SGTCid condition conc unit SNM1|YDR478W.score SNM1|YDR478W.strain.pval SNM1|YDR478W.strain.significant SNM1|YDR478W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2966 9084041 48.03 µM 6.49987663018859 5.16213553780038e-10 yes 1 4.01929533167059e-11 1 17741380
SGTC_78 0336-0123 156.75 µM 5.30629686118694 3.14202707525367e-07 yes 2 5.59373536144937e-08 4 6765896
SGTC_2351 9026858 72.31 µM 4.39659395987591 1.83683287799931e-05 yes 3 5.49813858439815e-06 8 1409300
SGTC_1049 3226-0134 66 µM 4.31410043783193 2.56579869022609e-05 yes 4 8.01270416088515e-06 6 5702385
SGTC_1240 0356-0016 42.1 µM 4.13444792258072 5.20852543017019e-05 yes 5 1.7790446086806e-05 5 4305613
SGTC_2801 7907800 81.82 µM 4.05694038750291 7.0102912788181e-05 yes 6 2.48598828967926e-05 6 6620925
SGTC_3349 9149703 23.001 µM 3.94149514101129 0.0001081062900886 yes 7 4.04876378509148e-05 1 4910494
SGTC_1930 st074634 34.3 µM 3.91763452023728 0.000118066437642752 yes 8 4.47110731482251e-05 13 684253 YOR116C RPO31
SGTC_896 0964-0007 44.5 µM 3.91103990982335 0.000120967458796478 yes 9 4.59497917908736e-05 11 6756758
SGTC_2296 7971656 126.45 µM 3.8954297383703 0.000128103173519363 yes 10 4.9012387861592e-05 7 666570
SGTC_453 enantio-paf c16 10 µM 3.88161576592732 0.000134745181200202 yes 11 5.18823676718814e-05 23 13871343 A lipid and platelet activating factor
SGTC_454 lyso-paf C-16 6.67 µM 3.8630053495228 0.000144204760467441 yes 12 5.60002770944689e-05 4 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1629 st005085 44.9 µM 3.74775947432431 0.000218098769220925 yes 13 8.92106123067703e-05 14 24207091
SGTC_1126 isoteolin 1.0172 µM 3.70371820381349 0.000254709301031285 yes 14 0.000106231132124411 7 133323
SGTC_2085 5307070 144.047 µM 3.6947222603368 0.000262859699145562 yes 15 0.000110063635084571 10 2840351
SGTC_2203 7227154 166.4 µM 3.62837141436511 0.000330912608559042 yes 16 0.000142607372192105 3 896304
SGTC_1308 1187-1617 41.4 µM 3.53792492850197 0.000450250833660329 yes 17 0.000201642350262691 18 2882570
SGTC_68 0986-0284 82.829 µM 3.5165547967066 0.000483752716666555 yes 18 0.000218593203243969 16 423278 YIL048W NEO1
SGTC_1664 st014217 9.02 µM 3.47116886906436 0.000562697103801572 yes 19 0.000259099003587556 11 3982782
SGTC_2155 5570423 76 µM 3.40877925816353 0.000690737752197869 yes 20 0.000326271292217678 7 797402
SGTC_1135 dihydrocapsaicin 536.708 nM 3.38596291043556 0.000743919902189501 yes 21 0.000354644846997134 9 107982 A Capsaicinoid.
SGTC_2152 5568786 200 µM 3.38260207096754 0.000752064960117348 yes 22 0.000359012948436627 8 5399883
SGTC_400 oxethazaine 37.5 µM 3.3268315211254 0.000899790167073647 yes 23 0.000439197321782661 7 4621 A local anesthetic.
SGTC_2903 5923464 63.88 µM 3.31008590023316 0.00094909497235839 yes 24 0.000466336717831798 3 2876576
SGTC_1373 2887-0003 58.5 µM 3.28565572395763 0.0010254867624391 no 25 0.000508726420703929 23 776948
SGTC_2199 6590217 200 µM 3.26257097417536 0.00110281514289466 no 26 0.000552032614078547 7 703109
SGTC_2945 9067681 61.76 µM 3.225631963213 0.001237734353833 no 27 0.000628474375730389 8 16456930
SGTC_641 4092-0595 30 µM 3.21558045142766 0.00127697558672451 no 28 0.000650904997714567 19 786260
SGTC_2734 clemastine 41.6 µM 3.20908467478947 0.00130293697795248 no 29 0.000665791353876075 5 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2150 5556613 200 µM 3.17508538824082 0.00144686424530472 no 30 0.000748962077009146 14 743190
SGTC_2793 7325131 81.82 µM 3.15701552018674 0.00152913078809028 no 31 0.000796964312082606 15 4176441
SGTC_303 1348-1668 34.2 µM 3.13649439633971 0.00162771517687606 no 32 0.000854903521142814 11 5380509
SGTC_1697 st025554 27.742 µM 3.129696534584 0.00166162773338383 no 33 0.000874934864971752 7 1269519
SGTC_1737 st035557 69.7 µM 3.12951611544665 0.00166253649478758 no 34 0.000875472339606547 14 5716916
SGTC_157 1348-1695 65.819 µM 3.12461233481985 0.0016874105823831 no 35 0.000890197633255634 44 5380510
SGTC_1530 rhein 70.4 µM 3.09903292836709 0.00182274017233028 no 36 0.000970767201089453 8 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1242 0402-0103 60.1 µM 3.07661582484978 0.00194937538715328 no 37 0.00104682472636549 17 432868
SGTC_2468 5987765 72.9 µM 3.03018402246915 0.00223742287015387 no 38 0.0012220238711748 11 26772094
SGTC_2023 5144124 124 µM 3.0277204303724 0.00225373253411969 no 39 0.00123202965696657 16 2830192
SGTC_1721 st082152 9.2685 µM 3.01007026916486 0.00237376708599426 no 40 0.00130593627747038 23 5296051
SGTC_1886 st057356 49.9 µM 3.00837148432536 0.00238562010354222 no 41 0.00131325931911622 19 24207747
SGTC_1068 loratadine 26.9 µM 3.00420659774826 0.00241490694731104 no 42 0.00133137222468216 18 3957 A H1 histamine antagonist.
SGTC_2826 7992541 19.48 µM 3.00386582681905 0.00241731753451364 no 43 0.00133286428094829 10 2985066
SGTC_3085 9117376 49.47 µM 3.00374040924722 0.00241820527667781 no 44 0.00133341380300339 17 16480349
SGTC_3036 9090181 49.47 µM 2.97904388456449 0.00259887250511745 no 45 0.00144574681385108 10 25236586
SGTC_2957 9076800 11.52 µM 2.9635953512679 0.00271799893151936 no 46 0.00152033920626374 14 16459615
SGTC_3079 9117512 49.47 µM 2.9496320864072 0.00282989007550243 no 47 0.00159076272195445 5 7185044
SGTC_2365 9042475 200 µM 2.94807774962826 0.00284259894489564 no 48 0.00159878316612048 17 6464479
SGTC_899 1083-0020 478 µM 2.88963272747587 0.00335945559284675 no 49 0.00192846074405492 13 767123
SGTC_2731 amoxapine 43.43 µM 2.88858804980581 0.0033694171961178 no 50 0.00193487835581897 10 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2883 9059145 45.46 µM 2.8460128359234 0.00379867992260989 no 51 0.00221352051656855 21 16476510
SGTC_906 1165-0455 526 µM 2.84160587511206 0.00384580091078263 no 52 0.00224434723973594 13 3252859
SGTC_913 3487-1245 167 µM 2.83565625850379 0.00391024746815427 no 53 0.00228658188113769 24 4016153
SGTC_755 1995-0008 37.3 µM 2.82947370160004 0.00397824074198684 no 54 0.00233123158491495 10 689533
SGTC_2526 patulin 37.61 µM 2.8176755837412 0.00411093629944017 no 55 0.0024186328990736 26 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_287 k060-0039 29.6 µM 2.80786356746073 0.00422429583820889 no 56 0.00249356751266361 24 5861974
SGTC_1313 1220-0047 237 µM 2.80515766350792 0.00425604539103531 no 57 0.00251459864771471 20 3528706
SGTC_2725 haloperidol 53.21 µM 2.80204909236582 0.0042927828403364 no 58 0.00253895729079004 35 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_677 0929-0063 136 µM 2.80063794158438 0.00430955334041987 no 59 0.00255008524224798 7 1539583
SGTC_630 4356-0227 183 µM 2.79473434207073 0.00438035008163428 no 60 0.00259711897384026 28 779312
SGTC_2465 5809242 33.21 µM 2.79152280845408 0.00441929807169364 no 61 0.00262303300679771 10 2731748
SGTC_731 3966-0296 387 µM 2.79096938419597 0.00442604090694708 no 62 0.00262752213747261 10 660956
SGTC_2900 5328528 85.29 µM 2.78388473395997 0.00451317467665413 no 63 0.00268560592634711 18 795359
SGTC_1287 0971-0001 34.6 µM 2.7622147533647 0.00478927777789283 no 64 0.00287053513808 24 4665869
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.73334110676244 0.00518053140457008 no 65 0.00313476826833699 6 4620898
SGTC_1960 st011366 51.8 µM 2.72052481420824 0.00536313400446001 no 66 0.00325891899019044 22 3972846
SGTC_192 3455-0609 60.9 µM 2.69320028278129 0.00577166663049628 no 67 0.00353848712065217 19 3769639
SGTC_2071 5230951 39.92 µM 2.69171745775184 0.00579460633485646 no 68 0.0035542569567287 23 1799272
SGTC_1821 st053465 65.6 µM 2.66033875129038 0.00629938733639888 no 69 0.0039031047840791 12 675086
SGTC_3120 9124077 49.47 µM 2.65474834018774 0.00639329578651063 no 70 0.00396837975170286 18 18774327 YGL155W CDC43
SGTC_77 0828-0286 12.516 µM 2.64748582552157 0.00651714144182789 no 71 0.00405463796192029 28 745345
SGTC_2020 4017018 200 µM 2.6467298325194 0.0065301543296313 no 72 0.00406371278423553 23 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_583 1488-1091 88.9 µM 2.60803544828634 0.00722765093453411 no 73 0.0045531761747414 29 4303273
SGTC_148 3253-0744 288.01 µM 2.57330784387086 0.00790875319961045 no 74 0.00503657827692494 31 6893655
SGTC_2267 7931562 200 µM 2.56475474812965 0.00808492886223393 no 75 0.00516243777718806 29 934880
SGTC_2796 7949634 45.45 µM 2.5556232947776 0.0082768155891305 no 76 0.00529989008398679 27 2971588
SGTC_443 clozapine 122 µM 2.55316770164224 0.00832909462856177 no 77 0.00533740423748279 17 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2881 9058953 51.95 µM 2.55245914979341 0.00834423334548624 no 78 0.00534827260629413 36 17122249
SGTC_2727 riluzole 51.77 µM 2.5494973256402 0.00840777671454628 no 79 0.00539391692384644 28 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_200 k038-0079 37.545 µM 2.5436853702958 0.00853370279969786 no 80 0.00548449188259661 34 3436683
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.52955808737567 0.00884671767372399 no 81 0.0057103133965368 27 688801
SGTC_2459 5811157 9.22 µM 2.50713199710814 0.00936428426299496 no 82 0.00608576246840221 25 2870684 YBR192W RIM2
SGTC_635 k038-0028 24.7 µM 2.50547112181058 0.00940364798962784 no 83 0.00611441919928633 43 4035102
SGTC_2531 methyl deoxycholate 70.07 µM 2.49062049632888 0.00976209714719345 no 84 0.00637601235356368 32 16667744 Haematoxylin.
SGTC_925 2064-1272 59.6 µM 2.48402246885454 0.00992514600374614 no 85 0.00649538055096453 35 6815817
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.47778213119046 0.0100815384200744 no 86 0.00661009216703915 28 6708514
SGTC_1864 st057645 30.4 µM 2.46989823459391 0.0102821922986355 no 87 0.00675757468606253 21 688666
SGTC_2072 5231554 129 µM 2.46725713232097 0.0103501856253893 no 88 0.00680762739827163 24 789545
SGTC_2168 5727979 200 µM 2.45885533110808 0.0105690977023089 no 89 0.0069690385360376 30 695210
SGTC_557 1315-0110 16.2 µM 2.45757812077899 0.010602726665319 no 90 0.00699386923184052 26 6833801
SGTC_1611 st001856 99.4 µM 2.45383891680127 0.0107017163858771 no 91 0.00706701397494984 36 647478
SGTC_2286 7945697 125 µM 2.45197007547362 0.0107514920486363 no 92 0.00710382383959229 27 1245733
SGTC_1000 4048-0884 8.67 µM 2.44224733833792 0.0110137175963011 no 93 0.00729807132794854 38 13040088
SGTC_2618 avocadyne 43.43 µM 2.43579135941097 0.0111908957000569 no 94 0.00742962623582835 26 3015189
SGTC_2726 cimetidine 79.27 µM 2.42458574424331 0.0115043101953805 no 95 0.00766293184476114 18 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1442 4112-3290 3 µM 2.42328672281423 0.0115411315800863 no 96 0.00769039086968153 17 704353
SGTC_3333 9141820 12.094 µM 2.41691093120687 0.0117233441027439 no 97 0.00782642340168224 30 1939433
SGTC_2818 7996756 12.99 µM 2.40799452237957 0.0119823493661801 no 98 0.00802021084401749 27 2241621
SGTC_2733 amorolfine 100 µM 2.39422178559321 0.0123921733449803 no 99 0.00832783700047013 19 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2508 celastrol 40.54 µM 2.3928831581094 0.0124326456591331 no 100 0.00835828180036435 19 122724 Celastrol is a natural product and antioxidant.
SGTC_2441 5730946 39.09 µM 2.39225889540374 0.0124515588413456 no 101 0.00837251297232161 33 1774275
SGTC_796 1234-0020 70.7 µM 2.39132454990751 0.0124799131018815 no 102 0.008393852777072 28 46495034
SGTC_768 0384-0033 77.3 µM 2.37626330664739 0.0129447449956207 no 103 0.00874448891045065 52 3965305 YMR134W ERG29
SGTC_2366 9070441 60.58 µM 2.37372068513744 0.0130246767145886 no 104 0.00880493308140559 29 6837235
SGTC_2036 5160441 105 µM 2.37280121510903 0.0130536867140655 no 105 0.00882688106582392 59 134534 YIL048W NEO1
SGTC_2406 ethylparaben 405.7 µM 2.36139030041771 0.013418383479273 no 106 0.00910327879674349 31 8434 A possible steroid mimic.
SGTC_2185 6113692 200 µM 2.356362504527 0.013581845390238 no 107 0.00922744913363303 38 874150
SGTC_3286 9117135 37.221 µM 2.35568453015047 0.0136040184143283 no 108 0.00924430582415013 41 3438150
SGTC_1994 st072947 40.9 µM 2.35209232238315 0.0137220228659661 no 109 0.00933407043561828 34 5286565 YDL195W SEC31
SGTC_18 0111-0177 500 nM 2.34762455783579 0.0138700207230673 no 110 0.00944677741461853 34 721752
SGTC_402 epigallocatechin gallate 10 µM 2.34638652627913 0.0139112741589771 no 111 0.00947821871069281 41 65064 An antioxidant.
SGTC_479 n-linoleoylglycine 10 µM 2.328840051832 0.0145074265561002 no 112 0.00993377036614935 28 6433346 An anti-infammatory.
SGTC_3118 9124250 49.47 µM 2.32026351498965 0.0148067348524713 no 113 0.010163313267426 31 1504786
SGTC_1075 aripiprazole 15.2 µM 2.29966292553322 0.0155474407718087 no 114 0.0107336620448632 31 60795 An atypical antipschotic. YIL048W NEO1
SGTC_555 4296-0685 37 µM 2.29551464318875 0.0157003808907163 no 115 0.0108518241032557 37 2908540 YHR072W ERG7
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.28907903974214 0.0159402045036796 no 116 0.0110373802094608 23 279621
SGTC_698 k064-0052 127 µM 2.2853355581869 0.0160811453945481 no 117 0.0111465797305601 24 5088751
SGTC_201 4262-0159 12.803 µM 2.28456322375762 0.0161103560619861 no 118 0.0111692257108792 40 1341029
SGTC_343 4130-2827 29.8 µM 2.28017755885467 0.0162770910267839 no 119 0.0112985798701294 29 1118244
SGTC_1196 1588-0294 184 µM 2.27697677909111 0.0163997098684754 no 120 0.0113938061577309 29 6144269
SGTC_2773 thioridazine 9.09 µM 2.2742165882864 0.0165060844444236 no 121 0.0114764836784781 26 5452 An antipsychotic.
SGTC_642 0335-0876 158 µM 2.2739471726637 0.0165164989802358 no 122 0.0114845814793932 45 6812350
SGTC_1165 k072-0275 30.3 µM 2.26481932202509 0.0168726839014134 no 123 0.0117618846096226 44 6153523 YGL055W OLE1
SGTC_1671 st016596 74.5 µM 2.26245323705402 0.0169660777064351 no 124 0.0118347074598747 26 2829167
SGTC_449 xestospongin c 11.1929 µM 2.25844560965472 0.0171252745946998 no 125 0.0119589459583924 26 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1150 3909-7983 10.9 µM 2.25524688716325 0.0172532534189522 no 126 0.0120589181941568 58 23965914
SGTC_932 2857-0803 154 µM 2.25402564029647 0.0173023297863783 no 127 0.0120972774947621 37 674898
SGTC_1157 4092-0394 27.6 µM 2.24844465900533 0.0175281244492424 no 128 0.0122739250961468 35 3659885
SGTC_349 k015-0014 24 µM 2.24483270309025 0.0176755934281995 no 129 0.0123894372433088 38 2196908
SGTC_1013 4112-3890 241 µM 2.24389509677672 0.0177140466706839 no 130 0.0124195758543789 42 705171
SGTC_1421 4029-0249 71.4 µM 2.24326142506407 0.0177400753079659 no 131 0.0124399806682032 29 2894095
SGTC_147 4466-0538 29.23 µM 2.24063751974659 0.0178482021816706 no 132 0.0125247821460052 45 6742687 YHR072W ERG7
SGTC_1802 st050112 57.9 µM 2.23784389363359 0.0179639403353316 no 133 0.0126156184485917 30 4662563
SGTC_1293 1000-1278 195 µM 2.21886707288995 0.0187672004695768 no 134 0.0132478846061199 43 678847
SGTC_3303 9125618 40.5795 µM 2.2061094230437 0.0193242268548537 no 135 0.0136881695496479 42 22695467
SGTC_2822 7994718 71.43 µM 2.20259591014836 0.0194800795773038 no 136 0.0138116212208655 40 1018011
SGTC_3122 9126309 49.47 µM 2.2011412940271 0.0195449153991741 no 137 0.0138630113670825 47 17591206
SGTC_949 1165-0505 146 µM 2.20097161135769 0.0195524904964358 no 138 0.0138690168132951 25 6244267
SGTC_1492 4158-0558 28.5 µM 2.19944644943938 0.0196206898808925 no 139 0.0139230964551758 21 3967268
SGTC_1739 st037196 92.5 µM 2.19328764016902 0.0198981465524104 no 140 0.0141433307927622 31 612214
SGTC_2294 7971431 200 µM 2.18557598010289 0.0202502475945634 no 141 0.0144233207675197 37 5741572
SGTC_1341 1486-1360 280 µM 2.18260478728457 0.0203873097359658 no 142 0.0145324634702181 42 3976547
SGTC_2673 kobusone 100 µM 2.17784451925056 0.0206085412028246 no 143 0.0147088070934988 17 6710676 An epoxy ketone and protein crosslinker.
SGTC_722 3534-0461 190 µM 2.1641295202452 0.0212573404173526 no 144 0.0152272052451157 27 658262
SGTC_904 1141-0088 396 µM 2.16310884082647 0.0213063075955422 no 145 0.0152664046446518 41 1378119
SGTC_709 3807-1509 243 µM 2.16186780505056 0.0213659748546448 no 146 0.0153141836078603 59 1886677 YPL242C IQG1
SGTC_929 2805-0021 398 µM 2.15951339152426 0.0214795600543293 no 147 0.0154051797694577 37 3098024
SGTC_48 0382-0018 55 µM 2.13036564971409 0.022928534321169 no 148 0.0165707187117179 21 762596
SGTC_1667 st014849 34.6 µM 2.12280779517054 0.0233174133955112 no 149 0.0168849806839361 36 5348460
SGTC_1707 st032323 6.317 µM 2.12034947976966 0.0234450930335402 no 150 0.0169882919042407 74 3132057 YMR211W DML1
SGTC_452 diindolylmethane 8 µM 2.10341500844419 0.0243407101079765 no 151 0.0177147538128982 27 3071 Inhibits expression of several cancer promoting factors.
SGTC_681 1642-0006 26.6 µM 2.09507083848051 0.0247924690032424 no 152 0.0180823478945108 34 4446530
SGTC_36 0335-0881 14.2 µM 2.09462585400276 0.0248167569850656 no 153 0.0181021325388421 92 23828853
SGTC_2987 9018338 71.43 µM 2.09181647491242 0.024970558645672 no 154 0.0182274680123966 53 5055682
SGTC_421 streptovitacin 30 mM 2.08832772651611 0.0251626645827248 no 155 0.0183841410086954 34 91467 include heat shock
SGTC_654 1124-0271 80.9 µM 2.08678441345507 0.0252480405474838 no 156 0.0184538133455546 55 5403748
SGTC_1680 diphenhydramine 100 µM 2.08252966259884 0.0254846708889387 no 157 0.0186470581870145 64 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1300 1094-0077 113 µM 2.08186580385953 0.025521758738746 no 158 0.0186773645355365 41 5532636
SGTC_1649 st011737 51.3 µM 2.07234091815551 0.0260588813846591 no 159 0.019116829505493 32 1761035
SGTC_2991 9074669 71.4286 µM 2.07232689963444 0.0260596788245449 no 160 0.0191174827243434 89 17333109
SGTC_1166 k206-0078 225 µM 2.06287845240614 0.0266018136132128 no 161 0.0195620889162177 45 5404595
SGTC_1612 st002233 45.4 µM 2.05016252262705 0.0273462738917415 no 162 0.0201742869195465 36 1035021
SGTC_2011 4012611 177 µM 2.04373453216496 0.0277291668807221 no 163 0.0204898899101669 51 2049887
SGTC_2251 lansoprazole 556 µM 2.04038793577954 0.0279302738955644 no 164 0.0206558512731966 34 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1004 4084-0029 199 µM 2.03080630891869 0.0285127912545165 no 165 0.0211373234017446 35 716894 YLR208W SEC13
SGTC_2153 5569715 200 µM 2.02260562806902 0.0290193476636603 no 166 0.0215569117440933 52 2054701
SGTC_3074 9116018 49.47 µM 2.01537598830071 0.0294721042903386 no 167 0.021932634197135 49 17027303
SGTC_1980 st071811 45.7 µM 2.01112257308875 0.0297412039610192 no 168 0.02215625571127 47 4974850
SGTC_1768 st044301 37.178 µM 2.00481522947488 0.0301439993868025 no 169 0.0224914019013103 64 3931349
SGTC_578 3460-0051 92 µM 2.00470284498352 0.0301512172171702 no 170 0.0224974121012776 63 2876744
SGTC_2345 9052315 157.45 µM 1.99659247498296 0.0306758962149647 no 171 0.022934735487318 50 6469265
SGTC_1963 st076565 50.3 µM 1.99548651695975 0.0307480255722111 no 172 0.0229949216224162 62 4914280
SGTC_1609 st001574 46.4 µM 1.99498482046241 0.0307807919285849 no 173 0.0230222677289345 50 3960012
SGTC_2052 5265182 7.135 µM 1.99137255197564 0.0310175675241907 no 174 0.0232199722679672 56 1239884
SGTC_413 propylparaben 100 µM 1.98436027940883 0.0314815082335154 no 175 0.023607845353734 51 7175 A pharmaceutical preservative.
SGTC_854 0422-0053 192 µM 1.98356434319295 0.0315345290190593 no 176 0.0236522137477641 52 3596728
SGTC_1053 3366-3204 134 µM 1.98336367338589 0.03154790815489 no 177 0.0236634108782845 61 3632071 YPR165W RHO1
SGTC_1063 disulfiram 1.84 µM 1.98182917376574 0.0316503721031946 no 178 0.0237491815469896 61 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1265 0819-1001 68.8 µM 1.97470761982241 0.0321295094627704 no 179 0.0241506688583603 60 3106768
SGTC_2008 4012253 172 µM 1.97182586485775 0.0323250879831252 no 180 0.0243147443111762 55 603940
SGTC_1638 st008370 60.6 µM 1.97121684365732 0.0323665464463416 no 181 0.0243495390560232 70 24207134
SGTC_2813 7971799 71.43 µM 1.96862947698832 0.0325431680848182 no 182 0.0244978275335198 65 2234054
SGTC_1065 prochlorperazine maleate 2.48 µM 1.9654163145686 0.0327636143719629 no 183 0.0246830363772596 56 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1964 st076914 61 µM 1.9629385032112 0.0329344497611677 no 184 0.0248266600770687 66 24208661
SGTC_2091 4-phenylthiadiazole 200 µM 1.95993663279738 0.033142399762777 no 185 0.0250015986173592 49 270010
SGTC_693 4161-2696 114 µM 1.95638450054261 0.0333898643638131 no 186 0.0252099383113604 47 805759
SGTC_1657 st012939 43.4 µM 1.95259912489122 0.0336552507561998 no 187 0.025433557473484 32 24207257
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.94486569809335 0.0342028252123443 no 188 0.0258955722096671 88 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1340 1486-1359 257 µM 1.9363181118795 0.0348165461825941 no 189 0.0264143759301765 54 4309068
SGTC_667 1498-1044 59 µM 1.90268151757265 0.0373200573511384 no 190 0.0285410575277184 56 6739982
SGTC_1386 3228-0095 33.8 µM 1.90122577934088 0.0374316420657771 no 191 0.0286362229138084 52 870181
SGTC_1696 st025591 34.7925 µM 1.88822358771006 0.0384404138077148 no 192 0.0294979702433572 45 2787147
SGTC_2603 homopterocarpin 100 µM 1.88805725780667 0.0384534606212894 no 193 0.0295091320466322 62 101795 A weak amylase inhibitor.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.8851529393991 0.0386818558468037 no 194 0.0297045961956562 70 165521
SGTC_1836 st055642 81 µM 1.88060772310111 0.0390415082750845 no 195 0.030012650192675 72 8571
SGTC_1318 1280-3875 124 µM 1.87758749397618 0.0392819941149098 no 196 0.0302188089408516 60 373245
SGTC_3092 9117248 49.47 µM 1.87498153538871 0.0394904611714006 no 197 0.0303976318990932 40 17141857
SGTC_2474 5321570 43.32 µM 1.874932952821 0.0394943561256742 no 198 0.0304009739809087 56 2841384
SGTC_2714 st079313 56.9 µM 1.8687371577893 0.0399936513914226 no 199 0.0308296958370417 45 2939799
SGTC_1804 st050076 49.1 µM 1.8633188789523 0.0404344828553604 no 200 0.0312087077762757 68 3895976
SGTC_1006 4099-6547 255 µM 1.85353899718969 0.0412401573220623 no 201 0.0319025710019213 62 3146833
SGTC_98 0074-0023 107.663 µM 1.84822142787932 0.0416836554264788 no 202 0.0322851584025708 44 3563821
SGTC_1370 2001-0092 44.6 µM 1.84663754825528 0.0418164989840136 no 203 0.0323998442279899 65 790957
SGTC_751 0833-0568 350 µM 1.84129655469682 0.0422669892790332 no 204 0.0327890561766802 51 6954252
SGTC_3099 9120367 49.47 µM 1.83964693817277 0.042406918473682 no 205 0.0329100442221553 55 24824940
SGTC_1835 st008666 49.2 µM 1.83693919664114 0.0426374155382465 no 206 0.0331094360107441 41 690455
SGTC_403 arphamenine a 50 µM 1.83613316054944 0.0427062248358066 no 207 0.0331689825085845 73 5487158 An arginine aminopeptidase inhibitor.
SGTC_1728 st035614 33.7865 µM 1.8209094153091 0.0440227789825411 no 208 0.0343103138706875 77 15945546
SGTC_190 3970-0790 3.722 µM 1.81841870725693 0.0442412592363235 no 209 0.0345000806277375 53 2832352
SGTC_971 1315-0384 26.7 µM 1.81089925946805 0.0449061575749137 no 210 0.0350782236247992 67 6769120
SGTC_304 1310-0298 97 µM 1.80225831073328 0.0456801318143979 no 211 0.0357523871625165 71 1550234
SGTC_1233 0325-0408 14.2 µM 1.79867147920964 0.0460045395610709 no 212 0.0360353315187638 54 12874
SGTC_1444 4112-3581 28 µM 1.79675129806102 0.0461789677583685 no 213 0.0361875555765793 63 2877249
SGTC_2972 9093619 59.92 µM 1.78543085155249 0.047218133434434 no 214 0.0370957290703772 52 25236256
SGTC_2658 polymyxin b sulfate 77.05 µM 1.78088753833622 0.0476404244310206 no 215 0.0374654124070588 73 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_136 0097-0015 404.482 µM 1.77571902539425 0.0481244984485627 no 216 0.0378896199767104 73 4861337
SGTC_2265 7929201 200 µM 1.77417967304422 0.0482694297661125 no 217 0.0380167176838209 73 1265108
SGTC_1454 4239-0054 42.6 µM 1.76847138012983 0.0488099208603118 no 218 0.0384910663349239 75 1340767
SGTC_1711 st032263 62.8 µM 1.76761707075761 0.0488912258518357 no 219 0.0385624711089781 61 3958979
SGTC_3187 9109394 49.47 µM 1.75777289284171 0.0498359291210632 no 220 0.0393930796883451 84 17098090
SGTC_1636 st007707 68.9 µM 1.74931318413798 0.0506593533579891 no 221 0.0401184491156232 64 403051
SGTC_2923 7992654 58.14 µM 1.74391675045528 0.0511902505146324 no 222 0.0405868036767437 73 2985126
SGTC_3276 9139060 49.47 µM 1.74343062881633 0.0512382913508152 no 223 0.0406292110140691 90 4870619
SGTC_2380 9035439 200 µM 1.74263091460887 0.0513174009215085 no 224 0.0406990531719617 61 6462575
SGTC_767 0929-0023 86 µM 1.73971298575167 0.0516068734895022 no 225 0.0409547139949029 89 1204563
SGTC_496 calpeptin 138 µM 1.7375563237425 0.0518216579353464 no 226 0.0411445107076991 57 73364 A calpain inhibitor.
SGTC_764 1951-2361 146 µM 1.73628016303516 0.0519490864438193 no 227 0.0412571544948669 97 5438930
SGTC_1956 st077085 54 µM 1.72623418797498 0.0529609215231757 no 228 0.0421526448966624 80 24208685
SGTC_1777 st045864 34.765 µM 1.72527224574197 0.0530586231670414 no 229 0.0422392106137265 85 4691462
SGTC_1226 3909-7979 35.4 µM 1.72427052854836 0.0531605164905756 no 230 0.0423295085296167 92 6615510
SGTC_2803 7707263 71.43 µM 1.72223578196194 0.0533679657401982 no 231 0.0425134077055573 64 2199229
SGTC_1767 st044992 70.3 µM 1.7200499377275 0.0535915341614212 no 232 0.0427116822970547 61 9600693
SGTC_793 0488-0545 106 µM 1.71599027763435 0.0540087247575823 no 233 0.0430819109478707 78 292548
SGTC_1198 1612-1005 86.7 µM 1.71482364958277 0.054129087535675 no 234 0.0431887820987213 82 6998509
SGTC_1114 scopoletin 1.73284 µM 1.69887401282224 0.0557960134926224 no 235 0.0446714622099159 62 5280460 A coumarin with genotoxic properties.
SGTC_2318 6029776 164 µM 1.69204424066629 0.056522077676935 no 236 0.0453187693380831 82 818325
SGTC_295 k015-0027 31 µM 1.68580286332966 0.0571920820672471 no 237 0.0459168880536915 65 3887424
SGTC_1193 1488-0126 41.5 µM 1.68413291032646 0.0573724054295997 no 238 0.0460779926875922 60 1384710
SGTC_826 1683-5028 118 µM 1.68284638767156 0.0575116303832989 no 239 0.0462024161958299 66 722377
SGTC_2635 hydroquinidine 100 µM 1.67638340729413 0.0582150664381374 no 240 0.0468315584456517 49 442912 An experimental heart treatment.
SGTC_1440 4100-1550 40 µM 1.67503260532163 0.0583629393274097 no 241 0.0469639172820475 71 742806
SGTC_2260 7964312 200 µM 1.66970546986685 0.0589489807673624 no 242 0.0474888255013933 80 231951
SGTC_1514 1189-1591 158 µM 1.66731959080307 0.0592129452573286 no 243 0.0477254365797486 81 767698 YMR146C TIF34
SGTC_2178 5812956 200 µM 1.66319181417429 0.0596718146691305 no 244 0.0481370228484775 69 5403383
SGTC_522 1273-0010 11.6 µM 1.66286348284102 0.0597084333301766 no 245 0.0481698827874632 92 5705015
SGTC_2596 sinensetin 100 µM 1.65985662917718 0.0600446059842845 no 246 0.0484716491333005 77 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2082 5219693 150 µM 1.65539811468262 0.06054580334306 no 247 0.0489218840928592 69 2834649
SGTC_2737 bleomycin 30.5 nM 1.65340770716931 0.0607706061537547 no 248 0.0491239576822566 85 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2740 felodipine 17.08 µM 1.65310873508902 0.0608044293043191 no 249 0.0491543679495846 38 3333 L-type calcium channel blocker
SGTC_2729 fluphenazine 10.66 µM 1.64700881878466 0.0614977408618798 no 250 0.0497781166000024 88 3372 An atypical antipsychotic.
SGTC_2697 mebhydrolin 72.4 µM 1.6469430450499 0.0615052501576706 no 251 0.0497848765615237 81 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3109 9122853 49.47 µM 1.64553479635617 0.0616661998209016 no 252 0.04992978650446 81 1234709
SGTC_328 k915-0120 63.5 µM 1.64262348699729 0.0619999777655888 no 253 0.0502304290992883 54 6624543
SGTC_1296 1068-0102 11.9 µM 1.64145397560162 0.0621344570163362 no 254 0.0503516067063025 52 767053
SGTC_2313 7726885 200 µM 1.63810688861582 0.0625205880789647 no 255 0.0506996991239409 89 726423
SGTC_2055 5235184 200 µM 1.63742087724821 0.0625999591449498 no 256 0.0507712794621407 71 2836034
SGTC_1573 oleylamine 1.06 µM 1.63576724871242 0.0627916057361872 no 257 0.0509441544741624 84 5356789 An amine of the fatty acid oleic acid.
SGTC_1826 st055655 41.6 µM 1.63550816451544 0.0628216735741507 no 258 0.0509712822790248 88 676168
SGTC_2948 9070189 9.45 µM 1.6350967583569 0.0628694420823515 no 259 0.0510143828116626 68 6473636 YDL196W YDL196W
SGTC_3268 9137683 49.47 µM 1.63181240972233 0.0632518042991125 no 260 0.0513595051313486 84 1953228
SGTC_2029 5175081 200 µM 1.63032523080002 0.0634255353737975 no 261 0.0515163888891835 77 1380876
SGTC_92 0063-0024 660.874 µM 1.62819228561448 0.0636753524232793 no 262 0.0517420600162924 65 3594437
SGTC_752 1896-0090 130 µM 1.62759782791524 0.063745113357347 no 263 0.0518050950015154 86 772567
SGTC_197 4544-0043 41.561 µM 1.62619151434625 0.0639103840768592 no 264 0.0519544603841487 103 896523
SGTC_1613 st002381 52.1 µM 1.62590566646712 0.0639440177865055 no 265 0.0519848622578482 80 551167
SGTC_405 ebelactone b 50 µM 1.61740168399468 0.0649509308184907 no 266 0.0528958012393752 52 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_572 0960-0087 17.7 µM 1.61397205902304 0.0653604810848053 no 267 0.0532667435001464 119 6796365
SGTC_2300 7976697 71.57 µM 1.6106965839215 0.0657534909147736 no 268 0.053622935320336 59 2236109
SGTC_1670 st016595 4.04 µM 1.60827652131602 0.0660450384148827 no 269 0.0538873152146045 84 597879
SGTC_2368 9071271 200 µM 1.59869113695503 0.0672096480373876 no 270 0.0549446239624216 64 27209959
SGTC_2448 5185112 27.17 µM 1.59682658318745 0.0674380221737562 no 271 0.0551521842917162 83 5718189
SGTC_1977 st070720 65.3 µM 1.59643277569439 0.0674863330976465 no 272 0.0551961016876266 60 682188
SGTC_2423 st077119 87.2 µM 1.59584754932716 0.0675581760185798 no 273 0.0552614171308342 84 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1949 st076024 69.1 µM 1.59378151707545 0.0678122766629464 no 274 0.0554924893511922 80 2921930
SGTC_2180 6301957 200 µM 1.59340434585676 0.0678587444067732 no 275 0.0555347557115245 81 845462
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.59176215481426 0.0680613501000482 no 276 0.0557190783266721 85 803109
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.58081424825315 0.0694240054819203 no 277 0.0569602578629464 81 6708784 An antioxidant flavonoid
SGTC_2655 perillic acid 100 µM 1.58041445823746 0.0694741610159979 no 278 0.057005991316641 71 5702197 An apoptosis inducer.
SGTC_470 aa-861 153 µM 1.57925665339886 0.0696195704971005 no 279 0.0571385999878574 99 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_942 3253-1115 227 µM 1.57707466493383 0.0698942446431759 no 280 0.0573891729686473 101 46497897
SGTC_3293 9120939 62.045 µM 1.56928153632191 0.0708820746238624 no 281 0.0582911762952772 87 934087
SGTC_1931 st074438 57.1 µM 1.55623063755578 0.0725603339088035 no 282 0.0598266292324753 126 2787313
SGTC_2058 5236698 133 µM 1.55450583209643 0.0727843907827458 no 283 0.0600319033030095 79 766665
SGTC_2179 6298986 200 µM 1.55359202076559 0.0729033118101984 no 284 0.0601408819116434 85 738374
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.55324833459447 0.0729480767038867 no 285 0.0601819090310609 83 23665772 A membrane-active detergent.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.5531736223997 0.0729578107006356 no 286 0.0601908306071634 100 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3113 9123498 49.47 µM 1.55117105732127 0.0732190886857285 no 287 0.0604303480855797 96 8897275
SGTC_2236 dapsone 200 µM 1.55021948694336 0.0733434922801443 no 288 0.0605444220735896 57 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2323 6148992 148.28 µM 1.54952218464495 0.0734347567266507 no 289 0.0606281213825874 83 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1109 tnp00067 928.257 nM 1.54870159070808 0.0735422690678876 no 290 0.0607267356624317 71 676295
SGTC_118 0083-0097 135.343 µM 1.54671293629896 0.0738033172612535 no 291 0.0609662411484374 134 5207356
SGTC_834 0312-0008 75.7 µM 1.54563627024644 0.0739449450773385 no 292 0.0610962182299939 89 6385573 YIL048W NEO1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.54385328505399 0.0741799407730242 no 293 0.0613119396276237 90 688664
SGTC_178 4092-0806 87.505 µM 1.54166361922231 0.0744693164738457 no 294 0.0615776785002012 106 2169044
SGTC_1285 0929-0069 65.5 µM 1.53649868688872 0.0751553020792383 no 295 0.0622080597979854 74 1206237
SGTC_2887 9044784 58.44 µM 1.53360487798086 0.0755417465230243 no 296 0.0625634437739024 119 6465546
SGTC_217 ketoconazole 989 nM 1.53124077036832 0.0758585759477958 no 297 0.0628549489678486 97 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1218 1348-1416 30.7 µM 1.53052812557861 0.0759542803384858 no 298 0.0629430285724942 90 6787668
SGTC_1724 st037281 8.293 µM 1.52962376590025 0.0760758633449252 no 299 0.0630549416490942 101 574124 YDL195W SEC31
SGTC_237 nikkomycin 200 µM 1.52870187836675 0.076199955252491 no 300 0.0631691832236059 96 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3046 9092212 49.47 µM 1.52830198705911 0.0762538310411656 no 301 0.0632187883992438 77 25236637
SGTC_816 0325-0417 81.3 µM 1.52709808262527 0.076416203381581 no 302 0.0633683118284956 97 68101
SGTC_1038 k292-0204 154 µM 1.52554297234831 0.0766263325543208 no 303 0.0635618618840831 87 4454212
SGTC_1074 carmofur 3.8 µM 1.52302128640567 0.0769680007329907 no 304 0.0638766899899255 114 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_142 0335-0849 62.6745 µM 1.52101016666467 0.0772413203366565 no 305 0.06412864302056 112 3889043 YPR107C YTH1
SGTC_3204 9114183 49.47 µM 1.51615136247378 0.0779046943117859 no 306 0.0647405416420606 98 17027248
SGTC_1923 st058458 19.1 µM 1.51203746440373 0.078469738470607 no 307 0.0652621660090421 108 3534982
SGTC_1958 st076513 41.9 µM 1.50373705971819 0.079619250177231 no 308 0.0663245414645656 96 732122 YGL099W LSG1
SGTC_781 4335-2806 94.4 µM 1.50315158954948 0.0797008096484583 no 309 0.0663999789493977 108 845254
SGTC_2013 4024628 200 µM 1.49755573239422 0.0804835373690063 no 310 0.0671243576728688 115 5230760
SGTC_2809 7964133 12.99 µM 1.49723670841784 0.0805283356156866 no 311 0.0671658384456185 107 1253665
SGTC_1153 4055-0057 267 µM 1.48713589906502 0.0819564783021858 no 312 0.0684894608890498 112 882706
SGTC_603 3794-0023 45.9 µM 1.48544217265009 0.0821978094860975 no 313 0.0687133655682555 102 3802260
SGTC_2187 6125751 200 µM 1.48383042146785 0.0824279570549003 no 314 0.0689269571484108 105 874498
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.4835031343392 0.0824747507310632 no 315 0.068970392157333 116 688803
SGTC_2133 5320837 200 µM 1.47820492649254 0.0832350435828839 no 316 0.0696764678411268 71 2841355
SGTC_1871 st057448 67.3 µM 1.47820488699039 0.083235049271021 no 317 0.0696764731261221 97 691747
SGTC_1942 st076330 65.2 µM 1.47608623977981 0.0835405457522435 no 318 0.069960371187782 100 24208414
SGTC_1726 st035556 14.5795 µM 1.47203945621535 0.0841264086922914 no 319 0.0705051115546765 78 5919439
SGTC_2007 4011539 71.82 µM 1.47121612019004 0.0842459817864322 no 320 0.0706163395088601 76 45595301
SGTC_1848 st056003 16.4 µM 1.4705476712814 0.0843431544081421 no 321 0.0707067422581665 103 146492
SGTC_2904 7225135 42.03 µM 1.46798733676201 0.0847161291421403 no 322 0.0710538313461418 122 4446116
SGTC_2528 xanthyletin 44.79 µM 1.46727412711916 0.0848202453365331 no 323 0.0711507495065284 96 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2896 9052656 71.43 µM 1.464951182206 0.0851600200066125 no 324 0.0714671186116069 149 6469436
SGTC_1733 st037357 54.9 µM 1.46486660356181 0.0851724104502667 no 325 0.0714786579766444 118 1272339 YGL099W LSG1
SGTC_963 1269-2853 151 µM 1.46140660651689 0.0856804453303281 no 326 0.0719519443696521 93 3668223
SGTC_474 dl-dihydrosphingosine 5 µM 1.45998777160422 0.0858894289641562 no 327 0.0721467173647226 101 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3140 9094243 49.47 µM 1.45982178126324 0.0859139029879964 no 328 0.0721695303542492 109 19291112
SGTC_2825 7998094 58.44 µM 1.45771671765115 0.0862247316573342 no 329 0.0724593210079964 111 2987815
SGTC_666 0272-0154 136 µM 1.45768167756044 0.086229912701128 no 330 0.0724641522851138 122 6870312
SGTC_227 fluconazole 33.516 µM 1.45219650353073 0.087043827285621 no 331 0.0732234873143986 162 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2942 9052777 62.25 µM 1.44659061272501 0.0878815692088681 no 332 0.0740058084521839 125 6469503
SGTC_946 3434-1334 87.4 µM 1.44407106035922 0.088260042778982 no 333 0.0743594938012422 116 4047976
SGTC_3097 9117246 49.47 µM 1.44220807709047 0.0885406703492139 no 334 0.0746218413392483 94 16423892
SGTC_2280 7785178 200 µM 1.44064620298514 0.088776452602696 no 335 0.07484233020653 93 2954328
SGTC_2961 9083290 32.55 µM 1.43430447291191 0.089738611675323 no 336 0.0757426972195939 99 17741490
SGTC_3318 9139014 38.6185 µM 1.43218484811928 0.0900619207868933 no 337 0.0760454634234056 113 16643984
SGTC_1252 0493-0875 34.8 µM 1.43180540636017 0.0901198887457166 no 338 0.0760997598039739 90 3960963
SGTC_733 4069-0007 56.1 µM 1.43167122253634 0.0901403948682661 no 339 0.0761189679574008 115 5717425 YNL287W SEC21
SGTC_1419 3993-2473 62.6 µM 1.43070792760262 0.0902877084554077 no 340 0.0762569701174934 104 704026
SGTC_2555 cholic acid 100 µM 1.41903370459217 0.0920872459900545 no 341 0.0779445950003513 75 6708657 Influences liver metabolism.
SGTC_1675 st018485 24.5 µM 1.41889093375577 0.0921094167575912 no 342 0.0779654079472097 121 3323024
SGTC_493 zm226600 134 µM 1.41595586869865 0.0925660767155071 no 343 0.0783942129076194 113 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1969 st069479 40.1 µM 1.4151834884728 0.0926865274610889 no 344 0.0785073521941244 96 3895485
SGTC_2864 9034755 47.6 µM 1.41499207948008 0.0927163951256094 no 345 0.0785354091676608 97 4930451
SGTC_3307 9126885 69.2785 µM 1.41083407767465 0.0933669720933015 no 346 0.0791467718696565 95 24824909
SGTC_290 2043-6722 48.1 µM 1.40703110792819 0.093964946486742 no 347 0.0797090823129628 100 773758 YLR208W SEC13
SGTC_1093 fluphenazine 7.97 µM 1.40648991286752 0.0940502725489349 no 348 0.0797893489199746 119 6602611 An atypical antipsychotic.
SGTC_574 1315-0397 40 µM 1.40149223744584 0.0948409206344471 no 349 0.0805334636095421 132 6794277
SGTC_548 1436-0017 110 µM 1.40138045639753 0.0948586605758731 no 350 0.0805501666636287 106 9677137
SGTC_1178 0988-0033 191 µM 1.40061265915929 0.0949805780600999 no 351 0.0806649666653144 103 5392207
SGTC_1659 st012954 42.1 µM 1.39051871106368 0.0965941298252742 no 352 0.0821857107503674 93 24207262
SGTC_999 SEC7.066 22.7 µM 1.38831519546978 0.0969490314121646 no 353 0.082520543543138 132 740511 YDR170C SEC7
SGTC_2210 7115885 190.385 µM 1.38736889095102 0.0971017381457607 no 354 0.08266465300341 106 2927039
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.3840921198643 0.0976318801073612 no 355 0.0831651247533184 86 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1027 k015-0025 8.67 µM 1.38255313685609 0.0978816001618405 no 356 0.083400963407588 119 3598955
SGTC_1789 tunicamycin 25 nM 1.37999423349812 0.0982978513918301 no 357 0.0837942101616318 131 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_901 1112-0062 60.1 µM 1.37945960472205 0.0983849817816874 no 358 0.0838765463662647 106 1908457
SGTC_907 3448-6986 75.5 µM 1.37507210665473 0.0991021656481855 no 359 0.084554545489524 131 590582
SGTC_1335 1486-0900 202 µM 1.37423391891863 0.0992396103842011 no 360 0.0846845368699984 102 X1335
SGTC_937 3122-0005 46.7 µM 1.37341382576225 0.0993742228513598 no 361 0.084811867032104 111 759535
SGTC_1497 4476-2978 41.3 µM 1.37106873023378 0.0997598901293652 no 362 0.0851767658207535 113 1528379
SGTC_2779 methotrexate 400 µM 1.36012292753991 0.101574470570934 no 363 0.0868955133886647 127 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_582 0987-0078 156 µM 1.35944793373688 0.101687151862316 no 364 0.0870023453114524 113 1625765
SGTC_2157 5649910 96.377 µM 1.35939974824118 0.101695199272814 no 365 0.0870099754265788 106 2858091
SGTC_2757 clomiphene 4.22 µM 1.35838258069403 0.101865183605461 no 366 0.087171159340222 152 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1744 st037937 38.9 µM 1.35798603659585 0.101931508216413 no 367 0.0872340574692262 109 1016152
SGTC_1234 0326-0494 15.5 µM 1.35762969887502 0.101991134850998 no 368 0.08729060713564 136 1547813
SGTC_2239 6685329 187.64 µM 1.35720532904512 0.102062178529566 no 369 0.0873579889816702 90 805680
SGTC_1407 3909-7909 12.3 µM 1.35550574491631 0.102347066482321 no 370 0.0876282397410737 110 4411780
SGTC_2892 9047358 58.44 µM 1.34641922769326 0.10387998233045 no 371 0.0890836767081826 108 6466771
SGTC_2038 4100038 30.985 µM 1.345620050227 0.104015597849344 no 372 0.0892125410304794 141 3596803
SGTC_2694 st077685 81.9 µM 1.33787051995177 0.10533730812159 no 373 0.0904693243003431 101 2838096
SGTC_165 k038-0023 64.381 µM 1.33665066400451 0.105546460838202 no 374 0.0906683465498391 129 46368543
SGTC_1800 st050079 29.0735 µM 1.32911602069867 0.10684498593446 no 375 0.0919048477693421 143 3645560
SGTC_90 0870-0863 4.608 µM 1.32803279139273 0.107032613972 no 376 0.0920836371528758 133 1738164
SGTC_1187 1391-0724 117 µM 1.32709925378418 0.107194504213522 no 377 0.0922379260765081 117 6997986
SGTC_1957 st077035 62.4 µM 1.32594596083389 0.107394747227324 no 378 0.092428798823447 117 705593
SGTC_2121 5257820 149.641 µM 1.32539433482035 0.107490619769696 no 379 0.0925201975102655 105 791256
SGTC_1136 pergolide 1.05886 µM 1.32058171671571 0.108329669693334 no 380 0.0933204362055141 143 47811 A dopamine receptor agonist.
SGTC_13 0199-0087 65 µM 1.31963680847298 0.108494960594105 no 381 0.0934781536469963 133 4589825
SGTC_196 k015-0023 18.111 µM 1.31477128404172 0.10934894979746 no 382 0.0942933905321605 87 5211998
SGTC_1574 spiramycin 23.7 µM 1.30995684392074 0.110198715088687 no 383 0.0951052177126028 134 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_488 nitrendipine 139 µM 1.30939460634619 0.110298259983875 no 384 0.0952003587804418 108 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_920 mycophenolic acid 780.421 nM 1.30886666329829 0.110391791678627 no 385 0.0952897603626071 111 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2647 atorvastatin 60.16 µM 1.30820775893377 0.110508604565505 no 386 0.0954014255577322 102 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3223 9129970 49.47 µM 1.30718641146471 0.110689847727117 no 387 0.0955747046850365 137 17248386
SGTC_1235 benzylparaben 21.5 µM 1.30610294058283 0.110882347742627 no 388 0.0957587765576149 119 7180
SGTC_424 splitomicin 100 mM 1.30290756800116 0.111451465173442 no 389 0.0963031599478525 124 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2931 9014674 55.67 µM 1.30131266907377 0.111736308270983 no 390 0.0965757262254073 124 2996810
SGTC_650 1328-0195 38 µM 1.2990167315452 0.112147268088007 no 391 0.096969093628365 124 2780821
SGTC_1183 1254-0324 198 µM 1.29801010159242 0.112327789425384 no 392 0.0971419318979842 98 5799357
SGTC_2299 7976368 114.88 µM 1.29665528496842 0.112571079559265 no 393 0.0973749105557553 110 2979718
SGTC_2181 6316240 54.2555 µM 1.29547491961915 0.112783349341496 no 394 0.0975782239126989 105 12779990
SGTC_1238 0333-0287 48.8 µM 1.29502537618393 0.112864267620089 no 395 0.097655737828503 124 7226
SGTC_835 0312-0010 67.2 µM 1.28833678600845 0.114073119135319 no 396 0.0988143765742594 136 1626196
SGTC_2198 6589944 200 µM 1.28725063257555 0.114270290561099 no 397 0.0990034722208041 110 5290268
SGTC_2069 5228469 200 µM 1.28654449780648 0.114398606606583 no 398 0.0991265498045997 133 2835210
SGTC_2830 7992007 71.43 µM 1.28595635298047 0.114505560258219 no 399 0.0992291474125482 134 1952075
SGTC_2403 6032726 181.2 µM 1.27409421586148 0.116677889799622 no 400 0.101315014041995 114 2881040
SGTC_2482 5981709 142.65 µM 1.27409077635298 0.116678523890546 no 401 0.101315623450902 150 877755
SGTC_1961 st076550 68.7 µM 1.27255443220181 0.116962001104425 no 402 0.101588098554227 138 1579337
SGTC_2630 antimycin a 100 µM 1.2706656668098 0.11731117345376 no 403 0.101923807369282 150 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_170 4197-0004 226 µM 1.26976429142248 0.117478068933982 no 404 0.10208430196106 139 218692
SGTC_385 1494-0393 12.4 µM 1.26683732606592 0.11802117456118 no 405 0.102606731261286 135 3090647
SGTC_2614 arthonioic acid 13.39 µM 1.26472010379503 0.118415135757336 no 406 0.102985840336337 110 6710684
SGTC_2636 apigenin dimethyl ether 100 µM 1.26436593730159 0.118481127778483 no 407 0.103049356477653 134 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_392 N-ethylmaleimide 8.33 µM 1.26046097980492 0.119210464079193 no 408 0.103751557803392 143 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_957 1187-1561 14.1 µM 1.2594370774971 0.119402223544388 no 409 0.103936252119593 128 1538454
SGTC_117 lucigenin 22.078 µM 1.25867309125749 0.119545446873736 no 410 0.104074217309501 132 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2387 9077560 195.08 µM 1.25847708571613 0.119582211258529 no 411 0.1041096345518 120 5303272
SGTC_3285 9112818 20.8695 µM 1.25813850007176 0.119645737906738 no 412 0.104170835904397 164 17017947 YPR165W RHO1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.25217197673578 0.120769105346837 no 413 0.10525360245429 120 5379071
SGTC_1016 4226-1401 38 µM 1.25107140751946 0.120977127129596 no 414 0.105454213083179 141 2901613
SGTC_1676 st018489 23.4 µM 1.25089348171101 0.12101078106283 no 415 0.105486671168876 119 3696235
SGTC_1899 st063254 59.6 µM 1.24860269002661 0.12144466327662 no 416 0.105905213988291 128 3093813
SGTC_96 0929-0093 37.281 µM 1.24723244418169 0.121704713731676 no 417 0.106156139928037 153 6991579
SGTC_795 0685-0265 78 µM 1.24641489016244 0.121860058486696 no 418 0.106306058730843 158 302754
SGTC_2470 5664817 21.68 µM 1.24540460199289 0.122052217318656 no 419 0.106491531268874 124 2859561
SGTC_2507 purpurin 79.67 µM 1.24483886306674 0.122159914889231 no 420 0.106595493754642 132 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1491 4138-0063 26.5 µM 1.24433537439829 0.122255818213884 no 421 0.106688078475905 124 23883227
SGTC_2926 9010726 65.15 µM 1.2416143488687 0.122775027328945 no 422 0.107189442535357 125 2994293
SGTC_2425 5628681 7.85 µM 1.23528906957496 0.123987947935708 no 423 0.108361470122404 132 5714958
SGTC_89 0302-0250 142.109 µM 1.23500205517755 0.124043183325107 no 424 0.108414869632312 145 4203518 YLR208W SEC13
SGTC_2885 9057732 51.95 µM 1.23441057094409 0.124157067669466 no 425 0.108524975976328 156 6471414
SGTC_62 0180-0423 3.232 µM 1.2252881468658 0.125922766986726 no 426 0.110233336389723 168 30102 YGL099W LSG1
SGTC_2240 6690706 185.951 µM 1.22460800525771 0.126055110389579 no 427 0.110361475132597 115 805876
SGTC_334 1502-1024 68.5 µM 1.22358047902233 0.126255232495752 no 428 0.110555263681624 118 3296216
SGTC_2419 paclitaxel 166.5 µM 1.22275700939533 0.126415772070069 no 429 0.110710743705342 149 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1703 st026983 48.3 µM 1.22159818215669 0.126641932126846 no 430 0.110929808209971 128 1104023
SGTC_714 4296-0578 26.1 µM 1.22133493558042 0.126693347338326 no 431 0.110979615548654 142 1589775
SGTC_690 glyoxal 20.3 µM 1.21932045702974 0.127087280394541 no 432 0.111361293564775 154 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2212 7123476 200 µM 1.21807366100452 0.12733151905261 no 433 0.111597990980209 108 1085715
SGTC_14 0354-0009 295 µM 1.21501797727345 0.12793148623848 no 434 0.112179617452957 144 1713507
SGTC_3207 9114163 49.47 µM 1.21469268156637 0.127995471803519 no 435 0.112241662418308 165 849233
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.21370897406415 0.128189102029016 no 436 0.112429438136031 147 1377
SGTC_1347 1493-0251 600 nM 1.21246639257377 0.128433978933871 no 437 0.112666949857323 142 3986378
SGTC_2695 st077686 51.995 µM 1.2110105750591 0.128721291357532 no 438 0.112945675884839 122 2876092
SGTC_2558 carylophyllene oxide 100 µM 1.20996001210318 0.128928901704114 no 439 0.113147118713657 136 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_58 0957-0393 9 µM 1.20834536064851 0.1292484387488 no 440 0.113457223667923 188 6997992
SGTC_2776 terbinafine 19.92 µM 1.2071736038606 0.129480671072311 no 441 0.11368264684873 130 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3005 9076496 71.4286 µM 1.20092118510401 0.130724734091724 no 442 0.114890887778984 133 21368410
SGTC_1981 st071826 47 µM 1.19859401128559 0.131189882299558 no 443 0.115342923983724 140 11838600
SGTC_684 1140-0066 328 µM 1.19755154888198 0.131398616710894 no 444 0.115545823970704 138 6813534
SGTC_551 k048-0028 34.9 µM 1.19679314119006 0.1315506182755 no 445 0.115693596149971 162 6836383
SGTC_1729 st035615 45.989 µM 1.19665551372441 0.131578214848789 no 446 0.11572042659952 148 17385451
SGTC_997 3996-0078 137 µM 1.1960598939807 0.131697692479418 no 447 0.115836593510531 146 735687
SGTC_2678 equilin 100 µM 1.195205085837 0.131869292480056 no 448 0.116003455991316 121 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_17 0960-0276 49.807 µM 1.19408732310566 0.132093912392375 no 449 0.116221905764545 162 6821114
SGTC_1383 3049-0032 20.7 µM 1.19281642359621 0.132349626244514 no 450 0.116470638262169 160 712864
SGTC_2884 9058502 51.95 µM 1.1917414824533 0.132566178068839 no 451 0.116681313570345 132 6471554
SGTC_829 1635-0120 117 µM 1.18985363796348 0.132947083551639 no 452 0.117051961668433 172 285054
SGTC_1801 st050089 28.441 µM 1.18468547105655 0.133993703496275 no 453 0.118070914523523 150 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1364 1653-0028 37.6 µM 1.18322369817069 0.134290755589857 no 454 0.118360251656052 135 5718652
SGTC_1352 1496-0991 99 µM 1.1823819346314 0.13446201841966 no 455 0.118527094008613 156 3000039
SGTC_2087 5276107 200 µM 1.18048951443855 0.134847592198743 no 456 0.118902789200387 141 144405
SGTC_2315 7733312 200 µM 1.18014855576578 0.134917141860882 no 457 0.118970567781489 146 726316
SGTC_2194 5927483 104.545 µM 1.17585605099836 0.135794843544062 no 458 0.119826201815584 113 760979
SGTC_3057 9095946 49.47 µM 1.17099599439227 0.13679330497714 no 459 0.120800193617379 160 24540043
SGTC_1865 st057639 52.2 µM 1.16445985373768 0.138144000463722 no 460 0.122118851862921 163 688818
SGTC_1669 st015249 58.4 µM 1.16144245369161 0.138770605114053 no 461 0.122731006383479 131 722793
SGTC_1771 st048882 4.1505 µM 1.16071661609222 0.138921623661537 no 462 0.122878581148486 158 4580403
SGTC_3082 9117008 49.47 µM 1.15898064444089 0.139283265510906 no 463 0.123232037376391 145 41448529
SGTC_3132 9126706 49.47 µM 1.15728632352662 0.139636847767417 no 464 0.123577699654391 167 850858
SGTC_1484 3473-2379 286 µM 1.15553901507315 0.140002126579675 no 465 0.123934882647145 132 671917
SGTC_2838 9002687 71.43 µM 1.15482900443286 0.140150741282703 no 466 0.124080228541772 172 6457060
SGTC_3078 9116413 49.47 µM 1.15274431459393 0.140587713794471 no 467 0.124507673301835 151 17177322
SGTC_2890 9046729 58.44 µM 1.15257098819831 0.140624086391341 no 468 0.124543258441776 156 903329
SGTC_137 0438-0332 85.389 µM 1.14855598194162 0.141468424413639 no 469 0.125369558275438 181 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1096 rimcazole 32.2 µM 1.14283740532936 0.142676935851762 no 470 0.126553052613951 135 18528119 A dopamine reuptake inhibitor.
SGTC_3088 9117578 49.47 µM 1.14101437142303 0.143063662093762 no 471 0.126931971255264 159 678341
SGTC_2478 5763493 32.33 µM 1.1407540406679 0.143118944654537 no 472 0.126986145523478 158 1365576 YLR208W SEC13
SGTC_195 4234-0266 16.654 µM 1.14042736401323 0.143188336518966 no 473 0.127054148994685 170 2303354
SGTC_2037 5169046 200 µM 1.13846617938404 0.143605404321182 no 474 0.127462936720749 157 5718022
SGTC_3355 9151058 44.0485 µM 1.13768238095888 0.143772316898364 no 475 0.127626566562984 146 17015728
SGTC_3306 9127676 59.7925 µM 1.13744907916178 0.143822024590218 no 476 0.127675300052054 142 41905287
SGTC_2059 5238311 157 µM 1.13641267337159 0.144042983181466 no 477 0.127891947118309 158 703021
SGTC_2250 alverine citrate 130 µM 1.13568227483148 0.144198839395967 no 478 0.128044780737294 167 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_489 paxilline 115 µM 1.13322830304844 0.144723313005825 no 479 0.128559195702144 144 105008 A toxic potassium channel blocker.
SGTC_2938 9059746 27.26 µM 1.13320381021503 0.144728554188958 no 480 0.128564337242487 160 6471769
SGTC_3332 9141069 11.198 µM 1.13306186050035 0.144758932303874 no 481 0.128594138164369 149 17332883
SGTC_1259 0671-0132 43 µM 1.13269110045011 0.144838297497063 no 482 0.128671998137487 153 X1259
SGTC_3233 9132340 49.47 µM 1.13142235612617 0.145110107574405 no 483 0.128938683150834 179 17682950
SGTC_649 1123-0311 367 µM 1.12525017888583 0.146437302225363 no 484 0.13024151753294 168 693629 YIL048W NEO1
SGTC_2706 st078239 82.5 µM 1.12424923513972 0.146653299255886 no 485 0.130453653857035 165 15434492
SGTC_3319 9138450 16.7555 µM 1.12288238635859 0.14694860131908 no 486 0.130743724541064 140 2029690
SGTC_1896 st058441 89 µM 1.12273265068389 0.146980975316096 no 487 0.130775528305974 154 688759
SGTC_2732 terfenadine 20 µM 1.12034020155842 0.147498889849247 no 488 0.131284408396193 173 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1046 2001-0062 216 µM 1.11839976069818 0.147919851112684 no 489 0.131698148249619 168 739778
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.11789778342356 0.14802888139868 no 490 0.131805325925564 165 91467 include heat shock
SGTC_3279 9140807 49.47 µM 1.11789281887999 0.148029959974215 no 491 0.131806386210712 157 45595718
SGTC_2120 5538279 151.968 µM 1.11568095564033 0.148511023172157 no 492 0.132279362649794 130 2058197
SGTC_563 tetrahydrosecaminediol 614 µM 1.1141868482899 0.148836570926982 no 493 0.132599518178207 144 334274 A psychoactive constituent of the cannabis plant.
SGTC_1718 roemerine 11.9335 µM 1.11238846376254 0.149229048968878 no 494 0.132985581287867 171 235224 An aporphine alkaloid with mutagenic activity.
SGTC_516 3992-2719 87.3 µM 1.11171285105898 0.149376672584188 no 495 0.133130816288875 121 5350887 YDR037W KRS1
SGTC_1107 amlodipine 47 µM 1.11062066345551 0.149615525317866 no 496 0.133365832298254 136 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2929 9013348 24.6 µM 1.10844238060654 0.150092659038646 no 497 0.133835405206033 139 2995952
SGTC_2051 5263410 176 µM 1.10551463524233 0.150735552226417 no 498 0.134468328188655 153 227584
SGTC_360 0957-0399 1.01 µM 1.10476379157507 0.150900722287458 no 499 0.134630976878117 154 6752301 YPR165W RHO1
SGTC_3317 9138495 8.753 µM 1.10347361883918 0.151184814824258 no 500 0.134910770933648 173 17020139
SGTC_797 k781-0471 270 µM 1.10304208320264 0.151279917158962 no 501 0.13500444511639 170 23738129
SGTC_1362 1611-0397 101 µM 1.10273240144693 0.151348189709548 no 502 0.135071695754611 162 27816
SGTC_596 1155-0152 116 µM 1.10143916469719 0.151633518576689 no 503 0.135352783929078 174 280313
SGTC_1255 0566-0045 221 µM 1.09600690928 0.152835948751692 no 504 0.136537875415729 167 2788469
SGTC_1674 st016616 23.6 µM 1.09528231528669 0.152996814352671 no 505 0.136696486374182 152 625830
SGTC_1513 0337-0559 19 µM 1.09501820702892 0.153055476378897 no 506 0.136754330014091 147 775073
SGTC_638 3970-0837 4.09 µM 1.0916505302976 0.153804790065761 no 507 0.137493368447297 136 4118451 YLR208W SEC13
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.08961731332288 0.154258357804261 no 508 0.137940876645718 162 97141
SGTC_1764 st044502 93.5 µM 1.08899347153034 0.154397700885471 no 509 0.138078382315283 152 8407
SGTC_1091 telmisartan 47.6 µM 1.08865531690649 0.1544732668356 no 510 0.138152956578073 169 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_231 b-estradiol 524 µM 1.08780900125968 0.154662496475226 no 511 0.138339717489679 155 450 A steroid.
SGTC_2979 9012552 45.46 µM 1.08675488438345 0.154898402989338 no 512 0.138572575547692 172 17100905
SGTC_1770 st043884 66.3 µM 1.08664826353403 0.154922277474132 no 513 0.138596143324501 200 670149
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.08576377140931 0.155120426192371 no 514 0.138791759280004 177 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3289 9119912 71.43 µM 1.08512285296063 0.155264112721668 no 515 0.138933623457242 152 17014829
SGTC_2675 theaflavin digallate 100 µM 1.08037240171145 0.156331846976568 no 516 0.139988190218716 165 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2035 5154463 94.595 µM 1.08019010585726 0.156372916798539 no 517 0.140028766699721 207 2769623
SGTC_1738 st035555 74 µM 1.0798005872404 0.156460696090564 no 518 0.140115494818553 173 5331140
SGTC_7 0192-1582 4.227 µM 1.07956638296721 0.156513490405085 no 519 0.140167659045376 199 252616
SGTC_2449 5812982 45.77 µM 1.07904805619597 0.156630373298007 no 520 0.140283152667347 147 776185
SGTC_855 0428-0020 25 µM 1.07881500708018 0.156682944686795 no 521 0.140335101750614 157 6812414
SGTC_903 1134-0042 114 µM 1.07825880007939 0.156808461198202 no 522 0.140459138894875 163 701009
SGTC_47 0149-0135 24.25 µM 1.07123544810021 0.158399078055966 no 523 0.142031788257322 173 5239155
SGTC_3053 9095903 49.47 µM 1.07097129398914 0.158459108293829 no 524 0.142091168582076 200 17174018
SGTC_3146 9095609 49.47 µM 1.06977016729623 0.158732258036438 no 525 0.142361386849712 155 17173999
SGTC_2677 mitomycin C 100 µM 1.06787260451402 0.159164413856964 no 526 0.142788990837977 176 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_382 3229-0966 23.2 µM 1.06638143058115 0.159504557905639 no 527 0.143125626224995 166 5722370
SGTC_1559 coumarin 343 70.1 µM 1.06541454784674 0.159725362674955 no 528 0.143344188160285 151 108770 A hepatotoxic, DNA x-linker.
SGTC_2339 9000433 200 µM 1.06437046719895 0.159964021431344 no 529 0.143580453492114 158 2988954
SGTC_1062 mesoridazine 14.2 µM 1.06385345716495 0.160082287262344 no 530 0.143697545101739 152 4078 A neuroleptic.
SGTC_2111 5486399 200 µM 1.06256627219022 0.160376978578413 no 531 0.143989344563168 169 689674
SGTC_2166 5933061 31.504 µM 1.06091210556934 0.160756207755422 no 532 0.144364923639084 159 2877375
SGTC_482 fipronil 114 µM 1.06060490780524 0.160826699390391 no 533 0.144434745620867 147 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2560 caryophyllene 100 µM 1.05604247159932 0.161876001395234 no 534 0.145474405677784 181 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_785 1270-0111 65.3 µM 1.0537570877807 0.162403283426925 no 535 0.145997072380445 174 6741994
SGTC_3267 9137951 49.47 µM 1.05231985664482 0.162735452211034 no 536 0.146326412226205 184 16643986
SGTC_3273 9137859 49.47 µM 1.05051188361096 0.163153932937627 no 537 0.146741415098384 207 2377234
SGTC_492 tmb-8 126 µM 1.0495516161057 0.163376484442244 no 538 0.146962156089838 160 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1080 nisoldipine 24.4 µM 1.04903525775384 0.163496237094482 no 539 0.147080945719928 183 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3300 9124615 50.48 µM 1.04639281685505 0.164109958015336 no 540 0.147689853906327 168 24824903
SGTC_3154 9100113 49.47 µM 1.0454765680998 0.164323110101582 no 541 0.147901382392177 171 25237525
SGTC_2989 9073649 71.4286 µM 1.04319548363097 0.1648545509207 no 542 0.148428882395725 184 21367202
SGTC_1366 1683-0113 21.9 µM 1.04113850576411 0.165334733432562 no 543 0.148905635420599 167 708623
SGTC_2132 5317594 122.667 µM 1.04050461273732 0.165482892151565 no 544 0.149052761061513 193 794577
SGTC_1180 1193-0155 285 µM 1.03996042596614 0.165610152473137 no 545 0.14917914344969 171 2921347
SGTC_978 1416-0512 87.4 µM 1.03986190210515 0.165633199449281 no 546 0.149202032362 166 6814003
SGTC_2889 9059656 51.95 µM 1.03876125098936 0.165890807824383 no 547 0.149457893380705 178 3949838
SGTC_2264 7948757 110.76 µM 1.0381442474173 0.166035331272396 no 548 0.149601452111481 153 2971411
SGTC_1863 st057641 20.1 µM 1.03771433928682 0.166136078612877 no 549 0.149701533565459 192 3921635
SGTC_1774 st048371 48.465 µM 1.03674035739868 0.166364473631117 no 550 0.149928439124591 212 4242727
SGTC_3200 9114385 49.47 µM 1.0363797188172 0.166449093405787 no 551 0.150012514137269 159 17018030 YLR208W SEC13
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.03564919261068 0.166620588277493 no 552 0.150182916690412 158 4174840
SGTC_321 4534-3890 65.3 µM 1.03386428463295 0.167040084335658 no 553 0.150599806883799 184 699746
SGTC_1809 st050081 57.6 µM 1.03261772401144 0.16733345944985 no 554 0.150891415200261 191 5036894
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.03071684101629 0.16778146665813 no 555 0.151336812448696 176 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_545 4218-0007 221 µM 1.02748938090211 0.16854389363881 no 556 0.152095041600057 186 2840508
SGTC_87 0100-0052 35.5 µM 1.02743727774278 0.168556220275163 no 557 0.152107302883458 194 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.02638573383101 0.168805119839905 no 558 0.152354899927995 186 66535 A nucleotide analog.
SGTC_3210 9128157 49.47 µM 1.02559104031373 0.168993379730814 no 559 0.152542196238407 161 17590849
SGTC_2105 5350118 200 µM 1.02523897616816 0.169076825485938 no 560 0.152625220833327 182 2133313
SGTC_1929 genistein trimethyl ether 50.5 µM 1.02432436508377 0.169293728974941 no 561 0.152841046646715 176 136420
SGTC_2875 9039966 71.43 µM 1.0240044811252 0.169369632811704 no 562 0.152916579173725 164 6463691
SGTC_1763 st044482 94.5 µM 1.02319541206306 0.169561710668662 no 563 0.153107730867957 192 88505
SGTC_333 3486-0131 40.1 µM 1.02290736251285 0.169630129084854 no 564 0.153175824037731 178 6744690
SGTC_3124 9127567 49.47 µM 1.02006142487923 0.17030705658406 no 565 0.153849665027518 151 17592030
SGTC_2951 9072950 58.06 µM 1.01915241143037 0.170523636354391 no 566 0.154065307587848 198 16488155
SGTC_2702 st077768 96.8 µM 1.01857616131851 0.170661023877314 no 567 0.154202113201351 168 6484119
SGTC_211 3455-0679 143.504 µM 1.0183094619192 0.170724633388464 no 568 0.154265456604346 151 748649
SGTC_1448 4255-0083 152 µM 1.01701846332554 0.171032759286614 no 569 0.154572323104584 203 5399660
SGTC_155 k072-0202 43.6 µM 1.01531863260912 0.171439004351927 no 570 0.154976982679666 191 5857737
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.01529162506176 0.171445463898916 no 571 0.154983417703683 150 521171
SGTC_1248 0469-0687 58.6 µM 1.01339539767448 0.171899384103619 no 572 0.155435668415048 180 4017482
SGTC_3044 9093193 49.47 µM 1.01230206423404 0.172161455473395 no 573 0.155696824094595 180 25236277
SGTC_589 1227-0070 34.1 µM 1.01139480084516 0.172379119442591 no 574 0.155913754295293 171 2841384
SGTC_652 0437-0092 114 µM 1.01074604195198 0.172534872508583 no 575 0.15606899718352 171 3091274
SGTC_613 3914-0030 117 µM 1.00833568841755 0.173114332389631 no 576 0.156646667779291 146 1145395
SGTC_838 0109-0203 71.4 µM 1.00652323173191 0.17355087067722 no 577 0.157081971022562 174 759422
SGTC_1567 st069303 68.4 µM 1.00643999034411 0.173570936548435 no 578 0.157101982450832 191 5581319
SGTC_3195 9113082 49.47 µM 1.00498090124737 0.173922899061082 no 579 0.157453023206967 174 17018038
SGTC_711 k292-0785 179 µM 1.00401716171979 0.174155621695861 no 580 0.157685170806326 195 4146315
SGTC_1689 st020265 53.493 µM 1.0016989423019 0.174716232674326 no 581 0.158244508844331 179 5758320 YPR016C TIF6
SGTC_254 nsc-64875 3.808 µM 1.00140400968847 0.174787637776528 no 582 0.158315763181402 155 56993
SGTC_3192 9110362 49.47 µM 1.00071301015682 0.174955005782032 no 583 0.158482787854177 180 16649480
SGTC_1403 3909-7815 62.9 µM 0.998765514047885 0.175427258629201 no 584 0.158954147767968 179 6615483
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.995853266866968 0.176134962352093 no 585 0.159660722337252 176 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_159 3970-0959 50 µM 0.994048538961222 0.176574434050677 no 586 0.160099618533671 201 6615653
SGTC_1510 1123-0200 71.5 µM 0.99321554822772 0.17677751043393 no 587 0.160302461408813 206 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2786 7743617 45.45 µM 0.99143167748462 0.177212900062029 no 588 0.160737419309139 166 583674
SGTC_1591 genipin 88.4 µM 0.991428798105381 0.177213603379622 no 589 0.160738122005245 181 442424 A DNA cross-linking agent.
SGTC_1151 3909-8316 15.3 µM 0.990647925022531 0.177404404618298 no 590 0.160928763672816 194 800431
SGTC_1847 st056231 15 µM 0.990256245392138 0.177500157801877 no 591 0.161024443552849 186 5393180
SGTC_1436 4092-1007 8.32 µM 0.989492201392037 0.177687036067188 no 592 0.1612111917848 157 2881121
SGTC_1203 3992-3522 103 µM 0.989258035307591 0.177744335822734 no 593 0.161268455119195 199 5322312
SGTC_199 4063-0024 41.6 µM 0.988808900089215 0.177854270513944 no 594 0.161378324461593 165 306215
SGTC_2865 9030313 51.95 µM 0.988659595485263 0.177890825252564 no 595 0.161414858789214 167 42562754
SGTC_1329 1447-1697 50.6 µM 0.988504453221104 0.177928814264416 no 596 0.161452827286101 179 2840515
SGTC_2992 9074591 71.4286 µM 0.986817962032906 0.178342108076334 no 597 0.161865943756124 186 17741321
SGTC_74 000s-0487 160.283 µM 0.986264918339086 0.178477769310607 no 598 0.162001565059891 184 677548
SGTC_3011 9081274 71.4286 µM 0.985951316967844 0.178554724382626 no 599 0.162078501491539 181 6625322
SGTC_856 0433-0016 11.3 µM 0.984551050798168 0.178898592550804 no 600 0.162422321790954 177 3911780
SGTC_3258 9138477 49.47 µM 0.980765045806909 0.179830419935036 no 601 0.163354309546178 195 4970355
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.98040538206093 0.179919100173792 no 602 0.163443027061935 183 5355888
SGTC_2860 9025725 38.96 µM 0.978755191306563 0.180326330288617 no 603 0.163850477321209 186 40546248
SGTC_86 0417-1630 471.922 µM 0.976579666240271 0.180864084240364 no 604 0.164388644892045 212 3634867
SGTC_1286 0929-0070 131 µM 0.97583954919743 0.181047257882679 no 605 0.164571991282249 193 1420408
SGTC_3175 9106517 49.47 µM 0.97348886142799 0.181629806653846 no 606 0.165155196735304 191 41468073
SGTC_950 1165-0508 94.1 µM 0.973048141384696 0.181739156575097 no 607 0.165264688083021 192 6148369
SGTC_2709 st078560 56 µM 0.972372640082461 0.181906839528965 no 608 0.165432599036297 212 17250903
SGTC_947 3447-0010 211 µM 0.971935793544573 0.182015331560132 no 609 0.165541245756264 205 748350
SGTC_1098 clofazimine 15.1 µM 0.971213163615704 0.182194887473389 no 610 0.165721070048164 206 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_819 1013-0258 27.7 µM 0.970940217319379 0.182262736767062 no 611 0.165789024765125 202 5753198
SGTC_2400 5203494 178.7 µM 0.970766231501298 0.18230599459461 no 612 0.165832350953549 207 6777674
SGTC_2213 7173844 200 µM 0.969943052585466 0.18251074727903 no 613 0.166037439325968 195 892728
SGTC_523 1934-0222 13.7 µM 0.967111287545173 0.18321620021477 no 614 0.166744201690892 203 1361595
SGTC_806 3966-4455 5.86 µM 0.966964879886765 0.18325271965461 no 615 0.166780795352699 172 714982
SGTC_425 3825-7017 13.1 µM 0.966577852979908 0.183349280219526 no 616 0.166877555213417 201 3397440
SGTC_2908 7930301 100 µM 0.966557097577536 0.183354459446494 no 617 0.166882745254915 209 2223178
SGTC_3227 9130768 49.47 µM 0.965571329106882 0.183600549535158 no 618 0.167129363837285 184 17720899
SGTC_276 colchicine 750 µM 0.964070183782766 0.183975694948967 no 619 0.167505370009762 199 2833 A microtubule depolymerizer.
SGTC_2330 7979373 200 µM 0.963938904681347 0.184008525080709 no 620 0.167538278631689 181 1863007
SGTC_1825 st052143 62.6 µM 0.961402442523204 0.184643556640148 no 621 0.16817492832495 186 674173
SGTC_507 nimesulide 162 µM 0.960388714873317 0.184897735330748 no 622 0.16842980782003 177 4495 A COX2 inhibitor.
SGTC_2000 st075254 36.4 µM 0.959753837640283 0.185057033011385 no 623 0.168589560150939 174 17234175
SGTC_438 sphingosine 6.67 µM 0.958863422248833 0.185280591619839 no 624 0.168813776857956 165 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2191 5911152 200 µM 0.957431622326495 0.185640428335002 no 625 0.169174721911783 176 2875902
SGTC_3259 9138485 49.47 µM 0.956804900237352 0.18579807105707 no 626 0.169332869228949 168 17646153
SGTC_2232 chlorophetanol 41.5365 µM 0.95655765996571 0.185860283542746 no 627 0.169395284036906 186 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1076 itraconazole 331 nM 0.955946643972794 0.186014087460931 no 628 0.169549595880014 187 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1019 4262-0212 3.4 µM 0.955156834518802 0.186213013850904 no 629 0.169749195531984 208 4677213
SGTC_3039 9090270 49.47 µM 0.951042149074781 0.187251495562302 no 630 0.170791489967869 171 17173750
SGTC_2922 7999257 32.47 µM 0.950375958891144 0.187419967658675 no 631 0.170960627604795 211 2988377
SGTC_1118 chelidonine 707.474 nM 0.948623037771407 0.18786370934006 no 632 0.171406184830818 186 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2712 st079126 47.7 µM 0.946439504613376 0.188417364486214 no 633 0.17196223206827 197 3152970
SGTC_1305 1181-0477 144 µM 0.946043042699178 0.188517998939525 no 634 0.172063316403793 212 6252086
SGTC_2704 st078022 71.1 µM 0.943112257778725 0.189262951666735 no 635 0.172811743288475 183 54697681
SGTC_3054 9094397 49.47 µM 0.937263723354709 0.190754951164634 no 636 0.174311459168195 200 2598354
SGTC_3290 9121031 71.43 µM 0.937261100418902 0.190755621907869 no 637 0.174312133606739 201 17014854
SGTC_198 3454-2873 16.191 µM 0.936564152684127 0.190933898283209 no 638 0.174491399340547 210 710957
SGTC_922 1866-0035 480 µM 0.935326368931456 0.191250770139167 no 639 0.174810064997719 207 3156169
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.934488758388226 0.191465380677221 no 640 0.175025916057917 219 5282309
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.932419076095638 0.191996302057723 no 641 0.175559995036858 190 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_88 0180-0332 8.668 µM 0.932183780104694 0.19205671790833 no 642 0.175620778195076 201 3101745
SGTC_177 1327-0068 8.361 µM 0.930411674329879 0.192512106861731 no 643 0.176078988171468 208 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1271 0832-2808 169 µM 0.928228892989059 0.193073936048318 no 644 0.176644424972659 232 3663794
SGTC_330 1488-0319 80.1 µM 0.925242403545065 0.193844252732488 no 645 0.177419915533661 213 6846614
SGTC_206 4546-0025 72.014 µM 0.923747992672223 0.194230414091661 no 646 0.177808769206617 211 6620745 YIL048W NEO1
SGTC_2984 9022109 38.96 µM 0.923633734886026 0.194259957997843 no 647 0.177838521798156 231 6459207
SGTC_2607 solasodine 47.35 µM 0.922880469462464 0.194454800105618 no 648 0.178034749804102 219 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_689 0833-0039 98 µM 0.922533799702126 0.194544510801479 no 649 0.178125104217662 224 5374726
SGTC_2512 diallyl trisulfide 49.23 µM 0.922430081495279 0.194571355742524 no 650 0.178152142471538 243 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2388 9080168 200 µM 0.922375543116045 0.194585472582867 no 651 0.17816636109551 226 15943073
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.921869677170526 0.194716441795178 no 652 0.178298278778654 189 641818 YHR062C RPP1
SGTC_3325 9138760 55.175 µM 0.920901437064665 0.194967269660642 no 653 0.178550944129247 185 43844959
SGTC_3239 9133757 49.47 µM 0.920588192915067 0.195048459302668 no 654 0.178632734447362 210 17036923
SGTC_3220 9131269 49.47 µM 0.920233477898313 0.195140422575231 no 655 0.178725381589864 207 17722206
SGTC_1145 3546-0597 10.2 µM 0.917300894741774 0.195901732048406 no 656 0.179492494328164 210 875334
SGTC_300 r073-0011 5.04 µM 0.91685839875472 0.196016761928112 no 657 0.179608423025255 195 2735780
SGTC_1447 4239-0816 81.9 µM 0.916854896666816 0.196017672483374 no 658 0.179609340718358 207 1341554
SGTC_2832 7992762 51.95 µM 0.916169713958895 0.196195871771288 no 659 0.17978894384962 203 2985177
SGTC_1292 0kpi-0043 232 µM 0.915298906308194 0.196422489276208 no 660 0.18001736656186 211 3333905
SGTC_2964 9083345 53.42 µM 0.914284505123914 0.196686675262762 no 661 0.180283685146442 220 17741579
SGTC_1783 st039459 87.517 µM 0.912827128442081 0.197066604263847 no 662 0.180666734040683 217 729761
SGTC_2540 epiandrosterone 100 µM 0.911213566512573 0.197487767478897 no 663 0.181091428624506 229 441302 A steroid.
SGTC_3182 9108849 49.47 µM 0.910908754949489 0.197567388816689 no 664 0.181171726166208 208 17133045
SGTC_37 0566-0070 1.56 µM 0.910600358700776 0.197647966274347 no 665 0.181252990726816 205 1626686
SGTC_1094 duloxetine 25.4 µM 0.910543898302468 0.197662720340529 no 666 0.181267870907077 201 60834 A selective serotonin reuptake inhibitor.
SGTC_637 1181-0519 7.26 µM 0.91048854140672 0.197677186688902 no 667 0.181282461001135 214 6252091 YGR060W ERG25
SGTC_361 000s-0510 1.45 µM 0.909307832073109 0.197985892335753 no 668 0.181593828775804 208 660
SGTC_2253 7938677 135.83 µM 0.908693484246699 0.198146633457404 no 669 0.181755972256421 184 2301972
SGTC_2171 5739187 198.077 µM 0.906932940889027 0.198607707293994 no 670 0.182221130099729 197 2262761
SGTC_1554 st069299 38.7 µM 0.906391068900629 0.198749749858033 no 671 0.182364449149004 190 24207999
SGTC_2681 menadione 3.18 µM 0.906259306449006 0.198784298408466 no 672 0.182399309478297 230 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_985 1493-0307 8.71 µM 0.905690594835186 0.198933458008129 no 673 0.182549820999573 209 3278274
SGTC_3350 9150499 3.57 µM 0.904589105218524 0.199222544445378 no 674 0.182841554618881 224 4910996 YPR165W RHO1
SGTC_2496 diffractaic acid 79.83 µM 0.903415948066477 0.199530718145013 no 675 0.183152589475908 201 94870 An apoptosis inducer which activates caspases.
SGTC_2679 rapamycin 1 nM 0.903387042295347 0.199538314949325 no 676 0.183160257320855 208 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2755 lomerizine 42.69 µM 0.902364551900661 0.199807150406143 no 677 0.183431622543926 193 3949 A calcium channel blocker.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.90212375585429 0.199870492720421 no 678 0.183495565380411 232 442882
SGTC_2375 9072683 200 µM 0.900950152118773 0.20017938646836 no 679 0.183807411988486 219 16798029
SGTC_481 bay k-8644 50 µM 0.898063736014689 0.200940313818652 no 680 0.184575785484963 213 2303 A calcium channel antagonist.
SGTC_1130 3454-2858 15.9 µM 0.897186228232991 0.201171989101235 no 681 0.184809776327382 233 715628 YIL048W NEO1
SGTC_867 0518-0118 155 µM 0.896787711938163 0.201277256278013 no 682 0.184916103092382 224 6848158
SGTC_297 0986-0032 24 µM 0.894465970163368 0.201891195454366 no 683 0.185536314655784 222 2847425
SGTC_1311 1190-0148 100 µM 0.893820493104168 0.202062078194199 no 684 0.185708971328873 219 1961333
SGTC_1025 k007-0731 70 µM 0.893747119268654 0.202081508563395 no 685 0.185728604177786 194 6256118
SGTC_606 k015-0008 38.6 µM 0.891778781187919 0.202603167919893 no 686 0.186255758555893 229 1970475
SGTC_3299 9121982 43.1275 µM 0.891407638048629 0.202701620350901 no 687 0.186355260785128 197 17594604 YPL160W CDC60
SGTC_2274 7947094 46.08 µM 0.891107208018807 0.202781335784108 no 688 0.186435829180044 212 2971028
SGTC_3249 9135183 49.47 µM 0.889598049714494 0.203182055755115 no 689 0.186840876907322 203 4902779
SGTC_1824 st053723 68.6 µM 0.889037271995004 0.203331076895287 no 690 0.186991524474734 205 675225
SGTC_2446 5162541 200 µM 0.886359129367184 0.204043665863027 no 691 0.187712017791529 218 1549321
SGTC_2485 5633444 17.78 µM 0.885512103655198 0.204269348229011 no 692 0.187940247257557 219 5724239
SGTC_1694 st024011 44.9 µM 0.885167507124732 0.20436120538631 no 693 0.188033147145162 227 2787533
SGTC_2040 5100729 123 µM 0.884867112037321 0.204441300071927 no 694 0.188114153873175 208 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2409 alverine citrate 63.97 µM 0.884822874677392 0.204453096707955 no 695 0.188126085061211 168 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1983 st071813 46.9 µM 0.882708678654005 0.205017354875367 no 696 0.188696845936972 204 11838595
SGTC_1879 gemcitabine 100 µM 0.881523856337244 0.205333976656709 no 697 0.189017173785442 219 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1511 0906-3109 28.5 µM 0.880029972835139 0.205733603009191 no 698 0.189421536322608 206 2882180
SGTC_3003 9075612 71.4286 µM 0.879595512447634 0.205849911382265 no 699 0.1895392353801 235 6501993
SGTC_2728 chlorpromazine 9.18 µM 0.877745205049244 0.206345689522585 no 700 0.190041003299163 259 2726 A thorazine and dopamine antagonist.
SGTC_1761 st044296 37 µM 0.87716263317049 0.206501932314502 no 701 0.190199154469246 224 1826700
SGTC_2420 aureobasidin a 50 nM 0.876890478985999 0.206574946683109 no 702 0.190273064047938 188 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.875881089928373 0.206845882203928 no 703 0.190547340341427 213 364106
SGTC_342 k048-0088 23.3 µM 0.874988917923047 0.207085529896983 no 704 0.190789967801556 234 6820570
SGTC_45 0kpi-0036 14.9 µM 0.874877468291885 0.207115478090504 no 705 0.190820290003173 214 2795021
SGTC_2661 dactinomycin 12.96 µM 0.874305318509063 0.207269263682843 no 706 0.190976001859747 213 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1051 3253-3903 78 µM 0.873512362727501 0.2074825103416 no 707 0.191191935381117 238 5509239
SGTC_2428 5615643 7.78 µM 0.87343238896232 0.207504024586203 no 708 0.191213721720002 228 2253075
SGTC_94 0334-0113 514.748 µM 0.870666697277586 0.208248851576581 no 709 0.191968083620902 226 6795178
SGTC_2835 9006588 71.43 µM 0.868429464573767 0.208852512028663 no 710 0.192579635300534 187 2345538
SGTC_176 1486-1328 72.834 µM 0.867076317902805 0.209218124133101 no 711 0.192950097692855 207 22310231
SGTC_344 k064-0035 6.43 µM 0.862919709753251 0.210343568415162 no 712 0.194090806576157 210 5088750
SGTC_651 3253-0966 34.4 µM 0.861641981868211 0.21069023931079 no 713 0.194442280671328 223 781462
SGTC_2949 9072542 2.23 µM 0.860923071347231 0.210885440119451 no 714 0.194640206937175 217 16457352
SGTC_462 ag-879 158 µM 0.858683773645956 0.211494140371882 no 715 0.195257502548016 243 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_741 4582-0002 126 µM 0.857551606934511 0.211802284336653 no 716 0.195570053338974 223 2912688
SGTC_260 nsc-65238 3.989 µM 0.856474106814622 0.212095793423707 no 717 0.195867794603277 203 3246252
SGTC_2061 5245884 80.95 µM 0.85639008764679 0.212118690084373 no 718 0.195891022835835 238 573863
SGTC_1572 epiandrosterone 68.9 µM 0.853367559814061 0.212943341349212 no 719 0.196727752681754 197 441302 A steroid.
SGTC_3253 9135987 49.47 µM 0.853168600452209 0.212997689967756 no 720 0.196782906658457 214 4182430
SGTC_1464 k208-0027 110 µM 0.851612082893671 0.213423154433339 no 721 0.19721471552963 228 X1464
SGTC_3302 9125395 16.351 µM 0.851284876965041 0.213512657126644 no 722 0.197305561817356 209 17599668
SGTC_1213 1315-0166 115 µM 0.849708043531939 0.213944284871279 no 723 0.197743712678292 199 768401
SGTC_2234 tolnaftate 200 µM 0.849544601256868 0.213989053078906 no 724 0.197789161590793 220 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2486 5283202 22.39 µM 0.849505628081126 0.21399972896318 no 725 0.197799999917427 214 1377751
SGTC_700 3453-2283 142 µM 0.84913414831138 0.214101503616724 no 726 0.19790332536954 228 565664
SGTC_2349 9023730 187.07 µM 0.848235288264669 0.214347881633311 no 727 0.198153474166231 216 4126287
SGTC_969 1313-0238 134 µM 0.847725276696778 0.214487749369042 no 728 0.198295492987308 247 5212874
SGTC_1773 st048542 73.5835 µM 0.847219115074914 0.214626613729795 no 729 0.198436500466301 245 3237138
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.843224209200446 0.215724439905438 no 730 0.199551530639725 225 688669
SGTC_2684 capsaicin 100 µM 0.842207382539028 0.216004389351725 no 731 0.199835941088919 224 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1717 st033143 58.0435 µM 0.841977564735248 0.216067691197081 no 732 0.199900255802787 210 674616
SGTC_3292 9120825 59.784 µM 0.84190789299782 0.216086883954242 no 733 0.199919755958174 229 24824900
SGTC_2611 pyromycin 23.93 µM 0.841717187239141 0.216139423496227 no 734 0.199973137712043 212 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3252 9135871 49.47 µM 0.841254538520448 0.216266914213528 no 735 0.200102676491901 229 17682838
SGTC_1416 3966-0321 25.3 µM 0.839996267737737 0.216613872254485 no 736 0.200455239578716 228 582530 YLR208W SEC13
SGTC_786 4544-0069 423 µM 0.838332438193188 0.217073153881389 no 737 0.200922011247422 234 748821 YLR208W SEC13
SGTC_609 0986-0026 86.3 µM 0.838287280472048 0.217085627005841 no 738 0.2009346889029 229 2848610
SGTC_1030 k029-0042 36.7 µM 0.837171754788141 0.217393880524943 no 739 0.201248015822541 217 6080581
SGTC_244 nsc-207895 1.295 µM 0.836435721216927 0.21759740719571 no 740 0.20145491196556 180 42640
SGTC_3072 9116419 49.47 µM 0.835329416327471 0.217903527380951 no 741 0.201766129591623 227 17170162
SGTC_678 1218-2179 85.9 µM 0.832318242449042 0.218737991267378 no 742 0.202614668158786 242 6820081 YOR116C RPO31
SGTC_2417 cerulenin 830 nM 0.832089974071082 0.218801324463844 no 743 0.202679080268874 214 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2357 9067248 200 µM 0.831348730399161 0.219007055707971 no 744 0.202888326632803 219 9150235
SGTC_1298 1079-1278 263 µM 0.828988934654879 0.219662754425145 no 745 0.203555334335865 221 2840950
SGTC_1850 st056238 17 µM 0.828511768551984 0.219795477869303 no 746 0.203690366438242 244 5393177
SGTC_1460 k062-0059 9.15 µM 0.827424869569509 0.220097969909872 no 747 0.203998144711907 219 1373085
SGTC_1516 st013856 110 µM 0.827187480570627 0.220164068786187 no 748 0.204065403242102 219 5281404 A mutagen and neurotoxin.
SGTC_2231 micatex 6.853 µM 0.826633658700132 0.220318319862983 no 749 0.204222366855911 239 20737 An antifungal of unknown mechanism.
SGTC_371 0195-0006 7.36 µM 0.825274909812572 0.220697022454709 no 750 0.20460776649604 223 3928593
SGTC_91 0417-1751 58.384 µM 0.824964353246285 0.220783631293743 no 751 0.204695914417165 243 6795624
SGTC_706 4262-0057 46.9 µM 0.824099533674042 0.221024917010664 no 752 0.204941502553946 231 883298
SGTC_1164 k060-0068 93.7 µM 0.823743681457132 0.221124244021549 no 753 0.205042606947341 243 5963676
SGTC_1275 0867-0008 21.1 µM 0.821581119249011 0.221728416694128 no 754 0.205657669329143 211 3422836
SGTC_3179 9107801 49.47 µM 0.820933413680238 0.221909554861939 no 755 0.205842098581921 208 4818259
SGTC_2921 7974240 10.71 µM 0.820588149728999 0.222006146339439 no 756 0.205940449957897 228 2979074 YDR527W RBA50
SGTC_1439 4092-1168 46 µM 0.820184685262775 0.222119050475216 no 757 0.206055415557247 241 2886240
SGTC_3051 9093778 49.47 µM 0.820159122694483 0.222126204921967 no 758 0.206062700791511 262 17217378
SGTC_120 rhodamine 6G 52.259 µM 0.818756101510765 0.222519083897797 no 759 0.206462790674644 265 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3294 9122953 26.2835 µM 0.818699504233805 0.222534940778411 no 760 0.206478939781303 249 16459826
SGTC_1666 st014829 29 µM 0.818623579073532 0.222556213771328 no 761 0.206500604958383 229 3858230
SGTC_150 3970-0969 77.2 µM 0.817903034874853 0.222758156222667 no 762 0.206706278630721 266 6615640
SGTC_1357 1503-1303 39.5 µM 0.817775432264768 0.222793929495012 no 763 0.206742714429945 218 292895
SGTC_598 3937-0236 20.2 µM 0.816588069080228 0.223126962569744 no 764 0.207081937785618 252 1379313
SGTC_2617 dihydrotanshinone i 20.83 µM 0.816231695336242 0.223226973986884 no 765 0.207183816083202 239 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_273 hydroxyurea 18.1 mM 0.816208478702018 0.223233490302951 no 766 0.207190454163871 258 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3037 9091026 49.47 µM 0.815759497130841 0.223359529251144 no 767 0.20731885133669 231 25236398 YIL048W NEO1
SGTC_3301 9125354 19.7965 µM 0.815723659449733 0.223369591416967 no 768 0.207329102018181 208 41905162
SGTC_3172 9105863 49.47 µM 0.813471774795166 0.22400237143086 no 769 0.207973811270893 238 2348785
SGTC_1709 st033179 39.1045 µM 0.812984501973019 0.224139429092405 no 770 0.208113471932808 237 573381
SGTC_3196 9111891 49.47 µM 0.810812292664893 0.224750996336183 no 771 0.208736737025957 251 18891510
SGTC_1476 4112-3294 3.34 µM 0.809952735723667 0.224993258415529 no 772 0.208983670414549 223 704369
SGTC_1276 0871-0068 94.2 µM 0.809891412968176 0.225010547599598 no 773 0.209001293779449 241 3414906
SGTC_448 monastrol 171 µM 0.809397371375442 0.225149863912557 no 774 0.209143306857437 257 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3112 9123419 49.47 µM 0.808908203632742 0.225287853966542 no 775 0.20928397490039 259 17015854
SGTC_2778 tioconazole 65.09 nM 0.806910054601414 0.225852011916249 no 776 0.209859152795212 243 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2332 7982454 138.89 µM 0.806214727822697 0.226048517894967 no 777 0.21005952405297 260 2981748
SGTC_124 0136-0217 7.121 µM 0.806202267390504 0.226052040213152 no 778 0.210063115781586 248 3976905
SGTC_1776 st049249 45.9 µM 0.805165278017484 0.226345285340547 no 779 0.210362155152686 242 1822314
SGTC_2956 9076196 2.52 µM 0.803457120705514 0.226828794900614 no 780 0.210855285553762 266 16423868
SGTC_337 1315-0038 354 µM 0.802571081577185 0.227079825714228 no 781 0.21111134426127 230 1626437
SGTC_1236 0330-0013 258 µM 0.802215988232695 0.227180473989367 no 782 0.211214014724141 238 4617066
SGTC_3221 9128209 49.47 µM 0.801332480757237 0.227431005963649 no 783 0.211469595944374 253 16460723
SGTC_2856 9022925 19.48 µM 0.80069763216919 0.227611122979598 no 784 0.211653356839011 235 4944862
SGTC_3167 9103034 49.47 µM 0.799193683939767 0.228038138236484 no 785 0.212089056862455 220 5127859
SGTC_2819 7996655 46.38 µM 0.798276846321709 0.228298676381253 no 786 0.212354925626628 214 6456960
SGTC_2464 5717415 7.67 µM 0.796966617979489 0.228671294764069 no 787 0.212735209471859 240 5285744
SGTC_2249 haloperidol 116.36 µM 0.795596148637052 0.229061410357148 no 788 0.213133402930163 243 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2414 st077232 92.9 µM 0.795201670460373 0.229173771040017 no 789 0.213248100125489 218 729801
SGTC_2154 5570129 200 µM 0.79474910667633 0.229302714525558 no 790 0.213379730426319 266 673366
SGTC_3160 9100216 49.47 µM 0.793547004810581 0.229645412192506 no 791 0.213729597305075 231 17191039
SGTC_2589 lobaric acid 100 µM 0.792837553370028 0.229847798610403 no 792 0.213936236967611 239 73157 A novel microtubule depolymerizer.
SGTC_2163 5671233 125 µM 0.792109945864517 0.230055468123663 no 793 0.214148285653494 243 701023
SGTC_1579 chlormadinone acetate 49.4 µM 0.788826969980835 0.230993780480319 no 794 0.215106572042991 234 45114258 A steroidal progestin.
SGTC_2214 7179297 48.276 µM 0.788505238572317 0.231085849826174 no 795 0.215200617797653 237 769744
SGTC_1681 tripelennamine 100 µM 0.788298850600414 0.231144922312589 no 796 0.215260959915424 218 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_868 0527-0199 213 µM 0.787113271331664 0.231484422687566 no 797 0.215607780567611 231 2849450
SGTC_1486 3970-0793 4.53 µM 0.786543270900807 0.23164774590877 no 798 0.215774639579263 253 2844330
SGTC_2034 5197015 53.07 µM 0.785926550430949 0.231824528210902 no 799 0.215955259451125 250 780676
SGTC_1665 st014639 11.4 µM 0.785233325045103 0.232023330252368 no 800 0.216158389969125 248 981133 YIL048W NEO1
SGTC_1375 2910-0797 186 µM 0.783993126432689 0.23237922906879 no 801 0.216522071766483 254 742508
SGTC_2463 5473429 200 µM 0.783725496227893 0.232456070513117 no 802 0.216600599350395 236 5399405
SGTC_1782 st039423 80.636 µM 0.78070541244318 0.233324169661388 no 803 0.217487888277149 235 2068169
SGTC_558 k064-0027 21.3 µM 0.780368150095235 0.233421224588204 no 804 0.217587104718455 236 5088526
SGTC_833 3852-0053 558 µM 0.779022230778829 0.233808766488765 no 805 0.217983309699954 249 3123681
SGTC_1775 st081588 35.1725 µM 0.778590938493309 0.23393302751385 no 806 0.218110359308992 247 1426443 YGL099W LSG1
SGTC_2805 7950783 58.44 µM 0.777751994955407 0.234174843040725 no 807 0.218357616597094 231 1178958 YDL195W SEC31
SGTC_749 1000-0129 128 µM 0.777532414371766 0.234238157385157 no 808 0.218422359044769 240 708470
SGTC_3115 9123671 49.47 µM 0.777267802208584 0.234314468822862 no 809 0.218500393559102 263 3286988
SGTC_3134 9127454 49.47 µM 0.770728652019091 0.236204658100914 no 810 0.220433892610136 242 24262820
SGTC_2006 4011487 200 µM 0.769930181518877 0.236436035799836 no 811 0.220670654694573 245 45595294
SGTC_536 3852-0578 10.6 µM 0.769595996585324 0.236532911640433 no 812 0.220769790272898 239 2869208
SGTC_15 0266-0086 27.098 µM 0.768738337742683 0.236781635652961 no 813 0.221024330475337 262 1712902 YIL048W NEO1
SGTC_2452 5863136 48.41 µM 0.768077191614146 0.236973468433808 no 814 0.221220663259974 254 2184096
SGTC_1857 st056007 79.3 µM 0.766602114425323 0.237401772572884 no 815 0.221659058972944 232 619834
SGTC_1693 xanthone 101.9 µM 0.76486164352674 0.237907682683516 no 816 0.222176968074019 276 7020 An insecticide.
SGTC_2086 5274770 176.623 µM 0.764588052301115 0.237987262343891 no 817 0.222258442936278 254 689278
SGTC_134 0269-0018 6.916 µM 0.76267063660726 0.238545391605033 no 818 0.222829923275543 249 4378915
SGTC_1182 1222-0449 220 µM 0.761251931809562 0.238958814795326 no 819 0.223253302611449 258 658318
SGTC_1204 4049-0315 18.3 µM 0.759744368205272 0.23939856123795 no 820 0.223703701148359 249 588402
SGTC_2753 fluvastatin 17.09 µM 0.759656469267126 0.239424214412039 no 821 0.223729977696295 259 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1614 st002383 48.6 µM 0.759569406311907 0.239449625085553 no 822 0.223756006064791 232 1947235
SGTC_830 4076-0286 57.8 µM 0.759353962628829 0.239512511995989 no 823 0.223820422575959 253 6866659
SGTC_1842 st055362 61.2 µM 0.758434682448472 0.239780946484079 no 824 0.224095400854278 230 676032
SGTC_2135 5326629 150.42 µM 0.755742188895081 0.240568111872431 no 825 0.224901891987129 245 5020077
SGTC_370 0180-0345 38.7 µM 0.753220809427299 0.241306524925661 no 826 0.225658618283884 234 3989527
SGTC_1325 1431-0015 227 µM 0.752529095357116 0.241509315889782 no 827 0.225866469764268 226 1103340
SGTC_293 4049-0273 38.5 µM 0.752234618321722 0.24159567629203 no 828 0.22595498929888 244 1380311
SGTC_3334 9142812 21.919 µM 0.750461473052903 0.242116035585025 no 829 0.226488409617405 239 45283678
SGTC_122 0236-0016 402.397 µM 0.750298410742265 0.242163919454745 no 830 0.22653749978879 270 6808838
SGTC_2735 sertaconazole 140 nM 0.750279742652676 0.242169401737998 no 831 0.226543120230431 276 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_954 1189-0853 2.85 µM 0.746423375625437 0.243303347573895 no 832 0.227705851431991 255 2828194
SGTC_1073 triclabendazole 3.09 µM 0.745693692788557 0.24351822964771 no 833 0.227926235052726 241 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1288 0973-0013 65.5 µM 0.744548955169743 0.243855546396048 no 834 0.228272217929465 240 4315430
SGTC_900 1112-0045 141 µM 0.74247738781126 0.24446661005602 no 835 0.228899073551669 241 56211 YIL048W NEO1
SGTC_187 1488-2104 32.728 µM 0.742170022189997 0.244557345918835 no 836 0.228992164523916 253 2852859
SGTC_2322 7413319 38.22 µM 0.74058562344164 0.245025355945652 no 837 0.229472363790934 248 1840400
SGTC_456 gingerol 170 µM 0.739146899434184 0.24545075266141 no 838 0.229908900416517 286 442793 A herb.
SGTC_2833 9001315 45.46 µM 0.738782634653983 0.245558520078114 no 839 0.230019499081922 250 2989378
SGTC_1909 st060837 51.5 µM 0.733221037676326 0.247207065640664 no 840 0.231711813073071 258 678937
SGTC_1156 4092-0367 4.88 µM 0.733185311785807 0.247217674458378 no 841 0.231722706326755 272 1357585
SGTC_271 rotenone 740 µM 0.732960574106528 0.247284415985888 no 842 0.231791238090916 266 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1625 st003711 30.1 µM 0.731500011632512 0.247718401525683 no 843 0.232236898711228 258 24207034 YER133W GLC7
SGTC_2193 5925765 200 µM 0.730696583388767 0.247957302182232 no 844 0.232482251461128 253 877370
SGTC_2159 5658611 73.75 µM 0.729924356839453 0.248187040795642 no 845 0.232718211562431 249 793844
SGTC_2866 9034245 58.44 µM 0.729092975118089 0.248434505005582 no 846 0.232972395723444 245 6462273
SGTC_688 0527-0193 473 µM 0.727148919804115 0.249013673993333 no 847 0.233567366788407 293 4007154
SGTC_2622 2-methoxyxanthone 59.94 µM 0.725918532709913 0.249380599296985 no 848 0.233944357262288 249 71034 A hepatoprotective.
SGTC_1730 st033808 45.1 µM 0.725318757443308 0.249559568056208 no 849 0.234128250485411 270 1045166
SGTC_506 n9-isopropylolomoucine 153 µM 0.724537837696026 0.249792691289053 no 850 0.234367803159115 255 6610355
SGTC_1974 st069448 26.9 µM 0.721864761301855 0.2505915430093 no 851 0.235188814202628 247 6323587 YNR016C ACC1
SGTC_1441 4106-0040 13 µM 0.721540021195371 0.250688684048945 no 852 0.235288663246482 253 2904180
SGTC_1449 4112-4002 201 µM 0.720865099394671 0.250890640370287 no 853 0.235496258798337 257 2059539
SGTC_2897 9048598 12.99 µM 0.719664052902311 0.251250241442471 no 854 0.235865932023712 269 6467404
SGTC_2003 4023581 200 µM 0.719164426471469 0.251399913050334 no 855 0.236019807505957 253 16641307
SGTC_3336 9143619 71.43 µM 0.718001809409091 0.251748377133986 no 856 0.236378085577867 254 45595730
SGTC_2472 5377652 49.4 µM 0.717440962632473 0.251916567447146 no 857 0.236551026009472 273 1610903
SGTC_725 1497-0963 19 µM 0.717342197648215 0.251946191861616 no 858 0.236581487986728 256 3549977
SGTC_680 0417-1641 114 µM 0.716648923757545 0.252154190100449 no 859 0.236795374440803 258 2835990
SGTC_511 blebbistatin 171 µM 0.714543719327192 0.252786354897389 no 860 0.237445516041864 260 3476986 A myosin inhibitor.
SGTC_2383 9036125 200 µM 0.71311131114333 0.253216964512863 no 861 0.237888440359815 265 79580
SGTC_2582 agaric acid 100 µM 0.712368048562878 0.253440555534162 no 862 0.238118447859993 261 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2848 9016370 25.97 µM 0.711206498133318 0.253790185126895 no 863 0.238478141204163 251 7894410
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.710718477717803 0.253937156004893 no 864 0.23862935351364 277 16725076
SGTC_1406 3909-7906 11.9 µM 0.709648274456709 0.254259611762267 no 865 0.238961137828035 262 X1406
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.709365784098262 0.254344762833598 no 866 0.239048757520583 270 688788
SGTC_2377 9073351 62.6 µM 0.707928528170003 0.254778226287437 no 867 0.239494821323304 272 7337946 YHR072W ERG7
SGTC_579 4491-1009 110 µM 0.706905156839967 0.255087101429653 no 868 0.23981270954981 299 1271041
SGTC_2985 9022375 71.43 µM 0.705655832952363 0.255464439179434 no 869 0.240201096897147 276 4939335
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.704486248542914 0.255817957069981 no 870 0.240565005451211 266 4330530
SGTC_960 1222-0186 7.7 µM 0.703957631327297 0.255977820342775 no 871 0.240729579688768 261 3126296
SGTC_2189 6047310 154.431 µM 0.702261375825533 0.256491150003185 no 872 0.241258087916777 268 711535
SGTC_2686 alizarin 95.37 µM 0.701029128771655 0.256864395036171 no 873 0.241642418493594 250 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3171 9103192 49.47 µM 0.700775632759816 0.256941213483035 no 874 0.241721523604213 277 13018434
SGTC_2244 6635614 200 µM 0.697712088888542 0.257870522143454 no 875 0.242678633225023 269 836499
SGTC_1142 3253-1408 9.78 µM 0.696464231209492 0.258249551962696 no 876 0.243069075051076 275 256655
SGTC_3309 9129340 25.759 µM 0.696155115786586 0.258343488656636 no 877 0.243165846560623 265 17158987
SGTC_1163 k060-0048 49.9 µM 0.695513086357826 0.258538650727938 no 878 0.243366906496421 263 6809982
SGTC_955 1216-0110 33 µM 0.695206537541596 0.258631861390018 no 879 0.243462937956155 278 3619719
SGTC_2222 6885208 172.143 µM 0.694086881329943 0.258972457047085 no 880 0.243813862553352 258 609514
SGTC_604 1000-0114 314 µM 0.692365496289545 0.259496548749239 no 881 0.244353914120677 279 1572745
SGTC_526 4469-0568 170 µM 0.69086893724759 0.259952634789269 no 882 0.244823954220917 264 2901964
SGTC_76 0433-0009 400.328 µM 0.690473291144819 0.260073279556613 no 883 0.244948300258064 285 2841569
SGTC_2304 7443016 91.4 µM 0.688160938310074 0.260778964598204 no 884 0.245675719609575 287 939854
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.687729523050502 0.260910733096114 no 885 0.245811562397785 271 115019
SGTC_931 2812-0076 566 µM 0.687534579501057 0.260970286538445 no 886 0.245872958882027 287 3450959
SGTC_2906 7926292 26.41 µM 0.687193408737406 0.261074527853839 no 887 0.245980428690762 291 2966319
SGTC_3038 9091290 49.47 µM 0.686983629525991 0.261138634419395 no 888 0.246046522279758 269 25236843
SGTC_2723 salbutamol 83.58 µM 0.685950315682986 0.261454523499416 no 889 0.24637221984313 274 9884233 β2-adrenoceptor agonist
SGTC_1035 k081-0041 55.2 µM 0.683351683268487 0.262249804383691 no 890 0.247192321589072 270 731709
SGTC_3340 9146634 11.102 µM 0.682966786327433 0.262367702844426 no 891 0.247313915124599 255 4907387
SGTC_1505 k297-0037 20.6 µM 0.68281933733424 0.262412875395159 no 892 0.247360504490078 270 4089396
SGTC_669 0108-0021 26.2 µM 0.682128310659536 0.262624631740649 no 893 0.24757891025114 313 17201
SGTC_1951 sophoraflavanone G 9.2 µM 0.677773062261302 0.263961251527937 no 894 0.248957796655446 271 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_439 amiodarone 34.4 µM 0.676871919228503 0.264238243374116 no 895 0.249243611031178 286 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2119 5528445 120.635 µM 0.676811312852385 0.264256877772163 no 896 0.249262839737514 266 791935
SGTC_3232 9132874 49.47 µM 0.676771839212176 0.264269014932974 no 897 0.249275364042568 259 3784940
SGTC_2297 7971671 152.32 µM 0.676685017447879 0.264295711460932 no 898 0.249302912267831 273 909016
SGTC_305 1682-2595 20.8 µM 0.675866741708312 0.264547387714315 no 899 0.249562627634753 280 226033
SGTC_1769 st044406 64.4 µM 0.6735110777957 0.265272597063438 no 900 0.250311101780066 300 670903
SGTC_430 0958-0115 16.4 µM 0.671506634608014 0.265890474181857 no 901 0.250948917169718 286 6833180
SGTC_2867 9039098 71.43 µM 0.671088609892509 0.266019423707843 no 902 0.251082041269302 271 6463460
SGTC_2628 lathosterol 100 µM 0.670969503006374 0.266056170817667 no 903 0.251119978871473 266 6710616
SGTC_3191 9110352 49.47 µM 0.669803113858213 0.266416163488738 no 904 0.251491654159643 285 17122424
SGTC_472 calcifediol 10 µM 0.66973530041303 0.266437100910804 no 905 0.251513272165093 279 5283731 A vitamin D metabolite.
SGTC_477 mead ethanolamide 10 µM 0.669624092612443 0.266471438155223 no 906 0.251548725827058 244 16061185
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.669614821632703 0.266474300824358 no 907 0.251551681585912 284 688761
SGTC_538 2922-0838 53.3 µM 0.668560296820183 0.266800015750247 no 908 0.251888003201035 272 777039
SGTC_2502 avocadyne acetate 18.59 µM 0.66718255746293 0.26722586605227 no 909 0.252327765604699 257 3952079
SGTC_586 0957-0265 8.15 µM 0.664770078744935 0.267972372911678 no 910 0.253098781596766 279 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2363 9053361 176 µM 0.662613921904927 0.268640452140149 no 911 0.253788925753089 285 6469797 YMR079W SEC14
SGTC_3130 9127414 49.47 µM 0.659381029575815 0.269643720682153 no 912 0.254825560436048 285 1494646
SGTC_1867 st057372 64 µM 0.659363133292481 0.269649279683479 no 913 0.2548313050847 264 688837
SGTC_123 0083-0120 66.675 µM 0.658257559109327 0.269992807992756 no 914 0.255186322201126 296 16001701
SGTC_2584 androsterone 48.74 µM 0.658204393890034 0.270009333213924 no 915 0.255203400897613 254 2754130 A steroid.
SGTC_256 clotrimazole 625 nM 0.656390589171954 0.270573416906681 no 916 0.255786421990134 260 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_93 0109-0045 59.227 µM 0.656026413009367 0.270686744691242 no 917 0.255903564869266 293 88733
SGTC_3098 9119039 49.47 µM 0.655880549080882 0.270732142655976 no 918 0.255950492102462 285 17161528
SGTC_1568 digitonin 820 nM 0.654944819149041 0.271023464977591 no 919 0.256251641191102 309 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_329 k048-0121 21.3 µM 0.654281172976876 0.2712301737573 no 920 0.256465336562598 273 6832902
SGTC_1702 st027038 51 µM 0.654180634083895 0.271261495900373 no 921 0.256497718380081 273 5521182
SGTC_1039 k821-0043 94 µM 0.652620031729665 0.271747921020142 no 922 0.257000634079941 265 15992768
SGTC_1910 st062352 60.4 µM 0.651514044600382 0.272092909492073 no 923 0.257357356973268 286 2245730
SGTC_5 0352-0601 109.883 µM 0.651291590035642 0.272162325617266 no 924 0.257429138096062 283 762456
SGTC_3344 9148862 3.898 µM 0.650546502692235 0.272394891469762 no 925 0.257669636896556 300 4905352
SGTC_466 geldanamycin 89.2 µM 0.649677206631515 0.272666351585867 no 926 0.257950375077717 263 5288382 HSP90 inhibitor.
SGTC_3015 9080845 49.47 µM 0.646886125806817 0.273538845096569 no 927 0.258852822933855 280 5296973
SGTC_531 3788-1495 174 µM 0.646867662378058 0.273544621372627 no 928 0.258858798199526 286 2896655
SGTC_2642 cholecalciferol 100 µM 0.646320376468191 0.273715866953759 no 929 0.25903594714872 286 9821465 A vitamin D precursor, similar to steriods.
SGTC_1866 st057638 64 µM 0.643528224926046 0.274590354776781 no 930 0.259940703190199 282 688802
SGTC_1500 4488-1866 171 µM 0.643039700564651 0.274743499692369 no 931 0.260099169762797 311 2900003
SGTC_1188 1403-0014 4.57 µM 0.639455484263952 0.275868382904759 no 932 0.261263332047321 283 9614867
SGTC_3165 9101544 49.47 µM 0.639261464311076 0.275929339315601 no 933 0.261326426499222 296 5002184
SGTC_158 k038-0087 26.446 µM 0.638865415831254 0.276053788771575 no 934 0.261455244047691 282 X158
SGTC_1985 st071382 65.5 µM 0.637029074102412 0.27663117833546 no 935 0.262052952872583 300 6123237
SGTC_1411 3909-8223 150 µM 0.636023451441766 0.276947620659359 no 936 0.262380568414174 299 X1411
SGTC_354 2783-3500 4.88 µM 0.633245594244263 0.277822657232791 no 937 0.263286637813843 293 6740761
SGTC_626 0214-0009 33 µM 0.632768217606788 0.277973168665585 no 938 0.263442507196417 301 3437874
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.632729809400615 0.277985280066143 no 939 0.263455049998338 290 4213774
SGTC_1781 st038725 66.3 µM 0.631794721231563 0.278280224272254 no 940 0.263760511722667 292 4270275 YIL048W NEO1
SGTC_75 0159-0059 199.013 µM 0.631699359198293 0.278310311802199 no 941 0.263791673424338 336 5377270
SGTC_1326 1431-2094 10.8 µM 0.631050717691361 0.278515005761966 no 942 0.264003681511969 322 616278
SGTC_2784 7567673 72.73 µM 0.630951367943858 0.27854636436814 no 943 0.264036161584099 291 3471247
SGTC_2534 helenine 20.12 µM 0.62868603881334 0.279261855774126 no 944 0.264777309985526 287 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_719 2810-4230 27.3 µM 0.628328784266723 0.279374774084072 no 945 0.264894289546129 294 721079
SGTC_1295 1013-0063 9.78 µM 0.628172665140675 0.279424125997619 no 946 0.264945417496618 298 6826038
SGTC_1483 3453-0561 55.9 µM 0.627879972131083 0.279516662650473 no 947 0.265041285976133 308 4546991
SGTC_2993 9054257 71.4286 µM 0.627114173710186 0.279758844794347 no 948 0.265292198443 296 6470217 YGL055W OLE1
SGTC_2289 7946404 165.07 µM 0.62705891449312 0.279776324343269 no 949 0.26531030868892 292 1246120 YPR165W RHO1
SGTC_289 k017-0060 526 µM 0.626296576894279 0.28001752039004 no 950 0.265560215590365 291 5512909
SGTC_921 1561-0023 372 µM 0.624967657278865 0.280438218224082 no 951 0.265996142774666 290 24050882
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.624779481248618 0.280497814080288 no 952 0.266057899682249 290 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1351 1496-0003 46.5 µM 0.624341719904546 0.280636477990911 no 953 0.266201595311289 292 3891978
SGTC_2319 6033012 152.6 µM 0.622103523028577 0.281345959990905 no 954 0.266936899279409 294 847246
SGTC_1526 st051518 75 µM 0.621989149063676 0.281382238426271 no 955 0.266974501538014 297 673993
SGTC_1478 0453-0656 35.7 µM 0.621035792355661 0.2816847227601 no 956 0.267288036759084 306 5258496
SGTC_2520 obtusaquinone 4.71 µM 0.620938776534413 0.281715513063984 no 957 0.267319953253219 300 5967872
SGTC_3022 9087993 49.47 µM 0.620716267138102 0.281786137899271 no 958 0.267393162181964 298 17173644
SGTC_1154 4088-0362 150 µM 0.618695759973027 0.282427840340111 no 959 0.268058401878148 298 6618304
SGTC_1023 4482-3888 16 µM 0.617591906540904 0.282778715005587 no 960 0.268422190501321 316 3303168
SGTC_984 1492-0255 2.91 µM 0.616525026266905 0.283118036137015 no 961 0.268774029928556 302 1585198
SGTC_2088 5278280 127.392 µM 0.616073049156698 0.283261846294226 no 962 0.26892315431216 301 791502
SGTC_1040 k898-0338 155 µM 0.61598533949733 0.283289757827948 no 963 0.268952097866083 314 20969351
SGTC_1955 wogonin 32.4 µM 0.614366382244761 0.28380518957338 no 964 0.269486622746717 267 5281703 A flavanone.
SGTC_528 3492-0019 172 µM 0.614318298060689 0.283820505126673 no 965 0.26950250665471 309 2869262
SGTC_323 4013-0906 34.3 µM 0.613985305649359 0.283926579195733 no 966 0.269612518709301 271 2910086
SGTC_2844 9010103 25.97 µM 0.613598939950685 0.284049678991651 no 967 0.269740192104721 323 2480525
SGTC_1133 3473-0247 50 µM 0.613114751721151 0.284203982015698 no 968 0.269900233401315 287 711311
SGTC_3241 9133421 49.47 µM 0.613039955269682 0.284227822018587 no 969 0.2699249605058 331 17018221
SGTC_805 3852-0218 479 µM 0.6114589819876 0.284731951924354 no 970 0.270447882673185 281 6615355
SGTC_1596 piperlongumine 63 µM 0.611005172235946 0.284876738456233 no 971 0.270598078085703 279 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1766 st045414 44.774 µM 0.609775367315402 0.285269280196266 no 972 0.27100531052288 322 253960
SGTC_2427 5545055 42.75 µM 0.609764045922943 0.285272895071132 no 973 0.27100906086097 296 5372858
SGTC_2261 9010538 184.68 µM 0.609719428893926 0.285287141320685 no 974 0.271023841003756 331 6457250
SGTC_2279 7948423 32.93 µM 0.609205401384646 0.285451295116154 no 975 0.271194150274884 272 1247112
SGTC_126 0417-1624 672.48 µM 0.605492817195153 0.286638235871106 no 976 0.272425797911836 325 41912 YDL195W SEC31
SGTC_2595 hexamethylquercetagetin 100 µM 0.60034691957048 0.288287277486664 no 977 0.274137527646842 322 386331
SGTC_311 1315-0136 58 µM 0.598534890697937 0.288869019006948 no 978 0.274741542688071 306 6759207
SGTC_1818 st052136 56.3 µM 0.598445768418304 0.288897645455495 no 979 0.274771267302895 292 674169
SGTC_765 1319-0117 244 µM 0.59679155187432 0.289429228921701 no 980 0.275323279504521 292 3487746 YGL099W LSG1
SGTC_2878 9043973 25.97 µM 0.596616384691207 0.289485545892511 no 981 0.275381764749687 317 6465167
SGTC_427 1354-0053 47.3 µM 0.594831567382534 0.290059665172356 no 982 0.275978032131848 316 6813657
SGTC_1550 gossypolone 36.6 µM 0.593132706385296 0.290606630289544 no 983 0.276546171811499 302 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1827 berberine 7.24 µM 0.592645854738989 0.290763465907245 no 984 0.276709092263941 287 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3199 9111318 49.47 µM 0.591005135883191 0.291292302440222 no 985 0.27725848988136 298 8548020
SGTC_2715 st079500 56.4 µM 0.590668304231421 0.291400925540961 no 986 0.27737134453104 297 28246688
SGTC_310 1273-0058 1.06 µM 0.587758300630912 0.292340143518832 no 987 0.278347268493464 277 2734232
SGTC_1843 st055809 45.5 µM 0.587712198250287 0.292355034610516 no 988 0.27836274324394 299 16413835
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.584746748361196 0.293313616519106 no 989 0.27935900772124 311 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3251 9135047 49.47 µM 0.584225905869497 0.293482129167311 no 990 0.279534167223958 288 17682963
SGTC_2389 9091542 195.52 µM 0.58399460307103 0.293556978925774 no 991 0.279611971526999 302 3626624 YOL127W RPL25
SGTC_2868 9035608 32.47 µM 0.583632682717387 0.293674114355936 no 992 0.279733733299147 312 6462614
SGTC_1937 st074714 47.2 µM 0.583061301565392 0.29385908574497 no 993 0.279926016849008 305 17250970
SGTC_29 0299-0004 12.984 µM 0.582493721311278 0.294042880017581 no 994 0.280117084737173 296 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2276 7947513 42.08 µM 0.579579131304155 0.294987520758396 no 995 0.281099234699208 302 2105100
SGTC_803 4488-1585 147 µM 0.579456593170344 0.295027266907019 no 996 0.281140563651072 301 747204
SGTC_194 1486-1323 56.904 µM 0.579033748221141 0.295164438729156 no 997 0.28128320087902 313 5178754
SGTC_1254 0550-0035 264 µM 0.578739278305334 0.295259982753097 no 998 0.281382554310845 309 15121435
SGTC_224 benfluorex 43.875 µM 0.578620917414979 0.295298390264567 no 999 0.281422493758101 325 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1928 4'-methoxychalcone 40.3 µM 0.575905111369497 0.296180286520947 no 1000 0.282339660272945 329 641818
SGTC_369 0957-0393 4.5 µM 0.570886516463872 0.297813132304232 no 1001 0.284038285744619 313 6997992
SGTC_1333 1482-0047 286 µM 0.57005082676179 0.298085429860901 no 1002 0.284321612705328 329 3811116
SGTC_2443 5493264 126.67 µM 0.569990591625039 0.298105061002257 no 1003 0.284342039663576 331 5340055
SGTC_521 r062-0005 13.8 µM 0.569903743069035 0.298133366719243 no 1004 0.284371493007399 302 2832033
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.569758855703866 0.298180591193627 no 1005 0.284420632559876 310 75037 A free radical scavenger.
SGTC_44 0929-0055 61.211 µM 0.569537836664876 0.298252636528318 no 1006 0.284495600510212 301 1379590
SGTC_1481 3346-2004 36 µM 0.568573408077314 0.298567102976831 no 1007 0.284822837640979 334 2770522
SGTC_544 k015-0020 52.4 µM 0.566490912520015 0.299246645832515 no 1008 0.285530054399821 312 3008304
SGTC_664 1222-0054 14.9 µM 0.566396839808344 0.299277359426978 no 1009 0.285562021272755 304 6813991
SGTC_1473 k844-0725 134 µM 0.566360038679115 0.299289374936541 no 1010 0.285574527137687 313 54682906
SGTC_1762 st045503 25.4615 µM 0.566019908292477 0.299400437317841 no 1011 0.285690123553964 309 4645554
SGTC_575 k072-0246 11.9 µM 0.565491667044934 0.299572960361203 no 1012 0.285869695284448 308 6796779
SGTC_2424 5537928 59.2 µM 0.565220267362125 0.299661616731796 no 1013 0.285961976477198 313 5382802
SGTC_487 nimodipine 119 µM 0.564782814086259 0.299804541764356 no 1014 0.286110748932483 312 4497 L-type voltage-gated calcium channels inhibitor
SGTC_381 3461-2219 42.7 µM 0.562667764710898 0.300496007098472 no 1015 0.286830569288405 343 2883159
SGTC_2218 6965428 192.983 µM 0.561894423498367 0.300749012410573 no 1016 0.287093976666503 311 675684
SGTC_2475 5812728 15.03 µM 0.561180336855248 0.300982717392452 no 1017 0.287337303039626 313 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_597 k018-0003 82.8 µM 0.56000402371478 0.301367877437043 no 1018 0.287738346579593 337 6786234
SGTC_2943 9068529 45.32 µM 0.557951743738497 0.302040385877202 no 1019 0.288438668311565 334 3270634
SGTC_703 3875-0075 71.8 µM 0.556379967019247 0.30255589421736 no 1020 0.288975565396198 343 2850814
SGTC_742 0kpi-0133 140 µM 0.556266044148608 0.302593273747207 no 1021 0.289014498133369 327 2728852
SGTC_3206 9114350 49.47 µM 0.555721541307693 0.302771960571199 no 1022 0.289200614121101 299 17087243
SGTC_623 k072-0108 16.9 µM 0.554067920532274 0.303314910632153 no 1023 0.289766181749458 334 5382803
SGTC_3351 9150312 21.596 µM 0.554057647543225 0.303318285026531 no 1024 0.289769696915318 315 4904905
SGTC_1064 honokiol 6.76 µM 0.553852444236228 0.303385692184077 no 1025 0.289839916664461 325 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2434 5670830 169.91 µM 0.553267310331334 0.303577939347318 no 1026 0.29004019096034 334 1549830
SGTC_1047 2043-3044 82 µM 0.552639835476558 0.303784158152247 no 1027 0.290255029383766 359 669592
SGTC_3119 9125183 49.47 µM 0.552317264934902 0.303890194864664 no 1028 0.290365501929556 294 22695334
SGTC_21 0849-0113 22.993 µM 0.551474487234403 0.304167314081752 no 1029 0.290654225619309 300 1560156
SGTC_1401 3807-4679 7.6 µM 0.550074969713696 0.304627747072658 no 1030 0.291133976915802 329 3291456
SGTC_2149 5554786 194.827 µM 0.54895153364606 0.304997575032271 no 1031 0.291519355508423 315 745063 YPR165W RHO1
SGTC_2936 9038235 15.59 µM 0.546473363716868 0.305814076898638 no 1032 0.292370296222044 309 4749415
SGTC_2384 9036245 200 µM 0.54432114349221 0.306523969791297 no 1033 0.293110249835717 295 6462766
SGTC_226 1,3-diallylurea 8.28947 mM 0.544013120515449 0.3066256282424 no 1034 0.293216222047875 312 74537 YKL182W FAS1
SGTC_1367 1812-0510 76.9 µM 0.543066487230585 0.30693814373212 no 1035 0.293542012848886 306 1142582 YDR527W RBA50
SGTC_2453 5731132 22.18 µM 0.542912648555791 0.30698894431575 no 1036 0.293594973389405 338 1362040
SGTC_1003 4049-0218 100 µM 0.541340289787685 0.307508380750775 no 1037 0.294136527511929 327 295161
SGTC_1915 st067105 30.6 µM 0.539128264680074 0.30823978787399 no 1038 0.294899176968953 324 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3070 9117005 49.47 µM 0.538604261684817 0.308413161450096 no 1039 0.295079973169728 328 8779016
SGTC_2237 6667747 47.222 µM 0.538501236687996 0.308447253711269 no 1040 0.295115525780074 358 729940 YDL015C TSC13
SGTC_3169 9102970 49.47 µM 0.537887330574921 0.308650437168051 no 1041 0.295327417824025 332 17027839
SGTC_975 1335-0046 28.5 µM 0.537705102306298 0.308710760227842 no 1042 0.295390328080159 334 16486740
SGTC_972 1319-0219 195 µM 0.537029199575455 0.308934549512895 no 1043 0.295623722287792 331 23903702
SGTC_683 panaxydol 45 µM 0.536986702446778 0.308948622550938 no 1044 0.295638399692406 302 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_278 4092-0821 23.9 µM 0.536965206792429 0.308955741001285 no 1045 0.295645823860745 317 877900
SGTC_1438 4092-1045 4 µM 0.536098047431084 0.309242967264259 no 1046 0.295945394761131 328 1351342
SGTC_395 anisomycin 6.25 µM 0.534769002768982 0.30968340853316 no 1047 0.296404799933125 349 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_633 0437-0093 97.7 µM 0.534765415979914 0.309684597554104 no 1048 0.296406040205329 332 2831118
SGTC_121 0557-0495 61.343 µM 0.534026089942291 0.309929726709114 no 1049 0.296661741782765 340 3104427
SGTC_671 0560-0003 407 µM 0.533820665855885 0.309997851632366 no 1050 0.296732807208025 343 3238678
SGTC_1078 idebenone 36.1 µM 0.533494350532403 0.310106081206359 no 1051 0.296845710367945 337 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3219 9131112 49.47 µM 0.533031021800425 0.310259782522029 no 1052 0.297006053119399 306 17612988 YMR079W SEC14
SGTC_1122 capsaicin 818.572 nM 0.531773166355697 0.310677221464804 no 1053 0.297441554926829 354 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1502 4534-4282 27.7 µM 0.53170815122991 0.310698804380332 no 1054 0.297464072754801 350 3278949
SGTC_801 0866-0028 10.1 µM 0.531628014446202 0.31072540809279 no 1055 0.297491829002647 321 6849771
SGTC_3174 9107204 49.47 µM 0.531148019201528 0.31088477704577 no 1056 0.297658105332926 333 3938802
SGTC_2325 6158266 200 µM 0.525540266038456 0.312749296318479 no 1057 0.299603834674061 308 3623240
SGTC_3153 9100258 49.47 µM 0.525116908887321 0.312890253644769 no 1058 0.299750961143131 353 25236848
SGTC_870 0573-2213 57.6 µM 0.524499486207718 0.313095874389996 no 1059 0.299965588538232 314 3916321
SGTC_1227 3909-8010 46.6 µM 0.523455412466102 0.313443715322054 no 1060 0.300328685768297 316 15982272
SGTC_952 1185-0122 232 µM 0.521014865883981 0.314257448649284 no 1061 0.301178207751232 318 678600
SGTC_2285 7945142 200 µM 0.520037664787576 0.314583523117288 no 1062 0.301518661779043 346 2970608
SGTC_740 k014-0057 261 µM 0.519594655869818 0.314731394917657 no 1063 0.301673061825856 352 4012779
SGTC_3161 9100388 49.47 µM 0.519295205287379 0.314831365261386 no 1064 0.30177744822075 341 25236368
SGTC_3266 9136860 49.47 µM 0.518686485181861 0.315034625787943 no 1065 0.301989693858382 343 4871271 YPR165W RHO1
SGTC_186 3455-3465 67.277 µM 0.517162862444725 0.315543631165321 no 1066 0.30252123710944 335 755278
SGTC_893 0958-0369 48.9 µM 0.517003287137192 0.315596961676534 no 1067 0.302576932086881 354 6819948
SGTC_1105 epirubicin 18.1 µM 0.516729667934241 0.315688414912505 no 1068 0.302672441361215 329 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_11 0438-0307 1.3 µM 0.516014342419755 0.315927555367255 no 1069 0.302922196035049 346 4011476
SGTC_2978 9011784 42.97 µM 0.514663536866771 0.316379353224572 no 1070 0.303394078858323 335 2994934
SGTC_1250 0485-0349 40.2 µM 0.512350737794696 0.317153541131897 no 1071 0.304202780703804 340 6842794 YDL195W SEC31
SGTC_668 1682-0499 62.6 µM 0.511060933297572 0.317585639276074 no 1072 0.304654195172956 331 682214
SGTC_2331 7980721 200 µM 0.509749135788943 0.31802536035426 no 1073 0.305113612214041 340 2981221
SGTC_861 0443-0273 110 µM 0.507600361112232 0.318746194712039 no 1074 0.305866818667787 342 6149169
SGTC_233 rapamycin 362 pM 0.505941122374099 0.319303277678381 no 1075 0.306448991446246 313 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2638 epoxomicin 18 µM 0.504709631756296 0.319717009873452 no 1076 0.30688139752784 359 9915668 A protesome inhibitor.
SGTC_848 0368-0089 85.6 µM 0.503167444107684 0.320235440482896 no 1077 0.307423275919311 346 762535
SGTC_2430 5571206 200 µM 0.500625407157508 0.3210907521728 no 1078 0.30831738898767 342 1731771
SGTC_832 4083-0019 164 µM 0.499842957202485 0.321354212241071 no 1079 0.308592830220337 332 1990758
SGTC_1617 st002906 78 µM 0.498445401493631 0.321825009281067 no 1080 0.309085071507461 358 5150859
SGTC_245 methotrexate 289.6 µM 0.498414981708035 0.321835260032629 no 1081 0.309095789655439 321 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1662 st014054 52 µM 0.498099282433557 0.321941651260155 no 1082 0.309207033153648 337 2838777
SGTC_524 r073-0010 27.8 µM 0.497816405465264 0.322036993710815 no 1083 0.309306725860086 359 2772106
SGTC_302 1094-0063 18.9 µM 0.497567590705997 0.322120865325819 no 1084 0.309394425823596 343 5440289
SGTC_2571 chrysanthemic acid 100 µM 0.496751772159888 0.32239592869641 no 1085 0.309682054270345 359 2743 An insecticide.
SGTC_249 wiskostatin 11.211 µM 0.496167516745564 0.32259297745725 no 1086 0.30988811349119 330 2775510 A n-wasp and actin depolymerizer.
SGTC_3275 9138069 49.47 µM 0.495652352839817 0.32276676543656 no 1087 0.310069854608185 333 17617007
SGTC_2927 9011802 47.9 µM 0.495212580186334 0.322915151186224 no 1088 0.310225035688173 339 43912568
SGTC_682 0kpi-0099 17 µM 0.494032351303128 0.323313517049288 no 1089 0.310641666046832 334 1714895 YML126C ERG13
SGTC_908 3448-7491 47.7 µM 0.493672729085063 0.323434941619635 no 1090 0.310768663925534 299 1203031
SGTC_167 3672-0051 66.205 µM 0.491842907827938 0.324053062309999 no 1091 0.311415200516197 359 3237971
SGTC_1358 1509-0022 2.48 µM 0.490926091481539 0.324362949056211 no 1092 0.311739361174749 349 3258434
SGTC_2872 9044037 25.97 µM 0.489976333621379 0.324684098457747 no 1093 0.312075322923462 360 6465195
SGTC_2718 lomofungin 53.02 µM 0.488168308957394 0.325295820834951 no 1094 0.312715314924493 342 5351222 A RNA synthesis inhibitor.
SGTC_248 streptozotocin 5.23457 mM 0.487563136171997 0.325500678729896 no 1095 0.312929656092052 350 5300 DNA alkylating agent.
SGTC_3141 9094609 49.47 µM 0.486132022551896 0.32598533670845 no 1096 0.313436781991129 356 25236309 YDL196W YDL196W
SGTC_2016 5121758 140 µM 0.486053491935241 0.326011940245049 no 1097 0.313464620129159 335 2795203
SGTC_1127 asiatic acid 681.4 nM 0.485599776530125 0.326165661129628 no 1098 0.313625477462123 341 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_261 5-fluorouridine 15.376 µM 0.485127958606992 0.326325546564103 no 1099 0.313792790338834 317 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_41 0478-0632 82.643 µM 0.48469889256372 0.326470972338211 no 1100 0.313944976086648 379 3750424
SGTC_2396 5342950 42.78 µM 0.484662668478315 0.326483251179609 no 1101 0.313957825883185 334 1886677
SGTC_3278 9139605 49.47 µM 0.483653981436423 0.326825240268119 no 1102 0.314315728739378 349 7958859
SGTC_1887 st057648 70.8 µM 0.483245347558172 0.326963826487081 no 1103 0.314460770145969 359 688672
SGTC_3243 9134147 49.47 µM 0.482591847042386 0.327185507652811 no 1104 0.314692784580996 351 24282180
SGTC_771 0250-0039 27.3 µM 0.482086545459802 0.327356958420068 no 1105 0.314872233636226 367 3005115
SGTC_1195 1502-0147 41.1 µM 0.481354826269931 0.32760529810913 no 1106 0.315132168443946 331 817940
SGTC_948 3448-0295 75.3 µM 0.479352350494397 0.328285312299164 no 1107 0.315843992760882 334 678569
SGTC_1837 st055472 66.5 µM 0.478646793294327 0.328525045921744 no 1108 0.316094961654396 326 676091
SGTC_2311 7694451 200 µM 0.477743495698088 0.328832070659706 no 1109 0.316416391144914 377 2163142
SGTC_394 menadione 8.33 µM 0.475375353526795 0.329637534273338 no 1110 0.317259729186844 351 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1011 4112-3381 17.4 µM 0.473202692153656 0.330377205874505 no 1111 0.318034288632163 355 2877139
SGTC_1396 3511-0007 98.6 µM 0.472006481324215 0.330784733112318 no 1112 0.318461081185051 356 X1396
SGTC_2710 st078562 53.7235 µM 0.471958635208739 0.330801037588428 no 1113 0.318478157076849 361 17250908
SGTC_9 0092-0002 10.449 µM 0.468686249141465 0.331916925843289 no 1114 0.319646958644264 358 759368
SGTC_1216 1165-0504 9.65 µM 0.466071142434674 0.332809754591458 no 1115 0.320582289200393 356 6304004
SGTC_1199 1638-0010 4.46 µM 0.465219604149007 0.333100685006915 no 1116 0.320887100561778 347 3111136
SGTC_2333 9017922 200 µM 0.465190046931244 0.333110785117509 no 1117 0.320897682849903 350 3163164
SGTC_3121 9125696 49.47 µM 0.465108552000992 0.333138633690631 no 1118 0.320926861005811 386 1235365
SGTC_1303 1160-0052 261 µM 0.462600961277644 0.333995980539011 no 1119 0.321825209744653 354 3562476
SGTC_509 pifithrin 175 µM 0.462196270578662 0.334134425922158 no 1120 0.321970288725633 378 4817 A p53 inhibitor.
SGTC_1862 st057513 3.81 µM 0.460479164719845 0.334722101658114 no 1121 0.322586161641959 347 5393163
SGTC_262 fenpropimorph 62.5 µM 0.460088366633924 0.334855908088173 no 1122 0.322726396967978 365 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1616 st002734 56.1 µM 0.459720447361678 0.334981900142398 no 1123 0.322858445427891 357 4026101
SGTC_1820 st053765 18.6 µM 0.459327664948737 0.335116426949111 no 1124 0.322999442071307 343 3690829
SGTC_234 nsc-17383 10.7 µM 0.457549705641628 0.335725637091113 no 1125 0.323637992005316 350 408974
SGTC_1656 st012921 11 µM 0.456524221359834 0.336077211437381 no 1126 0.324006528701465 358 6732821
SGTC_2869 9037858 32.47 µM 0.4561117158524 0.336218674220714 no 1127 0.324154822877073 341 27187042
SGTC_3222 9128301 49.47 µM 0.455947714547335 0.336274922535756 no 1128 0.324213788481662 336 4911358
SGTC_866 0495-0101 262 µM 0.452927443821614 0.337311453447849 no 1129 0.325300494240184 356 635694
SGTC_519 k048-0011 62.8 µM 0.452252395647409 0.33754329344316 no 1130 0.325543583011696 344 6836379
SGTC_1129 3453-1384 223 µM 0.452100307307158 0.33759553550575 no 1131 0.325598361155434 378 1084452
SGTC_288 1315-0019 35.1 µM 0.450628033374887 0.338101420539377 no 1132 0.32612882933008 368 6811474
SGTC_2284 7945075 39.21 µM 0.449833586609305 0.338374520322059 no 1133 0.32641521904841 374 1245402
SGTC_728 3030-5151 22.5 µM 0.448899655170256 0.338695678233131 no 1134 0.326752022418193 357 3125388
SGTC_2401 5128683 200 µM 0.447587470028019 0.339147107219958 no 1135 0.327225473851513 369 708373
SGTC_3337 9144342 33.5465 µM 0.446678426709489 0.339459979463513 no 1136 0.32755363022745 327 17682949
SGTC_1050 3232-1156 69.3 µM 0.446424162640419 0.339547511250276 no 1137 0.327645441107 349 700529
SGTC_1144 3486-0183 12.5 µM 0.444129066283185 0.340338001826125 no 1138 0.328474636451814 389 6744069
SGTC_851 0394-0702 453 µM 0.443820520210941 0.340444326691193 no 1139 0.328586175621858 373 762646
SGTC_1041 0206-0046 107 µM 0.44367097629791 0.340495864033526 no 1140 0.328640241128853 359 50494
SGTC_2404 5161160 200 µM 0.442780127870359 0.340802938962217 no 1141 0.328962389201644 374 2831543
SGTC_2258 7960471 200 µM 0.441476024397787 0.341252652917104 no 1142 0.329434207467465 373 2974708
SGTC_1905 st060207 84.5 µM 0.441350631520274 0.341295905958103 no 1143 0.329479588327529 356 1948547
SGTC_2053 5265679 138 µM 0.438731231863345 0.342199918066314 no 1144 0.330428147011173 352 764595
SGTC_3260 9137109 49.47 µM 0.438458223101834 0.342294191532008 no 1145 0.330527074058709 349 17478346
SGTC_1944 st076371 56.9 µM 0.4381473249339 0.342401560670236 no 1146 0.330639745076661 348 24208455
SGTC_977 1348-1378 135 µM 0.436340546342379 0.343025786188056 no 1147 0.331294833996584 361 X977
SGTC_2466 5983409 37.09 µM 0.436098278535005 0.343109520134949 no 1148 0.331382713055018 366 2879657
SGTC_3163 9099914 49.47 µM 0.435027040305677 0.343479859750613 no 1149 0.331771400094854 384 16268368
SGTC_1504 k297-0033 30 µM 0.434042813301089 0.343820251075092 no 1150 0.332128675775659 334 4388117
SGTC_373 0844-0104 25.9 µM 0.433769678121776 0.343914736342481 no 1151 0.332227851273299 369 5375804
SGTC_318 1488-0629 67.2 µM 0.431515154795942 0.344695012258032 no 1152 0.333046917880929 392 3662576
SGTC_2857 9024691 58.44 µM 0.430873063124906 0.344917357131805 no 1153 0.333280335301722 382 16478292
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.430161008633234 0.345163991516741 no 1154 0.333539261593178 371 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_215 1287-0124 461.5 µM 0.429178599113781 0.345504376769176 no 1155 0.333896628002174 376 5560863
SGTC_3209 9113616 49.47 µM 0.428053673976353 0.345894294302859 no 1156 0.334306021706547 396 16649353
SGTC_2083 5306046 65.942 µM 0.427642164879673 0.346036970979444 no 1157 0.334455831383174 339 539837
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.426586630989157 0.346403041090699 no 1158 0.334840218457 400 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_423 5-fluorouracil 457 µM 0.423277216768395 0.347551709327696 no 1159 0.336046507480258 352 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.422333824782608 0.347879409401712 no 1160 0.336390686200458 397 1273210
SGTC_1839 st053978 48 µM 0.422062370437472 0.347973723839739 no 1161 0.336489746605382 370 3788398
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.420842391407315 0.348397710936598 no 1162 0.336935087173151 387 688667
SGTC_3256 9138902 49.47 µM 0.4187765795297 0.349116087614843 no 1163 0.337689711396156 386 17228773
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.418573350370443 0.349186788901125 no 1164 0.337763984679427 379 551469
SGTC_1363 1636-0063 10.4 µM 0.414045179710835 0.350763445437288 no 1165 0.339420509768493 366 6072185
SGTC_162 k030-0015 37.8 µM 0.413879160790907 0.350821300371889 no 1166 0.33948130314743 395 1809920 YMR134W ERG29
SGTC_2346 9031566 143.75 µM 0.412470637547183 0.351312287216052 no 1167 0.339997248956734 383 4771086
SGTC_2854 9024559 71.43 µM 0.411828811840537 0.351536098940002 no 1168 0.340232450913746 371 3163529
SGTC_252 miconazole 1.30953 nM 0.411178453181907 0.351762938708806 no 1169 0.340470843258941 367 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_355 1311-2252 105 µM 0.40980992766384 0.35224044150343 no 1170 0.340972691535848 370 5338538
SGTC_2129 girgensonine 121.053 µM 0.408890193507193 0.352561484026645 no 1171 0.341310122982795 381 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1170 0310-0127 64.8 µM 0.407574593263695 0.353020890178639 no 1172 0.341793010074913 400 774975
SGTC_396 dithiazanine 1.25 µM 0.404550574689489 0.354077685744294 no 1173 0.342903947668957 352 10578 An antihelmenthic.
SGTC_2062 5245942 200 µM 0.404178549915937 0.354207774107238 no 1174 0.343040713002045 373 1376160
SGTC_799 1310-0557 151 µM 0.404094948986848 0.354237009738993 no 1175 0.343071449562611 394 5354492
SGTC_2667 digitoxin 100 µM 0.403805852122826 0.35433811487124 no 1176 0.343177746375472 352 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2841 9004761 38.96 µM 0.403477523762603 0.354452952788798 no 1177 0.343298483102183 333 2991039
SGTC_1600 coumarin 106 71.1 µM 0.402607922637107 0.354757173134399 no 1178 0.343618340208121 403 100336 A hepatotoxic, DNA x-linker.
SGTC_1897 st060201 15 µM 0.402135839032018 0.354922365181856 no 1179 0.343792029147231 365 611878
SGTC_2068 5226020 147 µM 0.39627549966987 0.356975284230479 no 1180 0.345950899703193 370 1810509
SGTC_2836 9010338 19.48 µM 0.395311781415589 0.357313280434258 no 1181 0.346306402855254 349 2994051
SGTC_580 1123-0028 41 µM 0.392950328890436 0.358141964258786 no 1182 0.347178084099655 382 1677248 YPR107C YTH1
SGTC_1819 st053448 58.6 µM 0.392026391539386 0.358466375723685 no 1183 0.347519356896327 390 2857616
SGTC_1435 4092-0789 56.7 µM 0.390658175859505 0.358946969135185 no 1184 0.348024958874688 393 2248285
SGTC_1633 st005664 67.9 µM 0.390420037817841 0.359030639296169 no 1185 0.348112986578443 372 2063822
SGTC_2432 5630864 12.22 µM 0.389355722608039 0.359404670661052 no 1186 0.34850651056504 381 5714970
SGTC_1722 st034304 3.6505 µM 0.387633441519602 0.360010215743058 no 1187 0.349143658743062 384 4036148 YLR033W RSC58
SGTC_1 0258-0098 57.368 µM 0.384811504576326 0.361003153286666 no 1188 0.350188537434185 344 6790032 YDR047W HEM12
SGTC_1267 0828-0272 9.49 µM 0.384596530981429 0.361078833229251 no 1189 0.350268182340277 374 745334
SGTC_2962 9082311 13.18 µM 0.384288264818785 0.361187365654358 no 1190 0.350382402414035 383 16459453
SGTC_1521 st012942 49.4 µM 0.384270218520826 0.361193719628548 no 1191 0.350389089423534 357 24207259
SGTC_2601 securinine 100 µM 0.384205140362179 0.361216633507111 no 1192 0.350413204353703 385 442872 A GABA receptor antagonist.
SGTC_2717 st081029 62.2815 µM 0.3837531270892 0.361375800136717 no 1193 0.350580716023014 409 5292846
SGTC_1337 1486-1011 40.3 µM 0.381810049565854 0.362060285550612 no 1194 0.35130113201205 370 X1337
SGTC_815 1582-0027 36.9 µM 0.381782574232822 0.362069967420609 no 1195 0.351311322613574 385 3128206
SGTC_2703 st077852 53.4 µM 0.380739329711485 0.36243765542906 no 1196 0.351698341053087 378 6281836
SGTC_3326 9140064 16.379 µM 0.38018219115805 0.362634069045658 no 1197 0.351905088961851 380 1868434
SGTC_619 1652-1634 108 µM 0.378426351165989 0.363253309145293 no 1198 0.352556947870745 382 5400454
SGTC_3014 9081533 49.47 µM 0.374389936531778 0.364678203472029 no 1199 0.354057114472687 417 21367265
SGTC_750 4073-0104 132 µM 0.373720378493516 0.364914745578317 no 1200 0.354306181157384 382 22330957
SGTC_1365 1672-3266 55.4 µM 0.373342522549306 0.365048257592865 no 1201 0.3544467660624 412 6415873
SGTC_979 1426-2828 121 µM 0.372358469068562 0.365396040836123 no 1202 0.354812985581245 389 747872
SGTC_2587 piperic acid 92.2 µM 0.372033520040726 0.3655109083406 no 1203 0.354933946180481 379 5370536
SGTC_1005 4092-0690 4.4 µM 0.372020123285549 0.365515644271033 no 1204 0.354938933367442 388 1529343
SGTC_1565 sinapyl alcohol 95.1 µM 0.371903969029253 0.365556707198875 no 1205 0.354982174954163 405 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2118 5526350 200 µM 0.371712835667623 0.365624280142172 no 1206 0.355053333621455 383 743594
SGTC_2127 5253358 187.912 µM 0.3716671893332 0.365640418481726 no 1207 0.355070328432085 386 20612
SGTC_881 0833-0569 170 µM 0.37136029696741 0.365748926975419 no 1208 0.35518459651804 360 5418700
SGTC_1458 k015-0034 6.33 µM 0.370699244184606 0.36598269309365 no 1209 0.355430776670599 384 3598957
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.369962590362043 0.366243252401582 no 1210 0.355705182193653 379 2374 Ca(2+)-ATPase inhibitor.
SGTC_1321 1326-2144 215 µM 0.369736400261334 0.366323269712701 no 1211 0.355789453627086 409 3513030
SGTC_95 0471-0001 561.058 µM 0.368546952256238 0.366744145995879 no 1212 0.356232721046964 355 4015405
SGTC_1400 3771-8998 51.5 µM 0.367440153360158 0.367135921537812 no 1213 0.356645362492689 404 670767
SGTC_1104 tacrolimus 29.8 µM 0.366966644652049 0.367303572533959 no 1214 0.356821949302189 391 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_707 0865-0008 204 µM 0.365260875657249 0.36790772844105 no 1215 0.357458340223397 388 723043
SGTC_610 4215-0184 155 µM 0.364726574096377 0.368097036759844 no 1216 0.357657759923028 396 5605015
SGTC_1368 1852-0141 284 µM 0.363300990464462 0.368602291773433 no 1217 0.358190026767851 387 2838987
SGTC_2664 lyso-paf C-16 73.48 µM 0.361783938526879 0.369140214543915 no 1218 0.358756747745686 392 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_125 0133-0007 11.75 µM 0.361099336055876 0.369383047833503 no 1219 0.35901259478334 418 26541
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.360759555334233 0.369503589794535 no 1220 0.359139599840196 389 676296 Flavone; oxidizing agent.
SGTC_1024 4507-0395 26 µM 0.360693391124592 0.369527063965456 no 1221 0.359164332864062 366 4201836
SGTC_1984 st072354 53.1 µM 0.360692770409942 0.369527284188961 no 1222 0.359164564897895 410 5762938
SGTC_2316 5844804 197.44 µM 0.359963845878567 0.369785929027032 no 1223 0.359437085279412 393 776813
SGTC_119 0121-0043 24.815 µM 0.358325167767238 0.370367597368975 no 1224 0.360049992852809 387 1092378
SGTC_779 1360-0071 233 µM 0.357806033857207 0.370551932057053 no 1225 0.360244237383947 389 7566
SGTC_446 go6976 132 µM 0.356312903840865 0.371082279999807 no 1226 0.360803123392073 422 3501 A protein kinase C inhibitor.
SGTC_1547 harmine 94.2 µM 0.356083968455981 0.371163617715256 no 1227 0.360888841371933 387 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_636 0kpi-0074 126 µM 0.355766284959843 0.371276495995015 no 1228 0.361007799992605 383 616434
SGTC_2674 ligustilide 100 µM 0.355008725564743 0.371545714237712 no 1229 0.361291527203101 388 5319022 A signalling regulator.
SGTC_787 4152-0075 138 µM 0.354873319279593 0.371593840972767 no 1230 0.36134224869276 371 9566539
SGTC_573 3702-0553 84.7 µM 0.354251800025183 0.371814769992043 no 1231 0.361575093237139 375 1222756
SGTC_140 0062-0056 502.533 µM 0.353003346385584 0.372258680439275 no 1232 0.36204296589292 357 3758964
SGTC_1201 1889-3372 45.9 µM 0.352468328694699 0.372448967741035 no 1233 0.362243533219587 385 5392199
SGTC_2612 dictamnine 15.46 µM 0.348678642210767 0.373797717296762 no 1234 0.363665290106752 404 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2553 4-methylesculetin 85.09 µM 0.348330653347055 0.373921644336792 no 1235 0.363795937781734 382 5319502
SGTC_1450 4112-4260 37.6 µM 0.348010201827717 0.374035776206921 no 1236 0.363916260943631 411 1633175
SGTC_2172 5754775 163.918 µM 0.347932886068504 0.374063314607215 no 1237 0.363945293480861 382 2263357
SGTC_2566 crystal violet carbinol 226 nM 0.347877494519683 0.374083044416689 no 1238 0.363966093824126 431 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_468 gf-109203x 121 µM 0.344577772920088 0.375258959312681 no 1239 0.365205909080205 397 2396 A protein kinase C inhibitor.
SGTC_3184 9108758 49.47 µM 0.344275784223464 0.375366636504799 no 1240 0.365319446917412 398 902885
SGTC_1376 2910-0861 41.3 µM 0.342521727237234 0.375992255426448 no 1241 0.365979147891441 390 1112859
SGTC_542 3381-0244 89.3 µM 0.342417872826752 0.376029307384815 no 1242 0.366018219993249 439 1112843
SGTC_1747 st037496 66.6 µM 0.341331105898701 0.376417099832667 no 1243 0.366427166675628 374 723305
SGTC_2268 7933382 153.85 µM 0.341316482036221 0.376422318936065 no 1244 0.366432670620648 361 935025 YOR257W CDC31
SGTC_2173 5763948 167 µM 0.34114758926252 0.376482596635584 no 1245 0.366496238344383 414 2867177
SGTC_1070 indatraline 8.81 µM 0.335581316014685 0.37847087257566 no 1246 0.368593307702791 424 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3008 9078912 71.4286 µM 0.335122695097563 0.378634836596046 no 1247 0.368766266769071 416 16648731
SGTC_2519 cryptotanshinone 88.04 µM 0.334985424638238 0.378683917143036 no 1248 0.368818040556655 381 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3035 9091303 49.47 µM 0.333761869542689 0.379121481123556 no 1249 0.369279629358942 402 25237002
SGTC_2367 9070478 135.38 µM 0.333451540918026 0.379232484536445 no 1250 0.369396731500872 397 572802
SGTC_1620 st003704 16.5 µM 0.332199480037273 0.379680443180014 no 1251 0.369869318178949 402 2834414
SGTC_1745 st081495 74 µM 0.331251169684667 0.380019834394662 no 1252 0.370227385999994 388 13842402 YBL026W LSM2
SGTC_890 0929-0006 47.2 µM 0.331186678664956 0.380042918473564 no 1253 0.370251740934146 383 1378169
SGTC_1844 rapamycin 4 nM 0.326231010135446 0.381818035357226 no 1254 0.37212479048931 384 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_375 3970-0961 9.27 µM 0.325732799033324 0.381996632459397 no 1255 0.372313263203395 383 2898222
SGTC_1385 3091-4834 14.1 µM 0.325466998716397 0.382091925972428 no 1256 0.37241382768761 398 4072814
SGTC_2272 7805186 180 µM 0.321921911387865 0.383363575310804 no 1257 0.373755926601095 446 2956062 YPR165W RHO1
SGTC_2958 9077254 16.72 µM 0.31914366180895 0.384361033997819 no 1258 0.374808788027992 381 16457351
SGTC_1901 st060216 58.6 µM 0.318852704749587 0.384465539044409 no 1259 0.374919104939476 390 688792
SGTC_1941 st076221 61.8 µM 0.317681678685212 0.384886229363719 no 1260 0.375363205060296 380 2828568
SGTC_1339 1486-1321 22.7 µM 0.316221643579207 0.385410935806672 no 1261 0.375917140402311 406 3469382
SGTC_892 0929-0076 29 µM 0.31599324346898 0.385493037088627 no 1262 0.376003818260529 397 5751038
SGTC_1479 0549-0158 134 µM 0.314772991901334 0.385931758663424 no 1263 0.376467009713949 379 5440202
SGTC_2378 9074213 121.43 µM 0.314666153813629 0.385970177513419 no 1264 0.376507572528575 411 657714
SGTC_2206 7254556 146.969 µM 0.314272836209508 0.386111623693277 no 1265 0.376656913690774 392 4398905
SGTC_3032 9089427 49.47 µM 0.314096710014091 0.386174967687877 no 1266 0.376723794106671 411 17173707
SGTC_782 0083-0095 30.5 µM 0.313579124497532 0.386361135485714 no 1267 0.376920358307251 393 3591729 An indicator and reagent.
SGTC_3027 9089541 49.47 µM 0.31296786450048 0.386581030289845 no 1268 0.377152538487055 398 9943819
SGTC_1570 verbenone 133 µM 0.312193422369399 0.386859680569574 no 1269 0.377446765332865 441 29025 A natural terpanoid with antifungal properties.
SGTC_475 α-linolenic acid 10 µM 0.311919907163981 0.386958107405657 no 1270 0.377550696518024 396 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2911 7942208 15.64 µM 0.311154965210498 0.387233417028749 no 1271 0.377841408670494 393 1243384
SGTC_2241 6772625 37.8075 µM 0.309927229597408 0.38767540887883 no 1272 0.378308147714963 416 2285411
SGTC_736 0958-0254 92.6 µM 0.309788067921348 0.387725517076421 no 1273 0.378361062986238 438 6812352
SGTC_1594 piperine 70.1 µM 0.309750407796107 0.387739077747679 no 1274 0.378375383382387 400 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2807 7945238 51.95 µM 0.309313600642739 0.387896373422983 no 1275 0.378541493051884 431 17148797
SGTC_225 nsc-122657 1.016 µM 0.308795475231351 0.388082975917858 no 1276 0.378738555647567 413 275685
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.308740660647235 0.388102718863323 no 1277 0.378759405542288 407 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1072 oxiconazole 14.9 nM 0.308351504441349 0.388242892240367 no 1278 0.378907439536664 392 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_114 0364-0001 490.298 µM 0.308278398673115 0.38826922643372 no 1279 0.37893525076078 372 4003655
SGTC_1642 st009582 77.7 µM 0.308056309167264 0.388349230767511 no 1280 0.379019742890114 423 6739311
SGTC_1569 carminic acid 40.6 µM 0.307690169344082 0.388481137357736 no 1281 0.379159050399453 419 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2653 dihydrofissinolide 100 µM 0.306376514655463 0.388954504145134 no 1282 0.379658993871228 407 6857746
SGTC_3145 9085516 49.47 µM 0.306202451268506 0.389017239123672 no 1283 0.379725253074179 388 25236195
SGTC_839 0122-0028 230 µM 0.30560198608471 0.38923367771638 no 1284 0.379953854052422 408 759448
SGTC_956 1185-0240 191 µM 0.30539175256866 0.389309464835526 no 1285 0.380033901230807 401 1416193
SGTC_2541 muurolladie-3-one 83.07 µM 0.302974979551762 0.390180989528817 no 1286 0.380954464701824 441 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_616 4092-0450 108 µM 0.302832439211328 0.390232409007608 no 1287 0.381008780286038 414 787165
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.302438977161162 0.390374355026325 no 1288 0.381158722787413 443 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_525 k781-2675 26.7 µM 0.30023049096577 0.391171362873736 no 1289 0.382000674405084 410 3651118 YDL195W SEC31
SGTC_1938 st074717 56.4 µM 0.300118235127075 0.391211886474756 no 1290 0.382043485174061 411 17250979
SGTC_214 4373-3496 70 µM 0.300116073394837 0.391212666857112 no 1291 0.382044309603415 433 3779166
SGTC_64 000l-0018 272.079 µM 0.299666476438183 0.391374980251423 no 1292 0.382215785995268 390 6811119
SGTC_3080 9117754 49.47 µM 0.299179030044502 0.391550979413249 no 1293 0.382401724274752 415 9550191
SGTC_3308 9128332 17.569 µM 0.298138809501641 0.39192663941443 no 1294 0.382798610987103 428 17332805 YDL196W YDL196W
SGTC_658 3253-0951 102 µM 0.297428615863243 0.392183173073184 no 1295 0.383069649666979 432 1184878
SGTC_460 trequinsin 123 µM 0.295529210573522 0.392869499609407 no 1296 0.383794820723782 409 5537 A vasodilator.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.293206097400538 0.393709380542338 no 1297 0.384682311877448 440 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1604 st002052 72.4 µM 0.291073373076742 0.394480865406837 no 1298 0.385497601934135 383 6254834 YHR062C RPP1
SGTC_2247 cerulenin 830 nM 0.290905748279791 0.39454151905429 no 1299 0.385561702432185 418 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_316 k060-0003 58.6 µM 0.289540881982921 0.395035479683067 no 1300 0.386083749818008 420 6152314
SGTC_55 0767-0285 6.563 µM 0.28895656263478 0.395247003129264 no 1301 0.386307309118279 435 3116166
SGTC_1021 4476-0760 85.3 µM 0.288356227058614 0.395464356596022 no 1302 0.386537035507426 407 746768
SGTC_3016 9080866 49.47 µM 0.288306429101283 0.395482387571592 no 1303 0.386556093145216 431 17066299
SGTC_3043 9092303 49.47 µM 0.288151815804339 0.395538371786978 no 1304 0.386615265271636 390 25236084
SGTC_695 3505-6186 243 µM 0.288004924293204 0.395591562003495 no 1305 0.38667148463195 416 1819379
SGTC_2561 acetosyringone 100 µM 0.287412509908302 0.395806098207985 no 1306 0.38689824179191 443 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1968 st069590 43.6 µM 0.28728966407171 0.395850589399691 no 1307 0.386945268060457 423 6384066
SGTC_568 1193-0097 7.48 µM 0.287025370010862 0.395946313626718 no 1308 0.387046447350739 405 3646150
SGTC_374 0880-0231 82.3 µM 0.286018766576006 0.396310951071619 no 1309 0.387431874033261 430 6833587
SGTC_510 ag-490 170 µM 0.283693149812334 0.397153741437287 no 1310 0.388322772403879 421 5328779
SGTC_274 sirtinol 40.1 µM 0.281504356665752 0.3979473867133 no 1311 0.389161793501033 371 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1346 1488-2224 62.4 µM 0.280270561751234 0.39839494088989 no 1312 0.389634967186574 419 3722427
SGTC_3159 9100096 49.47 µM 0.279762116960517 0.398579416136847 no 1313 0.389830008913222 394 25236875
SGTC_3213 9129884 49.47 µM 0.279753606728944 0.398582504033918 no 1314 0.389833273712847 400 17190742
SGTC_2146 5545642 200 µM 0.278067078115914 0.399194577994103 no 1315 0.390480433666955 426 825326
SGTC_1814 st052110 31.539 µM 0.277704092386352 0.399326345030254 no 1316 0.390619759426282 430 674163
SGTC_724 3910-0327 137 µM 0.277656088972054 0.399343771554037 no 1317 0.390638185753885 440 2885483
SGTC_1904 st060225 78 µM 0.277396067410083 0.399438169823024 no 1318 0.390738000473182 420 66595
SGTC_2623 humulene 100 µM 0.273971958464041 0.40068180538248 no 1319 0.392053085672694 398 6187145 An anti-inflammatory.
SGTC_352 k048-0007 5.11 µM 0.273827123231822 0.40073443179921 no 1320 0.392108739327673 448 6811911
SGTC_2362 9071156 126 µM 0.273633113992413 0.400804928596103 no 1321 0.392183291796732 403 653133
SGTC_1952 st077036 64.1 µM 0.272556733777055 0.401196109609243 no 1322 0.392596987232915 415 2937007
SGTC_3229 9132204 49.47 µM 0.271561841800018 0.401557764056263 no 1323 0.392979471479126 424 17682924
SGTC_1557 sumaresinolic acid 42.3 µM 0.271069585510855 0.401736735972381 no 1324 0.393168756673565 403 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_327 1273-0057 3.96 µM 0.271009239643843 0.401758677619813 no 1325 0.39319196294927 435 3108138
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.270158563264882 0.402068014925086 no 1326 0.39351913474037 426 5106787 A p450 inhibitor.
SGTC_1881 5652484 16 µM 0.269400877228297 0.402343589178451 no 1327 0.393810605588965 442 2255129
SGTC_1168 k815-0004 80.5 µM 0.268634371327939 0.402622420653745 no 1328 0.394105529855295 423 642433
SGTC_2762 leflunomide 42.06 µM 0.267264369743314 0.403120908778437 no 1329 0.394632809022382 417 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_729 4092-0585 94.1 µM 0.266693030497638 0.403328842584323 no 1330 0.394852760243542 395 2169061
SGTC_2689 tacrolimus 100 µM 0.266274773171408 0.403481080928421 no 1331 0.395013800034162 446 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1229 0139-0193 12.2 µM 0.264947586188639 0.403964250492169 no 1332 0.395524919668041 425 3090752
SGTC_207 4185-0010 4.486 µM 0.264866865085701 0.403993642179562 no 1333 0.395556012384278 427 3761753
SGTC_1978 st071761 42 µM 0.264802373833061 0.404017124740014 no 1334 0.395580854051554 404 5147680
SGTC_691 1548-0686 185 µM 0.263468047094906 0.404503057400397 no 1335 0.396094924245752 453 46495133
SGTC_653 0203-0016 55.2 µM 0.263303676169606 0.404562927910399 no 1336 0.39615826323119 435 295302
SGTC_527 4476-4215 268 µM 0.262635152748819 0.404806454073943 no 1337 0.396415901469473 405 4418754
SGTC_621 3584-0052 32.1 µM 0.262171355377518 0.404975425389683 no 1338 0.396594668147638 450 2273927
SGTC_390 dec-rvkr-cmk 16.7 µM 0.261158796553906 0.405344383780125 no 1339 0.396985025659266 412 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2140 5586273 200 µM 0.260865893642034 0.405451128084255 no 1340 0.397097963652609 437 854421
SGTC_935 2996-0153 430 µM 0.260574723983577 0.405557247699075 no 1341 0.397210241888517 432 23738523
SGTC_1020 4335-0961 93.3 µM 0.260083099658462 0.405736440719546 no 1342 0.397399836988256 434 669075
SGTC_2031 5180455 200 µM 0.259460520996758 0.405963393862032 no 1343 0.397639969460693 437 29949
SGTC_1828 st055811 49 µM 0.259409621107117 0.405981950168893 no 1344 0.397659603582165 454 5877589
SGTC_457 grayanotoxin iii 135 µM 0.258370830431816 0.40636070274614 no 1345 0.398060363225205 429 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3193 9111931 49.47 µM 0.256761960053711 0.406947484446675 no 1346 0.398681268618963 420 17087244
SGTC_2820 7989630 71.43 µM 0.256509359415026 0.407039631098456 no 1347 0.39877877718898 418 2984098
SGTC_106 0092-0003 11.579 µM 0.256470007779615 0.40705398671734 no 1348 0.398793968225062 441 1072148
SGTC_3059 1327-0034 3 µM 0.256428919114572 0.407068976144171 no 1349 0.398809829975796 401 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.254174848598729 0.407891484496316 no 1350 0.399680240286361 413 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1037 k284-1091 78.7 µM 0.253256173140291 0.408226825057499 no 1351 0.400035130529434 444 3334711
SGTC_2385 9074692 200 µM 0.252365363799722 0.408552057957844 no 1352 0.400379334773675 409 17046906
SGTC_676 falcarinol 140 µM 0.25202884428391 0.40867493703757 no 1353 0.400509384373734 446 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1387 3342-1166 1.8 µM 0.250733236523018 0.409148107998715 no 1354 0.401010181141191 417 3418228
SGTC_2654 protoveratrine a 100 µM 0.250351836347465 0.409287425018069 no 1355 0.401157636404959 461 5702278 A heart drug and vasodilator.
SGTC_1384 3089-0840 101 µM 0.248356708621707 0.410016387244686 no 1356 0.401929212951629 406 1069836
SGTC_1705 st027868 56.3335 µM 0.248037487584766 0.410133050354551 no 1357 0.402052700994394 463 292948
SGTC_1397 3532-0190 20.1 µM 0.247410525149551 0.410362204348336 no 1358 0.402295264726015 412 5322280
SGTC_3255 9139072 49.47 µM 0.245749439258962 0.410969476957323 no 1359 0.402938099245037 407 17646060
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.24555285689148 0.411041359209868 no 1360 0.403014193345503 426 688662
SGTC_776 4476-4378 112 µM 0.24513280768623 0.411194964290441 no 1361 0.403176800430118 451 2892008
SGTC_2849 9019321 12.99 µM 0.241647223918699 0.412470108034781 no 1362 0.4045267634231 421 16489627
SGTC_409 arachidonic acid 100 µM 0.24146305804729 0.412537507932602 no 1363 0.404598122449806 425 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_103 0844-0104 51.839 µM 0.240718001923263 0.412810205313009 no 1364 0.404886842828796 412 5375804
SGTC_3138 9097216 49.47 µM 0.238448644997651 0.413641069551036 no 1365 0.405766570995033 461 25237486
SGTC_139 0099-0334 718.624 µM 0.238382530865303 0.41366528128578 no 1366 0.405792207645766 425 97690
SGTC_1232 0279-0259 161 µM 0.234566068800573 0.415063465876487 no 1367 0.407272773989113 443 1560000
SGTC_2556 citropten 84.59 µM 0.233059192346125 0.41561581684122 no 1368 0.407857721090633 378 2775 A potential DNA crosslinker.
SGTC_1342 1486-1464 234 µM 0.23105903763662 0.416349238148779 no 1369 0.408634468648289 445 3253938
SGTC_2539 epi(13)torulosol 80 µM 0.229704413832125 0.416846120345199 no 1370 0.409160732435867 424 6708597
SGTC_1922 5578187 25 µM 0.229026337221657 0.417094891892883 no 1371 0.409424222981463 456 1350412
SGTC_1816 st051957 91.6 µM 0.228349870504672 0.417343105884599 no 1372 0.409687128723295 468 674121
SGTC_876 0720-0963 56.8 µM 0.227282299415543 0.41773489366318 no 1373 0.410102117997416 454 765861
SGTC_2197 6588183 93.1375 µM 0.225775844084067 0.418287886361772 no 1374 0.410687882815396 419 884136
SGTC_2440 5628896 157.78 µM 0.224944814967791 0.418593011439997 no 1375 0.41101110262999 443 5522048
SGTC_346 4513-0042 7.16 µM 0.224544478840601 0.418740018480251 no 1376 0.411166830629808 426 2827372
SGTC_611 3453-1652 23.7 µM 0.221977926728045 0.419682748327109 no 1377 0.412165533303463 438 1560575
SGTC_3101 9120531 49.47 µM 0.22129403386252 0.419934029603524 no 1378 0.412431747562696 472 24824904
SGTC_500 h-89 112 µM 0.220820340229796 0.420108096972951 no 1379 0.412616162642635 453 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2359 9039622 200 µM 0.219759238430118 0.420498074858096 no 1380 0.413029333294164 448 6463596
SGTC_3330 9141424 71.43 µM 0.215767304551009 0.42196589304936 no 1381 0.414584567591888 422 27261020
SGTC_2134 5324836 1.464 µM 0.215052962586289 0.422228668746788 no 1382 0.414863013126569 471 699272
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.214491624801852 0.422435185083438 no 1383 0.415081848717344 405 6708561
SGTC_1445 4239-0156 97.7 µM 0.213808107172136 0.422686680207451 no 1384 0.415348351268078 467 4008346
SGTC_1161 k007-0610 110 µM 0.213601627973579 0.422762658864496 no 1385 0.415428864879316 451 5843850
SGTC_2113 5491891 107.031 µM 0.213502301256171 0.422799209384025 no 1386 0.415467597177794 440 789979
SGTC_20 0481-0013 4.944 µM 0.213449215915681 0.42281874414663 no 1387 0.415488298060319 450 182045
SGTC_317 4495-0002 170 µM 0.212217580847079 0.423272024126691 no 1388 0.41596864578516 440 15991618
SGTC_2537 larixol 68.93 µM 0.21078648173105 0.42379884062166 no 1389 0.416526943785876 475 6708759
SGTC_2307 7538926 6.34 µM 0.210540563406414 0.42388938186613 no 1390 0.416622898022084 446 96582
SGTC_1917 st066507 28.5 µM 0.209180565592644 0.424390172953056 no 1391 0.417153641618879 437 3156428
SGTC_2775 cyproheptadine 69.59 µM 0.208972322984461 0.424466864788156 no 1392 0.417234922333086 468 2913 A selective serotonin reuptake inhibitor.
SGTC_364 0083-0097 67.7 µM 0.20824851149107 0.424733453171285 no 1393 0.417517466048393 422 5207356
SGTC_576 1073-0113 22.7 µM 0.208233857800655 0.424738850655762 no 1394 0.417523186635725 463 5439563
SGTC_1428 4049-0204 61.7 µM 0.207781359872423 0.424905528958725 no 1395 0.417699843823194 457 X1428
SGTC_161 4065-0411 162.148 µM 0.206688974689666 0.425307965983203 no 1396 0.418126384202104 451 1906281 YLR208W SEC13
SGTC_928 2764-0428 58.7 µM 0.206577187732537 0.425349152933166 no 1397 0.418170038762033 466 662578
SGTC_175 3793-3120 23.7 µM 0.205938496883783 0.425584488734949 no 1398 0.418419476873528 472 5322297
SGTC_2283 7944793 200 µM 0.204642993902448 0.426061918757099 no 1399 0.418925530961116 482 2970533
SGTC_404 fumagillin 50 µM 0.204184279535762 0.426230994185018 no 1400 0.419104747844696 434 12015870 A methionine aminopeptidase binder.
SGTC_1214 0358-0031 63.7 µM 0.204068208699722 0.426273778353843 no 1401 0.419150098669537 460 4301366
SGTC_1477 0139-0234 16 µM 0.20396986411742 0.426310029234567 no 1402 0.419188524390043 448 620880
SGTC_2568 diosmetin 100 µM 0.203271181404846 0.426567589174502 no 1403 0.419461539601058 474 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_962 1254-0300 21.5 µM 0.201895098158303 0.427074955148909 no 1404 0.419999367136392 439 7340576
SGTC_1787 fluconazole 80 µM 0.201129868418062 0.427357149883872 no 1405 0.420298513781704 449 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3019 9081971 49.47 µM 0.200133643381895 0.427724584722418 no 1406 0.420688030991382 448 16451803
SGTC_1856 st057054 55.7 µM 0.199758394272569 0.42786300305226 no 1407 0.420834770997196 462 1266018
SGTC_1522 st012842 45.6 µM 0.198748376433253 0.428235612907229 no 1408 0.421229789948825 483 3491067 YOR116C RPO31
SGTC_2046 4110841 106 µM 0.198631984167265 0.42827855577739 no 1409 0.421275316179676 474 44119630 YMR134W ERG29
SGTC_1822 st052468 42 µM 0.198347053627749 0.428383684345427 no 1410 0.421386769722586 459 2873678
SGTC_221 trifluoperazine 10.304 µM 0.196989674629751 0.42888457539468 no 1411 0.421917808961015 475 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.196889304042471 0.428921618045409 no 1412 0.421957081993778 432 16486 A toxic proline analog.
SGTC_377 3970-0964 33.1 µM 0.194498851116669 0.429804020078416 no 1413 0.422892647613715 446 16481235
SGTC_1172 0370-0043 85 µM 0.193689996715954 0.430102676935442 no 1414 0.423209312490715 437 376585
SGTC_2192 5915882 198.485 µM 0.193476455411504 0.430181530407896 no 1415 0.42329292176996 459 2876149
SGTC_878 0828-0289 13.7 µM 0.19307166722044 0.430331012429342 no 1416 0.423451420720818 442 745350 YLR208W SEC13
SGTC_169 k015-0017 16.025 µM 0.192126955248025 0.430679918764883 no 1417 0.423821380492146 458 1840002
SGTC_1423 4048-0112 5.59 µM 0.190957559418685 0.431111881532673 no 1418 0.42427942195166 469 X1423
SGTC_410 α-linolenic acid 100 µM 0.190049876659155 0.431447227028876 no 1419 0.424635023384928 480 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2787 5284540 71.43 µM 0.189002307680982 0.431834315225843 no 1420 0.425045504060655 462 736958
SGTC_1759 st043059 70 µM 0.188890820005439 0.431875515001889 no 1421 0.425089194317242 463 669426
SGTC_1374 2889-5571 141 µM 0.188387765868771 0.432061425635413 no 1422 0.425286344710904 432 2853281
SGTC_299 1273-0059 1.44 µM 0.186662571122467 0.432699109310437 no 1423 0.42596260207671 458 2848077
SGTC_2033 5192550 145 µM 0.186633748541021 0.432709764493805 no 1424 0.425973902066892 465 182073
SGTC_2662 daunorubicin 22.37 µM 0.185997183155408 0.432945103582007 no 1425 0.426223485151355 444 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2680 butyl paraben 22.24 µM 0.185186565570618 0.433244824422606 no 1426 0.426541352984057 473 7184 An antifungal and steroid mimetic.
SGTC_1294 1000-1494 117 µM 0.183374308052165 0.433915034073791 no 1427 0.427252166626912 450 712797 YDL207W GLE1
SGTC_2399 5884133 200 µM 0.182678292624348 0.434172485332267 no 1428 0.42752522455418 430 722445
SGTC_1459 k035-0031 35.7 µM 0.182374895046757 0.434284718728209 no 1429 0.427644263125226 446 3877128 YMR208W ERG12
SGTC_2100 5377183 190 µM 0.181935491240143 0.43444727319001 no 1430 0.427816675653423 480 2844202
SGTC_1632 st005650 90 µM 0.180949410231575 0.434812107484827 no 1431 0.42820364259077 443 2759605
SGTC_2358 9037157 4 µM 0.179961005950094 0.43517785706357 no 1432 0.428591590545055 474 2388925
SGTC_2233 sulbentine 40.3845 µM 0.179925644511119 0.435190943256404 no 1433 0.42860547116472 464 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2656 pseudo-anisatin 100 µM 0.179670247880497 0.435285459886799 no 1434 0.428705726026784 486 6708809 A neurotoxin.
SGTC_953 1188-0045 9.7 µM 0.179313594249084 0.435417455673842 no 1435 0.428845736590864 465 6144426
SGTC_1907 st060210 83.7 µM 0.176860257734637 0.436325617903044 no 1436 0.42980907808812 474 688793
SGTC_2914 7968218 45.32 µM 0.175773215187832 0.436728120796081 no 1437 0.430236056584059 471 2977111
SGTC_2552 juarezic acid 87.02 µM 0.175685678330982 0.436760536217696 no 1438 0.430270443666144 432 1549512
SGTC_2364 9055074 200 µM 0.174850578622351 0.43706979995211 no 1439 0.430598522231903 453 6470630
SGTC_993 3909-8757 62.7 µM 0.173590140179559 0.437536652793762 no 1440 0.431093790685313 440 4288324 YLR208W SEC13
SGTC_998 3996-0085 177 µM 0.172941416485619 0.437776967014772 no 1441 0.4313487382307 464 715391
SGTC_1054 3429-0080 167 µM 0.172865751483297 0.437804997973061 no 1442 0.431378476340298 471 1162877
SGTC_1100 amiodarone 5.07 µM 0.171544288970942 0.438294598950515 no 1443 0.431897904481433 468 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2162 5663267 200 µM 0.170791699456354 0.438573475127045 no 1444 0.432193778025951 471 6456493
SGTC_577 r071-0003 38.6 µM 0.169915427681207 0.438898220867393 no 1445 0.432538324007846 478 4568517 YMR134W ERG29
SGTC_2112 5488546 200 µM 0.167810190367016 0.439678588143562 no 1446 0.433366302717728 470 600757
SGTC_774 k060-0086 136 µM 0.166926206212815 0.440006332574331 no 1447 0.433714056433391 476 5911235
SGTC_2343 7990716 14.84 µM 0.166915638622164 0.440010250845036 no 1448 0.433718213966939 472 6456862
SGTC_1474 0330-0125 5.35 µM 0.164714028241881 0.440826695543579 no 1449 0.434584537430651 478 X1474
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.164198796342894 0.441017800481173 no 1450 0.434787324313394 489 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_315 k915-0449 187 µM 0.163663585251724 0.441216330455868 no 1451 0.43499799284743 474 20970215 YNL149C PGA2
SGTC_518 1021-0119 62.6 µM 0.162945758617876 0.441482622605234 no 1452 0.435280571045841 455 1097762
SGTC_1241 0364-0022 50.8 µM 0.162852547881961 0.441517202935445 no 1453 0.435317266625651 471 4563895
SGTC_174 3553-0389 74.3 µM 0.161827686533957 0.441897446459148 no 1454 0.435720774853838 455 738071
SGTC_1786 berberine 21.6 µM 0.16180740226141 0.44190497286093 no 1455 0.435728761850822 485 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_320 4092-0846 5.34 µM 0.160565093011555 0.442365966834186 no 1456 0.436217974923436 467 1359356
SGTC_236 1509-0011 5.31 µM 0.159286974950324 0.442840330136455 no 1457 0.436721391113014 486 3107280
SGTC_51 1013-0126 23.419 µM 0.158382954288882 0.443175899699484 no 1458 0.437077522374993 498 1627850
SGTC_2781 5567276 71.43 µM 0.15742193696193 0.443532670932646 no 1459 0.437456162901849 451 2853274
SGTC_336 4111-0029 111 µM 0.156363231536652 0.443925761199272 no 1460 0.437873358813487 485 3131175
SGTC_2148 5546263 113.568 µM 0.156322391531197 0.443940925928749 no 1461 0.437889453707123 458 792097
SGTC_35 0133-0054 64.071 µM 0.155808291161085 0.444131828925822 no 1462 0.43809206752245 460 99677
SGTC_1372 2752-0194 270 µM 0.150261700329433 0.446192282547706 no 1463 0.440279074286311 481 823334
SGTC_3117 9124945 49.47 µM 0.148864216776994 0.446711652743996 no 1464 0.440830388707431 477 17592065
SGTC_1468 k284-1086 134 µM 0.148604616581572 0.446808142403234 no 1465 0.440932814979032 459 15996457
SGTC_1297 1068-0111 14.1 µM 0.147417053213974 0.447249582694848 no 1466 0.441401423027913 489 767057
SGTC_1932 st074806 40.9 µM 0.145532835066059 0.447950116953156 no 1467 0.442145096536228 492 17251235
SGTC_1207 2099-0101 141 µM 0.145294057393719 0.448038903841534 no 1468 0.442239353226397 481 5837381
SGTC_2639 lactacystin 53 µM 0.145031563777998 0.448136512250005 no 1469 0.442342975479377 455 3870 A proteasome inhibitor.
SGTC_2067 5224629 34.075 µM 0.143631747203826 0.448657087763466 no 1470 0.442895634969718 451 2835000
SGTC_1176 0848-0131 83.3 µM 0.143293842009613 0.448782764058451 no 1471 0.443029059505245 500 6769040
SGTC_1380 2291-0730 164 µM 0.141266848085599 0.449536766655421 no 1472 0.443829569165141 449 2999191
SGTC_3110 9122132 49.47 µM 0.140935483096856 0.449660045435565 no 1473 0.443960455221476 455 918317
SGTC_2666 tannic acid 100 µM 0.140356198298459 0.449875570282367 no 1474 0.444189281947737 485 16134267 A thiamine antagonist.
SGTC_1750 st081859 2.357 µM 0.138982203388033 0.45038682869598 no 1475 0.444732106096062 491 5291695
SGTC_2511 berberine 10.47 µM 0.13878186410029 0.450461381100837 no 1476 0.44481126281912 464 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1990 st072050 59.8 µM 0.138684132599153 0.450497750629957 no 1477 0.444849878636849 500 17233948
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.138535874726579 0.450552923695967 no 1478 0.444908459509567 468 77254
SGTC_1534 6-azauridine 81.6 µM 0.138120780493516 0.450707403011006 no 1479 0.44507248136089 497 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_561 1550-0330 72.9 µM 0.138041422339709 0.450736937380564 no 1480 0.44510384030329 478 6812934
SGTC_166 k072-0058 166.424 µM 0.137954193423571 0.450769401291261 no 1481 0.445138309830072 507 5846229
SGTC_2564 betulinic acid 100 µM 0.137869829199914 0.450800799365122 no 1482 0.445171647734691 450 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_514 4466-0038 2.65 nM 0.137660341713158 0.450878766251861 no 1483 0.445254431822285 491 5722064
SGTC_3009 9080819 71.4286 µM 0.136660000704067 0.451251098458517 no 1484 0.445649773816935 466 17027216
SGTC_1687 st020778 55.3625 µM 0.136609328567179 0.451269960039645 no 1485 0.445669801253108 497 4259299
SGTC_1361 1608-0041 5.61 µM 0.135043361937555 0.451852910479366 no 1486 0.446288795225812 496 X1361
SGTC_266 formosanin C 406 nM 0.134922636902785 0.451897856192996 no 1487 0.446336520770419 484 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2780 5215298 71.43 µM 0.134772411389886 0.451953785742511 no 1488 0.446395909657513 487 2834131
SGTC_1772 st048439 82.2 µM 0.134538806700848 0.452040759581265 no 1489 0.44648826335298 501 2927068 YDL195W SEC31
SGTC_2840 9008771 71.43 µM 0.134165374720297 0.452179797583261 no 1490 0.446635902646543 496 2992978
SGTC_1987 st072290 61.9 µM 0.133785406080839 0.452321275365351 no 1491 0.446786133852409 493 54697379
SGTC_1708 st033234 31.827 µM 0.132924771696462 0.452641746916814 no 1492 0.447126437881134 455 674664
SGTC_824 1304-0008 100 µM 0.132641353935741 0.452747289005022 no 1493 0.447238512824875 477 768245
SGTC_1663 st014140 55.4 µM 0.131099813487741 0.453321402329853 no 1494 0.447848174352509 485 4207120
SGTC_314 1671-0008 2.74 µM 0.12791148004529 0.454509136279477 no 1495 0.449109512958217 490 3913060
SGTC_2772 vinpocetine 57.06 µM 0.127333733955083 0.454724405000788 no 1496 0.449338130885435 503 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3135 9127742 49.47 µM 0.126805116205304 0.454921380108753 no 1497 0.449547323141875 504 3643468
SGTC_1273 0849-0096 14.1 µM 0.126565367558241 0.455010719614546 no 1498 0.449642204567416 490 5286025
SGTC_840 0245-0196 390 µM 0.126215294218427 0.455141174401878 no 1499 0.449780752573343 473 3827528
SGTC_2295 7971645 200 µM 0.126124664347681 0.455174948401038 no 1500 0.449816622020984 480 2978226 YKL099C UTP11
SGTC_380 3970-0968 6 µM 0.125111758086944 0.455552438602086 no 1501 0.450217537416342 498 2891601
SGTC_743 1275-0778 158 µM 0.124568635201142 0.455754866348078 no 1502 0.450432530212367 489 2849257 YMR203W TOM40
SGTC_2995 9067767 71.4286 µM 0.123824136584513 0.456032367650473 no 1503 0.45072726032552 470 11673567
SGTC_2156 5649887 115 µM 0.123683830644135 0.456084667106283 no 1504 0.450782807312149 483 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3211 9128781 49.47 µM 0.123616686429335 0.45610969558093 no 1505 0.4508093899832 469 17194361
SGTC_1210 3013-0140 750 nM 0.123243194393843 0.456248920519639 no 1506 0.450957261041503 495 905973
SGTC_615 k087-0205 167 µM 0.122959436737726 0.456354699170932 no 1507 0.451069609474035 497 9642773
SGTC_883 0850-0245 24.6 µM 0.12079472037991 0.457161759374415 no 1508 0.451926816005071 495 6823229 YPR165W RHO1
SGTC_3125 9127534 49.47 µM 0.119111929192513 0.457789268114741 no 1509 0.452593339949949 499 1639235
SGTC_3126 9127922 49.47 µM 0.118914014700281 0.457863076893813 no 1510 0.452671739210961 506 45595682
SGTC_2381 9035592 200 µM 0.118804430704008 0.457903944970817 no 1511 0.452715149177276 476 4749657
SGTC_133 0724-0033 378.92 µM 0.118530088031199 0.458006259831086 no 1512 0.452823828163906 516 280309
SGTC_2224 6650123 117.647 µM 0.118295040632143 0.458093921910224 no 1513 0.452916943406039 504 2908370
SGTC_3065 9113888 49.47 µM 0.118272456984984 0.458102344699488 no 1514 0.452925890171013 484 16648368
SGTC_1261 0712-0010 12.7 µM 0.117364769579101 0.458440891015614 no 1515 0.453285500445006 493 2840123
SGTC_3250 9135583 49.47 µM 0.116726909315141 0.458678816128165 no 1516 0.453538232744345 454 7699353
SGTC_54 0159-0055 9 µM 0.116048087000318 0.458932036551852 no 1517 0.453807215649976 493 3319099
SGTC_1418 3966-3099 2.4 µM 0.115583497006726 0.45910535171408 no 1518 0.453991321357765 504 740335
SGTC_1097 itavastatin 7.23 µM 0.115262864482893 0.459224968119359 no 1519 0.454118385992135 507 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3123 9126162 49.47 µM 0.114690792938968 0.459438396496591 no 1520 0.454345105969956 502 25239884
SGTC_919 tnp00227 403.569 nM 0.11389098798638 0.459736807207945 no 1521 0.454662104813373 488 1269246 A methoxyflavone. YNL221C POP1
SGTC_1506 4226-2149 212 µM 0.11326103326461 0.459971862035907 no 1522 0.454911804674712 490 991114
SGTC_2947 9072639 7.68 µM 0.112763645644388 0.460157462026706 no 1523 0.455108970515157 466 16488146
SGTC_2975 9084847 53.72 µM 0.112375227981583 0.46030240596063 no 1524 0.455262948052864 466 27211724
SGTC_2657 nystatin 74.44 µM 0.111352975245742 0.460683900213597 no 1525 0.455668224196426 488 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2759 disulfiram 3.38 µM 0.108791201181448 0.461640086275935 no 1526 0.456684051417512 491 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2597 laccaic acid a 100 µM 0.108306159816066 0.461821153841114 no 1527 0.456876418267463 490 5491415 A textile dye.
SGTC_1704 st028805 70.8 µM 0.107930034740268 0.461961568040221 no 1528 0.457025596000756 493 2876101
SGTC_2659 sanguinarine 24.21 µM 0.107080341360378 0.462278791159723 no 1529 0.457362621404384 497 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_588 3970-1144 52.9 µM 0.106214769891163 0.462601966849468 no 1530 0.45770597627901 501 1888707
SGTC_3066 9117245 49.47 µM 0.104087753850079 0.463396228558207 no 1531 0.458549854539658 500 17176980
SGTC_483 fpl-64176 144 µM 0.102796007064951 0.463878658833001 no 1532 0.459062437189036 511 3423
SGTC_1160 4092-0570 10.5 µM 0.102571203240843 0.463962622042455 no 1533 0.459151649373944 500 4994975
SGTC_2504 purpurogallin 52.29 µM 0.101731263296128 0.464276349976857 no 1534 0.459484993175794 473 5281571 An antioxidant.
SGTC_1446 4239-0190 62 µM 0.101343505102759 0.464421189953073 no 1535 0.459638890933785 508 1340085
SGTC_3240 9133527 49.47 µM 0.101012627680934 0.464544786887036 no 1536 0.459770218005434 501 17617455
SGTC_620 0109-0052 432 µM 0.100484549554161 0.464742053839959 no 1537 0.459979824210509 505 493037
SGTC_296 1222-0039 74.9 µM 0.100454497978045 0.464753280058995 no 1538 0.459991752698805 484 5984176
SGTC_951 1171-0579 82.7 µM 0.0995517473427458 0.465090529200692 no 1539 0.460350101739275 496 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2893 9048488 25.97 µM 0.0991768562798714 0.465230588204111 no 1540 0.460498925131153 502 6467338
SGTC_2738 aclarubicin 5.55 µM 0.0979221889815542 0.465699362143387 no 1541 0.460997040200417 499 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0974196273539869 0.465887144666587 no 1542 0.461196579244638 511 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3262 9137218 49.47 µM 0.0946335491215685 0.466928301480089 no 1543 0.462302950531357 509 17650664
SGTC_2092 5303694 80.6725 µM 0.0939240263857706 0.467193486409671 no 1544 0.462584753953144 494 1963699
SGTC_872 0588-0139 234 µM 0.0934450124474243 0.467372526655384 no 1545 0.462775016084217 495 2047100
SGTC_2981 9013952 38.96 µM 0.0933765413674195 0.467398119517531 no 1546 0.46280221317868 502 2996344
SGTC_3156 9099931 49.47 µM 0.0923975465638643 0.467764059192584 no 1547 0.463191094324947 488 18111053
SGTC_2413 inermin 26.06 µM 0.0922100755330804 0.467834137337865 no 1548 0.463265566517364 503 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2093 5331342 194.4 µM 0.0920936403613571 0.467877662222486 no 1549 0.463311820618628 503 33839
SGTC_1654 st012436 41.8 µM 0.0919769989834771 0.467921264574512 no 1550 0.463358157132994 505 4323132
SGTC_817 1391-0715 46 µM 0.0917291521965444 0.468013914815839 no 1551 0.463456617463505 505 1353946
SGTC_936 3005-4620 401 µM 0.0892055954720169 0.46895737013572 no 1552 0.46445925928279 516 777207
SGTC_849 0386-0493 241 µM 0.0891041807702927 0.468995288651289 no 1553 0.464499557419701 499 726119
SGTC_991 3996-0057 64.7 µM 0.0888006396569213 0.469108783031642 no 1554 0.464620174664145 480 715343
SGTC_1712 st032288 53.4 µM 0.0885338082595305 0.469208553679401 no 1555 0.4647262073617 503 2883011
SGTC_1192 1488-0095 21.4 µM 0.0872667567431442 0.469682341865407 no 1556 0.465229738729748 501 915875
SGTC_367 0335-0881 7.1 µM 0.0865880439474566 0.469936150433041 no 1557 0.465499484876101 516 23828853
SGTC_769 0302-0231 76 µM 0.085491111240037 0.470346380531054 no 1558 0.465935480902088 516 571869 YER009W NTF2
SGTC_429 1112-0049 25.5 µM 0.0852441017883437 0.470438761303658 no 1559 0.466033664998575 481 2836170
SGTC_2769 toremifene 3.73 µM 0.0844649502834828 0.470730171962799 no 1560 0.466343384424408 508 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3147 9097027 49.47 µM 0.0842840596991023 0.470797829145465 no 1561 0.466415292910148 506 25236841
SGTC_2846 9008642 19.48 µM 0.0835901267450522 0.471057383616528 no 1562 0.466691158589132 516 2992898
SGTC_902 1120-0002 2.07 µM 0.0823839417607514 0.471508566922529 no 1563 0.467170702628683 495 3280475
SGTC_766 1391-0721 126 µM 0.0798745855874791 0.472447328523967 no 1564 0.468168501497741 509 1020919 YIL115C NUP159
SGTC_2215 7188065 200 µM 0.079103686309515 0.47273575644149 no 1565 0.468475075726407 509 940217
SGTC_2108 5365811 200 µM 0.0777084948950016 0.473257796231164 no 1566 0.469029968296835 506 780283
SGTC_2065 5221596 34.26 µM 0.0765404848545234 0.473694866760615 no 1567 0.469494553084284 497 788581
SGTC_1139 k015-0024 46.9 µM 0.0765260484477068 0.473700269077738 no 1568 0.469500295534944 520 2766652
SGTC_2990 9074105 71.4286 µM 0.0760423350276585 0.473881284589484 no 1569 0.469692708600104 519 6502001
SGTC_541 4513-1321 94 µM 0.0755496377453824 0.474065667591063 no 1570 0.469888702570313 505 747515
SGTC_2270 7924575 90.91 µM 0.075264807215214 0.474172262776057 no 1571 0.470002010903065 501 1262135
SGTC_2027 5150920 200 µM 0.0750211954432519 0.47426343369035 no 1572 0.470098923943752 521 786715
SGTC_2473 5854593 8.94 µM 0.0730747013036693 0.474991950811869 no 1573 0.470873336629148 516 2872951
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0730069558508917 0.475017307518469 no 1574 0.470900291157877 492 94937 An inhibitor of serotonin biosynthesis.
SGTC_2802 7925815 54.55 µM 0.072964807053148 0.475033083605481 no 1575 0.470917061368881 499 1262923
SGTC_836 0330-0104 1.35 µM 0.0716916830462099 0.475509625974551 no 1576 0.471423637549865 509 46494820
SGTC_864 0469-0573 172 µM 0.0713456052151605 0.475639172268012 no 1577 0.471561349983753 504 689425
SGTC_1336 1486-0901 104 µM 0.0704069122325823 0.475990563368805 no 1578 0.471934894868937 501 5006114
SGTC_3017 9080681 49.47 µM 0.0703349023411345 0.476017520385259 no 1579 0.471963551616288 515 16451914
SGTC_32 0928-0142 34.1 µM 0.0697018795529163 0.476254498174507 no 1580 0.472215472877829 515 2244242
SGTC_1092 toremifene 6.32 µM 0.0689471267894326 0.476537057647485 no 1581 0.472515852994996 521 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1962 st076595 64.5 µM 0.0680123187540904 0.476887041391867 no 1582 0.472887914022317 506 279619
SGTC_3041 9091929 49.47 µM 0.0670462694968915 0.477248740299052 no 1583 0.473272434155326 506 25236887
SGTC_2116 5511452 16.8835 µM 0.0667123826020151 0.477373755404858 no 1584 0.473405338191807 514 870744
SGTC_600 1495-0418 41.6 µM 0.0652347718096485 0.477927034199419 no 1585 0.473993538089752 515 5377768
SGTC_757 1066-0008 322 µM 0.0647215057787709 0.478119232309716 no 1586 0.474197869792267 495 6842497
SGTC_759 3486-0358 89.3 µM 0.0641675847763906 0.478326659829393 no 1587 0.474418393892264 520 875103
SGTC_1757 st041620 31.8375 µM 0.0639439629958188 0.47841040143565 no 1588 0.474507423237649 500 5289815
SGTC_387 norethindrone acetate 66.7 µM 0.0633347149577563 0.478638556708284 no 1589 0.474749986351765 516 541197
SGTC_2390 9097792 176.6 µM 0.061917996463274 0.47916912584596 no 1590 0.475314067945175 509 4497149
SGTC_2010 4012422 159 µM 0.0613524321398435 0.479380943265395 no 1591 0.475539267301698 504 952393
SGTC_1283 0922-0125 16.4 µM 0.0612158802921212 0.479432086086219 no 1592 0.47559364140354 523 3360884
SGTC_1281 0884-0031 11.8 µM 0.0605694091523521 0.479674213775581 no 1593 0.475851068368549 516 1548255
SGTC_1179 1021-1431 9.29 µM 0.0593146355633484 0.480144194875291 no 1594 0.476350752072688 523 2840958
SGTC_657 3534-0529 86.7 µM 0.0588091164032783 0.48033354719112 no 1595 0.476552073595202 514 1049549
SGTC_27 0485-0001 32.618 µM 0.0587698496565928 0.48034825552303 no 1596 0.476567711713046 525 2054479
SGTC_715 0868-0130 184 µM 0.0584199150815791 0.480479333359086 no 1597 0.476707075960381 510 2876258
SGTC_1884 5633444 25 µM 0.058273093901561 0.480534329990416 no 1598 0.476765549520742 515 5724239
SGTC_1846 st056244 14.8 µM 0.0568940079212061 0.481050929281996 no 1599 0.477314813784684 503 5393182
SGTC_2824 7998404 51.95 µM 0.0558098047322889 0.481457089218348 no 1600 0.47774666203641 520 837851
SGTC_1278 0874-0585 172 µM 0.0545066665314999 0.481945291162016 no 1601 0.478265748681685 521 766306
SGTC_2480 5767542 37.17 µM 0.0536501329112439 0.48226619392953 no 1602 0.478606956854924 516 2867358
SGTC_2090 5301565 104.445 µM 0.0535240184846603 0.482313444035103 no 1603 0.478657197045784 511 2056344
SGTC_2136 5328288 199.296 µM 0.0534214608702854 0.482351868514682 no 1604 0.478698053161905 524 262395
SGTC_3143 9086658 49.47 µM 0.0532476655543056 0.48241698345497 no 1605 0.478767288918264 504 25236626
SGTC_2750 bromebric acid 70.15 µM 0.0524303376985645 0.482723213472293 no 1606 0.479092900682875 512 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_924 2046-0044 21.3 µM 0.0517343303819785 0.482983996100285 no 1607 0.479370191083441 525 3623589
SGTC_40 0327-0103 19.753 µM 0.0514738613942872 0.483081591474055 no 1608 0.479473964909091 520 409036
SGTC_2648 atorvastatin 78.68 µM 0.0511745451216631 0.483193743825554 no 1609 0.479593217655295 523 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2888 9058547 12.99 µM 0.0502578297091429 0.483537240867113 no 1610 0.479958464146458 516 16476514
SGTC_1635 st007035 42.4 µM 0.0495079421122729 0.483818235936245 no 1611 0.480257254036273 524 3716403
SGTC_1678 st019265 80.2 µM 0.0489099305213772 0.484042326364704 no 1612 0.48049553746181 523 5367020
SGTC_2808 7946468 45.46 µM 0.0486474681900506 0.484140679392386 no 1613 0.480600120288274 521 2970879
SGTC_286 k060-0067 22.9 µM 0.0470545781730199 0.484737606696187 no 1614 0.48123486428778 510 5985051
SGTC_1137 ixabepilone 100 µM 0.0470355201343263 0.484744748807456 no 1615 0.481242458936167 532 154225 A novel microtubule stabilizer.
SGTC_213 1246-0773 967 nM 0.0468574636638454 0.484811476745493 no 1616 0.48131341495477 524 6251622
SGTC_1018 4259-0013 28.1 µM 0.046450125066467 0.484964131399845 no 1617 0.481475742786944 507 6801262
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0458412865303748 0.485192304491242 no 1618 0.481718375745126 528 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1913 st060213 96.1 µM 0.0458197310713138 0.485200382872967 no 1619 0.481726966102634 508 688959
SGTC_1149 3909-7961 23.3 µM 0.0456921834662445 0.485248184263608 no 1620 0.481777796997191 535 735261
SGTC_3031 9088762 49.47 µM 0.0447763478319832 0.485591420858873 no 1621 0.482142788937692 519 205253
SGTC_1010 4112-3296 15.2 µM 0.0447370658647819 0.485606143182945 no 1622 0.482158444487102 519 704384
SGTC_202 3594-0513 34.79 µM 0.0445377804301293 0.485680832838711 no 1623 0.482237868706933 533 708429
SGTC_2293 7624732 200 µM 0.04451393498253 0.485689769844027 no 1624 0.482247372238882 530 894453
SGTC_1290 0986-0249 10.2 µM 0.0431958884987719 0.486183769880493 no 1625 0.48277269126706 533 53329
SGTC_3006 9075424 71.4286 µM 0.0426807822510618 0.486376836026738 no 1626 0.482977999575109 529 7465181
SGTC_2352 9027995 87.8 µM 0.041992844444971 0.486634685864112 no 1627 0.483252201196411 518 2997347
SGTC_508 roscovitine 141 µM 0.0419709524509885 0.486642891417782 no 1628 0.483260927145369 532 160355 A CDKinase inhibitor.
SGTC_1806 st050005 60.3 µM 0.0416521460845932 0.48676238700788 no 1629 0.483388001359158 524 5194765
SGTC_1655 st012546 55.1 µM 0.0414049726557423 0.486855033826763 no 1630 0.483486524296252 529 720985 YLR208W SEC13
SGTC_2338 7999974 200 µM 0.0395045701366591 0.487567375820421 no 1631 0.484244054960306 530 315925
SGTC_1461 k072-0203 53.8 µM 0.038663488409624 0.487882657529748 no 1632 0.484579341829166 523 5418714
SGTC_2932 9016711 44.54 µM 0.036811900402862 0.48857675659805 no 1633 0.485317492665702 527 7117328
SGTC_2288 7946289 167.31 µM 0.03603779516521 0.4888669534111 no 1634 0.485626111166046 530 1246052
SGTC_2445 5742597 35.57 µM 0.035933825681073 0.488905929976106 no 1635 0.485667562141368 534 1774255
SGTC_1523 st012844 44.7 µM 0.0357971304158776 0.488957175095673 no 1636 0.485722060599299 510 4274103
SGTC_1785 bathophenanthroline 24 µM 0.0349554552903079 0.489272711168621 no 1637 0.486057630337882 533 72812 An iron chelator.
SGTC_802 4112-3352 742 µM 0.0339888003284413 0.489635109275934 no 1638 0.48644304079275 519 704594
SGTC_1148 3909-7663 27.7 µM 0.0304271311122427 0.490970447516475 no 1639 0.48786320368542 523 4084526
SGTC_281 1672-3440 14.9 µM 0.0301009212270974 0.491092755157513 no 1640 0.487993283016107 536 6833000
SGTC_1668 st014914 51.6 µM 0.0299298687016836 0.491156889143799 no 1641 0.488061492367941 537 2839556
SGTC_983 1491-0821 12.2 µM 0.0290765314302322 0.491476840569602 no 1642 0.488401776544135 528 46495113
SGTC_2089 5281248 129.67 µM 0.0286539861524241 0.491635272307975 no 1643 0.488570277507192 525 2737878
SGTC_445 e6 berbamine 66 µM 0.028390133970253 0.491734203346992 no 1644 0.488675496491188 538 6610268 A calcium/calmodulin antagonist.
SGTC_1945 st075991 56.6 µM 0.0280119307589335 0.491876011043692 no 1645 0.488826317756 528 1084980
SGTC_335 4077-0256 27.6 µM 0.0277302077009758 0.491981644072453 no 1646 0.488938665350728 529 3121989
SGTC_1868 st057644 42.7 µM 0.0274317450172394 0.4920935542947 no 1647 0.489057689453912 529 688665
SGTC_1316 1272-0050 65.9 µM 0.0269896027323261 0.492259339113628 no 1648 0.489234013414835 534 7340392
SGTC_1752 st044819 83.042 µM 0.0253696595088133 0.492866761108938 no 1649 0.489880055759973 531 441209 YML126C ERG13
SGTC_2347 9049783 174.81 µM 0.0240155225737111 0.493374527803185 no 1650 0.490420113527384 539 6467988 YPL169C MEX67
SGTC_1480 1070-0044 41.2 µM 0.0239262301973799 0.493408010545336 no 1651 0.490455725798681 532 3124987
SGTC_1732 st034308 51.822 µM 0.0237630587787629 0.493469196476975 no 1652 0.490520803273364 538 830119
SGTC_1845 st056753 3.01 µM 0.023536434753506 0.493554176087834 no 1653 0.490611187898529 537 5375839
SGTC_2522 biochanin a 4.94 µM 0.022911978481382 0.493788336571495 no 1654 0.490860242729062 536 5280373 A possible chelator.
SGTC_1033 k072-0102 21.3 µM 0.0229117814779548 0.493788410444772 no 1655 0.490860321301432 537 5965931
SGTC_2581 avocatin a 64 µM 0.0221090518732546 0.494089423530485 no 1656 0.491180482945635 534 6710728 A skin care supplement.
SGTC_1999 st074831 12.5 µM 0.0212106698694521 0.494426308995638 no 1657 0.491538801436514 532 17112523
SGTC_2525 harmine 47.85 µM 0.0206806365714784 0.494625068768448 no 1658 0.491750207747406 539 5280953 A monoamine oxidase inhibitor
SGTC_704 1310-0270 142 µM 0.0202917231844414 0.494770910148754 no 1659 0.491905329185557 541 5718033
SGTC_2408 sulbentine 18.36 µM 0.0197671442380419 0.494967626819751 no 1660 0.492114563929866 514 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2228 7354201 200 µM 0.0195347640782541 0.495054769581413 no 1661 0.492207252302524 542 753451
SGTC_2386 9075165 157.42 µM 0.0189041945455709 0.495291234880586 no 1662 0.492458766688142 537 16452277
SGTC_2624 nerol 100 µM 0.0170787563928408 0.495975788211555 no 1663 0.493186893192113 539 637566 A natural product oil.
SGTC_1417 3966-0327 90.4 µM 0.0170036763180315 0.49600394408391 no 1664 0.493216841459513 540 651118
SGTC_447 ml7 120 µM 0.0162516605062803 0.49628595954494 no 1665 0.493516810884741 540 4216 Selective myosin light chain kinase inhibitor.
SGTC_115 0527-0192 112.043 µM 0.0149322137421143 0.49678077320476 no 1666 0.49404312996732 543 4233931
SGTC_2021 4019055 173 µM 0.0145689725408903 0.496916995372099 no 1667 0.494188026475528 542 44827708 YER133W GLC7
SGTC_3343 9148379 18.9835 µM 0.01339748111372 0.497356328688851 no 1668 0.49465533822112 543 1955036
SGTC_1111 tnp00062 510.699 nM 0.0123757466769015 0.497739502698303 no 1669 0.495062917425894 543 676306
SGTC_26 0302-0163 425.158 µM 0.0119197517009764 0.497910512038983 no 1670 0.495244819677911 541 3100915
SGTC_2969 9091408 28.7 µM 0.0118538041246489 0.497935244035983 no 1671 0.495271127095768 532 4286311
SGTC_2858 9025781 8.96 µM 0.0117963090189747 0.497956806150733 no 1672 0.495294062720712 539 4894980 YPL153C RAD53
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0114870693095755 0.498072778942105 no 1673 0.495417423155342 544 3256 An antibiotic and ribosome inhibitor.
SGTC_3091 9116372 49.47 µM 0.00857741607155952 0.499163979871407 no 1674 0.496578148031298 541 17169793
SGTC_2855 9016525 58.44 µM 0.00831796124176506 0.499261283076364 no 1675 0.496681651839207 542 43811474
SGTC_2107 5363541 170.161 µM 0.00806688386902607 0.499355444530016 no 1676 0.496781813857299 544 244052
SGTC_1443 4112-3303 14 µM 0.00666283450012484 0.499882005156122 no 1677 0.497341933277351 539 704433
SGTC_1052 3253-3998 198 µM 0.00648707301244953 0.499947921019069 no 1678 0.497412050450361 540 5450317
SGTC_401 neomycin 50 µM 0.00620934080768914 0.499947921019069 no 1679 0.497522847336548 542 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2506 ethyl hematommate 54.16 µM 0.00520234194751257 0.499570266125857 no 1680 0.49792457520171 538 3940691 An allergen.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.00504256944936616 0.49951034665499 no 1681 0.497988314370149 547 688798
SGTC_81 0411-0046 9.971 µM 0.00492758671399732 0.49946722469306 no 1682 0.498034185274806 546 12925265
SGTC_1780 st038448 24.544 µM 0.00466136051164745 0.499367381935961 no 1683 0.498140392942057 540 728868 YDL195W SEC31
SGTC_1415 3966-0071 78.1 µM 0.00422170549207542 0.49920249829546 no 1684 0.498315788186704 546 2893185
SGTC_57 miconazole 162.5 nM 0.00158885790689773 0.498215106382979 no 1685 0.499366137670083 548 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2063 5246145 200 µM 0.0014092036847455 0.498147731325614 no 1686 0.499437809254529 547 711240
SGTC_918 glabranin 770.725 nM 0.000491305487618581 0.497803496230906 no 1687 0.499803997476281 547 124049 Also referred to as licorice root.
SGTC_277 nystatin 15.5 µM -0.000509429051472479 0.497428197280122 no 1688 0.499796767221293 549 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2402 5553605 200 µM -0.000772636408937305 0.49732948870509 no 1689 0.499691762699765 548 6758546
SGTC_2160 5660466 132.927 µM -0.00145668711323671 0.497072955355446 no 1690 0.499418866126736 550 2859134
SGTC_149 3970-0822 46.1 µM -0.00188951818842481 0.496910635249992 no 1691 0.499246191753601 550 3114250 YBL034C STU1
SGTC_1972 st070201 17.4 µM -0.00221195830474789 0.496789714240751 no 1692 0.499117557029348 549 2829099
SGTC_467 ro 31-8220 72.8 µM -0.00300416164642201 0.496492624606132 no 1693 0.498801514704801 551 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2877 9040724 71.43 µM -0.00526205845710886 0.495645886393009 no 1694 0.49790075208729 556 6463895
SGTC_442 cape 100 µM -0.0057954632158978 0.495445855974027 no 1695 0.497687957631254 549 5281787
SGTC_791 1348-1292 225 µM -0.00618008280102252 0.495301621716525 no 1696 0.497534519368491 551 5437054
SGTC_486 niguldipine 82 µM -0.00741814737080708 0.49483734560996 no 1697 0.497040614513521 553 1236 A calcium channel blocker.
SGTC_1324 1418-0026 34.4 µM -0.00802394819429151 0.494610171883879 no 1698 0.496798942158932 570 1372513
SGTC_230 MPP+ 141.667 µM -0.00851659469576355 0.494425432018224 no 1699 0.496602411363402 558 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2821 7996764 71.43 µM -0.00914386662775897 0.494190210054547 no 1700 0.496352175828516 553 2987135
SGTC_1159 4092-0538 61.2 µM -0.00955828005584171 0.494034809432501 no 1701 0.496186856019824 554 717301
SGTC_97 0535-0701 19.132 µM -0.00975192243904191 0.493962195909974 no 1702 0.496109607486684 551 2832013 YGL099W LSG1
SGTC_1356 1502-0781 85.8 µM -0.0108947283388302 0.493533661845686 no 1703 0.495653718212719 557 567702
SGTC_2764 methyldopa 94.69 µM -0.0115283596926175 0.493296063334446 no 1704 0.495400951766442 555 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2170 morpholine 200 µM -0.0130855945616037 0.492712143092564 no 1705 0.49477975204521 561 121171 Reacts with secondary amines.
SGTC_1539 benzyladenosine 56 µM -0.0130961674872795 0.492708178588216 no 1706 0.494775534419535 553 92208 A nucleotide analog.
SGTC_1859 st055998 20 µM -0.0131952479944536 0.492671026645334 no 1707 0.494736010431287 563 676301
SGTC_520 3584-0023 682 µM -0.0139419581935276 0.492391036861265 no 1708 0.494438143589534 553 1340790
SGTC_1924 st058459 75.1 µM -0.0144377746669377 0.49220512536919 no 1709 0.494240361349955 558 688683
SGTC_1359 1582-0056 520 nM -0.0150964574849165 0.491958148089863 no 1710 0.493977613579204 563 3661189
SGTC_484 loperamide 105 µM -0.0152707474904411 0.491892797464325 no 1711 0.49390808994155 554 3955 An opioid-receptor agonist.
SGTC_172 1112-0046 2.638 µM -0.0155994756239637 0.491769540335371 no 1712 0.493776962011985 561 2802135 YIL048W NEO1
SGTC_1852 st056254 31.4 µM -0.0158457943385957 0.491677183261609 no 1713 0.493678707207619 560 442583
SGTC_917 harmaline 728.087 nM -0.0164563174093668 0.491448269888219 no 1714 0.493435175510807 557 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1562 morin hydrate 59.1 µM -0.0179407717039841 0.490891691125484 no 1715 0.492843051562347 558 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_594 1487-1584 10.8 µM -0.0191913683211108 0.490422808280993 no 1716 0.492344221709024 559 5013332
SGTC_843 0310-0051 143 µM -0.0194723305180524 0.490317469673617 no 1717 0.492232154952611 555 2065037
SGTC_418 lividomycin a 100 µM -0.0205120686017817 0.489927656038489 no 1718 0.491817442375256 560 72394 An antibiotic.
SGTC_464 bw-b 70c 158 µM -0.0227731883780254 0.489079961527393 no 1719 0.490915597525851 582 5353454
SGTC_408 cantharidin 100 µM -0.0228942273592658 0.489034585332328 no 1720 0.490867322545089 557 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1679 SEC14.276 6.7 µM -0.0230855833224227 0.488962848356804 no 1721 0.490791002732435 575 1005053 YMR079W SEC14
SGTC_2348 9022543 33.42 µM -0.0232917838376857 0.488885546742694 no 1722 0.490708762742614 564 3162678 YDL140C RPO21
SGTC_2001 4023502 57.655 µM -0.0235074038954506 0.488804714323877 no 1723 0.490622766331739 558 108941 YCR052W RSC6
SGTC_180 1486-1293 102.781 µM -0.0241070072464502 0.4885799353018 no 1724 0.490383626986802 571 4140536
SGTC_723 4182-0001 115 µM -0.0244625645872952 0.48844664584184 no 1725 0.490241821952162 569 744821 YLR208W SEC13
SGTC_2259 7964009 200 µM -0.0255218983558082 0.488049536095459 no 1726 0.489819340906487 570 313134
SGTC_38 0929-0051 58.268 µM -0.0263148556285223 0.487752289958151 no 1727 0.489503102968329 563 1379719
SGTC_1840 st055363 71 µM -0.0270217536594018 0.487487309521006 no 1728 0.489221191726995 573 676033
SGTC_3148 9097893 49.47 µM -0.0276041891071366 0.487268987977516 no 1729 0.488988920257803 559 17174100
SGTC_828 2074-0507 139 µM -0.0277903835322575 0.487199195200438 no 1730 0.488914667915776 557 X828
SGTC_2743 auranofin 4.32 µM -0.0278605028043157 0.48717291192251 no 1731 0.488886705200723 563 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1692 fluoroquinolonic acid 71 µM -0.0282949210963288 0.487010077241182 no 1732 0.488713465678855 582 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1268 0828-0275 2.46 µM -0.0285810865890974 0.486902813908968 no 1733 0.488599348318816 567 745337
SGTC_12 0849-0099 9.267 µM -0.0303272534116777 0.486248319499122 no 1734 0.487903030743105 559 6071388
SGTC_1714 st033236 13.627 µM -0.030436683185417 0.486207304486908 no 1735 0.487859394723715 573 2916566
SGTC_2488 5268135 45.7 µM -0.031706363705373 0.485731430502318 no 1736 0.487353109968358 569 1270356 YLR208W SEC13
SGTC_1720 st037298 9.481 µM -0.0330343442930238 0.485233727507472 no 1737 0.486823599896834 570 597396
SGTC_2024 5144227 134 µM -0.0336894625659345 0.484988209506736 no 1738 0.48656239092919 566 3475211
SGTC_463 ikarugamyin 104 µM -0.0339286051868377 0.484898587685831 no 1739 0.48646704133718 567 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1989 st071868 50.2 µM -0.0346007940928579 0.484646680213317 no 1740 0.486199034142938 561 16414057
SGTC_179 1273-0063 6.77 µM -0.0346139583607799 0.484641746873108 no 1741 0.486193785503885 568 3108139
SGTC_788 1182-0090 188 µM -0.0356597881995997 0.484249827268873 no 1742 0.485776817255997 560 5715185
SGTC_1637 st007924 17.4 µM -0.0364166323646438 0.483966213097202 no 1743 0.485475076133251 563 683336
SGTC_129 0088-0017 176.636 µM -0.0375178091888775 0.483553580783751 no 1744 0.485036070231872 565 182446
SGTC_131 0141-0277 33.849 µM -0.0391480011125126 0.482942748721031 no 1745 0.484386195462483 577 1547771
SGTC_3131 9127911 49.47 µM -0.0396683913004905 0.482747767150544 no 1746 0.484178750960358 579 45595681
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.0398671336747382 0.482673302766213 no 1747 0.484099526894705 564 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1954 st077032 68.9 µM -0.0406541842630167 0.482378418230737 no 1748 0.483785793517839 607 698907
SGTC_530 4358-1714 28 µM -0.041681508092078 0.48199352495949 no 1749 0.483376297776784 569 1564641
SGTC_2505 galangin 7.89 µM -0.0416862721455196 0.481991740116012 no 1750 0.483374398844898 580 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1743 st037606 46.3785 µM -0.0421668851872051 0.481811681223502 no 1751 0.483182830431033 575 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3069 9117009 49.47 µM -0.0421699616160885 0.48181052866915 no 1752 0.483181604204187 567 41904981
SGTC_2137 5261020 140 µM -0.04365303646499 0.481254926890533 no 1753 0.482590487486902 576 763655
SGTC_1765 st044815 90.4 µM -0.0441920920822916 0.481052990377341 no 1754 0.48237564275059 562 645695
SGTC_1269 0831-0796 3.05 µM -0.0479784648440407 0.479634710973132 no 1755 0.480866702701439 565 927758
SGTC_353 1988-1175 58.3 µM -0.0480934327830223 0.479591650834996 no 1756 0.480820890015512 575 2788357
SGTC_1882 5615643 20 µM -0.0483134406648539 0.479509249658808 no 1757 0.480733221480838 571 2253075
SGTC_2207 7258803 200 µM -0.0484849768466354 0.47944500355367 no 1758 0.480664868550096 571 3666799
SGTC_2186 6124449 200 µM -0.0488496832064221 0.479308410456435 no 1759 0.480519543967288 570 3834182 YLR033W RSC58
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0489902736170521 0.479255755922808 no 1760 0.48046352358143 565 6312947
SGTC_1391 3442-0225 151 µM -0.0499163110613024 0.478908941429367 no 1761 0.480094539579656 576 5227075
SGTC_2334 9017922 200 µM -0.0501023610359155 0.478839264925473 no 1762 0.480020409134268 570 3163164
SGTC_891 0929-0073 133 µM -0.0518414667880033 0.4781879940127 no 1763 0.479327507118631 601 5603632
SGTC_258 haloperidol 50.781 µM -0.0520872210550449 0.47809596711465 no 1764 0.479229597632597 559 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2721 ifenprodil 61.44 µM -0.0525664545964451 0.47791651326373 no 1765 0.479038672677192 579 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1237 0330-0133 46.1 µM -0.0542081037556412 0.477301815279258 no 1766 0.478384682158155 583 X1237 YHR072W ERG7
SGTC_2600 tangeritin 87.95 µM -0.0553597938330002 0.476870609380706 no 1767 0.477925913281675 583 68077 A bioactive flavone.
SGTC_1618 st003135 44.5 µM -0.0567599747553114 0.476346402200438 no 1768 0.477368199013223 570 1270615
SGTC_2205 7238770 200 µM -0.0568793486452787 0.476301712249513 no 1769 0.477320652534632 588 279867
SGTC_1263 0774-1208 64.8 µM -0.0569279204896241 0.476283528514697 no 1770 0.477301306519083 579 906585
SGTC_1314 1222-0010 41.1 µM -0.0573798385583964 0.476114347311086 no 1771 0.47712131151868 575 3526027
SGTC_2823 7987624 58.44 µM -0.0579371184099429 0.475905728532925 no 1772 0.476899358275351 578 2239440
SGTC_3265 9137266 49.47 µM -0.0592418750541361 0.475417316321335 no 1773 0.476379728361343 596 17224265
SGTC_2939 9044578 71.43 µM -0.0596030479292292 0.475282124239626 no 1774 0.476235895395195 578 2653634
SGTC_3084 9116877 49.47 µM -0.0597902259117047 0.475212062009479 no 1775 0.476161355121692 575 27241325
SGTC_3083 9117465 49.47 µM -0.0601925462028926 0.475061472873171 no 1776 0.476001141110328 604 16420915
SGTC_1496 4469-0713 57.4 µM -0.0604045628216526 0.47498211614156 no 1777 0.475916712344653 590 746691
SGTC_2610 ononetin 44.17 µM -0.0622205361017274 0.474302447650171 no 1778 0.475193604364621 586 259632
SGTC_193 1273-0060 1.558 µM -0.0630190271272686 0.474003618134519 no 1779 0.474875676489184 600 2847393 YHR072W ERG7
SGTC_43 0570-0105 72.5 µM -0.0640114856439024 0.473632218089213 no 1780 0.474480540671962 571 1114046 YDL195W SEC31
SGTC_885 0865-0106 16.8 µM -0.065402662373619 0.47311164747362 no 1781 0.473926702176445 578 2793380
SGTC_2563 tomatine 8.54 µM -0.0674765286638956 0.47233570372695 no 1782 0.473101173421868 583 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_618 k072-0232 33.2 µM -0.0692204344866307 0.471683296883232 no 1783 0.47240707887529 580 5872756 YGL099W LSG1
SGTC_1487 3970-0795 2.82 µM -0.0696984355922181 0.471504486661986 no 1784 0.472216843486033 575 3765103
SGTC_804 1595-0054 20.9 µM -0.0706945583049111 0.471131876477467 no 1785 0.471820425923293 599 761523 Stimulates phospholipase C.
SGTC_2862 9027634 71.43 µM -0.0710707309197691 0.470991171707448 no 1786 0.471670731295187 575 5012562
SGTC_3348 9149464 3.537 µM -0.0719332364241456 0.470668571175453 no 1787 0.471327519855358 577 1951442
SGTC_2513 baicalein 25.65 µM -0.073016842537625 0.470263300305523 no 1788 0.470896357439321 605 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2461 5755302 26.15 µM -0.0731832945941647 0.470201049619424 no 1789 0.470830129860488 596 2788904
SGTC_144 4161-2749 112.381 µM -0.073253263992767 0.470174882283397 no 1790 0.470802290830513 577 797501 YMR168C CEP3
SGTC_3103 9120822 49.47 µM -0.0733723048735049 0.470130363364026 no 1791 0.470754927843746 568 17141819
SGTC_2997 9067075 71.4286 µM -0.0739365237286912 0.469919361833274 no 1792 0.470530446818271 578 27209819
SGTC_292 k038-0015 474 µM -0.0742258549694959 0.469811163591132 no 1793 0.470415336651037 593 46368540
SGTC_2683 piperine 63.03 µM -0.0742976293556002 0.469784323203497 no 1794 0.470386781660054 597 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1645 Cervolide 78 µM -0.0748066785150461 0.469593965692776 no 1795 0.470184264011408 584 23173 A fragrance.
SGTC_1404 3909-7820 48.3 µM -0.075959558243687 0.469162875299199 no 1796 0.469725636523387 584 23741373
SGTC_2269 7935389 174.42 µM -0.0762109250208618 0.469068887794274 no 1797 0.469625645529746 573 97605
SGTC_3058 9093861 49.47 µM -0.0762810707053979 0.469042660220855 no 1798 0.469597742674351 585 17217477
SGTC_246 cycloheximide 667 µM -0.0767597152883246 0.468863697907214 no 1799 0.46940734934326 576 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2576 guaiol 23.12 µM -0.0767942937645824 0.468850769467374 no 1800 0.46939359512544 585 227829
SGTC_3040 9091894 49.47 µM -0.076912052218104 0.468806741368865 no 1801 0.469346754832932 570 25236966
SGTC_601 0986-0029 62.9 µM -0.0777740559093976 0.468484462922812 no 1802 0.469003892153699 589 24747981
SGTC_634 1611-4317 11.2 µM -0.0784709913926266 0.468223913831648 no 1803 0.468726702282964 589 2843522
SGTC_362 0310-0100 9.03 µM -0.0790187267025388 0.468019152720343 no 1804 0.468508863940993 587 790235
SGTC_2484 5809818 12.04 µM -0.079750954034332 0.467745435770376 no 1805 0.468217666509326 587 2870548
SGTC_440 fluspirilene 35.1 µM -0.0804616914120235 0.467479766652931 no 1806 0.467935031618677 613 3396 An atypical antipsychotic.
SGTC_2437 5741531 144.16 µM -0.0813687509942617 0.467140734597454 no 1807 0.467574349888453 592 2262990
SGTC_732 3970-1727 52.7 µM -0.0817583353262807 0.466995126795301 no 1808 0.46741944434871 581 1275699
SGTC_2980 9014342 25.29 µM -0.0823156803249142 0.466786825844543 no 1809 0.467197842819874 585 2996599
SGTC_1244 0416-0015 52.5 µM -0.0851268629715533 0.465736320153848 no 1810 0.466080267126635 597 96201
SGTC_1805 st050013 60.3 µM -0.0876930093873536 0.464777589816142 no 1811 0.465060337959976 586 4037144
SGTC_2110 5483698 200 µM -0.0879837529753476 0.46466897875849 no 1812 0.464944794653155 582 2848765 YHR062C RPP1
SGTC_2557 derrustone 83.84 µM -0.0897819717236435 0.463997289500011 no 1813 0.464230237402413 622 629853 An antioxidant.
SGTC_3345 9148410 3.559 µM -0.0907452133344761 0.463637531613132 no 1814 0.463847521882777 591 4903596
SGTC_393 acivicin 6.25 µM -0.0908301712181309 0.463605802399956 no 1815 0.463813767984631 604 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_138 0850-0259 40.9225 µM -0.091138374082295 0.463490699848619 no 1816 0.463691320699737 598 6813004
SGTC_2305 7443522 69.23 µM -0.0919263868665158 0.463196419675879 no 1817 0.4633782632666 591 5415886
SGTC_3329 9141233 27.5565 µM -0.0952892231622355 0.461940810432508 no 1818 0.462042551186911 590 4909101 YNL103W MET4
SGTC_1485 3909-9022 254 µM -0.0957394128420034 0.461772747996943 no 1819 0.461863768867968 591 714516
SGTC_1651 st011928 86.1 µM -0.0966795159501933 0.461421815709632 no 1820 0.46149045375921 594 720198
SGTC_504 lovastatin 124 µM -0.0981262561362777 0.460881818995784 no 1821 0.460916019375411 633 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0989349833584844 0.4605799923986 no 1822 0.460594946225177 606 616764
SGTC_2902 5787006 60.46 µM -0.10008429519316 0.460151094693411 no 1823 0.460138701672376 608 591003
SGTC_846 0335-0850 148 µM -0.100168184985269 0.460119790691682 no 1824 0.460105401826346 600 6819598
SGTC_820 1582-0060 59.9 µM -0.101437814510296 0.459646050768188 no 1825 0.459601459816183 603 3848840
SGTC_2916 7875993 68.79 µM -0.1024200178045 0.459279598154493 no 1826 0.459211647655998 598 1299250
SGTC_1206 3978-0017 132 µM -0.102833468505481 0.459125353156195 no 1827 0.45904757101872 631 3873677
SGTC_1959 st077091 55.8 µM -0.103313503943055 0.45894627528082 no 1828 0.458857079187108 591 821356 YKL052C ASK1
SGTC_1564 D-Arginine 115 µM -0.103504672383528 0.458874961950438 no 1829 0.458781220693977 628 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1921 5740136 50 µM -0.10555149952066 0.458111498509903 no 1830 0.457969103734197 621 1774243
SGTC_469 w7 172 µM -0.106347422997622 0.457814661821408 no 1831 0.45765335339254 593 45115570 A P450 inhibitor.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.108600896345927 0.456974365505274 no 1832 0.456759524889775 629 4114 Related to psoralen; DNA damaging agent.
SGTC_183 3914-0051 30.55 µM -0.108789995223605 0.456903861234117 no 1833 0.456684529686443 590 1596232
SGTC_1371 2421-0008 32.7 µM -0.109551799130585 0.456619841427598 no 1834 0.456382419597716 613 2827552
SGTC_1736 st036774 51 µM -0.110062538572388 0.456429437217456 no 1835 0.456179888749781 613 1272247
SGTC_2643 anethole 100 µM -0.112143225773945 0.455653858654545 no 1836 0.455354922177623 615 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3168 9103419 49.47 µM -0.112848942734687 0.455390840066036 no 1837 0.45507515772361 603 16649256
SGTC_2944 9067346 25.62 µM -0.114151102759231 0.454905580346559 no 1838 0.454559006396848 615 6473075
SGTC_758 0868-0029 16 µM -0.114404760886605 0.454811060546482 no 1839 0.454458470067675 585 762687
SGTC_24 0417-1663 219 µM -0.114557946305154 0.45475398080268 no 1840 0.45439775708552 626 4329390
SGTC_1834 st055981 52.8 µM -0.115108839912229 0.454548715300212 no 1841 0.45417942662256 603 471719 YDL150W RPC53
SGTC_2248 tofa 1.1 µM -0.117199013429299 0.4537700178368 no 1842 0.453351174350891 597 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1652 st011932 78 µM -0.117436296414828 0.453681628858831 no 1843 0.453257161337876 604 1551076
SGTC_2690 usnic acid 100 µM -0.117520139234083 0.453650397580368 no 1844 0.453223942911034 627 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1034 k072-0165 12.7 µM -0.117864860322679 0.453521992694889 no 1845 0.453087368261131 637 5835461
SGTC_1546 5-methoxyflavanone 78.7 µM -0.117991022549946 0.453474999840497 no 1846 0.453037385580239 609 147795
SGTC_645 0845-0943 5.41 µM -0.118312643171303 0.453355205672734 no 1847 0.45290996997941 604 1885106
SGTC_1518 st038567 90.8 µM -0.119116409334665 0.453055845134134 no 1848 0.452591565266355 589 77966
SGTC_3212 9128307 49.47 µM -0.119778432291363 0.452809296498122 no 1849 0.45232933373034 645 27243542
SGTC_1457 k015-0032 57.3 µM -0.12003398201582 0.452714130285192 no 1850 0.452228114402839 595 4302660
SGTC_2243 6634756 200 µM -0.120676911776648 0.452474716536221 no 1851 0.451973473528999 591 885676
SGTC_2056 5235370 200 µM -0.120708488587429 0.45246295842924 no 1852 0.451960967621683 619 5511916
SGTC_3304 9125678 46.087 µM -0.120720500556731 0.452458485600256 no 1853 0.451956210327457 607 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1112 tnp00069 1.16933 µM -0.120770427907114 0.452439894500197 no 1854 0.451936436866368 613 145826
SGTC_3321 9137793 26.8275 µM -0.120999791453827 0.452354489332672 no 1855 0.451845600188553 594 4904192
SGTC_3284 9108171 64.8615 µM -0.12154497006886 0.452151497005838 no 1856 0.451629698872232 589 8687505
SGTC_1429 4049-0205 9.46 µM -0.122312232594781 0.451865834942909 no 1857 0.451325872264366 602 22774478
SGTC_3076 9116187 49.47 µM -0.122500412245146 0.451795776951118 no 1858 0.451251359763732 640 27241210
SGTC_662 k832-1615 104 µM -0.122861351298086 0.451661406022667 no 1859 0.451108445445464 594 5878478
SGTC_1641 st009299 47.1 µM -0.124490530164889 0.451054962019413 no 1860 0.450463448943862 604 4046054
SGTC_2685 mycophenolic acid 18.85 µM -0.125106650427987 0.450825647685995 no 1861 0.450219559192639 598 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2699 st077704 54.6 µM -0.125530347727285 0.450667960941322 no 1862 0.450051850520476 612 645852
SGTC_2570 licareol 100 µM -0.125837419649198 0.450553683341358 no 1863 0.449930310300441 641 443158
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.126928381999898 0.450147712132694 no 1864 0.449498541364155 601 140250 A respiratory chain inhibitor.
SGTC_1202 1988-0068 29.6 µM -0.127073147256197 0.450093845691313 no 1865 0.449441252264239 599 2850480
SGTC_3150 9097574 49.47 µM -0.127764674016876 0.449836544680642 no 1866 0.449167603471024 635 17217476
SGTC_1426 4048-4480 71.7 µM -0.127919819954488 0.449778821381025 no 1867 0.44910621292482 625 14224343
SGTC_2967 9089538 49.85 µM -0.129576159467427 0.449162633354056 no 1868 0.448450883095063 605 728216
SGTC_1264 0783-0040 158 µM -0.12987975860975 0.449049702274324 no 1869 0.448330779458049 602 2855798
SGTC_1205 4161-2785 76 µM -0.132678590974016 0.448008804136516 no 1870 0.447223787540362 660 3498106
SGTC_3049 9092223 49.47 µM -0.132776490724668 0.44797240122272 no 1871 0.447185073699972 635 8623917
SGTC_884 0851-0618 334 µM -0.132832166505101 0.44795169900959 no 1872 0.447163057287371 645 9642473
SGTC_762 1165-0429 115 µM -0.134562312719259 0.44730844073404 no 1873 0.446478970310208 596 5967793
SGTC_2688 kanamycin b 96.69 µM -0.13600917594994 0.446770611746671 no 1874 0.445907013508067 611 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_560 2332-1943 155 µM -0.136721172955853 0.446505983610109 no 1875 0.445625596545549 605 21177716
SGTC_2920 7982904 15.77 µM -0.137822973584306 0.446096524040943 no 1876 0.44519016366606 624 6456808
SGTC_2308 7584454 197.62 µM -0.139095188165682 0.445623805460055 no 1877 0.444687465276138 640 893577
SGTC_754 3474-0146 171 µM -0.139691737669056 0.445402171290972 no 1878 0.44445177739048 607 24762078
SGTC_2014 4013930 200 µM -0.140569374018828 0.445076136842113 no 1879 0.444105071973622 635 64556
SGTC_2919 7978188 46.38 µM -0.143837149087796 0.443862514562257 no 1880 0.442814533576585 589 2980291
SGTC_1631 benzylvanillin 81.9 µM -0.143855668273693 0.443855638192122 no 1881 0.442807221532653 623 75506
SGTC_1998 st075797 76.8 µM -0.145193863583227 0.443358796950672 no 1882 0.442278905373361 623 24208315
SGTC_2098 5376439 882.5 nM -0.147083295651417 0.442657445913985 no 1883 0.441533137306992 619 2844116
SGTC_1966 st070145 16.1 µM -0.147221554561925 0.442606131684011 no 1884 0.441478573944637 608 3748532
SGTC_2816 7982706 58.44 µM -0.148651288447078 0.442075548404949 no 1885 0.440914400120567 616 2981853
SGTC_146 3448-8650 53.125 µM -0.149253212759105 0.441852201513695 no 1886 0.440676916233931 649 2891488 YIL048W NEO1
SGTC_2756 carbadox 75.1 µM -0.15025843305185 0.441479250969972 no 1887 0.440280363109464 606 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1355 1499-0035 1.68 µM -0.151882230977355 0.440876909356037 no 1888 0.43963991165857 623 1548538
SGTC_2444 5485484 36.41 µM -0.153446661461407 0.440296719193044 no 1889 0.439023025018506 644 6790631
SGTC_298 1391-0729 10 µM -0.154055428194913 0.440070984403468 no 1890 0.438783015898619 613 3237558
SGTC_3068 9116768 49.47 µM -0.154374560894145 0.439952655634767 no 1891 0.438657205332553 617 41904888
SGTC_3228 9131799 49.47 µM -0.154408916338718 0.439939917562254 no 1892 0.438643661875299 614 17015818
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.154670195865284 0.439843044194016 no 1893 0.438540663723532 601 2724 A muscle relaxant with antifungal properties.
SGTC_8 0354-0001 70 µM -0.15552323240149 0.439526792995934 no 1894 0.438204419981054 630 4993152
SGTC_987 1497-1013 404 µM -0.155741953934797 0.439445711296967 no 1895 0.438118213091807 613 1676435
SGTC_1898 st060199 18.6 µM -0.1561403181275 0.439298041257199 no 1896 0.43796120940541 608 688866
SGTC_1621 st003705 32.4 µM -0.157245711015458 0.438888326310997 no 1897 0.437525602095486 612 24207032
SGTC_981 1488-1094 54.9 µM -0.15878344462088 0.438318472839845 no 1898 0.436919746301548 596 3449522
SGTC_1332 1480-0653 17.5 µM -0.158934357544628 0.438262554384728 no 1899 0.436860295661026 598 5749438
SGTC_994 3910-0338 138 µM -0.160158582829388 0.437808982248548 no 1900 0.436378077142055 617 3479481
SGTC_2326 6164455 177.58 µM -0.160917257799088 0.437527936202899 no 1901 0.436079284842329 626 2888790
SGTC_2797 7859098 81.82 µM -0.161970057501924 0.437137985866908 no 1902 0.43566471656928 607 972681
SGTC_1405 3909-7894 12 µM -0.163327980288011 0.436635110098928 no 1903 0.43513010230352 609 7104060
SGTC_1456 k015-0012 13 µM -0.163500754900389 0.436571134282674 no 1904 0.435062089412279 641 2989616
SGTC_2567 aureobasidin a 60 nM -0.163908820957011 0.436420040205915 no 1905 0.434901461450265 618 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_640 3381-0960 37.1 µM -0.16426444329295 0.436288371959976 no 1906 0.43476148578837 633 1745025
SGTC_2761 levamisole 97.89 µM -0.165675274922384 0.435766084913051 no 1907 0.434206252437986 630 26879 An alkaline phosphatase inhibitor.
SGTC_2882 9058044 58.44 µM -0.166078573698043 0.43561680505904 no 1908 0.434047557846115 639 18076804
SGTC_2282 7944268 200 µM -0.166179278989589 0.435579530722469 no 1909 0.434007932839376 649 2970414
SGTC_1017 4239-0030 168 µM -0.166444134609212 0.435481501689875 no 1910 0.433903721961514 602 1149593
SGTC_614 0462-0418 107 µM -0.166605044035894 0.435421947420998 no 1911 0.43384041230394 618 5188303
SGTC_1266 0828-0227 32.9 µM -0.168609980791115 0.434680022513482 no 1912 0.433051714717193 629 3913820
SGTC_1031 k035-0009 16 µM -0.168654282453902 0.434663631313265 no 1913 0.433034290425972 671 5180959
SGTC_2227 7312221 64.1025 µM -0.168818352233305 0.434602928010192 no 1914 0.43296976125951 607 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_109 0132-0036 33.701 µM -0.168837733731118 0.434595757254923 no 1915 0.432962138572734 599 67274 A color developer.
SGTC_699 0375-0592 111 µM -0.169209418397735 0.434458245744007 no 1916 0.432815960902543 602 762578
SGTC_2592 piperlongumine 83.33 µM -0.169470376880428 0.434361704138107 no 1917 0.432713335572056 637 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2489 cantharidin 73.42 µM -0.171214664215891 0.433716505734856 no 1918 0.432027488686429 622 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2812 7970281 58.44 µM -0.172390879057115 0.433281532529968 no 1919 0.431565121147059 649 2233435
SGTC_2994 9053520 71.4286 µM -0.172832931360438 0.433118079085375 no 1920 0.431391375534551 667 4647384
SGTC_1071 trifluoperazine 6.31 µM -0.17294220044133 0.433077677466781 no 1921 0.431348430119869 651 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1778 st046819 58.9 µM -0.173098838984522 0.433019762480165 no 1922 0.431286868766452 601 671715
SGTC_3320 9137005 35.139 µM -0.173462012320369 0.43288548957873 no 1923 0.431144142491031 624 4908713
SGTC_880 0833-0487 87.2 µM -0.173469186550332 0.432882837191421 no 1924 0.431141323125859 610 76075
SGTC_565 1418-0001 44.5 µM -0.17497539936203 0.432326041815652 no 1925 0.430549481912008 663 2862145
SGTC_2707 st078556 66.6 µM -0.175754286669387 0.432038166449178 no 1926 0.430243492224508 609 17250899
SGTC_132 0417-1715 25.805 µM -0.17657970256011 0.431733133582713 no 1927 0.429919269272192 636 6769098
SGTC_584 0986-0246 15.4 µM -0.176857236860937 0.431630579773215 no 1928 0.429810264540964 650 53315 YDR232W HEM1
SGTC_188 3229-0966 278.469 µM -0.177872793865055 0.431255352915592 no 1929 0.429411438727306 626 5722370
SGTC_1870 st057514 26.5 µM -0.17796448103092 0.431221479492907 no 1930 0.429375435220057 605 5393161
SGTC_3236 9132701 49.47 µM -0.178006200751737 0.431206066491841 no 1931 0.42935905300966 653 24282524
SGTC_1841 st054148 70 µM -0.178801471887165 0.430912280296731 no 1932 0.42904679475515 663 675442
SGTC_1883 5-benzylidenerhodanine 20 µM -0.178992127195304 0.430841854774804 no 1933 0.428971941727386 614 1273210
SGTC_2800 7887935 81.82 µM -0.180308740437331 0.430355575594048 no 1934 0.42845509712667 647 2961002
SGTC_1434 4073-0095 163 µM -0.181204745215338 0.430024704681698 no 1935 0.428103435058818 627 24133745
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.181601348881038 0.429878265090977 no 1936 0.427947795099525 621 756377
SGTC_3248 9135562 49.47 µM -0.181900604709903 0.429767776023641 no 1937 0.427830364962658 622 17650701
SGTC_2487 5918373 44.05 µM -0.182288569396509 0.429624542704121 no 1938 0.427678134349485 618 2876279
SGTC_205 1486-1330 71.903 µM -0.182600678273101 0.429509321438264 no 1939 0.427555676053283 622 4118834
SGTC_624 k048-0052 28 µM -0.183436015306933 0.429200969548274 no 1940 0.427227959568869 622 6835531
SGTC_3048 9093155 49.47 µM -0.184502451284458 0.428807373817948 no 1941 0.426809652161202 611 25236002
SGTC_2256 7954252 200 µM -0.184770403874165 0.428708490109182 no 1942 0.42670456120555 649 2972920
SGTC_376 3970-0862 59.1 µM -0.188294985828925 0.427408217162145 no 1943 0.425322707892143 669 3135186
SGTC_259 usnic acid 108.925 µM -0.18902324632213 0.427139648355384 no 1944 0.425037298641057 684 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1055 3448-0672 86 µM -0.189145766394102 0.427094468566421 no 1945 0.424989286214677 662 748378
SGTC_2765 myclobutanil 7.74 µM -0.189611545185208 0.426922719422304 no 1946 0.424806769794113 655 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3298 9116858 71.43 µM -0.189692221311158 0.426892972682688 no 1947 0.424775158317375 666 2506942
SGTC_3280 9140961 49.47 µM -0.190789302322795 0.426488500505771 no 1948 0.424345335121981 640 4901226
SGTC_441 propafenone 146 µM -0.191715374376953 0.426147136112547 no 1949 0.423982581183936 619 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2476 5806916 10.51 µM -0.191779054422851 0.426123664699078 no 1950 0.423957639281152 642 2870194
SGTC_2691 st077356 60.2 µM -0.193080563430309 0.425644007416326 no 1951 0.423447937185751 654 2839272
SGTC_2369 9071472 200 µM -0.193925268785938 0.425332759079263 no 1952 0.423117198821034 628 17296037
SGTC_540 1187-0821 17.3 µM -0.194467878524383 0.425132848358197 no 1953 0.422904772405578 644 847520
SGTC_2996 9066192 71.4286 µM -0.194520812961219 0.425113347044546 no 1954 0.422884050289316 651 6472854
SGTC_2521 angolensin 13.4 µM -0.194567363848962 0.425096197614019 no 1955 0.422865827301939 623 821428 A flavenoid.
SGTC_1470 k295-0292 231 µM -0.197819082646663 0.423898611139392 no 1956 0.421593307704407 623 5045612
SGTC_3305 9127027 53.8275 µM -0.197944736000086 0.423852347868839 no 1957 0.421544151169638 643 41905295
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.198595628334176 0.423612718007721 no 1958 0.421289536790887 654 23847180
SGTC_3313 9133968 57.047 µM -0.198724975495066 0.423565101447347 no 1959 0.421238943019799 636 1494643
SGTC_1061 3448-9325 110 µM -0.198836654423334 0.42352398998995 no 1960 0.421195261173355 639 723482
SGTC_2049 5262831 67.185 µM -0.201889005163365 0.422400676690946 no 1961 0.420001748851846 655 763417
SGTC_3185 9108267 49.47 µM -0.202533343458077 0.422163630351976 no 1962 0.419749897091651 651 4910486
SGTC_348 k064-0012 10.7 µM -0.202864330097589 0.422041874260763 no 1963 0.419620537499331 634 5066323
SGTC_1495 4469-0029 237 µM -0.202952489027105 0.422009445547193 no 1964 0.419586083786781 649 793680
SGTC_814 3342-0569 96 µM -0.206514760630921 0.420699530827301 no 1965 0.418194417962984 631 4346283
SGTC_777 1315-0167 517 µM -0.207226301574184 0.42043798843899 no 1966 0.417916563712007 630 4221767
SGTC_99 0109-0120 622.8 µM -0.209561439811182 0.419579904829243 no 1967 0.41700498894483 682 759414
SGTC_1935 st074532 41.6 µM -0.21078264119092 0.419131306965391 no 1968 0.416528442278097 649 2829742
SGTC_559 1550-0661 158 µM -0.210879057359704 0.419095893781195 no 1969 0.416490823228645 653 5830875
SGTC_2585 alliin 100 µM -0.211676489139787 0.418803026167957 no 1970 0.416179715706894 661 87310 A garlic compound which reacts with lipids.
SGTC_2467 5474540 200 µM -0.211993834628868 0.418686489249148 no 1971 0.416055922133687 629 5413519
SGTC_1282 0886-0010 32.4 µM -0.213143550316937 0.418264345742286 no 1972 0.41560749838511 643 2836211 YNL267W PIK1
SGTC_3322 9139058 2.11 µM -0.214391578249251 0.417806211287763 no 1973 0.415120854287866 631 4908926 YPR165W RHO1
SGTC_3050 9093513 49.47 µM -0.214643111518795 0.417713890253845 no 1974 0.415022789546777 635 25236664
SGTC_209 4077-0173 175.592 µM -0.214854049932178 0.417636472371513 no 1975 0.414940555517347 616 15993494
SGTC_1408 3909-7976 48.8 µM -0.215061498122057 0.417560338572256 no 1976 0.414859685781239 642 24152374
SGTC_726 3448-4391 34.2 µM -0.215061530240786 0.417560326784873 no 1977 0.414859673260641 675 1356692
SGTC_1608 st001473 40.5 µM -0.215206046046876 0.417507291091975 no 1978 0.414803338651198 672 7292267
SGTC_3189 9110682 49.47 µM -0.215596364213856 0.417364056169923 no 1979 0.414651195046824 663 17122418
SGTC_22 0964-0034 14.468 µM -0.215756805643601 0.417305182213114 no 1980 0.414588659682657 641 138402
SGTC_1310 1188-0297 994 nM -0.21786020903318 0.416533510634636 no 1981 0.413769015518236 645 1588352
SGTC_927 2425-1185 123 µM -0.219697851418778 0.415859601351776 no 1982 0.413053239053851 652 730375
SGTC_660 4031-1742 102 µM -0.220022370269992 0.41574061783883 no 1983 0.412926866306001 634 6738706
SGTC_1345 1488-0192 31.4 µM -0.220601517408807 0.415528295102359 no 1984 0.412701359723717 666 658348
SGTC_1558 st069300 45.6 µM -0.221028381619914 0.415371817014922 no 1985 0.412535167050969 642 24208000
SGTC_1926 methyl fluorone black 53.6 µM -0.221570665160362 0.415173048353072 no 1986 0.412324060345742 627 72721 Reacts with homocysteine.
SGTC_3164 9100705 49.47 µM -0.222304491372726 0.414904106196202 no 1987 0.41203842798447 654 17174235
SGTC_1243 0416-0003 5.65 µM -0.223721522307153 0.414384887255753 no 1988 0.411486999002966 662 2141977
SGTC_2971 9092186 9.93 µM -0.223799663736403 0.414356259542318 no 1989 0.411456595815754 619 25236400
SGTC_359 0081-0058 15.9 µM -0.2268636189204 0.413234116148064 no 1990 0.410264896188483 647 3494159
SGTC_2616 abietic acid 100 µM -0.227187426835832 0.41311556592232 no 1991 0.410139002015761 646 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2128 5255449 168.493 µM -0.227244148807671 0.413094800096948 no 1992 0.410116949876725 636 736008
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.227919528028752 0.41284756351715 no 1993 0.409854400531989 645 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_800 3448-7362 155 µM -0.228579452789589 0.412606017751596 no 1994 0.409597898043969 648 15991913
SGTC_2030 5175110 200 µM -0.23112017649064 0.411676371393037 no 1995 0.408610720422213 691 2831986
SGTC_556 4058-0063 51.5 µM -0.232344084259197 0.411228722219988 no 1996 0.40813538741541 666 6615692
SGTC_2370 9071495 200 µM -0.234165543185386 0.410562730435123 no 1997 0.407428231976486 681 21791103
SGTC_2870 9038528 12.99 µM -0.234389760089558 0.410480766343068 no 1998 0.407341203762801 670 6463316
SGTC_1925 st057770 10.1 µM -0.234766756550274 0.410342961407081 no 1999 0.407194885551279 654 5989122
SGTC_3315 9136395 68.55 µM -0.235019058094147 0.410250742855523 no 2000 0.407096970615435 709 16876844
SGTC_2026 5148700 152 µM -0.235373523493553 0.410121190853308 no 2001 0.406959417030263 637 79838
SGTC_2032 5185112 25.99 µM -0.235704177176428 0.410000350533355 no 2002 0.40683111414756 628 5718189
SGTC_2371 9071574 200 µM -0.237576730657782 0.409316170838007 no 2003 0.406104700036502 684 45596039
SGTC_1912 st060209 90.8 µM -0.241174480855844 0.408002428168766 no 2004 0.404709944268593 687 688787
SGTC_1563 conessine 56.1 µM -0.2415766920941 0.40785562199667 no 2005 0.404554092119989 645 441082 An anti-amoebic, histamine inhibitor.
SGTC_156 3474-0145 5.642 µM -0.24165797334293 0.407825956099399 no 2006 0.404522598425619 635 2265471
SGTC_1048 3161-0300 24.5 µM -0.241836119251853 0.407760938545541 no 2007 0.404453575163777 638 2165101
SGTC_2863 9028737 58.44 µM -0.242056356913142 0.407680562361248 no 2008 0.404368247414485 678 6460917
SGTC_1700 st030840 7.9285 µM -0.244089562345994 0.406938723832893 no 2009 0.403580728073395 644 5499307
SGTC_3281 9140613 49.47 µM -0.244112565231903 0.406930332868224 no 2010 0.403571820619126 644 16013766
SGTC_753 1322-0200 289 µM -0.244453821007217 0.406805855022799 no 2011 0.403439681329144 669 5403907
SGTC_1171 0368-0077 21.4 µM -0.246598951386312 0.406023604614888 no 2012 0.402609308081411 638 3239779
SGTC_428 3448-4153 16.5 µM -0.246887286789568 0.405918487788408 no 2013 0.402497727751705 644 3834874
SGTC_2471 5466956 24.79 µM -0.247431420791738 0.405720134379651 no 2014 0.402287179863183 649 724419
SGTC_1219 1469-0211 33.1 µM -0.247518299170757 0.40568846680517 no 2015 0.402253565657639 683 6822282
SGTC_3217 9129673 49.47 µM -0.249684087612193 0.404899226807282 no 2016 0.401415832386955 675 17248312
SGTC_730 1436-0052 41.2 µM -0.249996487431904 0.404785416299295 no 2017 0.401295032515764 633 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2005 4024620 188 µM -0.250308596082052 0.404671719910204 no 2018 0.401174354655827 672 236743
SGTC_60 0986-0278 202 µM -0.250488716551334 0.40460610845086 no 2019 0.401104714759737 688 3110598
SGTC_2190 6049624 200 µM -0.252664229842862 0.403813858953015 no 2020 0.400263845800073 648 2265554
SGTC_3311 9131146 2.8755 µM -0.253531498377395 0.40349813841409 no 2021 0.399928761939593 661 4900406 YPR165W RHO1
SGTC_1279 0874-0590 65.2 µM -0.254115610939914 0.403285533431803 no 2022 0.399703121679098 652 3523074
SGTC_1683 st010134 710 nM -0.254568066745079 0.403120868448452 no 2023 0.399528362892021 707 3818134
SGTC_721 1187-1332 279 µM -0.256171287209893 0.402537537171021 no 2024 0.398909289267605 676 25730
SGTC_2652 actinonin 100 µM -0.257676700627293 0.401989990409182 no 2025 0.398328214611379 649 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_763 3453-1109 128 µM -0.257989411945366 0.401876275593152 no 2026 0.398207539370334 671 1560353
SGTC_1906 st060206 94.7 µM -0.258067036989038 0.401848049191551 no 2027 0.398177585387841 670 5133468
SGTC_2184 6075246 200 µM -0.259938812873998 0.401167580147434 no 2028 0.397455485842847 637 2267320
SGTC_1630 st005209 31.3 µM -0.260073851508289 0.401118499505458 no 2029 0.397403403773186 644 3367314
SGTC_1256 0570-0116 285 µM -0.260230534359119 0.401061554092371 no 2030 0.397342976195317 682 410638
SGTC_2549 cedrol 20.94 µM -0.260963715450944 0.400795111908039 no 2031 0.397060244396131 650 6708665 A sedative which affects the nervous system.
SGTC_168 3970-0862 530.542 µM -0.261423783991064 0.4006279439347 no 2032 0.396882858803991 645 3135186
SGTC_1134 3477-0009 42.5 µM -0.261842664926108 0.400475757489532 no 2033 0.39672137219821 659 3973534
SGTC_151 3013-0144 2.285 µM -0.262281714887406 0.400316259516861 no 2034 0.396552129058537 687 906558 YHR107C CDC12
SGTC_673 1082-0474 110 µM -0.262505241637354 0.400235063152945 no 2035 0.396465972387975 685 3098046
SGTC_101 0490-5701 117.494 µM -0.263088382945016 0.400023256670233 no 2036 0.396241228852778 666 4661669
SGTC_3254 9136651 49.47 µM -0.263098259691689 0.400019669527012 no 2037 0.396237422636502 674 16454030
SGTC_1507 4075-3230 155 µM -0.263630584291274 0.399826346634125 no 2038 0.396032294569884 668 659771
SGTC_2736 butenafine 14.65 µM -0.263719147701821 0.399794185679422 no 2039 0.395998169986401 666 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_532 1548-0774 215 µM -0.264625783030798 0.399464988875174 no 2040 0.395648878004912 701 5932993
SGTC_1186 1319-0216 26 µM -0.265287869921771 0.399224632074991 no 2041 0.395393854123739 646 4565136
SGTC_223 busulfan 5 mM -0.266381234844555 0.398827792469585 no 2042 0.39497280785865 669 2478 A DNA alkylator.
SGTC_2934 9036370 36.88 µM -0.266812173102276 0.398671411028198 no 2043 0.394806890573056 665 6462800
SGTC_1009 4106-0057 9.87 µM -0.268299526060676 0.398131796640737 no 2044 0.394234385500395 681 2928005
SGTC_617 3770-0098 35 µM -0.268788365370261 0.397954487317544 no 2045 0.39404627353289 676 5962639
SGTC_3347 9188721 44.724 µM -0.270332505970901 0.397394543027147 no 2046 0.393452229913813 701 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1389 3405-0187 19 µM -0.270551437862416 0.397315169889938 no 2047 0.393368025047131 654 799890
SGTC_1716 st033144 30.6155 µM -0.271285529414045 0.397049058127048 no 2048 0.393085717580503 700 674617
SGTC_1197 1601-0112 267 µM -0.271778752300606 0.396870289338259 no 2049 0.392896071845314 672 7350313
SGTC_2783 7738165 71.43 µM -0.272347489447532 0.396664177285491 no 2050 0.39267742220023 655 17201110
SGTC_2317 5986382 200 µM -0.273576780183222 0.396218777331441 no 2051 0.392204940087577 664 877883
SGTC_2794 7785382 27.27 µM -0.273704531822891 0.396172497769395 no 2052 0.392155847408282 697 2205081
SGTC_2941 9056145 11.23 µM -0.275313333441091 0.395589815549611 no 2053 0.391537760772901 694 2119517
SGTC_1493 4348-0038 111 µM -0.275471409974464 0.395532575324041 no 2054 0.391477043981399 675 800424
SGTC_1512 0259-0544 12.2 µM -0.275625736009633 0.395476695344641 no 2055 0.391417770297179 640 18476
SGTC_930 2810-3379 265 µM -0.276525217177565 0.39515104462434 no 2056 0.391072346963732 712 1015764
SGTC_1469 k284-2957 126 µM -0.277066705448863 0.394955037961133 no 2057 0.390864443291124 668 23884841
SGTC_1067 clotrimazole 1.36 µM -0.278036515905832 0.394604054696525 no 2058 0.390492163897855 654 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2533 agelasine 13.65 µM -0.279863455664398 0.393943101057732 no 2059 0.38979113271164 673 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1991 st073000 8.92 µM -0.279881061081993 0.393936733219775 no 2060 0.389784378921167 689 4301969 YIL048W NEO1
SGTC_2663 amphotericin b 100 µM -0.280719961461866 0.393633337831828 no 2061 0.389462598556939 673 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1162 k048-0130 20.1 µM -0.280808473643866 0.393601330417947 no 2062 0.389428652001608 688 6797406
SGTC_608 k048-0125 159 µM -0.281592157949219 0.39331796908418 no 2063 0.389128127014606 693 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2986 9022445 71.43 µM -0.282262336981995 0.393075693330834 no 2064 0.388871181295489 703 6459286
SGTC_1788 fluconazole 20 µM -0.283404960976767 0.392662720002972 no 2065 0.388433212954696 701 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1414 3917-0015 5.4 µM -0.283791531284017 0.392523031005189 no 2066 0.38828507244141 684 6618702
SGTC_2176 5809774 33.9695 µM -0.283891239537572 0.392487003204397 no 2067 0.388246865127617 675 2870539
SGTC_1690 st023502 41.2 µM -0.284467047517249 0.392278963284067 no 2068 0.388026241810957 656 24207482
SGTC_549 1661-1316 519 µM -0.284764780855881 0.392171404042026 no 2069 0.38791217816355 694 2857282
SGTC_1077 5-fluorocytosine 377 nM -0.28551978643742 0.391898687433087 no 2070 0.387622973815188 701 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1042 0350-0096 82 µM -0.285819922164001 0.391790289736471 no 2071 0.387508024346992 655 3122515
SGTC_1360 1598-0022 39.8 µM -0.286116956723019 0.391683020334514 no 2072 0.387394272308144 698 761525
SGTC_2200 6600604 21.907 µM -0.286567165781347 0.391520450051235 no 2073 0.387221879158885 698 2904777
SGTC_2130 NSC 7 2.4545 µM -0.287921955802893 0.391031350389394 no 2074 0.386703239971818 677 21448
SGTC_1548 st061468 90.8 µM -0.288112367746451 0.390962622593612 no 2075 0.386630362878296 675 390799
SGTC_1175 0741-0056 27.6 µM -0.288326708983727 0.390885261768819 no 2076 0.386548332017663 670 765927
SGTC_1992 st073643 23.3 µM -0.289503203076735 0.390460714181166 no 2077 0.386098164544837 679 3161292
SGTC_1409 3909-8004 61.9 µM -0.290049917509553 0.390263472179019 no 2078 0.385889024764599 653 2119279
SGTC_1274 0865-0114 173 µM -0.29061244223217 0.390060555668497 no 2079 0.385673871541011 653 870624
SGTC_2963 9082507 9 µM -0.291191352692636 0.389851759693929 no 2080 0.385452487858201 709 16459611
SGTC_2080 5212524 12.4 µM -0.292626002382996 0.389334460838278 no 2081 0.384904018161553 678 260183
SGTC_130 0136-0219 337.655 µM -0.293256859870887 0.389107051385724 no 2082 0.384662912782252 713 234244
SGTC_2411 st077133 39.94 µM -0.293939465925189 0.388861030562714 no 2083 0.384402080027816 728 1403142 YNL221C POP1
SGTC_16 erodoxin 22.806 µM -0.294243105575036 0.388751608876025 no 2084 0.384286072131895 688 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1029 k015-0030 64.7 µM -0.294377308799223 0.388703249284755 no 2085 0.384234802045721 676 2208316
SGTC_1059 3448-6867 171 µM -0.295371595225611 0.388345015947721 no 2086 0.383855014776385 671 3934407
SGTC_2095 5432005 200 µM -0.295815714360423 0.388185034088144 no 2087 0.383685410743309 695 783734
SGTC_912 3474-0017 2.18 µM -0.296653318247578 0.387883361681188 no 2088 0.383365600031181 707 3360550
SGTC_2043 5101342 149 µM -0.297492837898103 0.387581067175359 no 2089 0.383045137578614 676 678451
SGTC_1301 naphtanilide LB 4.81 µM -0.29926880989708 0.386941799345457 no 2090 0.382367475370188 697 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2669 eugenol 100 µM -0.299778147207263 0.386758517950565 no 2091 0.382173192578101 681 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_809 3998-0021 90 µM -0.300319118642939 0.386563880896285 no 2092 0.381966875676716 711 715485
SGTC_894 0960-0238 55.9 µM -0.300611478616067 0.386458704066773 no 2093 0.381855388721172 687 6741907 YDL195W SEC31
SGTC_3111 9122088 49.47 µM -0.301156516220493 0.386262648449813 no 2094 0.381647573223255 695 16876704
SGTC_2226 7298446 200 µM -0.301322624694589 0.386202903298724 no 2095 0.381584245078216 698 3283010
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.301353939921615 0.386191640280543 no 2096 0.381572306636949 703 7104
SGTC_2047 4141938 200 µM -0.301846202525842 0.386014602834921 no 2097 0.381384654018635 677 3807862
SGTC_444 curcumin 90.4 µM -0.304927328203903 0.384907046593161 no 2098 0.380210750715099 689 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_780 0109-0199 192 µM -0.305849166721313 0.384575860067214 no 2099 0.379859745701102 704 610414
SGTC_210 3551-0445 56.827 µM -0.305858826001018 0.384572390248389 no 2100 0.379856068296567 715 2865180 YOR207C RET1
SGTC_1735 st034310 56.75 µM -0.306055318678207 0.384501807904966 no 2101 0.379781263518212 697 871153
SGTC_1723 st034307 2.5525 µM -0.308940812280437 0.383465748784075 no 2102 0.378683275313516 662 867466
SGTC_235 0330-0087 5 mM -0.310544928075677 0.382890138076771 no 2103 0.378073299672006 681 46494818 YHR062C RPP1
SGTC_2665 lovastatin 100 µM -0.311732585747531 0.382464133043388 no 2104 0.377621880627175 687 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1378 2093-0007 380 nM -0.311740227130617 0.382461392589155 no 2105 0.377618976739862 697 3618014
SGTC_2328 6201408 200 µM -0.311772655163561 0.38244976288303 no 2106 0.377606653477927 716 2890418
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.314275957493645 0.381552321173214 no 2107 0.376655728478647 704 229346 A bile salt which induces apoptosis.
SGTC_216 k038-0035 28.382 µM -0.314633401837227 0.381424228069968 no 2108 0.376520007621298 670 4444231 YPR107C YTH1
SGTC_2165 5727197 32.143 µM -0.314695221408935 0.381402075837856 no 2109 0.376496536409019 689 1361712
SGTC_59 0330-0160 1.33 µM -0.315224050677281 0.381212592695041 no 2110 0.37629577296777 675 4293482
SGTC_1874 staurosporine 7.6 µM -0.316126103232896 0.380889446827616 no 2111 0.375953397209205 690 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2917 7979103 53.79 µM -0.316754621414379 0.380664339349674 no 2112 0.375714899630877 713 2980565
SGTC_2291 7917025 104.35 µM -0.316773111164004 0.380657717748549 no 2113 0.375707884226914 680 2964612
SGTC_2791 5663188 71.43 µM -0.318674252407223 0.379977062629402 no 2114 0.374986770541998 719 54690634
SGTC_232 clozapine 119 µM -0.319561691945205 0.379659464631028 no 2115 0.374650309055259 679 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2183 6420625 130.508 µM -0.319587157062602 0.379650352339182 no 2116 0.374640655684741 672 2897619
SGTC_491 tetrandrine 80.3 µM -0.320491995542132 0.379326613532408 no 2117 0.37429769863391 703 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_66 0109-0187 42.4 µM -0.321847237790671 0.378841884739269 no 2118 0.373784213059976 678 759417
SGTC_1982 st072467 71.9 µM -0.323666020305035 0.378191661232777 no 2119 0.37309544951204 712 3163533
SGTC_602 3130-1533 38.1 µM -0.323747443997001 0.378162559921726 no 2120 0.373064624244477 696 720941
SGTC_1103 duloxetine 36.1 µM -0.323752468424997 0.378160764183963 no 2121 0.373062722130161 696 60835 A selective serotonin reuptake inhibitor.
SGTC_1661 st013063 9.66 µM -0.324139183380939 0.378022559604699 no 2122 0.372916331457839 704 721395
SGTC_2429 5902844 64.44 µM -0.324233696603133 0.377988784747309 no 2123 0.372880556334086 699 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1794 st048918 76.9 µM -0.324549863192233 0.377875807530906 no 2124 0.372760888996663 681 672303
SGTC_2670 beta-carotene 100 µM -0.324785669974974 0.377791552441719 no 2125 0.372671645403046 670 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2806 7952793 58.44 µM -0.32519587017596 0.377644999458945 no 2126 0.372516417047267 676 2972490
SGTC_2012 4023501 200 µM -0.326082354495139 0.377328343755502 no 2127 0.372181023550849 737 3477460
SGTC_1312 1218-2183 165 µM -0.326931980712739 0.377024931292555 no 2128 0.371859665963163 678 6744073
SGTC_3230 9131665 49.47 µM -0.327841293828882 0.376700287976265 no 2129 0.371515831638168 691 15943720
SGTC_926 2268-1401 59.4 µM -0.329209536582608 0.376211961756953 no 2130 0.370998657595739 698 2931578
SGTC_153 4077-0274 519.67 µM -0.330489155875342 0.375755444521751 no 2131 0.370515192560896 652 3121976
SGTC_2619 obliquin 87.91 µM -0.331940114088984 0.375238010743023 no 2132 0.369967239693068 684 6708593 A bioactive alkalod. YER133W GLC7
SGTC_837 0091-0265 12.5 µM -0.335332474855553 0.374029120404181 no 2133 0.368687149520826 691 759367
SGTC_569 4130-2812 160 µM -0.33540908437088 0.374001834342546 no 2134 0.368658258062936 725 743552
SGTC_1280 0880-0253 10.1 µM -0.336986930275655 0.373439992511459 no 2135 0.368063376299356 715 6836607
SGTC_655 k060-0012 42 µM -0.337638121079008 0.373208193803186 no 2136 0.367817955503072 703 5994525
SGTC_897 1000-0139 31.4 µM -0.339500578242277 0.372545484708125 no 2137 0.367116330774105 709 6151020
SGTC_3203 9113543 49.47 µM -0.340304858153384 0.372259418175756 no 2138 0.366813479490823 684 17018012
SGTC_145 3737-0113 38.366 µM -0.340458467373558 0.372204790410644 no 2139 0.366755647420375 689 6849351
SGTC_1499 4480-0877 67.3 µM -0.342171932531851 0.371595608512166 no 2140 0.366110753181049 683 2861909
SGTC_2973 9094665 17.96 µM -0.344332768401338 0.370827832971423 no 2141 0.365298021833147 735 25237061 YIL048W NEO1
SGTC_338 4055-0136 114 µM -0.345262709179211 0.370497569889804 no 2142 0.364948439328322 692 2900563
SGTC_1028 k015-0029 4.8 µM -0.345890139443051 0.370274795558403 no 2143 0.364712639690691 672 4588309
SGTC_1986 st071812 45 µM -0.347147575931069 0.369828463310254 no 2144 0.364240226435298 704 11838594
SGTC_331 k048-0133 24.5 µM -0.347332777710887 0.369762739974239 no 2145 0.364170664359717 672 6813582
SGTC_2415 st077333 57.7 µM -0.348599169497785 0.369313432222546 no 2146 0.363695125657274 671 2766255
SGTC_3339 9145883 14.936 µM -0.349760147233834 0.368901681473656 no 2147 0.363259355036592 728 2030670
SGTC_1973 st070275 50.2 µM -0.352504216688964 0.367929072288082 no 2148 0.362230078351253 695 17118334
SGTC_1081 sertraline 6 µM -0.353311475129088 0.367643108042632 no 2149 0.361927471835356 706 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3128 9127691 49.47 µM -0.353324040841313 0.367638657328409 no 2150 0.361922762171203 732 41316314
SGTC_727 3032-0951 202 µM -0.354528189435421 0.367212236297743 no 2151 0.361471541008722 711 3652836
SGTC_1309 pyrazolanthrone 13.4 µM -0.355548835897184 0.366850926429508 no 2152 0.361089232939437 696 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3152 9099253 49.47 µM -0.356228679383204 0.366610326568432 no 2153 0.360834657898177 717 25236131
SGTC_745 0469-0705 296 µM -0.35894403395232 0.36564987311671 no 2154 0.359818478670448 722 3486736
SGTC_268 camptothecin 39.6153 µM -0.359416611922008 0.365482802443803 no 2155 0.35964172466697 717 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_433 pimozide 108 µM -0.360786753271609 0.364998560190633 no 2156 0.359129433076172 697 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1465 k213-0056 144 µM -0.362269745749206 0.36447467607806 no 2157 0.35857523214134 710 24048857 YMR208W ERG12
SGTC_1455 4262-0120 131 µM -0.362650883333555 0.364340075686685 no 2158 0.35843284735647 688 1529587
SGTC_2899 9053889 58.44 µM -0.3629050142288 0.364250337552839 no 2159 0.358337920466668 718 6470052
SGTC_1228 0124-0032 52.5 µM -0.363372823661353 0.364085165191804 no 2160 0.358163199969294 694 X1228
SGTC_2651 TUB2.036 5 µM -0.363444134643171 0.364059989200375 no 2161 0.358136568889594 693 15992207 YFL037W TUB2
SGTC_553 k007-0256 45.7 µM -0.364116231870407 0.363822737415389 no 2162 0.357885608164529 711 6287000
SGTC_3245 9134821 49.47 µM -0.364277372289931 0.363765862250893 no 2163 0.357825447545677 716 17014901
SGTC_1258 0671-0043 57.1 µM -0.365573520360388 0.363308490806769 no 2164 0.357341668523015 735 4298767
SGTC_2221 6807166 181.081 µM -0.366150108990494 0.363105092689719 no 2165 0.3571265340933 711 674925
SGTC_2138 5575593 77.673 µM -0.367215086789204 0.362729511340615 no 2166 0.356729293314032 732 762213
SGTC_363 0455-0021 3.06 µM -0.367828524258968 0.362513232769176 no 2167 0.356500549273922 710 4597466
SGTC_3028 9087778 49.47 µM -0.369804403814974 0.361816898898456 no 2168 0.355764116865842 678 17217395
SGTC_923 1900-2434 73.3 µM -0.370911021899247 0.361427107294572 no 2169 0.355351902764609 751 5910570
SGTC_1307 1187-1599 12.2 µM -0.371161523262828 0.361338891442141 no 2170 0.355258614728368 695 1538471
SGTC_914 3820-6779 408 µM -0.371300580398574 0.361289924655797 no 2171 0.355206832856898 694 2893481
SGTC_2025 5147754 141 µM -0.371350953022209 0.361272187288165 no 2172 0.355188075840321 703 315777 YLR208W SEC13
SGTC_2544 sphondin 68.51 µM -0.372555867768677 0.360847997856983 no 2173 0.354739512078364 683 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1185 1319-0113 81.3 µM -0.373098375603854 0.360657064171702 no 2174 0.354537613809121 736 4672763
SGTC_1131 3454-3128 32.3 µM -0.374779048984116 0.360065777859702 no 2175 0.353912398491277 667 710982
SGTC_1315 1237-0019 3.69 µM -0.375254308463397 0.359898635020765 no 2176 0.353735671939794 707 825140
SGTC_6 0844-0013 19.835 µM -0.376013982800076 0.359631522658406 no 2177 0.353453250399783 718 1584900
SGTC_982 1491-0518 27.5 µM -0.376918093255014 0.359313713849182 no 2178 0.353117237471497 693 3091256
SGTC_1424 4048-1941 275 µM -0.377261118946049 0.359193160464749 no 2179 0.352989781813664 726 X1424
SGTC_672 1441-0018 53.7 µM -0.38007024955706 0.358206444465093 no 2180 0.351946634528242 703 251141
SGTC_3114 9122766 49.47 µM -0.382137227773961 0.3574810156752 no 2181 0.351179789826512 699 17176985
SGTC_3045 9092950 49.47 µM -0.382443890916627 0.357373432644261 no 2182 0.351066069936731 724 44120432
SGTC_1437 4092-1038 11.6 µM -0.382466547316065 0.35736548481512 no 2183 0.351057668793316 714 3977136
SGTC_100 0086-0128 49.5915 µM -0.383253549748628 0.357089444028952 no 2184 0.350765888273337 753 93297
SGTC_2895 9054447 58.44 µM -0.384321632106175 0.356714934218962 no 2185 0.350370038373279 703 2697450
SGTC_2933 9026794 32.47 µM -0.384331654617305 0.356711420603327 no 2186 0.350366324625097 730 17586027
SGTC_2937 9044753 11.33 µM -0.384670653235335 0.356592584211174 no 2187 0.350240720270374 664 6465530 YGL099W LSG1
SGTC_1807 st050092 58.9 µM -0.385506972130062 0.356299471121647 no 2188 0.349930920948668 732 5008496
SGTC_2201 6605497 169.863 µM -0.385528704066713 0.356291855642096 no 2189 0.349922872073277 728 670741
SGTC_1727 st034309 9.9045 µM -0.39155042212163 0.354183894805581 no 2190 0.347695212985375 743 870305
SGTC_143 4032-1194 15.74 µM -0.392451583556063 0.353868816639361 no 2191 0.347362289243921 708 1806963
SGTC_748 act1.228 77.9 µM -0.392991308454069 0.353680157465575 no 2192 0.34716295043168 710 4421505 YNR035C ARC35
SGTC_2306 7482397 179.52 µM -0.394123202310749 0.35328462419732 no 2193 0.346745040784858 758 891448
SGTC_1953 st076800 12.1 µM -0.395213848350715 0.352903654574828 no 2194 0.346342536678325 707 297591
SGTC_2202 7226349 200 µM -0.396320390731279 0.352517282919025 no 2195 0.345934343280027 691 844334
SGTC_2106 5357045 167.29 µM -0.396617598725105 0.352413532634915 no 2196 0.345824736433441 715 668842
SGTC_810 3825-7150 143 µM -0.397144256103065 0.35222971242326 no 2197 0.345630543062084 696 22330411 YGL099W LSG1
SGTC_3018 9082602 49.47 µM -0.39851388466979 0.351751830096789 no 2198 0.345125712789311 726 17332089
SGTC_1181 1222-0449 220 µM -0.399824506583513 0.351294755204311 no 2199 0.344642889642902 732 658318
SGTC_2255 7941087 197.44 µM -0.400353087380527 0.351110475266213 no 2200 0.344448236035278 724 935561
SGTC_3033 9090887 49.47 µM -0.402375810702332 0.350405613736587 no 2201 0.343703734678269 714 19325384
SGTC_1117 retinoic acid 1.10837 µM -0.402551039910549 0.350344575541391 no 2202 0.34363926674513 737 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_627 1391-0720 175 µM -0.402591064709941 0.350330634106956 no 2203 0.34362454200638 726 997839
SGTC_2257 7960413 200 µM -0.402871921292525 0.350232811841069 no 2204 0.34352122424583 708 2974689 YIL048W NEO1
SGTC_783 0848-0141 92.7 µM -0.403768528820102 0.349920590213346 no 2205 0.343191470528683 709 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1489 4065-0444 182 µM -0.404206213526653 0.349768214060731 no 2206 0.343030542479568 724 2877968
SGTC_3023 9089636 49.47 µM -0.4043135121927 0.349730862648241 no 2207 0.342991095216581 734 17249241
SGTC_663 1486-0733 13.9 µM -0.404382158309688 0.349706967219987 no 2208 0.342965859067629 733 722445 YPR165W RHO1
SGTC_2952 9073731 13.78 µM -0.405740420809194 0.349234284230346 no 2209 0.342466669625908 730 16457353
SGTC_2815 7968870 71.43 µM -0.406769749683691 0.348876227649029 no 2210 0.342088553211252 739 2977326 YHR190W ERG9
SGTC_909 3448-9333 149 µM -0.408054303425418 0.348429578704217 no 2211 0.341616903872044 708 3344074
SGTC_2745 rifampicin 24.3 µM -0.409484590403107 0.34793250441106 no 2212 0.341092036528209 704 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2076 5212012 200 µM -0.409983784437021 0.347759078633839 no 2213 0.34090892136324 723 604802
SGTC_1993 st073995 70.8 µM -0.410122108792712 0.347711028787809 no 2214 0.340858187627555 709 3098394
SGTC_841 0251-0215 91.2 µM -0.410386989679118 0.347619023722374 no 2215 0.340761044317983 743 3888614
SGTC_2910 7948405 25.97 µM -0.410979489313383 0.347413254402506 no 2216 0.340543787238858 732 2971328
SGTC_2303 7774051 200 µM -0.413028295969573 0.346702070775082 no 2217 0.339792941290896 764 2953184
SGTC_1253 0550-0034 176 µM -0.413278594757373 0.346615223789388 no 2218 0.339701255360622 698 5969915
SGTC_2774 tamoxifen 10.92 µM -0.416380307154271 0.34553968266338 no 2219 0.338565868154747 722 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2405 ticlatone 3.52 µM -0.418816653998212 0.344695734854241 no 2220 0.337675066299215 720 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1132 3456-3614 2.5 µM -0.42048307707406 0.344118932260636 no 2221 0.337066294730929 740 3125502
SGTC_1754 st042065 16.137 µM -0.421353834112409 0.34381767935985 no 2222 0.33674836249676 737 1126236 YIL048W NEO1
SGTC_2701 st077767 14.721 µM -0.421953455444593 0.343610287998289 no 2223 0.336529495571184 734 5721188
SGTC_2451 5856223 45.7 µM -0.422160825466168 0.343538575763965 no 2224 0.336453816618056 718 2179896
SGTC_3052 9092717 49.47 µM -0.422286836329417 0.343495001721148 no 2225 0.336407832636718 750 25237534
SGTC_251 melphalan 456.522 µM -0.423133938746403 0.343202131169706 no 2226 0.3360987709127 730 460612 A DNA alkylator.
SGTC_3089 9117425 49.47 µM -0.423298976603307 0.34314508322726 no 2227 0.336038570436403 759 9401657
SGTC_595 3909-8003 73.7 µM -0.425216858064837 0.342482399639054 no 2228 0.335339298011657 748 699517
SGTC_3215 9129942 49.47 µM -0.425470994430091 0.342394624482547 no 2229 0.335246680917122 757 17682944
SGTC_480 am 92016 50 µM -0.426787186811511 0.341940166282422 no 2230 0.334767169984325 778 2129 K+ channel blocker.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.427033698839177 0.341855075424869 no 2231 0.334677391442848 779 65057 A dermal irritant. YDR527W RBA50
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.428263530726022 0.341430682956942 no 2232 0.334229633621859 755 688751
SGTC_3181 9108277 49.47 µM -0.428372840540221 0.341392971832551 no 2233 0.334189847449854 752 17097298
SGTC_1319 1306-0155 43.7 µM -0.42868280373958 0.341286045301183 no 2234 0.334077038351493 711 3122360
SGTC_2536 dehydroabietamide 32.04 µM -0.430271197632672 0.340738304708541 no 2235 0.333499188080401 727 3983547
SGTC_2719 novobiocin 32.65 µM -0.430710312801465 0.340586939722581 no 2236 0.333339509641316 741 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2094 5332512 191.667 µM -0.431129804378887 0.340442363051581 no 2237 0.333186995265321 760 755774
SGTC_451 chloral hydrate 100 µM -0.431385943736445 0.340354096821439 no 2238 0.333093884347296 764 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_308 4092-1169 104 µM -0.432426416593044 0.339995637366423 no 2239 0.332715760978638 735 2268590 YDL196W YDL196W
SGTC_3295 9122362 53.5725 µM -0.433287991836782 0.339698920409297 no 2240 0.332402780395293 759 4730473
SGTC_1965 Pectolinarigenin 58.4 µM -0.43360293215639 0.339590483232495 no 2241 0.33228840257993 733 5320438 An anti-inflammatory.
SGTC_2842 9000675 19.48 µM -0.433926954695969 0.339478932811176 no 2242 0.332170742648089 708 2989072
SGTC_2019 4016004 108 µM -0.43484441562477 0.339163157161602 no 2243 0.331837681543233 727 45595336
SGTC_2394 5221648 200 µM -0.43537439064475 0.338980799527752 no 2244 0.331645347968244 736 788586
SGTC_1508 1080-0625 72.9 µM -0.436262347511599 0.338675349480469 no 2245 0.331323198449011 736 767111
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.438659199684315 0.337851381611553 no 2246 0.330454247333673 757 165506
SGTC_2124 5246320 200 µM -0.440092708009367 0.337358954021914 no 2247 0.329934981541305 730 579342
SGTC_818 4072-2707 53.5 µM -0.441434694712568 0.336898217532697 no 2248 0.329449164791198 723 882871
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.442547033584436 0.33651651007094 no 2249 0.329046701603882 752 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2416 tofa 880 nM -0.443404811150444 0.336222272219069 no 2250 0.328736478283313 738 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1699 st031318 29.054 µM -0.443946815230746 0.336036403788821 no 2251 0.328540518221344 738 5340658
SGTC_1344 1488-0097 29.1 µM -0.444056951788299 0.335998639767091 no 2252 0.328500704418461 749 747966
SGTC_49 0717-0965 32.132 µM -0.444913794919515 0.335704898854855 no 2253 0.328191026533516 779 5889349 YGL099W LSG1
SGTC_2894 9048625 32.47 µM -0.446087726704064 0.335302617331753 no 2254 0.327766939012944 763 4092861
SGTC_513 4245-1575 41.7 µM -0.449128647139437 0.334261437218838 no 2255 0.326669428046 725 719745
SGTC_2924 9010168 62.78 µM -0.449357635887067 0.334183085287485 no 2256 0.326586843329733 727 2993929
SGTC_1390 3413-2614 145 µM -0.451307897844576 0.333516067043019 no 2257 0.325883826719118 767 3421432
SGTC_2930 9013230 14.89 µM -0.452099068108771 0.333245625033561 no 2258 0.32559880749695 738 2995857
SGTC_3144 9087057 49.47 µM -0.452404500382158 0.333141243738129 no 2259 0.325488802731347 786 17249618
SGTC_2298 7976326 193.81 µM -0.45297619119929 0.332945903485944 no 2260 0.325282942901997 737 2235818
SGTC_2799 7812892 81.82 µM -0.453023962091521 0.332929582766499 no 2261 0.325265743520274 765 20205235
SGTC_2397 5161689 200 µM -0.45336783668756 0.332812108833688 no 2262 0.325141946258015 758 2259942
SGTC_2698 st077697 67.5 µM -0.45564172512537 0.332035719916657 no 2263 0.324323816779195 744 3154499
SGTC_65 0798-0905 34.986 µM -0.455677063254359 0.332023659860834 no 2264 0.324311109039313 817 3602145
SGTC_2211 7117706 200 µM -0.456061617331952 0.331892432029988 no 2265 0.324172835007052 740 822771
SGTC_471 1-acyl-paf 4 µM -0.4578734926091 0.331274413156718 no 2266 0.323521665923098 723 16759367
SGTC_1079 idarubicin 2.36 µM -0.459512305289612 0.330715820277354 no 2267 0.322933158774376 763 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_31 0508-1974 57.237 µM -0.460906777200113 0.330240808115701 no 2268 0.322432744624257 723 6810525
SGTC_2050 5263056 171 µM -0.460931408100578 0.330232420314613 no 2269 0.322423908573473 739 763468 YGL055W OLE1
SGTC_2827 7993847 71.43 µM -0.46108231232564 0.330181033287688 no 2270 0.322369775617509 744 2985692
SGTC_2439 5492030 7.2 µM -0.461201826857919 0.330140337584902 no 2271 0.322326905568013 738 5722370
SGTC_871 0574-0004 149 µM -0.461349345330642 0.330090109076076 no 2272 0.32227399371969 750 9551173
SGTC_1731 st035964 63 µM -0.461457885336882 0.330053154286017 no 2273 0.322235064946635 767 6739575
SGTC_1531 st059297 52.4 µM -0.461597162842817 0.330005736679193 no 2274 0.322185114770722 734 7566702
SGTC_1152 3909-8331 15.9 µM -0.461844185643272 0.329921643455792 no 2275 0.322096530960133 736 16001939
SGTC_1087 pterostilbene 9.05 µM -0.461900641643389 0.329902425517175 no 2276 0.322076286929244 751 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1947 st076332 61.6 µM -0.463175809762388 0.329468470822945 no 2277 0.321619176996343 754 24208416
SGTC_1251 0490-5699 265 µM -0.463436738345453 0.329379702034408 no 2278 0.321525675087216 766 3883818
SGTC_554 4483-2211 187 µM -0.463816022094443 0.329250685565213 no 2279 0.321389781605673 736 747107
SGTC_324 1315-0088 19.6 µM -0.464203111267559 0.329119034979117 no 2280 0.321251116167686 762 6787421
SGTC_326 k292-0812 17.5 µM -0.464453681091267 0.329033826469994 no 2281 0.321161368803904 753 3579357
SGTC_862 0452-0056 10.2 µM -0.464681820629901 0.328956253305245 no 2282 0.321079664447628 748 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2376 9072922 81.32 µM -0.466132960058734 0.328463002071643 no 2283 0.320560166054004 760 17087968
SGTC_2242 6630449 61.2675 µM -0.46898329936634 0.327495024644376 no 2284 0.319540786723636 738 691249 YDR170C SEC7
SGTC_3026 9090633 49.47 µM -0.469013989895667 0.327484608409858 no 2285 0.319529818133803 746 25236842
SGTC_1797 st048695 56.8 µM -0.469233432823214 0.327410134331255 no 2286 0.319451395300624 781 592262 YIL048W NEO1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.47031681918361 0.327042557655127 no 2287 0.319064341374353 741 16623 A steroid.
SGTC_3198 9112019 49.47 µM -0.470406216676051 0.327012233918509 no 2288 0.319032411753869 798 45595555
SGTC_1026 k007-1105 30.6 µM -0.47157731228555 0.326615102424742 no 2289 0.318614261925562 736 7066794
SGTC_3004 9076122 71.4286 µM -0.475657725253517 0.325232925809218 no 2290 0.317159121581226 770 44782551
SGTC_2064 5220758 200 µM -0.477142007790467 0.324730742621089 no 2291 0.316630501614761 742 788518
SGTC_2123 5259487 200 µM -0.477479632593981 0.324616557103121 no 2292 0.31651031040567 746 2173474
SGTC_1976 st070609 63.5 µM -0.47783539497567 0.324496255247137 no 2293 0.3163836833555 743 682556
SGTC_2336 9001819 198.65 µM -0.478873102242047 0.324145456824126 no 2294 0.316014453617843 772 2989602
SGTC_3297 9117502 71.43 µM -0.479085680911156 0.324073613552035 no 2295 0.315938837991159 744 7453720
SGTC_1120 ficusin 1.78878 µM -0.480331504240049 0.323652705791206 no 2296 0.315495845354313 770 6199 A DNA cross-linker.
SGTC_966 1300-0360 30.2 µM -0.482854710205379 0.322800919025602 no 2297 0.314599450606255 768 70588
SGTC_191 3914-0123 66.505 µM -0.483503806750412 0.322581946292372 no 2298 0.314369028742117 770 3144412
SGTC_1575 cyproterone acetate 48 µM -0.484030178640304 0.322404419893319 no 2299 0.314182225817092 779 9880 An androgen receptor antagonist and liver toxin.
SGTC_2004 4023728 41.89 µM -0.485111297381969 0.322039924259943 no 2300 0.313798699329927 759 360084 YDR527W RBA50
SGTC_2314 7727897 200 µM -0.485520927401323 0.321901863525629 no 2301 0.313653435739451 732 900724
SGTC_2070 5230947 200 µM -0.485915812930115 0.321768795508387 no 2302 0.313513428208083 785 2835538
SGTC_1817 st052116 64.4 µM -0.48748652554692 0.32123972520916 no 2303 0.312956794690512 750 4361398
SGTC_2060 5238662 140 µM -0.489190709320924 0.320666107298251 no 2304 0.312353343221044 770 790130
SGTC_2602 kawain 100 µM -0.489357740089866 0.320609908763265 no 2305 0.312294224663767 760 5369129
SGTC_2514 salinomycin 42.74 µM -0.490098438076403 0.320360745907696 no 2306 0.312032121648247 758 23682228 A polyether potassium ionophore.
SGTC_1194 1488-0194 225 µM -0.491270270504378 0.319966719437709 no 2307 0.311617651963097 745 1391452
SGTC_1223 0764-0573 147 µM -0.492037683603637 0.319708788189037 no 2308 0.311346352055535 754 1609797
SGTC_2433 5607874 27.82 µM -0.496599214269332 0.318177438135782 no 2309 0.309735853671035 755 2252428
SGTC_3247 9135149 49.47 µM -0.496653207361669 0.318159330661538 no 2310 0.309716812590305 763 8934436 YOR116C RPO31
SGTC_1002 4049-0206 172 µM -0.499861144765883 0.317084277145185 no 2311 0.308586426536265 755 4662749
SGTC_1211 1056-0033 32.3 µM -0.504495729051319 0.315533845982421 no 2312 0.306956531348182 777 6741922
SGTC_3296 9122258 64.045 µM -0.50605802623926 0.315011931883497 no 2313 0.306407957666919 772 4730474
SGTC_944 3370-0224 231 µM -0.50694164014918 0.314716907767134 no 2314 0.306097883779421 743 4580514
SGTC_301 4119-0100 24.5 µM -0.507593021034704 0.314499498119851 no 2315 0.305869392983281 773 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3042 9091578 49.47 µM -0.507871635555033 0.314406525332974 no 2316 0.305771683894253 749 25236497
SGTC_1688 st021091 57.6 µM -0.508398713260435 0.314230673364519 no 2317 0.305586877498673 782 3656366
SGTC_406 estrone 100 µM -0.509863120926305 0.31374231598606 no 2318 0.305073680198845 771 5870 A steroid.
SGTC_2798 7813637 45.45 µM -0.51408729247008 0.312335449588226 no 2319 0.303595480734019 790 956368
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.51478546138821 0.312103185924318 no 2320 0.303351472947819 752 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_980 1473-0395 201 µM -0.515607749763096 0.311829726528446 no 2321 0.303064198268326 777 768876
SGTC_1015 4130-4525 82 µM -0.516627003647473 0.311490908429406 no 2322 0.302708280749798 759 1363237
SGTC_368 fentichlor 4.58 µM -0.518420031527794 0.310895261501927 no 2323 0.302082620747577 799 7329 A pesticide.
SGTC_2458 5808907 16.39 µM -0.518541842250003 0.310854813716592 no 2324 0.302040137126805 782 2731747
SGTC_2575 plumbagin 510 nM -0.518737586624435 0.31078982072439 no 2325 0.301971873471973 783 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_905 2-aminofluorene 215 µM -0.518901437740231 0.310735421787479 no 2326 0.301914737562419 760 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2223 6903751 107.57 µM -0.519195681228083 0.310637742677736 no 2327 0.301812145211741 773 5598863
SGTC_2460 5552655 174.22 µM -0.519939731973065 0.310390801992594 no 2328 0.301552790832212 772 5401989
SGTC_1748 st037455 53.6035 µM -0.520991406335299 0.310041910811953 no 2329 0.301186378960721 788 580690
SGTC_1970 st070122 35.8 µM -0.521234711541373 0.309961219063805 no 2330 0.301101638032218 787 102928
SGTC_970 1315-0089 19.5 µM -0.523902676030312 0.30907699444347 no 2331 0.30017311672522 764 6811083 YLR033W RSC58
SGTC_697 0508-1955 564 µM -0.524082649015804 0.309017386996923 no 2332 0.300110528067841 783 6243113
SGTC_1402 3909-7673 35.9 µM -0.524853374712028 0.308762177851925 no 2333 0.299842561926364 741 5328014
SGTC_1791 st048313 56.1 µM -0.525054229623986 0.308695684252109 no 2334 0.299772746427301 760 1204976
SGTC_773 4358-1457 44.6 µM -0.525712473381522 0.308477814716317 no 2335 0.2995439979756 799 1186886
SGTC_1113 artemisinin 1.17947 µM -0.52657733467771 0.308191660142131 no 2336 0.299243567502321 776 2240 An anti-malaria and mitochondrial poison.
SGTC_3170 9103054 49.47 µM -0.526854045317254 0.308100130158617 no 2337 0.299147474250507 786 16432970
SGTC_3242 9133940 49.47 µM -0.527226324089573 0.307977007101312 no 2338 0.299018215172616 786 17248444
SGTC_3346 9158254 43.5805 µM -0.527584105608815 0.307858699058202 no 2339 0.29889401359753 793 17639500
SGTC_2593 nobiletin 86.24 µM -0.52793213289383 0.30774363562077 no 2340 0.298773220634728 755 72344 An anti-infammatory.
SGTC_379 3970-0972 5.9 µM -0.528641760640205 0.30750907981992 no 2341 0.29852699251203 762 2898042 YBL034C STU1
SGTC_2640 pentamidine 10.38 µM -0.528885566769319 0.307428511862413 no 2342 0.298442417461203 783 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1089 terbinafine 2.25 µM -0.532184228827396 0.306339353408201 no 2343 0.297299202480823 766 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_282 k297-0036 65.7 µM -0.533079894302653 0.306043915494637 no 2344 0.296989138093764 781 5061378
SGTC_3095 9117207 49.47 µM -0.53340578957952 0.305936449255015 no 2345 0.296876355322256 766 17015229
SGTC_659 k018-0002 107 µM -0.533503113285948 0.305904359323044 no 2346 0.29684267825049 769 6797879 YHR007C ERG11
SGTC_770 0389-1121 67.2 µM -0.534756337373852 0.305491274835743 no 2347 0.296409179498069 755 6753108
SGTC_2041 5107442 45.335 µM -0.535555298355933 0.305228052530545 no 2348 0.296132965012856 779 793005
SGTC_3077 9117319 49.47 µM -0.535848473727686 0.305131489460574 no 2349 0.296031638897794 796 17154678
SGTC_533 1222-0222 6.71 µM -0.536410262716794 0.304946491119503 no 2350 0.295837520082249 791 3982874
SGTC_1682 st012968 530 nM -0.537951521261962 0.304439207374996 no 2351 0.29530525888571 753 24207270
SGTC_2350 9023895 38.85 µM -0.538425272417307 0.304283354293601 no 2352 0.295141741342905 758 2997209
SGTC_852 0418-0143 439 µM -0.538570084499757 0.304235721587251 no 2353 0.295091767061054 774 5369229
SGTC_2044 5102272 200 µM -0.539187929186711 0.30403253267559 no 2354 0.294878594224953 765 592666
SGTC_1660 st012960 28.1 µM -0.539274027768625 0.304004222470518 no 2355 0.294848893561514 794 24207266
SGTC_2946 9065502 71.43 µM -0.541175054399377 0.303379442721417 no 2356 0.294193464921413 759 16489101
SGTC_825 1988-2224 89.6 µM -0.541314440752918 0.303333655442616 no 2357 0.294145434330091 764 1180859
SGTC_2301 7769476 200 µM -0.542737424366333 0.302866393769615 no 2358 0.293655301501105 775 977820
SGTC_2880 9042983 58.44 µM -0.543147480785494 0.302731804373791 no 2359 0.293514131765305 798 6464714
SGTC_160 3453-0671 289.699 µM -0.543594426615224 0.302585137596755 no 2360 0.293360297955091 805 5322268
SGTC_2606 farnesol 9.78 µM -0.544112473408889 0.302415178659193 no 2361 0.293182038741909 793 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.544805278814651 0.302187952478579 no 2362 0.292943723848951 786 5282362
SGTC_821 1114-0266 29.2 µM -0.545492823636542 0.301962527454292 no 2363 0.292707307431279 770 3123235
SGTC_2646 retinol 96.75 µM -0.54577527915481 0.301869940781518 no 2364 0.292610209090619 785 445354 A vitamin A analog and teratogen.
SGTC_82 0054-0107 293.755 µM -0.545814473613684 0.30185709415755 no 2365 0.292596736587197 780 3104697
SGTC_2898 9056270 58.44 µM -0.547162604917552 0.30141537175473 no 2366 0.292133512352491 752 19154699
SGTC_1587 estradiol valerate 56.1 µM -0.548376730625503 0.301017806196465 no 2367 0.291716625380717 786 13791 A steroid.
SGTC_3000 9075062 71.4286 µM -0.548844233304039 0.300864785466875 no 2368 0.29155617579137 780 17057871
SGTC_2204 7233102 200 µM -0.548951117943441 0.300829805428733 no 2369 0.291519498153253 773 2172480
SGTC_2730 imipramine 71.33 µM -0.549804016484896 0.300550743856349 no 2370 0.291226901752623 761 3696 A tricyclic antidepressant.
SGTC_3002 9075603 71.4286 µM -0.549862600011165 0.300531580086741 no 2371 0.291206809050541 778 20105405
SGTC_2543 pimpinellin 60.67 µM -0.551604178800485 0.299962129246536 no 2372 0.29060978638605 769 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_384 k007-0144 5.16 µM -0.552456722682653 0.299683547766848 no 2373 0.290317738635265 774 6824886
SGTC_2147 5545932 89.7195 µM -0.552727244533812 0.299595175202191 no 2374 0.290225097303433 799 797404
SGTC_1695 st026914 34.495 µM -0.553399531414536 0.299375607441215 no 2375 0.289994929861276 776 3289191
SGTC_269 exalamide 29 µM -0.557814082849266 0.297935638946707 no 2376 0.288485672566603 768 3316 A derivative of salicylamide.
SGTC_263 alizarin 107.927 µM -0.558845380176201 0.297599698862963 no 2377 0.28813362432327 797 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2499 avocadenofuran 51.48 µM -0.559803971397011 0.297287597568869 no 2378 0.287806577247757 791 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3274 9138298 49.47 µM -0.559880319853314 0.297262746218149 no 2379 0.287780536626746 783 17015756
SGTC_1224 0823-0416 294 µM -0.56273143255555 0.296335392215642 no 2380 0.286808888518479 789 3598164
SGTC_25 0118-0223 35.662 µM -0.562918580109763 0.296274566950407 no 2381 0.286745163780558 793 5333628
SGTC_1217 1183-1422 255 µM -0.563260548312205 0.296163437855939 no 2382 0.286628739129441 771 2849664
SGTC_432 NS 1619 61.3 µM -0.563282605442782 0.296156270626936 no 2383 0.286621230447344 762 4552 A K+/calcium channel activator.
SGTC_2811 7967822 32.47 µM -0.564279923708708 0.295832285888369 no 2384 0.286281821157432 766 2232244
SGTC_2591 skatole 100 µM -0.564707844645646 0.295693323170983 no 2385 0.286136248803529 799 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1706 st031321 9.9705 µM -0.564751519613257 0.295679141882706 no 2386 0.286121393205375 771 6103185
SGTC_3331 9141060 1.957 µM -0.564843102455025 0.295649405893827 no 2387 0.286090243418527 772 4906567 YPR165W RHO1
SGTC_941 3237-0776 460 µM -0.565801646575302 0.29533825917899 no 2388 0.285764313514751 791 760008
SGTC_152 4469-0003 551.229 µM -0.56603552709629 0.29526236363191 no 2389 0.285684814873314 777 697280
SGTC_1933 st074711 15.9 µM -0.566285476743805 0.29518126348735 no 2390 0.285599865786727 802 17250958
SGTC_2751 anetholtrithion 17.25 µM -0.567025670959346 0.294941155860956 no 2391 0.285348370364673 784 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3356 9151811 4.48 µM -0.567881113863868 0.294663775493049 no 2392 0.285057848417921 804 1859254 YPR165W RHO1
SGTC_250 brefeldin a 552.239 µM -0.569384505564663 0.294176587222848 no 2393 0.284547614779499 774 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_497 capsazepine 133 µM -0.569876102388677 0.294017361417272 no 2394 0.284380867222243 762 2733484 A calcium channel blocker.
SGTC_2853 9015042 58.44 µM -0.57121964089567 0.293582399242698 no 2395 0.283925383004228 777 6457456
SGTC_887 0885-0007 9.62 µM -0.571337115084387 0.293544381878349 no 2396 0.283885573701861 789 5719458
SGTC_1215 3852-0577 11.2 µM -0.573227731887507 0.292932848389691 no 2397 0.283245254896187 769 2884876
SGTC_1803 st050068 52.4 µM -0.573612777338654 0.292808375195148 no 2398 0.28311493170508 790 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1643 st009866 20.2 µM -0.57413248438038 0.29264040905565 no 2399 0.282939076346212 780 3156273 YOR207C RET1
SGTC_1108 betulinic acid 729.144 nM -0.57515608461269 0.292309718679001 no 2400 0.282592870080212 760 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_23 0213-0011 39.996 µM -0.575212238105866 0.292291582427378 no 2401 0.282573883509061 803 627608
SGTC_1607 st000305 50.6 µM -0.578113112212023 0.291355381350716 no 2402 0.281593877504471 807 5457690
SGTC_1306 1185-0270 9.02 µM -0.582106623714228 0.290068846654378 no 2403 0.28024743192514 799 1548076
SGTC_1284 0929-0043 16 µM -0.58230540637335 0.290004877207422 no 2404 0.280180492265823 788 1239883
SGTC_811 0416-0114 265 µM -0.582810370131313 0.289842406601108 no 2405 0.280010481583294 795 6612453
SGTC_501 nsc-95397 161 µM -0.58283742448779 0.289833703146542 no 2406 0.280001374361849 794 262093
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.584672012895643 0.289243797677373 no 2407 0.27938413800616 803 689007
SGTC_2097 5376186 200 µM -0.584862219891488 0.289182669588349 no 2408 0.279320181829665 766 742755
SGTC_3102 9121669 49.47 µM -0.585529670051267 0.288968214750482 no 2409 0.279095811256803 799 41905072
SGTC_2634 4'-methoxyflavone 100 µM -0.587380235852532 0.288374011027357 no 2410 0.278474182303219 774 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_485 niflumic acid 177 µM -0.588903944798656 0.287885191582488 no 2411 0.27796285567402 790 4488 A COX2 inhibitor.
SGTC_2057 5236571 38.335 µM -0.590230290388758 0.287460006876223 no 2412 0.27751813362027 782 54684039 YBR257W POP4
SGTC_2142 5622915 118.518 µM -0.590709767446115 0.287306374720092 no 2413 0.277357451166715 778 5322196
SGTC_3013 9080133 71.4286 µM -0.590736453310043 0.287297825281794 no 2414 0.277348509530856 789 17050193
SGTC_2436 5633522 8.09 µM -0.592723108312524 0.286661692388796 no 2415 0.276683236922975 800 5724242
SGTC_416 estradiol valerate 100 µM -0.592967926449733 0.286583347135995 no 2416 0.276601308645529 803 13791 A steroid.
SGTC_2252 omeprazole 400 µM -0.594936062540566 0.28595388517023 no 2417 0.275943105178773 777 4594 A proton pump inhibitor.
SGTC_2907 7721985 69.9 µM -0.595096950913835 0.285902457884948 no 2418 0.275889333337419 785 3267881
SGTC_644 1498-1197 63.3 µM -0.597009616419757 0.285291419586757 no 2419 0.275250480126551 793 6741615
SGTC_1343 1487-0095 224 µM -0.598412624603536 0.284843597186065 no 2420 0.274782322037765 818 4560101 YGL055W OLE1
SGTC_313 3474-0040 5.03 µM -0.599132954228983 0.284613807487663 no 2421 0.274542113861944 794 1043375 YIL048W NEO1
SGTC_1623 st003709 20.3 µM -0.599285113934486 0.284565278906667 no 2422 0.274491386451914 785 16192618
SGTC_853 0419-0306 21 µM -0.599937800180448 0.284357161295432 no 2423 0.274273844646991 800 762713
SGTC_2245 6637752 200 µM -0.600250516443987 0.284257473374098 no 2424 0.274169645781869 778 681890
SGTC_2335 9018011 154.17 µM -0.600721112592975 0.28410748788182 no 2425 0.274012877289337 775 6458208
SGTC_2254 7938975 95.19 µM -0.601355663899775 0.283905307565028 no 2426 0.273801560996412 820 2969277
SGTC_212 3807-4682 38.772 µM -0.601884033078282 0.283737011486071 no 2427 0.273625666655432 795 3125501 YBL034C STU1
SGTC_1119 parthenolide 318.541 nM -0.603231857187742 0.283307919239155 no 2428 0.273177228768907 825 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.604436872456097 0.282924555178333 no 2429 0.272776613725401 815 61125 An anti-inflammatory.
SGTC_2626 ethyl orsellinate 100 µM -0.60488048468977 0.282783486952747 no 2430 0.272629205432988 820 75653 A natural product.
SGTC_397 arbidol 50 µM -0.605442189786423 0.282604913814666 no 2431 0.272442612706304 793 131410 A RNA synthesis inhibitor.
SGTC_1719 st032227 49.2 µM -0.606113256989559 0.282391644170413 no 2432 0.272219774179194 799 3125804
SGTC_2974 9094440 9.66 µM -0.606680760712393 0.282211348131847 no 2433 0.272031396269798 777 25236134
SGTC_1911 st060208 74.3 µM -0.608211473573283 0.281725316816221 no 2434 0.271523612939921 816 688783
SGTC_1155 4088-0394 48.2 µM -0.609679190613743 0.281259667189897 no 2435 0.271037170957025 804 2326248
SGTC_3257 9139206 32.98 µM -0.611316752236491 0.280740571458369 no 2436 0.270494951344159 798 4910041
SGTC_3096 9117468 49.47 µM -0.612661763779957 0.280314558949441 no 2437 0.270050004925151 808 41316311
SGTC_646 4092-0839 27.3 µM -0.61429192003909 0.279798651120393 no 2438 0.269511220448224 812 877796
SGTC_760 0568-0725 82.9 µM -0.616936965449593 0.278962535011015 no 2439 0.268638151765354 814 3916171
SGTC_1317 1273-0028 910 nM -0.617732669963227 0.278711245640955 no 2440 0.268375786358487 805 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1552 6-methylflavone 10.6 µM -0.61832585050516 0.278523986564266 no 2441 0.268180282486979 817 689013
SGTC_345 1362-0200 395 µM -0.622297193183863 0.277271868497489 no 2442 0.266873233238889 808 1419823
SGTC_1482 3346-2049 8.48 µM -0.623580898778735 0.276867720680998 no 2443 0.266451429105353 786 3826804
SGTC_1742 st038235 28.8875 µM -0.623965852035025 0.276746582463573 no 2444 0.266325005683278 828 564103 YBR002C RER2
SGTC_1066 ketoconazole 628 nM -0.625257193688223 0.276340409047147 no 2445 0.265901134902993 822 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1239 0337-0584 35.4 µM -0.6258795750012 0.27614475221986 no 2446 0.265696966225326 814 914301 YML130C ERO1
SGTC_3328 9140624 29.0385 µM -0.626693744063046 0.27588890614635 no 2447 0.265430002711379 815 4904392
SGTC_2711 st079103 59.1 µM -0.626894136675904 0.27582595224375 no 2448 0.265364315474008 802 54693780
SGTC_2117 5521686 200 µM -0.632065605766606 0.274203766592018 no 2449 0.26367200431426 801 803312
SGTC_656 4090-1979 187 µM -0.633030628348656 0.273901580950175 no 2450 0.263356821010752 805 22330961
SGTC_1471 k673-0312 37 µM -0.633342442507383 0.27380397516298 no 2451 0.263255021404599 806 24099884
SGTC_1749 st037932 54.2 µM -0.634443969412234 0.273459306906291 no 2452 0.262895561108209 829 594497
SGTC_961 1252-1571 372 µM -0.638156751173285 0.272299160297613 no 2453 0.261685823543753 828 6813498
SGTC_2022 5136654 200 µM -0.638177893493822 0.272292560887739 no 2454 0.261678942919065 825 1713771
SGTC_495 decylubiquinone 155 µM -0.643117344641734 0.270752931505344 no 2455 0.260073980401286 828 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1222 0366-0074 1.18 µM -0.643280569505461 0.270702128514711 no 2456 0.260021030945233 816 286520
SGTC_2955 9076254 12.21 µM -0.644679154742594 0.270267020488573 no 2457 0.259567563787475 800 16459619
SGTC_2361 9034121 116 µM -0.645460906789085 0.2700239653145 no 2458 0.259314272187577 845 6496917
SGTC_1740 st038286 13.222 µM -0.645865943287362 0.26989807811097 no 2459 0.259183088568274 801 716786
SGTC_3021 9087658 49.47 µM -0.646276838726678 0.269770399947513 no 2460 0.259050042410608 807 25237042
SGTC_1758 st042942 75.2445 µM -0.646626862295967 0.269661660454634 no 2461 0.258936734163052 814 669317
SGTC_2188 6126565 140.678 µM -0.647080219172286 0.269520851734747 no 2462 0.258790013381986 809 874518
SGTC_2195 6536160 144.242 µM -0.647407250098122 0.269419301643185 no 2463 0.258684202435392 799 3834386
SGTC_2720 fluspirilene 36.88 µM -0.64742173746139 0.269414803450995 no 2464 0.258679515563087 820 3396 An atypical antipsychotic.
SGTC_1453 4237-0541 195 µM -0.647791567312696 0.269299987455114 no 2465 0.258559885124316 798 739892
SGTC_2629 bisabolol 100 µM -0.649076753536254 0.268901184232747 no 2466 0.258144383341693 841 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_629 3448-6466 76.7 µM -0.649831019555332 0.268667267821091 no 2467 0.257900689815908 827 573744
SGTC_845 0330-0138 4.51 µM -0.651605005890836 0.268117514428261 no 2468 0.257328008791467 819 9039800
SGTC_426 0988-0037 14.6 µM -0.652056994778587 0.267977534899517 no 2469 0.257182202753657 821 5383008
SGTC_61 0978-8327 98.565 µM -0.65231411245858 0.267897922791121 no 2470 0.257099278934409 820 6150059 YHR072W ERG7
SGTC_2645 abamectin 100 µM -0.652649925647972 0.267793961901249 no 2471 0.256990995726225 806 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1873 rapamycin 2 nM -0.652692320496734 0.267780838768936 no 2472 0.256977327163113 798 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3214 9129694 49.47 µM -0.653512191858205 0.267527115062831 no 2473 0.2567130660646 831 17158655
SGTC_3194 9111903 49.47 µM -0.653655102477606 0.267482901251155 no 2474 0.256667017570071 832 17087251
SGTC_2912 7964298 10.93 µM -0.655150688903671 0.267020416601096 no 2475 0.256185369594678 814 2975850
SGTC_847 0342-0274 5.54 µM -0.655705132289144 0.266849067079107 no 2476 0.256006933006833 820 18097
SGTC_1995 st072814 61.1 µM -0.656193853886362 0.266698074815317 no 2477 0.255849701452229 811 5769371
SGTC_2462 5162487 171.77 µM -0.657013697627143 0.266444878223748 no 2478 0.255586054487404 816 2259986
SGTC_2940 9060638 45.86 µM -0.657014182097297 0.266444728638278 no 2479 0.255585898732501 810 4027022
SGTC_1900 st060200 72.8 µM -0.658311535751996 0.266044308920438 no 2480 0.255168983455933 813 688945
SGTC_70 0141-0289 43.283 µM -0.659644438687183 0.2656332348186 no 2481 0.254741014811679 813 352408
SGTC_2074 5212007 75.395 µM -0.661815425233824 0.264964381705697 no 2482 0.254044759578352 807 758611
SGTC_1686 st019653 115.5 µM -0.66421334063932 0.264226610667519 no 2483 0.253276888114475 845 97252
SGTC_2515 chrysin 20.77 µM -0.664435335023021 0.264158362195114 no 2484 0.253205861821247 809 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_319 1348-1596 45.5 µM -0.66508697241014 0.263958079021177 no 2485 0.252997433330231 827 5380505
SGTC_2329 6138490 200 µM -0.665992414034237 0.26367991671324 no 2486 0.25270797460529 827 720019
SGTC_712 r015-0009 80.6 µM -0.666485840226581 0.263528393358731 no 2487 0.252550305674171 822 6813872 YLR060W FRS1
SGTC_3202 9113761 49.47 µM -0.668011086434594 0.263060295589326 no 2488 0.25206325786892 823 4798415
SGTC_2763 lisinopril 49.32 µM -0.668699668074168 0.262849109320266 no 2489 0.251843539653176 827 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1829 berberine 14.4 µM -0.670907402517337 0.262172587773703 no 2490 0.251139760153273 822 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3208 9114115 49.47 µM -0.672194301675965 0.261778652083471 no 2491 0.250730004093635 826 650895
SGTC_1640 st009078 66.4 µM -0.67271857913186 0.261618251389808 no 2492 0.250563172702483 823 690618
SGTC_933 2914-0560 114 µM -0.67313850039605 0.261489814466739 no 2493 0.250429591135427 806 463887
SGTC_2913 7966556 36.57 µM -0.674299224435573 0.261134964445576 no 2494 0.250060548513207 813 2976516
SGTC_499 genistein 192 µM -0.674405097375692 0.261102609887532 no 2495 0.250026901451094 845 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_312 4092-0653 6.84 µM -0.677154108481102 0.260263239556487 no 2496 0.249154090669079 829 1148278
SGTC_790 1575-0012 79.1 µM -0.677936071660739 0.260024732795633 no 2497 0.248906113809653 833 378741 YLR208W SEC13
SGTC_2874 9043904 71.43 µM -0.680071976105969 0.25937383495075 no 2498 0.24822944388655 830 4463428
SGTC_3231 9132313 49.47 µM -0.680987514274346 0.259095090813698 no 2499 0.247939695435748 826 4905967
SGTC_2492 derrusnin 100 µM -0.681535669701555 0.25892827393957 no 2500 0.247766302269236 845 1715307 Part of coumarin class of compounds.
SGTC_1975 st070967 30.8 µM -0.682100561092749 0.258756422058209 no 2501 0.247587682924971 831 261391
SGTC_2431 5490079 200 µM -0.68281904897349 0.258537928205753 no 2502 0.247360595607838 861 5722345
SGTC_2271 7849410 118.62 µM -0.684212824277238 0.25811435047966 no 2503 0.246920392690638 844 972430
SGTC_869 0564-0080 44.1 µM -0.684424843443636 0.258049947970628 no 2504 0.246853466390854 818 6843321
SGTC_3056 9094900 49.47 µM -0.684939152787339 0.257893757049326 no 2505 0.246691159056745 832 25236784
SGTC_889 0919-1524 82.7 µM -0.685132529407896 0.257835043075756 no 2506 0.246630147451047 833 3905452
SGTC_1653 st012112 65 µM -0.686959487653404 0.257280675454944 no 2507 0.246054129092736 835 720429
SGTC_995 3931-2021 34.6 µM -0.687449156399862 0.257132196950004 no 2508 0.245899865048638 834 730143
SGTC_3291 9121177 71.43 µM -0.687871163539575 0.25700427071321 no 2509 0.245766958605224 828 17015612
SGTC_2354 9060492 162 µM -0.688556629264108 0.256796550855119 no 2510 0.245551161040052 833 6471895
SGTC_465 cgp-37157 41 µM -0.689388115513104 0.256544699062002 no 2511 0.245289530135934 807 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_422 cantharidin 155 µM -0.691553912759041 0.255889297639466 no 2512 0.244608756351561 836 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2442 5158906 48.48 µM -0.691588128275176 0.255878950547489 no 2513 0.244598009579266 824 1893835
SGTC_340 k038-0059 454 µM -0.691803697693176 0.255813765361872 no 2514 0.244530307097961 831 23733424
SGTC_1488 4013-0813 75.9 µM -0.692676365113595 0.255549971500527 no 2515 0.244256337308938 825 2910057
SGTC_1583 clindamycin 39.6 µM -0.697534977811719 0.254083890027432 no 2516 0.242734028774568 844 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1878 temozolomide 1 mM -0.697837993826359 0.253992601636399 no 2517 0.242639257731826 822 5394 DNA alkylating agent.
SGTC_3341 9147222 25.867 µM -0.69881184929135 0.253699328770549 no 2518 0.242334811194055 835 1939759
SGTC_476 mead acid 10 µM -0.699630644522812 0.253452889383052 no 2519 0.242078999831865 852 5312531 An omega 9 fatty acid.
SGTC_812 4251-0442 148 µM -0.7006299412034 0.253152293563422 no 2520 0.241766993979812 847 5723007
SGTC_989 1501-0895 10.3 µM -0.70082590664703 0.253093367709554 no 2521 0.24170583418721 833 2830112
SGTC_1710 st031758 61.5 µM -0.702469097326892 0.252599552320583 no 2522 0.241193333542814 834 5394341
SGTC_1813 st051246 8.6015 µM -0.70418677594577 0.252083894737166 no 2523 0.240658232641616 821 5291959
SGTC_283 0987-0079 11.7 µM -0.7051745531475 0.251787609697289 no 2524 0.240350807629389 822 411556
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.705861000961469 0.251581817130566 no 2525 0.240137291154626 832 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1610 st001799 48.1 µM -0.708347916433568 0.250837000864112 no 2526 0.239364613902132 842 621897
SGTC_1734 st037168 69.4 µM -0.708649005915591 0.25074690565636 no 2527 0.239271158538012 838 708907
SGTC_3324 9138759 60.749 µM -0.710455329393505 0.250206758237587 no 2528 0.238710911351499 852 45595710
SGTC_974 1326-0144 138 µM -0.711962355449114 0.249756582755869 no 2529 0.238244043661037 847 5411856
SGTC_3310 9130229 44.1445 µM -0.711996458794013 0.249746400459074 no 2530 0.238233484439061 846 7761258
SGTC_3047 9092122 49.47 µM -0.716456183994283 0.248416753687211 no 2531 0.236854856728766 844 17173831
SGTC_543 3844-1095 191 µM -0.718216108834272 0.247893080221123 no 2532 0.236312023462097 851 4230703
SGTC_3087 9117406 49.47 µM -0.718799190703513 0.247719711651112 no 2533 0.236132328197351 828 42546093
SGTC_1902 st060212 70.5 µM -0.719979190005726 0.247369058955037 no 2534 0.235768904210212 824 688944
SGTC_968 1309-0633 340 µM -0.720373953986822 0.24725180877126 no 2535 0.235647391072489 841 3761976
SGTC_2438 5259590 200 µM -0.721439696745488 0.246935417370165 no 2536 0.235319515108049 832 1201127
SGTC_1291 0993-0025 5.79 µM -0.721880066069217 0.246804746419905 no 2537 0.235184108966548 840 4353356
SGTC_1001 4048-4355 44.4 µM -0.722681819803486 0.246566936822596 no 2538 0.234937693729128 845 21824233
SGTC_1606 st000094 49.2 µM -0.722848209163859 0.246517599164432 no 2539 0.234886572624444 823 1242210
SGTC_986 1493-0483 84 µM -0.723358259017892 0.246366392497715 no 2540 0.234729904330636 847 40079
SGTC_1691 st019933 84.6 µM -0.723682316267691 0.246270350040148 no 2541 0.234630396050466 861 6176082
SGTC_639 0833-0042 114 µM -0.724338424550528 0.246075957447096 no 2542 0.234428996290058 864 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1832 st054113 55 µM -0.724819138177832 0.245933583266758 no 2543 0.234281496613877 834 1251267
SGTC_3201 9113999 49.47 µM -0.725308004747739 0.245788839755924 no 2544 0.234131548030206 847 16649224
SGTC_503 tyrphostin 8 294 µM -0.725330974244505 0.245782040077198 no 2545 0.234124503972421 870 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2700 st077718 96.8 µM -0.726772670010062 0.24535545587292 no 2546 0.233682613913205 844 904970
SGTC_2122 5258151 111.688 µM -0.726979109542768 0.245294404945665 no 2547 0.233619376586699 840 2173356
SGTC_1784 st039334 36.3 µM -0.72763255201936 0.245101214460761 no 2548 0.233419274218163 872 3496984
SGTC_3071 9117417 49.47 µM -0.727712699444115 0.245077524483612 no 2549 0.23339473738238 850 45595590 YGL055W OLE1
SGTC_102 gallobenzophenone 83.616 µM -0.729188981516849 0.244641385357932 no 2550 0.232943035141443 829 70837
SGTC_399 oxolinic acid 75 µM -0.73082513743762 0.244158503318732 no 2551 0.232442983648019 830 4628 A DNA gyrase inhibitor.
SGTC_3342 9147791 14.508 µM -0.731097952824174 0.244078036778958 no 2552 0.232359662332766 839 1838168
SGTC_1903 st060211 78.3 µM -0.732783028015628 0.243581343220811 no 2553 0.231845387181019 825 688960
SGTC_581 0958-0271 211 µM -0.732859813512111 0.24355872290299 no 2554 0.231821967807131 839 4591145
SGTC_2078 5212016 200 µM -0.733238365257915 0.24344722154381 no 2555 0.23170652978781 840 1899708
SGTC_877 0771-0151 33.1 µM -0.734704680001863 0.243015583052493 no 2556 0.23125968474122 845 6166523
SGTC_1831 st055328 12 µM -0.735135788931495 0.242888756475928 no 2557 0.231128400023447 849 1103068
SGTC_2002 4023503 131 µM -0.735681373618999 0.242728303991583 no 2558 0.230962313876525 865 4736863 YCR052W RSC6
SGTC_1888 azatryptophan 97.5 µM -0.736621435557467 0.242451973274536 no 2559 0.230676297871818 840 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1943 st076331 65.2 µM -0.736623616548807 0.242451332371473 no 2560 0.230675634530352 849 24208415
SGTC_1940 st075990 51.1 µM -0.736628695059385 0.242449840011019 no 2561 0.230674089921906 868 1084979
SGTC_911 3456-4043 236 µM -0.736747707463397 0.242414868700632 no 2562 0.230637894435119 840 914281
SGTC_1509 1326-1131 80 µM -0.737254754654229 0.242265905576925 no 2563 0.230483720697567 816 768313
SGTC_1382 3002-2117 298 µM -0.737819529198912 0.242100041415564 no 2564 0.23031206210824 878 1497314
SGTC_807 1315-0151 48 µM -0.73822158269618 0.241982003038383 no 2565 0.2301899048214 866 4011080
SGTC_3188 9110789 49.47 µM -0.738778761808239 0.24181847314669 no 2566 0.230020675121587 863 849217
SGTC_2687 chenodiol 100 µM -0.739617065708254 0.241572547257287 no 2567 0.229766191784787 821 5702181 A cholesterol synthesis inhibitor.
SGTC_2586 curcumin 80 µM -0.739665907219666 0.241558223237735 no 2568 0.22975136986284 865 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2705 st078069 42.8 µM -0.739671868509266 0.241556474969023 no 2569 0.229749560828357 845 1530061
SGTC_1715 st032160 10.2275 µM -0.741137915605929 0.241126735704562 no 2570 0.229304911150153 827 5289825
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.741834086089404 0.240922814369804 no 2571 0.229093932848834 846 2333 A French combination drug.
SGTC_734 2023-0417 80 µM -0.742673414624925 0.240677084144676 no 2572 0.228839714548419 861 3935732
SGTC_2716 st080858 38.6235 µM -0.744018235074742 0.240283645608882 no 2573 0.228432721659241 838 5296050
SGTC_670 4204-0025 119 µM -0.744560660773207 0.240125053642869 no 2574 0.228268678561425 840 719039
SGTC_1624 st003710 6.25 µM -0.745091381273803 0.239969939229821 no 2575 0.228108239517916 859 24207033
SGTC_203 k066-0004 30.888 µM -0.754711233944431 0.237167824857248 no 2576 0.22521113225578 864 6795412
SGTC_108 0509-0257 621.132 µM -0.755437984978314 0.23695686628739 no 2577 0.224993114482896 864 536624
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.755557406139894 0.236922211029318 no 2578 0.224957300818756 856 6710655
SGTC_1753 st043925 64 µM -0.756287375827739 0.236710439068995 no 2579 0.224738457696485 865 670181
SGTC_1498 4478-3555 97.6 µM -0.756547616026829 0.236634965806325 no 2580 0.224660467526048 847 3437919
SGTC_255 tunicamycin 200.472 nM -0.757814627546349 0.236267704110655 no 2581 0.224280982141044 852 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_279 1273-0055 2.93 µM -0.758160887607789 0.236167390240521 no 2582 0.224177336388445 879 2847562
SGTC_2583 asiatic acid 100 µM -0.758238892070083 0.236144795061028 no 2583 0.22415399112848 877 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3312 9133330 71.43 µM -0.758527919129213 0.236061084356632 no 2584 0.2240675028337 875 17617324
SGTC_718 1130-0073 349 µM -0.758947733121557 0.235939523051207 no 2585 0.223941911700363 866 6740020
SGTC_2621 lithochol-11-enic acid 100 µM -0.759009681075201 0.23592158832836 no 2586 0.223923382799852 867 6708711
SGTC_2479 5617353 43.85 µM -0.759107350168179 0.2358933134063 no 2587 0.223894171321847 864 2731746
SGTC_988 1497-1057 103 µM -0.760901013799764 0.235374385207047 no 2588 0.223358096491295 858 3533044
SGTC_3158 9100007 49.47 µM -0.761603723705971 0.23517125479489 no 2589 0.223148275859983 867 19297233
SGTC_512 prima-1 270 µM -0.761632626105739 0.235162902131316 no 2590 0.223139648358281 853 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_842 0271-0008 11.1 µM -0.762738698830625 0.234843375223722 no 2591 0.222809623200192 837 1221709
SGTC_562 3772-2733 112 µM -0.763152699893991 0.234723838615619 no 2592 0.222686166938616 843 2876874 YIL048W NEO1
SGTC_3225 9130819 49.47 µM -0.765409784840721 0.234072731145181 no 2593 0.222013784097114 867 4547121
SGTC_1615 st002656 86.5 µM -0.76564802736251 0.234004063084937 no 2594 0.22194287963501 852 1584458
SGTC_1571 st070080 73.4 µM -0.767105552984494 0.233584207080325 no 2595 0.221509380311588 857 4315245
SGTC_1698 5-fluorocytosine 1.055 µM -0.767110619004585 0.233582748487361 no 2596 0.221507874413319 852 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3314 9135860 59.4275 µM -0.768325608142967 0.233233078438103 no 2597 0.221146882229468 850 25252478
SGTC_1684 st024538 14.6195 µM -0.770770592915685 0.232530300907971 no 2598 0.220421460341774 857 6732859
SGTC_3335 9143315 29.6265 µM -0.77154387922942 0.232308275640391 no 2599 0.220192312111422 839 4899691
SGTC_1578 josamycin 24.2 µM -0.772138761347973 0.232137553921856 no 2600 0.220016123475724 856 5282165 A P450 substrate.
SGTC_661 1304-0007 33.6 µM -0.773075436923709 0.231868884507593 no 2601 0.219738868500126 857 3117130
SGTC_2671 danthron 100 µM -0.773928053584206 0.231624476610808 no 2602 0.219486669357328 865 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2928 9011484 9.79 µM -0.776480183932878 0.230893751299704 no 2603 0.218732758325706 853 2994751
SGTC_1044 1222-0021 1.78 µM -0.776499035845452 0.230888358418439 no 2604 0.21872719493489 845 4306703
SGTC_3270 9137563 49.47 µM -0.777044570242061 0.230732330333392 no 2605 0.218566237475391 836 17015724
SGTC_257 daunorubicin 18.5 µM -0.780623858721739 0.229710081636586 no 2606 0.217511877502646 847 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_570 0987-0065 62.6 µM -0.781412705020689 0.229485127871736 no 2607 0.217279900515047 837 3104428
SGTC_934 2950-0684 338 µM -0.781609524612158 0.229429020460591 no 2608 0.217222043819619 866 1121253
SGTC_2676 harmalol 100 µM -0.783416149445462 0.228914364782267 no 2609 0.216691387863406 849 5459187 A monoamine oxidase inhibitor
SGTC_1014 4130-3005 69.3 µM -0.7848705725917 0.228500512444379 no 2610 0.216264728621862 879 743608
SGTC_3029 9088683 49.47 µM -0.785271027412378 0.228386637903358 no 2611 0.216147339489174 845 25236615
SGTC_2309 7664088 163.95 µM -0.786723704751318 0.227973817968746 no 2612 0.215721812201444 868 704922
SGTC_2421 5690543 90.72 µM -0.791836644215428 0.226524173101009 no 2613 0.214227966301234 863 3397993
SGTC_2588 indole-3-carbinol 100 µM -0.792265237961044 0.226402893030919 no 2614 0.214103018181672 868 3712 Induces cell cycle arrest.
SGTC_2312 7706453 155.7 µM -0.793058331870809 0.226178566326742 no 2615 0.213871919054032 872 976098
SGTC_455 paf C-16 10 µM -0.793193039762727 0.226140476665832 no 2616 0.213832681042445 863 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3205 9113483 49.47 µM -0.794729922623912 0.22570616826012 no 2617 0.213385311244256 878 17018033
SGTC_2891 9063876 19.48 µM -0.797775661471898 0.224846867309644 no 2618 0.212500343794282 853 6472478
SGTC_675 1309-0189 238 µM -0.798359164646668 0.224682454246569 no 2619 0.212331046627116 857 4246530
SGTC_775 4577-0580 57.3 µM -0.799153331369633 0.224458792338114 no 2620 0.212100754388938 872 2006902
SGTC_2767 sibutramine 71.45 µM -0.800180902106393 0.224169584236635 no 2621 0.211802996563529 859 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.806339025667009 0.22244083110853 no 2622 0.210023697084418 865 15053
SGTC_3081 9117243 49.47 µM -0.806837356840282 0.222301269292725 no 2623 0.209880096737766 869 45595589
SGTC_105 0111-0055 734.78 µM -0.807571053145893 0.222095882450533 no 2624 0.209668778055801 878 5179370
SGTC_879 0831-1030 162 µM -0.814270852061275 0.220225395804881 no 2625 0.207744901973232 882 1549252
SGTC_738 1315-0003 72.4 µM -0.818313622607336 0.219101096810903 no 2626 0.206589064730488 886 6251474
SGTC_2829 7992743 58.44 µM -0.820413401689534 0.218518450598131 no 2627 0.205990239047058 886 16462845
SGTC_1398 3558-0053 112 µM -0.820556568182193 0.218478757308058 no 2628 0.205949447621616 855 4532369
SGTC_1147 3809-1045 12.3 µM -0.820772709439349 0.218418839437679 no 2629 0.205887873085908 860 325925
SGTC_1838 st055369 84.5 µM -0.82136074377044 0.21825587466996 no 2630 0.205720408565606 860 676036
SGTC_746 1095-0025 46.6 µM -0.821564877840967 0.21819931840395 no 2631 0.205662292747817 876 6749286
SGTC_1060 3448-7350 82 µM -0.823031882641488 0.21779312660225 no 2632 0.205244931488871 888 570178
SGTC_1673 st016611 27.3 µM -0.824792100001589 0.21730632473118 no 2633 0.20474481626427 896 5226799
SGTC_2620 irigenin 100 µM -0.826163492216319 0.216927491371433 no 2634 0.204355677358604 877 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3288 9119690 36.221 µM -0.826597889152443 0.216807573228174 no 2635 0.204232507094792 902 17595618 YKL019W RAM2
SGTC_1996 st072960 66.8 µM -0.827349406911991 0.216600202327439 no 2636 0.204019523830093 865 1719405
SGTC_3197 9113331 49.47 µM -0.827454514113769 0.216571208601843 no 2637 0.203989746562702 872 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2382 9035899 200 µM -0.82774560522667 0.216490923104984 no 2638 0.203907292868182 883 6462679
SGTC_2158 5657123 3.6195 µM -0.828377526898938 0.216316692819195 no 2639 0.203728364788942 906 2858827
SGTC_19 0279-0214 38.434 µM -0.828471567052572 0.216290771478224 no 2640 0.203701745403961 884 3566274 YBR002C RER2
SGTC_1338 1486-1223 76 µM -0.828551347670333 0.216268782062804 no 2641 0.203679164006661 886 3444526
SGTC_33 0986-0033 35.816 µM -0.829567689536699 0.215988767618145 no 2642 0.203391625535267 834 2848082
SGTC_2075 5212009 200 µM -0.830247171690819 0.215801679296341 no 2643 0.203199524922596 871 780898
SGTC_3353 9151644 39.2805 µM -0.830842636338842 0.215637801568489 no 2644 0.20303126649361 884 4909158
SGTC_1431 4049-0260 9.09 µM -0.834062799244503 0.214752832161781 no 2645 0.202122798370765 884 3854841
SGTC_2115 tiliquinol 12.7705 µM -0.83472924154566 0.21456994353193 no 2646 0.201935086784791 879 71208 A bioactive hydroxyquinoline.
SGTC_1988 st071872 53.4 µM -0.835343488773048 0.214401458759136 no 2647 0.201762169026815 872 16414116
SGTC_2395 5646831 180.19 µM -0.835692177912261 0.21430584941151 no 2648 0.20166404843538 891 6808628
SGTC_2708 st078559 56 µM -0.836298800791265 0.214139574646221 no 2649 0.201493413815534 855 17250902
SGTC_1140 3229-1848 2.98 µM -0.836385620647112 0.214115783547058 no 2650 0.201468999670728 883 2849525
SGTC_1462 k081-0014 26.5 µM -0.837062603977393 0.213930323708648 no 2651 0.201278689638535 835 3270634
SGTC_2015 5119600 184 µM -0.839618551927173 0.213230964434134 no 2652 0.20056114699818 885 2828786
SGTC_916 4466-0038 42 nM -0.839622763661131 0.213229813119554 no 2653 0.200559965888419 895 5722064 YGL116W CDC20
SGTC_2167 5876490 200 µM -0.840640214490907 0.212951790203977 no 2654 0.200274761354358 876 686534
SGTC_2998 9066762 71.4286 µM -0.842640678943832 0.212405771740631 no 2655 0.199714716567852 873 4945196
SGTC_2477 5967686 25.23 µM -0.842879446119371 0.212340655920737 no 2656 0.199647934932638 895 776118
SGTC_2435 5706476 10.6 µM -0.84492129645562 0.211784285646569 no 2657 0.199077391554462 856 5725375
SGTC_3116 9124943 49.47 µM -0.845370155037248 0.211662093614423 no 2658 0.198952101223642 862 41905195 YPL160W CDC60
SGTC_2909 7941780 10.49 µM -0.845754051480783 0.211557618864663 no 2659 0.198844981548606 868 1243215
SGTC_2935 9038016 29.96 µM -0.848575588699072 0.210790684006651 no 2660 0.198058747605856 888 6463195
SGTC_784 4579-0127 173 µM -0.849377324442177 0.210573058442304 no 2661 0.197835683320823 912 1948547
SGTC_2292 7671323 168.05 µM -0.849523198393368 0.210533476159547 no 2662 0.197795113620358 903 937504
SGTC_1701 st028638 40.4 µM -0.85104961802023 0.210119550591869 no 2663 0.197370895350238 892 3490878
SGTC_3216 9129716 49.47 µM -0.852542290501936 0.209715239079409 no 2664 0.196956588587727 873 8056934
SGTC_1713 st033146 12.748 µM -0.852675516349979 0.20967917521879 no 2665 0.196919635977422 890 674619
SGTC_104 0074-0074 590.992 µM -0.854369430833766 0.209220955410647 no 2666 0.196450164042666 881 3943124
SGTC_415 dibenzyl ketone 100 µM -0.854714331114374 0.20912772892252 no 2667 0.196354657391973 885 7593
SGTC_347 4534-1311 26.2 µM -0.857186043492067 0.208460341547638 no 2668 0.195671037194255 897 2862016
SGTC_1245 0418-0076 17.2 µM -0.85791891134299 0.208262701479474 no 2669 0.195468620435227 901 6790114
SGTC_2696 st077691 74.316 µM -0.860615293297589 0.207536492462685 no 2670 0.194724980062846 901 757133
SGTC_992 3909-8734 162 µM -0.862281994718786 0.207088353817289 no 2671 0.194266179180203 894 4288319
SGTC_910 3454-3003 490 µM -0.862880744078489 0.206927503411347 no 2672 0.194101519428672 915 820824
SGTC_1116 jasmonic acid 1.58368 µM -0.864297323044116 0.206547242539302 no 2673 0.193712290178997 884 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2028 5153890 36.43 µM -0.864454032136827 0.206505201610929 no 2674 0.193669260934701 904 2830968 YPR165W RHO1
SGTC_2131 toluylene red 5.2905 µM -0.864555388960322 0.206478012940528 no 2675 0.193641433442334 866 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1833 st055984 71 µM -0.865081793704935 0.206336840524963 no 2676 0.193496948360948 883 676288
SGTC_1348 1493-0373 93.8 µM -0.865455027897681 0.206236780400149 no 2677 0.19339454466152 901 3010129
SGTC_1467 k284-1082 293 µM -0.866128099336963 0.206056409812647 no 2678 0.19320995867237 893 3334705
SGTC_1644 st010134 20.9 µM -0.866669339480258 0.205911435432591 no 2679 0.193061604694361 889 3818134
SGTC_1950 st077106 7.18 µM -0.866879853629623 0.205855064317711 no 2680 0.193003921536785 876 13831864
SGTC_505 gw-5074 63.9 µM -0.87014420299586 0.204982114816478 no 2681 0.192110801909858 903 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2532 xanthone 78.9 µM -0.871667043171074 0.20457563211074 no 2682 0.191695022211838 888 7020 An insecticide.
SGTC_1472 k841-0093 193 µM -0.871794593008128 0.204541607770966 no 2683 0.191660222422818 903 X1472
SGTC_1853 st056710 91.2 µM -0.872133270096343 0.20445128088345 no 2684 0.191567838956381 901 269167
SGTC_2788 5282734 71.43 µM -0.873495708954953 0.204088151503489 no 2685 0.191196472052586 899 743706
SGTC_886 0866-0150 153 µM -0.873587884293467 0.204063597992043 no 2686 0.191171363301151 906 271463
SGTC_515 4092-1064 102 µM -0.874108095391968 0.203925058030384 no 2687 0.191029694634555 928 717353
SGTC_632 0781-2353 4.65 µM -0.874730284729931 0.203759433373214 no 2688 0.190860338898226 915 6811515 YHR007C ERG11
SGTC_3180 9109287 49.47 µM -0.879073538320289 0.202605509652518 no 2689 0.189680702154927 878 18891271
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.879288804699629 0.202548419055864 no 2690 0.189622352237996 899 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_679 0422-0091 41.4 µM -0.879547841863324 0.20247973280013 no 2691 0.189552152490572 907 627384 YHR062C RPP1
SGTC_3287 9117173 37.0625 µM -0.880350520693126 0.202266983052904 no 2692 0.189334725993053 865 2789709
SGTC_2789 5281112 71.43 µM -0.880852439648321 0.202134017581033 no 2693 0.1891988461968 892 765948
SGTC_1090 efavirenz 20.7 µM -0.881371748811537 0.201996500260396 no 2694 0.189058321732184 884 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1302 1159-0335 255 µM -0.881788306395899 0.201886232883758 no 2695 0.188945648204398 897 649284
SGTC_3282 9108498 15.4605 µM -0.882580639938128 0.201676592965205 no 2696 0.188731446271669 922 16459645
SGTC_808 0711-0032 135 µM -0.882654970915032 0.201656932763158 no 2697 0.188711359084591 874 4252555
SGTC_1751 st044839 27.194 µM -0.884276362546922 0.201228367821904 no 2698 0.1882735225018 875 5291326
SGTC_1323 1348-1351 11.2 µM -0.884412785823941 0.201192333454289 no 2699 0.188236711705232 873 6989654
SGTC_2551 apiole 73.87 µM -0.884916948894815 0.201059199157651 no 2700 0.188100713012995 877 10659 A possible DNA adduct former.
SGTC_1967 st070177 51.4 µM -0.885019797163778 0.201032046515317 no 2701 0.188072976998213 910 5729214
SGTC_3238 9133470 49.47 µM -0.887748182217781 0.200312537732897 no 2702 0.187338110924805 879 3534688
SGTC_3226 9131256 49.47 µM -0.889082776594411 0.199961152969523 no 2703 0.186979297298799 865 17178073
SGTC_2918 7977171 22.06 µM -0.889502280711417 0.199850778522567 no 2704 0.186866599013698 880 2236483
SGTC_2393 9031399 185.94 µM -0.889860230673004 0.199756628379697 no 2705 0.18677047027686 919 1526623 YDL150W RPC53
SGTC_2529 gangaleoidin 93.61 µM -0.892039953517149 0.199183880791355 no 2706 0.186185758869557 900 4565183
SGTC_1463 k081-0032 34.1 µM -0.893188556847272 0.198882470240751 no 2707 0.185878102542401 860 977755
SGTC_1146 3579-1023 7 µM -0.897212191952269 0.197828779006517 no 2708 0.184802850355358 924 X1146
SGTC_1247 0448-0043 5.84 µM -0.897832746958186 0.197666571616793 no 2709 0.184637361737111 926 3089013 YGL099W LSG1
SGTC_552 k242-0005 476 µM -0.898916018222515 0.197383607148616 no 2710 0.184348697592696 919 4088318
SGTC_2828 7998861 71.43 µM -0.900560570771706 0.196954497294467 no 2711 0.1839110033609 852 2988188
SGTC_1158 4092-0494 91.8 µM -0.900920908274754 0.196860550618974 no 2712 0.183815186791661 902 1148199
SGTC_2760 etidronate 98.04 µM -0.902278862508374 0.196506750611417 no 2713 0.183454375572844 898 3305 A chelator and antioxidant.
SGTC_2262 9014885 67.46 µM -0.904112795612223 0.19602955156127 no 2714 0.182967797063342 906 6457424
SGTC_3277 9138724 49.47 µM -0.90428209816412 0.195985533616043 no 2715 0.182922918407203 879 15943418
SGTC_1102 cgs 12066b 26.1 µM -0.904374325580197 0.195961557402266 no 2716 0.182898473689441 882 6438352 A 5-HT1B full agonist.
SGTC_4 0960-0234 25.671 µM -0.905863061093678 0.195574779460226 no 2717 0.182504169007232 875 6821112
SGTC_2817 7995342 71.43 µM -0.906569817110907 0.195391324510658 no 2718 0.182317164474399 925 18879975
SGTC_2580 diallyl disulphide 81.36 µM -0.907011859614818 0.19527663526088 no 2719 0.182200262858275 897 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_940 3232-1287 54.8 µM -0.907236466001473 0.195218376137368 no 2720 0.182140881887327 897 1585493 YIL048W NEO1
SGTC_2048 5246248 200 µM -0.908164158030135 0.19497786033568 no 2721 0.181895748783412 880 677046
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.908350017136313 0.19492969570239 no 2722 0.181846662242029 905 6728940
SGTC_1399 3562-5772 25 µM -0.908426436378698 0.194909894064875 no 2723 0.18182648185064 899 23847490
SGTC_1948 st076329 66.6 µM -0.910616647879534 0.194342889839736 no 2724 0.181248697843747 890 24208413
SGTC_1672 st016598 6.51 µM -0.910750612732095 0.194308241502932 no 2725 0.181213394891248 913 4665860 YNL267W PIK1
SGTC_2469 5655019 90.81 µM -0.911807912226119 0.194034916198234 no 2726 0.180934922254868 904 2788239
SGTC_1875 nocodazole 6 µM -0.912059715177513 0.193969856501305 no 2727 0.180868641693061 893 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1420 4'-methoxyflavone 42 µM -0.91216915632651 0.193941583741671 no 2728 0.18083983890911 883 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1756 st041558 35.5 µM -0.913784400036039 0.193524597729133 no 2729 0.180415072548528 942 3955792
SGTC_189 3970-0742 2.116 µM -0.913949892613847 0.193481905615256 no 2730 0.18037158775805 888 2891807
SGTC_253 dyclonine 31.25 µM -0.916733170165603 0.192764764708568 no 2731 0.179641239970052 894 3180 An oral anasthetic.
SGTC_1106 tegaserod maleate 11.7 µM -0.917576194159943 0.192547871510591 no 2732 0.179420392887643 908 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_643 k048-0106 28.4 µM -0.91866218443718 0.192268687912917 no 2733 0.1791361475916 904 6763920
SGTC_2342 7990637 118.86 µM -0.91950089819821 0.192053243066929 no 2734 0.178916818017341 934 2033102 YER133W GLC7
SGTC_2879 9041815 71.43 µM -0.919978431732458 0.191930642526063 no 2735 0.178792015163134 888 4942971
SGTC_1354 1498-1681 81 µM -0.923496195699126 0.191028979254553 no 2736 0.177874341003664 921 5754243
SGTC_1388 3346-4487 254 µM -0.924061537282392 0.190884315186058 no 2737 0.177727138695244 937 3345614
SGTC_1979 st071809 45.3 µM -0.926245017604609 0.190326220335017 no 2738 0.177159331165259 932 4976333
SGTC_2263 7948595 193.29 µM -0.926642156084214 0.190224820065364 no 2739 0.177056179782881 893 2971371
SGTC_3142 9086498 49.47 µM -0.927751536002443 0.189941741058944 no 2740 0.176768234356649 878 25236367
SGTC_1022 4477-0945 21.3 µM -0.92858980007753 0.189728014187623 no 2741 0.176550854950021 886 4648966
SGTC_2749 bexarotene 57.39 µM -0.928708019856693 0.189697884345958 no 2742 0.176520211697405 920 82146 An retinoic acid receptor inhibitor.
SGTC_539 4859-0462 2.54 µM -0.929623352832799 0.18946469950316 no 2743 0.176283065946917 896 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.930143733312581 0.189332209116512 no 2744 0.176148334973682 898 5024745
SGTC_173 1273-0061 2.693 µM -0.93158091113493 0.188966595810374 no 2745 0.175776575991176 890 2847414 YPL266W DIM1
SGTC_857 0438-0306 1.35 µM -0.932509130716377 0.188730691140618 no 2746 0.175536735082194 889 4686136
SGTC_1272 0839-0021 27 µM -0.933112282992502 0.188577498849411 no 2747 0.175380998928457 930 5027250
SGTC_1650 st011916 45.8 µM -0.933310332327214 0.188527213797201 no 2748 0.175329880965599 932 242528
SGTC_3034 9090421 49.47 µM -0.936799547962791 0.187642652717733 no 2749 0.174430838943817 888 17173761
SGTC_83 0170-0301 39.027 µM -0.937650118270506 0.187427411529591 no 2750 0.1742121231058 906 3089716
SGTC_1741 st038134 10.228 µM -0.939326190310742 0.187003719751697 no 2751 0.173781647908494 933 1272587
SGTC_3129 9127257 49.47 µM -0.939572209054525 0.186941578944836 no 2752 0.173718518495474 920 837894
SGTC_2713 st079149 53.4 µM -0.939671350866406 0.186916540757033 no 2753 0.173693082426871 893 3103253
SGTC_50 0929-0078 56.389 µM -0.940096356743042 0.186809229368393 no 2754 0.173584068719197 881 1377751
SGTC_2605 digitonin 300 nM -0.94068438334415 0.186660819131572 no 2755 0.173433312117357 901 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2693 st077581 40.7 µM -0.940808872425131 0.186629409078093 no 2756 0.173401406650597 885 25238761
SGTC_3218 9131285 49.47 µM -0.941462564676676 0.186464528579557 no 2757 0.173233932348075 925 17156417
SGTC_3133 9127736 49.47 µM -0.942077692409287 0.186309457614424 no 2758 0.173076432275502 899 27243420
SGTC_1849 st056239 19.2 µM -0.942429097643627 0.186220905789996 no 2759 0.172986497849274 885 5393181
SGTC_772 k072-0172 35.3 µM -0.94518530199881 0.1855272651563 no 2760 0.172282140943878 881 5861980
SGTC_2569 tetrandrine 100 µM -0.94677336011305 0.185128335319887 no 2761 0.171877139656682 913 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2792 7535235 81.82 µM -0.947803046606196 0.184869956784804 no 2762 0.171614864635743 914 1281891
SGTC_685 1278-0033 54.9 µM -0.948086963545349 0.184798753135625 no 2763 0.171542592162444 920 3590572
SGTC_967 1306-0166 352 µM -0.948758999231798 0.184630280962123 no 2764 0.171371599638993 912 4437607
SGTC_2320 7373003 200 µM -0.949229012214343 0.184512510496357 no 2765 0.171252074469664 907 5415828
SGTC_789 1309-1135 70.6 µM -0.950030792810328 0.184311717367276 no 2766 0.17104830323057 895 3092424
SGTC_1855 st056195 39.6 µM -0.951429380187936 0.183961789105437 no 2767 0.170693225899241 879 4028379
SGTC_1334 1486-0610 236 µM -0.952503560392577 0.183693308992958 no 2768 0.170420830568945 889 3742339
SGTC_2216 7189485 200 µM -0.953514723562586 0.183440802516113 no 2769 0.170164669902427 900 731273
SGTC_366 0181-0206 4.31 µM -0.954266124474665 0.183253303770408 no 2770 0.169974475381815 936 274874
SGTC_1452 4194-0072 190 µM -0.95506829732666 0.183053267742738 no 2771 0.169771579929437 928 1343545
SGTC_3055 9094636 49.47 µM -0.960697652540243 0.181653323399505 no 2772 0.168352105944592 925 25236176
SGTC_2777 climbazole 1.536 µM -0.961495368511374 0.18145548559034 no 2773 0.168151576554162 918 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_358 0075-0058 9.45 µM -0.961789146046681 0.181382661192984 no 2774 0.168077765659171 959 1069125
SGTC_2742 clothiapine 36.27 µM -0.962761860519808 0.181141666011487 no 2775 0.167833522329561 903 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3261 9137475 49.47 µM -0.964435466966217 0.180727490807542 no 2776 0.16741382391543 863 17027690
SGTC_110 0850-0284 111.64 µM -0.966900844982086 0.180118454677205 no 2777 0.166796802097875 862 3906265
SGTC_1854 st056233 32.9 µM -0.967049035918411 0.180081887337253 no 2778 0.166759760455417 945 5393174
SGTC_1200 1643-0193 18.4 µM -0.968014983728697 0.179843645937558 no 2779 0.16651844327357 921 5403974
SGTC_473 2-arachidonoylglycerol 10 µM -0.970846268877307 0.179146478926626 no 2780 0.165812419026812 895 5282280 An endocannabinoid.
SGTC_208 k072-0098 12.366 µM -0.972972904819609 0.178623942182767 no 2781 0.165283384353763 937 5948901
SGTC_2814 7977482 42.97 µM -0.976082442288508 0.177861625900003 no 2782 0.164511805693975 913 6456762
SGTC_674 0498-0004 451 µM -0.978615636060063 0.177242121803017 no 2783 0.163884965252749 904 4231473
SGTC_756 0508-1999 28.3 µM -0.978991337665571 0.177150358439302 no 2784 0.163792129803826 927 6753853
SGTC_1619 st003326 88.7 µM -0.979003477124136 0.177147393933778 no 2785 0.163789130726479 861 2849032
SGTC_1872 amphotericin b 148 nM -0.97986148552973 0.176937944148192 no 2786 0.163577248333853 911 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3104 9120930 49.47 µM -0.979875739331942 0.176934465952065 no 2787 0.163573729907218 921 17014836
SGTC_792 4534-1957 155 µM -0.98129941092935 0.176587280973369 no 2788 0.163222556579454 921 1717904
SGTC_3235 9132602 49.47 µM -0.983288628510802 0.176102900678588 no 2789 0.162732702595055 925 4912240
SGTC_591 4299-0174 154 µM -0.984417265214513 0.17582844869251 no 2790 0.162455196226956 959 5509088
SGTC_567 1080-0542 68.4 µM -0.987000276413659 0.175201354825996 no 2791 0.161821251545583 888 5950415
SGTC_2017 5132927 60.65 µM -0.988663373019776 0.174798346012296 no 2792 0.161413934372895 932 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1936 st074407 74.3 µM -0.988849270550918 0.174753335103646 no 2793 0.161368446873534 940 809813
SGTC_1262 0737-0114 49.6 µM -0.990772811090371 0.174288025014302 no 2794 0.16089826418732 940 765919
SGTC_2372 9071633 200 µM -0.991161447886695 0.174194108319624 no 2795 0.160803376043658 940 21321366
SGTC_2876 9059903 25.97 µM -0.991204434481556 0.174183722295831 no 2796 0.160792882837922 891 6916095
SGTC_3237 9133362 49.47 µM -0.992000031702379 0.173991568500241 no 2797 0.160598754975656 939 43845137
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.992565104697317 0.173855173138457 no 2798 0.160460968661573 936 390807
SGTC_550 4123-0385 25.7 µM -0.99427769521313 0.173442209462097 no 2799 0.160043845783122 940 5731123
SGTC_332 4112-0506 40.9 µM -0.996190436478005 0.172981721388236 no 2800 0.159578812605973 923 2790355
SGTC_3127 9126946 49.47 µM -0.996843674468659 0.172824634439944 no 2801 0.159420197608559 913 27243249
SGTC_1349 flufenamic acid 69 µM -0.997089954242578 0.172765434090824 no 2802 0.159360424358683 928 3371 A non-steroidal anti-inflammatory.
SGTC_2859 9028643 45.46 µM -0.998878385337693 0.172335921616121 no 2803 0.158926804045834 882 17151580
SGTC_2959 9079155 11 µM -1.00082052256866 0.171870267087209 no 2804 0.158456792945302 921 16189457
SGTC_2490 carminic acid 95.39 µM -1.0012226105441 0.171773961361267 no 2805 0.158359598818333 915 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2238 6671620 73.2395 µM -1.00140040103667 0.17173138902888 no 2806 0.158316635145102 912 729941
SGTC_3352 9151559 45.5865 µM -1.00208443918174 0.171567657413396 no 2807 0.158151406339745 914 17159339
SGTC_1755 st041960 45.185 µM -1.00218086348558 0.171544585281262 no 2808 0.158128124239728 934 2257073
SGTC_2407 paclitaxel 400 µM -1.00373373532732 0.171173291632129 no 2809 0.157753485915483 968 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2161 5662504 8.5105 µM -1.00511468410473 0.170843537052743 no 2810 0.157420815075452 895 2859334
SGTC_2125 5246583 200 µM -1.00554691581437 0.17074040870868 no 2811 0.157316785184843 925 835267
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.00575556396496 0.17069064055597 no 2812 0.157266583750342 930 6857784
SGTC_128 0906-2981 13.371 µM -1.0078204222884 0.170198617478372 no 2813 0.15677033995333 921 6740226
SGTC_2871 9038510 12.99 µM -1.0086559857224 0.169999774458281 no 2814 0.156569823641776 920 4945164
SGTC_3001 9076041 71.4286 µM -1.01062450318145 0.169531905887513 no 2815 0.156098091778504 929 16004211
SGTC_34 0469-0683 81.75 µM -1.01102527491828 0.169436753542302 no 2816 0.156002166453985 935 3690923
SGTC_1893 st059353 36.1 µM -1.01260617754615 0.1690617455416 no 2817 0.155624153984284 976 3112488
SGTC_357 1325-0123 420 µM -1.01338500420601 0.168877195176639 no 2818 0.155438149656932 958 1098503
SGTC_3064 1327-0027 10 µM -1.01518707512891 0.168450673792107 no 2819 0.155008330230985 897 16000455 YPR107C YTH1
SGTC_976 1348-1067 47.6 µM -1.01864189772006 0.167634911264243 no 2820 0.154186502883155 929 5310671 YGL099W LSG1
SGTC_2151 5563267 85.4165 µM -1.01891728330334 0.16756999611144 no 2821 0.154121118870318 961 5310824
SGTC_1581 himbacine 57.9 µM -1.02270795894552 0.16667808652775 no 2822 0.153222973587452 964 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_943 3253-1379 105 µM -1.02360141157654 0.166468312643839 no 2823 0.153011789114381 928 668464
SGTC_1430 4049-0248 69.1 µM -1.02453623270453 0.166249008389756 no 2824 0.152791033075269 941 22774488
SGTC_537 1334-0398 209 µM -1.02521157456925 0.16609069279281 no 2825 0.152631684000036 925 5846986
SGTC_365 0121-0052 13.6 µM -1.02603849476802 0.165896976458265 no 2826 0.152436719730634 908 3101739
SGTC_112 phenothiazine 287.218 µM -1.02636163391505 0.165821316794761 no 2827 0.152360577640085 931 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_181 1447-1644 8.07 µM -1.02736706621486 0.165586047997367 no 2828 0.152123826594269 970 534600
SGTC_860 0443-0016 25.1 µM -1.02832567187077 0.16536193765838 no 2829 0.151898329521753 927 5337942
SGTC_2524 avocatin b 10.57 µM -1.03096115273537 0.164746806292638 no 2830 0.151279518678493 923 6710748
SGTC_2081 5214970 32.255 µM -1.03148150260197 0.164625530089488 no 2831 0.151157539036742 941 2063512
SGTC_2139 5578692 56.4705 µM -1.03160833991704 0.164595977311864 no 2832 0.151127815943731 910 650991 YMR113W FOL3
SGTC_272 doxorubicin 8.13 µM -1.03218584319988 0.164461463953127 no 2833 0.150992532820584 947 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2235 salicylic acid 500 µM -1.0350631760349 0.163792331402153 no 2834 0.150319704149699 942 338 A COX inhibitor and kinase inhibitor.
SGTC_1189 1431-2119 7.28 µM -1.03963656696892 0.162732416998276 no 2835 0.149254390690637 933 3107275
SGTC_1810 st050138 53 µM -1.04015778735002 0.162611904451017 no 2836 0.149133299809575 953 3444541
SGTC_701 4424-0219 185 µM -1.04092410097096 0.162434828801659 no 2837 0.148955387594777 956 2911779
SGTC_10 0279-0212 42.575 µM -1.04284374388977 0.161991799135233 no 2838 0.148510333919293 950 39851 YBR002C RER2
SGTC_958 1222-0007 33 µM -1.04496517778109 0.161503115038005 no 2839 0.148019531950211 934 7312461
SGTC_1230 0170-0365 3.77 µM -1.04572282329581 0.161328820364308 no 2840 0.147844511111208 905 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2418 pentamidine 31.67 µM -1.0465901822626 0.161129437030552 no 2841 0.147644315953383 895 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1184 1269-1718 139 µM -1.04716771804775 0.160996765740602 no 2842 0.147511115640629 921 5403821
SGTC_585 0kpi-0023 191 µM -1.04771155169467 0.160871901688163 no 2843 0.147385761860891 897 64601
SGTC_1466 k213-0079 57.5 µM -1.04961988162076 0.160434249955835 no 2844 0.146946456241069 964 3657981
SGTC_1299 1079-1439 3.74 µM -1.05297226501723 0.159667308003835 no 2845 0.146176851828699 950 323161
SGTC_1634 st006576 41 µM -1.05352947280335 0.159540065626227 no 2846 0.146049196870223 934 3915356
SGTC_628 1636-0253 16 µM -1.05462695791645 0.159289641220545 no 2847 0.145797984768069 935 4456143
SGTC_823 0417-1665 178 µM -1.05674361595749 0.158807389077012 no 2848 0.145314306715981 965 3429856
SGTC_185 k048-0037 25.491 µM -1.05686258339056 0.158780312379314 no 2849 0.145287153517284 935 6827589
SGTC_2847 9005661 71.43 µM -1.05860271854948 0.158384607744771 no 2850 0.144890374153269 921 2991449
SGTC_3067 9117431 49.47 µM -1.05877130441012 0.158346305927536 no 2851 0.144851972613708 984 17150885
SGTC_3075 9116269 49.47 µM -1.06477614507638 0.156986001240243 no 2852 0.143488621315408 937 17015205 YNL244C SUI1
SGTC_592 k241-0073 46.5 µM -1.0656573165117 0.156787034071291 no 2853 0.143289289604077 949 4230158
SGTC_1555 citronellol 128 µM -1.06746936631468 0.156378397729791 no 2854 0.142879969796422 949 8842 A terpine precursor.
SGTC_1861 st057647 17.4 µM -1.06928302421699 0.155970101743457 no 2855 0.142471078777029 943 688668
SGTC_1812 st052057 4.327 µM -1.06935835160117 0.155953159033501 no 2856 0.142454113277602 955 3645418
SGTC_2692 st077426 47.7 µM -1.07090934723542 0.155604577209045 no 2857 0.142105096287979 964 25238571
SGTC_2834 9001755 58.44 µM -1.07179463704609 0.155405841424792 no 2858 0.141906141224576 948 2989575
SGTC_478 N-arachidonylglycine 10 µM -1.07846851401535 0.153913037392381 no 2859 0.140412362823769 942 5283389
SGTC_3020 9089140 49.47 µM -1.07883878665716 0.153830494071541 no 2860 0.140329800435987 965 17217859
SGTC_2598 perillyl alcohol 100 µM -1.08210743791284 0.153103098557009 no 2861 0.139602395595591 957 10819 An apoptosis inducer.
SGTC_813 k007-0158 173 µM -1.08605955304281 0.152226656555277 no 2862 0.138726322737534 950 6523916
SGTC_1851 st056236 18.9 µM -1.08646989235455 0.152135848797601 no 2863 0.138635577104494 908 5393171
SGTC_275 trichlorophene 5.69 µM -1.08884815983719 0.151610248656348 no 2864 0.138110424978451 917 62616
SGTC_2861 9024595 19.48 µM -1.09002603653587 0.151350383870361 no 2865 0.137850837546421 936 16482810
SGTC_2324 6149169 200 µM -1.09091988204564 0.15115338024302 no 2866 0.137654068873823 948 2888231
SGTC_2495 cafestol 54.53 µM -1.09741858026232 0.149726197446389 no 2867 0.13622922742563 950 16667697 An anti-infammatory.
SGTC_204 PMA1.184 62.41 µM -1.09775055294527 0.149653534875798 no 2868 0.136156714254757 957 2252213 YGL008C PMA1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.09953861225922 0.149262567058157 no 2869 0.135766600777757 938 17037758
SGTC_3093 9117344 49.47 µM -1.10018706419078 0.149120948574139 no 2870 0.135625312797944 931 24824913
SGTC_228 caffeine 993.056 µM -1.10237556405238 0.148643654465097 no 2871 0.135149215216506 949 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1101 ebselen 5.29 µM -1.10262840394423 0.148588578014111 no 2872 0.135094285054049 960 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_517 1365-0151 113 µM -1.10374441579054 0.1483456387018 no 2873 0.134852011346865 956 768657
SGTC_2360 9040895 200 µM -1.10404292984491 0.148280701659486 no 2874 0.134787257839805 959 4914414
SGTC_42 0133-0086 60.653 µM -1.10459402651752 0.148160869202274 no 2875 0.134667770304113 964 162923 Model of phenazepam hydroxylation.
SGTC_1519 esterone 74 µM -1.10489292893911 0.148095901888269 no 2876 0.134602993371438 955 698 A steroid.
SGTC_1811 st050069 61.5 µM -1.10539916771127 0.147985912905932 no 2877 0.134493332127356 933 3877702
SGTC_737 1950-0117 57.9 µM -1.11040782310581 0.146900644323736 no 2878 0.133411664313865 947 5393513
SGTC_2174 5790901 200 µM -1.11265608425889 0.146415234458967 no 2879 0.13292808165971 960 786020
SGTC_3030 9087619 49.47 µM -1.11614509009551 0.145664076575547 no 2880 0.132180017036295 936 25236973
SGTC_1597 7-benzyloxygramine 47.5 µM -1.11728476302109 0.145419275546445 no 2881 0.131936294127716 951 260807
SGTC_3224 9130643 49.47 µM -1.11841767013604 0.145176202224102 no 2882 0.131694325498819 970 17644395
SGTC_2627 acetyl isogambogic acid 100 µM -1.11846855855488 0.145165290170258 no 2883 0.131683463836869 974 6857789 A caspase activator and apoptosis inducer.
SGTC_1433 4060-0023 7.6 µM -1.12898213019879 0.142922687026816 no 2884 0.129452686040613 955 3840627
SGTC_2497 7-hydroxyflavone 100 µM -1.1292646654232 0.142862745511372 no 2885 0.129393100980408 954 5281894
SGTC_1221 2958-7315 257 µM -1.12975434487628 0.142758897373957 no 2886 0.12928987540892 967 4562705
SGTC_1231 0242-0792 125 µM -1.12979270989733 0.142750763317904 no 2887 0.129281790384692 964 3707635
SGTC_2266 7929956 200 µM -1.1301141621469 0.142682622124263 no 2888 0.129214061476508 963 2967153
SGTC_1920 st075728 45.7 µM -1.13053915829713 0.142592565539641 no 2889 0.129124553978351 935 3400306
SGTC_2143 5623677 140.463 µM -1.13268569088211 0.142138303189424 no 2890 0.128673134394119 917 5375313
SGTC_1919 st067113 52.3 µM -1.13365633104668 0.141933212311991 no 2891 0.128469367018989 970 1268243
SGTC_1860 st056228 74.6 µM -1.1366521068116 0.141301485487444 no 2892 0.127841874015362 981 688679
SGTC_2782 7736369 71.43 µM -1.13788135104001 0.141042823966056 no 2893 0.127585014708733 965 2950836 YOL077C BRX1
SGTC_1394 3474-0001 65.7 µM -1.13903937531635 0.140799442702946 no 2894 0.12734336574596 947 5017666 YIL048W NEO1
SGTC_154 3389-1638 511.116 µM -1.13968041982846 0.140664837366402 no 2895 0.127209733729041 988 5238686
SGTC_3007 9078383 71.4286 µM -1.14121867783842 0.14034219312456 no 2896 0.126889466799623 962 6496995
SGTC_1212 0520-0165 585 µM -1.14148246125525 0.140286915993741 no 2897 0.126834603244769 994 5403258
SGTC_2523 spermine 47.74 µM -1.14216638414596 0.140143665417095 no 2898 0.126692433014411 940 1103 A DNA binding polyamine.
SGTC_2770 toltrazuril 17.5 µM -1.14294036539479 0.139981671630699 no 2899 0.126531675836573 924 68591 Kills coccidiodes.
SGTC_1173 0443-0020 122 µM -1.14298207796201 0.139972944831816 no 2900 0.126523016104832 970 5331295
SGTC_2572 astragaloside iv 100 µM -1.14307180966098 0.139954173073762 no 2901 0.12650438876723 953 45006101 An anti-inflammatory agent.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.14443715083267 0.13966875648246 no 2902 0.126221194263413 916 279621
SGTC_1889 st059080 5.18 µM -1.1481498310612 0.138894644752354 no 2903 0.125453357938546 966 176925 Isolated from Daphnopsis sellowiana.
SGTC_339 3091-4833 71.4 µM -1.1494913234408 0.138615657002856 no 2904 0.125176721230866 959 3240077
SGTC_386 1509-0011 3.07 µM -1.14961084983804 0.138590817850152 no 2905 0.125152093702391 965 3107280
SGTC_3 0833-0587 95.581 µM -1.14994949925989 0.13852045852786 no 2906 0.125082335873129 964 5382644
SGTC_1141 3253-0389 52.6 µM -1.15348675834532 0.137786996560044 no 2907 0.124355324770357 973 5402031
SGTC_696 1560-0013 611 µM -1.15800381083531 0.136854230187575 no 2908 0.123431240631434 968 1650269
SGTC_389 tpck 16.7 µM -1.15892420630224 0.136664700094067 no 2909 0.123243540530313 975 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1685 st024049 53.0905 µM -1.16101751678058 0.136234308980414 no 2910 0.122817387979438 967 1941139
SGTC_1779 st039427 55 µM -1.16135567911474 0.13616486887204 no 2911 0.122748642542013 967 1124498
SGTC_2831 7999036 19.48 µM -1.16210381381021 0.13601132887843 no 2912 0.122596649231672 989 2988270
SGTC_1792 st045773 43.6 µM -1.16226642657812 0.135977971479494 no 2913 0.122563629805576 908 2919270
SGTC_1830 st055982 50.3 µM -1.16301687536833 0.13582410152764 no 2914 0.122411327852259 980 455313 An antimicrobial agent.
SGTC_1795 st049545 62.3 µM -1.1638175210072 0.13566007086691 no 2915 0.122248985053957 917 5291882
SGTC_3149 9097855 49.47 µM -1.16556894986714 0.135301723666534 no 2916 0.121894383927195 951 25236625 YMR079W SEC14
SGTC_1529 apigenin 74 µM -1.16670067803254 0.135070514347376 no 2917 0.121665634459487 968 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_850 0388-0143 75.9 µM -1.16933937678417 0.134532487394928 no 2918 0.121133462133573 976 67273
SGTC_964 1287-0107 19.4 µM -1.16973620971636 0.134451701157313 no 2919 0.121053570789637 970 51516812 YPR165W RHO1
SGTC_607 4491-0986 66.8 µM -1.17131564706531 0.134130493448682 no 2920 0.120735962133103 925 698981 YDR232W HEM1
SGTC_735 3076-0345 636 µM -1.17597954956926 0.133185081171149 no 2921 0.119801524122666 959 2888990
SGTC_798 1287-0182 476 µM -1.17651044937821 0.133077754743193 no 2922 0.119695479641297 993 1649755
SGTC_3025 9087895 49.47 µM -1.1772907996612 0.13292010762058 no 2923 0.119539728912614 969 17173641
SGTC_247 mechlorethamine 29.705 µM -1.17901864479374 0.132571504344799 no 2924 0.119195375819891 952 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1320 1313-0481 95.3 µM -1.17975938538458 0.132422248489326 no 2925 0.119047963621196 958 6813365 YLR208W SEC13
SGTC_1725 st036284 20.55 µM -1.18664531247644 0.131040306889293 no 2926 0.117683777319772 962 707914
SGTC_1249 0481-0015 10.2 µM -1.18831516285346 0.130706689938517 no 2927 0.117354633050255 957 4227577
SGTC_435 c-PAF 6.7 µM -1.19503372183677 0.129370335135616 no 2928 0.116036927554664 959 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1560 lithocholic acid 53.1 µM -1.19625332042731 0.129128769920792 no 2929 0.115798859437798 938 9903 A bile acid which acts as a detergent.
SGTC_1677 st019204 53.9 µM -1.19650811904512 0.129078341617212 no 2930 0.115749166066309 964 3945625
SGTC_2355 9061122 103.12 µM -1.19732467397118 0.128916825682888 no 2931 0.115590015417731 998 5302957
SGTC_3090 9117696 49.47 µM -1.19755918868129 0.128870464200876 no 2932 0.115544336074213 947 7923821
SGTC_2109 5483026 200 µM -1.19837675953254 0.12870892812257 no 2933 0.115385187942797 977 759335
SGTC_1260 0700-1617 7.75 µM -1.20117126778696 0.12815784872624 no 2934 0.114842386166526 952 2853078
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.20307862027559 0.127782659455339 no 2935 0.114472948964657 946 6708739 YPR165W RHO1
SGTC_647 0140-0236 81 µM -1.20364689351163 0.12767102397588 no 2936 0.114363043249544 994 990837
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.20432761087203 0.127537388472998 no 2937 0.114231489434521 999 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_184 1494-0393 24.714 µM -1.20906918649489 0.126609240914616 no 2938 0.113318133048356 979 3090647
SGTC_1427 4048-4900 550 nM -1.21334319980611 0.125776657687934 no 2939 0.112499316428473 971 24132586
SGTC_1125 tnp00248 1.32998 µM -1.21403790026244 0.125641690814528 no 2940 0.112366625861261 968 24207736
SGTC_2517 totarol 10 µM -1.21534083111819 0.125388829087609 no 2941 0.112118062476329 959 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1971 st069429 63.5 µM -1.21799660775901 0.124874519076519 no 2942 0.111612630919411 957 1246522 YGL099W LSG1
SGTC_2518 prenyletin 46.28 µM -1.21846167142305 0.124784608061582 no 2943 0.111524290773223 965 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_219 mitoxanthrone 164.414 µM -1.21889293130269 0.124701272785006 no 2944 0.111442416471484 990 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2491 paeonol 100 µM -1.22064906655647 0.124362324561131 no 2945 0.111109460028495 1009 11092 Increases levels of cortical cytochrome oxidase.
SGTC_612 0302-0167 22.4 µM -1.22347246561705 0.123818737414753 no 2946 0.110575648864253 980 235821
SGTC_625 k213-0058 121 µM -1.22387988934041 0.123740433929755 no 2947 0.110498770575187 982 3655420
SGTC_325 2810-4341 181 µM -1.22404193336511 0.123709300041141 no 2948 0.110468204541971 951 774970
SGTC_2516 gossypol 71.55 µM -1.23078998946313 0.12241764788596 no 2949 0.109200710273377 986 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_865 0488-0499 301 µM -1.23476095331604 0.121662000177883 no 2950 0.108459741668979 959 9634651
SGTC_1128 3448-9350 235 µM -1.23554934215668 0.121512365919164 no 2951 0.108313062338065 969 619386
SGTC_858 0438-0351 2.77 µM -1.23586275529373 0.121452916829312 no 2952 0.10825479166124 980 2799119
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.24001151869266 0.120667893999601 no 2953 0.107485566854099 955 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2225 6654152 15.4 µM -1.24098941200498 0.120483379870709 no 2954 0.107304830138476 951 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_747 3448-8087 38.7 µM -1.24560953513456 0.119614317574795 no 2955 0.106453889988645 1006 5168703
SGTC_939 1165-0479 45.3 µM -1.24730599933831 0.119296318909247 no 2956 0.106142659258594 957 1377347
SGTC_2164 5685496 200 µM -1.25040396302953 0.118717152670842 no 2957 0.105576008816475 998 759046
SGTC_1257 0669-0121 16 µM -1.25161392937055 0.118491489017021 no 2958 0.105355288220424 970 4307855
SGTC_3316 9136639 10.545 µM -1.25242108584078 0.118341119722299 no 2959 0.105208233450303 964 4903665
SGTC_2327 6189656 200 µM -1.25248398084649 0.118329408358975 no 2960 0.105196780933055 991 5349088
SGTC_1225 1216-0074 20.6 µM -1.25367943993318 0.11810696370279 no 2961 0.104979271944178 988 4241466
SGTC_2641 levomentholum 100 µM -1.25484510628315 0.117890347661522 no 2962 0.104767497291326 984 16666
SGTC_113 0099-0221 2.5 µM -1.25716186900566 0.117460657970947 no 2963 0.104347513832206 972 89219
SGTC_270 tamoxifen 5.46 µM -1.2576903156376 0.117362802555603 no 2964 0.104251887989501 1022 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.25903213083558 0.117114590589197 no 2965 0.10400936327319 958 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1647 st011722 22.4 µM -1.25925005443508 0.117074313729131 no 2966 0.103970013592401 972 2854783
SGTC_1143 3454-2408 5.08 µM -1.25948204808441 0.11703144721483 no 2967 0.103928135198289 943 X1143
SGTC_2837 9008476 45.46 µM -1.25976407173476 0.116979351411041 no 2968 0.103877242102275 979 2992805
SGTC_1088 bifonazole 369 nM -1.26082555085552 0.116783420839245 no 2969 0.103685852988588 986 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1330 1469-0054 61.8 µM -1.26277754507602 0.116423724189699 no 2970 0.103334568363083 979 7102664
SGTC_1304 1165-0502 251 µM -1.26740934603672 0.115573362654525 no 2971 0.102504479849153 979 767425
SGTC_1392 3455-1037 33.9 µM -1.26882495800391 0.115314350240985 no 2972 0.102251750749128 968 981132
SGTC_3107 9121808 49.47 µM -1.26894004010242 0.115293311989355 no 2973 0.102231225088471 926 662681
SGTC_3244 9134489 49.47 µM -1.26948902081503 0.115192989930615 no 2974 0.102133351961094 1000 16584271
SGTC_945 3381-0768 11.3 µM -1.26971925951566 0.115150934032684 no 2975 0.102092324946947 992 1126236 YIL048W NEO1
SGTC_1946 st076057 65.1 µM -1.27278745731521 0.114591532233637 no 2976 0.1015467365771 982 953009
SGTC_2608 thymoquinone 42.66 µM -1.27625870463859 0.113960980426679 no 2977 0.100932041395135 992 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1877 wortmannin 25 µM -1.27958927427307 0.113358310305606 no 2978 0.100344812004779 989 312145 A covalent inhibitor of PI 3-kinase.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.28073173417992 0.113152105532439 no 2979 0.100143954631014 999 368090
SGTC_1494 4358-1428 177 µM -1.28337094230439 0.112676773439443 no 2980 0.0996810745413441 979 1564571
SGTC_67 0335-0847 266 µM -1.28417103951528 0.11253295475592 no 2981 0.0995410579760096 1004 4552207 YOR254C SEC63
SGTC_739 1486-1183 203 µM -1.28854898360571 0.111748334175467 no 2982 0.0987774645692382 984 4346692
SGTC_2545 solidagenone 89.61 µM -1.28870013604209 0.111721314508516 no 2983 0.098751177591347 940 6708572 An anti ulcer agent
SGTC_2839 9003951 25.97 µM -1.28940169153768 0.111595967220785 no 2984 0.0986292368308013 966 2990634
SGTC_322 k048-0136 19.3 µM -1.29322522491724 0.110914583008188 no 2985 0.0979665868673018 1003 6823282
SGTC_391 gliotoxin 8.33 µM -1.29423597790713 0.11073495784679 no 2986 0.0977919614988453 987 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1527 coumarin 137 µM -1.29564208586811 0.110485419340056 no 2987 0.0975494112672008 1011 323 A hepatotoxic, DNA x-linker.
SGTC_3178 9107506 49.47 µM -1.29630126309104 0.110368575679766 no 2988 0.0974358567994393 986 8897194
SGTC_3283 9109332 35.8195 µM -1.29638257105542 0.110354169429188 no 2989 0.0974218568424346 963 17027281
SGTC_959 1222-0044 107 µM -1.29680818634704 0.110278780362472 no 2990 0.0973485966377831 964 6083612
SGTC_687 k029-0044 34.9 µM -1.29947982893786 0.109806396894209 no 2991 0.0968896557104894 1001 5829338
SGTC_3162 9099653 49.47 µM -1.29987211762346 0.109737157282711 no 2992 0.0968224014301218 975 25237511
SGTC_1658 st012944 20 µM -1.30103643947603 0.109531837090334 no 2993 0.0966229910453532 995 24207260
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.30163798841985 0.109425866196772 no 2994 0.096520083588546 990 5377381
SGTC_705 1124-0212 310 µM -1.30373073230433 0.109057775121085 no 2995 0.0961627035783731 977 9554485
SGTC_708 3448-5400 146 µM -1.30559260871966 0.108731039935828 no 2996 0.0958455676067146 1005 3462195
SGTC_84 0443-0269 128.823 µM -1.30645733058301 0.108579532076245 no 2997 0.095698540232576 962 6150058
SGTC_222 nsc-310342 10.666 µM -1.31056046374156 0.107862692154527 no 2998 0.0950031519668617 994 432556
SGTC_2104 5389443 200 µM -1.31243576340082 0.107536204349053 no 2999 0.0946865733310019 1009 2244536
SGTC_2950 9072895 21.46 µM -1.31422454172774 0.107225444029358 no 3000 0.0943853259817766 971 17332245
SGTC_2724 maprotiline 69.64 µM -1.31463393846382 0.107154411630061 no 3001 0.0943164791602425 972 4011 A tricyclic antidepressant.
SGTC_3354 9151612 71.43 µM -1.31568002288585 0.106973064847629 no 3002 0.0941407310270097 980 27261949
SGTC_686 1319-0111 510 µM -1.31860993863285 0.106466320075271 no 3003 0.0936497746759561 994 4562600
SGTC_863 0466-0191 129 µM -1.31876325377421 0.106439851192952 no 3004 0.0936241363113154 1001 765160 YPR165W RHO1
SGTC_665 3914-0008 307 µM -1.31887044121773 0.106421348786077 no 3005 0.0936062148018248 998 1069549
SGTC_1393 3470-5649 58.2 µM -1.32488496570031 0.10538685611032 no 3006 0.0926046540322377 982 4108395
SGTC_2456 5770359 74.46 µM -1.32567547429962 0.105251432089448 no 3007 0.0924736072742596 1000 3118787
SGTC_535 2293-4129 48.2 µM -1.32777727891252 0.104891979187834 no 3008 0.0921258475611553 1018 396118 YIL048W NEO1
SGTC_1289 0976-0073 69.1 µM -1.32818105219566 0.104823027335937 no 3009 0.0920591511810621 999 3391136
SGTC_3010 9080089 71.4286 µM -1.32874784677652 0.104726291924103 no 3010 0.0919655868224322 993 17027233
SGTC_2045 5106652 78.05 µM -1.33013119243676 0.10449046639367 no 3011 0.0917375249310899 971 673349
SGTC_2391 6285546 200 µM -1.33028390141336 0.104464456965574 no 3012 0.0917123746416528 1000 846083
SGTC_2175 5807670 165.306 µM -1.33036618721407 0.104450443973979 no 3013 0.091698824761977 957 241186
SGTC_1939 st074455 53.6 µM -1.33040146383013 0.10444443690354 no 3014 0.0916930162686392 1004 1644229
SGTC_182 3448-4371 550.524 µM -1.33095559578353 0.104350109518552 no 3015 0.0916018110932434 976 3491403
SGTC_1058 3448-5425 97.3 µM -1.33109146600108 0.104326990371262 no 3016 0.0915794583334331 999 7279705
SGTC_710 3448-4187 58 µM -1.3333869950581 0.10393695309534 no 3017 0.0912024189772322 984 3946412
SGTC_2747 doxorubicin 7.63 µM -1.33839153789997 0.103090290851095 no 3018 0.0903844179709993 945 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_412 gemfibrozil 100 µM -1.34037424859356 0.102756247463388 no 3019 0.0900618517169461 991 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_127 0180-0333 59.125 µM -1.34175509803476 0.102524069665192 no 3020 0.0898377077786613 931 771601
SGTC_1121 fusaric acid 630.51 nM -1.34395096757067 0.102155639230082 no 3021 0.0894821215110743 993 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_822 1487-0950 154 µM -1.34430025020335 0.102097124306315 no 3022 0.0894256573525269 973 1958375
SGTC_1916 st067606 49.2 µM -1.3443625881562 0.102086683464721 no 3023 0.089415582742299 960 19590279
SGTC_285 1486-1325 46 µM -1.34513468501543 0.10195743111373 no 3024 0.0892908719934601 990 22310230
SGTC_546 peri-Naphthalide 147 µM -1.34533019097118 0.101924721475851 no 3025 0.0892593139924342 987 223824 A penicillin ester.
SGTC_1124 fisetin 1.16336 µM -1.34629646281612 0.101763168972888 no 3026 0.0891034630660093 999 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_294 k038-0071 157 µM -1.34910219997919 0.101295130024143 no 3027 0.0886520708693387 1004 24152826
SGTC_1045 1348-1485 165 µM -1.35324585286448 0.100606778229988 no 3028 0.0879885505685108 1013 6810614
SGTC_2290 7904846 200 µM -1.35548379302792 0.100236429338531 no 3029 0.0876317343853839 986 2962154
SGTC_2426 5582046 32.21 µM -1.35594181528664 0.100160755666792 no 3030 0.087558840799268 990 2251934
SGTC_3100 9120536 49.47 µM -1.35902030138738 0.0996532153317381 no 3031 0.0870700778443835 987 16421196
SGTC_2077 5212015 200 µM -1.3591932474543 0.0996247581094918 no 3032 0.0870426802380451 982 780900
SGTC_2084 5306078 60.6385 µM -1.36121402058762 0.0992926921366417 no 3033 0.0867230323292945 1014 679340
SGTC_1895 st058434 18.3 µM -1.36247952576912 0.0990851489796727 no 3034 0.0865233006461738 1023 5393175
SGTC_107 0358-0022 2.6945 µM -1.36251233878271 0.0990797718608178 no 3035 0.0865181264237243 1023 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3177 9107506 49.47 µM -1.36406520241812 0.0988255457094266 no 3036 0.0862735227043388 1002 8897194
SGTC_2649 anisomycin 9.56 µM -1.36662818674909 0.0984069928392425 no 3037 0.0858709388061223 1008 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2374 9071832 200 µM -1.37248821407924 0.0974548901781502 no 3038 0.0849557527048144 995 17381698
SGTC_2353 9059630 146.67 µM -1.37306597852292 0.0973613856128433 no 3039 0.0848659181903386 1014 4779114
SGTC_1524 corynanthine 62.1 µM -1.37409922053181 0.0971943313387666 no 3040 0.0847054407062334 1014 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1056 3448-1962 115 µM -1.37732273198838 0.0966745067914995 no 3041 0.0842062450742584 988 715507
SGTC_1115 galangin 695.678 nM -1.38229023822948 0.095877447602484 no 3042 0.0834413010511356 1020 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1503 4585-0012 61.3 µM -1.38303788183437 0.0957579044457406 no 3043 0.0833266253749552 1019 2922052
SGTC_744 1594-0068 283 µM -1.38598397626937 0.0952879111682347 no 3044 0.0828758982130685 1020 668392
SGTC_1057 3448-5381 134 µM -1.38647043436696 0.0952104696947829 no 3045 0.0828016510691584 952 5497911
SGTC_1760 st045453 10.4495 µM -1.38668886477093 0.0951757118478742 no 3046 0.0827683287521539 1010 3323419 YIL048W NEO1
SGTC_2771 fluoxetine 41.05 µM -1.38734828169531 0.0950708384866894 no 3047 0.082667793622127 994 3386 A selective serotonin reuptake inhibitor.
SGTC_990 3985-0011 41.3 µM -1.389854479915 0.0946730303395715 no 3048 0.0822865353432791 994 5399565 YGL099W LSG1
SGTC_2219 9098279 200 µM -1.39527016698413 0.0938175924118561 no 3049 0.0814671923952158 1000 902349
SGTC_419 nsc-638432 893 µM -1.39532055006608 0.0938096609991098 no 3050 0.0814595988973179 1004 368090
SGTC_2845 9003024 42.97 µM -1.39650079444949 0.0936240059756372 no 3051 0.0812818707678776 993 2990173
SGTC_2481 5478948 45.16 µM -1.39740698998217 0.0934816436653386 no 3052 0.0811456091752604 1009 77792
SGTC_2246 7293507 91.5585 µM -1.39813935320062 0.093366707088673 no 3053 0.0810356121679166 1008 887656
SGTC_2220 6782180 200 µM -1.3993853952927 0.0931713940674679 no 3054 0.0808487220350496 996 833803
SGTC_566 0958-0068 16.5 µM -1.40370997315531 0.0924958730186657 no 3055 0.0802026157144218 990 6815365
SGTC_3234 9132280 49.47 µM -1.40393233064412 0.0924612378534206 no 3056 0.0801695005620827 1001 17612295
SGTC_411 enrofloxacin 100 µM -1.40461496590077 0.0923549681943714 no 3057 0.0800679019441817 1004 71188 A bacterial gyrase inhibitor.
SGTC_2886 9058944 51.95 µM -1.41001498645113 0.0915175005669336 no 3058 0.0792676288995427 992 4949929
SGTC_3183 9108214 49.47 µM -1.41044542918478 0.091450987903125 no 3059 0.0792040996039746 1009 4974831
SGTC_3062 9077494 49.47 µM -1.4129839153614 0.0910594657358378 no 3060 0.0788302267547325 884 16459633
SGTC_431 k089-0097 107 µM -1.4169398657062 0.0904518021598096 no 3061 0.0782502548366892 957 5499420
SGTC_1138 3761-0006 1.03 µM -1.41722071953498 0.0904087756516715 no 3062 0.0782092029192786 1013 12061087
SGTC_587 k089-0003 57 µM -1.41736968778689 0.0903859600430282 no 3063 0.0781874351189361 985 9659696
SGTC_2977 9011197 71.43 µM -1.41781727481817 0.0903174344436625 no 3064 0.0781220596668122 991 2704722
SGTC_2277 7947813 106.88 µM -1.42004998776436 0.0899761821607328 no 3065 0.077796564359361 1013 1246798
SGTC_3157 9099274 49.47 µM -1.42550669180559 0.0891462024936512 no 3066 0.0770053935650117 1003 17217662
SGTC_1043 0916-0009 19.3 µM -1.42560682744252 0.0891310250047747 no 3067 0.0769909321934254 1019 3101130
SGTC_3246 9135460 32.98 µM -1.4369384598668 0.0874258931254429 no 3068 0.0753677402746729 1010 41446951
SGTC_72 0744-0168 198.391 µM -1.44064708284745 0.086873158590886 no 3069 0.0748422058571072 1027 677577
SGTC_605 1315-0399 119 µM -1.44663838587544 0.0859857348629246 no 3070 0.0739991146738554 1018 24020461
SGTC_2644 guaiazulene 100 µM -1.45261909217504 0.0851066634227812 no 3071 0.0731647710653751 997 3515 A coloring agent.
SGTC_1796 st049173 110.4 µM -1.45566476456976 0.0846615930705299 no 3072 0.0727426574541607 1007 94134
SGTC_2321 7390090 138.78 µM -1.46347418673252 0.083528365339336 no 3073 0.0716688359486652 1033 649046
SGTC_2804 7954240 19.48 µM -1.46472023839187 0.083348609830071 no 3074 0.0714986304750545 1004 828705
SGTC_85 0868-0259 160.055 µM -1.46524719728304 0.0832726782506874 no 3075 0.0714267434799629 994 83173
SGTC_1997 st073024 93.8 µM -1.46670704670087 0.0830625944171157 no 3076 0.0712278825614088 1024 686268
SGTC_2785 7756463 72.73 µM -1.47070934825701 0.0824886763297659 no 3077 0.0706848684985347 1014 2201551
SGTC_3073 9114972 49.47 µM -1.47136325616837 0.0823951922948348 no 3078 0.0705964523950159 1014 41905075
SGTC_631 k072-0230 41.5 µM -1.4732964253445 0.0821192889287756 no 3079 0.0703355620815675 1024 5773147
SGTC_2752 diclazuril 33.15 µM -1.47352228727965 0.0820870992033622 no 3080 0.0703051293778672 997 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_875 0709-0210 25.7 µM -1.47826347666588 0.0814135795998767 no 3081 0.0696686347489967 1026 6251364
SGTC_1422 4031-0024 15.5 µM -1.47955246186566 0.0812311927140706 no 3082 0.0694963604997871 1033 782427
SGTC_3190 9110366 49.47 µM -1.47966979227357 0.0812146061925522 no 3083 0.0694806954691876 1018 17123768
SGTC_2983 9022671 12.99 µM -1.48452532351236 0.0805304383603377 no 3084 0.0688348050546679 1006 6405161
SGTC_1790 st045711 43.5 µM -1.48782242661004 0.0800683485097318 no 3085 0.0683988648304383 989 585119
SGTC_2741 miltefosine 3.04 µM -1.49215175694075 0.0794646394711215 no 3086 0.0678296830800796 1011 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_534 k292-0788 63.4 µM -1.49232892670109 0.079440007379993 no 3087 0.0678064685304704 1024 4146317
SGTC_1876 myriocin 605 nM -1.49263310343412 0.079397730858803 no 3088 0.0677666265726935 1016 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_291 SEC14.278 35.5 µM -1.49343940434172 0.0792857481534863 no 3089 0.0676611024181521 1020 1068044
SGTC_135 0933-0004 26.348 µM -1.49382586306798 0.0792321174294611 no 3090 0.067610569886193 1003 21230617 YGL099W LSG1
SGTC_831 k061-1017 217 µM -1.49409081905173 0.0791953640948421 no 3091 0.0675759416501071 1052 1240153
SGTC_2968 9090663 33.37 µM -1.49506633963659 0.0790601561357098 no 3092 0.0674485647750118 982 25236811
SGTC_2101 5377231 179.231 µM -1.49511484562196 0.0790534377312907 no 3093 0.0674422360377804 1033 2844213
SGTC_2748 diazoxide 86.69 µM -1.4960622746372 0.0789222991413015 no 3094 0.0673187138301637 996 3019 A potassium channel activatior.
SGTC_2744 captopril 92.04 µM -1.49658796779248 0.0788496063308913 no 3095 0.0672502514270868 1036 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2009 4012297 12.05 µM -1.49844215012646 0.0785936150932182 no 3096 0.0670092060851901 997 45595307
SGTC_599 1935-0052 86.5 µM -1.49856952394774 0.0785760528192746 no 3097 0.0669926719369361 1025 9557311
SGTC_3136 9095672 49.47 µM -1.49967619809022 0.0784235900110576 no 3098 0.0668491494993155 1002 17217380
SGTC_414 piperonyl butoxide 100 µM -1.50355276695247 0.0778912966421495 no 3099 0.0663482803174256 1032 5794 A potent inhibitor of cytochrome P450.
SGTC_284 0988-0104 32.6 µM -1.50531031983688 0.0776508715010843 no 3100 0.0661221566141966 1012 4666532
SGTC_280 3448-3607 3.04 µM -1.50858001493866 0.0772050919095806 no 3101 0.0657030722766236 1002 626179
SGTC_350 k064-0020 19.8 µM -1.50966254187464 0.0770579329506212 no 3102 0.0655647769626021 972 2790705
SGTC_2483 5729050 27.16 µM -1.51070607361039 0.0769162768923377 no 3103 0.065431677146723 1021 2865180
SGTC_417 st075190 100 µM -1.51179348025337 0.0767688756588284 no 3104 0.065293204265965 1031 222757
SGTC_3024 9090631 49.47 µM -1.51888434077879 0.0758129502507249 no 3105 0.0643958056426513 1007 25236383
SGTC_1190 1486-1332 13 µM -1.52278915649388 0.075290423635339 no 3106 0.0639057318573326 1012 4150046
SGTC_502 l-744,832 89.3 µM -1.52463442554521 0.0750444544749913 no 3107 0.0636751529312379 1032 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_844 0330-0132 15.3 µM -1.52640757295512 0.0748086767587834 no 3108 0.063454196414521 1022 2828079
SGTC_2145 5634607 200 µM -1.52809099617319 0.0745853531920402 no 3109 0.0632449733317106 1034 308662
SGTC_1646 st011709 75.6 µM -1.52940831648537 0.0744109521456599 no 3110 0.0630816260179411 1032 5757843
SGTC_1327 1436-0082 2.18 µM -1.5295926931662 0.0743865672341782 no 3111 0.0630587896028496 1023 15992205
SGTC_2493 resveratrol 26.09 µM -1.53035974662238 0.074285185345122 no 3112 0.062963853470256 1008 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1169 aniline yellow 25.8 µM -1.53076053027805 0.074232255529442 no 3113 0.0629142938657433 1019 6051 A DNA damaging agent.
SGTC_3105 9121040 49.47 µM -1.53384665028492 0.0738256489635233 no 3114 0.0625336916505917 992 41448907
SGTC_1934 st074720 32.6 µM -1.53455252143081 0.0737328877268444 no 3115 0.0624468913557706 1010 17250992
SGTC_2018 5133068 143 µM -1.54218922786112 0.0727350070698869 no 3116 0.0615138084957054 1020 785362
SGTC_2412 st077135 33.4 µM -1.54293968709013 0.0726375060767204 no 3117 0.0614227051735312 1034 13258915
SGTC_2114 5491910 81.25 µM -1.54403576457955 0.0724952816486975 no 3118 0.0612898343342522 1026 2849228
SGTC_1815 st051655 58.2 µM -1.54577847958133 0.0722695904233289 no 3119 0.0610790380570173 1015 5984156
SGTC_898 1000-0849 28.3 µM -1.54700571359877 0.0721109802119096 no 3120 0.0609309339509741 1031 6751807
SGTC_2873 9040596 71.43 µM -1.55334278580807 0.0712962074990944 no 3121 0.0601706318494049 1036 6463863
SGTC_2141 5621638 7.665 µM -1.55461464333262 0.0711335365184064 no 3122 0.0600189370857315 1034 2856238
SGTC_1515 3460-0031 42.1 µM -1.56244284149459 0.0701385760576713 no 3123 0.0590918506183381 1018 2876596
SGTC_2196 6573537 42.6665 µM -1.56291187602023 0.070079303621952 no 3124 0.0590366619528185 1046 2903087
SGTC_761 k216-0224 480 µM -1.56321556907824 0.0700409461359765 no 3125 0.0590009496628736 1052 1340404
SGTC_2546 rhodinyl acetate 100 µM -1.56464229045681 0.069860962428746 no 3126 0.0588334034703705 1005 6708682
SGTC_2 0422-0095 29 µM -1.56728351152415 0.0695287068498456 no 3127 0.0585242188423983 1007 6790840
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.56782516748273 0.0694607191886197 no 3128 0.0584609698486679 996 88881 An O-methylated flavonoid and antioxidant.
SGTC_692 k241-0027 77.8 µM -1.57484110027933 0.0685847121281441 no 3129 0.0576465634306469 1024 3600480
SGTC_39 0986-0283 58.349 µM -1.57779656297548 0.0682182549179875 no 3130 0.0573061768491714 1020 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.57893443366767 0.0680775703133637 no 3131 0.0571755484421188 1032 688664
SGTC_3176 9106582 49.47 µM -1.58166473457683 0.0677409136105698 no 3132 0.0568630636979477 1028 17018027
SGTC_1798 st045719 60.953 µM -1.58669158620375 0.0671244485736456 no 3133 0.0562912564346374 1003 3980186
SGTC_1626 st003712 1.76 µM -1.58922222165291 0.06681575172773 no 3134 0.0560051156269279 1023 24207035
SGTC_2754 granisetron 64.02 µM -1.58994272767949 0.0667280627635921 no 3135 0.0559238576448147 1039 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3323 9138564 53.9225 µM -1.59033686957387 0.0666801315428204 no 3136 0.0558794460682194 1022 43912313 YNL103W MET4
SGTC_1082 camptothecin 424.86 nM -1.59252260179282 0.0664148101627699 no 3137 0.0556336643953717 984 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1746 st038117 42 µM -1.59703679027419 0.0658694305523411 no 3138 0.0551287533080284 1031 2898218
SGTC_3139 9095020 49.47 µM -1.59874077053575 0.0656644696497794 no 3139 0.0549391072464431 1009 25236292
SGTC_859 0439-0102 54.6 µM -1.60285283568915 0.0651718920433734 no 3140 0.0544835743124836 1026 610143
SGTC_2281 7943571 200 µM -1.60625957301837 0.0647659802501269 no 3141 0.0541084444600917 1033 1244024
SGTC_218 alverine citrate 93.75 µM -1.60693866743763 0.064685301509416 no 3142 0.0540339115104366 1023 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3094 9117742 49.47 µM -1.60970257774547 0.0643577445721424 no 3143 0.0537314009783908 1039 17149698
SGTC_220 paclitaxel 373.376 µM -1.61265840808867 0.0640088706097686 no 3144 0.0534093706773394 1022 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1008 4106-0037 6 µM -1.61708933731433 0.0634886486890381 no 3145 0.0529294990772871 1024 2905394
SGTC_2768 sulfasalazine 50.2 µM -1.62013805376536 0.063132623273911 no 3146 0.0526013122991821 1043 5384001 An antioxidant and salicylic acid derivative.
SGTC_1191 1487-1166 10.6 µM -1.62905649076192 0.0621000622755719 no 3147 0.0516505303630339 1060 3955771
SGTC_46 0329-0187a 2.197 µM -1.6307411262725 0.0619065059359888 no 3148 0.0514724773904379 1034 46494817
SGTC_2287 7945887 168.79 µM -1.63127173745373 0.061845638922838 no 3149 0.051416497081087 1029 1245853
SGTC_1012 4112-3522 18 µM -1.63787305933275 0.0610922935108094 no 3150 0.0507240884890906 1034 3112398
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.64246917229481 0.0605720322309069 no 3151 0.0502464049185958 1004 4000243
SGTC_2905 7799065 20.05 µM -1.64770522999307 0.0599835624566205 no 3152 0.0497065871522869 1000 1296806
SGTC_2144 5628481 200 µM -1.65294660508402 0.0593989886186192 no 3153 0.0491708654642474 1028 2818399
SGTC_2650 prasterone 100 µM -1.65558264481973 0.0591066822098403 no 3154 0.0489031835965249 1041 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1622 st003707 19.4 µM -1.65680309360017 0.0589717311890724 no 3155 0.04877964568463 1008 10140899
SGTC_2126 5251174 33.877 µM -1.65686366658205 0.0589650396384888 no 3156 0.0487735207873087 1041 790722
SGTC_1648 st011736 69.8 µM -1.65847776358993 0.058786948264407 no 3157 0.0486105360585624 1046 2855514
SGTC_1793 st048256 72.231 µM -1.66393285153887 0.0581881839360979 no 3158 0.0480629245375053 1020 672022
SGTC_3012 9080433 71.4286 µM -1.66462295638924 0.0581127789086309 no 3159 0.0479940012180628 1023 17688859
SGTC_2079 5212404 121 µM -1.66996946138922 0.0575311863297184 no 3160 0.0474627029264313 1034 758462
SGTC_163 TUB2.036 7.546 µM -1.67085312918743 0.0574355033989717 no 3161 0.0473753456988908 1013 15992207 YJR013W GPI14
SGTC_1208 2323-2347 50.3 µM -1.6716175838068 0.0573528298258681 no 3162 0.0472998775750911 1037 5412760
SGTC_2810 7959871 45.46 µM -1.67403983275032 0.0570914888295916 no 3163 0.0470613855991455 1025 2974535
SGTC_2682 pyrogallin 40.03 µM -1.67772040361103 0.0566961806047583 no 3164 0.0467008471714126 1037 822798 An ATP competetive kinase inhibitor.
SGTC_265 mycophenolic acid 32.932 µM -1.68240411839486 0.0561962521535743 no 3165 0.0462452516672362 1069 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_720 r052-1644 49.9 µM -1.68584822069948 0.055830859548331 no 3166 0.0459125186337618 1045 1422863 YOR257W CDC31
SGTC_80 0159-0065 512.242 µM -1.6878749382829 0.0556167181617841 no 3167 0.0457176192201505 1033 1548079
SGTC_888 0916-0002 6.97 µM -1.69609966596729 0.0547543463969805 no 3168 0.0449335034552016 1054 2802138 YIL048W NEO1
SGTC_996 3970-0799 1.8 µM -1.69973840143345 0.0543762095183257 no 3169 0.0445900713336163 1030 6615648 YGL040C HEM2
SGTC_2073 5212005 126 µM -1.70034910440588 0.0543129482858273 no 3170 0.0445326395528092 1028 691789
SGTC_2795 7780010 54.55 µM -1.70240676947539 0.0541002282987074 no 3171 0.0443395709624129 1023 953673
SGTC_2356 9061756 188.97 µM -1.70747709536693 0.0535788755019432 no 3172 0.0438667057494768 1046 20104043
SGTC_2278 7948257 134.34 µM -1.71390658003408 0.0529235008555168 no 3173 0.0432729422018526 1037 1247028
SGTC_2273 7815444 169.05 µM -1.71994903821588 0.0523133880736937 no 3174 0.0427208527569341 1042 2824616
SGTC_2208 7283366 200 µM -1.7208944942214 0.0522184317938639 no 3175 0.0426349854321805 1040 898663
SGTC_3086 9117350 49.47 µM -1.72091467734235 0.0522164062080518 no 3176 0.0426331539019144 1031 2679265
SGTC_827 3253-0474 693 µM -1.72213737781071 0.0520938118710495 no 3177 0.0425223177671133 1050 5402065
SGTC_2398 5228213 48.84 µM -1.72356789012686 0.0519506715866047 no 3178 0.042392939688787 1047 80771 YMR134W ERG29
SGTC_2450 5739737 12.93 µM -1.72654675181208 0.051653603013593 no 3179 0.0421245480268765 1039 2262825
SGTC_1880 MG-132 525 µM -1.72800440994395 0.051508730200202 no 3180 0.0419937168738211 1017 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2790 5423970 71.43 µM -1.73372490808833 0.0509433046790305 no 3181 0.0414834524226474 1033 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_56 0957-0365 83.25 µM -1.73928966192314 0.0503980250641842 no 3182 0.0409919124225318 1044 6752360
SGTC_1086 cerivastatin 2.18 µM -1.74352762096912 0.0499858833142443 no 3183 0.0406207469299439 1026 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_938 3126-1755 342 µM -1.74543411676305 0.0498013551209472 no 3184 0.0404546656679875 1036 1777771
SGTC_882 0843-0131 351 µM -1.74772015725486 0.0495808079968504 no 3185 0.0402562483215462 1051 5425421
SGTC_2096 5468907 200 µM -1.75082428193897 0.0492825842496863 no 3186 0.0399880913043383 1057 759785
SGTC_2302 7771753 200 µM -1.76317362122184 0.0481102995386479 no 3187 0.038935605674671 1029 2203047
SGTC_1174 0739-0097 51.1 µM -1.76463651343836 0.0479729223663817 no 3188 0.0388124373593514 1050 728447
SGTC_3338 9144300 39.5675 µM -1.77293373156063 0.0471996784251018 no 3189 0.0381198442108673 1031 4901274
SGTC_1590 st077108 57.8 µM -1.78881250242939 0.0457477577203077 no 3190 0.0368225083789083 1055 5489485
SGTC_1328 1441-0025 69.2 µM -1.79283714321108 0.0453855137470366 no 3191 0.0364994842178651 1047 4562601
SGTC_458 nppb 133 µM -1.79322160441382 0.0453510307832584 no 3192 0.0364687484456965 1059 4549 A chloride channel blocker.
SGTC_2852 9023854 51.95 µM -1.795401241514 0.0451559337292459 no 3193 0.0362948974059773 1050 19798528
SGTC_1556 plumbagin 1.48 µM -1.80213791403059 0.0445572073087556 no 3194 0.0357618549438513 1001 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1270 0831-1170 17.3 µM -1.80562286433181 0.0442499990801615 no 3195 0.035488634367624 1046 6764716
SGTC_53 0973-0023 39.979 µM -1.80989119967534 0.0438760617829801 no 3196 0.0351563305625577 1045 674768
SGTC_3063 1327-0034 4 µM -1.82224605444822 0.0428080354999388 no 3197 0.0342088297282122 1037 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_450 aminopyrene 156 nM -1.82844354495414 0.0422802565044523 no 3198 0.0337415055859158 1050 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2229 7354935 190 µM -1.83259194336387 0.0419299288955819 no 3199 0.0334316385900053 1060 318112
SGTC_2379 9035213 200 µM -1.83387919493431 0.0418217009472584 no 3200 0.0333359642662913 1049 646551
SGTC_2310 7668677 200 µM -1.83406262025115 0.0418062975699008 no 3201 0.0333223496435443 1050 2197143
SGTC_1425 4048-4433 7.33 µM -1.83455700164008 0.0417648041331498 no 3202 0.033285677313854 1075 23734946
SGTC_341 1486-1430 230 µM -1.83768208151195 0.0415032873039371 no 3203 0.0330546328752094 1063 2054753 YPL210C SRP72
SGTC_1412 3909-8563 178 µM -1.85454830805597 0.0401146845297268 no 3204 0.0318303778131083 1069 23767530
SGTC_1167 k781-0610 148 µM -1.85466283606315 0.0401053860405441 no 3205 0.0318221944766174 1040 4525169
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.85567104384166 0.0400236055403953 no 3206 0.0317502302646432 1046 1241132 A phosphatase inhibitor.
SGTC_1475 4092-1048 11.7 µM -1.86026760649224 0.039652472228355 no 3207 0.0314238371029762 1061 2881759
SGTC_1891 st059073 26.2 µM -1.86828922707535 0.0390115011147054 no 3208 0.0308608837082706 1055 688754
SGTC_2066 5222451 176 µM -1.87480121683557 0.0384973839284312 no 3209 0.030410037867259 1003 2281147
SGTC_2447 5741742 33.78 µM -1.87606269661755 0.0383984322481084 no 3210 0.0303233356148721 1056 1776504
SGTC_1350 1495-0454 146 µM -1.87639932576409 0.0383720618106453 no 3211 0.0303002335513375 1061 1069057
SGTC_420 mitomycin C 81.9 mM -1.8779879693785 0.0382478117869426 no 3212 0.0301914054489143 1040 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2843 9000894 45.46 µM -1.88079674660538 0.0380289362997219 no 3213 0.0299997864540872 1045 2242070
SGTC_2373 9071805 200 µM -1.88227278853246 0.0379143251379263 no 3214 0.0298994935879443 1066 10149009
SGTC_229 benomyl 22.8748 µM -1.88248591259963 0.0378977998681151 no 3215 0.0298850354138912 1050 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_529 4076-0302 30.3 µM -1.88994302169649 0.0373232791911352 no 3216 0.0293827904468719 1055 5816522
SGTC_1277 0873-0036 22 µM -1.90065158361395 0.0365107195335472 no 3217 0.0286738320834163 1062 5965735
SGTC_407 eburnamonine 100 µM -1.91153129368498 0.0357000547617243 no 3218 0.0279681696105105 1050 3195
SGTC_3061 glucosamine 200 µM -1.91991322221214 0.0350856145628786 no 3219 0.027434430747115 1050 91431 and experimental redox chemotherapeutic
SGTC_1209 2323-2347 50.3 µM -1.92140169873221 0.0349774138964682 no 3220 0.0273405422778257 1040 5412760
SGTC_2988 9073640 71.4286 µM -1.92429745027438 0.0347676999444431 no 3221 0.0271586550036521 1060 9102229
SGTC_694 1315-0438 43.2 µM -1.92468695381152 0.0347395705492861 no 3222 0.0271342668059993 1063 6793154
SGTC_564 3555-0129 330 µM -1.92554296334057 0.0346778164139424 no 3223 0.0270807332187648 1045 563260
SGTC_965 1291-5240 308 µM -1.92913499575171 0.0344196625874227 no 3224 0.0268570527381519 1061 2834598
SGTC_3263 9137018 49.47 µM -1.92964217435885 0.034383339990534 no 3225 0.0268255946991141 1051 43844957
SGTC_3151 9099821 49.47 µM -1.94935111112751 0.0329960584005581 no 3226 0.0256267543363076 1047 17174189
SGTC_79 0052-0007 94.094 µM -1.9541665552783 0.0326642114575856 no 3227 0.0253407615828891 1052 2801472
SGTC_1007 4101-0031 70 µM -1.97001767594078 0.0315912496277527 no 3228 0.0244181723994782 1074 1146276
SGTC_1540 guanosine 70.6 µM -1.97180767949871 0.0314719360263927 no 3229 0.0243157826764219 1061 6802 Guanosine is a purine nucleoside
SGTC_2217 6934799 96.0675 µM -1.97603633430281 0.031191551862011 no 3230 0.0240753310844858 1065 675606
SGTC_1545 lovastatin 49.4 µM -1.97642498739276 0.0311658859297634 no 3231 0.0240533319124312 1074 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2999 9069765 71.4286 µM -1.98483214215024 0.0306149555836203 no 3232 0.0235815750655073 1044 2097066
SGTC_2177 5811945 192 µM -1.98675106664623 0.030490343404282 no 3233 0.0234749948477416 1055 5343475
SGTC_2340 7987427 183.45 µM -1.99258064961338 0.0301143533982365 no 3234 0.0231536929130777 1060 2239331
SGTC_1808 st050063 61.5 µM -1.9931418914887 0.0300783587692853 no 3235 0.0231229559651388 1063 4011993
SGTC_590 k048-0076 22.4 µM -2.00475264530766 0.0293416823654405 no 3236 0.0224947486672081 1072 6832814
SGTC_2625 euphol 100 µM -2.00512728132114 0.0293181643109906 no 3237 0.0224747208076915 1051 6708538 A triterpene alcohol.
SGTC_2594 a-mangostin 100 µM -2.00721702735634 0.0291872659794247 no 3238 0.0223632796760572 1066 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1908 st060353 56.5 µM -2.0138841775751 0.0287728877262291 no 3239 0.0220108475572246 1062 4227716
SGTC_1586 deoxycorticosterone acetate 53.7 µM -2.02173716417925 0.0282910926147421 no 3240 0.0216017561563483 1079 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3173 9105693 49.47 µM -2.02192594000885 0.0282795940248792 no 3241 0.0215920017386158 1060 17096658
SGTC_63 0099-0242 26.702 µM -2.0368945744373 0.0273801386397149 no 3242 0.0208303039784902 1071 3898502 YLR359W ADE13
SGTC_2565 isoliquiritigenin 100 µM -2.04084682121162 0.027146672485678 no 3243 0.0206330275056914 1043 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3060 1327-0027 12.5 µM -2.04430741090948 0.02694361552596 no 3244 0.0204615937893007 1043 16000455 YPR107C YTH1
SGTC_2722 naftopidil 47.16 µM -2.04798978749145 0.0267289387263178 no 3245 0.020280500038878 1063 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1381 2324-0066 62.1 µM -2.05011163009011 0.0266058886241504 no 3246 0.0201767693714488 1072 10885928
SGTC_973 1325-0077 65.9 µM -2.07015384965738 0.0254667760222273 no 3247 0.019218969728097 1079 2835149
SGTC_490 phenamil 164 µM -2.0759715570747 0.0251438748747282 no 3248 0.0189482908464547 997 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_717 1532-0246 73.2 µM -2.07628086556538 0.0251268037805044 no 3249 0.01893399097443 1069 9561992
SGTC_873 0591-4978 488 µM -2.08102289099289 0.0248662996705182 no 3250 0.018715905429997 1066 3305145
SGTC_1588 farnesol 29.9 µM -2.08878664878969 0.0244446873396354 no 3251 0.0183634663901569 1056 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2746 daunorubicin 9.88 µM -2.08914742024746 0.0244252423744036 no 3252 0.0183472274101346 1082 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2850 9015429 58.44 µM -2.09081340046372 0.0243356172355653 no 3253 0.0182723971952203 1065 6457570
SGTC_1561 5-methoxyflavone 52.9 µM -2.09242472408194 0.0242491953246784 no 3254 0.0182002695121512 1053 94525
SGTC_3166 9102297 49.47 µM -2.09822160394743 0.0239404135105008 no 3255 0.0179427870188576 1068 25237072
SGTC_1220 1838-0075 193 µM -2.11164601590355 0.0232380048362941 no 3256 0.0173584112756231 1054 5529645
SGTC_1451 4152-0210 104 µM -2.113974212031 0.0231179687258505 no 3257 0.0172587349679257 1063 659563
SGTC_622 1348-1566 26.3 µM -2.11737559300963 0.0229435406591259 no 3258 0.0171139919624008 1077 7340407
SGTC_2337 9009472 200 µM -2.11867677568716 0.0228771078056823 no 3259 0.0170588961818202 1054 5742383
SGTC_794 k038-0031 316 µM -2.1232533672854 0.022644732524778 no 3260 0.0168663130507381 1062 6624242
SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.13625076996929 0.0219956161056075 no 3261 0.0163294896161776 1067 6708630 An antioxidant.
SGTC_3264 9137442 49.47 µM -2.1382831384202 0.0218955495875872 no 3262 0.0162468851143461 1056 17015726
SGTC_3137 9097352 49.47 µM -2.14121470118815 0.0217518873401911 no 3263 0.016128364020007 1055 44120435
SGTC_3106 9121286 49.47 µM -2.14506622347919 0.0215643531267573 no 3264 0.0159737762668975 1059 15943471
SGTC_1799 st045822 46.1415 µM -2.14919472262101 0.0213648518123943 no 3265 0.0158094837280045 1048 3674992
SGTC_1123 mangostin 811.285 nM -2.16341727875024 0.0206894831914451 no 3266 0.01525454989559 1050 5281650 An antioxidant.
SGTC_2102 5377816 72.7585 µM -2.17037862409619 0.0203655646829909 no 3267 0.0149890873939153 1069 1379702
SGTC_1927 st060202 13.8 µM -2.17324010288083 0.0202336691903572 no 3268 0.0148811254701836 1057 688887
SGTC_398 bronopol 33.3 µM -2.17767620918701 0.0200306256592987 no 3269 0.0147150756698015 1073 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_264 promethazine 12.5 mM -2.18220955118475 0.0198249198517827 no 3270 0.0145470353593747 1066 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.18443889003746 0.0197244203440507 no 3271 0.0144650065710659 1078 5393153
SGTC_3271 9137798 49.47 µM -2.18703595200085 0.019607889435969 no 3272 0.0143699497753568 1066 6498326
SGTC_3155 9099265 49.47 µM -2.18772314856789 0.0195771527228519 no 3273 0.0143448874116265 1068 25236499
SGTC_1413 3910-0535 34.4 µM -2.20790169624801 0.0186926828121303 no 3274 0.0136255632908186 1077 2876951
SGTC_2851 9015922 71.43 µM -2.21826107541258 0.0182519759406706 no 3275 0.0132685182733762 1071 2996893
SGTC_1395 3486-0190 4.35 µM -2.22863571956606 0.0178195237142804 no 3276 0.0129190761984309 1079 6748079
SGTC_3327 9140648 26.9345 µM -2.23712919832964 0.0174720210857249 no 3277 0.012638948559359 1058 8029710
SGTC_1369 1866-0067 208 µM -2.23943546824978 0.0173786671332303 no 3278 0.0125637978767895 1063 3531355
SGTC_571 k831-0106 44.2 µM -2.24789515378316 0.0170398716371055 no 3279 0.0122914381376315 1070 4783639
SGTC_1501 4491-0275 38.4 µM -2.25348212577308 0.016819232122364 no 3280 0.0121143832447318 1081 5104718
SGTC_1410 3909-8106 77.9 µM -2.25890771748674 0.0166073090350478 no 3281 0.0119445629198334 1077 1039210
SGTC_1032 k061-1018 98.7 µM -2.26419123880442 0.0164031355068023 no 3282 0.0117811776055902 1085 4005393
SGTC_111 0083-0039 52.457 µM -2.28690428098371 0.0155497256320814 no 3283 0.0111007053492966 1079 759313
SGTC_459 nigericin 15.3 µM -2.29460045680427 0.0152693302098942 no 3284 0.0108780160374687 1079 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2455 5377712 9.75 µM -2.29757505861624 0.0151621258046233 no 3285 0.0107929932753273 1073 2243908
SGTC_2457 5731572 11.68 µM -2.30692547018194 0.0148293388062765 no 3286 0.0105294876722995 1078 2865357
SGTC_1084 voriconazole 435 nM -2.31237784484928 0.0146381996835508 no 3287 0.0103784350968731 1081 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_378 3970-0959 8.33 µM -2.32129602932923 0.0143301315880898 no 3288 0.0101354361970907 1085 6615653
SGTC_69 0096-0274 206.684 µM -2.32379577948915 0.0142447889684207 no 3289 0.0100682210287321 1073 6741392
SGTC_2275 7947463 200 µM -2.32795184365196 0.0141038679960716 no 3290 0.00995733045004961 1052 1225414
SGTC_1177 0983-0204 23.6 µM -2.34077230392427 0.0136767041688681 no 3291 0.00962194971004994 1085 766818
SGTC_2970 9090938 41.86 µM -2.35566851117272 0.0131944412793431 no 3292 0.00924470443472578 1068 17217104
SGTC_1553 gossypol 38.6 µM -2.37192840765912 0.0126848700347422 no 3293 0.0088477595504434 1077 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_307 1501-1223 22.3 µM -2.39383135433384 0.0120254277936566 no 3294 0.00833670661918463 1086 2830329
SGTC_3272 9137413 49.47 µM -2.39481011609153 0.01199666677743 no 3295 0.00831448725821905 1069 17614870
SGTC_356 1634-0012 32.5 µM -2.39549441718354 0.0119765939678723 no 3296 0.00829898350120158 1077 735457
SGTC_1379 2144-0755 36.5 µM -2.39648756739847 0.0119475134098456 no 3297 0.00827652751621447 1070 5392327
SGTC_2103 5378138 10 µM -2.42699454072973 0.0110835811194035 no 3298 0.007612242473008 1082 244142
SGTC_702 1488-0190 94 µM -2.45028543394752 0.0104610807692263 no 3299 0.00713715046035896 1087 949357
SGTC_2976 9009005 19.48 µM -2.45207196667545 0.0104146151852127 no 3300 0.00710181257531037 1069 2993148
SGTC_1432 4049-0298 68.4 µM -2.45879516723898 0.0102413613587048 no 3301 0.00697020645401311 1085 741646
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -2.46912490119256 0.00998006679322072 no 3302 0.00677219669954296 1074 6708760
SGTC_713 1488-1073 324 µM -2.4702943800613 0.00995085429121394 no 3303 0.00675009526716021 1086 3312542
SGTC_1490 4089-0339 670 nM -2.48280241614584 0.00964305420550927 no 3304 0.00651766841793029 1079 742542
SGTC_1322 1348-1070 12 µM -2.4919515205303 0.00942321160720551 no 3305 0.00635216882445465 1084 6758089
SGTC_3108 9121785 49.47 µM -2.53175942595018 0.00851691465535163 no 3306 0.00567459140230814 1039 17140271
SGTC_1885 st057546 99.9 µM -2.53666359458733 0.00841073301258031 no 3307 0.0055957219663527 1081 702008
SGTC_1914 st062367 72.6 µM -2.54338457754213 0.00826710325695356 no 3308 0.00548921608105089 1078 978205
SGTC_1085 doxorubicin 7.67 µM -2.57688843824918 0.00758278752563333 no 3309 0.00498470605883449 1080 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2915 7971052 15.16 µM -2.61978504265787 0.00677974627866684 no 3310 0.00439926038577869 1082 5741558
SGTC_1892 st058411 7.36 µM -2.6208221424882 0.00676129881530161 no 3311 0.00438590059185591 1088 3934738
SGTC_895 0964-0006 13.7 µM -2.63411634922965 0.00652872572728109 no 3312 0.00421782879387286 1083 6738897
SGTC_1246 0422-0085 105 µM -2.65626806784397 0.00615688623593267 no 3313 0.00395053897679726 1079 264295
SGTC_1605 st000082 49.1 µM -2.68405730317883 0.00571702169636046 no 3314 0.00363673192582428 1075 1114022
SGTC_1628 st004252 77.7 µM -2.68734654234121 0.00566684936464483 no 3315 0.00360110939172233 1084 692968
SGTC_648 0375-0473 33.3 µM -2.73110030722859 0.00503568297964272 no 3316 0.00315616281026552 1085 1713139
SGTC_2099 5377090 177.372 µM -2.74077892969068 0.0049048248962984 no 3317 0.00306468660886112 1079 2243829
SGTC_1377 2944-0135 198 µM -2.74907288168486 0.00479510812192461 no 3318 0.00298820479881991 1075 1894137
SGTC_3269 9137823 49.47 µM -2.77946868833772 0.00441148397181976 no 3319 0.00272239512171565 1086 17682936
SGTC_2182 6325192 200 µM -2.78438052405001 0.00435213392813778 no 3320 0.00268150375299317 1080 736248
SGTC_171 k064-0041 9.68 µM -2.80883238622499 0.00406716925832329 no 3321 0.00248607630428165 1078 53325
SGTC_716 1683-5115 658 µM -2.81048500899333 0.00404852596767575 no 3322 0.00247334466580357 1087 723597
SGTC_2954 9074818 52.69 µM -2.82321898291879 0.00390742044056579 no 3323 0.00237720427294469 1084 16648742
SGTC_2766 oltipraz 83.91 µM -2.86799383292246 0.00344559044723733 no 3324 0.00206541792610357 1037 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1331 1472-0049 76.2 µM -2.87456409056394 0.00338211440927986 no 3325 0.0020229282392477 1085 24051409
SGTC_1603 st002045 67.8 µM -2.88217822336909 0.00330986953671783 no 3326 0.00197468140641027 1091 5887985
SGTC_71 0417-1750 47.813 µM -2.89463360234999 0.00319467698886525 no 3327 0.00189800665812989 1075 6811472
SGTC_2344 7990960 76.95 µM -2.89970271401116 0.00314883783454306 no 3328 0.00186758366787772 1066 140813
SGTC_1602 st001878 87.6 µM -2.9893772147903 0.00243003127822759 no 3329 0.00139773388958509 1082 595405 YLR310C CDC25
SGTC_306 1672-3436 11.6 µM -2.99030664526268 0.00242343042385888 no 3330 0.0013934875540985 1093 6797378
SGTC_2982 9019404 25.97 µM -3.01209096898057 0.0022732905322324 no 3331 0.00129727416379861 1083 22333232
SGTC_52 0329-0193 875 nM -3.09826582745771 0.00175844451927095 no 3332 0.000973283693548235 1090 3739292
SGTC_309 k408-0051 1.48 µM -3.17833775234608 0.00137763257416461 no 3333 0.0007406104639471 1080 3640463
SGTC_2960 9079389 5.97 µM -3.21371480921472 0.00123473868092073 no 3334 0.000655148732596123 1087 16457355
SGTC_2953 9074162 66.49 µM -3.22120679044709 0.00120627425423778 no 3335 0.000638260030252942 1087 16451992
SGTC_1520 flindersine 88 µM -3.23669635077746 0.00114931994548791 no 3336 0.0006046100280193 1084 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_874 0599-0792 117 µM -3.42644438171581 0.000625399904961101 yes 3337 0.000305769493905769 1091 765305
SGTC_1627 st003713 25.6 µM -3.51436638580068 0.000467000961493221 yes 3338 0.000220402183143002 1092 16195070 YER133W GLC7
SGTC_3186 9110464 49.47 µM -3.57133249297018 0.000385168045705018 yes 3339 0.000177584834518468 1094 17018021
SGTC_351 caspofungin 25 nM -3.6350673334886 0.000309495255754359 yes 3340 0.000138954020688732 1090 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_547 1120-0019 610 nM -3.75692810586742 0.000201806267150455 yes 3341 8.60059438356255e-05 1077 3676939
SGTC_593 1203-0218 61.7 µM -3.80566161304153 0.000169495550041563 yes 3342 7.07128155159967e-05 1094 3666956
SGTC_2341 7987486 176.74 µM -4.16917580650437 4.33201312317303e-05 yes 3343 1.52851558965218e-05 1094 1258686
SGTC_372 0155-0182 15.9 µM -4.18747978345085 4.03258383913739e-05 yes 3344 1.41034568623026e-05 1013 771486
SGTC_1353 1498-1206 8.11 µM -4.47712525597037 1.25033152175351e-05 yes 3345 3.7827433107506e-06 1067 6756808
SGTC_1036 k216-0215 33.5 µM -4.47874125002948 1.24194260768916e-05 yes 3346 3.7542240044374e-06 1078 622330
SGTC_383 2324-0395 7.37 µM -4.48248637045321 1.22270637025724e-05 yes 3347 3.68891781039184e-06 1091 3146421
SGTC_164 4100-3994 89.624 µM -4.57352646714869 8.33561195325459e-06 yes 3348 2.39791532350364e-06 1094 4615967
SGTC_2054 5233173 129 µM -4.6356055515819 6.39343157030492e-06 yes 3349 1.77947030368678e-06 1065 6889
SGTC_778 3456-2434 196 µM -4.65506748220372 5.87929731469689e-06 yes 3350 1.61937306371401e-06 1051 5539063
SGTC_2925 9010536 32.5 µM -4.86236259532473 2.35973642161388e-06 yes 3351 5.79964470644989e-07 1075 2994177
SGTC_73 0327-0325 16.231 µM -5.01402973648582 1.18234063079531e-06 yes 3352 2.66508717773308e-07 1085 53298
SGTC_2739 tacrine 100.86 µM -5.09254625310744 8.20409380570097e-07 yes 3353 1.76643245098317e-07 1076 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_116 0155-0182 31.788 µM -5.67427186389631 4.64397220272822e-08 yes 3354 6.96398959663673e-09 1067 771486
SGTC_141 0443-0274 32.331 µM -6.71845254237912 1.29329846562358e-10 yes 3355 9.1832269657574e-12 1072 1627241
SGTC_2965 9082772 38.63 µM -11.8128057650357 5.56237481904823e-29 yes 3356 1.67592965760528e-32 1094 16459634