SGTCid condition conc unit VPS60|YDR486C.score VPS60|YDR486C.strain.pval VPS60|YDR486C.strain.significant VPS60|YDR486C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2322 7413319 38.22 µM 10.2206594483659 5.06007361859296e-23 yes 1 8.01234915426228e-25 18 1840400
SGTC_568 1193-0097 7.48 µM 6.7788622897965 3.8753647202911e-11 yes 2 6.05629554082132e-12 50 3646150
SGTC_1060 3448-7350 82 µM 6.38665495321396 4.43011163479778e-10 yes 3 8.4776809912897e-11 11 570178
SGTC_1495 4469-0029 237 µM 6.29012776636403 7.89935084880032e-10 yes 4 1.58602393464868e-10 45 793680
SGTC_2249 haloperidol 116.36 µM 6.28981673117894 7.913978541932e-10 yes 5 1.58920491001641e-10 39 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_525 k781-2675 26.7 µM 5.93452632040679 6.18724813109588e-09 yes 6 1.47347527766758e-09 26 3651118 YDL195W SEC31
SGTC_951 1171-0579 82.7 µM 5.6627804178613 2.7628397188246e-08 yes 7 7.44698504193453e-09 37 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_300 r073-0011 5.04 µM 4.8051740858939 2.01443020939549e-06 yes 8 7.73084562601439e-07 7 2735780
SGTC_2038 4100038 30.985 µM 4.6801527681519 3.56415026377938e-06 yes 9 1.43330616464545e-06 29 3596803
SGTC_2804 7954240 19.48 µM 4.56309754435637 6.00504189403787e-06 yes 10 2.5202190802234e-06 21 828705
SGTC_255 tunicamycin 200.472 nM 4.51474869903037 7.42263151831439e-06 yes 11 3.1695945477608e-06 53 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 4.35620534385151 1.46582652261482e-05 yes 12 6.61683172605555e-06 45 442882
SGTC_2338 7999974 200 µM 4.34649954080789 1.52707775998098e-05 yes 13 6.91636704508506e-06 11 315925
SGTC_1658 st012944 20 µM 4.31521421461065 1.74149564014697e-05 yes 14 7.97241043558017e-06 67 24207260
SGTC_37 0566-0070 1.56 µM 4.28748643704139 1.95515779729833e-05 yes 15 9.03531436215202e-06 19 1626686
SGTC_2021 4019055 173 µM 4.26557021257784 2.14140611590333e-05 yes 16 9.96961469914595e-06 104 44827708 YER133W GLC7
SGTC_2334 9017922 200 µM 4.26367613204322 2.15826931450998e-05 yes 17 1.00545426030966e-05 17 3163164
SGTC_2050 5263056 171 µM 4.25704201752171 2.21833228174414e-05 yes 18 1.03574717548936e-05 35 763468 YGL055W OLE1
SGTC_351 caspofungin 25 nM 4.0945418267406 4.29314319204009e-05 yes 19 2.11502024042202e-05 89 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1183 1254-0324 198 µM 4.01852086831798 5.8004718662038e-05 yes 20 2.92823115608246e-05 20 5799357
SGTC_1177 0983-0204 23.6 µM 4.01826345815813 5.80633513926073e-05 yes 21 2.93143120043943e-05 15 766818
SGTC_235 0330-0087 5 mM 3.94943670522869 7.59132492737039e-05 yes 22 3.91676604580858e-05 21 46494818 YHR062C RPP1
SGTC_2060 5238662 140 µM 3.93556167357822 8.00880916351429e-05 yes 23 4.15011724205539e-05 31 790130
SGTC_2013 4024628 200 µM 3.93459187183826 8.03878296630347e-05 yes 24 4.16690935444732e-05 43 5230760
SGTC_236 1509-0011 5.31 µM 3.91131978257463 8.79051695899864e-05 yes 25 4.58965689343526e-05 385 3107280
SGTC_1844 rapamycin 4 nM 3.88303446510731 9.79320630493938e-05 yes 26 5.15804696045637e-05 165 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1569 carminic acid 40.6 µM 3.75142561449109 0.000160399256513943 yes 27 8.79159611034986e-05 22 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3197 9113331 49.47 µM 3.69486688382495 0.000197365760228872 yes 28 0.000110001008051459 38 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_308 4092-1169 104 µM 3.66710235103597 0.000218295060249432 yes 29 0.000122657310603407 60 2268590 YDL196W YDL196W
SGTC_2619 obliquin 87.91 µM 3.61774771359348 0.00026069623069347 yes 30 0.000148588929158896 163 6708593 A bioactive alkalod. YER133W GLC7
SGTC_137 0438-0332 85.389 µM 3.61657306522647 0.00026179317498797 yes 31 0.000149264539788789 145 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_212 3807-4682 38.772 µM 3.60102876012293 0.000276720187208246 yes 32 0.000158480254214352 90 3125501 YBL034C STU1
SGTC_117 lucigenin 22.078 µM 3.56636840188647 0.000312904140256129 yes 33 0.000180981221637009 105 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2753 fluvastatin 17.09 µM 3.41170094270754 0.000534633762023538 yes 34 0.000322794493005991 57 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2566 crystal violet carbinol 226 nM 3.29135918829994 0.000799567919521203 yes 35 0.000498522590367085 67 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_70 0141-0289 43.283 µM 3.20051846752228 0.00107451736200749 no 36 0.000685902890482965 249 352408
SGTC_2704 st078022 71.1 µM 3.16598325268683 0.00120006136004689 no 37 0.000772798460176425 36 54697681
SGTC_3346 9158254 43.5805 µM 3.14047503380759 0.00130126010852831 no 38 0.000843370418285261 55 17639500
SGTC_339 3091-4833 71.4 µM 3.07769157120533 0.00158443106131335 no 39 0.00104305352197129 49 3240077
SGTC_2046 4110841 106 µM 3.07117052392687 0.0016168539269016 no 40 0.00106610669865274 57 44119630 YMR134W ERG29
SGTC_1055 3448-0672 86 µM 3.06270373035595 0.00165985297822931 no 41 0.0010967355389085 79 748378
SGTC_2045 5106652 78.05 µM 3.05670982470525 0.00169092019925299 no 42 0.00111890398008529 45 673349
SGTC_2015 5119600 184 µM 3.04252031217237 0.00176658748180394 no 43 0.00117302991617332 69 2828786
SGTC_1910 st062352 60.4 µM 2.98283155543098 0.00211978586067104 no 44 0.00142797563645308 81 2245730
SGTC_1913 st060213 96.1 µM 2.97403269941035 0.00217695272094944 no 45 0.00146956876118636 91 688959
SGTC_350 k064-0020 19.8 µM 2.9567322664316 0.00229344824503246 no 46 0.00155458980746931 70 2790705
SGTC_1938 st074717 56.4 µM 2.94561342000838 0.00237126982082825 no 47 0.00161157477053666 41 17250979
SGTC_108 0509-0257 621.132 µM 2.94144427100968 0.00240106075322261 no 48 0.00163342809812633 96 536624
SGTC_881 0833-0569 170 µM 2.93110955460039 0.00247637388172858 no 49 0.00168876823029303 81 5418700
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.91978325080117 0.00256136145713367 no 50 0.00175137457389949 51 756377
SGTC_2693 st077581 40.7 µM 2.89406577025956 0.00276420135248231 no 51 0.00190144248381937 102 25238761
SGTC_1401 3807-4679 7.6 µM 2.85718112737882 0.00308045274123449 no 52 0.00213710927859969 54 3291456
SGTC_1811 st050069 61.5 µM 2.85659747998562 0.00308570877533215 no 53 0.00214104246679808 30 3877702
SGTC_847 0342-0274 5.54 µM 2.85427738951449 0.00310668228732325 no 54 0.00215674250364687 70 18097
SGTC_2688 kanamycin b 96.69 µM 2.83422064761846 0.00329341411495365 no 55 0.00229688008807606 574 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_603 3794-0023 45.9 µM 2.82583704852493 0.00337441394871914 no 56 0.00235786234427084 51 3802260
SGTC_2187 6125751 200 µM 2.82198818237947 0.00341219672770987 no 57 0.00238634679694152 78 874498
SGTC_408 cantharidin 100 µM 2.8042759693085 0.00359101598274085 no 58 0.00252148601401461 83 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3339 9145883 14.936 µM 2.79807214069539 0.00365561025023691 no 59 0.00257043145858393 61 2030670
SGTC_703 3875-0075 71.8 µM 2.7662134424108 0.00400403114052487 no 60 0.00283557012449922 34 2850814
SGTC_2571 chrysanthemic acid 100 µM 2.76497476478746 0.00401815926600713 no 61 0.00284635997771734 80 2743 An insecticide.
SGTC_2616 abietic acid 100 µM 2.76302577687711 0.00404047943549685 no 62 0.00286341217836407 84 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_390 dec-rvkr-cmk 16.7 µM 2.74896128121771 0.00420486638311835 no 63 0.0029892223910204 108 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2118 5526350 200 µM 2.72825271690373 0.00445780390285271 no 64 0.00318354040946964 83 743594
SGTC_1184 1269-1718 139 µM 2.71752276685181 0.00459413409617386 no 65 0.00328863150906036 76 5403821
SGTC_922 1866-0035 480 µM 2.70364966647688 0.00477591020215461 no 66 0.00342912772656524 156 3156169
SGTC_1054 3429-0080 167 µM 2.69679596145781 0.0048680578173867 no 67 0.00350050766254694 91 1162877
SGTC_1828 st055811 49 µM 2.69428815824485 0.00490216902091186 no 68 0.00352695755376301 48 5877589
SGTC_1283 0922-0125 16.4 µM 2.68242799066334 0.00506639384343874 no 69 0.00365449425784872 80 3360884
SGTC_1596 piperlongumine 63 µM 2.67895946085431 0.00511533871892185 no 70 0.00369256671986614 76 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1311 1190-0148 100 µM 2.67702177577948 0.0051428645078699 no 71 0.00371399035665984 108 1961333
SGTC_346 4513-0042 7.16 µM 2.64426892864332 0.00562850442092117 no 72 0.00409337913655048 107 2827372
SGTC_2863 9028737 58.44 µM 2.62393353591283 0.00595012994043098 no 73 0.00434603725511131 48 6460917
SGTC_865 0488-0499 301 µM 2.61911732526699 0.00602864988105701 no 74 0.00440788106898306 80 9634651
SGTC_3308 9128332 17.569 µM 2.61383615395854 0.00611580467162087 no 75 0.00447659803912472 186 17332805 YDL196W YDL196W
SGTC_1929 genistein trimethyl ether 50.5 µM 2.61217632420312 0.00614342635353328 no 76 0.00449839197264456 85 136420
SGTC_1453 4237-0541 195 µM 2.60995743701275 0.00618052406651143 no 77 0.00452767443013759 106 739892
SGTC_2384 9036245 200 µM 2.60649784188617 0.00623876119192943 no 78 0.00457367001896554 108 6462766
SGTC_3150 9097574 49.47 µM 2.60247804008848 0.00630703848281168 no 79 0.00462763711453821 64 17217476
SGTC_41 0478-0632 82.643 µM 2.59922498646503 0.00636277579496562 no 80 0.00467172562091464 125 3750424
SGTC_734 2023-0417 80 µM 2.59031642883583 0.00651765149915907 no 81 0.00479438736712298 109 3935732
SGTC_1718 roemerine 11.9335 µM 2.58754444805567 0.00656651800779707 no 82 0.00483313618743221 162 235224 An aporphine alkaloid with mutagenic activity.
SGTC_190 3970-0790 3.722 µM 2.58110285632574 0.00668132831433653 no 83 0.0049242617047004 68 2832352
SGTC_2383 9036125 200 µM 2.57903597433185 0.0067185410633034 no 84 0.00495382341187485 49 79580
SGTC_2537 larixol 68.93 µM 2.57029906141987 0.00687787417794996 no 85 0.00508053773753801 124 6708759
SGTC_3215 9129942 49.47 µM 2.5670617280811 0.00693775462565119 no 86 0.00512821762452444 72 17682944
SGTC_1230 0170-0365 3.77 µM 2.56151659759773 0.00704139201274983 no 87 0.00521081307384386 214 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3190 9110366 49.47 µM 2.54478090368197 0.00736250986393013 no 88 0.00546731615420637 75 17123768
SGTC_733 4069-0007 56.1 µM 2.53401383131101 0.00757586447417817 no 89 0.00563821403529359 206 5717425 YNL287W SEC21
SGTC_1741 st038134 10.228 µM 2.51367094990824 0.00799387082729262 no 90 0.005974092764365 142 1272587
SGTC_311 1315-0136 58 µM 2.50654861540516 0.00814494162786896 no 91 0.00609581454334731 89 6759207
SGTC_2035 5154463 94.595 µM 2.50246762586348 0.00823262866456672 no 92 0.00616654522406459 128 2769623
SGTC_1728 st035614 33.7865 µM 2.49864394633874 0.00831553830764556 no 93 0.00623347497068659 185 15945546
SGTC_3285 9112818 20.8695 µM 2.49583161030415 0.00837698586971298 no 94 0.00628311192870731 121 17017947 YPR165W RHO1
SGTC_598 3937-0236 20.2 µM 2.48567018779084 0.00860234053445767 no 95 0.00646538711483536 150 1379313
SGTC_377 3970-0964 33.1 µM 2.47328458963048 0.00888419953433139 no 96 0.00669387425911308 193 16481235
SGTC_2303 7774051 200 µM 2.47227876820623 0.00890744035119984 no 97 0.00671273904287226 112 2953184
SGTC_3230 9131665 49.47 µM 2.46885743331331 0.00898689402122147 no 98 0.0067772604240016 23 15943720
SGTC_3249 9135183 49.47 µM 2.46587942562102 0.00905655696508155 no 99 0.00683386668853025 111 4902779
SGTC_214 4373-3496 70 µM 2.46163340804277 0.00915669945142556 no 100 0.00691529754040699 213 3779166
SGTC_1315 1237-0019 3.69 µM 2.45882111821317 0.00922355986368507 no 101 0.00696970266520208 100 825140
SGTC_2898 9056270 58.44 µM 2.45279226633528 0.00936833338693052 no 102 0.00708760866569416 64 19154699
SGTC_1971 st069429 63.5 µM 2.45238448933237 0.00937819690237469 no 103 0.00709564672030021 99 1246522 YGL099W LSG1
SGTC_297 0986-0032 24 µM 2.45025685193791 0.00942980875425339 no 104 0.00713771707526462 77 2847425
SGTC_78 0336-0123 156.75 µM 2.43901235162494 0.00970672190941706 no 105 0.00736373243075796 101 6765896
SGTC_405 ebelactone b 50 µM 2.41830397145239 0.0102353283979789 no 106 0.00779652237464774 131 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1191 1487-1166 10.6 µM 2.41400336042888 0.0103482024462609 no 107 0.00788915841923597 147 3955771
SGTC_748 act1.228 77.9 µM 2.40307763883452 0.0106398526888376 no 108 0.00812886767257686 207 4421505 YNR035C ARC35
SGTC_2802 7925815 54.55 µM 2.39708991489128 0.0108027054428658 no 109 0.00826293393226442 163 1262923
SGTC_1789 tunicamycin 25 nM 2.38855955339299 0.0110384581575379 no 110 0.00845728335938498 161 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.37739575401631 0.0113537433066975 no 111 0.00871768524121228 225 6708739 YPR165W RHO1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.37371658765036 0.0114593498736552 no 112 0.00880503078326014 148 688761
SGTC_2786 7743617 45.45 µM 2.36367493370328 0.0117519384862249 no 113 0.00904734084439972 132 583674
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.31714379336063 0.0131939038386872 no 114 0.0102479500520848 108 61125 An anti-inflammatory.
SGTC_2048 5246248 200 µM 2.3108968987376 0.0133986793431757 no 115 0.0104192752042117 90 677046
SGTC_678 1218-2179 85.9 µM 2.30853919199264 0.0134766761389629 no 116 0.0104845828067063 67 6820081 YOR116C RPO31
SGTC_414 piperonyl butoxide 100 µM 2.30404228682796 0.0136265283622072 no 117 0.0106101349700694 112 5794 A potent inhibitor of cytochrome P450.
SGTC_64 000l-0018 272.079 µM 2.28486026828019 0.0142819958837912 no 118 0.0111605111992771 325 6811119
SGTC_43 0570-0105 72.5 µM 2.2833996413387 0.0143330013075662 no 119 0.0112034191890747 320 1114046 YDL195W SEC31
SGTC_1846 st056244 14.8 µM 2.26964060443871 0.0148212175105273 no 120 0.0116146989388418 184 5393182
SGTC_306 1672-3436 11.6 µM 2.26411148117452 0.0150214001585782 no 121 0.0117836295054749 138 6797378
SGTC_1216 1165-0504 9.65 µM 2.26346969914612 0.0150447858003711 no 122 0.0118033752173189 144 6304004
SGTC_1419 3993-2473 62.6 µM 2.2575719996839 0.0152611585871333 no 123 0.0119861779851387 149 704026
SGTC_248 streptozotocin 5.23457 mM 2.23697477611329 0.01603791593842 no 124 0.0126439943340061 165 5300 DNA alkylating agent.
SGTC_3345 9148410 3.559 µM 2.20766690982761 0.0172014302126616 no 125 0.013633750572722 108 4903596
SGTC_159 3970-0959 50 µM 2.19767634268939 0.0176141987323131 no 126 0.0139860892905459 353 6615653
SGTC_751 0833-0568 350 µM 2.19581807929756 0.0176918996519237 no 127 0.0140524835456353 164 6954252
SGTC_1565 sinapyl alcohol 95.1 µM 2.19203715056916 0.0178508976665886 no 128 0.0141884121122363 186 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1358 1509-0022 2.48 µM 2.18528836224782 0.0181377320813372 no 129 0.0144338550748881 156 3258434
SGTC_1308 1187-1617 41.4 µM 2.18059345644143 0.018339582225433 no 130 0.0146067497763158 211 2882570
SGTC_3328 9140624 29.0385 µM 2.17407665338313 0.0186229313948834 no 131 0.014849689490242 176 4904392
SGTC_2240 6690706 185.951 µM 2.17031709541387 0.018788085002212 no 132 0.0149914162099446 140 805876
SGTC_1898 st060199 18.6 µM 2.16858122271549 0.0188647597213173 no 133 0.0150572460128434 142 688866
SGTC_1590 st077108 57.8 µM 2.16589529501813 0.0189839236040633 no 134 0.0151595944662433 121 5489485
SGTC_2608 thymoquinone 42.66 µM 2.14014621170335 0.0201591474752539 no 135 0.0161714762390984 160 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1788 fluconazole 20 µM 2.12881239449989 0.0206956720297017 no 136 0.0166348925270434 219 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2963 9082507 9 µM 2.12593861517522 0.0208336181524846 no 137 0.0167541855317326 176 16459611
SGTC_1186 1319-0216 26 µM 2.11569228868158 0.0213318109283287 no 138 0.0171854934259592 195 4565136
SGTC_637 1181-0519 7.26 µM 2.10802115361957 0.0217113553873532 no 139 0.0175145798540341 308 6252091 YGR060W ERG25
SGTC_488 nitrendipine 139 µM 2.10590625793571 0.0218169917715821 no 140 0.0176062479908848 211 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2564 betulinic acid 100 µM 2.10219657184844 0.0220033345004953 no 141 0.0177680299978524 243 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1201 1889-3372 45.9 µM 2.09732037869417 0.0222503148160192 no 142 0.0179826120343917 141 5392199
SGTC_3264 9137442 49.47 µM 2.07507034408759 0.0234071695726486 no 143 0.0189900078827637 149 17015726
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.06147814643034 0.0241384719453056 no 144 0.019628723126203 272 688788
SGTC_227 fluconazole 33.516 µM 2.06128331198649 0.0241490926053982 no 145 0.0196380096696263 278 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1408 3909-7976 48.8 µM 2.06038879846588 0.0241979040084623 no 146 0.0196806934488288 224 24152374
SGTC_3343 9148379 18.9835 µM 2.0532849381066 0.0245884940066243 no 147 0.0200224753904741 171 1955036
SGTC_2041 5107442 45.335 µM 2.04849248338202 0.0248549741114623 no 148 0.020255883930963 243 793005
SGTC_591 4299-0174 154 µM 2.03090419150901 0.0258537980545191 no 149 0.0211323572579285 163 5509088
SGTC_3015 9080845 49.47 µM 2.02869264444547 0.0259817349451063 no 150 0.0212448027818073 169 5296973
SGTC_1032 k061-1018 98.7 µM 2.00971463094586 0.0271015252209331 no 151 0.0222307002710658 260 4005393
SGTC_2226 7298446 200 µM 2.00792900674331 0.0272089275927024 no 152 0.022325418137557 140 3283010
SGTC_2297 7971671 152.32 µM 2.0000207214394 0.0276888757579429 no 153 0.0227490132008208 214 909016
SGTC_3271 9137798 49.47 µM 1.99280731130825 0.0281327852879276 no 154 0.023141275430088 148 6498326
SGTC_1499 4480-0877 67.3 µM 1.99239342275686 0.0281584344975531 no 155 0.0231639542198211 150 2861909
SGTC_1861 st057647 17.4 µM 1.98757070271073 0.0284587423917593 no 156 0.023429594590257 218 688668
SGTC_1624 st003710 6.25 µM 1.98639278840596 0.0285324939311739 no 157 0.0234948633835033 276 24207033
SGTC_1687 st020778 55.3625 µM 1.97369294266927 0.0293378013196205 no 158 0.0242083340646475 421 4259299
SGTC_2697 mebhydrolin 72.4 µM 1.96440548183159 0.0299386009725296 no 159 0.0247415438176252 302 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2122 5258151 111.688 µM 1.96374196082126 0.029981911440936 no 160 0.0247800119145699 242 2173356
SGTC_875 0709-0210 25.7 µM 1.95892618738789 0.0302978142480751 no 161 0.0250607158445565 261 6251364
SGTC_2582 agaric acid 100 µM 1.95398961606687 0.0306244991612238 no 162 0.0253512226149726 679 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_661 1304-0007 33.6 µM 1.94390487354285 0.0313009418676667 no 163 0.0259534617273526 210 3117130
SGTC_489 paxilline 115 µM 1.94307675828496 0.0313570331533263 no 164 0.0260034423616038 213 105008 A toxic potassium channel blocker.
SGTC_2440 5628896 157.78 µM 1.94072680099457 0.0315166571106572 no 165 0.0261457118800936 213 5522048
SGTC_696 1560-0013 611 µM 1.94039585157646 0.0315391911517847 no 166 0.0261658001869467 236 1650269
SGTC_342 k048-0088 23.3 µM 1.94034711792275 0.0315425105060162 no 167 0.0261687593620569 223 6820570
SGTC_1089 terbinafine 2.25 µM 1.93774686755068 0.0317200383441461 no 168 0.0263270564610354 221 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1120 ficusin 1.78878 µM 1.93553937527775 0.0318713984613654 no 169 0.0264620708243255 240 6199 A DNA cross-linker.
SGTC_2386 9075165 157.42 µM 1.93198669005867 0.0321162461355908 no 170 0.0266805743544297 184 16452277
SGTC_800 3448-7362 155 µM 1.92659921689849 0.0324905069809086 no 171 0.0270147981653891 527 15991913
SGTC_1356 1502-0781 85.8 µM 1.92446140751242 0.0326400115713856 no 172 0.0271483868315199 236 567702
SGTC_762 1165-0429 115 µM 1.91239724809065 0.0334943708954429 no 173 0.0279126303525673 245 5967793
SGTC_701 4424-0219 185 µM 1.90873699057725 0.0337571937799571 no 174 0.0281480143872107 245 2911779
SGTC_1870 st057514 26.5 µM 1.90614048051953 0.0339446617572163 no 175 0.0283159909529183 251 5393161
SGTC_1707 st032323 6.317 µM 1.90145842022889 0.034284870273697 no 176 0.0286209968818182 310 3132057 YMR211W DML1
SGTC_2995 9067767 71.4286 µM 1.89631104199751 0.0346621187360941 no 177 0.028959463515102 220 11673567
SGTC_1940 st075990 51.1 µM 1.89550021494974 0.0347218534434672 no 178 0.029013081643926 286 1084979
SGTC_924 2046-0044 21.3 µM 1.89261950262364 0.0349347634022562 no 179 0.0292042441464977 233 3623589
SGTC_1926 methyl fluorone black 53.6 µM 1.88954588940681 0.0351631108862964 no 180 0.0294093599452038 272 72721 Reacts with homocysteine.
SGTC_1503 4585-0012 61.3 µM 1.88498793018561 0.035503987822375 no 181 0.0297157336924994 229 2922052
SGTC_2316 5844804 197.44 µM 1.87898013790672 0.03595742797194 no 182 0.0301236026564564 352 776813
SGTC_849 0386-0493 241 µM 1.87400032278963 0.0363368670941322 no 183 0.0304651903119152 229 726119
SGTC_721 1187-1332 279 µM 1.87268434459243 0.0364376842482065 no 184 0.0305559932318116 165 25730
SGTC_2570 licareol 100 µM 1.86543633561473 0.0369970644429832 no 185 0.0310601341020422 275 443158
SGTC_1084 voriconazole 435 nM 1.86344672188416 0.0371518390228966 no 186 0.0311997208925224 234 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1324 1418-0026 34.4 µM 1.86310733340293 0.0371782932363078 no 187 0.0312235833462845 278 1372513
SGTC_3048 9093155 49.47 µM 1.86234860326897 0.037237489421241 no 188 0.0312769843714412 196 25236002
SGTC_3011 9081274 71.4286 µM 1.8587552281501 0.0375188917173932 no 189 0.0315309206236669 293 6625322
SGTC_1476 4112-3294 3.34 µM 1.85718154888941 0.0376426743544034 no 190 0.0316426645731014 242 704369
SGTC_681 1642-0006 26.6 µM 1.85084712587498 0.0381443042999213 no 191 0.0320957745949046 181 4446530
SGTC_376 3970-0862 59.1 µM 1.84590582886531 0.0385393850355673 no 192 0.0324529400922832 266 3135186
SGTC_2647 atorvastatin 60.16 µM 1.83681887755356 0.039274633545741 no 193 0.0331183190738923 252 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_735 3076-0345 636 µM 1.83095549895171 0.0397550847282497 no 194 0.0335535927666255 325 2888990
SGTC_3018 9082602 49.47 µM 1.82886054314011 0.0399279019028834 no 195 0.0337102512159196 278 17332089
SGTC_2213 7173844 200 µM 1.82553555371148 0.0402034401676183 no 196 0.0339601255090019 258 892728
SGTC_1520 flindersine 88 µM 1.82380058271039 0.0403478274218438 no 197 0.0340911128857096 293 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_411 enrofloxacin 100 µM 1.82102763682937 0.0405794708461754 no 198 0.0343013279549219 247 71188 A bacterial gyrase inhibitor.
SGTC_3170 9103054 49.47 µM 1.82057841381136 0.0406170989728119 no 199 0.0343354833010284 237 16432970
SGTC_2743 auranofin 4.32 µM 1.81610785639027 0.040993110207673 no 200 0.0346769143975341 257 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_604 1000-0114 314 µM 1.81153184396352 0.0413809100398325 no 201 0.0350292821878622 290 1572745
SGTC_1208 2323-2347 50.3 µM 1.8005691827008 0.0423220550802628 no 202 0.03588540506282 250 5412760
SGTC_341 1486-1430 230 µM 1.7955164525583 0.0427616244080531 no 203 0.0362857269148161 295 2054753 YPL210C SRP72
SGTC_1372 2752-0194 270 µM 1.793479827445 0.0429398437750529 no 204 0.036448116683321 269 823334
SGTC_273 hydroxyurea 18.1 mM 1.7868771888174 0.0435217527324527 no 205 0.0369786700586677 347 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2272 7805186 180 µM 1.77991809241202 0.0441419500334994 no 206 0.0375446831528782 252 2956062 YPR165W RHO1
SGTC_1206 3978-0017 132 µM 1.77953414706517 0.0441763737286149 no 207 0.0375761158658817 284 3873677
SGTC_2159 5658611 73.75 µM 1.77909644144456 0.044215643846477 no 208 0.0376119760144533 234 793844
SGTC_2254 7938975 95.19 µM 1.77681239209003 0.0444210211798495 no 209 0.0377995561534091 370 2969277
SGTC_1525 8-methoxypsoralen 92.5 µM 1.77564420662604 0.0445263588946809 no 210 0.0378957894139955 332 4114 Related to psoralen; DNA damaging agent.
SGTC_1729 st035615 45.989 µM 1.77402188361514 0.0446729808259928 no 211 0.0380297653084964 304 17385451
SGTC_1043 0916-0009 19.3 µM 1.77372666159483 0.0446997041056331 no 212 0.0380541870600328 363 3101130
SGTC_275 trichlorophene 5.69 µM 1.76543963435781 0.0454551067842837 no 213 0.0387449535903508 522 62616
SGTC_3183 9108214 49.47 µM 1.76345510893797 0.0456375211426313 no 214 0.0389118810978349 150 4974831
SGTC_510 ag-490 170 µM 1.76076219878892 0.0458859896721024 no 215 0.0391393301749447 240 5328779
SGTC_2514 salinomycin 42.74 µM 1.75801318264643 0.0461407550101405 no 216 0.0393726331576426 373 23682228 A polyether potassium ionophore.
SGTC_574 1315-0397 40 µM 1.74944930909513 0.0469417018493439 no 217 0.0401066918974824 387 6794277
SGTC_1678 st019265 80.2 µM 1.74904683741266 0.046979616120611 no 218 0.0401414617884457 347 5367020
SGTC_1750 st081859 2.357 µM 1.74336438596464 0.0475175486660704 no 219 0.040634992562797 539 5291695
SGTC_3253 9135987 49.47 µM 1.74331395544927 0.0475223446973241 no 220 0.0406393944888771 241 4182430
SGTC_3257 9139206 32.98 µM 1.73984305092745 0.0478533667388745 no 221 0.0409432903723112 208 4910041
SGTC_2978 9011784 42.97 µM 1.73174627969075 0.0486327374002685 no 222 0.0416593733520645 385 2994934
SGTC_3073 9114972 49.47 µM 1.73106455802377 0.048698818364295 no 223 0.0417201253885994 266 41905075
SGTC_1327 1436-0082 2.18 µM 1.72741071210921 0.0490542187938478 no 224 0.0420469640770641 300 15992205
SGTC_1619 st003326 88.7 µM 1.72583858908208 0.0492077713898629 no 225 0.0421882276645882 264 2849032
SGTC_1660 st012960 28.1 µM 1.72550318765769 0.0492405803890356 no 226 0.0422184149120226 344 24207266
SGTC_2482 5981709 142.65 µM 1.72306560990325 0.0494795495768767 no 227 0.0424383304848844 351 877755
SGTC_2003 4023581 200 µM 1.7078654898917 0.0509906533496725 no 228 0.0438306519412161 325 16641307
SGTC_2274 7947094 46.08 µM 1.70536807308757 0.0512424086568601 no 229 0.0440628994712526 339 2971028
SGTC_2090 5301565 104.445 µM 1.70476652913165 0.051303195613682 no 230 0.0441189881425682 362 2056344
SGTC_508 roscovitine 141 µM 1.70390746367707 0.051390104961539 no 231 0.0441991882090946 261 160355 A CDKinase inhibitor.
SGTC_2156 5649887 115 µM 1.70256128708002 0.0515265295213124 no 232 0.044325100006921 358 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_52 0329-0193 875 nM 1.70187387165082 0.0515963047378549 no 233 0.0443895073706576 335 3739292
SGTC_553 k007-0256 45.7 µM 1.69626637833496 0.0521682957468756 no 234 0.0449177223551488 335 6287000
SGTC_191 3914-0123 66.505 µM 1.69175190574735 0.0526324433550665 no 235 0.0453466435527504 197 3144412
SGTC_2345 9052315 157.45 µM 1.6822555148837 0.0536194930225233 no 236 0.0462596516415497 334 6469265
SGTC_891 0929-0073 133 µM 1.68007380527155 0.053848317287085 no 237 0.0464714783645337 300 5603632
SGTC_2088 5278280 127.392 µM 1.67948517877063 0.0539101864730648 no 238 0.0465287625036205 374 791502
SGTC_746 1095-0025 46.6 µM 1.67567110929632 0.0543124394767127 no 239 0.0469013158925018 342 6749286
SGTC_2750 bromebric acid 70.15 µM 1.67528294585879 0.0543535101354831 no 240 0.0469393649504154 393 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_557 1315-0110 16.2 µM 1.67324837884599 0.0545691849184023 no 241 0.0471392050068652 344 6833801
SGTC_1143 3454-2408 5.08 µM 1.66771596674596 0.0551590726797267 no 242 0.047686062141953 256 X1143
SGTC_1946 st076057 65.1 µM 1.66402760857091 0.0555551306919547 no 243 0.0480534561139844 204 953009
SGTC_660 4031-1742 102 µM 1.66318867564187 0.0556455284122663 no 244 0.0481373368730249 390 6738706
SGTC_1319 1306-0155 43.7 µM 1.66066318912928 0.0559183586030953 no 245 0.0483905551911424 384 3122360
SGTC_1872 amphotericin b 148 nM 1.65927880157621 0.0560683621760193 no 246 0.0485298124318206 345 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_469 w7 172 µM 1.65839566574421 0.0561642189232851 no 247 0.0486188154301917 235 45115570 A P450 inhibitor.
SGTC_1447 4239-0816 81.9 µM 1.65730404453564 0.0562828834821727 no 248 0.0487290100088525 335 1341554
SGTC_987 1497-1013 404 µM 1.65590561149233 0.0564351886709112 no 249 0.048870467529535 295 1676435
SGTC_2692 st077426 47.7 µM 1.65280506524364 0.0567740316791569 no 250 0.0491852714448495 348 25238571
SGTC_528 3492-0019 172 µM 1.6493918755765 0.0571488926766277 no 251 0.0495336890393314 602 2869262
SGTC_2451 5856223 45.7 µM 1.6480294634457 0.057299065482037 no 252 0.0496733126346717 332 2179896
SGTC_1161 k007-0610 110 µM 1.6459551089551 0.0575283087402905 no 253 0.0498865008197859 472 5843850
SGTC_2207 7258803 200 µM 1.64526982382716 0.0576042000262659 no 254 0.0499570899593599 285 3666799
SGTC_278 4092-0821 23.9 µM 1.64414803415918 0.0577286015326264 no 255 0.0500728140041164 332 877900
SGTC_1278 0874-0585 172 µM 1.64348067937149 0.0578027083787891 no 256 0.0501417597910181 332 766306
SGTC_1035 k081-0041 55.2 µM 1.64157993698181 0.058014187463288 no 257 0.0503385441758296 366 731709
SGTC_189 3970-0742 2.116 µM 1.64068891352894 0.0581135330071652 no 258 0.0504310037183813 301 2891807
SGTC_3068 9116768 49.47 µM 1.63841144021 0.0583680696875086 no 259 0.0506679471326806 332 41904888
SGTC_2925 9010536 32.5 µM 1.63800857095036 0.0584131864720049 no 260 0.0507099529265709 441 2994177
SGTC_2794 7785382 27.27 µM 1.63689022241183 0.0585385723596243 no 261 0.0508267046488166 450 2205081
SGTC_268 camptothecin 39.6153 µM 1.63011529651025 0.0593026800037517 no 262 0.0515385656957101 478 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2948 9070189 9.45 µM 1.61590273993478 0.0609310334173142 no 263 0.0530576715737679 326 6473636 YDL196W YDL196W
SGTC_482 fipronil 114 µM 1.6150288024394 0.0610322914053734 no 264 0.0531522288309003 243 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_335 4077-0256 27.6 µM 1.61111096839007 0.0614878451536424 no 265 0.0535777690669662 407 3121989
SGTC_1217 1183-1422 255 µM 1.60933388704334 0.0616953522847017 no 266 0.0537716765488292 350 2849664
SGTC_2876 9059903 25.97 µM 1.6087018498754 0.0617692859879261 no 267 0.0538407755617014 369 6916095
SGTC_301 4119-0100 24.5 µM 1.60613033049937 0.0620708075465963 no 268 0.0541226384834814 426 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2849 9019321 12.99 µM 1.60510787388616 0.0621910135189325 no 269 0.0542350333921423 349 16489627
SGTC_63 0099-0242 26.702 µM 1.6046328698065 0.0622469195145067 no 270 0.0542873116423801 449 3898502 YLR359W ADE13
SGTC_2123 5259487 200 µM 1.60462056239426 0.0622483685663178 no 271 0.054288666707781 367 2173474
SGTC_2641 levomentholum 100 µM 1.60346167881788 0.0623849312791812 no 272 0.0544163815499368 284 16666
SGTC_365 0121-0052 13.6 µM 1.60296117489824 0.0624439827949068 no 273 0.0544716130516515 463 3101739
SGTC_1984 st072354 53.1 µM 1.60198312633765 0.0625595027833459 no 274 0.0545796704286216 333 5762938
SGTC_805 3852-0218 479 µM 1.60083691548521 0.0626950968297916 no 275 0.0547065224720803 378 6615355
SGTC_2279 7948423 32.93 µM 1.59838290101882 0.0629861710336233 no 276 0.0549788938374363 312 1247112
SGTC_483 fpl-64176 144 µM 1.59307448243299 0.0636194108086005 no 277 0.0555717415190927 280 3423
SGTC_373 0844-0104 25.9 µM 1.59141336595108 0.063818579207763 no 278 0.0557582891352422 384 5375804
SGTC_318 1488-0629 67.2 µM 1.58439985227568 0.0646648526381274 no 279 0.0565513777625717 342 3662576
SGTC_102 gallobenzophenone 83.616 µM 1.58230984533494 0.0649187180574519 no 280 0.0567894271395247 412 70837
SGTC_1825 st052143 62.6 µM 1.58077573745818 0.0651055523480758 no 281 0.0569646619969804 316 674173
SGTC_3064 1327-0027 10 µM 1.57896714834911 0.0653263505138594 no 282 0.0571717962410578 216 16000455 YPR107C YTH1
SGTC_2182 6325192 200 µM 1.57830465599601 0.0654073748403811 no 283 0.0572478183992972 345 736248
SGTC_124 0136-0217 7.121 µM 1.57725635748048 0.0655357433671149 no 284 0.0573682750012928 453 3976905
SGTC_1967 st070177 51.4 µM 1.57345449410504 0.0660029369870463 no 285 0.0578068086688927 341 5729214
SGTC_3313 9133968 57.047 µM 1.57298181785791 0.0660612019236402 no 286 0.0578615141815693 396 1494643
SGTC_1396 3511-0007 98.6 µM 1.56756508870884 0.0667317488253911 no 287 0.0584913324619466 336 X1396
SGTC_2534 helenine 20.12 µM 1.56441186208928 0.0671245109667023 no 288 0.0588604383812958 336 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2667 digitoxin 100 µM 1.56047466298219 0.067617430476103 no 289 0.0593238764624426 272 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_486 niguldipine 82 µM 1.55742680154706 0.0680009257143816 no 290 0.0596845934859198 332 1236 A calcium channel blocker.
SGTC_2899 9053889 58.44 µM 1.5552725178899 0.0682729985280272 no 291 0.0599405898259875 333 6470052
SGTC_514 4466-0038 2.65 nM 1.55200900869287 0.0686867589988007 no 292 0.0603300340358332 520 5722064
SGTC_82 0054-0107 293.755 µM 1.54881303955969 0.0690938279816282 no 293 0.0607133350204802 350 3104697
SGTC_2085 5307070 144.047 µM 1.54739820837134 0.0692746269166903 no 294 0.0608836265032366 344 2840351
SGTC_665 3914-0008 307 µM 1.54252946895837 0.0698995809609688 no 295 0.0614724912588775 405 1069549
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.54040312562516 0.0701738769452612 no 296 0.0617310600025683 466 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_197 4544-0043 41.561 µM 1.54014425982017 0.0702073268064277 no 297 0.0617625966331666 456 896523
SGTC_1854 st056233 32.9 µM 1.53394842189027 0.071011598825228 no 298 0.0625211710944973 369 5393174
SGTC_3000 9075062 71.4286 µM 1.5318495509098 0.0712856486617877 no 299 0.0627797825889406 379 17057871
SGTC_1407 3909-7909 12.3 µM 1.52510316253221 0.0721720258734945 no 300 0.0636166842717605 421 4411780
SGTC_1116 jasmonic acid 1.58368 µM 1.52498373404145 0.072187792789749 no 301 0.0636315774086673 420 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_887 0885-0007 9.62 µM 1.52497490020777 0.0721889591348776 no 302 0.0636326791253619 438 5719458
SGTC_938 3126-1755 342 µM 1.52495676841595 0.0721913531494717 no 303 0.0636349404887951 413 1777771
SGTC_2769 toremifene 3.73 µM 1.52372587421784 0.0723540154654464 no 304 0.0637886015834032 384 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2764 methyldopa 94.69 µM 1.52086154115165 0.0727336232543807 no 305 0.0641472934344613 434 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1339 1486-1321 22.7 µM 1.52055907553661 0.072773797639782 no 306 0.064185261641496 420 3469382
SGTC_2702 st077768 96.8 µM 1.52043781697961 0.0727899083333865 no 307 0.0642004880116856 383 6484119
SGTC_1102 cgs 12066b 26.1 µM 1.52009892520799 0.0728349487622648 no 308 0.0642430573532097 360 6438352 A 5-HT1B full agonist.
SGTC_2429 5902844 64.44 µM 1.51379930955334 0.0736760893815416 no 309 0.0650383739014072 429 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1145 3546-0597 10.2 µM 1.50449501177664 0.0749319794270822 no 310 0.0662269783879249 443 875334
SGTC_669 0108-0021 26.2 µM 1.49959185500219 0.0756003423111941 no 311 0.0668600794109996 553 17201
SGTC_560 2332-1943 155 µM 1.49756823529002 0.0758775079685739 no 312 0.06712273239987 406 21177716
SGTC_985 1493-0307 8.71 µM 1.49353374944329 0.0764324008802965 no 313 0.0676487633593634 354 3278274
SGTC_2 0422-0095 29 µM 1.49112452356179 0.0767652288072849 no 314 0.0679644024370531 315 6790840
SGTC_2342 7990637 118.86 µM 1.49068137218671 0.0768265687637645 no 315 0.0680225844989837 450 2033102 YER133W GLC7
SGTC_2798 7813637 45.45 µM 1.48656888657338 0.077397587911532 no 316 0.0685643551899811 442 956368
SGTC_1487 3970-0795 2.82 µM 1.48496975395944 0.0776204960584309 no 317 0.0687759182275143 438 3765103
SGTC_1121 fusaric acid 630.51 nM 1.48177767052226 0.0780669077109326 no 318 0.0691997312143059 451 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1804 st050076 49.1 µM 1.47592208527189 0.078890868730251 no 319 0.0699824049391322 440 3895976
SGTC_788 1182-0090 188 µM 1.47415176465168 0.0791412695609657 no 320 0.0702203668460406 569 5715185
SGTC_1924 st058459 75.1 µM 1.47387996687363 0.0791797668976947 no 321 0.0702569562398163 393 688683
SGTC_1685 st024049 53.0905 µM 1.4684231211249 0.0799556756731361 no 322 0.0709946624666583 385 1941139
SGTC_851 0394-0702 453 µM 1.46503881366997 0.0804397706350685 no 323 0.0714551642475303 466 762646
SGTC_448 monastrol 171 µM 1.45886151708375 0.0813290825519388 no 324 0.0723016134079276 422 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_626 0214-0009 33 µM 1.45884709315999 0.0813311677301601 no 325 0.0723035988105483 458 3437874
SGTC_3017 9080681 49.47 µM 1.45874090922857 0.0813465193313258 no 326 0.0723182159429198 430 16451914
SGTC_151 3013-0144 2.285 µM 1.45793044138777 0.0814637651911986 no 327 0.072429858430308 464 906558 YHR107C CDC12
SGTC_1654 st012436 41.8 µM 1.45446934278339 0.0819658975854984 no 328 0.0729081135420046 390 4323132
SGTC_2012 4023501 200 µM 1.45255475967216 0.0822446632302295 no 329 0.0731737073692767 427 3477460
SGTC_3105 9121040 49.47 µM 1.45060190411333 0.0825297363805237 no 330 0.0734453723953156 229 41448907
SGTC_1188 1403-0014 4.57 µM 1.44966055217008 0.0826674180797162 no 331 0.0735766006616049 517 9614867
SGTC_3096 9117468 49.47 µM 1.44960876886329 0.0826749968952949 no 332 0.0735838246627674 330 41316311
SGTC_1253 0550-0034 176 µM 1.44410428656085 0.0834835982612918 no 333 0.0743548212481045 433 5969915
SGTC_1090 efavirenz 20.7 µM 1.44377166758348 0.0835326493174638 no 334 0.0744016070909443 452 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_463 ikarugamyin 104 µM 1.44086609211562 0.0839620534951974 no 335 0.0748112585574709 342 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_413 propylparaben 100 µM 1.4407410740721 0.083980566570758 no 336 0.0748289231472806 420 7175 A pharmaceutical preservative.
SGTC_1496 4469-0713 57.4 µM 1.43370916707996 0.0850268157153142 no 337 0.0758276375469862 446 746691
SGTC_1617 st002906 78 µM 1.43361558004136 0.0850408057319791 no 338 0.0758409974707789 483 5150859
SGTC_1635 st007035 42.4 µM 1.43200448263654 0.0852819139181825 no 339 0.0760712692203607 671 3716403
SGTC_3100 9120536 49.47 µM 1.43194575235187 0.0852907128421839 no 340 0.0760796734962864 327 16421196
SGTC_2225 6654152 15.4 µM 1.42766198539259 0.0859343388926671 no 341 0.0766945864663772 364 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_496 calpeptin 138 µM 1.41785811853434 0.0874210143330716 no 342 0.0781160960175714 408 73364 A calpain inhibitor.
SGTC_1223 0764-0573 147 µM 1.41689536562814 0.0875680367102041 no 343 0.0782567608355016 512 1609797
SGTC_224 benfluorex 43.875 µM 1.41382589188089 0.0880380091221432 no 344 0.0787065146768985 340 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_384 k007-0144 5.16 µM 1.41218208337513 0.0882904674673332 no 345 0.0789481772754887 535 6824886
SGTC_1743 st037606 46.3785 µM 1.41179632104494 0.0883497914609503 no 346 0.0790049710192322 456 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1359 1582-0056 520 nM 1.4115638029226 0.088385563324583 no 347 0.0790392183743154 524 3661189
SGTC_3265 9137266 49.47 µM 1.4111378407579 0.0884511236752555 no 348 0.0791019870673242 399 17224265
SGTC_1333 1482-0047 286 µM 1.40993518103078 0.0886364220429227 no 349 0.0792794116663634 507 3811116
SGTC_380 3970-0968 6 µM 1.40826138257211 0.0888947915597576 no 350 0.0795268430848766 451 2891601
SGTC_1853 st056710 91.2 µM 1.40051573983707 0.0900977222798158 no 351 0.0806794666897041 486 269167
SGTC_966 1300-0360 30.2 µM 1.3985226271492 0.0904092084922357 no 352 0.0809780913635433 482 70588
SGTC_1830 st055982 50.3 µM 1.39537375780501 0.0909029463334923 no 353 0.0814515802601259 485 455313 An antimicrobial agent.
SGTC_1618 st003135 44.5 µM 1.39324922463853 0.0912371982124553 no 354 0.0817722195385205 462 1270615
SGTC_1182 1222-0449 220 µM 1.38934903848391 0.091853183428796 no 355 0.082363319407426 472 658318
SGTC_2874 9043904 71.43 µM 1.38827863465569 0.0920227777024128 no 356 0.082526107749255 392 4463428
SGTC_1603 st002045 67.8 µM 1.38787475779964 0.0920868279702242 no 357 0.0825875927365226 485 5887985
SGTC_1689 st020265 53.493 µM 1.38593284156458 0.0923952546934415 no 358 0.0828837057108997 478 5758320 YPR016C TIF6
SGTC_2917 7979103 53.79 µM 1.38448876033524 0.0926251073968068 no 359 0.0831044236595508 555 2980565
SGTC_1867 st057372 64 µM 1.38414653783941 0.0926796404884815 no 360 0.0831567947585121 488 688837
SGTC_1756 st041558 35.5 µM 1.38070028052512 0.0932301251241884 no 361 0.0836855675115897 531 3955792
SGTC_1611 st001856 99.4 µM 1.37730941375826 0.0937741163971497 no 362 0.0842083029936464 478 647478
SGTC_3136 9095672 49.47 µM 1.37687010735152 0.0938447647137268 no 363 0.0842762053341988 423 17217380
SGTC_798 1287-0182 476 µM 1.37594958403482 0.093992928699551 no 364 0.0844186212552041 539 1649755
SGTC_1442 4112-3290 3 µM 1.37419847127335 0.094275257645825 no 365 0.084690037613242 512 704353
SGTC_1964 st076914 61 µM 1.37180187756795 0.094662669529437 no 366 0.0850625613124839 458 24208661
SGTC_1454 4239-0054 42.6 µM 1.37103943336712 0.0947861651340032 no 367 0.0851813318656899 556 1340767
SGTC_331 k048-0133 24.5 µM 1.37040900625989 0.0948883671294026 no 368 0.0852796311332066 441 6813582
SGTC_3119 9125183 49.47 µM 1.37006652004931 0.0949439234709131 no 369 0.0853330688660036 359 22695334
SGTC_3010 9080089 71.4286 µM 1.36804258624203 0.0952727248520871 no 370 0.0856493731762296 485 17027233
SGTC_3049 9092223 49.47 µM 1.36722679717247 0.0954054919655039 no 371 0.0857771142040529 469 8623917
SGTC_1989 st071868 50.2 µM 1.36557641279678 0.0956745032233767 no 372 0.0860359770545987 517 16414057
SGTC_2117 5521686 200 µM 1.3607541208391 0.0964637298748405 no 373 0.0867957025136607 484 803312
SGTC_126 0417-1624 672.48 µM 1.36005720380968 0.0965781832855278 no 374 0.0869059112383592 628 41912 YDL195W SEC31
SGTC_908 3448-7491 47.7 µM 1.35900965175452 0.0967504084695832 no 375 0.0870717651383334 605 1203031
SGTC_648 0375-0473 33.3 µM 1.35722187892189 0.0970448520828965 no 376 0.0873553604490816 552 1713139
SGTC_789 1309-1135 70.6 µM 1.35613538280811 0.097224117465885 no 377 0.087528048410953 535 3092424
SGTC_1190 1486-1332 13 µM 1.3493260524884 0.0983531525414784 no 378 0.0886161305601854 491 4150046
SGTC_1630 st005209 31.3 µM 1.34597006453968 0.0989131184045283 no 379 0.0891560854947703 574 3367314
SGTC_910 3454-3003 490 µM 1.34591155194641 0.0989229022125512 no 380 0.0891655214284959 545 820824
SGTC_1979 st071809 45.3 µM 1.34493474898516 0.0990863366348269 no 381 0.089323153668723 498 4976333
SGTC_2520 obtusaquinone 4.71 µM 1.34472514486878 0.0991214324048759 no 382 0.0893570056749819 505 5967872
SGTC_2200 6600604 21.907 µM 1.34238990394636 0.0995130563539365 no 383 0.0897348032674681 548 2904777
SGTC_761 k216-0224 480 µM 1.34177477942886 0.0996164017187279 no 384 0.0898345160310135 557 1340404
SGTC_2121 5257820 149.641 µM 1.33950509087169 0.0999984043456777 no 385 0.0902031491240872 551 791256
SGTC_392 N-ethylmaleimide 8.33 µM 1.33807275076426 0.100240025946096 no 386 0.0904363612548385 496 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2774 tamoxifen 10.92 µM 1.33462032094202 0.100824167593426 no 387 0.0910003218506906 499 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1026 k007-1105 30.6 µM 1.33291948328719 0.101112855602703 no 388 0.0912791140312206 612 7066794
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.32813053760549 0.101928932140483 no 389 0.0920674933626873 494 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2946 9065502 71.43 µM 1.327060779922 0.102111880999655 no 390 0.0922442888851322 354 16489101
SGTC_593 1203-0218 61.7 µM 1.32379429193333 0.102671990668884 no 391 0.0927856861925974 541 3666956
SGTC_1553 gossypol 38.6 µM 1.32100768742736 0.103151576288273 no 392 0.0932494004931368 385 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3155 9099265 49.47 µM 1.31923442051819 0.103457608320294 no 393 0.0935453771535526 484 25236499
SGTC_2158 5657123 3.6195 µM 1.31652033061737 0.103927283817948 no 394 0.0939997296265715 507 2858827
SGTC_2057 5236571 38.335 µM 1.31313965873293 0.104514472067557 no 395 0.0945679461830673 571 54684039 YBR257W POP4
SGTC_2991 9074669 71.4286 µM 1.31308428804278 0.104524109356984 no 396 0.0945772738072034 610 17333109
SGTC_1477 0139-0234 16 µM 1.31286681352044 0.104561967109318 no 397 0.0946139156478593 532 620880
SGTC_2180 6301957 200 µM 1.3077859630713 0.105449265239053 no 398 0.0954729582826868 515 845462
SGTC_2752 diclazuril 33.15 µM 1.30719110128163 0.105553504443764 no 399 0.0955739084940667 714 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1768 st044301 37.178 µM 1.29950108886684 0.106907758819666 no 400 0.0968860100127436 562 3931349
SGTC_2480 5767542 37.17 µM 1.29761066341526 0.107242584477398 no 401 0.0972105780157552 540 2867358
SGTC_3226 9131256 49.47 µM 1.29492188934815 0.107720112371993 no 402 0.0976735882572314 399 17178073
SGTC_3324 9138759 60.749 µM 1.29232507979306 0.108182759616443 no 403 0.0981222950593248 538 45595710
SGTC_1642 st009582 77.7 µM 1.29170417063617 0.108293592278834 no 404 0.0982298062958253 509 6739311
SGTC_2662 daunorubicin 22.37 µM 1.29158337599804 0.108315163687177 no 405 0.0982507320686093 504 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1916 st067606 49.2 µM 1.27948641312239 0.110491114931358 no 406 0.100362910575103 609 19590279
SGTC_11 0438-0307 1.3 µM 1.27916747840335 0.110548904532877 no 407 0.100419042750901 533 4011476
SGTC_2286 7945697 125 µM 1.27700876532122 0.110940623740267 no 408 0.100799576356885 554 1245733
SGTC_320 4092-0846 5.34 µM 1.27285600354 0.111696976219523 no 409 0.101534571951239 565 1359356
SGTC_419 nsc-638432 893 µM 1.27203133107955 0.111847613763491 no 410 0.101680993726848 571 368090
SGTC_3336 9143619 71.43 µM 1.26915949307811 0.11237332750243 no 411 0.102192092492009 609 45595730
SGTC_1285 0929-0069 65.5 µM 1.26842874031298 0.112507379179144 no 412 0.102322441745451 568 1206237
SGTC_2714 st079313 56.9 µM 1.26772161369326 0.112637205511759 no 413 0.102448691723772 545 2939799
SGTC_1962 st076595 64.5 µM 1.26746810202095 0.1126837755409 no 414 0.102493981122125 568 279619
SGTC_447 ml7 120 µM 1.26698560248089 0.112772448567693 no 415 0.102580218999397 566 4216 Selective myosin light chain kinase inhibitor.
SGTC_1403 3909-7815 62.9 µM 1.26590710702002 0.112970832927244 no 416 0.102773170828655 512 6615483
SGTC_2964 9083345 53.42 µM 1.26411255420019 0.113301484631909 no 417 0.103094815604507 529 17741579
SGTC_1022 4477-0945 21.3 µM 1.26369793751366 0.11337797706748 no 418 0.103169232847998 579 4648966
SGTC_3297 9117502 71.43 µM 1.25807111224491 0.114419710758838 no 419 0.10418301976295 551 7453720
SGTC_344 k064-0035 6.43 µM 1.25754606269445 0.114517263329058 no 420 0.104277985189289 555 5088750
SGTC_457 grayanotoxin iii 135 µM 1.25671899360088 0.114671050239296 no 421 0.104427703952968 639 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1632 st005650 90 µM 1.25625789794214 0.114756851081036 no 422 0.104511240597221 564 2759605
SGTC_1546 5-methoxyflavanone 78.7 µM 1.25235347210841 0.115485219305508 no 423 0.105220546204142 615 147795
SGTC_1375 2910-0797 186 µM 1.24907450310861 0.116099441859481 no 424 0.10581891262058 574 742508
SGTC_426 0988-0037 14.6 µM 1.24530256934316 0.11680887108069 no 425 0.106510275790838 643 5383008
SGTC_316 k060-0003 58.6 µM 1.2449785769695 0.116869950908906 no 426 0.10656981255002 574 6152314
SGTC_2707 st078556 66.6 µM 1.24429113555843 0.116999623999124 no 427 0.106696216170019 570 17250899
SGTC_303 1348-1668 34.2 µM 1.24307428928823 0.117229409418026 no 428 0.1069202295814 557 5380509
SGTC_1482 3346-2049 8.48 µM 1.24294993851991 0.117252909416413 no 429 0.10694314083603 566 3826804
SGTC_2089 5281248 129.67 µM 1.24159642004782 0.117508915251003 no 430 0.107192751644542 591 2737878
SGTC_2363 9053361 176 µM 1.24064267989462 0.117689544125608 no 431 0.107368888957278 608 6469797 YMR079W SEC14
SGTC_493 zm226600 134 µM 1.24027262204391 0.117759682282692 no 432 0.107437287616652 601 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.23963678986231 0.117880262500513 no 433 0.107554883296942 639 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1808 st050063 61.5 µM 1.23953576657287 0.11789942875607 no 434 0.107573575854913 562 4011993
SGTC_3295 9122362 53.5725 µM 1.23571335978027 0.118626240705318 no 435 0.108282564892365 556 4730473
SGTC_531 3788-1495 174 µM 1.22987809485493 0.119741883662237 no 436 0.10937137909776 594 2896655
SGTC_132 0417-1715 25.805 µM 1.2272522215398 0.120246330200404 no 437 0.109863903619813 624 6769098
SGTC_2618 avocadyne 43.43 µM 1.22569774221219 0.120545659878244 no 438 0.110156220087249 577 3015189
SGTC_1903 st060211 78.3 µM 1.22546781760584 0.120589978536996 no 439 0.110199504229986 641 688960
SGTC_579 4491-1009 110 µM 1.22538519725615 0.120605906659236 no 440 0.110215060790052 759 1271041
SGTC_369 0957-0393 4.5 µM 1.22431275136119 0.120812794608309 no 441 0.110417134228455 550 6997992
SGTC_422 cantharidin 155 µM 1.22388687668086 0.120895020300675 no 442 0.110497452442368 598 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1379 2144-0755 36.5 µM 1.22013271868558 0.121621557763334 no 443 0.111207283565578 653 5392327
SGTC_768 0384-0033 77.3 µM 1.21614448866911 0.122396750516171 no 444 0.111964942829856 649 3965305 YMR134W ERG29
SGTC_2065 5221596 34.26 µM 1.21517279070562 0.122586143768689 no 445 0.112150097872141 600 788581
SGTC_1450 4112-4260 37.6 µM 1.21504732019224 0.122610614155449 no 446 0.112174021965021 632 1633175
SGTC_545 4218-0007 221 µM 1.21451823440359 0.122713838911196 no 447 0.112274945531662 587 2840508
SGTC_2526 patulin 37.61 µM 1.21424596868133 0.122766981762658 no 448 0.112326905731275 672 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_659 k018-0002 107 µM 1.21243905696747 0.123120077274308 no 449 0.112672178913373 623 6797879 YHR007C ERG11
SGTC_2909 7941780 10.49 µM 1.21193004495831 0.123219673628389 no 450 0.112769580002147 630 1243215
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.21055209795916 0.123489574288424 no 451 0.113033556222807 634 688798
SGTC_684 1140-0066 328 µM 1.21032254205123 0.123534577975194 no 452 0.113077575551344 664 6813534
SGTC_1246 0422-0085 105 µM 1.20984174575838 0.123628873740789 no 453 0.113169812034357 661 264295
SGTC_913 3487-1245 167 µM 1.20974812260151 0.123647241364486 no 454 0.113187779044939 611 4016153
SGTC_2551 apiole 73.87 µM 1.20915041889548 0.123764547957898 no 455 0.113302530997056 450 10659 A possible DNA adduct former.
SGTC_1305 1181-0477 144 µM 1.20152067867307 0.125268824594529 no 456 0.114774645008044 605 6252086
SGTC_1170 0310-0127 64.8 µM 1.19879261348251 0.125809774367392 no 457 0.115304297719997 639 774975
SGTC_2957 9076800 11.52 µM 1.19637236092159 0.126291049923345 no 458 0.11577564108618 559 16459615
SGTC_1969 st069479 40.1 µM 1.19492675825992 0.12657912427246 no 459 0.116057823621533 565 3895485
SGTC_1688 st021091 57.6 µM 1.1915533124295 0.12725315138678 no 460 0.116718220363983 620 3656366
SGTC_1316 1272-0050 65.9 µM 1.18797940501229 0.127969950968538 no 461 0.117420761871313 627 7340392
SGTC_1466 k213-0079 57.5 µM 1.1878324134667 0.127999492220903 no 462 0.117449720734573 637 3657981
SGTC_150 3970-0969 77.2 µM 1.18755416767679 0.128055424932833 no 463 0.117504551894893 715 6615640
SGTC_639 0833-0042 114 µM 1.18735872688986 0.128094722409166 no 464 0.117543076322128 667 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3178 9107506 49.47 µM 1.18395333723007 0.128780792330849 no 465 0.118215767398298 641 8897194
SGTC_2955 9076254 12.21 µM 1.18128998857747 0.129319139774567 no 466 0.118743771518881 590 16459619
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.17899253741307 0.129784779076311 no 467 0.119200573708119 696 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2284 7945075 39.21 µM 1.17768014656575 0.130051290244246 no 468 0.119462072340688 712 1245402
SGTC_96 0929-0093 37.281 µM 1.17680393119912 0.130229436673044 no 469 0.119636886590949 595 6991579
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.17636820338993 0.130318088856961 no 470 0.119723886044751 696 23847180
SGTC_499 genistein 192 µM 1.1743972674351 0.13071961245488 no 471 0.12011796963866 600 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2199 6590217 200 µM 1.17399824061178 0.130801007102721 no 472 0.120197865170358 566 703109
SGTC_2227 7312221 64.1025 µM 1.17382189090104 0.130836990587324 no 473 0.120233186890015 616 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2967 9089538 49.85 µM 1.17353809201477 0.130894913028944 no 474 0.120290045345779 667 728216
SGTC_3176 9106582 49.47 µM 1.17149509348939 0.131312405411292 no 475 0.120699914439398 474 17018027
SGTC_716 1683-5115 658 µM 1.17128777248825 0.131354823362389 no 476 0.120741562335147 735 723597
SGTC_1423 4048-0112 5.59 µM 1.16883459439358 0.131857462849526 no 477 0.121235139701475 648 X1423
SGTC_2052 5265182 7.135 µM 1.16513885636668 0.132617196786753 no 478 0.121981395335307 679 1239884
SGTC_897 1000-0139 31.4 µM 1.16427638804269 0.132794927767495 no 479 0.122156011108381 649 6151020
SGTC_1856 st057054 55.7 µM 1.16234373048726 0.133193790705742 no 480 0.122547935005623 684 1266018
SGTC_939 1165-0479 45.3 µM 1.16131013764497 0.133407442183872 no 481 0.12275789915061 661 1377347
SGTC_2699 st077704 54.6 µM 1.15741621772582 0.134214461332481 no 482 0.123551175634006 639 645852
SGTC_1194 1488-0194 225 µM 1.15588345147319 0.134533046663366 no 483 0.123864416197904 686 1391452
SGTC_2206 7254556 146.969 µM 1.15070648461409 0.135612914430524 no 484 0.124926503930444 611 4398905
SGTC_1239 0337-0584 35.4 µM 1.15033410353447 0.135690817993301 no 485 0.125003144819394 713 914301 YML130C ERO1
SGTC_2217 6934799 96.0675 µM 1.14995492137159 0.135770175862846 no 486 0.125081219202312 649 675606
SGTC_2077 5212015 200 µM 1.14966074721462 0.135831764560275 no 487 0.12514181371884 618 780900
SGTC_1758 st042942 75.2445 µM 1.14674304742636 0.13644365405114 no 488 0.125743916776208 680 669317
SGTC_1995 st072814 61.1 µM 1.14621734171207 0.136554103313011 no 489 0.125852617084444 647 5769371
SGTC_1077 5-fluorocytosine 377 nM 1.14454576967787 0.136905702030495 no 490 0.126198683894658 633 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2976 9009005 19.48 µM 1.14381475311654 0.137059658452505 no 491 0.126350235069189 665 2993148
SGTC_1 0258-0098 57.368 µM 1.14364791080304 0.137094813006469 no 492 0.126384841859797 581 6790032 YDR047W HEM12
SGTC_1159 4092-0538 61.2 µM 1.1427300847015 0.13728831395366 no 493 0.126575337417677 709 717301
SGTC_1906 st060206 94.7 µM 1.14234727548453 0.13736907491101 no 494 0.126654848855869 701 5133468
SGTC_1010 4112-3296 15.2 µM 1.14208652495064 0.137424103815634 no 495 0.126709027991643 696 704384
SGTC_641 4092-0595 30 µM 1.1414989316312 0.137548164931633 no 496 0.126831178166474 695 786260
SGTC_2457 5731572 11.68 µM 1.14137542968146 0.137574250152046 no 497 0.126856862442877 679 2865357
SGTC_1014 4130-3005 69.3 µM 1.14023487457227 0.137815309835878 no 498 0.127094230909743 681 743608
SGTC_272 doxorubicin 8.13 µM 1.13558782138294 0.138800456313113 no 499 0.128064554087676 728 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_515 4092-1064 102 µM 1.13406079749913 0.13912522027344 no 500 0.128384523157463 744 717353
SGTC_3255 9139072 49.47 µM 1.13220694188127 0.139520188641432 no 501 0.128773721149549 667 17646060
SGTC_455 paf C-16 10 µM 1.12755468437661 0.140514718884483 no 502 0.129754016844768 656 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3259 9138485 49.47 µM 1.12711456559383 0.140609053261221 no 503 0.129847022885206 750 17646153
SGTC_1318 1280-3875 124 µM 1.12655858654561 0.140728282383437 no 504 0.129964578524354 704 373245
SGTC_647 0140-0236 81 µM 1.12591610021592 0.140866148326391 no 505 0.130100516909732 771 990837
SGTC_2887 9044784 58.44 µM 1.12527807429014 0.141003147794996 no 506 0.130235608904413 726 6465546
SGTC_1510 1123-0200 71.5 µM 1.12449097106544 0.141172282204511 no 507 0.130402399362244 763 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1513 0337-0559 19 µM 1.12266328896414 0.141565548778924 no 508 0.130790262504584 614 775073
SGTC_3352 9151559 45.5865 µM 1.12204121246438 0.14169957156528 no 509 0.130922458714645 649 17159339
SGTC_547 1120-0019 610 nM 1.1205026560909 0.142031413688359 no 510 0.131249810684616 679 3676939
SGTC_3246 9135460 32.98 µM 1.12009280927624 0.142119899784937 no 511 0.131337107277182 595 41446951
SGTC_1292 0kpi-0043 232 µM 1.116328505287 0.14293435957292 no 512 0.132140772133847 662 3333905
SGTC_2670 beta-carotene 100 µM 1.11471257709492 0.143284953994773 no 513 0.132486804826136 607 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_204 PMA1.184 62.41 µM 1.11222539726733 0.143825710592245 no 514 0.133020625349619 747 2252213 YGL008C PMA1
SGTC_2153 5569715 200 µM 1.1115743005494 0.143967497556288 no 515 0.133160613675615 676 2054701
SGTC_3262 9137218 49.47 µM 1.11069228555907 0.144159721064397 no 516 0.133350411975482 544 17650664
SGTC_1927 st060202 13.8 µM 1.10932065655559 0.144458993122745 no 517 0.133645938521837 691 688887
SGTC_1955 wogonin 32.4 µM 1.10927072333854 0.144469895809599 no 518 0.133656705452452 672 5281703 A flavanone.
SGTC_688 0527-0193 473 µM 1.10919520018127 0.144486386994954 no 519 0.133672991388449 665 4007154
SGTC_714 4296-0578 26.1 µM 1.10832115921144 0.144677334271951 no 520 0.133861570267219 651 1589775
SGTC_521 r062-0005 13.8 µM 1.10767061395228 0.144819565867377 no 521 0.134002047425347 674 2832033
SGTC_810 3825-7150 143 µM 1.10685409533777 0.144998218167507 no 522 0.13417850777833 749 22330411 YGL099W LSG1
SGTC_941 3237-0776 460 µM 1.10637221152235 0.145103722767275 no 523 0.134282724039188 663 760008
SGTC_1438 4092-1045 4 µM 1.10553258494728 0.145287675688904 no 524 0.134464441552982 713 1351342
SGTC_1076 itraconazole 331 nM 1.10541971671335 0.145312415831946 no 525 0.134488882106297 711 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_625 k213-0058 121 µM 1.10502628590715 0.145398676021729 no 526 0.134574099685171 879 3655420
SGTC_2061 5245884 80.95 µM 1.10494508832826 0.145416482978045 no 527 0.134591691790008 703 573863
SGTC_889 0919-1524 82.7 µM 1.10461966946079 0.145487863366689 no 528 0.134662212229586 665 3905452
SGTC_2820 7989630 71.43 µM 1.10418805977223 0.145582572981518 no 529 0.134755784043203 586 2984098
SGTC_1094 duloxetine 25.4 µM 1.10363436192355 0.145704133519056 no 530 0.134875889555709 690 60834 A selective serotonin reuptake inhibitor.
SGTC_3101 9120531 49.47 µM 1.10137829177171 0.146200143423262 no 531 0.135366024681467 712 24824904
SGTC_2808 7946468 45.46 µM 1.10052683395201 0.146387635711731 no 532 0.135551322278047 742 2970879
SGTC_934 2950-0684 338 µM 1.10046161960474 0.146402002661501 no 533 0.135565521642264 739 1121253
SGTC_1878 temozolomide 1 mM 1.09690382864699 0.147187231183711 no 534 0.136341717455997 683 5394 DNA alkylating agent.
SGTC_1240 0356-0016 42.1 µM 1.09109165954905 0.148476079465009 no 535 0.137616276220558 707 4305613
SGTC_1806 st050005 60.3 µM 1.08983510975041 0.148755708536915 no 536 0.137892892499609 693 5194765
SGTC_1892 st058411 7.36 µM 1.0897003238411 0.148785724304979 no 537 0.137922586715965 778 3934738
SGTC_1082 camptothecin 424.86 nM 1.08827264435562 0.149103905860886 no 538 0.13823738163278 624 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1328 1441-0025 69.2 µM 1.08796067082459 0.149173494690171 no 539 0.138306235120802 681 4562601
SGTC_1524 corynanthine 62.1 µM 1.08049772621145 0.150844644994475 no 540 0.139960299391066 696 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3071 9117417 49.47 µM 1.08012645072511 0.150928107546803 no 541 0.14004293731489 625 45595590 YGL055W OLE1
SGTC_2067 5224629 34.075 µM 1.07962715511806 0.151040397414273 no 542 0.140154122020515 699 2835000
SGTC_2264 7948757 110.76 µM 1.07781969244974 0.151447354348518 no 543 0.140557114812791 688 2971411
SGTC_2983 9022671 12.99 µM 1.07435060189281 0.152230473756016 no 544 0.141332786754504 702 6405161
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.07255199796049 0.152637550621124 no 545 0.141736085943302 744 229346 A bile salt which induces apoptosis.
SGTC_2453 5731132 22.18 µM 1.07244301271204 0.152662240365397 no 546 0.141760548619981 783 1362040
SGTC_3040 9091894 49.47 µM 1.07116586638111 0.152951765165388 no 547 0.14204742819764 659 25236966
SGTC_2305 7443522 69.23 µM 1.07079484546703 0.15303594256124 no 548 0.142130842554524 782 5415886
SGTC_2886 9058944 51.95 µM 1.06853681771248 0.153548907021257 no 549 0.142639215863595 569 4949929
SGTC_417 st075190 100 µM 1.06666748737051 0.153974430200328 no 550 0.1430610068291 768 222757
SGTC_2593 nobiletin 86.24 µM 1.06613963917623 0.154094727545687 no 551 0.143180261574185 676 72344 An anti-infammatory.
SGTC_2932 9016711 44.54 µM 1.06541217724212 0.154260619005981 no 552 0.143344724307602 782 7117328
SGTC_3340 9146634 11.102 µM 1.06191531478735 0.155059696362553 no 553 0.144137065942006 749 4907387
SGTC_2265 7929201 200 µM 1.06124764393495 0.155212577799726 no 554 0.144288686211289 730 1265108
SGTC_170 4197-0004 226 µM 1.06058480048113 0.155364452262771 no 555 0.144439316542601 679 218692
SGTC_3086 9117350 49.47 µM 1.0591360362025 0.155696742681944 no 556 0.144768915183593 682 2679265
SGTC_2811 7967822 32.47 µM 1.05814894752465 0.155923410854476 no 557 0.144993771002099 740 2232244
SGTC_1157 4092-0394 27.6 µM 1.05750602570754 0.156071163868618 no 558 0.145140353016805 803 3659885
SGTC_2239 6685329 187.64 µM 1.05670104426599 0.156256290642319 no 559 0.145324024133918 740 805680
SGTC_295 k015-0027 31 µM 1.0538046713163 0.156923584366314 no 560 0.145986177192636 748 3887424
SGTC_973 1325-0077 65.9 µM 1.05304566259935 0.157098761527935 no 561 0.146160032335525 809 2835149
SGTC_1763 st044482 94.5 µM 1.04994253542147 0.157816292181804 no 562 0.146872266854756 774 88505
SGTC_2825 7998094 58.44 µM 1.04884839963785 0.158069799716705 no 563 0.14712394879291 724 2987815
SGTC_588 3970-1144 52.9 µM 1.0466035980544 0.15859074896197 no 564 0.147641220880521 764 1888707
SGTC_2167 5876490 200 µM 1.04244706197989 0.159558321862145 no 565 0.148602228446337 777 686534
SGTC_2810 7959871 45.46 µM 1.04122985659847 0.159842397030596 no 566 0.148884441028275 811 2974535
SGTC_3107 9121808 49.47 µM 1.03945556330474 0.160257079366092 no 567 0.14929645714991 717 662681
SGTC_1500 4488-1866 171 µM 1.03607343232673 0.161049486477778 no 568 0.150083942827773 819 2900003
SGTC_1215 3852-0577 11.2 µM 1.0355061490336 0.161182646544507 no 569 0.150216298136168 836 2884876
SGTC_2025 5147754 141 µM 1.03469985465799 0.161372033950821 no 570 0.150404551975745 761 315777 YLR208W SEC13
SGTC_106 0092-0003 11.579 µM 1.03421332520521 0.161486383174507 no 571 0.150518223018728 697 1072148
SGTC_1263 0774-1208 64.8 µM 1.03068629244846 0.16231692253759 no 572 0.151343977436879 847 906585
SGTC_601 0986-0029 62.9 µM 1.03011292077966 0.162452201365401 no 573 0.151478500268446 803 24747981
SGTC_231 b-estradiol 524 µM 1.02855980300366 0.162819005686817 no 574 0.151843287573492 694 450 A steroid.
SGTC_171 k064-0041 9.68 µM 1.0275972132305 0.163046613439463 no 575 0.152069667820017 662 53325
SGTC_858 0438-0351 2.77 µM 1.02719130582482 0.163142653644095 no 576 0.152165195596048 823 2799119
SGTC_460 trequinsin 123 µM 1.02589676164821 0.163449196358955 no 577 0.15247012462847 846 5537 A vasodilator.
SGTC_2228 7354201 200 µM 1.02118477600803 0.164568131920429 no 578 0.15358345188153 794 753451
SGTC_2478 5763493 32.33 µM 1.02026993517814 0.164785949455616 no 579 0.153800228929087 801 1365576 YLR208W SEC13
SGTC_3002 9075603 71.4286 µM 1.01755145200088 0.165434303696563 no 580 0.154445584428034 791 20105405
SGTC_518 1021-0119 62.6 µM 1.01562484023889 0.165894795631303 no 581 0.154904035658246 738 1097762
SGTC_998 3996-0085 177 µM 1.01558941667099 0.165903270196287 no 582 0.154912473359479 870 715391
SGTC_720 r052-1644 49.9 µM 1.01304660965522 0.166512330060321 no 583 0.155518949163279 699 1422863 YOR257W CDC31
SGTC_1273 0849-0096 14.1 µM 1.01228479370872 0.166695082871654 no 584 0.155700951684931 782 5286025
SGTC_427 1354-0053 47.3 µM 1.01149438599183 0.166884831348254 no 585 0.155889933370016 770 6813657
SGTC_393 acivicin 6.25 µM 1.01072043746155 0.167070763514065 no 586 0.156075126224981 727 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2739 tacrine 100.86 µM 1.01058036306797 0.16710442903376 no 587 0.156108659157466 743 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1067 clotrimazole 1.36 µM 1.00950534851377 0.167362943919754 no 588 0.15636616892763 804 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2941 9056145 11.23 µM 1.00920216705936 0.167435898262086 no 589 0.156438843782422 714 2119517
SGTC_3165 9101544 49.47 µM 1.00661344130245 0.168059655794036 no 590 0.157060286319506 801 5002184
SGTC_3034 9090421 49.47 µM 1.00614921469251 0.168171669846186 no 591 0.157171898768599 760 17173761
SGTC_1123 mangostin 811.285 nM 1.00508072411643 0.168429670275412 no 592 0.157428990509309 765 5281650 An antioxidant.
SGTC_836 0330-0104 1.35 µM 1.00445077729934 0.168581898023157 no 593 0.157580692765437 793 46494820
SGTC_1945 st075991 56.6 µM 1.00395825189799 0.168700979235139 no 594 0.157699368416314 720 1084980
SGTC_615 k087-0205 167 µM 1.00137087009093 0.169327435788059 no 595 0.158323770868216 754 9642773
SGTC_1875 nocodazole 6 µM 1.00074150095964 0.169480044056177 no 596 0.158475898927632 813 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2027 5150920 200 µM 1.00010189705811 0.169635224424366 no 597 0.158630599082673 790 786715
SGTC_813 k007-0158 173 µM 0.998641156227635 0.169989970270788 no 598 0.158984277737692 870 6523916
SGTC_3126 9127922 49.47 µM 0.997623732632946 0.170237335780723 no 599 0.159230924228855 777 45595682
SGTC_2068 5226020 147 µM 0.997098256705126 0.170365184657141 no 600 0.159358409568017 837 1810509
SGTC_26 0302-0163 425.158 µM 0.997069925406613 0.170372079440363 no 601 0.159365284902349 807 3100915
SGTC_2982 9019404 25.97 µM 0.996622996802725 0.170480868870001 no 602 0.159473769574472 671 22333232
SGTC_886 0866-0150 153 µM 0.996613762298636 0.170483117162055 no 603 0.15947601161025 859 271463
SGTC_872 0588-0139 234 µM 0.996596954264206 0.170487209403488 no 604 0.159480092468651 818 2047100
SGTC_1355 1499-0035 1.68 µM 0.995266651403331 0.170811296891964 no 605 0.159803296337972 782 1548538
SGTC_2827 7993847 71.43 µM 0.989980763161068 0.17210293383464 no 606 0.161091760853415 733 2985692
SGTC_141 0443-0274 32.331 µM 0.988449407477472 0.172478290930733 no 607 0.161466300218804 923 1627241
SGTC_550 4123-0385 25.7 µM 0.98751227176975 0.172708253572229 no 608 0.161695784950812 800 5731123
SGTC_870 0573-2213 57.6 µM 0.984481718150704 0.173453254883097 no 609 0.162439358001482 788 3916321
SGTC_1199 1638-0010 4.46 µM 0.984434485138319 0.173464882344645 no 610 0.162450964621805 812 3111136
SGTC_708 3448-5400 146 µM 0.982783370254956 0.173871652932207 no 611 0.162857034081268 811 3462195
SGTC_1414 3917-0015 5.4 µM 0.97933636262471 0.174722815097352 no 612 0.163706904591991 829 6618702
SGTC_2397 5161689 200 µM 0.978780972605366 0.174860203384473 no 613 0.163844106570176 845 2259942
SGTC_2394 5221648 200 µM 0.9777198473237 0.175122887311718 no 614 0.164106451389561 916 788586
SGTC_680 0417-1641 114 µM 0.97680615118944 0.175349275278849 no 615 0.164332565105253 779 2835990
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.975550199154438 0.175660767224379 no 616 0.164643706889586 771 77254
SGTC_2836 9010338 19.48 µM 0.975192680344782 0.175749500465348 no 617 0.164732346135793 754 2994051
SGTC_183 3914-0051 30.55 µM 0.974282475900065 0.1759755338961 no 618 0.164958151640651 847 1596232
SGTC_2129 girgensonine 121.053 µM 0.971925998727567 0.176561578701255 no 619 0.165543682323072 875 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_85 0868-0259 160.055 µM 0.969379126492415 0.177196360088024 no 620 0.16617803150525 789 83173
SGTC_98 0074-0023 107.663 µM 0.968551813516785 0.17740286901257 no 621 0.166384427678794 858 3563821
SGTC_1276 0871-0068 94.2 µM 0.968535074242227 0.177407048937967 no 622 0.166388605462925 824 3414906
SGTC_3222 9128301 49.47 µM 0.967403348670098 0.177689793701234 no 623 0.166671218349197 849 4911358
SGTC_3319 9138450 16.7555 µM 0.965853339691283 0.178077501432325 no 624 0.167058786724266 798 2029690
SGTC_244 nsc-207895 1.295 µM 0.96198824621387 0.179046608119725 no 625 0.168027754078822 728 42640
SGTC_1530 rhein 70.4 µM 0.961952457835653 0.17905559692558 no 626 0.168036742985246 893 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_806 3966-4455 5.86 µM 0.961278908459244 0.179224822242759 no 627 0.168205974960888 741 714982
SGTC_2648 atorvastatin 78.68 µM 0.960713242907812 0.17936702006899 no 628 0.16834818537382 823 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2671 danthron 100 µM 0.960503724687839 0.179419707060806 no 629 0.16840087864899 830 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2379 9035213 200 µM 0.960223105712762 0.179490288811955 no 630 0.168471470189218 907 646551
SGTC_1787 fluconazole 80 µM 0.958732056477924 0.179865612678418 no 631 0.168846872462853 852 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1669 st015249 58.4 µM 0.957939450037201 0.180065326468707 no 632 0.169046646030512 905 722793
SGTC_3111 9122088 49.47 µM 0.957569375782342 0.180158622085937 no 633 0.169139973863726 728 16876704
SGTC_2861 9024595 19.48 µM 0.95735767952505 0.180212004294248 no 634 0.169193375733611 782 16482810
SGTC_2819 7996655 46.38 µM 0.957053916165144 0.180288619866791 no 635 0.169270021086337 739 6456960
SGTC_1710 st031758 61.5 µM 0.956266252922925 0.180487380471203 no 636 0.169468867522021 832 5394341
SGTC_1270 0831-1170 17.3 µM 0.955715510224817 0.180626437667082 no 637 0.169607992118669 909 6764716
SGTC_771 0250-0039 27.3 µM 0.954455902645432 0.18094472884246 no 638 0.169926460314581 818 3005115
SGTC_149 3970-0822 46.1 µM 0.953817403753322 0.181106205761127 no 639 0.170088039127466 961 3114250 YBL034C STU1
SGTC_3251 9135047 49.47 µM 0.953460793481464 0.181196432083107 no 640 0.170178325922119 842 17682963
SGTC_712 r015-0009 80.6 µM 0.951867284700941 0.181599951233255 no 641 0.170582146520282 807 6813872 YLR060W FRS1
SGTC_250 brefeldin a 552.239 µM 0.94929246238319 0.182253152701858 no 642 0.171235943058934 754 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1475 4092-1048 11.7 µM 0.947925811303644 0.18260045139876 no 643 0.17158361188259 883 2881759
SGTC_757 1066-0008 322 µM 0.946422778080783 0.18298288492678 no 644 0.171966496000319 885 6842497
SGTC_2415 st077333 57.7 µM 0.945595186318276 0.183193671538744 no 645 0.172177550197453 942 2766255
SGTC_2784 7567673 72.73 µM 0.944506442730016 0.183471203767729 no 646 0.172455455545083 886 3471247
SGTC_2906 7926292 26.41 µM 0.943883567585751 0.183630099011272 no 647 0.172614575038259 844 2966319
SGTC_2972 9093619 59.92 µM 0.941506004140534 0.184237402656946 no 648 0.173222806918161 826 25236256
SGTC_2022 5136654 200 µM 0.941297362524066 0.184290755805076 no 649 0.173276246992925 829 1713771
SGTC_3261 9137475 49.47 µM 0.940815722045082 0.184413956033714 no 650 0.173399651261138 678 17027690
SGTC_1871 st057448 67.3 µM 0.938359961475508 0.185042918525196 no 651 0.174029727343479 906 691747
SGTC_2523 spermine 47.74 µM 0.932178608814613 0.186631959018423 no 652 0.175622114225392 874 1103 A DNA binding polyamine.
SGTC_916 4466-0038 42 nM 0.931953557909745 0.186689971813549 no 653 0.175680263563425 969 5722064 YGL116W CDC20
SGTC_1891 st059073 26.2 µM 0.929343463667248 0.187363607610917 no 654 0.176355558616731 974 688754
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.928316687269466 0.187629018285791 no 655 0.176621660237492 839 279621
SGTC_1713 st033146 12.748 µM 0.92685547361693 0.188007126593661 no 656 0.177000789088778 877 674619
SGTC_996 3970-0799 1.8 µM 0.926184650492161 0.188180868354793 no 657 0.177175014034227 1071 6615648 YGL040C HEM2
SGTC_2587 piperic acid 92.2 µM 0.924749357435104 0.188552938846774 no 658 0.177548149374003 799 5370536
SGTC_2375 9072683 200 µM 0.924723405652319 0.1885596704902 no 659 0.177554900660555 977 16798029
SGTC_2981 9013952 38.96 µM 0.924495111422994 0.188618894207855 no 660 0.177614297772367 803 2996344
SGTC_2328 6201408 200 µM 0.923847003433873 0.188787087809162 no 661 0.177782989461624 835 2890418
SGTC_1778 st046819 58.9 µM 0.922200908432193 0.189214689120872 no 662 0.17821189466988 950 671715
SGTC_719 2810-4230 27.3 µM 0.919722200351333 0.189859699917014 no 663 0.178858974132428 866 721079
SGTC_1766 st045414 44.774 µM 0.916921406899987 0.190590148619695 no 664 0.179591912766543 949 253960
SGTC_62 0180-0423 3.232 µM 0.916553466661512 0.190686235707504 no 665 0.179688338993785 876 30102 YGL099W LSG1
SGTC_2185 6113692 200 µM 0.914995070295708 0.191093538327626 no 666 0.180097109053165 821 874150
SGTC_1431 4049-0260 9.09 µM 0.912389558309621 0.191775705700982 no 667 0.180781842115375 901 3854841
SGTC_1563 conessine 56.1 µM 0.910849461350709 0.192179629553616 no 668 0.181187348670315 1018 441082 An anti-amoebic, histamine inhibitor.
SGTC_1862 st057513 3.81 µM 0.910581027652196 0.192250085342179 no 669 0.181258085353024 902 5393163
SGTC_168 3970-0862 530.542 µM 0.910095817825814 0.192377478440649 no 670 0.181385989978441 1012 3135186
SGTC_1504 k297-0033 30 µM 0.908974151700304 0.192672172323656 no 671 0.181681885073948 771 4388117
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.908588689486076 0.192773507967086 no 672 0.181783639548688 931 165521
SGTC_2845 9003024 42.97 µM 0.90835135907424 0.192835916865032 no 673 0.181846307858039 913 2990173
SGTC_1415 3966-0071 78.1 µM 0.907901975695424 0.19295412145766 no 674 0.181965006850932 893 2893185
SGTC_95 0471-0001 561.058 µM 0.90420670401662 0.193927792871714 no 675 0.18294290301068 886 4015405
SGTC_61 0978-8327 98.565 µM 0.901762771531606 0.194573389429069 no 676 0.183591449959815 930 6150059 YHR072W ERG7
SGTC_2736 butenafine 14.65 µM 0.900834144856459 0.194819040753008 no 677 0.183838255022727 928 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1080 nisoldipine 24.4 µM 0.900520794796093 0.194901974367399 no 678 0.183921582010787 921 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_139 0099-0334 718.624 µM 0.900194882499815 0.194988255572375 no 679 0.184008274535723 1038 97690
SGTC_2489 cantharidin 73.42 µM 0.897833508050237 0.195614093358606 no 680 0.184637158826891 900 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2701 st077767 14.721 µM 0.897046761446451 0.195822876274559 no 681 0.184846982658851 930 5721188
SGTC_1198 1612-1005 86.7 µM 0.893562289393105 0.196749192922017 no 682 0.185778065347504 934 6998509
SGTC_940 3232-1287 54.8 µM 0.892170331992873 0.19711997328816 no 683 0.186150820793249 925 1585493 YIL048W NEO1
SGTC_2127 5253358 187.912 µM 0.891876130526455 0.197198394815314 no 684 0.186229664976122 823 20612
SGTC_1560 lithocholic acid 53.1 µM 0.891570573232354 0.197279863300258 no 685 0.186311574355035 866 9903 A bile acid which acts as a detergent.
SGTC_1445 4239-0156 97.7 µM 0.887579077487433 0.19834595538996 no 686 0.187383606102511 1007 4008346
SGTC_3131 9127911 49.47 µM 0.886709365932764 0.198578707877594 no 687 0.187617697267942 868 45595681
SGTC_3314 9135860 59.4275 µM 0.885121997226593 0.199003944505973 no 688 0.188045418291672 971 25252478
SGTC_1220 1838-0075 193 µM 0.884130416596003 0.199269855030606 no 689 0.188312907697558 932 5529645
SGTC_3157 9099274 49.47 µM 0.883444674657701 0.199453874399349 no 690 0.18849803109637 919 17217662
SGTC_1583 clindamycin 39.6 µM 0.882890122852786 0.199602763583764 no 691 0.188647820355281 824 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1679 SEC14.276 6.7 µM 0.882299262296121 0.199761474719333 no 692 0.188807497640772 988 1005053 YMR079W SEC14
SGTC_1147 3809-1045 12.3 µM 0.881820585835117 0.199890107715597 no 693 0.188936918754133 901 325925
SGTC_3047 9092122 49.47 µM 0.880435178944484 0.20026268372676 no 694 0.189311803050626 896 17173831
SGTC_2360 9040895 200 µM 0.880104302208442 0.200351727749664 no 695 0.189401404362833 875 4914414
SGTC_2785 7756463 72.73 µM 0.874363771735089 0.201900375981431 no 696 0.190960090108671 954 2201551
SGTC_409 arachidonic acid 100 µM 0.87006040308438 0.203066000725538 no 697 0.192133697730954 940 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_780 0109-0199 192 µM 0.868810725660745 0.203405243865941 no 698 0.192475332789316 994 610414
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.867186722844784 0.20384660794623 no 699 0.19291985490231 867 521171
SGTC_857 0438-0306 1.35 µM 0.866942832916491 0.203912940502621 no 700 0.192986666575365 959 4686136
SGTC_2329 6138490 200 µM 0.866585980318445 0.204010019532011 no 701 0.193084448916826 812 720019
SGTC_2675 theaflavin digallate 100 µM 0.866231876026831 0.204106378119324 no 702 0.193181508080651 972 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3045 9092950 49.47 µM 0.86465650832932 0.20453539444759 no 703 0.193613673572859 975 44120432
SGTC_2373 9071805 200 µM 0.864511070256785 0.204575028308573 no 704 0.193653600832111 979 10149009
SGTC_1398 3558-0053 112 µM 0.863111532645725 0.204956654938782 no 705 0.194038073863501 899 4532369
SGTC_2792 7535235 81.82 µM 0.861137946374791 0.205495532092123 no 706 0.194581035952994 880 1281891
SGTC_2168 5727979 200 µM 0.860403868382864 0.205696182608945 no 707 0.194783227087911 901 695210
SGTC_2850 9015429 58.44 µM 0.859721350419158 0.205882844147182 no 708 0.194971331362824 923 6457570
SGTC_2419 paclitaxel 166.5 µM 0.858479053322685 0.206222857234277 no 709 0.195313996027012 992 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1492 4158-0558 28.5 µM 0.857979900772616 0.20635956751604 no 710 0.195451781000526 955 3967268
SGTC_2076 5212012 200 µM 0.85681255522679 0.206679495275623 no 711 0.195774242901215 871 604802
SGTC_2910 7948405 25.97 µM 0.856709965219664 0.206707625569112 no 712 0.195802597296927 937 2971328
SGTC_2934 9036370 36.88 µM 0.856425361732462 0.2067856760276 no 713 0.195881270635365 987 6462800
SGTC_3269 9137823 49.47 µM 0.855026830778331 0.207169466518398 no 714 0.196268147133285 887 17682936
SGTC_1310 1188-0297 994 nM 0.852108188206267 0.207971767977686 no 715 0.19707702386836 954 1588352
SGTC_3006 9075424 71.4286 µM 0.852095572116408 0.207975239973467 no 716 0.197080524682776 934 7465181
SGTC_1330 1469-0054 61.8 µM 0.851829325186824 0.208048520119504 no 717 0.197154413806676 1026 7102664
SGTC_2351 9026858 72.31 µM 0.849183364357166 0.208777605885327 no 718 0.19788963427108 925 1409300
SGTC_479 n-linoleoylglycine 10 µM 0.848415206526854 0.208989550904269 no 719 0.198103388430455 928 6433346 An anti-infammatory.
SGTC_2205 7238770 200 µM 0.847845341208778 0.209146866214997 no 720 0.198262054060324 978 279867
SGTC_2406 ethylparaben 405.7 µM 0.847512622694942 0.209238747718447 no 721 0.198354727180612 818 8434 A possible steroid mimic.
SGTC_2028 5153890 36.43 µM 0.8474651686105 0.209251854283109 no 722 0.19836794684375 948 2830968 YPR165W RHO1
SGTC_1028 k015-0029 4.8 µM 0.846036820161285 0.209646582632746 no 723 0.198766102069891 1020 4588309
SGTC_2029 5175081 200 µM 0.844488837953745 0.210074866183505 no 724 0.199198149067652 1035 1380876
SGTC_140 0062-0056 502.533 µM 0.843854156455675 0.210250613347479 no 725 0.199375454171441 1048 3758964
SGTC_1098 clofazimine 15.1 µM 0.843809330875909 0.210263029086538 no 726 0.199387980270776 995 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1779 st039427 55 µM 0.84159275065934 0.21087751186419 no 727 0.20000797422676 1068 1124498
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.840838096033656 0.211086958090515 no 728 0.200219320936863 1062 5024745
SGTC_978 1416-0512 87.4 µM 0.84071253080447 0.211121819188681 no 729 0.200254499443204 1002 6814003
SGTC_1581 himbacine 57.9 µM 0.840064558621829 0.211301771517096 no 730 0.200436095141124 950 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2890 9046729 58.44 µM 0.838047565114082 0.211862498005721 no 731 0.201001995035967 907 903329
SGTC_584 0986-0246 15.4 µM 0.835571746358853 0.212551967147627 no 732 0.201697934459061 1101 53315 YDR232W HEM1
SGTC_1605 st000082 49.1 µM 0.835006024426694 0.212709693853841 no 733 0.20185715819753 1003 1114022
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.833209687127763 0.213210976375357 no 734 0.202363240093139 1041 676296 Flavone; oxidizing agent.
SGTC_2186 6124449 200 µM 0.832845296122296 0.213312746632993 no 735 0.202465992424848 987 3834182 YLR033W RSC58
SGTC_838 0109-0203 71.4 µM 0.832106911078174 0.213519055987021 no 736 0.202674300612984 994 759422
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.831225233609894 0.213765554385433 no 737 0.202923201192025 987 2724 A muscle relaxant with antifungal properties.
SGTC_1264 0783-0040 158 µM 0.830778696631924 0.213890459893417 no 738 0.203049329732002 940 2855798
SGTC_2644 guaiazulene 100 µM 0.829920062725153 0.214130756703012 no 739 0.20329199040423 1025 3515 A coloring agent.
SGTC_1011 4112-3381 17.4 µM 0.829257917354345 0.214316171575997 no 740 0.203479239096799 969 2877139
SGTC_790 1575-0012 79.1 µM 0.829214066470794 0.214328454057851 no 741 0.203491643359375 1037 378741 YLR208W SEC13
SGTC_828 2074-0507 139 µM 0.828261046822148 0.214595492711133 no 742 0.203761338984072 1021 X828
SGTC_2107 5363541 170.161 µM 0.826454843197551 0.215102126043955 no 743 0.204273061908788 1013 244052
SGTC_2839 9003951 25.97 µM 0.826393837927994 0.215119249907273 no 744 0.204290358909514 986 2990634
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.82463692598081 0.215612745480919 no 745 0.204788875352809 1018 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_957 1187-1561 14.1 µM 0.822969669625631 0.216081664357611 no 746 0.205262620799962 1028 1538454
SGTC_1633 st005664 67.9 µM 0.821293400395614 0.216553713055505 no 747 0.205739582982091 1045 2063822
SGTC_1392 3455-1037 33.9 µM 0.820017318319293 0.216913465982177 no 748 0.206103117270197 988 981132
SGTC_1065 prochlorperazine maleate 2.48 µM 0.819265400624184 0.217125608196245 no 749 0.206317504175207 1058 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2161 5662504 8.5105 µM 0.817567559243153 0.217605069154722 no 750 0.206802078879152 961 2859334
SGTC_2149 5554786 194.827 µM 0.817249539768541 0.217694943976552 no 751 0.206892918515936 1044 745063 YPR165W RHO1
SGTC_1944 st076371 56.9 µM 0.81698659612099 0.217769270105222 no 752 0.206968044030233 964 24208455
SGTC_854 0422-0053 192 µM 0.816423377916855 0.217928523919018 no 753 0.207129015166567 1047 3596728
SGTC_2093 5331342 194.4 µM 0.816021772570708 0.21804212159169 no 754 0.207243841598281 1024 33839
SGTC_2388 9080168 200 µM 0.815248482396833 0.21826094976672 no 755 0.207465045629246 946 15943073
SGTC_1349 flufenamic acid 69 µM 0.814902711561998 0.218358838050366 no 756 0.207564000468736 964 3371 A non-steroidal anti-inflammatory.
SGTC_2686 alizarin 95.37 µM 0.814338554617754 0.218518606075194 no 757 0.207725514263761 986 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_319 1348-1596 45.5 µM 0.810214913775042 0.219688454546838 no 758 0.208908333712837 1043 5380505
SGTC_274 sirtinol 40.1 µM 0.806706054306948 0.220686719424868 no 759 0.209917927600708 1050 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_363 0455-0021 3.06 µM 0.806190877323163 0.220833504878058 no 760 0.210066399008322 1034 4597466
SGTC_2918 7977171 22.06 µM 0.805241118602939 0.22110425886828 no 761 0.210340276334799 1017 2236483
SGTC_2309 7664088 163.95 µM 0.802557334279769 0.221870368871899 no 762 0.211115318562995 1054 704922
SGTC_651 3253-0966 34.4 µM 0.80182730604167 0.222079023881617 no 763 0.21132643048214 1054 781462
SGTC_296 1222-0039 74.9 µM 0.800283799741074 0.222520553920854 no 764 0.211773193529097 1010 5984176
SGTC_213 1246-0773 967 nM 0.798980596135169 0.222893733218402 no 765 0.212150831670611 1034 6251622
SGTC_667 1498-1044 59 µM 0.797885358065055 0.223207636019996 no 766 0.212468510490954 1056 6739982
SGTC_1128 3448-9350 235 µM 0.796626351002325 0.22356878685489 no 767 0.212834034380291 943 619386
SGTC_526 4469-0568 170 µM 0.793901904458279 0.224351441057557 no 768 0.213626270453837 1025 2901964
SGTC_2214 7179297 48.276 µM 0.793522901008189 0.224460440810773 no 769 0.213736616034511 1059 769744
SGTC_3289 9119912 71.43 µM 0.793487219733421 0.22447070413868 no 770 0.213747006227311 1047 17014829
SGTC_3091 9116372 49.47 µM 0.79277609633138 0.224675306531357 no 771 0.213954142836108 1008 17169793
SGTC_1357 1503-1303 39.5 µM 0.792086830421457 0.224873721058364 no 772 0.214155024255349 1084 292895
SGTC_3139 9095020 49.47 µM 0.79165736520437 0.224997398649256 no 773 0.21428024416988 875 25236292
SGTC_2669 eugenol 100 µM 0.788166903847298 0.226004012040996 no 774 0.215299542630796 1027 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_844 0330-0132 15.3 µM 0.784542070383607 0.227052066436413 no 775 0.216361053152636 1105 2828079
SGTC_1370 2001-0092 44.6 µM 0.784228195041948 0.227142946493911 no 776 0.216453111938798 1136 790957
SGTC_292 k038-0015 474 µM 0.783404576459019 0.227381516039677 no 777 0.2166947847836 1083 46368540
SGTC_3329 9141233 27.5565 µM 0.781944857213518 0.22780468524372 no 778 0.217123490614482 1053 4909101 YNL103W MET4
SGTC_32 0928-0142 34.1 µM 0.781610332793511 0.22790172547735 no 779 0.217221806266583 1060 2244242
SGTC_1704 st028805 70.8 µM 0.781198916993566 0.228021102565832 no 780 0.217342755300787 1046 2876101
SGTC_1896 st058441 89 µM 0.780937464162566 0.228096984425095 no 781 0.217419638055486 974 688759
SGTC_1222 0366-0074 1.18 µM 0.780487539432428 0.228227600014104 no 782 0.217551979563125 1122 286520
SGTC_2483 5729050 27.16 µM 0.778815709952253 0.228713309390714 no 783 0.218044141053983 1112 2865180
SGTC_3025 9087895 49.47 µM 0.77819714568915 0.228893165173077 no 784 0.218226399628778 1113 17173641
SGTC_3141 9094609 49.47 µM 0.776406849354628 0.229414164703009 no 785 0.218754400878925 998 25236309 YDL196W YDL196W
SGTC_1056 3448-1962 115 µM 0.776383762458608 0.229420887628183 no 786 0.218761214555245 1023 715507
SGTC_2198 6589944 200 µM 0.774286261223663 0.230032142435352 no 787 0.219380763206136 1003 5290268
SGTC_263 alizarin 107.927 µM 0.773839048762298 0.230162587074429 no 788 0.219512988700174 1115 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.773743939828705 0.230190334146538 no 789 0.219541115074729 1011 688803
SGTC_758 0868-0029 16 µM 0.772652805582405 0.230508795393391 no 790 0.219863942086404 1111 762687
SGTC_2365 9042475 200 µM 0.772308825237275 0.230609241409436 no 791 0.219965769838331 1106 6464479
SGTC_2999 9069765 71.4286 µM 0.76879854026805 0.231635680099362 no 792 0.221006457794954 1105 2097066
SGTC_624 k048-0052 28 µM 0.7654225137186 0.232625257732959 no 793 0.222009995469725 1042 6835531
SGTC_1631 benzylvanillin 81.9 µM 0.764829465736432 0.23279933373836 no 794 0.222186549664298 1077 75506
SGTC_2103 5378138 10 µM 0.762979560368532 0.233342796942642 no 795 0.222737792879775 1153 244142
SGTC_837 0091-0265 12.5 µM 0.761629086237117 0.233739981900709 no 796 0.223140705015439 1074 759367
SGTC_1048 3161-0300 24.5 µM 0.76101438959866 0.233920893000841 no 797 0.223324236263319 1151 2165101
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.760813552652471 0.233980018044882 no 798 0.223384219179791 1066 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_451 chloral hydrate 100 µM 0.76055098865079 0.234057327602767 no 799 0.223462651616505 1141 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_968 1309-0633 340 µM 0.76046668402984 0.234082153323999 no 800 0.223487838196194 1093 3761976
SGTC_3058 9093861 49.47 µM 0.760388500249068 0.234105177905513 no 801 0.223511197576375 1087 17217477
SGTC_1977 st070720 65.3 µM 0.759720949239386 0.234301818111305 no 802 0.223710701853038 1051 682188
SGTC_3080 9117754 49.47 µM 0.755748999289723 0.235473721906677 no 803 0.224899849974643 1140 9550191
SGTC_2770 toltrazuril 17.5 µM 0.755263684095378 0.235617133121652 no 804 0.225045392033844 1115 68591 Kills coccidiodes.
SGTC_412 gemfibrozil 100 µM 0.754434708630108 0.235862207747307 no 805 0.225294118399473 1089 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1228 0124-0032 52.5 µM 0.75355467185854 0.236122531608879 no 806 0.225558335508772 1141 X1228
SGTC_3081 9117243 49.47 µM 0.752016479235503 0.236577924553983 no 807 0.226020574358145 1111 45595589
SGTC_2152 5568786 200 µM 0.748302855682339 0.237679358479518 no 808 0.227138751213331 1108 5399883
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.748171075300342 0.237718495209987 no 809 0.227178487665316 1100 6708760
SGTC_2414 st077232 92.9 µM 0.747705287339523 0.237856855340099 no 810 0.227318970626983 1043 729801
SGTC_2456 5770359 74.46 µM 0.747253167212802 0.237991197729664 no 811 0.227455378133503 1133 3118787
SGTC_1236 0330-0013 258 µM 0.746511521318678 0.238211659480109 no 812 0.227679237211142 1095 4617066
SGTC_228 caffeine 993.056 µM 0.745979793506551 0.238369789795654 no 813 0.227839810729828 1078 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2461 5755302 26.15 µM 0.744336295710896 0.238858912165754 no 814 0.228336524136319 1110 2788904
SGTC_1952 st077036 64.1 µM 0.744098290013265 0.23892979066013 no 815 0.228408506877845 1149 2937007
SGTC_395 anisomycin 6.25 µM 0.743978955933691 0.238965332876854 no 816 0.228444603225291 1046 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3164 9100705 49.47 µM 0.740825419666116 0.239905622450549 no 817 0.229399650176996 1109 17174235
SGTC_2350 9023895 38.85 µM 0.740595392278021 0.239974288570517 no 818 0.229469401325986 1113 2997209
SGTC_1902 st060212 70.5 µM 0.740043949429289 0.240138944954346 no 819 0.229636663595744 1174 688944
SGTC_3160 9100216 49.47 µM 0.739607512304158 0.240269305201018 no 820 0.229769091016683 1103 17191039
SGTC_2532 xanthone 78.9 µM 0.738804252620144 0.240509333145661 no 821 0.230012934568905 1022 7020 An insecticide.
SGTC_1250 0485-0349 40.2 µM 0.738627820868314 0.240562071501509 no 822 0.230066512909934 1127 6842794 YDL195W SEC31
SGTC_196 k015-0023 18.111 µM 0.737526498563791 0.240891417149687 no 823 0.230401117440536 1128 5211998
SGTC_640 3381-0960 37.1 µM 0.736934019692004 0.241068696800175 no 824 0.230581237287459 1170 1745025
SGTC_403 arphamenine a 50 µM 0.735955807035813 0.241361549673406 no 825 0.230878796422835 1102 5487158 An arginine aminopeptidase inhibitor.
SGTC_2427 5545055 42.75 µM 0.733557601537861 0.242080330644533 no 826 0.231609204711078 1165 5372858
SGTC_362 0310-0100 9.03 µM 0.732248057719993 0.242473311518052 no 827 0.232008588279627 1134 790235
SGTC_2368 9071271 200 µM 0.730947196778445 0.242864028629434 no 828 0.232405703107129 1128 27209959
SGTC_1265 0819-1001 68.8 µM 0.730180913856617 0.243094343132732 no 829 0.232639803718745 1139 3106768
SGTC_1136 pergolide 1.05886 µM 0.729039176771904 0.243437723371701 no 830 0.232988849179041 1100 47811 A dopamine receptor agonist.
SGTC_2796 7949634 45.45 µM 0.728739095725578 0.24352801695454 no 831 0.233080636518264 1117 2971588
SGTC_3344 9148862 3.898 µM 0.728104925862601 0.243718896463414 no 832 0.233274679363664 1165 4905352
SGTC_596 1155-0152 116 µM 0.725927505673901 0.244374894960252 no 833 0.233941606727374 1161 280313
SGTC_2737 bleomycin 30.5 nM 0.725418338180892 0.244528430670586 no 834 0.234097713137699 1190 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1886 st057356 49.9 µM 0.725139277040122 0.244612601542933 no 835 0.234183295369675 1129 24207747
SGTC_1257 0669-0121 16 µM 0.724906736840022 0.244682752610896 no 836 0.234254623829169 1204 4307855
SGTC_1325 1431-0015 227 µM 0.724584841588216 0.244779877546784 no 837 0.234353380546288 1103 1103340
SGTC_824 1304-0008 100 µM 0.723194640179783 0.245199579037486 no 838 0.234780155640819 1147 768245
SGTC_3355 9151058 44.0485 µM 0.722332014289422 0.24546020001004 no 839 0.235045187259987 1174 17015728
SGTC_282 k297-0036 65.7 µM 0.722004429483232 0.245559210597616 no 840 0.235145877106548 1134 5061378
SGTC_1797 st048695 56.8 µM 0.721778631478098 0.245627469209215 no 841 0.23521529457842 1127 592262 YIL048W NEO1
SGTC_1178 0988-0033 191 µM 0.721477577678139 0.245718493454378 no 842 0.235307865668478 1162 5392207
SGTC_1822 st052468 42 µM 0.720189082337346 0.246108277271801 no 843 0.235704292505815 1149 2873678
SGTC_430 0958-0115 16.4 µM 0.71986358955164 0.246206794814928 no 844 0.235804493969895 1083 6833180
SGTC_2524 avocatin b 10.57 µM 0.719643657667353 0.246273374001716 no 845 0.235872212287124 1114 6710748
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.719463016596902 0.246328066041138 no 846 0.235927840749856 1135 17037758
SGTC_1153 4055-0057 267 µM 0.718956989988287 0.246481308534067 no 847 0.236083710262736 1170 882706
SGTC_1725 st036284 20.55 µM 0.717504920169731 0.246921329334735 no 848 0.236531300806857 1177 707914
SGTC_2402 5553605 200 µM 0.716262327982472 0.247298205655798 no 849 0.23691469179318 1191 6758546
SGTC_1714 st033236 13.627 µM 0.715952510177494 0.247392220799167 no 850 0.237010336556481 1181 2916566
SGTC_3151 9099821 49.47 µM 0.715007600774944 0.247679074333974 no 851 0.237302173328585 1143 17174189
SGTC_1435 4092-0789 56.7 µM 0.713794461468124 0.248047616785583 no 852 0.237677142482871 1174 2248285
SGTC_831 k061-1017 217 µM 0.713687777634471 0.248080040508976 no 853 0.237710132925704 1221 1240153
SGTC_2744 captopril 92.04 µM 0.712692772378279 0.248382554832962 no 854 0.238017944948819 1130 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_812 4251-0442 148 µM 0.712517458412013 0.248435876411874 no 855 0.238072202213809 1166 5723007
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.712214679931874 0.248527980567696 no 856 0.238165923956315 1138 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_649 1123-0311 367 µM 0.712182456345483 0.248537783941144 no 857 0.238175899602564 1157 693629 YIL048W NEO1
SGTC_2852 9023854 51.95 µM 0.710993291165589 0.248899707410734 no 858 0.238544196572807 1211 19798528
SGTC_877 0771-0151 33.1 µM 0.710716609605212 0.248983955896253 no 859 0.238629932445997 1164 6166523
SGTC_566 0958-0068 16.5 µM 0.710068699772603 0.249181301341107 no 860 0.238830767538433 1154 6815365
SGTC_2435 5706476 10.6 µM 0.707608925077383 0.249931275549184 no 861 0.239594074415019 1196 5725375
SGTC_921 1561-0023 372 µM 0.707289066395728 0.250028886962308 no 862 0.239693429356146 1203 24050882
SGTC_585 0kpi-0023 191 µM 0.706624153110271 0.250231863549636 no 863 0.239900037560643 1138 64601
SGTC_3316 9136639 10.545 µM 0.706118034858843 0.250386423683125 no 864 0.240057368540882 1163 4903665
SGTC_3209 9113616 49.47 µM 0.705882267219103 0.250458440489433 no 865 0.240130678033315 1200 16649353
SGTC_606 k015-0008 38.6 µM 0.705759743911449 0.250495870389397 no 866 0.240168780198099 1229 1970475
SGTC_1698 5-fluorocytosine 1.055 µM 0.705541944802041 0.250562413609086 no 867 0.240236519262128 1196 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3106 9121286 49.47 µM 0.703932639833786 0.251054387706427 no 868 0.24073736179945 1204 15943471
SGTC_2346 9031566 143.75 µM 0.701888334193537 0.251680080290104 no 869 0.24137440232499 1152 4771086
SGTC_2640 pentamidine 10.38 µM 0.700224487626271 0.252189934540442 no 870 0.241893560586657 1211 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3214 9129694 49.47 µM 0.699164786406663 0.252514943615796 no 871 0.242224527175244 1154 17158655
SGTC_1397 3532-0190 20.1 µM 0.698411327021586 0.25274616286525 no 872 0.242459997335059 1119 5322280
SGTC_2458 5808907 16.39 µM 0.698140031509553 0.252829444468841 no 873 0.242544812612085 1259 2731747
SGTC_3322 9139058 2.11 µM 0.696979920535559 0.253185735278205 no 874 0.242907679992641 1211 4908926 YPR165W RHO1
SGTC_1705 st027868 56.3335 µM 0.696252383552437 0.253409309532151 no 875 0.24313539371981 1207 292948
SGTC_2014 4013930 200 µM 0.696126915680919 0.253447876665358 no 876 0.243174675907406 1186 64556
SGTC_3021 9087658 49.47 µM 0.695945650408786 0.253503600614482 no 877 0.243231433518449 1183 25237042
SGTC_225 nsc-122657 1.016 µM 0.695837663333335 0.253536800690947 no 878 0.243265249733264 1124 275685
SGTC_1703 st026983 48.3 µM 0.694687275484386 0.253890623319476 no 879 0.24362565203491 1204 1104023
SGTC_3221 9128209 49.47 µM 0.69240382363941 0.25459370731925 no 880 0.244341882635902 1214 16460723
SGTC_1272 0839-0021 27 µM 0.692318190826516 0.254620093832359 no 881 0.244368764399468 1190 5027250
SGTC_943 3253-1379 105 µM 0.692310814213907 0.254622366895881 no 882 0.244371080132585 1195 668464
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.691931391818789 0.254739298198474 no 883 0.244490207797984 1232 66535 A nucleotide analog.
SGTC_893 0958-0369 48.9 µM 0.691511192038434 0.254868829176677 no 884 0.244622174885672 1215 6819948
SGTC_9 0092-0002 10.449 µM 0.691382650456467 0.254908460348646 no 885 0.244662552054252 1184 759368
SGTC_3309 9129340 25.759 µM 0.691257753044077 0.25494697106101 no 886 0.244701787962539 1219 17158987
SGTC_2598 perillyl alcohol 100 µM 0.689840212163359 0.25538426711854 no 887 0.245147338798146 1199 10819 An apoptosis inducer.
SGTC_428 3448-4153 16.5 µM 0.68856032812717 0.255779434013258 no 888 0.245549996844227 1171 3834874
SGTC_1923 st058458 19.1 µM 0.688131905231922 0.255911781756324 no 889 0.245684860195818 1252 3534982
SGTC_989 1501-0895 10.3 µM 0.687193615369962 0.256201761606737 no 890 0.245980363593262 1201 2830112
SGTC_1448 4255-0083 152 µM 0.686503067916005 0.256415285694351 no 891 0.246197965184718 1252 5399660
SGTC_3084 9116877 49.47 µM 0.685244794112303 0.256804594660101 no 892 0.246594730900856 1138 27241325
SGTC_3065 9113888 49.47 µM 0.683450451076834 0.257360294754156 no 893 0.247161124815369 1265 16648368
SGTC_3042 9091578 49.47 µM 0.683291146190417 0.257409660956525 no 894 0.247211443855292 1184 25236497
SGTC_2840 9008771 71.43 µM 0.682306030266337 0.257715042901161 no 895 0.24752273038731 1187 2992978
SGTC_34 0469-0683 81.75 µM 0.681398447329026 0.257996556298483 no 896 0.24780970253469 1212 3690923
SGTC_1753 st043925 64 µM 0.678683611566183 0.258839593211311 no 897 0.248669176160528 1233 670181
SGTC_3288 9119690 36.221 µM 0.678208667915372 0.258987223639684 no 898 0.248819698731561 1197 17595618 YKL019W RAM2
SGTC_1912 st060209 90.8 µM 0.6777664889463 0.259124708704039 no 899 0.248959880873611 1202 688787
SGTC_3146 9095609 49.47 µM 0.677486515022939 0.25921177946153 no 900 0.249048661556821 1245 17173999
SGTC_976 1348-1067 47.6 µM 0.677391804678235 0.259241237418281 no 901 0.249078698341597 1268 5310671 YGL099W LSG1
SGTC_3312 9133330 71.43 µM 0.677192835066473 0.259303128988122 no 902 0.24914180656794 1247 17617324
SGTC_2549 cedrol 20.94 µM 0.677174634928493 0.259308790711708 no 903 0.249147579624865 1182 6708665 A sedative which affects the nervous system.
SGTC_587 k089-0003 57 µM 0.676421365431044 0.259543174827767 no 904 0.249386577999105 1168 9659696
SGTC_1413 3910-0535 34.4 µM 0.674981843242121 0.259991394493654 no 905 0.24984365031328 1239 2876951
SGTC_2474 5321570 43.32 µM 0.674516843032475 0.260136265452145 no 906 0.249991390609972 1232 2841384
SGTC_1863 st057641 20.1 µM 0.674381114470054 0.260178559571809 no 907 0.250034523153424 1246 3921635
SGTC_1279 0874-0590 65.2 µM 0.67424280534503 0.26022166146129 no 908 0.250078479823299 1242 3523074
SGTC_2408 sulbentine 18.36 µM 0.673504856938772 0.260451693792405 no 909 0.25031307993121 1207 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_257 daunorubicin 18.5 µM 0.673083104284694 0.260583209002066 no 910 0.250447211085549 1271 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2395 5646831 180.19 µM 0.672687537969924 0.260706589582444 no 911 0.250573048735281 1247 6808628
SGTC_490 phenamil 164 µM 0.672368078670842 0.260806253660038 no 912 0.250674699647512 1170 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1932 st074806 40.9 µM 0.671367552199995 0.261118522074434 no 913 0.250993205189296 1334 17251235
SGTC_454 lyso-paf C-16 6.67 µM 0.670992979473753 0.261235477178571 no 914 0.251112500970867 1174 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2318 6029776 164 µM 0.668849090236371 0.26190539417288 no 915 0.251795874171361 1254 818325
SGTC_2828 7998861 71.43 µM 0.663875119325137 0.263463033641729 no 916 0.253385120924058 1169 2988188
SGTC_2623 humulene 100 µM 0.661807022923802 0.264112063801601 no 917 0.254047452350198 1196 6187145 An anti-inflammatory.
SGTC_1197 1601-0112 267 µM 0.661651963504311 0.264160758863666 no 918 0.254097148472112 1246 7350313
SGTC_1990 st072050 59.8 µM 0.657710212644549 0.265400165278164 no 919 0.25536217935775 1257 17233948
SGTC_219 mitoxanthrone 164.414 µM 0.65694178531825 0.265642125480896 no 920 0.25560917451032 1249 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1644 st010134 20.9 µM 0.656569234066832 0.265759473606119 no 921 0.255728968340075 1247 3818134
SGTC_2763 lisinopril 49.32 µM 0.656511569193037 0.265777639535381 no 922 0.255747513095679 1223 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2084 5306078 60.6385 µM 0.655720123760715 0.266027028938846 no 923 0.256002109199984 1209 679340
SGTC_2705 st078069 42.8 µM 0.655073664994627 0.266230820050105 no 924 0.256210163338725 1240 1530061
SGTC_2470 5664817 21.68 µM 0.65505914902665 0.266235397003421 no 925 0.256214836121377 1288 2859561
SGTC_1791 st048313 56.1 µM 0.654290750903784 0.266477733408254 no 926 0.256462251791126 1210 1204976
SGTC_379 3970-0972 5.9 µM 0.653505534481766 0.266725489161379 no 927 0.256715211301584 1265 2898042 YBL034C STU1
SGTC_555 4296-0685 37 µM 0.653233997484187 0.266811193075706 no 928 0.256802717868463 1234 2908540 YHR072W ERG7
SGTC_2343 7990716 14.84 µM 0.651432563814138 0.267380123071839 no 929 0.257383647797097 1242 6456862
SGTC_1381 2324-0066 62.1 µM 0.648203562537613 0.268401437688088 no 930 0.258426649016657 1280 10885928
SGTC_441 propafenone 146 µM 0.647516442952618 0.268619022552688 no 931 0.258648878045 1232 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2413 inermin 26.06 µM 0.646557917041089 0.26892269957288 no 932 0.258959050820929 1386 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2642 cholecalciferol 100 µM 0.643197303422331 0.269988757831507 no 933 0.260048041416159 1270 9821465 A vitamin D precursor, similar to steriods.
SGTC_1046 2001-0062 216 µM 0.641031741521694 0.270676838926609 no 934 0.260751030221203 1243 739778
SGTC_1189 1431-2119 7.28 µM 0.640601697080433 0.270813584487973 no 935 0.260890748343877 1297 3107275
SGTC_1008 4106-0037 6 µM 0.640237505106476 0.270929417238146 no 936 0.261009101613274 1261 2905394
SGTC_2953 9074162 66.49 µM 0.639546222341136 0.271149350529798 no 937 0.261233827102229 1265 16451992
SGTC_1882 5615643 20 µM 0.637052285178225 0.27194354189189 no 938 0.262045393557236 1223 2253075
SGTC_2843 9000894 45.46 µM 0.63623578281627 0.272203807299061 no 939 0.262311376835318 1159 2242070
SGTC_2658 polymyxin b sulfate 77.05 µM 0.633705648178757 0.273011089422732 no 940 0.263136469086378 1262 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1793 st048256 72.231 µM 0.633609144479344 0.27304190403842 no 941 0.263167965760666 1221 672022
SGTC_2506 ethyl hematommate 54.16 µM 0.633287618931427 0.273144582865278 no 942 0.263272918489095 1250 3940691 An allergen.
SGTC_3233 9132340 49.47 µM 0.633224417916684 0.273164768289195 no 943 0.263293551148561 1249 17682950
SGTC_3062 9077494 49.47 µM 0.632224249317011 0.273484304998038 no 944 0.263620176978591 1291 16459633
SGTC_778 3456-2434 196 µM 0.632094416687928 0.273525797859773 no 945 0.26366259167466 1332 5539063
SGTC_2270 7924575 90.91 µM 0.630109717624689 0.274160470106971 no 946 0.264311401102999 1302 1262135
SGTC_2742 clothiapine 36.27 µM 0.630067040497673 0.274174125495176 no 947 0.26432536142124 1263 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3186 9110464 49.47 µM 0.629309802948413 0.274416474427706 no 948 0.264573127409724 1312 17018021
SGTC_2746 daunorubicin 9.88 µM 0.627185491789971 0.275096910173076 no 949 0.265268826112183 1211 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1959 st077091 55.8 µM 0.62211129585071 0.276725575484845 no 950 0.266934343937691 1315 821356 YKL052C ASK1
SGTC_674 0498-0004 451 µM 0.620618615892329 0.277205578856978 no 951 0.267425294099273 1274 4231473
SGTC_3317 9138495 8.753 µM 0.619973330524394 0.277413210283428 no 952 0.267637672705176 1298 17020139
SGTC_2938 9059746 27.26 µM 0.617965021654134 0.278059903572656 no 953 0.268299198006666 1299 6471769
SGTC_1085 doxorubicin 7.67 µM 0.617944770723614 0.278066428295742 no 954 0.268305872732194 1329 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2595 hexamethylquercetagetin 100 µM 0.617605313578627 0.278175810381691 no 955 0.268417770556476 1290 386331
SGTC_2256 7954252 200 µM 0.616958950581712 0.278384143662747 no 956 0.268630900938672 1268 2972920
SGTC_2188 6126565 140.678 µM 0.616118022271323 0.278655302267206 no 957 0.268908314115782 1297 874518
SGTC_2745 rifampicin 24.3 µM 0.615698654024349 0.278790576235202 no 958 0.269046712909433 1273 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2624 nerol 100 µM 0.614835917798925 0.279068966139634 no 959 0.269331543198778 1296 637566 A natural product oil.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.614564869642779 0.279156456540925 no 960 0.269421060299892 1298 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2347 9049783 174.81 µM 0.614287566369269 0.279245979800075 no 961 0.269512658665939 1333 6467988 YPL169C MEX67
SGTC_785 1270-0111 65.3 µM 0.61390295283587 0.279370169680483 no 962 0.269639729412361 1305 6741994
SGTC_1561 5-methoxyflavone 52.9 µM 0.612306211068016 0.279886036728442 no 963 0.270167590534657 1281 94525
SGTC_220 paclitaxel 373.376 µM 0.607683092118142 0.281382249860511 no 964 0.271698839538593 1327 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2525 harmine 47.85 µM 0.607627675529354 0.281400208116145 no 965 0.271717220545892 1326 5280953 A monoamine oxidase inhibitor
SGTC_209 4077-0173 175.592 µM 0.603917192468242 0.282603880902805 no 966 0.272949348915814 1294 15993494
SGTC_737 1950-0117 57.9 µM 0.603745205808324 0.28265973296909 no 967 0.273006527093847 1290 5393513
SGTC_2245 6637752 200 µM 0.601452281509314 0.283404858473486 no 968 0.27376939277298 1309 681890
SGTC_2211 7117706 200 µM 0.600973010611876 0.283560724763967 no 969 0.273928981352128 1319 822771
SGTC_1241 0364-0022 50.8 µM 0.600933318606734 0.283573635057933 no 970 0.273942200136802 1381 4563895
SGTC_433 pimozide 108 µM 0.59830963365695 0.284427643573205 no 971 0.274816674872257 1286 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1421 4029-0249 71.4 µM 0.597071386459189 0.2848311189645 no 972 0.275229860337781 1436 2894095
SGTC_67 0335-0847 266 µM 0.597067573546459 0.284832361800783 no 973 0.275231133124646 1540 4552207 YOR254C SEC63
SGTC_258 haloperidol 50.781 µM 0.596668883403304 0.284962330948212 no 974 0.275364235710494 1292 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2724 maprotiline 69.64 µM 0.596238226799573 0.285102752622372 no 975 0.275508045866625 1344 4011 A tricyclic antidepressant.
SGTC_1908 st060353 56.5 µM 0.595265069340956 0.285420185798853 no 976 0.275833150579961 1419 4227716
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.594611216729732 0.285633559757072 no 977 0.276051690286043 1459 6728940
SGTC_2546 rhodinyl acetate 100 µM 0.593950736144801 0.28584917367667 no 978 0.276272531564086 1351 6708682
SGTC_3205 9113483 49.47 µM 0.592302964450039 0.28638742595306 no 979 0.276823865582405 1395 17018033
SGTC_2191 5911152 200 µM 0.592103950596649 0.286452467297959 no 980 0.276890490819126 1343 2875902
SGTC_3252 9135871 49.47 µM 0.591908846926959 0.286516237527347 no 981 0.276955814638256 1373 17682838
SGTC_1329 1447-1697 50.6 µM 0.591105015506108 0.286779043293157 no 982 0.277225029767269 1336 2840515
SGTC_1348 1493-0373 93.8 µM 0.59058569027466 0.286948892943847 no 983 0.277399027571723 1370 3010129
SGTC_882 0843-0131 351 µM 0.589814600775053 0.287201172075421 no 984 0.277657476419671 1353 5425421
SGTC_2914 7968218 45.32 µM 0.589209062265172 0.287399361072944 no 985 0.277860519366658 1374 2977111
SGTC_2302 7771753 200 µM 0.585299617393251 0.288680452614506 no 986 0.279173136042214 1306 2203047
SGTC_1124 fisetin 1.16336 µM 0.585188937352523 0.288716760628466 no 987 0.279210341280194 1370 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1715 st032160 10.2275 µM 0.582714087643229 0.289529183312671 no 988 0.280042894014019 1344 5289825
SGTC_2730 imipramine 71.33 µM 0.581059565696069 0.29007291379639 no 989 0.280600154419071 1391 3696 A tricyclic antidepressant.
SGTC_281 1672-3440 14.9 µM 0.577944059301474 0.291098069033071 no 990 0.281650943858076 1380 6833000
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.577570203936376 0.291221199506328 no 991 0.28177716416018 1398 5393153
SGTC_3293 9120939 62.045 µM 0.577049876256495 0.291392611568774 no 992 0.281952881518372 1399 934087
SGTC_868 0527-0199 213 µM 0.573485308963655 0.292568154384227 no 993 0.283158071699365 1383 2849450
SGTC_2838 9002687 71.43 µM 0.573181345246997 0.292668499112687 no 994 0.283260956945651 1358 6457060
SGTC_1317 1273-0028 910 nM 0.573092712154753 0.29269776174516 no 995 0.283290960736318 1367 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3133 9127736 49.47 µM 0.571972858257647 0.293067603773553 no 996 0.283670181317194 1411 27243420
SGTC_945 3381-0768 11.3 µM 0.571918520565027 0.293085554808149 no 997 0.283688588089777 1373 1126236 YIL048W NEO1
SGTC_856 0433-0016 11.3 µM 0.570960380020146 0.293402170473045 no 998 0.284013250008927 1380 3911780
SGTC_1604 st002052 72.4 µM 0.570084299341911 0.293691808230499 no 999 0.284310261776753 1403 6254834 YHR062C RPP1
SGTC_1167 k781-0610 148 µM 0.569378405062821 0.29392527752521 no 1000 0.284549684337137 1410 4525169
SGTC_2075 5212009 200 µM 0.567692083488824 0.29448336301173 no 1001 0.285122033984875 1389 780898
SGTC_146 3448-8650 53.125 µM 0.566254765759626 0.29495942679286 no 1002 0.285610302721373 1436 2891488 YIL048W NEO1
SGTC_476 mead acid 10 µM 0.565826041219818 0.295101496194428 no 1003 0.28575602100693 1415 5312531 An omega 9 fatty acid.
SGTC_156 3474-0145 5.642 µM 0.565816648381817 0.295104609116551 no 1004 0.285759213914781 1343 2265471
SGTC_208 k072-0098 12.366 µM 0.565273411945983 0.295284671237248 no 1005 0.285943905165921 1377 5948901
SGTC_1874 staurosporine 7.6 µM 0.564839279272048 0.295428605970782 no 1006 0.286091543753622 1446 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3156 9099931 49.47 µM 0.564487435365558 0.295545281905679 no 1007 0.286211224378986 1445 18111053
SGTC_1512 0259-0544 12.2 µM 0.563620698452906 0.295832793285998 no 1008 0.286506148597035 1378 18476
SGTC_1064 honokiol 6.76 µM 0.563422387990591 0.295898594296265 no 1009 0.286573647881345 1374 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2777 climbazole 1.536 µM 0.563295420291657 0.295940726731295 no 1010 0.286616868062992 1401 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1684 st024538 14.6195 µM 0.562889612585018 0.296075406746676 no 1011 0.286755026937776 1395 6732859
SGTC_182 3448-4371 550.524 µM 0.562801180676478 0.296104759381488 no 1012 0.286785138127587 1451 3491403
SGTC_3083 9117465 49.47 µM 0.561859920135414 0.296417268656354 no 1013 0.28710573150902 1358 16420915
SGTC_201 4262-0159 12.803 µM 0.561108326237331 0.296666914937568 no 1014 0.287361846208587 1385 1341029
SGTC_2066 5222451 176 µM 0.560804764668963 0.296767771968434 no 1015 0.287465319113725 1361 2281147
SGTC_1299 1079-1439 3.74 µM 0.559170890542667 0.297310889058245 no 1016 0.28802254875943 1351 323161
SGTC_859 0439-0102 54.6 µM 0.557578358743712 0.297840700150763 no 1017 0.288566168849226 1428 610143
SGTC_2966 9084041 48.03 µM 0.556337686489179 0.298253751056505 no 1018 0.288990014329512 1292 17741380
SGTC_1460 k062-0059 9.15 µM 0.556034846248484 0.298354613758387 no 1019 0.289093516780217 1361 1373085
SGTC_187 1488-2104 32.728 µM 0.555019245293122 0.298692978844362 no 1020 0.289440748410022 1462 2852859
SGTC_2846 9008642 19.48 µM 0.553873387479732 0.299074950580418 no 1021 0.289832749604734 1402 2992898
SGTC_2625 euphol 100 µM 0.551930224081534 0.299723210536132 no 1022 0.290498079962446 1480 6708538 A triterpene alcohol.
SGTC_2793 7325131 81.82 µM 0.55142318717351 0.299892468076459 no 1023 0.290671804627888 1444 4176441
SGTC_2583 asiatic acid 100 µM 0.550578121610768 0.30017466142958 no 1024 0.290961455062755 1402 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3124 9127567 49.47 µM 0.549330100331043 0.300591633526321 no 1025 0.291389467074188 1476 17592030
SGTC_2855 9016525 58.44 µM 0.549286823258641 0.300606097370402 no 1026 0.2914043143227 1377 43811474
SGTC_404 fumagillin 50 µM 0.549123943188129 0.30066053713955 no 1027 0.291460197442089 1417 12015870 A methionine aminopeptidase binder.
SGTC_2958 9077254 16.72 µM 0.548933497393158 0.300724195905172 no 1028 0.291525544525652 1425 16457351
SGTC_2666 tannic acid 100 µM 0.548695411595196 0.3008037874606 no 1029 0.291607247786764 1444 16134267 A thiamine antagonist.
SGTC_3 0833-0587 95.581 µM 0.547519766067315 0.301196942402774 no 1030 0.292010847316455 1348 5382644
SGTC_818 4072-2707 53.5 µM 0.546573962065006 0.301513402531156 no 1031 0.292335730819792 1355 882871
SGTC_1920 st075728 45.7 µM 0.546455584942157 0.301553021311425 no 1032 0.292376405173026 1513 3400306
SGTC_2009 4012297 12.05 µM 0.546451998905951 0.30155422153241 no 1033 0.292377637375337 1412 45595307
SGTC_2327 6189656 200 µM 0.546111107895426 0.301668325156526 no 1034 0.292494782377779 1517 5349088
SGTC_1212 0520-0165 585 µM 0.542514734747616 0.302873290288695 no 1035 0.293731979812145 1628 5403258
SGTC_2287 7945887 168.79 µM 0.542358963881803 0.302925529985968 no 1036 0.293785621617619 1450 1245853
SGTC_20 0481-0013 4.944 µM 0.542207276547103 0.302976404095814 no 1037 0.293837861559301 1393 182045
SGTC_1052 3253-3998 198 µM 0.540008127213185 0.303714401480909 no 1038 0.29459571381244 1387 5450317
SGTC_3144 9087057 49.47 µM 0.539939730674144 0.30373736706361 no 1039 0.294619298502358 1412 17249618
SGTC_2866 9034245 58.44 µM 0.536489346660829 0.304896910386647 no 1040 0.295810198358125 1457 6462273
SGTC_619 1652-1634 108 µM 0.535712013765387 0.305158413742817 no 1041 0.296078799671738 1420 5400454
SGTC_3225 9130819 49.47 µM 0.533263337613179 0.305982825329635 no 1042 0.296925651347424 1477 4547121
SGTC_2243 6634756 200 µM 0.531738676214497 0.306496640232835 no 1043 0.29745350040496 1529 885676
SGTC_1081 sertraline 6 µM 0.529710627037404 0.307180687964897 no 1044 0.298156289352065 1483 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.527206728528048 0.30802616284442 no 1045 0.299025018323852 1367 88881 An O-methylated flavonoid and antioxidant.
SGTC_1262 0737-0114 49.6 µM 0.525719106618563 0.308528961624786 no 1046 0.299541693240266 1461 765919
SGTC_2000 st075254 36.4 µM 0.525226914184589 0.308695396047302 no 1047 0.299712728594176 1415 17234175
SGTC_2977 9011197 71.43 µM 0.524654076632952 0.308889150033679 no 1048 0.299911843558195 1503 2704722
SGTC_1960 st011366 51.8 µM 0.524194181670799 0.309044741328581 no 1049 0.300071743658486 1442 3972846
SGTC_2722 naftopidil 47.16 µM 0.521363079112635 0.310003311528404 no 1050 0.30105693313754 1481 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3182 9108849 49.47 µM 0.521011718712226 0.310122367369358 no 1051 0.301179303938716 1449 17133045
SGTC_3012 9080433 71.4286 µM 0.520228120041724 0.310387955604111 no 1052 0.301452294136048 1527 17688859
SGTC_3199 9111318 49.47 µM 0.519476059059732 0.310642947657397 no 1053 0.30171440190887 1500 8548020
SGTC_2179 6298986 200 µM 0.517749433932847 0.311228717301994 no 1054 0.302316551421354 1541 738374
SGTC_1776 st049249 45.9 µM 0.517673769075359 0.31125439808548 no 1055 0.302342951385027 1422 1822314
SGTC_2891 9063876 19.48 µM 0.516602391708299 0.311618123969142 no 1056 0.302716872889106 1462 6472478
SGTC_524 r073-0010 27.8 µM 0.514105785328913 0.312466419223144 no 1057 0.303589016409722 1404 2772106
SGTC_2144 5628481 200 µM 0.512492630230114 0.313015065333978 no 1058 0.304153138430825 1463 2818399
SGTC_890 0929-0006 47.2 µM 0.512424728702478 0.313038168246239 no 1059 0.304176893906299 1415 1378169
SGTC_2237 6667747 47.222 µM 0.511973905312489 0.313191575650345 no 1060 0.304334636264331 1481 729940 YDL015C TSC13
SGTC_1628 st004252 77.7 µM 0.508405472081009 0.314406990998077 no 1061 0.305584508011553 1571 692968
SGTC_2196 6573537 42.6665 µM 0.508329287060032 0.314432961774924 no 1062 0.305611217199887 1542 2903087
SGTC_56 0957-0365 83.25 µM 0.507642830661044 0.3146670098894 no 1063 0.305851923915655 1426 6752360
SGTC_2749 bexarotene 57.39 µM 0.506924004642357 0.314912174299131 no 1064 0.306104070996032 1438 82146 An retinoic acid receptor inhibitor.
SGTC_1739 st037196 92.5 µM 0.504023619589484 0.3159022139101 no 1065 0.307122389583547 1555 612214
SGTC_1360 1598-0022 39.8 µM 0.5039461150413 0.315928688071569 no 1066 0.307149621718669 1556 761525
SGTC_700 3453-2283 142 µM 0.502817949245055 0.316314156078577 no 1067 0.307546136411141 1543 565664
SGTC_2829 7992743 58.44 µM 0.498358391183469 0.317839834827371 no 1068 0.309115729268971 1561 16462845
SGTC_1016 4226-1401 38 µM 0.497875508362689 0.318005222281498 no 1069 0.309285895404695 1472 2901613
SGTC_2314 7727897 200 µM 0.497406491743361 0.318165895314466 no 1070 0.309451214312145 1447 900724
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.497203808387132 0.318235340012155 no 1071 0.309522668048699 1498 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2545 solidagenone 89.61 µM 0.496833858763733 0.318362111045273 no 1072 0.309653108191467 1411 6708572 An anti ulcer agent
SGTC_1744 st037937 38.9 µM 0.494689224596988 0.319097433863452 no 1073 0.310409754437886 1548 1016152
SGTC_819 1013-0258 27.7 µM 0.494178645428826 0.319272599358751 no 1074 0.310590009832779 1481 5753198
SGTC_948 3448-0295 75.3 µM 0.49359770375226 0.319471953344634 no 1075 0.310795161400135 1485 678569
SGTC_2463 5473429 200 µM 0.492915385732448 0.319706161936755 no 1076 0.311036187758066 1496 5399405
SGTC_2712 st079126 47.7 µM 0.492401081711939 0.319882746539162 no 1077 0.311217917374965 1444 3152970
SGTC_1975 st070967 30.8 µM 0.491897839594363 0.320055572591523 no 1078 0.311395782815852 1573 261391
SGTC_2382 9035899 200 µM 0.49166713097601 0.320134816816412 no 1079 0.311477338985467 1493 6462679
SGTC_2568 diosmetin 100 µM 0.490941781181236 0.320384014751831 no 1080 0.311733812507139 1499 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_534 k292-0788 63.4 µM 0.490287170187518 0.320608979533 no 1081 0.311965352202217 1558 4146317
SGTC_2389 9091542 195.52 µM 0.490276140846455 0.320612770460854 no 1082 0.311969253980842 1484 3626624 YOL127W RPL25
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.489150611146702 0.320999727971113 no 1083 0.312367536212764 1599 165506
SGTC_993 3909-8757 62.7 µM 0.487874570171184 0.321438666552559 no 1084 0.312819343943741 1510 4288324 YLR208W SEC13
SGTC_1881 5652484 16 µM 0.486672646958024 0.32185233793775 no 1085 0.313245166134514 1576 2255129
SGTC_2553 4-methylesculetin 85.09 µM 0.486654195454393 0.321858690198608 no 1086 0.31325170515047 1462 5319502
SGTC_1093 fluphenazine 7.97 µM 0.485916352648133 0.322112748459257 no 1087 0.313513236868253 1538 6602611 An atypical antipsychotic.
SGTC_2425 5628681 7.85 µM 0.484284454440314 0.322674948174286 no 1088 0.314092003499859 1577 5714958
SGTC_1834 st055981 52.8 µM 0.482982759427085 0.323123681596096 no 1089 0.314553988872822 1585 471719 YDL150W RPC53
SGTC_1354 1498-1681 81 µM 0.482129404729354 0.323417998424891 no 1090 0.314857011215875 1518 5754243
SGTC_484 loperamide 105 µM 0.479428839566084 0.324350134508585 no 1091 0.315816790456975 1513 3955 An opioid-receptor agonist.
SGTC_919 tnp00227 403.569 nM 0.479213119426296 0.324424640787302 no 1092 0.315893510967357 1536 1269246 A methoxyflavone. YNL221C POP1
SGTC_97 0535-0701 19.132 µM 0.478444333959796 0.324690224110194 no 1093 0.316166992726758 1442 2832013 YGL099W LSG1
SGTC_3195 9113082 49.47 µM 0.478432384553779 0.324694352835706 no 1094 0.316171244309852 1562 17018038
SGTC_3093 9117344 49.47 µM 0.475952917037766 0.325551516843377 no 1095 0.317053960700663 1510 24824913
SGTC_256 clotrimazole 625 nM 0.474473059287062 0.326063551227535 no 1096 0.31758130252001 1524 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2224 6650123 117.647 µM 0.473965993291086 0.326239072823904 no 1097 0.317762078854057 1519 2908370
SGTC_632 0781-2353 4.65 µM 0.470863574226597 0.327313816527878 no 1098 0.318869080833527 1548 6811515 YHR007C ERG11
SGTC_904 1141-0088 396 µM 0.468402132992609 0.328167532088524 no 1099 0.31974852148872 1435 1378119
SGTC_1522 st012842 45.6 µM 0.467269698409958 0.328560602770375 no 1100 0.320153466504778 1443 3491067 YOR116C RPO31
SGTC_2151 5563267 85.4165 µM 0.467267828410427 0.328561252008642 no 1101 0.320154135371538 1533 5310824
SGTC_1244 0416-0015 52.5 µM 0.467114169412076 0.328614602080171 no 1102 0.320209098556793 1520 96201
SGTC_2306 7482397 179.52 µM 0.4668343173679 0.328711775078836 no 1103 0.320309210605132 1642 891448
SGTC_166 k072-0058 166.424 µM 0.466304259434293 0.328895858785363 no 1104 0.320498865165952 1556 5846229
SGTC_549 1661-1316 519 µM 0.465657776140441 0.329120432019662 no 1105 0.32073024013929 1633 2857282
SGTC_74 000s-0487 160.283 µM 0.462692245439298 0.330151377686149 no 1106 0.321792488720119 1423 677548
SGTC_1620 st003704 16.5 µM 0.462331080657892 0.330277022393551 no 1107 0.321921957174464 1551 2834414
SGTC_1490 4089-0339 670 nM 0.461478887347256 0.330573565620138 no 1108 0.322227532626628 1595 742542
SGTC_3161 9100388 49.47 µM 0.460568629738546 0.33089043137463 no 1109 0.322554061256666 1598 25236368
SGTC_655 k060-0012 42 µM 0.458583766922173 0.331581793208355 no 1110 0.323266547979158 1510 5994525
SGTC_2164 5685496 200 µM 0.457944898620514 0.331804444277214 no 1111 0.323496014395888 1595 759046
SGTC_848 0368-0089 85.6 µM 0.457458429385054 0.331974022822728 no 1112 0.323670787697633 1572 762535
SGTC_1406 3909-7906 11.9 µM 0.456567844536821 0.332284561400791 no 1113 0.323990847966007 1581 X1406
SGTC_1383 3049-0032 20.7 µM 0.455377288770587 0.332699876911998 no 1114 0.324418915698596 1646 712864
SGTC_597 k018-0003 82.8 µM 0.450556041953024 0.334383824527549 no 1115 0.326154777260285 1646 6786234
SGTC_3008 9078912 71.4286 µM 0.449783846047478 0.334653845321429 no 1116 0.326433153405428 1532 16648731
SGTC_1291 0993-0025 5.79 µM 0.448658549817969 0.335047491048724 no 1117 0.32683899510354 1640 4353356
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.446874014441767 0.335672120179304 no 1118 0.327483013573586 1704 551469
SGTC_779 1360-0071 233 µM 0.446045128412227 0.335962404314161 no 1119 0.32778232393577 1718 7566
SGTC_3236 9132701 49.47 µM 0.444732995523318 0.336422126358124 no 1120 0.328256360734286 1517 24282524
SGTC_692 k241-0027 77.8 µM 0.44355836755977 0.3368338794225 no 1121 0.328680955608475 1650 3600480
SGTC_1100 amiodarone 5.07 µM 0.443450908623973 0.336871557759068 no 1122 0.328719810037224 1665 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_576 1073-0113 22.7 µM 0.4423902078356 0.337243559155722 no 1123 0.329103431851419 1641 5439563
SGTC_2194 5927483 104.545 µM 0.442266349654483 0.33728700819717 no 1124 0.329148239171629 1581 760979
SGTC_2885 9057732 51.95 µM 0.44225791301269 0.337289967822235 no 1125 0.329151291326658 1573 6471414
SGTC_2098 5376439 882.5 nM 0.441737111667372 0.337472687578482 no 1126 0.329339725593925 1670 2844116
SGTC_2676 harmalol 100 µM 0.440408391637138 0.337939033892736 no 1127 0.32982067409402 1625 5459187 A monoamine oxidase inhibitor
SGTC_323 4013-0906 34.3 µM 0.439703677265437 0.338186471422701 no 1128 0.330075869453533 1657 2910086
SGTC_3188 9110789 49.47 µM 0.438829637943264 0.338493459017871 no 1129 0.330392491635656 1633 849217
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.438313541740472 0.338674777183765 no 1130 0.330579505382324 1546 6708630 An antioxidant.
SGTC_2325 6158266 200 µM 0.438026812010983 0.338775529039031 no 1131 0.330683423678329 1554 3623240
SGTC_270 tamoxifen 5.46 µM 0.437098535166072 0.339101788528233 no 1132 0.331019944795906 1696 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_982 1491-0518 27.5 µM 0.436391004575616 0.339350543873157 no 1133 0.331276532188613 1583 3091256
SGTC_1562 morin hydrate 59.1 µM 0.435763630231877 0.339571176267121 no 1134 0.33150411704002 1602 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2261 9010538 184.68 µM 0.435027254580602 0.339830211936165 no 1135 0.33177132232942 1495 6457250
SGTC_2010 4012422 159 µM 0.434632971733451 0.33996894035069 no 1136 0.331914429155343 1622 952393
SGTC_2611 pyromycin 23.93 µM 0.434481198373038 0.340022347583505 no 1137 0.331969522553546 1545 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2809 7964133 12.99 µM 0.43427973371456 0.340093245549683 no 1138 0.332042659396299 1596 1253665
SGTC_2096 5468907 200 µM 0.432752926558025 0.340630731990161 no 1139 0.332597137430227 1696 759785
SGTC_2629 bisabolol 100 µM 0.431824450573789 0.340957744529803 no 1140 0.332934503701253 1665 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_47 0149-0135 24.25 µM 0.431761248537033 0.340980008859285 no 1141 0.332957473389903 1464 5239155
SGTC_322 k048-0136 19.3 µM 0.431588764985782 0.341040772861533 no 1142 0.333020162746809 1584 6823282
SGTC_1322 1348-1070 12 µM 0.431290764299423 0.341145764844202 no 1143 0.333128482455329 1566 6758089
SGTC_3307 9126885 69.2785 µM 0.430907480820686 0.34128082185266 no 1144 0.333267821913888 1520 24824909
SGTC_81 0411-0046 9.971 µM 0.430783417378604 0.341324542253113 no 1145 0.33331292905756 1525 12925265
SGTC_368 fentichlor 4.58 µM 0.430051444947111 0.341582535289443 no 1146 0.333579109575488 1555 7329 A pesticide.
SGTC_1742 st038235 28.8875 µM 0.429536042827986 0.341764239774805 no 1147 0.333766584956675 1599 564103 YBR002C RER2
SGTC_158 k038-0087 26.446 µM 0.421581042892091 0.34457339465959 no 1148 0.336665422833628 1613 X158
SGTC_2304 7443016 91.4 µM 0.419505513938361 0.345307747567097 no 1149 0.33742336289831 1581 939854
SGTC_3237 9133362 49.47 µM 0.419226365779412 0.345406558843365 no 1150 0.337525352436871 1657 43845137
SGTC_88 0180-0332 8.668 µM 0.41823702005566 0.345756846620146 no 1151 0.33788691574677 1637 3101745
SGTC_288 1315-0019 35.1 µM 0.418225442159769 0.345760946672772 no 1152 0.337891147856146 1600 6811474
SGTC_1176 0848-0131 83.3 µM 0.417534495269791 0.346005662781844 no 1153 0.338143749211978 1729 6769040
SGTC_1036 k216-0215 33.5 µM 0.417343887166476 0.346073182730762 no 1154 0.338213445930139 1581 622330
SGTC_1314 1222-0010 41.1 µM 0.416599195356323 0.346337025087853 no 1155 0.338485798998426 1619 3526027
SGTC_114 0364-0001 490.298 µM 0.416228313444623 0.346468455408567 no 1156 0.338621471644393 1537 4003655
SGTC_986 1493-0483 84 µM 0.416010434078908 0.346545674467731 no 1157 0.338701184058961 1676 40079
SGTC_740 k014-0057 261 µM 0.415742512578063 0.34664063780154 no 1158 0.338799214580465 1722 4012779
SGTC_2805 7950783 58.44 µM 0.415275805205587 0.346806082730694 no 1159 0.338970005476596 1640 1178958 YDL195W SEC31
SGTC_1266 0828-0227 32.9 µM 0.414852536475817 0.34695615418947 no 1160 0.339124928690492 1652 3913820
SGTC_650 1328-0195 38 µM 0.414198491705117 0.347188095335235 no 1161 0.339364373166486 1670 2780821
SGTC_867 0518-0118 155 µM 0.414119879922955 0.347215976956537 no 1162 0.339393157151007 1627 6848158
SGTC_2426 5582046 32.21 µM 0.413423245168778 0.347463091895403 no 1163 0.33964827338092 1634 2251934
SGTC_1508 1080-0625 72.9 µM 0.413180269337016 0.34754929716515 no 1164 0.339737271414431 1600 767111
SGTC_1245 0418-0076 17.2 µM 0.413000617251778 0.347613040905912 no 1165 0.339803080751514 1638 6790114
SGTC_1391 3442-0225 151 µM 0.411485974981535 0.348150633945278 no 1166 0.34035811159423 1623 5227075
SGTC_770 0389-1121 67.2 µM 0.411418350115537 0.348174643213397 no 1167 0.340382900365549 1728 6753108
SGTC_2612 dictamnine 15.46 µM 0.410795434637768 0.348395829297779 no 1168 0.340611270533197 1610 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_397 arbidol 50 µM 0.406252686977327 0.350010432276486 no 1169 0.342278472640995 1700 131410 A RNA synthesis inhibitor.
SGTC_731 3966-0296 387 µM 0.405289537147146 0.350353109035877 no 1170 0.342632348200109 1623 660956
SGTC_925 2064-1272 59.6 µM 0.405137868947806 0.350407081810876 no 1171 0.342688085948657 1590 6815817
SGTC_1122 capsaicin 818.572 nM 0.404974931047088 0.350465068397086 no 1172 0.34274796910524 1696 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2673 kobusone 100 µM 0.403440398749443 0.351011350868549 no 1173 0.343312136150978 1686 6710676 An epoxy ketone and protein crosslinker.
SGTC_2459 5811157 9.22 µM 0.403314400362768 0.351056219089966 no 1174 0.343358474686041 1595 2870684 YBR192W RIM2
SGTC_811 0416-0114 265 µM 0.403014185365888 0.351163134484684 no 1175 0.343468894502471 1622 6612453
SGTC_2120 5538279 151.968 µM 0.403008002716721 0.351165336431827 no 1176 0.343471168636522 1638 2058197
SGTC_2725 haloperidol 53.21 µM 0.402779114197805 0.351246858469637 no 1177 0.343555363584847 1595 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1769 st044406 64.4 µM 0.402163606610614 0.351466114560842 no 1178 0.343781811990195 1623 670903
SGTC_2921 7974240 10.71 µM 0.399336230552067 0.352473916425484 no 1179 0.344822737293533 1677 2979074 YDR527W RBA50
SGTC_1554 st069299 38.7 µM 0.398701604759585 0.352700267814217 no 1180 0.345056542642315 1661 24207999
SGTC_1428 4049-0204 61.7 µM 0.397904661710748 0.352984586614287 no 1181 0.34535023181458 1716 X1428
SGTC_736 0958-0254 92.6 µM 0.397125274650308 0.353262721526232 no 1182 0.345637541351763 1678 6812352
SGTC_2935 9038016 29.96 µM 0.396273559386295 0.353566757388892 no 1183 0.345951615312337 1682 6463195
SGTC_706 4262-0057 46.9 µM 0.395356221736738 0.353894322924156 no 1184 0.346290006416343 1586 883298
SGTC_291 SEC14.278 35.5 µM 0.393408066933995 0.354590334149274 no 1185 0.347009056234861 1720 1068044
SGTC_884 0851-0618 334 µM 0.392336802884664 0.354973268497489 no 1186 0.347404687107217 1736 9642473
SGTC_2487 5918373 44.05 µM 0.389305006220406 0.356057808533034 no 1187 0.348525266711056 1712 2876279
SGTC_195 4234-0266 16.654 µM 0.38924535747552 0.356079157915774 no 1188 0.348547326732592 1635 2303354
SGTC_1488 4013-0813 75.9 µM 0.387838201228494 0.356582935767205 no 1189 0.34906788672485 1626 2910057
SGTC_1029 k015-0030 64.7 µM 0.387344389077363 0.356759785481405 no 1190 0.349250633807726 1680 2208316
SGTC_929 2805-0021 398 µM 0.386276925654207 0.357142183004355 no 1191 0.349645793775485 1684 3098024
SGTC_1777 st045864 34.765 µM 0.385368419670891 0.357467750278085 no 1192 0.349982238323109 1652 4691462
SGTC_2333 9017922 200 µM 0.385030843472334 0.357588748705342 no 1193 0.350107282031462 1777 3163164
SGTC_3024 9090631 49.47 µM 0.383787541237574 0.358034512542009 no 1194 0.350567961456036 1768 25236383
SGTC_1303 1160-0052 261 µM 0.382506651935292 0.358493955047408 no 1195 0.351042797912582 1670 3562476
SGTC_3218 9131285 49.47 µM 0.381757758678437 0.358762670722978 no 1196 0.351320526795025 1777 17156417
SGTC_2439 5492030 7.2 µM 0.381615558323397 0.358813702539156 no 1197 0.351373271117068 1748 5722370
SGTC_2926 9010726 65.15 µM 0.3812716573218 0.358937129614375 no 1198 0.351500841173959 1611 2994293
SGTC_246 cycloheximide 667 µM 0.380798547245406 0.359106954271762 no 1199 0.351676368663342 1632 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1839 st053978 48 µM 0.379392910447191 0.359611677082574 no 1200 0.352198057197046 1680 3788398
SGTC_3033 9090887 49.47 µM 0.379380069240882 0.359616289112425 no 1201 0.352202824370946 1591 19325384
SGTC_2900 5328528 85.29 µM 0.378392419234324 0.359971073335131 no 1202 0.352569549437393 1598 795359
SGTC_1439 4092-1168 46 µM 0.378254903993401 0.360020481218794 no 1203 0.352620621203579 1685 2886240
SGTC_2816 7982706 58.44 µM 0.376756706689773 0.360558920259461 no 1204 0.353177208450764 1644 2981853
SGTC_2856 9022925 19.48 µM 0.376743292206155 0.360563742558774 no 1205 0.353182193414736 1670 4944862
SGTC_2517 totarol 10 µM 0.376154336510033 0.360775484869215 no 1206 0.353401080403041 1604 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2244 6635614 200 µM 0.374734815040019 0.36128600885591 no 1207 0.353928848607593 1653 836499
SGTC_673 1082-0474 110 µM 0.373597444254834 0.361695237106435 no 1208 0.354351917834685 1637 3098046
SGTC_3103 9120822 49.47 µM 0.371745245429383 0.362362000369203 no 1209 0.355041267159158 1771 17141819
SGTC_1650 st011916 45.8 µM 0.370191784166973 0.362921544905036 no 1210 0.355619798865759 1773 242528
SGTC_2104 5389443 200 µM 0.369277682329537 0.363250934109592 no 1211 0.355960379372684 1748 2244536
SGTC_909 3448-9333 149 µM 0.36835155484205 0.363584759823633 no 1212 0.356305557717555 1609 3344074
SGTC_157 1348-1695 65.819 µM 0.366644673503705 0.364200282112753 no 1213 0.356942040352469 1654 5380510
SGTC_2493 resveratrol 26.09 µM 0.363824540744064 0.365218023682436 no 1214 0.357994517929883 1644 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1432 4049-0298 68.4 µM 0.361506912451178 0.366055130869164 no 1215 0.358860269253387 1805 741646
SGTC_1572 epiandrosterone 68.9 µM 0.360536119840643 0.366405962537866 no 1216 0.35922312524099 1732 441302 A steroid.
SGTC_2877 9040724 71.43 µM 0.359276493298536 0.366861341413268 no 1217 0.359694128821233 1816 6463895
SGTC_2271 7849410 118.62 µM 0.359091409498315 0.366928268523772 no 1218 0.359763353927681 1837 972430
SGTC_1885 st057546 99.9 µM 0.358628621934842 0.367095632225129 no 1219 0.359936466021561 1778 702008
SGTC_143 4032-1194 15.74 µM 0.357650892313419 0.367449303935239 no 1220 0.360302293759178 1680 1806963
SGTC_2128 5255449 168.493 µM 0.357345444173796 0.367559816002339 no 1221 0.360416606610755 1662 736008
SGTC_3311 9131146 2.8755 µM 0.356167015059301 0.367986277955906 no 1222 0.360857746257346 1688 4900406 YPR165W RHO1
SGTC_930 2810-3379 265 µM 0.353217669588721 0.369054329616464 no 1223 0.361962631075368 1826 1015764
SGTC_1237 0330-0133 46.1 µM 0.3526989359055 0.369242284420652 no 1224 0.36215707859258 1697 X1237 YHR072W ERG7
SGTC_2097 5376186 200 µM 0.352331655882519 0.36937538133439 no 1225 0.362294775164131 1797 742755
SGTC_3114 9122766 49.47 µM 0.349553940482473 0.370382490778131 no 1226 0.363336741413328 1655 17176985
SGTC_1558 st069300 45.6 µM 0.348409271178602 0.370797769802564 no 1227 0.363766420403298 1808 24208000
SGTC_1269 0831-0796 3.05 µM 0.346238279659035 0.37158580545395 no 1228 0.364581824370121 1785 927758
SGTC_1219 1469-0211 33.1 µM 0.344788910870694 0.37211220340784 no 1229 0.365126535158186 1818 6822282
SGTC_711 k292-0785 179 µM 0.344130301342005 0.372351483645953 no 1230 0.365374147919292 1665 4146315
SGTC_3125 9127534 49.47 µM 0.344038386947402 0.372384881098974 no 1231 0.365408708788661 1724 1639235
SGTC_1346 1488-2224 62.4 µM 0.342850301104327 0.372816663010707 no 1232 0.365855541001776 1838 3722427
SGTC_2513 baicalein 25.65 µM 0.342765200632371 0.372847596920644 no 1233 0.365887553790512 1622 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1652 st011932 78 µM 0.340801214577158 0.373561730717029 no 1234 0.366626618021342 1793 1551076
SGTC_1284 0929-0043 16 µM 0.339762951063893 0.373939434064834 no 1235 0.367017525293787 1698 1239883
SGTC_174 3553-0389 74.3 µM 0.339490830907669 0.374038446982449 no 1236 0.367120001636701 1756 738071
SGTC_3069 9117009 49.47 µM 0.339003436767453 0.37421580969026 no 1237 0.367303570572286 1767 41904981
SGTC_2308 7584454 197.62 µM 0.335785558846742 0.37538746192518 no 1238 0.368516290453053 1814 893577
SGTC_1612 st002233 45.4 µM 0.335506678885955 0.375489058426414 no 1239 0.368621453686422 1732 1035021
SGTC_2491 paeonol 100 µM 0.335076208403262 0.375645896593774 no 1240 0.368783799715657 1711 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2759 disulfiram 3.38 µM 0.335044539776807 0.375657435593576 no 1241 0.368795744028217 1686 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3173 9105693 49.47 µM 0.334812168318001 0.375742107467103 no 1242 0.368883390395993 1794 17096658
SGTC_1015 4130-4525 82 µM 0.33442618474858 0.375882765984032 no 1243 0.369028991579895 1672 1363237
SGTC_2119 5528445 120.635 µM 0.334351670897601 0.375909921909664 no 1244 0.369057101949022 1811 791935
SGTC_1174 0739-0097 51.1 µM 0.333164514437881 0.376342653575741 no 1245 0.369505051393715 1729 728447
SGTC_110 0850-0284 111.64 µM 0.332029348890795 0.376756579407215 no 1246 0.369933548864403 1725 3906265
SGTC_825 1988-2224 89.6 µM 0.331406754671364 0.376983661860102 no 1247 0.370168631711507 1727 1180859
SGTC_693 4161-2696 114 µM 0.330949778407336 0.377150364588297 no 1248 0.370341210415563 1808 805759
SGTC_1805 st050013 60.3 µM 0.330098591331438 0.37746093453903 no 1249 0.370662733793615 1785 4037144
SGTC_1452 4194-0072 190 µM 0.327262224713639 0.378496401751536 no 1250 0.371734780504896 1874 1343545
SGTC_1531 st059297 52.4 µM 0.327218266878359 0.378512456247442 no 1251 0.371751402872973 1768 7566702
SGTC_2622 2-methoxyxanthone 59.94 µM 0.327049471371441 0.378574106517577 no 1252 0.371815234012115 1875 71034 A hepatoprotective.
SGTC_1146 3579-1023 7 µM 0.326716219817645 0.37869583120131 no 1253 0.371941265639556 1864 X1146
SGTC_1655 st012546 55.1 µM 0.326163512328312 0.378897741691082 no 1254 0.372150323042928 1754 720985 YLR208W SEC13
SGTC_431 k089-0097 107 µM 0.325831844927989 0.379018919530821 no 1255 0.372275791812551 1734 5499420
SGTC_73 0327-0325 16.231 µM 0.324550544183487 0.37948716654851 no 1256 0.372760631258419 1898 53298
SGTC_69 0096-0274 206.684 µM 0.324262520819954 0.37959244807577 no 1257 0.372869646016114 1824 6741392
SGTC_2905 7799065 20.05 µM 0.322646277935218 0.380183400688533 no 1258 0.373481570891811 1845 1296806
SGTC_1943 st076331 65.2 µM 0.321860359349894 0.380470860085337 no 1259 0.373779242546486 1878 24208415
SGTC_554 4483-2211 187 µM 0.321850718007392 0.380474386935252 no 1260 0.373782894734104 1751 747107
SGTC_2281 7943571 200 µM 0.320796887650325 0.380859943030107 no 1261 0.374182159071298 1917 1244024
SGTC_1810 st050138 53 µM 0.319531959224933 0.381322888047425 no 1262 0.3746615802971 1850 3444541
SGTC_17 0960-0276 49.807 µM 0.318348133519421 0.381756304573462 no 1263 0.375110438321701 1773 6821114
SGTC_1996 st072960 66.8 µM 0.316741647898451 0.382344700344412 no 1264 0.37571982208307 1872 1719405
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.315112930005824 0.382941516419436 no 1265 0.376337955770458 1740 91467 include heat shock
SGTC_3043 9092303 49.47 µM 0.314895338155925 0.383021270348611 no 1266 0.376420560647473 1690 25236084
SGTC_1656 st012921 11 µM 0.314465520266751 0.38317882604713 no 1267 0.376583749996817 1842 6732821
SGTC_3127 9126946 49.47 µM 0.312977989598871 0.383724250036931 no 1268 0.377148692221196 1690 27243249
SGTC_3260 9137109 49.47 µM 0.312388580813592 0.38394042884433 no 1269 0.377372613825759 1875 17478346
SGTC_2761 levamisole 97.89 µM 0.310216939788149 0.384737237803439 no 1270 0.378197994727371 1875 26879 An alkaline phosphatase inhibitor.
SGTC_332 4112-0506 40.9 µM 0.30985599100368 0.384869722841656 no 1271 0.378335235415763 1769 2790355
SGTC_1973 st070275 50.2 µM 0.309531068134953 0.384988996186971 no 1272 0.378458791385401 1859 17118334
SGTC_1459 k035-0031 35.7 µM 0.307474781654462 0.385744073939487 no 1273 0.379241007634489 1678 3877128 YMR208W ERG12
SGTC_83 0170-0301 39.027 µM 0.307328733412433 0.385797720026647 no 1274 0.379296583583599 1821 3089716
SGTC_2944 9067346 25.62 µM 0.307002522569 0.385917550891561 no 1275 0.379420726075311 1814 6473075
SGTC_475 α-linolenic acid 10 µM 0.302432276763566 0.387597532779244 no 1276 0.381161276363286 1856 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2280 7785178 200 µM 0.302091776371659 0.387722782418186 no 1277 0.381291050635367 1780 2954328
SGTC_1672 st016598 6.51 µM 0.301713134294827 0.387862075811698 no 1278 0.381435377451668 1738 4665860 YNL267W PIK1
SGTC_2831 7999036 19.48 µM 0.300794563554647 0.38820005602669 no 1279 0.381785577099013 1924 2988270
SGTC_990 3985-0011 41.3 µM 0.300010335336891 0.388488673090906 no 1280 0.382084636045599 1774 5399565 YGL099W LSG1
SGTC_562 3772-2733 112 µM 0.298709504542756 0.388967549504026 no 1281 0.382580852203255 1881 2876874 YIL048W NEO1
SGTC_36 0335-0881 14.2 µM 0.298018733831788 0.389221912399492 no 1282 0.382844432702559 1802 23828853
SGTC_3231 9132313 49.47 µM 0.297562530287662 0.389389926531883 no 1283 0.383018538110271 1807 4905967
SGTC_2781 5567276 71.43 µM 0.295645250377235 0.390096262782028 no 1284 0.383750506361542 1838 2853274
SGTC_2913 7966556 36.57 µM 0.294223534505584 0.390620265107859 no 1285 0.384293549099212 1878 2976516
SGTC_2723 salbutamol 83.58 µM 0.294065097886229 0.390678672472533 no 1286 0.384354080101114 1871 9884233 β2-adrenoceptor agonist
SGTC_107 0358-0022 2.6945 µM 0.293700963647503 0.390812919228776 no 1287 0.384493208944026 1881 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2772 vinpocetine 57.06 µM 0.293290756318102 0.390964167514467 no 1288 0.384649959270742 1863 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2367 9070478 135.38 µM 0.293224614239097 0.390988556424695 no 1289 0.384675235554927 1759 572802
SGTC_2267 7931562 200 µM 0.292895125697455 0.391110056821289 no 1290 0.384801157344596 1666 934880
SGTC_2747 doxorubicin 7.63 µM 0.291563962431689 0.391601037414128 no 1291 0.385310016271571 1900 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1225 1216-0074 20.6 µM 0.289877589630528 0.392223279908096 no 1292 0.385954943382037 1771 4241466
SGTC_2073 5212005 126 µM 0.2896309509112 0.392314308490555 no 1293 0.38604929300607 1936 691789
SGTC_444 curcumin 90.4 µM 0.288945279600936 0.392567404681686 no 1294 0.386311626353996 1836 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_72 0744-0168 198.391 µM 0.287315757362624 0.393169078912453 no 1295 0.386935279222441 1825 677577
SGTC_3291 9121177 71.43 µM 0.285490233045082 0.393843426811393 no 1296 0.387634293049708 1772 17015612
SGTC_312 4092-0653 6.84 µM 0.285288953752921 0.393917798823444 no 1297 0.387711387501135 1885 1148278
SGTC_155 k072-0202 43.6 µM 0.283187804540813 0.39469439681358 no 1298 0.388516438225853 1920 5857737
SGTC_827 3253-0474 693 µM 0.282713001387186 0.394869945152284 no 1299 0.388698424505487 1926 5402065
SGTC_2216 7189485 200 µM 0.282362623342563 0.394999503650884 no 1300 0.388832735820727 1893 731273
SGTC_1111 tnp00062 510.699 nM 0.280744564020465 0.395597960193976 no 1301 0.389453162798033 1925 676306
SGTC_2006 4011487 200 µM 0.280594586706596 0.395653443398915 no 1302 0.389510684241172 1908 45595294
SGTC_627 1391-0720 175 µM 0.279744306400019 0.39596803943092 no 1303 0.389836841628217 1832 997839
SGTC_285 1486-1325 46 µM 0.276690032989001 0.397098650589228 no 1304 0.391009062862472 1893 22310230
SGTC_3354 9151612 71.43 µM 0.276017372125509 0.397347768439746 no 1305 0.391267361661357 1935 27261949
SGTC_24 0417-1663 219 µM 0.275618056762784 0.397495673454125 no 1306 0.391420719689711 1804 4329390
SGTC_1140 3229-1848 2.98 µM 0.274731648162037 0.397824048743105 no 1307 0.391761207340063 1936 2849525
SGTC_1637 st007924 17.4 µM 0.274592723092965 0.397875520922294 no 1308 0.391814578820245 1796 683336
SGTC_2596 sinensetin 100 µM 0.2742621625453 0.397998001800277 no 1309 0.391941579964285 1777 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.272693820839831 0.398579248081887 no 1310 0.392544292504848 1826 4620898
SGTC_2033 5192550 145 µM 0.270910379241284 0.399240486379606 no 1311 0.393229980983689 1793 182073
SGTC_2289 7946404 165.07 µM 0.270590702595989 0.399359042013125 no 1312 0.393352923701324 1797 1246120 YPR165W RHO1
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.270353225040743 0.399447119210742 no 1313 0.393444260799501 1823 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3095 9117207 49.47 µM 0.268783359713658 0.400029489466801 no 1314 0.394048199651973 1966 17015229
SGTC_715 0868-0130 184 µM 0.268778402495031 0.400031328790647 no 1315 0.394050107135233 1981 2876258
SGTC_713 1488-1073 324 µM 0.267568741979276 0.400480226810205 no 1316 0.394515647083738 1964 3312542
SGTC_3244 9134489 49.47 µM 0.266613504499908 0.400834802855877 no 1317 0.394883378408768 1804 16584271
SGTC_317 4495-0002 170 µM 0.266539729386 0.400862190954902 no 1318 0.394911783016755 1807 15991618
SGTC_962 1254-0300 21.5 µM 0.266208144517589 0.400985293753303 no 1319 0.395039455430472 1828 7340576
SGTC_975 1335-0046 28.5 µM 0.265705855305246 0.401171790249338 no 1320 0.395232876780131 1738 16486740
SGTC_1976 st070609 63.5 µM 0.265081850264608 0.401403510349949 no 1321 0.395473204369766 1871 682556
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.265055625683214 0.401413249432838 no 1322 0.395483305304231 1906 616764
SGTC_485 niflumic acid 177 µM 0.264547749788143 0.401601872539078 no 1323 0.395678937942614 1890 4488 A COX2 inhibitor.
SGTC_578 3460-0051 92 µM 0.264437825685907 0.401642700937291 no 1324 0.395721283918531 1958 2876744
SGTC_370 0180-0345 38.7 µM 0.263939557108357 0.401827783069033 no 1325 0.395913246961476 1799 3989527
SGTC_2054 5233173 129 µM 0.261054072148666 0.402900029763084 no 1326 0.397025404478412 1885 6889
SGTC_2002 4023503 131 µM 0.260687200878804 0.403036411711059 no 1327 0.397166868545257 2039 4736863 YCR052W RSC6
SGTC_3094 9117742 49.47 µM 0.260670834979691 0.403042495899898 no 1328 0.39717317948465 1818 17149698
SGTC_276 colchicine 750 µM 0.259473923483791 0.40348752342239 no 1329 0.397634799628986 1873 2833 A microtubule depolymerizer.
SGTC_718 1130-0073 349 µM 0.258723398454939 0.403766642356018 no 1330 0.397924332370368 1897 6740020
SGTC_3019 9081971 49.47 µM 0.258287198169525 0.403928887002783 no 1331 0.398092632769519 1968 16451803
SGTC_176 1486-1328 72.834 µM 0.257721781062803 0.404139218427545 no 1332 0.39831081747934 1806 22310231
SGTC_2679 rapamycin 1 nM 0.257549340982453 0.404203370515005 no 1333 0.398377365462605 1865 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.256269429797738 0.404679610379975 no 1334 0.398871400358648 1811 2374 Ca(2+)-ATPase inhibitor.
SGTC_3159 9100096 49.47 µM 0.255968638800747 0.404791551687244 no 1335 0.398987526688018 1861 25236875
SGTC_3298 9116858 71.43 µM 0.255720060973915 0.404884067407944 no 1336 0.399083501835894 1934 2506942
SGTC_2993 9054257 71.4286 µM 0.254730379686202 0.405252459763961 no 1337 0.399465675235693 1838 6470217 YGL055W OLE1
SGTC_27 0485-0001 32.618 µM 0.252666173313186 0.406021095998026 no 1338 0.400263094825274 1956 2054479
SGTC_1809 st050081 57.6 µM 0.251343026538828 0.40651397907184 no 1339 0.40077445610095 1933 5036894
SGTC_2638 epoxomicin 18 µM 0.25124633261243 0.406550004174356 no 1340 0.400811832428478 1968 9915668 A protesome inhibitor.
SGTC_850 0388-0143 75.9 µM 0.250483853293282 0.406834107568673 no 1341 0.40110659499775 1852 67273
SGTC_2865 9030313 51.95 µM 0.247044628561006 0.408116186292218 no 1342 0.402436842820978 1789 42562754
SGTC_1552 6-methylflavone 10.6 µM 0.246858429467845 0.408185626046853 no 1343 0.402508894630085 1981 689013
SGTC_1801 st050089 28.441 µM 0.246396459615157 0.40835792221864 no 1344 0.402687673297395 1885 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2340 7987427 183.45 µM 0.245908109923132 0.408540076272968 no 1345 0.402876682879938 1904 2239331
SGTC_2441 5730946 39.09 µM 0.245752827263169 0.408598000726624 no 1346 0.40293678783139 1941 1774275
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.24531469029073 0.408761447925476 no 1347 0.40310638900274 1915 4000243
SGTC_636 0kpi-0074 126 µM 0.245079800948436 0.408849080038603 no 1348 0.403197321290536 1860 616434
SGTC_1814 st052110 31.539 µM 0.245071968682448 0.408852002165499 no 1349 0.403200353471767 1966 674163
SGTC_131 0141-0277 33.849 µM 0.244387998496212 0.409107202969624 no 1350 0.403465167922634 1964 1547771
SGTC_3027 9089541 49.47 µM 0.244081177919938 0.409221695423396 no 1351 0.403583974804177 1866 9943819
SGTC_2636 apigenin dimethyl ether 100 µM 0.243551310785553 0.409419437643036 no 1352 0.4037891705868 1899 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_754 3474-0146 171 µM 0.243249711521099 0.409532002397108 no 1353 0.403905979427229 1756 24762078
SGTC_29 0299-0004 12.984 µM 0.243069149897319 0.409599396299597 no 1354 0.403975914713781 1965 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2430 5571206 200 µM 0.242823323640669 0.409691154258525 no 1355 0.404071133288949 1995 1731771
SGTC_2253 7938677 135.83 µM 0.242793897032191 0.409702138467799 no 1356 0.404082531800389 1994 2301972
SGTC_2162 5663267 200 µM 0.242099085598939 0.409961514591061 no 1357 0.404351693358468 1969 6456493
SGTC_253 dyclonine 31.25 µM 0.241912943123742 0.410031009081442 no 1358 0.404423810400728 1922 3180 An oral anasthetic.
SGTC_3063 1327-0034 4 µM 0.241307415241814 0.410257096589483 no 1359 0.404658432075615 1950 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2296 7971656 126.45 µM 0.240506899710454 0.410556032915482 no 1360 0.404968657511805 1848 666570
SGTC_1693 xanthone 101.9 µM 0.239345163031954 0.410989952361674 no 1361 0.405418973919852 1940 7020 An insecticide.
SGTC_302 1094-0063 18.9 µM 0.237284277132068 0.411759980118676 no 1362 0.406218129435594 1876 5440289
SGTC_1462 k081-0014 26.5 µM 0.237258658221291 0.411769554493264 no 1363 0.406228066219058 1871 3270634
SGTC_1615 st002656 86.5 µM 0.236347733224771 0.412110022157698 no 1364 0.40658142507172 1877 1584458
SGTC_616 4092-0450 108 µM 0.235914809167495 0.412271855224099 no 1365 0.406749388252955 1918 787165
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.235381840481692 0.412471106856357 no 1366 0.40695618968362 1903 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_652 0437-0092 114 µM 0.234955618998348 0.412630467025905 no 1367 0.407121589954288 1852 3091274
SGTC_1609 st001574 46.4 µM 0.232314669962818 0.413618212935475 no 1368 0.408146809558236 1842 3960012
SGTC_2765 myclobutanil 7.74 µM 0.232243813076218 0.413644721802666 no 1369 0.408174324984562 1896 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_717 1532-0246 73.2 µM 0.232068935757727 0.413710148314668 no 1370 0.408242235973764 1883 9561992
SGTC_675 1309-0189 238 µM 0.232031176485729 0.413724275432398 no 1371 0.408256899583755 1871 4246530
SGTC_399 oxolinic acid 75 µM 0.23092790656831 0.414137098081075 no 1372 0.408685405151325 1890 4628 A DNA gyrase inhibitor.
SGTC_283 0987-0079 11.7 µM 0.228655262523657 0.414987776883203 no 1373 0.409568434455239 1991 411556
SGTC_2447 5741742 33.78 µM 0.227244575358622 0.415516015392441 no 1374 0.410116784045046 1938 1776504
SGTC_1720 st037298 9.481 µM 0.226208590922092 0.415904042000963 no 1375 0.410519594595254 1875 597396
SGTC_1456 k015-0012 13 µM 0.225785913095701 0.416062378998932 no 1376 0.410683966953269 2065 2989616
SGTC_1474 0330-0125 5.35 µM 0.225554489917568 0.416149076926889 no 1377 0.410773970215734 1955 X1474
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.223900701598214 0.416768753186758 no 1378 0.41141728489625 1869 6708784 An antioxidant flavonoid
SGTC_2132 5317594 122.667 µM 0.221970813850586 0.417492145665766 no 1379 0.412168301876461 1920 794577
SGTC_1394 3474-0001 65.7 µM 0.221810416463104 0.417552281076426 no 1380 0.412230735136761 1900 5017666 YIL048W NEO1
SGTC_1726 st035556 14.5795 µM 0.221606922663465 0.417628576759788 no 1381 0.412309946489713 1994 5919439
SGTC_573 3702-0553 84.7 µM 0.220810337337391 0.417927269331187 no 1382 0.412620057106612 1902 1222756
SGTC_509 pifithrin 175 µM 0.217269033130093 0.419255709524812 no 1383 0.413999344324442 1997 4817 A p53 inhibitor.
SGTC_542 3381-0244 89.3 µM 0.215969423195879 0.419743460618461 no 1384 0.414505790931444 2029 1112843
SGTC_1574 spiramycin 23.7 µM 0.215896393004149 0.419770872936505 no 1385 0.41453425438398 1935 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2718 lomofungin 53.02 µM 0.215395320868748 0.419958963842767 no 1386 0.414729558900284 2009 5351222 A RNA synthesis inhibitor.
SGTC_2646 retinol 96.75 µM 0.21380001215325 0.420557927460462 no 1387 0.415351507738029 1966 445354 A vitamin A analog and teratogen.
SGTC_135 0933-0004 26.348 µM 0.212182021530354 0.421165594995956 no 1388 0.415982516077132 1863 21230617 YGL099W LSG1
SGTC_2393 9031399 185.94 µM 0.21000613436845 0.421983087238999 no 1389 0.416831442631638 1997 1526623 YDL150W RPC53
SGTC_2892 9047358 58.44 µM 0.208801659831812 0.422435759477163 no 1390 0.417301537769205 1920 6466771
SGTC_3179 9107801 49.47 µM 0.208213561794771 0.422656818978197 no 1391 0.417531109929676 1932 4818259
SGTC_2639 lactacystin 53 µM 0.208105022080001 0.422697620512781 no 1392 0.417573482976063 2009 3870 A proteasome inhibitor.
SGTC_1665 st014639 11.4 µM 0.207187943034757 0.423042395891204 no 1393 0.417931541544059 1996 981133 YIL048W NEO1
SGTC_2247 cerulenin 830 nM 0.206245512999169 0.423396763374963 no 1394 0.418299568877961 2025 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_586 0957-0265 8.15 µM 0.205821322377039 0.423556285497907 no 1395 0.418465242465047 2067 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_764 1951-2361 146 µM 0.203718368193194 0.424347311935406 no 1396 0.419286793726094 1855 5438930
SGTC_3208 9114115 49.47 µM 0.202430743936516 0.424831802606618 no 1397 0.419789997850055 1822 650895
SGTC_1717 st033143 58.0435 µM 0.201413632498841 0.425214588524262 no 1398 0.420187578221252 2042 674616
SGTC_1877 wortmannin 25 µM 0.200476469861029 0.425567348449671 no 1399 0.420553979387199 2061 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2116 5511452 16.8835 µM 0.199776186232595 0.425830983020919 no 1400 0.420827813257585 1989 870744
SGTC_2450 5739737 12.93 µM 0.199253188334476 0.426027896773626 no 1401 0.421032347589946 1951 2262825
SGTC_1152 3909-8331 15.9 µM 0.198183685258986 0.426430632374109 no 1402 0.421450675800279 1924 16001939
SGTC_1647 st011722 22.4 µM 0.197583919977846 0.426656515568905 no 1403 0.421685308387798 2017 2854783
SGTC_1724 st037281 8.293 µM 0.197435884077008 0.426712272454375 no 1404 0.421743225402372 1913 574124 YDL195W SEC31
SGTC_2109 5483026 200 µM 0.196810361077087 0.426947888312888 no 1405 0.421987971365664 1945 759335
SGTC_3175 9106517 49.47 µM 0.196667001508826 0.427001891261256 no 1406 0.422044067356718 1937 41468073
SGTC_2263 7948595 193.29 µM 0.196185009110977 0.427183465803871 no 1407 0.422232680529254 1909 2971371
SGTC_1515 3460-0031 42.1 µM 0.195927732947706 0.427280392325909 no 1408 0.422333365091852 2009 2876596
SGTC_516 3992-2719 87.3 µM 0.195425127700603 0.427469757073017 no 1409 0.422530073385599 1846 5350887 YDR037W KRS1
SGTC_1366 1683-0113 21.9 µM 0.195389771833737 0.427483078603735 no 1410 0.422543911597925 1936 708623
SGTC_1079 idarubicin 2.36 µM 0.194778411147593 0.427713442691096 no 1411 0.422783211995534 2084 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2288 7946289 167.31 µM 0.194564054411083 0.427794219334038 no 1412 0.422867122821615 2041 1246052
SGTC_202 3594-0513 34.79 µM 0.193596667603023 0.428158799985165 no 1413 0.423245853847848 2062 708429
SGTC_1072 oxiconazole 14.9 nM 0.193508616872648 0.428191986858086 no 1414 0.423280329153299 2012 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_338 4055-0136 114 µM 0.192205506388343 0.428683196633991 no 1415 0.423790616423145 1920 2900563
SGTC_1597 7-benzyloxygramine 47.5 µM 0.192160899431314 0.428700013264653 no 1416 0.423808086405411 1913 260807
SGTC_1352 1496-0991 99 µM 0.191185378995883 0.429067812585414 no 1417 0.424190179102218 1936 3000039
SGTC_1807 st050092 58.9 µM 0.191065736596702 0.429112925465124 no 1418 0.424237045655139 1972 5008496
SGTC_1141 3253-0389 52.6 µM 0.190863607383918 0.42918914328231 no 1419 0.424316226536469 2060 5402031
SGTC_3216 9129716 49.47 µM 0.190449164423808 0.429345427500429 no 1420 0.42447858747702 1954 8056934
SGTC_988 1497-1057 103 µM 0.189376952569269 0.429749804173765 no 1421 0.424898693402639 2109 3533044
SGTC_3066 9117245 49.47 µM 0.189264891914985 0.429792071272299 no 1422 0.424942605091307 2013 17176980
SGTC_2059 5238311 157 µM 0.187205435037092 0.430569001138084 no 1423 0.425749781815565 1937 703021
SGTC_3296 9122258 64.045 µM 0.185459713741296 0.431227784940778 no 1424 0.426434237929989 1958 4730474
SGTC_2602 kawain 100 µM 0.185205954922054 0.431323562019383 no 1425 0.426533749271216 2110 5369129
SGTC_2908 7930301 100 µM 0.184178155006882 0.431711529379915 no 1426 0.42693684804926 2027 2223178
SGTC_1831 st055328 12 µM 0.183264157589725 0.432056594652447 no 1427 0.427295378088183 2076 1103068
SGTC_260 nsc-65238 3.989 µM 0.182519406483304 0.432337801998638 no 1428 0.427587562987792 2048 3246252
SGTC_618 k072-0232 33.2 µM 0.181674076227404 0.432657028119447 no 1429 0.427919255778979 2000 5872756 YGL099W LSG1
SGTC_902 1120-0002 2.07 µM 0.17951295262008 0.433473342965812 no 1430 0.428767473902472 2050 3280475
SGTC_502 l-744,832 89.3 µM 0.177748109172223 0.434140182816955 no 1431 0.429460400570334 2094 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2220 6782180 200 µM 0.176989585792746 0.434426845901654 no 1432 0.429758284886743 2086 833803
SGTC_2685 mycophenolic acid 18.85 µM 0.176383304674854 0.43465599800601 no 1433 0.429996409988072 2060 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1835 st008666 49.2 µM 0.176282851341451 0.434693967816802 no 1434 0.430035866853652 1948 690455
SGTC_3277 9138724 49.47 µM 0.174968921053122 0.43519066853977 no 1435 0.430552027122472 2021 15943418
SGTC_438 sphingosine 6.67 µM 0.174903850861763 0.435215269473539 no 1436 0.430577592184412 1831 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2949 9072542 2.23 µM 0.173514589682673 0.435740563848502 no 1437 0.431123480454674 1973 16457352
SGTC_1587 estradiol valerate 56.1 µM 0.173044021578569 0.435918516390352 no 1438 0.431308412659197 2103 13791 A steroid.
SGTC_2544 sphondin 68.51 µM 0.171921332298905 0.436343130887841 no 1439 0.431749687766762 2070 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_991 3996-0057 64.7 µM 0.171131571080769 0.436641872003785 no 1440 0.43206015594917 2022 715343
SGTC_2446 5162541 200 µM 0.16786179849571 0.43787910386728 no 1441 0.433346002000861 1976 1549321
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.167672109939401 0.437950897872565 no 1442 0.433420619282653 2055 6312947
SGTC_537 1334-0398 209 µM 0.167614118349666 0.437972847145263 no 1443 0.433443431753543 2131 5846986
SGTC_186 3455-3465 67.277 µM 0.165502210396905 0.438772313980259 no 1444 0.434274355089932 2053 755278
SGTC_1050 3232-1156 69.3 µM 0.165426841964668 0.438800849482889 no 1445 0.434304013944838 1968 700529
SGTC_592 k241-0073 46.5 µM 0.164873895326642 0.439010212239136 no 1446 0.434521619845952 2121 4230158
SGTC_1374 2889-5571 141 µM 0.164627806223598 0.439103394700838 no 1447 0.434618471815022 1993 2853281
SGTC_2986 9022445 71.43 µM 0.164441956092414 0.439173769711487 no 1448 0.43469161845583 2113 6459286
SGTC_2791 5663188 71.43 µM 0.163710335850454 0.43945082762995 no 1449 0.434979590250008 2088 54690634
SGTC_1953 st076800 12.1 µM 0.162827643369071 0.439785134697703 no 1450 0.435327071229403 1897 297591
SGTC_2125 5246583 200 µM 0.162054400777669 0.440078024488093 no 1451 0.435631507182423 2136 835267
SGTC_803 4488-1585 147 µM 0.161583582498679 0.44025637769474 no 1452 0.435816893335721 2100 747204
SGTC_2177 5811945 192 µM 0.161266320432101 0.440376568284991 no 1453 0.435941824212181 2080 5343475
SGTC_1232 0279-0259 161 µM 0.160087485465324 0.440823202559374 no 1454 0.436406079592886 1969 1560000
SGTC_1699 st031318 29.054 µM 0.159968670385418 0.440868223128771 no 1455 0.436452876883457 2091 5340658
SGTC_3132 9126706 49.47 µM 0.158572857314051 0.441397171814169 no 1456 0.437002707450526 2053 850858
SGTC_1757 st041620 31.8375 µM 0.158031459590143 0.441602364736119 no 1457 0.437216004510379 1983 5289815
SGTC_2232 chlorophetanol 41.5365 µM 0.156080280485201 0.442342002738711 no 1458 0.43798487087551 2125 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1794 st048918 76.9 µM 0.15584133203612 0.442432595351952 no 1459 0.438079045184155 2133 672303
SGTC_614 0462-0418 107 µM 0.155450471109503 0.442580789086053 no 1460 0.438233098761625 2095 5188303
SGTC_1294 1000-1494 117 µM 0.155246915070094 0.44265796992361 no 1461 0.438313331865947 1985 712797 YDL207W GLE1
SGTC_569 4130-2812 160 µM 0.154312061565662 0.443012459314335 no 1462 0.438681843736216 2162 743552
SGTC_1661 st013063 9.66 µM 0.15365825565212 0.443260404707275 no 1463 0.438939600476751 2062 721395
SGTC_880 0833-0487 87.2 µM 0.153424853154601 0.443348924242757 no 1464 0.43903162346154 2020 76075
SGTC_2490 carminic acid 95.39 µM 0.153089207331449 0.443476225232199 no 1465 0.439163963427293 2068 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1118 chelidonine 707.474 nM 0.150324395750783 0.444525061000861 no 1466 0.44025434332664 2167 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1378 2093-0007 380 nM 0.149565897466957 0.444812866789874 no 1467 0.440553557676605 2035 3618014
SGTC_1242 0402-0103 60.1 µM 0.1487516887609 0.445121843805759 no 1468 0.440874786590313 2094 432868
SGTC_2931 9014674 55.67 µM 0.148571858769672 0.445190090434666 no 1469 0.44094573998264 2080 2996810
SGTC_2499 avocadenofuran 51.48 µM 0.147370504163377 0.445646053750113 no 1470 0.441419792783827 2037 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2134 5324836 1.464 µM 0.146599753769479 0.445938623017554 no 1471 0.441723974023329 2071 699272
SGTC_1326 1431-2094 10.8 µM 0.146072387413652 0.44613882307022 no 1472 0.441932122116351 1998 616278
SGTC_1641 st009299 47.1 µM 0.145730485915855 0.446268623858782 no 1473 0.442067076999658 2155 4046054
SGTC_2678 equilin 100 µM 0.144984755318855 0.446551755823346 no 1474 0.442361454050094 2148 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2462 5162487 171.77 µM 0.14445742007666 0.446751985954004 no 1475 0.442569638785877 2158 2259986
SGTC_1486 3970-0793 4.53 µM 0.144214758579913 0.446844129520396 no 1476 0.442665443554993 2167 2844330
SGTC_3333 9141820 12.094 µM 0.143353197992263 0.447171304962345 no 1477 0.443005621858383 2030 1939433
SGTC_2776 terbinafine 19.92 µM 0.14203253486324 0.447672893150632 no 1478 0.443527153542558 2161 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2818 7996756 12.99 µM 0.141081272724285 0.448034234647489 no 1479 0.443902868934894 2090 2241621
SGTC_1501 4491-0275 38.4 µM 0.140381356038028 0.448300128920518 no 1480 0.444179343852706 2177 5104718
SGTC_1000 4048-0884 8.67 µM 0.140254625430058 0.44834827562756 no 1481 0.444229406768652 2073 13040088
SGTC_691 1548-0686 185 µM 0.140048551990277 0.448426567395579 no 1482 0.444310814711009 2025 46495133
SGTC_738 1315-0003 72.4 µM 0.13954574121251 0.448617604536161 no 1483 0.444509456619184 2149 6251474
SGTC_2492 derrusnin 100 µM 0.138640754557052 0.448961473742563 no 1484 0.444867018401821 2056 1715307 Part of coumarin class of compounds.
SGTC_2479 5617353 43.85 µM 0.137214839708201 0.449503358556518 no 1485 0.445430490733242 2110 2731746
SGTC_2150 5556613 200 µM 0.13713810766052 0.449532521414477 no 1486 0.445460815726326 2079 743190
SGTC_1961 st076550 68.7 µM 0.135817559324026 0.450034452903503 no 1487 0.445982754678784 2087 1579337
SGTC_608 k048-0125 159 µM 0.133727760342995 0.450828934399994 no 1488 0.446808926371391 2151 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1404 3909-7820 48.3 µM 0.133723310936261 0.450830626147865 no 1489 0.446810685627363 2174 23741373
SGTC_1249 0481-0015 10.2 µM 0.133508200378906 0.450912416280217 no 1490 0.446895739682405 2088 4227577
SGTC_1832 st054113 55 µM 0.13210391515124 0.451446409869935 no 1491 0.447451049606205 2181 1251267
SGTC_1335 1486-0900 202 µM 0.13074814227713 0.451962039531079 no 1492 0.447987273587063 2185 X1335
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.129894776938563 0.452286634387077 no 1493 0.448324838339096 2166 3256 An antibiotic and ribosome inhibitor.
SGTC_1321 1326-2144 215 µM 0.129133823146937 0.452576105539051 no 1494 0.448625879529787 2173 3513030
SGTC_2650 prasterone 100 µM 0.127489201777147 0.453201814778006 no 1495 0.449276609588723 2169 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1332 1480-0653 17.5 µM 0.125767622781074 0.453856927622269 no 1496 0.449957935750982 2215 5749438
SGTC_2782 7736369 71.43 µM 0.124428414620355 0.454366623730507 no 1497 0.450488038275083 2066 2950836 YOL077C BRX1
SGTC_944 3370-0224 231 µM 0.124035464271701 0.454516193019042 no 1498 0.450643597719482 2077 4580514
SGTC_1135 dihydrocapsaicin 536.708 nM 0.123315623577051 0.454790203790525 no 1499 0.450928584716734 2102 107982 A Capsaicinoid.
SGTC_1086 cerivastatin 2.18 µM 0.122885874475646 0.454953800086498 no 1500 0.451098735689034 2204 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3302 9125395 16.351 µM 0.121717376052555 0.455398661006887 no 1501 0.45156142572977 2092 17599668
SGTC_1796 st049173 110.4 µM 0.121448292008778 0.455501112370715 no 1502 0.451667984219343 2189 94134
SGTC_1550 gossypolone 36.6 µM 0.120216296115148 0.455970221572837 no 1503 0.45215590448079 2195 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1798 st045719 60.953 µM 0.119100377250361 0.45639518492516 no 1504 0.452597915934617 2194 3980186
SGTC_3349 9149703 23.001 µM 0.118542709119709 0.456607574390737 no 1505 0.452818828327796 2196 4910494
SGTC_879 0831-1030 162 µM 0.117780597014467 0.456897846950907 no 1506 0.453120751932075 2152 1549252
SGTC_2465 5809242 33.21 µM 0.117554017117748 0.456984150936644 no 1507 0.453210520626017 2136 2731748
SGTC_111 0083-0039 52.457 µM 0.117172422773118 0.457129504306179 no 1508 0.453361709899314 2214 759313
SGTC_2258 7960471 200 µM 0.117064441567104 0.457170636545064 no 1509 0.453404493732261 2041 2974708
SGTC_3194 9111903 49.47 µM 0.115646409371447 0.457710836277892 no 1510 0.453966390139102 2154 17087251
SGTC_2974 9094440 9.66 µM 0.114931963080781 0.457983034440151 no 1511 0.454249525041677 2139 25236134
SGTC_1762 st045503 25.4615 µM 0.113638640709136 0.458475829670458 no 1512 0.454762127444416 2096 4645554
SGTC_1968 st069590 43.6 µM 0.112912729378068 0.458752452020736 no 1513 0.455049872144386 2184 6384066
SGTC_164 4100-3994 89.624 µM 0.112712725384358 0.45882867087069 no 1514 0.455129156073148 2209 4615967
SGTC_2586 curcumin 80 µM 0.112380414760751 0.458955313354957 no 1515 0.455260891852081 2181 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1074 carmofur 3.8 µM 0.111442502616889 0.459312771012643 no 1516 0.455632728866383 2209 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_928 2764-0428 58.7 µM 0.110818494687529 0.459550611543229 no 1517 0.45588013952276 2129 662578
SGTC_2330 7979373 200 µM 0.110478215442592 0.459680315032526 no 1518 0.456015062829927 2068 1863007
SGTC_381 3461-2219 42.7 µM 0.109308324655504 0.46012627237659 no 1519 0.456478972020973 2202 2883159
SGTC_1657 st012939 43.4 µM 0.107882856315151 0.46066972253287 no 1520 0.457044308210893 2193 24207257
SGTC_1930 st074634 34.3 µM 0.107630052709385 0.460766109895535 no 1521 0.457144578423002 2214 684253 YOR116C RPO31
SGTC_1129 3453-1384 223 µM 0.10417488257863 0.462083704018278 no 1522 0.458515283149556 2141 1084452
SGTC_1302 1159-0335 255 µM 0.102937939286158 0.462555501734917 no 1523 0.459006113214098 2151 649284
SGTC_1824 st053723 68.6 µM 0.102090848186501 0.462878631578028 no 1524 0.459342282574334 2101 675225
SGTC_1168 k815-0004 80.5 µM 0.0997206924761117 0.463782876384847 no 1525 0.460283036103048 2190 642433
SGTC_35 0133-0054 64.071 µM 0.0984981842766662 0.464249352391083 no 1526 0.460768356843648 2145 99677
SGTC_2476 5806916 10.51 µM 0.0981518916378016 0.464381497239885 no 1527 0.46090584142153 2173 2870194
SGTC_1614 st002383 48.6 µM 0.0980914545129465 0.464404560376151 no 1528 0.460929836556527 2262 1947235
SGTC_1006 4099-6547 255 µM 0.0971240150090948 0.464773756791373 no 1529 0.461313954898702 2179 3146833
SGTC_1998 st075797 76.8 µM 0.0970417727311964 0.464805143675568 no 1530 0.461346610566129 2248 24208315
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0968679675106962 0.464871475295952 no 1531 0.4614156236834 2177 6708514
SGTC_2442 5158906 48.48 µM 0.0963988079922097 0.465050531812344 no 1532 0.461601919400339 2197 1893835
SGTC_1323 1348-1351 11.2 µM 0.0955797616282302 0.465363140915546 no 1533 0.461927169739587 2103 6989654
SGTC_1255 0566-0045 221 µM 0.0953230107365892 0.465461140591025 no 1534 0.462029132974075 2158 2788469
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0950964642535337 0.465547613235236 no 1535 0.462119103233482 2113 803109
SGTC_2860 9025725 38.96 µM 0.0950522399829533 0.465564493800258 no 1536 0.462136666606359 2068 40546248
SGTC_1271 0832-2808 169 µM 0.0937727121804113 0.466052920927639 no 1537 0.462644854336053 2225 3663794
SGTC_1668 st014914 51.6 µM 0.0934915638692744 0.466160249007802 no 1538 0.46275652569946 2213 2839556
SGTC_3267 9137951 49.47 µM 0.092830849064971 0.466412485882639 no 1539 0.463018971406247 2094 16643986
SGTC_2801 7907800 81.82 µM 0.092765740905242 0.466437342541201 no 1540 0.463044834204821 2135 6620925
SGTC_2576 guaiol 23.12 µM 0.0921860112961831 0.466658674492652 no 1541 0.46327512604217 2236 227829
SGTC_965 1291-5240 308 µM 0.0904165608267856 0.467334287257152 no 1542 0.463978098478989 2217 2834598
SGTC_917 harmaline 728.087 nM 0.0896375936473019 0.467631742979595 no 1543 0.464287604615091 2196 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1873 rapamycin 2 nM 0.0895237097252524 0.467675232112352 no 1544 0.464332855798464 2179 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1012 4112-3522 18 µM 0.0893560361349536 0.467739262739765 no 1545 0.46439948086591 2238 3112398
SGTC_2266 7929956 200 µM 0.0884921095860474 0.468069189302015 no 1546 0.464742777687812 2265 2967153
SGTC_544 k015-0020 52.4 µM 0.0883591590470451 0.46811996399073 no 1547 0.464795610323056 2166 3008304
SGTC_181 1447-1644 8.07 µM 0.0883259571551302 0.468132644093446 no 1548 0.464808804375065 2242 534600
SGTC_1361 1608-0041 5.61 µM 0.0870456982569736 0.468621611079158 no 1549 0.465317593988251 2201 X1361
SGTC_804 1595-0054 20.9 µM 0.0856144526399083 0.46916830015846 no 1550 0.465886454550252 2111 761523 Stimulates phospholipase C.
SGTC_707 0865-0008 204 µM 0.0855789050102089 0.469181878936093 no 1551 0.465900584145479 2194 723043
SGTC_2399 5884133 200 µM 0.0852742543107727 0.469298253398649 no 1552 0.46602167952375 2169 722445
SGTC_1564 D-Arginine 115 µM 0.083015410014109 0.470161197476595 no 1553 0.466919643244674 2150 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1009 4106-0057 9.87 µM 0.0823654667732344 0.470409520801011 no 1554 0.467178048118261 2269 2928005
SGTC_3327 9140648 26.9345 µM 0.0820920074266598 0.470514004652527 no 1555 0.467286774411228 2237 8029710
SGTC_3067 9117431 49.47 µM 0.0820630001464654 0.470525087926855 no 1556 0.467298307727892 2168 17150885
SGTC_2997 9067075 71.4286 µM 0.0798689992724471 0.471363450401058 no 1557 0.468170723017589 2204 27209819
SGTC_2352 9027995 87.8 µM 0.0795906881104889 0.471469806650898 no 1558 0.468281400766387 2198 2997347
SGTC_2708 st078559 56 µM 0.0795056537494118 0.471502302827937 no 1559 0.468315217404509 2260 17250902
SGTC_1395 3486-0190 4.35 µM 0.0792806017533339 0.47158830814649 no 1560 0.468404717643854 2268 6748079
SGTC_3142 9086498 49.47 µM 0.0787297832252616 0.471798813185295 no 1561 0.468623777706041 2281 25236367
SGTC_1300 1094-0077 113 µM 0.0784765451763805 0.47189559523005 no 1562 0.468724493455416 2216 5532636
SGTC_2124 5246320 200 µM 0.0780047960741724 0.472075891842175 no 1563 0.468912118952152 2203 579342
SGTC_2543 pimpinellin 60.67 µM 0.0778471354329523 0.472136149046797 no 1564 0.468974825766306 2162 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_14 0354-0009 295 µM 0.077613741636643 0.472225352301134 no 1565 0.469067655555623 2258 1713507
SGTC_2024 5144227 134 µM 0.0768118627849044 0.472531841486095 no 1566 0.469386606742067 2235 3475211
SGTC_809 3998-0021 90 µM 0.0767345549489431 0.472561390472435 no 1567 0.469417357348793 2276 715485
SGTC_2620 irigenin 100 µM 0.075713843659179 0.472951545925827 no 1568 0.46982338098108 2234 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3279 9140807 49.47 µM 0.074834953718644 0.473287512564606 no 1569 0.470173015367137 2248 45595718
SGTC_599 1935-0052 86.5 µM 0.0741115000941592 0.473564076002606 no 1570 0.470460832337783 2276 9557311
SGTC_2404 5161160 200 µM 0.073914005578109 0.473639576858969 no 1571 0.470539405747113 2231 2831543
SGTC_1555 citronellol 128 µM 0.0735969055915822 0.473760804080743 no 1572 0.470665566721755 2280 8842 A terpine precursor.
SGTC_540 1187-0821 17.3 µM 0.0732436932162163 0.47389583991731 no 1573 0.470806098788726 2143 847520
SGTC_2043 5101342 149 µM 0.0729950434551721 0.47399090245355 no 1574 0.47090503087004 2208 678451
SGTC_791 1348-1292 225 µM 0.0727388097495737 0.474088865995056 no 1575 0.471006982308879 2247 5437054
SGTC_3217 9129673 49.47 µM 0.0721800677760344 0.474302490243142 no 1576 0.471229303701514 2237 17248312
SGTC_2569 tetrandrine 100 µM 0.072089226177537 0.474337222481239 no 1577 0.471265450091326 2147 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0715575781971425 0.47454049586113 no 1578 0.471477000589887 2237 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1673 st016611 27.3 µM 0.0695771746379446 0.475297752780022 no 1579 0.472265102451557 2248 5226799
SGTC_3318 9139014 38.6185 µM 0.0688842290179 0.475562739114665 no 1580 0.472540886059111 2260 16643984
SGTC_638 3970-0837 4.09 µM 0.0686264554956251 0.475661315935939 no 1581 0.472643480032721 2219 4118451 YLR208W SEC13
SGTC_3054 9094397 49.47 µM 0.0678732525515688 0.475949361604957 no 1582 0.47294326550531 2264 2598354
SGTC_504 lovastatin 124 µM 0.0677897437690749 0.475981298453287 no 1583 0.472976504134067 2143 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_23 0213-0011 39.996 µM 0.0673593441042475 0.476145901652792 no 1584 0.473147817174671 2270 627608
SGTC_3138 9097216 49.47 µM 0.0663512979352939 0.47653143740983 no 1585 0.473549071662012 2321 25237486
SGTC_2871 9038510 12.99 µM 0.0650606163778094 0.477025101478207 no 1586 0.474062868771163 2304 4945164
SGTC_3041 9091929 49.47 µM 0.0644013430457914 0.477277276133511 no 1587 0.474325330326451 2256 25236887
SGTC_1987 st072290 61.9 µM 0.064193353380288 0.47735683489555 no 1588 0.474408134857598 2177 54697379
SGTC_1719 st032227 49.2 µM 0.0634902754376933 0.477625778049074 no 1589 0.474688051349286 2253 3125804
SGTC_1997 st073024 93.8 µM 0.0626412550627841 0.47795056104222 no 1590 0.475026088558632 2302 686268
SGTC_1298 1079-1278 263 µM 0.0624885868892657 0.478008964058201 no 1591 0.47508687526056 2271 2840950
SGTC_1091 telmisartan 47.6 µM 0.0622507837134989 0.478099936301476 no 1592 0.475181560660308 2273 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1420 4'-methoxyflavone 42 µM 0.0620454163292404 0.478178501064055 no 1593 0.475263332323301 2298 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_142 0335-0849 62.6745 µM 0.0617274073360759 0.478300159352368 no 1594 0.475389956841977 2285 3889043 YPR107C YTH1
SGTC_823 0417-1665 178 µM 0.0613751213874831 0.478434933075722 no 1595 0.475530232627619 2215 3429856
SGTC_3116 9124943 49.47 µM 0.0613726949321664 0.478435861371153 no 1596 0.475531198821812 2242 41905195 YPL160W CDC60
SGTC_3039 9090270 49.47 µM 0.060658102817835 0.478709249835899 no 1597 0.475815749655985 2308 17173750
SGTC_1556 plumbagin 1.48 µM 0.0604103616988107 0.478804032913701 no 1598 0.475914403144428 2294 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3134 9127454 49.47 µM 0.0592051765078883 0.479265140759327 no 1599 0.476394343310156 2308 24262820
SGTC_1426 4048-4480 71.7 µM 0.0588310850617066 0.479408275058512 no 1600 0.476543324516659 2304 14224343
SGTC_1734 st037168 69.4 µM 0.0581044742754025 0.479686297341971 no 1601 0.476832705230129 2115 708907
SGTC_3128 9127691 49.47 µM 0.0569394510637466 0.480132089458189 no 1602 0.477296713934887 2246 41316314
SGTC_1746 st038117 42 µM 0.055400876696121 0.480720857625832 no 1603 0.477909548704756 2242 2898218
SGTC_2937 9044753 11.33 µM 0.0550673339847915 0.480848500421649 no 1604 0.47804241017205 2310 6465530 YGL099W LSG1
SGTC_1622 st003707 19.4 µM 0.0545398575567587 0.48105036332809 no 1605 0.478252527045541 2238 10140899
SGTC_1514 1189-1591 158 µM 0.0525839945215932 0.481798905505162 no 1606 0.479031684923746 2294 767698 YMR146C TIF34
SGTC_2074 5212007 75.395 µM 0.0525570812736043 0.481809206118309 no 1607 0.479042406930033 2328 758611
SGTC_1193 1488-0126 41.5 µM 0.0496609438653596 0.482917725708005 no 1608 0.480196290157548 2323 1384710
SGTC_1516 st013856 110 µM 0.0486069865770394 0.483321169455615 no 1609 0.480616251032566 2250 5281404 A mutagen and neurotoxin.
SGTC_3242 9133940 49.47 µM 0.0475730708883268 0.483716958086489 no 1610 0.481028247019852 2309 17248444
SGTC_2768 sulfasalazine 50.2 µM 0.046544995370507 0.484110526977848 no 1611 0.481437935903299 2319 5384001 An antioxidant and salicylic acid derivative.
SGTC_10 0279-0212 42.575 µM 0.0463736681223263 0.484176116160532 no 1612 0.481506211860737 2332 39851 YBR002C RER2
SGTC_1425 4048-4433 7.33 µM 0.0449623456432024 0.484716428644857 no 1613 0.482068661203548 2329 23734946
SGTC_3089 9117425 49.47 µM 0.0446329911719434 0.484842523202675 no 1614 0.4821999228507 2187 9401657
SGTC_538 2922-0838 53.3 µM 0.0441534549288569 0.485026118104962 no 1615 0.482391041713868 2325 777039
SGTC_3338 9144300 39.5675 µM 0.0439216677626709 0.48511486111364 no 1616 0.482483421794205 2285 4901274
SGTC_958 1222-0007 33 µM 0.043305886843447 0.485350625153766 no 1617 0.482728849302051 2308 7312461
SGTC_2407 paclitaxel 400 µM 0.0417946109074211 0.485929268907905 no 1618 0.483331215566926 2227 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1280 0880-0253 10.1 µM 0.0405348489452249 0.486411634616304 no 1619 0.483833362210895 2297 6836607
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0397388075291319 0.486716450972946 no 1620 0.484150681082592 2330 688662
SGTC_4 0960-0234 25.671 µM 0.0392102490587493 0.486918848342673 no 1621 0.484361381177187 2245 6821112
SGTC_1842 st055362 61.2 µM 0.0390403784788231 0.486983896468807 no 1622 0.484429097883759 2282 676032
SGTC_1799 st045822 46.1415 µM 0.0388639783404469 0.487051445309293 no 1623 0.484499417989524 2340 3674992
SGTC_3110 9122132 49.47 µM 0.0381124079330504 0.487339248030128 no 1624 0.484799029199298 2317 918317
SGTC_348 k064-0012 10.7 µM 0.0366375544737675 0.487904040275039 no 1625 0.485386999740048 2334 5066323
SGTC_3052 9092717 49.47 µM 0.0356406466326501 0.488285817991354 no 1626 0.485784448785225 2309 25237534
SGTC_747 3448-8087 38.7 µM 0.0347765112583067 0.48861675760977 no 1627 0.486128975300016 2320 5168703
SGTC_2215 7188065 200 µM 0.0341113076133622 0.488871517304616 no 1628 0.486394195780981 2342 940217
SGTC_2300 7976697 71.57 µM 0.0334666828605345 0.489118400028331 no 1629 0.486651217083422 2312 2236109
SGTC_2449 5812982 45.77 µM 0.0334567963728072 0.489122186454604 no 1630 0.486655159013897 2358 776185
SGTC_2740 felodipine 17.08 µM 0.0329828159626888 0.48930371737203 no 1631 0.486844145530476 2356 3333 L-type calcium channel blocker
SGTC_2536 dehydroabietamide 32.04 µM 0.0325999886018456 0.489450338979329 no 1632 0.486996789460632 2346 3983547
SGTC_385 1494-0393 12.4 µM 0.0319670251320647 0.489692765003127 no 1633 0.487249173791585 2327 3090647
SGTC_2882 9058044 58.44 µM 0.0279275241056075 0.491239986284627 no 1634 0.488859977969886 2329 18076804
SGTC_495 decylubiquinone 155 µM 0.0276708593577614 0.491338299452554 no 1635 0.488962332832101 2271 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1706 st031321 9.9705 µM 0.0268914439987771 0.491636850831786 no 1636 0.489273158875518 2352 6103185
SGTC_1213 1315-0166 115 µM 0.0265472607326445 0.49176869011063 no 1637 0.489410419126482 2268 768401
SGTC_997 3996-0078 137 µM 0.0263753846389306 0.491834527525322 no 1638 0.489478963765436 2334 735687
SGTC_855 0428-0020 25 µM 0.0263227050793642 0.491854706560134 no 1639 0.489499972574876 2312 6812414
SGTC_402 epigallocatechin gallate 10 µM 0.0260258448614741 0.491968419984687 no 1640 0.48961836210588 2299 65064 An antioxidant.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0259291895924547 0.492005444290831 no 1641 0.489656908970789 2336 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_330 1488-0319 80.1 µM 0.0251968920932983 0.492285956891564 no 1642 0.489948957960432 2299 6846614
SGTC_853 0419-0306 21 µM 0.0236529585217678 0.492877385720695 no 1643 0.490564714578599 2344 762713
SGTC_3198 9112019 49.47 µM 0.0222399664539035 0.493418669034587 no 1644 0.49112826842308 2360 45595555
SGTC_1730 st033808 45.1 µM 0.0222343900056071 0.493420805262617 no 1645 0.491130492554105 2278 1045166
SGTC_2557 derrustone 83.84 µM 0.0220951077451496 0.493474161627356 no 1646 0.491186044489321 2259 629853 An antioxidant.
SGTC_2572 astragaloside iv 100 µM 0.022044894752878 0.493493397291082 no 1647 0.491206071696892 2320 45006101 An anti-inflammatory agent.
SGTC_656 4090-1979 187 µM 0.0219856077933138 0.49351610904244 no 1648 0.491229718040689 2367 22330961
SGTC_1616 st002734 56.1 µM 0.0219015198722297 0.493548321625205 no 1649 0.491263256192053 2319 4026101
SGTC_501 nsc-95397 161 µM 0.0218346998599221 0.493573919210119 no 1650 0.49128990714694 2345 262093
SGTC_2421 5690543 90.72 µM 0.0217793659380327 0.493595116693536 no 1651 0.491311976939687 2319 3397993
SGTC_1304 1165-0502 251 µM 0.0204339975330524 0.494110509847056 no 1652 0.491848581698809 2359 767425
SGTC_1711 st032263 62.8 µM 0.0192132047102164 0.494578188244685 no 1653 0.492335511856089 2324 3958979
SGTC_787 4152-0075 138 µM 0.0191291980076051 0.494610370989244 no 1654 0.492369019523402 2331 9566539
SGTC_424 splitomicin 100 mM 0.0185973641680177 0.494814115925437 no 1655 0.492581152781319 2248 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2663 amphotericin b 100 µM 0.0169363141606072 0.495450470753455 no 1656 0.493243711202941 2370 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_613 3914-0030 117 µM 0.0158989020402071 0.495847913416038 no 1657 0.493657522968689 2366 1145395
SGTC_3030 9087619 49.47 µM 0.0151914362049266 0.496118952838667 no 1658 0.493939726896766 2373 25236973
SGTC_2372 9071633 200 µM 0.0148420090499921 0.496252823624663 no 1659 0.494079112445338 2381 21321366
SGTC_2690 usnic acid 100 µM 0.0147053120802881 0.496305194400471 no 1660 0.494133640695092 2367 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2873 9040596 71.43 µM 0.0145623617988607 0.496359960987216 no 1661 0.494190663500279 2279 6463863
SGTC_866 0495-0101 262 µM 0.0142844174424206 0.496466446203566 no 1662 0.4943015357221 2363 635694
SGTC_2581 avocatin a 64 µM 0.0134261455605795 0.496795266333599 no 1663 0.494643903789764 2371 6710728 A skin care supplement.
SGTC_1185 1319-0113 81.3 µM 0.0128606948305255 0.49701190236648 no 1664 0.494869466506698 2367 4672763
SGTC_2565 isoliquiritigenin 100 µM 0.0124503824059072 0.497169102216453 no 1665 0.495033144371838 2346 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3207 9114163 49.47 µM 0.0121313615251334 0.497291326542919 no 1666 0.495160405676209 2379 849233
SGTC_1675 st018485 24.5 µM 0.0120922838551169 0.49730629812577 no 1667 0.495175994267561 2319 3323024
SGTC_1205 4161-2785 76 µM 0.010787140667088 0.497806331505805 no 1668 0.495696636961701 2352 3498106
SGTC_620 0109-0052 432 µM 0.0103658516516322 0.497967738761348 no 1669 0.495864697560909 2382 493037
SGTC_1506 4226-2149 212 µM 0.00937852334523596 0.498346012288514 no 1670 0.496258565357308 2334 991114
SGTC_1107 amlodipine 47 µM 0.00935819020032272 0.498353802510851 no 1671 0.496266676752547 2382 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1852 st056254 31.4 µM 0.00901475081085046 0.498485384275248 no 1672 0.496403683463884 2335 442583
SGTC_3210 9128157 49.47 µM 0.00756061987003429 0.499042506402262 no 1673 0.496983777803865 2354 17590849
SGTC_2783 7738165 71.43 µM 0.00752813849216416 0.499054951038919 no 1674 0.496996735630053 2378 17201110
SGTC_960 1222-0186 7.7 µM 0.00724031247241558 0.499165226271411 no 1675 0.497111558467831 2389 3126296
SGTC_898 1000-0849 28.3 µM 0.00716665102723843 0.499193448306537 no 1676 0.497140944370312 2384 6751807
SGTC_797 k781-0471 270 µM 0.00550281062377943 0.499830919122656 no 1677 0.497804707260387 2368 23738129
SGTC_2471 5466956 24.79 µM 0.00515173861171385 0.499965426221024 no 1678 0.497944762741355 2359 724419
SGTC_1994 st072947 40.9 µM 0.00497125912982099 0.499965426221024 no 1679 0.498016762715048 2362 5286565 YDL195W SEC31
SGTC_3235 9132602 49.47 µM 0.00394648136887206 0.49957280062042 no 1680 0.498425585809984 2380 4912240
SGTC_2881 9058953 51.95 µM 0.00371334037325061 0.499483476786781 no 1681 0.49851859492808 2391 17122249
SGTC_1238 0333-0287 48.8 µM 0.00290432036055428 0.499173515360466 no 1682 0.498841345441234 2397 7226
SGTC_1424 4048-1941 275 µM 0.00267059377847513 0.499083967320685 no 1683 0.498934588494421 2399 X1424
SGTC_1070 indatraline 8.81 µM 0.00186488703899641 0.498775275988981 no 1684 0.499256018143209 2397 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2063 5246145 200 µM 0.00128651226606953 0.498553683051393 no 1685 0.499486756004389 2403 711240
SGTC_1158 4092-0494 91.8 µM 0.000984951067018152 0.498438145971929 no 1686 0.499607061438773 2399 1148199
SGTC_429 1112-0049 25.5 µM 0.000255731393952252 0.498158760750599 no 1687 0.499897977935638 2402 2836170
SGTC_3270 9137563 49.47 µM 0.000164241524780525 0.49812370838729 no 1688 0.499934477111862 2404 17015724
SGTC_950 1165-0508 94.1 µM -0.000198313018595809 0.497984803605621 no 1689 0.499920884552647 2400 6148369
SGTC_1457 k015-0032 57.3 µM -0.00135508491875509 0.497541613665761 no 1690 0.499459399497821 2406 4302660
SGTC_3060 1327-0027 12.5 µM -0.00234263395885419 0.497163259863285 no 1691 0.499065425121123 2404 16000455 YPR107C YTH1
SGTC_2294 7971431 200 µM -0.00277308762969315 0.496998343481641 no 1692 0.498893699515169 2413 5741572
SGTC_1142 3253-1408 9.78 µM -0.00296460620203674 0.496924968617272 no 1693 0.498817294973712 2398 256655
SGTC_3147 9097027 49.47 µM -0.00373123732664625 0.496631256890799 no 1694 0.498511455126143 2416 25236841
SGTC_2299 7976368 114.88 µM -0.00539242649224334 0.495994828553721 no 1695 0.497848743504093 2419 2979718
SGTC_80 0159-0065 512.242 µM -0.00547014701055142 0.495965052807811 no 1696 0.497817737960611 2420 1548079
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.00584016165504433 0.495823295674716 no 1697 0.49767012583579 2414 688667
SGTC_2947 9072639 7.68 µM -0.00748095082244693 0.495194695890352 no 1698 0.497015560256523 2424 16488146
SGTC_1948 st076329 66.6 µM -0.00860618010949992 0.49476361812595 no 1699 0.496566673263945 2417 24208413
SGTC_1461 k072-0203 53.8 µM -0.00874675181080607 0.494709765223627 no 1700 0.496510595379753 2405 5418714
SGTC_2434 5670830 169.91 µM -0.00913346981693278 0.494561614376225 no 1701 0.496356323382741 2433 1549830
SGTC_68 0986-0284 82.829 µM -0.00932119763354633 0.494489696517276 no 1702 0.496281434007843 2488 423278 YIL048W NEO1
SGTC_374 0880-0231 82.3 µM -0.0105361880481619 0.494024242443768 no 1703 0.495796746881542 2424 6833587
SGTC_1003 4049-0218 100 µM -0.0107606513433282 0.493938253044196 no 1704 0.495707204059612 2439 295161
SGTC_2248 tofa 1.1 µM -0.0112088341369103 0.493766560031974 no 1705 0.495528415782431 2426 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2259 7964009 200 µM -0.0116209338170872 0.493608691010521 no 1706 0.495364022507967 2476 313134
SGTC_2980 9014342 25.29 µM -0.0118670037145921 0.493514425909742 no 1707 0.495265861591616 2484 2996599
SGTC_1686 st019653 115.5 µM -0.0128889349705594 0.493122945742262 no 1708 0.494858201254542 2433 97252
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0138133124178445 0.492768842062552 no 1709 0.494489460886809 2431 6710655
SGTC_1780 st038448 24.544 µM -0.0141791467070323 0.492628702525512 no 1710 0.494343528416425 2482 728868 YDL195W SEC31
SGTC_2709 st078560 56 µM -0.0155627561564789 0.492098693910819 no 1711 0.493791609182015 2432 17250903
SGTC_2496 diffractaic acid 79.83 µM -0.0158351052767473 0.491994368844664 no 1712 0.49368297099136 2429 94870 An apoptosis inducer which activates caspases.
SGTC_932 2857-0803 154 µM -0.0165424982214525 0.491723400045178 no 1713 0.493400799020599 2508 674898
SGTC_2738 aclarubicin 5.55 µM -0.0165687013375398 0.491713362942583 no 1714 0.493390346922209 2438 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2170 morpholine 200 µM -0.0166329366709545 0.491688757622833 no 1715 0.4933647242627 2446 121171 Reacts with secondary amines.
SGTC_1376 2910-0861 41.3 µM -0.0169610590020328 0.491563070985526 no 1716 0.493233840857244 2439 1112859
SGTC_2277 7947813 106.88 µM -0.017752465072992 0.491259927860174 no 1717 0.492918163076491 2530 1246798
SGTC_25 0118-0223 35.662 µM -0.0186075570882224 0.490932395912815 no 1718 0.492577087098018 2437 5333628
SGTC_3201 9113999 49.47 µM -0.0189211063271355 0.490812296448677 no 1719 0.492452021069961 2470 16649224
SGTC_352 k048-0007 5.11 µM -0.0190298070677033 0.490770660755519 no 1720 0.492408663555188 2442 6811911
SGTC_1173 0443-0020 122 µM -0.0193221211819814 0.490658696050003 no 1721 0.49229206853525 2458 5331295
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.0194594240014083 0.49060610537824 no 1722 0.492237302932363 2438 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1591 genipin 88.4 µM -0.0196075183744106 0.490549381434375 no 1723 0.492178233095852 2483 442424 A DNA cross-linking agent.
SGTC_2484 5809818 12.04 µM -0.0207991484810183 0.490092963589561 no 1724 0.491702938503351 2468 2870548
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0268519577989376 0.487774831016068 no 1725 0.489288905903726 2475 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1847 st056231 15 µM -0.0270016454325512 0.487717507872336 no 1726 0.489229210822841 2454 5393180
SGTC_874 0599-0792 117 µM -0.0273678800108718 0.487577258765875 no 1727 0.48908315834301 2458 765305
SGTC_2531 methyl deoxycholate 70.07 µM -0.0275221140012241 0.487518195497106 no 1728 0.48902165105211 2466 16667744 Haematoxylin.
SGTC_536 3852-0578 10.6 µM -0.027990113224966 0.48733897881081 no 1729 0.48883501828123 2448 2869208
SGTC_600 1495-0418 41.6 µM -0.0282244649470332 0.487249236588233 no 1730 0.488741562394314 2462 5377768
SGTC_1697 st025554 27.742 µM -0.0286973540462425 0.487068151266528 no 1731 0.488552983332647 2453 1269519
SGTC_3254 9136651 49.47 µM -0.0290951904719303 0.486915808230055 no 1732 0.488394335811539 2471 16454030
SGTC_1666 st014829 29 µM -0.0294685108691942 0.486772854823668 no 1733 0.488245466357809 2448 3858230
SGTC_45 0kpi-0036 14.9 µM -0.0296813366035976 0.48669135946366 no 1734 0.488160598298307 2473 2795021
SGTC_1751 st044839 27.194 µM -0.0300276686494497 0.486558742975061 no 1735 0.488022493362431 2454 5291326
SGTC_3013 9080133 71.4286 µM -0.0307436269677381 0.486284594967485 no 1736 0.487736999151413 2491 17050193
SGTC_3334 9142812 21.919 µM -0.0309747322618728 0.486196103685199 no 1737 0.487644845367527 2527 45283678
SGTC_2335 9018011 154.17 µM -0.0331928474642493 0.485346812354624 no 1738 0.486760400938973 2510 6458208
SGTC_116 0155-0182 31.788 µM -0.0334116140415081 0.485263052634099 no 1739 0.486673174084326 2472 771486
SGTC_590 k048-0076 22.4 µM -0.0334793396154144 0.485237122501546 no 1740 0.486646170596709 2478 6832814
SGTC_2078 5212016 200 µM -0.0338580855416618 0.485092112967276 no 1741 0.486495158450703 2457 1899708
SGTC_173 1273-0061 2.693 µM -0.0340381329130019 0.485023179357029 no 1742 0.486423371320223 2505 2847414 YPL266W DIM1
SGTC_894 0960-0238 55.9 µM -0.0344556497577142 0.484863329021537 no 1743 0.486256903848576 2449 6741907 YDL195W SEC31
SGTC_2965 9082772 38.63 µM -0.0346506130331257 0.484788686289914 no 1744 0.486179171172121 2485 16459634
SGTC_1268 0828-0275 2.46 µM -0.0347949900409097 0.484733411124483 no 1745 0.486121607791215 2522 745337
SGTC_2720 fluspirilene 36.88 µM -0.0350749619150846 0.484626223899451 no 1746 0.486009983310626 2500 3396 An atypical antipsychotic.
SGTC_1289 0976-0073 69.1 µM -0.0354564501388743 0.484480172932137 no 1747 0.485857886138362 2542 3391136
SGTC_1988 st071872 53.4 µM -0.0360787799667197 0.484241921370204 no 1748 0.485609771221923 2455 16414116
SGTC_582 0987-0078 156 µM -0.0367927951535821 0.483968576096076 no 1749 0.485325109397571 2471 1625765
SGTC_2857 9024691 58.44 µM -0.03695552612564 0.483906279111982 no 1750 0.485260233253721 2526 16478292
SGTC_3145 9085516 49.47 µM -0.0370377252224837 0.483874811644683 no 1751 0.485227462993417 2528 25236195
SGTC_846 0335-0850 148 µM -0.0374298409416708 0.483724703247584 no 1752 0.485071139852442 2474 6819598
SGTC_1491 4138-0063 26.5 µM -0.0398303607859796 0.482805795537515 no 1753 0.484114185511806 2478 23883227
SGTC_194 1486-1323 56.904 µM -0.0419914093542933 0.481978634283188 no 1754 0.483252773210209 2501 5178754
SGTC_1214 0358-0031 63.7 µM -0.0421452147196853 0.481919766777141 no 1755 0.483191468018283 2568 4301366
SGTC_1571 st070080 73.4 µM -0.0429537370278906 0.481610319248822 no 1756 0.482869206146514 2520 4315245
SGTC_1610 st001799 48.1 µM -0.0446502887229162 0.480961030510509 no 1757 0.482193028998989 2486 621897
SGTC_1958 st076513 41.9 µM -0.0455587309116328 0.480613380482213 no 1758 0.481830981478198 2488 732122 YGL099W LSG1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0463017333448983 0.480329053231374 no 1759 0.481534878891678 2476 368090
SGTC_749 1000-0129 128 µM -0.0468489198183785 0.480119665926139 no 1760 0.481316819716808 2533 708470
SGTC_2324 6149169 200 µM -0.0487543449114391 0.479390575905167 no 1761 0.48055753317889 2519 2888231
SGTC_1547 harmine 94.2 µM -0.049318237356275 0.479174821756121 no 1762 0.480332842946807 2481 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2497 7-hydroxyflavone 100 µM -0.049396210409804 0.479144988514011 no 1763 0.48030177406609 2521 5281894
SGTC_1483 3453-0561 55.9 µM -0.0499103713640999 0.478948268508431 no 1764 0.480096906226103 2563 4546991
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.049918720579944 0.478945074107759 no 1765 0.480093579517661 2538 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_487 nimodipine 119 µM -0.0502521333329788 0.478817511867725 no 1766 0.479960733803863 2491 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1579 chlormadinone acetate 49.4 µM -0.0510593145478996 0.478508696926765 no 1767 0.479639127983462 2493 45114258 A steroidal progestin.
SGTC_1749 st037932 54.2 µM -0.0512824398730202 0.478423334926386 no 1768 0.479550230321277 2573 594497
SGTC_912 3474-0017 2.18 µM -0.0523720675825772 0.478006485731571 no 1769 0.479116115201722 2558 3360550
SGTC_3276 9139060 49.47 µM -0.0534020600268382 0.477612472783342 no 1770 0.478705781946365 2484 4870619
SGTC_2332 7982454 138.89 µM -0.0537634693734151 0.477474224545208 no 1771 0.47856180731039 2480 2981748
SGTC_2108 5365811 200 µM -0.0538260926291027 0.47745026983726 no 1772 0.4785368603688 2556 780283
SGTC_2495 cafestol 54.53 µM -0.0541355633899018 0.477331891982284 no 1773 0.478413579145586 2672 16667697 An anti-infammatory.
SGTC_1258 0671-0043 57.1 µM -0.0548647940636786 0.477052956714909 no 1774 0.478123089940202 2535 4298767
SGTC_1559 coumarin 343 70.1 µM -0.0551102833620049 0.476959058054305 no 1775 0.478025301829271 2552 108770 A hepatotoxic, DNA x-linker.
SGTC_2056 5235370 200 µM -0.0552045060103668 0.476923018613033 no 1776 0.477987769567445 2531 5511916
SGTC_2023 5144124 124 µM -0.0553637574431298 0.476862106589089 no 1777 0.477924334451366 2524 2830192
SGTC_1786 berberine 21.6 µM -0.055881336878926 0.47666414155563 no 1778 0.477718169303913 2499 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3112 9123419 49.47 µM -0.0563793573722834 0.476473662909993 no 1779 0.477519800612691 2506 17015854
SGTC_1187 1391-0724 117 µM -0.0566029368170364 0.476388151889907 no 1780 0.477430747528076 2529 6997986
SGTC_491 tetrandrine 80.3 µM -0.0568413450317888 0.476296970601686 no 1781 0.47733578929375 2533 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1132 3456-3614 2.5 µM -0.0569584088664276 0.476252198977467 no 1782 0.477289163120115 2581 3125502
SGTC_3104 9120930 49.47 µM -0.0599473520266547 0.475109166461851 no 1783 0.476098783109243 2569 17014836
SGTC_2920 7982904 15.77 µM -0.0604599231619673 0.474913169173109 no 1784 0.475894667056336 2569 6456808
SGTC_1444 4112-3581 28 µM -0.0634646228903016 0.473764353754507 no 1785 0.474698264637655 2509 2877249
SGTC_1039 k821-0043 94 µM -0.0638055046898035 0.473634034774958 no 1786 0.474562547542093 2497 15992768
SGTC_3342 9147791 14.508 µM -0.0651463775570744 0.473121447108959 no 1787 0.47402872744089 2514 1838168
SGTC_1820 st053765 18.6 µM -0.0652144318200754 0.473095432566456 no 1788 0.474001635329408 2570 3690829
SGTC_2539 epi(13)torulosol 80 µM -0.0676693987922261 0.472157070162875 no 1789 0.473024404840112 2591 6708597
SGTC_2192 5915882 198.485 µM -0.0688961821149789 0.471688214160244 no 1790 0.472536128765435 2523 2876149
SGTC_60 0986-0278 202 µM -0.0690143015083237 0.471643072970257 no 1791 0.472489117842646 2519 3110598
SGTC_119 0121-0043 24.815 µM -0.0695553240736082 0.471436317324411 no 1792 0.472273798497945 2525 1092378
SGTC_2166 5933061 31.504 µM -0.0702719806900171 0.471162453730244 no 1793 0.471988591765347 2794 2877375
SGTC_1692 fluoroquinolonic acid 71 µM -0.0726912835293583 0.470238041348665 no 1794 0.47102589246788 2644 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_313 3474-0040 5.03 µM -0.0757864626163011 0.469055612055357 no 1795 0.469794493207998 2536 1043375 YIL048W NEO1
SGTC_1363 1636-0063 10.4 µM -0.0760704267205099 0.468947144772623 no 1796 0.469681534003019 2546 6072185
SGTC_169 k015-0017 16.025 µM -0.0783324321695566 0.468083197460225 no 1797 0.468781809786621 2578 1840002
SGTC_2930 9013230 14.89 µM -0.0784099982409899 0.468053574621626 no 1798 0.468750960286378 2585 2995857
SGTC_953 1188-0045 9.7 µM -0.0785056773189874 0.468017034586403 no 1799 0.468712907157787 2630 6144426
SGTC_3162 9099653 49.47 µM -0.0789576854837284 0.467844415394077 no 1800 0.468533140014902 2546 25237511
SGTC_729 4092-0585 94.1 µM -0.0803201122258798 0.467324149546145 no 1801 0.467991331323791 2551 2169061
SGTC_1922 5578187 25 µM -0.0804121077326955 0.467289021497334 no 1802 0.467954748755617 2652 1350412
SGTC_1884 5633444 25 µM -0.0824041912041613 0.466528416799946 no 1803 0.467162651644176 2656 5724239
SGTC_1037 k284-1091 78.7 µM -0.0831315685725427 0.466250724494097 no 1804 0.466873462311791 2538 3334711
SGTC_570 0987-0065 62.6 µM -0.0831760684427472 0.466233736222012 no 1805 0.466855770702773 2551 3104428
SGTC_2713 st079149 53.4 µM -0.0832288913658735 0.466213570620799 no 1806 0.466834770220834 2610 3103253
SGTC_2834 9001755 58.44 µM -0.0842751804569053 0.465814158782235 no 1807 0.466418822657 2693 2989575
SGTC_2757 clomiphene 4.22 µM -0.0843296128993704 0.465793380605466 no 1808 0.466397184281873 2609 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2988 9073640 71.4286 µM -0.0843510506532454 0.465785197323101 no 1809 0.466388662219378 2650 9102229
SGTC_185 k048-0037 25.491 µM -0.0853394584569455 0.465407915160146 no 1810 0.465995761311552 2540 6827589
SGTC_1767 st044992 70.3 µM -0.0862505983374306 0.465060154235712 no 1811 0.465633604437905 2592 9600693
SGTC_2919 7978188 46.38 µM -0.0884391476691006 0.464224945331362 no 1812 0.464763823918724 2584 2980291
SGTC_695 3505-6186 243 µM -0.0895009987915914 0.463819771131988 no 1813 0.464341879924881 2650 1819379
SGTC_2148 5546263 113.568 µM -0.0896894120367096 0.463747881547058 no 1814 0.464267015000781 2572 792097
SGTC_2822 7994718 71.43 µM -0.0901885509411065 0.463557439471376 no 1815 0.464068691137249 2556 1018011
SGTC_2377 9073351 62.6 µM -0.0910316428159364 0.463235784140816 no 1816 0.46373372404992 2552 7337946 YHR072W ERG7
SGTC_558 k064-0027 21.3 µM -0.0923736554520692 0.462723830862168 no 1817 0.463200584911474 2649 5088526
SGTC_162 k030-0015 37.8 µM -0.0926178203356326 0.462630693037672 no 1818 0.463103593010204 2614 1809920 YMR134W ERG29
SGTC_2833 9001315 45.46 µM -0.0926357692657246 0.462623846416022 no 1819 0.463096463075236 2634 2989378
SGTC_3082 9117008 49.47 µM -0.0928754235954506 0.462532431303452 no 1820 0.463001265234861 2621 41448529
SGTC_653 0203-0016 55.2 µM -0.0931386785233277 0.462432016125286 no 1821 0.462896694976074 2642 295302
SGTC_946 3434-1334 87.4 µM -0.0949154812015877 0.461754340717526 no 1822 0.462190979907479 2681 4047976
SGTC_1165 k072-0275 30.3 µM -0.0950297115250908 0.461710776865188 no 1823 0.462145613660906 2578 6153523 YGL055W OLE1
SGTC_2844 9010103 25.97 µM -0.0954334348587681 0.461556813169074 no 1824 0.461985280042484 2732 2480525
SGTC_829 1635-0120 117 µM -0.0958134030118148 0.461411913997167 no 1825 0.461834386136099 2683 285054
SGTC_2515 chrysin 20.77 µM -0.096713509738781 0.46106868275866 no 1826 0.46147695545345 2670 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1175 0741-0056 27.6 µM -0.0988990678865346 0.460235400749116 no 1827 0.460609204498951 2677 765927
SGTC_2171 5739187 198.077 µM -0.0991628933928537 0.460134824430484 no 1828 0.460504468192939 2563 2262761
SGTC_211 3455-0679 143.504 µM -0.0998957500875052 0.459855456095952 no 1829 0.460213545206941 2627 748649
SGTC_19 0279-0214 38.434 µM -0.10005756293959 0.459793774960534 no 1830 0.460149313033238 2591 3566274 YBR002C RER2
SGTC_48 0382-0018 55 µM -0.10214545026653 0.458997984454534 no 1831 0.459320612778665 2648 762596
SGTC_217 ketoconazole 989 nM -0.102592099280162 0.458827767062512 no 1832 0.459143356806674 2601 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2989 9073649 71.4286 µM -0.102820291769488 0.458740806095829 no 1833 0.459052800058344 2564 21367202
SGTC_1195 1502-0147 41.1 µM -0.103073261717208 0.458644405094086 no 1834 0.45895241301559 2589 817940
SGTC_2689 tacrolimus 100 µM -0.103423225945441 0.458511045824173 no 1835 0.458813539674016 2684 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1521 st012942 49.4 µM -0.103520247492976 0.458474075092329 no 1836 0.458775040323955 2835 24207259
SGTC_815 1582-0027 36.9 µM -0.10378265026072 0.458374086502955 no 1837 0.458670917598346 2662 3128206
SGTC_3323 9138564 53.9225 µM -0.103867078243898 0.458341915774984 no 1838 0.45863741675657 2620 43912313 YNL103W MET4
SGTC_386 1509-0011 3.07 µM -0.104096631460834 0.458254447410917 no 1839 0.458546332020737 2598 3107280
SGTC_670 4204-0025 119 µM -0.106970674815976 0.457159501820632 no 1840 0.45740612217198 2711 719039
SGTC_356 1634-0012 32.5 µM -0.107436801693709 0.456981948434242 no 1841 0.457221229962469 2597 735457
SGTC_2778 tioconazole 65.09 nM -0.108094858867665 0.456731301094967 no 1842 0.456960223144378 2580 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_298 1391-0729 10 µM -0.108903627911663 0.456423272713487 no 1843 0.456639464552512 2583 3237558
SGTC_2136 5328288 199.296 µM -0.109438713146971 0.456219494132899 no 1844 0.456427264741554 2634 262395
SGTC_2751 anetholtrithion 17.25 µM -0.111195133700629 0.455550670914754 no 1845 0.455730805224043 2704 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2387 9077560 195.08 µM -0.111379490821475 0.455480477275012 no 1846 0.455657711406841 2579 5303272
SGTC_2601 securinine 100 µM -0.111760775338293 0.455335308297888 no 1847 0.455506544680861 2635 442872 A GABA receptor antagonist.
SGTC_687 k029-0044 34.9 µM -0.111912313336847 0.455277613887995 no 1848 0.45544646665379 2627 5829338
SGTC_1850 st056238 17 µM -0.112455879718635 0.455070671967554 no 1849 0.455230975328342 2578 5393177
SGTC_1430 4049-0248 69.1 µM -0.116019485778416 0.453714271025193 no 1850 0.453818549331835 2678 22774488
SGTC_2176 5809774 33.9695 µM -0.116776211789898 0.453426310407599 no 1851 0.453518697499131 2713 2870539
SGTC_1226 3909-7979 35.4 µM -0.117129343372547 0.453291939904754 no 1852 0.453378778562838 2728 6615510
SGTC_1851 st056236 18.9 µM -0.117691641116475 0.453077990389229 no 1853 0.453155995085748 2617 5393171
SGTC_2064 5220758 200 µM -0.118277709167671 0.452855010970334 no 1854 0.452923809457835 2752 788518
SGTC_2605 digitonin 300 nM -0.120607368487057 0.451968800685831 no 1855 0.452001016121758 2615 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_359 0081-0058 15.9 µM -0.122054179193656 0.451418549158445 no 1856 0.451428055092428 2925 3494159
SGTC_1785 bathophenanthroline 24 µM -0.122743848156338 0.451156286813027 no 1857 0.451154970282439 2642 72812 An iron chelator.
SGTC_2359 9039622 200 µM -0.123637025716067 0.450816667385579 no 1858 0.450801337552552 2645 6463596
SGTC_2959 9079155 11 µM -0.125147545124215 0.450242393619986 no 1859 0.450203371787982 2776 16189457
SGTC_53 0973-0023 39.979 µM -0.125221087430089 0.450214436736769 no 1860 0.450174261642926 2614 674768
SGTC_3055 9094636 49.47 µM -0.125496571959919 0.450109714330349 no 1861 0.450065219382268 2752 25236176
SGTC_3061 glucosamine 200 µM -0.125617734905137 0.450063656672206 no 1862 0.45001726186984 2608 91431 and experimental redox chemotherapeutic
SGTC_2101 5377231 179.231 µM -0.125806591940668 0.449991867807808 no 1863 0.449942511811378 2727 2844213
SGTC_3350 9150499 3.57 µM -0.126935446826898 0.449562798536479 no 1864 0.449495745519844 2634 4910996 YPR165W RHO1
SGTC_2879 9041815 71.43 µM -0.12783735191698 0.44922003352888 no 1865 0.449138845002884 2633 4942971
SGTC_1472 k841-0093 193 µM -0.128150259853751 0.449101123103334 no 1866 0.449015031147538 2736 X1472
SGTC_686 1319-0111 510 µM -0.128289721410662 0.449048126772823 no 1867 0.448959849508679 2727 4562600
SGTC_1690 st023502 41.2 µM -0.128493997200316 0.448970502238665 no 1868 0.448879024193654 2706 24207482
SGTC_2040 5100729 123 µM -0.128812482848591 0.448849482004539 no 1869 0.448753013969443 2634 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_980 1473-0395 201 µM -0.129707263338946 0.448509503036158 no 1870 0.448399017902544 2641 768876
SGTC_1139 k015-0024 46.9 µM -0.129730772934176 0.448500570887039 no 1871 0.448389717510073 2618 2766652
SGTC_1905 st060207 84.5 µM -0.130366946503727 0.448258875367682 no 1872 0.448138058123795 2626 1948547
SGTC_1740 st038286 13.222 µM -0.13072886356431 0.448121384143085 no 1873 0.447994899230569 2810 716786
SGTC_284 0988-0104 32.6 µM -0.131054194847666 0.447997797065738 no 1874 0.447866217884512 2717 4666532
SGTC_2432 5630864 12.22 µM -0.131091629855367 0.447983576552206 no 1875 0.447851411215119 2757 5714970
SGTC_1221 2958-7315 257 µM -0.131759686569206 0.447729811729764 no 1876 0.447587186966918 2722 4562705
SGTC_1030 k029-0042 36.7 µM -0.131808779303712 0.44771116444138 no 1877 0.447567771131823 2683 6080581
SGTC_2355 9061122 103.12 µM -0.132931780631243 0.447284637448847 no 1878 0.447123666315875 2763 5302957
SGTC_3005 9076496 71.4286 µM -0.13348924899398 0.447072928070748 no 1879 0.446903233119055 2693 21368410
SGTC_364 0083-0097 67.7 µM -0.13372014488986 0.446985245307953 no 1880 0.446811937454675 2767 5207356
SGTC_1389 3405-0187 19 µM -0.133812048888966 0.44695034546662 no 1881 0.446775599625438 2693 799890
SGTC_1117 retinoic acid 1.10837 µM -0.137515063653446 0.445544498569184 no 1882 0.445311843391497 2776 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2055 5235184 200 µM -0.137740773777829 0.445458829835616 no 1883 0.445222646848497 2779 2836034
SGTC_1695 st026914 34.495 µM -0.138356821479304 0.445225020659224 no 1884 0.44497921010852 2635 3289191
SGTC_2070 5230947 200 µM -0.138671510889192 0.445105593631662 no 1885 0.444854865784044 2682 2835538
SGTC_1732 st034308 51.822 µM -0.139069015967521 0.444954744549852 no 1886 0.44469780597298 2610 830119
SGTC_1790 st045711 43.5 µM -0.140463374691852 0.444425662941303 no 1887 0.444146944159519 2678 585119
SGTC_1057 3448-5381 134 µM -0.14068671840404 0.444340925595919 no 1888 0.444058718954972 2779 5497911
SGTC_1254 0550-0035 264 µM -0.140727409876255 0.444325487390223 no 1889 0.444042645313248 2788 15121435
SGTC_1895 st058434 18.3 µM -0.140773376080621 0.444308048070754 no 1890 0.444024488196905 2731 5393175
SGTC_605 1315-0399 119 µM -0.142078399559604 0.443812974613015 no 1891 0.443509039865934 2770 24020461
SGTC_933 2914-0560 114 µM -0.14254174925136 0.44363721941291 no 1892 0.443326052443214 2824 463887
SGTC_658 3253-0951 102 µM -0.142761112078386 0.443554015803152 no 1893 0.443239425243316 2696 1184878
SGTC_2560 caryophyllene 100 µM -0.14407635930989 0.443055199102317 no 1894 0.442720086235065 2647 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_662 k832-1615 104 µM -0.144313183232084 0.442965391539404 no 1895 0.442626584282497 2731 5878478
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.144384870748141 0.442938207020714 no 1896 0.442598281510092 3011 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2970 9090938 41.86 µM -0.148169432079092 0.441503453523631 no 1897 0.441104527585963 2837 17217104
SGTC_50 0929-0078 56.389 µM -0.150263140853091 0.440710042407398 no 1898 0.44027850605189 2730 1377751
SGTC_845 0330-0138 4.51 µM -0.151712653380835 0.440160888712504 no 1899 0.439706788373757 2723 9039800
SGTC_355 1311-2252 105 µM -0.151918414492594 0.44008294458527 no 1900 0.439625642103556 2703 5338538
SGTC_2721 ifenprodil 61.44 µM -0.152011279859262 0.440047767124123 no 1901 0.439589019501838 2806 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2163 5671233 125 µM -0.152069488250276 0.440025717989107 no 1902 0.439566064569105 2746 701023
SGTC_1033 k072-0102 21.3 µM -0.152435254991942 0.439887171085383 no 1903 0.439421826256343 2695 5965931
SGTC_2507 purpurin 79.67 µM -0.153373020060086 0.439531993545081 no 1904 0.439052060005837 2667 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3290 9121031 71.43 µM -0.153543425740408 0.439467457788651 no 1905 0.438984873749918 2714 17014854
SGTC_646 4092-0839 27.3 µM -0.154556767842117 0.439083719834192 no 1906 0.438585377304511 2788 877796
SGTC_222 nsc-310342 10.666 µM -0.155075540503534 0.438887290283886 no 1907 0.438380882373018 2678 432556
SGTC_1455 4262-0120 131 µM -0.155543711167891 0.438710033735388 no 1908 0.438196348357061 2869 1529587
SGTC_198 3454-2873 16.191 µM -0.155840154238783 0.438597802224566 no 1909 0.438079509386064 2695 710957
SGTC_984 1492-0255 2.91 µM -0.157420528789561 0.437999565743903 no 1910 0.437456717763439 2823 1585198
SGTC_153 4077-0274 519.67 µM -0.157992982107694 0.437782903603009 no 1911 0.437231164364151 2780 3121976
SGTC_2821 7996764 71.43 µM -0.159811336306571 0.437094816900998 no 1912 0.436514846889504 2851 2987135
SGTC_3353 9151644 39.2805 µM -0.160388244655729 0.436876547623861 no 1913 0.436287624575416 2803 4909158
SGTC_657 3534-0529 86.7 µM -0.161001716096685 0.436644466035273 no 1914 0.436046024512803 2842 1049549
SGTC_2691 st077356 60.2 µM -0.161026441723645 0.436635112571883 no 1915 0.436036287455623 2851 2839272
SGTC_2401 5128683 200 µM -0.16188010151732 0.43631220316373 no 1916 0.435700136408445 2730 708373
SGTC_3200 9114385 49.47 µM -0.162256211262866 0.436169947560937 no 1917 0.435552048008163 2836 17018030 YLR208W SEC13
SGTC_2193 5925765 200 µM -0.162283517340577 0.436159619932463 no 1918 0.435541296941044 2794 877370
SGTC_2448 5185112 27.17 µM -0.162341944031236 0.436137522098861 no 1919 0.435518293091518 2830 5718189
SGTC_1019 4262-0212 3.4 µM -0.162906733298142 0.435923920779861 no 1920 0.435295934623872 2731 4677213
SGTC_1368 1852-0141 284 µM -0.164612766862573 0.435278818608784 no 1921 0.434624390903004 2833 2838987
SGTC_1114 scopoletin 1.73284 µM -0.166421043579995 0.434595243286386 no 1922 0.433912807243681 2700 5280460 A coumarin with genotoxic properties.
SGTC_563 tetrahydrosecaminediol 614 µM -0.166951492367076 0.434394756930112 no 1923 0.4337041083077 2830 334274 A psychoactive constituent of the cannabis plant.
SGTC_1113 artemisinin 1.17947 µM -0.167554934792276 0.434166702699156 no 1924 0.433466713343936 2740 2240 An anti-malaria and mitochondrial poison.
SGTC_180 1486-1293 102.781 µM -0.167589520989204 0.434153632473962 no 1925 0.43345310781961 2738 4140536
SGTC_2677 mitomycin C 100 µM -0.167706866918588 0.434109287639811 no 1926 0.433406946844726 2714 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_722 3534-0461 190 µM -0.169142680361139 0.433566763404525 no 1927 0.432842207234727 2754 658262
SGTC_1638 st008370 60.6 µM -0.170677840409505 0.432986839362591 no 1928 0.432238543963948 2680 24207134
SGTC_750 4073-0104 132 µM -0.171162964808599 0.432803608086893 no 1929 0.432047813753973 2782 22330957
SGTC_44 0929-0055 61.211 µM -0.172594328306355 0.432263067056833 no 1930 0.431485155174574 2719 1379590
SGTC_2396 5342950 42.78 µM -0.172631880295336 0.432248887601693 no 1931 0.431470395626941 2792 1886677
SGTC_1295 1013-0063 9.78 µM -0.173688891350997 0.431849801043233 no 1932 0.431054984121916 2766 6826038
SGTC_2847 9005661 71.43 µM -0.174581759428322 0.431512742699039 no 1933 0.430704141160837 2694 2991449
SGTC_2848 9016370 25.97 µM -0.174582201882042 0.431512575684781 no 1934 0.430703967316914 2747 7894410
SGTC_745 0469-0705 296 µM -0.176300509235737 0.430864053981343 no 1935 0.430028930993753 2863 3486736
SGTC_1784 st039334 36.3 µM -0.176516854771957 0.430782414257744 no 1936 0.429943954192942 2961 3496984
SGTC_1775 st081588 35.1725 µM -0.176982176894413 0.430606831249186 no 1937 0.429761194677638 2732 1426443 YGL099W LSG1
SGTC_1337 1486-1011 40.3 µM -0.177665879606613 0.430348870173416 no 1938 0.429492691503857 2714 X1337
SGTC_1819 st053448 58.6 µM -0.178481449502844 0.43004119448362 no 1939 0.429172444222054 2743 2857616
SGTC_1659 st012954 42.1 µM -0.180466882653855 0.429292363019017 no 1940 0.42839302566572 2858 24207262
SGTC_2826 7992541 19.48 µM -0.180583626404465 0.429248339515062 no 1941 0.428347204406908 2681 2985066
SGTC_2779 methotrexate 400 µM -0.180624852148336 0.42923279369657 no 1942 0.428331023767431 2746 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2018 5133068 143 µM -0.180704773751221 0.429202656366698 no 1943 0.428299655782974 2718 785362
SGTC_2307 7538926 6.34 µM -0.181298373624795 0.428978830999839 no 1944 0.428066691267789 2791 96582
SGTC_2803 7707263 71.43 µM -0.181718172171741 0.428820553703133 no 1945 0.427901952041126 2752 2199229
SGTC_1469 k284-2957 126 µM -0.184564569757222 0.427747675185266 no 1946 0.426785288844892 2761 23884841
SGTC_2114 5491910 81.25 µM -0.185478843444267 0.427403175470201 no 1947 0.426426736420267 2846 2849228
SGTC_2896 9052656 71.43 µM -0.185812148988298 0.427277599187521 no 1948 0.426296038467601 2777 6469436
SGTC_556 4058-0063 51.5 µM -0.186148421266111 0.42715091262436 no 1949 0.426164185382452 2735 6615692
SGTC_2529 gangaleoidin 93.61 µM -0.186265800346007 0.427106693226583 no 1950 0.426118162734661 2744 4565183
SGTC_821 1114-0266 29.2 µM -0.186562869362846 0.426994784592303 no 1951 0.426001690746065 2816 3123235
SGTC_1497 4476-2978 41.3 µM -0.186715390376835 0.426937330803902 no 1952 0.42594189426784 2814 1528379
SGTC_2915 7971052 15.16 µM -0.187011340090207 0.426825852672361 no 1953 0.425825870849001 2724 5741558
SGTC_1347 1493-0251 600 nM -0.188627593778129 0.426217146703125 no 1954 0.425192352161862 2867 3986378
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.188803604267501 0.426150869033735 no 1955 0.425123373426851 2694 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3232 9132874 49.47 µM -0.189193163475737 0.426004185898152 no 1956 0.424970712830803 2749 3784940
SGTC_2889 9059656 51.95 µM -0.18949708776518 0.425889754515696 no 1957 0.424851618687886 2831 3949838
SGTC_3243 9134147 49.47 µM -0.189835740840263 0.425762254652659 no 1958 0.42471892398881 2769 24282180
SGTC_1287 0971-0001 34.6 µM -0.190078761445293 0.425670764344287 no 1959 0.424623706291569 2738 4665869
SGTC_2552 juarezic acid 87.02 µM -0.190683586835992 0.425443082263223 no 1960 0.424386749274448 2711 1549512
SGTC_391 gliotoxin 8.33 µM -0.191612335519594 0.425093510057561 no 1961 0.42402293960699 2891 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2218 6965428 192.983 µM -0.192143486836278 0.424893616185846 no 1962 0.423814905959119 2735 675684
SGTC_1626 st003712 1.76 µM -0.193086289907595 0.424538848584977 no 1963 0.423445694842486 2895 24207035
SGTC_2682 pyrogallin 40.03 µM -0.193214837675707 0.424490482042261 no 1964 0.423395359449502 2788 822798 An ATP competetive kinase inhibitor.
SGTC_677 0929-0063 136 µM -0.195066763263342 0.423793815160648 no 1965 0.42267034090075 2730 1539583
SGTC_1588 farnesol 29.9 µM -0.195590047656012 0.423597006401854 no 1966 0.422465525323525 2756 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2584 androsterone 48.74 µM -0.196797633243292 0.423142902821001 no 1967 0.421992951649043 2866 2754130 A steroid.
SGTC_1027 k015-0025 8.67 µM -0.20132386665533 0.421441759565331 no 1968 0.420222670857712 2741 3598955
SGTC_2079 5212404 121 µM -0.202022067416796 0.421179476872816 no 1969 0.419949736275799 2850 758462
SGTC_1855 st056195 39.6 µM -0.202474397555208 0.42100957540063 no 1970 0.419772935843949 2950 4028379
SGTC_2147 5545932 89.7195 µM -0.203119786300037 0.420767183913349 no 1971 0.419520703424891 2788 797404
SGTC_1646 st011709 75.6 µM -0.203498019317366 0.420625143230126 no 1972 0.41937289682529 2815 5757843
SGTC_2047 4141938 200 µM -0.206293740022195 0.419575566929678 no 1973 0.41828073405588 2789 3807862
SGTC_1071 trifluoperazine 6.31 µM -0.206969078423507 0.419322115213784 no 1974 0.418017003732294 2923 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1783 st039459 87.517 µM -0.20928785920617 0.418452141736459 no 1975 0.417111764436027 2995 729761
SGTC_2952 9073731 13.78 µM -0.209788093066849 0.418264513271286 no 1976 0.416916533316411 2790 16457353
SGTC_2985 9022375 71.43 µM -0.212515999389367 0.417241654408828 no 1977 0.415852248566317 2984 4939335
SGTC_895 0964-0006 13.7 µM -0.212805784353872 0.41713302908211 no 1978 0.415739225911671 2839 6738897
SGTC_1519 esterone 74 µM -0.213349188307327 0.416929352231102 no 1979 0.415527304942163 2780 698 A steroid.
SGTC_645 0845-0943 5.41 µM -0.215443311802054 0.416144648848491 no 1980 0.414710852404542 2830 1885106
SGTC_2412 st077135 33.4 µM -0.216182270348773 0.415867828219985 no 1981 0.414422836503567 3061 13258915
SGTC_2754 granisetron 64.02 µM -0.216320738400726 0.415815961460866 no 1982 0.414368872418353 2921 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_99 0109-0120 622.8 µM -0.218202215694138 0.415111351596904 no 1983 0.413635779401139 2828 759414
SGTC_184 1494-0393 24.714 µM -0.218665245927273 0.414937989372176 no 1984 0.413455411770368 2756 3090647
SGTC_2356 9061756 188.97 µM -0.221164039511639 0.414002707761466 no 1985 0.412482354128029 2881 20104043
SGTC_728 3030-5151 22.5 µM -0.221747494946775 0.413784394336839 no 1986 0.412255227385544 2783 3125388
SGTC_2341 7987486 176.74 µM -0.22208911074431 0.413656583201708 no 1987 0.412122257284049 2937 1258686
SGTC_472 calcifediol 10 µM -0.222776443294232 0.413399454342027 no 1988 0.411854751412967 2866 5283731 A vitamin D metabolite.
SGTC_2317 5986382 200 µM -0.222995619635868 0.413317468993072 no 1989 0.411769457849664 2859 877883
SGTC_2477 5967686 25.23 µM -0.224355994267952 0.412808690392845 no 1990 0.411240154680769 2789 776118
SGTC_2268 7933382 153.85 µM -0.224680496069595 0.412687348679308 no 1991 0.411113919291915 2756 935025 YOR257W CDC31
SGTC_2567 aureobasidin a 60 nM -0.225727745643652 0.412295805177196 no 1992 0.410706588533967 3064 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2945 9067681 61.76 µM -0.226753368338706 0.411912432072579 no 1993 0.410307762927476 2748 16456930
SGTC_2273 7815444 169.05 µM -0.228141698078658 0.411393614693533 no 1994 0.409768042176426 3006 2824616
SGTC_3177 9107506 49.47 µM -0.228198742900717 0.411372300410016 no 1995 0.409745869340058 2935 8897194
SGTC_1402 3909-7673 35.9 µM -0.228556892563622 0.411238486996184 no 1996 0.409606666214724 2781 5328014
SGTC_290 2043-6722 48.1 µM -0.228872329865916 0.411120640509544 no 1997 0.409484073669803 2886 773758 YLR208W SEC13
SGTC_226 1,3-diallylurea 8.28947 mM -0.229837105344515 0.410760252933101 no 1998 0.40910917527337 2900 74537 YKL182W FAS1
SGTC_2775 cyproheptadine 69.59 µM -0.23094933052506 0.410344879663254 no 1999 0.408677083132154 2889 2913 A selective serotonin reuptake inhibitor.
SGTC_2971 9092186 9.93 µM -0.23167112498949 0.410075371002119 no 2000 0.408396730094263 2777 25236400
SGTC_1901 st060216 58.6 µM -0.233481869242185 0.409399449846001 no 2001 0.407693623397951 2818 688792
SGTC_643 k048-0106 28.4 µM -0.233595124477631 0.409357182448502 no 2002 0.407649656574196 2929 6763920
SGTC_1234 0326-0494 15.5 µM -0.23422687723096 0.409121428633536 no 2003 0.407404425144072 2966 1547813
SGTC_2606 farnesol 9.78 µM -0.235901065037018 0.408496824157909 no 2004 0.406754720896276 3000 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_967 1306-0166 352 µM -0.235933023268205 0.408484903465044 no 2005 0.406742321313615 2966 4437607
SGTC_3306 9127676 59.7925 µM -0.237673550781555 0.407835800030093 no 2006 0.406067149657345 2908 41905287
SGTC_1092 toremifene 6.32 µM -0.237789982368172 0.407792387634289 no 2007 0.406021994381207 2813 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1893 st059353 36.1 µM -0.237877270442603 0.407759842359459 no 2008 0.405988142556667 2877 3112488
SGTC_42 0133-0086 60.653 µM -0.238978231179928 0.407349404921653 no 2009 0.405561231369869 2774 162923 Model of phenazepam hydroxylation.
SGTC_265 mycophenolic acid 32.932 µM -0.239158725272626 0.407282126534012 no 2010 0.405491253248125 3063 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1737 st035557 69.7 µM -0.240550547220684 0.406763422969246 no 2011 0.40495174116071 2757 5716916
SGTC_633 0437-0093 97.7 µM -0.240810823504958 0.406666441445032 no 2012 0.404850870252114 2826 2831118
SGTC_2031 5180455 200 µM -0.241009314425824 0.406592485606623 no 2013 0.404773948707988 2829 29949
SGTC_522 1273-0010 11.6 µM -0.242936056732205 0.405874773167504 no 2014 0.404027466440509 3066 5705015
SGTC_3152 9099253 49.47 µM -0.244028543890178 0.405467961513129 no 2015 0.403604356616356 2933 25236131
SGTC_952 1185-0122 232 µM -0.245505334256155 0.404918208450836 no 2016 0.403032589199796 2791 678600
SGTC_49 0717-0965 32.132 µM -0.245751577815533 0.404826559529166 no 2017 0.402937271461914 3128 5889349 YGL099W LSG1
SGTC_936 3005-4620 401 µM -0.247319112024979 0.404243264548703 no 2018 0.402330634437735 3055 777207
SGTC_3315 9136395 68.55 µM -0.247345879184548 0.404233306068249 no 2019 0.402320277562926 2932 16876844
SGTC_796 1234-0020 70.7 µM -0.248262681168387 0.403892255656914 no 2020 0.401965585684988 2828 46495034
SGTC_100 0086-0128 49.5915 µM -0.249010047597183 0.403614289318824 no 2021 0.401676504656895 2872 93297
SGTC_535 2293-4129 48.2 µM -0.249519140515883 0.403424971382744 no 2022 0.401479618517486 2990 396118 YIL048W NEO1
SGTC_192 3455-0609 60.9 µM -0.252184137232116 0.402434301188765 no 2023 0.400449369288807 2986 3769639
SGTC_2222 6885208 172.143 µM -0.252804454832996 0.402203797593824 no 2024 0.400209662521515 2883 609514
SGTC_3014 9081533 49.47 µM -0.254230996132361 0.401673838766589 no 2025 0.399658552816687 3007 21367265
SGTC_2174 5790901 200 µM -0.254285143543442 0.40165372660644 no 2026 0.399637638204847 2938 786020
SGTC_262 fenpropimorph 62.5 µM -0.254862398021106 0.401439331180991 no 2027 0.399414689715229 2839 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_546 peri-Naphthalide 147 µM -0.254967464450188 0.4014003121322 no 2028 0.399374114254703 2928 223824 A penicillin ester.
SGTC_1841 st054148 70 µM -0.255706248672536 0.401125973899414 no 2029 0.399088834902694 2945 675442
SGTC_3239 9133757 49.47 µM -0.256001780757648 0.40101624541652 no 2030 0.398974731139829 2835 17036923
SGTC_2555 cholic acid 100 µM -0.256448090775822 0.400850549205499 no 2031 0.398802428981722 3022 6708657 Influences liver metabolism.
SGTC_1005 4092-0690 4.4 µM -0.257443110009197 0.400481204500867 no 2032 0.398418363534138 2922 1529343
SGTC_663 1486-0733 13.9 µM -0.257614104396114 0.400417741439639 no 2033 0.398352371654094 2860 722445 YPR165W RHO1
SGTC_261 5-fluorouridine 15.376 µM -0.257988243792723 0.400278892068075 no 2034 0.39820799014212 3071 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2173 5763948 167 µM -0.258183341618462 0.400206493008664 no 2035 0.398132706834615 2831 2867177
SGTC_3278 9139605 49.47 µM -0.258689809261076 0.400018563405594 no 2036 0.397937291510195 3062 7958859
SGTC_1338 1486-1223 76 µM -0.259017798454045 0.399896872266215 no 2037 0.39781075391284 2934 3444526
SGTC_2223 6903751 107.57 µM -0.2594858990001 0.399723213600817 no 2038 0.397630180247528 2955 5598863
SGTC_2867 9039098 71.43 µM -0.259873922035007 0.399579277589333 no 2039 0.397480513769428 2847 6463460
SGTC_259 usnic acid 108.925 µM -0.262610012556128 0.398564721251142 no 2040 0.396425590981092 3068 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2017 5132927 60.65 µM -0.262907019129693 0.398454630799316 no 2041 0.396311123048814 2891 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1096 rimcazole 32.2 µM -0.263999141309836 0.398049887007908 no 2042 0.395890290211243 2848 18528119 A dopamine reuptake inhibitor.
SGTC_1350 1495-0454 146 µM -0.266385749589914 0.397165785038391 no 2043 0.394971069519457 3036 1069057
SGTC_3129 9127257 49.47 µM -0.266979777762817 0.39694581346218 no 2044 0.394742365574061 2899 837894
SGTC_766 1391-0721 126 µM -0.2685575359293 0.396361721145313 no 2045 0.39413509674154 3045 1020919 YIL115C NUP159
SGTC_949 1165-0505 146 µM -0.269398212782096 0.396050594122024 no 2046 0.393811630667922 2899 6244267
SGTC_1736 st036774 51 µM -0.269886714106752 0.395869834527612 no 2047 0.393623704321505 3127 1272247
SGTC_744 1594-0068 283 µM -0.270416811459438 0.395673708534845 no 2048 0.393419804022815 2920 668392
SGTC_89 0302-0250 142.109 µM -0.271015881115055 0.39545209588943 no 2049 0.393189408922932 2861 4203518 YLR208W SEC13
SGTC_739 1486-1183 203 µM -0.27194615777871 0.395108027520536 no 2050 0.392831709693819 3010 4346692
SGTC_775 4577-0580 57.3 µM -0.272369354119795 0.394951532875041 no 2051 0.392669017054481 3072 2006902
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.273996374468006 0.394350031693799 no 2052 0.392043703919788 2974 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_783 0848-0141 92.7 µM -0.275077128813334 0.393950621400865 no 2053 0.391628491289152 2864 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_264 promethazine 12.5 mM -0.276299174901107 0.393499128811608 no 2054 0.391159144797045 2933 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1864 st057645 30.4 µM -0.276402383053636 0.393461004460188 no 2055 0.391119513289889 2941 688666
SGTC_2110 5483698 200 µM -0.278662213622816 0.392626495894796 no 2056 0.390252031689078 2955 2848765 YHR062C RPP1
SGTC_1097 itavastatin 7.23 µM -0.278762521225271 0.392589465785637 no 2057 0.390213539218076 2930 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_473 2-arachidonoylglycerol 10 µM -0.27993280407732 0.392157509627663 no 2058 0.389764529465425 2846 5282280 An endocannabinoid.
SGTC_357 1325-0123 420 µM -0.279981888885701 0.39213939512484 no 2059 0.389745699999221 3029 1098503
SGTC_188 3229-0966 278.469 µM -0.280865783237157 0.39181323837957 no 2060 0.389406672841157 2989 5722370
SGTC_367 0335-0881 7.1 µM -0.281251749747485 0.391670840686847 no 2061 0.389258657629366 3066 23828853
SGTC_786 4544-0069 423 µM -0.282102713916223 0.391356939009005 no 2062 0.388932376153952 3017 748821 YLR208W SEC13
SGTC_1020 4335-0961 93.3 µM -0.285766342310569 0.39000631861697 no 2063 0.387528544259121 2870 669075
SGTC_2522 biochanin a 4.94 µM -0.286563115404313 0.38971275814203 no 2064 0.387223430022037 3037 5280373 A possible chelator.
SGTC_2653 dihydrofissinolide 100 µM -0.290742272784299 0.38817403699217 no 2065 0.385624219228874 2986 6857746
SGTC_672 1441-0018 53.7 µM -0.291218620511847 0.387998761733268 no 2066 0.385442061171816 2908 251141
SGTC_2674 ligustilide 100 µM -0.291512761994051 0.387890541843856 no 2067 0.385329592426454 3012 5319022 A signalling regulator.
SGTC_481 bay k-8644 50 µM -0.29353553371721 0.387146564340878 no 2068 0.38455642152523 2925 2303 A calcium channel antagonist.
SGTC_1422 4031-0024 15.5 µM -0.294361806585345 0.386842779383338 no 2069 0.384240724302525 2984 782427
SGTC_326 k292-0812 17.5 µM -0.294974833383354 0.386617440602048 no 2070 0.384006552418169 3004 3579357
SGTC_1694 st024011 44.9 µM -0.295886352231834 0.386282451642192 no 2071 0.383658436998657 2996 2787533
SGTC_2800 7887935 81.82 µM -0.29616574313392 0.38617979067059 no 2072 0.383551754444918 3107 2961002
SGTC_1155 4088-0394 48.2 µM -0.296700875149049 0.385983180992834 no 2073 0.38334744441877 2902 2326248
SGTC_3032 9089427 49.47 µM -0.296793809289667 0.385949039594488 no 2074 0.383311966054596 3032 17173707
SGTC_425 3825-7017 13.1 µM -0.296869990593458 0.385921053377642 no 2075 0.383282883952006 3168 3397440
SGTC_3118 9124250 49.47 µM -0.297768714368565 0.385590940079502 no 2076 0.382939847139414 2976 1504786
SGTC_84 0443-0269 128.823 µM -0.299573707111771 0.384928192564055 no 2077 0.382251171116145 2972 6150058
SGTC_1859 st055998 20 µM -0.300156681843416 0.384714210744439 no 2078 0.382028822669702 3123 676301
SGTC_382 3229-0966 23.2 µM -0.305420786382249 0.382783610126913 no 2079 0.380022846194388 3111 5722370
SGTC_1387 3342-1166 1.8 µM -0.305481310386624 0.382761429883935 no 2080 0.379999801136271 2995 3418228
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.306395351414676 0.382426507889745 no 2081 0.379651823656983 3125 94937 An inhibitor of serotonin biosynthesis.
SGTC_2019 4016004 108 µM -0.306396880440929 0.382425947699085 no 2082 0.379651241634805 3023 45595336
SGTC_979 1426-2828 121 µM -0.306640419516017 0.382336725220607 no 2083 0.379558542232452 3077 747872
SGTC_2160 5660466 132.927 µM -0.307540300527125 0.382007100868387 no 2084 0.379216076453811 3007 2859134
SGTC_1390 3413-2614 145 µM -0.307899171590031 0.381875671058319 no 2085 0.379079528083695 3010 3421432
SGTC_1380 2291-0730 164 µM -0.309459666984775 0.381304327314525 no 2086 0.378485944228348 3050 2999191
SGTC_3115 9123671 49.47 µM -0.310440028868524 0.380945519869128 no 2087 0.378113179021526 3014 3286988
SGTC_863 0466-0191 129 µM -0.31154620646669 0.380540787418534 no 2088 0.377692710840438 3080 765160 YPR165W RHO1
SGTC_1548 st061468 90.8 µM -0.313351991246936 0.379880361091954 no 2089 0.377006627106042 3077 390799
SGTC_229 benomyl 22.8748 µM -0.313747923590345 0.379735604228012 no 2090 0.376856249723272 3029 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3108 9121785 49.47 µM -0.314925377348107 0.379305214889974 no 2091 0.376409156465417 2881 17140271
SGTC_2416 tofa 880 nM -0.317435490482749 0.378388204412178 no 2092 0.3754565905551 2968 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_456 gingerol 170 µM -0.318846048129483 0.377873190583434 no 2093 0.374921628929187 3158 442793 A herb.
SGTC_2049 5262831 67.185 µM -0.320011132064561 0.377447966140754 no 2094 0.374479945891908 3046 763417
SGTC_1031 k035-0009 16 µM -0.320016437071039 0.377446030294708 no 2095 0.374477935141381 3147 5180959
SGTC_830 4076-0286 57.8 µM -0.322383455532443 0.376582591166603 no 2096 0.37358110815456 2967 6866659
SGTC_1607 st000305 50.6 µM -0.322481027517184 0.376547012148678 no 2097 0.373544154276288 3119 5457690
SGTC_1518 st038567 90.8 µM -0.322604925848241 0.376501834903526 no 2098 0.373497231377715 3009 77966
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.322645859613359 0.376486909531485 no 2099 0.373481729313811 3024 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1229 0139-0193 12.2 µM -0.323367035289223 0.376223982953156 no 2100 0.373208645808605 3141 3090752
SGTC_3099 9120367 49.47 µM -0.324144649670996 0.375940544276029 no 2101 0.372914262329083 2961 24824940
SGTC_1062 mesoridazine 14.2 µM -0.325123063315468 0.375584009804208 no 2102 0.372543967178953 2963 4078 A neuroleptic.
SGTC_1260 0700-1617 7.75 µM -0.325196140525751 0.375557384687874 no 2103 0.372516314748064 3091 2853078
SGTC_2282 7944268 200 µM -0.325844665850373 0.375321125483096 no 2104 0.372270941444543 3180 2970414
SGTC_1427 4048-4900 550 nM -0.326505118192019 0.375080569295995 no 2105 0.372021108771273 3098 24132586
SGTC_634 1611-4317 11.2 µM -0.327485908146996 0.37472342638437 no 2106 0.371650199781603 3045 2843522
SGTC_177 1327-0068 8.361 µM -0.327665296116017 0.374658116016622 no 2107 0.371582372841471 3072 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_832 4083-0019 164 µM -0.329618278552016 0.373947320284459 no 2108 0.370844204760739 3118 1990758
SGTC_3174 9107204 49.47 µM -0.33071612396512 0.373547943016308 no 2109 0.370429460930008 3113 3938802
SGTC_480 am 92016 50 µM -0.331601768195127 0.373225859804709 no 2110 0.370094992117989 3057 2129 K+ channel blocker.
SGTC_841 0251-0215 91.2 µM -0.333231143724278 0.372633534508127 no 2111 0.369479905483024 3046 3888614
SGTC_2016 5121758 140 µM -0.333261118284307 0.372622640701656 no 2112 0.369468593258042 2940 2795203
SGTC_564 3555-0129 330 µM -0.333633617951652 0.372487269760654 no 2113 0.369328023476284 3005 563260
SGTC_2235 salicylic acid 500 µM -0.335452133081541 0.371826625527622 no 2114 0.368642023590644 3038 338 A COX inhibitor and kinase inhibitor.
SGTC_2797 7859098 81.82 µM -0.336186380009237 0.371559989422891 no 2115 0.368365161491243 3003 972681
SGTC_1889 st059080 5.18 µM -0.33693270888629 0.371289028992283 no 2116 0.368083813687489 3171 176925 Isolated from Daphnopsis sellowiana.
SGTC_2563 tomatine 8.54 µM -0.337128996872682 0.371217775719295 no 2117 0.368009829642134 3204 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1104 tacrolimus 29.8 µM -0.337363254509826 0.371132745098625 no 2118 0.367921540643131 3037 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3056 9094900 49.47 µM -0.337674327387853 0.371019841876452 no 2119 0.367804311651512 3032 25236784
SGTC_642 0335-0876 158 µM -0.337678380210381 0.371018370986602 no 2120 0.367802784411235 3004 6812350
SGTC_698 k064-0052 127 µM -0.33794239265676 0.370922557077204 no 2121 0.367703300117178 3061 5088751
SGTC_86 0417-1630 471.922 µM -0.338657241967586 0.370663168175945 no 2122 0.367433977540457 3091 3634867
SGTC_1813 st051246 8.6015 µM -0.338734424510666 0.370635165374519 no 2123 0.367404902579999 3104 5291959
SGTC_2851 9015922 71.43 µM -0.339088318271554 0.37050677702569 no 2124 0.367271599176304 3176 2996893
SGTC_1485 3909-9022 254 µM -0.34199615161867 0.369452397744694 no 2125 0.366176894200957 3065 714516
SGTC_755 1995-0008 37.3 µM -0.342290975085995 0.369345549514376 no 2126 0.366065963341885 3129 689533
SGTC_1821 st053465 65.6 µM -0.342524413918745 0.369260955109489 no 2127 0.365978137126681 3078 675086
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.343178310044039 0.369024027591059 no 2128 0.365732160521164 3068 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_109 0132-0036 33.701 µM -0.343624662751227 0.36886232827115 no 2129 0.365564287371644 2949 67274 A color developer.
SGTC_432 NS 1619 61.3 µM -0.343642113262585 0.368856006979887 no 2130 0.36555772476114 3176 4552 A K+/calcium channel activator.
SGTC_2561 acetosyringone 100 µM -0.344854625155354 0.368416872378999 no 2131 0.365101832107016 2974 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_690 glyoxal 20.3 µM -0.344930883076317 0.368389259837004 no 2132 0.365073166235992 3057 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2994 9053520 71.4286 µM -0.345429368624787 0.368208777918819 no 2133 0.364885800709327 3131 4647384
SGTC_1493 4348-0038 111 µM -0.346504985924576 0.367819438522943 no 2134 0.364481618904535 3088 800424
SGTC_3076 9116187 49.47 µM -0.346514191547843 0.367816106964305 no 2135 0.364478160381804 3109 27241210
SGTC_2100 5377183 190 µM -0.346644400694894 0.367768984722868 no 2136 0.364429242410364 3086 2844202
SGTC_2361 9034121 116 µM -0.347054148771502 0.367620711295659 no 2137 0.364275319518552 3034 6496917
SGTC_1282 0886-0010 32.4 µM -0.347484330337285 0.367465064937049 no 2138 0.364113744287165 3200 2836211 YNL267W PIK1
SGTC_2466 5983409 37.09 µM -0.347938645223244 0.367300710405559 no 2139 0.363943130856349 3047 2879657
SGTC_892 0929-0076 29 µM -0.34852299624561 0.367089349294349 no 2140 0.363723723303999 3029 5751038
SGTC_112 phenothiazine 287.218 µM -0.348883690103072 0.366958905593404 no 2141 0.363588315091868 3173 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_612 0302-0167 22.4 µM -0.351477753681117 0.366021224629705 no 2142 0.362614979598277 3090 235821
SGTC_474 dl-dihydrosphingosine 5 µM -0.352036467277804 0.365819369862865 no 2143 0.362405456934156 3168 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_580 1123-0028 41 µM -0.353258273909934 0.365378079106249 no 2144 0.36194741203303 3030 1677248 YPR107C YTH1
SGTC_1150 3909-7983 10.9 µM -0.353740492052023 0.365203961097035 no 2145 0.361766686924385 3050 23965914
SGTC_609 0986-0026 86.3 µM -0.354939010288139 0.3647713238182 no 2146 0.361317641363557 3031 2848610
SGTC_2464 5717415 7.67 µM -0.356072497262034 0.364362319684165 no 2147 0.360893136599901 3040 5285744
SGTC_1651 st011928 86.1 µM -0.356906886492967 0.364061339736837 no 2148 0.360580757039395 3132 720198
SGTC_2201 6605497 169.863 µM -0.356983949441307 0.364033545902667 no 2149 0.360551910816861 3061 670741
SGTC_1935 st074532 41.6 µM -0.359819500621067 0.363011362983883 no 2150 0.359491059606499 3135 2829742
SGTC_172 1112-0046 2.638 µM -0.360634842646377 0.362717621938464 no 2151 0.359186219522831 3038 2802135 YIL048W NEO1
SGTC_816 0325-0417 81.3 µM -0.360761085441495 0.362672148008396 no 2152 0.359139027873606 3088 68101
SGTC_705 1124-0212 310 µM -0.361459178822224 0.362420722705674 no 2153 0.358878107817368 3197 9554485
SGTC_2883 9059145 45.46 µM -0.363688128485937 0.361618341826852 no 2154 0.358045454632716 2982 16476510
SGTC_1047 2043-3044 82 µM -0.365513270527608 0.360961776897653 no 2155 0.357364151316364 3064 669592
SGTC_165 k038-0023 64.381 µM -0.366843614074851 0.36048346550297 no 2156 0.356867836432798 3056 46368543
SGTC_3016 9080866 49.47 µM -0.367157730500069 0.360370559979753 no 2157 0.356750683474759 3051 17066299
SGTC_2790 5423970 71.43 µM -0.367511798341017 0.360243308977653 no 2158 0.35661864642231 3224 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_689 0833-0039 98 µM -0.370634582888803 0.359121660704125 no 2159 0.355454860178784 3100 5374726
SGTC_1137 ixabepilone 100 µM -0.371371356687528 0.358857201289776 no 2160 0.355180478323421 3018 154225 A novel microtubule stabilizer.
SGTC_1950 st077106 7.18 µM -0.371809550318708 0.358699947051018 no 2161 0.355017326268158 3136 13831864
SGTC_3130 9127414 49.47 µM -0.371963904442919 0.358644559798375 no 2162 0.354959862130094 3125 1494646
SGTC_2987 9018338 71.43 µM -0.372242685450615 0.358544531689132 no 2163 0.354856083757977 3195 5055682
SGTC_862 0452-0056 10.2 µM -0.372751039599694 0.358362156499398 no 2164 0.354666872747513 3137 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.373310747449 0.358161395217213 no 2165 0.354458589195593 3180 1377
SGTC_2115 tiliquinol 12.7705 µM -0.373529136213322 0.35808307211013 no 2166 0.354377332190361 3119 71208 A bioactive hydroxyquinoline.
SGTC_808 0711-0032 135 µM -0.374252599536385 0.357823651372078 no 2167 0.354108196922283 3168 4252555
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.37698430745556 0.356844703643882 no 2168 0.353092633439973 3107 97141
SGTC_1309 pyrazolanthrone 13.4 µM -0.377450919234957 0.356677580465401 no 2169 0.352919266134027 3180 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1489 4065-0444 182 µM -0.377869551188633 0.356527665306812 no 2170 0.352763751478393 3185 2877968
SGTC_3038 9091290 49.47 µM -0.380268260635783 0.355669097913134 no 2171 0.351873146676039 3234 25236843
SGTC_2137 5261020 140 µM -0.382826459750257 0.35475425084639 no 2172 0.350924220638048 3061 763655
SGTC_1974 st069448 26.9 µM -0.38292458045876 0.354719178171014 no 2173 0.350887842678852 3215 6323587 YNR016C ACC1
SGTC_3102 9121669 49.47 µM -0.383237772043232 0.354607237904302 no 2174 0.350771736981098 3098 41905072
SGTC_1400 3771-8998 51.5 µM -0.38327447516804 0.35459412037359 no 2175 0.350758131391139 3067 670767
SGTC_223 busulfan 5 mM -0.383527793786377 0.35450359014869 no 2176 0.350664233182663 3162 2478 A DNA alkylator.
SGTC_3220 9131269 49.47 µM -0.383549738386716 0.354495748042009 no 2177 0.350656099355283 3146 17722206
SGTC_1088 bifonazole 369 nM -0.383641406311381 0.354462990325028 no 2178 0.350622123123414 3154 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_726 3448-4391 34.2 µM -0.384620730027143 0.354113094256568 no 2179 0.350259216581272 3261 1356692
SGTC_1505 k297-0037 20.6 µM -0.385470068801548 0.35380973933853 no 2180 0.349944589019515 3099 4089396
SGTC_3168 9103419 49.47 µM -0.385597942707588 0.353764075161677 no 2181 0.349897228550168 3155 16649256
SGTC_1465 k213-0056 144 µM -0.385871289229537 0.35366646930917 no 2182 0.349795997435314 3065 24048857 YMR208W ERG12
SGTC_12 0849-0099 9.267 µM -0.387127312287394 0.353218095661291 no 2183 0.34933097936712 3149 6071388
SGTC_3266 9136860 49.47 µM -0.388425997475921 0.35275470669926 no 2184 0.348850404187087 3171 4871271 YPR165W RHO1
SGTC_2894 9048625 32.47 µM -0.388548399356142 0.352711043253797 no 2185 0.348805122167013 3265 4092861
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.388629409295281 0.352682146291928 no 2186 0.348775154091939 3377 5282309
SGTC_2703 st077852 53.4 µM -0.389171207442621 0.352488903960139 no 2187 0.348574750510264 3192 6281836
SGTC_3325 9138760 55.175 µM -0.389842047301883 0.35224968926356 no 2188 0.348326674747835 3096 43844959
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.391256426448903 0.351745527595268 no 2189 0.347803851739095 3272 688751
SGTC_2202 7226349 200 µM -0.39256723824815 0.351278515605689 no 2190 0.347319570465176 3078 844334
SGTC_1484 3473-2379 286 µM -0.39286764330452 0.351171519808124 no 2191 0.347208620457192 3195 671917
SGTC_2511 berberine 10.47 µM -0.39301019090974 0.351120752502992 no 2192 0.347155977261931 3090 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_906 1165-0455 526 µM -0.394552727261404 0.350571559370818 no 2193 0.346586503456278 3101 3252859
SGTC_2255 7941087 197.44 µM -0.396574935887469 0.349852060297413 no 2194 0.345840469197105 3249 935561
SGTC_1210 3013-0140 750 nM -0.397526905120574 0.349513537314972 no 2195 0.345489475090033 3216 905973
SGTC_3035 9091303 49.47 µM -0.397561056192101 0.34950139531777 no 2196 0.345476885946464 3158 25237002
SGTC_2665 lovastatin 100 µM -0.397588200608164 0.349491744561346 no 2197 0.345466879795207 3145 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2291 7917025 104.35 µM -0.39824743121976 0.349257395704927 no 2198 0.345223903090716 3042 2964612
SGTC_1722 st034304 3.6505 µM -0.398754837872853 0.349077057638891 no 2199 0.345036928516685 3106 4036148 YLR033W RSC58
SGTC_2832 7992762 51.95 µM -0.401311961007635 0.348168746492648 no 2200 0.344095229218081 3020 2985177
SGTC_1643 st009866 20.2 µM -0.401870206981582 0.347970568488708 no 2201 0.343889774957008 3198 3156273 YOR207C RET1
SGTC_2326 6164455 177.58 µM -0.403173636919551 0.347508010987906 no 2202 0.343410246163562 3160 2888790
SGTC_79 0052-0007 94.094 µM -0.403186596344637 0.34750341312252 no 2203 0.34340547968544 3262 2801472
SGTC_2710 st078562 53.7235 µM -0.403621415904182 0.347349156803208 no 2204 0.343245567439243 3066 17250908
SGTC_1951 sophoraflavanone G 9.2 µM -0.403702620740284 0.347320351426313 no 2205 0.34321570609655 3109 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1765 st044815 90.4 µM -0.403975432888533 0.347223584624675 no 2206 0.343115392430133 3198 645695
SGTC_3044 9093193 49.47 µM -0.404541993931422 0.347022656554875 no 2207 0.342907101931988 3198 25236277
SGTC_407 eburnamonine 100 µM -0.405313233574912 0.346749209351921 no 2208 0.342623640121505 3070 3195
SGTC_160 3453-0671 289.699 µM -0.406061184163188 0.346484095640194 no 2209 0.342348822602834 3109 5322268
SGTC_289 k017-0060 526 µM -0.40617134365219 0.346445055571408 no 2210 0.342308354038955 3126 5512909
SGTC_3196 9111891 49.47 µM -0.407651975525085 0.345920484185746 no 2211 0.341764599974078 3151 18891510
SGTC_2698 st077697 67.5 µM -0.407707425703858 0.345900844541088 no 2212 0.341744242562816 3142 3154499
SGTC_927 2425-1185 123 µM -0.410094889513538 0.345055633512461 no 2213 0.340868170715857 3086 730375
SGTC_1942 st076330 65.2 µM -0.411466509273498 0.344570401124068 no 2214 0.340365246931169 3264 24208414
SGTC_1836 st055642 81 µM -0.413155599645 0.343973209724769 no 2215 0.339746308014834 3141 8571
SGTC_1468 k284-1086 134 µM -0.413437090989954 0.343873723986512 no 2216 0.33964320215452 3170 15996457
SGTC_2880 9042983 58.44 µM -0.414651706614655 0.343444573946246 no 2217 0.339198445192047 3244 6464714
SGTC_1463 k081-0032 34.1 µM -0.415928190691228 0.342993781857037 no 2218 0.3387312751523 3198 977755
SGTC_2071 5230951 39.92 µM -0.417323920760127 0.342501133553184 no 2219 0.338220747058103 3239 1799272
SGTC_3300 9124615 50.48 µM -0.418451954046782 0.342103169340402 no 2220 0.337808353884154 3310 24824903
SGTC_1436 4092-1007 8.32 µM -0.419201866120436 0.341838701293551 no 2221 0.337534304199255 3144 2881121
SGTC_2400 5203494 178.7 µM -0.419627518272143 0.341688623017823 no 2222 0.337378791159355 3180 6777674
SGTC_2715 st079500 56.4 µM -0.419874333895063 0.341601611157315 no 2223 0.337288629196823 3105 28246688
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.420265303241472 0.341463796873538 no 2224 0.337145826877105 3108 15053
SGTC_814 3342-0569 96 µM -0.420544535651977 0.341365382107515 no 2225 0.337043851053308 3232 4346283
SGTC_3347 9188721 44.724 µM -0.420641864762796 0.341331081240231 no 2226 0.337008309224572 3206 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_148 3253-0744 288.01 µM -0.422108239492868 0.340814458097748 no 2227 0.336473007055436 3217 6893655
SGTC_1243 0416-0003 5.65 µM -0.422592003185001 0.340644087187992 no 2228 0.336296481051892 3148 2141977
SGTC_3280 9140961 49.47 µM -0.424061368532541 0.340126808532493 no 2229 0.335760529107184 3120 4901226
SGTC_1411 3909-8223 150 µM -0.424616749729782 0.339931369168139 no 2230 0.335558040351492 3247 X1411
SGTC_3077 9117319 49.47 µM -0.427049744141371 0.339075702809524 no 2231 0.334671548145456 3204 17154678
SGTC_2502 avocadyne acetate 18.59 µM -0.427267035404797 0.338999323342228 no 2232 0.334592420049941 3078 3952079
SGTC_210 3551-0445 56.827 µM -0.428039213903101 0.33872795051747 no 2233 0.334311285441649 3279 2865180 YOR207C RET1
SGTC_16 erodoxin 22.806 µM -0.428171010108322 0.33868164068789 no 2234 0.334263310381174 3283 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_864 0469-0573 172 µM -0.428583757971935 0.338536627382163 no 2235 0.334113083787879 3173 689425
SGTC_1025 k007-0731 70 µM -0.429171454716747 0.338330189495326 no 2236 0.333899227437614 3122 6256118
SGTC_458 nppb 133 µM -0.429261870748327 0.33829843372814 no 2237 0.333866330828471 3336 4549 A chloride channel blocker.
SGTC_1915 st067105 30.6 µM -0.429323767775875 0.338276695020964 no 2238 0.333843811196459 3227 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1747 st037496 66.6 µM -0.42981632917377 0.338103722928055 no 2239 0.333664626810665 3146 723305
SGTC_2684 capsaicin 100 µM -0.430548204056262 0.337846774569695 no 2240 0.333398454833345 3263 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_247 mechlorethamine 29.705 µM -0.432257021843965 0.337247133078333 no 2241 0.332777309976408 3151 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1803 st050068 52.4 µM -0.433042994991316 0.336971465768096 no 2242 0.332491767425156 3281 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2610 ononetin 44.17 µM -0.433138678926042 0.336937912157024 no 2243 0.332457012265402 3231 259632
SGTC_1169 aniline yellow 25.8 µM -0.436150121120772 0.335882550025066 no 2244 0.33136390714396 3179 6051 A DNA damaging agent.
SGTC_1211 1056-0033 32.3 µM -0.43654183648782 0.33574536792896 no 2245 0.331221826043212 3293 6741922
SGTC_2469 5655019 90.81 µM -0.440349639780405 0.334412985192394 no 2246 0.329841946641366 3297 2788239
SGTC_3087 9117406 49.47 µM -0.440486228129922 0.334365230372746 no 2247 0.329792492334861 3267 42546093
SGTC_3009 9080819 71.4286 µM -0.441172527073894 0.33412532309378 no 2248 0.329544050316426 3231 17027216
SGTC_795 0685-0265 78 µM -0.441477784090978 0.334018637161054 no 2249 0.329433570635845 3271 302754
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.442727816712841 0.33358189646352 no 2250 0.328981309883689 3175 2333 A French combination drug.
SGTC_1981 st071826 47 µM -0.443470903691183 0.333322380973888 no 2251 0.328712580187269 3241 11838600
SGTC_3304 9125678 46.087 µM -0.444160900777613 0.333081478000661 no 2252 0.328463129175987 3168 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2504 purpurogallin 52.29 µM -0.44456938940756 0.332938892269901 no 2253 0.328315486448725 3157 5281571 An antioxidant.
SGTC_2246 7293507 91.5585 µM -0.445237890741809 0.332705599451596 no 2254 0.328073923470182 3280 887656
SGTC_2358 9037157 4 µM -0.445455688883587 0.332629606492477 no 2255 0.327995237626498 3263 2388925
SGTC_40 0327-0103 19.753 µM -0.445930969328526 0.332463798070885 no 2256 0.327823555403438 3169 409036
SGTC_3109 9122853 49.47 µM -0.448648070633454 0.331516528324078 no 2257 0.326842775418893 3236 1234709
SGTC_2236 dapsone 200 µM -0.449297313240781 0.331290340407688 no 2258 0.32660859784796 3266 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2716 st080858 38.6235 µM -0.449581058025238 0.33119150662989 no 2259 0.326506274399317 3307 5296050
SGTC_3335 9143315 29.6265 µM -0.453068923398949 0.32997757834346 no 2260 0.325249556038523 3203 4899691
SGTC_911 3456-4043 236 µM -0.453772620696094 0.329732877563842 no 2261 0.324996245910581 3253 914281
SGTC_759 3486-0358 89.3 µM -0.454083152668373 0.329624917628616 no 2262 0.324884489335763 3359 875103
SGTC_3079 9117512 49.47 µM -0.454570297712077 0.3294555847772 no 2263 0.324709203676441 3270 7185044
SGTC_2381 9035592 200 µM -0.455226577425138 0.329227515574784 no 2264 0.324473120957349 3244 4749657
SGTC_784 4579-0127 173 µM -0.455515533985582 0.329127118026265 no 2265 0.32436919731391 3378 1948547
SGTC_3238 9133470 49.47 µM -0.457388807687064 0.328476550895846 no 2266 0.323695803796061 3321 3534688
SGTC_2004 4023728 41.89 µM -0.45826211774937 0.328173437496491 no 2267 0.32338206837393 3348 360084 YDR527W RBA50
SGTC_2943 9068529 45.32 µM -0.458569591273828 0.328066744755974 no 2268 0.323271638808581 3280 3270634
SGTC_2922 7999257 32.47 µM -0.45863310309119 0.328044708021308 no 2269 0.323248830386492 3294 2988377
SGTC_2044 5102272 200 µM -0.459022183204093 0.327909721720739 no 2270 0.323109118083874 3293 592666
SGTC_1827 berberine 7.24 µM -0.459856721713026 0.327620265238975 no 2271 0.322809533130854 3180 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_727 3032-0951 202 µM -0.46101144085349 0.327219926149799 no 2272 0.322395198441187 3241 3652836
SGTC_1914 st062367 72.6 µM -0.461667398872624 0.326992595119958 no 2273 0.322159926694677 3195 978205
SGTC_401 neomycin 50 µM -0.463415775645097 0.326386985466294 no 2274 0.321533186504773 3236 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2092 5303694 80.6725 µM -0.464396056299914 0.326047631985048 no 2275 0.321182007527922 3214 1963699
SGTC_2007 4011539 71.82 µM -0.464558587513968 0.325991380853138 no 2276 0.321123797249493 3209 45595301
SGTC_2051 5263410 176 µM -0.465033368486656 0.325827084532447 no 2277 0.32095378042557 3349 227584
SGTC_765 1319-0117 244 µM -0.465169211681118 0.325780082683662 no 2278 0.320905142523749 3210 3487746 YGL099W LSG1
SGTC_1464 k208-0027 110 µM -0.466335715668177 0.325376585463593 no 2279 0.320487608826457 3401 X1464
SGTC_2841 9004761 38.96 µM -0.467186273134644 0.325082504041519 no 2280 0.320183306863477 3223 2991039
SGTC_1667 st014849 34.6 µM -0.468064060646146 0.324779122009867 no 2281 0.319869389636292 3286 5348460
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.468421867169286 0.324655489788729 no 2282 0.319741466686469 3281 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2113 5491891 107.031 µM -0.468769206707261 0.32453549268253 no 2283 0.319617306399044 3260 789979
SGTC_2814 7977482 42.97 µM -0.469187855462186 0.324390884236014 no 2284 0.319467682724636 3336 6456762
SGTC_3256 9138902 49.47 µM -0.4702209028667 0.324034165297595 no 2285 0.319098600781154 3263 17228773
SGTC_416 estradiol valerate 100 µM -0.470617501333236 0.323897259790384 no 2286 0.318956953688899 3306 13791 A steroid.
SGTC_2037 5169046 200 µM -0.470976905525098 0.323773214292918 no 2287 0.318828613547123 3314 5718022
SGTC_3059 1327-0034 3 µM -0.471188716444242 0.323700118605013 no 2288 0.318752987864419 3226 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_617 3770-0098 35 µM -0.471399823905787 0.323627272445995 no 2289 0.318677620856308 3249 5962639
SGTC_1344 1488-0097 29.1 µM -0.472291811028635 0.323319552003056 no 2290 0.318359257328362 3323 747966
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.472535277778584 0.323235581082141 no 2291 0.318272383695311 3359 5377381
SGTC_471 1-acyl-paf 4 µM -0.473689962068524 0.322837456770779 no 2292 0.317860506229655 3223 16759367
SGTC_1297 1068-0111 14.1 µM -0.474383845810439 0.32259830975789 no 2293 0.317613105258421 3218 767057
SGTC_387 norethindrone acetate 66.7 µM -0.476271845201923 0.321947982457296 no 2294 0.316940360434362 3255 541197
SGTC_398 bronopol 33.3 µM -0.481014472457077 0.320316776723092 no 2295 0.315253106421534 3193 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2099 5377090 177.372 µM -0.481542447036747 0.320135396024949 no 2296 0.315065509595442 3320 2243829
SGTC_971 1315-0384 26.7 µM -0.481747178256413 0.320065074101954 no 2297 0.31499277853039 3260 6769120
SGTC_315 k915-0449 187 µM -0.482972149811397 0.319644450938715 no 2298 0.314557755532518 3309 20970215 YNL149C PGA2
SGTC_1876 myriocin 605 nM -0.485668842001993 0.318719295124373 no 2299 0.313600989147543 3395 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1502 4534-4282 27.7 µM -0.486873965852438 0.318306217115887 no 2300 0.313173824682739 3281 3278949
SGTC_2195 6536160 144.242 µM -0.487215238293507 0.318189280818206 no 2301 0.313052903814931 3230 3834386
SGTC_2242 6630449 61.2675 µM -0.487332340286488 0.31814916023647 no 2302 0.313011416451574 3357 691249 YDR170C SEC7
SGTC_3149 9097855 49.47 µM -0.487855308007772 0.317970011115306 no 2303 0.312826166253536 3359 25236625 YMR079W SEC14
SGTC_2143 5623677 140.463 µM -0.489381627891215 0.317447394847412 no 2304 0.312285770255043 3328 5375313
SGTC_3245 9134821 49.47 µM -0.489789862004738 0.317307675927091 no 2305 0.312141302667001 3255 17014901
SGTC_113 0099-0221 2.5 µM -0.489888378507921 0.317273962360207 no 2306 0.312106443562067 3416 89219
SGTC_1045 1348-1485 165 µM -0.492322716290319 0.316441384022846 no 2307 0.311245611882957 3295 6810614
SGTC_1144 3486-0183 12.5 µM -0.492880845003834 0.316250626843333 no 2308 0.311048391301536 3304 6744069
SGTC_1904 st060225 78 µM -0.493048002146864 0.316193505402454 no 2309 0.310989335141827 3342 66595
SGTC_3294 9122953 26.2835 µM -0.493458964607239 0.316053088727512 no 2310 0.310844163927387 3309 16459826
SGTC_1680 diphenhydramine 100 µM -0.493867341593435 0.315913581731568 no 2311 0.310699935183171 3259 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_497 capsazepine 133 µM -0.494302394287155 0.315764990798854 no 2312 0.310546317230814 3278 2733484 A calcium channel blocker.
SGTC_2992 9074591 71.4286 µM -0.494728469043961 0.315619495108501 no 2313 0.310395901421466 3380 17741321
SGTC_2600 tangeritin 87.95 µM -0.495712368603673 0.315283623025469 no 2314 0.31004867967206 3285 68077 A bioactive flavone.
SGTC_2349 9023730 187.07 µM -0.497227694000949 0.314766637595684 no 2315 0.309514247069967 3406 4126287
SGTC_1367 1812-0510 76.9 µM -0.497475199966895 0.314682230126734 no 2316 0.309426993635789 3313 1142582 YDR527W RBA50
SGTC_2516 gossypol 71.55 µM -0.4984760680785 0.314341000795899 no 2317 0.309074266566393 3408 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3036 9090181 49.47 µM -0.499586770303905 0.313962510993078 no 2318 0.308683037600427 3338 25236586
SGTC_630 4356-0227 183 µM -0.499841139736451 0.313875857999943 no 2319 0.308593470137638 3349 779312
SGTC_752 1896-0090 130 µM -0.500023186688529 0.313813848542592 no 2320 0.308529375544233 3356 772567
SGTC_147 4466-0538 29.23 µM -0.501388621271847 0.313348917265543 no 2321 0.308048823161092 3461 6742687 YHR072W ERG7
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.502095326692664 0.313108400034779 no 2322 0.307800233680082 3296 688664
SGTC_2190 6049624 200 µM -0.50255404565596 0.312952324040631 no 2323 0.307638922683551 3314 2265554
SGTC_907 3448-6986 75.5 µM -0.502834859672176 0.31285679552686 no 2324 0.307540191267501 3426 590582
SGTC_2942 9052777 62.25 µM -0.503478144407452 0.31263800754331 no 2325 0.307314071303975 3349 6469503
SGTC_1034 k072-0165 12.7 µM -0.50370631667549 0.312560419581277 no 2326 0.307233884432586 3405 5835461
SGTC_1939 st074455 53.6 µM -0.503977623316226 0.312468174968164 no 2327 0.307138550787148 3453 1644229
SGTC_2830 7992007 71.43 µM -0.505671591750902 0.311892489363762 no 2328 0.306543607147992 3285 1952075
SGTC_1038 k292-0204 154 µM -0.507303933614341 0.311338181620911 no 2329 0.305970789488029 3310 4454212
SGTC_1623 st003709 20.3 µM -0.507359161254105 0.311319434986665 no 2330 0.305951417417495 3285 16192618
SGTC_3213 9129884 49.47 µM -0.507806596884705 0.311167574149654 no 2331 0.305794491480341 3341 17190742
SGTC_782 0083-0095 30.5 µM -0.507875137272526 0.311144314198695 no 2332 0.305770455942746 3353 3591729 An indicator and reagent.
SGTC_2204 7233102 200 µM -0.507881729489607 0.311142077095493 no 2333 0.305768144247939 3280 2172480
SGTC_2973 9094665 17.96 µM -0.508029163978093 0.311092046256955 no 2334 0.305716445372509 3432 25237061 YIL048W NEO1
SGTC_2812 7970281 58.44 µM -0.508784427451903 0.310835807758811 no 2335 0.305451667998583 3409 2233435
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.510692297499752 0.310188932667929 no 2336 0.304783267531156 3291 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.511252355583151 0.309999152863549 no 2337 0.304587181088375 3412 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_423 5-fluorouracil 457 µM -0.512023883022927 0.309737797997931 no 2338 0.304317147351149 3204 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1671 st016596 74.5 µM -0.513679489225968 0.309177286187064 no 2339 0.3037380471838 3409 2829167
SGTC_1227 3909-8010 46.6 µM -0.513806570405682 0.30913428069466 no 2340 0.30369361688649 3297 15982272
SGTC_1674 st016616 23.6 µM -0.516964247943472 0.308066533356975 no 2341 0.302590558246785 3260 625830
SGTC_799 1310-0557 151 µM -0.516973234791982 0.308063496826181 no 2342 0.302587421471292 3430 5354492
SGTC_1527 coumarin 137 µM -0.519509143513566 0.307207174217629 no 2343 0.301702869183427 3428 323 A hepatotoxic, DNA x-linker.
SGTC_1980 st071811 45.7 µM -0.519799747870614 0.30710911027301 no 2344 0.301601577547847 3455 4974850
SGTC_2095 5432005 200 µM -0.521535088968047 0.30652380970798 no 2345 0.300997034206072 3298 783734
SGTC_193 1273-0060 1.558 µM -0.523198195959928 0.30596333518355 no 2346 0.300418168365303 3362 2847393 YHR072W ERG7
SGTC_2936 9038235 15.59 µM -0.523288912675268 0.305932776290043 no 2347 0.30038660771217 3346 4749415
SGTC_1336 1486-0901 104 µM -0.524411048169511 0.305554884732346 no 2348 0.299996336907979 3380 5006114
SGTC_3181 9108277 49.47 µM -0.524679817942889 0.305464404252412 no 2349 0.299902894745569 3306 17097298
SGTC_1467 k284-1082 293 µM -0.526222133516851 0.304945418515032 no 2350 0.299366938665974 3403 3334705
SGTC_2424 5537928 59.2 µM -0.526338977846938 0.304906116625747 no 2351 0.2993263528603 3334 5382802
SGTC_286 k060-0067 22.9 µM -0.527676853017823 0.304456267950621 no 2352 0.298861820750979 3343 5985051
SGTC_3258 9138477 49.47 µM -0.529814533156203 0.303738105697866 no 2353 0.298120263922768 3406 4970355
SGTC_345 1362-0200 395 µM -0.529941191055623 0.303695578197857 no 2354 0.29807635287533 3346 1419823
SGTC_205 1486-1330 71.903 µM -0.530925939225856 0.303365023290333 no 2355 0.297735050949684 3388 4118834
SGTC_2951 9072950 58.06 µM -0.531026584360051 0.303331248337056 no 2356 0.297700178595265 3437 16488155
SGTC_2728 chlorpromazine 9.18 µM -0.534004868948527 0.302332543755562 no 2357 0.296669082717365 3384 2726 A thorazine and dopamine antagonist.
SGTC_1320 1313-0481 95.3 µM -0.534258877683617 0.30224743561919 no 2358 0.296581219461756 3466 6813365 YLR208W SEC13
SGTC_635 k038-0028 24.7 µM -0.534288517410193 0.302237505236439 no 2359 0.296570967666364 3352 4035102
SGTC_2815 7968870 71.43 µM -0.534990830514521 0.302002247740041 no 2360 0.296328098962554 3381 2977326 YHR190W ERG9
SGTC_3281 9140613 49.47 µM -0.535473968772494 0.301840456156587 no 2361 0.296161076641895 3365 16013766
SGTC_294 k038-0071 157 µM -0.536006418271883 0.301662196538493 no 2362 0.295977057324645 3399 24152826
SGTC_3122 9126309 49.47 µM -0.536351973941588 0.301546532743393 no 2363 0.295857658285179 3439 17591206
SGTC_1125 tnp00248 1.32998 µM -0.536475798162805 0.301505091370891 no 2364 0.295814878977217 3458 24207736
SGTC_334 1502-1024 68.5 µM -0.53663018392386 0.301453425281182 no 2365 0.295761545121449 3439 3296216
SGTC_375 3970-0961 9.27 µM -0.536901071273308 0.30136278089048 no 2366 0.295667975493331 3351 2898222
SGTC_2870 9038528 12.99 µM -0.537802304922433 0.301061298231222 no 2367 0.295356770271954 3434 6463316
SGTC_520 3584-0023 682 µM -0.538756015299102 0.30074240906508 no 2368 0.295027608529049 3355 1340790
SGTC_709 3807-1509 243 µM -0.539336567692655 0.300548366230942 no 2369 0.294827320583754 3438 1886677 YPL242C IQG1
SGTC_321 4534-3890 65.3 µM -0.541375624027896 0.299867283986416 no 2370 0.294124352572189 3416 699746
SGTC_2111 5486399 200 µM -0.542502605198528 0.299491151638213 no 2371 0.293736156623774 3417 689674
SGTC_2962 9082311 13.18 µM -0.542912906033927 0.299354265992388 no 2372 0.293594884746222 3310 16459453
SGTC_861 0443-0273 110 µM -0.543101836420355 0.299291244081777 no 2373 0.293529844153097 3405 6149169
SGTC_328 k915-0120 63.5 µM -0.547181897161997 0.297931720705851 no 2374 0.29212688592444 3434 6624543
SGTC_1752 st044819 83.042 µM -0.549302507349636 0.297226222615313 no 2375 0.2913989334744 3344 441209 YML126C ERG13
SGTC_529 4076-0302 30.3 µM -0.550279560776232 0.296901427411138 no 2376 0.291063820509595 3348 5816522
SGTC_2664 lyso-paf C-16 73.48 µM -0.551204106035369 0.296594236771859 no 2377 0.290746882829009 3385 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3234 9132280 49.47 µM -0.551248826260233 0.29657938166262 no 2378 0.290731556656088 3447 17612295
SGTC_2468 5987765 72.9 µM -0.552423928059587 0.296189160005606 no 2379 0.290328970231302 3383 26772094
SGTC_3326 9140064 16.379 µM -0.552643982981065 0.296116111510352 no 2380 0.290253609092799 3372 1868434
SGTC_1568 digitonin 820 nM -0.552778425200466 0.296071486711902 no 2381 0.290207571829517 3500 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3098 9119039 49.47 µM -0.553912766974503 0.29569509271382 no 2382 0.289819273636884 3451 17161528
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.554405606424802 0.295531628710846 no 2383 0.289650645027337 3446 140250 A respiratory chain inhibitor.
SGTC_2902 5787006 60.46 µM -0.556497139838076 0.294838375896994 no 2384 0.288935524575006 3360 591003
SGTC_2990 9074105 71.4286 µM -0.557719282322133 0.29443363585481 no 2385 0.288518044267116 3424 6502001
SGTC_103 0844-0104 51.839 µM -0.557858463820217 0.294387559035579 no 2386 0.2884705183077 3508 5375804
SGTC_2696 st077691 74.316 µM -0.560563110943596 0.293492832062806 no 2387 0.287547702520341 3462 757133
SGTC_1470 k295-0292 231 µM -0.560899308347176 0.293381702335823 no 2388 0.28743309078325 3477 5045612
SGTC_2390 9097792 176.6 µM -0.56100983636394 0.293345171665621 no 2389 0.28739541583072 3374 4497149
SGTC_410 α-linolenic acid 100 µM -0.56133605729512 0.293237364515667 no 2390 0.287284232687512 3487 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1417 3966-0327 90.4 µM -0.561658298920576 0.293130890453817 no 2391 0.287174425764623 3438 651118
SGTC_2080 5212524 12.4 µM -0.561697717143625 0.293117867239647 no 2392 0.287160994991205 3467 260183
SGTC_999 SEC7.066 22.7 µM -0.562041174123476 0.293004405348035 no 2393 0.287043983202291 3426 740511 YDR170C SEC7
SGTC_1815 st051655 58.2 µM -0.564651656280779 0.292142692662847 no 2394 0.286155361245996 3437 5984156
SGTC_1936 st074407 74.3 µM -0.565386174049492 0.29190044322156 no 2395 0.285905563280996 3385 809813
SGTC_1373 2887-0003 58.5 µM -0.568568895324831 0.2908518405568 no 2396 0.284824369270421 3404 776948
SGTC_1399 3562-5772 25 µM -0.569152749528388 0.290659670976667 no 2397 0.284626241636306 3429 23847490
SGTC_1849 st056239 19.2 µM -0.576046218042592 0.288395260214288 no 2398 0.282291971136036 3375 5393181
SGTC_2221 6807166 181.081 µM -0.576938020141715 0.288102923937166 no 2399 0.281990662801107 3444 674925
SGTC_354 2783-3500 4.88 µM -0.577235475679103 0.288005447936613 no 2400 0.281890197574201 3407 6740761
SGTC_445 e6 berbamine 66 µM -0.577351535959858 0.287967419275052 no 2401 0.281851003040593 3486 6610268 A calcium/calmodulin antagonist.
SGTC_2357 9067248 200 µM -0.578595380649681 0.2875600062957 no 2402 0.281431111188665 3468 9150235
SGTC_900 1112-0045 141 µM -0.578638055609359 0.287546033235404 no 2403 0.281416710512847 3438 56211 YIL048W NEO1
SGTC_1970 st070122 35.8 µM -0.579323073657197 0.287321781749171 no 2404 0.28118559967989 3560 102928
SGTC_2183 6420625 130.508 µM -0.580048865261172 0.287084272715466 no 2405 0.280940832746037 3517 2897619
SGTC_1306 1185-0270 9.02 µM -0.580738587749221 0.286858653177308 no 2406 0.280708325279134 3495 1548076
SGTC_1965 Pectolinarigenin 58.4 µM -0.580867934685975 0.286816351031229 no 2407 0.280664732414633 3438 5320438 An anti-inflammatory.
SGTC_3268 9137683 49.47 µM -0.581629032671852 0.286567498364928 no 2408 0.280408291404067 3463 1953228
SGTC_742 0kpi-0133 140 µM -0.582655061322418 0.286232184743892 no 2409 0.280062765468822 3502 2728852
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.583265549144211 0.286032761339567 no 2410 0.279857275248478 3447 1241132 A phosphatase inhibitor.
SGTC_1412 3909-8563 178 µM -0.583833632953722 0.285847249058163 no 2411 0.2796661239305 3549 23767530
SGTC_1203 3992-3522 103 µM -0.586720124692904 0.28490552722259 no 2412 0.278695844756119 3667 5322312
SGTC_1251 0490-5699 265 µM -0.58688128714337 0.284852991406377 no 2413 0.2786417191818 3551 3883818
SGTC_1860 st056228 74.6 µM -0.587453006731927 0.284666659258322 no 2414 0.278449751416277 3483 688679
SGTC_1986 st071812 45 µM -0.587638584242154 0.28460618922424 no 2415 0.278387453431722 3482 11838594
SGTC_852 0418-0143 439 µM -0.58794339826102 0.284506879542219 no 2416 0.278285142742551 3517 5369229
SGTC_2597 laccaic acid a 100 µM -0.591481825822756 0.283355258061867 no 2417 0.277098814435543 3469 5491415 A textile dye.
SGTC_644 1498-1197 63.3 µM -0.593056007667831 0.282843642038322 no 2418 0.276571835215167 3536 6741615
SGTC_513 4245-1575 41.7 µM -0.593587985230082 0.282670847348403 no 2419 0.2763938594704 3481 719745
SGTC_3356 9151811 4.48 µM -0.594736247138837 0.282298046821073 no 2420 0.276009894311872 3448 1859254 YPR165W RHO1
SGTC_772 k072-0172 35.3 µM -0.595556983416952 0.282031727483524 no 2421 0.275735610456306 3440 5861980
SGTC_2954 9074818 52.69 µM -0.597062540950338 0.28154350643461 no 2422 0.275232813057969 3515 16648742
SGTC_1701 st028638 40.4 µM -0.597378459133876 0.281441112497045 no 2423 0.275127366046214 3521 3490878
SGTC_2694 st077685 81.9 µM -0.598536946558252 0.281065782760784 no 2424 0.274740857023511 3471 2838096
SGTC_959 1222-0044 107 µM -0.598602761392593 0.281044467162755 no 2425 0.274718907097023 3513 6083612
SGTC_955 1216-0110 33 µM -0.598629964206381 0.281035657154564 no 2426 0.274709834930451 3488 3619719
SGTC_396 dithiazanine 1.25 µM -0.601348304016883 0.280155958707535 no 2427 0.273804011499593 3442 10578 An antihelmenthic.
SGTC_3140 9094243 49.47 µM -0.601762918498859 0.280021900165991 no 2428 0.273665980814679 3566 19291112
SGTC_2141 5621638 7.665 µM -0.603236149020817 0.279545807849401 no 2429 0.273175801404363 3543 2856238
SGTC_3341 9147222 25.867 µM -0.603952545086346 0.279314437874494 no 2430 0.27293759642437 3509 1939759
SGTC_1087 pterostilbene 9.05 µM -0.605593644593397 0.278784773160504 no 2431 0.272392311816403 3555 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2575 plumbagin 510 nM -0.606111968873384 0.278617585689325 no 2432 0.272220201831851 3485 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2683 piperine 63.03 µM -0.606484261474716 0.278497531429696 no 2433 0.272096615139925 3462 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3085 9117376 49.47 µM -0.607094126326561 0.278300921039497 no 2434 0.27189422397754 3544 16480349
SGTC_2094 5332512 191.667 µM -0.608285023541972 0.277917190555592 no 2435 0.271499226102859 3553 755774
SGTC_2787 5284540 71.43 µM -0.610678802741603 0.277146649989246 no 2436 0.270706120908394 3506 736958
SGTC_446 go6976 132 µM -0.611080193132507 0.277017547673503 no 2437 0.270573245876166 3511 3501 A protein kinase C inhibitor.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.612547403525962 0.276545887995308 no 2438 0.270087822459509 3505 6708561
SGTC_1578 josamycin 24.2 µM -0.61281785804379 0.276458988793884 no 2439 0.269998390741673 3465 5282165 A P450 substrate.
SGTC_3078 9116413 49.47 µM -0.613001194959203 0.276400088791546 no 2440 0.269937774798322 3487 17177322
SGTC_2580 diallyl disulphide 81.36 µM -0.615378958846078 0.275636751019316 no 2441 0.269152241870417 3513 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1691 st019933 84.6 µM -0.616089989672999 0.275408689005307 no 2442 0.268917564244368 3524 6176082
SGTC_760 0568-0725 82.9 µM -0.616286880691559 0.275345552940214 no 2443 0.268852598004888 3552 3916171
SGTC_3075 9116269 49.47 µM -0.61636656004814 0.275320004581277 no 2444 0.268826309212807 3578 17015205 YNL244C SUI1
SGTC_1384 3089-0840 101 µM -0.618222471349297 0.274725256159837 no 2445 0.268214349629313 3529 1069836
SGTC_33 0986-0033 35.816 µM -0.623018733171935 0.273191178351701 no 2446 0.266636105783232 3511 2848082
SGTC_2695 st077686 51.995 µM -0.623236123414405 0.273121747054892 no 2447 0.266564683375029 3519 2876092
SGTC_1682 st012968 530 nM -0.623412940692514 0.273065280625402 no 2448 0.266506598134139 3449 24207270
SGTC_2659 sanguinarine 24.21 µM -0.623639613180294 0.272992901446966 no 2449 0.266432144606027 3502 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2260 7964312 200 µM -0.623730255404897 0.272963960986165 no 2450 0.266402374933417 3601 231951
SGTC_1523 st012844 44.7 µM -0.623765633448077 0.272952665814803 no 2451 0.266390756161065 3552 4274103
SGTC_2431 5490079 200 µM -0.624479849381165 0.272724687197057 no 2452 0.266156249920546 3537 5722345
SGTC_145 3737-0113 38.366 µM -0.625035282372436 0.272547457626563 no 2453 0.26597395087885 3596 6849351
SGTC_21 0849-0113 22.993 µM -0.626418936648023 0.272106205000251 no 2454 0.265520095991952 3534 1560156
SGTC_629 3448-6466 76.7 µM -0.629034035049109 0.271273211288121 no 2455 0.264663387227943 3573 573744
SGTC_1179 1021-1431 9.29 µM -0.632259043347311 0.270247694806964 no 2456 0.263608810795561 3532 2840958
SGTC_682 0kpi-0099 17 µM -0.6322654808788 0.270245649684406 no 2457 0.263606707871386 3579 1714895 YML126C ERG13
SGTC_2081 5214970 32.255 µM -0.63306134347187 0.269992873811104 no 2458 0.263346792390777 3543 2063512
SGTC_3007 9078383 71.4286 µM -0.635257227563633 0.269296047828469 no 2459 0.262630332428097 3548 6496995
SGTC_1007 4101-0031 70 µM -0.636012428474711 0.269056606433303 no 2460 0.262384160679692 3563 1146276
SGTC_981 1488-1094 54.9 µM -0.636812140870622 0.268803168911479 no 2461 0.262123608457331 3568 3449522
SGTC_2135 5326629 150.42 µM -0.636998117521916 0.268744248084682 no 2462 0.262063034895207 3538 5020077
SGTC_93 0109-0045 59.227 µM -0.638186077078103 0.268368033778295 no 2463 0.261676279652039 3643 88733
SGTC_215 1287-0124 461.5 µM -0.638717050604313 0.268199965736235 no 2464 0.26150350927307 3561 5560863
SGTC_1925 st057770 10.1 µM -0.638738178250933 0.268193279338156 no 2465 0.261496635883078 3476 5989122
SGTC_756 0508-1999 28.3 µM -0.639187099726963 0.268051226188566 no 2466 0.261350611615977 3501 6753853
SGTC_860 0443-0016 25.1 µM -0.639954007805327 0.267808639538302 no 2467 0.261101250239821 3593 5337942
SGTC_2903 5923464 63.88 µM -0.640148464074046 0.267747147147953 no 2468 0.261038041917685 3616 2876576
SGTC_2473 5854593 8.94 µM -0.641172162727516 0.267423542994546 no 2469 0.260705416794035 3529 2872951
SGTC_2928 9011484 9.79 µM -0.64180036109211 0.267225059225897 no 2470 0.260501407586299 3566 2994751
SGTC_2733 amorolfine 100 µM -0.642675522237414 0.26694866979068 no 2471 0.260217333606453 3589 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1218 1348-1416 30.7 µM -0.642949234820995 0.266862256772135 no 2472 0.260128520327305 3581 6787668
SGTC_1636 st007707 68.9 µM -0.643898467837627 0.266562686660313 no 2473 0.259820637701233 3627 403051
SGTC_871 0574-0004 149 µM -0.644390012285878 0.266407626146001 no 2474 0.259661279751315 3537 9551173
SGTC_101 0490-5701 117.494 µM -0.645095531582216 0.266185145824686 no 2475 0.259432639696047 3526 4661669
SGTC_2445 5742597 35.57 µM -0.64602926542715 0.265890844420079 no 2476 0.259130201339877 3542 1774255
SGTC_1545 lovastatin 49.4 µM -0.646898910046169 0.265616891523613 no 2477 0.258848685649526 3607 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2649 anisomycin 9.56 µM -0.646972475019807 0.265593723869874 no 2478 0.25882487893694 3562 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1954 st077032 68.9 µM -0.647775991161021 0.265340741066531 no 2479 0.258564923030521 3532 698907
SGTC_2655 perillic acid 100 µM -0.64805214014159 0.265253825271079 no 2480 0.258475613728227 3564 5702197 An apoptosis inducer.
SGTC_559 1550-0661 158 µM -0.648202026180754 0.265206655830648 no 2481 0.258427145796647 3595 5830875
SGTC_2234 tolnaftate 200 µM -0.648343430460433 0.265162159521968 no 2482 0.258381424887645 3562 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1416 3966-0321 25.3 µM -0.648440780106367 0.265131528282994 no 2483 0.258349950806063 3592 582530 YLR208W SEC13
SGTC_2927 9011802 47.9 µM -0.648668591692658 0.265059853987125 no 2484 0.258276304882939 3575 43912568
SGTC_1837 st055472 66.5 µM -0.64972426039496 0.26472784704374 no 2485 0.257935175056917 3658 676091
SGTC_1600 coumarin 106 71.1 µM -0.650640525034283 0.264439854087271 no 2486 0.257639281996933 3640 100336 A hepatotoxic, DNA x-linker.
SGTC_2875 9039966 71.43 µM -0.651067604602111 0.264305672364764 no 2487 0.257501423704249 3604 6463691
SGTC_512 prima-1 270 µM -0.651236411420919 0.264252645462305 no 2488 0.25744694461337 3605 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2717 st081029 62.2815 µM -0.652120195163953 0.263975112940339 no 2489 0.257161818512754 3570 5292846
SGTC_1441 4106-0040 13 µM -0.652236683914035 0.263938543336932 no 2490 0.257124249190852 3598 2904180
SGTC_1540 guanosine 70.6 µM -0.652410710551416 0.263883915532149 no 2491 0.257068128378019 3555 6802 Guanosine is a purine nucleoside
SGTC_1507 4075-3230 155 µM -0.654645920940187 0.263182784986438 no 2492 0.256347875511329 3535 659771
SGTC_1702 st027038 51 µM -0.655041561295044 0.263058781540386 no 2493 0.256220497783861 3601 5521182
SGTC_1911 st060208 74.3 µM -0.65562324811427 0.262876520780195 no 2494 0.256033281720291 3604 688783
SGTC_869 0564-0080 44.1 µM -0.655728940713168 0.262843410900957 no 2495 0.255999272190726 3565 6843321
SGTC_2933 9026794 32.47 µM -0.657171703455635 0.262391655982827 no 2496 0.255535258976676 3594 17586027
SGTC_366 0181-0206 4.31 µM -0.657559157439949 0.262270404941981 no 2497 0.255410723092554 3627 274874
SGTC_128 0906-2981 13.371 µM -0.658994571588192 0.261821452288359 no 2498 0.254949627263019 3596 6740226
SGTC_2467 5474540 200 µM -0.661071727355815 0.26117248158003 no 2499 0.254283157811992 3605 5413519
SGTC_1999 st074831 12.5 µM -0.661489281455616 0.261042124024892 no 2500 0.254149293106926 3598 17112523
SGTC_3148 9097893 49.47 µM -0.661997989560905 0.260883354021074 no 2501 0.253986255070449 3544 17174100
SGTC_1131 3454-3128 32.3 µM -0.662382486188924 0.260763383923935 no 2502 0.253863062526805 3631 710982
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.662763029555239 0.260644675274246 no 2503 0.253741167495359 3685 688664
SGTC_942 3253-1115 227 µM -0.663899413377369 0.260290351499849 no 2504 0.253377345874191 3659 46497897
SGTC_3287 9117173 37.0625 µM -0.666742935047643 0.25940483192096 no 2505 0.252468174384144 3586 2789709
SGTC_31 0508-1974 57.237 µM -0.668824192673502 0.258757681740388 no 2506 0.251803816131886 3591 6810525
SGTC_1480 1070-0044 41.2 µM -0.66906502735536 0.258682850125186 no 2507 0.251726998918279 3615 3124987
SGTC_3121 9125696 49.47 µM -0.670030634207812 0.258382931460984 no 2508 0.251419130935779 3672 1235365
SGTC_503 tyrphostin 8 294 µM -0.670410454808597 0.258265008111061 no 2509 0.251298085895216 3603 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3026 9090633 49.47 µM -0.673236215316277 0.257388567450071 no 2510 0.250398512360148 3620 25236842
SGTC_3180 9109287 49.47 µM -0.674294151354305 0.257060835036531 no 2511 0.250062160829495 3623 18891271
SGTC_668 1682-0499 62.6 µM -0.676266180011083 0.256450510562621 no 2512 0.249435830575389 3658 682214
SGTC_2310 7668677 200 µM -0.67627877418756 0.256446615210164 no 2513 0.249431833256903 3668 2197143
SGTC_3001 9076041 71.4286 µM -0.676725403534905 0.256308493621465 no 2514 0.249290097710183 3647 16004211
SGTC_1058 3448-5425 97.3 µM -0.677486882913053 0.256073093073583 no 2515 0.249048544886563 3580 7279705
SGTC_1207 2099-0101 141 µM -0.677556175354771 0.256051677897165 no 2516 0.249026570454697 3656 5837381
SGTC_3224 9130643 49.47 µM -0.677902048346288 0.255944798086421 no 2517 0.24891690057929 3674 17644395
SGTC_1754 st042065 16.137 µM -0.678517089739385 0.255754798821901 no 2518 0.248721945938552 3602 1126236 YIL048W NEO1
SGTC_532 1548-0774 215 µM -0.679508402700819 0.255448716389156 no 2519 0.248407892682087 3741 5932993
SGTC_420 mitomycin C 81.9 mM -0.680402553678405 0.255172798421857 no 2520 0.248124802259126 3641 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1068 loratadine 26.9 µM -0.680811506681801 0.255046655271864 no 2521 0.247995384095327 3643 3957 A H1 histamine antagonist.
SGTC_1053 3366-3204 134 µM -0.681767339388621 0.254751952216255 no 2522 0.24769303971125 3626 3632071 YPR165W RHO1
SGTC_3292 9120825 59.784 µM -0.682227322909497 0.254610193323618 no 2523 0.247547610136531 3667 24824900
SGTC_3212 9128307 49.47 µM -0.68223471023166 0.254607917017018 no 2524 0.247545274913982 3605 27243542
SGTC_1511 0906-3109 28.5 µM -0.682889663166555 0.254406144219915 no 2525 0.247338283096 3697 2882180
SGTC_794 k038-0031 316 µM -0.683752758072095 0.254140376703522 no 2526 0.247065651295563 3682 6624242
SGTC_901 1112-0062 60.1 µM -0.68516048114203 0.253707217814904 no 2527 0.24662132916221 3657 1908457
SGTC_2366 9070441 60.58 µM -0.687063563984531 0.253122252754267 no 2528 0.246021336796028 3653 6837235
SGTC_1921 5740136 50 µM -0.687479981654301 0.25299434995042 no 2529 0.245890155672768 3646 1774243
SGTC_1888 azatryptophan 97.5 µM -0.688066158566419 0.252814363192633 no 2530 0.245705560125077 3621 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1771 st048882 4.1505 µM -0.688146696081191 0.25278963926082 no 2531 0.245680203517833 3643 4580403
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.688328845909324 0.252733726413695 no 2532 0.245622860251034 3667 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2975 9084847 53.72 µM -0.690443128653264 0.252085201392046 no 2533 0.244957781301222 3677 27211724
SGTC_65 0798-0905 34.986 µM -0.691525622420192 0.251753502531137 no 2534 0.244617642273366 3765 3602145
SGTC_1826 st055655 41.6 µM -0.695261757299024 0.250610444934874 no 2535 0.243445637947176 3699 676168
SGTC_1021 4476-0760 85.3 µM -0.695950207472711 0.250400116353467 no 2536 0.243230006527142 3667 746768
SGTC_466 geldanamycin 89.2 µM -0.696328159314043 0.250284687988374 no 2537 0.243111671079739 3567 5288382 HSP90 inhibitor.
SGTC_610 4215-0184 155 µM -0.69684757862531 0.250126100797106 no 2538 0.242949093449881 3688 5605015
SGTC_519 k048-0011 62.8 µM -0.696954674563749 0.250093409288824 no 2539 0.24291557986317 3688 6836379
SGTC_1393 3470-5649 58.2 µM -0.697357473613794 0.249970473397103 no 2540 0.242789554148607 3618 4108395
SGTC_1377 2944-0135 198 µM -0.697445385546591 0.249943646585273 no 2541 0.242762053416143 3728 1894137
SGTC_2231 micatex 6.853 µM -0.698593757316055 0.24959335498438 no 2542 0.242402973079279 3689 20737 An antifungal of unknown mechanism.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.698656795640585 0.249574133751684 no 2543 0.242383270181988 3651 75037 A free radical scavenger.
SGTC_1075 aripiprazole 15.2 µM -0.700530501355778 0.249003174931694 no 2544 0.241798031849389 3705 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1907 st060210 83.7 µM -0.702742721402079 0.248329959213687 no 2545 0.241108049351298 3697 688793
SGTC_3202 9113761 49.47 µM -0.703275299488781 0.248168031794497 no 2546 0.240942100410587 3731 4798415
SGTC_1365 1672-3266 55.4 µM -0.704034400506783 0.247937328702659 no 2547 0.240705675360963 3681 6415873
SGTC_175 3793-3120 23.7 µM -0.70714417443197 0.246993414153114 no 2548 0.239738443294339 3694 5322297
SGTC_1078 idebenone 36.1 µM -0.708030403389895 0.246724768177919 no 2549 0.23946318858095 3716 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_94 0334-0113 514.748 µM -0.709161568310068 0.246382101255385 no 2550 0.239112109820105 3659 6795178
SGTC_287 k060-0039 29.6 µM -0.709821606444231 0.246182271979392 no 2551 0.238907384349496 3719 5861974
SGTC_963 1269-2853 151 µM -0.70993032020892 0.246149366775879 no 2552 0.238873673560274 3686 3668223
SGTC_92 0063-0024 660.874 µM -0.711283042396433 0.245740125641989 no 2553 0.238454428852457 3752 3594437
SGTC_1256 0570-0116 285 µM -0.711617026381821 0.24563914121118 no 2554 0.238350980349525 3700 410638
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.711750847634057 0.245598684858379 no 2555 0.238309537331494 3691 4330530
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.711791389444238 0.245586429112608 no 2556 0.238296982743249 3726 23665772 A membrane-active detergent.
SGTC_628 1636-0253 16 µM -0.711874685831035 0.245561249734992 no 2557 0.238271189475901 3692 4456143
SGTC_1334 1486-0610 236 µM -0.712533476999288 0.245362154888949 no 2558 0.238067244399657 3729 3742339
SGTC_992 3909-8734 162 µM -0.712643951557678 0.245328776606083 no 2559 0.23803305364136 3708 4288319
SGTC_3154 9100113 49.47 µM -0.713206894588569 0.245158729459624 no 2560 0.237858870276491 3706 25237525
SGTC_2813 7971799 71.43 µM -0.713543045347239 0.24505721926233 no 2561 0.237754893321658 3736 2234054
SGTC_2102 5377816 72.7585 µM -0.715038189945393 0.244605992253805 no 2562 0.237292722724765 3707 1379702
SGTC_3031 9088762 49.47 µM -0.717225173645929 0.243946778512525 no 2563 0.236617584366796 3683 205253
SGTC_1130 3454-2858 15.9 µM -0.71742529265173 0.243886505346086 no 2564 0.236555858940627 3725 715628 YIL048W NEO1
SGTC_2961 9083290 32.55 µM -0.717675118473726 0.243811272431221 no 2565 0.236478814201572 3672 17741490
SGTC_1112 tnp00069 1.16933 µM -0.717793294049142 0.243775689229331 no 2566 0.236442374396724 3756 145826
SGTC_1760 st045453 10.4495 µM -0.717858928376407 0.243755927646485 no 2567 0.236422137183582 3724 3323419 YIL048W NEO1
SGTC_218 alverine citrate 93.75 µM -0.718118647717296 0.243677738248142 no 2568 0.236342066554764 3713 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2212 7123476 200 µM -0.719415370728243 0.243287558007569 no 2569 0.235942514512056 3659 1085715
SGTC_2385 9074692 200 µM -0.719504941701164 0.24326061883217 no 2570 0.235914929259203 3719 17046906
SGTC_144 4161-2749 112.381 µM -0.719937818984451 0.243130450309335 no 2571 0.235781640711767 3631 797501 YMR168C CEP3
SGTC_1235 benzylparaben 21.5 µM -0.721488116183065 0.242664576758982 no 2572 0.235304624841936 3689 7180
SGTC_3135 9127742 49.47 µM -0.722095879099352 0.242482072339345 no 2573 0.235117765812161 3751 3643468
SGTC_2371 9071574 200 µM -0.723799227321738 0.241970972308339 no 2574 0.234594501892984 3682 45596039
SGTC_2370 9071495 200 µM -0.72531902989412 0.241515440006654 no 2575 0.234128166932858 3673 21791103
SGTC_1755 st041960 45.185 µM -0.725740827006525 0.241389096852424 no 2576 0.233998834117384 3741 2257073
SGTC_3166 9102297 49.47 µM -0.726076728546275 0.241288508148574 no 2577 0.233895867197723 3687 25237072
SGTC_983 1491-0821 12.2 µM -0.727306484901023 0.240920441089748 no 2578 0.23351911320525 3697 46495113
SGTC_539 4859-0462 2.54 µM -0.728235298724401 0.240642648938218 no 2579 0.233234780648457 3759 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3275 9138069 49.47 µM -0.729349405935433 0.240309668872273 no 2580 0.232893978891034 3798 17617007
SGTC_1634 st006576 41 µM -0.729675577434072 0.240212231518593 no 2581 0.232794256469724 3697 3915356
SGTC_2687 chenodiol 100 µM -0.730130503663019 0.240076367172518 no 2582 0.232655208704322 3729 5702181 A cholesterol synthesis inhibitor.
SGTC_2130 NSC 7 2.4545 µM -0.730200183461893 0.240055560904822 no 2583 0.232633915218449 3749 21448
SGTC_725 1497-0963 19 µM -0.730227822488594 0.240047308211469 no 2584 0.23262546929404 3748 3549977
SGTC_1982 st072467 71.9 µM -0.732652850103939 0.239323825556684 no 2585 0.231885094111495 3713 3163533
SGTC_2481 5478948 45.16 µM -0.734320344483001 0.238827037284802 no 2586 0.231376760714316 3742 77792
SGTC_2853 9015042 58.44 µM -0.73496496435285 0.238635140189682 no 2587 0.231180415906341 3682 6457456
SGTC_1002 4049-0206 172 µM -0.736972009441289 0.238038203014855 no 2588 0.230569685641182 3761 4662749
SGTC_807 1315-0151 48 µM -0.738607203601823 0.237552467765867 no 2589 0.230072774364119 3737 4011080
SGTC_200 k038-0079 37.545 µM -0.740069270837266 0.237118621001624 no 2590 0.22962898167374 3692 3436683
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.740360359484366 0.237032296759047 no 2591 0.229540682537196 3755 5282362
SGTC_57 miconazole 162.5 nM -0.741073043969775 0.236821018439318 no 2592 0.229324576403513 3671 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_51 1013-0126 23.419 µM -0.742509988993424 0.236395345086531 no 2593 0.228889200968104 3793 1627850
SGTC_383 2324-0395 7.37 µM -0.74380630963795 0.236011691253158 no 2594 0.228496831202333 3775 3146421
SGTC_1471 k673-0312 37 µM -0.744405363318909 0.235834513719659 no 2595 0.228315637629329 3736 24099884
SGTC_2020 4017018 200 µM -0.74472533376506 0.235739908555104 no 2596 0.228218890436043 3818 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2276 7947513 42.08 µM -0.745226608521345 0.235591739510075 no 2597 0.228067369890509 3639 2105100
SGTC_623 k072-0108 16.9 µM -0.745539161001074 0.235499379852385 no 2598 0.227972923154757 3748 5382803
SGTC_1063 disulfiram 1.84 µM -0.745823051140116 0.235415507270556 no 2599 0.227887156641813 3750 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2420 aureobasidin a 50 nM -0.746528838038913 0.235207060850945 no 2600 0.22767400890266 3797 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1648 st011736 69.8 µM -0.748423692844745 0.23464794070663 no 2601 0.227102317973308 3766 2855514
SGTC_3286 9117135 37.221 µM -0.749658067484628 0.234284106026727 no 2602 0.226730334258767 3746 3438150
SGTC_2767 sibutramine 71.45 µM -0.750231236914125 0.234115269280529 no 2603 0.22655772432484 3779 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_572 0960-0087 17.7 µM -0.75098483241067 0.233893387553108 no 2604 0.226330892021438 3777 6796365
SGTC_6 0844-0013 19.835 µM -0.751338074309921 0.233789422379193 no 2605 0.22622461035619 3852 1584900
SGTC_2893 9048488 25.97 µM -0.751561005918961 0.23372382295251 no 2606 0.226157550318792 3753 6467338
SGTC_843 0310-0051 143 µM -0.752901757336709 0.233329511305834 no 2607 0.22575447602217 3787 2065037
SGTC_1386 3228-0095 33.8 µM -0.753427834228117 0.233174894298433 no 2608 0.225596430952972 3748 870181
SGTC_2411 st077133 39.94 µM -0.754494325483968 0.232861621012245 no 2609 0.225276225724138 3877 1403142 YNL221C POP1
SGTC_3074 9116018 49.47 µM -0.755400596093976 0.232595595138728 no 2610 0.225004327841101 3802 17027303
SGTC_440 fluspirilene 35.1 µM -0.756320734488432 0.232325671472157 no 2611 0.224728459737362 3881 3396 An atypical antipsychotic.
SGTC_3123 9126162 49.47 µM -0.757254010419643 0.232052072001278 no 2612 0.224448848894066 3846 25239884
SGTC_3090 9117696 49.47 µM -0.757593590894073 0.231952565006793 no 2613 0.224347159092866 3718 7923821
SGTC_1621 st003705 32.4 µM -0.758017993903169 0.231828235945094 no 2614 0.224220105352295 3782 24207032
SGTC_378 3970-0959 8.33 µM -0.759068370414508 0.231520687339295 no 2615 0.22390582936862 3795 6615653
SGTC_3284 9108171 64.8615 µM -0.759087070451803 0.231515214059018 no 2616 0.223900236527031 3755 8687505
SGTC_2030 5175110 200 µM -0.759145426442036 0.231498134413003 no 2617 0.223882783820456 3804 2831986
SGTC_2603 homopterocarpin 100 µM -0.759768647850285 0.231315773631007 no 2618 0.223696443289687 3819 101795 A weak amylase inhibitor.
SGTC_1259 0671-0132 43 µM -0.760169945355616 0.231198392410328 no 2619 0.223576503740526 3729 X1259
SGTC_541 4513-1321 94 µM -0.760401771140767 0.231130597533582 no 2620 0.22350723246427 3780 747515
SGTC_3113 9123498 49.47 µM -0.761102316708128 0.230925798188674 no 2621 0.223297978420251 3803 8897275
SGTC_1696 st025591 34.7925 µM -0.761578463982943 0.23078665788917 no 2622 0.223155816161134 3764 2787147
SGTC_1371 2421-0008 32.7 µM -0.762545153746444 0.230504314791303 no 2623 0.222867352254682 3764 2827552
SGTC_1494 4358-1428 177 µM -0.762594063244962 0.230490034824859 no 2624 0.222852763122445 3783 1564571
SGTC_1909 st060837 51.5 µM -0.762717846936269 0.23045389626388 no 2625 0.222815842324176 3800 678937
SGTC_221 trifluoperazine 10.304 µM -0.76293704418464 0.230389909553678 no 2626 0.222750471201474 3766 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1440 4100-1550 40 µM -0.763073070741801 0.230350206514356 no 2627 0.222709909543013 3783 742806
SGTC_3274 9138298 49.47 µM -0.763582932417372 0.230201423607628 no 2628 0.222557911733775 3749 17015756
SGTC_1773 st048542 73.5835 µM -0.763643045196497 0.230183885620435 no 2629 0.222539995064599 3732 3237138
SGTC_1231 0242-0792 125 µM -0.763998397585436 0.230080226334782 no 2630 0.222434098759723 3781 3707635
SGTC_2409 alverine citrate 63.97 µM -0.764158214895743 0.230033614795396 no 2631 0.2223864819907 3954 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.765202815642959 0.229729081802971 no 2632 0.222075391656392 3824 279621
SGTC_3320 9137005 35.139 µM -0.767234256013921 0.229137501927647 no 2633 0.221471124545805 3819 4908713
SGTC_104 0074-0074 590.992 µM -0.767923661043731 0.228936933242283 no 2634 0.221266269695748 3628 3943124
SGTC_2001 4023502 57.655 µM -0.768203485771555 0.228855551919402 no 2635 0.22118315146391 3809 108941 YCR052W RSC6
SGTC_340 k038-0059 454 µM -0.768565818467547 0.22875019896277 no 2636 0.221075551876073 3783 23733424
SGTC_2591 skatole 100 µM -0.769707004685804 0.2284185621764 no 2637 0.220736857018268 3826 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1677 st019204 53.9 µM -0.770082804953352 0.228309411120123 no 2638 0.220625387610764 3815 3945625
SGTC_3029 9088683 49.47 µM -0.770104021771206 0.228303249577183 no 2639 0.220619095266512 3777 25236615
SGTC_2842 9000675 19.48 µM -0.770787935089929 0.228104685447876 no 2640 0.220416319830818 3794 2989072
SGTC_2155 5570423 76 µM -0.771089449556383 0.228017176031128 no 2641 0.220326956875325 3743 797402
SGTC_2589 lobaric acid 100 µM -0.771416834988368 0.227922179395494 no 2642 0.220229949798953 3806 73157 A novel microtubule depolymerizer.
SGTC_3137 9097352 49.47 µM -0.774568983619731 0.227008668164887 no 2643 0.21929719543961 3838 44120435
SGTC_931 2812-0076 566 µM -0.77528393854269 0.226801757637905 no 2644 0.219085948993249 3813 3450959
SGTC_1109 tnp00067 928.257 nM -0.776395501542778 0.226480278712428 no 2645 0.218757749963378 3789 676295
SGTC_1606 st000094 49.2 µM -0.776602092512167 0.226420558199968 no 2646 0.218696783305637 3807 1242210
SGTC_1073 triclabendazole 3.09 µM -0.776654135800569 0.226405515131386 no 2647 0.218681426454626 3876 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_127 0180-0333 59.125 µM -0.779776482769286 0.225504036729423 no 2648 0.217761225565114 3722 771601
SGTC_1204 4049-0315 18.3 µM -0.779938478119413 0.225457321227488 no 2649 0.217713544219059 3902 588402
SGTC_90 0870-0863 4.608 µM -0.780021514116919 0.225433377798009 no 2650 0.217689105926039 3777 1738164
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.781855162249323 0.224905012376247 no 2651 0.217149849153424 3750 5355888
SGTC_1627 st003713 25.6 µM -0.782144535589458 0.224821693673279 no 2652 0.217064818036379 3867 16195070 YER133W GLC7
SGTC_167 3672-0051 66.205 µM -0.782526686570462 0.224711688505865 no 2653 0.216952554093796 3754 3237971
SGTC_1290 0986-0249 10.2 µM -0.782691002442231 0.224664398275238 no 2654 0.216904293576101 3739 53329
SGTC_3250 9135583 49.47 µM -0.783193663006399 0.224519767241642 no 2655 0.216756697808921 3838 7699353
SGTC_548 1436-0017 110 µM -0.783348274320345 0.22447529139785 no 2656 0.216711311110456 3855 9677137
SGTC_1200 1643-0193 18.4 µM -0.783436286192108 0.224449975934944 no 2657 0.216685477368995 3787 5403974
SGTC_2336 9001819 198.65 µM -0.783870703937634 0.224325045094492 no 2658 0.216557990715322 3825 2989602
SGTC_293 4049-0273 38.5 µM -0.784676615058084 0.224093383923276 no 2659 0.216321598504955 3695 1380311
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.785253619891876 0.223927605945606 no 2660 0.216152441554042 3892 4213774
SGTC_2823 7987624 58.44 µM -0.785607377354205 0.223826003143761 no 2661 0.216048770548745 3789 2239440
SGTC_1978 st071761 42 µM -0.785629623836555 0.223819614599771 no 2662 0.216042252030077 3832 5147680
SGTC_325 2810-4341 181 µM -0.786453376441675 0.223583129745127 no 2663 0.215800961654928 3801 774970
SGTC_1727 st034309 9.9045 µM -0.787660358233537 0.223236883328241 no 2664 0.215447699537732 3926 870305
SGTC_2519 cryptotanshinone 88.04 µM -0.78859137631383 0.222970011162637 no 2665 0.215175436415688 3762 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1388 3346-4487 254 µM -0.789888167811218 0.222598594690566 no 2666 0.21479654102792 3870 3345614
SGTC_2320 7373003 200 µM -0.790493083361505 0.222425460413337 no 2667 0.214619930003762 3877 5415828
SGTC_905 2-aminofluorene 215 µM -0.790918191741682 0.22230383512837 no 2668 0.214495865960532 3828 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2748 diazoxide 86.69 µM -0.794346317297993 0.221324421834064 no 2669 0.213496923434935 3820 3019 A potassium channel activatior.
SGTC_279 1273-0055 2.93 µM -0.795244680345496 0.221068168754897 no 2670 0.213235592962826 3840 2847562
SGTC_415 dibenzyl ketone 100 µM -0.798763765352478 0.220066005974826 no 2671 0.212213702376594 3855 7593
SGTC_565 1418-0001 44.5 µM -0.798923760591798 0.220020504655834 no 2672 0.212167310245882 3887 2862145
SGTC_1602 st001878 87.6 µM -0.799271335124335 0.219921675943066 no 2673 0.212066548160921 3847 595405 YLR310C CDC25
SGTC_1160 4092-0570 10.5 µM -0.800023165548202 0.219707989013233 no 2674 0.211848687781952 3820 4994975
SGTC_2087 5276107 200 µM -0.800586334647194 0.219548001951091 no 2675 0.211685582229543 3803 144405
SGTC_2626 ethyl orsellinate 100 µM -0.801353612662396 0.219330138633018 no 2676 0.211463480789359 3845 75653 A natural product.
SGTC_1166 k206-0078 225 µM -0.801972741546024 0.219154431852252 no 2677 0.211284363112944 3859 5404595
SGTC_234 nsc-17383 10.7 µM -0.803657003972958 0.218676853339387 no 2678 0.210797545966653 3839 408974
SGTC_1049 3226-0134 66 µM -0.804287747784479 0.218498158011497 no 2679 0.21061540599864 3875 5702385
SGTC_801 0866-0028 10.1 µM -0.805530888718687 0.218146211426622 no 2680 0.210256694512283 3838 6849771
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.806575831015611 0.217850629913888 no 2681 0.209955451470717 3873 4174840
SGTC_1224 0823-0416 294 µM -0.8068456538495 0.21777434300866 no 2682 0.209877706339539 3918 3598164
SGTC_2417 cerulenin 830 nM -0.806911444377599 0.217755744415216 no 2683 0.20985875241806 3877 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_421 streptovitacin 30 mM -0.806940221396675 0.217747609610066 no 2684 0.209850462219366 3937 91467 include heat shock
SGTC_2869 9037858 32.47 µM -0.808802249511515 0.217221616694623 no 2685 0.209314451045793 3788 27187042
SGTC_1138 3761-0006 1.03 µM -0.809392490971981 0.217055036320543 no 2686 0.209144710020869 3809 12061087
SGTC_3092 9117248 49.47 µM -0.809599059640108 0.216996755103256 no 2687 0.209085324368684 3911 17141857
SGTC_2518 prenyletin 46.28 µM -0.80960147605369 0.21699607339063 no 2688 0.209084629741762 3795 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2835 9006588 71.43 µM -0.811136317366377 0.216563317887004 no 2689 0.208643695905058 3932 2345538
SGTC_2859 9028643 45.46 µM -0.81182582550565 0.216369070575266 no 2690 0.2084457904935 3765 17151580
SGTC_2607 solasodine 47.35 µM -0.811900588843276 0.216348014409561 no 2691 0.208424338273012 3871 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_115 0527-0192 112.043 µM -0.812856578911695 0.216078876244734 no 2692 0.208150146024739 3883 4233931
SGTC_343 4130-2827 29.8 µM -0.816025766699959 0.215188048741061 no 2693 0.207242699417197 3915 1118244
SGTC_449 xestospongin c 11.1929 µM -0.817335715605075 0.214820458564858 no 2694 0.20686830076743 3877 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1364 1653-0028 37.6 µM -0.817656295638263 0.214730554870146 no 2695 0.206776736274524 3858 5718652
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.81826714402763 0.21455930864176 no 2696 0.206602331381532 3915 5379071
SGTC_2788 5282734 71.43 µM -0.821029511787608 0.213785893898919 no 2697 0.205814729176283 3923 743706
SGTC_2627 acetyl isogambogic acid 100 µM -0.821100653856026 0.213765996831576 no 2698 0.205794468814148 3869 6857789 A caspase activator and apoptosis inducer.
SGTC_2437 5741531 144.16 µM -0.822700839805011 0.213318740651716 no 2699 0.205339068823567 3899 2262990
SGTC_1857 st056007 79.3 µM -0.823871699807151 0.212991828138328 no 2700 0.205006231081654 3878 619834
SGTC_8 0354-0001 70 µM -0.824596883757692 0.21278949825514 no 2701 0.204800245592883 3868 4993152
SGTC_723 4182-0001 115 µM -0.825012253613345 0.21267365858139 no 2702 0.204682316973846 3854 744821 YLR208W SEC13
SGTC_1900 st060200 72.8 µM -0.827681575983196 0.211930108593389 no 2703 0.203925427917297 3851 688945
SGTC_206 4546-0025 72.014 µM -0.827785571366112 0.211901171089323 no 2704 0.203895973716686 3922 6620745 YIL048W NEO1
SGTC_1134 3477-0009 42.5 µM -0.828843125554902 0.21160702990848 no 2705 0.203596590841214 3958 3973534
SGTC_2072 5231554 129 µM -0.829886221476834 0.211317144325745 no 2706 0.203301557907471 3921 789545
SGTC_418 lividomycin a 100 µM -0.830642770219803 0.211107038365226 no 2707 0.203087732708025 3839 72394 An antibiotic.
SGTC_333 3486-0131 40.1 µM -0.832812887041399 0.210505041129872 no 2708 0.202475132768442 3948 6744690
SGTC_1887 st057648 70.8 µM -0.834829963538244 0.209946402265197 no 2709 0.201906726290031 3908 688672
SGTC_245 methotrexate 289.6 µM -0.836016540977676 0.209618181448316 no 2710 0.201572798829707 3880 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2940 9060638 45.86 µM -0.837536052901907 0.209198308147432 no 2711 0.201145660203454 3900 4027022
SGTC_873 0591-4978 488 µM -0.83791735381909 0.209093024396502 no 2712 0.201038560809098 3953 3305145
SGTC_1180 1193-0155 285 µM -0.838375037522034 0.208966691254201 no 2713 0.200910052279265 3925 2921347
SGTC_1738 st035555 74 µM -0.840050963949066 0.208504473905683 no 2714 0.200439906138575 3944 5331140
SGTC_2996 9066192 71.4286 µM -0.840237526009886 0.208453057757492 no 2715 0.200387610956824 3962 6472854
SGTC_826 1683-5028 118 µM -0.840301313242104 0.208435479833375 no 2716 0.200369732648253 3948 722377
SGTC_1409 3909-8004 61.9 µM -0.840636349051249 0.208343167968398 no 2717 0.20027584442537 3892 2119279
SGTC_2175 5807670 165.306 µM -0.84188709828258 0.207998764219592 no 2718 0.199925576332923 3875 241186
SGTC_2184 6075246 200 µM -0.8427685196377 0.207756259849774 no 2719 0.199678958681024 3926 2267320
SGTC_3020 9089140 49.47 µM -0.843398356229244 0.207583076037211 no 2720 0.199502845470899 3956 17217859
SGTC_631 k072-0230 41.5 µM -0.844743173616384 0.207213582286929 no 2721 0.199127124327552 3912 5773147
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.845043815785496 0.207131032924857 no 2722 0.199043187899145 3924 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1899 st063254 59.6 µM -0.845537398631691 0.206995548724515 no 2723 0.198905430511402 3829 3093813
SGTC_394 menadione 8.33 µM -0.846623172500756 0.206697697852994 no 2724 0.198602596819521 3891 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_232 clozapine 119 µM -0.847743631130353 0.206390598439497 no 2725 0.198290380910349 3853 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2789 5281112 71.43 µM -0.84977718071771 0.205833926832194 no 2726 0.197724489381009 3939 765948
SGTC_2364 9055074 200 µM -0.850957665901749 0.205511185387809 no 2727 0.197396434839623 3927 6470630
SGTC_607 4491-0986 66.8 µM -0.852006404821815 0.205224715209661 no 2728 0.197105268616157 3920 698981 YDR232W HEM1
SGTC_763 3453-1109 128 µM -0.85374313551289 0.20475083750557 no 2729 0.196623664010397 3944 1560353
SGTC_1288 0973-0013 65.5 µM -0.855363016226189 0.204309430198352 no 2730 0.196175105671188 3952 4315430
SGTC_3219 9131112 49.47 µM -0.855418816409248 0.204294235100783 no 2731 0.196159665203931 3862 17612988 YMR079W SEC14
SGTC_1443 4112-3303 14 µM -0.856557183979148 0.203984390083834 no 2732 0.195844828443687 3928 704433
SGTC_1985 st071382 65.5 µM -0.856730270631487 0.203937303266027 no 2733 0.195796984976657 3912 6123237
SGTC_1451 4152-0210 104 µM -0.85704156794372 0.203852633662403 no 2734 0.195710956086682 3877 659563
SGTC_1748 st037455 53.6035 µM -0.857712580310288 0.203670196606624 no 2735 0.195525595822555 3948 580690
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.858316920687376 0.203505969904045 no 2736 0.195358744291035 3901 390807
SGTC_1481 3346-2004 36 µM -0.858980441676491 0.203325752142767 no 2737 0.195175653314227 3943 2770522
SGTC_251 melphalan 456.522 µM -0.859863929773164 0.203085937386976 no 2738 0.194932026883522 3962 460612 A DNA alkylator.
SGTC_2311 7694451 200 µM -0.862414150675095 0.202394651199318 no 2739 0.194229828166906 3885 2163142
SGTC_1880 MG-132 525 µM -0.864242414978002 0.201899932264312 no 2740 0.193727368236252 3857 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2197 6588183 93.1375 µM -0.864454858006319 0.201842493256764 no 2741 0.193669034182571 3855 884136
SGTC_699 0375-0592 111 µM -0.864777589725435 0.20175525381173 no 2742 0.193580436806162 3971 762578
SGTC_2485 5633444 17.78 µM -0.866204191642693 0.201369891543333 no 2743 0.19318909756105 3952 5724239
SGTC_15 0266-0086 27.098 µM -0.866700624186139 0.201235895748574 no 2744 0.193053031680161 4000 1712902 YIL048W NEO1
SGTC_136 0097-0015 404.482 µM -0.868347383696977 0.200791789605426 no 2745 0.192602094881734 3926 4861337
SGTC_66 0109-0187 42.4 µM -0.870164910150779 0.200302313696876 no 2746 0.192105144555927 3872 759417
SGTC_697 0508-1955 564 µM -0.874011387557256 0.199268790323877 no 2747 0.191056026127439 3924 6243113
SGTC_1018 4259-0013 28.1 µM -0.87407878479628 0.199250709801921 no 2748 0.191037675053217 4013 6801262
SGTC_1573 oleylamine 1.06 µM -0.874377588852737 0.199170562138717 no 2749 0.190956329023007 3939 5356789 An amine of the fatty acid oleic acid.
SGTC_464 bw-b 70c 158 µM -0.876263730702517 0.198665094102144 no 2750 0.190443338702924 3994 5353454
SGTC_1812 st052057 4.327 µM -0.876692414507383 0.198550318912398 no 2751 0.190326863994459 3955 3645418
SGTC_1248 0469-0687 58.6 µM -0.878283035289212 0.198124798041252 no 2752 0.189895069945212 3950 4017482
SGTC_1119 parthenolide 318.541 nM -0.878773717962659 0.197993642437646 no 2753 0.189761989600309 4063 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2657 nystatin 74.44 µM -0.880589800610289 0.197508674258793 no 2754 0.1892699405015 3994 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1267 0828-0272 9.49 µM -0.881329699143404 0.197311297241615 no 2755 0.189069697931705 4032 745334
SGTC_1772 st048439 82.2 µM -0.881358890312657 0.19730351258601 no 2756 0.189061800450889 3997 2927068 YDL195W SEC31
SGTC_1066 ketoconazole 628 nM -0.881497220682111 0.197266625384455 no 2757 0.189024378832702 4005 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_753 1322-0200 289 µM -0.882262625034259 0.197062597933763 no 2758 0.188817401430069 4021 5403907
SGTC_2154 5570129 200 µM -0.882411590610591 0.197022904274792 no 2759 0.188777135031909 3968 673366
SGTC_2979 9012552 45.46 µM -0.883536581933895 0.196723293185439 no 2760 0.188473213229727 3977 17100905
SGTC_1041 0206-0046 107 µM -0.883558069555764 0.196717573224037 no 2761 0.188467411183978 3970 50494
SGTC_1937 st074714 47.2 µM -0.883565743651671 0.196715530419668 no 2762 0.188465339066264 3900 17250970
SGTC_2984 9022109 38.96 µM -0.884716079475411 0.196409462342895 no 2763 0.188154890550035 3982 6459207
SGTC_2558 carylophyllene oxide 100 µM -0.885211194017337 0.1962778168765 no 2764 0.188021368013174 4049 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1274 0865-0114 173 µM -0.887840844557788 0.195579518955362 no 2765 0.18731318436108 3974 870624
SGTC_1653 st012112 65 µM -0.888596536536059 0.195379125988926 no 2766 0.187109976561717 3936 720429
SGTC_71 0417-1750 47.813 µM -0.89001002485981 0.195004634828792 no 2767 0.186730251600864 3941 6811472
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.890846749454912 0.194783157859587 no 2768 0.186505695609088 3949 16486 A toxic proline analog.
SGTC_575 k072-0246 11.9 µM -0.893416328152595 0.194103959786499 no 2769 0.185817130897513 3984 6796779
SGTC_1209 2323-2347 50.3 µM -0.894461668982401 0.193828065790853 no 2770 0.185537464835648 3949 5412760
SGTC_307 1501-1223 22.3 µM -0.894782802002205 0.193743358035031 no 2771 0.185451602744053 3976 2830329
SGTC_3143 9086658 49.47 µM -0.897909371449632 0.192919818547711 no 2772 0.184616934033401 4047 25236626
SGTC_3193 9111931 49.47 µM -0.899697934565509 0.192449673247131 no 2773 0.1841405114285 3985 17087244
SGTC_1024 4507-0395 26 µM -0.900698122282855 0.192187067555162 no 2774 0.183874423664979 4053 4201836
SGTC_1277 0873-0036 22 µM -0.901601663492268 0.191950025583694 no 2775 0.18363425351857 4029 5965735
SGTC_2711 st079103 59.1 µM -0.90244080955403 0.191730037879336 no 2776 0.183411375395804 3937 54693780
SGTC_724 3910-0327 137 µM -0.902500738867828 0.191714332921279 no 2777 0.183395464558286 4020 2885483
SGTC_1171 0368-0077 21.4 µM -0.902937794037109 0.191599822927005 no 2778 0.183279455316218 3919 3239779
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.902938451414516 0.191599650723369 no 2779 0.183279280860467 3968 688669
SGTC_2755 lomerizine 42.69 µM -0.903838201468141 0.191364045106547 no 2780 0.183040600982117 3943 3949 A calcium channel blocker.
SGTC_3332 9141069 11.198 µM -0.905719328156329 0.190872033387607 no 2781 0.182542214765431 3904 17332883
SGTC_2661 dactinomycin 12.96 µM -0.906202510579847 0.190745781628678 no 2782 0.182414337218409 3956 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_465 cgp-37157 41 µM -0.908075963038333 0.190256748016187 no 2783 0.181919044526031 3927 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1992 st073643 23.3 µM -0.908235900088514 0.190215034823154 no 2784 0.181876800279404 3928 3161292
SGTC_2837 9008476 45.46 µM -0.911353054311068 0.189403171917779 no 2785 0.181054690318827 3999 2992805
SGTC_1103 duloxetine 36.1 µM -0.911661550626862 0.189322940184472 no 2786 0.180973455124101 4074 60835 A selective serotonin reuptake inhibitor.
SGTC_533 1222-0222 6.71 µM -0.912307730656923 0.189154953665757 no 2787 0.180803372963025 4049 3982874
SGTC_1004 4084-0029 199 µM -0.913448961500586 0.188858493769198 no 2788 0.180503232472511 4009 716894 YLR208W SEC13
SGTC_1972 st070201 17.4 µM -0.913834202571546 0.188758483570421 no 2789 0.18040198575435 3964 2829099
SGTC_1843 st055809 45.5 µM -0.91872874820946 0.187490682389717 no 2790 0.179118734518415 4059 16413835
SGTC_371 0195-0006 7.36 µM -0.919293409797346 0.18734476123699 no 2791 0.178971061960632 3842 3928593
SGTC_834 0312-0008 75.7 µM -0.920094559727169 0.187137846730707 no 2792 0.178761673527717 3988 6385573 YIL048W NEO1
SGTC_1281 0884-0031 11.8 µM -0.920096542426424 0.187137334830615 no 2793 0.178761155521103 4011 1548255
SGTC_1449 4112-4002 201 µM -0.921084713361113 0.186882313255865 no 2794 0.17850310029876 4060 2059539
SGTC_2956 9076196 2.52 µM -0.922263427506505 0.186578398775296 no 2795 0.178195592844629 4009 16423868
SGTC_1164 k060-0068 93.7 µM -0.922536341090086 0.186508075592132 no 2796 0.178124441736819 3993 5963676
SGTC_1663 st014140 55.4 µM -0.923872397181938 0.186164043418663 no 2797 0.177776377991102 4072 4207120
SGTC_91 0417-1751 58.384 µM -0.924922923915008 0.185893810966732 no 2798 0.177503000686102 4111 6795624
SGTC_1539 benzyladenosine 56 µM -0.926047752871613 0.185604735189647 no 2799 0.177210582135637 3987 92208 A nucleotide analog.
SGTC_1156 4092-0367 4.88 µM -0.929855042474864 0.184628351135377 no 2800 0.176223071458096 4012 1357585
SGTC_2592 piperlongumine 83.33 µM -0.930950925672529 0.184347903579545 no 2801 0.175939474946529 4030 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1613 st002381 52.1 µM -0.931610813354457 0.184179159590036 no 2802 0.175768846378531 4000 551167
SGTC_1127 asiatic acid 681.4 nM -0.932358208640136 0.183988154632145 no 2803 0.175575717426936 3973 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_329 k048-0121 21.3 µM -0.934915714278157 0.183335489980172 no 2804 0.174915869004117 4027 6832902
SGTC_2380 9035439 200 µM -0.93495544446768 0.183325362403705 no 2805 0.174905630858224 4129 6462575
SGTC_1712 st032288 53.4 µM -0.934959424420247 0.183324347897842 no 2806 0.174904605277854 3934 2883011
SGTC_2319 6033012 152.6 µM -0.935566480980861 0.183169647736799 no 2807 0.174748219633353 3961 847246
SGTC_3301 9125354 19.7965 µM -0.936071184422208 0.183041092894445 no 2808 0.174618269078141 3988 41905162
SGTC_2939 9044578 71.43 µM -0.938388469591337 0.182451571630746 no 2809 0.174022404657518 3964 2653634
SGTC_2295 7971645 200 µM -0.939427152752205 0.182187714281706 no 2810 0.173755738769011 4076 2978226 YKL099C UTP11
SGTC_2178 5812956 200 µM -0.940065144951975 0.182025763015126 no 2811 0.173592073040029 3979 5403383
SGTC_2960 9079389 5.97 µM -0.940994565589329 0.181789995169317 no 2812 0.173353822054336 4043 16457355
SGTC_2884 9058502 51.95 µM -0.941229668455328 0.181730386478516 no 2813 0.173293587956323 4069 6471554
SGTC_1509 1326-1131 80 µM -0.942335253883174 0.181450237001728 no 2814 0.173010512177478 3936 768313
SGTC_1716 st033144 30.6155 µM -0.944010093765862 0.181026356776864 no 2815 0.172582245125241 4023 674617
SGTC_459 nigericin 15.3 µM -0.946718800657018 0.180342132592303 no 2816 0.171891043821742 4089 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2556 citropten 84.59 µM -0.947059092659788 0.180256289109012 no 2817 0.171804334082655 4058 2775 A potential DNA crosslinker.
SGTC_1151 3909-8316 15.3 µM -0.947647083974166 0.180108020410675 no 2818 0.17165457397903 4075 800431
SGTC_477 mead ethanolamide 10 µM -0.948270492788397 0.179950904431064 no 2819 0.171495884228881 3926 16061185
SGTC_5 0352-0601 109.883 µM -0.950585587487101 0.179368191217502 no 2820 0.170907393886892 3965 762456
SGTC_888 0916-0002 6.97 µM -0.955298695858111 0.17818556504853 no 2821 0.169713333414258 4088 2802138 YIL048W NEO1
SGTC_3321 9137793 26.8275 µM -0.955988369559713 0.178012923347801 no 2822 0.169539055231547 4000 4904192
SGTC_1708 st033234 31.827 µM -0.95967488900728 0.177091889553375 no 2823 0.168609432575355 4135 674664
SGTC_1774 st048371 48.465 µM -0.960315571224 0.176932130191456 no 2824 0.168448207783033 4022 4242727
SGTC_1446 4239-0190 62 µM -0.964711406398369 0.175838450165734 no 2825 0.16734469024369 4064 1340085
SGTC_39 0986-0283 58.349 µM -0.965996554624869 0.175519517028081 no 2826 0.167022952533074 4135 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_896 0964-0007 44.5 µM -0.967972337529243 0.175029905831782 no 2827 0.16652909256932 3995 6756758
SGTC_1670 st016595 4.04 µM -0.968205313426781 0.174972230131553 no 2828 0.16647092089831 4054 597879
SGTC_1625 st003711 30.1 µM -0.968227021286832 0.174966856730521 no 2829 0.166465501338465 4151 24207034 YER133W GLC7
SGTC_2872 9044037 25.97 µM -0.968834750310058 0.174816466541657 no 2830 0.166313822629849 4049 6465195
SGTC_1434 4073-0095 163 µM -0.969085359739006 0.174754473987268 no 2831 0.166251300827108 3983 24133745
SGTC_1293 1000-1278 195 µM -0.969928055578683 0.174546121045177 no 2832 0.166041177228414 4109 678847
SGTC_2486 5283202 22.39 µM -0.971107335665283 0.174254814066447 no 2833 0.165747415614958 4107 1377751
SGTC_903 1134-0042 114 µM -0.974568543329794 0.173401608279075 no 2834 0.164887161821037 4078 701009
SGTC_676 falcarinol 140 µM -0.974737087082583 0.173360129375502 no 2835 0.164845345664361 4050 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2897 9048598 12.99 µM -0.976859897372862 0.1728382430426 no 2836 0.164319258869932 4045 6467404
SGTC_937 3122-0005 46.7 µM -0.977088383343567 0.172782130220463 no 2837 0.164262699151558 4099 759535
SGTC_561 1550-0330 72.9 µM -0.9775507376335 0.172668618275343 no 2838 0.164148285985155 4001 6812934
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.979098628745482 0.172288943835423 no 2839 0.163765624564042 4056 5106787 A p450 inhibitor.
SGTC_3240 9133527 49.47 µM -0.980262278068984 0.172003869138468 no 2840 0.163478334930335 3992 17617455
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.980791003421093 0.171874439788333 no 2841 0.163347907845513 4017 16623 A steroid.
SGTC_774 k060-0086 136 µM -0.980947433040176 0.171836158516625 no 2842 0.163309332419358 4024 5911235
SGTC_954 1189-0853 2.85 µM -0.981645873707731 0.171665303376958 no 2843 0.163137169688785 4010 2828194
SGTC_2741 miltefosine 3.04 µM -0.985904205508918 0.170625963524097 no 2844 0.162090061492569 4047 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2126 5251174 33.877 µM -0.986033646589773 0.170594433789371 no 2845 0.162058301102797 4103 790722
SGTC_2460 5552655 174.22 µM -0.987265484531928 0.170294564852738 no 2846 0.161756253274255 4101 5401989
SGTC_2398 5228213 48.84 µM -0.988988745890357 0.169875634643212 no 2847 0.161334323968121 4100 80771 YMR134W ERG29
SGTC_130 0136-0219 337.655 µM -0.992845423415894 0.168940460788811 no 2848 0.160392644952853 3919 234244
SGTC_1351 1496-0003 46.5 µM -0.993160143427528 0.168864293155713 no 2849 0.160315959073094 4100 3891978
SGTC_885 0865-0106 16.8 µM -0.99380615849627 0.168708015581261 no 2850 0.160158623660781 4020 2793380
SGTC_1897 st060201 15 µM -0.994537856831846 0.168531122656692 no 2851 0.159980542252564 4132 611878
SGTC_1023 4482-3888 16 µM -0.996269670890525 0.16811292042992 no 2852 0.159559567919162 4113 3303168
SGTC_1866 st057638 64 µM -0.998268920432617 0.16763096842487 no 2853 0.159074487057545 4063 688802
SGTC_3088 9117578 49.47 µM -1.00000267317574 0.167213740015651 no 2854 0.158654607102052 4123 678341
SGTC_2806 7952793 58.44 µM -1.00088101882841 0.167002621420375 no 2855 0.158442167075352 4166 2972490
SGTC_305 1682-2595 20.8 µM -1.00286000733179 0.166527583278639 no 2856 0.157964205500849 4103 226033
SGTC_324 1315-0088 19.6 µM -1.00299839698217 0.166494396767405 no 2857 0.157930817344577 4057 6787421
SGTC_776 4476-4378 112 µM -1.00837563723358 0.165208214868734 no 2858 0.156637082103003 4158 2892008
SGTC_2950 9072895 21.46 µM -1.01368306990358 0.163945053501911 no 2859 0.155367002542427 4071 17332245
SGTC_1059 3448-6867 171 µM -1.01446458668935 0.163759584337634 no 2860 0.155180559604122 4025 3934407
SGTC_1478 0453-0656 35.7 µM -1.014623994832 0.16372177040813 no 2861 0.155142548464829 4090 5258496
SGTC_2594 a-mangostin 100 µM -1.01522499875065 0.163579254513354 no 2862 0.154999293350814 4148 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1865 st057639 52.2 µM -1.01573741024392 0.163457810153036 no 2863 0.154877224110312 4080 688818
SGTC_199 4063-0024 41.6 µM -1.01625391653738 0.163335454581035 no 2864 0.154754243666855 4114 306215
SGTC_3223 9129970 49.47 µM -1.01855144417307 0.162791912687193 no 2865 0.154207983012768 4131 17248386
SGTC_372 0155-0182 15.9 µM -1.01941498889415 0.162587922488154 no 2866 0.154002996587872 4018 771486
SGTC_3057 9095946 49.47 µM -1.01979670406469 0.162497805137185 no 2867 0.153912443332972 4139 24540043
SGTC_2418 pentamidine 31.67 µM -1.02135184665393 0.162130994817911 no 2868 0.15354388534447 4069 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2082 5219693 150 µM -1.02345510896999 0.161635758347016 no 2869 0.153046357292158 4106 2834649
SGTC_76 0433-0009 400.328 µM -1.02349817427246 0.161625628455713 no 2870 0.15303618134438 4195 2841569
SGTC_2969 9091408 28.7 µM -1.02439507066055 0.1614147530708 no 2871 0.152824354647758 4060 4286311
SGTC_2968 9090663 33.37 µM -1.02448417377983 0.161393813235044 no 2872 0.152803321123887 4074 25236811
SGTC_442 cape 100 µM -1.02592263443687 0.161056010414542 no 2873 0.152464026341556 4103 5281787
SGTC_2528 xanthyletin 44.79 µM -1.02841355639972 0.160472143526353 no 2874 0.151877667171478 4156 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_336 4111-0029 111 µM -1.02957785477097 0.160199709283121 no 2875 0.151604107625323 4117 3131175
SGTC_792 4534-1957 155 µM -1.02966741640953 0.160178765280454 no 2876 0.151583078105254 4049 1717904
SGTC_2376 9072922 81.32 µM -1.0327557921512 0.15945764329829 no 2877 0.150859098380628 4149 17087968
SGTC_1919 st067113 52.3 µM -1.03533232189577 0.158857663745783 no 2878 0.150256870060763 4162 1268243
SGTC_551 k048-0028 34.9 µM -1.03559777571903 0.15879593344028 no 2879 0.15019491505332 4126 6836383
SGTC_2656 pseudo-anisatin 100 µM -1.03568915445208 0.158774687292118 no 2880 0.150173591856239 4156 6708809 A neurotoxin.
SGTC_1196 1588-0294 184 µM -1.03782359624693 0.158278945863059 no 2881 0.149676094607125 4143 6144269
SGTC_1307 1187-1599 12.2 µM -1.03857857886849 0.158103838443248 no 2882 0.149500386268991 4107 1538471
SGTC_2634 4'-methoxyflavone 100 µM -1.04002993853547 0.15776757364751 no 2883 0.149162995807136 4143 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2680 butyl paraben 22.24 µM -1.04084749099524 0.157578362311704 no 2884 0.148973167468828 4202 7184 An antifungal and steroid mimetic.
SGTC_179 1273-0063 6.77 µM -1.04150622410212 0.157426016056167 no 2885 0.148820333020379 4108 3108139
SGTC_1800 st050079 29.0735 µM -1.04387226112381 0.156879617468844 no 2886 0.148272246723505 3997 3645560
SGTC_1498 4478-3555 97.6 µM -1.04424403606063 0.156793875538034 no 2887 0.148186248948737 4113 3437919
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.04442702077623 0.156751685357167 no 2888 0.148143933774657 4012 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2034 5197015 53.07 µM -1.0454155489419 0.156523892902925 no 2889 0.147915476694356 4145 780676
SGTC_3153 9100258 49.47 µM -1.04630522861952 0.156319065143205 no 2890 0.147710066078777 4079 25236848
SGTC_3158 9100007 49.47 µM -1.0470315681858 0.156151973556605 no 2891 0.147542509391013 4163 19297233
SGTC_1312 1218-2183 165 µM -1.04836022299852 0.15584662633343 no 2892 0.147236336354927 4184 6744073
SGTC_2916 7875993 68.79 µM -1.04870657570863 0.155767093382891 no 2893 0.147156593434014 3985 1299250
SGTC_1770 st043884 66.3 µM -1.05218061869697 0.154970829861721 no 2894 0.146358344924512 4142 670149
SGTC_3283 9109332 35.8195 µM -1.05263670500926 0.154866493164197 no 2895 0.146253763960685 3982 17027281
SGTC_252 miconazole 1.30953 nM -1.05630499554569 0.154029003535316 no 2896 0.145414447199652 4051 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1795 st049545 62.3 µM -1.06187320601911 0.152763489085651 no 2897 0.144146625177431 4110 5291882
SGTC_3003 9075612 71.4286 µM -1.06203451981037 0.152726929590521 no 2898 0.144110007176595 4182 6501993
SGTC_349 k015-0014 24 µM -1.06539671041441 0.151966257573673 no 2899 0.143348222392808 4141 2196908
SGTC_3120 9124077 49.47 µM -1.0669595588617 0.151613532332869 no 2900 0.142995049069842 4280 18774327 YGL155W CDC43
SGTC_1115 galangin 695.678 nM -1.06852405532769 0.151260980632997 no 2901 0.142642092682039 4228 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2998 9066762 71.4286 µM -1.07048359529376 0.150820177610985 no 2902 0.142200844588732 4234 4945196
SGTC_3351 9150312 21.596 µM -1.07112289225058 0.150676551489167 no 2903 0.142057088110671 4087 4904905
SGTC_161 4065-0411 162.148 µM -1.07204222565037 0.150470171362973 no 2904 0.141850533316625 4167 1906281 YLR208W SEC13
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.07206857082216 0.150464259941704 no 2905 0.141844617112177 4150 364106
SGTC_2069 5228469 200 µM -1.07266331991506 0.150330849242425 no 2906 0.141711101724778 4175 2835210
SGTC_2444 5485484 36.41 µM -1.07284648029614 0.150289779638063 no 2907 0.14167000115036 4248 6790631
SGTC_18 0111-0177 500 nM -1.07347338325237 0.150149267318247 no 2908 0.141529387353418 4235 721752
SGTC_3051 9093778 49.47 µM -1.07578108807921 0.149632779348707 no 2909 0.141012586098111 4220 17217378
SGTC_1106 tegaserod maleate 11.7 µM -1.07598597106359 0.149586981802972 no 2910 0.140966765313953 4184 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2904 7225135 42.03 µM -1.07752441933562 0.149243390904825 no 2911 0.140623023725346 4279 4446116
SGTC_2645 abamectin 100 µM -1.07810556494214 0.149113737404892 no 2912 0.14049332422622 4127 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1662 st014054 52 µM -1.07879542482592 0.148959927449638 no 2913 0.140339467434627 4213 2838777
SGTC_702 1488-0190 94 µM -1.08235732299312 0.148167459837219 no 2914 0.13954689192597 4205 949357
SGTC_450 aminopyrene 156 nM -1.08584557393386 0.147394116498516 no 2915 0.138773659791493 4108 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_543 3844-1095 191 µM -1.08747061286909 0.147034771429849 no 2916 0.138414439568356 4178 4230703
SGTC_1640 st009078 66.4 µM -1.0891521504566 0.14666355176156 no 2917 0.13804339783642 4158 690618
SGTC_2278 7948257 134.34 µM -1.08951099672177 0.146584413625519 no 2918 0.137964304083455 4176 1247028
SGTC_2348 9022543 33.42 µM -1.08988182158878 0.146502663904645 no 2919 0.137882602594172 4221 3162678 YDL140C RPO21
SGTC_1148 3909-7663 27.7 µM -1.09027178207674 0.146416728683535 no 2920 0.137796720687693 4223 4084526
SGTC_2083 5306046 65.942 µM -1.09127721755659 0.14619531796068 no 2921 0.137575459685519 4193 539837
SGTC_1664 st014217 9.02 µM -1.09220060397925 0.145992173764026 no 2922 0.137372468540945 4241 3982782
SGTC_802 4112-3352 742 µM -1.0922975178028 0.145970863811294 no 2923 0.137351175514377 4247 704594
SGTC_2062 5245942 200 µM -1.09549924261487 0.145268025698732 no 2924 0.13664898857428 4237 1376160
SGTC_2362 9071156 126 µM -1.09653732605771 0.145040636683901 no 2925 0.136421848956519 4208 653133
SGTC_3070 9117005 49.47 µM -1.09816832400589 0.144683855709555 no 2926 0.13606549759213 4277 8779016
SGTC_3211 9128781 49.47 µM -1.09820436222897 0.144675979025343 no 2927 0.136057630921147 4189 17194361
SGTC_3227 9130768 49.47 µM -1.09873754480343 0.144559477872189 no 2928 0.135941280540875 4242 17720899
SGTC_1101 ebselen 5.29 µM -1.09908913905593 0.144482688616611 no 2929 0.13586459340147 4231 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2145 5634607 200 µM -1.10377189922264 0.143462580316368 no 2930 0.134846048763809 4160 308662
SGTC_1362 1611-0397 101 µM -1.10731890307746 0.142693133059031 no 2931 0.134078037186353 4164 27816
SGTC_583 1488-1091 88.9 µM -1.10795338718378 0.1425557899251 no 2932 0.133940973621768 4313 4303273
SGTC_2275 7947463 200 µM -1.1083663208235 0.142466452588894 no 2933 0.133851821937307 4173 1225414
SGTC_2433 5607874 27.82 µM -1.10971736126379 0.142174422468162 no 2934 0.133560419618034 4167 2252428
SGTC_1233 0325-0408 14.2 µM -1.10999278890566 0.142114937974013 no 2935 0.133501066938097 4228 12874
SGTC_732 3970-1727 52.7 µM -1.11173084121744 0.141739956940724 no 2936 0.133126947569306 4277 1275699
SGTC_3028 9087778 49.47 µM -1.11284986388843 0.14149888515223 no 2937 0.132886457803907 4187 17217395
SGTC_1761 st044296 37 µM -1.11599950889318 0.140821847256733 no 2938 0.132211172411861 4193 1826700
SGTC_2438 5259590 200 µM -1.11675267044309 0.140660276155915 no 2939 0.132050045321885 4221 1201127
SGTC_1993 st073995 70.8 µM -1.12111149079244 0.139727676800515 no 2940 0.13112020404326 4199 3098394
SGTC_622 1348-1566 26.3 µM -1.12135006519296 0.13967675380423 no 2941 0.131069441261061 4217 7340407
SGTC_280 3448-3607 3.04 µM -1.12214672338246 0.139506800910855 no 2942 0.130900030304462 4176 626179
SGTC_1313 1220-0047 237 µM -1.12401743742297 0.13910827034373 no 2943 0.130502814269222 4181 3528706
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.12537161343151 0.13882026524012 no 2944 0.130215797387365 4345 16725076
SGTC_2203 7227154 166.4 µM -1.12657078953121 0.138565564638041 no 2945 0.129961997547089 4221 896304
SGTC_1883 5-benzylidenerhodanine 20 µM -1.12717269597806 0.138437842007453 no 2946 0.129834736109032 4201 1273210
SGTC_977 1348-1378 135 µM -1.12842177842417 0.138173046765952 no 2947 0.129570917257815 4206 X977
SGTC_55 0767-0285 6.563 µM -1.12951394578085 0.137941799402122 no 2948 0.129340544964885 4139 3116166
SGTC_2911 7942208 15.64 µM -1.13038024536111 0.137758563444998 no 2949 0.129158017246979 4258 1243384
SGTC_2032 5185112 25.99 µM -1.13230782219445 0.137351446837398 no 2950 0.128752521325682 4111 5718189
SGTC_1286 0929-0070 131 µM -1.13283259205543 0.137240754502672 no 2951 0.128642280903222 4285 1420408
SGTC_1479 0549-0158 134 µM -1.13455681499882 0.136877484594983 no 2952 0.128280527988737 4280 5440202
SGTC_577 r071-0003 38.6 µM -1.13530212718479 0.136720661257383 no 2953 0.128124375629334 4222 4568517 YMR134W ERG29
SGTC_2773 thioridazine 9.09 µM -1.13551908753083 0.136675033083657 no 2954 0.128078944504309 4222 5452 An antipsychotic.
SGTC_730 1436-0052 41.2 µM -1.13666793486314 0.136433596550046 no 2955 0.127838564349471 4258 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1458 k015-0034 6.33 µM -1.13890644895453 0.135963999063052 no 2956 0.127371087768201 4259 3598957
SGTC_2628 lathosterol 100 µM -1.1404541236349 0.135639974246291 no 2957 0.127048577557635 4301 6710616
SGTC_2283 7944793 200 µM -1.14117174601593 0.13548991078766 no 2958 0.12689922974538 4248 2970533
SGTC_2455 5377712 9.75 µM -1.14262954448347 0.135185418013204 no 2959 0.126596216769392 4222 2243908
SGTC_2181 6316240 54.2555 µM -1.15002950491922 0.133647013855329 no 2960 0.12506585960726 4254 12779990
SGTC_2540 epiandrosterone 100 µM -1.15245113306339 0.133146197324098 no 2961 0.124567869710078 4277 441302 A steroid.
SGTC_741 4582-0002 126 µM -1.15383267817826 0.132861059527729 no 2962 0.124284386990897 4251 2912688
SGTC_203 k066-0004 30.888 µM -1.15505943902866 0.13260822041654 no 2963 0.12403304333334 4327 6795412
SGTC_2652 actinonin 100 µM -1.1551569122068 0.132588145124957 no 2964 0.124013087903825 4271 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1108 betulinic acid 729.144 nM -1.15803141560677 0.131997061950465 no 2965 0.12342560816346 4240 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.15933632643814 0.131729334224149 no 2966 0.123159560009166 4308 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1709 st033179 39.1045 µM -1.15986764492101 0.131620431363168 no 2967 0.123051348826906 4239 573381
SGTC_1342 1486-1464 234 µM -1.1602185385224 0.131548543761739 no 2968 0.122979920499803 4272 3253938
SGTC_2165 5727197 32.143 µM -1.16282848593523 0.131014694070648 no 2969 0.122449548586891 4371 1361712
SGTC_1529 apigenin 74 µM -1.16659012468263 0.130247908975974 no 2970 0.121687966644895 4282 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_478 N-arachidonylglycine 10 µM -1.16822561618402 0.129915495266334 no 2971 0.121357885146141 4236 5283389
SGTC_3299 9121982 43.1275 µM -1.16904170956051 0.129749844099601 no 2972 0.121193413541633 4294 17594604 YPL160W CDC60
SGTC_621 3584-0052 32.1 µM -1.16951492866782 0.12965385680289 no 2973 0.121098115040119 4277 2273927
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.17077916337632 0.129397661941379 no 2974 0.120843777653014 4276 7104
SGTC_923 1900-2434 73.3 µM -1.17210987573281 0.129128374691102 no 2975 0.120576472728197 4244 5910570
SGTC_1369 1866-0067 208 µM -1.17308667357728 0.128930954162229 no 2976 0.120380525017612 4287 3531355
SGTC_3172 9105863 49.47 µM -1.17528648578191 0.128487117158647 no 2977 0.119940059679192 4333 2348785
SGTC_3337 9144342 33.5465 µM -1.17599280569951 0.128344834310916 no 2978 0.119798875473324 4250 17682949
SGTC_2172 5754775 163.918 µM -1.17656620021036 0.128229408766242 no 2979 0.119684347543947 4245 2263357
SGTC_743 1275-0778 158 µM -1.1771826993739 0.128105386604087 no 2980 0.119561296199424 4235 2849257 YMR203W TOM40
SGTC_1816 st051957 91.6 µM -1.18240036383885 0.127059076674968 no 2981 0.118523439455496 4255 674121
SGTC_2443 5493264 126.67 µM -1.18391342786676 0.126756774050888 no 2982 0.118223667086617 4315 5340055
SGTC_2285 7945142 200 µM -1.18427974953565 0.126683660178201 no 2983 0.118151171119995 4312 2970608
SGTC_793 0488-0545 106 µM -1.18451968955451 0.12663578664722 no 2984 0.118103703438466 4299 292548
SGTC_1437 4092-1038 11.6 µM -1.18820999277261 0.125901073436644 no 2985 0.117375343871876 4316 3977136
SGTC_2719 novobiocin 32.65 µM -1.18881932557196 0.125780046121965 no 2986 0.117255385772176 4312 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2912 7964298 10.93 µM -1.18976680576765 0.125592016309389 no 2987 0.117069029828738 4280 2975850
SGTC_3185 9108267 49.47 µM -1.19241408539512 0.125067696941903 no 2988 0.116549460008558 4280 4910486
SGTC_13 0199-0087 65 µM -1.19264263362485 0.125022502549394 no 2989 0.116504680672572 4367 4589825
SGTC_46 0329-0187a 2.197 µM -1.19405608093141 0.124743253080149 no 2990 0.116228015764543 4323 46494817
SGTC_1405 3909-7894 12 µM -1.19609243885461 0.124341704346754 no 2991 0.115830243971341 4262 7104060
SGTC_2301 7769476 200 µM -1.19766853384154 0.124031535924437 no 2992 0.115523041943667 4290 977820
SGTC_2290 7904846 200 µM -1.19849425314269 0.123869254369106 no 2993 0.11536232947602 4319 2962154
SGTC_443 clozapine 122 µM -1.20185960685948 0.123209386879087 no 2994 0.114708963323357 4252 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1353 1498-1206 8.11 µM -1.20642641323816 0.122317887924041 no 2995 0.113826558371232 4317 6756808
SGTC_2521 angolensin 13.4 µM -1.21129500594977 0.121372473518363 no 2996 0.112891181032952 4346 821428 A flavenoid.
SGTC_3023 9089636 49.47 µM -1.21193128863516 0.121249296732733 no 2997 0.112769341947332 4365 17249241
SGTC_820 1582-0060 59.9 µM -1.21360842358393 0.120925044630201 no 2998 0.112448644422399 4311 3848840
SGTC_1526 st051518 75 µM -1.21405975394626 0.120837890101643 no 2999 0.112362453535182 4281 673993
SGTC_2771 fluoxetine 41.05 µM -1.21439848952505 0.120772507330819 no 3000 0.112297795971771 4322 3386 A selective serotonin reuptake inhibitor.
SGTC_2219 9098279 200 µM -1.21843380726912 0.119995524792455 no 3001 0.111529582237863 4234 902349
SGTC_964 1287-0107 19.4 µM -1.22158153952602 0.119391893893996 no 3002 0.11093295659014 4319 51516812 YPR165W RHO1
SGTC_1001 4048-4355 44.4 µM -1.2218793501124 0.119334894823328 no 3003 0.110876627759312 4286 21824233
SGTC_2262 9014885 67.46 µM -1.22705523201981 0.118347329578 no 3004 0.109900916237104 4307 6457424
SGTC_3117 9124945 49.47 µM -1.22890534695335 0.117995730771688 no 3005 0.109553648247594 4206 17592065
SGTC_54 0159-0055 9 µM -1.22980661919938 0.117824719464093 no 3006 0.109384764467035 4312 3319099
SGTC_1700 st030840 7.9285 µM -1.23077058180078 0.11764200719666 no 3007 0.109204340588175 4350 5499307
SGTC_1829 berberine 14.4 µM -1.23287875125216 0.117243117788357 no 3008 0.108810502118651 4263 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1764 st044502 93.5 µM -1.2341698826892 0.116999294732264 no 3009 0.108569803747251 4347 8407
SGTC_2780 5215298 71.43 µM -1.2348581493659 0.116869466291205 no 3010 0.108441650675361 4336 2834131
SGTC_134 0269-0018 6.916 µM -1.23509364885623 0.116825067239776 no 3011 0.108397826418156 4278 4378915
SGTC_2298 7976326 193.81 µM -1.23709705897112 0.116447844971484 no 3012 0.108025525756486 4229 2235818
SGTC_1879 gemcitabine 100 µM -1.23804553528636 0.116269557951951 no 3013 0.107849588585672 4290 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2508 celastrol 40.54 µM -1.23855077774127 0.11617466560859 no 3014 0.107755953165451 4251 122724 Celastrol is a natural product and antioxidant.
SGTC_277 nystatin 15.5 µM -1.242959323704 0.11534900413484 no 3015 0.106941411520566 4337 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1629 st005085 44.9 µM -1.24482453989738 0.115000932703647 no 3016 0.10659812678904 4265 24207091
SGTC_1133 3473-0247 50 µM -1.24566065502382 0.114845146428732 no 3017 0.106444501993924 4300 711311
SGTC_2541 muurolladie-3-one 83.07 µM -1.24661020100554 0.114668407665744 no 3018 0.106270229750916 4284 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_685 1278-0033 54.9 µM -1.24858567584063 0.114301333402797 no 3019 0.105908327076464 4404 3590572
SGTC_1017 4239-0030 168 µM -1.25575007167018 0.112977098043429 no 3020 0.104603299431236 4345 1149593
SGTC_589 1227-0070 34.1 µM -1.25817907214191 0.112530627628802 no 3021 0.104163500888316 4383 2841384
SGTC_3241 9133421 49.47 µM -1.25925302700426 0.112333628152071 no 3022 0.103969476920917 4411 17018221
SGTC_602 3130-1533 38.1 µM -1.26075845009376 0.112057897888559 no 3023 0.103697943955397 4380 720941
SGTC_2614 arthonioic acid 13.39 µM -1.26242976623392 0.111752350134063 no 3024 0.103397091972788 4188 6710684
SGTC_935 2996-0153 430 µM -1.26361702375931 0.111535659655115 no 3025 0.103183760155859 4333 23738523
SGTC_1149 3909-7961 23.3 µM -1.26436373974301 0.111399528044484 no 3026 0.10304975067613 4398 735261
SGTC_154 3389-1638 511.116 µM -1.27038121141918 0.110306839501591 no 3027 0.101974436291902 4342 5238686
SGTC_133 0724-0033 378.92 µM -1.27185652955387 0.110040119575197 no 3028 0.101712049725344 4173 280309
SGTC_517 1365-0151 113 µM -1.2722667837771 0.109966032796241 no 3029 0.10163917309136 4361 768657
SGTC_1782 st039423 80.636 µM -1.27881412990804 0.108788504676581 no 3030 0.100481258460907 4377 2068169
SGTC_920 mycophenolic acid 780.421 nM -1.2812031386237 0.108361111635779 no 3031 0.100061161996409 4327 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_230 MPP+ 141.667 µM -1.28350935065872 0.107949678346674 no 3032 0.0996568428686241 4314 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_75 0159-0059 199.013 µM -1.28610920699689 0.107487208557823 no 3033 0.0992024756709805 4429 5377270
SGTC_2727 riluzole 51.77 µM -1.28985494189813 0.106823419888413 no 3034 0.0985505138183682 4390 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2138 5575593 77.673 µM -1.29170531190585 0.106496605999747 no 3035 0.0982296086043576 4363 762213
SGTC_1759 st043059 70 µM -1.2933444956373 0.106207695512799 no 3036 0.0979459688675219 4365 669426
SGTC_1385 3091-4834 14.1 µM -1.29895706983119 0.105222753107624 no 3037 0.0969793312414078 4349 4072814
SGTC_1433 4060-0023 7.6 µM -1.29904240011764 0.105207829798704 no 3038 0.0969646892904647 4389 3840627
SGTC_3303 9125618 40.5795 µM -1.30459417911142 0.104240174826553 no 3039 0.0960155357055356 4383 22695467
SGTC_972 1319-0219 195 µM -1.30632873701914 0.103939174389869 no 3040 0.0957203942955074 4356 23903702
SGTC_353 1988-1175 58.3 µM -1.31558921273725 0.102342852221486 no 3041 0.0941559780655692 4212 2788357
SGTC_995 3931-2021 34.6 µM -1.32008913737114 0.101573623413705 no 3042 0.0934026295398295 4381 730143
SGTC_271 rotenone 740 µM -1.32237164995528 0.101185058094376 no 3043 0.0930222122132864 4414 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3330 9141424 71.43 µM -1.323796574434 0.100943034788912 no 3044 0.0927853070656145 4405 27261020
SGTC_3022 9087993 49.47 µM -1.32444423431525 0.100833169424116 no 3045 0.0926777760050552 4459 17173644
SGTC_2353 9059630 146.67 µM -1.3255358835438 0.100648185596331 no 3046 0.0924967379855708 4415 4779114
SGTC_2681 menadione 3.18 µM -1.3278563091645 0.100255803794822 no 3047 0.0921127903120922 4414 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1341 1486-1360 280 µM -1.32833970889824 0.100174202072746 no 3048 0.0920329536174873 4368 3976547
SGTC_1044 1222-0021 1.78 µM -1.33061110509116 0.0997914214472357 no 3049 0.0916585032787799 4310 4306703
SGTC_1567 st069303 68.4 µM -1.33664947194826 0.098779020788935 no 3050 0.0906685411953083 4419 5581319
SGTC_152 4469-0003 551.229 µM -1.34028942648569 0.0981723835173297 no 3051 0.0900756338488621 4376 697280
SGTC_1838 st055369 84.5 µM -1.34082521310238 0.0980833198917612 no 3052 0.0899886040573582 4375 676036
SGTC_3053 9095903 49.47 µM -1.34227213232111 0.0978430948464397 no 3053 0.0897538878832893 4507 17174018
SGTC_1683 st010134 710 nM -1.34357511328241 0.0976271364721779 no 3054 0.0895429107908643 4374 3818134
SGTC_3348 9149464 3.537 µM -1.34612967746532 0.0972047532272593 no 3055 0.0891303495663281 4340 1951442
SGTC_2423 st077119 87.2 µM -1.34625525857466 0.0971840237119354 no 3056 0.0891101048016387 4325 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3203 9113543 49.47 µM -1.34633899116332 0.0971702038818703 no 3057 0.0890966082833824 4432 17018012
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.3478680796658 0.0969180856810161 no 3058 0.0888504081721742 4515 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1343 1487-0095 224 µM -1.34958686149466 0.0966352642866403 no 3059 0.0885742704450649 4403 4560101 YGL055W OLE1
SGTC_216 k038-0035 28.382 µM -1.35084943223885 0.0964278978704146 no 3060 0.0883718347675918 4317 4444231 YPR107C YTH1
SGTC_2312 7706453 155.7 µM -1.35433543484622 0.0958570498656606 no 3061 0.0878146930068244 4397 976098
SGTC_523 1934-0222 13.7 µM -1.35686849818734 0.0954438118001029 no 3062 0.0874114989401819 4355 1361595
SGTC_1608 st001473 40.5 µM -1.35757242338899 0.095329208248506 no 3063 0.0872996991261354 4349 7292267
SGTC_2106 5357045 167.29 µM -1.35766705053154 0.09531381006899 no 3064 0.0872846782624652 4433 668842
SGTC_120 rhodamine 6G 52.259 µM -1.3579974213691 0.0952600649088839 no 3065 0.0872322511928382 4420 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2756 carbadox 75.1 µM -1.35940087885363 0.0950319973423557 no 3066 0.0870097963897341 4344 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_899 1083-0020 478 µM -1.36150752094221 0.0946904147566283 no 3067 0.0866766792028272 4457 767123
SGTC_2428 5615643 7.78 µM -1.36222055258646 0.0945750050880896 no 3068 0.0865641457586706 4392 2253075
SGTC_2868 9035608 32.47 µM -1.36464168609941 0.094183899808275 no 3069 0.0861828480066581 4385 6462614
SGTC_817 1391-0715 46 µM -1.36777616746118 0.0936793355749207 no 3070 0.085691074916982 4389 1353946
SGTC_2241 6772625 37.8075 µM -1.36785974509108 0.0936659092735294 no 3071 0.0856779911227133 4211 2285411
SGTC_178 4092-0806 87.505 µM -1.36850028207384 0.0935630575843235 no 3072 0.0855777668835683 4298 2169044
SGTC_1181 1222-0449 220 µM -1.37318753801374 0.0928129571192355 no 3073 0.0848470264142546 4478 658318
SGTC_1681 tripelennamine 100 µM -1.37495947348667 0.0925305559877364 no 3074 0.0845720046330121 4322 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1645 Cervolide 78 µM -1.3802192810144 0.0916960220868297 no 3075 0.0837595695859906 4429 23173 A fragrance.
SGTC_361 000s-0510 1.45 µM -1.38119852000564 0.0915412713015953 no 3076 0.0836089648594682 4328 660
SGTC_2026 5148700 152 µM -1.38124774417253 0.0915334974358789 no 3077 0.0836013996692126 4403 79838
SGTC_254 nsc-64875 3.808 µM -1.38304136353105 0.0912505686316838 no 3078 0.0833260916198264 4412 56993
SGTC_1202 1988-0068 29.6 µM -1.38353968758854 0.0911720773045655 no 3079 0.083249723470132 4394 2850480
SGTC_337 1315-0038 354 µM -1.39686920891736 0.0890910765254368 no 3080 0.0812264527069039 4403 1626437
SGTC_2293 7624732 200 µM -1.39852438144271 0.0888351589784313 no 3081 0.0809778281543919 4325 894453
SGTC_2269 7935389 174.42 µM -1.39879702556836 0.0887930561652061 no 3082 0.0809369292627392 4428 97605
SGTC_492 tmb-8 126 µM -1.40145338642929 0.0883836274801842 no 3083 0.0805392686854309 4464 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_833 3852-0053 558 µM -1.40396248832901 0.0879981895547322 no 3084 0.0801650100484879 4501 3123681
SGTC_994 3910-0338 138 µM -1.40973312809162 0.0871164859258817 no 3085 0.0793092494361925 4509 3479481
SGTC_956 1185-0240 191 µM -1.41507525677706 0.0863061513535831 no 3086 0.0785232160000391 4421 1416193
SGTC_773 4358-1457 44.6 µM -1.41714208025411 0.0859941567991565 no 3087 0.0782206958397918 4437 1186886
SGTC_1991 st073000 8.92 µM -1.41720015831746 0.0859854019098579 no 3088 0.0782122077625469 4479 4301969 YIL048W NEO1
SGTC_2157 5649910 96.377 µM -1.41786721160838 0.0858848957923555 no 3089 0.0781147683718663 4427 2858091
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.41814492612966 0.0858430779783012 no 3090 0.0780742285580437 4485 65057 A dermal irritant. YDR527W RBA50
SGTC_2854 9024559 71.43 µM -1.41910823000939 0.0856981433095962 no 3091 0.0779337324568006 4455 3163529
SGTC_1928 4'-methoxychalcone 40.3 µM -1.42660814796287 0.0845759967803454 no 3092 0.0768464371572904 4466 641818
SGTC_2251 lansoprazole 556 µM -1.42963061722587 0.0841269004332083 no 3093 0.0764115316468786 4412 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1418 3966-3099 2.4 µM -1.43025367325455 0.0840345460426316 no 3094 0.0763221128726452 4451 740335
SGTC_1917 st066507 28.5 µM -1.43179244848476 0.0838067825474045 no 3095 0.0761016145376698 4401 3156428
SGTC_1261 0712-0010 12.7 µM -1.43241472063307 0.0837148080377845 no 3096 0.0760125840668566 4433 2840123
SGTC_3167 9103034 49.47 µM -1.43488333339667 0.0833506834206644 no 3097 0.0756601728913517 4542 5127859
SGTC_2923 7992654 58.14 µM -1.43866445002227 0.0827952723794046 no 3098 0.0751228081193089 4446 2985126
SGTC_3004 9076122 71.4286 µM -1.44225844487981 0.0822699336074628 no 3099 0.0746147392077663 4463 44782551
SGTC_452 diindolylmethane 8 µM -1.44981462512171 0.0811736302476545 no 3100 0.0735551100078402 4467 3071 Inhibits expression of several cancer promoting factors.
SGTC_2292 7671323 168.05 µM -1.45072222083882 0.0810426949799523 no 3101 0.0734286126666994 4484 937504
SGTC_1983 st071813 46.9 µM -1.4518894736685 0.0808745344081803 no 3102 0.0732661699452019 4532 11838595
SGTC_2895 9054447 58.44 µM -1.45419576941568 0.0805430519574204 no 3103 0.0729460187955774 4532 2697450
SGTC_1845 st056753 3.01 µM -1.45425341467555 0.0805347798065204 no 3104 0.0729380304401829 4433 5375839
SGTC_3206 9114350 49.47 µM -1.45524974389904 0.0803919069791856 no 3105 0.072800067074632 4329 17087243
SGTC_3204 9114183 49.47 µM -1.45550945103742 0.0803546966648473 no 3106 0.0727641378439654 4425 17027248
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.45744716340224 0.0800774758412788 no 3107 0.0724964931116529 4451 689007
SGTC_3305 9127027 53.8275 µM -1.45890912745955 0.0798687974412672 no 3108 0.0722950603028724 4415 41905295
SGTC_2635 hydroquinidine 100 µM -1.46375075622532 0.079180647057246 no 3109 0.0716310308924243 4397 442912 An experimental heart treatment.
SGTC_2799 7812892 81.82 µM -1.46979994244379 0.0783271841742484 no 3110 0.0708079723819428 4497 20205235
SGTC_1275 0867-0008 21.1 µM -1.47059650041736 0.0782153217650914 no 3111 0.0707001354707292 4454 3422836
SGTC_3097 9117246 49.47 µM -1.47540099632185 0.0775431836539097 no 3112 0.0700523838375377 4500 16423892
SGTC_777 1315-0167 517 µM -1.47897029366735 0.0770466931916517 no 3113 0.0695741272355003 4503 4221767
SGTC_2036 5160441 105 µM -1.48331669818758 0.0764453734880354 no 3114 0.068995143947307 4455 134534 YIL048W NEO1
SGTC_1105 epirubicin 18.1 µM -1.48347659310065 0.0764233205082511 no 3115 0.0689739154292297 4519 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2146 5545642 200 µM -1.48691047711959 0.0759508806924707 no 3116 0.0685192283668165 4436 825326
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.48884823186125 0.0756852643156215 no 3117 0.0682636690858703 4527 1273210
SGTC_961 1252-1571 372 µM -1.49610371682972 0.0746970063442616 no 3118 0.0673133147488787 4513 6813498
SGTC_1649 st011737 51.3 µM -1.49613665490791 0.0746925424636502 no 3119 0.0673090238208141 4513 1761035
SGTC_1931 st074438 57.1 µM -1.49778701309807 0.0744691408289612 no 3120 0.0670942980198836 4494 2787313
SGTC_594 1487-1584 10.8 µM -1.50950056293119 0.0728981630626186 no 3121 0.0655854557742589 4466 5013332
SGTC_2735 sertaconazole 140 nM -1.51553372061874 0.0720989800552151 no 3122 0.0648186487410551 4634 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2929 9013348 24.6 µM -1.51591498268669 0.0720487026512964 no 3123 0.0647704256342423 4474 2995952
SGTC_389 tpck 16.7 µM -1.51682879820332 0.0719283063211857 no 3124 0.0646549570648733 4541 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_269 exalamide 29 µM -1.51837872120844 0.0717244548508731 no 3125 0.0644594763858423 4465 3316 A derivative of salicylamide.
SGTC_2105 5350118 200 µM -1.52699554969731 0.0705992101615013 no 3126 0.0633810590008814 4485 2133313
SGTC_1252 0493-0875 34.8 µM -1.52714141769473 0.0705802791806347 no 3127 0.0633629248948473 4505 3960963
SGTC_138 0850-0259 40.9225 µM -1.53497064438119 0.0695699036618749 no 3128 0.0623955195011294 4464 6813004
SGTC_2621 lithochol-11-enic acid 100 µM -1.53985877532219 0.0689447518985182 no 3129 0.0617973906994877 4460 6708711
SGTC_2378 9074213 121.43 µM -1.54070010881284 0.0688375904104527 no 3130 0.061694895163178 4491 657714
SGTC_3187 9109394 49.47 µM -1.54602171629159 0.0681627444679767 no 3131 0.0610496616168191 4519 17098090
SGTC_2208 7283366 200 µM -1.54616837378376 0.0681442190420606 no 3132 0.0610319546811803 4506 898663
SGTC_595 3909-8003 73.7 µM -1.54741835797397 0.0679864817002302 no 3133 0.0608811986441443 4575 699517
SGTC_2643 anethole 100 µM -1.55224873039453 0.0673795785036091 no 3134 0.0603013601120597 4529 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_664 1222-0054 14.9 µM -1.55317367257731 0.0672638450242054 no 3135 0.0601908246149778 4493 6813991
SGTC_506 n9-isopropylolomoucine 153 µM -1.55486407626871 0.0670527302623893 no 3136 0.0599892223130795 4525 6610355
SGTC_468 gf-109203x 121 µM -1.55964260612053 0.0664587105207837 no 3137 0.0594221810621267 4605 2396 A protein kinase C inhibitor.
SGTC_249 wiskostatin 11.211 µM -1.56036162126459 0.0663696833707638 no 3138 0.0593372244551067 4484 2775510 A n-wasp and actin depolymerizer.
SGTC_470 aa-861 153 µM -1.56148375748224 0.0662309270565261 no 3139 0.0592048266314302 4473 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_571 k831-0106 44.2 µM -1.56319299554513 0.0660200053109478 no 3140 0.05900360357751 4424 4783639
SGTC_552 k242-0005 476 µM -1.5641526948578 0.065901805776258 no 3141 0.0588908567141836 4566 4088318
SGTC_1154 4088-0362 150 µM -1.56742730394058 0.0654997289790121 no 3142 0.0585074230116152 4533 6618304
SGTC_1061 3448-9325 110 µM -1.56911397740392 0.0652933724037359 no 3143 0.0583106917305909 4499 723482
SGTC_2729 fluphenazine 10.66 µM -1.57399884949527 0.0646985763570529 no 3144 0.0577438577101445 4499 3372 An atypical antipsychotic.
SGTC_2331 7980721 200 µM -1.5755821305507 0.0645066971363912 no 3145 0.0575610684934155 4502 2981221
SGTC_567 1080-0542 68.4 µM -1.57673926522855 0.0643667428041253 no 3146 0.0574277658043689 4425 5950415
SGTC_2238 6671620 73.2395 µM -1.57909588498097 0.0640824416138615 no 3147 0.057157032711707 4451 729941
SGTC_2315 7733312 200 µM -1.59304192671832 0.0624199383240747 no 3148 0.0555753928698299 4449 726316
SGTC_1162 k048-0130 20.1 µM -1.59535359451952 0.0621476439150092 no 3149 0.0553165935084765 4539 6797406
SGTC_2472 5377652 49.4 µM -1.60212672508242 0.0613551613373724 no 3150 0.0545637946531683 4585 1610903
SGTC_2139 5578692 56.4705 µM -1.61066369772279 0.0603675742858507 no 3151 0.0536265210761778 4541 650991 YMR113W FOL3
SGTC_2864 9034755 47.6 µM -1.61155321435987 0.0602653916376032 no 3152 0.0535295992728991 4498 4930451
SGTC_2654 protoveratrine a 100 µM -1.61241229581063 0.0601668337751966 no 3153 0.0534361254851054 4552 5702278 A heart drug and vasodilator.
SGTC_3184 9108758 49.47 µM -1.61325841442776 0.0600698864577459 no 3154 0.0533441886163482 4597 902885
SGTC_2760 etidronate 98.04 µM -1.61353515873255 0.0600382039667475 no 3155 0.0533141455808925 4512 3305 A chelator and antioxidant.
SGTC_530 4358-1714 28 µM -1.61687545214204 0.059656828789123 no 3156 0.0529525841159406 4535 1564641
SGTC_654 1124-0271 80.9 µM -1.61790971405117 0.0595391284855913 no 3157 0.0528410282533837 4555 5403748
SGTC_3310 9130229 44.1445 µM -1.63322450779428 0.0578175057017992 no 3158 0.051210893676007 4571 7761258
SGTC_835 0312-0010 67.2 µM -1.63809898761948 0.0572778258023283 no 3159 0.0507005230781838 4586 1626196
SGTC_1557 sumaresinolic acid 42.3 µM -1.63961805329675 0.057110454490292 no 3160 0.0505423035096349 4544 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_822 1487-0950 154 µM -1.64991862484898 0.0559856684567054 no 3161 0.0494797904160259 4559 1958375
SGTC_2091 4-phenylthiadiazole 200 µM -1.65062166617337 0.055909540378807 no 3162 0.0494079259880907 4581 270010
SGTC_781 4335-2806 94.4 µM -1.65533065520609 0.0554017358704908 no 3163 0.0489287219398422 4600 845254
SGTC_1802 st050112 57.9 µM -1.6567159814794 0.0552530413924815 no 3164 0.0487884551910918 4579 4662563
SGTC_1735 st034310 56.75 µM -1.66626192823399 0.0542369763109949 no 3165 0.0478306280757342 4577 871153
SGTC_2252 omeprazole 400 µM -1.66986010855863 0.0538578467828745 no 3166 0.0474735222462222 4604 4594 A proton pump inhibitor.
SGTC_2337 9009472 200 µM -1.67226390540275 0.0536057372550658 no 3167 0.0472361469143074 4534 5742383
SGTC_400 oxethazaine 37.5 µM -1.67341355649791 0.0534854931072531 no 3168 0.0471229554639815 4599 4621 A local anesthetic.
SGTC_3163 9099914 49.47 µM -1.67673531686692 0.0531392645777612 no 3169 0.0467971256292106 4668 16268368
SGTC_2133 5320837 200 µM -1.6817882500888 0.0526160052693123 no 3170 0.0463049539860655 4592 2841355
SGTC_2907 7721985 69.9 µM -1.68244645572119 0.0525481464751862 no 3171 0.046241149755428 4578 3267881
SGTC_1345 1488-0192 31.4 µM -1.68731292546748 0.0520485827823541 no 3172 0.045771598458873 4622 658348
SGTC_2354 9060492 162 µM -1.69002919518789 0.0517713912388663 no 3173 0.0455111846723087 4576 6471895
SGTC_1534 6-azauridine 81.6 µM -1.69108216925093 0.0516642528071845 no 3174 0.0454105550998155 4624 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_163 TUB2.036 7.546 µM -1.69410711591031 0.0513574496075527 no 3175 0.0451224651944576 4535 15992207 YJR013W GPI14
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.69679378462843 0.0510861728200504 no 3176 0.0448678271186763 4659 688801
SGTC_87 0100-0052 35.5 µM -1.69965478097178 0.0507985489584629 no 3177 0.0445979398180069 4602 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_704 1310-0270 142 µM -1.69977419259321 0.0507865722679819 no 3178 0.0445867038133045 4570 5718033
SGTC_1382 3002-2117 298 µM -1.70823983195868 0.0499432042061598 no 3179 0.0437959252174207 4629 1497314
SGTC_1949 st076024 69.1 µM -1.70870853090997 0.0498968395295422 no 3180 0.0437524765519338 4558 2921930
SGTC_3192 9110362 49.47 µM -1.71462504872828 0.0493145123103561 no 3181 0.0432069966123312 4579 16649480
SGTC_3229 9132204 49.47 µM -1.72067937092533 0.0487242521278874 no 3182 0.0426545108866308 4682 17682924
SGTC_3248 9135562 49.47 µM -1.72313803474084 0.0484861652632336 no 3183 0.0424317830665581 4587 17650701
SGTC_767 0929-0023 86 µM -1.72626403644596 0.0481848005088567 no 3184 0.0421499611144218 4622 1204563
SGTC_710 3448-4187 58 µM -1.73506110598365 0.0473447495621387 no 3185 0.0413649912164487 4566 3946412
SGTC_1192 1488-0095 21.4 µM -1.73799446333047 0.0470672605204424 no 3186 0.041105894681479 4625 915875
SGTC_3050 9093513 49.47 µM -1.73829105957249 0.0470392759194577 no 3187 0.0410797704549309 4563 25236664
SGTC_7 0192-1582 4.227 µM -1.74033263205632 0.0468470102185248 no 3188 0.0409003136414922 4647 252616
SGTC_1575 cyproterone acetate 48 µM -1.74347321122988 0.0465524764076524 no 3189 0.040625494855438 4593 9880 An androgen receptor antagonist and liver toxin.
SGTC_1410 3909-8106 77.9 µM -1.7537392366202 0.0456000509300339 no 3190 0.0397375995333116 4646 1039210
SGTC_2053 5265679 138 µM -1.75382606301897 0.0455920629727924 no 3191 0.0397301578625761 4524 764595
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.75920726329255 0.0450991884713131 no 3192 0.0392711555187793 4604 641818 YHR062C RPP1
SGTC_2734 clemastine 41.6 µM -1.75954134085614 0.045068731578338 no 3193 0.0392428024377807 4673 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1429 4049-0205 9.46 µM -1.76062445503243 0.044970100982323 no 3194 0.0391509933458917 4653 22774478
SGTC_462 ag-879 158 µM -1.76292028815166 0.0447616121630529 no 3195 0.0389569673682012 4609 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3072 9116419 49.47 µM -1.76328606836561 0.0447284669880656 no 3196 0.0389261269004793 4613 17170162
SGTC_666 0272-0154 136 µM -1.76788967042756 0.0443129990303325 no 3197 0.0385396750016026 4602 6870312
SGTC_2210 7115885 190.385 µM -1.77003033448641 0.0441208696351836 no 3198 0.0383610437746802 4690 2927039
SGTC_2344 7990960 76.95 µM -1.77257104627094 0.0438937072678211 no 3199 0.0381499064974883 4598 140813
SGTC_2512 diallyl trisulfide 49.23 µM -1.77625495511506 0.0435660093787267 no 3200 0.0378454520170184 4647 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2585 alliin 100 µM -1.77839026571541 0.0433769710206063 no 3201 0.0376698901601601 4617 87310 A garlic compound which reacts with lipids.
SGTC_2533 agelasine 13.65 µM -1.78288530153164 0.0429811913350567 no 3202 0.0373024881107487 4628 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2824 7998404 51.95 µM -1.78553896257879 0.0427489143495683 no 3203 0.0370869686664741 4601 837851
SGTC_505 gw-5074 63.9 µM -1.79608087702992 0.0418361760334674 no 3204 0.0362408276396291 4613 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3169 9102970 49.47 µM -1.79697934564232 0.0417591203418844 no 3205 0.0361694493973065 4676 17027839
SGTC_1817 st052116 64.4 µM -1.80084306634166 0.0414290636148993 no 3206 0.0358638093773464 4641 4361398
SGTC_1792 st045773 43.6 µM -1.80569041177255 0.0410179744219665 no 3207 0.0354833555945588 4607 2919270
SGTC_125 0133-0007 11.75 µM -1.81100558139457 0.040571019542052 no 3208 0.0350699938498626 4699 26541
SGTC_3046 9092212 49.47 µM -1.81358412050211 0.0403556176330009 no 3209 0.0348708885028895 4686 25236637
SGTC_2817 7995342 71.43 µM -1.82326102758758 0.0395555122437082 no 3210 0.034131932967036 4607 18879975
SGTC_581 0958-0271 211 µM -1.82447576797873 0.0394559929425433 no 3211 0.0340400882487124 4641 4591145
SGTC_876 0720-0963 56.8 µM -1.82506025514094 0.0394081806492406 no 3212 0.033995968514556 4640 765861
SGTC_2706 st078239 82.5 µM -1.83014040751249 0.0389945957434771 no 3213 0.0336144730233016 4620 15434492
SGTC_2505 galangin 7.89 µM -1.83196184303134 0.0388471726887342 no 3214 0.0334785528304608 4583 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1941 st076221 61.8 µM -1.84222908100388 0.0380246343432404 no 3215 0.0327208241688824 4529 2828568
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.84379966712802 0.0379000721839403 no 3216 0.0326061706297573 4601 6857784
SGTC_671 0560-0003 407 µM -1.84416917705205 0.0378708150269043 no 3217 0.0325792444293878 4618 3238678
SGTC_914 3820-6779 408 µM -1.84462288528452 0.0378349164040918 no 3218 0.0325462077824295 4565 2893481
SGTC_3171 9103192 49.47 µM -1.85024557247376 0.0373923345420242 no 3219 0.032139081665709 4692 13018434
SGTC_2086 5274770 176.623 µM -1.85223238121966 0.03723696044061 no 3220 0.0319962304017888 4666 689278
SGTC_2488 5268135 45.7 µM -1.85224744233819 0.0372357846358783 no 3221 0.0319951495152077 4658 1270356 YLR208W SEC13
SGTC_2766 oltipraz 83.91 µM -1.85520907058863 0.037005162419588 no 3222 0.031783188447808 4624 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1840 st055363 71 µM -1.86032546047918 0.0366095003949613 no 3223 0.0314197467460238 4655 676033
SGTC_2369 9071472 200 µM -1.8605168817813 0.0365947647761089 no 3224 0.0314062161326872 4658 17296037
SGTC_1163 k060-0048 49.9 µM -1.86963098595808 0.0358987568688091 no 3225 0.0307675396381191 4659 6809982
SGTC_347 4534-1311 26.2 µM -1.87087581562707 0.0358045414859442 no 3226 0.0306811479279605 4655 2862016
SGTC_406 estrone 100 µM -1.87235311896675 0.035692994245415 no 3227 0.0305788831845573 4633 5870 A steroid.
SGTC_918 glabranin 770.725 nM -1.87530427433516 0.0354710131311715 no 3228 0.0303754378365074 4641 124049 Also referred to as licorice root.
SGTC_2888 9058547 12.99 µM -1.88071833331549 0.0350667199758457 no 3229 0.0300051222092966 4590 16476514
SGTC_2762 leflunomide 42.06 µM -1.88865085665857 0.0344811973900939 no 3230 0.0294693138209392 4622 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1301 naphtanilide LB 4.81 µM -1.89600828298229 0.0339453275015046 no 3231 0.0289794746307919 4695 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_118 0083-0097 135.343 µM -1.89711794343446 0.0338651042299044 no 3232 0.0289061867595812 4629 5207356
SGTC_1833 st055984 71 µM -1.89719165219037 0.0338597809594119 no 3233 0.0289013241030457 4677 676288
SGTC_2731 amoxapine 43.43 µM -1.89865092818498 0.0337545332060197 no 3234 0.0288051937818431 4767 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_694 1315-0438 43.2 µM -1.902106267592 0.0335063958197241 no 3235 0.0285786316259772 4692 6793154
SGTC_1172 0370-0043 85 µM -1.90259774716487 0.0334712236183172 no 3236 0.0285465266738184 4674 376585
SGTC_1051 3253-3903 78 µM -1.91288527498189 0.0327419579673495 no 3237 0.0278813705282524 4668 5509239
SGTC_2323 6148992 148.28 µM -1.92946549138512 0.0315942195937488 no 3238 0.0268365500663105 4638 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2131 toluylene red 5.2905 µM -1.93190253949067 0.0314283559068406 no 3239 0.0266857681468173 4630 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1933 st074711 15.9 µM -1.93192303507958 0.0314269640508185 no 3240 0.0266845030765776 4668 17250958
SGTC_1042 0350-0096 82 µM -1.93334466586633 0.0313305453528717 no 3241 0.0265968764568338 4653 3122515
SGTC_105 0111-0055 734.78 µM -1.93796091132853 0.0310191449660063 no 3242 0.0263139958202527 4676 5179370
SGTC_1947 st076332 61.6 µM -1.94015976098628 0.0308717190331228 no 3243 0.0261801385414311 4553 24208416
SGTC_38 0929-0051 58.268 µM -1.94707443000435 0.0304118873331291 no 3244 0.0257629060198746 4625 1379719
SGTC_2005 4024620 188 µM -1.95957236983984 0.029595163170925 no 3245 0.0250228967339839 4628 236743
SGTC_1966 st070145 16.1 µM -1.96195432662977 0.029441589347919 no 3246 0.0248839009926348 4664 3748532
SGTC_1594 piperine 70.1 µM -1.96257753111778 0.029401518360257 no 3247 0.024847641818778 4655 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2339 9000433 200 µM -1.97053188101433 0.0288940329743306 no 3248 0.0243887224466348 4629 2988954
SGTC_1331 1472-0049 76.2 µM -1.97311270998088 0.0287309494658798 no 3249 0.0242413612611961 4669 24051409
SGTC_1868 st057644 42.7 µM -1.98515858885091 0.0279798566659448 no 3250 0.0235634150020008 4693 688665
SGTC_2436 5633522 8.09 µM -1.98866566825568 0.0277642797884514 no 3251 0.0233690589170819 4666 5724242
SGTC_1956 st077085 54 µM -1.99377217497283 0.0274528637180426 no 3252 0.0230884788512857 4684 24208685
SGTC_2112 5488546 200 µM -1.99394236984723 0.0274425348827115 no 3253 0.0230791764538142 4662 600757
SGTC_1340 1486-1359 257 µM -1.9964366058852 0.027291535325038 no 3254 0.0229432098279845 4659 4309068
SGTC_2807 7945238 51.95 µM -2.00033318186592 0.0270570263645509 no 3255 0.022732149129761 4651 17148797
SGTC_1040 k898-0338 155 µM -2.00840001352769 0.0265768794597278 no 3256 0.0223004007360488 4665 20969351
SGTC_360 0957-0399 1.01 µM -2.02201010843164 0.025782934090364 no 3257 0.0215876537908889 4684 6752301 YPR165W RHO1
SGTC_2862 9027634 71.43 µM -2.03428412911005 0.0250840450624855 no 3258 0.02096147821171 4660 5012562
SGTC_2374 9071832 200 µM -2.03975155500618 0.0247778780179209 no 3259 0.0206875385843464 4661 17381698
SGTC_511 blebbistatin 171 µM -2.04169859291371 0.0246696066645441 no 3260 0.0205907192191644 4701 3476986 A myosin inhibitor.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.04463831602646 0.0245068861180811 no 3261 0.0204452645305317 4673 115019
SGTC_611 3453-1652 23.7 µM -2.05234288268396 0.0240846897249501 no 3262 0.0200681756153324 4685 1560575
SGTC_842 0271-0008 11.1 µM -2.05447606498416 0.0239688811511401 no 3263 0.0199648188210558 4700 1221709
SGTC_970 1315-0089 19.5 µM -2.06058713310803 0.0236397043310851 no 3264 0.0196712226632381 4685 6811083 YLR033W RSC58
SGTC_2475 5812728 15.03 µM -2.07239223739055 0.0230145749318853 no 3265 0.0191144383529508 4666 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_77 0828-0286 12.516 µM -2.09414787812413 0.0218989743820397 no 3266 0.018123404580127 4620 745345
SGTC_2229 7354935 190 µM -2.09434290484272 0.0218891839426724 no 3267 0.0181147224564686 4705 318112
SGTC_1013 4112-3890 241 µM -2.09970653098062 0.0216213723374852 no 3268 0.0178773323636781 4695 705171
SGTC_2313 7726885 200 µM -2.10134366588997 0.0215401820187864 no 3269 0.0178054046246956 4696 726423
SGTC_3247 9135149 49.47 µM -2.10420245784487 0.0213990239654211 no 3270 0.0176803951192097 4716 8934436 YOR116C RPO31
SGTC_2142 5622915 118.518 µM -2.11246048775347 0.0209956540410904 no 3271 0.0173234857847736 4715 5322196
SGTC_1731 st035964 63 µM -2.11738517958839 0.0207581804296355 no 3272 0.0171135854839284 4617 6739575
SGTC_769 0302-0231 76 µM -2.12119395702907 0.0205760806310801 no 3273 0.016952741801796 4649 571869 YER009W NTF2
SGTC_2588 indole-3-carbinol 100 µM -2.12633813386896 0.0203322842455467 no 3274 0.0167375575012705 4685 3712 Induces cell cycle arrest.
SGTC_327 1273-0057 3.96 µM -2.13947507592322 0.0197207757265071 no 3275 0.01619860618709 4663 3108138
SGTC_2011 4012611 177 µM -2.14604041303386 0.0194210647543782 no 3276 0.0159348772885042 4681 2049887
SGTC_3272 9137413 49.47 µM -2.1478526098452 0.019339021738206 no 3277 0.0158627330523221 4676 17614870
SGTC_2257 7960413 200 µM -2.15171734941022 0.0191650379583249 no 3278 0.0157098114224402 4739 2974689 YIL048W NEO1
SGTC_1781 st038725 66.3 µM -2.15290241062488 0.0191119558741564 no 3279 0.0156631745034856 4699 4270275 YIL048W NEO1
SGTC_2726 cimetidine 79.27 µM -2.1536459626091 0.0190787140395763 no 3280 0.0156339734329461 4736 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_22 0964-0034 14.468 µM -2.16342749438927 0.0186459704922767 no 3281 0.0152541573948908 4722 138402
SGTC_1745 st081495 74 µM -2.16624932251866 0.018522694021318 no 3282 0.0151460699851449 4613 13842402 YBL026W LSM2
SGTC_237 nikkomycin 200 µM -2.17063824456444 0.0183323356982649 no 3283 0.0149792643713439 4725 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_59 0330-0160 1.33 µM -2.17084018680063 0.0183236172216059 no 3284 0.0149716274939701 4674 4293482
SGTC_3191 9110352 49.47 µM -2.17373001176776 0.0181992409037551 no 3285 0.0148627086887093 4700 17122424
SGTC_947 3447-0010 211 µM -2.17870183708293 0.0179869401221318 no 3286 0.0146769126031603 4671 748350
SGTC_926 2268-1401 59.4 µM -2.18230414624265 0.0178344412367502 no 3287 0.0145435466068697 4695 2931578
SGTC_974 1326-0144 138 µM -2.20210948377297 0.0170155685494111 no 3288 0.0138287878676144 4732 5411856
SGTC_1723 st034307 2.5525 µM -2.20228531476922 0.017008445040037 no 3289 0.0138225804307703 4701 867466
SGTC_3331 9141060 1.957 µM -2.20650525032663 0.0168382443790862 no 3290 0.0136743215135862 4705 4906567 YPR165W RHO1
SGTC_2403 6032726 181.2 µM -2.21839634317294 0.0163664613698044 no 3291 0.0132639101229715 4707 2881040
SGTC_2058 5236698 133 µM -2.22174720544887 0.0162355767628492 no 3292 0.0131501972116013 4712 766665
SGTC_1473 k844-0725 134 µM -2.23295455752791 0.0158043124853305 no 3293 0.0127759706102227 4760 54682906
SGTC_1848 st056003 16.4 µM -2.25164055417843 0.0151071076398381 no 3294 0.0121724980445137 4720 146492
SGTC_2233 sulbentine 40.3845 µM -2.2568236586133 0.014918463841233 no 3295 0.0120095478973758 4738 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_878 0828-0289 13.7 µM -2.26664242158119 0.0145666488801694 no 3296 0.0117060392055352 4726 745350 YLR208W SEC13
SGTC_1570 verbenone 133 µM -2.26744134409878 0.0145383395060804 no 3297 0.0116816391332588 4726 29025 A natural terpanoid with antifungal properties.
SGTC_3273 9137859 49.47 µM -2.27033814732102 0.0144360896607495 no 3298 0.0115935370967305 4761 2377234
SGTC_3189 9110682 49.47 µM -2.29091697181288 0.0137273743855171 no 3299 0.0109841080970516 4718 17122418
SGTC_679 0422-0091 41.4 µM -2.30890752627152 0.0131325902343835 no 3300 0.0104743566317125 4748 627384 YHR062C RPP1
SGTC_2321 7390090 138.78 µM -2.3167749060918 0.012879568642019 no 3301 0.0102579983400699 4718 649046
SGTC_2189 6047310 154.431 µM -2.34661596352931 0.0119578015005552 no 3302 0.00947238497828354 4761 711535
SGTC_1721 st082152 9.2685 µM -2.37408098810828 0.0111605492897892 no 3303 0.0087963456114063 4722 5296051
SGTC_266 formosanin C 406 nM -2.38834095342405 0.0107651441025185 no 3304 0.00846231606433661 4654 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_129 0088-0017 176.636 µM -2.39803666344416 0.0105033147789896 no 3305 0.00824160764790121 4655 182446
SGTC_3037 9091026 49.47 µM -2.39976001787796 0.0104573616119123 no 3306 0.00820291175942333 4654 25236398 YIL048W NEO1
SGTC_1296 1068-0102 11.9 µM -2.41824979120581 0.00997525296035339 no 3307 0.00779768344966827 4762 767053
SGTC_2878 9043973 25.97 µM -2.43376077898697 0.00958589503145259 no 3308 0.00747143357967489 4728 6465167
SGTC_2732 terfenadine 20 µM -2.43613393894503 0.00952751080403306 no 3309 0.00742259327122899 4785 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2391 6285546 200 µM -2.4413718799289 0.00939974680884893 no 3310 0.00731578952488258 4752 846083
SGTC_467 ro 31-8220 72.8 µM -2.44240790823331 0.00937465425811983 no 3311 0.00729482570048232 4740 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1126 isoteolin 1.0172 µM -2.44843643678543 0.00922980290300631 no 3312 0.00717388716492382 4724 133323
SGTC_233 rapamycin 362 pM -2.4772362806974 0.00856451620016864 no 3313 0.0066202108216742 4764 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_507 nimesulide 162 µM -2.49073588336863 0.00826742251563504 no 3314 0.00637394221698003 4768 4495 A COX2 inhibitor.
SGTC_207 4185-0010 4.486 µM -2.50037093558653 0.0080609510097899 no 3315 0.00620316646928785 4760 3761753
SGTC_3228 9131799 49.47 µM -2.60185244588702 0.00614677674825754 no 3316 0.00463608681933459 4785 17015818
SGTC_2452 5863136 48.41 µM -2.63576020435738 0.00560364696161392 no 3317 0.00419745169380585 4744 2184096
SGTC_2405 ticlatone 3.52 µM -2.6701243400035 0.00509711640671144 no 3318 0.0037911581511872 4665 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2651 TUB2.036 5 µM -2.68061710152286 0.00495079365361908 no 3319 0.00367432739181153 4672 15992207 YFL037W TUB2
SGTC_3282 9108498 15.4605 µM -2.69792276571034 0.00471762684258675 no 3320 0.0034886813273551 4765 16459645
SGTC_2140 5586273 200 µM -2.71605218605439 0.00448391457953421 no 3321 0.00330327517155571 4781 854421
SGTC_2924 9010168 62.78 µM -2.73631859785385 0.00423494055623349 no 3322 0.0031065420010374 4757 2993929
SGTC_1963 st076565 50.3 µM -2.7653569492145 0.00389974246192284 no 3323 0.00284302690810707 4790 4914280
SGTC_123 0083-0120 66.675 µM -2.7723478449172 0.0038226819779593 no 3324 0.00278267653007992 4770 16001701
SGTC_439 amiodarone 34.4 µM -2.84284608012617 0.00311856587899615 no 3325 0.00223563290234341 4720 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2630 antimycin a 100 µM -2.85585849137839 0.00300217245689393 no 3326 0.00214603191329395 4752 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1818 st052136 56.3 µM -2.86311983025987 0.00293893649081378 no 3327 0.0020974594091277 4637 674169
SGTC_969 1313-0238 134 µM -2.86398409271815 0.00293149050167648 no 3328 0.00209174510077582 4789 5212874
SGTC_453 enantio-paf c16 10 µM -2.88587555121177 0.00274846776945125 no 3329 0.00195163232942587 4387 13871343 A lipid and platelet activating factor
SGTC_1957 st077035 62.4 µM -2.89581038392725 0.0026688626933055 no 3330 0.00189090416965404 4783 705593
SGTC_840 0245-0196 390 µM -2.94000309586271 0.00233940159751386 no 3331 0.00164104483747816 4802 3827528
SGTC_500 h-89 112 µM -2.9428570143784 0.00231944807158196 no 3332 0.00162599289688755 4785 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_883 0850-0245 24.6 µM -3.0120253866656 0.00188061594318914 no 3333 0.0012975544680386 4794 6823229 YPR165W RHO1
SGTC_1733 st037357 54.9 µM -3.044902482032 0.00169974517988324 no 3334 0.00116377883023424 4764 1272339 YGL099W LSG1
SGTC_1247 0448-0043 5.84 µM -3.05375470799858 0.0016538293328761 no 3335 0.00112998391516881 4768 3089013 YGL099W LSG1
SGTC_122 0236-0016 402.397 µM -3.0965712127481 0.00144728764811096 no 3336 0.000978864160381575 4789 6808838
SGTC_435 c-PAF 6.7 µM -3.10372661878649 0.00141516230733513 no 3337 0.000955499103143062 4751 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2858 9025781 8.96 µM -3.11662085996017 0.00135891062881025 no 3338 0.000914683384216714 4702 4894980 YPL153C RAD53
SGTC_2795 7780010 54.55 µM -3.26048262832984 0.000855957102118054 yes 3339 0.00055611390055088 4783 953673
SGTC_121 0557-0495 61.343 µM -3.26861263542759 0.000833445099110037 yes 3340 0.000540380757364089 4786 3104427
SGTC_358 0075-0058 9.45 µM -3.27063506503456 0.000827930242966865 yes 3341 0.000536531432008361 4773 1069125
SGTC_3263 9137018 49.47 µM -3.32334447461321 0.000695519725598961 yes 3342 0.00044472502197306 4789 43844957
SGTC_1676 st018489 23.4 µM -3.3380524941646 0.000662223910011639 yes 3343 0.000421839043760792 4799 3696235
SGTC_314 1671-0008 2.74 µM -3.34839199027303 0.000639704710143816 yes 3344 0.00040640978335252 4752 3913060
SGTC_2008 4012253 172 µM -3.52663527630424 0.000347253509102517 yes 3345 0.000210438049736098 4790 603940
SGTC_839 0122-0028 230 µM -3.57217630861517 0.000295758314381026 yes 3346 0.000177013464861498 4805 759448
SGTC_527 4476-4215 268 µM -3.60457024102115 0.000263557603460638 yes 3347 0.000156334940365239 4803 4418754
SGTC_683 panaxydol 45 µM -3.70797516611807 0.000181310355858718 yes 3348 0.000104461569580063 4801 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1934 st074720 32.6 µM -3.74736854312636 0.000156844937415709 yes 3349 8.9349717496735e-05 4789 17250992
SGTC_2700 st077718 96.8 µM -3.81184070476479 0.000123359714212555 yes 3350 6.89678813492885e-05 4803 904970
SGTC_299 1273-0059 1.44 µM -3.87761992662541 9.61915946363869e-05 yes 3351 5.27416673257791e-05 4725 2848077
SGTC_309 k408-0051 1.48 µM -4.26313940093118 2.07419774978843e-05 yes 3352 1.00787338605814e-05 4797 3640463
SGTC_2250 alverine citrate 130 µM -4.50094747350613 7.54264038607018e-06 yes 3353 3.38256119450406e-06 4780 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_310 1273-0058 1.06 µM -4.52868198395014 6.68150238497739e-06 yes 3354 2.96763749231009e-06 4674 2734232
SGTC_304 1310-0298 97 µM -4.62104023902519 4.44034187136576e-06 yes 3355 1.90910350956688e-06 4767 1550234
SGTC_58 0957-0393 9 µM -4.87167027191048 1.41028836600403e-06 yes 3356 5.53293681263199e-07 4687 6997992