SGTCid condition conc unit YEA4|YEL004W.score YEA4|YEL004W.strain.pval YEA4|YEL004W.strain.significant YEA4|YEL004W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_284 0988-0104 32.6 µM 4.8429049318943 1.67617793197216e-08 yes 1 6.39772592342304e-07 6 4666532
SGTC_2288 7946289 167.31 µM 4.5013670778749 1.40725455057393e-07 yes 2 3.37588918716484e-06 16 1246052
SGTC_67 0335-0847 266 µM 3.64719969145705 1.53070533089245e-05 yes 3 0.000132556942262334 136 4552207 YOR254C SEC63
SGTC_3202 9113761 49.47 µM 3.63771717985873 1.6043967098721e-05 yes 4 0.000137532613065553 59 4798415
SGTC_2605 digitonin 300 nM 3.37046669192998 5.77026892140361e-05 yes 5 0.00037520488581413 54 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1284 0929-0043 16 µM 3.05571857751236 0.000233062607845232 yes 6 0.00112260942422667 66 1239883
SGTC_1270 0831-1170 17.3 µM 3.03426430039559 0.000255212462077897 yes 7 0.00120561543090733 46 6764716
SGTC_1276 0871-0068 94.2 µM 2.99791901040252 0.000297267737252024 yes 8 0.00135914950368402 51 3414906
SGTC_1231 0242-0792 125 µM 2.98006024160393 0.000320217562486504 yes 9 0.00144095850859188 64 3707635
SGTC_2935 9038016 29.96 µM 2.90741485781396 0.000431622396978776 yes 10 0.00182214767650248 67 6463195
SGTC_279 1273-0055 2.93 µM 2.90393672491518 0.000437766605932288 yes 11 0.00184251313432427 93 2847562
SGTC_763 3453-1109 128 µM 2.85798561116826 0.000526926899092242 yes 12 0.00213169861839136 66 1560353
SGTC_1343 1487-0095 224 µM 2.71816078303938 0.000911933346629774 yes 13 0.00328229648714175 53 4560101 YGL055W OLE1
SGTC_1521 st012942 49.4 µM 2.71700756894533 0.000915979010552588 yes 14 0.00329375505954283 117 24207259
SGTC_1332 1480-0653 17.5 µM 2.71420720655763 0.000925871883412307 yes 15 0.00332172991030336 86 5749438
SGTC_1600 coumarin 106 71.1 µM 2.71217504311333 0.000933112292449357 yes 16 0.00334216422870725 94 100336 A hepatotoxic, DNA x-linker.
SGTC_2970 9090938 41.86 µM 2.64375972423182 0.00120942268094498 no 17 0.00409954177609065 155 17217104
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.62537742806629 0.00129548092412422 no 18 0.0043276482781028 138 688788
SGTC_249 wiskostatin 11.211 µM 2.60251539840664 0.00141031212416834 no 19 0.00462713296256619 77 2775510 A n-wasp and actin depolymerizer.
SGTC_2932 9016711 44.54 µM 2.59332942963019 0.00145901332641934 no 20 0.00475258377030857 153 7117328
SGTC_2107 5363541 170.161 µM 2.57500559156435 0.00156077366726232 no 21 0.00501192330689147 82 244052
SGTC_1338 1486-1223 76 µM 2.55624228112097 0.00167164200378524 no 22 0.00529047089907997 102 3444526
SGTC_822 1487-0950 154 µM 2.50696504481724 0.00199779167881558 no 23 0.0060886376717978 96 1958375
SGTC_283 0987-0079 11.7 µM 2.49260291982391 0.00210317563834755 no 24 0.00634052866086554 137 411556
SGTC_389 tpck 16.7 µM 2.48123833513956 0.00219011100411337 no 25 0.00654633990463494 119 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2967 9089538 49.85 µM 2.47509430063343 0.00223845550710117 no 26 0.00666005001235114 143 728216
SGTC_634 1611-4317 11.2 µM 2.45772001566321 0.00238044365736672 no 27 0.0069911067526575 119 2843522
SGTC_2620 irigenin 100 µM 2.42340441042426 0.00268507088985793 no 28 0.00768789959788104 154 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_280 3448-3607 3.04 µM 2.41298773309804 0.00278427098969856 no 29 0.00791117603958046 82 626179
SGTC_2335 9018011 154.17 µM 2.36730213601699 0.00325954235934483 no 30 0.00895914914042195 155 6458208
SGTC_1106 tegaserod maleate 11.7 µM 2.33619672688408 0.00362365564418372 no 31 0.00974049541110845 163 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_813 k007-0158 173 µM 2.33438018869728 0.00364600654867392 no 32 0.00978791160730294 184 6523916
SGTC_2103 5378138 10 µM 2.30833395913145 0.0039803675678629 no 33 0.0104902845216984 143 244142
SGTC_766 1391-0721 126 µM 2.30055983287039 0.00408535374757887 no 34 0.0107082618210403 138 1020919 YIL115C NUP159
SGTC_53 0973-0023 39.979 µM 2.28452123767273 0.00430981286185659 no 35 0.0111704579502202 135 674768
SGTC_1271 0832-2808 169 µM 2.25308651168162 0.00478195280700823 no 36 0.0121268473832495 154 3663794
SGTC_884 0851-0618 334 µM 2.23228620396662 0.00511920412171981 no 37 0.0127980265507126 168 9642473
SGTC_621 3584-0052 32.1 µM 2.23210390504635 0.00512225117904382 no 38 0.0128040482039784 170 2273927
SGTC_2015 5119600 184 µM 2.23025807548189 0.00515319456955437 no 39 0.0128651573662171 171 2828786
SGTC_2933 9026794 32.47 µM 2.22643318669879 0.00521784487648531 no 40 0.0129925898171747 189 17586027
SGTC_1169 aniline yellow 25.8 µM 2.20853808688321 0.00553000166341662 no 41 0.0136033929240151 125 6051 A DNA damaging agent.
SGTC_2829 7992743 58.44 µM 2.19615137642676 0.0057556807666435 no 42 0.0140405551541936 215 16462845
SGTC_2097 5376186 200 µM 2.18464536701179 0.00597259798159848 no 43 0.0144574294128821 185 742755
SGTC_2986 9022445 71.43 µM 2.17877519528891 0.00608603328592023 no 44 0.0146741862494498 175 6459286
SGTC_973 1325-0077 65.9 µM 2.17851394626791 0.00609112574712059 no 45 0.0146838975425985 175 2835149
SGTC_1567 st069303 68.4 µM 2.16202762422879 0.00642022552059468 no 46 0.0153080234922184 191 5581319
SGTC_1191 1487-1166 10.6 µM 2.16112387272331 0.00643871273631276 no 47 0.0153428859719951 204 3955771
SGTC_995 3931-2021 34.6 µM 2.12326027002657 0.00725681389798313 no 48 0.0168660239932495 181 730143
SGTC_734 2023-0417 80 µM 2.12245355767863 0.00727519882220896 no 49 0.0168998343775148 187 3935732
SGTC_2583 asiatic acid 100 µM 2.11560834620054 0.00743286061680205 no 50 0.0171890657098973 196 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_57 miconazole 162.5 nM 2.10740207071363 0.00762583297775099 no 51 0.0175413711377662 179 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1654 st012436 41.8 µM 2.10708624947836 0.00763334693182965 no 52 0.0175550520124398 148 4323132
SGTC_1176 0848-0131 83.3 µM 2.0771028368588 0.00837706547014226 no 53 0.0188960344083082 227 6769040
SGTC_2076 5212012 200 µM 2.0414904322949 0.00934244222480798 no 54 0.0206010519580097 115 604802
SGTC_807 1315-0151 48 µM 2.03798407604855 0.00944255999990361 no 55 0.0207757627035218 241 4011080
SGTC_1183 1254-0324 198 µM 2.02683623578052 0.00976712686122755 no 56 0.0213395816690746 190 5799357
SGTC_2608 thymoquinone 42.66 µM 2.00011340258281 0.0105851128918198 no 57 0.0227440099274207 187 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3096 9117468 49.47 µM 1.99385611726635 0.010785056515546 no 58 0.0230838903951028 130 41316311
SGTC_1780 st038448 24.544 µM 1.97748198348005 0.0113239035363128 no 59 0.0239935875194828 234 728868 YDL195W SEC31
SGTC_2804 7954240 19.48 µM 1.95402368138454 0.0121365859962121 no 60 0.0253492083179449 259 828705
SGTC_1861 st057647 17.4 µM 1.95196983375081 0.012210088349979 no 61 0.0254708931065622 232 688668
SGTC_1420 4'-methoxyflavone 42 µM 1.94725985326575 0.0123801056216136 no 62 0.0257517946083742 200 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1758 st042942 75.2445 µM 1.94626499114834 0.0124162785511275 no 63 0.0258114583068471 213 669317
SGTC_431 k089-0097 107 µM 1.94535920438235 0.0124492922982374 no 64 0.0258658805593101 318 5499420
SGTC_3034 9090421 49.47 µM 1.93913476548184 0.0126782208374815 no 65 0.0262424652062206 185 17173761
SGTC_1673 st016611 27.3 µM 1.93051905166538 0.0130011041267492 no 66 0.0267712784706515 290 5226799
SGTC_1117 retinoic acid 1.10837 µM 1.92225779190622 0.0133173558233629 no 67 0.0272866640757248 248 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3033 9090887 49.47 µM 1.88599475013504 0.0147853657395205 no 68 0.0296478310565022 282 19325384
SGTC_2595 hexamethylquercetagetin 100 µM 1.87843861770139 0.0151081919222632 no 69 0.0301605933891655 240 386331
SGTC_376 3970-0862 59.1 µM 1.85550882982073 0.0161251704350035 no 70 0.0317617997498083 262 3135186
SGTC_365 0121-0052 13.6 µM 1.83832037539391 0.016925472961155 no 71 0.033007605209691 377 3101739
SGTC_806 3966-4455 5.86 µM 1.83247666033583 0.0172051856713387 no 72 0.0334402179618785 241 714982
SGTC_803 4488-1585 147 µM 1.81749677596559 0.0179403040211408 no 73 0.0345705407615989 242 747204
SGTC_1105 epirubicin 18.1 µM 1.80523183505262 0.0185619758296394 no 74 0.0355192056157549 269 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_798 1287-0182 476 µM 1.78039945054678 0.0198769535608504 no 75 0.0375053058170554 336 1649755
SGTC_3162 9099653 49.47 µM 1.76586921877355 0.0206824420392501 no 76 0.0387088961954254 231 25237511
SGTC_604 1000-0114 314 µM 1.75949794396792 0.0210442594016279 no 77 0.0392464845793071 312 1572745
SGTC_3039 9090270 49.47 µM 1.75775615394442 0.0211441009060892 no 78 0.0393945043418029 243 17173750
SGTC_1306 1185-0270 9.02 µM 1.74727927779344 0.0217531391074723 no 79 0.0402944528998774 322 1548076
SGTC_1501 4491-0275 38.4 µM 1.74507102173944 0.021883382254599 no 80 0.0404862535253423 270 5104718
SGTC_1556 plumbagin 1.48 µM 1.73003727901936 0.0227876889045253 no 81 0.0418118074883807 248 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1101 ebselen 5.29 µM 1.72416075554171 0.0231496334491312 no 82 0.0423394132983897 319 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1764 st044502 93.5 µM 1.7224982800837 0.0232529020686469 no 83 0.0424896470447834 330 8407
SGTC_1997 st073024 93.8 µM 1.71668809161809 0.023616866491198 no 84 0.0430180885638052 288 686268
SGTC_326 k292-0812 17.5 µM 1.71229267250599 0.0238953792524989 no 85 0.0434213731813355 258 3579357
SGTC_1757 st041620 31.8375 µM 1.70977566893476 0.0240561069018273 no 86 0.0436536819585277 328 5289815
SGTC_1291 0993-0025 5.79 µM 1.70412563200966 0.024420210019487 no 87 0.0441788094689925 305 4353356
SGTC_1315 1237-0019 3.69 µM 1.70140641007463 0.0245970861789968 no 88 0.0444333492300522 296 825140
SGTC_1116 jasmonic acid 1.58368 µM 1.69611098810713 0.0249446214571954 no 89 0.0449324315529092 329 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1727 st034309 9.9045 µM 1.68290061795828 0.0258295941830595 no 90 0.0461971659788682 421 870305
SGTC_1644 st010134 20.9 µM 1.67963107677696 0.0260526342545332 no 91 0.0465145586756031 286 3818134
SGTC_1972 st070201 17.4 µM 1.67924628787955 0.026078989241387 no 92 0.046552027123885 326 2829099
SGTC_1263 0774-1208 64.8 µM 1.67455114382876 0.0264023691777144 no 93 0.0470111659200143 410 906585
SGTC_3064 1327-0027 10 µM 1.67276928870865 0.0265259692790688 no 94 0.0471863614646804 178 16000455 YPR107C YTH1
SGTC_1021 4476-0760 85.3 µM 1.6710781746209 0.0266437218216864 no 95 0.0473531188565268 354 746768
SGTC_3127 9126946 49.47 µM 1.65027829935734 0.0281280707285064 no 96 0.0494430143046207 313 27243249
SGTC_665 3914-0008 307 µM 1.6442179575084 0.0285732918420604 no 97 0.050065594456917 354 1069549
SGTC_745 0469-0705 296 µM 1.62957627347864 0.0296731702783281 no 98 0.0515955411840194 400 3486736
SGTC_2700 st077718 96.8 µM 1.62268794723468 0.0302026447719163 no 99 0.0523280645992548 314 904970
SGTC_2108 5365811 200 µM 1.61061197619746 0.0311497607706502 no 100 0.0536321609313794 372 780283
SGTC_1570 verbenone 133 µM 1.60135101478666 0.0318926292537874 no 101 0.0546495979064311 353 29025 A natural terpanoid with antifungal properties.
SGTC_7 0192-1582 4.227 µM 1.59978695197398 0.0320195235232473 no 102 0.0548229271924191 462 252616
SGTC_3 0833-0587 95.581 µM 1.59384272238777 0.032505594610307 no 103 0.0554856329896143 334 5382644
SGTC_861 0443-0273 110 µM 1.59356723956468 0.0325282681524257 no 104 0.0555164984868881 344 6149169
SGTC_1031 k035-0009 16 µM 1.59239557918922 0.0326248471354954 no 105 0.0556479244684848 407 5180959
SGTC_2908 7930301 100 µM 1.58890718639471 0.0329137934843071 no 106 0.0560406742511037 410 2223178
SGTC_2004 4023728 41.89 µM 1.58849478179339 0.0329480922788666 no 107 0.0560872500457815 411 360084 YDR527W RBA50
SGTC_769 0302-0231 76 µM 1.58602908792578 0.0331537737351941 no 108 0.0563663556336874 471 571869 YER009W NTF2
SGTC_3320 9137005 35.139 µM 1.57165467353469 0.034374005074954 no 109 0.0580153297118974 358 4908713
SGTC_227 fluconazole 33.516 µM 1.56805600977865 0.0346852015908422 no 110 0.0584340307853538 463 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_394 menadione 8.33 µM 1.56249399681832 0.0351707282894197 no 111 0.0590858294925223 402 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1726 st035556 14.5795 µM 1.5576495837236 0.0355981437128562 no 112 0.0596581689395143 422 5919439
SGTC_1115 galangin 695.678 nM 1.55685457326584 0.0356686913598036 no 113 0.0597525084185197 421 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1079 idarubicin 2.36 µM 1.55383505933006 0.0359376818565335 no 114 0.060111882697814 353 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2150 5556613 200 µM 1.55269813339056 0.0360393934811477 no 115 0.0602476342425552 420 743190
SGTC_2346 9031566 143.75 µM 1.55037601426917 0.0362478673705993 no 116 0.0605256460538285 364 4771086
SGTC_418 lividomycin a 100 µM 1.54981779877403 0.036298129437668 no 117 0.0605926268768624 383 72394 An antibiotic.
SGTC_2121 5257820 149.641 µM 1.54404362594347 0.0368213940384088 no 118 0.0612888821604603 418 791256
SGTC_2602 kawain 100 µM 1.54224896254357 0.0369852801671442 no 119 0.0615065530349314 450 5369129
SGTC_2983 9022671 12.99 µM 1.54075458221982 0.0371221994092733 no 120 0.0616882635126101 372 6405161
SGTC_622 1348-1566 26.3 µM 1.53574821601414 0.0375839177628551 no 121 0.0623000723232495 429 7340407
SGTC_564 3555-0129 330 µM 1.53568087513062 0.0375901601741395 no 122 0.0623083339327071 304 563260
SGTC_1968 st069590 43.6 µM 1.53061046145895 0.0380626178783136 no 123 0.0629328473278347 390 6384066
SGTC_385 1494-0393 12.4 µM 1.5207192604338 0.0389982129853962 no 124 0.0641651516157501 413 3090647
SGTC_1434 4073-0095 163 µM 1.52040193691335 0.0390285354394933 no 125 0.064204993990091 413 24133745
SGTC_2840 9008771 71.43 µM 1.50826993622251 0.0402023025382969 no 126 0.0657427271839577 350 2992978
SGTC_1435 4092-0789 56.7 µM 1.50809026728834 0.0402198985826067 no 127 0.0657657129179348 399 2248285
SGTC_164 4100-3994 89.624 µM 1.50589523712584 0.0404353763945109 no 128 0.06604703471833 476 4615967
SGTC_1203 3992-3522 103 µM 1.50264526709532 0.0407561340352684 no 129 0.0664652718535362 453 5322312
SGTC_2393 9031399 185.94 µM 1.49945036626886 0.0410734660180543 no 130 0.0668784178578727 427 1526623 YDL150W RPC53
SGTC_155 k072-0202 43.6 µM 1.49942193331817 0.0410762990765935 no 131 0.0668821035406401 375 5857737
SGTC_2918 7977171 22.06 µM 1.49743818721113 0.0412743510382234 no 132 0.0671396390620078 396 2236483
SGTC_266 formosanin C 406 nM 1.49513373351153 0.0415053927648401 no 133 0.0674397717961643 448 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1742 st038235 28.8875 µM 1.49398623653429 0.0416208296274306 no 134 0.0675896083513291 475 564103 YBR002C RER2
SGTC_882 0843-0131 351 µM 1.49322936410498 0.0416971123649164 no 135 0.0676885790747555 443 5425421
SGTC_1346 1488-2224 62.4 µM 1.4905236990057 0.0419707340926452 no 136 0.0680432949390591 427 3722427
SGTC_545 4218-0007 221 µM 1.4882954566607 0.0421971643214881 no 137 0.0683364963086393 401 2840508
SGTC_39 0986-0283 58.349 µM 1.48241972680806 0.0427989886738283 no 138 0.0691143241187488 498 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1351 1496-0003 46.5 µM 1.47835102510039 0.0432197783861628 no 139 0.069656923410432 437 3891978
SGTC_2753 fluvastatin 17.09 µM 1.47464183618058 0.0436062923184247 no 140 0.0701544304966307 467 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_846 0335-0850 148 µM 1.47131828633705 0.0439549860513138 no 141 0.0706025301263117 389 6819598
SGTC_899 1083-0020 478 µM 1.45902517543721 0.0452643156465286 no 142 0.0722790893344736 458 767123
SGTC_3095 9117207 49.47 µM 1.4550965821443 0.0456893018837475 no 143 0.072821262631631 360 17015229
SGTC_1216 1165-0504 9.65 µM 1.45313112849686 0.0459031207342572 no 144 0.073093674857565 458 6304004
SGTC_2249 haloperidol 116.36 µM 1.45271855632563 0.045948105805566 no 145 0.0731509563356482 593 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_378 3970-0959 8.33 µM 1.45041764177978 0.0461996374912306 no 146 0.0734710452099485 444 6615653
SGTC_127 0180-0333 59.125 µM 1.44890101452831 0.0463660361600365 no 147 0.0736826139004227 548 771601
SGTC_650 1328-0195 38 µM 1.44456805805582 0.0468440840739282 no 148 0.0742896251285976 472 2780821
SGTC_2130 NSC 7 2.4545 µM 1.44179046045778 0.047152605727529 no 149 0.0746807474241354 485 21448
SGTC_2096 5468907 200 µM 1.43961527556403 0.0473953499300647 no 150 0.0749881377163889 435 759785
SGTC_1825 st052143 62.6 µM 1.43432239281056 0.0479902036773017 no 151 0.0757401414696351 397 674173
SGTC_1721 st082152 9.2685 µM 1.43032504492766 0.0484434042954086 no 152 0.0763118749503602 423 5296051
SGTC_2396 5342950 42.78 µM 1.42877528851287 0.0486200265099097 no 153 0.0765344151543702 512 1886677
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.42741329943932 0.048775673998203 no 154 0.076730399807384 470 5282309
SGTC_3027 9089541 49.47 µM 1.42568052434216 0.0489742700744951 no 155 0.0769802903656486 477 9943819
SGTC_3061 glucosamine 200 µM 1.41953746116019 0.0496835459797888 no 156 0.0778711917038501 430 91431 and experimental redox chemotherapeutic
SGTC_1162 k048-0130 20.1 µM 1.41147858009064 0.0506264233732309 no 157 0.0790517735728893 465 6797406
SGTC_746 1095-0025 46.6 µM 1.41019465102704 0.050777948918738 no 158 0.0792411074104516 496 6749286
SGTC_1987 st072290 61.9 µM 1.4079313787443 0.0510459328488369 no 159 0.079575695216639 482 54697379
SGTC_1793 st048256 72.231 µM 1.40546155693206 0.0513396565107097 no 160 0.0799420365580148 438 672022
SGTC_862 0452-0056 10.2 µM 1.4019610496114 0.0517582557471409 no 161 0.0804634391311389 458 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1167 k781-0610 148 µM 1.39835114939007 0.0521927732009575 no 162 0.0810038225098476 519 4525169
SGTC_964 1287-0107 19.4 µM 1.39618433062943 0.0524549776952204 no 163 0.0813294970196597 527 51516812 YPR165W RHO1
SGTC_2807 7945238 51.95 µM 1.39512899070506 0.0525830614108399 no 164 0.0814884726545436 499 17148797
SGTC_2524 avocatin b 10.57 µM 1.39454521994243 0.0526540186237063 no 165 0.0815765120668252 437 6710748
SGTC_112 phenothiazine 287.218 µM 1.39140951525777 0.0530364640002588 no 166 0.0820506404266473 490 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_607 4491-0986 66.8 µM 1.38904840053428 0.0533258879278596 no 167 0.0824090163614804 515 698981 YDR232W HEM1
SGTC_2407 paclitaxel 400 µM 1.38650607337764 0.0536389228793721 no 168 0.0827962135252511 519 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_938 3126-1755 342 µM 1.38536853677298 0.0537794574938688 no 169 0.0829699032888264 505 1777771
SGTC_2504 purpurogallin 52.29 µM 1.37928778509909 0.0545356432390878 no 170 0.0839030205694897 462 5281571 An antioxidant.
SGTC_2617 dihydrotanshinone i 20.83 µM 1.37886791978346 0.0545881653415987 no 171 0.0839677403961629 533 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1219 1469-0211 33.1 µM 1.37805881691923 0.0546894910384023 no 172 0.0840925646677922 463 6822282
SGTC_2325 6158266 200 µM 1.37598143256119 0.0549503274324582 no 173 0.0844136908950443 496 3623240
SGTC_1620 st003704 16.5 µM 1.36371416111231 0.0565107042030677 no 174 0.0863287726764785 488 2834414
SGTC_593 1203-0218 61.7 µM 1.36286367402728 0.0566201660399759 no 175 0.0864627395266885 517 3666956
SGTC_1371 2421-0008 32.7 µM 1.36113816898535 0.0568427601747676 no 176 0.0867350147437891 520 2827552
SGTC_219 mitoxanthrone 164.414 µM 1.35859616899246 0.0571719388817974 no 177 0.0871372949136217 512 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1260 0700-1617 7.75 µM 1.3553667736399 0.0575922942448423 no 178 0.0876503651131599 556 2853078
SGTC_2588 indole-3-carbinol 100 µM 1.35492146617702 0.057650448059767 no 179 0.0877212898061648 556 3712 Induces cell cycle arrest.
SGTC_3065 9113888 49.47 µM 1.35421446197917 0.0577428723539873 no 180 0.0878339832113709 457 16648368
SGTC_808 0711-0032 135 µM 1.35016514677274 0.0582744722030827 no 181 0.0884815076009818 488 4252555
SGTC_1739 st037196 92.5 µM 1.34448985327614 0.0590259937025315 no 182 0.0893950176928748 542 612214
SGTC_2707 st078556 66.6 µM 1.34113102038667 0.0594743384331186 no 183 0.0899389586726927 498 17250899
SGTC_2960 9079389 5.97 µM 1.33215583155634 0.060685467619628 no 184 0.0914044935160531 537 16457355
SGTC_3090 9117696 49.47 µM 1.32960704195666 0.0610328999287146 no 185 0.091823888364345 485 7923821
SGTC_116 0155-0182 31.788 µM 1.32864096860821 0.061164993588327 no 186 0.0919832244865905 658 771486
SGTC_737 1950-0117 57.9 µM 1.32257263902765 0.0619998474567232 no 187 0.0929887691054417 514 5393513
SGTC_1421 4029-0249 71.4 µM 1.32248253686847 0.062012309971729 no 188 0.0930037603447615 563 2894095
SGTC_2763 lisinopril 49.32 µM 1.32137669082782 0.0621654247606619 no 189 0.0931878970640936 484 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_670 4204-0025 119 µM 1.32036074656979 0.0623063515842796 no 190 0.093357301365736 557 719039
SGTC_2518 prenyletin 46.28 µM 1.31864339803765 0.0625451402017957 no 191 0.0936441789324045 426 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1174 0739-0097 51.1 µM 1.31813117633674 0.0626164999923405 no 192 0.0937298698204642 558 728447
SGTC_2863 9028737 58.44 µM 1.31389905132887 0.063208526079459 no 193 0.0944400890063478 468 6460917
SGTC_2064 5220758 200 µM 1.31080043805774 0.0636447437873666 no 194 0.0949625972641074 590 788518
SGTC_2176 5809774 33.9695 µM 1.30962482788836 0.063810855851653 no 195 0.0951613925380771 557 2870539
SGTC_600 1495-0418 41.6 µM 1.30649055585405 0.064255372222919 no 196 0.0956928943013601 505 5377768
SGTC_3084 9116877 49.47 µM 1.30524009140943 0.0644333888247604 no 197 0.0959055532511996 447 27241325
SGTC_987 1497-1013 404 µM 1.30364725881075 0.0646606997348003 no 198 0.0961769397796736 502 1676435
SGTC_217 ketoconazole 989 nM 1.29957465322391 0.0652447276254216 no 199 0.0968733958178682 532 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2083 5306046 65.942 µM 1.2975775186671 0.0655326162621712 no 200 0.0972162757610352 564 539837
SGTC_2311 7694451 200 µM 1.29676762157653 0.0656496439645767 no 201 0.0973555772177365 557 2163142
SGTC_1652 st011932 78 µM 1.29484443260286 0.065928188175567 no 202 0.097686950324903 524 1551076
SGTC_1158 4092-0494 91.8 µM 1.29225051360994 0.0663053268246006 no 203 0.0981352017352005 580 1148199
SGTC_3262 9137218 49.47 µM 1.29206203840365 0.06633279484591 no 204 0.0981678304921193 378 17650664
SGTC_542 3381-0244 89.3 µM 1.29156845703903 0.0664047702175295 no 205 0.0982533167703318 622 1112843
SGTC_3012 9080433 71.4286 µM 1.28833560076178 0.0668776900887819 no 206 0.0988145827775609 572 17688859
SGTC_1881 5652484 16 µM 1.28703701211786 0.0670683866249716 no 207 0.0990406939510286 552 2255129
SGTC_1996 st072960 66.8 µM 1.28590043183826 0.0672356372442499 no 208 0.0992389064919763 587 1719405
SGTC_1483 3453-0561 55.9 µM 1.2856966587817 0.0672656570167097 no 209 0.09927447388974 613 4546991
SGTC_988 1497-1057 103 µM 1.28186753628638 0.0678316907625946 no 210 0.0999445588885212 557 3533044
SGTC_2101 5377231 179.231 µM 1.28039348361058 0.0680505682430866 no 211 0.100203392296377 548 2844213
SGTC_1417 3966-0327 90.4 µM 1.27924132529513 0.0682220279751164 no 212 0.100406043737843 623 651118
SGTC_3226 9131256 49.47 µM 1.27671849289475 0.0685986302936391 no 213 0.100850825094662 420 17178073
SGTC_658 3253-0951 102 µM 1.27531217530401 0.0688092569075041 no 214 0.101099384999307 678 1184878
SGTC_350 k064-0020 19.8 µM 1.26861369655036 0.0698193495695365 no 215 0.10228943844173 613 2790705
SGTC_2976 9009005 19.48 µM 1.26627637024769 0.070174478342145 no 216 0.1027070768883 568 2993148
SGTC_1138 3761-0006 1.03 µM 1.26293552416369 0.0706844900220163 no 217 0.103306175982448 538 12061087
SGTC_1010 4112-3296 15.2 µM 1.26224434752475 0.0707903593956288 no 218 0.103430437732044 616 704384
SGTC_1998 st075797 76.8 µM 1.25788917506615 0.071460257353381 no 219 0.104215919540702 627 24208315
SGTC_1406 3909-7906 11.9 µM 1.25489638418424 0.0719234112888643 no 220 0.104758188390183 590 X1406
SGTC_443 clozapine 122 µM 1.2469885308051 0.0731582789490977 no 221 0.106200851499272 499 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1273 0849-0096 14.1 µM 1.24669725920082 0.0732040709373506 no 222 0.106254262089558 573 5286025
SGTC_2219 9098279 200 µM 1.2461785534786 0.0732856730597365 no 223 0.106349425398664 549 902349
SGTC_1773 st048542 73.5835 µM 1.24307017452293 0.0737761379227136 no 224 0.106920987657864 608 3237138
SGTC_2523 spermine 47.74 µM 1.24260472619125 0.0738497955427576 no 225 0.107006763731276 567 1103 A DNA binding polyamine.
SGTC_3093 9117344 49.47 µM 1.24222165881209 0.0739104584523365 no 226 0.107077395293252 556 24824913
SGTC_74 000s-0487 160.283 µM 1.24208419349846 0.0739322368700196 no 227 0.107102749917817 567 677548
SGTC_11 0438-0307 1.3 µM 1.23986152216242 0.0742850522444469 no 228 0.10751330898814 565 4011476
SGTC_2973 9094665 17.96 µM 1.23985798933994 0.0742856140481018 no 229 0.107513962452348 647 25237061 YIL048W NEO1
SGTC_552 k242-0005 476 µM 1.23949343650617 0.0743436041513038 no 230 0.10758140897472 572 4088318
SGTC_1705 st027868 56.3335 µM 1.23707646144922 0.0747289515556137 no 231 0.10802934877544 570 292948
SGTC_1704 st028805 70.8 µM 1.23483242455795 0.0750880894920641 no 232 0.108446438594223 578 2876101
SGTC_1215 3852-0577 11.2 µM 1.2330667255911 0.0753715978280431 no 233 0.108775435275682 652 2884876
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.22959638384397 0.0759311876962392 no 234 0.109424142425089 576 803109
SGTC_336 4111-0029 111 µM 1.22243570086641 0.0770958332757799 no 235 0.110771452729544 548 3131175
SGTC_1489 4065-0444 182 µM 1.22122851601467 0.0772935053428473 no 236 0.110999755115679 584 2877968
SGTC_2158 5657123 3.6195 µM 1.218540354798 0.0777350647934955 no 237 0.111509349595679 602 2858827
SGTC_1033 k072-0102 21.3 µM 1.21800115545641 0.0778238642031432 no 238 0.111611766829224 621 5965931
SGTC_986 1493-0483 84 µM 1.21647381816767 0.0780758155104915 no 239 0.111902239393305 602 40079
SGTC_324 1315-0088 19.6 µM 1.21606518248592 0.078143329333434 no 240 0.11198004626301 522 6787421
SGTC_1499 4480-0877 67.3 µM 1.21567439780049 0.0782079352725697 no 241 0.112054490364501 564 2861909
SGTC_373 0844-0104 25.9 µM 1.21508119696915 0.0783060827932447 no 242 0.112167562150385 651 5375804
SGTC_131 0141-0277 33.849 µM 1.21362752411089 0.0785469938263443 no 243 0.112444995823985 612 1547771
SGTC_2476 5806916 10.51 µM 1.21311383475808 0.0786322595912958 no 244 0.112543150639263 589 2870194
SGTC_1200 1643-0193 18.4 µM 1.21189557605467 0.0788347551630118 no 245 0.112776177910685 641 5403974
SGTC_1340 1486-1359 257 µM 1.21158968147922 0.078885662109544 no 246 0.112834743182358 625 4309068
SGTC_1510 1123-0200 71.5 µM 1.21001812894083 0.0791475924302116 no 247 0.113135968260734 692 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2999 9069765 71.4286 µM 1.20823667703536 0.0794453024036107 no 248 0.113478118856141 641 2097066
SGTC_306 1672-3436 11.6 µM 1.20648212495933 0.0797393446185749 no 249 0.113815823621972 633 6797378
SGTC_893 0958-0369 48.9 µM 1.20539714672314 0.0799215856546609 no 250 0.114025011229582 659 6819948
SGTC_2362 9071156 126 µM 1.20234344135974 0.0804361994324611 no 251 0.114615246254217 607 653133
SGTC_199 4063-0024 41.6 µM 1.20147064426885 0.0805837431968375 no 252 0.114784343558218 622 306215
SGTC_1700 st030840 7.9285 µM 1.20016911694573 0.0808041421149264 no 253 0.115036833401413 669 5499307
SGTC_234 nsc-17383 10.7 µM 1.19907700657389 0.0809894295683023 no 254 0.115249001943312 688 408974
SGTC_1505 k297-0037 20.6 µM 1.19644172012042 0.0814378526286835 no 255 0.11576211438841 634 4089396
SGTC_1087 pterostilbene 9.05 µM 1.19541688271073 0.081612744836208 no 256 0.115962096374499 655 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1714 st033236 13.627 µM 1.19446473649825 0.0817754856594986 no 257 0.116148113421724 638 2916566
SGTC_2711 st079103 59.1 µM 1.19246665480242 0.0821177928369185 no 258 0.116539159031105 597 54693780
SGTC_2555 cholic acid 100 µM 1.18895318941397 0.082722328500262 no 259 0.117229043910317 617 6708657 Influences liver metabolism.
SGTC_2915 7971052 15.16 µM 1.18332647607006 0.083697442393769 no 260 0.118339891866723 461 5741558
SGTC_1004 4084-0029 199 µM 1.18174845548117 0.0839724590152156 no 261 0.118652762761259 674 716894 YLR208W SEC13
SGTC_3287 9117173 37.0625 µM 1.18097469972381 0.0841075564510438 no 262 0.11880638708302 577 2789709
SGTC_1619 st003326 88.7 µM 1.18048394791535 0.0841933260372655 no 263 0.118903895540822 594 2849032
SGTC_3081 9117243 49.47 µM 1.17712407822382 0.0847823007353145 no 264 0.119572992960482 610 45595589
SGTC_2382 9035899 200 µM 1.17696872412604 0.0848096083645122 no 265 0.119603994887522 664 6462679
SGTC_2861 9024595 19.48 µM 1.17142326867212 0.085788694724294 no 266 0.120714341897754 529 16482810
SGTC_967 1306-0166 352 µM 1.17100485491311 0.0858629102608904 no 267 0.120798412847089 636 4437607
SGTC_784 4579-0127 173 µM 1.16975793077213 0.0860843666040224 no 268 0.121049198925629 675 1948547
SGTC_435 c-PAF 6.7 µM 1.16421922003763 0.0870732198715761 no 269 0.122167591570546 668 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3133 9127736 49.47 µM 1.16382559637432 0.0871438169936761 no 270 0.122247348423565 669 27243420
SGTC_2350 9023895 38.85 µM 1.16353841917295 0.0871953497107139 no 271 0.122305559928356 643 2997209
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.16254406750336 0.0873739576543063 no 272 0.122507267695155 715 1273210
SGTC_3119 9125183 49.47 µM 1.16185908717778 0.0874971543103708 no 273 0.122646354097069 505 22695334
SGTC_276 colchicine 750 µM 1.15770706435273 0.0882466892168611 no 274 0.123491800052 673 2833 A microtubule depolymerizer.
SGTC_2845 9003024 42.97 µM 1.15586093801652 0.0885814900053354 no 275 0.123869021251951 671 2990173
SGTC_1422 4031-0024 15.5 µM 1.15308296054317 0.0890870666866688 no 276 0.124438167397417 659 782427
SGTC_635 k038-0028 24.7 µM 1.15196147095034 0.0892917790382143 no 277 0.124668453124441 667 4035102
SGTC_2369 9071472 200 µM 1.14726162503201 0.0901534779805126 no 278 0.125636754532698 676 17296037
SGTC_793 0488-0545 106 µM 1.14408867157261 0.090738710244038 no 279 0.126293432635913 677 292548
SGTC_1388 3346-4487 254 µM 1.14025162648484 0.0914501907054221 no 280 0.127090742323497 711 3345614
SGTC_3233 9132340 49.47 µM 1.13770643603841 0.0919244060508531 no 281 0.127621542528141 660 17682950
SGTC_3176 9106582 49.47 µM 1.13579207568511 0.0922822845031727 no 282 0.128021797151391 509 17018027
SGTC_3343 9148379 18.9835 µM 1.13394396961701 0.0926287543977074 no 283 0.128409025838036 676 1955036
SGTC_2563 tomatine 8.54 µM 1.13333753963437 0.0927426530187085 no 284 0.128536266474337 737 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2750 bromebric acid 70.15 µM 1.1330170324584 0.0928028919369282 no 285 0.128603550359032 741 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_770 0389-1121 67.2 µM 1.13278467302905 0.0928465816853523 no 286 0.12865234471909 725 6753108
SGTC_2488 5268135 45.7 µM 1.13271419439429 0.0928598365474616 no 287 0.128667147431545 765 1270356 YLR208W SEC13
SGTC_2667 digitoxin 100 µM 1.13140360627391 0.0931065728083631 no 288 0.128942627167542 590 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3348 9149464 3.537 µM 1.13030973577913 0.0933128796917788 no 289 0.129172866806205 689 1951442
SGTC_1397 3532-0190 20.1 µM 1.12939643816611 0.0934853885981606 no 290 0.129365317363874 589 5322280
SGTC_797 k781-0471 270 µM 1.1282352321544 0.0937050638551808 no 291 0.129610294111071 706 23738129
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.12804874020729 0.0937403796186944 no 292 0.129649667782528 581 1241132 A phosphatase inhibitor.
SGTC_1272 0839-0021 27 µM 1.1274086201914 0.0938616731495011 no 293 0.129784878058571 703 5027250
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.12543274983874 0.0942368027445502 no 294 0.130202849870997 721 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2664 lyso-paf C-16 73.48 µM 1.12497844777052 0.0943232105828434 no 295 0.130299083606259 714 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1736 st036774 51 µM 1.12412657924752 0.094485392681073 no 296 0.130479665521012 714 1272247
SGTC_218 alverine citrate 93.75 µM 1.12336732476209 0.0946301157596875 no 297 0.13064076062179 655 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_110 0850-0284 111.64 µM 1.12322909251377 0.0946564820693809 no 298 0.130670104890803 546 3906265
SGTC_2361 9034121 116 µM 1.12319321690414 0.0946633258397148 no 299 0.130677721394904 660 6496917
SGTC_1041 0206-0046 107 µM 1.12267580731973 0.0947620694610561 no 300 0.130787603201675 682 50494
SGTC_255 tunicamycin 200.472 nM 1.12065305517499 0.095148824513104 no 301 0.131217786018454 683 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1296 1068-0102 11.9 µM 1.11782044501014 0.0956923783413025 no 302 0.131821843876729 693 767053
SGTC_2827 7993847 71.43 µM 1.11760980557142 0.0957328893347738 no 303 0.131866839524421 628 2985692
SGTC_2050 5263056 171 µM 1.11352013655854 0.0965219326311822 no 304 0.132742552474482 759 763468 YGL055W OLE1
SGTC_49 0717-0965 32.132 µM 1.11052890860145 0.0971020654626853 no 305 0.133385589018124 703 5889349 YGL099W LSG1
SGTC_3183 9108214 49.47 µM 1.10846553404769 0.0975037348923922 no 306 0.133830408045816 582 4974831
SGTC_3180 9109287 49.47 µM 1.10707809191322 0.0977745074315873 no 307 0.134130083308323 639 18891271
SGTC_2745 rifampicin 24.3 µM 1.1050140331019 0.0981783475587629 no 308 0.134576754252298 561 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_185 k048-0037 25.491 µM 1.10234818488363 0.0987017362735378 no 309 0.135155164335114 741 6827589
SGTC_2796 7949634 45.45 µM 1.09913348417293 0.0993355942320449 no 310 0.135854923276524 657 2971588
SGTC_1553 gossypol 38.6 µM 1.09848771682076 0.0994632814318207 no 311 0.135995789180958 599 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_366 0181-0206 4.31 µM 1.09736602834814 0.0996853573297654 no 312 0.136240708822414 752 274874
SGTC_3086 9117350 49.47 µM 1.09558961394133 0.100037799041243 no 313 0.136629204452183 645 2679265
SGTC_2186 6124449 200 µM 1.09391910303162 0.100370058745095 no 314 0.136995229852126 711 3834182 YLR033W RSC58
SGTC_1424 4048-1941 275 µM 1.09289193614777 0.100574758639126 no 315 0.137220624612049 785 X1424
SGTC_38 0929-0051 58.268 µM 1.09223022034459 0.100706790472997 no 316 0.137365961262541 766 1379719
SGTC_2262 9014885 67.46 µM 1.09189098782531 0.100774526368172 no 317 0.137440509698114 639 6457424
SGTC_1636 st007707 68.9 µM 1.08990017317321 0.101172709879757 no 318 0.137878560163391 755 403051
SGTC_2713 st079149 53.4 µM 1.08940666897063 0.101271592918273 no 319 0.137987295905504 745 3103253
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.0867865827955 0.101797756967969 no 320 0.13856556936683 691 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1522 st012842 45.6 µM 1.08529129918161 0.102098929350546 no 321 0.13889632914592 653 3491067 YOR116C RPO31
SGTC_3342 9147791 14.508 µM 1.08344319655252 0.102472059839274 no 322 0.139305875508156 724 1838168
SGTC_1427 4048-4900 550 nM 1.07939875556564 0.103292086361251 no 323 0.140205002730597 736 24132586
SGTC_2474 5321570 43.32 µM 1.07893315852876 0.103386792963749 no 324 0.140308762925578 716 2841384
SGTC_2252 omeprazole 400 µM 1.07647087085871 0.103888692559363 no 325 0.140858360779065 631 4594 A proton pump inhibitor.
SGTC_1344 1488-0097 29.1 µM 1.07636080627733 0.103911168726453 no 326 0.14088296193018 702 747966
SGTC_2648 atorvastatin 78.68 µM 1.07618243305779 0.103947601613985 no 327 0.140922837316985 707 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2435 5706476 10.6 µM 1.07505554955831 0.104177982704891 no 328 0.141174929418848 766 5725375
SGTC_2843 9000894 45.46 µM 1.07466534968483 0.10425784173183 no 329 0.141262291215568 580 2242070
SGTC_179 1273-0063 6.77 µM 1.07404285092502 0.104385335318817 no 330 0.141401738234837 671 3108139
SGTC_2444 5485484 36.41 µM 1.07268351830197 0.104664132029685 no 331 0.141706568878408 757 6790631
SGTC_2473 5854593 8.94 µM 1.07062769431059 0.105086801878189 no 332 0.142168432954073 702 2872951
SGTC_2443 5493264 126.67 µM 1.06818371367714 0.105590880876769 no 333 0.142718824880972 738 5340055
SGTC_1744 st037937 38.9 µM 1.06783774477574 0.105662379130814 no 334 0.142796854376211 719 1016152
SGTC_532 1548-0774 215 µM 1.06783406735659 0.105663139297631 no 335 0.14279768393267 758 5932993
SGTC_102 gallobenzophenone 83.616 µM 1.06559521252935 0.106126671825469 no 336 0.143303332152782 731 70837
SGTC_2994 9053520 71.4286 µM 1.06558031928263 0.106129760234274 no 337 0.143306699855054 742 4647384
SGTC_1445 4239-0156 97.7 µM 1.06418434364791 0.106419531680165 no 338 0.143622599036705 821 4008346
SGTC_2629 bisabolol 100 µM 1.06269296799362 0.106729736612264 no 339 0.143960605434094 765 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3195 9113082 49.47 µM 1.0622249142763 0.106827225810056 no 340 0.144066795975101 722 17018038
SGTC_3069 9117009 49.47 µM 1.06206388182256 0.106860781522278 no 341 0.144103342716459 598 41904981
SGTC_2213 7173844 200 µM 1.06151429596495 0.10697536070197 no 342 0.144228119753655 760 892728
SGTC_871 0574-0004 149 µM 1.06060746260951 0.107164613537086 no 343 0.14443416485388 780 9551173
SGTC_994 3910-0338 138 µM 1.05758401370464 0.107797340511153 no 344 0.145122566945073 771 3479481
SGTC_3322 9139058 2.11 µM 1.05753264162948 0.107808114512099 no 345 0.145134282780695 762 4908926 YPR165W RHO1
SGTC_609 0986-0026 86.3 µM 1.05463321689646 0.108417453740529 no 346 0.14579655293371 760 2848610
SGTC_1615 st002656 86.5 µM 1.04820907416076 0.109776361822825 no 347 0.147271145360932 752 1584458
SGTC_1579 chlormadinone acetate 49.4 µM 1.04804806240298 0.10981057721708 no 348 0.14730823182715 784 45114258 A steroidal progestin.
SGTC_282 k297-0036 65.7 µM 1.04803993474198 0.109812304567938 no 349 0.147310104068952 732 5061378
SGTC_1882 5615643 20 µM 1.04708385470451 0.110015633895514 no 350 0.147530452515121 722 2253075
SGTC_41 0478-0632 82.643 µM 1.04635566908862 0.110170678084376 no 351 0.147698426030685 839 3750424
SGTC_2341 7987486 176.74 µM 1.04580653003363 0.110287703567295 no 352 0.147825182835985 782 1258686
SGTC_875 0709-0210 25.7 µM 1.04496699196448 0.110466787451233 no 353 0.148019112696971 810 6251364
SGTC_3018 9082602 49.47 µM 1.04368954882464 0.110739681711454 no 354 0.148314523374941 783 17332089
SGTC_1755 st041960 45.185 µM 1.04333401277864 0.110815719092776 no 355 0.148396811736944 754 2257073
SGTC_270 tamoxifen 5.46 µM 1.04302296584272 0.110882272399937 no 356 0.14846882818996 823 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.04301811597621 0.110883310330624 no 357 0.148469951260765 834 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1498 4478-3555 97.6 µM 1.04269123898045 0.110953282045686 no 358 0.148545658400213 728 3437919
SGTC_2946 9065502 71.43 µM 1.04141510465617 0.111226755777802 no 359 0.148841467642354 597 16489101
SGTC_1122 capsaicin 818.572 nM 1.03994021832469 0.11154342255905 no 360 0.149183837866797 784 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1302 1159-0335 255 µM 1.03738192514959 0.112094232176666 no 361 0.149778949295982 742 649284
SGTC_3076 9116187 49.47 µM 1.03674245189517 0.1122322162801 no 362 0.149927950930254 716 27241210
SGTC_728 3030-5151 22.5 µM 1.03568884156794 0.112459826646847 no 363 0.150173664864208 731 3125388
SGTC_1746 st038117 42 µM 1.03459288856624 0.112696933968746 no 364 0.15042953825375 745 2898218
SGTC_1923 st058458 19.1 µM 1.03448384150912 0.112720545602026 no 365 0.150455013472303 823 3534982
SGTC_73 0327-0325 16.231 µM 1.03384610112483 0.112858704361397 no 366 0.15060405785818 848 53298
SGTC_2770 toltrazuril 17.5 µM 1.02932611305509 0.113841370649801 no 367 0.151663228223718 808 68591 Kills coccidiodes.
SGTC_1066 ketoconazole 628 nM 1.02921346935596 0.113865937539293 no 368 0.151689687135935 811 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1407 3909-7909 12.3 µM 1.02691443677115 0.114368167857232 no 369 0.152230377855052 812 4411780
SGTC_2697 mebhydrolin 72.4 µM 1.02471641393079 0.114849805163504 no 370 0.152748507950487 810 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2182 6325192 200 µM 1.02449989282227 0.114897327864447 no 371 0.152799610713915 751 736248
SGTC_2237 6667747 47.222 µM 1.02256291308483 0.115323084304354 no 372 0.153257276141806 741 729940 YDL015C TSC13
SGTC_410 α-linolenic acid 100 µM 1.01951480554173 0.115995340028048 no 373 0.153979313952207 813 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1410 3909-8106 77.9 µM 1.0187187272501 0.116171371208842 no 374 0.154168259622197 773 1039210
SGTC_2738 aclarubicin 5.55 µM 1.01631674499462 0.116703653367374 no 375 0.154739288577879 698 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_653 0203-0016 55.2 µM 1.01470871566408 0.117060959518147 no 376 0.155122349141942 803 295302
SGTC_1805 st050013 60.3 µM 1.01335827133353 0.117361628233903 no 377 0.155444531739182 756 4037144
SGTC_1230 0170-0365 3.77 µM 1.01312968889844 0.117412574879345 no 378 0.155499109511354 918 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_502 l-744,832 89.3 µM 1.01014405424317 0.118079454146575 no 379 0.156213139179561 801 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_839 0122-0028 230 µM 1.00959028826505 0.118203438728244 no 380 0.156345812224196 835 759448
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.0095718781754 0.118207562207445 no 381 0.156350224247353 787 390807
SGTC_1129 3453-1384 223 µM 1.00920761647651 0.118289170209012 no 382 0.156437537320227 832 1084452
SGTC_176 1486-1328 72.834 µM 1.00879479566837 0.118381705378039 no 383 0.156536528759084 796 22310231
SGTC_466 geldanamycin 89.2 µM 1.00826299435352 0.11850098582936 no 384 0.156664111633929 681 5288382 HSP90 inhibitor.
SGTC_2129 girgensonine 121.053 µM 1.00646137910512 0.118905710602334 no 385 0.157096840381594 840 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2847 9005661 71.43 µM 1.00629463188363 0.118943218914844 no 386 0.15713693099165 700 2991449
SGTC_898 1000-0849 28.3 µM 1.00535398812831 0.119154964920927 no 387 0.157363213596692 823 6751807
SGTC_2441 5730946 39.09 µM 1.00496553298911 0.119242486693528 no 388 0.157456723381958 802 1774275
SGTC_2886 9058944 51.95 µM 1.00410858247529 0.11943572431952 no 389 0.157663139534777 643 4949929
SGTC_575 k072-0246 11.9 µM 1.00319561256036 0.119641836982414 no 390 0.157883244738059 820 6796779
SGTC_111 0083-0039 52.457 µM 1.00281644006925 0.119727512892248 no 391 0.157974717582451 687 759313
SGTC_692 k241-0027 77.8 µM 1.00198577916763 0.119915356042853 no 392 0.158175230591082 778 3600480
SGTC_281 1672-3440 14.9 µM 0.999948004307468 0.120377052025747 no 393 0.158667835693941 859 6833000
SGTC_1398 3558-0053 112 µM 0.99964631016331 0.120445512739635 no 394 0.158740851652341 723 4532369
SGTC_2640 pentamidine 10.38 µM 0.998860938577892 0.120623858575418 no 395 0.158931030422782 867 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_910 3454-3003 490 µM 0.996387412046181 0.121186773141 no 396 0.159530973407359 826 820824
SGTC_46 0329-0187a 2.197 µM 0.995666336362837 0.121351219723207 no 397 0.159706145837042 891 46494817
SGTC_1971 st069429 63.5 µM 0.994174758213529 0.121691882842429 no 398 0.16006889733354 795 1246522 YGL099W LSG1
SGTC_1295 1013-0063 9.78 µM 0.993292648339051 0.121893664800459 no 399 0.160283679589587 843 6826038
SGTC_3246 9135460 32.98 µM 0.991792258927402 0.12223741736275 no 400 0.160649437316332 732 41446951
SGTC_522 1273-0010 11.6 µM 0.990254441342851 0.122590450688796 no 401 0.161024884333634 790 5705015
SGTC_2137 5261020 140 µM 0.990008730640322 0.122646924152855 no 402 0.1610849258358 804 763655
SGTC_1875 nocodazole 6 µM 0.989294121602017 0.122811271617722 no 403 0.161259629656562 829 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3244 9134489 49.47 µM 0.988292694539994 0.12304184193461 no 404 0.161504661110974 792 16584271
SGTC_2670 beta-carotene 100 µM 0.986955798679549 0.123350123882511 no 405 0.161832153993574 763 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_739 1486-1183 203 µM 0.986422557784927 0.123473237588804 no 406 0.161962900055217 837 4346692
SGTC_464 bw-b 70c 158 µM 0.984546088933358 0.123907157623738 no 407 0.162423540966884 851 5353454
SGTC_2866 9034245 58.44 µM 0.984202142134713 0.123986808470155 no 408 0.162508066381792 805 6462273
SGTC_1790 st045711 43.5 µM 0.984031386779412 0.124026365127214 no 409 0.162550040383728 802 585119
SGTC_3235 9132602 49.47 µM 0.983873789885684 0.124062881371482 no 410 0.162588786114887 838 4912240
SGTC_3199 9111318 49.47 µM 0.982265013804205 0.124436075833595 no 411 0.162984652882727 810 8548020
SGTC_426 0988-0037 14.6 µM 0.982248944731702 0.124439807398204 no 412 0.162988610109785 867 5383008
SGTC_2073 5212005 126 µM 0.982217439239898 0.124447123839607 no 413 0.162996368945752 732 691789
SGTC_1939 st074455 53.6 µM 0.978621113503951 0.125284267060567 no 414 0.163883611537223 837 1644229
SGTC_183 3914-0051 30.55 µM 0.978352864576303 0.125346866531098 no 415 0.163949916082876 844 1596232
SGTC_916 4466-0038 42 nM 0.977937247114348 0.125443899535157 no 416 0.164052680881233 938 5722064 YGL116W CDC20
SGTC_2263 7948595 193.29 µM 0.977910478910442 0.125450150826686 no 417 0.164059300969396 763 2971371
SGTC_3125 9127534 49.47 µM 0.9759905703954 0.125899082313291 no 418 0.164534568615799 718 1639235
SGTC_683 panaxydol 45 µM 0.973953965400969 0.126376524175139 no 419 0.165039698442464 854 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1456 k015-0012 13 µM 0.972529111693298 0.126711302178747 no 420 0.165393694700408 908 2989616
SGTC_780 0109-0199 192 µM 0.968748073800505 0.127602671972418 no 421 0.166335450136798 878 610414
SGTC_415 dibenzyl ketone 100 µM 0.966518771715937 0.128130262325859 no 422 0.166892329193019 843 7593
SGTC_2566 crystal violet carbinol 226 nM 0.963358291164949 0.128880820470744 no 423 0.167683874897281 696 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2958 9077254 16.72 µM 0.96002743174626 0.12967513529117 no 424 0.168520704514019 801 16457351
SGTC_132 0417-1715 25.805 µM 0.959998417462565 0.129682069232621 no 425 0.16852800570373 872 6769098
SGTC_577 r071-0003 38.6 µM 0.958005544062831 0.130158948196731 no 426 0.169029981472772 984 4568517 YMR134W ERG29
SGTC_1751 st044839 27.194 µM 0.957082607293883 0.130380210350147 no 427 0.169262780808291 838 5291326
SGTC_223 busulfan 5 mM 0.956472919020021 0.130526517854083 no 428 0.169416679943483 758 2478 A DNA alkylator.
SGTC_887 0885-0007 9.62 µM 0.955933714759828 0.130656005811772 no 429 0.169552862121645 862 5719458
SGTC_1256 0570-0116 285 µM 0.955317979717285 0.130803980941906 no 430 0.169708458888153 796 410638
SGTC_2128 5255449 168.493 µM 0.953361438286613 0.131274950977741 no 431 0.170203486196692 884 736008
SGTC_462 ag-879 158 µM 0.9527207913519 0.13142941887875 no 432 0.170365778050853 881 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3303 9125618 40.5795 µM 0.950817359474893 0.131889099925965 no 433 0.170848549355911 908 22695467
SGTC_757 1066-0008 322 µM 0.946073834505266 0.1330394884845 no 434 0.172055464179818 886 6842497
SGTC_512 prima-1 270 µM 0.943412953145917 0.133687814430034 no 435 0.172734860119922 902 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1558 st069300 45.6 µM 0.943076293936054 0.133769996261403 no 436 0.172820940148496 800 24208000
SGTC_2839 9003951 25.97 µM 0.942276744323312 0.133965313360423 no 437 0.173025485667806 834 2990634
SGTC_2584 androsterone 48.74 µM 0.939517422224812 0.134640876027819 no 438 0.173732575756592 1003 2754130 A steroid.
SGTC_3010 9080089 71.4286 µM 0.938416469818194 0.134911072785289 no 439 0.174015212620233 881 17027233
SGTC_3029 9088683 49.47 µM 0.937389381963999 0.135163476783717 no 440 0.174279150365795 862 25236615
SGTC_1851 st056236 18.9 µM 0.935852991364437 0.135541644607279 no 441 0.174674441684603 908 5393171
SGTC_2223 6903751 107.57 µM 0.932299076138099 0.136419182724535 no 442 0.175590992523721 816 5598863
SGTC_1012 4112-3522 18 µM 0.932022803614843 0.136487562789646 no 443 0.175662370348167 913 3112398
SGTC_3271 9137798 49.47 µM 0.931772004192095 0.136549658318876 no 444 0.17572718285477 797 6498326
SGTC_1500 4488-1866 171 µM 0.931350020318528 0.136654181070898 no 445 0.17583626765953 939 2900003
SGTC_1659 st012954 42.1 µM 0.928855273816153 0.13727323171514 no 446 0.176482047321809 863 24207262
SGTC_935 2996-0153 430 µM 0.927956336823419 0.137496764160688 no 447 0.176715109607532 883 23738523
SGTC_3340 9146634 11.102 µM 0.926296646275672 0.137910120559722 no 448 0.17714591916566 866 4907387
SGTC_2669 eugenol 100 µM 0.922346680978188 0.138897291114311 no 449 0.178173885992216 834 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_959 1222-0044 107 µM 0.91986598499922 0.139519717609636 no 450 0.178821398056867 907 6083612
SGTC_323 4013-0906 34.3 µM 0.91712104864152 0.140210651891922 no 451 0.179539606197392 908 2910086
SGTC_3265 9137266 49.47 µM 0.916835195840571 0.140282737951023 no 452 0.179614503211468 879 17224265
SGTC_2828 7998861 71.43 µM 0.913876852746178 0.141030247985768 no 453 0.180390778885589 827 2988188
SGTC_567 1080-0542 68.4 µM 0.913737274568032 0.141065583016927 no 454 0.180427456428317 844 5950415
SGTC_2919 7978188 46.38 µM 0.910663463718537 0.141845258287172 no 455 0.181236360257479 917 2980291
SGTC_559 1550-0661 158 µM 0.910389799054913 0.141914814804484 no 456 0.181308487772499 893 5830875
SGTC_2570 licareol 100 µM 0.908147903146012 0.142485500169749 no 457 0.181900042193047 836 443158
SGTC_1250 0485-0349 40.2 µM 0.906277461786532 0.142962816151032 no 458 0.182394505881976 856 6842794 YDL195W SEC31
SGTC_911 3456-4043 236 µM 0.905302261180118 0.143212104626275 no 459 0.182652639415571 922 914281
SGTC_718 1130-0073 349 µM 0.905300565793221 0.143212538269957 no 460 0.182653088379431 916 6740020
SGTC_1912 st060209 90.8 µM 0.905006777150639 0.143287696509711 no 461 0.182730898420674 844 688787
SGTC_662 k832-1615 104 µM 0.902115833916666 0.144028690345335 no 462 0.183497669268766 882 5878478
SGTC_2048 5246248 200 µM 0.899995552379056 0.144573791466961 no 463 0.184061308795458 917 677046
SGTC_1662 st014054 52 µM 0.899584398853055 0.144679655205865 no 464 0.184170731362924 894 2838777
SGTC_2944 9067346 25.62 µM 0.898336463330719 0.145001293112122 no 465 0.18450309923663 845 6473075
SGTC_925 2064-1272 59.6 µM 0.897763708859766 0.145149073585977 no 466 0.184655768150193 852 6815817
SGTC_69 0096-0274 206.684 µM 0.897555545092438 0.145202808511395 no 467 0.184711274097646 969 6741392
SGTC_333 3486-0131 40.1 µM 0.896225379529424 0.145546490481837 no 468 0.185066201723771 965 6744690
SGTC_1480 1070-0044 41.2 µM 0.895843923187337 0.145645150238349 no 469 0.185168063710324 930 3124987
SGTC_1237 0330-0133 46.1 µM 0.895432978670455 0.145751487108727 no 470 0.185277839011276 881 X1237 YHR072W ERG7
SGTC_2742 clothiapine 36.27 µM 0.894912386126227 0.145886271649159 no 471 0.185416962517117 867 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2663 amphotericin b 100 µM 0.894294167744673 0.14604644087165 no 472 0.185582259824482 912 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1814 st052110 31.539 µM 0.894039618157593 0.146112424398149 no 473 0.185650347070211 916 674163
SGTC_958 1222-0007 33 µM 0.892936659180281 0.146398561225993 no 474 0.185945546970881 970 7312461
SGTC_2638 epoxomicin 18 µM 0.892825516911873 0.146427415330211 no 475 0.185975309620116 954 9915668 A protesome inhibitor.
SGTC_1451 4152-0210 104 µM 0.890284313696059 0.147088189239194 no 476 0.186656620892442 953 659563
SGTC_1812 st052057 4.327 µM 0.890066644758051 0.147144881209032 no 477 0.18671505095633 965 3645418
SGTC_1979 st071809 45.3 µM 0.889501044154505 0.147292260612699 no 478 0.186866931148519 937 4976333
SGTC_3260 9137109 49.47 µM 0.889431518599714 0.147310383817422 no 479 0.186885606054821 800 17478346
SGTC_1855 st056195 39.6 µM 0.889305489205761 0.147343239670153 no 480 0.186919461114573 891 4028379
SGTC_2447 5741742 33.78 µM 0.888878156365396 0.147454681862212 no 481 0.187034283048274 936 1776504
SGTC_368 fentichlor 4.58 µM 0.887393080689708 0.147842407080141 no 482 0.187433653732573 841 7329 A pesticide.
SGTC_1345 1488-0192 31.4 µM 0.886934131410937 0.147962368016856 no 483 0.187557182187422 958 658348
SGTC_2616 abietic acid 100 µM 0.886024809011034 0.148200240625997 no 484 0.187802079316369 970 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3071 9117417 49.47 µM 0.885193918227296 0.148417819647923 no 485 0.188026025964798 845 45595590 YGL055W OLE1
SGTC_2212 7123476 200 µM 0.883915422588426 0.148753026607567 no 486 0.188370935564589 867 1085715
SGTC_425 3825-7017 13.1 µM 0.881160111767443 0.149477156776827 no 487 0.189115582711225 953 3397440
SGTC_2505 galangin 7.89 µM 0.8798548375037 0.149821019130907 no 488 0.189468976578367 864 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3230 9131665 49.47 µM 0.879681250075798 0.149866788841166 no 489 0.189516004755745 868 15943720
SGTC_3297 9117502 71.43 µM 0.878676600009725 0.1501318675778 no 490 0.189788324861308 956 7453720
SGTC_321 4534-3890 65.3 µM 0.877964585581022 0.150319923006835 no 491 0.189981468877078 962 699746
SGTC_2754 granisetron 64.02 µM 0.877847724548007 0.150350803032992 no 492 0.19001318062899 929 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2708 st078559 56 µM 0.876717550487151 0.150649664779449 no 493 0.190320035829729 848 17250902
SGTC_289 k017-0060 526 µM 0.874389355763561 0.151266575685023 no 494 0.190953126049294 951 5512909
SGTC_3261 9137475 49.47 µM 0.872712803749046 0.151711857520049 no 495 0.191409818543705 772 17027690
SGTC_2378 9074213 121.43 µM 0.870430864559311 0.15231932482488 no 496 0.192032492829213 982 657714
SGTC_474 dl-dihydrosphingosine 5 µM 0.870317271204978 0.152349606256468 no 497 0.192063521478915 974 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3042 9091578 49.47 µM 0.868022144456428 0.152962291369594 no 498 0.192691105005167 926 25236497
SGTC_975 1335-0046 28.5 µM 0.867932478519548 0.152986260842304 no 499 0.192715648825676 951 16486740
SGTC_2551 apiole 73.87 µM 0.867211329670191 0.153179128691676 no 500 0.19291311484619 826 10659 A possible DNA adduct former.
SGTC_3284 9108171 64.8615 µM 0.866513041876429 0.153366035948583 no 501 0.193104438739235 889 8687505
SGTC_2080 5212524 12.4 µM 0.864357168959079 0.153944040754532 no 502 0.19369585697622 937 260183
SGTC_357 1325-0123 420 µM 0.863812637354556 0.154090261269686 no 503 0.193845412255809 953 1098503
SGTC_22 0964-0034 14.468 µM 0.859268925039215 0.155313943947702 no 504 0.195096082189593 997 138402
SGTC_2011 4012611 177 µM 0.85647593329757 0.156069308258103 no 505 0.195867289665985 963 2049887
SGTC_2027 5150920 200 µM 0.85638782664855 0.156093176015777 no 506 0.195891647942399 957 786715
SGTC_702 1488-0190 94 µM 0.855711382583004 0.156276502272766 no 507 0.196078721287733 970 949357
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.85443032235156 0.156624076866854 no 508 0.196433300470939 1005 6708739 YPR165W RHO1
SGTC_2685 mycophenolic acid 18.85 µM 0.852167115305561 0.157239368212772 no 509 0.197060672799764 966 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_530 4358-1714 28 µM 0.851863474089446 0.157322038996005 no 510 0.197144935830841 996 1564641
SGTC_3315 9136395 68.55 µM 0.847654095228195 0.158471047517404 no 511 0.1983153192028 1022 16876844
SGTC_2302 7771753 200 µM 0.844491410255575 0.159337958776311 no 512 0.199197430660758 981 2203047
SGTC_72 0744-0168 198.391 µM 0.843051399492469 0.159733701416394 no 513 0.199599849009893 942 677577
SGTC_810 3825-7150 143 µM 0.84287572733464 0.159782023477287 no 514 0.199648974949663 1035 22330411 YGL099W LSG1
SGTC_2771 fluoxetine 41.05 µM 0.842295135307627 0.159941794691061 no 515 0.199811386683426 951 3386 A selective serotonin reuptake inhibitor.
SGTC_2148 5546263 113.568 µM 0.839863802246148 0.160611999807243 no 516 0.200492377641896 980 792097
SGTC_791 1348-1292 225 µM 0.837030343790027 0.161395363245712 no 517 0.201287756008392 1044 5437054
SGTC_2238 6671620 73.2395 µM 0.832533547038911 0.162643694529083 no 518 0.202553925346818 1036 729941
SGTC_956 1185-0240 191 µM 0.83200382200272 0.162791161066505 no 519 0.202703393590567 969 1416193
SGTC_2313 7726885 200 µM 0.831516863934162 0.162926798683578 no 520 0.202840852749567 948 726423
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.830792343393669 0.16312874305739 no 521 0.203045474383385 937 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2576 guaiol 23.12 µM 0.830677448581315 0.163160782430157 no 522 0.203077934698426 1027 227829
SGTC_1841 st054148 70 µM 0.829408034583545 0.16351504123263 no 523 0.20343677829283 912 675442
SGTC_165 k038-0023 64.381 µM 0.828763794827709 0.163695021904957 no 524 0.203619039467286 1041 46368543
SGTC_1560 lithocholic acid 53.1 µM 0.827424246703311 0.164069661784115 no 525 0.203998321168955 957 9903 A bile acid which acts as a detergent.
SGTC_2330 7979373 200 µM 0.82720508303089 0.164131009574744 no 526 0.204060415549979 976 1863007
SGTC_918 glabranin 770.725 nM 0.82501187572696 0.164745746411814 no 527 0.204682424242084 997 124049 Also referred to as licorice root.
SGTC_1920 st075728 45.7 µM 0.823534811562677 0.165160594016656 no 528 0.205101964668359 990 3400306
SGTC_1413 3910-0535 34.4 µM 0.822248815700343 0.165522328402879 no 529 0.205467650530029 1036 2876951
SGTC_2519 cryptotanshinone 88.04 µM 0.821712794509265 0.16567325559014 no 530 0.205620187796549 1012 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1135 dihydrocapsaicin 536.708 nM 0.820880225994517 0.165907857835707 no 531 0.205857247730962 935 107982 A Capsaicinoid.
SGTC_2479 5617353 43.85 µM 0.819702378017915 0.166240119936646 no 532 0.206192897023141 988 2731746
SGTC_1399 3562-5772 25 µM 0.819274132272062 0.166361031321868 no 533 0.206315013848016 931 23847490
SGTC_1691 st019933 84.6 µM 0.817876534637488 0.166756025571572 no 534 0.206713845226799 1018 6176082
SGTC_1919 st067113 52.3 µM 0.815149065387303 0.167528614302604 no 535 0.207493494548357 982 1268243
SGTC_152 4469-0003 551.229 µM 0.812685100590287 0.16822854147728 no 536 0.208199312898551 1037 697280
SGTC_608 k048-0125 159 µM 0.812331724065012 0.168329077551195 no 537 0.208300655881765 1042 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1319 1306-0155 43.7 µM 0.81226246874469 0.168348785306379 no 538 0.208320520658502 1047 3122360
SGTC_1048 3161-0300 24.5 µM 0.810709719010091 0.168791035701037 no 539 0.208766195331327 1092 2165101
SGTC_2282 7944268 200 µM 0.809330025648796 0.169184622385327 no 540 0.209162669897922 1017 2970414
SGTC_2275 7947463 200 µM 0.808610744040723 0.169390046152167 no 541 0.20936954140565 1004 1225414
SGTC_628 1636-0253 16 µM 0.807173153752737 0.169801095301139 no 542 0.209783365220841 1036 4456143
SGTC_3218 9131285 49.47 µM 0.806142855726513 0.170096080812816 no 543 0.210080241732969 1062 17156417
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.806027011008292 0.170129268941094 no 544 0.210113637383404 1000 688662
SGTC_2582 agaric acid 100 µM 0.805175083003909 0.170373463598693 no 545 0.210359326492881 1060 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1043 0916-0009 19.3 µM 0.802597943288491 0.171113534919204 no 546 0.211103578749062 1126 3101130
SGTC_1924 st058459 75.1 µM 0.801548034975284 0.171415623217887 no 547 0.211407223680186 1035 688683
SGTC_2536 dehydroabietamide 32.04 µM 0.801015294186796 0.171569038085944 no 548 0.211561395900284 1057 3983547
SGTC_3136 9095672 49.47 µM 0.800438947747585 0.171735108961583 no 549 0.211728261456829 902 17217380
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.79936936663866 0.172043574522223 no 550 0.212038133820654 991 279621
SGTC_1568 digitonin 820 nM 0.797753623844381 0.172510222514248 no 551 0.212506739319674 1062 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_946 3434-1334 87.4 µM 0.79682052687713 0.172780080652385 no 552 0.212777635930809 1010 4047976
SGTC_1275 0867-0008 21.1 µM 0.795270877688487 0.173228844111173 no 553 0.213227975053294 1056 3422836
SGTC_655 k060-0012 42 µM 0.794487988836988 0.173455843125831 no 554 0.213455699318622 1024 5994525
SGTC_1494 4358-1428 177 µM 0.789318809204014 0.174959398184738 no 555 0.214962847965721 1098 1564571
SGTC_3213 9129884 49.47 µM 0.787515370607887 0.175485903024437 no 556 0.215490117102625 1020 17190742
SGTC_3336 9143619 71.43 µM 0.786330189024486 0.175832457106163 no 557 0.21583703529336 1087 45595730
SGTC_2077 5212015 200 µM 0.785303586810678 0.176132991756098 no 558 0.216137796665248 1016 780900
SGTC_1832 st054113 55 µM 0.784180166357011 0.176462242012667 no 559 0.216467200621129 1057 1251267
SGTC_3048 9093155 49.47 µM 0.784172309728883 0.176464545990629 no 560 0.216469505326401 1037 25236002
SGTC_2167 5876490 200 µM 0.783480633374218 0.176667456573383 no 561 0.216672461008617 1071 686534
SGTC_477 mead ethanolamide 10 µM 0.783366465231359 0.176700963186578 no 562 0.216705971465533 924 16061185
SGTC_50 0929-0078 56.389 µM 0.782436495621906 0.176974044761282 no 563 0.216979046332736 982 1377751
SGTC_1854 st056233 32.9 µM 0.782424089080113 0.176977689690563 no 564 0.21698269071466 1015 5393174
SGTC_2506 ethyl hematommate 54.16 µM 0.782107242459989 0.177070792424228 no 565 0.217075775382685 1001 3940691 An allergen.
SGTC_3105 9121040 49.47 µM 0.781686344865151 0.177194517512324 no 566 0.217199464305597 884 41448907
SGTC_2384 9036245 200 µM 0.781256319758714 0.177320982058149 no 567 0.217325877559902 1079 6462766
SGTC_1086 cerivastatin 2.18 µM 0.780942952392618 0.177413175035283 no 568 0.217418024026593 1045 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1565 sinapyl alcohol 95.1 µM 0.779067147948178 0.177965671029765 no 569 0.217970080503161 1080 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2837 9008476 45.46 µM 0.778743487880885 0.178061110909956 no 570 0.218065416599847 1066 2992805
SGTC_945 3381-0768 11.3 µM 0.778289920068634 0.178194911869306 no 571 0.218199058271159 1103 1126236 YIL048W NEO1
SGTC_3277 9138724 49.47 µM 0.778025083492631 0.178273067052906 no 572 0.218277112970793 963 15943418
SGTC_788 1182-0090 188 µM 0.777666465064289 0.178378932362164 no 573 0.218382833425411 1144 5715185
SGTC_2647 atorvastatin 60.16 µM 0.777597361706779 0.178399336445403 no 574 0.218403208434172 1033 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_399 oxolinic acid 75 µM 0.77663133488425 0.17868472821789 no 575 0.218688154436457 1032 4628 A DNA gyrase inhibitor.
SGTC_3117 9124945 49.47 µM 0.775954929433803 0.178884728618755 no 576 0.218887799003497 991 17592065
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.775665927014705 0.178970224154476 no 577 0.218973131522582 1109 94937 An inhibitor of serotonin biosynthesis.
SGTC_1932 st074806 40.9 µM 0.775360088218125 0.179060728391403 no 578 0.219063456082727 1201 17251235
SGTC_848 0368-0089 85.6 µM 0.773029558006521 0.179751327506833 no 579 0.219752443937384 1088 762535
SGTC_2201 6605497 169.863 µM 0.771353447479056 0.18024903742566 no 580 0.220248730142685 1078 670741
SGTC_2460 5552655 174.22 µM 0.771298906484588 0.180265247528937 no 581 0.220264890190988 1090 5401989
SGTC_3107 9121808 49.47 µM 0.770653304988912 0.180457195948293 no 582 0.220456228251837 1051 662681
SGTC_886 0866-0150 153 µM 0.768344189142665 0.181144784647651 no 583 0.221141364139691 1130 271463
SGTC_372 0155-0182 15.9 µM 0.76530237458283 0.18205305124775 no 584 0.222045755191394 1115 771486
SGTC_2891 9063876 19.48 µM 0.764954941684565 0.182156973389814 no 585 0.22214918798667 1037 6472478
SGTC_2803 7707263 71.43 µM 0.763194701483297 0.182684056034144 no 586 0.222673644127428 1050 2199229
SGTC_2744 captopril 92.04 µM 0.763130607238939 0.182703266231825 no 587 0.222692754044458 1053 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_56 0957-0365 83.25 µM 0.76291302696386 0.182768488360571 no 588 0.222757633316037 1076 6752360
SGTC_2820 7989630 71.43 µM 0.762884238216168 0.182777119199391 no 589 0.222766218508483 986 2984098
SGTC_198 3454-2873 16.191 µM 0.762689145603091 0.182835614480883 no 590 0.222824402722559 1101 710957
SGTC_3327 9140648 26.9345 µM 0.761522370308142 0.183185696552861 no 591 0.223172561249868 1087 8029710
SGTC_1133 3473-0247 50 µM 0.761186264904153 0.183286619941849 no 592 0.223272910447495 1039 711311
SGTC_156 3474-0145 5.642 µM 0.76088475606323 0.183377184412705 no 593 0.223362952182035 1060 2265471
SGTC_749 1000-0129 128 µM 0.760417930485779 0.183517460242524 no 594 0.223502404386472 1139 708470
SGTC_865 0488-0499 301 µM 0.75612847658844 0.18480952162965 no 595 0.224786085016131 1139 9634651
SGTC_3118 9124250 49.47 µM 0.756012722440026 0.184844467050732 no 596 0.224820783938214 992 1504786
SGTC_2852 9023854 51.95 µM 0.756006223168752 0.184846429260025 no 597 0.224822732275558 1124 19798528
SGTC_799 1310-0557 151 µM 0.755335768294001 0.185048917314444 no 598 0.225023771197623 1089 5354492
SGTC_672 1441-0018 53.7 µM 0.753506240096009 0.185602164692673 no 599 0.225572881468045 1080 251141
SGTC_2981 9013952 38.96 µM 0.752728731220115 0.185837593002618 no 600 0.22580647055714 1067 2996344
SGTC_2834 9001755 58.44 µM 0.752394125798409 0.185938967910997 no 601 0.225907039058904 1012 2989575
SGTC_2210 7115885 190.385 µM 0.750516547274021 0.186508450927675 no 602 0.226471830791389 1123 2927039
SGTC_2207 7258803 200 µM 0.750032438357325 0.186655459610603 no 603 0.226617584092067 1075 3666799
SGTC_2292 7671323 168.05 µM 0.744068931266568 0.188472269904273 no 604 0.22841738705736 1109 937504
SGTC_188 3229-0966 278.469 µM 0.743792936893931 0.188556616081141 no 605 0.228500876928814 1230 5722370
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.743713087683345 0.188581023004588 no 606 0.228525034967352 1105 6708760
SGTC_1243 0416-0003 5.65 µM 0.743477922321666 0.188652915593807 no 607 0.228596191580134 1114 2141977
SGTC_3282 9108498 15.4605 µM 0.742180127301163 0.189049969369879 no 608 0.228989103679295 1093 16459645
SGTC_659 k018-0002 107 µM 0.742067608257802 0.189084418228956 no 609 0.229023187064584 1124 6797879 YHR007C ERG11
SGTC_3164 9100705 49.47 µM 0.741262422044746 0.189331047052539 no 610 0.229267170791116 1108 17174235
SGTC_142 0335-0849 62.6745 µM 0.740928797448091 0.189433294380552 no 611 0.229368306828165 1145 3889043 YPR107C YTH1
SGTC_3024 9090631 49.47 µM 0.740753639055178 0.189486989508798 no 612 0.229421414918543 1092 25236383
SGTC_976 1348-1067 47.6 µM 0.738303474790499 0.190239073360494 no 613 0.230165027710401 1196 5310671 YGL099W LSG1
SGTC_1733 st037357 54.9 µM 0.738106057830773 0.190299750703235 no 614 0.230225001424411 1136 1272339 YGL099W LSG1
SGTC_4 0960-0234 25.671 µM 0.737802869052498 0.1903929608243 no 615 0.230317124799488 1119 6821112
SGTC_2358 9037157 4 µM 0.737456667583529 0.19049942873072 no 616 0.230422342707368 1122 2388925
SGTC_3200 9114385 49.47 µM 0.736735339176734 0.190721377441914 no 617 0.230641655879773 1127 17018030 YLR208W SEC13
SGTC_216 k038-0035 28.382 µM 0.735960840054312 0.190959863081086 no 618 0.230877264897724 1077 4444231 YPR107C YTH1
SGTC_2971 9092186 9.93 µM 0.735644602247127 0.19105729235949 no 619 0.23097350567303 1101 25236400
SGTC_2879 9041815 71.43 µM 0.734634172016937 0.191368798699318 no 620 0.231281160350707 1085 4942971
SGTC_2451 5856223 45.7 µM 0.73384982341168 0.191610820608675 no 621 0.231520135452633 1122 2179896
SGTC_1884 5633444 25 µM 0.733628069327218 0.191679279964079 no 622 0.231587724374058 1118 5724239
SGTC_1626 st003712 1.76 µM 0.733591008317353 0.191690722805299 no 623 0.231599021354348 1093 24207035
SGTC_3111 9122088 49.47 µM 0.730607706636571 0.192613209461591 no 624 0.232509401698555 1061 16876704
SGTC_2411 st077133 39.94 µM 0.730586552944768 0.192619760208609 no 625 0.232515864027867 1181 1403142 YNL221C POP1
SGTC_2689 tacrolimus 100 µM 0.73025409785709 0.192722730769521 no 626 0.232617440233896 1135 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1977 st070720 65.3 µM 0.729884433520627 0.192837265550677 no 627 0.23273041407451 1109 682188
SGTC_1590 st077108 57.8 µM 0.728266155340769 0.193339153304758 no 628 0.233225337984848 1129 5489485
SGTC_2084 5306078 60.6385 µM 0.727319201392265 0.193633207979326 no 629 0.233515219079674 1102 679340
SGTC_937 3122-0005 46.7 µM 0.726917419983559 0.193758054277571 no 630 0.233638272568094 1154 759535
SGTC_109 0132-0036 33.701 µM 0.726567289450104 0.193866891007924 no 631 0.233745536266852 1039 67274 A color developer.
SGTC_130 0136-0219 337.655 µM 0.724308591272464 0.194569893793871 no 632 0.234438151871424 1108 234244
SGTC_817 1391-0715 46 µM 0.722798277193678 0.195040832002222 no 633 0.23490191296857 1113 1353946
SGTC_619 1652-1634 108 µM 0.721788720938036 0.19535601259867 no 634 0.235212192516774 1110 5400454
SGTC_1091 telmisartan 47.6 µM 0.721082369189531 0.19557671747622 no 635 0.235429418927008 1225 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1324 1418-0026 34.4 µM 0.720839994319602 0.19565248418937 no 636 0.235503982681897 1154 1372513
SGTC_1647 st011722 22.4 µM 0.719783160045769 0.195983060214496 no 637 0.235829257443241 1138 2854783
SGTC_1379 2144-0755 36.5 µM 0.719126500405074 0.196188632845532 no 638 0.236031490274842 1198 5392327
SGTC_676 falcarinol 140 µM 0.714541576078839 0.197627621108416 no 639 0.237446178431361 1200 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_546 peri-Naphthalide 147 µM 0.712425924800436 0.198293768292949 no 640 0.23810053330288 1126 223824 A penicillin ester.
SGTC_1878 temozolomide 1 mM 0.711411966731045 0.198613509284125 no 641 0.238414492799084 1140 5394 DNA alkylating agent.
SGTC_2928 9011484 9.79 µM 0.710348660637732 0.19894914545455 no 642 0.238743975655173 1154 2994751
SGTC_2693 st077581 40.7 µM 0.710300653348173 0.198964307178652 no 643 0.238758857377534 1196 25238761
SGTC_3259 9138485 49.47 µM 0.709706623856603 0.199151971948163 no 644 0.238943041853722 1285 17646153
SGTC_2204 7233102 200 µM 0.709629255703863 0.199176421806779 no 645 0.238967036300202 1110 2172480
SGTC_80 0159-0065 512.242 µM 0.708498928900995 0.199533833450045 no 646 0.239317738550179 1117 1548079
SGTC_1224 0823-0416 294 µM 0.708380832096672 0.199571198160015 no 647 0.239354396217054 1186 3598164
SGTC_2401 5128683 200 µM 0.708090075353291 0.199663208782949 no 648 0.239444661210905 1137 708373
SGTC_687 k029-0044 34.9 µM 0.707179933356683 0.199951390212304 no 649 0.239727333553664 1199 5829338
SGTC_1103 duloxetine 36.1 µM 0.705842966157612 0.200375172056155 no 650 0.240142899475661 1246 60835 A selective serotonin reuptake inhibitor.
SGTC_2650 prasterone 100 µM 0.705278361763293 0.200554298047192 no 651 0.240318511794875 1136 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2183 6420625 130.508 µM 0.7041147360788 0.2009237722788 no 652 0.240680661915978 1211 2897619
SGTC_1988 st071872 53.4 µM 0.701276394247212 0.201826713468911 no 653 0.241565271205487 1200 16414116
SGTC_1698 5-fluorocytosine 1.055 µM 0.699876224687219 0.20227303277422 no 654 0.242002303225634 1207 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_561 1550-0330 72.9 µM 0.699811654881906 0.202293629333875 no 655 0.242022467603752 1157 6812934
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.699432425924003 0.202414621592119 no 656 0.24214091466228 1178 75037 A free radical scavenger.
SGTC_2045 5106652 78.05 µM 0.697199924528553 0.20312777356155 no 657 0.242838843089647 1177 673349
SGTC_2914 7968218 45.32 µM 0.696942756055378 0.203210019895069 no 658 0.242919309404387 1121 2977111
SGTC_1006 4099-6547 255 µM 0.696609199769032 0.203316725801782 no 659 0.243023698446411 1194 3146833
SGTC_1837 st055472 66.5 µM 0.696215929408481 0.203442577406108 no 660 0.243146806634791 1248 676091
SGTC_699 0375-0592 111 µM 0.695412803275763 0.203699732478416 no 661 0.243398319568677 1225 762578
SGTC_2412 st077135 33.4 µM 0.693944132267439 0.204170491061105 no 662 0.243858622826487 1247 13258915
SGTC_2327 6189656 200 µM 0.692471005746729 0.204643328085395 no 663 0.244320794014352 1221 5349088
SGTC_2235 salicylic acid 500 µM 0.691828889789861 0.204849635067283 no 664 0.244522395839264 1211 338 A COX inhibitor and kinase inhibitor.
SGTC_2257 7960413 200 µM 0.691270531821342 0.205029131735327 no 665 0.244697773416888 1187 2974689 YIL048W NEO1
SGTC_694 1315-0438 43.2 µM 0.690523421951407 0.205269453108744 no 666 0.244932542966768 1138 6793154
SGTC_2717 st081029 62.2815 µM 0.690518476889962 0.205271044334292 no 667 0.244934097291611 1182 5292846
SGTC_2890 9046729 58.44 µM 0.690516713972556 0.205271611608938 no 668 0.244934651410644 1133 903329
SGTC_2596 sinensetin 100 µM 0.688392555672334 0.205955803384432 no 669 0.245602805239871 1189 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_133 0724-0033 378.92 µM 0.687362068221262 0.206288210278987 no 670 0.245927297300083 1117 280309
SGTC_3308 9128332 17.569 µM 0.686391316504737 0.206601638742338 no 671 0.24623318938854 1213 17332805 YDL196W YDL196W
SGTC_1189 1431-2119 7.28 µM 0.684777511360488 0.207123314824947 no 672 0.246742164199513 1240 3107275
SGTC_584 0986-0246 15.4 µM 0.683448850071459 0.207553400042944 no 673 0.247161630491712 1309 53315 YDR232W HEM1
SGTC_2215 7188065 200 µM 0.682839085441804 0.207750956284711 no 674 0.247354264420903 1225 940217
SGTC_1360 1598-0022 39.8 µM 0.68259431561794 0.207830289929739 no 675 0.247431613501709 1232 761525
SGTC_1081 sertraline 6 µM 0.681260591432505 0.208262884593205 no 676 0.247853307255539 1221 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3242 9133940 49.47 µM 0.680872998497014 0.208388700273293 no 677 0.247975927376328 1262 17248444
SGTC_1828 st055811 49 µM 0.680604364040116 0.208475927403621 no 678 0.248060932407778 1181 5877589
SGTC_1254 0550-0035 264 µM 0.680525340097975 0.208501591023243 no 679 0.248085941215691 1254 15121435
SGTC_3025 9087895 49.47 µM 0.679223095705163 0.208924772910412 no 680 0.248498257800316 1232 17173641
SGTC_98 0074-0023 107.663 µM 0.677418246971615 0.209512118661322 no 681 0.249070312142144 1202 3563821
SGTC_3142 9086498 49.47 µM 0.677077410703718 0.209623144780274 no 682 0.2491784202108 1170 25236367
SGTC_1529 apigenin 74 µM 0.675634967343567 0.210093398165008 no 683 0.249636217417119 1282 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_730 1436-0052 41.2 µM 0.674815112816676 0.210360956322534 no 684 0.249896618727491 1249 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.674490759476595 0.21046686369797 no 685 0.249999679274407 1098 6708630 An antioxidant.
SGTC_2269 7935389 174.42 µM 0.673959597731126 0.21064036542383 no 686 0.25016850014997 1201 97605
SGTC_1562 morin hydrate 59.1 µM 0.673432843649447 0.210812510253766 no 687 0.250335979818678 1253 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2123 5259487 200 µM 0.670475507414111 0.21178050752367 no 688 0.251277357369005 1211 2173474
SGTC_2870 9038528 12.99 µM 0.66989920609047 0.211969445208694 no 689 0.25146102294237 1227 6463316
SGTC_1513 0337-0559 19 µM 0.669817431792127 0.211996262513591 no 690 0.251487089922284 1170 775073
SGTC_3236 9132701 49.47 µM 0.66894678130201 0.212281909215355 no 691 0.251764713419483 1206 24282524
SGTC_900 1112-0045 141 µM 0.668384468873635 0.212466514557736 no 692 0.251944103421548 1163 56211 YIL048W NEO1
SGTC_1312 1218-2183 165 µM 0.667811125146411 0.212654837969569 no 693 0.252127082081889 1258 6744073
SGTC_1930 st074634 34.3 µM 0.667572226054537 0.212733336747223 no 694 0.252203345748349 1213 684253 YOR116C RPO31
SGTC_801 0866-0028 10.1 µM 0.666944405680601 0.212939710050197 no 695 0.252403822587462 1268 6849771
SGTC_87 0100-0052 35.5 µM 0.666546835220595 0.213070457393449 no 696 0.252530818992365 1304 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_327 1273-0057 3.96 µM 0.665387817054992 0.213451886049566 no 697 0.252901237590565 1179 3108138
SGTC_1950 st077106 7.18 µM 0.664782297492588 0.213651318501939 no 698 0.253094873426735 1225 13831864
SGTC_1497 4476-2978 41.3 µM 0.664322745429973 0.213802747881678 no 699 0.253241883141748 1262 1528379
SGTC_2921 7974240 10.71 µM 0.664143340599842 0.213861881455486 no 700 0.253299286543837 1257 2979074 YDR527W RBA50
SGTC_2298 7976326 193.81 µM 0.66363206254367 0.214030455900162 no 701 0.253462915533026 1139 2235818
SGTC_511 blebbistatin 171 µM 0.663459641079878 0.21408732273791 no 702 0.253518109671899 1298 3476986 A myosin inhibitor.
SGTC_2286 7945697 125 µM 0.662862586606944 0.214284306985511 no 703 0.253709282615204 1212 1245733
SGTC_1701 st028638 40.4 µM 0.661385210730879 0.214772185786154 no 704 0.254182653940515 1237 3490878
SGTC_196 k015-0023 18.111 µM 0.658949187726371 0.215578049709283 no 705 0.254964199178413 1248 5211998
SGTC_1703 st026983 48.3 µM 0.657963971042368 0.215904467857053 no 706 0.255280641349516 1271 1104023
SGTC_81 0411-0046 9.971 µM 0.656984727725349 0.216229190544148 no 707 0.255595368266305 1153 12925265
SGTC_1935 st074532 41.6 µM 0.656932999719262 0.216246351706585 no 708 0.25561199918161 1316 2829742
SGTC_1094 duloxetine 25.4 µM 0.656376643982639 0.216430976830521 no 709 0.255790907159859 1249 60834 A selective serotonin reuptake inhibitor.
SGTC_3157 9099274 49.47 µM 0.655141641145833 0.21684113497229 no 710 0.256188281973443 1236 17217662
SGTC_288 1315-0019 35.1 µM 0.653753953059237 0.217302537297991 no 711 0.256635168566536 1291 6811474
SGTC_2052 5265182 7.135 µM 0.653369943915818 0.217430319330114 no 712 0.256758905303086 1270 1239884
SGTC_1355 1499-0035 1.68 µM 0.653114388859232 0.217515381300483 no 713 0.256841268333265 1267 1548538
SGTC_1088 bifonazole 369 nM 0.6525950913305 0.217688289597594 no 714 0.257008675471094 1214 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2255 7941087 197.44 µM 0.652435250925843 0.217741526937013 no 715 0.257060215011525 1292 935561
SGTC_1208 2323-2347 50.3 µM 0.652181045136024 0.217826209608967 no 716 0.257142193152675 1260 5412760
SGTC_2463 5473429 200 µM 0.652128666475715 0.217843660686021 no 717 0.25715908629485 1243 5399405
SGTC_3106 9121286 49.47 µM 0.651643716873199 0.218005270363495 no 718 0.257315519424317 1286 15943471
SGTC_589 1227-0070 34.1 µM 0.650087910964822 0.218524209743065 no 719 0.257817718805349 1267 2841384
SGTC_285 1486-1325 46 µM 0.649173801699183 0.218829442510113 no 720 0.258113021653275 1287 22310230
SGTC_620 0109-0052 432 µM 0.648893817193213 0.218922981967497 no 721 0.258203505675745 1271 493037
SGTC_1862 st057513 3.81 µM 0.648557841035538 0.21903525791688 no 722 0.258312106506977 1239 5393163
SGTC_2641 levomentholum 100 µM 0.648333595112796 0.219110214467117 no 723 0.258384604861107 1223 16666
SGTC_3073 9114972 49.47 µM 0.648285781041888 0.219126198728978 no 724 0.258400064438505 1213 41905075
SGTC_1096 rimcazole 32.2 µM 0.646898678821555 0.2195901992863 no 725 0.258848760479014 1211 18528119 A dopamine reuptake inhibitor.
SGTC_2526 patulin 37.61 µM 0.644554926914115 0.220375490258216 no 726 0.259607825989265 1319 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_852 0418-0143 439 µM 0.643942559880156 0.220580933181509 no 727 0.259806341069343 1302 5369229
SGTC_610 4215-0184 155 µM 0.643940343404094 0.220581676985974 no 728 0.259807059741314 1312 5605015
SGTC_2741 miltefosine 3.04 µM 0.643430633829999 0.220752763351182 no 729 0.259972355617537 1214 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1170 0310-0127 64.8 µM 0.643216144939793 0.220824780246488 no 730 0.260041929338044 1282 774975
SGTC_440 fluspirilene 35.1 µM 0.643036552680437 0.220885090578132 no 731 0.260100191028762 1345 3396 An atypical antipsychotic.
SGTC_2229 7354935 190 µM 0.642145385569191 0.221184500086064 no 732 0.260389394888126 1233 318112
SGTC_1811 st050069 61.5 µM 0.641769744771358 0.221310775377916 no 733 0.260511348417752 1267 3877702
SGTC_320 4092-0846 5.34 µM 0.638357709855075 0.222459650420847 no 734 0.261620426657708 1269 1359356
SGTC_2277 7947813 106.88 µM 0.638279059460648 0.222486173040727 no 735 0.261646020426902 1358 1246798
SGTC_786 4544-0069 423 µM 0.637496225093266 0.222750260056845 no 736 0.261900834019207 1335 748821 YLR208W SEC13
SGTC_334 1502-1024 68.5 µM 0.637470897169124 0.222758807344595 no 737 0.26190908041581 1302 3296216
SGTC_1251 0490-5699 265 µM 0.636984832293702 0.222922873431577 no 738 0.262067361725131 1322 3883818
SGTC_2056 5235370 200 µM 0.636529979600116 0.223076466502371 no 739 0.262215523548982 1275 5511916
SGTC_2491 paeonol 100 µM 0.635722193268574 0.223349385455462 no 740 0.262478754249005 1236 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1672 st016598 6.51 µM 0.63566852254068 0.223367525394096 no 741 0.262496248545639 1261 4665860 YNL267W PIK1
SGTC_2657 nystatin 74.44 µM 0.635643466449602 0.22337599428166 no 742 0.262504415933626 1296 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1405 3909-7894 12 µM 0.635049662148976 0.223576751913183 no 743 0.26269801292504 1316 7104060
SGTC_2348 9022543 33.42 µM 0.634674320078224 0.223703703175219 no 744 0.262820422719658 1293 3162678 YDL140C RPO21
SGTC_1487 3970-0795 2.82 µM 0.631656320490819 0.224725964097255 no 745 0.263805737910451 1323 3765103
SGTC_2140 5586273 200 µM 0.629383579226708 0.225497535645594 no 746 0.264548982825831 1292 854421
SGTC_2764 methyldopa 94.69 µM 0.629217905518604 0.225553838687559 no 747 0.264603204026819 1331 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2746 daunorubicin 9.88 µM 0.627105171249402 0.226272533813975 no 748 0.265295148799931 1213 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2831 7999036 19.48 µM 0.624524040437575 0.227152317899073 no 749 0.266141743627592 1366 2988270
SGTC_2749 bexarotene 57.39 µM 0.622114728476599 0.227975274234226 no 750 0.266933215454186 1288 82146 An retinoic acid receptor inhibitor.
SGTC_2057 5236571 38.335 µM 0.621293744214872 0.22825608308585 no 751 0.267203184500852 1324 54684039 YBR257W POP4
SGTC_1792 st045773 43.6 µM 0.621099272330418 0.228322628577292 no 752 0.267267154007716 1264 2919270
SGTC_85 0868-0259 160.055 µM 0.620976137007799 0.228364769356825 no 753 0.267307662088737 1293 83173
SGTC_571 k831-0106 44.2 µM 0.62087484464741 0.22839943806417 no 754 0.267340986767506 1329 4783639
SGTC_1642 st009582 77.7 µM 0.620423535930516 0.228553940635215 no 755 0.267489490541882 1332 6739311
SGTC_43 0570-0105 72.5 µM 0.618679729223891 0.229151472710163 no 756 0.268063683234254 1352 1114046 YDL195W SEC31
SGTC_2462 5162487 171.77 µM 0.618626324194459 0.229169786271886 no 757 0.268081277985074 1281 2259986
SGTC_569 4130-2812 160 µM 0.617697732053759 0.229488348693293 no 758 0.268387303631422 1254 743552
SGTC_1097 itavastatin 7.23 µM 0.617691451993488 0.229490503972519 no 759 0.268389373878042 1330 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3150 9097574 49.47 µM 0.617542003179461 0.229541797260702 no 760 0.268438642638014 1308 17217476
SGTC_194 1486-1323 56.904 µM 0.617270395191691 0.229635034027422 no 761 0.268528195229118 1284 5178754
SGTC_1610 st001799 48.1 µM 0.617252187727069 0.229641284989316 no 762 0.268534198997705 1264 621897
SGTC_3194 9111903 49.47 µM 0.61691310349116 0.229757716341378 no 763 0.26864602169176 1358 17087251
SGTC_1778 st046819 58.9 µM 0.616752451440276 0.229812890974235 no 764 0.2686990094537 1340 671715
SGTC_2988 9073640 71.4286 µM 0.616098850530376 0.230037441332508 no 765 0.268914640342943 1352 9102229
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.616060299203404 0.230050689814368 no 766 0.268927361607489 1332 551469
SGTC_1730 st033808 45.1 µM 0.615969112778082 0.230082028481685 no 767 0.268957452737624 1360 1045166
SGTC_844 0330-0132 15.3 µM 0.615846665849436 0.230124114418778 no 768 0.268997862358735 1318 2828079
SGTC_446 go6976 132 µM 0.614870333489423 0.230459841285797 no 769 0.269320178046419 1289 3501 A protein kinase C inhibitor.
SGTC_31 0508-1974 57.237 µM 0.614768823375796 0.230494762802249 no 770 0.269353700596351 1273 6810525
SGTC_1719 st032227 49.2 µM 0.613991553441286 0.230762257267944 no 771 0.269610454393829 1321 3125804
SGTC_2929 9013348 24.6 µM 0.613218202832661 0.23102857491064 no 772 0.269866035165765 1326 2995952
SGTC_442 cape 100 µM 0.61304245092727 0.231089122258304 no 773 0.269924135443215 1351 5281787
SGTC_654 1124-0271 80.9 µM 0.611344205618498 0.231674631653043 no 774 0.270485865765842 1309 5403748
SGTC_151 3013-0144 2.285 µM 0.611173472902508 0.231733541409173 no 775 0.270542371495959 1372 906558 YHR107C CDC12
SGTC_3003 9075612 71.4286 µM 0.610853318129586 0.231844030369912 no 776 0.270648345871384 1327 6501993
SGTC_2525 harmine 47.85 µM 0.61017960903714 0.232076630660888 no 777 0.270871417892271 1319 5280953 A monoamine oxidase inhibitor
SGTC_2309 7664088 163.95 µM 0.608889239818082 0.232522497369856 no 778 0.271298928451765 1336 704922
SGTC_2013 4024628 200 µM 0.606420061177779 0.233377009311859 no 779 0.272117925155789 1354 5230760
SGTC_1524 corynanthine 62.1 µM 0.604859179813494 0.23391808315589 no 780 0.272636283944799 1378 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_159 3970-0959 50 µM 0.603364394647566 0.234436895835478 no 781 0.27313315157635 1399 6615653
SGTC_697 0508-1955 564 µM 0.603092797427789 0.234531230582802 no 782 0.273223478832465 1331 6243113
SGTC_2766 oltipraz 83.91 µM 0.602847332075719 0.234616506924801 no 783 0.27330512793444 1386 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_570 0987-0065 62.6 µM 0.601668118383615 0.235026412797052 no 784 0.27369753800006 1252 3104428
SGTC_2985 9022375 71.43 µM 0.600368461171457 0.23547864393619 no 785 0.274130350996246 1350 4939335
SGTC_3319 9138450 16.7555 µM 0.600015380801368 0.23560158532967 no 786 0.274247992512295 1314 2029690
SGTC_2645 abamectin 100 µM 0.599165179918202 0.235897767635863 no 787 0.27453136998935 1314 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3324 9138759 60.749 µM 0.598526958000841 0.236120238161714 no 788 0.274744188386069 1351 45595710
SGTC_161 4065-0411 162.148 µM 0.598149555680187 0.23625184690955 no 789 0.274870073400971 1365 1906281 YLR208W SEC13
SGTC_352 k048-0007 5.11 µM 0.596637844508192 0.236779419640729 no 790 0.275374599365221 1311 6811911
SGTC_876 0720-0963 56.8 µM 0.595635939171532 0.237129431695156 no 791 0.275709231105934 1457 765861
SGTC_294 k038-0071 157 µM 0.591929789786578 0.238426629066879 no 792 0.276948802273492 1343 24152826
SGTC_1085 doxorubicin 7.67 µM 0.591194899532141 0.238684310438897 no 793 0.277194919910963 1383 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1946 st076057 65.1 µM 0.589719065681638 0.239202255708597 no 794 0.277689505448998 1262 953009
SGTC_353 1988-1175 58.3 µM 0.58952274613872 0.239271200488437 no 795 0.277755329067131 1278 2788357
SGTC_1402 3909-7673 35.9 µM 0.589006416579175 0.239452580291062 no 796 0.277928484618093 1337 5328014
SGTC_725 1497-0963 19 µM 0.589006153601051 0.239452672690954 no 797 0.277928572823486 1407 3549977
SGTC_3330 9141424 71.43 µM 0.588996152593687 0.239456186655499 no 798 0.277931927267748 1387 27261020
SGTC_3132 9126706 49.47 µM 0.587874777604658 0.239850372697679 no 799 0.278308173636307 1363 850858
SGTC_3345 9148410 3.559 µM 0.587464977056872 0.23999451416369 no 800 0.27844573279813 1347 4903596
SGTC_3323 9138564 53.9225 µM 0.586672055976696 0.240273546849114 no 801 0.278711989376492 1399 43912313 YNL103W MET4
SGTC_1370 2001-0092 44.6 µM 0.585823857569483 0.240572227467202 no 802 0.278996944781083 1503 790957
SGTC_1649 st011737 51.3 µM 0.585517662601213 0.240680099168006 no 803 0.279099846916491 1349 1761035
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.584760065255621 0.240947111884118 no 804 0.27935452994441 1341 77254
SGTC_2365 9042475 200 µM 0.584573924371774 0.241012741280073 no 805 0.27941712257478 1360 6464479
SGTC_1009 4106-0057 9.87 µM 0.58383875830195 0.241272040503614 no 806 0.279664399619441 1364 2928005
SGTC_257 daunorubicin 18.5 µM 0.583579809940914 0.241363409848053 no 807 0.279751523573535 1457 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1760 st045453 10.4495 µM 0.583223754543683 0.241489073880114 no 808 0.27987134098016 1384 3323419 YIL048W NEO1
SGTC_2340 7987427 183.45 µM 0.581572910150841 0.242072176923416 no 809 0.280427197204908 1385 2239331
SGTC_1120 ficusin 1.78878 µM 0.580628466438918 0.242406111661857 no 810 0.280745441250285 1478 6199 A DNA cross-linker.
SGTC_941 3237-0776 460 µM 0.579577598963609 0.242777968677582 no 811 0.281099751500029 1423 760008
SGTC_2126 5251174 33.877 µM 0.577769957092449 0.243418337407593 no 812 0.281709720506474 1469 790722
SGTC_356 1634-0012 32.5 µM 0.577284349319175 0.24359052246094 no 813 0.281873692214529 1386 735457
SGTC_1018 4259-0013 28.1 µM 0.576071081736017 0.24402100582287 no 814 0.282283568476 1388 6801262
SGTC_2541 muurolladie-3-one 83.07 µM 0.575724033397561 0.244144218595653 no 815 0.282400863993293 1384 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2375 9072683 200 µM 0.574978301964868 0.244409089513837 no 816 0.282652985841128 1448 16798029
SGTC_627 1391-0720 175 µM 0.573951191721123 0.244774154681985 no 817 0.283000415114439 1357 997839
SGTC_2351 9026858 72.31 µM 0.573322253569402 0.24499784260754 no 818 0.283213260249297 1315 1409300
SGTC_351 caspofungin 25 nM 0.57331215810271 0.245001434054326 no 819 0.283216677381418 1454 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1941 st076221 61.8 µM 0.570697762488892 0.245932453984421 no 820 0.284102267890892 1367 2828568
SGTC_588 3970-1144 52.9 µM 0.570561856038601 0.245980903878754 no 821 0.284148340520701 1365 1888707
SGTC_1005 4092-0690 4.4 µM 0.569724447400912 0.246279548367774 no 822 0.284432302970036 1358 1529343
SGTC_1317 1273-0028 910 nM 0.568441977304397 0.246737291377243 no 823 0.284867446891097 1373 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_671 0560-0003 407 µM 0.568347381039126 0.246771072985802 no 824 0.284899556110799 1382 3238678
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.567349886794483 0.247127442378553 no 825 0.285238244941445 1587 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2430 5571206 200 µM 0.567305562544868 0.247143284249417 no 826 0.285253299231677 1421 1731771
SGTC_2347 9049783 174.81 µM 0.56296885921882 0.248695882484327 no 827 0.286728044620373 1443 6467988 YPL169C MEX67
SGTC_2782 7736369 71.43 µM 0.561951045110146 0.249061024818477 no 828 0.287074686921013 1415 2950836 YOL077C BRX1
SGTC_517 1365-0151 113 µM 0.561592377592768 0.24918976525778 no 829 0.287196887472439 1419 768657
SGTC_700 3453-2283 142 µM 0.56096334886657 0.249415634826112 no 830 0.287411261431221 1457 565664
SGTC_934 2950-0684 338 µM 0.560923251152031 0.249430036670083 no 831 0.28742492935985 1481 1121253
SGTC_1676 st018489 23.4 µM 0.56089231702926 0.24944114754072 no 832 0.287435473946 1416 3696235
SGTC_182 3448-4371 550.524 µM 0.560698329908604 0.249510829532647 no 833 0.287501602956379 1454 3491403
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.559706996261837 0.249867087297068 no 834 0.287839654737171 1410 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1258 0671-0043 57.1 µM 0.559156874211708 0.250064902308992 no 835 0.288027331207146 1370 4298767
SGTC_2531 methyl deoxycholate 70.07 µM 0.558737098147955 0.25021590287725 no 836 0.288170578431993 1366 16667744 Haematoxylin.
SGTC_2709 st078560 56 µM 0.557390369314463 0.250700670301899 no 837 0.288630372032396 1495 17250903
SGTC_874 0599-0792 117 µM 0.557196832133393 0.250770376642486 no 838 0.288696476942778 1430 765305
SGTC_3339 9145883 14.936 µM 0.554718334498977 0.251663964305126 no 839 0.289543666726844 1388 2030670
SGTC_1552 6-methylflavone 10.6 µM 0.55459964332177 0.251706798906616 no 840 0.289584266526814 1381 689013
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.552306079632994 0.252535281342917 no 841 0.290369332975897 1405 756377
SGTC_245 methotrexate 289.6 µM 0.551949986188079 0.252664038354711 no 842 0.290491309910092 1429 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2324 6149169 200 µM 0.550221622869377 0.253289474418752 no 843 0.29108368721977 1361 2888231
SGTC_2030 5175110 200 µM 0.549926534365042 0.253396338229382 no 844 0.291184881885402 1461 2831986
SGTC_2533 agelasine 13.65 µM 0.549480054512781 0.253558072178932 no 845 0.291338024388486 1521 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2522 biochanin a 4.94 µM 0.549115344651682 0.25369022579911 no 846 0.291463147684332 1440 5280373 A possible chelator.
SGTC_598 3937-0236 20.2 µM 0.548493901629116 0.253915490685338 no 847 0.291676407758809 1448 1379313
SGTC_2185 6113692 200 µM 0.547848661577951 0.25414949271522 no 848 0.291897911171728 1403 874150
SGTC_2032 5185112 25.99 µM 0.54576394125891 0.254906307376948 no 849 0.29261410637488 1369 5718189
SGTC_3100 9120536 49.47 µM 0.545043632959107 0.255168074321287 no 850 0.292861754309886 1372 16421196
SGTC_1217 1183-1422 255 µM 0.544514023543293 0.255360629099807 no 851 0.293043900436114 1500 2849664
SGTC_2610 ononetin 44.17 µM 0.544230352924628 0.255463796959236 no 852 0.293141483572584 1395 259632
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.543231244234796 0.255827335072603 no 853 0.293485298468127 1465 65057 A dermal irritant. YDR527W RBA50
SGTC_2493 resveratrol 26.09 µM 0.54207637362201 0.25624788530602 no 854 0.293882946965463 1377 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2948 9070189 9.45 µM 0.540984179715027 0.256645942944348 no 855 0.294259243550493 1430 6473636 YDL196W YDL196W
SGTC_3004 9076122 71.4286 µM 0.540959315688328 0.256655008558274 no 856 0.294267812612697 1475 44782551
SGTC_1252 0493-0875 34.8 µM 0.540789477533566 0.256716937305214 no 857 0.294326348197835 1410 3960963
SGTC_330 1488-0319 80.1 µM 0.540498622638077 0.256823010923773 no 858 0.294426605306368 1435 6846614
SGTC_540 1187-0821 17.3 µM 0.539985206717477 0.257010307316692 no 859 0.294603617226186 1406 847520
SGTC_456 gingerol 170 µM 0.539795953584397 0.257079365613147 no 860 0.29466887896883 1470 442793 A herb.
SGTC_1765 st044815 90.4 µM 0.538440569434167 0.257574225963097 no 861 0.295136462197157 1359 645695
SGTC_458 nppb 133 µM 0.53838045458248 0.257596185772827 no 862 0.295157208653516 1534 4549 A chloride channel blocker.
SGTC_605 1315-0399 119 µM 0.537264330209971 0.258004079834042 no 863 0.295542520327136 1481 24020461
SGTC_2193 5925765 200 µM 0.535540576829817 0.258634693010361 no 864 0.296138053428198 1449 877370
SGTC_913 3487-1245 167 µM 0.534839317782218 0.258891467856991 no 865 0.296380486255498 1367 4016153
SGTC_1201 1889-3372 45.9 µM 0.533352176374999 0.259436439533236 no 866 0.296894907928689 1412 5392199
SGTC_1895 st058434 18.3 µM 0.533019143964356 0.259558562366664 no 867 0.297010164166419 1480 5393175
SGTC_3060 1327-0027 12.5 µM 0.532258939246159 0.259837440260623 no 868 0.297273333331406 1401 16000455 YPR107C YTH1
SGTC_2969 9091408 28.7 µM 0.531564247085464 0.260092420263204 no 869 0.297513916367431 1389 4286311
SGTC_2053 5265679 138 µM 0.531505696693015 0.260113916508129 no 870 0.297534197368631 1387 764595
SGTC_467 ro 31-8220 72.8 µM 0.531201857253885 0.260225483105814 no 871 0.297639453049595 1426 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2290 7904846 200 µM 0.530436296929268 0.260506697988156 no 872 0.297904732823365 1424 2962154
SGTC_905 2-aminofluorene 215 µM 0.529813236998552 0.260735683348515 no 873 0.298120713303105 1449 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.529280421462606 0.260931584448079 no 874 0.298305467599357 1363 88881 An O-methylated flavonoid and antioxidant.
SGTC_1382 3002-2117 298 µM 0.527704719463968 0.26151136781058 no 875 0.298852148548944 1533 1497314
SGTC_1334 1486-0610 236 µM 0.527603975756432 0.261548459183864 no 876 0.298887116489369 1471 3742339
SGTC_851 0394-0702 453 µM 0.526743480209876 0.261865382642986 no 877 0.299185868494514 1482 762646
SGTC_380 3970-0968 6 µM 0.525780947472721 0.262220119968915 no 878 0.299520206862592 1394 2891601
SGTC_534 k292-0788 63.4 µM 0.525596192456299 0.26228823879308 no 879 0.299584401388537 1501 4146317
SGTC_565 1418-0001 44.5 µM 0.525214821690722 0.262428878131078 no 880 0.299716931255214 1492 2862145
SGTC_1441 4106-0040 13 µM 0.52275009055569 0.263338735237365 no 881 0.300574087727641 1434 2904180
SGTC_632 0781-2353 4.65 µM 0.522435866699075 0.263454846839046 no 882 0.300683444470051 1475 6811515 YHR007C ERG11
SGTC_1084 voriconazole 435 nM 0.52202816209445 0.263605540269551 no 883 0.300825361306502 1459 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1026 k007-1105 30.6 µM 0.519766230972686 0.264442380299216 no 884 0.301613259253704 1441 7066794
SGTC_2456 5770359 74.46 µM 0.519414883986518 0.264572488328726 no 885 0.30173572710891 1533 3118787
SGTC_354 2783-3500 4.88 µM 0.518491031423284 0.264914757414312 no 886 0.302057857965515 1393 6740761
SGTC_1525 8-methoxypsoralen 92.5 µM 0.518466223187908 0.264923951475958 no 887 0.302066510282053 1619 4114 Related to psoralen; DNA damaging agent.
SGTC_1799 st045822 46.1415 µM 0.518377210235301 0.264956941475967 no 888 0.302097556059977 1500 3674992
SGTC_919 tnp00227 403.569 nM 0.517491640796103 0.265285265071705 no 889 0.302406501372939 1478 1269246 A methoxyflavone. YNL221C POP1
SGTC_1268 0828-0275 2.46 µM 0.5170783435432 0.265438565091306 no 890 0.302550735325931 1494 745337
SGTC_1561 5-methoxyflavone 52.9 µM 0.516764059395589 0.265555169297347 no 891 0.302660435966322 1432 94525
SGTC_2884 9058502 51.95 µM 0.515485745325342 0.266029710898202 no 892 0.303106814050617 1435 6471554
SGTC_3207 9114163 49.47 µM 0.514461548257154 0.266410227710729 no 893 0.303464668644917 1628 849233
SGTC_2920 7982904 15.77 µM 0.514258994461949 0.26648551450575 no 894 0.303535463315793 1423 6456808
SGTC_1717 st033143 58.0435 µM 0.513795883510205 0.266657687664556 no 895 0.303697353141911 1565 674616
SGTC_2888 9058547 12.99 µM 0.513283201621839 0.266848355634181 no 896 0.303876616424925 1392 16476514
SGTC_1640 st009078 66.4 µM 0.513250401914656 0.266860556290112 no 897 0.303888086708452 1531 690618
SGTC_2420 aureobasidin a 50 nM 0.511990419168073 0.267329451052909 no 898 0.304328857450972 1617 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2710 st078562 53.7235 µM 0.511319566394889 0.26757927421551 no 899 0.304563653141972 1414 17250908
SGTC_2786 7743617 45.45 µM 0.511219996607189 0.267616363675187 no 900 0.304598509022248 1370 583674
SGTC_2788 5282734 71.43 µM 0.510407823259063 0.267918992660412 no 901 0.304882888581321 1597 743706
SGTC_3047 9092122 49.47 µM 0.51007062992783 0.268044686986232 no 902 0.305000990253033 1427 17173831
SGTC_258 haloperidol 50.781 µM 0.508113261438376 0.268774913927769 no 903 0.305686957777824 1411 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1710 st031758 61.5 µM 0.503750412399572 0.270406130714486 no 904 0.307218388878459 1556 5394341
SGTC_649 1123-0311 367 µM 0.503131409116693 0.270637968767574 no 905 0.307435942565221 1455 693629 YIL048W NEO1
SGTC_2965 9082772 38.63 µM 0.50239244679678 0.270914865543928 no 906 0.307695745552721 1555 16459634
SGTC_1970 st070122 35.8 µM 0.501007484774343 0.271434205516506 no 907 0.308182927653508 1522 102928
SGTC_2898 9056270 58.44 µM 0.500158559965031 0.271752784580796 no 908 0.308481717473104 1468 19154699
SGTC_3292 9120825 59.784 µM 0.499865583120126 0.271862774233296 no 909 0.308584863838886 1559 24824900
SGTC_1142 3253-1408 9.78 µM 0.49717477679481 0.272873994045032 no 910 0.309532903399549 1484 256655
SGTC_3168 9103419 49.47 µM 0.49705246841312 0.272920002493523 no 911 0.309576025949613 1472 16649256
SGTC_1210 3013-0140 750 nM 0.496594663524026 0.273092247992145 no 912 0.309737458549819 1607 905973
SGTC_1938 st074717 56.4 µM 0.496089258992855 0.273282465033826 no 913 0.309915718512251 1414 17250979
SGTC_1872 amphotericin b 148 nM 0.495580434340624 0.273474035563732 no 914 0.310095229931634 1540 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2226 7298446 200 µM 0.495453792048075 0.273521726230997 no 915 0.310139915892596 1540 3283010
SGTC_2125 5246583 200 µM 0.494099841131914 0.274031851104546 no 916 0.310617835035854 1606 835267
SGTC_1143 3454-2408 5.08 µM 0.493918103955197 0.274100359560723 no 917 0.310682009192981 1467 X1143
SGTC_2066 5222451 176 µM 0.493532779300232 0.274245641244248 no 918 0.310818092233963 1442 2281147
SGTC_1637 st007924 17.4 µM 0.493337371220472 0.274319331865582 no 919 0.310887113348629 1456 683336
SGTC_500 h-89 112 µM 0.492604278855416 0.274595876482067 no 920 0.311146112047041 1615 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2147 5545932 89.7195 µM 0.490702385599272 0.27531396871093 no 921 0.311818479484211 1492 797404
SGTC_1992 st073643 23.3 µM 0.490602002308921 0.2753518957964 no 922 0.31185398497808 1512 3161292
SGTC_1622 st003707 19.4 µM 0.490317485189131 0.275459406790925 no 923 0.311954627968937 1518 10140899
SGTC_377 3970-0964 33.1 µM 0.489719758873708 0.275685337946058 no 924 0.312166109001347 1535 16481235
SGTC_2819 7996655 46.38 µM 0.489210363209694 0.275877953371692 no 925 0.3123463867097 1537 6456960
SGTC_3251 9135047 49.47 µM 0.488563888165971 0.276122497145621 no 926 0.312575242195518 1578 17682963
SGTC_2104 5389443 200 µM 0.488551927810342 0.27612702242241 no 927 0.312579476904189 1580 2244536
SGTC_2859 9028643 45.46 µM 0.486434370061423 0.276928787206876 no 928 0.313329613439919 1495 17151580
SGTC_611 3453-1652 23.7 µM 0.48616519738004 0.27703078488113 no 929 0.313425022241747 1559 1560575
SGTC_843 0310-0051 143 µM 0.485685223650203 0.277212707067325 no 930 0.313595180881555 1521 2065037
SGTC_764 1951-2361 146 µM 0.483704429510818 0.27796409581538 no 931 0.314297824576348 1457 5438930
SGTC_1140 3229-1848 2.98 µM 0.483466920542241 0.27805425847245 no 932 0.314382120987995 1572 2849525
SGTC_1876 myriocin 605 nM 0.483218610989552 0.278148536478142 no 933 0.314470261080978 1602 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1490 4089-0339 670 nM 0.482807558750364 0.278304638776549 no 934 0.31461619164948 1549 742542
SGTC_2413 inermin 26.06 µM 0.482673796148159 0.278355446028609 no 935 0.314663685906021 1637 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1523 st012844 44.7 µM 0.482630028233283 0.278372071443653 no 936 0.314679226973648 1530 4274103
SGTC_3144 9087057 49.47 µM 0.48048852087203 0.279186122052832 no 937 0.315440031824384 1595 17249618
SGTC_2439 5492030 7.2 µM 0.476387350903414 0.280748321121426 no 938 0.316899222263757 1546 5722370
SGTC_1166 k206-0078 225 µM 0.475820698574741 0.280964499710049 no 939 0.317101061167697 1482 5404595
SGTC_358 0075-0058 9.45 µM 0.474420327106131 0.281499088015706 no 940 0.317600100276882 1720 1069125
SGTC_2102 5377816 72.7585 µM 0.473096946144704 0.282004735940537 no 941 0.318072007715948 1616 1379702
SGTC_52 0329-0193 875 nM 0.470192173198434 0.283116146102938 no 942 0.319108862749818 1600 3739292
SGTC_3007 9078383 71.4286 µM 0.469901762197691 0.283227377226161 no 943 0.319212602623545 1529 6496995
SGTC_2483 5729050 27.16 µM 0.469586955151472 0.283347976019423 no 944 0.319325073181663 1664 2865180
SGTC_222 nsc-310342 10.666 µM 0.468183593157473 0.28388588644836 no 945 0.319826652001737 1590 432556
SGTC_1313 1220-0047 237 µM 0.467851777157085 0.284013143351037 no 946 0.319945295334163 1582 3528706
SGTC_1797 st048695 56.8 µM 0.466779028220423 0.28442474688488 no 947 0.320328990853307 1607 592262 YIL048W NEO1
SGTC_2115 tiliquinol 12.7705 µM 0.465734730883737 0.284825707371295 no 948 0.320702694548854 1553 71208 A bioactive hydroxyquinoline.
SGTC_1171 0368-0077 21.4 µM 0.465535440969872 0.284902255849794 no 949 0.320774031473245 1495 3239779
SGTC_1689 st020265 53.493 µM 0.465193287225681 0.28503370208496 no 950 0.320896522729234 1615 5758320 YPR016C TIF6
SGTC_1044 1222-0021 1.78 µM 0.463461297873038 0.285699528934762 no 951 0.321516874936585 1561 4306703
SGTC_661 1304-0007 33.6 µM 0.462301912498551 0.286145643277787 no 952 0.321932414166782 1511 3117130
SGTC_838 0109-0203 71.4 µM 0.461718264444529 0.286370347566264 no 953 0.322141685770716 1520 759422
SGTC_2199 6590217 200 µM 0.46148504879702 0.286460158920592 no 954 0.322225322851487 1570 703109
SGTC_939 1165-0479 45.3 µM 0.460183956110614 0.286961454885238 no 955 0.322692092981868 1526 1377347
SGTC_2196 6573537 42.6665 µM 0.459449081940302 0.287244776929909 no 956 0.322955854438462 1626 2903087
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.45700506223171 0.288187990863651 no 957 0.323833703467112 1578 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1806 st050005 60.3 µM 0.454921876989873 0.288993100571601 no 958 0.324582721716614 1511 5194765
SGTC_2743 auranofin 4.32 µM 0.454809570533181 0.289036534830002 no 959 0.324623122186194 1574 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2797 7859098 81.82 µM 0.453751578292219 0.289445861485202 no 960 0.325003819378525 1527 972681
SGTC_2000 st075254 36.4 µM 0.453519316362461 0.289535757747272 no 961 0.32508741863681 1522 17234175
SGTC_2025 5147754 141 µM 0.452613947627445 0.289886303017206 no 962 0.32541337680538 1608 315777 YLR208W SEC13
SGTC_1416 3966-0321 25.3 µM 0.451195940020945 0.29043573408228 no 963 0.32592416776847 1551 582530 YLR208W SEC13
SGTC_2466 5983409 37.09 µM 0.450980956239596 0.290519075727192 no 964 0.326001637218148 1536 2879657
SGTC_129 0088-0017 176.636 µM 0.450787433943378 0.290594107080242 no 965 0.326071379441311 1625 182446
SGTC_113 0099-0221 2.5 µM 0.449383036801543 0.29113888331399 no 966 0.326577683021816 1645 89219
SGTC_1235 benzylparaben 21.5 µM 0.448016686721225 0.29166935807834 no 967 0.327070576908231 1551 7180
SGTC_3219 9131112 49.47 µM 0.44716383601437 0.29200069892335 no 968 0.327378385283898 1536 17612988 YMR079W SEC14
SGTC_2580 diallyl disulphide 81.36 µM 0.446452937884158 0.292277023654937 no 969 0.327635050282031 1563 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1740 st038286 13.222 µM 0.445948569917988 0.292473144238598 no 970 0.327817198364321 1593 716786
SGTC_2390 9097792 176.6 µM 0.444892137035729 0.292884130210161 no 971 0.328198852612979 1505 4497149
SGTC_1381 2324-0066 62.1 µM 0.444879623412914 0.2928890000132 no 972 0.32820337444678 1594 10885928
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.443649679853082 0.293367828272752 no 973 0.328647940851995 1531 4000243
SGTC_2768 sulfasalazine 50.2 µM 0.443060769972695 0.293597224611972 no 974 0.328860889850834 1701 5384001 An antioxidant and salicylic acid derivative.
SGTC_1606 st000094 49.2 µM 0.442969236927065 0.293632886666724 no 975 0.328893993064967 1670 1242210
SGTC_2747 doxorubicin 7.63 µM 0.442063831775229 0.293985748200251 no 976 0.329221507956001 1561 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2320 7373003 200 µM 0.441809896064832 0.294084749192213 no 977 0.329313388426177 1488 5415828
SGTC_667 1498-1044 59 µM 0.441504204294892 0.294203948566705 no 978 0.329424009243731 1606 6739982
SGTC_3083 9117465 49.47 µM 0.439089458667921 0.295146321668137 no 979 0.330298358455036 1521 16420915
SGTC_1761 st044296 37 µM 0.438897410821812 0.295221329450507 no 980 0.330367936452373 1536 1826700
SGTC_1974 st069448 26.9 µM 0.438845405177045 0.295241642711548 no 981 0.330386778852876 1662 6323587 YNR016C ACC1
SGTC_2075 5212009 200 µM 0.43872675976048 0.295287987691163 no 982 0.330429767420257 1620 780898
SGTC_250 brefeldin a 552.239 µM 0.437240153028439 0.295868965920285 no 983 0.330968596319336 1520 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2415 st077333 57.7 µM 0.436972969858962 0.295973438947548 no 984 0.331065475519431 1817 2766255
SGTC_2678 equilin 100 µM 0.436445801318372 0.296179620202723 no 985 0.331256657207527 1662 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2426 5582046 32.21 µM 0.435814444027153 0.296426637469319 no 986 0.331485681629452 1598 2251934
SGTC_485 niflumic acid 177 µM 0.435048406376589 0.29672647488192 no 987 0.33176364587844 1607 4488 A COX2 inhibitor.
SGTC_1453 4237-0541 195 µM 0.434859997687791 0.296800241842016 no 988 0.331832026013998 1693 739892
SGTC_2825 7998094 58.44 µM 0.434533107810909 0.296928247744504 no 989 0.331950679132166 1582 2987815
SGTC_3114 9122766 49.47 µM 0.434270466333726 0.297031113090536 no 990 0.332046023847411 1515 17176985
SGTC_1261 0712-0010 12.7 µM 0.432296464285998 0.297804765658955 no 991 0.332762978298566 1693 2840123
SGTC_2377 9073351 62.6 µM 0.429892089436938 0.298748329740177 no 992 0.333637070045402 1548 7337946 YHR072W ERG7
SGTC_1310 1188-0297 994 nM 0.427919797817429 0.299523341656631 no 993 0.334354756359109 1576 1588352
SGTC_3052 9092717 49.47 µM 0.427128830262017 0.299834408136178 no 994 0.334642747545164 1574 25237534
SGTC_3232 9132874 49.47 µM 0.426987903598279 0.299889846188364 no 995 0.334694069143382 1536 3784940
SGTC_1022 4477-0945 21.3 µM 0.425185408272947 0.300599324700203 no 996 0.335350760225022 1566 4648966
SGTC_1249 0481-0015 10.2 µM 0.425011971543531 0.300667630918189 no 997 0.335413973850986 1539 4227577
SGTC_2278 7948257 134.34 µM 0.424436498146561 0.300894325188616 no 998 0.335623753799856 1734 1247028
SGTC_1109 tnp00067 928.257 nM 0.423958819315509 0.301082554105391 no 999 0.335797923173458 1576 676295
SGTC_1400 3771-8998 51.5 µM 0.423286259646499 0.301347665559835 no 1000 0.33604320902172 1644 670767
SGTC_549 1661-1316 519 µM 0.423210090081577 0.301377696916785 no 1001 0.336070992844314 1695 2857282
SGTC_1602 st001878 87.6 µM 0.421988807637947 0.301859395531942 no 1002 0.336516593445416 1645 595405 YLR310C CDC25
SGTC_1980 st071811 45.7 µM 0.42141347857148 0.302086436828519 no 1003 0.33672658927996 1657 4974850
SGTC_135 0933-0004 26.348 µM 0.420644498164656 0.302390018149528 no 1004 0.337007347601174 1538 21230617 YGL099W LSG1
SGTC_2896 9052656 71.43 µM 0.420116781272189 0.302598431581361 no 1005 0.337200072054832 1576 6469436
SGTC_2748 diazoxide 86.69 µM 0.420115533497455 0.302598924446515 no 1006 0.337200527798129 1639 3019 A potassium channel activatior.
SGTC_2815 7968870 71.43 µM 0.419604176361486 0.302800938387482 no 1007 0.337387318463115 1551 2977326 YHR190W ERG9
SGTC_1587 estradiol valerate 56.1 µM 0.419124529105318 0.302990480070755 no 1008 0.337562562444007 1711 13791 A steroid.
SGTC_1985 st071382 65.5 µM 0.418802584190472 0.303117732462664 no 1009 0.337680208041175 1597 6123237
SGTC_2858 9025781 8.96 µM 0.417286716143451 0.303717217542276 no 1010 0.338234351855225 1635 4894980 YPL153C RAD53
SGTC_2398 5228213 48.84 µM 0.416763746382393 0.303924160723885 no 1011 0.338425611151553 1760 80771 YMR134W ERG29
SGTC_863 0466-0191 129 µM 0.414929917012696 0.304650317486462 no 1012 0.3390966041272 1694 765160 YPR165W RHO1
SGTC_1530 rhein 70.4 µM 0.414422085960225 0.304851543937423 no 1013 0.339282508456574 1602 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2557 derrustone 83.84 µM 0.413744768493235 0.305120020726325 no 1014 0.33953051844063 1548 629853 An antioxidant.
SGTC_3108 9121785 49.47 µM 0.413475673472472 0.30522671441011 no 1015 0.33962907093176 1714 17140271
SGTC_1454 4239-0054 42.6 µM 0.412332566918283 0.305680129990962 no 1016 0.340047840745371 1685 1340767
SGTC_1418 3966-3099 2.4 µM 0.412271997154003 0.305704163435453 no 1017 0.340070035604917 1668 740335
SGTC_2634 4'-methoxyflavone 100 µM 0.411276750196474 0.306099186746674 no 1018 0.340434807885474 1598 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_383 2324-0395 7.37 µM 0.411209672498822 0.306125818664065 no 1019 0.340459398198627 1675 3146421
SGTC_866 0495-0101 262 µM 0.41071264906585 0.306323184233287 no 1020 0.340641625368386 1545 635694
SGTC_1491 4138-0063 26.5 µM 0.408853155354535 0.307062078245795 no 1021 0.341323714175368 1681 23883227
SGTC_3264 9137442 49.47 µM 0.407637374527939 0.307545608791061 no 1022 0.341769960511313 1688 17015726
SGTC_1630 st005209 31.3 µM 0.407398865756338 0.307640505859076 no 1023 0.34185752994824 1684 3367314
SGTC_23 0213-0011 39.996 µM 0.406248253360817 0.308098488401899 no 1024 0.342280101300625 1712 627608
SGTC_1139 k015-0024 46.9 µM 0.405814074895173 0.308271383809417 no 1025 0.342439608086796 1712 2766652
SGTC_735 3076-0345 636 µM 0.40569630656237 0.308318287999222 no 1026 0.342482878203108 1722 2888990
SGTC_656 4090-1979 187 µM 0.405148548147337 0.308536487633276 no 1027 0.342684161252886 1743 22330961
SGTC_2619 obliquin 87.91 µM 0.404358016722312 0.308851515158996 no 1028 0.342974734081103 1709 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2164 5685496 200 µM 0.403976144715438 0.309003741925058 no 1029 0.343115130704168 1702 759046
SGTC_193 1273-0060 1.558 µM 0.403321101867328 0.309264939985228 no 1030 0.343356010008646 1602 2847393 YHR072W ERG7
SGTC_1877 wortmannin 25 µM 0.403226906142111 0.30930250842377 no 1031 0.343390653896245 1713 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2772 vinpocetine 57.06 µM 0.402607950558607 0.309549418404245 no 1032 0.343618329936222 1667 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2977 9011197 71.43 µM 0.402520711977241 0.309584226002421 no 1033 0.343650424258103 1669 2704722
SGTC_1148 3909-7663 27.7 µM 0.399471122560944 0.310802062952878 no 1034 0.344773048752599 1702 4084526
SGTC_2684 capsaicin 100 µM 0.398475631896646 0.311200056757493 no 1035 0.345139808611977 1632 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2511 berberine 10.47 µM 0.398202581326909 0.311309260065762 no 1036 0.345240431672115 1618 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1077 5-fluorocytosine 377 nM 0.397409609498637 0.311626493782024 no 1037 0.345532715193684 1633 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3300 9124615 50.48 µM 0.397121861333133 0.31174164396989 no 1038 0.34563879981648 1696 24824903
SGTC_153 4077-0274 519.67 µM 0.397115691418113 0.311744113229393 no 1039 0.345641074622699 1753 3121976
SGTC_2704 st078022 71.1 µM 0.396484462687109 0.311996781766789 no 1040 0.345873833856689 1771 54697681
SGTC_226 1,3-diallylurea 8.28947 mM 0.396069000641164 0.312163131406987 no 1041 0.346027063096783 1660 74537 YKL182W FAS1
SGTC_1716 st033144 30.6155 µM 0.394813874027635 0.3126659125366 no 1042 0.346490127516558 1754 674617
SGTC_3314 9135860 59.4275 µM 0.394359720192904 0.312847924375901 no 1043 0.346657738894459 1756 25252478
SGTC_1364 1653-0028 37.6 µM 0.394312941036628 0.312866674713885 no 1044 0.34667500505626 1645 5718652
SGTC_2808 7946468 45.46 µM 0.393768708631168 0.313084853199618 no 1045 0.34687590434714 1671 2970879
SGTC_2716 st080858 38.6235 µM 0.393170087831641 0.313324911167609 no 1046 0.347096930429056 1706 5296050
SGTC_2625 euphol 100 µM 0.392169902124068 0.313726180553028 no 1047 0.347466340576839 1782 6708538 A triterpene alcohol.
SGTC_936 3005-4620 401 µM 0.391737321468228 0.313899798020668 no 1048 0.347626155503886 1742 777207
SGTC_2472 5377652 49.4 µM 0.390064936359288 0.314571401856755 no 1049 0.348244264998311 1611 1610903
SGTC_2545 solidagenone 89.61 µM 0.389225629114756 0.314908686136816 no 1050 0.348554623026719 1622 6708572 An anti ulcer agent
SGTC_568 1193-0097 7.48 µM 0.38839787111112 0.315241480502743 no 1051 0.348860809712316 1649 3646150
SGTC_1211 1056-0033 32.3 µM 0.38811490856558 0.31535527804453 no 1052 0.348965499805539 1730 6741922
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.387912723709399 0.315436600384131 no 1053 0.349040310923751 1604 2374 Ca(2+)-ATPase inhibitor.
SGTC_2686 alizarin 95.37 µM 0.385734182557992 0.316313414838814 no 1054 0.349846772167752 1585 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.385621707641316 0.316358711599869 no 1055 0.349888427024132 1603 688669
SGTC_154 3389-1638 511.116 µM 0.38556582383062 0.316381218581374 no 1056 0.349909124151517 1529 5238686
SGTC_3075 9116269 49.47 µM 0.385405983903115 0.316445597228172 no 1057 0.349968324926705 1657 17015205 YNL244C SUI1
SGTC_3050 9093513 49.47 µM 0.384830269873482 0.316677523364696 no 1058 0.350181585449554 1631 25236664
SGTC_1220 1838-0075 193 µM 0.383843462082732 0.317075226072894 no 1059 0.3505472364393 1685 5529645
SGTC_1948 st076329 66.6 µM 0.383821489255839 0.31708408395647 no 1060 0.350555379811186 1601 24208413
SGTC_529 4076-0302 30.3 µM 0.382978316141815 0.317424070625542 no 1061 0.350867920914292 1635 5816522
SGTC_901 1112-0062 60.1 µM 0.38214288134492 0.317761089013824 no 1062 0.351177693192243 1658 1908457
SGTC_2953 9074162 66.49 µM 0.382083828823962 0.317784916801479 no 1063 0.351199593121187 1806 16451992
SGTC_487 nimodipine 119 µM 0.381338871234041 0.318085573171391 no 1064 0.351475906861436 1724 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3124 9127567 49.47 µM 0.380636259778495 0.318369249022506 no 1065 0.351736585852455 1764 17592030
SGTC_992 3909-8734 162 µM 0.379233234881153 0.318936031936897 no 1066 0.352257336860676 1631 4288319
SGTC_1564 D-Arginine 115 µM 0.37782403836386 0.319505734529026 no 1067 0.352780657527884 1565 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2088 5278280 127.392 µM 0.377409023556783 0.319673595859071 no 1068 0.352934831019572 1676 791502
SGTC_3354 9151612 71.43 µM 0.377299484732149 0.319717907268375 no 1069 0.352975527532001 1765 27261949
SGTC_51 1013-0126 23.419 µM 0.377140423607998 0.319782256365026 no 1070 0.353034625856631 1792 1627850
SGTC_815 1582-0027 36.9 µM 0.37462849325643 0.32079919049762 no 1071 0.353968389622502 1709 3128206
SGTC_1282 0886-0010 32.4 µM 0.372755909290812 0.321558166909327 no 1072 0.354665060406476 1790 2836211 YNL267W PIK1
SGTC_14 0354-0009 295 µM 0.372492425070642 0.32166501951134 no 1073 0.354763125409995 1711 1713507
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.371971743782633 0.3218762184209 no 1074 0.35495694372856 1799 6728940
SGTC_3329 9141233 27.5565 µM 0.370519991059078 0.322465382607639 no 1075 0.355497542047568 1746 4909101 YNL103W MET4
SGTC_2246 7293507 91.5585 µM 0.369730118996779 0.322786123556894 no 1076 0.355791793932519 1831 887656
SGTC_2740 felodipine 17.08 µM 0.369456094413033 0.322897426711003 no 1077 0.355893896692393 1784 3333 L-type calcium channel blocker
SGTC_1008 4106-0037 6 µM 0.366998103435919 0.323896520511756 no 1078 0.356810216345702 1684 2905394
SGTC_1657 st012939 43.4 µM 0.36605077797524 0.324281917145353 no 1079 0.35716359284586 1770 24207257
SGTC_439 amiodarone 34.4 µM 0.365604760734784 0.324463433793019 no 1080 0.357330011077612 1745 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1618 st003135 44.5 µM 0.364547801115069 0.324893753534448 no 1081 0.357724492821808 1756 1270615
SGTC_3178 9107506 49.47 µM 0.363642770600098 0.325262404211918 no 1082 0.358062391948747 1712 8897194
SGTC_452 diindolylmethane 8 µM 0.363437118610747 0.325346197347865 no 1083 0.358139188995656 1717 3071 Inhibits expression of several cancer promoting factors.
SGTC_932 2857-0803 154 µM 0.362728626567364 0.325634940824418 no 1084 0.358403806576162 1791 674898
SGTC_205 1486-1330 71.903 µM 0.361626199306991 0.326084439302597 no 1085 0.358815691834646 1709 4118834
SGTC_1367 1812-0510 76.9 µM 0.361170036315031 0.326270507031027 no 1086 0.35898617002004 1720 1142582 YDR527W RBA50
SGTC_136 0097-0015 404.482 µM 0.360959818900925 0.326356268742229 no 1087 0.359064742367547 1755 4861337
SGTC_736 0958-0254 92.6 µM 0.360637933107853 0.326487605228032 no 1088 0.359185064231451 1727 6812352
SGTC_360 0957-0399 1.01 µM 0.35825722187093 0.327459654823786 no 1089 0.360075414140534 1778 6752301 YPR165W RHO1
SGTC_1281 0884-0031 11.8 µM 0.357788549920509 0.327651152754417 no 1090 0.360250779983503 1654 1548255
SGTC_644 1498-1197 63.3 µM 0.354754137310912 0.32889209978671 no 1091 0.361386894774528 1750 6741615
SGTC_756 0508-1999 28.3 µM 0.354317839667019 0.329070682769205 no 1092 0.361550349861668 1611 6753853
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.35416350805668 0.329133862289919 no 1093 0.361608174898187 1757 5377381
SGTC_716 1683-5115 658 µM 0.354137943838564 0.329144328115877 no 1094 0.361617753615993 1757 723597
SGTC_2496 diffractaic acid 79.83 µM 0.353777298719292 0.329291988167464 no 1095 0.361752893833679 1820 94870 An apoptosis inducer which activates caspases.
SGTC_3283 9109332 35.8195 µM 0.353730626810092 0.329311099138844 no 1096 0.361770383898606 1657 17027281
SGTC_1834 st055981 52.8 µM 0.351860025535548 0.330077429918085 no 1097 0.362471619738113 1808 471719 YDL150W RPC53
SGTC_8 0354-0001 70 µM 0.350902394478211 0.330470019779961 no 1098 0.362830787521362 1714 4993152
SGTC_468 gf-109203x 121 µM 0.350895149571021 0.330472990609694 no 1099 0.362833505246702 1800 2396 A protein kinase C inhibitor.
SGTC_2336 9001819 198.65 µM 0.350349629484643 0.330696715978529 no 1100 0.363038161764809 1790 2989602
SGTC_1160 4092-0570 10.5 µM 0.35020563565817 0.330755779943144 no 1101 0.363092188805947 1635 4994975
SGTC_1002 4049-0206 172 µM 0.349448217922251 0.331066529934955 no 1102 0.363376419706658 1651 4662749
SGTC_2225 6654152 15.4 µM 0.349171295008742 0.331180173711356 no 1103 0.363480357438535 1758 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2949 9072542 2.23 µM 0.349158077978058 0.33118559811254 no 1104 0.363485318450172 1642 16457352
SGTC_1795 st049545 62.3 µM 0.348876733727528 0.331301072999829 no 1105 0.363590926426252 1833 5291882
SGTC_685 1278-0033 54.9 µM 0.348128490399138 0.331608259909448 no 1106 0.363871844378384 1777 3590572
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.348057917174903 0.331637239182191 no 1107 0.363898343930718 1741 2724278 An inhibitor of dopamine biosynthesis.
SGTC_367 0335-0881 7.1 µM 0.343302573447968 0.333592225722355 no 1108 0.365685422499413 1796 23828853
SGTC_1040 k898-0338 155 µM 0.343164930862373 0.333648880131348 no 1109 0.365737192825401 1877 20969351
SGTC_2397 5161689 200 µM 0.341576637290592 0.33430290424378 no 1110 0.36633476076914 1779 2259942
SGTC_1450 4112-4260 37.6 µM 0.341271478509801 0.33442861957341 no 1111 0.366449608652988 1835 1633175
SGTC_1634 st006576 41 µM 0.341037375355499 0.334525074922 no 1112 0.366537722539426 1857 3915356
SGTC_3068 9116768 49.47 µM 0.340674812690846 0.334674479806476 no 1113 0.366674201074616 1709 41904888
SGTC_2265 7929201 200 µM 0.340648557630446 0.334685300013025 no 1114 0.366684084854545 1638 1265108
SGTC_940 3232-1287 54.8 µM 0.336778046236696 0.336281908544597 no 1115 0.368142111932139 1835 1585493 YIL048W NEO1
SGTC_3190 9110366 49.47 µM 0.33645603393411 0.33641487414226 no 1116 0.368263500377849 1861 17123768
SGTC_3325 9138760 55.175 µM 0.336229158720063 0.336508567938921 no 1117 0.368349033050766 1666 43844959
SGTC_1557 sumaresinolic acid 42.3 µM 0.334240588633476 0.337330231615414 no 1118 0.36909900906145 1685 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3011 9081274 71.4286 µM 0.332319916924123 0.338124577379356 no 1119 0.369823851075299 1715 6625322
SGTC_478 N-arachidonylglycine 10 µM 0.331595241088522 0.338424474265982 no 1120 0.370097456759672 1819 5283389
SGTC_1019 4262-0212 3.4 µM 0.331109153089752 0.338625692392035 no 1121 0.370281019036598 1866 4677213
SGTC_2331 7980721 200 µM 0.330995849361419 0.338672601559668 no 1122 0.370323810372986 1827 2981221
SGTC_2594 a-mangostin 100 µM 0.329569645804334 0.339263281567096 no 1123 0.370862580706272 1856 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_84 0443-0269 128.823 µM 0.329184803544007 0.339422736564869 no 1124 0.371008004227355 1785 6150058
SGTC_311 1315-0136 58 µM 0.32804676299356 0.339894438825126 no 1125 0.371438152727949 1810 6759207
SGTC_2856 9022925 19.48 µM 0.325538421417242 0.340934996828542 no 1126 0.372386804340036 1754 4944862
SGTC_2567 aureobasidin a 60 nM 0.324791817091969 0.341244951721041 no 1127 0.372669319052399 1775 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1098 clofazimine 15.1 µM 0.324345732947925 0.341430195957122 no 1128 0.372838149781921 1815 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1426 4048-4480 71.7 µM 0.324231928362178 0.341477461419123 no 1129 0.372881225638195 1819 14224343
SGTC_673 1082-0474 110 µM 0.323772229799028 0.341668409295995 no 1130 0.373055241031482 1707 3098046
SGTC_207 4185-0010 4.486 µM 0.323154691227226 0.341924983943931 no 1131 0.373289046322295 1832 3761753
SGTC_2651 TUB2.036 5 µM 0.322862871551548 0.342046254465524 no 1132 0.373399547943197 1825 15992207 YFL037W TUB2
SGTC_309 k408-0051 1.48 µM 0.32136356731213 0.342669571990689 no 1133 0.373967444542619 1753 3640463
SGTC_2913 7966556 36.57 µM 0.32017062292339 0.343165830427387 no 1134 0.37441949574604 1836 2976516
SGTC_1314 1222-0010 41.1 µM 0.32015584476112 0.343171979761808 no 1135 0.374425096828007 1776 3526027
SGTC_2543 pimpinellin 60.67 µM 0.318919854853887 0.343686433806877 no 1136 0.374893643943462 1705 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1540 guanosine 70.6 µM 0.318669775724558 0.343790559090237 no 1137 0.374988468061105 1839 6802 Guanosine is a purine nucleoside
SGTC_731 3966-0296 387 µM 0.318236565717675 0.343970962498658 no 1138 0.375152748976883 1752 660956
SGTC_2241 6772625 37.8075 µM 0.317079903820242 0.344452809880809 no 1139 0.375591486571774 1694 2285411
SGTC_325 2810-4341 181 µM 0.31647228861794 0.344706034167355 no 1140 0.375822027796606 1873 774970
SGTC_790 1575-0012 79.1 µM 0.315459012959309 0.345128472637305 no 1141 0.376206583199891 1879 378741 YLR208W SEC13
SGTC_1059 3448-6867 171 µM 0.31534144312332 0.345177500458438 no 1142 0.376251210925675 1917 3934407
SGTC_3040 9091894 49.47 µM 0.312813035967209 0.346232499700633 no 1143 0.377211355403995 1843 25236966
SGTC_2860 9025725 38.96 µM 0.312655373331981 0.346298325409634 no 1144 0.377271251878953 1691 40546248
SGTC_969 1313-0238 134 µM 0.312283846018424 0.346453460095468 no 1145 0.377412407816163 1750 5212874
SGTC_406 estrone 100 µM 0.312137116288747 0.346514735556063 no 1146 0.377468159972853 1879 5870 A steroid.
SGTC_1377 2944-0135 198 µM 0.311916752660752 0.346606768642625 no 1147 0.377551895228017 1781 1894137
SGTC_2175 5807670 165.306 µM 0.311190619453926 0.346910096350597 no 1148 0.377827856924653 1862 241186
SGTC_1786 berberine 21.6 µM 0.310568086490113 0.347170225259768 no 1149 0.378064495752825 1706 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_519 k048-0011 62.8 µM 0.309778473875143 0.34750027294378 no 1150 0.378364711140465 1804 6836379
SGTC_2644 guaiazulene 100 µM 0.309541734353927 0.347599249494001 no 1151 0.378454735225386 1852 3515 A coloring agent.
SGTC_1161 k007-0610 110 µM 0.305216473836057 0.349409386254431 no 1152 0.380100643176713 1831 5843850
SGTC_1329 1447-1697 50.6 µM 0.303586795844351 0.350092304212262 no 1153 0.380721356235452 1789 2840515
SGTC_1845 st056753 3.01 µM 0.301789511147305 0.350846020383512 no 1154 0.381406263595773 1701 5375839
SGTC_2024 5144227 134 µM 0.301179358187407 0.351102030150595 no 1155 0.381638864633195 1841 3475211
SGTC_1656 st012921 11 µM 0.300045413015462 0.351577993655682 no 1156 0.382071257958275 1863 6732821
SGTC_1039 k821-0043 94 µM 0.298804830456759 0.352098983907334 no 1157 0.382544482531352 1880 15992768
SGTC_3001 9076041 71.4286 µM 0.298637142212209 0.35216942694315 no 1158 0.382608461276438 1775 16004211
SGTC_54 0159-0055 9 µM 0.298588659990045 0.352189794461814 no 1159 0.382626959483499 1903 3319099
SGTC_864 0469-0573 172 µM 0.298074007455295 0.352406027575505 no 1160 0.382823339697517 1734 689425
SGTC_894 0960-0238 55.9 µM 0.296496636227598 0.353069062725032 no 1161 0.383425417725476 1900 6741907 YDL195W SEC31
SGTC_1305 1181-0477 144 µM 0.294374550676463 0.353961768022706 no 1162 0.384235855719782 1905 6252086
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.292849515031241 0.354603806680605 no 1163 0.384818589490475 1876 6710655
SGTC_1392 3455-1037 33.9 µM 0.29249061670264 0.354754962703876 no 1164 0.384955766580538 1874 981132
SGTC_1635 st007035 42.4 µM 0.292442753851514 0.35477512267163 no 1165 0.384974061670918 1778 3716403
SGTC_328 k915-0120 63.5 µM 0.292046446365321 0.354942064122325 no 1166 0.385125556031125 1905 6624543
SGTC_3149 9097855 49.47 µM 0.291688041364249 0.355093063432442 no 1167 0.385262576709676 1920 25236625 YMR079W SEC14
SGTC_3177 9107506 49.47 µM 0.290161438617929 0.355736489831647 no 1168 0.385846367623285 1891 8897194
SGTC_3101 9120531 49.47 µM 0.290004342920764 0.355802725262618 no 1169 0.385906457571697 1894 24824904
SGTC_2254 7938975 95.19 µM 0.289885486688115 0.355852840882617 no 1170 0.38595192253869 1879 2969277
SGTC_2035 5154463 94.595 µM 0.289670794494703 0.355943371959907 no 1171 0.386034050712605 1892 2769623
SGTC_2736 butenafine 14.65 µM 0.288570848547582 0.356407322820906 no 1172 0.38645490316988 1868 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_26 0302-0163 425.158 µM 0.287159952452845 0.357002741844404 no 1173 0.386994924401184 1843 3100915
SGTC_968 1309-0633 340 µM 0.285227670202258 0.357818758755412 no 1174 0.38773486134513 1920 3761976
SGTC_271 rotenone 740 µM 0.284772927108539 0.35801089473895 no 1175 0.38790905741516 1885 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_42 0133-0086 60.653 µM 0.284671219359974 0.358053872758288 no 1176 0.387948021161293 1724 162923 Model of phenazepam hydroxylation.
SGTC_2810 7959871 45.46 µM 0.284564634774555 0.358098913483065 no 1177 0.387988854410593 1866 2974535
SGTC_1686 st019653 115.5 µM 0.283286652694323 0.358639119328601 no 1178 0.388478554005635 1930 97252
SGTC_505 gw-5074 63.9 µM 0.283014927006166 0.358754014888217 no 1179 0.388582697253742 1881 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_858 0438-0351 2.77 µM 0.282583357318799 0.358936524607177 no 1180 0.388748119749245 1785 2799119
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.281910500500503 0.359221138275308 no 1181 0.389006068865225 1824 7104
SGTC_2220 6782180 200 µM 0.280877951559677 0.359658051086528 no 1182 0.389402006137236 1909 833803
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.280385054253966 0.359866680416768 no 1183 0.389591051175574 1781 6312947
SGTC_1496 4469-0713 57.4 µM 0.280219028776471 0.359936963657109 no 1184 0.389654734204422 1923 746691
SGTC_1729 st035615 45.989 µM 0.27933369964221 0.360311828212715 no 1185 0.389994373279096 1781 17385451
SGTC_733 4069-0007 56.1 µM 0.276736126439191 0.36141246230693 no 1186 0.390991364939897 1857 5717425 YNL287W SEC21
SGTC_949 1165-0505 146 µM 0.27491330357227 0.362185508089482 no 1187 0.391691423022278 1763 6244267
SGTC_2127 5253358 187.912 µM 0.273095589984548 0.362956947211145 no 1188 0.392389868305438 1776 20612
SGTC_1047 2043-3044 82 µM 0.272267758597867 0.363308464129046 no 1189 0.392708072496505 1766 669592
SGTC_1068 loratadine 26.9 µM 0.272166693032081 0.363351386867531 no 1190 0.392746925284209 1798 3957 A H1 histamine antagonist.
SGTC_3054 9094397 49.47 µM 0.271502187103725 0.363633646508476 no 1191 0.393002408896544 1774 2598354
SGTC_3296 9122258 64.045 µM 0.269261393782019 0.36458600466695 no 1192 0.39386426934102 1836 4730474
SGTC_3031 9088762 49.47 µM 0.268754883186699 0.364801392519962 no 1193 0.394059157141295 1831 205253
SGTC_319 1348-1596 45.5 µM 0.267638780256911 0.365276153103117 no 1194 0.394488688614752 1952 5380505
SGTC_576 1073-0113 22.7 µM 0.267488015585711 0.365340300245493 no 1195 0.394546720147578 1961 5439563
SGTC_450 aminopyrene 156 nM 0.267449353526363 0.365356750731659 no 1196 0.394561602118256 1922 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2487 5918373 44.05 µM 0.266705885691478 0.365673140213918 no 1197 0.39484781094882 1972 2876279
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.266415631299517 0.36579668542331 no 1198 0.394959564040222 1760 23665772 A membrane-active detergent.
SGTC_1467 k284-1082 293 µM 0.265882839608544 0.36602350153874 no 1199 0.395164720780174 1947 3334705
SGTC_1136 pergolide 1.05886 µM 0.265323705538058 0.366261582295074 no 1200 0.395380052170055 1815 47811 A dopamine receptor agonist.
SGTC_825 1988-2224 89.6 µM 0.265118410497281 0.366349010390979 no 1201 0.395459122564775 1830 1180859
SGTC_137 0438-0332 85.389 µM 0.263932561202878 0.366854158455701 no 1202 0.395915942385129 1889 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1464 k208-0027 110 µM 0.263611528030573 0.366990951871256 no 1203 0.396039637288293 1938 X1464
SGTC_1903 st060211 78.3 µM 0.263533422595819 0.367024235439327 no 1204 0.396069733096 1958 688960
SGTC_3245 9134821 49.47 µM 0.262969564836632 0.367264545388572 no 1205 0.396287018735639 1765 17014901
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.262208907794931 0.367588811399434 no 1206 0.396580193084449 1920 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2323 6148992 148.28 µM 0.261485793528356 0.367897160582706 no 1207 0.396858951826445 1806 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1035 k081-0041 55.2 µM 0.261050340275171 0.368082886925592 no 1208 0.397026843405452 1961 731709
SGTC_1769 st044406 64.4 µM 0.259911529595979 0.368568749830193 no 1209 0.397466008754132 1825 670903
SGTC_3266 9136860 49.47 µM 0.259569030354671 0.36871491507181 no 1210 0.3975981139308 1829 4871271 YPR165W RHO1
SGTC_1817 st052116 64.4 µM 0.258984614032383 0.368964364880387 no 1211 0.397823555910079 1927 4361398
SGTC_2041 5107442 45.335 µM 0.25842730212716 0.369202296979577 no 1212 0.398038573991671 1952 793005
SGTC_2437 5741531 144.16 µM 0.25830023433468 0.369256552807145 no 1213 0.398087602713732 1965 2262990
SGTC_1909 st060837 51.5 µM 0.258294162207455 0.369259145569382 no 1214 0.398089945665885 1797 678937
SGTC_64 000l-0018 272.079 µM 0.256614857904236 0.369976426405735 no 1215 0.398738052030698 1811 6811119
SGTC_2285 7945142 200 µM 0.255671881218522 0.370379398374228 no 1216 0.399102104599899 1825 2970608
SGTC_12 0849-0099 9.267 µM 0.255409207120132 0.370491674967261 no 1217 0.399203530154118 1962 6071388
SGTC_2002 4023503 131 µM 0.253750108616216 0.371201089377462 no 1218 0.399844309794039 2047 4736863 YCR052W RSC6
SGTC_2260 7964312 200 µM 0.253357188334794 0.371369162492232 no 1219 0.399996103663648 1976 231951
SGTC_3181 9108277 49.47 µM 0.252953252304748 0.371541973206852 no 1220 0.400152168915609 1833 17097298
SGTC_2008 4012253 172 µM 0.252912671063829 0.371559335984929 no 1221 0.400167848818766 1835 603940
SGTC_1349 flufenamic acid 69 µM 0.251731074311466 0.372064999337915 no 1222 0.400624468223407 1841 3371 A non-steroidal anti-inflammatory.
SGTC_86 0417-1630 471.922 µM 0.250702570480572 0.372505326418629 no 1223 0.401022036591059 1980 3634867
SGTC_1813 st051246 8.6015 µM 0.248558809426573 0.37342365703351 no 1224 0.401851036971328 1974 5291959
SGTC_473 2-arachidonoylglycerol 10 µM 0.247974887924062 0.373673918453768 no 1225 0.402076918307382 1803 5282280 An endocannabinoid.
SGTC_3098 9119039 49.47 µM 0.247093596030968 0.374051729941561 no 1226 0.40241789486441 1859 17161528
SGTC_978 1416-0512 87.4 µM 0.247056741934886 0.374067532000351 no 1227 0.402432155531083 1869 6814003
SGTC_2910 7948405 25.97 µM 0.246839716204045 0.374160591168281 no 1228 0.402516136118743 1989 2971328
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.246611971146451 0.374258254596695 no 1229 0.402604269510189 1853 689007
SGTC_2363 9053361 176 µM 0.245138406218394 0.374890355078069 no 1230 0.403174633047693 1968 6469797 YMR079W SEC14
SGTC_3155 9099265 49.47 µM 0.243639450057004 0.37553369237484 no 1231 0.403755036028692 1921 25236499
SGTC_1492 4158-0558 28.5 µM 0.238501083489076 0.377741646811205 no 1232 0.405746237546784 1966 3967268
SGTC_1223 0764-0573 147 µM 0.237737921022961 0.378069920427103 no 1233 0.406042185005589 1884 1609797
SGTC_277 nystatin 15.5 µM 0.237657736422655 0.378104416873225 no 1234 0.406073282984117 1832 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2 0422-0095 29 µM 0.236359119810474 0.378663233577156 no 1235 0.406577007606881 1904 6790840
SGTC_1612 st002233 45.4 µM 0.236216616865345 0.378724570479628 no 1236 0.406632292967933 1977 1035021
SGTC_1050 3232-1156 69.3 µM 0.235657870102306 0.378965098796367 no 1237 0.406849081986468 1850 700529
SGTC_3216 9129716 49.47 µM 0.231202280765791 0.380884803104207 no 1238 0.40857882910461 1865 8056934
SGTC_33 0986-0033 35.816 µM 0.229714105651247 0.381526644324024 no 1239 0.409156966635442 1977 2848082
SGTC_1433 4060-0023 7.6 µM 0.22967271986108 0.381544498439185 no 1240 0.409173047331082 1974 3840627
SGTC_381 3461-2219 42.7 µM 0.229360506511336 0.381679197550887 no 1241 0.409294364614716 1998 2883159
SGTC_2315 7733312 200 µM 0.22857167395947 0.382019589671658 no 1242 0.409600921329092 1858 726316
SGTC_1707 st032323 6.317 µM 0.227471747595152 0.382494375291478 no 1243 0.410028467798881 1941 3132057 YMR211W DML1
SGTC_1900 st060200 72.8 µM 0.22733129547531 0.38255501449209 no 1244 0.410083069901235 1865 688945
SGTC_1807 st050092 58.9 µM 0.226699474314766 0.382827834364551 no 1245 0.410328717955743 1912 5008496
SGTC_961 1252-1571 372 µM 0.226689009493749 0.382832353555783 no 1246 0.41033278690818 2014 6813498
SGTC_855 0428-0020 25 µM 0.225308894730339 0.383428490161676 no 1247 0.410869490281731 1893 6812414
SGTC_2880 9042983 58.44 µM 0.224796605782884 0.383649842237457 no 1248 0.41106875334995 1899 6464714
SGTC_32 0928-0142 34.1 µM 0.223023902205789 0.384416092480398 no 1249 0.411758451850517 2000 2244242
SGTC_2873 9040596 71.43 µM 0.222956462723014 0.384445252104274 no 1250 0.411784695651291 1853 6463863
SGTC_2991 9074669 71.4286 µM 0.222608604811 0.384595670013545 no 1251 0.411920069409311 1973 17333109
SGTC_2575 plumbagin 510 nM 0.222235276685058 0.384757120877235 no 1252 0.412065366918599 1830 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1694 st024011 44.9 µM 0.219336308079452 0.386011497749341 no 1253 0.413194040330298 2000 2787533
SGTC_1383 3049-0032 20.7 µM 0.21890925246272 0.386196384806709 no 1254 0.413360369423976 2016 712864
SGTC_2063 5246145 200 µM 0.218121266831892 0.386537598689291 no 1255 0.413667313889606 1964 711240
SGTC_2955 9076254 12.21 µM 0.217030014229241 0.387010278219215 no 1256 0.414092477190286 2027 16459619
SGTC_705 1124-0212 310 µM 0.215218689366539 0.38779522904759 no 1257 0.414798410163081 2042 9554485
SGTC_298 1391-0729 10 µM 0.21515084788836 0.38782463757925 no 1258 0.414824855583566 1894 3237558
SGTC_2982 9019404 25.97 µM 0.215145551769486 0.387826933415379 no 1259 0.41482692009036 1720 22333232
SGTC_2010 4012422 159 µM 0.21498688333105 0.387895717060856 no 1260 0.41488877252483 1944 952393
SGTC_2539 epi(13)torulosol 80 µM 0.214806840184732 0.387973771020625 no 1261 0.414958959844192 1867 6708597
SGTC_1027 k015-0025 8.67 µM 0.213912219712484 0.388361682174481 no 1262 0.415307755419305 1866 3598955
SGTC_2475 5812728 15.03 µM 0.213522865985596 0.388530542377699 no 1263 0.415459577926203 2017 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1428 4049-0204 61.7 µM 0.212404186420472 0.389015823620148 no 1264 0.415895860000837 2028 X1428
SGTC_503 tyrphostin 8 294 µM 0.212367449554298 0.38903176294984 no 1265 0.415910189042705 2031 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3311 9131146 2.8755 µM 0.21208541970368 0.389154135805591 no 1266 0.416020197181538 1934 4900406 YPR165W RHO1
SGTC_2061 5245884 80.95 µM 0.210542927043533 0.389823618160573 no 1267 0.416621975736963 1919 573863
SGTC_695 3505-6186 243 µM 0.208071837878909 0.390896816628801 no 1268 0.417586438016837 1974 1819379
SGTC_459 nigericin 15.3 µM 0.206765296483564 0.391464586472086 no 1269 0.41809657992399 1960 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1966 st070145 16.1 µM 0.206551503830469 0.391557514132346 no 1270 0.418180068871033 1931 3748532
SGTC_1212 0520-0165 585 µM 0.206459634055416 0.391597448384654 no 1271 0.418215946404009 2070 5403258
SGTC_2789 5281112 71.43 µM 0.206395372404378 0.39162538252696 no 1272 0.418241042652088 1856 765948
SGTC_2289 7946404 165.07 µM 0.205862216010892 0.391857163852323 no 1273 0.418449270253257 1919 1246120 YPR165W RHO1
SGTC_732 3970-1727 52.7 µM 0.205638975126047 0.391954225709184 no 1274 0.418536465184439 2061 1275699
SGTC_18 0111-0177 500 nM 0.20451548368412 0.392442805243323 no 1275 0.418975346733021 1946 721752
SGTC_1638 st008370 60.6 µM 0.204128174968791 0.392611275877251 no 1276 0.419126668707022 2003 24207134
SGTC_933 2914-0560 114 µM 0.202872784658506 0.393157480774465 no 1277 0.419617233314848 2098 463887
SGTC_2799 7812892 81.82 µM 0.200042441500707 0.39438969866183 no 1278 0.420723694192567 2037 20205235
SGTC_2452 5863136 48.41 µM 0.19956099878437 0.394599405099077 no 1279 0.420911966309877 1961 2184096
SGTC_3016 9080866 49.47 µM 0.199173008075179 0.394768428016664 no 1280 0.421063706419704 1968 17066299
SGTC_1891 st059073 26.2 µM 0.197986663816775 0.395285365644438 no 1281 0.42152774896513 2087 688754
SGTC_617 3770-0098 35 µM 0.197006213626657 0.395712726157349 no 1282 0.421911337651972 1941 5962639
SGTC_1207 2099-0101 141 µM 0.196766770102562 0.395817114333973 no 1283 0.422005028161713 2067 5837381
SGTC_1228 0124-0032 52.5 µM 0.196328519176404 0.396008194250196 no 1284 0.422176520331424 2029 X1228
SGTC_2681 menadione 3.18 µM 0.196114595513353 0.396101475272955 no 1285 0.422260236258903 1977 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_10 0279-0212 42.575 µM 0.195612567324167 0.39632040710304 no 1286 0.422456711506571 2010 39851 YBR002C RER2
SGTC_3153 9100258 49.47 µM 0.194949088420225 0.396609796887124 no 1287 0.422716402180332 1900 25236848
SGTC_1571 st070080 73.4 µM 0.194708907783867 0.396714570594637 no 1288 0.422810418989476 2022 4315245
SGTC_1785 bathophenanthroline 24 µM 0.194424774382877 0.396838527392016 no 1289 0.422921646437422 1886 72812 An iron chelator.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.192333159095403 0.397751341113627 no 1290 0.423740623019564 2033 17037758
SGTC_827 3253-0474 693 µM 0.188928217574522 0.399238506989359 no 1291 0.425074538698876 2074 5402065
SGTC_3212 9128307 49.47 µM 0.188727517332556 0.399326212104392 no 1292 0.425153191712434 1750 27243542
SGTC_2117 5521686 200 µM 0.187047600888727 0.400060527002409 no 1293 0.425811655693525 1931 803312
SGTC_2739 tacrine 100.86 µM 0.185933581518004 0.400547675509603 no 1294 0.426248423559735 1999 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1519 esterone 74 µM 0.185705158692057 0.400647581458588 no 1295 0.426337991321796 1859 698 A steroid.
SGTC_1475 4092-1048 11.7 µM 0.183807497932846 0.401477817510564 no 1296 0.427082236929853 1990 2881759
SGTC_2233 sulbentine 40.3845 µM 0.183740845368328 0.401506986450593 no 1297 0.427108382205663 2039 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_361 000s-0510 1.45 µM 0.183538695403848 0.401595456022676 no 1298 0.427187679935673 1974 660
SGTC_1403 3909-7815 62.9 µM 0.183376856902464 0.40166628718982 no 1299 0.427251166736347 1982 6615483
SGTC_2342 7990637 118.86 µM 0.182483395567104 0.402057382693667 no 1300 0.427601691998862 1978 2033102 YER133W GLC7
SGTC_453 enantio-paf c16 10 µM 0.18140796627623 0.402528261223111 no 1301 0.428023683217959 2062 13871343 A lipid and platelet activating factor
SGTC_1429 4049-0205 9.46 µM 0.181267386994701 0.402589824566912 no 1302 0.42807885167726 2068 22774478
SGTC_2114 5491910 81.25 µM 0.181032830816887 0.402692548228338 no 1303 0.428170903242063 2047 2849228
SGTC_2177 5811945 192 µM 0.180762109825528 0.402811118587844 no 1304 0.428277152545809 2052 5343475
SGTC_942 3253-1115 227 µM 0.179053234883986 0.40355977738388 no 1305 0.428947950827131 2073 46497897
SGTC_2546 rhodinyl acetate 100 µM 0.178903942030632 0.403625199473636 no 1306 0.429006563716884 2112 6708682
SGTC_107 0358-0022 2.6945 µM 0.178709945940005 0.403710215137778 no 1307 0.429082729590618 2082 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1866 st057638 64 µM 0.17844462728373 0.403826494133497 no 1308 0.429186902084521 1973 688802
SGTC_167 3672-0051 66.205 µM 0.177614678800944 0.404190283571799 no 1309 0.429512797914465 2008 3237971
SGTC_1531 st059297 52.4 µM 0.177412174507019 0.404279059408622 no 1310 0.429592322565357 2027 7566702
SGTC_1127 asiatic acid 681.4 nM 0.17700998006064 0.404455392003747 no 1311 0.429750275206177 1889 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1776 st049249 45.9 µM 0.176632887937384 0.404620736712824 no 1312 0.429898379700545 1937 1822314
SGTC_1058 3448-5425 97.3 µM 0.176315614698738 0.404759865653223 no 1313 0.430022997722729 2093 7279705
SGTC_1209 2323-2347 50.3 µM 0.175433714702863 0.405146654858506 no 1314 0.43036942542755 2127 5412760
SGTC_2778 tioconazole 65.09 nM 0.17484886067027 0.40540321492145 no 1315 0.430599197198677 2033 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_914 3820-6779 408 µM 0.174602618494766 0.405511247046542 no 1316 0.430695945466417 2016 2893481
SGTC_1449 4112-4002 201 µM 0.174113770063289 0.405725737457293 no 1317 0.430888025773864 1920 2059539
SGTC_96 0929-0093 37.281 µM 0.173001362324237 0.406213930326817 no 1318 0.431325178395103 1957 6991579
SGTC_2144 5628481 200 µM 0.172649036517922 0.406368582987835 no 1319 0.431463652525027 1988 2818399
SGTC_2436 5633522 8.09 µM 0.172246137755562 0.406545452442387 no 1320 0.431622013597635 2125 5724242
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.17191892805178 0.406689109015809 no 1321 0.431750632852158 2089 165521
SGTC_1132 3456-3614 2.5 µM 0.171669273894814 0.406798724422239 no 1322 0.431848771518939 2131 3125502
SGTC_2924 9010168 62.78 µM 0.171645695965527 0.406809077138096 no 1323 0.431858040184302 1990 2993929
SGTC_3237 9133362 49.47 µM 0.171641360343792 0.406810980851797 no 1324 0.431859744554638 2100 43845137
SGTC_61 0978-8327 98.565 µM 0.170778694039699 0.407189809876253 no 1325 0.432198891318911 2129 6150059 YHR072W ERG7
SGTC_1849 st056239 19.2 µM 0.169819853613667 0.40761097443668 no 1326 0.4325759063938 1887 5393181
SGTC_1309 pyrazolanthrone 13.4 µM 0.169311286902799 0.407834402510403 no 1327 0.432775899243295 2117 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3215 9129942 49.47 µM 0.168455385845696 0.408210492258619 no 1328 0.433112519489282 2135 17682944
SGTC_907 3448-6986 75.5 µM 0.16649163621728 0.409073698587072 no 1329 0.433885032323511 2102 590582
SGTC_3049 9092223 49.47 µM 0.165671198553045 0.40943446964502 no 1330 0.434207856508357 2024 8623917
SGTC_2109 5483026 200 µM 0.16533166577064 0.409583794856614 no 1331 0.43434146804417 2004 759335
SGTC_106 0092-0003 11.579 µM 0.165310118122094 0.409593271872425 no 1332 0.434349947638943 2121 1072148
SGTC_2174 5790901 200 µM 0.162791891665067 0.410701192350194 no 1333 0.435341146309841 2004 786020
SGTC_535 2293-4129 48.2 µM 0.162558168765468 0.410804057509907 no 1334 0.435433162643932 2117 396118 YIL048W NEO1
SGTC_778 3456-2434 196 µM 0.161709471506986 0.411177634184086 no 1335 0.435767322766329 2137 5539063
SGTC_3030 9087619 49.47 µM 0.161688562990956 0.411186838641768 no 1336 0.435775555719022 2025 25236973
SGTC_3332 9141069 11.198 µM 0.161524223333161 0.41125918681843 no 1337 0.435840267192723 1962 17332883
SGTC_1747 st037496 66.6 µM 0.161440117935463 0.411296214180845 no 1338 0.435873385756608 2032 723305
SGTC_1667 st014849 34.6 µM 0.159970421985014 0.41194337440586 no 1339 0.436452186980433 2112 5348460
SGTC_1186 1319-0216 26 µM 0.158806278208901 0.412456159098652 no 1340 0.436910751145878 2159 4565136
SGTC_1750 st081859 2.357 µM 0.157174834691884 0.413175032365832 no 1341 0.437553530391481 2034 5291695
SGTC_48 0382-0018 55 µM 0.157090399237132 0.413212245640164 no 1342 0.437586801969855 2141 762596
SGTC_230 MPP+ 141.667 µM 0.156671828934308 0.413396733817412 no 1343 0.437751745055869 1989 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2405 ticlatone 3.52 µM 0.154473080957841 0.414366162550788 no 1344 0.438618367364433 2145 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2489 cantharidin 73.42 µM 0.154430582386682 0.414384905345519 no 1345 0.438635120814951 2124 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2428 5615643 7.78 µM 0.152927976793335 0.41504771211017 no 1346 0.439227536557855 2084 2253075
SGTC_1067 clotrimazole 1.36 µM 0.152273073265202 0.415336669092083 no 1347 0.439485780830118 2021 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3021 9087658 49.47 µM 0.151575781610935 0.415644378927854 no 1348 0.439760768070146 2148 25237042
SGTC_2894 9048625 32.47 µM 0.14978118446763 0.416436559324435 no 1349 0.440468627250468 2149 4092861
SGTC_953 1188-0045 9.7 µM 0.148989988498755 0.416785921197097 no 1350 0.440780766406068 2069 6144426
SGTC_1061 3448-9325 110 µM 0.148831052897051 0.416856109015814 no 1351 0.440843473425474 2172 723482
SGTC_1871 st057448 67.3 µM 0.14675729703237 0.417772145929869 no 1352 0.441661795834493 2120 691747
SGTC_2424 5537928 59.2 µM 0.146647367739705 0.417820717324266 no 1353 0.441705181888113 2022 5382802
SGTC_2086 5274770 176.623 µM 0.145758647136303 0.418213437514197 no 1354 0.44205596098759 2036 689278
SGTC_465 cgp-37157 41 µM 0.14533514478229 0.418400609324819 no 1355 0.442223133883644 2158 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3238 9133470 49.47 µM 0.145116406447147 0.418497290525678 no 1356 0.442309482467175 2159 3534688
SGTC_1024 4507-0395 26 µM 0.144997438523499 0.41854987579374 no 1357 0.442356447090282 2028 4201836
SGTC_1843 st055809 45.5 µM 0.144309953730621 0.418853780908516 no 1358 0.442627859320943 2054 16413835
SGTC_1641 st009299 47.1 µM 0.143890153709373 0.419039378839057 no 1359 0.442793605488151 2163 4046054
SGTC_895 0964-0006 13.7 µM 0.143493176169305 0.419214903291309 no 1360 0.442950350055057 2149 6738897
SGTC_696 1560-0013 611 µM 0.141917724586969 0.419911650708415 no 1361 0.443572496913571 2118 1650269
SGTC_3289 9119912 71.43 µM 0.141262945354093 0.420201302461794 no 1362 0.443831110671781 2087 17014829
SGTC_859 0439-0102 54.6 µM 0.138450648867826 0.421445855050399 no 1363 0.444942135198117 2183 610143
SGTC_386 1509-0011 3.07 µM 0.136933372669534 0.422117636755682 no 1364 0.445541729857548 2096 3107280
SGTC_2549 cedrol 20.94 µM 0.134391470881936 0.423243583617937 no 1365 0.446546512852055 2175 6708665 A sedative which affects the nervous system.
SGTC_163 TUB2.036 7.546 µM 0.13329612785585 0.423728964648393 no 1366 0.446979594899215 2184 15992207 YJR013W GPI14
SGTC_1149 3909-7961 23.3 µM 0.13257072040934 0.424050479315683 no 1367 0.447266444858702 2014 735261
SGTC_1907 st060210 83.7 µM 0.132346073740409 0.424150057344463 no 1368 0.447355283140536 2142 688793
SGTC_2642 cholecalciferol 100 µM 0.130962942043277 0.42476325781513 no 1369 0.447902311412493 2173 9821465 A vitamin D precursor, similar to steriods.
SGTC_1951 sophoraflavanone G 9.2 µM 0.130316767548042 0.425049796658567 no 1370 0.44815790730379 1982 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2671 danthron 100 µM 0.128944150838432 0.425658599392075 no 1371 0.448700920469416 2091 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.128423880376132 0.425889403649987 no 1372 0.448906766911477 2193 16725076
SGTC_1917 st066507 28.5 µM 0.128108251137371 0.426029436610455 no 1373 0.449031653196143 2046 3156428
SGTC_2122 5258151 111.688 µM 0.128076965226143 0.426043317514705 no 1374 0.44904403249319 2089 2173356
SGTC_1702 st027038 51 µM 0.127097050637175 0.426478131412617 no 1375 0.449431792891558 2082 5521182
SGTC_1688 st021091 57.6 µM 0.127029932540609 0.426507916755309 no 1376 0.449458353855163 2199 3656366
SGTC_2295 7971645 200 µM 0.12657670092378 0.42670906064275 no 1377 0.449637719280656 2102 2978226 YKL099C UTP11
SGTC_248 streptozotocin 5.23457 mM 0.126550657686016 0.426720619193808 no 1378 0.449648026148274 2192 5300 DNA alkylating agent.
SGTC_2296 7971656 126.45 µM 0.126348893816417 0.426810168485669 no 1379 0.449727877335558 2079 666570
SGTC_775 4577-0580 57.3 µM 0.125138890847252 0.427347285697228 no 1380 0.450206797415596 2129 2006902
SGTC_398 bronopol 33.3 µM 0.124851702649406 0.427474787617204 no 1381 0.450320477393996 2085 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2938 9059746 27.26 µM 0.124756842509954 0.427516903999969 no 1382 0.450358027530134 2125 6471769
SGTC_722 3534-0461 190 µM 0.123538330199438 0.42805797723952 no 1383 0.450840411816159 2071 658262
SGTC_506 n9-isopropylolomoucine 153 µM 0.123161513953464 0.428225327717923 no 1384 0.450989600451875 2213 6610355
SGTC_2221 6807166 181.081 µM 0.122820854397426 0.428376631509434 no 1385 0.45112447993411 2174 674925
SGTC_2192 5915882 198.485 µM 0.122627159808641 0.428462665572335 no 1386 0.451201173169459 2174 2876149
SGTC_2798 7813637 45.45 µM 0.122595310096405 0.428476812705877 no 1387 0.451213784214951 2130 956368
SGTC_2941 9056145 11.23 µM 0.122065194363972 0.42871229513085 no 1388 0.451423693288897 2219 2119517
SGTC_2345 9052315 157.45 µM 0.1218180748197 0.428822076649299 no 1389 0.451521549462818 2066 6469265
SGTC_842 0271-0008 11.1 µM 0.121462820112249 0.428979906274808 no 1390 0.451662230936134 2150 1221709
SGTC_2044 5102272 200 µM 0.120696078826441 0.429320586429379 no 1391 0.45196588246702 2102 592666
SGTC_1888 azatryptophan 97.5 µM 0.120348391190732 0.42947508912136 no 1392 0.452103586010043 2069 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_291 SEC14.278 35.5 µM 0.120195430228026 0.429543064132006 no 1393 0.452164168841443 2167 1068044
SGTC_1178 0988-0033 191 µM 0.118173206728002 0.43044192474699 no 1394 0.45296520955609 2136 5392207
SGTC_2621 lithochol-11-enic acid 100 µM 0.115871674018978 0.431465374297103 no 1395 0.453877122654346 2207 6708711
SGTC_3128 9127691 49.47 µM 0.115105889257945 0.431806007180374 no 1396 0.4541805959907 2121 41316314
SGTC_2403 6032726 181.2 µM 0.114414801433637 0.432113457252583 no 1397 0.454454490599183 2120 2881040
SGTC_2776 terbinafine 19.92 µM 0.113744011980251 0.432411916343167 no 1398 0.454720361192776 2204 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1358 1509-0022 2.48 µM 0.113740584389166 0.432413441504675 no 1399 0.454721719787017 2113 3258434
SGTC_2677 mitomycin C 100 µM 0.113378951618583 0.43257436144738 no 1400 0.454865063137116 2172 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_516 3992-2719 87.3 µM 0.11319882179572 0.432654520085516 no 1401 0.454936464867818 2179 5350887 YDR037W KRS1
SGTC_717 1532-0246 73.2 µM 0.112414934782144 0.433003385812345 no 1402 0.455247207071155 2107 9561992
SGTC_2116 5511452 16.8835 µM 0.112177229045721 0.4331091861146 no 1403 0.455341441892496 2128 870744
SGTC_3248 9135562 49.47 µM 0.111995038375952 0.433190280495579 no 1404 0.455413670311938 2100 17650701
SGTC_1885 st057546 99.9 µM 0.111447633277554 0.433433951363591 no 1405 0.455630694700396 2189 702008
SGTC_1695 st026914 34.495 µM 0.10966008470687 0.434229833108999 no 1406 0.456339478614174 2101 3289191
SGTC_1681 tripelennamine 100 µM 0.108996692371971 0.434525267562886 no 1407 0.456602556905252 2236 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_158 k038-0087 26.446 µM 0.108978534444156 0.4345333545105 no 1408 0.456609757974894 2097 X158
SGTC_2927 9011802 47.9 µM 0.108904763673886 0.434566209882292 no 1409 0.456639014127921 2086 43912568
SGTC_140 0062-0056 502.533 µM 0.108423464255588 0.434780577833417 no 1410 0.456829894532927 2212 3758964
SGTC_3186 9110464 49.47 µM 0.108105539432525 0.434922190213466 no 1411 0.456955987038756 2194 17018021
SGTC_2877 9040724 71.43 µM 0.107809288995326 0.435054155745972 no 1412 0.457073487144057 2221 6463895
SGTC_3318 9139014 38.6185 µM 0.107656075346842 0.435122408005847 no 1413 0.457134256864329 2082 16643984
SGTC_1874 staurosporine 7.6 µM 0.107356068113992 0.435256058168764 no 1414 0.457253252791757 2187 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3179 9107801 49.47 µM 0.105320607437701 0.436163029712401 no 1415 0.458060705771427 2184 4818259
SGTC_1304 1165-0502 251 µM 0.104379321860569 0.436582566648294 no 1416 0.458434165900307 2168 767425
SGTC_427 1354-0053 47.3 µM 0.102792949122267 0.437289784219258 no 1417 0.459063650703274 2168 6813657
SGTC_3173 9105693 49.47 µM 0.102546995104884 0.437399450476723 no 1418 0.459161256364877 2186 17096658
SGTC_551 k048-0028 34.9 µM 0.100608890073859 0.438263782563062 no 1419 0.459930469630255 2209 6836383
SGTC_2477 5967686 25.23 µM 0.0995075228429468 0.438755088213949 no 1420 0.460367657590934 2164 776118
SGTC_2581 avocatin a 64 µM 0.0995047305341161 0.438756333947005 no 1421 0.460368766059645 2147 6710728 A skin care supplement.
SGTC_592 k241-0073 46.5 µM 0.0991164868388111 0.438929547052081 no 1422 0.460522890970829 2222 4230158
SGTC_2139 5578692 56.4705 µM 0.0989416209793489 0.439007566457981 no 1423 0.460592311126398 2247 650991 YMR113W FOL3
SGTC_2364 9055074 200 µM 0.0984599555132811 0.439222482020846 no 1424 0.460783534139293 2131 6470630
SGTC_88 0180-0332 8.668 µM 0.0983983208811812 0.439249984231447 no 1425 0.460808003976899 2243 3101745
SGTC_118 0083-0097 135.343 µM 0.0982151597454741 0.43933171494984 no 1426 0.460880722464073 2223 5207356
SGTC_3263 9137018 49.47 µM 0.0981237469856805 0.439372506396906 no 1427 0.460917015574152 2060 43844957
SGTC_2720 fluspirilene 36.88 µM 0.0980440573213406 0.439408067129845 no 1428 0.460948654593106 2199 3396 An atypical antipsychotic.
SGTC_2857 9024691 58.44 µM 0.0965908151057853 0.440056647726093 no 1429 0.461525675435542 2158 16478292
SGTC_2461 5755302 26.15 µM 0.095832534782002 0.440395131488865 no 1430 0.461826788624596 2236 2788904
SGTC_2308 7584454 197.62 µM 0.0954940455477955 0.44054624154756 no 1431 0.461961209806209 2209 893577
SGTC_594 1487-1584 10.8 µM 0.0953811354068425 0.440596649384921 no 1432 0.462006049760955 2168 5013332
SGTC_2794 7785382 27.27 µM 0.0952005864269397 0.440677256045762 no 1433 0.462077752101391 2286 2205081
SGTC_1756 st041558 35.5 µM 0.0948657754566221 0.440826739961392 no 1434 0.462210720555679 2261 3955792
SGTC_1063 disulfiram 1.84 µM 0.0937390179360379 0.441329868107524 no 1435 0.462658237445439 2250 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3205 9113483 49.47 µM 0.0935674515459829 0.441406485534944 no 1436 0.462726383025985 2219 17018033
SGTC_2490 carminic acid 95.39 µM 0.0918716133409749 0.442163923634048 no 1437 0.463400022663817 2256 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2780 5215298 71.43 µM 0.0914140086754602 0.44236834694 no 1438 0.463581815520968 2269 2834131
SGTC_1194 1488-0194 225 µM 0.090370754933649 0.442834451443726 no 1439 0.463996297880581 2157 1391452
SGTC_1827 berberine 7.24 µM 0.0896634518665748 0.443150505083769 no 1440 0.46427733005065 2115 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2310 7668677 200 µM 0.0881038503896531 0.443847530101088 no 1441 0.464897068057184 2203 2197143
SGTC_581 0958-0271 211 µM 0.0877381975341181 0.444010974755484 no 1442 0.465042379716324 2217 4591145
SGTC_537 1334-0398 209 µM 0.087632407201331 0.444058264183257 no 1443 0.465084422016266 2274 5846986
SGTC_3313 9133968 57.047 µM 0.0873320199294415 0.444192544895817 no 1444 0.465203801510088 2257 1494643
SGTC_103 0844-0104 51.839 µM 0.0870408959977709 0.444322690774223 no 1445 0.465319502568563 2246 5375804
SGTC_3346 9158254 43.5805 µM 0.0866546003412018 0.444495392086814 no 1446 0.465473032143778 2166 17639500
SGTC_3269 9137823 49.47 µM 0.0865008912464593 0.44456411378958 no 1447 0.465534123808317 2112 17682936
SGTC_1286 0929-0070 131 µM 0.0862534518847589 0.444674744798317 no 1448 0.465632470263877 2201 1420408
SGTC_504 lovastatin 124 µM 0.0839980855314072 0.445683324644434 no 1449 0.466528976957634 2091 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_526 4469-0568 170 µM 0.0833620235634261 0.445967829765746 no 1450 0.466781842088452 2235 2901964
SGTC_3270 9137563 49.47 µM 0.08282012166337 0.446210239842562 no 1451 0.466997284659058 2230 17015724
SGTC_1768 st044301 37.178 µM 0.0827592229287681 0.446237483055439 no 1452 0.467021496620801 2251 3931349
SGTC_726 3448-4391 34.2 µM 0.0824398379962991 0.446380364917595 no 1453 0.467148478854119 2210 1356692
SGTC_2702 st077768 96.8 µM 0.0817149150645451 0.446704696374256 no 1454 0.467436708759817 2180 6484119
SGTC_639 0833-0042 114 µM 0.0813176683053194 0.446882440223049 no 1455 0.467594661623078 2185 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.081180009538481 0.446944036669483 no 1456 0.467649398557416 2164 4213774
SGTC_572 0960-0087 17.7 µM 0.081096203519365 0.446981536927424 no 1457 0.467682722448924 2221 6796365
SGTC_2065 5221596 34.26 µM 0.080331403723318 0.447323779907423 no 1458 0.467986841177168 2213 788581
SGTC_3148 9097893 49.47 µM 0.0800132463289725 0.447466164859069 no 1459 0.468113360351555 2185 17174100
SGTC_908 3448-7491 47.7 µM 0.0792522338531863 0.447806768138789 no 1460 0.468415999300642 2215 1203031
SGTC_1014 4130-3005 69.3 µM 0.0791913212655766 0.447834032206464 no 1461 0.46844022377037 2229 743608
SGTC_777 1315-0167 517 µM 0.0780697733759629 0.448336073468766 no 1462 0.468886275569876 2089 4221767
SGTC_212 3807-4682 38.772 µM 0.0780537588324033 0.448343242699765 no 1463 0.468892645012266 2230 3125501 YBL034C STU1
SGTC_729 4092-0585 94.1 µM 0.0765464144523382 0.449018110788073 no 1464 0.46949219443668 2205 2169061
SGTC_1893 st059353 36.1 µM 0.0764080093826516 0.449080084917626 no 1465 0.469547248835024 2122 3112488
SGTC_2598 perillyl alcohol 100 µM 0.0763564195769631 0.449103185786044 no 1466 0.469567770238924 2207 10819 An apoptosis inducer.
SGTC_206 4546-0025 72.014 µM 0.0760060823732934 0.449260064238801 no 1467 0.469707129582099 2170 6620745 YIL048W NEO1
SGTC_979 1426-2828 121 µM 0.0754542408930664 0.449507190919744 no 1468 0.469926652087382 2217 747872
SGTC_3291 9121177 71.43 µM 0.0745885054978858 0.449894925588438 no 1469 0.470271059965124 2196 17015612
SGTC_881 0833-0569 170 µM 0.0741830784260451 0.450076519630185 no 1470 0.470432355103892 2078 5418700
SGTC_2513 baicalein 25.65 µM 0.0734691949553369 0.450396299156478 no 1471 0.47071637833633 2205 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2069 5228469 200 µM 0.0734198442489577 0.450418406681683 no 1472 0.470736013391492 2207 2835210
SGTC_3112 9123419 49.47 µM 0.0728482182197894 0.45067448790503 no 1473 0.470963450133449 2295 17015854
SGTC_563 tetrahydrosecaminediol 614 µM 0.0724519066603593 0.450852042525709 no 1474 0.471121138877017 2275 334274 A psychoactive constituent of the cannabis plant.
SGTC_1945 st075991 56.6 µM 0.0722274269846562 0.450952617774684 no 1475 0.471210459296441 2108 1084980
SGTC_3272 9137413 49.47 µM 0.0714603731799806 0.451296310152084 no 1476 0.471515680758379 2293 17614870
SGTC_100 0086-0128 49.5915 µM 0.0714311878656042 0.45130938788454 no 1477 0.471527294335643 2219 93297
SGTC_404 fumagillin 50 µM 0.0710714083954349 0.451470606851261 no 1478 0.471670461703228 2166 12015870 A methionine aminopeptidase binder.
SGTC_3139 9095020 49.47 µM 0.0705834218184893 0.451689288845601 no 1479 0.471864652486504 2290 25236292
SGTC_2151 5563267 85.4165 µM 0.0700214740615055 0.45194113330747 no 1480 0.472088283878078 2171 5310824
SGTC_1054 3429-0080 167 µM 0.0694187380192295 0.452211279083886 no 1481 0.472328157057641 2265 1162877
SGTC_637 1181-0519 7.26 µM 0.0687379531947775 0.452516432860656 no 1482 0.472599103676992 2263 6252091 YGR060W ERG25
SGTC_2816 7982706 58.44 µM 0.0680170337890416 0.452839607065168 no 1483 0.472886037341305 2220 2981853
SGTC_580 1123-0028 41 µM 0.0677211681868611 0.452972246937257 no 1484 0.473003799108339 2275 1677248 YPR107C YTH1
SGTC_1386 3228-0095 33.8 µM 0.0676308946864822 0.453012718606724 no 1485 0.473039730646106 2261 870181
SGTC_902 1120-0002 2.07 µM 0.0669578329053761 0.453314482914145 no 1486 0.47330763614635 2275 3280475
SGTC_892 0929-0076 29 µM 0.0669079375991812 0.453336854332068 no 1487 0.473327496955396 2281 5751038
SGTC_1978 st071761 42 µM 0.0668570079394218 0.45335968967291 no 1488 0.473347769556892 2124 5147680
SGTC_2078 5212016 200 µM 0.0663426109017685 0.453590338598753 no 1489 0.473552529667665 2307 1899708
SGTC_1470 k295-0292 231 µM 0.0662595313523504 0.45362759185608 no 1490 0.473585600844946 2276 5045612
SGTC_251 melphalan 456.522 µM 0.0661611717664364 0.453671697280502 no 1491 0.473624754726707 2225 460612 A DNA alkylator.
SGTC_710 3448-4187 58 µM 0.0658900645491386 0.45379326743102 no 1492 0.473732675367661 2280 3946412
SGTC_16 erodoxin 22.806 µM 0.065323788297696 0.454047211507889 no 1493 0.473958101234556 2272 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1168 k815-0004 80.5 µM 0.0649161398896643 0.454230031266972 no 1494 0.474120384962912 2265 642433
SGTC_1320 1313-0481 95.3 µM 0.0644801578125587 0.454425568674125 no 1495 0.474293953000261 2260 6813365 YLR208W SEC13
SGTC_27 0485-0001 32.618 µM 0.0643646377205443 0.454477381141463 no 1496 0.474339943314544 2280 2054479
SGTC_2374 9071832 200 µM 0.0641733960082172 0.45456315757597 no 1497 0.474416080314579 2286 17381698
SGTC_3201 9113999 49.47 µM 0.063773064221362 0.45474272271345 no 1498 0.474575463112602 2262 16649224
SGTC_143 4032-1194 15.74 µM 0.0635654093637279 0.454835868033295 no 1499 0.474658137673058 2275 1806963
SGTC_457 grayanotoxin iii 135 µM 0.0627663414419332 0.455194319739022 no 1500 0.474976284318938 2230 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_299 1273-0059 1.44 µM 0.0620831275367279 0.45550082974943 no 1501 0.475248316675999 2295 2848077
SGTC_1766 st045414 44.774 µM 0.0613834248699429 0.455814764561807 no 1502 0.475526926251507 2295 253960
SGTC_273 hydroxyurea 18.1 mM 0.0611792724091452 0.455906366625743 no 1503 0.475608218513597 2310 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2159 5658611 73.75 µM 0.0605208744338012 0.456201802047909 no 1504 0.475870395463558 2305 793844
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0602650441726958 0.456316604387941 no 1505 0.475972271015698 2255 115019
SGTC_1643 st009866 20.2 µM 0.059189733602505 0.456799183510826 no 1506 0.476400493352684 2297 3156273 YOR207C RET1
SGTC_2916 7875993 68.79 µM 0.0588577939204998 0.456948164689407 no 1507 0.476532687655537 2312 1299250
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0588237782546071 0.456963431943819 no 1508 0.476546234471395 2320 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1073 triclabendazole 3.09 µM 0.0578664265960173 0.457393146144708 no 1509 0.47692751299325 2218 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_104 0074-0074 590.992 µM 0.057836827799255 0.457406432574734 no 1510 0.476939301461327 2319 3943124
SGTC_424 splitomicin 100 mM 0.0577449584564866 0.45744767156752 no 1511 0.476975890874943 2119 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2433 5607874 27.82 µM 0.0572113668025963 0.457687203196254 no 1512 0.477188411796674 2289 2252428
SGTC_1554 st069299 38.7 µM 0.0572059317995843 0.457689643072114 no 1513 0.477190576503911 2247 24207999
SGTC_2205 7238770 200 µM 0.0569195472493259 0.457818208777859 no 1514 0.477304641551012 2308 279867
SGTC_2626 ethyl orsellinate 100 µM 0.0568727407532252 0.457839221889363 no 1515 0.477323284441754 2276 75653 A natural product.
SGTC_2492 derrusnin 100 µM 0.0563884706059273 0.458056634998951 no 1516 0.477516170733026 2271 1715307 Part of coumarin class of compounds.
SGTC_2737 bleomycin 30.5 nM 0.0554718843264901 0.458468170764337 no 1517 0.477881264253964 2301 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3152 9099253 49.47 µM 0.0528486345604388 0.459646221615011 no 1518 0.478926255420109 2269 25236131
SGTC_896 0964-0007 44.5 µM 0.0527122305592812 0.459707487801854 no 1519 0.478980596998925 2324 6756758
SGTC_2964 9083345 53.42 µM 0.0519992876082662 0.460027723387922 no 1520 0.479264630526925 2266 17741579
SGTC_2597 laccaic acid a 100 µM 0.0519386272928012 0.460054971637093 no 1521 0.479288797834257 2266 5491415 A textile dye.
SGTC_335 4077-0256 27.6 µM 0.0499126278669123 0.460965145382459 no 1522 0.480096007132316 2302 3121989
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0495027617654015 0.461149301441518 no 1523 0.480259318164755 2301 616764
SGTC_950 1165-0508 94.1 µM 0.0482419902299488 0.461715828057058 no 1524 0.480761692881244 2261 6148369
SGTC_2558 carylophyllene oxide 100 µM 0.0478831647547953 0.461877080230859 no 1525 0.480904678289432 2335 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2469 5655019 90.81 µM 0.0446508129596301 0.46332994246252 no 1526 0.482192820067173 2313 2788239
SGTC_3310 9130229 44.1445 µM 0.0441872890995778 0.463538325541954 no 1527 0.482377556993556 2311 7761258
SGTC_3017 9080681 49.47 µM 0.0440712245685239 0.463590505404644 no 1528 0.482423814979087 2261 16451914
SGTC_2836 9010338 19.48 µM 0.0439010231928545 0.463667025042231 no 1529 0.482491649849446 2296 2994051
SGTC_1809 st050081 57.6 µM 0.043369439562008 0.463906024624403 no 1530 0.482703519233631 2295 5036894
SGTC_669 0108-0021 26.2 µM 0.0428895260617534 0.464121804547178 no 1531 0.48289479903045 2356 17201
SGTC_2166 5933061 31.504 µM 0.0420184277135595 0.464513496910883 no 1532 0.483242003949256 2287 2877375
SGTC_2248 tofa 1.1 µM 0.0416462871646252 0.464680841693584 no 1533 0.483390336703661 2309 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_287 k060-0039 29.6 µM 0.0412363716740996 0.464865180404795 no 1534 0.483553728959219 2333 5861974
SGTC_2366 9070441 60.58 µM 0.0394887662034042 0.465651161495681 no 1535 0.484250354901648 2330 6837235
SGTC_2231 micatex 6.853 µM 0.0391774295246331 0.465791198522127 no 1536 0.484374464224301 2277 20737 An antifungal of unknown mechanism.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0390097660714738 0.46586661410824 no 1537 0.48444130117128 2325 688798
SGTC_2200 6600604 21.907 µM 0.0370065355650991 0.466767767993026 no 1538 0.485239897342041 2324 2904777
SGTC_753 1322-0200 289 µM 0.036708811048678 0.466901714116823 no 1539 0.485358591589368 2299 5403907
SGTC_1815 st051655 58.2 µM 0.0364328053523372 0.467025892302004 no 1540 0.485468628323428 2347 5984156
SGTC_2874 9043904 71.43 µM 0.0357084144982235 0.467351819439302 no 1541 0.48575743051657 2219 4463428
SGTC_972 1319-0219 195 µM 0.0353439843379502 0.467515796777648 no 1542 0.485902725396895 2296 23903702
SGTC_1711 st032263 62.8 µM 0.0351979148875276 0.467581523072717 no 1543 0.48596096244062 2276 3958979
SGTC_1846 st056244 14.8 µM 0.0351731617352958 0.467592661238723 no 1544 0.485970831408727 2278 5393182
SGTC_2191 5911152 200 µM 0.0347236449782362 0.467794934519554 no 1545 0.486150053164022 2345 2875902
SGTC_2046 4110841 106 µM 0.0339483731072127 0.468143810399874 no 1546 0.486459159618419 2352 44119630 YMR134W ERG29
SGTC_2021 4019055 173 µM 0.0336146036309633 0.468294015737578 no 1547 0.486592238418089 2327 44827708 YER133W GLC7
SGTC_867 0518-0118 155 µM 0.0331470979152319 0.468504413602801 no 1548 0.486778642330604 2345 6848158
SGTC_1796 st049173 110.4 µM 0.0331403793534723 0.468507437311488 no 1549 0.486781321177183 2346 94134
SGTC_1976 st070609 63.5 µM 0.0331206139331775 0.468516332808165 no 1550 0.486789202112666 2341 682556
SGTC_1037 k284-1091 78.7 µM 0.0330523576971834 0.468547051887234 no 1551 0.486816417510463 2331 3334711
SGTC_3129 9127257 49.47 µM 0.0317116731979135 0.469150471752605 no 1552 0.487350992851903 2277 837894
SGTC_558 k064-0027 21.3 µM 0.0316327204879847 0.469186009281465 no 1553 0.487382474631949 2316 5088526
SGTC_2906 7926292 26.41 µM 0.0312850885926461 0.469342485338752 no 1554 0.487521091083581 2300 2966319
SGTC_816 0325-0417 81.3 µM 0.0308934205339939 0.469518788624144 no 1555 0.487677268536807 2299 68101
SGTC_1092 toremifene 6.32 µM 0.0308862628891386 0.469522010582372 no 1556 0.487680122661965 2352 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2094 5332512 191.667 µM 0.0303557335011375 0.469760829806801 no 1557 0.48789167405999 2348 755774
SGTC_2628 lathosterol 100 µM 0.0293399966474675 0.470218096750444 no 1558 0.488296713955068 2326 6710616
SGTC_1922 5578187 25 µM 0.0292347346974818 0.470265486093216 no 1559 0.488338689391343 2353 1350412
SGTC_2208 7283366 200 µM 0.0287847839657888 0.470468060416861 no 1560 0.48851811824429 2350 898663
SGTC_1458 k015-0034 6.33 µM 0.0279598418815714 0.47083948108144 no 1561 0.488847090075381 2320 3598957
SGTC_2329 6138490 200 µM 0.0271976586811639 0.471182667835794 no 1562 0.489151041559254 2279 720019
SGTC_828 2074-0507 139 µM 0.0266385911136072 0.471434411727809 no 1563 0.48937399645708 2351 X828
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.026565637549091 0.47146726300951 no 1564 0.489403090422144 2374 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1121 fusaric acid 630.51 nM 0.0262702061636508 0.471600298925865 no 1565 0.48952090937184 2323 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_853 0419-0306 21 µM 0.0258581655447608 0.471785850517418 no 1566 0.489685233969033 2334 762713
SGTC_1783 st039459 87.517 µM 0.0255893868225781 0.471906891206841 no 1567 0.489792425694133 2349 729761
SGTC_1668 st014914 51.6 µM 0.0245414942075978 0.472378819474301 no 1568 0.490210343040048 2353 2839556
SGTC_3214 9129694 49.47 µM 0.0236232557500125 0.472792388677297 no 1569 0.490576560959992 2352 17158655
SGTC_429 1112-0049 25.5 µM 0.0224196764846099 0.473334518053854 no 1570 0.491056592365535 2343 2836170
SGTC_2211 7117706 200 µM 0.0223754658206286 0.473354432852759 no 1571 0.491074225445257 2362 822771
SGTC_1075 aripiprazole 15.2 µM 0.0217918209476874 0.473617343299909 no 1572 0.491307009288726 2365 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2189 6047310 154.431 µM 0.0217382949448763 0.473641455363197 no 1573 0.491328358017111 2348 711535
SGTC_1752 st044819 83.042 µM 0.0199857553324379 0.474430981416379 no 1574 0.492027367947622 2359 441209 YML126C ERG13
SGTC_2751 anetholtrithion 17.25 µM 0.0197992477596272 0.47451500978541 no 1575 0.492101758983768 2358 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1239 0337-0584 35.4 µM 0.0193053043920746 0.474737554503739 no 1576 0.492298776212601 2364 914301 YML130C ERO1
SGTC_274 sirtinol 40.1 µM 0.0185015925247545 0.475099681317159 no 1577 0.492619353566377 2353 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1969 st069479 40.1 µM 0.0171078130739592 0.475727722272298 no 1578 0.493175302946832 2378 3895485
SGTC_403 arphamenine a 50 µM 0.0169932816021354 0.475779333179504 no 1579 0.493220987752102 2376 5487158 An arginine aminopeptidase inhibitor.
SGTC_1808 st050063 61.5 µM 0.0169736512861267 0.475788179159362 no 1580 0.493228817985785 2371 4011993
SGTC_2184 6075246 200 µM 0.0168737569720469 0.475833194569063 no 1581 0.493268664344585 2352 2267320
SGTC_1151 3909-8316 15.3 µM 0.0152049307590843 0.47658526348454 no 1582 0.49393434397028 2321 800431
SGTC_829 1635-0120 117 µM 0.0151487950276109 0.476610562933522 no 1583 0.493956736307961 2376 285054
SGTC_830 4076-0286 57.8 µM 0.0150447404063326 0.476657458885644 no 1584 0.493998243365585 2358 6866659
SGTC_224 benfluorex 43.875 µM 0.0145380487537459 0.476885822284424 no 1585 0.494200361975262 2382 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_400 oxethazaine 37.5 µM 0.0119335064327331 0.478059794675316 no 1586 0.495239332724116 2321 4621 A local anesthetic.
SGTC_2848 9016370 25.97 µM 0.0118400321258178 0.478101930919899 no 1587 0.495276620942845 2383 7894410
SGTC_181 1447-1644 8.07 µM 0.0109185628346565 0.478517322852796 no 1588 0.495644210190132 2379 534600
SGTC_3253 9135987 49.47 µM 0.010857894849485 0.478544672381338 no 1589 0.495668411779845 2380 4182430
SGTC_2752 diclazuril 33.15 µM 0.00960521920586324 0.479109409229518 no 1590 0.496168130867873 2388 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2038 4100038 30.985 µM 0.00803469528280164 0.479817498983886 no 1591 0.496794654829138 2382 3596803
SGTC_1214 0358-0031 63.7 µM 0.00711528123110641 0.480232057659898 no 1592 0.49716143743141 2387 4301366
SGTC_344 k064-0035 6.43 µM 0.00688283026476268 0.480336871910162 no 1593 0.497254169678441 2389 5088750
SGTC_2034 5197015 53.07 µM 0.00683461922793668 0.480358610874654 no 1594 0.497273402647026 2383 780676
SGTC_974 1326-0144 138 µM 0.00682566582975153 0.480362648081241 no 1595 0.497276974452801 2387 5411856
SGTC_686 1319-0111 510 µM 0.00585157533424014 0.480801890411877 no 1596 0.497665572514388 2389 4562600
SGTC_3316 9136639 10.545 µM 0.00528479735780954 0.481057475866317 no 1597 0.497891680704525 2360 4903665
SGTC_601 0986-0029 62.9 µM 0.00326245446279025 0.481969503155396 no 1598 0.498698471285736 2399 24747981
SGTC_1378 2093-0007 380 nM 0.00310356278014955 0.482041163487019 no 1599 0.498761859574768 2397 3618014
SGTC_623 k072-0108 16.9 µM 0.00297204168897685 0.48210048008943 no 1600 0.498814328656664 2392 5382803
SGTC_2606 farnesol 9.78 µM 0.00135180249667254 0.482831247339353 no 1601 0.499460708993572 2402 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1835 st008666 49.2 µM 0.00105452906925361 0.482965331214351 no 1602 0.499579303846334 2400 690455
SGTC_1653 st012112 65 µM 0.000901587153180935 0.483034315746036 no 1603 0.499640318813858 2398 720429
SGTC_3182 9108849 49.47 µM 0.00070915681997173 0.483121112270325 no 1604 0.499717087384791 2401 17133045
SGTC_3043 9092303 49.47 µM 0.000496991802668651 0.483216811135253 no 1605 0.499801728965065 2405 25236084
SGTC_2421 5690543 90.72 µM 0 0.483440987359294 no 1606 0.5 2385 3397993
SGTC_3166 9102297 49.47 µM -0.000701636582335417 0.483757480830131 no 1607 0.499720087524797 2407 25237072
SGTC_2517 totarol 10 µM -0.00212607615688996 0.484400046762001 no 1608 0.499151818968655 2411 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_201 4262-0159 12.803 µM -0.00218785410777884 0.484427915778101 no 1609 0.499127173189385 2408 1341029
SGTC_1448 4255-0083 152 µM -0.00283936903330249 0.484721829127047 no 1610 0.498867257164985 2411 5399660
SGTC_2690 usnic acid 100 µM -0.00320198834495625 0.48488541863432 no 1611 0.498722593650662 2415 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3281 9140613 49.47 µM -0.00358202835770968 0.485056869923011 no 1612 0.498570980494454 2413 16013766
SGTC_3228 9131799 49.47 µM -0.00392981433990109 0.485213772546817 no 1613 0.498432234940968 2420 17015818
SGTC_1953 st076800 12.1 µM -0.00475040159174051 0.485583987103452 no 1614 0.498104871083851 2424 297591
SGTC_1896 st058441 89 µM -0.00541863364426561 0.485885474577169 no 1615 0.49783828851585 2415 688759
SGTC_3250 9135583 49.47 µM -0.00566471855968357 0.48599650319897 no 1616 0.497740116346222 2421 7699353
SGTC_3147 9097027 49.47 µM -0.00595949964085597 0.486129503990973 no 1617 0.4976225176962 2427 25236841
SGTC_682 0kpi-0099 17 µM -0.00616209447313243 0.486220912628903 no 1618 0.497541695536396 2425 1714895 YML126C ERG13
SGTC_45 0kpi-0036 14.9 µM -0.0061694069059781 0.486224211934552 no 1619 0.497538778353213 2399 2795021
SGTC_727 3032-0951 202 µM -0.0062521643894585 0.48626155145189 no 1620 0.497505763530803 2426 3652836
SGTC_706 4262-0057 46.9 µM -0.00666097070427574 0.486446003365531 no 1621 0.497342676807818 2417 883298
SGTC_868 0527-0199 213 µM -0.00905285419292687 0.487525269282897 no 1622 0.496388483034011 2436 2849450
SGTC_3344 9148862 3.898 µM -0.00925987244310127 0.487618684488571 no 1623 0.496305898163338 2430 4905352
SGTC_3116 9124943 49.47 µM -0.00962604285505725 0.48778391739922 no 1624 0.496159823817823 2426 41905195 YPL160W CDC60
SGTC_3126 9127922 49.47 µM -0.010260211357663 0.48807008830368 no 1625 0.495906839699518 2446 45595682
SGTC_451 chloral hydrate 100 µM -0.0113489856697025 0.488561416020212 no 1626 0.495472506966682 2436 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1772 st048439 82.2 µM -0.0121215604404441 0.488910063950033 no 1627 0.495164315455806 2438 2927068 YDL195W SEC31
SGTC_2937 9044753 11.33 µM -0.0122281091794471 0.488958147989359 no 1628 0.495121811809116 2431 6465530 YGL099W LSG1
SGTC_668 1682-0499 62.6 µM -0.0124724289556289 0.489068406883799 no 1629 0.495024349753887 2441 682214
SGTC_492 tmb-8 126 µM -0.014571331796827 0.490015652762198 no 1630 0.494187085368483 2431 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_416 estradiol valerate 100 µM -0.0152143907264152 0.490305880152581 no 1631 0.49393057042584 2450 13791 A steroid.
SGTC_3044 9093193 49.47 µM -0.0170158039584807 0.491118926508234 no 1632 0.493212003930851 2458 25236277
SGTC_2959 9079155 11 µM -0.0171489160039571 0.491179006546244 no 1633 0.493158907655417 2465 16189457
SGTC_2835 9006588 71.43 µM -0.0179448992093755 0.491538277194587 no 1634 0.492841405190976 2497 2345538
SGTC_684 1140-0066 328 µM -0.0192438292044935 0.492124569778674 no 1635 0.492323296708904 2445 6813534
SGTC_40 0327-0103 19.753 µM -0.0195201321533834 0.492249285719251 no 1636 0.492213088483163 2451 409036
SGTC_823 0417-1665 178 µM -0.0204127128237151 0.49265217845585 no 1637 0.491857071298542 2471 3429856
SGTC_1257 0669-0121 16 µM -0.0211256114422264 0.49297397177773 no 1638 0.491572727237668 2475 4307855
SGTC_2907 7721985 69.9 µM -0.0211521559010847 0.492985953696675 no 1639 0.491562139896473 2456 3267881
SGTC_489 paxilline 115 µM -0.0223849402836894 0.493542427757845 no 1640 0.491070446627832 2475 105008 A toxic potassium channel blocker.
SGTC_2679 rapamycin 1 nM -0.0231107280053831 0.4938700514507 no 1641 0.490780974130886 2454 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_493 zm226600 134 µM -0.0232099765890915 0.493914853013703 no 1642 0.490741390292438 2469 5240098 A potassium channel opener. YCR052W RSC6
SGTC_928 2764-0428 58.7 µM -0.0234825310508732 0.494037886556873 no 1643 0.490632686422684 2532 662578
SGTC_312 4092-0653 6.84 µM -0.023559517055984 0.494072638837415 no 1644 0.49060198194488 2509 1148278
SGTC_1616 st002734 56.1 µM -0.0242087447765709 0.494365708721983 no 1645 0.490343051426287 2467 4026101
SGTC_1373 2887-0003 58.5 µM -0.0250145402330085 0.494729459542192 no 1646 0.490021682904542 2484 776948
SGTC_2658 polymyxin b sulfate 77.05 µM -0.0250233407802341 0.494733432295058 no 1647 0.490018173092814 2468 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2060 5238662 140 µM -0.0253247784491308 0.494869507937208 no 1648 0.489897954961391 2478 790130
SGTC_957 1187-1561 14.1 µM -0.0255302863075318 0.494962279080746 no 1649 0.489815995687917 2438 1538454
SGTC_501 nsc-95397 161 µM -0.0255843230762012 0.494986672611 no 1650 0.489794445175488 2457 262093
SGTC_3020 9089140 49.47 µM -0.0256741143501768 0.495027206648284 no 1651 0.489758635402778 2454 17217859
SGTC_3286 9117135 37.221 µM -0.025707079129243 0.495042087790777 no 1652 0.489745488697818 2461 3438150
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0260293465521401 0.495187567889571 no 1653 0.48961696560652 2492 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1001 4048-4355 44.4 µM -0.0268593352644995 0.495562249802427 no 1654 0.489285963781949 2453 21824233
SGTC_19 0279-0214 38.434 µM -0.027087752814517 0.495665365067821 no 1655 0.489194871507986 2463 3566274 YBR002C RER2
SGTC_3231 9132313 49.47 µM -0.027199099935029 0.495715630960097 no 1656 0.489150466794781 2475 4905967
SGTC_1973 st070275 50.2 µM -0.0280117575417204 0.496082494362044 no 1657 0.488826386832564 2441 17118334
SGTC_1437 4092-1038 11.6 µM -0.0282135108803655 0.496173573732412 no 1658 0.488745930695041 2458 3977136
SGTC_68 0986-0284 82.829 µM -0.028589846249009 0.496343466808049 no 1659 0.488595855147593 2606 423278 YIL048W NEO1
SGTC_595 3909-8003 73.7 µM -0.0286579340452964 0.496374204477395 no 1660 0.488568703172333 2474 699517
SGTC_175 3793-3120 23.7 µM -0.028892320320938 0.496480016375589 no 1661 0.488475235281337 2469 5322297
SGTC_2989 9073649 71.4286 µM -0.0291186361358375 0.496582185160848 no 1662 0.488384986306262 2457 21367202
SGTC_2239 6685329 187.64 µM -0.0293727682588446 0.496696911702216 no 1663 0.48828364560604 2574 805680
SGTC_1280 0880-0253 10.1 µM -0.030049655011608 0.497002489790158 no 1664 0.488013726029341 2464 6836607
SGTC_2376 9072922 81.32 µM -0.0317454411697042 0.497768053674273 no 1665 0.487337528159401 2552 17087968
SGTC_2022 5136654 200 µM -0.0319670972349923 0.497868121132572 no 1666 0.487249145041373 2507 1713771
SGTC_1994 st072947 40.9 µM -0.0328029562178568 0.498245473945637 no 1667 0.486915860380987 2549 5286565 YDL195W SEC31
SGTC_544 k015-0020 52.4 µM -0.0341176922148498 0.498839021282084 no 1668 0.486391650175222 2500 3008304
SGTC_2878 9043973 25.97 µM -0.0345887301934535 0.499051675571787 no 1669 0.486203844063365 2579 6465167
SGTC_1419 3993-2473 62.6 µM -0.0352938122487781 0.499369991628766 no 1670 0.485922728684372 2481 704026
SGTC_1743 st037606 46.3785 µM -0.0353185314905519 0.49938115137603 no 1671 0.485912873278112 2496 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_652 0437-0092 114 µM -0.0357406867279028 0.499571737619229 no 1672 0.485744563972711 2471 3091274
SGTC_432 NS 1619 61.3 µM -0.0357778047988277 0.49958849495233 no 1673 0.485729765469476 2600 4552 A K+/calcium channel activator.
SGTC_178 4092-0806 87.505 µM -0.0360830129455772 0.499726284319465 no 1674 0.485608083606537 2476 2169044
SGTC_2589 lobaric acid 100 µM -0.0365249596880522 0.499925805790097 no 1675 0.48543188851573 2485 73157 A novel microtubule depolymerizer.
SGTC_3091 9116372 49.47 µM -0.0366190314692411 0.499968275481871 no 1676 0.485394384394308 2589 17169793
SGTC_480 am 92016 50 µM -0.0366893023324968 0.5 no 1677 0.4853663692018 2515 2129 K+ channel blocker.
SGTC_787 4152-0075 138 µM -0.0370795998463442 0.49982379609997 no 1678 0.485210768902789 2505 9566539
SGTC_2687 chenodiol 100 µM -0.0371580294994772 0.499788388214749 no 1679 0.485179501545729 2490 5702181 A cholesterol synthesis inhibitor.
SGTC_1204 4049-0315 18.3 µM -0.0372723774221636 0.49973676465504 no 1680 0.485133914903748 2656 588402
SGTC_475 α-linolenic acid 10 µM -0.0372929469087225 0.49972747834671 no 1681 0.485125714567076 2504 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3109 9122853 49.47 µM -0.0375078009360225 0.499630480274509 no 1682 0.485040060138782 2527 1234709
SGTC_1678 st019265 80.2 µM -0.0379488251918845 0.499431375388781 no 1683 0.484864242094352 2472 5367020
SGTC_1735 st034310 56.75 µM -0.0387948665683557 0.499049421843709 no 1684 0.484526968820123 2654 871153
SGTC_430 0958-0115 16.4 µM -0.0390274668213527 0.498944412352404 no 1685 0.484434244967171 2520 6833180
SGTC_2701 st077767 14.721 µM -0.0396466628017204 0.498664871094005 no 1686 0.484187412563393 2500 5721188
SGTC_1246 0422-0085 105 µM -0.0396810162145672 0.49864936197337 no 1687 0.484173718310808 2475 264295
SGTC_3160 9100216 49.47 µM -0.0403237312367814 0.498359203582029 no 1688 0.483917517185856 2473 17191039
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0409566003482889 0.498073491046363 no 1689 0.483665247356901 2514 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_762 1165-0429 115 µM -0.0411370141018272 0.497992042355699 no 1690 0.483593333290132 2447 5967793
SGTC_210 3551-0445 56.827 µM -0.0420296875897123 0.497589041745735 no 1691 0.483237515873356 2544 2865180 YOR207C RET1
SGTC_237 nikkomycin 200 µM -0.0426124415960451 0.497325956685798 no 1692 0.483005238770176 2492 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1472 k841-0093 193 µM -0.0427229873941816 0.497276050768081 no 1693 0.482961177503175 2557 X1472
SGTC_525 k781-2675 26.7 µM -0.0428052764002069 0.49723890141118 no 1694 0.482928378943711 2485 3651118 YDL195W SEC31
SGTC_1801 st050089 28.441 µM -0.0441105232319214 0.496649651380098 no 1695 0.48240815231225 2472 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1408 3909-7976 48.8 µM -0.0442424467604931 0.496590095257437 no 1696 0.482355573769139 2503 24152374
SGTC_1607 st000305 50.6 µM -0.0458353339281134 0.495871001838721 no 1697 0.481720747996308 2473 5457690
SGTC_1390 3413-2614 145 µM -0.0466312508213994 0.495511697779202 no 1698 0.481403562280452 2510 3421432
SGTC_1468 k284-1086 134 µM -0.0471620772370561 0.495272066617832 no 1699 0.481192025925763 2498 15996457
SGTC_2781 5567276 71.43 µM -0.0476736900548008 0.49504111067143 no 1700 0.480988151274236 2545 2853274
SGTC_1479 0549-0158 134 µM -0.0485422141557552 0.494649039107684 no 1701 0.480642061022817 2505 5440202
SGTC_1032 k061-1018 98.7 µM -0.0491160838695376 0.494389984058811 no 1702 0.480413392901315 2666 4005393
SGTC_397 arbidol 50 µM -0.0508904343279438 0.493589025986447 no 1703 0.479706413967411 2620 131410 A RNA synthesis inhibitor.
SGTC_338 4055-0136 114 µM -0.0517538895458469 0.493199263529957 no 1704 0.479362398545068 2488 2900563
SGTC_804 1595-0054 20.9 µM -0.0520343113673772 0.493072682897474 no 1705 0.479250676958788 2508 761523 Stimulates phospholipase C.
SGTC_70 0141-0289 43.283 µM -0.052970715461748 0.492650001151291 no 1706 0.478877620310026 2603 352408
SGTC_3028 9087778 49.47 µM -0.0535081669217883 0.492407405608398 no 1707 0.478663511855227 2511 17217395
SGTC_1631 benzylvanillin 81.9 µM -0.054684927705171 0.491876247716993 no 1708 0.478194738671356 2591 75506
SGTC_1588 farnesol 29.9 µM -0.054709749296621 0.491865044075848 no 1709 0.478184851090954 2512 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_419 nsc-638432 893 µM -0.0551044499097708 0.491686890209866 no 1710 0.478027625509027 2549 368090
SGTC_674 0498-0004 451 µM -0.0552942483184289 0.491601222524143 no 1711 0.477952022167443 2518 4231473
SGTC_490 phenamil 164 µM -0.0566646149132971 0.490982703604291 no 1712 0.477406180956535 2548 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1064 honokiol 6.76 µM -0.0577825159309949 0.49047815174215 no 1713 0.476960932586527 2559 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1671 st016596 74.5 µM -0.0579092467448355 0.490420954182562 no 1714 0.476910458823662 2539 2829167
SGTC_990 3985-0011 41.3 µM -0.0584170080239946 0.490191787705478 no 1715 0.476708233731304 2566 5399565 YGL099W LSG1
SGTC_2724 maprotiline 69.64 µM -0.0592865715724193 0.489799337584675 no 1716 0.476361928316964 2493 4011 A tricyclic antidepressant.
SGTC_1333 1482-0047 286 µM -0.0595854275927136 0.489664460593416 no 1717 0.476242912420967 2509 3811116
SGTC_3240 9133527 49.47 µM -0.0609221492995376 0.489061198148269 no 1718 0.475710604808551 2499 17617455
SGTC_646 4092-0839 27.3 µM -0.0613540725444401 0.488866276490378 no 1719 0.475538614105493 2555 877796
SGTC_2688 kanamycin b 96.69 µM -0.0614210721352851 0.488836040634625 no 1720 0.475511935451702 2541 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2434 5670830 169.91 µM -0.0615982482803122 0.488756084152038 no 1721 0.475441385982559 2579 1549830
SGTC_2998 9066762 71.4286 µM -0.0616027302973386 0.488754061502317 no 1722 0.475439601305766 2559 4945196
SGTC_2385 9074692 200 µM -0.0619649715196034 0.488590589834029 no 1723 0.475295363525589 2523 17046906
SGTC_2138 5575593 77.673 µM -0.0639831980326432 0.487679843494567 no 1724 0.474491802709737 2519 762213
SGTC_2399 5884133 200 µM -0.0640352615728814 0.487656350093803 no 1725 0.474471074868658 2549 722445
SGTC_2370 9071495 200 µM -0.0644764708380658 0.48745725844372 no 1726 0.474295420835871 2574 21791103
SGTC_751 0833-0568 350 µM -0.0644908033680673 0.487450791072648 no 1727 0.474289714859132 2574 6954252
SGTC_1984 st072354 53.1 µM -0.0646278146321097 0.487388966656811 no 1728 0.474235169062414 2547 5762938
SGTC_1436 4092-1007 8.32 µM -0.0657527834476275 0.48688135181442 no 1729 0.473787324093292 2536 2881121
SGTC_1255 0566-0045 221 µM -0.0658155323630259 0.486853038509274 no 1730 0.473762345005605 2606 2788469
SGTC_2846 9008642 19.48 µM -0.0663252938237057 0.486623028527355 no 1731 0.473559422999586 2619 2992898
SGTC_1325 1431-0015 227 µM -0.0668635702998118 0.48638015708838 no 1732 0.473345157398966 2526 1103340
SGTC_2085 5307070 144.047 µM -0.0668809350422231 0.486372322164974 no 1733 0.47333824534133 2523 2840351
SGTC_1267 0828-0272 9.49 µM -0.0668897020901267 0.486368366499378 no 1734 0.473334755609895 2560 745334
SGTC_1130 3454-2858 15.9 µM -0.0673455298985602 0.486162700222666 no 1735 0.47315331575948 2622 715628 YIL048W NEO1
SGTC_2682 pyrogallin 40.03 µM -0.0676946185751417 0.486005196371489 no 1736 0.473014366620566 2536 822798 An ATP competetive kinase inhibitor.
SGTC_2318 6029776 164 µM -0.0677807036115899 0.485966356360713 no 1737 0.472980102358978 2575 818325
SGTC_1821 st053465 65.6 µM -0.068048442413911 0.48584555831027 no 1738 0.472873536077137 2575 675086
SGTC_805 3852-0218 479 µM -0.0682661957048838 0.485747313616146 no 1739 0.472786866624823 2548 6615355
SGTC_2515 chrysin 20.77 µM -0.0686826457456355 0.485559424464368 no 1740 0.472621116133933 2594 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2662 daunorubicin 22.37 µM -0.0689069837468727 0.485458211544591 no 1741 0.472531829754519 2493 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_66 0109-0187 42.4 µM -0.069721990792024 0.485090518764981 no 1742 0.472207469126018 2512 759417
SGTC_2636 apigenin dimethyl ether 100 µM -0.0699530447197497 0.484986280411676 no 1743 0.472115516458443 2617 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0701172831059387 0.484912186043092 no 1744 0.472050155314648 2506 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0701522005873367 0.484896433466715 no 1745 0.472036259473058 2529 3256 An antibiotic and ribosome inhibitor.
SGTC_1363 1636-0063 10.4 µM -0.0706474312863044 0.484673019002784 no 1746 0.471839179992476 2538 6072185
SGTC_3188 9110789 49.47 µM -0.0716857585020296 0.48420461197077 no 1747 0.47142599503536 2578 849217
SGTC_1975 st070967 30.8 µM -0.0726054721935351 0.483789731696395 no 1748 0.471060036017691 2544 261391
SGTC_93 0109-0045 59.227 µM -0.0730872816987807 0.483572395752601 no 1749 0.470868331162174 2508 88733
SGTC_254 nsc-64875 3.808 µM -0.0756862669092523 0.482400124230183 no 1750 0.469834351035568 2666 56993
SGTC_996 3970-0799 1.8 µM -0.0758698731416391 0.482317314327743 no 1751 0.469761312752409 2540 6615648 YGL040C HEM2
SGTC_1330 1469-0054 61.8 µM -0.076114984104264 0.482206765811966 no 1752 0.469663809566215 2571 7102664
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0762917315892821 0.482127051041305 no 1753 0.469593501954671 2642 5282362
SGTC_2995 9067767 71.4286 µM -0.077638516794535 0.481519662000495 no 1754 0.469057801431975 2605 11673567
SGTC_411 enrofloxacin 100 µM -0.0783849470730519 0.48118304647471 no 1755 0.468760923591296 2597 71188 A bacterial gyrase inhibitor.
SGTC_1503 4585-0012 61.3 µM -0.0792400272673155 0.480797449909187 no 1756 0.46842085375702 2715 2922052
SGTC_2406 ethylparaben 405.7 µM -0.0804395531706033 0.480256556656776 no 1757 0.467943834964088 2560 8434 A possible steroid mimic.
SGTC_1229 0139-0193 12.2 µM -0.0805655209372504 0.480199757044902 no 1758 0.467893743671574 2564 3090752
SGTC_147 4466-0538 29.23 µM -0.0814854296357456 0.4797849770269 no 1759 0.467527955905061 2720 6742687 YHR072W ERG7
SGTC_3059 1327-0034 3 µM -0.0815469995082276 0.479757216404014 no 1760 0.467503474552988 2571 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_507 nimesulide 162 µM -0.0818641794524251 0.479614207875766 no 1761 0.467377359725515 2674 4495 A COX2 inhibitor.
SGTC_1278 0874-0585 172 µM -0.0825027842895818 0.479326284856874 no 1762 0.467123452170929 2593 766306
SGTC_2769 toremifene 3.73 µM -0.0831228114701856 0.479046748127744 no 1763 0.466876943840463 2650 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2373 9071805 200 µM -0.0833955466627431 0.47892378983262 no 1764 0.466768514713474 2560 10149009
SGTC_590 k048-0076 22.4 µM -0.0851027893968304 0.478154152819518 no 1765 0.466089836368232 2615 6832814
SGTC_2187 6125751 200 µM -0.0852222321176721 0.478100310217908 no 1766 0.466042358101087 2587 874498
SGTC_1165 k072-0275 30.3 µM -0.0852924940019787 0.478068637627701 no 1767 0.46601442935391 2560 6153523 YGL055W OLE1
SGTC_138 0850-0259 40.9225 µM -0.086647560343957 0.477457829351023 no 1768 0.465475830172218 2563 6813004
SGTC_2718 lomofungin 53.02 µM -0.0871096641260321 0.477249543972736 no 1769 0.465292171863438 2627 5351222 A RNA synthesis inhibitor.
SGTC_304 1310-0298 97 µM -0.0871188660827256 0.47724539641102 no 1770 0.465288514717062 2564 1550234
SGTC_1820 st053765 18.6 µM -0.0875090254090052 0.477069543707259 no 1771 0.465133455857715 2628 3690829
SGTC_2337 9009472 200 µM -0.0887658214746383 0.476503110817246 no 1772 0.464634010471472 2588 5742383
SGTC_2692 st077426 47.7 µM -0.0892949683115107 0.476264640619542 no 1773 0.46442374640138 2593 25238571
SGTC_1285 0929-0069 65.5 µM -0.0895032072605955 0.476170796058838 no 1774 0.46434100239505 2596 1206237
SGTC_2270 7924575 90.91 µM -0.0897248170879332 0.476070927255942 no 1775 0.464252947147526 2759 1262135
SGTC_1447 4239-0816 81.9 µM -0.0902070503538578 0.475853613310176 no 1776 0.46406134089969 2574 1341554
SGTC_3036 9090181 49.47 µM -0.090738613516901 0.475614077628421 no 1777 0.463850144011369 2561 25236586
SGTC_2909 7941780 10.49 µM -0.0907510816361025 0.475608459286914 no 1778 0.463845190389125 2568 1243215
SGTC_1074 carmofur 3.8 µM -0.092053960536647 0.475021387367856 no 1779 0.46332758362048 2565 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_873 0591-4978 488 µM -0.0923109092912386 0.474905613668745 no 1780 0.463225510509591 2697 3305145
SGTC_292 k038-0015 474 µM -0.0929123670520828 0.474634622448121 no 1781 0.462986590381497 2660 46368540
SGTC_845 0330-0138 4.51 µM -0.0931365894641268 0.474533600386366 no 1782 0.462897524783169 2553 9039800
SGTC_101 0490-5701 117.494 µM -0.0932633709755898 0.474476480461681 no 1783 0.462847165469998 2575 4661669
SGTC_2322 7413319 38.22 µM -0.0932899460695376 0.474464507430917 no 1784 0.462836609562468 2671 1840400
SGTC_3252 9135871 49.47 µM -0.0937371310970175 0.474263038042168 no 1785 0.462658986885458 2690 17682838
SGTC_1365 1672-3266 55.4 µM -0.0938828780553074 0.474197376372071 no 1786 0.462601097545111 2583 6415873
SGTC_1696 st025591 34.7925 µM -0.0958210995208893 0.473324239490225 no 1787 0.461831329735793 2595 2787147
SGTC_663 1486-0733 13.9 µM -0.0959743940152374 0.473255188256019 no 1788 0.461770454640431 2605 722445 YPR165W RHO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0961885050605143 0.473158743659452 no 1789 0.461685430057466 2735 165506
SGTC_1374 2889-5571 141 µM -0.0966313098218517 0.472959290817839 no 1790 0.461509595598714 2630 2853281
SGTC_3058 9093861 49.47 µM -0.0967676701843523 0.472897871292536 no 1791 0.461455449432259 2667 17217477
SGTC_2926 9010726 65.15 µM -0.0968131698996553 0.472877377423766 no 1792 0.461437382499594 2660 2994293
SGTC_2423 st077119 87.2 µM -0.0969517247094173 0.472814970352873 no 1793 0.46138236593318 2528 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_779 1360-0071 233 µM -0.098974073146998 0.471904152388951 no 1794 0.460579427820207 2759 7566
SGTC_2544 sphondin 68.51 µM -0.0991206635278345 0.471838137197546 no 1795 0.460521232877983 2782 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_664 1222-0054 14.9 µM -0.0991577012728295 0.471821457822859 no 1796 0.460506529390555 2609 6813991
SGTC_1913 st060213 96.1 µM -0.0996246035420372 0.471611199866904 no 1797 0.460321180096785 2645 688959
SGTC_3208 9114115 49.47 µM -0.100820990141697 0.471072472830466 no 1798 0.459846282008806 2658 650895
SGTC_3341 9147222 25.867 µM -0.100857667060215 0.471055958224576 no 1799 0.459831724239622 2689 1939759
SGTC_2902 5787006 60.46 µM -0.10131258201586 0.470851126700091 no 1800 0.459651164291017 2602 591003
SGTC_1484 3473-2379 286 µM -0.101555252271043 0.470741864332484 no 1801 0.459554849626005 2573 671917
SGTC_1759 st043059 70 µM -0.101907773340206 0.470583145523228 no 1802 0.459414939927691 2606 669426
SGTC_3305 9127027 53.8275 µM -0.102235323813499 0.470435673643131 no 1803 0.459284945144287 2636 41905295
SGTC_556 4058-0063 51.5 µM -0.103158736443229 0.470019950764947 no 1804 0.458918494340782 2600 6615692
SGTC_1613 st002381 52.1 µM -0.103730756336789 0.469762442213936 no 1805 0.458691509141205 2603 551167
SGTC_1321 1326-2144 215 µM -0.104629690569849 0.469357790882081 no 1806 0.458334827169159 2701 3513030
SGTC_1794 st048918 76.9 µM -0.106105152791539 0.468693686780394 no 1807 0.457749461445444 2565 672303
SGTC_269 exalamide 29 µM -0.106662739283196 0.468442740224077 no 1808 0.457528271831504 2630 3316 A derivative of salicylamide.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.106794128873729 0.46838360903988 no 1809 0.457476152659282 2788 641818
SGTC_2312 7706453 155.7 µM -0.107059204504747 0.468264315290853 no 1810 0.457371005593865 2625 976098
SGTC_3312 9133330 71.43 µM -0.107304496835752 0.468153927290211 no 1811 0.457273708591865 2742 17617324
SGTC_2871 9038510 12.99 µM -0.107714162981355 0.467969572213487 no 1812 0.457111217223786 2591 4945164
SGTC_854 0422-0053 192 µM -0.108084950088096 0.467802719129503 no 1813 0.456964153150338 2605 3596728
SGTC_1679 SEC14.276 6.7 µM -0.108313259068325 0.467699983586239 no 1814 0.456873602639166 2747 1005053 YMR079W SEC14
SGTC_293 4049-0273 38.5 µM -0.108468247476572 0.467630242402593 no 1815 0.456812133360462 2610 1380311
SGTC_3334 9142812 21.919 µM -0.108521513836694 0.467606274007114 no 1816 0.456791007859506 2705 45283678
SGTC_3209 9113616 49.47 µM -0.108963880993602 0.467407225511998 no 1817 0.456615569249598 2639 16649353
SGTC_2844 9010103 25.97 µM -0.109874696994951 0.466997418467865 no 1818 0.456254374948137 2764 2480525
SGTC_108 0509-0257 621.132 µM -0.109980453358188 0.466949837347695 no 1819 0.45621243841251 2683 536624
SGTC_1244 0416-0015 52.5 µM -0.111042716336553 0.466471938161044 no 1820 0.455791236714385 2638 96201
SGTC_3203 9113543 49.47 µM -0.111636117545378 0.466204995177033 no 1821 0.455555966673541 2762 17018012
SGTC_2882 9058044 58.44 µM -0.112424019158817 0.465850579225066 no 1822 0.455243605758209 2686 18076804
SGTC_3278 9139605 49.47 µM -0.112492104447065 0.465819954190962 no 1823 0.455216614873193 2818 7958859
SGTC_3338 9144300 39.5675 µM -0.113067009095364 0.465561367876334 no 1824 0.454988715078135 2660 4901274
SGTC_1621 st003705 32.4 µM -0.113112996263751 0.465540683938264 no 1825 0.454970485796144 2706 24207032
SGTC_2400 5203494 178.7 µM -0.113999567992135 0.46514194325715 no 1826 0.45461906795222 2590 6777674
SGTC_1323 1348-1351 11.2 µM -0.116535438465996 0.464001615658723 no 1827 0.453614100792525 2616 6989654
SGTC_2649 anisomycin 9.56 µM -0.116602987153694 0.463971244436249 no 1828 0.453587335234492 2664 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1856 st057054 55.7 µM -0.117267501183801 0.463672477039524 no 1829 0.453324038802658 2818 1266018
SGTC_2817 7995342 71.43 µM -0.118094161632155 0.463300836765413 no 1830 0.452996524712352 2618 18879975
SGTC_1955 wogonin 32.4 µM -0.118839429392009 0.462965815500305 no 1831 0.452701284939313 2875 5281703 A flavanone.
SGTC_1699 st031318 29.054 µM -0.119209989290329 0.462799246949673 no 1832 0.452554496388561 2717 5340658
SGTC_3257 9139206 32.98 µM -0.120168623298832 0.462368366443568 no 1833 0.452174786303538 2714 4910041
SGTC_2118 5526350 200 µM -0.120411182117033 0.462259349681928 no 1834 0.452078716901873 2755 743594
SGTC_2814 7977482 42.97 µM -0.121379736218341 0.461824066572137 no 1835 0.451695133177116 2738 6456762
SGTC_2968 9090663 33.37 µM -0.122512701622402 0.461314952554216 no 1836 0.451246493663756 2724 25236811
SGTC_1868 st057644 42.7 µM -0.122825735211125 0.461174297628375 no 1837 0.451122547402934 2607 688665
SGTC_538 2922-0838 53.3 µM -0.123976898638518 0.460657088949232 no 1838 0.450666783072879 2615 777039
SGTC_3103 9120822 49.47 µM -0.124251914759694 0.460533536183751 no 1839 0.45055790931906 2815 17141819
SGTC_1134 3477-0009 42.5 µM -0.124545669841897 0.460401569027931 no 1840 0.450441621269389 2852 3973534
SGTC_1030 k029-0042 36.7 µM -0.125006982770484 0.460194336638293 no 1841 0.450259011127377 2675 6080581
SGTC_79 0052-0007 94.094 µM -0.12593329375377 0.459778249124731 no 1842 0.449892363931279 2723 2801472
SGTC_491 tetrandrine 80.3 µM -0.127753109842361 0.458960938787489 no 1843 0.449172179411357 2722 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_228 caffeine 993.056 µM -0.129925585821918 0.457985470293452 no 1844 0.44831265065175 2762 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.130398413360313 0.457773198222813 no 1845 0.448125610914246 2743 23847180
SGTC_1147 3809-1045 12.3 µM -0.130517074876373 0.457719927990334 no 1846 0.448078672946632 2659 325925
SGTC_1870 st057514 26.5 µM -0.130842339198599 0.457573912296383 no 1847 0.447950014522128 2621 5393161
SGTC_2954 9074818 52.69 µM -0.131299672584747 0.45736861864695 no 1848 0.447769125394499 2740 16648742
SGTC_3137 9097352 49.47 µM -0.132593332237604 0.456787965961923 no 1849 0.447257502980885 2901 44120435
SGTC_3067 9117431 49.47 µM -0.132888528177332 0.456655481618443 no 1850 0.447140769811784 2689 17150885
SGTC_1574 spiramycin 23.7 µM -0.134195057370918 0.456069167572374 no 1851 0.446624167104453 2619 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2481 5478948 45.16 µM -0.134908824074141 0.455748900126809 no 1852 0.44634198136735 2766 77792
SGTC_2453 5731132 22.18 µM -0.135182190251949 0.455626248201353 no 1853 0.44623391397602 2749 1362040
SGTC_286 k060-0067 22.9 µM -0.135194027829329 0.455620937099671 no 1854 0.44622923442322 2665 5985051
SGTC_3089 9117425 49.47 µM -0.135823490994458 0.455338530720214 no 1855 0.445980410010994 2712 9401657
SGTC_391 gliotoxin 8.33 µM -0.136336445274162 0.45510841231362 no 1856 0.445777656847665 2769 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2761 levamisole 97.89 µM -0.13646275634433 0.455051749723342 no 1857 0.445727732604693 2717 26879 An alkaline phosphatase inhibitor.
SGTC_772 k072-0172 35.3 µM -0.136615632490546 0.454983171380131 no 1858 0.445667309710156 2675 5861980
SGTC_679 0422-0091 41.4 µM -0.136788530742483 0.45490561298538 no 1859 0.445598974782729 2629 627384 YHR062C RPP1
SGTC_641 4092-0595 30 µM -0.138916642537796 0.453951130019944 no 1860 0.444758009819441 2699 786260
SGTC_2243 6634756 200 µM -0.139927792090204 0.453497710493229 no 1861 0.444358521198722 2938 885676
SGTC_1967 st070177 51.4 µM -0.140295119375225 0.453333008626399 no 1862 0.444213410181321 2791 5729214
SGTC_2841 9004761 38.96 µM -0.140595174848786 0.45319847598704 no 1863 0.444094880143416 2674 2991039
SGTC_1177 0983-0204 23.6 µM -0.142351618900477 0.452411066339099 no 1864 0.443401137820554 2761 766818
SGTC_2271 7849410 118.62 µM -0.142683178609306 0.452262449820352 no 1865 0.443270201150924 2633 972430
SGTC_2135 5326629 150.42 µM -0.142848438537344 0.452188377106312 no 1866 0.443204940453141 2706 5020077
SGTC_359 0081-0058 15.9 µM -0.143360168172289 0.451959020497067 no 1867 0.443002869585838 3006 3494159
SGTC_2160 5660466 132.927 µM -0.144271217275667 0.45155072910914 no 1868 0.442643152894716 2621 2859134
SGTC_691 1548-0686 185 µM -0.144678779462262 0.451368094562502 no 1869 0.442482247195598 2678 46495133
SGTC_2639 lactacystin 53 µM -0.144889088626978 0.451273855989248 no 1870 0.442399220770465 2759 3870 A proteasome inhibitor.
SGTC_1298 1079-1278 263 µM -0.145508106489595 0.450996492877667 no 1871 0.442154857907403 2686 2840950
SGTC_1718 roemerine 11.9335 µM -0.145562737039628 0.450972015733678 no 1872 0.442133293062503 2733 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.14797566366008 0.449891094521216 no 1873 0.44118098718278 2700 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2387 9077560 195.08 µM -0.148001878233672 0.449879353178178 no 1874 0.44117064297603 2653 5303272
SGTC_1356 1502-0781 85.8 µM -0.148079509866737 0.449844582714194 no 1875 0.441140009958555 2666 567702
SGTC_1226 3909-7979 35.4 µM -0.148709395718101 0.449562477141507 no 1876 0.440891473485287 2799 6615510
SGTC_1830 st055982 50.3 µM -0.148838618325963 0.449504605646518 no 1877 0.440840488500521 2650 455313 An antimicrobial agent.
SGTC_59 0330-0160 1.33 µM -0.150659704601653 0.448689158920845 no 1878 0.440122080694457 2684 4293482
SGTC_2099 5377090 177.372 µM -0.151100208768568 0.448491942213364 no 1879 0.439948333909041 2752 2243829
SGTC_943 3253-1379 105 µM -0.151224434216375 0.448436327935389 no 1880 0.439899338113716 2797 668464
SGTC_2802 7925815 54.55 µM -0.151846615828235 0.448157799784169 no 1881 0.439653957145787 2688 1262923
SGTC_1518 st038567 90.8 µM -0.151919336797727 0.448125246907928 no 1882 0.43962527837862 2650 77966
SGTC_2791 5663188 71.43 µM -0.151968817953317 0.44810309732132 no 1883 0.439605764813571 2809 54690634
SGTC_708 3448-5400 146 µM -0.152256178134687 0.447974467527067 no 1884 0.439492443329214 2678 3462195
SGTC_1645 Cervolide 78 µM -0.152767880963723 0.447745429756426 no 1885 0.439290663824366 2748 23173 A fragrance.
SGTC_97 0535-0701 19.132 µM -0.152769660312337 0.447744633351783 no 1886 0.439289962202261 2702 2832013 YGL099W LSG1
SGTC_261 5-fluorouridine 15.376 µM -0.152970869799853 0.447654576940247 no 1887 0.439210623711067 2860 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3309 9129340 25.759 µM -0.154093281884614 0.447152262568674 no 1888 0.438768092647557 2730 17158987
SGTC_1506 4226-2149 212 µM -0.154207725333872 0.447101050308552 no 1889 0.438722975558685 2775 991114
SGTC_1712 st032288 53.4 µM -0.154375225728701 0.44702609720437 no 1890 0.43865694324362 2724 2883011
SGTC_1288 0973-0013 65.5 µM -0.154414739164925 0.447008416001163 no 1891 0.438641366432634 2765 4315430
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.155490370717106 0.446527140299317 no 1892 0.438217372336442 2733 4330530
SGTC_488 nitrendipine 139 µM -0.157560197843301 0.445601248422947 no 1893 0.437401684621687 2674 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1511 0906-3109 28.5 µM -0.159421199992114 0.444769022908322 no 1894 0.436668518662915 2670 2882180
SGTC_141 0443-0274 32.331 µM -0.159692886852064 0.444647546956375 no 1895 0.436561502231033 2781 1627241
SGTC_631 k072-0230 41.5 µM -0.160037219568799 0.444493597240886 no 1896 0.436425877541639 2802 5773147
SGTC_2163 5671233 125 µM -0.160222665850314 0.44441068845281 no 1897 0.436352837637875 2777 701023
SGTC_2357 9067248 200 µM -0.161997226759024 0.443617446400724 no 1898 0.435654018875357 2778 9150235
SGTC_3056 9094900 49.47 µM -0.162638887095266 0.443330674846209 no 1899 0.435401383570328 2744 25236784
SGTC_630 4356-0227 183 µM -0.162679239233073 0.443312641614008 no 1900 0.435385496956512 2700 779312
SGTC_444 curcumin 90.4 µM -0.162819628969142 0.443249902836756 no 1901 0.435330226409613 2810 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2899 9053889 58.44 µM -0.16305582166985 0.443144353878097 no 1902 0.435237241695652 2707 6470052
SGTC_2823 7987624 58.44 µM -0.163231304602552 0.443065937297524 no 1903 0.435168159617018 2851 2239440
SGTC_259 usnic acid 108.925 µM -0.164728276277462 0.442397089126782 no 1904 0.434578929880219 2871 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2321 7390090 138.78 µM -0.166465114214739 0.44162127435419 no 1905 0.433895467459945 2796 649046
SGTC_1597 7-benzyloxygramine 47.5 µM -0.168676059144361 0.440634008692767 no 1906 0.433025725481492 2684 260807
SGTC_1003 4049-0218 100 µM -0.169500902243054 0.440265781025703 no 1907 0.432701331371014 2867 295161
SGTC_1469 k284-2957 126 µM -0.169576436342241 0.440232063559217 no 1908 0.432671627600665 2733 23884841
SGTC_3217 9129673 49.47 µM -0.173371092163409 0.438538740090599 no 1909 0.431179873058052 2874 17248312
SGTC_186 3455-3465 67.277 µM -0.173550101720025 0.438458886574626 no 1910 0.431109524916257 2709 755278
SGTC_63 0099-0242 26.702 µM -0.174188731045199 0.43817402391136 no 1911 0.430858570738532 2812 3898502 YLR359W ADE13
SGTC_3306 9127676 59.7925 µM -0.174199773848166 0.438169098514908 no 1912 0.43085423163161 2778 41905287
SGTC_1259 0671-0132 43 µM -0.174633076007671 0.437975841300804 no 1913 0.430683978519049 2744 X1259
SGTC_1728 st035614 33.7865 µM -0.174806233334872 0.437898615488408 no 1914 0.430615945131793 2836 15945546
SGTC_583 1488-1091 88.9 µM -0.175354374418315 0.437654167629604 no 1915 0.430400594487442 2743 4303273
SGTC_180 1486-1293 102.781 µM -0.175400264431322 0.437633703692804 no 1916 0.430382566410432 2759 4140536
SGTC_1078 idebenone 36.1 µM -0.176017992756316 0.437358253622214 no 1917 0.430139903480765 2791 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1482 3346-2049 8.48 µM -0.176510701576681 0.437138572520287 no 1918 0.429946371017262 2813 3826804
SGTC_2418 pentamidine 31.67 µM -0.177604113952092 0.436651128679424 no 1919 0.429516946723288 2688 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1369 1866-0067 208 µM -0.179185596658583 0.435946273150119 no 1920 0.428895986447652 2781 3531355
SGTC_2218 6965428 192.983 µM -0.179926004403654 0.435616348480849 no 1921 0.428605329893684 2716 675684
SGTC_1283 0922-0125 16.4 µM -0.180020540450615 0.4355742265697 no 1922 0.428568221340461 2842 3360884
SGTC_2974 9094440 9.66 µM -0.18036859977372 0.435419149977287 no 1923 0.428431601886257 2934 25236134
SGTC_369 0957-0393 4.5 µM -0.181124202305246 0.435082528172141 no 1924 0.428135044039224 2784 6997992
SGTC_220 paclitaxel 373.376 µM -0.182787974317304 0.434341481982396 no 1925 0.427482192372892 2841 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1119 parthenolide 318.541 nM -0.182941611735278 0.434273063272638 no 1926 0.42742191618708 2926 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1853 st056710 91.2 µM -0.183530094010092 0.434011015148809 no 1927 0.427191054085146 2903 269167
SGTC_513 4245-1575 41.7 µM -0.18371141771759 0.433930278474987 no 1928 0.427119925660028 2847 719745
SGTC_800 3448-7362 155 µM -0.183897848611909 0.433847270635481 no 1929 0.427046796292958 2797 15991913
SGTC_2568 diosmetin 100 µM -0.184079023439689 0.433766605840108 no 1930 0.426975731072201 2771 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1831 st055328 12 µM -0.185454235314426 0.433154407946282 no 1931 0.426436386241767 2874 1103068
SGTC_704 1310-0270 142 µM -0.185962692312137 0.432928100590096 no 1932 0.4262370090863 2815 5718033
SGTC_1591 genipin 88.4 µM -0.187132672343991 0.432407441904891 no 1933 0.425778305897358 2890 442424 A DNA cross-linking agent.
SGTC_612 0302-0167 22.4 µM -0.187216621298161 0.432370087861052 no 1934 0.425745396665633 2815 235821
SGTC_1463 k081-0032 34.1 µM -0.187843443652821 0.432091195240633 no 1935 0.42549968939538 2808 977755
SGTC_971 1315-0384 26.7 µM -0.188483715371526 0.431806353517908 no 1936 0.42524873999399 2774 6769120
SGTC_3161 9100388 49.47 µM -0.18950826894665 0.4313506277092 no 1937 0.424847237420792 2761 25236368
SGTC_382 3229-0966 23.2 µM -0.190716511044345 0.43081331391353 no 1938 0.424373851091872 2911 5722370
SGTC_2379 9035213 200 µM -0.191614500002362 0.430414054770862 no 1939 0.424022091810752 2860 646551
SGTC_2131 toluylene red 5.2905 µM -0.191761504275208 0.430348701266006 no 1940 0.423964513210563 2784 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2646 retinol 96.75 µM -0.192636032652862 0.429959952778857 no 1941 0.423622011724389 2819 445354 A vitamin A analog and teratogen.
SGTC_1908 st060353 56.5 µM -0.194389412183085 0.429180739108455 no 1942 0.422935489827319 2932 4227716
SGTC_651 3253-0966 34.4 µM -0.194588153296746 0.429092434570671 no 1943 0.422857689039036 2778 781462
SGTC_809 3998-0021 90 µM -0.194635292244157 0.429071490341061 no 1944 0.422839236090433 2868 715485
SGTC_2217 6934799 96.0675 µM -0.19579550083296 0.428556063022647 no 1945 0.422385115866599 2815 675606
SGTC_2564 betulinic acid 100 µM -0.197750010878829 0.427688040034599 no 1946 0.421620329618793 3019 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_923 1900-2434 73.3 µM -0.198194517173997 0.427490677769313 no 1947 0.421446438531622 2737 5910570
SGTC_2730 imipramine 71.33 µM -0.198261764367492 0.427460821371861 no 1948 0.421420132728815 2761 3696 A tricyclic antidepressant.
SGTC_2291 7917025 104.35 µM -0.19871360706092 0.427260223111721 no 1949 0.421243389698102 2758 2964612
SGTC_1791 st048313 56.1 µM -0.199829572480211 0.426764864291638 no 1950 0.420806936132858 2902 1204976
SGTC_190 3970-0790 3.722 µM -0.200461697411807 0.426484325542837 no 1951 0.420559755502982 2746 2832352
SGTC_1889 st059080 5.18 µM -0.20065955557923 0.426396523190333 no 1952 0.420482393199206 2768 176925 Isolated from Daphnopsis sellowiana.
SGTC_2091 4-phenylthiadiazole 200 µM -0.201391337947817 0.426071816171267 no 1953 0.42019629388891 2785 270010
SGTC_2893 9048488 25.97 µM -0.201970660456136 0.425814794285071 no 1954 0.419969830527434 2775 6467338
SGTC_3224 9130643 49.47 µM -0.20210992345203 0.425753013639909 no 1955 0.419915395081112 2961 17644395
SGTC_2561 acetosyringone 100 µM -0.20227031759109 0.425681860934898 no 1956 0.419852701742574 2750 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_795 0685-0265 78 µM -0.202578422161592 0.425545188955939 no 1957 0.4197322784601 2759 302754
SGTC_1952 st077036 64.1 µM -0.202624636462663 0.425524689544371 no 1958 0.419714216156832 2731 2937007
SGTC_3189 9110682 49.47 µM -0.202645430218828 0.425515466063303 no 1959 0.41970608922271 2866 17122418
SGTC_1555 citronellol 128 µM -0.202757910806855 0.425465573784546 no 1960 0.419662128431026 2816 8842 A terpine precursor.
SGTC_275 trichlorophene 5.69 µM -0.204163553593439 0.424842182908221 no 1961 0.419112845739609 2855 62616
SGTC_1301 naphtanilide LB 4.81 µM -0.204205717247804 0.424823486573581 no 1962 0.419096371888162 2896 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_922 1866-0035 480 µM -0.204768887129968 0.424573780318299 no 1963 0.418876348191446 2781 3156169
SGTC_2851 9015922 71.43 µM -0.204847808810379 0.424538789319312 no 1964 0.41884551646589 2954 2996893
SGTC_1789 tunicamycin 25 nM -0.204997584774896 0.42447238574648 no 1965 0.418787006013139 2877 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1015 4130-4525 82 µM -0.20518652250219 0.42438862275969 no 1966 0.418713199456892 2784 1363237
SGTC_1350 1495-0454 146 µM -0.206140168308346 0.423965888978913 no 1967 0.418340711370369 2935 1069057
SGTC_2276 7947513 42.08 µM -0.206692895033822 0.423720915320519 no 1968 0.418124853264531 2847 2105100
SGTC_355 1311-2252 105 µM -0.207101584049121 0.423539799473815 no 1969 0.417965262512399 2796 5338538
SGTC_2659 sanguinarine 24.21 µM -0.207329010543189 0.423439019461301 no 1970 0.417876459598983 2770 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.207531321475653 0.42334937317309 no 1971 0.417797467043641 2934 688751
SGTC_2195 6536160 144.242 µM -0.207641726533704 0.423300453102266 no 1972 0.41775436064992 2765 3834386
SGTC_3104 9120930 49.47 µM -0.207986962970274 0.423147487753423 no 1973 0.417619573405667 2852 17014836
SGTC_166 k072-0058 166.424 µM -0.208045463997083 0.423121568606489 no 1974 0.417596734387407 2802 5846229
SGTC_2188 6126565 140.678 µM -0.208625598434961 0.422864555424038 no 1975 0.417370262805078 2875 874518
SGTC_2514 salinomycin 42.74 µM -0.210646396337735 0.421969551511239 no 1976 0.416581602734533 2936 23682228 A polyether potassium ionophore.
SGTC_724 3910-0327 137 µM -0.211983640542863 0.421377512201683 no 1977 0.416059898624015 2837 2885483
SGTC_2585 alliin 100 µM -0.213635367877028 0.420646486935999 no 1978 0.415415708243569 2988 87310 A garlic compound which reacts with lipids.
SGTC_1650 st011916 45.8 µM -0.214980534363245 0.420051342071514 no 1979 0.414891247535528 2867 242528
SGTC_3026 9090633 49.47 µM -0.215120120891343 0.419989594951286 no 1980 0.414836833461923 2774 25236842
SGTC_680 0417-1641 114 µM -0.215812643549214 0.419683281647571 no 1981 0.414566896212273 2776 2835990
SGTC_802 4112-3352 742 µM -0.216525813153309 0.419367886741041 no 1982 0.414288953187735 2943 704594
SGTC_1810 st050138 53 µM -0.217052031572968 0.419135203054088 no 1983 0.414083898008398 2836 3444541
SGTC_742 0kpi-0133 140 µM -0.217309680710238 0.419021285857917 no 1984 0.413983506620232 2957 2728852
SGTC_648 0375-0473 33.3 µM -0.217561099688095 0.418910129813873 no 1985 0.413885548193483 2807 1713139
SGTC_252 miconazole 1.30953 nM -0.217974852588247 0.418727217640351 no 1986 0.41372435252643 2879 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_221 trifluoperazine 10.304 µM -0.218028647035051 0.418703437443214 no 1987 0.413703395597509 2803 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_75 0159-0059 199.013 µM -0.220154621931462 0.417763874666464 no 1988 0.412875368014787 3108 5377270
SGTC_3145 9085516 49.47 µM -0.220878530799428 0.417444053990281 no 1989 0.412593507258409 2875 25236195
SGTC_1395 3486-0190 4.35 µM -0.220976940885478 0.417400580933337 no 1990 0.412555193838139 2925 6748079
SGTC_586 0957-0265 8.15 µM -0.221942732675451 0.416973992126671 no 1991 0.412179232064325 2840 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3080 9117754 49.47 µM -0.22233148322113 0.416802309144066 no 1992 0.412027922644121 3010 9550191
SGTC_3293 9120939 62.045 µM -0.223060176685863 0.416480540744092 no 1993 0.411744335947197 2954 934087
SGTC_1715 st032160 10.2275 µM -0.223460269925955 0.41630389577911 no 1994 0.411588650669783 2915 5289825
SGTC_3165 9101544 49.47 µM -0.223520614696264 0.416277254456101 no 1995 0.411565170369929 2903 5002184
SGTC_1055 3448-0672 86 µM -0.223797022259053 0.416155229525686 no 1996 0.411457623550373 2951 748378
SGTC_1038 k292-0204 154 µM -0.224696693895625 0.415758109840253 no 1997 0.411107618369599 2772 4454212
SGTC_117 lucigenin 22.078 µM -0.224755819602627 0.415732014456961 no 1998 0.411084618781066 2860 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2003 4023581 200 µM -0.225234593603093 0.415520719204164 no 1999 0.410898389481653 2939 16641307
SGTC_1826 st055655 41.6 µM -0.227135053415631 0.414682238995603 no 2000 0.410159363794794 2874 676168
SGTC_2471 5466956 24.79 µM -0.227418782849539 0.414557091210748 no 2001 0.410049058144516 2826 724419
SGTC_1232 0279-0259 161 µM -0.22794115263403 0.414326706289269 no 2002 0.409845994772315 2827 1560000
SGTC_1732 st034308 51.822 µM -0.229168806221703 0.413785380578514 no 2003 0.409368858234776 2747 830119
SGTC_122 0236-0016 402.397 µM -0.229302807826281 0.41372630335589 no 2004 0.409316785644456 2847 6808838
SGTC_2082 5219693 150 µM -0.229893432081577 0.413465938413932 no 2005 0.409087290047932 2802 2834649
SGTC_759 3486-0358 89.3 µM -0.2311912705672 0.412893945968048 no 2006 0.408583105701098 2975 875103
SGTC_1118 chelidonine 707.474 nM -0.232165962760956 0.412464494309618 no 2007 0.408204556648789 2929 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_930 2810-3379 265 µM -0.232407132594371 0.412358250467247 no 2008 0.408110904784783 3020 1015764
SGTC_3045 9092950 49.47 µM -0.233749976491 0.411766797868718 no 2009 0.407589543344594 2901 44120432
SGTC_1860 st056228 74.6 µM -0.234440155145586 0.411462888105769 no 2010 0.407321643905755 2929 688679
SGTC_2303 7774051 200 µM -0.234557748171082 0.411411113081085 no 2011 0.407276003367711 3002 2953184
SGTC_1411 3909-8223 150 µM -0.234712348909372 0.411343046280758 no 2012 0.407216001206937 2935 X1411
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.236131372852179 0.410718410786308 no 2013 0.406665365076163 2869 676296 Flavone; oxidizing agent.
SGTC_856 0433-0016 11.3 µM -0.238028815526712 0.40988353566646 no 2014 0.405929372422349 2891 3911780
SGTC_2765 myclobutanil 7.74 µM -0.24198685065688 0.408143318078512 no 2015 0.404395176070661 2942 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2532 xanthone 78.9 µM -0.242470288843549 0.407930889613607 no 2016 0.404207888063221 2949 7020 An insecticide.
SGTC_169 k015-0017 16.025 µM -0.244027364832937 0.40724687622989 no 2017 0.403604813193234 3033 1840002
SGTC_3002 9075603 71.4286 µM -0.244032959088438 0.407244419218262 no 2018 0.403602646880818 2837 20105405
SGTC_1179 1021-1431 9.29 µM -0.244096739694207 0.407216406867645 no 2019 0.403577948768889 2905 2840958
SGTC_114 0364-0001 490.298 µM -0.245876956173797 0.406434730312298 no 2020 0.402888741315959 2902 4003655
SGTC_3102 9121669 49.47 µM -0.246218481102385 0.406284812397524 no 2021 0.402756555002106 2857 41905072
SGTC_2869 9037858 32.47 µM -0.248392461780058 0.405330831204916 no 2022 0.401915382744669 2801 27187042
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.248617890938044 0.405231940973398 no 2023 0.401828183993637 2937 140250 A respiratory chain inhibitor.
SGTC_2756 carbadox 75.1 µM -0.248913109159284 0.405102445145362 no 2024 0.401713997371949 2884 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_229 benomyl 22.8748 µM -0.24911983202395 0.405011773496373 no 2025 0.401634044613407 2920 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2180 6301957 200 µM -0.25005158916002 0.404603154645668 no 2026 0.401273726562369 2954 845462
SGTC_3239 9133757 49.47 µM -0.251807065670989 0.403833579468108 no 2027 0.400595097825958 2830 17036923
SGTC_1455 4262-0120 131 µM -0.252399933669466 0.403573758732802 no 2028 0.400365975705049 3050 1529587
SGTC_1989 st071868 50.2 µM -0.252877220566328 0.403364621610442 no 2029 0.400181546421391 2988 16414057
SGTC_1550 gossypolone 36.6 µM -0.254821201955167 0.402513095767451 no 2030 0.399430599464135 2850 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1141 3253-0389 52.6 µM -0.256279972399864 0.401874411188465 no 2031 0.398867330340334 2946 5402031
SGTC_2997 9067075 71.4286 µM -0.258635215975396 0.400843782825225 no 2032 0.397958354537041 2966 27209819
SGTC_2281 7943571 200 µM -0.259682460119577 0.400385741555342 no 2033 0.397554361702833 3054 1244024
SGTC_927 2425-1185 123 µM -0.260838257649973 0.399880380468268 no 2034 0.397108620030197 2840 730375
SGTC_1353 1498-1206 8.11 µM -0.260949019998214 0.399831959511778 no 2035 0.397065910776107 2877 6756808
SGTC_2181 6316240 54.2555 µM -0.26139374756588 0.399637557568451 no 2036 0.396894439099761 2955 12779990
SGTC_2795 7780010 54.55 µM -0.262815742713174 0.399016133808978 no 2037 0.396346300520204 3015 953673
SGTC_1883 5-benzylidenerhodanine 20 µM -0.263943099332033 0.39852365129019 no 2038 0.395911882194581 2986 1273210
SGTC_960 1222-0186 7.7 µM -0.264174479998646 0.398422593263556 no 2039 0.395822737377626 2985 3126296
SGTC_2842 9000675 19.48 µM -0.264538209609433 0.398263744166773 no 2040 0.395682613049404 2936 2989072
SGTC_1921 5740136 50 µM -0.264795964459492 0.398151186892868 no 2041 0.39558332292933 3080 1774243
SGTC_2952 9073731 13.78 µM -0.265233530498317 0.397960128460431 no 2042 0.395414782999925 2904 16457353
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.26612427602731 0.39757126979675 no 2043 0.395071749681282 2969 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1414 3917-0015 5.4 µM -0.268996002998402 0.396318300169613 no 2044 0.393966379245779 2963 6618702
SGTC_313 3474-0040 5.03 µM -0.269779178634159 0.395976776229682 no 2045 0.393665071067765 2871 1043375 YIL048W NEO1
SGTC_305 1682-2595 20.8 µM -0.269806068596052 0.395965051584215 no 2046 0.393654726924514 2943 226033
SGTC_2149 5554786 194.827 µM -0.270045056582189 0.395860851430111 no 2047 0.393562795322574 2880 745063 YPR165W RHO1
SGTC_3268 9137683 49.47 µM -0.271746815035721 0.395119090404328 no 2048 0.392908351053832 2859 1953228
SGTC_2355 9061122 103.12 µM -0.2720713320817 0.394977683239863 no 2049 0.392783586017968 3017 5302957
SGTC_2627 acetyl isogambogic acid 100 µM -0.27418685688379 0.394056190519438 no 2050 0.391970513960511 2976 6857789 A caspase activator and apoptosis inducer.
SGTC_2431 5490079 200 µM -0.275178082323769 0.393624630341739 no 2051 0.39158971247832 2954 5722345
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.275290083428695 0.393575875454827 no 2052 0.391546691266045 2952 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2349 9023730 187.07 µM -0.275858426031722 0.393328497560347 no 2053 0.391328403268484 3043 4126287
SGTC_2661 dactinomycin 12.96 µM -0.276191016615538 0.393183753508549 no 2054 0.391200678347743 2918 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1838 st055369 84.5 µM -0.27705283865136 0.392808755670804 no 2055 0.390869767039952 2874 676036
SGTC_1409 3909-8004 61.9 µM -0.277457266151821 0.392632814586562 no 2056 0.390714507407073 2930 2119279
SGTC_3063 1327-0034 4 µM -0.277679446219076 0.392536167284404 no 2057 0.390629219938336 2982 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3087 9117406 49.47 µM -0.278472727073051 0.392191147888677 no 2058 0.390324749008834 3020 42546093
SGTC_1293 1000-1278 195 µM -0.278957113083219 0.39198051690297 no 2059 0.39013886877077 3031 678847
SGTC_1754 st042065 16.137 µM -0.2807368975887 0.391206865557285 no 2060 0.389456103078798 2945 1126236 YIL048W NEO1
SGTC_3120 9124077 49.47 µM -0.283061823864123 0.390196896011495 no 2061 0.388564722705254 2916 18774327 YGL155W CDC43
SGTC_2698 st077697 67.5 µM -0.283707544906307 0.389916519930794 no 2062 0.388317256111437 2944 3154499
SGTC_2478 5763493 32.33 µM -0.284503042543004 0.389571188668381 no 2063 0.388012451360569 2896 1365576 YLR208W SEC13
SGTC_211 3455-0679 143.504 µM -0.285536844027053 0.389122538275599 no 2064 0.387616440637187 2991 748649
SGTC_3353 9151644 39.2805 µM -0.285946729472112 0.388944696585732 no 2065 0.387459461173166 3034 4909158
SGTC_1781 st038725 66.3 µM -0.286460321779843 0.38872189125811 no 2066 0.387262789638046 2920 4270275 YIL048W NEO1
SGTC_2569 tetrandrine 100 µM -0.286898020455105 0.388532038799473 no 2067 0.387095203126715 2957 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2676 harmalol 100 µM -0.288282378079013 0.387931747073412 no 2068 0.386565297549876 3023 5459187 A monoamine oxidase inhibitor
SGTC_2722 naftopidil 47.16 µM -0.288436422239079 0.387864966239349 no 2069 0.386506345452276 3001 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_124 0136-0217 7.121 µM -0.289314857337518 0.387484212714799 no 2070 0.386170221869947 3066 3976905
SGTC_3267 9137951 49.47 µM -0.289332312751075 0.387476647843775 no 2071 0.386163543611571 2864 16643986
SGTC_625 k213-0058 121 µM -0.289905469626415 0.387228275424233 no 2072 0.385944278541971 2977 3655420
SGTC_2943 9068529 45.32 µM -0.290189618217196 0.387105159274957 no 2073 0.385835589064814 2898 3270634
SGTC_2757 clomiphene 4.22 µM -0.290431153501307 0.387000515585313 no 2074 0.385743206619862 3145 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_740 k014-0057 261 µM -0.290465831494636 0.386985492230113 no 2075 0.385729943508617 3021 4012779
SGTC_1859 st055998 20 µM -0.291521926034044 0.386528047429204 no 2076 0.385326088593796 3107 676301
SGTC_379 3970-0972 5.9 µM -0.292019496631703 0.386312580517385 no 2077 0.385135858599815 2960 2898042 YBL034C STU1
SGTC_547 1120-0019 610 nM -0.2930363348977 0.385872360120888 no 2078 0.384747189441273 2888 3676939
SGTC_173 1273-0061 2.693 µM -0.293726582790331 0.385573614375795 no 2079 0.384483419864647 3025 2847414 YPL266W DIM1
SGTC_184 1494-0393 24.714 µM -0.295770293299087 0.384689475952312 no 2080 0.383702755506365 2897 3090647
SGTC_3122 9126309 49.47 µM -0.296162638064313 0.384519810426865 no 2081 0.383552940035445 2993 17591206
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.296736637749974 0.384271629926402 no 2082 0.383333791639137 2947 4174840
SGTC_421 streptovitacin 30 mM -0.29766963885766 0.383868329079917 no 2083 0.382977659097655 3110 91467 include heat shock
SGTC_1929 genistein trimethyl ether 50.5 µM -0.29778422948479 0.38381880457757 no 2084 0.382933925929282 3119 136420
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.298169960127904 0.38365211101566 no 2085 0.382786723958195 3100 5393153
SGTC_1818 st052136 56.3 µM -0.298680454264995 0.383431533994936 no 2086 0.382591935954302 3021 674169
SGTC_1265 0819-1001 68.8 µM -0.298787188464415 0.383385420487204 no 2087 0.382551213398127 2927 3106768
SGTC_514 4466-0038 2.65 nM -0.299386631975656 0.38312646726198 no 2088 0.382322530411453 2967 5722064
SGTC_1526 st051518 75 µM -0.300478539093228 0.382654909251557 no 2089 0.381906081938659 2980 673993
SGTC_1708 st033234 31.827 µM -0.301240585537666 0.38232590998545 no 2090 0.381615521759734 3073 674664
SGTC_213 1246-0773 967 nM -0.302221289381979 0.381902634494391 no 2091 0.381241688012146 2973 6251622
SGTC_1936 st074407 74.3 µM -0.302507664266542 0.381779060612242 no 2092 0.381132545872852 2939 809813
SGTC_891 0929-0073 133 µM -0.302892384098739 0.381613068777578 no 2093 0.380985937753886 3069 5603632
SGTC_1493 4348-0038 111 µM -0.302921643074726 0.381600445543345 no 2094 0.380974788511644 2990 800424
SGTC_1430 4049-0248 69.1 µM -0.303690727398346 0.381268683788865 no 2095 0.380681761515872 3065 22774488
SGTC_2031 5180455 200 µM -0.303782798163512 0.381228972843529 no 2096 0.380646686435273 2942 29949
SGTC_2600 tangeritin 87.95 µM -0.303951641414581 0.381156152487444 no 2097 0.380582366822911 2918 68077 A bioactive flavone.
SGTC_363 0455-0021 3.06 µM -0.304018374123595 0.381127372517125 no 2098 0.380556946391247 2915 4597466
SGTC_1322 1348-1070 12 µM -0.306636731687872 0.3799986678748 no 2099 0.379559945895896 3049 6758089
SGTC_951 1171-0579 82.7 µM -0.307419375730604 0.379661488577263 no 2100 0.379262091037219 2889 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.307963404961091 0.37942716337415 no 2101 0.379055089247811 3173 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3288 9119690 36.221 µM -0.309086078459212 0.378943743589575 no 2102 0.37862802441591 2973 17595618 YKL019W RAM2
SGTC_256 clotrimazole 625 nM -0.310109810022767 0.378503092878802 no 2103 0.378238726224038 3015 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3041 9091929 49.47 µM -0.310793882729433 0.378208731487632 no 2104 0.377978660214148 3136 25236887
SGTC_2719 novobiocin 32.65 µM -0.311133889830013 0.378062450277947 no 2105 0.37784941923791 3087 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2020 4017018 200 µM -0.312766743025818 0.377360191945349 no 2106 0.377228941915298 3073 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2081 5214970 32.255 µM -0.313025721487058 0.377248847539709 no 2107 0.377130560262123 3070 2063512
SGTC_2360 9040895 200 µM -0.313241121658197 0.37715624682305 no 2108 0.377048739358667 3007 4914414
SGTC_2887 9044784 58.44 µM -0.313621760410917 0.376992627173336 no 2109 0.376904165198219 2970 6465546
SGTC_29 0299-0004 12.984 µM -0.314748431129668 0.376508451143687 no 2110 0.376476334488948 2997 16871 A napthoquinone isolated from Swertia calycina.
SGTC_833 3852-0053 558 µM -0.315405409958989 0.37622621033346 no 2111 0.37622692988021 3125 3123681
SGTC_1222 0366-0074 1.18 µM -0.315788744467662 0.376061558812219 no 2112 0.376081430954595 3075 286520
SGTC_2258 7960471 200 µM -0.316913909461265 0.375578403384881 no 2113 0.375654463708541 3035 2974708
SGTC_585 0kpi-0023 191 µM -0.317064115816495 0.375513918238957 no 2114 0.375597476290969 3097 64601
SGTC_747 3448-8087 38.7 µM -0.318412402028801 0.374935240898758 no 2115 0.375086065997482 3018 5168703
SGTC_1339 1486-1321 22.7 µM -0.319929422687103 0.374284480135483 no 2116 0.374510916534784 2993 3469382
SGTC_1625 st003711 30.1 µM -0.320887307868547 0.373873757620249 no 2117 0.374147896294651 3173 24207034 YER133W GLC7
SGTC_2499 avocadenofuran 51.48 µM -0.321137209944649 0.373766628004921 no 2118 0.374053206505163 2948 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1114 scopoletin 1.73284 µM -0.32206820418445 0.373367609355953 no 2119 0.373700512664406 3111 5280460 A coumarin with genotoxic properties.
SGTC_1485 3909-9022 254 µM -0.322428297918433 0.373213311684744 no 2120 0.373564124650899 3022 714516
SGTC_578 3460-0051 92 µM -0.322433715825204 0.373210990304397 no 2121 0.373562072701791 3088 2876744
SGTC_1787 fluconazole 80 µM -0.322884827809234 0.373017721016864 no 2122 0.373391233535372 3057 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2242 6630449 61.2675 µM -0.324584245515167 0.372289929103619 no 2123 0.372747876214152 3115 691249 YDR170C SEC7
SGTC_58 0957-0393 9 µM -0.324830204276484 0.372184632613423 no 2124 0.372654791688482 3104 6997992
SGTC_835 0312-0010 67.2 µM -0.32499109953429 0.372115757512981 no 2125 0.372593903964326 2944 1626196
SGTC_2306 7482397 179.52 µM -0.327699514667243 0.370956970721815 no 2126 0.371569435193377 3155 891448
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.328166785067125 0.370757168540519 no 2127 0.371392780050257 3108 5024745
SGTC_1446 4239-0190 62 µM -0.329122328623847 0.370348692061099 no 2128 0.371031613879802 3003 1340085
SGTC_347 4534-1311 26.2 µM -0.330876465665286 0.369599212941699 no 2129 0.370368899662689 2946 2862016
SGTC_3113 9123498 49.47 µM -0.331603110233572 0.369288888965604 no 2130 0.370094485363653 3039 8897275
SGTC_2054 5233173 129 µM -0.33265481488752 0.368839894280465 no 2131 0.369697430602499 3143 6889
SGTC_811 0416-0114 265 µM -0.333295831707322 0.368566318544297 no 2132 0.369455492754885 3088 6612453
SGTC_149 3970-0822 46.1 µM -0.334151282621995 0.368201329534887 no 2133 0.369132701950519 3062 3114250 YBL034C STU1
SGTC_1944 st076371 56.9 µM -0.33861424981461 0.366299083335385 no 2134 0.367450173179201 2977 24208455
SGTC_2705 st078069 42.8 µM -0.339561160932059 0.365895902625525 no 2135 0.367093515503707 3068 1530061
SGTC_374 0880-0231 82.3 µM -0.341104243066769 0.365239198531654 no 2136 0.366512553540721 3066 6833587
SGTC_168 3970-0862 530.542 µM -0.34166812479149 0.364999320472766 no 2137 0.366300331367381 3077 3135186
SGTC_1581 himbacine 57.9 µM -0.342373784061741 0.364699203973043 no 2138 0.366034807486676 2999 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_711 k292-0785 179 µM -0.342571744107176 0.364615026556118 no 2139 0.365960331042646 2978 4146315
SGTC_2838 9002687 71.43 µM -0.344066079062777 0.363979809924043 no 2140 0.36539829611978 2965 6457060
SGTC_1150 3909-7983 10.9 µM -0.349367234207364 0.361729402024029 no 2141 0.363406814358622 3040 23965914
SGTC_1020 4335-0961 93.3 µM -0.349817256991599 0.361538580363141 no 2142 0.363237923566867 2973 669075
SGTC_903 1134-0042 114 µM -0.350421219473116 0.361282538287386 no 2143 0.363011301938295 3039 701009
SGTC_1748 st037455 53.6035 µM -0.352412023215144 0.360439003247012 no 2144 0.362264643207432 3193 580690
SGTC_2194 5927483 104.545 µM -0.352454624720797 0.36042095971906 no 2145 0.362248671059687 3011 760979
SGTC_3110 9122132 49.47 µM -0.353072864476804 0.360159144206213 no 2146 0.362016907743974 3195 918317
SGTC_1175 0741-0056 27.6 µM -0.354593336584981 0.359515525636902 no 2147 0.36144713441452 3218 765927
SGTC_2923 7992654 58.14 µM -0.354816545702594 0.359421074303414 no 2148 0.36136351608518 3061 2985126
SGTC_1316 1272-0050 65.9 µM -0.355421728197491 0.359165033484229 no 2149 0.361136836679433 3026 7340392
SGTC_1495 4469-0029 237 µM -0.357639554596429 0.35822725605295 no 2150 0.360306536635293 3037 793680
SGTC_1927 st060202 13.8 µM -0.357887635535501 0.358122411474719 no 2151 0.360213702061788 3130 688887
SGTC_2833 9001315 45.46 µM -0.358809588758673 0.357732867143227 no 2152 0.359868769453314 2998 2989378
SGTC_316 k060-0003 58.6 µM -0.359349469573895 0.35750482505889 no 2153 0.359666835474842 3154 6152314
SGTC_869 0564-0080 44.1 µM -0.359663477239265 0.357372213690046 no 2154 0.359549403831134 3075 6843321
SGTC_2132 5317594 122.667 µM -0.359665431522417 0.357371388413263 no 2155 0.359548673015704 3005 794577
SGTC_3037 9091026 49.47 µM -0.359699126733522 0.357357159323506 no 2156 0.359536072578408 3124 25236398 YIL048W NEO1
SGTC_2389 9091542 195.52 µM -0.360310555835006 0.357098994502739 no 2157 0.359307453154485 3084 3626624 YOL127W RPL25
SGTC_2124 5246320 200 µM -0.360907754079121 0.35684690154611 no 2158 0.359084203404914 3118 579342
SGTC_3079 9117512 49.47 µM -0.361708859362521 0.356508832280784 no 2159 0.358784802954709 3076 7185044
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.361921241249931 0.356419225263362 no 2160 0.358705443117654 2980 688667
SGTC_232 clozapine 119 µM -0.363183887981269 0.355886659967536 no 2161 0.358233761317852 3062 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1423 4048-0112 5.59 µM -0.363840341796692 0.355609888673028 no 2162 0.35798861793783 3127 X1423
SGTC_2931 9014674 55.67 µM -0.366829051581946 0.354350765449614 no 2163 0.356873267992134 3010 2996810
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.368344342822345 0.353712990142424 no 2164 0.356308246182556 3055 641818 YHR062C RPP1
SGTC_952 1185-0122 232 µM -0.369560119366714 0.353201575047993 no 2165 0.355855135321488 3011 678600
SGTC_931 2812-0076 566 µM -0.373808706963202 0.351416497589839 no 2166 0.354273320570406 3019 3450959
SGTC_405 ebelactone b 50 µM -0.374627239888243 0.351072959285194 no 2167 0.35396885575886 3079 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_35 0133-0054 64.071 µM -0.375425578758635 0.350738013630558 no 2168 0.353671992330149 3102 99677
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.377083731741371 0.350042701049865 no 2169 0.35305569027875 3006 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2268 7933382 153.85 µM -0.378664332111343 0.34938037624589 no 2170 0.352468571575012 3089 935025 YOR257W CDC31
SGTC_1663 st014140 55.4 µM -0.378726580439724 0.349354301467509 no 2171 0.35244545643016 3119 4207120
SGTC_1072 oxiconazole 14.9 nM -0.379054773400602 0.349216838710952 no 2172 0.352323595056014 3128 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3350 9150499 3.57 µM -0.379538463868881 0.349014282292908 no 2173 0.35214402351786 3035 4910996 YPR165W RHO1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.3808553737465 0.348463014359594 no 2174 0.351655283921041 3131 229346 A bile salt which induces apoptosis.
SGTC_2445 5742597 35.57 µM -0.383142500767973 0.347506367348707 no 2175 0.350807054265157 3058 1774255
SGTC_743 1275-0778 158 µM -0.383148136242125 0.347504011369399 no 2176 0.350804965145862 3160 2849257 YMR203W TOM40
SGTC_566 0958-0068 16.5 µM -0.385296905304771 0.346606122110124 no 2177 0.350008727048632 3240 6815365
SGTC_497 capsazepine 133 µM -0.385989404321369 0.346316936201876 no 2178 0.349752258010999 3093 2733484 A calcium channel blocker.
SGTC_2198 6589944 200 µM -0.386462518401645 0.346119416400401 no 2179 0.349577078231824 3127 5290268
SGTC_2014 4013930 200 µM -0.386676898359905 0.346029928958098 no 2180 0.349497710384396 3185 64556
SGTC_872 0588-0139 234 µM -0.386812546569843 0.34597331051587 no 2181 0.349447494039522 3090 2047100
SGTC_1596 piperlongumine 63 µM -0.388000740311138 0.345477515573563 no 2182 0.349007742875056 3221 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_290 2043-6722 48.1 µM -0.389257935542137 0.344953217040194 no 2183 0.348542674916983 3188 773758 YLR208W SEC13
SGTC_796 1234-0020 70.7 µM -0.390932552848312 0.344255299778447 no 2184 0.347923545600875 3081 46495034
SGTC_1481 3346-2004 36 µM -0.392092509503341 0.343772184218732 no 2185 0.347494930932946 3186 2770522
SGTC_214 4373-3496 70 µM -0.392245515162585 0.34370847722462 no 2186 0.347438408471431 3166 3779166
SGTC_983 1491-0821 12.2 µM -0.392278625035302 0.343694691844973 no 2187 0.347426177661063 3197 46495113
SGTC_2161 5662504 8.5105 µM -0.394490070738209 0.342774422157833 no 2188 0.346609628257711 3112 2859334
SGTC_2876 9059903 25.97 µM -0.394828711823669 0.342633582429206 no 2189 0.346484651941785 3200 6916095
SGTC_2508 celastrol 40.54 µM -0.395454297740196 0.342373460814633 no 2190 0.346253821891739 3141 122724 Celastrol is a natural product and antioxidant.
SGTC_1361 1608-0041 5.61 µM -0.397379757262832 0.341573315128412 no 2191 0.345543720306188 3107 X1361
SGTC_2089 5281248 129.67 µM -0.398277971397296 0.341200295574539 no 2192 0.345212648253735 3118 2737878
SGTC_2723 salbutamol 83.58 µM -0.398754724890866 0.341002367502643 no 2193 0.345036970145275 3192 9884233 β2-adrenoceptor agonist
SGTC_2136 5328288 199.296 µM -0.399221678204883 0.340808550462752 no 2194 0.344864935660541 3111 262395
SGTC_1933 st074711 15.9 µM -0.399301257992174 0.340775523686129 no 2195 0.344835620150212 3141 17250958
SGTC_917 harmaline 728.087 nM -0.399715269558493 0.340603722521756 no 2196 0.344683122079365 3189 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1915 st067105 30.6 µM -0.399897678169626 0.340528039446912 no 2197 0.344615941235588 3161 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3094 9117742 49.47 µM -0.400116737129459 0.340437158278381 no 2198 0.344535268594438 3064 17149698
SGTC_1238 0333-0287 48.8 µM -0.401158847565098 0.340004944032958 no 2199 0.344151588426525 3135 7226
SGTC_2328 6201408 200 µM -0.40165909169329 0.33979754291931 no 2200 0.343967467433325 3208 2890418
SGTC_265 mycophenolic acid 32.932 µM -0.402986093851347 0.339247603147493 no 2201 0.343479227314519 3347 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_906 1165-0455 526 µM -0.403415878744223 0.339069563863923 no 2202 0.343321153709821 3121 3252859
SGTC_2266 7929956 200 µM -0.405215429654962 0.338324486771847 no 2203 0.342659582121744 3126 2967153
SGTC_1013 4112-3890 241 µM -0.405652269109645 0.338143715250504 no 2204 0.342499058853741 3059 705171
SGTC_189 3970-0742 2.116 µM -0.407506777479963 0.337376704291029 no 2205 0.341817908678667 3258 2891807
SGTC_2726 cimetidine 79.27 µM -0.407770773340464 0.337267572387174 no 2206 0.341720986322909 3140 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2855 9016525 58.44 µM -0.409314605646345 0.33662964979626 no 2207 0.341154399158179 3088 43811474
SGTC_2143 5623677 140.463 µM -0.409370766940459 0.336606452392439 no 2208 0.34113379467768 3207 5375313
SGTC_202 3594-0513 34.79 µM -0.409708966833707 0.336466772187871 no 2209 0.341009725768262 3145 708429
SGTC_834 0312-0008 75.7 µM -0.411617960150246 0.335678760988716 no 2210 0.340309732706569 3143 6385573 YIL048W NEO1
SGTC_1080 nisoldipine 24.4 µM -0.41175054058184 0.335624060037989 no 2211 0.340261138272581 3059 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_794 k038-0031 316 µM -0.413460246771794 0.334918970085036 no 2212 0.339634721089188 3241 6624242
SGTC_2572 astragaloside iv 100 µM -0.414507761068725 0.334487257926971 no 2213 0.339251142183357 3272 45006101 An anti-inflammatory agent.
SGTC_384 k007-0144 5.16 µM -0.414651092714414 0.334428203645838 no 2214 0.339198669927965 3173 6824886
SGTC_3192 9110362 49.47 µM -0.414912292061867 0.334320597056782 no 2215 0.339103055527863 3198 16649480
SGTC_2029 5175081 200 µM -0.416172702383542 0.333801535869818 no 2216 0.338641816582862 3135 1380876
SGTC_1184 1269-1718 139 µM -0.416577698133079 0.333634818269978 no 2217 0.338493662344895 3269 5403821
SGTC_508 roscovitine 141 µM -0.41661228499771 0.333620582015096 no 2218 0.338481011047784 3153 160355 A CDKinase inhibitor.
SGTC_150 3970-0969 77.2 µM -0.416715722476899 0.333578007676896 no 2219 0.33844317643428 3249 6615640
SGTC_1000 4048-0884 8.67 µM -0.417457459254679 0.333272775421051 no 2220 0.338171917112839 3250 13040088
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.418493635537917 0.332846563139337 no 2221 0.337793119440421 3163 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1925 st057770 10.1 µM -0.418562897495043 0.332818081184176 no 2222 0.337767805017533 3133 5989122
SGTC_2903 5923464 63.88 µM -0.418743643351731 0.332743759278228 no 2223 0.337701748009773 3230 2876576
SGTC_1112 tnp00069 1.16933 µM -0.419015185824561 0.332632114555229 no 2224 0.337602517051289 3231 145826
SGTC_2824 7998404 51.95 µM -0.419639306165451 0.33237556367101 no 2225 0.337374484819247 3112 837851
SGTC_1788 fluconazole 20 µM -0.420233664280109 0.332131319830301 no 2226 0.337157382197465 3230 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1294 1000-1494 117 µM -0.420470956488629 0.33203382755022 no 2227 0.337070721040966 3169 712797 YDL207W GLE1
SGTC_2299 7976368 114.88 µM -0.420694243764034 0.331942099625156 no 2228 0.336989182502244 3251 2979718
SGTC_2881 9058953 51.95 µM -0.423134506454321 0.330940280711783 no 2229 0.336098563823993 3110 17122249
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.42481809897503 0.330249807640835 no 2230 0.335484641377371 3261 368090
SGTC_812 4251-0442 148 µM -0.424892777340157 0.330219193996269 no 2231 0.335457420048337 3264 5723007
SGTC_83 0170-0301 39.027 µM -0.42491078053501 0.330211813937655 no 2232 0.335450857756286 3216 3089716
SGTC_204 PMA1.184 62.41 µM -0.425190477318501 0.330097166182556 no 2233 0.335348912746737 3184 2252213 YGL008C PMA1
SGTC_3066 9117245 49.47 µM -0.427726160357852 0.329058518328197 no 2234 0.334425250729955 3170 17176980
SGTC_2074 5212007 75.395 µM -0.42879488399654 0.328621150031521 no 2235 0.334036251157357 3257 758611
SGTC_3175 9106517 49.47 µM -0.429002379068684 0.328536261189032 no 2236 0.333960746673906 3234 41468073
SGTC_2440 5628896 157.78 µM -0.432003639235603 0.327309399460939 no 2237 0.332869384085438 3143 5522048
SGTC_761 k216-0224 480 µM -0.432552232116675 0.327085345475317 no 2238 0.332670049259818 3326 1340404
SGTC_701 4424-0219 185 µM -0.433196373063766 0.326822347682023 no 2239 0.332436056789684 3330 2911779
SGTC_2449 5812982 45.77 µM -0.433417825924704 0.326731950044075 no 2240 0.332355626270717 3250 776185
SGTC_1071 trifluoperazine 6.31 µM -0.433688876816563 0.326621320202302 no 2241 0.332257192513521 3293 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2206 7254556 146.969 µM -0.433978269977752 0.326503220761479 no 2242 0.332152110422686 3211 4398905
SGTC_539 4859-0462 2.54 µM -0.436183189677035 0.325603979212177 no 2243 0.331351911738955 3292 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3185 9108267 49.47 µM -0.436458206614098 0.325491888933771 no 2244 0.331252157826908 3259 4910486
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.43887621326877 0.324507047954626 no 2245 0.330375616581822 3205 688664
SGTC_65 0798-0905 34.986 µM -0.43888028348972 0.32450539120748 no 2246 0.330374141886077 3507 3602145
SGTC_2179 6298986 200 µM -0.439387658669402 0.32429889587478 no 2247 0.330190333678262 3276 738374
SGTC_528 3492-0019 172 µM -0.439685478756576 0.324177711994436 no 2248 0.330082460653795 3268 2869262
SGTC_1911 st060208 74.3 µM -0.440260442069794 0.323943810405577 no 2249 0.329874243907133 3253 688783
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.440625702417228 0.323795254450761 no 2250 0.329741996192182 3147 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1880 MG-132 525 µM -0.441018219437525 0.323635644152434 no 2251 0.329599903534869 3286 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3074 9116018 49.47 µM -0.441089153846954 0.323606803354125 no 2252 0.329574227631792 3143 17027303
SGTC_9 0092-0002 10.449 µM -0.441479876970482 0.323447960564779 no 2253 0.329432813224997 3259 759368
SGTC_1366 1683-0113 21.9 µM -0.442207632493292 0.323152187946562 no 2254 0.32916948173185 3178 708623
SGTC_629 3448-6466 76.7 µM -0.444474182629756 0.32223173896604 no 2255 0.328349895264086 3226 573744
SGTC_2092 5303694 80.6725 µM -0.444606298083779 0.322178120244037 no 2256 0.328302147623898 3183 1963699
SGTC_2987 9018338 71.43 µM -0.44482685841356 0.322088614639358 no 2257 0.328222441508777 3331 5055682
SGTC_562 3772-2733 112 µM -0.445553960063797 0.321793622556115 no 2258 0.327959736834916 3301 2876874 YIL048W NEO1
SGTC_2495 cafestol 54.53 µM -0.445740981585828 0.321717764287374 no 2259 0.327892178980529 3325 16667697 An anti-infammatory.
SGTC_2414 st077232 92.9 µM -0.446258262364451 0.32150798744407 no 2260 0.327705350786569 3118 729801
SGTC_3276 9139060 49.47 µM -0.44666257124164 0.321344064582228 no 2261 0.327559355090427 3239 4870619
SGTC_2904 7225135 42.03 µM -0.446693242179435 0.321331630786461 no 2262 0.327548280908515 3306 4446116
SGTC_1745 st081495 74 µM -0.446729508535263 0.321316928903511 no 2263 0.327535186616449 3267 13842402 YBL026W LSM2
SGTC_1011 4112-3381 17.4 µM -0.446819617384838 0.321280401224565 no 2264 0.327502652928956 3346 2877139
SGTC_1956 st077085 54 µM -0.449441695967308 0.320218240085774 no 2265 0.326556529221548 3216 24208685
SGTC_2253 7938677 135.83 µM -0.449696468591366 0.320115114160255 no 2266 0.326464659016907 3330 2301972
SGTC_2656 pseudo-anisatin 100 µM -0.451941649023407 0.319206919818533 no 2267 0.325655509630922 3219 6708809 A neurotoxin.
SGTC_1128 3448-9350 235 µM -0.452113530061038 0.319137437093854 no 2268 0.325593598524379 3229 619386
SGTC_792 4534-1957 155 µM -0.452978507119056 0.318787867524692 no 2269 0.325282109072099 3184 1717904
SGTC_2520 obtusaquinone 4.71 µM -0.453434925020429 0.318603476923948 no 2270 0.325117796237908 3359 5967872
SGTC_2553 4-methylesculetin 85.09 µM -0.455217304179448 0.317883834940832 no 2271 0.324476456319971 3256 5319502
SGTC_362 0310-0100 9.03 µM -0.456049861555696 0.317547922223333 no 2272 0.324177061669931 3314 790235
SGTC_2516 gossypol 71.55 µM -0.457365638332609 0.317017350784631 no 2273 0.323704129062013 3342 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_339 3091-4833 71.4 µM -0.457404334391416 0.317001752742592 no 2274 0.323690224754166 3250 3240077
SGTC_963 1269-2853 151 µM -0.457595151247134 0.316924840897023 no 2275 0.323621663843587 3190 3668223
SGTC_1954 st077032 68.9 µM -0.459046843876052 0.316339971715034 no 2276 0.323100263680685 3262 698907
SGTC_1824 st053723 68.6 µM -0.459079134654612 0.316326967370332 no 2277 0.323088669842701 3259 675225
SGTC_3170 9103054 49.47 µM -0.460606496581817 0.315712118304357 no 2278 0.322540474889217 3272 16432970
SGTC_965 1291-5240 308 µM -0.460808508360846 0.31563083533039 no 2279 0.322467998432675 3332 2834598
SGTC_2905 7799065 20.05 µM -0.460929228288754 0.31558226581184 no 2280 0.322424690551718 3339 1296806
SGTC_1942 st076330 65.2 µM -0.461085268109773 0.315519490681464 no 2281 0.322368715344628 3349 24208414
SGTC_1762 st045503 25.4615 µM -0.461473292038422 0.315363410964622 no 2282 0.322229539363417 3281 4645554
SGTC_407 eburnamonine 100 µM -0.46170050320097 0.315272032268292 no 2283 0.322148055089004 3205 3195
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.461947078801974 0.315172878460376 no 2284 0.322059635857044 3302 521171
SGTC_1899 st063254 59.6 µM -0.464196930253983 0.314268776344243 no 2285 0.321253330172269 3162 3093813
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.464248181692311 0.314248193917406 no 2286 0.321234972385005 3277 5355888
SGTC_1983 st071813 46.9 µM -0.4646484053643 0.31408748513825 no 2287 0.321091631024256 3257 11838595
SGTC_2972 9093619 59.92 µM -0.464692413255038 0.314069816034123 no 2288 0.321075871086658 3161 25236256
SGTC_2930 9013230 14.89 µM -0.465297361830513 0.313826973271891 no 2289 0.320859261891195 3311 2995857
SGTC_420 mitomycin C 81.9 mM -0.46550314732998 0.313744383764999 no 2290 0.320785591783062 3203 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_115 0527-0192 112.043 µM -0.46850140791023 0.312542128659311 no 2291 0.319713032201479 3331 4233931
SGTC_1089 terbinafine 2.25 µM -0.469131612636161 0.312289679484062 no 2292 0.319487782015505 3324 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_579 4491-1009 110 µM -0.469198219538268 0.312263003050023 no 2293 0.319463979010942 3370 1271041
SGTC_1303 1160-0052 261 µM -0.469274007163923 0.312232650882197 no 2294 0.319436896037858 3304 3562476
SGTC_1573 oleylamine 1.06 µM -0.470677735281917 0.311670702707977 no 2295 0.318935443149894 3270 5356789 An amine of the fatty acid oleic acid.
SGTC_2784 7567673 72.73 µM -0.472361983875492 0.310997033476901 no 2296 0.318334217278014 3335 3471247
SGTC_1916 st067606 49.2 µM -0.47241508786056 0.310975803115216 no 2297 0.318315268527829 3266 19590279
SGTC_105 0111-0055 734.78 µM -0.472548124771511 0.310922619252505 no 2298 0.318267799917959 3289 5179370
SGTC_754 3474-0146 171 µM -0.473575524536678 0.310512031069594 no 2299 0.317901316206389 3187 24762078
SGTC_2098 5376439 882.5 nM -0.474148522424257 0.310283141693718 no 2300 0.317696999580632 3313 2844116
SGTC_1193 1488-0126 41.5 µM -0.474148657910422 0.310283087581184 no 2301 0.317696951276236 3246 1384710
SGTC_2006 4011487 200 µM -0.474795398156131 0.310024829405017 no 2302 0.31746640667545 3371 45595294
SGTC_2975 9084847 53.72 µM -0.475773420796316 0.309634460596024 no 2303 0.31711790375151 3287 27211724
SGTC_3290 9121031 71.43 µM -0.476305062750591 0.309422350581745 no 2304 0.316928529538162 3262 17014854
SGTC_2093 5331342 194.4 µM -0.477732651278712 0.308853097606267 no 2305 0.316420250867213 3353 33839
SGTC_1527 coumarin 137 µM -0.48046611651983 0.307764405672315 no 2306 0.315447995474679 3376 323 A hepatotoxic, DNA x-linker.
SGTC_587 k089-0003 57 µM -0.480740490016518 0.30765522065101 no 2307 0.315350475034236 3326 9659696
SGTC_2512 diallyl trisulfide 49.23 µM -0.480972536420306 0.307562892696299 no 2308 0.315268008930928 3335 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_263 alizarin 107.927 µM -0.482282891745895 0.307041749890576 no 2309 0.314802499477474 3287 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3225 9130819 49.47 µM -0.483750029678568 0.30645871517769 no 2310 0.314281641324909 3353 4547121
SGTC_1666 st014829 29 µM -0.484292311535557 0.306243338391574 no 2311 0.31408921581675 3278 3858230
SGTC_3317 9138495 8.753 µM -0.485057688775597 0.305939469269843 no 2312 0.313817712228209 3323 17020139
SGTC_989 1501-0895 10.3 µM -0.486766879439107 0.305261370746114 no 2313 0.313211772064674 3378 2830112
SGTC_486 niguldipine 82 µM -0.487609183022903 0.304927443553969 no 2314 0.312913344912882 3278 1236 A calcium channel blocker.
SGTC_1816 st051957 91.6 µM -0.488001995963316 0.304771770266548 no 2315 0.312774213648542 3302 674121
SGTC_3197 9113331 49.47 µM -0.489554720852929 0.30415676553031 no 2316 0.31222451187114 3431 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1289 0976-0073 69.1 µM -0.489809299433354 0.304055984589437 no 2317 0.312134424789033 3356 3391136
SGTC_2934 9036370 36.88 µM -0.490115267400271 0.303934879644987 no 2318 0.312026167537062 3300 6462800
SGTC_977 1348-1378 135 µM -0.491081525452083 0.303552567096886 no 2319 0.311684393784173 3247 X977
SGTC_2980 9014342 25.29 µM -0.491984870295511 0.303195341338985 no 2320 0.311365019613055 3401 2996599
SGTC_1328 1441-0025 69.2 µM -0.492322114836702 0.303062026922753 no 2321 0.311245824442087 3299 4562601
SGTC_836 0330-0104 1.35 µM -0.492551345695921 0.302971425816663 no 2322 0.31116481675009 3317 46494820
SGTC_3299 9121982 43.1275 µM -0.492610590171346 0.30294801202709 no 2323 0.311143881884155 3277 17594604 YPL160W CDC60
SGTC_602 3130-1533 38.1 µM -0.493195129731927 0.302717041741875 no 2324 0.310937359397076 3380 720941
SGTC_1892 st058411 7.36 µM -0.493514123111643 0.302591030528796 no 2325 0.310824681596996 3339 3934738
SGTC_195 4234-0266 16.654 µM -0.493783164133824 0.302484770157662 no 2326 0.310729662219957 3274 2303354
SGTC_606 k015-0008 38.6 µM -0.494974458209806 0.302014458150137 no 2327 0.310309075086571 3387 1970475
SGTC_2251 lansoprazole 556 µM -0.495587068994513 0.301772732953905 no 2328 0.310092888959368 3187 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1840 st055363 71 µM -0.495901577157924 0.301648667485707 no 2329 0.309981926684293 3304 676033
SGTC_1188 1403-0014 4.57 µM -0.497637238041294 0.300964406441088 no 2330 0.309369876069781 3293 9614867
SGTC_776 4476-4378 112 µM -0.499275706421789 0.300319105152714 no 2331 0.308792583538018 3359 2892008
SGTC_2058 5236698 133 µM -0.499378048709487 0.300278818991515 no 2332 0.3087565402465 3271 766665
SGTC_247 mechlorethamine 29.705 µM -0.501398515741055 0.2994839802085 no 2333 0.30804534209134 3298 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3273 9137859 49.47 µM -0.501409023663462 0.299479848953209 no 2334 0.308041645215541 3374 2377234
SGTC_1931 st074438 57.1 µM -0.50295574917686 0.298872026167104 no 2335 0.307497692011637 3354 2787313
SGTC_785 1270-0111 65.3 µM -0.503107477011014 0.298812431284567 no 2336 0.307444355057449 3308 6741994
SGTC_3130 9127414 49.47 µM -0.503216912991161 0.298769450932479 no 2337 0.307405887505044 3352 1494646
SGTC_479 n-linoleoylglycine 10 µM -0.505059877176299 0.298046059851946 no 2338 0.306758390527867 3312 6433346 An anti-infammatory.
SGTC_253 dyclonine 31.25 µM -0.505473551483744 0.297883796230961 no 2339 0.306613135181599 3375 3180 An oral anasthetic.
SGTC_1432 4049-0298 68.4 µM -0.505637129410224 0.297819643954075 no 2340 0.306555705696095 3371 741646
SGTC_2714 st079313 56.9 µM -0.505788803507582 0.297760165772179 no 2341 0.306502459690657 3308 2939799
SGTC_1444 4112-3581 28 µM -0.506231602169951 0.297586555665867 no 2342 0.306347036217257 3352 2877249
SGTC_3009 9080819 71.4286 µM -0.507621875631678 0.297041765274747 no 2343 0.305859273140516 3338 17027216
SGTC_25 0118-0223 35.662 µM -0.507707926304829 0.297008060587044 no 2344 0.305829094452327 3424 5333628
SGTC_310 1273-0058 1.06 µM -0.507788994071123 0.29697630922553 no 2345 0.305800664517223 3388 2734232
SGTC_1646 st011709 75.6 µM -0.510121364909363 0.296063468285476 no 2346 0.3049832190712 3388 5757843
SGTC_1836 st055642 81 µM -0.511750984653506 0.295426434573695 no 2347 0.304412649289557 3294 8571
SGTC_370 0180-0345 38.7 µM -0.512729692444823 0.295044151778308 no 2348 0.304070208256568 3260 3989527
SGTC_2540 epiandrosterone 100 µM -0.513696661153024 0.294666678194988 no 2349 0.303732043341485 3427 441302 A steroid.
SGTC_1534 6-azauridine 81.6 µM -0.514493037296845 0.294355965850295 no 2350 0.303453663558545 3315 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2725 haloperidol 53.21 µM -0.516604161417827 0.293533027333114 no 2351 0.302716255071859 3323 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1221 2958-7315 257 µM -0.518027518913343 0.292978789553767 no 2352 0.302219534638791 3392 4562705
SGTC_1709 st033179 39.1045 µM -0.518098615563048 0.292951118136245 no 2353 0.302194733067476 3336 573381
SGTC_428 3448-4153 16.5 µM -0.51866451230527 0.292730909593543 no 2354 0.301997356510404 3218 3834874
SGTC_1236 0330-0013 258 µM -0.520163887075653 0.292147826839371 no 2355 0.301474676561989 3316 4617066
SGTC_597 k018-0003 82.8 µM -0.521358199753391 0.291683764894729 no 2356 0.301058632353453 3420 6786234
SGTC_2307 7538926 6.34 µM -0.522304009404443 0.291316505208549 no 2357 0.300729339027075 3319 96582
SGTC_3072 9116419 49.47 µM -0.523586800912362 0.29081873995549 no 2358 0.300282981921659 3351 17170162
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.523918472815486 0.290690105082956 no 2359 0.300167622889029 3395 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.524618112945552 0.290418845565576 no 2360 0.299924346321657 3274 6708514
SGTC_1352 1496-0991 99 µM -0.525102479746196 0.290231119744924 no 2361 0.299755976182252 3339 3000039
SGTC_1157 4092-0394 27.6 µM -0.525491198305107 0.290080505397378 no 2362 0.299620885177512 3500 3659885
SGTC_1847 st056231 15 µM -0.525767198989083 0.289973587384138 no 2363 0.299524983662351 3361 5393180
SGTC_2706 st078239 82.5 µM -0.525968748746514 0.289895522080039 no 2364 0.299454960282185 3425 15434492
SGTC_236 1509-0011 5.31 µM -0.527178988966166 0.289426972937354 no 2365 0.299034649014413 3486 3107280
SGTC_2019 4016004 108 µM -0.528239742168418 0.289016591044084 no 2366 0.298666474389938 3345 45595336
SGTC_1605 st000082 49.1 µM -0.528355693871316 0.288971748502468 no 2367 0.2986262414534 3416 1114022
SGTC_523 1934-0222 13.7 µM -0.528831838476913 0.288787641212549 no 2368 0.298461054583726 3310 1361595
SGTC_2119 5528445 120.635 µM -0.529536434057426 0.288515301849844 no 2369 0.298216688481336 3437 791935
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.530503892229857 0.288141558474474 no 2370 0.297881305554763 3372 6708561
SGTC_2485 5633444 17.78 µM -0.531683345758468 0.287686227405832 no 2371 0.297472664273628 3380 5724239
SGTC_337 1315-0038 354 µM -0.531698806138366 0.287680261144781 no 2372 0.297467309468126 3360 1626437
SGTC_2936 9038235 15.59 µM -0.532033154046176 0.287551248422732 no 2373 0.297351516615206 3369 4749415
SGTC_1934 st074720 32.6 µM -0.532469350005146 0.287382977366784 no 2374 0.29720048225635 3358 17250992
SGTC_3123 9126162 49.47 µM -0.532665183205124 0.287307446063367 no 2375 0.297132685741155 3367 25239884
SGTC_1633 st005664 67.9 µM -0.533434281759735 0.287010901804021 no 2376 0.296866495948325 3329 2063822
SGTC_2560 caryophyllene 100 µM -0.534165636125487 0.28672904526012 no 2377 0.296613470931762 3350 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2381 9035592 200 µM -0.534246715969515 0.28669780599405 no 2378 0.296585426005176 3368 4749657
SGTC_768 0384-0033 77.3 µM -0.534510034337695 0.286596363150237 no 2379 0.296494354482044 3319 3965305 YMR134W ERG29
SGTC_2190 6049624 200 µM -0.534572178952095 0.286572424552431 no 2380 0.29647286296011 3374 2265554
SGTC_1440 4100-1550 40 µM -0.535013182079774 0.28640257390689 no 2381 0.296320371007772 3395 742806
SGTC_2854 9024559 71.43 µM -0.535924727934901 0.286051647080484 no 2382 0.296005286827718 3376 3163529
SGTC_2883 9059145 45.46 µM -0.536185646588896 0.285951236270335 no 2383 0.29591512622352 3316 16476510
SGTC_690 glyoxal 20.3 µM -0.536575162602517 0.28580136778941 no 2384 0.295780552191599 3371 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_642 0335-0876 158 µM -0.537572645257869 0.285417751126384 no 2385 0.295436059798696 3393 6812350
SGTC_2055 5235184 200 µM -0.538658241746438 0.285000526072773 no 2386 0.295061346127591 3441 2836034
SGTC_3154 9100113 49.47 µM -0.539330392572885 0.284742345603208 no 2387 0.294829450642253 3335 25237525
SGTC_3032 9089427 49.47 µM -0.539865658577446 0.284536823962837 no 2388 0.294644841236684 3410 17173707
SGTC_857 0438-0306 1.35 µM -0.54111750859964 0.28405643831161 no 2389 0.294213295457288 3460 4686136
SGTC_2156 5649887 115 µM -0.541392042037133 0.283951140586007 no 2390 0.294118695581355 3443 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2068 5226020 147 µM -0.542242022781909 0.283625247647229 no 2391 0.293825894846086 3383 1810509
SGTC_3298 9116858 71.43 µM -0.543782187940217 0.283035186529248 no 2392 0.293295683730181 3441 2506942
SGTC_2978 9011784 42.97 µM -0.545176895417714 0.282501361402521 no 2393 0.292815930243371 3391 2994934
SGTC_139 0099-0334 718.624 µM -0.545417728573893 0.282409231406511 no 2394 0.292733125008573 3439 97690
SGTC_1336 1486-0901 104 µM -0.545758361048724 0.28227894816335 no 2395 0.292616024523179 3408 5006114
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.546151650345776 0.282128561009828 no 2396 0.292480849082676 3442 279621
SGTC_2703 st077852 53.4 µM -0.548141722168922 0.281368183291631 no 2397 0.291797297164796 3436 6281836
SGTC_3151 9099821 49.47 µM -0.550288731666729 0.280548952737104 no 2398 0.29106067590066 3422 17174189
SGTC_2652 actinonin 100 µM -0.553008883962566 0.279512689677177 no 2399 0.290128663427726 3404 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1335 1486-0900 202 µM -0.555670732763245 0.278500440430278 no 2400 0.289217983814113 3451 X1335
SGTC_264 promethazine 12.5 mM -0.55692857088616 0.278022731223595 no 2401 0.288788116529413 3523 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2993 9054257 71.4286 µM -0.559793602892888 0.276936127166718 no 2402 0.287810113780822 3426 6470217 YGL055W OLE1
SGTC_1486 3970-0793 4.53 µM -0.560158402682277 0.276797921046599 no 2403 0.287685698677533 3474 2844330
SGTC_1164 k060-0068 93.7 µM -0.560267317269501 0.276756664791965 no 2404 0.287648558244557 3471 5963676
SGTC_2892 9047358 58.44 µM -0.560549520441675 0.276649781778807 no 2405 0.287552336059326 3375 6466771
SGTC_774 k060-0086 136 µM -0.560595337119024 0.276632430854712 no 2406 0.287536715485164 3502 5911235
SGTC_342 k048-0088 23.3 µM -0.560958555615445 0.276494897710255 no 2407 0.287412895269117 3372 6820570
SGTC_2236 dapsone 200 µM -0.56157903695396 0.276260029247443 no 2408 0.287201433197023 3465 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1693 xanthone 101.9 µM -0.561987530394197 0.27610545722316 no 2409 0.287062257507401 3422 7020 An insecticide.
SGTC_709 3807-1509 243 µM -0.562700442147557 0.275835796470172 no 2410 0.286819441565028 3478 1886677 YPL242C IQG1
SGTC_883 0850-0245 24.6 µM -0.563982544607293 0.275351163690197 no 2411 0.286383005821061 3505 6823229 YPR165W RHO1
SGTC_21 0849-0113 22.993 µM -0.567574041209186 0.273995818428159 no 2412 0.285162118924045 3426 1560156
SGTC_2963 9082507 9 µM -0.567853764437472 0.273890396103521 no 2413 0.285067134533243 3471 16459611
SGTC_1677 st019204 53.9 µM -0.567903769013433 0.273871552450071 no 2414 0.285050156287875 3425 3945625
SGTC_636 0kpi-0074 126 µM -0.568127973697259 0.273787071355851 no 2415 0.284974037139684 3439 616434
SGTC_2026 5148700 152 µM -0.569385073454465 0.273313630699471 no 2416 0.284547422126751 3408 79838
SGTC_738 1315-0003 72.4 µM -0.569497360742892 0.273271361533175 no 2417 0.284509330652699 3494 6251474
SGTC_1670 st016595 4.04 µM -0.570325957978835 0.272959546459932 no 2418 0.284228319040913 3458 597879
SGTC_1146 3579-1023 7 µM -0.570367198653729 0.27294403151041 no 2419 0.284214336088804 3486 X1146
SGTC_469 w7 172 µM -0.57039071303579 0.27293518547724 no 2420 0.284206363513011 3470 45115570 A P450 inhibitor.
SGTC_1206 3978-0017 132 µM -0.571429625262039 0.272544492071076 no 2421 0.283854226009489 3546 3873677
SGTC_393 acivicin 6.25 µM -0.574954750182306 0.271220906268183 no 2422 0.282660950146456 3391 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2232 chlorophetanol 41.5365 µM -0.57675864050246 0.270544837568052 no 2423 0.282051256379323 3514 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_536 3852-0578 10.6 µM -0.577202040592665 0.270378787434479 no 2424 0.281901489371509 3527 2869208
SGTC_2367 9070478 135.38 µM -0.5779024659534 0.270116587025483 no 2425 0.28166498517329 3460 572802
SGTC_703 3875-0075 71.8 µM -0.57793962769389 0.270102679284898 no 2426 0.2816524398889 3487 2850814
SGTC_2611 pyromycin 23.93 µM -0.578725321398444 0.269808718155727 no 2427 0.281387263757569 3414 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.579203977635668 0.269629711238976 no 2428 0.28122577361567 3449 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1090 efavirenz 20.7 µM -0.579344493535786 0.269577172678834 no 2429 0.281178374536737 3485 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1144 3486-0183 12.5 µM -0.579466131365777 0.269531696726656 no 2430 0.281137346558443 3444 6744069
SGTC_1674 st016616 23.6 µM -0.579603214782634 0.269480450840514 no 2431 0.281091112308216 3426 625830
SGTC_2917 7979103 53.79 µM -0.579617590147646 0.269475077181529 no 2432 0.281086264128414 3502 2980565
SGTC_1865 st057639 52.2 µM -0.580718818485113 0.269063586442355 no 2433 0.280714988260036 3479 688818
SGTC_1603 st002045 67.8 µM -0.58078965635131 0.269037127593636 no 2434 0.280691113605525 3503 5887985
SGTC_2862 9027634 71.43 µM -0.580814276588902 0.26902793192593 no 2435 0.280682816018308 3431 5012562
SGTC_1516 st013856 110 µM -0.580865896819358 0.269008652263195 no 2436 0.280665419196718 3469 5281404 A mutagen and neurotoxin.
SGTC_2157 5649910 96.377 µM -0.581356969483633 0.268825276003845 no 2437 0.280499946150218 3444 2858091
SGTC_707 0865-0008 204 µM -0.582032485326076 0.268573127627508 no 2438 0.280272399861108 3473 723043
SGTC_1385 3091-4834 14.1 µM -0.583521306455745 0.268017818526959 no 2439 0.279771209070456 3468 4072814
SGTC_1863 st057641 20.1 µM -0.584432133934038 0.267678378067663 no 2440 0.279464806280848 3504 3921635
SGTC_1661 st013063 9.66 µM -0.585414871006253 0.267312382027273 no 2441 0.279134395953599 3501 721395
SGTC_2316 5844804 197.44 µM -0.586343810192873 0.266966653962493 no 2442 0.278822247958734 3494 776813
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.587528466841335 0.266526082116563 no 2443 0.278424418794888 3569 688664
SGTC_2202 7226349 200 µM -0.588710973538403 0.266086676852866 no 2444 0.278027587670871 3431 844334
SGTC_90 0870-0863 4.608 µM -0.589091994451296 0.26594517225522 no 2445 0.277899781701822 3476 1738164
SGTC_2729 fluphenazine 10.66 µM -0.59353946551776 0.264296282929567 no 2446 0.276410089653673 3433 3372 An atypical antipsychotic.
SGTC_3274 9138298 49.47 µM -0.593784859881482 0.264205455313612 no 2447 0.276328008318521 3484 17015756
SGTC_1172 0370-0043 85 µM -0.595096301340599 0.263720322199878 no 2448 0.275889550426343 3536 376585
SGTC_557 1315-0110 16.2 µM -0.595131183086604 0.263707424825466 no 2449 0.275877892982424 3499 6833801
SGTC_2442 5158906 48.48 µM -0.595380617337887 0.263615206968892 no 2450 0.275794539363196 3508 1893835
SGTC_225 nsc-122657 1.016 µM -0.595964967698631 0.263399232363386 no 2451 0.275599315062898 3473 275685
SGTC_2368 9071271 200 µM -0.597472326127954 0.262842533373487 no 2452 0.275096039002518 3469 27209959
SGTC_1476 4112-3294 3.34 µM -0.597553783829019 0.262812466486091 no 2453 0.275068854843317 3543 704369
SGTC_574 1315-0397 40 µM -0.597701534681301 0.262757934594003 no 2454 0.275019550632903 3556 6794277
SGTC_433 pimozide 108 µM -0.599133325371054 0.262229789176029 no 2455 0.27454199012398 3394 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2950 9072895 21.46 µM -0.599475010721468 0.262103831940478 no 2456 0.274428084641174 3494 17332245
SGTC_1910 st062352 60.4 µM -0.599552368549 0.262075319430207 no 2457 0.274402299590242 3472 2245730
SGTC_1297 1068-0111 14.1 µM -0.600000089561607 0.261910329870152 no 2458 0.274253087905943 3462 767057
SGTC_1990 st072050 59.8 µM -0.600625157400504 0.261680075396792 no 2459 0.274044839001656 3490 17233948
SGTC_1713 st033146 12.748 µM -0.600973055935766 0.261551966006651 no 2460 0.273928966257915 3545 674619
SGTC_3356 9151811 4.48 µM -0.601543410471229 0.261342009588082 no 2461 0.273739053673141 3461 1859254 YPR165W RHO1
SGTC_134 0269-0018 6.916 µM -0.601623669025887 0.261312472109358 no 2462 0.273712334979804 3449 4378915
SGTC_3082 9117008 49.47 µM -0.601623884766627 0.261312392712812 no 2463 0.273712263159782 3467 41448529
SGTC_1477 0139-0234 16 µM -0.603362451405147 0.260672971005523 no 2464 0.273133797803433 3518 620880
SGTC_1308 1187-1617 41.4 µM -0.603543939562125 0.260606268521526 no 2465 0.27307344701649 3523 2882570
SGTC_2721 ifenprodil 61.44 µM -0.605561450663151 0.259865363256584 no 2466 0.272403003618801 3543 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_89 0302-0250 142.109 µM -0.605994355068499 0.259706526344132 no 2467 0.272259250847399 3582 4203518 YLR208W SEC13
SGTC_1548 st061468 90.8 µM -0.606424244811563 0.259548845141969 no 2468 0.272116536456219 3494 390799
SGTC_1126 isoteolin 1.0172 µM -0.608980649850562 0.258612191883566 no 2469 0.271268632447843 3519 133323
SGTC_1965 Pectolinarigenin 58.4 µM -0.609477344123073 0.258430409005784 no 2470 0.271104042672861 3491 5320438 An anti-inflammatory.
SGTC_524 r073-0010 27.8 µM -0.609916270745384 0.258269823360226 no 2471 0.270958636849488 3480 2772106
SGTC_1962 st076595 64.5 µM -0.610272014944306 0.258139708782316 no 2472 0.270840815915638 3529 279619
SGTC_2822 7994718 71.43 µM -0.610426887102728 0.258083074416075 no 2473 0.270789530919718 3494 1018011
SGTC_1461 k072-0203 53.8 µM -0.610890822055725 0.257913459108896 no 2474 0.270635930631408 3478 5418714
SGTC_1137 ixabepilone 100 µM -0.611607990093936 0.257651375260053 no 2475 0.27039857520405 3558 154225 A novel microtubule stabilizer.
SGTC_1060 3448-7350 82 µM -0.612986638270933 0.257147946990298 no 2476 0.269942587368389 3515 570178
SGTC_831 k061-1017 217 µM -0.613582125293418 0.256930656756788 no 2477 0.269745749145643 3559 1240153
SGTC_2630 antimycin a 100 µM -0.613632581664967 0.25691224987065 no 2478 0.26972907409702 3505 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1959 st077091 55.8 µM -0.616442443355891 0.25588827406205 no 2479 0.268801274060043 3545 821356 YKL052C ASK1
SGTC_1545 lovastatin 49.4 µM -0.618043692082133 0.255305697730735 no 2480 0.268273268953008 3540 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2940 9060638 45.86 µM -0.618826901984801 0.255020998110408 no 2481 0.268015198898363 3523 4027022
SGTC_1262 0737-0114 49.6 µM -0.618951621107053 0.254975677595488 no 2482 0.267974115106123 3585 765919
SGTC_2832 7992762 51.95 µM -0.619297962818546 0.25484984582502 no 2483 0.267860043131802 3385 2985177
SGTC_2654 protoveratrine a 100 µM -0.620564079097113 0.25439012122993 no 2484 0.267443240153524 3523 5702278 A heart drug and vasodilator.
SGTC_1724 st037281 8.293 µM -0.621098338729333 0.254196262975724 no 2485 0.267267461124735 3566 574124 YDL195W SEC31
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.621559181696699 0.254029106506591 no 2486 0.267115884071569 3544 688761
SGTC_1514 1189-1591 158 µM -0.622488753116941 0.253692108917672 no 2487 0.266810268448624 3581 767698 YMR146C TIF34
SGTC_1180 1193-0155 285 µM -0.622596203535433 0.253653170053335 no 2488 0.266774953321037 3556 2921347
SGTC_55 0767-0285 6.563 µM -0.622664882087956 0.25362828333647 no 2489 0.266752382363156 3533 3116166
SGTC_2821 7996764 71.43 µM -0.623075701932624 0.253479443309516 no 2490 0.266617388064359 3645 2987135
SGTC_999 SEC7.066 22.7 µM -0.62360143529378 0.25328903708757 no 2491 0.266444683892689 3559 740511 YDR170C SEC7
SGTC_412 gemfibrozil 100 µM -0.623871642884552 0.253191204564131 no 2492 0.266355942330657 3544 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1299 1079-1439 3.74 µM -0.624836544992209 0.252842010204894 no 2493 0.266039171342118 3480 323161
SGTC_1443 4112-3303 14 µM -0.625007619856169 0.252780125339691 no 2494 0.265983028515274 3551 704433
SGTC_832 4083-0019 164 µM -0.625855610164668 0.252473489892641 no 2495 0.265704826283098 3635 1990758
SGTC_495 decylubiquinone 155 µM -0.62597147168365 0.252431609298839 no 2496 0.265666826773202 3528 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2571 chrysanthemic acid 100 µM -0.626373505203454 0.252286314188958 no 2497 0.265534991799949 3490 2743 An insecticide.
SGTC_2142 5622915 118.518 µM -0.62645951709604 0.252255235175822 no 2498 0.265506791060013 3536 5322196
SGTC_44 0929-0055 61.211 µM -0.627238406024684 0.251973888136318 no 2499 0.265251485757216 3481 1379590
SGTC_2458 5808907 16.39 µM -0.627428911012576 0.251905099924207 no 2500 0.265189060741763 3633 2731747
SGTC_2591 skatole 100 µM -0.627484616744853 0.251884987375219 no 2501 0.265170808397464 3566 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_449 xestospongin c 11.1929 µM -0.627686321947818 0.251812168823815 no 2502 0.265104723717772 3531 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_688 0527-0193 473 µM -0.628159309011911 0.251641457119007 no 2503 0.264949791770674 3538 4007154
SGTC_2922 7999257 32.47 µM -0.628200709444053 0.251626517678824 no 2504 0.264936232808772 3561 2988377
SGTC_317 4495-0002 170 µM -0.62825855410017 0.251605645087589 no 2505 0.264917288826817 3532 15991618
SGTC_2467 5474540 200 µM -0.628397058919185 0.251555670904127 no 2506 0.264871931638595 3554 5413519
SGTC_1462 k081-0014 26.5 µM -0.629944148887467 0.250997819097858 no 2507 0.264365563177823 3397 3270634
SGTC_3280 9140961 49.47 µM -0.630604870858842 0.250759774707056 no 2508 0.264149456619825 3523 4901226
SGTC_402 epigallocatechin gallate 10 µM -0.630838610228574 0.250675591905157 no 2509 0.264073027543917 3521 65064 An antioxidant.
SGTC_187 1488-2104 32.728 µM -0.631053199242199 0.250598319413184 no 2510 0.264002870253132 3586 2852859
SGTC_2666 tannic acid 100 µM -0.632716838115041 0.249999679274407 no 2511 0.263459286043872 3589 16134267 A thiamine antagonist.
SGTC_1145 3546-0597 10.2 µM -0.633798815637783 0.249610750503117 no 2512 0.263106063114591 3527 875334
SGTC_1113 artemisinin 1.17947 µM -0.634913790882917 0.24921029685209 no 2513 0.262742321066229 3576 2240 An anti-malaria and mitochondrial poison.
SGTC_837 0091-0265 12.5 µM -0.635318737811504 0.249064941046486 no 2514 0.262610277601572 3533 759367
SGTC_3222 9128301 49.47 µM -0.635403173691998 0.249034638449089 no 2515 0.262582749368638 3566 4911358
SGTC_24 0417-1663 219 µM -0.635602311155578 0.248963179179116 no 2516 0.262517831367276 3572 4329390
SGTC_1247 0448-0043 5.84 µM -0.636572907618448 0.248615042791795 no 2517 0.262201538521142 3584 3089013 YGL099W LSG1
SGTC_387 norethindrone acetate 66.7 µM -0.636610136601844 0.248601694556739 no 2518 0.262189410426103 3546 541197
SGTC_318 1488-0629 67.2 µM -0.637424787388341 0.248309701867174 no 2519 0.26192409341867 3579 3662576
SGTC_2178 5812956 200 µM -0.638776342627916 0.247825671812387 no 2520 0.261484220222958 3568 5403383
SGTC_1991 st073000 8.92 µM -0.640983216318415 0.247036412037471 no 2521 0.260766793758246 3645 4301969 YIL048W NEO1
SGTC_3135 9127742 49.47 µM -0.643543342329515 0.246122503712964 no 2522 0.259935800230995 3540 3643468
SGTC_1800 st050079 29.0735 µM -0.644232367743749 0.245876846954312 no 2523 0.25971238237176 3560 3645560
SGTC_1940 st075990 51.1 µM -0.644900101903493 0.245638906737805 no 2524 0.259495962846557 3687 1084979
SGTC_824 1304-0008 100 µM -0.645694518397197 0.24535598572911 no 2525 0.25923860564295 3595 768245
SGTC_3143 9086658 49.47 µM -0.646233221498502 0.245164233385654 no 2526 0.25906416380385 3619 25236626
SGTC_1937 st074714 47.2 µM -0.647990423676244 0.244539314650651 no 2527 0.258495572054883 3537 17250970
SGTC_2301 7769476 200 µM -0.64816678354991 0.244476642708929 no 2528 0.258438541614222 3569 977820
SGTC_3088 9117578 49.47 µM -0.648867028342714 0.244227886366299 no 2529 0.258212164027189 3648 678341
SGTC_947 3447-0010 211 µM -0.649438809371883 0.244024866991597 no 2530 0.258027392919219 3616 748350
SGTC_1738 st035555 74 µM -0.649579591376128 0.243974894213273 no 2531 0.257981909720883 3595 5331140
SGTC_1547 harmine 94.2 µM -0.650418512483574 0.243677220529042 no 2532 0.257710961228854 3641 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_997 3996-0078 137 µM -0.650613959301229 0.24360789847125 no 2533 0.25764785849532 3605 735687
SGTC_2811 7967822 32.47 µM -0.651303935886637 0.243363259298802 no 2534 0.257425154092899 3590 2232244
SGTC_1886 st057356 49.9 µM -0.652568849413373 0.242915114589133 no 2535 0.257017136644593 3556 24207747
SGTC_1898 st060199 18.6 µM -0.653512336985985 0.242581138437152 no 2536 0.256713019299513 3609 688866
SGTC_2911 7942208 15.64 µM -0.6537258693667 0.242505586670798 no 2537 0.256644216737213 3583 1243384
SGTC_1225 1216-0074 20.6 µM -0.653772934721572 0.242488935778712 no 2538 0.256629053036036 3584 4241466
SGTC_2079 5212404 121 µM -0.654978962348754 0.24206247580485 no 2539 0.256240649524942 3613 758462
SGTC_2037 5169046 200 µM -0.654985034242704 0.242060329769297 no 2540 0.256238694835491 3607 5718022
SGTC_2352 9027995 87.8 µM -0.655742130316738 0.241792824423527 no 2541 0.255995028234818 3551 2997347
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.657242649103964 0.241263119354721 no 2542 0.255512453176489 3675 688801
SGTC_1697 st025554 27.742 µM -0.658310148508141 0.240886660711224 no 2543 0.25516942906815 3590 1269519
SGTC_2962 9082311 13.18 µM -0.659456849248481 0.240482627598296 no 2544 0.254801223320091 3590 16459453
SGTC_615 k087-0205 167 µM -0.660144435060266 0.240240537972868 no 2545 0.254580572897512 3584 9642773
SGTC_203 k066-0004 30.888 µM -0.661439528869979 0.239784913901275 no 2546 0.254165241472019 3676 6795412
SGTC_2450 5739737 12.93 µM -0.662513603761452 0.239407403919547 no 2547 0.253821059689069 3621 2262825
SGTC_1394 3474-0001 65.7 µM -0.663173097240396 0.239175769686069 no 2548 0.2536098496916 3548 5017666 YIL048W NEO1
SGTC_548 1436-0017 110 µM -0.664583302150951 0.238680873889653 no 2549 0.253158526096544 3668 9677137
SGTC_3138 9097216 49.47 µM -0.664683185284348 0.238645842272198 no 2550 0.253126575411274 3632 25237486
SGTC_2951 9072950 58.06 µM -0.665112446206701 0.238495321317088 no 2551 0.252989287281486 3641 16488155
SGTC_3337 9144342 33.5465 µM -0.666109771164696 0.23814580864051 no 2552 0.252670469722948 3611 17682949
SGTC_2507 purpurin 79.67 µM -0.667187417643901 0.237768462978646 no 2553 0.252326213566185 3605 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2593 nobiletin 86.24 µM -0.667504874638487 0.237657365697889 no 2554 0.252224848513456 3579 72344 An anti-infammatory.
SGTC_2317 5986382 200 µM -0.668390378796807 0.237347625154072 no 2555 0.251942217675689 3664 877883
SGTC_2586 curcumin 80 µM -0.669348343735232 0.237012788323905 no 2556 0.251636647483763 3638 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_408 cantharidin 100 µM -0.669824066281603 0.236846605869931 no 2557 0.251484975010145 3597 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1802 st050112 57.9 µM -0.670815843181394 0.236500358098352 no 2558 0.251168926660858 3623 4662563
SGTC_1153 4055-0057 267 µM -0.672939366724238 0.235759934173187 no 2559 0.250492933038101 3630 882706
SGTC_1604 st002052 72.4 µM -0.675859083227462 0.234743986303207 no 2560 0.249565059065261 3669 6254834 YHR062C RPP1
SGTC_1438 4092-1045 4 µM -0.675949658560143 0.234712508362797 no 2561 0.2495363038251 3630 1351342
SGTC_2826 7992541 19.48 µM -0.676109265196928 0.234657045428583 no 2562 0.249485637280774 3691 2985066
SGTC_2394 5221648 200 µM -0.677671501770262 0.234114554677523 no 2563 0.248989999742287 3695 788586
SGTC_2297 7971671 152.32 µM -0.679594396497344 0.233447779022776 no 2564 0.248380659352531 3653 909016
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.679745051587893 0.233395582974769 no 2565 0.248332952308768 3581 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1233 0325-0408 14.2 µM -0.680005762965607 0.233305272062253 no 2566 0.248250405943107 3670 12874
SGTC_3326 9140064 16.379 µM -0.680006797928544 0.233304913587789 no 2567 0.248250078282581 3624 1868434
SGTC_1007 4101-0031 70 µM -0.680073915001628 0.233281667266133 no 2568 0.248228830076385 3620 1146276
SGTC_47 0149-0135 24.25 µM -0.680139074953358 0.233259100032688 no 2569 0.24820820239176 3601 5239155
SGTC_3321 9137793 26.8275 µM -0.681043914938412 0.232945846684361 no 2570 0.247921851723384 3633 4904192
SGTC_2264 7948757 110.76 µM -0.681504415050203 0.232786512456574 no 2571 0.247776187036294 3644 2971411
SGTC_880 0833-0487 87.2 µM -0.682658997868482 0.232387290207677 no 2572 0.247411172174001 3631 76075
SGTC_1947 st076332 61.6 µM -0.683040430187264 0.232255485381988 no 2573 0.247290647677299 3630 24208416
SGTC_599 1935-0052 86.5 µM -0.684801219936167 0.231647579918902 no 2574 0.246734682723841 3637 9557311
SGTC_60 0986-0278 202 µM -0.685296993748626 0.231476576158804 no 2575 0.246578264221674 3489 3110598
SGTC_675 1309-0189 238 µM -0.68556910683698 0.231382748037394 no 2576 0.246492434103047 3638 4246530
SGTC_314 1671-0008 2.74 µM -0.685697689158178 0.231338418565906 no 2577 0.246451882138809 3593 3913060
SGTC_2853 9015042 58.44 µM -0.687032283125307 0.230878589693454 no 2578 0.246031192500545 3605 6457456
SGTC_3223 9129970 49.47 µM -0.690457263567092 0.229700865451458 no 2579 0.244953338217689 3702 17248386
SGTC_3234 9132280 49.47 µM -0.69081215878093 0.229579022782503 no 2580 0.244841796810651 3670 17612295
SGTC_3131 9127911 49.47 µM -0.691724448509367 0.22926598159042 no 2581 0.244555195198867 3695 45595681
SGTC_2556 citropten 84.59 µM -0.69181338308614 0.229235477573346 no 2582 0.244527265506732 3677 2775 A potential DNA crosslinker.
SGTC_91 0417-1751 58.384 µM -0.692224221751536 0.229094591961753 no 2583 0.244398264907766 3745 6795624
SGTC_2760 etidronate 98.04 µM -0.693659308940634 0.228602850339819 no 2584 0.243947945033292 3662 3305 A chelator and antioxidant.
SGTC_470 aa-861 153 µM -0.693902705984099 0.228519507653466 no 2585 0.243871613246369 3649 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3198 9112019 49.47 µM -0.694032972881826 0.228474909386838 no 2586 0.24383076551882 3707 45595555
SGTC_1029 k015-0030 64.7 µM -0.694875130924165 0.228186705589404 no 2587 0.243566779555693 3712 2208316
SGTC_1611 st001856 99.4 µM -0.696341484551044 0.227685377343468 no 2588 0.243107499561187 3642 647478
SGTC_303 1348-1668 34.2 µM -0.696600076416118 0.227597032325915 no 2589 0.243026554011737 3696 5380509
SGTC_2344 7990960 76.95 µM -0.696645052105972 0.227581668855306 no 2590 0.243012477014177 3655 140813
SGTC_123 0083-0120 66.675 µM -0.697075792403139 0.227434559705769 no 2591 0.242877681409933 3628 16001701
SGTC_1111 tnp00062 510.699 nM -0.69715649258809 0.227407004427329 no 2592 0.242852431644252 3719 676306
SGTC_2733 amorolfine 100 µM -0.697468524920685 0.227300477908926 no 2593 0.242754815205426 3671 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2889 9059656 51.95 µM -0.698748161495165 0.226863909620224 no 2594 0.242354714934583 3738 3949838
SGTC_1993 st073995 70.8 µM -0.699470588939724 0.226617651095734 no 2595 0.242128993536129 3678 3098394
SGTC_2486 5283202 22.39 µM -0.699827210601837 0.226496142805245 no 2596 0.242017609655105 3676 1377751
SGTC_3347 9188721 44.724 µM -0.702051406886283 0.225739144343131 no 2597 0.241323552499745 3695 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_448 monastrol 171 µM -0.702638662969976 0.22553951260565 no 2598 0.241140480746801 3614 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_955 1216-0110 33 µM -0.702640866250616 0.225538763810976 no 2599 0.241139794036253 3625 3619719
SGTC_3085 9117376 49.47 µM -0.704515166894426 0.224902284348751 no 2600 0.240556004077167 3742 16480349
SGTC_533 1222-0222 6.71 µM -0.705356872942051 0.224616787434097 no 2601 0.240294087800743 3769 3982874
SGTC_2391 6285546 200 µM -0.705357115544264 0.224616705175892 no 2602 0.240294012331866 3671 846083
SGTC_1404 3909-7820 48.3 µM -0.70570251905669 0.224499607859799 no 2603 0.240186577049952 3649 23741373
SGTC_3204 9114183 49.47 µM -0.705772047788127 0.22447604069646 no 2604 0.240164953803098 3699 17027248
SGTC_1173 0443-0020 122 µM -0.706004697716139 0.224397192874478 no 2605 0.240092608022134 3693 5331295
SGTC_773 4358-1457 44.6 µM -0.706421236265926 0.224256062290092 no 2606 0.239963109159334 3683 1186886
SGTC_1770 st043884 66.3 µM -0.706775083423417 0.224136212251831 no 2607 0.239853130532453 3681 670149
SGTC_2154 5570129 200 µM -0.707264672795263 0.223970445559048 no 2608 0.239701007452318 3698 673366
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.707311611644988 0.223954556517387 no 2609 0.239686425583523 3714 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1318 1280-3875 124 µM -0.70755779112899 0.223871233987004 no 2610 0.239609956202181 3682 373245
SGTC_235 0330-0087 5 mM -0.707885516361585 0.223760338619591 no 2611 0.239508177380214 3716 46494818 YHR062C RPP1
SGTC_2319 6033012 152.6 µM -0.708449905259202 0.223569434430806 no 2612 0.239332955290127 3665 847246
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.708741626010264 0.223470796395829 no 2613 0.239242414135174 3664 15053
SGTC_200 k038-0079 37.545 µM -0.710450284883022 0.222893553778252 no 2614 0.238712474950929 3655 3436683
SGTC_2727 riluzole 51.77 µM -0.712093902461381 0.222339086744807 no 2615 0.238203314931303 3694 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_760 0568-0725 82.9 µM -0.712927441505286 0.222058197051662 no 2616 0.237945328686674 3722 3916171
SGTC_1685 st024049 53.0905 µM -0.713947498815582 0.221714729406413 no 2617 0.237629822268431 3696 1941139
SGTC_1348 1493-0373 93.8 µM -0.714806763357918 0.221425638630086 no 2618 0.23736422770482 3686 3010129
SGTC_1108 betulinic acid 729.144 nM -0.715143235010906 0.221312494926006 no 2619 0.237260270352151 3709 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_840 0245-0196 390 µM -0.715995899460237 0.221025921663101 no 2620 0.236996940445963 3761 3827528
SGTC_591 4299-0174 154 µM -0.716009333925867 0.221021408153635 no 2621 0.236992792741416 3683 5509088
SGTC_2864 9034755 47.6 µM -0.716019341646129 0.221018045944761 no 2622 0.236989703022806 3697 4930451
SGTC_1914 st062367 72.6 µM -0.71646371303066 0.220868783770019 no 2623 0.236852533004699 3708 978205
SGTC_553 k007-0256 45.7 µM -0.716952054113942 0.220704818969265 no 2624 0.23670184063535 3745 6287000
SGTC_2133 5320837 200 µM -0.717479466357845 0.220527814016398 no 2625 0.236539150931849 3670 2841355
SGTC_1062 mesoridazine 14.2 µM -0.717809588286101 0.220417063119303 no 2626 0.236437350260734 3697 4078 A neuroleptic.
SGTC_76 0433-0009 400.328 µM -0.71862892265655 0.220142326662514 no 2627 0.236184793941315 3759 2841569
SGTC_767 0929-0023 86 µM -0.720899929702877 0.219381847691968 no 2628 0.235485543059285 3778 1204563
SGTC_2592 piperlongumine 83.33 µM -0.721024488191895 0.219340181225945 no 2629 0.235447224145377 3713 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2673 kobusone 100 µM -0.721349340368754 0.219231535264788 no 2630 0.235347303490437 3751 6710676 An epoxy ketone and protein crosslinker.
SGTC_2643 anethole 100 µM -0.721619845583347 0.219141089112142 no 2631 0.23526411717702 3711 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_349 k015-0014 24 µM -0.72180150329807 0.219080362062259 no 2632 0.235208262540169 3707 2196908
SGTC_1053 3366-3204 134 µM -0.721992216501807 0.219016618232066 no 2633 0.235149631475122 3713 3632071 YPR165W RHO1
SGTC_966 1300-0360 30.2 µM -0.722616813661143 0.21880792806042 no 2634 0.234957667744795 3709 70588
SGTC_99 0109-0120 622.8 µM -0.723306644502655 0.21857757506066 no 2635 0.234745755756955 3749 759414
SGTC_2777 climbazole 1.536 µM -0.723879289153888 0.218386459771087 no 2636 0.234569922975349 3678 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_375 3970-0961 9.27 µM -0.724077742482621 0.218320250122708 no 2637 0.234509004105706 3693 2898222
SGTC_1124 fisetin 1.16336 µM -0.72429576548201 0.218247524810686 no 2638 0.234442088059128 3721 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2728 chlorpromazine 9.18 µM -0.725737723619087 0.21776688651793 no 2639 0.233999785543691 3730 2726 A thorazine and dopamine antagonist.
SGTC_77 0828-0286 12.516 µM -0.726582815660001 0.217485481648524 no 2640 0.233740779180498 3683 745345
SGTC_640 3381-0960 37.1 µM -0.72722555055674 0.217271599733048 no 2641 0.233543898283732 3750 1745025
SGTC_2675 theaflavin digallate 100 µM -0.727265233275769 0.217258398557781 no 2642 0.233531745790649 3690 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2028 5153890 36.43 µM -0.727869670430783 0.217057378865268 no 2643 0.233346685445136 3694 2830968 YPR165W RHO1
SGTC_618 k072-0232 33.2 µM -0.728157214802025 0.216961787007726 no 2644 0.233258676640518 3719 5872756 YGL099W LSG1
SGTC_693 4161-2696 114 µM -0.728313363107384 0.216909886931621 no 2645 0.233210891994289 3747 805759
SGTC_1981 st071826 47 µM -0.731227890810394 0.215942483409942 no 2646 0.232319983448453 3706 11838600
SGTC_3294 9122953 26.2835 µM -0.732243480035838 0.215605972547584 no 2647 0.232009985050092 3733 16459826
SGTC_626 0214-0009 33 µM -0.732743021627275 0.215440563348658 no 2648 0.231857589546095 3765 3437874
SGTC_1512 0259-0544 12.2 µM -0.73309108799307 0.21532535445377 no 2649 0.231751437663021 3701 18476
SGTC_2691 st077356 60.2 µM -0.733207862469 0.215286710472086 no 2650 0.231715830319027 3784 2839272
SGTC_3167 9103034 49.47 µM -0.733583525579306 0.215162420210916 no 2651 0.231601302288561 3737 5127859
SGTC_482 fipronil 114 µM -0.733666966095426 0.215134819099426 no 2652 0.231575868146115 3764 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_689 0833-0039 98 µM -0.733805084064346 0.215089135866562 no 2653 0.231533770772412 3715 5374726
SGTC_2665 lovastatin 100 µM -0.734469284262863 0.214869526893618 no 2654 0.231331386877519 3747 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_364 0083-0097 67.7 µM -0.735250765693984 0.214611307290642 no 2655 0.231093393412366 3785 5207356
SGTC_2468 5987765 72.9 µM -0.736191952700182 0.214300556812515 no 2656 0.230806944460483 3778 26772094
SGTC_920 mycophenolic acid 780.421 nM -0.738483976144214 0.213544898133446 no 2657 0.230110200473357 3764 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3000 9075062 71.4286 µM -0.73868129857787 0.213479915444692 no 2658 0.230050272198997 3713 17057871
SGTC_1100 amiodarone 5.07 µM -0.739253835725149 0.213291431407523 no 2659 0.229876437898875 3810 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.739727954662831 0.213135420942916 no 2660 0.229732541112094 3773 1377
SGTC_1575 cyproterone acetate 48 µM -0.740107091597502 0.213010712540848 no 2661 0.229617508009154 3726 9880 An androgen receptor antagonist and liver toxin.
SGTC_698 k064-0052 127 µM -0.741530288297961 0.212542964636639 no 2662 0.229185987050492 3798 5088751
SGTC_3140 9094243 49.47 µM -0.742171973868606 0.212332264607136 no 2663 0.228991573357431 3759 19291112
SGTC_1658 st012944 20 µM -0.742373931299654 0.212265976337643 no 2664 0.228930404766618 3675 24207260
SGTC_789 1309-1135 70.6 µM -0.743018547763389 0.212054475506889 no 2665 0.228735225565434 3745 3092424
SGTC_3115 9123671 49.47 µM -0.743860388903855 0.211778450238773 no 2666 0.228480470728423 3823 3286988
SGTC_2457 5731572 11.68 µM -0.745251438839766 0.211322809846026 no 2667 0.228059865889928 3779 2865357
SGTC_3141 9094609 49.47 µM -0.747434778454126 0.210608813024629 no 2668 0.227400579331902 3717 25236309 YDL196W YDL196W
SGTC_1102 cgs 12066b 26.1 µM -0.747439766820459 0.210607183348966 no 2669 0.227399074262973 3755 6438352 A 5-HT1B full agonist.
SGTC_2947 9072639 7.68 µM -0.747976325638135 0.210431935329332 no 2670 0.227237218758653 3757 16488146
SGTC_1123 mangostin 811.285 nM -0.749732390243603 0.20985897760039 no 2671 0.22670794777854 3772 5281650 An antioxidant.
SGTC_713 1488-1073 324 µM -0.751283181811753 0.209353758364978 no 2672 0.226241124287238 3728 3312542
SGTC_1848 st056003 16.4 µM -0.751533353868597 0.209272324031379 no 2673 0.226165867719277 3798 146492
SGTC_712 r015-0009 80.6 µM -0.753303665226186 0.208696597130861 no 2674 0.225633728406212 3771 6813872 YLR060W FRS1
SGTC_1887 st057648 70.8 µM -0.754134384034587 0.208426759340724 no 2675 0.225384266398337 3791 688672
SGTC_1196 1588-0294 184 µM -0.754250630468716 0.208389016073481 no 2676 0.225349370452149 3767 6144269
SGTC_723 4182-0001 115 µM -0.754549250389354 0.208292077675266 no 2677 0.225259741945274 3744 744821 YLR208W SEC13
SGTC_3355 9151058 44.0485 µM -0.754597879528147 0.208276294138386 no 2678 0.22524514818952 3778 17015728
SGTC_296 1222-0039 74.9 µM -0.756860575545632 0.207542672487909 no 2679 0.224566698483003 3730 5984176
SGTC_3295 9122362 53.5725 µM -0.757147781508807 0.207449662602713 no 2680 0.224480665271474 3792 4730473
SGTC_3349 9149703 23.001 µM -0.759363062111512 0.206733085936524 no 2681 0.223817701666034 3743 4910494
SGTC_1279 0874-0590 65.2 µM -0.761988004153351 0.205885896019442 no 2682 0.223033581871405 3813 3523074
SGTC_2273 7815444 169.05 µM -0.762728701092615 0.205647212038086 no 2683 0.222812605035502 3714 2824616
SGTC_3328 9140624 29.0385 µM -0.762735773590839 0.205644933770985 no 2684 0.222810495653516 3773 4904392
SGTC_322 k048-0136 19.3 µM -0.768348290755829 0.203841698261151 no 2685 0.221140146074312 3830 6823282
SGTC_1082 camptothecin 424.86 nM -0.768416870692472 0.20381972278032 no 2686 0.221119780303408 3727 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3221 9128209 49.47 µM -0.768705545642225 0.20372723641648 no 2687 0.221034066008467 3826 16460723
SGTC_2612 dictamnine 15.46 µM -0.769413147654685 0.203500639064373 no 2688 0.220824042992347 3771 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1844 rapamycin 4 nM -0.769849831384647 0.20336087367163 no 2689 0.220694488141291 3731 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_948 3448-0295 75.3 µM -0.770677519991568 0.203096120117947 no 2690 0.22044904988955 3789 678569
SGTC_2354 9060492 162 µM -0.77076859312451 0.203067001039811 no 2691 0.220422053117797 3855 6471895
SGTC_1347 1493-0251 600 nM -0.771901052432085 0.202705124784472 no 2692 0.220086516979302 3823 3986378
SGTC_3121 9125696 49.47 µM -0.773498126044865 0.20219543695026 no 2693 0.219613818680954 3846 1235365
SGTC_1192 1488-0095 21.4 µM -0.77453227697684 0.201865808830423 no 2694 0.219308044243911 3824 915875
SGTC_2274 7947094 46.08 µM -0.776288118776167 0.201306884389483 no 2695 0.218789443344854 3769 2971028
SGTC_2247 cerulenin 830 nM -0.777040325545722 0.201067723963329 no 2696 0.218567489590574 3820 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1627 st003713 25.6 µM -0.778534467477327 0.200593174668467 no 2697 0.218126997638506 3860 16195070 YER133W GLC7
SGTC_396 dithiazanine 1.25 µM -0.778983184176437 0.200450790709117 no 2698 0.217994810248381 3791 10578 An antihelmenthic.
SGTC_1687 st020778 55.3625 µM -0.780518845672736 0.19996396382794 no 2699 0.217542769595836 3807 4259299
SGTC_1563 conessine 56.1 µM -0.781828286368409 0.199549414284931 no 2700 0.217157747492469 3865 441082 An anti-amoebic, histamine inhibitor.
SGTC_782 0083-0095 30.5 µM -0.781909944307273 0.199523579734952 no 2701 0.217133750203723 3792 3591729 An indicator and reagent.
SGTC_1277 0873-0036 22 µM -0.782956926730658 0.199192518825577 no 2702 0.216826203231215 3853 5965735
SGTC_2409 alverine citrate 63.97 µM -0.785539110659392 0.198377435284384 no 2703 0.216068774320083 3993 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2680 butyl paraben 22.24 µM -0.785635905462142 0.19834692054819 no 2704 0.216040411449883 3850 7184 An antifungal and steroid mimetic.
SGTC_1368 1852-0141 284 µM -0.785914045226687 0.198259252251064 no 2705 0.215958922775404 3798 2838987
SGTC_616 4092-0450 108 µM -0.78607895197513 0.198207285494296 no 2706 0.215910617229715 3854 787165
SGTC_2250 alverine citrate 130 µM -0.788733552832266 0.197371878092858 no 2707 0.215133876480857 3730 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2170 morpholine 200 µM -0.790200979071498 0.196910991897857 no 2708 0.214705202174243 3843 121171 Reacts with secondary amines.
SGTC_1546 5-methoxyflavanone 78.7 µM -0.790201551124764 0.196910812355695 no 2709 0.214705035159088 3817 147795
SGTC_2448 5185112 27.17 µM -0.79059507392122 0.196787326479784 no 2710 0.214590161177312 3823 5718189
SGTC_1669 st015249 58.4 µM -0.79138769011456 0.196538749089544 no 2711 0.214358895565423 3886 722793
SGTC_121 0557-0495 61.343 µM -0.793332798637824 0.195929538113591 no 2712 0.213791976200423 3955 3104427
SGTC_2259 7964009 200 µM -0.793916473064695 0.195746954108562 no 2713 0.213622029515567 3853 313134
SGTC_2502 avocadyne acetate 18.59 µM -0.794501612654903 0.195564015476327 no 2714 0.213451735253476 3793 3952079
SGTC_1906 st060206 94.7 µM -0.795342410283038 0.195301329492401 no 2715 0.213207174941708 3814 5133468
SGTC_2245 6637752 200 µM -0.796497062242879 0.194940937198267 no 2716 0.212871591183473 3883 681890
SGTC_2809 7964133 12.99 µM -0.797028951865378 0.194775058870839 no 2717 0.212717108530878 3851 1253665
SGTC_2305 7443522 69.23 µM -0.797068438977446 0.194762747604866 no 2718 0.212705642457922 3765 5415886
SGTC_484 loperamide 105 µM -0.798699050061207 0.194254770203723 no 2719 0.212232468870685 3801 3955 An opioid-receptor agonist.
SGTC_3227 9130768 49.47 µM -0.799940341735426 0.193868617243882 no 2720 0.21187268149111 3857 17720899
SGTC_1753 st043925 64 µM -0.803218095099728 0.192851193305643 no 2721 0.210924344227908 3887 670181
SGTC_1829 berberine 14.4 µM -0.807717352789346 0.19145993393895 no 2722 0.209626655904642 3872 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2293 7624732 200 µM -0.809945991861672 0.190773078093891 no 2723 0.208985608470218 3762 894453
SGTC_1873 rapamycin 2 nM -0.810414475726355 0.190628886184828 no 2724 0.208851000434152 3823 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3099 9120367 49.47 µM -0.811258949321828 0.190369139629505 no 2725 0.20860848949028 3872 24824940
SGTC_954 1189-0853 2.85 µM -0.812795133851657 0.189897191568835 no 2726 0.208167762982956 3815 2828194
SGTC_1867 st057372 64 µM -0.813660310555558 0.189631708095499 no 2727 0.207919788571758 3835 688837
SGTC_3174 9107204 49.47 µM -0.815681588521372 0.189012359990612 no 2728 0.207341135982909 3889 3938802
SGTC_2603 homopterocarpin 100 µM -0.818254832659886 0.188225686907896 no 2729 0.206605845571282 3901 101795 A weak amylase inhibitor.
SGTC_1131 3454-3128 32.3 µM -0.82209795824897 0.187054563295595 no 2730 0.205510573722103 3939 710982
SGTC_982 1491-0518 27.5 µM -0.822589821123474 0.186905002940373 no 2731 0.205370644506157 3821 3091256
SGTC_3014 9081533 49.47 µM -0.822865666078386 0.186821159377852 no 2732 0.205292194626432 3901 21367265
SGTC_2402 5553605 200 µM -0.823121812983005 0.186743323919768 no 2733 0.205219362784823 3912 6758546
SGTC_3038 9091290 49.47 µM -0.823364837044384 0.18666949466523 no 2734 0.205150276437247 3851 25236843
SGTC_2388 9080168 200 µM -0.825310093409332 0.18607918884205 no 2735 0.204597781459932 3840 15943073
SGTC_3249 9135183 49.47 µM -0.826712873912482 0.1856542212143 no 2736 0.204199911358054 3877 4902779
SGTC_3258 9138477 49.47 µM -0.82809373577649 0.18523648240499 no 2737 0.20380870841955 3910 4970355
SGTC_2165 5727197 32.143 µM -0.828510097519555 0.185110639130546 no 2738 0.203690839413567 4012 1361712
SGTC_771 0250-0039 27.3 µM -0.829310488499883 0.184868874132809 no 2739 0.203464368695795 3848 3005115
SGTC_1253 0550-0034 176 µM -0.829560673707431 0.184793343808768 no 2740 0.20339360958886 3896 5969915
SGTC_633 0437-0093 97.7 µM -0.829965978811214 0.184671023868571 no 2741 0.2032790095662 3829 2831118
SGTC_2464 5717415 7.67 µM -0.830027679567745 0.18465240716993 no 2742 0.203261567056886 3865 5285744
SGTC_1684 st024538 14.6195 µM -0.830092238063186 0.184632929467552 no 2743 0.203243317634709 3858 6732859
SGTC_645 0845-0943 5.41 µM -0.832317061258903 0.183962467181772 no 2744 0.202615001432106 3879 1885106
SGTC_1391 3442-0225 151 µM -0.832425961922865 0.183929688354963 no 2745 0.202584276439128 3824 5227075
SGTC_345 1362-0200 395 µM -0.832861637357852 0.183798587527057 no 2746 0.202461383794445 3878 1419823
SGTC_1380 2291-0730 164 µM -0.833291471278372 0.183669301550246 no 2747 0.202340182579911 3924 2999191
SGTC_2049 5262831 67.185 µM -0.835246334461305 0.183082030525016 no 2748 0.20178951319369 3932 763417
SGTC_1852 st056254 31.4 µM -0.835636045192418 0.182965095612467 no 2749 0.201679842166504 3822 442583
SGTC_1864 st057645 30.4 µM -0.836121173009799 0.182819595396943 no 2750 0.201543369092316 3914 688666
SGTC_2380 9035439 200 µM -0.837833306335908 0.182306667438516 no 2751 0.201062165037072 4005 6462575
SGTC_174 3553-0389 74.3 µM -0.838818513971444 0.182011922890821 no 2752 0.200785579893915 3912 738071
SGTC_1961 st076550 68.7 µM -0.838977364430163 0.181964427511281 no 2753 0.200741005933615 3923 1579337
SGTC_15 0266-0086 27.098 µM -0.840117301111869 0.181623820359999 no 2754 0.200421310239865 3960 1712902 YIL048W NEO1
SGTC_1901 st060216 58.6 µM -0.840221411749557 0.181592732538448 no 2755 0.200392127619166 3878 688792
SGTC_3187 9109394 49.47 µM -0.841348884861921 0.18125627823337 no 2756 0.200076256006363 3892 17098090
SGTC_1474 0330-0125 5.35 µM -0.841793671888292 0.181123654797704 no 2757 0.19995172734125 3889 X1474
SGTC_2849 9019321 12.99 µM -0.842917541011142 0.180788818427574 no 2758 0.199637281280784 3909 16489627
SGTC_2043 5101342 149 µM -0.843757994530223 0.180538674347465 no 2759 0.199402326326274 3906 678451
SGTC_2216 7189485 200 µM -0.846947012325026 0.179591503249537 no 2760 0.198512328370898 3907 731273
SGTC_463 ikarugamyin 104 µM -0.848408852941852 0.179158367346962 no 2761 0.198105157014411 3943 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_297 0986-0032 24 µM -0.848923096489246 0.179006155976661 no 2762 0.197962043020023 3857 2847425
SGTC_2806 7952793 58.44 µM -0.850065039118423 0.178668442513053 no 2763 0.197644463730525 3960 2972490
SGTC_2359 9039622 200 µM -0.85263143478835 0.177910932208334 no 2764 0.19693186233506 3850 6463596
SGTC_36 0335-0881 14.2 µM -0.852685873312774 0.177894885827637 no 2765 0.196916763461394 3822 23828853
SGTC_2699 st077704 54.6 µM -0.854881489223255 0.177248463728838 no 2766 0.19630837961545 3916 645852
SGTC_2356 9061756 188.97 µM -0.855088908589322 0.177187473154075 no 2767 0.196250964690388 3941 20104043
SGTC_1331 1472-0049 76.2 µM -0.855987352627 0.176923443489792 no 2768 0.196002387572379 3862 24051409
SGTC_1181 1222-0449 220 µM -0.856876064427697 0.176662518624025 no 2769 0.195756691124665 3930 658318
SGTC_1185 1319-0113 81.3 µM -0.857575073414219 0.176457461351698 no 2770 0.195563572000569 3979 4672763
SGTC_715 0868-0130 184 µM -0.85965597744374 0.17584791097033 no 2771 0.194989354171789 3936 2876258
SGTC_3301 9125354 19.7965 µM -0.860074149336572 0.175725578773021 no 2772 0.194874084993255 3886 41905162
SGTC_3146 9095609 49.47 µM -0.860183915937071 0.175693476537076 no 2773 0.194843834672491 3972 17173999
SGTC_2470 5664817 21.68 µM -0.860226771731106 0.175680943980765 no 2774 0.194832024919643 3933 2859561
SGTC_499 genistein 192 µM -0.861365641206112 0.175348105639654 no 2775 0.194518346675925 3927 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1624 st003710 6.25 µM -0.862282376724913 0.175080477312405 no 2776 0.194266074099062 3942 24207033
SGTC_821 1114-0266 29.2 µM -0.862490556314555 0.175019738266484 no 2777 0.194208813808366 3951 3123235
SGTC_3351 9150312 21.596 µM -0.863050590820648 0.174856407435638 no 2778 0.194054826015525 3863 4904905
SGTC_2112 5488546 200 µM -0.863974604769259 0.174587135654198 no 2779 0.193800920649752 3884 600757
SGTC_3078 9116413 49.47 µM -0.865626348036073 0.174106448890205 no 2780 0.193347550889356 3841 17177322
SGTC_3193 9111931 49.47 µM -0.867764763969895 0.173485382558169 no 2781 0.1927615616409 3949 17087244
SGTC_2850 9015429 58.44 µM -0.868730177501725 0.173205457271539 no 2782 0.19249736566467 3992 6457570
SGTC_962 1254-0300 21.5 µM -0.869201477353664 0.173068906649372 no 2783 0.192368469754636 3903 7340576
SGTC_2925 9010536 32.5 µM -0.869516404209178 0.172977700510928 no 2784 0.192282369756569 3893 2994177
SGTC_826 1683-5028 118 µM -0.869786958638984 0.172899369554678 no 2785 0.192208419863746 3986 722377
SGTC_2023 5144124 124 µM -0.870070217120357 0.172817384743745 no 2786 0.19213101625265 3923 2830192
SGTC_2425 5628681 7.85 µM -0.87222503623696 0.172194516847802 no 2787 0.191542811921894 3995 5714958
SGTC_3352 9151559 45.5865 µM -0.872485464670651 0.172119335054958 no 2788 0.191471797163414 3926 17159339
SGTC_2773 thioridazine 9.09 µM -0.872838375240922 0.172017488489269 no 2789 0.191375589719416 3951 5452 An antipsychotic.
SGTC_395 anisomycin 6.25 µM -0.873364112480446 0.171865837184819 no 2790 0.191232322705929 3948 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3184 9108758 49.47 µM -0.876089260265457 0.171081124651374 no 2791 0.190490755387073 3951 902885
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.876509919273574 0.170960199415666 no 2792 0.190376443161201 3979 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_819 1013-0258 27.7 µM -0.87788913389944 0.170564105530484 no 2793 0.190001943294036 3967 5753198
SGTC_2552 juarezic acid 87.02 µM -0.878582870261566 0.170365095056694 no 2794 0.189813743481473 3945 1549512
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.878938893022799 0.170263021440873 no 2795 0.189717204605514 3941 6857784
SGTC_6 0844-0013 19.835 µM -0.883117197260605 0.169068008666315 no 2796 0.188586476716035 4073 1584900
SGTC_1218 1348-1416 30.7 µM -0.884261294378049 0.168741733690937 no 2797 0.188277588585432 3893 6787668
SGTC_3275 9138069 49.47 µM -0.884649365985232 0.168631154934467 no 2798 0.188172886322924 4043 17617007
SGTC_1412 3909-8563 178 µM -0.885082040171709 0.168507921860607 no 2799 0.188056192594428 4021 23767530
SGTC_1396 3511-0007 98.6 µM -0.885856121019257 0.168287594776446 no 2800 0.187847531779745 3961 X1396
SGTC_343 4130-2827 29.8 µM -0.888096234454848 0.167651034558529 no 2801 0.187244494006645 3992 1118244
SGTC_2683 piperine 63.03 µM -0.88898860064563 0.167397888458366 no 2802 0.187004603110152 3928 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2655 perillic acid 100 µM -0.889465965012743 0.167262571093231 no 2803 0.18687635343435 3987 5702197 An apoptosis inducer.
SGTC_2261 9010538 184.68 µM -0.889543466271625 0.167240608646283 no 2804 0.186855536926324 3957 6457250
SGTC_3171 9103192 49.47 µM -0.889898623441563 0.16713998734358 no 2805 0.186760161580018 3978 13018434
SGTC_666 0272-0154 136 µM -0.890749626398328 0.166899044407178 no 2806 0.186531752429656 3963 6870312
SGTC_1387 3342-1166 1.8 µM -0.894211271616097 0.165921265564909 no 2807 0.185604431284223 3951 3418228
SGTC_1999 st074831 12.5 µM -0.894478573742049 0.165845917495926 no 2808 0.185532944355181 3925 17112523
SGTC_2996 9066192 71.4286 µM -0.895132368601621 0.165661716711515 no 2809 0.185358166340793 4026 6472854
SGTC_3097 9117246 49.47 µM -0.89582728536299 0.165466075296642 no 2810 0.185172507375075 3973 16423892
SGTC_1779 st039427 55 µM -0.896189915200621 0.165364042707189 no 2811 0.185075670453502 3921 1124498
SGTC_2446 5162541 200 µM -0.896475450591151 0.165283730714511 no 2812 0.184999443028344 3924 1549321
SGTC_340 k038-0059 454 µM -0.896979251601324 0.165142089136843 no 2813 0.184864994308311 3952 23733424
SGTC_2674 ligustilide 100 µM -0.898017816262926 0.164850348973527 no 2814 0.18458802559412 4024 5319022 A signalling regulator.
SGTC_120 rhodamine 6G 52.259 µM -0.898030601801745 0.164846759506467 no 2815 0.184584617502545 3996 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1384 3089-0840 101 µM -0.89810952641859 0.164824602991425 no 2816 0.184563580356667 3946 1069836
SGTC_177 1327-0068 8.361 µM -0.900078924205468 0.164272358395534 no 2817 0.184039125525682 3959 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1664 st014217 9.02 µM -0.900404399092816 0.164181206690488 no 2818 0.183952540295493 3998 3982782
SGTC_890 0929-0006 47.2 µM -0.900657364222363 0.164110384551142 no 2819 0.183885262168033 3941 1378169
SGTC_2818 7996756 12.99 µM -0.903892556902286 0.163206381793361 no 2820 0.183026188138199 3977 2241621
SGTC_2438 5259590 200 µM -0.904132918206603 0.163139347544772 no 2821 0.182962462613917 3994 1201127
SGTC_472 calcifediol 10 µM -0.90450014671942 0.163036965919714 no 2822 0.182865128301236 4004 5283731 A vitamin D metabolite.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.904512043808778 0.163033649764376 no 2823 0.18286197550546 3931 16623 A steroid.
SGTC_2279 7948423 32.93 µM -0.90530395361064 0.16281301403784 no 2824 0.182652191235291 3904 1247112
SGTC_3255 9139072 49.47 µM -0.905588446681314 0.162733798231271 no 2825 0.182576863081548 3969 17646060
SGTC_3247 9135149 49.47 µM -0.906559968771179 0.162463471315593 no 2826 0.182319769478891 3956 8934436 YOR116C RPO31
SGTC_2371 9071574 200 µM -0.906641577244182 0.162440776995335 no 2827 0.182298183756876 3982 45596039
SGTC_2731 amoxapine 43.43 µM -0.907127849791505 0.162305593309813 no 2828 0.182169596105084 4059 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1248 0469-0687 58.6 µM -0.908378013256661 0.16195838434542 no 2829 0.181839269011292 3984 4017482
SGTC_422 cantharidin 155 µM -0.910030927970383 0.161500062265459 no 2830 0.181403099670604 3922 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_62 0180-0423 3.232 µM -0.910540857356292 0.161358839316099 no 2831 0.181268672372431 3928 30102 YGL099W LSG1
SGTC_582 0987-0078 156 µM -0.910686924372002 0.161318401471279 no 2832 0.181230177764966 4012 1625765
SGTC_128 0906-2981 13.371 µM -0.914253949495589 0.160332942194408 no 2833 0.180291710985818 3919 6740226
SGTC_1520 flindersine 88 µM -0.916009892222688 0.15984927732637 no 2834 0.179830853253933 4122 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_515 4092-1064 102 µM -0.916644892882891 0.159674605075087 no 2835 0.179664375855092 4018 717353
SGTC_144 4161-2749 112.381 µM -0.918275771727598 0.159226565040965 no 2836 0.179237254133188 3916 797501 YMR168C CEP3
SGTC_2732 terfenadine 20 µM -0.918577545951591 0.159143751063087 no 2837 0.179158290544978 3995 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1839 st053978 48 µM -0.920146347895627 0.15871368940763 no 2838 0.178748143488279 3992 3788398
SGTC_541 4513-1321 94 µM -0.921409185069613 0.158368057075596 no 2839 0.178418417555372 3988 747515
SGTC_3008 9078912 71.4286 µM -0.922195428445 0.1581531157387 no 2840 0.178213323619295 3984 16648731
SGTC_146 3448-8650 53.125 µM -0.923596916174537 0.157770455412181 no 2841 0.177848110015766 3977 2891488 YIL048W NEO1
SGTC_447 ml7 120 µM -0.923598975960008 0.15776989345904 no 2842 0.177847573604046 4019 4216 Selective myosin light chain kinase inhibitor.
SGTC_1502 4534-4282 27.7 µM -0.923781558116329 0.157720086399502 no 2843 0.177800029401643 3956 3278949
SGTC_527 4476-4215 268 µM -0.927859494988349 0.15661034723017 no 2844 0.176740228845311 3980 4418754
SGTC_215 1287-0124 461.5 µM -0.928666358758218 0.156391383999392 no 2845 0.176531010111951 4014 5560863
SGTC_191 3914-0123 66.505 µM -0.929357936601442 0.156203867113536 no 2846 0.176351809593243 3959 3144412
SGTC_1665 st014639 11.4 µM -0.930142876415963 0.155991215277982 no 2847 0.176148556777982 4051 981133 YIL048W NEO1
SGTC_1 0258-0098 57.368 µM -0.930478887622243 0.155900243209557 no 2848 0.176061595163452 3946 6790032 YDR047W HEM12
SGTC_929 2805-0021 398 µM -0.932817442058118 0.155268069157234 no 2849 0.175457117003557 4081 3098024
SGTC_1559 coumarin 343 70.1 µM -0.935049186559192 0.154666348691802 no 2850 0.174881475792816 4048 108770 A hepatotoxic, DNA x-linker.
SGTC_1076 itraconazole 331 nM -0.936721252370891 0.154216539232402 no 2851 0.174450980652963 4014 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2587 piperic acid 92.2 µM -0.939049074302263 0.153591764166917 no 2852 0.173852774479756 4025 5370536
SGTC_2912 7964298 10.93 µM -0.939624589726428 0.153437557654966 no 2853 0.173705079285426 4048 2975850
SGTC_1023 4482-3888 16 µM -0.940844703737868 0.153110973420275 no 2854 0.173392224089863 4053 3303168
SGTC_1632 st005650 90 µM -0.942542417736898 0.15265731851908 no 2855 0.172957502418355 4055 2759605
SGTC_510 ag-490 170 µM -0.944233551654179 0.152206309297462 no 2856 0.172525156697154 4140 5328779
SGTC_2162 5663267 200 µM -0.945420884940547 0.151890188026503 no 2857 0.172222021967228 3997 6456493
SGTC_1629 st005085 44.9 µM -0.946234318520047 0.151673867552793 no 2858 0.172014542825402 3990 24207091
SGTC_268 camptothecin 39.6153 µM -0.947655562684907 0.151296400615783 no 2859 0.171652415080063 3988 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1389 3405-0187 19 µM -0.947771134220221 0.151265733570831 no 2860 0.17162298930883 4001 799890
SGTC_2635 hydroquinidine 100 µM -0.95078971730063 0.150466213251855 no 2861 0.17085556673951 3956 442912 An experimental heart treatment.
SGTC_3211 9128781 49.47 µM -0.951315790919462 0.150327162781903 no 2862 0.170722046648918 4065 17194361
SGTC_2897 9048598 12.99 µM -0.954188502997176 0.149569365498084 no 2863 0.169994116608202 4015 6467404
SGTC_814 3342-0569 96 µM -0.954490169602196 0.149489936548263 no 2864 0.169917791486531 4079 4346283
SGTC_2767 sibutramine 71.45 µM -0.957976591404593 0.148574003170508 no 2865 0.169037281295363 4040 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2942 9052777 62.25 µM -0.958365162237981 0.148472152892761 no 2866 0.168939327956602 4090 6469503
SGTC_2417 cerulenin 830 nM -0.960694365152641 0.147862612602526 no 2867 0.168352932644319 4077 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_879 0831-1030 162 µM -0.960876576969382 0.147814999477444 no 2868 0.168307114648096 4070 1549252
SGTC_417 st075190 100 µM -0.96246579379435 0.147400162102133 no 2869 0.167907838876338 4045 222757
SGTC_1623 st003709 20.3 µM -0.962757396252019 0.147324129147858 no 2870 0.16783464276078 4013 16192618
SGTC_2459 5811157 9.22 µM -0.962794931347147 0.147314344088796 no 2871 0.167825222442634 4016 2870684 YBR192W RIM2
SGTC_455 paf C-16 10 µM -0.96349733977283 0.147131312921518 no 2872 0.16764899926193 4013 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1926 methyl fluorone black 53.6 µM -0.963533061538137 0.147122008742772 no 2873 0.167640040420882 3784 72721 Reacts with homocysteine.
SGTC_3013 9080133 71.4286 µM -0.963592785013169 0.147106453900859 no 2874 0.167625062759154 4140 17050193
SGTC_2521 angolensin 13.4 µM -0.965570904520641 0.146591880266572 no 2875 0.167129470110452 4113 821428 A flavenoid.
SGTC_371 0195-0006 7.36 µM -0.966036494447395 0.146470940923877 no 2876 0.167012959967355 3887 3928593
SGTC_71 0417-1750 47.813 µM -0.966323552037294 0.146396409647124 no 2877 0.166941152217623 4072 6811472
SGTC_1452 4194-0072 190 µM -0.968555715087452 0.145817722472979 no 2878 0.166383453935456 4123 1343545
SGTC_1731 st035964 63 µM -0.970252512756323 0.145378858421631 no 2879 0.16596032060943 4005 6739575
SGTC_2256 7954252 200 µM -0.971883841227784 0.144957766050893 no 2880 0.165554169722473 4081 2972920
SGTC_926 2268-1401 59.4 µM -0.97245930446652 0.144809418699319 no 2881 0.165411050496414 4019 2931578
SGTC_1804 st050076 49.1 µM -0.974320019241756 0.144330449194063 no 2882 0.164948833845301 4092 3895976
SGTC_1803 st050068 52.4 µM -0.976488650178382 0.143773567402365 no 2883 0.164411184812531 4130 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_246 cycloheximide 667 µM -0.976790880289363 0.14369607311882 no 2884 0.164336345932592 3947 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1375 2910-0797 186 µM -0.977889749402684 0.143414551633155 no 2885 0.164064427736831 4073 742508
SGTC_1070 indatraline 8.81 µM -0.978699985611288 0.143207214260705 no 2886 0.163864119600526 4075 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_37 0566-0070 1.56 µM -0.979069962323348 0.143112605533159 no 2887 0.163772706058133 4041 1626686
SGTC_2979 9012552 45.46 µM -0.979393866026492 0.143029813053459 no 2888 0.163692703376475 4089 17100905
SGTC_980 1473-0395 201 µM -0.981240294749774 0.142558468651338 no 2889 0.163237128856013 3947 768876
SGTC_3055 9094636 49.47 µM -0.982385752588712 0.1422665921071 no 2890 0.162954921317198 4100 25236176
SGTC_1784 st039334 36.3 µM -0.982876388799469 0.142141695830106 no 2891 0.162834139893767 4146 3496984
SGTC_3229 9132204 49.47 µM -0.982921430357864 0.142130233778149 no 2892 0.162823054793182 4116 17682924
SGTC_119 0121-0043 24.815 µM -0.984245705739809 0.141793515381176 no 2893 0.16249735898109 4077 1092378
SGTC_2885 9057732 51.95 µM -0.984670394180147 0.14168564598851 no 2894 0.162392999816096 4152 6471414
SGTC_1401 3807-4679 7.6 µM -0.986166959461538 0.141305966751221 no 2895 0.16202559494579 4014 3291456
SGTC_596 1155-0152 116 µM -0.989148742368779 0.140551544770573 no 2896 0.161295186323509 4072 280313
SGTC_2734 clemastine 41.6 µM -0.989593877356133 0.140439155991177 no 2897 0.161186331919013 4107 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1093 fluphenazine 7.97 µM -0.990416831053199 0.140231535331354 no 2898 0.1609852110424 4076 6602611 An atypical antipsychotic.
SGTC_1307 1187-1599 12.2 µM -0.990799603374141 0.140135037856222 no 2899 0.160891721508157 4056 1538471
SGTC_1798 st045719 60.953 µM -0.99101834052047 0.14007991415378 no 2900 0.160838312365864 3957 3980186
SGTC_2090 5301565 104.445 µM -0.992081357616789 0.139812234192234 no 2901 0.160578919861424 4082 2056344
SGTC_1609 st001574 46.4 µM -0.992131416790152 0.139799637293443 no 2902 0.160566711394784 4066 3960012
SGTC_2067 5224629 34.075 µM -0.992307477936752 0.139755339365537 no 2903 0.160523778293956 4093 2835000
SGTC_471 1-acyl-paf 4 µM -0.994068372268993 0.139312813915298 no 2904 0.16009479094021 4003 16759367
SGTC_984 1492-0255 2.91 µM -0.994333645134346 0.139246231651537 no 2905 0.160030230449762 4058 1585198
SGTC_2867 9039098 71.43 µM -0.994402554055731 0.139228939374259 no 2906 0.160013462603144 4040 6463460
SGTC_332 4112-0506 40.9 µM -0.995256891851879 0.139014669838228 no 2907 0.159805669053072 4029 2790355
SGTC_3304 9125678 46.087 µM -0.995638567053847 0.138919017559938 no 2908 0.159712894409415 4015 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2105 5350118 200 µM -0.997621901951412 0.138422692149438 no 2909 0.159231368253214 4073 2133313
SGTC_2497 7-hydroxyflavone 100 µM -0.998727126116566 0.138146637106009 no 2910 0.158963448168643 4114 5281894
SGTC_1052 3253-3998 198 µM -1.00019533556595 0.137780499103474 no 2911 0.158607993059354 4022 5450317
SGTC_1628 st004252 77.7 µM -1.00026445280703 0.137763279171751 no 2912 0.158591272555286 4118 692968
SGTC_2482 5981709 142.65 µM -1.00059918612592 0.137679904189519 no 2913 0.158510311867094 4044 877755
SGTC_346 4513-0042 7.16 µM -1.00097858742448 0.137585445003149 no 2914 0.158418580282949 4071 2827372
SGTC_3279 9140807 49.47 µM -1.00326609767732 0.137016863184649 no 2915 0.157866244506365 4127 45595718
SGTC_2830 7992007 71.43 µM -1.00496580720074 0.136595425796116 no 2916 0.157456657360247 3978 1952075
SGTC_2120 5538279 151.968 µM -1.00578219559052 0.13639332043585 no 2917 0.157260176851285 4060 2058197
SGTC_2759 disulfiram 3.38 µM -1.00579650657694 0.136389779429044 no 2918 0.157256734058906 3997 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1767 st044992 70.3 µM -1.00664710345487 0.136179426848555 no 2919 0.157052195068568 4139 9600693
SGTC_509 pifithrin 175 µM -1.00695778004797 0.136102651922634 no 2920 0.156977531791477 4158 4817 A p53 inhibitor.
SGTC_476 mead acid 10 µM -1.00958564544199 0.135454434521039 no 2921 0.156346924880401 4125 5312531 An omega 9 fatty acid.
SGTC_3333 9141820 12.094 µM -1.01019539704619 0.135304329568511 no 2922 0.156200842063101 4091 1939433
SGTC_1675 st018485 24.5 µM -1.01272723311296 0.134682277429567 no 2923 0.1555952330932 4150 3323024
SGTC_2141 5621638 7.665 µM -1.01337217659768 0.134524134050775 no 2924 0.155441212039198 4129 2856238
SGTC_2895 9054447 58.44 µM -1.01494753594331 0.134138384149446 no 2925 0.155065418443934 4166 2697450
SGTC_1056 3448-1962 115 µM -1.01535205725184 0.134039453891211 no 2926 0.154969018913938 4108 715507
SGTC_720 r052-1644 49.9 µM -1.01546953829565 0.134010731970229 no 2927 0.154941029988441 4134 1422863 YOR257W CDC31
SGTC_660 4031-1742 102 µM -1.01611352156919 0.133853365214496 no 2928 0.154787665402069 4005 6738706
SGTC_2812 7970281 58.44 µM -1.01657630407664 0.133740355985408 no 2929 0.154677515721467 4157 2233435
SGTC_401 neomycin 50 µM -1.0188949341859 0.133175145497251 no 2930 0.15412642447352 4072 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1690 st023502 41.2 µM -1.02206360553487 0.13240538278357 no 2931 0.153375398557244 4114 24207482
SGTC_1152 3909-8331 15.9 µM -1.02405054879091 0.131924263448116 no 2932 0.152905699931391 4073 16001939
SGTC_2267 7931562 200 µM -1.02451646329396 0.131811621452005 no 2933 0.152795699392554 4056 934880
SGTC_1833 st055984 71 µM -1.0267238879982 0.131278844595338 no 2934 0.152275248817011 4134 676288
SGTC_2565 isoliquiritigenin 100 µM -1.02694602240482 0.131225313428903 no 2935 0.152222940829296 4217 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1680 diphenhydramine 100 µM -1.02726646906593 0.131148117000098 no 2936 0.15214750339065 4110 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_998 3996-0085 177 µM -1.0298114389687 0.130536140999568 no 2937 0.151549264955574 4151 715391
SGTC_741 4582-0002 126 µM -1.03065359591704 0.130334067333591 no 2938 0.151351646467328 4106 2912688
SGTC_2875 9039966 71.43 µM -1.03074198550607 0.130312871005341 no 2939 0.151330915124726 4133 6463691
SGTC_2155 5570423 76 µM -1.03150528852214 0.13012992580014 no 2940 0.15115196474108 4075 797402
SGTC_2071 5230951 39.92 µM -1.03150570845321 0.130129825201799 no 2941 0.151151866330311 4160 1799272
SGTC_2607 solasodine 47.35 µM -1.03356368192279 0.12963746506834 no 2942 0.15067009260463 4108 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_331 k048-0133 24.5 µM -1.03431908745137 0.129457062135489 no 2943 0.150493508230252 4092 6813582
SGTC_2774 tamoxifen 10.92 µM -1.03711308037932 0.128791323755726 no 2944 0.149841579924183 4116 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2372 9071633 200 µM -1.03741198307192 0.128720243634207 no 2945 0.149771948026331 4153 21321366
SGTC_262 fenpropimorph 62.5 µM -1.0378379252826 0.128619000100081 no 2946 0.149672758505097 4093 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_192 3455-0609 60.9 µM -1.03805474701882 0.128567484294484 no 2947 0.149622283882232 4196 3769639
SGTC_2801 7907800 81.82 µM -1.0387848277537 0.128394125906738 no 2948 0.14945240958001 4147 6620925
SGTC_1720 st037298 9.481 µM -1.03986724341559 0.128137404006621 no 2949 0.149200791416826 4148 597396
SGTC_603 3794-0023 45.9 µM -1.04129410805447 0.127799532500728 no 2950 0.148869535195558 4178 3802260
SGTC_1897 st060201 15 µM -1.04129873793946 0.127798437185269 no 2951 0.148868461137153 4179 611878
SGTC_783 0848-0141 92.7 µM -1.04180283511927 0.127679219373796 no 2952 0.148751549721857 4063 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_409 arachidonic acid 100 µM -1.04307116839318 0.127379603529392 no 2953 0.148457666361227 4132 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1706 st031321 9.9705 µM -1.04373962857759 0.127221891441294 no 2954 0.148302934933323 4150 6103185
SGTC_1949 st076024 69.1 µM -1.04481728539978 0.126967922336984 no 2955 0.148053712182711 4068 2921930
SGTC_13 0199-0087 65 µM -1.04552730988066 0.126800785335933 no 2956 0.147889662659604 4193 4589825
SGTC_413 propylparaben 100 µM -1.04658166642237 0.126552876639597 no 2957 0.147646280611813 4081 7175 A pharmaceutical preservative.
SGTC_1879 gemcitabine 100 µM -1.04743172577035 0.126353249900349 no 2958 0.147450252882159 4111 60750 A nucleoside analog which inhibits DNA replication.
SGTC_20 0481-0013 4.944 µM -1.04884881652405 0.126020950297514 no 2959 0.147123852842351 4166 182045
SGTC_2146 5545642 200 µM -1.05004929714528 0.125739921648618 no 2960 0.146847724135906 4098 825326
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.05409536139643 0.124795972007818 no 2961 0.1459196298355 4187 6708784 An antioxidant flavonoid
SGTC_3285 9112818 20.8695 µM -1.05409734056555 0.12479551148125 no 2962 0.14591917681639 4115 17017947 YPR165W RHO1
SGTC_1655 st012546 55.1 µM -1.05439908560997 0.124725313278503 no 2963 0.145850120368406 4143 720985 YLR208W SEC13
SGTC_897 1000-0139 31.4 µM -1.05469655106885 0.124656137698433 no 2964 0.145782064835639 4109 6151020
SGTC_520 3584-0023 682 µM -1.05493189852078 0.124601426662918 no 2965 0.145728236076344 4147 1340790
SGTC_1569 carminic acid 40.6 µM -1.05639162336877 0.124262460507559 no 2966 0.145394665709927 4238 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2172 5754775 163.918 µM -1.05758263703027 0.123986370634607 no 2967 0.145122880898989 4113 2263357
SGTC_1359 1582-0056 520 nM -1.05784827239886 0.123924852071242 no 2968 0.14506231057626 4206 3661189
SGTC_2272 7805186 180 µM -1.05808406466335 0.123870262780603 no 2969 0.14500855935207 4164 2956062 YPR165W RHO1
SGTC_1457 k015-0032 57.3 µM -1.05847575029267 0.123779619147216 no 2970 0.144919300300086 4149 4302660
SGTC_1049 3226-0134 66 µM -1.06023387907998 0.123373326164604 no 2971 0.14451910586999 4194 5702385
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.06267639112918 0.122810428370305 no 2972 0.143964365438457 4160 66535 A nucleotide analog.
SGTC_2386 9075165 157.42 µM -1.06356363735399 0.122606401531482 no 2973 0.143763211208848 4130 16452277
SGTC_496 calpeptin 138 µM -1.06548266228618 0.122165925548717 no 2974 0.14332878365026 4173 73364 A calpain inhibitor.
SGTC_2240 6690706 185.951 µM -1.07605455853613 0.11975926742943 no 2975 0.140951428415883 4033 805876
SGTC_944 3370-0224 231 µM -1.07756545503771 0.119418066176362 no 2976 0.140613862752385 4200 4580514
SGTC_1125 tnp00248 1.32998 µM -1.07775451730191 0.119375419141564 no 2977 0.14057166097471 4248 24207736
SGTC_1723 st034307 2.5525 µM -1.0787086347573 0.119160361528446 no 2978 0.140358817594745 4196 867466
SGTC_2735 sertaconazole 140 nM -1.07991975836672 0.118887768966957 no 2979 0.140088956943314 4303 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_148 3253-0744 288.01 µM -1.08474569705737 0.117805949880621 no 2980 0.139017151207558 4061 6893655
SGTC_573 3702-0553 84.7 µM -1.08508566709643 0.117730003112712 no 2981 0.138941857396395 4128 1222756
SGTC_2653 dihydrofissinolide 100 µM -1.08543068844118 0.117652963354428 no 2982 0.138865473255446 4213 6857746
SGTC_1016 4226-1401 38 µM -1.08600286956082 0.117525279798573 no 2983 0.138738861344181 4137 2901613
SGTC_2197 6588183 93.1375 µM -1.08647929621991 0.117419038950851 no 2984 0.138633497934531 4130 884136
SGTC_2480 5767542 37.17 µM -1.0877642324124 0.117132843479475 no 2985 0.138349601656138 4128 2867358
SGTC_1155 4088-0394 48.2 µM -1.08842084830481 0.116986785539515 no 2986 0.138204680768538 4139 2326248
SGTC_1648 st011736 69.8 µM -1.08926706332147 0.116798743496208 no 2987 0.138018066383365 4176 2855514
SGTC_2528 xanthyletin 44.79 µM -1.08950245430585 0.116746474096966 no 2988 0.137966186568765 4211 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2383 9036125 200 µM -1.09248808071781 0.116084944004335 no 2989 0.137309313331796 4110 79580
SGTC_3077 9117319 49.47 µM -1.09278867561946 0.116018488425356 no 2990 0.137243297428541 4161 17154678
SGTC_2945 9067681 61.76 µM -1.09316616961219 0.115935070240706 no 2991 0.137160423849707 4258 16456930
SGTC_34 0469-0683 81.75 µM -1.09329903096936 0.115905720825968 no 2992 0.137131264113374 4143 3690923
SGTC_1660 st012960 28.1 µM -1.09400022068036 0.115750913609191 no 2993 0.136977440712273 4195 24207266
SGTC_2062 5245942 200 µM -1.09429258305345 0.115686409846863 no 2994 0.136913338599132 4235 1376160
SGTC_483 fpl-64176 144 µM -1.09432444602122 0.115679381479676 no 2995 0.136906353701377 4274 3423
SGTC_2173 5763948 167 µM -1.09487495423863 0.115557997680792 no 2996 0.136785711506131 4167 2867177
SGTC_1042 0350-0096 82 µM -1.0954523056412 0.115430792366497 no 2997 0.136659264805673 4172 3122515
SGTC_481 bay k-8644 50 µM -1.09600061635967 0.115310077614531 no 2998 0.136539252370794 4170 2303 A calcium channel antagonist.
SGTC_2404 5161160 200 µM -1.09642453937987 0.115216809279974 no 2999 0.136446514924446 4132 2831543
SGTC_1266 0828-0227 32.9 µM -1.09659587382915 0.115179128793213 no 3000 0.136409046010022 4178 3913820
SGTC_878 0828-0289 13.7 µM -1.09666753803446 0.115163370742984 no 3001 0.136393375943336 4130 745350 YLR208W SEC13
SGTC_677 0929-0063 136 µM -1.09908377336857 0.114632968026575 no 3002 0.135865763502897 4171 1539583
SGTC_1617 st002906 78 µM -1.10201199396387 0.113992509210271 no 3003 0.135228228659213 4181 5150859
SGTC_2111 5486399 200 µM -1.1031354280046 0.113747470252851 no 3004 0.13498417881958 4164 689674
SGTC_1028 k015-0029 4.8 µM -1.1059322519414 0.113139069550045 no 3005 0.134377921945585 4148 4588309
SGTC_2040 5100729 123 µM -1.1064974745009 0.11301639771986 no 3006 0.134255628264726 4222 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1104 tacrolimus 29.8 µM -1.11752465304803 0.11064210640882 no 3007 0.131885032348813 4265 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2779 methotrexate 400 µM -1.11753541252135 0.110639807349749 no 3008 0.131882733493326 4231 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2153 5569715 200 µM -1.11852707746849 0.110428057685974 no 3009 0.131670974280635 4247 2054701
SGTC_2455 5377712 9.75 µM -1.12010112387475 0.110092549327785 no 3010 0.131335335885168 4204 2243908
SGTC_3134 9127454 49.47 µM -1.12088128206073 0.109926529744305 no 3011 0.131169199689638 4269 24262820
SGTC_714 4296-0578 26.1 µM -1.12148455894223 0.109798274170323 no 3012 0.131040830274282 4248 1589775
SGTC_2009 4012297 12.05 µM -1.12403877169182 0.109256443253296 no 3013 0.13049828909299 4206 45595307
SGTC_209 4077-0173 175.592 µM -1.12548264789618 0.108951001772998 no 3014 0.130192283081424 4194 15993494
SGTC_1393 3470-5649 58.2 µM -1.12719846047457 0.108588832849702 no 3015 0.129829290632648 4202 4108395
SGTC_1198 1612-1005 86.7 µM -1.12909170750514 0.108190217397616 no 3016 0.129429574557948 4293 6998509
SGTC_3070 9117005 49.47 µM -1.1294615272945 0.108112476469675 no 3017 0.129351595175802 4302 8779016
SGTC_2900 5328528 85.29 µM -1.13540182527279 0.106869255650429 no 3018 0.128103497630624 4245 795359
SGTC_1311 1190-0148 100 µM -1.13719297120383 0.106496425834417 no 3019 0.127728812322234 4276 1961333
SGTC_2696 st077691 74.316 µM -1.1374542940523 0.106442109668175 no 3020 0.12767421059289 4288 757133
SGTC_1572 epiandrosterone 68.9 µM -1.14008788811974 0.105895831269821 no 3021 0.127124843699947 4158 441302 A steroid.
SGTC_2227 7312221 64.1025 µM -1.15007459664841 0.103842731804104 no 3022 0.125056574140643 4337 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1337 1486-1011 40.3 µM -1.15218397285887 0.103412797682331 no 3023 0.124622741100537 4205 X1337
SGTC_1051 3253-3903 78 µM -1.15368793007767 0.103107050388937 no 3024 0.124314067039083 4225 5509239
SGTC_1749 st037932 54.2 µM -1.15387865880215 0.103068323111444 no 3025 0.124274959875977 4274 594497
SGTC_3015 9080845 49.47 µM -1.1539579320123 0.103052229873663 no 3026 0.124258708168268 4280 5296973
SGTC_1995 st072814 61.1 µM -1.15526986617526 0.102786159395148 no 3027 0.123989965942869 4197 5769371
SGTC_2294 7971431 200 µM -1.1555719249198 0.102724970289138 no 3028 0.123928148580968 4238 5741572
SGTC_1234 0326-0494 15.5 µM -1.15584783309025 0.102669101735558 no 3029 0.123871701877006 4329 1547813
SGTC_678 1218-2179 85.9 µM -1.15741979423934 0.10235121716345 no 3030 0.12355044537668 4262 6820081 YOR116C RPO31
SGTC_1725 st036284 20.55 µM -1.15755289361833 0.102324334492501 no 3031 0.123523271116497 4300 707914
SGTC_1960 st011366 51.8 µM -1.15819921880145 0.102193866343191 no 3032 0.123391373531721 4258 3972846
SGTC_1241 0364-0022 50.8 µM -1.15896343743035 0.102039756234991 no 3033 0.123235544408971 4259 4563895
SGTC_2432 5630864 12.22 µM -1.16164877763541 0.101499579471185 no 3034 0.122689080019744 4289 5714970
SGTC_555 4296-0685 37 µM -1.16182113969028 0.101464978788737 no 3035 0.122654062635012 4227 2908540 YHR072W ERG7
SGTC_2036 5160441 105 µM -1.16308890309882 0.101210746596939 no 3036 0.122396716969495 4218 134534 YIL048W NEO1
SGTC_3092 9117248 49.47 µM -1.16343293134667 0.101141836692147 no 3037 0.122326947448139 4385 17141857
SGTC_1057 3448-5381 134 µM -1.16974081842942 0.0998844031147197 no 3038 0.121052643170436 4244 5497911
SGTC_171 k064-0041 9.68 µM -1.17115474422244 0.0996041200686502 no 3039 0.120768291184429 4278 53325
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.17281628771704 0.099275486705617 no 3040 0.120434742528249 4239 442882
SGTC_3023 9089636 49.47 µM -1.17440342940737 0.0989623101308862 no 3041 0.120116736145296 4338 17249241
SGTC_3307 9126885 69.2785 µM -1.17461951519306 0.0989197278027902 no 3042 0.12007348609687 4216 24824909
SGTC_160 3453-0671 289.699 µM -1.17614935625909 0.0986186373989697 no 3043 0.119767598914561 4298 5322268
SGTC_125 0133-0007 11.75 µM -1.17930132981962 0.0980004085641922 no 3044 0.119139104464224 4348 26541
SGTC_2304 7443016 91.4 µM -1.1804116739454 0.0977833032517626 no 3045 0.118918260573764 4196 939854
SGTC_877 0771-0151 33.1 µM -1.18086614808556 0.0976945418005777 no 3046 0.118827950558458 4287 6166523
SGTC_2872 9044037 25.97 µM -1.18171413508648 0.0975290829613077 no 3047 0.11865957388292 4297 6465195
SGTC_441 propafenone 146 µM -1.18280171947065 0.0973171749338516 no 3048 0.118443869485985 4255 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_985 1493-0307 8.71 µM -1.18443707699208 0.0969991733820945 no 3049 0.118120045278678 4288 3278274
SGTC_2529 gangaleoidin 93.61 µM -1.18590424780909 0.0967145261237371 no 3050 0.117830057736333 4288 4565183
SGTC_991 3996-0057 64.7 µM -1.18625582672453 0.0966464071610255 no 3051 0.117760642753302 4331 715343
SGTC_1065 prochlorperazine maleate 2.48 µM -1.18645454881198 0.0966079200394355 no 3052 0.117721420296716 4314 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_95 0471-0001 561.058 µM -1.18894496745421 0.096126547265628 no 3053 0.117230661715014 4272 4015405
SGTC_1245 0418-0076 17.2 µM -1.19101257759634 0.0957282407337545 no 3054 0.116824323644157 4305 6790114
SGTC_2145 5634607 200 µM -1.19580392456057 0.0948099003098977 no 3055 0.115886542031122 4256 308662
SGTC_1614 st002383 48.6 µM -1.19747665088566 0.0944908284679748 no 3056 0.115560411523193 4313 1947235
SGTC_1473 k844-0725 134 µM -1.19809995632187 0.0943721359118908 no 3057 0.115439052931677 4330 54682906
SGTC_781 4335-2806 94.4 µM -1.20010890039506 0.0939903322490618 no 3058 0.115048524665332 4343 845254
SGTC_921 1561-0023 372 µM -1.20520347400236 0.093027211450476 no 3059 0.114062380801067 4260 24050882
SGTC_3254 9136651 49.47 µM -1.20782542428237 0.0925343884828334 no 3060 0.113557209924818 4239 16454030
SGTC_1190 1486-1332 13 µM -1.20825302457287 0.0924542000597439 no 3061 0.113474975751872 4281 4150046
SGTC_1187 1391-0724 117 µM -1.20864969408432 0.0923798581070627 no 3062 0.113398728025649 4332 6997986
SGTC_2339 9000433 200 µM -1.21607287005123 0.0909967900268506 no 3063 0.111978582144067 4311 2988954
SGTC_1692 fluoroquinolonic acid 71 µM -1.21646009801226 0.0909250664721762 no 3064 0.111904851172012 4314 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1242 0402-0103 60.1 µM -1.21736330505815 0.0907579346989437 no 3065 0.11173300903414 4227 432868
SGTC_554 4483-2211 187 µM -1.21747787250392 0.0907367511453653 no 3066 0.111711225187449 4357 747107
SGTC_315 k915-0449 187 µM -1.21877542594726 0.0904970892032476 no 3067 0.111464720493023 4313 20970215 YNL149C PGA2
SGTC_2353 9059630 146.67 µM -1.2203786329679 0.0902016216131471 no 3068 0.111160686734314 4342 4779114
SGTC_172 1112-0046 2.638 µM -1.22119533048972 0.0900513817997863 no 3069 0.111006035906953 4285 2802135 YIL048W NEO1
SGTC_1741 st038134 10.228 µM -1.22488667746037 0.0893746398472363 no 3070 0.110308960353659 4368 1272587
SGTC_2484 5809818 12.04 µM -1.22662837667111 0.0890566474359637 no 3071 0.109981149345951 4267 2870548
SGTC_1982 st072467 71.9 µM -1.22815655204436 0.088778333580465 no 3072 0.109694102588193 4283 3163533
SGTC_2343 7990716 14.84 µM -1.22989059850177 0.0884633111583277 no 3073 0.109369037639175 4313 6456862
SGTC_993 3909-8757 62.7 µM -1.2315372106503 0.0881649444676851 no 3074 0.109061004189392 4248 4288324 YLR208W SEC13
SGTC_3159 9100096 49.47 µM -1.23195383087377 0.0880895717881644 no 3075 0.108983165544542 4242 25236875
SGTC_3158 9100007 49.47 µM -1.24498877336897 0.085755559119736 no 3076 0.1065679384961 4337 19297233
SGTC_1227 3909-8010 46.6 µM -1.24865146003052 0.0851081316182165 no 3077 0.105896290899795 4313 15982272
SGTC_1372 2752-0194 270 µM -1.24879060523561 0.0850836083150442 no 3078 0.105870835512876 4263 823334
SGTC_2171 5739187 198.077 µM -1.24929543063921 0.0849946810671323 no 3079 0.105778519291114 4259 2262761
SGTC_850 0388-0143 75.9 µM -1.25226328794981 0.0844732880087289 no 3080 0.105236970753276 4305 67273
SGTC_2152 5568786 200 µM -1.25508486895829 0.0839798213764329 no 3081 0.104723976338834 4344 5399883
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.25569326121246 0.0838737038325786 no 3082 0.104613601692783 4288 2333 A French combination drug.
SGTC_454 lyso-paf C-16 6.67 µM -1.2654115442389 0.0821922384004613 no 3083 0.102861919526579 4356 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3220 9131269 49.47 µM -1.26543948809501 0.0821874404126283 no 3084 0.102856913672935 4352 17722206
SGTC_3019 9081971 49.47 µM -1.26680458338465 0.0819533089965 no 3085 0.102612586420946 4352 16451803
SGTC_2033 5192550 145 µM -1.26749755840966 0.0818346473523713 no 3086 0.10248871804466 4342 182073
SGTC_1154 4088-0362 150 µM -1.26817981980923 0.0817179468076582 no 3087 0.102366870957335 4341 6618304
SGTC_2100 5377183 190 µM -1.26900174914068 0.0815775227777685 no 3088 0.102220220103949 4353 2844202
SGTC_1292 0kpi-0043 232 µM -1.26961846634513 0.0814722781274557 no 3089 0.102110284147638 4362 3333905
SGTC_2623 humulene 100 µM -1.27166150318705 0.0811243591880131 no 3090 0.101746707106863 4342 6187145 An anti-inflammatory.
SGTC_1025 k007-0731 70 µM -1.27189853827575 0.0810840659957205 no 3091 0.101704585642992 4308 6256118
SGTC_2300 7976697 71.57 µM -1.27411622186301 0.0807078171146872 no 3092 0.101311115102369 4237 2236109
SGTC_2715 st079500 56.4 µM -1.27664299673324 0.0802807368383718 no 3093 0.100864157351418 4322 28246688
SGTC_2793 7325131 81.82 µM -1.27780001145044 0.0800857470437003 no 3094 0.100659975185821 4284 4176441
SGTC_233 rapamycin 362 pM -1.28263758967191 0.0792743544375007 no 3095 0.0998095371880994 4334 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3005 9076496 71.4286 µM -1.28937622688133 0.0781544957464573 no 3096 0.098633661037512 4326 21368410
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.28947949229575 0.0781374284486036 no 3097 0.0986157206962763 4375 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2800 7887935 81.82 µM -1.28968771089928 0.0781030235019387 no 3098 0.0985795540600889 4363 2961002
SGTC_414 piperonyl butoxide 100 µM -1.28990952726058 0.0780663843767315 no 3099 0.0985410362371577 4354 5794 A potent inhibitor of cytochrome P450.
SGTC_1583 clindamycin 39.6 µM -1.2930947851241 0.0775416877273426 no 3100 0.097989139275029 4327 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1515 3460-0031 42.1 µM -1.29620576463773 0.0770318158456276 no 3101 0.0974523020206759 4314 2876596
SGTC_1460 k062-0059 9.15 µM -1.29710182547904 0.0768854302474084 no 3102 0.0972980767590655 4250 1373085
SGTC_260 nsc-65238 3.989 µM -1.2976775352214 0.0767914906704994 no 3103 0.0971990831692134 4353 3246252
SGTC_2244 6635614 200 µM -1.30049918104654 0.0763323393242287 no 3104 0.0967149683862839 4301 836499
SGTC_2534 helenine 20.12 µM -1.30067307673378 0.0763041106962575 no 3105 0.0966851908304686 4382 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2395 5646831 180.19 µM -1.30540471890293 0.0755390646275216 no 3106 0.0958775361947558 4371 6808628
SGTC_2712 st079126 47.7 µM -1.30801479828209 0.0751195569636769 no 3107 0.09543414502402 4362 3152970
SGTC_924 2046-0044 21.3 µM -1.30839631789826 0.0750583859432968 no 3108 0.0953694604436597 4358 3623589
SGTC_3302 9125395 16.351 µM -1.30995138896379 0.0748094462576473 no 3109 0.0951061404563627 4313 17599668
SGTC_657 3534-0529 86.7 µM -1.31217610552832 0.0744544039108317 no 3110 0.0947303610296644 4412 1049549
SGTC_1539 benzyladenosine 56 µM -1.31439702847578 0.074101251533863 no 3111 0.0943563149704647 4379 92208 A nucleotide analog.
SGTC_2228 7354201 200 µM -1.31477957373395 0.074040551819977 no 3112 0.0942919971178193 4461 753451
SGTC_2047 4141938 200 µM -1.31917916316424 0.0733451825656095 no 3113 0.0935546113132809 4390 3807862
SGTC_82 0054-0107 293.755 µM -1.31957159236334 0.0732834013458373 no 3114 0.0934890463200113 4336 3104697
SGTC_1046 2001-0062 216 µM -1.32035474854616 0.0731602259012313 no 3115 0.0933583021852673 4317 739778
SGTC_307 1501-1223 22.3 µM -1.32224945439223 0.0728628802988148 no 3116 0.0930425490042041 4406 2830329
SGTC_2622 2-methoxyxanthone 59.94 µM -1.32521253303639 0.072399725615607 no 3117 0.0925503348180727 4359 71034 A hepatoprotective.
SGTC_1240 0356-0016 42.1 µM -1.32905392502007 0.0718026448216781 no 3118 0.0919150898463642 4356 4305613
SGTC_1163 k060-0048 49.9 µM -1.32945508449498 0.0717405096565839 no 3119 0.0918489374084624 4381 6809982
SGTC_2134 5324836 1.464 µM -1.3297698033947 0.071691792057821 no 3120 0.0917970639789826 4358 699272
SGTC_748 act1.228 77.9 µM -1.33033052798985 0.0716050563649513 no 3121 0.0917046965309567 4357 4421505 YNR035C ARC35
SGTC_2465 5809242 33.21 µM -1.33168462370727 0.0713959300379355 no 3122 0.0914819220228292 4444 2731748
SGTC_3022 9087993 49.47 µM -1.33258537322446 0.0712570782672371 no 3123 0.0913339538977421 4470 17173644
SGTC_3243 9134147 49.47 µM -1.33260620853725 0.0712538689301419 no 3124 0.0913305333353723 4477 24282180
SGTC_1683 st010134 710 nM -1.33523256152516 0.070850210394645 no 3125 0.0909001214194706 4370 3818134
SGTC_145 3737-0113 38.366 µM -1.33576458458751 0.0707686552636867 no 3126 0.0908131160273267 4364 6849351
SGTC_2051 5263410 176 µM -1.33730306202443 0.0705332241240467 no 3127 0.0905618659560795 4357 227584
SGTC_1156 4092-0367 4.88 µM -1.34182034043083 0.069845429724806 no 3128 0.0898271276897603 4440 1357585
SGTC_847 0342-0274 5.54 µM -1.35018925122616 0.0685848456595579 no 3129 0.0884776425732954 4393 18097
SGTC_721 1187-1332 279 µM -1.3504235109646 0.0685498139727696 no 3130 0.0884400867555185 4373 25730
SGTC_820 1582-0060 59.9 µM -1.35044283201094 0.0685469252796982 no 3131 0.0884369897936855 4428 3848840
SGTC_870 0573-2213 57.6 µM -1.35094871001375 0.0684713247792363 no 3132 0.0883559315882912 4397 3916321
SGTC_2865 9030313 51.95 µM -1.3528329723824 0.06819029872678 no 3133 0.0880544982556138 4381 42562754
SGTC_3172 9105863 49.47 µM -1.35399692323316 0.0680171480051854 no 3134 0.0878686796598458 4494 2348785
SGTC_1943 st076331 65.2 µM -1.35412359959988 0.0679983239782898 no 3135 0.0878484741079687 4400 24208415
SGTC_1045 1348-1485 165 µM -1.35735459828915 0.0675195581035211 no 3136 0.0873342834434773 4376 6810614
SGTC_208 k072-0098 12.366 µM -1.35962296175736 0.0671849937967103 no 3137 0.0869746340403573 4390 5948901
SGTC_1608 st001473 40.5 µM -1.36215249133048 0.0668134229762335 no 3138 0.0865748827351471 4353 7292267
SGTC_1734 st037168 69.4 µM -1.36240150371998 0.0667769308712134 no 3139 0.0865356047254632 4419 708907
SGTC_912 3474-0017 2.18 µM -1.36300663491601 0.0666883147770638 no 3140 0.0864402097816618 4428 3360550
SGTC_438 sphingosine 6.67 µM -1.36423947747702 0.0665080575266853 no 3141 0.0862461035861588 4335 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1195 1502-0147 41.1 µM -1.36601180032946 0.0662495825630394 no 3142 0.0859676298121983 4398 817940
SGTC_2537 larixol 68.93 µM -1.36744293338368 0.0660414349146639 no 3143 0.0857432564525779 4388 6708759
SGTC_3156 9099931 49.47 µM -1.37330642507696 0.0651939205325771 no 3144 0.0848285530148921 4460 18111053
SGTC_2695 st077686 51.995 µM -1.38208679003039 0.0639406099766378 no 3145 0.083472527028201 4408 2876092
SGTC_1415 3966-0071 78.1 µM -1.38226504881574 0.0639153607314253 no 3146 0.0834451667386239 4327 2893185
SGTC_3256 9138902 49.47 µM -1.38319692588355 0.0637834923555816 no 3147 0.0833022460412515 4526 17228773
SGTC_543 3844-1095 191 µM -1.38970792037996 0.0628680292490676 no 3148 0.0823087943629268 4436 4230703
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.3904895855137 0.0627588168357132 no 3149 0.0821901298075611 4499 4620898
SGTC_1326 1431-2094 10.8 µM -1.39119412433026 0.0626605070645899 no 3150 0.0820832842524811 4432 616278
SGTC_1264 0783-0040 158 µM -1.39248977418838 0.0624800283592614 no 3151 0.0818870680361627 4351 2855798
SGTC_643 k048-0106 28.4 µM -1.39376131770606 0.0623033018695397 no 3152 0.0816948464220573 4447 6763920
SGTC_3169 9102970 49.47 µM -1.39778945943573 0.0617460203668214 no 3153 0.0810881502778894 4512 17027839
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.40238778439962 0.0611146208220113 no 3154 0.0803997395719993 4503 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1842 st055362 61.2 µM -1.40410539225554 0.0608800734014983 no 3155 0.0801437340761457 4397 676032
SGTC_92 0063-0024 660.874 µM -1.40607475633505 0.0606120142528989 no 3156 0.0798509637203372 4540 3594437
SGTC_2775 cyproheptadine 69.59 µM -1.40700276556704 0.0604860191387301 no 3157 0.0797132843553199 4439 2913 A selective serotonin reuptake inhibitor.
SGTC_2624 nerol 100 µM -1.4092216418764 0.0601855947415214 no 3158 0.079384820152934 4355 637566 A natural product oil.
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.40954711389859 0.0601416259200336 no 3159 0.0793367262306432 4402 2724 A muscle relaxant with antifungal properties.
SGTC_3035 9091303 49.47 µM -1.41138149281075 0.0598942852510125 no 3160 0.0790660785061328 4518 25237002
SGTC_1488 4013-0813 75.9 µM -1.41288273037072 0.0596924575318026 no 3161 0.0788451038323316 4422 2910057
SGTC_392 N-ethylmaleimide 8.33 µM -1.41392180252567 0.059553076082545 no 3162 0.0786924318118487 4397 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_278 4092-0821 23.9 µM -1.41855802499093 0.0589342775878593 no 3163 0.0780139553341009 4449 877900
SGTC_17 0960-0276 49.807 µM -1.41939215610497 0.0588234831536549 no 3164 0.0778923589852172 4445 6821114
SGTC_1471 k673-0312 37 µM -1.42593264375252 0.0579603919913069 no 3165 0.0769438927929652 4427 24099884
SGTC_970 1315-0089 19.5 µM -1.42916426588774 0.0575376327897461 no 3166 0.0764785128646176 4416 6811083 YLR033W RSC58
SGTC_460 trequinsin 123 µM -1.4291926710131 0.0575339276276175 no 3167 0.0764744318096762 4539 5537 A vasodilator.
SGTC_2059 5238311 157 µM -1.42942846883814 0.057503177424316 no 3168 0.076440560379857 4409 703021
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.43079318251817 0.0573254600837067 no 3169 0.0762447487767295 4486 16486 A toxic proline analog.
SGTC_1819 st053448 58.6 µM -1.43525006063208 0.0567480803969817 no 3170 0.0756079264592048 4387 2857616
SGTC_3053 9095903 49.47 µM -1.43707359187194 0.0565131701394989 no 3171 0.075348541999794 4567 17174018
SGTC_2601 securinine 100 µM -1.4465290544047 0.0553073672381992 no 3172 0.0740144344342067 4425 442872 A GABA receptor antagonist.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.45096839355217 0.054748296479585 no 3173 0.0733943307229856 4507 91467 include heat shock
SGTC_3163 9099914 49.47 µM -1.451157955917 0.0547245236571211 no 3174 0.0733679406643522 4551 16268368
SGTC_1737 st035557 69.7 µM -1.45149616011493 0.0546821300833341 no 3175 0.0733208753545996 4304 5716916
SGTC_2007 4011539 71.82 µM -1.45196686784122 0.0546231705406876 no 3176 0.0732554089800332 4422 45595301
SGTC_1269 0831-0796 3.05 µM -1.45491577096523 0.0542549422360809 no 3177 0.0728462905830879 4492 927758
SGTC_2017 5132927 60.65 µM -1.45700292485018 0.0539955092837585 no 3178 0.0725577864251709 4458 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.45884047161857 0.053767916239712 no 3179 0.0723045102565413 4477 61125 An anti-inflammatory.
SGTC_2966 9084041 48.03 µM -1.45970799838614 0.0536607313012151 no 3180 0.072185171371054 4386 17741380
SGTC_638 3970-0837 4.09 µM -1.462757666514 0.0532852804583086 no 3181 0.0717668502940221 4456 4118451 YLR208W SEC13
SGTC_2755 lomerizine 42.69 µM -1.46575774350165 0.0529179695727039 no 3182 0.0713571483980016 4410 3949 A calcium channel blocker.
SGTC_3196 9111891 49.47 µM -1.46741042540236 0.0527164849661541 no 3183 0.0711322200718247 4460 18891510
SGTC_2762 leflunomide 42.06 µM -1.47252801830132 0.0520964388655119 no 3184 0.0704391733285838 4453 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_681 1642-0006 26.6 µM -1.47381736086689 0.0519411396817833 no 3185 0.070265386332385 4486 4446530
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.47399606451747 0.0519196441775018 no 3186 0.0702413253913929 4449 364106
SGTC_889 0919-1524 82.7 µM -1.47614883484227 0.0516612516790391 no 3187 0.0699519707285445 4492 3905452
SGTC_3046 9092212 49.47 µM -1.47686042037169 0.0515760667293247 no 3188 0.0698565282111345 4546 25236637
SGTC_841 0251-0215 91.2 µM -1.4779435332806 0.0514466201070952 no 3189 0.0697114464111324 4521 3888614
SGTC_3006 9075424 71.4286 µM -1.47895773997596 0.0513256430853505 no 3190 0.0695758049105604 4442 7465181
SGTC_2234 tolnaftate 200 µM -1.48069216620099 0.0511192810546924 no 3191 0.0693443112239022 4594 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_423 5-fluorouracil 457 µM -1.48398912075755 0.0507288302509887 no 3192 0.0689059034021177 4430 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1362 1611-0397 101 µM -1.48663014295359 0.0504177763285349 no 3193 0.0685562610493667 4467 27816
SGTC_1722 st034304 3.6505 µM -1.48675729567126 0.0504028389855672 no 3194 0.0685394620180433 4435 4036148 YLR033W RSC58
SGTC_2326 6164455 177.58 µM -1.48684569605463 0.0503924561748865 no 3195 0.068527784698854 4425 2888790
SGTC_1958 st076513 41.9 µM -1.48775823597013 0.0502853760202894 no 3196 0.0684073316829585 4425 732122 YGL099W LSG1
SGTC_1466 k213-0079 57.5 µM -1.48884311966859 0.0501583085749887 no 3197 0.0682643423343186 4470 3657981
SGTC_2314 7727897 200 µM -1.49030498900825 0.0499874915248766 no 3198 0.0680720306505063 4465 900724
SGTC_2984 9022109 38.96 µM -1.49237011515933 0.0497469757960022 no 3199 0.0678010724869806 4504 6459207
SGTC_341 1486-1430 230 µM -1.4955548444817 0.0493778757396077 no 3200 0.0673848488847909 4449 2054753 YPL210C SRP72
SGTC_744 1594-0068 283 µM -1.49622763337012 0.0493001820501209 no 3201 0.0672971729214247 4481 668392
SGTC_445 e6 berbamine 66 µM -1.49725667777777 0.049181536813242 no 3202 0.067163241368228 4499 6610268 A calcium/calmodulin antagonist.
SGTC_1341 1486-1360 280 µM -1.49870884950251 0.0490144945482154 no 3203 0.0669745899711328 4479 3976547
SGTC_2070 5230947 200 µM -1.49894890630763 0.0489869246933462 no 3204 0.0669434437461201 4577 2835538
SGTC_3241 9133421 49.47 µM -1.49904639083498 0.0489757324048584 no 3205 0.0669307987931153 4583 17018221
SGTC_624 k048-0052 28 µM -1.4992368496511 0.0489538715474598 no 3206 0.066906099252305 4492 6835531
SGTC_2939 9044578 71.43 µM -1.50063207312871 0.0487939654885685 no 3207 0.0667253754784349 4424 2653634
SGTC_2792 7535235 81.82 µM -1.50180630821499 0.0486597105731866 no 3208 0.0665735693503218 4462 1281891
SGTC_1159 4092-0538 61.2 µM -1.50333131434426 0.048485791597044 no 3209 0.0663768144525081 4518 717301
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.50639080891278 0.0481383713788728 no 3210 0.0659834393719257 4479 5379071
SGTC_860 0443-0016 25.1 µM -1.5093608430802 0.0478030180610513 no 3211 0.0656032969726219 4522 5337942
SGTC_2992 9074591 71.4286 µM -1.51042206666788 0.0476836474607359 no 3212 0.065467880735428 4438 17741321
SGTC_390 dec-rvkr-cmk 16.7 µM -1.51101828395722 0.0476166874029487 no 3213 0.0653918962681267 4517 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3331 9141060 1.957 µM -1.5182753108332 0.0468076868570668 no 3214 0.0644725044824328 4445 4906567 YPR165W RHO1
SGTC_162 k030-0015 37.8 µM -1.51968877673221 0.0466514064402361 no 3215 0.0642946068292894 4557 1809920 YMR134W ERG29
SGTC_1850 st056238 17 µM -1.52848938533963 0.0456877601639705 no 3216 0.0631955384958657 4514 5393177
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.52924646383631 0.0456056148136207 no 3217 0.0631016779734923 4539 5106787 A p450 inhibitor.
SGTC_2222 6885208 172.143 µM -1.53269056786835 0.0452334165692292 no 3218 0.0626760571328234 4529 609514
SGTC_308 4092-1169 104 µM -1.54160483451774 0.0442814083259277 no 3219 0.0615848250172863 4483 2268590 YDL196W YDL196W
SGTC_3210 9128157 49.47 µM -1.55350764687431 0.0430354846375261 no 3220 0.0601509519139198 4466 17590849
SGTC_1357 1503-1303 39.5 µM -1.55382345530025 0.0430028171841949 no 3221 0.0601132670346711 4500 292895
SGTC_1205 4161-2785 76 µM -1.56283304063323 0.0420792677450849 no 3222 0.0590459352432952 4515 3498106
SGTC_244 nsc-207895 1.295 µM -1.56795434693597 0.041561493590825 no 3223 0.0584458935351584 4313 42640
SGTC_197 4544-0043 41.561 µM -1.56797222587417 0.0415596950777718 no 3224 0.058443807155347 4553 896523
SGTC_1300 1094-0077 113 µM -1.5685882731288 0.0414977629575308 no 3225 0.0583719533414832 4508 5532636
SGTC_2338 7999974 200 µM -1.57663329637617 0.0406958297478204 no 3226 0.0574399633756778 4516 315925
SGTC_1682 st012968 530 nM -1.5799125480497 0.0403725805445725 no 3227 0.0570634475976899 4516 24207270
SGTC_1964 st076914 61 µM -1.58048372301025 0.0403164912832308 no 3228 0.0569980657941192 4564 24208661
SGTC_1465 k213-0056 144 µM -1.5875188061398 0.0396308241281484 no 3229 0.0561975955487419 4458 24048857 YMR208W ERG12
SGTC_78 0336-0123 156.75 µM -1.58938941010607 0.0394501124134887 no 3230 0.0559862519801568 4401 6765896
SGTC_818 4072-2707 53.5 µM -1.59313193947065 0.0390905735665802 no 3231 0.0555652977731177 4473 882871
SGTC_518 1021-0119 62.6 µM -1.59693716718862 0.0387277508797685 no 3232 0.055139856933598 4521 1097762
SGTC_2203 7227154 166.4 µM -1.59927835333865 0.0385058887767241 no 3233 0.0548793835721574 4566 896304
SGTC_2283 7944793 200 µM -1.61048998510453 0.0374577360949565 no 3234 0.053645465031539 4540 2970533
SGTC_1963 st076565 50.3 µM -1.63161571237152 0.035546081534185 no 3235 0.0513802330669848 4574 4914280
SGTC_348 k064-0012 10.7 µM -1.63634488375406 0.0351292857176289 no 3236 0.0508837136956799 4519 5066323
SGTC_2168 5727979 200 µM -1.6386185912651 0.0349303292534314 no 3237 0.0506463589945474 4479 695210
SGTC_2087 5276107 200 µM -1.63929028263025 0.0348717314658417 no 3238 0.0505764094190618 4557 144405
SGTC_2429 5902844 64.44 µM -1.64735838054282 0.034174163320066 no 3239 0.0497422023260222 4551 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_5 0352-0601 109.883 µM -1.65007848755433 0.0339415843851338 no 3240 0.049463442029547 4478 762456
SGTC_2427 5545055 42.75 µM -1.65404389258723 0.0336048617389046 no 3241 0.0490592974060523 4503 5372858
SGTC_1478 0453-0656 35.7 µM -1.65740727321557 0.0333214194268277 no 3242 0.0487185809680628 4610 5258496
SGTC_1017 4239-0030 168 µM -1.65749219120705 0.0333142886898046 no 3243 0.0487100031665685 4586 1149593
SGTC_3191 9110352 49.47 µM -1.65808860915655 0.0332642416589331 no 3244 0.0486497913473185 4523 17122424
SGTC_1327 1436-0082 2.18 µM -1.66679985406734 0.0325402891224003 no 3245 0.047777104641714 4590 15992205
SGTC_755 1995-0008 37.3 µM -1.66762548811134 0.0324723538348602 no 3246 0.0476950476438773 4559 689533
SGTC_1902 st060212 70.5 µM -1.67985013763866 0.0314800983078411 no 3247 0.04649323864968 4571 688944
SGTC_2214 7179297 48.276 µM -1.68176852920285 0.0313266847129965 no 3248 0.0463068667522633 4645 769744
SGTC_2072 5231554 129 µM -1.68209434499123 0.0313006907732337 no 3249 0.046275273392935 4649 789545
SGTC_126 0417-1624 672.48 µM -1.68399360674085 0.0311495204092573 no 3250 0.0460914521523701 4621 41912 YDL195W SEC31
SGTC_2416 tofa 880 nM -1.69369505992411 0.0303867331296061 no 3251 0.0451616218442081 4534 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1651 st011928 86.1 µM -1.70677761647432 0.0293826722476925 no 3252 0.0439316971667899 4596 720198
SGTC_2106 5357045 167.29 µM -1.70713650096316 0.0293555215235659 no 3253 0.0438983420610752 4608 668842
SGTC_904 1141-0088 396 µM -1.71170995124488 0.0290113465312813 no 3254 0.0434750669099383 4613 1378119
SGTC_2618 avocadyne 43.43 µM -1.71273348596314 0.0289347813917858 no 3255 0.0433807908515272 4539 3015189
SGTC_1782 st039423 80.636 µM -1.7179967624594 0.0285437115769955 no 3256 0.0428986029023681 4608 2068169
SGTC_647 0140-0236 81 µM -1.71897194489877 0.0284717389288381 no 3257 0.0428097402560288 4610 990837
SGTC_329 k048-0121 21.3 µM -1.724856534927 0.0280406285828313 no 3258 0.0422766651476186 4609 6832902
SGTC_2787 5284540 71.43 µM -1.73073527523664 0.027615388457132 no 3259 0.0417494953118501 4599 736958
SGTC_1197 1601-0112 267 µM -1.73300378279934 0.0274527390880398 no 3260 0.0415474982209895 4571 7350313
SGTC_2408 sulbentine 18.36 µM -1.73602088878457 0.0272376544535418 no 3261 0.0412800705676401 4464 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2957 9076800 11.52 µM -1.75734574787191 0.0257571849713312 no 3262 0.0394294472627185 4597 16459615
SGTC_2224 6650123 117.647 µM -1.75902323752807 0.0256436395691523 no 3263 0.0392867808596296 4660 2908370
SGTC_2113 5491891 107.031 µM -1.76521743446343 0.0252279928029412 no 3264 0.0387636147894883 4600 789979
SGTC_1594 piperine 70.1 µM -1.76559401870694 0.0252029061161279 no 3265 0.0387319921100747 4595 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2956 9076196 2.52 µM -1.76723977589337 0.0250935168734442 no 3266 0.0385940404642005 4602 16423868
SGTC_1857 st056007 79.3 µM -1.77336572216424 0.024689832539419 no 3267 0.0380840625554469 4610 619834
SGTC_1182 1222-0449 220 µM -1.77653347876309 0.0244832315851404 no 3268 0.0378225144457083 4625 658318
SGTC_1354 1498-1681 81 µM -1.78050003015302 0.0242265812296395 no 3269 0.0374970821983451 4643 5754243
SGTC_170 4197-0004 226 µM -1.78071555654878 0.0242127008512322 no 3270 0.0374794652255218 4621 218692
SGTC_2868 9035608 32.47 µM -1.79065219764129 0.0235799734776999 no 3271 0.0366745625736112 4611 6462614
SGTC_1986 st071812 45 µM -1.79322385288008 0.0234185045095322 no 3272 0.0364685687542502 4582 11838594
SGTC_1442 4112-3290 3 µM -1.79538792815217 0.0232833484665715 no 3273 0.0362959572362651 4643 704353
SGTC_719 2810-4230 27.3 µM -1.80558265018814 0.0226554430547725 no 3274 0.035491777373335 4656 721079
SGTC_3335 9143315 29.6265 µM -1.80922375158406 0.022434670117567 no 3275 0.035208124546458 4646 4899691
SGTC_909 3448-9333 149 µM -1.81152630338273 0.0222959968403422 no 3276 0.0350297106049755 4563 3344074
SGTC_295 k015-0027 31 µM -1.8240440811702 0.0215546930155129 no 3277 0.0340727041420001 4679 3887424
SGTC_758 0868-0029 16 µM -1.83121579000597 0.0211394472170758 no 3278 0.033534170414017 4580 762687
SGTC_1763 st044482 94.5 µM -1.84542537391129 0.0203366705650776 no 3279 0.0324878424439433 4625 88505
SGTC_1771 st048882 4.1505 µM -1.85287685906741 0.0199261256214768 no 3280 0.0319500053152611 4655 4580403
SGTC_849 0386-0493 241 µM -1.85458701575658 0.0198329019007212 no 3281 0.0318276118485408 4658 726119
SGTC_94 0334-0113 514.748 µM -1.85491061331751 0.0198153037254429 no 3282 0.0318044960675795 4649 6795178
SGTC_3062 9077494 49.47 µM -1.86053543953503 0.0195115203010094 no 3283 0.0314049046342062 4580 16459633
SGTC_2012 4023501 200 µM -1.874378492744 0.018780693853221 no 3284 0.0304391378512521 4629 3477460
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.87472450428988 0.0187627291256864 no 3285 0.0304153169842069 4640 97141
SGTC_157 1348-1695 65.819 µM -1.89195748684953 0.0178863178715219 no 3286 0.0292483226856682 4572 5380510
SGTC_1290 0986-0249 10.2 µM -1.91228402574673 0.016897684751508 no 3287 0.0279198868092039 4556 53329
SGTC_272 doxorubicin 8.13 µM -1.91671713276538 0.0166883882773548 no 3288 0.0276369387367866 4684 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1036 k216-0215 33.5 µM -1.91680939111533 0.016684056229248 no 3289 0.0276310757242299 4618 622330
SGTC_2785 7756463 72.73 µM -1.91703128531126 0.0166736409892209 no 3290 0.0276169786065849 4641 2201551
SGTC_560 2332-1943 155 µM -1.91809385309049 0.0166238433948194 no 3291 0.027549555878008 4663 21177716
SGTC_2790 5423970 71.43 µM -1.93783625359748 0.0157214995781123 no 3292 0.0263216015953559 4643 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2419 paclitaxel 166.5 µM -1.93821150972709 0.0157047632983928 no 3293 0.0262987115525251 4608 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_752 1896-0090 130 µM -1.93948380307415 0.0156481332128786 no 3294 0.0262212274434151 4691 772567
SGTC_2005 4024620 188 µM -1.94546199795353 0.0153843822425342 no 3295 0.0258596996025298 4624 236743
SGTC_2284 7945075 39.21 µM -1.95014400090538 0.0151804916949967 no 3296 0.0255794790348031 4626 1245402
SGTC_1274 0865-0114 173 µM -1.97221024457925 0.0142505212225637 no 3297 0.024292805334703 4672 870624
SGTC_1034 k072-0165 12.7 µM -1.9848384639499 0.01374071657378 no 3298 0.0235812232752704 4679 5835461
SGTC_2018 5133068 143 µM -2.00203947999934 0.0130716658737254 no 3299 0.0226402427971743 4652 785362
SGTC_614 0462-0418 107 µM -2.02024994249123 0.0123942210651054 no 3300 0.0216787341280529 4499 5188303
SGTC_1213 1315-0166 115 µM -2.02614773701306 0.0121814376150558 no 3301 0.0213748237260796 4677 768401
SGTC_1431 4049-0260 9.09 µM -2.03728135388626 0.0117883725612947 no 3302 0.0208109276443676 4723 3854841
SGTC_2961 9083290 32.55 µM -2.03839504298153 0.0117496668127923 no 3303 0.0207552208199081 4665 17741490
SGTC_1578 josamycin 24.2 µM -2.0437469996615 0.0115651967960331 no 3304 0.0204892737520783 4692 5282165 A P450 substrate.
SGTC_2110 5483698 200 µM -2.05628802237983 0.0111427586126692 no 3305 0.0198773810625248 4687 2848765 YHR062C RPP1
SGTC_2095 5432005 200 µM -2.05727708802889 0.0111100205997156 no 3306 0.019829789995912 4712 783734
SGTC_302 1094-0063 18.9 µM -2.06963695505127 0.0107079106710684 no 3307 0.0192431773372631 4711 5440289
SGTC_1376 2910-0861 41.3 µM -2.07791691852591 0.0104456767989626 no 3308 0.0188585059849714 4662 1112859
SGTC_301 4119-0100 24.5 µM -2.08061874153175 0.0103613274347886 no 3309 0.0187344085361405 4711 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3206 9114350 49.47 µM -2.08844198305796 0.0101204305822348 no 3310 0.0183789918563656 4593 17087243
SGTC_1957 st077035 62.4 µM -2.09179970016055 0.010018546217208 no 3311 0.018228218603549 4709 705593
SGTC_2990 9074105 71.4286 µM -2.10091985321394 0.00974631559140907 no 3312 0.0178240011678703 4647 6502001
SGTC_1342 1486-1464 234 µM -2.10141998918652 0.00973157557746398 no 3313 0.0178020573821201 4728 3253938
SGTC_2694 st077685 81.9 µM -2.11703809382022 0.00928097466531587 no 3314 0.0171283074526183 4635 2838096
SGTC_300 r073-0011 5.04 µM -2.13032109475418 0.00891221928036711 no 3315 0.0165725565747598 4709 2735780
SGTC_1904 st060225 78 µM -2.15616442763142 0.00823140158772791 no 3316 0.0155354140630632 4700 66595
SGTC_1425 4048-4433 7.33 µM -2.16641186334314 0.00797435946034598 no 3317 0.0151398641093648 4756 23734946
SGTC_2783 7738165 71.43 µM -2.18175784805777 0.00760262551645558 no 3318 0.0145637045181381 4697 17201110
SGTC_521 r062-0005 13.8 µM -2.18762448035161 0.00746459843762454 no 3319 0.0143484835693635 4670 2832033
SGTC_1287 0971-0001 34.6 µM -2.18909398950067 0.00743037226977794 no 3320 0.0142950046551706 4729 4665869
SGTC_2805 7950783 58.44 µM -2.21349310857956 0.0068819639232169 no 3321 0.0134318339149545 4699 1178958 YDL195W SEC31
SGTC_1439 4092-1168 46 µM -2.22324043620878 0.00667307154676895 no 3322 0.0130997957694991 4741 2886240
SGTC_550 4123-0385 25.7 µM -2.22374511124744 0.00666241023591067 no 3323 0.0130827991208626 4734 5731123
SGTC_1202 1988-0068 29.6 µM -2.24345012872577 0.00625773740902941 no 3324 0.0124339012028367 4714 2850480
SGTC_765 1319-0117 244 µM -2.30886383815112 0.00506599551342097 no 3325 0.0104755691035794 4731 3487746 YGL099W LSG1
SGTC_3051 9093778 49.47 µM -2.32223506053929 0.00484888783603407 no 3326 0.0101101410459842 4783 17217378
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.34631208432541 0.00447877685420537 no 3327 0.00948011216647108 4744 688803
SGTC_2334 9017922 200 µM -2.35548411112961 0.00434455962840277 no 3328 0.00924929406347991 4724 3163164
SGTC_888 0916-0002 6.97 µM -2.35599507664108 0.00433718932740755 no 3329 0.00923658126684906 4743 2802138 YIL048W NEO1
SGTC_1199 1638-0010 4.46 µM -2.36000326683125 0.00427976071108418 no 3330 0.00913738706468261 4746 3111136
SGTC_2813 7971799 71.43 µM -2.37682533554457 0.00404608158827277 no 3331 0.00873117734367112 4719 2234054
SGTC_2001 4023502 57.655 µM -2.42835982675853 0.00339963769652299 no 3332 0.0075836434423778 4739 108941 YCR052W RSC6
SGTC_981 1488-1094 54.9 µM -2.44113262345343 0.00325450438431739 no 3333 0.00732063837358631 4737 3449522
SGTC_2333 9017922 200 µM -2.45465231545646 0.00310697798704899 no 3334 0.0070510454088149 4729 3163164
SGTC_2614 arthonioic acid 13.39 µM -2.45487929843514 0.00310455339615472 no 3335 0.00704659498680649 4669 6710684
SGTC_1822 st052468 42 µM -2.46176216197839 0.00303183619981887 no 3336 0.00691281573424829 4777 2873678
SGTC_1905 st060207 84.5 µM -2.51715588025607 0.00250022961985929 no 3337 0.00591532372499519 4755 1948547
SGTC_613 3914-0030 117 µM -2.54628583621825 0.00225589653010427 no 3338 0.00544379981970333 4637 1145395
SGTC_3057 9095946 49.47 µM -2.5562401020115 0.00217749814584562 no 3339 0.00529050403270169 4784 24540043
SGTC_1459 k035-0031 35.7 µM -2.57245954265247 0.00205503330799904 no 3340 0.0050489378655517 4664 3877128 YMR208W ERG12
SGTC_2332 7982454 138.89 µM -2.63373604665743 0.00164672988791062 no 3341 0.0042225555779542 4728 2981748
SGTC_1777 st045864 34.765 µM -2.69388092476128 0.00131922505994982 no 3342 0.00353126955638783 4778 4691462
SGTC_1774 st048371 48.465 µM -2.71531852510941 0.00121770271266345 no 3343 0.00331060267694122 4774 4242727
SGTC_1775 st081588 35.1725 µM -2.71845895645959 0.00120344618304486 no 3344 0.00327933961358077 4767 1426443 YGL099W LSG1
SGTC_531 3788-1495 174 µM -2.7675242832834 0.000999664409750965 yes 3345 0.00282419186595815 4767 2896655
SGTC_1504 k297-0033 30 µM -2.93392923550382 0.00052153733480391 yes 3346 0.00167350253786111 4764 4388117
SGTC_2016 5121758 140 µM -3.01514664292832 0.000375088386785567 yes 3347 0.00128427518358422 4753 2795203
SGTC_885 0865-0106 16.8 µM -3.03539617675201 0.0003450687246824 yes 3348 0.00120109956639741 4783 2793380
SGTC_2287 7945887 168.79 µM -3.30313900401601 0.000109314646716759 yes 3349 0.000478044909489067 4796 1245853
SGTC_231 b-estradiol 524 µM -3.37396715451489 7.94889391371422e-05 yes 3350 0.000370466039656685 4807 450 A steroid.
SGTC_1107 amlodipine 47 µM -3.41951693150268 6.45536403566471e-05 yes 3351 0.000313662141940774 4545 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2280 7785178 200 µM -3.77474902871743 1.1676701622274e-05 yes 3352 8.00844170713286e-05 4801 2954328
SGTC_750 4073-0104 132 µM -4.59103998506387 1.27560718493102e-07 yes 3353 2.20521411841707e-06 4771 22330957