SGTCid condition conc unit FDC1|YDR539W.score FDC1|YDR539W.strain.pval FDC1|YDR539W.strain.significant FDC1|YDR539W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2955 9076254 12.21 µM 6.79136687680902 2.34476090542444e-12 yes 1 5.55380260746717e-12 2 16459619 SGTC_2834 9001755 58.44 µM 6.57751756416466 1.06129752194474e-11 yes 2 2.39183682792957e-11 7 2989575 SGTC_3177 9107506 49.47 µM 6.31962525698985 6.16427608475693e-11 yes 3 1.31099174939264e-10 2 8897194 SGTC_565 1418-0001 44.5 µM 6.05646927308522 3.46274469489619e-10 yes 4 6.95708519459512e-10 1 2862145 SGTC_2327 6189656 200 µM 4.98355406891013 1.91358993531229e-07 yes 5 3.1213429415815e-07 8 5349088 SGTC_2829 7992743 58.44 µM 4.85452050633541 3.78342959937017e-07 yes 6 6.03391912086475e-07 18 16462845 SGTC_1183 1254-0324 198 µM 4.82535221851932 4.40356515439323e-07 yes 7 6.98780305480269e-07 8 5799357 SGTC_436 n,n-dimethylsphingosine 3.3 µM 4.81424494688003 4.66454508255336e-07 yes 8 7.38787412114672e-07 14 5282309 SGTC_654 1124-0271 80.9 µM 4.76050476228053 6.15226352661373e-07 yes 9 9.6554688684078e-07 9 5403748 SGTC_1316 1272-0050 65.9 µM 4.75727086544865 6.25503545887534e-07 yes 10 9.81138960784167e-07 2 7340392 SGTC_889 0919-1524 82.7 µM 4.51475495036943 2.10324660623472e-06 yes 11 3.16950105577704e-06 7 3905452 SGTC_588 3970-1144 52.9 µM 4.33153104028807 5.05759574323732e-06 yes 12 7.40380335066139e-06 20 1888707 SGTC_2033 5192550 145 µM 4.31448982550491 5.47834768132358e-06 yes 13 7.9985950457573e-06 8 182073 SGTC_664 1222-0054 14.9 µM 4.24707676264316 7.49402606167531e-06 yes 14 1.0828888588059e-05 31 6813991 SGTC_2659 sanguinarine 24.21 µM 4.12983430920299 1.27850281423975e-05 yes 15 1.81512384217194e-05 22 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_435 c-PAF 6.7 µM 4.08807959517468 1.54133097494075e-05 yes 16 2.17479463305354e-05 37 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1908 st060353 56.5 µM 4.08501203967458 1.56254104196462e-05 yes 17 2.20372655984922e-05 32 4227716 SGTC_584 0986-0246 15.4 µM 4.07437277622339 1.63827373103807e-05 yes 18 2.3069263581473e-05 11 53315 YDR232W HEM1 SGTC_2379 9035213 200 µM 3.95141803337758 2.80811674594697e-05 yes 19 3.8844740780575e-05 21 646551 SGTC_3306 9127676 59.7925 µM 3.87364806571324 3.91831960899489e-05 yes 20 5.36091074887812e-05 24 41905287 SGTC_598 3937-0236 20.2 µM 3.80383374685187 5.25754024577859e-05 yes 21 7.12369093373711e-05 31 1379313 SGTC_2063 5246145 200 µM 3.64024598820025 0.000102760717119952 yes 22 0.000136188848968311 31 711240 SGTC_3321 9137793 26.8275 µM 3.6375524052824 0.000103878112059085 yes 23 0.00013762060117217 87 4904192 SGTC_274 sirtinol 40.1 µM 3.59857244170297 0.000121380790359011 yes 24 0.000159984364003017 29 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_249 wiskostatin 11.211 µM 3.56828577592586 0.000136851135281381 yes 25 0.000179662234892009 22 2775510 A n-wasp and actin depolymerizer. SGTC_578 3460-0051 92 µM 3.45211753587104 0.000215015695544905 yes 26 0.000278102691968567 23 2876744 SGTC_2784 7567673 72.73 µM 3.40793112109863 0.000254451955845536 yes 27 0.000327287076993126 48 3471247 SGTC_884 0851-0618 334 µM 3.36777038771116 0.000296048020534625 yes 28 0.000378893393817254 32 9642473 SGTC_914 3820-6779 408 µM 3.31743270586887 0.000357124495647814 yes 29 0.000454243987841465 41 2893481 SGTC_684 1140-0066 328 µM 3.29818884531247 0.000383422848211376 yes 30 0.000486553321424049 63 6813534 SGTC_910 3454-3003 490 µM 3.24038464373121 0.000473621130886946 yes 31 0.000596842798151463 43 820824 SGTC_2329 6138490 200 µM 3.18938399496685 0.000569137228464037 yes 32 0.000712881749382559 69 720019 SGTC_2483 5729050 27.16 µM 3.18347720386223 0.000581282132545849 yes 33 0.000727587855558762 54 2865180 SGTC_1094 duloxetine 25.4 µM 3.17713663632398 0.000594585142861846 yes 34 0.000743684715879222 49 60834 A selective serotonin reuptake inhibitor. SGTC_489 paxilline 115 µM 3.17248837871084 0.000604515632759082 yes 35 0.000755693040566485 46 105008 A toxic potassium channel blocker. SGTC_1640 st009078 66.4 µM 3.11787684927184 0.000733234849885991 yes 36 0.000910794506286722 34 690618 SGTC_2141 5621638 7.665 µM 3.11201629166927 0.000748454569333422 yes 37 0.000929071222012257 58 2856238 SGTC_754 3474-0146 171 µM 3.08173402057828 0.000831838440666856 yes 38 0.00102899318491252 63 24762078 SGTC_2571 chrysanthemic acid 100 µM 3.07918286619026 0.000839239837281344 yes 39 0.0010378461540199 58 2743 An insecticide. SGTC_1229 0139-0193 12.2 µM 3.07182988671394 0.000860912532109663 yes 40 0.00106375466871532 45 3090752 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 3.07173504846798 0.000861195397054389 yes 41 0.00106409267542659 66 5355888 SGTC_2430 5571206 200 µM 3.04646268202295 0.000939693124963142 yes 42 0.00115775610169512 100 1731771 SGTC_1910 st062352 60.4 µM 3.04490581078649 0.00094473743544202 yes 43 0.00116376594999463 76 2245730 SGTC_1011 4112-3381 17.4 µM 3.0443635936541 0.000946500066730879 yes 44 0.00116586572010527 83 2877139 SGTC_2661 dactinomycin 12.96 µM 3.03371076686605 0.000981748522433008 yes 45 0.00120782952586287 61 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2664 lyso-paf C-16 73.48 µM 2.99266592638117 0.00112911984863801 no 46 0.00138276144950363 39 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1505 k297-0037 20.6 µM 2.96744784622706 0.0012294467419302 no 47 0.0015014161068075 65 4089396 SGTC_773 4358-1457 44.6 µM 2.94957586013762 0.00130541718709763 no 48 0.00159105221145392 92 1186886 SGTC_2550 chrysin dimethyl ether 71.87 µM 2.94566427819445 0.00132260681454066 no 49 0.00161130984104373 25 88881 An O-methylated flavonoid and antioxidant. SGTC_273 hydroxyurea 18.1 mM 2.93419440723265 0.00137421138201384 no 50 0.00167207338801724 75 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_50 0929-0078 56.389 µM 2.92667574707403 0.00140903003411354 no 51 0.00171302936256795 104 1377751 SGTC_1193 1488-0126 41.5 µM 2.90843842970959 0.00149685852477595 no 52 0.00181619347707323 62 1384710 SGTC_2744 captopril 92.04 µM 2.89526232114321 0.00156338976274551 no 53 0.00189420900292524 34 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_551 k048-0028 34.9 µM 2.8838204864239 0.00162333910643347 no 54 0.00196441322295679 67 6836383 SGTC_2437 5741531 144.16 µM 2.85189024169483 0.00180188088253335 no 55 0.00217300520270475 91 2262990 SGTC_2061 5245884 80.95 µM 2.79881384241231 0.00213853844905829 no 56 0.00256453490997345 76 573863 SGTC_2067 5224629 34.075 µM 2.79456936812069 0.00216778173706202 no 57 0.0025984445001054 86 2835000 SGTC_1941 st076221 61.8 µM 2.79394035931103 0.00217214614941307 no 58 0.00260350404592227 160 2828568 SGTC_784 4579-0127 173 µM 2.7713054937842 0.0023345994263613 no 59 0.00279160088790113 87 1948547 SGTC_670 4204-0025 119 µM 2.75410508593475 0.00246531965820543 no 60 0.00294264340094719 94 719039 SGTC_2475 5812728 15.03 µM 2.74238061016702 0.00255818054812957 no 61 0.00304978094894979 89 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2479 5617353 43.85 µM 2.71709295698971 0.00276931100344287 no 62 0.00329290539486294 103 2731746 SGTC_1849 st056239 19.2 µM 2.71212059774731 0.00281263076171589 no 63 0.00334271325239471 106 5393181 SGTC_1772 st048439 82.2 µM 2.70039819596403 0.00291718684011642 no 64 0.00346282645883051 100 2927068 YDL195W SEC31 SGTC_2885 9057732 51.95 µM 2.67380257767461 0.00316750593182596 no 65 0.00374982935142374 79 6471414 SGTC_768 0384-0033 77.3 µM 2.65863018934813 0.00331881666602101 no 66 0.00392295154285116 182 3965305 YMR134W ERG29 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.64385439091571 0.00347238671869035 no 67 0.00409839544587664 87 165521 SGTC_1066 ketoconazole 628 nM 2.63809181603816 0.00353398893569429 no 68 0.00416870023693754 97 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1276 0871-0068 94.2 µM 2.6342847042841 0.00357522365151511 no 69 0.00421573781893458 79 3414906 SGTC_2739 tacrine 100.86 µM 2.61306829504866 0.00381302765472287 no 70 0.00448666844841393 80 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_557 1315-0110 16.2 µM 2.60452204148516 0.00391275772899478 no 71 0.00460012515297294 115 6833801 SGTC_1735 st034310 56.75 µM 2.58137953822104 0.00419465159613817 no 72 0.00492031639727367 108 871153 SGTC_1016 4226-1401 38 µM 2.57955888464371 0.00421758110019598 no 73 0.00494632955292972 102 2901613 SGTC_62 0180-0423 3.232 µM 2.5792697731058 0.00422123249721255 no 74 0.00495047157836781 102 30102 YGL099W LSG1 SGTC_2605 digitonin 300 nM 2.5616321005516 0.00444940951654391 no 75 0.00520908064219114 136 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3308 9128332 17.569 µM 2.54573255413816 0.00466447618200143 no 76 0.00545243503019436 196 17332805 YDL196W YDL196W SGTC_2786 7743617 45.45 µM 2.53780864340795 0.004775084156336 no 77 0.00557744793947745 111 583674 SGTC_2402 5553605 200 µM 2.53572108353391 0.00480461045585889 no 78 0.00561080353719671 129 6758546 SGTC_728 3030-5151 22.5 µM 2.48954186403785 0.00550076189931465 no 79 0.0063953926847873 76 3125388 SGTC_49 0717-0965 32.132 µM 2.48116499023241 0.00563623494026746 no 80 0.00654768713875724 120 5889349 YGL099W LSG1 SGTC_1070 indatraline 8.81 µM 2.46394094440606 0.00592412961253741 no 81 0.00687093754859468 134 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1129 3453-1384 223 µM 2.4638157639573 0.00592626884255004 no 82 0.00687333755038768 161 1084452 SGTC_1635 st007035 42.4 µM 2.46163426330011 0.00596365902564956 no 83 0.00691528105223463 371 3716403 SGTC_1520 flindersine 88 µM 2.4579469189376 0.00602733459315772 no 84 0.00698669128998647 137 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2712 st079126 47.7 µM 2.45379045766655 0.00609983307229308 no 85 0.0070679663265992 117 3152970 SGTC_2066 5222451 176 µM 2.45333134800483 0.00610788822585923 no 86 0.00707699468046684 166 2281147 SGTC_2972 9093619 59.92 µM 2.44608520670798 0.00623627714310401 no 87 0.00722084329478404 126 25236256 SGTC_1103 duloxetine 36.1 µM 2.44360500085063 0.00628076787338791 no 88 0.00727066873964299 154 60835 A selective serotonin reuptake inhibitor. SGTC_1220 1838-0075 193 µM 2.43780275007123 0.00638594994259011 no 89 0.0073884173466931 110 5529645 SGTC_522 1273-0010 11.6 µM 2.43397803810499 0.00645613319659648 no 90 0.0074669505814868 133 5705015 SGTC_2831 7999036 19.48 µM 2.43319157568934 0.00647064903775377 no 91 0.00748318995929982 182 2988270 SGTC_3031 9088762 49.47 µM 2.43261306424321 0.00648134512328163 no 92 0.00749515528591401 123 205253 SGTC_2544 sphondin 68.51 µM 2.41836318789621 0.00674979521379956 no 93 0.00779525354861822 123 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2450 5739737 12.93 µM 2.4165604094943 0.00678444801200328 no 94 0.00783396307227701 119 2262825 SGTC_99 0109-0120 622.8 µM 2.41276844422871 0.0068578501303307 no 95 0.00791593705533736 113 759414 SGTC_1863 st057641 20.1 µM 2.40341852647822 0.00704184382819091 no 96 0.00812129297255994 125 3921635 SGTC_3200 9114385 49.47 µM 2.39825897196971 0.00714523097901693 no 97 0.00823660698156607 152 17018030 YLR208W SEC13 SGTC_1829 berberine 14.4 µM 2.39642152141181 0.00718237185843379 no 98 0.00827801921492224 116 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_687 k029-0044 34.9 µM 2.38757539781159 0.00736357432746432 no 99 0.00847996175005666 118 5829338 SGTC_1999 st074831 12.5 µM 2.37899651745678 0.00754313896846658 no 100 0.00867991998702167 153 17112523 SGTC_2556 citropten 84.59 µM 2.37710540400897 0.00758323679130494 no 101 0.00872455060097039 172 2775 A potential DNA crosslinker. SGTC_1861 st057647 17.4 µM 2.3714012916221 0.0077053219121656 no 102 0.0088603896794326 139 688668 SGTC_872 0588-0139 234 µM 2.36648531083044 0.0078119232049095 no 103 0.0089789434350832 166 2047100 SGTC_466 geldanamycin 89.2 µM 2.35624633083364 0.00803812574004081 no 104 0.00923033568543787 78 5288382 HSP90 inhibitor. SGTC_2669 eugenol 100 µM 2.34115770226486 0.00838196031003317 no 105 0.00961202249111395 79 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2960 9079389 5.97 µM 2.33082521085241 0.00862479988288108 no 106 0.009881289090598 155 16457355 SGTC_179 1273-0063 6.77 µM 2.31897186155224 0.00891096452135151 no 107 0.010198281047651 124 3108139 SGTC_1074 carmofur 3.8 µM 2.30769932066463 0.00919079064625338 no 108 0.0105079329481681 182 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2998 9066762 71.4286 µM 2.30511716892042 0.00925596158220997 no 109 0.0105800060934986 179 4945196 SGTC_1934 st074720 32.6 µM 2.29841921706829 0.00942689967944592 no 110 0.0107689704030635 207 17250992 SGTC_2142 5622915 118.518 µM 2.28957817241038 0.00965675509949097 no 111 0.0110228907607975 121 5322196 SGTC_515 4092-1064 102 µM 2.28615749906382 0.00974699352160425 no 112 0.0111225230807975 221 717353 SGTC_292 k038-0015 474 µM 2.27707373424284 0.00999021054566156 no 113 0.0113909114389203 124 46368540 SGTC_1397 3532-0190 20.1 µM 2.27231609116716 0.0101196973964101 no 114 0.0115337128031274 99 5322280 SGTC_904 1141-0088 396 µM 2.25630286793106 0.0105663417068537 no 115 0.0120258349558197 144 1378119 SGTC_3291 9121177 71.43 µM 2.2522558345667 0.0106819052672235 no 116 0.0121530547107205 136 17015612 SGTC_2087 5276107 200 µM 2.24969105480899 0.0107557113610942 no 117 0.0122342818766184 135 144405 SGTC_2638 epoxomicin 18 µM 2.24183857767432 0.0109844477396939 no 118 0.01248590347617 163 9915668 A protesome inhibitor. SGTC_485 niflumic acid 177 µM 2.2400398351141 0.0110374355119666 no 119 0.0125441684352498 127 4488 A COX2 inhibitor. SGTC_492 tmb-8 126 µM 2.2373676425738 0.0111165640430666 no 120 0.0126311607723792 59 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1637 st007924 17.4 µM 2.23677568006538 0.0111341597379932 no 121 0.0126505024072355 157 683336 SGTC_1076 itraconazole 331 nM 2.23019342794019 0.0113314504804456 no 122 0.012867302191499 163 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3263 9137018 49.47 µM 2.22674449932162 0.0114360334716709 no 123 0.0129821772842425 162 43844957 SGTC_2400 5203494 178.7 µM 2.22246870472336 0.0115668531705798 no 124 0.0131258233565669 154 6777674 SGTC_2581 avocatin a 64 µM 2.20988931820228 0.0119592876410134 no 125 0.0135564223784947 210 6710728 A skin care supplement. SGTC_695 3505-6186 243 µM 2.20677564738717 0.0120581882344479 no 126 0.0136648686103354 156 1819379 SGTC_440 fluspirilene 35.1 µM 2.19879707512936 0.0123148571361775 no 127 0.0139461772890529 188 3396 An atypical antipsychotic. SGTC_1402 3909-7673 35.9 µM 2.1868570947281 0.0127078017053177 no 128 0.0143764789598718 172 5328014 SGTC_529 4076-0302 30.3 µM 2.18325773582205 0.0128283650013755 no 129 0.0145084175485695 163 5816522 SGTC_199 4063-0024 41.6 µM 2.18215044601256 0.0128656529761495 no 130 0.0145492155779393 125 306215 SGTC_3217 9129673 49.47 µM 2.18006533995056 0.0129361234151602 no 131 0.0146263092597336 205 17248312 SGTC_1789 tunicamycin 25 nM 2.17548100183312 0.0130922350608829 no 132 0.0147970451341382 194 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_495 decylubiquinone 155 µM 2.16821007386464 0.0133431730397409 no 133 0.0150713533473746 199 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1060 3448-7350 82 µM 2.16707191475761 0.0133828274269245 no 134 0.0151146855186233 186 570178 SGTC_2144 5628481 200 µM 2.1622004406121 0.0135537056110088 no 135 0.0153013648034105 167 2818399 SGTC_770 0389-1121 67.2 µM 2.16080150187901 0.0136031233359177 no 136 0.0153553380085465 218 6753108 SGTC_2337 9009472 200 µM 2.16018139040565 0.0136250785607581 no 137 0.0153793151068821 227 5742383 SGTC_1191 1487-1166 10.6 µM 2.15958409337656 0.0136462549386454 no 138 0.0154024404545538 205 3955771 SGTC_1272 0839-0021 27 µM 2.15562674756829 0.013787276099579 no 139 0.0155564111208702 183 5027250 SGTC_2035 5154463 94.595 µM 2.14884812781299 0.0140317555321254 no 140 0.0158232204315212 207 2769623 SGTC_2282 7944268 200 µM 2.14688921080261 0.0141030985910442 no 141 0.0159010513831588 222 2970414 SGTC_1740 st038286 13.222 µM 2.13478090705873 0.0145510528170968 no 142 0.0163894552876486 202 716786 SGTC_905 2-aminofluorene 215 µM 2.13291696375472 0.0146210869117424 no 143 0.0164657692504371 208 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3324 9138759 60.749 µM 2.12323308808386 0.014989625953842 no 144 0.0168671622820914 178 45595710 SGTC_2765 myclobutanil 7.74 µM 2.11359169683942 0.0153644524766917 no 145 0.0172750778207842 216 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_796 1234-0020 70.7 µM 2.10983571070902 0.0155126365925169 no 146 0.0174362546796816 191 46495034 SGTC_2933 9026794 32.47 µM 2.10980821305875 0.0155137259587844 no 147 0.0174374393774183 211 17586027 SGTC_587 k089-0003 57 µM 2.1031832108104 0.0157781075836552 no 148 0.0177248786611465 91 9659696 SGTC_653 0203-0016 55.2 µM 2.102985646095 0.0157860507065674 no 149 0.0177335121234566 197 295302 SGTC_1424 4048-1941 275 µM 2.0981522609102 0.0159814488550589 no 150 0.0179458486046272 214 X1424 SGTC_2953 9074162 66.49 µM 2.09488957264684 0.0161145178185631 no 151 0.018090405005778 168 16451992 SGTC_2110 5483698 200 µM 2.08659239372742 0.016457203300432 no 152 0.018462497719739 186 2848765 YHR062C RPP1 SGTC_2284 7945075 39.21 µM 2.08577251404053 0.0164914017648273 no 153 0.0184996171497101 227 1245402 SGTC_175 3793-3120 23.7 µM 2.07846475379815 0.0167989165285167 no 154 0.0188332869875559 200 5322297 SGTC_2842 9000675 19.48 µM 2.07704698844818 0.016859141590581 no 155 0.0188986112962273 202 2989072 SGTC_729 4092-0585 94.1 µM 2.07331111960676 0.0170187220551185 no 156 0.0190716672593517 199 2169061 SGTC_2764 methyldopa 94.69 µM 2.07264447424829 0.0170473336622769 no 157 0.0191026894030595 211 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1215 3852-0577 11.2 µM 2.06022066857245 0.017588118981771 no 158 0.019688724942556 205 2884876 SGTC_1430 4049-0248 69.1 µM 2.05826900871435 0.0176743881163827 no 159 0.0197821587110661 219 22774488 SGTC_3171 9103192 49.47 µM 2.03697768054146 0.0186392196900277 no 160 0.0208261393576831 138 13018434 SGTC_1256 0570-0116 285 µM 2.03357447355763 0.0187975209448481 no 161 0.0209972588546112 205 410638 SGTC_2004 4023728 41.89 µM 2.02967764146029 0.0189801868395886 no 162 0.0211946585228136 244 360084 YDR527W RBA50 SGTC_2140 5586273 200 µM 2.02387344186243 0.0192550593034863 no 163 0.0214915875914681 154 854421 SGTC_2478 5763493 32.33 µM 2.0221845382118 0.0193356742649844 no 164 0.0215786455038754 192 1365576 YLR208W SEC13 SGTC_2779 methotrexate 400 µM 2.02191040519139 0.0193487862328242 no 165 0.0215928043125574 228 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1997 st073024 93.8 µM 2.01519921507459 0.0196721514920025 no 166 0.0219418898743368 182 686268 SGTC_3182 9108849 49.47 µM 1.9796029781305 0.0214649891080461 no 167 0.0238740790466379 246 17133045 SGTC_1795 st049545 62.3 µM 1.9779337901267 0.0215523439360398 no 168 0.0239680882051161 179 5291882 SGTC_963 1269-2853 151 µM 1.97720595001409 0.0215905284835735 no 169 0.0240091776648348 218 3668223 SGTC_2888 9058547 12.99 µM 1.97599340327659 0.0216542690623366 no 170 0.0240777621724343 167 16476514 SGTC_953 1188-0045 9.7 µM 1.97233584681285 0.0218475016698092 no 171 0.0242856400268785 256 6144426 SGTC_932 2857-0803 154 µM 1.96668497040234 0.0221489054520884 no 172 0.0246097703288467 227 674898 SGTC_462 ag-879 158 µM 1.96433249738545 0.0222754111038029 no 173 0.0247457726886306 261 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_211 3455-0679 143.504 µM 1.95924569841422 0.0225510420515483 no 174 0.025042009843257 253 748649 SGTC_2176 5809774 33.9695 µM 1.95403170089803 0.0228365440838159 no 175 0.0253487341401274 202 2870539 SGTC_1647 st011722 22.4 µM 1.95002465536014 0.0230580214742174 no 176 0.0255865902280189 207 2854783 SGTC_1645 Cervolide 78 µM 1.94872648673756 0.0231301606561969 no 177 0.0256640484642115 175 23173 A fragrance. SGTC_1126 isoteolin 1.0172 µM 1.9446108346446 0.023360124710817 no 178 0.0259109171518251 251 133323 SGTC_1557 sumaresinolic acid 42.3 µM 1.94392815996117 0.0233984549182903 no 179 0.0259520574454922 233 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_660 4031-1742 102 µM 1.94334778035653 0.0234310831618414 no 180 0.0259870760545123 278 6738706 SGTC_2120 5538279 151.968 µM 1.94155195524153 0.0235322848765126 no 181 0.0260956819795503 232 2058197 SGTC_2667 digitoxin 100 µM 1.93923147380288 0.0236635972985966 no 182 0.0262365793905603 127 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1310 1188-0297 994 nM 1.93724539345103 0.0237764753619054 no 183 0.0263576769031259 251 1588352 SGTC_2145 5634607 200 µM 1.93532081121965 0.0238862897373075 no 184 0.0264754700349014 181 308662 SGTC_692 k241-0027 77.8 µM 1.93279942278094 0.0240308019720962 no 185 0.026630455745222 224 3600480 SGTC_1303 1160-0052 261 µM 1.92546232968297 0.024455509261422 no 186 0.0270857721671018 235 3562476 SGTC_1490 4089-0339 670 nM 1.92254977647866 0.0246258405167206 no 187 0.0272683082998161 162 742542 SGTC_1248 0469-0687 58.6 µM 1.9192770917549 0.0248184194745427 no 188 0.027474637798686 252 4017482 SGTC_1939 st074455 53.6 µM 1.91603660139975 0.025010346935556 no 189 0.0276802185051767 262 1644229 SGTC_2084 5306078 60.6385 µM 1.91376109551696 0.025145862776867 no 190 0.0278253442997313 250 679340 SGTC_2376 9072922 81.32 µM 1.89998826772973 0.0259792893804825 no 191 0.0287173296470549 283 17087968 SGTC_637 1181-0519 7.26 µM 1.89806713238533 0.0260973579039682 no 192 0.0288436195877758 378 6252091 YGR060W ERG25 SGTC_320 4092-0846 5.34 µM 1.89433035066022 0.026328297358634 no 193 0.0290905874367141 242 1359356 SGTC_458 nppb 133 µM 1.88580110354772 0.0268618241437664 no 194 0.0296608810907544 211 4549 A chloride channel blocker. SGTC_3033 9090887 49.47 µM 1.88431229089062 0.0269558724253368 no 195 0.029761372931098 284 19325384 SGTC_2745 rifampicin 24.3 µM 1.88274050786663 0.0270554600455274 no 196 0.0298677714672118 128 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1171 0368-0077 21.4 µM 1.88162763016702 0.0271261570952916 no 197 0.0299432960063286 227 3239779 SGTC_1458 k015-0034 6.33 µM 1.88098806870312 0.0271668557974141 no 198 0.029986770944007 236 3598957 SGTC_1058 3448-5425 97.3 µM 1.87778021635839 0.0273717578797369 no 199 0.0302056188763105 254 7279705 SGTC_731 3966-0296 387 µM 1.87669189804567 0.0274415665311886 no 200 0.0302801668556141 249 660956 SGTC_738 1315-0003 72.4 µM 1.8730510965086 0.0276761805109286 no 201 0.0305306647285366 267 6251474 SGTC_3208 9114115 49.47 µM 1.86595305426288 0.0281383872790381 no 202 0.0310239669366976 284 650895 SGTC_2073 5212005 126 µM 1.86300352924764 0.0283323341772066 no 203 0.0312308848455032 157 691789 SGTC_1500 4488-1866 171 µM 1.86264835957697 0.028355763335026 no 204 0.0312558778721299 270 2900003 SGTC_3067 9117431 49.47 µM 1.86145682332607 0.0284344821404854 no 205 0.0313398462611434 208 17150885 SGTC_3072 9116419 49.47 µM 1.85946395529443 0.0285665472361803 no 206 0.031480701902547 239 17170162 SGTC_2275 7947463 200 µM 1.85896307748021 0.0285998199519611 no 207 0.0315161860565341 232 1225414 SGTC_176 1486-1328 72.834 µM 1.85693764401536 0.028734695963357 no 208 0.0316600130478072 321 22310231 SGTC_2958 9077254 16.72 µM 1.84419064447497 0.0295957230790434 no 209 0.0325776806614276 268 16457351 SGTC_105 0111-0055 734.78 µM 1.84201472648485 0.0297448192148629 no 210 0.0327364979009208 204 5179370 SGTC_2766 oltipraz 83.91 µM 1.83631223714221 0.030138518628695 no 211 0.033155745478957 254 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2407 paclitaxel 400 µM 1.83250626097864 0.0304036792004243 no 212 0.0334380149068032 313 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2296 7971656 126.45 µM 1.82775468892353 0.0307374289825845 no 213 0.0337931881574734 304 666570 SGTC_2126 5251174 33.877 µM 1.82079286085213 0.031231900057046 no 214 0.0343191749682928 367 790722 SGTC_1746 st038117 42 µM 1.81938236555877 0.0313328792551925 no 215 0.0344265575934674 295 2898218 SGTC_426 0988-0037 14.6 µM 1.81698885779227 0.0315048513056107 no 216 0.0346094097267923 331 5383008 SGTC_264 promethazine 12.5 mM 1.81567664484202 0.0315994636516149 no 217 0.0347099943671796 396 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_181 1447-1644 8.07 µM 1.80359830130924 0.0324814044043292 no 218 0.035647151287767 290 534600 SGTC_2391 6285546 200 µM 1.79989806231873 0.0327556184092751 no 219 0.0359383678473845 316 846083 SGTC_2385 9074692 200 µM 1.79969987883828 0.032770358902122 no 220 0.0359540201270795 322 17046906 SGTC_3335 9143315 29.6265 µM 1.78923489473681 0.0335565271356886 no 221 0.0367884970692351 274 4899691 SGTC_2390 9097792 176.6 µM 1.78828831739711 0.0336283967509537 no 222 0.0368647518556228 259 4497149 SGTC_1672 st016598 6.51 µM 1.7852071416956 0.0338632151903775 no 223 0.0371138619971082 339 4665860 YNL267W PIK1 SGTC_2474 5321570 43.32 µM 1.78240521090365 0.0340779215970058 no 224 0.0373415881834884 241 2841384 SGTC_2981 9013952 38.96 µM 1.77993490523101 0.0342681435212688 no 225 0.0375433072172912 296 2996344 SGTC_2543 pimpinellin 60.67 µM 1.7759389260074 0.0345776945737737 no 226 0.0378714920641368 289 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2696 st077691 74.316 µM 1.76568509568023 0.0353825342089587 no 227 0.0387243473156111 283 757133 SGTC_425 3825-7017 13.1 µM 1.75899595940364 0.0359158084870472 no 228 0.0392890974331454 339 3397440 SGTC_3179 9107801 49.47 µM 1.75762163937369 0.0360261839517779 no 229 0.0394059544464037 279 4818259 SGTC_1133 3473-0247 50 µM 1.75365970855238 0.0363459333364632 no 230 0.0397444166769372 353 711311 SGTC_1506 4226-2149 212 µM 1.75334831498908 0.0363711626417668 no 231 0.0397711184749516 358 991114 SGTC_2303 7774051 200 µM 1.75144202054704 0.0365259244632999 no 232 0.0399349000895766 287 2953184 SGTC_1309 pyrazolanthrone 13.4 µM 1.74746466298922 0.0368505598170738 no 233 0.0402783846885564 316 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_136 0097-0015 404.482 µM 1.74354904705596 0.0371724565756258 no 234 0.0406188773613669 337 4861337 SGTC_2290 7904846 200 µM 1.73742780320375 0.0376802751188923 no 235 0.0411558436174358 319 2962154 SGTC_1460 k062-0059 9.15 µM 1.73183848142122 0.0381488983735285 no 236 0.0416511622434882 280 1373085 SGTC_836 0330-0104 1.35 µM 1.72184965261229 0.0389982200490156 no 237 0.0425483786771743 312 46494820 SGTC_152 4469-0003 551.229 µM 1.72058557409931 0.0391067901229935 no 238 0.0426630265262881 296 697280 SGTC_480 am 92016 50 µM 1.71893618449382 0.0392488239182292 no 239 0.0428129962617421 265 2129 K+ channel blocker. SGTC_1893 st059353 36.1 µM 1.71660462329934 0.0394503174028779 no 240 0.0430257185898045 334 3112488 SGTC_1670 st016595 4.04 µM 1.71281273881075 0.0397798084782732 no 241 0.0433734978955763 312 597879 SGTC_1609 st001574 46.4 µM 1.70966430235193 0.0400550848579339 no 242 0.0436639837474402 306 3960012 SGTC_230 MPP+ 141.667 µM 1.70659324730953 0.0403250848222857 no 243 0.0439488405788904 309 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2097 5376186 200 µM 1.70156940002595 0.040769954779732 no 244 0.0444180589173074 341 742755 SGTC_1848 st056003 16.4 µM 1.69862838115296 0.0410322295260312 no 245 0.0446946127194733 324 146492 SGTC_3316 9136639 10.545 µM 1.6947983193758 0.0413758370693385 no 246 0.0450568432126011 296 4903665 SGTC_2325 6158266 200 µM 1.69007101639343 0.0418031506384132 no 247 0.0455071845285205 329 3623240 SGTC_2795 7780010 54.55 µM 1.6890126327771 0.0418993087366553 no 248 0.0456085045358896 322 953673 SGTC_2173 5763948 167 µM 1.68882915065209 0.0419159969721092 no 249 0.0456260878753395 331 2867177 SGTC_2788 5282734 71.43 µM 1.68729699372947 0.0420555613088211 no 250 0.0457731293893026 387 743706 SGTC_2642 cholecalciferol 100 µM 1.68221515184445 0.0425211615280376 no 251 0.0462635635216586 286 9821465 A vitamin D precursor, similar to steriods. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.67043884424178 0.0436161412482418 no 252 0.0474162848352501 364 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_427 1354-0053 47.3 µM 1.6688443854469 0.0437661302189978 no 253 0.0475741118735714 354 6813657 SGTC_639 0833-0042 114 µM 1.66585419751333 0.0440485356737107 no 254 0.0478712291165766 368 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_446 go6976 132 µM 1.66545941579018 0.0440859300152706 no 255 0.0479105670071882 286 3501 A protein kinase C inhibitor. SGTC_363 0455-0021 3.06 µM 1.64497146649511 0.0460619746619909 no 256 0.0499878477210026 395 4597466 SGTC_3242 9133940 49.47 µM 1.63819064079692 0.0467314348069886 no 257 0.0506909656956676 320 17248444 SGTC_1369 1866-0067 208 µM 1.63677074081644 0.0468726029409059 no 258 0.0508391907584993 411 3531355 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.63671577699791 0.046878074377484 no 259 0.050844935427779 312 279621 SGTC_715 0868-0130 184 µM 1.63670728950799 0.0468789193200943 no 260 0.0508458225632764 304 2876258 SGTC_270 tamoxifen 5.46 µM 1.6319053784076 0.0473589187150941 no 261 0.0513497104211795 392 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3331 9141060 1.957 µM 1.63079818024222 0.0474701511826954 no 262 0.0514664557826794 340 4906567 YPR165W RHO1 SGTC_2049 5262831 67.185 µM 1.62945038201197 0.0476058374271143 no 263 0.0516088552994806 350 763417 SGTC_2075 5212009 200 µM 1.61223252045672 0.0493666765571969 no 264 0.0534556755329303 304 780898 SGTC_3040 9091894 49.47 µM 1.61139115993537 0.0494540359574182 no 265 0.0535472463893491 293 25236966 SGTC_839 0122-0028 230 µM 1.60810119162019 0.0497968223088368 no 266 0.0539065091419984 436 759448 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.60138649077075 0.0505023169635584 no 267 0.0546456714926369 380 115019 SGTC_2265 7929201 200 µM 1.60078849797861 0.0505655306036739 no 268 0.054711886001654 372 1265108 SGTC_2166 5933061 31.504 µM 1.59988442536259 0.0506612195119081 no 269 0.0548121125201512 378 2877375 SGTC_2268 7933382 153.85 µM 1.59692386139307 0.0509755814630075 no 270 0.0551413400827446 444 935025 YOR257W CDC31 SGTC_3170 9103054 49.47 µM 1.59674051545516 0.0509951006521391 no 271 0.0551617802038336 331 16432970 SGTC_3065 9113888 49.47 µM 1.59344923829345 0.0513465062110928 no 272 0.055529723667196 339 16648368 SGTC_1332 1480-0653 17.5 µM 1.59051210386297 0.0516617243703287 no 273 0.0558597097536461 377 5749438 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.58356328659426 0.0524136090344287 no 274 0.0566465670816852 306 61125 An anti-inflammatory. SGTC_3338 9144300 39.5675 µM 1.57946402241593 0.0528612208441979 no 275 0.0571148312346334 389 4901274 SGTC_3351 9150312 21.596 µM 1.57691289856798 0.0531413135055686 no 276 0.0574077841003947 394 4904905 SGTC_930 2810-3379 265 µM 1.57642985984495 0.0531944794834606 no 277 0.0574633857007701 432 1015764 SGTC_643 k048-0106 28.4 µM 1.57479854144192 0.0533743433608583 no 278 0.0576514766051 362 6763920 SGTC_3269 9137823 49.47 µM 1.5674120511423 0.0541947932196526 no 279 0.0585092044519678 352 17682936 SGTC_1509 1326-1131 80 µM 1.56631568746867 0.0543174172371891 no 280 0.0586373651049911 335 768313 SGTC_1728 st035614 33.7865 µM 1.56603360604401 0.0543490024264492 no 281 0.0586703749459781 466 15945546 SGTC_982 1491-0518 27.5 µM 1.56077616974373 0.05494035063413 no 282 0.059288285986607 344 3091256 SGTC_3007 9078383 71.4286 µM 1.54905090985398 0.0562775021969001 no 283 0.0606847411641224 392 6496995 SGTC_3252 9135871 49.47 µM 1.54422233333568 0.0568355577724815 no 284 0.0612672401159643 386 17682838 SGTC_1661 st013063 9.66 µM 1.53763880612872 0.0576034503921479 no 285 0.0620684767839085 451 721395 SGTC_1651 st011928 86.1 µM 1.53582383358135 0.0578165745399193 no 286 0.0622907963203042 370 720198 SGTC_1407 3909-7909 12.3 µM 1.53319723136444 0.0581261018980698 no 287 0.0626136331183307 415 4411780 SGTC_1073 triclabendazole 3.09 µM 1.52792402604598 0.0587514433124174 no 288 0.063265701071897 471 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1697 st025554 27.742 µM 1.52666582723801 0.0589014286647569 no 289 0.0634220645238991 366 1269519 SGTC_2814 7977482 42.97 µM 1.52496300607061 0.0591048941022607 no 290 0.0636341625330234 484 6456762 SGTC_2791 5663188 71.43 µM 1.52292601413532 0.0593490124020049 no 291 0.0638886083001716 396 54690634 SGTC_253 dyclonine 31.25 µM 1.52275471358538 0.0593695774769662 no 292 0.063910041898308 461 3180 An oral anasthetic. SGTC_3012 9080433 71.4286 µM 1.52071799962608 0.0596145185808289 no 293 0.0641653098816822 414 17688859 SGTC_1695 st026914 34.495 µM 1.51858409861195 0.0598719964530246 no 294 0.0644336080969276 411 3289191 SGTC_1118 chelidonine 707.474 nM 1.51532009343545 0.0602675176200182 no 295 0.0648456810958832 429 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2859 9028643 45.46 µM 1.51407661681603 0.0604187348155188 no 296 0.0650032042499654 368 17151580 SGTC_424 splitomicin 100 mM 1.51004289240309 0.0609113139249248 no 297 0.0655162399267864 404 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_319 1348-1596 45.5 µM 1.50506791466297 0.0615231521800563 no 298 0.0661533085045536 430 5380505 SGTC_94 0334-0113 514.748 µM 1.49874018193648 0.0623082789495224 no 299 0.0669705241014277 419 6795178 SGTC_2914 7968218 45.32 µM 1.4987201870542 0.0623107721835268 no 300 0.0669731187257555 367 2977111 SGTC_3112 9123419 49.47 µM 1.49861415207706 0.0623239953677654 no 301 0.0669868795927317 456 17015854 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.49594483607667 0.0626575962491828 no 302 0.067334015522866 414 641818 YHR062C RPP1 SGTC_1481 3346-2004 36 µM 1.49019975254242 0.0633803147868723 no 303 0.0680858607214676 436 2770522 SGTC_1313 1220-0047 237 µM 1.48800041801286 0.0636586974848332 no 304 0.0683753916967838 476 3528706 SGTC_1725 st036284 20.55 µM 1.48523857561894 0.0640096264321982 no 305 0.0687403183404969 485 707914 SGTC_823 0417-1665 178 µM 1.48372035661395 0.0642031761258118 no 306 0.0689415617482675 432 3429856 SGTC_1140 3229-1848 2.98 µM 1.47886348501831 0.0648254092388547 no 307 0.0695884021360861 384 2849525 SGTC_1484 3473-2379 286 µM 1.47405682653455 0.0654458091985743 no 308 0.0702331457414089 518 671917 SGTC_2424 5537928 59.2 µM 1.47391241501445 0.0654645195364662 no 309 0.070252587303281 480 5382802 SGTC_2243 6634756 200 µM 1.47099874476293 0.0658429092348901 no 310 0.0706457281683317 374 885676 SGTC_1862 st057513 3.81 µM 1.47059807017925 0.0658950759644009 no 311 0.0706999230832148 416 5393163 SGTC_817 1391-0715 46 µM 1.46658419036883 0.0664194412543599 no 312 0.0712446016721825 411 1353946 SGTC_2939 9044578 71.43 µM 1.46462870828596 0.0666760691344685 no 313 0.0715111225414606 422 2653634 SGTC_948 3448-0295 75.3 µM 1.4628139323336 0.0669149173283545 no 314 0.0717591498533427 500 678569 SGTC_1327 1436-0082 2.18 µM 1.46106108069642 0.0671462433396311 no 315 0.0719993398405587 427 15992205 SGTC_2770 toltrazuril 17.5 µM 1.45786266556945 0.0675699351770066 no 316 0.0724392005741199 458 68591 Kills coccidiodes. SGTC_196 k015-0023 18.111 µM 1.45567198964634 0.0678613224564124 no 317 0.072741658319698 480 5211998 SGTC_2785 7756463 72.73 µM 1.4532481549556 0.0681848525951815 no 318 0.0730774331666073 444 2201551 SGTC_1785 bathophenanthroline 24 µM 1.45205000760903 0.0683452187422679 no 319 0.0732438504885925 476 72812 An iron chelator. SGTC_1062 mesoridazine 14.2 µM 1.44886750193317 0.0687725947463313 no 320 0.0736872941433322 463 4078 A neuroleptic. SGTC_1080 nisoldipine 24.4 µM 1.4481771918003 0.0688655672945423 no 321 0.0737837508197457 481 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_13 0199-0087 65 µM 1.44294592123743 0.0695732791819373 no 322 0.0745178528813361 465 4589825 SGTC_2312 7706453 155.7 µM 1.44218416575871 0.0696767986182781 no 323 0.0746252131473175 456 976098 SGTC_1366 1683-0113 21.9 µM 1.44002443423685 0.0699709419472662 no 324 0.0749302431288406 418 708623 SGTC_1149 3909-7961 23.3 µM 1.43974331523367 0.0700092989515571 no 325 0.0749700168635488 448 735261 SGTC_1708 st033234 31.827 µM 1.43869838668816 0.0701520150288614 no 326 0.0751179983199282 487 674664 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.4380334109486 0.0702429537007264 no 327 0.0752122872521657 445 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1842 st055362 61.2 µM 1.42539022463821 0.0719892700186687 no 328 0.0770222160977472 500 676032 SGTC_2944 9067346 25.62 µM 1.41069136052583 0.0740611506190875 no 329 0.0791678197621076 484 6473075 SGTC_906 1165-0455 526 µM 1.41050869960977 0.0740871811971252 no 330 0.0791947647354513 451 3252859 SGTC_2607 solasodine 47.35 µM 1.40994188319152 0.0741680013682726 no 331 0.0792784220836161 490 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1101 ebselen 5.29 µM 1.40917097847385 0.0742780297593812 no 332 0.0793923085004924 492 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1019 4262-0212 3.4 µM 1.40234159412235 0.0752582125849454 no 333 0.080406632648025 572 4677213 SGTC_2518 prenyletin 46.28 µM 1.3989219187704 0.0757527094900329 no 334 0.080918199449514 370 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2060 5238662 140 µM 1.39663681409673 0.0760845204446079 no 335 0.081261406944881 469 790130 SGTC_3178 9107506 49.47 µM 1.39261761629458 0.0766708149445217 no 336 0.081867726507516 478 8897194 SGTC_2915 7971052 15.16 µM 1.38990472875699 0.0770684914042855 no 337 0.0822789047445598 332 5741558 SGTC_3133 9127736 49.47 µM 1.38599762702626 0.0776439770593542 no 338 0.0828738140420456 492 27243420 SGTC_17 0960-0276 49.807 µM 1.37754758096042 0.0788997532691884 no 339 0.0841715073376978 533 6821114 SGTC_2065 5221596 34.26 µM 1.37607977733477 0.0791194458443045 no 340 0.0843984678445868 495 788581 SGTC_1436 4092-1007 8.32 µM 1.37578947431686 0.0791629515806546 no 341 0.0844434105600648 467 2881121 SGTC_1776 st049249 45.9 µM 1.36924079467439 0.0801491772627136 no 342 0.0854620089928272 523 1822314 SGTC_3236 9132701 49.47 µM 1.36904011938288 0.0801795447926755 no 343 0.08549336722461 492 24282524 SGTC_2088 5278280 127.392 µM 1.36898424421609 0.0801880017450414 no 344 0.0855021000095578 538 791502 SGTC_1664 st014217 9.02 µM 1.36815207878364 0.0803140334520917 no 345 0.085632239039982 511 3982782 SGTC_2012 4023501 200 µM 1.36749427653447 0.0804137636855313 no 346 0.0857352150154153 470 3477460 SGTC_1827 berberine 7.24 µM 1.36704078732214 0.0804825722290657 no 347 0.0858062606708022 456 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2477 5967686 25.23 µM 1.358760740164 0.0817467481252537 no 348 0.0871112088548061 502 776118 SGTC_819 1013-0258 27.7 µM 1.3563625962909 0.0821156713746444 no 349 0.0874919139923101 514 5753198 SGTC_414 piperonyl butoxide 100 µM 1.35610625039745 0.0821551809388807 no 350 0.0875326822280469 493 5794 A potent inhibitor of cytochrome P450. SGTC_757 1066-0008 322 µM 1.35294376501199 0.0826437807798121 no 351 0.0880367981917035 539 6842497 SGTC_672 1441-0018 53.7 µM 1.34667998557904 0.0836179771803436 no 352 0.0890416604819029 483 251141 SGTC_1226 3909-7979 35.4 µM 1.34497258580807 0.083885017198099 no 353 0.089317043868581 578 6615510 SGTC_811 0416-0114 265 µM 1.33609323193541 0.0852840965109517 no 354 0.0907594009500178 502 6612453 SGTC_1650 st011916 45.8 µM 1.33499950065638 0.0854576330071358 no 355 0.0909382549407602 479 242528 SGTC_1825 st052143 62.6 µM 1.3320701370078 0.0859237220610203 no 356 0.0914185711624599 462 674173 SGTC_2903 5923464 63.88 µM 1.33065324118544 0.0861498448400334 no 357 0.0916515676258695 494 2876576 SGTC_3168 9103419 49.47 µM 1.32917680740964 0.0863859425956182 no 358 0.0918948224125039 412 16649256 SGTC_2175 5807670 165.306 µM 1.32912378292193 0.0863944307767105 no 359 0.0919035675256993 502 241186 SGTC_2089 5281248 129.67 µM 1.3224117732453 0.0874739348674563 no 360 0.0930155352818797 534 2737878 SGTC_1755 st041960 45.185 µM 1.3218218020357 0.0875693001423599 no 361 0.0931137483041248 513 2257073 SGTC_1873 rapamycin 2 nM 1.32063873689191 0.0877607692030773 no 362 0.0933109250920335 573 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2705 st078069 42.8 µM 1.31935256649106 0.0879692790933824 no 363 0.0935256358172986 497 1530061 SGTC_2823 7987624 58.44 µM 1.31812305425392 0.0881689488930849 no 364 0.0937312290507152 564 2239440 SGTC_974 1326-0144 138 µM 1.31755676304567 0.088261026762352 no 365 0.0938260337437214 557 5411856 SGTC_154 3389-1638 511.116 µM 1.31537661332468 0.0886161840810865 no 366 0.0941916806658714 470 5238686 SGTC_1289 0976-0073 69.1 µM 1.31450786353145 0.0887580040015657 no 367 0.0943376767942481 558 3391136 SGTC_3197 9113331 49.47 µM 1.31414441319989 0.0888173859312962 no 368 0.0943988052523226 545 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1683 st010134 710 nM 1.31294208985798 0.0890140369909737 no 369 0.0946012313066096 539 3818134 SGTC_1388 3346-4487 254 µM 1.31278331344925 0.0890400305420889 no 370 0.0946279871851844 588 3345614 SGTC_3237 9133362 49.47 µM 1.31271155002349 0.0890517809060848 no 371 0.0946400820807902 512 43845137 SGTC_166 k072-0058 166.424 µM 1.31117338494962 0.0893039137687779 no 372 0.0948995960398813 536 5846229 SGTC_1204 4049-0315 18.3 µM 1.31050000552798 0.0894144597359649 no 373 0.0950133711756191 526 588402 SGTC_261 5-fluorouridine 15.376 µM 1.30856144232529 0.0897332740624712 no 374 0.0953414745028349 544 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_501 nsc-95397 161 µM 1.3072177345011 0.0899547544010749 no 375 0.0955693870606969 515 262093 SGTC_1949 st076024 69.1 µM 1.30630502451345 0.0901054258519781 no 376 0.0957244245605671 543 2921930 SGTC_2384 9036245 200 µM 1.30555749432597 0.0902289687907973 no 377 0.0958515415634781 554 6462766 SGTC_1445 4239-0156 97.7 µM 1.30239947667294 0.090752277259487 no 378 0.0963899306980903 616 4008346 SGTC_404 fumagillin 50 µM 1.30091270901482 0.0909994247789791 no 379 0.0966441677035274 572 12015870 A methionine aminopeptidase binder. SGTC_2177 5811945 192 µM 1.29980161747523 0.0911844488376546 no 380 0.0968344855035271 537 5343475 SGTC_2428 5615643 7.78 µM 1.29961319383162 0.0912158536530272 no 381 0.0968667876812216 528 2253075 SGTC_1044 1222-0021 1.78 µM 1.29797262760055 0.0914896279552066 no 382 0.0971483705410746 547 4306703 SGTC_3000 9075062 71.4286 µM 1.29726843436858 0.0916073288944015 no 383 0.0972694206708459 520 17057871 SGTC_753 1322-0200 289 µM 1.29714205016644 0.0916284649942278 no 384 0.0972911577004111 542 5403907 SGTC_1398 3558-0053 112 µM 1.29551318268048 0.0919011951816106 no 385 0.0975716283703226 467 4532369 SGTC_1086 cerivastatin 2.18 µM 1.29277207719689 0.0923615098748731 no 386 0.098044950259539 521 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2742 clothiapine 36.27 µM 1.29115536214904 0.0926338040600422 no 387 0.0983249050239706 498 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2801 7907800 81.82 µM 1.28861896873917 0.0930621902939123 no 388 0.0987652927914565 583 6620925 SGTC_2269 7935389 174.42 µM 1.28665775743514 0.0933944331917158 no 389 0.099106801393876 546 97605 SGTC_390 dec-rvkr-cmk 16.7 µM 1.28379477104887 0.0938810150451857 no 390 0.0996068868341072 584 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1969 st069479 40.1 µM 1.28373188503703 0.0938917238641221 no 391 0.0996178919591524 490 3895485 SGTC_3095 9117207 49.47 µM 1.28279587500985 0.0940512230062704 no 392 0.0997817998430941 491 17015229 SGTC_2676 harmalol 100 µM 1.28211568832855 0.0941672543863355 no 393 0.0999010331761254 581 5459187 A monoamine oxidase inhibitor SGTC_506 n9-isopropylolomoucine 153 µM 1.28023330284981 0.0944889163740551 no 394 0.10023154837329 545 6610355 SGTC_246 cycloheximide 667 µM 1.27994880296905 0.0945376020938874 no 395 0.100281571115765 485 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2302 7771753 200 µM 1.27838264254119 0.0948059461887248 no 396 0.100557270579892 596 2203047 SGTC_1938 st074717 56.4 µM 1.2715770781174 0.0959785237146829 no 397 0.101761712625583 505 17250979 SGTC_589 1227-0070 34.1 µM 1.26726487883445 0.0967270014506068 no 398 0.102530297084276 571 2841384 SGTC_1720 st037298 9.481 µM 1.26534185143041 0.0970621641192818 no 399 0.102874405045766 530 597396 SGTC_2292 7671323 168.05 µM 1.26501601650302 0.0971190379386204 no 400 0.102932793227244 569 937504 SGTC_1487 3970-0795 2.82 µM 1.26240341168528 0.0975759472597241 no 401 0.103401831107311 601 3765103 SGTC_1524 corynanthine 62.1 µM 1.26092895281543 0.0978345050680712 no 402 0.103667222867923 537 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1291 0993-0025 5.79 µM 1.25693347777074 0.0985376662262897 no 403 0.104388862373447 585 4353356 SGTC_3137 9097352 49.47 µM 1.25143576845691 0.0995112426953036 no 404 0.105387767144693 632 44120435 SGTC_1370 2001-0092 44.6 µM 1.25096448692693 0.0995950268499102 no 405 0.105473717188018 667 790957 SGTC_3150 9097574 49.47 µM 1.24684299757188 0.100329940332576 no 406 0.106227535561672 549 17217476 SGTC_2127 5253358 187.912 µM 1.24631705554952 0.100424006430872 no 407 0.106324009371898 521 20612 SGTC_1281 0884-0031 11.8 µM 1.24621813970921 0.100441704973602 no 408 0.106342160621288 608 1548255 SGTC_3346 9158254 43.5805 µM 1.24576032318113 0.10052364956093 no 409 0.106426199992952 584 17639500 SGTC_2357 9067248 200 µM 1.24300760254813 0.101017387535509 no 410 0.106932515972121 542 9150235 SGTC_1340 1486-1359 257 µM 1.24091764804388 0.101393428216047 no 411 0.107318086281249 605 4309068 SGTC_2701 st077767 14.721 µM 1.24062710516768 0.101445785551505 no 412 0.107371767037641 643 5721188 SGTC_1503 4585-0012 61.3 µM 1.23834169795703 0.101858314621075 no 413 0.107794694335017 557 2922052 SGTC_362 0310-0100 9.03 µM 1.23808495150351 0.101904735005643 no 414 0.107842281562034 572 790235 SGTC_1995 st072814 61.1 µM 1.23741965757311 0.102025093406591 no 415 0.107965662303886 575 5769371 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.23581706969524 0.102315442376624 no 416 0.108263284254812 622 6728940 SGTC_247 mechlorethamine 29.705 µM 1.23322965952062 0.102785484172038 no 417 0.108745046326966 536 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_524 r073-0010 27.8 µM 1.22652653452152 0.104010501359815 no 418 0.110000298133519 592 2772106 SGTC_2473 5854593 8.94 µM 1.2228253643079 0.104691421547433 no 419 0.110697831593699 568 2872951 SGTC_2583 asiatic acid 100 µM 1.2182285345799 0.105541607611215 no 420 0.111568569513734 574 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2692 st077426 47.7 µM 1.21797917879496 0.10558786844833 no 421 0.11161594257299 621 25238571 SGTC_3255 9139072 49.47 µM 1.21734910144273 0.105704826617781 no 422 0.111735709920344 614 17646060 SGTC_2627 acetyl isogambogic acid 100 µM 1.21611222676354 0.105934693941424 no 423 0.111971086759324 576 6857789 A caspase activator and apoptosis inducer. SGTC_2201 6605497 169.863 µM 1.2147749047449 0.106183635133274 no 424 0.11222597734348 579 670741 SGTC_2847 9005661 71.43 µM 1.21463961215331 0.106208843235887 no 425 0.112251786888449 467 2991449 SGTC_1853 st056710 91.2 µM 1.21422918824103 0.106285341039547 no 426 0.11233010873476 622 269167 SGTC_2777 climbazole 1.536 µM 1.21405185578345 0.106318405865377 no 427 0.112363961447155 645 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2157 5649910 96.377 µM 1.21041855056158 0.106997496012375 no 428 0.113059163602007 629 2858091 SGTC_1646 st011709 75.6 µM 1.20766339702863 0.107514535356967 no 429 0.113588381378835 571 5757843 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.20691886462573 0.107654564784382 no 430 0.113731695935908 700 91467 include heat shock SGTC_2198 6589944 200 µM 1.20305652034098 0.108383092056367 no 431 0.114477224675327 512 5290268 SGTC_3348 9149464 3.537 µM 1.20024164548241 0.108916272723349 no 432 0.115022752841983 624 1951442 SGTC_3353 9151644 39.2805 µM 1.19929474594513 0.1090960532225 no 433 0.115206678680313 637 4909158 SGTC_1353 1498-1206 8.11 µM 1.19784021814647 0.109372628417919 no 434 0.115489613369487 692 6756808 SGTC_1927 st060202 13.8 µM 1.19412788078972 0.110080803252459 no 435 0.116213974279853 613 688887 SGTC_745 0469-0705 296 µM 1.19203228223854 0.110482014537576 no 436 0.116624293728759 711 3486736 SGTC_2045 5106652 78.05 µM 1.19111091863135 0.110658744915826 no 437 0.116805022028412 605 673349 SGTC_1732 st034308 51.822 µM 1.19047704441701 0.110780448406806 no 438 0.11692947362467 602 830119 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.18933020954961 0.111000883724304 no 439 0.117154876037557 555 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_956 1185-0240 191 µM 1.18925614919538 0.111015129797826 no 440 0.117169442658757 619 1416193 SGTC_854 0422-0053 192 µM 1.18822155939018 0.111214277966635 no 441 0.117373065966663 611 3596728 SGTC_1270 0831-1170 17.3 µM 1.18765276381583 0.111323874318936 no 442 0.117485120450983 695 6764716 SGTC_2906 7926292 26.41 µM 1.18739642200207 0.111373291893966 no 443 0.1175356453317 623 2966319 SGTC_283 0987-0079 11.7 µM 1.18637407391418 0.11157053634236 no 444 0.117737302787835 662 411556 SGTC_2499 avocadenofuran 51.48 µM 1.18561994067044 0.111716193460549 no 445 0.117886211893991 622 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2146 5545642 200 µM 1.18558081668569 0.111723753775145 no 446 0.117893940844134 639 825326 SGTC_1223 0764-0573 147 µM 1.18481052948195 0.111872678534677 no 447 0.118046184239008 667 1609797 SGTC_493 zm226600 134 µM 1.18461517415954 0.111910470438609 no 448 0.118084817332884 644 5240098 A potassium channel opener. YCR052W RSC6 SGTC_978 1416-0512 87.4 µM 1.18306554953912 0.112210572078432 no 449 0.118391584947715 680 6814003 SGTC_2307 7538926 6.34 µM 1.18277436769126 0.112267026739063 no 450 0.118449290859913 661 96582 SGTC_1164 k060-0068 93.7 µM 1.1827237408104 0.112276844406062 no 451 0.118459326035521 686 5963676 SGTC_1122 capsaicin 818.572 nM 1.18261742101696 0.11229746415231 no 452 0.118480402523114 649 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_888 0916-0002 6.97 µM 1.18093015077185 0.112625056991651 no 453 0.118815236271697 655 2802138 YIL048W NEO1 SGTC_628 1636-0253 16 µM 1.17673441228711 0.113442640124677 no 454 0.119650764071968 677 4456143 SGTC_2748 diazoxide 86.69 µM 1.17611870446662 0.113562972405516 no 455 0.11977372225016 582 3019 A potassium channel activatior. SGTC_2161 5662504 8.5105 µM 1.17534020210436 0.113715251059037 no 456 0.119929318362805 613 2859334 SGTC_286 k060-0067 22.9 µM 1.17449359540314 0.113881016379398 no 457 0.120098687887091 618 5985051 SGTC_353 1988-1175 58.3 µM 1.17377314623449 0.114022215650728 no 458 0.120242951425043 594 2788357 SGTC_1959 st077091 55.8 µM 1.17337079269366 0.114101126305465 no 459 0.120323572254208 654 821356 YKL052C ASK1 SGTC_1475 4092-1048 11.7 µM 1.17294161576884 0.114185340502658 no 460 0.12040960973083 692 2881759 SGTC_813 k007-0158 173 µM 1.17163365012154 0.114442265884153 no 461 0.120672085984161 724 6523916 SGTC_934 2950-0684 338 µM 1.17047755333717 0.114669701878589 no 462 0.120904421065448 677 1121253 SGTC_1322 1348-1070 12 µM 1.1686826401409 0.115023447619933 no 463 0.121265759371714 606 6758089 SGTC_1457 k015-0032 57.3 µM 1.16560953444154 0.115630903046257 no 464 0.121886175589912 649 4302660 SGTC_1751 st044839 27.194 µM 1.16407405620897 0.115935270682727 no 465 0.122197000716917 639 5291326 SGTC_1696 st025591 34.7925 µM 1.1634301143522 0.116063084142565 no 466 0.122327518626096 665 2787147 SGTC_1982 st072467 71.9 µM 1.16314496258888 0.116119714723657 no 467 0.122385346104108 707 3163533 SGTC_2017 5132927 60.65 µM 1.16245268496421 0.116257281297407 no 468 0.12252581667239 640 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3318 9139014 38.6185 µM 1.16187805452806 0.116371557307376 no 469 0.122642501254239 626 16643984 SGTC_3102 9121669 49.47 µM 1.16157170873264 0.116432512455061 no 470 0.122704739745081 606 41905072 SGTC_1550 gossypolone 36.6 µM 1.15817627956534 0.117109634906016 no 471 0.123396053123349 669 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2602 kawain 100 µM 1.15816312127269 0.1171122643715 no 472 0.12339873746397 723 5369129 SGTC_633 0437-0093 97.7 µM 1.15752200913415 0.117240430620247 no 473 0.12352957628011 639 2831118 SGTC_1764 st044502 93.5 µM 1.15498138399881 0.117749309924905 no 474 0.124049024956029 667 8407 SGTC_976 1348-1067 47.6 µM 1.15326939987089 0.118093095357828 no 475 0.124399912955518 726 5310671 YGL099W LSG1 SGTC_3204 9114183 49.47 µM 1.14794653111219 0.11916651945072 no 476 0.125495318771065 627 17027248 SGTC_3344 9148862 3.898 µM 1.14763860817204 0.1192288260864 no 477 0.12555889229758 663 4905352 SGTC_1365 1672-3266 55.4 µM 1.14710778935736 0.119336288542806 no 478 0.125668537485669 706 6415873 SGTC_1464 k208-0027 110 µM 1.14641366633176 0.119476914481213 no 479 0.125812015326612 684 X1464 SGTC_1038 k292-0204 154 µM 1.14557499963229 0.119646980177637 no 480 0.125985523262553 625 4454212 SGTC_1092 toremifene 6.32 µM 1.14370548347573 0.120026696896536 no 481 0.126372899266293 714 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2262 9014885 67.46 µM 1.14205203242154 0.120363235825819 no 482 0.126716196109379 583 6457424 SGTC_45 0kpi-0036 14.9 µM 1.14125430711919 0.120525840140332 no 483 0.126882055403038 621 2795021 SGTC_1903 st060211 78.3 µM 1.14086854164263 0.12060452809988 no 484 0.126962316135644 710 688960 SGTC_70 0141-0289 43.283 µM 1.13707968543147 0.121379296833276 no 485 0.127752487698634 865 352408 SGTC_776 4476-4378 112 µM 1.13536806780129 0.121730444072241 no 486 0.128110566593313 642 2892008 SGTC_93 0109-0045 59.227 µM 1.13525328394104 0.121754018090141 no 487 0.128134604864316 777 88733 SGTC_208 k072-0098 12.366 µM 1.1341770095457 0.121975216648999 no 488 0.128360152858546 762 5948901 SGTC_2999 9069765 71.4286 µM 1.12878035481709 0.123088605823532 no 489 0.129495250948033 699 2097066 SGTC_1419 3993-2473 62.6 µM 1.1251054212984 0.123850850365185 no 490 0.130272182150231 705 704026 SGTC_2928 9011484 9.79 µM 1.12408158287702 0.124063799347536 no 491 0.13048920881116 628 2994751 SGTC_1441 4106-0040 13 µM 1.11923702551565 0.125074896414833 no 492 0.131519516828144 686 2904180 SGTC_2843 9000894 45.46 µM 1.11405931167772 0.126161872981384 no 493 0.132626871277059 546 2242070 SGTC_602 3130-1533 38.1 µM 1.11240254071871 0.126511071514488 no 494 0.132982556355492 750 720941 SGTC_10 0279-0212 42.575 µM 1.11188214810617 0.126620893778233 no 495 0.133094412623207 792 39851 YBR002C RER2 SGTC_1295 1013-0063 9.78 µM 1.11143996483923 0.126714263116686 no 496 0.133189508987997 707 6826038 SGTC_138 0850-0259 40.9225 µM 1.1112813424992 0.126747768745045 no 497 0.133223633855568 802 6813004 SGTC_1048 3161-0300 24.5 µM 1.10901496777021 0.127227166494543 no 498 0.133711862510611 711 2165101 SGTC_232 clozapine 119 µM 1.1059887616259 0.127869253161019 no 499 0.134365691857206 686 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1440 4100-1550 40 µM 1.10398297332402 0.128296071054671 no 500 0.134800261863388 693 742806 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.10375529122394 0.128344582677938 no 501 0.134849651879203 756 16486 A toxic proline analog. SGTC_1203 3992-3522 103 µM 1.10259464863501 0.1285920756544 no 502 0.135101617602233 738 5322312 SGTC_2778 tioconazole 65.09 nM 1.1000789333646 0.129129657893895 no 503 0.135648865887587 707 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1901 st060216 58.6 µM 1.09791383725772 0.129593562326677 no 504 0.136121057570276 706 688792 SGTC_1252 0493-0875 34.8 µM 1.09771262939279 0.129636732695796 no 505 0.136164996602733 680 3960963 SGTC_2034 5197015 53.07 µM 1.09630515107504 0.12993899426125 no 506 0.136472627963669 717 780676 SGTC_951 1171-0579 82.7 µM 1.09578605028157 0.130050596275531 no 507 0.13658620729657 777 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1716 st033144 30.6155 µM 1.09414462560967 0.130403924337447 no 508 0.1369457765474 736 674617 SGTC_1119 parthenolide 318.541 nM 1.09367129903373 0.130505934395078 no 509 0.137049583166784 781 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1996 st072960 66.8 µM 1.09199203671318 0.130868289578408 no 510 0.137418300694567 751 1719405 SGTC_3320 9137005 35.139 µM 1.0910178545462 0.131078819297597 no 511 0.137632513141896 681 4908713 SGTC_1715 st032160 10.2275 µM 1.09092813245353 0.131098220826456 no 512 0.137652253545198 685 5289825 SGTC_3247 9135149 49.47 µM 1.09001906864492 0.131294908900071 no 513 0.13785237219202 658 8934436 YOR116C RPO31 SGTC_2010 4012422 159 µM 1.08953050094437 0.131400701182772 no 514 0.137960006019315 719 952393 SGTC_2540 epiandrosterone 100 µM 1.08764556773998 0.131809407724596 no 515 0.138375803037385 852 441302 A steroid. SGTC_157 1348-1695 65.819 µM 1.08676870698211 0.131999834384898 no 516 0.138569520360994 755 5380510 SGTC_321 4534-3890 65.3 µM 1.08650906300983 0.132056257304542 no 517 0.138626916715406 715 699746 SGTC_820 1582-0060 59.9 µM 1.08465965827066 0.132458630349757 no 518 0.139036210784851 727 3848840 SGTC_1014 4130-3005 69.3 µM 1.08294702410833 0.132831999068461 no 519 0.139415968917477 729 743608 SGTC_2729 fluphenazine 10.66 µM 1.08182949880056 0.133076019400173 no 520 0.139664148169245 720 3372 An atypical antipsychotic. SGTC_3227 9130768 49.47 µM 1.08048744854292 0.133369474038917 no 521 0.139962586532577 751 17720899 SGTC_2363 9053361 176 µM 1.08027932674972 0.133415022089677 no 522 0.140008906391498 725 6469797 YMR079W SEC14 SGTC_630 4356-0227 183 µM 1.07493175660959 0.134589023681511 no 523 0.141202641437112 700 779312 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.07018575235014 0.135636880598872 no 524 0.142267853098521 746 688667 SGTC_1290 0986-0249 10.2 µM 1.06757065062087 0.136216643552639 no 525 0.142857114258271 672 53329 SGTC_2485 5633444 17.78 µM 1.06606029338033 0.136552258264098 no 526 0.143198193673443 711 5724239 SGTC_742 0kpi-0133 140 µM 1.06479860190217 0.136833050420258 no 527 0.143483538984464 777 2728852 SGTC_1932 st074806 40.9 µM 1.06145184887502 0.137579788459211 no 528 0.144242302241417 782 17251235 SGTC_1137 ixabepilone 100 µM 1.06084670591761 0.137715106249575 no 529 0.144379786207172 778 154225 A novel microtubule stabilizer. SGTC_2758 dehydroepiandrosterone 69.35 µM 1.05303076392013 0.139471015031622 no 530 0.146163446351464 767 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1335 1486-0900 202 µM 1.05210089021755 0.139680927144418 no 531 0.14637663188452 766 X1335 SGTC_2462 5162487 171.77 µM 1.05169591796586 0.139772413749002 no 532 0.146469542219834 779 2259986 SGTC_1794 st048918 76.9 µM 1.05133477003806 0.13985403442744 no 533 0.146552431592121 672 672303 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.0495530295669 0.140257188049831 no 534 0.146961831007613 734 6710655 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.04911233679016 0.140357025046825 no 535 0.147063209393237 776 3256 An antibiotic and ribosome inhibitor. SGTC_3167 9103034 49.47 µM 1.04821673124701 0.140560069177692 no 536 0.147269381830286 694 5127859 SGTC_364 0083-0097 67.7 µM 1.0472036778226 0.140789980310556 no 537 0.147502824699636 747 5207356 SGTC_2278 7948257 134.34 µM 1.04500301688055 0.141290296175405 no 538 0.148010787593631 765 1247028 SGTC_369 0957-0393 4.5 µM 1.04367834207455 0.141592038742378 no 539 0.148317116696896 701 6997992 SGTC_1173 0443-0020 122 µM 1.04342069810456 0.141650777145942 no 540 0.148376745715041 744 5331295 SGTC_1868 st057644 42.7 µM 1.04204575570656 0.141964519489892 no 541 0.148695232919328 807 688665 SGTC_343 4130-2827 29.8 µM 1.04126588492711 0.142142683883595 no 542 0.14887608261643 781 1118244 SGTC_994 3910-0338 138 µM 1.04114242887056 0.142170901748941 no 543 0.148904725175584 786 3479481 SGTC_1320 1313-0481 95.3 µM 1.03949724743328 0.142547296274259 no 544 0.149286768778779 805 6813365 YLR208W SEC13 SGTC_1819 st053448 58.6 µM 1.03753951293708 0.142996075949218 no 545 0.149742245441402 762 2857616 SGTC_47 0149-0135 24.25 µM 1.03694198428204 0.143133239901027 no 546 0.149881447915789 730 5239155 SGTC_449 xestospongin c 11.1929 µM 1.03385004821651 0.143844419870595 no 547 0.150603135092949 795 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2174 5790901 200 µM 1.03189890138872 0.14429443029773 no 548 0.151059740343172 741 786020 SGTC_3106 9121286 49.47 µM 1.03032776035253 0.144657485608746 no 549 0.15142808590776 715 15943471 SGTC_671 0560-0003 407 µM 1.0295741493002 0.144831846317338 no 550 0.151604977730143 750 3238678 SGTC_3305 9127027 53.8275 µM 1.02915635451907 0.1449285711824 no 551 0.151703104029125 771 41905295 SGTC_1792 st045773 43.6 µM 1.02333543845189 0.146280711989912 no 552 0.15307463672562 759 2919270 SGTC_167 3672-0051 66.205 µM 1.02122334090587 0.146773419100211 no 553 0.153574318143051 707 3237971 SGTC_708 3448-5400 146 µM 1.02100585487545 0.146824217084275 no 554 0.153625832398613 775 3462195 SGTC_1643 st009866 20.2 µM 1.02070461476469 0.146894596900166 no 555 0.153697203740786 783 3156273 YOR207C RET1 SGTC_924 2046-0044 21.3 µM 1.01922563273343 0.14724046505193 no 556 0.154047930114375 798 3623589 SGTC_67 0335-0847 266 µM 1.01880479202198 0.147338980666765 no 557 0.154147825137919 891 4552207 YOR254C SEC63 SGTC_2982 9019404 25.97 µM 1.0183178121579 0.147453034076603 no 558 0.154263473089869 646 22333232 SGTC_3181 9108277 49.47 µM 1.01698361686639 0.147765813060503 no 559 0.154580611591541 762 17097298 SGTC_3081 9117243 49.47 µM 1.0142516608701 0.148407658187692 no 560 0.155231341712934 783 45595589 SGTC_792 4534-1957 155 µM 1.01183870102627 0.148976106937513 no 561 0.155807591155945 784 1717904 SGTC_3270 9137563 49.47 µM 1.00891200107727 0.149667533092043 no 562 0.156508419559667 746 17015724 SGTC_2106 5357045 167.29 µM 1.00881568225261 0.149690324526255 no 563 0.156531519317183 806 668842 SGTC_2412 st077135 33.4 µM 1.00647835634267 0.150244103956123 no 564 0.157092758964934 787 13258915 SGTC_629 3448-6466 76.7 µM 1.00589149678361 0.150383361966524 no 565 0.157233883531746 810 573744 SGTC_829 1635-0120 117 µM 1.00475969293531 0.15065217455733 no 566 0.157506288457357 838 285054 SGTC_2569 tetrandrine 100 µM 1.00374831481696 0.150892655629122 no 567 0.157749971303376 710 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_226 1,3-diallylurea 8.28947 mM 1.00090543830662 0.151569990275434 no 568 0.158436263554424 760 74537 YKL182W FAS1 SGTC_3153 9100258 49.47 µM 1.00035795846486 0.151700662809999 no 569 0.158568653964738 723 25236848 SGTC_1762 st045503 25.4615 µM 1.00030617597239 0.151713026134196 no 570 0.158581179651205 806 4645554 SGTC_3085 9117376 49.47 µM 0.999876645869888 0.151815604367822 no 571 0.158685103860635 786 16480349 SGTC_2759 disulfiram 3.38 µM 0.998856061041645 0.152059520135498 no 572 0.158932211990984 748 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1805 st050013 60.3 µM 0.995866155868181 0.152775593118487 no 573 0.159657590663794 780 4037144 SGTC_275 trichlorophene 5.69 µM 0.995739923028019 0.152805874615385 no 574 0.159688263509531 915 62616 SGTC_3273 9137859 49.47 µM 0.995157896986541 0.152945546025008 no 575 0.159829737712882 808 2377234 SGTC_780 0109-0199 192 µM 0.99502106027187 0.152978395632965 no 576 0.159863010780277 849 610414 SGTC_2103 5378138 10 µM 0.994130558774822 0.153192287499456 no 577 0.160079654840177 893 244142 SGTC_1146 3579-1023 7 µM 0.992917865548284 0.153483885999845 no 578 0.160374991302938 891 X1146 SGTC_2119 5528445 120.635 µM 0.992888043923979 0.153491061395377 no 579 0.160382258474111 807 791935 SGTC_1676 st018489 23.4 µM 0.991984389067699 0.15370859559641 no 580 0.160602570344615 802 3696235 SGTC_421 streptovitacin 30 mM 0.984349063960015 0.155554769916954 no 581 0.162471956632946 848 91467 include heat shock SGTC_289 k017-0060 526 µM 0.984133639598474 0.15560706949039 no 582 0.162524904394945 780 5512909 SGTC_2399 5884133 200 µM 0.981868950527994 0.156157580374942 no 583 0.163082207039193 778 722445 SGTC_116 0155-0182 31.788 µM 0.976895245393078 0.15737110973042 no 584 0.164310507948883 908 771486 SGTC_1063 disulfiram 1.84 µM 0.976473486935089 0.157474298512434 no 585 0.164414940149887 801 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_841 0251-0215 91.2 µM 0.974370309837261 0.157989532196359 no 586 0.164936352872502 866 3888614 SGTC_2129 girgensonine 121.053 µM 0.972685435092094 0.158403088269807 no 587 0.165354833126575 874 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1608 st001473 40.5 µM 0.970546385262878 0.158929144744775 no 588 0.165887107833275 793 7292267 SGTC_1343 1487-0095 224 µM 0.969502223926448 0.159186350677661 no 589 0.166147335576132 840 4560101 YGL055W OLE1 SGTC_1139 k015-0024 46.9 µM 0.9671789191477 0.159759622843919 no 590 0.166727299352003 845 2766652 SGTC_824 1304-0008 100 µM 0.966444178825285 0.159941199756116 no 591 0.166910983246156 841 768245 SGTC_2747 doxorubicin 7.63 µM 0.965633982535546 0.160141580572233 no 592 0.167113682275252 655 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2403 6032726 181.2 µM 0.9641438142921 0.160510562985337 no 593 0.167486914374044 798 2881040 SGTC_3349 9149703 23.001 µM 0.963953184995891 0.160557804980743 no 594 0.167534698686601 831 4910494 SGTC_1565 sinapyl alcohol 95.1 µM 0.962000572621565 0.161042226805724 no 595 0.168024658147499 803 5280507 A phenol propionate derived from cinnamic acid. SGTC_3253 9135987 49.47 µM 0.960375045805076 0.161446229050574 no 596 0.168433246302654 793 4182430 SGTC_3222 9128301 49.47 µM 0.953929571799489 0.163054662379839 no 597 0.170059646704563 865 4911358 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.953347329803276 0.16320046894066 no 598 0.170207059160492 867 229346 A bile salt which induces apoptosis. SGTC_3060 1327-0027 12.5 µM 0.952948660923923 0.163300353494371 no 599 0.170308041648091 813 16000455 YPR107C YTH1 SGTC_3343 9148379 18.9835 µM 0.952770626502575 0.163344971980964 no 600 0.170353150009496 873 1955036 SGTC_2405 ticlatone 3.52 µM 0.952062924929612 0.163522412464942 no 601 0.17053253514783 864 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1020 4335-0961 93.3 µM 0.950390219519873 0.163942303646644 no 602 0.170957005881492 800 669075 SGTC_3035 9091303 49.47 µM 0.949451037095202 0.164178368492022 no 603 0.171195631672997 863 25237002 SGTC_3226 9131256 49.47 µM 0.947346238897157 0.164708212755306 no 604 0.171731188141065 771 17178073 SGTC_2199 6590217 200 µM 0.94660584182276 0.164894857205295 no 605 0.171919833016802 795 703109 SGTC_2130 NSC 7 2.4545 µM 0.944700479037183 0.165375803868414 no 606 0.172405906206641 895 21448 SGTC_2665 lovastatin 100 µM 0.943366288394071 0.165713116483474 no 607 0.172746790147882 839 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1750 st081859 2.357 µM 0.943021971439711 0.165800239514275 no 608 0.172834832369894 992 5291695 SGTC_2740 felodipine 17.08 µM 0.942553337414776 0.165918866246496 no 609 0.17295470854289 794 3333 L-type calcium channel blocker SGTC_453 enantio-paf c16 10 µM 0.939909843971415 0.166589048773389 no 610 0.173631903751747 937 13871343 A lipid and platelet activating factor SGTC_2819 7996655 46.38 µM 0.939792934836677 0.166618728045511 no 611 0.173661891777384 760 6456960 SGTC_1435 4092-0789 56.7 µM 0.937256526184267 0.167263476419294 no 612 0.174313309788995 882 2248285 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.935272435766974 0.167768946415313 no 613 0.174823958406872 861 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1690 st023502 41.2 µM 0.934895733855358 0.167865026571694 no 614 0.174921017939875 849 24207482 SGTC_64 000l-0018 272.079 µM 0.933023280753558 0.168343132857949 no 615 0.175403974125625 915 6811119 SGTC_600 1495-0418 41.6 µM 0.932826820287374 0.168393347172114 no 616 0.175454695535796 847 5377768 SGTC_3287 9117173 37.0625 µM 0.931246473111436 0.168797626353145 no 617 0.175863041648903 851 2789709 SGTC_3087 9117406 49.47 µM 0.931014391425152 0.168857049198318 no 618 0.175923059913827 835 42546093 SGTC_1767 st044992 70.3 µM 0.930527450402697 0.168981770619261 no 619 0.176049029087525 857 9600693 SGTC_2702 st077768 96.8 µM 0.929653272700237 0.169205824365652 no 620 0.17627531766994 778 6484119 SGTC_106 0092-0003 11.579 µM 0.929013102057819 0.16937002249097 no 621 0.176441148164156 814 1072148 SGTC_312 4092-0653 6.84 µM 0.927213339266492 0.169832193476705 no 622 0.176907889176079 946 1148278 SGTC_1373 2887-0003 58.5 µM 0.926825360597438 0.169931930508747 no 623 0.177008607665295 835 776948 SGTC_3050 9093513 49.47 µM 0.926113543407406 0.170115013794428 no 624 0.177193488182583 891 25236664 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.925349139191292 0.170311763460057 no 625 0.177392162906284 847 4330530 SGTC_2178 5812956 200 µM 0.924206647478637 0.17060610053721 no 626 0.17768936764343 885 5403383 SGTC_668 1682-0499 62.6 µM 0.92247354558026 0.171053216242022 no 627 0.17814081152338 924 682214 SGTC_959 1222-0044 107 µM 0.921912544287603 0.171198107046078 no 628 0.178287097678272 903 6083612 SGTC_2192 5915882 198.485 µM 0.920998881137104 0.171434248389873 no 629 0.178525505586208 862 2876149 SGTC_1306 1185-0270 9.02 µM 0.919303050396613 0.171873096816406 no 630 0.178968541377894 921 1548076 SGTC_2862 9027634 71.43 µM 0.917647028986839 0.172302335009239 no 631 0.179401844057593 803 5012562 SGTC_885 0865-0106 16.8 µM 0.917072237473917 0.172451479835119 no 632 0.179552393944707 886 2793380 SGTC_340 k038-0059 454 µM 0.916405387397529 0.172624614830492 no 633 0.179727155357168 905 23733424 SGTC_2143 5623677 140.463 µM 0.915263512521804 0.172921338283838 no 634 0.180026654605098 873 5375313 SGTC_112 phenothiazine 287.218 µM 0.915174138998092 0.172944576268699 no 635 0.180050109359019 936 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1328 1441-0025 69.2 µM 0.915144693418308 0.172952232841401 no 636 0.180057837334274 843 4562601 SGTC_2194 5927483 104.545 µM 0.913296850058536 0.173433149431831 no 637 0.180543219290827 959 760979 SGTC_9 0092-0002 10.449 µM 0.912884733905498 0.173540522064079 no 638 0.18065158365627 885 759368 SGTC_1504 k297-0033 30 µM 0.909714437682193 0.174367924145018 no 639 0.181486564043816 770 4388117 SGTC_341 1486-1430 230 µM 0.909619963714033 0.174392618896055 no 640 0.181511483243702 870 2054753 YPL210C SRP72 SGTC_1977 st070720 65.3 µM 0.907620288454348 0.174915839399445 no 641 0.182039435706553 849 682188 SGTC_386 1509-0011 3.07 µM 0.906570658756508 0.175190876140962 no 642 0.182316941850078 957 3107280 SGTC_2011 4012611 177 µM 0.901982756298093 0.176396271348668 no 643 0.183533013937158 907 2049887 SGTC_1153 4055-0057 267 µM 0.901691937341138 0.176472855634678 no 644 0.18361026858642 922 882706 SGTC_1496 4469-0713 57.4 µM 0.901533566219436 0.176514569941804 no 645 0.18365234763001 895 746691 SGTC_1469 k284-2957 126 µM 0.896017573282299 0.177971349992742 no 646 0.185121688834662 925 23884841 SGTC_794 k038-0031 316 µM 0.895111850404681 0.17821127505872 no 647 0.185363649885956 965 6624242 SGTC_1917 st066507 28.5 µM 0.885584157540916 0.180747490533525 no 648 0.18792082581052 927 3156428 SGTC_516 3992-2719 87.3 µM 0.88531817155257 0.180818617585586 no 649 0.187992525987488 939 5350887 YDR037W KRS1 SGTC_3294 9122953 26.2835 µM 0.884154229909172 0.181130072408571 no 650 0.188306481053748 978 16459826 SGTC_2445 5742597 35.57 µM 0.882694149178773 0.181521244870231 no 651 0.188700772089456 884 1774255 SGTC_2671 danthron 100 µM 0.882359496221875 0.181610976686498 no 652 0.188791215894099 916 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_647 0140-0236 81 µM 0.882155343789259 0.181665730512626 no 653 0.188846403551051 1010 990837 SGTC_2648 atorvastatin 78.68 µM 0.879025454223744 0.182506461798396 no 654 0.189693737297012 926 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_158 k038-0087 26.446 µM 0.878537479099327 0.182637757257343 no 655 0.189826053887194 969 X158 SGTC_2815 7968870 71.43 µM 0.878425380384025 0.182667927066859 no 656 0.189856457958537 940 2977326 YHR190W ERG9 SGTC_883 0850-0245 24.6 µM 0.877429634187633 0.182936054872979 no 657 0.190126661492773 960 6823229 YPR165W RHO1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.876415350688443 0.183209426645797 no 658 0.190402138084395 895 689007 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.876162027188922 0.183277742659177 no 659 0.190470978283193 938 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1822 st052468 42 µM 0.875178473497396 0.183543136921253 no 660 0.190738402036775 939 2873678 SGTC_141 0443-0274 32.331 µM 0.874566869665224 0.183708287920858 no 661 0.19090481045331 1059 1627241 SGTC_1981 st071826 47 µM 0.874540824044446 0.183715323058212 no 662 0.190911899060662 882 11838600 SGTC_1098 clofazimine 15.1 µM 0.871152576970326 0.184631947396054 no 663 0.191835424781704 965 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3246 9135460 32.98 µM 0.870535363748038 0.184799228107961 no 664 0.192003951010112 880 41446951 SGTC_680 0417-1641 114 µM 0.868988498406939 0.185218882278044 no 665 0.192426710880578 881 2835990 SGTC_2760 etidronate 98.04 µM 0.867916946355256 0.185509933845876 no 666 0.192719900563516 930 3305 A chelator and antioxidant. SGTC_198 3454-2873 16.191 µM 0.866468365877219 0.185903843633101 no 667 0.193116683459237 936 710957 SGTC_1666 st014829 29 µM 0.865426025450408 0.186187605961592 no 668 0.193402500833915 967 3858230 SGTC_1483 3453-0561 55.9 µM 0.864016036723715 0.186571882187704 no 669 0.193789540507378 965 4546991 SGTC_202 3594-0513 34.79 µM 0.863709428897567 0.1866555095922 no 670 0.19387376632922 943 708429 SGTC_1590 st077108 57.8 µM 0.862734312754755 0.186921627136774 no 671 0.194141781086185 954 5489485 SGTC_2360 9040895 200 µM 0.86269952957652 0.186931124098395 no 672 0.194151345555407 890 4914414 SGTC_601 0986-0029 62.9 µM 0.860354969893605 0.187571954834584 no 673 0.194796700005902 967 24747981 SGTC_66 0109-0187 42.4 µM 0.860104409563346 0.187640519855397 no 674 0.19486574536297 868 759417 SGTC_2690 usnic acid 100 µM 0.859560800501141 0.18778932994159 no 675 0.195015595508077 1004 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_345 1362-0200 395 µM 0.859326716579129 0.187853431613371 no 676 0.195080144168936 924 1419823 SGTC_2726 cimetidine 79.27 µM 0.858656595522285 0.18803701263383 no 677 0.195265001899866 976 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3173 9105693 49.47 µM 0.855744475272264 0.18883607947399 no 678 0.196069566850435 1001 17096658 SGTC_599 1935-0052 86.5 µM 0.854928179127066 0.189060440755537 no 679 0.196295454681917 1006 9557311 SGTC_1259 0671-0132 43 µM 0.852320505070325 0.189778266607051 no 680 0.197018114117841 914 X1259 SGTC_41 0478-0632 82.643 µM 0.852161318105795 0.189822140912917 no 681 0.197062281368087 1028 3750424 SGTC_272 doxorubicin 8.13 µM 0.851582285710902 0.189981783490796 no 682 0.197222987447886 1027 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_943 3253-1379 105 µM 0.850323032133197 0.190329251776268 no 683 0.197572757400616 940 668464 SGTC_908 3448-7491 47.7 µM 0.849274694279459 0.190618819223856 no 684 0.197864229297516 1013 1203031 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.849154830665847 0.190651944663148 no 685 0.197897571807315 932 5379071 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.849033140554475 0.190685578486576 no 686 0.197931425866567 903 521171 SGTC_1400 3771-8998 51.5 µM 0.846087944410796 0.191500708964086 no 687 0.198751842765631 937 670767 SGTC_467 ro 31-8220 72.8 µM 0.84307091677609 0.192337929846512 no 688 0.199594391537117 967 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1942 st076330 65.2 µM 0.842397884930085 0.192525000144211 no 689 0.199782638262998 1023 24208414 SGTC_344 k064-0035 6.43 µM 0.840899429827268 0.192941897479753 no 690 0.200202138937245 943 5088750 SGTC_2414 st077232 92.9 µM 0.840359799574352 0.193092167313073 no 691 0.200353340919965 910 729801 SGTC_2854 9024559 71.43 µM 0.838845587861701 0.193514208440044 no 692 0.2007779824515 966 3163529 SGTC_946 3434-1334 87.4 µM 0.838520434659754 0.193604908479987 no 693 0.200869237957527 959 4047976 SGTC_3233 9132340 49.47 µM 0.838271533396613 0.193674355896201 no 694 0.200939109876512 991 17682950 SGTC_236 1509-0011 5.31 µM 0.836477901777446 0.194175256679528 no 695 0.201443051733835 1128 3107280 SGTC_16 erodoxin 22.806 µM 0.836059389599483 0.194292246445192 no 696 0.20156074653338 1029 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1721 st082152 9.2685 µM 0.83285770805712 0.195188655279305 no 697 0.202462491948181 973 5296051 SGTC_849 0386-0493 241 µM 0.830484116329482 0.195854834582944 no 698 0.20313256231042 971 726119 SGTC_1261 0712-0010 12.7 µM 0.830152756351018 0.195947944687277 no 699 0.203226211188151 1027 2840123 SGTC_410 α-linolenic acid 100 µM 0.829445072002682 0.196146889516497 no 700 0.203426303035907 1014 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1213 1315-0166 115 µM 0.827127057961929 0.196799388832162 no 701 0.204082524660948 880 768401 SGTC_1240 0356-0016 42.1 µM 0.826904597224587 0.196862078504388 no 702 0.204145568762193 963 4305613 SGTC_2204 7233102 200 µM 0.824533130218056 0.197531111612266 no 703 0.204818349584541 953 2172480 SGTC_528 3492-0019 172 µM 0.824196280435996 0.197626254309356 no 704 0.20491402008129 1096 2869262 SGTC_3083 9117465 49.47 µM 0.82418104612202 0.197630557872241 no 705 0.204918347487663 1050 16420915 SGTC_726 3448-4391 34.2 µM 0.823537701231498 0.197812348981524 no 706 0.20510114339775 1047 1356692 SGTC_2507 purpurin 79.67 µM 0.820647170354549 0.198630377412998 no 707 0.205923635455312 1038 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3221 9128209 49.47 µM 0.818941597492792 0.199114014992737 no 708 0.206409867677726 978 16460723 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.81624708395117 0.199879523822891 no 709 0.207179416252595 1103 6708561 SGTC_2335 9018011 154.17 µM 0.815924546025124 0.199971275018084 no 710 0.207271646133512 1054 6458208 SGTC_2139 5578692 56.4705 µM 0.814894220106601 0.200264537709419 no 711 0.207566430956887 996 650991 YMR113W FOL3 SGTC_3030 9087619 49.47 µM 0.814619294793565 0.200342833631357 no 712 0.207645131231962 1039 25236973 SGTC_525 k781-2675 26.7 µM 0.814429395801007 0.200396925662224 no 713 0.207699502117834 1065 3651118 YDL195W SEC31 SGTC_1053 3366-3204 134 µM 0.81377358129448 0.200583799471178 no 714 0.207887336161861 1035 3632071 YPR165W RHO1 SGTC_1578 josamycin 24.2 µM 0.813711574582513 0.200601473645903 no 715 0.207905100902181 939 5282165 A P450 substrate. SGTC_1632 st005650 90 µM 0.81138365948016 0.201265690685048 no 716 0.20857269003604 994 2759605 SGTC_124 0136-0217 7.121 µM 0.810163365697717 0.201614399574202 no 717 0.208923144757422 1170 3976905 SGTC_2196 6573537 42.6665 µM 0.810117182507904 0.201627603900938 no 718 0.208936414861745 1036 2903087 SGTC_2872 9044037 25.97 µM 0.806695393613629 0.202607374765999 no 719 0.209920999333697 1047 6465195 SGTC_876 0720-0963 56.8 µM 0.805168668203111 0.203045443054865 no 720 0.210361177108845 1058 765861 SGTC_2279 7948423 32.93 µM 0.803894245985859 0.203411549896582 no 721 0.210729026724723 1017 1247112 SGTC_248 streptozotocin 5.23457 mM 0.803375614709222 0.203560651233971 no 722 0.210878832570354 1077 5300 DNA alkylating agent. SGTC_1021 4476-0760 85.3 µM 0.80133271731547 0.204148597678853 no 723 0.211469527488531 1039 746768 SGTC_1638 st008370 60.6 µM 0.800023567789392 0.204525902475726 no 724 0.211848571258255 1049 24207134 SGTC_3339 9145883 14.936 µM 0.79634588276492 0.205588051472407 no 725 0.212915511878076 978 2030670 SGTC_3111 9122088 49.47 µM 0.795706974689194 0.205772907238016 no 726 0.213101185982561 951 16876704 SGTC_3292 9120825 59.784 µM 0.794674955472892 0.206071710394823 no 727 0.213401302167053 1068 24824900 SGTC_221 trifluoperazine 10.304 µM 0.792438295216659 0.206720178747119 no 728 0.214052578747037 1134 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1813 st051246 8.6015 µM 0.791825986870476 0.206897913948354 no 729 0.214231073782053 1017 5291959 SGTC_2620 irigenin 100 µM 0.790532419042425 0.207273696084619 no 730 0.214608448489572 1060 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_825 1988-2224 89.6 µM 0.789498071021909 0.207574464915123 no 731 0.214910478378274 1021 1180859 SGTC_801 0866-0028 10.1 µM 0.788493552823244 0.207866806507592 no 732 0.215204034124286 1083 6849771 SGTC_1461 k072-0203 53.8 µM 0.787923019703349 0.208032955072385 no 733 0.215370867661502 1019 5418714 SGTC_2853 9015042 58.44 µM 0.787670855901716 0.208106414265012 no 734 0.215444628529055 1036 6457456 SGTC_3166 9102297 49.47 µM 0.787583796125558 0.208131779671234 no 735 0.215470097936638 1040 25237072 SGTC_1878 temozolomide 1 mM 0.784710991813102 0.208969812083258 no 736 0.21631151833731 1036 5394 DNA alkylating agent. SGTC_1889 st059080 5.18 µM 0.783698882567406 0.209265529620586 no 737 0.216608409184365 1101 176925 Isolated from Daphnopsis sellowiana. SGTC_217 ketoconazole 989 nM 0.782278885434898 0.209680838583701 no 738 0.217025346450386 1037 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_775 4577-0580 57.3 µM 0.781857841301621 0.209804075173358 no 739 0.217149061837132 1075 2006902 SGTC_2985 9022375 71.43 µM 0.781623081776242 0.209872806083211 no 740 0.21721805891026 1121 4939335 SGTC_1325 1431-0015 227 µM 0.779069856495302 0.210621172085095 no 741 0.217969282785079 1020 1103340 SGTC_373 0844-0104 25.9 µM 0.774220565952582 0.21204683205613 no 742 0.219400184192213 1125 5375804 SGTC_1102 cgs 12066b 26.1 µM 0.773481298619899 0.212264666507406 no 743 0.219618796183623 1027 6438352 A 5-HT1B full agonist. SGTC_3001 9076041 71.4286 µM 0.772952160250292 0.212420664089425 no 744 0.219775346798068 1081 16004211 SGTC_856 0433-0016 11.3 µM 0.772687796588296 0.2124986273758 no 745 0.219853585291429 1079 3911780 SGTC_135 0933-0004 26.348 µM 0.771768671541427 0.212769815894725 no 746 0.22012572495713 1014 21230617 YGL099W LSG1 SGTC_2951 9072950 58.06 µM 0.770173252127883 0.213241024988177 no 747 0.220598564097863 1141 16488155 SGTC_1321 1326-2144 215 µM 0.768872967503203 0.213625515355838 no 748 0.220984363284161 1087 3513030 SGTC_441 propafenone 146 µM 0.768210217530784 0.213821643885238 no 749 0.221181152103981 1088 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3142 9086498 49.47 µM 0.766479120261781 0.214334424297396 no 750 0.221695635478548 1038 25236367 SGTC_1438 4092-1045 4 µM 0.764539413378347 0.214909847268112 no 751 0.222272929284534 1117 1351342 SGTC_1375 2910-0797 186 µM 0.761955597542171 0.21567774010484 no 752 0.223043252791021 1073 742508 SGTC_3240 9133527 49.47 µM 0.761022460332241 0.215955452762071 no 753 0.223321826011273 1060 17617455 SGTC_2078 5212016 200 µM 0.760948084595489 0.215977596771165 no 754 0.22334403821697 1052 1899708 SGTC_2457 5731572 11.68 µM 0.760815243469747 0.216017151048515 no 755 0.223383714154011 1139 2865357 SGTC_2434 5670830 169.91 µM 0.759180387254218 0.216504283229103 no 756 0.223872328352515 1059 1549830 SGTC_1001 4048-4355 44.4 µM 0.759092766369648 0.216530409240107 no 757 0.223898532997208 1077 21824233 SGTC_1037 k284-1091 78.7 µM 0.757820435362587 0.216909987011451 no 758 0.224279243467661 1083 3334711 SGTC_2349 9023730 187.07 µM 0.756483102584005 0.217309371231527 no 759 0.224679799827364 1091 4126287 SGTC_111 0083-0039 52.457 µM 0.756478187239483 0.217310839944497 no 760 0.224681272813656 1025 759313 SGTC_173 1273-0061 2.693 µM 0.755067805981377 0.217732500915633 no 761 0.225104149393348 1094 2847414 YPL266W DIM1 SGTC_1865 st057639 52.2 µM 0.754105218798214 0.218020555924966 no 762 0.225393021972933 1125 688818 SGTC_3285 9112818 20.8695 µM 0.752709094995286 0.218438737288603 no 763 0.225812371691824 1165 17017947 YPR165W RHO1 SGTC_354 2783-3500 4.88 µM 0.751445877514383 0.218817506950934 no 764 0.226192180681151 1094 6740761 SGTC_2755 lomerizine 42.69 µM 0.748151975025845 0.219806943246454 no 765 0.227184247399583 1136 3949 A calcium channel blocker. SGTC_1379 2144-0755 36.5 µM 0.747893422555787 0.219884716878514 no 766 0.227262222623872 1167 5392327 SGTC_2821 7996764 71.43 µM 0.747887607132352 0.219886466363065 no 767 0.227263976634506 1191 2987135 SGTC_35 0133-0054 64.071 µM 0.746036990365271 0.220443602805335 no 768 0.227822535111095 1090 99677 SGTC_397 arbidol 50 µM 0.742441082041117 0.22152847718459 no 769 0.228910068273178 1146 131410 A RNA synthesis inhibitor. SGTC_2443 5493264 126.67 µM 0.742076675748649 0.22163858747853 no 770 0.229020440306006 1118 5340055 SGTC_73 0327-0325 16.231 µM 0.741453981259471 0.221826815412281 no 771 0.229209112214031 1167 53298 SGTC_596 1155-0152 116 µM 0.741385837679706 0.221847419377723 no 772 0.229229764513589 1139 280313 SGTC_3118 9124250 49.47 µM 0.739996121494574 0.222267853833526 no 773 0.229651173863462 1021 1504786 SGTC_1896 st058441 89 µM 0.737824347148854 0.22292579587393 no 774 0.23031059803949 1063 688759 SGTC_1286 0929-0070 131 µM 0.737617233891331 0.222988599015441 no 775 0.230373539888278 1155 1420408 SGTC_1787 fluconazole 80 µM 0.737507185247021 0.223021973265331 no 776 0.23040698765264 1074 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_732 3970-1727 52.7 µM 0.737319158116209 0.223079002489327 no 777 0.230464142181857 1128 1275699 SGTC_1497 4476-2978 41.3 µM 0.737187537475432 0.223118928386819 no 778 0.23050415556867 1169 1528379 SGTC_867 0518-0118 155 µM 0.736743932494023 0.223253521793359 no 779 0.230639042475572 1171 6848158 SGTC_1142 3253-1408 9.78 µM 0.73636164901956 0.223369546812473 no 780 0.230755318730798 1129 256655 SGTC_2024 5144227 134 µM 0.736329440477248 0.223379323839212 no 781 0.230765116853366 1131 3475211 SGTC_451 chloral hydrate 100 µM 0.735666080222244 0.223580743538722 no 782 0.230966968563675 1190 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_747 3448-8087 38.7 µM 0.732791618642577 0.224454724568152 no 783 0.23184276699699 1155 5168703 SGTC_190 3970-0790 3.722 µM 0.732083111372267 0.224670443902494 no 784 0.232058920654233 1122 2832352 SGTC_303 1348-1668 34.2 µM 0.730739498702315 0.225079856668291 no 785 0.23246914224164 1141 5380509 SGTC_2575 plumbagin 510 nM 0.730364221146579 0.225194283124467 no 786 0.232583791134764 1100 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3128 9127691 49.47 µM 0.730238810581728 0.225232529597156 no 787 0.23262211160362 1043 41316314 SGTC_278 4092-0821 23.9 µM 0.729063352116422 0.225591188085604 no 788 0.232981455415458 1141 877900 SGTC_2472 5377652 49.4 µM 0.728118489579632 0.225879720792586 no 789 0.233270528209117 1152 1610903 SGTC_1410 3909-8106 77.9 µM 0.727819584521324 0.225971040872839 no 790 0.233362017140623 1163 1039210 SGTC_86 0417-1630 471.922 µM 0.727549528316925 0.226053565130724 no 791 0.233444693124581 1205 3634867 SGTC_317 4495-0002 170 µM 0.725304749568062 0.226740187581929 no 792 0.234132546305965 1113 15991618 SGTC_1249 0481-0015 10.2 µM 0.724158742545081 0.227091176117609 no 793 0.234484142174213 1127 4227577 SGTC_2116 5511452 16.8835 µM 0.724128241739292 0.227100521807862 no 794 0.234493503834639 1136 870744 SGTC_2172 5754775 163.918 µM 0.723730045160507 0.227222552308442 no 795 0.234615741907634 1095 2263357 SGTC_1192 1488-0095 21.4 µM 0.722716239541765 0.22753340784193 no 796 0.234927118179371 1124 915875 SGTC_2022 5136654 200 µM 0.722094473426976 0.227724173691755 no 797 0.23511819789692 1132 1713771 SGTC_1380 2291-0730 164 µM 0.721903989342212 0.227782634671526 no 798 0.235176754195922 1160 2999191 SGTC_1492 4158-0558 28.5 µM 0.720595485697273 0.228184452372877 no 799 0.235579216061386 1146 3967268 SGTC_384 k007-0144 5.16 µM 0.720182544083955 0.228311341919892 no 800 0.235706305046062 1158 6824886 SGTC_2083 5306046 65.942 µM 0.719212149753841 0.228609682727266 no 801 0.236005107249368 1172 539837 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.717874908177008 0.229021166617989 no 802 0.23641721023192 1121 688803 SGTC_2055 5235184 200 µM 0.716359241933226 0.229488055711774 no 803 0.236884777560532 1146 2836034 SGTC_237 nikkomycin 200 µM 0.714515589395698 0.230056696704983 no 804 0.237454209921956 1185 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_925 2064-1272 59.6 µM 0.714286031113116 0.230127554924792 no 805 0.237525164090755 1127 6815817 SGTC_2059 5238311 157 µM 0.712932217757244 0.230545687479446 no 806 0.237943850844364 1176 703021 SGTC_2459 5811157 9.22 µM 0.712023482879726 0.230826593130307 no 807 0.238225117309355 1161 2870684 YBR192W RIM2 SGTC_1181 1222-0449 220 µM 0.711430034541124 0.231010141388358 no 808 0.238408896343573 1206 658318 SGTC_2634 4'-methoxyflavone 100 µM 0.711297394422237 0.231051176926581 no 809 0.238449982937521 1139 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3076 9116187 49.47 µM 0.710620073512768 0.231260786511168 no 810 0.238659850247587 1126 27241210 SGTC_1953 st076800 12.1 µM 0.710509721005647 0.231294947198656 no 811 0.238694052451439 1140 297591 SGTC_2291 7917025 104.35 µM 0.7102678525536 0.231369829765182 no 812 0.238769025548488 1144 2964612 SGTC_3061 glucosamine 200 µM 0.707424321155175 0.23225120132443 no 813 0.239651413594406 1137 91431 and experimental redox chemotherapeutic SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.707149959512732 0.232336340261119 no 814 0.239736645940847 1202 94937 An inhibitor of serotonin biosynthesis. SGTC_2276 7947513 42.08 µM 0.70663251353359 0.232496959513688 no 815 0.239897439127235 1092 2105100 SGTC_2989 9073649 71.4286 µM 0.705889483348432 0.232727709811886 no 816 0.240128434072024 1182 21367202 SGTC_2820 7989630 71.43 µM 0.704686940834 0.233101432607648 no 817 0.240502540027928 1079 2984098 SGTC_1837 st055472 66.5 µM 0.704326523283932 0.233213507029257 no 818 0.240614726208416 1236 676091 SGTC_2899 9053889 58.44 µM 0.702952142802124 0.233641154861469 no 819 0.241042787171024 1154 6470052 SGTC_736 0958-0254 92.6 µM 0.702234230228807 0.233864710997091 no 820 0.241266550888068 1211 6812352 SGTC_3010 9080089 71.4286 µM 0.698616225499721 0.234993150354106 no 821 0.242395950453091 1190 17027233 SGTC_2879 9041815 71.43 µM 0.696838090516416 0.235548843289968 no 822 0.242952062689258 1142 4942971 SGTC_2707 st078556 66.6 µM 0.695157219407748 0.236074805740323 no 823 0.243478389584381 1157 17250899 SGTC_1968 st069590 43.6 µM 0.694982658612041 0.23612946473379 no 824 0.243533084646676 1157 6384066 SGTC_3195 9113082 49.47 µM 0.691630796049465 0.237180360884715 no 825 0.244584608388348 1166 17018038 SGTC_11 0438-0307 1.3 µM 0.690631049611668 0.23749430415171 no 826 0.24489871490501 1201 4011476 SGTC_3017 9080681 49.47 µM 0.690118460144377 0.237655357391727 no 827 0.245059847577131 1188 16451914 SGTC_310 1273-0058 1.06 µM 0.690039771075136 0.237680086437888 no 828 0.24508458856084 1227 2734232 SGTC_1502 4534-4282 27.7 µM 0.689973280330884 0.237700983104823 no 829 0.245105495261592 1182 3278949 SGTC_1359 1582-0056 520 nM 0.689715737132388 0.237781933122195 no 830 0.245186483683854 1227 3661189 SGTC_1147 3809-1045 12.3 µM 0.689047526031499 0.237992033234916 no 831 0.245396680031559 1159 325925 SGTC_2966 9084041 48.03 µM 0.687675507517348 0.238423744530075 no 832 0.245828573492273 1138 17741380 SGTC_901 1112-0062 60.1 µM 0.687593481490035 0.238449567935795 no 833 0.245854407131038 1223 1908457 SGTC_3096 9117468 49.47 µM 0.686792854331864 0.238701701505648 no 834 0.246106636683652 1117 41316311 SGTC_3116 9124943 49.47 µM 0.686257655170059 0.238870327784683 no 835 0.24627532317991 1134 41905195 YPL160W CDC60 SGTC_1411 3909-8223 150 µM 0.685881160933922 0.238988989607427 no 836 0.246394025468917 1220 X1411 SGTC_2200 6600604 21.907 µM 0.685577660188079 0.239084669115023 no 837 0.246489736458015 1181 2904777 SGTC_547 1120-0019 610 nM 0.682748444276731 0.23997759433835 no 838 0.2473829061947 1179 3676939 SGTC_691 1548-0686 185 µM 0.681236779667842 0.240455433257458 no 839 0.247860839487093 1193 46495133 SGTC_2721 ifenprodil 61.44 µM 0.680896420718799 0.240563092538249 no 840 0.247968516529655 1224 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1358 1509-0022 2.48 µM 0.680617877620347 0.240651218309068 no 841 0.248056655882449 1238 3258434 SGTC_1658 st012944 20 µM 0.679093455952317 0.241133827618829 no 842 0.248539324310683 1170 24207260 SGTC_2845 9003024 42.97 µM 0.678740049533324 0.241245785934263 no 843 0.248651292656943 1263 2990173 SGTC_2242 6630449 61.2675 µM 0.677085313864744 0.241770377885775 no 844 0.249175913165996 1211 691249 YDR170C SEC7 SGTC_612 0302-0167 22.4 µM 0.676025978774543 0.242106537942812 no 845 0.249512075569532 1251 235821 SGTC_679 0422-0091 41.4 µM 0.675549881010364 0.242257701114228 no 846 0.249663235741879 1242 627384 YHR062C RPP1 SGTC_2619 obliquin 87.91 µM 0.675350577397263 0.242320996089579 no 847 0.249726528715127 1211 6708593 A bioactive alkalod. YER133W GLC7 SGTC_511 blebbistatin 171 µM 0.675014607309064 0.242427713978983 no 848 0.249833242231907 1273 3476986 A myosin inhibitor. SGTC_1165 k072-0275 30.3 µM 0.674490759476595 0.242594160338377 no 849 0.249999679274407 1249 6153523 YGL055W OLE1 SGTC_1130 3454-2858 15.9 µM 0.673902248293088 0.242781226489305 no 850 0.250186731325446 1210 715628 YIL048W NEO1 SGTC_806 3966-4455 5.86 µM 0.672721451684113 0.24315679383582 no 851 0.250562258783838 1165 714982 SGTC_2188 6126565 140.678 µM 0.672688508706445 0.243167276270197 no 852 0.250572739883354 1192 874518 SGTC_2957 9076800 11.52 µM 0.671325992818134 0.243601041906554 no 853 0.251006439748304 1183 16459615 SGTC_2984 9022109 38.96 µM 0.670460869558556 0.243876676161649 no 854 0.251282021533373 1275 6459207 SGTC_2866 9034245 58.44 µM 0.670377681957509 0.243903189173683 no 855 0.251308529061551 1222 6462273 SGTC_2246 7293507 91.5585 µM 0.66860197122678 0.244469502924519 no 856 0.251874707399783 1265 887656 SGTC_210 3551-0445 56.827 µM 0.668477051547658 0.244509369250474 no 857 0.251914562878969 1279 2865180 YOR207C RET1 SGTC_3286 9117135 37.221 µM 0.668201038199947 0.244597467372777 no 858 0.25200263641933 1199 3438150 SGTC_5 0352-0601 109.883 µM 0.667775868205824 0.244733206854755 no 859 0.252138336376462 1165 762456 SGTC_44 0929-0055 61.211 µM 0.66743156294654 0.244843159228741 no 860 0.252248255268538 1204 1379590 SGTC_1689 st020265 53.493 µM 0.666653574173858 0.245091704411793 no 861 0.25249671993589 1241 5758320 YPR016C TIF6 SGTC_452 diindolylmethane 8 µM 0.666035859446113 0.245289143224115 no 862 0.252694090019314 1218 3071 Inhibits expression of several cancer promoting factors. SGTC_2717 st081029 62.2815 µM 0.664888929752404 0.245655960503088 no 863 0.253060768414467 1223 5292846 SGTC_2625 euphol 100 µM 0.664692020350349 0.245718966753381 no 864 0.253123749346406 1237 6708538 A triterpene alcohol. SGTC_245 methotrexate 289.6 µM 0.664456022585952 0.245794491765092 no 865 0.253199243444524 1253 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_338 4055-0136 114 µM 0.66271680610253 0.246351467367529 no 866 0.253755972076524 1209 2900563 SGTC_607 4491-0986 66.8 µM 0.661172679938033 0.246846532616686 no 867 0.254250789785267 1272 698981 YDR232W HEM1 SGTC_419 nsc-638432 893 µM 0.659101572156365 0.247511389729574 no 868 0.25491527309227 1253 368090 SGTC_1920 st075728 45.7 µM 0.658683481344355 0.247645719215798 no 869 0.255049521308224 1299 3400306 SGTC_3248 9135562 49.47 µM 0.657520449833784 0.248019597362259 no 870 0.255423163107547 1281 17650701 SGTC_3296 9122258 64.045 µM 0.6573304263778 0.248080712552894 no 871 0.255484238245733 1258 4730474 SGTC_2704 st078022 71.1 µM 0.657275498589667 0.248098379880429 no 872 0.255501893920601 1279 54697681 SGTC_2946 9065502 71.43 µM 0.655983097699964 0.24851426963839 no 873 0.255917499769278 1099 16489101 SGTC_2369 9071472 200 µM 0.655700798795447 0.248605161772765 no 874 0.256008327404236 1293 17296037 SGTC_861 0443-0273 110 µM 0.655261808867303 0.248746539085975 no 875 0.256149602646798 1268 6149169 SGTC_1991 st073000 8.92 µM 0.654614994905866 0.24895492440082 no 876 0.256357833641423 1328 4301969 YIL048W NEO1 SGTC_1970 st070122 35.8 µM 0.652763588672123 0.249551908730457 no 877 0.25695435037589 1293 102928 SGTC_1806 st050005 60.3 µM 0.652292332093774 0.249703986350448 no 878 0.257106302848229 1234 5194765 SGTC_2921 7974240 10.71 µM 0.651610786271876 0.249924012734232 no 879 0.257326143840715 1285 2979074 YDR527W RBA50 SGTC_2894 9048625 32.47 µM 0.6495543085477 0.250588537498738 no 880 0.257990077673686 1336 4092861 SGTC_1233 0325-0408 14.2 µM 0.646317674195394 0.251636307889235 no 881 0.259036821992909 1308 12874 SGTC_2375 9072683 200 µM 0.644351470319609 0.25227393977534 no 882 0.259673773174008 1325 16798029 SGTC_38 0929-0051 58.268 µM 0.640869379729821 0.253405254420905 no 883 0.260803775790998 1282 1379719 SGTC_335 4077-0256 27.6 µM 0.640661151226898 0.25347299126283 no 884 0.260871429856672 1298 3121989 SGTC_2245 6637752 200 µM 0.640236663715052 0.253611106736935 no 885 0.26100937507637 1245 681890 SGTC_1036 k216-0215 33.5 µM 0.639773869700872 0.253761731025807 no 886 0.261159811438554 1277 622330 SGTC_2 0422-0095 29 µM 0.638951863857784 0.254029382755339 no 887 0.261427123438644 1174 6790840 SGTC_2469 5655019 90.81 µM 0.637521353263417 0.254495521449254 no 888 0.26189265279112 1367 2788239 SGTC_1587 estradiol valerate 56.1 µM 0.637062845856909 0.254645023059799 no 889 0.262041954223259 1270 13791 A steroid. SGTC_2969 9091408 28.7 µM 0.635550428092117 0.255138490155545 no 890 0.26253474424306 1255 4286311 SGTC_3114 9122766 49.47 µM 0.634444471634268 0.255499654600714 no 891 0.262895397275793 1224 17176985 SGTC_1027 k015-0025 8.67 µM 0.632887992449171 0.256008395203502 no 892 0.263403394801277 1268 3598955 SGTC_3265 9137266 49.47 µM 0.632655757509026 0.256084347278114 no 893 0.263479233664968 1250 17224265 SGTC_2524 avocatin b 10.57 µM 0.632650866007424 0.256085947162447 no 894 0.263480831158236 1236 6710748 SGTC_2536 dehydroabietamide 32.04 µM 0.631769356514351 0.25637435134101 no 895 0.263768800034559 1347 3983547 SGTC_1040 k898-0338 155 µM 0.630873242032952 0.256667707247739 no 896 0.264061704450239 1348 20969351 SGTC_405 ebelactone b 50 µM 0.630535803594537 0.256778217834878 no 897 0.264172042679023 1295 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2689 tacrolimus 100 µM 0.630256133090703 0.256869828276192 no 898 0.26426350929606 1305 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2163 5671233 125 µM 0.629668533856131 0.257062360976525 no 899 0.264455736942645 1372 701023 SGTC_1251 0490-5699 265 µM 0.62940206477571 0.257149696935839 no 900 0.264542933280627 1333 3883818 SGTC_60 0986-0278 202 µM 0.629262273760488 0.257195519987162 no 901 0.264588682765662 1123 3110598 SGTC_2217 6934799 96.0675 µM 0.628287661624947 0.257515112689837 no 902 0.264907756444741 1242 675606 SGTC_2746 daunorubicin 9.88 µM 0.628235631616231 0.257532180055945 no 903 0.26492479580132 1208 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2100 5377183 190 µM 0.628114095912476 0.257572049613871 no 904 0.264964599813445 1319 2844202 SGTC_442 cape 100 µM 0.627691110052913 0.257710834313966 no 905 0.265103155092455 1312 5281787 SGTC_2293 7624732 200 µM 0.626815957044107 0.257998101506246 no 906 0.265389941205739 1263 894453 SGTC_1686 st019653 115.5 µM 0.625977987558384 0.258273318860483 no 907 0.265664689820695 1322 97252 SGTC_4 0960-0234 25.671 µM 0.624275443000687 0.258832960014544 no 908 0.266223354199831 1312 6821112 SGTC_2589 lobaric acid 100 µM 0.62250760610906 0.259414726660421 no 909 0.266804071970356 1286 73157 A novel microtubule depolymerizer. SGTC_1002 4049-0206 172 µM 0.622342295484596 0.259469162238431 no 910 0.266858407662941 1310 4662749 SGTC_2187 6125751 200 µM 0.621633794003366 0.259702533397306 no 911 0.267091347227385 1289 874498 SGTC_3230 9131665 49.47 µM 0.620657378006049 0.260024329546153 no 912 0.267412539282018 1254 15943720 SGTC_909 3448-9333 149 µM 0.618795361682385 0.260638561245576 no 913 0.268025589108483 1287 3344074 SGTC_1784 st039334 36.3 µM 0.618533152597919 0.260725117285713 no 914 0.268111975568547 1388 3496984 SGTC_1604 st002052 72.4 µM 0.618124035874831 0.260860197535493 no 915 0.268246789674843 1343 6254834 YHR062C RPP1 SGTC_1855 st056195 39.6 µM 0.617688136741654 0.261004160276935 no 916 0.268390466767114 1311 4028379 SGTC_1067 clotrimazole 1.36 µM 0.616844801784907 0.261282801214762 no 917 0.268668548957666 1326 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2442 5158906 48.48 µM 0.615072653388187 0.261868823067057 no 918 0.269253370462966 1382 1893835 SGTC_1705 st027868 56.3335 µM 0.613974036609065 0.262232456688078 no 919 0.269616242101436 1331 292948 SGTC_2836 9010338 19.48 µM 0.612887139376949 0.262592465619214 no 920 0.269975483733873 1206 2994051 SGTC_3074 9116018 49.47 µM 0.612808732992659 0.262618445652183 no 921 0.270001407898386 1368 17027303 SGTC_1228 0124-0032 52.5 µM 0.611957902143964 0.262900453849678 no 922 0.27028280536033 1388 X1228 SGTC_1143 3454-2408 5.08 µM 0.611721852598002 0.262978719986186 no 923 0.270360900605296 1273 X1143 SGTC_2069 5228469 200 µM 0.609347855601167 0.263766519697534 no 924 0.271146946535119 1280 2835210 SGTC_2593 nobiletin 86.24 µM 0.608186219752066 0.264152441140185 no 925 0.271531986557742 1278 72344 An anti-infammatory. SGTC_2852 9023854 51.95 µM 0.608157988056921 0.264161823920317 no 926 0.271541347726041 1394 19798528 SGTC_1624 st003710 6.25 µM 0.608024520011417 0.264206184211232 no 927 0.271585605722646 1348 24207033 SGTC_2202 7226349 200 µM 0.607167132373001 0.264491241475098 no 928 0.271870001042052 1289 844334 SGTC_800 3448-7362 155 µM 0.606804399251675 0.264611887125563 no 929 0.271990364136852 1403 15991913 SGTC_1771 st048882 4.1505 µM 0.606664611549523 0.264658388223603 no 930 0.272036755947303 1272 4580403 SGTC_2806 7952793 58.44 µM 0.606451925366403 0.264729147347998 no 931 0.272107348366344 1367 2972490 SGTC_1031 k035-0009 16 µM 0.605987629394426 0.264883648608524 no 932 0.272261483925794 1352 5180959 SGTC_1449 4112-4002 201 µM 0.605840509633152 0.264932614416237 no 933 0.272310333345242 1273 2059539 SGTC_205 1486-1330 71.903 µM 0.605478630181824 0.265053078170794 no 934 0.272430509768271 1335 4118834 SGTC_573 3702-0553 84.7 µM 0.605187712586658 0.265149940055421 no 935 0.272527139588279 1311 1222756 SGTC_2118 5526350 200 µM 0.60287377624779 0.265921011701699 no 936 0.273296331232784 1372 743594 SGTC_635 k038-0028 24.7 µM 0.600613267796628 0.26667537515045 no 937 0.274048799437742 1381 4035102 SGTC_673 1082-0474 110 µM 0.600007792780416 0.266877614207089 no 938 0.274250521009985 1353 3098046 SGTC_2168 5727979 200 µM 0.59957170021838 0.267023324602047 no 939 0.274395856110016 1274 695210 SGTC_2381 9035592 200 µM 0.59896385303654 0.267226489893597 no 940 0.274598494695978 1275 4749657 SGTC_1710 st031758 61.5 µM 0.598145920705492 0.267499996571671 no 941 0.274871286008784 1392 5394341 SGTC_3139 9095020 49.47 µM 0.597652224859448 0.267665150779167 no 942 0.275036004753332 1171 25236292 SGTC_2014 4013930 200 µM 0.597060732838001 0.267863088019412 no 943 0.275233416626047 1319 64556 SGTC_631 k072-0230 41.5 µM 0.594391352656699 0.268757287185723 no 944 0.276125195407413 1385 5773147 SGTC_455 paf C-16 10 µM 0.593815643657135 0.268950336771458 no 945 0.276317712376038 1330 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1701 st028638 40.4 µM 0.593052091422873 0.269206482226572 no 946 0.276573145622709 1385 3490878 SGTC_1613 st002381 52.1 µM 0.592401627689488 0.269424786875457 no 947 0.276790838322608 1341 551167 SGTC_2774 tamoxifen 10.92 µM 0.59052692838952 0.27005445800715 no 948 0.277418718864013 1373 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1403 3909-7815 62.9 µM 0.589649686816995 0.270349357234214 no 949 0.277712766490252 1358 6615483 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.589326196748554 0.270458144368333 no 950 0.277821237382235 1392 688761 SGTC_677 0929-0063 136 µM 0.589209531826558 0.270497383219005 no 951 0.277860361890085 1335 1539583 SGTC_3071 9117417 49.47 µM 0.589104414365298 0.270532740655298 no 952 0.277895616168684 1323 45595590 YGL055W OLE1 SGTC_1499 4480-0877 67.3 µM 0.586922744697206 0.271267090542833 no 953 0.278627796704817 1314 2861909 SGTC_2052 5265182 7.135 µM 0.584592954195016 0.272052393426052 no 954 0.279410723202138 1416 1239884 SGTC_1652 st011932 78 µM 0.584102799501733 0.272217753766736 no 955 0.279575575726333 1375 1551076 SGTC_2520 obtusaquinone 4.71 µM 0.583740756811738 0.272339925849431 no 956 0.279697370966416 1439 5967872 SGTC_3059 1327-0034 3 µM 0.582932865527736 0.272612648671799 no 957 0.279969247496898 1315 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_548 1436-0017 110 µM 0.581806062431973 0.272993253975507 no 958 0.280348660040615 1442 9677137 SGTC_2934 9036370 36.88 µM 0.580426609941551 0.273459556177816 no 959 0.280813482381303 1403 6462800 SGTC_1545 lovastatin 49.4 µM 0.580380105919262 0.27347528299844 no 960 0.280829158935728 1409 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2289 7946404 165.07 µM 0.577373469100002 0.274493022486953 no 961 0.281843596329611 1386 1246120 YPR165W RHO1 SGTC_2539 epi(13)torulosol 80 µM 0.575904862436647 0.274990820881802 no 962 0.282339744406995 1337 6708597 SGTC_359 0081-0058 15.9 µM 0.57525568882835 0.27521100620229 no 963 0.282559192408744 1515 3494159 SGTC_782 0083-0095 30.5 µM 0.57371858402791 0.275732703949717 no 964 0.283079125218986 1382 3591729 An indicator and reagent. SGTC_1691 st019933 84.6 µM 0.573077600097866 0.275950399241194 no 965 0.283296076573527 1385 6176082 SGTC_2216 7189485 200 µM 0.572759041878729 0.276058621528917 no 966 0.283403927397483 1389 731273 SGTC_2738 aclarubicin 5.55 µM 0.572067503085447 0.276293626453438 no 967 0.283638121958181 1353 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.571988002773696 0.276320649252732 no 968 0.283665051247986 1442 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2522 biochanin a 4.94 µM 0.571605880342156 0.276450553850213 no 969 0.283794505383201 1386 5280373 A possible chelator. SGTC_2420 aureobasidin a 50 nM 0.570511936156838 0.276822611629808 no 970 0.284165264383862 1521 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_309 k408-0051 1.48 µM 0.570066544374016 0.276974162596423 no 971 0.284316282659182 1359 3640463 SGTC_530 4358-1714 28 µM 0.567376971960356 0.277890190599328 no 972 0.285229045920775 1424 1564641 SGTC_177 1327-0068 8.361 µM 0.564824839624377 0.278760773712942 no 973 0.286096454969641 1371 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1302 1159-0335 255 µM 0.564646497978974 0.278821659187567 no 974 0.286157115870006 1379 649284 SGTC_988 1497-1057 103 µM 0.564549525863491 0.278854767986322 no 975 0.286190102405963 1421 3533044 SGTC_2952 9073731 13.78 µM 0.5638316042566 0.279099944561409 no 976 0.286434370492091 1359 16457353 SGTC_2886 9058944 51.95 µM 0.563254165873858 0.279297220898035 no 977 0.286630911854684 1297 4949929 SGTC_3080 9117754 49.47 µM 0.562622984208842 0.279512935595171 no 978 0.286845818829046 1509 9550191 SGTC_920 mycophenolic acid 780.421 nM 0.56134114085257 0.279951271364341 no 979 0.287282500262346 1397 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1983 st071813 46.9 µM 0.560761351155068 0.280149644133071 no 980 0.28748011861408 1387 11838595 SGTC_1961 st076550 68.7 µM 0.560642454181139 0.280190332680534 no 981 0.287520651980915 1390 1579337 SGTC_2315 7733312 200 µM 0.560282768425999 0.280313440634857 no 982 0.287643289504478 1370 726316 SGTC_1558 st069300 45.6 µM 0.559881961482117 0.28045065379769 no 983 0.287779976718893 1401 24208000 SGTC_1257 0669-0121 16 µM 0.559419126140527 0.280609142343817 no 984 0.287937855645533 1447 4307855 SGTC_91 0417-1751 58.384 µM 0.55937891013509 0.2806229155427 no 985 0.287951575759071 1444 6795624 SGTC_269 exalamide 29 µM 0.558845486013236 0.280805633853301 no 986 0.288133588204674 1447 3316 A derivative of salicylamide. SGTC_563 tetrahydrosecaminediol 614 µM 0.557605286509585 0.281230672175321 no 987 0.288556972881574 1471 334274 A psychoactive constituent of the cannabis plant. SGTC_3205 9113483 49.47 µM 0.557557994738845 0.281246886049 no 988 0.28857312335113 1487 17018033 SGTC_2345 9052315 157.45 µM 0.557234464568495 0.281357819719821 no 989 0.288683622581644 1419 6469265 SGTC_3307 9126885 69.2785 µM 0.556711893367936 0.2815370461842 no 990 0.288862144813463 1370 24824909 SGTC_159 3970-0959 50 µM 0.556071266163149 0.281756837476586 no 991 0.289081068534617 1459 6615653 SGTC_2259 7964009 200 µM 0.552958606713642 0.282825928140282 no 992 0.290145877352265 1428 313134 SGTC_1620 st003704 16.5 µM 0.552779721544723 0.282887428155976 no 993 0.290207127936941 1404 2834414 SGTC_2976 9009005 19.48 µM 0.552550465206273 0.282966254969151 no 994 0.290285634550622 1524 2993148 SGTC_771 0250-0039 27.3 µM 0.549680701483554 0.283953877082133 no 995 0.291269197866185 1420 3005115 SGTC_2189 6047310 154.431 µM 0.54806883495427 0.284509319460081 no 996 0.291822319404312 1362 711535 SGTC_1489 4065-0444 182 µM 0.547092428505059 0.284846037192234 no 997 0.292157616874475 1452 2877968 SGTC_1803 st050068 52.4 µM 0.546336400172897 0.285106887169549 no 998 0.292417359691598 1477 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_650 1328-0195 38 µM 0.544732248218958 0.285660739281335 no 999 0.292968841063162 1403 2780821 SGTC_92 0063-0024 660.874 µM 0.543359153531825 0.28613522244379 no 1000 0.293441271690752 1420 3594437 SGTC_608 k048-0125 159 µM 0.542751947575502 0.286345166335739 no 1001 0.293650301072789 1452 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3333 9141820 12.094 µM 0.538633796562149 0.287770959758764 no 1002 0.295069781424666 1419 1939433 SGTC_1415 3966-0071 78.1 µM 0.538601180034301 0.28778226568452 no 1003 0.295081036579335 1417 2893185 SGTC_2926 9010726 65.15 µM 0.536016741938695 0.288678780430242 no 1004 0.295973489891722 1388 2994293 SGTC_1132 3456-3614 2.5 µM 0.535727228046579 0.288779291663738 no 1005 0.296073541421855 1623 3125502 SGTC_640 3381-0960 37.1 µM 0.534360528542496 0.289253994341373 no 1006 0.296546061115866 1521 1745025 SGTC_75 0159-0059 199.013 µM 0.533626500042768 0.289509099490562 no 1007 0.296799985054994 1534 5377270 SGTC_1273 0849-0096 14.1 µM 0.533463916349988 0.289565618313088 no 1008 0.296856241416216 1429 5286025 SGTC_2220 6782180 200 µM 0.532350062647959 0.289952965526126 no 1009 0.297241782432587 1413 833803 SGTC_960 1222-0186 7.7 µM 0.531747338597101 0.290162666553117 no 1010 0.297450500213922 1501 3126296 SGTC_203 k066-0004 30.888 µM 0.531720521819427 0.290171998354139 no 1011 0.297459788171758 1490 6795412 SGTC_3039 9090270 49.47 µM 0.531413641176717 0.29027879782069 no 1012 0.297566085331842 1460 17173750 SGTC_331 k048-0133 24.5 µM 0.530300228203294 0.290666438179864 no 1013 0.297951894249493 1421 6813582 SGTC_2703 st077852 53.4 µM 0.527979157432134 0.291475308263938 no 1014 0.29875690110649 1455 6281836 SGTC_1015 4130-4525 82 µM 0.525055128986698 0.292495794964096 no 1015 0.299772433832848 1406 1363237 SGTC_2003 4023581 200 µM 0.524737161371277 0.292606865779032 no 1016 0.299882960079767 1463 16641307 SGTC_2881 9058953 51.95 µM 0.52224896539774 0.293476705490693 no 1017 0.300748498707426 1391 17122249 SGTC_645 0845-0943 5.41 µM 0.522144117337695 0.293513385240036 no 1018 0.300784995672466 1437 1885106 SGTC_1107 amlodipine 47 µM 0.521727166620494 0.293659271107042 no 1019 0.300930153422886 1380 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1485 3909-9022 254 µM 0.521429958033007 0.293763281178132 no 1020 0.301033643276258 1446 714516 SGTC_229 benomyl 22.8748 µM 0.517975778499081 0.294973341988529 no 1021 0.302237584496399 1430 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1255 0566-0045 221 µM 0.51797431283016 0.294973855925648 no 1022 0.302238095808113 1514 2788469 SGTC_3108 9121785 49.47 µM 0.517937377826972 0.294986807328564 no 1023 0.302250981042507 1528 17140271 SGTC_704 1310-0270 142 µM 0.516522027340262 0.295483302747382 no 1024 0.302744929214276 1402 5718033 SGTC_1513 0337-0559 19 µM 0.516237667228186 0.295583100705268 no 1025 0.30284421265789 1391 775073 SGTC_1408 3909-7976 48.8 µM 0.515472533119804 0.295851706214386 no 1026 0.30311142919503 1484 24152374 SGTC_979 1426-2828 121 µM 0.514420561641683 0.296221190843355 no 1027 0.303478993300635 1536 747872 SGTC_165 k038-0023 64.381 µM 0.512965854585146 0.296732476976782 no 1028 0.303987602972515 1425 46368543 SGTC_2041 5107442 45.335 µM 0.510229093370373 0.297695460366652 no 1029 0.304945486039041 1527 793005 SGTC_2837 9008476 45.46 µM 0.507961702972109 0.298494364779752 no 1030 0.305740100538548 1498 2992805 SGTC_1610 st001799 48.1 µM 0.507177993598893 0.2987707277784 no 1031 0.306014967203825 1420 621897 SGTC_2235 salicylic acid 500 µM 0.505727269271393 0.299282609924493 no 1032 0.306524061121969 1499 338 A COX inhibitor and kinase inhibitor. SGTC_1221 2958-7315 257 µM 0.505459076328013 0.29937728426533 no 1033 0.306618217396403 1474 4562705 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.504949121774857 0.299557339920833 no 1034 0.306797285728789 1508 279621 SGTC_2797 7859098 81.82 µM 0.503952149938321 0.299909494185964 no 1035 0.307147501248391 1470 972681 SGTC_786 4544-0069 423 µM 0.502756572958915 0.300332047436236 no 1036 0.307567714696316 1529 748821 YLR208W SEC13 SGTC_1800 st050079 29.0735 µM 0.502738817309368 0.300338324849636 no 1037 0.307573957239082 1429 3645560 SGTC_604 1000-0114 314 µM 0.50160895518799 0.300737903332424 no 1038 0.30797130942626 1573 1572745 SGTC_2799 7812892 81.82 µM 0.500811903113446 0.301019926954317 no 1039 0.308251753833787 1561 20205235 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.500104800491915 0.30127022320791 no 1040 0.308500643073302 1504 4213774 SGTC_950 1165-0508 94.1 µM 0.500032145736775 0.301295946443375 no 1041 0.308526221417618 1456 6148369 SGTC_871 0574-0004 149 µM 0.4989137092795 0.301692050823193 no 1042 0.308920087828715 1486 9551173 SGTC_1648 st011736 69.8 µM 0.498428536364363 0.301863951986005 no 1043 0.30909101376961 1542 2855514 SGTC_933 2914-0560 114 µM 0.498211068803045 0.301941016997972 no 1044 0.309167640796696 1629 463887 SGTC_955 1216-0110 33 µM 0.497780243635545 0.302093716651369 no 1045 0.309319471178433 1424 3619719 SGTC_532 1548-0774 215 µM 0.49754513211353 0.302177063098808 no 1046 0.309402342358352 1591 5932993 SGTC_145 3737-0113 38.366 µM 0.497244095284528 0.302283794968507 no 1047 0.309508464782857 1479 6849351 SGTC_2094 5332512 191.667 µM 0.496414854672193 0.302577887625027 no 1048 0.30980087335347 1578 755774 SGTC_1254 0550-0035 264 µM 0.496236531125514 0.302641147352388 no 1049 0.309863769911906 1578 15121435 SGTC_72 0744-0168 198.391 µM 0.494671788025031 0.303196489081817 no 1050 0.310415909512624 1534 677577 SGTC_758 0868-0029 16 µM 0.492483148485033 0.303974020815823 no 1051 0.311188915946965 1589 762687 SGTC_804 1595-0054 20.9 µM 0.491825742429482 0.304207743089559 no 1052 0.311421268379933 1476 761523 Stimulates phospholipase C. SGTC_2611 pyromycin 23.93 µM 0.48928525149578 0.305111694757148 no 1053 0.312319880547485 1465 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_972 1319-0219 195 µM 0.488655230947015 0.305336051628464 no 1054 0.312542901994492 1449 23903702 SGTC_367 0335-0881 7.1 µM 0.488413543939983 0.305422138302649 no 1055 0.312628475187709 1559 23828853 SGTC_142 0335-0849 62.6745 µM 0.486285531286369 0.306180580770875 no 1056 0.313382368101454 1543 3889043 YPR107C YTH1 SGTC_711 k292-0785 179 µM 0.485206033590884 0.306565641361031 no 1057 0.313765101271439 1471 4146315 SGTC_2828 7998861 71.43 µM 0.483120545283997 0.307310147096331 no 1058 0.314505073450328 1585 2988188 SGTC_902 1120-0002 2.07 µM 0.481695369871284 0.307819382817751 no 1059 0.315011182857114 1458 3280475 SGTC_1526 st051518 75 µM 0.481291989690355 0.307963583668511 no 1060 0.315154494685464 1506 673993 SGTC_1371 2421-0008 32.7 µM 0.47928473180849 0.308681581342569 no 1061 0.315868041262656 1525 2827552 SGTC_1885 st057546 99.9 µM 0.478060749613308 0.309119760184697 no 1062 0.316303483668358 1585 702008 SGTC_1194 1488-0194 225 µM 0.476820588942081 0.309564007960808 no 1063 0.316744941650468 1523 1391452 SGTC_2927 9011802 47.9 µM 0.47433268728613 0.310456057899167 no 1064 0.317631342809523 1453 43912568 SGTC_487 nimodipine 119 µM 0.473851336626293 0.310628777658761 no 1065 0.317802961631881 1552 4497 L-type voltage-gated calcium channels inhibitor SGTC_465 cgp-37157 41 µM 0.472032608490621 0.311281756057947 no 1066 0.318451756773372 1552 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_553 k007-0256 45.7 µM 0.471570168941724 0.311447880683554 no 1067 0.318616811818977 1550 6287000 SGTC_980 1473-0395 201 µM 0.467352160518209 0.312964907289798 no 1068 0.320123971804132 1488 768876 SGTC_2654 protoveratrine a 100 µM 0.467065227507848 0.313068219618244 no 1069 0.320226605701038 1524 5702278 A heart drug and vasodilator. SGTC_1886 st057356 49.9 µM 0.466778881823557 0.313171335108893 no 1070 0.320329043228935 1467 24207747 SGTC_2861 9024595 19.48 µM 0.46653402523337 0.313259521617182 no 1071 0.320416649276792 1513 16482810 SGTC_2364 9055074 200 µM 0.462431525095488 0.314738645872373 no 1072 0.32188594820905 1481 6470630 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.462229213515209 0.314811664948399 no 1073 0.321958477882414 1613 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2640 pentamidine 10.38 µM 0.46178984207028 0.314970269520447 no 1074 0.32211601801406 1607 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_866 0495-0101 262 µM 0.461640705900919 0.315024112544848 no 1075 0.322169499243775 1461 635694 SGTC_3056 9094900 49.47 µM 0.46094256441358 0.315276216663241 no 1076 0.32241990640817 1460 25236784 SGTC_1832 st054113 55 µM 0.459190668520657 0.31590921804129 no 1077 0.323048625503766 1558 1251267 SGTC_2776 terbinafine 19.92 µM 0.457463816978526 0.316533699057394 no 1078 0.323668851889398 1524 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1304 1165-0502 251 µM 0.456871118549644 0.316748157223932 no 1079 0.323881842083258 1571 767425 SGTC_1068 loratadine 26.9 µM 0.456179353694704 0.316998538851953 no 1080 0.324130505414516 1520 3957 A H1 histamine antagonist. SGTC_1821 st053465 65.6 µM 0.453958273261779 0.317803016528232 no 1081 0.324929429979309 1509 675086 SGTC_1026 k007-1105 30.6 µM 0.452431811163521 0.318356402081565 no 1082 0.325478967195648 1535 7066794 SGTC_1830 st055982 50.3 µM 0.452192508573163 0.318443192823593 no 1083 0.325565152281049 1632 455313 An antimicrobial agent. SGTC_57 miconazole 162.5 nM 0.45054100816295 0.31904243376823 no 1084 0.326160196008431 1487 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1768 st044301 37.178 µM 0.446909159129489 0.320361900049382 no 1085 0.327470325291505 1522 3931349 SGTC_580 1123-0028 41 µM 0.446216061132343 0.320613964436991 no 1086 0.327720591145197 1580 1677248 YPR107C YTH1 SGTC_1749 st037932 54.2 µM 0.44549644433326 0.32087576068555 no 1087 0.327980514395758 1540 594497 SGTC_464 bw-b 70c 158 µM 0.44429798858927 0.321311956007064 no 1088 0.328413577640551 1630 5353454 SGTC_1473 k844-0725 134 µM 0.442296099376605 0.322041122325276 no 1089 0.329137476595777 1610 54682906 SGTC_3157 9099274 49.47 µM 0.442035079955965 0.322136246386448 no 1090 0.32923191058591 1619 17217662 SGTC_1386 3228-0095 33.8 µM 0.441761019850531 0.322236135441984 no 1091 0.329331074280589 1654 870181 SGTC_2435 5706476 10.6 µM 0.440672057085678 0.322633165919737 no 1092 0.32972521434533 1668 5725375 SGTC_2511 berberine 10.47 µM 0.439575366979907 0.323033218237263 no 1093 0.33012234245116 1562 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2277 7947813 106.88 µM 0.43877038587227 0.323326990862341 no 1094 0.330413960194261 1675 1246798 SGTC_1152 3909-8331 15.9 µM 0.438606569860709 0.3233867879509 no 1095 0.330473317878913 1563 16001939 SGTC_3049 9092223 49.47 µM 0.436794706827113 0.324048468895634 no 1096 0.331130119040725 1580 8623917 SGTC_1871 st057448 67.3 µM 0.435770064053019 0.324422908355357 no 1097 0.331501782806164 1655 691747 SGTC_1874 staurosporine 7.6 µM 0.435396961495763 0.324559296896774 no 1098 0.331637157751034 1638 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2367 9070478 135.38 µM 0.434670678287511 0.324824858954898 no 1099 0.331900742322158 1576 572802 SGTC_803 4488-1585 147 µM 0.434016988902823 0.325063953573903 no 1100 0.332138052122302 1642 747204 SGTC_1124 fisetin 1.16336 µM 0.433876228542186 0.325115447771507 no 1101 0.332189161372946 1552 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1100 amiodarone 5.07 µM 0.433680514243969 0.325187051254657 no 1102 0.332260229258969 1696 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3034 9090421 49.47 µM 0.432405965246977 0.325653511978918 no 1103 0.332723191665422 1624 17173761 SGTC_2241 6772625 37.8075 µM 0.432083671325274 0.325771508727242 no 1104 0.332840300955418 1529 2285411 SGTC_520 3584-0023 682 µM 0.431701239135444 0.32591154566345 no 1105 0.33297928335056 1552 1340790 SGTC_1104 tacrolimus 29.8 µM 0.431037589320781 0.326154615622681 no 1106 0.333220519490827 1585 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3127 9126946 49.47 µM 0.429594304737889 0.326683491387771 no 1107 0.333745390347168 1520 27243249 SGTC_1909 st060837 51.5 µM 0.429073916199739 0.326874267574796 no 1108 0.33393471689485 1551 678937 SGTC_2431 5490079 200 µM 0.428259289388174 0.32717300337508 no 1109 0.334231177405478 1551 5722345 SGTC_293 4049-0273 38.5 µM 0.426636201994553 0.327768543746763 no 1110 0.334822162621832 1581 1380311 SGTC_336 4111-0029 111 µM 0.422929055998174 0.329130405255737 no 1111 0.336173511366603 1560 3131175 SGTC_119 0121-0043 24.815 µM 0.421502731532669 0.329654987422102 no 1112 0.336694008498198 1609 1092378 SGTC_3201 9113999 49.47 µM 0.420806116437456 0.329911314645548 no 1113 0.336948332474949 1682 16649224 SGTC_2032 5185112 25.99 µM 0.41985962138384 0.330259715957079 no 1114 0.337294003428192 1605 5718189 SGTC_2149 5554786 194.827 µM 0.419547234468127 0.330374736746372 no 1115 0.337408120916137 1616 745063 YPR165W RHO1 SGTC_3123 9126162 49.47 µM 0.418934921951157 0.330600236560882 no 1116 0.337631847055984 1617 25239884 SGTC_356 1634-0012 32.5 µM 0.417663649371128 0.331068611685375 no 1117 0.33809652658093 1706 735457 SGTC_2026 5148700 152 µM 0.417259272987167 0.331217651608827 no 1118 0.338244387265963 1580 79838 SGTC_290 2043-6722 48.1 µM 0.417041034445047 0.331298098317273 no 1119 0.33832419680501 1615 773758 YLR208W SEC13 SGTC_2857 9024691 58.44 µM 0.41662083338874 0.331453014018112 no 1120 0.338477884217291 1600 16478292 SGTC_3202 9113761 49.47 µM 0.416104732381109 0.331643324657842 no 1121 0.338666683597645 1757 4798415 SGTC_204 PMA1.184 62.41 µM 0.415325839920733 0.331930621112253 no 1122 0.338951693759241 1602 2252213 YGL008C PMA1 SGTC_471 1-acyl-paf 4 µM 0.414875644793855 0.332096721813538 no 1123 0.339116469969317 1537 16759367 SGTC_2504 purpurogallin 52.29 µM 0.414426527332693 0.332262457785113 no 1124 0.339280882410809 1583 5281571 An antioxidant. SGTC_1882 5615643 20 µM 0.411977981652417 0.333166610863135 no 1125 0.340177780942008 1574 2253075 SGTC_1059 3448-6867 171 µM 0.411683412858408 0.333275449211657 no 1126 0.340285742128043 1676 3934407 SGTC_1443 4112-3303 14 µM 0.41148400993825 0.333349133297026 no 1127 0.340358831896591 1603 704433 SGTC_1702 st027038 51 µM 0.408977800865998 0.334275784295951 no 1128 0.341277976181309 1624 5521182 SGTC_1897 st060201 15 µM 0.408886255740686 0.334309651552845 no 1129 0.341311567940951 1567 611878 SGTC_2225 6654152 15.4 µM 0.407404305113626 0.334858088895483 no 1130 0.341855532771908 1675 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_998 3996-0085 177 µM 0.406284972329958 0.335272563036561 no 1131 0.342266612919219 1754 715391 SGTC_1161 k007-0610 110 µM 0.406121350962742 0.335333166684581 no 1132 0.342326719298701 1661 5843850 SGTC_2048 5246248 200 µM 0.406075266778766 0.335350236559281 no 1133 0.342343649064437 1695 677046 SGTC_3062 9077494 49.47 µM 0.405706768805166 0.335486742775312 no 1134 0.342479034111009 1658 16459633 SGTC_2909 7941780 10.49 µM 0.404802251548471 0.335821903777317 no 1135 0.342811436819973 1751 1243215 SGTC_1925 st057770 10.1 µM 0.404386859745228 0.335975867381214 no 1136 0.342964130719787 1519 5989122 SGTC_2580 diallyl disulphide 81.36 µM 0.401718034955761 0.336965714106892 no 1137 0.343945775077249 1619 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1904 st060225 78 µM 0.399792826091059 0.337680461491127 no 1138 0.344654557515037 1599 66595 SGTC_1468 k284-1086 134 µM 0.399512459988407 0.337784598317312 no 1139 0.344757822319386 1629 15996457 SGTC_214 4373-3496 70 µM 0.39913564306923 0.337924579584926 no 1140 0.344896630232413 1698 3779166 SGTC_2101 5377231 179.231 µM 0.395996462849988 0.339091602898202 no 1141 0.34605381881426 1721 2844213 SGTC_727 3032-0951 202 µM 0.395705329270428 0.339199913360539 no 1142 0.346161211781285 1663 3652836 SGTC_2592 piperlongumine 83.33 µM 0.395433205000942 0.33930116380295 no 1143 0.346261603806776 1566 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1952 st077036 64.1 µM 0.39441074613645 0.339681698108633 no 1144 0.346638905608934 1606 2937007 SGTC_1634 st006576 41 µM 0.393628675417629 0.339972876159117 no 1145 0.346927603519356 1769 3915356 SGTC_443 clozapine 122 µM 0.393566560512003 0.339996006676037 no 1146 0.346950536771374 1717 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1176 0848-0131 83.3 µM 0.393314264646241 0.340089963485119 no 1147 0.347043691909455 1771 6769040 SGTC_3115 9123671 49.47 µM 0.392147874924615 0.340524464482329 no 1148 0.347474477769173 1697 3286988 SGTC_1225 1216-0074 20.6 µM 0.390608874359452 0.341098093627625 no 1149 0.348043182497312 1614 4241466 SGTC_2432 5630864 12.22 µM 0.390371995350778 0.341186417815111 no 1150 0.348130746463971 1599 5714970 SGTC_2138 5575593 77.673 µM 0.390057053703243 0.341303862401402 no 1151 0.348247179365142 1614 762213 SGTC_488 nitrendipine 139 µM 0.390039478111142 0.341310416951485 no 1152 0.34825367742578 1681 4507 Dihydropyridine L-type calcium channel blocker. SGTC_302 1094-0063 18.9 µM 0.389588856969945 0.341478485604387 no 1153 0.348420296607885 1625 5440289 SGTC_2965 9082772 38.63 µM 0.389557520521864 0.341490174362765 no 1154 0.348431884487923 1800 16459634 SGTC_1219 1469-0211 33.1 µM 0.389484849917309 0.341517281693818 no 1155 0.348458757836963 1751 6822282 SGTC_504 lovastatin 124 µM 0.388619735308631 0.341840046434979 no 1156 0.348778732748372 1586 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3006 9075424 71.4286 µM 0.388565246059036 0.341860379648037 no 1157 0.348798889974319 1585 7465181 SGTC_144 4161-2749 112.381 µM 0.388382304166747 0.34192864961551 no 1158 0.348866568849979 1602 797501 YMR168C CEP3 SGTC_1384 3089-0840 101 µM 0.387496019320011 0.342259465143552 no 1159 0.349194515662657 1749 1069836 SGTC_1329 1447-1697 50.6 µM 0.387480009175602 0.342265442219505 no 1160 0.349200440839497 1657 2840515 SGTC_314 1671-0008 2.74 µM 0.387183985644889 0.342375963964063 no 1161 0.349310002485978 1638 3913060 SGTC_265 mycophenolic acid 32.932 µM 0.385587278716259 0.342972334412067 no 1162 0.349901178067613 1722 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_722 3534-0461 190 µM 0.385348833606505 0.343061427348143 no 1163 0.349989492875181 1613 658262 SGTC_2891 9063876 19.48 µM 0.382930305288784 0.34396558170096 no 1164 0.35088572025744 1754 6472478 SGTC_3093 9117344 49.47 µM 0.381713526751766 0.344420806068098 no 1165 0.351336932797418 1665 24824913 SGTC_1973 st070275 50.2 µM 0.381692763551452 0.344428576009126 no 1166 0.351344634142699 1672 17118334 SGTC_1974 st069448 26.9 µM 0.380835439538217 0.344749458453532 no 1167 0.351662680200663 1760 6323587 YNR016C ACC1 SGTC_2021 4019055 173 µM 0.379898854594505 0.345100134665168 no 1168 0.352010248806851 1663 44827708 YER133W GLC7 SGTC_1978 st071761 42 µM 0.379400421018957 0.345286812475635 no 1169 0.352195268980533 1610 5147680 SGTC_2323 6148992 148.28 µM 0.379321856551268 0.345316240580082 no 1170 0.35222443556137 1621 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_583 1488-1091 88.9 µM 0.377800692431761 0.345886211284859 no 1171 0.352789329646562 1780 4303273 SGTC_614 0462-0418 107 µM 0.377489979343385 0.346002676556745 no 1172 0.352904754927744 1602 5188303 SGTC_3055 9094636 49.47 µM 0.376857836097337 0.346239669167456 no 1173 0.353139628504418 1711 25236176 SGTC_2361 9034121 116 µM 0.37636058529864 0.346426132472801 no 1174 0.353324421957793 1643 6496917 SGTC_2677 mitomycin C 100 µM 0.373906051391736 0.347347098937963 no 1175 0.354237107058894 1673 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1950 st077106 7.18 µM 0.3735780719309 0.347470228652728 no 1176 0.354359125340854 1629 13831864 SGTC_3144 9087057 49.47 µM 0.373458955403952 0.347514951242978 no 1177 0.354403443994249 1826 17249618 SGTC_3260 9137109 49.47 µM 0.372648804616059 0.347819180613457 no 1178 0.35470492205086 1761 17478346 SGTC_707 0865-0008 204 µM 0.372418131617686 0.347905821312227 no 1179 0.354790778095022 1727 723043 SGTC_2931 9014674 55.67 µM 0.371563653792995 0.348226832054817 no 1180 0.355108877325447 1595 2996810 SGTC_1783 st039459 87.517 µM 0.371452808574864 0.348268482427558 no 1181 0.355150149440036 1799 729761 SGTC_1752 st044819 83.042 µM 0.370735379137821 0.348538102595679 no 1182 0.355417318230388 1608 441209 YML126C ERG13 SGTC_2898 9056270 58.44 µM 0.367485050857289 0.349760579180473 no 1183 0.356628620348666 1689 19154699 SGTC_3097 9117246 49.47 µM 0.366989334941757 0.349947159577655 no 1184 0.356813486654324 1652 16423892 SGTC_2662 daunorubicin 22.37 µM 0.366708417919275 0.350052908825193 no 1185 0.356918263388693 1651 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1753 st043925 64 µM 0.365616606665355 0.35046402390251 no 1186 0.35732559076563 1789 670181 SGTC_2945 9067681 61.76 µM 0.365505963479026 0.350505695727196 no 1187 0.357366878044126 1710 16456930 SGTC_3014 9081533 49.47 µM 0.365012284332493 0.350691653277566 no 1188 0.35755111820882 1793 21367265 SGTC_954 1189-0853 2.85 µM 0.364474535607165 0.35089425153447 no 1189 0.357751842840387 1676 2828194 SGTC_3262 9137218 49.47 µM 0.364031961047306 0.351061024483719 no 1190 0.357917071477197 1665 17650664 SGTC_3131 9127911 49.47 µM 0.363469084123693 0.351273171761404 no 1191 0.358127251671331 1713 45595681 SGTC_3107 9121808 49.47 µM 0.362225014578744 0.35174222363568 no 1192 0.358591944031787 1781 662681 SGTC_2025 5147754 141 µM 0.35946653694064 0.352783057609675 no 1193 0.35962305342278 1776 315777 YLR208W SEC13 SGTC_1515 3460-0031 42.1 µM 0.358109624675276 0.353295455484905 no 1194 0.360130638309222 1716 2876596 SGTC_1703 st026983 48.3 µM 0.35701603534034 0.353708610894622 no 1195 0.360539900648906 1799 1104023 SGTC_828 2074-0507 139 µM 0.356753023289581 0.353808001943813 no 1196 0.360638353526353 1784 X828 SGTC_816 0325-0417 81.3 µM 0.355801120140046 0.354167805036554 no 1197 0.360994755079638 1666 68101 SGTC_85 0868-0259 160.055 µM 0.354065539190434 0.354824159927565 no 1198 0.361644883556749 1719 83173 SGTC_417 st075190 100 µM 0.353765392162707 0.354937712083352 no 1199 0.361757355728869 1817 222757 SGTC_791 1348-1292 225 µM 0.353612438976909 0.354995582561291 no 1200 0.361814675490297 1797 5437054 SGTC_2008 4012253 172 µM 0.353459903153621 0.355053298460085 no 1201 0.361871841931222 1676 603940 SGTC_279 1273-0055 2.93 µM 0.352697417033063 0.355341854771388 no 1202 0.362157647994749 1824 2847562 SGTC_2396 5342950 42.78 µM 0.352511957509495 0.355412052880741 no 1203 0.362227176240887 1677 1886677 SGTC_2439 5492030 7.2 µM 0.352186518809532 0.35553524623183 no 1204 0.362349193266385 1806 5722370 SGTC_2028 5153890 36.43 µM 0.351364252442455 0.355846578675715 no 1205 0.362657548622412 1683 2830968 YPR165W RHO1 SGTC_1432 4049-0298 68.4 µM 0.351294567417625 0.355872967747361 no 1206 0.362683685068246 1818 741646 SGTC_2221 6807166 181.081 µM 0.34903990483348 0.356727159531014 no 1207 0.363529675749921 1751 674925 SGTC_2099 5377090 177.372 µM 0.347567577161416 0.357285347614098 no 1208 0.364082479754861 1679 2243829 SGTC_709 3807-1509 243 µM 0.346362743080813 0.357742351044551 no 1209 0.364535060480496 1720 1886677 YPL242C IQG1 SGTC_2320 7373003 200 µM 0.3452626856113 0.358159790040775 no 1210 0.36494844818653 1640 5415828 SGTC_1131 3454-3128 32.3 µM 0.344527028712679 0.35843904456538 no 1211 0.365224986410984 1802 710982 SGTC_1222 0366-0074 1.18 µM 0.342236452037527 0.35930902921454 no 1212 0.366086477448187 1849 286520 SGTC_1669 st015249 58.4 µM 0.341375858425253 0.35963608043096 no 1213 0.366410323454495 1857 722793 SGTC_2124 5246320 200 µM 0.341210966760664 0.359698755922573 no 1214 0.366472383944152 1738 579342 SGTC_2728 chlorpromazine 9.18 µM 0.340527716567413 0.359958500221583 no 1215 0.366729576899759 1749 2726 A thorazine and dopamine antagonist. SGTC_339 3091-4833 71.4 µM 0.337602160976155 0.361071409096497 no 1216 0.367831506740371 1750 3240077 SGTC_858 0438-0351 2.77 µM 0.336616621211344 0.361446583224701 no 1217 0.368202962412533 1691 2799119 SGTC_1731 st035964 63 µM 0.335777196690369 0.361766239485349 no 1218 0.368519443607089 1681 6739575 SGTC_22 0964-0034 14.468 µM 0.335532418764001 0.361859470090284 no 1219 0.368611746987602 1715 138402 SGTC_1209 2323-2347 50.3 µM 0.335514924236054 0.361866133690662 no 1220 0.368618344294652 1838 5412760 SGTC_3183 9108214 49.47 µM 0.335298810313815 0.361948454130313 no 1221 0.368699845537368 1781 4974831 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.334018277687438 0.362436355623703 no 1222 0.36918288319673 1845 688798 SGTC_400 oxethazaine 37.5 µM 0.333233445888546 0.362735498446333 no 1223 0.369479036655585 1719 4621 A local anesthetic. SGTC_663 1486-0733 13.9 µM 0.332287735453613 0.363096072330978 no 1224 0.369835999984489 1747 722445 YPR165W RHO1 SGTC_3075 9116269 49.47 µM 0.332168330882345 0.363141606710425 no 1225 0.369881077844576 1749 17015205 YNL244C SUI1 SGTC_939 1165-0479 45.3 µM 0.332083594731195 0.363173921622195 no 1226 0.36991306869583 1837 1377347 SGTC_26 0302-0163 425.158 µM 0.331682689539795 0.363326823711607 no 1227 0.370064436584078 1770 3100915 SGTC_140 0062-0056 502.533 µM 0.331516060212673 0.363390381236323 no 1228 0.370127355958798 1647 3758964 SGTC_3138 9097216 49.47 µM 0.330231062601546 0.363880644864066 no 1229 0.370612688781027 1827 25237486 SGTC_2781 5567276 71.43 µM 0.329814966957753 0.364039445162531 no 1230 0.370769888801782 1789 2853274 SGTC_875 0709-0210 25.7 µM 0.328001412166703 0.364731849343721 no 1231 0.371455297443155 1859 6251364 SGTC_595 3909-8003 73.7 µM 0.327744972265145 0.364829792213522 no 1232 0.371552248412933 1766 699517 SGTC_3002 9075603 71.4286 µM 0.326458370725246 0.365321320885745 no 1233 0.372038790403431 1750 20105405 SGTC_2252 omeprazole 400 µM 0.326327832380402 0.36537120366939 no 1234 0.372088166293591 1823 4594 A proton pump inhibitor. SGTC_1618 st003135 44.5 µM 0.324921812003894 0.36590863223937 no 1235 0.372620124110965 1842 1270615 SGTC_2534 helenine 20.12 µM 0.323981272461271 0.366268285291565 no 1236 0.372976106309078 1726 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1844 rapamycin 4 nM 0.322140174182214 0.366972643008827 no 1237 0.373673252260398 1756 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_928 2764-0428 58.7 µM 0.320656068056255 0.367540750830422 no 1238 0.374235521575227 1801 662578 SGTC_2666 tannic acid 100 µM 0.320513932929047 0.367595174626777 no 1239 0.374289385033827 1768 16134267 A thiamine antagonist. SGTC_1596 piperlongumine 63 µM 0.31951518814198 0.367977670738598 no 1240 0.374667938017976 1861 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2647 atorvastatin 60.16 µM 0.319328794854409 0.368049069558807 no 1241 0.374738599820532 1821 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_859 0439-0102 54.6 µM 0.319228509986814 0.368087486032431 no 1242 0.3747766196119 1874 610143 SGTC_1055 3448-0672 86 µM 0.318881331906625 0.368220490935878 no 1243 0.374908250445417 1756 748378 SGTC_519 k048-0011 62.8 µM 0.318744384120818 0.368272960364769 no 1244 0.374960177522708 1789 6836379 SGTC_2441 5730946 39.09 µM 0.317850756009394 0.368615400456746 no 1245 0.375299073927882 1838 1774275 SGTC_56 0957-0365 83.25 µM 0.317768123655704 0.368647070616387 no 1246 0.375330415999668 1814 6752360 SGTC_3219 9131112 49.47 µM 0.317231018614931 0.36885294637622 no 1247 0.375534157523246 1778 17612988 YMR079W SEC14 SGTC_1872 amphotericin b 148 nM 0.315729243149717 0.369428785989526 no 1248 0.376104014195046 1846 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_846 0335-0850 148 µM 0.314691980218152 0.369826684465372 no 1249 0.376497766989783 1782 6819598 SGTC_1 0258-0098 57.368 µM 0.314425999666758 0.369928738211297 no 1250 0.376598755926775 1757 6790032 YDR047W HEM12 SGTC_702 1488-0190 94 µM 0.312299469255967 0.370744992849599 no 1251 0.37740647168371 1895 949357 SGTC_330 1488-0319 80.1 µM 0.31221909187166 0.370775856616343 no 1252 0.377437011808451 1785 6846614 SGTC_1674 st016616 23.6 µM 0.311881969336307 0.370905315906933 no 1253 0.377565112955905 1653 625830 SGTC_1391 3442-0225 151 µM 0.311855413553464 0.370915514282411 no 1254 0.377575204299231 1772 5227075 SGTC_3264 9137442 49.47 µM 0.310038081942153 0.371613650042209 no 1255 0.378265998505407 1856 17015726 SGTC_2908 7930301 100 µM 0.309916105865223 0.371660522832178 no 1256 0.378312377353796 1704 2223178 SGTC_21 0849-0113 22.993 µM 0.304379244202472 0.373790213524796 no 1257 0.38041948940988 1743 1560156 SGTC_2070 5230947 200 µM 0.304239988365854 0.373843826714232 no 1258 0.380472530775227 1874 2835538 SGTC_2023 5144124 124 µM 0.304146047293816 0.373879995198221 no 1259 0.380508313401032 1756 2830192 SGTC_552 k242-0005 476 µM 0.303662753759039 0.374066086781401 no 1260 0.380692418487584 1774 4088318 SGTC_1791 st048313 56.1 µM 0.302769485045719 0.374410116037662 no 1261 0.38103276997681 1898 1204976 SGTC_597 k018-0003 82.8 µM 0.302085357248992 0.374673665405792 no 1262 0.38129349727173 1865 6786234 SGTC_2608 thymoquinone 42.66 µM 0.301550150863925 0.374879885992443 no 1263 0.381497506844197 1808 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2313 7726885 200 µM 0.301305339009263 0.374974226476129 no 1264 0.381590835024057 1776 726423 SGTC_164 4100-3994 89.624 µM 0.298570254360565 0.376028723792144 no 1265 0.382633982151399 1924 4615967 SGTC_2497 7-hydroxyflavone 100 µM 0.29825102613194 0.376151861052275 no 1266 0.38275578981892 1875 5281894 SGTC_383 2324-0395 7.37 µM 0.29812907114247 0.376198906597505 no 1267 0.382802327151961 1842 3146421 SGTC_1883 5-benzylidenerhodanine 20 µM 0.298034606376914 0.376235348735844 no 1268 0.382838375534258 1904 1273210 SGTC_191 3914-0123 66.505 µM 0.297601271675022 0.37640253253629 no 1269 0.383003751937937 1752 3144412 SGTC_2720 fluspirilene 36.88 µM 0.297259755349967 0.376534308455373 no 1270 0.383134102113732 1845 3396 An atypical antipsychotic. SGTC_497 capsazepine 133 µM 0.296621639460362 0.376780567470053 no 1271 0.383377694060108 1692 2733484 A calcium channel blocker. SGTC_926 2268-1401 59.4 µM 0.296022469987828 0.377011842095125 no 1272 0.383606460725793 1759 2931578 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.295270793328113 0.377302045677828 no 1273 0.383893512970819 1786 390807 SGTC_2506 ethyl hematommate 54.16 µM 0.295238883042156 0.377314366976787 no 1274 0.38390570036506 1712 3940691 An allergen. SGTC_850 0388-0143 75.9 µM 0.294472361355004 0.377610376221726 no 1275 0.38419849003966 1781 67273 SGTC_1724 st037281 8.293 µM 0.294025946989983 0.37778280210983 no 1276 0.384369038207662 1742 574124 YDL195W SEC31 SGTC_1061 3448-9325 110 µM 0.293927901713898 0.377820674996127 no 1277 0.38440649842966 1893 723482 SGTC_2537 larixol 68.93 µM 0.293789683812523 0.377874067741345 no 1278 0.384459309266157 1823 6708759 SGTC_2338 7999974 200 µM 0.293433702447339 0.378011591945215 no 1279 0.384595333890854 1960 315925 SGTC_2117 5521686 200 µM 0.292409420460198 0.378407383012403 no 1280 0.384986803173628 1747 803312 SGTC_992 3909-8734 162 µM 0.291399057102407 0.378797920826326 no 1281 0.385373067798369 1749 4288319 SGTC_3199 9111318 49.47 µM 0.290785952734198 0.379034965685615 no 1282 0.385607514718478 1866 8548020 SGTC_2193 5925765 200 µM 0.290070693546852 0.37931156421277 no 1283 0.385881077766609 1880 877370 SGTC_348 k064-0012 10.7 µM 0.287890762401771 0.380154947954675 no 1284 0.38671517912283 1759 5066323 SGTC_1463 k081-0032 34.1 µM 0.286928536999596 0.380527400629335 no 1285 0.387083519705685 1733 977755 SGTC_2197 6588183 93.1375 µM 0.286559537397689 0.380670260277042 no 1286 0.387224800019114 1851 884136 SGTC_2460 5552655 174.22 µM 0.283876619173552 0.381709450762358 no 1287 0.388252467453103 1769 5401989 SGTC_767 0929-0023 86 µM 0.283627342444633 0.381806048011812 no 1288 0.388347990496605 1793 1204563 SGTC_1317 1273-0028 910 nM 0.282696914476827 0.382166663203793 no 1289 0.38870459085086 1813 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2617 dihydrotanshinone i 20.83 µM 0.282334870950633 0.38230701165183 no 1290 0.388843374784521 1772 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1971 st069429 63.5 µM 0.281782598596778 0.382521133280412 no 1291 0.389055107395457 1925 1246522 YGL099W LSG1 SGTC_737 1950-0117 57.9 µM 0.281336983185721 0.382693929112057 no 1292 0.389225973421197 1932 5393513 SGTC_2341 7987486 176.74 µM 0.280524295594844 0.383009124259344 no 1293 0.389537644126276 1953 1258686 SGTC_585 0kpi-0023 191 µM 0.279574921294869 0.383377430493706 no 1294 0.389901825009663 1904 64601 SGTC_3315 9136395 68.55 µM 0.279238962929729 0.383507789564538 no 1295 0.3900307221316 1964 16876844 SGTC_477 mead ethanolamide 10 µM 0.278976703703743 0.383609560950909 no 1296 0.39013135151531 1834 16061185 SGTC_454 lyso-paf C-16 6.67 µM 0.27738512184355 0.384227356568083 no 1297 0.390742202315966 1724 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_648 0375-0473 33.3 µM 0.277312077527523 0.384255716854049 no 1298 0.390770243286374 1828 1713139 SGTC_3069 9117009 49.47 µM 0.277215418892298 0.384293246620372 no 1299 0.390807350426984 1920 41904981 SGTC_1924 st058459 75.1 µM 0.275118489368796 0.385107690473838 no 1300 0.391612603517665 1851 688683 SGTC_2942 9052777 62.25 µM 0.274049387581349 0.385523123193501 no 1301 0.392023334056851 1813 6469503 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.271885176483809 0.386364496355326 no 1302 0.392855154748335 1864 2724278 An inhibitor of dopamine biosynthesis. SGTC_741 4582-0002 126 µM 0.271554468591528 0.38649311174798 no 1303 0.392982306480742 1789 2912688 SGTC_3134 9127454 49.47 µM 0.270475492228311 0.386912822395297 no 1304 0.393397234443261 1872 24262820 SGTC_545 4218-0007 221 µM 0.268713969014819 0.387598320772996 no 1305 0.394074900661651 1841 2840508 SGTC_1569 carminic acid 40.6 µM 0.26809252404548 0.387840240411323 no 1306 0.394314050109809 1960 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.267378694995687 0.388118177578796 no 1307 0.394588800709619 1949 6708630 An antioxidant. SGTC_1288 0973-0013 65.5 µM 0.266918262781491 0.388297482326671 no 1308 0.394766047480634 1850 4315430 SGTC_2754 granisetron 64.02 µM 0.265818783904036 0.388725745362882 no 1309 0.395189388024609 1944 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1170 0310-0127 64.8 µM 0.265328910930528 0.388916601614519 no 1310 0.395378047343514 1869 774975 SGTC_1902 st060212 70.5 µM 0.26443216092949 0.389266048033951 no 1311 0.39572346618157 1931 688944 SGTC_1727 st034309 9.9045 µM 0.264093584001199 0.389398008333015 no 1312 0.395853903834635 1957 870305 SGTC_567 1080-0542 68.4 µM 0.26377078426395 0.389523831352237 no 1313 0.395978274144641 1948 5950415 SGTC_2286 7945697 125 µM 0.263445973144397 0.389650450071428 no 1314 0.39610343010179 1770 1245733 SGTC_2406 ethylparaben 405.7 µM 0.262990684388163 0.389827951637854 no 1315 0.396278879620913 1602 8434 A possible steroid mimic. SGTC_2250 alverine citrate 130 µM 0.260139852793306 0.390939914733941 no 1316 0.397377948882546 1798 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_40 0327-0103 19.753 µM 0.258908576967099 0.391420448683577 no 1317 0.397852890158439 1780 409036 SGTC_2887 9044784 58.44 µM 0.258864986495109 0.391437463918556 no 1318 0.397869707134869 1943 6465546 SGTC_2195 6536160 144.242 µM 0.258699416380756 0.391502094944049 no 1319 0.39793358494927 1817 3834386 SGTC_2356 9061756 188.97 µM 0.258187915027405 0.391701780669393 no 1320 0.398130942117463 1969 20104043 SGTC_3347 9188721 44.724 µM 0.258139669957009 0.391720616603106 no 1321 0.398149558292891 1900 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_852 0418-0143 439 µM 0.257144787928606 0.392109096895729 no 1322 0.398533501957445 1956 5369229 SGTC_1106 tegaserod maleate 11.7 µM 0.256334848897852 0.392425440330478 no 1323 0.398846145202474 1876 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_393 acivicin 6.25 µM 0.25592768565181 0.392584495735231 no 1324 0.399003338155082 1867 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1922 5578187 25 µM 0.254470346209684 0.393153941809032 no 1325 0.399566105256072 1961 1350412 SGTC_2614 arthonioic acid 13.39 µM 0.25387074492089 0.393388298652479 no 1326 0.399797708333968 1850 6710684 SGTC_1512 0259-0544 12.2 µM 0.253632218295686 0.393481538595903 no 1327 0.399889851866502 1887 18476 SGTC_3341 9147222 25.867 µM 0.253629967014052 0.393482418649923 no 1328 0.399890721569741 1871 1939759 SGTC_2715 st079500 56.4 µM 0.253402804791121 0.393571221988102 no 1329 0.399978480233217 1818 28246688 SGTC_1994 st072947 40.9 µM 0.252346652705117 0.393984170627368 no 1330 0.400386565477155 1893 5286565 YDL195W SEC31 SGTC_387 norethindrone acetate 66.7 µM 0.251454526596448 0.394333079079839 no 1331 0.400731357699739 1827 541197 SGTC_407 eburnamonine 100 µM 0.251086650284007 0.394476979363156 no 1332 0.400873558448283 1829 3195 SGTC_1264 0783-0040 158 µM 0.249942262548467 0.394924715621498 no 1333 0.401315999709843 1783 2855798 SGTC_133 0724-0033 378.92 µM 0.248552431148007 0.39546866714273 no 1334 0.401853504136436 1946 280309 SGTC_897 1000-0139 31.4 µM 0.248518630132678 0.395481898708859 no 1335 0.401866578683306 1982 6151020 SGTC_2923 7992654 58.14 µM 0.248344978746618 0.395549877258248 no 1336 0.401933750384521 1849 2985126 SGTC_1004 4084-0029 199 µM 0.247035141002917 0.396062735968785 no 1337 0.40244051405694 1987 716894 YLR208W SEC13 SGTC_412 gemfibrozil 100 µM 0.246244015861603 0.396372583257826 no 1338 0.402746672287977 1978 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_12 0849-0099 9.267 µM 0.245114262179051 0.396815169200844 no 1339 0.403183980048649 1981 6071388 SGTC_968 1309-0633 340 µM 0.244443505272882 0.397078004089051 no 1340 0.403443675572755 1997 3761976 SGTC_2309 7664088 163.95 µM 0.24311280287612 0.39759957570554 no 1341 0.403959006722313 2031 704922 SGTC_1657 st012939 43.4 µM 0.242166960145849 0.397970412154387 no 1342 0.404325397581122 1974 24207257 SGTC_986 1493-0483 84 µM 0.241805510040523 0.398112150220943 no 1343 0.404465434599344 1999 40079 SGTC_1087 pterostilbene 9.05 µM 0.241382064087836 0.398278216273625 no 1344 0.404629506305703 1980 5281727 Similar to reservatol, lowers cholesterol. SGTC_1421 4029-0249 71.4 µM 0.240222111550079 0.398733218056417 no 1345 0.405079036470349 2009 2894095 SGTC_2515 chrysin 20.77 µM 0.239700651715575 0.398937810244707 no 1346 0.405281164837414 1960 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_993 3909-8757 62.7 µM 0.239407001057141 0.399053034854566 no 1347 0.405395000889052 1876 4288324 YLR208W SEC13 SGTC_2382 9035899 200 µM 0.239362980999174 0.399070308497817 no 1348 0.405412066310398 1849 6462679 SGTC_2763 lisinopril 49.32 µM 0.23862571760301 0.399359642894217 no 1349 0.405697910683842 2016 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1399 3562-5772 25 µM 0.23712483785246 0.399948824422466 no 1350 0.406279971984574 1889 23847490 SGTC_2027 5150920 200 µM 0.237006163842475 0.399995420526376 no 1351 0.406326004212697 1964 786715 SGTC_304 1310-0298 97 µM 0.233319503351711 0.40144365507798 no 1352 0.40775665750094 1898 1550234 SGTC_2318 6029776 164 µM 0.232014267979179 0.401956717796702 no 1353 0.408263465952889 1935 818325 SGTC_2818 7996756 12.99 µM 0.231835354736831 0.402027058313606 no 1354 0.408332947966019 1873 2241621 SGTC_1712 st032288 53.4 µM 0.228958268309901 0.403158631632941 no 1355 0.409450675816292 1919 2883011 SGTC_2674 ligustilide 100 µM 0.228626257916092 0.403289265478732 no 1356 0.409579707087531 1925 5319022 A signalling regulator. SGTC_2203 7227154 166.4 µM 0.228601488952584 0.403299011585223 no 1357 0.409589333597167 1968 896304 SGTC_1960 st011366 51.8 µM 0.226880749174829 0.403976236000793 no 1358 0.410258235837803 1942 3972846 SGTC_2417 cerulenin 830 nM 0.226377423925878 0.404174382147207 no 1359 0.410453942646377 2007 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1929 genistein trimethyl ether 50.5 µM 0.225592193082021 0.404483556324253 no 1360 0.410759306680302 2064 136420 SGTC_2154 5570129 200 µM 0.224692069637197 0.404838041307785 no 1361 0.41110941719465 1987 673366 SGTC_1665 st014639 11.4 µM 0.223951966004931 0.405129566107264 no 1362 0.411397339733398 1957 981133 YIL048W NEO1 SGTC_212 3807-4682 38.772 µM 0.223366811208568 0.405360094262058 no 1363 0.411625016313497 2001 3125501 YBL034C STU1 SGTC_3196 9111891 49.47 µM 0.22332007799069 0.405378506743166 no 1364 0.411643200921734 1990 18891510 SGTC_468 gf-109203x 121 µM 0.222554016090572 0.405680358286063 no 1365 0.41194131432325 2033 2396 A protein kinase C inhibitor. SGTC_3258 9138477 49.47 µM 0.222201892501664 0.40581912445166 no 1366 0.412078360469551 1933 4970355 SGTC_2476 5806916 10.51 µM 0.222000962322103 0.405898313064219 no 1367 0.412156567099469 1952 2870194 SGTC_720 r052-1644 49.9 µM 0.218029962599902 0.407464110173152 no 1368 0.413702883090455 1911 1422863 YOR257W CDC31 SGTC_2884 9058502 51.95 µM 0.216628879670192 0.408016922857334 no 1369 0.414248788701923 1909 6471554 SGTC_1364 1653-0028 37.6 µM 0.216207446467579 0.408183239845573 no 1370 0.414413024688907 1927 5718652 SGTC_1511 0906-3109 28.5 µM 0.215659517198527 0.40839950275095 no 1371 0.414626579607199 1993 2882180 SGTC_3156 9099931 49.47 µM 0.215150064460838 0.408600604337252 no 1372 0.414825160975249 1909 18111053 SGTC_2223 6903751 107.57 µM 0.215119673722634 0.408612601551174 no 1373 0.414837007776072 1987 5598863 SGTC_949 1165-0505 146 µM 0.212517873525068 0.409640018796675 no 1374 0.415851517588864 1865 6244267 SGTC_1663 st014140 55.4 µM 0.21204576262191 0.409826516038446 no 1375 0.416035666291016 2031 4207120 SGTC_2710 st078562 53.7235 µM 0.211200763908978 0.410160365488399 no 1376 0.416365307342537 1975 17250908 SGTC_2597 laccaic acid a 100 µM 0.210612077491645 0.410392987349021 no 1377 0.416594993613231 1913 5491415 A textile dye. SGTC_2359 9039622 200 µM 0.210528988809555 0.41042582272472 no 1378 0.416627414406617 1972 6463596 SGTC_3309 9129340 25.759 µM 0.209254434368359 0.410929585692935 no 1379 0.417124810200648 1964 17158987 SGTC_890 0929-0006 47.2 µM 0.208908476943427 0.411066349486206 no 1380 0.417259843262713 1868 1378169 SGTC_1694 st024011 44.9 µM 0.208810407217208 0.41110512035045 no 1381 0.41729812331953 2028 2787533 SGTC_1352 1496-0991 99 µM 0.208252125701156 0.411325847774189 no 1382 0.417516055116094 1895 3000039 SGTC_1718 roemerine 11.9335 µM 0.207979257116243 0.411433741878461 no 1383 0.417622581820431 2020 235224 An aporphine alkaloid with mutagenic activity. SGTC_789 1309-1135 70.6 µM 0.207655634824463 0.411561713027891 no 1384 0.417748930386747 1989 3092424 SGTC_3329 9141233 27.5565 µM 0.205542617132965 0.412397502034649 no 1385 0.418574102576613 2027 4909101 YNL103W MET4 SGTC_3256 9138902 49.47 µM 0.205516993548208 0.412407639706423 no 1386 0.418584111263687 1993 17228773 SGTC_2793 7325131 81.82 µM 0.204226088997981 0.412918446495559 no 1387 0.419088412448962 1951 4176441 SGTC_3119 9125183 49.47 µM 0.202500727619345 0.413601396605894 no 1388 0.419762644817781 2056 22695334 SGTC_795 0685-0265 78 µM 0.201992077076673 0.41380278583657 no 1389 0.419961459048937 2037 302754 SGTC_361 000s-0510 1.45 µM 0.201331053313555 0.414064537834275 no 1390 0.420219861316005 1930 660 SGTC_1367 1812-0510 76.9 µM 0.200486407748014 0.414399055885961 no 1391 0.42055009362372 1999 1142582 YDR527W RBA50 SGTC_714 4296-0578 26.1 µM 0.198499365773586 0.415186259339599 no 1392 0.421327190459011 2074 1589775 SGTC_1824 st053723 68.6 µM 0.197873647035974 0.415434220064154 no 1393 0.421571961555717 1909 675225 SGTC_2789 5281112 71.43 µM 0.19763421628707 0.415529110942208 no 1394 0.421665631032566 1876 765948 SGTC_3213 9129884 49.47 µM 0.197227289349298 0.4156903949869 no 1395 0.42182483809976 1891 17190742 SGTC_2680 butyl paraben 22.24 µM 0.196893340111272 0.415822765192046 no 1396 0.421955502744617 2055 7184 An antifungal and steroid mimetic. SGTC_39 0986-0283 58.349 µM 0.195810617421777 0.416251998495262 no 1397 0.422379199723188 2064 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1318 1280-3875 124 µM 0.195786467019501 0.416261573793083 no 1398 0.422388651417045 1990 373245 SGTC_218 alverine citrate 93.75 µM 0.195211049545057 0.416489733486524 no 1399 0.422613864590477 2045 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1567 st069303 68.4 µM 0.195143616278547 0.416516473401251 no 1400 0.422640259016056 1940 5581319 SGTC_2224 6650123 117.647 µM 0.194233842346419 0.416877271892086 no 1401 0.422996392539138 1978 2908370 SGTC_970 1315-0089 19.5 µM 0.193842010820227 0.417032686178992 no 1402 0.423149795481457 2019 6811083 YLR033W RSC58 SGTC_3180 9109287 49.47 µM 0.193672318379823 0.417099996247049 no 1403 0.423216234078652 1967 18891271 SGTC_735 3076-0345 636 µM 0.191482006121403 0.41796902117545 no 1404 0.424073988373644 2051 2888990 SGTC_657 3534-0529 86.7 µM 0.191357013879038 0.418018625030613 no 1405 0.4241229478247 2064 1049549 SGTC_1839 st053978 48 µM 0.190887421592854 0.418204996945869 no 1406 0.424306897542772 2075 3788398 SGTC_1357 1503-1303 39.5 µM 0.190567917756883 0.418331812218126 no 1407 0.424432063713539 1974 292895 SGTC_509 pifithrin 175 µM 0.190534602029838 0.418345036157123 no 1408 0.424445115645223 2065 4817 A p53 inhibitor. SGTC_581 0958-0271 211 µM 0.190317433182386 0.418431238775917 no 1409 0.424530196801495 1933 4591145 SGTC_1935 st074532 41.6 µM 0.18987085641905 0.418608514474567 no 1410 0.424705165112009 2091 2829742 SGTC_2300 7976697 71.57 µM 0.189761466350688 0.418651941111724 no 1411 0.424748026290322 1930 2236109 SGTC_1525 8-methoxypsoralen 92.5 µM 0.189284240737415 0.418841405948019 no 1412 0.424935023064161 2092 4114 Related to psoralen; DNA damaging agent. SGTC_2489 cantharidin 73.42 µM 0.189232483814097 0.418861955258699 no 1413 0.42495530458788 2019 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2626 ethyl orsellinate 100 µM 0.189174531512561 0.418884964614158 no 1414 0.424978014074907 1959 75653 A natural product. SGTC_1167 k781-0610 148 µM 0.189107388384967 0.418911623437986 no 1415 0.425004325437638 1963 4525169 SGTC_262 fenpropimorph 62.5 µM 0.189004816348579 0.418952349841592 no 1416 0.425044520964093 2024 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1641 st009299 47.1 µM 0.188917930227249 0.418986848805103 no 1417 0.425078570165446 2067 4046054 SGTC_448 monastrol 171 µM 0.188351409079269 0.419211806693773 no 1418 0.425300593912601 2055 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1814 st052110 31.539 µM 0.187913456147269 0.419385729987316 no 1419 0.425472247084121 2051 674163 SGTC_694 1315-0438 43.2 µM 0.18509685976086 0.420504653747566 no 1420 0.42657653229932 2013 6793154 SGTC_2877 9040724 71.43 µM 0.184206185050749 0.420858618202819 no 1421 0.426925853770561 2120 6463895 SGTC_8 0354-0001 70 µM 0.183435734297862 0.421164855891574 no 1422 0.427228069804928 1990 4993152 SGTC_2248 tofa 1.1 µM 0.18308473809813 0.421304385197386 no 1423 0.427365765301585 1953 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_865 0488-0499 301 µM 0.182998418883021 0.421338700645418 no 1424 0.427399629609127 2119 9634651 SGTC_1856 st057054 55.7 µM 0.182958828362172 0.421354439710147 no 1425 0.427415161736236 2090 1266018 SGTC_2900 5328528 85.29 µM 0.182842680088377 0.421400614750643 no 1426 0.427460729599749 2014 795359 SGTC_2113 5491891 107.031 µM 0.182726672846486 0.421446734802523 no 1427 0.427506243098897 1936 789979 SGTC_83 0170-0301 39.027 µM 0.182652379415377 0.421476271601407 no 1428 0.427535391389583 2101 3089716 SGTC_1241 0364-0022 50.8 µM 0.181774074249838 0.42182549235126 no 1429 0.427880015644697 2009 4563895 SGTC_3149 9097855 49.47 µM 0.181589040068673 0.421899071185621 no 1430 0.427952625302631 2071 25236625 YMR079W SEC14 SGTC_97 0535-0701 19.132 µM 0.179804337255985 0.422608897782843 no 1431 0.428653089238212 1985 2832013 YGL099W LSG1 SGTC_2973 9094665 17.96 µM 0.178525431110176 0.423117709544621 no 1432 0.429155175424577 2081 25237061 YIL048W NEO1 SGTC_2449 5812982 45.77 µM 0.178201226938896 0.423246714320272 no 1433 0.429282473094247 2061 776185 SGTC_1311 1190-0148 100 µM 0.177058768950451 0.423701377727048 no 1434 0.429731113889295 2059 1961333 SGTC_413 propylparaben 100 µM 0.175559732989483 0.424298102302596 no 1435 0.43031991967161 1962 7175 A pharmaceutical preservative. SGTC_3184 9108758 49.47 µM 0.175349071827137 0.424381974601123 no 1436 0.430402677641159 2027 902885 SGTC_263 alizarin 107.927 µM 0.175315822464954 0.424395212762037 no 1437 0.430415739890205 2048 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2737 bleomycin 30.5 nM 0.174743160946271 0.424623230067182 no 1438 0.43064072598883 2051 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1758 st042942 75.2445 µM 0.17450724519905 0.424717172256616 no 1439 0.43073341864257 2113 669317 SGTC_923 1900-2434 73.3 µM 0.174157928352443 0.424856278874578 no 1440 0.430870674247473 1964 5910570 SGTC_478 N-arachidonylglycine 10 µM 0.17354810833719 0.425099146723175 no 1441 0.431110308274575 2098 5283389 SGTC_346 4513-0042 7.16 µM 0.173307176071366 0.42519510861461 no 1442 0.431204991677963 1986 2827372 SGTC_1831 st055328 12 µM 0.173238414307991 0.425222496830057 no 1443 0.431232014926742 2092 1103068 SGTC_2180 6301957 200 µM 0.172150717321561 0.425655780867756 no 1444 0.431659520615765 2098 845462 SGTC_2936 9038235 15.59 µM 0.171703324180631 0.425834025993105 no 1445 0.431835386155883 2060 4749415 SGTC_748 act1.228 77.9 µM 0.171273322721618 0.426005356412429 no 1446 0.432004427941834 1970 4421505 YNR035C ARC35 SGTC_1057 3448-5381 134 µM 0.171262290392684 0.426009752333864 no 1447 0.432008765124979 2084 5497911 SGTC_2630 antimycin a 100 µM 0.170285923254908 0.426398830134599 no 1448 0.432392640598345 2030 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1757 st041620 31.8375 µM 0.170012370744645 0.42650785241237 no 1449 0.432500203918057 1960 5289815 SGTC_234 nsc-17383 10.7 µM 0.168499768115604 0.427110789870476 no 1450 0.433095063039716 2086 408974 SGTC_3314 9135860 59.4275 µM 0.165232822773914 0.428413604015249 no 1451 0.434380365741562 2124 25252478 SGTC_1668 st014914 51.6 µM 0.165119241244017 0.428458912934112 no 1452 0.434425064280254 2087 2839556 SGTC_2988 9073640 71.4286 µM 0.164703582042499 0.428624731987299 no 1453 0.434588648713828 2049 9102229 SGTC_1773 st048542 73.5835 µM 0.164277765957682 0.428794615995075 no 1454 0.434756242044779 1943 3237138 SGTC_1633 st005664 67.9 µM 0.163135044269178 0.429250582497986 no 1455 0.435206054019876 2029 2063822 SGTC_613 3914-0030 117 µM 0.16313037269901 0.429252446732682 no 1456 0.43520789307251 2060 1145395 SGTC_3300 9124615 50.48 µM 0.162465512121835 0.429517781769739 no 1457 0.435469642385255 2096 24824903 SGTC_1841 st054148 70 µM 0.162305475085098 0.429581654706329 no 1458 0.435532651677379 1978 675442 SGTC_3334 9142812 21.919 µM 0.160822772687315 0.430173508641082 no 1459 0.436116494344384 2075 45283678 SGTC_3147 9097027 49.47 µM 0.160655188994852 0.43024041332767 no 1460 0.436182492436788 2042 25236841 SGTC_2867 9039098 71.43 µM 0.157702566083399 0.431419520159896 no 1461 0.437345589178604 2040 6463460 SGTC_1556 plumbagin 1.48 µM 0.15710457899084 0.431658396410644 no 1462 0.437581214442765 2120 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2961 9083290 32.55 µM 0.156117784238377 0.432052643195072 no 1463 0.437970090223551 2138 17741490 SGTC_1748 st037455 53.6035 µM 0.156018871752069 0.43209216470488 no 1464 0.438009072936393 2028 580690 SGTC_3042 9091578 49.47 µM 0.156006453956778 0.432097126411805 no 1465 0.438013966995485 2130 25236497 SGTC_1743 st037606 46.3785 µM 0.15509728304548 0.432460427642759 no 1466 0.438372312041898 2030 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2686 alizarin 95.37 µM 0.154151316009244 0.432838493084864 no 1467 0.438745213730856 1992 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1518 st038567 90.8 µM 0.150930558849922 0.434126160781172 no 1468 0.440015247068702 2139 77966 SGTC_3193 9111931 49.47 µM 0.150921652043125 0.43412972272325 no 1469 0.440018760130328 2041 17087244 SGTC_1315 1237-0019 3.69 µM 0.149623724253937 0.434648837109691 no 1470 0.440530744819758 2139 825140 SGTC_3044 9093193 49.47 µM 0.148399564008219 0.435138550984151 no 1471 0.441013722066769 1989 25236277 SGTC_1413 3910-0535 34.4 µM 0.148299949119587 0.435178405378174 no 1472 0.441053027756251 2126 2876951 SGTC_1207 2099-0101 141 µM 0.147455464480393 0.43551629718641 no 1473 0.441386264798889 2138 5837381 SGTC_2968 9090663 33.37 µM 0.147023989835663 0.435688955280757 no 1474 0.441556542465669 2002 25236811 SGTC_2830 7992007 71.43 µM 0.146247844782837 0.435999566884811 no 1475 0.441862868443686 1968 1952075 SGTC_877 0771-0151 33.1 µM 0.145717454953981 0.436211850488228 no 1476 0.442072220695917 2061 6166523 SGTC_2685 mycophenolic acid 18.85 µM 0.144060564305463 0.4368751236762 no 1477 0.442726322474341 2119 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_439 amiodarone 34.4 µM 0.141948293043427 0.437720948313275 no 1478 0.443560424081802 2085 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_130 0136-0219 337.655 µM 0.141348502715571 0.437961176643456 no 1479 0.443797317294051 2187 234244 SGTC_2990 9074105 71.4286 µM 0.140308690187892 0.438377697022493 no 1480 0.44420804923499 2154 6502001 SGTC_2446 5162541 200 µM 0.139413691717411 0.438736263548226 no 1481 0.444561626794923 2045 1549321 SGTC_1168 k815-0004 80.5 µM 0.138980501730025 0.438909832122807 no 1482 0.444732778434547 2072 642433 SGTC_114 0364-0001 490.298 µM 0.13865126640312 0.439041756480647 no 1483 0.444862864895281 2004 4003655 SGTC_84 0443-0269 128.823 µM 0.135661582838333 0.440240028685584 no 1484 0.446044409665469 2155 6150058 SGTC_969 1313-0238 134 µM 0.135591884596094 0.440267970478595 no 1485 0.446071960677235 2058 5212874 SGTC_1250 0485-0349 40.2 µM 0.134581526906361 0.440673052850331 no 1486 0.446471374053529 2077 6842794 YDL195W SEC31 SGTC_2456 5770359 74.46 µM 0.134270693735697 0.440797687598741 no 1487 0.446594263189184 2142 3118787 SGTC_2805 7950783 58.44 µM 0.132599471438303 0.441467897680204 no 1488 0.447255075230361 2088 1178958 YDL195W SEC31 SGTC_3210 9128157 49.47 µM 0.131392970449435 0.441951844936675 no 1489 0.447732224611901 1914 17590849 SGTC_2576 guaiol 23.12 µM 0.131357292607147 0.44196615722477 no 1490 0.447746335709987 2182 227829 SGTC_2670 beta-carotene 100 µM 0.130766452918724 0.442203185582699 no 1491 0.447980030879349 2165 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1190 1486-1332 13 µM 0.129936617098148 0.442536127428166 no 1492 0.448308286800625 2156 4150046 SGTC_2334 9017922 200 µM 0.129347237248279 0.442772619608779 no 1493 0.448541447711568 2146 3163164 SGTC_2115 tiliquinol 12.7705 µM 0.128648026044537 0.44305320871429 no 1494 0.448818081370557 2114 71208 A bioactive hydroxyquinoline. SGTC_1376 2910-0861 41.3 µM 0.127769199347256 0.443405916891471 no 1495 0.449165812801012 2155 1112859 SGTC_1205 4161-2785 76 µM 0.125912392748349 0.444151274507019 no 1496 0.44990063637907 1990 3498106 SGTC_2264 7948757 110.76 µM 0.124590873789186 0.44468187795029 no 1497 0.450423726879459 2122 2971411 SGTC_2792 7535235 81.82 µM 0.123330273667819 0.445188114262141 no 1498 0.450922784451055 2046 1281891 SGTC_2493 resveratrol 26.09 µM 0.121468502286153 0.445935934361707 no 1499 0.451659980737706 2147 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_719 2810-4230 27.3 µM 0.121464025403165 0.445937732829943 no 1500 0.451661753628591 2176 721079 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.120308574339576 0.446401941537106 no 1501 0.452119356054395 2122 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1597 7-benzyloxygramine 47.5 µM 0.119304129871902 0.446805542241393 no 1502 0.452517205852969 2042 260807 SGTC_370 0180-0345 38.7 µM 0.117532706223518 0.447517460599173 no 1503 0.453218963912732 2100 3989527 SGTC_1698 5-fluorocytosine 1.055 µM 0.116170849732373 0.448064892909083 no 1504 0.453758569423222 2199 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1326 1431-2094 10.8 µM 0.115706177163099 0.448251702368647 no 1505 0.453942705235201 2151 616278 SGTC_3220 9131269 49.47 µM 0.115421320228346 0.44836622732949 no 1506 0.454055590398092 2225 17722206 SGTC_619 1652-1634 108 µM 0.114535841508892 0.448722255984592 no 1507 0.454406517958732 2095 5400454 SGTC_2875 9039966 71.43 µM 0.113821314675799 0.449009579320758 no 1508 0.454689720864906 2170 6463691 SGTC_490 phenamil 164 µM 0.112313704247975 0.44961590255604 no 1509 0.455287338068171 2204 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1495 4469-0029 237 µM 0.111355290573903 0.450001413842729 no 1510 0.455667306223126 2197 793680 SGTC_433 pimozide 108 µM 0.110725815942387 0.450254638738952 no 1511 0.455916886846185 2129 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_161 4065-0411 162.148 µM 0.10703669319312 0.451739101962196 no 1512 0.457379934998809 2138 1906281 YLR208W SEC13 SGTC_855 0428-0020 25 µM 0.106371481777136 0.452006848303883 no 1513 0.457643809463185 2089 6812414 SGTC_80 0159-0065 512.242 µM 0.106322982118915 0.452026370180215 no 1514 0.457663048922655 2211 1548079 SGTC_2104 5389443 200 µM 0.105425889260771 0.452387485051704 no 1515 0.458018936936338 2188 2244536 SGTC_1201 1889-3372 45.9 µM 0.104271382301463 0.452852277064176 no 1516 0.458476993853841 2095 5392199 SGTC_1444 4112-3581 28 µM 0.104197000269332 0.452882224687728 no 1517 0.458506507227125 2168 2877249 SGTC_2752 diclazuril 33.15 µM 0.102154770547173 0.453704569404846 no 1518 0.459316913873464 2208 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1675 st018485 24.5 µM 0.101612443828749 0.453922981630405 no 1519 0.459532150915374 2095 3323024 SGTC_1187 1391-0724 117 µM 0.101471582971278 0.453979713062171 no 1520 0.459588057303558 2113 6997986 SGTC_1425 4048-4433 7.33 µM 0.101046063754631 0.454151095782989 no 1521 0.459756946843967 2226 23734946 SGTC_2064 5220758 200 µM 0.100890590668762 0.454213716473779 no 1522 0.459818656276689 2139 788518 SGTC_514 4466-0038 2.65 nM 0.100712943862887 0.454285269580388 no 1523 0.459889167952453 2115 5722064 SGTC_2058 5236698 133 µM 0.09942836381395 0.45480272054681 no 1524 0.460399081636587 2168 766665 SGTC_2682 pyrogallin 40.03 µM 0.0992333951891152 0.454881263992636 no 1525 0.460476480090162 2231 822798 An ATP competetive kinase inhibitor. SGTC_1846 st056244 14.8 µM 0.0988925252115394 0.455018588285387 no 1526 0.460611801915667 2155 5393182 SGTC_971 1315-0384 26.7 µM 0.0959662749350584 0.456197689065393 no 1527 0.461773678802793 2121 6769120 SGTC_2606 farnesol 9.78 µM 0.0958398873072879 0.456248624354553 no 1528 0.461823868830766 2220 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1989 st071868 50.2 µM 0.0951865986112554 0.456511916700939 no 1529 0.462083307205693 2262 16414057 SGTC_1362 1611-0397 101 µM 0.0947495495781417 0.45668806950271 no 1530 0.462256880053627 2198 27816 SGTC_1815 st051655 58.2 µM 0.0944100002921884 0.456824930866182 no 1531 0.462391736102347 2258 5984156 SGTC_1988 st071872 53.4 µM 0.0937186859467256 0.457103593188537 no 1532 0.46266631318452 2259 16414116 SGTC_2077 5212015 200 µM 0.0935909970534709 0.457155065694512 no 1533 0.462717030766516 2257 780900 SGTC_1623 st003709 20.3 µM 0.0932461041065467 0.457294098638163 no 1534 0.462854024066471 2181 16192618 SGTC_1334 1486-0610 236 µM 0.093018912877322 0.457385686624817 no 1535 0.462944268030547 2178 3742339 SGTC_1287 0971-0001 34.6 µM 0.0914134389076727 0.458032968306375 no 1536 0.463582041877678 2194 4665869 SGTC_288 1315-0019 35.1 µM 0.090346698979661 0.458463109324189 no 1537 0.464005855719528 2192 6811474 SGTC_2629 bisabolol 100 µM 0.0885507109890686 0.459187414316154 no 1538 0.464719490528987 2192 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_184 1494-0393 24.714 µM 0.0878395901306455 0.45947424022121 no 1539 0.465002085493784 2197 3090647 SGTC_129 0088-0017 176.636 µM 0.0840136214913778 0.461017777763685 no 1540 0.466522800837217 2264 182446 SGTC_703 3875-0075 71.8 µM 0.0840102944524296 0.461019120273522 no 1541 0.466524123457942 2183 2850814 SGTC_2663 amphotericin b 100 µM 0.0833344251094001 0.461291852824492 no 1542 0.466792814101487 2222 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_744 1594-0068 283 µM 0.082656868934244 0.461565284334619 no 1543 0.467062190532655 2211 668392 SGTC_2582 agaric acid 100 µM 0.0818774543022057 0.461879843846701 no 1544 0.46737208154572 2218 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1232 0279-0259 161 µM 0.0788439513507871 0.463104343247212 no 1545 0.46857837235655 2184 1560000 SGTC_3243 9134147 49.47 µM 0.0777890933926204 0.463530228209823 no 1546 0.468997911185592 2285 24282180 SGTC_1606 st000094 49.2 µM 0.0774891557034984 0.463651331742086 no 1547 0.469117208915011 2276 1242210 SGTC_503 tyrphostin 8 294 µM 0.0774594419442124 0.463663329221532 no 1548 0.469129027467569 2267 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2856 9022925 19.48 µM 0.0762815349172782 0.464138957459892 no 1549 0.469597558018628 2199 4944862 SGTC_2594 a-mangostin 100 µM 0.0753120332938883 0.464530471959052 no 1550 0.46998322374513 2243 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1028 k015-0029 4.8 µM 0.0744010227230439 0.464898397283042 no 1551 0.470345647522648 2273 4588309 SGTC_1406 3909-7906 11.9 µM 0.0718638636118146 0.465923224362715 no 1552 0.471355124162142 2276 X1406 SGTC_3019 9081971 49.47 µM 0.0697010238842251 0.466797032461344 no 1553 0.472215813412035 2265 16451803 SGTC_2732 terfenadine 20 µM 0.0692977900439773 0.466959960647689 no 1554 0.472376292400128 2302 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1877 wortmannin 25 µM 0.0680001707853427 0.467484306145038 no 1555 0.472892749166826 2291 312145 A covalent inhibitor of PI 3-kinase. SGTC_3165 9101544 49.47 µM 0.0651833479593547 0.468622728499758 no 1556 0.474014009666711 2259 5002184 SGTC_103 0844-0104 51.839 µM 0.0650159836880835 0.46869037714079 no 1557 0.474080637018742 2287 5375804 SGTC_3295 9122362 53.5725 µM 0.0648700543943283 0.468749362501393 no 1558 0.47413873174462 2200 4730473 SGTC_2855 9016525 58.44 µM 0.0632080511366677 0.469421200727992 no 1559 0.474800416860848 2281 43811474 SGTC_3266 9136860 49.47 µM 0.061149229201194 0.470253567087043 no 1560 0.47562018162116 2294 4871271 YPR165W RHO1 SGTC_1733 st037357 54.9 µM 0.0608214248116761 0.47038610804807 no 1561 0.475750713687328 2305 1272339 YGL099W LSG1 SGTC_2772 vinpocetine 57.06 µM 0.0599588300346912 0.470734896137695 no 1562 0.476094212268582 2273 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2328 6201408 200 µM 0.059821722520612 0.470790337300668 no 1563 0.476148812244177 2235 2890418 SGTC_2904 7225135 42.03 µM 0.0595774077662688 0.470889130474067 no 1564 0.476246106194922 2299 4446116 SGTC_139 0099-0334 718.624 µM 0.0591954282605126 0.471043594514741 no 1565 0.47639822548934 2304 97690 SGTC_1041 0206-0046 107 µM 0.0587362535251396 0.471229280358034 no 1566 0.476581091517386 2191 50494 SGTC_1045 1348-1485 165 µM 0.0541602523111296 0.473080106396522 no 1567 0.478403744119753 2319 6810614 SGTC_1423 4048-0112 5.59 µM 0.0537154377663934 0.473260049341508 no 1568 0.478580941500178 2315 X1423 SGTC_2389 9091542 195.52 µM 0.053324297095514 0.473418283848772 no 1569 0.478736760728058 2188 3626624 YOL127W RPL25 SGTC_756 0508-1999 28.3 µM 0.0528623860832513 0.473605153634493 no 1570 0.478920777014111 2263 6753853 SGTC_1096 rimcazole 32.2 µM 0.0526698460994996 0.473683048938787 no 1571 0.478997482495699 2286 18528119 A dopamine reuptake inhibitor. SGTC_250 brefeldin a 552.239 µM 0.0526338996296969 0.473697591802187 no 1572 0.479011803198502 2302 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1351 1496-0003 46.5 µM 0.0524638184214203 0.473766402032133 no 1573 0.479079562164675 2301 3891978 SGTC_55 0767-0285 6.563 µM 0.0524530510965238 0.473770758225236 no 1574 0.479083851799465 2320 3116166 SGTC_787 4152-0075 138 µM 0.0524462530701065 0.47377350854005 no 1575 0.479086560091853 2183 9566539 SGTC_2743 auranofin 4.32 µM 0.0524290765545613 0.473780457742677 no 1576 0.479093403115502 2290 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1162 k048-0130 20.1 µM 0.0520993018416027 0.473913878157676 no 1577 0.479224784631031 2264 6797406 SGTC_903 1134-0042 114 µM 0.0519024625279917 0.473993516899121 no 1578 0.479303206054477 2293 701009 SGTC_2508 celastrol 40.54 µM 0.0517846844255286 0.474041168953702 no 1579 0.47935012961729 2309 122724 Celastrol is a natural product and antioxidant. SGTC_396 dithiazanine 1.25 µM 0.0516551281667978 0.474093586782697 no 1580 0.479401746004771 2243 10578 An antihelmenthic. SGTC_2551 apiole 73.87 µM 0.0515576454928671 0.474133028091812 no 1581 0.479440584213213 2315 10659 A possible DNA adduct former. SGTC_540 1187-0821 17.3 µM 0.051248903612879 0.474257946155251 no 1582 0.479563591783741 2275 847520 SGTC_1269 0831-0796 3.05 µM 0.0502930981945752 0.474644684421133 no 1583 0.479944411827158 2316 927758 SGTC_2404 5161160 200 µM 0.0499245141324027 0.474793827414859 no 1584 0.480091271102903 2292 2831543 SGTC_1024 4507-0395 26 µM 0.049203191279115 0.475085712010204 no 1585 0.480378684037992 2217 4201836 SGTC_1428 4049-0204 61.7 µM 0.0487831160209461 0.475255702393485 no 1586 0.48054606880833 2322 X1428 SGTC_2419 paclitaxel 166.5 µM 0.0485026364253583 0.47536920559865 no 1587 0.480657831676485 2225 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_669 0108-0021 26.2 µM 0.0474217001719978 0.475806652572133 no 1588 0.481088567119042 2351 17201 SGTC_2383 9036125 200 µM 0.0473857921105541 0.475821184804604 no 1589 0.481102876276761 2223 79580 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0472277521666082 0.475885145008261 no 1590 0.481165854582345 2316 66535 A nucleotide analog. SGTC_873 0591-4978 488 µM 0.0467230320570314 0.47608941398301 no 1591 0.481366986731324 2317 3305145 SGTC_527 4476-4215 268 µM 0.0463162741407628 0.476254040535824 no 1592 0.481529084170208 2177 4418754 SGTC_409 arachidonic acid 100 µM 0.0450773134345231 0.476755508197872 no 1593 0.482022842146955 2341 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3355 9151058 44.0485 µM 0.0450131162875376 0.476781492915851 no 1594 0.482048427133112 2333 17015728 SGTC_1616 st002734 56.1 µM 0.0437166566669244 0.477306274560001 no 1595 0.482565130904831 2235 4026101 SGTC_438 sphingosine 6.67 µM 0.0422730391040832 0.477890669147771 no 1596 0.483140518872899 2305 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2071 5230951 39.92 µM 0.0420094715114798 0.477997369801229 no 1597 0.483245573804842 2312 1799272 SGTC_2566 crystal violet carbinol 226 nM 0.0403912963339803 0.478652493528938 no 1598 0.48389058455382 2188 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_642 0335-0876 158 µM 0.0392219961610746 0.479125924685353 no 1599 0.484356698363641 2307 6812350 SGTC_296 1222-0039 74.9 µM 0.0389939580794547 0.479218257152767 no 1600 0.484447602852955 2304 5984176 SGTC_1571 st070080 73.4 µM 0.0386994588661058 0.479337501337589 no 1601 0.484565002424958 2327 4315245 SGTC_481 bay k-8644 50 µM 0.0382716321764806 0.479510733767416 no 1602 0.484735554226743 2307 2303 A calcium channel antagonist. SGTC_2796 7949634 45.45 µM 0.0379563661226152 0.479638391452896 no 1603 0.484861235864116 2324 2971588 SGTC_546 peri-Naphthalide 147 µM 0.0374521599090678 0.479842559216429 no 1604 0.485062242111432 2309 223824 A penicillin ester. SGTC_1581 himbacine 57.9 µM 0.0367499066487857 0.48012693079136 no 1605 0.485342207871868 2324 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2131 toluylene red 5.2905 µM 0.0353798398278935 0.480681756857555 no 1606 0.485888430066671 2303 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2386 9075165 157.42 µM 0.0342092112033295 0.481155847569174 no 1607 0.486355160681685 2326 16452277 SGTC_2311 7694451 200 µM 0.0342034043425315 0.481158199345927 no 1608 0.486357475929075 2310 2163142 SGTC_2452 5863136 48.41 µM 0.033919911521783 0.481273014642923 no 1609 0.486470507612577 2333 2184096 SGTC_2870 9038528 12.99 µM 0.0335822321739391 0.481409777644466 no 1610 0.486605145473829 2257 6463316 SGTC_1775 st081588 35.1725 µM 0.0329284579609861 0.481674567953305 no 1611 0.486865819462687 2333 1426443 YGL099W LSG1 SGTC_2255 7941087 197.44 µM 0.0302198751276691 0.482771677521297 no 1612 0.487945848854919 2368 935561 SGTC_148 3253-0744 288.01 µM 0.0297118311265692 0.482977475167491 no 1613 0.488148438106914 2364 6893655 SGTC_1649 st011737 51.3 µM 0.0280683888628371 0.483643228900624 no 1614 0.488803803084111 2312 1761035 SGTC_233 rapamycin 362 pM 0.0256314528639896 0.484630508064972 no 1615 0.489775649274322 2361 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_109 0132-0036 33.701 µM 0.0244106868462492 0.4851251144499 no 1616 0.490262511998036 2345 67274 A color developer. SGTC_2525 harmine 47.85 µM 0.0243584856625408 0.48514626483243 no 1617 0.490283331066789 2348 5280953 A monoamine oxidase inhibitor SGTC_843 0310-0051 143 µM 0.0235217144624267 0.485485305546349 no 1618 0.490617058819674 2342 2065037 SGTC_2352 9027995 87.8 µM 0.0232529703809045 0.485594196791457 no 1619 0.490724242878956 2325 2997347 SGTC_2516 gossypol 71.55 µM 0.0222489996706117 0.486001000752236 no 1620 0.491124665582491 2356 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_349 k015-0014 24 µM 0.0221821231791708 0.486028099297659 no 1621 0.491151338859628 2359 2196908 SGTC_1082 camptothecin 424.86 nM 0.0208961024059642 0.486549210991105 no 1622 0.491664267887947 2377 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_357 1325-0123 420 µM 0.0208174351061919 0.486581088718886 no 1623 0.491695644774612 2365 1098503 SGTC_3187 9109394 49.47 µM 0.0206872959791783 0.486633824156329 no 1624 0.491747551596359 2363 17098090 SGTC_2935 9038016 29.96 µM 0.0203162555010574 0.486784179771567 no 1625 0.491895544224366 2373 6463195 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0201117989466282 0.486867031889387 no 1626 0.491977093925704 2351 165506 SGTC_3279 9140807 49.47 µM 0.0191555806819584 0.487254528564074 no 1627 0.49235849628733 2359 45595718 SGTC_2429 5902844 64.44 µM 0.0176564230592169 0.487862069376684 no 1628 0.492956472292035 2374 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1198 1612-1005 86.7 µM 0.0175019454031624 0.487924673812036 no 1629 0.493018090438758 2352 6998509 SGTC_1547 harmine 94.2 µM 0.0171327074321315 0.488074314355956 no 1630 0.493165372990172 2383 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2880 9042983 58.44 µM 0.0169227209949848 0.488159416008967 no 1631 0.493249133314365 2356 6464714 SGTC_2342 7990637 118.86 µM 0.0166263631598627 0.488279522499827 no 1632 0.493367346351617 2360 2033102 YER133W GLC7 SGTC_2134 5324836 1.464 µM 0.0164846350989863 0.488336961749196 no 1633 0.493423879919353 2360 699272 SGTC_2239 6685329 187.64 µM 0.0160677017498593 0.488505937015043 no 1634 0.49359019022883 2283 805680 SGTC_562 3772-2733 112 µM 0.0156485775275424 0.488675802280155 no 1635 0.493757375577372 2371 2876874 YIL048W NEO1 SGTC_3249 9135183 49.47 µM 0.0155797990707652 0.488703677436849 no 1636 0.49378481086715 2363 4902779 SGTC_1807 st050092 58.9 µM 0.0152471501408278 0.488838497188242 no 1637 0.493917502826125 2367 5008496 SGTC_1667 st014849 34.6 µM 0.0152459730443791 0.488838974257587 no 1638 0.49391797236509 2374 5348460 SGTC_2190 6049624 200 µM 0.0143932557940945 0.489184579027727 no 1639 0.494258119965328 2365 2265554 SGTC_666 0272-0154 136 µM 0.0130405408390353 0.489732848525306 no 1640 0.494797724346534 2377 6870312 SGTC_1835 st008666 49.2 µM 0.0129963505756817 0.489750759633398 no 1641 0.494815352217118 2371 690455 SGTC_3281 9140613 49.47 µM 0.0123732519713679 0.490003314882004 no 1642 0.495063912593211 2353 16013766 SGTC_1189 1431-2119 7.28 µM 0.0110075349815836 0.490556883193202 no 1643 0.495608717571922 2380 3107275 SGTC_2688 kanamycin b 96.69 µM 0.0102200137393403 0.490876098808831 no 1644 0.495922875388265 2387 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_689 0833-0039 98 µM 0.00909374942127418 0.491332631401614 no 1645 0.496372168869902 2381 5374726 SGTC_1919 st067113 52.3 µM 0.00874539041973102 0.491473841467863 no 1646 0.496511138475441 2374 1268243 SGTC_3278 9139605 49.47 µM 0.00789584540086364 0.491818215680344 no 1647 0.496850046160433 2388 7958859 SGTC_3117 9124945 49.47 µM 0.00705593667847799 0.492158689689721 no 1648 0.497185111888256 2393 17592065 SGTC_2015 5119600 184 µM 0.006581070434008 0.492351188882241 no 1649 0.497374551705163 2386 2828786 SGTC_2056 5235370 200 µM 0.00657453099124791 0.492353839825362 no 1650 0.497377160508931 2392 5511916 SGTC_115 0527-0192 112.043 µM 0.00641513804971676 0.492418454245658 no 1651 0.497440747751278 2377 4233931 SGTC_667 1498-1044 59 µM 0.00602734265032753 0.492575658865648 no 1652 0.497595452737403 2382 6739982 SGTC_3215 9129942 49.47 µM 0.00540153922721655 0.492829349673888 no 1653 0.497845108101767 2394 17682944 SGTC_1766 st045414 44.774 µM 0.00371850548311768 0.493511639032345 no 1654 0.498516534361597 2401 253960 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.00293935467542253 0.493827507521933 no 1655 0.49882736883143 2376 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2995 9067767 71.4286 µM 0.00288570203018192 0.493849258500794 no 1656 0.498848773049285 2395 11673567 SGTC_1007 4101-0031 70 µM 0.00259350341997416 0.493967717206736 no 1657 0.498965342991302 2403 1146276 SGTC_966 1300-0360 30.2 µM 0.000373957471337014 0.494867548304897 no 1658 0.499850812557089 2402 70588 SGTC_301 4119-0100 24.5 µM 0 0.495019157937108 no 1659 0.5 2405 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3089 9117425 49.47 µM -0.000401368881502924 0.495181881488002 no 1660 0.49983987698743 2409 9401657 SGTC_1734 st037168 69.4 µM -0.000800223354956131 0.495343586438178 no 1661 0.499680757104015 2410 708907 SGTC_975 1335-0046 28.5 µM -0.00209983080334089 0.495870482921594 no 1662 0.499162289326476 2411 16486740 SGTC_831 k061-1017 217 µM -0.0023203792163562 0.495959900033979 no 1663 0.499074303454714 2411 1240153 SGTC_1111 tnp00062 510.699 nM -0.00423281958687968 0.496735270230798 no 1664 0.498311354343994 2416 676306 SGTC_2698 st077697 67.5 µM -0.00480323078994897 0.496966537398073 no 1665 0.4980837955235 2424 3154499 SGTC_482 fipronil 114 µM -0.00485120715624021 0.496985988954068 no 1666 0.498064655945525 2414 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_120 rhodamine 6G 52.259 µM -0.00514533250863043 0.49710523940247 no 1667 0.497947318372856 2414 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2650 prasterone 100 µM -0.00702853093472832 0.497868770747585 no 1668 0.497196044927059 2416 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1285 0929-0069 65.5 µM -0.00748754146804531 0.498054875066041 no 1669 0.497012931042976 2424 1206237 SGTC_68 0986-0284 82.829 µM -0.00765595065786821 0.498123156129162 no 1670 0.496945747422718 2466 423278 YIL048W NEO1 SGTC_3302 9125395 16.351 µM -0.0079565087422308 0.498245016749365 no 1671 0.496825845748894 2434 17599668 SGTC_760 0568-0725 82.9 µM -0.00982147734788391 0.499001167425071 no 1672 0.496081860421575 2424 3916171 SGTC_1032 k061-1018 98.7 µM -0.0101279738538686 0.499125436710193 no 1673 0.495959592089725 2426 4005393 SGTC_2096 5468907 200 µM -0.0101687036477683 0.49914195064856 no 1674 0.49594334408957 2436 759785 SGTC_2585 alliin 100 µM -0.0102119906880736 0.499159501426819 no 1675 0.495926075955612 2433 87310 A garlic compound which reacts with lipids. SGTC_2975 9084847 53.72 µM -0.0106251255920651 0.499327007506521 no 1676 0.495761267920971 2458 27211724 SGTC_1158 4092-0494 91.8 µM -0.0110075099812317 0.499482045856705 no 1677 0.495608727545015 2468 1148199 SGTC_603 3794-0023 45.9 µM -0.0119792333626689 0.499876032923267 no 1678 0.495221091622286 2433 3802260 SGTC_496 calpeptin 138 µM -0.0125907339690146 0.499876032923267 no 1679 0.494977156587857 2459 73364 A calpain inhibitor. SGTC_2684 capsaicin 100 µM -0.0129667890246346 0.499723560660612 no 1680 0.494827144576032 2441 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1227 3909-8010 46.6 µM -0.0133594162322183 0.499564369229754 no 1681 0.49467052255282 2442 15982272 SGTC_1127 asiatic acid 681.4 nM -0.0133703726583599 0.499559926927294 no 1682 0.494666151961546 2439 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_76 0433-0009 400.328 µM -0.0134585200680575 0.499524187405333 no 1683 0.494630989396769 2485 2841569 SGTC_1006 4099-6547 255 µM -0.0136511561419811 0.499446082784771 no 1684 0.494554145781972 2443 3146833 SGTC_2918 7977171 22.06 µM -0.0137697347666802 0.499398004892072 no 1685 0.494506844201052 2429 2236483 SGTC_2919 7978188 46.38 µM -0.0138086676855226 0.499382219479842 no 1686 0.4944913136902 2423 2980291 SGTC_2623 humulene 100 µM -0.0143885439882798 0.49914710786302 no 1687 0.494259999509249 2450 6187145 An anti-inflammatory. SGTC_1350 1495-0454 146 µM -0.0145588431190441 0.499078059906976 no 1688 0.494192067101632 2444 1069057 SGTC_1337 1486-1011 40.3 µM -0.015071420644581 0.498870235002131 no 1689 0.493987600697156 2437 X1337 SGTC_3161 9100388 49.47 µM -0.0159837995770787 0.498500311140933 no 1690 0.493623658055002 2437 25236368 SGTC_913 3487-1245 167 µM -0.0170933983010042 0.498050426322122 no 1691 0.493181052768452 2442 4016153 SGTC_2658 polymyxin b sulfate 77.05 µM -0.017367681208009 0.497939219167901 no 1692 0.493071645962581 2445 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_374 0880-0231 82.3 µM -0.017826623282892 0.497753142889083 no 1693 0.492888582912086 2437 6833587 SGTC_1677 st019204 53.9 µM -0.0186932113103122 0.497401789510288 no 1694 0.492542921949807 2488 3945625 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0199257770639656 0.49690205600075 no 1695 0.492051291050863 2444 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1091 telmisartan 47.6 µM -0.0205685725082221 0.496641441825561 no 1696 0.491794905332716 2495 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1600 coumarin 106 71.1 µM -0.0214324648816145 0.49629118866766 no 1697 0.491450338139163 2554 100336 A hepatotoxic, DNA x-linker. SGTC_2555 cholic acid 100 µM -0.0221788579422447 0.495988576265545 no 1698 0.4911526411803 2543 6708657 Influences liver metabolism. SGTC_1940 st075990 51.1 µM -0.0223464106644471 0.495920645168307 no 1699 0.491085813877984 2596 1084979 SGTC_2700 st077718 96.8 µM -0.022404258980064 0.495897191685035 no 1700 0.491062741515415 2458 904970 SGTC_766 1391-0721 126 µM -0.0232834240251327 0.495540752975376 no 1701 0.490712096921092 2445 1020919 YIL115C NUP159 SGTC_108 0509-0257 621.132 µM -0.0233816005144892 0.495500949628197 no 1702 0.490672940828421 2452 536624 SGTC_1847 st056231 15 µM -0.0235849517431957 0.495418505800985 no 1703 0.490591837791454 2442 5393180 SGTC_3169 9102970 49.47 µM -0.0238809130769936 0.495298515801782 no 1704 0.490473799549793 2443 17027839 SGTC_1136 pergolide 1.05886 µM -0.023963845086749 0.495264893202453 no 1705 0.490440723930328 2457 47811 A dopamine receptor agonist. SGTC_579 4491-1009 110 µM -0.0255698034477872 0.494613806598835 no 1706 0.489800235774783 2444 1271041 SGTC_1630 st005209 31.3 µM -0.0261250894550169 0.494388686153846 no 1707 0.489578782699331 2446 3367314 SGTC_815 1582-0027 36.9 µM -0.0263559116079875 0.49429510825809 no 1708 0.48948672968111 2477 3128206 SGTC_1009 4106-0057 9.87 µM -0.0266510667592199 0.49417544949966 no 1709 0.489369021160981 2437 2928005 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0268827668419096 0.494081516407549 no 1710 0.489276619309237 2483 804 An inhibitor of viral and cellular DNA polymerases. SGTC_638 3970-0837 4.09 µM -0.0277501979278661 0.493729855768613 no 1711 0.488930693471872 2474 4118451 YLR208W SEC13 SGTC_2943 9068529 45.32 µM -0.0278687431591964 0.493681797347055 no 1712 0.488883419050747 2448 3270634 SGTC_1238 0333-0287 48.8 µM -0.0284007592992119 0.493466118313898 no 1713 0.488671259306791 2469 7226 SGTC_1627 st003713 25.6 µM -0.0289824618272124 0.493230298636186 no 1714 0.488439289076612 2481 16195070 YER133W GLC7 SGTC_1456 k015-0012 13 µM -0.0305417139686192 0.492598196489981 no 1715 0.487817512974549 2459 2989616 SGTC_2236 dapsone 200 µM -0.0308666671331024 0.492466466655932 no 1716 0.487687936511986 2463 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2863 9028737 58.44 µM -0.0308978648761788 0.492453819727097 no 1717 0.487675496346817 2470 6460917 SGTC_526 4469-0568 170 µM -0.0310923291329687 0.492374988054557 no 1718 0.487597953589336 2457 2901964 SGTC_2804 7954240 19.48 µM -0.0313305384532816 0.492278423470062 no 1719 0.487502968096601 2488 828705 SGTC_945 3381-0768 11.3 µM -0.0329321878416317 0.491629163643453 no 1720 0.48686433226218 2468 1126236 YIL048W NEO1 SGTC_342 k048-0088 23.3 µM -0.0348612445450933 0.490847212469881 no 1721 0.486095192094184 2459 6820570 SGTC_1401 3807-4679 7.6 µM -0.035175305836882 0.490719909666587 no 1722 0.485969976564932 2466 3291456 SGTC_1454 4239-0054 42.6 µM -0.0358537525334513 0.490444908735637 no 1723 0.485699486133982 2585 1340767 SGTC_1857 st056007 79.3 µM -0.036101089944874 0.490344654350224 no 1724 0.485600876622783 2475 619834 SGTC_2427 5545055 42.75 µM -0.0368874952726117 0.490025901225252 no 1725 0.485287355144806 2475 5372858 SGTC_2959 9079155 11 µM -0.0370456765390315 0.489961786485418 no 1726 0.485224293052525 2537 16189457 SGTC_3094 9117742 49.47 µM -0.0371803026185771 0.489907219443748 no 1727 0.485170621992682 2472 17149698 SGTC_316 k060-0003 58.6 µM -0.038018263258758 0.489567579040014 no 1728 0.484836560289774 2545 6152314 SGTC_690 glyoxal 20.3 µM -0.0386707868210425 0.489303104820013 no 1729 0.484576432360127 2483 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1546 5-methoxyflavanone 78.7 µM -0.0411637458887146 0.488292728297409 no 1730 0.483582677875626 2482 147795 SGTC_2553 4-methylesculetin 85.09 µM -0.0419730358802901 0.487964745327541 no 1731 0.483260096709123 2476 5319502 SGTC_2907 7721985 69.9 µM -0.0429355851777838 0.487574661192801 no 1732 0.482876441012483 2524 3267881 SGTC_2247 cerulenin 830 nM -0.0433328689139462 0.48741366084974 no 1733 0.482718095108542 2598 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2353 9059630 146.67 µM -0.0437422025884123 0.487247779381326 no 1734 0.482554949296271 2522 4779114 SGTC_1116 jasmonic acid  1.58368 µM -0.0448350966767483 0.486804897617492 no 1735 0.482119375053697 2541 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2321 7390090 138.78 µM -0.0450198080920334 0.486730047201813 no 1736 0.482045760192988 2538 649046 SGTC_2348 9022543 33.42 µM -0.0453472268774466 0.486597368776617 no 1737 0.48191527226351 2521 3162678 YDL140C RPO21 SGTC_332 4112-0506 40.9 µM -0.0461549695017691 0.486270057281883 no 1738 0.481593366664528 2491 2790355 SGTC_863 0466-0191 129 µM -0.0461883278393206 0.48625654009512 no 1739 0.481580072790911 2485 765160 YPR165W RHO1 SGTC_3026 9090633 49.47 µM -0.0463637986750531 0.486185437529844 no 1740 0.481510144970055 2490 25236842 SGTC_268 camptothecin 39.6153 µM -0.0474553182095888 0.485743152676511 no 1741 0.481075170544854 2489 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1237 0330-0133 46.1 µM -0.0477051752464277 0.48564191279171 no 1742 0.480975604775344 2500 X1237 YHR072W ERG7 SGTC_1179 1021-1431 9.29 µM -0.0483853250207028 0.485366326762643 no 1743 0.480704577271822 2541 2840958 SGTC_860 0443-0016 25.1 µM -0.0487355317993267 0.485224431182009 no 1744 0.480565029613422 2504 5337942 SGTC_1607 st000305 50.6 µM -0.0494005435617615 0.484954989162744 no 1745 0.48030004749644 2483 5457690 SGTC_2184 6075246 200 µM -0.0503021496750894 0.484589697486696 no 1746 0.479940805373662 2533 2267320 SGTC_2753 fluvastatin 17.09 µM -0.050824814604339 0.484377942237982 no 1747 0.479732558616167 2559 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2401 5128683 200 µM -0.0515198746228212 0.484096348761481 no 1748 0.479455632610857 2516 708373 SGTC_2809 7964133 12.99 µM -0.0531278350697999 0.483444937563725 no 1749 0.478815026793492 2519 1253665 SGTC_623 k072-0108 16.9 µM -0.0535745714102241 0.483263965101092 no 1750 0.478637058241373 2560 5382803 SGTC_1700 st030840 7.9285 µM -0.0542986681848391 0.482970641532697 no 1751 0.478348605312183 2581 5499307 SGTC_3206 9114350 49.47 µM -0.0543207227892277 0.482961707601026 no 1752 0.478339819764249 2489 17087243 SGTC_2695 st077686 51.995 µM -0.0552409879762893 0.482588932067657 no 1753 0.477973237543748 2527 2876092 SGTC_2567 aureobasidin a 60 nM -0.0567277900938754 0.48198669943476 no 1754 0.477381018180812 2660 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3047 9092122 49.47 µM -0.0567738410749785 0.481968047027634 no 1755 0.477362676058018 2529 17173831 SGTC_1531 st059297 52.4 µM -0.0569700158143848 0.481888589204325 no 1756 0.477284540124546 2564 7566702 SGTC_3216 9129716 49.47 µM -0.0571804057401916 0.481803374519008 no 1757 0.477200743286579 2530 8056934 SGTC_2741 miltefosine 3.04 µM -0.057346538040307 0.481736086182505 no 1758 0.47713457466392 2525 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2532 xanthone 78.9 µM -0.0591803108272656 0.480993390711933 no 1759 0.476404245917998 2548 7020 An insecticide. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0592715497221832 0.480956439790631 no 1760 0.476367910647937 2568 688751 SGTC_2997 9067075 71.4286 µM -0.0605700918074337 0.480430559962445 no 1761 0.475850796527683 2570 27209819 SGTC_2464 5717415 7.67 µM -0.0611892402217496 0.480179830957724 no 1762 0.475604249367938 2520 5285744 SGTC_2600 tangeritin 87.95 µM -0.0612478660083989 0.480156090390623 no 1763 0.475580904848195 2526 68077 A bioactive flavone. SGTC_3063 1327-0034 4 µM -0.0631333478380052 0.479392600762339 no 1764 0.474830159760843 2507 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1955 wogonin 32.4 µM -0.0641021939297206 0.479000314387491 no 1765 0.474444427468904 2732 5281703 A flavanone. SGTC_3272 9137413 49.47 µM -0.0641501514126028 0.478980896898596 no 1766 0.47442533449844 2517 17614870 SGTC_539 4859-0462 2.54 µM -0.0644571259103635 0.478856607282456 no 1767 0.474303122325231 2543 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0656373490368403 0.478378770948522 no 1768 0.473833276491636 2597 6708739 YPR165W RHO1 SGTC_389 tpck 16.7 µM -0.0663317395903346 0.478097647877208 no 1769 0.473556857161128 2558 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1629 st005085 44.9 µM -0.0677374017484954 0.477528600967378 no 1770 0.472997337691338 2528 24207091 SGTC_3090 9117696 49.47 µM -0.068341436741601 0.477284086624317 no 1771 0.472756919732888 2645 7923821 SGTC_2295 7971645 200 µM -0.0684188858576582 0.477252735713358 no 1772 0.472726094158059 2596 2978226 YKL099C UTP11 SGTC_1267 0828-0272 9.49 µM -0.0688271833653226 0.477087461803849 no 1773 0.47256359009684 2567 745334 SGTC_1218 1348-1416 30.7 µM -0.0695872594885565 0.476779802669712 no 1774 0.472261088906188 2518 6787668 SGTC_2354 9060492 162 µM -0.0703321978768684 0.476478284327183 no 1775 0.471964627876109 2578 6471895 SGTC_1811 st050069 61.5 µM -0.0713293959571769 0.476074683450155 no 1776 0.471567800108729 2538 3877702 SGTC_2046 4110841 106 µM -0.0715300086919726 0.475993491424948 no 1777 0.471487971118786 2548 44119630 YMR134W ERG29 SGTC_900 1112-0045 141 µM -0.0730782795729322 0.475366908715482 no 1778 0.470871912912774 2550 56211 YIL048W NEO1 SGTC_2639 lactacystin 53 µM -0.0731318690675026 0.475345222215896 no 1779 0.470850590850103 2578 3870 A proteasome inhibitor. SGTC_2395 5646831 180.19 µM -0.0731461118394757 0.475339458489018 no 1780 0.47084492398338 2622 6808628 SGTC_1455 4262-0120 131 µM -0.0737302103085584 0.475103091541617 no 1781 0.470612529926705 2727 1529587 SGTC_907 3448-6986 75.5 µM -0.0738776946924936 0.475043410463712 no 1782 0.470553852197608 2587 590582 SGTC_2932 9016711 44.54 µM -0.0742287195595256 0.474901366883848 no 1783 0.470414196988879 2560 7117328 SGTC_518 1021-0119 62.6 µM -0.0748080626636487 0.4746669404259 no 1784 0.47018371335893 2584 1097762 SGTC_1615 st002656 86.5 µM -0.075746129040184 0.47428737815751 no 1785 0.469810537858264 2521 1584458 SGTC_2954 9074818 52.69 µM -0.077004040293907 0.473778436316195 no 1786 0.469310165411972 2600 16648742 SGTC_537 1334-0398 209 µM -0.0788459208808859 0.473033302122756 no 1787 0.46857758906618 2535 5846986 SGTC_749 1000-0129 128 µM -0.0795602634387428 0.47274433954664 no 1788 0.46829350008561 2629 708470 SGTC_2817 7995342 71.43 µM -0.0796296919370844 0.472716255411179 no 1789 0.468265889721637 2550 18879975 SGTC_1967 st070177 51.4 µM -0.0801898128464534 0.472489688992431 no 1790 0.468043146120439 2625 5729214 SGTC_1050 3232-1156 69.3 µM -0.0804542917753169 0.472382711530176 no 1791 0.467937974107106 2588 700529 SGTC_3194 9111903 49.47 µM -0.083496442806992 0.471152355671167 no 1792 0.46672840287308 2656 17087251 SGTC_2137 5261020 140 µM -0.0843521426384653 0.470806328823613 no 1793 0.466388228127379 2559 763655 SGTC_2408 sulbentine 18.36 µM -0.0845804872558657 0.470713994822199 no 1794 0.466297456192272 2687 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1112 tnp00069 1.16933 µM -0.0845897237886587 0.470710259947762 no 1795 0.466293784507131 2674 145826 SGTC_256 clotrimazole 625 nM -0.0855247550601985 0.470332185099609 no 1796 0.465922107938151 2539 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3228 9131799 49.47 µM -0.0864941956751811 0.469940225259847 no 1797 0.465536784980933 2599 17015818 SGTC_1887 st057648 70.8 µM -0.0865525320072078 0.46991663990348 no 1798 0.465513599102375 2679 688672 SGTC_2825 7998094 58.44 µM -0.0865539678059048 0.469916059411955 no 1799 0.465513028443114 2631 2987815 SGTC_1770 st043884 66.3 µM -0.0871892777268557 0.469659210737493 no 1800 0.465260531017014 2569 670149 SGTC_2655 perillic acid 100 µM -0.0873606771890927 0.469589918015578 no 1801 0.465192412446318 2559 5702197 An apoptosis inducer. SGTC_1065 prochlorperazine maleate 2.48 µM -0.0887347443684305 0.469034448832095 no 1802 0.464646359712101 2561 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1349 flufenamic acid 69 µM -0.0888547739617363 0.468985929494973 no 1803 0.464598663235239 2560 3371 A non-steroidal anti-inflammatory. SGTC_3109 9122853 49.47 µM -0.0888766445402786 0.468977088841662 no 1804 0.464589972520385 2625 1234709 SGTC_418 lividomycin a 100 µM -0.0898990577873783 0.468563820118365 no 1805 0.464183714949284 2570 72394 An antibiotic. SGTC_2461 5755302 26.15 µM -0.0902368268115087 0.468427298231819 no 1806 0.464049510061396 2685 2788904 SGTC_3297 9117502 71.43 µM -0.0903485883570121 0.468382126472163 no 1807 0.464005105037077 2549 7453720 SGTC_1928 4'-methoxychalcone 40.3 µM -0.090381620257883 0.468368775722822 no 1808 0.4639919809096 2727 641818 SGTC_2108 5365811 200 µM -0.090744395761359 0.46822215239027 no 1809 0.463847846707101 2637 780283 SGTC_1692 fluoroquinolonic acid 71 µM -0.0909318862116174 0.468146375878674 no 1810 0.463773356803537 2679 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1553 gossypol 38.6 µM -0.0925577080843671 0.467489329180524 no 1811 0.463127471758922 2552 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2413 inermin 26.06 µM -0.0931495123525461 0.467250184011477 no 1812 0.462892391611701 2804 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3024 9090631 49.47 µM -0.0943476827858377 0.466766045565963 no 1813 0.462416486713232 2564 25236383 SGTC_1730 st033808 45.1 µM -0.0952038363671422 0.466420134153103 no 1814 0.462076461425105 2588 1045166 SGTC_327 1273-0057 3.96 µM -0.0952579383839722 0.46639827618468 no 1815 0.462054975491491 2620 3108138 SGTC_944 3370-0224 231 µM -0.0968537127957748 0.465753606954951 no 1816 0.461421283877468 2599 4580514 SGTC_646 4092-0839 27.3 µM -0.0971388270500525 0.465638434431516 no 1817 0.461308073558635 2662 877796 SGTC_996 3970-0799 1.8 µM -0.097343050213217 0.465555939808843 no 1818 0.461226984592602 2614 6615648 YGL040C HEM2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0988205659563159 0.464959151213467 no 1819 0.460640369573057 2654 23847180 SGTC_2331 7980721 200 µM -0.0993792095636606 0.464733527963366 no 1820 0.460418594701349 2685 2981221 SGTC_51 1013-0126 23.419 µM -0.100287118865236 0.464366868586184 no 1821 0.460058191795721 2590 1627850 SGTC_973 1325-0077 65.9 µM -0.100402452193578 0.464320293354944 no 1822 0.460012411518438 2667 2835149 SGTC_3289 9119912 71.43 µM -0.100702461659776 0.46419914237309 no 1823 0.459893328594179 2660 17014829 SGTC_2586 curcumin 80 µM -0.101793869761717 0.463758433821665 no 1824 0.459460145798298 2673 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2787 5284540 71.43 µM -0.102607000424563 0.463430122056229 no 1825 0.45913744331687 2656 736958 SGTC_1478 0453-0656 35.7 µM -0.103456823059789 0.463087022063382 no 1826 0.458800207879757 2597 5258496 SGTC_710 3448-4187 58 µM -0.103840432317972 0.462932155980019 no 1827 0.458647989770837 2603 3946412 SGTC_2840 9008771 71.43 µM -0.104473457596671 0.462676610977411 no 1828 0.458396815382588 2740 2992978 SGTC_1754 st042065 16.137 µM -0.104611249895385 0.46262098785367 no 1829 0.458342143782328 2641 1126236 YIL048W NEO1 SGTC_3021 9087658 49.47 µM -0.104796562093308 0.462546183350196 no 1830 0.458268619040688 2589 25237042 SGTC_42 0133-0086 60.653 µM -0.105088436220356 0.462428365951064 no 1831 0.458152817526981 2595 162923 Model of phenazepam hydroxylation. SGTC_2751 anetholtrithion 17.25 µM -0.106617576511631 0.461811169967239 no 1832 0.457546187013591 2692 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3254 9136651 49.47 µM -0.109786159802583 0.46053255165963 no 1833 0.456289483783603 2592 16454030 SGTC_1018 4259-0013 28.1 µM -0.110140932177052 0.460389415528706 no 1834 0.456148803214069 2751 6801262 SGTC_1462 k081-0014 26.5 µM -0.110432125509357 0.460271934773236 no 1835 0.456033338229183 2595 3270634 SGTC_294 k038-0071 157 µM -0.111738814989061 0.459744799105873 no 1836 0.455515251059885 2653 24152826 SGTC_542 3381-0244 89.3 µM -0.114398468682893 0.458672079485362 no 1837 0.454460963920823 2764 1112843 SGTC_957 1187-1561 14.1 µM -0.11458644101052 0.458596275793697 no 1838 0.454386463709438 2593 1538454 SGTC_1210 3013-0140 750 nM -0.116378211981679 0.457873783414161 no 1839 0.453676401184083 2742 905973 SGTC_2086 5274770 176.623 µM -0.117562520634278 0.457396313151634 no 1840 0.453207151574415 2663 689278 SGTC_2706 st078239 82.5 µM -0.117753714731465 0.457319236377794 no 1841 0.453131402299168 2625 15434492 SGTC_1208 2323-2347 50.3 µM -0.118994115649132 0.456819228151244 no 1842 0.45264000884524 2666 5412760 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.119089611210962 0.456780736512623 no 1843 0.452602180611157 2633 65057 A dermal irritant. YDR527W RBA50 SGTC_844 0330-0132 15.3 µM -0.119670459705458 0.456546621182277 no 1844 0.452372100947527 2706 2828079 SGTC_1280 0880-0253 10.1 µM -0.12065498996452 0.456149833388847 no 1845 0.451982155629214 2644 6836607 SGTC_610 4215-0184 155 µM -0.122871436258829 0.455256716403368 no 1846 0.451104452382206 2681 5605015 SGTC_3164 9100705 49.47 µM -0.123030542444034 0.455192613213471 no 1847 0.451041456157225 2772 17174235 SGTC_912 3474-0017 2.18 µM -0.124008753186432 0.454798522059475 no 1848 0.450654172261149 2768 3360550 SGTC_807 1315-0151 48 µM -0.124164758134802 0.454735676545796 no 1849 0.450592412599243 2648 4011080 SGTC_3354 9151612 71.43 µM -0.124260518565981 0.454697100679963 no 1850 0.450554503292569 2724 27261949 SGTC_406 estrone 100 µM -0.124898016087906 0.454440303857792 no 1851 0.450302144502999 2679 5870 A steroid. SGTC_2977 9011197 71.43 µM -0.12562708186747 0.454146644846648 no 1852 0.45001356227845 2851 2704722 SGTC_2502 avocadyne acetate 18.59 µM -0.126644055368243 0.453737061934125 no 1853 0.449611063254056 2602 3952079 SGTC_1906 st060206 94.7 µM -0.129952389297651 0.45240498333645 no 1854 0.448302047503443 2664 5133468 SGTC_3303 9125618 40.5795 µM -0.130445772886613 0.452206371249655 no 1855 0.448106877205761 2734 22695467 SGTC_287 k060-0039 29.6 µM -0.131423233557134 0.451812928784383 no 1856 0.447720255170821 2749 5861974 SGTC_2545 solidagenone 89.61 µM -0.133577818522612 0.450945843935725 no 1857 0.446868212614234 2614 6708572 An anti ulcer agent SGTC_2757 clomiphene 4.22 µM -0.135170765929443 0.450304933098801 no 1858 0.446238430170737 2768 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3025 9087895 49.47 µM -0.135445715161836 0.450194322335536 no 1859 0.446129740824908 2703 17173641 SGTC_2618 avocadyne 43.43 µM -0.135543314306951 0.450155059595462 no 1860 0.446091160176316 2674 3015189 SGTC_3345 9148410 3.559 µM -0.136219173218495 0.449883184629662 no 1861 0.445824009204681 2715 4903596 SGTC_830 4076-0286 57.8 µM -0.136265775907766 0.449864438824216 no 1862 0.445805589173752 2678 6866659 SGTC_751 0833-0568 350 µM -0.137963644374794 0.449181552454219 no 1863 0.445134575156081 2707 6954252 SGTC_3013 9080133 71.4286 µM -0.138345791462672 0.449027872746022 no 1864 0.444983568535753 2814 17050193 SGTC_2155 5570423 76 µM -0.1388217993579 0.448836457793883 no 1865 0.444795483690781 2660 797402 SGTC_1801 st050089 28.441 µM -0.139048792776751 0.448745182123773 no 1866 0.444705796228835 2640 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_260 nsc-65238 3.989 µM -0.139113479994105 0.448719171429527 no 1867 0.444680238154199 2758 3246252 SGTC_2947 9072639 7.68 µM -0.139910532270665 0.448398695275183 no 1868 0.444365339797622 2715 16488146 SGTC_1312 1218-2183 165 µM -0.140565292899303 0.448135456459826 no 1869 0.444106684098685 2642 6744073 SGTC_3077 9117319 49.47 µM -0.14100304970904 0.44795947421028 no 1870 0.443933766548081 2633 17154678 SGTC_1271 0832-2808 169 µM -0.141022562994404 0.447951629928919 no 1871 0.443926058887651 2779 3663794 SGTC_3163 9099914 49.47 µM -0.141120795419804 0.447912141101917 no 1872 0.443887257841245 2690 16268368 SGTC_460 trequinsin 123 µM -0.141551303098432 0.447739085773301 no 1873 0.443717216995028 2651 5537 A vasodilator. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.142560124634344 0.4473335990618 no 1874 0.443318795831821 2676 688669 SGTC_558 k064-0027 21.3 µM -0.143268488693554 0.447048911389016 no 1875 0.443039070723133 2760 5088526 SGTC_1003 4049-0218 100 µM -0.144595722120095 0.446515577035568 no 1876 0.442515037495537 2803 295161 SGTC_1363 1636-0063 10.4 µM -0.144736595452909 0.446458974276794 no 1877 0.442459422189321 2668 6072185 SGTC_2709 st078560 56 µM -0.146675457853198 0.445680052697963 no 1878 0.441694095430116 2745 17250903 SGTC_2708 st078559 56 µM -0.146698650771091 0.445670736402029 no 1879 0.441684941805904 2686 17250902 SGTC_1828 st055811 49 µM -0.147187566784165 0.445474352136016 no 1880 0.441491986991205 2770 5877589 SGTC_1926 methyl fluorone black 53.6 µM -0.147445121445236 0.445370904810121 no 1881 0.441390346459972 2662 72721 Reacts with homocysteine. SGTC_2020 4017018 200 µM -0.14937577193328 0.444595574244358 no 1882 0.440628564212699 2772 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1078 idebenone 36.1 µM -0.149437109848826 0.444570944988733 no 1883 0.440604365522674 2738 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2986 9022445 71.43 µM -0.14995294108595 0.444363829710432 no 1884 0.440400871464198 2830 6459286 SGTC_1160 4092-0570 10.5 µM -0.151592349981812 0.443705679451026 no 1885 0.439754233751292 2666 4994975 SGTC_851 0394-0702 453 µM -0.152898294216733 0.443181511521049 no 1886 0.439239240555711 2679 762646 SGTC_1115 galangin 695.678 nM -0.15350142977361 0.442939464001517 no 1887 0.439001431437226 2678 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.154179035271415 0.442667555959725 no 1888 0.438734285979247 2800 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1382 3002-2117 298 µM -0.154761838178943 0.442433711687646 no 1889 0.438504538690962 2758 1497314 SGTC_1719 st032227 49.2 µM -0.155458469548606 0.442154221119235 no 1890 0.438229946170068 2723 3125804 SGTC_430 0958-0115 16.4 µM -0.155701715824258 0.442056636768012 no 1891 0.438134072317469 2716 6833180 SGTC_3203 9113543 49.47 µM -0.15616011340033 0.441872748631832 no 1892 0.437953407927549 2862 17018012 SGTC_2653 dihydrofissinolide 100 µM -0.156407848705527 0.441773373772771 no 1893 0.437855775471331 2719 6857746 SGTC_484 loperamide 105 µM -0.158511164141019 0.440929812354696 no 1894 0.437027012082759 2658 3955 An opioid-receptor agonist. SGTC_2924 9010168 62.78 µM -0.15854931082832 0.440914515602784 no 1895 0.437011983792094 2777 2993929 SGTC_2308 7584454 197.62 µM -0.158733587693168 0.440840622158603 no 1896 0.436939387253884 2799 893577 SGTC_3275 9138069 49.47 µM -0.158785380187798 0.44081985418264 no 1897 0.436918983795252 2762 17617007 SGTC_700 3453-2283 142 µM -0.158991704027507 0.440737123183394 no 1898 0.436837704960093 2845 565664 SGTC_1239 0337-0584 35.4 µM -0.15994759229629 0.440353868312908 no 1899 0.436461178931495 2833 914301 YML130C ERO1 SGTC_3084 9116877 49.47 µM -0.162439018377243 0.439355216739441 no 1900 0.435480073308147 2673 27241325 SGTC_730 1436-0052 41.2 µM -0.163264839183402 0.439024283419514 no 1901 0.435154958338651 2687 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2191 5911152 200 µM -0.163778982685438 0.43881827086744 no 1902 0.434952568817779 2721 2875902 SGTC_2775 cyproheptadine 69.59 µM -0.163825731532617 0.438799539857364 no 1903 0.434934167257537 2704 2913 A selective serotonin reuptake inhibitor. SGTC_652 0437-0092 114 µM -0.163915206638069 0.438763689963015 no 1904 0.434898947925538 2703 3091274 SGTC_1079 idarubicin 2.36 µM -0.164294309176974 0.438611800933209 no 1905 0.434749730720726 2693 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_307 1501-1223 22.3 µM -0.16459175757132 0.438492633308896 no 1906 0.434632659619483 2763 2830329 SGTC_2298 7976326 193.81 µM -0.165245839152847 0.438230606310503 no 1907 0.434375243367934 2741 2235818 SGTC_2533 agelasine 13.65 µM -0.165985584185933 0.437934294916402 no 1908 0.434084147475665 2820 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1242 0402-0103 60.1 µM -0.166068143825309 0.437901227080527 no 1909 0.434051661777356 2694 432868 SGTC_3038 9091290 49.47 µM -0.166469420358532 0.437740508884556 no 1910 0.433893773195682 2811 25236843 SGTC_3261 9137475 49.47 µM -0.166886071106012 0.437573643918414 no 1911 0.433729846547736 2675 17027690 SGTC_2037 5169046 200 µM -0.167005611599077 0.437525771048767 no 1912 0.433682816760247 2812 5718022 SGTC_2271 7849410 118.62 µM -0.167142226637896 0.437471061385887 no 1913 0.433629070630821 2671 972430 SGTC_3146 9095609 49.47 µM -0.16802011102325 0.437119527204021 no 1914 0.433283728842666 2772 17173999 SGTC_1090 efavirenz 20.7 µM -0.1681518873039 0.437066763865131 no 1915 0.433231895135471 2750 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1054 3429-0080 167 µM -0.168158385302736 0.437064162089624 no 1916 0.433229339201636 2840 1162877 SGTC_896 0964-0007 44.5 µM -0.168411005524481 0.436963015966755 no 1917 0.433129975302892 2664 6756758 SGTC_3070 9117005 49.47 µM -0.168956396620725 0.436744661937793 no 1918 0.432915469347008 2690 8779016 SGTC_2486 5283202 22.39 µM -0.16896686883805 0.436740469445225 no 1919 0.432911350747289 2772 1377751 SGTC_2370 9071495 200 µM -0.168971401451612 0.436738654841401 no 1920 0.432909568126026 2763 21791103 SGTC_2156 5649887 115 µM -0.170044584263686 0.436309050287752 no 1921 0.43248753701117 2819 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_59 0330-0160 1.33 µM -0.170318815709028 0.436199285049833 no 1922 0.432379707325363 2720 4293482 SGTC_777 1315-0167 517 µM -0.170983835520754 0.435933121344121 no 1923 0.432118237903329 2797 4221767 SGTC_2827 7993847 71.43 µM -0.171771973625272 0.435617719057425 no 1924 0.43180839990259 2821 2985692 SGTC_658 3253-0951 102 µM -0.173529049556889 0.434914708555287 no 1925 0.431117797995604 2757 1184878 SGTC_2091 4-phenylthiadiazole 200 µM -0.175591177378421 0.434089908551888 no 1926 0.430307567045863 2738 270010 SGTC_564 3555-0129 330 µM -0.176560195597181 0.433702424140494 no 1927 0.429926931053232 2706 563260 SGTC_1913 st060213 96.1 µM -0.17657687252024 0.433695756042565 no 1928 0.429920380829843 2849 688959 SGTC_15 0266-0086 27.098 µM -0.176687141187768 0.43365166671328 no 1929 0.429877070903551 2764 1712902 YIL048W NEO1 SGTC_63 0099-0242 26.702 µM -0.177622853341222 0.433277569044244 no 1930 0.429509587783505 2829 3898502 YLR359W ADE13 SGTC_2159 5658611 73.75 µM -0.17798909300432 0.433131162705131 no 1931 0.429365770746458 2712 793844 SGTC_2183 6420625 130.508 µM -0.178004164918752 0.433125137820109 no 1932 0.429359852423603 2718 2897619 SGTC_150 3970-0969 77.2 µM -0.17820071967083 0.433046567952241 no 1933 0.429282672277101 2833 6615640 SGTC_1284 0929-0043 16 µM -0.178266568421016 0.43302024647566 no 1934 0.429256816390437 2789 1239883 SGTC_2330 7979373 200 µM -0.178369458697766 0.432979119122045 no 1935 0.429216416545146 2742 1863007 SGTC_1145 3546-0597 10.2 µM -0.179756730674806 0.432424669118179 no 1936 0.428671777057904 2768 875334 SGTC_2529 gangaleoidin 93.61 µM -0.179963071445988 0.43234221238851 no 1937 0.428590779767349 2734 4565183 SGTC_2316 5844804 197.44 µM -0.180074084045365 0.432297851381559 no 1938 0.428547203972817 2840 776813 SGTC_183 3914-0051 30.55 µM -0.180206546775273 0.432244919947346 no 1939 0.428495209494766 2841 1596232 SGTC_1260 0700-1617 7.75 µM -0.180863865130751 0.431982276878681 no 1940 0.428237216242768 2825 2853078 SGTC_929 2805-0021 398 µM -0.181283209066941 0.431814736357987 no 1941 0.428072642446343 2833 3098024 SGTC_2979 9012552 45.46 µM -0.181530777908891 0.431715830911491 no 1942 0.427975488586255 2822 17100905 SGTC_2794 7785382 27.27 µM -0.181812920223453 0.431603118345221 no 1943 0.427864772323374 2715 2205081 SGTC_1744 st037937 38.9 µM -0.181898806528404 0.431568808872518 no 1944 0.427831070562915 2895 1016152 SGTC_1943 st076331 65.2 µM -0.18251622630834 0.431322180021396 no 1945 0.427588810737013 2792 24208415 SGTC_1474 0330-0125 5.35 µM -0.183994084629278 0.430731957186291 no 1946 0.427009047741778 2771 X1474 SGTC_3185 9108267 49.47 µM -0.184195761116993 0.430651424172641 no 1947 0.426929942363771 2805 4910486 SGTC_1761 st044296 37 µM -0.185735504950922 0.43003667233345 no 1948 0.426326091913338 2705 1826700 SGTC_2762 leflunomide 42.06 µM -0.186053679100387 0.429909660512109 no 1949 0.42620133315544 2738 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_721 1187-1332 279 µM -0.186131183212901 0.429878722772123 no 1950 0.426170944259707 2700 25730 SGTC_1560 lithocholic acid 53.1 µM -0.187616029377577 0.429286091975267 no 1951 0.425588829879008 2730 9903 A bile acid which acts as a detergent. SGTC_2013 4024628 200 µM -0.187966988920541 0.429146040473038 no 1952 0.425451264458289 2889 5230760 SGTC_1089 terbinafine 2.25 µM -0.188124860370328 0.429083044285057 no 1953 0.425389386630355 2868 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2833 9001315 45.46 µM -0.188700375639013 0.428853409023859 no 1954 0.425163828580041 2778 2989378 SGTC_3340 9146634 11.102 µM -0.188919187036741 0.428766107815088 no 1955 0.42507807763908 2813 4907387 SGTC_48 0382-0018 55 µM -0.189699404447299 0.428454845650494 no 1956 0.424772343759209 2998 762596 SGTC_2274 7947094 46.08 µM -0.190990189906757 0.427939993807753 no 1957 0.424266639503089 2726 2971028 SGTC_1979 st071809 45.3 µM -0.191173177394453 0.427867016027271 no 1958 0.424194958688145 2877 4976333 SGTC_555 4296-0685 37 µM -0.191889593229049 0.427581323875539 no 1959 0.42391434468145 2721 2908540 YHR072W ERG7 SGTC_2482 5981709 142.65 µM -0.192244757984586 0.427439705418782 no 1960 0.423775243951904 2819 877755 SGTC_472 calcifediol 10 µM -0.193486981399617 0.426944454688033 no 1961 0.423288800377274 2816 5283731 A vitamin D metabolite. SGTC_3120 9124077 49.47 µM -0.19446887486043 0.426553073964492 no 1962 0.42290438237034 2708 18774327 YGL155W CDC43 SGTC_874 0599-0792 117 µM -0.194621076637509 0.426492413111177 no 1963 0.422844800894758 2889 765305 SGTC_2030 5175110 200 µM -0.194727689881678 0.426449922853276 no 1964 0.422803066727403 2882 2831986 SGTC_394 menadione 8.33 µM -0.19480937210544 0.426417369325729 no 1965 0.422771092490717 2752 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_428 3448-4153 16.5 µM -0.19514041076005 0.426285442744586 no 1966 0.422641513714323 2702 3834874 SGTC_2890 9046729 58.44 µM -0.195537022405718 0.426127394667899 no 1967 0.422486278662316 2794 903329 SGTC_2222 6885208 172.143 µM -0.195692042567986 0.426065623007251 no 1968 0.422425606551641 2787 609514 SGTC_185 k048-0037 25.491 µM -0.197112870926805 0.425499543108531 no 1969 0.421869605739347 2840 6827589 SGTC_935 2996-0153 430 µM -0.197228921132289 0.42545331368613 no 1970 0.42182419965155 2884 23738523 SGTC_1422 4031-0024 15.5 µM -0.197404512572152 0.425383367539392 no 1971 0.421755499290528 2754 782427 SGTC_2512 diallyl trisulfide 49.23 µM -0.198675796958863 0.42487702667937 no 1972 0.421258178910035 2742 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1043 0916-0009 19.3 µM -0.199882283819359 0.424396608664202 no 1973 0.420786323155069 2927 3101130 SGTC_1568 digitonin 820 nM -0.20008769690634 0.424314825201552 no 1974 0.420705997627172 2872 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_276 colchicine 750 µM -0.200334328110636 0.424216635403693 no 1975 0.420609558369071 2878 2833 A microtubule depolymerizer. SGTC_2807 7945238 51.95 µM -0.200613061612284 0.424105670573453 no 1976 0.420500572007998 2877 17148797 SGTC_2170 morpholine 200 µM -0.201195175954738 0.423873948129544 no 1977 0.420272981700899 2877 121171 Reacts with secondary amines. SGTC_1494 4358-1428 177 µM -0.201670831926594 0.423684623139055 no 1978 0.420087033401485 2891 1564571 SGTC_172 1112-0046 2.638 µM -0.201788026820876 0.423637978846089 no 1979 0.420041221111429 2817 2802135 YIL048W NEO1 SGTC_1860 st056228 74.6 µM -0.201912977282729 0.423588248967804 no 1980 0.419992378309988 2870 688679 SGTC_3356 9151811 4.48 µM -0.202162819711042 0.423488816142731 no 1981 0.419894719268824 2750 1859254 YPR165W RHO1 SGTC_2978 9011784 42.97 µM -0.202217074380634 0.423467224396718 no 1982 0.419873512717822 2900 2994934 SGTC_2125 5246583 200 µM -0.202361347490862 0.423409809105013 no 1983 0.419817121744081 2827 835267 SGTC_3317 9138495 8.753 µM -0.203053350358429 0.423134440522576 no 1984 0.419546666558373 2767 17020139 SGTC_2350 9023895 38.85 µM -0.203466532523304 0.422970040907626 no 1985 0.419385200859218 2914 2997209 SGTC_1625 st003711 30.1 µM -0.205240807456075 0.422264233639159 no 1986 0.418691994133815 2967 24207034 YER133W GLC7 SGTC_674 0498-0004 451 µM -0.205467420390214 0.42217410484975 no 1987 0.418603474911049 2822 4231473 SGTC_299 1273-0059 1.44 µM -0.206561759263887 0.421738920418724 no 1988 0.418176063900189 2872 2848077 SGTC_3041 9091929 49.47 µM -0.207210182107901 0.421481107932463 no 1989 0.417922857854226 2926 25236887 SGTC_500 h-89 112 µM -0.207536501094156 0.421351376446986 no 1990 0.41779544469868 2952 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1169 aniline yellow 25.8 µM -0.2084598813297 0.420984323395738 no 1991 0.417434952284188 2822 6051 A DNA damaging agent. SGTC_2681 menadione 3.18 µM -0.20990630794412 0.420409492232735 no 1992 0.416870399440997 2833 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2257 7960413 200 µM -0.211005119522354 0.419972921743718 no 1993 0.416441638247113 2795 2974689 YIL048W NEO1 SGTC_3299 9121982 43.1275 µM -0.211466114635898 0.419789792365299 no 1994 0.416261785461488 2810 17594604 YPL160W CDC60 SGTC_2285 7945142 200 µM -0.215166348443681 0.418320514393676 no 1995 0.414818813247482 2908 2970608 SGTC_3029 9088683 49.47 µM -0.216058796588424 0.417966313414419 no 1996 0.414470958341751 2923 25236615 SGTC_1678 st019265 80.2 µM -0.217003527842482 0.417591434447295 no 1997 0.414102797814263 3009 5367020 SGTC_1418 3966-3099 2.4 µM -0.217891295144337 0.417239227594108 no 1998 0.4137569048386 2871 740335 SGTC_366 0181-0206 4.31 µM -0.218084440743125 0.417162609087682 no 1999 0.413681660067634 2942 274874 SGTC_2800 7887935 81.82 µM -0.218180104130579 0.41712466175178 no 2000 0.413644393140127 2967 2961002 SGTC_171 k064-0041 9.68 µM -0.219796684453451 0.416483520737885 no 2001 0.413014750959977 2800 53325 SGTC_3328 9140624 29.0385 µM -0.222899030425244 0.415253743789909 no 2002 0.411807045507793 2965 4904392 SGTC_621 3584-0052 32.1 µM -0.225322184875206 0.414293776412339 no 2003 0.410864321170868 2839 2273927 SGTC_3277 9138724 49.47 µM -0.225417839428538 0.414255891952056 no 2004 0.41082711744388 2867 15943418 SGTC_137 0438-0332 85.389 µM -0.225787733155132 0.414109401217167 no 2005 0.410683259128858 2801 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1779 st039427 55 µM -0.226924440797271 0.413659300463692 no 2006 0.410241248377366 2955 1124498 SGTC_649 1123-0311 367 µM -0.227444557610806 0.413453388222172 no 2007 0.41003903802872 2905 693629 YIL048W NEO1 SGTC_1552 6-methylflavone 10.6 µM -0.227530571712431 0.41341933786285 no 2008 0.410005599879992 2818 689013 SGTC_1148 3909-7663 27.7 µM -0.228010749501452 0.413229262093011 no 2009 0.409818941864225 2950 4084526 SGTC_1851 st056236 18.9 µM -0.228406007092578 0.413072816779753 no 2010 0.409665309944404 2879 5393171 SGTC_2651 TUB2.036 5 µM -0.229090662006814 0.412801858955401 no 2011 0.409399225562284 2921 15992207 YFL037W TUB2 SGTC_3172 9105863 49.47 µM -0.229801943883458 0.412520407287995 no 2012 0.40912283707295 2846 2348785 SGTC_470 aa-861 153 µM -0.231369137255252 0.411900433448256 no 2013 0.408514019810252 2832 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1245 0418-0076 17.2 µM -0.232151366246284 0.411591069733078 no 2014 0.408210224983786 3007 6790114 SGTC_1356 1502-0781 85.8 µM -0.232324581567939 0.411522572236801 no 2015 0.408142960680658 2808 567702 SGTC_2733 amorolfine 100 µM -0.232688299830764 0.411378749683654 no 2016 0.408001727624869 2843 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.233623050061688 0.411009182650895 no 2017 0.40763881575978 2841 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1980 st071811 45.7 µM -0.235847017421754 0.410130223001775 no 2018 0.406775691226814 2976 4974850 SGTC_2871 9038510 12.99 µM -0.236267473109321 0.409964100480774 no 2019 0.406612562594998 2983 4945164 SGTC_499 genistein 192 µM -0.236684906837982 0.409799187923802 no 2020 0.406450622454528 2879 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2029 5175081 200 µM -0.236757646038513 0.409770452999768 no 2021 0.406422405488367 2813 1380876 SGTC_2835 9006588 71.43 µM -0.237407416233711 0.40951378902879 no 2022 0.406170368428053 3071 2345538 SGTC_372 0155-0182 15.9 µM -0.238573142303562 0.409053415978556 no 2023 0.40571829657476 2819 771486 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.240703140631679 0.408212553180255 no 2024 0.40489260232859 2817 23665772 A membrane-active detergent. SGTC_3086 9117350 49.47 µM -0.241339120683762 0.40796156806427 no 2025 0.404646146432633 2804 2679265 SGTC_591 4299-0174 154 µM -0.242747945875754 0.407405719594721 no 2026 0.404100331322733 2882 5509088 SGTC_74 000s-0487 160.283 µM -0.24377171473648 0.407001911010336 no 2027 0.403703813967435 2800 677548 SGTC_2136 5328288 199.296 µM -0.243973572349543 0.40692230328699 no 2028 0.403625643877315 2875 262395 SGTC_842 0271-0008 11.1 µM -0.244528467762423 0.406703485883588 no 2029 0.40341077846883 2949 1221709 SGTC_698 k064-0052 127 µM -0.245791402571225 0.40620556897715 no 2030 0.402921856349169 2815 5088751 SGTC_3028 9087778 49.47 µM -0.245860523994718 0.406178321959973 no 2031 0.402895101627111 2835 17217395 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.24825727770889 0.40523382602464 no 2032 0.401967675936405 2828 6708784 An antioxidant flavonoid SGTC_818 4072-2707 53.5 µM -0.249473407320773 0.404754792791022 no 2033 0.401497304310728 2811 882871 SGTC_1818 st052136 56.3 µM -0.249678177857137 0.404674147732087 no 2034 0.401418117682866 2936 674169 SGTC_110 0850-0284 111.64 µM -0.249928005801137 0.404575763136924 no 2035 0.401321512428869 2786 3906265 SGTC_3350 9150499 3.57 µM -0.252592949457253 0.403526659867255 no 2036 0.40029138945113 2834 4910996 YPR165W RHO1 SGTC_1682 st012968 530 nM -0.253739198516444 0.403075631135937 no 2037 0.399848524404783 2869 24207270 SGTC_1516 st013856 110 µM -0.255426088009965 0.402412104587 no 2038 0.399197011782569 2981 5281404 A mutagen and neurotoxin. SGTC_1451 4152-0210 104 µM -0.25576952108028 0.402277051889884 no 2039 0.399064404951896 3027 659563 SGTC_3250 9135583 49.47 µM -0.257095595294028 0.401755691918402 no 2040 0.398552488870947 2997 7699353 SGTC_778 3456-2434 196 µM -0.257909119067594 0.401435932974691 no 2041 0.398238523448858 3012 5539063 SGTC_3325 9138760 55.175 µM -0.258037626901117 0.401385428459864 no 2042 0.398188934093583 2901 43844959 SGTC_2151 5563267 85.4165 µM -0.258395044940204 0.401244969232006 no 2043 0.398051020176907 2892 5310824 SGTC_2716 st080858 38.6235 µM -0.259921140226973 0.400645383448177 no 2044 0.397462302012971 3001 5296050 SGTC_1381 2324-0066 62.1 µM -0.261487432512141 0.400030248054524 no 2045 0.396858319942638 2984 10885928 SGTC_2031 5180455 200 µM -0.262111335501078 0.399785289445871 no 2046 0.396617803878326 2869 29949 SGTC_1985 st071382 65.5 µM -0.263159397188925 0.399373885221355 no 2047 0.396213862210101 2887 6123237 SGTC_2167 5876490 200 µM -0.265657435255979 0.398393761184919 no 2048 0.395251523720314 3092 686534 SGTC_3078 9116413 49.47 µM -0.265701861444874 0.398376336015121 no 2049 0.395234414837962 2797 17177322 SGTC_1493 4348-0038 111 µM -0.26626078260276 0.398157129128765 no 2050 0.395019187071833 2919 800424 SGTC_3016 9080866 49.47 µM -0.267493639203447 0.39767372088628 no 2051 0.394544555492617 2899 17066299 SGTC_1253 0550-0034 176 µM -0.267895099424629 0.397516340518566 no 2052 0.394390032983493 2997 5969915 SGTC_1383 3049-0032 20.7 µM -0.270379955027171 0.396542599926394 no 2053 0.393433979790134 3036 712864 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.271301635968485 0.39618158436921 no 2054 0.393079524159129 2872 1241132 A phosphatase inhibitor. SGTC_125 0133-0007 11.75 µM -0.272088216081553 0.395873557183999 no 2055 0.392777095033662 3017 26541 SGTC_1294 1000-1494 117 µM -0.273460426691349 0.395336351042684 no 2056 0.392249654154759 2901 712797 YDL207W GLE1 SGTC_1217 1183-1422 255 µM -0.273602250580904 0.395280839789311 no 2057 0.392195152130524 3021 2849664 SGTC_3125 9127534 49.47 µM -0.273968027947423 0.395137680771299 no 2058 0.392054595964015 2923 1639235 SGTC_606 k015-0008 38.6 µM -0.273981138299029 0.395132549866074 no 2059 0.392049558350063 3027 1970475 SGTC_3088 9117578 49.47 µM -0.275282164866391 0.394623466907467 no 2060 0.391549732854521 2951 678341 SGTC_457 grayanotoxin iii 135 µM -0.275495665645116 0.394539942646883 no 2061 0.391467727674373 2929 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3251 9135047 49.47 µM -0.275769564279561 0.394432797065181 no 2062 0.391362530873977 2982 17682963 SGTC_3311 9131146 2.8755 µM -0.278377548053731 0.393412988912584 no 2063 0.390361276337831 2935 4900406 YPR165W RHO1 SGTC_837 0091-0265 12.5 µM -0.279269900396755 0.393064217006088 no 2064 0.390018851850113 2902 759367 SGTC_1884 5633444 25 µM -0.279555813991875 0.392952487101363 no 2065 0.38990915558268 3059 5724239 SGTC_739 1486-1183 203 µM -0.280486860959884 0.392588711806129 no 2066 0.389552002253247 3032 4346692 SGTC_3037 9091026 49.47 µM -0.281725881394432 0.392104751781282 no 2067 0.389076853753513 2997 25236398 YIL048W NEO1 SGTC_1491 4138-0063 26.5 µM -0.283234207085835 0.391515826681467 no 2068 0.388498654006033 2980 23883227 SGTC_1307 1187-1599 12.2 µM -0.284149610765029 0.391158528833232 no 2069 0.388147864609845 2902 1538471 SGTC_113 0099-0221 2.5 µM -0.285340373150057 0.390693891198096 no 2070 0.387691692305777 3098 89219 SGTC_31 0508-1974 57.237 µM -0.286826829630949 0.390114092208601 no 2071 0.38712245930924 3026 6810525 SGTC_1199 1638-0010 4.46 µM -0.287696415641132 0.38977501950668 no 2072 0.386789566992011 2894 3111136 SGTC_2038 4100038 30.985 µM -0.290415866439974 0.388715181966899 no 2073 0.385749053424904 3015 3596803 SGTC_474 dl-dihydrosphingosine 5 µM -0.290904286451551 0.388524920013302 no 2074 0.385562261455819 3059 3058739 A sphingolipid protein kinase C inhibitor. SGTC_965 1291-5240 308 µM -0.29092798726003 0.388515688143371 no 2075 0.38555319796335 3044 2834598 SGTC_2299 7976368 114.88 µM -0.292540214544989 0.387887846162672 no 2076 0.384936808577538 3062 2979718 SGTC_1175 0741-0056 27.6 µM -0.295415617667287 0.386768819789586 no 2077 0.383838202113976 3118 765927 SGTC_2051 5263410 176 µM -0.295986673790566 0.386546692410165 no 2078 0.383620129223936 2986 227584 SGTC_476 mead acid 10 µM -0.296350749507672 0.386405094930332 no 2079 0.383481116513782 2916 5312531 An omega 9 fatty acid. SGTC_2552 juarezic acid 87.02 µM -0.297074156064822 0.386123790264756 no 2080 0.38320494732219 2899 1549512 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.297764983837012 0.385855210090883 no 2081 0.382941270868647 2990 6857784 SGTC_1293 1000-1278 195 µM -0.29825602673736 0.385664335578928 no 2082 0.382753881652345 3066 678847 SGTC_718 1130-0073 349 µM -0.30063359149302 0.3847405387513 no 2083 0.381846956715885 3107 6740020 SGTC_2725 haloperidol 53.21 µM -0.300840402125824 0.384660213841998 no 2084 0.381768099119241 2925 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2694 st077685 81.9 µM -0.302583799959413 0.38398327810121 no 2085 0.381103530909128 2892 2838096 SGTC_569 4130-2812 160 µM -0.302740473488681 0.383922461370129 no 2086 0.381043825448126 2939 743552 SGTC_2436 5633522 8.09 µM -0.30490387620725 0.383082975614085 no 2087 0.380219681732695 3123 5724242 SGTC_473 2-arachidonoylglycerol 10 µM -0.305848586939885 0.382716562427154 no 2088 0.379859966431245 2890 5282280 An endocannabinoid. SGTC_2288 7946289 167.31 µM -0.305965902123059 0.382671068167153 no 2089 0.379815303850499 3152 1246052 SGTC_594 1487-1584 10.8 µM -0.30602579133608 0.382647844044485 no 2090 0.379792504292647 2955 5013332 SGTC_1439 4092-1168 46 µM -0.307488145106539 0.382080896716503 no 2091 0.379235922545318 3011 2886240 SGTC_2896 9052656 71.43 µM -0.308971348592505 0.381506124235751 no 2092 0.37867166085121 3060 6469436 SGTC_2876 9059903 25.97 µM -0.309600248840832 0.381262490974473 no 2093 0.378432483518264 2919 6916095 SGTC_1962 st076595 64.5 µM -0.309736706822861 0.381209633945733 no 2094 0.378380593267484 2954 279619 SGTC_2076 5212012 200 µM -0.312871663595866 0.379995919875111 no 2095 0.377189083357695 2932 604802 SGTC_378 3970-0959 8.33 µM -0.312999428226418 0.379946480130313 no 2096 0.37714054827526 3082 6615653 SGTC_2415 st077333 57.7 µM -0.313855945082323 0.379615093448067 no 2097 0.376815225781313 3207 2766255 SGTC_1759 st043059 70 µM -0.314496489086444 0.379367324504088 no 2098 0.376571991299105 2943 669426 SGTC_2128 5255449 168.493 µM -0.315050185655466 0.379153188945984 no 2099 0.376361774966511 2968 736008 SGTC_1570 verbenone 133 µM -0.315512498680907 0.378974423285091 no 2100 0.376186281379268 3150 29025 A natural terpanoid with antifungal properties. SGTC_385 1494-0393 12.4 µM -0.315521300443432 0.378971020099839 no 2101 0.37618294048673 3005 3090647 SGTC_1810 st050138 53 µM -0.315602510784037 0.378939620714032 no 2102 0.37615211584597 3084 3444541 SGTC_2471 5466956 24.79 µM -0.316232753997688 0.378695968944828 no 2103 0.375912924157333 2969 724419 SGTC_2844 9010103 25.97 µM -0.316866856746185 0.378450873729971 no 2104 0.375672315793037 3136 2480525 SGTC_1297 1068-0111 14.1 µM -0.317077120106961 0.378369612920992 no 2105 0.375592542666437 2963 767057 SGTC_27 0485-0001 32.618 µM -0.31872289671972 0.377733753150871 no 2106 0.374968325198176 2954 2054479 SGTC_544 k015-0020 52.4 µM -0.319021155163121 0.377618553865787 no 2107 0.374855235403151 3017 3008304 SGTC_1611 st001856 99.4 µM -0.319860183499255 0.377294546131736 no 2108 0.374537161183893 3003 647478 SGTC_2956 9076196 2.52 µM -0.323350834777328 0.375947490021904 no 2109 0.373214779665935 3100 16423868 SGTC_1671 st016596 74.5 µM -0.324195029319357 0.375621938178825 no 2110 0.37289519253321 3017 2829167 SGTC_1163 k060-0048 49.9 µM -0.324468698997116 0.375516420278364 no 2111 0.372791608032826 2972 6809982 SGTC_2601 securinine 100 µM -0.324732507168805 0.375414713459566 no 2112 0.372691764837849 2961 442872 A GABA receptor antagonist. SGTC_3105 9121040 49.47 µM -0.325672474903326 0.375052395089841 no 2113 0.372336085832589 3010 41448907 SGTC_447 ml7 120 µM -0.328343920789042 0.37402326687254 no 2114 0.371325819616334 3053 4216 Selective myosin light chain kinase inhibitor. SGTC_797 k781-0471 270 µM -0.328613134007921 0.373919606792769 no 2115 0.371224059718715 2982 23738129 SGTC_220 paclitaxel 373.376 µM -0.329092988638092 0.373734862219582 no 2116 0.371042701806466 3081 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1717 st033143 58.0435 µM -0.330425213687918 0.37322210625426 no 2117 0.37053934631566 3157 674616 SGTC_521 r062-0005 13.8 µM -0.330670484891536 0.373127729019339 no 2118 0.370446699454278 2962 2832033 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.330991623626281 0.373004170433888 no 2119 0.370325406334338 3100 688662 SGTC_1793 st048256 72.231 µM -0.332202211642818 0.372538512492012 no 2120 0.369868286928274 2974 672022 SGTC_1693 xanthone 101.9 µM -0.335215832175712 0.371380120494431 no 2121 0.368731139960518 3013 7020 An insecticide. SGTC_683 panaxydol 45 µM -0.335268674495158 0.371359819028004 no 2122 0.368711210876827 3003 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_983 1491-0821 12.2 µM -0.337624800297152 0.370454984641001 no 2123 0.367822975299228 3125 46495113 SGTC_3103 9120822 49.47 µM -0.337976849280677 0.370319846950378 no 2124 0.367690316941128 3214 17141819 SGTC_2761 levamisole 97.89 µM -0.338109066136833 0.370269098257967 no 2125 0.367640499339408 3151 26879 An alkaline phosphatase inhibitor. SGTC_206 4546-0025 72.014 µM -0.338199156825678 0.370234520112857 no 2126 0.367606555608452 3081 6620745 YIL048W NEO1 SGTC_1963 st076565 50.3 µM -0.338845555790638 0.369986453355227 no 2127 0.367363040335174 3008 4914280 SGTC_98 0074-0023 107.663 µM -0.340197041599685 0.369467972206544 no 2128 0.366854072964952 3069 3563821 SGTC_1097 itavastatin 7.23 µM -0.34094139664604 0.369182510692096 no 2129 0.366573849917604 3040 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_376 3970-0862 59.1 µM -0.341302713365323 0.36904397106541 no 2130 0.36643785272455 3125 3135186 SGTC_1010 4112-3296 15.2 µM -0.341389194149072 0.369010814271113 no 2131 0.36640530442349 3169 704384 SGTC_1684 st024538 14.6195 µM -0.341611478226923 0.368925594869791 no 2132 0.366321648986772 3011 6732859 SGTC_156 3474-0145 5.642 µM -0.342063435576112 0.368752343067151 no 2133 0.366151576821089 3082 2265471 SGTC_1976 st070609 63.5 µM -0.343067608564983 0.368367502291719 no 2134 0.365773799302819 2949 682556 SGTC_531 3788-1495 174 µM -0.343997211000729 0.368011357711951 no 2135 0.365424191772608 2953 2896655 SGTC_2378 9074213 121.43 µM -0.346083882499276 0.367212336138816 no 2136 0.36463983788282 3030 657714 SGTC_2790 5423970 71.43 µM -0.346134892857677 0.367192810598197 no 2137 0.364620670800779 3197 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2148 5546263 113.568 µM -0.346272624274457 0.36714009203405 no 2138 0.36456892007388 2996 792097 SGTC_1081 sertraline 6 µM -0.347608642758827 0.36662884300362 no 2139 0.364067057317128 3134 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1817 st052116 64.4 µM -0.347798463543613 0.366556224187698 no 2140 0.363995771814746 3154 4361398 SGTC_740 k014-0057 261 µM -0.349646159993533 0.365849609844206 no 2141 0.363302132090426 3111 4012779 SGTC_1507 4075-3230 155 µM -0.350789545033301 0.365412572894952 no 2142 0.362873120634805 3071 659771 SGTC_1867 st057372 64 µM -0.351224631203557 0.365246315425112 no 2143 0.362709916369777 3042 688837 SGTC_3122 9126309 49.47 µM -0.35162493800773 0.365093370400216 no 2144 0.362559780146843 3102 17591206 SGTC_2270 7924575 90.91 µM -0.351775238299815 0.365035950780789 no 2145 0.362503415043607 3164 1262135 SGTC_1324 1418-0026 34.4 µM -0.35244154454601 0.364781436498176 no 2146 0.362253575050619 3129 1372513 SGTC_2645 abamectin 100 µM -0.353423506528409 0.36440645731646 no 2147 0.361885482890848 3142 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1654 st012436 41.8 µM -0.353894510377361 0.364226642356767 no 2148 0.361708970623485 3128 4323132 SGTC_1114 scopoletin 1.73284 µM -0.354065216912739 0.36416147916356 no 2149 0.361645004315397 3166 5280460 A coumarin with genotoxic properties. SGTC_155 k072-0202 43.6 µM -0.354698029196261 0.363919952274734 no 2150 0.361407913770898 3104 5857737 SGTC_347 4534-1311 26.2 µM -0.355490224943824 0.363617669336026 no 2151 0.361111183353317 2995 2862016 SGTC_1166 k206-0078 225 µM -0.359268206906964 0.362177252407661 no 2152 0.359697228001838 3021 5404595 SGTC_3191 9110352 49.47 µM -0.359733809514391 0.361999868384765 no 2153 0.359523102995583 3088 17122424 SGTC_2929 9013348 24.6 µM -0.359887432338594 0.361941348077325 no 2154 0.359465657877193 3133 2995952 SGTC_2388 9080168 200 µM -0.361968467082632 0.361148927673204 no 2155 0.358687797270379 3018 15943073 SGTC_1706 st031321 9.9705 µM -0.362535654691846 0.360933056008467 no 2156 0.358475892218302 3144 6103185 SGTC_1433 4060-0023 7.6 µM -0.363086737860362 0.360723356117513 no 2157 0.358270045622142 3165 3840627 SGTC_1414 3917-0015 5.4 µM -0.363160954239359 0.360695118266593 no 2158 0.358242326656204 3143 6618702 SGTC_2057 5236571 38.335 µM -0.364174113176829 0.360309707528295 no 2159 0.357863998187964 3221 54684039 YBR257W POP4 SGTC_223 busulfan 5 mM -0.364297993484767 0.360262592567006 no 2160 0.357817749025457 3125 2478 A DNA alkylator. SGTC_77 0828-0286 12.516 µM -0.365117967257614 0.359950788370683 no 2161 0.357511674737849 3134 745345 SGTC_1125 tnp00248 1.32998 µM -0.365309975218503 0.359877788651424 no 2162 0.357440016531812 3220 24207736 SGTC_549 1661-1316 519 µM -0.365876438870135 0.359662453998168 no 2163 0.357228639129133 3193 2857282 SGTC_182 3448-4371 550.524 µM -0.366369923259529 0.359474897877952 no 2164 0.357044529831139 3086 3491403 SGTC_2644 guaiazulene 100 µM -0.366447642471241 0.359445362613655 no 2165 0.357015537357974 3122 3515 A coloring agent. SGTC_535 2293-4129 48.2 µM -0.368762709680148 0.358565964320904 no 2166 0.35615230103807 3209 396118 YIL048W NEO1 SGTC_622 1348-1566 26.3 µM -0.368897858602668 0.358514649941428 no 2167 0.356101929772893 3127 7340407 SGTC_1790 st045711 43.5 µM -0.369400160931884 0.358323954337134 no 2168 0.355914739023 3215 585119 SGTC_2362 9071156 126 µM -0.369710163115083 0.35820628178032 no 2169 0.355799229232284 3200 653133 SGTC_2062 5245942 200 µM -0.370410417705756 0.357940524369473 no 2170 0.35553835638596 3069 1376160 SGTC_2219 9098279 200 µM -0.371162960902731 0.35765499936131 no 2171 0.35525807936867 3164 902349 SGTC_306 1672-3436 11.6 µM -0.371336606553153 0.357589127169447 no 2172 0.355193417931691 3163 6797378 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.371643938274738 0.357472551785314 no 2173 0.355078985258529 3088 2374 Ca(2+)-ATPase inhibitor. SGTC_2963 9082507 9 µM -0.372215338639255 0.357255846683498 no 2174 0.354866263342362 3214 16459611 SGTC_2102 5377816 72.7585 µM -0.374102012564268 0.356540647849618 no 2175 0.354164210714102 3239 1379702 SGTC_1035 k081-0041 55.2 µM -0.374449729058138 0.356408890708091 no 2176 0.354034875483081 3208 731709 SGTC_254 nsc-64875 3.808 µM -0.375484243863979 0.356016992538507 no 2177 0.353650181135281 3218 56993 SGTC_2869 9037858 32.47 µM -0.375495386056559 0.356012772444938 no 2178 0.353646038615681 3016 27187042 SGTC_209 4077-0173 175.592 µM -0.377490265006956 0.355257498923065 no 2179 0.352904648801765 3141 15993494 SGTC_625 k213-0058 121 µM -0.378341714574717 0.354935307684519 no 2180 0.352588380324631 3134 3655420 SGTC_605 1315-0399 119 µM -0.379644232713064 0.354442631398973 no 2181 0.352104760907794 3216 24020461 SGTC_919 tnp00227 403.569 nM -0.379812916440219 0.354378844723601 no 2182 0.352042146832659 3082 1269246 A methoxyflavone. YNL221C POP1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.380599052415768 0.354081626319479 no 2183 0.351750392265962 3092 4620898 SGTC_617 3770-0098 35 µM -0.38073250503536 0.35403118003249 no 2184 0.351700873349168 3097 5962639 SGTC_1075 aripiprazole 15.2 µM -0.382827734961673 0.353239500716075 no 2185 0.350923747848465 3062 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2109 5483026 200 µM -0.383804424520689 0.352870676781222 no 2186 0.350561704237543 3119 759335 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.384943220096297 0.352440811848805 no 2187 0.350139741811033 3238 1273210 SGTC_832 4083-0019 164 µM -0.385435721937977 0.352254963874943 no 2188 0.349957310414315 3210 1990758 SGTC_1579 chlormadinone acetate 49.4 µM -0.387249504691324 0.35157082857964 no 2189 0.349285752065697 3205 45114258 A steroidal progestin. SGTC_2347 9049783 174.81 µM -0.387742388460318 0.351385002154945 no 2190 0.349103341812741 3236 6467988 YPL169C MEX67 SGTC_556 4058-0063 51.5 µM -0.387882201782094 0.351332296375068 no 2191 0.349051604957498 3133 6615692 SGTC_2865 9030313 51.95 µM -0.38877654271752 0.350995222089606 no 2192 0.348720727314033 3050 42562754 SGTC_1602 st001878 87.6 µM -0.389120968481999 0.350865440351314 no 2193 0.348593331424945 3238 595405 YLR310C CDC25 SGTC_2463 5473429 200 µM -0.38921290685671 0.35083080034969 no 2194 0.348559328228737 3138 5399405 SGTC_2085 5307070 144.047 µM -0.389395618206372 0.350761963119668 no 2195 0.348491756468722 3069 2840351 SGTC_1688 st021091 57.6 µM -0.389472489490942 0.350733003020495 no 2196 0.348463328757417 3205 3656366 SGTC_1642 st009582 77.7 µM -0.390994447022959 0.350159807202397 no 2197 0.34790067021903 3248 6739311 SGTC_3244 9134489 49.47 µM -0.39366930288237 0.349153237088159 no 2198 0.346912603882177 3162 16584271 SGTC_2980 9014342 25.29 µM -0.394065325967987 0.349004300305624 no 2199 0.346766404950919 3243 2996599 SGTC_3301 9125354 19.7965 µM -0.395574935477514 0.348436778235865 no 2200 0.346209315282127 3090 41905162 SGTC_3098 9119039 49.47 µM -0.39644485679569 0.348109894246111 no 2201 0.345888440073308 3140 17161528 SGTC_365 0121-0052 13.6 µM -0.396858547323796 0.347954484341147 no 2202 0.345735886878742 3213 3101739 SGTC_1915 st067105 30.6 µM -0.398623061872238 0.347291901377988 no 2203 0.345085483097504 3155 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2808 7946468 45.46 µM -0.399463362466747 0.346976528637721 no 2204 0.344775907172245 3148 2970879 SGTC_1330 1469-0054 61.8 µM -0.399481075412019 0.346969881941938 no 2205 0.34476938264705 3234 7102664 SGTC_33 0986-0033 35.816 µM -0.40057390004876 0.346559895997617 no 2206 0.344366932406726 3176 2848082 SGTC_2624 nerol 100 µM -0.400841705443894 0.346459453062265 no 2207 0.344268335620021 3091 637566 A natural product oil. SGTC_1786 berberine 21.6 µM -0.401375202627584 0.346259392098584 no 2208 0.344071951752289 3146 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2693 st077581 40.7 µM -0.401419202836795 0.346242893973611 no 2209 0.344055756858436 3236 25238761 SGTC_916 4466-0038 42 nM -0.401897196878058 0.346063686237074 no 2210 0.343879842888124 3321 5722064 YGL116W CDC20 SGTC_1258 0671-0043 57.1 µM -0.402710052477743 0.345759012626296 no 2211 0.343580768952214 3166 4298767 SGTC_1188 1403-0014 4.57 µM -0.40422205716552 0.34519255050718 no 2212 0.343024717619249 3131 9614867 SGTC_2568 diosmetin 100 µM -0.405322788408962 0.344780387106093 no 2213 0.342620128888247 3278 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_351 caspofungin 25 nM -0.407750192935869 0.343872108824176 no 2214 0.341728541753217 3148 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2687 chenodiol 100 µM -0.408122235988393 0.343732978411135 no 2215 0.341591967961853 3227 5702181 A cholesterol synthesis inhibitor. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.408826632257114 0.343469618099731 no 2216 0.341333446982832 3096 4000243 SGTC_1088 bifonazole 369 nM -0.409995246117439 0.343032863323006 no 2217 0.340904717410971 3201 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1594 piperine 70.1 µM -0.410166221851641 0.342968980851751 no 2218 0.340842008722962 3121 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_582 0987-0078 156 µM -0.410634755329003 0.342793943483971 no 2219 0.340670187465739 3267 1625765 SGTC_891 0929-0073 133 µM -0.412500599145563 0.342097226124211 no 2220 0.33998627081938 3238 5603632 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.413274064550324 0.34180856684243 no 2221 0.339702914718072 3231 140250 A respiratory chain inhibitor. SGTC_2868 9035608 32.47 µM -0.41414599136482 0.341483272379237 no 2222 0.339383596249462 3079 6462614 SGTC_2922 7999257 32.47 µM -0.41496949860114 0.341176150153324 no 2223 0.339082115936131 3215 2988377 SGTC_878 0828-0289 13.7 µM -0.415125596470494 0.341117946214937 no 2224 0.33902498119197 3147 745350 YLR208W SEC13 SGTC_805 3852-0218 479 µM -0.416571207604878 0.34057910350295 no 2225 0.338496036491963 3111 6615355 SGTC_2697 mebhydrolin 72.4 µM -0.418756045024555 0.339765336154917 no 2226 0.337697215766052 3309 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2074 5212007 75.395 µM -0.419824759053914 0.339367553094059 no 2227 0.337306738179869 3243 758611 SGTC_2546 rhodinyl acetate 100 µM -0.419933809854747 0.339326973653263 no 2228 0.337266903973647 3265 6708682 SGTC_2095 5432005 200 µM -0.421333925104189 0.338806135418067 no 2229 0.336755630404366 3131 783734 SGTC_688 0527-0193 473 µM -0.421400573768628 0.338781350008843 no 2230 0.336731300133368 3143 4007154 SGTC_1323 1348-1351 11.2 µM -0.424885065927735 0.337486506125916 no 2231 0.335460230928145 3153 6989654 SGTC_1854 st056233 32.9 µM -0.425219324445814 0.337362395814953 no 2232 0.335338399119186 3236 5393174 SGTC_2210 7115885 190.385 µM -0.425708183532483 0.337180914119463 no 2233 0.335160249093312 3177 2927039 SGTC_1742 st038235 28.8875 µM -0.426373258444369 0.33693407574045 no 2234 0.334917942027819 3242 564103 YBR002C RER2 SGTC_46 0329-0187a 2.197 µM -0.426383285436739 0.336930354822144 no 2235 0.334914289414296 3223 46494817 SGTC_632 0781-2353 4.65 µM -0.426943292993575 0.336722566865846 no 2236 0.334710315736948 3233 6811515 YHR007C ERG11 SGTC_2996 9066192 71.4286 µM -0.427625451839427 0.336469522622627 no 2237 0.334461916314238 3185 6472854 SGTC_892 0929-0076 29 µM -0.428162226088636 0.336270460294289 no 2238 0.334266507762907 3179 5751038 SGTC_3140 9094243 49.47 µM -0.428742857125946 0.336055185382062 no 2239 0.33405518404358 3264 19291112 SGTC_2937 9044753 11.33 µM -0.42881004749694 0.336030277332291 no 2240 0.334030733149277 3129 6465530 YGL099W LSG1 SGTC_1216 1165-0504 9.65 µM -0.428981577144371 0.335966693078777 no 2241 0.333968315893011 3278 6304004 SGTC_3004 9076122 71.4286 µM -0.429301952506554 0.335847945841924 no 2242 0.33385174804949 3284 44782551 SGTC_2718 lomofungin 53.02 µM -0.430324049282697 0.335469214900182 no 2243 0.333479967677286 3289 5351222 A RNA synthesis inhibitor. SGTC_169 k015-0017 16.025 µM -0.430357027257618 0.335456997919121 no 2244 0.333467974896239 3369 1840002 SGTC_799 1310-0557 151 µM -0.430526474285637 0.335394227520037 no 2245 0.333406356419395 3314 5354492 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.430693684737076 0.335332290148357 no 2246 0.333345555667666 3255 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3336 9143619 71.43 µM -0.431010638459396 0.335214897806254 no 2247 0.333230317564796 3294 45595730 SGTC_71 0417-1750 47.813 µM -0.432360859897637 0.334714987360432 no 2248 0.3327395802431 3313 6811472 SGTC_368 fentichlor 4.58 µM -0.432712938618781 0.334584680667839 no 2249 0.332611664451641 3203 7329 A pesticide. SGTC_3058 9093861 49.47 µM -0.43358340615372 0.334262600345267 no 2250 0.332295493442521 3306 17217477 SGTC_1459 k035-0031 35.7 µM -0.43403971706437 0.334093810181583 no 2251 0.332129799954634 3127 3877128 YMR208W ERG12 SGTC_2079 5212404 121 µM -0.434279262504215 0.33400521535254 no 2252 0.332042830465252 3307 758462 SGTC_126 0417-1624 672.48 µM -0.434448141027813 0.333942761931191 no 2253 0.331981522779505 3308 41912 YDL195W SEC31 SGTC_3327 9140648 26.9345 µM -0.434817578619556 0.333806155257545 no 2254 0.33184742215763 3279 8029710 SGTC_826 1683-5028 118 µM -0.43485589876204 0.333791986906348 no 2255 0.331833513720504 3240 722377 SGTC_2237 6667747 47.222 µM -0.435078591500035 0.333709653987717 no 2256 0.331752691157005 3103 729940 YDL015C TSC13 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.435090127614554 0.33370538912745 no 2257 0.331748504532615 3095 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1120 ficusin 1.78878 µM -0.435503011781734 0.333552761477732 no 2258 0.331598676678475 3277 6199 A DNA cross-linker. SGTC_1047 2043-3044 82 µM -0.436725493244585 0.333101017949568 no 2259 0.331155219318098 3181 669592 SGTC_2488 5268135 45.7 µM -0.436920676394261 0.333028914320594 no 2260 0.331084438176143 3285 1270356 YLR208W SEC13 SGTC_1265 0819-1001 68.8 µM -0.437563714804616 0.332791409813424 no 2261 0.330851289687085 3260 3106768 SGTC_1197 1601-0112 267 µM -0.437600560935431 0.332777802825238 no 2262 0.330837932253965 3149 7350313 SGTC_2185 6113692 200 µM -0.440502149538341 0.331706961694835 no 2263 0.329786727891774 3288 874150 SGTC_2207 7258803 200 µM -0.441322880822678 0.331404316881964 no 2264 0.329489631905064 3254 3666799 SGTC_1879 gemcitabine 100 µM -0.442547175775961 0.330953062476108 no 2265 0.329046650169214 3183 60750 A nucleoside analog which inhibits DNA replication. SGTC_822 1487-0950 154 µM -0.443299022400323 0.330676066148938 no 2266 0.328774731405685 3326 1958375 SGTC_162 k030-0015 37.8 µM -0.444159076749871 0.330359317469102 no 2267 0.328463788506404 3237 1809920 YMR134W ERG29 SGTC_1653 st012112 65 µM -0.444203040386012 0.330343129401629 no 2268 0.328447897141065 3317 720429 SGTC_2007 4011539 71.82 µM -0.444239113644024 0.330329846926373 no 2269 0.328434858111947 3163 45595301 SGTC_1046 2001-0062 216 µM -0.444953121568487 0.330066987247808 no 2270 0.328176816035966 3184 739778 SGTC_1951 sophoraflavanone G 9.2 µM -0.445796851212222 0.329756479053733 no 2271 0.327871998266855 3175 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1797 st048695 56.8 µM -0.447761525692497 0.329033897171994 no 2272 0.327162656558839 3283 592262 YIL048W NEO1 SGTC_899 1083-0020 478 µM -0.449120785589922 0.328534352363752 no 2273 0.326672263462068 3343 767123 SGTC_1673 st016611 27.3 µM -0.452050745013565 0.327458598731311 no 2274 0.325616212978951 3322 5226799 SGTC_1374 2889-5571 141 µM -0.452531685337891 0.327282154865696 no 2275 0.325443000163773 3231 2853281 SGTC_616 4092-0450 108 µM -0.453944735305574 0.326763968780679 no 2276 0.324934302068289 3248 787165 SGTC_1338 1486-1223 76 µM -0.457320477967819 0.325527387944342 no 2277 0.323720356442146 3245 3444526 SGTC_1278 0874-0585 172 µM -0.457618535485128 0.325418297339134 no 2278 0.323613262247815 3255 766306 SGTC_2263 7948595 193.29 µM -0.459081581327095 0.324883031961421 no 2279 0.323087791384533 3225 2971371 SGTC_870 0573-2213 57.6 µM -0.459552762625428 0.32471072391235 no 2280 0.322918635908359 3310 3916321 SGTC_2588 indole-3-carbinol 100 µM -0.46064619194392 0.324311008212143 no 2281 0.322526232715977 3325 3712 Induces cell cycle arrest. SGTC_1150 3909-7983 10.9 µM -0.460938025324778 0.32420435934897 no 2282 0.322421534737888 3224 23965914 SGTC_2150 5556613 200 µM -0.460958668464206 0.324196815976166 no 2283 0.322414129350131 3216 743190 SGTC_3141 9094609 49.47 µM -0.461183854726856 0.32411453357125 no 2284 0.322333352048574 3123 25236309 YDL196W YDL196W SGTC_1644 st010134 20.9 µM -0.461265517083054 0.324084696506401 no 2285 0.32230406074984 3316 3818134 SGTC_3186 9110464 49.47 µM -0.461783533918133 0.323895454450236 no 2286 0.3221182800851 3330 17018021 SGTC_1548 st061468 90.8 µM -0.461930021799072 0.323841947708758 no 2287 0.322065751981894 3280 390799 SGTC_1876 myriocin 605 nM -0.462237894580977 0.323729504747463 no 2288 0.321955365539338 3353 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1231 0242-0792 125 µM -0.462429721069341 0.323659452974839 no 2289 0.321886594931111 3188 3707635 SGTC_1477 0139-0234 16 µM -0.464211355823483 0.323009129009807 no 2290 0.321248163023633 3275 620880 SGTC_61 0978-8327 98.565 µM -0.465301787634627 0.322611371293277 no 2291 0.320857677402759 3320 6150059 YHR072W ERG7 SGTC_3176 9106582 49.47 µM -0.465448363078097 0.322557920308517 no 2292 0.320805203563052 3244 17018027 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.466136212158228 0.322307134584087 no 2293 0.320559002217909 3295 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_911 3456-4043 236 µM -0.466299022823823 0.322247786604182 no 2294 0.320500739057459 3281 914281 SGTC_1214 0358-0031 63.7 µM -0.466328530929817 0.322237030751589 no 2295 0.320490179807992 3405 4301366 SGTC_853 0419-0306 21 µM -0.466906215883415 0.322026491679789 no 2296 0.320283488952251 3203 762713 SGTC_423 5-fluorouracil 457 µM -0.472549469900525 0.319972802648941 no 2297 0.318267319980649 3125 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3319 9138450 16.7555 µM -0.473937640485048 0.319468461783739 no 2298 0.317772188321022 3213 2029690 SGTC_3232 9132874 49.47 µM -0.474079786159596 0.319416837189775 no 2299 0.317721506274046 3266 3784940 SGTC_967 1306-0166 352 µM -0.474409663582376 0.319297045498604 no 2300 0.31760390162433 3352 4437607 SGTC_2418 pentamidine 31.67 µM -0.474930671550965 0.319107885081675 no 2301 0.317418194485492 3328 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_24 0417-1663 219 µM -0.474985410767505 0.319088013851718 no 2302 0.317398686004622 3319 4329390 SGTC_1737 st035557 69.7 µM -0.475538105713614 0.318887405687098 no 2303 0.317201739763792 3258 5716916 SGTC_3159 9100096 49.47 µM -0.476044979179265 0.318703475683935 no 2304 0.317021166956603 3225 25236875 SGTC_257 daunorubicin 18.5 µM -0.476091219155842 0.318686698730029 no 2305 0.317004696211766 3344 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1956 st077085 54 µM -0.476360114018971 0.31858914469804 no 2306 0.316908922668403 3258 24208685 SGTC_2122 5258151 111.688 µM -0.476380793341695 0.318581642839113 no 2307 0.316901557725031 3244 2173356 SGTC_1034 k072-0165 12.7 µM -0.476578531182082 0.318509913037407 no 2308 0.316831137032626 3369 5835461 SGTC_636 0kpi-0074 126 µM -0.47784887033831 0.318049257245707 no 2309 0.316378887472012 3279 616434 SGTC_403 arphamenine a 50 µM -0.478865230392596 0.317680902984783 no 2310 0.316017253834138 3274 5487158 An arginine aminopeptidase inhibitor. SGTC_6 0844-0013 19.835 µM -0.48005281317406 0.317250721877589 no 2311 0.315594919952916 3369 1584900 SGTC_3073 9114972 49.47 µM -0.481908927193957 0.316578871424031 no 2312 0.314935322055967 3317 41905075 SGTC_790 1575-0012 79.1 µM -0.483408730393756 0.316036435010512 no 2313 0.314402775245475 3367 378741 YLR208W SEC13 SGTC_2736 butenafine 14.65 µM -0.483623263306732 0.315958876851331 no 2314 0.314326630903711 3245 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3231 9132313 49.47 µM -0.484580589936787 0.315612881904776 no 2315 0.313986942499459 3300 4905967 SGTC_1722 st034304 3.6505 µM -0.484678214020397 0.315577607889637 no 2316 0.313952311373941 3245 4036148 YLR033W RSC58 SGTC_2584 androsterone 48.74 µM -0.484726752726599 0.3155600702704 no 2317 0.313935093384005 3346 2754130 A steroid. SGTC_1870 st057514 26.5 µM -0.485042476663429 0.315446005548924 no 2318 0.313823107465812 3219 5393161 SGTC_1736 st036774 51 µM -0.486303831256996 0.314990478996813 no 2319 0.313375881623709 3443 1272247 SGTC_1628 st004252 77.7 µM -0.486661912649096 0.31486121243917 no 2320 0.313248970251889 3362 692968 SGTC_3121 9125696 49.47 µM -0.486915923491617 0.314769528858936 no 2321 0.313158957018915 3299 1235365 SGTC_3136 9095672 49.47 µM -0.486947172070605 0.314758250673814 no 2322 0.313147884301376 3268 17217380 SGTC_3158 9100007 49.47 µM -0.487157416195414 0.314682374206699 no 2323 0.313073390132559 3241 19297233 SGTC_127 0180-0333 59.125 µM -0.487733706064951 0.314474433064875 no 2324 0.31286923694151 3348 771601 SGTC_2722 naftopidil 47.16 µM -0.488207788743728 0.314303415182735 no 2325 0.312701334103187 3346 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2233 sulbentine 40.3845 µM -0.488499173495826 0.314198322480966 no 2326 0.312598155503015 3307 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_352 k048-0007 5.11 µM -0.489419662027962 0.313866432132754 no 2327 0.312272309356709 3339 6811911 SGTC_1711 st032263 62.8 µM -0.48964244360491 0.313786128864544 no 2328 0.312193468373332 3301 3958979 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.490335435517148 0.313536391207297 no 2329 0.311948277937036 3343 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2005 4024620 188 µM -0.491467328329965 0.313128667988518 no 2330 0.311547977279404 3322 236743 SGTC_1144 3486-0183 12.5 µM -0.492882083382633 0.312619375067394 no 2331 0.311047953767815 3305 6744069 SGTC_398 bronopol 33.3 µM -0.493042227696162 0.312561747766 no 2332 0.310991375158252 3210 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1990 st072050 59.8 µM -0.494033050091413 0.312205306154095 no 2333 0.310641419296969 3250 17233948 SGTC_1747 st037496 66.6 µM -0.494246015079015 0.312128716380068 no 2334 0.310566222976391 3251 723305 SGTC_255 tunicamycin 200.472 nM -0.495020123869883 0.311850387778997 no 2335 0.310292957727369 3305 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1030 k029-0042 36.7 µM -0.495279838658006 0.31175703212664 no 2336 0.310201300230225 3303 6080581 SGTC_2864 9034755 47.6 µM -0.495402755511909 0.311712853325398 no 2337 0.310157925018987 3379 4930451 SGTC_1992 st073643 23.3 µM -0.496197664760324 0.3114272123265 no 2338 0.309877479219535 3292 3161292 SGTC_1836 st055642 81 µM -0.496625330367819 0.31127358281288 no 2339 0.309726643563586 3265 8571 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.497891594358608 0.310818897978269 no 2340 0.309280226099747 3378 756377 SGTC_123 0083-0120 66.675 µM -0.498045006338376 0.310763831034946 no 2341 0.309226160277605 3288 16001701 SGTC_2258 7960471 200 µM -0.498348623153371 0.310654860842774 no 2342 0.309119171081311 3301 2974708 SGTC_1523 st012844 44.7 µM -0.499125625397365 0.31037606498 no 2343 0.308845442967957 3385 4274103 SGTC_2153 5569715 200 µM -0.499138969863756 0.310371277808295 no 2344 0.308840742807077 3335 2054701 SGTC_2616 abietic acid 100 µM -0.499604816143873 0.310204181027517 no 2345 0.308676683002245 3407 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2234 tolnaftate 200 µM -0.500298833751794 0.30995531297663 no 2346 0.308432337584688 3305 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1396 3511-0007 98.6 µM -0.50049663791083 0.309884398240582 no 2347 0.308362711452176 3342 X1396 SGTC_2287 7945887 168.79 µM -0.500600046090373 0.309847328206678 no 2348 0.308326315003359 3329 1245853 SGTC_2132 5317594 122.667 µM -0.504205594353166 0.308556012987555 no 2349 0.307058454789967 3250 794577 SGTC_1709 st033179 39.1045 µM -0.504286027514854 0.30852723301868 no 2350 0.307030197369412 3307 573381 SGTC_2053 5265679 138 µM -0.504708577751715 0.308376058702827 no 2351 0.306881767729507 3278 764595 SGTC_431 k089-0097 107 µM -0.508544637568895 0.307005133797595 no 2352 0.305535721600561 3323 5499420 SGTC_134 0269-0018 6.916 µM -0.50859023610002 0.306988854032889 no 2353 0.305519737147732 3321 4378915 SGTC_1174 0739-0097 51.1 µM -0.512435569110165 0.305617350075372 no 2354 0.304173101314101 3324 728447 SGTC_2892 9047358 58.44 µM -0.512522519453929 0.305586369154363 no 2355 0.304142681892419 3299 6466771 SGTC_686 1319-0111 510 µM -0.51464943401882 0.304828970800411 no 2356 0.303399007200096 3444 4562600 SGTC_281 1672-3440 14.9 µM -0.514715858140492 0.30480533048258 no 2357 0.303375795124983 3391 6833000 SGTC_3282 9108498 15.4605 µM -0.515364719396531 0.304574443898664 no 2358 0.303149090690784 3360 16459645 SGTC_2374 9071832 200 µM -0.516051358971568 0.304330199288291 no 2359 0.302909269506528 3397 17381698 SGTC_1655 st012546 55.1 µM -0.516721944000668 0.304091749654476 no 2360 0.302675137666578 3365 720985 YLR208W SEC13 SGTC_1937 st074714 47.2 µM -0.517548200067995 0.303798060372463 no 2361 0.302386765515004 3271 17250970 SGTC_2882 9058044 58.44 µM -0.519901617306095 0.302962242436559 no 2362 0.301566074056146 3360 18076804 SGTC_2273 7815444 169.05 µM -0.51993713086848 0.302949637653022 no 2363 0.301553697326705 3406 2824616 SGTC_227 fluconazole 33.516 µM -0.520684530967933 0.30268441835498 no 2364 0.301293276100839 3352 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2480 5767542 37.17 µM -0.521559009165229 0.30237423677831 no 2365 0.300988704909754 3320 2867358 SGTC_2813 7971799 71.43 µM -0.522718652157005 0.301963125935609 no 2366 0.300585028166258 3385 2234054 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.52305907495468 0.30184248863549 no 2367 0.300466571945276 3349 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3218 9131285 49.47 µM -0.523333053919759 0.301745413096866 no 2368 0.300371251365249 3475 17156417 SGTC_3190 9110366 49.47 µM -0.525459352222157 0.300992506085174 no 2369 0.2996319515801 3360 17123768 SGTC_1612 st002233 45.4 µM -0.526406308351664 0.300657468501717 no 2370 0.299302966784691 3431 1035021 SGTC_2000 st075254 36.4 µM -0.52870689383235 0.299844212546185 no 2371 0.298504397086451 3386 17234175 SGTC_1109 tnp00067 928.257 nM -0.530095115758926 0.299353959003638 no 2372 0.298022992662623 3361 676295 SGTC_937 3122-0005 46.7 µM -0.531181774352776 0.298970457052396 no 2373 0.297646410741915 3422 759535 SGTC_1760 st045453 10.4495 µM -0.532911319128175 0.298360529318931 no 2374 0.297047484694303 3428 3323419 YIL048W NEO1 SGTC_678 1218-2179 85.9 µM -0.534358766981879 0.297850519454389 no 2375 0.296546670376873 3388 6820081 YOR116C RPO31 SGTC_1404 3909-7820 48.3 µM -0.535877205896604 0.297315923504034 no 2376 0.296021709455245 3431 23741373 SGTC_1480 1070-0044 41.2 µM -0.53667979446513 0.297033533806007 no 2377 0.295744407681946 3406 3124987 SGTC_2458 5808907 16.39 µM -0.536832784306354 0.296979718461638 no 2378 0.295691561824238 3481 2731747 SGTC_1470 k295-0292 231 µM -0.537191911530007 0.296853410246222 no 2379 0.295567528900894 3433 5045612 SGTC_1476 4112-3294 3.34 µM -0.537454490357412 0.296761074516672 no 2380 0.295476856349061 3459 704369 SGTC_469 w7 172 µM -0.537648600565369 0.296692824201149 no 2381 0.295409835301438 3417 45115570 A P450 inhibitor. SGTC_2679 rapamycin 1 nM -0.539227800672565 0.296137835264978 no 2382 0.294864839941023 3409 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2433 5607874 27.82 µM -0.539908967881021 0.29589859521523 no 2383 0.294629906500513 3373 2252428 SGTC_2016 5121758 140 µM -0.540107736195516 0.29582880039343 no 2384 0.294561367916758 3415 2795203 SGTC_2377 9073351 62.6 µM -0.540122291286269 0.295823689866119 no 2385 0.294556349371186 3334 7337946 YHR072W ERG7 SGTC_222 nsc-310342 10.666 µM -0.541032861997062 0.295504054452842 no 2386 0.294242466171305 3409 432556 SGTC_941 3237-0776 460 µM -0.541446164916038 0.295359026162192 no 2387 0.294100047353123 3460 760008 SGTC_1975 st070967 30.8 µM -0.541935157270944 0.295187480701707 no 2388 0.293931588095031 3465 261391 SGTC_1159 4092-0538 61.2 µM -0.542007923478135 0.295161957204489 no 2389 0.293906523744178 3429 717301 SGTC_769 0302-0231 76 µM -0.542203066758923 0.2950935137043 no 2390 0.293839311438984 3444 571869 YER009W NTF2 SGTC_2846 9008642 19.48 µM -0.545391911108013 0.293976112795306 no 2391 0.292742001261435 3428 2992898 SGTC_337 1315-0038 354 µM -0.545570151914088 0.293913713320864 no 2392 0.292680723183041 3384 1626437 SGTC_2152 5568786 200 µM -0.545840070232248 0.293819230566421 no 2393 0.292587938291634 3401 5399883 SGTC_1866 st057638 64 µM -0.546177189642103 0.293701244344049 no 2394 0.292472072106244 3374 688802 SGTC_1437 4092-1038 11.6 µM -0.546953775830864 0.293429535482105 no 2395 0.292205244663233 3381 3977136 SGTC_505 gw-5074 63.9 µM -0.54776698767839 0.293145137059913 no 2396 0.291925954457706 3426 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2018 5133068 143 µM -0.548282961538653 0.292964755734996 no 2397 0.29174881242093 3402 785362 SGTC_3225 9130819 49.47 µM -0.54953131938716 0.292528550602772 no 2398 0.291320438636562 3460 4547121 SGTC_880 0833-0487 87.2 µM -0.549634393015863 0.292492547784329 no 2399 0.291285082061174 3429 76075 SGTC_118 0083-0097 135.343 µM -0.550183908428261 0.292300641083054 no 2400 0.291096619713003 3511 5207356 SGTC_192 3455-0609 60.9 µM -0.550232992733617 0.2922835022711 no 2401 0.291079788482245 3475 3769639 SGTC_102 gallobenzophenone 83.616 µM -0.550654318395879 0.292136406832295 no 2402 0.290935332703412 3506 70837 SGTC_1930 st074634 34.3 µM -0.550766267347794 0.292097328417028 no 2403 0.290896955503383 3371 684253 YOR116C RPO31 SGTC_662 k832-1615 104 µM -0.551271857360864 0.291920870642709 no 2404 0.290723663761082 3415 5878478 SGTC_3229 9132204 49.47 µM -0.553794667317275 0.291041118526222 no 2405 0.289859689134559 3412 17682924 SGTC_3099 9120367 49.47 µM -0.553807429851584 0.291036671136523 no 2406 0.289855321473942 3463 24824940 SGTC_1123 mangostin 811.285 nM -0.554598734067309 0.290760985564253 no 2407 0.289584577558978 3396 5281650 An antioxidant. SGTC_2824 7998404 51.95 µM -0.556514365496268 0.290094097353007 no 2408 0.288929638365943 3377 837851 SGTC_1331 1472-0049 76.2 µM -0.556960500693371 0.289938887416156 no 2409 0.288777208405468 3350 24051409 SGTC_2822 7994718 71.43 µM -0.559647835783485 0.289004791294338 no 2410 0.287859834813256 3419 1018011 SGTC_2444 5485484 36.41 µM -0.559840117040642 0.288938010179121 no 2411 0.287794248699871 3489 6790631 SGTC_107 0358-0022 2.6945 µM -0.560878186346871 0.288577604280162 no 2412 0.287440290765344 3429 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2238 6671620 73.2395 µM -0.560961653426671 0.288548634657748 no 2413 0.287411839342012 3426 729941 SGTC_661 1304-0007 33.6 µM -0.561171525397249 0.288475798680149 no 2414 0.287340306169914 3407 3117130 SGTC_665 3914-0008 307 µM -0.562960484555331 0.28785529316763 no 2415 0.286730896013674 3392 1069549 SGTC_2727 riluzole 51.77 µM -0.563867509028438 0.287540930184466 no 2416 0.286422151780516 3459 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1838 st055369 84.5 µM -0.564857041661686 0.287198156183873 no 2417 0.286085502460846 3436 676036 SGTC_1614 st002383 48.6 µM -0.565082457881891 0.287120099085741 no 2418 0.286008839811645 3482 1947235 SGTC_2678 equilin 100 µM -0.565689510923329 0.286909938804979 no 2419 0.285802433426101 3512 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2082 5219693 150 µM -0.565840053790773 0.286857832512543 no 2420 0.285751257744585 3452 2834649 SGTC_1355 1499-0035 1.68 µM -0.567677898224433 0.286222074809123 no 2421 0.285126850892012 3448 1548538 SGTC_2001 4023502 57.655 µM -0.568440207315596 0.285958568951154 no 2422 0.284868047670206 3437 108941 YCR052W RSC6 SGTC_568 1193-0097 7.48 µM -0.568759167120412 0.285848348981625 no 2423 0.284759794380869 3402 3646150 SGTC_723 4182-0001 115 µM -0.56887751210147 0.285807458747318 no 2424 0.284719633707512 3396 744821 YLR208W SEC13 SGTC_1465 k213-0056 144 µM -0.569099612936574 0.285730726583946 no 2425 0.28464427051716 3377 24048857 YMR208W ERG12 SGTC_2730 imipramine 71.33 µM -0.569387042842761 0.285631438857189 no 2426 0.284546754025665 3503 3696 A tricyclic antidepressant. SGTC_1360 1598-0022 39.8 µM -0.569958953182832 0.285433931094877 no 2427 0.284352769182844 3467 761525 SGTC_432 NS 1619 61.3 µM -0.570097639117911 0.285386046063346 no 2428 0.284305738168963 3487 4552 A K+/calcium channel activator. SGTC_835 0312-0010 67.2 µM -0.570406130439742 0.285279544898641 no 2429 0.28420113628414 3418 1626196 SGTC_391 gliotoxin 8.33 µM -0.570872417332345 0.285118603557217 no 2430 0.284043064704791 3535 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1172 0370-0043 85 µM -0.571568505169615 0.284878425788179 no 2431 0.283807168735238 3496 376585 SGTC_1314 1222-0010 41.1 µM -0.574393601548282 0.283904648125979 no 2432 0.282850740881187 3440 3526027 SGTC_2249 haloperidol 116.36 µM -0.574678094777399 0.28380667499857 no 2433 0.28275451241712 3475 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_422 cantharidin 155 µM -0.57483780353984 0.283751681955378 no 2434 0.28270049859182 3450 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2711 st079103 59.1 µM -0.575029717202598 0.283685606443538 no 2435 0.282635599563664 3415 54693780 SGTC_507 nimesulide 162 µM -0.575978918136081 0.283358906763745 no 2436 0.282314715675087 3542 4495 A COX2 inhibitor. SGTC_2838 9002687 71.43 µM -0.576157024712955 0.283297625453677 no 2437 0.2822545250609 3413 6457060 SGTC_3280 9140961 49.47 µM -0.57749754884207 0.282836594022489 no 2438 0.281801696991791 3370 4901226 SGTC_329 k048-0121 21.3 µM -0.577785655774719 0.282737555703584 no 2439 0.281704420411993 3482 6832902 SGTC_213 1246-0773 967 nM -0.578977068753613 0.282328178053775 no 2440 0.281302323076951 3433 6251622 SGTC_2451 5856223 45.7 µM -0.580897172571872 0.281669018015535 no 2441 0.280654879034799 3431 2179896 SGTC_2002 4023503 131 µM -0.584088312933782 0.280575163008944 no 2442 0.279580448676461 3571 4736863 YCR052W RSC6 SGTC_2244 6635614 200 µM -0.589647257502532 0.278674598676148 no 2443 0.277713580997388 3333 836499 SGTC_395 anisomycin 6.25 µM -0.590497599258906 0.27838442646826 no 2444 0.27742854740345 3458 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_764 1951-2361 146 µM -0.590584756964869 0.278354692931874 no 2445 0.277399340321425 3398 5438930 SGTC_2324 6149169 200 µM -0.590875363992806 0.27825556458053 no 2446 0.277301966987185 3405 2888231 SGTC_1699 st031318 29.054 µM -0.591481981511271 0.278048698034349 no 2447 0.277098762292365 3503 5340658 SGTC_1342 1486-1464 234 µM -0.591642507021653 0.277993968753761 no 2448 0.277045001663445 3524 3253938 SGTC_1247 0448-0043 5.84 µM -0.592170663611218 0.277813937098496 no 2449 0.276868155969406 3496 3089013 YGL099W LSG1 SGTC_1482 3346-2049 8.48 µM -0.592822392353323 0.277591862146821 no 2450 0.276650010130894 3494 3826804 SGTC_2652 actinonin 100 µM -0.594155834346397 0.277137765548079 no 2451 0.27620394472204 3487 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3239 9133757 49.47 µM -0.594898993387798 0.276884844509836 no 2452 0.275955495098245 3494 17036923 SGTC_358 0075-0058 9.45 µM -0.595596620115188 0.276647522493203 no 2453 0.275722367563513 3568 1069125 SGTC_1377 2944-0135 198 µM -0.599538835202407 0.275308317162168 no 2454 0.274406810463492 3528 1894137 SGTC_2093 5331342 194.4 µM -0.600806005159342 0.274878526959513 no 2455 0.273984601962766 3536 33839 SGTC_513 4245-1575 41.7 µM -0.601833636745577 0.274530224764838 no 2456 0.273642441205263 3495 719745 SGTC_1659 st012954 42.1 µM -0.602016924678841 0.274468124623421 no 2457 0.273581435781994 3530 24207262 SGTC_1916 st067606 49.2 µM -0.602045068157763 0.274458589890511 no 2458 0.273572069122896 3488 19590279 SGTC_491 tetrandrine 80.3 µM -0.602460395909925 0.274317899955481 no 2459 0.273433858985964 3520 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_675 1309-0189 238 µM -0.602704887878146 0.274235096332246 no 2460 0.27335251466644 3473 4246530 SGTC_1781 st038725 66.3 µM -0.604050747220777 0.273779506845067 no 2461 0.272904951792659 3484 4270275 YIL048W NEO1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.605343883155253 0.27334211775972 no 2462 0.27247526459124 3593 688664 SGTC_2610 ononetin 44.17 µM -0.60554214911535 0.273275087076508 no 2463 0.27240941388158 3494 259632 SGTC_3241 9133421 49.47 µM -0.606062057902928 0.273099352560901 no 2464 0.272236772457029 3521 17018221 SGTC_104 0074-0074 590.992 µM -0.60610411618587 0.273085138877917 no 2465 0.272222808919666 3423 3943124 SGTC_3160 9100216 49.47 µM -0.606523164073029 0.272943540813793 no 2466 0.272083702597332 3487 17191039 SGTC_3337 9144342 33.5465 µM -0.607134188808489 0.27273713822124 no 2467 0.271880931371415 3510 17682949 SGTC_538 2922-0838 53.3 µM -0.609553203160588 0.271920762345862 no 2468 0.271078909618646 3580 777039 SGTC_523 1934-0222 13.7 µM -0.609950893237333 0.271786665202473 no 2469 0.270947168907302 3523 1361595 SGTC_864 0469-0573 172 µM -0.610856042399716 0.271481580639442 no 2470 0.270647444023759 3470 689425 SGTC_486 niguldipine 82 µM -0.612248446724641 0.271012597844795 no 2471 0.270186696323916 3520 1236 A calcium channel blocker. SGTC_3214 9129694 49.47 µM -0.612301411384418 0.270994766530038 no 2472 0.270169178023601 3516 17158655 SGTC_1138 3761-0006 1.03 µM -0.613840563997181 0.270476844436271 no 2473 0.269660344610778 3532 12061087 SGTC_1085 doxorubicin 7.67 µM -0.615008286052639 0.270084238300109 no 2474 0.26927462414961 3562 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3143 9086658 49.47 µM -0.615205063528543 0.270018106763447 no 2475 0.269209652118838 3538 25236626 SGTC_1471 k673-0312 37 µM -0.616170899048202 0.269693633347336 no 2476 0.268890866400502 3538 24099884 SGTC_561 1550-0330 72.9 µM -0.616761863263492 0.269495194677024 no 2477 0.268695905013345 3472 6812934 SGTC_1540 guanosine 70.6 µM -0.618254535112252 0.268994299509232 no 2478 0.268203783235647 3511 6802 Guanosine is a purine nucleoside SGTC_1816 st051957 91.6 µM -0.61949736525774 0.268577600438437 no 2479 0.267794378541304 3540 674121 SGTC_2228 7354201 200 µM -0.62029412963504 0.268310630140659 no 2480 0.267532079539917 3573 753451 SGTC_43 0570-0105 72.5 µM -0.62040476873564 0.268273569069111 no 2481 0.267495666814782 3577 1114046 YDL195W SEC31 SGTC_1072 oxiconazole 14.9 nM -0.620544417312699 0.268226794293656 no 2482 0.267449710272864 3571 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_244 nsc-207895 1.295 µM -0.621034957373583 0.268062522239785 no 2483 0.267288311445257 3439 42640 SGTC_1093 fluphenazine 7.97 µM -0.62133605081052 0.267961717159926 no 2484 0.267189269209049 3588 6602611 An atypical antipsychotic. SGTC_2256 7954252 200 µM -0.623316654748014 0.267299093686649 no 2485 0.266538227689631 3506 2972920 SGTC_297 0986-0032 24 µM -0.623330631092196 0.267294420752351 no 2486 0.266533636397548 3509 2847425 SGTC_2724 maprotiline 69.64 µM -0.624123492953132 0.267029398101516 no 2487 0.266273243213453 3558 4011 A tricyclic antidepressant. SGTC_251 melphalan 456.522 µM -0.624785780649077 0.266808123037455 no 2488 0.26605583218408 3591 460612 A DNA alkylator. SGTC_2448 5185112 27.17 µM -0.624849045925263 0.266786990504717 no 2489 0.266035068620785 3548 5718189 SGTC_2416 tofa 880 nM -0.625623457259296 0.266528382054564 no 2490 0.265780974579909 3447 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2832 7992762 51.95 µM -0.626769235529157 0.26614599129401 no 2491 0.265405256190596 3408 2985177 SGTC_19 0279-0214 38.434 µM -0.627844440365288 0.265787406454374 no 2492 0.265052925227203 3603 3566274 YBR002C RER2 SGTC_3068 9116768 49.47 µM -0.628383304353539 0.265607785463188 no 2493 0.264876435770481 3548 41904888 SGTC_429 1112-0049 25.5 µM -0.628751861554636 0.265484968756856 no 2494 0.264755759828598 3495 2836170 SGTC_3126 9127922 49.47 µM -0.630024366707554 0.265061145203902 no 2495 0.264339321023278 3600 45595682 SGTC_2162 5663267 200 µM -0.630347249412008 0.264953659829011 no 2496 0.264233707808752 3571 6456493 SGTC_1448 4255-0083 152 µM -0.630918087124972 0.264763686189585 no 2497 0.264047042423325 3614 5399660 SGTC_759 3486-0358 89.3 µM -0.631094605563069 0.264704955231941 no 2498 0.263989334049062 3607 875103 SGTC_2218 6965428 192.983 µM -0.631979843716049 0.264410520042329 no 2499 0.263700024122908 3543 675684 SGTC_402 epigallocatechin gallate 10 µM -0.633226867810238 0.263996035809008 no 2500 0.263292751338749 3526 65064 An antioxidant. SGTC_2387 9077560 195.08 µM -0.633468373289981 0.263915802824072 no 2501 0.26321391381885 3524 5303272 SGTC_1802 st050112 57.9 µM -0.634096803691308 0.263707083855755 no 2502 0.263008824300979 3563 4662563 SGTC_371 0195-0006 7.36 µM -0.634200409333851 0.263672681667175 no 2503 0.262975020236977 3491 3928593 SGTC_195 4234-0266 16.654 µM -0.636302190206424 0.262975281299063 no 2504 0.262289738842359 3545 2303354 SGTC_788 1182-0090 188 µM -0.636515439679982 0.262904574857227 no 2505 0.26222026042981 3637 5715185 SGTC_2949 9072542 2.23 µM -0.636714249324739 0.262838664939051 no 2506 0.26215549512479 3581 16457352 SGTC_1135 dihydrocapsaicin 536.708 nM -0.638362921589353 0.262292418363555 no 2507 0.261618730743086 3551 107982 A Capsaicinoid. SGTC_1820 st053765 18.6 µM -0.638420282369185 0.262273423767733 no 2508 0.261600065738845 3563 3690829 SGTC_1453 4237-0541 195 µM -0.639420161918643 0.261942434316303 no 2509 0.261274818138919 3565 739892 SGTC_2455 5377712 9.75 µM -0.639837505258884 0.261804344814709 no 2510 0.261139123347772 3539 2243908 SGTC_3005 9076496 71.4286 µM -0.639975489529557 0.261758697146012 no 2511 0.261094267184369 3594 21368410 SGTC_3020 9089140 49.47 µM -0.640497298690492 0.261586110252101 no 2512 0.260924672383287 3584 17217859 SGTC_3188 9110789 49.47 µM -0.642416722023274 0.260951769405099 no 2513 0.260301322544117 3613 849217 SGTC_999 SEC7.066 22.7 µM -0.642631074064424 0.260880978379874 no 2514 0.260231757465222 3586 740511 YDR170C SEC7 SGTC_459 nigericin 15.3 µM -0.644058294781442 0.260409882291292 no 2515 0.259768816517548 3646 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2272 7805186 180 µM -0.645601610023162 0.259900959324645 no 2516 0.259268697197036 3579 2956062 YPR165W RHO1 SGTC_2505 galangin 7.89 µM -0.647852583146113 0.259159600323535 no 2517 0.258540150826244 3517 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3174 9107204 49.47 µM -0.647930439416056 0.259133977899927 no 2518 0.258514970973127 3627 3938802 SGTC_1519 esterone 74 µM -0.65079187397001 0.258193191936659 no 2519 0.257590423237089 3556 698 A steroid. SGTC_252 miconazole 1.30953 nM -0.651734973255277 0.25788350701389 no 2520 0.257286078523377 3545 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_838 0109-0203 71.4 µM -0.652094558936575 0.257765480860965 no 2521 0.257170086953388 3608 759422 SGTC_20 0481-0013 4.944 µM -0.652811821303685 0.257530138910154 no 2522 0.256938800831038 3587 182045 SGTC_2398 5228213 48.84 µM -0.654646326643927 0.25692872496422 no 2523 0.25634774487676 3630 80771 YMR134W ERG29 SGTC_3342 9147791 14.508 µM -0.654820783215276 0.256871570175168 no 2524 0.25629157395099 3585 1838168 SGTC_1283 0922-0125 16.4 µM -0.654998510378393 0.256813350691856 no 2525 0.256234356569399 3592 3360884 SGTC_2072 5231554 129 µM -0.656752084710259 0.256239286963318 no 2526 0.255670169065441 3674 789545 SGTC_3245 9134821 49.47 µM -0.656855966329446 0.256205300470559 no 2527 0.255636767002047 3547 17014901 SGTC_2186 6124449 200 µM -0.65709760794689 0.256126252737908 no 2528 0.255559078448941 3572 3834182 YLR033W RSC58 SGTC_1420 4'-methoxyflavone 42 µM -0.657480297861065 0.256001090188848 no 2529 0.25543606765376 3607 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1049 3226-0134 66 µM -0.658232313471348 0.255755228984174 no 2530 0.25519443198855 3636 5702385 SGTC_785 1270-0111 65.3 µM -0.660252801057519 0.255095269279404 no 2531 0.254545806729852 3609 6741994 SGTC_1042 0350-0096 82 µM -0.660656943028974 0.25496336980361 no 2532 0.254416171138004 3614 3122515 SGTC_3310 9130229 44.1445 µM -0.661042920620396 0.254837431945185 no 2533 0.254292394397675 3609 7761258 SGTC_2019 4016004 108 µM -0.661193265786023 0.254788385713249 no 2534 0.254244189691514 3583 45595336 SGTC_3304 9125678 46.087 µM -0.662361610886117 0.254407411743409 no 2535 0.253869750158989 3609 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2570 licareol 100 µM -0.662512648064988 0.254358183341053 no 2536 0.2538213658283 3561 443158 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.665833332126832 0.253277116905848 no 2537 0.252758818532989 3634 5106787 A p450 inhibitor. SGTC_1850 st056238 17 µM -0.665905519195405 0.253253642877753 no 2538 0.252735746265727 3628 5393177 SGTC_1947 st076332 61.6 µM -0.665939293644795 0.25324266038418 no 2539 0.252724951733588 3590 24208416 SGTC_3009 9080819 71.4286 µM -0.666499548740529 0.253060517845905 no 2540 0.252545926008867 3625 17027216 SGTC_2397 5161689 200 µM -0.667481886295103 0.252741320022616 no 2541 0.252232188045147 3674 2259942 SGTC_1071 trifluoperazine 6.31 µM -0.668014874157934 0.252568221303798 no 2542 0.252062048974871 3675 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_375 3970-0961 9.27 µM -0.668254387606815 0.252490454752796 no 2543 0.251985611805172 3582 2898222 SGTC_2826 7992541 19.48 µM -0.668673437542949 0.252354425657008 no 2544 0.251851907651106 3683 2985066 SGTC_1151 3909-8316 15.3 µM -0.66873394756617 0.252334786503651 no 2545 0.251832604117319 3645 800431 SGTC_1498 4478-3555 97.6 µM -0.669518240787862 0.252080308952217 no 2546 0.251582474426814 3607 3437919 SGTC_2802 7925815 54.55 µM -0.670061989330928 0.251903959800851 no 2547 0.25140913720367 3629 1262923 SGTC_3212 9128307 49.47 µM -0.670332484287769 0.251816256825642 no 2548 0.251322931809657 3566 27243542 SGTC_570 0987-0065 62.6 µM -0.670536804166985 0.251750020581353 no 2549 0.251257826444437 3520 3104428 SGTC_1156 4092-0367 4.88 µM -0.67137342123479 0.251478902758487 no 2550 0.250991336228613 3626 1357585 SGTC_2147 5545932 89.7195 µM -0.671399122415407 0.251470576363803 no 2551 0.250983151920853 3629 797404 SGTC_772 k072-0172 35.3 µM -0.671504062411711 0.251436580533688 no 2552 0.250949736196804 3564 5861980 SGTC_898 1000-0849 28.3 µM -0.673184098841214 0.250892655313423 no 2553 0.250415088041256 3607 6751807 SGTC_14 0354-0009 295 µM -0.673475473737302 0.250798383778106 no 2554 0.250322423517016 3666 1713507 SGTC_812 4251-0442 148 µM -0.675268638998086 0.250218635561635 no 2555 0.249752552415316 3633 5723007 SGTC_2212 7123476 200 µM -0.675691985911254 0.25008186705521 no 2556 0.249618112603231 3590 1085715 SGTC_2531 methyl deoxycholate 70.07 µM -0.675712136897203 0.250075357968937 no 2557 0.249611714330638 3613 16667744 Haematoxylin. SGTC_2121 5257820 149.641 µM -0.677319013108307 0.249556601083219 no 2558 0.249101785035788 3671 791256 SGTC_1409 3909-8004 61.9 µM -0.677396269334517 0.249531674433784 no 2559 0.249077282360909 3650 2119279 SGTC_3284 9108171 64.8615 µM -0.677476055828029 0.2495059327846 no 2560 0.249051978529449 3594 8687505 SGTC_936 3005-4620 401 µM -0.678322283465708 0.249232999822708 no 2561 0.248783686457646 3656 777207 SGTC_1782 st039423 80.636 µM -0.679577357072589 0.248828494708591 no 2562 0.248386055432439 3630 2068169 SGTC_2438 5259590 200 µM -0.679581505293618 0.248827158333576 no 2563 0.248384741759559 3649 1201127 SGTC_1723 st034307 2.5525 µM -0.680983547650125 0.248375700701163 no 2564 0.247940950398924 3672 867466 SGTC_1946 st076057 65.1 µM -0.681850109316882 0.248096886322814 no 2565 0.247666867591605 3540 953009 SGTC_163 TUB2.036 7.546 µM -0.682166867983558 0.2479950115781 no 2566 0.247566721117501 3677 15992207 YJR013W GPI14 SGTC_1230 0170-0365 3.77 µM -0.686670902128062 0.246548859222333 no 2567 0.246145068679045 3741 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2111 5486399 200 µM -0.68761867036891 0.246245126786947 no 2568 0.245846473879421 3661 689674 SGTC_3113 9123498 49.47 µM -0.688660406489927 0.245911511933858 no 2569 0.245518498881945 3688 8897275 SGTC_834 0312-0008 75.7 µM -0.688720981180477 0.245892120420494 no 2570 0.245499435083085 3665 6385573 YIL048W NEO1 SGTC_1450 4112-4260 37.6 µM -0.690680109648777 0.245265395830113 no 2571 0.244883295855947 3647 1633175 SGTC_2782 7736369 71.43 µM -0.691441078800638 0.245022193797333 no 2572 0.24464419824024 3720 2950836 YOL077C BRX1 SGTC_2962 9082311 13.18 µM -0.691496960015758 0.245004339547894 no 2573 0.244626645237288 3652 16459453 SGTC_938 3126-1755 342 µM -0.691806830678806 0.244905347458036 no 2574 0.244529323216022 3668 1777771 SGTC_1681 tripelennamine 100 µM -0.692390363019191 0.244718989140358 no 2575 0.244346108074228 3659 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_143 4032-1194 15.74 µM -0.692391074489908 0.244718761969938 no 2576 0.244345884734674 3673 1806963 SGTC_1372 2752-0194 270 µM -0.694566251215484 0.244024765800627 no 2577 0.243663584198329 3642 823334 SGTC_609 0986-0026 86.3 µM -0.696460194777878 0.243421363534367 no 2578 0.243070338559983 3651 2848610 SGTC_615 k087-0205 167 µM -0.698001385214753 0.24293094242976 no 2579 0.242588163888957 3664 9642773 SGTC_1534 6-azauridine 81.6 µM -0.69826663703662 0.24284659078778 no 2580 0.242505229851491 3710 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2421 5690543 90.72 µM -0.699662702841533 0.242402894983962 no 2581 0.242068987020226 3682 3397993 SGTC_574 1315-0397 40 µM -0.700039947087487 0.242283075132183 no 2582 0.24195117876228 3704 6794277 SGTC_3332 9141069 11.198 µM -0.700703113692487 0.242072518807527 no 2583 0.241744156245228 3639 17332883 SGTC_2319 6033012 152.6 µM -0.701035061598283 0.241967162159356 no 2584 0.241640567284051 3650 847246 SGTC_554 4483-2211 187 µM -0.702839658163197 0.241394838266168 no 2585 0.241077839666639 3690 747107 SGTC_886 0866-0150 153 µM -0.703430371663788 0.24120765464749 no 2586 0.240893792297741 3700 271463 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.70386844526853 0.241068890088973 no 2587 0.240757351997054 3720 368090 SGTC_153 4077-0274 519.67 µM -0.7045912575379 0.240840026400124 no 2588 0.240532320327163 3755 3121976 SGTC_882 0843-0131 351 µM -0.705013892838554 0.24070626238212 no 2589 0.240400795220074 3697 5425421 SGTC_2851 9015922 71.43 µM -0.705820361779045 0.240451127298763 no 2590 0.240149928907811 3681 2996893 SGTC_991 3996-0057 64.7 µM -0.706128453295718 0.240353698143308 no 2591 0.240054129317961 3681 715343 SGTC_1128 3448-9350 235 µM -0.706227600993991 0.240322348798839 no 2592 0.240023304245379 3720 619386 SGTC_559 1550-0661 158 µM -0.70663031540529 0.240195038107588 no 2593 0.239898122307662 3717 5830875 SGTC_58 0957-0393 9 µM -0.70698134185559 0.240084097595721 no 2594 0.239789036390548 3632 6997992 SGTC_2993 9054257 71.4286 µM -0.707371981845563 0.239960670230376 no 2595 0.239667671887144 3690 6470217 YGL055W OLE1 SGTC_2517 totarol 10 µM -0.709657730049827 0.239239154906521 no 2596 0.238958205301923 3660 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1726 st035556 14.5795 µM -0.710641422176415 0.23892900956903 no 2597 0.238653233839869 3786 5919439 SGTC_1246 0422-0085 105 µM -0.711909627526318 0.238529485568908 no 2598 0.238260370008282 3679 264295 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.712252420518621 0.238421557967087 no 2599 0.238154240670721 3826 16725076 SGTC_3018 9082602 49.47 µM -0.712679789613625 0.238287039227991 no 2600 0.238021962703788 3688 17332089 SGTC_69 0096-0274 206.684 µM -0.713028578492421 0.238177285222513 no 2601 0.237914036496495 3805 6741392 SGTC_2780 5215298 71.43 µM -0.713930951853179 0.237893462393737 no 2602 0.237634938455264 3690 2834131 SGTC_2281 7943571 200 µM -0.714324031982307 0.237769885202042 no 2603 0.237513417598546 3778 1244024 SGTC_2114 5491910 81.25 µM -0.714950996717656 0.237572851865313 no 2604 0.237319661844535 3753 2849228 SGTC_2090 5301565 104.445 µM -0.715253648968424 0.237477770804982 no 2605 0.237226161954702 3723 2056344 SGTC_200 k038-0079 37.545 µM -0.715718697991711 0.237331711983111 no 2606 0.23708253145082 3660 3436683 SGTC_1211 1056-0033 32.3 µM -0.716465868286555 0.237097150135063 no 2607 0.236851867819624 3707 6741922 SGTC_1155 4088-0394 48.2 µM -0.717110719122081 0.236894812255225 no 2608 0.236652891114803 3676 2326248 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.717549541852775 0.236757175082146 no 2609 0.23651753952879 3759 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.71778597370229 0.236683036239554 no 2610 0.236444631558558 3697 551469 SGTC_3152 9099253 49.47 µM -0.718601190287478 0.236427503601527 no 2611 0.236193339895332 3688 25236131 SGTC_2675 theaflavin digallate 100 µM -0.719345353659555 0.236194375497891 no 2612 0.23596407896937 3684 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_685 1278-0033 54.9 µM -0.722357643341661 0.235251993908012 no 2613 0.235037310654762 3748 3590572 SGTC_3036 9090181 49.47 µM -0.722442376802789 0.235225515470545 no 2614 0.235011270463619 3725 25236586 SGTC_2913 7966556 36.57 µM -0.722456846257659 0.235220994061743 no 2615 0.235006823886502 3631 2976516 SGTC_2098 5376439 882.5 nM -0.722896620376852 0.235083596537824 no 2616 0.234871700023416 3751 2844116 SGTC_1393 3470-5649 58.2 µM -0.72306625398537 0.235030610185835 no 2617 0.234819590316002 3670 4108395 SGTC_285 1486-1325 46 µM -0.723186397566542 0.234993086413141 no 2618 0.234782687304424 3704 22310230 SGTC_1275 0867-0008 21.1 µM -0.723219305382807 0.234982809076455 no 2619 0.234772579978594 3700 3422836 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.723700550064215 0.234832541437317 no 2620 0.234624797690758 3706 75037 A free radical scavenger. SGTC_3151 9099821 49.47 µM -0.723724866318062 0.23482495014816 no 2621 0.234617331936732 3667 17174189 SGTC_3145 9085516 49.47 µM -0.728053452722882 0.233475772469334 no 2622 0.233290433011176 3751 25236195 SGTC_857 0438-0306 1.35 µM -0.728150186082537 0.233445670833378 no 2623 0.233260827703437 3761 4686136 SGTC_1077 5-fluorocytosine 377 nM -0.730093295375867 0.232841467259451 no 2624 0.232666579647792 3748 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1888 azatryptophan 97.5 µM -0.731331699613714 0.232456843226549 no 2625 0.232288286285673 3723 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1859 st055998 20 µM -0.732962050020453 0.231951027638246 no 2626 0.231790787987211 3712 676301 SGTC_833 3852-0053 558 µM -0.73311832474023 0.231902575677223 no 2627 0.231743132251677 3765 3123681 SGTC_2920 7982904 15.77 µM -0.733243596951236 0.231863739913165 no 2628 0.231704934625815 3723 6456808 SGTC_416 estradiol valerate 100 µM -0.734258437689999 0.231549261690387 no 2629 0.231395621801623 3753 13791 A steroid. SGTC_3 0833-0587 95.581 µM -0.734316993688332 0.231531123651782 no 2630 0.231377781575986 3675 5382644 SGTC_2240 6690706 185.951 µM -0.734933585592369 0.231340179048406 no 2631 0.231189971411976 3660 805876 SGTC_300 r073-0011 5.04 µM -0.735027943694957 0.231310966223205 no 2632 0.231161238010787 3750 2735780 SGTC_311 1315-0136 58 µM -0.735288814495344 0.23123021255796 no 2633 0.231081809465871 3757 6759207 SGTC_3312 9133330 71.43 µM -0.73682188748621 0.230755961241805 no 2634 0.230615335517956 3780 17617324 SGTC_1591 genipin 88.4 µM -0.736868985958965 0.23074140008432 no 2635 0.23060101302203 3741 442424 A DNA cross-linking agent. SGTC_1945 st075991 56.6 µM -0.737908090040155 0.230420276999141 no 2636 0.230285151252794 3685 1084980 SGTC_868 0527-0199 213 µM -0.738268079297059 0.230309084785919 no 2637 0.230175779938848 3696 2849450 SGTC_151 3013-0144 2.285 µM -0.738520903423733 0.230231011300358 no 2638 0.230098984722686 3716 906558 YHR107C CDC12 SGTC_550 4123-0385 25.7 µM -0.73895533614613 0.230096890656891 no 2639 0.229967059462437 3763 5731123 SGTC_942 3253-1115 227 µM -0.739654691560456 0.229881073369813 no 2640 0.229754773428934 3773 46497897 SGTC_1826 st055655 41.6 µM -0.740648713908976 0.229574518555214 no 2641 0.22945323156266 3778 676168 SGTC_1005 4092-0690 4.4 µM -0.740685370343893 0.229563218152958 no 2642 0.229442115883778 3760 1529343 SGTC_2514 salinomycin 42.74 µM -0.741876308255506 0.2291962468106 no 2643 0.229081140691866 3831 23682228 A polyether potassium ionophore. SGTC_2423 st077119 87.2 µM -0.74225110670155 0.229080825852529 no 2644 0.228967604620543 3686 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_586 0957-0265 8.15 µM -0.742841687052509 0.228899020017997 no 2645 0.228788766760837 3621 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2734 clemastine 41.6 µM -0.743115764844985 0.228814674694683 no 2646 0.228705797951004 3734 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1442 4112-3290 3 µM -0.743566688827566 0.228675944293016 no 2647 0.228569331044026 3746 704353 SGTC_235 0330-0087 5 mM -0.746000530259375 0.227927969330257 no 2648 0.227833547359504 3782 46494818 YHR062C RPP1 SGTC_1562 morin hydrate 59.1 µM -0.747024777973128 0.22761360662804 no 2649 0.227524302137658 3790 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2860 9025725 38.96 µM -0.74786557111273 0.227355732459787 no 2650 0.227270623066315 3752 40546248 SGTC_2528 xanthyletin 44.79 µM -0.748581345580009 0.227136331720795 no 2651 0.227054789536964 3809 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2557 derrustone 83.84 µM -0.748589020495871 0.227133979835886 no 2652 0.227052475881075 3725 629853 An antioxidant. SGTC_180 1486-1293 102.781 µM -0.7486388839315 0.227118700124944 no 2653 0.227037444531027 3731 4140536 SGTC_3064 1327-0027 10 µM -0.749434258562055 0.226875050898917 no 2654 0.226797754440425 3639 16000455 YPR107C YTH1 SGTC_2964 9083345 53.42 µM -0.751380364328458 0.226279517295531 no 2655 0.226211888236093 3745 17741579 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.75182637424284 0.226143156970522 no 2656 0.22607773954334 3788 4174840 SGTC_2371 9071574 200 µM -0.752215460809878 0.22602423797413 no 2657 0.225960748709312 3730 45596039 SGTC_2467 5474540 200 µM -0.752781920904011 0.225851170392696 no 2658 0.225790486278693 3735 5413519 SGTC_1780 st038448 24.544 µM -0.753971837503843 0.225487865584627 no 2659 0.225433066271963 3833 728868 YDL195W SEC31 SGTC_3162 9099653 49.47 µM -0.754771264036033 0.225243970922977 no 2660 0.225193119318212 3714 25237511 SGTC_325 2810-4341 181 µM -0.754847691126019 0.225220661837089 no 2661 0.225170187394066 3747 774970 SGTC_168 3970-0862 530.542 µM -0.755823954436243 0.224923036774764 no 2662 0.22487737629669 3768 3135186 SGTC_160 3453-0671 289.699 µM -0.756537630828551 0.224705605475896 no 2663 0.224663459660273 3792 5322268 SGTC_560 2332-1943 155 µM -0.756741374693627 0.224643553994359 no 2664 0.224602410866699 3741 21177716 SGTC_862 0452-0056 10.2 µM -0.75858494477351 0.224082525137874 no 2665 0.224050440751212 3712 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1361 1608-0041 5.61 µM -0.758796450454522 0.224018211392254 no 2666 0.223987164660914 3728 X1361 SGTC_280 3448-3607 3.04 µM -0.759566375312593 0.223784184510457 no 2667 0.223756912244306 3744 626179 SGTC_2411 st077133 39.94 µM -0.759933176343158 0.223672740314438 no 2668 0.223647264691819 3887 1403142 YNL221C POP1 SGTC_2226 7298446 200 µM -0.761776805009565 0.223113073595322 no 2669 0.223096613116957 3754 3283010 SGTC_445 e6 berbamine 66 µM -0.764020875708032 0.222432922661364 no 2670 0.222427401164022 3862 6610268 A calcium/calmodulin antagonist. SGTC_1573 oleylamine 1.06 µM -0.764281012531885 0.222354154866959 no 2671 0.222349898999049 3797 5356789 An amine of the fatty acid oleic acid. SGTC_1501 4491-0275 38.4 µM -0.765691281783369 0.221927411259342 no 2672 0.221930007873247 3741 5104718 SGTC_1891 st059073 26.2 µM -0.767730893342151 0.22131105850202 no 2673 0.221323539181533 3789 688754 SGTC_940 3232-1287 54.8 µM -0.768164333839462 0.221180202820551 no 2674 0.221194779952258 3723 1585493 YIL048W NEO1 SGTC_3257 9139206 32.98 µM -0.769723269420336 0.220709926250782 no 2675 0.220732031925268 3791 4910041 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.769942347814026 0.220643883856378 no 2676 0.220667046058158 3773 2333 A French combination drug. SGTC_987 1497-1013 404 µM -0.770752220745165 0.220399841476684 no 2677 0.220426906235836 3776 1676435 SGTC_25 0118-0223 35.662 µM -0.77090117074452 0.220354974603852 no 2678 0.22038275657505 3797 5333628 SGTC_3223 9129970 49.47 µM -0.772580371637373 0.219849526337388 no 2679 0.219885382300324 3840 17248386 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.772939675017189 0.219741460628507 no 2680 0.21977904144636 3788 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3290 9121031 71.43 µM -0.773698389481247 0.219513366452761 no 2681 0.219554586320866 3783 17014854 SGTC_117 lucigenin 22.078 µM -0.777376577399242 0.218409513573152 no 2682 0.218468313653045 3814 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1056 3448-1962 115 µM -0.777541601425503 0.21836006362864 no 2683 0.218419650057515 3810 715507 SGTC_3235 9132602 49.47 µM -0.778184017562586 0.21816762313718 no 2684 0.218230268752955 3794 4912240 SGTC_1529 apigenin 74 µM -0.778340441294094 0.21812078005601 no 2685 0.218184170088909 3825 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2897 9048598 12.99 µM -0.779157738125057 0.21787612438809 no 2686 0.217943400905216 3793 6467404 SGTC_3032 9089427 49.47 µM -0.779192670723286 0.217865670934112 no 2687 0.217933113453144 3779 17173707 SGTC_840 0245-0196 390 µM -0.781539001377372 0.217164202415592 no 2688 0.217242773666278 3905 3827528 SGTC_1368 1852-0141 284 µM -0.784468058971552 0.216290353228646 no 2689 0.216382758456899 3792 2838987 SGTC_1621 st003705 32.4 µM -0.785635910811737 0.215942507063096 no 2690 0.216040409882401 3841 24207032 SGTC_1180 1193-0155 285 µM -0.786722301390897 0.21561921543286 no 2691 0.215722223048026 3835 2921347 SGTC_783 0848-0141 92.7 µM -0.787199375708836 0.215477334839841 no 2692 0.215582581319021 3791 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.787667797084446 0.215338080310749 no 2693 0.215445523358906 3835 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1277 0873-0036 22 µM -0.789883683548473 0.21468003924167 no 2694 0.21479785056759 3866 5965735 SGTC_962 1254-0300 21.5 µM -0.789935454996754 0.21466467890909 no 2695 0.214782732029049 3775 7340576 SGTC_216 k038-0035 28.382 µM -0.790736955862239 0.21442695906768 no 2696 0.214548752916252 3733 4444231 YPR107C YTH1 SGTC_2182 6325192 200 µM -0.790986332732251 0.214353026777581 no 2697 0.214475983505711 3734 736248 SGTC_2409 alverine citrate 63.97 µM -0.791362607790666 0.214241501287056 no 2698 0.2143662117395 4006 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2850 9015429 58.44 µM -0.791657659091065 0.214154073610123 no 2699 0.214280158466269 3878 6457570 SGTC_2336 9001819 198.65 µM -0.795799679838564 0.212928930081389 no 2700 0.213074238933151 3842 2989602 SGTC_1745 st081495 74 µM -0.796094269991537 0.212841951097479 no 2701 0.212988622199516 3748 13842402 YBL026W LSM2 SGTC_3132 9126706 49.47 µM -0.796412182523512 0.212748109353135 no 2702 0.212896249806848 3873 850858 SGTC_3207 9114163 49.47 µM -0.796523100370977 0.212715374195048 no 2703 0.212864027114713 3819 849233 SGTC_444 curcumin 90.4 µM -0.798195203368916 0.212222243279442 no 2704 0.212378610263312 3779 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_781 4335-2806 94.4 µM -0.798968368223312 0.21199445025949 no 2705 0.212154376898884 3949 845254 SGTC_626 0214-0009 33 µM -0.800359369049189 0.211584988118916 no 2706 0.211751307371344 3888 3437874 SGTC_2773 thioridazine 9.09 µM -0.800558645710441 0.211526365957515 no 2707 0.211693599806482 3842 5452 An antipsychotic. SGTC_2561 acetosyringone 100 µM -0.801569189118135 0.211229236027815 no 2708 0.211401103147528 3847 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1296 1068-0102 11.9 µM -0.802371509723832 0.210993504068603 no 2709 0.211169044177097 3854 767053 SGTC_333 3486-0131 40.1 µM -0.806973592492101 0.209644336338426 no 2710 0.209840848781852 3900 6744690 SGTC_2628 lathosterol 100 µM -0.807563853193795 0.209471660648169 no 2711 0.209670851172743 3905 6710616 SGTC_355 1311-2252 105 µM -0.80758613481064 0.209465143992222 no 2712 0.209664435558381 3849 5338538 SGTC_266 formosanin C 406 nM -0.807628142406925 0.209452858446447 no 2713 0.209652340496172 3778 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1417 3966-0327 90.4 µM -0.808680804262278 0.209145135301102 no 2714 0.209349386198934 3913 651118 SGTC_2107 5363541 170.161 µM -0.809060613854892 0.209034171483119 no 2715 0.209240140921291 3814 244052 SGTC_1713 st033146 12.748 µM -0.80963581722837 0.208866188146099 no 2716 0.209074758108151 3813 674619 SGTC_1224 0823-0416 294 µM -0.810494847437152 0.208615463692269 no 2717 0.208827912610914 3928 3598164 SGTC_1025 k007-0731 70 µM -0.810596052087439 0.208585936859881 no 2718 0.208798842392997 3819 6256118 SGTC_958 1222-0007 33 µM -0.811226337235886 0.208402104287908 no 2719 0.208617851753963 3921 7312461 SGTC_2558 carylophyllene oxide 100 µM -0.811421776318503 0.208345120821979 no 2720 0.208561748891434 3941 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1572 epiandrosterone 68.9 µM -0.81142878378292 0.208343077851634 no 2721 0.208559737489617 3765 441302 A steroid. SGTC_1898 st060199 18.6 µM -0.812237633132495 0.20810734368851 no 2722 0.208327644627352 3842 688866 SGTC_1617 st002906 78 µM -0.813661913053423 0.207692628942945 no 2723 0.207919329430405 3858 5150859 SGTC_1907 st060210 83.7 µM -0.813778123724464 0.20765881285462 no 2724 0.207886034804289 3889 688793 SGTC_2910 7948405 25.97 µM -0.814282457172741 0.207512094798838 no 2725 0.207741578588117 3737 2971328 SGTC_197 4544-0043 41.561 µM -0.814573909525316 0.207427334940953 no 2726 0.207658124939686 3845 896523 SGTC_36 0335-0881 14.2 µM -0.815222596752701 0.20723875790491 no 2727 0.207472452777459 3776 23828853 SGTC_3043 9092303 49.47 µM -0.8164644211753 0.20687803549883 no 2728 0.207117282256251 3864 25236084 SGTC_1262 0737-0114 49.6 µM -0.816483169029523 0.206872592512845 no 2729 0.20711192299552 3892 765919 SGTC_2487 5918373 44.05 µM -0.817284695873965 0.206639967867907 no 2730 0.206882875303817 3862 2876279 SGTC_2572 astragaloside iv 100 µM -0.817499197458594 0.206577740025328 no 2731 0.206821603865912 3920 45006101 An anti-inflammatory agent. SGTC_95 0471-0001 561.058 µM -0.819263628109183 0.206066292311836 no 2732 0.206318009711088 3826 4015405 SGTC_2646 retinol 96.75 µM -0.820164739093347 0.205805381175988 no 2733 0.206061100126207 3841 445354 A vitamin A analog and teratogen. SGTC_541 4513-1321 94 µM -0.821008403024626 0.205561281239716 no 2734 0.205820740912916 3865 747515 SGTC_3148 9097893 49.47 µM -0.822227356475068 0.205208901347268 no 2735 0.20547375595898 3875 17174100 SGTC_1527 coumarin 137 µM -0.823398042497538 0.204870812902152 no 2736 0.205140837937116 3985 323 A hepatotoxic, DNA x-linker. SGTC_2372 9071633 200 µM -0.825030371500744 0.204399957485318 no 2737 0.204677174002023 3928 21321366 SGTC_3154 9100113 49.47 µM -0.826899546158253 0.203861574395546 no 2738 0.204147000340182 3898 25237525 SGTC_463 ikarugamyin 104 µM -0.827167091662886 0.203784581794102 no 2739 0.204071180570438 3906 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_651 3253-0966 34.4 µM -0.828012816851948 0.203541318217485 no 2740 0.203831620700992 3896 781462 SGTC_1235 benzylparaben 21.5 µM -0.830139601113139 0.202930337968822 no 2741 0.203229929650088 3881 7180 SGTC_178 4092-0806 87.505 µM -0.832801794233443 0.202167091767458 no 2742 0.202478261333338 3820 2169044 SGTC_752 1896-0090 130 µM -0.832903182687425 0.202138057863426 no 2743 0.202449667271978 3852 772567 SGTC_3234 9132280 49.47 µM -0.833997370222732 0.201824881792715 no 2744 0.202141232877856 3927 17612295 SGTC_2123 5259487 200 µM -0.834341603552696 0.201726416157523 no 2745 0.202044257044084 3882 2173474 SGTC_1998 st075797 76.8 µM -0.835643616012246 0.201354244517534 no 2746 0.20167771196652 3826 24208315 SGTC_1987 st072290 61.9 µM -0.835719249227868 0.20133263791951 no 2747 0.201656431804353 3907 54697379 SGTC_1575 cyproterone acetate 48 µM -0.836855184557499 0.201008295620352 no 2748 0.201336986852091 3908 9880 An androgen receptor antagonist and liver toxin. SGTC_1488 4013-0813 75.9 µM -0.838165855249213 0.20063445106492 no 2749 0.200968780406791 3842 2910057 SGTC_2649 anisomycin 9.56 µM -0.839205453998802 0.200338221841508 no 2750 0.200677013639839 3876 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_194 1486-1323 56.904 µM -0.840266376017347 0.200036187708657 no 2751 0.200379524747583 3924 5178754 SGTC_779 1360-0071 233 µM -0.843261354396498 0.199185025068057 no 2752 0.199541145595427 3956 7566 SGTC_1912 st060209 90.8 µM -0.843871603092279 0.199011862385884 no 2753 0.199370578996096 3938 688787 SGTC_53 0973-0023 39.979 µM -0.843907458149017 0.199001691064637 no 2754 0.199360560116159 3801 674768 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.844838612542788 0.198737651973977 no 2755 0.199100476379033 3905 6708760 SGTC_2970 9090938 41.86 µM -0.846121069552743 0.198374343154036 no 2756 0.198742604006182 3953 17217104 SGTC_1023 4482-3888 16 µM -0.846832518920936 0.198172968740769 no 2757 0.198544239905931 3900 3303168 SGTC_1013 4112-3890 241 µM -0.848706127413128 0.197643238122597 no 2758 0.198022417903413 3851 705171 SGTC_2636 apigenin dimethyl ether 100 µM -0.849178201661273 0.197509902348794 no 2759 0.197891070421721 3915 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3022 9087993 49.47 µM -0.84921798701586 0.197498667595453 no 2760 0.197880003156916 3945 17173644 SGTC_37 0566-0070 1.56 µM -0.849407948201628 0.197445030895301 no 2761 0.197827165984092 3905 1626686 SGTC_682 0kpi-0099 17 µM -0.849938466992171 0.197295282334171 no 2762 0.197679648816192 3948 1714895 YML126C ERG13 SGTC_1626 st003712 1.76 µM -0.851083651933789 0.196972267383562 no 2763 0.197361443015783 3899 24207035 SGTC_295 k015-0027 31 µM -0.851970948746475 0.19672221352142 no 2764 0.197115108203073 3920 3887424 SGTC_2771 fluoxetine 41.05 µM -0.853828072851379 0.196199470142976 no 2765 0.196600128736136 3871 3386 A selective serotonin reuptake inhibitor. SGTC_1685 st024049 53.0905 µM -0.854111590721043 0.196119739694378 no 2766 0.196521581169742 3935 1941139 SGTC_2133 5320837 200 µM -0.854623391488481 0.195975861650544 no 2767 0.196379836834027 3925 2841355 SGTC_571 k831-0106 44.2 µM -0.855406773753043 0.195755760350829 no 2768 0.196162997464664 3815 4783639 SGTC_475 α-linolenic acid 10 µM -0.855974635082344 0.195596306263035 no 2769 0.196005904867437 3934 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2301 7769476 200 µM -0.85717312192911 0.195260033016956 no 2770 0.195674607247504 3954 977820 SGTC_3271 9137798 49.47 µM -0.858737736537982 0.194821560121802 no 2771 0.195242612902912 3831 6498326 SGTC_2470 5664817 21.68 µM -0.859991760156932 0.194470561011338 no 2772 0.194896792310958 3932 2859561 SGTC_3298 9116858 71.43 µM -0.860482768807975 0.194333233441302 no 2773 0.1947614889825 3975 2506942 SGTC_2731 amoxapine 43.43 µM -0.861068265008534 0.194169556361474 no 2774 0.194600223186328 3996 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_981 1488-1094 54.9 µM -0.863005606465146 0.193628566076427 no 2775 0.194067192222285 3892 3449522 SGTC_1339 1486-1321 22.7 µM -0.864340383803472 0.193256373345002 no 2776 0.193700465958017 3938 3469382 SGTC_3189 9110682 49.47 µM -0.865096389474992 0.193045760612511 no 2777 0.193492943120309 4020 17122418 SGTC_1387 3342-1166 1.8 µM -0.865934426293315 0.192812458992473 no 2778 0.193263061373069 3919 3418228 SGTC_1385 3091-4834 14.1 µM -0.867351078714771 0.192418468096157 no 2779 0.192874838910093 3914 4072814 SGTC_1305 1181-0477 144 µM -0.867659209808558 0.192332837743211 no 2780 0.192790461121405 3981 6252086 SGTC_1446 4239-0190 62 µM -0.869837711650407 0.191728092042766 no 2781 0.192194549621882 3940 1340085 SGTC_3155 9099265 49.47 µM -0.871770239108023 0.191192603887015 no 2782 0.191666866668583 3963 25236499 SGTC_2158 5657123 3.6195 µM -0.872801239615741 0.190907297205851 no 2783 0.191385711919248 3864 2858827 SGTC_225 nsc-122657 1.016 µM -0.873544512585966 0.190701774889199 no 2784 0.191183177591472 3934 275685 SGTC_78 0336-0123 156.75 µM -0.874018828472833 0.190570692867047 no 2785 0.191054000044859 3770 6765896 SGTC_1472 k841-0093 193 µM -0.874635851952844 0.190400254953573 no 2786 0.190886036931419 4040 X1472 SGTC_224 benfluorex 43.875 µM -0.875080897519831 0.19027737993821 no 2787 0.190764945056832 3930 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2873 9040596 71.43 µM -0.876032577961391 0.190014788890829 no 2788 0.190506161774081 3929 6463863 SGTC_502 l-744,832 89.3 µM -0.87619099545534 0.189971099408125 no 2789 0.19046310543583 3939 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1244 0416-0015 52.5 µM -0.876956680247037 0.189760020572143 no 2790 0.190255083985599 3919 96201 SGTC_3046 9092212 49.47 µM -0.878108839186567 0.189442673077088 no 2791 0.189942328283294 3981 25236637 SGTC_3198 9112019 49.47 µM -0.878188779493643 0.189420666661891 no 2792 0.18992064006894 3993 45595555 SGTC_755 1995-0008 37.3 µM -0.879972943892236 0.188929921382145 no 2793 0.189436983388766 3909 689533 SGTC_2036 5160441 105 µM -0.88230748092005 0.188288977021929 no 2794 0.188805276025265 3928 134534 YIL048W NEO1 SGTC_3274 9138298 49.47 µM -0.884080758104889 0.187803023498484 no 2795 0.188326309772177 3905 17015756 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.88449964694424 0.187688343302009 no 2796 0.188213276471799 3980 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1333 1482-0047 286 µM -0.884558852672029 0.187672137898718 no 2797 0.188197303727949 3934 3811116 SGTC_2768 sulfasalazine 50.2 µM -0.884583021786125 0.187665522735872 no 2798 0.188190783533908 3906 5384001 An antioxidant and salicylic acid derivative. SGTC_1266 0828-0227 32.9 µM -0.885266297732449 0.187478567556588 no 2799 0.188006511256049 3979 3913820 SGTC_1206 3978-0017 132 µM -0.88665106626318 0.187100026021428 no 2800 0.187633395639582 4061 3873677 SGTC_1840 st055363 71 µM -0.886762122896268 0.18706968797442 no 2801 0.187603492082076 3997 676033 SGTC_1799 st045822 46.1415 µM -0.888379378957334 0.186628236714378 no 2802 0.187168356908185 3889 3674992 SGTC_2214 7179297 48.276 µM -0.889954253417885 0.186198974495645 no 2803 0.186745225210705 3967 769744 SGTC_65 0798-0905 34.986 µM -0.890595615308566 0.186024334494369 no 2804 0.186573076172378 4030 3602145 SGTC_2858 9025781 8.96 µM -0.891782744038773 0.185701352640922 no 2805 0.18625469630655 3895 4894980 YPL153C RAD53 SGTC_2492 derrusnin 100 µM -0.893348639330707 0.185275852321684 no 2806 0.185835249087213 3858 1715307 Part of coumarin class of compounds. SGTC_1739 st037196 92.5 µM -0.895930714025304 0.184575549268653 no 2807 0.185144884506596 4030 612214 SGTC_1561 5-methoxyflavone 52.9 µM -0.896346257685964 0.184463000653292 no 2808 0.185033930355694 3890 94525 SGTC_2260 7964312 200 µM -0.896454302473171 0.184433744076996 no 2809 0.185005088127408 4036 231951 SGTC_2549 cedrol 20.94 µM -0.897053969560717 0.184271417538127 no 2810 0.184845059595979 3891 6708665 A sedative which affects the nervous system. SGTC_1833 st055984 71 µM -0.897467955799819 0.184159405660782 no 2811 0.184734632495153 4001 676288 SGTC_1416 3966-0321 25.3 µM -0.898354132045082 0.183919776258106 no 2812 0.184498390852131 3995 582530 YLR208W SEC13 SGTC_3238 9133470 49.47 µM -0.899566019062444 0.183592386470198 no 2813 0.184175623823749 3964 3534688 SGTC_29 0299-0004 12.984 µM -0.899840776550248 0.183518211606203 no 2814 0.184102495393762 3857 16871 A napthoquinone isolated from Swertia calycina. SGTC_2343 7990716 14.84 µM -0.900024839670546 0.183468531482754 no 2815 0.184053515950695 3978 6456862 SGTC_2925 9010536 32.5 µM -0.900402416029901 0.183366646812336 no 2816 0.183953067767699 3930 2994177 SGTC_2215 7188065 200 µM -0.900730616328023 0.183278114372136 no 2817 0.183865783038181 3981 940217 SGTC_298 1391-0729 10 µM -0.901405082386279 0.183096260002942 no 2818 0.183686490066409 3926 3237558 SGTC_219 mitoxanthrone 164.414 µM -0.901517571081419 0.183065940951515 no 2819 0.183656597855736 3937 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_705 1124-0212 310 µM -0.902548844246934 0.182788128142964 no 2820 0.183382693520047 3916 9554485 SGTC_1039 k821-0043 94 µM -0.904201503292553 0.182343470471437 no 2821 0.182944281608342 3989 15992768 SGTC_2346 9031566 143.75 µM -0.906799678225918 0.181645784006824 no 2822 0.18225637004705 3949 4771086 SGTC_3051 9093778 49.47 µM -0.907315085669885 0.181507580744132 no 2823 0.182120099441029 4013 17217378 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.908541780233728 0.181178915142167 no 2824 0.181796025105345 3983 77254 SGTC_2208 7283366 200 µM -0.91379383657131 0.17977596166944 no 2825 0.180412592829951 3943 898663 SGTC_1212 0520-0165 585 µM -0.914710228728428 0.179531871902616 no 2826 0.180171886543063 4126 5403258 SGTC_2491 paeonol 100 µM -0.915803483553585 0.179240945708749 no 2827 0.179884988039747 3846 11092 Increases levels of cortical cytochrome oxidase. SGTC_624 k048-0052 28 µM -0.916061737624577 0.179172264998178 no 2828 0.179817257372523 3968 6835531 SGTC_1052 3253-3998 198 µM -0.916291239573941 0.179111244589745 no 2829 0.179757080788271 3935 5450317 SGTC_2621 lithochol-11-enic acid 100 µM -0.916558539917381 0.179040190756082 no 2830 0.179687009222703 3910 6708711 SGTC_1522 st012842 45.6 µM -0.917273957521761 0.17885010556703 no 2831 0.179499550215346 3857 3491067 YOR116C RPO31 SGTC_2490 carminic acid 95.39 µM -0.919472444010362 0.178266766941328 no 2832 0.178924256217814 3937 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1008 4106-0037 6 µM -0.920505307699081 0.177993124997209 no 2833 0.1786543803248 3935 2905394 SGTC_1931 st074438 57.1 µM -0.9207133610894 0.177938036397595 no 2834 0.178600049299927 3964 2787313 SGTC_326 k292-0812 17.5 µM -0.92232676262738 0.17751120326424 no 2835 0.178179079193946 3975 3579357 SGTC_1141 3253-0389 52.6 µM -0.926233823479264 0.176480251651614 no 2836 0.177162239238811 3982 5402031 SGTC_536 3852-0578 10.6 µM -0.926405546104302 0.176435026461024 no 2837 0.177117631475133 4062 2869208 SGTC_2355 9061122 103.12 µM -0.927037066127153 0.176268771236552 no 2838 0.176953644841389 4024 5302957 SGTC_2068 5226020 147 µM -0.928298313707567 0.175937029501591 no 2839 0.176626424281252 4035 1810509 SGTC_1434 4073-0095 163 µM -0.928394918586588 0.175911636154861 no 2840 0.176601376706807 3939 24133745 SGTC_1154 4088-0362 150 µM -0.931794034558627 0.175019629894268 no 2841 0.175721489079799 4002 6618304 SGTC_189 3970-0742 2.116 µM -0.932411824762241 0.174857816245232 no 2842 0.175561868048333 3952 2891807 SGTC_2171 5739187 198.077 µM -0.932780958298004 0.174761176901246 no 2843 0.175466537346804 3944 2262761 SGTC_793 0488-0545 106 µM -0.93328589893241 0.174629038111743 no 2844 0.175336186890277 4030 292548 SGTC_3283 9109332 35.8195 µM -0.934819799856297 0.174228018123433 no 2845 0.174940586935819 3852 17027281 SGTC_1033 k072-0102 21.3 µM -0.936357652009327 0.173826553115385 no 2846 0.174544536986264 4003 5965931 SGTC_2769 toremifene 3.73 µM -0.938118629834284 0.173367563102487 no 2847 0.174091724410062 4034 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_765 1319-0117 244 µM -0.938264118451009 0.173329676762506 no 2848 0.174054347326134 3970 3487746 YGL099W LSG1 SGTC_2912 7964298 10.93 µM -0.938493005416634 0.173270083529989 no 2849 0.173995554926679 4046 2975850 SGTC_543 3844-1095 191 µM -0.938679906855049 0.173221431367291 no 2850 0.173947556385929 4027 4230703 SGTC_1895 st058434 18.3 µM -0.939287377071883 0.173063361379169 no 2851 0.173791608876397 4040 5393175 SGTC_1108 betulinic acid 729.144 nM -0.941655360976192 0.17244806519899 no 2852 0.173184558098976 4031 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2657 nystatin 74.44 µM -0.941926732374609 0.172377641360389 no 2853 0.17311507631375 4051 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1923 st058458 19.1 µM -0.942812417804296 0.172147923998106 no 2854 0.172888429459679 4066 3534982 SGTC_510 ag-490 170 µM -0.945881031920294 0.171353539430478 no 2855 0.172104634569381 4141 5328779 SGTC_1763 st044482 94.5 µM -0.948220041890471 0.170749606824134 no 2856 0.171508723101193 4029 88505 SGTC_2332 7982454 138.89 µM -0.948883391902849 0.170578578053119 no 2857 0.171339961165351 3960 2981748 SGTC_1881 5652484 16 µM -0.949355510846956 0.17045692042536 no 2858 0.171219914739092 4002 2255129 SGTC_713 1488-1073 324 µM -0.950949473923768 0.170046591817695 no 2859 0.170815012654136 3966 3312542 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.951870655448169 0.169809744030629 no 2860 0.170581291672067 4008 15053 SGTC_1778 st046819 58.9 µM -0.953865542079889 0.169297558133639 no 2861 0.170075853790279 4093 671715 SGTC_1603 st002045 67.8 µM -0.954934979653638 0.169023389449483 no 2862 0.169805289513861 4029 5887985 SGTC_1508 1080-0625 72.9 µM -0.95518189808562 0.168960128214393 no 2863 0.169742859184612 3912 767111 SGTC_590 k048-0076 22.4 µM -0.957424600850106 0.168386237663891 no 2864 0.16917649318865 4063 6832814 SGTC_2811 7967822 32.47 µM -0.957449161841089 0.168379959640922 no 2865 0.169170297347852 4101 2232244 SGTC_1774 st048371 48.465 µM -0.959965215949811 0.167737629892355 no 2866 0.168536360822375 4021 4242727 SGTC_1798 st045719 60.953 µM -0.961726939370052 0.167288815575016 no 2867 0.16809339319594 3916 3980186 SGTC_2523 spermine 47.74 µM -0.96253031713704 0.167084405319366 no 2868 0.167891640884501 4055 1103 A DNA binding polyamine. SGTC_761 k216-0224 480 µM -0.963079124218234 0.166944860279268 no 2869 0.167753908579811 4075 1340404 SGTC_2440 5628896 157.78 µM -0.963909654141753 0.166733824637292 no 2870 0.167545611630007 4038 5522048 SGTC_7 0192-1582 4.227 µM -0.964574119963779 0.1665651094833 no 2871 0.167379083590642 4076 252616 SGTC_207 4185-0010 4.486 µM -0.965424391150586 0.166349377091572 no 2872 0.16716614474283 4099 3761753 SGTC_1412 3909-8563 178 µM -0.967795329850458 0.165748771588309 no 2873 0.166573298326058 4116 23767530 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.97057163876785 0.165047262132936 no 2874 0.165880817374371 4055 616764 SGTC_1921 5740136 50 µM -0.972206232221393 0.164635138306346 no 2875 0.165473980368335 3988 1774243 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.973417650798417 0.16433013853531 no 2876 0.165172884938741 4070 7104 SGTC_2749 bexarotene 57.39 µM -0.973528424445892 0.164302267263115 no 2877 0.16514537009871 4096 82146 An retinoic acid receptor inhibitor. SGTC_1914 st062367 72.6 µM -0.974028117336914 0.164176579823839 no 2878 0.16502128928242 4049 978205 SGTC_848 0368-0089 85.6 µM -0.974350273878331 0.1640955810606 no 2879 0.164941325264856 4068 762535 SGTC_1347 1493-0251 600 nM -0.978720344393076 0.162999389900924 no 2880 0.163859088508669 4116 3986378 SGTC_847 0342-0274 5.54 µM -0.981357259850684 0.162340252599684 no 2881 0.163208297503352 4075 18097 SGTC_2541 muurolladie-3-one 83.07 µM -0.982650860262919 0.162017532651211 no 2882 0.162889651715081 4095 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2719 novobiocin 32.65 µM -0.984924448763905 0.161451344271186 no 2883 0.162330591556829 4079 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_827 3253-0474 693 µM -0.985054550839945 0.161418984217831 no 2884 0.162298638154892 4116 5402065 SGTC_1812 st052057 4.327 µM -0.985903387201733 0.161207958518073 no 2885 0.162090262289904 4097 3645418 SGTC_3135 9127742 49.47 µM -0.98644266623643 0.161073984122671 no 2886 0.161957968388451 4158 3643468 SGTC_1292 0kpi-0043 232 µM -0.986946892592701 0.160948783694879 no 2887 0.16183433712427 4087 3333905 SGTC_147 4466-0538 29.23 µM -0.987232349663997 0.160877932291982 no 2888 0.161764373170646 4165 6742687 YHR072W ERG7 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.987279201689018 0.16086630540764 no 2889 0.161752891881096 4090 5024745 SGTC_656 4090-1979 187 µM -0.987632722914066 0.160778592619237 no 2890 0.161666277111206 4140 22330961 SGTC_821 1114-0266 29.2 µM -0.987878027307375 0.160717748059426 no 2891 0.161606193868012 4103 3123235 SGTC_1105 epirubicin 18.1 µM -0.988946392602149 0.160452929338115 no 2892 0.161344685282527 4107 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1622 st003707 19.4 µM -0.98974608109504 0.1602548949653 no 2893 0.161149122640828 4101 10140899 SGTC_2181 6316240 54.2555 µM -0.993097193540685 0.159426765706727 no 2894 0.160331295765498 4104 12779990 SGTC_1564 D-Arginine 115 µM -0.994794946884488 0.159008286867172 no 2895 0.159918002195518 4098 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1429 4049-0205 9.46 µM -0.996552252178278 0.158575887821179 no 2896 0.159490946115759 4108 22774478 SGTC_2950 9072895 21.46 µM -0.997410141727459 0.158365077591742 no 2897 0.159282735306248 4055 17332245 SGTC_1029 k015-0030 64.7 µM -0.997536742127365 0.15833398349874 no 2898 0.159252024318378 4147 2208316 SGTC_798 1287-0182 476 µM -0.998672963644857 0.158055097513269 no 2899 0.158976570938018 4126 1649755 SGTC_3053 9095903 49.47 µM -1.00160096916272 0.157337904581239 no 2900 0.158268176360943 4183 17174018 SGTC_1656 st012921 11 µM -1.00180452788475 0.157288124061866 no 2901 0.158219004978719 4000 6732821 SGTC_1022 4477-0945 21.3 µM -1.00368087776934 0.156829748219111 no 2902 0.157766228480919 4049 4648966 SGTC_201 4262-0159 12.803 µM -1.00572181407597 0.156332164390429 no 2903 0.157274703371029 4129 1341029 SGTC_1431 4049-0260 9.09 µM -1.00609870326431 0.156240392015531 no 2904 0.157184046207628 4072 3854841 SGTC_2735 sertaconazole 140 nM -1.00724698192661 0.155961005427228 no 2905 0.156908050408198 4226 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3092 9117248 49.47 µM -1.00766198421845 0.155860112678485 no 2906 0.156808380556415 4192 17141857 SGTC_724 3910-0327 137 µM -1.00796665407402 0.155786070654839 no 2907 0.156735235439891 4159 2885483 SGTC_2081 5214970 32.255 µM -1.01302030932229 0.154561295538252 no 2908 0.155525230134803 4060 2063512 SGTC_1808 st050063 61.5 µM -1.0132815478653 0.154498156720316 no 2909 0.155462849305055 4091 4011993 SGTC_2227 7312221 64.1025 µM -1.01695875746396 0.153611220086917 no 2910 0.154586524763025 4190 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_774 k060-0086 136 µM -1.01798976563609 0.153363149053547 no 2911 0.154341409896828 4102 5911235 SGTC_81 0411-0046 9.971 µM -1.0182755430025 0.153294435121182 no 2912 0.154273513872256 4046 12925265 SGTC_2902 5787006 60.46 µM -1.01837805602726 0.153269791279313 no 2913 0.154249163269748 4074 591003 SGTC_2009 4012297 12.05 µM -1.01843471303875 0.153256172220022 no 2914 0.154235706242613 4121 45595307 SGTC_1000 4048-0884 8.67 µM -1.0199424000393 0.152894053075529 no 2915 0.153877889565092 4150 13040088 SGTC_810 3825-7150 143 µM -1.0206405510289 0.15272656217704 no 2916 0.153712384877713 4177 22330411 YGL099W LSG1 SGTC_1510 1123-0200 71.5 µM -1.02107684464217 0.152621954356509 no 2917 0.153609016336904 4174 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_627 1391-0720 175 µM -1.02150026991939 0.152520477371286 no 2918 0.153508740639556 4097 997839 SGTC_1804 st050076 49.1 µM -1.02175523275611 0.152459395250769 no 2919 0.153448381182912 4140 3895976 SGTC_2967 9089538 49.85 µM -1.02187556597758 0.152430572342709 no 2920 0.153419899167448 4136 728216 SGTC_2351 9026858 72.31 µM -1.02332171011432 0.152084466443047 no 2921 0.153077881101222 4017 1409300 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.0239270066109 0.151939755798753 no 2922 0.152934876548212 4157 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1905 st060207 84.5 µM -1.02428805649879 0.15185348173052 no 2923 0.152849618758123 4079 1948547 SGTC_2314 7727897 200 µM -1.02540380228288 0.151587076315853 no 2924 0.15258634741983 4129 900724 SGTC_2080 5212524 12.4 µM -1.02755288809081 0.151074817450701 no 2925 0.152080097527553 4006 260183 SGTC_3045 9092950 49.47 µM -1.02795573216153 0.150978923363002 no 2926 0.151985325758323 4058 44120432 SGTC_1157 4092-0394 27.6 µM -1.02868166897354 0.150806221702906 no 2927 0.151814643315875 4217 3659885 SGTC_2466 5983409 37.09 µM -1.02911257957857 0.150703769531385 no 2928 0.151713387770184 4134 2879657 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.0299479314282 0.150505290512473 no 2929 0.151517224326528 4078 6708514 SGTC_1486 3970-0793 4.53 µM -1.03178515416646 0.150069380537383 no 2930 0.151086387730772 4135 2844330 SGTC_2206 7254556 146.969 µM -1.03472517873059 0.149373566356072 no 2931 0.150398636914211 4126 4398905 SGTC_2160 5660466 132.927 µM -1.03548948251581 0.149193032244426 no 2932 0.150220187849214 4020 2859134 SGTC_3330 9141424 71.43 µM -1.03593795452287 0.149087167757632 no 2933 0.150115544669019 4207 27261020 SGTC_2816 7982706 58.44 µM -1.04107769395165 0.147877484706814 no 2934 0.148919745543598 4163 2981853 SGTC_2232 chlorophetanol 41.5365 µM -1.04144832411042 0.147790508359665 no 2935 0.148833762352135 4201 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1394 3474-0001 65.7 µM -1.0455935873723 0.146820067250987 no 2936 0.147874355609891 4142 5017666 YIL048W NEO1 SGTC_879 0831-1030 162 µM -1.04615622088159 0.146688680230824 no 2937 0.147744455890138 4161 1549252 SGTC_1514 1189-1591 158 µM -1.04626150760615 0.14666410228304 no 2938 0.147720155988279 4155 767698 YMR146C TIF34 SGTC_2393 9031399 185.94 µM -1.04782090375038 0.146300403149196 no 2939 0.147360564809506 4192 1526623 YDL150W RPC53 SGTC_2426 5582046 32.21 µM -1.05484029144854 0.144670769477174 no 2940 0.14574918689258 4162 2251934 SGTC_894 0960-0238 55.9 µM -1.05494556965272 0.144646421332302 no 2941 0.145725109620475 4149 6741907 YDL195W SEC31 SGTC_1704 st028805 70.8 µM -1.05971611124912 0.143546013645924 no 2942 0.144636885450021 4189 2876101 SGTC_2322 7413319 38.22 µM -1.0597293263584 0.143542973222566 no 2943 0.144633878530428 4184 1840400 SGTC_1563 conessine 56.1 µM -1.0616622784623 0.143098723694083 no 2944 0.144194514896094 4233 441082 An anti-amoebic, histamine inhibitor. SGTC_3003 9075612 71.4286 µM -1.06182253140358 0.143061934572344 no 2945 0.144158129537777 4181 6501993 SGTC_1729 st035615 45.989 µM -1.06359785495297 0.142654802685397 no 2946 0.143755457280747 4187 17385451 SGTC_170 4197-0004 226 µM -1.06535498363326 0.142252615507764 no 2947 0.143357659899046 4181 218692 SGTC_725 1497-0963 19 µM -1.06535823074286 0.142251872991494 no 2948 0.143356925472752 4271 3549977 SGTC_54 0159-0055 9 µM -1.06721988020069 0.141826601500938 no 2949 0.142936278687902 4175 3319099 SGTC_1479 0549-0158 134 µM -1.06762684873937 0.141733749217354 no 2950 0.142844433811289 4204 5440202 SGTC_318 1488-0629 67.2 µM -1.07314385436184 0.140479073943295 no 2951 0.141603288607802 4205 3662576 SGTC_450 aminopyrene 156 nM -1.07336413430373 0.140429135000833 no 2952 0.141553884992809 4094 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_231 b-estradiol 524 µM -1.0772598350017 0.139547944913673 no 2953 0.140682100307965 4159 450 A steroid. SGTC_2839 9003951 25.97 µM -1.07871064724752 0.139220740743461 no 2954 0.140358368882243 4225 2990634 SGTC_1426 4048-4480 71.7 µM -1.08032615907761 0.13885700640867 no 2955 0.13999848241912 4172 14224343 SGTC_1279 0874-0590 65.2 µM -1.08154357621012 0.138583331495692 no 2956 0.139727693892372 4234 3523074 SGTC_512 prima-1 270 µM -1.08569707340058 0.137652393861834 no 2957 0.138806517958614 4188 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2310 7668677 200 µM -1.08924149656737 0.136861352576659 no 2958 0.138023702058003 4200 2197143 SGTC_2560 caryophyllene 100 µM -1.0894845614385 0.136807219643458 no 2959 0.137970129662299 4224 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3011 9081274 71.4286 µM -1.0900162561001 0.136688857052353 no 2960 0.137852991645245 4183 6625322 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.09049173051025 0.136583069186415 no 2961 0.137748297034064 4131 97141 SGTC_990 3985-0011 41.3 µM -1.09105988064743 0.136456735422326 no 2962 0.137623267341432 4163 5399565 YGL099W LSG1 SGTC_1064 honokiol 6.76 µM -1.09407544082572 0.13578753416788 no 2963 0.136960946308391 4197 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2043 5101342 149 µM -1.0963053735263 0.135294124141521 no 2964 0.136472579305151 4197 678451 SGTC_2841 9004761 38.96 µM -1.09807618356776 0.134903179235575 no 2965 0.136085612055748 4165 2991039 SGTC_23 0213-0011 39.996 µM -1.10382495050106 0.133639358545389 no 2966 0.134834539699237 4202 627608 SGTC_334 1502-1024 68.5 µM -1.10403296688132 0.133593780924989 no 2967 0.134789418656279 4203 3296216 SGTC_1993 st073995 70.8 µM -1.10525810118018 0.133325563616753 no 2968 0.134523883737904 4178 3098394 SGTC_1336 1486-0901 104 µM -1.10540481312874 0.133293468987589 no 2969 0.134492109565137 4222 5006114 SGTC_2519 cryptotanshinone 88.04 µM -1.10597115657304 0.133169625859303 no 2970 0.134369501942542 4178 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1134 3477-0009 42.5 µM -1.11225692566126 0.131800423673128 no 2971 0.133013849194831 4284 3973534 SGTC_2231 micatex 6.853 µM -1.11360351250665 0.131508370143948 no 2972 0.132724659442287 4222 20737 An antifungal of unknown mechanism. SGTC_918 glabranin 770.725 nM -1.11441447803972 0.131332700146139 no 2973 0.132550707510571 4215 124049 Also referred to as licorice root. SGTC_2983 9022671 12.99 µM -1.11476875277383 0.131256008623256 no 2974 0.132474764975966 4208 6405161 SGTC_291 SEC14.278 35.5 µM -1.11506773509674 0.131191310578119 no 2975 0.132410698285887 4258 1068044 SGTC_87 0100-0052 35.5 µM -1.11542040229841 0.131115023754115 no 2976 0.132335155315205 4246 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1346 1488-2224 62.4 µM -1.11567825225944 0.131059266615374 no 2977 0.132279941445415 4222 3722427 SGTC_1405 3909-7894 12 µM -1.11750033314968 0.130665729089867 no 2978 0.131890228609448 4206 7104060 SGTC_3192 9110362 49.47 µM -1.11892294705465 0.130359037911808 no 2979 0.131586506220946 4237 16649480 SGTC_809 3998-0021 90 µM -1.11921282982927 0.130296605273929 no 2980 0.131524676658057 4161 715485 SGTC_313 3474-0040 5.03 µM -1.121818167399 0.129736416855933 no 2981 0.130969880047643 4216 1043375 YIL048W NEO1 SGTC_1966 st070145 16.1 µM -1.12225309697195 0.129643062883994 no 2982 0.130877421204584 4193 3748532 SGTC_1679 SEC14.276 6.7 µM -1.12226369241824 0.129640789241329 no 2983 0.130875169350692 4218 1005053 YMR079W SEC14 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.12551680171409 0.128944020686343 no 2984 0.130185050753037 4196 364106 SGTC_1299 1079-1439 3.74 µM -1.12705617940629 0.128615215343566 no 2985 0.129859364539827 4182 323161 SGTC_3104 9120930 49.47 µM -1.1307715701367 0.127824020003346 no 2986 0.129075624420956 4247 17014836 SGTC_377 3970-0964 33.1 µM -1.13517699346353 0.126890272727098 no 2987 0.128150583505246 4172 16481235 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.13521890843649 0.126881411542463 no 2988 0.128141804462405 4268 5393153 SGTC_2251 lansoprazole 556 µM -1.13569677436638 0.126780417039175 no 2989 0.12804174552099 4149 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_989 1501-0895 10.3 µM -1.13656690513299 0.126596663162322 no 2990 0.127859690818668 4195 2830112 SGTC_2641 levomentholum 100 µM -1.14164119743556 0.125528771432426 no 2991 0.126801596123218 4226 16666 SGTC_2044 5102272 200 µM -1.14266396736628 0.125314291572376 no 2992 0.126589067842907 4228 592666 SGTC_1892 st058411 7.36 µM -1.14394910542967 0.125045154708006 no 2993 0.126322372224072 4249 3934738 SGTC_2895 9054447 58.44 µM -1.14509465008663 0.124805592404802 no 2994 0.126084975708353 4300 2697450 SGTC_3101 9120531 49.47 µM -1.14515874831765 0.124792197327647 no 2995 0.126071701530217 4254 24824904 SGTC_927 2425-1185 123 µM -1.14564457597309 0.124690703024978 no 2996 0.125971122586517 4171 730375 SGTC_2306 7482397 179.52 µM -1.14776509832399 0.124248380016927 no 2997 0.125532774521719 4250 891448 SGTC_1662 st014054 52 µM -1.15055256521269 0.123668609307948 no 2998 0.124958178572104 4281 2838777 SGTC_697 0508-1955 564 µM -1.15239339153135 0.123286772346781 no 2999 0.124579727673242 4242 6243113 SGTC_1389 3405-0187 19 µM -1.15451391068438 0.122847944365168 no 3000 0.1241447694068 4208 799890 SGTC_121 0557-0495 61.343 µM -1.15481158286096 0.122786430778188 no 3001 0.124083796400838 4325 3104427 SGTC_1605 st000082 49.1 µM -1.15667233692556 0.122402397816156 no 3002 0.123703127918241 4200 1114022 SGTC_508 roscovitine 141 µM -1.15925180552797 0.121871427902609 no 3003 0.12317678013941 4315 160355 A CDKinase inhibitor. SGTC_18 0111-0177 500 nM -1.1607269469988 0.121568506128088 no 3004 0.122876479832137 4329 721752 SGTC_149 3970-0822 46.1 µM -1.16147477785139 0.121415140629254 no 3005 0.122724437240757 4236 3114250 YBL034C STU1 SGTC_922 1866-0035 480 µM -1.16239617543633 0.121226367098576 no 3006 0.122537288054801 4173 3156169 SGTC_3124 9127567 49.47 µM -1.16289504822075 0.121124245525236 no 3007 0.122436043372583 4236 17592030 SGTC_746 1095-0025 46.6 µM -1.16455286747882 0.120785316970088 no 3008 0.122100015839583 4272 6749286 SGTC_1707 st032323 6.317 µM -1.16469846701869 0.120755582169275 no 3009 0.122070534869589 4114 3132057 YMR211W DML1 SGTC_1900 st060200 72.8 µM -1.16681695293857 0.120323521055985 no 3010 0.12164214960632 4243 688945 SGTC_3209 9113616 49.47 µM -1.16828346204589 0.120025067926945 no 3011 0.121346221999022 4312 16649353 SGTC_3082 9117008 49.47 µM -1.17165753923776 0.119340382847575 no 3012 0.120667288422824 4302 41448529 SGTC_1282 0886-0010 32.4 µM -1.17461320307129 0.118742873027569 no 3013 0.120074749326381 4294 2836211 YNL267W PIK1 SGTC_2280 7785178 200 µM -1.17517581092697 0.118629377434945 no 3014 0.119962192774396 4250 2954328 SGTC_1948 st076329 66.6 µM -1.18119217501714 0.117420479591421 no 3015 0.118763194548221 4181 24208413 SGTC_2253 7938677 135.83 µM -1.18386624026347 0.116885976182066 no 3016 0.118233007916615 4332 2301972 SGTC_2683 piperine 63.03 µM -1.18398916355616 0.116861447284554 no 3017 0.118208676227258 4250 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_215 1287-0124 461.5 µM -1.18628151239407 0.116404685715481 no 3018 0.117755572564684 4284 5560863 SGTC_2987 9018338 71.43 µM -1.18692207616039 0.116277276992105 no 3019 0.117629179294491 4295 5055682 SGTC_2092 5303694 80.6725 µM -1.18740168063167 0.116181948020897 no 3020 0.117534608703144 4262 1963699 SGTC_681 1642-0006 26.6 µM -1.18977323841526 0.115711378648867 no 3021 0.117067765335644 4284 4446530 SGTC_258 haloperidol 50.781 µM -1.19022052381115 0.115622779313017 no 3022 0.116979864259964 4281 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2297 7971671 152.32 µM -1.19037068654992 0.115593045535285 no 3023 0.116950364583839 4290 909016 SGTC_479 n-linoleoylglycine 10 µM -1.19092955957145 0.115482430620374 no 3024 0.116840619538175 4324 6433346 An anti-infammatory. SGTC_3079 9117512 49.47 µM -1.19191618042708 0.115287337373309 no 3025 0.116647056529887 4334 7185044 SGTC_1619 st003326 88.7 µM -1.19293006448158 0.115087097325928 no 3026 0.116448381819457 4269 2849032 SGTC_2283 7944793 200 µM -1.1996585452564 0.113764501019986 no 3027 0.115135989556138 4300 2970533 SGTC_122 0236-0016 402.397 µM -1.20631008220726 0.112467712907165 no 3028 0.113848975809143 4278 6808838 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.20716053114351 0.112302673288373 no 3029 0.113685163584409 4310 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3276 9139060 49.47 µM -1.20801323350049 0.112137370192528 no 3030 0.113521086065671 4399 4870619 SGTC_1834 st055981 52.8 µM -1.2081584171918 0.112109242521997 no 3031 0.113493166560244 4294 471719 YDL150W RPC53 SGTC_3352 9151559 45.5865 µM -1.20864188002165 0.112015613520136 no 3032 0.113400229690157 4286 17159339 SGTC_3224 9130643 49.47 µM -1.20986691886963 0.111778618806905 no 3033 0.113164981466038 4364 17644395 SGTC_2917 7979103 53.79 µM -1.21110822189281 0.11153884367973 no 3034 0.112926965358609 4318 2980565 SGTC_1714 st033236 13.627 µM -1.21460119934649 0.110866101563389 no 3035 0.112259115609481 4331 2916566 SGTC_401 neomycin 50 µM -1.21480955695079 0.110826064278027 no 3036 0.112219367481518 4271 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2767 sibutramine 71.45 µM -1.21632239794167 0.110535672569968 no 3037 0.111931066271247 4332 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1687 st020778 55.3625 µM -1.21638362618713 0.110523931227292 no 3038 0.111919409202539 4307 4259299 SGTC_228 caffeine 993.056 µM -1.22198644322231 0.109453296711139 no 3039 0.110856376841689 4306 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2465 5809242 33.21 µM -1.22225846654373 0.109401506413941 no 3040 0.110804950134939 4349 2731748 SGTC_1738 st035555 74 µM -1.22364736583138 0.109137349379472 no 3041 0.110542641600822 4342 5331140 SGTC_284 0988-0104 32.6 µM -1.22592815761648 0.108704556741917 no 3042 0.110112855785629 4276 4666532 SGTC_1084 voriconazole 435 nM -1.22740522528855 0.10842493442473 no 3043 0.109835161719701 4318 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1741 st038134 10.228 µM -1.22949487145376 0.108030229982845 no 3044 0.109443159763364 4370 1272587 SGTC_2394 5221648 200 µM -1.2355402386399 0.106894174547981 no 3045 0.108314755227512 4339 788586 SGTC_2266 7929956 200 µM -1.23593828913458 0.106819675825163 no 3046 0.108240751565811 4260 2967153 SGTC_869 0564-0080 44.1 µM -1.23653781497214 0.10670753990151 no 3047 0.108129359256759 4321 6843321 SGTC_2521 angolensin 13.4 µM -1.23701937130847 0.106617530657578 no 3048 0.108039945544284 4361 821428 A flavenoid. SGTC_1263 0774-1208 64.8 µM -1.23775994251002 0.106479215077778 no 3049 0.107902542755028 4352 906585 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.23814609393658 0.106407145455072 no 3050 0.107830947613081 4351 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_808 0711-0032 135 µM -1.23934681833589 0.10618327253221 no 3051 0.107608543639877 4292 4252555 SGTC_1184 1269-1718 139 µM -1.24103445573156 0.105869191018384 no 3052 0.107296510324661 4367 5403821 SGTC_3052 9092717 49.47 µM -1.24316494700364 0.10547365080062 no 3053 0.106903528402326 4325 25237534 SGTC_2040 5100729 123 µM -1.24513865191768 0.105108173784514 no 3054 0.106540394214933 4339 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1274 0865-0114 173 µM -1.24680106707679 0.104801051072085 no 3055 0.106235224573277 4324 870624 SGTC_308 4092-1169 104 µM -1.24734360726111 0.104700960324468 no 3056 0.106135767222021 4274 2268590 YDL196W YDL196W SGTC_1121 fusaric acid 630.51 nM -1.25002536854517 0.104207231306692 no 3057 0.105645140198748 4294 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1843 st055809 45.5 µM -1.25543239779921 0.103216899574328 no 3058 0.104660917262388 4388 16413835 SGTC_1574 spiramycin 23.7 µM -1.25602039244844 0.103109618015969 no 3059 0.104554288324921 4290 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2513 baicalein 25.65 µM -1.25602827570821 0.103108180239648 no 3060 0.104552859282766 4326 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1631 benzylvanillin 81.9 µM -1.2565050995879 0.103021242516617 no 3061 0.104466449087056 4380 75506 SGTC_3091 9116372 49.47 µM -1.25788285724503 0.102770339739601 no 3062 0.104217062130275 4389 17169793 SGTC_1345 1488-0192 31.4 µM -1.25890723151133 0.102584079468029 no 3063 0.104031920762814 4378 658348 SGTC_2563 tomatine 8.54 µM -1.26178672834361 0.102061820021774 no 3064 0.103512769515141 4306 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1852 st056254 31.4 µM -1.26243473824719 0.101944556454903 no 3065 0.103396197911799 4284 442583 SGTC_2994 9053520 71.4286 µM -1.26389664322582 0.101680370996306 no 3066 0.103133563398393 4379 4647384 SGTC_1378 2093-0007 380 nM -1.2647936526994 0.101518516546189 no 3067 0.102972653658873 4389 3618014 SGTC_3267 9137951 49.47 µM -1.26518522308871 0.101447921294729 no 3068 0.102902469149337 4385 16643986 SGTC_1186 1319-0216 26 µM -1.26617250760645 0.101270084976814 no 3069 0.102725664002785 4412 4565136 SGTC_1864 st057645 30.4 µM -1.26789613830184 0.100960157661747 no 3070 0.102417521678392 4380 688666 SGTC_1660 st012960 28.1 µM -1.27198485524344 0.100227729252833 no 3071 0.101689250151941 4374 24207266 SGTC_2941 9056145 11.23 µM -1.27221044310886 0.100187431981195 no 3072 0.101649179067668 4271 2119517 SGTC_706 4262-0057 46.9 µM -1.27530769226857 0.09963535882781 no 3073 0.101100178067652 4340 883298 SGTC_305 1682-2595 20.8 µM -1.28029906420803 0.0987503484583724 no 3074 0.100219988347186 4366 226033 SGTC_1680 diphenhydramine 100 µM -1.28060324350709 0.0986966015994834 no 3075 0.100166530084238 4319 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2267 7931562 200 µM -1.28073137455686 0.0986739679367502 no 3076 0.1001440178106 4292 934880 SGTC_3054 9094397 49.47 µM -1.28263047319806 0.0983389476767454 no 3077 0.0998107843853009 4348 2598354 SGTC_82 0054-0107 293.755 µM -1.28575730176997 0.0977891595899603 no 3078 0.0992638880360538 4308 3104697 SGTC_1777 st045864 34.765 µM -1.28709408906787 0.0975548020274359 no 3079 0.0990307477272562 4338 4691462 SGTC_350 k064-0020 19.8 µM -1.28762885887564 0.0974611648153931 no 3080 0.0989375942821604 4375 2790705 SGTC_2211 7117706 200 µM -1.28766127493235 0.0974554909432161 no 3081 0.0989319496759559 4282 822771 SGTC_2006 4011487 200 µM -1.28767716725485 0.0974527093545065 no 3082 0.0989291824327658 4351 45595294 SGTC_2213 7173844 200 µM -1.28830371831211 0.0973430922772425 no 3083 0.0988201296452373 4351 892728 SGTC_3023 9089636 49.47 µM -1.28909423817843 0.0972049174394729 no 3084 0.0986826632150222 4417 17249241 SGTC_90 0870-0863 4.608 µM -1.28989836713412 0.0970645115895117 no 3085 0.0985429739002556 4369 1738164 SGTC_328 k915-0120 63.5 µM -1.29275701632315 0.0965665791267064 no 3086 0.0980475555433492 4365 6624543 SGTC_3015 9080845 49.47 µM -1.29582965409311 0.0960334683899793 no 3087 0.0975170895814208 4407 5296973 SGTC_1390 3413-2614 145 µM -1.29619496507107 0.095970230198253 no 3088 0.0974541618780111 4371 3421432 SGTC_641 4092-0595 30 µM -1.3037124498258 0.0946756860849473 no 3089 0.0961658214781211 4416 786260 SGTC_845 0330-0138 4.51 µM -1.30507226991374 0.0944429001589157 no 3090 0.095934120074742 4315 9039800 SGTC_282 k297-0036 65.7 µM -1.30631528762311 0.0942304789510633 no 3091 0.0957226801892138 4377 5061378 SGTC_1012 4112-3522 18 µM -1.3080931651758 0.0939272675335039 no 3092 0.0954208557077906 4377 3112398 SGTC_2848 9016370 25.97 µM -1.3089417143696 0.0937828042469277 no 3093 0.0952770474882129 4365 7894410 SGTC_701 4424-0219 185 µM -1.31001710744086 0.0935999571191958 no 3094 0.0950950241594551 4392 2911779 SGTC_2453 5731132 22.18 µM -1.31031209695466 0.0935498466286777 no 3095 0.0950451383972122 4414 1362040 SGTC_2849 9019321 12.99 µM -1.31084985784462 0.093458547036623 no 3096 0.0949542471010144 4398 16489627 SGTC_2713 st079149 53.4 µM -1.31687994946256 0.092439277412099 no 3097 0.093939434182376 4406 3103253 SGTC_2612 dictamnine 15.46 µM -1.31764907355815 0.0923098657019811 no 3098 0.0938105749073761 4299 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3323 9138564 53.9225 µM -1.32066369013097 0.0918039233050007 no 3099 0.0933067630522415 4389 43912313 YNL103W MET4 SGTC_2326 6164455 177.58 µM -1.32226338382905 0.0915362827077064 no 3100 0.0930402305867866 4339 2888790 SGTC_174 3553-0389 74.3 µM -1.32625185164493 0.0908715014049266 no 3101 0.0923781447056326 4437 738071 SGTC_1447 4239-0816 81.9 µM -1.32869852543883 0.0904654764980332 no 3102 0.0919737258085348 4392 1341554 SGTC_995 3931-2021 34.6 µM -1.3304644773108 0.0901732552674864 no 3103 0.091682641422825 4389 730143 SGTC_408 cantharidin 100 µM -1.3342599554411 0.0895475718318713 no 3104 0.0910593382303393 4357 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1845 st056753 3.01 µM -1.33650394108528 0.0891791733130155 no 3105 0.0906923066015049 4363 5375839 SGTC_1954 st077032 68.9 µM -1.33780904820459 0.0889654312602067 no 3106 0.0904793457874336 4341 698907 SGTC_2164 5685496 200 µM -1.34010695724425 0.0885900217121579 no 3107 0.0901052872696161 4314 759046 SGTC_88 0180-0332 8.668 µM -1.34243592585551 0.0882107432889717 no 3108 0.0897273463447949 4489 3101745 SGTC_2261 9010538 184.68 µM -1.34324159782367 0.0880798197443436 no 3109 0.0895968780571554 4390 6457250 SGTC_1796 st049173 110.4 µM -1.34419073278553 0.0879257690666738 no 3110 0.0894433588121352 4375 94134 SGTC_712 r015-0009 80.6 µM -1.34445422172125 0.0878830387801118 no 3111 0.0894007751191968 4423 6813872 YLR060W FRS1 SGTC_1185 1319-0113 81.3 µM -1.34539018935817 0.0877313771111817 no 3112 0.0892496308921768 4463 4672763 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.34748087724199 0.0873933129938984 no 3113 0.0889127040861385 4391 1377 SGTC_2305 7443522 69.23 µM -1.34827919234719 0.0872644823455349 no 3114 0.0887843009799369 4292 5415886 SGTC_1348 1493-0373 93.8 µM -1.35011570373189 0.0869686478395206 no 3115 0.0884894359371601 4427 3010129 SGTC_2565 isoliquiritigenin 100 µM -1.35069599284878 0.0868753278769369 no 3116 0.0883964182222841 4425 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_576 1073-0113 22.7 µM -1.35316878306085 0.0864785013882009 no 3117 0.0880008578120678 4507 5439563 SGTC_1319 1306-0155 43.7 µM -1.35808645679496 0.0856933566983311 no 3118 0.0872181260435397 4451 3122360 SGTC_1113 artemisinin 1.17947 µM -1.36146722756396 0.0851566941113204 no 3119 0.0866830417237839 4449 2240 An anti-malaria and mitochondrial poison. SGTC_3211 9128781 49.47 µM -1.36404189681986 0.0847496841332586 no 3120 0.0862771899248607 4355 17194361 SGTC_1427 4048-4900 550 nM -1.36520489221431 0.0845663140008559 no 3121 0.0860943305885189 4406 24132586 SGTC_2905 7799065 20.05 µM -1.36602184356747 0.0844376828915362 no 3122 0.0859660537017634 4293 1296806 SGTC_1452 4194-0072 190 µM -1.36642183201954 0.084374757229999 no 3123 0.0859033000925063 4477 1343545 SGTC_1268 0828-0275 2.46 µM -1.36830359446272 0.0840791929251358 no 3124 0.08560853307098 4452 745337 SGTC_2810 7959871 45.46 µM -1.36852496705476 0.0840444735804692 no 3125 0.0855739062046104 4371 2974535 SGTC_1017 4239-0030 168 µM -1.36885765155236 0.0839923166901382 no 3126 0.0855218877731487 4435 1149593 SGTC_655 k060-0012 42 µM -1.37097766591853 0.083660520434506 no 3127 0.0851909591939599 4400 5994525 SGTC_977 1348-1378 135 µM -1.37140646319807 0.0835935307190092 no 3128 0.0851241419025853 4399 X977 SGTC_1788 fluconazole 20 µM -1.37234066460417 0.0834477228020046 no 3129 0.08497870606444 4424 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_96 0929-0093 37.281 µM -1.37905776547802 0.0824049571526736 no 3130 0.0839384721313816 4424 6991579 SGTC_2047 4141938 200 µM -1.38369896165562 0.0816902078443013 no 3131 0.0832253258239244 4437 3807862 SGTC_3110 9122132 49.47 µM -1.38421681455552 0.081610748652293 no 3132 0.0831460381259476 4457 918317 SGTC_534 k292-0788 63.4 µM -1.38687692916871 0.0812034997537832 no 3133 0.0827396469597042 4470 4146317 SGTC_2911 7942208 15.64 µM -1.39012264247988 0.0807086780138035 no 3134 0.082245819358919 4439 1243384 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.39111390736573 0.0805580106056167 no 3135 0.082095444129215 4381 676296 Flavone; oxidizing agent. SGTC_2783 7738165 71.43 µM -1.39156869569284 0.080488956146488 no 3136 0.0820265219340712 4410 17201110 SGTC_517 1365-0151 113 µM -1.3962510478577 0.0797805922233164 no 3137 0.0813194546534611 4433 768657 SGTC_1177 0983-0204 23.6 µM -1.40200463113082 0.0789166376484699 no 3138 0.0804569318825798 4455 766818 SGTC_132 0417-1715 25.805 µM -1.40326263044255 0.0787286849490485 no 3139 0.0802692686820555 4422 6769098 SGTC_483 fpl-64176 144 µM -1.40427005331997 0.078578414626957 no 3140 0.0801192241277106 4562 3423 SGTC_2992 9074591 71.4286 µM -1.40429160232449 0.0785752026871151 no 3141 0.080116016958229 4382 17741321 SGTC_593 1203-0218 61.7 µM -1.40467502076176 0.0785180697250795 no 3142 0.0800589684626992 4480 3666956 SGTC_895 0964-0006 13.7 µM -1.40628372474262 0.0782787008656484 no 3143 0.0798199455081803 4432 6738897 SGTC_1986 st071812 45 µM -1.40909930553216 0.0778610859495604 no 3144 0.0794029030941305 4377 11838594 SGTC_2425 5628681 7.85 µM -1.41083605731336 0.0776043304663721 no 3145 0.0791464799427905 4498 5714958 SGTC_2673 kobusone 100 µM -1.41209519280451 0.0774185864924821 no 3146 0.0789609670146117 4543 6710676 An epoxy ketone and protein crosslinker. SGTC_997 3996-0078 137 µM -1.41323017055713 0.0772514474316441 no 3147 0.078794029108659 4486 735687 SGTC_360 0957-0399 1.01 µM -1.41344511227252 0.0772198255875589 no 3148 0.0787624446013753 4453 6752301 YPR165W RHO1 SGTC_2468 5987765 72.9 µM -1.41542298014724 0.0769293066242936 no 3149 0.0784722579019674 4493 26772094 SGTC_2205 7238770 200 µM -1.41576093144833 0.0768797498927465 no 3150 0.0784227559063428 4491 279867 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.41787828988078 0.0765698154417953 no 3151 0.0781131508979081 4435 6312947 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.41905548801003 0.0763979112384559 no 3152 0.0779414198127557 4455 2346 DNA damaging agent; causes G2/M arrest. SGTC_2254 7938975 95.19 µM -1.42796510008914 0.0751063641750619 no 3153 0.076650952015997 4492 2969277 SGTC_3268 9137683 49.47 µM -1.43048582935934 0.0747439953087671 no 3154 0.0762888150280748 4519 1953228 SGTC_1196 1588-0294 184 µM -1.43328886029293 0.0743426122184915 no 3155 0.0758876520742149 4490 6144269 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.43531283521587 0.0740538116894937 no 3156 0.0755989859251565 4433 442882 SGTC_1392 3455-1037 33.9 µM -1.43677589261175 0.0738455826367274 no 3157 0.0753908412303715 4447 981132 SGTC_1957 st077035 62.4 µM -1.43716046751172 0.0737909225086166 no 3158 0.0753362015007741 4482 705593 SGTC_188 3229-0966 278.469 µM -1.43797025409264 0.0736759276128407 no 3159 0.0752212471447715 4513 5722370 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.45411479168566 0.0714117890246034 no 3160 0.0729572416453244 4383 17037758 SGTC_533 1222-0222 6.71 µM -1.45581780631117 0.0711761034025999 no 3161 0.0727214960105828 4490 3982874 SGTC_3066 9117245 49.47 µM -1.45597721495971 0.0711540729363002 no 3162 0.0726994592122184 4515 17176980 SGTC_644 1498-1197 63.3 µM -1.45696727162624 0.0710173631441533 no 3163 0.0725627073587015 4502 6741615 SGTC_2878 9043973 25.97 µM -1.457768531229 0.0709068707486955 no 3164 0.0724521774789173 4486 6465167 SGTC_34 0469-0683 81.75 µM -1.45811270284494 0.0708594506066541 no 3165 0.0724047402914203 4437 3690923 SGTC_1984 st072354 53.1 µM -1.46304790191347 0.0701821528884309 no 3166 0.0717271359866972 4353 5762938 SGTC_2798 7813637 45.45 µM -1.4637832566107 0.070081661820849 no 3167 0.0716265893287667 4460 956368 SGTC_1583 clindamycin 39.6 µM -1.46534798655431 0.0698681995601222 no 3168 0.0714130002702238 4443 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_921 1561-0023 372 µM -1.4656966279817 0.0698207057299947 no 3169 0.0713654766135922 4453 24050882 SGTC_186 3455-3465 67.277 µM -1.4716869627358 0.0690085456180394 no 3170 0.0705527148954677 4481 755278 SGTC_3027 9089541 49.47 µM -1.47619032270814 0.0684027964287706 no 3171 0.0699464033508612 4470 9943819 SGTC_1200 1643-0193 18.4 µM -1.47796030027256 0.0681658420621708 no 3172 0.0697092023152344 4498 5403974 SGTC_3293 9120939 62.045 µM -1.47836980784641 0.0681111099118642 no 3173 0.0696544110432983 4465 934087 SGTC_2484 5809818 12.04 µM -1.49090589379858 0.0664519797457848 no 3174 0.0679931018886139 4468 2870548 SGTC_2358 9037157 4 µM -1.49114223674436 0.0664210033820659 no 3175 0.0679620776435293 4495 2388925 SGTC_381 3461-2219 42.7 µM -1.49222677589689 0.0662790012520302 no 3176 0.0678198525987943 4459 2883159 SGTC_3048 9093155 49.47 µM -1.49250506641299 0.0662426017292274 no 3177 0.0677833950316822 4457 25236002 SGTC_1636 st007707 68.9 µM -1.49338761060321 0.0661272701276071 no 3178 0.0676678770754259 4501 403051 SGTC_2603 homopterocarpin 100 µM -1.49354406105265 0.0661068412950199 no 3179 0.0676474148462089 4469 101795 A weak amylase inhibitor. SGTC_456 gingerol 170 µM -1.49860399011341 0.065448763437225 no 3180 0.0669881984934355 4516 442793 A herb. SGTC_881 0833-0569 170 µM -1.49985807808432 0.0652864491568501 no 3181 0.0668255846107677 4522 5418700 SGTC_3100 9120536 49.47 µM -1.5000315694924 0.0652640190967322 no 3182 0.0668031125609167 4386 16421196 SGTC_2165 5727197 32.143 µM -1.50654367779509 0.0644264091638237 no 3183 0.065963831712714 4545 1361712 SGTC_89 0302-0250 142.109 µM -1.50741023722839 0.0643155818195557 no 3184 0.0658527681773528 4571 4203518 YLR208W SEC13 SGTC_1958 st076513 41.9 µM -1.50842894648789 0.0641854850229437 no 3185 0.0657223895875729 4435 732122 YGL099W LSG1 SGTC_128 0906-2981 13.371 µM -1.51479619169647 0.0633769698736699 no 3186 0.0649120126053123 4484 6740226 SGTC_193 1273-0060 1.558 µM -1.51669834048749 0.063136978606313 no 3187 0.0646714317466171 4350 2847393 YHR072W ERG7 SGTC_762 1165-0429 115 µM -1.52572991588264 0.0620071235662129 no 3188 0.0635385704698517 4502 5967793 SGTC_1344 1488-0097 29.1 µM -1.52640992298801 0.0619226971142386 no 3189 0.0634539039672922 4532 747966 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.53029513889094 0.0614420465841939 no 3190 0.0629718454979874 4500 803109 SGTC_2643 anethole 100 µM -1.53215292718169 0.0612132468673652 no 3191 0.0627423507582578 4518 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2366 9070441 60.58 µM -1.53689789157328 0.0606318926727121 no 3192 0.0621591579621214 4492 6837235 SGTC_985 1493-0307 8.71 µM -1.53756672621869 0.0605502953357684 no 3193 0.0620772941720668 4555 3278274 SGTC_620 0109-0052 432 µM -1.54206243979412 0.0600040491245748 no 3194 0.0615292105724327 4564 493037 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.54518917810207 0.059626419321122 no 3195 0.061150255605558 4513 5377381 SGTC_2598 perillyl alcohol 100 µM -1.546901233128 0.0594204374557572 no 3196 0.0609435318381364 4518 10819 An apoptosis inducer. SGTC_1182 1222-0449 220 µM -1.55204381584784 0.0588050728801306 no 3197 0.060325869972156 4521 658318 SGTC_1875 nocodazole 6 µM -1.55335012981572 0.0586495578608661 no 3198 0.0601697550670148 4541 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_952 1185-0122 232 µM -1.55443348614983 0.0585208307193929 no 3199 0.0600405254397273 4473 678600 SGTC_1236 0330-0013 258 µM -1.55668242786693 0.0582543141126252 no 3200 0.0597729513433506 4549 4617066 SGTC_2340 7987427 183.45 µM -1.55718470567135 0.0581949208489821 no 3201 0.0597133192577643 4518 2239331 SGTC_1936 st074407 74.3 µM -1.55923341411427 0.0579531581418822 no 3202 0.0594705724819648 4550 809813 SGTC_699 0375-0592 111 µM -1.56481950833594 0.0572979676080289 no 3203 0.0588126180872307 4598 762578 SGTC_399 oxolinic acid 75 µM -1.56558663175732 0.0572084490354399 no 3204 0.0587227108105653 4503 4628 A DNA gyrase inhibitor. SGTC_2229 7354935 190 µM -1.56841429040899 0.0568794290462962 no 3205 0.0583922391046066 4515 318112 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.57223284627783 0.0564374775972047 no 3206 0.0579482802501064 4564 688664 SGTC_1911 st060208 74.3 µM -1.57625061027065 0.0559753967176041 no 3207 0.0574840295270471 4541 688783 SGTC_1467 k284-1082 293 µM -1.58686603517277 0.0547688747261416 no 3208 0.056271494447925 4514 3334705 SGTC_1554 st069299 38.7 µM -1.59692533712615 0.0536446206182418 no 3209 0.0551411755865358 4495 24207999 SGTC_3175 9106517 49.47 µM -1.60188877876365 0.0530966690209034 no 3210 0.0545901031549533 4567 41468073 SGTC_2803 7707263 71.43 µM -1.60666506143113 0.0525735785581488 no 3211 0.054063930930121 4507 2199229 SGTC_415 dibenzyl ketone 100 µM -1.61023558178765 0.0521852192762761 no 3212 0.0536732181495157 4528 7593 SGTC_1530 rhein 70.4 µM -1.61338866110758 0.051844161967532 no 3213 0.0533300475193501 4634 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_392 N-ethylmaleimide 8.33 µM -1.61637976903404 0.0515222640920423 no 3214 0.053006114846664 4520 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2526 patulin 37.61 µM -1.61936774619586 0.0512022919881932 no 3215 0.052684081138552 4556 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1117 retinoic acid 1.10837 µM -1.62112616991683 0.0510147287776423 no 3216 0.0524952912591751 4593 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_887 0885-0007 9.62 µM -1.62223226961367 0.0508970265230531 no 3217 0.0523768123309588 4568 5719458 SGTC_931 2812-0076 566 µM -1.62276255841622 0.0508406741651671 no 3218 0.0523200862364611 4488 3450959 SGTC_131 0141-0277 33.849 µM -1.63324725044067 0.0497366620293069 no 3219 0.0512085030061394 4515 1547771 SGTC_1341 1486-1360 280 µM -1.63390040487793 0.049668524347947 no 3220 0.0511398823652703 4564 3976547 SGTC_101 0490-5701 117.494 µM -1.63439127943625 0.0496173648943895 no 3221 0.0510883590834359 4438 4661669 SGTC_814 3342-0569 96 µM -1.6410045461695 0.048932214809087 no 3222 0.0503982357493001 4599 4346283 SGTC_3008 9078912 71.4286 µM -1.65148359721878 0.0478620611080338 no 3223 0.0493199336804355 4578 16648731 SGTC_2889 9059656 51.95 µM -1.65337726713534 0.0476706875141874 no 3224 0.0491270532358506 4610 3949838 SGTC_2179 6298986 200 µM -1.66554615919805 0.0464554830827597 no 3225 0.0479019212722748 4536 738374 SGTC_611 3453-1652 23.7 µM -1.66916366400424 0.0460990675238989 no 3226 0.0475424745294328 4575 1560575 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.68316131485372 0.0447405895915808 no 3227 0.0461719337205638 4611 688788 SGTC_2050 5263056 171 µM -1.68327758423936 0.0447294420884874 no 3228 0.046160683841272 4559 763468 YGL055W OLE1 SGTC_2691 st077356 60.2 µM -1.68450620080804 0.0446117832623918 no 3229 0.0460419410538179 4556 2839272 SGTC_717 1532-0246 73.2 µM -1.68940071324281 0.0441455314383304 no 3230 0.0455713322087515 4584 9561992 SGTC_572 0960-0087 17.7 µM -1.68971162694613 0.0441160469650174 no 3231 0.0455415688864356 4539 6796365 SGTC_1051 3253-3903 78 µM -1.69081148184552 0.0440118732615 no 3232 0.0454364067790247 4574 5509239 SGTC_2812 7970281 58.44 µM -1.6936361247992 0.0437452434906637 no 3233 0.0451672245359962 4596 2233435 SGTC_1301 naphtanilide LB 4.81 µM -1.69620146987544 0.0435042206129761 no 3234 0.0449238661012277 4621 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_659 k018-0002 107 µM -1.69721140869047 0.0434096279814652 no 3235 0.0448283494868488 4562 6797879 YHR007C ERG11 SGTC_2496 diffractaic acid 79.83 µM -1.69918701002591 0.0432250698361203 no 3236 0.0446419765691347 4566 94870 An apoptosis inducer which activates caspases. SGTC_146 3448-8650 53.125 µM -1.70429704506481 0.0427506351413433 no 3237 0.0441628033754371 4557 2891488 YIL048W NEO1 SGTC_592 k241-0073 46.5 µM -1.70972384788419 0.0422514084751265 no 3238 0.0436584753385169 4629 4230158 SGTC_1395 3486-0190 4.35 µM -1.71171535909963 0.0420693911733206 no 3239 0.0434745683672998 4578 6748079 SGTC_1559 coumarin 343 70.1 µM -1.71906894934631 0.0414027895775664 no 3240 0.0428009089523367 4628 108770 A hepatotoxic, DNA x-linker. SGTC_676 falcarinol 140 µM -1.72145131841478 0.0411886732532026 no 3241 0.0425844793906068 4613 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2723 salbutamol 83.58 µM -1.72490829137543 0.0408795739081397 no 3242 0.0422720005534795 4609 9884233 β2-adrenoceptor agonist SGTC_2991 9074669 71.4286 µM -1.72669237807177 0.0407207905493789 no 3243 0.0421114626232495 4543 17333109 SGTC_2368 9071271 200 µM -1.72832044758999 0.0405763297819634 no 3244 0.0419653945555738 4587 27209959 SGTC_984 1492-0255 2.91 µM -1.72928268484126 0.0404911449679035 no 3245 0.0418792570295295 4560 1585198 SGTC_618 k072-0232 33.2 µM -1.73148401086785 0.0402968122170337 no 3246 0.0416827371093134 4626 5872756 YGL099W LSG1 SGTC_743 1275-0778 158 µM -1.73186885599121 0.0402629160595759 no 3247 0.0416484574957597 4580 2849257 YMR203W TOM40 SGTC_1234 0326-0494 15.5 µM -1.74069567654211 0.0394918091502118 no 3248 0.0408684682685655 4649 1547813 SGTC_2893 9048488 25.97 µM -1.74418265833238 0.0391905172502389 no 3249 0.0405636221266144 4638 6467338 SGTC_259 usnic acid 108.925 µM -1.74610026837543 0.0390256255477459 no 3250 0.0403967650967659 4634 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.75586441764044 0.0381947640994023 no 3251 0.0395557809498884 4586 16623 A steroid. SGTC_2135 5326629 150.42 µM -1.75986245159952 0.0378587480630681 no 3252 0.0392155655519157 4570 5020077 SGTC_716 1683-5115 658 µM -1.76578947395137 0.037365052183597 no 3253 0.0387155875520736 4606 723597 SGTC_382 3229-0966 23.2 µM -1.76581374405597 0.0373630414501066 no 3254 0.0387135509574005 4631 5722370 SGTC_3259 9138485 49.47 µM -1.76836408736379 0.0371522423224249 no 3255 0.038500028143499 4576 17646153 SGTC_187 1488-2104 32.728 µM -1.77089776181809 0.0369437843463971 no 3256 0.0382888523114137 4609 2852859 SGTC_3057 9095946 49.47 µM -1.77487836322333 0.0366182125680966 no 3257 0.0379589867986493 4650 24540043 SGTC_964 1287-0107 19.4 µM -1.77745460725173 0.0364087564520018 no 3258 0.0377467365099659 4608 51516812 YPR165W RHO1 SGTC_277 nystatin 15.5 µM -1.78154653910889 0.0360780868445469 no 3259 0.0374116045690968 4635 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.78248744840096 0.0360024006466957 no 3260 0.0373348881308827 4690 688801 SGTC_750 4073-0104 132 µM -1.78273002931337 0.0359829086794304 no 3261 0.037315130301675 4307 22330957 SGTC_271 rotenone 740 µM -1.78817668916883 0.0355475274403168 no 3262 0.0368737529636558 4651 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2447 5741742 33.78 µM -1.79221866608717 0.035227229617495 no 3263 0.0365489728783561 4666 1776504 SGTC_3288 9119690 36.221 µM -1.79392748318958 0.0350925319523507 no 3264 0.0364123720695693 4609 17595618 YKL019W RAM2 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.79445814179249 0.035050788840707 no 3265 0.0363700369728912 4593 5282362 SGTC_322 k048-0136 19.3 µM -1.8009982992388 0.0345396594445561 no 3266 0.03585157401432 4670 6823282 SGTC_2054 5233173 129 µM -1.81015202968831 0.0338345703581736 no 3267 0.0351361071442667 4622 6889 SGTC_634 1611-4317 11.2 µM -1.81127803995526 0.0337486603026362 no 3268 0.0350489116162626 4651 2843522 SGTC_1243 0416-0003 5.65 µM -1.8130766121413 0.0336118088436109 no 3269 0.034910002921754 4609 2141977 SGTC_100 0086-0128 49.5915 µM -1.82271965283013 0.0328858479912677 no 3270 0.0341729310929576 4616 93297 SGTC_3129 9127257 49.47 µM -1.83464763234284 0.0320057999781177 no 3271 0.0332789580965506 4588 837894 SGTC_1202 1988-0068 29.6 µM -1.83509020093352 0.0319735250490476 no 3272 0.0332461628043337 4618 2850480 SGTC_1809 st050081 57.6 µM -1.83723264230268 0.0318176643026073 no 3273 0.0330877793812418 4675 5036894 SGTC_2373 9071805 200 µM -1.83893108272338 0.0316945507142923 no 3274 0.0329626616685862 4640 10149009 SGTC_2714 st079313 56.9 µM -1.84002068166149 0.0316157772223118 no 3275 0.0328826005132011 4635 2939799 SGTC_2916 7875993 68.79 µM -1.8438806959178 0.0313380150353101 no 3276 0.0326002644886169 4557 1299250 SGTC_1933 st074711 15.9 µM -1.84586181645498 0.031196241352753 no 3277 0.0324561360588623 4638 17250958 SGTC_733 4069-0007 56.1 µM -1.84926940182411 0.030953627690607 no 3278 0.032209460854056 4643 5717425 YNL287W SEC21 SGTC_961 1252-1571 372 µM -1.85013730569511 0.0308920846922084 no 3279 0.0321468811346064 4654 6813498 SGTC_32 0928-0142 34.1 µM -1.85111986893786 0.0308225334730372 no 3280 0.0320761551392198 4656 2244242 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.86076894251333 0.0301463817684654 no 3281 0.0313884065706059 4593 2724 A muscle relaxant with antifungal properties. SGTC_893 0958-0369 48.9 µM -1.86582769975361 0.0297968351226867 no 3282 0.0310327377875161 4512 6819948 SGTC_411 enrofloxacin 100 µM -1.88046576733354 0.0288042793263724 no 3283 0.0300223138072413 4679 71188 A bacterial gyrase inhibitor. SGTC_2294 7971431 200 µM -1.90020732195301 0.0275093502936185 no 3284 0.0287029588961884 4641 5741572 SGTC_763 3453-1109 128 µM -1.9002820315957 0.0275045435298925 no 3285 0.0286980590406588 4679 1560353 SGTC_315 k915-0449 187 µM -1.90091425665038 0.0274638946618552 no 3286 0.0286566222028423 4679 20970215 YNL149C PGA2 SGTC_1354 1498-1681 81 µM -1.90386467329591 0.0272748595692581 no 3287 0.0284639054992202 4685 5754243 SGTC_2940 9060638 45.86 µM -1.90423057437451 0.0272514918769855 no 3288 0.0284400807285395 4621 4027022 SGTC_2339 9000433 200 µM -1.90751161753177 0.0270426986305151 no 3289 0.0282271840401715 4616 2988954 SGTC_1769 st044406 64.4 µM -1.92549106161717 0.0259221213804412 no 3290 0.0270839765649829 4653 670903 SGTC_1178 0988-0033 191 µM -1.9272373199514 0.0258153853757068 no 3291 0.026975030494163 4697 5392207 SGTC_2304 7443016 91.4 µM -1.92742885691669 0.0258037005357931 no 3292 0.0269631031227897 4629 939854 SGTC_420 mitomycin C 81.9 mM -1.92914543003174 0.0256991773039944 no 3293 0.0268564052358768 4648 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2105 5350118 200 µM -1.93385070799403 0.0254144856378017 no 3294 0.0265657430502084 4644 2133313 SGTC_734 2023-0417 80 µM -1.93617360822629 0.0252749159820974 no 3295 0.0264232208409775 4663 3935732 SGTC_2699 st077704 54.6 µM -1.9569181656171 0.0240567410413508 no 3296 0.0251785452239792 4664 645852 SGTC_323 4013-0906 34.3 µM -1.96799257061779 0.0234268745583113 no 3297 0.0245344462698823 4698 2910086 SGTC_379 3970-0972 5.9 µM -1.98922454087571 0.0222580553290574 no 3298 0.0233382121556539 4683 2898042 YBL034C STU1 SGTC_947 3447-0010 211 µM -2.00599370008146 0.0213700437143519 no 3299 0.0224284600762115 4640 748350 SGTC_802 4112-3352 742 µM -2.01709527454037 0.0207987902613397 no 3300 0.0218427858434304 4705 704594 SGTC_3130 9127414 49.47 µM -2.02873143591996 0.0202139599883061 no 3301 0.0212428260879328 4708 1494646 SGTC_1308 1187-1617 41.4 µM -2.03808925662996 0.0197538096439521 no 3302 0.0207705036901489 4714 2882570 SGTC_2938 9059746 27.26 µM -2.03973914311725 0.0196736091270686 no 3303 0.0206881570186696 4656 6471769 SGTC_79 0052-0007 94.094 µM -2.0450039596345 0.0194195340515763 no 3304 0.0204272338667463 4681 2801472 SGTC_2380 9035439 200 µM -2.04924445489827 0.0192169236741811 no 3305 0.0202191085367461 4720 6462575 SGTC_2874 9043904 71.43 µM -2.06966613780472 0.0182661621097415 no 3306 0.0192418099379768 4641 4463428 SGTC_566 0958-0068 16.5 µM -2.07114236984956 0.0181990150034074 no 3307 0.0191727466650849 4635 6815365 SGTC_2883 9059145 45.46 µM -2.08963028617341 0.0173757414621347 no 3308 0.0183255118808763 4702 16476510 SGTC_1466 k213-0079 57.5 µM -2.10437941593256 0.0167419655486127 no 3309 0.0176726817567472 4720 3657981 SGTC_577 r071-0003 38.6 µM -2.10603329446684 0.0166721464808169 no 3310 0.0176007301766401 4682 4568517 YMR134W ERG29 SGTC_1899 st063254 59.6 µM -2.12324657329626 0.0159601515010859 no 3311 0.0168665975582905 4705 3093813 SGTC_2564 betulinic acid 100 µM -2.14030933430747 0.0152802683569009 no 3312 0.0161648880659052 4667 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2635 hydroquinidine 100 µM -2.14299726635515 0.0151754655551759 no 3313 0.0160566589375584 4667 442912 An experimental heart treatment. SGTC_1756 st041558 35.5 µM -2.16173813658566 0.0144617778446152 no 3314 0.0153191831500692 4753 3955792 SGTC_917 harmaline 728.087 nM -2.17104829333757 0.0141181024634977 no 3315 0.0149637610023445 4660 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1521 st012942 49.4 µM -2.17117304552281 0.0141135455582932 no 3316 0.0149590470346509 4642 24207259 SGTC_2974 9094440 9.66 µM -2.18215077153687 0.0137174864002006 no 3317 0.0145492035695205 4680 25236134 SGTC_2591 skatole 100 µM -2.18328679377892 0.0136770532958971 no 3318 0.0145073482371329 4683 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_575 k072-0246 11.9 µM -2.203221166262 0.0129841069428738 no 3319 0.0137895820830745 4772 6796779 SGTC_2587 piperic acid 92.2 µM -2.21071062609862 0.0127317208202967 no 3320 0.0135279411090798 4681 5370536 SGTC_2495 cafestol 54.53 µM -2.24200103433193 0.0117226474910904 no 3321 0.0124806527283586 4712 16667697 An anti-infammatory. SGTC_1972 st070201 17.4 µM -2.27399227534255 0.0107634706666365 no 3322 0.0114832254864885 4738 2829099 SGTC_3313 9133968 57.047 µM -2.30147946030155 0.00999465641691671 no 3323 0.0106822725309634 4740 1494643 SGTC_1539 benzyladenosine 56 µM -2.30292148490738 0.00995568095861139 no 3324 0.0106416305432346 4769 92208 A nucleotide analog. SGTC_1588 farnesol 29.9 µM -2.32764278131019 0.00930784554779823 no 3325 0.00996553988691854 4751 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2344 7990960 76.95 µM -2.33047844973154 0.00923594677473759 no 3326 0.00989043885968329 4712 140813 SGTC_2656 pseudo-anisatin 100 µM -2.35537619572747 0.00862525163849042 no 3327 0.00925198095101014 4782 6708809 A neurotoxin. SGTC_324 1315-0088 19.6 µM -2.3679729816864 0.00832999080121762 no 3328 0.00894292099903628 4758 6787421 SGTC_2365 9042475 200 µM -2.37082252991371 0.00826444330852839 no 3329 0.00887427547644786 4737 6464479 SGTC_380 3970-0968 6 µM -2.39522269943864 0.00772147106467726 no 3330 0.00830513658874159 4724 2891601 SGTC_52 0329-0193 875 nM -2.41229695236616 0.00736043562015057 no 3331 0.00792618222502523 4743 3739292 SGTC_1300 1094-0077 113 µM -2.41626858581383 0.00727861958709247 no 3332 0.00784024503054262 4762 5532636 SGTC_1964 st076914 61 µM -2.42101913041623 0.00718181187075701 no 3333 0.00773853138031467 4774 24208661 SGTC_2930 9013230 14.89 µM -2.55048792344437 0.00494545330688172 no 3334 0.0053786125432234 4737 2995857 SGTC_1555 citronellol 128 µM -2.57221912158582 0.0046380685513549 no 3335 0.00505244566355468 4771 8842 A terpine precursor. SGTC_1965 Pectolinarigenin 58.4 µM -2.58956290808315 0.00440509924402154 no 3336 0.00480489313489645 4764 5320438 An anti-inflammatory. SGTC_693 4161-2696 114 µM -2.6218615760242 0.00399895096738947 no 3337 0.00437254712118518 4780 805759 SGTC_1765 st044815 90.4 µM -2.65495149787465 0.00361794669226445 no 3338 0.00396599062024957 4774 645695 SGTC_2112 5488546 200 µM -2.66586116933728 0.00349966724310655 no 3339 0.00383956986864783 4753 600757 SGTC_1195 1502-0147 41.1 µM -2.81314284148934 0.00220971400086155 no 3340 0.00245299263006948 4793 817940 SGTC_1944 st076371 56.9 µM -2.82264269058195 0.00214361864069424 no 3341 0.00238148108279617 4773 24208455 SGTC_2948 9070189 9.45 µM -2.82620592388214 0.00211929333163279 no 3342 0.00235514862101309 4737 6473636 YDL196W YDL196W SGTC_696 1560-0013 611 µM -2.82891405907853 0.00210097331222429 no 3343 0.00233531196759187 4785 1650269 SGTC_1880 MG-132 525 µM -2.83216442976794 0.00207917491950999 no 3344 0.00231170332932123 4764 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1298 1079-1278 263 µM -2.8813305811797 0.00177354098623415 no 3345 0.00198000030403364 4782 2840950 SGTC_2596 sinensetin 100 µM -2.88672691479823 0.00174261463286112 no 3346 0.00194635967686677 4755 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3322 9139058 2.11 µM -2.91161432976229 0.00160623916335887 no 3347 0.00179783146090273 4791 4908926 YPR165W RHO1 SGTC_2333 9017922 200 µM -2.9733094864754 0.00130907526619693 no 3348 0.00147303616262279 4769 3163164 SGTC_3326 9140064 16.379 µM -3.07589564237415 0.000924095780748293 yes 3349 0.0010493564278461 4782 1868434 SGTC_2622 2-methoxyxanthone 59.94 µM -3.17550133559201 0.000652604099040973 yes 3350 0.000747889165212432 4795 71034 A hepatoprotective. SGTC_2595 hexamethylquercetagetin 100 µM -3.19380454897642 0.000611557927318229 yes 3351 0.000702055731970383 4778 386331 SGTC_2756 carbadox 75.1 µM -3.4359242880734 0.000251170920395536 yes 3352 0.00029526798918693 4776 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2750 bromebric acid 70.15 µM -3.51336739555871 0.000186694421697307 yes 3353 0.000221232603449279 4795 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2317 5986382 200 µM -3.78127748948458 6.39433722390447e-05 yes 3354 7.80128208681331e-05 4802 877883 SGTC_2481 5478948 45.16 µM -4.33552001799885 5.56984200742042e-06 yes 3355 7.27079697800044e-06 4805 77792 SGTC_2971 9092186 9.93 µM -5.53551274472034 9.9221568340049e-09 yes 3356 1.55159583468737e-08 4809 25236400