258 0.0184658766294654 4668 5285744
SGTC_768 0384-0033 77.3 µM -2.09041525412308 0.0266574849331642 no 3259 0.0182902568989009 4678 3965305 YMR134W ERG29
SGTC_1755 st041960 45.185 µM -2.0942563778315 0.0264390259453002 no 3260 0.0181185739946944 4720 2257073
SGTC_776 4476-4378 112 µM -2.0965702420235 0.0263081514115467 no 3261 0.0180158179203001 4726 2892008
SGTC_1476 4112-3294 3.34 µM -2.10141471596311 0.026035896286211 no 3262 0.0178022886279004 4700 704369
SGTC_700 3453-2283 142 µM -2.10351353397417 0.0259186783664213 no 3263 0.0177104517433368 4727 565664
SGTC_1464 k208-0027 110 µM -2.1092829977951 0.0255987297992381 no 3264 0.0174600807387342 4702 X1464
SGTC_1636 st007707 68.9 µM -2.11172755721922 0.0254641663601362 no 3265 0.0173549119832885 4708 403051
SGTC_3142 9086498 49.47 µM -2.1190835687096 0.0250628153647281 no 3266 0.0170417025441841 4595 25236367
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.1197193499436 0.0250283768844416 no 3267 0.0170148600889343 4664 17037758
SGTC_665 3914-0008 307 µM -2.13216587556902 0.0243621334671975 no 3268 0.0164966063398165 4700 1069549
SGTC_2755 lomerizine 42.69 µM -2.15254775183975 0.0233033024865018 no 3269 0.0156771192801677 4664 3949 A calcium channel blocker.
SGTC_1224 0823-0416 294 µM -2.15945157778115 0.0229535486404447 no 3270 0.0154075750608415 4730 3598164
SGTC_1348 1493-0373 93.8 µM -2.17304011921088 0.0222780487294649 no 3271 0.0148886489458049 4733 3010129
SGTC_2621 lithochol-11-enic acid 100 µM -2.17600300488446 0.0221330092944004 no 3272 0.0147775179352221 4664 6708711
SGTC_1643 st009866 20.2 µM -2.18485494510847 0.0217044272098981 no 3273 0.0144497419462091 4720 3156273 YOR207C RET1
SGTC_786 4544-0069 423 µM -2.18598477532647 0.0216502324327741 no 3274 0.0144083596014087 4696 748821 YLR208W SEC13
SGTC_2709 st078560 56 µM -2.19745251158529 0.021106598392724 no 3275 0.0139940722446941 4699 17250903
SGTC_975 1335-0046 28.5 µM -2.20320919996639 0.0208380822235805 no 3276 0.0137900035882992 4726 16486740
SGTC_1547 harmine 94.2 µM -2.20754243394593 0.020637874748952 no 3277 0.0136380929165347 4655 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_871 0574-0004 149 µM -2.21026517310237 0.0205129119792535 no 3278 0.0135433820866277 4698 9551173
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.21314658046017 0.0203813657868717 no 3279 0.0134437707987734 4710 688798
SGTC_173 1273-0061 2.693 µM -2.21910219996 0.0201117361983751 no 3280 0.0132398862090197 4682 2847414 YPL266W DIM1
SGTC_1590 st077108 57.8 µM -2.2227574946024 0.0199477523685702 no 3281 0.0131160783369438 4736 5489485
SGTC_673 1082-0474 110 µM -2.22489572475356 0.0198523540207388 no 3282 0.0130441195496012 4710 3098046
SGTC_453 enantio-paf c16 10 µM -2.22637646919276 0.0197865169108779 no 3283 0.0129944876358286 4281 13871343 A lipid and platelet activating factor
SGTC_2347 9049783 174.81 µM -2.2660617818833 0.0180898269694215 no 3284 0.0117238004005744 4707 6467988 YPL169C MEX67
SGTC_2848 9016370 25.97 µM -2.2662888217718 0.0180804887162513 no 3285 0.0117168526916874 4687 7894410
SGTC_1448 4255-0083 152 µM -2.2811063162831 0.0174798603205148 no 3286 0.0112710782370281 4745 5399660
SGTC_1068 loratadine 26.9 µM -2.28200492268185 0.017443989664248 no 3287 0.0112445248130356 4749 3957 A H1 histamine antagonist.
SGTC_609 0986-0026 86.3 µM -2.28378464184749 0.0173731321528688 no 3288 0.0111920953561387 4726 2848610
SGTC_1365 1672-3266 55.4 µM -2.29544180322892 0.0169150667266533 no 3289 0.0108539089931273 4739 6415873
SGTC_439 amiodarone 34.4 µM -2.30154655367951 0.0166793297156709 no 3290 0.0106803785787632 4642 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3231 9132313 49.47 µM -2.30668499093229 0.0164830914527834 no 3291 0.010536193789314 4746 4905967
SGTC_2178 5812956 200 µM -2.30705982892465 0.0164688539609024 no 3292 0.0105257425010831 4722 5403383
SGTC_2151 5563267 85.4165 µM -2.31863041603845 0.016034516962175 no 3293 0.010207542216294 4767 5310824
SGTC_3244 9134489 49.47 µM -2.34546331907061 0.0150648930711815 no 3294 0.00950172418772576 4739 16584271
SGTC_1204 4049-0315 18.3 µM -2.35301221822607 0.0148013621468176 no 3295 0.00931101109353392 4721 588402
SGTC_3059 1327-0034 3 µM -2.35961585998154 0.0145740907281781 no 3296 0.00914693367680184 4647 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_61 0978-8327 98.565 µM -2.36695441779388 0.0143250556689968 no 3297 0.00896757079065236 4706 6150059 YHR072W ERG7
SGTC_1034 k072-0165 12.7 µM -2.39741647130298 0.0133301115116911 no 3298 0.00825557251289835 4754 5835461
SGTC_3250 9135583 49.47 µM -2.40139854221209 0.0132045676403843 no 3299 0.00816626874238408 4769 7699353
SGTC_743 1275-0778 158 µM -2.4094112412721 0.0129550421811581 no 3300 0.00798914105540482 4750 2849257 YMR203W TOM40
SGTC_1339 1486-1321 22.7 µM -2.43813401111273 0.012093788711094 no 3301 0.00738164990391831 4763 3469382
SGTC_2131 toluylene red 5.2905 µM -2.44397708766175 0.0119247925531513 no 3302 0.00726317452492651 4721 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_792 4534-1957 155 µM -2.47026049292599 0.0111897003395946 no 3303 0.00675073478651898 4743 1717904
SGTC_248 streptozotocin 5.23457 mM -2.48287666838193 0.0108510697205838 no 3304 0.0065163100509009 4772 5300 DNA alkylating agent.
SGTC_266 formosanin C 406 nM -2.4918084312831 0.0106167576885202 no 3305 0.0063547282865207 4677 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1765 st044815 90.4 µM -2.49739571339382 0.0104724346731572 no 3306 0.00625546291808868 4764 645695
SGTC_2639 lactacystin 53 µM -2.52927870830219 0.00968115490097958 no 3307 0.00571486123617137 4757 3870 A proteasome inhibitor.
SGTC_336 4111-0029 111 µM -2.54269117356786 0.00936421495474048 no 3308 0.00550012034087971 4776 3131175
SGTC_972 1319-0219 195 µM -2.54859599737009 0.00922758483940149 no 3309 0.00540787574630422 4762 23903702
SGTC_193 1273-0060 1.558 µM -2.58825935359485 0.00835422842815014 no 3310 0.00482311607932335 4708 2847393 YHR072W ERG7
SGTC_431 k089-0097 107 µM -2.59292935546237 0.0082563333410857 no 3311 0.0047581157814688 4526 5499420
SGTC_663 1486-0733 13.9 µM -2.59752403460215 0.00816100197621898 no 3312 0.00469492743350109 4770 722445 YPR165W RHO1
SGTC_2290 7904846 200 µM -2.61103601755431 0.00788623409274846 no 3313 0.00451341930772956 4772 2962154
SGTC_2343 7990716 14.84 µM -2.61281524690624 0.00785066638508006 no 3314 0.0044899915843294 4756 6456862
SGTC_2330 7979373 200 µM -2.61311608065686 0.00784466653136511 no 3315 0.00448604115407802 4738 1863007
SGTC_1829 berberine 14.4 µM -2.62485171115111 0.00761373628273691 no 3316 0.00433433558453213 4728 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1040 k898-0338 155 µM -2.64149537462311 0.00729649653957449 no 3317 0.00412704671020175 4758 20969351
SGTC_2482 5981709 142.65 µM -2.64343467294046 0.00726030099921582 no 3318 0.00410348004557011 4746 877755
SGTC_2695 st077686 51.995 µM -2.68532476382542 0.00651616609793154 no 3319 0.00362296802067706 4749 2876092
SGTC_3209 9113616 49.47 µM -2.6877824474729 0.00647468176847561 no 3320 0.00359641210668237 4766 16649353
SGTC_2226 7298446 200 µM -2.69534705901422 0.00634845789399636 no 3321 0.00351576747650529 4776 3283010
SGTC_1147 3809-1045 12.3 µM -2.69721611280854 0.00631760822043996 no 3322 0.00349609377541954 4778 325925
SGTC_2832 7992762 51.95 µM -2.70248059653285 0.00623142742099988 no 3323 0.00344121006877679 4715 2985177
SGTC_3347 9188721 44.724 µM -2.72044268985459 0.00594516804933978 no 3324 0.00325972858625002 4772 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3143 9086658 49.47 µM -2.73402696646177 0.00573648397871497 no 3325 0.00312824601138356 4734 25236626
SGTC_3271 9137798 49.47 µM -2.74087068655788 0.00563383302969219 no 3326 0.00306383092690149 4784 6498326
SGTC_327 1273-0057 3.96 µM -2.77797966334464 0.00510512197072157 no 3327 0.00273490207662991 4761 3108138
SGTC_1569 carminic acid 40.6 µM -2.78654338045643 0.00498957010579535 no 3328 0.00266367435481642 4786 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1178 0988-0033 191 µM -2.79533918915454 0.00487331747726106 no 3329 0.00259226439678764 4792 5392207
SGTC_153 4077-0274 519.67 µM -2.80106428611977 0.00479895289929092 no 3330 0.00254671856652365 4772 3121976
SGTC_865 0488-0499 301 µM -2.84203841921413 0.00429561439157301 no 3331 0.00224130446678317 4764 9634651
SGTC_514 4466-0038 2.65 nM -2.85729614350638 0.00412059604669847 no 3332 0.00213633496047883 4688 5722064
SGTC_2686 alizarin 95.37 µM -2.86945656682448 0.00398570523443282 no 3333 0.00205588899572145 4774 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2996 9066192 71.4286 µM -2.89123016571608 0.00375402591591231 no 3334 0.00191868482814926 4761 6472854
SGTC_55 0767-0285 6.563 µM -2.92810593463484 0.00338907341136126 no 3335 0.00170516914394694 4776 3116166
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.94102773515971 0.00326893958218155 no 3336 0.00163562621151412 4764 5379071
SGTC_1192 1488-0095 21.4 µM -2.97438212176585 0.00297635073559256 no 3337 0.0014678961465973 4797 915875
SGTC_1959 st077091 55.8 µM -2.97920561819228 0.00293605045740898 no 3338 0.00144498387695622 4786 821356 YKL052C ASK1
SGTC_3329 9141233 27.5565 µM -2.98896018111993 0.00285605084105198 no 3339 0.00139964305031055 4780 4909101 YNL103W MET4
SGTC_1146 3579-1023 7 µM -3.00807890941941 0.00270493194300053 no 3340 0.00131452431997436 4791 X1146
SGTC_3204 9114183 49.47 µM -3.07312499302473 0.00224332473077114 no 3341 0.00105914870781992 4756 17027248
SGTC_63 0099-0242 26.702 µM -3.08289192577793 0.00218054221571747 no 3342 0.00102499794712566 4789 3898502 YLR359W ADE13
SGTC_1628 st004252 77.7 µM -3.0923524382308 0.00212125236764208 no 3343 0.000992884663935672 4791 692968
SGTC_2471 5466956 24.79 µM -3.15280144024735 0.00177569230385636 no 3344 0.000808558812649408 4797 724419
SGTC_2273 7815444 169.05 µM -3.18700757027788 0.00160365525258971 no 3345 0.000718765061301075 4778 2824616
SGTC_3245 9134821 49.47 µM -3.27937299485392 0.00121223914757157 no 3346 0.000520190137876587 4803 17014901
SGTC_601 0986-0029 62.9 µM -3.28574481987446 0.00118876581757464 no 3347 0.00050856554740095 4780 24747981
SGTC_401 neomycin 50 µM -3.34187098056495 0.000999280230379407 yes 3348 0.000416078655805525 4799 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2981 9013952 38.96 µM -3.36928422355243 0.000917189381250076 yes 3349 0.000376818362281827 4776 2996344
SGTC_1675 st018485 24.5 µM -3.57672012805157 0.000470204504940822 yes 3350 0.000173966168410776 4796 3323024
SGTC_299 1273-0059 1.44 µM -3.59674550826885 0.00044002849816829 yes 3351 0.000161111728041901 4699 2848077
SGTC_2751 anetholtrithion 17.25 µM -3.68482279250013 0.000327431806377552 yes 3352 0.000114430907299317 4787 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2964 9083345 53.42 µM -4.69704428896407 6.97932541807349e-06 yes 3353 1.31976616983672e-06 4800 17741579
SGTC_690 glyoxal 20.3 µM -4.89105229172858 3.0334587824485e-06 yes 3354 5.01491557572923e-07 4799 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2963 9082507 9 µM -4.92638512267762 2.59767834599305e-06 yes 3355 4.18824107518655e-07 4808 16459611
SGTC_310 1273-0058 1.06 µM -6.20931290780473 4.62466795339777e-09 yes 3356 2.66083824428316e-10 4756 2734232