SGTCid condition conc unit PMP2|YEL017C-A.score PMP2|YEL017C-A.strain.pval PMP2|YEL017C-A.strain.significant PMP2|YEL017C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_145 3737-0113 38.366 µM 7.45455026094588 1.1829543058584e-12 yes 1 4.50874480892206e-14 12 6849351 SGTC_17 0960-0276 49.807 µM 5.94275205837762 1.14846112507089e-08 yes 2 1.40138103307676e-09 5 6821114 SGTC_425 3825-7017 13.1 µM 5.72616475512717 3.63962748134642e-08 yes 3 5.13632308526793e-09 7 3397440 SGTC_9 0092-0002 10.449 µM 5.33904844567746 2.5868468186389e-07 yes 4 4.67178384520206e-08 9 759368 SGTC_146 3448-8650 53.125 µM 5.30617252150946 3.03759213020697e-07 yes 5 5.59755036198214e-08 67 2891488 YIL048W NEO1 SGTC_1493 4348-0038 111 µM 5.03152914632571 1.12095383633214e-06 yes 6 2.43291558206865e-07 7 800424 SGTC_431 k089-0097 107 µM 5.01106069989954 1.23233125847343e-06 yes 7 2.70654177204553e-07 12 5499420 SGTC_2411 st077133 39.94 µM 4.87913072574328 2.24992383935682e-06 yes 8 5.32772120772373e-07 14 1403142 YNL221C POP1 SGTC_126 0417-1624 672.48 µM 4.76510355329716 3.74057097839703e-06 yes 9 9.43783417264883e-07 12 41912 YDL195W SEC31 SGTC_144 4161-2749 112.381 µM 4.54239722122289 9.77838284482368e-06 yes 10 2.78090574236902e-06 18 797501 YMR168C CEP3 SGTC_143 4032-1194 15.74 µM 4.26438026540666 3.05913062208156e-05 yes 11 1.00228901188763e-05 52 1806963 SGTC_427 1354-0053 47.3 µM 4.22053709799559 3.6401520540916e-05 yes 12 1.21860471611252e-05 14 6813657 SGTC_2371 9071574 200 µM 4.20720238616074 3.8366244266791e-05 yes 13 1.29275786417567e-05 10 45596039 SGTC_115 0527-0192 112.043 µM 4.18068153102313 4.25755994722258e-05 yes 14 1.45318339787467e-05 58 4233931 SGTC_2376 9072922 81.32 µM 4.17469128076392 4.35849937330821e-05 yes 15 1.49195208425817e-05 20 17087968 SGTC_2036 5160441 105 µM 3.99674647679707 8.62265701619209e-05 yes 16 3.21095064296862e-05 77 134534 YIL048W NEO1 SGTC_2378 9074213 121.43 µM 3.97154898003514 9.47683776764637e-05 yes 17 3.57034075249735e-05 19 657714 SGTC_2379 9035213 200 µM 3.95547624251802 0.000100625804600195 yes 18 3.81911694325374e-05 20 646551 SGTC_131 0141-0277 33.849 µM 3.91691939982685 0.000116093201499031 yes 19 4.48438591197504e-05 41 1547771 SGTC_125 0133-0007 11.75 µM 3.88056507093134 0.000132696883895007 yes 20 5.21070287842989e-05 9 26541 SGTC_1129 3453-1384 223 µM 3.76284712279344 0.000203022060591133 yes 21 8.39949503697817e-05 45 1084452 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 3.70236206357381 0.000251464889604744 yes 22 0.000106800748146751 36 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1973 st070275 50.2 µM 3.68220377385708 0.000269870422514186 yes 23 0.000115613234816652 17 17118334 SGTC_1526 st051518 75 µM 3.65581854514387 0.000295860590752235 yes 24 0.000128181325026597 28 673993 SGTC_2079 5212404 121 µM 3.63814003694311 0.000314558152596914 yes 25 0.000137307052475024 17 758462 SGTC_181 1447-1644 8.07 µM 3.60741377409945 0.000349693886815185 yes 26 0.000154632131891972 43 534600 SGTC_1953 st076800 12.1 µM 3.59524558301692 0.000364590516005869 yes 27 0.000162042855745315 57 297591 SGTC_2080 5212524 12.4 µM 3.54199879339414 0.000436973614405893 yes 28 0.000198553645336892 25 260183 SGTC_1114 scopoletin 1.73284 µM 3.48266225235471 0.000533204225227843 yes 29 0.000248227137336994 29 5280460 A coumarin with genotoxic properties. SGTC_2568 diosmetin 100 µM 3.48139608230464 0.000535456540036921 yes 30 0.000249403645142028 36 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_292 k038-0015 474 µM 3.42292566719188 0.000649578997708669 yes 31 0.00030975507950755 12 46368540 SGTC_1651 st011928 86.1 µM 3.33444378116792 0.000865500258778307 yes 32 0.000427350878894874 29 720198 SGTC_1956 st077085 54 µM 3.32634428337368 0.000888250636766278 yes 33 0.000439965848640035 41 24208685 SGTC_1951 sophoraflavanone G 9.2 µM 3.32027621128885 0.000905653815931241 yes 34 0.000449642129289325 56 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_78 0336-0123 156.75 µM 3.31229266214299 0.000929027967864619 yes 35 0.000462673442005843 36 6765896 SGTC_184 1494-0393 24.714 µM 3.28994909329384 0.000997422607467549 yes 36 0.00050102754921195 95 3090647 SGTC_113 0099-0221 2.5 µM 3.28345648326456 0.00101814623671581 no 37 0.000512712373904554 56 89219 SGTC_1896 st058441 89 µM 3.28123100216627 0.00102534013269112 no 38 0.000516775292804888 34 688759 SGTC_2287 7945887 168.79 µM 3.22566456629486 0.00122078835171244 no 39 0.000628402795408539 23 1245853 SGTC_128 0906-2981 13.371 µM 3.20793227018732 0.00128999503232938 no 40 0.000668464897169533 29 6740226 SGTC_71 0417-1750 47.813 µM 3.20148426277955 0.00131603744564399 no 41 0.000683607716112448 88 6811472 SGTC_471 1-acyl-paf 4 µM 3.13637873131286 0.00160723581134594 no 42 0.000855240795901334 56 16759367 SGTC_314 1671-0008 2.74 µM 3.12330462456381 0.00167236089030896 no 43 0.000894162755915215 97 3913060 SGTC_430 0958-0115 16.4 µM 3.11714370411545 0.001703875183622 no 44 0.000913062669194816 74 6833180 SGTC_2528 xanthyletin 44.79 µM 3.11146668027747 0.00173339187648624 no 45 0.000930802405906567 48 65188 An natural product with antifungal activity of unknown mechanism. SGTC_452 diindolylmethane 8 µM 3.08294438988159 0.00188885215858141 no 46 0.00102481726238312 35 3071 Inhibits expression of several cancer promoting factors. SGTC_983 1491-0821 12.2 µM 3.07145128354671 0.00195499926784644 no 47 0.00106510461145897 39 46495113 SGTC_1926 methyl fluorone black 53.6 µM 3.05886651935953 0.00202983689769356 no 48 0.00111088059102616 103 72721 Reacts with homocysteine. SGTC_1118 chelidonine 707.474 nM 3.03128371536192 0.00220303569843465 no 49 0.00121758156247578 56 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1601 4'-hydroxyflavanone 55.5 µM 3.02618939529913 0.00223645228356728 no 50 0.00123828561031411 68 165506 SGTC_1228 0124-0032 52.5 µM 3.02426449990512 0.00224919787353272 no 51 0.00124619215286364 63 X1228 SGTC_948 3448-0295 75.3 µM 3.02125577660168 0.00226925183609785 no 52 0.00125864309414954 83 678569 SGTC_464 bw-b 70c 158 µM 2.93873690209071 0.00288641859348849 no 53 0.00164776346994023 77 5353454 SGTC_2399 5884133 200 µM 2.9111194797366 0.00312453966332948 no 54 0.00180068137158513 137 722445 SGTC_1711 st032263 62.8 µM 2.90843339076864 0.00314861812387044 no 55 0.00181622274560548 55 3958979 SGTC_2123 5259487 200 µM 2.89859324244366 0.00323825967044076 no 56 0.00187420417162892 63 2173474 SGTC_2485 5633444 17.78 µM 2.886430078789 0.00335223255687719 no 57 0.00194819656629599 99 5724239 SGTC_106 0092-0003 11.579 µM 2.8666948372148 0.00354484596703801 no 58 0.00207391376854189 45 1072148 SGTC_318 1488-0629 67.2 µM 2.86043065712658 0.00360802872673575 no 59 0.00211533031285923 69 3662576 SGTC_3161 9100388 49.47 µM 2.85224556796888 0.00369210896867043 no 60 0.00217057748333266 40 25236368 SGTC_2453 5731132 22.18 µM 2.84800447208199 0.00373636274641128 no 61 0.0021997153173894 89 1362040 SGTC_2033 5192550 145 µM 2.81656428453365 0.0040795366179669 no 62 0.00242701639103193 59 182073 SGTC_2425 5628681 7.85 µM 2.81231771401389 0.00412798905886506 no 63 0.00245929467230516 91 5714958 SGTC_2929 9013348 24.6 µM 2.76356537642174 0.00472227347170505 no 64 0.00285868188318741 86 2995952 SGTC_259 usnic acid 108.925 µM 2.7526743684545 0.00486503290567718 no 65 0.00295553293753556 78 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1790 st045711 43.5 µM 2.74637935710998 0.00494929091095332 no 66 0.00301285216137589 64 585119 SGTC_1218 1348-1416 30.7 µM 2.74392950302081 0.00498243177091265 no 67 0.00303542868130734 78 6787668 SGTC_2416 tofa 880 nM 2.73641839864613 0.00508527512777856 no 68 0.00310559987732892 123 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2414 st077232 92.9 µM 2.72872793982712 0.00519252826118291 no 69 0.00317895666699897 91 729801 SGTC_995 3931-2021 34.6 µM 2.71874207510335 0.0053347952215687 no 70 0.00327653424999371 94 730143 SGTC_1319 1306-0155 43.7 µM 2.71311549505489 0.00541647377366138 no 71 0.00333269355475451 114 3122360 SGTC_3258 9138477 49.47 µM 2.70771742799797 0.00549587795781663 no 72 0.00338738387268542 65 4970355 SGTC_36 0335-0881 14.2 µM 2.6906837430743 0.00575326289875975 no 73 0.0035652878022343 217 23828853 SGTC_403 arphamenine a 50 µM 2.66257339196845 0.0062014664769158 no 74 0.00387728285111637 90 5487158 An arginine aminopeptidase inhibitor. SGTC_662 k832-1615 104 µM 2.65715337493764 0.00629135787691521 no 75 0.0039401791002613 96 5878478 SGTC_1470 k295-0292 231 µM 2.63686780927439 0.00663811771136067 no 76 0.00418377160737378 76 5045612 SGTC_440 fluspirilene 35.1 µM 2.6350538512191 0.0066699333034872 no 77 0.00420619677853794 100 3396 An atypical antipsychotic. SGTC_219 mitoxanthrone 164.414 µM 2.63203001441262 0.006723269029589 no 78 0.00424381821256612 122 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1634 st006576 41 µM 2.62423302433747 0.00686253830416056 no 79 0.00434221733035108 101 3915356 SGTC_2280 7785178 200 µM 2.59204786760885 0.00746475713825372 no 80 0.00477032479232597 74 2954328 SGTC_1919 st067113 52.3 µM 2.5876082600216 0.00755137989790639 no 81 0.00483224104595642 116 1268243 SGTC_129 0088-0017 176.636 µM 2.58491624070131 0.00760433492644344 no 82 0.00487013281217805 153 182446 SGTC_2442 5158906 48.48 µM 2.58346223933378 0.00763307254025811 no 83 0.00489070869290791 98 1893835 SGTC_2445 5742597 35.57 µM 2.5818712951705 0.00766462627066277 no 84 0.00491331120787489 108 1774255 SGTC_965 1291-5240 308 µM 2.57632865596753 0.00777545396814622 no 85 0.0049927841343329 107 2834598 SGTC_2055 5235184 200 µM 2.57248805337921 0.00785307340713889 no 86 0.00504852203143673 120 2836034 SGTC_2282 7944268 200 µM 2.56928310908376 0.00791836694781132 no 87 0.00509545815106431 138 2970414 SGTC_73 0327-0325 16.231 µM 2.56268780820713 0.00805423524587793 no 88 0.00519326979091579 180 53298 SGTC_2066 5222451 176 µM 2.55360489824086 0.00824470287357448 no 89 0.00533070794716768 141 2281147 SGTC_1292 0kpi-0043 232 µM 2.52116517795192 0.00895763824962703 no 90 0.00584834657418356 102 3333905 SGTC_3349 9149703 23.001 µM 2.50452778725225 0.00934381328274625 no 91 0.00613074867056784 94 4910494 SGTC_725 1497-0963 19 µM 2.5038285196864 0.00936035835702488 no 92 0.0061428781755748 97 3549977 SGTC_894 0960-0238 55.9 µM 2.4613436409156 0.0104148737452563 no 93 0.00692088584639001 82 6741907 YDL195W SEC31 SGTC_400 oxethazaine 37.5 µM 2.45373463005463 0.0106142939700832 no 94 0.00706906362892977 110 4621 A local anesthetic. SGTC_1748 st037455 53.6035 µM 2.45276198656696 0.0106400236627814 no 95 0.00708820526082293 152 580690 SGTC_52 0329-0193 875 nM 2.44809535392992 0.0107642287715257 no 96 0.00718068214400906 128 3739292 SGTC_1660 st012960 28.1 µM 2.429910955488 0.0112603373746679 no 97 0.00755126636314571 145 24207266 SGTC_2561 acetosyringone 100 µM 2.4268247934498 0.0113464781968992 no 98 0.00761580484619705 151 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3051 9093778 49.47 µM 2.42244963106548 0.0114695786288238 no 99 0.00770813137015813 55 17217378 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 2.40749479570489 0.0118991516275607 no 100 0.00803119556871046 42 1241132 A phosphatase inhibitor. SGTC_2403 6032726 181.2 µM 2.40699388326089 0.0119137785762305 no 101 0.00804221962902304 147 2881040 SGTC_964 1287-0107 19.4 µM 2.40378260193996 0.0120079209509194 no 102 0.00811320987778699 161 51516812 YPR165W RHO1 SGTC_2117 5521686 200 µM 2.3926551056352 0.0123391440160927 no 103 0.0083634781956469 135 803312 SGTC_1777 st045864 34.765 µM 2.39220299090892 0.0123527674455587 no 104 0.00837378845134139 106 4691462 SGTC_3280 9140961 49.47 µM 2.39169306109649 0.0123681486321121 no 105 0.00838543054078861 98 4901226 SGTC_456 gingerol 170 µM 2.38300430614981 0.0126327914499559 no 106 0.0085859967302712 134 442793 A herb. SGTC_67 0335-0847 266 µM 2.37867688380337 0.0127664150423272 no 107 0.00868744930880674 290 4552207 YOR254C SEC63 SGTC_1773 st048542 73.5835 µM 2.37783133682288 0.0127926664491689 no 108 0.00870739471859415 170 3237138 SGTC_1783 st039459 87.517 µM 2.3770264947991 0.0128176974696535 no 109 0.0087264172374804 141 729761 SGTC_2011 4012611 177 µM 2.36122763658366 0.0133176987214828 no 110 0.0091072730520397 159 2049887 SGTC_1411 3909-8223 150 µM 2.36103728556567 0.0133238242223398 no 111 0.00911194912223395 103 X1411 SGTC_2607 solasodine 47.35 µM 2.35337981117637 0.0135722681601572 no 112 0.00930181046350419 183 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1763 st044482 94.5 µM 2.33571746541634 0.0141606089240563 no 113 0.00975298580727178 142 88505 SGTC_2772 vinpocetine 57.06 µM 2.33491240320421 0.0141879416428727 no 114 0.00977399863766861 150 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1645 Cervolide 78 µM 2.33387252560484 0.0142233138559012 no 115 0.00980119887967695 96 23173 A fragrance. SGTC_2484 5809818 12.04 µM 2.32798880060116 0.0144248873781358 no 116 0.00995634918016284 127 2870548 SGTC_1460 k062-0059 9.15 µM 2.32200421837804 0.0146324344731096 no 117 0.0101163542447277 134 1373085 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.31847468395605 0.0147560403320735 no 118 0.0102117686376419 170 5379071 SGTC_245 methotrexate 289.6 µM 2.31019944084625 0.0150493691641281 no 119 0.0104385574983622 170 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_215 1287-0124 461.5 µM 2.30551486528934 0.0152176321646293 no 120 0.0105688775939154 67 5560863 SGTC_1892 st058411 7.36 µM 2.29451951866914 0.0156189282650536 no 121 0.0108803376077413 163 3934738 SGTC_3241 9133421 49.47 µM 2.28021046134961 0.0161547354975544 no 122 0.0112976045918225 52 17018221 SGTC_1274 0865-0114 173 µM 2.26651134216677 0.0166823830849825 no 123 0.0117100467529843 154 870624 SGTC_1427 4048-4900 550 nM 2.2529322924238 0.0172198890856977 no 124 0.0121317091948699 153 24132586 SGTC_3256 9138902 49.47 µM 2.25005318989272 0.0173357358825579 no 125 0.0122227845273867 65 17228773 SGTC_2794 7785382 27.27 µM 2.2462643078595 0.0174892034839935 no 126 0.0123435416513325 218 2205081 SGTC_621 3584-0052 32.1 µM 2.24419128224048 0.0175736606739895 no 127 0.0124100483540506 165 2273927 SGTC_40 0327-0103 19.753 µM 2.24113300048062 0.0176988937280072 no 128 0.0125087305769606 186 409036 SGTC_43 0570-0105 72.5 µM 2.24089947590316 0.0177084875020689 no 129 0.0125162936070427 330 1114046 YDL195W SEC31 SGTC_2037 5169046 200 µM 2.24078236854228 0.0177133002358732 no 130 0.0125200877880459 126 5718022 SGTC_355 1311-2252 105 µM 2.22377966768491 0.0184240025758391 no 131 0.0130816360128533 186 5338538 SGTC_248 streptozotocin 5.23457 mM 2.22002615161257 0.0185841287278423 no 132 0.0132084962273325 169 5300 DNA alkylating agent. SGTC_2184 6075246 200 µM 2.21952051401284 0.0186057896735577 no 133 0.013225666591612 151 2267320 SGTC_264 promethazine 12.5 mM 2.18793871330947 0.0200019766864515 no 134 0.0143370334295636 260 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2925 9010536 32.5 µM 2.18467978499279 0.0201509821054072 no 135 0.0144561666964326 245 2994177 SGTC_1718 roemerine 11.9335 µM 2.18445891575466 0.0201611147071446 no 136 0.0144642715306036 239 235224 An aporphine alkaloid with mutagenic activity. SGTC_316 k060-0003 58.6 µM 2.18316779475145 0.0202204326883101 no 137 0.01451172774378 156 6152314 SGTC_92 0063-0024 660.874 µM 2.18290445628596 0.0202325494005608 no 138 0.0145214234027921 170 3594437 SGTC_1564 D-Arginine 115 µM 2.18250615353216 0.0202508877775788 no 139 0.0145360988035128 189 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_76 0433-0009 400.328 µM 2.17587332627458 0.0205583490982439 no 140 0.0147823669094197 125 2841569 SGTC_1829 berberine 14.4 µM 2.17558619840418 0.0205717475841601 no 141 0.0147931081343776 153 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2153 5569715 200 µM 2.17110854480846 0.0207816510890437 no 142 0.0149614841414316 135 2054701 SGTC_2950 9072895 21.46 µM 2.16402058985489 0.0211176265923386 no 143 0.0152313846133871 242 17332245 SGTC_2806 7952793 58.44 µM 2.16375366067041 0.0211303685483536 no 144 0.0152416301394523 179 2972490 SGTC_2337 9009472 200 µM 2.16169452359742 0.0212288809460189 no 145 0.0153208650225128 224 5742383 SGTC_2622 2-methoxyxanthone 59.94 µM 2.1594066808861 0.0213387902770081 no 146 0.0154093150224074 162 71034 A hepatoprotective. SGTC_1472 k841-0093 193 µM 2.15919070066638 0.0213491909070132 no 147 0.0154176876091333 197 X1472 SGTC_289 k017-0060 526 µM 2.15150644799093 0.0217220287193848 no 148 0.0157181237146581 140 5512909 SGTC_1111 tnp00062 510.699 nM 2.14806734963354 0.0218906661904526 no 149 0.015854202770117 150 676306 SGTC_1591 genipin 88.4 µM 2.13147810018592 0.0227197338042621 no 150 0.0165248873722876 150 442424 A DNA cross-linking agent. SGTC_1999 st074831 12.5 µM 2.12848557056472 0.0228720719239044 no 151 0.0166484225324045 200 17112523 SGTC_3046 9092212 49.47 µM 2.12556621678042 0.0230215132968851 no 152 0.0167696975338599 138 25236637 SGTC_1746 st038117 42 µM 2.12083373485867 0.0232655152141699 no 153 0.0169678983490329 213 2898218 SGTC_2643 anethole 100 µM 2.12073481255145 0.0232706386843072 no 154 0.0169720625868714 189 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_35 0133-0054 64.071 µM 2.12004970256096 0.0233061485676725 no 155 0.0170009269945427 179 99677 SGTC_1590 st077108 57.8 µM 2.11995653550749 0.0233109810228615 no 156 0.0170048554605133 134 5489485 SGTC_1548 st061468 90.8 µM 2.11958716428775 0.0233301481329317 no 157 0.0170204379418615 140 390799 SGTC_2795 7780010 54.55 µM 2.11579751136232 0.0235275649457085 no 158 0.0171810164307874 192 953673 SGTC_203 k066-0004 30.888 µM 2.11369741001698 0.0236375707334486 no 159 0.0172705599339328 224 6795412 SGTC_1009 4106-0057 9.87 µM 2.10083462569162 0.0243208169539697 no 160 0.0178277428799943 177 2928005 SGTC_1226 3909-7979 35.4 µM 2.09000090603232 0.0249090774997053 no 161 0.0183088591574622 220 6615510 SGTC_690 glyoxal 20.3 µM 2.08870762915887 0.0249800918128845 no 162 0.0183670248416464 275 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_468 gf-109203x 121 µM 2.08145739219804 0.0253813552755407 no 163 0.0186960300864087 98 2396 A protein kinase C inhibitor. SGTC_94 0334-0113 514.748 µM 2.07276650701966 0.0258694524670224 no 164 0.0190970074383649 201 6795178 SGTC_3304 9125678 46.087 µM 2.06780870695055 0.0261513935034353 no 165 0.0193290073130049 227 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_96 0929-0093 37.281 µM 2.05646220806823 0.0268063280449473 no 166 0.0198689927105946 182 6991579 SGTC_898 1000-0849 28.3 µM 2.04753692693403 0.0273310807935577 no 167 0.0203026975099862 152 6751807 SGTC_741 4582-0002 126 µM 2.04023736501365 0.02776659476613 no 168 0.0206633449291749 208 2912688 SGTC_285 1486-1325 46 µM 2.02704325584747 0.028568466391589 no 169 0.0213289945843493 215 22310230 SGTC_1269 0831-0796 3.05 µM 2.02093865203122 0.0289459399950767 no 170 0.0216430580463021 196 927758 SGTC_2428 5615643 7.78 µM 2.01115617560425 0.0295594701690385 no 171 0.0221544815609672 213 2253075 SGTC_2924 9010168 62.78 µM 1.99099782233239 0.0308578135184886 no 172 0.0232405633294699 244 2993929 SGTC_2322 7413319 38.22 µM 1.98899350551266 0.0309894472956827 no 173 0.0233509599071897 425 1840400 SGTC_3082 9117008 49.47 µM 1.9739349571123 0.0319933496580202 no 174 0.0241945696291776 219 41448529 SGTC_2448 5185112 27.17 µM 1.96354525506222 0.0327015350717472 no 175 0.0247914257056164 200 5718189 SGTC_2005 4024620 188 µM 1.96155013723841 0.0328389954312047 no 176 0.0249074411817376 211 236743 SGTC_3227 9130768 49.47 µM 1.95994989374539 0.0329495935210953 no 177 0.02500082354885 159 17720899 SGTC_771 0250-0039 27.3 µM 1.94433033656307 0.034045316482323 no 178 0.0259278143096587 212 3005115 SGTC_1457 k015-0032 57.3 µM 1.94121887978422 0.0342671274427585 no 179 0.0261158670223113 273 4302660 SGTC_1895 st058434 18.3 µM 1.93845672164586 0.0344650314263921 no 180 0.0262837629964295 230 5393175 SGTC_3169 9102970 49.47 µM 1.93739133759795 0.0345416149277276 no 181 0.0263487623579006 157 17027839 SGTC_2106 5357045 167.29 µM 1.9328935420539 0.0348664744471476 no 182 0.026624656797089 243 668842 SGTC_205 1486-1330 71.903 µM 1.93148652704321 0.034968611595077 no 183 0.0267114569386969 177 4118834 SGTC_1065 prochlorperazine maleate 2.48 µM 1.93141345826608 0.0349739224583557 no 184 0.0267159710714195 253 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2807 7945238 51.95 µM 1.92774648082277 0.0352413011097549 no 185 0.0269433337805663 273 17148797 SGTC_216 k038-0035 28.382 µM 1.91194218388833 0.0364129284233443 no 186 0.0279418050991302 214 4444231 YPR107C YTH1 SGTC_2275 7947463 200 µM 1.91159594372604 0.0364389489838297 no 187 0.0279640200083138 217 1225414 SGTC_832 4083-0019 164 µM 1.90551247047089 0.0368986203760496 no 188 0.0283567439913669 434 1990758 SGTC_3268 9137683 49.47 µM 1.90423668884047 0.0369956181935285 no 189 0.0284396827407537 166 1953228 SGTC_357 1325-0123 420 µM 1.89269371078744 0.0378827393962288 no 190 0.0291993066366717 210 1098503 SGTC_2413 inermin 26.06 µM 1.88821481891733 0.0382316004785961 no 191 0.029498558598061 299 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1126 isoteolin 1.0172 µM 1.88813936477367 0.0382374999684034 no 192 0.0295036217044473 269 133323 SGTC_3036 9090181 49.47 µM 1.88257441181296 0.0386746542629506 no 193 0.0298790333990196 185 25236586 SGTC_2358 9037157 4 µM 1.87140902348272 0.0395640307883331 no 194 0.0306442045712277 269 2388925 SGTC_391 gliotoxin 8.33 µM 1.86914663818178 0.0397462520021734 no 195 0.0308012079609717 294 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1033 k072-0102 21.3 µM 1.86713391203857 0.0399089377143143 no 196 0.0309414448722204 286 5965931 SGTC_204 PMA1.184 62.41 µM 1.86531377245514 0.0400565225632678 no 197 0.031068717895192 286 2252213 YGL008C PMA1 SGTC_2905 7799065 20.05 µM 1.85927146056583 0.0405496419600946 no 198 0.0314943350767665 215 1296806 SGTC_537 1334-0398 209 µM 1.85896411782582 0.0405748556453277 no 199 0.0315161123201102 275 5846986 SGTC_2624 nerol 100 µM 1.85382210775225 0.0409985848913441 no 200 0.0318823072599069 217 637566 A natural product oil. SGTC_2299 7976368 114.88 µM 1.85350066952371 0.0410251918741282 no 201 0.0319053151359845 250 2979718 SGTC_512 prima-1 270 µM 1.85127166239973 0.0412100829593639 no 202 0.0320652403423346 256 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1706 st031321 9.9705 µM 1.82643024888269 0.0433166759176962 no 203 0.0338927394716049 240 6103185 SGTC_3259 9138485 49.47 µM 1.8228269763086 0.0436293364938228 no 204 0.0341648003067213 295 17646153 SGTC_1181 1222-0449 220 µM 1.81922352753933 0.0439438311483466 no 205 0.0344386673905453 266 658318 SGTC_608 k048-0125 159 µM 1.81144717563831 0.044628750736401 no 206 0.0350358295085629 286 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1555 citronellol 128 µM 1.80866396778612 0.0448759675101459 no 207 0.0352516120310766 207 8842 A terpine precursor. SGTC_170 4197-0004 226 µM 1.80688898002035 0.0450342046814428 no 208 0.0353897955548546 235 218692 SGTC_2261 9010538 184.68 µM 1.80476646627092 0.0452240124342126 no 209 0.0355556169712603 226 6457250 SGTC_1310 1188-0297 994 nM 1.80326700739468 0.045358490486629 no 210 0.0356731457298324 300 1588352 SGTC_2361 9034121 116 µM 1.79861176509294 0.0457780434857429 no 211 0.0360400574946568 267 6496917 SGTC_2487 5918373 44.05 µM 1.79846656069933 0.0457911800015936 no 212 0.0360515515763725 291 2876279 SGTC_1329 1447-1697 50.6 µM 1.79272343252618 0.0463131900205034 no 213 0.0365085788854177 300 2840515 SGTC_1478 0453-0656 35.7 µM 1.7874420207022 0.0467974403491781 no 214 0.036933037571198 285 5258496 SGTC_755 1995-0008 37.3 µM 1.78156399554174 0.0473411608383535 no 215 0.0374101800986809 267 689533 SGTC_966 1300-0360 30.2 µM 1.77869038541943 0.0476088076186415 no 216 0.0376452681678839 301 70588 SGTC_1762 st045503 25.4615 µM 1.77387343993589 0.0480601730892782 no 217 0.038042043466815 299 4645554 SGTC_2343 7990716 14.84 µM 1.7707989014531 0.0483500547427259 no 218 0.0382970743481838 298 6456862 SGTC_1703 st026983 48.3 µM 1.76896426761882 0.0485236976472697 no 219 0.0384499189222756 291 1104023 SGTC_2835 9006588 71.43 µM 1.76494089372108 0.0489062444528242 no 220 0.0387868499670879 333 2345538 SGTC_2134 5324836 1.464 µM 1.76435490558772 0.0489621613503969 no 221 0.0388361226550733 230 699272 SGTC_648 0375-0473 33.3 µM 1.76398411163553 0.0489975700963426 no 222 0.0388673271132451 331 1713139 SGTC_228 caffeine 993.056 µM 1.76200846172874 0.0491865786187137 no 223 0.0390339339134006 236 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2028 5153890 36.43 µM 1.75997576537367 0.0493816519981079 no 224 0.0392059578547364 295 2830968 YPR165W RHO1 SGTC_2947 9072639 7.68 µM 1.74661907211674 0.0506788721289906 no 225 0.0403517183348129 359 16488146 SGTC_597 k018-0003 82.8 µM 1.74156715554478 0.0511765385993368 no 226 0.0407921063595719 300 6786234 SGTC_1295 1013-0063 9.78 µM 1.74071099178937 0.0512612637243432 no 227 0.0408671252949081 303 6826038 SGTC_675 1309-0189 238 µM 1.73820085531752 0.0515103076822355 no 228 0.0410877142296027 290 4246530 SGTC_3145 9085516 49.47 µM 1.73545052348573 0.0517842863487361 no 229 0.0413305188804794 295 25236195 SGTC_644 1498-1197 63.3 µM 1.73465656785752 0.0518635925706 no 230 0.0414008267470276 337 6741615 SGTC_2560 caryophyllene 100 µM 1.73210407436234 0.0521192088078669 no 231 0.0416275169506901 343 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_686 1319-0111 510 µM 1.73171819091754 0.052157939550159 no 232 0.041661875083749 319 4562600 SGTC_1922 5578187 25 µM 1.72916746155874 0.0524145290340091 no 233 0.041889564033116 327 1350412 SGTC_454 lyso-paf C-16 6.67 µM 1.72450861056238 0.0528857699109536 no 234 0.0423080329385989 303 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3206 9114350 49.47 µM 1.71454619172627 0.0539047391582633 no 235 0.0432142306377973 302 17087243 SGTC_2597 laccaic acid a 100 µM 1.71000602820508 0.0543742400154143 no 236 0.0436323791642871 364 5491415 A textile dye. SGTC_1243 0416-0003 5.65 µM 1.70562281652632 0.0548305737746756 no 237 0.0440391642272564 341 2141977 SGTC_1920 st075728 45.7 µM 1.70460218689441 0.0549372642518882 no 238 0.04413432161462 318 3400306 SGTC_1255 0566-0045 221 µM 1.70316660048709 0.055087609405703 no 239 0.0442684475678069 349 2788469 SGTC_1842 st055362 61.2 µM 1.7030640219496 0.0550983646148157 no 240 0.0442780439801137 358 676032 SGTC_393 acivicin 6.25 µM 1.68766751405086 0.0567315637900578 no 241 0.0457375355848476 291 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2913 7966556 36.57 µM 1.68676466619136 0.0568285053985047 no 242 0.0458243060688664 292 2976516 SGTC_2166 5933061 31.504 µM 1.68670205359012 0.056835233144586 no 243 0.0458303285137813 339 2877375 SGTC_1093 fluphenazine 7.97 µM 1.68347705548018 0.0571826093390199 no 244 0.0461413887265828 371 6602611 An atypical antipsychotic. SGTC_703 3875-0075 71.8 µM 1.68299874033829 0.057234272392349 no 245 0.0461876676380611 286 2850814 SGTC_2969 9091408 28.7 µM 1.68105676922213 0.057444403067222 no 246 0.0463759441792519 351 4286311 SGTC_845 0330-0138 4.51 µM 1.67304575586318 0.0583176558684671 no 247 0.0471591444121749 326 9039800 SGTC_3239 9133757 49.47 µM 1.66805909335387 0.0588664783515804 no 248 0.0476519982966286 269 17036923 SGTC_2813 7971799 71.43 µM 1.66461011916946 0.059248430930055 no 249 0.0479952825961184 318 2234054 SGTC_2271 7849410 118.62 µM 1.66426201883666 0.0592870886127507 no 250 0.0480300395099947 315 972430 SGTC_2892 9047358 58.44 µM 1.65595807832523 0.0602151442394999 no 251 0.048865154365373 262 6466771 SGTC_1367 1812-0510 76.9 µM 1.65574689133257 0.0602388941263304 no 252 0.0488865434709334 343 1142582 YDR527W RBA50 SGTC_3229 9132204 49.47 µM 1.65572565561288 0.0602412826806903 no 253 0.0488886946472529 244 17682924 SGTC_2893 9048488 25.97 µM 1.65546997083873 0.0602700474501842 no 254 0.0489146014281915 318 6467338 SGTC_624 k048-0052 28 µM 1.6527488917897 0.0605768377348813 no 255 0.0491909897353208 324 6835531 SGTC_1596 piperlongumine 63 µM 1.64733607039608 0.0611907416511608 no 256 0.0497444938718222 358 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2887 9044784 58.44 µM 1.6465866151056 0.061276124172345 no 257 0.0498215217444025 361 6465546 SGTC_1040 k898-0338 155 µM 1.63019982762125 0.0631663708620555 no 258 0.0515296351788459 401 20969351 SGTC_1732 st034308 51.822 µM 1.62513992476898 0.0637591248825412 no 259 0.0520663737673834 378 830119 SGTC_202 3594-0513 34.79 µM 1.624566878801 0.0638265275479656 no 260 0.0521274396385923 293 708429 SGTC_569 4130-2812 160 µM 1.6220817936868 0.064119469086384 no 261 0.0523929179443287 244 743552 SGTC_2690 usnic acid 100 µM 1.62061117536312 0.0642933170480548 no 262 0.0525505269978251 421 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_362 0310-0100 9.03 µM 1.62024316481148 0.0643368783716593 no 263 0.052590026219997 385 790235 SGTC_634 1611-4317 11.2 µM 1.61709150826755 0.0647108790899252 no 264 0.052929264803053 392 2843522 SGTC_1631 benzylvanillin 81.9 µM 1.6156500613432 0.0648824943933115 no 265 0.0530849968754563 385 75506 SGTC_1212 0520-0165 585 µM 1.61377800915539 0.0651059037401394 no 266 0.0532877930743546 383 5403258 SGTC_837 0091-0265 12.5 µM 1.61044312701733 0.0655053645604699 no 267 0.0536505759739686 379 759367 SGTC_967 1306-0166 352 µM 1.60959606003731 0.0656071305234101 no 268 0.0537430344595526 391 4437607 SGTC_2034 5197015 53.07 µM 1.6053755206734 0.0661160108085014 no 269 0.0542055941317403 353 780676 SGTC_256 clotrimazole 625 nM 1.60202678294144 0.0665219471693685 no 270 0.0545748435206563 375 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1650 st011916 45.8 µM 1.60156376855825 0.0665782255998916 no 271 0.0546260540697023 322 242528 SGTC_809 3998-0021 90 µM 1.59905371503507 0.0668839590100194 no 272 0.0549043339018615 327 715485 SGTC_371 0195-0006 7.36 µM 1.59200695490808 0.0677480849904898 no 273 0.0556915709231742 310 3928593 SGTC_462 ag-879 158 µM 1.58924263185925 0.0680894123188283 no 274 0.0560028125023803 404 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2150 5556613 200 µM 1.58263852065681 0.0689102344864409 no 275 0.0567519391874432 405 743190 SGTC_2551 apiole 73.87 µM 1.58192660243443 0.0689991720212698 no 276 0.0568331635712173 224 10659 A possible DNA adduct former. SGTC_1074 carmofur 3.8 µM 1.58146171704116 0.0690572963118626 no 277 0.0568862528064813 431 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2534 helenine 20.12 µM 1.58139421499044 0.0690657391817562 no 278 0.0568939646883522 324 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2470 5664817 21.68 µM 1.58078398052183 0.0691421008236211 no 279 0.0569637192892091 327 2859561 SGTC_667 1498-1044 59 µM 1.57957643517366 0.0692933986355682 no 280 0.0571019496747162 385 6739982 SGTC_760 0568-0725 82.9 µM 1.57790166110782 0.0695036592510923 no 281 0.0572941016696731 361 3916171 SGTC_42 0133-0086 60.653 µM 1.57526663598335 0.0698354693746096 no 282 0.0575974558708928 347 162923 Model of phenazepam hydroxylation. SGTC_1907 st060210 83.7 µM 1.57369849220454 0.0700335125100761 no 283 0.0577785852972347 424 688793 SGTC_2895 9054447 58.44 µM 1.57315307709666 0.0701024949536349 no 284 0.0578416886754599 334 2697450 SGTC_1996 st072960 66.8 µM 1.57157122872426 0.0703028579609258 no 285 0.0580250116615712 377 1719405 SGTC_2513 baicalein 25.65 µM 1.5606358568893 0.0717000392441319 no 286 0.0593048467201141 381 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2482 5981709 142.65 µM 1.55862048441878 0.0719598464785554 no 287 0.0595431158898907 429 877755 SGTC_1102 cgs 12066b 26.1 µM 1.55806245265806 0.0720319113476386 no 288 0.0596092221400604 339 6438352 A 5-HT1B full agonist. SGTC_1905 st060207 84.5 µM 1.55664855588723 0.0722147513099357 no 289 0.0597769744156131 363 1948547 SGTC_3012 9080433 71.4286 µM 1.55490699820708 0.0724404518315191 no 290 0.0599841102143554 396 17688859 SGTC_2455 5377712 9.75 µM 1.55132509821264 0.0729063533537909 no 291 0.06041189753403 350 2243908 SGTC_1177 0983-0204 23.6 µM 1.5472154901968 0.0734437160831016 no 292 0.0609056459754339 408 766818 SGTC_2956 9076196 2.52 µM 1.54567639305391 0.073645742629308 no 293 0.0610913706497744 405 16423868 SGTC_2777 climbazole 1.536 µM 1.54318865148666 0.0739731890956838 no 294 0.0613925049944107 433 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_880 0833-0487 87.2 µM 1.54079898891924 0.0742887723853243 no 295 0.061682857805535 405 76075 SGTC_2098 5376439 882.5 nM 1.53861858777213 0.0745776162979583 no 296 0.0619487189909311 423 2844116 SGTC_2731 amoxapine 43.43 µM 1.53721176420465 0.0747644366590876 no 297 0.0621207302076401 217 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_980 1473-0395 201 µM 1.53058083903291 0.0756498072664049 no 298 0.0629365101416553 346 768876 SGTC_265 mycophenolic acid 32.932 µM 1.52498688468911 0.0764029127257212 no 299 0.0636311844774069 428 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2787 5284540 71.43 µM 1.52292586512799 0.0766818180332448 no 300 0.063888626941951 412 736958 SGTC_2490 carminic acid 95.39 µM 1.52235663603634 0.076758984647628 no 301 0.063959872058008 322 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2475 5812728 15.03 µM 1.51720525553305 0.0774600103597286 no 302 0.0646074349180476 442 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2457 5731572 11.68 µM 1.51221637935635 0.0781435459020273 no 303 0.0652394127560809 373 2865357 SGTC_1608 st001473 40.5 µM 1.51114738801945 0.0782906039066344 no 304 0.0653754517107772 417 7292267 SGTC_3023 9089636 49.47 µM 1.50666074406915 0.0789101079719536 no 305 0.0659488193119683 406 17249241 SGTC_1005 4092-0690 4.4 µM 1.50084621146851 0.0797184791431024 no 306 0.0666976715358008 411 1529343 SGTC_1487 3970-0795 2.82 µM 1.49975281545448 0.0798711869016938 no 307 0.0668392219524508 425 3765103 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.49847298064929 0.0800502143016997 no 308 0.0670052037454323 416 6708760 SGTC_1740 st038286 13.222 µM 1.49681432530499 0.0802826834918031 no 309 0.0672207888769039 435 716786 SGTC_1047 2043-3044 82 µM 1.49453336944442 0.0806032040824585 no 310 0.0675181334001043 443 669592 SGTC_1876 myriocin 605 nM 1.49318294321755 0.0807934213401982 no 311 0.0676946528397548 420 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_435 c-PAF 6.7 µM 1.48878582861655 0.0814151353380186 no 312 0.0682718876101483 439 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_369 0957-0393 4.5 µM 1.48849749797168 0.0814560285145677 no 313 0.06830987074966 406 6997992 SGTC_821 1114-0266 29.2 µM 1.48808862507236 0.0815140444381238 no 314 0.0683637614379995 411 3123235 SGTC_866 0495-0101 262 µM 1.48766154081331 0.0815746776812984 no 315 0.0684200874620101 379 635694 SGTC_3212 9128307 49.47 µM 1.48449145465123 0.0820257989580998 no 316 0.0688392942565427 403 27243542 SGTC_1318 1280-3875 124 µM 1.47917729370978 0.0827862469460208 no 317 0.0695464682451451 456 373245 SGTC_1282 0886-0010 32.4 µM 1.47865794335043 0.0828608487685939 no 318 0.0696158789802822 467 2836211 YNL267W PIK1 SGTC_2591 skatole 100 µM 1.4785153816541 0.0828813358167665 no 319 0.0696349415568545 414 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2181 6316240 54.2555 µM 1.47751294823011 0.0830254996743016 no 320 0.0697690950113461 396 12779990 SGTC_2974 9094440 9.66 µM 1.47682006344562 0.083125256316127 no 321 0.0698619384646189 484 25236134 SGTC_2979 9012552 45.46 µM 1.47449687852047 0.0834603898002773 no 322 0.0701739287672127 356 17100905 SGTC_781 4335-2806 94.4 µM 1.47271811926053 0.0837176722232394 no 323 0.0704135293853488 492 845254 SGTC_3247 9135149 49.47 µM 1.46645933404384 0.0846276896079414 no 324 0.0712615960420366 369 8934436 YOR116C RPO31 SGTC_1708 st033234 31.827 µM 1.46257954242645 0.0851955183771702 no 325 0.0717912322213246 471 674664 SGTC_538 2922-0838 53.3 µM 1.45743596682982 0.08595270372844 no 326 0.0724980374587142 522 777039 SGTC_1092 toremifene 6.32 µM 1.45458157457388 0.0863750654812115 no 327 0.0728925675073025 492 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1232 0279-0259 161 µM 1.45321264820342 0.0865781740140072 no 328 0.0730823607320812 455 1560000 SGTC_2208 7283366 200 µM 1.45157979261856 0.086820908543712 no 329 0.0733092404166619 450 898663 SGTC_2942 9052777 62.25 µM 1.45043727143552 0.0869910538287666 no 330 0.0734683099320633 500 6469503 SGTC_2755 lomerizine 42.69 µM 1.44979646463233 0.0870865923138186 no 331 0.0735576428491723 470 3949 A calcium channel blocker. SGTC_2700 st077718 96.8 µM 1.4492199128088 0.0871726179150649 no 332 0.0736380891359329 406 904970 SGTC_778 3456-2434 196 µM 1.44313754430047 0.0880840191932076 no 333 0.074490864485865 550 5539063 SGTC_1516 st013856 110 µM 1.44173630498986 0.0882949885858362 no 334 0.0746883888146145 421 5281404 A mutagen and neurotoxin. SGTC_329 k048-0121 21.3 µM 1.44097401376569 0.0884099165422274 no 335 0.0747960121840045 423 6832902 SGTC_2197 6588183 93.1375 µM 1.43764820301047 0.0889126415421204 no 336 0.0752669483173522 388 884136 SGTC_1166 k206-0078 225 µM 1.43626005510598 0.0891231004525564 no 337 0.0754641779430467 489 5404595 SGTC_774 k060-0086 136 µM 1.43544264109812 0.0892472029603339 no 338 0.0755805011586096 528 5911235 SGTC_2218 6965428 192.983 µM 1.43494466792761 0.0893228698990374 no 339 0.0756514328461002 452 675684 SGTC_3074 9116018 49.47 µM 1.43325563034394 0.0895798743499923 no 340 0.0758923984358324 413 17027303 SGTC_2093 5331342 194.4 µM 1.4327324911056 0.0896595867932601 no 341 0.0759671502250876 461 33839 SGTC_2871 9038510 12.99 µM 1.43221534081627 0.089738438505376 no 342 0.0760411013385393 466 4945164 SGTC_656 4090-1979 187 µM 1.42918252978063 0.0902018997287048 no 343 0.0764758888138688 506 22330961 SGTC_3296 9122258 64.045 µM 1.42799750768864 0.0903834720182678 no 344 0.0766462879429422 473 4730474 SGTC_591 4299-0174 154 µM 1.42615628116772 0.0906661279721645 no 345 0.0769116180128857 437 5509088 SGTC_3171 9103192 49.47 µM 1.42433947309762 0.0909456778900521 no 346 0.0771741130788991 413 13018434 SGTC_2087 5276107 200 µM 1.42196518970798 0.0913119689836997 no 347 0.0775181783457902 439 144405 SGTC_222 nsc-310342 10.666 µM 1.4212300894019 0.0914255975657247 no 348 0.0776249399687257 315 432556 SGTC_1362 1611-0397 101 µM 1.41452717049401 0.0924665441067676 no 349 0.0786035877678314 475 27816 SGTC_1514 1189-1591 158 µM 1.41339158132716 0.0926437635062921 no 350 0.0787703097832436 532 767698 YMR146C TIF34 SGTC_3102 9121669 49.47 µM 1.4113802989652 0.0929582594032947 no 351 0.0790662544206853 410 41905072 SGTC_2158 5657123 3.6195 µM 1.40862476317735 0.0933904115174977 no 352 0.0794730762775974 448 2858827 SGTC_1415 3966-0071 78.1 µM 1.40858655430829 0.0933964142486195 no 353 0.0794787284738054 470 2893185 SGTC_2546 rhodinyl acetate 100 µM 1.40845457460901 0.0934171508587514 no 354 0.0794982544266281 480 6708682 SGTC_1617 st002906 78 µM 1.40802389726281 0.0934848424083069 no 355 0.0795619969434917 499 5150859 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.4071264506093 0.0936260146356315 no 356 0.0796949480239153 745 16725076 SGTC_3109 9122853 49.47 µM 1.40601493785046 0.0938010785226493 no 357 0.0798598445513131 479 1234709 SGTC_1077 5-fluorocytosine 377 nM 1.40411690927492 0.0941005774975992 no 358 0.0801420195730604 446 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1883 5-benzylidenerhodanine 20 µM 1.40402929780397 0.0941144191445279 no 359 0.0801550627187779 550 1273210 SGTC_620 0109-0052 432 µM 1.40175842714825 0.0944737159195364 no 360 0.0804936983400647 470 493037 SGTC_1385 3091-4834 14.1 µM 1.40135004145313 0.0945384377867872 no 361 0.0805547119160592 439 4072814 SGTC_792 4534-1957 155 µM 1.39883342625928 0.0949379980370947 no 362 0.0809314700357403 456 1717904 SGTC_263 alizarin 107.927 µM 1.39755495525587 0.0951414553993583 no 363 0.0811233765116282 564 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_311 1315-0136 58 µM 1.39634331002281 0.0953345742312047 no 364 0.0813055687705449 487 6759207 SGTC_3220 9131269 49.47 µM 1.39602326061582 0.0953856336548886 no 365 0.0813537453485031 446 17722206 SGTC_1377 2944-0135 198 µM 1.39477635420054 0.0955847521982233 no 366 0.0815416457629071 506 1894137 SGTC_2254 7938975 95.19 µM 1.389375584171 0.0964507336121804 no 367 0.0823592853812012 595 2969277 SGTC_3325 9138760 55.175 µM 1.38797496067479 0.096676253763349 no 368 0.0825723349396598 489 43844959 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.38260803730811 0.0975439896743154 no 369 0.0833925416503125 454 2374 Ca(2+)-ATPase inhibitor. SGTC_692 k241-0027 77.8 µM 1.38216628469746 0.0976156668139586 no 370 0.083460324849438 477 3600480 SGTC_1565 sinapyl alcohol 95.1 µM 1.37891503025644 0.0981443917729426 no 371 0.0839604767207962 471 5280507 A phenol propionate derived from cinnamic acid. SGTC_3022 9087993 49.47 µM 1.37878377977892 0.0981657799376468 no 372 0.0839807146022217 429 17173644 SGTC_2791 5663188 71.43 µM 1.37392666227656 0.0989596834917761 no 373 0.0847322256673423 471 54690634 SGTC_640 3381-0960 37.1 µM 1.37045225079354 0.0995304563697448 no 374 0.0852728855210088 514 1745025 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.36151310428494 0.101010021177075 no 375 0.0866757975933105 554 688761 SGTC_1307 1187-1599 12.2 µM 1.35814240969844 0.101572064730465 no 376 0.087209250191035 499 1538471 SGTC_2959 9079155 11 µM 1.3566990052127 0.101813439138639 no 377 0.0874384343527104 434 16189457 SGTC_536 3852-0578 10.6 µM 1.35667656860755 0.101817194409659 no 378 0.0874420003878551 503 2869208 SGTC_1214 0358-0031 63.7 µM 1.35536900252986 0.102036219217281 no 379 0.08765001022263 517 4301366 SGTC_777 1315-0167 517 µM 1.35475343387471 0.102139449099841 no 380 0.0877480636503147 488 4221767 SGTC_2423 st077119 87.2 µM 1.35209364517323 0.102586364861331 no 381 0.0881726799922602 506 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_960 1222-0186 7.7 µM 1.35169574898835 0.102653344127643 no 382 0.0882363327700379 533 3126296 SGTC_1839 st053978 48 µM 1.35130794630169 0.102718654901163 no 383 0.0882984038091108 503 3788398 SGTC_3135 9127742 49.47 µM 1.35109784638091 0.102754050938767 no 384 0.0883320456334728 471 3643468 SGTC_1975 st070967 30.8 µM 1.34894784511732 0.103116776375753 no 385 0.0886768594096285 561 261391 SGTC_2353 9059630 146.67 µM 1.34874501471454 0.103151043715217 no 386 0.0887094407029136 478 4779114 SGTC_2270 7924575 90.91 µM 1.34863657980334 0.103169366727261 no 387 0.0887268626045599 543 1262135 SGTC_677 0929-0063 136 µM 1.34693124887702 0.103457839466048 no 388 0.0890011880856036 430 1539583 SGTC_1417 3966-0327 90.4 µM 1.34384831249671 0.103980832158317 no 389 0.0894987215147689 557 651118 SGTC_59 0330-0160 1.33 µM 1.34339478219455 0.104057931010437 no 390 0.089572087772662 671 4293482 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.34122413152554 0.104427509362713 no 391 0.0899238468613951 621 6708739 YPR165W RHO1 SGTC_2330 7979373 200 µM 1.33754173484046 0.105056653663976 no 392 0.0905229343749224 536 1863007 SGTC_2817 7995342 71.43 µM 1.33616544394322 0.105292498412841 no 393 0.0907476015697752 439 18879975 SGTC_2833 9001315 45.46 µM 1.33589542010026 0.105338815308049 no 394 0.0907917290654947 552 2989378 SGTC_2992 9074591 71.4286 µM 1.33413406886543 0.105641299640862 no 395 0.0910799611269012 505 17741321 SGTC_2313 7726885 200 µM 1.33256328363133 0.105911586617948 no 396 0.0913375804807873 521 726423 SGTC_3156 9099931 49.47 µM 1.33123318951897 0.106140848057275 no 397 0.0915561469220751 532 18111053 SGTC_372 0155-0182 15.9 µM 1.32967735616039 0.106409473687862 no 398 0.0918122993095436 575 771486 SGTC_2232 chlorophetanol 41.5365 µM 1.32831657680662 0.106644824013619 no 399 0.0920367728692915 681 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1911 st060208 74.3 µM 1.32827473827904 0.106652066044286 no 400 0.0920436809677789 565 688783 SGTC_3267 9137951 49.47 µM 1.32301539632896 0.107565259468558 no 401 0.0929151288935563 454 16643986 SGTC_1349 flufenamic acid 69 µM 1.32223472474759 0.107701288348207 no 402 0.0930450006547766 505 3371 A non-steroidal anti-inflammatory. SGTC_1448 4255-0083 152 µM 1.32167518740798 0.107798861693492 no 403 0.0931381672546109 532 5399660 SGTC_1192 1488-0095 21.4 µM 1.31850665607403 0.108352598430568 no 404 0.0936670491858278 509 915875 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.31735799710126 0.108553844246045 no 405 0.0938593265873433 565 6708561 SGTC_3322 9139058 2.11 µM 1.3111441176116 0.109647182326625 no 406 0.094904539003045 536 4908926 YPR165W RHO1 SGTC_340 k038-0059 454 µM 1.30807180157615 0.110190670714111 no 407 0.0954244783733524 547 23733424 SGTC_121 0557-0495 61.343 µM 1.30607613846715 0.110544734328566 no 408 0.0957633332971435 712 3104427 SGTC_2601 securinine 100 µM 1.30586922138669 0.110581491445876 no 409 0.0957985175029485 529 442872 A GABA receptor antagonist. SGTC_2923 7992654 58.14 µM 1.30546356579248 0.110653578246298 no 410 0.0958675228238017 532 2985126 SGTC_1678 st019265 80.2 µM 1.30534299001284 0.110675011589383 no 411 0.0958880407928305 578 5367020 SGTC_343 4130-2827 29.8 µM 1.30263405992177 0.111157330858694 no 412 0.0963498619358943 568 1118244 SGTC_3274 9138298 49.47 µM 1.302029434191 0.11126518833688 no 413 0.0964531619102091 566 17015756 SGTC_888 0916-0002 6.97 µM 1.30196735286329 0.111276267089751 no 414 0.0964637730759792 554 2802138 YIL048W NEO1 SGTC_545 4218-0007 221 µM 1.30161382515864 0.111339371097784 no 415 0.0965242156640082 528 2840508 SGTC_2112 5488546 200 µM 1.29829082554425 0.1119337723293 no 416 0.0970937089038192 555 600757 SGTC_3019 9081971 49.47 µM 1.29587605381509 0.1123671356496 no 417 0.0975090952107755 583 16451803 SGTC_3294 9122953 26.2835 µM 1.29511450467808 0.112504054230363 no 418 0.0976403659852656 569 16459826 SGTC_847 0342-0274 5.54 µM 1.29482535453292 0.112556071608927 no 419 0.0976902416895694 553 18097 SGTC_1758 st042942 75.2445 µM 1.29411450893572 0.112684023953108 no 420 0.0978129353302623 527 669317 SGTC_1148 3909-7663 27.7 µM 1.29383170649083 0.112734957318763 no 421 0.0978617791007264 556 4084526 SGTC_2652 actinonin 100 µM 1.2881678238329 0.113758498791863 no 422 0.0988437749475791 510 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_511 blebbistatin 171 µM 1.28800926904285 0.113787246817611 no 423 0.0988713683203783 540 3476986 A myosin inhibitor. SGTC_1558 st069300 45.6 µM 1.28690627500764 0.113987377145741 no 424 0.0990634789408106 458 24208000 SGTC_3067 9117431 49.47 µM 1.28626107366359 0.114104560472599 no 425 0.0991759814057556 498 17150885 SGTC_1384 3089-0840 101 µM 1.28625376085028 0.114105889138448 no 426 0.099177257061623 501 1069836 SGTC_1210 3013-0140 750 nM 1.28568436461584 0.114209376639951 no 427 0.0992766200627294 570 905973 SGTC_2824 7998404 51.95 µM 1.2833365216441 0.114636802028948 no 428 0.099687101364547 517 837851 SGTC_544 k015-0020 52.4 µM 1.28273458914616 0.114746567088528 no 429 0.0997925386860839 532 3008304 SGTC_1344 1488-0097 29.1 µM 1.27733645694894 0.115734283701513 no 430 0.100741743935787 556 747966 SGTC_1573 oleylamine 1.06 µM 1.27642860121855 0.115900988896176 no 431 0.100902025568227 566 5356789 An amine of the fatty acid oleic acid. SGTC_1130 3454-2858 15.9 µM 1.2763573013214 0.11591408857166 no 432 0.100914621411604 566 715628 YIL048W NEO1 SGTC_3203 9113543 49.47 µM 1.2747277715114 0.116213762868159 no 433 0.101202806789734 548 17018012 SGTC_2939 9044578 71.43 µM 1.26879877608608 0.117308756993999 no 434 0.102256420887509 552 2653634 SGTC_678 1218-2179 85.9 µM 1.26802955941127 0.117451353212451 no 435 0.102393697357699 515 6820081 YOR116C RPO31 SGTC_2618 avocadyne 43.43 µM 1.26797062179989 0.117462284037334 no 436 0.102404221046605 543 3015189 SGTC_1553 gossypol 38.6 µM 1.2666636088601 0.11770487344756 no 437 0.102637798747636 427 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2458 5808907 16.39 µM 1.2658743185116 0.117851542061592 no 438 0.102779041094487 598 2731747 SGTC_2202 7226349 200 µM 1.2630404239177 0.118379211487796 no 439 0.103287326276274 516 844334 SGTC_1331 1472-0049 76.2 µM 1.26166781976291 0.118635389020887 no 440 0.103534170535014 542 24051409 SGTC_2417 cerulenin 830 nM 1.26086779338593 0.118784883415935 no 441 0.103678241780992 539 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_918 glabranin 770.725 nM 1.26085417640797 0.118787429060612 no 442 0.103680695227193 580 124049 Also referred to as licorice root. SGTC_2320 7373003 200 µM 1.25466167312406 0.119949091300868 no 443 0.104800802332716 547 5415828 SGTC_3092 9117248 49.47 µM 1.25305260911766 0.120252244726887 no 444 0.105093280666029 602 17141857 SGTC_417 st075190 100 µM 1.24851425486747 0.121110193939049 no 445 0.105921395704176 614 222757 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.24798551918639 0.121210427659141 no 446 0.106018180143673 591 5377381 SGTC_1440 4100-1550 40 µM 1.2454814160552 0.12168592908016 no 447 0.106477421250769 531 742806 SGTC_214 4373-3496 70 µM 1.24267536970038 0.122220321842503 no 448 0.106993741857341 755 3779166 SGTC_849 0386-0493 241 µM 1.23936160606887 0.122853524989897 no 449 0.107605806646474 555 726119 SGTC_171 k064-0041 9.68 µM 1.23857302072879 0.123004548318413 no 450 0.107751832270054 484 53325 SGTC_1013 4112-3890 241 µM 1.23660915226205 0.123381217642324 no 451 0.108116110235697 611 705171 SGTC_1864 st057645 30.4 µM 1.23370383907698 0.123939936517245 no 452 0.108656641424866 541 688666 SGTC_2018 5133068 143 µM 1.2293993913173 0.124770973216739 no 453 0.109461049185091 571 785362 SGTC_1193 1488-0126 41.5 µM 1.22894352634993 0.124859212122957 no 454 0.109546490253088 603 1384710 SGTC_1452 4194-0072 190 µM 1.22802176397844 0.125037765041164 no 455 0.109719399027322 662 1343545 SGTC_2429 5902844 64.44 µM 1.22319267528919 0.125976113501581 no 456 0.110628465735613 632 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.2139644463059 0.127782897709913 no 457 0.112380650571779 629 94937 An inhibitor of serotonin biosynthesis. SGTC_706 4262-0057 46.9 µM 1.21361672509761 0.127851327950967 no 458 0.112447058650017 596 883298 SGTC_2307 7538926 6.34 µM 1.2127692951671 0.128018205654863 no 459 0.112609018910418 640 96582 SGTC_1258 0671-0043 57.1 µM 1.20815182097721 0.128930146758182 no 460 0.113494434937089 617 4298767 SGTC_3079 9117512 49.47 µM 1.2012499636659 0.130301632039229 no 461 0.114827126719551 638 7185044 SGTC_412 gemfibrozil 100 µM 1.20093719478144 0.130364021280314 no 462 0.114887782388751 566 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2993 9054257 71.4286 µM 1.20069954889708 0.130411439253689 no 463 0.11493388459338 632 6470217 YGL055W OLE1 SGTC_2804 7954240 19.48 µM 1.20001287510274 0.130548519723365 no 464 0.115067170075613 659 828705 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.1997735886967 0.130596311794006 no 465 0.115113642112294 700 65057 A dermal irritant. YDR527W RBA50 SGTC_2985 9022375 71.43 µM 1.19813970498289 0.130922966581962 no 466 0.115431316875206 630 4939335 SGTC_571 k831-0106 44.2 µM 1.19747628600901 0.131055761889942 no 467 0.115560482591813 586 4783639 SGTC_729 4092-0585 94.1 µM 1.19509896427804 0.131532389881235 no 468 0.116024183308587 583 2169061 SGTC_3014 9081533 49.47 µM 1.19433887536609 0.131685031828491 no 469 0.116172718252669 648 21367265 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.19124126012211 0.132308362467506 no 470 0.116779443095299 569 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2723 salbutamol 83.58 µM 1.19109891873354 0.132337054503639 no 471 0.116807377154195 520 9884233 β2-adrenoceptor agonist SGTC_3008 9078912 71.4286 µM 1.1908744369581 0.132382312454643 no 472 0.11685144063588 602 16648731 SGTC_2990 9074105 71.4286 µM 1.1874976099332 0.133064404518951 no 473 0.117515699388959 583 6502001 SGTC_1055 3448-0672 86 µM 1.18451383065463 0.133669113883497 no 474 0.118104862352443 621 748378 SGTC_2465 5809242 33.21 µM 1.1837661145042 0.133820945818004 no 475 0.118252829632225 612 2731748 SGTC_2680 butyl paraben 22.24 µM 1.18265675288922 0.134046432155705 no 476 0.118472605192734 604 7184 An antifungal and steroid mimetic. SGTC_2198 6589944 200 µM 1.18135999269965 0.134310339451358 no 477 0.118729872041669 532 5290268 SGTC_808 0711-0032 135 µM 1.18115176365516 0.134352749952053 no 478 0.118771219766261 635 4252555 SGTC_1587 estradiol valerate 56.1 µM 1.17912929419314 0.134765149499779 no 479 0.11917334768725 660 13791 A steroid. SGTC_1816 st051957 91.6 µM 1.17834275507341 0.134925766174381 no 480 0.119329994650121 641 674121 SGTC_3282 9108498 15.4605 µM 1.17802564044067 0.134990560282227 no 481 0.11939319221642 628 16459645 SGTC_914 3820-6779 408 µM 1.17384770120387 0.135846206175007 no 482 0.120228016794573 596 2893481 SGTC_1488 4013-0813 75.9 µM 1.17333176974297 0.135952126493607 no 483 0.120331393429252 584 2910057 SGTC_2780 5215298 71.43 µM 1.17283019983575 0.1360551525878 no 484 0.120431952464077 689 2834131 SGTC_1563 conessine 56.1 µM 1.17020101284523 0.13659608088123 no 485 0.1209600426704 742 441082 An anti-amoebic, histamine inhibitor. SGTC_1016 4226-1401 38 µM 1.1701270652477 0.136611316075796 no 486 0.120974919072839 657 2901613 SGTC_3245 9134821 49.47 µM 1.16959842036501 0.136720264989998 no 487 0.121081306665497 659 17014901 SGTC_226 1,3-diallylurea 8.28947 mM 1.16860823018624 0.136924494005624 no 488 0.12128075539606 587 74537 YKL182W FAS1 SGTC_2078 5212016 200 µM 1.16848166641077 0.136950613096972 no 489 0.121306265105805 597 1899708 SGTC_1753 st043925 64 µM 1.16300556470086 0.13808398316128 no 490 0.122413622341402 668 670181 SGTC_2656 pseudo-anisatin 100 µM 1.16298874509418 0.138087474082327 no 491 0.122417034433241 625 6708809 A neurotoxin. SGTC_2092 5303694 80.6725 µM 1.16151575533481 0.138393427575411 no 492 0.122716109863341 670 1963699 SGTC_1112 tnp00069 1.16933 µM 1.15945007592822 0.138823265897853 no 493 0.123136387566777 711 145826 SGTC_469 w7 172 µM 1.15894949049211 0.138927567275728 no 494 0.123238387043939 607 45115570 A P450 inhibitor. SGTC_1044 1222-0021 1.78 µM 1.15853917027636 0.139013100883601 no 495 0.123322038189873 649 4306703 SGTC_3063 1327-0034 4 µM 1.15816961631906 0.139090167208489 no 496 0.123397412445251 624 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1123 mangostin 811.285 nM 1.15732807689011 0.139265769295051 no 497 0.123569173303271 630 5281650 An antioxidant. SGTC_451 chloral hydrate 100 µM 1.15717360260294 0.139298019467236 no 498 0.123600720173083 715 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3104 9120930 49.47 µM 1.15520225456012 0.13971003135513 no 499 0.124003805847775 587 17014836 SGTC_2962 9082311 13.18 µM 1.15171130217076 0.140441671593157 no 500 0.12471986317787 621 16459453 SGTC_3038 9091290 49.47 µM 1.14884634909899 0.14104405393065 no 501 0.125309671813641 662 25236843 SGTC_153 4077-0274 519.67 µM 1.14688241553689 0.1414579996168 no 502 0.12571511058155 623 3121976 SGTC_2653 dihydrofissinolide 100 µM 1.14562321555279 0.141723838672783 no 503 0.125975543572065 643 6857746 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.14354516553984 0.142163290817654 no 504 0.126406156788343 672 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2190 6049624 200 µM 1.13870108961693 0.143191260863366 no 505 0.127413924063569 605 2265554 SGTC_929 2805-0021 398 µM 1.137598637102 0.143425913910022 no 506 0.127644057997772 645 3098024 SGTC_312 4092-0653 6.84 µM 1.13740291110358 0.14346760060626 no 507 0.127684945448001 766 1148278 SGTC_373 0844-0104 25.9 µM 1.13738565049728 0.143471277248448 no 508 0.12768855165095 717 5375804 SGTC_812 4251-0442 148 µM 1.13687691493687 0.143579670410678 no 509 0.127794871930823 655 5723007 SGTC_3094 9117742 49.47 µM 1.13361940351276 0.14427503827562 no 510 0.128477115148877 707 17149698 SGTC_1649 st011737 51.3 µM 1.1324369167779 0.14452801963333 no 511 0.128725395853586 666 1761035 SGTC_2023 5144124 124 µM 1.13046169362561 0.144951265341076 no 512 0.129140865436933 673 2830192 SGTC_2228 7354201 200 µM 1.12876536148644 0.145315416381886 no 513 0.129498414207152 663 753451 SGTC_2317 5986382 200 µM 1.12528172359074 0.146065176045888 no 514 0.130234835946306 705 877883 SGTC_2100 5377183 190 µM 1.12264821792147 0.146633689458225 no 515 0.130793464130229 740 2844202 SGTC_2858 9025781 8.96 µM 1.12109510152834 0.146969666822236 no 516 0.131123691775226 791 4894980 YPL153C RAD53 SGTC_1751 st044839 27.194 µM 1.11802698059402 0.147634893245511 no 517 0.131777735157846 682 5291326 SGTC_1423 4048-0112 5.59 µM 1.11753140522442 0.147742532212988 no 518 0.131883589684098 692 X1423 SGTC_1994 st072947 40.9 µM 1.11543524988106 0.148198398285194 no 519 0.132331975545048 709 5286565 YDL195W SEC31 SGTC_592 k241-0073 46.5 µM 1.11530309054207 0.148227171437909 no 520 0.132360280746431 720 4230158 SGTC_2698 st077697 67.5 µM 1.11446406264395 0.148409928099123 no 521 0.132540076721609 650 3154499 SGTC_1691 st019933 84.6 µM 1.1126235854945 0.148811347627227 no 522 0.132935063271708 669 6176082 SGTC_1134 3477-0009 42.5 µM 1.10680627514497 0.150084906744234 no 523 0.134188847293003 750 3973534 SGTC_2342 7990637 118.86 µM 1.10488857014164 0.150506329621874 no 524 0.134603937838839 721 2033102 YER133W GLC7 SGTC_1815 st051655 58.2 µM 1.10247652608702 0.151037503539278 no 525 0.135127279100175 674 5984156 SGTC_913 3487-1245 167 µM 1.1003684349543 0.151502762129921 no 526 0.13558581285382 683 4016153 SGTC_1021 4476-0760 85.3 µM 1.10022591311931 0.151534251244594 no 527 0.135616851396588 688 746768 SGTC_1386 3228-0095 33.8 µM 1.10014157908127 0.151552886257359 no 528 0.135635220037005 682 870181 SGTC_2786 7743617 45.45 µM 1.09934685079957 0.151728569551923 no 529 0.135808402038866 619 583674 SGTC_3345 9148410 3.559 µM 1.0914042212471 0.153491807388337 no 530 0.13754752789936 695 4903596 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.08961759059108 0.153890295809166 no 531 0.13794081555172 669 2346 DNA damaging agent; causes G2/M arrest. SGTC_509 pifithrin 175 µM 1.08924934736894 0.153972513454818 no 532 0.13802197149064 748 4817 A p53 inhibitor. SGTC_1938 st074717 56.4 µM 1.08511504315157 0.15489757404701 no 533 0.138935352729078 653 17250979 SGTC_2155 5570423 76 µM 1.08466724534906 0.154997989771454 no 534 0.139034530000339 685 797402 SGTC_501 nsc-95397 161 µM 1.08238449244613 0.155510550162652 no 535 0.139540858039249 709 262093 SGTC_2213 7173844 200 µM 1.08114532670842 0.155789255309087 no 536 0.139816236798907 743 892728 SGTC_70 0141-0289 43.283 µM 1.07960040980928 0.156137189017417 no 537 0.140160079441059 911 352408 SGTC_823 0417-1665 178 µM 1.07327514588531 0.157567049560407 no 538 0.141573841597946 733 3429856 SGTC_1121 fusaric acid 630.51 nM 1.07293714776832 0.157643697289671 no 539 0.141649658662302 736 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_684 1140-0066 328 µM 1.07057196356652 0.158180734711012 no 540 0.142180967661902 764 6813534 SGTC_841 0251-0215 91.2 µM 1.0679726655008 0.158772313114652 no 541 0.142766421055399 782 3888614 SGTC_1968 st069590 43.6 µM 1.06770178469384 0.158834046649911 no 542 0.142827526574738 709 6384066 SGTC_924 2046-0044 21.3 µM 1.06737851005117 0.158907741290451 no 543 0.142900474273796 742 3623589 SGTC_1041 0206-0046 107 µM 1.0644382222374 0.159579046558516 no 544 0.14356511321305 734 50494 SGTC_1717 st033143 58.0435 µM 1.06239571805048 0.160046467274309 no 545 0.144028038438058 765 674616 SGTC_2581 avocatin a 64 µM 1.05904341256224 0.160815570431734 no 546 0.14479000457945 754 6710728 A skin care supplement. SGTC_3037 9091026 49.47 µM 1.05860645728537 0.160915996427863 no 547 0.144889522446357 831 25236398 YIL048W NEO1 SGTC_260 nsc-65238 3.989 µM 1.05793696986669 0.161069944982148 no 548 0.145042089520838 719 3246252 SGTC_1605 st000082 49.1 µM 1.05776968830528 0.161108426360663 no 549 0.145080227591879 765 1114022 SGTC_2683 piperine 63.03 µM 1.05708426605375 0.16126616324398 no 550 0.145236565639866 729 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3147 9097027 49.47 µM 1.05690712664621 0.161306944882972 no 551 0.145276987816124 789 25236841 SGTC_1046 2001-0062 216 µM 1.05573866906688 0.161576119688715 no 552 0.145543812623507 738 739778 SGTC_1546 5-methoxyflavanone 78.7 µM 1.05406984889096 0.161961069309599 no 553 0.14592546956887 787 147795 SGTC_1048 3161-0300 24.5 µM 1.05360012654051 0.162069528630035 no 554 0.146033015621627 763 2165101 SGTC_1207 2099-0101 141 µM 1.05115346079412 0.162635230684935 no 555 0.146594056905433 795 5837381 SGTC_2864 9034755 47.6 µM 1.0463769316872 0.1637433257394 no 556 0.147693519486591 757 4930451 SGTC_2857 9024691 58.44 µM 1.04636835570098 0.163745319658199 no 557 0.14769549846273 713 16478292 SGTC_2006 4011487 200 µM 1.04582077491221 0.163872664949304 no 558 0.147821893795707 773 45595294 SGTC_1380 2291-0730 164 µM 1.0439609153238 0.164305673288833 no 559 0.148251736490062 714 2999191 SGTC_2878 9043973 25.97 µM 1.04286414637923 0.164561367988215 no 560 0.148505608547629 733 6465167 SGTC_2718 lomofungin 53.02 µM 1.04274679053584 0.164588742950695 no 561 0.148532790427222 739 5351222 A RNA synthesis inhibitor. SGTC_2649 anisomycin 9.56 µM 1.04239568816782 0.164670660320089 no 562 0.1486141323794 743 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_491 tetrandrine 80.3 µM 1.0383629021618 0.165613462685148 no 563 0.149550567008886 728 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2916 7875993 68.79 µM 1.03747136832284 0.165822359606398 no 564 0.149758116303 763 1299250 SGTC_2431 5490079 200 µM 1.03380481658514 0.166683265841966 no 565 0.150613709731427 783 5722345 SGTC_2132 5317594 122.667 µM 1.03345002092692 0.166766724634057 no 566 0.150696674053418 707 794577 SGTC_1240 0356-0016 42.1 µM 1.0323052551723 0.167036192363581 no 567 0.150964570008224 759 4305613 SGTC_3110 9122132 49.47 µM 1.03113480836549 0.167311995317124 no 568 0.151238803307017 800 918317 SGTC_3255 9139072 49.47 µM 1.03112752289585 0.16731371297676 no 569 0.151240511314764 771 17646060 SGTC_547 1120-0019 610 nM 1.02966597015012 0.167658525960509 no 570 0.151583417678782 767 3676939 SGTC_3148 9097893 49.47 µM 1.02799097416484 0.16805425737003 no 571 0.151977036707167 706 17174100 SGTC_1422 4031-0024 15.5 µM 1.02770271692153 0.168122421060723 no 572 0.152044844707394 776 782427 SGTC_3193 9111931 49.47 µM 1.02717014315699 0.168248404644833 no 573 0.152170177190568 771 17087244 SGTC_1502 4534-4282 27.7 µM 1.0215527418988 0.169580932291864 no 574 0.153496317229914 742 3278949 SGTC_404 fumagillin 50 µM 1.02067055353187 0.169790813434249 no 575 0.153705275082797 798 12015870 A methionine aminopeptidase binder. SGTC_2580 diallyl disulphide 81.36 µM 1.01922365064137 0.170135406107371 no 576 0.154048400503459 731 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1080 nisoldipine 24.4 µM 1.01831978927628 0.17035089592047 no 577 0.154263003447926 802 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1792 st045773 43.6 µM 1.01782773879132 0.170468279259149 no 578 0.154379913598456 762 2919270 SGTC_2961 9083290 32.55 µM 1.0177588403556 0.170484719771768 no 579 0.154396288394905 744 17741490 SGTC_1456 k015-0012 13 µM 1.01689166864224 0.170691730689599 no 580 0.15460248356398 871 2989616 SGTC_574 1315-0397 40 µM 1.01685912298012 0.17069950310964 no 581 0.154610225778598 900 6794277 SGTC_1775 st081588 35.1725 µM 1.01661221586245 0.170758475821744 no 582 0.154668970304953 818 1426443 YGL099W LSG1 SGTC_3337 9144342 33.5465 µM 1.01479272951094 0.171193454399255 no 583 0.155102320094719 796 17682949 SGTC_2082 5219693 150 µM 1.01145707602013 0.171992736404672 no 584 0.155898857693444 778 2834649 SGTC_1139 k015-0024 46.9 µM 1.00739656336583 0.172968917271008 no 585 0.156872121080898 799 2766652 SGTC_2054 5233173 129 µM 1.00738594225145 0.172971475294912 no 586 0.156874672084474 827 6889 SGTC_606 k015-0008 38.6 µM 1.00705249029563 0.173051797210683 no 587 0.156954775219045 886 1970475 SGTC_2137 5261020 140 µM 1.00682275287877 0.173107150187547 no 588 0.157009979293923 790 763655 SGTC_2655 perillic acid 100 µM 1.00647304632923 0.173191430196295 no 589 0.15709403551243 746 5702197 An apoptosis inducer. SGTC_49 0717-0965 32.132 µM 1.00546971625147 0.173433379849377 no 590 0.157335362324518 806 5889349 YGL099W LSG1 SGTC_1305 1181-0477 144 µM 1.001066069616 0.174497847132116 no 591 0.15839743379446 794 6252086 SGTC_2696 st077691 74.316 µM 1.00099524011675 0.174515002163444 no 592 0.158414554795668 720 757133 SGTC_2936 9038235 15.59 µM 0.999376323304426 0.174907398713258 no 593 0.158806212493341 768 4749415 SGTC_352 k048-0007 5.11 µM 0.999204621562692 0.174949048967957 no 594 0.158847788766781 848 6811911 SGTC_3276 9139060 49.47 µM 0.998717821977446 0.175067167751789 no 595 0.158965702374057 751 4870619 SGTC_2159 5658611 73.75 µM 0.998284054849282 0.175172461166164 no 596 0.159070818660135 825 793844 SGTC_63 0099-0242 26.702 µM 0.996090755932614 0.175705481331541 no 597 0.159603025467246 853 3898502 YLR359W ADE13 SGTC_2809 7964133 12.99 µM 0.993923525937903 0.176233174360513 no 598 0.160130049942764 803 1253665 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.992710103927612 0.176529064760434 no 599 0.1604256247836 772 6708514 SGTC_1942 st076330 65.2 µM 0.991134224826333 0.176913808272441 no 600 0.160810021536599 788 24208414 SGTC_2260 7964312 200 µM 0.989610318715139 0.177286366428876 no 601 0.161182312226698 762 231951 SGTC_2875 9039966 71.43 µM 0.988896886656407 0.177460953438037 no 602 0.161356796974205 806 6463691 SGTC_1814 st052110 31.539 µM 0.988490831233047 0.177560369444172 no 603 0.161456161319922 801 674163 SGTC_2328 6201408 200 µM 0.984168544888079 0.178620787887063 no 604 0.162516324487185 779 2890418 SGTC_3281 9140613 49.47 µM 0.983382859020314 0.178813973495751 no 605 0.162709521643596 743 16013766 SGTC_2981 9013952 38.96 µM 0.983254800248634 0.178845473237612 no 606 0.162741024959866 732 2996344 SGTC_1084 voriconazole 435 nM 0.980522286978778 0.1795184457776 no 607 0.163414186934306 846 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1844 rapamycin 4 nM 0.979430409384766 0.179787801556561 no 608 0.163683678932864 892 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1178 0988-0033 191 µM 0.978488466208132 0.180020373819462 no 609 0.163916396515231 825 5392207 SGTC_1784 st039334 36.3 µM 0.978443959008574 0.180031367625552 no 610 0.163927397825335 802 3496984 SGTC_785 1270-0111 65.3 µM 0.974715283093594 0.180953891446702 no 611 0.164850754905608 817 6741994 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.974264325815232 0.181065664711898 no 612 0.164962656390543 850 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.974067820003258 0.181114383732208 no 613 0.165011433137682 806 279621 SGTC_1105 epirubicin 18.1 µM 0.973046116100142 0.181367823647174 no 614 0.165265191347885 803 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1603 st002045 67.8 µM 0.972564071180614 0.181487474902471 no 615 0.165385003353554 848 5887985 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.971604682110033 0.181725757596147 no 616 0.16562362617302 752 61125 An anti-inflammatory. SGTC_2694 st077685 81.9 µM 0.969825071760903 0.182168275988739 no 617 0.166066846716674 793 2838096 SGTC_1716 st033144 30.6155 µM 0.969313731169105 0.182295550545434 no 618 0.166194340160505 872 674617 SGTC_1851 st056236 18.9 µM 0.968822738448657 0.182417812722415 no 619 0.166316819718927 876 5393171 SGTC_2242 6630449 61.2675 µM 0.968660751958721 0.18245816024022 no 620 0.16635724050335 722 691249 YDR170C SEC7 SGTC_2869 9037858 32.47 µM 0.968654556499727 0.182459703512873 no 621 0.166358786593476 830 27187042 SGTC_2405 ticlatone 3.52 µM 0.968426428705404 0.182516535228473 no 622 0.166415722836428 828 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2333 9017922 200 µM 0.968240610100191 0.182562834952389 no 623 0.166462108828626 836 3163164 SGTC_2368 9071271 200 µM 0.966646879861394 0.182960239927182 no 624 0.166860295281367 803 27209959 SGTC_3340 9146634 11.102 µM 0.966149105516113 0.183084473114141 no 625 0.16698478781937 833 4907387 SGTC_2575 plumbagin 510 nM 0.965457593280098 0.18325714619663 no 626 0.167157833265854 813 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2369 9071472 200 µM 0.96474754412225 0.18343455365662 no 627 0.167335637686419 859 17296037 SGTC_3286 9117135 37.221 µM 0.963765981238121 0.183679975695692 no 628 0.167581632878872 785 3438150 SGTC_1680 diphenhydramine 100 µM 0.962066779668941 0.184105313669083 no 629 0.168008030048371 821 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_441 propafenone 146 µM 0.961250376567802 0.184309890613176 no 630 0.168213146132672 806 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1378 2093-0007 380 nM 0.960726309704465 0.184441287504509 no 631 0.16834489946054 815 3618014 SGTC_2001 4023502 57.655 µM 0.96009574737191 0.184599462732843 no 632 0.168503514289867 822 108941 YCR052W RSC6 SGTC_3047 9092122 49.47 µM 0.959933692425282 0.184640127494857 no 633 0.16854429392386 793 17173831 SGTC_1914 st062367 72.6 µM 0.959279358280025 0.184804377473404 no 634 0.168709015605225 798 978205 SGTC_1168 k815-0004 80.5 µM 0.959021736468014 0.184869070225217 no 635 0.168773897540956 844 642433 SGTC_2168 5727979 200 µM 0.957115674496145 0.185348148532186 no 636 0.169254436463766 770 695210 SGTC_2836 9010338 19.48 µM 0.955594000295103 0.185731165840069 no 637 0.169638696932561 786 2994051 SGTC_992 3909-8734 162 µM 0.954674443685778 0.185962863271523 no 638 0.169871178834339 829 4288319 SGTC_62 0180-0423 3.232 µM 0.954646899638626 0.185969806211164 no 639 0.169878145658004 838 30102 YGL099W LSG1 SGTC_1109 tnp00067 928.257 nM 0.953333169732889 0.186301140518983 no 640 0.170210645236999 849 676295 SGTC_622 1348-1566 26.3 µM 0.953221548201461 0.186329309305695 no 641 0.170238915389623 900 7340407 SGTC_2982 9019404 25.97 µM 0.953170069759438 0.186342301283794 no 642 0.170251954240898 722 22333232 SGTC_654 1124-0271 80.9 µM 0.952544307815296 0.186500274118774 no 643 0.170410503142316 856 5403748 SGTC_3052 9092717 49.47 µM 0.952484585341652 0.186515355318455 no 644 0.170425639928826 816 25237534 SGTC_3307 9126885 69.2785 µM 0.951788746056798 0.186691125253516 no 645 0.170602065319439 837 24824909 SGTC_3066 9117245 49.47 µM 0.951334735821782 0.186805864108882 no 646 0.170717239585042 895 17176980 SGTC_3295 9122362 53.5725 µM 0.95108132698881 0.186869925338988 no 647 0.170781546504152 794 4730473 SGTC_408 cantharidin 100 µM 0.951045796700088 0.186878908409235 no 648 0.170790564174763 867 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2922 7999257 32.47 µM 0.950953574152944 0.186902226146117 no 649 0.170813971895469 788 2988377 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.950629170961991 0.186984263214423 no 650 0.170896327499688 824 5355888 SGTC_3196 9111891 49.47 µM 0.946090085883137 0.188134470392646 no 651 0.172051320005263 857 18891510 SGTC_1600 coumarin 106 71.1 µM 0.945832729977815 0.188199815092325 no 652 0.172116954405106 889 100336 A hepatotoxic, DNA x-linker. SGTC_3085 9117376 49.47 µM 0.945502972195396 0.188283563667739 no 653 0.172201077068848 869 16480349 SGTC_819 1013-0258 27.7 µM 0.944231576584944 0.188606675146162 no 654 0.172525661229842 844 5753198 SGTC_2720 fluspirilene 36.88 µM 0.944166799646606 0.188623146653488 no 655 0.172542209061301 783 3396 An atypical antipsychotic. SGTC_304 1310-0298 97 µM 0.942749653690209 0.188983721026532 no 656 0.172904484565272 870 1550234 SGTC_752 1896-0090 130 µM 0.939343247770337 0.189852172187832 no 657 0.173777270424054 881 772567 SGTC_1140 3229-1848 2.98 µM 0.939142163028889 0.189903514619755 no 658 0.173828879598459 879 2849525 SGTC_162 k030-0015 37.8 µM 0.936223187938072 0.190649769784498 no 659 0.174579143385936 940 1809920 YMR134W ERG29 SGTC_3347 9188721 44.724 µM 0.934108860543473 0.191191433953176 no 660 0.175123870914001 827 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1000 4048-0884 8.67 µM 0.933037959433981 0.191466144989395 no 661 0.175400184813416 835 13040088 SGTC_1727 st034309 9.9045 µM 0.932620945985839 0.191573184027466 no 662 0.17550785734898 946 870305 SGTC_1623 st003709 20.3 µM 0.931428791750495 0.191879388380675 no 663 0.175815901620777 899 16192618 SGTC_1910 st062352 60.4 µM 0.930567594909767 0.192100772736119 no 664 0.176038641747684 877 2245730 SGTC_137 0438-0332 85.389 µM 0.929161138812095 0.192462660534481 no 665 0.176402791794351 950 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1510 1123-0200 71.5 µM 0.928537203743614 0.192623335351868 no 666 0.176564489306216 929 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2148 5546263 113.568 µM 0.927491627693866 0.192892774251556 no 667 0.176835668365724 878 792097 SGTC_1225 1216-0074 20.6 µM 0.927243822449497 0.192956665958676 no 668 0.17689997733743 890 4241466 SGTC_3228 9131799 49.47 µM 0.925982510150853 0.193282070789885 no 669 0.177227534781769 850 17015818 SGTC_2952 9073731 13.78 µM 0.925340471760287 0.193447838247266 no 670 0.177394416446482 918 16457353 SGTC_2677 mitomycin C 100 µM 0.924100830949334 0.193768145571112 no 671 0.177716910360258 849 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1364 1653-0028 37.6 µM 0.923737473290625 0.193862093781223 no 672 0.177811508309825 855 5718652 SGTC_1865 st057639 52.2 µM 0.923542665768389 0.193912473815802 no 673 0.177862238336793 905 688818 SGTC_389 tpck 16.7 µM 0.923254237881165 0.193987080077657 no 674 0.177937364900918 876 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1928 4'-methoxychalcone 40.3 µM 0.923206014046526 0.193999555612699 no 675 0.177949927674051 915 641818 SGTC_2689 tacrolimus 100 µM 0.920232511779022 0.194769746571795 no 676 0.178725633969489 850 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1934 st074720 32.6 µM 0.920040543815942 0.194819533585297 no 677 0.178775786268237 929 17250992 SGTC_473 2-arachidonoylglycerol 10 µM 0.919937549707468 0.194846248363178 no 678 0.17880269748907 848 5282280 An endocannabinoid. SGTC_1241 0364-0022 50.8 µM 0.917501479488139 0.195478769559065 no 679 0.17943995900161 901 4563895 SGTC_2040 5100729 123 µM 0.916904447830006 0.195633977799837 no 680 0.179596356520929 897 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3237 9133362 49.47 µM 0.91663488131941 0.195704080576954 no 681 0.179666999823676 891 43845137 SGTC_931 2812-0076 566 µM 0.915577058817584 0.195979322487415 no 682 0.179944384208691 903 3450959 SGTC_91 0417-1751 58.384 µM 0.915441158934773 0.196014700202121 no 683 0.179980039639114 1019 6795624 SGTC_1899 st063254 59.6 µM 0.914373157262038 0.196292859249123 no 684 0.180260400760332 801 3093813 SGTC_1879 gemcitabine 100 µM 0.913193726963398 0.196600317569467 no 685 0.180570331288848 893 60750 A nucleoside analog which inhibits DNA replication. SGTC_1627 st003713 25.6 µM 0.912027501609889 0.196904620271306 no 686 0.180877120225841 963 16195070 YER133W GLC7 SGTC_883 0850-0245 24.6 µM 0.908363093846886 0.197862626729632 no 687 0.181843208913766 924 6823229 YPR165W RHO1 SGTC_2889 9059656 51.95 µM 0.908331081778458 0.197871008210132 no 688 0.18185166280825 944 3949838 SGTC_324 1315-0088 19.6 µM 0.905752138266533 0.198546938171111 no 689 0.182533529572937 843 6787421 SGTC_2822 7994718 71.43 µM 0.904361441155827 0.198912011206431 no 690 0.182901888561409 807 1018011 SGTC_1527 coumarin 137 µM 0.903852936359182 0.199045600164729 no 691 0.183036693820106 852 323 A hepatotoxic, DNA x-linker. SGTC_2108 5365811 200 µM 0.903684339078536 0.199089904174728 no 692 0.183081402850691 948 780283 SGTC_299 1273-0059 1.44 µM 0.903511217226378 0.199135403333953 no 693 0.183127318806993 867 2848077 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.902707047813813 0.199346833880947 no 694 0.183340697474348 936 23665772 A membrane-active detergent. SGTC_2823 7987624 58.44 µM 0.90228721594682 0.199457268884235 no 695 0.183452157414294 888 2239440 SGTC_515 4092-1064 102 µM 0.90167013061055 0.199619657413448 no 696 0.183616062255527 976 717353 SGTC_2452 5863136 48.41 µM 0.90164589838225 0.199626035846378 no 697 0.183622500470826 905 2184096 SGTC_2375 9072683 200 µM 0.900517320379127 0.199923237197771 no 698 0.183922506069992 999 16798029 SGTC_1795 st049545 62.3 µM 0.900257354059936 0.199991734786926 no 699 0.183991655157957 918 5291882 SGTC_944 3370-0224 231 µM 0.898810756654086 0.200373151179431 no 700 0.184376734791366 897 4580514 SGTC_2395 5646831 180.19 µM 0.898523813440048 0.200448859824393 no 701 0.184453177714323 900 6808628 SGTC_489 paxilline 115 µM 0.895249189130437 0.201314070636364 no 702 0.185326947648832 864 105008 A toxic potassium channel blocker. SGTC_349 k015-0014 24 µM 0.894889850727905 0.201409150005989 no 703 0.185422986356291 849 2196908 SGTC_2404 5161160 200 µM 0.894337768270927 0.201555281036922 no 704 0.18557059905512 946 2831543 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.89425525686529 0.20157712648455 no 705 0.185592666752328 909 364106 SGTC_2762 leflunomide 42.06 µM 0.892632338363856 0.202007093309814 no 706 0.186027047690307 934 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3315 9136395 68.55 µM 0.892037026903164 0.202164949256208 no 707 0.186186543173424 978 16876844 SGTC_1229 0139-0193 12.2 µM 0.891921472627318 0.202195598792355 no 708 0.186217512223341 970 3090752 SGTC_147 4466-0538 29.23 µM 0.890967211751224 0.202448812539498 no 709 0.186473380313915 972 6742687 YHR072W ERG7 SGTC_1481 3346-2004 36 µM 0.888229329937952 0.203176362907538 no 710 0.187208702461674 951 2770522 SGTC_524 r073-0010 27.8 µM 0.88422483712627 0.204243302205824 no 711 0.188287426649564 891 2772106 SGTC_2943 9068529 45.32 µM 0.882698124014119 0.204650949742247 no 712 0.188699698005078 1023 3270634 SGTC_405 ebelactone b 50 µM 0.882504784648513 0.204702607777636 no 713 0.188751946747321 919 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2726 cimetidine 79.27 µM 0.880798645468579 0.205158804516994 no 714 0.189213406515433 946 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1330 1469-0054 61.8 µM 0.879712998099742 0.205449405054262 no 715 0.189507403067968 989 7102664 SGTC_696 1560-0013 611 µM 0.877653109669725 0.206001456883484 no 716 0.190065999112272 931 1650269 SGTC_1659 st012954 42.1 µM 0.877397237736951 0.206070092151486 no 717 0.190135456490923 908 24207262 SGTC_3143 9086658 49.47 µM 0.873987357352567 0.206986054672948 no 718 0.191062569387902 976 25236626 SGTC_603 3794-0023 45.9 µM 0.873333687043473 0.207161918462072 no 719 0.191240612053933 942 3802260 SGTC_100 0086-0128 49.5915 µM 0.87159545057771 0.207630004268049 no 720 0.191714556720479 986 93297 SGTC_1725 st036284 20.55 µM 0.870927802292152 0.207809959760271 no 721 0.191896787621103 1010 707914 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.87063516772936 0.20788886444402 no 722 0.191976694014994 963 442882 SGTC_2781 5567276 71.43 µM 0.869829031505899 0.208106318908813 no 723 0.192196921766852 907 2853274 SGTC_2525 harmine 47.85 µM 0.866727508248942 0.208944202736341 no 724 0.193045664769205 911 5280953 A monoamine oxidase inhibitor SGTC_2481 5478948 45.16 µM 0.86653308445811 0.208996792887826 no 725 0.193098945657404 903 77792 SGTC_1852 st056254 31.4 µM 0.86620392615236 0.209085845467302 no 726 0.19318917034425 942 442583 SGTC_2722 naftopidil 47.16 µM 0.865374463560067 0.209310352621194 no 727 0.193416646177795 963 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3288 9119690 36.221 µM 0.863825467709404 0.209729992490593 no 728 0.193841887597053 882 17595618 YKL019W RAM2 SGTC_2294 7971431 200 µM 0.862170700446095 0.210178833029037 no 729 0.19429679516122 867 5741572 SGTC_2492 derrusnin 100 µM 0.861669831695486 0.210314800262285 no 730 0.194434615684604 882 1715307 Part of coumarin class of compounds. SGTC_564 3555-0129 330 µM 0.861120650990791 0.210463941737352 no 731 0.194585798246005 872 563260 SGTC_2877 9040724 71.43 µM 0.860443118548286 0.210648025314257 no 732 0.194772412966355 964 6463895 SGTC_3221 9128209 49.47 µM 0.859760813198836 0.210833501108652 no 733 0.194960452278854 932 16460723 SGTC_570 0987-0065 62.6 µM 0.858659309775757 0.211133132453047 no 734 0.195264252938833 859 3104428 SGTC_566 0958-0068 16.5 µM 0.853724835729584 0.212478469401068 no 735 0.196628734918053 904 6815365 SGTC_2566 crystal violet carbinol 226 nM 0.853222082537038 0.212615820778359 no 736 0.196768079848046 837 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1404 3909-7820 48.3 µM 0.851277661166728 0.213147521458995 no 737 0.197307565515209 979 23741373 SGTC_1674 st016616 23.6 µM 0.851236066522567 0.213158903951815 no 738 0.197319115842292 948 625830 SGTC_359 0081-0058 15.9 µM 0.85046558866386 0.213369811509997 no 739 0.197533142122596 897 3494159 SGTC_769 0302-0231 76 µM 0.84975799571899 0.21356361232154 no 740 0.197729823574215 1029 571869 YER009W NTF2 SGTC_3163 9099914 49.47 µM 0.848418578365825 0.213930742601313 no 741 0.198102449849212 971 16268368 SGTC_3158 9100007 49.47 µM 0.847934872822969 0.214063415091093 no 742 0.198237121005053 946 19297233 SGTC_2844 9010103 25.97 µM 0.846385017983527 0.214488837225344 no 743 0.19866899678719 919 2480525 SGTC_2437 5741531 144.16 µM 0.842460045503508 0.21556840535142 no 744 0.199765247501497 1036 2262990 SGTC_1497 4476-2978 41.3 µM 0.842215545796342 0.215635759370834 no 745 0.199833656823115 1025 1528379 SGTC_2489 cantharidin 73.42 µM 0.838123509321389 0.216764830622465 no 746 0.200980670320743 980 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_701 4424-0219 185 µM 0.836699538022868 0.217158531933512 no 747 0.201380739446993 1050 2911779 SGTC_278 4092-0821 23.9 µM 0.836027149140154 0.217344578318181 no 748 0.201569814966158 979 877900 SGTC_2750 bromebric acid 70.15 µM 0.835790726610237 0.217410017024337 no 749 0.201636322163671 1023 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1515 3460-0031 42.1 µM 0.834769539832287 0.217692798997219 no 750 0.201923739628713 932 2876596 SGTC_1505 k297-0037 20.6 µM 0.834699348781135 0.217712243746043 no 751 0.201943504209702 971 4089396 SGTC_470 aa-861 153 µM 0.833131253983171 0.218146908014826 no 752 0.202385354328849 991 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1694 st024011 44.9 µM 0.832792570620864 0.218240854170352 no 753 0.202480862740914 1051 2787533 SGTC_1811 st050069 61.5 µM 0.832710766129437 0.218263549117886 no 754 0.202503935575779 1011 3877702 SGTC_1643 st009866 20.2 µM 0.832130555536661 0.218424555448336 no 755 0.202667628214102 1012 3156273 YOR207C RET1 SGTC_2110 5483698 200 µM 0.831289839047144 0.218657972543645 no 756 0.202904956658613 1000 2848765 YHR062C RPP1 SGTC_1937 st074714 47.2 µM 0.831146093379803 0.218697896556682 no 757 0.202945551676699 1016 17250970 SGTC_1302 1159-0335 255 µM 0.830315386353035 0.21892869982272 no 758 0.203180245516282 967 649284 SGTC_3077 9117319 49.47 µM 0.829295282976225 0.219212316470694 no 759 0.203468669700247 1004 17154678 SGTC_1023 4482-3888 16 µM 0.82562244738436 0.220235212738847 no 760 0.2045091487245 1005 3303168 SGTC_2152 5568786 200 µM 0.823581429864518 0.220804823582293 no 761 0.205088715554322 988 5399883 SGTC_1898 st060199 18.6 µM 0.821134564535845 0.221488809757324 no 762 0.205784811897532 1029 688866 SGTC_1880 MG-132 525 µM 0.8207576753396 0.221594271282244 no 763 0.20589215566172 962 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3121 9125696 49.47 µM 0.820600319001146 0.221638311386712 no 764 0.205936982963273 1048 1235365 SGTC_2003 4023581 200 µM 0.819654319182392 0.221903178479342 no 765 0.206206599151419 993 16641307 SGTC_2258 7960471 200 µM 0.816546157953323 0.222774692891058 no 766 0.207093917585541 924 2974708 SGTC_1861 st057647 17.4 µM 0.815998031198435 0.222928587231719 no 767 0.207250630876115 1026 688668 SGTC_2904 7225135 42.03 µM 0.812317327773807 0.223963564174557 no 768 0.208304785134758 1077 4446116 SGTC_905 2-aminofluorene 215 µM 0.811935074514661 0.224071206231051 no 769 0.208414443564706 1103 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1373 2887-0003 58.5 µM 0.811496409530844 0.22419476996608 no 770 0.208540326983133 989 776948 SGTC_2007 4011539 71.82 µM 0.81079339390032 0.22439287701523 no 771 0.208742164410744 999 45595301 SGTC_554 4483-2211 187 µM 0.809930912424752 0.224636056579246 no 772 0.208989942047405 979 747107 SGTC_1067 clotrimazole 1.36 µM 0.80959084582326 0.224731980581411 no 773 0.209087685538523 1044 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1707 st032323 6.317 µM 0.806747816397718 0.225534834045431 no 774 0.209905894679815 1000 3132057 YMR211W DML1 SGTC_772 k072-0172 35.3 µM 0.806010040199283 0.225743442337355 no 775 0.210118529980598 979 5861980 SGTC_3029 9088683 49.47 µM 0.805482032926629 0.225892804861894 no 776 0.210270785199207 1057 25236615 SGTC_2845 9003024 42.97 µM 0.805445305066287 0.225903196505365 no 777 0.210281378387812 1045 2990173 SGTC_698 k064-0052 127 µM 0.805275885524776 0.225951134936091 no 778 0.210330247070472 1050 5088751 SGTC_2768 sulfasalazine 50.2 µM 0.80440614983653 0.226197323195372 no 779 0.21058122532065 1057 5384001 An antioxidant and salicylic acid derivative. SGTC_1534 6-azauridine 81.6 µM 0.803523211007206 0.226447403708139 no 780 0.210836193250987 1100 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3172 9105863 49.47 µM 0.803067538773945 0.226576527775775 no 781 0.210967849387663 1016 2348785 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.801879924100691 0.226913257990667 no 782 0.211311210088051 1064 23847180 SGTC_1239 0337-0584 35.4 µM 0.801652538066814 0.226977762048104 no 783 0.211376988788481 1081 914301 YML130C ERO1 SGTC_2832 7992762 51.95 µM 0.801415639806372 0.227044975496999 no 784 0.211445531959885 923 2985177 SGTC_2256 7954252 200 µM 0.797655794676715 0.228113230757677 no 785 0.212535131615526 920 2972920 SGTC_1268 0828-0275 2.46 µM 0.79626045221955 0.228510396375048 no 786 0.212940333517009 1075 745337 SGTC_595 3909-8003 73.7 µM 0.796222696571128 0.228521148411719 no 787 0.212951303867634 1051 699517 SGTC_178 4092-0806 87.505 µM 0.795333934973995 0.228774331611242 no 788 0.213209639314132 1031 2169044 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.794200784830919 0.229097362495137 no 789 0.213539275849442 1089 16623 A steroid. SGTC_3330 9141424 71.43 µM 0.794130539333807 0.229117396031238 no 790 0.213559720231432 1069 27261020 SGTC_87 0100-0052 35.5 µM 0.79403385763633 0.229144970597974 no 791 0.213587860520132 1170 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1853 st056710 91.2 µM 0.793730691260607 0.229231448684528 no 792 0.213676114490265 1108 269167 SGTC_2793 7325131 81.82 µM 0.793207119786023 0.229380840321373 no 793 0.213828580024227 1012 4176441 SGTC_726 3448-4391 34.2 µM 0.792586508126124 0.229557991277473 no 794 0.214009385967949 1085 1356692 SGTC_3035 9091303 49.47 µM 0.79219972284295 0.229668436251461 no 795 0.214122115085942 1051 25237002 SGTC_2312 7706453 155.7 µM 0.790266983426082 0.230220767894966 no 796 0.214685932216056 1020 976098 SGTC_991 3996-0057 64.7 µM 0.790132476403892 0.230259234482936 no 797 0.214725202577288 1002 715343 SGTC_1929 genistein trimethyl ether 50.5 µM 0.789905276521566 0.230324217724017 no 798 0.21479154481224 1089 136420 SGTC_587 k089-0003 57 µM 0.789638377752591 0.230400568656385 no 799 0.214869494309059 988 9659696 SGTC_590 k048-0076 22.4 µM 0.788729232442082 0.230660751298749 no 800 0.215135139315083 1029 6832814 SGTC_2867 9039098 71.43 µM 0.788359736020303 0.23076654207886 no 801 0.215243157686592 1032 6463460 SGTC_1175 0741-0056 27.6 µM 0.78757635033449 0.230990923398303 no 802 0.215472276289877 1125 765927 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.786724071415935 0.231235175735303 no 803 0.215721704857103 1126 5024745 SGTC_2321 7390090 138.78 µM 0.785645930250296 0.231544363648473 no 804 0.216037474103796 1004 649046 SGTC_2272 7805186 180 µM 0.784375620553188 0.231908956949743 no 805 0.216409869613631 1061 2956062 YPR165W RHO1 SGTC_3154 9100113 49.47 µM 0.783865925603025 0.232055335015865 no 806 0.216559392755965 1075 25237525 SGTC_2987 9018338 71.43 µM 0.783393486557115 0.232191059569764 no 807 0.216698039936998 1066 5055682 SGTC_2511 berberine 10.47 µM 0.782224267737642 0.232527148241788 no 808 0.217041392467406 1027 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3291 9121177 71.43 µM 0.781601565376267 0.232706252625163 no 809 0.217224383328095 977 17015612 SGTC_2058 5236698 133 µM 0.781176059597117 0.232828682546323 no 810 0.21734947611481 1034 766665 SGTC_297 0986-0032 24 µM 0.780809133668431 0.232934286135236 no 811 0.217457380632984 1056 2847425 SGTC_2526 patulin 37.61 µM 0.780759721779941 0.232948509219731 no 812 0.21747191390087 1083 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2136 5328288 199.296 µM 0.780588585634227 0.232997774045679 no 813 0.217522253640258 985 262395 SGTC_3335 9143315 29.6265 µM 0.77963294337229 0.233272980364211 no 814 0.21780347966077 1037 4899691 SGTC_641 4092-0595 30 µM 0.777551539023504 0.233873008063081 no 815 0.218416719779002 1078 786260 SGTC_1296 1068-0102 11.9 µM 0.776920411485433 0.234055118479746 no 816 0.21860286396041 1045 767053 SGTC_1160 4092-0570 10.5 µM 0.776276421130353 0.234241021360546 no 817 0.218792895994655 1054 4994975 SGTC_1747 st037496 66.6 µM 0.774799505381538 0.234667676171514 no 818 0.219229070804563 1087 723305 SGTC_2553 4-methylesculetin 85.09 µM 0.773061223323335 0.235170385133576 no 819 0.219743074211381 1119 5319502 SGTC_3003 9075612 71.4286 µM 0.771922960612634 0.235499891219547 no 820 0.22008002869911 1050 6501993 SGTC_1151 3909-8316 15.3 µM 0.770139953472715 0.236016550606243 no 821 0.220608439113371 1072 800431 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.770092847923737 0.236030208776016 no 822 0.220622409119866 1117 688751 SGTC_1250 0485-0349 40.2 µM 0.76999689656519 0.236058031048034 no 823 0.220650866806236 1067 6842794 YDL195W SEC31 SGTC_2506 ethyl hematommate 54.16 µM 0.76917851851267 0.236295403206109 no 824 0.220893670490309 1030 3940691 An allergen. SGTC_787 4152-0075 138 µM 0.768950571379037 0.236361543113996 no 825 0.220961327100456 1050 9566539 SGTC_949 1165-0505 146 µM 0.767642437336686 0.23674130121815 no 826 0.221349821472724 1105 6244267 SGTC_989 1501-0895 10.3 µM 0.767296278977139 0.236841848907415 no 827 0.221452690151742 1091 2830112 SGTC_2206 7254556 146.969 µM 0.765606738913291 0.237332941899133 no 828 0.221955166755545 1089 4398905 SGTC_3320 9137005 35.139 µM 0.762361668010084 0.238277742288698 no 829 0.222922088756589 1028 4908713 SGTC_950 1165-0508 94.1 µM 0.762257003876351 0.238308249445071 no 830 0.22295331504139 1061 6148369 SGTC_681 1642-0006 26.6 µM 0.761333481047759 0.238577527531439 no 831 0.22322895374827 1110 4446530 SGTC_32 0928-0142 34.1 µM 0.759178595867454 0.239206489803043 no 832 0.223872864082377 1085 2244242 SGTC_2314 7727897 200 µM 0.759016294160191 0.239253898665706 no 833 0.223921404849031 1110 900724 SGTC_68 0986-0284 82.829 µM 0.75882118055076 0.239310898787601 no 834 0.223979766828571 966 423278 YIL048W NEO1 SGTC_1701 st028638 40.4 µM 0.75839918463233 0.239434205248331 no 835 0.224106022930753 1100 3490878 SGTC_891 0929-0073 133 µM 0.755508702965132 0.240279730882472 no 836 0.224971906207996 1115 5603632 SGTC_3316 9136639 10.545 µM 0.755034262443644 0.24041866981135 no 837 0.225114212286001 1090 4903665 SGTC_2934 9036370 36.88 µM 0.754515615503751 0.240570604549729 no 838 0.225269836192308 1118 6462800 SGTC_279 1273-0055 2.93 µM 0.752584854900242 0.241136669396379 no 839 0.225849710703738 1170 2847562 SGTC_2029 5175081 200 µM 0.752241011739777 0.241237554030578 no 840 0.225953067234832 1147 1380876 SGTC_81 0411-0046 9.971 µM 0.75208856504121 0.241282289696429 no 841 0.225998900060373 1013 12925265 SGTC_1437 4092-1038 11.6 µM 0.751751224078562 0.241381298828303 no 842 0.226100339693932 1129 3977136 SGTC_3235 9132602 49.47 µM 0.75109171019239 0.241574929033223 no 843 0.226298732190776 1151 4912240 SGTC_1303 1160-0052 261 µM 0.750634796502469 0.241709126204791 no 844 0.22643623689941 1145 3562476 SGTC_1006 4099-6547 255 µM 0.750417062869406 0.241773089577957 no 845 0.226501778779524 1105 3146833 SGTC_935 2996-0153 430 µM 0.749125959005478 0.242152564426197 no 846 0.226890645092845 1126 23738523 SGTC_2243 6634756 200 µM 0.748223188391186 0.242418093999094 no 847 0.227162773254563 1100 885676 SGTC_1388 3346-4487 254 µM 0.748124033693621 0.242447267723502 no 848 0.227192673324598 1152 3345614 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.747376720924928 0.242667206495105 no 849 0.227418096618361 1157 5393153 SGTC_573 3702-0553 84.7 µM 0.745323887425058 0.243271923606955 no 850 0.228037971908943 1099 1222756 SGTC_969 1313-0238 134 µM 0.739974115561774 0.244851662179998 no 851 0.229657850301175 1152 5212874 SGTC_2234 tolnaftate 200 µM 0.739808174513198 0.244900751179061 no 852 0.22970819909229 1102 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_224 benfluorex 43.875 µM 0.738623071579026 0.245251484522678 no 853 0.230067955258416 1129 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2912 7964298 10.93 µM 0.737835754163177 0.245484641738965 no 854 0.230307131720113 1161 2975850 SGTC_2147 5545932 89.7195 µM 0.736827890586288 0.245783285507705 no 855 0.230613509966655 1121 797404 SGTC_1484 3473-2379 286 µM 0.736337824060593 0.245928569370484 no 856 0.23076256647102 1259 671917 SGTC_1524 corynanthine 62.1 µM 0.736065368529077 0.246009360765447 no 857 0.230845458630852 1115 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_680 0417-1641 114 µM 0.735164917298362 0.246276473352921 no 858 0.231119531121881 1094 2835990 SGTC_2388 9080168 200 µM 0.734580142671695 0.2464500259163 no 859 0.231297617581759 1107 15943073 SGTC_2856 9022925 19.48 µM 0.734219065390895 0.246557221094941 no 860 0.231407617770845 1115 4944862 SGTC_1072 oxiconazole 14.9 nM 0.733128446911319 0.246881151147484 no 861 0.231740045699422 1126 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2170 morpholine 200 µM 0.732161211364955 0.247168625095941 no 862 0.232035088158882 1135 121171 Reacts with secondary amines. SGTC_2440 5628896 157.78 µM 0.731219651127802 0.247448639901418 no 863 0.232322499470718 1134 5522048 SGTC_1432 4049-0298 68.4 µM 0.73044618611006 0.247678790885689 no 864 0.2325587478062 1159 741646 SGTC_2712 st079126 47.7 µM 0.730329642269369 0.247713479388049 no 865 0.232594356710633 1125 3152970 SGTC_723 4182-0001 115 µM 0.729143358725397 0.248066716383343 no 866 0.232956987202162 1107 744821 YLR208W SEC13 SGTC_1454 4239-0054 42.6 µM 0.728850825077899 0.248153864758133 no 867 0.233046458938416 1185 1340767 SGTC_1347 1493-0251 600 nM 0.728518713981279 0.248252823396147 no 868 0.233148058605588 1149 3986378 SGTC_2564 betulinic acid 100 µM 0.726914564423775 0.248731105527051 no 869 0.233639147268304 1181 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_975 1335-0046 28.5 µM 0.72686869015632 0.24874479029419 no 870 0.233653199484024 1142 16486740 SGTC_2917 7979103 53.79 µM 0.724733784924064 0.249382097783391 no 871 0.234307682212223 1151 2980565 SGTC_2719 novobiocin 32.65 µM 0.723112842105646 0.249866557317051 no 872 0.234805280041178 1142 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_339 3091-4833 71.4 µM 0.722793209364273 0.249962146536067 no 873 0.234903469962858 1135 3240077 SGTC_523 1934-0222 13.7 µM 0.720803751357388 0.250557548966464 no 874 0.235515133519285 1172 1361595 SGTC_3053 9095903 49.47 µM 0.715607690860084 0.252116156416231 no 875 0.237116811687937 1212 17174018 SGTC_1578 josamycin 24.2 µM 0.715346340628389 0.252194685752912 no 876 0.237197530299647 1114 5282165 A P450 substrate. SGTC_320 4092-0846 5.34 µM 0.71468302739263 0.252394053019897 no 877 0.237402463851523 1144 1359356 SGTC_1428 4049-0204 61.7 µM 0.710597927634828 0.253623710805246 no 878 0.238666713835145 1203 X1428 SGTC_109 0132-0036 33.701 µM 0.709425912188938 0.253977079730535 no 879 0.239030106192335 1062 67274 A color developer. SGTC_2874 9043904 71.43 µM 0.709211090677847 0.254041877569558 no 880 0.239096746032539 1093 4463428 SGTC_2074 5212007 75.395 µM 0.708533574739819 0.254246297368748 no 881 0.239306984940805 1110 758611 SGTC_1204 4049-0315 18.3 µM 0.708365505268269 0.254297020560682 no 882 0.239359153943787 1160 588402 SGTC_1588 farnesol 29.9 µM 0.708077322323386 0.254384006219493 no 883 0.239448620795373 1188 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2214 7179297 48.276 µM 0.707829566980676 0.254458801602957 no 884 0.239525551429745 1171 769744 SGTC_1420 4'-methoxyflavone 42 µM 0.707036950972123 0.254698163506278 no 885 0.239771757636546 1178 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1335 1486-0900 202 µM 0.705461765738323 0.255174203045001 no 886 0.240261458876119 1198 X1335 SGTC_2727 riluzole 51.77 µM 0.704329368709411 0.255516714021372 no 887 0.240613840409092 1178 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3146 9095609 49.47 µM 0.70403618508336 0.255605431064119 no 888 0.240705119696252 1183 17173999 SGTC_3099 9120367 49.47 µM 0.700007834312297 0.25682603280832 no 889 0.241961205934951 1233 24824940 SGTC_387 norethindrone acetate 66.7 µM 0.699745332435302 0.256905676775456 no 890 0.242043180259405 1156 541197 SGTC_3078 9116413 49.47 µM 0.699466732039852 0.256990219143948 no 891 0.242130198316134 1151 17177322 SGTC_533 1222-0222 6.71 µM 0.697892159310463 0.257468301240597 no 892 0.242622319089921 1243 3982874 SGTC_1575 cyproterone acetate 48 µM 0.697808860375085 0.257493605871259 no 893 0.242648368615813 1155 9880 An androgen receptor antagonist and liver toxin. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.697677164938834 0.257533615073146 no 894 0.242689555949162 1195 7104 SGTC_258 haloperidol 50.781 µM 0.696902488220188 0.257769027958502 no 895 0.242931910249853 1170 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3198 9112019 49.47 µM 0.696622632838979 0.257854099356723 no 896 0.243019493993533 1227 45595555 SGTC_1463 k081-0032 34.1 µM 0.696534166718374 0.257880994621729 no 897 0.243047183967411 1042 977755 SGTC_1939 st074455 53.6 µM 0.696429891304452 0.257912698060384 no 898 0.243079824454981 1206 1644229 SGTC_820 1582-0060 59.9 µM 0.696070213996582 0.258022068283713 no 899 0.24319242951566 1179 3848840 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.6956005701078 0.258164913209749 no 900 0.243339504527273 1248 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_743 1275-0778 158 µM 0.695548609319623 0.258180719904952 no 901 0.243355779667798 1191 2849257 YMR203W TOM40 SGTC_460 trequinsin 123 µM 0.695360368019082 0.258237987919047 no 902 0.243414745469664 1234 5537 A vasodilator. SGTC_2210 7115885 190.385 µM 0.694975912000478 0.258354970126082 no 903 0.243535198692897 1212 2927039 SGTC_2572 astragaloside iv 100 µM 0.694529756709604 0.258490760591191 no 904 0.243675023154377 1187 45006101 An anti-inflammatory agent. SGTC_783 0848-0141 92.7 µM 0.692738233984829 0.259036395005444 no 905 0.244236920154388 1195 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1881 5652484 16 µM 0.692198578266438 0.259200871689533 no 906 0.244406315717728 1164 2255129 SGTC_227 fluconazole 33.516 µM 0.690685344174639 0.259662364078005 no 907 0.244881650730861 1178 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.68998396562437 0.259876407898108 no 908 0.245102135417498 1281 688664 SGTC_2471 5466956 24.79 µM 0.68974717654283 0.259948690761778 no 909 0.245176596306379 1158 724419 SGTC_651 3253-0966 34.4 µM 0.68913958370599 0.260134213593451 no 910 0.245367716086571 1233 781462 SGTC_2069 5228469 200 µM 0.68687398506667 0.260826594353667 no 911 0.24608107094153 1171 2835210 SGTC_2735 sertaconazole 140 nM 0.680615153240214 0.262744246500275 no 912 0.248057518040195 1267 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2370 9071495 200 µM 0.679373196590687 0.263125627052265 no 913 0.248450714250997 1176 21791103 SGTC_2085 5307070 144.047 µM 0.678918876623779 0.263265210438626 no 914 0.248594632225442 1186 2840351 SGTC_745 0469-0705 296 µM 0.678910086332865 0.263267911504114 no 915 0.248597417222557 1300 3486736 SGTC_3044 9093193 49.47 µM 0.67817884648111 0.263492655179483 no 916 0.248829151574025 1192 25236277 SGTC_830 4076-0286 57.8 µM 0.677534143802782 0.263690883189701 no 917 0.249033557119838 1264 6866659 SGTC_3355 9151058 44.0485 µM 0.677520834000953 0.263694976382126 no 918 0.249037777986433 1237 17015728 SGTC_1143 3454-2408 5.08 µM 0.677312803311885 0.263758956725941 no 919 0.249103754597743 1187 X1143 SGTC_1547 harmine 94.2 µM 0.67708793507956 0.263828124399804 no 920 0.249175081665847 1262 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1122 capsaicin 818.572 nM 0.675954517503812 0.264176895331382 no 921 0.249534761290487 1258 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_11 0438-0307 1.3 µM 0.675432433473423 0.264337628001284 no 922 0.24970053259866 1225 4011476 SGTC_1870 st057514 26.5 µM 0.67440243806565 0.264654875977838 no 923 0.250027746566533 1234 5393161 SGTC_2365 9042475 200 µM 0.674262517498283 0.264697987724009 no 924 0.250072214761184 1247 6464479 SGTC_1391 3442-0225 151 µM 0.673094542855824 0.265057998517567 no 925 0.250443572742901 1200 5227075 SGTC_2968 9090663 33.37 µM 0.67245803217957 0.265254298118023 no 926 0.250646074524042 1202 25236811 SGTC_1431 4049-0260 9.09 µM 0.672313829369573 0.265298780451122 no 927 0.250691963768214 1220 3854841 SGTC_1419 3993-2473 62.6 µM 0.670958952438595 0.265716905053154 no 928 0.25112333955588 1267 704026 SGTC_1908 st060353 56.5 µM 0.667864270843119 0.266673197130466 no 929 0.252110118055491 1274 4227716 SGTC_229 benomyl 22.8748 µM 0.667766615801554 0.266703401950473 no 930 0.252141289861051 1236 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1233 0325-0408 14.2 µM 0.667734625868174 0.266713296850776 no 931 0.252151501593429 1268 12874 SGTC_99 0109-0120 622.8 µM 0.667101491470742 0.26690917168363 no 932 0.252353653765896 1289 759414 SGTC_2020 4017018 200 µM 0.666973034843123 0.266948921591042 no 933 0.252394678839468 1254 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2016 5121758 140 µM 0.663906214476012 0.267898812365554 no 934 0.253375169278257 1236 2795203 SGTC_1298 1079-1278 263 µM 0.663640664774492 0.267981141476259 no 935 0.253460162023132 1269 2840950 SGTC_1195 1502-0147 41.1 µM 0.66363028677957 0.267984359253467 no 936 0.25346348394382 1252 817940 SGTC_2253 7938677 135.83 µM 0.65330402508493 0.271195705073765 no 937 0.256780149016435 1322 2301972 SGTC_1290 0986-0249 10.2 µM 0.649824618399828 0.272282064845383 no 938 0.257902757443566 1224 53329 SGTC_257 daunorubicin 18.5 µM 0.647319276732941 0.273065633365669 no 939 0.258712664039922 1309 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2302 7771753 200 µM 0.645732510969417 0.273562486329997 no 940 0.259226300969223 1247 2203047 SGTC_3243 9134147 49.47 µM 0.645350310716006 0.273682228872355 no 941 0.259350098114586 1321 24282180 SGTC_1998 st075797 76.8 µM 0.643097858155591 0.274388443807164 no 942 0.260080302106476 1273 24208315 SGTC_689 0833-0039 98 µM 0.641586743422008 0.274862729568108 no 943 0.260570771307879 1273 5374726 SGTC_1032 k061-1018 98.7 µM 0.640683396350087 0.275146451280546 no 944 0.260864201918724 1405 4005393 SGTC_2446 5162541 200 µM 0.640577562298317 0.275179700894812 no 945 0.260898590689461 1248 1549321 SGTC_630 4356-0227 183 µM 0.639147954054961 0.275629031026352 no 946 0.261363343173685 1309 779312 SGTC_3057 9095946 49.47 µM 0.638903888558967 0.27570577757336 no 947 0.261442729093225 1299 24540043 SGTC_2355 9061122 103.12 µM 0.636662951597402 0.276410932182278 no 948 0.262172205365197 1271 5302957 SGTC_835 0312-0010 67.2 µM 0.636594523689421 0.276432478270169 no 949 0.262194496613412 1255 1626196 SGTC_2171 5739187 198.077 µM 0.633613046903928 0.277372063189866 no 950 0.263166692058177 1234 2262761 SGTC_3192 9110362 49.47 µM 0.633180924081824 0.277508372160617 no 951 0.263307750664229 1358 16649480 SGTC_1412 3909-8563 178 µM 0.631834916748212 0.27793316686062 no 952 0.263747377490724 1359 23767530 SGTC_2732 terfenadine 20 µM 0.631223316614834 0.278126290300841 no 953 0.263947259179813 1290 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_707 0865-0008 204 µM 0.630822834417076 0.278252785012102 no 954 0.264078185630099 1313 723043 SGTC_165 k038-0023 64.381 µM 0.62997393937643 0.278521006323322 no 955 0.264355817475033 1272 46368543 SGTC_310 1273-0058 1.06 µM 0.629726898675091 0.278599086246781 no 956 0.264436640250136 1304 2734232 SGTC_1127 asiatic acid 681.4 nM 0.627614112440213 0.279267290603342 no 957 0.265128380758849 1290 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1393 3470-5649 58.2 µM 0.627381624471381 0.279340866391223 no 958 0.265204554984141 1249 4108395 SGTC_2427 5545055 42.75 µM 0.624988923928045 0.280098634358269 no 959 0.265989163795782 1339 5372858 SGTC_1622 st003707 19.4 µM 0.624421789170939 0.280278391809634 no 960 0.266175309553359 1339 10140899 SGTC_323 4013-0906 34.3 µM 0.623229646105582 0.280656432227804 no 961 0.266566811320553 1340 2910086 SGTC_961 1252-1571 372 µM 0.622995976813327 0.280730559986624 no 962 0.266643582823221 1351 6813498 SGTC_2757 clomiphene 4.22 µM 0.622912923238032 0.280756909654945 no 963 0.266670872574706 1362 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1498 4478-3555 97.6 µM 0.622326592822888 0.280942963504219 no 964 0.266863569237191 1288 3437919 SGTC_2850 9015429 58.44 µM 0.620410694574213 0.281551329791016 no 965 0.267493716616991 1307 6457570 SGTC_1713 st033146 12.748 µM 0.620205769637986 0.281616438394201 no 966 0.267561161725626 1351 674619 SGTC_3103 9120822 49.47 µM 0.619326826933582 0.281895777765096 no 967 0.267850537478796 1372 17141819 SGTC_1857 st056007 79.3 µM 0.617779668492797 0.282387808818358 no 968 0.268360293697302 1315 619834 SGTC_334 1502-1024 68.5 µM 0.617740422860926 0.28240029517918 no 969 0.268373230651439 1332 3296216 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.616617794030008 0.282757582328468 no 970 0.26874342746501 1295 15053 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.616516376329478 0.282789870155131 no 971 0.268776883480933 1306 115019 SGTC_521 r062-0005 13.8 µM 0.6163540911197 0.282841539738903 no 972 0.268830423029636 1269 2832033 SGTC_936 3005-4620 401 µM 0.615286742217984 0.283181483232447 no 973 0.269182685740729 1393 777207 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.613930687232298 0.283613660196817 no 974 0.269630565365053 1351 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2120 5538279 151.968 µM 0.61378114303198 0.283661339518101 no 975 0.269679979866238 1361 2058197 SGTC_2249 haloperidol 116.36 µM 0.611320416055855 0.284446446320984 no 976 0.270493738810132 1319 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1056 3448-1962 115 µM 0.60968509171885 0.284968777984529 no 977 0.271035216045474 1341 715507 SGTC_2684 capsaicin 100 µM 0.609033642012002 0.285176981966585 no 978 0.271251070041398 1311 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1267 0828-0272 9.49 µM 0.608016181499449 0.285502308330649 no 979 0.271588370891974 1395 745334 SGTC_2229 7354935 190 µM 0.607056070422953 0.285809459514846 no 980 0.271906851106677 1287 318112 SGTC_1203 3992-3522 103 µM 0.60644479709682 0.286005095109248 no 981 0.272109714459574 1557 5322312 SGTC_1455 4262-0120 131 µM 0.606388363484666 0.286023159670648 no 982 0.272128446882588 1396 1529587 SGTC_2764 methyldopa 94.69 µM 0.605627460968824 0.286266779678895 no 983 0.272381081414447 1381 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1184 1269-1718 139 µM 0.605527143213631 0.286298906008422 no 984 0.272414397563377 1394 5403821 SGTC_3298 9116858 71.43 µM 0.602312967260876 0.287329136946499 no 985 0.273482915399505 1397 2506942 SGTC_3134 9127454 49.47 µM 0.602259714692879 0.287346220605838 no 986 0.273500636092937 1412 24262820 SGTC_2095 5432005 200 µM 0.602070117365889 0.287407048167755 no 987 0.273563732426607 1332 783734 SGTC_1952 st077036 64.1 µM 0.601325381441482 0.287646036997861 no 988 0.273811643734538 1333 2937007 SGTC_2707 st078556 66.6 µM 0.596831944482961 0.289089988648064 no 989 0.275309793989484 1340 17250899 SGTC_3310 9130229 44.1445 µM 0.596433847181205 0.289218080160107 no 990 0.275442717321171 1389 7761258 SGTC_2621 lithochol-11-enic acid 100 µM 0.595037709060296 0.289667511320153 no 991 0.275909132451249 1362 6708711 SGTC_24 0417-1663 219 µM 0.594682624729451 0.289781868868643 no 992 0.276027819177254 1329 4329390 SGTC_1264 0783-0040 158 µM 0.593048035836492 0.290308573370011 no 993 0.276574502658237 1309 2855798 SGTC_779 1360-0071 233 µM 0.591974190965522 0.290654836278115 no 994 0.276933935572055 1475 7566 SGTC_768 0384-0033 77.3 µM 0.591271656597221 0.290881474037984 no 995 0.277169208664352 1328 3965305 YMR134W ERG29 SGTC_476 mead acid 10 µM 0.590634300713466 0.291087156634905 no 996 0.277382738577456 1380 5312531 An omega 9 fatty acid. SGTC_1791 st048313 56.1 µM 0.5899201127563 0.291317714562133 no 997 0.277622104643105 1315 1204976 SGTC_2219 9098279 200 µM 0.589856359583704 0.29133829984071 no 998 0.277643476957191 1356 902349 SGTC_1728 st035614 33.7865 µM 0.589805854461835 0.291354607934585 no 999 0.277660408627544 1411 15945546 SGTC_1236 0330-0013 258 µM 0.58948010580994 0.291459802342578 no 1000 0.277769626871596 1331 4617066 SGTC_450 aminopyrene 156 nM 0.588832528817646 0.2916689777689 no 1001 0.277986811228923 1359 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1704 st028805 70.8 µM 0.587557079114401 0.292081168399024 no 1002 0.27841481369721 1348 2876101 SGTC_628 1636-0253 16 µM 0.586646849756901 0.292375495445213 no 1003 0.278720455456489 1357 4456143 SGTC_439 amiodarone 34.4 µM 0.586550618656162 0.292406620293989 no 1004 0.27875277800319 1356 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1416 3966-0321 25.3 µM 0.586077585273276 0.292559639923799 no 1005 0.278911689164238 1351 582530 YLR208W SEC13 SGTC_2163 5671233 125 µM 0.585086486226118 0.292880367086816 no 1006 0.279244782505776 1458 701023 SGTC_3115 9123671 49.47 µM 0.584211264891405 0.29316373096471 no 1007 0.279539091760194 1426 3286988 SGTC_139 0099-0334 718.624 µM 0.58317244984437 0.293500225249521 no 1008 0.279888607749485 1375 97690 SGTC_1328 1441-0025 69.2 µM 0.583029648281545 0.293546495694111 no 1009 0.279936670816446 1277 4562601 SGTC_3187 9109394 49.47 µM 0.582901532897999 0.29358801040945 no 1010 0.279979794326197 1288 17098090 SGTC_27 0485-0001 32.618 µM 0.581785105165066 0.293949894454717 no 1011 0.280355719043954 1325 2054479 SGTC_732 3970-1727 52.7 µM 0.580843198110178 0.294255368887927 no 1012 0.280673068950964 1426 1275699 SGTC_3184 9108758 49.47 µM 0.580676697923898 0.294309382616343 no 1013 0.280729184718576 1372 902885 SGTC_2522 biochanin a 4.94 µM 0.579296156929671 0.294757415246822 no 1014 0.281194679093281 1368 5280373 A possible chelator. SGTC_549 1661-1316 519 µM 0.578203507991093 0.295112239885174 no 1015 0.28156336533737 1425 2857282 SGTC_1989 st071868 50.2 µM 0.578070816333864 0.295155343300215 no 1016 0.281608154591484 1392 16414057 SGTC_1646 st011709 75.6 µM 0.578009778264004 0.295175171814452 no 1017 0.281628758770903 1357 5757843 SGTC_2894 9048625 32.47 µM 0.577605417961425 0.295306545714628 no 1018 0.281765274108357 1466 4092861 SGTC_1370 2001-0092 44.6 µM 0.577301910731709 0.295405170814926 no 1019 0.281867761576426 1517 790957 SGTC_2678 equilin 100 µM 0.575875380307911 0.295868926730753 no 1020 0.282349708829753 1449 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_45 0kpi-0036 14.9 µM 0.575792507067509 0.295895878565012 no 1021 0.282377719382349 1391 2795021 SGTC_1237 0330-0133 46.1 µM 0.575470454432283 0.296000626444547 no 1022 0.282486583519729 1348 X1237 YHR072W ERG7 SGTC_3265 9137266 49.47 µM 0.57346657675712 0.296652771409873 no 1023 0.283164411633981 1361 17224265 SGTC_1365 1672-3266 55.4 µM 0.572979341213079 0.296811437474341 no 1024 0.283329340926074 1378 6415873 SGTC_1793 st048256 72.231 µM 0.571873555405101 0.297171675688103 no 1025 0.283703820370286 1314 672022 SGTC_3223 9129970 49.47 µM 0.570900435483134 0.297488859810531 no 1026 0.284033567871992 1445 17248386 SGTC_555 4296-0685 37 µM 0.57053842044988 0.297606896442923 no 1027 0.284156285605626 1398 2908540 YHR072W ERG7 SGTC_1889 st059080 5.18 µM 0.57033252473359 0.29767403920343 no 1028 0.284226092512723 1408 176925 Isolated from Daphnopsis sellowiana. SGTC_1392 3455-1037 33.9 µM 0.568747986648397 0.298190989484768 no 1029 0.284763588642535 1415 981132 SGTC_1782 st039423 80.636 µM 0.568197411395317 0.298370708502983 no 1030 0.284950464493877 1343 2068169 SGTC_2244 6635614 200 µM 0.568179040537289 0.298376705976475 no 1031 0.284956700925372 1365 836499 SGTC_176 1486-1328 72.834 µM 0.567095780755565 0.298730451193043 no 1032 0.285324554663796 1359 22310231 SGTC_101 0490-5701 117.494 µM 0.565264792537397 0.299328804803181 no 1033 0.28594683607711 1339 4661669 SGTC_3317 9138495 8.753 µM 0.564450033007706 0.299595236936929 no 1034 0.286223948286909 1379 17020139 SGTC_2842 9000675 19.48 µM 0.564194616235205 0.299678782148591 no 1035 0.286310845697552 1332 2989072 SGTC_2301 7769476 200 µM 0.563171181172398 0.300013647103215 no 1036 0.286659162420318 1451 977820 SGTC_2340 7987427 183.45 µM 0.561653324223427 0.300510596928141 no 1037 0.287176120789362 1421 2239331 SGTC_2540 epiandrosterone 100 µM 0.559786034221354 0.30112246137625 no 1038 0.287812695348154 1435 441302 A steroid. SGTC_1266 0828-0227 32.9 µM 0.557785242279969 0.301778693361853 no 1039 0.288495520624689 1421 3913820 SGTC_2372 9071633 200 µM 0.557752147253171 0.301789553474222 no 1040 0.28850682162824 1425 21321366 SGTC_3123 9126162 49.47 µM 0.557560201406186 0.301852543847819 no 1041 0.288572369749371 1437 25239884 SGTC_1149 3909-7961 23.3 µM 0.557503945684473 0.301871006262457 no 1042 0.288591582001657 1351 735261 SGTC_676 falcarinol 140 µM 0.557365180723131 0.301916549332897 no 1043 0.288638975089711 1513 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1904 st060225 78 µM 0.556471917276766 0.302209794902811 no 1044 0.288944143521284 1360 66595 SGTC_1395 3486-0190 4.35 µM 0.555341466273701 0.302581088875009 no 1045 0.289330560582195 1494 6748079 SGTC_860 0443-0016 25.1 µM 0.554428993455395 0.302880937453281 no 1046 0.289642644129092 1410 5337942 SGTC_207 4185-0010 4.486 µM 0.552667130636393 0.303460280955641 no 1047 0.290245682360534 1449 3761753 SGTC_375 3970-0961 9.27 µM 0.552260265130381 0.303594138591937 no 1048 0.290385025019506 1422 2898222 SGTC_3140 9094243 49.47 µM 0.550433976092144 0.30419530714723 no 1049 0.291010875119392 1402 19291112 SGTC_2612 dictamnine 15.46 µM 0.55030720998415 0.30423705504729 no 1050 0.291054339913983 1421 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1519 esterone 74 µM 0.549242645296445 0.304587748939367 no 1051 0.291419471007332 1354 698 A steroid. SGTC_1358 1509-0022 2.48 µM 0.548741030070317 0.304753055682703 no 1052 0.291591592190929 1414 3258434 SGTC_156 3474-0145 5.642 µM 0.547201517538234 0.305260649186369 no 1053 0.292120146862652 1389 2265471 SGTC_2162 5663267 200 µM 0.547020061091073 0.305320501994357 no 1054 0.29218247494114 1447 6456493 SGTC_1010 4112-3296 15.2 µM 0.546874767335337 0.305368430411031 no 1055 0.292232386036198 1464 704384 SGTC_31 0508-1974 57.237 µM 0.54613708443209 0.305611823187551 no 1056 0.292485854940302 1411 6810525 SGTC_230 MPP+ 141.667 µM 0.542555146374741 0.306794875929285 no 1057 0.29371806426201 1360 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_361 000s-0510 1.45 µM 0.542278314205584 0.306886392896715 no 1058 0.293813396205659 1417 660 SGTC_2563 tomatine 8.54 µM 0.540894489331089 0.307344047036957 no 1059 0.294290154712404 1506 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_294 k038-0071 157 µM 0.540519566038632 0.307468092176037 no 1060 0.294419385630822 1429 24152826 SGTC_1887 st057648 70.8 µM 0.538640921650347 0.308089981945908 no 1061 0.29506732275979 1515 688672 SGTC_2143 5623677 140.463 µM 0.536712996272476 0.308728758624832 no 1062 0.295732938721794 1414 5375313 SGTC_3301 9125354 19.7965 µM 0.533210502207017 0.309890715731663 no 1063 0.296943936185529 1410 41905162 SGTC_1957 st077035 62.4 µM 0.533099805907927 0.309927470437329 no 1064 0.296982246710603 1492 705593 SGTC_2610 ononetin 44.17 µM 0.53067239011382 0.310733927053428 no 1065 0.29782291099272 1409 259632 SGTC_1963 st076565 50.3 µM 0.529328756813442 0.311180711895151 no 1066 0.298288705120505 1446 4914280 SGTC_1752 st044819 83.042 µM 0.528657152937665 0.311404137947261 no 1067 0.298521652683393 1360 441209 YML126C ERG13 SGTC_3007 9078383 71.4286 µM 0.525461773819405 0.312468112386847 no 1068 0.29963111007701 1449 6496995 SGTC_873 0591-4978 488 µM 0.521872680699578 0.313665049358705 no 1069 0.300879490378797 1598 3305145 SGTC_497 capsazepine 133 µM 0.521547049748225 0.313773742331409 no 1070 0.300992869307588 1385 2733484 A calcium channel blocker. SGTC_2816 7982706 58.44 µM 0.521140346264757 0.313909519360492 no 1071 0.301134503300321 1426 2981853 SGTC_2569 tetrandrine 100 µM 0.520512611969289 0.314119136482901 no 1072 0.301353169928597 1400 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2014 4013930 200 µM 0.520357901919942 0.314170807484896 no 1073 0.301407073015835 1421 64556 SGTC_663 1486-0733 13.9 µM 0.51956961201913 0.314434141878616 no 1074 0.301681791316177 1444 722445 YPR165W RHO1 SGTC_2462 5162487 171.77 µM 0.519477601174001 0.314464884977549 no 1075 0.301713864347444 1433 2259986 SGTC_2013 4024628 200 µM 0.517265361600202 0.315204435888334 no 1076 0.30248546527605 1479 5230760 SGTC_1252 0493-0875 34.8 µM 0.516967910025921 0.315303930439252 no 1077 0.302589280029368 1441 3960963 SGTC_2128 5255449 168.493 µM 0.516803216780423 0.315359024430925 no 1078 0.302646767139355 1411 736008 SGTC_2673 kobusone 100 µM 0.515810037298881 0.315691354700226 no 1079 0.302993545749274 1516 6710676 An epoxy ketone and protein crosslinker. SGTC_2984 9022109 38.96 µM 0.514969977726373 0.315972565527944 no 1080 0.303286999727676 1495 6459207 SGTC_1289 0976-0073 69.1 µM 0.514288472134988 0.316200778516096 no 1081 0.303525160102044 1497 3391136 SGTC_97 0535-0701 19.132 µM 0.513448149640486 0.316482270285509 no 1082 0.30381893589425 1398 2832013 YGL099W LSG1 SGTC_2760 etidronate 98.04 µM 0.512386557197976 0.316838035228685 no 1083 0.304190248640945 1417 3305 A chelator and antioxidant. SGTC_1304 1165-0502 251 µM 0.512204445731301 0.31689908215962 no 1084 0.304253966002621 1485 767425 SGTC_861 0443-0273 110 µM 0.510618170910067 0.317431039753762 no 1085 0.304809224792359 1486 6149169 SGTC_3159 9100096 49.47 µM 0.510167415894613 0.317582269427791 no 1086 0.304967088973085 1392 25236875 SGTC_1167 k781-0610 148 µM 0.509628153924177 0.317763233453202 no 1087 0.305155997906589 1478 4525169 SGTC_981 1488-1094 54.9 µM 0.508253687350183 0.318224669940808 no 1088 0.305637722210473 1427 3449522 SGTC_1486 3970-0793 4.53 µM 0.507370012719181 0.31852148666365 no 1089 0.305947611138175 1522 2844330 SGTC_2600 tangeritin 87.95 µM 0.507097280254022 0.31861311807677 no 1090 0.306043281620576 1397 68077 A bioactive flavone. SGTC_842 0271-0008 11.1 µM 0.507045839050934 0.318630402301896 no 1091 0.306061327911077 1532 1221709 SGTC_3283 9109332 35.8195 µM 0.505892285675051 0.319018099396865 no 1092 0.306466134064714 1419 17027281 SGTC_1786 berberine 21.6 µM 0.505868117841523 0.319026224070029 no 1093 0.306474617594686 1425 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_163 TUB2.036 7.546 µM 0.505440284394872 0.319170066284892 no 1094 0.306624815283537 1489 15992207 YJR013W GPI14 SGTC_1757 st041620 31.8375 µM 0.505371739292726 0.319193114418031 no 1095 0.306648882143824 1441 5289815 SGTC_2679 rapamycin 1 nM 0.503835061325113 0.319710002168156 no 1096 0.307188643602703 1466 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1745 st081495 74 µM 0.503055155249803 0.319972470930216 no 1097 0.307462747289977 1475 13842402 YBL026W LSM2 SGTC_378 3970-0959 8.33 µM 0.501973642666008 0.320336591181754 no 1098 0.307843030760855 1488 6615653 SGTC_1561 5-methoxyflavone 52.9 µM 0.501730215741488 0.320418571262061 no 1099 0.307928653473138 1458 94525 SGTC_2955 9076254 12.21 µM 0.500774917088279 0.320740376527956 no 1100 0.308264770162057 1497 16459619 SGTC_2409 alverine citrate 63.97 µM 0.500589451782865 0.320802868651423 no 1101 0.308330043782026 1609 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1325 1431-0015 227 µM 0.499687857112935 0.321106731293997 no 1102 0.308647441987891 1394 1103340 SGTC_3353 9151644 39.2805 µM 0.498860574672272 0.321385654063151 no 1103 0.308938805081912 1475 4909158 SGTC_2051 5263410 176 µM 0.497938491765559 0.321696658059372 no 1104 0.309263697963484 1500 227584 SGTC_1202 1988-0068 29.6 µM 0.496190353455305 0.322286620451729 no 1105 0.30988005816093 1429 2850480 SGTC_356 1634-0012 32.5 µM 0.494269856090509 0.322935267028671 no 1106 0.310557805388755 1526 735457 SGTC_508 roscovitine 141 µM 0.493795025866888 0.323095723763502 no 1107 0.310725473206974 1547 160355 A CDKinase inhibitor. SGTC_380 3970-0968 6 µM 0.492667793449615 0.323476774953623 no 1108 0.311123668883601 1446 2891601 SGTC_2671 danthron 100 µM 0.491998453162058 0.323703127325572 no 1109 0.311360218524113 1477 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1465 k213-0056 144 µM 0.491493158074279 0.323874047363672 no 1110 0.311538845032548 1463 24048857 YMR208W ERG12 SGTC_3222 9128301 49.47 µM 0.490714409046416 0.324137538076907 no 1111 0.311814226917327 1491 4911358 SGTC_986 1493-0483 84 µM 0.489812412770196 0.324442839785216 no 1112 0.312133323149869 1500 40079 SGTC_2988 9073640 71.4286 µM 0.489262738110796 0.3246289479102 no 1113 0.312327848893671 1537 9102229 SGTC_1966 st070145 16.1 µM 0.486563362010404 0.325543534046822 no 1114 0.313283896409546 1445 3748532 SGTC_878 0828-0289 13.7 µM 0.486546991958919 0.325549083660374 no 1115 0.313289698086659 1494 745350 YLR208W SEC13 SGTC_2733 amorolfine 100 µM 0.485283904237615 0.325977399740528 no 1116 0.313737485716424 1558 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1826 st055655 41.6 µM 0.485217038830688 0.326000080368006 no 1117 0.313761198379292 1510 676168 SGTC_3312 9133330 71.43 µM 0.485198320829982 0.326006429595995 no 1118 0.313767836533114 1576 17617324 SGTC_1462 k081-0014 26.5 µM 0.484448762199487 0.326260724615113 no 1119 0.314033709614246 1368 3270634 SGTC_1356 1502-0781 85.8 µM 0.484325193777877 0.326302654158414 no 1120 0.314077549372041 1489 567702 SGTC_1081 sertraline 6 µM 0.483473383407331 0.326591752269896 no 1121 0.314379827067169 1574 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2064 5220758 200 µM 0.480823775012172 0.327491675000362 no 1122 0.315320875632608 1547 788518 SGTC_466 geldanamycin 89.2 µM 0.480416959396627 0.327629936326186 no 1123 0.315465468725638 1480 5288382 HSP90 inhibitor. SGTC_2231 micatex 6.853 µM 0.478580113900865 0.328254505119023 no 1124 0.316118684108005 1535 20737 An antifungal of unknown mechanism. SGTC_2517 totarol 10 µM 0.477951486446702 0.328468363017566 no 1125 0.31634236739741 1449 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3309 9129340 25.759 µM 0.477258747886375 0.32870409649533 no 1126 0.316588941063624 1585 17158987 SGTC_419 nsc-638432 893 µM 0.476777466887418 0.32886791277325 no 1127 0.316760296439056 1513 368090 SGTC_1657 st012939 43.4 µM 0.476665623523301 0.328905986227782 no 1128 0.316800122803187 1579 24207257 SGTC_302 1094-0063 18.9 µM 0.475612069748412 0.329264721607315 no 1129 0.317175387489204 1469 5440289 SGTC_881 0833-0569 170 µM 0.475312055644518 0.329366905279449 no 1130 0.317282283752671 1464 5418700 SGTC_34 0469-0683 81.75 µM 0.473753480702339 0.329897954972043 no 1131 0.317837855577578 1584 3690923 SGTC_534 k292-0788 63.4 µM 0.469746569967154 0.331264793000398 no 1132 0.319268045799413 1611 4146317 SGTC_1943 st076331 65.2 µM 0.469010684770047 0.331516063480226 no 1133 0.319530999356 1561 24208415 SGTC_2240 6690706 185.951 µM 0.468508294336242 0.331687649959479 no 1134 0.319710570469156 1441 805876 SGTC_254 nsc-64875 3.808 µM 0.466249915919182 0.332459412562139 no 1135 0.320518311908829 1641 56993 SGTC_1554 st069299 38.7 µM 0.466231275340008 0.332465785626628 no 1136 0.320524982524769 1523 24207999 SGTC_896 0964-0007 44.5 µM 0.465755935530512 0.33262831685411 no 1137 0.320695104618205 1536 6756758 SGTC_1068 loratadine 26.9 µM 0.465516456513409 0.332710212972787 no 1138 0.320780827409512 1503 3957 A H1 histamine antagonist. SGTC_563 tetrahydrosecaminediol 614 µM 0.462795171520637 0.333641387587559 no 1139 0.321755596279445 1630 334274 A psychoactive constituent of the cannabis plant. SGTC_3070 9117005 49.47 µM 0.462489831820913 0.333745933427786 no 1140 0.321865046227348 1603 8779016 SGTC_308 4092-1169 104 µM 0.4614392522356 0.334105741943019 no 1141 0.322241747724264 1548 2268590 YDL196W YDL196W SGTC_2872 9044037 25.97 µM 0.458832285606295 0.334999249067852 no 1142 0.323177304088312 1634 6465195 SGTC_1348 1493-0373 93.8 µM 0.458193683504182 0.335218265137225 no 1143 0.32340664875045 1574 3010129 SGTC_251 melphalan 456.522 µM 0.457837211585181 0.335340545728311 no 1144 0.323534699652314 1629 460612 A DNA alkylator. SGTC_1682 st012968 530 nM 0.457611478894961 0.335417987854394 no 1145 0.323615797562271 1482 24207270 SGTC_875 0709-0210 25.7 µM 0.457438798509393 0.335477234044853 no 1146 0.323677841278874 1588 6251364 SGTC_105 0111-0055 734.78 µM 0.456154031312035 0.335918162694137 no 1147 0.324139609344041 1529 5179370 SGTC_1848 st056003 16.4 µM 0.456153400301169 0.335918379310927 no 1148 0.324139836207071 1569 146492 SGTC_2059 5238311 157 µM 0.45515987338767 0.336259510113374 no 1149 0.324497113103025 1517 703021 SGTC_2279 7948423 32.93 µM 0.455057308207778 0.336294733896927 no 1150 0.324534005225662 1688 1247112 SGTC_2227 7312221 64.1025 µM 0.454141904669112 0.336609172980914 no 1151 0.324863346997561 1573 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2970 9090938 41.86 µM 0.453608793566433 0.336792348132313 no 1152 0.325055211593043 1688 17217104 SGTC_1969 st069479 40.1 µM 0.453496397014175 0.336830972147109 no 1153 0.325095668595854 1623 3895485 SGTC_1597 7-benzyloxygramine 47.5 µM 0.447649192876033 0.338842673763874 no 1154 0.327203197301597 1526 260807 SGTC_432 NS 1619 61.3 µM 0.447471064430932 0.338904030541003 no 1155 0.327267487766091 1575 4552 A K+/calcium channel activator. SGTC_472 calcifediol 10 µM 0.446217684062014 0.339335881228839 no 1156 0.327720005042543 1575 5283731 A vitamin D metabolite. SGTC_927 2425-1185 123 µM 0.445002733699802 0.339754692417861 no 1157 0.328158889283012 1502 730375 SGTC_1985 st071382 65.5 µM 0.444355245226047 0.339977972053988 no 1158 0.328392882644024 1550 6123237 SGTC_3108 9121785 49.47 µM 0.443679341031866 0.340211110446746 no 1159 0.328637216881737 1660 17140271 SGTC_1770 st043884 66.3 µM 0.443306425864 0.340339765551218 no 1160 0.32877205426111 1559 670149 SGTC_2180 6301957 200 µM 0.442518443957934 0.34061167909433 no 1161 0.329057043340398 1603 845462 SGTC_2536 dehydroabietamide 32.04 µM 0.442412281951479 0.340648319377821 no 1162 0.329095446508462 1682 3983547 SGTC_1049 3226-0134 66 µM 0.442314665459619 0.340682011627397 no 1163 0.329130760003909 1569 5702385 SGTC_1810 st050138 53 µM 0.441043835751758 0.341120753333626 no 1164 0.329590631186232 1624 3444541 SGTC_2729 fluphenazine 10.66 µM 0.439330892853485 0.341712470336866 no 1165 0.330210896352297 1498 3372 An atypical antipsychotic. SGTC_2306 7482397 179.52 µM 0.435682986259222 0.342973894268524 no 1166 0.331533375774186 1703 891448 SGTC_266 formosanin C 406 nM 0.435143115420292 0.343160727507209 no 1167 0.331729274754208 1578 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2211 7117706 200 µM 0.434780381974914 0.343286280303269 no 1168 0.331860923038724 1631 822771 SGTC_2514 salinomycin 42.74 µM 0.432949321433184 0.343920328435489 no 1169 0.332525793753306 1730 23682228 A polyether potassium ionophore. SGTC_1459 k035-0031 35.7 µM 0.428328957018975 0.34552218806599 no 1170 0.334205819783842 1476 3877128 YMR208W ERG12 SGTC_223 busulfan 5 mM 0.426773742917133 0.346061998463087 no 1171 0.334772066460202 1627 2478 A DNA alkylator. SGTC_3122 9126309 49.47 µM 0.426255657900016 0.34624189385014 no 1172 0.334960782493767 1598 17591206 SGTC_2849 9019321 12.99 µM 0.42563535326088 0.346457328739694 no 1173 0.33518678755133 1607 16489627 SGTC_1211 1056-0033 32.3 µM 0.425335833241316 0.346561371323103 no 1174 0.335295937621657 1647 6741922 SGTC_3191 9110352 49.47 µM 0.424703678830504 0.346780997232419 no 1175 0.335526350826958 1622 17122424 SGTC_2881 9058953 51.95 µM 0.424520042009056 0.346844806813105 no 1176 0.335593295992548 1507 17122249 SGTC_714 4296-0578 26.1 µM 0.423855272571254 0.347075835250852 no 1177 0.335835682632717 1672 1589775 SGTC_3041 9091929 49.47 µM 0.423351012473559 0.347251119531457 no 1178 0.336019590304656 1634 25236887 SGTC_231 b-estradiol 524 µM 0.423098858304918 0.347338782314328 no 1179 0.336111567665816 1541 450 A steroid. SGTC_1755 st041960 45.185 µM 0.423086696155028 0.347343010759093 no 1180 0.336116004257216 1605 2257073 SGTC_3088 9117578 49.47 µM 0.42138323506782 0.347935444773721 no 1181 0.336737629606139 1614 678341 SGTC_906 1165-0455 526 µM 0.420823966100866 0.348130029808751 no 1182 0.336941814892815 1554 3252859 SGTC_484 loperamide 105 µM 0.420641189038774 0.348193631641856 no 1183 0.33700855597479 1598 3955 An opioid-receptor agonist. SGTC_1291 0993-0025 5.79 µM 0.419184583031206 0.348700646466256 no 1184 0.337540619204013 1685 4353356 SGTC_552 k242-0005 476 µM 0.419041253885479 0.348750551040812 no 1185 0.337592991479137 1614 4088318 SGTC_1640 st009078 66.4 µM 0.417141084691761 0.349412402067363 no 1186 0.338287607663461 1669 690618 SGTC_1408 3909-7976 48.8 µM 0.415265348141929 0.35006619229624 no 1187 0.338973832603396 1627 24152374 SGTC_1414 3917-0015 5.4 µM 0.414157412284948 0.350452573704671 no 1188 0.339379414425846 1631 6618702 SGTC_1128 3448-9350 235 µM 0.413973516903056 0.350516720345517 no 1189 0.339446750989347 1589 619386 SGTC_611 3453-1652 23.7 µM 0.413733907003195 0.350600307797215 no 1190 0.339534496105203 1677 1560575 SGTC_1116 jasmonic acid  1.58368 µM 0.412869505112783 0.350901912824614 no 1191 0.339851112237971 1664 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_806 3966-4455 5.86 µM 0.409833046763842 0.351962130289437 no 1192 0.3409642112534 1548 714982 SGTC_2165 5727197 32.143 µM 0.409443465225473 0.352098241116959 no 1193 0.341107123802105 1675 1361712 SGTC_3005 9076496 71.4286 µM 0.408846664638508 0.35230678625975 no 1194 0.341326095972248 1660 21368410 SGTC_2185 6113692 200 µM 0.408635927530601 0.352380436547049 no 1195 0.341403430317206 1622 874150 SGTC_2776 terbinafine 19.92 µM 0.406206899774897 0.3532297538707 no 1196 0.342295292407515 1595 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_922 1866-0035 480 µM 0.404466275075999 0.353838819084884 no 1197 0.342934936449274 1652 3156169 SGTC_3138 9097216 49.47 µM 0.403762772857495 0.354085089140385 no 1198 0.343193587072343 1614 25237486 SGTC_1434 4073-0095 163 µM 0.403037746520553 0.354338957871009 no 1199 0.343460228168425 1630 24133745 SGTC_2826 7992541 19.48 µM 0.40259143502348 0.354495266508165 no 1200 0.343624405772698 1665 2985066 SGTC_3031 9088762 49.47 µM 0.400388147192511 0.355267267694385 no 1201 0.344435326468233 1558 205253 SGTC_568 1193-0097 7.48 µM 0.399574058638757 0.355552663465635 no 1202 0.344735133233316 1627 3646150 SGTC_7 0192-1582 4.227 µM 0.399481103967543 0.355585255825722 no 1203 0.344769372128722 1648 252616 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.399417169880682 0.355607673416227 no 1204 0.344792922328887 1632 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1142 3253-1408 9.78 µM 0.39796322576818 0.356117613214846 no 1205 0.345328646635858 1680 256655 SGTC_1618 st003135 44.5 µM 0.39739112568047 0.356318335719521 no 1206 0.345539529290968 1651 1270615 SGTC_1037 k284-1091 78.7 µM 0.392282694686919 0.358112398468864 no 1207 0.347424674339843 1612 3334711 SGTC_851 0394-0702 453 µM 0.392102087464021 0.358175884737033 no 1208 0.347491392598865 1742 762646 SGTC_1897 st060201 15 µM 0.389498734184555 0.359091439069342 no 1209 0.348453623422106 1597 611878 SGTC_457 grayanotoxin iii 135 µM 0.388408337676451 0.359475153628908 no 1210 0.348856937527484 1641 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_326 k292-0812 17.5 µM 0.386710688473406 0.360072844670338 no 1211 0.349485201193052 1753 3579357 SGTC_2222 6885208 172.143 µM 0.386611456964391 0.360107791690214 no 1212 0.34952193743067 1669 609514 SGTC_3242 9133940 49.47 µM 0.386356011686782 0.36019775892895 no 1213 0.34961651164235 1686 17248444 SGTC_757 1066-0008 322 µM 0.385017250837316 0.360669393943179 no 1214 0.350112317304796 1707 6842497 SGTC_542 3381-0244 89.3 µM 0.384216468814889 0.360951604592516 no 1215 0.350409006514172 1749 1112843 SGTC_2682 pyrogallin 40.03 µM 0.382470322072717 0.361567241933959 no 1216 0.351056269095549 1694 822798 An ATP competetive kinase inhibitor. SGTC_1062 mesoridazine 14.2 µM 0.381059937336599 0.362064761826272 no 1217 0.351579387010531 1664 4078 A neuroleptic. SGTC_1396 3511-0007 98.6 µM 0.380425681028911 0.362288574793343 no 1218 0.351814727193061 1642 X1396 SGTC_2086 5274770 176.623 µM 0.380065911150027 0.362415549393646 no 1219 0.351948244703182 1649 689278 SGTC_1670 st016595 4.04 µM 0.380026851036238 0.36242933590116 no 1220 0.351962741760417 1672 597879 SGTC_1990 st072050 59.8 µM 0.379666124442799 0.362556665001756 no 1221 0.352096634643128 1616 17233948 SGTC_870 0573-2213 57.6 µM 0.378391416585767 0.363006732470038 no 1222 0.352569921801285 1605 3916321 SGTC_309 k408-0051 1.48 µM 0.377523336153292 0.363313338337378 no 1223 0.352892362721143 1677 3640463 SGTC_350 k064-0020 19.8 µM 0.376945325836962 0.363517540081694 no 1224 0.353107118249005 1771 2790705 SGTC_2695 st077686 51.995 µM 0.375602165483441 0.363992206713825 no 1225 0.353606340318259 1617 2876092 SGTC_2911 7942208 15.64 µM 0.37514822591786 0.364152674082731 no 1226 0.353775116296725 1633 1243384 SGTC_2785 7756463 72.73 µM 0.374641033106494 0.364331994616686 no 1227 0.353963725976984 1602 2201551 SGTC_2951 9072950 58.06 µM 0.3743663926021 0.36442910752695 no 1228 0.35406587144296 1697 16488155 SGTC_1948 st076329 66.6 µM 0.374281648614146 0.364459074766959 no 1229 0.354097391908529 1617 24208413 SGTC_1352 1496-0991 99 µM 0.373052898476019 0.364893679425669 no 1230 0.354554536887346 1652 3000039 SGTC_1147 3809-1045 12.3 µM 0.372838099430196 0.364969670949008 no 1231 0.354634472399618 1634 325925 SGTC_2766 oltipraz 83.91 µM 0.372732487471572 0.3650070362521 no 1232 0.354673777277814 1749 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2047 4141938 200 µM 0.371038103182252 0.365606681116365 no 1233 0.355304575937285 1683 3807862 SGTC_2998 9066762 71.4286 µM 0.37092827722124 0.365645560025385 no 1234 0.355345476513154 1769 4945196 SGTC_1626 st003712 1.76 µM 0.370880449531021 0.365662491685099 no 1235 0.355363288670273 1714 24207035 SGTC_1702 st027038 51 µM 0.370643179850372 0.365746492282542 no 1236 0.355451658152858 1681 5521182 SGTC_2030 5175110 200 µM 0.370385388484366 0.365837765470135 no 1237 0.355547679606881 1733 2831986 SGTC_2965 9082772 38.63 µM 0.369682213243634 0.366086769138182 no 1238 0.355809643079996 1826 16459634 SGTC_580 1123-0028 41 µM 0.368608866979498 0.366466964007498 no 1239 0.356209642704181 1705 1677248 YPR107C YTH1 SGTC_3252 9135871 49.47 µM 0.368481004099946 0.366512263645562 no 1240 0.356257303406981 1719 17682838 SGTC_2293 7624732 200 µM 0.366296526725818 0.367286473548807 no 1241 0.357071910524978 1600 894453 SGTC_586 0957-0265 8.15 µM 0.366131131651645 0.36734511394333 no 1242 0.357133614119193 1738 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2654 protoveratrine a 100 µM 0.365570780115029 0.367543808117086 no 1243 0.357342691060667 1694 5702278 A heart drug and vasodilator. SGTC_2598 perillyl alcohol 100 µM 0.36552297072339 0.367560762417053 no 1244 0.357360531563379 1737 10819 An apoptosis inducer. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.364521468168514 0.367915977342168 no 1245 0.357734322828282 1596 641818 YHR062C RPP1 SGTC_951 1171-0579 82.7 µM 0.363831253443702 0.368160849864349 no 1246 0.357992011455097 1608 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2157 5649910 96.377 µM 0.36337608224426 0.368322363598272 no 1247 0.358161983036756 1628 2858091 SGTC_134 0269-0018 6.916 µM 0.361330497401547 0.369048509396006 no 1248 0.358926198963804 1632 4378915 SGTC_1647 st011722 22.4 µM 0.361313178095961 0.369054659437628 no 1249 0.358932671749299 1698 2854783 SGTC_420 mitomycin C 81.9 mM 0.361256413049422 0.369074816797107 no 1250 0.358953886969825 1670 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_609 0986-0026 86.3 µM 0.361155308744149 0.36911071999053 no 1251 0.35899167450681 1738 2848610 SGTC_893 0958-0369 48.9 µM 0.358095308374775 0.370197897005532 no 1252 0.360135994974124 1818 6819948 SGTC_1569 carminic acid 40.6 µM 0.357810222424962 0.370299237194879 no 1253 0.360242670001511 1813 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_750 4073-0104 132 µM 0.356625495670595 0.370720471244068 no 1254 0.360686094060662 1640 22330957 SGTC_3072 9116419 49.47 µM 0.356064208039393 0.370920093317503 no 1255 0.360896240394183 1649 17170162 SGTC_695 3505-6186 243 µM 0.355182494017568 0.371233745249949 no 1256 0.361226439300645 1734 1819379 SGTC_1179 1021-1431 9.29 µM 0.354370311727259 0.371522738372498 no 1257 0.361530690326975 1717 2840958 SGTC_2620 irigenin 100 µM 0.35358341580953 0.371802803111624 no 1258 0.361825552377587 1790 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2910 7948405 25.97 µM 0.35291513340294 0.372040705314849 no 1259 0.362076032552181 1827 2971328 SGTC_2323 6148992 148.28 µM 0.352762048889354 0.372095208831822 no 1260 0.362133418764761 1665 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_687 k029-0044 34.9 µM 0.352706121538365 0.372115121591819 no 1261 0.362154384812269 1831 5829338 SGTC_2558 carylophyllene oxide 100 µM 0.352289966797491 0.372263302934858 no 1262 0.362310405902087 1730 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3136 9095672 49.47 µM 0.352014004811188 0.372361575897026 no 1263 0.36241387976814 1832 17217380 SGTC_617 3770-0098 35 µM 0.351899968079788 0.372402188002412 no 1264 0.362456641569304 1715 5962639 SGTC_1467 k284-1082 293 µM 0.351840275310375 0.372423447061094 no 1265 0.36247902600927 1811 3334705 SGTC_3028 9087778 49.47 µM 0.350492310450431 0.372903616367259 no 1266 0.362984630002416 1633 17217395 SGTC_2658 polymyxin b sulfate 77.05 µM 0.349379366027953 0.373300216080267 no 1267 0.363402261012306 1696 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1182 1222-0449 220 µM 0.348335452295565 0.373672338629861 no 1268 0.363794135974208 1719 658318 SGTC_1662 st014054 52 µM 0.347428921450775 0.373995584068275 no 1269 0.364134554386222 1716 2838777 SGTC_1087 pterostilbene 9.05 µM 0.346561362039996 0.374305016302278 no 1270 0.364460438754378 1819 5281727 Similar to reservatol, lowers cholesterol. SGTC_2753 fluvastatin 17.09 µM 0.345867107769491 0.374552694174296 no 1271 0.364721294505882 1722 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2713 st079149 53.4 µM 0.342845593910476 0.37563123253134 no 1272 0.365857311712588 1728 3103253 SGTC_2930 9013230 14.89 µM 0.342802390871937 0.375646661056892 no 1273 0.365873563585385 1816 2995857 SGTC_2216 7189485 200 µM 0.342465056186836 0.375767135734773 no 1274 0.366000468499305 1789 731273 SGTC_415 dibenzyl ketone 100 µM 0.341197753119193 0.376219844613572 no 1275 0.36647735733067 1820 7593 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.340023031470505 0.376639633514843 no 1276 0.366919591793391 1714 521171 SGTC_738 1315-0003 72.4 µM 0.34001219467472 0.376643506743367 no 1277 0.366923672225282 1804 6251474 SGTC_2734 clemastine 41.6 µM 0.339092466527371 0.376972276181374 no 1278 0.367270036721338 1765 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1220 1838-0075 193 µM 0.338895773505455 0.377042598387879 no 1279 0.367344124249532 1757 5529645 SGTC_3215 9129942 49.47 µM 0.337715814218581 0.377464546082957 no 1280 0.367788678112684 1863 17682944 SGTC_2048 5246248 200 µM 0.334262645782223 0.378700221190232 no 1281 0.369090687614512 1846 677046 SGTC_3321 9137793 26.8275 µM 0.333570194592743 0.378948156372403 no 1282 0.369351956244653 1728 4904192 SGTC_422 cantharidin 155 µM 0.332638488036659 0.379281836579889 no 1283 0.369703593491209 1636 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1355 1499-0035 1.68 µM 0.330222648006318 0.380147460929496 no 1284 0.370615867582734 1697 1548538 SGTC_296 1222-0039 74.9 µM 0.330180696500685 0.38016249797366 no 1285 0.370631715834855 1688 5984176 SGTC_715 0868-0130 184 µM 0.329992911472502 0.380229809619402 no 1286 0.370702659112963 1883 2876258 SGTC_261 5-fluorouridine 15.376 µM 0.328353066116149 0.38081776702196 no 1287 0.371322362626741 1813 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_794 k038-0031 316 µM 0.327389951632571 0.381163214777548 no 1288 0.371686482762358 1712 6624242 SGTC_1984 st072354 53.1 µM 0.326206331456318 0.381587882732304 no 1289 0.372134125685878 1765 5762938 SGTC_2635 hydroquinidine 100 µM 0.323890155824506 0.382419309325922 no 1290 0.373010598560472 1730 442912 An experimental heart treatment. SGTC_1804 st050076 49.1 µM 0.322914399270569 0.38276973462234 no 1291 0.373380035491164 1785 3895976 SGTC_341 1486-1430 230 µM 0.322385666885996 0.382959659401343 no 1292 0.37358027062577 1692 2054753 YPL210C SRP72 SGTC_804 1595-0054 20.9 µM 0.321950975749756 0.383115824915146 no 1293 0.373744917165613 1733 761523 Stimulates phospholipase C. SGTC_1630 st005209 31.3 µM 0.321655427377166 0.383222013370548 no 1294 0.373856874217688 1885 3367314 SGTC_647 0140-0236 81 µM 0.321170075357229 0.383396415977679 no 1295 0.374040754116674 1777 990837 SGTC_2767 sibutramine 71.45 µM 0.3203856324924 0.383678341502058 no 1296 0.374338007812083 1876 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.320268471401055 0.383720454003916 no 1297 0.374382410792473 1887 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2617 dihydrotanshinone i 20.83 µM 0.320077438269377 0.383789122092254 no 1298 0.374454814172388 1704 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2705 st078069 42.8 µM 0.316323378214906 0.385139281072094 no 1299 0.37587853411572 1739 1530061 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.316113270607491 0.385214888237266 no 1300 0.375958267172628 1738 6857784 SGTC_16 erodoxin 22.806 µM 0.313577935179631 0.386127571221284 no 1301 0.37692081001299 1776 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2818 7996756 12.99 µM 0.313208553635022 0.386260595818074 no 1302 0.377061110141758 1728 2241621 SGTC_773 4358-1457 44.6 µM 0.312941689079312 0.38635670950813 no 1303 0.37716248191642 1923 1186886 SGTC_1469 k284-2957 126 µM 0.312676031398084 0.386452395457579 no 1304 0.377263403653891 1802 23884841 SGTC_997 3996-0078 137 µM 0.312602055114047 0.386479041845246 no 1305 0.37729150828685 1763 735687 SGTC_2703 st077852 53.4 µM 0.31064975452847 0.387182457069477 no 1306 0.378033449279118 1771 6281836 SGTC_3127 9126946 49.47 µM 0.310504394026246 0.387234845410011 no 1307 0.378088709277244 1694 27243249 SGTC_947 3447-0010 211 µM 0.308664513926029 0.387898120680096 no 1308 0.378788370155309 1767 748350 SGTC_1722 st034304 3.6505 µM 0.306989305585329 0.388502316568675 no 1309 0.379425756180345 1736 4036148 YLR033W RSC58 SGTC_1039 k821-0043 94 µM 0.305730439151828 0.388956528482726 no 1310 0.379904947609222 1870 15992768 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.305691073898502 0.388970734320724 no 1311 0.37991993509341 1741 16486 A toxic proline analog. SGTC_1285 0929-0069 65.5 µM 0.304912622006245 0.38925168668206 no 1312 0.380216351139526 1778 1206237 SGTC_919 tnp00227 403.569 nM 0.301394155679762 0.390522262532264 no 1313 0.381556975172434 1777 1269246 A methoxyflavone. YNL221C POP1 SGTC_3106 9121286 49.47 µM 0.301231782585027 0.390580926463407 no 1314 0.381618877851191 1867 15943471 SGTC_932 2857-0803 154 µM 0.300798796947936 0.390737372433208 no 1315 0.381783962920749 1884 674898 SGTC_2135 5326629 150.42 µM 0.300410038469821 0.39087785335776 no 1316 0.381932203757274 1743 5020077 SGTC_2883 9059145 45.46 µM 0.299000445591981 0.391387340107968 no 1317 0.382469852782576 1741 16476510 SGTC_814 3342-0569 96 µM 0.296884465181889 0.392152494998521 no 1318 0.383277358373149 1802 4346283 SGTC_2088 5278280 127.392 µM 0.29506923579405 0.392809228600197 no 1319 0.383970495127684 1801 791502 SGTC_733 4069-0007 56.1 µM 0.29440604149665 0.393049242546354 no 1320 0.384223825464812 1818 5717425 YNL287W SEC21 SGTC_3275 9138069 49.47 µM 0.290007663781768 0.394642066522506 no 1321 0.385905187296188 1839 17617007 SGTC_795 0685-0265 78 µM 0.289190237161527 0.394938283615151 no 1322 0.386217901223636 1775 302754 SGTC_2885 9057732 51.95 µM 0.289161445650803 0.394948718121872 no 1323 0.386228917024787 1798 6471414 SGTC_560 2332-1943 155 µM 0.287483954412446 0.395556797781598 no 1324 0.386870893086159 1797 21177716 SGTC_2459 5811157 9.22 µM 0.287422461843529 0.395579093279363 no 1325 0.386894432192322 1848 2870684 YBR192W RIM2 SGTC_879 0831-1030 162 µM 0.286926821438769 0.395758811197398 no 1326 0.387084176514539 1769 1549252 SGTC_1008 4106-0037 6 µM 0.285819027473086 0.39616057447857 no 1327 0.387508366991467 1817 2905394 SGTC_2931 9014674 55.67 µM 0.285812255137331 0.396163030939085 no 1328 0.387510960631272 1753 2996810 SGTC_3273 9137859 49.47 µM 0.284632400952801 0.396591050300405 no 1329 0.387962892602646 1895 2377234 SGTC_843 0310-0051 143 µM 0.284284760818606 0.3967171885855 no 1330 0.38809608184179 1824 2065037 SGTC_2552 juarezic acid 87.02 µM 0.284103244501734 0.396783054543193 no 1331 0.388165630310411 1845 1549512 SGTC_1144 3486-0183 12.5 µM 0.283686008800413 0.396934466028114 no 1332 0.388325508893859 1816 6744069 SGTC_418 lividomycin a 100 µM 0.280399068717485 0.398127811802472 no 1333 0.389585675729734 1915 72394 An antibiotic. SGTC_810 3825-7150 143 µM 0.279971283176186 0.398283192591996 no 1334 0.389749768442795 1977 22330411 YGL099W LSG1 SGTC_887 0885-0007 9.62 µM 0.279130810629024 0.398588517017018 no 1335 0.390072219490792 1893 5719458 SGTC_1270 0831-1170 17.3 µM 0.278792407476683 0.398711468672022 no 1336 0.390202070747453 1815 6764716 SGTC_2060 5238662 140 µM 0.278175750333616 0.398935543894211 no 1337 0.3904387244606 1787 790130 SGTC_57 miconazole 162.5 nM 0.278036372685201 0.398986194284973 no 1338 0.390492218868298 1745 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_840 0245-0196 390 µM 0.277525855078431 0.399171732929259 no 1339 0.390688177859629 1886 3827528 SGTC_1157 4092-0394 27.6 µM 0.276329506922248 0.399606613794693 no 1340 0.391147497308082 1901 3659885 SGTC_2065 5221596 34.26 µM 0.275390275976071 0.399948118092386 no 1341 0.391508207012164 1852 788581 SGTC_583 1488-1091 88.9 µM 0.272733069070273 0.400914692060843 no 1342 0.392529206288321 1975 4303273 SGTC_1867 st057372 64 µM 0.271493346926113 0.401365855956432 no 1343 0.393005808004109 1865 688837 SGTC_1604 st002052 72.4 µM 0.271398404088537 0.401400413306438 no 1344 0.393042314676005 1840 6254834 YHR062C RPP1 SGTC_976 1348-1067 47.6 µM 0.27038999900453 0.401767500728879 no 1345 0.39343011664893 1820 5310671 YGL099W LSG1 SGTC_2724 maprotiline 69.64 µM 0.266486963107078 0.403189128384907 no 1346 0.394932099227266 1904 4011 A tricyclic antidepressant. SGTC_3113 9123498 49.47 µM 0.265688460869892 0.403480130342927 no 1347 0.395239575485805 1968 8897275 SGTC_1376 2910-0861 41.3 µM 0.265454794324959 0.403565296666072 no 1348 0.395329564931858 1874 1112859 SGTC_1057 3448-5381 134 µM 0.264736161585487 0.40382725115753 no 1349 0.395606359077752 1928 5497911 SGTC_3175 9106517 49.47 µM 0.264568195722104 0.403888483944339 no 1350 0.395671061707276 1826 41468073 SGTC_2728 chlorpromazine 9.18 µM 0.263701465503698 0.404204492139107 no 1351 0.396004983093568 1875 2726 A thorazine and dopamine antagonist. SGTC_2945 9067681 61.76 µM 0.263390477284819 0.404317893105145 no 1352 0.396124814792995 1876 16456930 SGTC_2351 9026858 72.31 µM 0.262510736264105 0.404638731666391 no 1353 0.3964638545899 1768 1409300 SGTC_1477 0139-0234 16 µM 0.260953826089509 0.40520668856033 no 1354 0.397064057605938 1886 620880 SGTC_467 ro 31-8220 72.8 µM 0.259094304654961 0.405885298879015 no 1355 0.397781239513929 1956 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1559 coumarin 343 70.1 µM 0.258663257965339 0.406042644726025 no 1356 0.397947535418758 1918 108770 A hepatotoxic, DNA x-linker. SGTC_1507 4075-3230 155 µM 0.257118110422696 0.406606797612042 no 1357 0.398543798662131 1976 659771 SGTC_506 n9-isopropylolomoucine 153 µM 0.255784771385198 0.407093772434208 no 1358 0.399058516754006 2022 6610355 SGTC_2189 6047310 154.431 µM 0.255357798418377 0.407249745983699 no 1359 0.399223381236882 1850 711535 SGTC_2319 6033012 152.6 µM 0.254432394196946 0.407587847302495 no 1360 0.399580763622444 1788 847246 SGTC_1741 st038134 10.228 µM 0.251424535474009 0.408687258682266 no 1361 0.400742950125892 1948 1272587 SGTC_2349 9023730 187.07 µM 0.251317674447713 0.408726331049079 no 1362 0.400784255677844 1951 4126287 SGTC_1018 4259-0013 28.1 µM 0.250597801734761 0.408989566915618 no 1363 0.401062540731779 1871 6801262 SGTC_2507 purpurin 79.67 µM 0.250455786301151 0.409041502553502 no 1364 0.401117446332926 1759 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3270 9137563 49.47 µM 0.250351146168678 0.409079770909316 no 1365 0.401157903251625 1938 17015724 SGTC_1556 plumbagin 1.48 µM 0.249821133507524 0.409273617235217 no 1366 0.40136283783288 1953 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1921 5740136 50 µM 0.249739905027289 0.409303327624102 no 1367 0.401394248019034 2001 1774243 SGTC_693 4161-2696 114 µM 0.24866472098279 0.409696639404037 no 1368 0.401810070173401 1948 805759 SGTC_1383 3049-0032 20.7 µM 0.248393162717771 0.409795992198586 no 1369 0.401915111605832 1977 712864 SGTC_1235 benzylparaben 21.5 µM 0.248028398109197 0.409929454747608 no 1370 0.402056217326777 1880 7180 SGTC_2347 9049783 174.81 µM 0.24777745267256 0.410021278426147 no 1371 0.402153300596958 1938 6467988 YPL169C MEX67 SGTC_1405 3909-7894 12 µM 0.246976712160709 0.410314311101495 no 1372 0.402463123443264 1970 7104060 SGTC_838 0109-0203 71.4 µM 0.246130448523561 0.410624057490802 no 1373 0.402790626714546 1871 759422 SGTC_3331 9141060 1.957 µM 0.245398965521505 0.410891837211415 no 1374 0.403073764961449 1813 4906567 YPR165W RHO1 SGTC_2297 7971671 152.32 µM 0.244446966240744 0.411240405239891 no 1375 0.403442335487803 1950 909016 SGTC_2273 7815444 169.05 µM 0.244104095145445 0.411365962327495 no 1376 0.403575100502105 2006 2824616 SGTC_1884 5633444 25 µM 0.24332728091988 0.411650460033829 no 1377 0.403875936122729 1892 5724239 SGTC_3112 9123419 49.47 µM 0.241295281320923 0.412394871737616 no 1378 0.404663133912252 1946 17015854 SGTC_1209 2323-2347 50.3 µM 0.240040210492378 0.412854817597365 no 1379 0.405149542122468 2029 5412760 SGTC_754 3474-0146 171 µM 0.239751807859064 0.412960525453474 no 1380 0.405261334564075 1766 24762078 SGTC_185 k048-0037 25.491 µM 0.235870089710111 0.41438389789908 no 1381 0.406766739207779 2007 6827589 SGTC_3352 9151559 45.5865 µM 0.235475863378459 0.41452851849811 no 1382 0.406919705223145 1878 17159339 SGTC_50 0929-0078 56.389 µM 0.234561527598642 0.41486398406315 no 1383 0.407274536506461 1956 1377751 SGTC_1194 1488-0194 225 µM 0.233423841088717 0.415281482648827 no 1384 0.407716150962405 1894 1391452 SGTC_2223 6903751 107.57 µM 0.232892651581011 0.415476446880554 no 1385 0.407922382378561 1954 5598863 SGTC_1836 st055642 81 µM 0.232760095967762 0.415525102449643 no 1386 0.407973850349256 1811 8571 SGTC_336 4111-0029 111 µM 0.232447121980834 0.415639987124492 no 1387 0.408095376481726 1856 3131175 SGTC_818 4072-2707 53.5 µM 0.22952724155636 0.416712146072782 no 1388 0.409229575006997 1882 882871 SGTC_2178 5812956 200 µM 0.229489283160754 0.416726088219341 no 1389 0.409244324595038 1958 5403383 SGTC_1686 st019653 115.5 µM 0.227553566800684 0.417437216755065 no 1390 0.409996660605713 2005 97252 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.227238975477922 0.417552814466167 no 1391 0.410118961131184 2043 551469 SGTC_1336 1486-0901 104 µM 0.224304604503652 0.41863140152435 no 1392 0.41126014680564 1928 5006114 SGTC_148 3253-0744 288.01 µM 0.224015444777133 0.418737721253777 no 1393 0.411372642711375 1993 6893655 SGTC_108 0509-0257 621.132 µM 0.223821429046945 0.418809061279332 no 1394 0.411448127485699 2000 536624 SGTC_3167 9103034 49.47 µM 0.223625979780281 0.418880931119239 no 1395 0.41152417331362 1945 5127859 SGTC_504 lovastatin 124 µM 0.223304762448994 0.418999053779925 no 1396 0.411649160474018 1847 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2133 5320837 200 µM 0.221770259273217 0.419563443960746 no 1397 0.412246366314453 1982 2841355 SGTC_799 1310-0557 151 µM 0.22023468707386 0.420128393018621 no 1398 0.412844191683108 1930 5354492 SGTC_1862 st057513 3.81 µM 0.220140675751274 0.420162985880782 no 1399 0.412880798533313 1907 5393163 SGTC_2532 xanthone 78.9 µM 0.220085880691903 0.420183148821069 no 1400 0.412902135403511 1984 7020 An insecticide. SGTC_903 1134-0042 114 µM 0.219815240826487 0.420282739255008 no 1401 0.413007524730235 1895 701009 SGTC_685 1278-0033 54.9 µM 0.219562016280019 0.420375925797577 no 1402 0.413106138070379 1994 3590572 SGTC_2266 7929956 200 µM 0.219283579410277 0.420478395617634 no 1403 0.413214576184742 1915 2967153 SGTC_719 2810-4230 27.3 µM 0.219046221337635 0.420565751950566 no 1404 0.413307021260609 1942 721079 SGTC_780 0109-0199 192 µM 0.218062711857847 0.420927760560279 no 1405 0.413690124948304 2035 610414 SGTC_3328 9140624 29.0385 µM 0.217719455309429 0.421054121643744 no 1406 0.413823852070498 2018 4904392 SGTC_490 phenamil 164 µM 0.215400752888251 0.421907904780585 no 1407 0.414727441531262 2023 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_197 4544-0043 41.561 µM 0.214128491941089 0.422376527776297 no 1408 0.415223428845836 2022 896523 SGTC_288 1315-0019 35.1 µM 0.211993210213111 0.423163281450735 no 1409 0.416056165704391 1943 6811474 SGTC_1615 st002656 86.5 µM 0.211742492061962 0.423255679792125 no 1410 0.416153967885207 1960 1584458 SGTC_2714 st079313 56.9 µM 0.211426728458973 0.423372055645391 no 1411 0.4162771509131 1907 2939799 SGTC_2855 9016525 58.44 µM 0.210728692446318 0.42362934313122 no 1412 0.416549491990825 1967 43811474 SGTC_2512 diallyl trisulfide 49.23 µM 0.210267588362211 0.423799318290042 no 1413 0.416729415267847 2042 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2691 st077356 60.2 µM 0.209753175880902 0.423988961064481 no 1414 0.416930160120598 1987 2839272 SGTC_2140 5586273 200 µM 0.209719838560694 0.424001251774385 no 1415 0.416943170458465 2006 854421 SGTC_1841 st054148 70 µM 0.208901883608058 0.424302836245622 no 1416 0.417262416848375 1903 675442 SGTC_2681 menadione 3.18 µM 0.207681129582153 0.424753017336909 no 1417 0.417738976419017 1951 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.207291820524669 0.424896604667413 no 1418 0.417890980848614 1941 2333 A French combination drug. SGTC_764 1951-2361 146 µM 0.20678863955501 0.425082205688788 no 1419 0.418087464359613 1846 5438930 SGTC_1245 0418-0076 17.2 µM 0.206280824737965 0.425269532766788 no 1420 0.418285778037022 1947 6790114 SGTC_1822 st052468 42 µM 0.20443669444654 0.425949952930805 no 1421 0.419006128811087 1941 2873678 SGTC_3032 9089427 49.47 µM 0.204101041401275 0.42607382105295 no 1422 0.419137270272695 1933 17173707 SGTC_902 1120-0002 2.07 µM 0.203810803498757 0.426180935224648 no 1423 0.419250675035955 1932 3280475 SGTC_921 1561-0023 372 µM 0.201898021748947 0.426886995535761 no 1424 0.419998224323251 1884 24050882 SGTC_2592 piperlongumine 83.33 µM 0.2007260670111 0.427319712149325 no 1425 0.420456387999542 1896 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1475 4092-1048 11.7 µM 0.199124872736049 0.42791105659975 no 1426 0.421082532589741 1967 2881759 SGTC_1407 3909-7909 12.3 µM 0.198844690039215 0.428014548851328 no 1427 0.421192118177917 1956 4411780 SGTC_213 1246-0773 967 nM 0.198546787842475 0.428124591660087 no 1428 0.421308640947234 1992 6251622 SGTC_3166 9102297 49.47 µM 0.198527972662916 0.428131542032267 no 1429 0.421316000630435 1906 25237072 SGTC_1696 st025591 34.7925 µM 0.197956150987152 0.428342784948187 no 1430 0.421539685601608 1957 2787147 SGTC_300 r073-0011 5.04 µM 0.196218593447845 0.428984800885218 no 1431 0.422219537734422 2099 2735780 SGTC_2336 9001819 198.65 µM 0.194166513201809 0.429743272786043 no 1432 0.423022751223819 2024 2989602 SGTC_2283 7944793 200 µM 0.193584307265291 0.429958509994028 no 1433 0.423250693368149 1908 2970533 SGTC_897 1000-0139 31.4 µM 0.192785149392806 0.430253986606389 no 1434 0.423563617191608 2077 6151020 SGTC_1648 st011736 69.8 µM 0.192439343380871 0.430381855299371 no 1435 0.42369903835919 2038 2855514 SGTC_209 4077-0173 175.592 µM 0.192233804531426 0.43045786086216 no 1436 0.423779533743959 2000 15993494 SGTC_2710 st078562 53.7235 µM 0.191695894909334 0.430656784951872 no 1437 0.423990210871605 2026 17250908 SGTC_2846 9008642 19.48 µM 0.19060282124517 0.431061068137375 no 1438 0.424418389841653 1924 2992898 SGTC_1297 1068-0111 14.1 µM 0.18984073451908 0.43134297557802 no 1439 0.424716967375521 1926 767057 SGTC_637 1181-0519 7.26 µM 0.188095280294666 0.431988777142791 no 1440 0.425400980422357 2018 6252091 YGR060W ERG25 SGTC_2276 7947513 42.08 µM 0.187921049958401 0.43205325072709 no 1441 0.425469270612406 1808 2105100 SGTC_290 2043-6722 48.1 µM 0.187518177891331 0.432202339649769 no 1442 0.425627186288295 2029 773758 YLR208W SEC13 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.185713078811347 0.432870462208052 no 1443 0.426334885669427 1996 229346 A bile salt which induces apoptosis. SGTC_1389 3405-0187 19 µM 0.181978354977787 0.434253405408438 no 1444 0.427799856244747 1918 799890 SGTC_3254 9136651 49.47 µM 0.181815860614152 0.434313594378878 no 1445 0.427863618506239 1999 16454030 SGTC_2377 9073351 62.6 µM 0.181805242076222 0.434317527607493 no 1446 0.427867785251689 1901 7337946 YHR072W ERG7 SGTC_2332 7982454 138.89 µM 0.180765147669356 0.434702821991695 no 1447 0.428275960260708 2072 2981748 SGTC_414 piperonyl butoxide 100 µM 0.179620578017197 0.43512689003486 no 1448 0.428725224255111 1951 5794 A potent inhibitor of cytochrome P450. SGTC_2853 9015042 58.44 µM 0.17822416913588 0.435644366629772 no 1449 0.429273464676352 1999 6457456 SGTC_2908 7930301 100 µM 0.176860378171825 0.436149862173711 no 1450 0.42980903078624 2046 2223178 SGTC_2782 7736369 71.43 µM 0.176835915078789 0.436158930489138 no 1451 0.429818638722093 1967 2950836 YOL077C BRX1 SGTC_107 0358-0022 2.6945 µM 0.175693754029607 0.436582359720434 no 1452 0.430267271269279 2088 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1774 st048371 48.465 µM 0.175388384686622 0.436695580524476 no 1453 0.430387233402214 1919 4242727 SGTC_1821 st053465 65.6 µM 0.175377671040015 0.43669955288281 no 1454 0.430391442297354 1986 675086 SGTC_834 0312-0008 75.7 µM 0.175353030260304 0.436708689105961 no 1455 0.430401122547534 2013 6385573 YIL048W NEO1 SGTC_1993 st073995 70.8 µM 0.174188174751426 0.437140628643174 no 1456 0.430858789326205 2014 3098394 SGTC_2226 7298446 200 µM 0.170033429883766 0.438681854484398 no 1457 0.432491923096363 2110 3283010 SGTC_1244 0416-0015 52.5 µM 0.169595251553005 0.438844453821181 no 1458 0.432664228581743 1992 96201 SGTC_520 3584-0023 682 µM 0.168505234175001 0.439248982487724 no 1459 0.433092913136394 1943 1340790 SGTC_3006 9075424 71.4286 µM 0.168469082265054 0.439262400321026 no 1460 0.433107132395015 1970 7465181 SGTC_1731 st035964 63 µM 0.168162962849485 0.439376019777546 no 1461 0.433227538663345 1927 6739575 SGTC_655 k060-0012 42 µM 0.167313885442593 0.439691189940854 no 1462 0.43356153956899 1997 5994525 SGTC_3130 9127414 49.47 µM 0.167046494066011 0.439790451222902 no 1463 0.433666732938515 2165 1494646 SGTC_3339 9145883 14.936 µM 0.16677312625268 0.439891934996288 no 1464 0.433774282331468 2093 2030670 SGTC_3087 9117406 49.47 µM 0.163854440439975 0.440975698978057 no 1465 0.434922866755923 2003 42546093 SGTC_782 0083-0095 30.5 µM 0.163338074355791 0.441167481869343 no 1466 0.435126128711285 2162 3591729 An indicator and reagent. SGTC_2957 9076800 11.52 µM 0.162508989586974 0.44147544006429 no 1467 0.435452524853717 1977 16459615 SGTC_616 4092-0450 108 µM 0.162115048515764 0.441621779349192 no 1468 0.435607627975478 2048 787165 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.161639815221639 0.441798327271764 no 1469 0.435794750784707 2026 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2398 5228213 48.84 µM 0.159996350728566 0.442408958940078 no 1470 0.436441974441547 2140 80771 YMR134W ERG29 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.159780129226227 0.442489306577729 no 1471 0.436527138772577 1995 5282362 SGTC_3201 9113999 49.47 µM 0.159488866468631 0.442597543190214 no 1472 0.436641864658653 2062 16649224 SGTC_2715 st079500 56.4 µM 0.158990855548132 0.442782619735106 no 1473 0.436838039203045 2006 28246688 SGTC_638 3970-0837 4.09 µM 0.157903752609085 0.443186664752186 no 1474 0.437266320505098 1983 4118451 YLR208W SEC13 SGTC_2115 tiliquinol 12.7705 µM 0.157805506055846 0.443223183098554 no 1475 0.437305029910069 2065 71208 A bioactive hydroxyquinoline. SGTC_2233 sulbentine 40.3845 µM 0.155671328118407 0.444016577764509 no 1476 0.438146049225128 2081 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2009 4012297 12.05 µM 0.155507213184055 0.444077597901952 no 1477 0.438210733909552 1983 45595307 SGTC_2529 gangaleoidin 93.61 µM 0.15480253690315 0.444339621059509 no 1478 0.438488495581352 2036 4565183 SGTC_2810 7959871 45.46 µM 0.153212690025804 0.444930870629297 no 1479 0.439115275315989 2083 2974535 SGTC_2286 7945697 125 µM 0.150700964786947 0.445865207570772 no 1480 0.44010580606885 1985 1245733 SGTC_98 0074-0023 107.663 µM 0.149959764878158 0.446140984299367 no 1481 0.440398179601592 1986 3563821 SGTC_596 1155-0152 116 µM 0.149120409266221 0.446453313071822 no 1482 0.440729310840205 2043 280313 SGTC_2394 5221648 200 µM 0.148113812959316 0.446827916807463 no 1483 0.441126474258156 2080 788586 SGTC_2583 asiatic acid 100 µM 0.147754705918025 0.446961569608251 no 1484 0.441268178162255 2075 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2830 7992007 71.43 µM 0.147590195799726 0.447022799153699 no 1485 0.441333096488925 1960 1952075 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.146884255591786 0.447285559608625 no 1486 0.441611689670949 2007 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1992 st073643 23.3 µM 0.145649811020033 0.447745092047678 no 1487 0.442098921863351 2135 3161292 SGTC_985 1493-0307 8.71 µM 0.14523940993041 0.447897882893374 no 1488 0.442260925590401 2161 3278274 SGTC_2756 carbadox 75.1 µM 0.145223067693252 0.447903967209531 no 1489 0.442267376804873 2020 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1819 st053448 58.6 µM 0.144909055248678 0.448020878367111 no 1490 0.442391338424581 2069 2857616 SGTC_1293 1000-1278 195 µM 0.144107163443331 0.448319454193946 no 1491 0.442707924079442 2119 678847 SGTC_1155 4088-0394 48.2 µM 0.140519797492567 0.449655527586224 no 1492 0.444124655770555 1992 2326248 SGTC_1101 ebselen 5.29 µM 0.139165067144561 0.450160230732641 no 1493 0.444659856112236 2175 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.137969770984262 0.450605603838081 no 1494 0.445132154144278 2032 75037 A free radical scavenger. SGTC_1764 st044502 93.5 µM 0.137681892448677 0.450712878082696 no 1495 0.445245915413522 2058 8407 SGTC_79 0052-0007 94.094 µM 0.137358683413393 0.450833322074978 no 1496 0.445373643646854 2139 2801472 SGTC_496 calpeptin 138 µM 0.137001231788108 0.450966531855751 no 1497 0.445514910733523 2048 73364 A calpain inhibitor. SGTC_909 3448-9333 149 µM 0.136664105238342 0.451092172249145 no 1498 0.445648151564636 2051 3344074 SGTC_1697 st025554 27.742 µM 0.135050809553638 0.451693483237876 no 1499 0.446285851027378 2138 1269519 SGTC_1756 st041558 35.5 µM 0.133607601251392 0.452231492871889 no 1500 0.446856436578281 2210 3955792 SGTC_253 dyclonine 31.25 µM 0.132972743656439 0.452468187521555 no 1501 0.447107468228855 2118 3180 An oral anasthetic. SGTC_3173 9105693 49.47 µM 0.132960839637653 0.45247262587147 no 1502 0.447112175448568 2126 17096658 SGTC_1616 st002734 56.1 µM 0.131691592661783 0.452945891800104 no 1503 0.447614117841665 2082 4026101 SGTC_1425 4048-4433 7.33 µM 0.130803988109291 0.453276893934437 no 1504 0.447965184025396 2169 23734946 SGTC_195 4234-0266 16.654 µM 0.130748816751552 0.453297469302616 no 1505 0.44798700680085 2058 2303354 SGTC_2636 apigenin dimethyl ether 100 µM 0.130380167557531 0.453434954957907 no 1506 0.448132828322005 2092 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1007 4101-0031 70 µM 0.129027577819689 0.453939443418266 no 1507 0.448667913637651 2183 1146276 SGTC_174 3553-0389 74.3 µM 0.127852423001224 0.454377812633094 no 1508 0.449132881444982 2118 738071 SGTC_3162 9099653 49.47 µM 0.127652003560995 0.454452580865844 no 1509 0.449212187423963 2176 25237511 SGTC_724 3910-0327 137 µM 0.127147570055644 0.454640771353125 no 1510 0.449411800751238 2068 2885483 SGTC_1098 clofazimine 15.1 µM 0.127147132948149 0.454640934430521 no 1511 0.449411973728023 2155 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2926 9010726 65.15 µM 0.127088845042586 0.454662680728446 no 1512 0.44943504011838 2043 2994293 SGTC_3346 9158254 43.5805 µM 0.126762293303179 0.454784514541493 no 1513 0.449564270254432 2092 17639500 SGTC_1552 6-methylflavone 10.6 µM 0.126558682862513 0.454860482103882 no 1514 0.449644850102084 2191 689013 SGTC_445 e6 berbamine 66 µM 0.123090634776119 0.456154670755993 no 1515 0.451017663624988 2100 6610268 A calcium/calmodulin antagonist. SGTC_102 gallobenzophenone 83.616 µM 0.12275062598493 0.456281578785472 no 1516 0.451152286613652 2185 70837 SGTC_3249 9135183 49.47 µM 0.119683746393465 0.457426489314821 no 1517 0.452366838149685 2131 4902779 SGTC_1374 2889-5571 141 µM 0.119644361888025 0.457441194439294 no 1518 0.452382438200939 2084 2853281 SGTC_963 1269-2853 151 µM 0.119623799796062 0.457448871799468 no 1519 0.452390582795757 2077 3668223 SGTC_735 3076-0345 636 µM 0.118988187858966 0.457686200887105 no 1520 0.452642357008686 2188 2888990 SGTC_2461 5755302 26.15 µM 0.117126555971981 0.458381396108228 no 1521 0.453379882973056 2201 2788904 SGTC_1189 1431-2119 7.28 µM 0.116969883520283 0.458439908647147 no 1522 0.453441959544977 2196 3107275 SGTC_1199 1638-0010 4.46 µM 0.116882441635227 0.458472566003358 no 1523 0.45347660615911 2061 3111136 SGTC_1185 1319-0113 81.3 µM 0.11443340634223 0.459387332472145 no 1524 0.454447116745349 2123 4672763 SGTC_567 1080-0542 68.4 µM 0.113519956500379 0.459728580629235 no 1525 0.454809171174458 2206 5950415 SGTC_1628 st004252 77.7 µM 0.113187938683025 0.459852623779543 no 1526 0.454940778875764 2180 692968 SGTC_1278 0874-0585 172 µM 0.111879915242357 0.460341344343279 no 1527 0.455459310961142 2130 766306 SGTC_713 1488-1073 324 µM 0.110409070793202 0.460890971723644 no 1528 0.456042479829563 2223 3312542 SGTC_600 1495-0418 41.6 µM 0.109973550905198 0.461053731839856 no 1529 0.456215175490297 2137 5377768 SGTC_377 3970-0964 33.1 µM 0.109890441563995 0.4610847917515 no 1530 0.456248131579638 2151 16481235 SGTC_1341 1486-1360 280 µM 0.109156630553847 0.461359044431006 no 1531 0.456539129249051 2126 3976547 SGTC_159 3970-0959 50 µM 0.108616565592411 0.461560898697043 no 1532 0.456753310525026 2175 6615653 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.108402688596172 0.461640839939424 no 1533 0.456838134256944 2219 1273210 SGTC_3341 9147222 25.867 µM 0.10839515402138 0.461643656181136 no 1534 0.456841122509249 2130 1939759 SGTC_535 2293-4129 48.2 µM 0.106195403980148 0.462465951176033 no 1535 0.457713658710235 2211 396118 YIL048W NEO1 SGTC_353 1988-1175 58.3 µM 0.104187828160768 0.463216549080645 no 1536 0.45851014656091 2117 2788357 SGTC_1780 st038448 24.544 µM 0.104123961356332 0.463240429938813 no 1537 0.458535487898911 2170 728868 YDL195W SEC31 SGTC_2348 9022543 33.42 µM 0.103801069015999 0.463361166769944 no 1538 0.458663609050904 2148 3162678 YDL140C RPO21 SGTC_1607 st000305 50.6 µM 0.103565096884981 0.46344940428187 no 1539 0.458757243661157 2206 5457690 SGTC_3098 9119039 49.47 µM 0.102115994589026 0.463991309149848 no 1540 0.459332302767269 2250 17161528 SGTC_2557 derrustone 83.84 µM 0.101050616496881 0.464389759564947 no 1541 0.459755139811774 2051 629853 An antioxidant. SGTC_3083 9117465 49.47 µM 0.100647949970281 0.46454036579308 no 1542 0.459914965682258 2067 16420915 SGTC_2854 9024559 71.43 µM 0.100469504519008 0.46460710998278 no 1543 0.459985796089979 2140 3163529 SGTC_2650 prasterone 100 µM 0.100111031576569 0.464741193102568 no 1544 0.460128088700573 2224 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_368 fentichlor 4.58 µM 0.0999849265584542 0.464788362341266 no 1545 0.460178146168501 2118 7329 A pesticide. SGTC_1540 guanosine 70.6 µM 0.0998615073764355 0.464834527429416 no 1546 0.460227138103209 2204 6802 Guanosine is a purine nucleoside SGTC_346 4513-0042 7.16 µM 0.0996923620338708 0.464897797209717 no 1547 0.460294282273821 2199 2827372 SGTC_2174 5790901 200 µM 0.0989354640794706 0.465180930056045 no 1548 0.460594755381546 2150 786020 SGTC_1562 morin hydrate 59.1 µM 0.0985088389628627 0.465340525507077 no 1549 0.460764126810583 2144 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_990 3985-0011 41.3 µM 0.098387183540413 0.465386036396041 no 1550 0.460812425677599 2183 5399565 YGL099W LSG1 SGTC_1124 fisetin 1.16336 µM 0.0979924480312312 0.465533708752014 no 1551 0.460969145052347 2077 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1029 k015-0030 64.7 µM 0.09700109318057 0.465904600010447 no 1552 0.461362763156189 2148 2208316 SGTC_1494 4358-1428 177 µM 0.0958945024037906 0.466318638947423 no 1553 0.461802180452693 2258 1564571 SGTC_2111 5486399 200 µM 0.0944489713240296 0.466859549693866 no 1554 0.462376258072338 2223 689674 SGTC_1097 itavastatin 7.23 µM 0.092456674238413 0.467605157754251 no 1555 0.463167606336453 2243 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_407 eburnamonine 100 µM 0.092246471870443 0.46768383170248 no 1556 0.46325110810252 2158 3195 SGTC_1261 0712-0010 12.7 µM 0.0913243618451234 0.468028971310717 no 1557 0.463617430458587 2217 2840123 SGTC_626 0214-0009 33 µM 0.0909653945337846 0.468163336885126 no 1558 0.463760044090181 2199 3437874 SGTC_2880 9042983 58.44 µM 0.0903229316758324 0.468403827132972 no 1559 0.464015298893267 2164 6464714 SGTC_2067 5224629 34.075 µM 0.089941752635521 0.468546517633752 no 1560 0.464166750890995 2139 2835000 SGTC_2387 9077560 195.08 µM 0.0890403070650125 0.468883980667923 no 1561 0.464524938456515 2160 5303272 SGTC_37 0566-0070 1.56 µM 0.0885663478069207 0.469061419918918 no 1562 0.464713276755163 2227 1626686 SGTC_1271 0832-2808 169 µM 0.0881231751161213 0.469227338959963 no 1563 0.464889388476776 2237 3663794 SGTC_1059 3448-6867 171 µM 0.0854771758451686 0.470218082559892 no 1564 0.465941020044527 2279 3934407 SGTC_1709 st033179 39.1045 µM 0.0819788594240222 0.471528241995126 no 1565 0.467331762298405 2267 573381 SGTC_344 k064-0035 6.43 µM 0.0818277113186203 0.471584855733185 no 1566 0.467391859758441 2144 5088750 SGTC_3081 9117243 49.47 µM 0.0812003368708031 0.471819850001481 no 1567 0.467641315809164 2237 45595589 SGTC_60 0986-0278 202 µM 0.0811892901064858 0.47182398785185 no 1568 0.467645708327569 2038 3110598 SGTC_3333 9141820 12.094 µM 0.0801989306403582 0.472194964826981 no 1569 0.468039520324706 2142 1939433 SGTC_483 fpl-64176 144 µM 0.0796055588114617 0.47241724649256 no 1570 0.468275486979203 2252 3423 SGTC_972 1319-0219 195 µM 0.0794632904824462 0.472470542585739 no 1571 0.468332064600243 2168 23903702 SGTC_751 0833-0568 350 µM 0.078764552479605 0.472732308653833 no 1572 0.468609949721433 2199 6954252 SGTC_3034 9090421 49.47 µM 0.0762950817486321 0.473657532472706 no 1573 0.469592169318537 2271 17173761 SGTC_3054 9094397 49.47 µM 0.076143749181225 0.473714236134789 no 1574 0.469652367167151 2245 2598354 SGTC_2676 harmalol 100 µM 0.0759594240124062 0.473783302702002 no 1575 0.469725689919654 2265 5459187 A monoamine oxidase inhibitor SGTC_1506 4226-2149 212 µM 0.0745213109445071 0.474322189992624 no 1576 0.470297792315131 2168 991114 SGTC_2801 7907800 81.82 µM 0.073059650543695 0.474869949041187 no 1577 0.470879325006887 2197 6620925 SGTC_1063 disulfiram 1.84 µM 0.0721475960174001 0.475211766741499 no 1578 0.471242224372151 2286 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2862 9027634 71.43 µM 0.0718973390564886 0.475305560671088 no 1579 0.471341803848233 2249 5012562 SGTC_3189 9110682 49.47 µM 0.071564261256468 0.475430397185644 no 1580 0.471474341252871 2203 17122418 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0713845779685163 0.475497742920612 no 1581 0.471545841646778 2276 1377 SGTC_920 mycophenolic acid 780.421 nM 0.071050563446022 0.475622934237662 no 1582 0.471678756665036 2213 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_553 k007-0256 45.7 µM 0.0689201930369833 0.476421470226361 no 1583 0.47252657250858 2213 6287000 SGTC_962 1254-0300 21.5 µM 0.0680670429619411 0.47674128690806 no 1584 0.472866132697654 2246 7340576 SGTC_2903 5923464 63.88 µM 0.0679749085009518 0.476775825855293 no 1585 0.47290280409482 2292 2876576 SGTC_262 fenpropimorph 62.5 µM 0.0677354029554334 0.476865611419308 no 1586 0.472998133267166 2269 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_155 k072-0202 43.6 µM 0.0663938668259913 0.477368546527624 no 1587 0.473532126497255 2298 5857737 SGTC_2105 5350118 200 µM 0.0659104600612371 0.477549782155046 no 1588 0.47372455638445 2225 2133313 SGTC_1153 4055-0057 267 µM 0.0658304540023779 0.477579777939756 no 1589 0.473756405014723 2202 882706 SGTC_3097 9117246 49.47 µM 0.0648243823995017 0.477956983997832 no 1590 0.474156913964579 2287 16423892 SGTC_1856 st057054 55.7 µM 0.0641573420766624 0.478207088089897 no 1591 0.474422471735729 2285 1266018 SGTC_1567 st069303 68.4 µM 0.0639449709435482 0.478286717599885 no 1592 0.474507021945942 2204 5581319 SGTC_1308 1187-1617 41.4 µM 0.0638226419986244 0.478332585780733 no 1593 0.474555724651395 2273 2882570 SGTC_2468 5987765 72.9 µM 0.0622634878904334 0.478917227563803 no 1594 0.475176502239591 2218 26772094 SGTC_1840 st055363 71 µM 0.0622119576316018 0.478936550836924 no 1595 0.475197020061808 2154 676033 SGTC_3264 9137442 49.47 µM 0.0621197223783178 0.478971138153181 no 1596 0.475233745570919 2290 17015726 SGTC_2897 9048598 12.99 µM 0.0615302709648103 0.479192180386523 no 1597 0.475468453663786 2267 6467404 SGTC_2493 resveratrol 26.09 µM 0.0594208566414126 0.479983255384896 no 1598 0.476308450605701 2297 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1441 4106-0040 13 µM 0.0583256341490573 0.480394018283184 no 1599 0.476744624584829 2299 2904180 SGTC_95 0471-0001 561.058 µM 0.0577656424949415 0.480604051072405 no 1600 0.476967652888559 2197 4015405 SGTC_2122 5258151 111.688 µM 0.0574732843686141 0.480713706265313 no 1601 0.477084093453748 2255 2173356 SGTC_1070 indatraline 8.81 µM 0.0569507021822868 0.480909715565684 no 1602 0.477292232659702 2219 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_446 go6976 132 µM 0.0510373954586641 0.483127979567167 no 1603 0.479647861048592 2301 3501 A protein kinase C inhibitor. SGTC_384 k007-0144 5.16 µM 0.0497451703501682 0.483612805050817 no 1604 0.480162730130493 2246 6824886 SGTC_2587 piperic acid 92.2 µM 0.0497177192713016 0.483623104591834 no 1605 0.480173667992278 2269 5370536 SGTC_1805 st050013 60.3 µM 0.0493170687733252 0.483773428384194 no 1606 0.480333308577349 2289 4037144 SGTC_2688 kanamycin b 96.69 µM 0.0492541578988799 0.483797032711249 no 1607 0.480358375921374 2260 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_581 0958-0271 211 µM 0.0487493906547254 0.483986424769528 no 1608 0.480559507293983 2321 4591145 SGTC_2434 5670830 169.91 µM 0.0483222864341109 0.484146679963685 no 1609 0.480729696646449 2261 1549830 SGTC_1337 1486-1011 40.3 µM 0.0471614720214292 0.484582245861223 no 1610 0.481192267103499 2335 X1337 SGTC_1333 1482-0047 286 µM 0.0469710760266086 0.484653688855188 no 1611 0.481268140031029 2332 3811116 SGTC_2803 7707263 71.43 µM 0.0464877486262802 0.484835051792215 no 1612 0.481460749355063 2291 2199229 SGTC_1721 st082152 9.2685 µM 0.0463068977549075 0.484902914768694 no 1613 0.481532820797724 2334 5296051 SGTC_2838 9002687 71.43 µM 0.0441449914110407 0.485714187730335 no 1614 0.482394414879954 2299 6457060 SGTC_1509 1326-1131 80 µM 0.043010989900802 0.486139754887986 no 1615 0.482846386643905 2312 768313 SGTC_1982 st072467 71.9 µM 0.0414729118912015 0.486716988675865 no 1616 0.483459443723908 2245 3163533 SGTC_541 4513-1321 94 µM 0.041124226762044 0.486847852556156 no 1617 0.483598430387351 2259 747515 SGTC_1275 0867-0008 21.1 µM 0.0409686120027689 0.486906256282587 no 1618 0.483660459418681 2280 3422836 SGTC_2814 7977482 42.97 µM 0.0384734949856682 0.487842735359877 no 1619 0.484655081885164 2323 6456762 SGTC_1326 1431-2094 10.8 µM 0.0379895946996986 0.488024363017373 no 1620 0.484847989133788 2336 616278 SGTC_1761 st044296 37 µM 0.0374758973475788 0.488217177454988 no 1621 0.485052778886983 2346 1826700 SGTC_1394 3474-0001 65.7 µM 0.0374522944533295 0.488226036782243 no 1622 0.485062188473669 2296 5017666 YIL048W NEO1 SGTC_2083 5306046 65.942 µM 0.0372224264252807 0.488312317863686 no 1623 0.485153828649702 2322 539837 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0364482855187186 0.488602896047053 no 1624 0.485462456729582 2342 803109 SGTC_2571 chrysanthemic acid 100 µM 0.0364188590688705 0.48861394155236 no 1625 0.485474188395666 2256 2743 An insecticide. SGTC_526 4469-0568 170 µM 0.036402749158747 0.488619988568141 no 1626 0.485480611061123 2332 2901964 SGTC_3062 9077494 49.47 µM 0.0346401051322567 0.489281630119364 no 1627 0.486183360702952 2300 16459633 SGTC_1744 st037937 38.9 µM 0.0320120973192136 0.490268156447469 no 1628 0.487231201788479 2316 1016152 SGTC_218 alverine citrate 93.75 µM 0.0318566200680383 0.49032652288722 no 1629 0.487293196618226 2329 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2101 5377231 179.231 µM 0.0306936726039514 0.490763101940677 no 1630 0.487756918658622 2310 2844213 SGTC_114 0364-0001 490.298 µM 0.0306272002725761 0.490788056483339 no 1631 0.487783424820428 2255 4003655 SGTC_1180 1193-0155 285 µM 0.0305480531659296 0.490817769341816 no 1632 0.487814985180197 2331 2921347 SGTC_2670 beta-carotene 100 µM 0.0298397121497545 0.491083692068145 no 1633 0.488097443570741 2358 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_168 3970-0862 530.542 µM 0.0286895742626731 0.491515480907137 no 1634 0.488556085739854 2306 3135186 SGTC_3231 9132313 49.47 µM 0.0275265827154386 0.491952105420516 no 1635 0.489019868968243 2293 4905967 SGTC_1132 3456-3614 2.5 µM 0.0274861644129203 0.491967279930491 no 1636 0.489035987439242 2359 3125502 SGTC_1522 st012842 45.6 µM 0.0273258916484893 0.492027452306074 no 1637 0.489099903013608 2356 3491067 YOR116C RPO31 SGTC_940 3232-1287 54.8 µM 0.0267434466008716 0.492246125425622 no 1638 0.489332180067767 2370 1585493 YIL048W NEO1 SGTC_1224 0823-0416 294 µM 0.0263150547783867 0.492406962306273 no 1639 0.489503023546532 2347 3598164 SGTC_627 1391-0720 175 µM 0.0242364099599698 0.493187392826194 no 1640 0.490332017852292 2325 997839 SGTC_3210 9128157 49.47 µM 0.0235894172064711 0.493430312751233 no 1641 0.490590056824846 2248 17590849 SGTC_890 0929-0006 47.2 µM 0.0232267733666147 0.493566472093075 no 1642 0.490734691153682 2350 1378169 SGTC_3141 9094609 49.47 µM 0.0227541959491168 0.493743908547533 no 1643 0.490923172445888 2337 25236309 YDL196W YDL196W SGTC_731 3966-0296 387 µM 0.0226609146561949 0.493778932589988 no 1644 0.490960376704482 2365 660956 SGTC_1730 st033808 45.1 µM 0.0226420484481563 0.4937860162334 no 1645 0.490967901301895 2269 1045166 SGTC_2373 9071805 200 µM 0.0224061681160418 0.493874581739719 no 1646 0.491061980071498 2376 10149009 SGTC_2966 9084041 48.03 µM 0.0205187498461184 0.494583257327817 no 1647 0.491814777505261 2376 17741380 SGTC_2075 5212009 200 µM 0.0203978464711444 0.494628653950414 no 1648 0.491863000880543 2359 780898 SGTC_2217 6934799 96.0675 µM 0.0197984609321468 0.494853711372682 no 1649 0.492102072821 2368 675606 SGTC_1676 st018489 23.4 µM 0.0196432750571689 0.494911980871117 no 1650 0.492163970990127 2300 3696235 SGTC_424 splitomicin 100 mM 0.0177350124101229 0.495628507585879 no 1651 0.492925124585647 2259 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2303 7774051 200 µM 0.0164974705803088 0.49609319542398 no 1652 0.493418759999405 2376 2953184 SGTC_2686 alizarin 95.37 µM 0.0162926858334308 0.496170091115535 no 1653 0.493500446313853 2363 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_856 0433-0016 11.3 µM 0.0152612157597496 0.496557405292531 no 1654 0.493911892108855 2336 3911780 SGTC_1091 telmisartan 47.6 µM 0.0152344264804887 0.496567464638059 no 1655 0.493922578242699 2344 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2769 toremifene 3.73 µM 0.0150452570141665 0.496638497630803 no 1656 0.493998037292202 2364 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1979 st071809 45.3 µM 0.0139886352667344 0.497035260201426 no 1657 0.494419523947287 2361 4976333 SGTC_2363 9053361 176 µM 0.0139508947829195 0.497049431849125 no 1658 0.494434578752886 2377 6469797 YMR079W SEC14 SGTC_982 1491-0518 27.5 µM 0.01360696466892 0.497178578651365 no 1659 0.4945717739917 2373 3091256 SGTC_994 3910-0338 138 µM 0.0126753611782001 0.497528400037662 no 1660 0.494943397909998 2379 3479481 SGTC_1030 k029-0042 36.7 µM 0.0123031404739002 0.497668171166825 no 1661 0.495091880904983 2304 6080581 SGTC_187 1488-2104 32.728 µM 0.0118466155157399 0.49783959944303 no 1662 0.495273994734444 2369 2852859 SGTC_2338 7999974 200 µM 0.0115382497780562 0.497955393135892 no 1663 0.495397006455609 2382 315925 SGTC_2408 sulbentine 18.36 µM 0.009878858281787 0.498578510046563 no 1664 0.49605896985147 2325 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_789 1309-1135 70.6 µM 0.00980855900841789 0.498604908163573 no 1665 0.496087013845148 2387 3092424 SGTC_2305 7443522 69.23 µM 0.00971831335644693 0.49863879636461 no 1666 0.496123014935392 2384 5415886 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0096930212880741 0.498648293806746 no 1667 0.496133104535593 2385 6708784 An antioxidant flavonoid SGTC_1949 st076024 69.1 µM 0.00934836651841975 0.498777715432427 no 1668 0.496270595663183 2389 2921930 SGTC_268 camptothecin 39.6153 µM 0.00902030999457796 0.498900904355441 no 1669 0.49640146576062 2388 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3289 9119912 71.43 µM 0.00900613874462038 0.498906225822004 no 1670 0.496407119041758 2383 17014829 SGTC_1947 st076332 61.6 µM 0.00843703730412795 0.499119930077457 no 1671 0.496634149030337 2391 24208416 SGTC_776 4476-4378 112 µM 0.00787903439554957 0.499329466949791 no 1672 0.496856752572617 2321 2892008 SGTC_1888 azatryptophan 97.5 µM 0.00613332223554013 0.499985004007349 no 1673 0.497553173781565 2339 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1474 0330-0125 5.35 µM 0.00609338753799836 0.5 no 1674 0.497569105123164 2398 X1474 SGTC_1632 st005650 90 µM 0.00532013916944756 0.499709635316028 no 1675 0.497877581559805 2383 2759605 SGTC_2251 lansoprazole 556 µM 0.0047726830006247 0.499504058584153 no 1676 0.498095982188546 2390 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_854 0422-0053 192 µM 0.0032625512532552 0.498936985816551 no 1677 0.498698432672133 2400 3596728 SGTC_1955 wogonin 32.4 µM 0.00320471316083545 0.498915266947495 no 1678 0.498721506611978 2396 5281703 A flavanone. SGTC_141 0443-0274 32.331 µM 0.00270268411817803 0.498726749408769 no 1679 0.498921786347325 2397 1627241 SGTC_877 0771-0151 33.1 µM 0.00263628066142932 0.498701814186034 no 1680 0.498948277399392 2383 6166523 SGTC_1076 itraconazole 331 nM 0.00229229575897116 0.498572644184269 no 1681 0.499085507103447 2401 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1845 st056753 3.01 µM 0.0013417349992479 0.498215699294402 no 1682 0.499464725340311 2397 5375839 SGTC_666 0272-0154 136 µM 0.00117701871902458 0.498153846852583 no 1683 0.499530437576577 2403 6870312 SGTC_2725 haloperidol 53.21 µM 0.000473863321956262 0.497889806206329 no 1684 0.499810955892815 2403 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_366 0181-0206 4.31 µM 0 0.497711867138148 no 1685 0.5 2406 274874 SGTC_2516 gossypol 71.55 µM 0 0.497711867138148 no 1686 0.5 2406 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1513 0337-0559 19 µM -0.000388589456297562 0.49756594935483 no 1687 0.499844975240066 2410 775073 SGTC_1574 spiramycin 23.7 µM -0.00211160300881639 0.496918951128116 no 1688 0.499157592906391 2407 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1620 st003704 16.5 µM -0.00309425581953844 0.49654996473178 no 1689 0.498765572497029 2402 2834414 SGTC_2278 7948257 134.34 µM -0.00457859551928655 0.495992600471169 no 1690 0.498173411044463 2417 1247028 SGTC_2290 7904846 200 µM -0.00523054854129095 0.495747796845962 no 1691 0.497913322551967 2424 2962154 SGTC_815 1582-0027 36.9 µM -0.00527247926147463 0.495732052218859 no 1692 0.497896594845502 2417 3128206 SGTC_2606 farnesol 9.78 µM -0.0058449199389073 0.495517106311626 no 1693 0.497668227587574 2420 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1205 4161-2785 76 µM -0.00620221102042039 0.495382947640969 no 1694 0.49752569165537 2436 3498106 SGTC_3279 9140807 49.47 µM -0.00640561385206511 0.495306572461398 no 1695 0.49744454727834 2419 45595718 SGTC_722 3534-0461 190 µM -0.00731131130500864 0.494966496699938 no 1696 0.497083234781358 2427 658262 SGTC_1986 st071812 45 µM -0.00770099757594534 0.494820176481669 no 1697 0.496927776832269 2426 11838594 SGTC_1272 0839-0021 27 µM -0.00820567095251618 0.49463068170235 no 1698 0.49672644765439 2433 5027250 SGTC_6 0844-0013 19.835 µM -0.00962627702641588 0.494097279121808 no 1699 0.496159730401295 2423 1584900 SGTC_917 harmaline 728.087 nM -0.0101398786253589 0.493904436922791 no 1700 0.495954843016902 2442 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2038 4100038 30.985 µM -0.0106732000321893 0.493704192027772 no 1701 0.49574209008166 2444 3596803 SGTC_513 4245-1575 41.7 µM -0.0107782980016839 0.493664731333612 no 1702 0.495700164469729 2449 719745 SGTC_2451 5856223 45.7 µM -0.0111223538002282 0.493535550580519 no 1703 0.495562914294606 2437 2179896 SGTC_2449 5812982 45.77 µM -0.0112150530448269 0.493500745416398 no 1704 0.49552593495306 2416 776185 SGTC_3026 9090633 49.47 µM -0.0118075592482532 0.493278282263076 no 1705 0.495289574841148 2429 25236842 SGTC_2031 5180455 200 µM -0.0127724197738186 0.492916018974428 no 1706 0.494904680266814 2428 29949 SGTC_1572 epiandrosterone 68.9 µM -0.013344206486018 0.492701340595937 no 1707 0.494676589822821 2426 441302 A steroid. SGTC_610 4215-0184 155 µM -0.0143405025985161 0.492327284465521 no 1708 0.49427916327361 2438 5605015 SGTC_2383 9036125 200 µM -0.0146152350860914 0.492224138220677 no 1709 0.494169572355067 2434 79580 SGTC_852 0418-0143 439 µM -0.0148872116128614 0.492122027192684 no 1710 0.494061081223997 2431 5369229 SGTC_1875 nocodazole 6 µM -0.01509411287582 0.492044348405586 no 1711 0.49397854883634 2435 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1146 3579-1023 7 µM -0.0180437528784182 0.490936972967615 no 1712 0.492801974667074 2475 X1146 SGTC_632 0781-2353 4.65 µM -0.0186760919631506 0.490699584401795 no 1713 0.492549750389139 2465 6811515 YHR007C ERG11 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0190733218922921 0.490550460642836 no 1714 0.492391306802044 2451 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1633 st005664 67.9 µM -0.0190772714922693 0.490548977933374 no 1715 0.492389731426262 2441 2063822 SGTC_2274 7947094 46.08 µM -0.019743842659199 0.490298744003959 no 1716 0.492123858101027 2438 2971028 SGTC_1656 st012921 11 µM -0.0198263137372366 0.490267784239498 no 1717 0.492090963340043 2449 6732821 SGTC_235 0330-0087 5 mM -0.0201328083784596 0.490152726214009 no 1718 0.491968714071762 2449 46494818 YHR062C RPP1 SGTC_1187 1391-0724 117 µM -0.021345318957869 0.489697558116381 no 1719 0.491485096381108 2458 6997986 SGTC_1772 st048439 82.2 µM -0.0215410448809016 0.489624085198749 no 1720 0.491407030984854 2464 2927068 YDL195W SEC31 SGTC_317 4495-0002 170 µM -0.0216755215204179 0.489573604654347 no 1721 0.491353395090907 2472 15991618 SGTC_2441 5730946 39.09 µM -0.022211632448289 0.48937235819793 no 1722 0.491139569264318 2468 1774275 SGTC_1221 2958-7315 257 µM -0.0231815702294642 0.4890082678086 no 1723 0.490752719742044 2477 4562705 SGTC_3125 9127534 49.47 µM -0.0240956609519138 0.488665149386944 no 1724 0.49038815218894 2452 1639235 SGTC_833 3852-0053 558 µM -0.025190614280113 0.488254152388318 no 1725 0.489951461650836 2473 3123681 SGTC_2107 5363541 170.161 µM -0.0258548685702635 0.488004826789513 no 1726 0.489686548831952 2448 244052 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0259841709192688 0.48795629413264 no 1727 0.489634981982783 2491 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2364 9055074 200 µM -0.0276374313459606 0.487335771326819 no 1728 0.488975663581026 2471 6470630 SGTC_2539 epi(13)torulosol 80 µM -0.0276599614688926 0.487327315241839 no 1729 0.488966678797274 2482 6708597 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.028922863342623 0.486853327690782 no 1730 0.488463055468703 2493 616764 SGTC_1035 k081-0041 55.2 µM -0.0291922293547737 0.486752232638872 no 1731 0.488355639335374 2458 731709 SGTC_1808 st050063 61.5 µM -0.0294089315537441 0.486670903322263 no 1732 0.48826922476857 2440 4011993 SGTC_1838 st055369 84.5 µM -0.0308363586511809 0.486135197478294 no 1733 0.487700022093885 2445 676036 SGTC_1113 artemisinin 1.17947 µM -0.0336220770102227 0.485089805044308 no 1734 0.486589258655454 2467 2240 An anti-malaria and mitochondrial poison. SGTC_788 1182-0090 188 µM -0.0338721820339421 0.484995953405927 no 1735 0.486489537987758 2605 5715185 SGTC_179 1273-0063 6.77 µM -0.034880585703326 0.484617559509273 no 1736 0.486087480778244 2473 3108139 SGTC_3120 9124077 49.47 µM -0.035248827047965 0.484479383877939 no 1737 0.485940664023124 2463 18774327 YGL155W CDC43 SGTC_2977 9011197 71.43 µM -0.0355858758706706 0.484352914286373 no 1738 0.485806285305837 2548 2704722 SGTC_423 5-fluorouracil 457 µM -0.0359714737220648 0.484208229752374 no 1739 0.48565255244989 2458 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1679 SEC14.276 6.7 µM -0.0377428536271684 0.483543597258028 no 1740 0.484946354034095 2487 1005053 YMR079W SEC14 SGTC_2119 5528445 120.635 µM -0.0377962956884271 0.483523546173478 no 1741 0.484925048938025 2519 791935 SGTC_1936 st074407 74.3 µM -0.0383739044767535 0.483306834098517 no 1742 0.484694783431762 2467 809813 SGTC_2706 st078239 82.5 µM -0.03863153097345 0.483210177230737 no 1743 0.48459208148391 2470 15434492 SGTC_138 0850-0259 40.9225 µM -0.0392710142228876 0.482970258794851 no 1744 0.484337158040943 2474 6813004 SGTC_1170 0310-0127 64.8 µM -0.0394690584130084 0.482895958717016 no 1745 0.48425821104787 2512 774975 SGTC_2647 atorvastatin 60.16 µM -0.0397699957920996 0.482783057423048 no 1746 0.484138248593955 2517 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3137 9097352 49.47 µM -0.0398539008599374 0.482751579389956 no 1747 0.484104801831783 2512 44120435 SGTC_2537 larixol 68.93 µM -0.040840761550254 0.482381354410736 no 1748 0.483711421716993 2475 6708759 SGTC_2310 7668677 200 µM -0.0413895274097574 0.482175489120472 no 1749 0.483492680780363 2519 2197143 SGTC_1492 4158-0558 28.5 µM -0.0418733054728418 0.481994007441948 no 1750 0.483299848437056 2533 3967268 SGTC_2412 st077135 33.4 µM -0.0423073110038864 0.481831200314547 no 1751 0.483126858583935 2701 13258915 SGTC_475 α-linolenic acid 10 µM -0.0434928006646451 0.481386506835051 no 1752 0.482654351667398 2543 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_635 k038-0028 24.7 µM -0.0441707056252472 0.481132225731984 no 1753 0.482384166389418 2512 4035102 SGTC_77 0828-0286 12.516 µM -0.0460300300691355 0.480434835715865 no 1754 0.481643157367925 2482 745345 SGTC_1903 st060211 78.3 µM -0.0489988807439841 0.479321412838046 no 1755 0.480460093953412 2484 688960 SGTC_1012 4112-3522 18 µM -0.0493019443276884 0.479207762319924 no 1756 0.480339335027288 2490 3112398 SGTC_2386 9075165 157.42 µM -0.0493832932090706 0.479177256327399 no 1757 0.480306921002194 2505 16452277 SGTC_2648 atorvastatin 78.68 µM -0.0494284832908982 0.479160310009407 no 1758 0.480288914757414 2495 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1520 flindersine 88 µM -0.0506503579867546 0.478702120370073 no 1759 0.479802067211244 2639 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2798 7813637 45.45 µM -0.0516443593462037 0.478329401471774 no 1760 0.479406036416041 2547 956368 SGTC_753 1322-0200 289 µM -0.0518218198811387 0.478262861399208 no 1761 0.479335334579082 2566 5403907 SGTC_2478 5763493 32.33 µM -0.0529509460984449 0.477839501872322 no 1762 0.478885496091963 2508 1365576 YLR208W SEC13 SGTC_2366 9070441 60.58 µM -0.0534406315241138 0.477655904821164 no 1763 0.478690416086788 2521 6837235 SGTC_1909 st060837 51.5 µM -0.0535572934339887 0.477612165637365 no 1764 0.478643941274751 2534 678937 SGTC_1987 st072290 61.9 µM -0.0537927765431638 0.477523878525512 no 1765 0.478550132335989 2554 54697379 SGTC_447 ml7 120 µM -0.0539707682668716 0.477457146763064 no 1766 0.478479226914596 2505 4216 Selective myosin light chain kinase inhibitor. SGTC_912 3474-0017 2.18 µM -0.0542085086197696 0.477368015331156 no 1767 0.478384520877875 2564 3360550 SGTC_2870 9038528 12.99 µM -0.0542531719411568 0.477351270694662 no 1768 0.478366728972692 2647 6463316 SGTC_2344 7990960 76.95 µM -0.0551798985313164 0.47700384254841 no 1769 0.477997571590517 2525 140813 SGTC_3234 9132280 49.47 µM -0.0553197009049839 0.476951432398584 no 1770 0.477941883572663 2561 17612295 SGTC_330 1488-0319 80.1 µM -0.0568157890185455 0.476390592944676 no 1771 0.477345968218327 2564 6846614 SGTC_2928 9011484 9.79 µM -0.0572758459354514 0.476218140480529 no 1772 0.477162730455568 2567 2994751 SGTC_3202 9113761 49.47 µM -0.0585699667827968 0.475733062910828 no 1773 0.476647316318612 2626 4798415 SGTC_646 4092-0839 27.3 µM -0.0586860281022769 0.475689561191082 no 1774 0.47660109405803 2546 877796 SGTC_1464 k208-0027 110 µM -0.0590890140356445 0.475538517590078 no 1775 0.476440604441409 2509 X1464 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0598693152453862 0.475246062047321 no 1776 0.476129859463993 2506 688803 SGTC_2799 7812892 81.82 µM -0.0599107710976663 0.475230524837348 no 1777 0.476113350605444 2555 20205235 SGTC_2246 7293507 91.5585 µM -0.0612708901403993 0.474720787798747 no 1778 0.475571736767201 2590 887656 SGTC_1644 st010134 20.9 µM -0.0613653406211836 0.474685391756098 no 1779 0.475534127247756 2528 3818134 SGTC_220 paclitaxel 373.376 µM -0.0625223619013349 0.474251805451395 no 1780 0.475073427276097 2546 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_337 1315-0038 354 µM -0.0648113186592247 0.47339412392217 no 1781 0.474162114706354 2547 1626437 SGTC_3348 9149464 3.537 µM -0.0648255636276911 0.473388786655798 no 1782 0.474156443711816 2507 1951442 SGTC_287 k060-0039 29.6 µM -0.0649799457722859 0.473330943476814 no 1783 0.474094983729492 2553 5861974 SGTC_2245 6637752 200 µM -0.0657973937651061 0.473024675291398 no 1784 0.473769565607909 2554 681890 SGTC_1058 3448-5425 97.3 µM -0.0692759624013953 0.471721561984629 no 1785 0.472384979492652 2519 7279705 SGTC_429 1112-0049 25.5 µM -0.0693051474955232 0.471710630161099 no 1786 0.472373364241604 2550 2836170 SGTC_276 colchicine 750 µM -0.069889085864984 0.471491909600104 no 1787 0.472140970052956 2634 2833 A microtubule depolymerizer. SGTC_161 4065-0411 162.148 µM -0.070774509341803 0.471160280888727 no 1788 0.471788609768033 2596 1906281 YLR208W SEC13 SGTC_1960 st011366 51.8 µM -0.0709723786302411 0.471086173158892 no 1789 0.47170986934989 2532 3972846 SGTC_3188 9110789 49.47 µM -0.0713493155103311 0.470945002246986 no 1790 0.471559873552779 2577 849217 SGTC_1749 st037932 54.2 µM -0.0719661480410686 0.470713993174472 no 1791 0.471314423960899 2622 594497 SGTC_673 1082-0474 110 µM -0.0732977914945382 0.470215314985096 no 1792 0.470784574553347 2538 3098046 SGTC_1316 1272-0050 65.9 µM -0.0734481092211669 0.470159026431248 no 1793 0.470724767661513 2547 7340392 SGTC_315 k915-0449 187 µM -0.0741734740967989 0.469887411912312 no 1794 0.470436176149935 2560 20970215 YNL149C PGA2 SGTC_1262 0737-0114 49.6 µM -0.0753328691530117 0.469453302956674 no 1795 0.469974934986378 2547 765919 SGTC_255 tunicamycin 200.472 nM -0.0757514488016652 0.469296584276614 no 1796 0.469808421660448 2552 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_348 k064-0012 10.7 µM -0.0759089999299512 0.469237597439267 no 1797 0.46974574830628 2507 5066323 SGTC_1406 3909-7906 11.9 µM -0.0760664807506188 0.469178637599701 no 1798 0.469683103669304 2557 X1406 SGTC_2277 7947813 106.88 µM -0.0766511912330455 0.46895973155623 no 1799 0.469450516997013 2772 1246798 SGTC_1508 1080-0625 72.9 µM -0.0788571541271808 0.468133940148758 no 1800 0.468573121559404 2515 767111 SGTC_671 0560-0003 407 µM -0.0790614247049152 0.468057479339432 no 1801 0.468491883028201 2642 3238678 SGTC_1256 0570-0116 285 µM -0.0792467699687841 0.467988103510738 no 1802 0.468418172240863 2573 410638 SGTC_1485 3909-9022 254 µM -0.081029558594431 0.467320845141017 no 1803 0.467709222714905 2542 714516 SGTC_594 1487-1584 10.8 µM -0.0811371925800248 0.467280563040042 no 1804 0.467666423889495 2559 5013332 SGTC_546 peri-Naphthalide 147 µM -0.0815757151810771 0.467116449091096 no 1805 0.467492056697451 2626 223824 A penicillin ester. SGTC_1381 2324-0066 62.1 µM -0.0819603757207247 0.466972497234904 no 1806 0.467339111497926 2627 10885928 SGTC_303 1348-1668 34.2 µM -0.0820575956450259 0.466936115219218 no 1807 0.467300456564809 2580 5380509 SGTC_333 3486-0131 40.1 µM -0.0832781811202357 0.466479366611891 no 1808 0.466815174482155 2685 6744690 SGTC_1868 st057644 42.7 µM -0.0838039097156833 0.466282650158833 no 1809 0.466606169727017 2542 688665 SGTC_2426 5582046 32.21 µM -0.0838164368009304 0.46627796289039 no 1810 0.466601189664154 2637 2251934 SGTC_3329 9141233 27.5565 µM -0.083851846087469 0.466264713797632 no 1811 0.466587112956353 2654 4909101 YNL103W MET4 SGTC_2596 sinensetin 100 µM -0.0848672216509406 0.465884806686919 no 1812 0.466183475538276 2602 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_150 3970-0969 77.2 µM -0.0852111199349393 0.465756142702896 no 1813 0.466046775153399 2692 6615640 SGTC_2565 isoliquiritigenin 100 µM -0.0853708031220866 0.46569640103567 no 1814 0.465983302068027 2686 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_531 3788-1495 174 µM -0.085843493871976 0.465519559568494 no 1815 0.465795415478322 2540 2896655 SGTC_3263 9137018 49.47 µM -0.0860905661261493 0.465427128438447 no 1816 0.465697211461403 2560 43844957 SGTC_2477 5967686 25.23 µM -0.0886975867735339 0.464451941880044 no 1817 0.46466112522684 2578 776118 SGTC_1345 1488-0192 31.4 µM -0.0889749312095663 0.464348210412614 no 1818 0.464550916541463 2581 658348 SGTC_232 clozapine 119 µM -0.0891636969081484 0.464277610263065 no 1819 0.464475908048253 2563 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_438 sphingosine 6.67 µM -0.0900550065299558 0.463944267298445 no 1820 0.464121751733655 2577 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_876 0720-0963 56.8 µM -0.0902492999783067 0.463871606390243 no 1821 0.464044554208693 2608 765861 SGTC_2541 muurolladie-3-one 83.07 µM -0.0904222793044535 0.463806917446562 no 1822 0.463975826443186 2727 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2183 6420625 130.508 µM -0.0919769909632703 0.463225546291672 no 1823 0.463358160319088 2558 2897619 SGTC_691 1548-0686 185 µM -0.0921215436289513 0.463171496027414 no 1824 0.463300735945414 2585 46495133 SGTC_327 1273-0057 3.96 µM -0.0953307276623227 0.46197171411346 no 1825 0.462026068322377 2622 3108138 SGTC_2773 thioridazine 9.09 µM -0.0955159155310689 0.461902490439695 no 1826 0.461952524645219 2553 5452 An antipsychotic. SGTC_1677 st019204 53.9 µM -0.0955827871558121 0.461877493947935 no 1827 0.461925968229633 2697 3945625 SGTC_2334 9017922 200 µM -0.0959051928607425 0.461756981396387 no 1828 0.461797935143958 2683 3163164 SGTC_1075 aripiprazole 15.2 µM -0.096996450480146 0.461349104560072 no 1829 0.461364606632836 2567 60795 An atypical antipschotic. YIL048W NEO1 SGTC_487 nimodipine 119 µM -0.0976622882944667 0.461100255842228 no 1830 0.461100230968073 2557 4497 L-type voltage-gated calcium channels inhibitor SGTC_2692 st077426 47.7 µM -0.0978731713406959 0.461021444061098 no 1831 0.461016501925873 2610 25238571 SGTC_2295 7971645 200 µM -0.0986522934863903 0.460730281730645 no 1832 0.460707174145956 2662 2978226 YKL099C UTP11 SGTC_728 3030-5151 22.5 µM -0.0998559965551595 0.460280492561217 no 1833 0.46022932566863 2585 3125388 SGTC_33 0986-0033 35.816 µM -0.0998819345190318 0.460270800848436 no 1834 0.460219029392968 2587 2848082 SGTC_158 k038-0087 26.446 µM -0.100606605118249 0.460000037448747 no 1835 0.459931376593916 2579 X158 SGTC_1658 st012944 20 µM -0.100839910298436 0.459912870054587 no 1836 0.459838772230655 2634 24207260 SGTC_1231 0242-0792 125 µM -0.101498083051192 0.459666974195044 no 1837 0.459577539602744 2581 3707635 SGTC_459 nigericin 15.3 µM -0.101632288303422 0.459616836489657 no 1838 0.459524274888849 2685 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1923 st058458 19.1 µM -0.103095650510892 0.459070181231043 no 1839 0.458943528509988 2674 3534982 SGTC_2104 5389443 200 µM -0.103763087046323 0.458820878510103 no 1840 0.458678680281557 2705 2244536 SGTC_1831 st055328 12 µM -0.104312357781686 0.458615725545702 no 1841 0.45846073566169 2605 1103068 SGTC_510 ag-490 170 µM -0.104475040428245 0.45855496558841 no 1842 0.458396187360907 2596 5328779 SGTC_313 3474-0040 5.03 µM -0.105558172858917 0.458150453769065 no 1843 0.457966456247488 2580 1043375 YIL048W NEO1 SGTC_607 4491-0986 66.8 µM -0.10657344672812 0.457771324076538 no 1844 0.457563692512986 2662 698981 YDR232W HEM1 SGTC_3084 9116877 49.47 µM -0.106642265810205 0.457745626626373 no 1845 0.457536393244363 2579 27241325 SGTC_1100 amiodarone 5.07 µM -0.10686520957998 0.457662379324554 no 1846 0.457447956913248 2598 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1103 duloxetine 36.1 µM -0.107139608397224 0.457559921235651 no 1847 0.457339112518469 2754 60835 A selective serotonin reuptake inhibitor. SGTC_1003 4049-0218 100 µM -0.108085299743959 0.457206830112759 no 1848 0.456964014470259 2716 295161 SGTC_2971 9092186 9.93 µM -0.108690445198817 0.456980905718629 no 1849 0.456724010291027 2608 25236400 SGTC_3064 1327-0027 10 µM -0.110000397347679 0.456491897223108 no 1850 0.456204529895041 2602 16000455 YPR107C YTH1 SGTC_3269 9137823 49.47 µM -0.111257084754842 0.456022834503055 no 1851 0.455706242734398 2585 17682936 SGTC_3293 9120939 62.045 µM -0.111549686287741 0.455913628787591 no 1852 0.455590233727521 2696 934087 SGTC_385 1494-0393 12.4 µM -0.11156070064565 0.455909518037361 no 1853 0.455585866890853 2634 3090647 SGTC_657 3534-0529 86.7 µM -0.112897363958604 0.455410687176681 no 1854 0.455055963113415 2728 1049549 SGTC_2141 5621638 7.665 µM -0.114620501145696 0.454767731525521 no 1855 0.454372964621366 2724 2856238 SGTC_2359 9039622 200 µM -0.114661573578034 0.454752407572816 no 1856 0.45435668641251 2631 6463596 SGTC_1988 st071872 53.4 µM -0.115105559334329 0.454586762647193 no 1857 0.454180726742119 2599 16414116 SGTC_2291 7917025 104.35 µM -0.115394396190069 0.454479005861811 no 1858 0.454066260242507 2630 2964612 SGTC_1663 st014140 55.4 µM -0.11544345472398 0.454460703855902 no 1859 0.454046818647228 2613 4207120 SGTC_2837 9008476 45.46 µM -0.116893621764169 0.453919741598142 no 1860 0.453472176298752 2797 2992805 SGTC_1970 st070122 35.8 µM -0.117637703692838 0.453642206526085 no 1861 0.453177364561395 2746 102928 SGTC_421 streptovitacin 30 mM -0.117939104837015 0.453529793366566 no 1862 0.453057954138465 2803 91467 include heat shock SGTC_3207 9114163 49.47 µM -0.119058036818341 0.4531124995229 no 1863 0.452614687987916 2758 849233 SGTC_2269 7935389 174.42 µM -0.119489389104945 0.452951645052325 no 1864 0.452443823038256 2603 97605 SGTC_1797 st048695 56.8 µM -0.120672367989029 0.452510543138209 no 1865 0.45197527308726 2679 592262 YIL048W NEO1 SGTC_2466 5983409 37.09 µM -0.120929863466208 0.452414537550828 no 1866 0.451873294061239 2672 2879657 SGTC_401 neomycin 50 µM -0.121175858378384 0.452322822476001 no 1867 0.451775872707884 2655 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_999 SEC7.066 22.7 µM -0.124096763943008 0.451234007634957 no 1868 0.450619330177242 2647 740511 YDR170C SEC7 SGTC_562 3772-2733 112 µM -0.124354952002474 0.451137781380357 no 1869 0.450517119753695 2676 2876874 YIL048W NEO1 SGTC_829 1635-0120 117 µM -0.12445911060656 0.4510989624567 no 1870 0.450475886803927 2762 285054 SGTC_619 1652-1634 108 µM -0.126520389901324 0.450330839899381 no 1871 0.44966000496459 2689 5400454 SGTC_1571 st070080 73.4 µM -0.127162723004766 0.450091516452676 no 1872 0.449405804272466 2751 4315245 SGTC_2022 5136654 200 µM -0.127595115943809 0.449930423701289 no 1873 0.449234698225751 2761 1713771 SGTC_2094 5332512 191.667 µM -0.127810270923337 0.449850268416518 no 1874 0.449149560854918 2747 755774 SGTC_2259 7964009 200 µM -0.130336262043179 0.448909372556581 no 1875 0.448150195893471 2815 313134 SGTC_2495 cafestol 54.53 µM -0.130523761904127 0.448839542905775 no 1876 0.448076027835261 2838 16667697 An anti-infammatory. SGTC_742 0kpi-0133 140 µM -0.132809225626541 0.447988506924811 no 1877 0.447172129001248 2770 2728852 SGTC_1366 1683-0113 21.9 µM -0.132838503461673 0.447977606309179 no 1878 0.447160551413635 2647 708623 SGTC_705 1124-0212 310 µM -0.1330564298845 0.447896469981911 no 1879 0.44707437629869 2636 9554485 SGTC_643 k048-0106 28.4 µM -0.133074260172956 0.447889831672124 no 1880 0.447067325739836 2757 6763920 SGTC_2999 9069765 71.4286 µM -0.135547897985174 0.446969025633543 no 1881 0.446089348274642 2720 2097066 SGTC_2944 9067346 25.62 µM -0.136221924652185 0.446718170083872 no 1882 0.445822921678492 2773 6473075 SGTC_1635 st007035 42.4 µM -0.138148757834749 0.446001169794227 no 1883 0.445061425996222 2629 3716403 SGTC_397 arbidol 50 µM -0.138653629275446 0.445813329500942 no 1884 0.444861931263183 2800 131410 A RNA synthesis inhibitor. SGTC_2435 5706476 10.6 µM -0.141793256688331 0.444645487848489 no 1885 0.443621655317458 2735 5725375 SGTC_2138 5575593 77.673 µM -0.142333212129206 0.444444689706817 no 1886 0.443408407043392 2649 762213 SGTC_2109 5483026 200 µM -0.143516439251246 0.444004722197609 no 1887 0.442941164498695 2704 759335 SGTC_2131 toluylene red 5.2905 µM -0.144497281839292 0.44364006100937 no 1888 0.442553901352773 2696 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_86 0417-1630 471.922 µM -0.144835757946834 0.443514232203057 no 1889 0.442420274562411 2650 3634867 SGTC_1550 gossypolone 36.6 µM -0.145337671021988 0.443327656040367 no 1890 0.442222136647774 2675 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3160 9100216 49.47 µM -0.14703428703116 0.442697066172194 no 1891 0.44155247864225 2627 17191039 SGTC_3326 9140064 16.379 µM -0.147892520098224 0.44237813751713 no 1892 0.44121379569476 2654 1868434 SGTC_182 3448-4371 550.524 µM -0.148433571560018 0.442177096141848 no 1893 0.441000303620606 2647 3491403 SGTC_29 0299-0004 12.984 µM -0.14862489682583 0.442106007954529 no 1894 0.440924813187031 2656 16871 A napthoquinone isolated from Swertia calycina. SGTC_3013 9080133 71.4286 µM -0.14954375209489 0.441764627126507 no 1895 0.440562294150664 2845 17050193 SGTC_1927 st060202 13.8 µM -0.149698539960569 0.441707123288313 no 1896 0.440501230071364 2631 688887 SGTC_1557 sumaresinolic acid 42.3 µM -0.150597793895543 0.44137307394248 no 1897 0.440146500880313 2666 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1545 lovastatin 49.4 µM -0.151327984175863 0.441101857994702 no 1898 0.439858497647159 2718 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_122 0236-0016 402.397 µM -0.153820145507513 0.440176398590419 no 1899 0.438875774530174 2694 6808838 SGTC_1954 st077032 68.9 µM -0.154966807009998 0.439750697451177 no 1900 0.438423742654565 2758 698907 SGTC_1281 0884-0031 11.8 µM -0.155497592972032 0.4395536653011 no 1901 0.438214525696023 2681 1548255 SGTC_3004 9076122 71.4286 µM -0.156780169238475 0.43907762424981 no 1902 0.437709051107549 2806 44782551 SGTC_1125 tnp00248 1.32998 µM -0.156971283780948 0.439006697694917 no 1903 0.437633739865863 2847 24207736 SGTC_2812 7970281 58.44 µM -0.157010226539114 0.438992245472959 no 1904 0.437618394228132 2812 2233435 SGTC_367 0335-0881 7.1 µM -0.157059793639837 0.438973850521139 no 1905 0.437598862137404 2822 23828853 SGTC_2771 fluoxetine 41.05 µM -0.157518170446361 0.438803747582981 no 1906 0.437418244352328 2854 3386 A selective serotonin reuptake inhibitor. SGTC_225 nsc-122657 1.016 µM -0.158259018344031 0.438528843960049 no 1907 0.437126349869057 2793 275685 SGTC_2304 7443016 91.4 µM -0.158951598123898 0.438271877821585 no 1908 0.436853503997577 2654 939854 SGTC_1931 st074438 57.1 µM -0.158958741736254 0.438269227480419 no 1909 0.436850689885815 2635 2787313 SGTC_2972 9093619 59.92 µM -0.159845853866587 0.437940122864623 no 1910 0.43650125114204 2709 25236256 SGTC_2964 9083345 53.42 µM -0.16009019230474 0.437849484685172 no 1911 0.436405013469639 2727 17741579 SGTC_659 k018-0002 107 µM -0.160446165698516 0.437717440974042 no 1912 0.436264812833981 2770 6797879 YHR007C ERG11 SGTC_249 wiskostatin 11.211 µM -0.160511886500237 0.437693063453454 no 1913 0.436238929476345 2681 2775510 A n-wasp and actin depolymerizer. SGTC_1834 st055981 52.8 µM -0.160809228955451 0.437582774514233 no 1914 0.436121828093666 2851 471719 YDL150W RPC53 SGTC_201 4262-0159 12.803 µM -0.161161627721531 0.437452070613243 no 1915 0.435983051319598 2795 1341029 SGTC_46 0329-0187a 2.197 µM -0.164536240783161 0.436200781957758 no 1916 0.434654509736481 2773 46494817 SGTC_133 0724-0033 378.92 µM -0.166422830843037 0.435501521689447 no 1917 0.433912104034756 2669 280309 SGTC_2921 7974240 10.71 µM -0.166842179617353 0.435346118342187 no 1918 0.433747114633937 2833 2979074 YDR527W RBA50 SGTC_807 1315-0151 48 µM -0.167189981084719 0.435217236753645 no 1919 0.433610283701045 2803 4011080 SGTC_53 0973-0023 39.979 µM -0.167552615725403 0.435082865901019 no 1920 0.433467625621697 2695 674768 SGTC_2674 ligustilide 100 µM -0.168051056286096 0.434898185679444 no 1921 0.433271556536108 2790 5319022 A signalling regulator. SGTC_453 enantio-paf c16 10 µM -0.171039799138393 0.433791107796166 no 1922 0.432096235740907 2806 13871343 A lipid and platelet activating factor SGTC_1141 3253-0389 52.6 µM -0.171553247309991 0.433600970445739 no 1923 0.431894382823745 2691 5402031 SGTC_2432 5630864 12.22 µM -0.171717884437466 0.433540006166183 no 1924 0.431829662459122 2849 5714970 SGTC_800 3448-7362 155 µM -0.172241914263961 0.433345971155906 no 1925 0.431623673717229 2777 15991913 SGTC_1439 4092-1168 46 µM -0.172389387411301 0.433291368468629 no 1926 0.431565707450604 2716 2886240 SGTC_135 0933-0004 26.348 µM -0.17326149078436 0.43296849379762 no 1927 0.431222945877325 2810 21230617 YGL099W LSG1 SGTC_3211 9128781 49.47 µM -0.174604476848028 0.432471374049694 no 1928 0.430695215305971 2857 17194361 SGTC_1652 st011932 78 µM -0.174907617614621 0.432359178214364 no 1929 0.430576112278108 2789 1551076 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.175110974693962 0.432283916509291 no 1930 0.430496217476967 2829 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3126 9127922 49.47 µM -0.179244214113252 0.430754756074262 no 1931 0.428872974006508 2979 45595682 SGTC_1387 3342-1166 1.8 µM -0.180198653734627 0.430401791948809 no 1932 0.428498307648668 2812 3418228 SGTC_332 4112-0506 40.9 µM -0.180448838943801 0.430309279406225 no 1933 0.428400107805548 2731 2790355 SGTC_58 0957-0393 9 µM -0.181152749031837 0.430049010727981 no 1934 0.428123840853615 2742 6997992 SGTC_293 4049-0273 38.5 µM -0.182117217891572 0.429692450583403 no 1935 0.427745368381592 2749 1380311 SGTC_210 3551-0445 56.827 µM -0.182609960270605 0.429510307878628 no 1936 0.427552034297631 2871 2865180 YOR207C RET1 SGTC_14 0354-0009 295 µM -0.182671784779703 0.429487455446704 no 1937 0.427527777849225 2681 1713507 SGTC_2017 5132927 60.65 µM -0.182709259517391 0.429473603629786 no 1938 0.427513075010325 2745 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2721 ifenprodil 61.44 µM -0.183566036650472 0.429156936140483 no 1939 0.427176954563577 2874 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1429 4049-0205 9.46 µM -0.184101211388524 0.428959157013732 no 1940 0.426967028086269 2720 22774478 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.184151383500191 0.428940616326432 no 1941 0.426947348742464 2755 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3027 9089541 49.47 µM -0.185654452621754 0.428385242500892 no 1942 0.426357874391577 2819 9943819 SGTC_2933 9026794 32.47 µM -0.18628812218654 0.428151148331837 no 1943 0.426109410776118 2785 17586027 SGTC_1916 st067606 49.2 µM -0.18682156899861 0.42795409867561 no 1944 0.425900267516534 2846 19590279 SGTC_1653 st012112 65 µM -0.187275503499833 0.427786434179433 no 1945 0.425722314280253 2889 720429 SGTC_3055 9094636 49.47 µM -0.187452122474824 0.427721202008998 no 1946 0.425653079482434 2899 25236176 SGTC_2447 5741742 33.78 µM -0.187840876747296 0.427577627088728 no 1947 0.425500695534372 2820 1776504 SGTC_2247 cerulenin 830 nM -0.187930672113775 0.427544465182274 no 1948 0.425465499116582 2964 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_280 3448-3607 3.04 µM -0.191200754115927 0.426337157100865 no 1949 0.42418415640806 2813 626179 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.191864084593471 0.4260923405553 no 1950 0.423924335536216 2844 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_85 0868-0259 160.055 µM -0.192197449237825 0.425969315827372 no 1951 0.423793771935012 2808 83173 SGTC_1094 duloxetine 25.4 µM -0.192493674769664 0.425860002944936 no 1952 0.423677761035066 2733 60834 A selective serotonin reuptake inhibitor. SGTC_1024 4507-0395 26 µM -0.193705490056487 0.425412879357952 no 1953 0.423203246412231 2917 4201836 SGTC_868 0527-0199 213 µM -0.193962774814433 0.425317961302976 no 1954 0.423102514857168 2785 2849450 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.193996556858561 0.42530549867882 no 1955 0.42308928895974 2777 279621 SGTC_1855 st056195 39.6 µM -0.194043704932651 0.425288105281616 no 1956 0.423070830316614 2933 4028379 SGTC_1443 4112-3303 14 µM -0.194051865795961 0.425285094672088 no 1957 0.423067635325979 2759 704433 SGTC_124 0136-0217 7.121 µM -0.194649134011111 0.4250647693589 no 1958 0.422833817643214 2843 3976905 SGTC_1720 st037298 9.481 µM -0.195530553254364 0.424739666801814 no 1959 0.422488810612094 2844 597396 SGTC_2954 9074818 52.69 µM -0.195921329396026 0.424595549345338 no 1960 0.422335871175017 2889 16648742 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.196463781297158 0.424395510884569 no 1961 0.422123589273481 2743 756377 SGTC_1165 k072-0275 30.3 µM -0.196693796666275 0.424310694640558 no 1962 0.422033582405036 2782 6153523 YGL055W OLE1 SGTC_2224 6650123 117.647 µM -0.196748402923084 0.424290559554655 no 1963 0.422012215134419 2747 2908370 SGTC_291 SEC14.278 35.5 µM -0.196956938423983 0.42421366761659 no 1964 0.421930617907878 2849 1068044 SGTC_2480 5767542 37.17 µM -0.197968493970616 0.423840724308625 no 1965 0.421534857010701 2803 2867358 SGTC_923 1900-2434 73.3 µM -0.198072589507687 0.42380234992106 no 1966 0.421494135172975 2736 5910570 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.198153061389281 0.423772684791197 no 1967 0.421462655408331 2756 97141 SGTC_759 3486-0358 89.3 µM -0.198290151956712 0.423722148761181 no 1968 0.421409028157659 2835 875103 SGTC_1410 3909-8106 77.9 µM -0.198885599670989 0.4235026619876 no 1969 0.421176117144242 2821 1039210 SGTC_154 3389-1638 511.116 µM -0.199560068745055 0.423254075981835 no 1970 0.420912330026888 2859 5238686 SGTC_2927 9011802 47.9 µM -0.199979778614804 0.423099400832904 no 1971 0.420748198001829 2877 43912568 SGTC_1011 4112-3381 17.4 µM -0.200794730414322 0.422799101544683 no 1972 0.420429541768215 2930 2877139 SGTC_2784 7567673 72.73 µM -0.201607586231225 0.422499619281957 no 1973 0.420111757028586 2712 3471247 SGTC_2697 mebhydrolin 72.4 µM -0.202089609555509 0.422322047511193 no 1974 0.419923335329187 2889 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2640 pentamidine 10.38 µM -0.206576241535507 0.420669986624116 no 1975 0.418170408271116 2881 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1779 st039427 55 µM -0.207184436371638 0.420446144856395 no 1976 0.417932910794293 2827 1124498 SGTC_2151 5563267 85.4165 µM -0.209917455985155 0.41944059502547 no 1977 0.416866048928045 2815 5310824 SGTC_550 4123-0385 25.7 µM -0.210741010147575 0.41913769058441 no 1978 0.416544685850992 2777 5731123 SGTC_166 k072-0058 166.424 µM -0.212630320845403 0.418442980661482 no 1979 0.415807659795045 2814 5846229 SGTC_954 1189-0853 2.85 µM -0.212857179778125 0.418359580445161 no 1980 0.415719181267528 2736 2828194 SGTC_286 k060-0067 22.9 µM -0.213622601373032 0.418078215381929 no 1981 0.415420686439989 2804 5985051 SGTC_2154 5570129 200 µM -0.213660151023235 0.418064413400146 no 1982 0.415406044292113 2760 673366 SGTC_907 3448-6986 75.5 µM -0.214646115034654 0.417702042526458 no 1983 0.415021618604409 2941 590582 SGTC_1131 3454-3128 32.3 µM -0.215318814175493 0.417454845816912 no 1984 0.414759381019204 2961 710982 SGTC_850 0388-0143 75.9 µM -0.2174746409654 0.416662864525746 no 1985 0.413919233831007 2804 67273 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.217783960613194 0.416549258119503 no 1986 0.413798721098922 2890 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3195 9113082 49.47 µM -0.218063629341248 0.416446547853414 no 1987 0.413689767525223 2817 17018038 SGTC_2841 9004761 38.96 µM -0.218208407228839 0.416393379417836 no 1988 0.413633367446009 2807 2991039 SGTC_1368 1852-0141 284 µM -0.218371881143815 0.416333346865637 no 1989 0.41356968623182 2908 2838987 SGTC_2160 5660466 132.927 µM -0.218658668621801 0.416228034569853 no 1990 0.413457973749607 2751 2859134 SGTC_2704 st078022 71.1 µM -0.21893393665788 0.416126958027518 no 1991 0.41335075503045 2945 54697681 SGTC_2623 humulene 100 µM -0.21906789988243 0.416077769652892 no 1992 0.413298577806148 2869 6187145 An anti-inflammatory. SGTC_25 0118-0223 35.662 µM -0.219162238598869 0.416043131322276 no 1993 0.413261834817157 2929 5333628 SGTC_1915 st067105 30.6 µM -0.219771726479354 0.415819361488324 no 1994 0.413024470150083 2755 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_449 xestospongin c 11.1929 µM -0.22103641706913 0.415355125041573 no 1995 0.412532038729118 2925 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_376 3970-0862 59.1 µM -0.221066755797711 0.41534398989765 no 1996 0.412520227453546 2910 3135186 SGTC_479 n-linoleoylglycine 10 µM -0.221288853841327 0.415262475906934 no 1997 0.41243376410772 2815 6433346 An anti-infammatory. SGTC_1525 8-methoxypsoralen 92.5 µM -0.222726129408073 0.414735058151406 no 1998 0.411874331899881 3073 4114 Related to psoralen; DNA damaging agent. SGTC_2467 5474540 200 µM -0.222746002411739 0.414727766696413 no 1999 0.411866597963245 2789 5413519 SGTC_1227 3909-8010 46.6 µM -0.223177221300578 0.414569558641506 no 2000 0.411698789816501 2816 15982272 SGTC_979 1426-2828 121 µM -0.223740797397007 0.414362811510646 no 2001 0.411479499421369 2935 747872 SGTC_398 bronopol 33.3 µM -0.225034867215867 0.413888173617158 no 2002 0.410976074856039 2772 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2316 5844804 197.44 µM -0.225547565886541 0.413700161154103 no 2003 0.410776663127239 2928 776813 SGTC_2195 6536160 144.242 µM -0.225921685474741 0.413562979706503 no 2004 0.410631165627652 2798 3834386 SGTC_2879 9041815 71.43 µM -0.226524967174103 0.4133417917675 no 2005 0.410396571429177 2866 4942971 SGTC_1641 st009299 47.1 µM -0.227062539205409 0.413144718869275 no 2006 0.410187556325681 2815 4046054 SGTC_736 0958-0254 92.6 µM -0.227469763572298 0.412995445745186 no 2007 0.410029239094561 2923 6812352 SGTC_1450 4112-4260 37.6 µM -0.229521676756895 0.41224348340813 no 2008 0.409231737326906 2948 1633175 SGTC_1466 k213-0079 57.5 µM -0.22997487616007 0.412077443252093 no 2009 0.409055646216182 2808 3657981 SGTC_189 3970-0742 2.116 µM -0.230306152739388 0.411956082317033 no 2010 0.408926939956937 2831 2891807 SGTC_2626 ethyl orsellinate 100 µM -0.231454234562276 0.411535555532416 no 2011 0.408480967840206 2798 75653 A natural product. SGTC_1085 doxorubicin 7.67 µM -0.234052556692774 0.410584201305798 no 2012 0.407472088620308 2914 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_702 1488-0190 94 µM -0.234423065801984 0.41044858515834 no 2013 0.407328276774916 2897 949357 SGTC_1280 0880-0253 10.1 µM -0.234758975069148 0.410325642722954 no 2014 0.40719790553476 2849 6836607 SGTC_1104 tacrolimus 29.8 µM -0.23582270781054 0.409936375862301 no 2015 0.406785123378271 2830 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1382 3002-2117 298 µM -0.236922946495362 0.409533843228238 no 2016 0.40635828399797 2957 1497314 SGTC_2419 paclitaxel 166.5 µM -0.237665257190154 0.409262315743189 no 2017 0.406070366181077 2756 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2236 dapsone 200 µM -0.237770091824426 0.409223972118102 no 2018 0.406029708376302 2849 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_796 1234-0020 70.7 µM -0.23824846600234 0.409049016159632 no 2019 0.405844194353349 2811 46495034 SGTC_1794 st048918 76.9 µM -0.23861517055426 0.40891491343879 no 2020 0.405702000245091 2807 672303 SGTC_1108 betulinic acid 729.144 nM -0.238922907787997 0.408802383110941 no 2021 0.405582681025677 2864 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1523 st012844 44.7 µM -0.238929573918876 0.408799945588851 no 2022 0.405580096458116 2950 4274103 SGTC_2983 9022671 12.99 µM -0.239343303467672 0.40864866910025 no 2023 0.405419694831161 3030 6405161 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.23964322687197 0.408539013312481 no 2024 0.405303425412324 3037 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1581 himbacine 57.9 µM -0.241050019842496 0.408024767713967 no 2025 0.404758174519126 2823 5281825 An alkaloid muscarinic receptor antagonist. SGTC_272 doxorubicin 8.13 µM -0.242569318044676 0.407469574349634 no 2026 0.404169526027924 2809 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2800 7887935 81.82 µM -0.242645222013335 0.40744184181544 no 2027 0.404140122893143 3020 2961002 SGTC_211 3455-0679 143.504 µM -0.243749736257292 0.407038345262644 no 2028 0.403712325445192 2910 748649 SGTC_669 0108-0021 26.2 µM -0.244425616348388 0.40679148417907 no 2029 0.403450602173067 2889 17201 SGTC_2436 5633522 8.09 µM -0.244637864951233 0.406713969306467 no 2030 0.403368421362928 2986 5724242 SGTC_1259 0671-0132 43 µM -0.246028220932035 0.406206290796026 no 2031 0.402830193323884 2858 X1259 SGTC_402 epigallocatechin gallate 10 µM -0.24760913384019 0.405629223374267 no 2032 0.402218421492546 2865 65064 An antioxidant. SGTC_1079 idarubicin 2.36 µM -0.249366019411869 0.404988162704774 no 2033 0.401538833808538 2894 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2508 celastrol 40.54 µM -0.252106452583477 0.403988729995864 no 2034 0.400479391290641 2864 122724 Celastrol is a natural product and antioxidant. SGTC_2657 nystatin 74.44 µM -0.253104845150023 0.403624772753034 no 2035 0.400093597435328 2910 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1208 2323-2347 50.3 µM -0.253866546156403 0.40334715590945 no 2036 0.399799330280733 3013 5412760 SGTC_3107 9121808 49.47 µM -0.254153274658385 0.40324266470291 no 2037 0.399688573489414 2839 662681 SGTC_23 0213-0011 39.996 µM -0.254704763927122 0.40304170732219 no 2038 0.399475568248167 3029 627608 SGTC_3033 9090887 49.47 µM -0.256457159522301 0.402403321437353 no 2039 0.398798928111608 2864 19325384 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.256667215411685 0.402326816925434 no 2040 0.398717841081609 2832 6312947 SGTC_2129 girgensonine 121.053 µM -0.256942791329599 0.402226455020242 no 2041 0.398611468248785 2932 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3132 9126706 49.47 µM -0.258407223150638 0.401693232348438 no 2042 0.398046321296737 3075 850858 SGTC_463 ikarugamyin 104 µM -0.259634784494598 0.401246398869505 no 2043 0.397572751029561 2880 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_577 r071-0003 38.6 µM -0.260376292546408 0.400976551762203 no 2044 0.397286764123795 2874 4568517 YMR134W ERG29 SGTC_2811 7967822 32.47 µM -0.263564637170069 0.399816799902789 no 2045 0.396057705333368 3022 2232244 SGTC_1119 parthenolide 318.541 nM -0.264309005907765 0.399546164552193 no 2046 0.395770910627375 3081 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1606 st000094 49.2 µM -0.264332228205976 0.399537722234344 no 2047 0.395761964312342 3004 1242210 SGTC_386 1509-0011 3.07 µM -0.265016309044248 0.3992890501135 no 2048 0.395498449044264 2868 3107280 SGTC_2114 5491910 81.25 µM -0.265651758366776 0.399058092771657 no 2049 0.395253709950516 2995 2849228 SGTC_1972 st070201 17.4 µM -0.26874702886066 0.397933607338399 no 2050 0.394062179423964 3020 2829099 SGTC_1156 4092-0367 4.88 µM -0.269610110399068 0.397620207833677 no 2051 0.393730110663944 2906 1357585 SGTC_1073 triclabendazole 3.09 µM -0.26969384782787 0.397589804869698 no 2052 0.393697896976853 2951 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3332 9141069 11.198 µM -0.270007482890914 0.39747593736004 no 2053 0.393577248416135 2860 17332883 SGTC_2873 9040596 71.43 µM -0.27131913507694 0.396999827183105 no 2054 0.393072795292401 2994 6463863 SGTC_2521 angolensin 13.4 µM -0.271846415396889 0.396808475501267 no 2055 0.392870057156031 3032 821428 A flavenoid. SGTC_623 k072-0108 16.9 µM -0.274455014214019 0.395862173151803 no 2056 0.391867485080484 2960 5382803 SGTC_530 4358-1714 28 µM -0.275191471892539 0.395595124576333 no 2057 0.391584569285336 2986 1564641 SGTC_2418 pentamidine 31.67 µM -0.279426271446157 0.394060489194505 no 2058 0.389958855994054 2951 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2076 5212012 200 µM -0.2802142620954 0.393775112440161 no 2059 0.389656562622314 2858 604802 SGTC_1906 st060206 94.7 µM -0.280343551227607 0.39372829484925 no 2060 0.389606970372655 3048 5133468 SGTC_716 1683-5115 658 µM -0.281992160523997 0.393131442867243 no 2061 0.388974760736617 2873 723597 SGTC_939 1165-0479 45.3 µM -0.282436446161225 0.392970639429272 no 2062 0.388804436024682 3031 1377347 SGTC_1976 st070609 63.5 µM -0.282879973434458 0.392810128686794 no 2063 0.388634423361636 2831 682556 SGTC_2825 7998094 58.44 µM -0.285365262939467 0.391911050309764 no 2064 0.387682158862069 2970 2987815 SGTC_3185 9108267 49.47 µM -0.286066005477997 0.391657653727027 no 2065 0.387413783856125 2987 4910486 SGTC_1217 1183-1422 255 µM -0.286810851974011 0.391388359035793 no 2066 0.387128576605724 3046 2849664 SGTC_1824 st053723 68.6 µM -0.286866678368033 0.391368177439956 no 2067 0.387107202717581 2967 675225 SGTC_3025 9087895 49.47 µM -0.28796172465483 0.390972370446533 no 2068 0.386688018756394 3052 17173641 SGTC_650 1328-0195 38 µM -0.288042046224659 0.390943342470568 no 2069 0.386657276838593 2999 2780821 SGTC_1771 st048882 4.1505 µM -0.288241367081986 0.390871311131784 no 2070 0.386580992739374 2899 4580403 SGTC_2940 9060638 45.86 µM -0.288487775860724 0.390782268154121 no 2071 0.386486693204195 3010 4027022 SGTC_1071 trifluoperazine 6.31 µM -0.288934197358333 0.390620962599081 no 2072 0.386315866774511 3063 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2397 5161689 200 µM -0.290472016864481 0.390065446273738 no 2073 0.385727577836511 3128 2259942 SGTC_908 3448-7491 47.7 µM -0.290685226739254 0.38998844480402 no 2074 0.385646035650549 2904 1203031 SGTC_64 000l-0018 272.079 µM -0.291228816436063 0.389792145080005 no 2075 0.385438162468973 2876 6811119 SGTC_709 3807-1509 243 µM -0.291304394423832 0.389764854774472 no 2076 0.385409263427644 2911 1886677 YPL242C IQG1 SGTC_2052 5265182 7.135 µM -0.291342392672492 0.38975113426761 no 2077 0.385394734133783 3076 1239884 SGTC_1078 idebenone 36.1 µM -0.291511841885876 0.389689950775754 no 2078 0.385329944226513 2988 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1877 wortmannin 25 µM -0.29228589297819 0.389410496812801 no 2079 0.385034021946683 3061 312145 A covalent inhibitor of PI 3-kinase. SGTC_1854 st056233 32.9 µM -0.294769199915964 0.388514340626802 no 2080 0.384085098227391 3022 5393174 SGTC_1863 st057641 20.1 µM -0.295062033700636 0.388408704084816 no 2081 0.383973245953981 2935 3921635 SGTC_2730 imipramine 71.33 µM -0.295693525686523 0.388180928450664 no 2082 0.383732070984051 2939 3696 A tricyclic antidepressant. SGTC_1781 st038725 66.3 µM -0.295777853444243 0.388150514808139 no 2083 0.383699868527136 2934 4270275 YIL048W NEO1 SGTC_2173 5763948 167 µM -0.296510920588597 0.387886155787513 no 2084 0.383419964160472 2892 2867177 SGTC_1446 4239-0190 62 µM -0.29727971095244 0.387608970055474 no 2085 0.383126485082061 2954 1340085 SGTC_614 0462-0418 107 µM -0.298236628746634 0.387264035401959 no 2086 0.382761283691477 2973 5188303 SGTC_2717 st081029 62.2815 µM -0.298466583747201 0.387181158097457 no 2087 0.382673538394572 3037 5292846 SGTC_2144 5628481 200 µM -0.299648109370218 0.386755409609181 no 2088 0.382222791691018 2943 2818399 SGTC_1813 st051246 8.6015 µM -0.299853301589833 0.386681484942432 no 2089 0.382144528028194 3038 5291959 SGTC_1681 tripelennamine 100 µM -0.301820518750128 0.385972964020487 no 2090 0.381394444095181 2956 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2585 alliin 100 µM -0.303859295433776 0.385239071095205 no 2091 0.38061754494592 3132 87310 A garlic compound which reacts with lipids. SGTC_3305 9127027 53.8275 µM -0.30653788476049 0.384275491307034 no 2092 0.379597569666333 2967 41905295 SGTC_1765 st044815 90.4 µM -0.309639365277398 0.38316067632576 no 2093 0.378417608666209 3036 645695 SGTC_2749 bexarotene 57.39 µM -0.310307346509603 0.382920699335212 no 2094 0.37816362250377 3051 82146 An retinoic acid receptor inhibitor. SGTC_1191 1487-1166 10.6 µM -0.311239675108785 0.382585828822461 no 2095 0.377809211710493 3062 3955771 SGTC_2996 9066192 71.4286 µM -0.311991504815699 0.382315853181671 no 2096 0.377523489755583 2998 6472854 SGTC_2994 9053520 71.4286 µM -0.312008513902475 0.382309746024729 no 2097 0.377517026473951 3089 4647384 SGTC_2460 5552655 174.22 µM -0.312352767053074 0.382186147328149 no 2098 0.377386221119307 3086 5401989 SGTC_370 0180-0345 38.7 µM -0.314230008530883 0.381512364725601 no 2099 0.376673176308434 2875 3989527 SGTC_1176 0848-0131 83.3 µM -0.315324049178259 0.381119855251815 no 2100 0.376257813543807 3040 6769040 SGTC_1833 st055984 71 µM -0.315678719119045 0.380992636376943 no 2101 0.376123190512329 2986 676288 SGTC_1583 clindamycin 39.6 µM -0.315971250383527 0.380887716108455 no 2102 0.376012164968306 2959 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3306 9127676 59.7925 µM -0.317200847507864 0.380446800432289 no 2103 0.375545603442157 3042 41905287 SGTC_3271 9137798 49.47 µM -0.318015980244598 0.380154591215808 no 2104 0.375236407603947 3081 6498326 SGTC_1668 st014914 51.6 µM -0.318120294849245 0.380117201393677 no 2105 0.375196844808256 3031 2839556 SGTC_1339 1486-1321 22.7 µM -0.318301752148116 0.380052163735084 no 2106 0.375128027678296 2986 3469382 SGTC_188 3229-0966 278.469 µM -0.318326773256913 0.380043195972066 no 2107 0.375118538810483 3080 5722370 SGTC_2335 9018011 154.17 µM -0.318692931052757 0.379911969506158 no 2108 0.374979687788302 3058 6458208 SGTC_2808 7946468 45.46 µM -0.318715959310326 0.379903716922874 no 2109 0.374970955763694 3046 2970879 SGTC_2907 7721985 69.9 µM -0.320370827800866 0.379310808935853 no 2110 0.374343618562573 3034 3267881 SGTC_2821 7996764 71.43 µM -0.321655111621286 0.378850869880169 no 2111 0.373856993835265 3203 2987135 SGTC_482 fipronil 114 µM -0.322669911997479 0.378487561876179 no 2112 0.373472620508752 3012 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_688 0527-0193 473 µM -0.324372668841303 0.377878200426619 no 2113 0.372827954584741 2996 4007154 SGTC_1444 4112-3581 28 µM -0.325256518853321 0.377562018826344 no 2114 0.372493468072679 2990 2877249 SGTC_3000 9075062 71.4286 µM -0.326786994354003 0.377014712591689 no 2115 0.371914498434659 2997 17057871 SGTC_2828 7998861 71.43 µM -0.327040004292788 0.37692425864563 no 2116 0.371818814155 3098 2988188 SGTC_2010 4012422 159 µM -0.327853429043123 0.376633495785741 no 2117 0.37151124369866 3050 952393 SGTC_3181 9108277 49.47 µM -0.329224722853713 0.376143478247168 no 2118 0.370992918731572 2997 17097298 SGTC_363 0455-0021 3.06 µM -0.330597268818803 0.375653213128551 no 2119 0.370474354745005 2959 4597466 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.330793833101503 0.375583017966959 no 2120 0.370400109687649 3033 368090 SGTC_3300 9124615 50.48 µM -0.332579168910809 0.37494564471102 no 2121 0.369725984935425 3176 24824903 SGTC_347 4534-1311 26.2 µM -0.333335124241573 0.374675867889127 no 2122 0.369440664323234 2949 2862016 SGTC_1277 0873-0036 22 µM -0.333638693059361 0.374567550919924 no 2123 0.369326108409162 3074 5965735 SGTC_517 1365-0151 113 µM -0.33368424046815 0.374551299915744 no 2124 0.36930892146192 3157 768657 SGTC_984 1492-0255 2.91 µM -0.334835958643576 0.374140448867136 no 2125 0.368874416796296 3094 1585198 SGTC_3285 9112818 20.8695 µM -0.336516676499787 0.373541144950825 no 2126 0.368240639044499 2976 17017947 YPR165W RHO1 SGTC_1499 4480-0877 67.3 µM -0.338430745815803 0.372859005825028 no 2127 0.367519303897738 2999 2861909 SGTC_2182 6325192 200 µM -0.33850607094886 0.37283216946735 no 2128 0.367490926445735 3054 736248 SGTC_2046 4110841 106 µM -0.339490508260176 0.372481497209426 no 2129 0.367120123146496 3177 44119630 YMR134W ERG29 SGTC_1088 bifonazole 369 nM -0.339684963552834 0.372412241626461 no 2130 0.367046893244919 3079 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1034 k072-0165 12.7 µM -0.341236186536001 0.371859918823625 no 2131 0.366462891718374 3162 5835461 SGTC_3001 9076041 71.4286 µM -0.343464815031368 0.371066863140838 no 2132 0.365624403104376 2987 16004211 SGTC_48 0382-0018 55 µM -0.343552255335892 0.371035758713234 no 2133 0.365591518035008 3271 762596 SGTC_959 1222-0044 107 µM -0.345557986271792 0.370322508072917 no 2134 0.364837462489332 3153 6083612 SGTC_1619 st003326 88.7 µM -0.346751351740748 0.369898351019521 no 2135 0.36438906387238 3159 2849032 SGTC_3075 9116269 49.47 µM -0.347096243304579 0.36977579590046 no 2136 0.364259507841081 3215 17015205 YNL244C SUI1 SGTC_1882 5615643 20 µM -0.347270036947233 0.369714044397629 no 2137 0.364194229386744 3083 2253075 SGTC_172 1112-0046 2.638 µM -0.347667715907421 0.369572755706761 no 2138 0.364044872418899 3027 2802135 YIL048W NEO1 SGTC_500 h-89 112 µM -0.34837384107173 0.369321924637863 no 2139 0.363779722678173 3176 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1683 st010134 710 nM -0.348445427391276 0.369296498718308 no 2140 0.363752845680441 2993 3818134 SGTC_958 1222-0007 33 µM -0.351563724164287 0.368189503125849 no 2141 0.362582737207517 3183 7312461 SGTC_1560 lithocholic acid 53.1 µM -0.352603915073608 0.367820478036465 no 2142 0.362192701044221 3096 9903 A bile acid which acts as a detergent. SGTC_1390 3413-2614 145 µM -0.352693524236645 0.367788693391806 no 2143 0.362159107346298 3091 3421432 SGTC_2882 9058044 58.44 µM -0.354037561448899 0.36731206801671 no 2144 0.361655366971549 3108 18076804 SGTC_612 0302-0167 22.4 µM -0.35553739587577 0.366780434788468 no 2145 0.361093517310955 3094 235821 SGTC_928 2764-0428 58.7 µM -0.357140548875203 0.36621246156342 no 2146 0.360493294921623 3134 662578 SGTC_1363 1636-0063 10.4 µM -0.35715597947472 0.366206996153512 no 2147 0.360487519353978 3055 6072185 SGTC_1196 1588-0294 184 µM -0.357183009781713 0.366197422274151 no 2148 0.360477402172039 3086 6144269 SGTC_186 3455-3465 67.277 µM -0.357319586076544 0.366149049514619 no 2149 0.3604262844823 3008 755278 SGTC_2044 5102272 200 µM -0.358487167178344 0.36573560110376 no 2150 0.359989384866269 3132 592666 SGTC_140 0062-0056 502.533 µM -0.359253484810128 0.365464327529778 no 2151 0.359702734213457 2989 3758964 SGTC_321 4534-3890 65.3 µM -0.362461895037678 0.364329294294592 no 2152 0.358503446850969 3144 699746 SGTC_2891 9063876 19.48 µM -0.3647620390335 0.363516307614755 no 2153 0.357644521985217 3136 6472478 SGTC_3020 9089140 49.47 µM -0.364948520768238 0.363450422453383 no 2154 0.357574917077702 3141 17217859 SGTC_488 nitrendipine 139 µM -0.365073524343838 0.363406260170531 no 2155 0.357528261742627 3056 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1461 k072-0203 53.8 µM -0.365859087674667 0.363128771521796 no 2156 0.35723511312336 3106 5418714 SGTC_558 k064-0027 21.3 µM -0.366484097784381 0.362908047228675 no 2157 0.357001938306269 3135 5088526 SGTC_1371 2421-0008 32.7 µM -0.366968208042663 0.362737113453118 no 2158 0.356821366212431 3062 2827552 SGTC_72 0744-0168 198.391 µM -0.367523504914457 0.362541078180789 no 2159 0.356614281163974 2983 677577 SGTC_1901 st060216 58.6 µM -0.368491248192553 0.362199523972152 no 2160 0.35625348485357 3024 688792 SGTC_926 2268-1401 59.4 µM -0.368705770891285 0.362123825418266 no 2161 0.35617352340794 3088 2931578 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.369071063231056 0.361994937241093 no 2162 0.356037378462464 3072 4620898 SGTC_1529 apigenin 74 µM -0.369243881708268 0.361933966165403 no 2163 0.355972975178506 3290 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2986 9022445 71.43 µM -0.369275621190644 0.361922768725163 no 2164 0.355961147451854 3205 6459286 SGTC_2639 lactacystin 53 µM -0.371228174559665 0.361234150853979 no 2165 0.355233794892607 3208 3870 A proteasome inhibitor. SGTC_1265 0819-1001 68.8 µM -0.371540121177855 0.361124176479192 no 2166 0.355117639318543 3116 3106768 SGTC_1699 st031318 29.054 µM -0.373077400628291 0.360582388270604 no 2167 0.354545419041042 3166 5340658 SGTC_3313 9133968 57.047 µM -0.375168808653972 0.359845756130255 no 2168 0.353767462956511 3088 1494643 SGTC_2476 5806916 10.51 µM -0.376349086078989 0.35943027031938 no 2169 0.353328695825324 3039 2870194 SGTC_3101 9120531 49.47 µM -0.377111377056547 0.35916201397911 no 2170 0.35304541833301 3265 24824904 SGTC_539 4859-0462 2.54 µM -0.379085221850649 0.358467724971684 no 2171 0.352312290006037 3209 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_448 monastrol 171 µM -0.380022227229761 0.358138302021571 no 2172 0.351964457888125 3120 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_413 propylparaben 100 µM -0.380143857736769 0.35809554812543 no 2173 0.351919315678316 3061 7175 A pharmaceutical preservative. SGTC_1028 k015-0029 4.8 µM -0.380353946334344 0.358021704839926 no 2174 0.351841347857616 3055 4588309 SGTC_2763 lisinopril 49.32 µM -0.381608616454507 0.357580816019127 no 2175 0.351375846037426 3121 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1314 1222-0010 41.1 µM -0.381886544401162 0.357483178322285 no 2176 0.351272760639389 3131 3526027 SGTC_998 3996-0085 177 µM -0.382573209483022 0.357241988906471 no 2177 0.351018118731422 3117 715391 SGTC_588 3970-1144 52.9 µM -0.38451838891082 0.356559059290766 no 2178 0.350297134587768 3166 1888707 SGTC_104 0074-0074 590.992 µM -0.385469479033935 0.356225309905754 no 2179 0.349944807456282 3031 3943124 SGTC_2443 5493264 126.67 µM -0.386361609306405 0.35591235034013 no 2180 0.349614439120104 3217 5340055 SGTC_2268 7933382 153.85 µM -0.387357834783011 0.355562988870453 no 2181 0.34924565743729 3117 935025 YOR257W CDC31 SGTC_1812 st052057 4.327 µM -0.387792273770631 0.355410675541967 no 2182 0.349084881811578 3060 3645418 SGTC_2450 5739737 12.93 µM -0.388650361042612 0.355109899946998 no 2183 0.34876740354794 3180 2262825 SGTC_2203 7227154 166.4 µM -0.389156105606484 0.354932669304726 no 2184 0.348580335896722 3128 896304 SGTC_1230 0170-0365 3.77 µM -0.389378208293326 0.354854846645629 no 2185 0.348498194933621 3218 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2533 agelasine 13.65 µM -0.390911950103367 0.354317603634852 no 2186 0.347931160263491 3295 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1476 4112-3294 3.34 µM -0.391266570484576 0.354193427506644 no 2187 0.34780010305601 3220 704369 SGTC_859 0439-0102 54.6 µM -0.393315254415397 0.353476351150928 no 2188 0.347043326439177 3224 610143 SGTC_1946 st076057 65.1 µM -0.393658544416507 0.353356244227379 no 2189 0.346916575878384 3078 953009 SGTC_956 1185-0240 191 µM -0.394277085290956 0.353139872105756 no 2190 0.346688239608612 3097 1416193 SGTC_1964 st076914 61 µM -0.395592059946464 0.352680037909787 no 2191 0.346202997762365 3125 24208661 SGTC_2193 5925765 200 µM -0.397171550885422 0.35212798934114 no 2192 0.345620479815567 3185 877370 SGTC_409 arachidonic acid 100 µM -0.398084879223824 0.351808913604045 no 2193 0.3452838099642 3118 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_826 1683-5028 118 µM -0.39820434540855 0.351767185218443 no 2194 0.345239781547549 3179 722377 SGTC_1117 retinoic acid 1.10837 µM -0.401489148387078 0.350620536330632 no 2195 0.344030013006848 3257 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1495 4469-0029 237 µM -0.401720748023338 0.350539741434715 no 2196 0.343944776623878 3124 793680 SGTC_925 2064-1272 59.6 µM -0.402833330048725 0.350151704955843 no 2197 0.343535419983478 3122 6815817 SGTC_2711 st079103 59.1 µM -0.403733871251715 0.349837736692696 no 2198 0.343204214649803 3149 54693780 SGTC_598 3937-0236 20.2 µM -0.405110787919101 0.349357881518681 no 2199 0.342698038530915 3180 1379313 SGTC_1054 3429-0080 167 µM -0.406981073598831 0.348706472926653 no 2200 0.342010944493415 3272 1162877 SGTC_1714 st033236 13.627 µM -0.4071367675769 0.348652265778984 no 2201 0.341953770142621 3295 2916566 SGTC_2433 5607874 27.82 µM -0.407629464419181 0.348480746493935 no 2202 0.341772864602496 3107 2252428 SGTC_1872 amphotericin b 148 nM -0.408498967146556 0.348178127857796 no 2203 0.341453694336707 3215 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2049 5262831 67.185 µM -0.409202185561592 0.347933452897698 no 2204 0.341195645311707 3187 763417 SGTC_1090 efavirenz 20.7 µM -0.410586832158848 0.347451869697957 no 2205 0.340687760401216 3159 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2207 7258803 200 µM -0.411407876735378 0.347166424738415 no 2206 0.340386739580504 3207 3666799 SGTC_2149 5554786 194.827 µM -0.411643207301514 0.347084625517362 no 2207 0.340300478715491 3138 745063 YPR165W RHO1 SGTC_236 1509-0011 5.31 µM -0.411700977368865 0.347064546144266 no 2208 0.340279304265061 3277 3107280 SGTC_3266 9136860 49.47 µM -0.412472377866245 0.346796468557597 no 2209 0.339996611288053 3213 4871271 YPR165W RHO1 SGTC_345 1362-0200 395 µM -0.412866321084375 0.346659594732858 no 2210 0.339852278704012 3137 1419823 SGTC_1430 4049-0248 69.1 µM -0.414167285344112 0.346207722734644 no 2211 0.339375799374741 3228 22774488 SGTC_1850 st056238 17 µM -0.414312538975218 0.346157284458856 no 2212 0.339322616017793 3173 5393177 SGTC_3248 9135562 49.47 µM -0.414925060095709 0.345944620942707 no 2213 0.339098381938371 3174 17650701 SGTC_110 0850-0284 111.64 µM -0.414930938607361 0.345942580195372 no 2214 0.339096230186242 3027 3906265 SGTC_1150 3909-7983 10.9 µM -0.416410527971205 0.345429077655679 no 2215 0.338554812966037 3158 23965914 SGTC_1766 st045414 44.774 µM -0.418757858244937 0.344615002845646 no 2216 0.337696553118977 3155 253960 SGTC_1735 st034310 56.75 µM -0.419631562152614 0.344312178067209 no 2217 0.337377313851026 3301 871153 SGTC_2937 9044753 11.33 µM -0.421631495668524 0.343619379273516 no 2218 0.33664700676972 3108 6465530 YGL099W LSG1 SGTC_3230 9131665 49.47 µM -0.421747382714076 0.34357925080465 no 2219 0.336604707642775 3168 15943720 SGTC_710 3448-4187 58 µM -0.42404549639408 0.342783842392789 no 2220 0.335766316697844 3188 3946412 SGTC_2362 9071156 126 µM -0.425941496935796 0.34212813489461 no 2221 0.335075238090241 3283 653133 SGTC_2072 5231554 129 µM -0.426528841839837 0.341925105610413 no 2222 0.334861268166203 3294 789545 SGTC_699 0375-0592 111 µM -0.426886538040808 0.341801482074487 no 2223 0.334730985589084 3302 762578 SGTC_2740 felodipine 17.08 µM -0.426988485569109 0.341766251051575 no 2224 0.33469385719933 3216 3333 L-type calcium channel blocker SGTC_2252 omeprazole 400 µM -0.427829792324309 0.341475564933363 no 2225 0.334387522436342 3117 4594 A proton pump inhibitor. SGTC_2497 7-hydroxyflavone 100 µM -0.429782177501724 0.340801344357129 no 2226 0.33367704931029 3287 5281894 SGTC_514 4466-0038 2.65 nM -0.430281874222906 0.340628864814567 no 2227 0.333495305321204 3157 5722064 SGTC_2642 cholecalciferol 100 µM -0.431482975173375 0.340214419017578 no 2228 0.333058614492118 3243 9821465 A vitamin D precursor, similar to steriods. SGTC_1568 digitonin 820 nM -0.433629736356996 0.339474149396962 no 2229 0.332278668739499 3323 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1940 st075990 51.1 µM -0.434177266906472 0.339285442888174 no 2230 0.332079859933192 3406 1084979 SGTC_2675 theaflavin digallate 100 µM -0.43457899589525 0.339147012544109 no 2231 0.331934021850327 3236 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2326 6164455 177.58 µM -0.435585862095375 0.338800155583547 no 2232 0.331568615111301 3211 2888790 SGTC_1313 1220-0047 237 µM -0.437528719352594 0.338131243988673 no 2233 0.33086397641285 3227 3528706 SGTC_2420 aureobasidin a 50 nM -0.43812488965996 0.337926089190334 no 2234 0.330647876323644 3383 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2788 5282734 71.43 µM -0.440285165857482 0.337183096094801 no 2235 0.329865291636158 3322 743706 SGTC_892 0929-0076 29 µM -0.443299537031647 0.336147411393343 no 2236 0.328774545311092 3212 5751038 SGTC_3209 9113616 49.47 µM -0.445157671298817 0.335509607744973 no 2237 0.328102906974493 3380 16649353 SGTC_1665 st014639 11.4 µM -0.445341708893871 0.335446462686272 no 2238 0.328036415224475 3273 981133 YIL048W NEO1 SGTC_2156 5649887 115 µM -0.445806715542666 0.335286935170352 no 2239 0.327868435216152 3279 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1263 0774-1208 64.8 µM -0.445997577203804 0.335221465805399 no 2240 0.327799498013625 3356 906585 SGTC_1798 st045719 60.953 µM -0.449322067356192 0.334081903573408 no 2241 0.32659967055131 3272 3980186 SGTC_1251 0490-5699 265 µM -0.449409505683842 0.334051952211843 no 2242 0.326568137684915 3362 3883818 SGTC_2978 9011784 42.97 µM -0.451819758708364 0.333226754291203 no 2243 0.325699417122845 3262 2994934 SGTC_2438 5259590 200 µM -0.452580757587293 0.332966378595212 no 2244 0.325425328691742 3268 1201127 SGTC_2491 paeonol 100 µM -0.452778929936281 0.332898587152671 no 2245 0.325353968580545 3217 11092 Increases levels of cortical cytochrome oxidase. SGTC_1859 st055998 20 µM -0.454038169847769 0.332467949956177 no 2246 0.324900677114801 3360 676301 SGTC_55 0767-0285 6.563 µM -0.454916682770156 0.332167645332674 no 2247 0.324584590209393 3300 3116166 SGTC_47 0149-0135 24.25 µM -0.455361218273981 0.332015729511402 no 2248 0.324424695480622 3189 5239155 SGTC_708 3448-5400 146 µM -0.458096893393293 0.331081446845869 no 2249 0.323441415370853 3302 3462195 SGTC_1900 st060200 72.8 µM -0.458871155959141 0.33081721266553 no 2250 0.323163346534714 3191 688945 SGTC_3290 9121031 71.43 µM -0.460544684222741 0.330246372289503 no 2251 0.322562652868202 3243 17014854 SGTC_2960 9079389 5.97 µM -0.461811734849342 0.329814443972128 no 2252 0.322108167426779 3343 16457355 SGTC_2687 chenodiol 100 µM -0.462295767880932 0.329649500489663 no 2253 0.321934617073828 3310 5702181 A cholesterol synthesis inhibitor. SGTC_1612 st002233 45.4 µM -0.4625089448622 0.32957686687611 no 2254 0.321858194645745 3310 1035021 SGTC_2250 alverine citrate 130 µM -0.464186989006937 0.329005348691536 no 2255 0.321256891084829 3261 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.466138318049288 0.328341255935623 no 2256 0.320558248578924 3358 688798 SGTC_1807 st050092 58.9 µM -0.467534201302927 0.327866529582634 no 2257 0.320058864245151 3228 5008496 SGTC_1294 1000-1494 117 µM -0.46972219052794 0.327122975295365 no 2258 0.319276755839512 3260 712797 YDL207W GLE1 SGTC_802 4112-3352 742 µM -0.470241367797837 0.32694664147041 no 2259 0.319091290983801 3358 704594 SGTC_2004 4023728 41.89 µM -0.471590813901167 0.326488495193246 no 2260 0.318609442402102 3368 360084 YDR527W RBA50 SGTC_682 0kpi-0099 17 µM -0.471670133479294 0.326461573782255 no 2261 0.318581129183054 3321 1714895 YML126C ERG13 SGTC_177 1327-0068 8.361 µM -0.472714408228496 0.32610722670445 no 2262 0.3182084728765 3329 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_103 0844-0104 51.839 µM -0.474439426348478 0.325522231207022 no 2263 0.317593291801067 3344 5375804 SGTC_428 3448-4153 16.5 µM -0.475880317981304 0.325033919037224 no 2264 0.31707982245158 3150 3834874 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.476419645061508 0.324851220552979 no 2265 0.316887720876373 3262 6708630 An antioxidant. SGTC_2831 7999036 19.48 µM -0.476510495315058 0.324820448931757 no 2266 0.316855366005723 3393 2988270 SGTC_1052 3253-3998 198 µM -0.477301420526981 0.32455260750808 no 2267 0.316573749787756 3227 5450317 SGTC_1614 st002383 48.6 µM -0.477874798694425 0.324358493617349 no 2268 0.316369659653243 3328 1947235 SGTC_8 0354-0001 70 µM -0.478191730487356 0.324251218651234 no 2269 0.316256873886583 3284 4993152 SGTC_2483 5729050 27.16 µM -0.47905215546725 0.323960055873873 no 2270 0.315950762700024 3400 2865180 SGTC_2474 5321570 43.32 µM -0.479162354995218 0.323922772772994 no 2271 0.315911566406135 3309 2841384 SGTC_2742 clothiapine 36.27 µM -0.4792135702543 0.323905446043435 no 2272 0.315893350622853 3291 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1726 st035556 14.5795 µM -0.479688295363349 0.323744859072633 no 2273 0.315724525942888 3406 5919439 SGTC_123 0083-0120 66.675 µM -0.48022658020236 0.323562811215479 no 2274 0.315533144265108 3257 16001701 SGTC_2472 5377652 49.4 µM -0.481162978195432 0.323246222168419 no 2275 0.315200335416917 3277 1610903 SGTC_2504 purpurogallin 52.29 µM -0.481348382131494 0.323183553675496 no 2276 0.315134458056771 3211 5281571 An antioxidant. SGTC_3226 9131256 49.47 µM -0.481730459526159 0.323054423298216 no 2277 0.31499871761482 3285 17178073 SGTC_2630 antimycin a 100 µM -0.481807898595341 0.323028253879146 no 2278 0.31497120892031 3224 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1962 st076595 64.5 µM -0.48271969906903 0.322720189940525 no 2279 0.314647387095317 3257 279619 SGTC_942 3253-1115 227 µM -0.483447404212393 0.322474412323656 no 2280 0.314389048131919 3401 46497897 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.483781947503742 0.322361448550695 no 2281 0.314270314074791 3247 4174840 SGTC_2783 7738165 71.43 µM -0.484580410327401 0.322091901397514 no 2282 0.313987006215526 3272 17201110 SGTC_3157 9099274 49.47 µM -0.486268204297406 0.321522439539582 no 2283 0.313388509756223 3379 17217662 SGTC_3069 9117009 49.47 µM -0.486631763491999 0.321399829455188 no 2284 0.313259654877613 3247 41904981 SGTC_2415 st077333 57.7 µM -0.486663139473071 0.321389248839433 no 2285 0.313248535478376 3447 2766255 SGTC_1742 st038235 28.8875 µM -0.48705922119099 0.321255694534227 no 2286 0.313108181856894 3320 564103 YBR002C RER2 SGTC_2469 5655019 90.81 µM -0.48766674700769 0.321050888569776 no 2287 0.312892954533672 3377 2788239 SGTC_2264 7948757 110.76 µM -0.488525241664241 0.320761570091616 no 2288 0.312588925546406 3180 2971411 SGTC_212 3807-4682 38.772 µM -0.488922795544463 0.320627628615179 no 2289 0.312448178208777 3337 3125501 YBL034C STU1 SGTC_3155 9099265 49.47 µM -0.49157591274387 0.319734354873237 no 2290 0.311509587448914 3340 25236499 SGTC_1530 rhein 70.4 µM -0.491860908311956 0.319638462217606 no 2291 0.311408837509833 3333 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2973 9094665 17.96 µM -0.492192587705725 0.319526877003693 no 2292 0.311291601963927 3412 25237061 YIL048W NEO1 SGTC_2191 5911152 200 µM -0.492639972905507 0.319376391356182 no 2293 0.311133499309768 3303 2875902 SGTC_2103 5378138 10 µM -0.493904271835916 0.318951283711009 no 2294 0.310686893760299 3399 244142 SGTC_2327 6189656 200 µM -0.495868390233065 0.318291341185329 no 2295 0.309993634615313 3345 5349088 SGTC_2651 TUB2.036 5 µM -0.496637939756987 0.318032930049557 no 2296 0.309722196777156 3440 15992207 YFL037W TUB2 SGTC_19 0279-0214 38.434 µM -0.498009593477204 0.317572554807826 no 2297 0.309238640197386 3353 3566274 YBR002C RER2 SGTC_1637 st007924 17.4 µM -0.499261771318288 0.317152526040437 no 2298 0.308797491397609 3295 683336 SGTC_2381 9035592 200 µM -0.500113126690562 0.31686708301462 no 2299 0.308497711867174 3320 4749657 SGTC_3060 1327-0027 12.5 µM -0.501613992250504 0.316364137228403 no 2300 0.3079695374818 3300 16000455 YPR107C YTH1 SGTC_196 k015-0023 18.111 µM -0.501708042473316 0.316332631932863 no 2301 0.307936453193261 3281 5211998 SGTC_3213 9129884 49.47 µM -0.502515259240913 0.316062282281121 no 2302 0.307652560696805 3334 17190742 SGTC_1418 3966-3099 2.4 µM -0.502663800235346 0.31601254426226 no 2303 0.307600332405592 3367 740335 SGTC_1015 4130-4525 82 µM -0.503664960124928 0.315677399061064 no 2304 0.307248417734241 3269 1363237 SGTC_1698 5-fluorocytosine 1.055 µM -0.503993430224437 0.315567474419222 no 2305 0.307132996845769 3389 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1672 st016598 6.51 µM -0.504107742715455 0.315529222832161 no 2306 0.307092833137154 3298 4665860 YNL267W PIK1 SGTC_2062 5245942 200 µM -0.507095212880725 0.314530248466512 no 2307 0.306044006874843 3403 1376160 SGTC_2124 5246320 200 µM -0.507871048484986 0.314271039861375 no 2308 0.305771889763029 3360 579342 SGTC_180 1486-1293 102.781 µM -0.509075566488181 0.313868788861785 no 2309 0.305349628749496 3459 4140536 SGTC_175 3793-3120 23.7 µM -0.509227116248502 0.313818194191308 no 2310 0.305296519136697 3275 5322297 SGTC_3217 9129673 49.47 µM -0.509605586927556 0.313691857586253 no 2311 0.305163904486413 3427 17248312 SGTC_642 0335-0876 158 µM -0.510398164955246 0.313427359352876 no 2312 0.304886271111162 3335 6812350 SGTC_761 k216-0224 480 µM -0.510685917151491 0.313331354745284 no 2313 0.304785501729468 3459 1340404 SGTC_3182 9108849 49.47 µM -0.512136398716245 0.312847613965847 no 2314 0.304277775893086 3398 17133045 SGTC_1279 0874-0590 65.2 µM -0.512197886136386 0.312827114802425 no 2315 0.304256261191867 3337 3523074 SGTC_2402 5553605 200 µM -0.513103411211504 0.312525290731194 no 2316 0.303939492741412 3453 6758546 SGTC_1594 piperine 70.1 µM -0.51436942383251 0.312103521913571 no 2317 0.30349686618084 3320 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3272 9137413 49.47 µM -0.516099439816943 0.311527569680827 no 2318 0.302892479591159 3346 17614870 SGTC_1309 pyrazolanthrone 13.4 µM -0.516384873248774 0.311432588211656 no 2319 0.302792814316234 3398 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1482 3346-2049 8.48 µM -0.517699849239752 0.310995176008528 no 2320 0.302333851728295 3379 3826804 SGTC_82 0054-0107 293.755 µM -0.517775367348797 0.310970063843423 no 2321 0.30230750332088 3351 3104697 SGTC_791 1348-1292 225 µM -0.518124198889666 0.310854077723164 no 2322 0.302185808725588 3392 5437054 SGTC_565 1418-0001 44.5 µM -0.518769041435467 0.310639717734802 no 2323 0.3019609046058 3452 2862145 SGTC_237 nikkomycin 200 µM -0.519078283013247 0.310536941761442 no 2324 0.301853075959712 3442 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1248 0469-0687 58.6 µM -0.519567534167456 0.310374370082763 no 2325 0.301682515594329 3391 4017482 SGTC_1655 st012546 55.1 µM -0.519882616435045 0.310269692024498 no 2326 0.301572696088885 3369 720985 YLR208W SEC13 SGTC_825 1988-2224 89.6 µM -0.519925128148018 0.310255569767178 no 2327 0.301557880334711 3300 1180859 SGTC_1397 3532-0190 20.1 µM -0.520852855326789 0.30994745142344 no 2328 0.301234639782264 3275 5322280 SGTC_2053 5265679 138 µM -0.520863241391396 0.30994400274072 no 2329 0.301231021932435 3316 764595 SGTC_1442 4112-3290 3 µM -0.52112196049263 0.309858100710389 no 2330 0.301140906832486 3337 704353 SGTC_38 0929-0051 58.268 µM -0.521502627426158 0.309731727438435 no 2331 0.301008337866096 3365 1379719 SGTC_2073 5212005 126 µM -0.522359685377085 0.309447284868077 no 2332 0.300709959932801 3320 691789 SGTC_519 k048-0011 62.8 µM -0.523513135651285 0.309064655024804 no 2333 0.300308606206137 3369 6836379 SGTC_1357 1503-1303 39.5 µM -0.524020288560686 0.30889648455089 no 2334 0.30013221430524 3361 292895 SGTC_775 4577-0580 57.3 µM -0.52432983904104 0.308793858167568 no 2335 0.300024573167368 3493 2006902 SGTC_2127 5253358 187.912 µM -0.524439607792716 0.308757469723894 no 2336 0.299986407067149 3280 20612 SGTC_2090 5301565 104.445 µM -0.525224727597077 0.308497256531273 no 2337 0.299713488525282 3357 2056344 SGTC_2792 7535235 81.82 µM -0.528716714481037 0.307341069540546 no 2338 0.298500990262179 3326 1281891 SGTC_3314 9135860 59.4275 µM -0.529859031696297 0.306963266006483 no 2339 0.298104836380971 3431 25252478 SGTC_3153 9100258 49.47 µM -0.529923208342417 0.306942046660934 no 2340 0.298082587125545 3305 25236848 SGTC_2948 9070189 9.45 µM -0.530625734696515 0.306709805874463 no 2341 0.297839079353594 3386 6473636 YDL196W YDL196W SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.531034381052947 0.30657475146008 no 2342 0.29769747721072 3329 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_455 paf C-16 10 µM -0.532473316933585 0.306099403587188 no 2343 0.297199108854576 3366 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_661 1304-0007 33.6 µM -0.533291221128988 0.305829356939791 no 2344 0.296916001859767 3358 3117130 SGTC_2285 7945142 200 µM -0.533902532924319 0.305627589615805 no 2345 0.296704484774969 3404 2970608 SGTC_2473 5854593 8.94 µM -0.534577717310146 0.305404809313181 no 2346 0.296470947659944 3306 2872951 SGTC_3302 9125395 16.351 µM -0.535255492367516 0.305181246664373 no 2347 0.296236599229897 3320 17599668 SGTC_3010 9080089 71.4286 µM -0.536208058074999 0.304867167751249 no 2348 0.295907382508614 3416 17027233 SGTC_2374 9071832 200 µM -0.53622504249482 0.304861568970632 no 2349 0.29590151403942 3424 17381698 SGTC_3073 9114972 49.47 µM -0.539281193336593 0.303854877662883 no 2350 0.294846421781303 3392 41905075 SGTC_465 cgp-37157 41 µM -0.540601437374285 0.303420450461846 no 2351 0.294391163468247 3347 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_275 trichlorophene 5.69 µM -0.540603979770817 0.303419614152293 no 2352 0.294390287089591 3429 62616 SGTC_744 1594-0068 283 µM -0.540618780734995 0.303414745464189 no 2353 0.294385185136321 3378 668392 SGTC_1045 1348-1485 165 µM -0.541219665976291 0.303217117360919 no 2354 0.294178092000601 3401 6810614 SGTC_2774 tamoxifen 10.92 µM -0.541887708674248 0.302997469101476 no 2355 0.293947932316639 3453 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1342 1486-1464 234 µM -0.543350438962573 0.302516781347621 no 2356 0.293444271175434 3413 3253938 SGTC_2188 6126565 140.678 µM -0.543594104112267 0.302436740446865 no 2357 0.293360408943571 3426 874518 SGTC_2667 digitoxin 100 µM -0.544368585336517 0.302182396306656 no 2358 0.293093929524295 3397 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_618 k072-0232 33.2 µM -0.545325532237553 0.301868262049699 no 2359 0.292764823425889 3384 5872756 YGL099W LSG1 SGTC_1002 4049-0206 172 µM -0.545945227258944 0.301664914831475 no 2360 0.292551794080547 3391 4662749 SGTC_22 0964-0034 14.468 µM -0.546233952977371 0.30157019318541 no 2361 0.292452564941613 3400 138402 SGTC_1873 rapamycin 2 nM -0.546263054974658 0.301560646496 no 2362 0.292442564046905 3407 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_112 phenothiazine 287.218 µM -0.546346812001178 0.3015331713977 no 2363 0.292413781851169 3454 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3018 9082602 49.47 µM -0.546828044567072 0.301375332895813 no 2364 0.292248437014894 3458 17332089 SGTC_2077 5212015 200 µM -0.547142351915996 0.301272263944468 no 2365 0.292140468853066 3371 780900 SGTC_2741 miltefosine 3.04 µM -0.547166359559891 0.30126439191232 no 2366 0.292132222716485 3333 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.54817225279134 0.300934645925138 no 2367 0.291786816274586 3421 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1190 1486-1332 13 µM -0.549296383993971 0.300566332554707 no 2368 0.291401034250366 3405 4150046 SGTC_604 1000-0114 314 µM -0.551345712914829 0.29989540923696 no 2369 0.290698353699934 3475 1572745 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.551624487848129 0.299804194396306 no 2370 0.290602827713268 3527 6710655 SGTC_1061 3448-9325 110 µM -0.552446368836399 0.299535349013658 no 2371 0.290321284628078 3452 723482 SGTC_2194 5927483 104.545 µM -0.552735061190066 0.29944094083388 no 2372 0.290222420662895 3435 760979 SGTC_2346 9031566 143.75 µM -0.553509096605374 0.29918788235872 no 2373 0.289957426695511 3361 4771086 SGTC_1983 st071813 46.9 µM -0.55469907369125 0.298799027835695 no 2374 0.289550254945074 3413 11838595 SGTC_996 3970-0799 1.8 µM -0.55495097336875 0.298716742833974 no 2375 0.289464097449551 3472 6615648 YGL040C HEM2 SGTC_941 3237-0776 460 µM -0.555375926419338 0.298577951945452 no 2376 0.289318777635588 3482 760008 SGTC_2012 4023501 200 µM -0.557115753492632 0.298010025519598 no 2377 0.288724172429247 3367 3477460 SGTC_3225 9130819 49.47 µM -0.558161282100599 0.29766897382009 no 2378 0.288367128452416 3478 4547121 SGTC_532 1548-0774 215 µM -0.558347280140798 0.297608319877258 no 2379 0.288303632657513 3572 5932993 SGTC_1343 1487-0095 224 µM -0.562866138462836 0.296136457292548 no 2380 0.28676301976343 3480 4560101 YGL055W OLE1 SGTC_1995 st072814 61.1 µM -0.564497713679581 0.295605849704412 no 2381 0.286207727846446 3366 5769371 SGTC_557 1315-0110 16.2 µM -0.565926592890988 0.295141520557798 no 2382 0.285721841535961 3451 6833801 SGTC_160 3453-0671 289.699 µM -0.56820154316293 0.294402945667694 no 2383 0.284949061874527 3402 5322268 SGTC_1436 4092-1007 8.32 µM -0.570501409466437 0.293657150186439 no 2384 0.284168833209218 3430 2881121 SGTC_1458 k015-0034 6.33 µM -0.570741411501651 0.293579373284204 no 2385 0.284087471523442 3428 3598957 SGTC_2645 abamectin 100 µM -0.571176050479319 0.29343854512264 no 2386 0.283940155473956 3462 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1421 4029-0249 71.4 µM -0.571956641964926 0.293185702865144 no 2387 0.283675674490419 3529 2894095 SGTC_2589 lobaric acid 100 µM -0.572246413130351 0.293091868480223 no 2388 0.283577523902346 3390 73157 A novel microtubule depolymerizer. SGTC_525 k781-2675 26.7 µM -0.573197186132329 0.292784084788376 no 2389 0.283255594700405 3508 3651118 YDL195W SEC31 SGTC_1738 st035555 74 µM -0.576830959301441 0.291609146924346 no 2390 0.282026826682993 3473 5331140 SGTC_801 0866-0028 10.1 µM -0.580603298667973 0.290391736006139 no 2391 0.280753924285486 3498 6849771 SGTC_2026 5148700 152 µM -0.580709139407678 0.290357613384031 no 2392 0.280718250498792 3430 79838 SGTC_2125 5246583 200 µM -0.582626985830889 0.289739633020993 no 2393 0.280072217438901 3555 835267 SGTC_2876 9059903 25.97 µM -0.582879963113422 0.289658163210022 no 2394 0.27998705501084 3487 6916095 SGTC_2839 9003951 25.97 µM -0.58378473478506 0.289366874972798 no 2395 0.279682574906887 3492 2990634 SGTC_1171 0368-0077 21.4 µM -0.58395394327416 0.289312414141711 no 2396 0.279625649521535 3444 3239779 SGTC_1539 benzyladenosine 56 µM -0.584739264194771 0.289059716673107 no 2397 0.279361524271252 3429 92208 A nucleotide analog. SGTC_89 0302-0250 142.109 µM -0.586186246312085 0.288594384529106 no 2398 0.278875181600809 3551 4203518 YLR208W SEC13 SGTC_2382 9035899 200 µM -0.586433976911029 0.28851475272561 no 2399 0.278791958617384 3493 6462679 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.589110572885705 0.28765503489113 no 2400 0.277893550664812 3512 66535 A nucleotide analog. SGTC_1743 st037606 46.3785 µM -0.589777606968748 0.287440973347109 no 2401 0.277669878723477 3489 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1301 naphtanilide LB 4.81 µM -0.59000257821601 0.28736879359134 no 2402 0.277594460502085 3552 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_69 0096-0274 206.684 µM -0.590014468430515 0.287364978974509 no 2403 0.277590474765281 3647 6741392 SGTC_2586 curcumin 80 µM -0.590697441996079 0.287145907713885 no 2404 0.277361581104431 3483 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_152 4469-0003 551.229 µM -0.591173957272348 0.286993107055399 no 2405 0.277201935123915 3516 697280 SGTC_1014 4130-3005 69.3 µM -0.591504147490651 0.286887249975218 no 2406 0.277091338514327 3466 743608 SGTC_2239 6685329 187.64 µM -0.595253759149329 0.285686446015613 no 2407 0.275836930106754 3517 805680 SGTC_2385 9074692 200 µM -0.595383791897024 0.285644846282997 no 2408 0.275793478598298 3462 17046906 SGTC_1042 0350-0096 82 µM -0.596611032659637 0.285252372707475 no 2409 0.275383551795245 3492 3122515 SGTC_2752 diclazuril 33.15 µM -0.596727927989267 0.285215002798575 no 2410 0.275344521695066 3511 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1096 rimcazole 32.2 µM -0.597379541195173 0.285006733332878 no 2411 0.275127004910531 3444 18528119 A dopamine reuptake inhibitor. SGTC_1332 1480-0653 17.5 µM -0.59863557798917 0.284605481955426 no 2412 0.274707962746466 3495 5749438 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.598722144602537 0.28457783747126 no 2413 0.274679093771398 3513 140250 A respiratory chain inhibitor. SGTC_2179 6298986 200 µM -0.598739671091222 0.28457224065734 no 2414 0.274673249070084 3503 738374 SGTC_2594 a-mangostin 100 µM -0.598847470562391 0.284537817714366 no 2415 0.27463730164887 3533 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2255 7941087 197.44 µM -0.600354552657375 0.284056778816032 no 2416 0.274134984649858 3565 935561 SGTC_2187 6125751 200 µM -0.600773450848103 0.283923141673579 no 2417 0.273995444717904 3495 874498 SGTC_2289 7946404 165.07 µM -0.601694080935336 0.283629547506415 no 2418 0.273688895373166 3519 1246120 YPR165W RHO1 SGTC_3016 9080866 49.47 µM -0.601762953835767 0.283607589395402 no 2419 0.273665969052018 3498 17066299 SGTC_1849 st056239 19.2 µM -0.601861261726946 0.283576248209004 no 2420 0.273633246095676 3416 5393181 SGTC_1426 4048-4480 71.7 µM -0.601939622978911 0.28355126732778 no 2421 0.273607164003236 3533 14224343 SGTC_1206 3978-0017 132 µM -0.602876208901592 0.283252773582906 no 2422 0.273295522013142 3592 3873677 SGTC_697 0508-1955 564 µM -0.60381032816067 0.282955216177332 no 2423 0.272984876010008 3530 6243113 SGTC_886 0866-0150 153 µM -0.604369226738972 0.282777254584274 no 2424 0.272799095253234 3581 271463 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.605847251926215 0.282306888744524 no 2425 0.272308094549408 3443 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3165 9101544 49.47 µM -0.607357377336963 0.281826696492123 no 2426 0.271806884034375 3528 5002184 SGTC_1163 k060-0048 49.9 µM -0.607429725935743 0.281803700845598 no 2427 0.271782883068148 3535 6809982 SGTC_2393 9031399 185.94 µM -0.607986396710282 0.281626796029498 no 2428 0.271598248066735 3577 1526623 YDL150W RPC53 SGTC_2890 9046729 58.44 µM -0.608664683350433 0.281411315225341 no 2429 0.271373360304086 3418 903329 SGTC_1978 st071761 42 µM -0.613227892652605 0.279963728516186 no 2430 0.26986283207548 3462 5147680 SGTC_3080 9117754 49.47 µM -0.613945364789327 0.279736453745302 no 2431 0.269625715644374 3610 9550191 SGTC_116 0155-0182 31.788 µM -0.615510906305312 0.279240845726562 no 2432 0.269108684495133 3523 771486 SGTC_1712 st032288 53.4 µM -0.618587745657062 0.278268047075668 no 2433 0.26809398838094 3564 2883011 SGTC_1512 0259-0544 12.2 µM -0.619907696409483 0.277851227698262 no 2434 0.267659279199912 3545 18476 SGTC_765 1319-0117 244 µM -0.620488434596916 0.277667936450809 no 2435 0.267468132982918 3547 3487746 YGL099W LSG1 SGTC_410 α-linolenic acid 100 µM -0.620571220650411 0.277641812518214 no 2436 0.267440890096333 3581 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2778 tioconazole 65.09 nM -0.622140796400027 0.27714674515703 no 2437 0.26692464564419 3526 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.622519357902096 0.277027405954132 no 2438 0.266800209504598 3571 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1941 st076221 61.8 µM -0.623180833037469 0.276818940348363 no 2439 0.266582847816921 3543 2828568 SGTC_3205 9113483 49.47 µM -0.624021446285881 0.276554129818467 no 2440 0.266306750350878 3545 17018033 SGTC_2200 6600604 21.907 µM -0.627582800040902 0.275433609354383 no 2441 0.26513863955726 3526 2904777 SGTC_1885 st057546 99.9 µM -0.631707662080995 0.274138588384115 no 2442 0.263788960194976 3613 702008 SGTC_2584 androsterone 48.74 µM -0.631762375472709 0.274121431076355 no 2443 0.263771081220712 3627 2754130 A steroid. SGTC_756 0508-1999 28.3 µM -0.633025907005851 0.273725353985116 no 2444 0.263358362566796 3478 6753853 SGTC_2284 7945075 39.21 µM -0.633129938331858 0.273692756078634 no 2445 0.263324396577681 3588 1245402 SGTC_2896 9052656 71.43 µM -0.633155911353289 0.27368461780924 no 2446 0.263315916794788 3545 6469436 SGTC_3343 9148379 18.9835 µM -0.633683639808668 0.273519287687081 no 2447 0.263143651962346 3607 1955036 SGTC_3061 glucosamine 200 µM -0.634297607307742 0.273327002281481 no 2448 0.262943308862565 3526 91431 and experimental redox chemotherapeutic SGTC_3050 9093513 49.47 µM -0.634421786772406 0.273288119278243 no 2449 0.262902797472581 3586 25236664 SGTC_394 menadione 8.33 µM -0.635751111616616 0.272872053569512 no 2450 0.262469328386938 3551 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2331 7980721 200 µM -0.635776714088889 0.2728640433301 no 2451 0.262460983470778 3545 2981221 SGTC_1799 st045822 46.1415 µM -0.635996621833098 0.27279524564982 no 2452 0.262389311936863 3570 3674992 SGTC_1866 st057638 64 µM -0.63604128717704 0.27278127324135 no 2453 0.26237475599466 3541 688802 SGTC_374 0880-0231 82.3 µM -0.636865749626406 0.272523425068149 no 2454 0.26210614707088 3562 6833587 SGTC_2515 chrysin 20.77 µM -0.638486979161332 0.272016743574946 no 2455 0.261578363687125 3548 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1398 3558-0053 112 µM -0.638667671190904 0.271960301077299 no 2456 0.261519574082106 3499 4532369 SGTC_2628 lathosterol 100 µM -0.639104868322737 0.27182375856925 no 2457 0.26137735654665 3630 6710616 SGTC_1671 st016596 74.5 µM -0.639394637738582 0.271733278508237 no 2458 0.261283118232553 3608 2829167 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.641313204458112 0.271134587420975 no 2459 0.260659605933851 3593 688669 SGTC_1017 4239-0030 168 µM -0.644375531838968 0.27018034926632 no 2460 0.259665973568447 3535 1149593 SGTC_2611 pyromycin 23.93 µM -0.645719909883178 0.26976196481293 no 2461 0.259230382055989 3564 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_584 0986-0246 15.4 µM -0.646777009737065 0.269433212340111 no 2462 0.258888136885047 3669 53315 YDR232W HEM1 SGTC_1886 st057356 49.9 µM -0.646799457518032 0.269426233377067 no 2463 0.258880871758445 3544 24207747 SGTC_3292 9120825 59.784 µM -0.648033515595437 0.269042707066336 no 2464 0.258481636587506 3616 24824900 SGTC_1827 berberine 7.24 µM -0.648989733784946 0.268745717659921 no 2465 0.258172505969444 3513 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3262 9137218 49.47 µM -0.649856264728553 0.268476726307419 no 2466 0.257892535494139 3470 17650664 SGTC_2164 5685496 200 µM -0.65020643283655 0.268368064400272 no 2467 0.257779443178881 3595 759046 SGTC_1311 1190-0148 100 µM -0.65021567308829 0.268365197324552 no 2468 0.257776459242416 3638 1961333 SGTC_593 1203-0218 61.7 µM -0.650672943336668 0.268223334243496 no 2469 0.257628816252115 3624 3666956 SGTC_1733 st037357 54.9 µM -0.651173644621845 0.26806804044932 no 2470 0.257467200667716 3567 1272339 YGL099W LSG1 SGTC_3058 9093861 49.47 µM -0.651814331701031 0.267869395731919 no 2471 0.257260477527661 3630 17217477 SGTC_839 0122-0028 230 µM -0.652568841650646 0.267635555399804 no 2472 0.257017139147548 3602 759448 SGTC_1350 1495-0454 146 µM -0.654569538455063 0.267015991097887 no 2473 0.256372470906675 3626 1069057 SGTC_273 hydroxyurea 18.1 mM -0.654739221151412 0.266963478073863 no 2474 0.256317834224683 3647 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2424 5537928 59.2 µM -0.656184384961144 0.266516443491406 no 2475 0.255852747316805 3635 5382802 SGTC_1027 k015-0025 8.67 µM -0.656200797192984 0.266511368847414 no 2476 0.255847468014186 3596 3598955 SGTC_2486 5283202 22.39 µM -0.656206408149459 0.266509633957068 no 2477 0.255845663157695 3567 1377751 SGTC_1369 1866-0067 208 µM -0.656969542683365 0.266273728357209 no 2478 0.255600250304776 3629 3531355 SGTC_1693 xanthone 101.9 µM -0.657838888165258 0.266005118909542 no 2479 0.255320831455896 3619 7020 An insecticide. SGTC_486 niguldipine 82 µM -0.658705270489153 0.265737561640849 no 2480 0.255042523939183 3608 1236 A calcium channel blocker. SGTC_233 rapamycin 362 pM -0.659996694732381 0.265338995807036 no 2481 0.254627975213234 3625 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_653 0203-0016 55.2 µM -0.660052332112271 0.26532183153959 no 2482 0.25461012348072 3607 295302 SGTC_869 0564-0080 44.1 µM -0.660572181378321 0.265161484011821 no 2483 0.254443357049363 3579 6843321 SGTC_3232 9132874 49.47 µM -0.660821964628855 0.265084455865801 no 2484 0.254363247529388 3583 3784940 SGTC_2456 5770359 74.46 µM -0.663050845394679 0.264397617332688 no 2485 0.253648995210234 3623 3118787 SGTC_3111 9122088 49.47 µM -0.663084527188355 0.264387245105086 no 2486 0.253638209851594 3538 16876704 SGTC_805 3852-0218 479 µM -0.663678064515248 0.264204500698634 no 2487 0.253448190827943 3587 6615355 SGTC_793 0488-0545 106 µM -0.664668328971931 0.263899751111313 no 2488 0.253131327524408 3597 292548 SGTC_3356 9151811 4.48 µM -0.664697484429165 0.263890781362242 no 2489 0.253122001564579 3596 1859254 YPR165W RHO1 SGTC_2743 auranofin 4.32 µM -0.664986931701032 0.263801740619106 no 2490 0.253029425833003 3574 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1719 st032227 49.2 µM -0.665765635196038 0.263562269303177 no 2491 0.252780456680252 3637 3125804 SGTC_1754 st042065 16.137 µM -0.66590167198524 0.263520445883007 no 2492 0.252736975874343 3587 1126236 YIL048W NEO1 SGTC_1060 3448-7350 82 µM -0.668408683999769 0.262750291985162 no 2493 0.251936376875335 3591 570178 SGTC_2595 hexamethylquercetagetin 100 µM -0.668862832642256 0.262610900832267 no 2494 0.251791490600355 3561 386331 SGTC_1354 1498-1681 81 µM -0.669076917806043 0.262545205124342 no 2495 0.251723206631921 3660 5754243 SGTC_3068 9116768 49.47 µM -0.669345055474878 0.262462934344462 no 2496 0.251637696033097 3602 41904888 SGTC_770 0389-1121 67.2 µM -0.669707198072894 0.262351841652475 no 2497 0.251522231097265 3694 6753108 SGTC_2567 aureobasidin a 60 nM -0.669720763883665 0.262347680603845 no 2498 0.25151790634105 3690 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2997 9067075 71.4286 µM -0.670271170800784 0.262178882495865 no 2499 0.251342470742507 3618 27209819 SGTC_39 0986-0283 58.349 µM -0.670823691300091 0.262009492184235 no 2500 0.251166426548352 3663 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_865 0488-0499 301 µM -0.671822533253084 0.261703412243304 no 2501 0.250848340911646 3650 9634651 SGTC_1705 st027868 56.3335 µM -0.672066791511487 0.261628590939275 no 2502 0.250770588252446 3642 292948 SGTC_664 1222-0054 14.9 µM -0.672179744090651 0.261593994964979 no 2503 0.25073463733154 3629 6813991 SGTC_2081 5214970 32.255 µM -0.672813042209722 0.261400067103334 no 2504 0.250533119669224 3593 2063512 SGTC_2345 9052315 157.45 µM -0.673892693374881 0.261069627808186 no 2505 0.250189768867288 3633 6469265 SGTC_1133 3473-0247 50 µM -0.676419488727026 0.260297114103755 no 2506 0.249387173594462 3616 711311 SGTC_392 N-ethylmaleimide 8.33 µM -0.677224886966586 0.26005112856163 no 2507 0.249131639925483 3608 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1197 1601-0112 267 µM -0.677432964498978 0.259987596800524 no 2508 0.249065644528882 3635 7350313 SGTC_1518 st038567 90.8 µM -0.677922052804968 0.259838296289935 no 2509 0.248910558324975 3638 77966 SGTC_2641 levomentholum 100 µM -0.678048145524911 0.259799812034988 no 2510 0.248870583612024 3604 16666 SGTC_2625 euphol 100 µM -0.678949532519266 0.259524788998634 no 2511 0.24858491975539 3638 6708538 A triterpene alcohol. SGTC_2796 7949634 45.45 µM -0.680048556711411 0.259189668210417 no 2512 0.248236857996912 3627 2971588 SGTC_1817 st052116 64.4 µM -0.680409561503093 0.259079637375007 no 2513 0.248122584244235 3647 4361398 SGTC_572 0960-0087 17.7 µM -0.681247974718097 0.258824190196053 no 2514 0.247857298209311 3643 6796365 SGTC_889 0919-1524 82.7 µM -0.682222669513446 0.258527384749014 no 2515 0.247549081137765 3636 3905452 SGTC_3105 9121040 49.47 µM -0.682351634218996 0.258488126765193 no 2516 0.247508315384256 3506 41448907 SGTC_2300 7976697 71.57 µM -0.686101601098716 0.257347955789663 no 2517 0.246324520678651 3583 2236109 SGTC_208 k072-0098 12.366 µM -0.686691425561384 0.257168858844211 no 2518 0.246138600702738 3653 5948901 SGTC_1933 st074711 15.9 µM -0.687075576760254 0.257052248309733 no 2519 0.246017551970098 3647 17250958 SGTC_65 0798-0905 34.986 µM -0.687185241013899 0.257018964361858 no 2520 0.245983001856928 3761 3602145 SGTC_721 1187-1332 279 µM -0.688906776478982 0.25649675902622 no 2521 0.245440967368866 3588 25730 SGTC_198 3454-2873 16.191 µM -0.689227197319075 0.256399624591623 no 2522 0.245340152075362 3652 710957 SGTC_2281 7943571 200 µM -0.689863520893327 0.256206782216885 no 2523 0.245140009046488 3719 1244024 SGTC_971 1315-0384 26.7 µM -0.689892859008458 0.256197892916944 no 2524 0.245130783439032 3660 6769120 SGTC_2096 5468907 200 µM -0.689957652167098 0.256178261488586 no 2525 0.245110409368118 3684 759785 SGTC_2356 9061756 188.97 µM -0.690979787088821 0.255868672603866 no 2526 0.244789121760132 3640 20104043 SGTC_784 4579-0127 173 µM -0.692193480531002 0.255501317340668 no 2527 0.244407916176313 3756 1948547 SGTC_295 k015-0027 31 µM -0.692341036361852 0.255456674600411 no 2528 0.244361592596894 3630 3887424 SGTC_151 3013-0144 2.285 µM -0.692534252269826 0.255398223652617 no 2529 0.244300941678479 3621 906558 YHR107C CDC12 SGTC_2339 9000433 200 µM -0.693615493330245 0.255071259723478 no 2530 0.243961687423068 3654 2988954 SGTC_2161 5662504 8.5105 µM -0.694555959334396 0.254787043886049 no 2531 0.243666810089496 3641 2859334 SGTC_217 ketoconazole 989 nM -0.695407873645948 0.254529732214213 no 2532 0.243399863802059 3606 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2834 9001755 58.44 µM -0.696542010320235 0.254187389655078 no 2533 0.243044728844164 3621 2989575 SGTC_1785 bathophenanthroline 24 µM -0.696964183305277 0.254060017171078 no 2534 0.24291260440873 3629 72812 An iron chelator. SGTC_1736 st036774 51 µM -0.69833649811761 0.253646211815178 no 2535 0.242483389535047 3704 1272247 SGTC_1480 1070-0044 41.2 µM -0.700761102022745 0.252915967224032 no 2536 0.241726058442927 3678 3124987 SGTC_1734 st037168 69.4 µM -0.701565660266699 0.252673894311445 no 2537 0.241475036647163 3705 708907 SGTC_2325 6158266 200 µM -0.703359871820459 0.25213449747598 no 2538 0.240915753768867 3701 3623240 SGTC_3311 9131146 2.8755 µM -0.703721263219615 0.25202592530776 no 2539 0.240803187919494 3693 4900406 YPR165W RHO1 SGTC_2063 5246145 200 µM -0.704194644773779 0.25188374546608 no 2540 0.240655782787886 3698 711240 SGTC_2391 6285546 200 µM -0.70527947713247 0.251558076528283 no 2541 0.240318164805896 3670 846083 SGTC_1688 st021091 57.6 µM -0.705623974220853 0.251454704341756 no 2542 0.240211005557117 3701 3656366 SGTC_3260 9137109 49.47 µM -0.706927302183906 0.251063821922844 no 2543 0.239805828140604 3550 17478346 SGTC_2071 5230951 39.92 µM -0.709391770751511 0.250325580180085 no 2544 0.239040696538372 3730 1799272 SGTC_281 1672-3440 14.9 µM -0.709490550838983 0.250296014203535 no 2545 0.239010056606331 3701 6833000 SGTC_61 0978-8327 98.565 µM -0.709716537724889 0.250228380784008 no 2546 0.238939967327495 3696 6150059 YHR072W ERG7 SGTC_2421 5690543 90.72 µM -0.710480949461104 0.249999679274407 no 2547 0.238702970226814 3710 3397993 SGTC_895 0964-0006 13.7 µM -0.710670258844681 0.249943057643365 no 2548 0.238644296898642 3665 6738897 SGTC_968 1309-0633 340 µM -0.713650577485317 0.24905255473218 no 2549 0.23772163712805 3678 3761976 SGTC_3056 9094900 49.47 µM -0.713712283992972 0.249034135018239 no 2550 0.237702554464176 3654 25236784 SGTC_3100 9120536 49.47 µM -0.714619883076252 0.248763295718396 no 2551 0.237421977632998 3579 16421196 SGTC_1379 2144-0755 36.5 µM -0.714791817535859 0.248712005928447 no 2552 0.237368845993652 3736 5392327 SGTC_1120 ficusin 1.78878 µM -0.716372741097107 0.248240664495478 no 2553 0.236880610965768 3788 6199 A DNA cross-linker. SGTC_528 3492-0019 172 µM -0.717167203185462 0.24800398106188 no 2554 0.236635466639295 3725 2869262 SGTC_670 4204-0025 119 µM -0.717263921857476 0.247975175189181 no 2555 0.236605632037289 3727 719039 SGTC_322 k048-0136 19.3 µM -0.717519224453322 0.2478991465968 no 2556 0.236526889333518 3714 6823282 SGTC_636 0kpi-0074 126 µM -0.7191647188883 0.24740942036698 no 2557 0.236019717430934 3723 616434 SGTC_3197 9113331 49.47 µM -0.719476534177125 0.247316677313145 no 2558 0.235923677757364 3716 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3250 9135583 49.47 µM -0.719875927378998 0.247197913161205 no 2559 0.235800695398033 3726 7699353 SGTC_1684 st024538 14.6195 µM -0.720654279231895 0.246966548968093 no 2560 0.235561124542664 3697 6732859 SGTC_247 mechlorethamine 29.705 µM -0.722423250310403 0.246441155574589 no 2561 0.235017148256269 3648 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1609 st001574 46.4 µM -0.723222608791664 0.246203938674262 no 2562 0.234771565380962 3705 3960012 SGTC_1213 1315-0166 115 µM -0.723306022317883 0.246179192008572 no 2563 0.234745946840845 3732 768401 SGTC_1924 st058459 75.1 µM -0.724215545801177 0.2459094461769 no 2564 0.234466708012356 3668 688683 SGTC_2091 4-phenylthiadiazole 200 µM -0.725046600453657 0.245663111325934 no 2565 0.234211721177228 3721 270010 SGTC_1315 1237-0019 3.69 µM -0.725048187661222 0.245662640984851 no 2566 0.234211234332077 3694 825140 SGTC_2057 5236571 38.335 µM -0.726842642508497 0.245131195277805 no 2567 0.233661178613812 3713 54684039 YBR257W POP4 SGTC_1669 st015249 58.4 µM -0.727945967997449 0.244804741636706 no 2568 0.233323331226996 3782 722793 SGTC_2603 homopterocarpin 100 µM -0.728983984522484 0.24449782549092 no 2569 0.233005729610661 3757 101795 A weak amylase inhibitor. SGTC_395 anisomycin 6.25 µM -0.730169420379577 0.244147574748557 no 2570 0.232643315991161 3719 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1138 3761-0006 1.03 µM -0.730568989921232 0.24402957830045 no 2571 0.232521229504875 3687 12061087 SGTC_1401 3807-4679 7.6 µM -0.732575921619973 0.243437379030815 no 2572 0.231908560655751 3717 3291456 SGTC_3224 9130643 49.47 µM -0.733168032781293 0.243262809127214 no 2573 0.231727975005418 3743 17644395 SGTC_1675 st018485 24.5 µM -0.734627391872859 0.242832840846902 no 2574 0.23128322553326 3782 3323024 SGTC_2389 9091542 195.52 µM -0.734823546682785 0.242775079487436 no 2575 0.231223482361598 3752 3626624 YOL127W RPL25 SGTC_56 0957-0365 83.25 µM -0.735412361664799 0.242601736856114 no 2576 0.23104419780075 3682 6752360 SGTC_1692 fluoroquinolonic acid 71 µM -0.736145503358878 0.242385999251509 no 2577 0.23082107659931 3751 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_111 0083-0039 52.457 µM -0.736854251493692 0.242177538661299 no 2578 0.230605493672679 3640 759313 SGTC_1183 1254-0324 198 µM -0.737065911440307 0.242115303018072 no 2579 0.230541133992906 3779 5799357 SGTC_331 k048-0133 24.5 µM -0.738018235203835 0.241835392865805 no 2580 0.23025168405404 3707 6813582 SGTC_328 k915-0120 63.5 µM -0.738664585595838 0.241645515496197 no 2581 0.230055347716008 3737 6624543 SGTC_585 0kpi-0023 191 µM -0.740680504706557 0.241053822231897 no 2582 0.229443591319825 3675 64601 SGTC_758 0868-0029 16 µM -0.740786778182473 0.241022651734212 no 2583 0.22941136659415 3783 762687 SGTC_589 1227-0070 34.1 µM -0.742765451736827 0.240442698213302 no 2584 0.228811847713354 3749 2841384 SGTC_2746 daunorubicin 9.88 µM -0.747111459133008 0.239171546336715 no 2585 0.227498141846995 3635 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3043 9092303 49.47 µM -0.749594576554903 0.2384469179419 no 2586 0.226749459112125 3763 25236084 SGTC_1334 1486-0610 236 µM -0.74976540114774 0.238397111791022 no 2587 0.226698005087636 3822 3742339 SGTC_1413 3910-0535 34.4 µM -0.750641400541904 0.238141792211336 no 2588 0.22643424912786 3760 2876951 SGTC_625 k213-0058 121 µM -0.752696289136649 0.237543460943074 no 2589 0.22581622019223 3816 3655420 SGTC_872 0588-0139 234 µM -0.75340966736391 0.237335936454093 no 2590 0.225601887634611 3766 2047100 SGTC_1818 st052136 56.3 µM -0.753501749572403 0.237309156639692 no 2591 0.225574230175432 3638 674169 SGTC_1788 fluconazole 20 µM -0.754500432090587 0.237018821351062 no 2592 0.225274393007153 3789 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3318 9139014 38.6185 µM -0.756041868050986 0.236571081151416 no 2593 0.224812046848363 3754 16643984 SGTC_1161 k007-0610 110 µM -0.756289292885644 0.236499255144379 no 2594 0.224737883126221 3795 5843850 SGTC_2099 5377090 177.372 µM -0.756312296956065 0.236492577804822 no 2595 0.22473098853519 3769 2243829 SGTC_3170 9103054 49.47 µM -0.756322301697835 0.236489673783404 no 2596 0.224727990033595 3753 16432970 SGTC_1629 st005085 44.9 µM -0.756457419177571 0.236450455897408 no 2597 0.224687496460347 3774 24207091 SGTC_1491 4138-0063 26.5 µM -0.757032297288062 0.236283637387743 no 2598 0.224515256588805 3716 23883227 SGTC_2464 5717415 7.67 µM -0.758046611748438 0.235989461061482 no 2599 0.224211539484337 3747 5285744 SGTC_2906 7926292 26.41 µM -0.758376417605306 0.235893852691347 no 2600 0.224112835700428 3739 2966319 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.759320685480602 0.235620234268399 no 2601 0.223830373205334 3781 2724 A muscle relaxant with antifungal properties. SGTC_2523 spermine 47.74 µM -0.761967336815273 0.234854253760495 no 2602 0.22303974947931 3750 1103 A DNA binding polyamine. SGTC_2744 captopril 92.04 µM -0.76241601999793 0.23472453470815 no 2603 0.222905873958626 3718 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2736 butenafine 14.65 µM -0.764187076686476 0.234212890482595 no 2604 0.222377883384237 3750 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1611 st001856 99.4 µM -0.764600325145824 0.23409359518621 no 2605 0.222254787745076 3763 647478 SGTC_1399 3562-5772 25 µM -0.764650789638725 0.234079029557219 no 2606 0.222239758389554 3724 23847490 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.764961373739276 0.233989396335513 no 2607 0.222147272876764 3859 4213774 SGTC_2918 7977171 22.06 µM -0.765448142632511 0.233848955205871 no 2608 0.22200236738336 3718 2236483 SGTC_797 k781-0471 270 µM -0.76685544618102 0.233443186984153 no 2609 0.221583733009796 3763 23738129 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.767352319090292 0.233300016828342 no 2610 0.221436034727937 3608 88881 An O-methylated flavonoid and antioxidant. SGTC_2900 5328528 85.29 µM -0.767390304210657 0.233289073709625 no 2611 0.221424745752601 3797 795359 SGTC_2350 9023895 38.85 µM -0.768290507508044 0.233029817871182 no 2612 0.221157306450568 3807 2997209 SGTC_1036 k216-0215 33.5 µM -0.768377882230818 0.233004662735275 no 2613 0.221131358340508 3774 622330 SGTC_3342 9147791 14.508 µM -0.769371991769926 0.232718565341459 no 2614 0.220836255320282 3728 1838168 SGTC_2738 aclarubicin 5.55 µM -0.772074082791351 0.231941910882931 no 2615 0.220035275664816 3721 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2519 cryptotanshinone 88.04 µM -0.773427057357164 0.231553572149788 no 2616 0.219634841030127 3741 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_615 k087-0205 167 µM -0.774166002998521 0.231341628743524 no 2617 0.219416314968233 3790 9642773 SGTC_44 0929-0055 61.211 µM -0.774384021317723 0.23127911769571 no 2618 0.219351864972636 3756 1379590 SGTC_2257 7960413 200 µM -0.775797110766018 0.230874179805865 no 2619 0.218934395081231 3779 2974689 YIL048W NEO1 SGTC_749 1000-0129 128 µM -0.776825924749851 0.230579609923669 no 2620 0.21863073964998 3833 708470 SGTC_2235 salicylic acid 500 µM -0.776932570245167 0.230549087218191 no 2621 0.218599277004322 3797 338 A COX inhibitor and kinase inhibitor. SGTC_416 estradiol valerate 100 µM -0.776967249870351 0.230539162147338 no 2622 0.218589046353168 3828 13791 A steroid. SGTC_2685 mycophenolic acid 18.85 µM -0.777143408009089 0.230488750583666 no 2623 0.218537083137288 3788 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_200 k038-0079 37.545 µM -0.779688925890171 0.229760982294346 no 2624 0.217786999367142 3757 3436683 SGTC_844 0330-0132 15.3 µM -0.779709918170437 0.229754985917017 no 2625 0.217780819785114 3823 2828079 SGTC_2919 7978188 46.38 µM -0.779867186997055 0.229710065370334 no 2626 0.217734527145096 3752 2980291 SGTC_1579 chlormadinone acetate 49.4 µM -0.779991086181924 0.229674679627225 no 2627 0.217698060976347 3827 45114258 A steroidal progestin. SGTC_3174 9107204 49.47 µM -0.781749175449554 0.229172896561306 no 2628 0.217180997734936 3816 3938802 SGTC_543 3844-1095 191 µM -0.781819580246589 0.229152814867157 no 2629 0.217160306101008 3819 4230703 SGTC_649 1123-0311 367 µM -0.782314565399647 0.22901165717444 no 2630 0.217014864479706 3774 693629 YIL048W NEO1 SGTC_2215 7188065 200 µM -0.782534346700273 0.228948996551075 no 2631 0.21695030413165 3795 940217 SGTC_2204 7233102 200 µM -0.782951033337399 0.228830223757783 no 2632 0.216827933687178 3715 2172480 SGTC_149 3970-0822 46.1 µM -0.78477260870254 0.228311406290899 no 2633 0.216293451327146 3825 3114250 YBL034C STU1 SGTC_1172 0370-0043 85 µM -0.785396772154548 0.228133785495887 no 2634 0.216110486350261 3853 376585 SGTC_338 4055-0136 114 µM -0.78573920937078 0.228036369727993 no 2635 0.216010143656855 3761 2900563 SGTC_2265 7929201 200 µM -0.787072063355611 0.227657425263216 no 2636 0.215619841070199 3788 1265108 SGTC_1306 1185-0270 9.02 µM -0.787578308068809 0.227513587495052 no 2637 0.215471703530573 3834 1548076 SGTC_282 k297-0036 65.7 µM -0.790353810413217 0.226725902601551 no 2638 0.214660584625208 3802 5061378 SGTC_639 0833-0042 114 µM -0.790710753559488 0.226624714277728 no 2639 0.214556399711649 3795 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_901 1112-0062 60.1 µM -0.790724537137365 0.226620807339954 no 2640 0.214552377137055 3811 1908457 SGTC_1932 st074806 40.9 µM -0.790829201498768 0.226591141599053 no 2641 0.214521833508367 3881 17251235 SGTC_2797 7859098 81.82 µM -0.791564525146509 0.226382785562372 no 2642 0.214307319303472 3838 972681 SGTC_503 tyrphostin 8 294 µM -0.79193182981094 0.226278749283705 no 2643 0.214200213139587 3770 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2646 retinol 96.75 µM -0.793581124456209 0.225811932073614 no 2644 0.213719662315358 3797 445354 A vitamin A analog and teratogen. SGTC_3244 9134489 49.47 µM -0.794889165073982 0.225442091196928 no 2645 0.213338988723839 3835 16584271 SGTC_1082 camptothecin 424.86 nM -0.794992749563301 0.225412817945082 no 2646 0.213308859864168 3761 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1159 4092-0538 61.2 µM -0.795022928310621 0.22540428975575 no 2647 0.21330008246027 3846 717301 SGTC_1621 st003705 32.4 µM -0.797029220777169 0.224837742982954 no 2648 0.212717030444377 3863 24207032 SGTC_1789 tunicamycin 25 nM -0.797984884698681 0.224568162015199 no 2649 0.212439630860424 3772 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2199 6590217 200 µM -0.799841652366592 0.224044915447438 no 2650 0.211901273460613 3752 703109 SGTC_75 0159-0059 199.013 µM -0.79992217620412 0.224022239100616 no 2651 0.21187794418147 3865 5377270 SGTC_786 4544-0069 423 µM -0.801772833211368 0.223501434385756 no 2652 0.21134218806722 3875 748821 YLR208W SEC13 SGTC_2914 7968218 45.32 µM -0.801797081474537 0.223494615107886 no 2653 0.211335173584998 3824 2977111 SGTC_1283 0922-0125 16.4 µM -0.802033959329127 0.223428004772333 no 2654 0.211266657273441 3842 3360884 SGTC_848 0368-0089 85.6 µM -0.802757611228516 0.223224582968184 no 2655 0.211057423442327 3846 762535 SGTC_499 genistein 192 µM -0.804427617651675 0.22275553925113 no 2656 0.210575028272655 3840 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_945 3381-0768 11.3 µM -0.80477723128195 0.222657416718139 no 2657 0.210474121447736 3877 1126236 YIL048W NEO1 SGTC_1400 3771-8998 51.5 µM -0.805176941666123 0.222545264226549 no 2658 0.210358790286284 3751 670767 SGTC_2829 7992743 58.44 µM -0.806703767095889 0.222117157486025 no 2659 0.20991858662707 3903 16462845 SGTC_2884 9058502 51.95 µM -0.807463692645977 0.221904257205255 no 2660 0.209699692132678 3832 6471554 SGTC_1961 st076550 68.7 µM -0.808797667332489 0.221530813647718 no 2661 0.209315769101149 3862 1579337 SGTC_2963 9082507 9 µM -0.808936030975002 0.221492099595039 no 2662 0.20927597120753 3885 16459611 SGTC_2865 9030313 51.95 µM -0.811696233350994 0.220720605416506 no 2663 0.208482978106767 3795 42562754 SGTC_556 4058-0063 51.5 µM -0.812254470229886 0.220564761969819 no 2664 0.208322814976042 3905 6615692 SGTC_1409 3909-8004 61.9 µM -0.814339337761313 0.219983285520863 no 2665 0.207725290004336 3858 2119279 SGTC_2021 4019055 173 µM -0.816332296568673 0.219428265885102 no 2666 0.207155053716337 3808 44827708 YER133W GLC7 SGTC_1991 st073000 8.92 µM -0.817121163148886 0.219208796671965 no 2667 0.206929594927143 3939 4301969 YIL048W NEO1 SGTC_2953 9074162 66.49 µM -0.817575433950764 0.219082472049661 no 2668 0.206799829833557 3800 16451992 SGTC_2225 6654152 15.4 µM -0.822973907272956 0.217584460686674 no 2669 0.205261415861588 3759 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1724 st037281 8.293 µM -0.823266343050607 0.217503482414236 no 2670 0.205178274428194 3863 574124 YDL195W SEC31 SGTC_3216 9129716 49.47 µM -0.825182887379309 0.216973203681857 no 2671 0.204633883653865 3848 8056934 SGTC_836 0330-0104 1.35 µM -0.825319200331173 0.216935516440503 no 2672 0.20459519698052 3859 46494820 SGTC_953 1188-0045 9.7 µM -0.825545397810796 0.216872986646139 no 2673 0.204531009983772 3915 6144426 SGTC_1828 st055811 49 µM -0.827749787010656 0.216264153399596 no 2674 0.203906108491904 3914 5877589 SGTC_3150 9097574 49.47 µM -0.827818973994101 0.216245060582623 no 2675 0.203886513760565 3863 17217476 SGTC_2958 9077254 16.72 µM -0.827890047715744 0.21622544811825 no 2676 0.203866385846874 3915 16457351 SGTC_3287 9117173 37.0625 µM -0.829108141293366 0.215889480952081 no 2677 0.2035216086691 3851 2789709 SGTC_862 0452-0056 10.2 µM -0.830943865499227 0.215383734537335 no 2678 0.203002670788634 3835 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_191 3914-0123 66.505 µM -0.832216998589025 0.215033387350552 no 2679 0.202643235348113 3822 3144412 SGTC_1930 st074634 34.3 µM -0.836940726382568 0.21373638315541 no 2680 0.201312943277041 3817 684253 YOR116C RPO31 SGTC_1327 1436-0082 2.18 µM -0.838853873043883 0.213212385499492 no 2681 0.200775657508154 3896 15992205 SGTC_934 2950-0684 338 µM -0.840660272952233 0.212718313371267 no 2682 0.200269141160674 3954 1121253 SGTC_20 0481-0013 4.944 µM -0.841835097684554 0.212397343719436 no 2683 0.199940131581153 3917 182045 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.841965728069968 0.212361672150704 no 2684 0.199903568640977 3892 676296 Flavone; oxidizing agent. SGTC_740 k014-0057 261 µM -0.842219549012279 0.212292370636542 no 2685 0.199832536637622 3903 4012779 SGTC_660 4031-1742 102 µM -0.843007331741046 0.21207736408225 no 2686 0.199612171677557 3818 6738706 SGTC_1246 0422-0085 105 µM -0.843106259051819 0.212050373228104 no 2687 0.199584509268096 3930 264295 SGTC_2995 9067767 71.4286 µM -0.844887616840762 0.211564699944178 no 2688 0.199086794494876 3935 11673567 SGTC_1847 st056231 15 µM -0.847037826078631 0.210979330533928 no 2689 0.198487019014811 3893 5393180 SGTC_1624 st003710 6.25 µM -0.847398036143792 0.210881360481633 no 2690 0.198386649378988 3920 24207033 SGTC_2761 levamisole 97.89 µM -0.849013650409528 0.210442273456347 no 2691 0.197936848329101 3847 26879 An alkaline phosphatase inhibitor. SGTC_938 3126-1755 342 µM -0.852210490543759 0.209575028632387 no 2692 0.197048637580154 3948 1777771 SGTC_559 1550-0661 158 µM -0.852398185414178 0.209524175833446 no 2693 0.196996563478357 3970 5830875 SGTC_1860 st056228 74.6 µM -0.853482579623835 0.209230519426293 no 2694 0.196695872050194 3888 688679 SGTC_2860 9025725 38.96 µM -0.853665380177568 0.209181040496461 no 2695 0.196645210720835 3906 40546248 SGTC_3199 9111318 49.47 µM -0.853946909818018 0.209104851876084 no 2696 0.196567203083536 3875 8548020 SGTC_21 0849-0113 22.993 µM -0.855854310491146 0.208589094394989 no 2697 0.196039184969807 3858 1560156 SGTC_3059 1327-0034 3 µM -0.856835698112343 0.208324021528765 no 2698 0.195767846886545 3838 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1625 st003711 30.1 µM -0.858611533862693 0.207844873590975 no 2699 0.195277436302081 3966 24207034 YER133W GLC7 SGTC_3009 9080819 71.4286 µM -0.859288876107987 0.207662287780968 no 2700 0.195090579901257 3931 17027216 SGTC_1451 4152-0210 104 µM -0.859500014148855 0.207605392343016 no 2701 0.195032356101491 3880 659563 SGTC_495 decylubiquinone 155 µM -0.859724594347272 0.20754488475278 no 2702 0.194970437064042 3964 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2308 7584454 197.62 µM -0.86085879305257 0.207239462175106 no 2703 0.194657909632015 3937 893577 SGTC_1806 st050005 60.3 µM -0.861738738965547 0.207002689243866 no 2704 0.194415651427211 3939 5194765 SGTC_2748 diazoxide 86.69 µM -0.862547680054663 0.206785163334512 no 2705 0.194193103585379 3920 3019 A potassium channel activatior. SGTC_2616 abietic acid 100 µM -0.863248059011251 0.206596939351179 no 2706 0.194000547656711 3929 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1874 staurosporine 7.6 µM -0.863262824181827 0.206592972364375 no 2707 0.193996489505286 3974 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1299 1079-1439 3.74 µM -0.86351478922009 0.206525283386602 no 2708 0.193927245838177 3870 323161 SGTC_2868 9035608 32.47 µM -0.863541115043518 0.206518211861623 no 2709 0.193920011987138 3883 6462614 SGTC_3131 9127911 49.47 µM -0.867189699864667 0.205539533457234 no 2710 0.192919039459077 3963 45595681 SGTC_493 zm226600 134 µM -0.867229351220509 0.20552891272048 no 2711 0.192908178654164 3955 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2430 5571206 200 µM -0.86803588435812 0.205312951084702 no 2712 0.192687344217529 3950 1731771 SGTC_83 0170-0301 39.027 µM -0.8702884144419 0.204710515937662 no 2713 0.192071404351158 3854 3089716 SGTC_3042 9091578 49.47 µM -0.87034607075025 0.204695109675346 no 2714 0.192055654434384 3874 25236497 SGTC_274 sirtinol 40.1 µM -0.870722097145259 0.204594649101825 no 2715 0.191952955061551 3996 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_737 1950-0117 57.9 µM -0.87225769371043 0.204184698184539 no 2716 0.191533905855219 3867 5393513 SGTC_2241 6772625 37.8075 µM -0.873174657847465 0.203940134081382 no 2717 0.191283942817154 3832 2285411 SGTC_3253 9135987 49.47 µM -0.875259846552156 0.203384642238169 no 2718 0.190716268335904 3914 4182430 SGTC_458 nppb 133 µM -0.875500694270206 0.203320538895847 no 2719 0.190650766313682 3940 4549 A chloride channel blocker. SGTC_1830 st055982 50.3 µM -0.875573735452577 0.203301100845755 no 2720 0.190630904436327 3839 455313 An antimicrobial agent. SGTC_2851 9015922 71.43 µM -0.876331864806196 0.203099409530882 no 2721 0.19042482353234 3945 2996893 SGTC_1664 st014217 9.02 µM -0.877871719397363 0.202690117421052 no 2722 0.190006669051023 3965 3982782 SGTC_2629 bisabolol 100 µM -0.879895857636801 0.20215285356789 no 2723 0.189457864483413 3977 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.88085378990797 0.201898888424559 no 2724 0.189198480734712 3960 91467 include heat shock SGTC_2041 5107442 45.335 µM -0.881785005946132 0.201652189421349 no 2725 0.188946540771454 3972 793005 SGTC_1019 4262-0212 3.4 µM -0.882454718431681 0.201474879966043 no 2726 0.188765478279471 3974 4677213 SGTC_822 1487-0950 154 µM -0.882741130115904 0.201399079687287 no 2727 0.188688077089932 3960 1958375 SGTC_2702 st077768 96.8 µM -0.883148467659591 0.20129130522272 no 2728 0.188578030051806 3931 6484119 SGTC_3015 9080845 49.47 µM -0.883354836540953 0.20123671678613 no 2729 0.188522292172253 4016 5296973 SGTC_2318 6029776 164 µM -0.883814923391372 0.201115047148815 no 2730 0.188398064540612 3948 818325 SGTC_426 0988-0037 14.6 µM -0.884149381091643 0.201026627748924 no 2731 0.188307789622686 3969 5383008 SGTC_1483 3453-0561 55.9 µM -0.884574303558669 0.20091432613646 no 2732 0.18819313546729 3958 4546991 SGTC_480 am 92016 50 µM -0.885789349879927 0.200593412593266 no 2733 0.18786552493548 3911 2129 K+ channel blocker. SGTC_66 0109-0187 42.4 µM -0.886394323185293 0.200433744115747 no 2734 0.18770253859023 3886 759417 SGTC_13 0199-0087 65 µM -0.888095446739803 0.199985181861229 no 2735 0.187244705848655 3992 4589825 SGTC_1276 0871-0068 94.2 µM -0.888768649323728 0.199807834673005 no 2736 0.187063713997065 3963 3414906 SGTC_955 1216-0110 33 µM -0.891266364282801 0.199150668518639 no 2737 0.186393144459022 3919 3619719 SGTC_827 3253-0474 693 µM -0.893649947433739 0.198524746938625 no 2738 0.1857546067077 3974 5402065 SGTC_1026 k007-1105 30.6 µM -0.894303186058362 0.19835341589104 no 2739 0.185579847878775 3946 7066794 SGTC_987 1497-1013 404 µM -0.895226489346156 0.198111404686452 no 2740 0.185333013600817 3903 1676435 SGTC_1690 st023502 41.2 µM -0.895332501340204 0.198083628817777 no 2741 0.185304685592216 3955 24207482 SGTC_2089 5281248 129.67 µM -0.896048532843865 0.197896085244097 no 2742 0.185113421553152 3949 2737878 SGTC_665 3914-0008 307 µM -0.89610025828653 0.197882541428102 no 2743 0.18509960956962 3912 1069549 SGTC_1769 st044406 64.4 µM -0.896241394311607 0.197845589148603 no 2744 0.185061925986678 3956 670903 SGTC_1796 st049173 110.4 µM -0.897020046716629 0.197641797081318 no 2745 0.184854110027371 3890 94134 SGTC_130 0136-0219 337.655 µM -0.902133799132256 0.196306560585757 no 2746 0.183492898133416 3838 234244 SGTC_1066 ketoconazole 628 nM -0.903571894919262 0.195932051169537 no 2747 0.183111224848902 4029 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_15 0266-0086 27.098 µM -0.904242900480403 0.195757456083708 no 2748 0.182933308303137 4043 1712902 YIL048W NEO1 SGTC_396 dithiazanine 1.25 µM -0.904987224008773 0.195563894236777 no 2749 0.182736077812618 3971 10578 An antihelmenthic. SGTC_516 3992-2719 87.3 µM -0.905014041810738 0.195556922418635 no 2750 0.182728974123001 3914 5350887 YDR037W KRS1 SGTC_2664 lyso-paf C-16 73.48 µM -0.907832480870642 0.194825055084501 no 2751 0.181983367363471 3951 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1832 st054113 55 µM -0.908013552725452 0.194778092966835 no 2752 0.181935530654985 3996 1251267 SGTC_283 0987-0079 11.7 µM -0.908614255767061 0.194622346196873 no 2753 0.181776889447585 3992 411556 SGTC_2745 rifampicin 24.3 µM -0.909079472406389 0.194501779633194 no 2754 0.181654088670694 3978 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2815 7968870 71.43 µM -0.909413959211247 0.194415121399152 no 2755 0.181565828044181 3979 2977326 YHR190W ERG9 SGTC_1687 st020778 55.3625 µM -0.910225356121279 0.194205003845735 no 2756 0.181351837270617 3992 4259299 SGTC_3240 9133527 49.47 µM -0.910558738554453 0.194118711969502 no 2757 0.181263959673439 3921 17617455 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.910770607562652 0.194063884465024 no 2758 0.181208126143106 3927 5711223 A potent inhibitor of glutathione S-transferases. SGTC_790 1575-0012 79.1 µM -0.911048635971183 0.193991950532767 no 2759 0.181134874066712 4056 378741 YLR208W SEC13 SGTC_2220 6782180 200 µM -0.911243975105173 0.19394142040895 no 2760 0.181083419209301 3897 833803 SGTC_2902 5787006 60.46 µM -0.912422314143719 0.193636779050227 no 2761 0.180773223708441 3947 591003 SGTC_3208 9114115 49.47 µM -0.913417576450063 0.193379696813783 no 2762 0.180511482470692 4017 650895 SGTC_1424 4048-1941 275 µM -0.913932052972703 0.193246886124307 no 2763 0.180376274981666 4056 X1424 SGTC_2820 7989630 71.43 µM -0.91567817501023 0.192796544818111 no 2764 0.179917857694239 3949 2984098 SGTC_1253 0550-0034 176 µM -0.915708988578256 0.192788603470323 no 2765 0.179909774644759 4014 5969915 SGTC_1020 4335-0961 93.3 µM -0.91676698346173 0.192516055696171 no 2766 0.179632378610362 3925 669075 SGTC_3076 9116187 49.47 µM -0.916781483701917 0.192512321957607 no 2767 0.179628578655519 3991 27241210 SGTC_1825 st052143 62.6 µM -0.916943581040771 0.192470585725623 no 2768 0.179586102620844 4018 674173 SGTC_1043 0916-0009 19.3 µM -0.917196690261183 0.192405427149863 no 2769 0.179519790430526 4032 3101130 SGTC_2980 9014342 25.29 µM -0.918275143384061 0.192127949310944 no 2770 0.17923741857119 4056 2996599 SGTC_399 oxolinic acid 75 µM -0.918423182684817 0.192089879037489 no 2771 0.179198679191016 3953 4628 A DNA gyrase inhibitor. SGTC_2754 granisetron 64.02 µM -0.918753330269661 0.192004993825612 no 2772 0.179112304124265 3987 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1602 st001878 87.6 µM -0.918795589353296 0.191994130126456 no 2773 0.179101249956382 4008 595405 YLR310C CDC25 SGTC_957 1187-1561 14.1 µM -0.920210706615004 0.191630557938178 no 2774 0.178731330198535 3955 1538454 SGTC_1038 k292-0204 154 µM -0.921963985602993 0.19118069050868 no 2775 0.178273680738971 3949 4454212 SGTC_704 1310-0270 142 µM -0.922239676152133 0.191110011038423 no 2776 0.178201785890689 4011 5718033 SGTC_234 nsc-17383 10.7 µM -0.923219219790504 0.19085901263328 no 2777 0.177946487395013 3985 408974 SGTC_3194 9111903 49.47 µM -0.923277580501118 0.190844064662974 no 2778 0.177931284124614 4037 17087251 SGTC_3151 9099821 49.47 µM -0.924041704882957 0.190648415217939 no 2779 0.177732301307503 3980 17174189 SGTC_277 nystatin 15.5 µM -0.925641374609045 0.190239228255971 no 2780 0.177316192001619 3988 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2002 4023503 131 µM -0.926478941484169 0.190025198498637 no 2781 0.177098567987939 3986 4736863 YCR052W RSC6 SGTC_2827 7993847 71.43 µM -0.927241476817746 0.189830470878029 no 2782 0.176900586132707 4081 2985692 SGTC_342 k048-0088 23.3 µM -0.92733767807661 0.189805912811549 no 2783 0.176875618733803 3989 6820570 SGTC_1216 1165-0504 9.65 µM -0.927454170334027 0.189776177514571 no 2784 0.176845388133168 4051 6304004 SGTC_2661 dactinomycin 12.96 µM -0.931763724406803 0.188678153975265 no 2785 0.175729322805547 3984 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1925 st057770 10.1 µM -0.932067123822933 0.188600999224161 no 2786 0.175650918532429 3993 5989122 SGTC_3233 9132340 49.47 µM -0.932647994556533 0.188453337541819 no 2787 0.175500872159607 4016 17682950 SGTC_3011 9081274 71.4286 µM -0.932989841049708 0.188366470944582 no 2788 0.175412606803691 4009 6625322 SGTC_360 0957-0399 1.01 µM -0.933524092962904 0.188230761687668 no 2789 0.175274718404384 4039 6752301 YPR165W RHO1 SGTC_1402 3909-7673 35.9 µM -0.935632467878396 0.187695786924185 no 2790 0.174731225902908 4008 5328014 SGTC_1891 st059073 26.2 µM -0.937909760662239 0.187119007584854 no 2791 0.174145393339358 4108 688754 SGTC_1760 st045453 10.4495 µM -0.938476724404685 0.186975580954251 no 2792 0.173999736485345 4077 3323419 YIL048W NEO1 SGTC_683 panaxydol 45 µM -0.939561725171406 0.186701294534903 no 2793 0.173721208405003 3997 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2549 cedrol 20.94 µM -0.940278164823546 0.186520316377099 no 2794 0.173537448373353 3959 6708665 A sedative which affects the nervous system. SGTC_3117 9124945 49.47 µM -0.940982812761162 0.186342422912576 no 2795 0.17335683351586 3924 17592065 SGTC_1361 1608-0041 5.61 µM -0.941582693446849 0.186191061560675 no 2796 0.173203166867885 3989 X1361 SGTC_3071 9117417 49.47 µM -0.942201790973141 0.186034931352996 no 2797 0.173044668581486 3954 45595590 YGL055W OLE1 SGTC_1360 1598-0022 39.8 µM -0.945377753068931 0.185235262281929 no 2798 0.172233027891908 4075 761525 SGTC_2126 5251174 33.877 µM -0.946511397353182 0.184950342008944 no 2799 0.171943905920856 4052 790722 SGTC_3200 9114385 49.47 µM -0.948735730622816 0.18439208935632 no 2800 0.171377518274205 4090 17018030 YLR208W SEC13 SGTC_1803 st050068 52.4 µM -0.949185262640803 0.184279395401215 no 2801 0.171263197816712 4087 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1723 st034307 2.5525 µM -0.94942289093128 0.184219841275752 no 2802 0.171202786285578 4079 867466 SGTC_492 tmb-8 126 µM -0.949779445323528 0.184130504501924 no 2803 0.171112166091749 3958 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1700 st030840 7.9285 µM -0.950488555109448 0.183952913091169 no 2804 0.170932033262995 4072 5499307 SGTC_811 0416-0114 265 µM -0.950504514788547 0.183948917332789 no 2805 0.170927980474666 4104 6612453 SGTC_1433 4060-0023 7.6 µM -0.951678155229313 0.183655226003373 no 2806 0.170630115647787 4047 3840627 SGTC_3261 9137475 49.47 µM -0.951733495013855 0.183641385014039 no 2807 0.170616078860328 3953 17027690 SGTC_364 0083-0097 67.7 µM -0.952525038286563 0.183443483899808 no 2808 0.170415386950794 4128 5207356 SGTC_1435 4092-0789 56.7 µM -0.955228973007005 0.182768451263605 no 2809 0.16973095853296 4024 2248285 SGTC_1504 k297-0033 30 µM -0.955694184110535 0.182652468655544 no 2810 0.169613380838959 3933 4388117 SGTC_2759 disulfiram 3.38 µM -0.955771814073327 0.182633119066728 no 2811 0.169593765690366 3947 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1086 cerivastatin 2.18 µM -0.956336595135831 0.182492383588857 no 2812 0.169451103461459 4014 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1445 4239-0156 97.7 µM -0.958814852712558 0.181875637853005 no 2813 0.168826012727074 4145 4008346 SGTC_529 4076-0302 30.3 µM -0.959777588518289 0.181636400868684 no 2814 0.168583582032637 3992 5816522 SGTC_1710 st031758 61.5 µM -0.960062380633776 0.181565668634114 no 2815 0.168511910203387 4074 5394341 SGTC_2802 7925815 54.55 µM -0.961868894373375 0.181117396447434 no 2816 0.168057732683601 4019 1262923 SGTC_1980 st071811 45.7 µM -0.963137570545919 0.180802999218723 no 2817 0.167739244785553 4145 4974850 SGTC_2941 9056145 11.23 µM -0.968345395279764 0.179516008801799 no 2818 0.166435950225108 3914 2119517 SGTC_2976 9009005 19.48 µM -0.969236401408022 0.179296396019376 no 2819 0.166213626427322 4073 2993148 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.969724024463197 0.179176279568697 no 2820 0.166092036004831 4045 689007 SGTC_2139 5578692 56.4705 µM -0.974148026970601 0.178088826438685 no 2821 0.164991523006055 4017 650991 YMR113W FOL3 SGTC_2843 9000894 45.46 µM -0.974351184020494 0.178038989031992 no 2822 0.164941099389663 3974 2242070 SGTC_2665 lovastatin 100 µM -0.976297200356619 0.177562048276076 no 2823 0.164458603463962 4083 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1778 st046819 58.9 µM -0.978237354256764 0.177087347830026 no 2824 0.163978472757011 4121 671715 SGTC_2863 9028737 58.44 µM -0.980193383892564 0.176609575446592 no 2825 0.163495334870404 4034 6460917 SGTC_2520 obtusaquinone 4.71 µM -0.981385413294308 0.176318814985115 no 2826 0.163201358304733 4121 5967872 SGTC_54 0159-0055 9 µM -0.98286848390083 0.175957486707745 no 2827 0.162836085405418 4077 3319099 SGTC_1473 k844-0725 134 µM -0.983123277006271 0.175895457355738 no 2828 0.162773384688553 4122 54682906 SGTC_1871 st057448 67.3 µM -0.987743237928657 0.174773131254026 no 2829 0.161639206489125 4137 691747 SGTC_2847 9005661 71.43 µM -0.987894954742698 0.174736351977911 no 2830 0.161602048310405 4062 2991449 SGTC_2309 7664088 163.95 µM -0.993304807761178 0.173428104503911 no 2831 0.160280717649056 4105 704922 SGTC_817 1391-0715 46 µM -0.993855916962691 0.173295182338669 no 2832 0.16014650929468 4074 1353946 SGTC_2608 thymoquinone 42.66 µM -0.995182145179222 0.172975574978393 no 2833 0.159823842021161 4072 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_319 1348-1596 45.5 µM -0.997526373712921 0.172411559259047 no 2834 0.159254539364078 4183 5380505 SGTC_2840 9008771 71.43 µM -0.997770621492693 0.172352861387322 no 2835 0.1591952995764 4029 2992978 SGTC_2701 st077767 14.721 µM -0.99789410854027 0.172323189708621 no 2836 0.159165354556654 4063 5721188 SGTC_1022 4477-0945 21.3 µM -1.00106349191694 0.171562760231428 no 2837 0.158398056858035 4043 4648966 SGTC_1893 st059353 36.1 µM -1.00111369117771 0.171550733208503 no 2838 0.158385923329382 4099 3112488 SGTC_668 1682-0499 62.6 µM -1.00175679113122 0.171396703345478 no 2839 0.158230535307363 4069 682214 SGTC_505 gw-5074 63.9 µM -1.00451314397356 0.170737526796437 no 2840 0.1575656694925 4133 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_746 1095-0025 46.6 µM -1.0055901175655 0.170480412045559 no 2841 0.157306389836038 4099 6749286 SGTC_3299 9121982 43.1275 µM -1.00622849629465 0.170328123755365 no 2842 0.157152833666306 4155 17594604 YPL160W CDC60 SGTC_2329 6138490 200 µM -1.00674441044986 0.170205113663672 no 2843 0.157028807276708 4215 720019 SGTC_1570 verbenone 133 µM -1.01103381923011 0.169184589082622 no 2844 0.156000121783036 4123 29025 A natural terpanoid with antifungal properties. SGTC_1800 st050079 29.0735 µM -1.01185797323464 0.168988959453022 no 2845 0.155802983095616 3968 3645560 SGTC_2938 9059746 27.26 µM -1.01214541162902 0.168920764321987 no 2846 0.15573426611694 4101 6471769 SGTC_916 4466-0038 42 nM -1.01447708087148 0.168368226276051 no 2847 0.155177580123381 4178 5722064 YGL116W CDC20 SGTC_1471 k673-0312 37 µM -1.01702451515133 0.1677658883937 no 2848 0.154570883663182 4053 24099884 SGTC_718 1130-0073 349 µM -1.01919054991079 0.167254824842109 no 2849 0.154056256092548 4161 6740020 SGTC_1284 0929-0043 16 µM -1.01935600809607 0.167215827224651 no 2850 0.154016991586211 4080 1239883 SGTC_244 nsc-207895 1.295 µM -1.01947741818041 0.167187215239949 no 2851 0.153988184246908 3892 42640 SGTC_2238 6671620 73.2395 µM -1.02069060166169 0.166901484930755 no 2852 0.153700524330804 4042 729941 SGTC_1106 tegaserod maleate 11.7 µM -1.02086815608527 0.166859693555875 no 2853 0.153658453974355 4117 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2267 7931562 200 µM -1.02214311262891 0.166559802521306 no 2854 0.153356585332255 4050 934880 SGTC_382 3229-0966 23.2 µM -1.02287867652302 0.166386943985681 no 2855 0.153182606330738 4148 5722370 SGTC_444 curcumin 90.4 µM -1.02543709470304 0.165786614641064 no 2856 0.1525784963668 4061 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_132 0417-1715 25.805 µM -1.02707279164402 0.165403535309392 no 2857 0.152193094683116 4087 6769098 SGTC_1174 0739-0097 51.1 µM -1.02934412437762 0.164872540944631 no 2858 0.151658997823244 4153 728447 SGTC_3214 9129694 49.47 µM -1.02976607828732 0.164774017886019 no 2859 0.151559914048359 4177 17158655 SGTC_2644 guaiazulene 100 µM -1.03080456793289 0.164531700851162 no 2860 0.15131623786689 4120 3515 A coloring agent. SGTC_474 dl-dihydrosphingosine 5 µM -1.03121175042832 0.164436753572142 no 2861 0.151220765769417 4143 3058739 A sphingolipid protein kinase C inhibitor. SGTC_652 0437-0092 114 µM -1.03144872055845 0.164381512959812 no 2862 0.151165221822731 4063 3091274 SGTC_325 2810-4341 181 µM -1.03551577611247 0.163435308399946 no 2863 0.150214051352228 4126 774970 SGTC_2967 9089538 49.85 µM -1.03706899183651 0.163074886542044 no 2864 0.149851852548326 4145 728216 SGTC_899 1083-0020 478 µM -1.03971941699439 0.162461052435565 no 2865 0.1492351384326 4193 767123 SGTC_1490 4089-0339 670 nM -1.04287094038412 0.161733124333279 no 2866 0.14850403502676 4100 742542 SGTC_1776 st049249 45.9 µM -1.04411027885193 0.161447449379769 no 2867 0.148217185388823 4152 1822314 SGTC_1375 2910-0797 186 µM -1.04529878493467 0.161173800858335 no 2868 0.147942449536932 4139 742508 SGTC_199 4063-0024 41.6 µM -1.04563987041117 0.161095323281511 no 2869 0.147863666987391 4142 306215 SGTC_2915 7971052 15.16 µM -1.04830998028819 0.160481841238428 no 2870 0.147247906449237 4056 5741558 SGTC_93 0109-0045 59.227 µM -1.04965203410677 0.160174069303202 no 2871 0.146939062133431 4242 88733 SGTC_831 k061-1017 217 µM -1.05037393507925 0.160008676140972 no 2872 0.146773112254706 4169 1240153 SGTC_2570 licareol 100 µM -1.05223855555024 0.159581993958922 no 2873 0.146345057173426 4149 443158 SGTC_730 1436-0052 41.2 µM -1.0523591626995 0.159554421019889 no 2874 0.14631739865985 4184 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2121 5257820 149.641 µM -1.05286396023731 0.159439049166482 no 2875 0.146201672888539 4194 791256 SGTC_1610 st001799 48.1 µM -1.05681399078505 0.15853815295715 no 2876 0.145298243910457 4075 621897 SGTC_3190 9110366 49.47 µM -1.05723486372319 0.158442360298067 no 2877 0.145202206085269 4157 17123768 SGTC_1200 1643-0193 18.4 µM -1.0601621699094 0.157777142250811 no 2878 0.144535414104791 4182 5403974 SGTC_548 1436-0017 110 µM -1.06264735396347 0.157213836426841 no 2879 0.143970951878026 4218 9677137 SGTC_2779 methotrexate 400 µM -1.06410113753299 0.156884927454558 no 2880 0.14364144280797 4182 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_874 0599-0792 117 µM -1.06498196991047 0.156685865340504 no 2881 0.143442044483385 4189 765305 SGTC_2499 avocadenofuran 51.48 µM -1.06515559892047 0.156646645991617 no 2882 0.143402761296773 4124 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_943 3253-1379 105 µM -1.06574653358649 0.156513214000245 no 2883 0.143269118045662 4182 668464 SGTC_3017 9080681 49.47 µM -1.06632689060404 0.156382243282861 no 2884 0.143137948884781 4174 16451914 SGTC_84 0443-0269 128.823 µM -1.0686108888361 0.155867508504618 no 2885 0.142622519980154 4080 6150058 SGTC_2991 9074669 71.4286 µM -1.0697241510492 0.155617022780256 no 2886 0.14237174606516 4156 17333109 SGTC_3030 9087619 49.47 µM -1.07003038553088 0.155548166136094 no 2887 0.142302815901494 4197 25236973 SGTC_1768 st044301 37.178 µM -1.07050763503217 0.155440896938981 no 2888 0.142195437075837 4163 3931349 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.0731721212692 0.154842909640183 no 2889 0.141596948351445 4193 688664 SGTC_1913 st060213 96.1 µM -1.07319001929826 0.154838897953065 no 2890 0.141592933929911 4212 688959 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.07408430164699 0.154638539782853 no 2891 0.141392449888957 4154 3256 An antibiotic and ribosome inhibitor. SGTC_2311 7694451 200 µM -1.07429257660166 0.15459190173609 no 2892 0.141345785553888 4154 2163142 SGTC_679 0422-0091 41.4 µM -1.0764662283524 0.154105720772738 no 2893 0.14085939839278 4176 627384 YHR062C RPP1 SGTC_3319 9138450 16.7555 µM -1.07658784720596 0.154078548180746 no 2894 0.14083221793534 4101 2029690 SGTC_1115 galangin 695.678 nM -1.07843129092639 0.153667066441075 no 2895 0.140420664551141 4236 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1154 4088-0362 150 µM -1.08162726005664 0.152955408250828 no 2896 0.139709093290763 4174 6618304 SGTC_2708 st078559 56 µM -1.08175330323839 0.152927386612165 no 2897 0.139681080559503 4113 17250902 SGTC_2505 galangin 7.89 µM -1.08239155627017 0.152785543883224 no 2898 0.139539289309677 4061 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3257 9139206 32.98 µM -1.08475717424037 0.152260579905593 no 2899 0.139014608881061 4174 4910041 SGTC_551 k048-0028 34.9 µM -1.08556013094961 0.152082665025773 no 2900 0.138836823406896 4171 6836383 SGTC_824 1304-0008 100 µM -1.08582522157145 0.152023957981443 no 2901 0.138778162770618 4203 768245 SGTC_2043 5101342 149 µM -1.08717562919956 0.151725129989651 no 2902 0.138479599561596 4186 678451 SGTC_1496 4469-0713 57.4 µM -1.08804739930712 0.151532425862447 no 2903 0.138287091540547 4164 746691 SGTC_1489 4065-0444 182 µM -1.08910813370453 0.15129817085602 no 2904 0.138053101752504 4167 2877968 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.08946361142388 0.151219720258432 no 2905 0.137974746564305 4285 5282309 SGTC_2790 5423970 71.43 µM -1.08969957553153 0.151167660138901 no 2906 0.137922751585626 4246 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_88 0180-0332 8.668 µM -1.09065466092676 0.150957064060573 no 2907 0.137712433904486 4261 3101745 SGTC_193 1273-0060 1.558 µM -1.09353971566527 0.150322096556537 no 2908 0.13707845064371 4001 2847393 YHR072W ERG7 SGTC_12 0849-0099 9.267 µM -1.09381665468904 0.15026123920638 no 2909 0.137017699079378 4093 6071388 SGTC_3277 9138724 49.47 µM -1.09942676471564 0.149031952976204 no 2910 0.135790980874734 4157 15943418 SGTC_2716 st080858 38.6235 µM -1.09990116771331 0.14892831082905 no 2911 0.135687592945574 4172 5296050 SGTC_365 0121-0052 13.6 µM -1.10007803869911 0.148889682403911 no 2912 0.135649060775585 4216 3101739 SGTC_1145 3546-0597 10.2 µM -1.10381344824164 0.148075436879042 no 2913 0.134837034968243 4167 875334 SGTC_700 3453-2283 142 µM -1.10388352552468 0.148060189947295 no 2914 0.134821833083715 4248 565664 SGTC_3149 9097855 49.47 µM -1.10571261984906 0.147662599830082 no 2915 0.134425463001669 4210 25236625 YMR079W SEC14 SGTC_974 1326-0144 138 µM -1.1079028843333 0.147187443819501 no 2916 0.133951879902854 4232 5411856 SGTC_2496 diffractaic acid 79.83 µM -1.11028282034696 0.146672303656628 no 2917 0.13343858685532 4231 94870 An apoptosis inducer which activates caspases. SGTC_478 N-arachidonylglycine 10 µM -1.11110023851147 0.146495651917296 no 2918 0.133262602618113 4184 5283389 SGTC_727 3032-0951 202 µM -1.11119176760076 0.146475880516567 no 2919 0.133242907011736 4239 3652836 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.11271076689801 0.146148019657635 no 2920 0.132916334922244 4066 4000243 SGTC_2989 9073649 71.4286 µM -1.11329691292029 0.146021637785178 no 2921 0.132790465927766 4158 21367202 SGTC_2975 9084847 53.72 µM -1.11366056997619 0.145943264790466 no 2922 0.132712415487816 4262 27211724 SGTC_720 r052-1644 49.9 µM -1.11689271388032 0.145247936353852 no 2923 0.132020100163809 4225 1422863 YOR257W CDC31 SGTC_2084 5306078 60.6385 µM -1.11903682373377 0.144787907517284 no 2924 0.131562214889024 4132 679340 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.11908791280104 0.144776958099504 no 2925 0.131551317952452 4149 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2545 solidagenone 89.61 µM -1.12052101801676 0.144470041947167 no 2926 0.1312459005674 4063 6708572 An anti ulcer agent SGTC_1715 st032160 10.2275 µM -1.12139466729717 0.144283155046196 no 2927 0.131059952533586 4155 5289825 SGTC_358 0075-0058 9.45 µM -1.12251121053608 0.144044546742103 no 2928 0.130822571857821 4028 1069125 SGTC_1511 0906-3109 28.5 µM -1.1245031771899 0.143619519284799 no 2929 0.130399811706204 4231 2882180 SGTC_190 3970-0790 3.722 µM -1.12660451566164 0.14317207336257 no 2930 0.12995486452844 4175 2832352 SGTC_658 3253-0951 102 µM -1.12681144619254 0.143128061849774 no 2931 0.129911105009383 4218 1184878 SGTC_2024 5144227 134 µM -1.12740504094397 0.143001862452685 no 2932 0.129785634364702 4244 3475211 SGTC_857 0438-0306 1.35 µM -1.12760482629669 0.142959404615139 no 2933 0.12974342376643 4290 4686136 SGTC_1479 0549-0158 134 µM -1.12791729911613 0.142893015827233 no 2934 0.129677423653821 4273 5440202 SGTC_270 tamoxifen 5.46 µM -1.13125223871805 0.142185763810352 no 2935 0.128974470278328 4279 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2315 7733312 200 µM -1.1315168143863 0.142129755947241 no 2936 0.128918815202419 4121 726316 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.13469912452978 0.141457264538248 no 2937 0.128250702133793 4211 688667 SGTC_1642 st009582 77.7 µM -1.13469923328158 0.14145724159353 no 2938 0.128250679342955 4218 6739311 SGTC_579 4491-1009 110 µM -1.13750303191355 0.140866527549878 no 2939 0.127664028925598 4340 1271041 SGTC_1312 1218-2183 165 µM -1.13824756094412 0.140709949185206 no 2940 0.127508561967141 4277 6744073 SGTC_1317 1273-0028 910 nM -1.13949449660456 0.140447976703305 no 2941 0.127248481200212 4231 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2292 7671323 168.05 µM -1.14060614284419 0.14021470695815 no 2942 0.127016929908639 4289 937504 SGTC_1351 1496-0003 46.5 µM -1.14206343842841 0.139909304396662 no 2943 0.126713825721352 4255 3891978 SGTC_2765 myclobutanil 7.74 µM -1.14319336225406 0.13967281987075 no 2944 0.12647915880044 4263 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1667 st014849 34.6 µM -1.14438863867015 0.139422953518714 no 2945 0.126231248916993 4298 5348460 SGTC_522 1273-0010 11.6 µM -1.14483875523524 0.139328937840578 no 2946 0.126137978983978 4310 5705015 SGTC_3118 9124250 49.47 µM -1.14859066350555 0.13854695644119 no 2947 0.125362404363188 4175 1504786 SGTC_2699 st077704 54.6 µM -1.14914941596723 0.138430756296555 no 2948 0.125247187417151 4243 645852 SGTC_1654 st012436 41.8 µM -1.15013358297878 0.138226246994161 no 2949 0.125044428169926 4240 4323132 SGTC_1107 amlodipine 47 µM -1.1513496870579 0.137973825960033 no 2950 0.124794201801534 3917 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1359 1582-0056 520 nM -1.15230581222737 0.13777558843894 no 2951 0.124597714711083 4298 3661189 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.15346746788353 0.137534999021937 no 2952 0.1243592814987 4241 390807 SGTC_970 1315-0089 19.5 µM -1.1548669468626 0.137245535327561 no 2953 0.124072458352314 4197 6811083 YLR033W RSC58 SGTC_3091 9116372 49.47 µM -1.15496961971078 0.137224315204357 no 2954 0.124051433797143 4307 17169793 SGTC_2360 9040895 200 µM -1.15826543954019 0.13654433523575 no 2955 0.123377865234703 4269 4914414 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.15906411152936 0.136379903986855 no 2956 0.123215026593433 4225 2724278 An inhibitor of dopamine biosynthesis. SGTC_3086 9117350 49.47 µM -1.16070422174846 0.136042661600016 no 2957 0.122881102203193 4184 2679265 SGTC_2324 6149169 200 µM -1.16096976367825 0.135988114136334 no 2958 0.1228270979416 4151 2888231 SGTC_169 k015-0017 16.025 µM -1.16357949162552 0.135452822078773 no 2959 0.122297233251926 4235 1840002 SGTC_734 2023-0417 80 µM -1.16532493490909 0.135095613885805 no 2960 0.121943744782475 4252 3935732 SGTC_711 k292-0785 179 µM -1.16911129950502 0.134322949500087 no 2961 0.121179395970669 4172 4146315 SGTC_2008 4012253 172 µM -1.17417363224467 0.133294653902708 no 2962 0.120162742600139 4262 603940 SGTC_1965 Pectolinarigenin 58.4 µM -1.17461444459559 0.133205370124139 no 2963 0.120074500862415 4234 5320438 An anti-inflammatory. SGTC_1501 4491-0275 38.4 µM -1.18164871175219 0.131786190164629 no 2964 0.118672558365047 4246 5104718 SGTC_937 3122-0005 46.7 µM -1.18232080237717 0.131651142327389 no 2965 0.118539217241766 4285 759535 SGTC_2659 sanguinarine 24.21 µM -1.18237716514405 0.131639821307141 no 2966 0.118528039821609 4212 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_993 3909-8757 62.7 µM -1.18357311103172 0.131399762088452 no 2967 0.11829104481044 4219 4288324 YLR208W SEC13 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.18402783548258 0.131308565747612 no 2968 0.118201022158849 4174 17037758 SGTC_443 clozapine 122 µM -1.18727922906248 0.130657762650129 no 2969 0.117558749141816 4233 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3186 9110464 49.47 µM -1.19050781180973 0.130013735412429 no 2970 0.116923430744138 4277 17018021 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.19525587540693 0.129070604519925 no 2971 0.115993536868089 4198 4330530 SGTC_3045 9092950 49.47 µM -1.19630253258299 0.128863341647721 no 2972 0.115789260411291 4260 44120432 SGTC_1288 0973-0013 65.5 µM -1.19643319176456 0.128837484257522 no 2973 0.115763777560654 4304 4315430 SGTC_2789 5281112 71.43 µM -1.19765141239156 0.128596572181182 no 2974 0.115526376030482 4288 765948 SGTC_1031 k035-0009 16 µM -1.1978069206103 0.128565841803941 no 2975 0.115496096180538 4337 5180959 SGTC_305 1682-2595 20.8 µM -1.20094750826363 0.127946312865548 no 2976 0.114885781918675 4291 226033 SGTC_1198 1612-1005 86.7 µM -1.20402885609997 0.127340488769452 no 2977 0.114289212794044 4351 6998509 SGTC_602 3130-1533 38.1 µM -1.20479052949493 0.12719104415384 no 2978 0.114142088469888 4339 720941 SGTC_2116 5511452 16.8835 µM -1.20620530237812 0.126913781662567 no 2979 0.113869169978967 4304 870744 SGTC_803 4488-1585 147 µM -1.20969448637548 0.126231782167565 no 2980 0.113198073169979 4279 747204 SGTC_605 1315-0399 119 µM -1.20986140362796 0.126199220491711 no 2981 0.113166039795085 4358 24020461 SGTC_1809 st050081 57.6 µM -1.21010628186814 0.126151461034691 no 2982 0.113119056499464 4366 5036894 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.21053893718909 0.126067109556846 no 2983 0.113036079583654 4285 688662 SGTC_1173 0443-0020 122 µM -1.21066070882966 0.126043375770018 no 2984 0.113012733412521 4284 5331295 SGTC_2582 agaric acid 100 µM -1.21074080174193 0.126027767034887 no 2985 0.112997379801814 3945 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_599 1935-0052 86.5 µM -1.21447993790707 0.125300573188614 no 2986 0.112282253138723 4288 9557311 SGTC_51 1013-0126 23.419 µM -1.21451566778115 0.125293638538373 no 2987 0.112275435275189 4318 1627850 SGTC_354 2783-3500 4.88 µM -1.21499412411695 0.125200802921396 no 2988 0.112184166228894 4306 6740761 SGTC_118 0083-0097 135.343 µM -1.21590377070435 0.125024435288603 no 2989 0.112010790762285 4281 5207356 SGTC_798 1287-0182 476 µM -1.21617841437428 0.124971219881395 no 2990 0.111958482307851 4337 1649755 SGTC_645 0845-0943 5.41 µM -1.2184626712142 0.124529231579563 no 2991 0.111524100914004 4310 1885106 SGTC_2050 5263056 171 µM -1.22109082842899 0.12402205431228 no 2992 0.111025815941007 4284 763468 YGL055W OLE1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.22213809841739 0.12382035724585 no 2993 0.110827703929212 4317 165521 SGTC_2145 5634607 200 µM -1.22275273214538 0.123702089958797 no 2994 0.110711551705518 4287 308662 SGTC_2737 bleomycin 30.5 nM -1.2237674732327 0.123507007487039 no 2995 0.110519978957588 4403 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_871 0574-0004 149 µM -1.22475125754423 0.123318082230364 no 2996 0.110334477513389 4271 9551173 SGTC_351 caspofungin 25 nM -1.2281888006731 0.122659529068461 no 2997 0.109688050926294 4306 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3218 9131285 49.47 µM -1.22883664563907 0.122535693864649 no 2998 0.109566529434067 4299 17156417 SGTC_846 0335-0850 148 µM -1.22980747167607 0.122350285275294 no 2999 0.109384604815322 4280 6819598 SGTC_167 3672-0051 66.205 µM -1.23029333267284 0.122257569392806 no 3000 0.109293640067579 4219 3237971 SGTC_2819 7996655 46.38 µM -1.23071496368939 0.122177150370447 no 3001 0.109214744755947 4265 6456960 SGTC_561 1550-0330 72.9 µM -1.23104849936164 0.122113560368589 no 3002 0.109152362780816 4257 6812934 SGTC_136 0097-0015 404.482 µM -1.23166919528468 0.121995283911055 no 3003 0.109036340705817 4302 4861337 SGTC_1286 0929-0070 131 µM -1.23352581575006 0.121641976712141 no 3004 0.10868982560592 4388 1420408 SGTC_2146 5545642 200 µM -1.2338949877236 0.121571810604549 no 3005 0.108621018750652 4269 825326 SGTC_2019 4016004 108 µM -1.23394152219551 0.121562968120493 no 3006 0.108612347806305 4344 45595336 SGTC_1500 4488-1866 171 µM -1.23488100751762 0.121384543729911 no 3007 0.108437396428132 4373 2900003 SGTC_672 1441-0018 53.7 µM -1.23716983428168 0.120950627198 no 3008 0.108012019018896 4316 251141 SGTC_582 0987-0078 156 µM -1.24004608236991 0.120406896261122 no 3009 0.107479174969886 4375 1625765 SGTC_1346 1488-2224 62.4 µM -1.24171304570346 0.120092559795806 no 3010 0.107171227452578 4324 3722427 SGTC_90 0870-0863 4.608 µM -1.24323025095688 0.119806966068342 no 3011 0.106891499119582 4343 1738164 SGTC_306 1672-3436 11.6 µM -1.24334554092818 0.119785283857132 no 3012 0.106870264570788 4347 6797378 SGTC_1201 1889-3372 45.9 µM -1.24535863101704 0.119407134418272 no 3013 0.106499976348839 4210 5392199 SGTC_41 0478-0632 82.643 µM -1.24547369822557 0.119385545066379 no 3014 0.106478838882215 4294 3750424 SGTC_933 2914-0560 114 µM -1.24582554807532 0.119319546733698 no 3015 0.106414224016793 4341 463887 SGTC_2015 5119600 184 µM -1.24620535028223 0.119248334131873 no 3016 0.106344507669415 4354 2828786 SGTC_3338 9144300 39.5675 µM -1.24756037065984 0.118994513364069 no 3017 0.106096049413449 4327 4901274 SGTC_2739 tacrine 100.86 µM -1.25051324519176 0.118442706615396 no 3018 0.105556059970645 4376 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2588 indole-3-carbinol 100 µM -1.25145848156064 0.118266452056498 no 3019 0.10538362611892 4346 3712 Induces cell cycle arrest. SGTC_194 1486-1323 56.904 µM -1.25224201883719 0.118120489537832 no 3020 0.10524084460396 4420 5178754 SGTC_1759 st043059 70 µM -1.25308959044616 0.117962741776669 no 3021 0.105086551972312 4336 669426 SGTC_1846 st056244 14.8 µM -1.25316693633346 0.11794835379111 no 3022 0.105072480019553 4354 5393182 SGTC_301 4119-0100 24.5 µM -1.25355374982256 0.11787641685776 no 3023 0.105002125429169 4361 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_853 0419-0306 21 µM -1.25405463618232 0.11778331156257 no 3024 0.104911073659328 4346 762713 SGTC_411 enrofloxacin 100 µM -1.25406763349504 0.117780896301012 no 3025 0.104908711752137 4392 71188 A bacterial gyrase inhibitor. SGTC_192 3455-0609 60.9 µM -1.25458548212894 0.117684694162932 no 3026 0.104814638203993 4394 3769639 SGTC_3180 9109287 49.47 µM -1.26023014636548 0.116639675562314 no 3027 0.103793175372315 4374 18891271 SGTC_433 pimozide 108 µM -1.2639636654424 0.115952100317538 no 3028 0.103121534332191 4257 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1935 st074532 41.6 µM -1.26461656813532 0.115832156168941 no 3029 0.103004405456472 4305 2829742 SGTC_1878 temozolomide 1 mM -1.26793011789011 0.115224785270718 no 3030 0.102411453735708 4275 5394 DNA alkylating agent. SGTC_2866 9034245 58.44 µM -1.26799591736731 0.115212747250601 no 3031 0.102399704264302 4343 6462273 SGTC_3065 9113888 49.47 µM -1.26898297962731 0.115032271420261 no 3032 0.102223567305306 4382 16648368 SGTC_485 niflumic acid 177 µM -1.27098706336779 0.114666460660632 no 3033 0.101866625470804 4379 4488 A COX2 inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM -1.27216565173912 0.114451716732364 no 3034 0.101657134426225 4292 16667744 Haematoxylin. SGTC_1353 1498-1206 8.11 µM -1.27503859261116 0.113929454312597 no 3035 0.101147791265176 4379 6756808 SGTC_477 mead ethanolamide 10 µM -1.27557037240024 0.113832970367226 no 3036 0.101053716467485 4296 16061185 SGTC_173 1273-0061 2.693 µM -1.2774617632645 0.113490276072801 no 3037 0.100719635737827 4313 2847414 YPL266W DIM1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.2798849663571 0.113052300544069 no 3038 0.100292797814216 4372 5106787 A p450 inhibitor. SGTC_2201 6605497 169.863 µM -1.28197066731474 0.112676292976854 no 3039 0.0999264680893649 4295 670741 SGTC_3278 9139605 49.47 µM -1.28211651040651 0.112650034013271 no 3040 0.0999008890071796 4335 7958859 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.2829949032249 0.112491972324288 no 3041 0.099746930857226 4367 77254 SGTC_2205 7238770 200 µM -1.286995909468 0.111774018815278 no 3042 0.0990478569473532 4415 279867 SGTC_2196 6573537 42.6665 µM -1.28741662125687 0.111698715796208 no 3043 0.0989745570287011 4369 2903087 SGTC_2593 nobiletin 86.24 µM -1.28833134138857 0.111535115689325 no 3044 0.0988153238046601 4352 72344 An anti-infammatory. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.29324600852626 0.110659049752653 no 3045 0.097962993833432 4387 6728940 SGTC_540 1187-0821 17.3 µM -1.29373287897578 0.110572531690469 no 3046 0.0978788521510345 4286 847520 SGTC_1917 st066507 28.5 µM -1.29485008640311 0.110374184523068 no 3047 0.0976859749421496 4304 3156428 SGTC_271 rotenone 740 µM -1.29627982658313 0.110120723137159 no 3048 0.0974395480759064 4395 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1403 3909-7815 62.9 µM -1.30467468612456 0.108640920850997 no 3049 0.0960018223492947 4342 6615483 SGTC_2357 9067248 200 µM -1.30890227627264 0.107901141650457 no 3050 0.0952837277377925 4322 9150235 SGTC_1787 fluconazole 80 µM -1.31099113429457 0.107536957801065 no 3051 0.0949303794553814 4087 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3324 9138759 60.749 µM -1.31281903114994 0.107218998889756 no 3052 0.0946219678044165 4404 45595710 SGTC_3303 9125618 40.5795 µM -1.31849886973892 0.10623532960031 no 3053 0.0936683515835766 4393 22695467 SGTC_527 4476-4215 268 µM -1.31853722159073 0.106228709821062 no 3054 0.0936619367095398 4386 4418754 SGTC_3021 9087658 49.47 µM -1.3193319247868 0.106091605923064 no 3055 0.0935290846747212 4378 25237042 SGTC_2861 9024595 19.48 µM -1.31995556721174 0.105984103358059 no 3056 0.0934249266892244 4300 16482810 SGTC_3236 9132701 49.47 µM -1.32011003941891 0.105957487833547 no 3057 0.093399140672492 4378 24282524 SGTC_1959 st077091 55.8 µM -1.32071768569065 0.105852837396228 no 3058 0.0932977574096517 4388 821356 YKL052C ASK1 SGTC_1051 3253-3903 78 µM -1.32276931307645 0.105500052709631 no 3059 0.0929560525904391 4376 5509239 SGTC_3040 9091894 49.47 µM -1.32293505307291 0.105471590288982 no 3060 0.0929284885292718 4244 25236966 SGTC_1950 st077106 7.18 µM -1.32391792942619 0.105302915698291 no 3061 0.092765151458355 4297 13831864 SGTC_1447 4239-0816 81.9 µM -1.32439702359957 0.105220767582849 no 3062 0.0926856112909113 4387 1341554 SGTC_2068 5226020 147 µM -1.32756648581664 0.104678482101066 no 3063 0.0921606811535104 4394 1810509 SGTC_1997 st073024 93.8 µM -1.32870816761284 0.104483640519348 no 3064 0.0919721346191485 4413 686268 SGTC_80 0159-0065 512.242 µM -1.33017086255019 0.104234398372424 no 3065 0.0917309910005486 4314 1548079 SGTC_3002 9075603 71.4286 µM -1.3342270790886 0.103545477289312 no 3066 0.0910647237414266 4339 20105405 SGTC_3219 9131112 49.47 µM -1.33598023454727 0.103248740593461 no 3067 0.0907778669110956 4257 17612988 YMR079W SEC14 SGTC_2463 5473429 200 µM -1.33833369177946 0.102851369101285 no 3068 0.0903938417918105 4381 5399405 SGTC_2407 paclitaxel 400 µM -1.34027384301636 0.102524619183925 no 3069 0.090078166064664 4447 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3168 9103419 49.47 µM -1.34344437444477 0.101992280641025 no 3070 0.0895640632036559 4432 16649256 SGTC_882 0843-0131 351 µM -1.34597831065162 0.101568276041972 no 3071 0.0891547557593111 4389 5425421 SGTC_2666 tannic acid 100 µM -1.3471536099201 0.101372049079764 no 3072 0.0889653825611372 4381 16134267 A thiamine antagonist. SGTC_2167 5876490 200 µM -1.34726660517869 0.101353198050081 no 3073 0.088947191691704 4448 686534 SGTC_3308 9128332 17.569 µM -1.34933200917101 0.101009075993909 no 3074 0.088615174342064 4382 17332805 YDL196W YDL196W SGTC_1215 3852-0577 11.2 µM -1.35017745450053 0.100868460202251 no 3075 0.0884795341031114 4432 2884876 SGTC_1958 st076513 41.9 µM -1.3508803222707 0.100751666830208 no 3076 0.0883668863044771 4338 732122 YGL099W LSG1 SGTC_2061 5245884 80.95 µM -1.35131727427727 0.100679109591555 no 3077 0.0882969104073288 4373 573863 SGTC_2000 st075254 36.4 µM -1.35244722671468 0.100491654203287 no 3078 0.0881161451043479 4294 17234175 SGTC_978 1416-0512 87.4 µM -1.35350856147782 0.100315814305509 no 3079 0.0879466083877773 4453 6814003 SGTC_1273 0849-0096 14.1 µM -1.35430833279733 0.100183458175742 no 3080 0.0878190143959803 4426 5286025 SGTC_2212 7123476 200 µM -1.35632740430208 0.0998498842993738 no 3081 0.0874975099475223 4413 1085715 SGTC_250 brefeldin a 552.239 µM -1.35759633922419 0.099640657200584 no 3082 0.0872959026071479 4303 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2638 epoxomicin 18 µM -1.35946161620573 0.0993336846457706 no 3083 0.087000178800123 4386 9915668 A protesome inhibitor. SGTC_1974 st069448 26.9 µM -1.36491758260867 0.0984397547074356 no 3084 0.0861394776763735 4394 6323587 YNR016C ACC1 SGTC_674 0498-0004 451 µM -1.36974044552061 0.0976544725703633 no 3085 0.0853839692091685 4403 4231473 SGTC_2488 5268135 45.7 µM -1.36991417755542 0.0976262706300786 no 3086 0.0853568467504818 4444 1270356 YLR208W SEC13 SGTC_1089 terbinafine 2.25 µM -1.37307106536049 0.0971148524734693 no 3087 0.0848651275726715 4422 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3095 9117207 49.47 µM -1.37572421548243 0.0966865630956334 no 3088 0.0844535159551632 4413 17015229 SGTC_3024 9090631 49.47 µM -1.38285304837792 0.0955426533138775 no 3089 0.0833549646193738 4383 25236383 SGTC_298 1391-0729 10 µM -1.38516844063953 0.0951732711632392 no 3090 0.0830004841693362 4366 3237558 SGTC_507 nimesulide 162 µM -1.39122406679355 0.0942121710966918 no 3091 0.0820787457017318 4471 4495 A COX2 inhibitor. SGTC_2751 anetholtrithion 17.25 µM -1.39271115492398 0.0939772511985976 no 3092 0.0818535770127025 4394 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2888 9058547 12.99 µM -1.39755608778484 0.0932148807808146 no 3093 0.0811232063601336 4359 16476514 SGTC_2627 acetyl isogambogic acid 100 µM -1.3985186658607 0.0930639607991931 no 3094 0.0809786857062491 4443 6857789 A caspase activator and apoptosis inducer. SGTC_2747 doxorubicin 7.63 µM -1.39892474199768 0.0930003474271716 no 3095 0.0809177760974396 4477 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1025 k007-0731 70 µM -1.39919967594247 0.0929572962303246 no 3096 0.0808765568711281 4404 6256118 SGTC_2221 6807166 181.081 µM -1.40677453366554 0.0917769566317346 no 3097 0.0797471281565049 4416 674925 SGTC_1801 st050089 28.441 µM -1.4075336075955 0.0916592900156191 no 3098 0.0796346094623441 4486 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1661 st013063 9.66 µM -1.40980582942627 0.0913077333510736 no 3099 0.0792985124308483 4506 721395 SGTC_1802 st050112 57.9 µM -1.41005877002671 0.0912686604672653 no 3100 0.079261165094061 4448 4662563 SGTC_748 act1.228 77.9 µM -1.41455166800298 0.0905766865292415 no 3101 0.0785999941048182 4423 4421505 YNR035C ARC35 SGTC_2439 5492030 7.2 µM -1.41528237929306 0.0904645151688257 no 3102 0.0784928596291932 4451 5722370 SGTC_1767 st044992 70.3 µM -1.41636794485131 0.0902980606748614 no 3103 0.0783339020366073 4494 9600693 SGTC_2354 9060492 162 µM -1.42023151376763 0.0897074881666461 no 3104 0.0777701459655098 4466 6471895 SGTC_2852 9023854 51.95 µM -1.42027934170066 0.0897001953823201 no 3105 0.0777631864589954 4459 19798528 SGTC_3116 9124943 49.47 µM -1.4204133152258 0.089679769498763 no 3106 0.0777436943088472 4416 41905195 YPL160W CDC60 SGTC_481 bay k-8644 50 µM -1.42638669407741 0.0887725663814781 no 3107 0.0768783761753358 4418 2303 A calcium channel antagonist. SGTC_2920 7982904 15.77 µM -1.42855435032094 0.088445050518882 no 3108 0.076566181355713 4451 6456808 SGTC_2113 5491891 107.031 µM -1.43025286175072 0.0881890485214323 no 3109 0.0763222292849645 4444 789979 SGTC_763 3453-1109 128 µM -1.43603901444224 0.0873210971363005 no 3110 0.0754956199691592 4494 1560353 SGTC_26 0302-0163 425.158 µM -1.437468989326 0.0871075799306078 no 3111 0.0752923890864884 4510 3100915 SGTC_1340 1486-1359 257 µM -1.4431070641584 0.0862695273143654 no 3112 0.0744951568422939 4407 4309068 SGTC_3152 9099253 49.47 µM -1.44335297835345 0.0862331119540996 no 3113 0.074460531436058 4330 25236131 SGTC_3048 9093155 49.47 µM -1.44355360364389 0.0862034115629038 no 3114 0.0744322919360172 4426 25236002 SGTC_2709 st078560 56 µM -1.44506622288337 0.0859797310175214 no 3115 0.0742196426997114 4451 17250903 SGTC_2102 5377816 72.7585 µM -1.44691963396237 0.08570624788327 no 3116 0.073959716720483 4499 1379702 SGTC_1453 4237-0541 195 µM -1.44696765764719 0.0856991703347946 no 3117 0.0739529910418471 4458 739892 SGTC_2177 5811945 192 µM -1.44980808074039 0.0852813374166503 no 3118 0.0735560227442521 4475 5343475 SGTC_2663 amphotericin b 100 µM -1.45063314319277 0.0851602553058279 no 3119 0.0734410206119766 4495 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3164 9100705 49.47 µM -1.45209483298629 0.0849460612379519 no 3120 0.073237619227432 4484 17174235 SGTC_2192 5915882 198.485 µM -1.45342954013326 0.0847508280182088 no 3121 0.073052264813179 4442 2876149 SGTC_2097 5376186 200 µM -1.45350520320403 0.0847397705493712 no 3122 0.0730417680391811 4441 742755 SGTC_766 1391-0721 126 µM -1.45459105344748 0.0845812025720942 no 3123 0.0728912546363775 4486 1020919 YIL115C NUP159 SGTC_816 0325-0417 81.3 µM -1.45721660266939 0.0841987104099439 no 3124 0.0725282995162338 4497 68101 SGTC_1673 st016611 27.3 µM -1.46005929759417 0.0837860496896638 no 3125 0.0721368888484348 4469 5226799 SGTC_1967 st070177 51.4 µM -1.46444007812475 0.0831530894229306 no 3126 0.0715368721455814 4474 5729214 SGTC_930 2810-3379 265 µM -1.46518087258696 0.0830464115556919 no 3127 0.0714357883495514 4475 1015764 SGTC_3251 9135047 49.47 µM -1.46827959805584 0.0826012961911943 no 3128 0.0710141452153694 4520 17682963 SGTC_2909 7941780 10.49 µM -1.47193897830072 0.0820779610174855 no 3129 0.0705186783228767 4436 1243215 SGTC_739 1486-1183 203 µM -1.47213039254772 0.0820506553952262 no 3130 0.0704928348434387 4472 4346692 SGTC_3351 9150312 21.596 µM -1.47220880723922 0.0820394713601748 no 3131 0.0704822499154337 4399 4904905 SGTC_2341 7987486 176.74 µM -1.47234612986119 0.0820198882435711 no 3132 0.0704637161531369 4494 1258686 SGTC_2248 tofa 1.1 µM -1.48278838121262 0.0805410487114174 no 3133 0.0690653219912619 4505 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1531 st059297 52.4 µM -1.48468394409576 0.0802747712282818 no 3134 0.0688137834418292 4527 7566702 SGTC_1820 st053765 18.6 µM -1.49001292393878 0.0795297520746124 no 3135 0.0681104188931452 4508 3690829 SGTC_1666 st014829 29 µM -1.49176851097713 0.0792854611409035 no 3136 0.0678799207900516 4490 3858230 SGTC_2619 obliquin 87.91 µM -1.49232436967936 0.0792082316125445 no 3137 0.0678070655600237 4464 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3183 9108214 49.47 µM -1.49237042687 0.079201835105156 no 3138 0.0678010316514581 4482 4974831 SGTC_2605 digitonin 300 nM -1.49263491781789 0.0791651096873691 no 3139 0.0677663889736675 4494 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_18 0111-0177 500 nM -1.49423122512431 0.0789437309996129 no 3140 0.0675575969331195 4571 721752 SGTC_2886 9058944 51.95 µM -1.49630093851307 0.0786573980875664 no 3141 0.0672876253308216 4446 4949929 SGTC_3297 9117502 71.43 µM -1.5047650695357 0.0774946208524697 no 3142 0.0661922436058721 4522 7453720 SGTC_206 4546-0025 72.014 µM -1.50572651373941 0.0773633704314765 no 3143 0.0660686973531639 4531 6620745 YIL048W NEO1 SGTC_3179 9107801 49.47 µM -1.5064041239019 0.0772709687637283 no 3144 0.0659817313512415 4482 4818259 SGTC_3284 9108171 64.8615 µM -1.51157087820441 0.0765691641344504 no 3145 0.0653215324045631 4478 8687505 SGTC_3354 9151612 71.43 µM -1.51616243444507 0.0759495672365423 no 3146 0.0647391421457378 4491 27261949 SGTC_3114 9122766 49.47 µM -1.51638648664335 0.0759194310109456 no 3147 0.064710827012577 4496 17176985 SGTC_828 2074-0507 139 µM -1.52580207637241 0.0746611985842006 no 3148 0.0635295817252706 4548 X828 SGTC_3090 9117696 49.47 µM -1.52701636519649 0.0745000950061897 no 3149 0.0633784709999629 4469 7923821 SGTC_518 1021-0119 62.6 µM -1.53114206722048 0.0739547070941465 no 3150 0.0628671424886122 4483 1097762 SGTC_1238 0333-0287 48.8 µM -1.53762620052729 0.073103723921193 no 3151 0.0620700187308756 4510 7226 SGTC_694 1315-0438 43.2 µM -1.5403561463124 0.0727476931304181 no 3152 0.0617367823785826 4545 6793154 SGTC_1287 0971-0001 34.6 µM -1.54352190462321 0.0723364893372054 no 3153 0.0613520984772807 4506 4665869 SGTC_1613 st002381 52.1 µM -1.54475408404028 0.0721769225873759 no 3154 0.0612028786983069 4514 551167 SGTC_2380 9035439 200 µM -1.54736374596559 0.0718398633326868 no 3155 0.0608877791112099 4568 6462575 SGTC_442 cape 100 µM -1.56586401406761 0.069484916970316 no 3156 0.0586902280236972 4558 5281787 SGTC_3177 9107506 49.47 µM -1.5708749698677 0.0688574044066469 no 3157 0.0581058468195279 4506 8897194 SGTC_2400 5203494 178.7 µM -1.5718880918856 0.0687310656392179 no 3158 0.0579882533478637 4425 6777674 SGTC_284 0988-0104 32.6 µM -1.57440563195341 0.0684178962890142 no 3159 0.0576968513144395 4516 4666532 SGTC_2556 citropten 84.59 µM -1.57565732603096 0.0682626021477631 no 3160 0.0575523985364308 4523 2775 A potential DNA crosslinker. SGTC_613 3914-0030 117 µM -1.57714880593077 0.068077913809287 no 3161 0.0573806446741606 4265 1145395 SGTC_575 k072-0246 11.9 µM -1.5804645422767 0.0676687120166453 no 3162 0.0570002604352503 4618 6796779 SGTC_269 exalamide 29 µM -1.58078143795272 0.0676297029696278 no 3163 0.0569640100656686 4512 3316 A derivative of salicylamide. SGTC_1521 st012942 49.4 µM -1.58215729314453 0.0674605401532382 no 3164 0.0568068335177575 4452 24207259 SGTC_1247 0448-0043 5.84 µM -1.58250742560718 0.0674175432469722 no 3165 0.0567668892500869 4520 3089013 YGL099W LSG1 SGTC_3246 9135460 32.98 µM -1.58359507160893 0.067284113415778 no 3166 0.0566429480919783 4520 41446951 SGTC_1249 0481-0015 10.2 µM -1.58727535021008 0.0668341393435013 no 3167 0.0562251477564784 4486 4227577 SGTC_1223 0764-0573 147 µM -1.59172750202401 0.0662929071815905 no 3168 0.0557229730160082 4539 1609797 SGTC_3119 9125183 49.47 µM -1.59186606789995 0.0662761168503664 no 3169 0.0557074006362477 4424 22695334 SGTC_578 3460-0051 92 µM -1.59229863224772 0.0662237232666412 no 3170 0.0556588100666767 4582 2876744 SGTC_2518 prenyletin 46.28 µM -1.59640070824027 0.0657284599623621 no 3171 0.0551996790647512 4565 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1169 aniline yellow 25.8 µM -1.60437397348885 0.0647740290512022 no 3172 0.0543158221731509 4497 6051 A DNA damaging agent. SGTC_3096 9117468 49.47 µM -1.60478969790451 0.0647245619657056 no 3173 0.054270046965687 4515 41316311 SGTC_2669 eugenol 100 µM -1.61040267497337 0.0640595418199569 no 3174 0.0536549885015792 4576 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_767 0929-0023 86 µM -1.61260539945751 0.0638000212628622 no 3175 0.0534151323359745 4578 1204563 SGTC_2662 daunorubicin 22.37 µM -1.61312460170638 0.0637389691631154 no 3176 0.0533587199791851 4438 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2602 kawain 100 µM -1.61511550038769 0.063505283995657 no 3177 0.0531428424231464 4514 5369129 SGTC_1188 1403-0014 4.57 µM -1.61669319649747 0.0633205731828677 no 3178 0.0529722616195674 4582 9614867 SGTC_867 0518-0118 155 µM -1.62562889520449 0.0622822966079337 no 3179 0.0520143122382517 4537 6848158 SGTC_2932 9016711 44.54 µM -1.63448262695545 0.0612666880095216 no 3180 0.0510787756059957 4542 7117328 SGTC_2502 avocadyne acetate 18.59 µM -1.63745186405974 0.0609290004923821 no 3181 0.0507680444773953 4504 3952079 SGTC_1222 0366-0074 1.18 µM -1.63861193526713 0.0607974630870808 no 3182 0.0506470525319379 4569 286520 SGTC_2693 st077581 40.7 µM -1.6389102905423 0.0607636692977521 no 3183 0.0506159721300735 4515 25238761 SGTC_864 0469-0573 172 µM -1.64575550053153 0.0599923611230902 no 3184 0.0499070536610572 4546 689425 SGTC_1234 0326-0494 15.5 µM -1.64704691441709 0.0598477099553237 no 3185 0.0497742016180828 4611 1547813 SGTC_3204 9114183 49.47 µM -1.65352158352417 0.0591265973849918 no 3186 0.0491123785787202 4517 17027248 SGTC_3039 9090270 49.47 µM -1.66213145267804 0.0581782556835812 no 3187 0.0482432101849022 4571 17173750 SGTC_1053 3366-3204 134 µM -1.67813319267654 0.0564475148950031 no 3188 0.046660550090397 4574 3632071 YPR165W RHO1 SGTC_1001 4048-4355 44.4 µM -1.67840971194242 0.0564179673243014 no 3189 0.0466335714775598 4576 21824233 SGTC_977 1348-1378 135 µM -1.679770191442 0.0562727702644237 no 3190 0.046501018477754 4564 X977 SGTC_3049 9092223 49.47 µM -1.68160522564643 0.0560773932352113 no 3191 0.0463227083123228 4554 8623917 SGTC_2262 9014885 67.46 µM -1.68348294717296 0.0558780254438264 no 3192 0.0461408189139205 4627 6457424 SGTC_904 1141-0088 396 µM -1.68995113460313 0.0551955412423031 no 3193 0.045518651821869 4596 1378119 SGTC_1902 st060212 70.5 µM -1.69050451529378 0.0551374589401567 no 3194 0.0454657375752488 4576 688944 SGTC_1739 st037196 92.5 µM -1.69176578094136 0.0550052581532132 no 3195 0.0453453202375317 4577 612214 SGTC_631 k072-0230 41.5 µM -1.69721243727653 0.0544372355171937 no 3196 0.0448282522900582 4579 5773147 SGTC_3142 9086498 49.47 µM -1.69755280241894 0.0544018940138034 no 3197 0.0447960986203855 4452 25236367 SGTC_911 3456-4043 236 µM -1.69811247588321 0.0543438202928355 no 3198 0.0447432676715997 4565 914281 SGTC_885 0865-0106 16.8 µM -1.7058534098083 0.0535456135374997 no 3199 0.0440176880198461 4554 2793380 SGTC_406 estrone 100 µM -1.71284552817463 0.0528326315407522 no 3200 0.0433704808627592 4586 5870 A steroid. SGTC_2298 7976326 193.81 µM -1.71336207441309 0.0527802598121985 no 3201 0.0433229744846258 4566 2235818 SGTC_2056 5235370 200 µM -1.71355983518276 0.0527602200965054 no 3202 0.0433047976981003 4514 5511916 SGTC_2237 6667747 47.222 µM -1.71595354430586 0.0525181365425265 no 3203 0.0430852727129036 4593 729940 YDL015C TSC13 SGTC_855 0428-0020 25 µM -1.71802819532506 0.0523090343414718 no 3204 0.042895736286911 4618 6812414 SGTC_1137 ixabepilone 100 µM -1.72121683467796 0.0519889437077124 no 3205 0.0426057420446521 4552 154225 A novel microtubule stabilizer. SGTC_1064 honokiol 6.76 µM -1.72226037416745 0.0518845269458283 no 3206 0.042511181225722 4602 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_335 4077-0256 27.6 µM -1.74233078373361 0.0499085209381378 no 3207 0.0407252899022909 4526 3121989 SGTC_1135 dihydrocapsaicin 536.708 nM -1.74784605206576 0.049376167492979 no 3208 0.040245344260403 4524 107982 A Capsaicinoid. SGTC_1981 st071826 47 µM -1.75502595252914 0.0486899408885911 no 3209 0.039627434349512 4642 11838600 SGTC_3176 9106582 49.47 µM -1.75768200559429 0.0484380258276136 no 3210 0.0394008156381806 4638 17018027 SGTC_2576 guaiol 23.12 µM -1.77130889814803 0.0471619238985197 no 3211 0.0382546742881928 4527 227829 SGTC_712 r015-0009 80.6 µM -1.77827221522211 0.0465203207533199 no 3212 0.0376795786920817 4655 6813872 YLR060W FRS1 SGTC_2524 avocatin b 10.57 µM -1.78069977280554 0.0462982983364702 no 3213 0.0374807551479395 4647 6710748 SGTC_119 0121-0043 24.815 µM -1.78144932955298 0.0462299166618544 no 3214 0.037419537821107 4620 1092378 SGTC_1186 1319-0216 26 µM -1.78362142500768 0.0460322154786726 no 3215 0.0372426008918589 4652 4565136 SGTC_2384 9036245 200 µM -1.7983304264664 0.0447112328115844 no 3216 0.0360623304093707 4604 6462766 SGTC_2390 9097792 176.6 µM -1.80197647412319 0.0443885558558361 no 3217 0.0357745535138284 4639 4497149 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.80583558006748 0.0440490700849898 no 3218 0.0354720129985829 4653 688788 SGTC_2898 9056270 58.44 µM -1.80976579198931 0.0437054840565538 no 3219 0.0351660574290133 4646 19154699 SGTC_3093 9117344 49.47 µM -1.81004227667902 0.0436813949188544 no 3220 0.0351446156648844 4640 24824913 SGTC_3350 9150499 3.57 µM -1.81608431136485 0.0431576437324515 no 3221 0.0346787199624886 4629 4910996 YPR165W RHO1 SGTC_74 000s-0487 160.283 µM -1.82747422882941 0.042184112860043 no 3222 0.0338142487916097 4521 677548 SGTC_3089 9117425 49.47 µM -1.83000450525982 0.0419702729928615 no 3223 0.0336246325795789 4604 9401657 SGTC_762 1165-0429 115 µM -1.83981677283166 0.0411493003691878 no 3224 0.0328975710490229 4650 5967793 SGTC_1638 st008370 60.6 µM -1.84082071277895 0.0410660421093381 no 3225 0.0328239182229034 4600 24207134 SGTC_1324 1418-0026 34.4 µM -1.84286948912499 0.0408965578469619 no 3226 0.0326740339942971 4656 1372513 SGTC_3334 9142812 21.919 µM -1.84918499115589 0.0403776780159618 no 3227 0.0322155525995053 4632 45283678 SGTC_813 k007-0158 173 µM -1.85191877142237 0.0401547354566288 no 3228 0.0320187439897403 4638 6523916 SGTC_3238 9133470 49.47 µM -1.85871819407663 0.0396045703245391 no 3229 0.0315335465895393 4655 3534688 SGTC_2118 5526350 200 µM -1.86064150345762 0.0394500657523031 no 3230 0.0313974098398522 4637 743594 SGTC_1372 2752-0194 270 µM -1.86211724170758 0.039331848516288 no 3231 0.0312932831053618 4582 823334 SGTC_1977 st070720 65.3 µM -1.86794117385461 0.0388681201904593 no 3232 0.030885135480092 4657 682188 SGTC_747 3448-8087 38.7 µM -1.88898292757343 0.0372296545078712 no 3233 0.029447058182318 4684 5168703 SGTC_858 0438-0351 2.77 µM -1.89141465126639 0.0370439949488213 no 3234 0.0292845071508145 4648 2799119 SGTC_576 1073-0113 22.7 µM -1.90163471759687 0.0362719601859772 no 3235 0.0286094629422765 4696 5439563 SGTC_2142 5622915 118.518 µM -1.90554015627529 0.0359804393268933 no 3236 0.0283549463669829 4667 5322196 SGTC_2949 9072542 2.23 µM -1.91002182111081 0.0356482738291756 no 3237 0.0280652018968999 4616 16457352 SGTC_2899 9053889 58.44 µM -1.91586369237353 0.035219072287804 no 3238 0.0276912239989673 4667 6470052 SGTC_1695 st026914 34.495 µM -1.91836591455393 0.0350365356170909 no 3239 0.027532314942273 4667 3289191 SGTC_601 0986-0029 62.9 µM -1.93526323523112 0.0338241064449499 no 3240 0.0264790007113272 4631 24747981 SGTC_1689 st020265 53.493 µM -1.93633143554029 0.0337486347198799 no 3241 0.0264135605280548 4657 5758320 YPR016C TIF6 SGTC_1438 4092-1045 4 µM -1.93807057304083 0.0336260556381763 no 3242 0.0263073065201907 4700 1351342 SGTC_1835 st008666 49.2 µM -1.93983128204703 0.0335023296445047 no 3243 0.0262000987933389 4651 690455 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.94220917794659 0.0333358286714723 no 3244 0.0260558912331422 4627 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1219 1469-0211 33.1 µM -1.9651191132472 0.0317663187468948 no 3245 0.0247002264601722 4682 6822282 SGTC_2045 5106652 78.05 µM -1.96612034290759 0.0316991432647833 no 3246 0.0246423555228398 4671 673349 SGTC_3327 9140648 26.9345 µM -1.96844979970939 0.0315433072162708 no 3247 0.0245081533752977 4687 8029710 SGTC_1050 3232-1156 69.3 µM -1.97390215903558 0.0311810297312524 no 3248 0.0241964346162228 4651 700529 SGTC_221 trifluoperazine 10.304 µM -1.98011376586112 0.0307725057215135 no 3249 0.0238453733378375 4668 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1912 st060209 90.8 µM -1.98036144989021 0.0307563083823335 no 3250 0.0238314642164474 4648 688787 SGTC_157 1348-1695 65.819 µM -1.98179860669222 0.0306624645127967 no 3251 0.0237508927415848 4605 5380510 SGTC_1971 st069429 63.5 µM -1.98390170041769 0.0305255635865024 no 3252 0.0236333996680068 4679 1246522 YGL099W LSG1 SGTC_3336 9143619 71.43 µM -1.99153835451251 0.0300327058902908 no 3253 0.0232108664677004 4677 45595730 SGTC_2176 5809774 33.9695 µM -2.00180194922188 0.0293807201644789 no 3254 0.022653018119982 4627 2870539 SGTC_884 0851-0618 334 µM -2.00704847205709 0.0290520054320674 no 3255 0.0223722510103383 4705 9642473 SGTC_1737 st035557 69.7 µM -2.00745337898045 0.0290267639916212 no 3256 0.0223507050020252 4565 5716916 SGTC_1300 1094-0077 113 µM -2.00816082559504 0.0289827063048439 no 3257 0.0223131021830522 4687 5532636 SGTC_1685 st024049 53.0905 µM -2.00864166084088 0.0289527930392201 no 3258 0.0222875748846194 4714 1941139 SGTC_2367 9070478 135.38 µM -2.00873907072665 0.0289467361946178 no 3259 0.0222824064457819 4632 572802 SGTC_2935 9038016 29.96 µM -2.01276856762826 0.0286971075678154 no 3260 0.0220694910521619 4639 6463195 SGTC_3124 9127567 49.47 µM -2.01627378454627 0.0284814166145086 no 3261 0.0218856773174146 4664 17592030 SGTC_117 lucigenin 22.078 µM -2.02701410572591 0.0278289008662213 no 3262 0.0213304850638988 4640 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3344 9148862 3.898 µM -2.03526284097548 0.0273362561623664 no 3263 0.0209122164917304 4703 4905352 SGTC_3133 9127736 49.47 µM -2.04036758429409 0.0270350414534491 no 3264 0.0206568639981482 4681 27243420 SGTC_1162 k048-0130 20.1 µM -2.05153076165196 0.0263859817084046 no 3265 0.0201076435506122 4700 6797406 SGTC_2070 5230947 200 µM -2.05544886183166 0.0261612819132237 no 3266 0.0199178350849546 4743 2835538 SGTC_2352 9027995 87.8 µM -2.06041898897152 0.0258785535697183 no 3267 0.0196792515557959 4670 2997347 SGTC_246 cycloheximide 667 µM -2.06714517020188 0.0255000062575839 no 3268 0.0193602384419308 4687 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3178 9107506 49.47 µM -2.08363818661789 0.0245913708441753 no 3269 0.0185965453745547 4675 8897194 SGTC_2946 9065502 71.43 µM -2.08985493368594 0.0242560017357053 no 3270 0.0183154164599359 4632 16489101 SGTC_502 l-744,832 89.3 µM -2.0931458981547 0.0240800274498809 no 3271 0.0181680662775372 4713 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1242 0402-0103 60.1 µM -2.09924889680212 0.0237565267067633 no 3272 0.0178974828472966 4649 432868 SGTC_863 0466-0191 129 µM -2.11547685225603 0.0229140642095896 no 3273 0.0171946628850079 4734 765160 YPR165W RHO1 SGTC_10 0279-0212 42.575 µM -2.12402193965436 0.0224806612754934 no 3274 0.0168341545173646 4736 39851 YBR002C RER2 SGTC_1338 1486-1223 76 µM -2.12985162678142 0.022188965854393 no 3275 0.0165919324282971 4710 3444526 SGTC_2130 NSC 7 2.4545 µM -2.13766465309571 0.0218030457424731 no 3276 0.0162719851382429 4720 21448 SGTC_1503 4585-0012 61.3 µM -2.14044708813909 0.0216669849070547 no 3277 0.016159326274289 4729 2922052 SGTC_1945 st075991 56.6 µM -2.15035981577093 0.0211880696778303 no 3278 0.015763382165747 4702 1084980 SGTC_3128 9127691 49.47 µM -2.16372911215221 0.0205563636704499 no 3279 0.0152425726808542 4708 41316314 SGTC_1254 0550-0035 264 µM -2.18083385082144 0.0197714860440768 no 3280 0.014597853913816 4700 15121435 SGTC_2263 7948595 193.29 µM -2.18993928312267 0.0193641454627733 no 3281 0.0142643202645006 4735 2971371 SGTC_2479 5617353 43.85 µM -2.19223052814263 0.0192627745687578 no 3282 0.014181432588339 4709 2731746 SGTC_900 1112-0045 141 µM -2.19297875925434 0.01922976863849 no 3283 0.014154454745407 4685 56211 YIL048W NEO1 SGTC_383 2324-0395 7.37 µM -2.23328191258633 0.0175215767999396 no 3284 0.0127651797624531 4716 3146421 SGTC_2401 5128683 200 µM -2.2694809789345 0.0160994558547195 no 3285 0.0116195463212555 4708 708373 SGTC_629 3448-6466 76.7 µM -2.28137329616825 0.0156543719836039 no 3286 0.0112631834136859 4751 573744 SGTC_120 rhodamine 6G 52.259 µM -2.31399102603393 0.0144874242806041 no 3287 0.0103341071992542 4727 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2288 7946289 167.31 µM -2.31728057645786 0.0143740029572185 no 3288 0.0102442263373503 4715 1246052 SGTC_1260 0700-1617 7.75 µM -2.32429621869326 0.0141346605149939 no 3289 0.0100548116719466 4716 2853078 SGTC_1468 k284-1086 134 µM -2.33591870482023 0.0137457083536564 no 3290 0.00974773945161794 4730 15996457 SGTC_2634 4'-methoxyflavone 100 µM -2.34262561229043 0.0135254870091221 no 3291 0.00957429351037476 4705 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1843 st055809 45.5 µM -2.36009730329425 0.012966051139096 no 3292 0.00913507110209484 4754 16413835 SGTC_164 4100-3994 89.624 µM -2.36804682984644 0.0127182059296252 no 3293 0.00894113614416954 4711 4615967 SGTC_3129 9127257 49.47 µM -2.39339054844779 0.0119552274316246 no 3294 0.00834673059116811 4706 837894 SGTC_2186 6124449 200 µM -2.40171344830928 0.0117134780928813 no 3295 0.00815924286306376 4763 3834182 YLR033W RSC58 SGTC_2555 cholic acid 100 µM -2.40830680360981 0.0115249887207946 no 3296 0.00801335315272193 4731 6708657 Influences liver metabolism. SGTC_2035 5154463 94.595 µM -2.4085314896109 0.0115186121297024 no 3297 0.0080084222407219 4765 2769623 SGTC_252 miconazole 1.30953 nM -2.41125775271529 0.0114414845698526 no 3298 0.00794880444965597 4694 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_946 3434-1334 87.4 µM -2.41212023006391 0.0114171781854426 no 3299 0.00793002527346423 4727 4047976 SGTC_1729 st035615 45.989 µM -2.43210400751214 0.0108664218183651 no 3300 0.00750569802055024 4729 17385451 SGTC_1837 st055472 66.5 µM -2.45027312543147 0.0103858947403394 no 3301 0.00713739446173295 4767 676091 SGTC_1636 st007707 68.9 µM -2.47378952927778 0.00979151967087452 no 3302 0.00668442149080955 4760 403051 SGTC_390 dec-rvkr-cmk 16.7 µM -2.48482338428228 0.0095230326495404 no 3303 0.00648078614467923 4762 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_307 1501-1223 22.3 µM -2.48914077077297 0.00941974277058545 no 3304 0.00640261261571003 4770 2830329 SGTC_2296 7971656 126.45 µM -2.50415234102059 0.00906819118553681 no 3305 0.00613725852560973 4743 666570 SGTC_2175 5807670 165.306 µM -2.51484229084113 0.00882490163238431 no 3306 0.00595428204719491 4751 241186 SGTC_1004 4084-0029 199 µM -2.5220657838262 0.00866376088015389 no 3307 0.00583339439488575 4761 716894 YLR208W SEC13 SGTC_1750 st081859 2.357 µM -2.5398208970618 0.00827860249209544 no 3308 0.00554546243674487 4707 5291695 SGTC_1158 4092-0494 91.8 µM -2.55457448030653 0.00797007921552613 no 3309 0.00531588406216798 4788 1148199 SGTC_988 1497-1057 103 µM -2.56468326219287 0.00776456699603712 no 3310 0.00516350138893217 4769 3533044 SGTC_1944 st076371 56.9 µM -2.57219925094797 0.00761480330094103 no 3311 0.00505273567774499 4753 24208455 SGTC_3139 9095020 49.47 µM -2.57511435875725 0.00755740495528432 no 3312 0.00501034744195931 4728 25236292 SGTC_2396 5342950 42.78 µM -2.581442735407 0.0074341093118024 no 3313 0.00491941564093002 4751 1886677 SGTC_183 3914-0051 30.55 µM -2.58787701545656 0.00731057091601914 no 3314 0.00482847262033674 4758 1596232 SGTC_1449 4112-4002 201 µM -2.59296850891354 0.00721410037471704 no 3315 0.00475757413515294 4787 2059539 SGTC_2859 9028643 45.46 µM -2.61266946762489 0.00685131346786378 no 3316 0.00449190701763342 4687 17151580 SGTC_3144 9087057 49.47 µM -2.63002607554742 0.00654514804336485 no 3317 0.00426891596070056 4724 17249618 SGTC_2770 toltrazuril 17.5 µM -2.65128594978337 0.00618666151685518 no 3318 0.00400929607127836 4742 68591 Kills coccidiodes. SGTC_717 1532-0246 73.2 µM -2.66704610947779 0.00593224855368506 no 3319 0.00382605862966089 4775 9561992 SGTC_2848 9016370 25.97 µM -2.67403645168597 0.00582240628855943 no 3320 0.00374721524780936 4733 7894410 SGTC_1533 dihydroergotamine mesylate 29.4 µM -2.74191651862888 0.00484608587730461 no 3321 0.00305409317374157 4799 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1152 3909-8331 15.9 µM -2.81981963398027 0.00390760756231335 no 3322 0.00240253247341294 4788 16001939 SGTC_3323 9138564 53.9225 µM -2.82243559086552 0.00387913387329611 no 3323 0.00238301972182466 4787 43912313 YNL103W MET4 SGTC_973 1325-0077 65.9 µM -2.84977140750101 0.00359252907215572 no 3324 0.00218753302968827 4796 2835149 SGTC_142 0335-0849 62.6745 µM -2.90741227140173 0.00304961149138784 no 3325 0.0018221627443264 4757 3889043 YPR107C YTH1 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -2.91782567230249 0.00295981153999565 no 3326 0.00176240675386717 4800 688801 SGTC_2775 cyproheptadine 69.59 µM -2.94884552365476 0.00270626026274255 no 3327 0.00159481682476082 4786 2913 A selective serotonin reuptake inhibitor. SGTC_381 3461-2219 42.7 µM -2.95377366865945 0.00266783488676976 no 3328 0.00156957069083051 4784 2883159 SGTC_1164 k060-0068 93.7 µM -2.9615578410041 0.0026081436924056 no 3329 0.00153043497753922 4791 5963676 SGTC_2614 arthonioic acid 13.39 µM -2.99184910827188 0.00238717558237276 no 3330 0.00138646642113003 4732 6710684 SGTC_1136 pergolide 1.05886 µM -3.03405580385508 0.00210751086190086 no 3331 0.00120644896582864 4768 47811 A dopamine receptor agonist. SGTC_1257 0669-0121 16 µM -3.09945934088822 0.00173245185463232 no 3332 0.000969370929592283 4777 4307855 SGTC_952 1185-0122 232 µM -3.25194689390785 0.00108218210718269 no 3333 0.000573087174960362 4777 678600 SGTC_2544 sphondin 68.51 µM -3.26435297314132 0.00104065767046347 no 3334 0.00054857194569569 4782 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2032 5185112 25.99 µM -3.29599554192137 0.000941277134937043 yes 3335 0.000490367857540812 4797 5718189 SGTC_127 0180-0333 59.125 µM -3.34320391675627 0.000809125320377413 yes 3336 0.000414085093039717 4789 771601 SGTC_2543 pimpinellin 60.67 µM -3.3437667559009 0.000807658257330078 yes 3337 0.000413245964702573 4776 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -3.34549376206529 0.000803172013617666 yes 3338 0.000410681033656548 4782 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2172 5754775 163.918 µM -3.42173305895356 0.000626540101829807 yes 3339 0.000311116857170715 4800 2263357 SGTC_2444 5485484 36.41 µM -3.45240084100134 0.000566201934399545 yes 3340 0.000277810826040622 4800 6790631 SGTC_2027 5150920 200 µM -3.45687586730675 0.000557860782561962 yes 3341 0.000273238257821277 4795 786715 SGTC_633 0437-0093 97.7 µM -3.46096333802639 0.000550341437011612 yes 3342 0.000269123054090103 4795 2831118 SGTC_2406 ethylparaben 405.7 µM -3.53111659974594 0.000435051315331515 yes 3343 0.000206904644542512 4775 8434 A possible steroid mimic. SGTC_2805 7950783 58.44 µM -3.54318589420876 0.000417635379271344 yes 3344 0.000197661966080339 4793 1178958 YDL195W SEC31 SGTC_2025 5147754 141 µM -3.97850373516249 8.8210761781053e-05 yes 3345 3.46751610300649e-05 4806 315777 YLR208W SEC13 SGTC_379 3970-0972 5.9 µM -4.21943919499241 3.48405596667531e-05 yes 3346 1.22455381521841e-05 4808 2898042 YBL034C STU1 SGTC_910 3454-3003 490 µM -5.13223547656906 6.60524437550776e-07 yes 3347 1.4316048429761e-07 4802 820824