SGTCid condition conc unit YEL023C|YEL023C.score YEL023C|YEL023C.strain.pval YEL023C|YEL023C.strain.significant YEL023C|YEL023C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_6 0844-0013 19.835 µM 6.68372968474035 8.7605089858992e-12 yes 1 1.16468152738404e-11 9 1584900
SGTC_1937 st074714 47.2 µM 5.0550093677543 1.86456633098499e-07 yes 2 2.15184821855972e-07 19 17250970
SGTC_632 0781-2353 4.65 µM 5.05327063527087 1.88186602235125e-07 yes 3 2.17153900872324e-07 18 6811515 YHR007C ERG11
SGTC_1375 2910-0797 186 µM 5.04678637699612 1.94775807481904e-07 yes 4 2.24651616791616e-07 11 742508
SGTC_1926 methyl fluorone black 53.6 µM 4.3499890885743 6.18180473147844e-06 yes 5 6.80721531337915e-06 50 72721 Reacts with homocysteine.
SGTC_1690 st023502 41.2 µM 4.19791356305296 1.23423186530101e-05 yes 6 1.34692703412418e-05 6 24207482
SGTC_626 0214-0009 33 µM 4.08765957774707 2.00900692079085e-05 yes 7 2.17873466603824e-05 14 3437874
SGTC_3008 9078912 71.4286 µM 3.92963892728936 3.95629017390762e-05 yes 8 4.25367564720274e-05 19 16648731
SGTC_3299 9121982 43.1275 µM 3.83512076956638 5.86541517536412e-05 yes 9 6.27513058547619e-05 36 17594604 YPL160W CDC60
SGTC_2383 9036125 200 µM 3.47301903323638 0.000244782946121914 yes 10 0.000257319428721314 12 79580
SGTC_2786 7743617 45.45 µM 3.40825072796188 0.000311883165853775 yes 11 0.000326903949963519 49 583674
SGTC_2136 5328288 199.296 µM 3.40742886053208 0.000312835314274387 yes 12 0.000327890002974966 34 262395
SGTC_1164 k060-0068 93.7 µM 3.35130768318039 0.000384635801602985 yes 13 0.000402154416829283 52 5963676
SGTC_1195 1502-0147 41.1 µM 3.2997274292158 0.000463841233490378 yes 14 0.000483893875571493 50 817940
SGTC_1353 1498-1206 8.11 µM 3.26509513067963 0.000525230822459046 yes 15 0.000547136591482366 90 6756808
SGTC_13 0199-0087 65 µM 3.26293307950694 0.000529302172206013 yes 16 0.00055132777004814 25 4589825
SGTC_1376 2910-0861 41.3 µM 3.26044112746423 0.000534030968153961 yes 17 0.000556195288336107 46 1112859
SGTC_618 k072-0232 33.2 µM 3.20707529721284 0.000645166021328253 yes 18 0.000670459465942072 29 5872756 YGL099W LSG1
SGTC_429 1112-0049 25.5 µM 3.11038291382415 0.000902477637073075 yes 19 0.000934224775089739 72 2836170
SGTC_2681 menadione 3.18 µM 3.08576895246879 0.0009815810661101 yes 20 0.00101513258433013 52 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2132 5317594 122.667 µM 3.02279137962115 0.0012138167803491 no 21 0.00125227418987126 57 794577
SGTC_3304 9125678 46.087 µM 2.99774108715164 0.00131942357458113 no 22 0.00135994318065279 101 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_795 0685-0265 78 µM 2.98308469405701 0.00138504128243146 no 23 0.00142679508794417 67 302754
SGTC_1372 2752-0194 270 µM 2.98274293726672 0.00138660630948943 no 24 0.00142838913074941 49 823334
SGTC_1163 k060-0048 49.9 µM 2.95106084419983 0.0015389048807653 no 25 0.0015834226352239 73 6809982
SGTC_877 0771-0151 33.1 µM 2.94160491229774 0.00158723045986753 no 26 0.00163258109266105 45 6166523
SGTC_22 0964-0034 14.468 µM 2.93659964201802 0.00161336655155353 no 27 0.00165916098584396 94 138402
SGTC_2511 berberine 10.47 µM 2.85986571007221 0.00206628110989241 no 28 0.0021191021785751 65 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2083 5306046 65.942 µM 2.84002753866905 0.00220078887055846 no 29 0.00225548197033971 94 539837
SGTC_1036 k216-0215 33.5 µM 2.8368653475241 0.00222294800599375 no 30 0.00227794106789422 125 622330
SGTC_783 0848-0141 92.7 µM 2.8336030169944 0.0022460205802246 no 31 0.00230132350663092 57 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2446 5162541 200 µM 2.82350009812921 0.00231885564248003 no 32 0.00237512057009119 48 1549321
SGTC_1357 1503-1303 39.5 µM 2.79859825634098 0.00250759909295399 no 33 0.0025662475634994 113 292895
SGTC_303 1348-1668 34.2 µM 2.79607793095827 0.00252745584938075 no 34 0.00258634628810076 45 5380509
SGTC_145 3737-0113 38.366 µM 2.75734536773236 0.00285102374001638 no 35 0.00291363837370358 167 6849351
SGTC_1127 asiatic acid 681.4 nM 2.68717437543195 0.00353368239284085 no 36 0.00360296616743638 110 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_888 0916-0002 6.97 µM 2.65730033473837 0.0038664278691103 no 37 0.00393846173158834 111 2802138 YIL048W NEO1
SGTC_1868 st057644 42.7 µM 2.65469263432424 0.00389676508908215 no 38 0.00396903507698375 114 688665
SGTC_77 0828-0286 12.516 µM 2.64313576923424 0.00403379692696571 no 39 0.00410710450291026 134 745345
SGTC_1725 st036284 20.55 µM 2.63333993443437 0.00415330911812395 no 40 0.00422748389664952 115 707914
SGTC_285 1486-1325 46 µM 2.61466540407129 0.0043899524949851 no 41 0.00446574516566453 85 22310230
SGTC_1686 st019653 115.5 µM 2.59844335739945 0.00460521932598715 no 42 0.00468237468888686 71 97252
SGTC_515 4092-1064 102 µM 2.56971269874103 0.00500969068136267 no 43 0.00508914438563592 162 717353
SGTC_96 0929-0093 37.281 µM 2.56968243248792 0.00501013294760237 no 44 0.00508958898665324 84 6991579
SGTC_34 0469-0683 81.75 µM 2.56927932792065 0.00501602663799776 no 45 0.00509551375452382 107 3690923
SGTC_146 3448-8650 53.125 µM 2.56595806949151 0.00506482141684801 no 46 0.0051445632637954 270 2891488 YIL048W NEO1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.5496386245407 0.0053107738851805 no 47 0.00539173154204682 68 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.54640112002243 0.00536081067204839 no 48 0.00544200208771096 300 16725076
SGTC_61 0978-8327 98.565 µM 2.54499371394791 0.00538269304060867 no 49 0.00546398527342364 116 6150059 YHR072W ERG7
SGTC_256 clotrimazole 625 nM 2.52542053810942 0.00569535423831093 no 50 0.005777995589998 141 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1290 0986-0249 10.2 µM 2.52040297667596 0.00577805702957275 no 51 0.00586102746343346 80 53329
SGTC_796 1234-0020 70.7 µM 2.51212450958888 0.00591683952341644 no 52 0.0060003369770841 105 46495034
SGTC_1245 0418-0076 17.2 µM 2.50703073254153 0.00600369474940975 no 53 0.00608750627347229 123 6790114
SGTC_3041 9091929 49.47 µM 2.49422662282427 0.00622703113461523 no 54 0.00631159608793596 107 25236887
SGTC_1443 4112-3303 14 µM 2.47257201123689 0.00662152107831256 no 55 0.00670723424775109 95 704433
SGTC_2152 5568786 200 µM 2.46513134904373 0.00676208325959884 no 56 0.00684815166697187 104 5399883
SGTC_738 1315-0003 72.4 µM 2.44968614055041 0.00706230256483935 no 57 0.00714903927072676 125 6251474
SGTC_802 4112-3352 742 µM 2.44223357953138 0.00721132536190046 no 58 0.00729834949632785 131 704594
SGTC_1324 1418-0026 34.4 µM 2.43229305236012 0.00741441118128283 no 59 0.0075017813148911 117 1372513
SGTC_250 brefeldin a 552.239 µM 2.42865175579204 0.00749005478690225 no 60 0.00757754061583296 85 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2229 7354935 190 µM 2.42388835470136 0.00759003470122595 no 61 0.00767766268200117 68 318112
SGTC_144 4161-2749 112.381 µM 2.39983719097673 0.00811300409520172 no 62 0.008201182668605 106 797501 YMR168C CEP3
SGTC_2280 7785178 200 µM 2.39479409011543 0.00822659381754689 no 63 0.00831485065274841 98 2954328
SGTC_1421 4029-0249 71.4 µM 2.38413256108265 0.00847133983339135 no 64 0.00855971721136363 129 2894095
SGTC_1670 st016595 4.04 µM 2.38068477166321 0.00855184320919704 no 65 0.00864024616664019 119 597879
SGTC_3243 9134147 49.47 µM 2.37145298019325 0.00877071233848207 no 66 0.0088591504808911 64 24282180
SGTC_678 1218-2179 85.9 µM 2.37070467877244 0.00878866649643942 no 67 0.00887710532656771 61 6820081 YOR116C RPO31
SGTC_2457 5731572 11.68 µM 2.35236931790835 0.00923877131765012 no 68 0.00932712164302286 91 2865357
SGTC_2019 4016004 108 µM 2.3126337725429 0.0102839839541458 no 69 0.0103713915287403 152 45595336
SGTC_2404 5161160 200 µM 2.30422398637902 0.0105179719615024 no 70 0.0106050367002975 153 2831543
SGTC_1927 st060202 13.8 µM 2.27385559749045 0.0114019667894611 no 71 0.0114873350760004 139 688887
SGTC_493 zm226600 134 µM 2.26359279812126 0.0117149625713488 no 72 0.0117995856065271 160 5240098 A potassium channel opener. YCR052W RSC6
SGTC_170 4197-0004 226 µM 2.24965811891021 0.0121518648212995 no 73 0.0122353280162052 116 218692
SGTC_1612 st002233 45.4 µM 2.24626261338144 0.0122604419413206 no 74 0.0123435958871615 142 1035021
SGTC_1701 st028638 40.4 µM 2.22968132662937 0.0128028150125236 no 75 0.0128843032164768 159 3490878
SGTC_2732 terfenadine 20 µM 2.22812577534806 0.0128547460877106 no 76 0.0129360644577169 112 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1965 Pectolinarigenin 58.4 µM 2.22418558373857 0.0129871027700433 no 77 0.0130679802924911 128 5320438 An anti-inflammatory.
SGTC_3178 9107506 49.47 µM 2.21852206808381 0.01317941154262 no 78 0.0132596283073985 152 8897194
SGTC_1108 betulinic acid 729.144 nM 2.21537609407297 0.0132872946649968 no 79 0.0133671303974513 154 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1602 st001878 87.6 µM 2.19749642468519 0.0139150307911159 no 80 0.0139925057708616 153 595405 YLR310C CDC25
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.1894431082158 0.01420602476897 no 81 0.0142823246656967 182 5106787 A p450 inhibitor.
SGTC_1732 st034308 51.822 µM 2.17777509968958 0.0146369228381292 no 82 0.0147113922921967 191 830119
SGTC_1708 st033234 31.827 µM 2.17377394057221 0.0147872521924026 no 83 0.0148610582636231 155 674664
SGTC_427 1354-0053 47.3 µM 2.17163492547073 0.0148681614306216 no 84 0.0149416052478044 191 6813657
SGTC_412 gemfibrozil 100 µM 2.17029486665857 0.0149190434793107 no 85 0.0149922576286942 124 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1361 1608-0041 5.61 µM 2.15928323467093 0.0153428536270809 no 86 0.0154141000017238 170 X1361
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.15810308322444 0.0153888822011399 no 87 0.0154599090510733 196 5024745
SGTC_535 2293-4129 48.2 µM 2.15623933011081 0.0154618142459678 no 88 0.0155324909616248 252 396118 YIL048W NEO1
SGTC_87 0100-0052 35.5 µM 2.15434312649457 0.0155363204490993 no 89 0.0156066365775996 400 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_25 0118-0223 35.662 µM 2.14534432279318 0.0158941193402349 no 90 0.0159626635853169 175 5333628
SGTC_1145 3546-0597 10.2 µM 2.13541148865741 0.0162972367369099 no 91 0.0163637065344947 199 875334
SGTC_555 4296-0685 37 µM 2.13197614012712 0.0164386812995257 no 92 0.016504404039452 167 2908540 YHR072W ERG7
SGTC_3161 9100388 49.47 µM 2.13161439773451 0.0164536364017925 no 93 0.0165192795799634 136 25236368
SGTC_1659 st012954 42.1 µM 2.1304438877733 0.0165021073051712 no 94 0.0165674918648833 144 24207262
SGTC_1788 fluconazole 20 µM 2.12535968776987 0.0167140654044647 no 95 0.0167783056541863 221 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.11989427813338 0.0169445093417881 no 96 0.017007481026771 104 4620898
SGTC_2989 9073649 71.4286 µM 2.11907586251629 0.0169792498605295 no 97 0.0170420281187955 258 21367202
SGTC_300 r073-0011 5.04 µM 2.10939528712143 0.0173948171612507 no 98 0.0174552379803578 200 2735780
SGTC_215 1287-0124 461.5 µM 2.10632604085508 0.0175283741007189 no 99 0.0175880203969953 99 5560863
SGTC_2472 5377652 49.4 µM 2.10309432228293 0.0176699461219313 no 100 0.0177287625938222 252 1610903
SGTC_335 4077-0256 27.6 µM 2.09631671034587 0.0179700247375368 no 101 0.0180270526812461 201 3121989
SGTC_663 1486-0733 13.9 µM 2.08221199082064 0.0186084631979446 no 102 0.0186615552497157 266 722445 YPR165W RHO1
SGTC_1548 st061468 90.8 µM 2.07595318586461 0.0188978896769746 no 103 0.0189491404685292 148 390799
SGTC_3174 9107204 49.47 µM 2.07225900331312 0.0190705106470304 no 104 0.0191206467472331 203 3938802
SGTC_2552 juarezic acid 87.02 µM 2.07095638104163 0.0191316981952923 no 105 0.0191814362503556 237 1549512
SGTC_1713 st033146 12.748 µM 2.07003251858854 0.0191751955089385 no 106 0.0192246496727514 218 674619
SGTC_2150 5556613 200 µM 2.06788446132279 0.0192766554648387 no 107 0.0193254444555389 202 743190
SGTC_1269 0831-0796 3.05 µM 2.06125358652834 0.0195927365529509 no 108 0.0196394268248696 183 927758
SGTC_203 k066-0004 30.888 µM 2.05309473456699 0.0199876827674732 no 109 0.0200316952700791 248 6795412
SGTC_258 haloperidol 50.781 µM 2.05115521319324 0.020082556689352 no 110 0.0201259169236258 249 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2120 5538279 151.968 µM 2.04972334636513 0.020152842940495 no 111 0.0201957177233147 203 2058197
SGTC_1706 st031321 9.9705 µM 2.03608312091448 0.0208329232439354 no 112 0.0208710046768868 161 6103185
SGTC_1277 0873-0036 22 µM 2.03050090455487 0.0211167945255627 no 113 0.0211528246588656 249 5965735
SGTC_2482 5981709 142.65 µM 2.02613585114312 0.0213410434256296 no 114 0.0213754325577071 251 877755
SGTC_131 0141-0277 33.849 µM 2.0138921937874 0.021980816683686 no 115 0.0220104266510432 245 1547771
SGTC_2095 5432005 200 µM 2.00816171501814 0.0222857726854953 no 116 0.0223130549412721 185 783734
SGTC_2802 7925815 54.55 µM 2.00433198873727 0.0224915609375082 no 117 0.0225172546976323 255 1262923
SGTC_1917 st066507 28.5 µM 2.0025468426595 0.0225880309746028 no 118 0.0226129752130756 273 3156428
SGTC_392 N-ethylmaleimide 8.33 µM 1.99171545679955 0.0231808722569364 no 119 0.0232011434108136 205 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1385 3091-4834 14.1 µM 1.98910803347249 0.0233255262228261 no 120 0.0233446399086918 197 4072814
SGTC_616 4092-0450 108 µM 1.98524720036687 0.0235411112930097 no 121 0.0235584876189415 247 787165
SGTC_2653 dihydrofissinolide 100 µM 1.98418152390283 0.0236009119296635 no 122 0.0236178037391237 157 6857746
SGTC_2181 6316240 54.2555 µM 1.98336391888281 0.0236468785597933 no 123 0.0236633971771331 206 12779990
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.9819926600619 0.0237241412235873 no 124 0.0237400310773925 206 2374 Ca(2+)-ATPase inhibitor.
SGTC_2990 9074105 71.4286 µM 1.97875218645721 0.0239075673770203 no 125 0.0239219570845235 183 6502001
SGTC_1619 st003326 88.7 µM 1.97593997102805 0.0240677167591699 no 126 0.0240807882091896 176 2849032
SGTC_1146 3579-1023 7 µM 1.97429672330868 0.0241617125598199 no 127 0.0241740066374069 250 X1146
SGTC_1963 st076565 50.3 µM 1.97410497268027 0.0241727009962408 no 128 0.0241849040206897 186 4914280
SGTC_1901 st060216 58.6 µM 1.96559817913963 0.0246644311279577 no 129 0.024672522306874 229 688792
SGTC_3220 9131269 49.47 µM 1.95658791538458 0.0251943889226311 no 130 0.0251979684758101 164 17722206
SGTC_1555 citronellol 128 µM 1.95397369539091 0.0253499240640681 no 131 0.0253521640574315 161 8842 A terpine precursor.
SGTC_1447 4239-0816 81.9 µM 1.95307909513377 0.0254033334192915 no 132 0.0254051118218557 239 1341554
SGTC_2106 5357045 167.29 µM 1.93686638591121 0.0263877116880529 no 133 0.0263808391768449 240 668842
SGTC_451 chloral hydrate 100 µM 1.93176257418383 0.0267041183683867 no 134 0.026694408708055 323 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_554 4483-2211 187 µM 1.93059312248549 0.0267770620694711 no 135 0.0267666945268083 231 747107
SGTC_1030 k029-0042 36.7 µM 1.93005150219724 0.0268109015739514 no 136 0.0268002283496341 280 6080581
SGTC_259 usnic acid 108.925 µM 1.91964930277479 0.0274677726684907 no 137 0.0274511059927377 250 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2969 9091408 28.7 µM 1.9184331904691 0.0275454356692414 no 138 0.02752805295586 271 4286311
SGTC_94 0334-0113 514.748 µM 1.91769243175051 0.0275928314304612 no 139 0.0275750109758416 255 6795178
SGTC_2370 9071495 200 µM 1.90421792003344 0.0284668995396998 no 140 0.0284409044085171 263 21791103
SGTC_1638 st008370 60.6 µM 1.90307714391679 0.0285419457883955 no 141 0.0285152399181475 281 24207134
SGTC_208 k072-0098 12.366 µM 1.8977845551644 0.028892276231587 no 142 0.0288622342969291 326 5948901
SGTC_1964 st076914 61 µM 1.89428017089724 0.0291262018302134 no 143 0.0290939157880069 213 24208661
SGTC_1068 loratadine 26.9 µM 1.87953625763269 0.0301276934676856 no 144 0.0300856537981963 256 3957 A H1 histamine antagonist.
SGTC_2305 7443522 69.23 µM 1.87733849899357 0.0302793947479638 no 145 0.0302358574126284 257 5415886
SGTC_1756 st041558 35.5 µM 1.87691423799825 0.0303087523319354 no 146 0.0302649245607211 250 3955792
SGTC_2005 4024620 188 µM 1.87369874608284 0.030532022397952 no 147 0.0304859794332777 237 236743
SGTC_1325 1431-0015 227 µM 1.87182473113845 0.030662773210464 no 148 0.0306154277892789 236 1103340
SGTC_426 0988-0037 14.6 µM 1.87050369931161 0.0307552205115737 no 149 0.030706951885631 308 5383008
SGTC_1833 st055984 71 µM 1.86606863975913 0.0310672803526175 no 150 0.0310158814255646 244 676288
SGTC_125 0133-0007 11.75 µM 1.85460583650068 0.0318859791885124 no 151 0.0318262670325607 240 26541
SGTC_675 1309-0189 238 µM 1.84751738871836 0.0324011111556159 no 152 0.0323360951604972 254 4246530
SGTC_1870 st057514 26.5 µM 1.84725415057426 0.0324203726752721 no 153 0.0323551572876723 264 5393161
SGTC_2680 butyl paraben 22.24 µM 1.84633479676757 0.032487717263356 no 154 0.0324218041305568 206 7184 An antifungal and steroid mimetic.
SGTC_1822 st052468 42 µM 1.83953659102686 0.0329892896741938 no 155 0.0329181505405488 229 2873678
SGTC_479 n-linoleoylglycine 10 µM 1.83722231302605 0.0331614865817396 no 156 0.0330885414955832 218 6433346 An anti-infammatory.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.82871718811492 0.0338006938057833 no 157 0.0337209931092188 221 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_257 daunorubicin 18.5 µM 1.82379802742621 0.0341750000298054 no 158 0.0340913061112743 221 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2922 7999257 32.47 µM 1.82371530933435 0.0341813231864776 no 159 0.0340975615771256 227 2988377
SGTC_880 0833-0487 87.2 µM 1.82115104275733 0.0343778190155726 no 160 0.0342919500402166 267 76075
SGTC_1128 3448-9350 235 µM 1.82084106484888 0.0344016349105593 no 161 0.0343155100127736 272 619386
SGTC_1604 st002052 72.4 µM 1.81743407659595 0.0346642914962975 no 162 0.0345753369550551 276 6254834 YHR062C RPP1
SGTC_1438 4092-1045 4 µM 1.81597163277722 0.0347775404865776 no 163 0.0346873618591431 254 1351342
SGTC_3252 9135871 49.47 µM 1.81571104938557 0.0347977514436186 no 164 0.034707354105511 248 17682838
SGTC_2291 7917025 104.35 µM 1.81335920574775 0.0349805980538056 no 165 0.0348882185738091 333 2964612
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.81262784962824 0.0350376185969274 no 166 0.0349446197075882 213 15053
SGTC_3066 9117245 49.47 µM 1.81016888939211 0.0352298922614989 no 167 0.0351348002580074 274 17176980
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.80385296147032 0.0357277234697468 no 168 0.0356271803450912 314 6708784 An antioxidant flavonoid
SGTC_1011 4112-3381 17.4 µM 1.79206851285434 0.0366720016221208 no 169 0.0365609959623864 312 2877139
SGTC_2037 5169046 200 µM 1.78704141030242 0.0370809838966321 no 170 0.036965397936799 264 5718022
SGTC_2652 actinonin 100 µM 1.77073960604997 0.0384329363350113 no 171 0.0383020065296402 215 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_709 3807-1509 243 µM 1.76700839605112 0.0387479598783518 no 172 0.0386134111019747 223 1886677 YPL242C IQG1
SGTC_2284 7945075 39.21 µM 1.76398681938158 0.0390046082142187 no 173 0.0388670991667446 331 1245402
SGTC_1097 itavastatin 7.23 µM 1.75808457404312 0.0395099284906622 no 174 0.0393665600471822 328 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2987 9018338 71.43 µM 1.7537575632672 0.0398837578397536 no 175 0.039736028708463 317 5055682
SGTC_307 1501-1223 22.3 µM 1.75330670536151 0.0399228742623944 no 176 0.0397746875781548 282 2830329
SGTC_3298 9116858 71.43 µM 1.75290456263764 0.0399577904602998 no 177 0.0398091951529389 285 2506942
SGTC_2911 7942208 15.64 µM 1.74902779008691 0.0402956671283292 no 178 0.0401431079107701 266 1243384
SGTC_2580 diallyl disulphide 81.36 µM 1.74238049074727 0.0408804042330895 no 179 0.0407209436847906 301 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_639 0833-0042 114 µM 1.74156506799077 0.0409526054278254 no 180 0.040792289139625 342 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2303 7774051 200 µM 1.73341935691458 0.0416795552453983 no 181 0.0415105797762835 293 2953184
SGTC_2236 dapsone 200 µM 1.72908090393225 0.042070978296115 no 182 0.0418973081747717 310 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3163 9099914 49.47 µM 1.72755296532447 0.0422095380802439 no 183 0.0420342007830964 201 16268368
SGTC_294 k038-0071 157 µM 1.72068514170646 0.0428369072628668 no 184 0.042653987013006 360 24152826
SGTC_2674 ligustilide 100 µM 1.72048782843431 0.0428550424129624 no 185 0.0426719021361291 256 5319022 A signalling regulator.
SGTC_1433 4060-0023 7.6 µM 1.71984439589413 0.0429142236936949 no 186 0.0427303650710731 310 3840627
SGTC_3036 9090181 49.47 µM 1.71429291079121 0.0434275825510813 no 187 0.0432374722327909 261 25236586
SGTC_1288 0973-0013 65.5 µM 1.71363336314634 0.0434889005857456 no 188 0.0432980410926902 322 4315430
SGTC_909 3448-9333 149 µM 1.71010411820483 0.043818202382419 no 189 0.0436233107019864 298 3344074
SGTC_3256 9138902 49.47 µM 1.70188482491765 0.0445929162370783 no 190 0.0443884805137799 227 17228773
SGTC_292 k038-0015 474 µM 1.70086111163864 0.0446901748266121 no 191 0.0444845352623353 308 46368540
SGTC_1995 st072814 61.1 µM 1.69983470272716 0.0447878609557639 no 192 0.0445810109989426 308 5769371
SGTC_92 0063-0024 660.874 µM 1.69845833844197 0.0449191230709937 no 193 0.0447106447133531 352 3594437
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.69462654876338 0.0452861877576907 no 194 0.045073143720879 213 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3268 9137683 49.47 µM 1.68801466775757 0.045925241064442 no 195 0.0457042066697092 238 1953228
SGTC_1082 camptothecin 424.86 nM 1.68771216928587 0.0459546506833582 no 196 0.0457332473100282 331 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1282 0886-0010 32.4 µM 1.6872238865452 0.0460021546129992 no 197 0.0457801550145378 357 2836211 YNL267W PIK1
SGTC_3134 9127454 49.47 µM 1.68547426703766 0.0461726951795679 no 198 0.0459485527604807 293 24262820
SGTC_1677 st019204 53.9 µM 1.68519582265955 0.0461998827475293 no 199 0.0459753983806627 322 3945625
SGTC_782 0083-0095 30.5 µM 1.68209184348051 0.0465038294249681 no 200 0.046275515890821 380 3591729 An indicator and reagent.
SGTC_2007 4011539 71.82 µM 1.67772867366535 0.0469337894579472 no 201 0.0467000395624294 360 45595301
SGTC_497 capsazepine 133 µM 1.67630344522416 0.0470749245836488 no 202 0.046839385218108 301 2733484 A calcium channel blocker.
SGTC_2016 5121758 140 µM 1.67241856657644 0.0474613581934006 no 203 0.0472209067304882 395 2795203
SGTC_1951 sophoraflavanone G 9.2 µM 1.67149065968603 0.0475540332271066 no 204 0.0473124010429228 369 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_776 4476-4378 112 µM 1.66637284738978 0.0480677840471387 no 205 0.0478195877310813 299 2892008
SGTC_2134 5324836 1.464 µM 1.66551661700284 0.0481541687442149 no 206 0.0479048656092384 271 699272
SGTC_2287 7945887 168.79 µM 1.66349928021127 0.048358188080582 no 207 0.0481062674081023 331 1245853
SGTC_3258 9138477 49.47 µM 1.65885309054037 0.0488307012921377 no 208 0.048572699587077 316 4970355
SGTC_1404 3909-7820 48.3 µM 1.6567241060548 0.0490484462357039 no 209 0.0487876335122939 313 23741373
SGTC_1262 0737-0114 49.6 µM 1.64808777576067 0.0499397053491083 no 210 0.0496673302087053 414 765919
SGTC_2163 5671233 125 µM 1.64301800277737 0.0504688868305857 no 211 0.0501896042634568 375 701023
SGTC_495 decylubiquinone 155 µM 1.64021926661984 0.0507629264351014 no 212 0.0504797923743726 349 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_100 0086-0128 49.5915 µM 1.63941771040688 0.050847390010957 no 213 0.0505631478481028 416 93297
SGTC_1920 st075728 45.7 µM 1.63829093191063 0.0509663128779991 no 214 0.0506805092131321 353 3400306
SGTC_63 0099-0242 26.702 µM 1.63645349662084 0.0511607149233224 no 215 0.0508723553793506 434 3898502 YLR359W ADE13
SGTC_893 0958-0369 48.9 µM 1.63531250825241 0.0512817290117849 no 216 0.0509917763852753 392 6819948
SGTC_405 ebelactone b 50 µM 1.63509792950517 0.0513045128153928 no 217 0.0510142600763907 368 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2556 citropten 84.59 µM 1.63317912842698 0.051508607747775 no 218 0.0512156641463986 399 2775 A potential DNA crosslinker.
SGTC_523 1934-0222 13.7 µM 1.63253734454972 0.0515770155527744 no 219 0.0512831690399559 371 1361595
SGTC_1774 st048371 48.465 µM 1.63104432321886 0.051736436342525 no 220 0.0514404837062018 380 4242727
SGTC_1303 1160-0052 261 µM 1.62848218891092 0.052010926704496 no 221 0.0517113414326972 356 3562476
SGTC_2818 7996756 12.99 µM 1.62351564710202 0.052546303908365 no 222 0.0522396106206417 257 2241621
SGTC_3172 9105863 49.47 µM 1.61227805353368 0.0537738254867155 no 223 0.0534507234071266 225 2348785
SGTC_2850 9015429 58.44 µM 1.60699422416428 0.054358792492787 no 224 0.0540278175664516 352 6457570
SGTC_1539 benzyladenosine 56 µM 1.60318592090582 0.0547835187135291 no 225 0.0544468064458793 330 92208 A nucleotide analog.
SGTC_586 0957-0265 8.15 µM 1.59925876459589 0.0552242431521527 no 226 0.0548815589156004 291 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2051 5263410 176 µM 1.59539393838958 0.0556607020980245 no 227 0.0553120853344316 372 227584
SGTC_3355 9151058 44.0485 µM 1.59535331661445 0.0556653039742925 no 228 0.0553166245636287 354 17015728
SGTC_1564 D-Arginine 115 µM 1.59455762712066 0.0557555049721171 no 229 0.0554055972168619 385 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1503 4585-0012 61.3 µM 1.59032431855273 0.0562373421920267 no 230 0.0558808598776643 340 2922052
SGTC_1327 1436-0082 2.18 µM 1.58687920274593 0.0566318848945872 no 231 0.0562700030165086 356 15992205
SGTC_706 4262-0057 46.9 µM 1.58685290814056 0.0566349045783097 no 232 0.0562729813184717 380 883298
SGTC_2529 gangaleoidin 93.61 µM 1.58573534952159 0.0567633627960664 no 233 0.0563996783673282 322 4565183
SGTC_1485 3909-9022 254 µM 1.58411824270235 0.0569496479551765 no 234 0.0565834068581623 370 714516
SGTC_1243 0416-0003 5.65 µM 1.58106007924625 0.0573032535490365 no 235 0.0569321506960756 395 2141977
SGTC_246 cycloheximide 667 µM 1.57742804490096 0.0577254558539187 no 236 0.0573485333090002 319 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2587 piperic acid 92.2 µM 1.57577612891685 0.0579182886722736 no 237 0.0575387027864589 358 5370536
SGTC_923 1900-2434 73.3 µM 1.57401610810273 0.0581242976128074 no 238 0.0577418627527438 374 5910570
SGTC_401 neomycin 50 µM 1.5685021095212 0.0587734354621808 no 239 0.0583819990181702 338 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1985 st071382 65.5 µM 1.56656737252502 0.0590025469191048 no 240 0.058607924628859 361 6123237
SGTC_1831 st055328 12 µM 1.56355502064992 0.0593606635038798 no 241 0.0589610524697173 396 1103068
SGTC_2565 isoliquiritigenin 100 µM 1.56217250114301 0.0595255906726372 no 242 0.0591236784325357 317 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2762 leflunomide 42.06 µM 1.5605046783041 0.0597250307271486 no 243 0.0593203326417304 434 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2036 5160441 105 µM 1.55868165919028 0.0599436278065223 no 244 0.0595358724243388 468 134534 YIL048W NEO1
SGTC_1673 st016611 27.3 µM 1.55418670948353 0.0604852917269069 no 245 0.0600699433968066 424 5226799
SGTC_1104 tacrolimus 29.8 µM 1.55403421214754 0.0605037353659998 no 246 0.0600881280668331 418 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_843 0310-0051 143 µM 1.55046368264157 0.0609368283645784 no 247 0.0605151319054544 382 2065037
SGTC_769 0302-0231 76 µM 1.54668577976575 0.0613977100268124 no 248 0.0609695168749029 497 571869 YER009W NTF2
SGTC_3326 9140064 16.379 µM 1.54572727421985 0.0615150739804718 no 249 0.0610852236924093 371 1868434
SGTC_2930 9013230 14.89 µM 1.54354537715918 0.0617828891296325 no 250 0.0613492532456757 444 2995857
SGTC_465 cgp-37157 41 µM 1.54001883741638 0.0622176746923565 no 251 0.0617778808872008 262 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1821 st053465 65.6 µM 1.53872347997853 0.0623779767650399 no 252 0.0619359088078314 370 675086
SGTC_2836 9010338 19.48 µM 1.53819393629977 0.0624436011145934 no 253 0.0620006015835198 381 2994051
SGTC_207 4185-0010 4.486 µM 1.53721728984413 0.062564774404103 no 254 0.0621200538638727 489 3761753
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.53601788118399 0.0627138366675838 no 255 0.0622669974400308 429 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3015 9080845 49.47 µM 1.53555888461969 0.0627709538388026 no 256 0.0623233023208835 410 5296973
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.5341868998904 0.0629419242331063 no 257 0.0624918397495002 335 61125 An anti-inflammatory.
SGTC_890 0929-0006 47.2 µM 1.53390230960103 0.0629774339467714 no 258 0.0625268438639919 365 1378169
SGTC_1039 k821-0043 94 µM 1.53221199517694 0.0631886643902276 no 259 0.0627350647257367 402 15992768
SGTC_2733 amorolfine 100 µM 1.53202765910454 0.0632117333030765 no 260 0.0627578047477965 252 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_572 0960-0087 17.7 µM 1.52730299796595 0.0638052463669823 no 261 0.0633428421759925 477 6796365
SGTC_1775 st081588 35.1725 µM 1.52613637438885 0.0639524631181909 no 262 0.0634879524648913 443 1426443 YGL099W LSG1
SGTC_3290 9121031 71.43 µM 1.51581837982714 0.0652660189061216 no 263 0.0647826416018029 359 17014854
SGTC_1196 1588-0294 184 µM 1.50952470751981 0.0660774682579064 no 264 0.0655823730689754 383 6144269
SGTC_2178 5812956 200 µM 1.50437547365002 0.0667471592140132 no 265 0.0662423578677111 386 5403383
SGTC_205 1486-1330 71.903 µM 1.49853805051318 0.0675126921415452 no 266 0.0669967571487681 338 4118834
SGTC_2815 7968870 71.43 µM 1.49841374543137 0.0675290672626191 no 267 0.0670128936738362 467 2977326 YHR190W ERG9
SGTC_297 0986-0032 24 µM 1.49821619485145 0.0675550975707416 no 268 0.0670385446658627 360 2847425
SGTC_2056 5235370 200 µM 1.49553287670487 0.0679094340845416 no 269 0.0673877131516939 439 5511916
SGTC_3145 9085516 49.47 µM 1.49379658923552 0.0681394773502695 no 270 0.0676143966500662 420 25236195
SGTC_660 4031-1742 102 µM 1.4921164157016 0.0683626582312044 no 271 0.0678343145761029 483 6738706
SGTC_76 0433-0009 400.328 µM 1.4899261017555 0.0686544485191682 no 272 0.0681218337877788 350 2841569
SGTC_872 0588-0139 234 µM 1.48701042217057 0.0690443600610106 no 273 0.0685060291654833 456 2047100
SGTC_1046 2001-0062 216 µM 1.48661259849538 0.0690976927616868 no 274 0.068558579219284 439 739778
SGTC_286 k060-0067 22.9 µM 1.47440679071364 0.0707494933875829 no 275 0.0701860485879155 418 5985051
SGTC_2558 carylophyllene oxide 100 µM 1.47419841764631 0.0707779534471882 no 276 0.0702140878978169 446 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.47321454982818 0.0709124511492336 no 277 0.0703465965139606 422 140250 A respiratory chain inhibitor.
SGTC_2560 caryophyllene 100 µM 1.46895389562121 0.071497162451525 no 278 0.0709226473704423 485 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_126 0417-1624 672.48 µM 1.46574706545811 0.0719396870492617 no 279 0.0713586034418529 549 41912 YDL195W SEC31
SGTC_996 3970-0799 1.8 µM 1.46361357072088 0.0722352587976793 no 280 0.0716497812493222 589 6615648 YGL040C HEM2
SGTC_1180 1193-0155 285 µM 1.46095149343078 0.0726053637938678 no 281 0.0720143768274731 436 2921347
SGTC_2044 5102272 200 µM 1.45881358879845 0.0729036439203896 no 282 0.072308210729877 390 592666
SGTC_3126 9127922 49.47 µM 1.45662749856836 0.0732096159716843 no 283 0.0726096163833198 465 45595682
SGTC_2872 9044037 25.97 µM 1.45632317415945 0.0732522879626809 no 284 0.0726516510861682 353 6465195
SGTC_2947 9072639 7.68 µM 1.4434550221034 0.0750741109946976 no 285 0.0744461669982449 500 16488146
SGTC_2684 capsaicin 100 µM 1.44207529574471 0.075271480459601 no 286 0.0746405667020454 427 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1910 st062352 60.4 µM 1.44083587183218 0.0754491167522292 no 287 0.0748155282807825 460 2245730
SGTC_3209 9113616 49.47 µM 1.43788230623231 0.0758737143064464 no 288 0.0752337254258104 497 16649353
SGTC_1225 1216-0074 20.6 µM 1.43712080476895 0.0759834804471646 no 289 0.0753418353175098 448 4241466
SGTC_310 1273-0058 1.06 µM 1.43670995536055 0.0760427522644406 no 290 0.0754002125123344 704 2734232
SGTC_3224 9130643 49.47 µM 1.43563256031113 0.076198351488042 no 291 0.0755534622698563 448 17644395
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.43311111403667 0.0765634501097654 no 292 0.0759130428861357 345 279621
SGTC_2907 7721985 69.9 µM 1.43085329727524 0.0768915037150669 no 293 0.0762361321881633 454 3267881
SGTC_578 3460-0051 92 µM 1.42582559855471 0.077625849992201 no 294 0.0769593449249736 511 2876744
SGTC_637 1181-0519 7.26 µM 1.42467097856887 0.0777952433234595 no 295 0.0771261659838635 586 6252091 YGR060W ERG25
SGTC_340 k038-0059 454 µM 1.4240445714568 0.0778872603039679 no 296 0.0772167850330154 480 23733424
SGTC_811 0416-0114 265 µM 1.42304551824736 0.0780341885531166 no 297 0.0773614802100156 458 6612453
SGTC_2265 7929201 200 µM 1.42268213202253 0.0780876829753968 no 298 0.0774141613222079 470 1265108
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.4212911668757 0.0782927053125477 no 299 0.0776160651873528 515 5379071
SGTC_2759 disulfiram 3.38 µM 1.41987252658365 0.0785022270597977 no 300 0.0778223977629425 466 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_265 mycophenolic acid 32.932 µM 1.41931780991947 0.0785842697425595 no 301 0.0779031910375775 505 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_818 4072-2707 53.5 µM 1.41776181115333 0.0788147490264852 no 302 0.0781301585485214 425 882871
SGTC_1460 k062-0059 9.15 µM 1.41518343300837 0.0791977932118916 no 303 0.0785073603230714 443 1373085
SGTC_1627 st003713 25.6 µM 1.41474991640796 0.0792623346787824 no 304 0.0785709166288863 569 16195070 YER133W GLC7
SGTC_172 1112-0046 2.638 µM 1.41172321797554 0.0797140561188398 no 305 0.0790157370835958 411 2802135 YIL048W NEO1
SGTC_815 1582-0027 36.9 µM 1.41109851278529 0.0798075326073668 no 306 0.0791077842395388 474 3128206
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.41043817158639 0.0799064315284577 no 307 0.0792051704375674 554 91467 include heat shock
SGTC_2957 9076800 11.52 µM 1.40583893352633 0.0805978290749946 no 308 0.0798859790115085 434 16459615
SGTC_1182 1222-0449 220 µM 1.40181253754023 0.0812068130959788 no 309 0.0804856167676984 465 658318
SGTC_1515 3460-0031 42.1 µM 1.39820003067118 0.0817561463178346 no 310 0.0810265037895277 400 2876596
SGTC_2512 diallyl trisulfide 49.23 µM 1.39493908521742 0.08225442089653 no 311 0.0815171047411888 418 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3092 9117248 49.47 µM 1.39478906071856 0.0822773996479333 no 312 0.0815397293270093 471 17141857
SGTC_1293 1000-1278 195 µM 1.39406383368365 0.0823885484263053 no 313 0.0816491646466578 496 678847
SGTC_1345 1488-0192 31.4 µM 1.39242869694095 0.0826395653367136 no 314 0.0818963097700657 494 658348
SGTC_40 0327-0103 19.753 µM 1.3913008753121 0.0828130372484573 no 315 0.0820671042589144 481 409036
SGTC_688 0527-0193 473 µM 1.39064030890812 0.0829147670944527 no 316 0.0821672633211434 460 4007154
SGTC_106 0092-0003 11.579 µM 1.38722981307915 0.0834414931133477 no 317 0.0826858486482185 392 1072148
SGTC_1767 st044992 70.3 µM 1.3845426770874 0.0838582697910438 no 318 0.0830961749166798 501 9600693
SGTC_1018 4259-0013 28.1 µM 1.38154649563767 0.0843248210024426 no 319 0.0835554960264839 471 6801262
SGTC_1722 st034304 3.6505 µM 1.38007096963622 0.0845552975524047 no 320 0.0837823972961173 504 4036148 YLR033W RSC58
SGTC_2100 5377183 190 µM 1.37884506703079 0.0847471421538706 no 321 0.0839712640921287 531 2844202
SGTC_806 3966-4455 5.86 µM 1.37716777395775 0.0850101545493409 no 322 0.0842301913673379 437 714982
SGTC_162 k030-0015 37.8 µM 1.36940944003487 0.0862346849802631 no 323 0.0854356625338792 485 1809920 YMR134W ERG29
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.36750310102671 0.0865375797960922 no 324 0.0857338329677718 500 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_463 ikarugamyin 104 µM 1.36656302840675 0.0866872387464376 no 325 0.0858811561845027 389 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_69 0096-0274 206.684 µM 1.36650807172283 0.0866959937956805 no 326 0.0858897745639848 580 6741392
SGTC_393 acivicin 6.25 µM 1.35827789178548 0.0880146011367411 no 327 0.087187761356135 458 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2993 9054257 71.4286 µM 1.35765798874242 0.0881145219044057 no 328 0.0872861166234832 529 6470217 YGL055W OLE1
SGTC_853 0419-0306 21 µM 1.35527164982977 0.0884999599143283 no 329 0.0876655120101498 488 762713
SGTC_1022 4477-0945 21.3 µM 1.35292389851166 0.0888803897354443 no 330 0.0880399718387143 518 4648966
SGTC_924 2046-0044 21.3 µM 1.34975221071936 0.0893962619469557 no 331 0.0885477393540803 507 3623589
SGTC_2154 5570129 200 µM 1.34954679208546 0.0894297497420486 no 332 0.0885807006688266 552 673366
SGTC_1158 4092-0494 91.8 µM 1.34720253262865 0.0898125771091076 no 333 0.0889575062570831 534 1148199
SGTC_3250 9135583 49.47 µM 1.3451929207625 0.090141723709206 no 334 0.0892814708811265 487 7699353
SGTC_787 4152-0075 138 µM 1.34388773887432 0.0903559739101227 no 335 0.0894923457381473 505 9566539
SGTC_2464 5717415 7.67 µM 1.34335799739883 0.0904430406471986 no 336 0.0895780403006702 535 5285744
SGTC_1023 4482-3888 16 µM 1.34061559510758 0.090894769918598 no 337 0.0900226456356714 495 3303168
SGTC_3167 9103034 49.47 µM 1.34042457897909 0.090926296394544 no 338 0.0900536746366619 432 5127859
SGTC_3037 9091026 49.47 µM 1.33851959017516 0.0912411514384828 no 339 0.0903635593279018 639 25236398 YIL048W NEO1
SGTC_2838 9002687 71.43 µM 1.33589417915782 0.0916764010814051 no 340 0.0907919318979737 473 6457060
SGTC_2089 5281248 129.67 µM 1.33488946600034 0.0918433722402629 no 341 0.0909562629830407 526 2737878
SGTC_171 k064-0041 9.68 µM 1.33308062422318 0.0921445474716775 no 342 0.0912526735489006 424 53325
SGTC_1067 clotrimazole 1.36 µM 1.33080718574637 0.0925241150025298 no 343 0.0916262314674825 555 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2534 helenine 20.12 µM 1.32761979153871 0.0930582202659993 no 344 0.0921518714535974 459 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2842 9000675 19.48 µM 1.32656989628716 0.093234647102912 no 345 0.092325499755293 489 2989072
SGTC_1728 st035614 33.7865 µM 1.32643029732695 0.0932581242399782 no 346 0.0923486044066779 580 15945546
SGTC_355 1311-2252 105 µM 1.32423398974156 0.0936280647027645 no 347 0.0927126728323295 541 5338538
SGTC_2343 7990716 14.84 µM 1.32413610429022 0.0936445774662261 no 348 0.0927289233762272 541 6456862
SGTC_999 SEC7.066 22.7 µM 1.31833412508747 0.0946271861035936 no 349 0.0936959110792155 565 740511 YDR170C SEC7
SGTC_1912 st060209 90.8 µM 1.3176325085524 0.094746523309888 no 350 0.0938133488377516 511 688787
SGTC_3000 9075062 71.4286 µM 1.31278393612224 0.0955742447256411 no 351 0.0946278822458367 514 17057871
SGTC_3191 9110352 49.47 µM 1.30845980923657 0.0963169140710977 no 352 0.0953586989650754 494 17122424
SGTC_2801 7907800 81.82 µM 1.30680455353446 0.0966023241433586 no 353 0.0956395491466787 565 6620925
SGTC_1651 st011928 86.1 µM 1.30551409478341 0.0968252641332071 no 354 0.0958589254380624 542 720198
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.30497530949142 0.0969184565336182 no 355 0.0959506276733928 527 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_944 3370-0224 231 µM 1.30326621200386 0.0972145107726373 no 356 0.0962419460648857 537 4580514
SGTC_2234 tolnaftate 200 µM 1.30246761774614 0.09735307257439 no 357 0.0963782903766561 455 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1413 3910-0535 34.4 µM 1.29858883193693 0.0980281307586193 no 358 0.0970425363457509 553 2876951
SGTC_2368 9071271 200 µM 1.29714961921983 0.0982794796985817 no 359 0.09728985578598 543 27209959
SGTC_2943 9068529 45.32 µM 1.29589144145892 0.0984995985122823 no 360 0.0975064441258508 593 3270634
SGTC_1865 st057639 52.2 µM 1.29546392856618 0.098574474201705 no 361 0.097580118540727 546 688818
SGTC_3253 9135987 49.47 µM 1.29079470362488 0.099394968194222 no 362 0.0983874374223716 497 4182430
SGTC_2795 7780010 54.55 µM 1.28891243238667 0.099727136172083 no 363 0.0987142656984702 509 953673
SGTC_573 3702-0553 84.7 µM 1.28617359880575 0.100211910805831 no 364 0.0991912414108861 548 1222756
SGTC_3102 9121669 49.47 µM 1.28583406936904 0.100272127286782 no 365 0.0992504886504099 503 41905072
SGTC_2507 purpurin 79.67 µM 1.28441632834125 0.100523852945618 no 366 0.0994981613689687 570 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2655 perillic acid 100 µM 1.28051565760025 0.101218811430778 no 367 0.100181920813281 491 5702197 An apoptosis inducer.
SGTC_318 1488-0629 67.2 µM 1.2798158649221 0.101343858675396 no 368 0.100304951450665 519 3662576
SGTC_1316 1272-0050 65.9 µM 1.27942875511841 0.101413080370372 no 369 0.100373056627329 559 7340392
SGTC_1223 0764-0573 147 µM 1.27705511824113 0.101838279414406 no 370 0.100791394325432 596 1609797
SGTC_2972 9093619 59.92 µM 1.27567736663436 0.102085675979562 no 371 0.101034796302474 534 25236256
SGTC_3279 9140807 49.47 µM 1.27379285497122 0.102424776832858 no 372 0.101368419017772 549 45595718
SGTC_887 0885-0007 9.62 µM 1.27346007367911 0.102484742810234 no 373 0.10142741591057 598 5719458
SGTC_820 1582-0060 59.9 µM 1.27178090004715 0.102787713162124 no 374 0.101725488532163 577 3848840
SGTC_2775 cyproheptadine 69.59 µM 1.26901825398226 0.10328758792664 no 375 0.102217276831496 575 2913 A selective serotonin reuptake inhibitor.
SGTC_2377 9073351 62.6 µM 1.26860067926733 0.103363297425842 no 376 0.102291760972188 562 7337946 YHR072W ERG7
SGTC_2731 amoxapine 43.43 µM 1.26678283329747 0.103693356290394 no 377 0.10261647598111 433 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_614 0462-0418 107 µM 1.26182859044505 0.104596758162514 no 378 0.10350523598984 512 5188303
SGTC_3343 9148379 18.9835 µM 1.25893998765936 0.105126116426134 no 379 0.104026004483186 576 1955036
SGTC_2657 nystatin 74.44 µM 1.25892119120833 0.105129567355186 no 380 0.104029399390396 593 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1349 flufenamic acid 69 µM 1.25873749743921 0.105163296875834 no 381 0.10406258133469 539 3371 A non-steroidal anti-inflammatory.
SGTC_2553 4-methylesculetin 85.09 µM 1.25839430763433 0.105226333753893 no 382 0.104124594770319 584 5319502
SGTC_2776 terbinafine 19.92 µM 1.25836418507677 0.105231867950405 no 383 0.104130039110742 551 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1956 st077085 54 µM 1.25174787449422 0.106452542535972 no 384 0.105330874650594 619 24208685
SGTC_2319 6033012 152.6 µM 1.24763225690647 0.107216991562262 no 385 0.106082879984596 516 847246
SGTC_2054 5233173 129 µM 1.24725970426042 0.10728638565174 no 386 0.106151143749156 634 6889
SGTC_2153 5569715 200 µM 1.24722252431179 0.107293312808468 no 387 0.106157958066354 564 2054701
SGTC_2451 5856223 45.7 µM 1.24715127922195 0.107306587689656 no 388 0.106171016703761 569 2179896
SGTC_1682 st012968 530 nM 1.246585076073 0.107412128702108 no 389 0.106274838328743 535 24207270
SGTC_2338 7999974 200 µM 1.24551716622905 0.107611392106282 no 390 0.106470854741638 636 315925
SGTC_1136 pergolide 1.05886 µM 1.24224810374387 0.108223028263825 no 391 0.107072518186128 680 47811 A dopamine receptor agonist.
SGTC_1650 st011916 45.8 µM 1.24036945243022 0.108575650930521 no 392 0.107419387196541 550 242528
SGTC_2677 mitomycin C 100 µM 1.23632262564493 0.109338045844701 no 393 0.108169332082041 542 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1356 1502-0781 85.8 µM 1.23253811782817 0.110054494420313 no 394 0.108874068410221 589 567702
SGTC_2224 6650123 117.647 µM 1.23205656633777 0.110145898360125 no 395 0.108963977249955 541 2908370
SGTC_3319 9138450 16.7555 µM 1.23158679873673 0.110235118044331 no 396 0.109051737375745 559 2029690
SGTC_1048 3161-0300 24.5 µM 1.23092403545816 0.110361080182257 no 397 0.109175638567307 622 2165101
SGTC_665 3914-0008 307 µM 1.22669948369653 0.111166407578111 no 398 0.109967780923259 597 1069549
SGTC_1287 0971-0001 34.6 µM 1.22567780726789 0.111361800319034 no 399 0.110159972430054 647 4665869
SGTC_1121 fusaric acid 630.51 nM 1.22398578691835 0.111685934902448 no 400 0.110478794645121 610 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2607 solasodine 47.35 µM 1.2179639846013 0.112844984946213 no 401 0.111618829658268 621 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1089 terbinafine 2.25 µM 1.21778652462823 0.112879271436327 no 402 0.111652553210724 581 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2635 hydroquinidine 100 µM 1.21644120987001 0.113139437421432 no 403 0.111908446803744 607 442912 An experimental heart treatment.
SGTC_2864 9034755 47.6 µM 1.21480550144792 0.113456337682414 no 404 0.112220141048893 598 4930451
SGTC_317 4495-0002 170 µM 1.21361047480539 0.113688260583088 no 405 0.112448252592331 553 15991618
SGTC_3053 9095903 49.47 µM 1.21042243877552 0.114308626421195 no 406 0.113058417988209 597 17174018
SGTC_1239 0337-0584 35.4 µM 1.21003220942687 0.114384727135758 no 407 0.113133266858777 663 914301 YML130C ERO1
SGTC_3030 9087619 49.47 µM 1.20975419460147 0.114438966293989 no 408 0.113186613719299 571 25236973
SGTC_346 4513-0042 7.16 µM 1.20691068186292 0.114994771428527 no 409 0.113733271746305 629 2827372
SGTC_2465 5809242 33.21 µM 1.20511853754883 0.115346056368524 no 410 0.114078772225757 592 2731748
SGTC_622 1348-1566 26.3 µM 1.20301320916898 0.115759703138795 no 411 0.114485604488665 681 7340407
SGTC_1172 0370-0043 85 µM 1.19847202690585 0.116655521449819 no 412 0.115366653359616 590 376585
SGTC_1588 farnesol 29.9 µM 1.19842047735176 0.116665718533625 no 413 0.115376682233467 624 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1123 mangostin 811.285 nM 1.19632332412558 0.117081095107952 no 414 0.115785205108104 611 5281650 An antioxidant.
SGTC_949 1165-0505 146 µM 1.19206851094902 0.11792704973321 no 415 0.116617191410084 669 6244267
SGTC_1326 1431-2094 10.8 µM 1.18963719312795 0.118412388607656 no 416 0.117094510402563 644 616278
SGTC_1391 3442-0225 151 µM 1.18814792036357 0.118710373141898 no 417 0.11738756881572 573 5227075
SGTC_856 0433-0016 11.3 µM 1.1852216990809 0.119297415021325 no 418 0.117964901339769 660 3911780
SGTC_922 1866-0035 480 µM 1.18462478316994 0.119417416056857 no 419 0.118082916864334 734 3156169
SGTC_3115 9123671 49.47 µM 1.18361366212278 0.119620881131311 no 420 0.118283014866865 643 3286988
SGTC_892 0929-0076 29 µM 1.18239023833938 0.11986739405217 no 421 0.118525447354864 675 5751038
SGTC_1816 st051957 91.6 µM 1.17797053634058 0.12076092205821 no 422 0.119404176284253 642 674121
SGTC_511 blebbistatin 171 µM 1.1757622094811 0.121209130155633 no 423 0.119844955782227 626 3476986 A myosin inhibitor.
SGTC_2791 5663188 71.43 µM 1.17485332506403 0.121393939281399 no 424 0.120026700897172 595 54690634
SGTC_3121 9125696 49.47 µM 1.17470958243946 0.121423185498284 no 425 0.120055462179127 605 1235365
SGTC_1607 st000305 50.6 µM 1.17290615645748 0.121790535836688 no 426 0.120416720227708 643 5457690
SGTC_560 2332-1943 155 µM 1.17175764807194 0.122024888782298 no 427 0.120647185402665 633 21177716
SGTC_1103 duloxetine 36.1 µM 1.17139776187328 0.122098388625337 no 428 0.120719465743129 721 60835 A selective serotonin reuptake inhibitor.
SGTC_2793 7325131 81.82 µM 1.16937643929359 0.122511782566215 no 429 0.121125999051771 605 4176441
SGTC_1563 conessine 56.1 µM 1.16303398631049 0.12381529102367 no 430 0.122407856773103 752 441082 An anti-amoebic, histamine inhibitor.
SGTC_2715 st079500 56.4 µM 1.16302011627721 0.12381815220798 no 431 0.122410670405003 607 28246688
SGTC_550 4123-0385 25.7 µM 1.16101255863745 0.124232770144969 no 432 0.12281839612726 631 5731123
SGTC_1763 st044482 94.5 µM 1.16095833473516 0.12424398238184 no 433 0.12282942194595 661 88505
SGTC_1209 2323-2347 50.3 µM 1.16074431797399 0.124288242960802 no 434 0.122872946615859 638 5412760
SGTC_2895 9054447 58.44 µM 1.16039660559837 0.124360176499225 no 435 0.122943684070507 619 2697450
SGTC_244 nsc-207895 1.295 µM 1.15802067935816 0.124852479115886 no 436 0.1234277987625 536 42640
SGTC_950 1165-0508 94.1 µM 1.15615071834854 0.12524089987517 no 437 0.123809756786624 618 6148369
SGTC_2883 9059145 45.46 µM 1.15481417886578 0.125519036987856 no 438 0.124083264746251 622 16476510
SGTC_3192 9110362 49.47 µM 1.15429880862064 0.125626401858655 no 439 0.124188842394738 689 16649480
SGTC_885 0865-0106 16.8 µM 1.15283984467616 0.125930688950725 no 440 0.124488063336499 650 2793380
SGTC_860 0443-0016 25.1 µM 1.14992012895836 0.126541178561665 no 441 0.125088384736854 668 5337942
SGTC_2321 7390090 138.78 µM 1.1491242166094 0.126707954570257 no 442 0.125252382030876 581 649046
SGTC_1459 k035-0031 35.7 µM 1.1485954069387 0.126818846300277 no 443 0.125361425937411 574 3877128 YMR208W ERG12
SGTC_2222 6885208 172.143 µM 1.1464234244766 0.127275021041301 no 444 0.125809997489845 625 609514
SGTC_216 k038-0035 28.382 µM 1.14479800712429 0.127617148305446 no 445 0.12614642053773 616 4444231 YPR107C YTH1
SGTC_3241 9133421 49.47 µM 1.14472292839714 0.127632966744692 no 446 0.126161975200667 635 17018221
SGTC_1516 st013856 110 µM 1.14347284683042 0.12789654843816 no 447 0.126421161104653 629 5281404 A mutagen and neurotoxin.
SGTC_1782 st039423 80.636 µM 1.1414265817063 0.128328822552429 no 448 0.126846224092662 610 2068169
SGTC_2939 9044578 71.43 µM 1.14017428089275 0.128593871294395 no 449 0.127106850101578 646 2653634
SGTC_2904 7225135 42.03 µM 1.13939073301561 0.128759901832 no 450 0.127270109699555 702 4446116
SGTC_657 3534-0529 86.7 µM 1.13725571115233 0.129213058585905 no 451 0.127715701732928 685 1049549
SGTC_2785 7756463 72.73 µM 1.13465157271765 0.129767280000967 no 452 0.128260667715147 643 2201551
SGTC_2865 9030313 51.95 µM 1.13314496698532 0.130088671480788 no 453 0.128576690207956 617 42562754
SGTC_2080 5212524 12.4 µM 1.13181039349217 0.13037382454239 no 454 0.128857078578183 646 260183
SGTC_177 1327-0068 8.361 µM 1.13112154424505 0.13052117730332 no 455 0.129001968790691 689 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2091 4-phenylthiadiazole 200 µM 1.13053425401639 0.130646896344417 no 456 0.129125586612835 691 270010
SGTC_1661 st013063 9.66 µM 1.12983577717358 0.130796525657385 no 457 0.129272714827187 734 721395
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.12768018969447 0.131259047214186 no 458 0.129727503476842 643 641818 YHR062C RPP1
SGTC_71 0417-1750 47.813 µM 1.12648597838692 0.131515773211342 no 459 0.129979936156129 719 6811472
SGTC_2867 9039098 71.43 µM 1.12480499925712 0.131877729273455 no 460 0.13033583777208 677 6463460
SGTC_1929 genistein trimethyl ether 50.5 µM 1.12300237672908 0.132266641068417 no 461 0.130718242519559 686 136420
SGTC_2450 5739737 12.93 µM 1.12109809524016 0.132678343512221 no 462 0.131123054690929 648 2262825
SGTC_2774 tamoxifen 10.92 µM 1.11898251139885 0.13313676323462 no 463 0.131573800008981 690 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_362 0310-0100 9.03 µM 1.11891411131296 0.133151602820134 no 464 0.131588391125492 656 790235
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.11861495990474 0.133216517911337 no 465 0.131652219271426 735 676296 Flavone; oxidizing agent.
SGTC_715 0868-0130 184 µM 1.1180610273326 0.133336777353725 no 466 0.131770464952664 653 2876258
SGTC_1863 st057641 20.1 µM 1.11695568751196 0.133576971146687 no 467 0.132006636187125 747 3921635
SGTC_1949 st076024 69.1 µM 1.11654939107107 0.133665335371651 no 468 0.132093520404247 659 2921930
SGTC_3301 9125354 19.7965 µM 1.11066693208421 0.134949198299203 no 469 0.133355870468055 619 41905162
SGTC_1657 st012939 43.4 µM 1.10633851377675 0.135899272604672 no 470 0.1342900138771 654 24207257
SGTC_1431 4049-0260 9.09 µM 1.10601634329181 0.135970170700677 no 471 0.134359722782546 717 3854841
SGTC_3322 9139058 2.11 µM 1.1059268029826 0.135989879787208 no 472 0.13437910127496 722 4908926 YPR165W RHO1
SGTC_714 4296-0578 26.1 µM 1.10375206378835 0.136469171268209 no 473 0.134850352080978 656 1589775
SGTC_1476 4112-3294 3.34 µM 1.10024056566361 0.137245508029007 no 474 0.135613660126869 688 704369
SGTC_1754 st042065 16.137 µM 1.09867949936232 0.137591601838982 no 475 0.135953943833067 804 1126236 YIL048W NEO1
SGTC_20 0481-0013 4.944 µM 1.09788555187132 0.137767851091663 no 476 0.136127233842484 696 182045
SGTC_226 1,3-diallylurea 8.28947 mM 1.09662497947655 0.138048003257788 no 477 0.136402681632201 659 74537 YKL182W FAS1
SGTC_1152 3909-8331 15.9 µM 1.0874324634144 0.140102711533361 no 478 0.1384228653606 682 16001939
SGTC_432 NS 1619 61.3 µM 1.08601420974148 0.140421559708957 no 479 0.138736352790354 649 4552 A K+/calcium channel activator.
SGTC_1484 3473-2379 286 µM 1.08243844766774 0.141227639121072 no 480 0.139528876001854 836 671917
SGTC_214 4373-3496 70 µM 1.08186806486156 0.141356509314347 no 481 0.139655578443636 897 3779166
SGTC_2471 5466956 24.79 µM 1.07947433286897 0.141898209277531 no 482 0.140188164939032 710 724419
SGTC_1626 st003712 1.76 µM 1.0789836702391 0.142009419261375 no 483 0.140297503664082 684 24207035
SGTC_347 4534-1311 26.2 µM 1.07752910717926 0.142339446479436 no 484 0.140621977172036 716 2862016
SGTC_1264 0783-0040 158 µM 1.07598603167192 0.142690123165666 no 485 0.140966751760777 687 2855798
SGTC_1546 5-methoxyflavanone 78.7 µM 1.07508530574409 0.142895090360812 no 486 0.141168268814054 769 147795
SGTC_1819 st053448 58.6 µM 1.07471121905259 0.142980275152046 no 487 0.14125201962859 727 2857616
SGTC_1092 toremifene 6.32 µM 1.07145866185192 0.143722374206698 no 488 0.141981624186429 777 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1481 3346-2004 36 µM 1.07076040938771 0.143882024806854 no 489 0.142138586288022 753 2770522
SGTC_2618 avocadyne 43.43 µM 1.06667168121404 0.144819285002045 no 490 0.14306005959869 728 3015189
SGTC_3082 9117008 49.47 µM 1.06451749821793 0.14531473892881 no 491 0.143547165905644 742 41448529
SGTC_1721 st082152 9.2685 µM 1.06375613635374 0.145490121696555 no 492 0.14371959336858 685 5296051
SGTC_758 0868-0029 16 µM 1.06345862031059 0.145558694380927 no 493 0.143787010508679 751 762687
SGTC_1785 bathophenanthroline 24 µM 1.06297338185313 0.145670580698206 no 494 0.143897011323207 721 72812 An iron chelator.
SGTC_1840 st055363 71 µM 1.06282998926349 0.14570365523641 no 495 0.143929528475761 690 676033
SGTC_583 1488-1091 88.9 µM 1.06142796265036 0.146027308804454 no 496 0.144247727339878 869 4303273
SGTC_2624 nerol 100 µM 1.06127359475221 0.146062973658768 no 497 0.144282791075794 723 637566 A natural product oil.
SGTC_904 1141-0088 396 µM 1.059113443492 0.146562664621334 no 498 0.144774059107373 716 1378119
SGTC_3147 9097027 49.47 µM 1.05431096218788 0.147677691811273 no 499 0.145870285754287 790 25236841
SGTC_1453 4237-0541 195 µM 1.05336427620275 0.147898159415106 no 500 0.146087035199528 774 739892
SGTC_1173 0443-0020 122 µM 1.05182325241189 0.148257509567307 no 501 0.146440324381848 736 5331295
SGTC_2273 7815444 169.05 µM 1.05075157377011 0.148507757559312 no 502 0.14668635115934 728 2824616
SGTC_2115 tiliquinol 12.7705 µM 1.04812315512523 0.149122715643286 no 503 0.147290934648717 732 71208 A bioactive hydroxyquinoline.
SGTC_2040 5100729 123 µM 1.04708169225026 0.14936685135199 no 504 0.147530951147637 765 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2266 7929956 200 µM 1.04266194555644 0.150405878851394 no 505 0.148552444234751 762 2967153
SGTC_2079 5212404 121 µM 1.04219476424158 0.150515988103494 no 506 0.148660695003327 770 758462
SGTC_3085 9117376 49.47 µM 1.04143259936996 0.150695736807152 no 507 0.148837409690353 750 16480349
SGTC_2072 5231554 129 µM 1.0407632670026 0.150853709761313 no 508 0.148992716063051 804 789545
SGTC_3309 9129340 25.759 µM 1.04073727194582 0.150859847226121 no 509 0.148998749925241 814 17158987
SGTC_2671 danthron 100 µM 1.03804502077616 0.151496391145942 no 510 0.149624547841905 742 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_698 k064-0052 127 µM 1.03763390439535 0.151593750613668 no 511 0.149720263550744 761 5088751
SGTC_85 0868-0259 160.055 µM 1.03727506591066 0.151678763758909 no 512 0.149803841351756 735 83173
SGTC_438 sphingosine 6.67 µM 1.0327155948209 0.152761716037325 no 513 0.150868506664304 663 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1962 st076595 64.5 µM 1.03142629862555 0.153068873723231 no 514 0.151170476767141 768 279619
SGTC_1572 epiandrosterone 68.9 µM 1.03139957120037 0.153075245505312 no 515 0.151176740932423 817 441302 A steroid.
SGTC_928 2764-0428 58.7 µM 1.03063044457176 0.153258679578914 no 516 0.151357076813426 816 662578
SGTC_1857 st056007 79.3 µM 1.0306069659632 0.153264281436851 no 517 0.151362584054261 753 619834
SGTC_3079 9117512 49.47 µM 1.03051127583547 0.153287113941888 no 518 0.151385030910052 843 7185044
SGTC_1950 st077106 7.18 µM 1.02825829342817 0.153825346523443 no 519 0.151914171993045 787 13831864
SGTC_2239 6685329 187.64 µM 1.02775714755977 0.153945239038443 no 520 0.152032039213897 767 805680
SGTC_734 2023-0417 80 µM 1.02601950912606 0.154361424817593 no 521 0.152441194150557 765 3935732
SGTC_155 k072-0202 43.6 µM 1.02477290967617 0.154660458597235 no 522 0.152735175832796 765 5857737
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.02377530419536 0.154900039371616 no 523 0.15297070873931 829 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2805 7950783 58.44 µM 1.02233719482477 0.155245840890079 no 524 0.15331066739823 816 1178958 YDL195W SEC31
SGTC_2656 pseudo-anisatin 100 µM 1.02003985940011 0.155799304526893 no 525 0.153854778627522 786 6708809 A neurotoxin.
SGTC_248 streptozotocin 5.23457 mM 1.01875254326441 0.156110006958959 no 526 0.154160230422925 825 5300 DNA alkylating agent.
SGTC_2792 7535235 81.82 µM 1.01866416477557 0.156131352670734 no 527 0.154181215398076 702 1281891
SGTC_1229 0139-0193 12.2 µM 1.01628759834433 0.156706076677281 no 528 0.154746226250828 833 3090752
SGTC_3267 9137951 49.47 µM 1.01420372689665 0.157211162709371 no 529 0.155242775320723 764 16643986
SGTC_2673 kobusone 100 µM 1.01408422956249 0.157240158732454 no 530 0.155271281233321 821 6710676 An epoxy ketone and protein crosslinker.
SGTC_2956 9076196 2.52 µM 1.01303347632776 0.157495275350064 no 531 0.155522085606678 791 16423868
SGTC_433 pimozide 108 µM 1.01150470516761 0.157866937383396 no 532 0.155887465143973 644 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_228 caffeine 993.056 µM 1.0102416453618 0.158174436046988 no 533 0.156189765673495 751 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2897 9048598 12.99 µM 1.00862685832414 0.158568136737533 no 534 0.156576810716401 749 6467404
SGTC_2362 9071156 126 µM 1.00852311589111 0.158593452096046 no 535 0.156601698098607 792 653133
SGTC_2352 9027995 87.8 µM 1.00848129037367 0.158603659160838 no 536 0.156611732604456 741 2997347
SGTC_2227 7312221 64.1025 µM 1.00790647213528 0.15874398097081 no 537 0.156749682135278 820 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3098 9119039 49.47 µM 1.00724690991216 0.158905090305332 no 538 0.156908067707309 793 17161528
SGTC_1826 st055655 41.6 µM 1.00388233650533 0.159728611787865 no 539 0.157717665706175 800 676168
SGTC_3275 9138069 49.47 µM 1.00334204027325 0.159861115812167 no 540 0.157847929336377 788 17617007
SGTC_473 2-arachidonoylglycerol 10 µM 1.00241716572381 0.160088101923327 no 541 0.158071077469278 777 5282280 An endocannabinoid.
SGTC_762 1165-0429 115 µM 0.999916428346772 0.16070289675454 no 542 0.158675476669926 800 5967793
SGTC_1968 st069590 43.6 µM 0.999809282093878 0.160729272570986 no 543 0.158701406482019 780 6384066
SGTC_1471 k673-0312 37 µM 0.996765240144925 0.16147979458281 no 544 0.159439237066091 805 24099884
SGTC_36 0335-0881 14.2 µM 0.996407507733053 0.161568144902772 no 545 0.159526093321927 848 23828853
SGTC_621 3584-0052 32.1 µM 0.995029845713192 0.161908684815667 no 546 0.159860874385773 848 2273927
SGTC_897 1000-0139 31.4 µM 0.992533602040002 0.162526913759578 no 547 0.160468648175534 805 6151020
SGTC_1469 k284-2957 126 µM 0.992125049844476 0.162628243388451 no 548 0.160568264136348 808 23884841
SGTC_2502 avocadyne acetate 18.59 µM 0.991189430208552 0.162860451744218 no 549 0.160796545392276 882 3952079
SGTC_1218 1348-1416 30.7 µM 0.990077882478689 0.163136603193232 no 550 0.16106802651832 796 6787668
SGTC_2467 5474540 200 µM 0.989798458483719 0.163206070758832 no 551 0.16113631922652 813 5413519
SGTC_2734 clemastine 41.6 µM 0.989761665164388 0.163215219373472 no 552 0.16114531311663 702 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.989023369082535 0.163398866236794 no 553 0.161325854067906 810 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_339 3091-4833 71.4 µM 0.988117606291907 0.163624352743404 no 554 0.16154752702129 804 3240077
SGTC_2242 6630449 61.2675 µM 0.981915124704078 0.165173864567871 no 555 0.163070831945943 702 691249 YDR170C SEC7
SGTC_1510 1123-0200 71.5 µM 0.981613728706726 0.165249400896512 no 556 0.163145090707969 887 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3234 9132280 49.47 µM 0.979340946237503 0.165819728905758 no 557 0.16370577257966 812 17612295
SGTC_2540 epiandrosterone 100 µM 0.978611069239054 0.166003152550863 no 558 0.163886093919151 983 441302 A steroid.
SGTC_2314 7727897 200 µM 0.978202079857463 0.166105991991502 no 559 0.163987194002229 810 900724
SGTC_3051 9093778 49.47 µM 0.976663223768122 0.166493302516676 no 560 0.164367953824361 777 17217378
SGTC_2018 5133068 143 µM 0.976629926232587 0.166501689522093 no 561 0.164376198977974 779 785362
SGTC_2889 9059656 51.95 µM 0.975167407614849 0.166870338744711 no 562 0.164738613145711 872 3949838
SGTC_2768 sulfasalazine 50.2 µM 0.97403842746048 0.167155274532107 no 563 0.16501872976856 830 5384001 An antioxidant and salicylic acid derivative.
SGTC_3223 9129970 49.47 µM 0.973278923275174 0.167347137120203 no 564 0.165207347369517 861 17248386
SGTC_2575 plumbagin 510 nM 0.973005065401727 0.167416352683811 no 565 0.165275392288327 802 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2855 9016525 58.44 µM 0.97232662800469 0.16758790218888 no 566 0.16544404038055 822 43811474
SGTC_1031 k035-0009 16 µM 0.971441366758116 0.167811919324817 no 567 0.165664268740575 900 5180959
SGTC_1448 4255-0083 152 µM 0.970705047320539 0.167998393237991 no 568 0.165847588861964 871 5399660
SGTC_1613 st002381 52.1 µM 0.967889514572196 0.168712660179766 no 569 0.166549775765874 859 551167
SGTC_1741 st038134 10.228 µM 0.965636262039485 0.169285687209353 no 570 0.16711311175481 889 1272587
SGTC_1814 st052110 31.539 µM 0.965448301483291 0.169333544048209 no 571 0.167160159251114 826 674163
SGTC_3158 9100007 49.47 µM 0.964438870900541 0.169590704780093 no 572 0.167412970984018 762 19297233
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.963433829143193 0.16984699620138 no 573 0.167664928173381 809 6710655
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.963383338915301 0.169859878047676 no 574 0.167677592172175 826 7104
SGTC_9 0092-0002 10.449 µM 0.962522028958207 0.170079725226981 no 575 0.167893721499271 839 759368
SGTC_3023 9089636 49.47 µM 0.962472974648645 0.170092251701405 no 576 0.167906036139154 888 17249241
SGTC_1993 st073995 70.8 µM 0.962360032651337 0.170121094739154 no 577 0.167934391414506 857 3098394
SGTC_3056 9094900 49.47 µM 0.962058770549937 0.170198046145727 no 578 0.168010041506393 814 25236784
SGTC_2781 5567276 71.43 µM 0.961708448964447 0.170287556862772 no 579 0.168098038528602 796 2853274
SGTC_1550 gossypolone 36.6 µM 0.959643667058772 0.170815742124959 no 580 0.168617291971893 883 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2198 6589944 200 µM 0.958627253502777 0.171076132284722 no 581 0.168873278965352 764 5290268
SGTC_3080 9117754 49.47 µM 0.958359186683457 0.171144849336206 no 582 0.168940834035231 910 9550191
SGTC_113 0099-0221 2.5 µM 0.956599267967281 0.171596430444624 no 583 0.169384779231794 823 89219
SGTC_1753 st043925 64 µM 0.955646522459908 0.171841214676375 no 584 0.169625424466186 878 670181
SGTC_1012 4112-3522 18 µM 0.954273839947204 0.17219428314074 no 585 0.169972523149293 884 3112398
SGTC_1667 st014849 34.6 µM 0.953943032124382 0.17227943958752 no 586 0.170056239777623 871 5348460
SGTC_3206 9114350 49.47 µM 0.953936263945756 0.172281182130401 no 587 0.170057952857855 784 17087243
SGTC_1147 3809-1045 12.3 µM 0.943747440117853 0.17491715379172 no 588 0.172649362579932 829 325925
SGTC_2468 5987765 72.9 µM 0.943448078472586 0.174994987323781 no 589 0.172725880537993 911 26772094
SGTC_3045 9092950 49.47 µM 0.943255399748344 0.175045095094654 no 590 0.172775141374568 900 44120432
SGTC_2591 skatole 100 µM 0.941227456040861 0.175573031384659 no 591 0.17329415472179 841 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_721 1187-1332 279 µM 0.938260320937093 0.176347284328665 no 592 0.174055322870237 771 25730
SGTC_636 0kpi-0074 126 µM 0.938028933738962 0.176407753851885 no 593 0.174114770531649 830 616434
SGTC_988 1497-1057 103 µM 0.937748124993884 0.176481156561705 no 594 0.174186932837847 900 3533044
SGTC_2812 7970281 58.44 µM 0.937258021025818 0.17660931480101 no 595 0.174312925416792 870 2233435
SGTC_2049 5262831 67.185 µM 0.936598573281465 0.176781847916764 no 596 0.174482543082907 854 763417
SGTC_2908 7930301 100 µM 0.934111872146381 0.177433408328323 no 597 0.17512309424977 917 2223178
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.932812956539464 0.177774349549762 no 598 0.175458275176252 844 803109
SGTC_1328 1441-0025 69.2 µM 0.932733492629047 0.177795220756737 no 599 0.175478793769937 824 4562601
SGTC_1524 corynanthine 62.1 µM 0.932307347394654 0.1779071742307 no 600 0.175588855843627 849 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1493 4348-0038 111 µM 0.931210115682749 0.178195634737073 no 601 0.175872443127245 934 800424
SGTC_596 1155-0152 116 µM 0.930970245679728 0.17825873543274 no 602 0.175934477840943 903 280313
SGTC_2092 5303694 80.6725 µM 0.929949955961993 0.178527292247963 no 603 0.176198497974656 870 1963699
SGTC_3141 9094609 49.47 µM 0.928844016195774 0.178818681208182 no 604 0.176484964818357 796 25236309 YDL196W YDL196W
SGTC_2259 7964009 200 µM 0.928714745449865 0.178852760522128 no 605 0.176518468485775 816 313134
SGTC_1153 4055-0057 267 µM 0.927096969974945 0.179279596157741 no 606 0.176938094609068 893 882706
SGTC_1942 st076330 65.2 µM 0.9249476796684 0.17984765720317 no 607 0.177496561728057 895 24208414
SGTC_1746 st038117 42 µM 0.924466884329749 0.179974886796511 no 608 0.177621642708977 867 2898218
SGTC_1685 st024049 53.0905 µM 0.921841208881109 0.180670698140956 no 609 0.178305704453387 867 1941139
SGTC_868 0527-0199 213 µM 0.921683333694728 0.180712589198638 no 610 0.178346888187919 890 2849450
SGTC_382 3229-0966 23.2 µM 0.920791362373996 0.180949381828954 no 611 0.17857968274061 917 5722370
SGTC_2293 7624732 200 µM 0.919232290889131 0.181363736992887 no 612 0.178987042323608 841 894453
SGTC_1086 cerivastatin 2.18 µM 0.918328983006782 0.181604081150188 no 613 0.179223329043491 875 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2603 homopterocarpin 100 µM 0.91759471874174 0.181799594469536 no 614 0.179415541918406 872 101795 A weak amylase inhibitor.
SGTC_1915 st067105 30.6 µM 0.91736124409179 0.181861789590196 no 615 0.179476687160314 874 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3348 9149464 3.537 µM 0.916728823353256 0.182030326469554 no 616 0.179642379147414 892 1951442
SGTC_1861 st057647 17.4 µM 0.916432355789524 0.182109367161814 no 617 0.179720085677247 901 688668
SGTC_3077 9117319 49.47 µM 0.916403841105841 0.182116970542018 no 618 0.179727560718012 857 17154678
SGTC_2119 5528445 120.635 µM 0.915810874105538 0.182275128910383 no 619 0.179883049543594 912 791935
SGTC_854 0422-0053 192 µM 0.912159851644721 0.1832508335066 no 620 0.180842287608732 914 3596728
SGTC_755 1995-0008 37.3 µM 0.908906370227817 0.184123037681254 no 621 0.181699775472197 920 689533
SGTC_981 1488-1094 54.9 µM 0.908751740704997 0.184164555506489 no 622 0.181740592870566 839 3449522
SGTC_1583 clindamycin 39.6 µM 0.906749770185609 0.184702607954069 no 623 0.182269568813636 796 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3074 9116018 49.47 µM 0.906537080995052 0.184759827977784 no 624 0.182325823661221 869 17027303
SGTC_1367 1812-0510 76.9 µM 0.906009845697766 0.184901718219613 no 625 0.182465320592476 892 1142582 YDR527W RBA50
SGTC_3341 9147222 25.867 µM 0.903386255164542 0.18560878872364 no 626 0.183160466126145 853 1939759
SGTC_2869 9037858 32.47 µM 0.902594978348999 0.185822370587195 no 627 0.183370446338205 918 27187042
SGTC_1253 0550-0034 176 µM 0.900743534320672 0.186322708647399 no 628 0.183862348031242 841 5969915
SGTC_178 4092-0806 87.505 µM 0.900721704422056 0.186328612978624 no 629 0.183868152815022 930 2169044
SGTC_947 3447-0010 211 µM 0.900676415378272 0.186340862672983 no 630 0.183880195979222 889 748350
SGTC_2441 5730946 39.09 µM 0.900470818895873 0.186396478291535 no 631 0.183934873926527 917 1774275
SGTC_1387 3342-1166 1.8 µM 0.900377259986017 0.186421790186039 no 632 0.183959759071329 849 3418228
SGTC_2060 5238662 140 µM 0.899362823671273 0.186696377533155 no 633 0.184229717180253 850 790130
SGTC_2113 5491891 107.031 µM 0.897073638497824 0.187316932959579 no 634 0.184839812156039 912 789979
SGTC_2231 micatex 6.853 µM 0.896900017666759 0.187364050299662 no 635 0.184886135340095 930 20737 An antifungal of unknown mechanism.
SGTC_2425 5628681 7.85 µM 0.896682022942474 0.187423220230858 no 636 0.184944307987088 996 5714958
SGTC_2832 7992762 51.95 µM 0.895941666826193 0.18762426001981 no 637 0.185141959473339 783 2985177
SGTC_202 3594-0513 34.79 µM 0.895446952822414 0.187758671221539 no 638 0.185274105442938 887 708429
SGTC_545 4218-0007 221 µM 0.894355270950935 0.188055485820941 no 639 0.185565918168078 865 2840508
SGTC_1090 efavirenz 20.7 µM 0.894132681451179 0.188116040640594 no 640 0.185625452585461 923 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2687 chenodiol 100 µM 0.892509430079034 0.18855800520657 no 641 0.186059970262268 862 5702181 A cholesterol synthesis inhibitor.
SGTC_2528 xanthyletin 44.79 µM 0.891668964015475 0.188787091251879 no 642 0.186285196741111 914 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_680 0417-1641 114 µM 0.889966175046438 0.189251746377993 no 643 0.186742024409512 862 2835990
SGTC_2251 lansoprazole 556 µM 0.88820392252801 0.189733368559783 no 644 0.187215534601624 755 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1600 coumarin 106 71.1 µM 0.886460898839338 0.190210476319001 no 645 0.187684607726338 945 100336 A hepatotoxic, DNA x-linker.
SGTC_2289 7946404 165.07 µM 0.885561103745547 0.190457060225265 no 646 0.187927039609362 973 1246120 YPR165W RHO1
SGTC_1272 0839-0021 27 µM 0.885389449677852 0.190504123365952 no 647 0.187973310333401 932 5027250
SGTC_3175 9106517 49.47 µM 0.884664754468857 0.190702894894396 no 648 0.188168735229302 906 41468073
SGTC_2979 9012552 45.46 µM 0.883678786850921 0.190973533293424 no 649 0.188434817383151 890 17100905
SGTC_952 1185-0122 232 µM 0.883480802286298 0.19102790649508 no 650 0.188488275255499 921 678600
SGTC_2367 9070478 135.38 µM 0.881199584533998 0.191655090137971 no 651 0.189104902063457 910 572802
SGTC_823 0417-1665 178 µM 0.880784351113951 0.19176938732333 no 652 0.189217275644031 942 3429856
SGTC_1342 1486-1464 234 µM 0.880109946371038 0.191955112948101 no 653 0.189399875706655 935 3253938
SGTC_2940 9060638 45.86 µM 0.87841310256665 0.19242289678564 no 654 0.189859788202134 905 4027022
SGTC_2336 9001819 198.65 µM 0.877815177989967 0.192587897844367 no 655 0.190022013137447 962 2989602
SGTC_1743 st037606 46.3785 µM 0.877752344684156 0.192605242111383 no 656 0.190039065599259 911 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_89 0302-0250 142.109 µM 0.876465800194287 0.19296058483033 no 657 0.190388430347951 1030 4203518 YLR208W SEC13
SGTC_3120 9124077 49.47 µM 0.875753544782863 0.193157481362816 no 658 0.190582014817773 979 18774327 YGL155W CDC43
SGTC_3110 9122132 49.47 µM 0.875631446339469 0.193191246677663 no 659 0.190615212180129 965 918317
SGTC_2191 5911152 200 µM 0.873022833766276 0.193913497409158 no 660 0.191325316013777 957 2875902
SGTC_1050 3232-1156 69.3 µM 0.869670460796835 0.19484408680372 no 661 0.192240259763194 897 700529
SGTC_264 promethazine 12.5 mM 0.865839982090319 0.195910712539585 no 662 0.193288960010465 1076 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2031 5180455 200 µM 0.865036141837344 0.196134996857182 no 663 0.193509476064488 942 29949
SGTC_1302 1159-0335 255 µM 0.863820519982672 0.196474470499929 no 664 0.193843246794767 922 649284
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.86326777973113 0.196628946012641 no 665 0.19399512750285 975 4174840
SGTC_3088 9117578 49.47 µM 0.862828352335817 0.196751806217924 no 666 0.194115924084524 982 678341
SGTC_510 ag-490 170 µM 0.862088972218942 0.196958635579412 no 667 0.194319279679123 1064 5328779
SGTC_597 k018-0003 82.8 µM 0.862011883919995 0.196980207330272 no 668 0.194340489143202 1047 6786234
SGTC_1616 st002734 56.1 µM 0.86127472540883 0.197186559877117 no 669 0.194543376273088 975 4026101
SGTC_741 4582-0002 126 µM 0.858699999708007 0.197908327596784 no 670 0.195253025319113 934 2912688
SGTC_1474 0330-0125 5.35 µM 0.856813118748029 0.198438285100696 no 671 0.195774087158969 993 X1474
SGTC_998 3996-0085 177 µM 0.854548158005169 0.199075561230351 no 672 0.196400669024977 1020 715391
SGTC_3196 9111891 49.47 µM 0.853266357391256 0.199436758212163 no 673 0.19675580606524 986 18891510
SGTC_1363 1636-0063 10.4 µM 0.852296765256795 0.199710240261844 no 674 0.19702470047226 997 6072185
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.85209870772464 0.199766131881429 no 675 0.197079654585388 976 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_308 4092-1169 104 µM 0.849260184792014 0.200568193317789 no 676 0.197868265226945 995 2268590 YDL196W YDL196W
SGTC_2123 5259487 200 µM 0.846877774263623 0.201242864546913 no 677 0.198531625993314 994 2173474
SGTC_2894 9048625 32.47 µM 0.846854816811413 0.201249372445039 no 678 0.198538024808234 992 4092861
SGTC_931 2812-0076 566 µM 0.846128229061369 0.201455408180485 no 679 0.198740607219246 995 3450959
SGTC_3321 9137793 26.8275 µM 0.845243145404638 0.201706558702346 no 680 0.198987548723728 992 4904192
SGTC_1845 st056753 3.01 µM 0.844642781467354 0.20187702411208 no 681 0.199155157607131 994 5375839
SGTC_1300 1094-0077 113 µM 0.844151864557372 0.202016477561261 no 682 0.199292274381679 914 5532636
SGTC_2418 pentamidine 31.67 µM 0.843803499980115 0.202115471516071 no 683 0.199389609696237 966 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3173 9105693 49.47 µM 0.843670653547633 0.202153229822923 no 684 0.199426735385291 1016 17096658
SGTC_1168 k815-0004 80.5 µM 0.842971244346257 0.202352089150342 no 685 0.199622263138615 967 642433
SGTC_3097 9117246 49.47 µM 0.842846404605619 0.202387596475656 no 686 0.199657175629258 1017 16423892
SGTC_2905 7799065 20.05 µM 0.840878060115438 0.202947931772657 no 687 0.200208125330545 954 1296806
SGTC_1070 indatraline 8.81 µM 0.840796377292634 0.202971204703703 no 688 0.200231008497781 963 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1955 wogonin 32.4 µM 0.837626258007901 0.203875660437521 no 689 0.201120320400376 968 5281703 A flavanone.
SGTC_1807 st050092 58.9 µM 0.837269827517717 0.203977502384042 no 690 0.201220457585335 948 5008496
SGTC_2665 lovastatin 100 µM 0.83574531631927 0.2044134389328 no 691 0.20164909787897 993 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2213 7173844 200 µM 0.834788801599554 0.204687238841991 no 692 0.201918316052067 1016 892728
SGTC_828 2074-0507 139 µM 0.834216718643415 0.204851100344945 no 693 0.202079435828826 1016 X828
SGTC_2359 9039622 200 µM 0.833415641233815 0.205080683686689 no 694 0.202305178184831 1018 6463596
SGTC_2728 chlorpromazine 9.18 µM 0.832896796964892 0.205229462492866 no 695 0.202451468133033 942 2726 A thorazine and dopamine antagonist.
SGTC_960 1222-0186 7.7 µM 0.831764537048025 0.20555436107233 no 696 0.202770932302444 987 3126296
SGTC_3212 9128307 49.47 µM 0.831339180140592 0.205676494820873 no 697 0.202891023425859 853 27243542
SGTC_2417 cerulenin 830 nM 0.831153907899821 0.205729705946603 no 698 0.202943344664071 997 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3075 9116269 49.47 µM 0.830906882866863 0.205800665493586 no 699 0.203013117543436 993 17015205 YNL244C SUI1
SGTC_1412 3909-8563 178 µM 0.82783540422635 0.206684179957568 no 700 0.203881860651525 1081 23767530
SGTC_1215 3852-0577 11.2 µM 0.827713010100103 0.206719433243552 no 701 0.203916524689444 1069 2884876
SGTC_1697 st025554 27.742 µM 0.826701728672806 0.207010849719127 no 702 0.20420307066113 985 1269519
SGTC_1575 cyproterone acetate 48 µM 0.822909345448414 0.208105846886712 no 703 0.205279773913807 981 9880 An androgen receptor antagonist and liver toxin.
SGTC_541 4513-1321 94 µM 0.822299846462886 0.208282149429283 no 704 0.205453132046453 924 747515
SGTC_1970 st070122 35.8 µM 0.821387826461875 0.208546123148473 no 705 0.205712697715512 1007 102928
SGTC_2013 4024628 200 µM 0.82136094589533 0.208553906411272 no 706 0.20572035101697 962 5230760
SGTC_196 k015-0023 18.111 µM 0.820874438949355 0.20869480400067 no 707 0.205858896062349 1015 5211998
SGTC_857 0438-0306 1.35 µM 0.816018679170439 0.210104155416744 no 708 0.20724472620498 1024 4686136
SGTC_2386 9075165 157.42 µM 0.815901111589253 0.210138347793087 no 709 0.207278348168124 999 16452277
SGTC_1632 st005650 90 µM 0.81337325275895 0.210874319574005 no 710 0.208002044895081 991 2759605
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.813023317036862 0.210976320347403 no 711 0.208102344848067 1066 5393153
SGTC_2636 apigenin dimethyl ether 100 µM 0.812497824762274 0.211129547421467 no 712 0.208253017117839 1000 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3242 9133940 49.47 µM 0.811377945258857 0.211456307998096 no 713 0.208574330288381 1084 17248444
SGTC_1809 st050081 57.6 µM 0.810744253739804 0.211641338845278 no 714 0.208756276969001 1029 5036894
SGTC_2945 9067681 61.76 µM 0.807825273247469 0.212494871402811 no 715 0.209595586962462 1054 16456930
SGTC_2880 9042983 58.44 µM 0.804876848236005 0.21335905171197 no 716 0.210445374817355 1017 6464714
SGTC_1250 0485-0349 40.2 µM 0.804821122537522 0.213375404559574 no 717 0.210461455390972 1017 6842794 YDL195W SEC31
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.80473007549819 0.213402124116302 no 718 0.210487730074523 1032 229346 A bile salt which induces apoptosis.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.804507248574321 0.21346752531699 no 719 0.2105520423945 1092 368090
SGTC_2954 9074818 52.69 µM 0.803275351910425 0.213829306026883 no 720 0.210907800527045 1006 16648742
SGTC_3324 9138759 60.749 µM 0.801968115000015 0.214213602682816 no 721 0.211285701270581 1036 45595710
SGTC_2419 paclitaxel 166.5 µM 0.801415235420656 0.214376257004894 no 722 0.211445648974317 1043 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2166 5933061 31.504 µM 0.801348151369989 0.21439599767189 no 723 0.211465061169344 1196 2877375
SGTC_2690 usnic acid 100 µM 0.801271814465036 0.214418462440563 no 724 0.211487152143722 1080 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2334 9017922 200 µM 0.80069436386486 0.214588441542161 no 725 0.211654303111908 1048 3163164
SGTC_2211 7117706 200 µM 0.798632994053017 0.215195867524325 no 726 0.212251625153583 1005 822771
SGTC_2846 9008642 19.48 µM 0.798224799198666 0.215316268997026 no 727 0.212370024328922 993 2992898
SGTC_3046 9092212 49.47 µM 0.797577211141335 0.215507362252048 no 728 0.212557939986756 1024 25236637
SGTC_1419 3993-2473 62.6 µM 0.796420618262361 0.215848899597215 no 729 0.212893799044274 1051 704026
SGTC_3280 9140961 49.47 µM 0.795962175881977 0.215984362596721 no 730 0.21302701022676 999 4901226
SGTC_1990 st072050 59.8 µM 0.79590738784473 0.216000554952264 no 731 0.213042933428109 1082 17233948
SGTC_3351 9150312 21.596 µM 0.794973469968438 0.216276678284818 no 732 0.213314467390426 1032 4904905
SGTC_524 r073-0010 27.8 µM 0.794751689917144 0.216342280066901 no 733 0.21337897894422 989 2772106
SGTC_1142 3253-1408 9.78 µM 0.794499976821116 0.216416749894474 no 734 0.213452211222904 1033 256655
SGTC_647 0140-0236 81 µM 0.794327848298356 0.216467683005427 no 735 0.213502297955633 1100 990837
SGTC_1860 st056228 74.6 µM 0.793900146918895 0.216594270568925 no 736 0.213626782078912 1046 688679
SGTC_2790 5423970 71.43 µM 0.79339251330522 0.216744571384998 no 737 0.213774585649817 1058 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3349 9149703 23.001 µM 0.791806959036464 0.217214412554074 no 738 0.214236622004844 1073 4910494
SGTC_703 3875-0075 71.8 µM 0.787052153572572 0.218626908004232 no 739 0.215625668285908 1106 2850814
SGTC_983 1491-0821 12.2 µM 0.786003619519751 0.218939102860797 no 740 0.215932683320389 1054 46495113
SGTC_539 4859-0462 2.54 µM 0.784864187118734 0.219278652737218 no 741 0.216266600755243 1091 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_980 1473-0395 201 µM 0.784684394342119 0.219332258463644 no 742 0.216319317390711 1006 768876
SGTC_748 act1.228 77.9 µM 0.781851209131284 0.220177974477841 no 743 0.217151010893457 1048 4421505 YNR035C ARC35
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.780818524410605 0.220486699043911 no 744 0.217454618645074 1047 616764
SGTC_359 0081-0058 15.9 µM 0.777809657842517 0.22138762282274 no 745 0.218340616760668 1031 3494159
SGTC_1429 4049-0205 9.46 µM 0.777388132816443 0.221514004986497 no 746 0.21846490589656 1125 22774478
SGTC_2913 7966556 36.57 µM 0.776644569948048 0.221737041449057 no 747 0.218684249084659 1025 2976516
SGTC_2537 larixol 68.93 µM 0.776620430668175 0.221744284330786 no 748 0.218691372040821 1085 6708759
SGTC_2817 7995342 71.43 µM 0.775785459017977 0.221994896978377 no 749 0.218937835494578 1044 18879975
SGTC_3078 9116413 49.47 µM 0.772170958926905 0.223081634861058 no 750 0.220006589696841 1065 17177322
SGTC_1395 3486-0190 4.35 µM 0.771619444477448 0.223247719511544 no 751 0.220169927162015 1123 6748079
SGTC_2962 9082311 13.18 µM 0.770743656404397 0.223511601419717 no 752 0.220429444911201 1072 16459453
SGTC_1648 st011736 69.8 µM 0.770185896562654 0.22367975133056 no 753 0.220594814343414 1080 2855514
SGTC_2317 5986382 200 µM 0.769008941029418 0.22403480836229 no 754 0.220944001371778 1112 877883
SGTC_1132 3456-3614 2.5 µM 0.768666841942353 0.22413807083003 no 755 0.221045556931634 1153 3125502
SGTC_2228 7354201 200 µM 0.766935278006189 0.224661157178082 no 756 0.221559998752617 1124 753451
SGTC_181 1447-1644 8.07 µM 0.766528428836904 0.224784162203242 no 757 0.221680971479406 1072 534600
SGTC_3035 9091303 49.47 µM 0.764236004560118 0.225477957245683 no 758 0.222363307052862 1103 25237002
SGTC_2458 5808907 16.39 µM 0.762620989797925 0.225967463320625 no 759 0.222844731478393 1168 2731747
SGTC_719 2810-4230 27.3 µM 0.760295318853043 0.226673421528894 no 760 0.223539039686999 1079 721079
SGTC_2686 alizarin 95.37 µM 0.759197389528691 0.22700713038172 no 761 0.223867243710076 1079 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_132 0417-1715 25.805 µM 0.757947455766313 0.227387377038658 no 762 0.224241219558062 1119 6769098
SGTC_2849 9019321 12.99 µM 0.757291176611092 0.227587169551181 no 763 0.224437717937657 1054 16489627
SGTC_1281 0884-0031 11.8 µM 0.752676331423291 0.228994865087746 no 764 0.225822218088758 1134 1548255
SGTC_2593 nobiletin 86.24 µM 0.752180166516414 0.229146503732348 no 765 0.225971359611532 1069 72344 An anti-infammatory.
SGTC_508 roscovitine 141 µM 0.751490413062465 0.229357400725914 no 766 0.226178784134199 1128 160355 A CDKinase inhibitor.
SGTC_2184 6075246 200 µM 0.751384645451928 0.229389749538954 no 767 0.226210600366853 1078 2267320
SGTC_2485 5633444 17.78 µM 0.750287094403941 0.229725584259969 no 768 0.226540906813565 1089 5724239
SGTC_447 ml7 120 µM 0.749529620160314 0.229957520907508 no 769 0.226769026337451 1150 4216 Selective myosin light chain kinase inhibitor.
SGTC_735 3076-0345 636 µM 0.749486083219811 0.229970855787594 no 770 0.226782141778493 1139 2888990
SGTC_1056 3448-1962 115 µM 0.749048021769649 0.230105053214444 no 771 0.226914130978752 1073 715507
SGTC_3138 9097216 49.47 µM 0.748958902707984 0.230132359652443 no 772 0.226940988116423 1139 25237486
SGTC_1233 0325-0408 14.2 µM 0.748693077744521 0.230213820255126 no 773 0.227021108423521 1098 12874
SGTC_679 0422-0091 41.4 µM 0.748427409830136 0.230295248842641 no 774 0.227101197328742 1159 627384 YHR062C RPP1
SGTC_1896 st058441 89 µM 0.747881984783268 0.230462474903343 no 775 0.227265672418549 1042 688759
SGTC_2009 4012297 12.05 µM 0.747294695042969 0.230642612449532 no 776 0.227442847001458 1076 45595307
SGTC_251 melphalan 456.522 µM 0.745001054361587 0.231346886742926 no 777 0.228135541245468 1202 460612 A DNA alkylator.
SGTC_261 5-fluorouridine 15.376 µM 0.744403722025022 0.231530497400327 no 778 0.228316133955131 1113 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_296 1222-0039 74.9 µM 0.744168328159056 0.231602876116876 no 779 0.228387323129307 1098 5984176
SGTC_2623 humulene 100 µM 0.742994259628868 0.231964066011536 no 780 0.2287425779166 1041 6187145 An anti-inflammatory.
SGTC_740 k014-0057 261 µM 0.742993234374399 0.231964381557354 no 781 0.228742888278097 1126 4012779
SGTC_1179 1021-1431 9.29 µM 0.74251352125448 0.232112050602201 no 782 0.228888131311352 1118 2840958
SGTC_2067 5224629 34.075 µM 0.74185130342864 0.232315985620845 no 783 0.229088716419428 1130 2835000
SGTC_1611 st001856 99.4 µM 0.740224183510745 0.232817492703256 no 784 0.229581987931984 1113 647478
SGTC_1864 st057645 30.4 µM 0.738655146945643 0.233301666634583 no 785 0.230058214139979 1163 688666
SGTC_921 1561-0023 372 µM 0.737077995816759 0.23378890714289 no 786 0.230537459785821 1175 24050882
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.736791379148448 0.233877514187108 no 787 0.2306246132718 1110 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3239 9133757 49.47 µM 0.736289132767413 0.234032827645675 no 788 0.230777379141482 1131 17036923
SGTC_768 0384-0033 77.3 µM 0.736114376691863 0.234086882186635 no 789 0.230830547109069 1097 3965305 YMR134W ERG29
SGTC_418 lividomycin a 100 µM 0.733568127272536 0.234875257172957 no 790 0.231605996134489 1164 72394 An antibiotic.
SGTC_260 nsc-65238 3.989 µM 0.732800372600299 0.235113258575376 no 791 0.231840097013229 1104 3246252
SGTC_3005 9076496 71.4286 µM 0.732790194020291 0.23511641479587 no 792 0.231843201512746 1121 21368410
SGTC_3225 9130819 49.47 µM 0.731948365252796 0.235377533888596 no 793 0.232100042123728 1132 4547121
SGTC_1905 st060207 84.5 µM 0.731855144121428 0.235406459131289 no 794 0.232128493479238 1103 1948547
SGTC_553 k007-0256 45.7 µM 0.731603497191187 0.235484551528638 no 795 0.232205306533328 1174 6287000
SGTC_3254 9136651 49.47 µM 0.730188166047811 0.235924030704977 no 796 0.23263758754894 1148 16454030
SGTC_1310 1188-0297 994 nM 0.72613467898825 0.237185190200774 no 797 0.233878105667114 1119 1588352
SGTC_1668 st014914 51.6 µM 0.724764588200585 0.237612301859054 no 798 0.234298231861637 1163 2839556
SGTC_1451 4152-0210 104 µM 0.723701065887507 0.237944134700184 no 799 0.234624639317556 1151 659563
SGTC_1228 0124-0032 52.5 µM 0.723415101245986 0.238033402722894 no 800 0.234712448096811 1191 X1228
SGTC_1155 4088-0394 48.2 µM 0.722359802345888 0.238362988436742 no 801 0.235036647132243 1135 2326248
SGTC_486 niguldipine 82 µM 0.719867270163975 0.239142435017257 no 802 0.235803360778969 1143 1236 A calcium channel blocker.
SGTC_3227 9130768 49.47 µM 0.719577935611736 0.239233003765756 no 803 0.235892450573761 1160 17720899
SGTC_2243 6634756 200 µM 0.715685768444502 0.240453166620906 no 804 0.237092700177205 1180 885676
SGTC_2822 7994718 71.43 µM 0.714928139105059 0.240691070742897 no 805 0.23732672418418 1111 1018011
SGTC_3099 9120367 49.47 µM 0.712953250814288 0.241311809618456 no 806 0.237937342968332 1215 24824940
SGTC_290 2043-6722 48.1 µM 0.71286210988695 0.241340477648551 no 807 0.237965543751428 1179 773758 YLR208W SEC13
SGTC_1893 st059353 36.1 µM 0.712803710416289 0.241358847951366 no 808 0.237983614651499 1149 3112488
SGTC_594 1487-1584 10.8 µM 0.712616519370036 0.241417736416761 no 809 0.238041543374741 1156 5013332
SGTC_2436 5633522 8.09 µM 0.710971317386849 0.241935636398122 no 810 0.238551005015505 1180 5724242
SGTC_2614 arthonioic acid 13.39 µM 0.71082634348803 0.241981302211875 no 811 0.238595926968715 1134 6710684
SGTC_489 paxilline 115 µM 0.710714552554403 0.242016518804606 no 812 0.238630569931629 1178 105008 A toxic potassium channel blocker.
SGTC_1199 1638-0010 4.46 µM 0.710656773546411 0.242034721547242 no 813 0.238648476183834 1166 3111136
SGTC_3022 9087993 49.47 µM 0.709842130026306 0.242291446477538 no 814 0.238901020042198 1183 17173644
SGTC_1000 4048-0884 8.67 µM 0.70973938880735 0.242323834591066 no 815 0.238932880746008 1155 13040088
SGTC_1847 st056231 15 µM 0.709677610308937 0.242343310757317 no 816 0.23895203976885 1206 5393180
SGTC_2629 bisabolol 100 µM 0.709512788486075 0.242395276306646 no 817 0.239003159156009 1164 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_360 0957-0399 1.01 µM 0.709269135155012 0.242472107162671 no 818 0.239078739038104 1177 6752301 YPR165W RHO1
SGTC_1919 st067113 52.3 µM 0.708477177639609 0.242721925087392 no 819 0.239324489988432 1159 1268243
SGTC_831 k061-1017 217 µM 0.708156038398367 0.242823266093466 no 820 0.239424181452633 1232 1240153
SGTC_2190 6049624 200 µM 0.708065101051117 0.242851967095586 no 821 0.239452415312291 1115 2265554
SGTC_1042 0350-0096 82 µM 0.706971570120132 0.243197243310055 no 822 0.239792072714914 1174 3122515
SGTC_1734 st037168 69.4 µM 0.704369546033904 0.244019883679267 no 823 0.240601333138071 1130 708907
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.704295551166971 0.244043299383407 no 824 0.240624368143227 1137 689007
SGTC_581 0958-0271 211 µM 0.701955888131711 0.244784311280696 no 825 0.241353336743398 1208 4591145
SGTC_1979 st071809 45.3 µM 0.699845906696131 0.245453616314768 no 826 0.242011771058251 1214 4976333
SGTC_2598 perillyl alcohol 100 µM 0.699001988418332 0.245721589806442 no 827 0.242275394093273 1185 10819 An apoptosis inducer.
SGTC_1222 0366-0074 1.18 µM 0.69840081758061 0.245912578282685 no 828 0.242463282608671 1209 286520
SGTC_143 4032-1194 15.74 µM 0.696849539448689 0.246405778106003 no 829 0.242948479825941 1200 1806963
SGTC_3143 9086658 49.47 µM 0.696263062827288 0.246592375361307 no 830 0.243132050350776 1241 25236626
SGTC_2193 5925765 200 µM 0.694954050108276 0.247009132312068 no 831 0.243542049170298 1200 877370
SGTC_1425 4048-4433 7.33 µM 0.69492586539341 0.247018109763812 no 832 0.243550881073232 1250 23734946
SGTC_681 1642-0006 26.6 µM 0.694501377763047 0.247153339523842 no 833 0.243683918543639 1220 4446530
SGTC_46 0329-0187a 2.197 µM 0.693767577672585 0.247387200841746 no 834 0.24391398926683 1210 46494817
SGTC_331 k048-0133 24.5 µM 0.69217520694745 0.247895094254484 no 835 0.244413653302262 1180 6813582
SGTC_1374 2889-5571 141 µM 0.690453395736716 0.248444898880177 no 836 0.244954554003844 1200 2853281
SGTC_2323 6148992 148.28 µM 0.688479524941962 0.24907598920895 no 837 0.245575429856036 1172 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3286 9117135 37.221 µM 0.687415287725954 0.249416603012361 no 838 0.245910533281674 1176 3438150
SGTC_1558 st069300 45.6 µM 0.686986551098688 0.249553891979872 no 839 0.246045601735983 1153 24208000
SGTC_1472 k841-0093 193 µM 0.685993297031831 0.249872103492667 no 840 0.24635866764062 1277 X1472
SGTC_1483 3453-0561 55.9 µM 0.685405717572394 0.250060449271531 no 841 0.246543968549649 1213 4546991
SGTC_1078 idebenone 36.1 µM 0.684487358948334 0.250354975517676 no 842 0.246833734503182 1227 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1257 0669-0121 16 µM 0.684250490551681 0.250430971261084 no 843 0.246908502186581 1248 4307855
SGTC_55 0767-0285 6.563 µM 0.682519544336242 0.25098669082923 no 844 0.247455244358805 1190 3116166
SGTC_414 piperonyl butoxide 100 µM 0.680212214703164 0.251728471512769 no 845 0.248185049631555 1204 5794 A potent inhibitor of cytochrome P450.
SGTC_2695 st077686 51.995 µM 0.67998289710384 0.251802257752859 no 846 0.248257645140682 1209 2876092
SGTC_1855 st056195 39.6 µM 0.679060528279476 0.252099158500535 no 847 0.248549755518976 1190 4028379
SGTC_2270 7924575 90.91 µM 0.678983810150355 0.252123861569295 no 848 0.24857406007827 1207 1262135
SGTC_1569 carminic acid 40.6 µM 0.678976484824147 0.252126220374993 no 849 0.248576380832272 1226 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1884 5633444 25 µM 0.677881059490885 0.252479085891776 no 850 0.248923555021207 1232 5724239
SGTC_3169 9102970 49.47 µM 0.677594866443273 0.252571319111914 no 851 0.249014300955094 1280 17027839
SGTC_3103 9120822 49.47 µM 0.677462706248662 0.252613917193207 no 852 0.249056212177149 1286 17141819
SGTC_3329 9141233 27.5565 µM 0.675675897785295 0.253190215364204 no 853 0.249623220912866 1221 4909101 YNL103W MET4
SGTC_910 3454-3003 490 µM 0.675675648499468 0.25319029581441 no 854 0.249623300066661 1192 820824
SGTC_891 0929-0073 133 µM 0.675402307516594 0.253278517254171 no 855 0.249710099929982 1237 5603632
SGTC_2572 astragaloside iv 100 µM 0.674490759476595 0.253572838288078 no 856 0.249999679274407 1243 45006101 An anti-inflammatory agent.
SGTC_519 k048-0011 62.8 µM 0.673258770436385 0.25397090878117 no 857 0.250391338868836 1230 6836379
SGTC_2264 7948757 110.76 µM 0.672995687598245 0.254055956482033 no 858 0.250475017219367 1221 2971411
SGTC_123 0083-0120 66.675 µM 0.671928915092943 0.254400968788888 no 859 0.250814475714422 1185 16001701
SGTC_1143 3454-2408 5.08 µM 0.670565085185152 0.254842411873677 no 860 0.251248815561828 1194 X1143
SGTC_390 dec-rvkr-cmk 16.7 µM 0.669076514417272 0.255324688195949 no 861 0.25172333528641 1282 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_398 bronopol 33.3 µM 0.66763140552353 0.255793339446326 no 862 0.252184452775449 1181 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1953 st076800 12.1 µM 0.667021428695085 0.255991290646132 no 863 0.252379222927323 1210 297591
SGTC_1214 0358-0031 63.7 µM 0.666685388706467 0.256100377312666 no 864 0.252486556865973 1293 4301366
SGTC_81 0411-0046 9.971 µM 0.664291268727436 0.256878267377291 no 865 0.253251954113856 1142 12925265
SGTC_209 4077-0173 175.592 µM 0.663989456846346 0.256976418359583 no 866 0.253348529525109 1191 15993494
SGTC_1321 1326-2144 215 µM 0.662293609194145 0.25752828048186 no 867 0.25389153588798 1231 3513030
SGTC_2144 5628481 200 µM 0.660586174770685 0.258084534415097 no 868 0.254438868793012 1238 2818399
SGTC_571 k831-0106 44.2 µM 0.660440295529607 0.25813208833626 no 869 0.254485660302392 1242 4783639
SGTC_2561 acetosyringone 100 µM 0.660061814177784 0.258255487403266 no 870 0.254607081143719 1244 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1346 1488-2224 62.4 µM 0.659695571215341 0.258374925399856 no 871 0.254724604661405 1260 3722427
SGTC_982 1491-0518 27.5 µM 0.658897647691656 0.258635240763544 no 872 0.254980748255089 1228 3091256
SGTC_2294 7971431 200 µM 0.658890413592201 0.258637601444309 no 873 0.254983071109262 1205 5741572
SGTC_1777 st045864 34.765 µM 0.65888533198782 0.258639259714844 no 874 0.254984702808399 1258 4691462
SGTC_2566 crystal violet carbinol 226 nM 0.658813432770781 0.258662723042939 no 875 0.255007790175459 1199 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_771 0250-0039 27.3 µM 0.657671416820803 0.259035552062325 no 876 0.255374646486347 1245 3005115
SGTC_2332 7982454 138.89 µM 0.65750484122932 0.259089956491447 no 877 0.255428179556772 1254 2981748
SGTC_217 ketoconazole 989 nM 0.657144478955415 0.259207672842046 no 878 0.255544010697964 1203 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2704 st078022 71.1 µM 0.654794229815594 0.259976085428398 no 879 0.256300123109167 1283 54697681
SGTC_2012 4023501 200 µM 0.653632938700282 0.260356202064396 no 880 0.256674158874967 1231 3477460
SGTC_1389 3405-0187 19 µM 0.65351488839098 0.260394858604316 no 881 0.256712197151115 1221 799890
SGTC_268 camptothecin 39.6153 µM 0.652989017814287 0.260567095138809 no 882 0.25688167928791 1287 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1629 st005085 44.9 µM 0.651908285897293 0.260921247486787 no 883 0.257230169661948 1256 24207091
SGTC_1904 st060225 78 µM 0.651065551725738 0.261197580426267 no 884 0.257502086266701 1245 66595
SGTC_442 cape 100 µM 0.650727563519744 0.261308449158354 no 885 0.257611183474673 1256 5281787
SGTC_712 r015-0009 80.6 µM 0.650657428718805 0.261331458186037 no 886 0.257633824877694 1239 6813872 YLR060W FRS1
SGTC_810 3825-7150 143 µM 0.650448503500623 0.261400006162115 no 887 0.257701277689233 1298 22330411 YGL099W LSG1
SGTC_2984 9022109 38.96 µM 0.650280322056899 0.261455192889168 no 888 0.257755582778643 1313 6459207
SGTC_3019 9081971 49.47 µM 0.647976175346849 0.262211873027383 no 889 0.25850017989835 1314 16451803
SGTC_1702 st027038 51 µM 0.64725171780132 0.26245001599641 no 890 0.25873452216014 1278 5521182
SGTC_1477 0139-0234 16 µM 0.64716896833745 0.262477224363121 no 891 0.258761296350785 1275 620880
SGTC_2397 5161689 200 µM 0.644986647275958 0.263195301408931 no 892 0.259467919418744 1342 2259942
SGTC_3272 9137413 49.47 µM 0.644858946304356 0.263237351553534 no 893 0.259509299106684 1221 17614870
SGTC_293 4049-0273 38.5 µM 0.644555302487034 0.263337350995869 no 894 0.259607704261336 1202 1380311
SGTC_1202 1988-0068 29.6 µM 0.643910786007703 0.263549674773463 no 895 0.259816643553205 1215 2850480
SGTC_2047 4141938 200 µM 0.643563778861088 0.263664025890088 no 896 0.259929172218817 1270 3807862
SGTC_1727 st034309 9.9045 µM 0.642905715248508 0.263880950593154 no 897 0.260142640357589 1327 870305
SGTC_1343 1487-0095 224 µM 0.642201645506517 0.264113141504892 no 898 0.260371132370472 1275 4560101 YGL055W OLE1
SGTC_2470 5664817 21.68 µM 0.641048630326001 0.264493612087666 no 899 0.260745543964728 1308 2859561
SGTC_646 4092-0839 27.3 µM 0.639901642258936 0.264872370375358 no 900 0.261118273089146 1323 877796
SGTC_603 3794-0023 45.9 µM 0.639464258843657 0.265016875658264 no 901 0.261260478776837 1274 3802260
SGTC_919 tnp00227 403.569 nM 0.638372528072846 0.265377742714982 no 902 0.261615604778118 1305 1269246 A methoxyflavone. YNL221C POP1
SGTC_2961 9083290 32.55 µM 0.637573141537917 0.265642134666671 no 903 0.261875791981307 1277 17741490
SGTC_1991 st073000 8.92 µM 0.637188865798708 0.265769278917501 no 904 0.262000914643911 1352 4301969 YIL048W NEO1
SGTC_1204 4049-0315 18.3 µM 0.63689171408389 0.265867617829131 no 905 0.262097690169916 1357 588402
SGTC_3057 9095946 49.47 µM 0.63656635150784 0.265975313942478 no 906 0.262203674336666 1305 24540043
SGTC_2643 anethole 100 µM 0.636486786403206 0.266001653623929 no 907 0.262229595352009 1273 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_160 3453-0671 289.699 µM 0.636109779870528 0.266126477955948 no 908 0.262352435785695 1236 5322268
SGTC_2279 7948423 32.93 µM 0.633877063561925 0.26686632279281 no 909 0.263080527643715 1327 1247112
SGTC_1386 3228-0095 33.8 µM 0.633275421378964 0.267065863760197 no 910 0.26327690044861 1298 870181
SGTC_306 1672-3436 11.6 µM 0.632882843123122 0.267196107078279 no 911 0.263405076249287 1313 6797378
SGTC_2261 9010538 184.68 µM 0.632642253571409 0.267275941862427 no 912 0.263483643866569 1227 6457250
SGTC_3063 1327-0034 4 µM 0.629863836904218 0.268198774595089 no 913 0.264391837465007 1214 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_953 1188-0045 9.7 µM 0.629654992587318 0.268268205586607 no 914 0.264460167682013 1311 6144426
SGTC_78 0336-0123 156.75 µM 0.629355482194106 0.268367794598959 no 915 0.264558177941459 1229 6765896
SGTC_499 genistein 192 µM 0.628476547575481 0.26866015296315 no 916 0.264845902688541 1306 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1554 st069299 38.7 µM 0.628211325719153 0.268748404630258 no 917 0.264932755953329 1290 24207999
SGTC_1071 trifluoperazine 6.31 µM 0.627906091457598 0.268849988309342 no 918 0.265032730152678 1342 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_850 0388-0143 75.9 µM 0.627137631032103 0.269105821615115 no 919 0.265284510904052 1275 67273
SGTC_867 0518-0118 155 µM 0.626088304047649 0.269455357267323 no 920 0.265628511642439 1333 6848158
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.62493739131528 0.269838993106355 no 921 0.266006075177291 1294 97141
SGTC_3213 9129884 49.47 µM 0.622901181738859 0.270518395766071 no 922 0.266674730711507 1220 17190742
SGTC_544 k015-0020 52.4 µM 0.622704934422277 0.270583920865138 no 923 0.266739219753923 1311 3008304
SGTC_136 0097-0015 404.482 µM 0.622067995523242 0.270796643268946 no 924 0.266948579224958 1303 4861337
SGTC_2429 5902844 64.44 µM 0.621547881007577 0.270970411009772 no 925 0.267119600491344 1331 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_605 1315-0399 119 µM 0.6214864439753 0.270990940497888 no 926 0.267139805539056 1350 24020461
SGTC_2541 muurolladie-3-one 83.07 µM 0.621423339111308 0.271012028108018 no 927 0.267160559896585 1318 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_521 r062-0005 13.8 µM 0.620093913317904 0.271456469512672 no 928 0.26759797961108 1253 2832033
SGTC_1166 k206-0078 225 µM 0.619527806672698 0.271645835243982 no 929 0.267784354688229 1303 5404595
SGTC_1842 st055362 61.2 µM 0.618567518582683 0.271967207128687 no 930 0.268100652677103 1320 676032
SGTC_2366 9070441 60.58 µM 0.616956105249473 0.272506910407622 no 931 0.268631839340543 1289 6837235
SGTC_1501 4491-0275 38.4 µM 0.616219598290408 0.272753762259372 no 932 0.268874797646453 1299 5104718
SGTC_1828 st055811 49 µM 0.61598481227368 0.272832477787502 no 933 0.268952271850806 1281 5877589
SGTC_2797 7859098 81.82 µM 0.61518755073378 0.27309985572636 no 934 0.269215434178498 1335 972681
SGTC_2402 5553605 200 µM 0.613284064458854 0.273738753424328 no 935 0.269844264162509 1376 6758546
SGTC_201 4262-0159 12.803 µM 0.613092697094456 0.273803026003926 no 936 0.269907524365406 1297 1341029
SGTC_1045 1348-1485 165 µM 0.612638706907977 0.273955532843517 no 937 0.270057629336886 1323 6810614
SGTC_1666 st014829 29 µM 0.612584382105121 0.273973784737497 no 938 0.270075593806766 1333 3858230
SGTC_2722 naftopidil 47.16 µM 0.610881225372693 0.274546311132374 no 939 0.270639107474995 1333 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2606 farnesol 9.78 µM 0.61071977867184 0.274600613026197 no 940 0.270692554870147 1371 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2081 5214970 32.255 µM 0.609013392520963 0.275174872268813 no 941 0.271257780963099 1308 2063512
SGTC_2892 9047358 58.44 µM 0.608464949610461 0.275359568176003 no 942 0.271439572923957 1293 6466771
SGTC_1928 4'-methoxychalcone 40.3 µM 0.607776407999065 0.275591530636271 no 943 0.2716678891966 1402 641818
SGTC_381 3461-2219 42.7 µM 0.607134241844524 0.275807956251406 no 944 0.271880913774439 1331 2883159
SGTC_3352 9151559 45.5865 µM 0.606067886245962 0.2761675284165 no 945 0.272234837399924 1284 17159339
SGTC_2729 fluphenazine 10.66 µM 0.605855197950926 0.276239273835523 no 946 0.272305456063111 1256 3372 An atypical antipsychotic.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.605707018612187 0.27628926407302 no 947 0.27235466126656 1323 442882
SGTC_790 1575-0012 79.1 µM 0.604894082789293 0.276563597547784 no 948 0.272624687533387 1364 378741 YLR208W SEC13
SGTC_2306 7482397 179.52 µM 0.604837158262508 0.276582812310501 no 949 0.272643600666533 1403 891448
SGTC_404 fumagillin 50 µM 0.604507874933655 0.276693974093319 no 950 0.272753017593102 1344 12015870 A methionine aminopeptidase binder.
SGTC_955 1216-0110 33 µM 0.604415368114351 0.276725207134731 no 951 0.272783760426431 1287 3619719
SGTC_707 0865-0008 204 µM 0.603461272108253 0.277047438941614 no 952 0.27310093584673 1368 723043
SGTC_2299 7976368 114.88 µM 0.603222090006807 0.277128247937954 no 953 0.273180477121448 1391 2979718
SGTC_450 aminopyrene 156 nM 0.60254493346164 0.277357091552462 no 954 0.27340573135024 1337 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1007 4101-0031 70 µM 0.599780799280852 0.278292182069529 no 955 0.274326165625619 1335 1146276
SGTC_852 0418-0143 439 µM 0.599460780033077 0.278400541905278 no 956 0.274432828170181 1360 5369229
SGTC_3295 9122362 53.5725 µM 0.599308211336111 0.278452209531644 no 957 0.274483686582655 1337 4730473
SGTC_1922 5578187 25 µM 0.599257197511942 0.278469486484696 no 958 0.274500692957165 1420 1350412
SGTC_371 0195-0006 7.36 µM 0.598438054729848 0.278746978697667 no 959 0.274773840094605 1263 3928593
SGTC_1053 3366-3204 134 µM 0.598174705502122 0.278836219274986 no 960 0.274861683629214 1289 3632071 YPR165W RHO1
SGTC_689 0833-0039 98 µM 0.596993078214314 0.279236805790605 no 961 0.275256000962828 1347 5374726
SGTC_1975 st070967 30.8 µM 0.596862863134634 0.279280967444397 no 962 0.275299471678466 1348 261391
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.59608437237482 0.279545058634659 no 963 0.275559431785348 1312 5355888
SGTC_1981 st071826 47 µM 0.594806636036653 0.27997877395671 no 964 0.275986365622943 1312 11838600
SGTC_2858 9025781 8.96 µM 0.59468366317002 0.280020533119078 no 965 0.276027472042564 1360 4894980 YPL153C RAD53
SGTC_659 k018-0002 107 µM 0.591848208951891 0.28098423399876 no 966 0.276976118735876 1330 6797879 YHR007C ERG11
SGTC_3109 9122853 49.47 µM 0.591313687260032 0.281166084111972 no 967 0.277155130184588 1422 1234709
SGTC_2001 4023502 57.655 µM 0.591045086528062 0.281257486465147 no 968 0.277245106002135 1383 108941 YCR052W RSC6
SGTC_1268 0828-0275 2.46 µM 0.590516714216624 0.281437328547921 no 969 0.277422141735146 1391 745337
SGTC_1084 voriconazole 435 nM 0.590049583856709 0.281596371907407 no 970 0.277578703833341 1361 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3026 9090633 49.47 µM 0.589316869875975 0.281845925512434 no 971 0.277824365124083 1319 25236842
SGTC_2214 7179297 48.276 µM 0.589095353500859 0.281921392310663 no 972 0.277898655102266 1390 769744
SGTC_1745 st081495 74 µM 0.588383467825196 0.282163985340471 no 973 0.278137465933351 1315 13842402 YBL026W LSM2
SGTC_3014 9081533 49.47 µM 0.588070063451743 0.282270817647363 no 974 0.2782426330198 1392 21367265
SGTC_3350 9150499 3.57 µM 0.587395514924593 0.282500821657051 no 975 0.278469052674605 1309 4910996 YPR165W RHO1
SGTC_875 0709-0210 25.7 µM 0.587230067839888 0.282557248693078 no 976 0.278524600519657 1379 6251364
SGTC_1467 k284-1082 293 µM 0.586198585225652 0.282909166134393 no 977 0.278871036161925 1407 3334705
SGTC_1565 sinapyl alcohol 95.1 µM 0.586074852429382 0.282951394968139 no 978 0.278912607365738 1316 5280507 A phenol propionate derived from cinnamic acid.
SGTC_130 0136-0219 337.655 µM 0.585497966179247 0.283148320730251 no 979 0.279106466872731 1337 234244
SGTC_2328 6201408 200 µM 0.584662605576719 0.28343359574304 no 980 0.279387301355965 1340 2890418
SGTC_1131 3454-3128 32.3 µM 0.583576308087757 0.283804771457003 no 981 0.279752701872794 1464 710982
SGTC_701 4424-0219 185 µM 0.580371997630709 0.284901002157304 no 982 0.280831892291576 1403 2911779
SGTC_2645 abamectin 100 µM 0.580343407812984 0.284910792140477 no 983 0.280841530204332 1343 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_19 0279-0214 38.434 µM 0.579860621600335 0.285076136378242 no 984 0.281004306398982 1402 3566274 YBR002C RER2
SGTC_2333 9017922 200 µM 0.578936205645641 0.285392857211212 no 985 0.281316109630316 1466 3163164
SGTC_3310 9130229 44.1445 µM 0.578596700681456 0.28550921952073 no 986 0.281430665738283 1427 7761258
SGTC_1415 3966-0071 78.1 µM 0.574890325357833 0.286781013585578 no 987 0.282682736690565 1369 2893185
SGTC_17 0960-0276 49.807 µM 0.574462311727165 0.286928053632676 no 988 0.282827498553619 1369 6821114
SGTC_821 1114-0266 29.2 µM 0.573399706057121 0.287293256123525 no 989 0.283187044646851 1364 3123235
SGTC_2701 st077767 14.721 µM 0.572812345027707 0.287495218121943 no 990 0.283385879753462 1367 5721188
SGTC_2374 9071832 200 µM 0.572430760165778 0.287626460682618 no 991 0.283515090790057 1342 17381698
SGTC_1120 ficusin 1.78878 µM 0.572297149920644 0.287672421375192 no 992 0.283560340133526 1491 6199 A DNA cross-linker.
SGTC_1258 0671-0043 57.1 µM 0.571750590797153 0.287860468803712 no 993 0.283745477540867 1349 4298767
SGTC_617 3770-0098 35 µM 0.570107078602076 0.288426279959987 no 994 0.28430253719716 1392 5962639
SGTC_737 1950-0117 57.9 µM 0.569822627187509 0.28852426110404 no 995 0.284399003520059 1360 5393513
SGTC_2074 5212007 75.395 µM 0.569653722955513 0.288582448688427 no 996 0.284456291598769 1336 758611
SGTC_1439 4092-1168 46 µM 0.569470576125905 0.288645549100833 no 997 0.284518416638471 1383 2886240
SGTC_2830 7992007 71.43 µM 0.567963801975301 0.28916493137411 no 998 0.285029773703071 1399 1952075
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.567664233175561 0.289268244528819 no 999 0.285131491185626 1376 4330530
SGTC_2256 7954252 200 µM 0.567619326902783 0.289283732979565 no 1000 0.285146740436244 1333 2972920
SGTC_1787 fluconazole 80 µM 0.567599505766772 0.28929056953574 no 1001 0.285153471411775 1298 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2622 2-methoxyxanthone 59.94 µM 0.565121532805697 0.290145850708277 no 1002 0.285995551666962 1470 71034 A hepatoprotective.
SGTC_1561 5-methoxyflavone 52.9 µM 0.56402435555751 0.290524923426411 no 1003 0.286368778419493 1352 94525
SGTC_754 3474-0146 171 µM 0.56373996077081 0.290623219111978 no 1004 0.28646555870266 1318 24762078
SGTC_2210 7115885 190.385 µM 0.562505699569709 0.291049998358728 no 1005 0.286885760730732 1387 2927039
SGTC_1526 st051518 75 µM 0.562076162632549 0.291198591031248 no 1006 0.287032064292597 1397 673993
SGTC_2975 9084847 53.72 µM 0.557876493576337 0.292653274050756 no 1007 0.288464362001741 1426 27211724
SGTC_1959 st077091 55.8 µM 0.555724117269827 0.29340012103569 no 1008 0.28919973350135 1396 821356 YKL052C ASK1
SGTC_1909 st060837 51.5 µM 0.555664271481576 0.293420899368845 no 1009 0.289220192739129 1366 678937
SGTC_1337 1486-1011 40.3 µM 0.555597351874767 0.293444134524393 no 1010 0.289243071080418 1392 X1337
SGTC_3123 9126162 49.47 µM 0.554862277343827 0.293699415822039 no 1011 0.289494432865058 1440 25239884
SGTC_930 2810-3379 265 µM 0.554705519101825 0.293753869102355 no 1012 0.289548050264825 1549 1015764
SGTC_627 1391-0720 175 µM 0.554704705032242 0.293754151898781 no 1013 0.289548328720372 1384 997839
SGTC_1699 st031318 29.054 µM 0.554078707235083 0.293971652092588 no 1014 0.289762490824833 1458 5340658
SGTC_1652 st011932 78 µM 0.553465117669327 0.294184913334649 no 1015 0.289972480011086 1433 1551076
SGTC_122 0236-0016 402.397 µM 0.55329601405126 0.294243700115929 no 1016 0.290030365000011 1428 6808838
SGTC_421 streptovitacin 30 mM 0.552723652207086 0.294442714886936 no 1017 0.29022632741991 1429 91467 include heat shock
SGTC_319 1348-1596 45.5 µM 0.552402978763704 0.29455424274788 no 1018 0.290336145112411 1495 5380505
SGTC_2981 9013952 38.96 µM 0.550934737554153 0.295065134988752 no 1019 0.290839206722135 1304 2996344
SGTC_455 paf C-16 10 µM 0.549430996777335 0.295588802391531 no 1020 0.291354853473802 1400 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1125 tnp00248 1.32998 µM 0.548899691880567 0.295773927771744 no 1021 0.291537144821901 1513 24207736
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.547065546114335 0.296413417871525 no 1022 0.292166850808783 1504 165506
SGTC_2380 9035439 200 µM 0.546444713897445 0.296630019640393 no 1023 0.292380140593504 1497 6462575
SGTC_2544 sphondin 68.51 µM 0.545333171652694 0.29701800591091 no 1024 0.292762196825285 1453 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_954 1189-0853 2.85 µM 0.543688413693166 0.297592537740466 no 1025 0.293327953397429 1396 2828194
SGTC_2777 climbazole 1.536 µM 0.543630124755781 0.297612908003705 no 1026 0.293348012661355 1433 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_213 1246-0773 967 nM 0.543020385440988 0.297826032034263 no 1027 0.293557883398227 1432 6251622
SGTC_2851 9015922 71.43 µM 0.542155853917657 0.298128333606553 no 1028 0.293855572089321 1474 2996893
SGTC_263 alizarin 107.927 µM 0.541456657640782 0.298372924437816 no 1029 0.294096432111158 1454 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_628 1636-0253 16 µM 0.541441574899622 0.298378201645201 no 1030 0.294101628838211 1464 4456143
SGTC_2272 7805186 180 µM 0.54137002507359 0.298403236351785 no 1031 0.294126281759918 1408 2956062 YPR165W RHO1
SGTC_82 0054-0107 293.755 µM 0.540117997523599 0.298841465315159 no 1032 0.294557829841785 1453 3104697
SGTC_2235 salicylic acid 500 µM 0.539306488334448 0.299125662156974 no 1033 0.294837696286248 1442 338 A COX inhibitor and kinase inhibitor.
SGTC_2312 7706453 155.7 µM 0.537641896095649 0.299708998892361 no 1034 0.295412150058373 1425 976098
SGTC_8 0354-0001 70 µM 0.537224069349342 0.299855502213799 no 1035 0.295556423618465 1460 4993152
SGTC_966 1300-0360 30.2 µM 0.536632846519335 0.300062859080475 no 1036 0.29576062534427 1432 70588
SGTC_1512 0259-0544 12.2 µM 0.53504801352826 0.300619019993436 no 1037 0.296308328372801 1447 18476
SGTC_1765 st044815 90.4 µM 0.534751059924656 0.300723280818706 no 1038 0.296411004395132 1363 645695
SGTC_1478 0453-0656 35.7 µM 0.534148652446399 0.300934837037537 no 1039 0.296619345616334 1444 5258496
SGTC_2448 5185112 27.17 µM 0.533714397040893 0.301087382453214 no 1040 0.296769573426673 1402 5718189
SGTC_798 1287-0182 476 µM 0.532172134566951 0.301629430474251 no 1041 0.297303390323198 1520 1649755
SGTC_1556 plumbagin 1.48 µM 0.529738849634042 0.302485531071073 no 1042 0.29814650406171 1389 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1407 3909-7909 12.3 µM 0.527312633628242 0.30334022757144 no 1043 0.298988251221308 1420 4411780
SGTC_3089 9117425 49.47 µM 0.527295555266932 0.303346247683877 no 1044 0.29899418018182 1376 9401657
SGTC_1396 3511-0007 98.6 µM 0.527284140260508 0.303350271496778 no 1045 0.298998143069683 1416 X1396
SGTC_1712 st032288 53.4 µM 0.527199544882552 0.30338009228235 no 1046 0.299027512346371 1413 2883011
SGTC_1189 1431-2119 7.28 µM 0.526858394765041 0.30350036467884 no 1047 0.2991459639304 1449 3107275
SGTC_574 1315-0397 40 µM 0.525474201080252 0.303988580195903 no 1048 0.299626791630736 1433 6794277
SGTC_785 1270-0111 65.3 µM 0.522890616306327 0.304900765248229 no 1049 0.300525187519362 1418 6741994
SGTC_1450 4112-4260 37.6 µM 0.522510821318846 0.305034961753908 no 1050 0.300657356999861 1475 1633175
SGTC_531 3788-1495 174 µM 0.522134007284878 0.305168130886395 no 1051 0.300788515025318 1441 2896655
SGTC_2208 7283366 200 µM 0.521535435175065 0.305379724153848 no 1052 0.300996913651942 1518 898663
SGTC_1624 st003710 6.25 µM 0.520768438082562 0.305650950158165 no 1053 0.301264046151688 1532 24207033
SGTC_886 0866-0150 153 µM 0.520406915771284 0.30577882890733 no 1054 0.301389995453127 1554 271463
SGTC_3208 9114115 49.47 µM 0.518696313968717 0.306384229059178 no 1055 0.301986266271101 1377 650895
SGTC_1715 st032160 10.2275 µM 0.518306643379505 0.306522211643679 no 1056 0.302122169259369 1483 5289825
SGTC_840 0245-0196 390 µM 0.518015349432968 0.30662537692116 no 1057 0.302223779968864 1532 3827528
SGTC_3156 9099931 49.47 µM 0.517191631718891 0.306917189432733 no 1058 0.302511196545694 1513 18111053
SGTC_2934 9036370 36.88 µM 0.515630669440877 0.307470515823771 no 1059 0.303056192793063 1563 6462800
SGTC_158 k038-0087 26.446 µM 0.515534026357717 0.307504788070444 no 1060 0.303089949311077 1496 X158
SGTC_1726 st035556 14.5795 µM 0.513493496074061 0.308228807147638 no 1061 0.303803079594927 1548 5919439
SGTC_2062 5245942 200 µM 0.513371075824869 0.308272267958871 no 1062 0.303845887162576 1491 1376160
SGTC_987 1497-1013 404 µM 0.512324077164624 0.30864407610191 no 1063 0.304212108554331 1459 1676435
SGTC_2950 9072895 21.46 µM 0.511365968797848 0.30898448969799 no 1064 0.304547409899092 1410 17332245
SGTC_2903 5923464 63.88 µM 0.510704051262271 0.309219763283647 no 1065 0.304779151750369 1479 2876576
SGTC_1571 st070080 73.4 µM 0.509816367342232 0.309535406659702 no 1066 0.305090058938017 1564 4315245
SGTC_2180 6301957 200 µM 0.509566681850552 0.309624215367787 no 1067 0.305177535494569 1451 845462
SGTC_1618 st003135 44.5 µM 0.507454671586148 0.3103758642914 no 1068 0.305917916761933 1454 1270615
SGTC_1109 tnp00067 928.257 nM 0.506970394395488 0.310548326808635 no 1069 0.306087795798383 1449 676295
SGTC_3029 9088683 49.47 µM 0.506320756541907 0.310779743560862 no 1070 0.306315747014906 1467 25236615
SGTC_849 0386-0493 241 µM 0.505866129220312 0.310941737373673 no 1071 0.306475315656398 1428 726119
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.505019371037172 0.311243553788962 no 1072 0.306772615265017 1482 6857784
SGTC_1424 4048-1941 275 µM 0.502836433540441 0.312022219800488 no 1073 0.307539637950346 1567 X1424
SGTC_120 rhodamine 6G 52.259 µM 0.5019389023774 0.312342618290921 no 1074 0.307855249630944 1453 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2585 alliin 100 µM 0.501910751614957 0.312352669778588 no 1075 0.307865150986177 1591 87310 A garlic compound which reacts with lipids.
SGTC_1720 st037298 9.481 µM 0.501702608501085 0.31242699351731 no 1076 0.307938364673146 1465 597396
SGTC_720 r052-1644 49.9 µM 0.499431763514224 0.313238362067658 no 1077 0.308737623501786 1475 1422863 YOR257W CDC31
SGTC_3276 9139060 49.47 µM 0.498410099230694 0.313603696157107 no 1078 0.309097509969176 1509 4870619
SGTC_50 0929-0078 56.389 µM 0.496418752235989 0.314316301822974 no 1079 0.309799498704594 1545 1377751
SGTC_2853 9015042 58.44 µM 0.495974814907947 0.314475259776439 no 1080 0.309956090006089 1402 6457456
SGTC_349 k015-0014 24 µM 0.495940985521636 0.314487374271096 no 1081 0.309968024157896 1450 2196908
SGTC_3148 9097893 49.47 µM 0.495191439471864 0.314755842178217 no 1082 0.31023249639179 1362 17174100
SGTC_641 4092-0595 30 µM 0.495102019550987 0.31478787661074 no 1083 0.31026405416104 1520 786260
SGTC_75 0159-0059 199.013 µM 0.494709903955458 0.314928367362457 no 1084 0.310402454734869 1584 5377270
SGTC_847 0342-0274 5.54 µM 0.494654357382671 0.314948271261416 no 1085 0.310422062547289 1569 18097
SGTC_777 1315-0167 517 µM 0.492742547705793 0.315633653679503 no 1086 0.311097255035456 1450 4221767
SGTC_2766 oltipraz 83.91 µM 0.492205213294981 0.315826402034152 no 1087 0.311287139695575 1567 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1880 MG-132 525 µM 0.491095438256322 0.31622465029177 no 1088 0.311679473889597 1555 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2206 7254556 146.969 µM 0.490157918565676 0.316561250088706 no 1089 0.31201107803725 1531 4398905
SGTC_1653 st012112 65 µM 0.489704482174209 0.316724102919913 no 1090 0.312171514848886 1531 720429
SGTC_361 000s-0510 1.45 µM 0.489199347379023 0.31690556519741 no 1091 0.312350285764488 1500 660
SGTC_505 gw-5074 63.9 µM 0.48887933681121 0.317020547104633 no 1092 0.312463562718907 1571 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2683 piperine 63.03 µM 0.488547991146187 0.317139620408493 no 1093 0.312580870733192 1483 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2394 5221648 200 µM 0.48789013336327 0.317376086126692 no 1094 0.312813831789496 1652 788586
SGTC_2926 9010726 65.15 µM 0.487658765190211 0.317459268699429 no 1095 0.312895781827826 1446 2994293
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.487505616836248 0.317514334386246 no 1096 0.31295003168474 1459 23665772 A membrane-active detergent.
SGTC_2703 st077852 53.4 µM 0.483859688527288 0.318826446498996 no 1097 0.314242725457622 1528 6281836
SGTC_2247 cerulenin 830 nM 0.48265177540252 0.319261657755042 no 1098 0.314671504969417 1568 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_611 3453-1652 23.7 µM 0.481950054962215 0.319514602186382 no 1099 0.314920713359941 1566 1560575
SGTC_2302 7771753 200 µM 0.48101084565972 0.319853284063274 no 1100 0.315254395238692 1449 2203047
SGTC_3274 9138298 49.47 µM 0.479716337025015 0.320320334215209 no 1101 0.315714554795797 1479 17015756
SGTC_460 trequinsin 123 µM 0.478834339103626 0.320638716393654 no 1102 0.316028242750291 1521 5537 A vasodilator.
SGTC_1891 st059073 26.2 µM 0.477888170117814 0.320980409700853 no 1103 0.316364900851237 1657 688754
SGTC_1943 st076331 65.2 µM 0.477715072909083 0.32104293731935 no 1104 0.316426507365006 1543 24208415
SGTC_1038 k292-0204 154 µM 0.477682877857594 0.321054567644344 no 1105 0.316437966372156 1461 4454212
SGTC_2164 5685496 200 µM 0.477650513323418 0.321066259371175 no 1106 0.316449485879969 1547 759046
SGTC_2644 guaiazulene 100 µM 0.476620893029267 0.321438303476954 no 1107 0.316816051503466 1556 3515 A coloring agent.
SGTC_1198 1612-1005 86.7 µM 0.475991364832579 0.321665866183175 no 1108 0.317040264916372 1592 6998509
SGTC_1802 st050112 57.9 µM 0.474975162107122 0.322033345706348 no 1109 0.317402338480767 1505 4662563
SGTC_105 0111-0055 734.78 µM 0.474659667427681 0.322147470412327 no 1110 0.317514784974005 1505 5179370
SGTC_3113 9123498 49.47 µM 0.473257307746702 0.322654952431591 no 1111 0.318014808256566 1561 8897275
SGTC_1405 3909-7894 12 µM 0.471315055934254 0.32335835489149 no 1112 0.318707882781431 1604 7104060
SGTC_990 3985-0011 41.3 µM 0.468413536573636 0.324410340516399 no 1113 0.319744444796422 1523 5399565 YGL099W LSG1
SGTC_2364 9055074 200 µM 0.467313561946511 0.324809518595199 no 1114 0.320137777437699 1475 6470630
SGTC_2925 9010536 32.5 µM 0.464911520801618 0.325681912538699 no 1115 0.320997409927033 1624 2994177
SGTC_2601 securinine 100 µM 0.464694167039524 0.325760900160708 no 1116 0.32107524303474 1502 442872 A GABA receptor antagonist.
SGTC_985 1493-0307 8.71 µM 0.464018155994612 0.326006616494301 no 1117 0.321317368863366 1629 3278274
SGTC_661 1304-0007 33.6 µM 0.463695511812403 0.326123917774421 no 1118 0.321432956614914 1509 3117130
SGTC_470 aa-861 153 µM 0.463406154941903 0.326229131676379 no 1119 0.321536633848377 1499 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2126 5251174 33.877 µM 0.463326355543364 0.326258150203779 no 1120 0.321565228602841 1704 790722
SGTC_2108 5365811 200 µM 0.462917146531803 0.326406972897849 no 1121 0.32171187828666 1592 780283
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.462778257898078 0.326457490729388 no 1122 0.321761658614576 1455 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2353 9059630 146.67 µM 0.46259754041473 0.326523227694328 no 1123 0.321826435987951 1590 4779114
SGTC_321 4534-3890 65.3 µM 0.462530291210416 0.326547691332741 no 1124 0.321850542547049 1598 699746
SGTC_279 1273-0055 2.93 µM 0.461933519906637 0.326764815009028 no 1125 0.322064497662496 1592 2847562
SGTC_747 3448-8087 38.7 µM 0.459332046817505 0.327711995210104 no 1126 0.322997868976646 1521 5168703
SGTC_2356 9061756 188.97 µM 0.45816140511905 0.328138580984795 no 1127 0.323418242845846 1588 20104043
SGTC_65 0798-0905 34.986 µM 0.457924127540985 0.328225073083122 no 1128 0.323503476004851 1735 3602145
SGTC_2185 6113692 200 µM 0.457858701119799 0.328248923852703 no 1129 0.323526979646279 1546 874150
SGTC_1216 1165-0504 9.65 µM 0.456893030352677 0.328601034134064 no 1130 0.323873966901265 1616 6304004
SGTC_984 1492-0255 2.91 µM 0.456317369001218 0.328811008642281 no 1131 0.324080887855757 1577 1585198
SGTC_1531 st059297 52.4 µM 0.455839136776294 0.328985486636947 no 1132 0.324252829340438 1545 7566702
SGTC_396 dithiazanine 1.25 µM 0.455373035074539 0.329155574801307 no 1133 0.324420445543655 1496 10578 An antihelmenthic.
SGTC_2778 tioconazole 65.09 nM 0.455097944550913 0.329255976451136 no 1134 0.32451938835391 1497 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_760 0568-0725 82.9 µM 0.454468444306987 0.329485775738669 no 1135 0.324745849596911 1652 3916171
SGTC_772 k072-0172 35.3 µM 0.45438585055671 0.329515931398197 no 1136 0.324775567315862 1444 5861980
SGTC_1502 4534-4282 27.7 µM 0.453707478806133 0.329763652453201 no 1137 0.325019691661091 1556 3278949
SGTC_613 3914-0030 117 µM 0.453108483830558 0.329982449587465 no 1138 0.325235313314279 1492 1145395
SGTC_2868 9035608 32.47 µM 0.451647669063711 0.330516290668708 no 1139 0.325761411601218 1511 6462614
SGTC_2691 st077356 60.2 µM 0.451483705256594 0.330576231263384 no 1140 0.325820483267891 1655 2839272
SGTC_561 1550-0330 72.9 µM 0.451454036077052 0.330587077952284 no 1141 0.32583117272755 1515 6812934
SGTC_1283 0922-0125 16.4 µM 0.450631742103864 0.330887755157135 no 1142 0.326127492612498 1650 3360884
SGTC_1266 0828-0227 32.9 µM 0.449144644858438 0.331431799080493 no 1143 0.326663658197908 1602 3913820
SGTC_2415 st077333 57.7 µM 0.449002632006907 0.331483772103223 no 1144 0.326714878985484 1795 2766255
SGTC_410 α-linolenic acid 100 µM 0.446203830393932 0.332508722033228 no 1145 0.327725008151386 1625 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2073 5212005 126 µM 0.445841022036805 0.332641678123564 no 1146 0.327856043642772 1532 691789
SGTC_629 3448-6466 76.7 µM 0.445761323647431 0.332670887510611 no 1147 0.327884831149553 1560 573744
SGTC_332 4112-0506 40.9 µM 0.445654452331534 0.332710057344794 no 1148 0.327923435275525 1584 2790355
SGTC_3193 9111931 49.47 µM 0.445114182203836 0.33290810185794 no 1149 0.328118620136203 1592 17087244
SGTC_180 1486-1293 102.781 µM 0.443999969064391 0.333316681381268 no 1150 0.328521303138965 1722 4140536
SGTC_1005 4092-0690 4.4 µM 0.441601998038555 0.334196682767482 no 1151 0.329388618953326 1530 1529343
SGTC_1028 k015-0029 4.8 µM 0.4410934559421 0.334383423667155 no 1152 0.329572670441901 1537 4588309
SGTC_938 3126-1755 342 µM 0.440603965368377 0.334563207406114 no 1153 0.329749865805094 1602 1777771
SGTC_3047 9092122 49.47 µM 0.440582213549653 0.334571197456648 no 1154 0.329757740840692 1523 17173831
SGTC_525 k781-2675 26.7 µM 0.439754491910975 0.334875298372975 no 1155 0.330057465504851 1585 3651118 YDL195W SEC31
SGTC_2931 9014674 55.67 µM 0.438742180909916 0.335247363749119 no 1156 0.330424179778074 1499 2996810
SGTC_1760 st045453 10.4495 µM 0.438085624503736 0.335488761336786 no 1157 0.330662107440203 1618 3323419 YIL048W NEO1
SGTC_2409 alverine citrate 63.97 µM 0.437749233399746 0.335612469342809 no 1158 0.330784037805888 1708 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_252 miconazole 1.30953 nM 0.437351840669694 0.335758633688824 no 1159 0.330928102326843 1575 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2824 7998404 51.95 µM 0.435987922215355 0.336260483113583 no 1160 0.331422746253579 1597 837851
SGTC_471 1-acyl-paf 4 µM 0.432899338764397 0.337397995390363 no 1161 0.332543950206584 1513 16759367
SGTC_2727 riluzole 51.77 µM 0.432750506773759 0.337452847238316 no 1162 0.332598016494584 1585 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_57 miconazole 162.5 nM 0.431964432990583 0.33774261104571 no 1163 0.332883631741537 1516 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2816 7982706 58.44 µM 0.431083404152829 0.338067491675974 no 1164 0.333203863619719 1543 2981853
SGTC_2147 5545932 89.7195 µM 0.43075599093815 0.338188256521175 no 1165 0.333322901122979 1589 797404
SGTC_469 w7 172 µM 0.430422890440278 0.338311136181324 no 1166 0.333444023579315 1615 45115570 A P450 inhibitor.
SGTC_484 loperamide 105 µM 0.426769189486274 0.339660102263356 no 1167 0.334773724897062 1587 3955 An opioid-receptor agonist.
SGTC_691 1548-0686 185 µM 0.424303825414183 0.340571491132183 no 1168 0.33567212486881 1544 46495133
SGTC_3353 9151644 39.2805 µM 0.423723896069769 0.340786013338665 no 1169 0.33588359290425 1588 4909158
SGTC_1458 k015-0034 6.33 µM 0.420918588530405 0.341824453296468 no 1170 0.336907265509634 1522 3598957
SGTC_3283 9109332 35.8195 µM 0.419241512319126 0.342445828868428 no 1171 0.337519818192584 1555 17027281
SGTC_2966 9084041 48.03 µM 0.41787803743533 0.342951326199543 no 1172 0.338018145468663 1448 17741380
SGTC_1008 4106-0037 6 µM 0.416892695388388 0.343316808951115 no 1173 0.338378448343962 1604 2905394
SGTC_2148 5546263 113.568 µM 0.416818320489861 0.343344402018075 no 1174 0.338405650485654 1613 792097
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.416542132228478 0.343446875094398 no 1175 0.338506671948561 1553 2333 A French combination drug.
SGTC_304 1310-0298 97 µM 0.413582373111133 0.344545744369048 no 1176 0.339589992288419 1580 1550234
SGTC_874 0599-0792 117 µM 0.413269314813706 0.344662050424947 no 1177 0.339704654489758 1747 765305
SGTC_2310 7668677 200 µM 0.412783156603993 0.344842694912233 no 1178 0.339882746482198 1650 2197143
SGTC_2110 5483698 200 µM 0.412778498546134 0.344844425903645 no 1179 0.339884453018998 1621 2848765 YHR062C RPP1
SGTC_1059 3448-6867 171 µM 0.412427857680298 0.344974737669998 no 1180 0.340012924031681 1674 3934407
SGTC_612 0302-0167 22.4 µM 0.410507964958829 0.345688570018484 no 1181 0.340716680948145 1704 235821
SGTC_2340 7987427 183.45 µM 0.408735747656874 0.346347982777752 no 1182 0.341366798424785 1641 2239331
SGTC_690 glyoxal 20.3 µM 0.408311769622809 0.346505807148175 no 1183 0.341522399773153 1576 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2038 4100038 30.985 µM 0.408073823438738 0.346594393476749 no 1184 0.341609738617474 1643 3596803
SGTC_1887 st057648 70.8 µM 0.406589875869618 0.347147049841744 no 1185 0.342154617134194 1734 688672
SGTC_2752 diclazuril 33.15 µM 0.405837419680302 0.347427406257924 no 1186 0.342431031055744 1669 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_313 3474-0040 5.03 µM 0.404529750295451 0.347914827197138 no 1187 0.342911602677806 1588 1043375 YIL048W NEO1
SGTC_2421 5690543 90.72 µM 0.403810727901729 0.348182942927409 no 1188 0.343175953517882 1649 3397993
SGTC_1148 3909-7663 27.7 µM 0.402761043035253 0.348574495394865 no 1189 0.343562011258968 1698 4084526
SGTC_666 0272-0154 136 µM 0.401562386519678 0.349021814478892 no 1190 0.344003058076683 1649 6870312
SGTC_227 fluconazole 33.516 µM 0.400489710940964 0.349422297510126 no 1191 0.344397930142267 1586 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2316 5844804 197.44 µM 0.39850396151426 0.350164118588756 no 1192 0.345129369367373 1765 776813
SGTC_1646 st011709 75.6 µM 0.397213066291681 0.350646668377827 no 1193 0.345605173811176 1712 5757843
SGTC_1009 4106-0057 9.87 µM 0.396063858312324 0.351076456907863 no 1194 0.346028959830323 1686 2928005
SGTC_972 1319-0219 195 µM 0.395960288375861 0.351115200058607 no 1195 0.346067162132661 1599 23903702
SGTC_98 0074-0023 107.663 µM 0.395857437509377 0.351153675753175 no 1196 0.346105100752764 1571 3563821
SGTC_676 falcarinol 140 µM 0.395338100666571 0.351347978849342 no 1197 0.346296692224784 1756 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1331 1472-0049 76.2 µM 0.395003042359437 0.351473357163033 no 1198 0.3464203213478 1597 24051409
SGTC_2075 5212009 200 µM 0.394105827652075 0.351809173104038 no 1199 0.346751454322981 1709 780898
SGTC_2245 6637752 200 µM 0.393367564520825 0.35208558225644 no 1200 0.347024011240016 1770 681890
SGTC_330 1488-0319 80.1 µM 0.393156819891061 0.352164500375196 no 1201 0.347101829881039 1659 6846614
SGTC_3305 9127027 53.8275 µM 0.386927026337799 0.354500251113343 no 1202 0.349405116204832 1657 41905295
SGTC_2203 7227154 166.4 µM 0.386380894720148 0.354705276120143 no 1203 0.349607298717655 1656 896304
SGTC_137 0438-0332 85.389 µM 0.386120100504805 0.354803196559814 no 1204 0.349703861982743 1639 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1354 1498-1681 81 µM 0.385243653721421 0.355132346416401 no 1205 0.350028451763495 1658 5754243
SGTC_188 3229-0966 278.469 µM 0.384792055307408 0.355301986564087 no 1206 0.350195742862996 1779 5722370
SGTC_2388 9080168 200 µM 0.38460790482524 0.35537116978534 no 1207 0.350263968314845 1577 15943073
SGTC_2449 5812982 45.77 µM 0.384213970056302 0.355519182555519 no 1208 0.350409932445546 1652 776185
SGTC_906 1165-0455 526 µM 0.383919727749081 0.355629752181883 no 1209 0.35051897207549 1604 3252859
SGTC_1457 k015-0032 57.3 µM 0.382857050387564 0.356029183494138 no 1210 0.350912879104146 1636 4302660
SGTC_2304 7443016 91.4 µM 0.382834101902019 0.35603781094637 no 1211 0.350921387284066 1622 939854
SGTC_353 1988-1175 58.3 µM 0.381026475316221 0.356717616982633 no 1212 0.351591801640084 1585 2788357
SGTC_1184 1269-1718 139 µM 0.380655694551756 0.356857115297449 no 1213 0.351729374332908 1765 5403821
SGTC_3020 9089140 49.47 µM 0.379320344423451 0.357359670663461 no 1214 0.352224996938153 1652 17217859
SGTC_2225 6654152 15.4 µM 0.379295406587336 0.357369058306639 no 1215 0.352234255145209 1718 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_231 b-estradiol 524 µM 0.378389255773925 0.357710229834751 no 1216 0.352570724284651 1620 450 A steroid.
SGTC_3151 9099821 49.47 µM 0.377601805492082 0.358006802220928 no 1217 0.352863211620239 1619 17174189
SGTC_1625 st003711 30.1 µM 0.37364285234005 0.359499133016433 no 1218 0.354335023883551 1731 24207034 YER133W GLC7
SGTC_2723 salbutamol 83.58 µM 0.373261445349499 0.359643018367595 no 1219 0.354476934192299 1737 9884233 β2-adrenoceptor agonist
SGTC_2735 sertaconazole 140 nM 0.3731422225622 0.3596879991109 no 1220 0.354521297626088 1744 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_881 0833-0569 170 µM 0.373105829241528 0.359701730083159 no 1221 0.354534840167645 1595 5418700
SGTC_615 k087-0205 167 µM 0.372344145114419 0.359989150275572 no 1222 0.354818317291017 1594 9642773
SGTC_2098 5376439 882.5 nM 0.372141410218821 0.360065665287624 no 1223 0.354893782996052 1787 2844116
SGTC_1423 4048-0112 5.59 µM 0.371423793441839 0.360336549020446 no 1224 0.355160953216908 1754 X1423
SGTC_134 0269-0018 6.916 µM 0.369131882314402 0.361202161479698 no 1225 0.356014712890296 1621 4378915
SGTC_1219 1469-0211 33.1 µM 0.368465592397558 0.361453940484658 no 1226 0.35626304824834 1787 6822282
SGTC_1085 doxorubicin 7.67 µM 0.367784490892929 0.361711378550512 no 1227 0.356516967110152 1776 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1019 4262-0212 3.4 µM 0.365380854726789 0.362620388018127 no 1228 0.357413565261092 1803 4677213
SGTC_1859 st055998 20 µM 0.36418235277141 0.363073928503995 no 1229 0.357860921973671 1818 676301
SGTC_2952 9073731 13.78 µM 0.36301913348575 0.363514300929034 no 1230 0.358295295730414 1619 16457353
SGTC_1075 aripiprazole 15.2 µM 0.36283679606016 0.363583346738836 no 1231 0.35836340150935 1667 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1977 st070720 65.3 µM 0.360399548845826 0.364506685097529 no 1232 0.359274181978997 1664 682188
SGTC_1983 st071813 46.9 µM 0.36023468057781 0.36456917304579 no 1233 0.359335820932553 1696 11838595
SGTC_1240 0356-0016 42.1 µM 0.360180441616327 0.36458973134472 no 1234 0.359356099939692 1716 4305613
SGTC_3122 9126309 49.47 µM 0.360025701768368 0.364648384830121 no 1235 0.3594139566627 1758 17591206
SGTC_3264 9137442 49.47 µM 0.359898280707062 0.36469668562378 no 1236 0.359461601400733 1775 17015726
SGTC_1203 3992-3522 103 µM 0.359876606064512 0.364704901923857 no 1237 0.359469706107798 1901 5322312
SGTC_1040 k898-0338 155 µM 0.358840215792475 0.365097843309768 no 1238 0.359857312842947 1857 20969351
SGTC_2873 9040596 71.43 µM 0.358638144692692 0.365174473919738 no 1239 0.359932903612524 1637 6463863
SGTC_2128 5255449 168.493 µM 0.358207316077252 0.365337873295103 no 1240 0.360094086295768 1659 736008
SGTC_664 1222-0054 14.9 µM 0.357523963094623 0.365597097134865 no 1241 0.360349795040257 1689 6813991
SGTC_896 0964-0007 44.5 µM 0.356655415532438 0.365926661476921 no 1242 0.360674893231644 1791 6756758
SGTC_1500 4488-1866 171 µM 0.356265347454307 0.366074702315931 no 1243 0.360820928877656 1784 2900003
SGTC_1341 1486-1360 280 µM 0.355729485178639 0.366278108299164 no 1244 0.361021580775633 1659 3976547
SGTC_1057 3448-5381 134 µM 0.353088436253147 0.367281162316799 no 1245 0.362011070909774 1789 5497911
SGTC_3017 9080681 49.47 µM 0.352720689857373 0.367420902163587 no 1246 0.362148923400437 1676 16451914
SGTC_2893 9048488 25.97 µM 0.350563354949958 0.368241020319104 no 1247 0.362957976168008 1620 6467338
SGTC_3273 9137859 49.47 µM 0.350126661379891 0.368407104088175 no 1248 0.363121821417865 1740 2377234
SGTC_2357 9067248 200 µM 0.350101746503278 0.368416580482678 no 1249 0.36313117011106 1727 9150235
SGTC_750 4073-0104 132 µM 0.35006849582826 0.368429227529879 no 1250 0.363143646734129 1657 22330957
SGTC_2862 9027634 71.43 µM 0.348523216576676 0.369017138636711 no 1251 0.363723640584236 1634 5012562
SGTC_2090 5301565 104.445 µM 0.347171064719101 0.36953182478436 no 1252 0.364231403762414 1717 2056344
SGTC_1862 st057513 3.81 µM 0.346595425578679 0.369751008404933 no 1253 0.364447641498791 1680 5393163
SGTC_2630 antimycin a 100 µM 0.346022524471727 0.369969191500973 no 1254 0.364662893537641 1642 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3248 9135562 49.47 µM 0.345940499476205 0.370000433247037 no 1255 0.364693715696892 1724 17650701
SGTC_1829 berberine 14.4 µM 0.345863200250017 0.370029875823464 no 1256 0.364722762875793 1830 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1093 fluphenazine 7.97 µM 0.345779954823458 0.370061584105721 no 1257 0.364754045361408 1742 6602611 An atypical antipsychotic.
SGTC_2871 9038510 12.99 µM 0.345543747133976 0.370151560704314 no 1258 0.364842813862118 1851 4945164
SGTC_1871 st057448 67.3 µM 0.344394419411715 0.370589465730387 no 1259 0.365274842572468 1799 691747
SGTC_799 1310-0557 151 µM 0.34410938149283 0.370698093923191 no 1260 0.365382013927077 1726 5354492
SGTC_350 k064-0020 19.8 µM 0.34334071720351 0.370991083894848 no 1261 0.36567107624842 1837 2790705
SGTC_2159 5658611 73.75 µM 0.342304964865857 0.371385997477977 no 1262 0.366060699797855 1817 793844
SGTC_2568 diosmetin 100 µM 0.340868832878259 0.371933792572599 no 1263 0.366601164454537 1812 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2833 9001315 45.46 µM 0.340685839031118 0.372003612003128 no 1264 0.366670050208956 1708 2989378
SGTC_151 3013-0144 2.285 µM 0.338755257605439 0.372740461621542 no 1265 0.367397054803445 1817 906558 YHR107C CDC12
SGTC_88 0180-0332 8.668 µM 0.337367161834336 0.373270547552368 no 1266 0.367920068076779 1736 3101745
SGTC_2522 biochanin a 4.94 µM 0.331548979979324 0.375494994467887 no 1267 0.370114925151533 1785 5280373 A possible chelator.
SGTC_1165 k072-0275 30.3 µM 0.331271278973376 0.375601271245612 no 1268 0.370219791864525 1779 6153523 YGL055W OLE1
SGTC_964 1287-0107 19.4 µM 0.328588448193027 0.376628481414017 no 1269 0.371233390334467 1831 51516812 YPR165W RHO1
SGTC_108 0509-0257 621.132 µM 0.327926921682286 0.376881903264979 no 1270 0.37148345885342 1828 536624
SGTC_713 1488-1073 324 µM 0.327662817635901 0.376983092774303 no 1271 0.37158330993247 1836 3312542
SGTC_567 1080-0542 68.4 µM 0.327633465166041 0.376994339477593 no 1272 0.371594407894706 1833 5950415
SGTC_229 benomyl 22.8748 µM 0.322695667289862 0.378887786375364 no 1273 0.373462866878875 1728 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2170 morpholine 200 µM 0.322018391486676 0.379147722380061 no 1274 0.373719380816961 1816 121171 Reacts with secondary amines.
SGTC_2706 st078239 82.5 µM 0.321487654527145 0.379351455508207 no 1275 0.3739204331993 1740 15434492
SGTC_1427 4048-4900 550 nM 0.320869548748074 0.379588768997054 no 1276 0.374154625648963 1859 24132586
SGTC_2233 sulbentine 40.3845 µM 0.320557764742728 0.379708491535898 no 1277 0.374272774289327 1759 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_165 k038-0023 64.381 µM 0.320350108037702 0.379788236431728 no 1278 0.374351471078958 1707 46368543
SGTC_929 2805-0021 398 µM 0.320242832350917 0.379829434737353 no 1279 0.374392127979837 1757 3098024
SGTC_1663 st014140 55.4 µM 0.318179691722165 0.380622031015085 no 1280 0.375174318286987 1801 4207120
SGTC_411 enrofloxacin 100 µM 0.317110469549141 0.38103299131057 no 1281 0.37557989050234 1920 71188 A bacterial gyrase inhibitor.
SGTC_2750 bromebric acid 70.15 µM 0.316494267120795 0.381269892451007 no 1282 0.375813687944636 1768 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1691 st019933 84.6 µM 0.31616823700561 0.381395253854718 no 1283 0.375937407640216 1885 6176082
SGTC_419 nsc-638432 893 µM 0.314806368210804 0.381919038625458 no 1284 0.376454338135776 1750 368090
SGTC_2033 5192550 145 µM 0.314449202890364 0.382056442868035 no 1285 0.376589945664746 1729 182073
SGTC_2823 7987624 58.44 µM 0.311747937688887 0.383096120288145 no 1286 0.377616046571526 1766 2239440
SGTC_3188 9110789 49.47 µM 0.307829234672367 0.384605867963933 no 1287 0.379106137494486 1860 849217
SGTC_86 0417-1630 471.922 µM 0.305966399046829 0.385324173148316 no 1288 0.379815114672104 1838 3634867
SGTC_2949 9072542 2.23 µM 0.305252265918482 0.385599645759641 no 1289 0.380087014118263 1717 16457352
SGTC_457 grayanotoxin iii 135 µM 0.302892105968329 0.386510473307989 no 1290 0.380986043736993 1821 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1559 coumarin 343 70.1 µM 0.301918500669939 0.386886387406254 no 1291 0.381357096002808 1844 108770 A hepatotoxic, DNA x-linker.
SGTC_3296 9122258 64.045 µM 0.301421409143915 0.387078357996018 no 1292 0.381546585432452 1790 4730474
SGTC_341 1486-1430 230 µM 0.299083841820495 0.387981467195085 no 1293 0.382438037350695 1728 2054753 YPL210C SRP72
SGTC_1378 2093-0007 380 nM 0.298223724346386 0.388313922748647 no 1294 0.382766207878578 1760 3618014
SGTC_1764 st044502 93.5 µM 0.296720568782067 0.388895123967504 no 1295 0.383339926132465 1788 8407
SGTC_2784 7567673 72.73 µM 0.295984730161355 0.389179729735942 no 1296 0.383620871387704 1765 3471247
SGTC_3187 9109394 49.47 µM 0.295518205748381 0.389360201660521 no 1297 0.383799023427924 1730 17098090
SGTC_3140 9094243 49.47 µM 0.294914950743627 0.389593602301442 no 1298 0.38402942529668 1973 19291112
SGTC_448 monastrol 171 µM 0.294023812275755 0.38993845851381 no 1299 0.384369853807808 1840 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3210 9128157 49.47 µM 0.293200933094054 0.390256976440835 no 1300 0.384684285455444 1682 17590849
SGTC_779 1360-0071 233 µM 0.29243296616973 0.390554305551576 no 1301 0.384977802944749 1934 7566
SGTC_1034 k072-0165 12.7 µM 0.291696007012699 0.390839689763689 no 1302 0.385259531232184 1925 5835461
SGTC_2877 9040724 71.43 µM 0.291368789181788 0.390966422298073 no 1303 0.385384641062222 1927 6463895
SGTC_1596 piperlongumine 63 µM 0.290830642838682 0.391174873310973 no 1304 0.38559042411455 1919 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2693 st077581 40.7 µM 0.289140365103332 0.391829805530765 no 1305 0.386236982624253 1870 25238761
SGTC_662 k832-1615 104 µM 0.288784839021287 0.391967600381514 no 1306 0.386373017376326 1846 5878478
SGTC_29 0299-0004 12.984 µM 0.287799123048685 0.39234971514239 no 1307 0.386750254343215 1864 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2605 digitonin 300 nM 0.287277590086634 0.392551930453401 no 1308 0.386949890158251 1958 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1518 st038567 90.8 µM 0.285549683445337 0.39322210312111 no 1309 0.387611523069768 1796 77966
SGTC_204 PMA1.184 62.41 µM 0.285237247437273 0.39334331601462 no 1310 0.387731192886365 1820 2252213 YGL008C PMA1
SGTC_2480 5767542 37.17 µM 0.28502258054514 0.393426604326027 no 1311 0.387813421177632 1848 2867358
SGTC_3181 9108277 49.47 µM 0.284444111277658 0.393651068088255 no 1312 0.388035029239743 1781 17097298
SGTC_1933 st074711 15.9 µM 0.283388421024535 0.394060799243602 no 1313 0.388439551716347 1873 17250958
SGTC_1026 k007-1105 30.6 µM 0.283348326124459 0.394076363063713 no 1314 0.388454917785783 1791 7066794
SGTC_139 0099-0334 718.624 µM 0.282405695015005 0.394442317163516 no 1315 0.388816224329291 1939 97690
SGTC_44 0929-0055 61.211 µM 0.281160926120255 0.394925711800136 no 1316 0.389293486352639 1769 1379590
SGTC_2736 butenafine 14.65 µM 0.280595395402872 0.395145383985981 no 1317 0.389510374071925 1888 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2182 6325192 200 µM 0.280574423865952 0.39515353071594 no 1318 0.389518417566639 1909 736248
SGTC_2173 5763948 167 µM 0.279200462559885 0.395687367727957 no 1319 0.390045494338311 1882 2867177
SGTC_1113 artemisinin 1.17947 µM 0.278790679777219 0.395846622102513 no 1320 0.390202733727647 1954 2240 An anti-malaria and mitochondrial poison.
SGTC_502 l-744,832 89.3 µM 0.278603014994209 0.395919560298844 no 1321 0.390274749330458 1930 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1170 0310-0127 64.8 µM 0.278231997294573 0.396063771554743 no 1322 0.39041713695331 1846 774975
SGTC_600 1495-0418 41.6 µM 0.275605326772582 0.397085140626633 no 1323 0.391425608950906 1825 5377768
SGTC_3002 9075603 71.4286 µM 0.275308403485509 0.397200642477164 no 1324 0.391539654398709 1887 20105405
SGTC_1747 st037496 66.6 µM 0.27524724131003 0.397224435414168 no 1325 0.391563147374586 1800 723305
SGTC_2811 7967822 32.47 µM 0.271343663161561 0.398743769149903 no 1326 0.393063363653531 1886 2232244
SGTC_1672 st016598 6.51 µM 0.269009737380108 0.399652904741344 no 1327 0.393961094722053 1800 4665860 YNL267W PIK1
SGTC_1820 st053765 18.6 µM 0.268913246589947 0.399690502610708 no 1328 0.393998221514947 1785 3690829
SGTC_2267 7931562 200 µM 0.26855938404527 0.399828393963351 no 1329 0.394134385564323 1702 934880
SGTC_957 1187-1561 14.1 µM 0.268503244757706 0.399850271183397 no 1330 0.394155988793745 1899 1538454
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.268470721084406 0.399862945651894 no 1331 0.39416850453397 1897 5377381
SGTC_1818 st052136 56.3 µM 0.267867007572965 0.400098231818661 no 1332 0.394400845029627 1799 674169
SGTC_1738 st035555 74 µM 0.267518178172783 0.400234198158778 no 1333 0.394535109938186 1858 5331140
SGTC_2260 7964312 200 µM 0.26734415857318 0.400302031849213 no 1334 0.394602095003245 1952 231951
SGTC_1803 st050068 52.4 µM 0.264830471837505 0.401282213745155 no 1335 0.395570030806343 1865 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_127 0180-0333 59.125 µM 0.264129448522904 0.401555680462873 no 1336 0.395840086380661 1940 771601
SGTC_383 2324-0395 7.37 µM 0.262897015415518 0.402036565090547 no 1337 0.396314978388709 1904 3146421
SGTC_1313 1220-0047 237 µM 0.261749950851532 0.402484272956664 no 1338 0.39675711372054 1888 3528706
SGTC_3146 9095609 49.47 µM 0.260868614956611 0.402828351882741 no 1339 0.397096914323865 1890 17173999
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.260038984594054 0.403152313435565 no 1340 0.397416851164863 1942 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1698 5-fluorocytosine 1.055 µM 0.259340998345819 0.403424920913793 no 1341 0.397686074533826 1972 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_83 0170-0301 39.027 µM 0.25852676099105 0.403742991053293 no 1342 0.398000199214129 1917 3089716
SGTC_975 1335-0046 28.5 µM 0.257958893234453 0.403964858141947 no 1343 0.398219316106842 1760 16486740
SGTC_187 1488-2104 32.728 µM 0.257091909815876 0.404303649905057 no 1344 0.398553911367041 1930 2852859
SGTC_2992 9074591 71.4286 µM 0.25603212214946 0.404717881403865 no 1345 0.398963016937572 1925 17741321
SGTC_3135 9127742 49.47 µM 0.255711836547085 0.404843090146269 no 1346 0.399086677366541 1815 3643468
SGTC_2942 9052777 62.25 µM 0.25457472868963 0.405287696532138 no 1347 0.399525789899607 1849 6469503
SGTC_808 0711-0032 135 µM 0.25333448573107 0.40577276786379 no 1348 0.4000048746479 1984 4252555
SGTC_2405 ticlatone 3.52 µM 0.252796549779993 0.405983204994912 no 1349 0.400212717002218 1628 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2991 9074669 71.4286 µM 0.252382632110979 0.406145145458743 no 1350 0.400372661648768 1924 17333109
SGTC_2122 5258151 111.688 µM 0.251630471040983 0.406439460796371 no 1351 0.400663351903497 1842 2173356
SGTC_141 0443-0274 32.331 µM 0.248794880428079 0.407549481469084 no 1352 0.401759725722106 2008 1627241
SGTC_2610 ononetin 44.17 µM 0.24759779836007 0.408018314846517 no 1353 0.402222807175532 1811 259632
SGTC_2996 9066192 71.4286 µM 0.244998298192435 0.409036853563457 no 1354 0.403228874529161 1784 6472854
SGTC_2710 st078562 53.7235 µM 0.244164815468999 0.409363560018427 no 1355 0.403551587839455 1892 17250908
SGTC_962 1254-0300 21.5 µM 0.244147349379626 0.409370407006357 no 1356 0.403558351177903 1864 7340576
SGTC_104 0074-0074 590.992 µM 0.242389868619058 0.410059508737304 no 1357 0.404239042011507 1972 3943124
SGTC_2145 5634607 200 µM 0.241217885645833 0.410519193500385 no 1358 0.404693124692179 1834 308662
SGTC_3294 9122953 26.2835 µM 0.239420419361951 0.411224449139254 no 1359 0.405389799000151 1873 16459826
SGTC_2141 5621638 7.665 µM 0.238530849646713 0.411573587897227 no 1360 0.405734695592078 1989 2856238
SGTC_1102 cgs 12066b 26.1 µM 0.238107884513604 0.411739618041668 no 1361 0.405898709814707 1897 6438352 A 5-HT1B full agonist.
SGTC_3112 9123419 49.47 µM 0.237763115365255 0.411874964935568 no 1362 0.406032414010919 1982 17015854
SGTC_3170 9103054 49.47 µM 0.237413383807186 0.412012270647338 no 1363 0.406168053867116 1874 16432970
SGTC_797 k781-0471 270 µM 0.235757482903564 0.412662528538422 no 1364 0.406810430969187 1939 23738129
SGTC_62 0180-0423 3.232 µM 0.234820052489062 0.413030755716623 no 1365 0.407174201609739 1943 30102 YGL099W LSG1
SGTC_1063 disulfiram 1.84 µM 0.234251168690668 0.413254253344213 no 1366 0.407394996499571 1901 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1473 k844-0725 134 µM 0.232394614602719 0.413983833786013 no 1367 0.408115765683419 1953 54682906
SGTC_851 0394-0702 453 µM 0.231669167576408 0.414268997593068 no 1368 0.408397490312057 2018 762646
SGTC_3325 9138760 55.175 µM 0.230965781029385 0.414545532873377 no 1369 0.408670693051404 1839 43844959
SGTC_262 fenpropimorph 62.5 µM 0.230634150393897 0.414675927622297 no 1370 0.408799517286446 1872 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1853 st056710 91.2 µM 0.230352450890499 0.414786697200094 no 1371 0.40890895316512 2050 269167
SGTC_751 0833-0568 350 µM 0.230256837204606 0.414824295852154 no 1372 0.408946099210655 1911 6954252
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.229685501464851 0.415048981337171 no 1373 0.409168080946378 1851 5282362
SGTC_1197 1601-0112 267 µM 0.229012955628332 0.415313504661423 no 1374 0.409429423282927 1836 7350313
SGTC_2821 7996764 71.43 µM 0.228976246516763 0.415327944063917 no 1375 0.409443689113378 1927 2987135
SGTC_2900 5328528 85.29 µM 0.224986113464917 0.41689812685306 no 1376 0.410995038596203 1902 795359
SGTC_1591 genipin 88.4 µM 0.224402075214142 0.417128067376248 no 1377 0.411222228037788 1994 442424 A DNA cross-linking agent.
SGTC_3237 9133362 49.47 µM 0.224331341569551 0.417155917703099 no 1378 0.411249745274411 1995 43845137
SGTC_970 1315-0089 19.5 µM 0.223881748841937 0.417332947905356 no 1379 0.411424658799633 1931 6811083 YLR033W RSC58
SGTC_488 nitrendipine 139 µM 0.221807169018158 0.418150044400254 no 1380 0.412231999198848 1977 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_384 k007-0144 5.16 µM 0.221095136570651 0.418430567991178 no 1381 0.412509178508183 1932 6824886
SGTC_1768 st044301 37.178 µM 0.220121095616626 0.418814383784427 no 1382 0.412888422891733 1886 3931349
SGTC_1892 st058411 7.36 µM 0.219507933726173 0.419056036717129 no 1383 0.413127200172513 2017 3934738
SGTC_2082 5219693 150 µM 0.218804432225105 0.419333330966059 no 1384 0.413401197058459 1918 2834649
SGTC_1856 st057054 55.7 µM 0.216671813948541 0.420174174433632 no 1385 0.414232057701416 2039 1266018
SGTC_3104 9120930 49.47 µM 0.215523257929071 0.420627175513715 no 1386 0.414679690450186 1940 17014836
SGTC_2936 9038235 15.59 µM 0.215297989927431 0.420716035640748 no 1387 0.414767498344417 1959 4749415
SGTC_765 1319-0117 244 µM 0.215169649785471 0.420766663018995 no 1388 0.41481752634028 1881 3487746 YGL099W LSG1
SGTC_369 0957-0393 4.5 µM 0.214320623941037 0.421101618112676 no 1389 0.415148518049741 1851 6997992
SGTC_2771 fluoxetine 41.05 µM 0.21377162399409 0.421318238323956 no 1390 0.415362577103285 2000 3386 A selective serotonin reuptake inhibitor.
SGTC_3070 9117005 49.47 µM 0.212891536621604 0.421665546154299 no 1391 0.415705781934291 2011 8779016
SGTC_1709 st033179 39.1045 µM 0.212798238096608 0.421702368017435 no 1392 0.415742169033405 1929 573381
SGTC_2978 9011784 42.97 µM 0.211884672213204 0.422062958585967 no 1393 0.41609850445472 2075 2994934
SGTC_1703 st026983 48.3 µM 0.211767542898503 0.422109195042698 no 1394 0.416144195617046 2053 1104023
SGTC_3025 9087895 49.47 µM 0.209316907741092 0.423076821407931 no 1395 0.417100426823145 2049 17173641
SGTC_642 0335-0876 158 µM 0.208800669292984 0.423280716090281 no 1396 0.417301924415988 1932 6812350
SGTC_3028 9087778 49.47 µM 0.208430313962983 0.423427005114508 no 1397 0.417446494463188 1899 17217395
SGTC_2028 5153890 36.43 µM 0.207143306816126 0.423935450265124 no 1398 0.417948970766969 1934 2830968 YPR165W RHO1
SGTC_1617 st002906 78 µM 0.207024804912352 0.423982272017236 no 1399 0.417995243301999 1905 5150859
SGTC_2408 sulbentine 18.36 µM 0.203907125909455 0.425214493940235 no 1400 0.41921303820051 1964 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1724 st037281 8.293 µM 0.202575696313406 0.425740947541597 no 1401 0.419733343830332 1897 574124 YDL195W SEC31
SGTC_1317 1273-0028 910 nM 0.201089118373821 0.426328903940976 no 1402 0.420314445243412 1948 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_711 k292-0785 179 µM 0.20102020229487 0.426356164919687 no 1403 0.420341388673758 1977 4146315
SGTC_2396 5342950 42.78 µM 0.200945056251108 0.426385890672611 no 1404 0.420370768196555 1925 1886677
SGTC_3130 9127414 49.47 µM 0.20085345294167 0.426422127042601 no 1405 0.420406582545137 2097 1494646
SGTC_1311 1190-0148 100 µM 0.200814430128766 0.426437563846996 no 1406 0.420421839580807 2022 1961333
SGTC_3302 9125395 16.351 µM 0.200537177821169 0.42654724369547 no 1407 0.420530242392189 1955 17599668
SGTC_939 1165-0479 45.3 µM 0.20046460746821 0.426575953160675 no 1408 0.420558617652213 2082 1377347
SGTC_1488 4013-0813 75.9 µM 0.20043209005165 0.426588817460783 no 1409 0.420571332208945 1931 2910057
SGTC_2570 licareol 100 µM 0.198104712261707 0.427509759477499 no 1410 0.421481569024909 1913 443158
SGTC_175 3793-3120 23.7 µM 0.197150887230836 0.427887301916549 no 1411 0.421854731272642 1931 5322297
SGTC_91 0417-1751 58.384 µM 0.196832016418109 0.428013531910463 no 1412 0.421979497860134 2087 6795624
SGTC_3289 9119912 71.43 µM 0.19627684591221 0.42823332240237 no 1413 0.422196741593105 1969 17014829
SGTC_1437 4092-1038 11.6 µM 0.195332498372503 0.428607238135095 no 1414 0.422566328513687 1962 3977136
SGTC_1344 1488-0097 29.1 µM 0.194131010040024 0.429083061732337 no 1415 0.423036650494265 1982 747966
SGTC_357 1325-0123 420 µM 0.194048365789311 0.429115795005876 no 1416 0.423069005583388 2070 1098503
SGTC_2043 5101342 149 µM 0.193895370282835 0.429176393898493 no 1417 0.42312890444347 1978 678451
SGTC_2017 5132927 60.65 µM 0.193336777969738 0.42939765688283 no 1418 0.423347612497665 1939 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3171 9103192 49.47 µM 0.192731270639364 0.429637528342944 no 1419 0.423584716068651 2100 13018434
SGTC_752 1896-0090 130 µM 0.191582811954437 0.43009256103559 no 1420 0.424034503590695 1966 772567
SGTC_2779 methotrexate 400 µM 0.188740321120546 0.431219187087481 no 1421 0.425148173908952 2078 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1801 st050089 28.441 µM 0.188391946795227 0.431357304537323 no 1422 0.425284706099857 2002 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3331 9141060 1.957 µM 0.18827194404988 0.431404883102567 no 1423 0.425331738730312 1927 4906567 YPR165W RHO1
SGTC_2967 9089538 49.85 µM 0.187417672041733 0.431743612712689 no 1424 0.425666583903462 2104 728216
SGTC_1795 st049545 62.3 µM 0.186366981050021 0.432160293729499 no 1425 0.426078492044397 2130 5291882
SGTC_1679 SEC14.276 6.7 µM 0.185387921246498 0.432548635328063 no 1426 0.4264623908312 2095 1005053 YMR079W SEC14
SGTC_3222 9128301 49.47 µM 0.183835217122448 0.433164644975195 no 1427 0.427071363836261 1976 4911358
SGTC_1373 2887-0003 58.5 µM 0.180499180857577 0.434488709621477 no 1428 0.428380348707646 1982 776948
SGTC_2662 daunorubicin 22.37 µM 0.1801295304277 0.434635468488487 no 1429 0.428525439921077 2059 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1839 st053978 48 µM 0.179775949035349 0.434775856043991 no 1430 0.428664232929252 2094 3788398
SGTC_2882 9058044 58.44 µM 0.179025651073656 0.435073784960255 no 1431 0.428958780208356 1902 18076804
SGTC_152 4469-0003 551.229 µM 0.17862975321489 0.435231003267899 no 1432 0.42911421526971 2128 697280
SGTC_391 gliotoxin 8.33 µM 0.178364512457681 0.435336340971546 no 1433 0.429218358668302 2019 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_866 0495-0101 262 µM 0.17603416667375 0.4362620108448 no 1434 0.430133550216196 1890 635694
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.175858120336028 0.436331954970611 no 1435 0.430202703820915 1994 65057 A dermal irritant. YDR527W RBA50
SGTC_2719 novobiocin 32.65 µM 0.175724344341132 0.436385106200675 no 1436 0.430255254441603 2078 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1830 st055982 50.3 µM 0.175165224312754 0.436607265483458 no 1437 0.430474904401517 2127 455313 An antimicrobial agent.
SGTC_1159 4092-0538 61.2 µM 0.175148986775058 0.436613717563145 no 1438 0.430481283630012 1989 717301
SGTC_1792 st045773 43.6 µM 0.1750003617416 0.436672775364729 no 1439 0.430539674671288 1968 2919270
SGTC_1838 st055369 84.5 µM 0.174930340535407 0.436700599555031 no 1440 0.430567184770225 2106 676036
SGTC_1312 1218-2183 165 µM 0.17480526553924 0.436750301141826 no 1441 0.430616325372268 2107 6744073
SGTC_708 3448-5400 146 µM 0.174653092308333 0.436810772216473 no 1442 0.430676114023954 2102 3462195
SGTC_2297 7971671 152.32 µM 0.174507105604719 0.436868786257302 no 1443 0.430733473491116 2063 909016
SGTC_1608 st001473 40.5 µM 0.174476409091508 0.436880984998372 no 1444 0.430745534608656 1925 7292267
SGTC_1534 6-azauridine 81.6 µM 0.174464178622312 0.436885845382322 no 1445 0.430750340160282 2032 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2226 7298446 200 µM 0.172740248484181 0.437571029558932 no 1446 0.431427802801892 2102 3283010
SGTC_2592 piperlongumine 83.33 µM 0.172179108044087 0.437794097972307 no 1447 0.431648360977886 1961 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2725 haloperidol 53.21 µM 0.172022114627863 0.437856510619066 no 1448 0.431710071597016 2091 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_400 oxethazaine 37.5 µM 0.171993494217792 0.437867888814093 no 1449 0.431721321823119 1992 4621 A local anesthetic.
SGTC_2718 lomofungin 53.02 µM 0.171510873191937 0.438059765078896 no 1450 0.431911040774004 2082 5351222 A RNA synthesis inhibitor.
SGTC_879 0831-1030 162 µM 0.169377161671969 0.438908241439041 no 1451 0.432749993149148 1948 1549252
SGTC_2675 theaflavin digallate 100 µM 0.168121370914543 0.43940774166982 no 1452 0.433243898540945 2061 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2434 5670830 169.91 µM 0.166942802820757 0.439876613791049 no 1453 0.433707526960388 1996 1549830
SGTC_1658 st012944 20 µM 0.166562048751851 0.440028108006264 no 1454 0.433857328590574 2083 24207260
SGTC_2807 7945238 51.95 µM 0.165492085646114 0.440453871263169 no 1455 0.434278339342819 2014 17148797
SGTC_3058 9093861 49.47 µM 0.165018789146816 0.440642228965391 no 1456 0.43446459659948 2066 17217477
SGTC_1392 3455-1037 33.9 µM 0.164725409903397 0.440758991783128 no 1457 0.434580057988158 2081 981132
SGTC_2881 9058953 51.95 µM 0.16351383725724 0.441241243382157 no 1458 0.435056939608226 2101 17122249
SGTC_1 0258-0098 57.368 µM 0.16338996625499 0.44129055363371 no 1459 0.435105701247523 2009 6790032 YDR047W HEM12
SGTC_587 k089-0003 57 µM 0.162529399528965 0.441633150916262 no 1460 0.435444489288371 2137 9659696
SGTC_3211 9128781 49.47 µM 0.162080049705484 0.441812057412584 no 1461 0.435621408243672 1870 17194361
SGTC_677 0929-0063 136 µM 0.161863379199265 0.441898327989077 no 1462 0.435706720816738 2129 1539583
SGTC_1947 st076332 61.6 µM 0.160622849153871 0.44239231637083 no 1463 0.436195228772099 2123 24208416
SGTC_1633 st005664 67.9 µM 0.160330175076173 0.442508874476381 no 1464 0.43631049502961 2036 2063822
SGTC_2712 st079126 47.7 µM 0.160191285557421 0.442564189279459 no 1465 0.436365196932858 2036 3152970
SGTC_3200 9114385 49.47 µM 0.160041536143363 0.442623830450706 no 1466 0.436424177390201 1974 17018030 YLR208W SEC13
SGTC_1545 lovastatin 49.4 µM 0.159285972446177 0.442924770990316 no 1467 0.43672178601266 2029 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3129 9127257 49.47 µM 0.159202365949832 0.442958073431282 no 1468 0.436754719939532 1885 837894
SGTC_1107 amlodipine 47 µM 0.158265515536284 0.443331270568476 no 1469 0.437123790122848 2073 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_584 0986-0246 15.4 µM 0.158250612496832 0.443337207645475 no 1470 0.437129661585879 2143 53315 YDR232W HEM1
SGTC_827 3253-0474 693 µM 0.158159706299106 0.443373423157195 no 1471 0.437165476887114 2132 5402065
SGTC_824 1304-0008 100 µM 0.156963399284706 0.443850055859538 no 1472 0.437636846812402 2022 768245
SGTC_3228 9131799 49.47 µM 0.156025016329644 0.444223983330644 no 1473 0.438006651259961 2050 17015818
SGTC_439 amiodarone 34.4 µM 0.154342968063167 0.444894371110648 no 1474 0.438669659787422 2070 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1335 1486-0900 202 µM 0.153351708101161 0.445289516103845 no 1475 0.43906046284653 2140 X1335
SGTC_2663 amphotericin b 100 µM 0.153030880739206 0.445417418866134 no 1476 0.439186961396004 2044 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2459 5811157 9.22 µM 0.153023826417435 0.445420231243891 no 1477 0.439189742904006 2154 2870684 YBR192W RIM2
SGTC_1757 st041620 31.8375 µM 0.151202987835092 0.446146244491711 no 1478 0.439907796721537 1995 5289815
SGTC_48 0382-0018 55 µM 0.150188072645353 0.44655099474504 no 1479 0.440308117905378 2149 762596
SGTC_855 0428-0020 25 µM 0.149519675659601 0.446817583270982 no 1480 0.440571792472873 2014 6812414
SGTC_2344 7990960 76.95 µM 0.149115808274228 0.446978676460266 no 1481 0.440731126075853 2022 140813
SGTC_1232 0279-0259 161 µM 0.148333188667046 0.447290869871491 no 1482 0.441039912148925 1991 1560000
SGTC_1940 st075990 51.1 µM 0.147317395448994 0.447696126837894 no 1483 0.441440751348428 2079 1084979
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.147131662235141 0.447770232165864 no 1484 0.441514049489234 2058 521171
SGTC_2197 6588183 93.1375 µM 0.14667671402259 0.447951758750751 no 1485 0.441693599652866 2079 884136
SGTC_27 0485-0001 32.618 µM 0.143149159574176 0.449359637467613 no 1486 0.443086190484134 2142 2054479
SGTC_1465 k213-0056 144 µM 0.143135122370812 0.449365241127475 no 1487 0.443091733439503 2017 24048857 YMR208W ERG12
SGTC_2355 9061122 103.12 µM 0.142518916484103 0.44961124081715 no 1488 0.443335069344018 2136 5302957
SGTC_1786 berberine 21.6 µM 0.141629853879559 0.449966203574 no 1489 0.443686192320836 2168 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2026 5148700 152 µM 0.141312266704366 0.450093011584795 no 1490 0.443811629714697 2062 79838
SGTC_1064 honokiol 6.76 µM 0.140711993192412 0.450332706109005 no 1491 0.444048735085835 2056 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2964 9083345 53.42 µM 0.139421229676403 0.450848180654485 no 1492 0.444558648668733 2044 17741579
SGTC_3247 9135149 49.47 µM 0.1381087297393 0.451372420790398 no 1493 0.445077243280529 2161 8934436 YOR116C RPO31
SGTC_1836 st055642 81 µM 0.137663454162222 0.451550292555287 no 1494 0.445253201844677 1986 8571
SGTC_858 0438-0351 2.77 µM 0.137214754904176 0.45172954179886 no 1495 0.445430524248155 2043 2799119
SGTC_1308 1187-1617 41.4 µM 0.137013819680221 0.451809815877202 no 1496 0.445509935803303 2081 2882570
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.136543875534459 0.451997567318071 no 1497 0.445695670831793 2142 16486 A toxic proline analog.
SGTC_2726 cimetidine 79.27 µM 0.136295748154808 0.452096703162046 no 1498 0.445793742500397 2181 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2414 st077232 92.9 µM 0.135837308201748 0.45227987432272 no 1499 0.445974948359374 1910 729801
SGTC_1875 nocodazole 6 µM 0.135584418088939 0.452380921731757 no 1500 0.446074912127605 2189 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2492 derrusnin 100 µM 0.133841550286655 0.453077403686124 no 1501 0.446763935192383 2068 1715307 Part of coumarin class of compounds.
SGTC_43 0570-0105 72.5 µM 0.13304338390997 0.453396413943396 no 1502 0.447079535026233 2104 1114046 YDL195W SEC31
SGTC_1597 7-benzyloxygramine 47.5 µM 0.132455844469554 0.453631260288542 no 1503 0.447311873117088 2007 260807
SGTC_1797 st048695 56.8 µM 0.131827702190969 0.453882353993225 no 1504 0.447560287295051 2178 592262 YIL048W NEO1
SGTC_1347 1493-0251 600 nM 0.131372797673 0.454064209120313 no 1505 0.447740203226043 2164 3986378
SGTC_927 2425-1185 123 µM 0.130245069237364 0.454515077480709 no 1506 0.448186269073294 2058 730375
SGTC_1522 st012842 45.6 µM 0.130046496414714 0.45459447342623 no 1507 0.448264820097253 2006 3491067 YOR116C RPO31
SGTC_736 0958-0254 92.6 µM 0.128904261136328 0.455051211791791 no 1508 0.448716702451884 2126 6812352
SGTC_2462 5162487 171.77 µM 0.128885046658553 0.455058895472889 no 1509 0.448724304506817 2187 2259986
SGTC_1530 rhein 70.4 µM 0.12810704847054 0.45537002340449 no 1510 0.449032129069809 2175 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_695 3505-6186 243 µM 0.127335695314951 0.455678520958697 no 1511 0.449337354733943 2133 1819379
SGTC_1733 st037357 54.9 µM 0.126855225602015 0.45587069513834 no 1512 0.449527492524604 2144 1272339 YGL099W LSG1
SGTC_696 1560-0013 611 µM 0.126267678047366 0.456105711428274 no 1513 0.449760020313246 2148 1650269
SGTC_816 0325-0417 81.3 µM 0.125481600239066 0.456420162900837 no 1514 0.450071145390609 2066 68101
SGTC_3197 9113331 49.47 µM 0.124527705656763 0.45680178206589 no 1515 0.450448732581949 2144 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1480 1070-0044 41.2 µM 0.124402860825008 0.456851730981767 no 1516 0.45049815416749 2183 3124987
SGTC_386 1509-0011 3.07 µM 0.124218615319647 0.456925446638019 no 1517 0.450571091748603 2127 3107280
SGTC_2514 salinomycin 42.74 µM 0.123580121352407 0.457180916163927 no 1518 0.450823866340486 2201 23682228 A polyether potassium ionophore.
SGTC_1780 st038448 24.544 µM 0.123479433524579 0.457221204257542 no 1519 0.450863729659585 2136 728868 YDL195W SEC31
SGTC_1737 st035557 69.7 µM 0.123456107977129 0.457230537542175 no 1520 0.450872964548072 2204 5716916
SGTC_1388 3346-4487 254 µM 0.120849874171491 0.458273520979736 no 1521 0.451904972842504 2125 3345614
SGTC_2373 9071805 200 µM 0.120549581884437 0.458393712941285 no 1522 0.45202390265896 2235 10149009
SGTC_2688 kanamycin b 96.69 µM 0.118236347618484 0.459319711459919 no 1523 0.45294019535097 2110 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_793 0488-0545 106 µM 0.118008716433198 0.459410845301678 no 1524 0.453030375714956 2017 292548
SGTC_281 1672-3440 14.9 µM 0.117982864650017 0.459421195390728 no 1525 0.453040617537063 2157 6833000
SGTC_1295 1013-0063 9.78 µM 0.117884129379064 0.459460725560903 no 1526 0.453079734239547 2208 6826038
SGTC_2300 7976697 71.57 µM 0.11763372764883 0.459560979505248 no 1527 0.45317893983621 2078 2236109
SGTC_402 epigallocatechin gallate 10 µM 0.116491117653852 0.460018481566119 no 1528 0.453631662628929 2068 65064 An antioxidant.
SGTC_3194 9111903 49.47 µM 0.116339312258629 0.460079268578899 no 1529 0.453691815226158 2152 17087251
SGTC_54 0159-0055 9 µM 0.115106141463442 0.460573098187295 no 1530 0.454180496039607 2215 3319099
SGTC_2476 5806916 10.51 µM 0.114513136258088 0.460810591882635 no 1531 0.45441551683534 2142 2870194
SGTC_1878 temozolomide 1 mM 0.113977026634651 0.461025311400505 no 1532 0.454628002419572 2222 5394 DNA alkylating agent.
SGTC_2349 9023730 187.07 µM 0.11385238731379 0.461075232848885 no 1533 0.454677404736241 2173 4126287
SGTC_1989 st071868 50.2 µM 0.113397637147137 0.461257377892941 no 1534 0.454857656456608 2232 16414057
SGTC_1025 k007-0731 70 µM 0.111626748134669 0.461966764592175 no 1535 0.455559681310244 2043 6256118
SGTC_2155 5570423 76 µM 0.111370564286821 0.46206939736562 no 1536 0.455661250560189 2079 797402
SGTC_1897 st060201 15 µM 0.1098304302117 0.46268646127981 no 1537 0.456271928604288 2037 611878
SGTC_2499 avocadenofuran 51.48 µM 0.109156247299763 0.46295660503701 no 1538 0.456539281237128 2199 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_557 1315-0110 16.2 µM 0.108985675911736 0.46302495536725 no 1539 0.45660692581052 2204 6833801
SGTC_3278 9139605 49.47 µM 0.108130138532929 0.46336779753578 no 1540 0.456946230608251 2168 7958859
SGTC_2124 5246320 200 µM 0.107869798464748 0.463472129836493 no 1541 0.45704948731626 2136 579342
SGTC_2240 6690706 185.951 µM 0.107442597203998 0.463643337853385 no 1542 0.457218931194412 2061 805876
SGTC_3013 9080133 71.4286 µM 0.10711904325517 0.463773011967455 no 1543 0.457347269878817 2163 17050193
SGTC_2714 st079313 56.9 µM 0.106927882164894 0.463849627414784 no 1544 0.457423096613568 2156 2939799
SGTC_7 0192-1582 4.227 µM 0.106165528583785 0.4641551843888 no 1545 0.45772551027135 2168 252616
SGTC_121 0557-0495 61.343 µM 0.106119940168538 0.46417345723577 no 1546 0.457743595254964 2209 3104427
SGTC_2447 5741742 33.78 µM 0.106096201931687 0.464182972077009 no 1547 0.457753012279035 2173 1776504
SGTC_2884 9058502 51.95 µM 0.106062226721472 0.464196590172542 no 1548 0.457766490379955 2134 6471554
SGTC_2186 6124449 200 µM 0.104778330719448 0.464711237702371 no 1549 0.458275852484251 2178 3834182 YLR033W RSC58
SGTC_2887 9044784 58.44 µM 0.104430899497419 0.464850515103165 no 1550 0.458413701241511 2243 6465546
SGTC_1635 st007035 42.4 µM 0.104194363307353 0.464945339632729 no 1551 0.458507553527601 2214 3716403
SGTC_3072 9116419 49.47 µM 0.104056152201844 0.465000747733684 no 1552 0.458562393683512 2124 17170162
SGTC_2187 6125751 200 µM 0.103980600061646 0.465031036473901 no 1553 0.458592372007051 2169 874498
SGTC_1504 k297-0033 30 µM 0.103248187941041 0.465324669875677 no 1554 0.458882997896029 2121 4388117
SGTC_2379 9035213 200 µM 0.100240567996553 0.46653065947864 no 1555 0.460076669793451 2255 646551
SGTC_2330 7979373 200 µM 0.10022504555008 0.466536884445837 no 1556 0.460082831324508 2100 1863007
SGTC_3356 9151811 4.48 µM 0.099844385037357 0.466689543301281 no 1557 0.460233934959201 2158 1859254 YPR165W RHO1
SGTC_245 methotrexate 289.6 µM 0.0994095071061324 0.466863951330004 no 1558 0.46040656728848 2171 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2149 5554786 194.827 µM 0.0989404839965553 0.467052060431443 no 1559 0.460592762502157 2127 745063 YPR165W RHO1
SGTC_3306 9127676 59.7925 µM 0.097681104969746 0.467557190507824 no 1560 0.461092759921848 2102 41905287
SGTC_338 4055-0136 114 µM 0.0975139400405094 0.467624243396992 no 1561 0.461159132218659 2217 2900563
SGTC_3168 9103419 49.47 µM 0.097239695711329 0.467734249767183 no 1562 0.461268022389005 2236 16649256
SGTC_1294 1000-1494 117 µM 0.0969677063746797 0.467843354036411 no 1563 0.461376020070731 2121 712797 YDL207W GLE1
SGTC_3095 9117207 49.47 µM 0.0962408666923807 0.468134926239764 no 1564 0.46166463725398 2225 17015229
SGTC_2378 9074213 121.43 µM 0.0952030479869895 0.468551277469042 no 1565 0.462076774521158 2235 657714
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0948489748933287 0.468693332105526 no 1566 0.462217392924358 2236 1377
SGTC_724 3910-0327 137 µM 0.0923187376409025 0.469708581885694 no 1567 0.463222400729012 2152 2885483
SGTC_2478 5763493 32.33 µM 0.0917128959570966 0.469951703440774 no 1568 0.463463075542438 2186 1365576 YLR208W SEC13
SGTC_506 n9-isopropylolomoucine 153 µM 0.0909201213092606 0.470269857263769 no 1569 0.463778030958643 2264 6610355
SGTC_693 4161-2696 114 µM 0.0905877732134889 0.470403239811857 no 1570 0.463910073773324 2201 805759
SGTC_1244 0416-0015 52.5 µM 0.0902129409335097 0.470553676685882 no 1571 0.464059000440955 2167 96201
SGTC_2621 lithochol-11-enic acid 100 µM 0.0895504294113146 0.470819582306538 no 1572 0.464322238828906 2246 6708711
SGTC_2432 5630864 12.22 µM 0.0880139151492029 0.471436327540053 no 1573 0.464932808187066 2170 5714970
SGTC_2516 gossypol 71.55 µM 0.0878635256012244 0.471496696474733 no 1574 0.464992573400161 2239 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1462 k081-0014 26.5 µM 0.0873735521179747 0.471693384739994 no 1575 0.465187295658396 2226 3270634
SGTC_2783 7738165 71.43 µM 0.0869292016833451 0.47187176468245 no 1576 0.465363893893733 2141 17201110
SGTC_2960 9079389 5.97 µM 0.0850543227853393 0.472624477371232 no 1577 0.466109101896991 2264 16457355
SGTC_47 0149-0135 24.25 µM 0.084472269217183 0.472858176001192 no 1578 0.466340474990172 2256 5239155
SGTC_1507 4075-3230 155 µM 0.08290425800624 0.473487789869787 no 1579 0.466963834149909 2266 659771
SGTC_337 1315-0038 354 µM 0.0810254537950636 0.474242285593396 no 1580 0.467710854926015 2163 1626437
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0807383326924345 0.474357596736935 no 1581 0.467825025616118 2244 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2756 carbadox 75.1 µM 0.0805374367007567 0.474438280160268 no 1582 0.467904911371052 2194 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3059 1327-0034 3 µM 0.0798068900841939 0.474731689561282 no 1583 0.468195422155853 2190 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3154 9100113 49.47 µM 0.0760053948045227 0.476258701542336 no 1584 0.469707403091197 2201 25237525
SGTC_2326 6164455 177.58 µM 0.07600213833626 0.476260009776633 no 1585 0.469708698487189 2212 2888790
SGTC_2589 lobaric acid 100 µM 0.0756844185487804 0.476387649872983 no 1586 0.469835086315749 2192 73157 A novel microtubule depolymerizer.
SGTC_1054 3429-0080 167 µM 0.0734703486665275 0.477277192317925 no 1587 0.470715919312691 2254 1162877
SGTC_2244 6635614 200 µM 0.0732897583796082 0.47734975277195 no 1588 0.470787770706166 2123 836499
SGTC_191 3914-0123 66.505 µM 0.0732808707820411 0.477353323792465 no 1589 0.470791306836033 2184 3144412
SGTC_1645 Cervolide 78 µM 0.0719250550123648 0.477898109228189 no 1590 0.471330775333928 2210 23173 A fragrance.
SGTC_2927 9011802 47.9 µM 0.0709568529421087 0.478287171483023 no 1591 0.471716047626886 2178 43912568
SGTC_2427 5545055 42.75 µM 0.0705087426880302 0.47846724710467 no 1592 0.47189437110595 2225 5372858
SGTC_1671 st016596 74.5 µM 0.0686364579343116 0.479219682377951 no 1593 0.472639499023898 2271 2829167
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0673891744219505 0.479720982928934 no 1594 0.473135943579159 2176 688803
SGTC_638 3970-0837 4.09 µM 0.067174407433133 0.479807304021099 no 1595 0.473221429501608 2226 4118451 YLR208W SEC13
SGTC_156 3474-0145 5.642 µM 0.0667198573844563 0.479990004009408 no 1596 0.473402362814191 2297 2265471
SGTC_365 0121-0052 13.6 µM 0.0665057164635356 0.480076076394785 no 1597 0.473487603354039 2264 3101739
SGTC_5 0352-0601 109.883 µM 0.0653437106548896 0.480543152271085 no 1598 0.473950170308596 2211 762456
SGTC_1014 4130-3005 69.3 µM 0.0653287699256612 0.480549157970773 no 1599 0.473956118088613 2269 743608
SGTC_643 k048-0106 28.4 µM 0.0648882268817235 0.480726244292452 no 1600 0.474131497213259 2256 6763920
SGTC_2702 st077768 96.8 µM 0.0644205308063101 0.480914249556032 no 1601 0.474317691380072 2232 6484119
SGTC_2258 7960471 200 µM 0.0641614629664523 0.481018391916497 no 1602 0.474420831118778 2147 2974708
SGTC_1470 k295-0292 231 µM 0.0641354081658857 0.481028865725359 no 1603 0.474431204115805 2282 5045612
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0638169203574191 0.481156896179589 no 1604 0.474558002612232 2232 6708760
SGTC_1340 1486-1359 257 µM 0.0633970098804782 0.481325700991224 no 1605 0.474725184116628 2206 4309068
SGTC_3233 9132340 49.47 µM 0.063324154990365 0.481354989137555 no 1606 0.474754190729702 2272 17682950
SGTC_375 3970-0961 9.27 µM 0.0627498962837511 0.481585848435294 no 1607 0.474982832080693 2236 2898222
SGTC_2189 6047310 154.431 µM 0.0627272930397713 0.481594935353437 no 1608 0.474991831741028 2264 711535
SGTC_3006 9075424 71.4286 µM 0.0626344215811832 0.481632271481389 no 1609 0.475028809380555 2236 7465181
SGTC_320 4092-0846 5.34 µM 0.0622866606767122 0.481772079539599 no 1610 0.475167275544163 2284 1359356
SGTC_3316 9136639 10.545 µM 0.0621860253998145 0.481812537705474 no 1611 0.475207345533013 2224 4903665
SGTC_2841 9004761 38.96 µM 0.0610374843896857 0.482274296137272 no 1612 0.475664678233991 2222 2991039
SGTC_1852 st056254 31.4 µM 0.0602973606175168 0.482571867494938 no 1613 0.475959402022586 2222 442583
SGTC_2431 5490079 200 µM 0.0599992803318808 0.48269171527629 no 1614 0.476078103935614 2259 5722345
SGTC_95 0471-0001 561.058 µM 0.0597109274598398 0.482807653489225 no 1615 0.47619293420582 2183 4015405
SGTC_1434 4073-0095 163 µM 0.0595786012992807 0.482860858435556 no 1616 0.476245630888449 2294 24133745
SGTC_424 splitomicin 100 mM 0.0585413636981214 0.483277915500021 no 1617 0.476658707752409 2115 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2390 9097792 176.6 µM 0.0580660513734805 0.483469037314639 no 1618 0.47684800791361 2173 4497149
SGTC_1463 k081-0032 34.1 µM 0.0579731580677276 0.48350638990955 no 1619 0.476885004657794 2272 977755
SGTC_2428 5615643 7.78 µM 0.0568093612943402 0.483974367216475 no 1620 0.477348528374276 2270 2253075
SGTC_1796 st049173 110.4 µM 0.0563807052806616 0.484146740783454 no 1621 0.477519263729025 2309 94134
SGTC_2064 5220758 200 µM 0.0555527781797557 0.484479679844887 no 1622 0.477849041962361 2246 788518
SGTC_2929 9013348 24.6 µM 0.0551495285009089 0.48464184487819 no 1623 0.478009669058514 2262 2995952
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0549402636597851 0.484726000789803 no 1624 0.478093027270366 2327 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1076 itraconazole 331 nM 0.0535122561052237 0.485300292376057 no 1625 0.478661882840946 2314 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_168 3970-0862 530.542 µM 0.0522793607997759 0.48579614163439 no 1626 0.479153049260059 2252 3135186
SGTC_757 1066-0008 322 µM 0.0516153130510675 0.486063219351227 no 1627 0.479417608777102 2289 6842497
SGTC_1236 0330-0013 258 µM 0.0511219759936654 0.486261641870154 no 1628 0.479614162288075 2265 4617066
SGTC_1187 1391-0724 117 µM 0.0496990351399057 0.486833974353299 no 1629 0.480181112678957 2216 6997986
SGTC_800 3448-7362 155 µM 0.0494592671955886 0.486930416048137 no 1630 0.480276648758768 2319 15991913
SGTC_301 4119-0100 24.5 µM 0.0483572370493476 0.487373694616734 no 1631 0.480715769649649 2300 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2517 totarol 10 µM 0.0477450836829649 0.487619932829432 no 1632 0.480959701734065 2244 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2749 bexarotene 57.39 µM 0.0476446725668291 0.487660323575398 no 1633 0.480999714437329 2263 82146 An retinoic acid receptor inhibitor.
SGTC_635 k038-0028 24.7 µM 0.0469708993931931 0.487931354601153 no 1634 0.481268210419875 2274 4035102
SGTC_225 nsc-122657 1.016 µM 0.0466103902557598 0.48807637478417 no 1635 0.481411875402878 2302 275685
SGTC_3236 9132701 49.47 µM 0.0465972324229824 0.488081667748791 no 1636 0.48141711892136 2256 24282524
SGTC_2020 4017018 200 µM 0.0463061616796668 0.488198756498463 no 1637 0.48153311413459 2285 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1358 1509-0022 2.48 µM 0.0456176355703624 0.48847573326889 no 1638 0.481807506325999 2288 3258434
SGTC_373 0844-0104 25.9 µM 0.0441803466158629 0.489053936291941 no 1639 0.48238032394169 2336 5375804
SGTC_1643 st009866 20.2 µM 0.0432634881719726 0.489422788850436 no 1640 0.482745748086837 2327 3156273 YOR207C RET1
SGTC_2057 5236571 38.335 µM 0.0431196091506747 0.489480672273727 no 1641 0.482803093997011 2310 54684039 YBR257W POP4
SGTC_3328 9140624 29.0385 µM 0.0401758943821444 0.490664993898143 no 1642 0.483976447803182 2323 4904392
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0382606824397136 0.491435570911159 no 1643 0.484739919342611 2333 6312947
SGTC_3229 9132204 49.47 µM 0.0380855504643454 0.491506036121616 no 1644 0.48480973600565 2313 17682924
SGTC_684 1140-0066 328 µM 0.037871108783097 0.491592318146083 no 1645 0.484895224184493 2281 6813534
SGTC_1286 0929-0070 131 µM 0.0376649093046603 0.491675284236952 no 1646 0.484977427225447 2298 1420408
SGTC_79 0052-0007 94.094 µM 0.036672167755389 0.492074727108838 no 1647 0.485373200311971 2335 2801472
SGTC_1930 st074634 34.3 µM 0.0350797222499235 0.492715485338164 no 1648 0.486008085379775 2344 684253 YOR116C RPO31
SGTC_3246 9135460 32.98 µM 0.0344418566500404 0.492972151060527 no 1649 0.486262403238329 2339 41446951
SGTC_1772 st048439 82.2 µM 0.0341543529303053 0.49308783837892 no 1650 0.486377033184635 2261 2927068 YDL195W SEC31
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0339048688305752 0.493188227626262 no 1651 0.486476505328282 2334 364106
SGTC_2938 9059746 27.26 µM 0.0337318097534734 0.493257864664596 no 1652 0.486545506442176 2309 6471769
SGTC_2826 7992541 19.48 µM 0.0318820225359266 0.494002210773031 no 1653 0.487283067644829 2362 2985066
SGTC_3067 9117431 49.47 µM 0.0313050812195839 0.494234373774061 no 1654 0.487513119084173 2319 17150885
SGTC_1403 3909-7815 62.9 µM 0.0301383757008331 0.494703865631596 no 1655 0.487978347619127 2326 6615483
SGTC_3108 9121785 49.47 µM 0.0289112272619289 0.495197688118994 no 1656 0.488467695652813 2363 17140271
SGTC_1978 st071761 42 µM 0.0275917322512985 0.495728680407436 no 1657 0.488993887932109 2223 5147680
SGTC_487 nimodipine 119 µM 0.0270688511688395 0.495939100796995 no 1658 0.489202409409584 2363 4497 L-type voltage-gated calcium channels inhibitor
SGTC_233 rapamycin 362 pM 0.0267062515560398 0.496085020592258 no 1659 0.489347013445696 2357 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1280 0880-0253 10.1 µM 0.0266652182575407 0.496101533523875 no 1660 0.489363377535666 2340 6836607
SGTC_322 k048-0136 19.3 µM 0.0263512574736078 0.49622788022598 no 1661 0.489488585767444 2308 6823282
SGTC_1151 3909-8316 15.3 µM 0.0254834828822943 0.496577099202231 no 1662 0.48983466148013 2297 800431
SGTC_1731 st035964 63 µM 0.0253967353328556 0.496612009211907 no 1663 0.489869257548226 2187 6739575
SGTC_1276 0871-0068 94.2 µM 0.0230841927688883 0.497542659592242 no 1664 0.490791557335236 2359 3414906
SGTC_2053 5265679 138 µM 0.0228935173680656 0.497619394903849 no 1665 0.490867605716378 2369 764595
SGTC_1921 5740136 50 µM 0.0224081862246203 0.497814711713893 no 1666 0.491061175164749 2358 1774243
SGTC_1689 st020265 53.493 µM 0.0221539498267912 0.497917026897657 no 1667 0.491162575639734 2370 5758320 YPR016C TIF6
SGTC_1954 st077032 68.9 µM 0.0220727067322852 0.497949722489793 no 1668 0.49119497902153 2212 698907
SGTC_995 3931-2021 34.6 µM 0.0212929121766779 0.498263544842348 no 1669 0.491505998911213 2330 730143
SGTC_1100 amiodarone 5.07 µM 0.0199271372888509 0.49881319296806 no 1670 0.492050748507368 2386 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3221 9128209 49.47 µM 0.0196901198856348 0.49890857949617 no 1671 0.492145286221223 2364 16460723
SGTC_1003 4049-0218 100 µM 0.0194689886154901 0.498997572781855 no 1672 0.492233487926147 2353 295161
SGTC_3303 9125618 40.5795 µM 0.019145794228311 0.499127640998722 no 1673 0.492362399801595 2344 22695467
SGTC_1238 0333-0287 48.8 µM 0.0191126273777904 0.499140988863192 no 1674 0.492375629039888 2365 7226
SGTC_474 dl-dihydrosphingosine 5 µM 0.0189273727489091 0.499215543854473 no 1675 0.492449521576977 2366 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_723 4182-0001 115 µM 0.0185460801942232 0.499368993615485 no 1676 0.49260160859877 2340 744821 YLR208W SEC13
SGTC_174 3553-0389 74.3 µM 0.0169781549330444 0.5 no 1677 0.493227021549481 2353 738071
SGTC_70 0141-0289 43.283 µM 0.016275352145084 0.499717159226273 no 1678 0.493507360538229 2287 352408
SGTC_2508 celastrol 40.54 µM 0.0161165476164805 0.49965324885733 no 1679 0.493570706070351 2381 122724 Celastrol is a natural product and antioxidant.
SGTC_2721 ifenprodil 61.44 µM 0.0159198634934312 0.499574093980626 no 1680 0.493649161616971 2364 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1422 4031-0024 15.5 µM 0.0154581843785701 0.499388292814726 no 1681 0.493833322267682 2381 782427
SGTC_2094 5332512 191.667 µM 0.0143193624499508 0.498929978512716 no 1682 0.494287596106814 2377 755774
SGTC_2440 5628896 157.78 µM 0.014070887326726 0.498829980866085 no 1683 0.494386713352198 2370 5522048
SGTC_1144 3486-0183 12.5 µM 0.0139852357551867 0.498795510810013 no 1684 0.494420880023522 2368 6744069
SGTC_3054 9094397 49.47 µM 0.0138523976502432 0.498742050782229 no 1685 0.494473869626815 2380 2598354
SGTC_1442 4112-3290 3 µM 0.0138474729516361 0.498740068862451 no 1686 0.494475834108885 2380 704353
SGTC_2254 7938975 95.19 µM 0.0133658266341545 0.498546232922153 no 1687 0.494667965400766 2384 2969277
SGTC_2557 derrustone 83.84 µM 0.012338459164232 0.49813277567732 no 1688 0.495077791855536 2332 629853 An antioxidant.
SGTC_552 k242-0005 476 µM 0.012285263735736 0.498111367579665 no 1689 0.495099012152717 2372 4088318
SGTC_2109 5483026 200 µM 0.0120454833281871 0.498014869837526 no 1690 0.495194663616777 2376 759335
SGTC_2923 7992654 58.14 µM 0.0119838934716554 0.497990083501923 no 1691 0.495219232641221 2381 2985126
SGTC_3282 9108498 15.4605 µM 0.0117997196675982 0.497915964302765 no 1692 0.495292702163466 2369 16459645
SGTC_496 calpeptin 138 µM 0.0101282904464317 0.497243315267499 no 1693 0.495959465794044 2333 73364 A calpain inhibitor.
SGTC_2875 9039966 71.43 µM 0.00982366364706982 0.497120722217953 no 1694 0.496080988256468 2362 6463691
SGTC_1091 telmisartan 47.6 µM 0.0085166538212636 0.496594736530862 no 1695 0.496602387776595 2365 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1800 st050079 29.0735 µM 0.00739927394380612 0.496145069112786 no 1696 0.49704814371489 2379 3645560
SGTC_1227 3909-8010 46.6 µM 0.00716674608772953 0.496051493475688 no 1697 0.497140906447637 2389 15982272
SGTC_1590 st077108 57.8 µM 0.00652563819968955 0.495793495080131 no 1698 0.497396665492267 2393 5489485
SGTC_2133 5320837 200 µM 0.00643628191587525 0.495757535937684 no 1699 0.497432312743237 2389 2841355
SGTC_536 3852-0578 10.6 µM 0.00547696552685749 0.495371485915986 no 1700 0.497815017806915 2401 2869208
SGTC_1338 1486-1223 76 µM 0.00534049150719058 0.495316566111572 no 1701 0.497869462267119 2377 3444526
SGTC_1998 st075797 76.8 µM 0.00499802133500613 0.49517874983516 no 1702 0.498006086272521 2397 24208315
SGTC_2896 9052656 71.43 µM 0.00434205203480298 0.494914777382311 no 1703 0.498267777302668 2393 6469436
SGTC_3133 9127736 49.47 µM 0.00352809714785672 0.494587232131564 no 1704 0.498592495798334 2397 27243420
SGTC_107 0358-0022 2.6945 µM 0.00346668775111032 0.494562520395906 no 1705 0.498616994453275 2386 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_602 3130-1533 38.1 µM 0.00322771505861659 0.494466355670793 no 1706 0.498712330229885 2400 720941
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.00123253410279366 0.493663490291532 no 1707 0.499508290158855 2404 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2011 4012611 177 µM -0.000308919839494352 0.49304322310657 no 1708 0.499876758816731 2407 2049887
SGTC_2268 7933382 153.85 µM -0.000641248035466375 0.492909499385918 no 1709 0.49974417906396 2405 935025 YOR257W CDC31
SGTC_1177 0983-0204 23.6 µM -0.00105759745357593 0.492741967952636 no 1710 0.499578079738777 2409 766818
SGTC_18 0111-0177 500 nM -0.00226943977955606 0.492254352034745 no 1711 0.499094625296277 2409 721752
SGTC_1252 0493-0875 34.8 µM -0.00244903806437192 0.492182087014323 no 1712 0.499022976146473 2413 3960963
SGTC_2135 5326629 150.42 µM -0.00247732542540493 0.492170705042969 no 1713 0.499011691156391 2408 5020077
SGTC_883 0850-0245 24.6 µM -0.00314107473484285 0.491903634413858 no 1714 0.498746894542967 2432 6823229 YPR165W RHO1
SGTC_501 nsc-95397 161 µM -0.00320386439210732 0.491878370131777 no 1715 0.498721845219972 2415 262093
SGTC_2250 alverine citrate 130 µM -0.00572712832494269 0.490863128245643 no 1716 0.497715218856039 2408 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.00585183066201224 0.490812955412894 no 1717 0.497665470655088 2417 16623 A steroid.
SGTC_1740 st038286 13.222 µM -0.00602297486521791 0.490744097361351 no 1718 0.497597195199927 2420 716786
SGTC_562 3772-2733 112 µM -0.00747215884912437 0.490161044846381 no 1719 0.497019067648379 2422 2876874 YIL048W NEO1
SGTC_2437 5741531 144.16 µM -0.00763857777209222 0.490094090576602 no 1720 0.496952677998731 2422 2262990
SGTC_905 2-aminofluorene 215 µM -0.00840853422449431 0.489784322543359 no 1721 0.49664551971058 2419 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2835 9006588 71.43 µM -0.00841139313259604 0.489783172361961 no 1722 0.496644379211596 2447 2345538
SGTC_1844 rapamycin 4 nM -0.00862821551255452 0.48969594173078 no 1723 0.496557882736382 2418 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2767 sibutramine 71.45 µM -0.00872128061415344 0.489658500508936 no 1724 0.496520756529461 2423 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_537 1334-0398 209 µM -0.00901775361166612 0.489539226426725 no 1725 0.49640248556837 2423 5846986
SGTC_477 mead ethanolamide 10 µM -0.00935482842100632 0.489403618962415 no 1726 0.496268017849749 2422 16061185
SGTC_59 0330-0160 1.33 µM -0.0104899696508791 0.488946953105401 no 1727 0.495815184335422 2434 4293482
SGTC_2069 5228469 200 µM -0.0109350309592029 0.488767909434618 no 1728 0.495637640751162 2431 2835210
SGTC_1020 4335-0961 93.3 µM -0.0110867726401142 0.48870686580406 no 1729 0.495577108248596 2424 669075
SGTC_532 1548-0774 215 µM -0.0114374978464076 0.488565774801181 no 1730 0.495437198008807 2438 5932993
SGTC_3337 9144342 33.5465 µM -0.0115154590430628 0.488534412483147 no 1731 0.495406098039387 2441 17682949
SGTC_2626 ethyl orsellinate 100 µM -0.0116894014203289 0.48846443900347 no 1732 0.495336709741388 2442 75653 A natural product.
SGTC_1514 1189-1591 158 µM -0.0125631629031706 0.48811294795022 no 1733 0.494988154981842 2432 767698 YMR146C TIF34
SGTC_1710 st031758 61.5 µM -0.0127619457110085 0.488032984182051 no 1734 0.494908858472776 2435 5394341
SGTC_786 4544-0069 423 µM -0.0130594801208981 0.487913296800901 no 1735 0.494790169309588 2480 748821 YLR208W SEC13
SGTC_2746 daunorubicin 9.88 µM -0.0130936656558636 0.487899545260461 no 1736 0.494776532420295 2425 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2322 7413319 38.22 µM -0.0132130018043983 0.487851540979833 no 1737 0.494728928303269 2444 1840400
SGTC_3062 9077494 49.47 µM -0.0136360465794301 0.487681367980495 no 1738 0.494560173064303 2421 16459633
SGTC_781 4335-2806 94.4 µM -0.0139127085244487 0.487570079806208 no 1739 0.494449811387557 2466 845254
SGTC_2217 6934799 96.0675 µM -0.0148220006871549 0.487204320917724 no 1740 0.494087093749289 2429 675606
SGTC_1934 st074720 32.6 µM -0.0148779621407704 0.48718181101047 no 1741 0.494064770820856 2428 17250992
SGTC_907 3448-6986 75.5 µM -0.015214423234039 0.487046473931134 no 1742 0.493930557458675 2436 590582
SGTC_2917 7979103 53.79 µM -0.0162995937657675 0.486609988504351 no 1743 0.493497690813479 2438 2980565
SGTC_2679 rapamycin 1 nM -0.016407098676556 0.486566747937872 no 1744 0.493454808293696 2440 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2165 5727197 32.143 µM -0.0174819755983423 0.486134420297067 no 1745 0.493026056019529 2523 1361712
SGTC_302 1094-0063 18.9 µM -0.0190506909948502 0.485503494628522 no 1746 0.492400333583742 2456 5440289
SGTC_1224 0823-0416 294 µM -0.0195589098663811 0.485299100483295 no 1747 0.492197621366811 2455 3598164
SGTC_2483 5729050 27.16 µM -0.0196390909072974 0.485266853831965 no 1748 0.492165639902475 2453 2865180
SGTC_109 0132-0036 33.701 µM -0.0199622024394848 0.485136908070014 no 1749 0.492036762318271 2433 67274 A color developer.
SGTC_1206 3978-0017 132 µM -0.0203418537668044 0.484984225717026 no 1750 0.491885334103843 2527 3873677
SGTC_716 1683-5115 658 µM -0.0203999980660077 0.484960842327623 no 1751 0.491862142696952 2435 723597
SGTC_3050 9093513 49.47 µM -0.020887187541376 0.484764915594219 no 1752 0.4916678236283 2447 25236664
SGTC_2158 5657123 3.6195 µM -0.0211205768750221 0.48467105770392 no 1753 0.491574735291358 2444 2858827
SGTC_282 k297-0036 65.7 µM -0.0211756395656732 0.484648914279264 no 1754 0.491552773367689 2439 5061378
SGTC_2070 5230947 200 µM -0.0213096301350041 0.48459503025826 no 1755 0.491499330923747 2433 2835538
SGTC_1296 1068-0102 11.9 µM -0.0213177819452067 0.484591752034282 no 1756 0.491496079560584 2460 767053
SGTC_2086 5274770 176.623 µM -0.0217227051413878 0.484428914802268 no 1757 0.491334575980586 2455 689278
SGTC_1497 4476-2978 41.3 µM -0.0219995741254419 0.484317575232703 no 1758 0.491224147627596 2496 1528379
SGTC_2586 curcumin 80 µM -0.0226928476401224 0.484038788915967 no 1759 0.490947640562198 2460 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3149 9097855 49.47 µM -0.0233469200162054 0.483775773717506 no 1760 0.49068677256968 2461 25236625 YMR079W SEC14
SGTC_2974 9094440 9.66 µM -0.0236491250591047 0.483654253581194 no 1761 0.490566243481263 2611 25236134
SGTC_316 k060-0003 58.6 µM -0.0272864784101422 0.482191754177475 no 1762 0.489115620759905 2492 6152314
SGTC_2151 5563267 85.4165 µM -0.0277834564860754 0.481991948441791 no 1763 0.488917430340719 2466 5310824
SGTC_991 3996-0057 64.7 µM -0.0286745485078515 0.481633703963034 no 1764 0.488562077683572 2485 715343
SGTC_3255 9139072 49.47 µM -0.029162549222174 0.481437519985032 no 1765 0.488367474956132 2499 17646060
SGTC_2061 5245884 80.95 µM -0.0298939108007858 0.481143509535948 no 1766 0.488075831078914 2471 573863
SGTC_1241 0364-0022 50.8 µM -0.0302169290315816 0.481013658096316 no 1767 0.487947023640709 2496 4563895
SGTC_1285 0929-0069 65.5 µM -0.030394384631959 0.480942322839257 no 1768 0.487876261601469 2488 1206237
SGTC_1974 st069448 26.9 µM -0.0305974810900621 0.480860680980134 no 1769 0.487795275504841 2464 6323587 YNR016C ACC1
SGTC_1379 2144-0755 36.5 µM -0.0321001888372715 0.480256639219313 no 1770 0.487196076409385 2471 5392327
SGTC_298 1391-0729 10 µM -0.0323837125302349 0.480142676557456 no 1771 0.48708302559703 2460 3237558
SGTC_3198 9112019 49.47 µM -0.0338140585252343 0.479567772342946 no 1772 0.486512712637441 2478 45595555
SGTC_1137 ixabepilone 100 µM -0.0339398542204379 0.47951721283357 no 1773 0.486462556205193 2466 154225 A novel microtubule stabilizer.
SGTC_2024 5144227 134 µM -0.0348720643085083 0.479142551475947 no 1774 0.486090878256022 2486 3475211
SGTC_2420 aureobasidin a 50 nM -0.0353705831584413 0.478942201017204 no 1775 0.485892120633571 2533 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1675 st018485 24.5 µM -0.0354795273959894 0.478898417967319 no 1776 0.485848685433747 2525 3323024
SGTC_1274 0865-0114 173 µM -0.0368391985286468 0.478352008186553 no 1777 0.485306609670983 2497 870624
SGTC_358 0075-0058 9.45 µM -0.0370162161456558 0.478280873252003 no 1778 0.485236037993413 2456 1069125
SGTC_509 pifithrin 175 µM -0.0376267935539921 0.478035516646285 no 1779 0.484992622438715 2472 4817 A p53 inhibitor.
SGTC_2536 dehydroabietamide 32.04 µM -0.0388616837557587 0.477539309499219 no 1780 0.484500332705354 2510 3983547
SGTC_2241 6772625 37.8075 µM -0.0391056296923916 0.477441290532742 no 1781 0.484403086279358 2461 2285411
SGTC_67 0335-0847 266 µM -0.0393686949949397 0.477335590817824 no 1782 0.484298219163387 2583 4552207 YOR254C SEC63
SGTC_589 1227-0070 34.1 µM -0.0393726765046143 0.477333991058311 no 1783 0.484296632001405 2513 2841384
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.0406717933226658 0.476812029185986 no 1784 0.483778774324869 2499 688801
SGTC_648 0375-0473 33.3 µM -0.0409271616582538 0.476709431412218 no 1785 0.483676981856008 2484 1713139
SGTC_1212 0520-0165 585 µM -0.0417247262624888 0.476389008732601 no 1786 0.483359071207635 2533 5403258
SGTC_2118 5526350 200 µM -0.0419978517750034 0.476279283680017 no 1787 0.483250205321497 2554 743594
SGTC_2845 9003024 42.97 µM -0.0419985778792897 0.476278991978314 no 1788 0.483249915903155 2542 2990173
SGTC_932 2857-0803 154 µM -0.0432409732841101 0.475779896670866 no 1789 0.482754721829778 2665 674898
SGTC_2387 9077560 195.08 µM -0.0434218730904863 0.475707228718415 no 1790 0.482682620969108 2467 5303272
SGTC_1683 st010134 710 nM -0.04372367381649 0.475585996331902 no 1791 0.4825623341414 2487 3818134
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0440912398235441 0.475438349295948 no 1792 0.482415837801819 2492 3256 An antibiotic and ribosome inhibitor.
SGTC_2271 7849410 118.62 µM -0.0464719858391576 0.474482113575795 no 1793 0.481467031008264 2470 972430
SGTC_2658 polymyxin b sulfate 77.05 µM -0.046991493661683 0.474273470623087 no 1794 0.481260003557668 2516 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1428 4049-0204 61.7 µM -0.0470533764944405 0.474248617920896 no 1795 0.481235343157751 2517 X1428
SGTC_2921 7974240 10.71 µM -0.050521195127843 0.472856073757981 no 1796 0.479853529850137 2523 2979074 YDR527W RBA50
SGTC_159 3970-0959 50 µM -0.0508403235858266 0.472727940305968 no 1797 0.479726379416257 2545 6615653
SGTC_2803 7707263 71.43 µM -0.0509393230520795 0.472688191545832 no 1798 0.479686935452009 2513 2199229
SGTC_3307 9126885 69.2785 µM -0.0529291710907377 0.471889316226936 no 1799 0.47889417089845 2488 24824909
SGTC_491 tetrandrine 80.3 µM -0.0536967056103199 0.471581199936065 no 1800 0.478588403779591 2519 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_686 1319-0111 510 µM -0.0537844121489923 0.471545992418697 no 1801 0.478553464422768 2513 4562600
SGTC_2676 harmalol 100 µM -0.0560284649357497 0.470645251966968 no 1802 0.477659565516105 2496 5459187 A monoamine oxidase inhibitor
SGTC_1200 1643-0193 18.4 µM -0.0563338551595474 0.470522682876809 no 1803 0.477537924564892 2483 5403974
SGTC_230 MPP+ 141.667 µM -0.0577920281099722 0.469937480407872 no 1804 0.476957144107003 2532 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_415 dibenzyl ketone 100 µM -0.0589055537552467 0.469490637458643 no 1805 0.47651366723913 2608 7593
SGTC_1047 2043-3044 82 µM -0.0589628922557624 0.4694676293206 no 1806 0.476490832177292 2512 669592
SGTC_2466 5983409 37.09 µM -0.0592845873950602 0.469338545065224 no 1807 0.476362718499325 2562 2879657
SGTC_2281 7943571 200 µM -0.0594761487240417 0.469261680182026 no 1808 0.47628643120023 2533 1244024
SGTC_2998 9066762 71.4286 µM -0.0604233886480426 0.468881612605709 no 1809 0.475909215619988 2551 4945196
SGTC_3004 9076122 71.4286 µM -0.0609142641341863 0.468684666398289 no 1810 0.475713744702872 2545 44782551
SGTC_1903 st060211 78.3 µM -0.0618803533866097 0.468297080114698 no 1811 0.475329056617888 2514 688960
SGTC_372 0155-0182 15.9 µM -0.062092509841824 0.468211968871901 no 1812 0.475244580885296 2519 771486
SGTC_2504 purpurogallin 52.29 µM -0.0633437737173455 0.467710026445109 no 1813 0.474746379671565 2559 5281571 An antioxidant.
SGTC_1931 st074438 57.1 µM -0.0639951554389486 0.467448746016248 no 1814 0.474487042151108 2498 2787313
SGTC_3011 9081274 71.4286 µM -0.0657380445232538 0.466749712452575 no 1815 0.473793191379127 2556 6625322
SGTC_1946 st076057 65.1 µM -0.0657515442691688 0.46674429840594 no 1816 0.47378781738648 2527 953009
SGTC_2959 9079155 11 µM -0.0658572411572546 0.466701909088947 no 1817 0.473745741626235 2620 16189457
SGTC_1879 gemcitabine 100 µM -0.0659959597905989 0.466646277105414 no 1818 0.473690521031941 2528 60750 A nucleoside analog which inhibits DNA replication.
SGTC_520 3584-0023 682 µM -0.0675735337353059 0.466013649968368 no 1819 0.473062562124514 2612 1340790
SGTC_380 3970-0968 6 µM -0.0680421024287268 0.465825764454218 no 1820 0.472876059516554 2542 2891601
SGTC_444 curcumin 90.4 µM -0.068452695036956 0.46566113230723 no 1821 0.472712637795048 2588 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2168 5727979 200 µM -0.0684690054704248 0.465654592559867 no 1822 0.472706146104278 2518 695210
SGTC_3166 9102297 49.47 µM -0.068755430725508 0.465539750478576 no 1823 0.472592147608029 2562 25237072
SGTC_3245 9134821 49.47 µM -0.0688772634789774 0.46549090255854 no 1824 0.472543658322705 2526 17014901
SGTC_3043 9092303 49.47 µM -0.068894910169097 0.465483827294844 no 1825 0.472536634995564 2538 25236084
SGTC_3031 9088762 49.47 µM -0.0692071180462549 0.465358652479012 no 1826 0.472412378656739 2513 205253
SGTC_3333 9141820 12.094 µM -0.0699893452639404 0.465045045913357 no 1827 0.472101070044477 2574 1939433
SGTC_3137 9097352 49.47 µM -0.0702683401726332 0.464933197933117 no 1828 0.471990040540286 2609 44120435
SGTC_3263 9137018 49.47 µM -0.0703160052194214 0.464914089477 no 1829 0.471971071857791 2536 43844957
SGTC_916 4466-0038 42 nM -0.0708128695061508 0.464714906217277 no 1830 0.471773344577194 2542 5722064 YGL116W CDC20
SGTC_343 4130-2827 29.8 µM -0.0711953378625414 0.464561588088033 no 1831 0.47162114592486 2564 1118244
SGTC_1384 3089-0840 101 µM -0.0722930819595815 0.464121570340725 no 1832 0.47118433504461 2511 1069836
SGTC_1631 benzylvanillin 81.9 µM -0.0727298769925228 0.463946498387702 no 1833 0.47101053654943 2647 75506
SGTC_255 tunicamycin 200.472 nM -0.0732132225533377 0.463752776641071 no 1834 0.470818222275308 2545 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_163 TUB2.036 7.546 µM -0.074296471120601 0.463318648965274 no 1835 0.470387242455403 2531 15992207 YJR013W GPI14
SGTC_2461 5755302 26.15 µM -0.0749387700798897 0.463061258876196 no 1836 0.470131714601988 2581 2788904
SGTC_97 0535-0701 19.132 µM -0.0768617358157863 0.462290756821244 no 1837 0.46936676892809 2563 2832013 YGL099W LSG1
SGTC_1519 esterone 74 µM -0.077050379403716 0.462215177883295 no 1838 0.469291733542922 2544 698 A steroid.
SGTC_1644 st010134 20.9 µM -0.0781252967981543 0.46178454470157 no 1839 0.468864192377187 2558 3818134
SGTC_1377 2944-0135 198 µM -0.0791225773712046 0.46138505441718 no 1840 0.468467562831188 2602 1894137
SGTC_344 k064-0035 6.43 µM -0.0803782665643416 0.460882106363562 no 1841 0.467968205868884 2551 5088750
SGTC_2097 5376186 200 µM -0.0807226476739709 0.460744180414852 no 1842 0.467831262675258 2567 742755
SGTC_1087 pterostilbene 9.05 µM -0.0815724094051876 0.460403867836037 no 1843 0.467493371130605 2624 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1315 1237-0019 3.69 µM -0.0826331257472052 0.459979112877204 no 1844 0.467071630400652 2559 825140
SGTC_717 1532-0246 73.2 µM -0.0834146384495627 0.459666191865472 no 1845 0.466760924638304 2599 9561992
SGTC_726 3448-4391 34.2 µM -0.0836952710984374 0.459553831444997 no 1846 0.466649358535779 2664 1356692
SGTC_744 1594-0068 283 µM -0.0838056773673915 0.459509627584524 no 1847 0.466605467008035 2560 668392
SGTC_1052 3253-3998 198 µM -0.0847815535862452 0.459118933407264 no 1848 0.46621752941887 2546 5450317
SGTC_2117 5521686 200 µM -0.0850904873834417 0.458995259296005 no 1849 0.466094726423897 2566 803312
SGTC_2177 5811945 192 µM -0.0859273767935411 0.458660251001817 no 1850 0.465762074229018 2657 5343475
SGTC_1430 4049-0248 69.1 µM -0.0864555431588055 0.458448840178414 no 1851 0.465552147556517 2597 22774488
SGTC_2342 7990637 118.86 µM -0.0869404127950668 0.458254770219606 no 1852 0.465359438176509 2628 2033102 YER133W GLC7
SGTC_422 cantharidin 155 µM -0.0875812494698666 0.457998289442931 no 1853 0.465104752829373 2549 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1178 0988-0033 191 µM -0.088291726812229 0.45771395696836 no 1854 0.464822407162239 2671 5392207
SGTC_540 1187-0821 17.3 µM -0.0883164753945227 0.457704052994354 no 1855 0.46481257232536 2581 847520
SGTC_1936 st074407 74.3 µM -0.0887310122578728 0.457538166095179 no 1856 0.464647842758889 2561 809813
SGTC_2071 5230951 39.92 µM -0.0899384870075934 0.457055008282925 no 1857 0.46416804842938 2566 1799272
SGTC_2973 9094665 17.96 µM -0.0899494242244971 0.457050632164222 no 1858 0.464163702724917 2788 25237061 YIL048W NEO1
SGTC_631 k072-0230 41.5 µM -0.0904373875265882 0.456855397187713 no 1859 0.463969823728604 2655 5773147
SGTC_965 1291-5240 308 µM -0.0908429099980863 0.456693154853814 no 1860 0.463808706870167 2617 2834598
SGTC_682 0kpi-0099 17 µM -0.0908524486795565 0.456689338683673 no 1861 0.463804917157959 2642 1714895 YML126C ERG13
SGTC_2021 4019055 173 µM -0.0918971249257323 0.456271416040167 no 1862 0.463389887887074 2668 44827708 YER133W GLC7
SGTC_804 1595-0054 20.9 µM -0.0923481547836481 0.456090996506846 no 1863 0.46321071490686 2579 761523 Stimulates phospholipase C.
SGTC_1790 st045711 43.5 µM -0.09307408097432 0.455800632841367 no 1864 0.46292235421084 2580 585119
SGTC_2859 9028643 45.46 µM -0.0936309919931863 0.45557788965209 no 1865 0.462701144851055 2673 17151580
SGTC_3184 9108758 49.47 µM -0.0946160543456691 0.455183936475822 no 1866 0.462309898760702 2539 902885
SGTC_624 k048-0052 28 µM -0.0955764729135576 0.454799881442956 no 1867 0.461928475767874 2627 6835531
SGTC_2709 st078560 56 µM -0.0962252094478317 0.454540486632671 no 1868 0.461670854734653 2610 17250903
SGTC_2479 5617353 43.85 µM -0.0965808219230034 0.454398304569548 no 1869 0.461529643586352 2667 2731746
SGTC_813 k007-0158 173 µM -0.0966158118693183 0.454384315098067 no 1870 0.461515749592894 2638 6523916
SGTC_705 1124-0212 310 µM -0.0987124840936949 0.453546140023722 no 1871 0.460683278203448 2569 9554485
SGTC_2906 7926292 26.41 µM -0.101452636887733 0.452451036700082 no 1872 0.459595576892121 2684 2966319
SGTC_2423 st077119 87.2 µM -0.102777282488366 0.451921770619658 no 1873 0.459069867857601 2532 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.1032611849483 0.451728447212139 no 1874 0.458877840407088 2634 688798
SGTC_2620 irigenin 100 µM -0.103794819424547 0.451515268687841 no 1875 0.458666088882254 2672 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1299 1079-1439 3.74 µM -0.103991531342916 0.451436688914542 no 1876 0.458588034570851 2608 323161
SGTC_588 3970-1144 52.9 µM -0.104932421975232 0.451060861228374 no 1877 0.458214715980055 2712 1888707
SGTC_1718 roemerine 11.9335 µM -0.105775151772797 0.450724279963358 no 1878 0.45788037609044 2624 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3159 9100096 49.47 µM -0.106424251529219 0.450465057526877 no 1879 0.457622876201481 2552 25236875
SGTC_1889 st059080 5.18 µM -0.106546079417418 0.450416407076466 no 1880 0.457574548679233 2577 176925 Isolated from Daphnopsis sellowiana.
SGTC_1305 1181-0477 144 µM -0.107274488740077 0.450125541451429 no 1881 0.457285611385719 2710 6252086
SGTC_1886 st057356 49.9 µM -0.108305536764718 0.449713873129866 no 1882 0.456876665375423 2591 24207747
SGTC_575 k072-0246 11.9 µM -0.110771127460451 0.448729652726346 no 1883 0.45589892068388 2605 6796779
SGTC_2002 4023503 131 µM -0.111263217968598 0.448533256425902 no 1884 0.455703811033585 2604 4736863 YCR052W RSC6
SGTC_3106 9121286 49.47 µM -0.112355792282899 0.448097248560545 no 1885 0.455270652979725 2810 15943471
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.112993264082135 0.447842884981385 no 1886 0.45501794774863 2629 6708514
SGTC_2253 7938677 135.83 µM -0.1138566815103 0.447498398939851 no 1887 0.454675702667357 2810 2301972
SGTC_270 tamoxifen 5.46 µM -0.116626900936349 0.446393406196675 no 1888 0.453577859664401 2655 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1464 k208-0027 110 µM -0.116640358777394 0.446388039104828 no 1889 0.453572527156364 2656 X1464
SGTC_3038 9091290 49.47 µM -0.117591028487115 0.44600892952771 no 1890 0.453195856927318 2669 25236843
SGTC_3259 9138485 49.47 µM -0.117693671740846 0.445968000233776 no 1891 0.453155190575034 2670 17646153
SGTC_64 000l-0018 272.079 µM -0.118660439361737 0.445582527161041 no 1892 0.452772189928436 2621 6811119
SGTC_704 1310-0270 142 µM -0.119168675143094 0.445379902162122 no 1893 0.452570861691312 2690 5718033
SGTC_129 0088-0017 176.636 µM -0.119415855411583 0.445281360728785 no 1894 0.452472950187891 2625 182446
SGTC_1452 4194-0072 190 µM -0.119892084223639 0.445091515832427 no 1895 0.452284317559652 2778 1343545
SGTC_576 1073-0113 22.7 µM -0.120188167211653 0.444973491007276 no 1896 0.452167045512244 2648 5439563
SGTC_1010 4112-3296 15.2 µM -0.120437269439945 0.444874197465978 no 1897 0.452068384756412 2672 704384
SGTC_630 4356-0227 183 µM -0.120483820585885 0.444855642302261 no 1898 0.45204994778958 2624 779312
SGTC_1255 0566-0045 221 µM -0.121062923062573 0.44462482369984 no 1899 0.451820598115413 2735 2788469
SGTC_653 0203-0016 55.2 µM -0.121401127024206 0.444490031081426 no 1900 0.451686662123917 2696 295302
SGTC_1714 st033236 13.627 µM -0.121561313727763 0.444426190233039 no 1901 0.451623226686539 2735 2916566
SGTC_1961 st076550 68.7 µM -0.122126509899415 0.444200948340169 no 1902 0.451399413579145 2736 1579337
SGTC_1812 st052057 4.327 µM -0.12268034307516 0.44398025230706 no 1903 0.451180115111179 2610 3645418
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.122809555699115 0.44392876508661 no 1904 0.451128953595628 2614 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2986 9022445 71.43 µM -0.122965984666396 0.443866434264485 no 1905 0.451067016902332 2660 6459286
SGTC_3338 9144300 39.5675 µM -0.123102332702922 0.443812106040042 no 1906 0.451013032051186 2684 4901274
SGTC_1174 0739-0097 51.1 µM -0.123317111821549 0.443726528892181 no 1907 0.450927995490317 2671 728447
SGTC_650 1328-0195 38 µM -0.12377179617048 0.443545371946102 no 1908 0.450747981732219 2611 2780821
SGTC_154 3389-1638 511.116 µM -0.12511849109113 0.44300888635535 no 1909 0.45021487227791 2732 5238686
SGTC_2694 st077685 81.9 µM -0.125537831870961 0.442841854000418 no 1910 0.450048888212551 2617 2838096
SGTC_2813 7971799 71.43 µM -0.125799458900366 0.442737647531987 no 1911 0.449945335053235 2738 2234054
SGTC_1620 st003704 16.5 µM -0.126501336163561 0.442458108271943 no 1912 0.4496675457192 2648 2834414
SGTC_3049 9092223 49.47 µM -0.12663291406411 0.442405707437952 no 1913 0.449615472493042 2736 8623917
SGTC_1226 3909-7979 35.4 µM -0.127156909833258 0.44219703638694 no 1914 0.449408104718311 2750 6615510
SGTC_547 1120-0019 610 nM -0.12789965077643 0.441901281846325 no 1915 0.449114193708539 2620 3676939
SGTC_1015 4130-4525 82 µM -0.128948326517911 0.441483761267827 no 1916 0.44869926840611 2653 1363237
SGTC_2171 5739187 198.077 µM -0.129060069240961 0.441439275757792 no 1917 0.448655058913189 2613 2262761
SGTC_446 go6976 132 µM -0.129313629908262 0.441338334336105 no 1918 0.448554743439589 2704 3501 A protein kinase C inhibitor.
SGTC_73 0327-0325 16.231 µM -0.129579819016267 0.441232369685766 no 1919 0.448449435351601 2812 53298
SGTC_1161 k007-0610 110 µM -0.131625003499918 0.440418362835539 no 1920 0.447640453828969 2710 5843850
SGTC_912 3474-0017 2.18 µM -0.131793589930201 0.440351274689044 no 1921 0.447573778409996 2784 3360550
SGTC_2533 agelasine 13.65 µM -0.132153393560579 0.440208098321117 no 1922 0.447431482128731 2724 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1623 st003709 20.3 µM -0.132763200106963 0.439965456357918 no 1923 0.447190329361603 2628 16192618
SGTC_84 0443-0269 128.823 µM -0.133202035225568 0.439790857853908 no 1924 0.447016800657175 2637 6150058
SGTC_1149 3909-7961 23.3 µM -0.133602917479435 0.439631369818239 no 1925 0.446858288529957 2663 735261
SGTC_2963 9082507 9 µM -0.133649119010259 0.43961298951052 no 1926 0.446840020611299 2767 16459611
SGTC_2788 5282734 71.43 µM -0.133677779738031 0.439601587507945 no 1927 0.446828688319595 2759 743706
SGTC_669 0108-0021 26.2 µM -0.133701417146127 0.439592183953727 no 1928 0.446819342253107 2593 17201
SGTC_1873 rapamycin 2 nM -0.135223825055393 0.438986603899228 no 1929 0.446217455214036 2660 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2648 atorvastatin 78.68 µM -0.136410932675178 0.438514497855713 no 1930 0.445748215720728 2690 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2794 7785382 27.27 µM -0.136918353096558 0.43831272624733 no 1931 0.445547665892158 2621 2205081
SGTC_1027 k015-0025 8.67 µM -0.137674354096555 0.438012138346922 no 1932 0.445248894412827 2632 3598955
SGTC_3083 9117465 49.47 µM -0.137723958015313 0.437992416952334 no 1933 0.445229292036978 2736 16420915
SGTC_549 1661-1316 519 µM -0.137950331448785 0.437902417958342 no 1934 0.445139835944184 2706 2857282
SGTC_1694 st024011 44.9 µM -0.138263204508763 0.437778034707954 no 1935 0.44501620235414 2673 2787533
SGTC_1314 1222-0010 41.1 µM -0.142049907461612 0.436273115132347 no 1936 0.44352029244261 2709 3526027
SGTC_2685 mycophenolic acid 18.85 µM -0.142304707324902 0.436171884893268 no 1937 0.443419664230388 2710 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2646 retinol 96.75 µM -0.142380878846038 0.436141623281514 no 1938 0.443389582489109 2736 445354 A vitamin A analog and teratogen.
SGTC_529 4076-0302 30.3 µM -0.143693819604302 0.435620073805006 no 1939 0.44287112589557 2682 5816522
SGTC_2988 9073640 71.4286 µM -0.143840714648761 0.435561728512542 no 1940 0.442813125762731 2820 9102229
SGTC_2381 9035592 200 µM -0.145223867974497 0.435012422327891 no 1941 0.442267060887798 2706 4749657
SGTC_585 0kpi-0023 191 µM -0.14533060532828 0.434970037801791 no 1942 0.442224925838975 2771 64601
SGTC_2787 5284540 71.43 µM -0.145396796725836 0.434943754117076 no 1943 0.442198796816414 2743 736958
SGTC_2753 fluvastatin 17.09 µM -0.146635977356146 0.434451745891212 no 1944 0.441709677397698 2740 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1024 4507-0395 26 µM -0.146697159397431 0.434427456601933 no 1945 0.441685530410252 2836 4201836
SGTC_1307 1187-1599 12.2 µM -0.151818256257871 0.43239526580742 no 1946 0.439665141316782 2672 1538471
SGTC_2796 7949634 45.45 µM -0.152509884483499 0.432120944675576 no 1947 0.439392397471179 2654 2971588
SGTC_863 0466-0191 129 µM -0.154215222336297 0.431444695053595 no 1948 0.438720020040065 2689 765160 YPR165W RHO1
SGTC_223 busulfan 5 mM -0.154344059330607 0.431393613039567 no 1949 0.43866922958941 2782 2478 A DNA alkylator.
SGTC_2276 7947513 42.08 µM -0.154369007353643 0.431383721640061 no 1950 0.438659394632416 2770 2105100
SGTC_2475 5812728 15.03 µM -0.154878710482111 0.431181643822525 no 1951 0.438458468841082 2660 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_235 0330-0087 5 mM -0.155475519346464 0.430945054805525 no 1952 0.438223225990864 2695 46494818 YHR062C RPP1
SGTC_2571 chrysanthemic acid 100 µM -0.15608319667712 0.430704182733915 no 1953 0.437983721568294 2750 2743 An insecticide.
SGTC_1957 st077035 62.4 µM -0.156651128923131 0.43047908818141 no 1954 0.437759902446135 2693 705593
SGTC_2518 prenyletin 46.28 µM -0.156717848177874 0.430452646119587 no 1955 0.437733610043081 2735 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_51 1013-0126 23.419 µM -0.157024669001181 0.430331051427732 no 1956 0.43761270310936 2743 1627850
SGTC_1441 4106-0040 13 µM -0.157098384015916 0.430301838766882 no 1957 0.43758365556898 2670 2904180
SGTC_1783 st039459 87.517 µM -0.158194997724528 0.429867304806495 no 1958 0.437151572680091 2916 729761
SGTC_649 1123-0311 367 µM -0.158698644695779 0.429667762768445 no 1959 0.436953153011161 2769 693629 YIL048W NEO1
SGTC_1723 st034307 2.5525 µM -0.159280389949482 0.429437301003458 no 1960 0.436723985033115 2762 867466
SGTC_1016 4226-1401 38 µM -0.159817245490001 0.429224643892644 no 1961 0.436512519379991 2660 2901613
SGTC_1806 st050005 60.3 µM -0.161824548404854 0.428429701392906 no 1962 0.435722010500463 2693 5194765
SGTC_2041 5107442 45.335 µM -0.161963450504155 0.428374703366747 no 1963 0.435667318032875 2792 793005
SGTC_2594 a-mangostin 100 µM -0.162126695339068 0.428310068658227 no 1964 0.435603042226973 2847 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_52 0329-0193 875 nM -0.162911532655467 0.427999349219991 no 1965 0.435294045196525 2919 3739292
SGTC_224 benfluorex 43.875 µM -0.163057190490909 0.427941687753267 no 1966 0.435236702826456 2718 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.1635899125451 0.427730812555884 no 1967 0.435026993171651 2697 2724 A muscle relaxant with antifungal properties.
SGTC_745 0469-0705 296 µM -0.164522752408904 0.427361602601999 no 1968 0.43465981847711 2830 3486736
SGTC_579 4491-1009 110 µM -0.165483275910545 0.426981502175462 no 1969 0.434281806121418 2707 1271041
SGTC_3320 9137005 35.139 µM -0.166328414775416 0.426647118054369 no 1970 0.433949252865956 2757 4908713
SGTC_2183 6420625 130.508 µM -0.166615575405757 0.426533513262534 no 1971 0.433836268805859 2699 2897619
SGTC_1994 st072947 40.9 µM -0.166654551610321 0.426518094196347 no 1972 0.433820933938238 2801 5286565 YDL195W SEC31
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.166853253668557 0.426439489002165 no 1973 0.433742757793916 2889 94937 An inhibitor of serotonin biosynthesis.
SGTC_1191 1487-1166 10.6 µM -0.166895177660119 0.426422904527016 no 1974 0.433726263801496 2815 3955771
SGTC_153 4077-0274 519.67 µM -0.167764081151972 0.426079209233061 no 1975 0.433384440515359 2857 3121976
SGTC_3318 9139014 38.6185 µM -0.168381598100274 0.425834984147648 no 1976 0.433141541999375 2697 16643984
SGTC_551 k048-0028 34.9 µM -0.1707045579104 0.424916519859658 no 1977 0.432228039371485 2855 6836383
SGTC_2416 tofa 880 nM -0.170751242113384 0.42489806576931 no 1978 0.432209684531477 2740 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1101 ebselen 5.29 µM -0.170899390883513 0.424839504206194 no 1979 0.43215143781077 2776 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_841 0251-0215 91.2 µM -0.171114343228338 0.424754538881735 no 1980 0.432066928970944 2753 3888614
SGTC_1798 st045719 60.953 µM -0.171127729990205 0.424749247542768 no 1981 0.432061666048025 2704 3980186
SGTC_645 0845-0943 5.41 µM -0.171402066777687 0.424640814379105 no 1982 0.431953814887423 2754 1885106
SGTC_835 0312-0010 67.2 µM -0.172073944697197 0.42437527494067 no 1983 0.43168969816552 2704 1626196
SGTC_512 prima-1 270 µM -0.173408787860498 0.423847820474294 no 1984 0.431165059017996 2877 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2878 9043973 25.97 µM -0.17371411946721 0.423727189839196 no 1985 0.431045070255199 2882 6465167
SGTC_431 k089-0097 107 µM -0.174305446597335 0.423493588217637 no 1986 0.430812709502075 2751 5499420
SGTC_173 1273-0061 2.693 µM -0.174611879654593 0.423372543530303 no 1987 0.430692306692047 2834 2847414 YPL266W DIM1
SGTC_2029 5175081 200 µM -0.175197759249754 0.423141134290724 no 1988 0.430462122481346 2708 1380876
SGTC_3219 9131112 49.47 µM -0.175895775738361 0.422865468121868 no 1989 0.430187912041988 2754 17612988 YMR079W SEC14
SGTC_472 calcifediol 10 µM -0.176034850734646 0.422810548036674 no 1990 0.430133281511139 2793 5283731 A vitamin D metabolite.
SGTC_1043 0916-0009 19.3 µM -0.180195810819463 0.421168102304742 no 1991 0.428499423542735 2778 3101130
SGTC_1815 st051655 58.2 µM -0.181971267654268 0.420467696119267 no 1992 0.427802637248207 2768 5984156
SGTC_315 k915-0449 187 µM -0.182630189989575 0.420207819470568 no 1993 0.42754409726739 2761 20970215 YNL149C PGA2
SGTC_1594 piperine 70.1 µM -0.183354409464608 0.419922229986466 no 1994 0.427259972676138 2729 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2697 mebhydrolin 72.4 µM -0.183663193786445 0.419800476458312 no 1995 0.427138842383076 2848 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1958 st076513 41.9 µM -0.184626682725751 0.419420622569663 no 1996 0.426760927966666 2718 732122 YGL099W LSG1
SGTC_376 3970-0862 59.1 µM -0.185175903307949 0.419204126856506 no 1997 0.426545534300251 2844 3135186
SGTC_2698 st077697 67.5 µM -0.186486925825929 0.418687437584397 no 1998 0.426031465350402 2772 3154499
SGTC_942 3253-1115 227 µM -0.189685516228714 0.417427425983307 no 1999 0.424777785563891 2905 46497897
SGTC_39 0986-0283 58.349 µM -0.189715764810928 0.417415514270138 no 2000 0.424765933315175 2870 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_271 rotenone 740 µM -0.190954101973261 0.416927929585751 no 2001 0.424280776352811 2872 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1263 0774-1208 64.8 µM -0.191105687291181 0.416868252922366 no 2002 0.424221395972348 2860 906585
SGTC_2844 9010103 25.97 µM -0.191580387422806 0.416681383633211 no 2003 0.424035453250058 2937 2480525
SGTC_1674 st016616 23.6 µM -0.191770290476753 0.41660663213275 no 2004 0.42396107188453 2693 625830
SGTC_2649 anisomycin 9.56 µM -0.193073476822043 0.41609374064596 no 2005 0.423450712125243 2794 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1932 st074806 40.9 µM -0.195129359032652 0.41528490348483 no 2006 0.42264583956754 2992 17251235
SGTC_1397 3532-0190 20.1 µM -0.195806762508854 0.415018473898687 no 2007 0.422380708409626 2721 5322280
SGTC_312 4092-0653 6.84 µM -0.196072242378262 0.414914068653535 no 2008 0.422276810961594 2854 1148278
SGTC_15 0266-0086 27.098 µM -0.197796204570249 0.414236232723586 no 2009 0.421602257911089 2817 1712902 YIL048W NEO1
SGTC_2667 digitoxin 100 µM -0.197858707513581 0.414211662294149 no 2010 0.421577806027181 2838 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1251 0490-5699 265 µM -0.199146602316142 0.413705454953689 no 2011 0.421074033930488 2871 3883818
SGTC_940 3232-1287 54.8 µM -0.199905513610011 0.413407231778987 no 2012 0.42077723912244 2748 1585493 YIL048W NEO1
SGTC_989 1501-0895 10.3 µM -0.201901917023941 0.412622960383088 no 2013 0.419996701685876 2786 2830112
SGTC_1574 spiramycin 23.7 µM -0.203253543006463 0.412092182493529 no 2014 0.419468432432324 2742 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_564 3555-0129 330 µM -0.203371233505984 0.412045973519823 no 2015 0.419422441153125 2762 563260
SGTC_2102 5377816 72.7585 µM -0.203591084443331 0.411959656427919 no 2016 0.419336530406016 2946 1379702
SGTC_283 0987-0079 11.7 µM -0.204062128971059 0.411774730948326 no 2017 0.419152474151236 2849 411556
SGTC_2627 acetyl isogambogic acid 100 µM -0.204915686975469 0.411439685985663 no 2018 0.418818999424182 2869 6857789 A caspase activator and apoptosis inducer.
SGTC_1207 2099-0101 141 µM -0.207398033304026 0.410465664676005 no 2019 0.417849509203582 2876 5837381
SGTC_830 4076-0286 57.8 µM -0.213103324851962 0.408229127884136 no 2020 0.415623185676502 2796 6866659
SGTC_90 0870-0863 4.608 µM -0.213825786663415 0.407946126460127 no 2021 0.415341457568386 2770 1738164
SGTC_946 3434-1334 87.4 µM -0.214692804690353 0.407606563142763 no 2022 0.415003416401732 2930 4047976
SGTC_633 0437-0093 97.7 µM -0.215342201224201 0.407352275650662 no 2023 0.414750264753589 2781 2831118
SGTC_1540 guanosine 70.6 µM -0.219033226653282 0.405907706678848 no 2024 0.413312082506338 2759 6802 Guanosine is a purine nucleoside
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.219771086072005 0.405619081085881 no 2025 0.413024719539646 2790 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3317 9138495 8.753 µM -0.220005829575165 0.405527268134894 no 2026 0.412933307294759 2803 17020139
SGTC_1742 st038235 28.8875 µM -0.220473956411464 0.405344189745377 no 2027 0.412751026572308 2922 564103 YBR002C RER2
SGTC_417 st075190 100 µM -0.22079495665251 0.405218662642755 no 2028 0.412626045343679 2940 222757
SGTC_394 menadione 8.33 µM -0.22082087072881 0.405208529371721 no 2029 0.412615956101686 2839 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_513 4245-1575 41.7 µM -0.22132486024884 0.405011465247583 no 2030 0.412419747119849 2911 719745
SGTC_2112 5488546 200 µM -0.222316740784597 0.404623702035691 no 2031 0.412033660454298 2795 600757
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.222995181057027 0.4043585282622 no 2032 0.41176962852064 2802 688664
SGTC_1440 4100-1550 40 µM -0.223706514536424 0.404080545096323 no 2033 0.41149283827187 2804 742806
SGTC_591 4299-0174 154 µM -0.223993655863719 0.403968346383072 no 2034 0.411381119856463 2839 5509088
SGTC_1323 1348-1351 11.2 µM -0.224076599382921 0.403935938181656 no 2035 0.411348850260614 2820 6989654
SGTC_3218 9131285 49.47 µM -0.224891369791898 0.4036176211679 no 2036 0.411031891625223 2945 17156417
SGTC_993 3909-8757 62.7 µM -0.225169808142553 0.403508854638945 no 2037 0.410923587986336 2853 4288324 YLR208W SEC13
SGTC_2909 7941780 10.49 µM -0.225715923673561 0.403295546902715 no 2038 0.410711186187013 2875 1243215
SGTC_443 clozapine 122 µM -0.226091409928193 0.403148902089021 no 2039 0.410565162756338 2778 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_407 eburnamonine 100 µM -0.227798760015087 0.40248227467654 no 2040 0.409901345359732 2782 3195
SGTC_2596 sinensetin 100 µM -0.228319807450117 0.402278890338572 no 2041 0.409698813537433 2866 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2453 5731132 22.18 µM -0.228554650868002 0.402187230797533 no 2042 0.409607537466001 2953 1362040
SGTC_1117 retinoic acid 1.10837 µM -0.228960346058478 0.402028900370543 no 2043 0.409449868358765 2966 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1217 1183-1422 255 µM -0.230236187855801 0.401531083217813 no 2044 0.408954121617824 2946 2849664
SGTC_2290 7904846 200 µM -0.231793526064304 0.400923646364034 no 2045 0.408349192793502 2895 2962154
SGTC_812 4251-0442 148 µM -0.232119096734521 0.400796688347029 no 2046 0.408222756427214 2840 5723007
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.232435660686224 0.400673252594401 no 2047 0.408099827009274 2990 688751
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.233401414121302 0.400296743876338 no 2048 0.407724857593034 2986 23847180
SGTC_2985 9022375 71.43 µM -0.234462546389113 0.399883157582949 no 2049 0.407312953255909 3017 4939335
SGTC_2473 5854593 8.94 µM -0.235482357145945 0.399485782540504 no 2050 0.406917185424162 2773 2872951
SGTC_2288 7946289 167.31 µM -0.2357379178518 0.399386218159673 no 2051 0.406818022383242 3006 1246052
SGTC_898 1000-0849 28.3 µM -0.237847424127636 0.398564622104683 no 2052 0.405999717394609 2831 6751807
SGTC_542 3381-0244 89.3 µM -0.238367011173834 0.398362325732634 no 2053 0.405798225675001 3013 1112843
SGTC_2188 6126565 140.678 µM -0.239329959797503 0.397987482914111 no 2054 0.405424867881815 2929 874518
SGTC_844 0330-0132 15.3 µM -0.239580141406842 0.397890111200668 no 2055 0.405327880663953 2954 2828079
SGTC_2275 7947463 200 µM -0.240199307914529 0.397649156403792 no 2056 0.405087875091194 2827 1225414
SGTC_979 1426-2828 121 µM -0.242435633414186 0.396779193925515 no 2057 0.404221313137221 2968 747872
SGTC_2455 5377712 9.75 µM -0.242856067658306 0.396615696229053 no 2058 0.404058449861885 2916 2243908
SGTC_2809 7964133 12.99 µM -0.242914242844639 0.396593074600283 no 2059 0.404035915895691 2871 1253665
SGTC_2937 9044753 11.33 µM -0.242962410390966 0.396574344741427 no 2060 0.404017258596763 2806 6465530 YGL099W LSG1
SGTC_2495 cafestol 54.53 µM -0.246066355134149 0.395367886753768 no 2061 0.402815433580908 3057 16667697 An anti-infammatory.
SGTC_3345 9148410 3.559 µM -0.246544680874982 0.395182057352552 no 2062 0.402630310626948 2980 4903596
SGTC_3330 9141424 71.43 µM -0.246872644728248 0.395054657269512 no 2063 0.402503393760237 2984 27261020
SGTC_870 0573-2213 57.6 µM -0.249562220851099 0.394010295136563 no 2064 0.401462958814234 2828 3916321
SGTC_2156 5649887 115 µM -0.251212062794521 0.393370038112631 no 2065 0.400825079393011 2956 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3313 9133968 57.047 µM -0.253141324166655 0.392621712009956 no 2066 0.400079503240092 2810 1494643
SGTC_1401 3807-4679 7.6 µM -0.255796785116003 0.391592355445787 no 2067 0.399053878225261 2841 3291456
SGTC_1449 4112-4002 201 µM -0.257821557702559 0.390807986715439 no 2068 0.398272313082632 2895 2059539
SGTC_3177 9107506 49.47 µM -0.258086640283505 0.390705330216307 no 2069 0.398170020955729 2980 8897194
SGTC_2856 9022925 19.48 µM -0.258559376277468 0.390522276280323 no 2070 0.397987615288012 3023 4944862
SGTC_157 1348-1695 65.819 µM -0.258795681794579 0.390430782598996 no 2071 0.397896444917055 2857 5380510
SGTC_1704 st028805 70.8 µM -0.259255672418056 0.390252699060649 no 2072 0.397718989321204 2910 2876101
SGTC_746 1095-0025 46.6 µM -0.259939870699869 0.389987857026872 no 2073 0.397455077850567 3037 6749286
SGTC_1444 4112-3581 28 µM -0.260387072155111 0.38981478019831 no 2074 0.397282607020855 2876 2877249
SGTC_504 lovastatin 124 µM -0.260809929717973 0.389651145086765 no 2075 0.397119543298025 2899 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1150 3909-7983 10.9 µM -0.260870186139147 0.389627828977337 no 2076 0.397096308482082 2894 23965914
SGTC_1967 st070177 51.4 µM -0.261209395901063 0.389496579809571 no 2077 0.396965516353416 3037 5729214
SGTC_2393 9031399 185.94 µM -0.261319118057591 0.389454128121836 no 2078 0.396923212284172 3034 1526623 YDL150W RPC53
SGTC_185 k048-0037 25.491 µM -0.262175917729231 0.389122676287882 no 2079 0.396592909522774 3015 6827589
SGTC_1513 0337-0559 19 µM -0.262888993359335 0.388846885405494 no 2080 0.396318070023075 2893 775073
SGTC_516 3992-2719 87.3 µM -0.262925323579358 0.388832835738594 no 2081 0.396304068707677 2804 5350887 YDR037W KRS1
SGTC_3 0833-0587 95.581 µM -0.263710148364789 0.388529362866715 no 2082 0.396001637506503 2932 5382644
SGTC_1527 coumarin 137 µM -0.266777248833198 0.387344042867786 no 2083 0.39482033619752 3066 323 A hepatotoxic, DNA x-linker.
SGTC_2413 inermin 26.06 µM -0.268036764687562 0.386857590281849 no 2084 0.394335509823405 3174 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_200 k038-0079 37.545 µM -0.269321074756506 0.386361744589668 no 2085 0.393841307910681 2894 3436683
SGTC_2682 pyrogallin 40.03 µM -0.269972289493659 0.386110394807933 no 2086 0.393590786038949 2915 822798 An ATP competetive kinase inhibitor.
SGTC_3001 9076041 71.4286 µM -0.270441065462448 0.38592949061691 no 2087 0.39341047549476 2877 16004211
SGTC_3203 9113543 49.47 µM -0.270796741411138 0.38579224912527 no 2088 0.3932736831251 3033 17018012
SGTC_430 0958-0115 16.4 µM -0.271865006825915 0.38538013312657 no 2089 0.39286290932204 2913 6833180
SGTC_951 1171-0579 82.7 µM -0.272448234059531 0.38515518998976 no 2090 0.392638694702269 2833 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1899 st063254 59.6 µM -0.272524855777218 0.385125640862551 no 2091 0.3926092410604 2848 3093813
SGTC_601 0986-0029 62.9 µM -0.27414973993071 0.38449916241457 no 2092 0.391984775283121 2907 24747981
SGTC_278 4092-0821 23.9 µM -0.274270961547163 0.384452437161814 no 2093 0.391938199244356 2956 877900
SGTC_1366 1683-0113 21.9 µM -0.27518373280039 0.384100660571022 no 2094 0.391587542018378 2889 708623
SGTC_1273 0849-0096 14.1 µM -0.276686907466504 0.383521554191641 no 2095 0.391010262938223 2922 5286025
SGTC_2116 5511452 16.8835 µM -0.276922034275596 0.383430993776403 no 2096 0.390919986536988 3017 870744
SGTC_732 3970-1727 52.7 µM -0.277269678970848 0.383297108133418 no 2097 0.390786519921833 3003 1275699
SGTC_190 3970-0790 3.722 µM -0.277309979408702 0.383281588446717 no 2098 0.390771048741254 2974 2832352
SGTC_254 nsc-64875 3.808 µM -0.280896748096957 0.381901077817972 no 2099 0.389394797461379 3052 56993
SGTC_528 3492-0019 172 µM -0.282151727972533 0.381418402317362 no 2100 0.388913585291672 2977 2869262
SGTC_2490 carminic acid 95.39 µM -0.282360823821817 0.381338000245801 no 2101 0.388833425669947 2862 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1162 k048-0130 20.1 µM -0.28306633274745 0.381066753955323 no 2102 0.388562994560642 2910 6797406
SGTC_1560 lithocholic acid 53.1 µM -0.283257434617254 0.380993291267166 no 2103 0.388489751919925 2942 9903 A bile acid which acts as a detergent.
SGTC_2202 7226349 200 µM -0.286986322386755 0.379560707191343 no 2104 0.387061396543777 2896 844334
SGTC_1330 1469-0054 61.8 µM -0.28733872643588 0.379425403841594 no 2105 0.386926486435981 3058 7102664
SGTC_822 1487-0950 154 µM -0.289149381170029 0.378730447350319 no 2106 0.386233532993276 3070 1958375
SGTC_32 0928-0142 34.1 µM -0.289488373003035 0.378600380682176 no 2107 0.386103838092923 2991 2244242
SGTC_236 1509-0011 5.31 µM -0.290345633963222 0.378271522411853 no 2108 0.385775915402445 3020 3107280
SGTC_901 1112-0062 60.1 µM -0.291828553181564 0.377702860444015 no 2109 0.385208856374644 2930 1908457
SGTC_468 gf-109203x 121 µM -0.292374864505655 0.377493430606878 no 2110 0.385000012125414 2986 2396 A protein kinase C inhibitor.
SGTC_1749 st037932 54.2 µM -0.293314567532349 0.377133277346166 no 2111 0.384640859903315 3053 594497
SGTC_986 1493-0483 84 µM -0.297390203218674 0.375572478055285 no 2112 0.383084311122539 3039 40079
SGTC_1973 st070275 50.2 µM -0.298473726347826 0.375157874905531 no 2113 0.382670813046389 2944 17118334
SGTC_718 1130-0073 349 µM -0.298477159239869 0.375156561560391 no 2114 0.382669503185764 3101 6740020
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.299702297490408 0.374687944522732 no 2115 0.382202122989488 3350 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1124 fisetin 1.16336 µM -0.30012662140786 0.374525683147417 no 2116 0.382040286866248 2990 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_368 fentichlor 4.58 µM -0.301550249736632 0.373981450441782 no 2117 0.381497469152929 3013 7329 A pesticide.
SGTC_2948 9070189 9.45 µM -0.30308517152828 0.373394953168747 no 2118 0.380912477202506 3078 6473636 YDL196W YDL196W
SGTC_1364 1653-0028 37.6 µM -0.303104831457205 0.373387442961766 no 2119 0.380904986139758 2995 5718652
SGTC_3128 9127691 49.47 µM -0.30335900089857 0.373290353090726 no 2120 0.380808143460024 3071 41316314
SGTC_2958 9077254 16.72 µM -0.309491919605174 0.370950099191442 no 2121 0.37847367894075 3151 16457351
SGTC_269 exalamide 29 µM -0.309594742634039 0.370910903440207 no 2122 0.378434577384281 2961 3316 A derivative of salicylamide.
SGTC_1336 1486-0901 104 µM -0.310839571232875 0.370436485839794 no 2123 0.377961292644596 3011 5006114
SGTC_1647 st011722 22.4 µM -0.311067915178188 0.370349482860411 no 2124 0.377874495964433 3110 2854783
SGTC_1037 k284-1091 78.7 µM -0.311271931686398 0.370271754663521 no 2125 0.377796951692984 2920 3334711
SGTC_124 0136-0217 7.121 µM -0.312229475305028 0.369907011188703 no 2126 0.377433066484547 3107 3976905
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.312501643105886 0.369803359517121 no 2127 0.377329657263788 3024 77254
SGTC_327 1273-0057 3.96 µM -0.312906604906382 0.369649152435615 no 2128 0.377175809699649 2999 3108138
SGTC_1835 st008666 49.2 µM -0.313200571286756 0.369537224890287 no 2129 0.377064142211759 2944 690455
SGTC_2720 fluspirilene 36.88 µM -0.31362558297561 0.369375421460373 no 2130 0.3769027133997 3037 3396 An atypical antipsychotic.
SGTC_1960 st011366 51.8 µM -0.313901491756684 0.369270394409111 no 2131 0.376797928676216 2937 3972846
SGTC_2361 9034121 116 µM -0.315158060733849 0.368792194130603 no 2132 0.376320823401051 2985 6496917
SGTC_2238 6671620 73.2395 µM -0.316789734266594 0.368171547074706 no 2133 0.375701577103584 2889 729941
SGTC_3071 9117417 49.47 µM -0.318104782956392 0.367671586230516 no 2134 0.375202727830892 3014 45595590 YGL055W OLE1
SGTC_291 SEC14.278 35.5 µM -0.319711949999978 0.367060871018783 no 2135 0.374593350050267 3090 1068044
SGTC_1487 3970-0795 2.82 µM -0.320408786942769 0.366796180969524 no 2136 0.374329232684721 3062 3765103
SGTC_668 1682-0499 62.6 µM -0.321824248714283 0.366258719914181 no 2137 0.373792921489848 3010 682214
SGTC_2977 9011197 71.43 µM -0.322162674423738 0.366130256036036 no 2138 0.37366472987106 3176 2704722
SGTC_846 0335-0850 148 µM -0.322816894927721 0.365881961354252 no 2139 0.373416958587509 3058 6819598
SGTC_1499 4480-0877 67.3 µM -0.322999610565568 0.365812625771629 no 2140 0.37334776849722 2973 2861909
SGTC_299 1273-0059 1.44 µM -0.32339809628587 0.365661426555177 no 2141 0.373196885546503 3071 2848077
SGTC_673 1082-0474 110 µM -0.323605488731254 0.365582742968859 no 2142 0.373118365997151 3009 3098046
SGTC_184 1494-0393 24.714 µM -0.32364271805534 0.365568618960766 no 2143 0.3731042713947 2934 3090647
SGTC_548 1436-0017 110 µM -0.323759578056727 0.365524285963491 no 2144 0.37306003061866 3122 9677137
SGTC_220 paclitaxel 373.376 µM -0.324424479349901 0.365272077596256 no 2145 0.372808344631679 3073 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2160 5660466 132.927 µM -0.324555348922872 0.365222443400021 no 2146 0.372758812785739 3044 2859134
SGTC_3216 9129716 49.47 µM -0.325372125874812 0.364912719859411 no 2147 0.372449724554056 2985 8056934
SGTC_1630 st005209 31.3 µM -0.325642485156242 0.364810218453394 no 2148 0.372347432120442 3034 3367314
SGTC_1939 st074455 53.6 µM -0.330082559396448 0.363128238824731 no 2149 0.370668790488439 3205 1644229
SGTC_74 000s-0487 160.283 µM -0.330400467302975 0.363007910373993 no 2150 0.370548694242213 2985 677548
SGTC_1461 k072-0203 53.8 µM -0.330874043696537 0.362828686328559 no 2151 0.370369814419519 3036 5418714
SGTC_2035 5154463 94.595 µM -0.332830802123344 0.362088473904254 no 2152 0.36963100290862 3145 2769623
SGTC_266 formosanin C 406 nM -0.332833011679146 0.36208763835323 no 2153 0.369630168920041 3094 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_212 3807-4682 38.772 µM -0.332921508196881 0.362054173635098 no 2154 0.36959676674446 3063 3125501 YBL034C STU1
SGTC_194 1486-1323 56.904 µM -0.333331757115829 0.361899052897891 no 2155 0.369441935019969 3040 5178754
SGTC_1073 triclabendazole 3.09 µM -0.335906739887584 0.360925935603349 no 2156 0.368470597194082 3072 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_378 3970-0959 8.33 µM -0.336116536542165 0.360846690445608 no 2157 0.368391494391521 3123 6615653
SGTC_1696 st025591 34.7925 µM -0.336698261465362 0.360626990441115 no 2158 0.368172187039308 2999 2787147
SGTC_3010 9080089 71.4286 µM -0.338649534967287 0.359890389401219 no 2159 0.36743688083881 3100 17027233
SGTC_2506 ethyl hematommate 54.16 µM -0.338827238155689 0.359823332672723 no 2160 0.367369940330051 3069 3940691 An allergen.
SGTC_1969 st069479 40.1 µM -0.340151376479958 0.359323801849694 no 2161 0.366871266560842 3175 3895485
SGTC_3032 9089427 49.47 µM -0.340363696475597 0.359243726526632 no 2162 0.366791327195057 3104 17173707
SGTC_3269 9137823 49.47 µM -0.341644034956275 0.358760985044151 no 2163 0.366309396967144 2977 17682936
SGTC_1260 0700-1617 7.75 µM -0.342074260535194 0.358598822483399 no 2164 0.36614750369652 3123 2853078
SGTC_280 3448-3607 3.04 µM -0.346224830499136 0.357035684066164 no 2165 0.364586877662389 3109 626179
SGTC_1246 0422-0085 105 µM -0.346485585053003 0.356937561529398 no 2166 0.364488907785028 3164 264295
SGTC_2385 9074692 200 µM -0.347479458174172 0.356563651618583 no 2167 0.36411557412554 3043 17046906
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.349507209108707 0.355801209174282 no 2168 0.363354279789596 3105 17037758
SGTC_1220 1838-0075 193 µM -0.349890355308933 0.35565720933355 no 2169 0.363210492725669 3043 5529645
SGTC_3094 9117742 49.47 µM -0.350350921258427 0.355484139685372 no 2170 0.363037677098618 2963 17149698
SGTC_166 k072-0058 166.424 µM -0.351135574565635 0.35518935440898 no 2171 0.362743320190376 3146 5846229
SGTC_1902 st060212 70.5 µM -0.354576377506278 0.353897709134055 no 2172 0.361453487874629 3094 688944
SGTC_731 3966-0296 387 µM -0.355132233176977 0.353689203319624 no 2173 0.361245264932675 3020 660956
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.356381802234745 0.35322064047715 no 2174 0.360777327826105 3050 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_570 0987-0065 62.6 µM -0.357554004189734 0.352781290882433 no 2175 0.36033855243406 2990 3104428
SGTC_148 3253-0744 288.01 µM -0.357881922008616 0.352658420067205 no 2176 0.360215840032707 3051 6893655
SGTC_2928 9011484 9.79 µM -0.35801086275864 0.352610110174025 no 2177 0.360167592164094 3151 2994751
SGTC_1941 st076221 61.8 µM -0.360043278413122 0.351848944799374 no 2178 0.359407384650425 3153 2828568
SGTC_1408 3909-7976 48.8 µM -0.360549898703983 0.351659301365385 no 2179 0.35921797418566 3079 24152374
SGTC_2157 5649910 96.377 µM -0.360635488905741 0.351627265984419 no 2180 0.359185977934898 3028 2858091
SGTC_3186 9110464 49.47 µM -0.363943357771987 0.350389979738845 no 2181 0.357950153393003 3160 17018021
SGTC_656 4090-1979 187 µM -0.364624847353887 0.35013526970236 no 2182 0.357695732244141 3177 22330961
SGTC_546 peri-Naphthalide 147 µM -0.365660639562113 0.349748266444045 no 2183 0.357309160046942 3072 223824 A penicillin ester.
SGTC_1605 st000082 49.1 µM -0.366449726993172 0.349453544253487 no 2184 0.357014759756642 3163 1114022
SGTC_825 1988-2224 89.6 µM -0.367710929972776 0.348982676543015 no 2185 0.356544394885146 3046 1180859
SGTC_3144 9087057 49.47 µM -0.367964282793415 0.348888115767777 no 2186 0.356449933391447 3193 17249618
SGTC_1529 apigenin 74 µM -0.368242947711416 0.348784118406263 no 2187 0.356346044562238 3288 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2666 tannic acid 100 µM -0.369329248771687 0.348378820878123 no 2188 0.355941163434339 3128 16134267 A thiamine antagonist.
SGTC_801 0866-0028 10.1 µM -0.370349503739433 0.347998322638761 no 2189 0.35556104658996 3015 6849771
SGTC_753 1322-0200 289 µM -0.370762567763329 0.347844316267908 no 2190 0.355407191963073 3187 5403907
SGTC_2125 5246583 200 µM -0.371646356989547 0.347514889521156 no 2191 0.35507808471994 3228 835267
SGTC_1350 1495-0454 146 µM -0.372331485328908 0.34725959154443 no 2192 0.354823029582088 3209 1069057
SGTC_1365 1672-3266 55.4 µM -0.372462477886127 0.347210787941696 no 2193 0.354774271926799 3151 6415873
SGTC_2058 5236698 133 µM -0.37391433120978 0.346670044026817 no 2194 0.354234026909674 3082 766665
SGTC_1810 st050138 53 µM -0.37459535740917 0.346416502793975 no 2195 0.353980713148455 3193 3444541
SGTC_756 0508-1999 28.3 µM -0.374677942748799 0.346385761531821 no 2196 0.353949999186586 3051 6753853
SGTC_1074 carmofur 3.8 µM -0.374694060835347 0.346379761912753 no 2197 0.353944004888513 3063 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3044 9093193 49.47 µM -0.375206620081561 0.346188992611396 no 2198 0.353753403574519 3156 25236277
SGTC_789 1309-1135 70.6 µM -0.375380186096854 0.346124401960112 no 2199 0.353688869271309 3049 3092424
SGTC_1254 0550-0035 264 µM -0.375656262216877 0.346021672542813 no 2200 0.353586228922302 3190 15121435
SGTC_1854 st056233 32.9 µM -0.37638316084153 0.345751243846201 no 2201 0.353316031452698 3165 5393174
SGTC_3323 9138564 53.9225 µM -0.378904244387133 0.344813933472151 no 2202 0.352379486123789 3234 43912313 YNL103W MET4
SGTC_2274 7947094 46.08 µM -0.379910546078491 0.344440067288647 no 2203 0.352005909310086 3063 2971028
SGTC_3180 9109287 49.47 µM -0.380321048420191 0.34428759903674 no 2204 0.351853556479537 3190 18891271
SGTC_3339 9145883 14.936 µM -0.381848569938183 0.34372047139222 no 2205 0.351286844985252 3195 2030670
SGTC_2739 tacrine 100.86 µM -0.382594073999209 0.343443813354271 no 2206 0.35101038241027 3179 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_314 1671-0008 2.74 µM -0.382682320415446 0.343411070481743 no 2207 0.350977662343338 3097 3913060
SGTC_1603 st002045 67.8 µM -0.383193267577315 0.343221512203877 no 2208 0.350788234729997 3209 5887985
SGTC_2641 levomentholum 100 µM -0.384825019048067 0.342616406664542 no 2209 0.350183530719184 3134 16666
SGTC_1394 3474-0001 65.7 µM -0.385680789846862 0.342299220783042 no 2210 0.349866545824314 3118 5017666 YIL048W NEO1
SGTC_1077 5-fluorocytosine 377 nM -0.385819568362929 0.342247793902666 no 2211 0.349815150915437 3134 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_936 3005-4620 401 µM -0.386127656188827 0.34213363686315 no 2212 0.349701064232044 3270 777207
SGTC_1279 0874-0590 65.2 µM -0.388583070042727 0.341224338779521 no 2213 0.348792296295223 3137 3523074
SGTC_10 0279-0212 42.575 µM -0.388671156904538 0.341191735207244 no 2214 0.348759710732027 3104 39851 YBR002C RER2
SGTC_908 3448-7491 47.7 µM -0.388709003763556 0.3411777273211 no 2215 0.348745710562075 3064 1203031
SGTC_948 3448-0295 75.3 µM -0.388847695041907 0.341126396751411 no 2216 0.348694408158337 3099 678569
SGTC_517 1365-0151 113 µM -0.389415212907253 0.340916385231941 no 2217 0.348484510086471 3248 768657
SGTC_2808 7946468 45.46 µM -0.390993083731481 0.34033274905092 no 2218 0.347901174070068 3141 2970879
SGTC_1339 1486-1321 22.7 µM -0.39129486846066 0.340221165871102 no 2219 0.347789645743957 3111 3469382
SGTC_2489 cantharidin 73.42 µM -0.39133317462106 0.340207003387509 no 2220 0.347775490164359 3095 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_198 3454-2873 16.191 µM -0.391912004032373 0.339993027084094 no 2221 0.347561616575013 3113 710957
SGTC_2834 9001755 58.44 µM -0.392066465879761 0.339935935764727 no 2222 0.347504552154781 3103 2989575
SGTC_640 3381-0960 37.1 µM -0.39251529939419 0.33977006127936 no 2223 0.347338754612622 3169 1745025
SGTC_2888 9058547 12.99 µM -0.392622863815608 0.339730313522831 no 2224 0.347299025026141 3084 16476514
SGTC_1660 st012960 28.1 µM -0.393280692035239 0.339487268256205 no 2225 0.347056088613065 3177 24207266
SGTC_2439 5492030 7.2 µM -0.394820592467454 0.338918588290449 no 2226 0.346487648214479 3183 5722370
SGTC_1080 nisoldipine 24.4 µM -0.39517979812579 0.338785987596058 no 2227 0.346355100329789 3023 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1062 mesoridazine 14.2 µM -0.395746824349127 0.338576710644676 no 2228 0.346145904375685 3108 4078 A neuroleptic.
SGTC_1980 st071811 45.7 µM -0.396626894246033 0.33825199485317 no 2229 0.345821308561899 3248 4974850
SGTC_1402 3909-7673 35.9 µM -0.396890724132532 0.338154674038974 no 2230 0.345724022355633 3084 5328014
SGTC_311 1315-0136 58 µM -0.397348467628777 0.337985848586223 no 2231 0.345555255459818 3281 6759207
SGTC_819 1013-0258 27.7 µM -0.398303238714702 0.337633813765163 no 2232 0.345203336704133 3119 5753198
SGTC_1139 k015-0024 46.9 µM -0.398541747910726 0.337545894905218 no 2233 0.345115445556461 3227 2766652
SGTC_2634 4'-methoxyflavone 100 µM -0.398781629491674 0.337457479102264 no 2234 0.345027057108439 3162 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1017 4239-0030 168 µM -0.399667384303616 0.337131084442063 no 2235 0.344700758965534 3126 1149593
SGTC_2111 5486399 200 µM -0.401054612977985 0.336620146413242 no 2236 0.344189957899399 3125 689674
SGTC_2765 myclobutanil 7.74 µM -0.401310109559707 0.336526075871154 no 2237 0.344095910693015 3216 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2564 betulinic acid 100 µM -0.401394190749276 0.336495120499977 no 2238 0.344064962872817 3359 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_794 k038-0031 316 µM -0.403005683584868 0.335902046880203 no 2239 0.343472021673078 3214 6624242
SGTC_210 3551-0445 56.827 µM -0.403423214703587 0.335748450515022 no 2240 0.343318455803604 3234 2865180 YOR207C RET1
SGTC_1976 st070609 63.5 µM -0.404481708402254 0.335359187468736 no 2241 0.342929263035145 3075 682556
SGTC_2307 7538926 6.34 µM -0.405463008506077 0.334998470326124 no 2242 0.34256860203596 3132 96582
SGTC_2059 5238311 157 µM -0.405902078338563 0.334837121430317 no 2243 0.342407275454098 3060 703021
SGTC_814 3342-0569 96 µM -0.406365452598097 0.334666874233005 no 2244 0.342237049924065 3208 4346283
SGTC_623 k072-0108 16.9 µM -0.407894047403074 0.334105498096583 no 2245 0.341675731562961 3184 5382803
SGTC_449 xestospongin c 11.1929 µM -0.407927601043685 0.33409317968491 no 2246 0.341663414183653 3211 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_364 0083-0097 67.7 µM -0.408403922359476 0.3339183290589 no 2247 0.341488577120226 3245 5207356
SGTC_234 nsc-17383 10.7 µM -0.409111287569461 0.333658732109639 no 2248 0.341228996545306 3265 408974
SGTC_115 0527-0192 112.043 µM -0.410187053715146 0.333264087822102 no 2249 0.340834368530887 3222 4233931
SGTC_889 0919-1524 82.7 µM -0.410959460592753 0.332980844511534 no 2250 0.340551130483448 3194 3905452
SGTC_1813 st051246 8.6015 µM -0.411278253796109 0.332863970102347 no 2251 0.340434256681933 3195 5291959
SGTC_1511 0906-3109 28.5 µM -0.41175318930575 0.33268988167871 no 2252 0.340260167468258 3139 2882180
SGTC_1642 st009582 77.7 µM -0.413175005030988 0.332168928444539 no 2253 0.339739199741677 3278 6739311
SGTC_1399 3562-5772 25 µM -0.414816057549261 0.331568049871534 no 2254 0.339138281842454 3097 23847490
SGTC_3311 9131146 2.8755 µM -0.416603910517596 0.33091391270618 no 2255 0.338484074275941 3160 4900406 YPR165W RHO1
SGTC_2912 7964298 10.93 µM -0.416889367651483 0.330809517755125 no 2256 0.338379665424349 3221 2975850
SGTC_1523 st012844 44.7 µM -0.417159105972566 0.330710883444188 no 2257 0.338281017305326 3269 4274103
SGTC_3185 9108267 49.47 µM -0.418483019545084 0.330226942916008 no 2258 0.337796999524598 3227 4910486
SGTC_1289 0976-0073 69.1 µM -0.420109765303787 0.329632694483872 no 2259 0.337202634604269 3242 3391136
SGTC_1156 4092-0367 4.88 µM -0.420373235947418 0.329536489359913 no 2260 0.337106408376602 3183 1357585
SGTC_1707 st032323 6.317 µM -0.420490836927224 0.329493551530498 no 2261 0.337063460926193 3174 3132057 YMR211W DML1
SGTC_1475 4092-1048 11.7 µM -0.420599484095982 0.329453884865534 no 2262 0.337023785262348 3227 2881759
SGTC_3052 9092717 49.47 µM -0.422194252047468 0.328871862218176 no 2263 0.336441618325831 3279 25237534
SGTC_284 0988-0104 32.6 µM -0.422556336009885 0.328739774653119 no 2264 0.336309494818977 3207 4666532
SGTC_2493 resveratrol 26.09 µM -0.423160660495274 0.328519365840845 no 2265 0.33608902339706 3100 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_93 0109-0045 59.227 µM -0.424209845517439 0.328136849518942 no 2266 0.335706390588561 3239 88733
SGTC_2840 9008771 71.43 µM -0.425896646120167 0.327522246379904 no 2267 0.335091579456708 3206 2992978
SGTC_288 1315-0019 35.1 µM -0.426254773314449 0.327391819114764 no 2268 0.334961104745804 3264 6811474
SGTC_3136 9095672 49.47 µM -0.427704968387607 0.326863884353951 no 2269 0.334432966092775 3177 17217380
SGTC_2088 5278280 127.392 µM -0.427791511486215 0.326832389803654 no 2270 0.334401458778194 3254 791502
SGTC_482 fipronil 114 µM -0.427793844585739 0.326831540764925 no 2271 0.334400609394424 3219 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_973 1325-0077 65.9 µM -0.427862015771735 0.326806732970412 no 2272 0.33437579149657 3181 2835149
SGTC_3087 9117406 49.47 µM -0.430496479148764 0.325848627506675 no 2273 0.333417263658046 3255 42546093
SGTC_1381 2324-0066 62.1 µM -0.431113917440732 0.325624242614104 no 2274 0.333192770770383 3250 10885928
SGTC_189 3970-0742 2.116 µM -0.43166246557315 0.325424946264034 no 2275 0.332993375607399 3310 2891807
SGTC_1141 3253-0389 52.6 µM -0.432904948906388 0.324973716721237 no 2276 0.332541912275001 3247 5402031
SGTC_2730 imipramine 71.33 µM -0.433038774513576 0.32492513091008 no 2277 0.332493300457339 3245 3696 A tricyclic antidepressant.
SGTC_1793 st048256 72.231 µM -0.433446746716737 0.324777033685396 no 2278 0.332345122960383 3204 672022
SGTC_1410 3909-8106 77.9 µM -0.433612400345678 0.324716907975835 no 2279 0.332284964231163 3257 1039210
SGTC_1911 st060208 74.3 µM -0.433699872011776 0.324685161066152 no 2280 0.332253199786585 3247 688783
SGTC_2484 5809818 12.04 µM -0.433802572051988 0.324647888805729 no 2281 0.332215906851022 3184 2870548
SGTC_1952 st077036 64.1 µM -0.434570464475266 0.324369258252147 no 2282 0.331937118713395 3227 2937007
SGTC_1417 3966-0327 90.4 µM -0.4348538694931 0.324266449278193 no 2283 0.331834250245343 3226 651118
SGTC_128 0906-2981 13.371 µM -0.435097299912696 0.324178152321225 no 2284 0.331745901611495 3315 6740226
SGTC_1846 st056244 14.8 µM -0.435700837679559 0.323959280068625 no 2285 0.331526898946593 3211 5393182
SGTC_2283 7944793 200 µM -0.437097509919823 0.323453011972052 no 2286 0.331020316546147 3223 2970533
SGTC_26 0302-0163 425.158 µM -0.438107772081942 0.32308701398523 no 2287 0.330654080324585 3221 3100915
SGTC_3204 9114183 49.47 µM -0.439233713633624 0.322679309384533 no 2288 0.330246099443488 3107 17027248
SGTC_607 4491-0986 66.8 µM -0.439639771195648 0.3225323277748 no 2289 0.330099015412343 3299 698981 YDR232W HEM1
SGTC_864 0469-0573 172 µM -0.441340283144633 0.321917090931573 no 2290 0.329483333614062 3194 689425
SGTC_1751 st044839 27.194 µM -0.441353012307532 0.321912487420648 no 2291 0.329478726674867 3270 5291326
SGTC_1888 azatryptophan 97.5 µM -0.442338045670402 0.321556332334016 no 2292 0.329122301899056 3251 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1134 3477-0009 42.5 µM -0.442612627420304 0.321457081973743 no 2293 0.329022974815066 3378 3973534
SGTC_1681 tripelennamine 100 µM -0.444114726376033 0.320914358787408 no 2294 0.328479819978737 3267 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1547 harmine 94.2 µM -0.445428672015601 0.320439930763284 no 2295 0.328004997832528 3227 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_918 glabranin 770.725 nM -0.445800243752092 0.320305820044769 no 2296 0.327870772860927 3223 124049 Also referred to as licorice root.
SGTC_2052 5265182 7.135 µM -0.446122637181094 0.320189478176624 no 2297 0.327754330861615 3301 1239884
SGTC_1711 st032263 62.8 µM -0.447785793461793 0.319589577248227 no 2298 0.327153898625602 3227 3958979
SGTC_492 tmb-8 126 µM -0.450057378595317 0.318770978238835 no 2299 0.326334534024316 3217 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2010 4012422 159 µM -0.450214817143336 0.318714275642841 no 2300 0.326277776659553 3213 952393
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.450862735714492 0.318480967915929 no 2301 0.326044241209725 3209 688761
SGTC_1750 st081859 2.357 µM -0.452439374557419 0.317913539878919 no 2302 0.325476243383289 3282 5291695
SGTC_2232 chlorophetanol 41.5365 µM -0.455659636721595 0.316755904847116 no 2303 0.32431737566825 3308 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1360 1598-0022 39.8 µM -0.457728753408777 0.316013033857389 no 2304 0.32357366385967 3296 761525
SGTC_1122 capsaicin 818.572 nM -0.45817996068262 0.315851136258354 no 2305 0.323411577839229 3317 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2539 epi(13)torulosol 80 µM -0.461456940902913 0.314676384929505 no 2306 0.322235403667299 3301 6708597
SGTC_1351 1496-0003 46.5 µM -0.461680853431187 0.314596183680565 no 2307 0.322155101708149 3335 3891978
SGTC_1761 st044296 37 µM -0.461890551397341 0.314521081751603 no 2308 0.322079905057787 3178 1826700
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.465089498522763 0.313376353171089 no 2309 0.320933683005131 3335 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3266 9136860 49.47 µM -0.466209455374547 0.312976005507453 no 2310 0.320532790972186 3294 4871271 YPR165W RHO1
SGTC_1489 4065-0444 182 µM -0.468215825162455 0.312259345807656 no 2311 0.319815128185334 3324 2877968
SGTC_2196 6573537 42.6665 µM -0.468343792594201 0.312213660884735 no 2312 0.319769378072016 3352 2903087
SGTC_2201 6605497 169.863 µM -0.469998995906115 0.31162300659468 no 2313 0.319177867470405 3261 670741
SGTC_3155 9099265 49.47 µM -0.470193887090913 0.311553492110119 no 2314 0.319108250559574 3302 25236499
SGTC_2282 7944268 200 µM -0.470414081804799 0.311474960353281 no 2315 0.319029602672489 3391 2970414
SGTC_1925 st057770 10.1 µM -0.470479460277353 0.311451644976398 no 2316 0.319006252732293 3212 5989122
SGTC_2401 5128683 200 µM -0.471238163946572 0.311181130166445 no 2317 0.318735334048464 3226 708373
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.479386893049217 0.308282163586899 no 2318 0.3158317080449 3480 6728940
SGTC_1130 3454-2858 15.9 µM -0.480037244507602 0.308051307745394 no 2319 0.315600455000627 3262 715628 YIL048W NEO1
SGTC_778 3456-2434 196 µM -0.480761504361257 0.307794305935538 no 2320 0.315343006445975 3346 5539063
SGTC_2301 7769476 200 µM -0.481370687228414 0.307578211892587 no 2321 0.315126533049956 3280 977820
SGTC_1380 2291-0730 164 µM -0.481951189092619 0.307372353905574 no 2322 0.314920310517815 3284 2999191
SGTC_764 1951-2361 146 µM -0.483136471868269 0.306952216528709 no 2323 0.314499419556004 3243 5438930
SGTC_1154 4088-0362 150 µM -0.48390864819117 0.306678645845889 no 2324 0.31422535125852 3296 6618304
SGTC_1999 st074831 12.5 µM -0.484550496306807 0.30645133045333 no 2325 0.313997618231209 3238 17112523
SGTC_1065 prochlorperazine maleate 2.48 µM -0.488311867667603 0.305120711075122 no 2326 0.312664478335244 3373 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1972 st070201 17.4 µM -0.489504290324595 0.304699416765431 no 2327 0.312242358927965 3368 2829099
SGTC_2798 7813637 45.45 µM -0.49111753920859 0.304129852610613 no 2328 0.311671658542541 3368 956368
SGTC_3160 9100216 49.47 µM -0.491181305201664 0.30410734951374 no 2329 0.311649110063542 3312 17191039
SGTC_1622 st003707 19.4 µM -0.492358982318037 0.303691879295299 no 2330 0.311232795258187 3361 10140899
SGTC_1193 1488-0126 41.5 µM -0.494213696751084 0.303038072744026 no 2331 0.310577633823331 3281 1384710
SGTC_2705 st078069 42.8 µM -0.494342673402565 0.302992630531743 no 2332 0.310532096267159 3317 1530061
SGTC_14 0354-0009 295 µM -0.495878599509451 0.302451713805952 no 2333 0.30999003289008 3286 1713507
SGTC_1333 1482-0047 286 µM -0.49632363038408 0.302295065437689 no 2334 0.3098330484075 3379 3811116
SGTC_728 3030-5151 22.5 µM -0.497600346852889 0.301845870555423 no 2335 0.309382879614115 3301 3125388
SGTC_1352 1496-0991 99 µM -0.498561194001488 0.301508007848333 no 2336 0.309044274506963 3287 3000039
SGTC_2612 dictamnine 15.46 µM -0.499138222913929 0.301305188974689 no 2337 0.308841005895402 3307 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_507 nimesulide 162 µM -0.499584168778237 0.301148486349983 no 2338 0.308683953697188 3434 4495 A COX2 inhibitor.
SGTC_2997 9067075 71.4286 µM -0.499798321942277 0.301073247302985 no 2339 0.308608546156899 3336 27209819
SGTC_1834 st055981 52.8 µM -0.50001132650053 0.300998420204025 no 2340 0.308533551069168 3416 471719 YDL150W RPC53
SGTC_527 4476-4215 268 µM -0.500749506975426 0.300739167160791 no 2341 0.308273712770411 3255 4418754
SGTC_1138 3761-0006 1.03 µM -0.501559282158698 0.300454885615369 no 2342 0.307988783709454 3370 12061087
SGTC_1393 3470-5649 58.2 µM -0.503540621466132 0.299759824467431 no 2343 0.307292113995471 3320 4108395
SGTC_759 3486-0358 89.3 µM -0.503946896190282 0.299617391806648 no 2344 0.307149347247474 3432 875103
SGTC_2131 toluylene red 5.2905 µM -0.505040851318641 0.299234023219533 no 2345 0.306765071894249 3287 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_440 fluspirilene 35.1 µM -0.505461139968015 0.299086795335346 no 2346 0.30661749285189 3451 3396 An atypical antipsychotic.
SGTC_1094 duloxetine 25.4 µM -0.506076425344041 0.298871319073037 no 2347 0.306401499719964 3286 60834 A selective serotonin reuptake inhibitor.
SGTC_2456 5770359 74.46 µM -0.506818611532796 0.29861149535394 no 2348 0.306141048120534 3408 3118787
SGTC_899 1083-0020 478 µM -0.508696079930116 0.297954692338402 no 2349 0.305482635282575 3428 767123
SGTC_1636 st007707 68.9 µM -0.50987622630318 0.297542173921076 no 2350 0.30506908918666 3458 403051
SGTC_1778 st046819 58.9 µM -0.510633500427693 0.297277607283046 no 2351 0.304803856701524 3299 671715
SGTC_295 k015-0027 31 µM -0.511001539875766 0.297149065251307 no 2352 0.304674989256069 3353 3887424
SGTC_1883 5-benzylidenerhodanine 20 µM -0.511378727867187 0.297017354356897 no 2353 0.304542943631957 3364 1273210
SGTC_3346 9158254 43.5805 µM -0.513062866945762 0.296429593123356 no 2354 0.303953672686824 3347 17639500
SGTC_237 nikkomycin 200 µM -0.513344861087121 0.296331229850667 no 2355 0.303855054207934 3432 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1799 st045822 46.1415 µM -0.514869299844276 0.295799744845738 no 2356 0.303322177572757 3403 3674992
SGTC_476 mead acid 10 µM -0.515425937973056 0.29560578602258 no 2357 0.303127705557469 3308 5312531 An omega 9 fatty acid.
SGTC_1041 0206-0046 107 µM -0.516149691488049 0.29535368383055 no 2358 0.302874932064913 3331 50494
SGTC_925 2064-1272 59.6 µM -0.516687476381047 0.295166423438551 no 2359 0.302687169908934 3299 6815817
SGTC_884 0851-0618 334 µM -0.516958477686999 0.295072079641978 no 2360 0.302592572308567 3396 9642473
SGTC_3231 9132313 49.47 µM -0.517385716422206 0.294923373059114 no 2361 0.302443464300742 3347 4905967
SGTC_1495 4469-0029 237 µM -0.517877235109856 0.294752335648155 no 2362 0.302271963103496 3376 793680
SGTC_2782 7736369 71.43 µM -0.518015471646596 0.294704240694843 no 2363 0.302223737334438 3323 2950836 YOL077C BRX1
SGTC_2789 5281112 71.43 µM -0.51971165853064 0.294114401948083 no 2364 0.301632279922366 3325 765948
SGTC_2854 9024559 71.43 µM -0.519787136085612 0.294088167767595 no 2365 0.301605973132504 3355 3163529
SGTC_1355 1499-0035 1.68 µM -0.522228563095565 0.293240170451745 no 2366 0.300755600466779 3342 1548538
SGTC_971 1315-0384 26.7 µM -0.52239493070381 0.293182426143524 no 2367 0.300697692409529 3333 6769120
SGTC_33 0986-0033 35.816 µM -0.522813641485155 0.293037119721928 no 2368 0.300551972804184 3377 2848082
SGTC_2524 avocatin b 10.57 µM -0.526808339605016 0.291652510850078 no 2369 0.299163345498952 3355 6710748
SGTC_2770 toltrazuril 17.5 µM -0.527373676909325 0.291456804960475 no 2370 0.298967059741533 3422 68591 Kills coccidiodes.
SGTC_848 0368-0089 85.6 µM -0.530776613410077 0.290280088075693 no 2371 0.297786794020663 3404 762535
SGTC_805 3852-0218 479 µM -0.531443247688737 0.290049830488753 no 2372 0.297555829487643 3312 6615355
SGTC_218 alverine citrate 93.75 µM -0.531846769004182 0.289910494560419 no 2373 0.297416063771154 3439 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2006 4011487 200 µM -0.532372258095864 0.28972909022466 no 2374 0.297234097631581 3465 45595294
SGTC_2101 5377231 179.231 µM -0.533977258230157 0.289175357431904 no 2375 0.29667863416075 3420 2844213
SGTC_514 4466-0038 2.65 nM -0.534380270855108 0.289036394326367 no 2376 0.296539232993093 3342 5722064
SGTC_610 4215-0184 155 µM -0.536545013829107 0.288290505606714 no 2377 0.295790967298534 3410 5605015
SGTC_2546 rhodinyl acetate 100 µM -0.538430083357639 0.287641722116765 no 2378 0.295140081037035 3439 6708682
SGTC_1486 3970-0793 4.53 µM -0.539264613745373 0.287354722723166 no 2379 0.294852140966396 3433 2844330
SGTC_1194 1488-0194 225 µM -0.539759767724207 0.287184500724515 no 2380 0.294681358001348 3339 1391452
SGTC_1072 oxiconazole 14.9 nM -0.540439266415184 0.286950983184237 no 2381 0.29444706721604 3430 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_956 1185-0240 191 µM -0.541785156053146 0.286488718454627 no 2382 0.293983259196744 3349 1416193
SGTC_2654 protoveratrine a 100 µM -0.542205881485165 0.2863442869113 no 2383 0.293838342027755 3369 5702278 A heart drug and vasodilator.
SGTC_103 0844-0104 51.839 µM -0.54232100668185 0.286304771412427 no 2384 0.293798693379798 3470 5375804
SGTC_272 doxorubicin 8.13 µM -0.543311840276489 0.285964785398179 no 2385 0.293457556703663 3421 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.543399778591411 0.285934620284306 no 2386 0.293427289059255 3371 688664
SGTC_1491 4138-0063 26.5 µM -0.545151931527868 0.285333902110367 no 2387 0.292824514155103 3415 23883227
SGTC_1628 st004252 77.7 µM -0.545235504610831 0.285305264461547 no 2388 0.292795777747811 3438 692968
SGTC_1784 st039334 36.3 µM -0.545629991892097 0.285170105595883 no 2389 0.292660151907457 3515 3496984
SGTC_2661 dactinomycin 12.96 µM -0.545636138958922 0.285167999735042 no 2390 0.292658038759465 3387 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_697 0508-1955 564 µM -0.546735459197086 0.284791514076293 no 2391 0.292280244685099 3466 6243113
SGTC_2063 5246145 200 µM -0.550826456366269 0.283392552487724 no 2392 0.290876323094858 3460 711240
SGTC_45 0kpi-0036 14.9 µM -0.55337365517261 0.282523177315663 no 2393 0.290003787394897 3454 2795021
SGTC_900 1112-0045 141 µM -0.554075578769342 0.282283831889582 no 2394 0.289763561300858 3400 56211 YIL048W NEO1
SGTC_1292 0kpi-0043 232 µM -0.554663325759433 0.282083494057911 no 2395 0.28956248282111 3408 3333905
SGTC_99 0109-0120 622.8 µM -0.555730646063476 0.281719865316029 no 2396 0.289197501570212 3517 759414
SGTC_2400 5203494 178.7 µM -0.556230403744633 0.281549678996709 no 2397 0.28902667862178 3447 6777674
SGTC_1211 1056-0033 32.3 µM -0.556371727586668 0.281501561899986 no 2398 0.288978381110294 3469 6741922
SGTC_2839 9003951 25.97 µM -0.557603555528631 0.281082324563261 no 2399 0.288557564016134 3448 2990634
SGTC_2146 5545642 200 µM -0.5584098790911 0.280808065791646 no 2400 0.288282264183536 3471 825326
SGTC_3111 9122088 49.47 µM -0.561053597563053 0.279909753618242 no 2401 0.28738049988635 3359 16876704
SGTC_1119 parthenolide 318.541 nM -0.561748682377094 0.279673801520263 no 2402 0.287143630303642 3533 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_428 3448-4153 16.5 µM -0.56189596642772 0.279623817168287 no 2403 0.287093451016063 3312 3834874
SGTC_35 0133-0054 64.071 µM -0.562376457860614 0.279460781106411 no 2404 0.286929777727428 3400 99677
SGTC_1231 0242-0792 125 µM -0.564205515824114 0.278840584185299 no 2405 0.286307137204223 3420 3707635
SGTC_2023 5144124 124 µM -0.564760395190427 0.278652568211028 no 2406 0.286118374312437 3377 2830192
SGTC_2825 7998094 58.44 µM -0.565102071632852 0.278536824882051 no 2407 0.286002169759133 3401 2987815
SGTC_1185 1319-0113 81.3 µM -0.565864935299383 0.278278488389994 no 2408 0.285742799921302 3457 4672763
SGTC_3281 9140613 49.47 µM -0.565926371639046 0.278257688643966 no 2409 0.28572191674167 3405 16013766
SGTC_2212 7123476 200 µM -0.566428572996658 0.278087692933465 no 2410 0.285551237819287 3422 1085715
SGTC_2371 9071574 200 µM -0.566448046960899 0.278081101995699 no 2411 0.285544620345503 3453 45596039
SGTC_2487 5918373 44.05 µM -0.567357772374008 0.277773291576125 no 2412 0.285235566722509 3529 2876279
SGTC_869 0564-0080 44.1 µM -0.567591107398943 0.277694368250515 no 2413 0.285156323400735 3424 6843321
SGTC_1456 k015-0012 13 µM -0.568890043374274 0.277255215968982 no 2414 0.284715381346186 3541 2989616
SGTC_1318 1280-3875 124 µM -0.569123361898225 0.277176370206853 no 2415 0.284636212590108 3451 373245
SGTC_179 1273-0063 6.77 µM -0.569143245637807 0.277169651365113 no 2416 0.284629466201105 3370 3108139
SGTC_3096 9117468 49.47 µM -0.569707016807984 0.276979182676479 no 2417 0.284438215065528 3414 41316311
SGTC_1851 st056236 18.9 µM -0.570176616691035 0.276820578454692 no 2418 0.284278957047347 3520 5393171
SGTC_389 tpck 16.7 µM -0.570212999858265 0.276808292140141 no 2419 0.284266620000974 3437 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2583 asiatic acid 100 µM -0.571912772785984 0.276234589877479 no 2420 0.283690535170606 3516 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2806 7952793 58.44 µM -0.573277760364614 0.275774306175119 no 2421 0.283228320539528 3470 2972490
SGTC_1789 tunicamycin 25 nM -0.574029033869666 0.27552113222035 no 2422 0.282974077129766 3494 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2445 5742597 35.57 µM -0.575673052840935 0.274967508348673 no 2423 0.28241809639407 3369 1774255
SGTC_352 k048-0007 5.11 µM -0.575981439281296 0.274863720206426 no 2424 0.2823138636181 3465 6811911
SGTC_876 0720-0963 56.8 µM -0.579108098508163 0.273812527677205 no 2425 0.281258117951585 3527 765861
SGTC_1183 1254-0324 198 µM -0.581561628485874 0.272989037735474 no 2426 0.280430997695118 3511 5799357
SGTC_2951 9072950 58.06 µM -0.581570170764552 0.272986172796184 no 2427 0.280428120028351 3527 16488155
SGTC_1781 st038725 66.3 µM -0.581599844115017 0.272976220959985 no 2428 0.280418123975916 3413 4270275 YIL048W NEO1
SGTC_2669 eugenol 100 µM -0.581680866376049 0.272949048663207 no 2429 0.280390830910396 3465 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1002 4049-0206 172 µM -0.582193309411234 0.272777222592722 no 2430 0.280218239739048 3469 4662749
SGTC_3081 9117243 49.47 µM -0.582293614596234 0.272743595777844 no 2431 0.280184462906816 3535 45595589
SGTC_1924 st058459 75.1 µM -0.582507080786146 0.272672039145331 no 2432 0.280112586732154 3463 688683
SGTC_2372 9071633 200 µM -0.582611527522458 0.272637030640993 no 2433 0.280077421740368 3516 21321366
SGTC_1118 chelidonine 707.474 nM -0.583274429681473 0.272414890820583 no 2434 0.279854286599065 3519 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3003 9075612 71.4286 µM -0.583651751161491 0.272288489807904 no 2435 0.279727317412676 3484 6501993
SGTC_1230 0170-0365 3.77 µM -0.585026395865348 0.2718282365856 no 2436 0.279264984178098 3574 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_599 1935-0052 86.5 µM -0.588455643462283 0.270681759196435 no 2437 0.278113249166644 3442 9557311
SGTC_2551 apiole 73.87 µM -0.590433608688648 0.270021579131108 no 2438 0.277449991993142 3405 10659 A possible DNA adduct former.
SGTC_2659 sanguinarine 24.21 µM -0.590824276007593 0.26989128250907 no 2439 0.27731908376358 3443 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_963 1269-2853 151 µM -0.592248779888247 0.26941644415884 no 2440 0.276842004542972 3456 3668223
SGTC_2263 7948595 193.29 µM -0.592710273014415 0.26926270177755 no 2441 0.276687532577643 3491 2971371
SGTC_1567 st069303 68.4 µM -0.593147932965877 0.269116939872879 no 2442 0.276541077133983 3519 5581319
SGTC_1916 st067606 49.2 µM -0.593166445393081 0.269110775213293 no 2443 0.276534883103589 3471 19590279
SGTC_775 4577-0580 57.3 µM -0.594474382728336 0.268675410010284 no 2444 0.276097435602706 3579 2006902
SGTC_3232 9132874 49.47 µM -0.596334555769453 0.268056835617334 no 2445 0.275475875303705 3455 3784940
SGTC_2339 9000433 200 µM -0.597430340041584 0.267692783814598 no 2446 0.275110051165061 3435 2988954
SGTC_1664 st014217 9.02 µM -0.597494782504526 0.267671381891079 no 2447 0.275088544702184 3574 3982782
SGTC_913 3487-1245 167 µM -0.597505094299987 0.267667957330785 no 2448 0.27508510341078 3448 4016153
SGTC_2068 5226020 147 µM -0.597889567531499 0.267540289047668 no 2449 0.274956810684018 3494 1810509
SGTC_2295 7971645 200 µM -0.59867026090394 0.267281146301204 no 2450 0.274696396211595 3464 2978226 YKL099C UTP11
SGTC_2337 9009472 200 µM -0.598763750918499 0.267250121793175 no 2451 0.274665219073452 3578 5742383
SGTC_2549 cedrol 20.94 µM -0.600427781594254 0.26669822015726 no 2452 0.274110588694726 3489 6708665 A sedative which affects the nervous system.
SGTC_3235 9132602 49.47 µM -0.600433120107208 0.266696450484036 no 2453 0.274108810230416 3558 4912240
SGTC_943 3253-1379 105 µM -0.600470726309314 0.266683984504904 no 2454 0.274096282317386 3531 668464
SGTC_445 e6 berbamine 66 µM -0.60065870046717 0.266621677871407 no 2455 0.274033665933108 3524 6610268 A calcium/calmodulin antagonist.
SGTC_2174 5790901 200 µM -0.602253052705821 0.266093503909691 no 2456 0.2735028530219 3511 786020
SGTC_3012 9080433 71.4286 µM -0.603245469815125 0.265765005636052 no 2457 0.273172701536205 3540 17688859
SGTC_2320 7373003 200 µM -0.603319145208531 0.265740626671136 no 2458 0.27314819951619 3515 5415828
SGTC_2699 st077704 54.6 µM -0.603632830824664 0.265636841740158 no 2459 0.273043890156934 3495 645852
SGTC_406 estrone 100 µM -0.60363795660002 0.265635146014667 no 2460 0.273042185855305 3555 5870 A steroid.
SGTC_354 2783-3500 4.88 µM -0.604093764827439 0.265484376022492 no 2461 0.272890652367888 3462 6740761
SGTC_3285 9112818 20.8695 µM -0.604506900274788 0.265347758641065 no 2462 0.272753341492965 3536 17017947 YPR165W RHO1
SGTC_1525 8-methoxypsoralen 92.5 µM -0.607380787424694 0.264398397946826 no 2463 0.271799117842837 3590 4114 Related to psoralen; DNA damaging agent.
SGTC_467 ro 31-8220 72.8 µM -0.607456146223398 0.264373527181897 no 2464 0.271774118649468 3449 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2513 baicalein 25.65 µM -0.607870964983975 0.264236645316091 no 2465 0.271636529004619 3484 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_871 0574-0004 149 µM -0.608767537367605 0.26394091777835 no 2466 0.271339266881185 3442 9551173
SGTC_409 arachidonic acid 100 µM -0.609035202394741 0.263852663228983 no 2467 0.271250552915471 3546 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1261 0712-0010 12.7 µM -0.609945134045905 0.263552752992581 no 2468 0.270949076496538 3572 2840123
SGTC_2099 5377090 177.372 µM -0.611553838011172 0.263022955853446 no 2469 0.270416493858084 3508 2243829
SGTC_3288 9119690 36.221 µM -0.612821837030503 0.262605747585129 no 2470 0.26999707511307 3490 17595618 YKL019W RAM2
SGTC_1609 st001574 46.4 µM -0.615049608397416 0.261873567572608 no 2471 0.269260979676309 3462 3960012
SGTC_994 3910-0338 138 µM -0.615132893914415 0.261846215244861 no 2472 0.269233480184867 3592 3479481
SGTC_197 4544-0043 41.561 µM -0.615136047817125 0.261845179480355 no 2473 0.269232438846372 3532 896523
SGTC_2438 5259590 200 µM -0.61638443818753 0.261435364133273 no 2474 0.268820410814786 3503 1201127
SGTC_149 3970-0822 46.1 µM -0.616886474222067 0.261270651164281 no 2475 0.268654804443291 3590 3114250 YBL034C STU1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.621214905575602 0.259852751139556 no 2476 0.267229116721119 3560 4213774
SGTC_2576 guaiol 23.12 µM -0.621252138015295 0.259840571845101 no 2477 0.267216869778319 3539 227829
SGTC_1105 epirubicin 18.1 µM -0.621684623060199 0.259699121024621 no 2478 0.267074632343771 3474 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3202 9113761 49.47 µM -0.622708878265903 0.259364281352442 no 2479 0.266737923685608 3547 4798415
SGTC_1824 st053723 68.6 µM -0.623615845490928 0.259067970646186 no 2480 0.266439950919009 3535 675225
SGTC_1755 st041960 45.185 µM -0.623776385917172 0.259015539530348 no 2481 0.266387224911679 3558 2257073
SGTC_1730 st033808 45.1 µM -0.626514103070727 0.258122270249154 no 2482 0.265488894731497 3540 1045166
SGTC_2982 9019404 25.97 µM -0.62704055514879 0.257950681431095 no 2483 0.265316325783136 3459 22333232
SGTC_309 k408-0051 1.48 µM -0.628042850497251 0.257624162593239 no 2484 0.264987934726461 3547 3640463
SGTC_2399 5884133 200 µM -0.628479463064553 0.257481993983491 no 2485 0.264844948022077 3557 722445
SGTC_42 0133-0086 60.653 µM -0.628529518991386 0.257465697511704 no 2486 0.264828557660782 3528 162923 Model of phenazepam hydroxylation.
SGTC_1249 0481-0015 10.2 µM -0.62952194203559 0.25714270968499 no 2487 0.264503704187444 3517 4227577
SGTC_977 1348-1378 135 µM -0.629536310639101 0.257138034916516 no 2488 0.264499002349327 3559 X977
SGTC_1987 st072290 61.9 µM -0.630076602060718 0.256962285311995 no 2489 0.26432223366019 3525 54697379
SGTC_3335 9143315 29.6265 µM -0.630171580752022 0.256931396468403 no 2490 0.264291165427332 3497 4899691
SGTC_1160 4092-0570 10.5 µM -0.63045280176071 0.256839949476037 no 2491 0.264199186858395 3569 4994975
SGTC_873 0591-4978 488 µM -0.631105411616215 0.256627800144356 no 2492 0.263985801483801 3638 3305145
SGTC_2223 6903751 107.57 µM -0.63188739568181 0.256373714295007 no 2493 0.263730230048336 3534 5598863
SGTC_2860 9025725 38.96 µM -0.632509506905206 0.256171668740583 no 2494 0.263526999120364 3483 40546248
SGTC_3033 9090887 49.47 µM -0.633648542358074 0.255801954925402 no 2495 0.263155106931286 3535 19325384
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.635859634722698 0.255085063440561 no 2496 0.262433957101689 3458 88881 An O-methylated flavonoid and antioxidant.
SGTC_2318 6029776 164 µM -0.635868218927591 0.25508228227582 no 2497 0.262431159328324 3603 818325
SGTC_2103 5378138 10 µM -0.636832512398182 0.254769965399604 no 2498 0.262116972994993 3619 244142
SGTC_169 k015-0017 16.025 µM -0.636912025630712 0.254744221467064 no 2499 0.262091074579788 3633 1840002
SGTC_1521 st012942 49.4 µM -0.63705040595859 0.254699421432531 no 2500 0.262046005571837 3591 24207259
SGTC_182 3448-4371 550.524 µM -0.63779994466675 0.254456833219292 no 2501 0.261801957801218 3600 3491403
SGTC_1270 0831-1170 17.3 µM -0.639412163660146 0.253935449097269 no 2502 0.261277419042153 3578 6764716
SGTC_2365 9042475 200 µM -0.639571584887233 0.253883923490995 no 2503 0.261225580368636 3571 6464479
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.642566712762197 0.252916906574119 no 2504 0.260252644055785 3598 66535 A nucleotide analog.
SGTC_2369 9071472 200 µM -0.643517128840213 0.252610457749441 no 2505 0.259944301963967 3596 17296037
SGTC_559 1550-0661 158 µM -0.643820401829828 0.25251271265107 no 2506 0.259845951222828 3586 5830875
SGTC_1717 st033143 58.0435 µM -0.644123714538587 0.252414974687091 no 2507 0.25974760680607 3615 674616
SGTC_68 0986-0284 82.829 µM -0.644447567076515 0.252310640085543 no 2508 0.259642623877373 3560 423278 YIL048W NEO1
SGTC_2597 laccaic acid a 100 µM -0.644524696573897 0.252285794859251 no 2509 0.259617624121168 3550 5491415 A textile dye.
SGTC_2389 9091542 195.52 µM -0.646283967661057 0.251719442679196 no 2510 0.259047734404363 3578 3626624 YOL127W RPL25
SGTC_569 4130-2812 160 µM -0.646510347441671 0.251646614305158 no 2511 0.258974449044714 3512 743552
SGTC_792 4534-1957 155 µM -0.647932013579919 0.251189506288315 no 2512 0.258514461878677 3554 1717904
SGTC_2022 5136654 200 µM -0.648952307221472 0.250861722354741 no 2513 0.258184601795991 3586 1713771
SGTC_249 wiskostatin 11.211 µM -0.649464532684311 0.25069724800562 no 2514 0.25801908203997 3607 2775510 A n-wasp and actin depolymerizer.
SGTC_655 k060-0012 42 µM -0.649482478785392 0.250691486591916 no 2515 0.258013283962275 3532 5994525
SGTC_219 mitoxanthrone 164.414 µM -0.65022048482242 0.250454617989002 no 2516 0.257774905405601 3564 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_425 3825-7017 13.1 µM -0.651638965270023 0.249999679274407 no 2517 0.257317052422354 3641 3397440
SGTC_2497 7-hydroxyflavone 100 µM -0.652116114073609 0.249846745496141 no 2518 0.257163134775696 3596 5281894
SGTC_580 1123-0028 41 µM -0.653078629091475 0.249538395331365 no 2519 0.256852794472091 3659 1677248 YPR107C YTH1
SGTC_1284 0929-0043 16 µM -0.653291886676937 0.249470103757662 no 2520 0.256784060970448 3566 1239883
SGTC_1581 himbacine 57.9 µM -0.655832110868363 0.248657410926479 no 2521 0.255966076600755 3607 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_914 3820-6779 408 µM -0.6560185338727 0.248597824284343 no 2522 0.255906099624459 3574 2893481
SGTC_2885 9057732 51.95 µM -0.661137227733549 0.246964705047321 no 2523 0.254262156439106 3635 6471414
SGTC_1334 1486-0610 236 µM -0.662051753681745 0.246673531211207 no 2524 0.253969027184497 3610 3742339
SGTC_976 1348-1067 47.6 µM -0.662422644730452 0.246555496474809 no 2525 0.253850197557683 3659 5310671 YGL099W LSG1
SGTC_595 3909-8003 73.7 µM -0.663464554243026 0.246224074488792 no 2526 0.253516536823174 3643 699517
SGTC_1680 diphenhydramine 100 µM -0.666032803982835 0.245408158637551 no 2527 0.25269506649232 3617 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.667872009555802 0.244824749296613 no 2528 0.25210764792027 3632 688669
SGTC_2933 9026794 32.47 µM -0.670218968480344 0.244081362349645 no 2529 0.251359106828431 3625 17586027
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.670267363110439 0.244066046424873 no 2530 0.251343684175854 3606 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2424 5537928 59.2 µM -0.670334242197277 0.244044881395374 no 2531 0.251322371623775 3671 5382802
SGTC_2347 9049783 174.81 µM -0.670615201235256 0.243955977924704 no 2532 0.251232848032954 3626 6467988 YPL169C MEX67
SGTC_72 0744-0168 198.391 µM -0.672150686194566 0.243470415434468 no 2533 0.250743885714166 3572 677577
SGTC_276 colchicine 750 µM -0.672945645264938 0.243219232831403 no 2534 0.250490935784096 3663 2833 A microtubule depolymerizer.
SGTC_2874 9043904 71.43 µM -0.674782157712558 0.242639487452186 no 2535 0.249907088905448 3588 4463428
SGTC_41 0478-0632 82.643 µM -0.674783379713135 0.242639101943539 no 2536 0.24990670065905 3641 3750424
SGTC_2350 9023895 38.85 µM -0.675837267532324 0.242306751902186 no 2537 0.249571985226735 3639 2997209
SGTC_2891 9063876 19.48 µM -0.67588273559326 0.242292418821414 no 2538 0.249557549903318 3600 6472478
SGTC_2142 5622915 118.518 µM -0.675975489854889 0.242263180945127 no 2539 0.249528103404076 3625 5322196
SGTC_2569 tetrandrine 100 µM -0.676535336932893 0.242086747296252 no 2540 0.249350409142996 3613 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.679832144921738 0.241049185596656 no 2541 0.248305375213574 3653 115019
SGTC_826 1683-5028 118 µM -0.680795841338238 0.2407463512505 no 2542 0.248000340920757 3668 722377
SGTC_2742 clothiapine 36.27 µM -0.681185321856511 0.240624018701904 no 2543 0.24787711724277 3597 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_186 3455-3465 67.277 µM -0.681468146812641 0.240535206979164 no 2544 0.247787657691479 3602 755278
SGTC_3093 9117344 49.47 µM -0.683656531606026 0.239848621618847 no 2545 0.247096039055108 3643 24824913
SGTC_1157 4092-0394 27.6 µM -0.683823486566209 0.239796284981329 no 2546 0.247043316922409 3736 3659885
SGTC_727 3032-0951 202 µM -0.684123994883286 0.239702098062389 no 2547 0.246948435601519 3627 3652836
SGTC_2167 5876490 200 µM -0.68441569827391 0.239610690143606 no 2548 0.24685635296896 3712 686534
SGTC_1111 tnp00062 510.699 nM -0.685573402133898 0.239248100750464 no 2549 0.246491079405553 3696 676306
SGTC_1029 k015-0030 64.7 µM -0.686055133885048 0.239097312175738 no 2550 0.246339170918175 3688 2208316
SGTC_2751 anetholtrithion 17.25 µM -0.686848341273311 0.238849140724394 no 2551 0.246089151604388 3628 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2046 4110841 106 µM -0.687074032512656 0.238778554274785 no 2552 0.246018038509385 3664 44119630 YMR134W ERG29
SGTC_674 0498-0004 451 µM -0.689136997708041 0.238133877245533 no 2553 0.245368529689497 3632 4231473
SGTC_1058 3448-5425 97.3 µM -0.68983565772091 0.237915762257349 no 2554 0.245148771019162 3595 7279705
SGTC_3042 9091578 49.47 µM -0.690360333154304 0.237752035638994 no 2555 0.244983807609705 3622 25236497
SGTC_222 nsc-310342 10.666 µM -0.693375758195913 0.23681226214897 no 2556 0.244036885682215 3626 432556
SGTC_1167 k781-0610 148 µM -0.693780537231879 0.236686266265233 no 2557 0.243909924997702 3698 4525169
SGTC_1265 0819-1001 68.8 µM -0.694203034722629 0.236554794484928 no 2558 0.243777444867801 3668 3106768
SGTC_3021 9087658 49.47 µM -0.694376534688253 0.236500816813194 no 2559 0.243723052724717 3638 25237042
SGTC_1140 3229-1848 2.98 µM -0.694656555632594 0.236413713640055 no 2560 0.243635280135961 3673 2849525
SGTC_420 mitomycin C 81.9 mM -0.694721884997364 0.236393394861734 no 2561 0.243614805096937 3655 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1096 rimcazole 32.2 µM -0.696131905997375 0.235955083649059 no 2562 0.243173113445512 3609 18528119 A dopamine reuptake inhibitor.
SGTC_2999 9069765 71.4286 µM -0.696234524477558 0.235923201738463 no 2563 0.243140984930073 3688 2097066
SGTC_729 4092-0585 94.1 µM -0.69712512357879 0.235646606673304 no 2564 0.242862246324548 3662 2169061
SGTC_1359 1582-0056 520 nM -0.698090299188864 0.235347052303053 no 2565 0.242560362199603 3716 3661189
SGTC_2664 lyso-paf C-16 73.48 µM -0.69922524300023 0.234995077310362 no 2566 0.242205638731778 3670 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_416 estradiol valerate 100 µM -0.699986558245068 0.234759137130659 no 2567 0.241967849483668 3684 13791 A steroid.
SGTC_2639 lactacystin 53 µM -0.700614910515862 0.234564502368236 no 2568 0.241771685325752 3707 3870 A proteasome inhibitor.
SGTC_3332 9141069 11.198 µM -0.701215058456427 0.2343786873828 no 2569 0.241584406838842 3640 17332883
SGTC_2327 6189656 200 µM -0.701645250124492 0.234245543597257 no 2570 0.241450212346736 3728 5349088
SGTC_2358 9037157 4 µM -0.70201955566829 0.234129730570112 no 2571 0.241333483986408 3690 2388925
SGTC_2879 9041815 71.43 µM -0.702307720647842 0.234040591704641 no 2572 0.241243639725283 3632 4942971
SGTC_395 anisomycin 6.25 µM -0.704806646068076 0.233268381026437 no 2573 0.240465286010729 3663 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1827 berberine 7.24 µM -0.705373755894019 0.233093331464675 no 2574 0.240288835870329 3632 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1771 st048882 4.1505 µM -0.705743782286104 0.232979154898233 no 2575 0.240173744169553 3679 4580403
SGTC_1553 gossypol 38.6 µM -0.705919691836469 0.232924886561237 no 2576 0.240119040423527 3595 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2444 5485484 36.41 µM -0.706453346019097 0.232760296484916 no 2577 0.239953128047756 3746 6790631
SGTC_1247 0448-0043 5.84 µM -0.707253179042958 0.232513732374099 no 2578 0.23970457813742 3742 3089013 YGL099W LSG1
SGTC_3009 9080819 71.4286 µM -0.70739440469112 0.232470211907817 no 2579 0.23966070654795 3704 17027216
SGTC_2048 5246248 200 µM -0.708162071888942 0.232233724825617 no 2580 0.239422308263205 3676 677046
SGTC_2460 5552655 174.22 µM -0.711720053463576 0.23113940512274 no 2581 0.23831907360883 3672 5401989
SGTC_1770 st043884 66.3 µM -0.712795808524055 0.230809105180489 no 2582 0.237986059839403 3692 670149
SGTC_454 lyso-paf C-16 6.67 µM -0.712812988966423 0.230803832235219 no 2583 0.237980743483561 3635 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2096 5468907 200 µM -0.713709608592213 0.230528739105722 no 2584 0.237703381811241 3730 759785
SGTC_3176 9106582 49.47 µM -0.713804919924592 0.230499507280686 no 2585 0.237673908490669 3590 17018027
SGTC_3226 9131256 49.47 µM -0.717010241136377 0.229517647925336 no 2586 0.236683888791496 3607 17178073
SGTC_1466 k213-0079 57.5 µM -0.718990089974187 0.228912350052369 no 2587 0.236073512862107 3666 3657981
SGTC_2216 7189485 200 µM -0.72066325015594 0.228401515100465 no 2588 0.235558364142585 3697 731273
SGTC_1133 3473-0247 50 µM -0.72147978109911 0.22815245162808 no 2589 0.235307188065091 3728 711311
SGTC_1748 st037455 53.6035 µM -0.721875072095213 0.22803193232932 no 2590 0.235185644288103 3707 580690
SGTC_761 k216-0224 480 µM -0.722807772943456 0.227747705429789 no 2591 0.23489899559524 3741 1340404
SGTC_3142 9086498 49.47 µM -0.722930421787547 0.227710344833945 no 2592 0.234861316066349 3679 25236367
SGTC_1192 1488-0095 21.4 µM -0.72359276433542 0.227508645431129 no 2593 0.234657892435085 3738 915875
SGTC_859 0439-0102 54.6 µM -0.724589833886585 0.227205203346955 no 2594 0.234351848744839 3719 610143
SGTC_3251 9135047 49.47 µM -0.724730174111262 0.227162511376573 no 2595 0.234308790012311 3699 17682963
SGTC_2085 5307070 144.047 µM -0.725445376877159 0.226945014531875 no 2596 0.234089421853953 3687 2840351
SGTC_3291 9121177 71.43 µM -0.7267190170745 0.226557984939307 no 2597 0.233699050633769 3701 17015612
SGTC_1446 4239-0190 62 µM -0.728950578457324 0.225880764604703 no 2598 0.233015947114306 3735 1340085
SGTC_2980 9014342 25.29 µM -0.729905842226137 0.225591217373209 no 2599 0.23272387048644 3737 2996599
SGTC_1752 st044819 83.042 µM -0.731464920488732 0.225119101122469 no 2600 0.232247611914725 3714 441209 YML126C ERG13
SGTC_2916 7875993 68.79 µM -0.731615669124653 0.225073481489437 no 2601 0.232201590830148 3691 1299250
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.732048826854891 0.224942428218945 no 2602 0.232069383129156 3723 551469
SGTC_1719 st032227 49.2 µM -0.73368607542952 0.224447464272863 no 2603 0.231570043502825 3756 3125804
SGTC_1520 flindersine 88 µM -0.734515870426264 0.224196841433411 no 2604 0.231317195630492 3805 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2519 cryptotanshinone 88.04 µM -0.734893264974002 0.224082909617676 no 2605 0.231202250228644 3684 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2799 7812892 81.82 µM -0.735141568381266 0.224007967126928 no 2606 0.231126640302029 3715 20205235
SGTC_3101 9120531 49.47 µM -0.735794762883895 0.223810889143202 no 2607 0.230927804435656 3764 24824904
SGTC_3165 9101544 49.47 µM -0.737348891095842 0.223342383176204 no 2608 0.230455103732847 3733 5002184
SGTC_1032 k061-1018 98.7 µM -0.737661664263536 0.223248162390372 no 2609 0.230360036660081 3852 4005393
SGTC_3065 9113888 49.47 µM -0.739499584337764 0.222694958788212 no 2610 0.229801846021457 3772 16648368
SGTC_1505 k297-0037 20.6 µM -0.741313694202161 0.22214968895154 no 2611 0.229251630200683 3744 4089396
SGTC_2941 9056145 11.23 µM -0.741495151278493 0.222095190067091 no 2612 0.229196635306997 3624 2119517
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.741624336439103 0.222056395200006 no 2613 0.229157487172608 3717 688662
SGTC_176 1486-1328 72.834 µM -0.741651312111957 0.222048294776079 no 2614 0.22914931296658 3784 22310231
SGTC_2890 9046729 58.44 µM -0.742152161609079 0.221897927198693 no 2615 0.228997574561418 3673 903329
SGTC_3091 9116372 49.47 µM -0.74224761582021 0.221869276050065 no 2616 0.22896866195243 3783 17169793
SGTC_1237 0330-0133 46.1 µM -0.742875821513657 0.221680769095169 no 2617 0.228778432658144 3680 X1237 YHR072W ERG7
SGTC_1695 st026914 34.495 µM -0.742882727374287 0.221678697348251 no 2618 0.228776341962036 3705 3289191
SGTC_829 1635-0120 117 µM -0.743119405204658 0.221607701072617 no 2619 0.22870469605528 3749 285054
SGTC_2521 angolensin 13.4 µM -0.744222514880402 0.221276972611548 no 2620 0.228370934562613 3772 821428 A flavenoid.
SGTC_3327 9140648 26.9345 µM -0.744517606330492 0.221188547751139 no 2621 0.228281696881872 3736 8029710
SGTC_2138 5575593 77.673 µM -0.744864550845785 0.221084610855292 no 2622 0.228176803551542 3729 762213
SGTC_441 propafenone 146 µM -0.744932852832752 0.221064152385193 no 2623 0.22815615669078 3715 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_526 4469-0568 170 µM -0.745517234409358 0.22088915707077 no 2624 0.227979548188426 3740 2901964
SGTC_1913 st060213 96.1 µM -0.745776961327611 0.220811406308459 no 2625 0.227901079675672 3759 688959
SGTC_2140 5586273 200 µM -0.746172148966495 0.220693134659543 no 2626 0.227781715020989 3721 854421
SGTC_730 1436-0052 41.2 µM -0.746491098005956 0.220597706143664 no 2627 0.227685403556839 3765 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_582 0987-0078 156 µM -0.746770328734487 0.220514180628562 no 2628 0.227601104457722 3801 1625765
SGTC_2015 5119600 184 µM -0.747379502527142 0.220332023065418 no 2629 0.227417257327919 3743 2828786
SGTC_3164 9100705 49.47 µM -0.747638343349865 0.220254649577773 no 2630 0.227339165145146 3740 17174235
SGTC_742 0kpi-0133 140 µM -0.748833551237231 0.219897576518429 no 2631 0.22697876737529 3764 2728852
SGTC_2968 9090663 33.37 µM -0.749422220300608 0.219721831496634 no 2632 0.226801381165852 3751 25236811
SGTC_60 0986-0278 202 µM -0.751496366789534 0.219103245582146 no 2633 0.226176993253104 3591 3110598
SGTC_3244 9134489 49.47 µM -0.751890350077742 0.218985858709873 no 2634 0.226058500890949 3746 16584271
SGTC_211 3455-0679 143.504 µM -0.753855110190656 0.218401000929169 no 2635 0.225468113946406 3772 748649
SGTC_2545 solidagenone 89.61 µM -0.754104712948988 0.218326765167857 no 2636 0.22539317383353 3575 6708572 An anti ulcer agent
SGTC_1468 k284-1086 134 µM -0.755000700612171 0.21806040420931 no 2637 0.225124280921755 3760 15996457
SGTC_385 1494-0393 12.4 µM -0.758033257839102 0.217160270875512 no 2638 0.224215536541462 3776 3090647
SGTC_2717 st081029 62.2815 µM -0.758948467704607 0.21688903760877 no 2639 0.223941691978297 3768 5292846
SGTC_2215 7188065 200 µM -0.759160241947249 0.216826303719699 no 2640 0.223878353024527 3756 940217
SGTC_2205 7238770 200 µM -0.759447272890078 0.216741293284535 no 2641 0.223792522012046 3792 279867
SGTC_3190 9110366 49.47 µM -0.76082284857354 0.21633415434683 no 2642 0.223381442613523 3704 17123768
SGTC_2757 clomiphene 4.22 µM -0.76380234007327 0.215453812542413 no 2643 0.222492521057312 3825 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_609 0986-0026 86.3 µM -0.766241115587691 0.214734783659014 no 2644 0.22176642407093 3755 2848610
SGTC_3189 9110682 49.47 µM -0.766706887210063 0.214597618065494 no 2645 0.221627903935267 3861 17122418
SGTC_1832 st054113 55 µM -0.767706613846008 0.214303379506912 no 2646 0.221330752994376 3736 1251267
SGTC_2278 7948257 134.34 µM -0.768100362254287 0.214187556307446 no 2647 0.221213780861213 3751 1247028
SGTC_1805 st050013 60.3 µM -0.768664145550165 0.214021779862452 no 2648 0.221046357488908 3746 4037144
SGTC_533 1222-0222 6.71 µM -0.768926083836221 0.213944784199823 no 2649 0.220968595912861 3871 3982874
SGTC_2898 9056270 58.44 µM -0.768982681494474 0.21392814967397 no 2650 0.220951795832729 3735 19154699
SGTC_685 1278-0033 54.9 µM -0.769243095070543 0.213851621645966 no 2651 0.220874505785468 3818 3590572
SGTC_345 1362-0200 395 µM -0.769859653598561 0.213670496467277 no 2652 0.220691574598336 3787 1419823
SGTC_2376 9072922 81.32 µM -0.770235590476637 0.213560102105441 no 2653 0.220580077781032 3811 17087968
SGTC_2127 5253358 187.912 µM -0.771019987156448 0.213329870028714 no 2654 0.22034754232244 3736 20612
SGTC_1557 sumaresinolic acid 42.3 µM -0.77322779297351 0.212682623607592 no 2655 0.219693790245503 3745 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_11 0438-0307 1.3 µM -0.773551930373866 0.212587695221084 no 2656 0.219597903953894 3772 4011476
SGTC_3116 9124943 49.47 µM -0.774267418039952 0.212378241795224 no 2657 0.219386333570105 3750 41905195 YPL160W CDC60
SGTC_326 k292-0812 17.5 µM -0.777655057920296 0.211388175107751 no 2658 0.218386196727184 3747 3579357
SGTC_2308 7584454 197.62 µM -0.777827550417535 0.211337835134635 no 2659 0.21833534193094 3813 893577
SGTC_2555 cholic acid 100 µM -0.779464485080472 0.210860464003759 no 2660 0.217853075233003 3842 6708657 Influences liver metabolism.
SGTC_1033 k072-0102 21.3 µM -0.781307811339862 0.210323661595384 no 2661 0.217310738487847 3758 5965931
SGTC_3107 9121808 49.47 µM -0.781460102756495 0.210279348116668 no 2662 0.217265966757451 3710 662681
SGTC_969 1313-0238 134 µM -0.78175493969753 0.210193572584691 no 2663 0.217179303607154 3811 5212874
SGTC_2354 9060492 162 µM -0.782669819495145 0.209927541738556 no 2664 0.216910514781171 3877 6471895
SGTC_1060 3448-7350 82 µM -0.78494138326345 0.209267867442212 no 2665 0.216243968529862 3742 570178
SGTC_2525 harmine 47.85 µM -0.785622448887308 0.209070320345628 no 2666 0.216044354374303 3811 5280953 A monoamine oxidase inhibitor
SGTC_336 4111-0029 111 µM -0.787216762169999 0.208608310031977 no 2667 0.215577493216353 3791 3131175
SGTC_3217 9129673 49.47 µM -0.787658743633224 0.208480336447212 no 2668 0.215448171878364 3805 17248312
SGTC_2315 7733312 200 µM -0.788538809738171 0.208225655492818 no 2669 0.215190803448492 3759 726316
SGTC_1135 dihydrocapsaicin 536.708 nM -0.792151902723783 0.207181993748569 no 2670 0.214136054727079 3749 107982 A Capsaicinoid.
SGTC_1992 st073643 23.3 µM -0.792722295848513 0.207017515800567 no 2671 0.213969818638354 3786 3161292
SGTC_363 0455-0021 3.06 µM -0.792826903300522 0.206987359694343 no 2672 0.213939339865303 3824 4597466
SGTC_485 niflumic acid 177 µM -0.792967833351807 0.206946736664572 no 2673 0.21389828201623 3878 4488 A COX2 inhibitor.
SGTC_725 1497-0963 19 µM -0.793010545664863 0.206934425789487 no 2674 0.213885839332722 3849 3549977
SGTC_941 3237-0776 460 µM -0.79544666889054 0.206232984972769 no 2675 0.213176860941677 3844 760008
SGTC_558 k064-0027 21.3 µM -0.797652269050436 0.205599136704318 no 2676 0.212536154875494 3872 5088526
SGTC_1278 0874-0585 172 µM -0.79801963026986 0.205493676417954 no 2677 0.212429549282595 3887 766306
SGTC_565 1418-0001 44.5 µM -0.798112883306249 0.20546691089876 no 2678 0.212402492892466 3885 2862145
SGTC_1383 3049-0032 20.7 µM -0.798933819496674 0.205231374847748 no 2679 0.212164393769524 3888 712864
SGTC_2255 7941087 197.44 µM -0.800065010505185 0.204907086064324 no 2680 0.211836566078946 3836 935561
SGTC_2678 equilin 100 µM -0.800990220240551 0.204642074441994 no 2681 0.211568653782403 3829 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3293 9120939 62.045 µM -0.803104589599446 0.204037212935913 no 2682 0.210957142593743 3812 934087
SGTC_1769 st044406 64.4 µM -0.803382921207584 0.203957669512352 no 2683 0.210876721665953 3832 670903
SGTC_1066 ketoconazole 628 nM -0.804110520313193 0.203749818798028 no 2684 0.210666574667005 3892 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_31 0508-1974 57.237 µM -0.804519223634746 0.203633121344445 no 2685 0.210548585858669 3783 6810525
SGTC_274 sirtinol 40.1 µM -0.805318019603249 0.203405155466755 no 2686 0.210318092968131 3906 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1298 1079-1278 263 µM -0.809096888197201 0.202328781633196 no 2687 0.209229709026478 3872 2840950
SGTC_2003 4023581 200 µM -0.809364083046076 0.202252802961199 no 2688 0.209152877685723 3888 16641307
SGTC_3199 9111318 49.47 µM -0.810659482865117 0.201884689232458 no 2689 0.208780623630418 3810 8548020
SGTC_3257 9139206 32.98 µM -0.811419591720192 0.201668875980846 no 2690 0.208562375954397 3879 4910041
SGTC_917 harmaline 728.087 nM -0.813766346673435 0.20100344805685 no 2691 0.207889408813288 3864 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_80 0159-0065 512.242 µM -0.815293579821458 0.200571105847879 no 2692 0.207452141424844 3764 1548079
SGTC_483 fpl-64176 144 µM -0.815299084082951 0.200569548665065 no 2693 0.207450566464614 3880 3423
SGTC_2406 ethylparaben 405.7 µM -0.815721257152891 0.200450135446752 no 2694 0.207329789159845 3905 8434 A possible steroid mimic.
SGTC_862 0452-0056 10.2 µM -0.816676191642658 0.200180186267839 no 2695 0.207056750330724 3815 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1115 galangin 695.678 nM -0.817449569446243 0.199961721320736 no 2696 0.206835778934984 3888 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2563 tomatine 8.54 µM -0.818492215243753 0.1996674201638 no 2697 0.206538092691072 3774 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.819648331147403 0.199341395396329 no 2698 0.206208306447072 3811 279621
SGTC_273 hydroxyurea 18.1 mM -0.820352438066689 0.19914299434505 no 2699 0.206007610439465 3924 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1817 st052116 64.4 µM -0.820750904786826 0.199030768361501 no 2700 0.205894084321599 3845 4361398
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.822286531343271 0.19859862404507 no 2701 0.205456920199681 3905 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_593 1203-0218 61.7 µM -0.82392109719392 0.198139259311771 no 2702 0.204992196051582 3892 3666956
SGTC_699 0375-0592 111 µM -0.824265980620402 0.198042418173829 no 2703 0.204894221981717 3890 762578
SGTC_2740 felodipine 17.08 µM -0.824410036287054 0.198001976695814 no 2704 0.204853307065785 3806 3333 L-type calcium channel blocker
SGTC_625 k213-0058 121 µM -0.829082869690899 0.196692854898431 no 2705 0.203528758174085 3934 3655420
SGTC_1758 st042942 75.2445 µM -0.829164179384852 0.19667012201338 no 2706 0.203505755653433 3802 669317
SGTC_2249 haloperidol 116.36 µM -0.830760957970555 0.196224010935919 no 2707 0.203054341149103 3864 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_556 4058-0063 51.5 µM -0.830996603701661 0.196158227771393 no 2708 0.202987773997968 3932 6615692
SGTC_1455 4262-0120 131 µM -0.835662892649917 0.194858336703681 no 2709 0.20167228816387 3988 1529587
SGTC_1678 st019265 80.2 µM -0.836864591098519 0.194524429005241 no 2710 0.201334342834616 3862 5367020
SGTC_1051 3253-3903 78 µM -0.837643457626927 0.194308196825376 no 2711 0.201115489018047 3873 5509239
SGTC_114 0364-0001 490.298 µM -0.839229079754123 0.193868442289989 no 2712 0.200670385951342 3945 4003655
SGTC_1445 4239-0156 97.7 µM -0.839806205738334 0.193708533554895 no 2713 0.200508526704218 3980 4008346
SGTC_1687 st020778 55.3625 µM -0.840246727588921 0.193586528914195 no 2714 0.200385031875771 3888 4259299
SGTC_1811 st050069 61.5 µM -0.842798456681578 0.192880737674294 no 2715 0.199670585648714 3833 3877702
SGTC_2616 abietic acid 100 µM -0.843622764325192 0.192653075985971 no 2716 0.19944011968103 3895 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2953 9074162 66.49 µM -0.843662173508372 0.192642195862045 no 2717 0.199429105385487 3846 16451992
SGTC_2924 9010168 62.78 µM -0.844739394239346 0.192344941198158 no 2718 0.199128179629296 4006 2993929
SGTC_413 propylparaben 100 µM -0.846472752779844 0.19186721718267 no 2719 0.198644533851975 3859 7175 A pharmaceutical preservative.
SGTC_2763 lisinopril 49.32 µM -0.846550871186503 0.191845704400147 no 2720 0.198622753766269 3808 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_379 3970-0972 5.9 µM -0.847074239681234 0.191701613686208 no 2721 0.198476871265805 3894 2898042 YBL034C STU1
SGTC_323 4013-0906 34.3 µM -0.847795844511536 0.191503054436952 no 2722 0.198275838874068 3923 2910086
SGTC_500 h-89 112 µM -0.848115964864326 0.19141500938954 no 2723 0.198186695690155 3932 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2600 tangeritin 87.95 µM -0.848991694901799 0.191174277711366 no 2724 0.197942956801512 3855 68077 A bioactive flavone.
SGTC_2329 6138490 200 µM -0.849740338435872 0.190968628406793 no 2725 0.197734733078532 4037 720019
SGTC_387 norethindrone acetate 66.7 µM -0.849967193212691 0.190906339129493 no 2726 0.197671663040882 3905 541197
SGTC_1988 st071872 53.4 µM -0.850113071172431 0.190866290870672 no 2727 0.197631112556194 3924 16414116
SGTC_2899 9053889 58.44 µM -0.850716264500227 0.190700749350863 no 2728 0.197463493033646 3843 6470052
SGTC_3207 9114163 49.47 µM -0.853597434622735 0.189911251887118 no 2729 0.196664040222873 3918 849233
SGTC_2469 5655019 90.81 µM -0.854440709820479 0.189680558518817 no 2730 0.196430423806019 3981 2788239
SGTC_1112 tnp00069 1.16933 µM -0.854977696446384 0.189533745865787 no 2731 0.196281747612749 3935 145826
SGTC_2965 9082772 38.63 µM -0.856662519211765 0.189073567729602 no 2732 0.195815711530815 3900 16459634
SGTC_592 k241-0073 46.5 µM -0.856727470609871 0.189055841244671 no 2733 0.195797758883652 3902 4230158
SGTC_1055 3448-0672 86 µM -0.857114314161394 0.188950285409397 no 2734 0.195690855538606 3946 748378
SGTC_2309 7664088 163.95 µM -0.858623487008171 0.188538833090748 no 2735 0.195274137880927 3916 704922
SGTC_2162 5663267 200 µM -0.859927386894249 0.188183790452243 no 2736 0.194914535373625 3874 6456493
SGTC_277 nystatin 15.5 µM -0.860746647185865 0.187960922916905 no 2737 0.194688797738624 3894 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_997 3996-0078 137 µM -0.861114648520801 0.187860866706423 no 2738 0.194587451045829 3949 735687
SGTC_2970 9090938 41.86 µM -0.861359778561257 0.187794236336327 no 2739 0.194519960633768 3983 17217104
SGTC_1948 st076329 66.6 µM -0.861781933777195 0.187679521834112 no 2740 0.194403764176994 3794 24208413
SGTC_2277 7947813 106.88 µM -0.863614613978836 0.18718201986484 no 2741 0.193899816704924 4014 1246798
SGTC_490 phenamil 164 µM -0.864413332936152 0.186965453893156 no 2742 0.193680435576921 3893 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2025 5147754 141 µM -0.864705258054233 0.186886339536766 no 2743 0.193600291385695 3899 315777 YLR208W SEC13
SGTC_543 3844-1095 191 µM -0.867731389687834 0.186067451275682 no 2744 0.192770698838312 3934 4230703
SGTC_590 k048-0076 22.4 µM -0.869348694098987 0.185630713070772 no 2745 0.192328218231781 3939 6832814
SGTC_2651 TUB2.036 5 µM -0.870879836556084 0.185217828765221 no 2746 0.191909883684219 3949 15992207 YFL037W TUB2
SGTC_1098 clofazimine 15.1 µM -0.871240091671022 0.185120766153448 no 2747 0.191811536770079 4006 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2121 5257820 149.641 µM -0.871314564648657 0.185100705031596 no 2748 0.191791210061421 3988 791256
SGTC_3312 9133330 71.43 µM -0.871399730639786 0.185077765139751 no 2749 0.191767966410494 3984 17617324
SGTC_328 k915-0120 63.5 µM -0.872055439608133 0.184901205751055 no 2750 0.19158906694266 3925 6624543
SGTC_1906 st060206 94.7 µM -0.872290081076017 0.184838050485537 no 2751 0.191525073700607 3965 5133468
SGTC_2994 9053520 71.4286 µM -0.875291646637567 0.184031342864739 no 2752 0.190707619051184 3996 4647384
SGTC_458 nppb 133 µM -0.875431294524899 0.183993864221421 no 2753 0.190669639162347 3939 4549 A chloride channel blocker.
SGTC_2857 9024691 58.44 µM -0.875576249906344 0.183954966182203 no 2754 0.190630220710806 4018 16478292
SGTC_150 3970-0969 77.2 µM -0.876735451677662 0.183644084524865 no 2755 0.190315173080283 4029 6615640
SGTC_978 1416-0512 87.4 µM -0.876931965780343 0.183591414670375 no 2756 0.190261796237928 3998 6814003
SGTC_1181 1222-0449 220 µM -0.877043395156524 0.183561553469647 no 2757 0.190231534057459 3967 658318
SGTC_1568 digitonin 820 nM -0.87785056109588 0.183345336946372 no 2758 0.190012410856532 3908 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1791 st048313 56.1 µM -0.878569127878063 0.183152987251814 no 2759 0.189817470461708 3922 1204976
SGTC_2257 7960413 200 µM -0.880954450360257 0.182515374621471 no 2760 0.189171237140279 3931 2974689 YIL048W NEO1
SGTC_164 4100-3994 89.624 µM -0.881857290766604 0.182274401484526 no 2761 0.188926992803247 3894 4615967
SGTC_221 trifluoperazine 10.304 µM -0.883294613952382 0.181891182346697 no 2762 0.188538556556294 3918 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_667 1498-1044 59 µM -0.885424229285597 0.181324311442119 no 2763 0.187963934644408 3955 6739982
SGTC_3249 9135183 49.47 µM -0.885659534943377 0.181261744628312 no 2764 0.18790050986711 3964 4902779
SGTC_842 0271-0008 11.1 µM -0.885810005615228 0.181221742179047 no 2765 0.187859958616603 4010 1221709
SGTC_620 0109-0052 432 µM -0.886806194807447 0.180957045960847 no 2766 0.187591625917475 3938 493037
SGTC_117 lucigenin 22.078 µM -0.887533575033212 0.180763927762495 no 2767 0.187395849044589 3998 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2463 5473429 200 µM -0.889578367300264 0.180221731405789 no 2768 0.186846163127323 3951 5399405
SGTC_1996 st072960 66.8 µM -0.891380576767744 0.179744705404184 no 2769 0.186362517111534 3972 1719405
SGTC_2433 5607874 27.82 µM -0.892181771833771 0.179532892397022 no 2770 0.186147755404209 3952 2252428
SGTC_2269 7935389 174.42 µM -0.89321179869239 0.179260813422186 no 2771 0.185871880411038 3907 97605
SGTC_1986 st071812 45 µM -0.893811377015452 0.179102555802358 no 2772 0.185711410476993 3900 11838594
SGTC_2076 5212012 200 µM -0.895303247518125 0.178709160844916 no 2773 0.185312502387444 3876 604802
SGTC_3018 9082602 49.47 µM -0.896066429172409 0.17850812612392 no 2774 0.185108642714559 3948 17332089
SGTC_1234 0326-0494 15.5 µM -0.896426492557764 0.17841332892477 no 2775 0.18501251163302 4045 1547813
SGTC_2804 7954240 19.48 µM -0.897398659286286 0.178157536104645 no 2776 0.184753113857641 4017 828705
SGTC_1693 xanthone 101.9 µM -0.900250957126749 0.177408385234352 no 2777 0.183993356898167 4022 7020 An insecticide.
SGTC_1716 st033144 30.6155 µM -0.900349290894053 0.177382593561894 no 2778 0.183967198800861 3968 674617
SGTC_1982 st072467 71.9 µM -0.901186497748246 0.177163100943948 no 2779 0.183744584375846 3954 3163533
SGTC_1881 5652484 16 µM -0.902599297480452 0.176793092907757 no 2780 0.183369299768064 3940 2255129
SGTC_3055 9094636 49.47 µM -0.902602933556222 0.176792141261021 no 2781 0.183368334527486 3980 25236176
SGTC_2843 9000894 45.46 µM -0.902707203330443 0.176764852781189 no 2782 0.183340656194515 3890 2242070
SGTC_3300 9124615 50.48 µM -0.903565817042604 0.176540245929861 no 2783 0.183112836885793 4029 24824903
SGTC_1190 1486-1332 13 µM -0.904435850384714 0.17631283599606 no 2784 0.182882167779679 3977 4150046
SGTC_672 1441-0018 53.7 µM -0.904468879112359 0.176304206577241 no 2785 0.182873414555202 3966 251141
SGTC_2692 st077426 47.7 µM -0.904910679922434 0.176188802935138 no 2786 0.182756354301481 3999 25238571
SGTC_3132 9126706 49.47 µM -0.905270753314159 0.176094782840423 no 2787 0.182660983283292 4062 850858
SGTC_2971 9092186 9.93 µM -0.905277895326037 0.17609291828459 no 2788 0.182659091925124 4006 25236400
SGTC_1221 2958-7315 257 µM -0.911765151994197 0.174404461587984 no 2789 0.180946179282778 4003 4562705
SGTC_138 0850-0259 40.9225 µM -0.912166101771241 0.1743004438152 no 2790 0.180840642769702 3962 6813004
SGTC_1984 st072354 53.1 µM -0.912213862454963 0.174288055963754 no 2791 0.18082807395189 3865 5762938
SGTC_534 k292-0788 63.4 µM -0.9137535565154 0.17388900000849 no 2792 0.180423177711758 3998 4146317
SGTC_16 erodoxin 22.806 µM -0.914017266098534 0.173820710419932 no 2793 0.180353886600897 4000 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3131 9127911 49.47 µM -0.914655342484751 0.173655546298244 no 2794 0.180186297688764 4044 45595681
SGTC_2055 5235184 200 µM -0.915804205962506 0.173358418331881 no 2795 0.179884798555769 4059 2836034
SGTC_749 1000-0129 128 µM -0.915830610860635 0.173351593099755 no 2796 0.179877872778878 4051 708470
SGTC_1309 pyrazolanthrone 13.4 µM -0.916551554472648 0.17316530713026 no 2797 0.179688840206745 3984 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3153 9100258 49.47 µM -0.91760745897788 0.172892700188933 no 2798 0.17941220572395 3923 25236848
SGTC_833 3852-0053 558 µM -0.918182105478484 0.17274445646005 no 2799 0.179261767711913 4052 3123681
SGTC_374 0880-0231 82.3 µM -0.919515763612472 0.172400719963313 no 2800 0.178912932131375 3914 6833587
SGTC_2375 9072683 200 µM -0.921002978547226 0.172017920716767 no 2801 0.17852443597502 4008 16798029
SGTC_435 c-PAF 6.7 µM -0.921708002851648 0.171836641870583 no 2802 0.178340452531973 4000 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1669 st015249 58.4 µM -0.921845109646265 0.171801402563415 no 2803 0.178304686965443 4069 722793
SGTC_3027 9089541 49.47 µM -0.922017480456798 0.171757106217458 no 2804 0.178259728870085 4022 9943819
SGTC_1049 3226-0134 66 µM -0.92474835000118 0.171056292989422 no 2805 0.177548411452208 4038 5702385
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.924820952563905 0.171037686248751 no 2806 0.17752952493369 3981 688667
SGTC_1907 st060210 83.7 µM -0.925707381435832 0.170810614758139 no 2807 0.177299035398645 4049 688793
SGTC_1175 0741-0056 27.6 µM -0.925752833170886 0.170798976845165 no 2808 0.177287222118368 4103 765927
SGTC_1035 k081-0041 55.2 µM -0.926857587050199 0.170516260778917 no 2809 0.177000240362904 4020 731709
SGTC_1688 st021091 57.6 µM -0.927797949935978 0.170275850015587 no 2810 0.176756193829936 4001 3656366
SGTC_1256 0570-0116 285 µM -0.928999865593402 0.169968887650578 no 2811 0.176444577993206 4028 410638
SGTC_2411 st077133 39.94 µM -0.929651678580122 0.169802566798791 no 2812 0.176275730490003 4113 1403142 YNL221C POP1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.92996364837646 0.169722999493492 no 2813 0.176194953132508 4087 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2351 9026858 72.31 µM -0.930612722415014 0.169557531036033 no 2814 0.176026965526712 3919 1409300
SGTC_2876 9059903 25.97 µM -0.931304874851433 0.169381194673317 no 2815 0.175847940513094 3951 6916095
SGTC_2737 bleomycin 30.5 nM -0.931890991419016 0.169231964628491 no 2816 0.175696431850678 4037 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.932133076007843 0.169170352562271 no 2817 0.175633878146372 3998 6708739 YPR165W RHO1
SGTC_289 k017-0060 526 µM -0.932355425934852 0.169113775783813 no 2818 0.175576436235959 3979 5512909
SGTC_195 4234-0266 16.654 µM -0.932802604970929 0.169000028196259 no 2819 0.175460947996924 4008 2303354
SGTC_452 diindolylmethane 8 µM -0.933003395948381 0.168948969588916 no 2820 0.175409107485561 4010 3071 Inhibits expression of several cancer promoting factors.
SGTC_1482 3346-2049 8.48 µM -0.933011940486206 0.168946797040793 no 2821 0.175406901659565 4000 3826804
SGTC_2902 5787006 60.46 µM -0.934130474349354 0.168662551743132 no 2822 0.175118296963984 3973 591003
SGTC_2944 9067346 25.62 µM -0.934791915170247 0.168494609060681 no 2823 0.174947773463531 3979 6473075
SGTC_56 0957-0365 83.25 µM -0.936893913750055 0.167961616589821 no 2824 0.174406565105629 4008 6752360
SGTC_1705 st027868 56.3335 µM -0.937657472290318 0.167768274150644 no 2825 0.174210232851777 3961 292948
SGTC_305 1682-2595 20.8 µM -0.93787162222411 0.167714074488789 no 2826 0.174155194145489 4038 226033
SGTC_2107 5363541 170.161 µM -0.940615274733488 0.167020675484453 no 2827 0.17345102566501 3997 244052
SGTC_1044 1222-0021 1.78 µM -0.941784876446478 0.166725646710178 no 2828 0.173151394813283 3991 4306703
SGTC_809 3998-0021 90 µM -0.942441943313004 0.166560051035148 no 2829 0.172983210847439 3973 715485
SGTC_3230 9131665 49.47 µM -0.942477249151356 0.166551156173784 no 2830 0.172974176851713 3974 15943720
SGTC_119 0121-0043 24.815 µM -0.943069907153436 0.166401889227781 no 2831 0.172822573442226 4037 1092378
SGTC_3124 9127567 49.47 µM -0.943787888138434 0.166221174155807 no 2832 0.172639025571863 4033 17592030
SGTC_1808 st050063 61.5 µM -0.947424237302783 0.165307856548567 no 2833 0.171711322722533 3988 4011993
SGTC_403 arphamenine a 50 µM -0.948509397315319 0.165035934453093 no 2834 0.171435095540469 3994 5487158 An arginine aminopeptidase inhibitor.
SGTC_2505 galangin 7.89 µM -0.951869882283883 0.164195693943632 no 2835 0.170581487752416 3922 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_836 0330-0104 1.35 µM -0.952208133242417 0.164111273148105 no 2836 0.170495718512674 4028 46494820
SGTC_3073 9114972 49.47 µM -0.954323233897163 0.163584024147036 no 2837 0.169960025425087 4040 41905075
SGTC_37 0566-0070 1.56 µM -0.955377063656656 0.163321738091388 no 2838 0.169693524355529 4013 1626686
SGTC_1409 3909-8004 61.9 µM -0.95635879639615 0.16307764210174 no 2839 0.169445497054366 4045 2119279
SGTC_3076 9116187 49.47 µM -0.956547746853363 0.163030689077543 no 2840 0.169397786869905 4028 27241210
SGTC_1971 st069429 63.5 µM -0.957304045198274 0.162842841589259 no 2841 0.169206907088338 4018 1246522 YGL099W LSG1
SGTC_2382 9035899 200 µM -0.957704677496997 0.162743390592151 no 2842 0.169105848724362 4027 6462679
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.958170639500121 0.162627772171605 no 2843 0.168988359892662 3847 4000243
SGTC_2976 9009005 19.48 µM -0.958480686387328 0.162550870338777 no 2844 0.168910212947754 4061 2993148
SGTC_1562 morin hydrate 59.1 µM -0.959418877612127 0.162318312184165 no 2845 0.168673884417515 4117 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_503 tyrphostin 8 294 µM -0.961252532299783 0.161864412837299 no 2846 0.168212604306682 4043 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3344 9148862 3.898 µM -0.961843921848791 0.161718197948005 no 2847 0.168064005677872 4094 4905352
SGTC_538 2922-0838 53.3 µM -0.962009683811024 0.161677230484068 no 2848 0.16802236978201 4013 777039
SGTC_2595 hexamethylquercetagetin 100 µM -0.965871855077522 0.160724624041057 no 2849 0.167054153660994 4032 386331
SGTC_920 mycophenolic acid 780.421 nM -0.965948319879513 0.16070580103622 no 2850 0.167035020923964 4063 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_763 3453-1109 128 µM -0.96626172040314 0.160628667646565 no 2851 0.166956617781244 4081 1560353
SGTC_2670 beta-carotene 100 µM -0.966935298648743 0.160462970020792 no 2852 0.166788189623905 3977 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_147 4466-0538 29.23 µM -0.970778564359894 0.159519678830058 no 2853 0.165829279567094 4149 6742687 YHR072W ERG7
SGTC_2200 6600604 21.907 µM -0.971392719511039 0.159369277621271 no 2854 0.165676376313903 4030 2904777
SGTC_911 3456-4043 236 µM -0.972147526857227 0.159184559143346 no 2855 0.165488580472009 4092 914281
SGTC_1435 4092-0789 56.7 µM -0.976105317518837 0.158218294370072 no 2856 0.164506138259648 4047 2248285
SGTC_2755 lomerizine 42.69 µM -0.976169656500471 0.158202618353431 no 2857 0.164490198685393 4040 3949 A calcium channel blocker.
SGTC_1436 4092-1007 8.32 µM -0.976346522899243 0.158159530592266 no 2858 0.164446386316328 4052 2881121
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.977097164021735 0.157976746949878 no 2859 0.164260525822832 4065 75037 A free radical scavenger.
SGTC_2204 7233102 200 µM -0.977837237833634 0.157796672313328 no 2860 0.164077415225304 3962 2172480
SGTC_1587 estradiol valerate 56.1 µM -0.981058969839991 0.157014332480154 no 2861 0.163281831143297 4120 13791 A steroid.
SGTC_1578 josamycin 24.2 µM -0.981531581606272 0.156899782148798 no 2862 0.163165334143632 4074 5282165 A P450 substrate.
SGTC_1420 4'-methoxyflavone 42 µM -0.982181720672207 0.156742293108234 no 2863 0.163005165623454 4045 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1895 st058434 18.3 µM -0.984137257421457 0.156269213146526 no 2864 0.162524015100923 4093 5393175
SGTC_2137 5261020 140 µM -0.984334690398805 0.156221502842749 no 2865 0.162475489068151 4026 763655
SGTC_2093 5331342 194.4 µM -0.985475024225659 0.155946125364593 no 2866 0.162195396820365 4152 33839
SGTC_2248 tofa 1.1 µM -0.993215566243825 0.154085335741168 no 2867 0.160302457019867 4037 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3084 9116877 49.47 µM -0.993380568159214 0.154045830620286 no 2868 0.160262263811958 4004 27241325
SGTC_1779 st039427 55 µM -0.993489506797668 0.154019751965165 no 2869 0.160235730801015 4020 1124498
SGTC_1126 isoteolin 1.0172 µM -0.995760386852586 0.153476794550316 no 2870 0.15968329081947 4029 133323
SGTC_111 0083-0039 52.457 µM -0.995974441491472 0.153425680489983 no 2871 0.159631281817532 3966 759313
SGTC_1114 scopoletin 1.73284 µM -0.996544139660164 0.153289697336277 no 2872 0.159492915883481 4122 5280460 A coumarin with genotoxic properties.
SGTC_903 1134-0042 114 µM -0.999679294212696 0.152542786159746 no 2873 0.158732867786779 4115 701009
SGTC_2345 9052315 157.45 µM -1.00047152419251 0.152354430163774 no 2874 0.158541185780256 4135 6469265
SGTC_3105 9121040 49.47 µM -1.00080578810156 0.152275003848208 no 2875 0.158460355355831 3955 41448907
SGTC_247 mechlorethamine 29.705 µM -1.00477428718228 0.151334127317044 no 2876 0.157502773910771 3987 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1744 st037937 38.9 µM -1.00481583230765 0.151324298033421 no 2877 0.157492769409634 4177 1016152
SGTC_1885 st057546 99.9 µM -1.00644395946994 0.150939429001437 no 2878 0.157101028225445 4147 702008
SGTC_3162 9099653 49.47 µM -1.00842617922426 0.150471737068552 no 2879 0.156624955158925 4083 25237511
SGTC_968 1309-0633 340 µM -1.00883432400195 0.15037555792925 no 2880 0.156527048366007 4153 3761976
SGTC_2800 7887935 81.82 µM -1.00904858995146 0.150325082651366 no 2881 0.156475665846192 4113 2961002
SGTC_1490 4089-0339 670 nM -1.01017906038062 0.150058961247309 no 2882 0.156204754789233 4044 742542
SGTC_1116 jasmonic acid 1.58368 µM -1.01439284888927 0.149069771956952 no 2883 0.15519766760876 4167 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_722 3534-0461 190 µM -1.01823476436532 0.148171684454125 no 2884 0.15428320100064 4163 658262
SGTC_101 0490-5701 117.494 µM -1.01965199844053 0.147841307281936 no 2885 0.153946767308026 3897 4661669
SGTC_2179 6298986 200 µM -1.02057114179751 0.1476273059096 no 2886 0.153728833853214 4097 738374
SGTC_1908 st060353 56.5 µM -1.0226087394759 0.147153638336813 no 2887 0.153246437900626 4183 4227716
SGTC_1348 1493-0373 93.8 µM -1.02396808349463 0.146838207352384 no 2888 0.152925175123981 4112 3010129
SGTC_2032 5185112 25.99 µM -1.02604514369765 0.14635710945731 no 2889 0.15243515277219 3983 5718189
SGTC_3061 glucosamine 200 µM -1.02890832852056 0.145695662702957 no 2890 0.151761377168751 4028 91431 and experimental redox chemotherapeutic
SGTC_1301 naphtanilide LB 4.81 µM -1.02893520967867 0.145689462213571 no 2891 0.151755060783677 4183 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1267 0828-0272 9.49 µM -1.03132290981524 0.14513941571505 no 2892 0.15119470918744 4207 745334
SGTC_2831 7999036 19.48 µM -1.03143082030543 0.145114589788124 no 2893 0.151169417028184 4173 2988270
SGTC_2531 methyl deoxycholate 70.07 µM -1.03559504712536 0.144158749103027 no 2894 0.150195551800775 4070 16667744 Haematoxylin.
SGTC_2625 euphol 100 µM -1.03983454615535 0.14319000077574 no 2895 0.149208388070275 4165 6708538 A triterpene alcohol.
SGTC_568 1193-0097 7.48 µM -1.04071329668407 0.142989753023418 no 2896 0.149004315105891 3971 3646150
SGTC_116 0155-0182 31.788 µM -1.04201021763505 0.142694559384948 no 2897 0.148703470896813 4048 771486
SGTC_1552 6-methylflavone 10.6 µM -1.04910418301636 0.141087187339006 no 2898 0.147065085555347 4049 689013
SGTC_1169 aniline yellow 25.8 µM -1.05274832065529 0.140266279576451 no 2899 0.146228178047313 4069 6051 A DNA damaging agent.
SGTC_3182 9108849 49.47 µM -1.05408363890464 0.139966288804016 no 2900 0.14592231305801 4186 17133045
SGTC_692 k241-0027 77.8 µM -1.05413426527381 0.139954923738127 no 2901 0.145910725160958 4210 3600480
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.05487922480634 0.139787760983527 no 2902 0.145740282467774 4188 6708561
SGTC_2105 5350118 200 µM -1.05594171112187 0.139549582764056 no 2903 0.145497423021544 4121 2133313
SGTC_845 0330-0138 4.51 µM -1.05627407893731 0.139475132369318 no 2904 0.145421507454872 4119 9039800
SGTC_3238 9133470 49.47 µM -1.05710508105256 0.139289106120395 no 2905 0.145231816275858 4149 3534688
SGTC_2772 vinpocetine 57.06 µM -1.05719384651937 0.139269245268643 no 2906 0.145211563807921 4187 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3179 9107801 49.47 µM -1.05870478469893 0.138931475571533 no 2907 0.144867124070057 4142 4818259
SGTC_1508 1080-0625 72.9 µM -1.05911784533281 0.13883923317777 no 2908 0.144773056883592 4023 767111
SGTC_3195 9113082 49.47 µM -1.05915442832164 0.138831065679939 no 2909 0.144764727744214 4137 17018038
SGTC_1914 st062367 72.6 µM -1.05992915399674 0.138658177688078 no 2910 0.144588415583338 4143 978205
SGTC_945 3381-0768 11.3 µM -1.06046838690944 0.138537928929705 no 2911 0.144465782314261 4189 1126236 YIL048W NEO1
SGTC_2628 lathosterol 100 µM -1.06085316023051 0.138452168061618 no 2912 0.144378319369632 4215 6710616
SGTC_1509 1326-1131 80 µM -1.06087480096104 0.138447345704791 no 2913 0.144373401268604 4124 768313
SGTC_3048 9093155 49.47 µM -1.06155103344453 0.138296713716517 no 2914 0.14421977666789 4127 25236002
SGTC_1188 1403-0014 4.57 µM -1.06382462911532 0.137791085700403 no 2915 0.143704075928667 4139 9614867
SGTC_2311 7694451 200 µM -1.06452784963324 0.137634951262437 no 2916 0.14354482255815 4143 2163142
SGTC_2744 captopril 92.04 µM -1.06548236989485 0.137423214573876 no 2917 0.143328849774014 4199 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3064 1327-0027 10 µM -1.06590651522493 0.137329199841501 no 2918 0.143232951757243 4074 16000455 YPR107C YTH1
SGTC_453 enantio-paf c16 10 µM -1.06604676866369 0.137298121367005 no 2919 0.143201250402093 3956 13871343 A lipid and platelet activating factor
SGTC_397 arbidol 50 µM -1.0662930121735 0.137243568388575 no 2920 0.143145603674472 4204 131410 A RNA synthesis inhibitor.
SGTC_3007 9078383 71.4286 µM -1.0684391310078 0.136768742356641 no 2921 0.14266123680005 4148 6496995
SGTC_2886 9058944 51.95 µM -1.06998502202136 0.136427412564389 no 2922 0.142313025325856 4019 4949929
SGTC_1776 st049249 45.9 µM -1.0742174201257 0.135495890569773 no 2923 0.141362623278007 4182 1822314
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.07508874379552 0.13530466043604 no 2924 0.141167499256646 4170 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1656 st012921 11 µM -1.07528854523572 0.135260835935033 no 2925 0.141122781519333 4086 6732821
SGTC_2034 5197015 53.07 µM -1.07770881630134 0.13473074585872 no 2926 0.140581861394609 4176 780676
SGTC_1700 st030840 7.9285 µM -1.07920177379695 0.134404468698992 no 2927 0.140248894557004 4221 5499307
SGTC_2761 levamisole 97.89 µM -1.079660912461 0.134304235789477 no 2928 0.140146602940371 4176 26879 An alkaline phosphatase inhibitor.
SGTC_3342 9147791 14.508 µM -1.08099229268581 0.134013877259673 no 2929 0.139850271031123 4089 1838168
SGTC_2474 5321570 43.32 µM -1.08107857658258 0.133995074639997 no 2930 0.139831081101434 4173 2841384
SGTC_1088 bifonazole 369 nM -1.0813909606254 0.133927016400339 no 2931 0.139761620445375 4127 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1479 0549-0158 134 µM -1.08224975731956 0.133740035202846 no 2932 0.13957078222715 4225 5440202
SGTC_654 1124-0271 80.9 µM -1.08262382896188 0.133658646726543 no 2933 0.139487713018601 4154 5403748
SGTC_566 0958-0068 16.5 µM -1.08277261364267 0.13362628443196 no 2934 0.139454682104523 4097 6815365
SGTC_1454 4239-0054 42.6 µM -1.08567622811458 0.132995794997721 no 2935 0.138811130742463 4277 1340767
SGTC_1242 0402-0103 60.1 µM -1.08595203055211 0.13293601406619 no 2936 0.138750107787212 4103 432868
SGTC_2207 7258803 200 µM -1.08637965179822 0.132843362576681 no 2937 0.138655530134802 4165 3666799
SGTC_3114 9122766 49.47 µM -1.08816073790165 0.132457938031001 no 2938 0.138262077032334 4184 17176985
SGTC_2348 9022543 33.42 µM -1.08823140368166 0.132442661964135 no 2939 0.13824648223177 4220 3162678 YDL140C RPO21
SGTC_3334 9142812 21.919 µM -1.0884802048233 0.132388887420089 no 2940 0.138191585367027 4178 45283678
SGTC_1898 st060199 18.6 µM -1.08925616432919 0.132221272348681 no 2941 0.138020468826922 4168 688866
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.09012987722321 0.132032716731356 no 2942 0.137827968498824 4245 1273210
SGTC_2689 tacrolimus 100 µM -1.0965868315779 0.130644993222078 no 2943 0.136411023272586 4213 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2014 4013930 200 µM -1.09698644805747 0.130559440567367 no 2944 0.136323658137799 4166 64556
SGTC_2932 9016711 44.54 µM -1.0981096055456 0.130319194741059 no 2945 0.136078315728047 4205 7117328
SGTC_1248 0469-0687 58.6 µM -1.10122470530847 0.129654469184957 no 2946 0.135399435931098 4172 4017482
SGTC_2920 7982904 15.77 µM -1.10183187185197 0.129525180967337 no 2947 0.135267385710443 4206 6456808
SGTC_1006 4099-6547 255 µM -1.10185767054159 0.129519689450857 no 2948 0.13526177681271 4217 3146833
SGTC_2829 7992743 58.44 µM -1.10265385852056 0.129350291949324 no 2949 0.135088755825639 4197 16462845
SGTC_2847 9005661 71.43 µM -1.10323702504584 0.12922631449561 no 2950 0.134962123232443 4200 2991449
SGTC_1739 st037196 92.5 µM -1.10542259893555 0.128762408472329 no 2951 0.134488257950275 4267 612214
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.10544721235367 0.128757190659456 no 2952 0.134482927903319 4183 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_423 5-fluorouracil 457 µM -1.10850245998659 0.128110645872859 no 2953 0.133822438660728 4135 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1804 st050076 49.1 µM -1.11105403515513 0.127572417923359 no 2954 0.133272545607397 4229 3895976
SGTC_2065 5221596 34.26 µM -1.11198045453588 0.127377389087737 no 2955 0.133073277097837 4191 788581
SGTC_2608 thymoquinone 42.66 µM -1.11198780064806 0.127375843421066 no 2956 0.133071697803168 4201 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_333 3486-0131 40.1 µM -1.11457640102587 0.126831998180818 no 2957 0.132515993885865 4238 6744690
SGTC_38 0929-0051 58.268 µM -1.11477574738602 0.126790184169048 no 2958 0.132473265908767 4197 1379719
SGTC_1304 1165-0502 251 µM -1.11648944052209 0.126431123363765 no 2959 0.132106343830864 4194 767425
SGTC_2647 atorvastatin 60.16 µM -1.11943921516682 0.125814733590029 no 2960 0.131476404513559 4184 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1944 st076371 56.9 µM -1.12163429847975 0.125357407700817 no 2961 0.131008981112651 4177 24208455
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.12180067963883 0.125322791054234 no 2962 0.130973598600192 4200 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_934 2950-0684 338 µM -1.12444863868045 0.124772764636634 no 2963 0.1304113739562 4253 1121253
SGTC_2713 st079149 53.4 µM -1.12455321875451 0.124751076247396 no 2964 0.130389203439391 4217 3103253
SGTC_2810 7959871 45.46 µM -1.12561998838009 0.124529994208419 no 2965 0.130163201887488 4184 2974535
SGTC_2395 5646831 180.19 µM -1.12606822501601 0.12443718144758 no 2966 0.130068321189583 4240 6808628
SGTC_2724 maprotiline 69.64 µM -1.12733606031262 0.124174922901561 no 2967 0.129800210783146 4139 4011 A tricyclic antidepressant.
SGTC_3354 9151612 71.43 µM -1.12836448737459 0.123962471461621 no 2968 0.129583009575445 4232 27261949
SGTC_926 2268-1401 59.4 µM -1.12849027596848 0.123936503649038 no 2969 0.129556460631769 4193 2931578
SGTC_933 2914-0560 114 µM -1.1294547996708 0.123737513773509 no 2970 0.129353013456819 4244 463887
SGTC_2246 7293507 91.5585 µM -1.13131513143627 0.123354342704142 no 2971 0.128961238909084 4269 887656
SGTC_1843 st055809 45.5 µM -1.13258832638658 0.123092583369535 no 2972 0.12869358658054 4282 16413835
SGTC_1935 st074532 41.6 µM -1.13339229534648 0.122927494065238 no 2973 0.128524774083583 4209 2829742
SGTC_1208 2323-2347 50.3 µM -1.13652596327385 0.122285499720402 no 2974 0.127868252919283 4223 5412760
SGTC_3060 1327-0027 12.5 µM -1.14025299155954 0.121525012486736 no 2975 0.127090458049591 4141 16000455 YPR107C YTH1
SGTC_1176 0848-0131 83.3 µM -1.14120193233959 0.121331916510373 no 2976 0.126892950205384 4276 6769040
SGTC_894 0960-0238 55.9 µM -1.14215487273275 0.121138223881263 no 2977 0.126694825026791 4234 6741907 YDL195W SEC31
SGTC_608 k048-0125 159 µM -1.14286612528728 0.120993798027593 no 2978 0.12654708946513 4273 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_710 3448-4187 58 µM -1.14497471106058 0.120566343957424 no 2979 0.126109816639808 4207 3946412
SGTC_1766 st045414 44.774 µM -1.1490116129515 0.119750949326603 no 2980 0.125275596067708 4250 253960
SGTC_1021 4476-0760 85.3 µM -1.14928455222932 0.119695960303752 no 2981 0.12521933289727 4241 746768
SGTC_3277 9138724 49.47 µM -1.14995141692423 0.119561682117616 no 2982 0.125081940933991 4202 15943418
SGTC_1320 1313-0481 95.3 µM -1.15009168163962 0.119533452300569 no 2983 0.125053056057694 4223 6813365 YLR208W SEC13
SGTC_253 dyclonine 31.25 µM -1.15023874386826 0.119503859458888 no 2984 0.12502277636499 4338 3180 An oral anasthetic.
SGTC_183 3914-0051 30.55 µM -1.15090948916818 0.119368953166284 no 2985 0.124884736771115 4276 1596232
SGTC_2820 7989630 71.43 µM -1.15620747611867 0.118307150711861 no 2986 0.123798151288292 4280 2984098
SGTC_3117 9124945 49.47 µM -1.15653025324917 0.118242677432882 no 2987 0.123732166180355 4148 17592065
SGTC_1900 st060200 72.8 µM -1.15668313556254 0.118212148550699 no 2988 0.123700921148711 4236 688945
SGTC_2285 7945142 200 µM -1.16024574352655 0.117502313473639 no 2989 0.122974383830624 4296 2970608
SGTC_3090 9117696 49.47 µM -1.16097860969035 0.117356667916675 no 2990 0.122825299181339 4212 7923821
SGTC_1004 4084-0029 199 µM -1.1611584459623 0.117320947846391 no 2991 0.122788735031757 4265 716894 YLR208W SEC13
SGTC_2696 st077691 74.316 µM -1.1674617486065 0.116073812915996 no 2992 0.12151197354999 4314 757133
SGTC_3068 9116768 49.47 µM -1.17234385873335 0.11511435487886 no 2993 0.120529514801743 4239 41904888
SGTC_1621 st003705 32.4 µM -1.1746890719896 0.114655471666958 no 2994 0.120059566485338 4258 24207032
SGTC_2324 6149169 200 µM -1.17842087814934 0.113927962905887 no 2995 0.119314429178654 4167 2888231
SGTC_287 k060-0039 29.6 µM -1.17905353637904 0.113804954146585 no 2996 0.119188429277023 4303 5861974
SGTC_1848 st056003 16.4 µM -1.1799326622924 0.113634181472541 no 2997 0.119013498973804 4278 146492
SGTC_324 1315-0088 19.6 µM -1.18476479847602 0.112698786948408 no 2998 0.118055227113486 4233 6787421
SGTC_2331 7980721 200 µM -1.18517228085518 0.112620159507702 no 2999 0.117974668588397 4227 2981221
SGTC_604 1000-0114 314 µM -1.18825406361787 0.112026769853211 no 3000 0.117366664820372 4287 1572745
SGTC_2292 7671323 168.05 µM -1.18977190620378 0.111735336003491 no 3001 0.117068027213366 4324 937504
SGTC_687 k029-0044 34.9 µM -1.19052797576718 0.111590369147939 no 3002 0.116919470555085 4344 5829338
SGTC_832 4083-0019 164 µM -1.19204828934489 0.111299275558482 no 3003 0.116621155639131 4359 1990758
SGTC_2640 pentamidine 10.38 µM -1.1934429806169 0.111032713234197 no 3004 0.116347965294438 4259 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2346 9031566 143.75 µM -1.19358848861129 0.111004929177413 no 3005 0.116319489551719 4245 4771086
SGTC_974 1326-0144 138 µM -1.19481530760369 0.110770871918733 no 3006 0.116079599111466 4307 5411856
SGTC_1371 2421-0008 32.7 µM -1.19503754578339 0.110728510321005 no 3007 0.116036180569967 4266 2827552
SGTC_1506 4226-2149 212 µM -1.202926291373 0.109232321563984 no 3008 0.114502422596531 4298 991114
SGTC_2237 6667747 47.222 µM -1.20415879036972 0.108999882586854 no 3009 0.114264105228801 4301 729940 YDL015C TSC13
SGTC_329 k048-0121 21.3 µM -1.20433734416972 0.1089662383424 no 3010 0.114229609182414 4307 6832902
SGTC_481 bay k-8644 50 µM -1.20802860187711 0.108272379665007 no 3011 0.113518130422951 4258 2303 A calcium channel antagonist.
SGTC_1966 st070145 16.1 µM -1.21082461866682 0.107748923177429 no 3012 0.112981313901451 4278 3748532
SGTC_1877 wortmannin 25 µM -1.21157403677317 0.107608931125209 no 3013 0.112837739034626 4305 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3347 9188721 44.724 µM -1.21212780186158 0.107505571485049 no 3014 0.112731731442418 4310 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2764 methyldopa 94.69 µM -1.21357629106979 0.107235550962802 no 3015 0.112454782592578 4294 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2819 7996655 46.38 µM -1.21553838208743 0.106870567530455 no 3016 0.112080409523782 4252 6456960
SGTC_2398 5228213 48.84 µM -1.22032317015074 0.105984272597913 no 3017 0.111171194831711 4289 80771 YMR134W ERG29
SGTC_1398 3558-0053 112 µM -1.2209972826956 0.105859833624284 no 3018 0.111043524314707 4242 4532369
SGTC_739 1486-1183 203 µM -1.22207822756968 0.105660515220671 no 3019 0.110839022864244 4307 4346692
SGTC_1876 myriocin 605 nM -1.22682080746533 0.104789224595861 no 3020 0.109944974231593 4304 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_192 3455-0609 60.9 µM -1.22847897958957 0.104485821778509 no 3021 0.109633607773907 4373 3769639
SGTC_2286 7945697 125 µM -1.22849390771712 0.104483093209208 no 3022 0.109630807494545 4319 1245733
SGTC_1665 st014639 11.4 µM -1.23173894686774 0.103891188351574 no 3023 0.109023308103036 4375 981133 YIL048W NEO1
SGTC_683 panaxydol 45 µM -1.23757706099859 0.102832429404438 no 3024 0.107936462194033 4326 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2642 cholecalciferol 100 µM -1.23921240332382 0.102537265863994 no 3025 0.107633424195732 4294 9821465 A vitamin D precursor, similar to steriods.
SGTC_2520 obtusaquinone 4.71 µM -1.23995347533926 0.102403712488879 no 3026 0.107496301467033 4360 5967872
SGTC_522 1273-0010 11.6 µM -1.24075028451182 0.102260255530004 no 3027 0.107349006035839 4372 5705015
SGTC_3287 9117173 37.0625 µM -1.24200033990618 0.102035491078795 no 3028 0.107118218318848 4318 2789709
SGTC_861 0443-0273 110 µM -1.24202585449825 0.102030907209879 no 3029 0.107113511493173 4317 6149169
SGTC_2863 9028737 58.44 µM -1.24240246164749 0.101963264618237 no 3030 0.107044053923181 4299 6460917
SGTC_1498 4478-3555 97.6 µM -1.24466787268915 0.101557061542866 no 3031 0.106626930054684 4298 3437919
SGTC_2313 7726885 200 µM -1.2465229848248 0.101225306415553 no 3032 0.106286228126713 4335 726423
SGTC_3340 9146634 11.102 µM -1.24751863127982 0.101047578035129 no 3033 0.10610369653349 4319 4907387
SGTC_232 clozapine 119 µM -1.2512167857171 0.100389428550898 no 3034 0.10542769785282 4329 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_651 3253-0966 34.4 µM -1.25228464390782 0.100199968355009 no 3035 0.105233081188812 4338 781462
SGTC_2077 5212015 200 µM -1.25833494183507 0.0991314472167759 no 3036 0.104135324721352 4231 780900
SGTC_2837 9008476 45.46 µM -1.25843782088401 0.0991133504574746 no 3037 0.104116730565298 4313 2992805
SGTC_1418 3966-3099 2.4 µM -1.26171695116638 0.0985378059795456 no 3038 0.103525327536291 4336 740335
SGTC_2262 9014885 67.46 µM -1.26303484930428 0.0983071825142773 no 3039 0.103288327930044 4341 6457424
SGTC_2827 7993847 71.43 µM -1.26579441201741 0.0978255582815447 no 3040 0.102793348113763 4394 2985692
SGTC_2412 st077135 33.4 µM -1.26622848442586 0.0977499576759258 no 3041 0.102715646164977 4390 13258915
SGTC_2532 xanthone 78.9 µM -1.26815595531346 0.0974147753378056 no 3042 0.102371131209675 4355 7020 An insecticide.
SGTC_2363 9053361 176 µM -1.27181640992383 0.0967805537660334 no 3043 0.1017191785274 4394 6469797 YMR079W SEC14
SGTC_3139 9095020 49.47 µM -1.27464123395609 0.0962931929274964 no 3044 0.101218127869788 4168 25236292
SGTC_3150 9097574 49.47 µM -1.27591891841053 0.0960733501673524 no 3045 0.100992091351461 4384 17217476
SGTC_837 0091-0265 12.5 µM -1.27909395289774 0.0955286412428889 no 3046 0.100431986411433 4338 759367
SGTC_2087 5276107 200 µM -1.28016087065692 0.095346112001049 no 3047 0.10024428217526 4306 144405
SGTC_2219 9098279 200 µM -1.28032512386875 0.0953180342370443 no 3048 0.1002154076533 4290 902349
SGTC_1275 0867-0008 21.1 µM -1.28066626960549 0.0952597375725061 no 3049 0.100155456110156 4324 3422836
SGTC_1494 4358-1428 177 µM -1.28080021618555 0.0952368552997121 no 3050 0.100131924050978 4371 1564571
SGTC_2045 5106652 78.05 µM -1.28165213123974 0.0950914162377785 no 3051 0.0999823520255448 4317 673349
SGTC_3069 9117009 49.47 µM -1.28441045138315 0.094621637751695 no 3052 0.0994991889853079 4341 41904981
SGTC_1201 1889-3372 45.9 µM -1.28667987356339 0.0942364096372527 no 3053 0.0991029454713928 4236 5392199
SGTC_2760 etidronate 98.04 µM -1.28905642206705 0.0938342384762448 no 3054 0.0986892360096395 4323 3305 A chelator and antioxidant.
SGTC_2617 dihydrotanshinone i 20.83 µM -1.29051910414088 0.0935873468835042 no 3055 0.0984352415751532 4315 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1362 1611-0397 101 µM -1.29059924973408 0.0935738326838595 no 3056 0.0984213381549443 4323 27816
SGTC_4 0960-0234 25.671 µM -1.29070151045027 0.0935565915109742 no 3057 0.0984036003566678 4359 6821112
SGTC_1390 3413-2614 145 µM -1.29419691839487 0.0929686749139587 no 3058 0.0977987054757614 4370 3421432
SGTC_702 1488-0190 94 µM -1.29464797355861 0.0928930082560892 no 3059 0.0977208474968015 4392 949357
SGTC_1205 4161-2785 76 µM -1.30109631598299 0.0918162417405886 no 3060 0.0966127443132961 4385 3498106
SGTC_1637 st007924 17.4 µM -1.30236784138052 0.0916050136876234 no 3061 0.0963953352049823 4279 683336
SGTC_24 0417-1663 219 µM -1.30614049534684 0.0909804130937904 no 3062 0.0957523919838152 4394 4329390
SGTC_1579 chlormadinone acetate 49.4 µM -1.30820720836826 0.0906395902621197 no 3063 0.0954015189028914 4411 45114258 A steroidal progestin.
SGTC_2199 6590217 200 µM -1.30974990779016 0.0903858011862371 no 3064 0.0951402270123302 4283 703109
SGTC_817 1391-0715 46 µM -1.3106815338553 0.0902327953914979 no 3065 0.0949826900059712 4353 1353946
SGTC_2221 6807166 181.081 µM -1.31350908697306 0.0897695897456482 no 3066 0.0945057304736881 4340 674925
SGTC_399 oxolinic acid 75 µM -1.31587407852962 0.0893835197019089 no 3067 0.0941081551584558 4351 4628 A DNA gyrase inhibitor.
SGTC_2773 thioridazine 9.09 µM -1.31634647723842 0.0893065517863184 no 3068 0.0940288889676038 4356 5452 An antipsychotic.
SGTC_2430 5571206 200 µM -1.31671547783874 0.0892464648318262 no 3069 0.0939670067517164 4368 1731771
SGTC_937 3122-0005 46.7 µM -1.3173889767391 0.0891368718473618 no 3070 0.0938541369949374 4389 759535
SGTC_1171 0368-0077 21.4 µM -1.32121736740829 0.0885158111009258 no 3071 0.0932144485249591 4346 3239779
SGTC_2491 paeonol 100 µM -1.32150760508141 0.0884688590823966 no 3072 0.0931660842118558 4329 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1013 4112-3890 241 µM -1.32246692065679 0.0883138017326063 no 3073 0.0930063587589918 4329 705171
SGTC_878 0828-0289 13.7 µM -1.324155674375 0.0880413351143097 no 3074 0.0927256742620052 4329 745350 YLR208W SEC13
SGTC_961 1252-1571 372 µM -1.32482231946585 0.0879339500917405 no 3075 0.0926150450988236 4396 6813498
SGTC_325 2810-4341 181 µM -1.32750083033191 0.0875034727474907 no 3076 0.0921715327238637 4380 774970
SGTC_3336 9143619 71.43 µM -1.32882146887637 0.0872918058629293 no 3077 0.0919534387272312 4398 45595730
SGTC_377 3970-0964 33.1 µM -1.32908174258732 0.0872501353192603 no 3078 0.0919105015052293 4366 16481235
SGTC_348 k064-0012 10.7 µM -1.3319618550869 0.0867900123892053 no 3079 0.0914363616937369 4317 5066323
SGTC_3214 9129694 49.47 µM -1.33479974985518 0.0863384099743996 no 3080 0.0909709476978947 4417 17158655
SGTC_1773 st048542 73.5835 µM -1.3390671546491 0.0856626367917968 no 3081 0.0902744059846464 4367 3237138
SGTC_2780 5215298 71.43 µM -1.34351293381792 0.0849628367419497 no 3082 0.0895529704269308 4413 2834131
SGTC_2915 7971052 15.16 µM -1.34599817572171 0.0845735124173286 no 3083 0.0891515524571323 4316 5741558
SGTC_1610 st001799 48.1 µM -1.34882658645708 0.084132059020842 no 3084 0.0886963365026616 4356 621897
SGTC_2139 5578692 56.4705 µM -1.34989743295924 0.0839653753631911 no 3085 0.0885244426195802 4379 650991 YMR113W FOL3
SGTC_193 1273-0060 1.558 µM -1.35018914239632 0.0839200120508594 no 3086 0.0884776600233306 4228 2847393 YHR072W ERG7
SGTC_1849 st056239 19.2 µM -1.35123376904781 0.0837577146315376 no 3087 0.0883102802009825 4394 5393181
SGTC_2738 aclarubicin 5.55 µM -1.3515892382657 0.0837025412967374 no 3088 0.0882533774548545 4426 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2526 patulin 37.61 µM -1.35345366852462 0.0834136051367003 no 3089 0.087955370972191 4431 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_606 k015-0008 38.6 µM -1.3542702852673 0.0832872880147278 no 3090 0.0878250812966036 4467 1970475
SGTC_652 0437-0092 114 µM -1.35682808743391 0.0828925688978935 no 3091 0.0874179203567685 4361 3091274
SGTC_992 3909-8734 162 µM -1.35886030593906 0.0825799622179674 no 3092 0.08709542958675 4415 4288319
SGTC_3271 9137798 49.47 µM -1.35917620482613 0.0825314487634961 no 3093 0.0870453797949535 4395 6498326
SGTC_1400 3771-8998 51.5 µM -1.36078485064962 0.0822847373801237 no 3094 0.0867908453829239 4345 670767
SGTC_3086 9117350 49.47 µM -1.36162264464703 0.0821564685205259 no 3095 0.0866585025315448 4371 2679265
SGTC_1837 st055472 66.5 µM -1.3692789012483 0.0809912412696138 no 3096 0.085456055297965 4466 676091
SGTC_466 geldanamycin 89.2 µM -1.37149931106889 0.0806556553219546 no 3097 0.085109679066763 4428 5288382 HSP90 inhibitor.
SGTC_1061 3448-9325 110 µM -1.37287138479916 0.0804488098923971 no 3098 0.0848961669108074 4372 723482
SGTC_838 0109-0203 71.4 µM -1.3734875263191 0.080356054669033 no 3099 0.0848004181917926 4441 759422
SGTC_2955 9076254 12.21 µM -1.38320215488832 0.0789042562036608 no 3100 0.0833014445955455 4343 16459619
SGTC_2341 7987486 176.74 µM -1.38474450548439 0.0786755996627494 no 3101 0.0830653025856318 4443 1258686
SGTC_1322 1348-1070 12 µM -1.38538704105529 0.0785804907976011 no 3102 0.0829670756901158 4421 6758089
SGTC_2114 5491910 81.25 µM -1.38615398333268 0.0784670812263348 no 3103 0.0828499446775297 4457 2849228
SGTC_2078 5212016 200 µM -1.38756319966507 0.0782590206006104 no 3104 0.0826350469555922 4329 1899708
SGTC_959 1222-0044 107 µM -1.39077001910957 0.0777871165144298 no 3105 0.0821475886164824 4416 6083612
SGTC_1692 fluoroquinolonic acid 71 µM -1.39561962716221 0.0770775727750083 no 3106 0.0814145344119151 4450 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_12 0849-0099 9.267 µM -1.39905087312301 0.0765785275488559 no 3107 0.0808988640326406 4371 6071388
SGTC_2252 omeprazole 400 µM -1.39907184479449 0.0765754849739199 no 3108 0.0808957198697793 4463 4594 A proton pump inhibitor.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.40343230558969 0.0759448632717123 no 3109 0.0802439825749217 4452 390807
SGTC_2741 miltefosine 3.04 µM -1.403930804185 0.0758730216703043 no 3110 0.0801697278586384 4487 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2161 5662504 8.5105 µM -1.40437970296559 0.0758083724906348 no 3111 0.0801029058219811 4393 2859334
SGTC_1259 0671-0132 43 µM -1.4046231481715 0.0757733297256685 no 3112 0.0800666847433457 4375 X1259
SGTC_2194 5927483 104.545 µM -1.4090275931171 0.0751414600300783 no 3113 0.0794135045935985 4478 760979
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.4114315586385 0.0747982818924653 no 3114 0.079058701514107 4380 6708630 An antioxidant.
SGTC_1735 st034310 56.75 µM -1.41175954843435 0.0747515525603483 no 3115 0.0790103864709083 4471 871153
SGTC_3262 9137218 49.47 µM -1.41374006174786 0.0744698582798732 no 3116 0.0787191190075831 4412 17650664
SGTC_2325 6158266 200 µM -1.41873461137182 0.0737630679019746 no 3117 0.0779882012570455 4431 3623240
SGTC_3100 9120536 49.47 µM -1.41956152483047 0.073646545808915 no 3118 0.0778676866554431 4334 16421196
SGTC_598 3937-0236 20.2 µM -1.41956492870551 0.0736460664528039 no 3119 0.0778671908659793 4517 1379313
SGTC_2298 7976326 193.81 µM -1.42209597744515 0.0732902873850647 no 3120 0.0774991951973892 4391 2235818
SGTC_21 0849-0113 22.993 µM -1.42219154437943 0.073276879740627 no 3121 0.07748532639461 4409 1560156
SGTC_1676 st018489 23.4 µM -1.42286758399483 0.0731820877662847 no 3122 0.0773872724303549 4439 3696235
SGTC_2066 5222451 176 µM -1.42474329891476 0.0729195726945012 no 3123 0.0771157089824025 4400 2281147
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.4276928785689 0.0725082240533106 no 3124 0.0766901384182802 4445 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_563 tetrahydrosecaminediol 614 µM -1.4280066586909 0.0724645690664991 no 3125 0.0766449709778695 4490 334274 A psychoactive constituent of the cannabis plant.
SGTC_1684 st024538 14.6195 µM -1.42851738773781 0.0723935564178631 no 3126 0.0765714967661777 4422 6732859
SGTC_1496 4469-0713 57.4 µM -1.43116830849252 0.0720258241355334 no 3127 0.0761909919629433 4432 746691
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.43401769820651 0.0716321592551816 no 3128 0.0757836061902176 4499 5282309
SGTC_1825 st052143 62.6 µM -1.43762391775807 0.0711363017479671 no 3129 0.0752703954129297 4489 674173
SGTC_935 2996-0153 430 µM -1.44104991689141 0.0706676701048881 no 3130 0.0747852905712202 4466 23738523
SGTC_658 3253-0951 102 µM -1.44193295209674 0.070547267909152 no 3131 0.0746606445619592 4478 1184878
SGTC_2638 epoxomicin 18 µM -1.44444050922574 0.0702062211322379 no 3132 0.074307551348266 4433 9915668 A protesome inhibitor.
SGTC_619 1652-1634 108 µM -1.4464157781315 0.0699384635833151 no 3133 0.074030309504493 4447 5400454
SGTC_2919 7978188 46.38 µM -1.44725666568563 0.0698247158264494 no 3134 0.0739125255657396 4471 2980291
SGTC_118 0083-0097 135.343 µM -1.45126601901639 0.0692843232623732 no 3135 0.0733528998319754 4448 5207356
SGTC_2176 5809774 33.9695 µM -1.45527291652784 0.0687474863271996 no 3136 0.0727968607013293 4383 2870539
SGTC_788 1182-0090 188 µM -1.45580277453388 0.0686767376695317 no 3137 0.0727235742811957 4471 5715185
SGTC_1729 st035615 45.989 µM -1.45609752955026 0.0686374051704365 no 3138 0.0726828301990149 4475 17385451
SGTC_882 0843-0131 351 µM -1.46127085452658 0.0679498947952617 no 3139 0.0719705624960805 4473 5425421
SGTC_2172 5754775 163.918 µM -1.46294142289089 0.0677290236946725 no 3140 0.0717417040657796 4467 2263357
SGTC_66 0109-0187 42.4 µM -1.46654746210299 0.0672541488775994 no 3141 0.071249600485013 4335 759417
SGTC_1867 st057372 64 µM -1.46700535881578 0.0671940336683569 no 3142 0.071187298792132 4441 688837
SGTC_102 gallobenzophenone 83.616 µM -1.47148619577459 0.0666079551789994 no 3143 0.0705798389994151 4458 70837
SGTC_780 0109-0199 192 µM -1.4729618492098 0.0664158131446196 no 3144 0.0703806615836365 4512 610414
SGTC_1382 3002-2117 298 µM -1.47943685355831 0.065577784064127 no 3145 0.0695117982691517 4543 1497314
SGTC_670 4204-0025 119 µM -1.48189919755778 0.0652612550509877 no 3146 0.0691835593065493 4493 719039
SGTC_2104 5389443 200 µM -1.48283484815891 0.0651412904324908 no 3147 0.0690591474317123 4504 2244536
SGTC_1001 4048-4355 44.4 µM -1.48308705113429 0.0651089834779555 no 3148 0.0690256419485458 4478 21824233
SGTC_2946 9065502 71.43 µM -1.48496175844507 0.0648692249054583 no 3149 0.0687769772862178 4345 16489101
SGTC_3118 9124250 49.47 µM -1.48615722668832 0.0647166933154722 no 3150 0.0686187691856451 4448 1504786
SGTC_2543 pimpinellin 60.67 µM -1.48748243227194 0.0645479340100137 no 3151 0.0684437198527339 4346 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_275 trichlorophene 5.69 µM -1.49002204939127 0.0642254800650146 no 3152 0.0681092192154933 4525 62616
SGTC_2769 toremifene 3.73 µM -1.49141905418428 0.0640486376127977 no 3153 0.0679257542960343 4492 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3183 9108214 49.47 µM -1.49425429095489 0.0636908979710882 no 3154 0.0675545836413757 4484 4974831
SGTC_2050 5263056 171 µM -1.49479355450435 0.0636230319913184 no 3155 0.0674841645074204 4480 763468 YGL055W OLE1
SGTC_3315 9136395 68.55 µM -1.49508196195808 0.0635867591944341 no 3156 0.0674465264286644 4475 16876844
SGTC_3152 9099253 49.47 µM -1.51103241814583 0.0616056245290719 no 3157 0.0653900957774102 4364 25236131
SGTC_2000 st075254 36.4 µM -1.51304026599699 0.0613596922588271 no 3158 0.0651347155711668 4384 17234175
SGTC_1649 st011737 51.3 µM -1.51321530790438 0.0613382885598021 no 3159 0.0651124885429701 4519 1761035
SGTC_902 1120-0002 2.07 µM -1.51329089358331 0.0613290479300414 no 3160 0.0651028924040025 4484 3280475
SGTC_3119 9125183 49.47 µM -1.5134968286118 0.0613038771267131 no 3161 0.0650767530576285 4369 22695334
SGTC_2360 9040895 200 µM -1.52010919942837 0.0604999498047788 no 3162 0.0642417664512487 4527 4914414
SGTC_2619 obliquin 87.91 µM -1.52284179856567 0.0601701408548583 no 3163 0.063899144886237 4485 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2747 doxorubicin 7.63 µM -1.52561815936421 0.0598364933478528 no 3164 0.063552493487204 4565 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2384 9036245 200 µM -1.52589596290586 0.0598031883912185 no 3165 0.0635178881354379 4456 6462766
SGTC_1213 1315-0166 115 µM -1.52685252252105 0.0596886206728786 no 3166 0.0633988438623816 4506 768401
SGTC_2218 6965428 192.983 µM -1.53176431859017 0.0591030384759343 no 3167 0.062790302038944 4426 675684
SGTC_167 3672-0051 66.205 µM -1.53387886443916 0.0588523349063039 no 3168 0.0625297282598126 4426 3237971
SGTC_1794 st048918 76.9 µM -1.54128686325624 0.0579806100226944 no 3169 0.0616234923383407 4492 672303
SGTC_644 1498-1197 63.3 µM -1.54389851368191 0.0576757189259596 no 3170 0.0613064601196111 4561 6741615
SGTC_480 am 92016 50 µM -1.54812024331497 0.0571855307504893 no 3171 0.0607966745484205 4533 2129 K+ channel blocker.
SGTC_2407 paclitaxel 400 µM -1.54945934265046 0.0570307337931949 no 3172 0.0606356689416333 4535 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_530 4358-1714 28 µM -1.55661154698209 0.0562095338359374 no 3173 0.0597813703120222 4509 1564641
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.55930120423518 0.055903136603591 no 3174 0.0594625534262678 4547 688788
SGTC_2296 7971656 126.45 µM -1.56119560816836 0.0556881240382212 no 3175 0.0592388024640296 4521 666570
SGTC_1406 3909-7906 11.9 µM -1.56568503987265 0.0551811848583983 no 3176 0.058711185137868 4562 X1406
SGTC_142 0335-0849 62.6745 µM -1.56615927841026 0.0551278481887952 no 3177 0.0586556666647038 4493 3889043 YPR107C YTH1
SGTC_2748 diazoxide 86.69 µM -1.56891749526809 0.054818443835262 no 3178 0.0583335823637398 4609 3019 A potassium channel activatior.
SGTC_743 1275-0778 158 µM -1.56898867925919 0.054810476942253 no 3179 0.0583252884453586 4504 2849257 YMR203W TOM40
SGTC_2935 9038016 29.96 µM -1.57024837300651 0.0546696437071468 no 3180 0.058178669895173 4490 6463195
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.57543179553015 0.0540931477783015 no 3181 0.0575784050374727 4585 165521
SGTC_462 ag-879 158 µM -1.57828773051457 0.0537775750397571 no 3182 0.0572497616696329 4549 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_773 4358-1457 44.6 µM -1.57893179543027 0.053706609553242 no 3183 0.0571758510424504 4527 1186886
SGTC_1945 st075991 56.6 µM -1.58192218494583 0.0533780883944148 no 3184 0.0568336678582908 4520 1084980
SGTC_2866 9034245 58.44 µM -1.58314722888976 0.0532439670085006 no 3185 0.0566939555305863 4532 6462273
SGTC_459 nigericin 15.3 µM -1.58429195533558 0.0531188805927305 no 3186 0.0565636478208612 4551 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2195 6536160 144.242 µM -1.58483272680794 0.0530598705645038 no 3187 0.0565021722821379 4538 3834386
SGTC_2852 9023854 51.95 µM -1.58674068196168 0.0528520859636143 no 3188 0.0562856941993575 4542 19798528
SGTC_23 0213-0011 39.996 µM -1.58821149705344 0.0526923488200132 no 3189 0.0561192610960529 4523 627608
SGTC_3284 9108171 64.8615 µM -1.58870426695032 0.052638917544157 no 3190 0.0560635875785421 4518 8687505
SGTC_694 1315-0438 43.2 µM -1.59059894807906 0.0524338767386268 no 3191 0.055849930688212 4570 6793154
SGTC_110 0850-0284 111.64 µM -1.59103222902369 0.0523870766303663 no 3192 0.0558011614031197 4458 3906265
SGTC_2030 5175110 200 µM -1.59325716658518 0.0521472759485954 no 3193 0.0555512557282925 4542 2831986
SGTC_2403 6032726 181.2 µM -1.59788325705686 0.0516514736821701 no 3194 0.0550344804606428 4535 2881040
SGTC_2745 rifampicin 24.3 µM -1.60171289909879 0.0512438726217188 no 3195 0.054609555712285 4650 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1235 benzylparaben 21.5 µM -1.60660695596408 0.050726711974258 no 3196 0.054070307826968 4587 7180
SGTC_700 3453-2283 142 µM -1.61056520902738 0.0503114862953543 no 3197 0.0536372609547506 4575 565664
SGTC_199 4063-0024 41.6 µM -1.61909603363309 0.0494258027568823 no 3198 0.0527133010468545 4599 306215
SGTC_1997 st073024 93.8 µM -1.62254632799932 0.0490711416819809 no 3199 0.0523432109601088 4595 686268
SGTC_3040 9091894 49.47 µM -1.62453783331505 0.0488673589101758 no 3200 0.0521305363458445 4461 25236966
SGTC_3297 9117502 71.43 µM -1.62467861612528 0.0488529787988265 no 3201 0.0521155280384201 4571 7453720
SGTC_2870 9038528 12.99 µM -1.62708937245936 0.0486072589865776 no 3202 0.0518590589120987 4576 6463316
SGTC_2220 6782180 200 µM -1.63845649191712 0.0474619335071731 no 3203 0.0506632514692254 4514 833803
SGTC_2650 prasterone 100 µM -1.63925167369081 0.0473826288563439 no 3204 0.0505804280474134 4596 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1106 tegaserod maleate 11.7 µM -1.64951133288932 0.0463689114738053 no 3205 0.0495214616891215 4589 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2391 6285546 200 µM -1.6511611208172 0.0462075393317756 no 3206 0.0493528398007323 4578 846083
SGTC_206 4546-0025 72.014 µM -1.65322090561732 0.0460066972004399 no 3207 0.0491429566415858 4593 6620745 YIL048W NEO1
SGTC_1938 st074717 56.4 µM -1.6564640489371 0.0456918920853144 no 3208 0.0488139398738257 4447 17250979
SGTC_2027 5150920 200 µM -1.65975499643998 0.04537421908165 no 3209 0.0484818752969435 4528 786715
SGTC_2743 auranofin 4.32 µM -1.66342613179191 0.0450219454907222 no 3210 0.0481135829264958 4643 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1866 st057638 64 µM -1.66831744468942 0.0445560104289443 no 3211 0.0476263633673725 4581 688802
SGTC_356 1634-0012 32.5 µM -1.66865034464552 0.0445244408638716 no 3212 0.0475933476334175 4578 735457
SGTC_2008 4012253 172 µM -1.6698142612229 0.0444142059563919 no 3213 0.0474780589487992 4579 603940
SGTC_3016 9080866 49.47 µM -1.67903596342127 0.0435485695641574 no 3214 0.0465725175014329 4562 17066299
SGTC_2192 5915882 198.485 µM -1.68369454030675 0.043116476936594 no 3215 0.0461203585163559 4587 2876149
SGTC_112 phenothiazine 287.218 µM -1.68501456482665 0.0429946736122832 no 3216 0.0459928807380154 4543 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1882 5615643 20 µM -1.68697841919224 0.042813976464398 no 3217 0.045803750851062 4567 2253075
SGTC_2481 5478948 45.16 µM -1.69225359638377 0.0423316369545158 no 3218 0.0452988156839384 4570 77792
SGTC_865 0488-0499 301 µM -1.69310157870959 0.0422545128103076 no 3219 0.0452180669237432 4521 9634651
SGTC_1874 staurosporine 7.6 µM -1.70052792673708 0.0415839321269449 no 3220 0.0445158340119263 4581 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1492 4158-0558 28.5 µM -1.70641366514764 0.0410586111820232 no 3221 0.0439655440621475 4609 3967268
SGTC_2129 girgensonine 121.053 µM -1.70958938026951 0.0407774114901245 no 3222 0.0436709153994599 4569 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_767 0929-0023 86 µM -1.71051294148172 0.0406959269658022 no 3223 0.0435855311945846 4616 1204563
SGTC_577 r071-0003 38.6 µM -1.71586753997839 0.0402260985812428 no 3224 0.0430931444958581 4560 4568517 YMR134W ERG29
SGTC_1872 amphotericin b 148 nM -1.72341811042812 0.0395710855411726 no 3225 0.0424064710892812 4604 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1615 st002656 86.5 µM -1.72431251096711 0.0394940740849598 no 3226 0.0423257209705194 4598 1584458
SGTC_1081 sertraline 6 µM -1.74457997209995 0.0377814062168575 no 3227 0.040529004786744 4593 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3265 9137266 49.47 µM -1.74980521199997 0.0373498247589562 no 3228 0.0400759655147879 4593 17224265
SGTC_1841 st054148 70 µM -1.75138244771732 0.0372203462500328 no 3229 0.0399400271816604 4625 675442
SGTC_3261 9137475 49.47 µM -1.75188840491086 0.0371788889663169 no 3230 0.039896499363856 4641 17027690
SGTC_2611 pyromycin 23.93 µM -1.75438453500656 0.0369749121860828 no 3231 0.0396823197213696 4547 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1662 st014054 52 µM -1.76516144867317 0.0361047287660658 no 3232 0.0387683178454306 4680 2838777
SGTC_1432 4049-0298 68.4 µM -1.77584063865921 0.0352590506851751 no 3233 0.0378795936880196 4641 741646
SGTC_478 N-arachidonylglycine 10 µM -1.77952535129996 0.0349710582041242 no 3234 0.0375768362064142 4653 5283389
SGTC_475 α-linolenic acid 10 µM -1.78080133063856 0.034871780441304 no 3235 0.0374724559935921 4614 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3260 9137109 49.47 µM -1.78187922952585 0.0347880947438063 no 3236 0.037384464167419 4617 17478346
SGTC_334 1502-1024 68.5 µM -1.78256868415238 0.0347346535224387 no 3237 0.0373282706567072 4628 3296216
SGTC_671 0560-0003 407 µM -1.78722240495873 0.0343756936034341 no 3238 0.0369507747449703 4591 3238678
SGTC_1210 3013-0140 750 nM -1.78823290448875 0.0342981539702751 no 3239 0.0368692198339488 4644 905973
SGTC_1297 1068-0111 14.1 µM -1.79009794571792 0.0341554194766025 no 3240 0.036719083501359 4628 767057
SGTC_1079 idarubicin 2.36 µM -1.79169630113697 0.0340334837847883 no 3241 0.0365908136876558 4641 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2175 5807670 165.306 µM -1.79654101297944 0.0336660745871932 no 3242 0.0362042580515168 4595 241186
SGTC_1573 oleylamine 1.06 µM -1.79923375486235 0.0334632799976921 no 3243 0.035990856019822 4611 5356789 An amine of the fatty acid oleic acid.
SGTC_1614 st002383 48.6 µM -1.80581474923625 0.0329718849518499 no 3244 0.0354736404143923 4661 1947235
SGTC_2084 5306078 60.6385 µM -1.81344010058004 0.0324099621397176 no 3245 0.0348819846730586 4586 679340
SGTC_2861 9024595 19.48 µM -1.82717246605499 0.0314179385894755 no 3246 0.0338369211697416 4608 16482810
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.83676957110434 0.0307396558653012 no 3247 0.0331219598972168 4621 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2581 avocatin a 64 µM -1.8438009955303 0.0302504377235534 no 3248 0.0326060737961773 4573 6710728 A skin care supplement.
SGTC_2496 diffractaic acid 79.83 µM -1.84524315050696 0.0301509000878416 no 3249 0.0325010880467159 4623 94870 An apoptosis inducer which activates caspases.
SGTC_1634 st006576 41 µM -1.84695004812966 0.0300334409033792 no 3250 0.0323771901047406 4611 3915356
SGTC_774 k060-0086 136 µM -1.84904983231338 0.0298894661895663 no 3251 0.0322253087174079 4637 5911235
SGTC_1640 st009078 66.4 µM -1.85169017804302 0.0297092400698152 no 3252 0.032035162614639 4625 690618
SGTC_1736 st036774 51 µM -1.85222049546952 0.0296731503420854 no 3253 0.0319970834239875 4658 1272247
SGTC_3157 9099274 49.47 µM -1.8543655751006 0.0295275420835523 no 3254 0.0318434381774751 4640 17217662
SGTC_2983 9022671 12.99 µM -1.86533167968876 0.0287923983692556 no 3255 0.0310674636276445 4638 6405161
SGTC_733 4069-0007 56.1 µM -1.87973341112672 0.0278501133035298 no 3256 0.0300722098306146 4654 5717425 YNL287W SEC21
SGTC_2711 st079103 59.1 µM -1.88860691269518 0.0272824273753575 no 3257 0.0294722600238664 4615 54693780
SGTC_2143 5623677 140.463 µM -1.89748705060533 0.0267240126056212 no 3258 0.0288818431314522 4637 5375313
SGTC_1655 st012546 55.1 µM -1.89759433003891 0.0267173252889996 no 3259 0.0288747709563042 4655 720985 YLR208W SEC13
SGTC_2004 4023728 41.89 µM -1.89874079364591 0.0266459471457414 no 3260 0.0287992825623459 4603 360084 YDR527W RBA50
SGTC_3270 9137563 49.47 µM -1.90537485814938 0.0262360350787172 no 3261 0.0283656804926509 4658 17015724
SGTC_770 0389-1121 67.2 µM -1.91301345605784 0.0257705973337194 no 3262 0.0278731649208416 4687 6753108
SGTC_3127 9126946 49.47 µM -1.91379900464514 0.0257231263267774 no 3263 0.0278229213726205 4616 27243249
SGTC_2910 7948405 25.97 µM -1.91660155546589 0.0255543630465734 no 3264 0.0276442851302927 4641 2971328
SGTC_2700 st077718 96.8 µM -1.92651238198611 0.0249649742664905 no 3265 0.02702021364583 4640 904970
SGTC_2914 7968218 45.32 µM -1.93123138217167 0.0246883698202829 no 3266 0.0267272223640893 4647 2977111
SGTC_834 0312-0008 75.7 µM -1.93386153402317 0.0245353223632139 no 3267 0.0265650773294254 4687 6385573 YIL048W NEO1
SGTC_958 1222-0007 33 µM -1.93597198847123 0.0244130924134951 no 3268 0.0264355659018532 4682 7312461
SGTC_456 gingerol 170 µM -1.93667556978319 0.0243724572954337 no 3269 0.0263925069527334 4654 442793 A herb.
SGTC_3125 9127534 49.47 µM -1.93837794728231 0.0242743718873967 no 3270 0.0262885644475764 4613 1639235
SGTC_49 0717-0965 32.132 µM -1.94711068010976 0.0237764174057561 no 3271 0.0257607334319541 4701 5889349 YGL099W LSG1
SGTC_2523 spermine 47.74 µM -1.94771287869682 0.0237423979187655 no 3272 0.0257246641185565 4664 1103 A DNA binding polyamine.
SGTC_342 k048-0088 23.3 µM -1.9512101635914 0.0235456368325128 no 3273 0.0255160252230884 4678 6820570
SGTC_1570 verbenone 133 µM -1.95221426401165 0.0234893991286496 no 3274 0.0254563856925978 4664 29025 A natural terpanoid with antifungal properties.
SGTC_1762 st045503 25.4615 µM -1.95727091598757 0.0232079005949596 no 3275 0.025157812514906 4682 4645554
SGTC_2814 7977482 42.97 µM -1.9579448398194 0.0231705993058459 no 3276 0.0251182427895779 4650 6456762
SGTC_1416 3966-0321 25.3 µM -1.99258372135729 0.0213201949560201 no 3277 0.023153524592508 4725 582530 YLR208W SEC13
SGTC_2435 5706476 10.6 µM -2.00011206129725 0.0209350040529891 no 3278 0.0227440823283981 4666 5725375
SGTC_3314 9135860 59.4275 µM -2.0107331584794 0.0204015997044808 no 3279 0.0221768248257814 4671 25252478
SGTC_1923 st058458 19.1 µM -2.01230450672149 0.0203236712487941 no 3280 0.0220939238314858 4662 3534982
SGTC_1291 0993-0025 5.79 µM -2.01969857889277 0.0199603530489937 no 3281 0.021707331304254 4674 4353356
SGTC_895 0964-0006 13.7 µM -2.02940945330399 0.019491578837651 no 3282 0.0212083015256937 4687 6738897
SGTC_140 0062-0056 502.533 µM -2.03040547041944 0.0194440310835267 no 3283 0.0211576705333579 4614 3758964
SGTC_2716 st080858 38.6235 µM -2.06048608516669 0.0180537730675164 no 3284 0.0196760473749317 4682 5296050
SGTC_3292 9120825 59.784 µM -2.06771504201261 0.0177325909836309 no 3285 0.0193334133066565 4679 24824900
SGTC_2486 5283202 22.39 µM -2.07275735652756 0.0175114585890602 no 3286 0.0190974334443485 4699 1377751
SGTC_1414 3917-0015 5.4 µM -2.08432209497551 0.0170131593021022 no 3287 0.0185654394330256 4724 6618702
SGTC_2582 agaric acid 100 µM -2.10106501244236 0.0163132485164583 no 3288 0.0178176298385311 4395 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1319 1306-0155 43.7 µM -2.12094552529513 0.015514335546457 no 3289 0.0169631934652468 4733 3122360
SGTC_2995 9067767 71.4286 µM -2.12849807156106 0.0152197569578888 no 3290 0.0166479048373465 4699 11673567
SGTC_1850 st056238 17 µM -2.13552399039668 0.0149500456753147 no 3291 0.0163591163559719 4717 5393177
SGTC_3201 9113999 49.47 µM -2.14019497631829 0.0147730182831948 no 3292 0.016169506499545 4673 16649224
SGTC_135 0933-0004 26.348 µM -2.15870934627976 0.0140889598145434 no 3293 0.0154363616182366 4665 21230617 YGL099W LSG1
SGTC_1329 1447-1697 50.6 µM -2.16213547814107 0.0139654120053036 no 3294 0.0153038675432301 4724 2840515
SGTC_133 0724-0033 378.92 µM -2.16599005977613 0.0138275316704479 no 3295 0.015155973267135 4666 280309
SGTC_3024 9090631 49.47 µM -2.18685600001642 0.013101350393223 no 3296 0.0143765189301842 4729 25236383
SGTC_3240 9133527 49.47 µM -2.1889657647786 0.0130297945972688 no 3297 0.0142996642100943 4721 17617455
SGTC_2335 9018011 154.17 µM -2.19616130903345 0.012788282305262 no 3298 0.0140401998094753 4709 6458208
SGTC_2452 5863136 48.41 µM -2.20714921481802 0.0124269564147512 no 3299 0.013651818214974 4691 2184096
SGTC_1129 3453-1384 223 µM -2.23458130951183 0.0115632359986567 no 3300 0.0127224245097341 4690 1084452
SGTC_3034 9090421 49.47 µM -2.2364103253821 0.0115075484922124 no 3301 0.0126624527023747 4710 17173761
SGTC_2130 NSC 7 2.4545 µM -2.23828767165645 0.0114506318727857 no 3302 0.0126011507748298 4729 21448
SGTC_2442 5158906 48.48 µM -2.2519849293304 0.0110427160344715 no 3303 0.012161612205232 4725 1893835
SGTC_366 0181-0206 4.31 µM -2.25570889346763 0.010934022505142 no 3304 0.0120444341189669 4693 274874
SGTC_464 bw-b 70c 158 µM -2.26380523379225 0.0107009173787939 no 3305 0.0117930482422083 4726 5353454
SGTC_2515 chrysin 20.77 µM -2.28147848983173 0.0102070643117366 no 3306 0.011260074067478 4743 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1271 0832-2808 169 µM -2.29465354135392 0.00985195494143925 no 3307 0.0108764936331807 4746 3663794
SGTC_784 4579-0127 173 µM -2.29546891161712 0.00983033703776576 no 3308 0.0108531330320938 4743 1948547
SGTC_2828 7998861 71.43 µM -2.30255471233481 0.00964420914761409 no 3309 0.0106519548611809 4742 2988188
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.32219358715787 0.00914434688060934 no 3310 0.0101112570713512 4731 1241132 A phosphatase inhibitor.
SGTC_408 cantharidin 100 µM -2.32964361887223 0.00896074369578644 no 3311 0.00991249737091355 4743 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_161 4065-0411 162.148 µM -2.33458848420401 0.00884066990168635 no 3312 0.00978246435839782 4732 1906281 YLR208W SEC13
SGTC_370 0180-0345 38.7 µM -2.34937619247785 0.00848996112820439 no 3313 0.00940244838537453 4646 3989527
SGTC_1186 1319-0216 26 µM -2.36467639670853 0.00814000762356972 no 3314 0.0090229156395278 4766 4565136
SGTC_839 0122-0028 230 µM -2.38056465935166 0.007790081713953 no 3315 0.00864306353061259 4754 759448
SGTC_367 0335-0881 7.1 µM -2.38528748217966 0.00768864999338618 no 3316 0.00853288969502118 4687 23828853
SGTC_2754 granisetron 64.02 µM -2.40491167386223 0.00727952864410159 no 3317 0.00808818750321462 4724 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2848 9016370 25.97 µM -2.40547418054151 0.00726809009929378 no 3318 0.00807574662066083 4704 7894410
SGTC_2 0422-0095 29 µM -2.42734037482723 0.00683554860274726 no 3319 0.0076049892223849 4691 6790840
SGTC_3205 9113483 49.47 µM -2.43831489281973 0.00662715318129435 no 3320 0.00737795691734708 4713 17018033
SGTC_2477 5967686 25.23 µM -2.44357052796743 0.00652935779345242 no 3321 0.00727136340427533 4733 776118
SGTC_518 1021-0119 62.6 µM -2.44488453897764 0.0065051073864593 no 3322 0.00724492606743855 4736 1097762
SGTC_2426 5582046 32.21 µM -2.45198238877655 0.00637548722223457 no 3323 0.00710358075652116 4742 2251934
SGTC_1426 4048-4480 71.7 µM -2.45595732560213 0.00630390034454713 no 3324 0.00702549209424616 4771 14224343
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.47019239669079 0.00605333590018159 no 3325 0.00675202006325218 4755 756377
SGTC_791 1348-1292 225 µM -2.53287215463391 0.0050519931766907 no 3326 0.0056566103120141 4750 5437054
SGTC_1332 1480-0653 17.5 µM -2.54526738186032 0.00487242145701464 no 3327 0.00545970450683187 4771 5749438
SGTC_2708 st078559 56 µM -2.56702208185788 0.00457097018239912 no 3328 0.00512880400002232 4761 17250902
SGTC_1654 st012436 41.8 µM -2.58120288237964 0.00438354330695565 no 3329 0.00492283507174297 4784 4323132
SGTC_2443 5493264 126.67 µM -2.58781946372479 0.00429846557111842 no 3330 0.00482927937669911 4784 5340055
SGTC_807 1315-0151 48 µM -2.59530096173044 0.00420404718356166 no 3331 0.00472540617415862 4756 4011080
SGTC_1606 st000094 49.2 µM -2.6042159284307 0.00409396321983904 no 3332 0.0046042360739162 4763 1242210
SGTC_3039 9090270 49.47 µM -2.64445021354604 0.00362857009750133 no 3333 0.00409118714054604 4771 17173750
SGTC_2567 aureobasidin a 60 nM -2.69368023987096 0.00312403116289606 no 3334 0.0035333962543674 4763 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2602 kawain 100 µM -2.70067278048213 0.00305773682873279 no 3335 0.00345996916593391 4758 5369129
SGTC_1759 st043059 70 µM -2.70213439111494 0.00304404085205955 no 3336 0.00344479543597459 4783 669426
SGTC_1306 1185-0270 9.02 µM -2.70275099931412 0.00303827953518984 no 3337 0.00343841205992383 4789 1548076
SGTC_351 caspofungin 25 nM -2.7261307414656 0.00282694697022227 no 3338 0.00320408048855812 4775 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1641 st009299 47.1 µM -2.77950650261041 0.00239332889467411 no 3339 0.00272207817688748 4787 4046054
SGTC_2918 7977171 22.06 µM -2.78311960232082 0.00236627514537828 no 3340 0.00269194775633047 4776 2236483
SGTC_3308 9128332 17.569 µM -2.79012646231555 0.00231459754082384 no 3341 0.00263437288035862 4757 17332805 YDL196W YDL196W
SGTC_3215 9129942 49.47 µM -2.81145075992933 0.00216355124885644 no 3342 0.00246593194551797 4770 17682944
SGTC_53 0973-0023 39.979 µM -2.87099553131502 0.00178790319591339 no 3343 0.00204590654667951 4753 674768
SGTC_1411 3909-8223 150 µM -2.89241706671133 0.00166798809486173 no 3344 0.00191145047486552 4805 X1411
SGTC_58 0957-0393 9 µM -2.90317840396574 0.00161055395714525 no 3345 0.0018469807063586 4426 6997992
SGTC_967 1306-0166 352 µM -2.92767081853482 0.00148649474898458 no 3346 0.00170755703183346 4785 4437607
SGTC_766 1391-0721 126 µM -2.96148335220144 0.00132953549088668 no 3347 0.00153080522198054 4791 1020919 YIL115C NUP159
SGTC_2588 indole-3-carbinol 100 µM -2.96158896497368 0.00132906990713889 no 3348 0.00153028030093945 4774 3712 Induces cell cycle arrest.
SGTC_634 1611-4317 11.2 µM -3.15128262371521 0.0006965105798777 yes 3349 0.000812775562076316 4799 2843522
SGTC_2707 st078556 66.6 µM -3.21211393617052 0.000562072716207927 yes 3350 0.000658810542341766 4797 17250899
SGTC_2584 androsterone 48.74 µM -3.55427850259829 0.000157507319999423 yes 3351 0.000189508810409105 4770 2754130 A steroid.
SGTC_2488 5268135 45.7 µM -4.21944419274927 9.61544582983737e-06 yes 3352 1.2245266718703e-05 4807 1270356 YLR208W SEC13
SGTC_803 4488-1585 147 µM -4.26892978182612 7.67661665104927e-06 yes 3353 9.8206541329509e-06 4807 747204