SGTCid condition conc unit ADA2|YDR448W.score ADA2|YDR448W.strain.pval ADA2|YDR448W.strain.significant ADA2|YDR448W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_429 1112-0049 25.5 µM 9.77159664085079 1.83314576120389e-16 yes 1 7.45419033580378e-23 2 2836170 SGTC_1750 st081859 2.357 µM 9.06800122260936 2.06666476040717e-14 yes 2 6.06101001059924e-20 50 5291695 SGTC_2603 homopterocarpin 100 µM 8.94362159072739 4.5964334235858e-14 yes 3 1.88310273284927e-19 1 101795 A weak amylase inhibitor. SGTC_2322 7413319 38.22 µM 8.46860424575821 8.81312003616761e-13 yes 4 1.24175456372033e-17 30 1840400 SGTC_2036 5160441 105 µM 7.85070948346776 3.24793225623976e-11 yes 5 2.06845122968924e-15 29 134534 YIL048W NEO1 SGTC_1281 0884-0031 11.8 µM 7.31361448053822 6.02174916020652e-10 yes 6 1.30025275951669e-13 4 1548255 SGTC_2409 alverine citrate 63.97 µM 6.92067704553471 4.49291608669024e-09 yes 7 2.24745081617059e-12 17 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1623 st003709 20.3 µM 6.517391066018 3.16354703241449e-08 yes 8 3.57703696193143e-11 9 16192618 SGTC_1471 k673-0312 37 µM 6.43255692201953 4.70204448004501e-08 yes 9 6.27375088890475e-11 4 24099884 SGTC_1121 fusaric acid 630.51 nM 6.07313539002899 2.38586593192507e-07 yes 10 6.27183052936753e-10 10 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3350 9150499 3.57 µM 6.02477028351764 2.94863790948945e-07 yes 11 8.46749891677369e-10 14 4910996 YPR165W RHO1 SGTC_1745 st081495 74 µM 5.91126812305963 4.81651129066041e-07 yes 12 1.69741954519181e-09 28 13842402 YBL026W LSM2 SGTC_1482 3346-2049 8.48 µM 5.80859238055282 7.45100768766441e-07 yes 13 3.15001322716863e-09 14 3826804 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 5.50227369774958 2.62367711626149e-06 yes 14 1.8746215622983e-08 36 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_162 k030-0015 37.8 µM 5.41128969014449 3.7664784399415e-06 yes 15 3.12862258877506e-08 6 1809920 YMR134W ERG29 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 5.27904399709792 6.30676655981065e-06 yes 16 6.4929812085432e-08 17 6710655 SGTC_2596 sinensetin 100 µM 5.16789870473571 9.63748393462678e-06 yes 17 1.18370275383429e-07 9 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_121 0557-0495 61.343 µM 5.16359863710443 9.79524342368881e-06 yes 18 1.21123417641411e-07 26 3104427 SGTC_1674 st016616 23.6 µM 5.12520647156726 1.13170155955642e-05 yes 19 1.4860593136932e-07 8 625830 SGTC_1624 st003710 6.25 µM 4.80554840315841 3.62307069399365e-05 yes 20 7.71639471640708e-07 26 24207033 SGTC_1376 2910-0861 41.3 µM 4.75655829424216 4.30400396533869e-05 yes 21 9.8460696366451e-07 8 1112859 SGTC_832 4083-0019 164 µM 4.73646144172802 4.61691770101036e-05 yes 22 1.0874104786963e-06 50 1990758 SGTC_1280 0880-0253 10.1 µM 4.69959328411195 5.24758924691681e-05 yes 23 1.30340064068264e-06 6 6836607 SGTC_1098 clofazimine 15.1 µM 4.69290036318838 5.37046609357146e-05 yes 24 1.34679348704856e-06 11 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_143 4032-1194 15.74 µM 4.66699743011393 5.87208320410635e-05 yes 25 1.52816575660239e-06 37 1806963 SGTC_3143 9086658 49.47 µM 4.54584674059909 8.86270028764599e-05 yes 26 2.73574200979371e-06 27 25236626 SGTC_2265 7929201 200 µM 4.53965365188254 9.04877023950559e-05 yes 27 2.81733535298469e-06 16 1265108 SGTC_658 3253-0951 102 µM 4.49122923359417 0.00010635532680875 yes 28 3.54066422598358e-06 41 1184878 SGTC_399 oxolinic acid 75 µM 4.44246829312907 0.000124946872438133 yes 29 4.44663708961278e-06 4 4628 A DNA gyrase inhibitor. SGTC_2845 9003024 42.97 µM 4.4113827636339 0.000138346346177393 yes 30 5.13562813644748e-06 32 2990173 SGTC_467 ro 31-8220 72.8 µM 4.39186903335216 0.000147433675722962 yes 31 5.61901949408159e-06 61 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2083 5306046 65.942 µM 4.38655334849551 0.000150004339026928 yes 32 5.75804646462606e-06 15 539837 SGTC_1391 3442-0225 151 µM 4.32790236934914 0.000181296043674288 yes 33 7.52680833009842e-06 7 5227075 SGTC_518 1021-0119 62.6 µM 4.31008635226981 0.000191948716986408 yes 34 8.15954050762906e-06 27 1097762 SGTC_363 0455-0021 3.06 µM 4.30112574715635 0.000197524962511199 yes 35 8.49662941996375e-06 53 4597466 SGTC_2858 9025781 8.96 µM 4.2912388432069 0.000203853104932364 yes 36 8.88395398736406e-06 82 4894980 YPL153C RAD53 SGTC_3351 9150312 21.596 µM 4.26500964062728 0.000221570745149061 yes 37 9.99467852222076e-06 31 4904905 SGTC_2006 4011487 200 µM 4.23849456318305 0.000240934463769828 yes 38 1.12511815673003e-05 73 45595294 SGTC_262 fenpropimorph 62.5 µM 4.19780821693706 0.000273738471237887 yes 39 1.34755357886429e-05 22 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2540 epiandrosterone 100 µM 4.1578904236835 0.000309926717830591 yes 40 1.60600009198634e-05 49 441302 A steroid. SGTC_1331 1472-0049 76.2 µM 4.12037066161654 0.000347954031941421 yes 41 1.89131682201955e-05 16 24051409 SGTC_3285 9112818 20.8695 µM 3.93821736204276 0.000602220253795425 yes 42 4.10446076032315e-05 29 17017947 YPR165W RHO1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.92871360756428 0.000619330067815934 yes 43 4.27007363159152e-05 18 75037 A free radical scavenger. SGTC_167 3672-0051 66.205 µM 3.91390481306942 0.000646887353471331 yes 44 4.54077237627263e-05 44 3237971 SGTC_2498 4'-Methoxychalcone 54.63 µM 3.89651051864923 0.000680699443551748 yes 45 4.87942855319948e-05 38 641818 YHR062C RPP1 SGTC_416 estradiol valerate 100 µM 3.87934351711765 0.000715661358628052 yes 46 5.23693773184832e-05 9 13791 A steroid. SGTC_1962 st076595 64.5 µM 3.86846097785584 0.000738674000787088 yes 47 5.47622297832315e-05 27 279619 SGTC_90 0870-0863 4.608 µM 3.85321494804153 0.000772061810604873 yes 48 5.82884821787797e-05 49 1738164 SGTC_1731 st035964 63 µM 3.8509013517934 0.000777248206584501 yes 49 5.88419492438131e-05 32 6739575 SGTC_520 3584-0023 682 µM 3.83243691553344 0.000819804132084574 yes 50 6.34400706644821e-05 27 1340790 SGTC_3140 9094243 49.47 µM 3.79643129555274 0.000909015749409379 yes 51 7.33970104810292e-05 27 19291112 SGTC_7 0192-1582 4.227 µM 3.78701579282832 0.000933772859163109 yes 52 7.62337064875295e-05 66 252616 SGTC_1547 harmine 94.2 µM 3.77894433460697 0.000955487419154469 yes 53 7.87473114417104e-05 52 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_402 epigallocatechin gallate 10 µM 3.77820895994614 0.00095748866420188 yes 54 7.89801572382988e-05 33 65064 An antioxidant. SGTC_207 4185-0010 4.486 µM 3.74507775298618 0.00105174704024522 no 55 9.01689580320677e-05 98 3761753 SGTC_2526 patulin 37.61 µM 3.74020138893684 0.00106631742326965 no 56 9.19364366555473e-05 98 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1155 4088-0394 48.2 µM 3.73897557834009 0.00107000909293275 no 57 9.23858370156368e-05 36 2326248 SGTC_3220 9131269 49.47 µM 3.71698371504368 0.00113826280291811 no 58 0.000100807716764045 15 17722206 SGTC_486 niguldipine 82 µM 3.71277429113951 0.00115177333090374 no 59 0.00010249984828787 20 1236 A calcium channel blocker. SGTC_1100 amiodarone 5.07 µM 3.66811531286076 0.00130443194195848 no 60 0.000122172492476634 23 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2300 7976697 71.57 µM 3.66651407658801 0.00131023418638836 no 61 0.000122939695006437 39 2236109 SGTC_1026 k007-1105 30.6 µM 3.66647760370811 0.00131036662402905 no 62 0.000122957222835352 107 7066794 SGTC_1687 st020778 55.3625 µM 3.62527191314962 0.00146805310709054 no 63 0.000144328784599202 190 4259299 SGTC_2405 ticlatone 3.52 µM 3.62156505636173 0.00148305543111108 no 64 0.000146413072417216 78 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1137 ixabepilone 100 µM 3.5948135001186 0.00159553919295839 no 65 0.000162312018329783 40 154225 A novel microtubule stabilizer. SGTC_2838 9002687 71.43 µM 3.58850980056485 0.00162315226174127 no 66 0.000166286746794422 30 6457060 SGTC_2925 9010536 32.5 µM 3.57357511098073 0.00169031911212243 no 67 0.000176070085039079 65 2994177 SGTC_1680 diphenhydramine 100 µM 3.57018387365553 0.00170591908320515 no 68 0.000178365366952059 42 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1884 5633444 25 µM 3.56858532759614 0.00171331788266073 no 69 0.000179456983081232 70 5724239 SGTC_3311 9131146 2.8755 µM 3.54873329296052 0.00180766767902812 no 70 0.000193544466871523 138 4900406 YPR165W RHO1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 3.54805334505187 0.00181098136773884 no 71 0.000194044805730179 90 6708739 YPR165W RHO1 SGTC_3201 9113999 49.47 µM 3.54287792265673 0.00183638511529117 no 72 0.000197892935808385 53 16649224 SGTC_2769 toremifene 3.73 µM 3.54218110911297 0.00183983008795923 no 73 0.000198416456814821 34 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_92 0063-0024 660.874 µM 3.53370859871743 0.00188218991107455 no 74 0.000204886295331679 20 3594437 SGTC_2929 9013348 24.6 µM 3.53174575267853 0.00189212912061273 no 75 0.000206413033312108 38 2995952 SGTC_1964 st076914 61 µM 3.53015935614252 0.00190019694040849 no 76 0.000207654719260802 33 24208661 SGTC_1620 st003704 16.5 µM 3.48081560254035 0.00216728741265003 no 77 0.000249944755312414 29 2834414 SGTC_1156 4092-0367 4.88 µM 3.43842051287913 0.00242346877014755 no 78 0.00029255914509106 37 1357585 SGTC_3194 9111903 49.47 µM 3.43811339609515 0.0024254205678555 no 79 0.000292891168356212 36 17087251 SGTC_642 0335-0876 158 µM 3.43382277647434 0.00245283756451314 no 80 0.000297566582967829 57 6812350 SGTC_2038 4100038 30.985 µM 3.43022123749284 0.0024760674308194 no 81 0.000301544651038409 74 3596803 SGTC_3296 9122258 64.045 µM 3.41026550266368 0.00260842475273026 no 82 0.00032449833524106 33 4730474 SGTC_2907 7721985 69.9 µM 3.40723758842949 0.00262905678185739 no 83 0.000328119882173168 47 3267881 SGTC_2776 terbinafine 19.92 µM 3.39361021719172 0.00272374953822378 no 84 0.000344888974978092 75 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1481 3346-2004 36 µM 3.37444997481989 0.00286209790861338 no 85 0.000369816788473574 21 2770522 SGTC_1781 st038725 66.3 µM 3.37340807742106 0.00286979960211497 no 86 0.000371219156354813 133 4270275 YIL048W NEO1 SGTC_2623 humulene 100 µM 3.34042811865374 0.00312345391777159 no 87 0.000418246657901889 40 6187145 An anti-inflammatory. SGTC_3303 9125618 40.5795 µM 3.27776787767138 0.00366161974951246 no 88 0.000523156992981057 74 22695467 SGTC_953 1188-0045 9.7 µM 3.26242274994423 0.00380549343687214 no 89 0.000552321375284479 53 6144426 SGTC_1428 4049-0204 61.7 µM 3.26127830938822 0.0038164239439767 no 90 0.000554555609984055 30 X1428 SGTC_3146 9095609 49.47 µM 3.25463578174947 0.00388042398273409 no 91 0.000567689355680612 45 17173999 SGTC_53 0973-0023 39.979 µM 3.18830033194217 0.00457429220510702 no 92 0.00071555904453809 34 674768 SGTC_1967 st070177 51.4 µM 3.17598421900349 0.00471467805178776 no 93 0.00074664537206324 45 5729214 SGTC_622 1348-1566 26.3 µM 3.09998747972766 0.00566910993272289 no 94 0.00096764411547639 53 7340407 SGTC_930 2810-3379 265 µM 3.09293045145671 0.00576589990071977 no 95 0.000990952882147268 40 1015764 SGTC_221 trifluoperazine 10.304 µM 3.08153733909274 0.00592525803076418 no 96 0.00102967323273537 273 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_138 0850-0259 40.9225 µM 3.06467978237097 0.00616821456936057 no 97 0.00108951582416028 268 6813004 SGTC_1622 st003707 19.4 µM 3.03753365822369 0.00657802730197708 no 98 0.00119261382759379 94 10140899 SGTC_2264 7948757 110.76 µM 3.02176982907305 0.00682689971980486 no 99 0.00125650777292447 63 2971411 SGTC_1106 tegaserod maleate 11.7 µM 3.01587004562628 0.00692216026813968 no 100 0.00128121528306576 75 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1539 benzyladenosine 56 µM 3.01281199099306 0.00697199732404664 no 101 0.00129419610434965 44 92208 A nucleotide analog. SGTC_201 4262-0159 12.803 µM 3.01057708115477 0.00700861967714014 no 102 0.00130375877765555 81 1341029 SGTC_2249 haloperidol 116.36 µM 3.00171207764648 0.00715556396315425 no 103 0.00134232981942195 191 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2028 5153890 36.43 µM 2.99851333158852 0.00720924907830169 no 104 0.00135650143289492 67 2830968 YPR165W RHO1 SGTC_986 1493-0483 84 µM 2.98074781167866 0.00751392426320052 no 105 0.00143772741293525 50 40079 SGTC_208 k072-0098 12.366 µM 2.97638323651699 0.0075904895797246 no 106 0.00145835063157281 103 5948901 SGTC_1850 st056238 17 µM 2.95979763301774 0.00788774325154653 no 107 0.00153920591235554 66 5393177 SGTC_1278 0874-0585 172 µM 2.94693582412229 0.00812525862540923 no 108 0.00160469901447877 56 766306 SGTC_417 st075190 100 µM 2.94073713159978 0.00824195606757557 no 109 0.00163716135944999 54 222757 SGTC_1144 3486-0183 12.5 µM 2.93125042845093 0.00842340496629906 no 110 0.001688002543275 70 6744069 SGTC_677 0929-0063 136 µM 2.91521013715367 0.00873818622463561 no 111 0.0017772456116124 46 1539583 SGTC_637 1181-0519 7.26 µM 2.89683051027015 0.0091115133778699 no 112 0.00188476673107717 166 6252091 YGR060W ERG25 SGTC_1709 st033179 39.1045 µM 2.8625423762762 0.00984542990563504 no 113 0.00210128529239865 65 573381 SGTC_1328 1441-0025 69.2 µM 2.83821004414 0.0103970863791879 no 114 0.0022683658756494 48 4562601 SGTC_2497 7-hydroxyflavone 100 µM 2.82692812196401 0.0106618823212128 no 115 0.00234984377627767 69 5281894 SGTC_1285 0929-0069 65.5 µM 2.82376379677782 0.0107371983948936 no 116 0.00237316746635219 80 1206237 SGTC_538 2922-0838 53.3 µM 2.81790188337514 0.0108779460105226 no 117 0.00241692893943277 98 777039 SGTC_2778 tioconazole 65.09 nM 2.81702423911746 0.0108991563141316 no 118 0.00242354337175257 135 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2082 5219693 150 µM 2.80446319835677 0.0112066896887414 no 119 0.00252002204709429 94 2834649 SGTC_2178 5812956 200 µM 2.80195259829869 0.0112690535784749 no 120 0.00253971681629735 63 5403383 SGTC_2709 st078560 56 µM 2.78643484972728 0.0116612526904221 no 121 0.00266456646469359 53 17250903 SGTC_1324 1418-0026 34.4 µM 2.7817614607987 0.0117816672442649 no 122 0.00270323808902107 65 1372513 SGTC_390 dec-rvkr-cmk 16.7 µM 2.77729065210715 0.0118978704932508 no 123 0.0027407069084644 102 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_408 cantharidin 100 µM 2.77266718855567 0.0120190859140692 no 124 0.00277994754359424 88 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1608 st001473 40.5 µM 2.76540575450021 0.0122116238326507 no 125 0.00284260152578043 97 7292267 SGTC_1314 1222-0010 41.1 µM 2.7269045554363 0.0132777634465035 no 126 0.00319657643101185 64 3526027 SGTC_855 0428-0020 25 µM 2.71585038616044 0.0135983483552157 no 127 0.00330528921097297 67 6812414 SGTC_1238 0333-0287 48.8 µM 2.7080401740834 0.0138288618840189 no 128 0.00338409145025603 101 7226 SGTC_2117 5521686 200 µM 2.68717763885431 0.0144611980126089 no 129 0.00360293096428007 85 803312 SGTC_1222 0366-0074 1.18 µM 2.67599637898541 0.0148102306739481 no 130 0.0037253725056378 79 286520 SGTC_3283 9109332 35.8195 µM 2.67325635327649 0.0148968599709023 no 131 0.00375594109146678 68 17027281 SGTC_2416 tofa 880 nM 2.67215341958126 0.0149318533655568 no 132 0.00376830912220978 126 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2624 nerol 100 µM 2.65992477355556 0.0153245977066183 no 133 0.00390790529908579 72 637566 A natural product oil. SGTC_471 1-acyl-paf 4 µM 2.65316574832861 0.0155454583735655 no 134 0.00398703518251898 96 16759367 SGTC_1451 4152-0210 104 µM 2.65240828977389 0.0155703787964197 no 135 0.0039959917848374 118 659563 SGTC_1717 st033143 58.0435 µM 2.6437036567706 0.0158592311832089 no 136 0.00410022083898509 138 674616 SGTC_768 0384-0033 77.3 µM 2.63999009375374 0.0159838524903166 no 137 0.00414542253113261 184 3965305 YMR134W ERG29 SGTC_1395 3486-0190 4.35 µM 2.62221829658781 0.0165919313037748 no 138 0.00436797275786327 99 6748079 SGTC_422 cantharidin 155 µM 2.62157624654204 0.0166142652343651 no 139 0.00437620909044605 159 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2437 5741531 144.16 µM 2.61293847546862 0.0169172431403658 no 140 0.00448837301992483 114 2262990 SGTC_2017 5132927 60.65 µM 2.58922246651304 0.0177735028909411 no 141 0.0048096463809313 125 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2202 7226349 200 µM 2.58728074297389 0.0178452176284852 no 142 0.0048368369573274 68 844334 SGTC_2449 5812982 45.77 µM 2.58009607934653 0.0181127228671248 no 143 0.00493864150258397 69 776185 SGTC_1638 st008370 60.6 µM 2.57708312778173 0.0182259166180945 no 144 0.0049818992736618 123 24207134 SGTC_688 0527-0193 473 µM 2.57391452733241 0.0183456077118627 no 145 0.00502775554591325 68 4007154 SGTC_288 1315-0019 35.1 µM 2.57372422118878 0.0183528176252567 no 146 0.00503052160182598 112 6811474 SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.55446739687622 0.0190949659589428 no 147 0.00531751945184371 141 1273210 SGTC_1983 st071813 46.9 µM 2.54815335012041 0.0193437959015548 no 148 0.00541474275056083 102 11838595 SGTC_2097 5376186 200 µM 2.53987806371154 0.0196740836700022 no 149 0.00554455613732506 117 742755 SGTC_2099 5377090 177.372 µM 2.53911648875778 0.0197047192535937 no 150 0.00555664067777648 121 2243829 SGTC_2183 6420625 130.508 µM 2.53741788907434 0.0197731940949181 no 151 0.0055836780870295 183 2897619 SGTC_2762 leflunomide 42.06 µM 2.52532627289814 0.0202664978637317 no 152 0.0057795458431731 128 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1950 st077106 7.18 µM 2.52199222533727 0.0204043387132512 no 153 0.00583461436599264 120 13831864 SGTC_1673 st016611 27.3 µM 2.50921790717165 0.0209398492542842 no 154 0.00604994082944204 163 5226799 SGTC_227 fluconazole 33.516 µM 2.50344089980809 0.0211859051926317 no 155 0.0061496109902489 186 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1518 st038567 90.8 µM 2.49673588695313 0.0214745492668432 no 156 0.00626711365681924 97 77966 SGTC_1448 4255-0083 152 µM 2.49519355231832 0.0215414134698723 no 157 0.00629442206340696 102 5399660 SGTC_550 4123-0385 25.7 µM 2.49062181382627 0.0217406448027841 no 158 0.00637598871323971 139 5731123 SGTC_3225 9130819 49.47 µM 2.47824011845423 0.0222880569772517 no 159 0.00660161282107711 106 4547121 SGTC_1513 0337-0559 19 µM 2.47387252503123 0.0224839085896155 no 160 0.00668286889082348 130 775073 SGTC_918 glabranin 770.725 nM 2.46561155157771 0.0228583166375287 no 161 0.00683897887890471 129 124049 Also referred to as licorice root. SGTC_1005 4092-0690 4.4 µM 2.46246935697051 0.0230021012308547 no 162 0.00689919816254521 127 1529343 SGTC_2947 9072639 7.68 µM 2.4616922286153 0.0230377793359467 no 163 0.00691416364244727 180 16488146 SGTC_136 0097-0015 404.482 µM 2.46038725885025 0.0230977955732354 no 164 0.00693935846871063 137 4861337 SGTC_2297 7971671 152.32 µM 2.45302983974018 0.0234386359239581 no 165 0.00708292935032529 116 909016 SGTC_1101 ebselen 5.29 µM 2.44183035026376 0.023965581972055 no 166 0.00730650592772138 129 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3250 9135583 49.47 µM 2.43979161600681 0.0240625694873245 no 167 0.00734786813638222 82 7699353 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.43921976759534 0.0240898328456081 no 168 0.00735950690287683 122 6312947 SGTC_1003 4049-0218 100 µM 2.42968123282537 0.0245484306837995 no 169 0.00755605372603439 155 295161 SGTC_2068 5226020 147 µM 2.42854641355008 0.0246034755584194 no 170 0.00757974231455536 166 1810509 SGTC_3321 9137793 26.8275 µM 2.42517555033364 0.0247675917455515 no 171 0.00765049289968008 194 4904192 SGTC_1154 4088-0362 150 µM 2.41579284187665 0.025229246783422 no 172 0.00785049565954398 162 6618304 SGTC_2385 9074692 200 µM 2.41551435643755 0.0252430584781549 no 173 0.00785650152220029 148 17046906 SGTC_1472 k841-0093 193 µM 2.41445173688249 0.0252958181171614 no 174 0.0078794553004642 136 X1472 SGTC_93 0109-0045 59.227 µM 2.40990844808567 0.0255224379329263 no 175 0.00797826202308586 162 88733 SGTC_868 0527-0199 213 µM 2.4049934065432 0.0257695127870036 no 176 0.00808637878750354 135 2849450 SGTC_2090 5301565 104.445 µM 2.40060096658508 0.0259920077465251 no 177 0.00818408726197786 169 2056344 SGTC_1655 st012546 55.1 µM 2.39230081039224 0.0264168324619128 no 178 0.00837155678027101 116 720985 YLR208W SEC13 SGTC_676 falcarinol 140 µM 2.3909555841938 0.0264862283026094 no 179 0.00840229284035328 158 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2927 9011802 47.9 µM 2.38043592604195 0.0270341733632211 no 180 0.00864608400392801 148 43912568 SGTC_1478 0453-0656 35.7 µM 2.37269852424673 0.0274432081526341 no 181 0.00882933529721955 111 5258496 SGTC_1690 st023502 41.2 µM 2.37066523303772 0.027551549488211 no 182 0.00887805267701837 110 24207482 SGTC_418 lividomycin a 100 µM 2.36952890202297 0.0276122525989028 no 183 0.00890538149101983 119 72394 An antibiotic. SGTC_2367 9070478 135.38 µM 2.35083748816156 0.0286268554214794 no 184 0.00936560634610909 160 572802 SGTC_717 1532-0246 73.2 µM 2.35073428516677 0.0286325423928346 no 185 0.00936820413900467 155 9561992 SGTC_2495 cafestol 54.53 µM 2.34928812612506 0.028712331451276 no 186 0.00940467274977088 150 16667697 An anti-infammatory. SGTC_301 4119-0100 24.5 µM 2.34627328829526 0.0288792639278308 no 187 0.00948109908746221 210 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2593 nobiletin 86.24 µM 2.34258999754461 0.0290843029413903 no 188 0.00957520736439414 145 72344 An anti-infammatory. SGTC_1111 tnp00062 510.699 nM 2.33502440052918 0.0295092545095655 no 189 0.00977107304308335 121 676306 SGTC_2065 5221596 34.26 µM 2.33445144147228 0.0295416458843677 no 190 0.00978604793921753 132 788581 SGTC_2173 5763948 167 µM 2.32561949877518 0.0300446912163422 no 191 0.0100194292157506 127 2867177 SGTC_1488 4013-0813 75.9 µM 2.32327577201328 0.0301793701587331 no 192 0.0100821712511755 91 2910057 SGTC_232 clozapine 119 µM 2.32288001553256 0.0302021610569494 no 193 0.0100927994965974 195 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_900 1112-0045 141 µM 2.31277078713907 0.030789186910219 no 194 0.0103676223655394 117 56211 YIL048W NEO1 SGTC_54 0159-0055 9 µM 2.30810850094806 0.031063083645168 no 195 0.0104965512446002 148 3319099 SGTC_2610 ononetin 44.17 µM 2.30386928768645 0.031313872907438 no 196 0.0106149911007737 204 259632 SGTC_445 e6 berbamine 66 µM 2.30372278852542 0.0313225695526388 no 197 0.0106191048839243 303 6610268 A calcium/calmodulin antagonist. SGTC_2973 9094665 17.96 µM 2.29136132190988 0.0320636114173577 no 198 0.0109712623220313 183 25237061 YIL048W NEO1 SGTC_1060 3448-7350 82 µM 2.28588221969156 0.0323966704994416 no 199 0.0111305749524074 146 570178 SGTC_2934 9036370 36.88 µM 2.28488043710916 0.0324578736260355 no 200 0.0111599197128281 184 6462800 SGTC_483 fpl-64176 144 µM 2.28319614310962 0.0325609892473398 no 201 0.0112094086064688 88 3423 SGTC_463 ikarugamyin 104 µM 2.28227781738149 0.0326173245891258 no 202 0.0112364716666645 52 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1496 4469-0713 57.4 µM 2.27861395134349 0.0328428877335862 no 203 0.0113450119375021 121 746691 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.27854690234861 0.0328470275050433 no 204 0.0113470066914449 201 6728940 SGTC_2280 7785178 200 µM 2.27561724782547 0.0330283320877511 no 205 0.0114344640514184 129 2954328 SGTC_367 0335-0881 7.1 µM 2.26452091873941 0.0337225310623929 no 206 0.0117710473196026 227 23828853 SGTC_3011 9081274 71.4286 µM 2.25787625293813 0.0341439457729502 no 207 0.0119766877556446 168 6625322 SGTC_2824 7998404 51.95 µM 2.2392007697381 0.0353516064078833 no 208 0.0125714278964225 154 837851 SGTC_2846 9008642 19.48 µM 2.23215273206746 0.0358163824680634 no 209 0.0128024351215137 145 2992898 SGTC_1149 3909-7961 23.3 µM 2.22519096259681 0.0362803731026262 no 210 0.0130342106448733 175 735261 SGTC_3192 9110362 49.47 µM 2.22402534710838 0.0363585382847171 no 211 0.0130733694581123 130 16649480 SGTC_2251 lansoprazole 556 µM 2.22343246224654 0.0363983494928849 no 212 0.0130933263915126 131 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3166 9102297 49.47 µM 2.21883500338832 0.0367082734001055 no 213 0.013248975848642 187 25237072 SGTC_2049 5262831 67.185 µM 2.21437339543458 0.0370110997208153 no 214 0.0134015517417417 181 763417 SGTC_786 4544-0069 423 µM 2.21153958646232 0.0372044993523899 no 215 0.0134992468577058 188 748821 YLR208W SEC13 SGTC_1288 0973-0013 65.5 µM 2.2047561478228 0.0376708058164055 no 216 0.0137356053819521 164 4315430 SGTC_1619 st003326 88.7 µM 2.20094519347715 0.0379348643059764 no 217 0.0138699520025077 134 2849032 SGTC_3147 9097027 49.47 µM 2.19739321486643 0.0381823364485025 no 218 0.0139961877248712 171 25236841 SGTC_1803 st050068 52.4 µM 2.19648276272246 0.0382459806771834 no 219 0.0140287038028245 424 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2735 sertaconazole 140 nM 2.19396669546488 0.0384223137516923 no 220 0.0141189019619411 100 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1901 st060216 58.6 µM 2.1929582049613 0.0384931773956669 no 221 0.0141551952495215 171 688792 SGTC_79 0052-0007 94.094 µM 2.1846975654252 0.0390776462698716 no 222 0.0144555144105136 184 2801472 SGTC_978 1416-0512 87.4 µM 2.18335635363036 0.0391732198840052 no 223 0.014504788761327 196 6814003 SGTC_1307 1187-1599 12.2 µM 2.18260065080986 0.0392271543718237 no 224 0.0145326159120871 167 1538471 SGTC_578 3460-0051 92 µM 2.18093270110974 0.0393464098035983 no 225 0.0145941972836529 181 2876744 SGTC_3098 9119039 49.47 µM 2.1790065452858 0.0394844933675651 no 226 0.0146655909930922 185 17161528 SGTC_2041 5107442 45.335 µM 2.17211682887597 0.0399816379747174 no 227 0.0149234259624279 201 793005 SGTC_3279 9140807 49.47 µM 2.16670321541016 0.0403758293988886 no 228 0.0151287456349963 144 45595718 SGTC_1136 pergolide 1.05886 µM 2.16420566393885 0.0405587490855179 no 229 0.0152242843998603 276 47811 A dopamine receptor agonist. SGTC_2967 9089538 49.85 µM 2.14454845886528 0.0420220302527843 no 230 0.0159944834979883 210 728216 SGTC_2153 5569715 200 µM 2.14282177200834 0.0421525808179453 no 231 0.0160637061891679 139 2054701 SGTC_1737 st035557 69.7 µM 2.1403630504067 0.0423390449819674 no 232 0.0161627190908848 152 5716916 SGTC_3074 9116018 49.47 µM 2.13849305730432 0.0424813075148899 no 233 0.0162383735067213 150 17027303 SGTC_2807 7945238 51.95 µM 2.13303374908077 0.0428988455028276 no 234 0.0164609788837429 210 17148797 SGTC_555 4296-0685 37 µM 2.12417434678704 0.0435834810679741 no 235 0.0168277837466488 169 2908540 YHR072W ERG7 SGTC_576 1073-0113 22.7 µM 2.12145800295424 0.0437951517698943 no 236 0.0169416392767145 308 5439563 SGTC_776 4476-4378 112 µM 2.10577819615421 0.0450332598358199 no 237 0.017611811831022 161 2892008 SGTC_218 alverine citrate 93.75 µM 2.10292885377187 0.0452612456807994 no 238 0.0177359945785568 153 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2155 5570423 76 µM 2.09810109067746 0.045649650561817 no 239 0.0179481081229625 158 797402 SGTC_381 3461-2219 42.7 µM 2.09357700490778 0.0460160515266401 no 240 0.0181488388811718 193 2883159 SGTC_2388 9080168 200 µM 2.09022163554577 0.0462893223279359 no 241 0.0182989474469079 137 15943073 SGTC_2475 5812728 15.03 µM 2.09017107609596 0.0462934499765399 no 242 0.0183012173813068 200 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_626 0214-0009 33 µM 2.08959593886939 0.046340424701686 no 243 0.0183270558300259 181 3437874 SGTC_96 0929-0093 37.281 µM 2.0841401403475 0.0467879365761792 no 244 0.0185737108774725 175 6991579 SGTC_1557 sumaresinolic acid 42.3 µM 2.08036936434419 0.0470992556423037 no 245 0.0187458334943965 196 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1512 0259-0544 12.2 µM 2.07853414190761 0.0472513731457555 no 246 0.018830094830091 223 18476 SGTC_2330 7979373 200 µM 2.07738196910915 0.0473470752243531 no 247 0.018883159514968 233 1863007 SGTC_2302 7771753 200 µM 2.06991765578082 0.0479708463726979 no 248 0.0192300281294698 255 2203047 SGTC_1049 3226-0134 66 µM 2.06929123347035 0.0480234924598252 no 249 0.0192593828979583 231 5702385 SGTC_987 1497-1013 404 µM 2.06831073519206 0.0481059887947695 no 250 0.0193054064714064 157 1676435 SGTC_1627 st003713 25.6 µM 2.06555948615059 0.0483380767144947 no 251 0.0194350466048223 328 16195070 YER133W GLC7 SGTC_2185 6113692 200 µM 2.06522597463103 0.0483662716064803 no 252 0.0194508119678905 177 874150 SGTC_2897 9048598 12.99 µM 2.06460015067191 0.0484192139399881 no 253 0.0194804245001235 165 6467404 SGTC_2134 5324836 1.464 µM 2.0614532779752 0.0486861302621997 no 254 0.0196299082428005 156 699272 SGTC_885 0865-0106 16.8 µM 2.05851695466092 0.0489362474178145 no 255 0.0197702677158805 225 2793380 SGTC_1029 k015-0030 64.7 µM 2.05748132613172 0.0490247071696752 no 256 0.0198199746864617 214 2208316 SGTC_824 1304-0008 100 µM 2.05503870043339 0.049233853659077 no 257 0.0199376334374315 245 768245 SGTC_3152 9099253 49.47 µM 2.04256697180385 0.0503128580126484 no 258 0.0205476617142954 368 25236131 SGTC_2381 9035592 200 µM 2.03998240463756 0.0505388047924911 no 259 0.0206760391323899 196 4749657 SGTC_2974 9094440 9.66 µM 2.0392432221422 0.050603573682188 no 260 0.0207128795727265 245 25236134 SGTC_3054 9094397 49.47 µM 2.03626649970995 0.0508650705262142 no 261 0.0208618009225932 249 2598354 SGTC_1760 st045453 10.4495 µM 2.03609525397752 0.050880146655975 no 262 0.0208703956140978 317 3323419 YIL048W NEO1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.03478601166556 0.0509955273176319 no 263 0.020936204591746 184 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2908 7930301 100 µM 2.03323486087159 0.051132496277211 no 264 0.0210144003134229 254 2223178 SGTC_2512 diallyl trisulfide 49.23 µM 2.03130073583057 0.0513036923525879 no 265 0.0211122483942854 142 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1012 4112-3522 18 µM 2.03101990261518 0.051328587734765 no 266 0.0211264878446811 218 3112398 SGTC_2267 7931562 200 µM 2.02887210173792 0.0515193045257776 no 267 0.0212356594964712 192 934880 SGTC_740 k014-0057 261 µM 2.02722012481829 0.0516663770218617 no 268 0.0213199529567129 235 4012779 SGTC_2342 7990637 118.86 µM 2.02688053731929 0.051696651196758 no 269 0.0213373156979513 233 2033102 YER133W GLC7 SGTC_3078 9116413 49.47 µM 2.02540661237279 0.0518282148499671 no 270 0.0214128145165273 211 17177322 SGTC_1943 st076331 65.2 µM 2.01203132955636 0.0530343011194136 no 271 0.0221083172657987 203 24208415 SGTC_981 1488-1094 54.9 µM 2.0112985220676 0.0531010181701597 no 272 0.0221469672621559 165 3449522 SGTC_2552 juarezic acid 87.02 µM 2.00768309854757 0.0534311520859249 no 273 0.022338488891097 254 1549512 SGTC_313 3474-0040 5.03 µM 2.00643933870467 0.0535450983665628 no 274 0.0224046973674721 307 1043375 YIL048W NEO1 SGTC_1386 3228-0095 33.8 µM 2.00264169962663 0.0538942083605306 no 275 0.0226078803147618 196 870181 SGTC_1841 st054148 70 µM 2.00249960702507 0.0539073055668107 no 276 0.0226155126650265 197 675442 SGTC_120 rhodamine 6G 52.259 µM 2.0003503173951 0.0541057211220302 no 277 0.0227312245981654 292 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1809 st050081 57.6 µM 1.99802271437324 0.0543212494570705 no 278 0.0228570988052368 215 5036894 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.98896185259114 0.0551667304640567 no 279 0.0233527068648834 299 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_638 3970-0837 4.09 µM 1.98166098477775 0.055855518390013 no 280 0.0237585983247489 235 4118451 YLR208W SEC13 SGTC_749 1000-0129 128 µM 1.9778964998077 0.0562133139974607 no 281 0.0239701919542512 241 708470 SGTC_400 oxethazaine 37.5 µM 1.97755280708309 0.0562460701034921 no 282 0.0239895888316541 219 4621 A local anesthetic. SGTC_1302 1159-0335 255 µM 1.97259520148076 0.0567202374418593 no 283 0.0242708500775293 197 649284 SGTC_1020 4335-0961 93.3 µM 1.97199130874464 0.0567782109235033 no 284 0.0243052993459612 213 669075 SGTC_2661 dactinomycin 12.96 µM 1.97150170944264 0.0568252465264914 no 285 0.0243332588352976 225 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1920 st075728 45.7 µM 1.95919525614251 0.0580176323960067 no 286 0.0250449622437792 236 3400306 SGTC_2326 6164455 177.58 µM 1.95918931889191 0.0580182123719062 no 287 0.0250453097719405 219 2888790 SGTC_2600 tangeritin 87.95 µM 1.95621210109647 0.0583096141142858 no 288 0.0252200867929275 214 68077 A bioactive flavone. SGTC_1446 4239-0190 62 µM 1.9488591714317 0.0590342243491049 no 289 0.0256561225290334 278 1340085 SGTC_1754 st042065 16.137 µM 1.94410395758907 0.059506585843218 no 290 0.0259414580630002 438 1126236 YIL048W NEO1 SGTC_1070 indatraline 8.81 µM 1.94365778012917 0.0595510586912898 no 291 0.0259683665526915 252 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1059 3448-6867 171 µM 1.94201806725907 0.0597147212816618 no 292 0.0260674565603181 227 3934407 SGTC_1495 4469-0029 237 µM 1.94047325093128 0.0598692342948067 no 293 0.026161100965767 382 793680 SGTC_2343 7990716 14.84 µM 1.93905411958894 0.0600114520758665 no 294 0.0262473742821253 226 6456862 SGTC_224 benfluorex 43.875 µM 1.93853588877771 0.0600634523014092 no 295 0.0262789383439091 130 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_398 bronopol 33.3 µM 1.93542877206365 0.0603759663275754 no 296 0.0264688507173095 242 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3229 9132204 49.47 µM 1.92046803721874 0.0618985661431359 no 297 0.0273994033611814 153 17682924 SGTC_604 1000-0114 314 µM 1.90012733335219 0.0640165730324354 no 298 0.0287082057449778 256 1572745 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.89443045889818 0.0646197583584098 no 299 0.0290839483468261 272 4174840 SGTC_3182 9108849 49.47 µM 1.89086374225571 0.0649996436771334 no 300 0.0293212677805837 288 17133045 SGTC_2110 5483698 200 µM 1.88648027954242 0.0654688909714015 no 301 0.0296151317010116 237 2848765 YHR062C RPP1 SGTC_1777 st045864 34.765 µM 1.88391486277111 0.0657447336807617 no 302 0.0297882462406669 231 4691462 SGTC_2172 5754775 163.918 µM 1.88048534730658 0.0661148935097232 no 303 0.0300209807505546 264 2263357 SGTC_2119 5528445 120.635 µM 1.87684403484632 0.0665096783119902 no 304 0.0302697365810863 241 791935 SGTC_230 MPP+ 141.667 µM 1.87475409753942 0.0667370885665149 no 305 0.0304132803795791 245 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.86744971937748 0.0675366210122751 no 306 0.0309194060740063 304 23847180 SGTC_1759 st043059 70 µM 1.86721449889129 0.067562490573649 no 307 0.0309358198368881 265 669426 SGTC_1485 3909-9022 254 µM 1.86523098477154 0.0677809421713911 no 308 0.0310745170967508 248 714516 SGTC_2699 st077704 54.6 µM 1.86151150369783 0.0681920523327998 no 309 0.0313359888177444 286 645852 SGTC_1474 0330-0125 5.35 µM 1.85890882469107 0.068480866246945 no 310 0.0315200315211646 253 X1474 SGTC_1613 st002381 52.1 µM 1.85718511985542 0.068672661036366 no 311 0.0316424106356641 275 551167 SGTC_1671 st016596 74.5 µM 1.84228107480214 0.0703483350192271 no 312 0.032717023283525 291 2829167 SGTC_1883 5-benzylidenerhodanine 20 µM 1.84221688458733 0.0703556193693617 no 313 0.0327217158121872 363 1273210 SGTC_2868 9035608 32.47 µM 1.84140980969856 0.0704472562834837 no 314 0.0327807631697088 287 6462614 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.83733514970336 0.0709113030831676 no 315 0.0330802169675682 256 4213774 SGTC_2906 7926292 26.41 µM 1.83539117051196 0.0711335208408524 no 316 0.0332238755161394 282 2966319 SGTC_1079 idarubicin 2.36 µM 1.83259556238019 0.0714540258730105 no 317 0.0334313692918722 235 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2250 alverine citrate 130 µM 1.82534093960017 0.072290907829633 no 318 0.0339747979028083 491 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1531 st059297 52.4 µM 1.82517147146586 0.0723105468072196 no 319 0.033987578731282 273 7566702 SGTC_19 0279-0214 38.434 µM 1.82461895472086 0.0723746041350071 no 320 0.0340292755137874 369 3566274 YBR002C RER2 SGTC_2642 cholecalciferol 100 µM 1.82046693412029 0.0728573702344709 no 321 0.0343439636575897 235 9821465 A vitamin D precursor, similar to steriods. SGTC_1372 2752-0194 270 µM 1.81786451824153 0.0731612142844663 no 322 0.0345424212874072 259 823334 SGTC_674 0498-0004 451 µM 1.81775192292362 0.0731743821557188 no 323 0.0345510289106812 294 4231473 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.81724781293161 0.0732333593775812 no 324 0.0345895884332674 251 97141 SGTC_1305 1181-0477 144 µM 1.81329701782111 0.073696833862406 no 325 0.0348930115086345 261 6252086 SGTC_3110 9122132 49.47 µM 1.81320914948345 0.0737071672767342 no 326 0.0348997846001091 251 918317 SGTC_2682 pyrogallin 40.03 µM 1.81073535723425 0.073998542746598 no 327 0.0350909134679548 316 822798 An ATP competetive kinase inhibitor. SGTC_926 2268-1401 59.4 µM 1.81072995142147 0.0739991804321921 no 328 0.0350913320676943 290 2931578 SGTC_2168 5727979 200 µM 1.81068854995125 0.0740040644107527 no 329 0.0350945381312069 252 695210 SGTC_397 arbidol 50 µM 1.80951296800116 0.0741428462750878 no 330 0.0351856736667195 297 131410 A RNA synthesis inhibitor. SGTC_2962 9082311 13.18 µM 1.80862068702159 0.0742483160388533 no 331 0.0352549761841082 250 16459453 SGTC_1460 k062-0059 9.15 µM 1.80510578851791 0.0746649004465442 no 332 0.0355290647209218 260 1373085 SGTC_454 lyso-paf C-16 6.67 µM 1.8030267677246 0.074912143372329 no 333 0.0356920054638393 278 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2767 sibutramine 71.45 µM 1.80119325777108 0.0751307072933941 no 334 0.0358362123457966 275 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2971 9092186 9.93 µM 1.79921125438425 0.0753675189606359 no 335 0.0359926349234119 264 25236400 SGTC_3291 9121177 71.43 µM 1.79911331278208 0.0753792358523164 no 336 0.0360003790942561 237 17015612 SGTC_982 1491-0518 27.5 µM 1.79834891452494 0.0754707295989629 no 337 0.0360608664074598 252 3091256 SGTC_35 0133-0054 64.071 µM 1.79055080942178 0.0764089558384406 no 338 0.0366827033984102 279 99677 SGTC_834 0312-0008 75.7 µM 1.79041260067451 0.0764256640460746 no 339 0.0366938030564885 345 6385573 YIL048W NEO1 SGTC_2752 diclazuril 33.15 µM 1.79035099145468 0.0764331129481538 no 340 0.0366987518287176 453 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2341 7987486 176.74 µM 1.78696188006704 0.076843727109296 no 341 0.0369718249588411 315 1258686 SGTC_64 000l-0018 272.079 µM 1.78585200667537 0.0769785597989806 no 342 0.037061611754411 472 6811119 SGTC_1297 1068-0111 14.1 µM 1.78156371239171 0.0775012121727272 no 343 0.0374102032037831 262 767057 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.77371681977864 0.0784645529723253 no 344 0.0380550014282382 369 368090 SGTC_2314 7727897 200 µM 1.77259671021627 0.0786028028543009 no 345 0.0381477786268797 278 900724 SGTC_1072 oxiconazole 14.9 nM 1.77091789001207 0.0788103573937721 no 346 0.0382871784624875 336 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_233 rapamycin 362 pM 1.76917911052333 0.0790257622484055 no 347 0.0384319945523598 282 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_6 0844-0013 19.835 µM 1.76534980165243 0.0795017196637012 no 348 0.0387524972039446 565 1584900 SGTC_3075 9116269 49.47 µM 1.76299460275778 0.079795530619686 no 349 0.0389506999813008 271 17015205 YNL244C SUI1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.7622895920654 0.0798836401939689 no 350 0.0390101907348441 342 676296 Flavone; oxidizing agent. SGTC_3025 9087895 49.47 µM 1.75838791168763 0.080372588249235 no 351 0.0393407642738192 304 17173641 SGTC_2942 9052777 62.25 µM 1.75774719438383 0.0804530969163971 no 352 0.0393952669103914 345 6469503 SGTC_1778 st046819 58.9 µM 1.75636338515064 0.0806271859038565 no 353 0.039513190312271 357 671715 SGTC_3009 9080819 71.4286 µM 1.75476271402874 0.0808289117383068 no 354 0.0396499518966751 278 17027216 SGTC_2652 actinonin 100 µM 1.75386341101107 0.0809424141677795 no 355 0.0397269572093017 222 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1501 4491-0275 38.4 µM 1.75244401761989 0.0811218027514128 no 356 0.0398487440778492 265 5104718 SGTC_2220 6782180 200 µM 1.74443417826554 0.0821397456393683 no 357 0.0405417047935783 190 833803 SGTC_2584 androsterone 48.74 µM 1.74422177808419 0.0821668692107859 no 358 0.040560212617662 480 2754130 A steroid. SGTC_3340 9146634 11.102 µM 1.74312857353746 0.0823065785138586 no 359 0.0406555792376739 282 4907387 SGTC_914 3820-6779 408 µM 1.74270891444679 0.0823602575779777 no 360 0.0406922368569802 305 2893481 SGTC_260 nsc-65238 3.989 µM 1.74268878811514 0.0823628326218839 no 361 0.0406939955849684 265 3246252 SGTC_133 0724-0033 378.92 µM 1.7357694412193 0.0832517195046511 no 362 0.0413023047297518 285 280309 SGTC_1898 st060199 18.6 µM 1.73117297230864 0.0838461748421448 no 363 0.0417104591888552 277 688866 SGTC_1646 st011709 75.6 µM 1.7296328591904 0.0840460670511246 no 364 0.0418479456825478 245 5757843 SGTC_2001 4023502 57.655 µM 1.72811896510444 0.0842429047753372 no 365 0.0419834490066381 330 108941 YCR052W RSC6 SGTC_2673 kobusone 100 µM 1.72694113566412 0.0843962862628447 no 366 0.0420891178527042 229 6710676 An epoxy ketone and protein crosslinker. SGTC_1848 st056003 16.4 µM 1.72586608902219 0.0845364658034103 no 367 0.0421857533531625 314 146492 SGTC_206 4546-0025 72.014 µM 1.72546885458921 0.084588306925419 no 368 0.0422215059886329 388 6620745 YIL048W NEO1 SGTC_156 3474-0145 5.642 µM 1.71354543065204 0.086155496255519 no 369 0.0433061214538268 339 2265471 SGTC_2877 9040724 71.43 µM 1.71257299152417 0.0862842632347887 no 370 0.0433955628028921 278 6463895 SGTC_2991 9074669 71.4286 µM 1.70864300918224 0.0868061241763251 no 371 0.0437585483624424 385 17333109 SGTC_266 formosanin C 406 nM 1.70845127175883 0.08683164512652 no 372 0.0437763203174565 358 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1649 st011737 51.3 µM 1.70503519842393 0.0872872771113877 no 373 0.0440939299901252 308 1761035 SGTC_1904 st060225 78 µM 1.70369544834186 0.0874664579309943 no 374 0.0442189994674036 302 66595 SGTC_1068 loratadine 26.9 µM 1.70291072142266 0.0875715362665966 no 375 0.0442923886537448 309 3957 A H1 histamine antagonist. SGTC_846 0335-0850 148 µM 1.70196621404227 0.0876981347863155 no 376 0.0443808509712228 281 6819598 SGTC_2984 9022109 38.96 µM 1.70116855924413 0.0878051559964226 no 377 0.0444556699553653 228 6459207 SGTC_2728 chlorpromazine 9.18 µM 1.69876055374736 0.088128828621405 no 378 0.0446821544000929 202 2726 A thorazine and dopamine antagonist. SGTC_2733 amorolfine 100 µM 1.69518506357139 0.0886110686598916 no 379 0.045020159731682 178 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3274 9138298 49.47 µM 1.69206943716546 0.0890328853740252 no 380 0.045316367490285 351 17015756 SGTC_3237 9133362 49.47 µM 1.69023536001329 0.0892818942722418 no 381 0.0454914680138717 322 43845137 SGTC_1944 st076371 56.9 µM 1.68930607161452 0.0894082594601062 no 382 0.0455803952201594 335 24208455 SGTC_2248 tofa 1.1 µM 1.68841195913541 0.089529966936965 no 383 0.0456660881843756 297 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_857 0438-0306 1.35 µM 1.68830885017928 0.0895440101499404 no 384 0.0456759786111347 321 4686136 SGTC_1299 1079-1439 3.74 µM 1.68519895496255 0.0899683411872353 no 385 0.045975096316292 304 323161 SGTC_1951 sophoraflavanone G 9.2 µM 1.68193448306763 0.0904153691162063 no 386 0.0462907725507728 361 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3112 9123419 49.47 µM 1.68040492109763 0.0906253897232127 no 387 0.0464392796169071 360 17015854 SGTC_1801 st050089 28.441 µM 1.68038315567906 0.0906283808931915 no 388 0.0464413956048388 459 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1814 st052110 31.539 µM 1.67333503104946 0.0916008464091793 no 389 0.0471306799358967 306 674163 SGTC_1358 1509-0022 2.48 µM 1.66811068924532 0.0923266499780886 no 390 0.0476468778077889 335 3258434 SGTC_2383 9036125 200 µM 1.66671843745472 0.0925207880522804 no 391 0.0477852024851252 268 79580 SGTC_1713 st033146 12.748 µM 1.66562683844875 0.0926732136647011 no 392 0.0478938810743493 354 674619 SGTC_2382 9035899 200 µM 1.66540682192458 0.0927039581868592 no 393 0.047915809657838 344 6462679 SGTC_308 4092-1169 104 µM 1.65572981801351 0.0940636698120245 no 394 0.0488882729905178 378 2268590 YDL196W YDL196W SGTC_1594 piperine 70.1 µM 1.65409302191428 0.0942951028876887 no 395 0.0490543068547504 369 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_291 SEC14.278 35.5 µM 1.64916753462691 0.0949940700553005 no 396 0.0495566585264606 343 1068044 SGTC_1091 telmisartan 47.6 µM 1.64887289278258 0.0950360028197973 no 397 0.0495868387895952 350 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2826 7992541 19.48 µM 1.64819686237079 0.0951322654738216 no 398 0.0496561402473288 346 2985066 SGTC_358 0075-0058 9.45 µM 1.64791914086199 0.0951718321446756 no 399 0.0496846325146574 459 1069125 SGTC_2731 amoxapine 43.43 µM 1.64649412162604 0.0953750436667816 no 400 0.0498310346753538 171 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1473 k844-0725 134 µM 1.64630221175103 0.095402434910291 no 401 0.0498507771792287 377 54682906 SGTC_1662 st014054 52 µM 1.64094271381616 0.0961697352841863 no 402 0.0504046536494469 283 2838777 SGTC_2784 7567673 72.73 µM 1.6384115433398 0.0965336872265607 no 403 0.0506679363832398 395 3471247 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.63514307458867 0.0970051494503208 no 404 0.0510095290918919 339 6708514 SGTC_2793 7325131 81.82 µM 1.63434227828715 0.0971209181534829 no 405 0.0510935004958576 330 4176441 SGTC_2045 5106652 78.05 µM 1.63269505879909 0.0973593704451833 no 406 0.0512665735912256 327 673349 SGTC_1934 st074720 32.6 µM 1.63118218088569 0.0975787535103821 no 407 0.0514259420408606 423 17250992 SGTC_3308 9128332 17.569 µM 1.63098259886789 0.0976077220281314 no 408 0.0514469956469668 460 17332805 YDL196W YDL196W SGTC_3306 9127676 59.7925 µM 1.62791212780085 0.0980541834889027 no 409 0.0517717597340542 355 41905287 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.62766740155369 0.0980898321564579 no 410 0.0517977144140295 252 4620898 SGTC_1826 st055655 41.6 µM 1.62637967720229 0.0982775682297624 no 411 0.0519344556912077 373 676168 SGTC_1301 naphtanilide LB 4.81 µM 1.61699254220314 0.0996540664009719 no 412 0.0529399453710924 362 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2736 butenafine 14.65 µM 1.61655020440605 0.0997192751426129 no 413 0.0529877040343616 409 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_695 3505-6186 243 µM 1.61309263560146 0.100230058946717 no 414 0.0533621917954605 346 1819379 SGTC_1903 st060211 78.3 µM 1.61216177870025 0.100367899397419 no 415 0.0534633700473044 385 688960 SGTC_3053 9095903 49.47 µM 1.61128848699699 0.100497341367139 no 416 0.0535584294706122 314 17174018 SGTC_704 1310-0270 142 µM 1.6016074152501 0.101940465771692 no 417 0.0546212250149064 409 5718033 SGTC_2493 resveratrol 26.09 µM 1.59926436607696 0.102291991801511 no 418 0.0548809368602925 291 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_27 0485-0001 32.618 µM 1.59767828435117 0.102530450414622 no 419 0.0550572970209414 254 2054479 SGTC_3113 9123498 49.47 µM 1.59299182915597 0.103237393691121 no 420 0.055581012031207 343 8897275 SGTC_278 4092-0821 23.9 µM 1.59188490210396 0.103404887127275 no 421 0.0557052842664405 359 877900 SGTC_492 tmb-8 126 µM 1.59066260913845 0.103590066095774 no 422 0.0558427630127889 199 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1207 2099-0101 141 µM 1.58940644456094 0.103780627274441 no 423 0.0559843302870369 409 5837381 SGTC_1065 prochlorperazine maleate 2.48 µM 1.58934307135837 0.103790247774058 no 424 0.0559914798162202 392 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2725 haloperidol 53.21 µM 1.58862528815435 0.103899257494759 no 425 0.0560725077305751 376 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2051 5263410 176 µM 1.58690949357127 0.104160171614289 no 426 0.0562665722301183 374 227584 SGTC_168 3970-0862 530.542 µM 1.58224112713192 0.104872475259175 no 427 0.0567972674445352 601 3135186 SGTC_1839 st053978 48 µM 1.57492817665798 0.105995370589623 no 428 0.0576365119866651 373 3788398 SGTC_3235 9132602 49.47 µM 1.56709793888031 0.107207298370347 no 429 0.058545900453805 420 4912240 SGTC_2013 4024628 200 µM 1.56551494348792 0.107453516413318 no 430 0.0587311081419264 393 5230760 SGTC_1788 fluconazole 20 µM 1.56307632226022 0.107833615038842 no 431 0.0590173220609362 390 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1550 gossypolone 36.6 µM 1.56138926063217 0.108097137037165 no 432 0.0592159671187974 402 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3099 9120367 49.47 µM 1.55790965127467 0.108642121722329 no 433 0.0596273335138932 388 24824940 SGTC_822 1487-0950 154 µM 1.55675947195413 0.108822699378649 no 434 0.0597638013859075 376 1958375 SGTC_2850 9015429 58.44 µM 1.54958000079922 0.109954752201004 no 435 0.0606211780948848 366 6457570 SGTC_796 1234-0020 70.7 µM 1.549107065203 0.110029619844278 no 436 0.0606779923921934 409 46495034 SGTC_774 k060-0086 136 µM 1.54846183114986 0.110131822018529 no 437 0.0607555722618308 453 5911235 SGTC_2266 7929956 200 µM 1.54510962013428 0.110663893176352 no 438 0.061159875218652 423 2967153 SGTC_261 5-fluorouridine 15.376 µM 1.54472019533403 0.110725822869928 no 439 0.0612069789028522 393 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3174 9107204 49.47 µM 1.54458952090011 0.110746609410442 no 440 0.0612227912507137 395 3938802 SGTC_1019 4262-0212 3.4 µM 1.54157095884943 0.111227554280582 no 441 0.0615889436113266 482 4677213 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.54146657419863 0.111244212504303 no 442 0.0616016360197816 375 756377 SGTC_2337 9009472 200 µM 1.54041477478939 0.111412163584152 no 443 0.0617296411251085 444 5742383 SGTC_1917 st066507 28.5 µM 1.54033650346329 0.111424669182147 no 444 0.0617391751240201 467 3156428 SGTC_2108 5365811 200 µM 1.53995014783463 0.111486412868719 no 445 0.0617862528041749 403 780283 SGTC_1212 0520-0165 585 µM 1.53989532877901 0.111495175512562 no 446 0.0617929348106358 418 5403258 SGTC_2351 9026858 72.31 µM 1.53927924440537 0.111593688448486 no 447 0.0618680693906935 364 1409300 SGTC_377 3970-0964 33.1 µM 1.53911395157736 0.111620129644701 no 448 0.0618882398071866 500 16481235 SGTC_2755 lomerizine 42.69 µM 1.53898762111967 0.111640341216766 no 449 0.0619036591686877 423 3949 A calcium channel blocker. SGTC_1772 st048439 82.2 µM 1.53706728062027 0.111947898374425 no 450 0.062138417181181 423 2927068 YDL195W SEC31 SGTC_1319 1306-0155 43.7 µM 1.53624425409998 0.112079897642828 no 451 0.0622392429993658 448 3122360 SGTC_2487 5918373 44.05 µM 1.53094501124378 0.112932469841867 no 452 0.062891491765282 404 2876279 SGTC_1002 4049-0206 172 µM 1.52461649769905 0.113956689693524 no 453 0.0636773900196923 459 4662749 SGTC_660 4031-1742 102 µM 1.52403783329859 0.11405067114292 no 454 0.0637496302806743 461 6738706 SGTC_818 4072-2707 53.5 µM 1.52215082370045 0.114357525776332 no 455 0.0639856468774009 354 882871 SGTC_1699 st031318 29.054 µM 1.51937531368878 0.114809930640027 no 456 0.0643340260732816 408 5340658 SGTC_160 3453-0671 289.699 µM 1.51826867705027 0.114990665682107 no 457 0.0644733403055768 431 5322268 SGTC_2690 usnic acid 100 µM 1.51775636393566 0.115074404749721 no 458 0.0645379146033911 486 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1697 st025554 27.742 µM 1.5162501082683 0.115320857752112 no 459 0.0647280610107421 370 1269519 SGTC_586 0957-0265 8.15 µM 1.51555113062546 0.115435351570627 no 460 0.064816446066817 331 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2393 9031399 185.94 µM 1.51550958127957 0.115442159972289 no 461 0.0648217028912021 419 1526623 YDL150W RPC53 SGTC_741 4582-0002 126 µM 1.51503077184879 0.115520639728224 no 462 0.0648823057638504 410 2912688 SGTC_1519 esterone 74 µM 1.51374422431086 0.115731700385353 no 463 0.0650453618765442 421 698 A steroid. SGTC_1162 k048-0130 20.1 µM 1.5087126496339 0.116559769850013 no 464 0.0656861157419386 403 6797406 SGTC_1127 asiatic acid 681.4 nM 1.50846452604355 0.116600713132633 no 465 0.0657178395891685 428 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2571 chrysanthemic acid 100 µM 1.50811395089938 0.116658579498575 no 466 0.0657626826265765 389 2743 An insecticide. SGTC_505 gw-5074 63.9 µM 1.50305321096243 0.117496180864553 no 467 0.0664126614891333 434 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.50270661600344 0.117553701076564 no 468 0.0664573579484653 486 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_43 0570-0105 72.5 µM 1.50182396635581 0.117700273879543 no 469 0.066571288532604 543 1114046 YDL195W SEC31 SGTC_1665 st014639 11.4 µM 1.50040524313201 0.117936138017765 no 470 0.0667547311031731 467 981133 YIL048W NEO1 SGTC_711 k292-0785 179 µM 1.49597407692893 0.118674976359836 no 471 0.0673302053258405 414 4146315 SGTC_1621 st003705 32.4 µM 1.49549606305468 0.118754873836008 no 472 0.067392513307647 465 24207032 SGTC_2938 9059746 27.26 µM 1.49105756769228 0.119498559527176 no 473 0.0679731907164967 391 6471769 SGTC_1768 st044301 37.178 µM 1.48934526968305 0.119786337576415 no 474 0.0681982363268085 429 3931349 SGTC_3342 9147791 14.508 µM 1.48778130620222 0.120049612419178 no 475 0.0684042885877652 418 1838168 SGTC_2239 6685329 187.64 µM 1.48547386857804 0.120438786654539 no 476 0.068709170301536 443 805680 SGTC_2785 7756463 72.73 µM 1.47911800755351 0.121515363024967 no 477 0.0695543890942247 431 2201551 SGTC_251 melphalan 456.522 µM 1.47798102242593 0.121708660324882 no 478 0.0697064289369667 502 460612 A DNA alkylator. SGTC_2380 9035439 200 µM 1.47773316606586 0.121750826717066 no 479 0.069739606706505 494 6462575 SGTC_3355 9151058 44.0485 µM 1.47602015108753 0.122042532836104 no 480 0.0699692413458042 422 17015728 SGTC_1034 k072-0165 12.7 µM 1.47251980183552 0.122640126065209 no 481 0.0704402818624468 462 5835461 SGTC_3317 9138495 8.753 µM 1.4708313317048 0.122929120976008 no 482 0.0706683684366298 449 17020139 SGTC_147 4466-0538 29.23 µM 1.47057612881195 0.122972842457396 no 483 0.0707028917769351 470 6742687 YHR072W ERG7 SGTC_3055 9094636 49.47 µM 1.46600660646231 0.123757540902034 no 484 0.071323243530762 404 25236176 SGTC_2801 7907800 81.82 µM 1.46571943291927 0.123806972415477 no 485 0.0713623688961227 462 6620925 SGTC_1670 st016595 4.04 µM 1.46549905279066 0.123844916073477 no 486 0.0713924053014057 449 597879 SGTC_949 1165-0505 146 µM 1.46510336733764 0.123913063120859 no 487 0.0714463590537325 482 6244267 SGTC_2150 5556613 200 µM 1.46477068349537 0.12397038000298 no 488 0.0714917464224501 470 743190 SGTC_944 3370-0224 231 µM 1.46399778650685 0.12410361121403 no 489 0.0715972765708785 442 4580514 SGTC_1502 4534-4282 27.7 µM 1.46324947014209 0.124232700662069 no 490 0.0716995643563627 394 3278949 SGTC_1371 2421-0008 32.7 µM 1.46233281632554 0.124390957373951 no 491 0.0718250150028224 456 2827552 SGTC_3077 9117319 49.47 µM 1.4594776155092 0.124884799911044 no 492 0.0722168486127499 372 17154678 SGTC_3301 9125354 19.7965 µM 1.45742990704089 0.125239819017653 no 493 0.0724988732979828 397 41905162 SGTC_906 1165-0455 526 µM 1.45503203831616 0.125656441737428 no 494 0.0728301960569213 425 3252859 SGTC_3213 9129884 49.47 µM 1.45315639553319 0.125983002518049 no 495 0.0730901679005827 379 17190742 SGTC_351 caspofungin 25 nM 1.44738077133227 0.12699228854873 no 496 0.0738951541006459 599 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.4465835920589 0.127132035782294 no 497 0.0740067921981741 415 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1724 st037281 8.293 µM 1.44586778216663 0.127257609938512 no 498 0.0741071449742899 483 574124 YDL195W SEC31 SGTC_2772 vinpocetine 57.06 µM 1.44209717055435 0.127920510664268 no 499 0.0746374815811496 448 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_969 1313-0238 134 µM 1.44076302959986 0.128155635921663 no 500 0.0748258206816154 507 5212874 SGTC_332 4112-0506 40.9 µM 1.43931627276082 0.128410947331322 no 501 0.0750304671875798 449 2790355 SGTC_2555 cholic acid 100 µM 1.43011086306849 0.130043710507066 no 502 0.0763426014429783 434 6708657 Influences liver metabolism. SGTC_1997 st073024 93.8 µM 1.42712534297506 0.130576324691387 no 503 0.0767718843925189 442 686268 SGTC_3057 9095946 49.47 µM 1.42283699171711 0.131343999044369 no 504 0.0773917075507646 449 24540043 SGTC_3172 9105863 49.47 µM 1.41967423750698 0.131912168906146 no 505 0.0778512708289766 343 2348785 SGTC_487 nimodipine 119 µM 1.41556957660548 0.132652071271815 no 506 0.0784507820263578 333 4497 L-type voltage-gated calcium channels inhibitor SGTC_1897 st060201 15 µM 1.41272244353477 0.133166968981733 no 507 0.078868674919193 424 611878 SGTC_1824 st053723 68.6 µM 1.4117882910413 0.133336207666491 no 508 0.0790061535628078 479 675225 SGTC_1195 1502-0147 41.1 µM 1.41071961659899 0.133529998840676 no 509 0.0791636522264458 501 817940 SGTC_1657 st012939 43.4 µM 1.40681395198354 0.134239890939704 no 510 0.0797412821599458 431 24207257 SGTC_71 0417-1750 47.813 µM 1.40452845353683 0.134656502376755 no 511 0.0800807724453633 507 6811472 SGTC_187 1488-2104 32.728 µM 1.40027801347408 0.135433650230558 no 512 0.0807150410812304 493 2852859 SGTC_1416 3966-0321 25.3 µM 1.39575216666017 0.136264526162733 no 513 0.0813945695743416 498 582530 YLR208W SEC13 SGTC_1316 1272-0050 65.9 µM 1.39495517762428 0.136411201522485 no 514 0.0815146781917732 468 7340392 SGTC_1249 0481-0015 10.2 µM 1.39024138048405 0.137280922071056 no 515 0.0822277958334487 415 4227577 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.38573092364869 0.138116663681356 no 516 0.0829145409364369 517 688801 SGTC_1107 amlodipine 47 µM 1.38486336603711 0.138277810254459 no 517 0.0830471253235434 501 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_951 1171-0579 82.7 µM 1.3830852861152 0.138608484391518 no 518 0.0833193583692857 581 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1224 0823-0416 294 µM 1.38077024447045 0.139039825440624 no 519 0.0836748076081894 489 3598164 SGTC_3131 9127911 49.47 µM 1.37970135198083 0.139239290662171 no 520 0.0838393082407431 488 45595681 SGTC_2889 9059656 51.95 µM 1.37760967602892 0.139630179847088 no 521 0.0841619159402098 521 3949838 SGTC_2875 9039966 71.43 µM 1.37548927985758 0.140027197163141 no 522 0.084489903481998 433 6463691 SGTC_964 1287-0107 19.4 µM 1.37371903395204 0.140359240236268 no 523 0.084764462718216 543 51516812 YPR165W RHO1 SGTC_3033 9090887 49.47 µM 1.36775519195437 0.141481804009723 no 524 0.0856943587961747 531 19325384 SGTC_2197 6588183 93.1375 µM 1.36662350466407 0.141695504435666 no 525 0.0858716729662587 439 884136 SGTC_3318 9139014 38.6185 µM 1.36504075003717 0.141994748021716 no 526 0.0861201212971229 464 16643984 SGTC_575 k072-0246 11.9 µM 1.36382607240649 0.142224691067053 no 527 0.0863111562191102 521 6796779 SGTC_1 0258-0098 57.368 µM 1.36300877639081 0.142379550010038 no 528 0.0864398723319499 430 6790032 YDR047W HEM12 SGTC_923 1900-2434 73.3 µM 1.3600577014356 0.142939660630762 no 529 0.086905832507754 488 5910570 SGTC_1437 4092-1038 11.6 µM 1.35748025621878 0.143430073375193 no 530 0.0873143313554214 528 3977136 SGTC_2470 5664817 21.68 µM 1.35713259010779 0.143496310955274 no 531 0.087369542436421 479 2859561 SGTC_721 1187-1332 279 µM 1.35368038444515 0.14415514798602 no 532 0.0879191844257911 407 25730 SGTC_1008 4106-0037 6 µM 1.35112259209377 0.144644603837886 no 533 0.0883280827801155 485 2905394 SGTC_1311 1190-0148 100 µM 1.34934379931952 0.144985650546676 no 534 0.0886132817082951 617 1961333 SGTC_3141 9094609 49.47 µM 1.34760102464444 0.145320316114273 no 535 0.0888933704283714 494 25236309 YDL196W YDL196W SGTC_1413 3910-0535 34.4 µM 1.33691069382337 0.147384549392443 no 536 0.0906258948697674 517 2876951 SGTC_708 3448-5400 146 µM 1.33687817429467 0.147390858530489 no 537 0.0906312031021483 558 3462195 SGTC_215 1287-0124 461.5 µM 1.33637280802005 0.147488928278841 no 538 0.0907137247853935 426 5560863 SGTC_3268 9137683 49.47 µM 1.33568715996224 0.147622052807175 no 539 0.0908257739656021 458 1953228 SGTC_2741 miltefosine 3.04 µM 1.33500102363327 0.147755352683845 no 540 0.0909380057120985 421 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2556 citropten 84.59 µM 1.33416466181562 0.147917946754027 no 541 0.0910749490328656 573 2775 A potential DNA crosslinker. SGTC_1581 himbacine 57.9 µM 1.33274708339939 0.148193806497633 no 542 0.091307408204566 545 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1806 st050005 60.3 µM 1.33221528155834 0.148297383486958 no 543 0.0913947281900841 519 5194765 SGTC_830 4076-0286 57.8 µM 1.32654762832738 0.149404258351357 no 544 0.0923291849790902 687 6866659 SGTC_83 0170-0301 39.027 µM 1.32604005608003 0.149503653984046 no 545 0.0924132148933097 387 3089716 SGTC_3243 9134147 49.47 µM 1.32108058167857 0.150477168016524 no 546 0.0932372485092225 527 24282180 SGTC_2895 9054447 58.44 µM 1.31866015405885 0.150953812940818 no 547 0.0936413767518554 490 2697450 SGTC_1695 st026914 34.495 µM 1.31702103652258 0.151277167711734 no 548 0.0939157866371485 542 3289191 SGTC_1017 4239-0030 168 µM 1.31546940245945 0.151583688475145 no 549 0.0941760970176606 572 1149593 SGTC_276 colchicine 750 µM 1.31387329515313 0.151899425288652 no 550 0.0944444234248521 570 2833 A microtubule depolymerizer. SGTC_743 1275-0778 158 µM 1.31334048907814 0.152004920470386 no 551 0.0945341204373514 561 2849257 YMR203W TOM40 SGTC_2948 9070189 9.45 µM 1.31314246659602 0.152044141166853 no 552 0.0945674731947224 473 6473636 YDL196W YDL196W SGTC_2284 7945075 39.21 µM 1.31115325423024 0.152438501075626 no 553 0.0949029958983941 609 1245402 SGTC_1078 idebenone 36.1 µM 1.31048504526797 0.152571125196482 no 554 0.0950159000226753 607 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_724 3910-0327 137 µM 1.30907128780127 0.152851975823694 no 555 0.095255102029677 552 2885483 SGTC_2050 5263056 171 µM 1.30875763768976 0.152914330564755 no 556 0.0953082303966954 625 763468 YGL055W OLE1 SGTC_1387 3342-1166 1.8 µM 1.3086383851145 0.152938042819286 no 557 0.0953284359998467 461 3418228 SGTC_649 1123-0311 367 µM 1.30842276656641 0.152980922731115 no 558 0.0953649774120986 599 693629 YIL048W NEO1 SGTC_995 3931-2021 34.6 µM 1.30267377225284 0.154127160555278 no 559 0.0963430799524667 517 730143 SGTC_2561 acetosyringone 100 µM 1.29382918860977 0.155901664445716 no 560 0.0978622140527929 623 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1354 1498-1681 81 µM 1.29209680717368 0.156250806194677 no 561 0.0981618107379641 592 5754243 SGTC_761 k216-0224 480 µM 1.29064157799856 0.156544488833748 no 562 0.0984139957532586 598 1340404 SGTC_3234 9132280 49.47 µM 1.29019043860836 0.156635607904549 no 563 0.0984922725402114 579 17612295 SGTC_2943 9068529 45.32 µM 1.28832082280937 0.15701359643242 no 564 0.0988171537984279 598 3270634 SGTC_457 grayanotoxin iii 135 µM 1.2836677806508 0.157956925342432 no 565 0.0996291112155815 632 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1694 st024011 44.9 µM 1.27879611513109 0.15894855588986 no 566 0.100484431159634 609 2787533 SGTC_1166 k206-0078 225 µM 1.27578554174608 0.159563395044822 no 567 0.101015669943888 605 5404595 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.27355637547045 0.160019651762936 no 568 0.101410340545454 494 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1218 1348-1416 30.7 µM 1.27300448294609 0.160132742511721 no 569 0.101508225540934 572 6787668 SGTC_1193 1488-0126 41.5 µM 1.27176278763568 0.160387374799805 no 570 0.101728707166257 561 1384710 SGTC_1186 1319-0216 26 µM 1.27173132066181 0.160393831112744 no 571 0.101734299125572 604 4565136 SGTC_44 0929-0055 61.211 µM 1.27062151798255 0.160621646193537 no 572 0.101931664018924 527 1379590 SGTC_728 3030-5151 22.5 µM 1.26959067638811 0.160833441743513 no 573 0.102115236131518 526 3125388 SGTC_3094 9117742 49.47 µM 1.2686589472031 0.161025030575392 no 574 0.102281365164473 607 17149698 SGTC_994 3910-0338 138 µM 1.26616313084297 0.161538971774343 no 575 0.102727342175704 602 3479481 SGTC_1341 1486-1360 280 µM 1.26572234552269 0.161629849756933 no 576 0.102806252645675 578 3976547 SGTC_2987 9018338 71.43 µM 1.26497446068745 0.161784119560977 no 577 0.102940241576765 583 5055682 SGTC_326 k292-0812 17.5 µM 1.26355521975591 0.162077136940481 no 578 0.103194857487266 549 3579357 SGTC_1146 3579-1023 7 µM 1.26338075916892 0.162113180023378 no 579 0.1032261877547 631 X1146 SGTC_1868 st057644 42.7 µM 1.26220049184424 0.162357157138668 no 580 0.103438325892849 604 688665 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.2614681861743 0.162508654646778 no 581 0.103570107562997 594 5282309 SGTC_3228 9131799 49.47 µM 1.25682653291779 0.163471046469209 no 582 0.104408228027777 561 17015818 SGTC_1252 0493-0875 34.8 µM 1.2563953344347 0.163560637892678 no 583 0.104486336181596 564 3960963 SGTC_220 paclitaxel 373.376 µM 1.25587704964209 0.163668365689433 no 584 0.104580275337084 515 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_61 0978-8327 98.565 µM 1.25252781235012 0.164365629894323 no 585 0.105188800211911 600 6150059 YHR072W ERG7 SGTC_2848 9016370 25.97 µM 1.25130937605011 0.164619768271827 no 586 0.105410813006381 656 7894410 SGTC_3354 9151612 71.43 µM 1.24788907583802 0.165334525673917 no 587 0.106035840872958 629 27261949 SGTC_528 3492-0019 172 µM 1.24217526599679 0.166533041668934 no 588 0.107085951676312 805 2869262 SGTC_70 0141-0289 43.283 µM 1.24186104362012 0.166599114540399 no 589 0.107143917747613 807 352408 SGTC_1322 1348-1070 12 µM 1.23970118000176 0.167053735993398 no 590 0.107542970271481 546 6758089 SGTC_26 0302-0163 425.158 µM 1.23938026260938 0.167121352868235 no 591 0.107602353664864 587 3100915 SGTC_3046 9092212 49.47 µM 1.23917900960088 0.16716376561545 no 592 0.107639606100346 568 25236637 SGTC_2419 paclitaxel 166.5 µM 1.2375854566905 0.167499841383775 no 593 0.107934904858316 645 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1191 1487-1166 10.6 µM 1.23746882977421 0.167524454751277 no 594 0.107956539695374 688 3955771 SGTC_594 1487-1584 10.8 µM 1.23574550380046 0.167888423279813 no 595 0.108276588755866 597 5013332 SGTC_3344 9148862 3.898 µM 1.23447278681171 0.168157549194997 no 596 0.108513390544741 599 4905352 SGTC_3331 9141060 1.957 µM 1.23442791309669 0.168167043154425 no 597 0.108521746544754 555 4906567 YPR165W RHO1 SGTC_2841 9004761 38.96 µM 1.23366862701959 0.168327738059669 no 598 0.108663204499382 526 2991039 SGTC_2865 9030313 51.95 µM 1.23102878198842 0.168887201774137 no 599 0.109156049856091 535 42562754 SGTC_3072 9116419 49.47 µM 1.23036356560894 0.169028369653021 no 600 0.109280495286592 518 17170162 SGTC_3289 9119912 71.43 µM 1.22867234514738 0.169387610576099 no 601 0.109597339445388 582 17014829 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.22849649031032 0.169424992920465 no 602 0.109630323046336 680 5024745 SGTC_863 0466-0191 129 µM 1.22782891274318 0.169566951424686 no 603 0.109755599791888 650 765160 YPR165W RHO1 SGTC_3091 9116372 49.47 µM 1.22263766414433 0.170673458815214 no 604 0.110733290381129 546 17169793 SGTC_2581 avocatin a 64 µM 1.22037203696669 0.171157819600276 no 605 0.111161936388768 640 6710728 A skin care supplement. SGTC_647 0140-0236 81 µM 1.22018765463067 0.171197276720488 no 606 0.111196872867924 680 990837 SGTC_787 4152-0075 138 µM 1.22002905087921 0.171231221974528 no 607 0.111226931150022 584 9566539 SGTC_3002 9075603 71.4286 µM 1.21847685100958 0.171563659525364 no 608 0.11152140821166 633 20105405 SGTC_2436 5633522 8.09 µM 1.21836961751797 0.17158664114225 no 609 0.111541772697625 632 5724242 SGTC_1028 k015-0029 4.8 µM 1.21782661606905 0.171703044041092 no 610 0.111644933808556 631 4588309 SGTC_2400 5203494 178.7 µM 1.21571525804832 0.172156133858032 no 611 0.112046704871237 571 6777674 SGTC_1148 3909-7663 27.7 µM 1.21442229851482 0.172433974669531 no 612 0.112293252332036 627 4084526 SGTC_3006 9075424 71.4286 µM 1.2135572242845 0.172620027890514 no 613 0.112458424972016 574 7465181 SGTC_1789 tunicamycin 25 nM 1.2124480568829 0.172858765900133 no 614 0.11267045729122 598 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1338 1486-1223 76 µM 1.21048371100069 0.173282089191952 no 615 0.113046668733763 649 3444526 SGTC_3197 9113331 49.47 µM 1.21043166482728 0.173293314290292 no 616 0.113056648791089 612 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_507 nimesulide 162 µM 1.20867112301918 0.173673293185118 no 617 0.113394610001059 624 4495 A COX2 inhibitor. SGTC_2658 polymyxin b sulfate 77.05 µM 1.20865486809913 0.17367680396305 no 618 0.113397733719136 642 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1933 st074711 15.9 µM 1.20834136264485 0.173744524481336 no 619 0.113457992263602 658 17250958 SGTC_1075 aripiprazole 15.2 µM 1.20799254903157 0.173819891676768 no 620 0.113525064184689 662 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1564 D-Arginine 115 µM 1.20752394746344 0.173921173850664 no 621 0.113615214130663 596 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_452 diindolylmethane 8 µM 1.20723593910051 0.17398344175334 no 622 0.113670646728112 558 3071 Inhibits expression of several cancer promoting factors. SGTC_315 k915-0449 187 µM 1.20600950137312 0.174248758364632 no 623 0.113906913460946 702 20970215 YNL149C PGA2 SGTC_2386 9075165 157.42 µM 1.20568439328024 0.174319132440823 no 624 0.113969602446243 594 16452277 SGTC_1905 st060207 84.5 µM 1.20434737397113 0.174608738296601 no 625 0.114227671675579 616 1948547 SGTC_1597 7-benzyloxygramine 47.5 µM 1.20197758607515 0.175122797774235 no 626 0.114686106132152 735 260807 SGTC_3276 9139060 49.47 µM 1.20158762845822 0.175207480108345 no 627 0.114761668532588 567 4870619 SGTC_615 k087-0205 167 µM 1.20123645298845 0.175283762817614 no 628 0.114829746391602 599 9642773 SGTC_3050 9093513 49.47 µM 1.19581590941497 0.176463889464203 no 629 0.115884203028739 613 25236664 SGTC_2448 5185112 27.17 µM 1.19556944962542 0.176517666324699 no 630 0.115932309650325 560 5718189 SGTC_1264 0783-0040 158 µM 1.1949821445128 0.176645856489608 no 631 0.116047003204491 574 2855798 SGTC_860 0443-0016 25.1 µM 1.19447310573333 0.176757011193568 no 632 0.116146477435272 622 5337942 SGTC_1837 st055472 66.5 µM 1.19103830341918 0.177508196732855 no 633 0.116819274160792 620 676091 SGTC_94 0334-0113 514.748 µM 1.19000444366958 0.177734694095851 no 634 0.117022322753256 616 6795178 SGTC_1833 st055984 71 µM 1.18927047549778 0.177895602014254 no 635 0.11716662477819 622 676288 SGTC_2997 9067075 71.4286 µM 1.18744231488806 0.178296789117247 no 636 0.117526598729822 669 27209819 SGTC_1046 2001-0062 216 µM 1.18719278929608 0.178351591319931 no 637 0.117575792228106 622 739778 SGTC_1588 farnesol 29.9 µM 1.18687664613792 0.178421039684257 no 638 0.117638140184868 636 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_609 0986-0026 86.3 µM 1.1837575668366 0.179107132594724 no 639 0.11825452190738 650 2848610 SGTC_970 1315-0089 19.5 µM 1.18322271119198 0.179224949399192 no 640 0.118360447183615 597 6811083 YLR033W RSC58 SGTC_3003 9075612 71.4286 µM 1.18288350304169 0.179299694664475 no 641 0.118427660277174 629 6501993 SGTC_2940 9060638 45.86 µM 1.18201856192453 0.179490375052723 no 642 0.118599167895795 636 4027022 SGTC_1947 st076332 61.6 µM 1.18046825871714 0.179832465628493 no 643 0.118907013791033 579 24208416 SGTC_3160 9100216 49.47 µM 1.17994843681537 0.179947261375812 no 644 0.119010361782894 645 17191039 SGTC_3056 9094900 49.47 µM 1.17861210856436 0.180242582836061 no 645 0.119276333914759 608 25236784 SGTC_1334 1486-0610 236 µM 1.17679158561023 0.180645397912406 no 646 0.119639350955063 663 3742339 SGTC_140 0062-0056 502.533 µM 1.17349987784704 0.18137516412747 no 647 0.120297702913417 676 3758964 SGTC_875 0709-0210 25.7 µM 1.17254132995227 0.181588019156678 no 648 0.12048989442716 685 6251364 SGTC_1429 4049-0205 9.46 µM 1.17010322459459 0.182130128685217 no 649 0.120979715488867 699 22774478 SGTC_145 3737-0113 38.366 µM 1.16984799974512 0.182186936032711 no 650 0.121031071650422 746 6849351 SGTC_264 promethazine 12.5 mM 1.16940811243351 0.182284871106731 no 651 0.121119621455159 772 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2882 9058044 58.44 µM 1.16783257464016 0.1826359135562 no 652 0.121437152851648 611 18076804 SGTC_69 0096-0274 206.684 µM 1.16702393882726 0.182816247918019 no 653 0.121600351107551 726 6741392 SGTC_1431 4049-0260 9.09 µM 1.16645453088586 0.182943298591765 no 654 0.121715361026032 657 3854841 SGTC_3191 9110352 49.47 µM 1.16606915359307 0.183029318191149 no 655 0.121793243501244 628 17122424 SGTC_1108 betulinic acid 729.144 nM 1.1651985527406 0.183223736833822 no 656 0.12196931566751 649 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2694 st077685 81.9 µM 1.16332666020116 0.18364219538552 no 657 0.122348496439201 636 2838096 SGTC_1179 1021-1431 9.29 µM 1.15739968192678 0.184971085408182 no 658 0.123554551974926 692 2840958 SGTC_1227 3909-8010 46.6 µM 1.15596278339884 0.185294150629698 no 659 0.123848190066682 636 15982272 SGTC_2643 anethole 100 µM 1.15588106743506 0.185312533769396 no 660 0.123864903839446 688 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2903 5923464 63.88 µM 1.15485834617747 0.185542704870967 no 661 0.124074219647547 628 2876576 SGTC_1439 4092-1168 46 µM 1.15359143708 0.18582807818185 no 662 0.124333855315254 674 2886240 SGTC_767 0929-0023 86 µM 1.1515542441074 0.186287529623707 no 663 0.124752146411487 761 1204563 SGTC_3205 9113483 49.47 µM 1.14954150043256 0.186742157566184 no 664 0.125166382221419 696 17018033 SGTC_3275 9138069 49.47 µM 1.14385889342472 0.188029417310226 no 665 0.126341080496422 639 17617007 SGTC_2465 5809242 33.21 µM 1.14341010780251 0.188131311887049 no 666 0.126434178882755 659 2731748 SGTC_1659 st012954 42.1 µM 1.14232413515237 0.188378017623251 no 667 0.126659656336219 655 24207262 SGTC_1303 1160-0052 261 µM 1.14021272059042 0.188858248872427 no 668 0.127098844579395 673 3562476 SGTC_151 3013-0144 2.285 µM 1.13807945304816 0.189344215854778 no 669 0.127543653483214 694 906558 YHR107C CDC12 SGTC_2191 5911152 200 µM 1.13780177116701 0.189407529480762 no 670 0.127601632617694 658 2875902 SGTC_330 1488-0319 80.1 µM 1.13619985204461 0.189773033831525 no 671 0.127936466225816 678 6846614 SGTC_1167 k781-0610 148 µM 1.1346609644251 0.190124564690454 no 672 0.128258699423158 718 4525169 SGTC_1872 amphotericin b 148 nM 1.13368788983823 0.190347052230974 no 673 0.128462745614907 691 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1957 st077035 62.4 µM 1.13057786222086 0.191059212641377 no 674 0.129116404766823 683 705593 SGTC_247 mechlorethamine 29.705 µM 1.12992751851064 0.191208340151181 no 675 0.129253383667968 620 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_758 0868-0029 16 µM 1.12992203450785 0.191209597967523 no 676 0.129254539166334 679 762687 SGTC_2340 7987427 183.45 µM 1.12940892816895 0.191327306988132 no 677 0.129362684124451 668 2239331 SGTC_2359 9039622 200 µM 1.1283373896969 0.191573266157365 no 678 0.129588729305303 722 6463596 SGTC_1800 st050079 29.0735 µM 1.12811392073982 0.191624585250689 no 679 0.129635905405506 816 3645560 SGTC_681 1642-0006 26.6 µM 1.12801313174367 0.191647733949434 no 680 0.129657186668029 660 4446530 SGTC_848 0368-0089 85.6 µM 1.12715731411544 0.191844362752893 no 681 0.129837987230669 709 762535 SGTC_3183 9108214 49.47 µM 1.12669150533132 0.191951436767471 no 682 0.129936467613773 566 4974831 SGTC_641 4092-0595 30 µM 1.12628035734324 0.19204597645982 no 683 0.130023434672354 710 786260 SGTC_1669 st015249 58.4 µM 1.125878051292 0.192138510605865 no 684 0.130108570453044 683 722793 SGTC_665 3914-0008 307 µM 1.12415954860105 0.192534089305967 no 685 0.130472673349962 665 1069549 SGTC_188 3229-0966 278.469 µM 1.12136925295056 0.193177441362582 no 686 0.131065359166723 798 5722370 SGTC_2399 5884133 200 µM 1.11964277134895 0.193576168636715 no 687 0.131433010673564 660 722445 SGTC_839 0122-0028 230 µM 1.11782923769468 0.193995540494451 no 688 0.131819965861758 732 759448 SGTC_2133 5320837 200 µM 1.10990295638894 0.195834947487011 no 689 0.13352042320694 647 2841355 SGTC_113 0099-0221 2.5 µM 1.10830566044456 0.19620690016712 no 690 0.133864915855758 674 89219 SGTC_3260 9137109 49.47 µM 1.10448421815642 0.197098513115979 no 691 0.134691572903798 586 17478346 SGTC_662 k832-1615 104 µM 1.10435929656065 0.19712770095367 no 692 0.134718655032816 688 5878478 SGTC_3058 9093861 49.47 µM 1.10273754310026 0.197506859778607 no 693 0.1350705790032 691 17217477 SGTC_2162 5663267 200 µM 1.10245664564687 0.197572577138653 no 694 0.135131598349077 742 6456493 SGTC_1915 st067105 30.6 µM 1.09937287486327 0.19829490948673 no 695 0.135802728647577 695 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1712 st032288 53.4 µM 1.0982246611525 0.198564270002186 no 696 0.136053200069697 828 2883011 SGTC_2020 4017018 200 µM 1.0966191884356 0.198941269152365 no 697 0.136403947912279 700 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1828 st055811 49 µM 1.09599106021551 0.199088884346869 no 698 0.136541343370634 667 5877589 SGTC_1667 st014849 34.6 µM 1.09534415967548 0.199240980144474 no 699 0.13668294394994 742 5348460 SGTC_3322 9139058 2.11 µM 1.09527424435423 0.199257422450455 no 700 0.136698253780711 732 4908926 YPR165W RHO1 SGTC_2451 5856223 45.7 µM 1.09512968231957 0.19929142235713 no 701 0.136729913225504 691 2179896 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.09428944533949 0.199489108951491 no 702 0.13691402645191 792 688761 SGTC_2455 5377712 9.75 µM 1.09422632859977 0.199503963495096 no 703 0.136927863468025 636 2243908 SGTC_1937 st074714 47.2 µM 1.09351201035637 0.19967212490881 no 704 0.137084529314865 695 17250970 SGTC_1351 1496-0003 46.5 µM 1.09208223651386 0.200008971575944 no 705 0.137398478224814 746 3891978 SGTC_115 0527-0192 112.043 µM 1.09121502689979 0.200213447633001 no 706 0.137589138622368 800 4233931 SGTC_835 0312-0010 67.2 µM 1.09076427704341 0.200319777826698 no 707 0.137688309539924 673 1626196 SGTC_3130 9127414 49.47 µM 1.09023866438095 0.200443810713054 no 708 0.137804012856429 707 1494646 SGTC_692 k241-0027 77.8 µM 1.08867985582353 0.200811925989866 no 709 0.138147544012449 701 3600480 SGTC_1410 3909-8106 77.9 µM 1.0885063941649 0.200852914324932 no 710 0.138185807670063 707 1039210 SGTC_802 4112-3352 742 µM 1.08786840190938 0.201003712671081 no 711 0.138326603624114 763 704594 SGTC_1617 st002906 78 µM 1.08335054299618 0.202073513499001 no 712 0.139326429484429 740 5150859 SGTC_2620 irigenin 100 µM 1.08289641973225 0.202181235195271 no 713 0.139427200613634 742 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2990 9074105 71.4286 µM 1.08155144752199 0.202500474931307 no 714 0.139725944245994 683 6502001 SGTC_3325 9138760 55.175 µM 1.08094484685338 0.202644554926553 no 715 0.139860823962034 703 43844959 SGTC_2213 7173844 200 µM 1.07918731098569 0.203062351215366 no 716 0.140252117553935 746 892728 SGTC_2016 5121758 140 µM 1.07787977588452 0.203373508023297 no 717 0.140543705953657 775 2795203 SGTC_2902 5787006 60.46 µM 1.07755630675093 0.203450528507943 no 718 0.140615905017139 716 591003 SGTC_2192 5915882 198.485 µM 1.0758533297511 0.203856307282052 no 719 0.140996428552102 680 2876149 SGTC_2132 5317594 122.667 µM 1.07159515550777 0.204873037243772 no 720 0.141950955116727 669 794577 SGTC_1770 st043884 66.3 µM 1.07109899761975 0.204991701348969 no 721 0.142062459442663 734 670149 SGTC_3148 9097893 49.47 µM 1.06965854069776 0.205336441113133 no 722 0.142386517203417 678 17174100 SGTC_3038 9091290 49.47 µM 1.06731607846238 0.205897789585277 no 723 0.142914565012068 720 25236843 SGTC_3309 9129340 25.759 µM 1.06320424845914 0.20688534862838 no 724 0.14384466809184 793 17158987 SGTC_884 0851-0618 334 µM 1.06131427258335 0.207340212575266 no 725 0.144273550794626 761 9642473 SGTC_25 0118-0223 35.662 µM 1.05817821892911 0.208096275563465 no 726 0.144987099683942 748 5333628 SGTC_1421 4029-0249 71.4 µM 1.05762762280696 0.208229185069248 no 727 0.14511262202047 830 2894095 SGTC_629 3448-6466 76.7 µM 1.05661592682974 0.208473530925029 no 728 0.145343454357982 761 573744 SGTC_462 ag-879 158 µM 1.05510884481498 0.208837836300713 no 729 0.145687773652441 790 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_598 3937-0236 20.2 µM 1.05310480333078 0.209322851745327 no 730 0.146146480830329 804 1379313 SGTC_755 1995-0008 37.3 µM 1.0508517648419 0.209868919943256 no 731 0.146663338407881 778 689533 SGTC_706 4262-0057 46.9 µM 1.05052865616555 0.209947300280402 no 732 0.146737561493889 717 883298 SGTC_542 3381-0244 89.3 µM 1.05021549671211 0.210023283529617 no 733 0.146809523134982 827 1112843 SGTC_3273 9137859 49.47 µM 1.05011607270585 0.210047410590441 no 734 0.146832374959809 751 2377234 SGTC_2234 tolnaftate 200 µM 1.05003151594484 0.21006793112255 no 735 0.146851811542905 718 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1076 itraconazole 331 nM 1.04939497297393 0.210222447412118 no 736 0.146998185463505 779 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2206 7254556 146.969 µM 1.04899731204218 0.210319010647576 no 737 0.147089677771822 708 4398905 SGTC_317 4495-0002 170 µM 1.04789767394445 0.21058616918799 no 738 0.147342877040413 699 15991618 SGTC_2105 5350118 200 µM 1.04771452583198 0.210630684603203 no 739 0.147385076517882 755 2133313 SGTC_2529 gangaleoidin 93.61 µM 1.04518324895374 0.211246494219202 no 740 0.147969141942245 768 4565183 SGTC_1129 3453-1384 223 µM 1.0435534961524 0.211643538454092 no 741 0.148346008985457 795 1084452 SGTC_298 1391-0729 10 µM 1.04105423638211 0.212253261841617 no 742 0.148925188626077 744 3237558 SGTC_3335 9143315 29.6265 µM 1.04003794991957 0.212501490039234 no 743 0.149161134852303 742 4899691 SGTC_2516 gossypol 71.55 µM 1.03885992980676 0.212789433820552 no 744 0.149434942230507 795 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2939 9044578 71.43 µM 1.03881118295939 0.212801353931383 no 745 0.149446279691062 729 2653634 SGTC_174 3553-0389 74.3 µM 1.03865979163895 0.212838376273376 no 746 0.149481493692488 694 738071 SGTC_1865 st057639 52.2 µM 1.03770129562121 0.213072861144507 no 747 0.149704570793685 763 688818 SGTC_2553 4-methylesculetin 85.09 µM 1.0308888049024 0.214743794299953 no 748 0.151296483532817 774 5319502 SGTC_2152 5568786 200 µM 1.02880486532219 0.215256449200626 no 749 0.151785690006092 759 5399883 SGTC_2335 9018011 154.17 µM 1.02804091972241 0.215444559696125 no 750 0.151965289839341 807 6458208 SGTC_244 nsc-207895 1.295 µM 1.02757726748488 0.215558773803034 no 751 0.152074360996151 655 42640 SGTC_1000 4048-0884 8.67 µM 1.02720830936758 0.215649686449582 no 752 0.152161193118868 747 13040088 SGTC_2566 crystal violet carbinol 226 nM 1.02327361469159 0.216620591573413 no 753 0.153089247703433 640 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2189 6047310 154.431 µM 1.02011085980328 0.217402846629333 no 754 0.153837943457487 750 711535 SGTC_2732 terfenadine 20 µM 1.01922924547779 0.2176211896679 no 755 0.154047072742154 734 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1936 st074407 74.3 µM 1.0179035697916 0.217949748256214 no 756 0.154361892496441 818 809813 SGTC_1931 st074438 57.1 µM 1.01724362677546 0.218113416667067 no 757 0.154518773400654 753 2787313 SGTC_3195 9113082 49.47 µM 1.01506163984729 0.218655061880501 no 758 0.155038222882381 768 17018038 SGTC_482 fipronil 114 µM 1.01501506467753 0.218666631894588 no 759 0.155049323243043 756 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2521 angolensin 13.4 µM 1.01370787365114 0.218991502679493 no 760 0.155361082953756 747 821428 A flavenoid. SGTC_2423 st077119 87.2 µM 1.01258841031229 0.219269938809368 no 761 0.155628398979926 765 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2453 5731132 22.18 µM 1.01219340638754 0.219368233861753 no 762 0.155722794110814 833 1362040 SGTC_499 genistein 192 µM 1.01075809726434 0.219725617542221 no 763 0.156066111513786 779 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_322 k048-0136 19.3 µM 1.00946303433497 0.220048367415628 no 764 0.156376310616367 743 6823282 SGTC_1965 Pectolinarigenin 58.4 µM 1.00826331359365 0.220347599053737 no 765 0.156664035025452 792 5320438 An anti-inflammatory. SGTC_2236 dapsone 200 µM 1.00780574047433 0.220461787328449 no 766 0.156773864766569 840 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_579 4491-1009 110 µM 1.00734459683372 0.220576900937092 no 767 0.156884602781528 1000 1271041 SGTC_2401 5128683 200 µM 1.00407309514114 0.221394542122366 no 768 0.15767169130332 733 708373 SGTC_3126 9127922 49.47 µM 1.00222433627738 0.221857364814285 no 769 0.158117628266225 770 45595682 SGTC_2138 5575593 77.673 µM 1.00205213920389 0.221900501153292 no 770 0.158159205823789 778 762213 SGTC_1963 st076565 50.3 µM 0.998270993135321 0.222848906139184 no 771 0.159073984656496 788 4914280 SGTC_2144 5628481 200 µM 0.996306859277034 0.223342469517237 no 772 0.159550536018438 779 2818399 SGTC_2433 5607874 27.82 µM 0.996161259518426 0.223379081746497 no 773 0.159585899574289 783 2252428 SGTC_1668 st014914 51.6 µM 0.993337698987585 0.224089763674479 no 774 0.160272705781731 820 2839556 SGTC_342 k048-0088 23.3 µM 0.99125952693868 0.2246136529561 no 775 0.160779435194781 797 6820570 SGTC_58 0957-0393 9 µM 0.990210083391993 0.224878472429513 no 776 0.161035722496107 954 6997992 SGTC_3294 9122953 26.2835 µM 0.989674207624291 0.225013765032098 no 777 0.161166692864004 817 16459826 SGTC_1133 3473-0247 50 µM 0.989344884632618 0.225096932116147 no 778 0.16124721530394 773 711311 SGTC_2092 5303694 80.6725 µM 0.987646758054472 0.225526052598428 no 779 0.161662839043666 817 1963699 SGTC_1817 st052116 64.4 µM 0.98753649199801 0.225553933083496 no 780 0.161689851254002 808 4361398 SGTC_2188 6126565 140.678 µM 0.986680750606777 0.225770371364333 no 781 0.161899584815068 779 874518 SGTC_1244 0416-0015 52.5 µM 0.984640722850561 0.226286818684535 no 782 0.162400289567381 799 96201 SGTC_2417 cerulenin 830 nM 0.984605549362753 0.226295728947962 no 783 0.162408931383142 800 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1733 st037357 54.9 µM 0.984593774726086 0.226298711781865 no 784 0.162411824374395 791 1272339 YGL099W LSG1 SGTC_1573 oleylamine 1.06 µM 0.98399061004333 0.226451539414231 no 785 0.162560064906507 792 5356789 An amine of the fatty acid oleic acid. SGTC_3219 9131112 49.47 µM 0.983567539452257 0.226558770239775 no 786 0.162664096005133 782 17612988 YMR079W SEC14 SGTC_1479 0549-0158 134 µM 0.983151385317568 0.226664275990729 no 787 0.162766468621458 864 5440202 SGTC_325 2810-4341 181 µM 0.982660749470262 0.226788700377091 no 788 0.162887217317693 832 774970 SGTC_2876 9059903 25.97 µM 0.982513904392013 0.226825947521535 no 789 0.162923368175623 864 6916095 SGTC_2061 5245884 80.95 µM 0.98042802265909 0.227355402397871 no 790 0.163437441429383 828 573863 SGTC_570 0987-0065 62.6 µM 0.979630006555556 0.227558145107963 no 791 0.163634393776787 723 3104428 SGTC_655 k060-0012 42 µM 0.975586313446503 0.228587042890936 no 792 0.164634754831636 803 5994525 SGTC_3310 9130229 44.1445 µM 0.975052514066417 0.228723060468412 no 793 0.164767105841968 807 7761258 SGTC_197 4544-0043 41.561 µM 0.973947130334804 0.229004868052425 no 794 0.16504139540139 850 896523 SGTC_927 2425-1185 123 µM 0.9738798918457 0.229022016180016 no 795 0.165058089470969 811 730375 SGTC_534 k292-0788 63.4 µM 0.97334309986004 0.229158942431149 no 796 0.165191404164406 920 4146317 SGTC_1397 3532-0190 20.1 µM 0.972758420399245 0.229308136165362 no 797 0.165336691200064 757 5322280 SGTC_39 0986-0283 58.349 µM 0.971449475069463 0.229642339492515 no 798 0.165662250758597 908 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2403 6032726 181.2 µM 0.971279798846117 0.229685681634649 no 799 0.165704482786585 790 2881040 SGTC_2058 5236698 133 µM 0.970565779405413 0.229868121159652 no 800 0.165882276883923 800 766665 SGTC_447 ml7 120 µM 0.970257300833156 0.229946965788757 no 801 0.165959127583344 842 4216 Selective myosin light chain kinase inhibitor. SGTC_1559 coumarin 343 70.1 µM 0.969685189276265 0.230093232938627 no 802 0.166101717580559 787 108770 A hepatotoxic, DNA x-linker. SGTC_3211 9128781 49.47 µM 0.969653971387638 0.230101215662037 no 803 0.166109500435293 774 17194361 SGTC_198 3454-2873 16.191 µM 0.96830089855531 0.230447358659516 no 804 0.166447058076457 815 710957 SGTC_439 amiodarone 34.4 µM 0.966934286772169 0.230797260455315 no 805 0.166788442561273 838 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_345 1362-0200 395 µM 0.964631719999831 0.231387470987519 no 806 0.16736465292842 800 1419823 SGTC_1612 st002233 45.4 µM 0.963561657883034 0.23166204324163 no 807 0.167632868822053 823 1035021 SGTC_2678 equilin 100 µM 0.958218166615841 0.233035868406794 no 808 0.168976379233474 866 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2923 7992654 58.14 µM 0.95781588168575 0.23313947968952 no 809 0.169077804656087 820 2985126 SGTC_829 1635-0120 117 µM 0.95724064813758 0.233287679512736 no 810 0.169222902370166 889 285054 SGTC_2489 cantharidin 73.42 µM 0.955252089942808 0.233800402605755 no 811 0.169725114712737 827 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2084 5306078 60.6385 µM 0.954116074150648 0.234093589129041 no 812 0.170012445210826 829 679340 SGTC_543 3844-1095 191 µM 0.953723789892008 0.234194878356207 no 813 0.170111737366774 880 4230703 SGTC_3258 9138477 49.47 µM 0.953304037315711 0.234303286870558 no 814 0.170218023253484 850 4970355 SGTC_2543 pimpinellin 60.67 µM 0.950143370416491 0.235120476258853 no 815 0.171019704236301 815 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1678 st019265 80.2 µM 0.950105597858161 0.235130251850985 no 816 0.171029299561947 889 5367020 SGTC_2819 7996655 46.38 µM 0.950105207763854 0.235130352809121 no 817 0.171029398659015 745 6456960 SGTC_3288 9119690 36.221 µM 0.949939984981227 0.235173115350117 no 818 0.171071374102183 770 17595618 YKL019W RAM2 SGTC_1873 rapamycin 2 nM 0.949882917043 0.235187886526816 no 819 0.171085873948364 877 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2887 9044784 58.44 µM 0.949814883558511 0.235205496639534 no 820 0.171103160952324 960 6465546 SGTC_2376 9072922 81.32 µM 0.947756990012103 0.235738515627962 no 821 0.171626590405134 868 17087968 SGTC_1030 k029-0042 36.7 µM 0.946748926526542 0.235999858960312 no 822 0.171883366327542 881 6080581 SGTC_2950 9072895 21.46 µM 0.946292077345464 0.236118350965844 no 823 0.171999816590273 856 17332245 SGTC_856 0433-0016 11.3 µM 0.945907837884261 0.236218035711063 no 824 0.172097797715105 865 3911780 SGTC_1447 4239-0816 81.9 µM 0.942634427015802 0.237068208617372 no 825 0.172933962104622 804 1341554 SGTC_2310 7668677 200 µM 0.942479599817634 0.23710846206515 no 826 0.172973575378039 835 2197143 SGTC_560 2332-1943 155 µM 0.939936557596709 0.237770163512419 no 827 0.173625051979089 858 21177716 SGTC_3115 9123671 49.47 µM 0.939562599281709 0.237867553092185 no 828 0.173720984128538 928 3286988 SGTC_2247 cerulenin 830 nM 0.939022264383895 0.238008310583643 no 829 0.173859656686719 855 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3356 9151811 4.48 µM 0.937404399323378 0.238430038072251 no 830 0.174275289421362 852 1859254 YPR165W RHO1 SGTC_2775 cyproheptadine 69.59 µM 0.937037355344381 0.2385257720208 no 831 0.174369671541916 871 2913 A selective serotonin reuptake inhibitor. SGTC_3231 9132313 49.47 µM 0.936911691722061 0.238558552967921 no 832 0.174401992294241 869 4905967 SGTC_3221 9128209 49.47 µM 0.936777363275964 0.238593596970742 no 833 0.174436545852153 822 16460723 SGTC_312 4092-0653 6.84 µM 0.934993494582058 0.239059244967782 no 834 0.174895826010512 940 1148278 SGTC_389 tpck 16.7 µM 0.933455752898587 0.239461044133236 no 835 0.175292352881916 866 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2095 5432005 200 µM 0.93329616059287 0.239502765392561 no 836 0.175333538478691 829 783734 SGTC_1357 1503-1303 39.5 µM 0.932191709426036 0.239791604182668 no 837 0.175618729625213 897 292895 SGTC_2961 9083290 32.55 µM 0.931681970398289 0.239924976458728 no 838 0.175750453412945 829 17741490 SGTC_431 k089-0097 107 µM 0.930709935865574 0.240179419596765 no 839 0.176001814334635 907 5499420 SGTC_901 1112-0062 60.1 µM 0.93011989705322 0.240333941908982 no 840 0.17615450496107 854 1908457 SGTC_2655 perillic acid 100 µM 0.929163188456383 0.240584604597385 no 841 0.176402260767896 837 5702197 An apoptosis inducer. SGTC_503 tyrphostin 8 294 µM 0.927556858613356 0.241005791394035 no 842 0.176818742475124 873 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2585 alliin 100 µM 0.925569868627709 0.241527343269371 no 843 0.177334779136803 884 87310 A garlic compound which reacts with lipids. SGTC_2450 5739737 12.93 µM 0.92457318777809 0.241789186094948 no 844 0.177593982620008 821 2262825 SGTC_1024 4507-0395 26 µM 0.924277021110649 0.241867023145183 no 845 0.177671051760001 840 4201836 SGTC_2317 5986382 200 µM 0.9241431397901 0.241902213629273 no 846 0.177705897575919 919 877883 SGTC_1972 st070201 17.4 µM 0.924020122521408 0.241934550963855 no 847 0.177737919563462 895 2829099 SGTC_613 3914-0030 117 µM 0.923649635485051 0.242031954408409 no 848 0.17783438111301 667 1145395 SGTC_2145 5634607 200 µM 0.922957570612692 0.242213959705483 no 849 0.178014658443395 834 308662 SGTC_1037 k284-1091 78.7 µM 0.922159024663976 0.242424060487358 no 850 0.178222816372545 823 3334711 SGTC_771 0250-0039 27.3 µM 0.922112921174338 0.242436193522412 no 851 0.178234838906697 854 3005115 SGTC_966 1300-0360 30.2 µM 0.921671038291109 0.242552500331005 no 852 0.178350095850654 846 70588 SGTC_2369 9071472 200 µM 0.920336060431441 0.242904059746622 no 853 0.178698585201541 900 17296037 SGTC_31 0508-1974 57.237 µM 0.91747078128692 0.243659545952478 no 854 0.17944799856782 871 6810525 SGTC_91 0417-1751 58.384 µM 0.917140211354708 0.243746788660453 no 855 0.179534586028686 1015 6795624 SGTC_1578 josamycin 24.2 µM 0.916927432982645 0.243802953205144 no 856 0.17959033377966 804 5282165 A P450 substrate. SGTC_1094 duloxetine 25.4 µM 0.916390172740659 0.243944798401732 no 857 0.179731143909146 876 60834 A selective serotonin reuptake inhibitor. SGTC_3031 9088762 49.47 µM 0.916004353600002 0.244046688215632 no 858 0.179832305734455 948 205253 SGTC_2412 st077135 33.4 µM 0.914399715487578 0.244470698412502 no 859 0.180253425639144 872 13258915 SGTC_3001 9076041 71.4286 µM 0.914071583869286 0.244557452891816 no 860 0.180339616388656 877 16004211 SGTC_2659 sanguinarine 24.21 µM 0.910297556544906 0.245556456351634 no 861 0.181332803412097 855 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_178 4092-0806 87.505 µM 0.909212372218472 0.245844115197747 no 862 0.181619017345015 927 2169044 SGTC_1632 st005650 90 µM 0.908137286675624 0.246129275337411 no 863 0.181902846360217 859 2759605 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.907798842135146 0.246219082468391 no 864 0.181992255123693 972 91467 include heat shock SGTC_1048 3161-0300 24.5 µM 0.907559380021258 0.246282634969809 no 865 0.182055531749348 937 2165101 SGTC_1511 0906-3109 28.5 µM 0.907224558767754 0.246371510233323 no 866 0.182144029593399 986 2882180 SGTC_1199 1638-0010 4.46 µM 0.906977218382331 0.246437175532343 no 867 0.182209422312393 879 3111136 SGTC_1253 0550-0034 176 µM 0.90418740953168 0.247178478529408 no 868 0.182948017587223 835 5969915 SGTC_86 0417-1630 471.922 µM 0.902710102457632 0.247571508321673 no 869 0.183339886660611 1000 3634867 SGTC_3280 9140961 49.47 µM 0.902431341235027 0.247645708705848 no 870 0.183413889250764 868 4901226 SGTC_2431 5490079 200 µM 0.897181141224488 0.249045417486724 no 871 0.184811133335173 931 5722345 SGTC_2551 apiole 73.87 µM 0.896430470230665 0.24924589052613 no 872 0.185011449832145 796 10659 A possible DNA adduct former. SGTC_1776 st049249 45.9 µM 0.894782109279502 0.249686400179444 no 873 0.185451787932405 939 1822314 SGTC_191 3914-0123 66.505 µM 0.894665849738047 0.24971748509969 no 874 0.185482869690326 779 3144412 SGTC_256 clotrimazole 625 nM 0.894374931573739 0.249795278411918 no 875 0.185560660251857 897 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_624 k048-0052 28 µM 0.893603826823089 0.250001538816307 no 876 0.185766949063352 876 6835531 SGTC_231 b-estradiol 524 µM 0.893337416583023 0.250072821059897 no 877 0.185838253173165 849 450 A steroid. SGTC_1380 2291-0730 164 µM 0.893173249722428 0.250116751850478 no 878 0.185882200520887 847 2999191 SGTC_1426 4048-4480 71.7 µM 0.891478701411313 0.250570449393826 no 879 0.186336206387614 934 14224343 SGTC_1356 1502-0781 85.8 µM 0.889782078088063 0.251025138934121 no 880 0.186791455819529 894 567702 SGTC_2591 skatole 100 µM 0.889413054981981 0.251124093700302 no 881 0.186890565667514 904 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1266 0828-0227 32.9 µM 0.889275307110317 0.251161036535538 no 882 0.186927569442261 894 3913820 SGTC_2743 auranofin 4.32 µM 0.885146699292656 0.252269627731812 no 883 0.188038757642547 908 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1484 3473-2379 286 µM 0.884624941783244 0.252409910605492 no 884 0.188179474947054 1113 671917 SGTC_879 0831-1030 162 µM 0.883630133846464 0.252677494559558 no 885 0.188447953328961 930 1549252 SGTC_909 3448-9333 149 µM 0.882833584657117 0.252891858427683 no 886 0.188663095933826 862 3344074 SGTC_1909 st060837 51.5 µM 0.88240418638218 0.253007455927519 no 887 0.188779136319702 877 678937 SGTC_2703 st077852 53.4 µM 0.882339774891248 0.25302479842127 no 888 0.188796546643612 890 6281836 SGTC_2177 5811945 192 µM 0.879433924472383 0.253807835233539 no 889 0.189583022430876 945 5343475 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.879092950442001 0.25389980051298 no 890 0.189675439869138 844 61125 An anti-inflammatory. SGTC_2715 st079500 56.4 µM 0.8755432097957 0.254858251085903 no 891 0.190639205035373 882 28246688 SGTC_614 0462-0418 107 µM 0.874464031326658 0.255150010460791 no 892 0.19093279999857 855 5188303 SGTC_1677 st019204 53.9 µM 0.87329176908036 0.255467133146228 no 893 0.191252032877927 876 3945625 SGTC_316 k060-0003 58.6 µM 0.872593418927917 0.255656150040521 no 894 0.191442364456928 922 6152314 SGTC_524 r073-0010 27.8 µM 0.871629155939842 0.255917259441829 no 895 0.191705359839509 902 2772106 SGTC_965 1291-5240 308 µM 0.870184265146086 0.256308776697975 no 896 0.192099856714569 941 2834598 SGTC_876 0720-0963 56.8 µM 0.869683256156737 0.25644460629822 no 897 0.192236762519489 972 765861 SGTC_1741 st038134 10.228 µM 0.868613036588537 0.256734881352513 no 898 0.192529410751755 1001 1272587 SGTC_2956 9076196 2.52 µM 0.865212392235583 0.2576583702363 no 899 0.193461112478789 965 16423868 SGTC_440 fluspirilene 35.1 µM 0.864308661587004 0.257904079723845 no 900 0.193709176641831 950 3396 An atypical antipsychotic. SGTC_1011 4112-3381 17.4 µM 0.864185163918336 0.257937666146397 no 901 0.193743090454414 924 2877139 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.863705140620127 0.258068234817138 no 902 0.193874944486338 888 1241132 A phosphatase inhibitor. SGTC_1885 st057546 99.9 µM 0.863570770276973 0.258104790343022 no 903 0.193911863472551 993 702008 SGTC_222 nsc-310342 10.666 µM 0.862342109816777 0.258439172580109 no 904 0.19424964331859 920 432556 SGTC_1722 st034304 3.6505 µM 0.861457169090546 0.258680149801074 no 905 0.194493150547821 943 4036148 YLR033W RSC58 SGTC_2357 9067248 200 µM 0.857953822126867 0.25963528278157 no 906 0.195458981315043 929 9150235 SGTC_3286 9117135 37.221 µM 0.856211323431368 0.260111024963067 no 907 0.195940450176336 927 3438150 SGTC_1359 1582-0056 520 nM 0.854746412314796 0.260511326779902 no 908 0.196345775188504 1008 3661189 SGTC_419 nsc-638432 893 µM 0.853620262780156 0.26081927407726 no 909 0.196657713817634 964 368090 SGTC_286 k060-0067 22.9 µM 0.853035189283304 0.260979337199458 no 910 0.196819895115789 937 5985051 SGTC_956 1185-0240 191 µM 0.851363025362546 0.261437082443362 no 911 0.197283862196614 943 1416193 SGTC_320 4092-0846 5.34 µM 0.851053293921308 0.261521914874383 no 912 0.197369874418713 992 1359356 SGTC_2888 9058547 12.99 µM 0.850714745529645 0.26161465615046 no 913 0.197463915027676 874 16476514 SGTC_1774 st048371 48.465 µM 0.850682665150457 0.261623445061453 no 914 0.197472827591315 1007 4242727 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.850500519430523 0.26167334954248 no 915 0.197523435884696 901 6857784 SGTC_766 1391-0721 126 µM 0.849957175060936 0.261822244633405 no 916 0.197674448025173 988 1020919 YIL115C NUP159 SGTC_2821 7996764 71.43 µM 0.849943471184283 0.261826000529856 no 917 0.197678257656619 1024 2987135 SGTC_573 3702-0553 84.7 µM 0.849107262178718 0.262055237188391 no 918 0.197910804893289 947 1222756 SGTC_911 3456-4043 236 µM 0.84881345139128 0.262135806304343 no 919 0.197992552015112 1001 914281 SGTC_2727 riluzole 51.77 µM 0.848487103373369 0.262225312693303 no 920 0.198083375888195 949 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1275 0867-0008 21.1 µM 0.845983828225023 0.262912397955764 no 921 0.198780882950405 971 3422836 SGTC_3095 9117207 49.47 µM 0.844418090638199 0.263342620462594 no 922 0.199217908386748 945 17015229 SGTC_2534 helenine 20.12 µM 0.843544901711128 0.263582705297288 no 923 0.19946188222968 943 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_929 2805-0021 398 µM 0.843468906986117 0.263603605462635 no 924 0.199483124082986 953 3098024 SGTC_1174 0739-0097 51.1 µM 0.843293774799457 0.263651773757403 no 925 0.199532081773414 975 728447 SGTC_1202 1988-0068 29.6 µM 0.843260084698957 0.263661040385691 no 926 0.199541500571768 945 2850480 SGTC_2797 7859098 81.82 µM 0.842639376246709 0.263831799031065 no 927 0.199715080960673 967 972681 SGTC_2835 9006588 71.43 µM 0.841221078627247 0.264222188214946 no 928 0.200112047010535 903 2345538 SGTC_1087 pterostilbene 9.05 µM 0.837164625965823 0.265340356319522 no 929 0.201250019095305 1006 5281727 Similar to reservatol, lowers cholesterol. SGTC_709 3807-1509 243 µM 0.837091567098479 0.265360517117704 no 930 0.201270550081361 994 1886677 YPL242C IQG1 SGTC_2759 disulfiram 3.38 µM 0.836548700665028 0.26551034697145 no 931 0.201423145608232 964 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1147 3809-1045 12.3 µM 0.836378736531081 0.265557265491411 no 932 0.20147093545127 971 325925 SGTC_1486 3970-0793 4.53 µM 0.834328172525822 0.266123653970257 no 933 0.202048040249269 1023 2844330 SGTC_1038 k292-0204 154 µM 0.833556211987337 0.26633703639386 no 934 0.202265554659439 929 4454212 SGTC_607 4491-0986 66.8 µM 0.833157182567392 0.266447368536636 no 935 0.202378043601125 1018 698981 YDR232W HEM1 SGTC_2268 7933382 153.85 µM 0.831354773498845 0.266946024865148 no 936 0.202886620199043 1100 935025 YOR257W CDC31 SGTC_371 0195-0006 7.36 µM 0.830197163073494 0.267266538957731 no 937 0.203213659475782 891 3928593 SGTC_1247 0448-0043 5.84 µM 0.83004703750644 0.267308119286308 no 938 0.203256094844119 1009 3089013 YGL099W LSG1 SGTC_2407 paclitaxel 400 µM 0.829161956017785 0.267553326929593 no 939 0.203506384623579 1003 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1702 st027038 51 µM 0.828109025282018 0.267845184046634 no 940 0.203804379351887 1009 5521182 SGTC_2002 4023503 131 µM 0.82764849700029 0.26797288619422 no 941 0.203934797278167 1095 4736863 YCR052W RSC6 SGTC_469 w7 172 µM 0.826134941316313 0.268392803319435 no 942 0.204363774318438 1017 45115570 A P450 inhibitor. SGTC_904 1141-0088 396 µM 0.825009935151795 0.268705136478936 no 943 0.204682975101512 986 1378119 SGTC_2932 9016711 44.54 µM 0.823892038940417 0.269015676494392 no 944 0.205000452157245 1037 7117328 SGTC_1272 0839-0021 27 µM 0.823665866488369 0.269078526766749 no 945 0.205064719611928 1006 5027250 SGTC_2287 7945887 168.79 µM 0.823582121302244 0.269101800293103 no 946 0.205088519048691 1038 1245853 SGTC_1941 st076221 61.8 µM 0.822269693459491 0.269466667481656 no 947 0.20546171063915 1029 2828568 SGTC_2885 9057732 51.95 µM 0.819976378686238 0.270104825036798 no 948 0.206114786584277 1036 6471414 SGTC_515 4092-1064 102 µM 0.818122356975464 0.270621293200889 no 949 0.206643662025058 1069 717353 SGTC_1189 1431-2119 7.28 µM 0.817800074597826 0.270711120539214 no 950 0.206735677732959 1041 3107275 SGTC_125 0133-0007 11.75 µM 0.817681485822993 0.270744177641292 no 951 0.206769542437554 1125 26541 SGTC_1529 apigenin 74 µM 0.817276240689063 0.270857156574845 no 952 0.206885290710414 1028 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2892 9047358 58.44 µM 0.817231930224308 0.270869511386482 no 953 0.206897949226797 955 6466771 SGTC_654 1124-0271 80.9 µM 0.817058246926605 0.270917941133086 no 954 0.206947571110053 1009 5403748 SGTC_1565 sinapyl alcohol 95.1 µM 0.816618405351374 0.271040605617052 no 955 0.207073266777095 1017 5280507 A phenol propionate derived from cinnamic acid. SGTC_2459 5811157 9.22 µM 0.816582661423984 0.271050575219617 no 956 0.20708348347716 1042 2870684 YBR192W RIM2 SGTC_2187 6125751 200 µM 0.816171003278645 0.271165407012892 no 957 0.207201169371021 999 874498 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.81531772121757 0.271403506756433 no 958 0.207445233786106 978 2346 DNA damaging agent; causes G2/M arrest. SGTC_886 0866-0150 153 µM 0.815195665143744 0.271437573785273 no 959 0.207480159393255 1075 271463 SGTC_3171 9103192 49.47 µM 0.811899374952511 0.272358405054323 no 960 0.208424686570395 1092 13018434 SGTC_531 3788-1495 174 µM 0.811523560035506 0.272463488852828 no 961 0.208532534318393 957 2896655 SGTC_806 3966-4455 5.86 µM 0.809640850439954 0.27299022714602 no 962 0.209073311296003 917 714982 SGTC_2718 lomofungin 53.02 µM 0.808457010418057 0.273321696346622 no 963 0.20941377211515 1008 5351222 A RNA synthesis inhibitor. SGTC_685 1278-0033 54.9 µM 0.807888085740342 0.273481063255203 no 964 0.209577505282946 1033 3590572 SGTC_2007 4011539 71.82 µM 0.807525039272286 0.273582783694484 no 965 0.209682027260057 1006 45595301 SGTC_504 lovastatin 124 µM 0.802918511276426 0.274875090700623 no 966 0.211010917953642 1019 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3121 9125696 49.47 µM 0.802574808510983 0.274971632927951 no 967 0.211110266823639 1074 1235365 SGTC_2334 9017922 200 µM 0.800785326010563 0.275474548119948 no 968 0.211627967745776 1047 3163164 SGTC_2662 daunorubicin 22.37 µM 0.798617333978272 0.276084444941327 no 969 0.21225616673306 1014 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2142 5622915 118.518 µM 0.797784444682679 0.276318928459832 no 970 0.212497794855793 1032 5322196 SGTC_698 k064-0052 127 µM 0.795876509334479 0.276856437913858 no 971 0.213051908042339 1066 5088751 SGTC_1398 3558-0053 112 µM 0.794947315325418 0.277118398621599 no 972 0.213322074681825 994 4532369 SGTC_1708 st033234 31.827 µM 0.793545705270701 0.277513773367265 no 973 0.213729975711607 1099 674664 SGTC_1120 ficusin 1.78878 µM 0.793185479238142 0.277615432645254 no 974 0.213834883177663 1046 6199 A DNA cross-linker. SGTC_1779 st039427 55 µM 0.788810059913578 0.27885166889437 no 975 0.215111514454057 1124 1124498 SGTC_1312 1218-2183 165 µM 0.786700232817782 0.279448737779871 no 976 0.21572868388404 1091 6744073 SGTC_2468 5987765 72.9 µM 0.786032868281941 0.279637727266606 no 977 0.21592411573123 1095 26772094 SGTC_488 nitrendipine 139 µM 0.784168297036544 0.280166079628778 no 978 0.216470682436489 1080 4507 Dihydropyridine L-type calcium channel blocker. SGTC_942 3253-1115 227 µM 0.783201779914396 0.28044014600493 no 979 0.216754314925146 1070 46497897 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.782737563032686 0.280571825842092 no 980 0.216890619591033 1183 688664 SGTC_1339 1486-1321 22.7 µM 0.7820180138945 0.280775992379928 no 981 0.217101993527433 1040 3469382 SGTC_1643 st009866 20.2 µM 0.78119616825443 0.281009272618708 no 982 0.21734356351267 1081 3156273 YOR207C RET1 SGTC_182 3448-4371 550.524 µM 0.78093241649584 0.28108415819405 no 983 0.217421122525593 1103 3491403 SGTC_72 0744-0168 198.391 µM 0.779963543438228 0.28135932767459 no 984 0.217706167087781 1015 677577 SGTC_2720 fluspirilene 36.88 µM 0.778025903078359 0.281910026294818 no 985 0.218276871391288 1021 3396 An atypical antipsychotic. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.777888570273736 0.281949077481338 no 986 0.218317353493116 997 5711223 A potent inhibitor of glutathione S-transferases. SGTC_899 1083-0020 478 µM 0.776264942052272 0.282410960710509 no 987 0.218796284162994 1062 767123 SGTC_1257 0669-0121 16 µM 0.77490306740276 0.28279866177861 no 988 0.21919846973747 1153 4307855 SGTC_2649 anisomycin 9.56 µM 0.774043451050789 0.283043510549206 no 989 0.21945254822548 1046 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1057 3448-5381 134 µM 0.772866652012386 0.283378868934191 no 990 0.219800651233976 1098 5497911 SGTC_2754 granisetron 64.02 µM 0.771276039694986 0.283832456325103 no 991 0.22027166563503 1060 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_333 3486-0131 40.1 µM 0.770671765150653 0.284004865494296 no 992 0.220450755858355 1113 6744690 SGTC_9 0092-0002 10.449 µM 0.769555394538284 0.284323515572469 no 993 0.220781836561061 1069 759368 SGTC_2528 xanthyletin 44.79 µM 0.769437519125102 0.284357171188885 no 994 0.220816811343995 1074 65188 An natural product with antifungal activity of unknown mechanism. SGTC_714 4296-0578 26.1 µM 0.767394120228356 0.28494090181744 no 995 0.221423611670667 1098 1589775 SGTC_1408 3909-7976 48.8 µM 0.763676018132367 0.286004502754334 no 996 0.222530167799983 1141 24152374 SGTC_124 0136-0217 7.121 µM 0.763583716553528 0.286030930544016 no 997 0.222557678015977 1230 3976905 SGTC_2270 7924575 90.91 µM 0.763096697876815 0.286170392952182 no 998 0.222702864614228 1075 1262135 SGTC_2432 5630864 12.22 µM 0.762450823551494 0.286355394983281 no 999 0.222895491386941 1059 5714970 SGTC_305 1682-2595 20.8 µM 0.761706764152263 0.286568591159375 no 1000 0.223117518672541 1099 226033 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.759915707955719 0.287082093029906 no 1001 0.223652485810591 1101 2333 A French combination drug. SGTC_782 0083-0095 30.5 µM 0.759596144374402 0.287173758775269 no 1002 0.223748012262064 1135 3591729 An indicator and reagent. SGTC_639 0833-0042 114 µM 0.755717732222352 0.288287371312155 no 1003 0.224909225104186 1096 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_509 pifithrin 175 µM 0.754467757272207 0.288646711376194 no 1004 0.225284199483737 1149 4817 A p53 inhibitor. SGTC_2304 7443016 91.4 µM 0.752862023636618 0.289108633505818 no 1005 0.225766415442912 1032 939854 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.746170769875033 0.291037242252405 no 1006 0.227782131508195 1110 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2770 toltrazuril 17.5 µM 0.743354324489755 0.291850814922018 no 1007 0.228633594946268 1122 68591 Kills coccidiodes. SGTC_3203 9113543 49.47 µM 0.743015644362639 0.291948719093053 no 1008 0.228736104457647 1099 17018012 SGTC_2227 7312221 64.1025 µM 0.742505614403966 0.292096185175586 no 1009 0.228890525706796 1148 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1367 1812-0510 76.9 µM 0.74108972620902 0.292505745641881 no 1010 0.229319519242342 1110 1142582 YDR527W RBA50 SGTC_991 3996-0057 64.7 µM 0.740156361676505 0.292775876970128 no 1011 0.229602561452332 1077 715343 SGTC_24 0417-1663 219 µM 0.739028603541763 0.293102423510038 no 1012 0.229944814343661 1114 4329390 SGTC_606 k015-0008 38.6 µM 0.737962286186661 0.293411334921761 no 1013 0.230268683615084 1182 1970475 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.736679451697511 0.293783170956643 no 1014 0.230658652813236 1292 16725076 SGTC_3022 9087993 49.47 µM 0.736290253277664 0.293896025170564 no 1015 0.230777038258365 1136 17173644 SGTC_347 4534-1311 26.2 µM 0.735804141907013 0.294037008975611 no 1016 0.230924950107018 1154 2862016 SGTC_3254 9136651 49.47 µM 0.73342806308257 0.294726577537927 no 1017 0.231648694154777 1144 16454030 SGTC_2136 5328288 199.296 µM 0.732971901432555 0.294859046781618 no 1018 0.231787783653013 1069 262395 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.732310308420923 0.29505122199806 no 1019 0.231989594436876 1177 66535 A nucleotide analog. SGTC_867 0518-0118 155 µM 0.731247653287258 0.295360015812517 no 1020 0.232313948953535 1185 6848158 SGTC_1171 0368-0077 21.4 µM 0.730426002455592 0.295598878785912 no 1021 0.232564914520175 1106 3239779 SGTC_2441 5730946 39.09 µM 0.729120580742531 0.295978561813234 no 1022 0.232963953188131 1147 1774275 SGTC_52 0329-0193 875 nM 0.727597421866281 0.296421856686869 no 1023 0.233430029634854 1185 3739292 SGTC_1187 1391-0724 117 µM 0.726682303031664 0.296688335957134 no 1024 0.233710298448488 1163 6997986 SGTC_1092 toremifene 6.32 µM 0.72609654604783 0.296858963818481 no 1025 0.23388979314511 1175 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1125 tnp00248 1.32998 µM 0.724601047091211 0.29729479818861 no 1026 0.234348408184804 1243 24207736 SGTC_1192 1488-0095 21.4 µM 0.723910580719356 0.297496119924228 no 1027 0.234560316877248 1122 915875 SGTC_1260 0700-1617 7.75 µM 0.72384587496007 0.297514989602278 no 1028 0.234580180932607 1144 2853078 SGTC_870 0573-2213 57.6 µM 0.720946927007246 0.298360949120641 no 1029 0.2354710845023 1162 3916321 SGTC_628 1636-0253 16 µM 0.72068908328172 0.298436245050385 no 1030 0.235550415254849 1150 4456143 SGTC_2071 5230951 39.92 µM 0.720644391565405 0.298449296874807 no 1031 0.235564167049844 1212 1799272 SGTC_577 r071-0003 38.6 µM 0.718974897805862 0.298937043865232 no 1032 0.236078193215445 1214 4568517 YMR134W ERG29 SGTC_258 haloperidol 50.781 µM 0.716851575127124 0.299557900691973 no 1033 0.236732842147426 1154 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1838 st055369 84.5 µM 0.716377162866036 0.299696698058414 no 1034 0.236879246170055 1160 676036 SGTC_793 0488-0545 106 µM 0.714689678085403 0.300190636321973 no 1035 0.237400408608292 1158 292548 SGTC_2352 9027995 87.8 µM 0.712667926949448 0.300782900795359 no 1036 0.238025633855594 1120 2997347 SGTC_2622 2-methoxyxanthone 59.94 µM 0.710970322808379 0.301280614411464 no 1037 0.238551313182157 1198 71034 A hepatoprotective. SGTC_750 4073-0104 132 µM 0.710126149629093 0.301528252090491 no 1038 0.238812955851756 1034 22330957 SGTC_2098 5376439 882.5 nM 0.708363279552978 0.302045684010194 no 1039 0.239359844850652 1215 2844116 SGTC_2461 5755302 26.15 µM 0.707313541013071 0.302353989159291 no 1040 0.239685826222734 1169 2788904 SGTC_783 0848-0141 92.7 µM 0.707179837517393 0.302393267618806 no 1041 0.239727363329062 1172 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3145 9085516 49.47 µM 0.707129982199529 0.302407914344307 no 1042 0.239742852677676 1182 25236195 SGTC_2488 5268135 45.7 µM 0.706137071270867 0.302699682540764 no 1043 0.24005144989922 1171 1270356 YLR208W SEC13 SGTC_1036 k216-0215 33.5 µM 0.704947848765691 0.303049303027323 no 1044 0.240421345709201 1186 622330 SGTC_993 3909-8757 62.7 µM 0.70412193009925 0.303292221779837 no 1045 0.24067842204035 1126 4288324 YLR208W SEC13 SGTC_2814 7977482 42.97 µM 0.700747864519826 0.304285502887406 no 1046 0.241730189721642 1222 6456762 SGTC_612 0302-0167 22.4 µM 0.699712099362979 0.304590709065896 no 1047 0.242053559387371 1221 235821 SGTC_150 3970-0969 77.2 µM 0.699522578919716 0.304646569288239 no 1048 0.242112753740685 1198 6615640 SGTC_3008 9078912 71.4286 µM 0.698199331330352 0.305036716919576 no 1049 0.242526272301748 1183 16648731 SGTC_1716 st033144 30.6155 µM 0.697630786109453 0.30520441547569 no 1050 0.242704061683223 1206 674617 SGTC_403 arphamenine a 50 µM 0.697320841462412 0.305295854227482 no 1051 0.242801013966543 1159 5487158 An arginine aminopeptidase inhibitor. SGTC_295 k015-0027 31 µM 0.696639854925661 0.305496799091776 no 1052 0.243014103663621 1171 3887424 SGTC_1454 4239-0054 42.6 µM 0.695170145123487 0.305930679355216 no 1053 0.243474339839085 1266 1340767 SGTC_1818 st052136 56.3 µM 0.693447808842447 0.306439485483141 no 1054 0.244014284079695 1115 674169 SGTC_760 0568-0725 82.9 µM 0.692745981801047 0.306646923733049 no 1055 0.244234488609825 1205 3916171 SGTC_1935 st074532 41.6 µM 0.689812327143052 0.307514690947942 no 1056 0.245156107782264 1266 2829742 SGTC_572 0960-0087 17.7 µM 0.688509903978872 0.307900290187793 no 1057 0.245565867809508 1205 6796365 SGTC_955 1216-0110 33 µM 0.687931758955444 0.308071525544088 no 1058 0.24574787792148 1181 3619719 SGTC_2811 7967822 32.47 µM 0.686225242099883 0.308577206391038 no 1059 0.246285541268551 1213 2232244 SGTC_563 tetrahydrosecaminediol 614 µM 0.685778197028439 0.308709736385291 no 1060 0.24642649359223 1250 334274 A psychoactive constituent of the cannabis plant. SGTC_3049 9092223 49.47 µM 0.685212243086053 0.308877553581285 no 1061 0.246604999609773 1172 8623917 SGTC_2880 9042983 58.44 µM 0.684555268286738 0.309072410418755 no 1062 0.246812301106266 1217 6464714 SGTC_611 3453-1652 23.7 µM 0.680014575221034 0.310420633612535 no 1063 0.24824761606483 1223 1560575 SGTC_3270 9137563 49.47 µM 0.679640587859198 0.310531791943365 no 1064 0.248366031691803 1186 17015724 SGTC_2917 7979103 53.79 µM 0.678699992349592 0.310811436753359 no 1065 0.248663985509698 1227 2980565 SGTC_1159 4092-0538 61.2 µM 0.678645276156698 0.310827707578804 no 1066 0.248681323895761 1260 717301 SGTC_1986 st071812 45 µM 0.678236868265434 0.310949166554945 no 1067 0.248810759918648 1185 11838594 SGTC_2440 5628896 157.78 µM 0.677644320403714 0.311125424687421 no 1068 0.248998618862618 1234 5522048 SGTC_1050 3232-1156 69.3 µM 0.675807417275425 0.3116721015041 no 1069 0.249581462408536 1190 700529 SGTC_1018 4259-0013 28.1 µM 0.675597787730077 0.311734515330382 no 1070 0.249648023245128 1221 6801262 SGTC_2482 5981709 142.65 µM 0.675342259642946 0.311810602023345 no 1071 0.249729170374787 1212 877755 SGTC_669 0108-0021 26.2 µM 0.67440982668027 0.312088313752083 no 1072 0.250025398505485 1317 17201 SGTC_130 0136-0219 337.655 µM 0.673761297924492 0.312281531703227 no 1073 0.250231541923259 1193 234244 SGTC_2864 9034755 47.6 µM 0.672947623768092 0.312524024907321 no 1074 0.25049030640817 1230 4930451 SGTC_1506 4226-2149 212 µM 0.670632620119671 0.313214391933016 no 1075 0.251227298309042 1258 991114 SGTC_2952 9073731 13.78 µM 0.669592754790689 0.313524707966752 no 1076 0.251558716974819 1243 16457353 SGTC_2480 5767542 37.17 µM 0.668553755034028 0.313834897564532 no 1077 0.251890090325906 1237 2867358 SGTC_1714 st033236 13.627 µM 0.66615557095437 0.314551368949961 no 1078 0.252655833864175 1288 2916566 SGTC_55 0767-0285 6.563 µM 0.663386950732252 0.315379379487671 no 1079 0.253541380599468 1222 3116166 SGTC_678 1218-2179 85.9 µM 0.662648017641256 0.315600529090379 no 1080 0.253778004683559 1252 6820081 YOR116C RPO31 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.662382120818565 0.315680123470332 no 1081 0.253863179576412 1273 279621 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.662054409046193 0.315778233491346 no 1082 0.253968176329674 1222 2724278 An inhibitor of dopamine biosynthesis. SGTC_348 k064-0012 10.7 µM 0.66107700364055 0.316070925214286 no 1083 0.254281466044206 1191 5066323 SGTC_3030 9087619 49.47 µM 0.660992784817496 0.316096150600904 no 1084 0.254308470350588 1222 25236973 SGTC_257 daunorubicin 18.5 µM 0.659738120911004 0.316472051317076 no 1085 0.254710949453084 1294 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1182 1222-0449 220 µM 0.657022733126959 0.317286237947541 no 1086 0.255583149624368 1249 658318 SGTC_2657 nystatin 74.44 µM 0.656607691034749 0.317410762967282 no 1087 0.255716601148049 1266 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2201 6605497 169.863 µM 0.655229407936221 0.317824437266475 no 1088 0.256160031488648 1254 670741 SGTC_2676 harmalol 100 µM 0.655150510789235 0.317848124138847 no 1089 0.256185426927688 1263 5459187 A monoamine oxidase inhibitor SGTC_2565 isoliquiritigenin 100 µM 0.65406416775513 0.318174346905441 no 1090 0.256535232808489 1209 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.653740213934911 0.31827165575691 no 1091 0.256639595098368 1236 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.652993562361334 0.318495981798823 no 1092 0.256880214382436 1270 551469 SGTC_2029 5175081 200 µM 0.652859041669171 0.318536404641528 no 1093 0.256923578101304 1264 1380876 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.651505398839388 0.318943288178992 no 1094 0.257360146573084 1242 803109 SGTC_3097 9117246 49.47 µM 0.650712162752797 0.31918182382288 no 1095 0.257616155168571 1281 16423892 SGTC_2151 5563267 85.4165 µM 0.650498361521796 0.319246129242896 no 1096 0.25768517988285 1267 5310824 SGTC_1527 coumarin 137 µM 0.647864049167946 0.320038902406133 no 1097 0.258536442467815 1303 323 A hepatotoxic, DNA x-linker. SGTC_1970 st070122 35.8 µM 0.645518213642937 0.320745553493827 no 1098 0.259295709503918 1308 102928 SGTC_817 1391-0715 46 µM 0.645449255725869 0.320766335976782 no 1099 0.259318046252973 1242 1353946 SGTC_2708 st078559 56 µM 0.644324960037461 0.32110525453087 no 1100 0.25968236669256 1212 17250902 SGTC_2697 mebhydrolin 72.4 µM 0.640862224042729 0.322150030770966 no 1101 0.260806100545439 1297 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1515 3460-0031 42.1 µM 0.64043845889994 0.322277985918534 no 1102 0.260943793250271 1242 2876596 SGTC_1524 corynanthine 62.1 µM 0.639989842417287 0.322413467836304 no 1103 0.261089601550428 1330 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3092 9117248 49.47 µM 0.639795636127663 0.322472125340664 no 1104 0.261152735019977 1330 17141857 SGTC_920 mycophenolic acid 780.421 nM 0.636332251562113 0.323518937012212 no 1105 0.262279944037323 1289 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1468 k284-1086 134 µM 0.632897914186689 0.324558350189166 no 1106 0.26340015499745 1301 15996457 SGTC_1424 4048-1941 275 µM 0.632633612599073 0.324638398701431 no 1107 0.263486465909892 1353 X1424 SGTC_2920 7982904 15.77 µM 0.629826535469856 0.325489072032094 no 1108 0.264404041184334 1279 6456808 SGTC_2830 7992007 71.43 µM 0.628162440749954 0.325993799070766 no 1109 0.264948766089902 1272 1952075 SGTC_1812 st052057 4.327 µM 0.627652518354023 0.326148524605378 no 1110 0.265115798206368 1280 3645418 SGTC_1660 st012960 28.1 µM 0.623890325236709 0.327291008870216 no 1111 0.266349807226418 1278 24207266 SGTC_2293 7624732 200 µM 0.623552738637395 0.327393604856258 no 1112 0.266460678436389 1266 894453 SGTC_2032 5185112 25.99 µM 0.621369468976323 0.328057437168777 no 1113 0.267178277717487 1238 5718189 SGTC_1350 1495-0454 146 µM 0.61358060810425 0.330430089113709 no 1114 0.269746250561139 1366 1069057 SGTC_502 l-744,832 89.3 µM 0.608960463217468 0.331840718451207 no 1115 0.271275322753453 1301 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1270 0831-1170 17.3 µM 0.608938028379746 0.331847574128495 no 1116 0.271282758261289 1289 6764716 SGTC_3188 9110789 49.47 µM 0.607795177738545 0.332196882890495 no 1117 0.271661663996088 1360 849217 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.60767168365456 0.33223463721147 no 1118 0.271702623536365 1207 6708630 An antioxidant. SGTC_2996 9066192 71.4286 µM 0.6065001553199 0.332592878745138 no 1119 0.272091339621225 1298 6472854 SGTC_352 k048-0007 5.11 µM 0.606177018587408 0.332691717618423 no 1120 0.272198605840719 1296 6811911 SGTC_255 tunicamycin 200.472 nM 0.603792964359544 0.333421295012614 no 1121 0.272990648831168 1324 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1726 st035556 14.5795 µM 0.601724744197152 0.334054730629907 no 1122 0.273678688109279 1438 5919439 SGTC_1402 3909-7673 35.9 µM 0.601516937235994 0.334118402032162 no 1123 0.27374786710075 1322 5328014 SGTC_737 1950-0117 57.9 µM 0.599731786516954 0.334665563127548 no 1124 0.274342500272266 1304 5393513 SGTC_596 1155-0152 116 µM 0.599605462717535 0.334704295571242 no 1125 0.274384602838055 1329 280313 SGTC_2635 hydroquinidine 100 µM 0.599236185348469 0.334817530677349 no 1126 0.274507697890418 1362 442912 An experimental heart treatment. SGTC_343 4130-2827 29.8 µM 0.598575114557891 0.335020278743238 no 1127 0.274728127496395 1341 1118244 SGTC_756 0508-1999 28.3 µM 0.59815833595394 0.335148127981165 no 1128 0.274867144360217 1292 6753853 SGTC_1117 retinoic acid 1.10837 µM 0.597744969343992 0.335274949437396 no 1129 0.275005057387225 1400 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_726 3448-4391 34.2 µM 0.597185409938744 0.335446652958447 no 1130 0.275191799544953 1444 1356692 SGTC_3189 9110682 49.47 µM 0.595823047079599 0.335864844289542 no 1131 0.27564672275578 1384 17122418 SGTC_820 1582-0060 59.9 µM 0.589986046804816 0.337658867835902 no 1132 0.277600002067918 1331 3848840 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.589017379450927 0.337956949917723 no 1133 0.277924807577554 1339 688664 SGTC_2812 7970281 58.44 µM 0.587541993112731 0.338411156787127 no 1134 0.278419878025496 1444 2233435 SGTC_75 0159-0059 199.013 µM 0.587513670081452 0.338419878511608 no 1135 0.278429386108602 1469 5377270 SGTC_1396 3511-0007 98.6 µM 0.58360978054657 0.339622860220541 no 1136 0.279741439199363 1331 X1396 SGTC_2976 9009005 19.48 µM 0.583516886486271 0.339651505452052 no 1137 0.279772696347541 1423 2993148 SGTC_3173 9105693 49.47 µM 0.582654853955424 0.33991736984994 no 1138 0.280062835280982 1396 17096658 SGTC_973 1325-0077 65.9 µM 0.581768496174042 0.340190819582196 no 1139 0.280361313485482 1444 2835149 SGTC_2327 6189656 200 µM 0.58014801927804 0.34069096925483 no 1140 0.28090740190921 1443 5349088 SGTC_2313 7726885 200 µM 0.576737462583694 0.341744530092852 no 1141 0.282058410592084 1368 726423 SGTC_465 cgp-37157 41 µM 0.575823044150895 0.342027214740156 no 1142 0.282367397914707 1326 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3323 9138564 53.9225 µM 0.573236086985451 0.342827429747758 no 1143 0.283242426708988 1436 43912313 YNL103W MET4 SGTC_1463 k081-0032 34.1 µM 0.572835627930575 0.342951365600417 no 1144 0.283377996685876 1274 977755 SGTC_2184 6075246 200 µM 0.571992446160646 0.343212372491341 no 1145 0.283663546098875 1402 2267320 SGTC_1082 camptothecin 424.86 nM 0.571261954318423 0.343438556706321 no 1146 0.283911043650006 1282 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_36 0335-0881 14.2 µM 0.568490060400717 0.344297335446047 no 1147 0.284851126499456 1346 23828853 SGTC_696 1560-0013 611 µM 0.568250973118379 0.344371446354911 no 1148 0.284932282044819 1425 1650269 SGTC_2549 cedrol 20.94 µM 0.568138104415709 0.34440643482666 no 1149 0.284970597914769 1429 6708665 A sedative which affects the nervous system. SGTC_892 0929-0076 29 µM 0.568137818955375 0.344406523318963 no 1150 0.284970694823942 1375 5751038 SGTC_3122 9126309 49.47 µM 0.567803707077534 0.344510103369305 no 1151 0.28508413118343 1414 17591206 SGTC_2291 7917025 104.35 µM 0.567382780790419 0.344640613879793 no 1152 0.285227073067832 1337 2964612 SGTC_3341 9147222 25.867 µM 0.566964229746113 0.344770406271043 no 1153 0.285369242200145 1382 1939759 SGTC_142 0335-0849 62.6745 µM 0.566630398876045 0.344873940093995 no 1154 0.285482658640059 1414 3889043 YPR107C YTH1 SGTC_2780 5215298 71.43 µM 0.565973927771599 0.34507757096992 no 1155 0.285705752161617 1404 2834131 SGTC_673 1082-0474 110 µM 0.563816581495209 0.345747074297485 no 1156 0.286439482944129 1391 3098046 SGTC_2072 5231554 129 µM 0.563718513991381 0.345777519709683 no 1157 0.286472857726591 1445 789545 SGTC_2525 harmine 47.85 µM 0.563389573069532 0.345879647893818 no 1158 0.286584817881642 1429 5280953 A monoamine oxidase inhibitor SGTC_954 1189-0853 2.85 µM 0.563185398809325 0.345943044694355 no 1159 0.286654322202107 1370 2828194 SGTC_1530 rhein 70.4 µM 0.563046045296502 0.345986316912846 no 1160 0.286701765049332 1411 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2466 5983409 37.09 µM 0.56179936132194 0.346373528132582 no 1161 0.287126363652245 1389 2879657 SGTC_392 N-ethylmaleimide 8.33 µM 0.561545440896374 0.346452413720758 no 1162 0.287212880957497 1354 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_777 1315-0167 517 µM 0.56051112408642 0.346773814240005 no 1163 0.287565427084387 1343 4221767 SGTC_3245 9134821 49.47 µM 0.559227814971237 0.347172739194134 no 1164 0.288003126222636 1332 17014901 SGTC_805 3852-0218 479 µM 0.558206420682185 0.347490367322667 no 1165 0.28835171849002 1354 6615355 SGTC_337 1315-0038 354 µM 0.554817958377283 0.348544860554111 no 1166 0.289509591198042 1389 1626437 SGTC_2717 st081029 62.2815 µM 0.554146686567853 0.348753900361972 no 1167 0.289739230601344 1374 5292846 SGTC_1785 bathophenanthroline 24 µM 0.551596863160386 0.349548355331638 no 1168 0.290612293029118 1382 72812 An iron chelator. SGTC_1434 4073-0095 163 µM 0.550148784831034 0.34999983061391 no 1169 0.291108664032678 1399 24133745 SGTC_3184 9108758 49.47 µM 0.549599295232616 0.350171203538139 no 1170 0.291297121166182 1412 902885 SGTC_2881 9058953 51.95 µM 0.548730998350385 0.350442067176075 no 1171 0.291595034897398 1353 17122249 SGTC_2911 7942208 15.64 µM 0.548100295640732 0.350638861446543 no 1172 0.291811518802683 1371 1243384 SGTC_722 3534-0461 190 µM 0.546741050253893 0.351063114624422 no 1173 0.292278323833882 1383 658262 SGTC_2484 5809818 12.04 µM 0.546080493966229 0.351269357218638 no 1174 0.292505303725009 1420 2870548 SGTC_552 k242-0005 476 µM 0.544066576300377 0.351898424059595 no 1175 0.293197829848079 1421 4088318 SGTC_2389 9091542 195.52 µM 0.543463276544853 0.3520869496606 no 1176 0.293405434485382 1401 3626624 YOL127W RPL25 SGTC_424 splitomicin 100 mM 0.542672531297172 0.352334105304052 no 1177 0.293677645056842 1384 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3024 9090631 49.47 µM 0.5408600952153 0.352900836207031 no 1178 0.294302008801047 1412 25236383 SGTC_1765 st044815 90.4 µM 0.53904391149363 0.353469066527904 no 1179 0.294928277812049 1358 645695 SGTC_2354 9060492 162 µM 0.538412120095766 0.353666812087851 no 1180 0.295146280368701 1512 6471895 SGTC_379 3970-0972 5.9 µM 0.536254600865107 0.35434239545948 no 1181 0.295891301137085 1447 2898042 YBL034C STU1 SGTC_2078 5212016 200 µM 0.534248863184736 0.354970862951561 no 1182 0.296584683315606 1412 1899708 SGTC_153 4077-0274 519.67 µM 0.534210454318084 0.354982901645518 no 1183 0.296597968495735 1533 3121976 SGTC_980 1473-0395 201 µM 0.533862552459964 0.355091952956292 no 1184 0.296718316116269 1387 768876 SGTC_1980 st071811 45.7 µM 0.533227935268522 0.355290906972853 no 1185 0.296937903039591 1478 4974850 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.530581351697092 0.356121042044851 no 1186 0.297854460583165 1412 688803 SGTC_2896 9052656 71.43 µM 0.529458402545935 0.356473475979146 no 1187 0.298243746690686 1401 6469436 SGTC_3096 9117468 49.47 µM 0.528507050277505 0.356772150737488 no 1188 0.298573727497015 1368 41316311 SGTC_684 1140-0066 328 µM 0.527284339799476 0.357156146717332 no 1189 0.298998073796582 1413 6813534 SGTC_1605 st000082 49.1 µM 0.526903406401964 0.357275809606955 no 1190 0.29913033410803 1504 1114022 SGTC_294 k038-0071 157 µM 0.525766762286579 0.357632947854244 no 1191 0.29952513539168 1448 24152826 SGTC_3266 9136860 49.47 µM 0.525187483128005 0.357815007731198 no 1192 0.299726432678441 1394 4871271 YPR165W RHO1 SGTC_1572 epiandrosterone 68.9 µM 0.52467832856787 0.357975055076832 no 1193 0.299903412514603 1432 441302 A steroid. SGTC_2719 novobiocin 32.65 µM 0.523241607887259 0.358426807551624 no 1194 0.300403065021541 1519 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_962 1254-0300 21.5 µM 0.52298436645544 0.358507713700678 no 1195 0.300492566302132 1459 7340576 SGTC_2054 5233173 129 µM 0.522887908641147 0.358538052715146 no 1196 0.300526129699855 1481 6889 SGTC_475 α-linolenic acid 10 µM 0.521760305407866 0.358892785554546 no 1197 0.300918615288028 1519 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_16 erodoxin 22.806 µM 0.521150040949351 0.359084819513517 no 1198 0.301131126788856 1466 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2025 5147754 141 µM 0.520610189452666 0.359254726077823 no 1199 0.301319174837175 1488 315777 YLR208W SEC13 SGTC_2979 9012552 45.46 µM 0.519909991566208 0.35947513965927 no 1200 0.30156315554626 1493 17100905 SGTC_1436 4092-1007 8.32 µM 0.519211528681216 0.359695053674653 no 1201 0.301806620207158 1434 2881121 SGTC_1976 st070609 63.5 µM 0.516170920242745 0.360652942773041 no 1202 0.302867519271461 1425 682556 SGTC_1390 3413-2614 145 µM 0.515185754798861 0.360963489428773 no 1203 0.303211611233659 1450 3421432 SGTC_3070 9117005 49.47 µM 0.514649535973033 0.361132556396973 no 1204 0.303398971571334 1529 8779016 SGTC_873 0591-4978 488 µM 0.514419885067993 0.361204972416159 no 1205 0.303479229762927 1610 3305145 SGTC_405 ebelactone b 50 µM 0.511151892498615 0.362236009236533 no 1206 0.304622350896916 1455 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2734 clemastine 41.6 µM 0.510845759356033 0.362332644206658 no 1207 0.30472953218454 1475 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3249 9135183 49.47 µM 0.50888748690923 0.362951006091024 no 1208 0.30541554569407 1491 4902779 SGTC_2321 7390090 138.78 µM 0.506649159471303 0.363658238470381 no 1209 0.306200504439881 1406 649046 SGTC_2608 thymoquinone 42.66 µM 0.506262186187704 0.363780555550029 no 1210 0.306336302433964 1407 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_484 loperamide 105 µM 0.504029597306402 0.364486517798979 no 1211 0.307120289286545 1475 3955 An opioid-receptor agonist. SGTC_2425 5628681 7.85 µM 0.502290103808203 0.365036878283898 no 1212 0.307731734716731 1538 5714958 SGTC_1274 0865-0114 173 µM 0.502144649628145 0.365082911327541 no 1213 0.307782887220601 1493 870624 SGTC_858 0438-0351 2.77 µM 0.501980593840653 0.36513483370337 no 1214 0.307840585916134 1453 2799119 SGTC_1863 st057641 20.1 µM 0.501566478244092 0.365265909052576 no 1215 0.307986252199389 1472 3921635 SGTC_1217 1183-1422 255 µM 0.501154945936697 0.365396182336264 no 1216 0.308131039780146 1567 2849664 SGTC_2245 6637752 200 µM 0.499916630907521 0.365788272802758 no 1217 0.308566890704496 1587 681890 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.499136023710472 0.366035510306021 no 1218 0.308841780492517 1485 442882 SGTC_2957 9076800 11.52 µM 0.497734087785597 0.366479677529662 no 1219 0.309335739245019 1448 16459615 SGTC_1007 4101-0031 70 µM 0.497707427507647 0.366488125886043 no 1220 0.309345136082842 1574 1146276 SGTC_557 1315-0110 16.2 µM 0.496613375646628 0.366834874955925 no 1221 0.309730859502639 1434 6833801 SGTC_3214 9129694 49.47 µM 0.496016154762541 0.367024204168594 no 1222 0.309941506622894 1575 17158655 SGTC_1236 0330-0013 258 µM 0.495909555530966 0.367058001347479 no 1223 0.30997911204304 1473 4617066 SGTC_2713 st079149 53.4 µM 0.495325946941065 0.367243052116781 no 1224 0.310185029112804 1519 3103253 SGTC_302 1094-0063 18.9 µM 0.493730193109041 0.367749191510516 no 1225 0.310748369424133 1440 5440289 SGTC_1220 1838-0075 193 µM 0.492489686234123 0.36814281285524 no 1226 0.311186605634084 1503 5529645 SGTC_1232 0279-0259 161 µM 0.491461166118491 0.368469274363998 no 1227 0.311550155979978 1483 1560000 SGTC_3066 9117245 49.47 µM 0.491318196779641 0.368514661637772 no 1228 0.311600705818461 1586 17176980 SGTC_428 3448-4153 16.5 µM 0.49083341836707 0.368668573816973 no 1229 0.311772135924781 1424 3834874 SGTC_742 0kpi-0133 140 µM 0.489271442079301 0.369164628482715 no 1230 0.312324768216616 1582 2728852 SGTC_361 000s-0510 1.45 µM 0.488928582120372 0.369273543640313 no 1231 0.312446129769779 1501 660 SGTC_2427 5545055 42.75 µM 0.488755195553594 0.369328626757522 no 1232 0.312507510863108 1544 5372858 SGTC_66 0109-0187 42.4 µM 0.488608445683632 0.369375249768188 no 1233 0.312559466284905 1454 759417 SGTC_2008 4012253 172 µM 0.488300719382429 0.369473021861412 no 1234 0.312668426005667 1482 603940 SGTC_1433 4060-0023 7.6 µM 0.487497497861878 0.369728264537762 no 1235 0.31295290778822 1535 3840627 SGTC_751 0833-0568 350 µM 0.486843650102441 0.369936082554955 no 1236 0.313184567239245 1522 6954252 SGTC_2537 larixol 68.93 µM 0.486196344425891 0.370141858665604 no 1237 0.313413981469368 1556 6708759 SGTC_883 0850-0245 24.6 µM 0.485527969729547 0.370354371551679 no 1238 0.313650938631354 1577 6823229 YPR165W RHO1 SGTC_571 k831-0106 44.2 µM 0.484006917317186 0.37083814475954 no 1239 0.314190479970514 1586 4783639 SGTC_196 k015-0023 18.111 µM 0.483707641425414 0.370933354017235 no 1240 0.314296684673646 1495 5211998 SGTC_1556 plumbagin 1.48 µM 0.481963519957826 0.371488372027174 no 1241 0.314915930619507 1476 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2070 5230947 200 µM 0.48176815828654 0.371550557097807 no 1242 0.314985325749175 1565 2835538 SGTC_22 0964-0034 14.468 µM 0.480639645020971 0.371909836817513 no 1243 0.315386316828012 1460 138402 SGTC_1942 st076330 65.2 µM 0.47883401123007 0.372484920325142 no 1244 0.316028359385176 1519 24208414 SGTC_177 1327-0068 8.361 µM 0.477980362116749 0.372756901535517 no 1245 0.316332091150281 1484 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1740 st038286 13.222 µM 0.476315071534109 0.373287662406804 no 1246 0.316924964806125 1556 716786 SGTC_364 0083-0097 67.7 µM 0.4758149222422 0.373447116837688 no 1247 0.317103118950606 1547 5207356 SGTC_354 2783-3500 4.88 µM 0.475042312763776 0.373693477887014 no 1248 0.317378407269489 1442 6740761 SGTC_382 3229-0966 23.2 µM 0.472717942156933 0.374434958008486 no 1249 0.318207212082982 1602 5722370 SGTC_819 1013-0258 27.7 µM 0.472067676946533 0.374642477551306 no 1250 0.318439241524224 1506 5753198 SGTC_905 2-aminofluorene 215 µM 0.470160515226006 0.375251320477939 no 1251 0.319120170841864 1518 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1329 1447-1697 50.6 µM 0.470069235903765 0.375280468326706 no 1252 0.319152776366745 1506 2840515 SGTC_2730 imipramine 71.33 µM 0.46967371990316 0.375406775042568 no 1253 0.319294073231643 1544 3696 A tricyclic antidepressant. SGTC_847 0342-0274 5.54 µM 0.469224182700653 0.375550349467058 no 1254 0.319454700875604 1623 18097 SGTC_583 1488-1091 88.9 µM 0.466478585228099 0.376427619365205 no 1255 0.320436486276187 1595 4303273 SGTC_1956 st077085 54 µM 0.465721218419787 0.376669724851477 no 1256 0.320707531200675 1506 24208685 SGTC_1442 4112-3290 3 µM 0.464390721508809 0.377095158778817 no 1257 0.321183918248784 1519 704353 SGTC_2485 5633444 17.78 µM 0.463773427547339 0.377292592735826 no 1258 0.321405041604305 1482 5724239 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.463682026018143 0.377321829129667 no 1259 0.321437788297091 1539 165521 SGTC_2587 piperic acid 92.2 µM 0.463074376256797 0.377516214508995 no 1260 0.321655528025174 1496 5370536 SGTC_2688 kanamycin b 96.69 µM 0.462758572179402 0.377617251565903 no 1261 0.321768714609479 1523 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2617 dihydrotanshinone i 20.83 µM 0.461002774202855 0.378179146889462 no 1262 0.32239830737577 1509 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_329 k048-0121 21.3 µM 0.457259770699694 0.379377852315795 no 1263 0.323742170786846 1544 6832902 SGTC_2154 5570129 200 µM 0.455941319090908 0.379800366442907 no 1264 0.324216088015839 1535 673366 SGTC_3324 9138759 60.749 µM 0.453198287900844 0.380679864153918 no 1265 0.325202982597203 1553 45595710 SGTC_1682 st012968 530 nM 0.452969526804493 0.380753239727984 no 1266 0.325285342373264 1491 24207270 SGTC_2531 methyl deoxycholate 70.07 µM 0.449148747444018 0.381979394435053 no 1267 0.326662178537668 1514 16667744 Haematoxylin. SGTC_1161 k007-0610 110 µM 0.448866094195411 0.382070150006146 no 1268 0.32676412813105 1595 5843850 SGTC_2023 5144124 124 µM 0.447551119042559 0.382492453247953 no 1269 0.327238593666003 1529 2830192 SGTC_1548 st061468 90.8 µM 0.446952930047798 0.382684607463426 no 1270 0.32745452296117 1587 390799 SGTC_204 PMA1.184 62.41 µM 0.445615559895048 0.383114310733101 no 1271 0.327937484482966 1554 2252213 YGL008C PMA1 SGTC_3104 9120930 49.47 µM 0.445525366605276 0.383143295442104 no 1272 0.32797006615684 1555 17014836 SGTC_2198 6589944 200 µM 0.443755872361432 0.383712076037874 no 1273 0.328609547706032 1588 5290268 SGTC_1457 k015-0032 57.3 µM 0.441736808744055 0.384361383533211 no 1274 0.329339835209053 1553 4302660 SGTC_2714 st079313 56.9 µM 0.439566920382889 0.385059556392069 no 1275 0.330125401835539 1569 2939799 SGTC_809 3998-0021 90 µM 0.43896717649502 0.385252592959142 no 1276 0.330342660011064 1616 715485 SGTC_1197 1601-0112 267 µM 0.438725362430016 0.385330432489973 no 1277 0.330430273725671 1529 7350313 SGTC_2817 7995342 71.43 µM 0.438450336085215 0.385418968611418 no 1278 0.330529932162316 1479 18879975 SGTC_2993 9054257 71.4286 µM 0.437857790765831 0.385609740313233 no 1279 0.330744687479798 1529 6470217 YGL055W OLE1 SGTC_948 3448-0295 75.3 µM 0.437216532114926 0.385816226596124 no 1280 0.330977160681341 1559 678569 SGTC_304 1310-0298 97 µM 0.43626110255189 0.386123936406939 no 1281 0.331323650031369 1524 1550234 SGTC_412 gemfibrozil 100 µM 0.435855894687748 0.386254461066628 no 1282 0.331470643497012 1586 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_123 0083-0120 66.675 µM 0.434754597316428 0.386609273538574 no 1283 0.331870281957462 1506 16001701 SGTC_1876 myriocin 605 nM 0.434725234399258 0.386618734888444 no 1284 0.331880939785264 1673 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1743 st037606 46.3785 µM 0.433809771493168 0.386913750082917 no 1285 0.332213292617416 1578 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2137 5261020 140 µM 0.433730328206864 0.386939354397007 no 1286 0.332242140212373 1565 763655 SGTC_144 4161-2749 112.381 µM 0.432998770839867 0.387175156082381 no 1287 0.332507831396778 1502 797501 YMR168C CEP3 SGTC_2981 9013952 38.96 µM 0.43045829729636 0.387994345612546 no 1288 0.333431148065029 1479 2996344 SGTC_3134 9127454 49.47 µM 0.427776829802438 0.388859540356072 no 1289 0.334406803783482 1625 24262820 SGTC_190 3970-0790 3.722 µM 0.425426508494096 0.389618342142334 no 1290 0.335262892585299 1644 2832352 SGTC_2005 4024620 188 µM 0.424749238912569 0.389837077045601 no 1291 0.335509742617411 1567 236743 SGTC_2446 5162541 200 µM 0.424424783381839 0.389941877447701 no 1292 0.335628024769015 1557 1549321 SGTC_1138 3761-0006 1.03 µM 0.423511755816087 0.390236831826302 no 1293 0.335960961662887 1604 12061087 SGTC_1142 3253-1408 9.78 µM 0.421681291830463 0.390828355061476 no 1294 0.336628830764657 1621 256655 SGTC_3035 9091303 49.47 µM 0.420469594229812 0.391220060058754 no 1295 0.337071218524937 1604 25237002 SGTC_700 3453-2283 142 µM 0.420089962949824 0.391342806033128 no 1296 0.337209867361597 1676 565664 SGTC_1977 st070720 65.3 µM 0.418175517385904 0.391961967320687 no 1297 0.337909397270619 1575 682188 SGTC_38 0929-0051 58.268 µM 0.417465006673466 0.392191827189737 no 1298 0.338169157390292 1752 1379719 SGTC_2647 atorvastatin 60.16 µM 0.412982259273232 0.393642921312909 no 1299 0.339809805837967 1662 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3124 9127567 49.47 µM 0.412185903150592 0.393900862116606 no 1300 0.340101584383517 1721 17592030 SGTC_1893 st059353 36.1 µM 0.412147636428581 0.393913257931719 no 1301 0.340115607419226 1566 3112488 SGTC_2261 9010538 184.68 µM 0.411773599515489 0.394034426108347 no 1302 0.340252686799656 1532 6457250 SGTC_2855 9016525 58.44 µM 0.411083150937608 0.394258121865128 no 1303 0.340505782149746 1566 43811474 SGTC_376 3970-0862 59.1 µM 0.409786164167285 0.39467842183182 no 1304 0.340981408272168 1705 3135186 SGTC_172 1112-0046 2.638 µM 0.409648112726571 0.394723165843949 no 1305 0.341032048879651 1619 2802135 YIL048W NEO1 SGTC_132 0417-1715 25.805 µM 0.408727320741342 0.39502164029422 no 1306 0.341369890868259 1760 6769098 SGTC_1366 1683-0113 21.9 µM 0.408056411690592 0.395239154076751 no 1307 0.341616129983722 1598 708623 SGTC_3019 9081971 49.47 µM 0.407819077581925 0.395316107407952 no 1308 0.341703253231099 1718 16451803 SGTC_2200 6600604 21.907 µM 0.406431758173143 0.39576601413962 no 1309 0.342212694476708 1591 2904777 SGTC_98 0074-0023 107.663 µM 0.405664641266436 0.396014849308822 no 1310 0.342494512931577 1561 3563821 SGTC_2748 diazoxide 86.69 µM 0.405442872069062 0.396086794062334 no 1311 0.342576001417227 1664 3019 A potassium channel activatior. SGTC_2849 9019321 12.99 µM 0.405295180407133 0.396134709083103 no 1312 0.342630274379877 1640 16489627 SGTC_734 2023-0417 80 µM 0.405111664117044 0.396194248732235 no 1313 0.342697716516619 1674 3935732 SGTC_1326 1431-2094 10.8 µM 0.403059460916839 0.396860225967317 no 1314 0.343452241187416 1577 616278 SGTC_712 r015-0009 80.6 µM 0.402474698857803 0.397050047058162 no 1315 0.343667352541999 1687 6813872 YLR060W FRS1 SGTC_952 1185-0122 232 µM 0.401691211099154 0.397304415228154 no 1316 0.343955646755042 1578 678600 SGTC_2171 5739187 198.077 µM 0.400872438804285 0.39757028560087 no 1317 0.344257021324767 1566 2262761 SGTC_1226 3909-7979 35.4 µM 0.399077629703305 0.398153259353362 no 1318 0.344918002450194 1734 6615510 SGTC_1888 azatryptophan 97.5 µM 0.398816517720544 0.398238090380042 no 1319 0.345014202651344 1602 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2674 ligustilide 100 µM 0.398452203138201 0.398356458285347 no 1320 0.345148442016977 1636 5319022 A signalling regulator. SGTC_2716 st080858 38.6235 µM 0.397982307271815 0.398509143967952 no 1321 0.34532161380171 1699 5296050 SGTC_693 4161-2696 114 µM 0.397967437912201 0.39851397579924 no 1322 0.345327094169212 1720 805759 SGTC_2256 7954252 200 µM 0.397564143100994 0.398645033270939 no 1323 0.345475748024582 1614 2972920 SGTC_854 0422-0053 192 µM 0.397501048090594 0.398665538096382 no 1324 0.345499006906483 1590 3596728 SGTC_1710 st031758 61.5 µM 0.396906248538813 0.398858851765023 no 1325 0.345718298110725 1707 5394341 SGTC_2464 5717415 7.67 µM 0.396162875613994 0.39910048761205 no 1326 0.345992438255905 1542 5285744 SGTC_533 1222-0222 6.71 µM 0.396094891627845 0.399122587964623 no 1327 0.346017513337805 1734 3982874 SGTC_3349 9149703 23.001 µM 0.395894869559262 0.399187613361883 no 1328 0.346091293006081 1595 4910494 SGTC_282 k297-0036 65.7 µM 0.395068085681781 0.399456423113965 no 1329 0.346396320516585 1672 5061378 SGTC_458 nppb 133 µM 0.393812217079064 0.399864831055129 no 1330 0.346859841947314 1776 4549 A chloride channel blocker. SGTC_921 1561-0023 372 µM 0.393615725490751 0.399928739960405 no 1331 0.346932384675508 1590 24050882 SGTC_668 1682-0499 62.6 µM 0.393596611367234 0.399934956973739 no 1332 0.346939441718131 1623 682214 SGTC_932 2857-0803 154 µM 0.393293677138927 0.400033492009634 no 1333 0.347051293837542 1742 674898 SGTC_2 0422-0095 29 µM 0.391506712650075 0.400614865016499 no 1334 0.347711363937067 1621 6790840 SGTC_2241 6772625 37.8075 µM 0.38926302867213 0.401345139375074 no 1335 0.348540791303162 1586 2285411 SGTC_1419 3993-2473 62.6 µM 0.388751774670241 0.401511590669035 no 1336 0.348729889154543 1675 704026 SGTC_1445 4239-0156 97.7 µM 0.387090061849707 0.402052725379453 no 1337 0.349344767366362 1771 4008346 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.385092369392614 0.402703519965222 no 1338 0.350084490619417 1688 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2353 9059630 146.67 µM 0.38487409868387 0.40277464307944 no 1339 0.350165348374071 1716 4779114 SGTC_574 1315-0397 40 µM 0.383314058224869 0.403283072977361 no 1340 0.350743458445166 1632 6794277 SGTC_537 1334-0398 209 µM 0.382132350410334 0.403668310086276 no 1341 0.351181598606904 1773 5846986 SGTC_664 1222-0054 14.9 µM 0.378154442372445 0.404965794206196 no 1342 0.35265793331036 1656 6813991 SGTC_1864 st057645 30.4 µM 0.37814465663429 0.404968987339484 no 1343 0.352661567873642 1714 688666 SGTC_2951 9072950 58.06 µM 0.377677183603592 0.405121533398127 no 1344 0.352835209713455 1690 16488155 SGTC_3156 9099931 49.47 µM 0.375651353379383 0.405782769764782 no 1345 0.353588053850652 1688 18111053 SGTC_468 gf-109203x 121 µM 0.375003547295173 0.405994272226579 no 1346 0.353828914248374 1745 2396 A protein kinase C inhibitor. SGTC_1139 k015-0024 46.9 µM 0.371646963406761 0.407090602728682 no 1347 0.355077858938135 1775 2766652 SGTC_3079 9117512 49.47 µM 0.368322343484046 0.408177211219668 no 1348 0.356316447043291 1735 7185044 SGTC_627 1391-0720 175 µM 0.367835665774002 0.408336334936465 no 1349 0.356497886585799 1674 997839 SGTC_2654 protoveratrine a 100 µM 0.367262770913725 0.408523667504993 no 1350 0.356711510583802 1689 5702278 A heart drug and vasodilator. SGTC_1802 st050112 57.9 µM 0.367016410156458 0.408604232160795 no 1351 0.356803388682085 1674 4662563 SGTC_3178 9107506 49.47 µM 0.366142615871006 0.408890010642448 no 1352 0.357129329604772 1706 8897194 SGTC_591 4299-0174 154 µM 0.365130562423946 0.409221067963255 no 1353 0.357506974013009 1700 5509088 SGTC_1304 1165-0502 251 µM 0.364561632460472 0.409407201632542 no 1354 0.357719329661688 1699 767425 SGTC_2851 9015922 71.43 µM 0.364052777562688 0.409573698179375 no 1355 0.357909299343577 1764 2996893 SGTC_1721 st082152 9.2685 µM 0.363675449217905 0.409697169971319 no 1356 0.358050189233759 1629 5296051 SGTC_1337 1486-1011 40.3 µM 0.363160911976268 0.409865554566542 no 1357 0.35824234244077 1656 X1337 SGTC_290 2043-6722 48.1 µM 0.361820572839957 0.410304264476714 no 1358 0.358743058694256 1704 773758 YLR208W SEC13 SGTC_1430 4049-0248 69.1 µM 0.359399131286899 0.411097117129935 no 1359 0.359648262254124 1779 22774488 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.358136252726196 0.411510765833949 no 1360 0.360120675085828 1633 5355888 SGTC_2418 pentamidine 31.67 µM 0.357327718952256 0.411775648165953 no 1361 0.360423240593381 1617 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1490 4089-0339 670 nM 0.357031471247424 0.411872711428611 no 1362 0.360534122837792 1797 742542 SGTC_2818 7996756 12.99 µM 0.356608750352066 0.412011221986571 no 1363 0.360692362906802 1662 2241621 SGTC_2936 9038235 15.59 µM 0.353187801555307 0.413132546759565 no 1364 0.361973826152864 1666 4749415 SGTC_2963 9082507 9 µM 0.351655278774571 0.413635110360554 no 1365 0.362548401615865 1742 16459611 SGTC_2575 plumbagin 510 nM 0.348504626981411 0.414668754244391 no 1366 0.363730619771832 1630 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1265 0819-1001 68.8 µM 0.348024988631683 0.414826162673092 no 1367 0.363910708497902 1678 3106768 SGTC_2522 biochanin a 4.94 µM 0.345869977064761 0.415533565996582 no 1368 0.364720216281722 1767 5280373 A possible chelator. SGTC_746 1095-0025 46.6 µM 0.342480679571299 0.416646688781779 no 1369 0.365994590676453 1790 6749286 SGTC_1842 st055362 61.2 µM 0.341158978486895 0.41708094735727 no 1370 0.366491951562261 1773 676032 SGTC_2564 betulinic acid 100 µM 0.340761257604781 0.417211642499518 no 1371 0.366641659305923 1922 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2246 7293507 91.5585 µM 0.339905391190073 0.417492919947938 no 1372 0.366963888269654 1872 887656 SGTC_1979 st071809 45.3 µM 0.338687590458524 0.417893218570042 no 1373 0.367422545056671 1786 4976333 SGTC_2258 7960471 200 µM 0.338005946834864 0.418117316205957 no 1374 0.367679353167885 1698 2974708 SGTC_1693 xanthone 101.9 µM 0.337169623186618 0.418392302868551 no 1375 0.36799451755353 1778 7020 An insecticide. SGTC_1250 0485-0349 40.2 µM 0.336584215656357 0.418584811019244 no 1376 0.368215178349453 1686 6842794 YDL195W SEC31 SGTC_166 k072-0058 166.424 µM 0.336204714324859 0.418709618433536 no 1377 0.368358249054482 1826 5846229 SGTC_2435 5706476 10.6 µM 0.335915167542037 0.418804847807111 no 1378 0.368467419480694 1880 5725375 SGTC_902 1120-0002 2.07 µM 0.335904696277863 0.418808291802377 no 1379 0.368471367754553 1683 3280475 SGTC_2107 5363541 170.161 µM 0.334910880317403 0.419135185821902 no 1380 0.36884615715789 1746 244052 SGTC_3093 9117344 49.47 µM 0.334089915771051 0.419405266269852 no 1381 0.369155854687038 1744 24824913 SGTC_1516 st013856 110 µM 0.3336821694835 0.419539420533089 no 1382 0.369309702925601 1730 5281404 A mutagen and neurotoxin. SGTC_1758 st042942 75.2445 µM 0.332255044500185 0.420009038277646 no 1383 0.369848341362895 1798 669317 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.332152344882805 0.42004283759105 no 1384 0.369887113047824 1691 16623 A steroid. SGTC_303 1348-1668 34.2 µM 0.330498341951611 0.420587265016684 no 1385 0.370511722620918 1771 5380509 SGTC_2802 7925815 54.55 µM 0.330434181463895 0.420608386988645 no 1386 0.370535958764532 1688 1262923 SGTC_2315 7733312 200 µM 0.328953760285953 0.421095812835884 no 1387 0.371095319302146 1685 726316 SGTC_3135 9127742 49.47 µM 0.327146657941228 0.421690961716169 no 1388 0.371778481836456 1701 3643468 SGTC_2627 acetyl isogambogic acid 100 µM 0.327136829366843 0.421694199137276 no 1389 0.371782198567399 1644 6857789 A caspase activator and apoptosis inducer. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.326640971478701 0.421857535975147 no 1390 0.371969725532861 1745 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1945 st075991 56.6 µM 0.326532693604688 0.421893204768971 no 1391 0.372010678850226 1694 1084980 SGTC_2377 9073351 62.6 µM 0.325449299275942 0.422250130726211 no 1392 0.372420524508969 1692 7337946 YHR072W ERG7 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.323755722815468 0.422808209977735 no 1393 0.373061490106453 1809 5377381 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.323352651125097 0.422941055872624 no 1394 0.373214091956555 1763 688788 SGTC_580 1123-0028 41 µM 0.323209848419996 0.422988123432287 no 1395 0.373268161446808 1779 1677248 YPR107C YTH1 SGTC_801 0866-0028 10.1 µM 0.323166797977954 0.423002313009774 no 1396 0.373284462156065 1749 6849771 SGTC_2000 st075254 36.4 µM 0.321534108909095 0.423540526649576 no 1397 0.373902834101473 1721 17234175 SGTC_2224 6650123 117.647 µM 0.321080372814086 0.423690125490306 no 1398 0.374074741857037 1750 2908370 SGTC_1300 1094-0077 113 µM 0.32010005545666 0.424013378079378 no 1399 0.374446241811476 1715 5532636 SGTC_1683 st010134 710 nM 0.319876373106981 0.424087142895615 no 1400 0.374531024569753 1673 3818134 SGTC_1056 3448-1962 115 µM 0.319793568373806 0.424114450489804 no 1401 0.374562411748394 1773 715507 SGTC_2339 9000433 200 µM 0.31947070728887 0.424220928068975 no 1402 0.37468480035277 1672 2988954 SGTC_1861 st057647 17.4 µM 0.318657970798625 0.424488987982912 no 1403 0.374992944397894 1879 688668 SGTC_2420 aureobasidin a 50 nM 0.318443325392683 0.424559789002244 no 1404 0.375074339215016 1887 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1346 1488-2224 62.4 µM 0.317921815034113 0.42473181989536 no 1405 0.375272122224865 1883 3722427 SGTC_2810 7959871 45.46 µM 0.317224035780398 0.42496201911998 no 1406 0.37553680656969 1804 2974535 SGTC_2786 7743617 45.45 µM 0.31647844088929 0.425208021128982 no 1407 0.375819693280867 1673 583674 SGTC_1867 st057372 64 µM 0.316276155657762 0.425274768261713 no 1408 0.375896453989777 1759 688837 SGTC_1990 st072050 59.8 µM 0.316244037328437 0.425285366397043 no 1409 0.375908642309783 1707 17233948 SGTC_939 1165-0479 45.3 µM 0.315951117302999 0.425382024166266 no 1410 0.376019805827002 1875 1377347 SGTC_3264 9137442 49.47 µM 0.314489590651007 0.425864365730136 no 1411 0.37657461058879 1850 17015726 SGTC_2696 st077691 74.316 µM 0.313008285012997 0.426353348079201 no 1412 0.377137183841183 1777 757133 SGTC_1164 k060-0068 93.7 µM 0.312527680110567 0.426512021212546 no 1413 0.377319765054141 1760 5963676 SGTC_874 0599-0792 117 µM 0.310624325888716 0.427140535845017 no 1414 0.378043116006958 1918 765305 SGTC_1290 0986-0249 10.2 µM 0.310175036379515 0.427288924678155 no 1415 0.378213926539393 1841 53329 SGTC_318 1488-0629 67.2 µM 0.3094838365247 0.427517230392186 no 1416 0.378476752828536 1741 3662576 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.309099186354572 0.427644292198028 no 1417 0.378623039048583 1753 115019 SGTC_3037 9091026 49.47 µM 0.308237866156931 0.427928840002492 no 1418 0.378950670592413 1808 25236398 YIL048W NEO1 SGTC_3316 9136639 10.545 µM 0.305834890782493 0.428722890418383 no 1419 0.379865180743457 1832 4903665 SGTC_2040 5100729 123 µM 0.303715932199501 0.429423328564184 no 1420 0.380672159451551 1815 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_448 monastrol 171 µM 0.303504001171576 0.429493396266772 no 1421 0.380752899348647 1822 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2109 5483026 200 µM 0.300781406939185 0.430393725174041 no 1422 0.381790593684247 1792 759335 SGTC_3169 9102970 49.47 µM 0.297623519809196 0.43143845329855 no 1423 0.382995260714905 1815 17027839 SGTC_2148 5546263 113.568 µM 0.295667637248295 0.432085761696736 no 1424 0.383741957229399 1801 792097 SGTC_1820 st053765 18.6 µM 0.294334674846045 0.432527016381206 no 1425 0.384251089411482 1742 3690829 SGTC_2614 arthonioic acid 13.39 µM 0.293513302001587 0.432798959929585 no 1426 0.384564916740332 1750 6710684 SGTC_139 0099-0334 718.624 µM 0.292604252267402 0.433099969012547 no 1427 0.384912331562067 1913 97690 SGTC_2945 9067681 61.76 µM 0.292337899390444 0.433188172466754 no 1428 0.385014142122288 1831 16456930 SGTC_2474 5321570 43.32 µM 0.292034013723889 0.433288809067259 no 1429 0.385130308874795 1894 2841384 SGTC_640 3381-0960 37.1 µM 0.291989937579906 0.433303405946909 no 1430 0.385147158773633 1859 1745025 SGTC_2215 7188065 200 µM 0.291705503729932 0.433397605273484 no 1431 0.385255900395962 1878 940217 SGTC_584 0986-0246 15.4 µM 0.290355498825918 0.433844753894255 no 1432 0.385772142332564 1875 53315 YDR232W HEM1 SGTC_630 4356-0227 183 µM 0.289865272960307 0.434007147490725 no 1433 0.385959654863484 1811 779312 SGTC_1910 st062352 60.4 µM 0.288673648967185 0.434401934591627 no 1434 0.38641556483444 1718 2245730 SGTC_558 k064-0027 21.3 µM 0.286470474115252 0.43513202227626 no 1435 0.387258902263433 1857 5088526 SGTC_800 3448-7362 155 µM 0.286060894049992 0.435267773302394 no 1436 0.387415741269973 1829 15991913 SGTC_1045 1348-1485 165 µM 0.285974961461883 0.435296255728198 no 1437 0.387448649456871 1833 6810614 SGTC_1860 st056228 74.6 µM 0.28521035512766 0.435549699881079 no 1438 0.387741493727094 1767 688679 SGTC_3051 9093778 49.47 µM 0.284314310112026 0.435846745714709 no 1439 0.388084760289561 1851 17217378 SGTC_2292 7671323 168.05 µM 0.283739358168361 0.436037365792272 no 1440 0.388305065145057 1791 937504 SGTC_1047 2043-3044 82 µM 0.282831347242275 0.436338438786106 no 1441 0.388653061689976 1746 669592 SGTC_3163 9099914 49.47 µM 0.282701352653543 0.436381544660066 no 1442 0.388702889630743 1883 16268368 SGTC_775 4577-0580 57.3 µM 0.279788114295452 0.437347764321628 no 1443 0.389820035544235 1869 2006902 SGTC_2790 5423970 71.43 µM 0.279612541485329 0.437406007704885 no 1444 0.389887392027348 1910 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1761 st044296 37 µM 0.279015756689232 0.437603991349391 no 1445 0.390116366340823 1769 1826700 SGTC_1811 st050069 61.5 µM 0.278998957970849 0.437609564558637 no 1446 0.390122812223039 1961 3877702 SGTC_1308 1187-1617 41.4 µM 0.278394895851592 0.437809978812867 no 1447 0.390354618614416 1795 2882570 SGTC_3150 9097574 49.47 µM 0.278041101779943 0.437927367157575 no 1448 0.390490403764791 1925 17217476 SGTC_1629 st005085 44.9 µM 0.277290602366932 0.438176399814592 no 1449 0.390778487490276 1739 24207091 SGTC_1797 st048695 56.8 µM 0.275355937091264 0.438818478129136 no 1450 0.391521396559834 1922 592262 YIL048W NEO1 SGTC_122 0236-0016 402.397 µM 0.274764229373152 0.439014886813181 no 1451 0.391748690761785 1817 6808838 SGTC_1058 3448-5425 97.3 µM 0.272965645917148 0.439611992164973 no 1452 0.392439811822797 1910 7279705 SGTC_3212 9128307 49.47 µM 0.270699969174878 0.440364361568294 no 1453 0.3933109002599 1648 27243542 SGTC_506 n9-isopropylolomoucine 153 µM 0.270511943142295 0.440426809596588 no 1454 0.393383215008359 1996 6610355 SGTC_1287 0971-0001 34.6 µM 0.268225031628964 0.441186466806612 no 1455 0.394263054131206 1859 4665869 SGTC_719 2810-4230 27.3 µM 0.267936240060878 0.441282411895429 no 1456 0.394374198842784 1845 721079 SGTC_1982 st072467 71.9 µM 0.266926869593014 0.441617781612945 no 1457 0.394762734025256 1803 3163533 SGTC_1374 2889-5571 141 µM 0.266825107508738 0.441651595035435 no 1458 0.394801910939517 1805 2853281 SGTC_1385 3091-4834 14.1 µM 0.265761091342719 0.442005170882462 no 1459 0.395211605242444 1895 4072814 SGTC_3116 9124943 49.47 µM 0.265666968226658 0.442036450512457 no 1460 0.395247852479682 1736 41905195 YPL160W CDC60 SGTC_2871 9038510 12.99 µM 0.264164992488656 0.442535646010898 no 1461 0.395826392555791 1984 4945164 SGTC_2165 5727197 32.143 µM 0.263908956173711 0.442620751168335 no 1462 0.395925037106471 1872 1361712 SGTC_3320 9137005 35.139 µM 0.263518557001374 0.442750522945597 no 1463 0.396075461219203 1820 4908713 SGTC_3123 9126162 49.47 µM 0.262810636992758 0.44298585682192 no 1464 0.396348268264071 1809 25239884 SGTC_105 0111-0055 734.78 µM 0.262677348653668 0.443030168122391 no 1465 0.396399638503632 1858 5179370 SGTC_1235 benzylparaben 21.5 µM 0.258211072703869 0.444515376426091 no 1466 0.398122006419155 1864 7180 SGTC_1703 st026983 48.3 µM 0.253308445685947 0.446146584849783 no 1467 0.400014935090246 1983 1104023 SGTC_1633 st005664 67.9 µM 0.251280149050662 0.446821710582307 no 1468 0.40079876082922 1823 2063822 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.250379364919815 0.447121589324476 no 1469 0.401146992957299 1820 5282362 SGTC_1854 st056233 32.9 µM 0.250268984486806 0.447158337997654 no 1470 0.401189670090348 2002 5393174 SGTC_1887 st057648 70.8 µM 0.247302873075936 0.44814600671622 no 1471 0.402336917721409 1994 688672 SGTC_2722 naftopidil 47.16 µM 0.24636179087267 0.44845943985634 no 1472 0.402701090647027 1948 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_15 0266-0086 27.098 µM 0.246348718235135 0.448463794004648 no 1473 0.402706149993498 2003 1712902 YIL048W NEO1 SGTC_3111 9122088 49.47 µM 0.245165186984217 0.448858022484953 no 1474 0.403164265342533 1972 16876704 SGTC_1027 k015-0025 8.67 µM 0.245007228210599 0.448910641609257 no 1475 0.40322541730252 1808 3598955 SGTC_1185 1319-0113 81.3 µM 0.24408919947032 0.449216472507116 no 1476 0.403580868590881 1914 4672763 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.243646314057548 0.449364025576859 no 1477 0.403752377770798 1870 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1753 st043925 64 µM 0.243193033969642 0.44951504901927 no 1478 0.403927931495533 1993 670181 SGTC_2860 9025725 38.96 µM 0.242613089813886 0.449708284940488 no 1479 0.404152569967932 1789 40546248 SGTC_334 1502-1024 68.5 µM 0.242454959713279 0.44976097555996 no 1480 0.404213826360044 1907 3296216 SGTC_2237 6667747 47.222 µM 0.241833159291599 0.449968174607636 no 1481 0.404454721986549 1823 729940 YDL015C TSC13 SGTC_3161 9100388 49.47 µM 0.2403784843656 0.450452960912052 no 1482 0.405018428139982 1923 25236368 SGTC_252 miconazole 1.30953 nM 0.240351958552421 0.450461801617529 no 1483 0.405028709084018 1941 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2768 sulfasalazine 50.2 µM 0.240339470491598 0.450465963732851 no 1484 0.40503354926198 1991 5384001 An antioxidant and salicylic acid derivative. SGTC_2909 7941780 10.49 µM 0.238074354445363 0.451220988387164 no 1485 0.405911712558184 2027 1243215 SGTC_3186 9110464 49.47 µM 0.234057468785592 0.4525603577548 no 1486 0.407470181926639 1973 17018021 SGTC_2569 tetrandrine 100 µM 0.233277204229088 0.452820588198817 no 1487 0.40777307936711 1814 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2299 7976368 114.88 µM 0.232642125687237 0.453032411799025 no 1488 0.408019656542038 1980 2979718 SGTC_2149 5554786 194.827 µM 0.23246433949701 0.453091712862958 no 1489 0.408088690781965 1880 745063 YPR165W RHO1 SGTC_1859 st055998 20 µM 0.232280306937586 0.453153098522091 no 1490 0.408160153487486 2033 676301 SGTC_1734 st037168 69.4 µM 0.23214242329414 0.453199091543005 no 1491 0.408213697853046 1825 708907 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.231537967315761 0.45340072370304 no 1492 0.408448446500991 1910 16486 A toxic proline analog. SGTC_1641 st009299 47.1 µM 0.230130276358178 0.453870342455977 no 1493 0.408995269527306 1979 4046054 SGTC_2921 7974240 10.71 µM 0.230062545145281 0.453892939848202 no 1494 0.409021584455981 1935 2979074 YDR527W RBA50 SGTC_3164 9100705 49.47 µM 0.227251250977249 0.454831012179802 no 1495 0.410114188743953 1988 17174235 SGTC_1989 st071868 50.2 µM 0.226529197370772 0.455071987823677 no 1496 0.410394926573422 2017 16414057 SGTC_1856 st057054 55.7 µM 0.224298012776042 0.455816719653449 no 1497 0.411262711197602 2028 1266018 SGTC_2086 5274770 176.623 µM 0.223953830509295 0.455931615784496 no 1498 0.411396614325179 1902 689278 SGTC_2618 avocadyne 43.43 µM 0.222865654437956 0.456294898735784 no 1499 0.411820033949927 1931 3015189 SGTC_1927 st060202 13.8 µM 0.222000718326462 0.456583680053589 no 1500 0.412156662070285 2038 688887 SGTC_300 r073-0011 5.04 µM 0.221566218186944 0.456728757839303 no 1501 0.412325791414356 2047 2735780 SGTC_2869 9037858 32.47 µM 0.220353471723274 0.457133719285133 no 1502 0.412797939488657 2033 27187042 SGTC_928 2764-0428 58.7 µM 0.219031749087038 0.457575120840412 no 1503 0.4133126579984 1938 662578 SGTC_3016 9080866 49.47 µM 0.218765778335832 0.457663950586971 no 1504 0.413416253040704 1922 17066299 SGTC_2140 5586273 200 µM 0.217646166410099 0.458037905231048 no 1505 0.413852405519067 1990 854421 SGTC_430 0958-0115 16.4 µM 0.216970617230081 0.458263559218278 no 1506 0.414115621769735 1880 6833180 SGTC_2135 5326629 150.42 µM 0.216678219674487 0.458361233076801 no 1507 0.414229561476132 1873 5020077 SGTC_1135 dihydrocapsaicin 536.708 nM 0.215423829263701 0.458780284022573 no 1508 0.414718446524442 1800 107982 A Capsaicinoid. SGTC_235 0330-0087 5 mM 0.214016404421578 0.459250513295841 no 1509 0.415267132335333 1920 46494818 YHR062C RPP1 SGTC_3114 9122766 49.47 µM 0.213680643746608 0.459362701445095 no 1510 0.415398053388766 1879 17176985 SGTC_2937 9044753 11.33 µM 0.213396701542257 0.459457577947505 no 1511 0.415508776522298 1931 6465530 YGL099W LSG1 SGTC_1845 st056753 3.01 µM 0.213247110340099 0.459507563309373 no 1512 0.415567112242539 1830 5375839 SGTC_373 0844-0104 25.9 µM 0.212993905323498 0.459592172312707 no 1513 0.415665858232176 2043 5375804 SGTC_500 h-89 112 µM 0.212597530800591 0.459724625389224 no 1514 0.415820448777871 2044 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3257 9139206 32.98 µM 0.206495231647489 0.461764333692913 no 1515 0.418202044539078 2025 4910041 SGTC_2218 6965428 192.983 µM 0.206328361015365 0.461820124982922 no 1516 0.418267213116093 2020 675684 SGTC_1926 methyl fluorone black 53.6 µM 0.206188724883586 0.461866811306212 no 1517 0.418321747432001 1978 72721 Reacts with homocysteine. SGTC_2273 7815444 169.05 µM 0.205620655858956 0.462056746455846 no 1518 0.418543620625171 2078 2824616 SGTC_171 k064-0041 9.68 µM 0.205174616616493 0.462205886741413 no 1519 0.418717850282751 1890 53325 SGTC_1782 st039423 80.636 µM 0.203368131991633 0.462809967614954 no 1520 0.41942365315368 1873 2068169 SGTC_1952 st077036 64.1 µM 0.202096626035866 0.463235205385968 no 1521 0.419920592740169 2086 2937007 SGTC_1289 0976-0073 69.1 µM 0.201679004810157 0.463374882280519 no 1522 0.420083838529971 1991 3391136 SGTC_1271 0832-2808 169 µM 0.201261443369966 0.463514543693453 no 1523 0.420247074697025 2059 3663794 SGTC_1273 0849-0096 14.1 µM 0.20013176696104 0.463892408072918 no 1524 0.420688764732567 1935 5286025 SGTC_1651 st011928 86.1 µM 0.199795555818215 0.464004873321072 no 1525 0.420820238598433 1992 720198 SGTC_2344 7990960 76.95 µM 0.199488995131875 0.464107422767621 no 1526 0.420940125483954 1926 140813 SGTC_2508 celastrol 40.54 µM 0.198913262386881 0.464300021006549 no 1527 0.421165297466551 2059 122724 Celastrol is a natural product and antioxidant. SGTC_3244 9134489 49.47 µM 0.197720019437173 0.46469921976451 no 1528 0.421632062836759 1918 16584271 SGTC_661 1304-0007 33.6 µM 0.197232381981396 0.464862368852079 no 1529 0.421822845567202 1930 3117130 SGTC_2364 9055074 200 µM 0.196726188474473 0.4650317324946 no 1530 0.422020907556322 1906 6470630 SGTC_2677 mitomycin C 100 µM 0.196346638203093 0.465158727645833 no 1531 0.422169429874188 1958 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_562 3772-2733 112 µM 0.195824719980316 0.465333364017226 no 1532 0.422373680454184 2047 2876874 YIL048W NEO1 SGTC_2338 7999974 200 µM 0.195179206630408 0.465549365150309 no 1533 0.422626328357476 2085 315925 SGTC_666 0272-0154 136 µM 0.194888098273375 0.465646778908047 no 1534 0.422740275873816 1977 6870312 SGTC_789 1309-1135 70.6 µM 0.191566360824844 0.466758478157893 no 1535 0.424040947305447 2050 3092424 SGTC_1384 3089-0840 101 µM 0.190539432094503 0.467102217425672 no 1536 0.424443223390402 2066 1069836 SGTC_1231 0242-0792 125 µM 0.189674807375891 0.46739164843273 no 1537 0.42478198161114 1918 3707635 SGTC_370 0180-0345 38.7 µM 0.189674242906316 0.467391837393186 no 1538 0.424782202787356 1939 3989527 SGTC_176 1486-1328 72.834 µM 0.188559538110968 0.467765007528497 no 1539 0.425219023878582 1928 22310231 SGTC_2815 7968870 71.43 µM 0.18853032084293 0.467774788986524 no 1540 0.425230474531791 1958 2977326 YHR190W ERG9 SGTC_797 k781-0471 270 µM 0.188208517970883 0.467882524550852 no 1541 0.425356597718674 2020 23738129 SGTC_1066 ketoconazole 628 nM 0.187174660342361 0.468228662994788 no 1542 0.425761845916313 2033 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1379 2144-0755 36.5 µM 0.186234906143393 0.468543316193082 no 1543 0.426130275809305 2086 5392327 SGTC_3227 9130768 49.47 µM 0.185905793795602 0.468653515890585 no 1544 0.426259319308424 2021 17720899 SGTC_2195 6536160 144.242 µM 0.185446962197389 0.468807154677587 no 1545 0.4264392383272 1933 3834386 SGTC_192 3455-0609 60.9 µM 0.18389577046784 0.469326602202194 no 1546 0.427047611451764 2009 3769639 SGTC_1176 0848-0131 83.3 µM 0.183760513409702 0.469371898216496 no 1547 0.427100667144883 2111 6769040 SGTC_1375 2910-0797 186 µM 0.183514632482562 0.469454241891686 no 1548 0.427197119337086 1981 742508 SGTC_2122 5258151 111.688 µM 0.181978107947275 0.469968841866941 no 1549 0.427799953177288 1980 2173356 SGTC_816 0325-0417 81.3 µM 0.180996452210934 0.470297636129526 no 1550 0.428185180375112 1953 68101 SGTC_496 calpeptin 138 µM 0.1793327150671 0.470854931818241 no 1551 0.42883823015506 1957 73364 A calpain inhibitor. SGTC_1881 5652484 16 µM 0.178549926274446 0.471117159409569 no 1552 0.429145557780495 2103 2255129 SGTC_82 0054-0107 293.755 µM 0.178175198100665 0.471242694601752 no 1553 0.429292693548521 2091 3104697 SGTC_423 5-fluorouracil 457 µM 0.177926612355562 0.471325973235491 no 1554 0.429390305333964 1845 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2205 7238770 200 µM 0.176348003844277 0.471854851497431 no 1555 0.430010275651645 2099 279867 SGTC_3255 9139072 49.47 µM 0.17603158149275 0.471960867888346 no 1556 0.430134565698022 1996 17646060 SGTC_3153 9100258 49.47 µM 0.175456261720969 0.472153632193576 no 1557 0.430360567845534 1937 25236848 SGTC_2729 fluphenazine 10.66 µM 0.175136084496758 0.472260912301443 no 1558 0.430486352550742 2051 3372 An atypical antipsychotic. SGTC_2030 5175110 200 µM 0.174718689813864 0.472400769575293 no 1559 0.430650340659938 2043 2831986 SGTC_1648 st011736 69.8 µM 0.17181674332822 0.473373223736203 no 1560 0.431790801001657 2091 2855514 SGTC_3263 9137018 49.47 µM 0.17133432856069 0.473534898442337 no 1561 0.431980444622801 1896 43844957 SGTC_273 hydroxyurea 18.1 mM 0.171309564960529 0.473543197741831 no 1562 0.431990179944673 1988 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2323 6148992 148.28 µM 0.17053256325399 0.473803608740837 no 1563 0.432295663816339 1976 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_945 3381-0768 11.3 µM 0.17003811404913 0.473969328512751 no 1564 0.432490081204677 2104 1126236 YIL048W NEO1 SGTC_1348 1493-0373 93.8 µM 0.169731467875051 0.474072106418806 no 1565 0.432610662671458 2035 3010129 SGTC_2710 st078562 53.7235 µM 0.168691682178315 0.474420621850474 no 1566 0.433019580838134 2081 17250908 SGTC_2075 5212009 200 µM 0.168293185217539 0.474554195288957 no 1567 0.433176317405593 2094 780898 SGTC_3210 9128157 49.47 µM 0.166741780919366 0.475074242438901 no 1568 0.433786614643853 1848 17590849 SGTC_3299 9121982 43.1275 µM 0.166648664516364 0.475105457403123 no 1569 0.433823250160626 1990 17594604 YPL160W CDC60 SGTC_2387 9077560 195.08 µM 0.166527100884186 0.475146208825184 no 1570 0.433871078749398 1970 5303272 SGTC_2283 7944793 200 µM 0.166251888650037 0.475238468380183 no 1571 0.433979363170295 1979 2970533 SGTC_306 1672-3436 11.6 µM 0.166155518917457 0.475270774774983 no 1572 0.43401728177215 2045 6797378 SGTC_2524 avocatin b 10.57 µM 0.166082363734645 0.475295298975859 no 1573 0.434046066549755 2107 6710748 SGTC_983 1491-0821 12.2 µM 0.165837226844838 0.475377478200513 no 1574 0.434142524476978 2102 46495113 SGTC_2760 etidronate 98.04 µM 0.165466039452476 0.475501916348631 no 1575 0.434288588971172 2009 3305 A chelator and antioxidant. SGTC_384 k007-0144 5.16 µM 0.165327436492305 0.475548382698835 no 1576 0.434343132379609 2021 6824886 SGTC_2240 6690706 185.951 µM 0.164147244974268 0.47594405282465 no 1577 0.434807615037396 1897 805876 SGTC_1978 st071761 42 µM 0.163552758602908 0.47614336888947 no 1578 0.435041618481174 1966 5147680 SGTC_1661 st013063 9.66 µM 0.161869285785014 0.476707826459373 no 1579 0.435704395098132 2037 721395 SGTC_50 0929-0078 56.389 µM 0.161778994162458 0.476738101988324 no 1580 0.435739947674417 2055 1377751 SGTC_977 1348-1378 135 µM 0.161617178112373 0.476792360586117 no 1581 0.435803664491168 2099 X977 SGTC_250 brefeldin a 552.239 µM 0.160212430424734 0.477263405009407 no 1582 0.436356868907761 2026 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1364 1653-0028 37.6 µM 0.158886160603104 0.477708163154583 no 1583 0.436879282210322 2036 5718652 SGTC_1728 st035614 33.7865 µM 0.156704457587684 0.478439846812993 no 1584 0.43773888692042 2003 15945546 SGTC_514 4466-0038 2.65 nM 0.156016152471256 0.478670700763886 no 1585 0.438010144649254 2020 5722064 SGTC_453 enantio-paf c16 10 µM 0.155456690774354 0.47885834657864 no 1586 0.438230647275109 2111 13871343 A lipid and platelet activating factor SGTC_2675 theaflavin digallate 100 µM 0.155273236343099 0.478919878991588 no 1587 0.438302957000542 2084 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2683 piperine 63.03 µM 0.155237801747972 0.478931764159771 no 1588 0.438316924007955 2038 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2686 alizarin 95.37 µM 0.155226005265483 0.478935720838975 no 1589 0.438321573762293 1990 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1596 piperlongumine 63 µM 0.154729897694305 0.479102123037696 no 1590 0.438517129443777 2146 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3347 9188721 44.724 µM 0.154066970697342 0.479324484748157 no 1591 0.438778465430431 2053 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_549 1661-1316 519 µM 0.153928429616366 0.479370955584782 no 1592 0.43883308382459 2147 2857282 SGTC_2773 thioridazine 9.09 µM 0.153913297305307 0.479376031433079 no 1593 0.438839049652936 2169 5452 An antipsychotic. SGTC_2081 5214970 32.255 µM 0.152954756528116 0.47969756263656 no 1594 0.439216977211559 2136 2063512 SGTC_535 2293-4129 48.2 µM 0.152258904041743 0.479930986438183 no 1595 0.439491368382035 2131 396118 YIL048W NEO1 SGTC_2968 9090663 33.37 µM 0.149460441763922 0.480869799634477 no 1596 0.440595160804769 1998 25236811 SGTC_516 3992-2719 87.3 µM 0.148988435560026 0.481028156358137 no 1597 0.440781379100874 2029 5350887 YDR037W KRS1 SGTC_967 1306-0166 352 µM 0.147529552491535 0.481517626247979 no 1598 0.441357027707016 2153 4437607 SGTC_632 0781-2353 4.65 µM 0.147473955396428 0.481536280186397 no 1599 0.441378967763659 2083 6811515 YHR007C ERG11 SGTC_3307 9126885 69.2785 µM 0.147415439403299 0.481555913517201 no 1600 0.441402059887519 1986 24824909 SGTC_263 alizarin 107.927 µM 0.146232901869486 0.481952688937182 no 1601 0.441868766397664 2129 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1254 0550-0035 264 µM 0.146118698753692 0.481991008326399 no 1602 0.44191384268662 2088 15121435 SGTC_449 xestospongin c 11.1929 µM 0.145691659938961 0.482134297189193 no 1603 0.442082402760667 2084 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2219 9098279 200 µM 0.144005912824145 0.482699956157743 no 1604 0.44274790027415 2149 902349 SGTC_2656 pseudo-anisatin 100 µM 0.142915064803994 0.48306601306366 no 1605 0.443178630356635 2079 6708809 A neurotoxin. SGTC_2301 7769476 200 µM 0.142616201260236 0.48316630549107 no 1606 0.443296650762903 2083 977820 SGTC_163 TUB2.036 7.546 µM 0.142590811390635 0.483174825855647 no 1607 0.443306677385816 2167 15992207 YJR013W GPI14 SGTC_790 1575-0012 79.1 µM 0.142405157177286 0.483237128164803 no 1608 0.443379994532267 2176 378741 YLR208W SEC13 SGTC_2428 5615643 7.78 µM 0.141789218582471 0.483443829315091 no 1609 0.44362325017565 2108 2253075 SGTC_1423 4048-0112 5.59 µM 0.141553531367798 0.483522924123688 no 1610 0.443716336905694 2162 X1423 SGTC_2452 5863136 48.41 µM 0.140969736205289 0.483718844056139 no 1611 0.443946925282047 2123 2184096 SGTC_2147 5545932 89.7195 µM 0.140635029045397 0.483831172566556 no 1612 0.44407913703241 2045 797404 SGTC_3154 9100113 49.47 µM 0.140318990995585 0.483937236857757 no 1613 0.444203980061974 2035 25237525 SGTC_2774 tamoxifen 10.92 µM 0.139225527867626 0.484304218454398 no 1614 0.444635968315065 2136 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1243 0416-0003 5.65 µM 0.13890285814969 0.484412513502093 no 1615 0.444763456193966 2031 2141977 SGTC_1575 cyproterone acetate 48 µM 0.138825091844388 0.484438613755242 no 1616 0.444794182774896 2024 9880 An androgen receptor antagonist and liver toxin. SGTC_1849 st056239 19.2 µM 0.138658669593864 0.484494469311983 no 1617 0.44485993970376 1949 5393181 SGTC_254 nsc-64875 3.808 µM 0.137408058061405 0.484914216133564 no 1618 0.445354131026268 2157 56993 SGTC_1792 st045773 43.6 µM 0.136666748103826 0.485163032330024 no 1619 0.445647107014306 2046 2919270 SGTC_1719 st032227 49.2 µM 0.136174422259768 0.485328281715391 no 1620 0.445841697436534 2054 3125804 SGTC_853 0419-0306 21 µM 0.136067447185369 0.485364188280204 no 1621 0.445883980764468 2006 762713 SGTC_2093 5331342 194.4 µM 0.135847049856063 0.485438165802711 no 1622 0.445971097694342 2156 33839 SGTC_1603 st002045 67.8 µM 0.13555758089284 0.485535328343319 no 1623 0.446085520680559 2193 5887985 SGTC_2123 5259487 200 µM 0.135372593925648 0.485597421128003 no 1624 0.446158645763912 2139 2173474 SGTC_2820 7989630 71.43 µM 0.132293241064327 0.486631087832946 no 1625 0.447376176619214 2183 2984098 SGTC_1666 st014829 29 µM 0.132153230824654 0.486678088181851 no 1626 0.447431546486523 2121 3858230 SGTC_1206 3978-0017 132 µM 0.13113778195495 0.487018971969582 no 1627 0.447833156774202 2081 3873677 SGTC_1925 st057770 10.1 µM 0.130569354362161 0.487209795926842 no 1628 0.448057993407696 1931 5989122 SGTC_3261 9137475 49.47 µM 0.129764239710959 0.48748008190237 no 1629 0.448376478106953 2186 17027690 SGTC_1912 st060209 90.8 µM 0.129096994093601 0.487704088067535 no 1630 0.448640450236139 2045 688787 SGTC_2698 st077697 67.5 µM 0.128962032805642 0.487749397434907 no 1631 0.448693845664967 2044 3154499 SGTC_2398 5228213 48.84 µM 0.12707850381685 0.488381754311369 no 1632 0.449439132490334 2199 80771 YMR134W ERG29 SGTC_270 tamoxifen 5.46 µM 0.12608209908146 0.488716289022418 no 1633 0.449833468623562 2201 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3256 9138902 49.47 µM 0.125311104265283 0.48897514966356 no 1634 0.450138630773543 2184 17228773 SGTC_164 4100-3994 89.624 µM 0.124980928099945 0.489086007365843 no 1635 0.450269324555689 2192 4615967 SGTC_3039 9090270 49.47 µM 0.124251087895678 0.489331056525507 no 1636 0.450558236653533 2220 17173750 SGTC_843 0310-0051 143 µM 0.123955069612628 0.489430447971403 no 1637 0.450675424936282 2066 2065037 SGTC_2792 7535235 81.82 µM 0.12375393401446 0.489497981870619 no 1638 0.450755053334812 2045 1281891 SGTC_2055 5235184 200 µM 0.12360150562644 0.489549161889706 no 1639 0.450815400156148 2116 2836034 SGTC_195 4234-0266 16.654 µM 0.123296983164072 0.489651410191724 no 1640 0.450935964846405 2066 2303354 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.122423575755989 0.48994467448994 no 1641 0.451281784094519 2103 5379071 SGTC_2669 eugenol 100 µM 0.12238268280379 0.48995840526466 no 1642 0.451297976266817 2186 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2286 7945697 125 µM 0.120406149755989 0.490622086809679 no 1643 0.45208071002259 2078 1245733 SGTC_2706 st078239 82.5 µM 0.120152593967575 0.490707227853973 no 1644 0.452181135082014 2213 15434492 SGTC_631 k072-0230 41.5 µM 0.118219573452987 0.491356326989064 no 1645 0.452946840668503 2131 5773147 SGTC_1013 4112-3890 241 µM 0.117835962213232 0.491485144603461 no 1646 0.453098817156866 2051 705171 SGTC_350 k064-0020 19.8 µM 0.117599967871133 0.491564392536242 no 1647 0.453192315202656 2209 2790705 SGTC_1349 flufenamic acid 69 µM 0.117260770599533 0.491678297046788 no 1648 0.453326705519273 2157 3371 A non-steroidal anti-inflammatory. SGTC_2705 st078069 42.8 µM 0.117006957157563 0.491763529591466 no 1649 0.453427270169834 2117 1530061 SGTC_2124 5246320 200 µM 0.11556619189721 0.492247356878178 no 1650 0.453998179142743 2119 579342 SGTC_2960 9079389 5.97 µM 0.113929852031953 0.492796874397351 no 1651 0.454646700566849 2204 16457355 SGTC_2274 7947094 46.08 µM 0.113472814396561 0.492950359784155 no 1652 0.45482785741172 2232 2971028 SGTC_931 2812-0076 566 µM 0.113145068216007 0.493060426307538 no 1653 0.454957772552402 2161 3450959 SGTC_2121 5257820 149.641 µM 0.112753276592719 0.493192001811429 no 1654 0.455113080954011 2220 791256 SGTC_2324 6149169 200 µM 0.111526486885433 0.493603999709055 no 1655 0.455599431557737 2183 2888231 SGTC_1067 clotrimazole 1.36 µM 0.109432874457131 0.494307121809946 no 1656 0.456429580135397 2107 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2558 carylophyllene oxide 100 µM 0.108944895808769 0.494471007950917 no 1657 0.456623098420026 2237 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3103 9120822 49.47 µM 0.10874924251725 0.494536717775871 no 1658 0.456700691775253 2212 17141819 SGTC_1461 k072-0203 53.8 µM 0.107854276137947 0.494837292573887 no 1659 0.457055643910758 2211 5418714 SGTC_735 3076-0345 636 µM 0.10657770024931 0.495266036100506 no 1660 0.457562005213277 2208 2888990 SGTC_1696 st025591 34.7925 µM 0.106108182289072 0.49542372713732 no 1661 0.457748259635233 2220 2787147 SGTC_78 0336-0123 156.75 µM 0.105918270175851 0.495487510712369 no 1662 0.457823599052414 2009 6765896 SGTC_2390 9097792 176.6 µM 0.105399463922531 0.495661756724353 no 1663 0.458029420711949 2048 4497149 SGTC_346 4513-0042 7.16 µM 0.103798613568981 0.496199422604843 no 1664 0.45866458336952 2188 2827372 SGTC_102 gallobenzophenone 83.616 µM 0.103428795200894 0.496323631808107 no 1665 0.458811329714115 2225 70837 SGTC_2611 pyromycin 23.93 µM 0.103247079712913 0.496384663888985 no 1666 0.458883437664844 2129 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.102351722356319 0.496685385323277 no 1667 0.459238751163653 2205 5357218 A potent inhibitor of glutathione S-transferases. SGTC_433 pimozide 108 µM 0.101898623203436 0.496837567330124 no 1668 0.459418571400006 2174 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2992 9074591 71.4286 µM 0.101784436245007 0.4968759192751 no 1669 0.459463889780879 2259 17741321 SGTC_1610 st001799 48.1 µM 0.101709264268661 0.496901167283651 no 1670 0.459493724230767 2058 621897 SGTC_3284 9108171 64.8615 µM 0.101534372798677 0.496959908122216 no 1671 0.459563136495596 2127 8687505 SGTC_1932 st074806 40.9 µM 0.0996636067727693 0.497588246606829 no 1672 0.460305697114946 2160 17251235 SGTC_1188 1403-0014 4.57 µM 0.0975738038239451 0.498290160528923 no 1673 0.461135363371785 2129 9614867 SGTC_404 fumagillin 50 µM 0.097020019886975 0.498476164044652 no 1674 0.461355247939141 2115 12015870 A methionine aminopeptidase binder. SGTC_3087 9117406 49.47 µM 0.0945783423697524 0.49929627177302 no 1675 0.462324876497114 2120 42546093 SGTC_2235 salicylic acid 500 µM 0.0943682075450909 0.499366851795288 no 1676 0.462408334889429 2247 338 A COX inhibitor and kinase inhibitor. SGTC_2588 indole-3-carbinol 100 µM 0.0937451717374187 0.499576116984628 no 1677 0.462655793197026 2235 3712 Induces cell cycle arrest. SGTC_2866 9034245 58.44 µM 0.0935582112778611 0.499638913265827 no 1678 0.462730053259793 2256 6462273 SGTC_1615 st002656 86.5 µM 0.0914081184077259 0.499638913265827 no 1679 0.463584155600526 2252 1584458 SGTC_77 0828-0286 12.516 µM 0.091028771335198 0.499511498177941 no 1680 0.463734864868492 2240 745345 SGTC_1907 st060210 83.7 µM 0.0910049829414179 0.499503508134192 no 1681 0.463744315837117 2210 688793 SGTC_10 0279-0212 42.575 µM 0.0895240531916925 0.499006094092446 no 1682 0.464332719323169 2248 39851 YBR002C RER2 SGTC_1325 1431-0015 227 µM 0.0886958665329917 0.498727923741002 no 1683 0.46466180880932 2064 1103340 SGTC_1330 1469-0054 61.8 µM 0.0885624030336806 0.498683096233669 no 1684 0.464714844332163 2265 7102664 SGTC_1178 0988-0033 191 µM 0.0829369612223856 0.496793653988561 no 1685 0.466950832230686 2200 5392207 SGTC_13 0199-0087 65 µM 0.0829206097946265 0.496788162045851 no 1686 0.466957333114202 2265 4589825 SGTC_2272 7805186 180 µM 0.0827180027818676 0.496720112619701 no 1687 0.467037884889685 2272 2956062 YPR165W RHO1 SGTC_3167 9103034 49.47 µM 0.0823928702430115 0.496610910861034 no 1688 0.467167152748105 2242 5127859 SGTC_1711 st032263 62.8 µM 0.0823289170785896 0.496589431041088 no 1689 0.467192579982446 2174 3958979 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0823124603439582 0.496583903752519 no 1690 0.467199123061856 2173 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_554 4483-2211 187 µM 0.0819786191425655 0.496471777359077 no 1691 0.467331857835268 2177 747107 SGTC_2217 6934799 96.0675 µM 0.0816912917625924 0.496375273667132 no 1692 0.467446101690619 2259 675606 SGTC_1040 k898-0338 155 µM 0.0812877279607871 0.496239730394061 no 1693 0.467606566680327 2277 20969351 SGTC_2103 5378138 10 µM 0.081021971487749 0.496150472123716 no 1694 0.467712239613043 2254 244142 SGTC_727 3032-0951 202 µM 0.0809111542683646 0.496113252566461 no 1695 0.467756304614339 2184 3652836 SGTC_456 gingerol 170 µM 0.0803154968124321 0.495913193029018 no 1696 0.46799316667791 2211 442793 A herb. SGTC_831 k061-1017 217 µM 0.0801345464395022 0.495852418623049 no 1697 0.468065123500246 2238 1240153 SGTC_1853 st056710 91.2 µM 0.0798250245890071 0.495748462130591 no 1698 0.468188210542876 2290 269167 SGTC_1981 st071826 47 µM 0.0795372336550238 0.495651804476584 no 1699 0.468302658616545 2164 11838600 SGTC_519 k048-0011 62.8 µM 0.0791602476585268 0.495525190096796 no 1700 0.468452581551001 2158 6836379 SGTC_200 k038-0079 37.545 µM 0.0754362507498856 0.494274476096122 no 1701 0.469933808719395 2222 3436683 SGTC_1414 3917-0015 5.4 µM 0.0739134075013564 0.493763040764557 no 1702 0.470539643694347 2268 6618702 SGTC_2777 climbazole 1.536 µM 0.0737915770360996 0.49372212536045 no 1703 0.470588114652621 2292 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3218 9131285 49.47 µM 0.0731290094560158 0.493499610589598 no 1704 0.470851728623519 2261 17156417 SGTC_3089 9117425 49.47 µM 0.0730485998875622 0.493472606210024 no 1705 0.470883721832456 2121 9401657 SGTC_2872 9044037 25.97 µM 0.0729832176001782 0.493450648545441 no 1706 0.470909736153397 2190 6465195 SGTC_1819 st053448 58.6 µM 0.0728945092861572 0.49342085721498 no 1707 0.470945031638127 2213 2857616 SGTC_214 4373-3496 70 µM 0.0724111971408069 0.493258544872195 no 1708 0.471137337079247 2215 3779166 SGTC_1006 4099-6547 255 µM 0.0703582222323191 0.492569100170038 no 1709 0.471954271316578 2246 3146833 SGTC_1248 0469-0687 58.6 µM 0.0703155216414727 0.492554760381042 no 1710 0.471971264301143 2218 4017482 SGTC_891 0929-0073 133 µM 0.070231141232597 0.492526423629118 no 1711 0.472004844196932 2254 5603632 SGTC_2471 5466956 24.79 µM 0.0692267073705246 0.492189116121621 no 1712 0.472404582345421 2196 724419 SGTC_2384 9036245 200 µM 0.0687561853396453 0.492031108009075 no 1713 0.472591847271284 2234 6462766 SGTC_2125 5246583 200 µM 0.068402670779104 0.491912393520983 no 1714 0.472732547918879 2281 835267 SGTC_1467 k284-1082 293 µM 0.0680419910510668 0.491791273620865 no 1715 0.472876103847074 2303 3334705 SGTC_794 k038-0031 316 µM 0.0660445289399501 0.491120519651884 no 1716 0.473671186926209 2278 6624242 SGTC_1707 st032323 6.317 µM 0.0659852149722703 0.491100602212155 no 1717 0.473694798270951 2224 3132057 YMR211W DML1 SGTC_1131 3454-3128 32.3 µM 0.0658613796272013 0.491059018772835 no 1718 0.473744094192305 2204 710982 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0642069856195384 0.490503489037558 no 1719 0.474402707577225 2286 1377 SGTC_545 4218-0007 221 µM 0.0640613734579876 0.49045459472826 no 1720 0.474460679078289 2229 2840508 SGTC_828 2074-0507 139 µM 0.0639792467806088 0.490427017924801 no 1721 0.474493375808121 2280 X828 SGTC_1112 tnp00069 1.16933 µM 0.0636954280920058 0.490331716575226 no 1722 0.47460637260527 2277 145826 SGTC_407 eburnamonine 100 µM 0.0636159600117137 0.490305032683013 no 1723 0.474638011616068 2264 3195 SGTC_1744 st037937 38.9 µM 0.0623005409012273 0.489863345988709 no 1724 0.475161748869263 2246 1016152 SGTC_2026 5148700 152 µM 0.0610598607124907 0.489446766242024 no 1725 0.475655767992195 2290 79838 SGTC_1119 parthenolide 318.541 nM 0.0608313823163865 0.489370051926255 no 1726 0.475746748559673 2240 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3226 9131256 49.47 µM 0.0601721561461397 0.489148711180013 no 1727 0.476009260848241 2294 17178073 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0594985917065361 0.48892255969113 no 1728 0.476277493573614 2277 688751 SGTC_686 1319-0111 510 µM 0.0586254921954944 0.488629418952956 no 1729 0.476625202881849 2282 4562600 SGTC_1738 st035555 74 µM 0.0569790750853371 0.488076655816269 no 1730 0.477280931859481 2267 5331140 SGTC_3065 9113888 49.47 µM 0.056289530274211 0.487845156855677 no 1731 0.477555579621372 2278 16648368 SGTC_3082 9117008 49.47 µM 0.0562568831853893 0.487834196440321 no 1732 0.47756858331989 2196 41448529 SGTC_479 n-linoleoylglycine 10 µM 0.0556569208084722 0.48763277624033 no 1733 0.477807559244382 2272 6433346 An anti-infammatory. SGTC_1153 4055-0057 267 µM 0.0540591200231244 0.487096375873958 no 1734 0.478444031044943 2263 882706 SGTC_2012 4023501 200 µM 0.0523784217331598 0.486532171057042 no 1735 0.479113583736895 2245 3477460 SGTC_788 1182-0090 188 µM 0.0518285584145451 0.486347589570049 no 1736 0.479332649900942 2293 5715185 SGTC_1245 0418-0076 17.2 µM 0.0517160823944554 0.486309833289688 no 1737 0.479377461245041 2257 6790114 SGTC_1483 3453-0561 55.9 µM 0.0507940499795793 0.486000327400899 no 1738 0.479744816093566 2302 4546991 SGTC_2844 9010103 25.97 µM 0.0500345873625678 0.485745398923159 no 1739 0.480047413049427 2238 2480525 SGTC_68 0986-0284 82.829 µM 0.0494286097015636 0.485541994845557 no 1740 0.480288864388422 2060 423278 YIL048W NEO1 SGTC_2106 5357045 167.29 µM 0.0493547135084293 0.485517190908587 no 1741 0.48031830876699 2297 668842 SGTC_532 1548-0774 215 µM 0.0492144513347379 0.485470110773962 no 1742 0.480374197361276 2328 5932993 SGTC_2275 7947463 200 µM 0.0487100039850886 0.485300790614126 no 1743 0.480575201656931 2328 1225414 SGTC_2328 6201408 200 µM 0.0475992036581044 0.484927954570469 no 1744 0.481017833350329 2275 2890418 SGTC_803 4488-1585 147 µM 0.0472295557040654 0.484803886500293 no 1745 0.481165135876998 2310 747204 SGTC_2598 perillyl alcohol 100 µM 0.0455177539185566 0.484229359354389 no 1746 0.481847311991927 2285 10819 An apoptosis inducer. SGTC_1991 st073000 8.92 µM 0.0451768181077351 0.484114935913364 no 1747 0.481983185925292 2296 4301969 YIL048W NEO1 SGTC_2263 7948595 193.29 µM 0.0450648685471481 0.484077364158131 no 1748 0.482027801898517 2336 2971371 SGTC_1476 4112-3294 3.34 µM 0.0430743188013217 0.483409333216524 no 1749 0.482821145460547 2298 704369 SGTC_441 propafenone 146 µM 0.0424019954863161 0.483183711113221 no 1750 0.483089118806803 2329 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_730 1436-0052 41.2 µM 0.042263980161962 0.483137395805122 no 1751 0.483144129640938 2333 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_29 0299-0004 12.984 µM 0.0409403935069099 0.482693237037007 no 1752 0.483671707532742 2326 16871 A napthoquinone isolated from Swertia calycina. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0408072126078493 0.482648546421714 no 1753 0.483724794660277 2319 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2491 paeonol 100 µM 0.0403721957241286 0.482502572264567 no 1754 0.483898198384259 2274 11092 Increases levels of cortical cytochrome oxidase. SGTC_2063 5246145 200 µM 0.0401198216050061 0.482417886741898 no 1755 0.483998799583634 2307 711240 SGTC_2444 5485484 36.41 µM 0.0395623297317645 0.482230820097058 no 1756 0.484221030215368 2310 6790631 SGTC_1261 0712-0010 12.7 µM 0.0384003879494182 0.481840942639288 no 1757 0.484684225836345 2315 2840123 SGTC_3018 9082602 49.47 µM 0.0379461319058185 0.481688526458392 no 1758 0.484865315786694 2299 17332089 SGTC_3062 9077494 49.47 µM 0.0377719460659038 0.481630082726225 no 1759 0.484934756100322 2291 16459633 SGTC_733 4069-0007 56.1 µM 0.0367341615352027 0.481281888129433 no 1760 0.48534848502495 2343 5717425 YNL287W SEC21 SGTC_45 0kpi-0036 14.9 µM 0.0364658561632562 0.481191869365181 no 1761 0.485455451713376 2310 2795021 SGTC_2626 ethyl orsellinate 100 µM 0.0355031540619535 0.480868882441177 no 1762 0.485839265692337 2325 75653 A natural product. SGTC_396 dithiazanine 1.25 µM 0.0348283159127781 0.480642481458038 no 1763 0.486108320745297 2307 10578 An antihelmenthic. SGTC_481 bay k-8644 50 µM 0.032491603447744 0.479858588116103 no 1764 0.487040005986992 2328 2303 A calcium channel antagonist. SGTC_1234 0326-0494 15.5 µM 0.0324661276350713 0.479850042208075 no 1765 0.487050164006652 2326 1547813 SGTC_2687 chenodiol 100 µM 0.0309904040416753 0.479355023960014 no 1766 0.487638596232008 2320 5702181 A cholesterol synthesis inhibitor. SGTC_2356 9061756 188.97 µM 0.0302420558373417 0.479104009384105 no 1767 0.487937004074617 2336 20104043 SGTC_3241 9133421 49.47 µM 0.0295103423093234 0.478858582504287 no 1768 0.48822878528242 2355 17018221 SGTC_998 3996-0085 177 µM 0.0294692202236012 0.478844789822645 no 1769 0.488245183489194 2324 715391 SGTC_2021 4019055 173 µM 0.0287825748040044 0.478614487126398 no 1770 0.488518999207316 2336 44827708 YER133W GLC7 SGTC_616 4092-0450 108 µM 0.0284953627780191 0.478518157564112 no 1771 0.488633533248027 2324 787165 SGTC_3222 9128301 49.47 µM 0.0279190110601322 0.478324855700896 no 1772 0.48886337285989 2348 4911358 SGTC_2978 9011784 42.97 µM 0.0277275383178633 0.478260639029579 no 1773 0.488939729871185 2349 2994934 SGTC_971 1315-0384 26.7 µM 0.026342408082256 0.47779610703515 no 1774 0.4894921149387 2330 6769120 SGTC_610 4215-0184 155 µM 0.0252612667474408 0.477433544918196 no 1775 0.489923284361118 2329 5605015 SGTC_3042 9091578 49.47 µM 0.0243672781275135 0.477133758795704 no 1776 0.490279824421601 2351 25236497 SGTC_2665 lovastatin 100 µM 0.0239096607121328 0.476980308426556 no 1777 0.490462334176419 2363 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1675 st018485 24.5 µM 0.0217000212651763 0.476239410438317 no 1778 0.491343623405236 2274 3323024 SGTC_2712 st079126 47.7 µM 0.0214486533556427 0.4761551312647 no 1779 0.491443881356672 2362 3152970 SGTC_2761 levamisole 97.89 µM 0.0193041712570424 0.475436168444752 no 1780 0.492299228183848 2372 26879 An alkaline phosphatase inhibitor. SGTC_1469 k284-2957 126 µM 0.0185296982545454 0.475176536805024 no 1781 0.492608142924275 2330 23884841 SGTC_2804 7954240 19.48 µM 0.0178019466062835 0.474932577473711 no 1782 0.492898425919768 2359 828705 SGTC_275 trichlorophene 5.69 µM 0.0174289158091548 0.474807532485129 no 1783 0.493047220588234 2321 62616 SGTC_1847 st056231 15 µM 0.0167210735155073 0.474570260968782 no 1784 0.493329567638222 2364 5393180 SGTC_707 0865-0008 204 µM 0.0161853137616041 0.474390678187805 no 1785 0.493543275925452 2353 723043 SGTC_2863 9028737 58.44 µM 0.0137782515362344 0.473583913128201 no 1786 0.49450344682388 2386 6460917 SGTC_1763 st044482 94.5 µM 0.0127969139139942 0.473255033167817 no 1787 0.494894909317228 2374 88505 SGTC_2798 7813637 45.45 µM 0.0126762802618148 0.473214605939142 no 1788 0.49494303127814 2376 956368 SGTC_2883 9059145 45.46 µM 0.0122230669780991 0.473062725772003 no 1789 0.495123823206098 2379 16476510 SGTC_3036 9090181 49.47 µM 0.0121705188202717 0.473045116163788 no 1790 0.495144785328771 2380 25236586 SGTC_2922 7999257 32.47 µM 0.0118651069855941 0.47294276951418 no 1791 0.495266618223738 2383 2988377 SGTC_1969 st069479 40.1 µM 0.0106091878734833 0.472521916940647 no 1792 0.495767625792414 2392 3895485 SGTC_1377 2944-0135 198 µM 0.0104838664982296 0.472479924014013 no 1793 0.495817619007177 2380 1894137 SGTC_1399 3562-5772 25 µM 0.0103129131900922 0.472422641145164 no 1794 0.495885815822643 2392 23847490 SGTC_20 0481-0013 4.944 µM 0.00979331819009335 0.472248539262306 no 1795 0.496093093759945 2387 182045 SGTC_1591 genipin 88.4 µM 0.0086359449345116 0.471860754671134 no 1796 0.496554799258042 2383 442424 A DNA cross-linking agent. SGTC_2467 5474540 200 µM 0.00785957364119569 0.471600641912364 no 1797 0.496864516049953 2388 5413519 SGTC_1177 0983-0204 23.6 µM 0.00762044367606022 0.471520527069065 no 1798 0.496959912245802 2392 766818 SGTC_1767 st044992 70.3 µM 0.00759900166091794 0.471513343484897 no 1799 0.496968466124547 2382 9600693 SGTC_1975 st070967 30.8 µM 0.00758139523216946 0.471507444920168 no 1800 0.496975489871055 2394 261391 SGTC_2765 myclobutanil 7.74 µM 0.00740088131235173 0.471446968902917 no 1801 0.497047502485174 2379 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_833 3852-0053 558 µM 0.00702726842094379 0.471321802700449 no 1802 0.497196548584749 2379 3123681 SGTC_2254 7938975 95.19 µM 0.00601223275998808 0.470981764106255 no 1803 0.497601480602292 2395 2969277 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.00566701861121797 0.47086612161454 no 1804 0.497739198773146 2398 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2843 9000894 45.46 µM 0.00498615280058799 0.470638047156671 no 1805 0.498010821073708 2394 2242070 SGTC_2594 a-mangostin 100 µM 0.00490757403486875 0.470611725687729 no 1806 0.498042169082119 2395 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3014 9081533 49.47 µM 0.0046372119518309 0.470521163689501 no 1807 0.498150026719457 2396 21367265 SGTC_380 3970-0968 6 µM 0.00330002181505625 0.470073273496899 no 1808 0.498683484161235 2397 2891601 SGTC_229 benomyl 22.8748 µM 0.00145637210170145 0.469455807492798 no 1809 0.499418991798023 2403 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.000571846534298115 0.469159592564698 no 1810 0.499771866252001 2404 279621 SGTC_744 1594-0068 283 µM 0.000416909760449727 0.469107708213217 no 1811 0.499833677074263 2404 668392 SGTC_2970 9090938 41.86 µM -1.8880729201971e-05 0.468961775971928 no 1812 0.499992467678837 2406 17217104 SGTC_898 1000-0849 28.3 µM -0.000537976355091515 0.468787952958873 no 1813 0.49978537849645 2396 6751807 SGTC_508 roscovitine 141 µM -0.00166171766608485 0.468411680286455 no 1814 0.49933707087 2408 160355 A CDKinase inhibitor. SGTC_1093 fluphenazine 7.97 µM -0.0024904266606995 0.468134214064788 no 1815 0.49900646453583 2407 6602611 An atypical antipsychotic. SGTC_1352 1496-0991 99 µM -0.00425282996192445 0.467544182340556 no 1816 0.498303371431195 2413 3000039 SGTC_1168 k815-0004 80.5 µM -0.00435821776821845 0.467508901999304 no 1817 0.498261328169136 2415 642433 SGTC_1443 4112-3303 14 µM -0.00462929121696347 0.467418156774871 no 1818 0.49815318660157 2416 704433 SGTC_1088 bifonazole 369 nM -0.00511914255424401 0.467254177216195 no 1819 0.49795776651538 2413 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_683 panaxydol 45 µM -0.00555013025313328 0.467109907074312 no 1820 0.497785829747826 2428 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2726 cimetidine 79.27 µM -0.00605196715123539 0.466941926100391 no 1821 0.497585629162028 2418 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1701 st028638 40.4 µM -0.00715354282740585 0.46657321392862 no 1822 0.497146173651399 2425 3490878 SGTC_950 1165-0508 94.1 µM -0.00732424370629732 0.466516080611106 no 1823 0.497078075637835 2421 6148369 SGTC_2034 5197015 53.07 µM -0.00804048350214295 0.466276363805048 no 1824 0.496792345738303 2437 780676 SGTC_1913 st060213 96.1 µM -0.00824368838666136 0.466208355809356 no 1825 0.49671128140549 2420 688959 SGTC_1041 0206-0046 107 µM -0.00997799930688107 0.465627962229435 no 1826 0.496019420254177 2461 50494 SGTC_1181 1222-0449 220 µM -0.010145059908848 0.465572058620025 no 1827 0.495952776090166 2419 658318 SGTC_2349 9023730 187.07 µM -0.0103602596367774 0.465500047181686 no 1828 0.495866928332279 2428 4126287 SGTC_2757 clomiphene 4.22 µM -0.0108828156185316 0.465325191036106 no 1829 0.495658470418789 2426 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1692 fluoroquinolonic acid 71 µM -0.0109918476377028 0.465288707905597 no 1830 0.495614975538066 2472 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_336 4111-0029 111 µM -0.0112210963275219 0.465212000107889 no 1831 0.495523524183777 2438 3131175 SGTC_2560 caryophyllene 100 µM -0.0113374768428381 0.465173059079845 no 1832 0.495477098028944 2428 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_292 k038-0015 474 µM -0.0125812878443806 0.464756899673024 no 1833 0.494980924747895 2431 46368540 SGTC_715 0868-0130 184 µM -0.0127195852964134 0.464710629915046 no 1834 0.494925756461616 2440 2876258 SGTC_2406 ethylparaben 405.7 µM -0.0140750543557277 0.464257160108354 no 1835 0.494385051112756 2441 8434 A possible steroid mimic. SGTC_368 fentichlor 4.58 µM -0.0146251092756414 0.464073153404655 no 1836 0.494165633544353 2441 7329 A pesticide. SGTC_2836 9010338 19.48 µM -0.0148746954191682 0.463989663321886 no 1837 0.494066073910023 2439 2994051 SGTC_3253 9135987 49.47 µM -0.020511073228661 0.462104644766364 no 1838 0.491817839388153 2443 4182430 SGTC_2980 9014342 25.29 µM -0.0214381520281771 0.461794674803537 no 1839 0.49144806981712 2532 2996599 SGTC_1852 st056254 31.4 µM -0.0227445696481422 0.461357911861458 no 1840 0.490927011790725 2484 442583 SGTC_1563 conessine 56.1 µM -0.0229166061720191 0.461300399887223 no 1841 0.490858397032225 2458 441082 An anti-amoebic, histamine inhibitor. SGTC_2964 9083345 53.42 µM -0.0240979497660977 0.46090549751881 no 1842 0.490387239349252 2468 17741579 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0243342475704822 0.460826511936587 no 1843 0.490292997801125 2459 390807 SGTC_2445 5742597 35.57 µM -0.0260812424016825 0.460242604585432 no 1844 0.489596269184332 2466 1774255 SGTC_1043 0916-0009 19.3 µM -0.0278255177331981 0.459659691711186 no 1845 0.488900656815848 2444 3101130 SGTC_2905 7799065 20.05 µM -0.0280768922362789 0.459575692921189 no 1846 0.488800412065368 2461 1296806 SGTC_731 3966-0296 387 µM -0.0289768066453063 0.459274994181402 no 1847 0.488441544220622 2469 660956 SGTC_444 curcumin 90.4 µM -0.0290205593229112 0.459260375189085 no 1848 0.488424096765177 2471 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_527 4476-4215 268 µM -0.02924771603745 0.45918447666845 no 1849 0.488333512799567 2489 4418754 SGTC_3021 9087658 49.47 µM -0.0293219302896989 0.459159680224465 no 1850 0.488303918289404 2464 25237042 SGTC_2104 5389443 200 µM -0.0302372450052927 0.458853868636711 no 1851 0.487938922441612 2488 2244536 SGTC_2404 5161160 200 µM -0.0314516378793967 0.458448171033921 no 1852 0.487454680212733 2461 2831543 SGTC_3101 9120531 49.47 µM -0.0315108012861914 0.45842840715495 no 1853 0.487431089121388 2457 24824904 SGTC_2414 st077232 92.9 µM -0.0325746898844036 0.458073026589055 no 1854 0.487006876831173 2476 729801 SGTC_180 1486-1293 102.781 µM -0.0338616647449168 0.457643171270673 no 1855 0.486493731373495 2473 4140536 SGTC_1922 5578187 25 µM -0.0351550204359856 0.457211234638417 no 1856 0.485978064266898 2468 1350412 SGTC_2229 7354935 190 µM -0.0363837057324517 0.456800942514859 no 1857 0.485488203259562 2462 318112 SGTC_1053 3366-3204 134 µM -0.0368932998283923 0.456630788386507 no 1858 0.485285041037258 2493 3632071 YPR165W RHO1 SGTC_3139 9095020 49.47 µM -0.0380354548222082 0.456249450285529 no 1859 0.484829706805252 2464 25236292 SGTC_331 k048-0133 24.5 µM -0.039916796132552 0.455621403651149 no 1860 0.484079730198728 2477 6813582 SGTC_1462 k081-0014 26.5 µM -0.0405015801860732 0.455426208184264 no 1861 0.483846623635256 2454 3270634 SGTC_2362 9071156 126 µM -0.0426503659207611 0.454709056297575 no 1862 0.482990122895906 2514 653133 SGTC_1464 k208-0027 110 µM -0.0434197646098261 0.454452307166539 no 1863 0.482683461338615 2471 X1464 SGTC_1313 1220-0047 237 µM -0.0455727881044237 0.453733942488718 no 1864 0.481825379288411 2517 3528706 SGTC_383 2324-0395 7.37 µM -0.0457018313266405 0.453690891498808 no 1865 0.481773952074376 2545 3146421 SGTC_1084 voriconazole 435 nM -0.0467895769967454 0.453328022918292 no 1866 0.48134046814401 2490 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_975 1335-0046 28.5 µM -0.0478019911563226 0.452990319699875 no 1867 0.480937024829519 2517 16486740 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0489938952634788 0.452592788987349 no 1868 0.480462080486461 2503 147795 SGTC_1846 st056244 14.8 µM -0.0491826010353159 0.452529855099683 no 1869 0.480386888423734 2557 5393182 SGTC_984 1492-0255 2.91 µM -0.050351188879747 0.452140154497727 no 1870 0.479921266321202 2559 1585198 SGTC_937 3122-0005 46.7 µM -0.0503872853960814 0.452128117765848 no 1871 0.479906884150454 2478 759535 SGTC_1614 st002383 48.6 µM -0.050430073726583 0.45211384964092 no 1872 0.479889835750366 2487 1947235 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0540958451948094 0.450891699162911 no 1873 0.478429401228379 2490 23665772 A membrane-active detergent. SGTC_2825 7998094 58.44 µM -0.05427580225052 0.450831714241688 no 1874 0.478357714068044 2544 2987815 SGTC_3047 9092122 49.47 µM -0.0544370525075964 0.450777965794467 no 1875 0.478293479487396 2524 17173831 SGTC_1124 fisetin 1.16336 µM -0.0560938953956428 0.45022575412459 no 1876 0.477633503525968 2579 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1974 st069448 26.9 µM -0.0564825736246407 0.450096224883688 no 1877 0.4774786887971 2517 6323587 YNR016C ACC1 SGTC_2052 5265182 7.135 µM -0.0567873659847139 0.449994654806107 no 1878 0.47735728909058 2539 1239884 SGTC_108 0509-0257 621.132 µM -0.0573381618786387 0.449811113958683 no 1879 0.477137910779629 2512 536624 SGTC_2378 9074213 121.43 µM -0.0578446764977663 0.449642338365539 no 1880 0.476936175517026 2516 657714 SGTC_2478 5763493 32.33 µM -0.0578534250910412 0.449639423329184 no 1881 0.476932691168363 2520 1365576 YLR208W SEC13 SGTC_2305 7443522 69.23 µM -0.058172677416301 0.449533050129542 no 1882 0.476805542059424 2537 5415886 SGTC_972 1319-0219 195 µM -0.0602959256815208 0.448825687574328 no 1883 0.475959973439533 2554 23903702 SGTC_2924 9010168 62.78 µM -0.0610489154912299 0.448574867119765 no 1884 0.475660126372916 2585 2993929 SGTC_1074 carmofur 3.8 µM -0.0626849344414027 0.448029981161198 no 1885 0.475008697186295 2526 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1900 st060200 72.8 µM -0.0627033409923539 0.448023851304433 no 1886 0.475001368452042 2506 688945 SGTC_2294 7971431 200 µM -0.0629699067233234 0.44793507942484 no 1887 0.474895233851854 2580 5741572 SGTC_1609 st001574 46.4 µM -0.0642376407492722 0.447512933642428 no 1888 0.474390503144458 2526 3960012 SGTC_1477 0139-0234 16 µM -0.0643861789342629 0.447463475438946 no 1889 0.474331367402163 2513 620880 SGTC_2130 NSC 7 2.4545 µM -0.0651967225201924 0.447193606185684 no 1890 0.474008685314498 2554 21448 SGTC_1831 st055328 12 µM -0.0661036017215512 0.446891691120389 no 1891 0.473647671683291 2535 1103068 SGTC_1960 st011366 51.8 µM -0.0685777488962312 0.446068163687194 no 1892 0.472662865484464 2527 3972846 SGTC_1465 k213-0056 144 µM -0.0687732732230247 0.446003092689272 no 1893 0.472585046290663 2513 24048857 YMR208W ERG12 SGTC_2053 5265679 138 µM -0.0690738096227431 0.445903076240118 no 1894 0.472465434058377 2531 764595 SGTC_2211 7117706 200 µM -0.0703348228257734 0.445483457304287 no 1895 0.47196358325996 2523 822771 SGTC_1916 st067606 49.2 µM -0.0705297656045158 0.445418592936792 no 1896 0.471886005003758 2604 19590279 SGTC_1294 1000-1494 117 µM -0.0711783596961352 0.445202793235919 no 1897 0.471627902092908 2534 712797 YDL207W GLE1 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.0713480660040047 0.44514633136806 no 1898 0.471560370766503 2543 364106 SGTC_2281 7943571 200 µM -0.0721788341462616 0.444869948049411 no 1899 0.471229794568245 2563 1244024 SGTC_1090 efavirenz 20.7 µM -0.0728248990511621 0.444655031070721 no 1900 0.47097272849148 2572 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1664 st014217 9.02 µM -0.0731083367038315 0.444560749136121 no 1901 0.470859953841595 2547 3982782 SGTC_51 1013-0126 23.419 µM -0.0732106505559026 0.444526716503147 no 1902 0.470819245607628 2528 1627850 SGTC_979 1426-2828 121 µM -0.0740560428043494 0.44424552954786 no 1903 0.470482895965225 2620 747872 SGTC_2210 7115885 190.385 µM -0.0744604981706165 0.444111013066364 no 1904 0.470321985884832 2544 2927039 SGTC_3190 9110366 49.47 µM -0.074464564805959 0.444109660590141 no 1905 0.47032036802353 2548 17123768 SGTC_1213 1315-0166 115 µM -0.0781691328739423 0.442877872543689 no 1906 0.468846757631396 2662 768401 SGTC_1062 mesoridazine 14.2 µM -0.0785058733791197 0.442765931769537 no 1907 0.46871282918177 2528 4078 A neuroleptic. SGTC_1762 st045503 25.4615 µM -0.0799179634304895 0.442296568374494 no 1908 0.468151251387394 2592 4645554 SGTC_2533 agelasine 13.65 µM -0.0816030016290606 0.441736586017993 no 1909 0.467481207151588 2596 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1663 st014140 55.4 µM -0.0820488428846296 0.441588440716372 no 1910 0.467303936675935 2551 4207120 SGTC_8 0354-0001 70 µM -0.0820535211423235 0.44158688625592 no 1911 0.4673020765931 2551 4993152 SGTC_154 3389-1638 511.116 µM -0.0825332276780835 0.441427497328791 no 1912 0.467111348295311 2649 5238686 SGTC_2190 6049624 200 µM -0.0828238697016489 0.441330932233057 no 1913 0.46699579452766 2536 2265554 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0837556055872937 0.441021388821285 no 1914 0.466625372774197 2551 688667 SGTC_76 0433-0009 400.328 µM -0.0840706907521589 0.44091671865484 no 1915 0.466500113758197 2708 2841569 SGTC_2415 st077333 57.7 µM -0.0840839167055901 0.440912325130556 no 1916 0.466494855982645 2543 2766255 SGTC_582 0987-0078 156 µM -0.0842558562054358 0.440855209277555 no 1917 0.466426504595989 2556 1625765 SGTC_2704 st078022 71.1 µM -0.0856717538103064 0.440384915146977 no 1918 0.465863678372703 2621 54697681 SGTC_2046 4110841 106 µM -0.0858493745274794 0.44032592387863 no 1919 0.465793078065006 2581 44119630 YMR134W ERG29 SGTC_1755 st041960 45.185 µM -0.0864572033372847 0.440124062228973 no 1920 0.465551487711814 2646 2257073 SGTC_2583 asiatic acid 100 µM -0.0869195303758164 0.439970532542473 no 1921 0.465367737638378 2652 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1636 st007707 68.9 µM -0.088896834827313 0.439314010885373 no 1922 0.464581949518197 2613 403051 SGTC_1267 0828-0272 9.49 µM -0.0892367858748042 0.439201154172701 no 1923 0.46444686554038 2638 745334 SGTC_3028 9087778 49.47 µM -0.0905946312416759 0.438750426990589 no 1924 0.463907349019599 2581 17217395 SGTC_603 3794-0023 45.9 µM -0.0916833126442113 0.438389104221275 no 1925 0.463474828061949 2579 3802260 SGTC_2900 5328528 85.29 µM -0.0922826001653602 0.438190228415083 no 1926 0.463236756215324 2551 795359 SGTC_2958 9077254 16.72 µM -0.0926567800243818 0.438066063341072 no 1927 0.463088116891271 2701 16457351 SGTC_1441 4106-0040 13 µM -0.0949365655442939 0.437309688374066 no 1928 0.462182606283988 2568 2904180 SGTC_1899 st063254 59.6 µM -0.0965704841240513 0.436767736411789 no 1929 0.461533748583374 2562 3093813 SGTC_56 0957-0365 83.25 µM -0.0970471240888452 0.436609662739184 no 1930 0.461344485712437 2557 6752360 SGTC_2969 9091408 28.7 µM -0.0973099701742158 0.436522496353573 no 1931 0.461240119262497 2616 4286311 SGTC_1284 0929-0043 16 µM -0.0980922344583128 0.436263096057227 no 1932 0.460929526896708 2645 1239883 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0996416229730199 0.435749396950548 no 1933 0.460314423942885 2572 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3198 9112019 49.47 µM -0.10150600154392 0.435131406772575 no 1934 0.459574396812525 2594 45595555 SGTC_859 0439-0102 54.6 µM -0.101735687221138 0.435055283222897 no 1935 0.459483237394517 2576 610143 SGTC_2087 5276107 200 µM -0.10237019121185 0.434845005327025 no 1936 0.459231421655503 2587 144405 SGTC_3017 9080681 49.47 µM -0.104311368452591 0.434201803849743 no 1937 0.458461128205448 2653 16451914 SGTC_1242 0402-0103 60.1 µM -0.104769307354205 0.434050092913023 no 1938 0.458279432581775 2593 432868 SGTC_170 4197-0004 226 µM -0.105304812137387 0.433872697437249 no 1939 0.458066972337511 2710 218692 SGTC_2628 lathosterol 100 µM -0.106143630583832 0.433594850703073 no 1940 0.457734197225487 2701 6710616 SGTC_826 1683-5028 118 µM -0.108122431270745 0.43293953123633 no 1941 0.456949287439516 2670 722377 SGTC_409 arachidonic acid 100 µM -0.108787530721911 0.432719311547122 no 1942 0.456685507079501 2598 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3083 9117465 49.47 µM -0.109597479434703 0.432451159345271 no 1943 0.456364304868271 2691 16420915 SGTC_2831 7999036 19.48 µM -0.112978142455756 0.431332250172637 no 1944 0.455023942021622 2852 2988270 SGTC_522 1273-0010 11.6 µM -0.113282768838475 0.43123145389505 no 1945 0.454903188885526 2845 5705015 SGTC_1363 1636-0063 10.4 µM -0.114167930175944 0.430938592788816 no 1946 0.454552336830966 2611 6072185 SGTC_2695 st077686 51.995 µM -0.114307180313738 0.430892524471465 no 1947 0.454497145371316 2655 2876092 SGTC_366 0181-0206 4.31 µM -0.115210316404796 0.430593761551941 no 1948 0.45413921091022 2650 274874 SGTC_184 1494-0393 24.714 µM -0.115354684078467 0.430546007524101 no 1949 0.454081997988712 2598 3090647 SGTC_460 trequinsin 123 µM -0.115378567692935 0.43053810738532 no 1950 0.454072533002062 2601 5537 A vasodilator. SGTC_510 ag-490 170 µM -0.115627512293264 0.430455764013426 no 1951 0.453973878746334 2632 5328779 SGTC_328 k915-0120 63.5 µM -0.115929733545326 0.430355802394811 no 1952 0.453854115303182 2745 6624543 SGTC_189 3970-0742 2.116 µM -0.116226630602552 0.430257606133476 no 1953 0.453736465803679 2622 2891807 SGTC_119 0121-0043 24.815 µM -0.11749585024222 0.429837870872899 no 1954 0.453233566147512 2607 1092378 SGTC_765 1319-0117 244 µM -0.119932362959135 0.429032330407367 no 1955 0.452268363781585 2628 3487746 YGL099W LSG1 SGTC_2438 5259590 200 µM -0.119976944708496 0.429017593886399 no 1956 0.452250705736789 2724 1201127 SGTC_1583 clindamycin 39.6 µM -0.120854144544421 0.42872765516549 no 1957 0.451903281605826 2623 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2004 4023728 41.89 µM -0.121209241026996 0.428610296918283 no 1958 0.451762652402794 2668 360084 YDR527W RBA50 SGTC_194 1486-1323 56.904 µM -0.123012960984502 0.428014270942354 no 1959 0.45104841726902 2646 5178754 SGTC_1679 SEC14.276 6.7 µM -0.124285026734556 0.427594024837685 no 1960 0.450544801156458 2789 1005053 YMR079W SEC14 SGTC_2161 5662504 8.5105 µM -0.125380235926889 0.427232271744587 no 1961 0.450111267040537 2655 2859334 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.125423743595845 0.427217902204664 no 1962 0.450094045932246 2626 17037758 SGTC_1832 st054113 55 µM -0.126685403224337 0.426801248356719 no 1963 0.449594699642497 2623 1251267 SGTC_3207 9114163 49.47 µM -0.126727647686447 0.42678729884298 no 1964 0.449577981283348 2790 849233 SGTC_3267 9137951 49.47 µM -0.127625169981775 0.426490950311225 no 1965 0.44922280562621 2605 16643986 SGTC_1889 st059080 5.18 µM -0.127969708607081 0.426377199787452 no 1966 0.449086472469308 2617 176925 Isolated from Daphnopsis sellowiana. SGTC_2856 9022925 19.48 µM -0.12817887522326 0.426308145750285 no 1967 0.449003708642318 2764 4944862 SGTC_1096 rimcazole 32.2 µM -0.128352920757295 0.426250688270572 no 1968 0.448934843347319 2616 18528119 A dopamine reuptake inhibitor. SGTC_411 enrofloxacin 100 µM -0.128635904676807 0.426157270411863 no 1969 0.448822877249102 2756 71188 A bacterial gyrase inhibitor. SGTC_47 0149-0135 24.25 µM -0.129523431869713 0.425864309320803 no 1970 0.448471742582676 2587 5239155 SGTC_2517 totarol 10 µM -0.133216795250043 0.424645619668149 no 1971 0.44701096427234 2696 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1160 4092-0570 10.5 µM -0.133355264174727 0.424599943361712 no 1972 0.446956211674697 2633 4994975 SGTC_659 k018-0002 107 µM -0.13720657210947 0.42332993243249 no 1973 0.445433758125479 2710 6797879 YHR007C ERG11 SGTC_1293 1000-1278 195 µM -0.138165254124402 0.423013919797966 no 1974 0.445054907437649 2745 678847 SGTC_3302 9125395 16.351 µM -0.139337080602262 0.422627715135177 no 1975 0.444591894790116 2700 17599668 SGTC_2839 9003951 25.97 µM -0.140111201286912 0.422372625107267 no 1976 0.444286065274162 2629 2990634 SGTC_3076 9116187 49.47 µM -0.140563923326332 0.422223458179969 no 1977 0.444107225108019 2761 27241210 SGTC_890 0929-0006 47.2 µM -0.14058233493764 0.422217391992683 no 1978 0.444099952153707 2656 1378169 SGTC_1200 1643-0193 18.4 µM -0.142610647064223 0.421549224765112 no 1979 0.443298844147553 2636 5403974 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.142690791397824 0.421522828218266 no 1980 0.443267194847541 2678 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2226 7298446 200 µM -0.143441777971975 0.421275498471088 no 1981 0.442970645025799 2696 3283010 SGTC_420 mitomycin C 81.9 mM -0.143566795136537 0.421234328359719 no 1982 0.442921281304369 2664 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3236 9132701 49.47 µM -0.143893089593024 0.421126878540224 no 1983 0.442792446302714 2700 24282524 SGTC_3193 9111931 49.47 µM -0.144369987910838 0.420969844951428 no 1984 0.442604157342497 2675 17087244 SGTC_2207 7258803 200 µM -0.14448938865082 0.42093053051492 no 1985 0.44255701757821 2742 3666799 SGTC_804 1595-0054 20.9 µM -0.145070511969644 0.420739198444351 no 1986 0.442327600001286 2672 761523 Stimulates phospholipase C. SGTC_2813 7971799 71.43 µM -0.145393838714207 0.420632752764796 no 1987 0.442199964484725 2783 2234054 SGTC_1004 4084-0029 199 µM -0.145676661048268 0.420539646711266 no 1988 0.442088323289495 2788 716894 YLR208W SEC13 SGTC_1263 0774-1208 64.8 µM -0.146644922252426 0.420220925592177 no 1989 0.441706147062309 2736 906585 SGTC_1318 1280-3875 124 µM -0.146920979141164 0.420130065924639 no 1990 0.441597196327102 2732 373245 SGTC_2278 7948257 134.34 µM -0.14700731784432 0.420101649808131 no 1991 0.441563122137115 2665 1247028 SGTC_1009 4106-0057 9.87 µM -0.150225042560998 0.419042918473153 no 1992 0.440293534489957 2665 2928005 SGTC_2998 9066762 71.4286 µM -0.150671231542206 0.418896154534097 no 1993 0.440117534009541 2810 4945196 SGTC_1480 1070-0044 41.2 µM -0.151884698240184 0.418497068803269 no 1994 0.439638938651039 2769 3124987 SGTC_1184 1269-1718 139 µM -0.151975974431774 0.41846705321585 no 1995 0.439602942571339 2811 5403821 SGTC_1938 st074717 56.4 µM -0.152377269664821 0.418335095498453 no 1996 0.439444691948546 2632 17250979 SGTC_2394 5221648 200 µM -0.152746325303695 0.418213747223722 no 1997 0.439299163538477 2792 788586 SGTC_2723 salbutamol 83.58 µM -0.153123921922807 0.418089598667282 no 1998 0.439150275684366 2772 9884233 β2-adrenoceptor agonist SGTC_1158 4092-0494 91.8 µM -0.15458732166302 0.417608530244196 no 1999 0.438573332842665 2808 1148199 SGTC_880 0833-0487 87.2 µM -0.154824523491047 0.417530565664581 no 2000 0.438479828687362 2686 76075 SGTC_3314 9135860 59.4275 µM -0.154948121361387 0.417489942236876 no 2001 0.438431108186958 2708 25252478 SGTC_1569 carminic acid 40.6 µM -0.155414978900174 0.417336506170561 no 2002 0.438247088093324 2760 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1449 4112-4002 201 µM -0.155799940410325 0.417209995286808 no 2003 0.438095358798846 2700 2059539 SGTC_2252 omeprazole 400 µM -0.157296646873282 0.416718210378197 no 2004 0.43750553138613 2754 4594 A proton pump inhibitor. SGTC_2296 7971656 126.45 µM -0.157989664133821 0.416490544200456 no 2005 0.437232471626518 2752 666570 SGTC_2605 digitonin 300 nM -0.159176814317173 0.416100613352071 no 2006 0.436764785220953 2689 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1016 4226-1401 38 µM -0.159457275363844 0.416008505278535 no 2007 0.436654308442682 2658 2901613 SGTC_127 0180-0333 59.125 µM -0.160172504565914 0.415773633004695 no 2008 0.436372593955809 2656 771601 SGTC_866 0495-0101 262 µM -0.16033494517859 0.415720293739849 no 2009 0.436308616337257 2702 635694 SGTC_338 4055-0136 114 µM -0.16051959565693 0.415659663492971 no 2010 0.436235893334382 2691 2900563 SGTC_3328 9140624 29.0385 µM -0.161255330459682 0.415418103876429 no 2011 0.435946151938041 2860 4904392 SGTC_99 0109-0120 622.8 µM -0.161754335860732 0.415254286461525 no 2012 0.435749657039262 2717 759414 SGTC_3119 9125183 49.47 µM -0.166710318299958 0.413628101733004 no 2013 0.433798993165366 2774 22695334 SGTC_493 zm226600 134 µM -0.167557118575738 0.413350392184231 no 2014 0.433465854284475 2869 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1203 3992-3522 103 µM -0.1676108286319 0.413332779342977 no 2015 0.433444725854577 3053 5322312 SGTC_3196 9111891 49.47 µM -0.168481040721198 0.413047439840442 no 2016 0.433102428888964 2656 18891510 SGTC_2653 dihydrofissinolide 100 µM -0.169748834119701 0.412631817053467 no 2017 0.432603833632418 2757 6857746 SGTC_179 1273-0063 6.77 µM -0.1698123591001 0.412610994127814 no 2018 0.43257885347112 2721 3108139 SGTC_1064 honokiol 6.76 µM -0.169845500682519 0.412600130708398 no 2019 0.432565821191931 2779 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_203 k066-0004 30.888 µM -0.170349214046237 0.4124350276611 no 2020 0.43236775480054 2671 6795412 SGTC_2874 9043904 71.43 µM -0.170483193519717 0.412391115572268 no 2021 0.432315075256053 2790 4463428 SGTC_3348 9149464 3.537 µM -0.170784617764083 0.412292327074098 no 2022 0.43219656230806 2676 1951442 SGTC_2333 9017922 200 µM -0.173880257718353 0.411278087608332 no 2023 0.430979784164056 2848 3163164 SGTC_2791 5663188 71.43 µM -0.174060490059011 0.411219055409468 no 2024 0.430908961758027 2863 54690634 SGTC_311 1315-0136 58 µM -0.174259485029249 0.411153880148632 no 2025 0.430830769146308 2864 6759207 SGTC_410 α-linolenic acid 100 µM -0.175488517306204 0.41075139926212 no 2026 0.430347896319892 2847 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3 0833-0587 95.581 µM -0.177122967374333 0.410216298633383 no 2027 0.429705900894222 2747 5382644 SGTC_3293 9120939 62.045 µM -0.17858376186256 0.409738192291599 no 2028 0.429132272833901 2868 934087 SGTC_2096 5468907 200 µM -0.178960782679394 0.40961481815288 no 2029 0.428984247697279 2874 759785 SGTC_1466 k213-0079 57.5 µM -0.179091166794305 0.40957215408189 no 2030 0.42893305887772 2710 3657981 SGTC_691 1548-0686 185 µM -0.180446182820405 0.40912883149599 no 2031 0.428401150333519 2755 46495133 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.180983239084733 0.408953154132515 no 2032 0.428190366016576 2724 15053 SGTC_990 3985-0011 41.3 µM -0.18112727010249 0.408906043016469 no 2033 0.428133840076972 2802 5399565 YGL099W LSG1 SGTC_672 1441-0018 53.7 µM -0.182932983551295 0.408315523958179 no 2034 0.427425301216142 2717 251141 SGTC_2499 avocadenofuran 51.48 µM -0.183672493020789 0.408073743573839 no 2035 0.427135194574502 2712 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2701 st077767 14.721 µM -0.184558395924345 0.407784146382008 no 2036 0.4267877102545 2757 5721188 SGTC_14 0354-0009 295 µM -0.185221283787778 0.407567484624697 no 2037 0.426527737934591 2689 1713507 SGTC_539 4859-0462 2.54 µM -0.185387705845957 0.407513094800602 no 2038 0.42646247529951 2910 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_702 1488-0190 94 µM -0.185738773195668 0.407398365309292 no 2039 0.426324810369608 2838 949357 SGTC_1435 4092-0789 56.7 µM -0.186565079102848 0.407128358301615 no 2040 0.426000824396441 2806 2248285 SGTC_1805 st050013 60.3 µM -0.186668060878787 0.407094710656505 no 2041 0.425960449806137 2799 4037144 SGTC_1055 3448-0672 86 µM -0.186985923989465 0.406990858303817 no 2042 0.425835834664527 2883 748378 SGTC_2094 5332512 191.667 µM -0.188692290737623 0.406433465481329 no 2043 0.425166997074718 2884 755774 SGTC_1033 k072-0102 21.3 µM -0.18883429483679 0.4063870876941 no 2044 0.425111345988282 2890 5965931 SGTC_896 0964-0007 44.5 µM -0.189438295744408 0.406189838874219 no 2045 0.424874656079267 2695 6756758 SGTC_1630 st005209 31.3 µM -0.191113875339098 0.405642768947998 no 2046 0.424218188524646 2728 3367314 SGTC_248 streptozotocin 5.23457 mM -0.191182800836102 0.405620268991664 no 2047 0.424191189012675 2833 5300 DNA alkylating agent. SGTC_3282 9108498 15.4605 µM -0.191468459063161 0.405527022388653 no 2048 0.424079294698639 2837 16459645 SGTC_3292 9120825 59.784 µM -0.192862362963298 0.405072091302296 no 2049 0.423533380800841 2802 24824900 SGTC_1794 st048918 76.9 µM -0.19341981188308 0.404890191496302 no 2050 0.423315100375716 2703 672303 SGTC_3224 9130643 49.47 µM -0.193569620965119 0.404841311159374 no 2051 0.42325644360212 2940 17644395 SGTC_42 0133-0086 60.653 µM -0.19363760256093 0.404819130328288 no 2052 0.423229826410565 2714 162923 Model of phenazepam hydroxylation. SGTC_1216 1165-0504 9.65 µM -0.197325362539807 0.403616359145398 no 2053 0.421786466540769 2839 6304004 SGTC_2822 7994718 71.43 µM -0.197333922575141 0.403613568326043 no 2054 0.421783117425237 2698 1018011 SGTC_2308 7584454 197.62 µM -0.199297742079981 0.402973436298743 no 2055 0.421014922653039 2894 893577 SGTC_568 1193-0097 7.48 µM -0.200873754649735 0.402459902829539 no 2056 0.420398645084566 2819 3646150 SGTC_601 0986-0029 62.9 µM -0.201224177671816 0.40234574259828 no 2057 0.420261643543054 2779 24747981 SGTC_234 nsc-17383 10.7 µM -0.202093666450684 0.402062517974406 no 2058 0.419921749576942 2905 408974 SGTC_1720 st037298 9.481 µM -0.202119307005196 0.402054166678128 no 2059 0.419911727270937 2853 597396 SGTC_2336 9001819 198.65 µM -0.202350130218665 0.401978988061689 no 2060 0.419821506098083 2990 2989602 SGTC_888 0916-0002 6.97 µM -0.203552367278862 0.401587480772268 no 2061 0.419351659562439 2936 2802138 YIL048W NEO1 SGTC_1691 st019933 84.6 µM -0.203844302708463 0.401492427180939 no 2062 0.41923758553469 2748 6176082 SGTC_864 0469-0573 172 µM -0.2039992616102 0.401441975240462 no 2063 0.419177037963853 2746 689425 SGTC_635 k038-0028 24.7 µM -0.204522547878462 0.401271614421637 no 2064 0.418972586855154 2802 4035102 SGTC_1579 chlormadinone acetate 49.4 µM -0.205422404582902 0.400978701419701 no 2065 0.418621058593919 2928 45114258 A steroidal progestin. SGTC_1122 capsaicin 818.572 nM -0.207764814140395 0.400216483392811 no 2066 0.417706303664966 2912 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2915 7971052 15.16 µM -0.209039380435639 0.399801900048311 no 2067 0.417208748256548 2759 5741558 SGTC_2216 7189485 200 µM -0.209542834458837 0.399638170604745 no 2068 0.417012250214632 2874 731273 SGTC_2912 7964298 10.93 µM -0.209803296989117 0.399553471909297 no 2069 0.416910599854798 2858 2975850 SGTC_443 clozapine 122 µM -0.210545459468122 0.399312157205599 no 2070 0.416620987591916 2745 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3007 9078383 71.4286 µM -0.210708882378448 0.399259025284584 no 2071 0.41655722154008 2819 6496995 SGTC_2060 5238662 140 µM -0.210958778813715 0.399177782771628 no 2072 0.41645971859482 2879 790130 SGTC_653 0203-0016 55.2 µM -0.212349438709131 0.398725752522124 no 2073 0.415917214128993 2831 295302 SGTC_657 3534-0529 86.7 µM -0.21355288235247 0.398334686005729 no 2074 0.415447873055551 2952 1049549 SGTC_101 0490-5701 117.494 µM -0.213617808063245 0.398313590889949 no 2075 0.415422555556419 2745 4661669 SGTC_3202 9113761 49.47 µM -0.215692853110105 0.397639541552631 no 2076 0.41461358624535 2975 4798415 SGTC_2316 5844804 197.44 µM -0.216489691240116 0.397380780910014 no 2077 0.414303029921659 2916 776813 SGTC_1534 6-azauridine 81.6 µM -0.21690368316833 0.397246361363551 no 2078 0.41414170359143 2759 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_157 1348-1695 65.819 µM -0.217819256505295 0.39694912609521 no 2079 0.413784970130085 2790 5380510 SGTC_916 4466-0038 42 nM -0.218329998380287 0.396783342874138 no 2080 0.413586001433163 2942 5722064 YGL116W CDC20 SGTC_2100 5377183 190 µM -0.218684084146796 0.396668420071462 no 2081 0.41344807396412 2887 2844202 SGTC_1296 1068-0102 11.9 µM -0.219315341857985 0.396463560043244 no 2082 0.4132022058649 2894 767053 SGTC_296 1222-0039 74.9 µM -0.219393418321669 0.396438224125332 no 2083 0.413171798284133 2826 5984176 SGTC_1269 0831-0796 3.05 µM -0.219902709577559 0.396272969159339 no 2084 0.412973463013372 2914 927758 SGTC_2303 7774051 200 µM -0.220088653598976 0.396212638634879 no 2085 0.412901055643808 2969 2953184 SGTC_2779 methotrexate 400 µM -0.221027922008957 0.395907926030751 no 2086 0.412535345984631 2848 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1618 st003135 44.5 µM -0.2234968920669 0.395107259281254 no 2087 0.4115744008661 2730 1270615 SGTC_1735 st034310 56.75 µM -0.223880584480861 0.394982870635617 no 2088 0.411425111815822 3009 871153 SGTC_703 3875-0075 71.8 µM -0.22986390915651 0.393044538239665 no 2089 0.409098760868255 2836 2850814 SGTC_934 2950-0684 338 µM -0.231143865956556 0.392630231175248 no 2090 0.408601518789526 3027 1121253 SGTC_1412 3909-8563 178 µM -0.233718545231016 0.391797206436186 no 2091 0.407601744718406 2914 23767530 SGTC_943 3253-1379 105 µM -0.234217417343719 0.391635856057879 no 2092 0.40740809698049 2984 668464 SGTC_1882 5615643 20 µM -0.234475280714909 0.391552462525057 no 2093 0.407308010738507 2790 2253075 SGTC_764 1951-2361 146 µM -0.23451403045931 0.391539931210426 no 2094 0.407292971062824 2839 5438930 SGTC_1807 st050092 58.9 µM -0.234853919327117 0.391430019069049 no 2095 0.407161058159302 2836 5008496 SGTC_917 harmaline 728.087 nM -0.235659953029496 0.391169401214105 no 2096 0.406848273775284 2930 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1126 isoteolin 1.0172 µM -0.237159095809878 0.390684807863648 no 2097 0.406266683973819 2825 133323 SGTC_2636 apigenin dimethyl ether 100 µM -0.239339559697893 0.389980282676485 no 2098 0.405421146207597 2972 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3312 9133330 71.43 µM -0.241891971199631 0.389156037341068 no 2099 0.404431935741459 2986 17617324 SGTC_2469 5655019 90.81 µM -0.243216891146923 0.388728379809563 no 2100 0.403918691214998 2964 2788239 SGTC_85 0868-0259 160.055 µM -0.243638395980901 0.388592354762735 no 2101 0.403755444246728 2895 83173 SGTC_2003 4023581 200 µM -0.244141485803366 0.388430019070706 no 2102 0.403560621718426 2981 16641307 SGTC_425 3825-7017 13.1 µM -0.244701047701728 0.388249484009921 no 2103 0.403343958376335 3093 3397440 SGTC_485 niflumic acid 177 µM -0.244794113674457 0.388219459876155 no 2104 0.403307925945006 2956 4488 A COX2 inhibitor. SGTC_2663 amphotericin b 100 µM -0.248208517032571 0.387118398025364 no 2105 0.401986538437005 2859 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1394 3474-0001 65.7 µM -0.249468610431882 0.386712277441448 no 2106 0.401499159359773 2886 5017666 YIL048W NEO1 SGTC_59 0330-0160 1.33 µM -0.250140713570254 0.38649571330093 no 2107 0.401239265823045 2873 4293482 SGTC_3345 9148410 3.559 µM -0.250830825267595 0.38627338324852 no 2108 0.400972454073311 2984 4903596 SGTC_938 3126-1755 342 µM -0.252098337826419 0.38586513197555 no 2109 0.400482527352793 3011 1777771 SGTC_2073 5212005 126 µM -0.253216335466695 0.38550514262253 no 2110 0.400050521949319 2800 691789 SGTC_274 sirtinol 40.1 µM -0.253384184669928 0.385451104569447 no 2111 0.399985673893456 2879 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2891 9063876 19.48 µM -0.256760738413966 0.384364516800003 no 2112 0.398681740179535 2970 6472478 SGTC_2580 diallyl disulphide 81.36 µM -0.257484193439023 0.384131824063584 no 2113 0.398402507936937 2873 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3215 9129942 49.47 µM -0.258061380905684 0.383946206901711 no 2114 0.398179767939253 2982 17682944 SGTC_620 0109-0052 432 µM -0.258194476947628 0.38390340844907 no 2115 0.398128410107607 2992 493037 SGTC_754 3474-0146 171 µM -0.262873129066106 0.382399841194032 no 2116 0.396324184010187 2855 24762078 SGTC_1152 3909-8331 15.9 µM -0.262987516389938 0.382363102904303 no 2117 0.39628010051048 2890 16001939 SGTC_46 0329-0187a 2.197 µM -0.263038778945376 0.38234663902308 no 2118 0.396260344968059 2960 46494817 SGTC_836 0330-0104 1.35 µM -0.263580804972444 0.382172570745386 no 2119 0.39605147551029 2882 46494820 SGTC_1382 3002-2117 298 µM -0.268579487386038 0.380568401698352 no 2120 0.39412664958021 3037 1497314 SGTC_1834 st055981 52.8 µM -0.270926872456501 0.379815788832121 no 2121 0.393223638235688 3032 471719 YDL150W RPC53 SGTC_2348 9022543 33.42 µM -0.273041361577186 0.379138235908996 no 2122 0.392410710575992 3028 3162678 YDL140C RPO21 SGTC_2160 5660466 132.927 µM -0.274126908696563 0.378790534404173 no 2123 0.391993547723864 2908 2859134 SGTC_225 nsc-122657 1.016 µM -0.275829249269423 0.378245471111415 no 2124 0.391339608593757 3005 275685 SGTC_2823 7987624 58.44 µM -0.276074382767656 0.378167003056935 no 2125 0.391245467964992 3121 2239440 SGTC_2222 6885208 172.143 µM -0.276134652981509 0.378147711128958 no 2126 0.391222322875756 2931 609514 SGTC_1736 st036774 51 µM -0.277567210086957 0.377689252618636 no 2127 0.390672302964048 3137 1272247 SGTC_60 0986-0278 202 µM -0.281761892478934 0.376347829218613 no 2128 0.389063046439514 2896 3110598 SGTC_680 0417-1641 114 µM -0.28309352212961 0.37592229675149 no 2129 0.388552573582751 2879 2835990 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.283899768528021 0.375664727807069 no 2130 0.388243596944726 2898 6708784 An antioxidant flavonoid SGTC_3090 9117696 49.47 µM -0.284349277584484 0.375521148640457 no 2131 0.3880713629325 2972 7923821 SGTC_104 0074-0074 590.992 µM -0.285340336344924 0.375204652228776 no 2132 0.387691706403161 2829 3943124 SGTC_1415 3966-0071 78.1 µM -0.285803385152497 0.3750568055307 no 2133 0.387514357627226 2947 2893185 SGTC_652 0437-0092 114 µM -0.288046104707242 0.374340988478437 no 2134 0.386655723532026 2923 3091274 SGTC_395 anisomycin 6.25 µM -0.288336354894201 0.374248379847442 no 2135 0.386544640535782 2967 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2170 morpholine 200 µM -0.290714709743679 0.373489804186586 no 2136 0.385634760263565 3041 121171 Reacts with secondary amines. SGTC_2514 salinomycin 42.74 µM -0.291349866012961 0.373287304032243 no 2137 0.385391876590491 3097 23682228 A polyether potassium ionophore. SGTC_633 0437-0093 97.7 µM -0.291494446011962 0.373241214007781 no 2138 0.385336595494239 2927 2831118 SGTC_2473 5854593 8.94 µM -0.29257874962119 0.372895611459306 no 2139 0.384922079334528 2890 2872951 SGTC_413 propylparaben 100 µM -0.295236441703851 0.372048952293895 no 2140 0.383906632782378 2910 7175 A pharmaceutical preservative. SGTC_1742 st038235 28.8875 µM -0.295559811663134 0.371945978653947 no 2141 0.383783134346784 3045 564103 YBR002C RER2 SGTC_1342 1486-1464 234 µM -0.29687060814868 0.371528663674601 no 2142 0.38328264820388 2922 3253938 SGTC_862 0452-0056 10.2 µM -0.296997593355607 0.371488243726211 no 2143 0.383234173255567 3006 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_667 1498-1044 59 µM -0.297023024831563 0.371480148946157 no 2144 0.38322446534066 2969 6739982 SGTC_2288 7946289 167.31 µM -0.297262892088046 0.371403802549146 no 2145 0.38313290482124 3137 1246052 SGTC_1194 1488-0194 225 µM -0.298112049749713 0.371133568202772 no 2146 0.382808822553577 2895 1391452 SGTC_1130 3454-2858 15.9 µM -0.298825662206479 0.37090651862906 no 2147 0.382536534737059 3021 715628 YIL048W NEO1 SGTC_1574 spiramycin 23.7 µM -0.299170257318381 0.370796895129208 no 2148 0.382405070913012 2888 6419898 An antibiotic and protein synthesis inhibitor. SGTC_844 0330-0132 15.3 µM -0.300845836693624 0.370264005047106 no 2149 0.381766026966225 3054 2828079 SGTC_1567 st069303 68.4 µM -0.303634986310417 0.369377514946922 no 2150 0.380702996997432 3040 5581319 SGTC_1198 1612-1005 86.7 µM -0.304670739664508 0.36904849248249 no 2151 0.380308468543809 3129 6998509 SGTC_910 3454-3003 490 µM -0.305549236138318 0.368769500180571 no 2152 0.379973938303826 3069 820824 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.305795496516102 0.368691305382087 no 2153 0.379880178794813 3123 688798 SGTC_1874 staurosporine 7.6 µM -0.30608614944847 0.36859902165715 no 2154 0.379769526649662 3067 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_442 cape 100 µM -0.307277432088936 0.368220862833132 no 2155 0.379316105942624 3075 5281787 SGTC_996 3970-0799 1.8 µM -0.307639711858775 0.3681058866258 no 2156 0.379178249505454 3000 6615648 YGL040C HEM2 SGTC_689 0833-0039 98 µM -0.307849577183415 0.368039287374022 no 2157 0.379098397571375 2987 5374726 SGTC_2447 5741742 33.78 µM -0.310224632952937 0.367285857368959 no 2158 0.37819506978364 3045 1776504 SGTC_3005 9076496 71.4286 µM -0.312468314987398 0.366574571559969 no 2159 0.377342319695484 3058 21368410 SGTC_3238 9133470 49.47 µM -0.314276637728343 0.366001635313012 no 2160 0.376655470180493 3098 3534688 SGTC_1333 1482-0047 286 µM -0.316026144885659 0.3654476180025 no 2161 0.375991331784757 3098 3811116 SGTC_2116 5511452 16.8835 µM -0.316992097576673 0.365141849441994 no 2162 0.375624799253696 3075 870744 SGTC_769 0302-0231 76 µM -0.317029436305146 0.365130031732555 no 2163 0.375610633254956 3069 571869 YER009W NTF2 SGTC_3248 9135562 49.47 µM -0.317316004923878 0.36503933701498 no 2164 0.375501917120871 3014 17650701 SGTC_2120 5538279 151.968 µM -0.317829638082454 0.364876798633316 no 2165 0.375307083782165 2992 2058197 SGTC_625 k213-0058 121 µM -0.318560485424165 0.364645565033741 no 2166 0.375029910743021 3025 3655420 SGTC_1418 3966-3099 2.4 µM -0.319123593533768 0.364467436212658 no 2167 0.374816396623147 3058 740335 SGTC_3246 9135460 32.98 µM -0.320783006100226 0.363942682094126 no 2168 0.374187419271036 3054 41446951 SGTC_1340 1486-1359 257 µM -0.322123874189645 0.363518847176619 no 2169 0.373679426227504 2979 4309068 SGTC_1321 1326-2144 215 µM -0.322328136472947 0.363454296568055 no 2170 0.373602059908068 3079 3513030 SGTC_1685 st024049 53.0905 µM -0.324731167949 0.362695186309986 no 2171 0.372692271669334 3045 1941139 SGTC_18 0111-0177 500 nM -0.325874090245408 0.36233432974456 no 2172 0.372259809783514 2998 721752 SGTC_1458 k015-0034 6.33 µM -0.327337280248652 0.361872533103058 no 2173 0.371706399297664 3029 3598957 SGTC_1700 st030840 7.9285 µM -0.329654462768156 0.361141619843452 no 2174 0.370830532699789 3093 5499307 SGTC_426 0988-0037 14.6 µM -0.335972248999267 0.359151369362082 no 2175 0.368445896705173 3200 5383008 SGTC_1353 1498-1206 8.11 µM -0.336715379333512 0.358917515743685 no 2176 0.368165734339847 3029 6756808 SGTC_2634 4'-methoxyflavone 100 µM -0.338828806521455 0.358252736445713 no 2177 0.367369349547098 3056 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1902 st060212 70.5 µM -0.338983660605485 0.358204043898697 no 2178 0.367311019576978 3044 688944 SGTC_1360 1598-0022 39.8 µM -0.341431892638882 0.357434525105073 no 2179 0.366389234580018 3122 761525 SGTC_946 3434-1334 87.4 µM -0.342228403159 0.357184293753056 no 2180 0.36608950584301 3138 4047976 SGTC_1775 st081588 35.1725 µM -0.34350977427025 0.356781867736738 no 2181 0.365607494443263 3026 1426443 YGL099W LSG1 SGTC_2285 7945142 200 µM -0.34423688450737 0.356553583119594 no 2182 0.365334072792218 3125 2970608 SGTC_1073 triclabendazole 3.09 µM -0.345296145849311 0.356221107809298 no 2183 0.364935871933719 3090 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2852 9023854 51.95 µM -0.345510076116056 0.356153973771282 no 2184 0.36485546825614 3174 19798528 SGTC_259 usnic acid 108.925 µM -0.346008960912061 0.355997434704627 no 2185 0.364667990194363 3221 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2370 9071495 200 µM -0.347418530252443 0.355555274124808 no 2186 0.364138457087613 3088 21791103 SGTC_74 000s-0487 160.283 µM -0.347464537055486 0.355540845758091 no 2187 0.364121178069582 3039 677548 SGTC_865 0488-0499 301 µM -0.348316419846602 0.355273721012045 no 2188 0.363801281892679 3183 9634651 SGTC_838 0109-0203 71.4 µM -0.348623865181367 0.355177332881672 no 2189 0.363685854344858 3008 759422 SGTC_1815 st051655 58.2 µM -0.351268496022797 0.35434858977273 no 2190 0.362693463712393 3133 5984156 SGTC_1771 st048882 4.1505 µM -0.351375994742712 0.354314917647307 no 2191 0.362653144554174 3004 4580403 SGTC_608 k048-0125 159 µM -0.352013902282507 0.354115127518321 no 2192 0.36241391821385 3141 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_253 dyclonine 31.25 µM -0.353348851814057 0.353697156574634 no 2193 0.361913463010498 3042 3180 An oral anasthetic. SGTC_957 1187-1561 14.1 µM -0.355104754331096 0.353147654323742 no 2194 0.36125555751386 3098 1538454 SGTC_1444 4112-3581 28 µM -0.355451897818942 0.353039053440736 no 2195 0.361125537509016 3050 2877249 SGTC_2680 butyl paraben 22.24 µM -0.356055062937422 0.352850386842733 no 2196 0.360899664672253 3087 7184 An antifungal and steroid mimetic. SGTC_2114 5491910 81.25 µM -0.35644497389177 0.352728444176829 no 2197 0.360753676907618 3157 2849228 SGTC_1373 2887-0003 58.5 µM -0.357054483959837 0.352537853320494 no 2198 0.360525509013404 3090 776948 SGTC_149 3970-0822 46.1 µM -0.357184066962959 0.352497338110442 no 2199 0.360477006481329 3143 3114250 YBL034C STU1 SGTC_249 wiskostatin 11.211 µM -0.357507485522006 0.352396225893265 no 2200 0.360355961672994 3138 2775510 A n-wasp and actin depolymerizer. SGTC_285 1486-1325 46 µM -0.358515264513151 0.352081225027485 no 2201 0.359978873316496 3149 22310230 SGTC_1233 0325-0408 14.2 µM -0.361812174468636 0.351051421870805 no 2202 0.358746196876469 3149 12874 SGTC_103 0844-0104 51.839 µM -0.362377280443788 0.350875018249257 no 2203 0.358535057505867 3158 5375804 SGTC_169 k015-0017 16.025 µM -0.364036772550315 0.350357176672225 no 2204 0.357915275030839 3282 1840002 SGTC_1994 st072947 40.9 µM -0.364054326114928 0.350351700597826 no 2205 0.357908721172557 3161 5286565 YDL195W SEC31 SGTC_1626 st003712 1.76 µM -0.365563428844025 0.349881031777527 no 2206 0.357345434233001 3193 24207035 SGTC_340 k038-0059 454 µM -0.365576779905291 0.349876868789256 no 2207 0.357340452207212 3088 23733424 SGTC_2833 9001315 45.46 µM -0.365737405311679 0.349826785669924 no 2208 0.357280515813394 3010 2989378 SGTC_2750 bromebric acid 70.15 µM -0.366264152520135 0.349662563842608 no 2209 0.357083988007955 3207 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1906 st060206 94.7 µM -0.366708318269872 0.349524109956439 no 2210 0.356918300557951 3181 5133468 SGTC_1493 4348-0038 111 µM -0.367880170149954 0.349158920250845 no 2211 0.356481293447355 3140 800424 SGTC_851 0394-0702 453 µM -0.368826680356166 0.348864056746684 no 2212 0.356128458256922 3191 762646 SGTC_670 4204-0025 119 µM -0.369813850351107 0.348556623833349 no 2213 0.355760597326194 3144 719039 SGTC_2545 solidagenone 89.61 µM -0.37077112609915 0.348258595804415 no 2214 0.355404004474909 2962 6708572 An anti ulcer agent SGTC_907 3448-6986 75.5 µM -0.371479155921644 0.348038225597225 no 2215 0.355140339113517 3233 590582 SGTC_2179 6298986 200 µM -0.372566820556516 0.347699796212008 no 2216 0.354735435514228 3187 738374 SGTC_1656 st012921 11 µM -0.374041962009176 0.34724099640642 no 2217 0.354186548581617 3151 6732821 SGTC_1104 tacrolimus 29.8 µM -0.374131384789672 0.34721319124088 no 2218 0.354153284888279 3105 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1151 3909-8316 15.3 µM -0.375996961083165 0.346633295731852 no 2219 0.353459577622582 3177 800431 SGTC_525 k781-2675 26.7 µM -0.376705413539299 0.346413174479209 no 2220 0.353196269663912 3154 3651118 YDL195W SEC31 SGTC_1503 4585-0012 61.3 µM -0.376762123117267 0.34639555664795 no 2221 0.353175195656168 3234 2922052 SGTC_1510 1123-0200 71.5 µM -0.379654826958217 0.34549732870408 no 2222 0.352100828289143 3287 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3217 9129673 49.47 µM -0.380277859233059 0.3453039814407 no 2223 0.351869584489198 3249 17248312 SGTC_2358 9037157 4 µM -0.3812966286957 0.344987910987325 no 2224 0.351491577480853 3164 2388925 SGTC_3313 9133968 57.047 µM -0.381441908566893 0.344942847106665 no 2225 0.351437684392716 3119 1494643 SGTC_1309 pyrazolanthrone 13.4 µM -0.386885935348931 0.343255772810491 no 2226 0.349420326948566 3200 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1497 4476-2978 41.3 µM -0.387034744722846 0.343209701238451 no 2227 0.349365242996053 3159 1528379 SGTC_2319 6033012 152.6 µM -0.388487858214027 0.342759938017876 no 2228 0.348827518818653 3074 847246 SGTC_808 0711-0032 135 µM -0.389252549436659 0.342523342564746 no 2229 0.34854466688723 3190 4252555 SGTC_821 1114-0266 29.2 µM -0.38992280211248 0.342316017193942 no 2230 0.348296816089827 3174 3123235 SGTC_1291 0993-0025 5.79 µM -0.390885428361177 0.342018336736768 no 2231 0.347940962645622 3203 4353356 SGTC_1032 k061-1018 98.7 µM -0.39109287623854 0.341954198855709 no 2232 0.347864293042481 3278 4005393 SGTC_529 4076-0302 30.3 µM -0.391698542537226 0.34176696754289 no 2233 0.347640483524182 3095 5816522 SGTC_446 go6976 132 µM -0.391920736494511 0.341698289859767 no 2234 0.347558390360062 3206 3501 A protein kinase C inhibitor. SGTC_378 3970-0959 8.33 µM -0.394037189351856 0.341044380728634 no 2235 0.346776791328122 3207 6615653 SGTC_1645 Cervolide 78 µM -0.394048999074135 0.341040733278785 no 2236 0.346772431861999 3151 23173 A fragrance. SGTC_1949 st076024 69.1 µM -0.394981435399701 0.340752795882602 no 2237 0.346428294400993 3042 2921930 SGTC_3305 9127027 53.8275 µM -0.395756685486269 0.340513468388042 no 2238 0.3461422666698 3107 41905295 SGTC_1306 1185-0270 9.02 µM -0.396734609301069 0.340211665061277 no 2239 0.345781587839823 3211 1548076 SGTC_2174 5790901 200 µM -0.396788886394179 0.340194917256073 no 2240 0.345761573404 3180 786020 SGTC_5 0352-0601 109.883 µM -0.397600165299532 0.339944625648901 no 2241 0.34546246932712 3150 762456 SGTC_3304 9125678 46.087 µM -0.39823180065501 0.339749805576131 no 2242 0.34522966340679 3098 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1277 0873-0036 22 µM -0.398801672758806 0.339574072335017 no 2243 0.345019672208478 3210 5965735 SGTC_2737 bleomycin 30.5 nM -0.399255773584021 0.33943406480785 no 2244 0.344852375530023 3158 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1180 1193-0155 285 µM -0.400877893997454 0.338934116715312 no 2245 0.344255013043938 3225 2921347 SGTC_3067 9117431 49.47 µM -0.401041331187027 0.33888376001725 no 2246 0.344194847133791 3122 17150885 SGTC_2955 9076254 12.21 µM -0.401164079121319 0.338845941995056 no 2247 0.344149662696755 3204 16459619 SGTC_1568 digitonin 820 nM -0.401500816755089 0.338742203162123 no 2248 0.344025718468997 3281 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_791 1348-1292 225 µM -0.403893570959316 0.3380054195176 no 2249 0.343145492092772 3144 5437054 SGTC_360 0957-0399 1.01 µM -0.405675398678467 0.337457156728368 no 2250 0.342490560336311 3247 6752301 YPR165W RHO1 SGTC_1262 0737-0114 49.6 µM -0.406146025342965 0.33731240391235 no 2251 0.342317654898751 3279 765919 SGTC_849 0386-0493 241 µM -0.409529707035477 0.33627237928554 no 2252 0.341075485232629 3103 726119 SGTC_129 0088-0017 176.636 µM -0.409901299232322 0.33615824106773 no 2253 0.340939176136418 3239 182446 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.41011854986458 0.336091517383145 no 2254 0.340859492912724 3220 7104 SGTC_2355 9061122 103.12 µM -0.410657646453211 0.335925968204281 no 2255 0.340661793647072 3205 5302957 SGTC_1706 st031321 9.9705 µM -0.413832309670368 0.334951719097272 no 2256 0.339498460007675 3239 6103185 SGTC_2539 epi(13)torulosol 80 µM -0.41820523964024 0.333611560409788 no 2257 0.337898532603885 3231 6708597 SGTC_2269 7935389 174.42 µM -0.421152855418784 0.332709408559395 no 2258 0.336821733820589 3161 97605 SGTC_355 1311-2252 105 µM -0.422163379096751 0.33240034862422 no 2259 0.336452884720929 3164 5338538 SGTC_837 0091-0265 12.5 µM -0.422992760551896 0.332146774577115 no 2260 0.33615027149171 3148 759367 SGTC_1725 st036284 20.55 µM -0.424906063758716 0.331562096888122 no 2261 0.335452577049804 3326 707914 SGTC_3138 9097216 49.47 µM -0.425258126421688 0.331454556288024 no 2262 0.335324257549709 3221 25237486 SGTC_283 0987-0079 11.7 µM -0.425263562041608 0.331452896039573 no 2263 0.335322276530135 3251 411556 SGTC_2795 7780010 54.55 µM -0.426904949062003 0.33095170462243 no 2264 0.334724280338141 3278 953673 SGTC_1492 4158-0558 28.5 µM -0.42737763255185 0.330807428595724 no 2265 0.334552148165401 3231 3967268 SGTC_1835 st008666 49.2 µM -0.427735705383436 0.330698151626934 no 2266 0.334421775694336 3125 690455 SGTC_1425 4048-4433 7.33 µM -0.42806091332146 0.330598916896278 no 2267 0.334303386462775 3253 23734946 SGTC_3240 9133527 49.47 µM -0.42866244165174 0.330415396483352 no 2268 0.334084448541572 3170 17617455 SGTC_314 1671-0008 2.74 µM -0.42895500693612 0.33032615241175 no 2269 0.333977984122181 3184 3913060 SGTC_2933 9026794 32.47 µM -0.429783491885785 0.330073483853958 no 2270 0.333676571206298 3165 17586027 SGTC_561 1550-0330 72.9 µM -0.430055633074495 0.329990504049428 no 2271 0.333577586331669 3160 6812934 SGTC_1403 3909-7815 62.9 µM -0.430947247570559 0.329718696438114 no 2272 0.333253363978828 3138 6615483 SGTC_592 k241-0073 46.5 µM -0.431696853336446 0.329490249577926 no 2273 0.332980877358011 3287 4230158 SGTC_512 prima-1 270 µM -0.433813917240424 0.328845405435866 no 2274 0.332211787233198 3305 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1658 st012944 20 µM -0.434271355070424 0.32870613962259 no 2275 0.332045701197822 3223 24207260 SGTC_1400 3771-8998 51.5 µM -0.434830038503727 0.328536082101708 no 2276 0.331842899771263 3161 670767 SGTC_1896 st058441 89 µM -0.434832000515064 0.328535484948083 no 2277 0.331842187650237 3180 688759 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.435614485031569 0.328297364542879 no 2278 0.331558229762203 3248 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_165 k038-0023 64.381 µM -0.436884962453592 0.327910890006114 no 2279 0.331097389014673 3167 46368543 SGTC_3044 9093193 49.47 µM -0.439409583241805 0.32714345673376 no 2280 0.330182391926085 3252 25236277 SGTC_3223 9129970 49.47 µM -0.440452826095035 0.326826545201137 no 2281 0.329804585876817 3144 17248386 SGTC_2619 obliquin 87.91 µM -0.440617985446506 0.32677638529448 no 2282 0.329744790011402 3148 6708593 A bioactive alkalod. YER133W GLC7 SGTC_12 0849-0099 9.267 µM -0.441187717181926 0.326603378306531 no 2283 0.329538552307874 3243 6071388 SGTC_1205 4161-2785 76 µM -0.442290502820106 0.326268608019673 no 2284 0.329139501254759 3260 3498106 SGTC_1452 4194-0072 190 µM -0.443193598888311 0.325994561265866 no 2285 0.328812854242949 3310 1343545 SGTC_217 ketoconazole 989 nM -0.44497574079343 0.325454041633941 no 2286 0.328168642799259 3250 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1958 st076513 41.9 µM -0.447129318773733 0.324801355885247 no 2287 0.327390845618458 3164 732122 YGL099W LSG1 SGTC_1163 k060-0048 49.9 µM -0.447167668142159 0.324789738191842 no 2288 0.327377001940848 3193 6809982 SGTC_1143 3454-2408 5.08 µM -0.447255905405626 0.324763007930145 no 2289 0.327345150212764 3268 X1143 SGTC_762 1165-0429 115 µM -0.447722583730995 0.324621649179172 no 2290 0.327176710422674 3283 5967793 SGTC_2592 piperlongumine 83.33 µM -0.448724323646281 0.324318303432294 no 2291 0.326815267917592 3228 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3206 9114350 49.47 µM -0.449099661868828 0.324204673944282 no 2292 0.326679882179974 3270 17087243 SGTC_992 3909-8734 162 µM -0.44934420640793 0.324130649602354 no 2293 0.326591686432428 3216 4288319 SGTC_349 k015-0014 24 µM -0.450033415085719 0.323922061550326 no 2294 0.326343173339142 3127 2196908 SGTC_401 neomycin 50 µM -0.450104017325451 0.3239006970006 no 2295 0.326317720115256 3219 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_536 3852-0578 10.6 µM -0.450407231620077 0.323808949611695 no 2296 0.326208415764659 3324 2869208 SGTC_3272 9137413 49.47 µM -0.451721753306947 0.323411322000334 no 2297 0.32573472251315 3215 17614870 SGTC_1843 st055809 45.5 µM -0.45205465846408 0.323310654013681 no 2298 0.325614803380167 3289 16413835 SGTC_2684 capsaicin 100 µM -0.452236716607825 0.323255606486896 no 2299 0.325549230007341 3304 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1080 nisoldipine 24.4 µM -0.45245266795797 0.323190315948027 no 2300 0.32547145604068 3143 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1109 tnp00067 928.257 nM -0.452793534806418 0.323087269651839 no 2301 0.325348709749197 3224 676295 SGTC_2365 9042475 200 µM -0.454030541312027 0.322713428501466 no 2302 0.324903422396762 3284 6464479 SGTC_1505 k297-0037 20.6 µM -0.454145628931577 0.322678656470126 no 2303 0.324862006813421 3193 4089396 SGTC_1757 st041620 31.8375 µM -0.456099334950239 0.322088609724673 no 2304 0.324159274196171 3256 5289815 SGTC_3129 9127257 49.47 µM -0.458625423035777 0.321326359958178 no 2305 0.323251588419724 3175 837894 SGTC_922 1866-0035 480 µM -0.459112286184941 0.321179534816487 no 2306 0.32307676713502 3186 3156169 SGTC_2043 5101342 149 µM -0.460139487392419 0.320869849611656 no 2307 0.322708051185666 3232 678451 SGTC_1500 4488-1866 171 µM -0.461045370341348 0.320596843353632 no 2308 0.322383027243004 3359 2900003 SGTC_2225 6654152 15.4 µM -0.462434984441284 0.320178243475534 no 2309 0.32188470807596 3262 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2685 mycophenolic acid 18.85 µM -0.462465430037541 0.320169074766956 no 2310 0.321873793788236 3230 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3334 9142812 21.919 µM -0.462935281563531 0.320027592639596 no 2311 0.321705378582583 3314 45283678 SGTC_372 0155-0182 15.9 µM -0.464105135984192 0.319675438722523 no 2312 0.321286211115302 3206 771486 SGTC_2088 5278280 127.392 µM -0.466124004051063 0.319068093908611 no 2313 0.320563371169548 3325 791502 SGTC_146 3448-8650 53.125 µM -0.471573357701497 0.31743116806298 no 2314 0.318615673555815 3238 2891488 YIL048W NEO1 SGTC_477 mead ethanolamide 10 µM -0.473478903506968 0.316859602430835 no 2315 0.317935774298756 3246 16061185 SGTC_1822 st052468 42 µM -0.473790658484247 0.316766133532863 no 2316 0.31782459835105 3281 2873678 SGTC_2692 st077426 47.7 µM -0.47459961925197 0.316523649316416 no 2317 0.317536188849126 3365 25238571 SGTC_3000 9075062 71.4286 µM -0.477958876656098 0.315517563670355 no 2318 0.316339737362924 3234 17057871 SGTC_2015 5119600 184 µM -0.478170105464869 0.315454346964688 no 2319 0.316264568988904 3372 2828786 SGTC_3048 9093155 49.47 µM -0.478433743279876 0.315375452832726 no 2320 0.316170760875652 3341 25236002 SGTC_1959 st077091 55.8 µM -0.480098429317081 0.314877486766051 no 2321 0.315578702518969 3211 821356 YKL052C ASK1 SGTC_2916 7875993 68.79 µM -0.480295049925828 0.31481869282973 no 2322 0.315508804099395 3383 1299250 SGTC_216 k038-0035 28.382 µM -0.485622011522526 0.313227602927423 no 2323 0.313617593585195 3317 4444231 YPR107C YTH1 SGTC_2781 5567276 71.43 µM -0.486133558513903 0.313074993095164 no 2324 0.313436237522079 3372 2853274 SGTC_2027 5150920 200 µM -0.487382518925325 0.31270252524227 no 2325 0.312993639686893 3275 786715 SGTC_277 nystatin 15.5 µM -0.488431926864742 0.312389716162472 no 2326 0.312621966060916 3201 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_699 0375-0592 111 µM -0.489133542488008 0.31218065290355 no 2327 0.3123735778524 3390 762578 SGTC_2904 7225135 42.03 µM -0.489884021713777 0.311957096487342 no 2328 0.312107985135679 3377 4446116 SGTC_1246 0422-0085 105 µM -0.490804648971713 0.311682950128313 no 2329 0.311782310805067 3391 264295 SGTC_109 0132-0036 33.701 µM -0.491199907446172 0.311565281217217 no 2330 0.311642532202605 3283 67274 A color developer. SGTC_478 N-arachidonylglycine 10 µM -0.492653155457431 0.311132813081924 no 2331 0.311128841220762 3306 5283389 SGTC_1526 st051518 75 µM -0.495041653024127 0.310422592920735 no 2332 0.310285359296933 3259 673993 SGTC_2193 5925765 200 µM -0.495187505924107 0.310379246389846 no 2333 0.310233884576481 3358 877370 SGTC_1089 terbinafine 2.25 µM -0.495334897327629 0.310335445301086 no 2334 0.310181870660671 3371 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2203 7227154 166.4 µM -0.496033453464098 0.310127888245608 no 2335 0.309935404281041 3352 896304 SGTC_1317 1273-0028 910 nM -0.496729196099535 0.30992122725687 no 2336 0.309690015440401 3274 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2756 carbadox 75.1 µM -0.497507898884134 0.309689995284014 no 2337 0.309415467069177 3289 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_387 norethindrone acetate 66.7 µM -0.498653568625358 0.309349931167576 no 2338 0.309011729983202 3312 541197 SGTC_1545 lovastatin 49.4 µM -0.498971490362582 0.309255592774456 no 2339 0.30889973436616 3344 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1417 3966-0327 90.4 µM -0.500069741418977 0.308929800409588 no 2340 0.30851298561864 3334 651118 SGTC_11 0438-0307 1.3 µM -0.500751733010832 0.308727565578237 no 2341 0.308272929354828 3383 4011476 SGTC_1361 1608-0041 5.61 µM -0.501501475203429 0.308505307195888 no 2342 0.308009119943191 3309 X1361 SGTC_3061 glucosamine 200 µM -0.501912690570765 0.308383433660836 no 2343 0.307864469000509 3363 91431 and experimental redox chemotherapeutic SGTC_185 k048-0037 25.491 µM -0.502789378767185 0.308123676594282 no 2344 0.307556180955597 3388 6827589 SGTC_2408 sulbentine 18.36 µM -0.5030853043601 0.308036017429358 no 2345 0.307452149165469 3230 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_107 0358-0022 2.6945 µM -0.503334716941526 0.307962144865996 no 2346 0.307364480917045 3339 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1438 4092-1045 4 µM -0.503418905702192 0.307937211073762 no 2347 0.307334891144248 3290 1351342 SGTC_710 3448-4187 58 µM -0.504995022836677 0.30747058360224 no 2348 0.306781165880592 3373 3946412 SGTC_2576 guaiol 23.12 µM -0.505073710904806 0.307447295257039 no 2349 0.306753532537059 3310 227829 SGTC_3088 9117578 49.47 µM -0.505812189985363 0.307228774469438 no 2350 0.306494250105623 3406 678341 SGTC_310 1273-0058 1.06 µM -0.50586065674268 0.307214435231237 no 2351 0.306477236652864 3386 2734232 SGTC_2242 6630449 61.2675 µM -0.507584503603774 0.30670461457574 no 2352 0.305872380232745 3386 691249 YDR170C SEC7 SGTC_1870 st057514 26.5 µM -0.509119323728848 0.306251012246875 no 2353 0.305334293892649 3261 5393161 SGTC_205 1486-1330 71.903 µM -0.509335210955714 0.306187232508565 no 2354 0.305258640564451 3339 4118834 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.509979023461097 0.30599706534068 no 2355 0.305033078848042 3366 3256 An antibiotic and ribosome inhibitor. SGTC_3300 9124615 50.48 µM -0.511675094683257 0.305496335914561 no 2356 0.304439209676164 3440 24824903 SGTC_1225 1216-0074 20.6 µM -0.511917913809315 0.305424678398279 no 2357 0.30435423014114 3317 4241466 SGTC_3239 9133757 49.47 µM -0.512157408356595 0.305354009288706 no 2358 0.304270424457309 3362 17036923 SGTC_897 1000-0139 31.4 µM -0.512169015029291 0.305350584621618 no 2359 0.304266363226615 3400 6151020 SGTC_1459 k035-0031 35.7 µM -0.513199290815267 0.305046659151735 no 2360 0.303905960996854 3270 3877128 YMR208W ERG12 SGTC_1256 0570-0116 285 µM -0.514031830530431 0.304801162872418 no 2361 0.303614868259906 3318 410638 SGTC_186 3455-3465 67.277 µM -0.514279794878728 0.304728061024393 no 2362 0.303528193012671 3339 755278 SGTC_3052 9092717 49.47 µM -0.517921952683216 0.303655223583198 no 2363 0.302256362368372 3416 25237534 SGTC_2941 9056145 11.23 µM -0.51812246638892 0.303596209071077 no 2364 0.302186413077542 3376 2119517 SGTC_470 aa-861 153 µM -0.518406219529086 0.303512704563776 no 2365 0.302087438093165 3340 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_491 tetrandrine 80.3 µM -0.520133119300151 0.303004723909408 no 2366 0.301485398073302 3380 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3102 9121669 49.47 µM -0.520261704069606 0.302966914947814 no 2367 0.301440591844566 3326 41905072 SGTC_1219 1469-0211 33.1 µM -0.520460285632428 0.302908528334412 no 2368 0.301371400650948 3374 6822282 SGTC_623 k072-0108 16.9 µM -0.520566222621445 0.302877382981399 no 2369 0.301334492260201 3363 5382803 SGTC_2931 9014674 55.67 µM -0.521688826350449 0.302547426908967 no 2370 0.300943502838785 3276 2996810 SGTC_961 1252-1571 372 µM -0.523875308929067 0.301905238188766 no 2371 0.3001826346157 3454 6813498 SGTC_3346 9158254 43.5805 µM -0.524010579868159 0.301865528076376 no 2372 0.300135590627405 3364 17639500 SGTC_1440 4100-1550 40 µM -0.524156878436624 0.30182258333726 no 2373 0.300084715247476 3372 742806 SGTC_1223 0764-0573 147 µM -0.524676646764306 0.30167003184065 no 2374 0.299903997180332 3381 1609797 SGTC_2582 agaric acid 100 µM -0.525119913657338 0.301539960841497 no 2375 0.299749916800292 3395 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_269 exalamide 29 µM -0.526066738237532 0.301262211828307 no 2376 0.299420918986327 3320 3316 A derivative of salicylamide. SGTC_2985 9022375 71.43 µM -0.527351620080235 0.300885478816027 no 2377 0.298974716801153 3475 4939335 SGTC_1672 st016598 6.51 µM -0.528827708019185 0.300452945785977 no 2378 0.29846248736748 3333 4665860 YNL267W PIK1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.530037032847169 0.300098790903913 no 2379 0.298043127428125 3422 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1420 4'-methoxyflavone 42 µM -0.534717978364066 0.298729743558456 no 2380 0.29642244383485 3417 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2214 7179297 48.276 µM -0.535763889040569 0.298424232033588 no 2381 0.296060871090195 3405 769744 SGTC_2629 bisabolol 100 µM -0.536198075281186 0.29829744758863 no 2382 0.295910831795792 3448 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_913 3487-1245 167 µM -0.53844734562658 0.297641042908874 no 2383 0.295134123682719 3316 4016153 SGTC_2091 4-phenylthiadiazole 200 µM -0.538938285076423 0.297497859710853 no 2384 0.294964719531875 3348 270010 SGTC_2854 9024559 71.43 µM -0.539724893065078 0.29726850994752 no 2385 0.294693385084562 3384 3163529 SGTC_2194 5927483 104.545 µM -0.541888760886732 0.296638012454333 no 2386 0.293947569865241 3409 760979 SGTC_3290 9121031 71.43 µM -0.542153434387958 0.296560935209069 no 2387 0.293856405414634 3352 17014854 SGTC_2257 7960413 200 µM -0.543571496742615 0.296148128659169 no 2388 0.293368189254326 3382 2974689 YIL048W NEO1 SGTC_2975 9084847 53.72 µM -0.544283274003108 0.29594102540918 no 2389 0.29312327749547 3394 27211724 SGTC_1489 4065-0444 182 µM -0.544529729969516 0.295869330512483 no 2390 0.293038497841232 3431 2877968 SGTC_2502 avocadyne acetate 18.59 µM -0.549970250513673 0.294288700065508 no 2391 0.291169889275338 3388 3952079 SGTC_1499 4480-0877 67.3 µM -0.550176220604293 0.29422893641961 no 2392 0.291099255943855 3409 2861909 SGTC_1647 st011722 22.4 µM -0.551726181839868 0.293779384401483 no 2393 0.290567984553136 3462 2854783 SGTC_3085 9117376 49.47 µM -0.552260194159792 0.293624572676951 no 2394 0.290385049328134 3445 16480349 SGTC_2375 9072683 200 µM -0.552266338554532 0.293622791618843 no 2395 0.290382944772486 3501 16798029 SGTC_2935 9038016 29.96 µM -0.555351940880983 0.292729009522411 no 2396 0.289326978979214 3476 6463195 SGTC_199 4063-0024 41.6 µM -0.557064306887201 0.29223354772777 no 2397 0.288741746618359 3471 306215 SGTC_1114 scopoletin 1.73284 µM -0.558565429230464 0.291799529059401 no 2398 0.288229169576776 3479 5280460 A coumarin with genotoxic properties. SGTC_2396 5342950 42.78 µM -0.558663192278102 0.291771273303318 no 2399 0.288195802050426 3415 1886677 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.560280827214029 0.291303925003235 no 2400 0.287643951442152 3436 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3315 9136395 68.55 µM -0.560678504188728 0.291189086314877 no 2401 0.287508361826908 3530 16876844 SGTC_526 4469-0568 170 µM -0.567611405793519 0.28919045101744 no 2402 0.285149430323067 3469 2901964 SGTC_3230 9131665 49.47 µM -0.568762027125244 0.288859371862602 no 2403 0.284758823799005 3412 15943720 SGTC_209 4077-0173 175.592 µM -0.570442993954629 0.288376012329875 no 2404 0.284188637996056 3419 15993494 SGTC_718 1130-0073 349 µM -0.570873526708686 0.288252274638054 no 2405 0.284042688675601 3551 6740020 SGTC_3262 9137218 49.47 µM -0.571258170427279 0.288141746914472 no 2406 0.283912325937158 3371 17650664 SGTC_1953 st076800 12.1 µM -0.572139933781812 0.287888446900022 no 2407 0.283613588438645 3401 297591 SGTC_2127 5253358 187.912 µM -0.572556481399738 0.287768823805088 no 2408 0.283472516352302 3393 20612 SGTC_1780 st038448 24.544 µM -0.572586699444008 0.287760146776918 no 2409 0.283462283722731 3508 728868 YDL195W SEC31 SGTC_1558 st069300 45.6 µM -0.575258339501649 0.286993481708673 no 2410 0.282558296202909 3467 24208000 SGTC_720 r052-1644 49.9 µM -0.576839346617256 0.286540245410862 no 2411 0.282023993466567 3468 1422863 YOR257W CDC31 SGTC_1650 st011916 45.8 µM -0.577796372165764 0.286266054542356 no 2412 0.281700802436253 3498 242528 SGTC_1616 st002734 56.1 µM -0.578568689152946 0.28604487414226 no 2413 0.281440118421669 3394 4026101 SGTC_2867 9039098 71.43 µM -0.579076924153297 0.285899367315499 no 2414 0.281268634848522 3473 6463460 SGTC_319 1348-1596 45.5 µM -0.579290515779694 0.28583822689543 no 2415 0.281196581955195 3535 5380505 SGTC_3015 9080845 49.47 µM -0.581622655142269 0.285171058894334 no 2416 0.280410439749469 3509 5296973 SGTC_2523 spermine 47.74 µM -0.582958256753617 0.284789310472486 no 2417 0.279960700735907 3463 1103 A DNA binding polyamine. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.583270158586644 0.28470019624665 no 2418 0.279855723988213 3466 521171 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.58541129837134 0.284088805627421 no 2419 0.279135596780762 3477 65057 A dermal irritant. YDR527W RBA50 SGTC_1201 1889-3372 45.9 µM -0.585857795265148 0.283961390088481 no 2420 0.278985540565296 3427 5392199 SGTC_2397 5161689 200 µM -0.586628058381881 0.283741646610938 no 2421 0.278726767046987 3559 2259942 SGTC_2644 guaiazulene 100 µM -0.586782100748177 0.283697710614491 no 2422 0.278675029813213 3487 3515 A coloring agent. SGTC_651 3253-0966 34.4 µM -0.586889590630217 0.283667054257723 no 2423 0.278638930637409 3458 781462 SGTC_3330 9141424 71.43 µM -0.586889710332682 0.283667020119195 no 2424 0.278638890438054 3497 27261020 SGTC_3137 9097352 49.47 µM -0.587172681093555 0.283586323812433 no 2425 0.278543869028867 3616 44120435 SGTC_772 k072-0172 35.3 µM -0.587471692216835 0.283501065141858 no 2426 0.278443478430291 3421 5861980 SGTC_2612 dictamnine 15.46 µM -0.589718875013061 0.282860707061934 no 2427 0.277689569374218 3442 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2131 toluylene red 5.2905 µM -0.590284445812955 0.282699651274007 no 2428 0.277499982764224 3431 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2738 aclarubicin 5.55 µM -0.591005760158753 0.282494308854517 no 2429 0.277258280740159 3412 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2595 hexamethylquercetagetin 100 µM -0.59132687992017 0.282402916158578 no 2430 0.277150711278152 3425 386331 SGTC_3259 9138485 49.47 µM -0.591793192291881 0.282270226062619 no 2431 0.276994541215627 3654 17646153 SGTC_3336 9143619 71.43 µM -0.592055739033022 0.282195531078087 no 2432 0.276906632117385 3541 45595730 SGTC_1427 4048-4900 550 nM -0.594122722823712 0.281607803284089 no 2433 0.276215016973 3512 24132586 SGTC_2926 9010726 65.15 µM -0.597843577702609 0.280551302662403 no 2434 0.274972155220918 3500 2994293 SGTC_1746 st038117 42 µM -0.601645061395273 0.279473893095103 no 2435 0.273705213512403 3495 2898218 SGTC_2519 cryptotanshinone 88.04 µM -0.602520079616433 0.27922618181268 no 2436 0.273414000661579 3529 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2930 9013230 14.89 µM -0.602676916537036 0.279181793703281 no 2437 0.273361820335206 3521 2995857 SGTC_2260 7964312 200 µM -0.602966376834355 0.279099879429004 no 2438 0.273265528585618 3569 231951 SGTC_2492 derrusnin 100 µM -0.602973523104671 0.279097857256143 no 2439 0.273263151522663 3478 1715307 Part of coumarin class of compounds. SGTC_2782 7736369 71.43 µM -0.603613764309923 0.27891671776675 no 2440 0.273050229749902 3515 2950836 YOL077C BRX1 SGTC_226 1,3-diallylurea 8.28947 mM -0.603953790870305 0.278820539412178 no 2441 0.272937182285212 3476 74537 YKL182W FAS1 SGTC_643 k048-0106 28.4 µM -0.604127767700334 0.278771335365916 no 2442 0.272879349781587 3532 6763920 SGTC_2966 9084041 48.03 µM -0.607280288416357 0.277880473830232 no 2443 0.271832458718297 3392 17741380 SGTC_2180 6301957 200 µM -0.608221183488287 0.277614858597806 no 2444 0.271520393377538 3518 845462 SGTC_1025 k007-0731 70 µM -0.610205165458324 0.277055186184403 no 2445 0.270862954223881 3465 6256118 SGTC_353 1988-1175 58.3 µM -0.61224429275552 0.276480533593116 no 2446 0.270188070291979 3411 2788357 SGTC_792 4534-1957 155 µM -0.614169490470958 0.275938524758904 no 2447 0.269551666041593 3475 1717904 SGTC_850 0388-0143 75.9 µM -0.615519040862554 0.275558891697523 no 2448 0.269105999299898 3504 67273 SGTC_2332 7982454 138.89 µM -0.617565462474996 0.274983716911417 no 2449 0.268430908515959 3535 2981748 SGTC_679 0422-0091 41.4 µM -0.618554544137691 0.274705934164706 no 2450 0.268104927463967 3565 627384 YHR062C RPP1 SGTC_1010 4112-3296 15.2 µM -0.618992421940397 0.274583000759644 no 2451 0.267960675570383 3596 704384 SGTC_3353 9151644 39.2805 µM -0.620835675247989 0.27406580847062 no 2452 0.267353873865492 3551 4909158 SGTC_3208 9114115 49.47 µM -0.621204158007502 0.27396247488372 no 2453 0.267232651993438 3493 650895 SGTC_3185 9108267 49.47 µM -0.621656667019651 0.273835604172807 no 2454 0.267083825483896 3540 4910486 SGTC_759 3486-0358 89.3 µM -0.626463366908094 0.272489737698676 no 2455 0.265505528856735 3598 875103 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.626924924236008 0.272360675610245 no 2456 0.26535422426749 3560 5106787 A p450 inhibitor. SGTC_2212 7123476 200 µM -0.627782908428767 0.272120844132711 no 2457 0.265073082049264 3516 1085715 SGTC_564 3555-0129 330 µM -0.628619750419271 0.27188702369758 no 2458 0.264799013496985 3491 563260 SGTC_3086 9117350 49.47 µM -0.628998035980831 0.271781360458468 no 2459 0.26467517100709 3495 2679265 SGTC_3247 9135149 49.47 µM -0.6297814199907 0.271562609568291 no 2460 0.264418801767787 3541 8934436 YOR116C RPO31 SGTC_3187 9109394 49.47 µM -0.630649591169569 0.271320285319123 no 2461 0.264134832914102 3512 17098090 SGTC_128 0906-2981 13.371 µM -0.631546630614832 0.271070016600446 no 2462 0.263841584854811 3560 6740226 SGTC_3278 9139605 49.47 µM -0.632407224923281 0.270830024126226 no 2463 0.263560407047189 3614 7958859 SGTC_2787 5284540 71.43 µM -0.632847966843521 0.270707156253516 no 2464 0.263416464806372 3559 736958 SGTC_1514 1189-1591 158 µM -0.632973040718378 0.270672293842225 no 2465 0.263375624145502 3597 767698 YMR146C TIF34 SGTC_2163 5671233 125 µM -0.633077674377196 0.270643130547995 no 2466 0.263341460359277 3637 701023 SGTC_272 doxorubicin 8.13 µM -0.633739270833554 0.270458767981513 no 2467 0.263125495847509 3584 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.638063419586291 0.269255334655379 no 2468 0.261716198784565 3584 616764 SGTC_100 0086-0128 49.5915 µM -0.638969002892189 0.269003646617077 no 2469 0.261421548480414 3557 93297 SGTC_141 0443-0274 32.331 µM -0.639274821858528 0.2689186772801 no 2470 0.261322082431533 3676 1627241 SGTC_1145 3546-0597 10.2 µM -0.639754685385304 0.268785378230242 no 2471 0.261166048476298 3533 875334 SGTC_3118 9124250 49.47 µM -0.640063932690015 0.268699491453862 no 2472 0.261065518013075 3493 1504786 SGTC_2507 purpurin 79.67 µM -0.640678589392953 0.268528824745307 no 2473 0.260865763797861 3523 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2666 tannic acid 100 µM -0.641372999234895 0.268336079210914 no 2474 0.260640185626448 3600 16134267 A thiamine antagonist. SGTC_2345 9052315 157.45 µM -0.642915885156748 0.267908073595457 no 2475 0.260139340670951 3561 6469265 SGTC_3333 9141820 12.094 µM -0.64296448851189 0.267894596327504 no 2476 0.260123571324002 3557 1939433 SGTC_1031 k035-0009 16 µM -0.643161335839824 0.267840015847637 no 2477 0.260059709295314 3608 5180959 SGTC_2402 5553605 200 µM -0.644351933550631 0.26751001450933 no 2478 0.259673623015297 3625 6758546 SGTC_293 4049-0273 38.5 µM -0.644580089630559 0.267446799259489 no 2479 0.259599670500055 3522 1380311 SGTC_694 1315-0438 43.2 µM -0.64466445569223 0.267423425846402 no 2480 0.25957232757709 3533 6793154 SGTC_1857 st056007 79.3 µM -0.645162566475658 0.267285446462634 no 2481 0.259410920879578 3607 619834 SGTC_1723 st034307 2.5525 µM -0.645706443448147 0.2671348306329 no 2482 0.259234743438117 3597 867466 SGTC_3168 9103419 49.47 µM -0.646208576127102 0.266995813097871 no 2483 0.259072143097175 3541 16649256 SGTC_3004 9076122 71.4286 µM -0.646717721026496 0.26685489151568 no 2484 0.25890732592536 3582 44782551 SGTC_2840 9008771 71.43 µM -0.647005509198583 0.266775253874652 no 2485 0.258814188957147 3553 2992978 SGTC_3338 9144300 39.5675 µM -0.647949975378058 0.266513982662926 no 2486 0.258508652957455 3554 4901274 SGTC_1995 st072814 61.1 µM -0.650568309400398 0.265790340487134 no 2487 0.25766259648496 3543 5769371 SGTC_2496 diffractaic acid 79.83 µM -0.655223204999753 0.264506307372446 no 2488 0.256162028044285 3668 94870 An apoptosis inducer which activates caspases. SGTC_1401 3807-4679 7.6 µM -0.655318703745885 0.264479997530924 no 2489 0.256131290508472 3592 3291456 SGTC_2371 9071574 200 µM -0.657124400300216 0.263982780098036 no 2490 0.255550465381206 3582 45596039 SGTC_1783 st039459 87.517 µM -0.657641765914345 0.263840405917373 no 2491 0.255384175088874 3652 729761 SGTC_391 gliotoxin 8.33 µM -0.658553127817569 0.263589702901375 no 2492 0.255091385155757 3644 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2014 4013930 200 µM -0.659455164020795 0.263341685001484 no 2493 0.254801764242753 3586 64556 SGTC_406 estrone 100 µM -0.660086642235801 0.263168128870642 no 2494 0.254599115108875 3627 5870 A steroid. SGTC_1654 st012436 41.8 µM -0.6601373500582 0.263154194814918 no 2495 0.254582846006818 3590 4323132 SGTC_1829 berberine 14.4 µM -0.661727903512475 0.262717316385395 no 2496 0.254072809269055 3637 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2460 5552655 174.22 µM -0.661732881483228 0.262715949665347 no 2497 0.254071213843926 3602 5401989 SGTC_814 3342-0569 96 µM -0.663022296682252 0.262362058545336 no 2498 0.253658137076541 3655 4346283 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.663366528371591 0.262267622493144 no 2499 0.2535479187709 3627 6708561 SGTC_3180 9109287 49.47 µM -0.663382432119275 0.262263259901545 no 2500 0.253542827215309 3605 18891271 SGTC_2483 5729050 27.16 µM -0.664109077839776 0.262063971792803 no 2501 0.25331025023169 3659 2865180 SGTC_489 paxilline 115 µM -0.664609802748502 0.261926689368864 no 2502 0.253150048860488 3611 105008 A toxic potassium channel blocker. SGTC_2113 5491891 107.031 µM -0.665686553748852 0.261631604354118 no 2503 0.252805734925359 3634 789979 SGTC_3084 9116877 49.47 µM -0.66605925235553 0.261529505577689 no 2504 0.252686614117518 3551 27241325 SGTC_1791 st048313 56.1 µM -0.666445211276798 0.261423795772327 no 2505 0.252563286251383 3571 1204976 SGTC_1332 1480-0653 17.5 µM -0.666527968891993 0.261401132249938 no 2506 0.252536846322749 3604 5749438 SGTC_1362 1611-0397 101 µM -0.667891614528384 0.261027837482965 no 2507 0.252101390226896 3616 27816 SGTC_2739 tacrine 100.86 µM -0.668396715460995 0.260889636891166 no 2508 0.251940195773033 3627 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2899 9053889 58.44 µM -0.668475335223713 0.260868129134758 no 2509 0.251915110493318 3592 6470052 SGTC_645 0845-0943 5.41 µM -0.668516000266833 0.260857004887174 no 2510 0.251902135978045 3596 1885106 SGTC_3149 9097855 49.47 µM -0.669103068285191 0.260696434932226 no 2511 0.251714866422965 3621 25236625 YMR079W SEC14 SGTC_324 1315-0088 19.6 µM -0.669422573547909 0.260609067893197 no 2512 0.251612977946398 3583 6787421 SGTC_1283 0922-0125 16.4 µM -0.669572144494586 0.260568173681906 no 2513 0.251565288079115 3624 3360884 SGTC_375 3970-0961 9.27 µM -0.670689816335911 0.260262695496288 no 2514 0.251209075829375 3591 2898222 SGTC_3073 9114972 49.47 µM -0.670982320346101 0.260182779794393 no 2515 0.251115896181615 3556 41905075 SGTC_2076 5212012 200 µM -0.67104703337798 0.260165101104957 no 2516 0.251095283763409 3530 604802 SGTC_1684 st024538 14.6195 µM -0.671397419526657 0.260069391293936 no 2517 0.250983694185955 3614 6732859 SGTC_842 0271-0008 11.1 µM -0.674204488474013 0.259303281519669 no 2518 0.250090658212445 3680 1221709 SGTC_1604 st002052 72.4 µM -0.674490759476595 0.259225217556897 no 2519 0.249999679274407 3665 6254834 YHR062C RPP1 SGTC_1276 0871-0068 94.2 µM -0.676037937406707 0.258803524021984 no 2520 0.249508279351802 3602 3414906 SGTC_2231 micatex 6.853 µM -0.676157955211228 0.258770827221976 no 2521 0.249470181901726 3652 20737 An antifungal of unknown mechanism. SGTC_152 4469-0003 551.229 µM -0.676267805380637 0.258740902294396 no 2522 0.249435314690617 3620 697280 SGTC_3233 9132340 49.47 µM -0.676731813404458 0.258614518917681 no 2523 0.249288063882487 3605 17682950 SGTC_2463 5473429 200 µM -0.677918977286792 0.25829131278975 no 2524 0.248911533387925 3610 5399405 SGTC_309 k408-0051 1.48 µM -0.679204700383917 0.257941510132237 no 2525 0.248504084740713 3631 3640463 SGTC_1877 wortmannin 25 µM -0.679492240342476 0.257863313677419 no 2526 0.24841301130839 3639 312145 A covalent inhibitor of PI 3-kinase. SGTC_595 3909-8003 73.7 µM -0.680463770457489 0.257599197211578 no 2527 0.248105427170632 3682 699517 SGTC_2853 9015042 58.44 µM -0.680959530491576 0.257464475936194 no 2528 0.247948549035724 3587 6457456 SGTC_1914 st062367 72.6 µM -0.682279952684449 0.257105833891687 no 2529 0.247530973480144 3643 978205 SGTC_968 1309-0633 340 µM -0.682668017996573 0.257000480252833 no 2530 0.247408321643069 3620 3761976 SGTC_1600 coumarin 106 71.1 µM -0.686916394091425 0.255848583211247 no 2531 0.246067707668122 3701 100336 A hepatotoxic, DNA x-linker. SGTC_2439 5492030 7.2 µM -0.687636754991181 0.255653533390648 no 2532 0.245840778202171 3631 5722370 SGTC_1103 duloxetine 36.1 µM -0.689706506997096 0.255093545634593 no 2533 0.245189386509017 3713 60835 A selective serotonin reuptake inhibitor. SGTC_1381 2324-0066 62.1 µM -0.690052602928521 0.254999969297082 no 2534 0.245080553948503 3661 10885928 SGTC_544 k015-0020 52.4 µM -0.692137255458789 0.25443670756094 no 2535 0.244425568683095 3671 3008304 SGTC_2601 securinine 100 µM -0.692793935164131 0.25425941142415 no 2536 0.244219439402878 3641 442872 A GABA receptor antagonist. SGTC_823 0417-1665 178 µM -0.693770232854701 0.253995941810377 no 2537 0.243913156567736 3694 3429856 SGTC_1487 3970-0795 2.82 µM -0.695092353201507 0.253639374877346 no 2538 0.243498713311264 3723 3765103 SGTC_1014 4130-3005 69.3 µM -0.695965704091095 0.25340398231261 no 2539 0.243225153976074 3690 743608 SGTC_2873 9040596 71.43 µM -0.696207744095643 0.25333876606689 no 2540 0.243149369299033 3659 6463863 SGTC_1804 st050076 49.1 µM -0.69705744893217 0.253109888005251 no 2541 0.242883420979594 3686 3895976 SGTC_3144 9087057 49.47 µM -0.697276605484187 0.253050873241966 no 2542 0.242814852917603 3596 17249618 SGTC_1816 st051957 91.6 µM -0.698373790921933 0.252755530586543 no 2543 0.242471731310422 3675 674121 SGTC_1230 0170-0365 3.77 µM -0.69893925934469 0.252603387528155 no 2544 0.242294995601915 3763 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2753 fluvastatin 17.09 µM -0.701331729938397 0.251960211548831 no 2545 0.24154800819857 3688 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_781 4335-2806 94.4 µM -0.702387685064813 0.251676610696963 no 2546 0.241218711590747 3783 845254 SGTC_1523 st012844 44.7 µM -0.703282604745359 0.251436391641892 no 2547 0.240939824557438 3751 4274103 SGTC_2244 6635614 200 µM -0.704539249324237 0.251099281138244 no 2548 0.240548508113526 3602 836499 SGTC_2167 5876490 200 µM -0.706926050507197 0.250459651024928 no 2549 0.239806217081775 3790 686534 SGTC_2972 9093619 59.92 µM -0.707471711158439 0.250313542785156 no 2550 0.239636693236551 3701 25236256 SGTC_427 1354-0053 47.3 µM -0.707555622827995 0.250291078276354 no 2551 0.239610629671478 3732 6813657 SGTC_757 1066-0008 322 µM -0.708070457613118 0.250153272093396 no 2552 0.239450752178201 3715 6842497 SGTC_2011 4012611 177 µM -0.708087310247492 0.250148761817432 no 2553 0.239445519723066 3712 2049887 SGTC_245 methotrexate 289.6 µM -0.708651397919184 0.249997819739846 no 2554 0.239270416162253 3677 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2037 5169046 200 µM -0.708747985912454 0.2499719789727 no 2555 0.239240440425481 3717 5718022 SGTC_2749 bexarotene 57.39 µM -0.709282691545052 0.249828951603701 no 2556 0.239074533579571 3706 82146 An retinoic acid receptor inhibitor. SGTC_289 k017-0060 526 µM -0.709393690954067 0.249799266034318 no 2557 0.239040100903171 3676 5512909 SGTC_2602 kawain 100 µM -0.710592017405871 0.249478906103074 no 2558 0.238668545588142 3667 5369129 SGTC_2347 9049783 174.81 µM -0.712946450411335 0.24885010972089 no 2559 0.237939447082572 3682 6467988 YPL169C MEX67 SGTC_2606 farnesol 9.78 µM -0.714476158024506 0.24844202462061 no 2560 0.237466396936614 3723 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1134 3477-0009 42.5 µM -0.714518139531067 0.248430830107286 no 2561 0.237453421765976 3726 3973534 SGTC_2995 9067767 71.4286 µM -0.715362985346567 0.248205606212294 no 2562 0.23719238909068 3698 11673567 SGTC_1279 0874-0590 65.2 µM -0.71540734478451 0.24819378362565 no 2563 0.237178687677332 3725 3523074 SGTC_1560 lithocholic acid 53.1 µM -0.715511664592092 0.248165981707594 no 2564 0.237146467864495 3633 9903 A bile acid which acts as a detergent. SGTC_3332 9141069 11.198 µM -0.715646398732657 0.248130076626917 no 2565 0.237104857957045 3654 17332883 SGTC_2949 9072542 2.23 µM -0.715823810103649 0.248082802787652 no 2566 0.237050074171708 3744 16457352 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.717470846579645 0.247644155421625 no 2567 0.23654180936131 3629 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_646 4092-0839 27.3 µM -0.719818164394134 0.247019722058802 no 2568 0.235818479763953 3752 877796 SGTC_813 k007-0158 173 µM -0.720831827577978 0.246750328100571 no 2569 0.235506495310026 3730 6523916 SGTC_2346 9031566 143.75 µM -0.721536323402841 0.246563192018156 no 2570 0.235289800355199 3700 4771086 SGTC_989 1501-0895 10.3 µM -0.721904088504685 0.24646553233934 no 2571 0.235176723710506 3688 2830112 SGTC_1984 st072354 53.1 µM -0.722823301618474 0.246221526831733 no 2572 0.234894224773167 3646 5762938 SGTC_2024 5144227 134 µM -0.72282541317857 0.246220966466373 no 2573 0.234893576049868 3750 3475211 SGTC_202 3594-0513 34.79 µM -0.723150397036295 0.246134730472859 no 2574 0.234793744803739 3694 708429 SGTC_1128 3448-9350 235 µM -0.723282502276247 0.246099680358065 no 2575 0.234753170322535 3754 619386 SGTC_3120 9124077 49.47 µM -0.727511068529162 0.244979174362603 no 2576 0.233456468664843 3772 18774327 YGL155W CDC43 SGTC_2511 berberine 10.47 µM -0.728549796386539 0.24470434776051 no 2577 0.233138548810797 3715 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1840 st055363 71 µM -0.728921993229644 0.24460591233783 no 2578 0.233024690325031 3710 676033 SGTC_3060 1327-0027 12.5 µM -0.729772739430906 0.244380994397892 no 2579 0.232764555121223 3662 16000455 YPR107C YTH1 SGTC_1606 st000094 49.2 µM -0.730255978038512 0.24425328675458 no 2580 0.23261686570591 3733 1242210 SGTC_729 4092-0585 94.1 µM -0.730995828181624 0.244057832951865 no 2581 0.232390850561567 3716 2169061 SGTC_2707 st078556 66.6 µM -0.732163845463781 0.243749437639764 no 2582 0.23203428437785 3708 17250899 SGTC_2607 solasodine 47.35 µM -0.7321790966438 0.243745412214079 no 2583 0.232029630593098 3758 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2486 5283202 22.39 µM -0.73336413944298 0.243432739502596 no 2584 0.231668182484012 3756 1377751 SGTC_1973 st070275 50.2 µM -0.733621524753649 0.243364857225016 no 2585 0.231589719276283 3650 17118334 SGTC_933 2914-0560 114 µM -0.73475225247032 0.243066762614883 no 2586 0.231245195553347 3745 463887 SGTC_1631 benzylvanillin 81.9 µM -0.735615936742119 0.242839201961814 no 2587 0.230982230564281 3765 75506 SGTC_2361 9034121 116 µM -0.73669205684989 0.242555830810594 no 2588 0.230654819175451 3749 6496917 SGTC_81 0411-0046 9.971 µM -0.741153358734921 0.241382963395969 no 2589 0.229300229843745 3652 12925265 SGTC_2910 7948405 25.97 µM -0.741410284454263 0.241315512090343 no 2590 0.229222355300694 3677 2971328 SGTC_675 1309-0189 238 µM -0.741815782746694 0.241209076523083 no 2591 0.229099478383587 3763 4246530 SGTC_974 1326-0144 138 µM -0.744092075329238 0.240612067056239 no 2592 0.228410386625477 3796 5411856 SGTC_497 capsazepine 133 µM -0.744200889361571 0.240583548262909 no 2593 0.228377475038855 3739 2733484 A calcium channel blocker. SGTC_3181 9108277 49.47 µM -0.746564735418843 0.239964468310572 no 2594 0.227663170889138 3699 17097298 SGTC_1292 0kpi-0043 232 µM -0.746910114315883 0.239874088026583 no 2595 0.227558910121668 3770 3333905 SGTC_1282 0886-0010 32.4 µM -0.747680898015866 0.23967245289927 no 2596 0.22732632786408 3821 2836211 YNL267W PIK1 SGTC_464 bw-b 70c 158 µM -0.750875146730845 0.238837832087364 no 2597 0.226363899440667 3810 5353454 SGTC_63 0099-0242 26.702 µM -0.751089203266315 0.238781958444202 no 2598 0.226299486502448 3804 3898502 YLR359W ADE13 SGTC_2019 4016004 108 µM -0.751262269396894 0.238736789460782 no 2599 0.226247415784669 3767 45595336 SGTC_1157 4092-0394 27.6 µM -0.751516118629674 0.238670545141458 no 2600 0.226171051956999 3838 3659885 SGTC_2520 obtusaquinone 4.71 µM -0.752348814922163 0.238453315924998 no 2601 0.225920659574413 3785 5967872 SGTC_3298 9116858 71.43 µM -0.753443826676852 0.238167820149536 no 2602 0.22559162745043 3786 2506942 SGTC_2953 9074162 66.49 µM -0.754838832582736 0.237804380170283 no 2603 0.225172845329392 3687 16451992 SGTC_175 3793-3120 23.7 µM -0.75716378592664 0.23719933809789 no 2604 0.224475871661263 3779 5322297 SGTC_3242 9133940 49.47 µM -0.762121158057468 0.235912068197856 no 2605 0.222993848019896 3792 17248444 SGTC_1504 k297-0033 30 µM -0.762657275444101 0.23577308687515 no 2606 0.222833908467732 3691 4388117 SGTC_1315 1237-0019 3.69 µM -0.763195633857768 0.235633570037164 no 2607 0.222673366143705 3759 825140 SGTC_2988 9073640 71.4286 µM -0.767997010296093 0.23439129839023 no 2608 0.22124448054356 3801 9102229 SGTC_2253 7938677 135.83 µM -0.768212512589037 0.234335626077254 no 2609 0.221180470464689 3819 2301972 SGTC_1022 4477-0945 21.3 µM -0.769177439483342 0.234086439091215 no 2610 0.220893990727272 3755 4648966 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.769260293112692 0.23406504944713 no 2611 0.220869401997866 3809 229346 A bile salt which induces apoptosis. SGTC_2490 carminic acid 95.39 µM -0.770630475129824 0.233711477770851 no 2612 0.220462996121023 3701 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2069 5228469 200 µM -0.771360799151846 0.2335231407087 no 2613 0.220246551954467 3752 2835210 SGTC_2918 7977171 22.06 µM -0.773911690983953 0.232865973786708 no 2614 0.21949150775565 3725 2236483 SGTC_1190 1486-1332 13 µM -0.775264097069769 0.232517980840252 no 2615 0.219091809938548 3792 4150046 SGTC_2307 7538926 6.34 µM -0.780029297522168 0.231294135701731 no 2616 0.217686815276119 3828 96582 SGTC_2044 5102272 200 µM -0.780804224532156 0.231095451636879 no 2617 0.217458824507226 3797 592666 SGTC_2112 5488546 200 µM -0.78173102468951 0.230857953842147 no 2618 0.217186332341364 3789 600757 SGTC_3132 9126706 49.47 µM -0.782491727258491 0.230663121386212 no 2619 0.216962822645659 3823 850858 SGTC_455 paf C-16 10 µM -0.782598324597429 0.230635826832114 no 2620 0.216931512829735 3775 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3041 9091929 49.47 µM -0.783948386222692 0.230290295886701 no 2621 0.216535198213393 3826 25236887 SGTC_2693 st077581 40.7 µM -0.785052652997342 0.23000788834405 no 2622 0.216211349084437 3859 25238761 SGTC_2413 inermin 26.06 µM -0.786603762355934 0.22961153184542 no 2623 0.215756928070592 3892 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2182 6325192 200 µM -0.787795469206149 0.229307273912822 no 2624 0.215408175845573 3727 736248 SGTC_1795 st049545 62.3 µM -0.790328198879452 0.228661387052514 no 2625 0.214668061274998 3752 5291882 SGTC_2670 beta-carotene 100 µM -0.79145593821766 0.228374124399973 no 2626 0.214338989253509 3728 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2372 9071633 200 µM -0.793207200644176 0.227928437494136 no 2627 0.213828556473208 3877 21321366 SGTC_2751 anetholtrithion 17.25 µM -0.793218823565489 0.227925481158438 no 2628 0.213825171157566 3825 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3155 9099265 49.47 µM -0.79674383582678 0.227029876415575 no 2629 0.212799909830202 3839 25236499 SGTC_2641 levomentholum 100 µM -0.798518489939553 0.226579739630463 no 2630 0.212284833810968 3790 16666 SGTC_1961 st076550 68.7 µM -0.798856847000744 0.226493973390031 no 2631 0.212186711752218 3840 1579337 SGTC_1825 st052143 62.6 µM -0.79937178707351 0.226363482335112 no 2632 0.212037432288104 3831 674173 SGTC_825 1988-2224 89.6 µM -0.802093930926379 0.225674369351261 no 2633 0.211249312707559 3824 1180859 SGTC_67 0335-0847 266 µM -0.802126564864863 0.225666115248786 no 2634 0.211239874898646 4002 4552207 YOR254C SEC63 SGTC_2115 tiliquinol 12.7705 µM -0.802945465711316 0.225459046576271 no 2635 0.211003127809045 3835 71208 A bioactive hydroxyquinoline. SGTC_2796 7949634 45.45 µM -0.80422828328051 0.225134887443039 no 2636 0.210632573627226 3810 2971588 SGTC_3081 9117243 49.47 µM -0.804278972565109 0.225122084036344 no 2637 0.210617939386226 3871 45595589 SGTC_2232 chlorophetanol 41.5365 µM -0.804991211393682 0.224942226063458 no 2638 0.210412375692248 3913 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2800 7887935 81.82 µM -0.805714283507511 0.224759715761366 no 2639 0.210203805863566 3864 2961002 SGTC_1747 st037496 66.6 µM -0.806193955464963 0.224638688325977 no 2640 0.210065511720213 3848 723305 SGTC_1911 st060208 74.3 µM -0.807072544377965 0.224417104880148 no 2641 0.209812344563724 3903 688783 SGTC_1310 1188-0297 994 nM -0.807529857075676 0.224301817994772 no 2642 0.209680640001868 3755 1588352 SGTC_88 0180-0332 8.668 µM -0.809549734229636 0.223793016636635 no 2643 0.209099503843569 3911 3101745 SGTC_1229 0139-0193 12.2 µM -0.81028931543515 0.223606882429547 no 2644 0.208886957356291 3870 3090752 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.811012557072666 0.223424945659892 no 2645 0.208679229805211 3851 689007 SGTC_3165 9101544 49.47 µM -0.813546779296388 0.222788108372097 no 2646 0.2079523186229 3867 5002184 SGTC_590 k048-0076 22.4 µM -0.815720771652071 0.222242620279415 no 2647 0.207329928030375 3838 6832814 SGTC_619 1652-1634 108 µM -0.817289223730776 0.221849545257597 no 2648 0.206881581830367 3819 5400454 SGTC_3271 9137798 49.47 µM -0.818818080028357 0.221466775925494 no 2649 0.206445106977474 3763 6498326 SGTC_2141 5621638 7.665 µM -0.823175626743351 0.220377880669528 no 2650 0.205204063535517 3908 2856238 SGTC_2366 9070441 60.58 µM -0.823301914267759 0.220346368857406 no 2651 0.205168162660211 3870 6837235 SGTC_1940 st075990 51.1 µM -0.823559742353073 0.220282042493277 no 2652 0.205094879171424 3944 1084979 SGTC_2472 5377652 49.4 µM -0.825199527048459 0.219873179378956 no 2653 0.204629160953464 3937 1610903 SGTC_3125 9127534 49.47 µM -0.826289984277588 0.219601526599935 no 2654 0.204319806841607 3717 1639235 SGTC_1954 st077032 68.9 µM -0.826562215033329 0.21953373903363 no 2655 0.204242620579435 3822 698907 SGTC_3045 9092950 49.47 µM -0.828543127062533 0.219040838667598 no 2656 0.203681490728527 3830 44120432 SGTC_2788 5282734 71.43 µM -0.831393428617057 0.218332730388919 no 2657 0.202875705076579 3944 743706 SGTC_2986 9022445 71.43 µM -0.831894058962803 0.218208493703915 no 2658 0.202734372784214 3857 6459286 SGTC_212 3807-4682 38.772 µM -0.832604087814204 0.218032362455609 no 2659 0.20253402639686 3959 3125501 YBL034C STU1 SGTC_2809 7964133 12.99 µM -0.833664047396803 0.217769579215503 no 2660 0.202235161589474 3908 1253665 SGTC_553 k007-0256 45.7 µM -0.834718189477538 0.217508419532603 no 2661 0.201938198883102 3927 6287000 SGTC_1590 st077108 57.8 µM -0.835185996697955 0.217392580016951 no 2662 0.201806496427497 3865 5489485 SGTC_3071 9117417 49.47 µM -0.835312203603648 0.217361334470736 no 2663 0.20177097402315 3817 45595590 YGL055W OLE1 SGTC_2745 rifampicin 24.3 µM -0.836197314261701 0.217142276977245 no 2664 0.201521954543992 3864 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3064 1327-0027 10 µM -0.83747136959801 0.216827182960677 no 2665 0.201163831774595 3761 16000455 YPR107C YTH1 SGTC_2541 muurolladie-3-one 83.07 µM -0.84311144874309 0.215435481586779 no 2666 0.199583058171698 3930 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2111 5486399 200 µM -0.844772238108565 0.215026668037956 no 2667 0.199119008867384 3852 689674 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.845360908765857 0.214881871325908 no 2668 0.198954681664871 3900 688662 SGTC_2062 5245942 200 µM -0.845517009154115 0.214843484447503 no 2669 0.198911120011017 3953 1376160 SGTC_2816 7982706 58.44 µM -0.845843136477852 0.214763298849402 no 2670 0.198820128889002 3965 2981853 SGTC_2983 9022671 12.99 µM -0.847915696598064 0.214254120767908 no 2671 0.198242461103284 3935 6405161 SGTC_773 4358-1457 44.6 µM -0.848687561034879 0.214064671894199 no 2672 0.198027584791676 3869 1186886 SGTC_3176 9106582 49.47 µM -0.84950128298322 0.213865054986555 no 2673 0.19780120829873 3823 17018027 SGTC_2646 retinol 96.75 µM -0.851856089602633 0.213288000375024 no 2674 0.197146985360528 3896 445354 A vitamin A analog and teratogen. SGTC_2766 oltipraz 83.91 µM -0.852509261049023 0.213128099126483 no 2675 0.1969657505561 3850 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_925 2064-1272 59.6 µM -0.852583602730366 0.21310990416084 no 2676 0.196945129441344 3888 6815817 SGTC_2837 9008476 45.46 µM -0.853415221193455 0.212906429109702 no 2677 0.196714541752673 3899 2992805 SGTC_2077 5212015 200 µM -0.854105789173051 0.212737551580359 no 2678 0.196523188276338 3785 780900 SGTC_795 0685-0265 78 µM -0.854374739637497 0.212671801249535 no 2679 0.196448693763692 3941 302754 SGTC_2832 7992762 51.95 µM -0.855548765870988 0.21238492599719 no 2680 0.196123709748356 3873 2985177 SGTC_2067 5224629 34.075 µM -0.85573928198251 0.212338394403062 no 2681 0.196071003454077 3911 2835000 SGTC_2589 lobaric acid 100 µM -0.855947199761646 0.212287619430532 no 2682 0.196013492792532 3936 73157 A novel microtubule depolymerizer. SGTC_40 0327-0103 19.753 µM -0.856686362236557 0.212107168261817 no 2683 0.195809121173083 3799 409036 SGTC_1686 st019653 115.5 µM -0.860145632166586 0.21126385221955 no 2684 0.194854384882932 3860 97252 SGTC_80 0159-0065 512.242 µM -0.866862648955253 0.209631970198813 no 2685 0.193008635408998 3820 1548079 SGTC_671 0560-0003 407 µM -0.867314261954745 0.209522518594316 no 2686 0.192884922220914 3829 3238678 SGTC_1587 estradiol valerate 56.1 µM -0.869088148407476 0.209092930135467 no 2687 0.19239945929475 3974 13791 A steroid. SGTC_2233 sulbentine 40.3845 µM -0.869669162287933 0.208952336755052 no 2688 0.192240614675439 3901 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_745 0469-0705 296 µM -0.870071069021805 0.208855116201857 no 2689 0.19213078348963 4015 3486736 SGTC_1625 st003711 30.1 µM -0.871258412927882 0.208568055450389 no 2690 0.191806536030588 3989 24207034 YER133W GLC7 SGTC_723 4182-0001 115 µM -0.874111603534621 0.207879199511534 no 2691 0.191028739483529 3941 744821 YLR208W SEC13 SGTC_1555 citronellol 128 µM -0.874470779160166 0.207792577775691 no 2692 0.190930963361285 3844 8842 A terpine precursor. SGTC_1879 gemcitabine 100 µM -0.876290529376865 0.207354039639902 no 2693 0.190436056138297 3910 60750 A nucleoside analog which inhibits DNA replication. SGTC_1251 0490-5699 265 µM -0.876750683827161 0.207243234635713 no 2694 0.190311035419681 3981 3883818 SGTC_2829 7992743 58.44 µM -0.877531728990444 0.20705523945892 no 2695 0.19009894640044 3980 16462845 SGTC_2862 9027634 71.43 µM -0.877906139917015 0.206965155684126 no 2696 0.189997328456829 3870 5012562 SGTC_841 0251-0215 91.2 µM -0.882471967484995 0.205868478559681 no 2697 0.188760816263565 3970 3888614 SGTC_881 0833-0569 170 µM -0.884431259648315 0.20539893055848 no 2698 0.188231727294734 3954 5418700 SGTC_2175 5807670 165.306 µM -0.886459031257386 0.204913641735305 no 2699 0.187685110708965 3946 241186 SGTC_2764 methyldopa 94.69 µM -0.886760407829126 0.204841574153295 no 2700 0.187603953865593 3939 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_547 1120-0019 610 nM -0.891258635863766 0.203767714218913 no 2701 0.186395217033127 3890 3676939 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.89126204187717 0.203766902376482 no 2702 0.186394303621374 4019 165506 SGTC_3012 9080433 71.4286 µM -0.891628512237671 0.203679563372234 no 2703 0.186296041189978 3928 17688859 SGTC_807 1315-0151 48 µM -0.89220777934784 0.203541555142448 no 2704 0.186140786617008 3971 4011080 SGTC_3109 9122853 49.47 µM -0.895074897368648 0.202859296581175 no 2705 0.185373525941571 4016 1234709 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.898288065468232 0.202096317675131 no 2706 0.184515996751587 3990 2374 Ca(2+)-ATPase inhibitor. SGTC_2859 9028643 45.46 µM -0.898340269280505 0.202083935875692 no 2707 0.184502085015323 3860 17151580 SGTC_2999 9069765 71.4286 µM -0.899007487957081 0.201925723663857 no 2708 0.184324336105352 3976 2097066 SGTC_1132 3456-3614 2.5 µM -0.899032712236517 0.201919743887805 no 2709 0.184317618378059 4064 3125502 SGTC_341 1486-1430 230 µM -0.900553374316974 0.201559445066933 no 2710 0.183912917271422 3953 2054753 YPL210C SRP72 SGTC_1432 4049-0298 68.4 µM -0.903940108953083 0.200758392887971 no 2711 0.183013579854736 3994 741646 SGTC_997 3996-0078 137 µM -0.90473443443289 0.200570790945612 no 2712 0.182803046980524 4011 735687 SGTC_3159 9100096 49.47 µM -0.905241896808555 0.200450994789368 no 2713 0.182668625230377 3931 25236875 SGTC_237 nikkomycin 200 µM -0.905510221975814 0.200387668897913 no 2714 0.182597573506473 3986 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1681 tripelennamine 100 µM -0.9063641578335 0.200186216365496 no 2715 0.182371568658964 3949 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2744 captopril 92.04 µM -0.910819574151181 0.19913711204218 no 2716 0.181195223582131 3982 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3026 9090633 49.47 µM -0.913504009922074 0.198506617514739 no 2717 0.180488762798519 3982 25236842 SGTC_2085 5307070 144.047 µM -0.914608800473905 0.198247485084825 no 2718 0.180198518507088 3923 2840351 SGTC_1115 galangin 695.678 nM -0.916917050984103 0.197706736348827 no 2719 0.179593054132697 4028 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2944 9067346 25.62 µM -0.917334417234621 0.197609056126579 no 2720 0.179483713749895 3952 6473075 SGTC_1035 k081-0041 55.2 µM -0.918002310418593 0.197452803392566 no 2721 0.179308828139136 4000 731709 SGTC_2977 9011197 71.43 µM -0.91900791388283 0.197217684752802 no 2722 0.179045716416756 4097 2704722 SGTC_2711 st079103 59.1 µM -0.921437517177794 0.196650322250019 no 2723 0.178411024458594 3957 54693780 SGTC_3319 9138450 16.7555 µM -0.921789781219545 0.196568143474735 no 2724 0.178319119349688 3940 2029690 SGTC_2018 5133068 143 µM -0.921871122520657 0.19654917052848 no 2725 0.178297901778414 3982 785362 SGTC_2434 5670830 169.91 µM -0.923047318913931 0.196274945490743 no 2726 0.177991273232496 4038 1549830 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.923193715840301 0.196240829928072 no 2727 0.177953131564664 3787 4000243 SGTC_41 0478-0632 82.643 µM -0.923929250904019 0.196069479157706 no 2728 0.177761576220772 3898 3750424 SGTC_602 3130-1533 38.1 µM -0.924231947345559 0.195998989145712 no 2729 0.17768278280402 4033 720941 SGTC_2279 7948423 32.93 µM -0.926752314205545 0.195412659342211 no 2730 0.17702757441512 3923 1247112 SGTC_148 3253-0744 288.01 µM -0.927255900861236 0.195295634444561 no 2731 0.176896842475853 3915 6893655 SGTC_770 0389-1121 67.2 µM -0.928049693336916 0.195111257174377 no 2732 0.176690896543796 4126 6753108 SGTC_213 1246-0773 967 nM -0.928059226626619 0.195109043483217 no 2733 0.176688424095732 3981 6251622 SGTC_2139 5578692 56.4705 µM -0.929367660546536 0.194805361567623 no 2734 0.176349290761321 3957 650991 YMR113W FOL3 SGTC_1748 st037455 53.6035 µM -0.930353500085347 0.194576742451242 no 2735 0.176094042993046 4052 580690 SGTC_159 3970-0959 50 µM -0.930611132987709 0.194517023536906 no 2736 0.176027376764345 4087 6615653 SGTC_815 1582-0027 36.9 µM -0.93080915864305 0.194471129075019 no 2737 0.1759761456334 4072 3128206 SGTC_1378 2093-0007 380 nM -0.930956478314756 0.194436990517126 no 2738 0.175938038750516 4082 3618014 SGTC_1455 4262-0120 131 µM -0.934297790918304 0.193663684292494 no 2739 0.175075151767746 4101 1529587 SGTC_1715 st032160 10.2275 µM -0.936012289577397 0.193267613474934 no 2740 0.174633430102723 3965 5289825 SGTC_415 dibenzyl ketone 100 µM -0.936274128868535 0.193207168839924 no 2741 0.17456603244029 4016 7593 SGTC_2982 9019404 25.97 µM -0.938274212381961 0.19274583773729 no 2742 0.17405175431111 3965 22333232 SGTC_1116 jasmonic acid  1.58368 µM -0.938320894923682 0.192735078176783 no 2743 0.174039762421289 4081 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1866 st057638 64 µM -0.938449919665269 0.192705341998148 no 2744 0.174006621060877 3991 688802 SGTC_3209 9113616 49.47 µM -0.943263595232702 0.191597944127072 no 2745 0.172773045909451 4082 16649353 SGTC_2010 4012422 159 µM -0.945135268233535 0.19116841576084 no 2746 0.172294910904259 4016 952393 SGTC_2442 5158906 48.48 µM -0.947860603254428 0.19054403802823 no 2747 0.171600211731875 4057 1893835 SGTC_1996 st072960 66.8 µM -0.948169296706065 0.190473394987684 no 2748 0.171521637483866 4066 1719405 SGTC_908 3448-7491 47.7 µM -0.949562667823532 0.190154728746875 no 2749 0.171167257589068 4034 1203031 SGTC_3281 9140613 49.47 µM -0.950441547604388 0.189953896097146 no 2750 0.17094397066899 4044 16013766 SGTC_3199 9111318 49.47 µM -0.950794612041172 0.18987325413574 no 2751 0.170854324122229 3989 8548020 SGTC_2989 9073649 71.4286 µM -0.950865788307705 0.189856999614202 no 2752 0.170836255409579 3930 21367202 SGTC_1209 2323-2347 50.3 µM -0.95255342432501 0.189471844918138 no 2753 0.170408192619515 4045 5412760 SGTC_1784 st039334 36.3 µM -0.955316685441738 0.18884224858322 no 2754 0.169708786049105 4121 3496984 SGTC_1640 st009078 66.4 µM -0.955755608675944 0.188742360726518 no 2755 0.169597860268488 4014 690618 SGTC_2946 9065502 71.43 µM -0.955778392431913 0.188737176607581 no 2756 0.169592103570689 3844 16489101 SGTC_2842 9000675 19.48 µM -0.956627699873764 0.188543991420389 no 2757 0.169377601246311 4107 2989072 SGTC_1345 1488-0192 31.4 µM -0.961169419248634 0.187512993439929 no 2758 0.168233494920111 4092 658348 SGTC_725 1497-0963 19 µM -0.961389974743082 0.187463014861698 no 2759 0.168178061565718 4134 3549977 SGTC_924 2046-0044 21.3 µM -0.962471405890147 0.187218078286091 no 2760 0.167906429971353 4033 3623589 SGTC_2477 5967686 25.23 µM -0.962887971857388 0.187123781835061 no 2761 0.167801873198123 4036 776118 SGTC_752 1896-0090 130 µM -0.965712886969312 0.18648509189164 no 2762 0.167093934589714 4020 772567 SGTC_3128 9127691 49.47 µM -0.967770821857336 0.186020660957163 no 2763 0.166579419529635 4114 41316314 SGTC_1320 1313-0481 95.3 µM -0.968143914827106 0.185936538876412 no 2764 0.166486250220134 4048 6813365 YLR208W SEC13 SGTC_134 0269-0018 6.916 µM -0.971219059793425 0.185244078047838 no 2765 0.165719602291148 4025 4378915 SGTC_1749 st037932 54.2 µM -0.972565404350852 0.184941413029588 no 2766 0.16538467191733 4115 594497 SGTC_799 1310-0557 151 µM -0.976340064396248 0.184094490216799 no 2767 0.164447986048 4135 5354492 SGTC_473 2-arachidonoylglycerol 10 µM -0.977209393756436 0.183899780836103 no 2768 0.164232749188526 3906 5282280 An endocannabinoid. SGTC_219 mitoxanthrone 164.414 µM -0.977628883199243 0.183805870935016 no 2769 0.164128953364414 4019 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_827 3253-0474 693 µM -0.979084587031136 0.183480218431227 no 2770 0.163769093277536 4111 5402065 SGTC_581 0958-0271 211 µM -0.980922156809313 0.183069653362508 no 2771 0.16331556511791 4067 4591145 SGTC_495 decylubiquinone 155 µM -0.981325174021551 0.182979684611902 no 2772 0.163216206181429 4121 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_882 0843-0131 351 µM -0.982441734910261 0.182730569943474 no 2773 0.162941137034074 4056 5425421 SGTC_2965 9082772 38.63 µM -0.983800444545297 0.182427715483893 no 2774 0.162606820364514 4084 16459634 SGTC_34 0469-0683 81.75 µM -0.983870793792499 0.182412043278918 no 2775 0.162589522772761 4030 3690923 SGTC_1240 0356-0016 42.1 µM -0.984590995406044 0.182251647201594 no 2776 0.162412507249494 4054 4305613 SGTC_2691 st077356 60.2 µM -0.985660437204448 0.182013634527713 no 2777 0.162149884855941 4129 2839272 SGTC_173 1273-0061 2.693 µM -0.986066603261691 0.181923290027904 no 2778 0.162050215316283 4057 2847414 YPL266W DIM1 SGTC_1221 2958-7315 257 µM -0.987635845555425 0.181574503214321 no 2779 0.161665512180508 4101 4562705 SGTC_2059 5238311 157 µM -0.987985040111541 0.181496946631959 no 2780 0.16157998741702 4067 703021 SGTC_634 1611-4317 11.2 µM -0.988210567472273 0.181446867723098 no 2781 0.161524766913935 4079 2843522 SGTC_1228 0124-0032 52.5 µM -0.995665553375937 0.17979634089088 no 2782 0.159706336118074 4148 X1228 SGTC_1821 st053465 65.6 µM -0.998292101370588 0.179217079588853 no 2783 0.159068868304398 4089 675086 SGTC_1752 st044819 83.042 µM -0.998719919384676 0.179122839496881 no 2784 0.158965194212722 4091 441209 YML126C ERG13 SGTC_1344 1488-0097 29.1 µM -1.00075513020421 0.178674948653775 no 2785 0.158472603517301 4123 747966 SGTC_476 mead acid 10 µM -1.00091737211487 0.178639274290965 no 2786 0.158433378553997 4107 5312531 An omega 9 fatty acid. SGTC_697 0508-1955 564 µM -1.00184681925605 0.178434990407996 no 2787 0.158208790387561 4092 6243113 SGTC_1830 st055982 50.3 µM -1.00341995211205 0.178089565854789 no 2788 0.15782914069189 4028 455313 An antimicrobial agent. SGTC_1214 0358-0031 63.7 µM -1.00393149518181 0.177977333404372 no 2789 0.157705817217984 4225 4301366 SGTC_636 0kpi-0074 126 µM -1.00908614327789 0.176848894745804 no 2790 0.156466661431734 4101 616434 SGTC_1405 3909-7894 12 µM -1.01291079934083 0.176014542760762 no 2791 0.155551384799572 4101 7104060 SGTC_1204 4049-0315 18.3 µM -1.01308751911123 0.175976051527396 no 2792 0.155509179614674 4176 588402 SGTC_1642 st009582 77.7 µM -1.01311582954962 0.175969885742152 no 2793 0.155502419062629 4094 6739311 SGTC_1521 st012942 49.4 µM -1.01449506212644 0.175669665688539 no 2794 0.155173292209688 4097 24207259 SGTC_3117 9124945 49.47 µM -1.01676158889256 0.175177012025594 no 2795 0.154633429478622 4013 17592065 SGTC_1211 1056-0033 32.3 µM -1.01807661286147 0.174891579695599 no 2796 0.154320774328093 4170 6741922 SGTC_1855 st056195 39.6 µM -1.01887952443224 0.174717449048813 no 2797 0.154130082766124 4059 4028379 SGTC_618 k072-0232 33.2 µM -1.01900041460158 0.174691240650623 no 2798 0.154101384848083 4150 5872756 YGL099W LSG1 SGTC_1355 1499-0035 1.68 µM -1.0192024588554 0.174647444015354 no 2799 0.154053429786784 4103 1548538 SGTC_1966 st070145 16.1 µM -1.02143684156531 0.174163567325952 no 2800 0.153523758999492 4078 3748532 SGTC_3265 9137266 49.47 µM -1.0250461234747 0.173383744970402 no 2801 0.152670712515247 4026 17224265 SGTC_2742 clothiapine 36.27 µM -1.02993409409842 0.172331198228226 no 2802 0.151520472335611 4101 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1948 st076329 66.6 µM -1.03399566653298 0.171459710791808 no 2803 0.150569094553292 3983 24208413 SGTC_1813 st051246 8.6015 µM -1.03712787936913 0.170789562177869 no 2804 0.149838131866975 4052 5291959 SGTC_1102 cgs 12066b 26.1 µM -1.04032795246072 0.170106628189285 no 2805 0.14909378094833 4134 6438352 A 5-HT1B full agonist. SGTC_2746 daunorubicin 9.88 µM -1.04287340071086 0.169564650472853 no 2806 0.148503465207213 4078 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2700 st077718 96.8 µM -1.04444123979372 0.1692313775905 no 2807 0.14814064596867 4125 904970 SGTC_556 4058-0063 51.5 µM -1.04662653436676 0.168767555323818 no 2808 0.147635929488964 4162 6615692 SGTC_1196 1588-0294 184 µM -1.05260251817557 0.167503346429096 no 2809 0.146261601289262 4159 6144269 SGTC_394 menadione 8.33 µM -1.05263523506935 0.167496442062543 no 2810 0.146254100938475 4130 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1919 st067113 52.3 µM -1.05363443468139 0.167285665601673 no 2811 0.146025158742662 4173 1268243 SGTC_1343 1487-0095 224 µM -1.05730899033963 0.166512006435166 no 2812 0.145185295763906 4165 4560101 YGL055W OLE1 SGTC_546 peri-Naphthalide 147 µM -1.05793495055329 0.16638044427693 no 2813 0.145042549858398 4079 223824 A penicillin ester. SGTC_1793 st048256 72.231 µM -1.05943517158311 0.166065406277782 no 2814 0.144700819439187 4043 672022 SGTC_1798 st045719 60.953 µM -1.05948073447194 0.166055844361122 no 2815 0.144690449310485 4057 3980186 SGTC_2572 astragaloside iv 100 µM -1.06013009267671 0.165919607446596 no 2816 0.144542709570893 4202 45006101 An anti-inflammatory agent. SGTC_1999 st074831 12.5 µM -1.06137199647088 0.165659254293579 no 2817 0.144260439055764 4115 17112523 SGTC_2878 9043973 25.97 µM -1.06242196902458 0.165439343875644 no 2818 0.144022082383419 4208 6465167 SGTC_474 dl-dihydrosphingosine 5 µM -1.06272537849249 0.165375831780432 no 2819 0.143953254197945 4181 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3162 9099653 49.47 µM -1.06526826763899 0.164844154158896 no 2820 0.1433772741302 4138 25237511 SGTC_1836 st055642 81 µM -1.06543777162683 0.164808752976726 no 2821 0.143338935830359 4167 8571 SGTC_2771 fluoxetine 41.05 µM -1.06838414647542 0.164194184668857 no 2822 0.142673632649171 4174 3386 A selective serotonin reuptake inhibitor. SGTC_605 1315-0399 119 µM -1.06842654524714 0.164185351801046 no 2823 0.142664074100831 4234 24020461 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.0700751800814 0.163842133331912 no 2824 0.142292735012228 4171 77254 SGTC_2033 5192550 145 µM -1.07375035585543 0.163078699841827 no 2825 0.141467292765165 4181 182073 SGTC_1258 0671-0043 57.1 µM -1.074281316678 0.162968596362735 no 2826 0.141348308090754 4185 4298767 SGTC_748 act1.228 77.9 µM -1.07772001435546 0.162256696033725 no 2827 0.140579361953101 4112 4421505 YNR035C ARC35 SGTC_2129 girgensonine 121.053 µM -1.07791973643452 0.16221541064487 no 2828 0.1405347884126 4182 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.07971596412493 0.16184441228403 no 2829 0.14013434137022 4227 5393153 SGTC_3170 9103054 49.47 µM -1.08427596236405 0.160905061600547 no 2830 0.139121229939597 4153 16432970 SGTC_1239 0337-0584 35.4 µM -1.08524738485593 0.160705411240137 no 2831 0.138906051203551 4252 914301 YML130C ERO1 SGTC_335 4077-0256 27.6 µM -1.0868656217053 0.160373184554873 no 2832 0.138548100744901 4136 3121989 SGTC_1077 5-fluorocytosine 377 nM -1.08707466423287 0.160330300536775 no 2833 0.138501906873588 4237 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_732 3970-1727 52.7 µM -1.08731635741469 0.16028072774412 no 2834 0.138448510998048 4250 1275699 SGTC_2368 9071271 200 µM -1.089932285108 0.159744825567022 no 2835 0.13787148683932 4177 27209959 SGTC_2783 7738165 71.43 µM -1.09109612664895 0.159506776802564 no 2836 0.137615293511394 4183 17201110 SGTC_736 0958-0254 92.6 µM -1.09131928062179 0.159461160081165 no 2837 0.137566208371689 4271 6812352 SGTC_2080 5212524 12.4 µM -1.09139630807885 0.159445416254127 no 2838 0.137549268120918 4087 260183 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.09464327615704 0.158782686233444 no 2839 0.13683647419105 4031 88881 An O-methylated flavonoid and antioxidant. SGTC_246 cycloheximide 667 µM -1.0949459653515 0.158720997290122 no 2840 0.136770154930902 4068 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2667 digitoxin 100 µM -1.09525939279271 0.158657136421502 no 2841 0.136701506078561 4117 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2443 5493264 126.67 µM -1.09680697446546 0.158342063512327 no 2842 0.136362890357757 4231 5340055 SGTC_1241 0364-0022 50.8 µM -1.09735613671308 0.158230358049618 no 2843 0.136242869993514 4203 4563895 SGTC_2457 5731572 11.68 µM -1.09747671487892 0.15820583808925 no 2844 0.136216527106844 4232 2865357 SGTC_1051 3253-3903 78 µM -1.0999279194684 0.157707918321174 no 2845 0.135681764469646 4172 5509239 SGTC_2089 5281248 129.67 µM -1.10056133728841 0.1575794180184 no 2846 0.135543810149521 4173 2737878 SGTC_1392 3455-1037 33.9 µM -1.1008145272752 0.157528073084513 no 2847 0.135488693896376 4195 981132 SGTC_2616 abietic acid 100 µM -1.10173041014082 0.157342431080852 no 2848 0.13528944606581 4236 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3352 9151559 45.5865 µM -1.1029499584724 0.157095461891308 no 2849 0.135024448566781 4195 17159339 SGTC_155 k072-0202 43.6 µM -1.10531051147525 0.15661815400971 no 2850 0.134512532375064 4174 5857737 SGTC_466 geldanamycin 89.2 µM -1.10734313518847 0.15620791974433 no 2851 0.134072800708386 4139 5288382 HSP90 inhibitor. SGTC_2166 5933061 31.504 µM -1.10741853109655 0.156192716594752 no 2852 0.134056508804081 4343 2877375 SGTC_3179 9107801 49.47 µM -1.10792544957998 0.15609052472142 no 2853 0.133947006777287 4195 4818259 SGTC_1769 st044406 64.4 µM -1.11061910397535 0.155548238625526 no 2854 0.133366168069803 4177 670903 SGTC_1628 st004252 77.7 µM -1.11137064538764 0.155397160436698 no 2855 0.133204421135422 4230 692968 SGTC_3069 9117009 49.47 µM -1.11180953652127 0.15530897739254 no 2856 0.133110025333721 4191 41904981 SGTC_2196 6573537 42.6665 µM -1.11228865050037 0.155212750391334 no 2857 0.13300703105944 4215 2903087 SGTC_2954 9074818 52.69 µM -1.1157463969437 0.154519451114003 no 2858 0.132265352156467 4239 16648742 SGTC_3027 9089541 49.47 µM -1.11697309769495 0.154273982795419 no 2859 0.132002913997873 4211 9943819 SGTC_374 0880-0231 82.3 µM -1.11760965045558 0.154146707417383 no 2860 0.131866872663324 4102 6833587 SGTC_2504 purpurogallin 52.29 µM -1.11913360518413 0.153842282943095 no 2861 0.131541572618188 4102 5281571 An antioxidant. SGTC_126 0417-1624 672.48 µM -1.12088278235666 0.153493358938773 no 2862 0.131168880338623 4262 41912 YDL195W SEC31 SGTC_114 0364-0001 490.298 µM -1.12252086951386 0.153167070680712 no 2863 0.130820519625457 4255 4003655 SGTC_2290 7904846 200 µM -1.12464413993943 0.152744823999749 no 2864 0.130369930665831 4267 2962154 SGTC_3327 9140648 26.9345 µM -1.12490971683402 0.152692064112965 no 2865 0.130313647002641 4240 8029710 SGTC_1992 st073643 23.3 µM -1.12541480675519 0.152591755586412 no 2866 0.130206649778974 4190 3161292 SGTC_2318 6029776 164 µM -1.12556470546042 0.152561994810258 no 2867 0.130174907242088 4278 818325 SGTC_985 1493-0307 8.71 µM -1.13247067807145 0.151195063938961 no 2868 0.128718302553773 4238 3278274 SGTC_223 busulfan 5 mM -1.13251258072897 0.151186794899633 no 2869 0.12870949911802 4224 2478 A DNA alkylator. SGTC_3080 9117754 49.47 µM -1.13298728234854 0.151093138644839 no 2870 0.128609797021697 4232 9550191 SGTC_2456 5770359 74.46 µM -1.14338770882034 0.149050874946245 no 2871 0.126438826694212 4251 3118787 SGTC_2064 5220758 200 µM -1.14879487111124 0.147996424959672 no 2872 0.125320287379102 4301 788518 SGTC_1071 trifluoperazine 6.31 µM -1.15011121655115 0.147740482180216 no 2873 0.125049033580241 4313 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_49 0717-0965 32.132 µM -1.15189819586336 0.147393506587759 no 2874 0.124681454848616 4321 5889349 YGL099W LSG1 SGTC_1862 st057513 3.81 µM -1.15200030265153 0.147373697143026 no 2875 0.124660474480706 4223 5393163 SGTC_89 0302-0250 142.109 µM -1.15235337288921 0.147305212751519 no 2876 0.124587946476915 4342 4203518 YLR208W SEC13 SGTC_1704 st028805 70.8 µM -1.15313368166127 0.147153933350142 no 2877 0.124427759400747 4285 2876101 SGTC_344 k064-0035 6.43 µM -1.15377909870709 0.147028884301008 no 2878 0.12429537268013 4186 5088750 SGTC_1520 flindersine 88 µM -1.15419942017898 0.146947485668453 no 2879 0.124209210124699 4312 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2128 5255449 168.493 µM -1.15485758125534 0.146820088209791 no 2880 0.124074376293322 4198 736008 SGTC_1739 st037196 92.5 µM -1.15518750984809 0.146756253214687 no 2881 0.124006824191879 4297 612214 SGTC_357 1325-0123 420 µM -1.1580799461382 0.146197418301052 no 2882 0.123415706447211 4259 1098503 SGTC_2664 lyso-paf C-16 73.48 µM -1.16277384316726 0.145293576365137 no 2883 0.12246063616137 4216 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2870 9038528 12.99 µM -1.16573968103492 0.144724426196855 no 2884 0.121859855716996 4298 6463316 SGTC_33 0986-0033 35.816 µM -1.1661524765647 0.144645329120722 no 2885 0.12177640145468 4215 2848082 SGTC_644 1498-1197 63.3 µM -1.16701269720048 0.144480593068216 no 2886 0.12160262096982 4274 6741615 SGTC_65 0798-0905 34.986 µM -1.16786573873425 0.144317356733685 no 2887 0.121430462988432 4331 3602145 SGTC_3100 9120536 49.47 µM -1.16902908210107 0.144094942088524 no 2888 0.12119595722545 4114 16421196 SGTC_861 0443-0273 110 µM -1.16971874893517 0.143963196819946 no 2889 0.121057085255556 4253 6149169 SGTC_2803 7707263 71.43 µM -1.17098533766468 0.143721455327527 no 2890 0.120802335410291 4240 2199229 SGTC_1756 st041558 35.5 µM -1.17210034332207 0.143508871853683 no 2891 0.120578386055791 4348 3955792 SGTC_548 1436-0017 110 µM -1.17446275594493 0.143059163297494 no 2892 0.120104860714322 4321 9677137 SGTC_738 1315-0003 72.4 µM -1.17721514789388 0.142536420383406 no 2893 0.11955482204734 4299 6251474 SGTC_2208 7283366 200 µM -1.17769582629071 0.142445261102124 no 2894 0.119458945711637 4251 898663 SGTC_211 3455-0679 143.504 µM -1.17836550753918 0.142318323727206 no 2895 0.119325461234016 4293 748649 SGTC_1061 3448-9325 110 µM -1.17838945860377 0.142313785246125 no 2896 0.11932068912908 4222 723482 SGTC_597 k018-0003 82.8 µM -1.18015690268257 0.141979142936569 no 2897 0.118968908186719 4330 6786234 SGTC_566 0958-0068 16.5 µM -1.18102665116437 0.141814663224171 no 2898 0.11879606805454 4180 6815365 SGTC_1570 verbenone 133 µM -1.18235106126792 0.141564449571079 no 2899 0.118533216444194 4287 29025 A natural terpanoid with antifungal properties. SGTC_1799 st045822 46.1415 µM -1.18282283497587 0.141475392204228 no 2900 0.118439684318846 4251 3674992 SGTC_2395 5646831 180.19 µM -1.1830563663989 0.141431322209582 no 2901 0.118393404542934 4283 6808628 SGTC_2515 chrysin 20.77 µM -1.18500389565692 0.141064163944702 no 2902 0.118007953319967 4286 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1150 3909-7983 10.9 µM -1.18504723682094 0.141056000404162 no 2903 0.117999385429714 4257 23965914 SGTC_3158 9100007 49.47 µM -1.18590832188936 0.14089387683101 no 2904 0.117829253192935 4291 19297233 SGTC_2350 9023895 38.85 µM -1.18637556083844 0.140805958833666 no 2905 0.117737009315355 4282 2997209 SGTC_1255 0566-0045 221 µM -1.18736856553385 0.140619233785497 no 2906 0.11754113675824 4286 2788469 SGTC_893 0958-0369 48.9 µM -1.18737087393077 0.140618799909398 no 2907 0.117540681690343 4185 6819948 SGTC_2879 9041815 71.43 µM -1.18878651334258 0.140352893701137 no 2908 0.117261843235517 4292 4942971 SGTC_690 glyoxal 20.3 µM -1.19119835677818 0.139900652669971 no 2909 0.1167878622457 4077 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1562 morin hydrate 59.1 µM -1.19266250065002 0.139626596937802 no 2910 0.116500788713204 4311 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2391 6285546 200 µM -1.1949292917624 0.13920302371179 no 2911 0.116057328653601 4286 846083 SGTC_589 1227-0070 34.1 µM -1.19538741120828 0.139117525716673 no 2912 0.115967850931703 4338 2841384 SGTC_1259 0671-0132 43 µM -1.19916242296637 0.138414362960062 no 2913 0.115232397746996 4205 X1259 SGTC_1928 4'-methoxychalcone 40.3 µM -1.20054611729927 0.138157233085075 no 2914 0.114963656604392 4306 641818 SGTC_988 1497-1057 103 µM -1.20461536018312 0.13740293990469 no 2915 0.114175912106866 4267 3533044 SGTC_541 4513-1321 94 µM -1.20891502265808 0.136608995690327 no 2916 0.113347747024741 4259 747515 SGTC_2557 derrustone 83.84 µM -1.20940895071225 0.13651799184444 no 2917 0.113252885804522 4261 629853 An antioxidant. SGTC_1327 1436-0082 2.18 µM -1.21627072483934 0.135258031787876 no 2918 0.111940904839384 4299 15992205 SGTC_1298 1079-1278 263 µM -1.21686149551206 0.135149928309622 no 2919 0.111828458870124 4270 2840950 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.21695355172777 0.135133088535792 no 2920 0.111810944373138 4284 688669 SGTC_2928 9011484 9.79 µM -1.21850297792519 0.134849869068541 no 2921 0.111516446907391 4311 2994751 SGTC_1729 st035615 45.989 µM -1.21972300783444 0.134627146684465 no 2922 0.111284948288997 4322 17385451 SGTC_958 1222-0007 33 µM -1.22168544159304 0.134269424789917 no 2923 0.11091330189857 4368 7312461 SGTC_2886 9058944 51.95 µM -1.22220482953016 0.134174857601255 no 2924 0.110815088996783 4189 4949929 SGTC_1871 st057448 67.3 µM -1.22251554113847 0.134118306882999 no 2925 0.110756365235609 4338 691747 SGTC_2379 9035213 200 µM -1.22328787748471 0.133977809613516 no 2926 0.110610492098423 4296 646551 SGTC_872 0588-0139 234 µM -1.22380659628204 0.133883505218163 no 2927 0.11051259768616 4258 2047100 SGTC_999 SEC7.066 22.7 µM -1.22977354982562 0.132801978360218 no 2928 0.109390957823817 4269 740511 YDR170C SEC7 SGTC_2199 6590217 200 µM -1.22992716914943 0.132774214102204 no 2929 0.109362189551253 4208 703109 SGTC_1730 st033808 45.1 µM -1.23189308896815 0.132419258154877 no 2930 0.108994511684494 4250 1045166 SGTC_701 4424-0219 185 µM -1.23281942897416 0.132252230035557 no 2931 0.108821570449409 4343 2911779 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.23317616577595 0.132187945668722 no 2932 0.108755022818511 4332 6708760 SGTC_2181 6316240 54.2555 µM -1.23729495187391 0.13144729593051 no 2933 0.107988800655232 4316 12779990 SGTC_559 1550-0661 158 µM -1.23739111327643 0.131430038255202 no 2934 0.107970958201963 4374 5830875 SGTC_763 3453-1109 128 µM -1.23972882353672 0.131010980591651 no 2935 0.107537856144495 4346 1560353 SGTC_1347 1493-0251 600 nM -1.23982813824035 0.130993197915627 no 2936 0.107519484107886 4359 3986378 SGTC_2074 5212007 75.395 µM -1.23985716572654 0.130988000748615 no 2937 0.107514114796072 4213 758611 SGTC_2702 st077768 96.8 µM -1.2421995370068 0.130569085212338 no 2938 0.107081475230747 4294 6484119 SGTC_228 caffeine 993.056 µM -1.24352493238048 0.130332459020029 no 2939 0.106837229618007 4320 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2118 5526350 200 µM -1.243793984715 0.130284460670587 no 2940 0.10678769741832 4359 743594 SGTC_2159 5658611 73.75 µM -1.24439217837903 0.130177788051311 no 2941 0.106677630092486 4305 793844 SGTC_2640 pentamidine 10.38 µM -1.24732295962433 0.129656031286145 no 2942 0.106139551072657 4298 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3043 9092303 49.47 µM -1.25271902625459 0.128699180860191 no 2943 0.105153989628121 4345 25236084 SGTC_1971 st069429 63.5 µM -1.25319577457453 0.128614878269326 no 2944 0.105067233672509 4328 1246522 YGL099W LSG1 SGTC_2221 6807166 181.081 µM -1.25350837238743 0.128559622937342 no 2945 0.105010377022924 4289 674925 SGTC_137 0438-0332 85.389 µM -1.25415765506053 0.128444907258805 no 2946 0.104892353843929 4286 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2789 5281112 71.43 µM -1.25790527779245 0.127784163650102 no 2947 0.104213007374092 4340 765948 SGTC_2156 5649887 115 µM -1.25822356480659 0.127728155479258 no 2948 0.104155457499212 4359 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.25823909620267 0.127725422894976 no 2949 0.104152649837641 4312 2724 A muscle relaxant with antifungal properties. SGTC_472 calcifediol 10 µM -1.26005633814404 0.127405978949504 no 2950 0.103824519705394 4383 5283731 A vitamin D metabolite. SGTC_810 3825-7150 143 µM -1.26150842063928 0.127151124270493 no 2951 0.103562864030052 4386 22330411 YGL099W LSG1 SGTC_2959 9079155 11 µM -1.26158209563501 0.127138203050217 no 2952 0.103549601049749 4352 16189457 SGTC_1085 doxorubicin 7.67 µM -1.26365645586404 0.126774773913312 no 2953 0.103176680304683 4352 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2424 5537928 59.2 µM -1.26473548223397 0.12658601412046 no 2954 0.102983083014855 4342 5382802 SGTC_181 1447-1644 8.07 µM -1.2655747265374 0.126439336075831 no 2955 0.102832689601934 4313 534600 SGTC_2031 5180455 200 µM -1.2665851456969 0.12626289827942 no 2956 0.10265183329651 4321 29949 SGTC_551 k048-0028 34.9 µM -1.26669679872491 0.126243412137346 no 2957 0.102631862562762 4305 6836383 SGTC_161 4065-0411 162.148 µM -1.26831419176454 0.125961373175394 no 2958 0.102342885493486 4327 1906281 YLR208W SEC13 SGTC_2671 danthron 100 µM -1.27300408490675 0.125146040760375 no 2959 0.10150829616298 4339 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2426 5582046 32.21 µM -1.27336506287108 0.125083438269282 no 2960 0.101444264422437 4350 2251934 SGTC_2898 9056270 58.44 µM -1.28473977350442 0.123121977594523 no 2961 0.0994416172797684 4355 19154699 SGTC_1891 st059073 26.2 µM -1.28480476862297 0.123110832099653 no 2962 0.0994302577872394 4428 688754 SGTC_490 phenamil 164 µM -1.28510059573358 0.123060112000708 no 2963 0.0993785667208555 4341 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3023 9089636 49.47 µM -1.28819043047653 0.12253122955815 no 2964 0.0988398411606242 4416 17249241 SGTC_435 c-PAF 6.7 µM -1.2989437481493 0.120703041456218 no 2965 0.0969816172751141 4320 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2295 7971645 200 µM -1.29982294030327 0.120554422320428 no 2966 0.0968308305487347 4414 2978226 YKL099C UTP11 SGTC_947 3447-0010 211 µM -1.29992839026381 0.120536605657704 no 2967 0.0968127568164867 4327 748350 SGTC_1021 4476-0760 85.3 µM -1.30375128741572 0.119891946551397 no 2968 0.096159198191838 4384 746768 SGTC_1389 3405-0187 19 µM -1.30375989207268 0.119890498286102 no 2969 0.0961577308159251 4344 799890 SGTC_912 3474-0017 2.18 µM -1.30433738327636 0.119793327891936 no 2970 0.0960592872683939 4387 3360550 SGTC_1409 3909-8004 61.9 µM -1.30442968937915 0.119777801340406 no 2971 0.0960435589387774 4418 2119279 SGTC_812 4251-0442 148 µM -1.30897251321298 0.119015418403384 no 2972 0.0952718308444366 4385 5723007 SGTC_1210 3013-0140 750 nM -1.31831259244724 0.11745873300211 no 2973 0.0936995136336608 4399 905973 SGTC_1365 1672-3266 55.4 µM -1.31881899649626 0.11737474598419 no 2974 0.0936148159321882 4402 6415873 SGTC_1237 0330-0133 46.1 µM -1.32152774164004 0.116926223239797 no 2975 0.0931627294057157 4312 X1237 YHR072W ERG7 SGTC_2481 5478948 45.16 µM -1.32267068150241 0.116737336447425 no 2976 0.0929724587821232 4388 77792 SGTC_1183 1254-0324 198 µM -1.32682916021371 0.116051915476932 no 2977 0.092282601025622 4452 5799357 SGTC_2740 felodipine 17.08 µM -1.32888244253833 0.115714538877255 no 2978 0.0919433786010596 4433 3333 L-type calcium channel blocker SGTC_1653 st012112 65 µM -1.3308132255994 0.115397926310571 no 2979 0.0916252375357517 4379 720429 SGTC_2223 6903751 107.57 µM -1.33307992042192 0.115027016687613 no 2980 0.0912527890183497 4350 5598863 SGTC_21 0849-0113 22.993 µM -1.33594537576408 0.114559343510902 no 2981 0.0907835640738721 4355 1560156 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.33633696026983 0.114495537959965 no 2982 0.0907195805119922 4384 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_268 camptothecin 39.6153 µM -1.33737126328499 0.114327128248462 no 2983 0.0905507399064587 4365 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1644 st010134 20.9 µM -1.33813958535004 0.114202140936547 no 2984 0.0904254693688621 4372 3818134 SGTC_2681 menadione 3.18 µM -1.3394999358257 0.113981083744801 no 2985 0.0902039876615778 4425 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.34046880392608 0.113823828503839 no 2986 0.0900464899504778 4289 4330530 SGTC_2311 7694451 200 µM -1.34297953699175 0.113417035604227 no 2987 0.0896392999737991 4388 2163142 SGTC_1810 st050138 53 µM -1.34402817002145 0.113247441761396 no 2988 0.0894696388734477 4400 3444541 SGTC_2506 ethyl hematommate 54.16 µM -1.34406455893758 0.113241559886371 no 2989 0.0894637557055313 4432 3940691 An allergen. SGTC_2721 ifenprodil 61.44 µM -1.34498551332591 0.113092770113301 no 2990 0.0893149564350205 4399 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1393 3470-5649 58.2 µM -1.35113721720013 0.112102475787372 no 2991 0.0883257407336082 4392 4108395 SGTC_959 1222-0044 107 µM -1.35460814288231 0.111546473196179 no 2992 0.0877712188652842 4388 6083612 SGTC_2919 7978188 46.38 µM -1.35640714923204 0.111259070620803 no 2993 0.0874848299146971 4420 2980291 SGTC_1039 k821-0043 94 µM -1.358837260997 0.110871687266554 no 2994 0.0870990815787445 4381 15992768 SGTC_299 1273-0059 1.44 µM -1.36011355620161 0.110668620897491 no 2995 0.0868969959282684 4200 2848077 SGTC_2861 9024595 19.48 µM -1.36133978298063 0.110473771919099 no 2996 0.0867031681430802 4331 16482810 SGTC_2374 9071832 200 µM -1.36511509786619 0.10987541422278 no 2997 0.0861084387378325 4343 17381698 SGTC_523 1934-0222 13.7 µM -1.36683988694757 0.109602824130412 no 2998 0.0858377487067305 4359 1361595 SGTC_753 1322-0200 289 µM -1.37096123896041 0.108953442262791 no 2999 0.0851935197043767 4465 5403907 SGTC_2022 5136654 200 µM -1.37115285307419 0.108923317963383 no 3000 0.085163655927151 4424 1713771 SGTC_1422 4031-0024 15.5 µM -1.3727555226662 0.108671591341128 no 3001 0.0849141809976312 4362 782427 SGTC_2651 TUB2.036 5 µM -1.37836625737815 0.107793626540933 no 3002 0.0840451179186949 4343 15992207 YFL037W TUB2 SGTC_2238 6671620 73.2395 µM -1.37878191046303 0.107728789227271 no 3003 0.0839810028637668 4334 729941 SGTC_106 0092-0003 11.579 µM -1.37891018186745 0.107708785971793 no 3004 0.0839612242424259 4323 1072148 SGTC_2312 7706453 155.7 µM -1.38076735371648 0.107419469506579 no 3005 0.0836752521627816 4418 976098 SGTC_1508 1080-0625 72.9 µM -1.38307737185882 0.107060389347159 no 3006 0.0833205715798725 4340 767111 SGTC_1453 4237-0541 195 µM -1.38436346887162 0.106860847905314 no 3007 0.0831235944227042 4416 739892 SGTC_2421 5690543 90.72 µM -1.38535504104688 0.106707186086805 no 3008 0.0829719655867825 4429 3397993 SGTC_798 1287-0182 476 µM -1.38577815185734 0.106641666072745 no 3009 0.0829073278639542 4456 1649755 SGTC_3013 9080133 71.4286 µM -1.38651111801874 0.106528232732033 no 3010 0.0827954438719042 4485 17050193 SGTC_1123 mangostin 811.285 nM -1.38857967643447 0.106208573905995 no 3011 0.0824803004813983 4432 5281650 An antioxidant. SGTC_3329 9141233 27.5565 µM -1.38949641052481 0.106067130780371 no 3012 0.0823409258345191 4386 4909101 YNL103W MET4 SGTC_3326 9140064 16.379 µM -1.39021203542686 0.105956811464494 no 3013 0.0822322499130479 4373 1868434 SGTC_1295 1013-0063 9.78 µM -1.39028699180256 0.105945261137388 no 3014 0.0822208731732904 4447 6826038 SGTC_37 0566-0070 1.56 µM -1.39183051045505 0.105707616442306 no 3015 0.0819868642464591 4346 1626686 SGTC_656 4090-1979 187 µM -1.39357832976059 0.105438982563983 no 3016 0.081722488079384 4451 22330961 SGTC_2204 7233102 200 µM -1.39455563798845 0.105288989033112 no 3017 0.0815749402761701 4382 2172480 SGTC_1411 3909-8223 150 µM -1.39683750086429 0.104939378591575 no 3018 0.0812312212103277 4444 X1411 SGTC_2857 9024691 58.44 µM -1.40427180757263 0.103806178933807 no 3019 0.0801189630361233 4468 16478292 SGTC_2689 tacrolimus 100 µM -1.40554102180617 0.103613605044418 no 3020 0.0799302299471325 4439 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2298 7976326 193.81 µM -1.41094208735421 0.102797016970337 no 3021 0.0791308454439265 4383 2235818 SGTC_1509 1326-1131 80 µM -1.4145045015681 0.102260980599592 no 3022 0.0786069132977164 4428 768313 SGTC_1175 0741-0056 27.6 µM -1.41783610789881 0.101761516317166 no 3023 0.0781193097789444 4515 765927 SGTC_2479 5617353 43.85 µM -1.42184176308033 0.101163354816262 no 3024 0.077536096306309 4460 2731746 SGTC_2827 7993847 71.43 µM -1.42599308942764 0.10054614839739 no 3025 0.0769351684125908 4494 2985692 SGTC_1766 st045414 44.774 µM -1.43088617356747 0.0998221925034536 no 3026 0.0762314201565095 4460 253960 SGTC_2309 7664088 163.95 µM -1.43176800375393 0.0996921273439318 no 3027 0.0761051135433739 4436 704922 SGTC_1886 st057356 49.9 µM -1.43473892593538 0.0992548438049381 no 3028 0.0756807536969617 4443 24207747 SGTC_2360 9040895 200 µM -1.43754972655733 0.0988424208894514 no 3029 0.075280927000552 4476 4914414 SGTC_2544 sphondin 68.51 µM -1.43961712684243 0.0985398768660595 no 3030 0.0749878756898552 4422 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2009 4012297 12.05 µM -1.44045196222493 0.0984178991377913 no 3031 0.0748697857764923 4433 45595307 SGTC_87 0100-0052 35.5 µM -1.44201961575883 0.0981891482171939 no 3032 0.0746484199861157 4477 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2259 7964009 200 µM -1.44745760951678 0.0973986589774651 no 3033 0.0738844003776327 4476 313134 SGTC_2102 5377816 72.7585 µM -1.44820401465236 0.097290523838727 no 3034 0.073780001075381 4501 1379702 SGTC_1113 artemisinin 1.17947 µM -1.44916355714395 0.097151639951524 no 3035 0.0736459560501383 4497 2240 An anti-malaria and mitochondrial poison. SGTC_1054 3429-0080 167 µM -1.45266494362423 0.0966460844833556 no 3036 0.073158402438685 4482 1162877 SGTC_1988 st071872 53.4 µM -1.46092135548592 0.0954616199366509 no 3037 0.0720185126195029 4494 16414116 SGTC_2536 dehydroabietamide 32.04 µM -1.46258540459758 0.0952241947655263 no 3038 0.0717904296963033 4518 3983547 SGTC_2306 7482397 179.52 µM -1.46709543035041 0.094582894679154 no 3039 0.0711750485314013 4472 891448 SGTC_3175 9106517 49.47 µM -1.47246170945976 0.0938239948809868 no 3040 0.0704481198442906 4490 41468073 SGTC_3177 9107506 49.47 µM -1.4749040896939 0.0934800853856128 no 3041 0.0701191653380282 4443 8897194 SGTC_1892 st058411 7.36 µM -1.47728057180183 0.0931463495316304 no 3042 0.0698002218201923 4481 3934738 SGTC_540 1187-0821 17.3 µM -1.4793241464182 0.0928600696195798 no 3043 0.0695268511728542 4407 847520 SGTC_1118 chelidonine 707.474 nM -1.47963831612966 0.0928161160267272 no 3044 0.0694848976487299 4472 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_593 1203-0218 61.7 µM -1.48166636173265 0.092532754498042 no 3045 0.0692145459098204 4522 3666956 SGTC_2271 7849410 118.62 µM -1.48345529197323 0.0922833342201348 no 3046 0.0689767431920252 4406 972430 SGTC_3252 9135871 49.47 µM -1.48887147336284 0.0915312213142777 no 3047 0.0682606083689424 4504 17682838 SGTC_919 tnp00227 403.569 nM -1.48903201370375 0.0915089975587703 no 3048 0.0682394694027349 4451 1269246 A methoxyflavone. YNL221C POP1 SGTC_1097 itavastatin 7.23 µM -1.49945053156879 0.0900752890799364 no 3049 0.0668783964309715 4512 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_32 0928-0142 34.1 µM -1.50373517925253 0.089490539648813 no 3050 0.0663247836551672 4504 2244242 SGTC_2289 7946404 165.07 µM -1.50715502758979 0.0890258438185211 no 3051 0.0658854623325839 4470 1246120 YPR165W RHO1 SGTC_432 NS 1619 61.3 µM -1.50717357115689 0.0890233289867742 no 3052 0.0658830863470908 4469 4552 A K+/calcium channel activator. SGTC_2277 7947813 106.88 µM -1.50792645510062 0.0889212694177918 no 3053 0.0657866754662982 4515 1246798 SGTC_600 1495-0418 41.6 µM -1.51294285026586 0.0882434788101086 no 3054 0.0651470880857686 4478 5377768 SGTC_17 0960-0276 49.807 µM -1.51566696168728 0.0878770273974237 no 3055 0.0648017928653305 4507 6821114 SGTC_365 0121-0052 13.6 µM -1.51745159547322 0.08763757195742 no 3056 0.0645763528473726 4487 3101739 SGTC_1561 5-methoxyflavone 52.9 µM -1.51745529910966 0.0876370755241566 no 3057 0.0645758856277547 4466 94525 SGTC_2532 xanthone 78.9 µM -1.52351610651923 0.0868274966436148 no 3058 0.0638148171067488 4528 7020 An insecticide. SGTC_1908 st060353 56.5 µM -1.52968676594211 0.0860089983302547 no 3059 0.0630471404750445 4519 4227716 SGTC_565 1418-0001 44.5 µM -1.53119244235148 0.0858101590667596 no 3060 0.0628609190504918 4546 2862145 SGTC_1939 st074455 53.6 µM -1.53690198247886 0.0850592841942835 no 3061 0.0621586569890269 4464 1644229 SGTC_321 4534-3890 65.3 µM -1.53728908671746 0.0850085540360149 no 3062 0.0621112663774437 4517 699746 SGTC_2847 9005661 71.43 µM -1.53847623826023 0.0848531187913027 no 3063 0.0619661070338563 4548 2991449 SGTC_1494 4358-1428 177 µM -1.53876354440443 0.0848155334810772 no 3064 0.0619310164005225 4526 1564571 SGTC_2276 7947513 42.08 µM -1.54207844077189 0.084382782139099 no 3065 0.0615272666249774 4444 2105100 SGTC_271 rotenone 740 µM -1.5482313948192 0.0835839245941076 no 3066 0.0607832976200748 4548 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2913 7966556 36.57 µM -1.55363546758581 0.0828869957397508 no 3067 0.060135697059627 4422 2976516 SGTC_2724 maprotiline 69.64 µM -1.55370682648671 0.0828778223709856 no 3068 0.0601271819981283 4465 4011 A tricyclic antidepressant. SGTC_2056 5235370 200 µM -1.55444576148723 0.0827828752924494 no 3069 0.0600390624057379 4437 5511916 SGTC_193 1273-0060 1.558 µM -1.55708359375398 0.0824446030487296 no 3070 0.0597253198509823 4377 2847393 YHR072W ERG7 SGTC_650 1328-0195 38 µM -1.55721128722917 0.0824282542481825 no 3071 0.0597101647062745 4533 2780821 SGTC_1172 0370-0043 85 µM -1.55889616131903 0.0822127656437235 no 3072 0.0595104795220195 4547 376585 SGTC_852 0418-0143 439 µM -1.56187523666079 0.0818327926955312 no 3073 0.0591586916083912 4511 5369229 SGTC_3297 9117502 71.43 µM -1.56271337636982 0.0817261292039006 no 3074 0.05906001335787 4548 7453720 SGTC_3029 9088683 49.47 µM -1.56925285487837 0.080897497060518 no 3075 0.0582945164330261 4533 25236615 SGTC_713 1488-1073 324 µM -1.57743312091225 0.0798699056522869 no 3076 0.0573479497188729 4576 3312542 SGTC_62 0180-0423 3.232 µM -1.58118720227776 0.0794016419278078 no 3077 0.056917620327356 4489 30102 YGL099W LSG1 SGTC_511 blebbistatin 171 µM -1.58762197568241 0.0786038409228112 no 3078 0.0561859229363787 4582 3476986 A myosin inhibitor. SGTC_2747 doxorubicin 7.63 µM -1.59330352549769 0.0779044902112448 no 3079 0.0555460580923434 4603 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_687 k029-0044 34.9 µM -1.59731165351251 0.0774139711191724 no 3080 0.0550981272142664 4597 5829338 SGTC_2228 7354201 200 µM -1.59902594466328 0.0772048919048279 no 3081 0.054907418949093 4638 753451 SGTC_2893 9048488 25.97 µM -1.60521878958292 0.0764531705762322 no 3082 0.0542228319124461 4572 6467338 SGTC_1173 0443-0020 122 µM -1.60741090597518 0.0761884181143083 no 3083 0.0539821296285228 4542 5331295 SGTC_2794 7785382 27.27 µM -1.60938088259786 0.0759510903916889 no 3084 0.0537665414510575 4537 2205081 SGTC_747 3448-8087 38.7 µM -1.60938922701097 0.0759500863192158 no 3085 0.0537656297165428 4589 5168703 SGTC_936 3005-4620 401 µM -1.61123290582092 0.0757284865554866 no 3086 0.053564484114335 4556 777207 SGTC_1001 4048-4355 44.4 µM -1.61214748406393 0.0756187423418093 no 3087 0.0534649249680446 4546 21824233 SGTC_1044 1222-0021 1.78 µM -1.62438226006131 0.0741622675771581 no 3088 0.0521471253977271 4473 4306703 SGTC_1491 4138-0063 26.5 µM -1.62452028125059 0.0741459601025874 no 3089 0.0521324077437867 4574 23883227 SGTC_1946 st076057 65.1 µM -1.63019900916877 0.0734773792513241 no 3090 0.0515297216405621 4553 953009 SGTC_3032 9089427 49.47 µM -1.63202956127359 0.0732628460503258 no 3091 0.0513366294608696 4529 17173707 SGTC_2035 5154463 94.595 µM -1.63344381216966 0.0730974300152644 no 3092 0.0511878444581177 4572 2769623 SGTC_2243 6634756 200 µM -1.63380518127867 0.0730552088219131 no 3093 0.0511498820322977 4581 885676 SGTC_438 sphingosine 6.67 µM -1.6372961021081 0.072648301433236 no 3094 0.0507843074934975 4495 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2164 5685496 200 µM -1.63761199334981 0.0726115664471001 no 3095 0.0507513297934424 4494 759046 SGTC_976 1348-1067 47.6 µM -1.63812270421756 0.0725522059859759 no 3096 0.0506980498282732 4576 5310671 YGL099W LSG1 SGTC_1105 epirubicin 18.1 µM -1.63950563457139 0.0723916531400647 no 3097 0.0505539990834865 4599 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1525 8-methoxypsoralen 92.5 µM -1.63982037522716 0.0723551510273639 no 3098 0.0505212602129412 4581 4114 Related to psoralen; DNA damaging agent. SGTC_1086 cerivastatin 2.18 µM -1.64048554485285 0.07227805424144 no 3099 0.0504521257935821 4578 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_158 k038-0087 26.446 µM -1.64102050121554 0.0722160955696456 no 3100 0.0503965797981431 4472 X158 SGTC_785 1270-0111 65.3 µM -1.6416708348982 0.0721408287231103 no 3101 0.0503291194976025 4482 6741994 SGTC_3034 9090421 49.47 µM -1.65307444157249 0.0708307749825516 no 3102 0.0491578571125902 4508 17173761 SGTC_1923 st058458 19.1 µM -1.65536736387486 0.0705695833912957 no 3103 0.0489250009704315 4548 3534982 SGTC_869 0564-0080 44.1 µM -1.65683281512698 0.0704030389384495 no 3104 0.0487766402860699 4561 6843321 SGTC_183 3914-0051 30.55 µM -1.65716780876066 0.0703650103145635 no 3105 0.0487427764390484 4567 1596232 SGTC_1955 wogonin 32.4 µM -1.65811522437374 0.0702575447787261 no 3106 0.0486471057756682 4545 5281703 A flavanone. SGTC_2597 laccaic acid a 100 µM -1.65886791877464 0.0701722565180527 no 3107 0.048571205245842 4539 5491415 A textile dye. SGTC_1507 4075-3230 155 µM -1.67112796172777 0.0687942502091833 no 3108 0.0473482027110338 4538 659771 SGTC_963 1269-2853 151 µM -1.67374600556583 0.068502708525752 no 3109 0.0470902640163778 4574 3668223 SGTC_2458 5808907 16.39 µM -1.67478051465085 0.0683877701141434 no 3110 0.0469886516652152 4673 2731747 SGTC_2586 curcumin 80 µM -1.67566452552909 0.0682896706538366 no 3111 0.0469019610487527 4467 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3040 9091894 49.47 µM -1.67622448641831 0.068227587506541 no 3112 0.0468471148195182 4492 25236966 SGTC_281 1672-3440 14.9 µM -1.6797145156275 0.0678416275625724 no 3113 0.0465064370920752 4615 6833000 SGTC_2567 aureobasidin a 60 nM -1.68010157541192 0.067798926970272 no 3114 0.0464687772202306 4631 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1637 st007924 17.4 µM -1.69459419092826 0.0662149892268448 no 3115 0.0450762149120933 4505 683336 SGTC_3277 9138724 49.47 µM -1.6981133040735 0.0658347346078172 no 3116 0.0447431895309258 4560 15943418 SGTC_2262 9014885 67.46 µM -1.70267147363676 0.0653447241463984 no 3117 0.0443147830886523 4637 6457424 SGTC_887 0885-0007 9.62 µM -1.70425074921614 0.0651756110156533 no 3118 0.0441671258973337 4599 5719458 SGTC_935 2996-0153 430 µM -1.70658838097222 0.0649259146679552 no 3119 0.0439492931442553 4592 23738523 SGTC_3133 9127736 49.47 µM -1.70957016587552 0.0646084910144234 no 3120 0.0436726932225835 4591 27243420 SGTC_327 1273-0057 3.96 µM -1.71179643749706 0.0643722819194393 no 3121 0.0434670944153974 4511 3108138 SGTC_1470 k295-0292 231 µM -1.7128747866613 0.0642581097652209 no 3122 0.0433677888579951 4641 5045612 SGTC_1553 gossypol 38.6 µM -1.71313551624424 0.0642305281933957 no 3123 0.0433438056975165 4552 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1705 st027868 56.3335 µM -1.71766026305091 0.0637533368723841 no 3124 0.0429293006863081 4526 292948 SGTC_1407 3909-7909 12.3 µM -1.7186862601599 0.0636455171400529 no 3125 0.042835757606018 4625 4411780 SGTC_2648 atorvastatin 78.68 µM -1.72918144845755 0.0625507338913768 no 3126 0.0418883127613945 4602 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1406 3909-7906 11.9 µM -1.7305642963132 0.062407586293058 no 3127 0.0417647521441583 4625 X1406 SGTC_323 4013-0906 34.3 µM -1.73161961302137 0.0622985155362474 no 3128 0.0416706559049511 4619 2910086 SGTC_1165 k072-0275 30.3 µM -1.73455483738608 0.061995931347539 no 3129 0.041409842378264 4603 6153523 YGL055W OLE1 SGTC_3216 9129716 49.47 µM -1.73512076099748 0.0619377239325694 no 3130 0.0413597088753336 4513 8056934 SGTC_480 am 92016 50 µM -1.74738456868353 0.0606867922619554 no 3131 0.0402853262020603 4617 2129 K+ channel blocker. SGTC_1808 st050063 61.5 µM -1.75028280013663 0.0603940735971536 no 3132 0.0400347636631886 4561 4011993 SGTC_339 3091-4833 71.4 µM -1.75068434775289 0.0603536049571583 no 3133 0.0400001485206616 4430 3240077 SGTC_1689 st020265 53.493 µM -1.75124306115767 0.0602973321974435 no 3134 0.0399520254743581 4600 5758320 YPR016C TIF6 SGTC_1215 3852-0577 11.2 µM -1.75306817189957 0.0601137959813348 no 3135 0.039795153025655 4634 2884876 SGTC_1063 disulfiram 1.84 µM -1.75525019928725 0.0598949420241217 no 3136 0.039608260378503 4632 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_877 0771-0151 33.1 µM -1.7553905363285 0.0598808878244626 no 3137 0.0395962648538031 4621 6166523 SGTC_1732 st034308 51.822 µM -1.76064422718763 0.0593566075258301 no 3138 0.0391493190052016 4500 830119 SGTC_845 0330-0138 4.51 µM -1.76113776863825 0.0593075411617601 no 3139 0.0391075439338139 4576 9039800 SGTC_2157 5649910 96.377 µM -1.76292022027618 0.0591306001255091 no 3140 0.0389569730929141 4595 2858091 SGTC_739 1486-1183 203 µM -1.76392929230845 0.0590306149080118 no 3141 0.0388719422091998 4605 4346692 SGTC_2101 5377231 179.231 µM -1.77157731875622 0.0582771064153029 no 3142 0.0382323737388196 4633 2844213 SGTC_2650 prasterone 100 µM -1.77242103438185 0.0581944456261608 no 3143 0.0381623463460517 4643 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_287 k060-0039 29.6 µM -1.78599318009283 0.0568773712290819 no 3144 0.0370501811911066 4654 5861974 SGTC_1880 MG-132 525 µM -1.78740373992614 0.0567418445651373 no 3145 0.0369361288010748 4588 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1929 genistein trimethyl ether 50.5 µM -1.78825650100876 0.0566600346912733 no 3146 0.0368673171772876 4579 136420 SGTC_1985 st071382 65.5 µM -1.79465042171273 0.0560495890460532 no 3147 0.0363547071343078 4621 6123237 SGTC_1015 4130-4525 82 µM -1.79817767502339 0.0557150590114416 no 3148 0.0360744281014647 4618 1363237 SGTC_3343 9148379 18.9835 µM -1.80796470157806 0.0547950903865507 no 3149 0.0353059972636822 4641 1955036 SGTC_2146 5545642 200 µM -1.81046354431099 0.0545621370398737 no 3150 0.0351119664104379 4599 825326 SGTC_421 streptovitacin 30 mM -1.81245260300694 0.0543772684475938 no 3151 0.0349581455847853 4603 91467 include heat shock SGTC_2568 diosmetin 100 µM -1.8142695689139 0.0542088280143588 no 3152 0.03481811709892 4626 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_705 1124-0212 310 µM -1.81671587247591 0.053982697780444 no 3153 0.034630315037407 4619 9554485 SGTC_3010 9080089 71.4286 µM -1.81711106683821 0.0539462371560233 no 3154 0.0346000542749777 4632 17027233 SGTC_599 1935-0052 86.5 µM -1.81850302828988 0.053817970066977 no 3155 0.0344936421454755 4624 9557311 SGTC_811 0416-0114 265 µM -1.82534570090825 0.0531909364651204 no 3156 0.0339744388749215 4631 6612453 SGTC_356 1634-0012 32.5 µM -1.82926383463632 0.0528345113387292 no 3157 0.0336800468387457 4637 735457 SGTC_3127 9126946 49.47 µM -1.8301872271201 0.0527507885811432 no 3158 0.03361097354553 4591 27243249 SGTC_1369 1866-0067 208 µM -1.84179969045146 0.0517068635654357 no 3159 0.032752227685158 4639 3531355 SGTC_414 piperonyl butoxide 100 µM -1.84235905950014 0.0516569955813082 no 3160 0.0327113230765794 4641 5794 A potent inhibitor of cytochrome P450. SGTC_2429 5902844 64.44 µM -1.84277282982458 0.0516201323920414 no 3161 0.0326810926807797 4629 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2476 5806916 10.51 µM -1.84328024222725 0.0515749550952362 no 3162 0.0326440521708493 4589 2870194 SGTC_2048 5246248 200 µM -1.84508534071557 0.0514144935454955 no 3163 0.0325125626522416 4661 677046 SGTC_3337 9144342 33.5465 µM -1.84543053294248 0.0513838534688402 no 3164 0.0324874675049274 4643 17682949 SGTC_2890 9046729 58.44 µM -1.84845360452159 0.051116138657291 no 3165 0.0322683751057263 4623 903329 SGTC_3059 1327-0034 3 µM -1.84860945047146 0.0511023675161361 no 3166 0.0322571135465476 4508 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2799 7812892 81.82 µM -1.84943190444075 0.0510297412520555 no 3167 0.0321977360493924 4641 20205235 SGTC_1336 1486-0901 104 µM -1.85430316078026 0.0506012708580585 no 3168 0.0318479000933172 4650 5006114 SGTC_1450 4112-4260 37.6 µM -1.86069116114038 0.0500437378354759 no 3169 0.0313939013876091 4645 1633175 SGTC_279 1273-0055 2.93 µM -1.86226247188826 0.0499073500382927 no 3170 0.0312830512505525 4688 2847562 SGTC_1688 st021091 57.6 µM -1.87116387047646 0.0491403075953538 no 3171 0.0306611854430003 4695 3656366 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.87689741478 0.0486512481204579 no 3172 0.0302660776373474 4682 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2994 9053520 71.4286 µM -1.88054830722386 0.0483418674809576 no 3173 0.0300166946044353 4642 4647384 SGTC_1787 fluconazole 80 µM -1.88077990989557 0.0483222944186421 no 3174 0.0300009320680542 4293 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1635 st007035 42.4 µM -1.88314090545019 0.0481231249130341 no 3175 0.0298406374919114 4612 3716403 SGTC_587 k089-0003 57 µM -1.89663674083374 0.0469972173427997 no 3176 0.0289379489961568 4604 9659696 SGTC_889 0919-1524 82.7 µM -1.90382573838927 0.0464061455140953 no 3177 0.0284664416294162 4681 3905452 SGTC_1698 5-fluorocytosine 1.055 µM -1.90512253389083 0.0463001623971555 no 3178 0.0283820724396493 4661 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1383 3049-0032 20.7 µM -1.9113481843642 0.0457940623300637 no 3179 0.0279799253770362 4679 712864 SGTC_1475 4092-1048 11.7 µM -1.91223270986657 0.0457225189332141 no 3180 0.0279231761780084 4663 2881759 SGTC_3063 1327-0034 4 µM -1.91335398024161 0.0456319559735639 no 3181 0.0278513757813475 4541 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2625 euphol 100 µM -1.91715821096907 0.0453257693627231 no 3182 0.0276089176125738 4656 6708538 A triterpene alcohol. SGTC_2505 galangin 7.89 µM -1.92580227925652 0.0446361871634594 no 3183 0.0270645333843109 4628 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2057 5236571 38.335 µM -1.92780121263291 0.0444779309254703 no 3184 0.0269399284209654 4605 54684039 YBR257W POP4 SGTC_648 0375-0473 33.3 µM -1.92793156225841 0.0444676268216921 no 3185 0.0269318196417203 4655 1713139 SGTC_1924 st058459 75.1 µM -1.92817610803192 0.0444483007311855 no 3186 0.0269166124541572 4637 688683 SGTC_3106 9121286 49.47 µM -1.93568918892703 0.0438578436966592 no 3187 0.0264528896756169 4614 15943471 SGTC_2518 prenyletin 46.28 µM -1.9398399824299 0.0435343538397546 no 3188 0.0261995699445023 4704 3873459 A coumarin with calcium channel inhibitory activity. SGTC_521 r062-0005 13.8 µM -1.94194349819394 0.0433711542698587 no 3189 0.0260719703745865 4603 2832033 SGTC_118 0083-0097 135.343 µM -1.95138441537559 0.0426447620115944 no 3190 0.0255056669844867 4643 5207356 SGTC_210 3551-0445 56.827 µM -1.95286447600976 0.0425317819036474 no 3191 0.025417828024963 4645 2865180 YOR207C RET1 SGTC_2546 rhodinyl acetate 100 µM -1.95592710776131 0.0422987652249836 no 3192 0.0252368707437607 4629 6708682 SGTC_1921 5740136 50 µM -1.95618655920791 0.042279072718207 no 3193 0.0252215906352032 4603 1774243 SGTC_3157 9099274 49.47 µM -1.96161588503949 0.0418686829281593 no 3194 0.0249036107261845 4673 17217662 SGTC_1987 st072290 61.9 µM -1.96412834719009 0.0416798666222487 no 3195 0.0247576047968364 4682 54697379 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.97118020991223 0.0411535881682885 no 3196 0.0243516333562219 4640 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_663 1486-0733 13.9 µM -1.97157487521855 0.0411242943508249 no 3197 0.0243290788504656 4686 722445 YPR165W RHO1 SGTC_111 0083-0039 52.457 µM -1.97289169416455 0.0410266764827041 no 3198 0.0242539515639393 4659 759313 SGTC_2331 7980721 200 µM -1.98463055373647 0.0401647365960614 no 3199 0.0235927952043339 4641 2981221 SGTC_2630 antimycin a 100 µM -1.98499736254996 0.0401380420732859 no 3200 0.0235723824681825 4607 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1607 st000305 50.6 µM -1.99328672717112 0.0395386171073865 no 3201 0.0231150294799866 4679 5457690 SGTC_2645 abamectin 100 µM -1.99757936553481 0.0392310789067212 no 3202 0.0228811410840926 4664 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1930 st074634 34.3 µM -2.00760721722319 0.0385202342265041 no 3203 0.0223425235127303 4619 684253 YOR116C RPO31 SGTC_3020 9089140 49.47 µM -2.00764676375635 0.038517451810423 no 3204 0.0223404207408151 4687 17217859 SGTC_3068 9116768 49.47 µM -2.01130980619159 0.0382604367533669 no 3205 0.0221463716788289 4648 41904888 SGTC_450 aminopyrene 156 nM -2.02839031037635 0.0370803957193874 no 3206 0.0212602141250275 4659 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2176 5809774 33.9695 µM -2.03026179875947 0.0369529281327489 no 3207 0.0211649675434848 4634 2870539 SGTC_3251 9135047 49.47 µM -2.03961198381672 0.03632143966182 no 3208 0.0206944937552575 4728 17682963 SGTC_297 0986-0032 24 µM -2.04548790714726 0.0359291336049654 no 3209 0.0204033901081276 4683 2847425 SGTC_2329 6138490 200 µM -2.05116645165081 0.0355533104071742 no 3210 0.0201253698803175 4666 720019 SGTC_2126 5251174 33.877 µM -2.05555309352874 0.0352652007701427 no 3211 0.0199128065151462 4661 790722 SGTC_621 3584-0052 32.1 µM -2.05590515566552 0.0352421609894938 no 3212 0.0198958295395129 4719 2273927 SGTC_1052 3253-3998 198 µM -2.05826179374619 0.035088254783915 no 3213 0.0197825048174843 4667 5450317 SGTC_2621 lithochol-11-enic acid 100 µM -2.05876908011865 0.0350551974072188 no 3214 0.0197581825015337 4646 6708711 SGTC_117 lucigenin 22.078 µM -2.05956019599524 0.0350036952580818 no 3215 0.019720302379162 4653 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_501 nsc-95397 161 µM -2.06247161544476 0.0348146945201916 no 3216 0.0195814286139423 4692 262093 SGTC_1571 st070080 73.4 µM -2.06953344125475 0.0343597407577646 no 3217 0.0192480282890266 4683 4315245 SGTC_588 3970-1144 52.9 µM -2.07313233450817 0.0341297704080688 no 3218 0.0190799827641855 4638 1888707 SGTC_1773 st048542 73.5835 µM -2.07937794150028 0.0337336786816155 no 3219 0.018791313169464 4690 3237138 SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.08329930054041 0.0334869275654713 no 3220 0.0186119752327529 4708 140250 A respiratory chain inhibitor. SGTC_1042 0350-0096 82 µM -2.08646323438623 0.0332889221466352 no 3221 0.0184683410983264 4690 3122515 SGTC_1554 st069299 38.7 µM -2.10228120949068 0.032313410721732 no 3222 0.0177643248009495 4675 24207999 SGTC_1170 0310-0127 64.8 µM -2.10444467720332 0.0321818400032445 no 3223 0.0176698378315781 4707 774975 SGTC_2834 9001755 58.44 µM -2.11068728367179 0.0318046745020064 no 3224 0.0173995998586686 4574 2989575 SGTC_871 0574-0004 149 µM -2.12332579107 0.0310522584688203 no 3225 0.016863280461129 4678 9551173 SGTC_840 0245-0196 390 µM -2.1252146433792 0.0309410836102658 no 3226 0.0167843533572432 4751 3827528 SGTC_716 1683-5115 658 µM -2.13357353786998 0.0304530397081847 no 3227 0.0164388530201135 4702 723597 SGTC_1023 4482-3888 16 µM -2.14263753655676 0.0299310522883977 no 3228 0.0160711073055697 4699 3303168 SGTC_895 0964-0006 13.7 µM -2.14698092689595 0.0296835627600034 no 3229 0.0158974000431097 4716 6738897 SGTC_1081 sertraline 6 µM -2.14904782949165 0.0295663868309288 no 3230 0.0158153043414062 4697 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1764 st044502 93.5 µM -2.16384024150276 0.0287389413222514 no 3231 0.0152383062643533 4735 8407 SGTC_110 0850-0284 111.64 µM -2.16596398017665 0.0286217413108155 no 3232 0.0151569697599209 4703 3906265 SGTC_878 0828-0289 13.7 µM -2.17572801731953 0.0280880095258531 no 3233 0.0147878019630523 4704 745350 YLR208W SEC13 SGTC_1875 nocodazole 6 µM -2.1862814654782 0.0275204720234447 no 3234 0.0143975096477957 4742 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_95 0471-0001 561.058 µM -2.19026268564972 0.027308870541071 no 3235 0.0142525956775742 4698 4015405 SGTC_2143 5623677 140.463 µM -2.19850381847001 0.0268751652651301 no 3236 0.0139566113733429 4709 5375313 SGTC_1540 guanosine 70.6 µM -2.20404040736897 0.0265870331218487 no 3237 0.0137607512420014 4706 6802 Guanosine is a purine nucleoside SGTC_57 miconazole 162.5 nM -2.20620109500403 0.0264752900463901 no 3238 0.0136849613256542 4598 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2373 9071805 200 µM -2.21104184361062 0.0262263677169406 no 3239 0.0135164697901147 4720 10149009 SGTC_2411 st077133 39.94 µM -2.21682629068169 0.0259314873676935 no 3240 0.0133174821058761 4684 1403142 YNL221C POP1 SGTC_2363 9053361 176 µM -2.22085752466026 0.0257276269056166 no 3241 0.0131803064555326 4714 6469797 YMR079W SEC14 SGTC_1286 0929-0070 131 µM -2.23039212483043 0.0252507933169944 no 3242 0.0128607109676913 4749 1420408 SGTC_1968 st069590 43.6 µM -2.23158862428135 0.0251914816346142 no 3243 0.0128210820884277 4707 6384066 SGTC_369 0957-0393 4.5 µM -2.24403470904467 0.0245814113551081 no 3244 0.0124150841092648 4714 6997992 SGTC_2079 5212404 121 µM -2.25501384067497 0.0240535856834913 no 3245 0.0120662300195258 4700 758462 SGTC_1388 3346-4487 254 µM -2.26403740569171 0.0236269343377662 no 3246 0.0117859071220544 4741 3345614 SGTC_960 1222-0186 7.7 µM -2.26977358119117 0.023359039853616 no 3247 0.0116106621455156 4717 3126296 SGTC_3287 9117173 37.0625 µM -2.27688185714523 0.0230306155300877 no 3248 0.0113966407917641 4749 2789709 SGTC_2884 9058502 51.95 µM -2.28201854574809 0.022795712531503 no 3249 0.0112441226762188 4721 6471554 SGTC_1368 1852-0141 284 µM -2.28598012582487 0.0226159296072671 no 3250 0.011127710635195 4691 2838987 SGTC_3200 9114385 49.47 µM -2.29282144734539 0.0223082738293282 no 3251 0.0109291433613128 4694 17018030 YLR208W SEC13 SGTC_2320 7373003 200 µM -2.30003593264923 0.0219876691794436 no 3252 0.0107230921982247 4706 5415828 SGTC_2282 7944268 200 µM -2.30410018474613 0.0218087769231764 no 3253 0.0106085101927601 4715 2970414 SGTC_2513 baicalein 25.65 µM -2.31676318017406 0.0212592651059606 no 3254 0.0102583178885275 4719 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1370 2001-0092 44.6 µM -2.32202616114175 0.0210343469019423 no 3255 0.0101157635041957 4690 790957 SGTC_2808 7946468 45.46 µM -2.3248699394381 0.0209136556889006 no 3256 0.0100394579018599 4717 2970879 SGTC_1676 st018489 23.4 µM -2.32661999751964 0.0208396741995728 no 3257 0.0099927496216178 4712 3696235 SGTC_1404 3909-7820 48.3 µM -2.33743085395916 0.0203875540825953 no 3258 0.00970839619589454 4747 23741373 SGTC_1634 st006576 41 µM -2.33999799330139 0.02028142380184 no 3259 0.00964192175156601 4717 3915356 SGTC_2430 5571206 200 µM -2.36241502140958 0.0193744077717446 no 3260 0.00907815173986678 4715 1731771 SGTC_97 0535-0701 19.132 µM -2.37025849734651 0.0190653000595876 no 3261 0.00888782623269996 4683 2832013 YGL099W LSG1 SGTC_780 0109-0199 192 µM -2.37116523363778 0.0190298379075524 no 3262 0.00886605094119051 4751 610414 SGTC_1169 aniline yellow 25.8 µM -2.37583060068479 0.018848262518368 no 3263 0.00875474960330508 4730 6051 A DNA damaging agent. SGTC_1718 roemerine 11.9335 µM -2.3794299595107 0.0187091852145632 no 3264 0.00866971892532122 4420 235224 An aporphine alkaloid with mutagenic activity. SGTC_3232 9132874 49.47 µM -2.40410636371398 0.0177790257784843 no 3265 0.0081060277554507 4745 3784940 SGTC_2158 5657123 3.6195 µM -2.40646527571466 0.0176922106964992 no 3266 0.00805386762523396 4762 2858827 SGTC_2914 7968218 45.32 µM -2.41428331162431 0.0174070649467125 no 3267 0.00788309888617142 4736 2977111 SGTC_116 0155-0182 31.788 µM -2.41972011712034 0.0172110909236697 no 3268 0.00776622847444488 4668 771486 SGTC_903 1134-0042 114 µM -2.4230492899383 0.0170920212210513 no 3269 0.00769541913390892 4755 701009 SGTC_284 0988-0104 32.6 µM -2.46819046411643 0.0155457527778576 no 3270 0.00678990211525909 4741 4666532 SGTC_1140 3229-1848 2.98 µM -2.46891098882622 0.0155220788713795 no 3271 0.00677624623874835 4749 2849525 SGTC_2894 9048625 32.47 µM -2.47225720985339 0.0154125389513136 no 3272 0.00671314389649851 4756 4092861 SGTC_131 0141-0277 33.849 µM -2.47656521019433 0.0152724925614956 no 3273 0.0066326694960193 4726 1547771 SGTC_112 phenothiazine 287.218 µM -2.48697713877849 0.0149385226026388 no 3274 0.00644168388380326 4742 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1522 st012842 45.6 µM -2.48710604035881 0.014934427654673 no 3275 0.00643935025914482 4660 3491067 YOR116C RPO31 SGTC_48 0382-0018 55 µM -2.48905072279226 0.0148727659482024 no 3276 0.00640423452705686 4755 762596 SGTC_459 nigericin 15.3 µM -2.49303550668825 0.0147471005760871 no 3277 0.00633280899685553 4765 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_778 3456-2434 196 µM -2.49813327068528 0.0145876683572224 no 3278 0.0062424623685961 4704 5539063 SGTC_1602 st001878 87.6 µM -2.51826414514849 0.0139724874605705 no 3279 0.00589674195862346 4749 595405 YLR310C CDC25 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -2.52057594172314 0.0139032936769558 no 3280 0.0058581476732136 4767 94937 An inhibitor of serotonin biosynthesis. SGTC_2047 4141938 200 µM -2.53254454685279 0.0135497697457433 no 3281 0.00566189901376284 4777 3807862 SGTC_2639 lactacystin 53 µM -2.53266770208877 0.0135461727420739 no 3282 0.00565991035540336 4759 3870 A proteasome inhibitor. SGTC_1652 st011932 78 µM -2.53688634629827 0.0134234551825103 no 3283 0.00559216287384065 4751 1551076 SGTC_517 1365-0151 113 µM -2.54061316827037 0.0133158441675721 no 3284 0.00553291377418276 4734 768657 SGTC_3269 9137823 49.47 µM -2.54572527479098 0.0131694459590264 no 3285 0.00545254872185785 4737 17682936 SGTC_307 1501-1223 22.3 µM -2.55633411910812 0.0128700671607957 no 3286 0.00528907465922828 4774 2830329 SGTC_393 acivicin 6.25 µM -2.55848731049227 0.0128100284957438 no 3287 0.00525643284406293 4687 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1456 k015-0012 13 µM -2.56582065607123 0.0126073628009956 no 3288 0.00514660165609408 4765 2989616 SGTC_1552 6-methylflavone 10.6 µM -2.57677246939811 0.0123098653714333 no 3289 0.0049863786190336 4764 689013 SGTC_236 1509-0011 5.31 µM -2.58135336038529 0.0121872445878087 no 3290 0.0049206895558482 4769 3107280 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -2.60046140237884 0.0116871113915653 no 3291 0.00465492456734181 4775 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1895 st058434 18.3 µM -2.61048717443524 0.011431895614322 no 3292 0.00452066810910228 4774 5393175 SGTC_1993 st073995 70.8 µM -2.61974542339088 0.0112005318854893 no 3293 0.0043997714766211 4770 3098394 SGTC_3151 9099821 49.47 µM -2.63207571357997 0.0108987256783176 no 3294 0.00424324740868517 4745 17174189 SGTC_2763 lisinopril 49.32 µM -2.64487566651584 0.0105929347345473 no 3295 0.00408604692562785 4739 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_4 0960-0234 25.671 µM -2.64697285993009 0.0105435519800992 no 3296 0.00406079354018703 4714 6821112 SGTC_1827 berberine 7.24 µM -2.64912830527876 0.0104930066941667 no 3297 0.00403498438384035 4715 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1796 st049173 110.4 µM -2.65039830506521 0.0104633241096785 no 3298 0.00401984633907509 4769 94134 SGTC_530 4358-1714 28 µM -2.6552125162397 0.0103514692472885 no 3299 0.00396292293888353 4765 1564641 SGTC_2186 6124449 200 µM -2.69032766302835 0.00956666953421878 no 3300 0.00356909466939903 4785 3834182 YLR033W RSC58 SGTC_2255 7941087 197.44 µM -2.69768867680223 0.00940891334327071 no 3301 0.0034911352421351 4781 935561 SGTC_265 mycophenolic acid 32.932 µM -2.70286720506201 0.00929929853150567 no 3302 0.00343721024210738 4785 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1844 rapamycin 4 nM -2.70601636262104 0.00923318751806654 no 3303 0.00340478453137539 4656 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_362 0310-0100 9.03 µM -2.72007450781347 0.00894305316018413 no 3304 0.00326336041232778 4772 790235 SGTC_1786 berberine 21.6 µM -2.73937169135895 0.00855781540603433 no 3305 0.00307783684982742 4719 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2563 tomatine 8.54 µM -2.74189070240674 0.008508617358446 no 3306 0.0030543332129074 4736 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1998 st075797 76.8 µM -2.75511595704216 0.0082543698314972 no 3307 0.00293356688960439 4778 24208315 SGTC_1208 2323-2347 50.3 µM -2.775070893126 0.00788337737019975 no 3308 0.00275948379933282 4781 5412760 SGTC_1751 st044839 27.194 µM -2.82095982366373 0.00708537687622243 no 3309 0.00239400994849477 4791 5291326 SGTC_3204 9114183 49.47 µM -2.82157250742487 0.00707522313083029 no 3310 0.00238944165782152 4743 17027248 SGTC_682 0kpi-0099 17 µM -2.83241935205745 0.00689757676053175 no 3311 0.0023098609063089 4780 1714895 YML126C ERG13 SGTC_1790 st045711 43.5 µM -2.83986317334309 0.00677795432831131 no 3312 0.0022566443951882 4788 585119 SGTC_3339 9145883 14.936 µM -2.84521030649603 0.00669316060149553 no 3313 0.0022191054782645 4766 2030670 SGTC_2638 epoxomicin 18 µM -2.86521016559375 0.00638426010000953 no 3314 0.00208366281182463 4769 9915668 A protesome inhibitor. SGTC_617 3770-0098 35 µM -2.89524996575311 0.00594398617369079 no 3315 0.00189428356672194 4754 5962639 SGTC_2805 7950783 58.44 µM -2.90464408912588 0.00581194062646078 no 3316 0.00183835462813613 4771 1178958 YDL195W SEC31 SGTC_784 4579-0127 173 µM -2.9068171310024 0.00578176913026543 no 3317 0.00182563290527843 4790 1948547 SGTC_385 1494-0393 12.4 µM -2.90684051035181 0.00578144527793384 no 3318 0.00182549647100599 4784 3090647 SGTC_779 1360-0071 233 µM -2.91044279875442 0.00573173803877988 no 3319 0.00180458512353132 4784 7566 SGTC_1498 4478-3555 97.6 µM -2.92061626081179 0.00559339881663338 no 3320 0.00174669913034045 4796 3437919 SGTC_23 0213-0011 39.996 µM -2.92983693883295 0.00547058586048825 no 3321 0.00169569958289371 4778 627608 SGTC_2679 rapamycin 1 nM -2.93544091991171 0.00539712097214445 no 3322 0.00166537015684197 4691 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_567 1080-0542 68.4 µM -2.95375405562483 0.00516312476083066 no 3323 0.00156967043919367 4758 5950415 SGTC_585 0kpi-0023 191 µM -2.95841560252283 0.0051050224398781 no 3324 0.00154612452431953 4773 64601 SGTC_1323 1348-1351 11.2 µM -2.96084519060438 0.00507497098306239 no 3325 0.00153398053499809 4778 6989654 SGTC_135 0933-0004 26.348 µM -3.00725772893516 0.00453035777227001 no 3326 0.00131808079628291 4762 21230617 YGL099W LSG1 SGTC_1851 st056236 18.9 µM -3.10517889100482 0.0035491480927336 no 3327 0.00095081987379022 4785 5393171 SGTC_3105 9121040 49.47 µM -3.13145291303266 0.00332061912940489 no 3328 0.000869718385124056 4795 41448907 SGTC_451 chloral hydrate 100 µM -3.16855239302361 0.00302045010246617 no 3329 0.000766000668252091 4792 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1141 3253-0389 52.6 µM -3.17085239467901 0.00300267185184815 no 3330 0.000759961767807527 4784 5402031 SGTC_1335 1486-0900 202 µM -3.2038791899597 0.00275757762969529 no 3331 0.000677946794752804 4800 X1335 SGTC_3295 9122362 53.5725 µM -3.21509238751706 0.0026785635128742 no 3332 0.00065201272871108 4795 4730473 SGTC_2462 5162487 171.77 µM -3.27067186169866 0.00231629329635995 no 3333 0.000536461631806685 4797 2259986 SGTC_3108 9121785 49.47 µM -3.28435566403371 0.00223419662195802 no 3334 0.000511079198307706 4773 17140271 SGTC_2066 5222451 176 µM -3.28879531666044 0.00220813274609624 no 3335 0.000503085834249009 4785 2281147 SGTC_940 3232-1287 54.8 µM -3.33390242524397 0.00195852562291339 no 3336 0.000428183466702454 4792 1585493 YIL048W NEO1 SGTC_1611 st001856 99.4 µM -3.37093047349672 0.00177309029042485 no 3337 0.000374573809970699 4807 647478 SGTC_2828 7998861 71.43 µM -3.38945002680296 0.00168646947416877 no 3338 0.000350164862284621 4804 2988188 SGTC_2570 licareol 100 µM -3.41809305749556 0.00156006481696919 no 3339 0.000315307709234869 4789 443158 SGTC_569 4130-2812 160 µM -3.45547280349005 0.00140810037236822 no 3340 0.000274664303581205 4792 743552 SGTC_2325 6158266 200 µM -3.45553470157385 0.00140786035149605 no 3341 0.000274601245711058 4790 3623240 SGTC_1878 temozolomide 1 mM -3.48433016747976 0.00130016686543034 no 3342 0.00024668523099919 4802 5394 DNA alkylating agent. SGTC_3142 9086498 49.47 µM -3.61432621815245 0.000901612754459617 yes 3343 0.000150564858194846 4765 25236367 SGTC_941 3237-0776 460 µM -3.66466293539167 0.000780113498467111 yes 3344 0.000123832266454788 4800 760008 SGTC_2806 7952793 58.44 µM -3.69124395718045 0.000722218326538717 yes 3345 0.000111579984236617 4786 2972490 SGTC_386 1509-0011 3.07 µM -3.70735660215685 0.000689079418611258 yes 3346 0.000104716967907488 4804 3107280 SGTC_84 0443-0269 128.823 µM -3.70952544748254 0.000684727435703426 yes 3347 0.000103824043412809 4800 6150058 SGTC_73 0327-0325 16.231 µM -3.73739747101694 0.000631010736233679 yes 3348 9.29674355211766e-05 4756 53298 SGTC_1268 0828-0275 2.46 µM -3.80058789850816 0.000523318704714667 yes 3349 7.2176600347876e-05 4806 745337 SGTC_513 4245-1575 41.7 µM -3.99575185410019 0.000288721118629639 yes 3350 3.22446283025021e-05 4771 719745 SGTC_280 3448-3607 3.04 µM -4.01988953009709 0.00026777344495632 yes 3351 2.91127185606809e-05 4796 626179 SGTC_894 0960-0238 55.9 µM -4.06968902078886 0.000228952742791074 yes 3352 2.35379662879649e-05 4794 6741907 YDL195W SEC31 SGTC_3107 9121808 49.47 µM -4.25955735081154 0.000124105248065595 yes 3353 1.024160698238e-05 4805 662681 SGTC_1727 st034309 9.9045 µM -4.2660126752627 0.000121496416180921 yes 3354 9.94987395565569e-06 4803 870305 SGTC_3136 9095672 49.47 µM -4.77210850378215 2.10511119950447e-05 yes 3355 9.11536196696354e-07 4804 17217380 SGTC_359 0081-0058 15.9 µM -5.51899938509187 1.15365393068371e-06 yes 3356 1.70467693754552e-08 4804 3494159