SGTCid condition conc unit NTF2|YER009W.score NTF2|YER009W.strain.pval NTF2|YER009W.strain.significant NTF2|YER009W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_769 0302-0231 76 µM 11.3505663139651 4.1877100746361e-32 yes 1 3.68419517994182e-30 1 571869 YER009W NTF2
SGTC_2844 9010103 25.97 µM 5.7683226751634 1.19524151305922e-09 yes 2 4.00321984844088e-09 4 2480525
SGTC_2128 5255449 168.493 µM 4.88002809983293 2.19628828015874e-07 yes 3 5.30353632392169e-07 1 736008
SGTC_2849 9019321 12.99 µM 4.63521729368501 8.00481971221999e-07 yes 4 1.78281363312222e-06 4 16489627
SGTC_1042 0350-0096 82 µM 4.63190121568012 8.14282952986341e-07 yes 5 1.81161516226962e-06 5 3122515
SGTC_970 1315-0089 19.5 µM 4.18002666344675 7.52478637577802e-06 yes 6 1.45737458827961e-05 8 6811083 YLR033W RSC58
SGTC_909 3448-9333 149 µM 3.80067559528926 4.14137116637022e-05 yes 7 7.21510589365745e-05 2 3344074
SGTC_757 1066-0008 322 µM 3.65603257448425 7.63481172210163e-05 yes 8 0.000128074410036876 5 6842497
SGTC_898 1000-0849 28.3 µM 3.56905840600236 0.000109170001941274 yes 9 0.000179133277877959 3 6751807
SGTC_2974 9094440 9.66 µM 3.49798197062876 0.000145396449804896 yes 10 0.000234396411225632 21 25236134
SGTC_915 methyl methanesulfonate (MMS) 110 mM 3.45158360267444 0.000174823374895096 yes 11 0.000278653535848927 13 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2161 5662504 8.5105 µM 3.32326546241137 0.000287783881849123 yes 12 0.000444851016829691 12 2859334
SGTC_724 3910-0327 137 µM 3.30109827040203 0.000313135902740947 yes 13 0.000481535720446218 10 2885483
SGTC_1208 2323-2347 50.3 µM 3.26017902710735 0.000365471742677246 yes 14 0.00055670955058399 2 5412760
SGTC_50 0929-0078 56.389 µM 3.20006534606841 0.000457232376093183 yes 15 0.000686982163412626 11 1377751
SGTC_2683 piperine 63.03 µM 3.19078513471925 0.000473167815667483 yes 16 0.000709433785957144 6 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3291 9121177 71.43 µM 3.0855509910975 0.00069360293747947 yes 17 0.00101587691537086 5 17015612
SGTC_532 1548-0774 215 µM 3.06253655716619 0.000753000639274402 yes 18 0.00109734833118979 13 5932993
SGTC_1044 1222-0021 1.78 µM 3.05157190574702 0.000782916757149831 yes 19 0.0011382325792075 51 4306703
SGTC_1682 st012968 530 nM 3.0431322207209 0.00080668491958855 yes 20 0.00117064718211443 13 24207270
SGTC_907 3448-6986 75.5 µM 3.02346968266032 0.000864657736709363 yes 21 0.00124947033091446 17 590582
SGTC_1282 0886-0010 32.4 µM 3.01482868962889 0.000891326700357604 yes 22 0.00128562219813783 29 2836211 YNL267W PIK1
SGTC_533 1222-0222 6.71 µM 2.9977358721405 0.000946320728121037 yes 23 0.00135996645007099 25 3982874
SGTC_1416 3966-0321 25.3 µM 2.96661265938681 0.00105452867248092 no 24 0.00150550013128441 14 582530 YLR208W SEC13
SGTC_3067 9117431 49.47 µM 2.92843784791515 0.00120270915625679 no 25 0.00170334967058461 27 17150885
SGTC_2665 lovastatin 100 µM 2.87943084804935 0.00142083778797384 no 26 0.00199196828380534 10 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_695 3505-6186 243 µM 2.8686450672146 0.00147345311028218 no 27 0.0020611705439303 28 1819379
SGTC_2614 arthonioic acid 13.39 µM 2.86506366895364 0.00149131329850216 no 28 0.00208462702698846 10 6710684
SGTC_2372 9071633 200 µM 2.82746089257045 0.00169112230883801 no 29 0.00234593729082665 10 21321366
SGTC_2138 5575593 77.673 µM 2.80120042562436 0.00184480140636789 no 30 0.00254564437279147 7 762213
SGTC_1414 3917-0015 5.4 µM 2.79313291509503 0.00189450143994024 no 31 0.00261001191550928 9 6618702
SGTC_3143 9086658 49.47 µM 2.76950949829118 0.00204711151272481 no 32 0.00280703836693547 36 25236626
SGTC_181 1447-1644 8.07 µM 2.76382728672182 0.00208544575233484 no 33 0.00285638843863625 31 534600
SGTC_3354 9151612 71.43 µM 2.75964521562357 0.00211407429538263 no 34 0.00289320819712753 6 27261949
SGTC_941 3237-0776 460 µM 2.70261721304673 0.00254166268676402 no 35 0.00343979616571035 13 760008
SGTC_3074 9116018 49.47 µM 2.69344211573569 0.00261733048109728 no 36 0.00353592119534375 19 17027303
SGTC_1412 3909-8563 178 µM 2.68761200776711 0.00266646334542605 no 37 0.00359824809858725 7 23767530
SGTC_271 rotenone 740 µM 2.6729295057754 0.00279391026708211 no 38 0.00375960247940566 8 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_366 0181-0206 4.31 µM 2.65944295274595 0.00291579180131022 no 39 0.00391349918768488 23 274874
SGTC_1246 0422-0085 105 µM 2.65740532922726 0.00293461745093969 no 40 0.00393723517920323 30 264295
SGTC_374 0880-0231 82.3 µM 2.63386077767934 0.00316023047155856 no 41 0.00422100477314677 31 6833587
SGTC_526 4469-0568 170 µM 2.62394879864631 0.00325979328213993 no 42 0.00434584250889455 24 2901964
SGTC_774 k060-0086 136 µM 2.62240242169546 0.00327557805878398 no 43 0.00436561332536165 24 5911235
SGTC_475 α-linolenic acid 10 µM 2.61344727874306 0.00336834764378309 no 44 0.00448169558132533 29 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1056 3448-1962 115 µM 2.60395906378515 0.00346920988871665 no 45 0.00460768814689541 23 715507
SGTC_771 0250-0039 27.3 µM 2.60094408002596 0.00350182330273846 no 46 0.00464838034102695 20 3005115
SGTC_1971 st069429 63.5 µM 2.59788160965901 0.00353523200932322 no 47 0.00469004141963518 18 1246522 YGL099W LSG1
SGTC_1751 st044839 27.194 µM 2.5965418206009 0.00354993764059739 no 48 0.00470837207859762 14 5291326
SGTC_3137 9097352 49.47 µM 2.55069764867831 0.00408740607290769 no 49 0.00537537731989406 34 44120435
SGTC_1035 k081-0041 55.2 µM 2.54528653410666 0.00415542659094778 no 50 0.00545940503530005 25 731709
SGTC_1040 k898-0338 155 µM 2.52775848531348 0.00438277045267824 no 51 0.00573966439817351 18 20969351
SGTC_781 4335-2806 94.4 µM 2.52525123391873 0.00441618309572551 no 52 0.00578078017220453 22 845254
SGTC_2992 9074591 71.4286 µM 2.51516883118789 0.00455285438182229 no 53 0.00594876971103325 17 17741321
SGTC_2817 7995342 71.43 µM 2.51023222988628 0.00462113917986917 no 54 0.00603258934386679 34 18879975
SGTC_2991 9074669 71.4286 µM 2.50900666915651 0.00463823255203158 no 55 0.00605355992725164 62 17333109
SGTC_1873 rapamycin 2 nM 2.47964602013884 0.005064963621292 no 56 0.00657564347969968 40 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1984 st072354 53.1 µM 2.46813463382199 0.00524158939843003 no 57 0.00679096126337044 20 5762938
SGTC_353 1988-1175 58.3 µM 2.44107105663089 0.00567859622112769 no 58 0.00732188656483347 43 2788357
SGTC_553 k007-0256 45.7 µM 2.42316783949337 0.00598518033143821 no 59 0.00769290817435901 44 6287000
SGTC_1112 tnp00069 1.16933 µM 2.4207715035664 0.00602731072357846 no 60 0.00774380447483949 21 145826
SGTC_208 k072-0098 12.366 µM 2.40316413877865 0.0063450135888187 no 61 0.00812694501144396 48 5948901
SGTC_281 1672-3440 14.9 µM 2.40139042757173 0.00637782555667981 no 62 0.00816644985859811 21 6833000
SGTC_2681 menadione 3.18 µM 2.39927576791754 0.00641714092021963 no 63 0.00821376886410062 29 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2846 9008642 19.48 µM 2.39772157793697 0.00644617270827647 no 64 0.00824869983238697 38 2992898
SGTC_768 0384-0033 77.3 µM 2.39363217894863 0.00652311727923859 no 65 0.00834123457851285 51 3965305 YMR134W ERG29
SGTC_2270 7924575 90.91 µM 2.39221004536498 0.00655006534509514 no 66 0.00837362749225414 34 1262135
SGTC_1503 4585-0012 61.3 µM 2.38417893537104 0.00670410292122618 no 67 0.00855863856452594 33 2922052
SGTC_894 0960-0238 55.9 µM 2.38400148280624 0.00670754233181844 no 68 0.00856276668306271 33 6741907 YDL195W SEC31
SGTC_777 1315-0167 517 µM 2.3429933114393 0.0075454214976375 no 69 0.00956486301640237 26 4221767
SGTC_3313 9133968 57.047 µM 2.34116332434982 0.0075848715352639 no 70 0.00961187774184663 19 1494643
SGTC_2097 5376186 200 µM 2.31615200763484 0.00814254414670178 no 71 0.0102749852590985 31 742755
SGTC_2604 4'-hydroxychalcone 11.32 µM 2.31453972786008 0.0081796984846417 no 72 0.0103190673307386 54 5282362
SGTC_1349 flufenamic acid 69 µM 2.31100873385332 0.00826158952923976 no 73 0.0104161862406584 29 3371 A non-steroidal anti-inflammatory.
SGTC_760 0568-0725 82.9 µM 2.30270681648009 0.0084569707390826 no 74 0.0106476722080631 33 3916171
SGTC_896 0964-0007 44.5 µM 2.28395392080168 0.00891329989804859 no 75 0.0111871195868208 39 6756758
SGTC_207 4185-0010 4.486 µM 2.26556938329032 0.00938146514007816 no 76 0.0117388807105571 53 3761753
SGTC_2004 4023728 41.89 µM 2.26197859370913 0.00947537523113093 no 77 0.0118493629460847 66 360084 YDR527W RBA50
SGTC_659 k018-0002 107 µM 2.25991656248114 0.00952967435634681 no 78 0.0119132148901126 45 6797879 YHR007C ERG11
SGTC_2649 anisomycin 9.56 µM 2.25263705145686 0.00972354584681121 no 79 0.0121410214748073 35 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2002 4023503 131 µM 2.22979499963797 0.0103544301853709 no 80 0.012880527759941 57 4736863 YCR052W RSC6
SGTC_674 0498-0004 451 µM 2.22638486072186 0.010451614399719 no 81 0.0129942068326285 66 4231473
SGTC_2046 4110841 106 µM 2.22583869754525 0.0104672529205034 no 82 0.0130124938701865 48 44119630 YMR134W ERG29
SGTC_2056 5235370 200 µM 2.22452628770442 0.010504915106533 no 83 0.0130565279329021 38 5511916
SGTC_1684 st024538 14.6195 µM 2.22069073581155 0.0106156614389902 no 84 0.0131859576743173 33 6732859
SGTC_2314 7727897 200 µM 2.21380574867528 0.0108170088058927 no 85 0.0134210722286602 27 900724
SGTC_1741 st038134 10.228 µM 2.19264806820513 0.0114566970617491 no 86 0.0141663725170783 37 1272587
SGTC_2959 9079155 11 µM 2.181166596678 0.0118173973311733 no 87 0.0145855482515753 51 16189457
SGTC_982 1491-0518 27.5 µM 2.16546329164216 0.0123266610002355 no 88 0.0151761118187882 29 3091256
SGTC_2458 5808907 16.39 µM 2.16506814415195 0.0123397172833992 no 89 0.0151912335485186 47 2731747
SGTC_1410 3909-8106 77.9 µM 2.16214917019999 0.0124365363261371 no 90 0.0153033400146442 37 1039210
SGTC_2594 a-mangostin 100 µM 2.13925547029151 0.0132189680531284 no 91 0.0162074919732795 48 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2797 7859098 81.82 µM 2.13764027811052 0.013275741962942 no 92 0.0162729750295276 40 972681
SGTC_2825 7998094 58.44 µM 2.13257356902754 0.0134552052712713 no 93 0.016479861724383 58 2987815
SGTC_2132 5317594 122.667 µM 2.09535930431203 0.0148386709370604 no 94 0.0180695321426965 39 794577
SGTC_2950 9072895 21.46 µM 2.09097681233334 0.0150093767281108 no 95 0.0182650713091057 40 17332245
SGTC_3274 9138298 49.47 µM 2.09028076315567 0.0150366438178513 no 96 0.0182962931377487 50 17015756
SGTC_1432 4049-0298 68.4 µM 2.08471849084993 0.0152560742037916 no 97 0.0185474305982617 30 741646
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.08054391579122 0.0154225618180735 no 98 0.0187378359777125 55 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1464 k208-0027 110 µM 2.07350506774224 0.0157068132756216 no 99 0.0190626499887794 40 X1464
SGTC_1289 0976-0073 69.1 µM 2.07183725061988 0.0157748199756113 no 100 0.0191403107339683 45 3391136
SGTC_2892 9047358 58.44 µM 2.06878325917845 0.0159000039050827 no 101 0.019283215030539 36 6466771
SGTC_1753 st043925 64 µM 2.05809208164759 0.0163449703913774 no 102 0.0197906474927354 43 670181
SGTC_3087 9117406 49.47 µM 2.04817759095607 0.0167670989677793 no 103 0.0202713006773038 43 42546093
SGTC_153 4077-0274 519.67 µM 2.04283582479892 0.0169983763637824 no 104 0.0205343464413444 54 3121976
SGTC_637 1181-0519 7.26 µM 2.03133289673896 0.0175056811158592 no 105 0.021110618216381 57 6252091 YGR060W ERG25
SGTC_3129 9127257 49.47 µM 2.0277558251282 0.0176660495450953 no 106 0.021292587469161 43 837894
SGTC_469 w7 172 µM 2.02221691869212 0.0179168446670528 no 107 0.0215769735894112 31 45115570 A P450 inhibitor.
SGTC_625 k213-0058 121 µM 2.01384414111661 0.0183017152969102 no 108 0.0220129498478875 83 3655420
SGTC_673 1082-0474 110 µM 2.01332422768212 0.018325844630431 no 109 0.0220402655906228 116 3098046
SGTC_2704 st078022 71.1 µM 2.0118585664917 0.018394012330616 no 110 0.0221174240651955 53 54697681
SGTC_2166 5933061 31.504 µM 2.00968793946138 0.0184953646245119 no 111 0.0222321136120873 31 2877375
SGTC_651 3253-0966 34.4 µM 2.00361445186521 0.0187814820317057 no 112 0.0225556882767475 49 781462
SGTC_3276 9139060 49.47 µM 2.00093060544549 0.0189091109126414 no 113 0.0226999343965891 58 4870619
SGTC_640 3381-0960 37.1 µM 1.99975547546196 0.0189652254020196 no 114 0.0227633372929603 47 1745025
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.98674795953263 0.0195958748422073 no 115 0.0234751670938169 41 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_215 1287-0124 461.5 µM 1.98108906524844 0.0198757468918325 no 116 0.0237906431691803 29 5560863
SGTC_3134 9127454 49.47 µM 1.96965613781843 0.0204515447029919 no 117 0.024438896561245 27 24262820
SGTC_1497 4476-2978 41.3 µM 1.96719551685509 0.0205773007567357 no 118 0.0245803373385249 57 1528379
SGTC_2546 rhodinyl acetate 100 µM 1.96526711715546 0.0206763136377911 no 119 0.0246916646797652 57 6708682
SGTC_1204 4049-0315 18.3 µM 1.96283555117623 0.020801736272451 no 120 0.0248326427169794 55 588402
SGTC_188 3229-0966 278.469 µM 1.94947712063193 0.0215023241898449 no 121 0.0256192362538951 94 5722370
SGTC_293 4049-0273 38.5 µM 1.93725962256163 0.0221604361139276 no 122 0.0263568076511758 55 1380311
SGTC_393 acivicin 6.25 µM 1.93382551319029 0.0223484510407284 no 123 0.026567292398399 62 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1688 st021091 57.6 µM 1.93099711999813 0.0225043123099237 no 124 0.0267417042878653 44 3656366
SGTC_1374 2889-5571 141 µM 1.9293230854035 0.02259699262456 no 125 0.0268453827801714 106 2853281
SGTC_1756 st041558 35.5 µM 1.92865008121623 0.0226343430317409 no 126 0.0268871586313789 51 3955792
SGTC_1693 xanthone 101.9 µM 1.92294354772237 0.0229531407608529 no 127 0.0272435699599402 68 7020 An insecticide.
SGTC_883 0850-0245 24.6 µM 1.91860781742151 0.0231978791837593 no 128 0.0275169927566657 72 6823229 YPR165W RHO1
SGTC_3109 9122853 49.47 µM 1.91345517191479 0.0234915830290543 no 129 0.02784490355984 46 1234709
SGTC_1493 4348-0038 111 µM 1.90168939303864 0.0241739829239027 no 130 0.0286058866849032 96 800424
SGTC_2909 7941780 10.49 µM 1.89618994095205 0.0244986097371029 no 131 0.0289674664136036 62 1243215
SGTC_948 3448-0295 75.3 µM 1.89143053720509 0.0247824983450465 no 132 0.02928344769424 61 678569
SGTC_2814 7977482 42.97 µM 1.88646791090601 0.0250814421974648 no 133 0.0296159643302374 84 6456762
SGTC_1876 myriocin 605 nM 1.88640733168829 0.0250851100239614 no 134 0.0296200426696955 67 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2721 ifenprodil 61.44 µM 1.884533296991 0.0251987975205928 no 135 0.0297464376369981 61 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.88319675866928 0.0252801415449854 no 136 0.029836854080078 70 5024745
SGTC_1640 st009078 66.4 µM 1.88246959835367 0.0253244901082731 no 137 0.0298861419548854 57 690618
SGTC_2710 st078562 53.7235 µM 1.87610535784787 0.0257154254435493 no 138 0.0303204070679148 65 17250908
SGTC_2271 7849410 118.62 µM 1.87167808233555 0.0259903480210036 no 139 0.0306255767919041 51 972430
SGTC_2396 5342950 42.78 µM 1.86934588388713 0.0261361576118995 no 140 0.0307873541626501 116 1886677
SGTC_1415 3966-0071 78.1 µM 1.86708584286498 0.026278107919039 no 141 0.0309448005471102 60 2893185
SGTC_2720 fluspirilene 36.88 µM 1.86599516190091 0.0263468424365341 no 142 0.0310210211941287 46 3396 An atypical antipsychotic.
SGTC_2723 salbutamol 83.58 µM 1.86352473388407 0.0265030841698252 no 143 0.0311942379901087 37 9884233 β2-adrenoceptor agonist
SGTC_392 N-ethylmaleimide 8.33 µM 1.86129902897868 0.0266445106574501 no 144 0.0313509801127732 73 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3295 9122362 53.5725 µM 1.85374542827142 0.027129192229565 no 145 0.0318877945717284 72 4730473
SGTC_1269 0831-0796 3.05 µM 1.82828366350578 0.0288174635032925 no 146 0.0337534951585813 67 927758
SGTC_1758 st042942 75.2445 µM 1.82217289763529 0.0292353895102826 no 147 0.0342143777589324 65 669317
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.8190511566842 0.0294508261956808 no 148 0.0344518128896302 64 551469
SGTC_3042 9091578 49.47 µM 1.81842244318289 0.0294943738598781 no 149 0.0344997953435719 46 25236497
SGTC_2883 9059145 45.46 µM 1.81140611276366 0.0299839948860362 no 150 0.0350390052230536 69 16476510
SGTC_2492 derrusnin 100 µM 1.80617967756986 0.0303530759726989 no 151 0.0354451391201016 70 1715307 Part of coumarin class of compounds.
SGTC_3323 9138564 53.9225 µM 1.79677564904511 0.0310266500656074 no 152 0.0361856218398895 71 43912313 YNL103W MET4
SGTC_2722 naftopidil 47.16 µM 1.79565023713881 0.031108081322479 no 153 0.0362750803999866 57 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2806 7952793 58.44 µM 1.79426466668181 0.0312085796000801 no 154 0.0363854674397574 72 2972490
SGTC_600 1495-0418 41.6 µM 1.79370680500116 0.0312491182135911 no 155 0.0364299892921162 79 5377768
SGTC_1189 1431-2119 7.28 µM 1.7895017768511 0.0315560920227455 no 156 0.0367670207908707 85 3107275
SGTC_2280 7785178 200 µM 1.78219288620827 0.0320955821581701 no 157 0.037358891240757 57 2954328
SGTC_1794 st048918 76.9 µM 1.7740445502733 0.0327059878197544 no 158 0.0380278907754608 51 672303
SGTC_2517 totarol 10 µM 1.77186074836461 0.032871196898589 no 159 0.0382088377402184 59 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_306 1672-3436 11.6 µM 1.76549976298429 0.0333563423070679 no 160 0.038739905016079 62 6797378
SGTC_351 caspofungin 25 nM 1.76035886424003 0.0337527278122313 no 161 0.039173489689304 101 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1487 3970-0795 2.82 µM 1.75541786067162 0.0341373451344934 no 162 0.0395939296071675 73 3765103
SGTC_2942 9052777 62.25 µM 1.75161426947412 0.0344358724537773 no 163 0.0399200786207066 90 6469503
SGTC_279 1273-0055 2.93 µM 1.74946103346199 0.034605819273812 no 164 0.0401056793857754 74 2847562
SGTC_960 1222-0186 7.7 µM 1.74810456443515 0.0347132335277088 no 165 0.0402229613849709 75 3126296
SGTC_1779 st039427 55 µM 1.74656728644161 0.0348352962485957 no 166 0.0403562129550068 63 1124498
SGTC_455 paf C-16 10 µM 1.74408709568428 0.0350329706957453 no 167 0.0405719519334462 77 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2675 theaflavin digallate 100 µM 1.74334776271498 0.0350920742907134 no 168 0.0406364435128686 73 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_738 1315-0003 72.4 µM 1.73945753053515 0.0354044157514588 no 169 0.0409771581483245 65 6251474
SGTC_1229 0139-0193 12.2 µM 1.73913456738245 0.0354304481913166 no 170 0.0410055477897762 100 3090752
SGTC_3037 9091026 49.47 µM 1.7376688631959 0.0355487885808099 no 171 0.0411345890842464 81 25236398 YIL048W NEO1
SGTC_2656 pseudo-anisatin 100 µM 1.72401336770416 0.0366669734640302 no 172 0.0423527149849162 49 6708809 A neurotoxin.
SGTC_1742 st038235 28.8875 µM 1.72074205876403 0.0369390743889525 no 173 0.0426488203403334 79 564103 YBR002C RER2
SGTC_2537 larixol 68.93 µM 1.72032523843816 0.0369738629350833 no 174 0.0426866691192684 79 6708759
SGTC_3083 9117465 49.47 µM 1.71607305076052 0.037330290382305 no 175 0.043074336483971 73 16420915
SGTC_248 streptozotocin 5.23457 mM 1.71593167707064 0.0373421886697188 no 176 0.0430872740617034 94 5300 DNA alkylating agent.
SGTC_2103 5378138 10 µM 1.7156627180243 0.0373648333443389 no 177 0.0431118960674354 56 244142
SGTC_2152 5568786 200 µM 1.71453452263577 0.0374599425993266 no 178 0.0432153011964921 72 5399883
SGTC_113 0099-0221 2.5 µM 1.703456600218 0.0384043759648297 no 179 0.0442413266239734 73 89219
SGTC_3104 9120930 49.47 µM 1.69698686348978 0.0389648640996846 no 180 0.0448495720678881 83 17014836
SGTC_2243 6634756 200 µM 1.69592863573137 0.0390571715133287 no 181 0.044949697925239 43 885676
SGTC_37 0566-0070 1.56 µM 1.69283278891152 0.0393282396406888 no 182 0.0452436497732029 70 1626686
SGTC_1248 0469-0687 58.6 µM 1.69278619685999 0.0393323308400338 no 183 0.0452480854909336 79 4017482
SGTC_971 1315-0384 26.7 µM 1.69191093090001 0.03940925140814 no 184 0.0453314787508622 80 6769120
SGTC_2651 TUB2.036 5 µM 1.69020491395424 0.0395595322006042 no 185 0.0454943793029732 102 15992207 YFL037W TUB2
SGTC_1459 k035-0031 35.7 µM 1.68657325932363 0.0398809921560446 no 186 0.0458427186968844 59 3877128 YMR208W ERG12
SGTC_548 1436-0017 110 µM 1.68607864804384 0.0399249370435105 no 187 0.0458903259932872 77 9677137
SGTC_557 1315-0110 16.2 µM 1.68341429421191 0.0401623351987123 no 188 0.0461474590077995 66 6833801
SGTC_398 bronopol 33.3 µM 1.67756036762423 0.0406879577168128 no 189 0.0467164776309418 93 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1280 0880-0253 10.1 µM 1.67261503343529 0.0411363358720114 no 190 0.0472015527326187 73 6836607
SGTC_2719 novobiocin 32.65 µM 1.66912166432284 0.0414554771043896 no 191 0.0475466353191112 62 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1365 1672-3266 55.4 µM 1.65973043336495 0.0423233806729937 no 192 0.0484843470628262 91 6415873
SGTC_3273 9137859 49.47 µM 1.651167223512 0.0431275191303052 no 193 0.049352216907188 87 2377234
SGTC_2125 5246583 200 µM 1.65008299243516 0.0432302096089391 no 194 0.0494629813996193 96 835267
SGTC_1102 cgs 12066b 26.1 µM 1.649476304561 0.0432877567762292 no 195 0.0495250468510904 75 6438352 A 5-HT1B full agonist.
SGTC_1060 3448-7350 82 µM 1.6483407964858 0.043395631230478 no 196 0.0496413787529175 89 570178
SGTC_2657 nystatin 74.44 µM 1.64084775117681 0.044112930647305 no 197 0.0504145115816371 68 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2214 7179297 48.276 µM 1.63920213141086 0.0442717369413958 no 198 0.0505855850498799 50 769744
SGTC_47 0149-0135 24.25 µM 1.63679941083405 0.0445044325126882 no 199 0.0508361944510844 86 5239155
SGTC_984 1492-0255 2.91 µM 1.63626308923585 0.0445565077791791 no 200 0.0508922687848118 64 1585198
SGTC_2622 2-methoxyxanthone 59.94 µM 1.63614189790852 0.0445682819009284 no 201 0.0509049465879798 78 71034 A hepatoprotective.
SGTC_1321 1326-2144 215 µM 1.63498782510534 0.0446805293496423 no 202 0.0510257999449082 84 3513030
SGTC_169 k015-0017 16.025 µM 1.63384720432607 0.0447916920315709 no 203 0.0511454688957666 80 1840002
SGTC_2534 helenine 20.12 µM 1.63338244480812 0.0448370503983711 no 204 0.0511942934277143 93 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_843 0310-0051 143 µM 1.62646001751468 0.0455170346355067 no 205 0.0519259161078062 79 2065037
SGTC_1213 1315-0166 115 µM 1.62355855599465 0.0458044979323369 no 206 0.0522350283062385 96 768401
SGTC_1646 st011709 75.6 µM 1.62301315871351 0.0458586959171431 no 207 0.0522932959815387 93 5757843
SGTC_2001 4023502 57.655 µM 1.6220614840967 0.045953390469181 no 208 0.0523950920044851 73 108941 YCR052W RSC6
SGTC_3145 9085516 49.47 µM 1.61996469979567 0.0461625813574262 no 209 0.0526199300190613 88 25236195
SGTC_2674 ligustilide 100 µM 1.61934497015877 0.0462245564405491 no 210 0.0526865299748661 85 5319022 A signalling regulator.
SGTC_1266 0828-0227 32.9 µM 1.61560683052772 0.0465998014864064 no 211 0.0530896730828308 92 3913820
SGTC_1624 st003710 6.25 µM 1.6118573436006 0.046978637317601 no 212 0.0534964931825196 72 24207033
SGTC_1348 1493-0373 93.8 µM 1.61169948515234 0.0469946408343021 no 213 0.0535136748912891 89 3010129
SGTC_1525 8-methoxypsoralen 92.5 µM 1.61110027864031 0.0470554275294278 no 214 0.0535789338282018 103 4114 Related to psoralen; DNA damaging agent.
SGTC_3185 9108267 49.47 µM 1.60954431266576 0.0472135674150975 no 215 0.0537486868413539 69 4910486
SGTC_2277 7947813 106.88 µM 1.60848003128298 0.0473219802988166 no 216 0.0538650430848268 81 1246798
SGTC_1942 st076330 65.2 µM 1.60661182035783 0.0475127677414886 no 217 0.0540697739518366 80 24208414
SGTC_1362 1611-0397 101 µM 1.60605563414582 0.0475696860678038 no 218 0.0541308433332083 93 27816
SGTC_3312 9133330 71.43 µM 1.60033389815891 0.0481584066988703 no 219 0.0547622653290719 84 17617324
SGTC_2724 maprotiline 69.64 µM 1.59584052009638 0.0486248141099645 no 220 0.0552622020140477 79 4011 A tricyclic antidepressant.
SGTC_1943 st076331 65.2 µM 1.59398137512808 0.0488188443110785 no 221 0.055470103260496 75 24208415
SGTC_2155 5570423 76 µM 1.58955280439816 0.0492835260931313 no 222 0.0559678212660531 78 797402
SGTC_2227 7312221 64.1025 µM 1.58681969632126 0.0495720640381277 no 223 0.0562767432877236 77 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_868 0527-0199 213 µM 1.58446660779221 0.0498215613783841 no 224 0.0565437873642077 84 2849450
SGTC_2531 methyl deoxycholate 70.07 µM 1.58434434145456 0.0498345525710532 no 225 0.0565576902005741 84 16667744 Haematoxylin.
SGTC_3229 9132204 49.47 µM 1.58431653615097 0.0498375073513202 no 226 0.056560852301879 60 17682924
SGTC_3322 9139058 2.11 µM 1.58129450961373 0.0501594822491046 no 227 0.0569053571978266 90 4908926 YPR165W RHO1
SGTC_1214 0358-0031 63.7 µM 1.57950447696504 0.0503509778264651 no 228 0.0571101952189013 91 4301366
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.57749096340683 0.0505670768907995 no 229 0.0573412998846494 63 364106
SGTC_980 1473-0395 201 µM 1.57737375536651 0.050579678889252 no 230 0.0573547752808854 85 768876
SGTC_2012 4023501 200 µM 1.57588724077497 0.0507397234334682 no 231 0.0575258959882144 112 3477460
SGTC_2905 7799065 20.05 µM 1.57391118052561 0.0509530986297893 no 232 0.0577539923808207 93 1296806
SGTC_2593 nobiletin 86.24 µM 1.5640566247605 0.0520278780944555 no 233 0.0589021355482654 89 72344 An anti-infammatory.
SGTC_1085 doxorubicin 7.67 µM 1.55678851608371 0.0528320492714538 no 234 0.0597603523138855 109 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2813 7971799 71.43 µM 1.55243141568208 0.0533188430508854 no 235 0.0602795156693754 99 2234054
SGTC_1583 clindamycin 39.6 µM 1.54945920663427 0.0536529456946137 no 236 0.0606356852784848 92 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2272 7805186 180 µM 1.54559117746864 0.0540902273299539 no 237 0.0611016666337194 98 2956062 YPR165W RHO1
SGTC_270 tamoxifen 5.46 µM 1.53419191552958 0.0553953364156494 no 238 0.0624912229715682 99 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1558 st069300 45.6 µM 1.52936436976512 0.0559554861323222 no 239 0.0630870700946234 91 24208000
SGTC_1799 st045822 46.1415 µM 1.52464031599595 0.0565079434225755 no 240 0.0636744179171169 101 3674992
SGTC_647 0140-0236 81 µM 1.52132348855638 0.0568983936491961 no 241 0.0640893393354342 77 990837
SGTC_3121 9125696 49.47 µM 1.51974636301255 0.0570847934287062 no 242 0.064287367163297 63 1235365
SGTC_2798 7813637 45.45 µM 1.5195287862199 0.0571105464250807 no 243 0.0643147239365233 126 956368
SGTC_408 cantharidin 100 µM 1.51666812755656 0.0574499932047737 no 244 0.0646752476119385 88 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3060 1327-0027 12.5 µM 1.51272842230603 0.0579200758218782 no 245 0.0651743284395399 90 16000455 YPR107C YTH1
SGTC_1009 4106-0057 9.87 µM 1.51244055695218 0.0579545418772061 no 246 0.0652109119791414 109 2928005
SGTC_2336 9001819 198.65 µM 1.51216361333465 0.0579877154877075 no 247 0.0652461225593367 147 2989602
SGTC_1692 fluoroquinolonic acid 71 µM 1.51165156210111 0.0580490906996636 no 248 0.0653112635422834 81 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_479 n-linoleoylglycine 10 µM 1.51090074042693 0.0581391775786884 no 249 0.0654068710994382 105 6433346 An anti-infammatory.
SGTC_753 1322-0200 289 µM 1.50852576145852 0.0584248614054728 no 250 0.0657100092301096 81 5403907
SGTC_1699 st031318 29.054 µM 1.5070088871927 0.0586079008221552 no 251 0.0659041896117217 96 5340658
SGTC_931 2812-0076 566 µM 1.50682842585838 0.0586297068094096 no 252 0.0659273206668005 101 3450959
SGTC_778 3456-2434 196 µM 1.50599478910361 0.0587305217176109 no 253 0.0660342556803144 88 5539063
SGTC_605 1315-0399 119 µM 1.50489915453723 0.0588632278986998 no 254 0.066175002859391 112 24020461
SGTC_2303 7774051 200 µM 1.50108218328474 0.0593273881136389 no 255 0.0666671532180921 104 2953184
SGTC_1387 3342-1166 1.8 µM 1.49345667240429 0.0602632722147035 no 256 0.0676588438599498 67 3418228
SGTC_2371 9071574 200 µM 1.49103725307728 0.0605626119232483 no 257 0.0679758572807683 97 45596039
SGTC_1959 st077091 55.8 µM 1.48250076765427 0.0616280784389996 no 258 0.0691035497443211 135 821356 YKL052C ASK1
SGTC_2167 5876490 200 µM 1.47973691641477 0.0619761627175151 no 259 0.0694717348062094 81 686534
SGTC_1630 st005209 31.3 µM 1.47829326678289 0.0621585874606649 no 260 0.0696646495601946 88 3367314
SGTC_1023 4482-3888 16 µM 1.4766109415844 0.0623717002933826 no 261 0.0698899785268444 116 3303168
SGTC_3141 9094609 49.47 µM 1.47338651294084 0.0627817551505672 no 262 0.0703234224381282 130 25236309 YDL196W YDL196W
SGTC_170 4197-0004 226 µM 1.473168305307 0.0628095806172114 no 263 0.0703528295152948 105 218692
SGTC_3258 9138477 49.47 µM 1.47035630105641 0.0631690230616917 no 264 0.070732640027771 88 4970355
SGTC_284 0988-0104 32.6 µM 1.46201931523906 0.0642441104383247 no 265 0.0718679584845836 102 4666532
SGTC_2611 pyromycin 23.93 µM 1.46120515227383 0.0643498576156763 no 266 0.0719795747610956 99 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1034 k072-0165 12.7 µM 1.45750998031856 0.0648315042010151 no 267 0.0724878292202222 109 5835461
SGTC_929 2805-0021 398 µM 1.45597848724366 0.0650319449673121 no 268 0.0726992833510857 109 3098024
SGTC_2244 6635614 200 µM 1.45331254226212 0.0653820089895624 no 269 0.0730684982564697 64 836499
SGTC_2346 9031566 143.75 µM 1.45281142494176 0.0654479733725279 no 270 0.073138059471756 90 4771086
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.45228902839849 0.0655167937761463 no 271 0.0732106284373911 126 6708760
SGTC_895 0964-0006 13.7 µM 1.45210192092114 0.065541456918572 no 272 0.0732366339572305 132 6738897
SGTC_2820 7989630 71.43 µM 1.45023087480021 0.0657884806846182 no 273 0.0734970739934288 69 2984098
SGTC_1207 2099-0101 141 µM 1.44930910856927 0.0659104413648123 no 274 0.0736256392536677 108 5837381
SGTC_545 4218-0007 221 µM 1.44880750662819 0.0659768828671675 no 275 0.0736956734294233 114 2840508
SGTC_2397 5161689 200 µM 1.44782055975514 0.0661077639922499 no 276 0.0738336206225283 95 2259942
SGTC_172 1112-0046 2.638 µM 1.4453821918979 0.0664319834331767 no 277 0.0741752813264146 97 2802135 YIL048W NEO1
SGTC_2931 9014674 55.67 µM 1.44360764152818 0.0666687108727549 no 278 0.0744246871003158 96 2996810
SGTC_2086 5274770 176.623 µM 1.44296390716017 0.066754747101776 no 279 0.0745153194075303 108 689278
SGTC_224 benfluorex 43.875 µM 1.44254839811541 0.0668103262237952 no 280 0.0745738642617376 87 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3165 9101544 49.47 µM 1.44228660368906 0.0668453626258863 no 281 0.0746107688877709 101 5002184
SGTC_741 4582-0002 126 µM 1.43809324585411 0.0674085063581169 no 282 0.0752037993863399 113 2912688
SGTC_2990 9074105 71.4286 µM 1.43706490054048 0.0675471654961266 no 283 0.0753497766696389 98 6502001
SGTC_3019 9081971 49.47 µM 1.43559699266008 0.0677454757021203 no 284 0.0755585254922634 93 16451803
SGTC_2018 5133068 143 µM 1.4328031884518 0.068124152914722 no 285 0.0759570449491068 100 785362
SGTC_2837 9008476 45.46 µM 1.42982356194842 0.0685298151938401 no 286 0.0763838323943229 89 2992805
SGTC_2310 7668677 200 µM 1.42958779830781 0.0685619926997087 no 287 0.076417679790827 140 2197143
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.42221086129022 0.0695747104554902 no 288 0.077482523327385 91 17037758
SGTC_9 0092-0002 10.449 µM 1.41680117534654 0.0703246521547105 no 289 0.0782705329927709 117 759368
SGTC_2889 9059656 51.95 µM 1.416789354289 0.0703262976805801 no 290 0.0782722615542264 112 3949838
SGTC_3189 9110682 49.47 µM 1.41589583764113 0.0704507635368271 no 291 0.0784030019038426 106 17122418
SGTC_2750 bromebric acid 70.15 µM 1.41574878436236 0.0704712641112788 no 292 0.0784245347612755 103 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2768 sulfasalazine 50.2 µM 1.41550579217642 0.0705051494980412 no 293 0.0784601256775986 97 5384001 An antioxidant and salicylic acid derivative.
SGTC_1373 2887-0003 58.5 µM 1.41485529520589 0.0705959232842268 no 294 0.0785554638365888 126 776948
SGTC_2702 st077768 96.8 µM 1.41444909291628 0.0706526524411718 no 295 0.0786150421920304 90 6484119
SGTC_3243 9134147 49.47 µM 1.41295673400188 0.070861372239662 no 296 0.078834222980367 92 24282180
SGTC_3077 9117319 49.47 µM 1.41276724446564 0.0708879079095509 no 297 0.0788620861511519 114 17154678
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.41092049815892 0.0711469217972353 no 298 0.0791340286563458 149 16725076
SGTC_947 3447-0010 211 µM 1.40897610973152 0.0714204151001965 no 299 0.0794211162248394 122 748350
SGTC_3146 9095609 49.47 µM 1.40728945432633 0.0716583091634806 no 300 0.0796707875651496 93 17173999
SGTC_396 dithiazanine 1.25 µM 1.40518604285685 0.071955835731438 no 301 0.0799829816805573 91 10578 An antihelmenthic.
SGTC_1323 1348-1351 11.2 µM 1.40035577821386 0.0726426586774902 no 302 0.0807034027289587 100 6989654
SGTC_2564 betulinic acid 100 µM 1.3986846503691 0.0728814443891414 no 303 0.0809537845900434 105 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2981 9013952 38.96 µM 1.39831374291862 0.0729345243592837 no 304 0.0810094363689193 97 2996344
SGTC_643 k048-0106 28.4 µM 1.39736533935587 0.0730703834379652 no 305 0.081151868259119 124 6763920
SGTC_3015 9080845 49.47 µM 1.39704713414131 0.0731160097894267 no 306 0.0811996988465983 113 5296973
SGTC_1784 st039334 36.3 µM 1.39407749132888 0.0735428683416585 no 307 0.0816471027125792 120 3496984
SGTC_3064 1327-0027 10 µM 1.38781412402807 0.0744494137908594 no 308 0.082596826413996 74 16000455 YPR107C YTH1
SGTC_2341 7987486 176.74 µM 1.38618001920994 0.0746873278798478 no 309 0.0828459705411144 109 1258686
SGTC_2569 tetrandrine 100 µM 1.38390653234787 0.0750192960202949 no 310 0.0831935381559723 103 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_646 4092-0839 27.3 µM 1.38004011419498 0.075586442126137 no 311 0.0837871470743519 128 877796
SGTC_1108 betulinic acid 729.144 nM 1.37979886797427 0.0756219373459819 no 312 0.0838242906431849 105 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1205 4161-2785 76 µM 1.37831536594807 0.0758404882893741 no 313 0.0840529705157489 102 3498106
SGTC_587 k089-0003 57 µM 1.3708650976092 0.0769453490103451 no 314 0.0852085066499441 86 9659696
SGTC_1396 3511-0007 98.6 µM 1.36979153149588 0.0771055602592256 no 315 0.0853759931692437 114 X1396
SGTC_804 1595-0054 20.9 µM 1.36679758550598 0.0775536943133635 no 316 0.0858443799075281 115 761523 Stimulates phospholipase C.
SGTC_747 3448-8087 38.7 µM 1.36340978637048 0.0780631622650411 no 317 0.0863766992675518 109 5168703
SGTC_1553 gossypol 38.6 µM 1.3615483890631 0.0783441637458869 no 318 0.0866702262837439 98 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_502 l-744,832 89.3 µM 1.36146900053648 0.0783561654804014 no 319 0.0866827617554352 99 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2123 5259487 200 µM 1.35760658648559 0.0789417597480884 no 320 0.0872942759434759 107 2173474
SGTC_1316 1272-0050 65.9 µM 1.35618557516729 0.0791580364866265 no 321 0.0875200652163935 110 7340392
SGTC_1411 3909-8223 150 µM 1.35140668694924 0.0798886714000435 no 322 0.088282596461676 128 X1411
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.34936446831896 0.0802024531162735 no 323 0.0886099638544441 129 688803
SGTC_146 3448-8650 53.125 µM 1.3485322227149 0.0803305923686105 no 324 0.0887436317410678 138 2891488 YIL048W NEO1
SGTC_1853 st056710 91.2 µM 1.34751157861202 0.0804879501020116 no 325 0.0889077634420512 121 269167
SGTC_2811 7967822 32.47 µM 1.34652128896824 0.080640850409701 no 326 0.0890672296972099 104 2232244
SGTC_962 1254-0300 21.5 µM 1.34160807861902 0.0814026936655434 no 327 0.0898615527031078 109 7340576
SGTC_2465 5809242 33.21 µM 1.34144347847063 0.0814283102525932 no 328 0.0898882546091504 131 2731748
SGTC_1880 MG-132 525 µM 1.3406908267663 0.081545522291998 no 329 0.0900104270514825 130 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3337 9144342 33.5465 µM 1.33927709047681 0.081766030287364 no 330 0.090240241987212 125 17682949
SGTC_1008 4106-0037 6 µM 1.3369075186916 0.0821366326141227 no 331 0.0906264131431664 140 2905394
SGTC_130 0136-0219 337.655 µM 1.33556901119947 0.0823465344136387 no 332 0.0908450923037449 129 234244
SGTC_1318 1280-3875 124 µM 1.33358972160128 0.0826576621619087 no 333 0.0911691766539991 140 373245
SGTC_2699 st077704 54.6 µM 1.33254734475561 0.0828218703156538 no 334 0.0913401973293956 113 645852
SGTC_1654 st012436 41.8 µM 1.33167299559262 0.0829597978464065 no 335 0.0914838333599932 92 4323132
SGTC_235 0330-0087 5 mM 1.33118113424906 0.083037464283012 no 336 0.0915647087289375 119 46494818 YHR062C RPP1
SGTC_2081 5214970 32.255 µM 1.32514455043573 0.0839951184265607 no 337 0.0925616061689184 97 2063512
SGTC_534 k292-0788 63.4 µM 1.32264297119721 0.0843943947845742 no 338 0.0929770684476457 151 4146317
SGTC_1089 terbinafine 2.25 µM 1.31598997127624 0.0854632067050504 no 339 0.0940887043606906 113 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_355 1311-2252 105 µM 1.31505447214488 0.0856143050755203 no 340 0.0942457980465686 122 5338538
SGTC_2085 5307070 144.047 µM 1.31308562762081 0.0859329589078839 no 341 0.0945770481368424 140 2840351
SGTC_1733 st037357 54.9 µM 1.31213473841249 0.0860871760361602 no 342 0.0947373383979051 143 1272339 YGL099W LSG1
SGTC_46 0329-0187a 2.197 µM 1.31137826527 0.0862100101849664 no 343 0.0948649990967646 122 46494817
SGTC_1994 st072947 40.9 µM 1.3077721203439 0.0867973691587235 no 344 0.0954753065516682 119 5286565 YDL195W SEC31
SGTC_2885 9057732 51.95 µM 1.3046326034124 0.0873111554474326 no 345 0.0960089904298902 139 6471414
SGTC_322 k048-0136 19.3 µM 1.3037760522794 0.0874517246723493 no 346 0.0961549750157383 132 6823282
SGTC_2815 7968870 71.43 µM 1.30246381731289 0.087667404007837 no 347 0.0963789395653017 123 2977326 YHR190W ERG9
SGTC_2904 7225135 42.03 µM 1.30054319149028 0.0879837938042915 no 348 0.0967074314878253 158 4446116
SGTC_3292 9120825 59.784 µM 1.30051615762721 0.0879882532330645 no 349 0.0967120610533169 139 24824900
SGTC_76 0433-0009 400.328 µM 1.29863781647447 0.0882985118566528 no 350 0.0970341267965324 126 2841569
SGTC_1625 st003711 30.1 µM 1.29822900092872 0.0883661466622876 no 351 0.097104327678815 121 24207034 YER133W GLC7
SGTC_2694 st077685 81.9 µM 1.29675538676938 0.0886102630845125 no 352 0.097357682714018 109 2838096
SGTC_1948 st076329 66.6 µM 1.29547742925072 0.0888223737690661 no 353 0.0975777913084026 111 24208413
SGTC_1720 st037298 9.481 µM 1.29386688017177 0.089090224934858 no 354 0.0978557031615617 133 597396
SGTC_1856 st057054 55.7 µM 1.29273951419636 0.0892780750583358 no 355 0.0980505831875712 136 1266018
SGTC_1221 2958-7315 257 µM 1.28955076661737 0.089811003364457 no 356 0.098603339573581 136 4562705
SGTC_2258 7960471 200 µM 1.28808608624728 0.0900565831754908 no 357 0.0988579990784753 111 2974708
SGTC_3018 9082602 49.47 µM 1.28660590403796 0.0903052686762998 no 358 0.0991158424065083 139 17332089
SGTC_1618 st003135 44.5 µM 1.28120262641766 0.0912174030676343 no 359 0.100061251927885 131 1270615
SGTC_2332 7982454 138.89 µM 1.27957535951883 0.0914934381398018 no 360 0.100347260186874 143 2981748
SGTC_649 1123-0311 367 µM 1.27922605734178 0.0915527712767793 no 361 0.100408731202192 144 693629 YIL048W NEO1
SGTC_1225 1216-0074 20.6 µM 1.27863432689167 0.0916533488036469 no 362 0.100512928007367 128 4241466
SGTC_1944 st076371 56.9 µM 1.27793776242118 0.0917718500453451 no 363 0.100635685920015 121 24208455
SGTC_1842 st055362 61.2 µM 1.27696212143815 0.091938019225921 no 364 0.10080781023689 115 676032
SGTC_324 1315-0088 19.6 µM 1.27326370882723 0.0925699487421139 no 365 0.101462240043894 132 6787421
SGTC_2873 9040596 71.43 µM 1.26284074998447 0.0943681478960996 no 366 0.103323208345525 150 6463863
SGTC_1166 k206-0078 225 µM 1.26093619208245 0.0946994926902751 no 367 0.103665918646891 140 5404595
SGTC_1209 2323-2347 50.3 µM 1.25879361294287 0.0950732711465613 no 368 0.104052443968324 123 5412760
SGTC_1185 1319-0113 81.3 µM 1.25452678167464 0.0958208654605312 no 369 0.104825298789993 136 4672763
SGTC_407 eburnamonine 100 µM 1.25431971797218 0.0958572549326285 no 370 0.104862909885881 123 3195
SGTC_2251 lansoprazole 556 µM 1.2534170361143 0.0960160114137797 no 371 0.105026987357996 116 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3055 9094636 49.47 µM 1.25179853861795 0.0963011437920544 no 372 0.105321641397557 158 25236176
SGTC_1156 4092-0367 4.88 µM 1.25137480915362 0.0963758953378862 no 373 0.10539888175349 154 1357585
SGTC_878 0828-0289 13.7 µM 1.25091198975341 0.0964575915838656 no 374 0.105483294505681 142 745350 YLR208W SEC13
SGTC_3156 9099931 49.47 µM 1.24994649113803 0.0966281838520251 no 375 0.105659547338407 130 18111053
SGTC_433 pimozide 108 µM 1.24127511535111 0.0981702567147902 no 376 0.10725206710395 118 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_313 3474-0040 5.03 µM 1.23771197104544 0.0988091070932283 no 377 0.107911439386009 156 1043375 YIL048W NEO1
SGTC_3161 9100388 49.47 µM 1.23686654120688 0.0989611331395939 no 378 0.108068316739742 140 25236368
SGTC_831 k061-1017 217 µM 1.23683717647713 0.098966416608155 no 379 0.108073768586971 149 1240153
SGTC_428 3448-4153 16.5 µM 1.23045189447225 0.100120199193844 no 380 0.109263965288312 129 3834874
SGTC_2075 5212009 200 µM 1.23030478205994 0.100146896782291 no 381 0.1092914971253 134 780898
SGTC_386 1509-0011 3.07 µM 1.22896823590789 0.100389687930669 no 382 0.109541857805716 130 3107280
SGTC_1587 estradiol valerate 56.1 µM 1.22884721813653 0.100411692679989 no 383 0.109564547067692 150 13791 A steroid.
SGTC_201 4262-0159 12.803 µM 1.22134104383966 0.101783433434686 no 384 0.110978459659297 123 1341029
SGTC_1975 st070967 30.8 µM 1.22107031510896 0.101833162289828 no 385 0.111029698975827 183 261391
SGTC_597 k018-0003 82.8 µM 1.21472022713165 0.103004656046377 no 386 0.112236407591038 141 6786234
SGTC_800 3448-7362 155 µM 1.21318739970341 0.103288900194711 no 387 0.112529090231567 187 15991913
SGTC_3110 9122132 49.47 µM 1.21163275521611 0.103577771321924 no 388 0.112826495155088 113 918317
SGTC_1854 st056233 32.9 µM 1.2105021075641 0.103788226804335 no 389 0.113043141271168 146 5393174
SGTC_3191 9110352 49.47 µM 1.20933405921611 0.104005969520849 no 390 0.113267265426968 129 17122424
SGTC_1731 st035964 63 µM 1.20715916285017 0.104412286905529 no 391 0.113685427008047 152 6739575
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.20441834894899 0.104925966321757 no 392 0.114213961753378 143 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1760 st045453 10.4495 µM 1.20396385655641 0.10501132317838 no 393 0.114301774313148 149 3323419 YIL048W NEO1
SGTC_2824 7998404 51.95 µM 1.20381582702534 0.10503913501008 no 394 0.114330385502567 145 837851
SGTC_2457 5731572 11.68 µM 1.20234793433363 0.105315211719433 no 395 0.114614376236141 150 2865357
SGTC_57 miconazole 162.5 nM 1.19943380460986 0.105864846999983 no 396 0.115179654824427 157 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_83 0170-0301 39.027 µM 1.19877332185882 0.105989708626475 no 397 0.115308049356557 120 3089716
SGTC_2301 7769476 200 µM 1.19765987414446 0.106200442321863 no 398 0.115524728251519 143 977820
SGTC_1889 st059080 5.18 µM 1.19645782195332 0.106428285060314 no 399 0.115758974307556 120 176925 Isolated from Daphnopsis sellowiana.
SGTC_2934 9036370 36.88 µM 1.19466647700731 0.10676847974625 no 400 0.116108682503461 119 6462800
SGTC_3022 9087993 49.47 µM 1.19437608881329 0.106823701258041 no 401 0.116165442940302 143 17173644
SGTC_3280 9140961 49.47 µM 1.19204583548125 0.107267578937181 no 402 0.116621636699334 146 4901226
SGTC_2620 irigenin 100 µM 1.19102026872105 0.107463354590294 no 403 0.116822814008349 160 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2438 5259590 200 µM 1.18787065512537 0.108066209929351 no 404 0.117442186243443 146 1201127
SGTC_1822 st052468 42 µM 1.18754548534495 0.108128587809232 no 405 0.117506263128142 136 2873678
SGTC_1648 st011736 69.8 µM 1.18465729350793 0.108683772429423 no 406 0.118076487135259 150 2855514
SGTC_1212 0520-0165 585 µM 1.18251410796196 0.10909707073368 no 407 0.118500885503597 145 5403258
SGTC_1815 st051655 58.2 µM 1.18154302554138 0.109284708542257 no 408 0.118693535887331 159 5984156
SGTC_2159 5658611 73.75 µM 1.17963609243225 0.109653850929965 no 409 0.119072490787679 141 793844
SGTC_1798 st045719 60.953 µM 1.17926391846463 0.109726000316149 no 410 0.119146550501493 144 3980186
SGTC_2853 9015042 58.44 µM 1.17413963653071 0.110722856514224 no 411 0.120169549753489 121 6457456
SGTC_2228 7354201 200 µM 1.17212584906021 0.111116381263027 no 412 0.120573266639824 182 753451
SGTC_1507 4075-3230 155 µM 1.17025095887183 0.111483662768483 no 413 0.120949995510554 130 659771
SGTC_1128 3448-9350 235 µM 1.16915678301013 0.111698407319673 no 414 0.121170234799761 116 619386
SGTC_163 TUB2.036 7.546 µM 1.16695428306191 0.112131570133545 no 415 0.121614416187794 192 15992207 YJR013W GPI14
SGTC_969 1313-0238 134 µM 1.16389738961507 0.11273475320263 no 416 0.122232798801608 186 5212874
SGTC_530 4358-1714 28 µM 1.16324368543081 0.112864041580525 no 417 0.122365323390754 162 1564641
SGTC_3130 9127414 49.47 µM 1.16260940615378 0.112989589281612 no 418 0.122494006357167 146 1494646
SGTC_288 1315-0019 35.1 µM 1.16241593738527 0.113027903851306 no 419 0.122533276311581 180 6811474
SGTC_2484 5809818 12.04 µM 1.15591444582908 0.114320855058042 no 420 0.123858076599668 144 2870548
SGTC_225 nsc-122657 1.016 µM 1.15568999001978 0.114365679868202 no 421 0.123903992016129 136 275685
SGTC_1007 4101-0031 70 µM 1.15562145079802 0.114379369945194 no 422 0.123918014998151 166 1146276
SGTC_972 1319-0219 195 µM 1.15560644114521 0.114382368140541 no 423 0.123921086090109 166 23903702
SGTC_975 1335-0046 28.5 µM 1.15529062213345 0.114445466325151 no 424 0.123985717474253 148 16486740
SGTC_311 1315-0136 58 µM 1.15264370620118 0.114975273806112 no 425 0.124528328053694 133 6759207
SGTC_278 4092-0821 23.9 µM 1.15248637290665 0.115006820518537 no 426 0.12456063314464 144 877900
SGTC_3266 9136860 49.47 µM 1.15233570650613 0.115037036229433 no 427 0.124591574819916 165 4871271 YPR165W RHO1
SGTC_850 0388-0143 75.9 µM 1.14900833130898 0.11570577118285 no 428 0.125276272646461 143 67273
SGTC_1468 k284-1086 134 µM 1.14881511706147 0.115744687978607 no 429 0.125316112272905 162 15996457
SGTC_2718 lomofungin 53.02 µM 1.14876101670681 0.115755586420768 no 430 0.125327269028494 143 5351222 A RNA synthesis inhibitor.
SGTC_2437 5741531 144.16 µM 1.14785742571819 0.115937721335964 no 431 0.125513713089978 170 2262990
SGTC_2333 9017922 200 µM 1.14781890741446 0.115945489907631 no 432 0.125521665132275 138 3163164
SGTC_1945 st075991 56.6 µM 1.14589088355736 0.116334816111433 no 433 0.12592015189865 147 1084980
SGTC_1210 3013-0140 750 nM 1.14520859413085 0.11647281287765 no 434 0.126061379575515 155 905973
SGTC_2455 5377712 9.75 µM 1.14424692865046 0.116667512073886 no 435 0.126260622999166 141 2243908
SGTC_549 1661-1316 519 µM 1.14393888835523 0.116729926813965 no 436 0.12632449095612 165 2857282
SGTC_2093 5331342 194.4 µM 1.14211240712342 0.117100492507557 no 437 0.126703649433722 160 33839
SGTC_2014 4013930 200 µM 1.14164022452974 0.117196426727324 no 438 0.126801798408097 171 64556
SGTC_2109 5483026 200 µM 1.13993686050612 0.117542965027055 no 439 0.127156303484587 209 759335
SGTC_2468 5987765 72.9 µM 1.13946992066512 0.11763808745113 no 440 0.127253603581916 138 26772094
SGTC_2411 st077133 39.94 µM 1.13900947331142 0.117731940605742 no 441 0.127349601494832 166 1403142 YNL221C POP1
SGTC_2871 9038510 12.99 µM 1.13633544169991 0.118278036985301 no 442 0.12790810160937 191 4945164
SGTC_2247 cerulenin 830 nM 1.1353731296964 0.118474999918606 no 443 0.128109506592994 158 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_818 4072-2707 53.5 µM 1.13500765187715 0.118549865452486 no 444 0.128186056158645 133 882871
SGTC_3298 9116858 71.43 µM 1.13426226516919 0.118702656229913 no 445 0.128342276332597 172 2506942
SGTC_2917 7979103 53.79 µM 1.13303731152012 0.118954051629709 no 446 0.128599292463244 136 2980565
SGTC_2157 5649910 96.377 µM 1.13282371490551 0.118997926210076 no 447 0.128644145215446 145 2858091
SGTC_79 0052-0007 94.094 µM 1.13189207165226 0.11918942735133 no 448 0.128839906159903 155 2801472
SGTC_264 promethazine 12.5 mM 1.13055392123282 0.119464867315667 no 449 0.129121445561883 196 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1370 2001-0092 44.6 µM 1.13053217489197 0.119469347207831 no 450 0.129126024390394 164 790957
SGTC_1268 0828-0275 2.46 µM 1.1276033589808 0.120073786211844 no 451 0.129743733745896 164 745337
SGTC_2278 7948257 134.34 µM 1.12546168884029 0.120517138804392 no 452 0.130196721457146 143 1247028
SGTC_841 0251-0215 91.2 µM 1.12465487691748 0.120684457562899 no 453 0.130367654853893 159 3888614
SGTC_85 0868-0259 160.055 µM 1.12430056694587 0.120757986940172 no 454 0.13044276897341 147 83173
SGTC_111 0083-0039 52.457 µM 1.12365011853353 0.12089305552154 no 455 0.13058074268566 131 759313
SGTC_1122 capsaicin 818.572 nM 1.12347185280173 0.120930091768565 no 456 0.130618574187412 158 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2520 obtusaquinone 4.71 µM 1.12317917254878 0.120990915935189 no 457 0.130680703139053 166 5967872
SGTC_3139 9095020 49.47 µM 1.12203155085771 0.12122961981131 no 458 0.130924512610901 120 25236292
SGTC_1691 st019933 84.6 µM 1.1214010896058 0.121360895829486 no 459 0.131058586279818 171 6176082
SGTC_1735 st034310 56.75 µM 1.1176099672916 0.122152399262471 no 460 0.131866804974576 171 871153
SGTC_1014 4130-3005 69.3 µM 1.11642844805585 0.122399813808918 no 461 0.132119391004517 157 743608
SGTC_3315 9136395 68.55 µM 1.11553762351462 0.122586588199829 no 462 0.132310052559247 201 16876844
SGTC_779 1360-0071 233 µM 1.11509843933432 0.122678743137703 no 463 0.132404120113208 166 7566
SGTC_1652 st011932 78 µM 1.11504509094473 0.122689940651349 no 464 0.132415549784713 165 1551076
SGTC_429 1112-0049 25.5 µM 1.11462099392823 0.122778981627185 no 465 0.13250643500128 144 2836170
SGTC_473 2-arachidonoylglycerol 10 µM 1.11264706447344 0.123194012870715 no 466 0.132930019327833 169 5282280 An endocannabinoid.
SGTC_1561 5-methoxyflavone 52.9 µM 1.11234475946124 0.123257661140288 no 467 0.132994973006014 144 94525
SGTC_3175 9106517 49.47 µM 1.11137848954671 0.12346125723757 no 468 0.133202733625642 160 41468073
SGTC_2404 5161160 200 µM 1.11110744114315 0.123518410268615 no 469 0.133261052653552 196 2831543
SGTC_1575 cyproterone acetate 48 µM 1.10894265600479 0.123975540033566 no 470 0.133727460332948 170 9880 An androgen receptor antagonist and liver toxin.
SGTC_2836 9010338 19.48 µM 1.10844941683796 0.124079860945833 no 471 0.133833886576919 138 2994051
SGTC_1651 st011928 86.1 µM 1.10429526938012 0.124960907384819 no 472 0.134732537126449 153 720198
SGTC_812 4251-0442 148 µM 1.10375460121749 0.125075897439296 no 473 0.134849801577951 165 5723007
SGTC_2630 antimycin a 100 µM 1.1028299588966 0.125272722878449 no 474 0.13505050765398 172 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1451 4152-0210 104 µM 1.09987200856834 0.125903823626683 no 475 0.135693946121275 165 659563
SGTC_1107 amlodipine 47 µM 1.09662238864878 0.126599706392456 no 476 0.136403248146558 141 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2222 6885208 172.143 µM 1.09615111683499 0.126700847859564 no 477 0.136506323936236 150 609514
SGTC_3325 9138760 55.175 µM 1.09561625916995 0.126815703884992 no 478 0.1366233716434 142 43844959
SGTC_832 4083-0019 164 µM 1.08335860510191 0.129467810888271 no 479 0.139324640930057 195 1990758
SGTC_1301 naphtanilide LB 4.81 µM 1.08205905298954 0.129751223028382 no 480 0.139613144433583 183 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1292 0kpi-0043 232 µM 1.08134597634794 0.129906916392963 no 481 0.139771621550739 163 3333905
SGTC_1466 k213-0079 57.5 µM 1.08108614499365 0.129963680185456 no 482 0.139829397937899 192 3657981
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.08096992688081 0.129989075213876 no 483 0.139855245579643 161 229346 A bile salt which induces apoptosis.
SGTC_1701 st028638 40.4 µM 1.07875150008197 0.130474486278987 no 484 0.140349260388944 151 3490878
SGTC_3197 9113331 49.47 µM 1.07734449111525 0.13078300096404 no 485 0.140663196397207 158 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1084 voriconazole 435 nM 1.07291903867029 0.131756654917369 no 486 0.141653721528099 185 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2436 5633522 8.09 µM 1.07043555007055 0.132305238456529 no 487 0.142211652326483 172 5724242
SGTC_590 k048-0076 22.4 µM 1.0689001462694 0.132645183835687 no 488 0.142557333026381 165 6832814
SGTC_686 1319-0111 510 µM 1.06788266295692 0.132870790460109 no 489 0.142786721943911 171 4562600
SGTC_1462 k081-0014 26.5 µM 1.06667721312561 0.133138416670263 no 490 0.14305881015587 138 3270634
SGTC_375 3970-0961 9.27 µM 1.06663124499835 0.133148629555911 no 491 0.143069192784809 168 2898222
SGTC_446 go6976 132 µM 1.06602068109678 0.133284331628437 no 492 0.143207146591934 162 3501 A protein kinase C inhibitor.
SGTC_445 e6 berbamine 66 µM 1.065186600058 0.133469865681481 no 493 0.143395748121026 186 6610268 A calcium/calmodulin antagonist.
SGTC_591 4299-0174 154 µM 1.06440973508043 0.133642832226672 no 494 0.143571562796949 169 5509088
SGTC_1605 st000082 49.1 µM 1.06415995274909 0.133698478206784 no 495 0.143628122694858 180 1114022
SGTC_1470 k295-0292 231 µM 1.06410734827231 0.13371019935135 no 496 0.143640036198061 186 5045612
SGTC_1111 tnp00062 510.699 nM 1.05589506991829 0.135548698882904 no 497 0.145508078391544 165 676306
SGTC_2895 9054447 58.44 µM 1.05568311475669 0.135596377895554 no 498 0.145556507009241 176 2697450
SGTC_1852 st056254 31.4 µM 1.05567414057883 0.13559839687763 no 499 0.145558557715213 167 442583
SGTC_1563 conessine 56.1 µM 1.05497627705802 0.135755463075141 no 500 0.145718087297776 131 441082 An anti-amoebic, histamine inhibitor.
SGTC_1012 4112-3522 18 µM 1.05440854661474 0.135883332468567 no 501 0.14584795550698 163 3112398
SGTC_2321 7390090 138.78 µM 1.05384389999231 0.136010589072253 no 502 0.145977195425358 143 649046
SGTC_2607 solasodine 47.35 µM 1.05285726954015 0.136233145589368 no 503 0.146203206341159 188 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1087 pterostilbene 9.05 µM 1.04443783323225 0.138142473751607 no 504 0.148141433649672 189 5281727 Similar to reservatol, lowers cholesterol.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.043408092586 0.138377240684653 no 505 0.148379663542636 190 5282309
SGTC_303 1348-1668 34.2 µM 1.04315766922456 0.138434374905402 no 506 0.148437637553038 165 5380509
SGTC_2353 9059630 146.67 µM 1.04266525133358 0.138546767185452 no 507 0.148551678439649 171 4779114
SGTC_2487 5918373 44.05 µM 1.04138613614981 0.138839010214959 no 508 0.148848187137961 198 2876279
SGTC_3147 9097027 49.47 µM 1.03993545662397 0.139170958719743 no 509 0.149184944067121 201 25236841
SGTC_1554 st069299 38.7 µM 1.03950907432473 0.139268627322344 no 510 0.149284020007701 151 24207999
SGTC_1058 3448-5425 97.3 µM 1.0372948880215 0.139776566353065 no 511 0.149799223731719 188 7279705
SGTC_1713 st033146 12.748 µM 1.03727181218318 0.139781866621598 no 512 0.149804599326381 166 674619
SGTC_2924 9010168 62.78 µM 1.03725364519266 0.139786039477418 no 513 0.149808831478852 166 2993929
SGTC_725 1497-0963 19 µM 1.03711666479969 0.139817505831775 no 514 0.149840744775398 169 3549977
SGTC_2356 9061756 188.97 µM 1.03700234426118 0.139843770579327 no 515 0.149867382315505 164 20104043
SGTC_1127 asiatic acid 681.4 nM 1.03612090681101 0.140046390387301 no 516 0.150072869877875 172 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3286 9117135 37.221 µM 1.03607279941183 0.140057454779148 no 517 0.150084090452539 193 3438150
SGTC_2985 9022375 71.43 µM 1.03589385963326 0.140098614988409 no 518 0.150125831293709 178 4939335
SGTC_1920 st075728 45.7 µM 1.03409214994062 0.140513507044858 no 519 0.150546542883386 162 3400306
SGTC_714 4296-0578 26.1 µM 1.0251583223421 0.14258307556033 no 520 0.152644245028045 187 1589775
SGTC_2568 diosmetin 100 µM 1.02342965769989 0.142985897970589 no 521 0.153052371411678 208 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_481 bay k-8644 50 µM 1.02194471597179 0.143332540246037 no 522 0.153403533441398 182 2303 A calcium channel antagonist.
SGTC_2958 9077254 16.72 µM 1.01527575575166 0.144896324303133 no 523 0.154987198928725 175 16457351
SGTC_535 2293-4129 48.2 µM 1.01305670918114 0.145419199295767 no 524 0.155516537267379 205 396118 YIL048W NEO1
SGTC_2838 9002687 71.43 µM 1.00959346771401 0.146237777668267 no 525 0.156345050269754 192 6457060
SGTC_1897 st060201 15 µM 1.00929131281146 0.146309342062742 no 526 0.15641747257283 179 611878
SGTC_134 0269-0018 6.916 µM 1.00888751610647 0.14640501669103 no 527 0.15651429147926 180 4378915
SGTC_875 0709-0210 25.7 µM 1.00858348178596 0.146477081570812 no 528 0.156587216252401 190 6251364
SGTC_82 0054-0107 293.755 µM 1.00685484910493 0.146887269760228 no 529 0.157002266058501 177 3104697
SGTC_2146 5545642 200 µM 1.00536180763773 0.14724217392703 no 530 0.157361331641874 173 825326
SGTC_1141 3253-0389 52.6 µM 1.00488080648499 0.147356632859745 no 531 0.157477123784816 194 5402031
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.0044759323548 0.147453022828302 no 532 0.157574633145754 192 165506
SGTC_3239 9133757 49.47 µM 1.00443388083091 0.147463036620384 no 533 0.157584763054022 184 17036923
SGTC_2376 9072922 81.32 µM 1.00289817394027 0.147829048964974 no 534 0.157954996887853 175 17087968
SGTC_6 0844-0013 19.835 µM 1.00219117506123 0.147997755678443 no 535 0.158125634594624 212 1584900
SGTC_2299 7976368 114.88 µM 1.00174303344627 0.148104759610409 no 536 0.158233858438982 159 2979718
SGTC_814 3342-0569 96 µM 1.00095964920573 0.148291934615428 no 537 0.158423158336483 190 4346283
SGTC_2165 5727197 32.143 µM 1.00094322045945 0.148295861650279 no 538 0.158427129829908 193 1361712
SGTC_2878 9043973 25.97 µM 1.00073824389065 0.148344863941921 no 539 0.158476686459871 174 6465167
SGTC_110 0850-0284 111.64 µM 1.00037875270067 0.148430831097864 no 540 0.15856362422185 156 3906265
SGTC_701 4424-0219 185 µM 1.00030152574772 0.148449303161356 no 541 0.15858230452754 181 2911779
SGTC_1190 1486-1332 13 µM 0.999651583629833 0.14860482497992 no 542 0.158739575179873 185 4150046
SGTC_1163 k060-0048 49.9 µM 0.999079422497008 0.148741825049205 no 543 0.158878109267428 174 6809982
SGTC_3041 9091929 49.47 µM 0.998946420327093 0.148773683597643 no 544 0.158910323665621 168 25236887
SGTC_1917 st066507 28.5 µM 0.99890844286928 0.148782781328897 no 545 0.158919522954895 198 3156428
SGTC_852 0418-0143 439 µM 0.997365645353703 0.149152682236058 no 546 0.15929353025006 188 5369229
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.99695354588055 0.149251590996425 no 547 0.159393529491173 192 7104
SGTC_1609 st001574 46.4 µM 0.994940714555893 0.149735323653163 no 548 0.159882549668693 202 3960012
SGTC_232 clozapine 119 µM 0.992703715343131 0.150274155143674 no 549 0.160427181907842 177 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_107 0358-0022 2.6945 µM 0.990995277259911 0.150686540059851 no 550 0.160843943186082 176 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3311 9131146 2.8755 µM 0.988115576805661 0.151383349863584 no 551 0.161548023932932 215 4900406 YPR165W RHO1
SGTC_2876 9059903 25.97 µM 0.983786552019577 0.152434882788545 no 552 0.162610236423764 174 6916095
SGTC_2354 9060492 162 µM 0.983259399356873 0.152563260018611 no 553 0.162739893479732 208 6471895
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.982150795388192 0.152833471795051 no 554 0.163012782072753 210 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_737 1950-0117 57.9 µM 0.979476605248012 0.153486585863603 no 555 0.163672271249197 190 5393513
SGTC_1795 st049545 62.3 µM 0.977730817060928 0.153913953341182 no 556 0.164103737919247 163 5291882
SGTC_195 4234-0266 16.654 µM 0.977272854351129 0.154026192483973 no 557 0.164217044166794 204 2303354
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.97674435908489 0.154155785287701 no 558 0.164347864176374 182 75037 A free radical scavenger.
SGTC_472 calcifediol 10 µM 0.976540371717255 0.154205824500767 no 559 0.164398375845446 167 5283731 A vitamin D metabolite.
SGTC_1911 st060208 74.3 µM 0.975000146791763 0.154583996828723 no 560 0.164780093573207 199 688783
SGTC_1519 esterone 74 µM 0.974931797253519 0.154600792922453 no 561 0.164797046100929 186 698 A steroid.
SGTC_775 4577-0580 57.3 µM 0.971683597061615 0.155400390464707 no 562 0.165603989752925 189 2006902
SGTC_205 1486-1330 71.903 µM 0.970167561896502 0.155774519686019 no 563 0.165981488399248 189 4118834
SGTC_1793 st048256 72.231 µM 0.96756125233037 0.156419095375433 no 564 0.166631768289214 181 672022
SGTC_2481 5478948 45.16 µM 0.965793075106112 0.156857388190656 no 565 0.167073867168995 182 77792
SGTC_2242 6630449 61.2675 µM 0.964668725680362 0.157136509940406 no 566 0.167355382237874 178 691249 YDR170C SEC7
SGTC_713 1488-1073 324 µM 0.964466047799134 0.15718685981168 no 567 0.167406161308375 196 3312542
SGTC_1569 carminic acid 40.6 µM 0.963818729074559 0.157347739788294 no 568 0.167568407516591 185 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2031 5180455 200 µM 0.963074704125916 0.157532788097825 no 569 0.1677550175851 189 29949
SGTC_489 paxilline 115 µM 0.961466075163097 0.157933362881233 no 570 0.168158937580319 187 105008 A toxic potassium channel blocker.
SGTC_703 3875-0075 71.8 µM 0.960911607750091 0.158071589145708 no 571 0.168298306917063 215 2850814
SGTC_3092 9117248 49.47 µM 0.958617305406008 0.158644392436917 no 572 0.168875785658423 210 17141857
SGTC_2957 9076800 11.52 µM 0.956251438529019 0.159236486337215 no 573 0.169472608867297 174 16459615
SGTC_1377 2944-0135 198 µM 0.95483632520441 0.159591330651771 no 574 0.169830237210397 179 1894137
SGTC_1611 st001856 99.4 µM 0.953088769063383 0.160030249709214 no 575 0.170272548002596 213 647478
SGTC_2217 6934799 96.0675 µM 0.951459037100021 0.160440286504258 no 576 0.170685701630365 191 675606
SGTC_84 0443-0269 128.823 µM 0.94772499866446 0.161382347808947 no 577 0.171634735537154 189 6150058
SGTC_1330 1469-0054 61.8 µM 0.94754349986711 0.161428229927111 no 578 0.171680950571273 198 7102664
SGTC_2875 9039966 71.43 µM 0.934323268284504 0.164793118071593 no 579 0.175068582621728 192 6463691
SGTC_1215 3852-0577 11.2 µM 0.933822038073949 0.164921581650544 no 580 0.175197849759995 192 2884876
SGTC_220 paclitaxel 373.376 µM 0.933220271640839 0.165075897962296 no 581 0.175353125107544 176 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2582 agaric acid 100 µM 0.93285902372028 0.16516858086291 no 582 0.17544638073989 221 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_80 0159-0065 512.242 µM 0.932782076697829 0.16518832698305 no 583 0.17546624856396 182 1548079
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.931697738424939 0.165466751990602 no 584 0.175746377793548 219 65057 A dermal irritant. YDR527W RBA50
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.929533635405502 0.166023334630638 no 585 0.176306301147907 194 5377381
SGTC_1559 coumarin 343 70.1 µM 0.929376230956787 0.166063864402171 no 586 0.17634707075296 195 108770 A hepatotoxic, DNA x-linker.
SGTC_1921 5740136 50 µM 0.929060713825377 0.166145125555575 no 587 0.176428811364633 163 1774243
SGTC_3179 9107801 49.47 µM 0.928350069808482 0.166328245350949 no 588 0.176613004754299 173 4818259
SGTC_1422 4031-0024 15.5 µM 0.927698137773638 0.166496350739811 no 589 0.176782087364151 220 782427
SGTC_2583 asiatic acid 100 µM 0.926344799352138 0.166845668872034 no 590 0.177133410627604 234 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_739 1486-1183 203 µM 0.923419187410933 0.167602430255393 no 591 0.177894398189145 189 4346692
SGTC_2877 9040724 71.43 µM 0.922583335385822 0.167819043625707 no 592 0.178112191694811 185 6463895
SGTC_1067 clotrimazole 1.36 µM 0.918227314667832 0.168950834227481 no 593 0.17924993566261 206 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_189 3970-0742 2.116 µM 0.917213105355371 0.16921505032925 no 594 0.179515490364646 203 2891807
SGTC_2941 9056145 11.23 µM 0.91672355303309 0.169342680623041 no 595 0.179643760356311 186 2119517
SGTC_1908 st060353 56.5 µM 0.916458063289021 0.169411921803929 no 596 0.179713346699025 223 4227716
SGTC_2786 7743617 45.45 µM 0.915717900871916 0.169605056142871 no 597 0.179907436804483 185 583674
SGTC_621 3584-0052 32.1 µM 0.915630462445141 0.169627881220792 no 598 0.179930374157434 207 2273927
SGTC_3063 1327-0034 4 µM 0.912934018266137 0.170332732883876 no 599 0.180638622375581 214 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_555 4296-0685 37 µM 0.911844710529427 0.170618009680997 no 600 0.180925235111367 217 2908540 YHR072W ERG7
SGTC_521 r062-0005 13.8 µM 0.910854693679656 0.170877548539843 no 601 0.181185970037633 186 2832033
SGTC_2671 danthron 100 µM 0.90711149738555 0.171861131666111 no 602 0.182173919337882 204 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_835 0312-0010 67.2 µM 0.905699174069005 0.172233179132206 no 603 0.182547549899186 225 1626196
SGTC_2300 7976697 71.57 µM 0.904784579902875 0.172474384070583 no 604 0.182789761194219 178 2236109
SGTC_689 0833-0039 98 µM 0.904605426193188 0.172521657307976 no 605 0.182837229825223 233 5374726
SGTC_1807 st050092 58.9 µM 0.904526640502512 0.172542449080945 no 606 0.182858107345648 207 5008496
SGTC_3014 9081533 49.47 µM 0.904481907567654 0.172554254943747 no 607 0.182869961845193 234 21367265
SGTC_2449 5812982 45.77 µM 0.903713308637865 0.172757183112377 no 608 0.183073720148869 192 776185
SGTC_1831 st055328 12 µM 0.898768328994074 0.174066409352679 no 609 0.184388036463079 200 1103068
SGTC_1131 3454-3128 32.3 µM 0.896155253963148 0.174760783997539 no 610 0.185084925054221 196 710982
SGTC_2980 9014342 25.29 µM 0.895363452885506 0.17497153662077 no 611 0.185296415378148 226 2996599
SGTC_1489 4065-0444 182 µM 0.89446409163871 0.175211113916872 no 612 0.185536816991982 208 2877968
SGTC_996 3970-0799 1.8 µM 0.894394549955531 0.175229647512852 no 613 0.18555541372447 237 6615648 YGL040C HEM2
SGTC_3223 9129970 49.47 µM 0.893604601415257 0.175440264443824 no 614 0.185766741770222 222 17248386
SGTC_1744 st037937 38.9 µM 0.893402426100341 0.175494194424527 no 615 0.185820851954568 214 1016152
SGTC_2040 5100729 123 µM 0.891780709441136 0.175927165175928 no 616 0.18625524168366 205 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2586 curcumin 80 µM 0.89163029494552 0.175967357538578 no 617 0.186295563267413 205 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2952 9073731 13.78 µM 0.891591955722429 0.175977603119035 no 618 0.186305841720195 218 16457353
SGTC_3198 9112019 49.47 µM 0.890758658120288 0.176200382683999 no 619 0.186529329244056 246 45595555
SGTC_783 0848-0141 92.7 µM 0.888367907144818 0.176840532799944 no 620 0.187171441287809 240 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1015 4130-4525 82 µM 0.887094841523991 0.177182009288785 no 621 0.187513920547903 218 1363237
SGTC_2355 9061122 103.12 µM 0.886451990384066 0.177354600454888 no 622 0.187687006985024 223 5302957
SGTC_2771 fluoxetine 41.05 µM 0.886218242362715 0.177417382882278 no 623 0.187749967652169 206 3386 A selective serotonin reuptake inhibitor.
SGTC_754 3474-0146 171 µM 0.884488368803791 0.177882446010515 no 624 0.188216319225782 212 24762078
SGTC_1788 fluconazole 20 µM 0.882988639547716 0.178286258264752 no 625 0.188621204781718 220 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2982 9019404 25.97 µM 0.881337250452953 0.178731573647263 no 626 0.189067654954581 195 22333232
SGTC_3196 9111891 49.47 µM 0.879434474912472 0.179245545656254 no 627 0.189582873262258 226 18891510
SGTC_1309 pyrazolanthrone 13.4 µM 0.877795886673905 0.179688900309935 no 628 0.190027248547865 219 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2383 9036125 200 µM 0.877400634544081 0.179795947182278 no 629 0.190134534312972 205 79580
SGTC_2799 7812892 81.82 µM 0.875307246859402 0.180363571018147 no 630 0.190703376044929 238 20205235
SGTC_3220 9131269 49.47 µM 0.87487690309036 0.180480398274049 no 631 0.190820443785597 233 17722206
SGTC_585 0kpi-0023 191 µM 0.872202134742259 0.181207593028645 no 632 0.191549057572863 180 64601
SGTC_3203 9113543 49.47 µM 0.866998167209107 0.182627656076474 no 633 0.192971506954383 212 17018012
SGTC_34 0469-0683 81.75 µM 0.866713523139916 0.182705529919138 no 634 0.193049497020221 186 3690923
SGTC_2763 lisinopril 49.32 µM 0.864785260239624 0.183233616088679 no 635 0.193578331372076 223 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_320 4092-0846 5.34 µM 0.864571462675836 0.183292226597229 no 636 0.193637020631476 219 1359356
SGTC_2180 6301957 200 µM 0.863980130230963 0.183454395470725 no 637 0.193799402943984 213 845462
SGTC_1904 st060225 78 µM 0.86244811094986 0.183874957129681 no 638 0.194220487672441 205 66595
SGTC_2930 9013230 14.89 µM 0.862393264713928 0.18389002434672 no 639 0.194235572814729 217 2995857
SGTC_316 k060-0003 58.6 µM 0.862260822571859 0.183926411681904 no 640 0.194272003207334 225 6152314
SGTC_2120 5538279 151.968 µM 0.86205268797565 0.18398360392461 no 641 0.194329262462897 187 2058197
SGTC_1235 benzylparaben 21.5 µM 0.861883183050222 0.184030189497755 no 642 0.194375902022081 228 7180
SGTC_204 PMA1.184 62.41 µM 0.861311698991222 0.184187306376498 no 643 0.194533197014927 233 2252213 YGL008C PMA1
SGTC_2802 7925815 54.55 µM 0.859897196315525 0.184576551462166 no 644 0.194922857075658 208 1262923
SGTC_417 st075190 100 µM 0.859832478205705 0.184594372923591 no 645 0.194940696641031 232 222757
SGTC_226 1,3-diallylurea 8.28947 mM 0.859386611525935 0.184717180553702 no 646 0.195063626896135 217 74537 YKL182W FAS1
SGTC_483 fpl-64176 144 µM 0.858394246647474 0.184990695613623 no 647 0.19533740171297 206 3423
SGTC_2317 5986382 200 µM 0.85824725577378 0.185031230543474 no 648 0.195377973572518 238 877883
SGTC_1230 0170-0365 3.77 µM 0.857471996518826 0.185245111156954 no 649 0.19559204235718 220 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_995 3931-2021 34.6 µM 0.855629148426443 0.185754136958063 no 650 0.196101470861524 211 730143
SGTC_1552 6-methylflavone 10.6 µM 0.853375594880138 0.186377784537719 no 651 0.19672552545954 219 689013
SGTC_3057 9095946 49.47 µM 0.851586058185532 0.186873943099159 no 652 0.197221940169431 250 24540043
SGTC_2826 7992541 19.48 µM 0.851470364674492 0.186906047845022 no 653 0.197254059429986 275 2985066
SGTC_1833 st055984 71 µM 0.850193543556365 0.1872605901039 no 654 0.197608745364861 202 676288
SGTC_2635 hydroquinidine 100 µM 0.849338404387247 0.187498273866413 no 655 0.197846508412518 201 442912 An experimental heart treatment.
SGTC_611 3453-1652 23.7 µM 0.848706040223554 0.187674157737737 no 656 0.198022442167448 242 1560575
SGTC_2381 9035592 200 µM 0.846499788333492 0.188288595764687 no 657 0.198636995943407 214 4749657
SGTC_1991 st073000 8.92 µM 0.845228232788856 0.1886432852929 no 658 0.198991710980137 234 4301969 YIL048W NEO1
SGTC_1322 1348-1070 12 µM 0.844524120290368 0.188839868517066 no 659 0.199188295354736 225 6758089
SGTC_2379 9035213 200 µM 0.842599266699166 0.189377917933784 no 660 0.199726300672385 230 646551
SGTC_2287 7945887 168.79 µM 0.840084104043883 0.190082395322279 no 661 0.200430616045153 226 1245853
SGTC_2225 6654152 15.4 µM 0.838534042914709 0.190517356366092 no 662 0.200865418249098 230 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1641 st009299 47.1 µM 0.835940609272087 0.191246462307642 no 663 0.201594157669661 224 4046054
SGTC_2735 sertaconazole 140 nM 0.835215073495063 0.191450741873951 no 664 0.201798312092133 248 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2216 7189485 200 µM 0.831979725070372 0.19236330271689 no 665 0.202710194394666 221 731273
SGTC_2098 5376439 882.5 nM 0.829744398781003 0.192995348826402 no 666 0.203341656546672 226 2844116
SGTC_2964 9083345 53.42 µM 0.828687053474666 0.19329475810265 no 667 0.203640756769255 247 17741579
SGTC_1488 4013-0813 75.9 µM 0.826870953022731 0.193809685782342 no 668 0.204155104346375 219 2910057
SGTC_2153 5569715 200 µM 0.826796204247414 0.193830897562449 no 669 0.204176290914709 228 2054701
SGTC_3036 9090181 49.47 µM 0.826307141431629 0.193969715927132 no 670 0.204314941718397 241 25236586
SGTC_570 0987-0065 62.6 µM 0.824759857237997 0.194409304730788 no 671 0.204753970597943 220 3104428
SGTC_592 k241-0073 46.5 µM 0.824736432398745 0.194415964465761 no 672 0.204760621507903 229 4230158
SGTC_986 1493-0483 84 µM 0.824370536943144 0.194520007400606 no 673 0.204864525247802 225 40079
SGTC_1841 st054148 70 µM 0.823017515154781 0.19490503547871 no 674 0.20524901658159 230 675442
SGTC_1389 3405-0187 19 µM 0.822607333339759 0.195021851998099 no 675 0.205365663529598 234 799890
SGTC_1957 st077035 62.4 µM 0.821149256467757 0.195437445157053 no 676 0.205780628084908 234 705593
SGTC_665 3914-0008 307 µM 0.820987669411187 0.1954835351268 no 677 0.205826645909079 226 1069549
SGTC_2581 avocatin a 64 µM 0.820338985567288 0.195668627634657 no 678 0.206011443803827 223 6710728 A skin care supplement.
SGTC_1905 st060207 84.5 µM 0.820038441403614 0.195754419597939 no 679 0.206097096560809 225 1948547
SGTC_1302 1159-0335 255 µM 0.815637495394598 0.197013306922509 no 680 0.20735374882032 209 649284
SGTC_3079 9117512 49.47 µM 0.815298341983436 0.197110524443419 no 681 0.207450778804626 280 7185044
SGTC_766 1391-0721 126 µM 0.814833754119285 0.19724374456363 no 682 0.20758373847226 251 1020919 YIL115C NUP159
SGTC_2754 granisetron 64.02 µM 0.814131840327362 0.197445120947918 no 683 0.207784713556095 246 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2833 9001315 45.46 µM 0.812552479245755 0.197898687955655 no 684 0.208237343260973 221 2989378
SGTC_704 1310-0270 142 µM 0.812462534077553 0.197924537685086 no 685 0.208263138178694 238 5718033
SGTC_1689 st020265 53.493 µM 0.81184368883034 0.198102445571516 no 686 0.208440664761514 227 5758320 YPR016C TIF6
SGTC_3257 9139206 32.98 µM 0.807645708918502 0.199311843318322 no 687 0.209647282769524 237 4910041
SGTC_3085 9117376 49.47 µM 0.807332501964528 0.1994022531165 no 688 0.209737471664554 246 16480349
SGTC_3321 9137793 26.8275 µM 0.806567617856067 0.199623147040013 no 689 0.209957818226582 238 4904192
SGTC_438 sphingosine 6.67 µM 0.806149734494861 0.199743891412313 no 690 0.210078258823571 224 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2066 5222451 176 µM 0.805859575851071 0.199827756491157 no 691 0.210161911007451 236 2281147
SGTC_919 tnp00227 403.569 nM 0.804566982665986 0.200201614291943 no 692 0.210534800806219 239 1269246 A methoxyflavone. YNL221C POP1
SGTC_2925 9010536 32.5 µM 0.803479671148092 0.200516423583214 no 693 0.210848771021413 218 2994177
SGTC_3356 9151811 4.48 µM 0.802355342055923 0.200842263011498 no 694 0.211173718953685 265 1859254 YPR165W RHO1
SGTC_2352 9027995 87.8 µM 0.802247639746218 0.200873492657272 no 695 0.211204861927346 218 2997347
SGTC_508 roscovitine 141 µM 0.801760503659408 0.201014780312751 no 696 0.21134575478417 258 160355 A CDKinase inhibitor.
SGTC_1134 3477-0009 42.5 µM 0.801401852027749 0.20111884076996 no 697 0.211449521660006 233 3973534
SGTC_2013 4024628 200 µM 0.79865129801191 0.201917969697788 no 698 0.212246316893054 247 5230760
SGTC_827 3253-0474 693 µM 0.797277220807635 0.202317896556774 no 699 0.212645023417759 246 5402065
SGTC_1409 3909-8004 61.9 µM 0.797042190865194 0.202386349727089 no 700 0.212713264215158 222 2119279
SGTC_3345 9148410 3.559 µM 0.79646495094254 0.202554531343371 no 701 0.212880919723056 230 4903596
SGTC_1184 1269-1718 139 µM 0.795005396229501 0.202980152116767 no 702 0.21330518159119 234 5403821
SGTC_420 mitomycin C 81.9 mM 0.794527414985941 0.203119652246041 no 703 0.213444227775039 226 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_906 1165-0455 526 µM 0.792537288779194 0.203701090991035 no 704 0.214023729097661 241 3252859
SGTC_1555 citronellol 128 µM 0.791397290950611 0.204034601308233 no 705 0.214356095170046 245 8842 A terpine precursor.
SGTC_1495 4469-0029 237 µM 0.790878410347615 0.204186509296909 no 706 0.214507474032584 243 793680
SGTC_256 clotrimazole 625 nM 0.788549563976148 0.204869133745971 no 707 0.215187659560001 229 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2374 9071832 200 µM 0.786155382044373 0.205572321877317 no 708 0.215888230965596 232 17381698
SGTC_1529 apigenin 74 µM 0.784928002194279 0.205933366889655 no 709 0.216247891469148 243 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.783810196267204 0.206262506764396 no 710 0.216575745032047 252 616764
SGTC_3267 9137951 49.47 µM 0.782278839282414 0.206713923286585 no 711 0.217025360009137 266 16643986
SGTC_2850 9015429 58.44 µM 0.781578659875737 0.206920518322751 no 712 0.217231116167748 262 6457570
SGTC_363 0455-0021 3.06 µM 0.780977467861568 0.207098003592056 no 713 0.217407873560339 241 4597466
SGTC_657 3534-0529 86.7 µM 0.780164475856318 0.207338160123373 no 714 0.217647034619061 237 1049549
SGTC_2545 solidagenone 89.61 µM 0.779203110191948 0.207622358368526 no 715 0.217930039143171 202 6708572 An anti ulcer agent
SGTC_1676 st018489 23.4 µM 0.778904196718698 0.207710769847677 no 716 0.218018075802607 242 3696235
SGTC_2030 5175110 200 µM 0.778859214029031 0.207724076579892 no 717 0.218031325978841 256 2831986
SGTC_2224 6650123 117.647 µM 0.778281851111584 0.207894916182408 no 718 0.218201436179476 247 2908370
SGTC_2868 9035608 32.47 µM 0.778133156006492 0.207938927958629 no 719 0.218245259054507 247 6462614
SGTC_930 2810-3379 265 µM 0.775926796029071 0.2085926273868 no 720 0.218896104994037 252 1015764
SGTC_2428 5615643 7.78 µM 0.77587056512426 0.208609303272504 no 721 0.218912706918148 257 2253075
SGTC_1278 0874-0585 172 µM 0.77425782664691 0.209087912808728 no 722 0.219389168979405 251 766306
SGTC_2245 6637752 200 µM 0.771947365216539 0.209774709902148 no 723 0.220072801212675 234 681890
SGTC_2966 9084041 48.03 µM 0.769430972194119 0.210524228073264 no 724 0.220818753975161 231 17741380
SGTC_2386 9075165 157.42 µM 0.76643225321695 0.211419458292718 no 725 0.221709573898695 251 16452277
SGTC_1467 k284-1082 293 µM 0.766404091565188 0.211427876156672 no 726 0.221717949511495 259 3334705
SGTC_1819 st053448 58.6 µM 0.765911441537856 0.211575167055475 no 727 0.221864498774656 279 2857616
SGTC_422 cantharidin 155 µM 0.764794856706083 0.211909222230943 no 728 0.222196855468863 260 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2549 cedrol 20.94 µM 0.764794199206003 0.211909419029916 no 729 0.2221970512605 251 6708665 A sedative which affects the nervous system.
SGTC_2059 5238311 157 µM 0.763843696456236 0.212194029578528 no 730 0.222480196726306 262 703021
SGTC_2296 7971656 126.45 µM 0.762667171436698 0.212546627633624 no 731 0.222830956817188 242 666570
SGTC_319 1348-1596 45.5 µM 0.759056603531941 0.213630829231254 no 732 0.223909348670219 248 5380505
SGTC_709 3807-1509 243 µM 0.756975906764542 0.21425709322059 no 733 0.224532148501746 277 1886677 YPL242C IQG1
SGTC_1469 k284-2957 126 µM 0.756664282394563 0.214350980170678 no 734 0.224625509311126 233 23884841
SGTC_2521 angolensin 13.4 µM 0.75520040472492 0.214792340896287 no 735 0.225064372932151 260 821428 A flavenoid.
SGTC_180 1486-1293 102.781 µM 0.754697854613461 0.214943981965964 no 736 0.225215147037756 246 4140536
SGTC_507 nimesulide 162 µM 0.750948330121484 0.216077336314713 no 737 0.226341876256183 242 4495 A COX2 inhibitor.
SGTC_2145 5634607 200 µM 0.750418486589709 0.216237768732177 no 738 0.226501350178401 251 308662
SGTC_1077 5-fluorocytosine 377 nM 0.749537274474578 0.216504745448793 no 739 0.226766720530465 264 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_963 1269-2853 151 µM 0.748187372562355 0.216914088562972 no 740 0.227173573251362 232 3668223
SGTC_2490 carminic acid 95.39 µM 0.747292022125318 0.217185840466249 no 741 0.227443653549685 242 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2256 7954252 200 µM 0.746113341890373 0.217543886787746 no 742 0.227799475206063 255 2972920
SGTC_59 0330-0160 1.33 µM 0.742956685556718 0.218504456815235 no 743 0.228753952364557 261 4293482
SGTC_1393 3470-5649 58.2 µM 0.742390588841866 0.218676977864125 no 744 0.228925359962348 234 4108395
SGTC_1748 st037455 53.6035 µM 0.741310016464946 0.219006505737928 no 745 0.229252744903134 260 580690
SGTC_1080 nisoldipine 24.4 µM 0.740987411367832 0.219104941681902 no 746 0.229350536604707 256 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2218 6965428 192.983 µM 0.740807167101055 0.219159950383791 no 747 0.229405184463756 249 675684
SGTC_1133 3473-0247 50 µM 0.740305700191108 0.219313034709649 no 748 0.229557261493852 249 711311
SGTC_2872 9044037 25.97 µM 0.738464625135968 0.219875591973201 no 749 0.230116077987127 248 6465195
SGTC_1298 1079-1278 263 µM 0.738092487091511 0.219989402678999 no 750 0.230229124428926 256 2840950
SGTC_869 0564-0080 44.1 µM 0.737821421347968 0.220072323789415 no 751 0.230311487125244 234 6843321
SGTC_1312 1218-2183 165 µM 0.735729139100544 0.220712972148288 no 752 0.230947776346403 262 6744073
SGTC_3192 9110362 49.47 µM 0.73567042765315 0.220730964749915 no 753 0.230965645377429 272 16649480
SGTC_2091 4-phenylthiadiazole 200 µM 0.732487392894994 0.221707688266849 no 754 0.23193556741636 246 270010
SGTC_1311 1190-0148 100 µM 0.7320393736602 0.221845362248862 no 755 0.232072267970576 261 1961333
SGTC_3122 9126309 49.47 µM 0.731290890793861 0.222075476039739 no 756 0.232300746635543 290 17591206
SGTC_1681 tripelennamine 100 µM 0.730243783044909 0.22239762767823 no 757 0.232620592150291 238 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1181 1222-0449 220 µM 0.729768653958478 0.222543893069392 no 758 0.232765803962575 269 658318
SGTC_997 3996-0078 137 µM 0.729549344163954 0.222611424656725 no 759 0.232832847730283 250 735687
SGTC_1395 3486-0190 4.35 µM 0.72816897480647 0.223036746869892 no 760 0.233255077644075 263 6748079
SGTC_3040 9091894 49.47 µM 0.727764271524432 0.223161532541927 no 761 0.233378949538613 227 25236966
SGTC_1619 st003326 88.7 µM 0.726857720345883 0.223441201517337 no 762 0.233656559828197 228 2849032
SGTC_925 2064-1272 59.6 µM 0.725086715134526 0.223988127450642 no 763 0.234199416948388 255 6815817
SGTC_2800 7887935 81.82 µM 0.724428308522622 0.224191651890482 no 764 0.234401412853291 262 2961002
SGTC_2306 7482397 179.52 µM 0.724074939806233 0.224300927332389 no 765 0.23450986437742 277 891448
SGTC_419 nsc-638432 893 µM 0.722459578744713 0.224800845095873 no 766 0.235005984176989 250 368090
SGTC_1797 st048695 56.8 µM 0.722073392020307 0.224920454669402 no 767 0.235124678090059 286 592262 YIL048W NEO1
SGTC_2409 alverine citrate 63.97 µM 0.721810720977864 0.225001829631323 no 768 0.235205428558164 233 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2267 7931562 200 µM 0.721197462110677 0.225191880933865 no 769 0.235394016517267 251 934880
SGTC_1063 disulfiram 1.84 µM 0.720815800671016 0.225310205186373 no 770 0.235511426286204 285 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_784 4579-0127 173 µM 0.717747113597607 0.226262850794016 no 771 0.236456613914133 258 1948547
SGTC_1021 4476-0760 85.3 µM 0.716277575634635 0.22671985986756 no 772 0.236909985193648 246 746768
SGTC_339 3091-4833 71.4 µM 0.716219278249778 0.226738000406052 no 773 0.236927980532971 263 3240077
SGTC_594 1487-1584 10.8 µM 0.715322320958041 0.227017212001999 no 774 0.237204949586617 279 5013332
SGTC_515 4092-1064 102 µM 0.715160676628886 0.227067550471639 no 775 0.237254882216175 294 717353
SGTC_1453 4237-0541 195 µM 0.715079327539422 0.227092886179076 no 776 0.237280013483945 251 739892
SGTC_2143 5623677 140.463 µM 0.713595712000242 0.22755522921643 no 777 0.23773860491963 250 5375313
SGTC_1142 3253-1408 9.78 µM 0.713286006502348 0.227651810390918 no 778 0.237834397417746 267 256655
SGTC_3201 9113999 49.47 µM 0.713241381517862 0.227665728524359 no 779 0.237848201754642 259 16649224
SGTC_1508 1080-0625 72.9 µM 0.713186402929696 0.227682876512787 no 780 0.237865209489667 264 767111
SGTC_1746 st038117 42 µM 0.713023489174161 0.227733694076526 no 781 0.237915611098096 260 2898218
SGTC_1874 staurosporine 7.6 µM 0.711049810625068 0.228349849054326 no 782 0.238526684848129 271 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_265 mycophenolic acid 32.932 µM 0.709419094996528 0.228859641812758 no 783 0.239032220799461 269 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1726 st035556 14.5795 µM 0.708651484914362 0.229099832279358 no 784 0.239270389162689 245 5919439
SGTC_708 3448-5400 146 µM 0.708124074086576 0.229264944668158 no 785 0.239434105395622 279 3462195
SGTC_476 mead acid 10 µM 0.7076778020605 0.229404707663355 no 786 0.239572682694367 271 5312531 An omega 9 fatty acid.
SGTC_3215 9129942 49.47 µM 0.701430711711342 0.231366170365196 no 787 0.241517130648662 279 17682944
SGTC_2440 5628896 157.78 µM 0.699939583681403 0.231835733956879 no 788 0.241982517855107 285 5522048
SGTC_247 mechlorethamine 29.705 µM 0.699681229453636 0.231917144901875 no 789 0.242063200684509 249 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1973 st070275 50.2 µM 0.699335216448068 0.232026203260762 no 790 0.242171281793016 248 17118334
SGTC_2945 9067681 61.76 µM 0.69874028315264 0.23221378447582 no 791 0.242357177139522 301 16456930
SGTC_1813 st051246 8.6015 µM 0.698279768560268 0.232359041682095 no 792 0.24250112452835 254 5291959
SGTC_2495 cafestol 54.53 µM 0.697013234443505 0.232758797078905 no 793 0.242897255747901 281 16667697 An anti-infammatory.
SGTC_1729 st035615 45.989 µM 0.69669389078657 0.232859651621526 no 794 0.242997191433806 277 17385451
SGTC_2684 capsaicin 100 µM 0.69635630875463 0.232966292567729 no 795 0.243102858830654 286 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1888 azatryptophan 97.5 µM 0.695837405406935 0.23313026514217 no 796 0.243265330506106 248 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_365 0121-0052 13.6 µM 0.69475640423972 0.233472065357915 no 797 0.243603986710383 240 3101739
SGTC_2101 5377231 179.231 µM 0.694356618927061 0.233598543279367 no 798 0.243729295971927 283 2844213
SGTC_380 3970-0968 6 µM 0.694261244599082 0.233628721952719 no 799 0.243759195373435 261 2891601
SGTC_2111 5486399 200 µM 0.693500785241314 0.233869426440743 no 800 0.243997666607621 255 689674
SGTC_2714 st079313 56.9 µM 0.693401765913854 0.233900778653455 no 801 0.24402872717823 273 2939799
SGTC_25 0118-0223 35.662 µM 0.692930536863122 0.234050014497399 no 802 0.244176572423756 276 5333628
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.692153044640803 0.234296357576756 no 803 0.244420611418799 281 23847180
SGTC_1150 3909-7983 10.9 µM 0.691814713059342 0.234403600415406 no 804 0.244526847844854 276 23965914
SGTC_1388 3346-4487 254 µM 0.691574972373974 0.234479608790683 no 805 0.244602141694194 284 3345614
SGTC_2421 5690543 90.72 µM 0.688976211808551 0.235304404975891 no 806 0.245419118763648 284 3397993
SGTC_2551 apiole 73.87 µM 0.68881045926886 0.235357065897206 no 807 0.245471276389695 259 10659 A possible DNA adduct former.
SGTC_1906 st060206 94.7 µM 0.687168279762436 0.235879150941936 no 808 0.245988345389334 293 5133468
SGTC_2069 5228469 200 µM 0.685291961239985 0.236476454534528 no 809 0.246579851730167 287 2835210
SGTC_839 0122-0028 230 µM 0.68371191476336 0.236980088429019 no 810 0.247078549131234 290 759448
SGTC_1139 k015-0024 46.9 µM 0.683111671671196 0.237171568077388 no 811 0.24726814036361 275 2766652
SGTC_33 0986-0033 35.816 µM 0.682229416164084 0.237453164884769 no 812 0.247546948432055 243 2848082
SGTC_2343 7990716 14.84 µM 0.681863329228075 0.237570065747059 no 813 0.24766268754962 288 6456862
SGTC_2162 5663267 200 µM 0.681410537923157 0.237714697197656 no 814 0.247805878396121 284 6456493
SGTC_1367 1812-0510 76.9 µM 0.681369281312231 0.237727877862647 no 815 0.247818927594788 260 1142582 YDR527W RBA50
SGTC_495 decylubiquinone 155 µM 0.681254343091917 0.237764600447632 no 816 0.247855283743516 290 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1976 st070609 63.5 µM 0.68116749482336 0.237792350399816 no 817 0.247882756638044 268 682556
SGTC_467 ro 31-8220 72.8 µM 0.679533252382539 0.238314858253136 no 818 0.248400022886143 278 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1090 efavirenz 20.7 µM 0.679339226030789 0.238376935026603 no 819 0.248461473796346 270 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_504 lovastatin 124 µM 0.679219484742033 0.238415249461977 no 820 0.2484994016108 290 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1516 st013856 110 µM 0.677561902510907 0.23894598361986 no 821 0.249024754270987 267 5281404 A mutagen and neurotoxin.
SGTC_1281 0884-0031 11.8 µM 0.676742428763925 0.239208605858586 no 822 0.249284695687934 286 1548255
SGTC_383 2324-0395 7.37 µM 0.675279009671725 0.239677989644641 no 823 0.249749258601598 258 3146421
SGTC_1392 3455-1037 33.9 µM 0.675175004995484 0.239711367704427 no 824 0.249782292411281 259 981132
SGTC_1926 methyl fluorone black 53.6 µM 0.674933611359024 0.239788847565534 no 825 0.249858972436979 247 72721 Reacts with homocysteine.
SGTC_1677 st019204 53.9 µM 0.674422380898216 0.239952981767364 no 826 0.250021408870969 267 3945625
SGTC_2430 5571206 200 µM 0.674412141450803 0.239956269841062 no 827 0.25002466288656 288 1731771
SGTC_1256 0570-0116 285 µM 0.673286951440478 0.240317738577945 no 828 0.250382376259264 282 410638
SGTC_3016 9080866 49.47 µM 0.673252026000348 0.240328963165522 no 829 0.250393483876071 276 17066299
SGTC_1642 st009582 77.7 µM 0.672663935757257 0.240518010701025 no 830 0.250580558135573 293 6739311
SGTC_2276 7947513 42.08 µM 0.672265467676614 0.240646148287816 no 831 0.250707354766529 279 2105100
SGTC_3032 9089427 49.47 µM 0.671417114851827 0.240919081535865 no 832 0.250977422476774 263 17173707
SGTC_1244 0416-0015 52.5 µM 0.671363297945391 0.240936401263401 no 833 0.250994559937033 272 96201
SGTC_2395 5646831 180.19 µM 0.670954537306936 0.241067973532169 no 834 0.251124745919872 296 6808628
SGTC_2653 dihydrofissinolide 100 µM 0.670289927658064 0.241281982099409 no 835 0.251336493359388 283 6857746
SGTC_1114 scopoletin 1.73284 µM 0.670243318853006 0.241296994306477 no 836 0.251351346662416 277 5280460 A coumarin with genotoxic properties.
SGTC_702 1488-0190 94 µM 0.669435917363265 0.241557130387421 no 837 0.251608723150822 263 949357
SGTC_3310 9130229 44.1445 µM 0.669008206224027 0.241694995997993 no 838 0.251745121608499 283 7761258
SGTC_2764 methyldopa 94.69 µM 0.667940473764306 0.242039348215879 no 839 0.252085795248367 294 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_249 wiskostatin 11.211 µM 0.66792770597882 0.242043467537526 no 840 0.252089870443912 265 2775510 A n-wasp and actin depolymerizer.
SGTC_413 propylparaben 100 µM 0.667371359943309 0.242223000599516 no 841 0.252267477574047 275 7175 A pharmaceutical preservative.
SGTC_2522 biochanin a 4.94 µM 0.666620699124881 0.24246535346842 no 842 0.252507222011462 266 5280373 A possible chelator.
SGTC_1715 st032160 10.2275 µM 0.665539677019646 0.24281459502697 no 843 0.252852687343773 264 5289825
SGTC_245 methotrexate 289.6 µM 0.664860023181348 0.243034307425935 no 844 0.253070013585581 254 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_304 1310-0298 97 µM 0.664734255013443 0.24307497641832 no 845 0.253110240010794 305 1550234
SGTC_2643 anethole 100 µM 0.662130926760976 0.243917626991332 no 846 0.253943658504871 307 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_326 k292-0812 17.5 µM 0.66165744933138 0.244071052351742 no 847 0.254095390192459 280 3579357
SGTC_459 nigericin 15.3 µM 0.661088994689072 0.244255322812215 no 848 0.254277621302147 300 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_966 1300-0360 30.2 µM 0.659392059165363 0.244805847858415 no 849 0.254822020007496 291 70588
SGTC_1883 5-benzylidenerhodanine 20 µM 0.657777440838733 0.245330286767347 no 850 0.255340576173739 265 1273210
SGTC_357 1325-0123 420 µM 0.657311589061648 0.245481710736939 no 851 0.255490293133355 297 1098503
SGTC_3222 9128301 49.47 µM 0.657238120611732 0.245505596058521 no 852 0.255513908849069 266 4911358
SGTC_2283 7944793 200 µM 0.656852419812212 0.245631011694324 no 853 0.255637907310516 277 2970533
SGTC_356 1634-0012 32.5 µM 0.654854948477826 0.246281065659626 no 854 0.256280574288777 296 735457
SGTC_3082 9117008 49.47 µM 0.654843218263534 0.246284885844444 no 855 0.256284350857065 294 41448529
SGTC_1857 st056007 79.3 µM 0.654627500371326 0.246355144462997 no 856 0.256353806878681 278 619834
SGTC_675 1309-0189 238 µM 0.65391567605727 0.246587059529474 no 857 0.256583066924419 265 4246530
SGTC_2234 tolnaftate 200 µM 0.653055733496892 0.246867387989757 no 858 0.256860174353807 291 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2113 5491891 107.031 µM 0.652963154584799 0.246897577502708 no 859 0.256890016216144 283 789979
SGTC_905 2-aminofluorene 215 µM 0.652634760928085 0.247004680939552 no 860 0.256995885089682 284 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2705 st078069 42.8 µM 0.65035032829088 0.247750421103219 no 861 0.257732977334907 278 1530061
SGTC_2058 5236698 133 µM 0.649831941807944 0.247919812648162 no 862 0.25790039192118 274 766665
SGTC_2636 apigenin dimethyl ether 100 µM 0.649697658606802 0.24796370203127 no 863 0.257943768313169 301 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1354 1498-1681 81 µM 0.648338378548488 0.248408205084215 no 864 0.258383058273836 278 5754243
SGTC_3054 9094397 49.47 µM 0.646585609170266 0.248982010801085 no 865 0.258950087129142 299 2598354
SGTC_2491 paeonol 100 µM 0.646527893004664 0.24900091738271 no 866 0.258968769511338 289 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1170 0310-0127 64.8 µM 0.643738209696155 0.249915668089851 no 867 0.25987260404838 312 774975
SGTC_1125 tnp00248 1.32998 µM 0.643614450031881 0.249956290763034 no 868 0.259912738830832 304 24207736
SGTC_1896 st058441 89 µM 0.64317505876703 0.250100544146537 no 869 0.260055257547642 283 688759
SGTC_687 k029-0044 34.9 µM 0.642680249473266 0.250263044278536 no 870 0.260215799597285 277 5829338
SGTC_2597 laccaic acid a 100 µM 0.641508189704263 0.25064818323513 no 871 0.260596280850025 293 5491415 A textile dye.
SGTC_2260 7964312 200 µM 0.637925058477392 0.251827544698721 no 872 0.261761232441425 291 231951
SGTC_266 formosanin C 406 nM 0.636119063648335 0.2524230832031 no 873 0.262349410488772 278 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1144 3486-0183 12.5 µM 0.635293743602306 0.252695484743155 no 874 0.2626184266293 323 6744069
SGTC_1929 genistein trimethyl ether 50.5 µM 0.632116357080501 0.253745642647538 no 875 0.263655423778389 282 136420
SGTC_2621 lithochol-11-enic acid 100 µM 0.631915408827368 0.253812135007532 no 876 0.26372107701204 314 6708711
SGTC_1526 st051518 75 µM 0.630245696850588 0.254364984498262 no 877 0.264266922794614 295 673993
SGTC_2419 paclitaxel 166.5 µM 0.62840771195299 0.254974278953461 no 878 0.264868443175017 306 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2602 kawain 100 µM 0.62825399924038 0.255025269504286 no 879 0.264918780507174 287 5369129
SGTC_1755 st041960 45.185 µM 0.627991647547089 0.255112310784493 no 880 0.265004705803282 307 2257073
SGTC_636 0kpi-0074 126 µM 0.627498911159146 0.255275829535367 no 881 0.265166124842816 300 616434
SGTC_854 0422-0053 192 µM 0.626852772833233 0.255490339028083 no 882 0.265377873564269 308 3596728
SGTC_752 1896-0090 130 µM 0.623595975175234 0.256572985302561 no 883 0.266446477258678 300 772567
SGTC_499 genistein 192 µM 0.620477629570665 0.25761184125825 no 884 0.267471688758798 315 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2734 clemastine 41.6 µM 0.620068591631567 0.257748271374465 no 885 0.267606314684151 326 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2869 9037858 32.47 µM 0.619467498669348 0.257948827368089 no 886 0.267804213297238 290 27187042
SGTC_244 nsc-207895 1.295 µM 0.618228631691584 0.258362433297013 no 887 0.268212319514412 270 42640
SGTC_1588 farnesol 29.9 µM 0.617631883805293 0.25856178504445 no 888 0.2684090111654 303 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3277 9138724 49.47 µM 0.617032778891106 0.258762004287548 no 889 0.268606552644993 282 15943418
SGTC_1252 0493-0875 34.8 µM 0.616530497162855 0.25892992729987 no 890 0.268772225127039 285 3960963
SGTC_890 0929-0006 47.2 µM 0.615476653517244 0.259282431820032 no 891 0.269119991394864 294 1378169
SGTC_2051 5263410 176 µM 0.614634822088707 0.259564197566994 no 892 0.269397956187005 297 227584
SGTC_406 estrone 100 µM 0.612346612395652 0.260330872455056 no 893 0.270154228034392 308 5870 A steroid.
SGTC_685 1278-0033 54.9 µM 0.610936021626467 0.260804077801355 no 894 0.270620968215478 307 3590572
SGTC_1148 3909-7663 27.7 µM 0.609819397699294 0.261178980795122 no 895 0.270990725211076 321 4084526
SGTC_933 2914-0560 114 µM 0.607197921722031 0.262060220197017 no 896 0.271859785656455 275 463887
SGTC_1690 st023502 41.2 µM 0.606895568775299 0.262161957567566 no 897 0.271960109523345 307 24207482
SGTC_314 1671-0008 2.74 µM 0.605638597623588 0.262585126937451 no 898 0.272377382987119 311 3913060
SGTC_1450 4112-4260 37.6 µM 0.605009036395698 0.262797205059682 no 899 0.272586496265653 313 1633175
SGTC_819 1013-0258 27.7 µM 0.604843094780253 0.262853119825053 no 900 0.272641628232361 310 5753198
SGTC_2912 7964298 10.93 µM 0.603050809357324 0.263457425818775 no 901 0.273237444461026 302 2975850
SGTC_887 0885-0007 9.62 µM 0.601019460627372 0.264143193265978 no 902 0.273913512321086 307 5719458
SGTC_213 1246-0773 967 nM 0.600840230369258 0.264203743623942 no 903 0.273973202915692 310 6251622
SGTC_2516 gossypol 71.55 µM 0.60045401083986 0.264334246347452 no 904 0.274101850777439 312 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_633 0437-0093 97.7 µM 0.598525241252605 0.264986464127912 no 905 0.274744760954318 309 2831118
SGTC_1647 st011722 22.4 µM 0.597961361197716 0.265177295792516 no 906 0.274932857523122 303 2854783
SGTC_830 4076-0286 57.8 µM 0.597797861924822 0.265232641244049 no 907 0.274987408738621 300 6866659
SGTC_1028 k015-0029 4.8 µM 0.597210465317849 0.265431526773667 no 908 0.275183436460459 305 4588309
SGTC_2673 kobusone 100 µM 0.597061164251264 0.265482090404583 no 909 0.275233272615426 326 6710676 An epoxy ketone and protein crosslinker.
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.597018629843889 0.265496496380757 no 910 0.275247471259625 279 6708630 An antioxidant.
SGTC_917 harmaline 728.087 nM 0.596822335670122 0.265562984382001 no 911 0.275313001967479 291 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1054 3429-0080 167 µM 0.59568638196378 0.265947916000083 no 912 0.275692378669783 311 1162877
SGTC_732 3970-1727 52.7 µM 0.594333347539944 0.266406776623881 no 913 0.276144589323084 313 1275699
SGTC_1790 st045711 43.5 µM 0.593955785307673 0.266534892439759 no 914 0.276270842974374 269 585119
SGTC_531 3788-1495 174 µM 0.593558736562223 0.266669654096508 no 915 0.2764036432985 311 2896655
SGTC_2399 5884133 200 µM 0.593071261041657 0.266835154447868 no 916 0.27656673134074 303 722445
SGTC_1572 epiandrosterone 68.9 µM 0.59182469837515 0.267258604553544 no 917 0.276983991243692 303 441302 A steroid.
SGTC_1352 1496-0991 99 µM 0.59112168072683 0.267497565030106 no 918 0.277219447037135 323 3000039
SGTC_1717 st033143 58.0435 µM 0.59063878774141 0.267661766034304 no 919 0.277381235031547 327 674616
SGTC_2756 carbadox 75.1 µM 0.590087308597109 0.2678493509187 no 920 0.277566058513111 306 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2976 9009005 19.48 µM 0.587703013602264 0.268661126964707 no 921 0.278365826218043 282 2993148
SGTC_1499 4480-0877 67.3 µM 0.587644221935925 0.268681159249471 no 922 0.278385560975955 301 2861909
SGTC_1995 st072814 61.1 µM 0.587597413594323 0.268697108951782 no 923 0.278401273746314 303 5769371
SGTC_275 trichlorophene 5.69 µM 0.58616449053409 0.269185600196576 no 924 0.278882490846375 295 62616
SGTC_312 4092-0653 6.84 µM 0.58198081369938 0.270614382894896 no 925 0.2802898021966 307 1148278
SGTC_162 k030-0015 37.8 µM 0.580943693864434 0.27096915843631 no 926 0.280639201366409 338 1809920 YMR134W ERG29
SGTC_3202 9113761 49.47 µM 0.576316699110343 0.272554771586409 no 927 0.282200568800215 311 4798415
SGTC_2141 5621638 7.665 µM 0.576007696549099 0.272660826751185 no 928 0.282304989673455 304 2856238
SGTC_305 1682-2595 20.8 µM 0.575319487683174 0.272897105831422 no 929 0.282537622077805 319 226033
SGTC_2794 7785382 27.27 µM 0.575261594536366 0.272916986606054 no 930 0.282557195661341 320 2205081
SGTC_1590 st077108 57.8 µM 0.574926383611449 0.273032113706464 no 931 0.282670542770827 284 5489485
SGTC_2105 5350118 200 µM 0.574140851365734 0.27330199647334 no 932 0.282936245604809 315 2133313
SGTC_1211 1056-0033 32.3 µM 0.573008690502758 0.273691201616463 no 933 0.283319404884196 290 6741922
SGTC_2834 9001755 58.44 µM 0.568528650333555 0.275233997684326 no 934 0.284838028605398 334 2989575
SGTC_1267 0828-0272 9.49 µM 0.568320724131769 0.275305705275259 no 935 0.284908604692018 311 745334
SGTC_1484 3473-2379 286 µM 0.567488213543766 0.275592905604838 no 936 0.285191266072115 315 671917
SGTC_1342 1486-1464 234 µM 0.565928940579718 0.276131221203543 no 937 0.285721043534082 312 3253938
SGTC_3158 9100007 49.47 µM 0.5653298773829 0.276338175944818 no 938 0.285924705224905 311 19297233
SGTC_1 0258-0098 57.368 µM 0.565119873430616 0.276410742748575 no 939 0.285996115961934 283 6790032 YDR047W HEM12
SGTC_2073 5212005 126 µM 0.564173538404098 0.276737864440355 no 940 0.286318017316759 341 691789
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.563465079501681 0.276982883057921 no 941 0.286559116258754 318 1377
SGTC_538 2922-0838 53.3 µM 0.562509602075306 0.277313500479163 no 942 0.286884431669509 298 777039
SGTC_1591 genipin 88.4 µM 0.560958370333378 0.277850673414443 no 943 0.287412958424849 324 442424 A DNA cross-linking agent.
SGTC_1018 4259-0013 28.1 µM 0.56074881159835 0.27792328001771 no 944 0.287484393367928 315 6801262
SGTC_1180 1193-0155 285 µM 0.560474033492045 0.278018497451478 no 945 0.287578073185027 329 2921347
SGTC_1353 1498-1206 8.11 µM 0.559960284754028 0.278196566829421 no 946 0.287753263717029 294 6756808
SGTC_678 1218-2179 85.9 µM 0.559550763120091 0.278338550093378 no 947 0.287892948463246 326 6820081 YOR116C RPO31
SGTC_3208 9114115 49.47 µM 0.55902591900958 0.278520567879737 no 948 0.288072015639329 330 650895
SGTC_2281 7943571 200 µM 0.55875291858486 0.278615268307409 no 949 0.288165179149604 320 1244024
SGTC_112 phenothiazine 287.218 µM 0.556796355988563 0.279294433887166 no 950 0.288833286937117 336 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_935 2996-0153 430 µM 0.556193415635387 0.279503889676001 no 951 0.28903931995819 326 23738523
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.555640643146501 0.279695984617781 no 952 0.289228270649897 334 61125 An anti-inflammatory.
SGTC_1747 st037496 66.6 µM 0.555049372166066 0.279901529128062 no 953 0.289430445282551 319 723305
SGTC_2170 morpholine 200 µM 0.554585047821793 0.280062994302577 no 954 0.289589259284464 319 121171 Reacts with secondary amines.
SGTC_2575 plumbagin 510 nM 0.550595661037311 0.281452129668641 no 955 0.29095544196652 314 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_851 0394-0702 453 µM 0.549788586901459 0.281733562927435 no 956 0.291232193826198 330 762646
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.548494557521629 0.282185084331992 no 957 0.291676182638395 318 1241132 A phosphatase inhibitor.
SGTC_3333 9141820 12.094 µM 0.548382395310791 0.282224237120324 no 958 0.291714680982103 329 1939433
SGTC_399 oxolinic acid 75 µM 0.54649478639915 0.282883542179347 no 959 0.292362935269655 319 4628 A DNA gyrase inhibitor.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.545329538692812 0.283290909420416 no 960 0.292763445916219 346 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2223 6903751 107.57 µM 0.544706893265873 0.283508699737923 no 961 0.292977561556923 322 5598863
SGTC_2733 amorolfine 100 µM 0.544480867048084 0.283587779542928 no 962 0.293055305544557 354 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2456 5770359 74.46 µM 0.542248557027615 0.284369365037884 no 963 0.293823644456375 348 3118787
SGTC_147 4466-0538 29.23 µM 0.541449404341814 0.284649417641219 no 964 0.294098931214914 313 6742687 YHR072W ERG7
SGTC_1237 0330-0133 46.1 µM 0.541203626406976 0.284735573770494 no 965 0.294183619111265 345 X1237 YHR072W ERG7
SGTC_1997 st073024 93.8 µM 0.539975569581438 0.285166248823605 no 966 0.294606940319367 317 686268
SGTC_1839 st053978 48 µM 0.539759558128654 0.285242035348235 no 967 0.294681430283046 334 3788398
SGTC_2514 salinomycin 42.74 µM 0.539425438966754 0.285359278263194 no 968 0.294796665929654 340 23682228 A polyether potassium ionophore.
SGTC_2275 7947463 200 µM 0.539178211656276 0.285446045469529 no 969 0.294881946481754 324 1225414
SGTC_104 0074-0074 590.992 µM 0.537555781577825 0.28601576705555 no 970 0.295441882335388 321 3943124
SGTC_496 calpeptin 138 µM 0.536317254903355 0.286451043112258 no 971 0.295869653673222 313 73364 A calpain inhibitor.
SGTC_586 0957-0265 8.15 µM 0.536091744723211 0.286530331726976 no 972 0.295947572619426 331 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_135 0933-0004 26.348 µM 0.535385179382058 0.286778825098749 no 973 0.296191768156463 318 21230617 YGL099W LSG1
SGTC_2485 5633444 17.78 µM 0.535016412631553 0.286908557969228 no 974 0.296319254066433 308 5724239
SGTC_813 k007-0158 173 µM 0.534922795708751 0.286941497012499 no 975 0.296351622264322 327 6523916
SGTC_1052 3253-3998 198 µM 0.533620051945606 0.287400052241406 no 976 0.296802216099 306 5450317
SGTC_5 0352-0601 109.883 µM 0.532432239482267 0.287818454454616 no 977 0.297213330538367 317 762456
SGTC_3304 9125678 46.087 µM 0.532026470046298 0.287961451025535 no 978 0.29735383124602 322 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_513 4245-1575 41.7 µM 0.531424967059405 0.288173487441949 no 979 0.297562161970238 317 719745
SGTC_3209 9113616 49.47 µM 0.530983516096164 0.288329150611648 no 980 0.297715101013686 346 16649353
SGTC_2894 9048625 32.47 µM 0.530967666822328 0.288334740074238 no 981 0.297720592602483 356 4092861
SGTC_889 0919-1524 82.7 µM 0.530959609450973 0.288337581635731 no 982 0.297723384405537 323 3905452
SGTC_462 ag-879 158 µM 0.530430126885881 0.288524341108365 no 983 0.297906871286993 345 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1037 k284-1091 78.7 µM 0.529830703487259 0.288735838928267 no 984 0.298114657664004 309 3334711
SGTC_73 0327-0325 16.231 µM 0.528532223635023 0.289194238815096 no 985 0.298564993866435 296 53298
SGTC_1700 st030840 7.9285 µM 0.527043813781994 0.289720109811981 no 986 0.299081581488602 346 5499307
SGTC_1319 1306-0155 43.7 µM 0.526609966714653 0.289873477006384 no 987 0.299232234652588 336 3122360
SGTC_942 3253-1115 227 µM 0.526545405541315 0.289896302971427 no 988 0.299254656428714 364 46497897
SGTC_2969 9091408 28.7 µM 0.526129982210188 0.290043198380301 no 989 0.299398949125461 328 4286311
SGTC_132 0417-1715 25.805 µM 0.525877710055562 0.290132419882461 no 990 0.299486588460321 349 6769098
SGTC_1546 5-methoxyflavanone 78.7 µM 0.525653301104507 0.290211797767706 no 991 0.299564557891626 310 147795
SGTC_2309 7664088 163.95 µM 0.524774244350479 0.290522835475086 no 992 0.299870069003939 345 704922
SGTC_1271 0832-2808 169 µM 0.521533516682119 0.291670851588918 no 993 0.300997581698317 340 3663794
SGTC_282 k297-0036 65.7 µM 0.520909949219643 0.291891990465338 no 994 0.301214752112999 330 5061378
SGTC_2928 9011484 9.79 µM 0.520782174586997 0.29193731346663 no 995 0.301259261013741 339 2994751
SGTC_1972 st070201 17.4 µM 0.519512231357623 0.29238795368892 no 996 0.301701792819184 330 2829099
SGTC_2585 alliin 100 µM 0.519487219186365 0.29239683252189 no 997 0.301710511640348 352 87310 A garlic compound which reacts with lipids.
SGTC_2480 5767542 37.17 µM 0.518508827522328 0.292744240794871 no 998 0.302051651325701 339 2867358
SGTC_257 daunorubicin 18.5 µM 0.518351405938335 0.292800156102369 no 999 0.302106556304228 340 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_576 1073-0113 22.7 µM 0.518141153512616 0.292874844376269 no 1000 0.302179894436698 351 5439563
SGTC_2553 4-methylesculetin 85.09 µM 0.51719238970046 0.293211985056203 no 1001 0.302510932009852 329 5319502
SGTC_2107 5363541 170.161 µM 0.516964363258471 0.293293040452435 no 1002 0.302590517997069 326 244052
SGTC_129 0088-0017 176.636 µM 0.516938364060561 0.293302282914223 no 1003 0.302599592855667 333 182446
SGTC_1548 st061468 90.8 µM 0.515837237323256 0.293693846613337 no 1004 0.302984046219273 342 390799
SGTC_892 0929-0076 29 µM 0.51567334209572 0.293752148887055 no 1005 0.30304128817228 325 5751038
SGTC_331 k048-0133 24.5 µM 0.515510184010865 0.293810194256768 no 1006 0.303098277476757 322 6813582
SGTC_1988 st071872 53.4 µM 0.514646210232241 0.294117651297898 no 1007 0.303400133780554 317 16414116
SGTC_3148 9097893 49.47 µM 0.514029488981 0.294337211009074 no 1008 0.303615686794652 284 17174100
SGTC_551 k048-0028 34.9 µM 0.511954957425109 0.295076322522572 no 1009 0.304341266896297 340 6836383
SGTC_3066 9117245 49.47 µM 0.511024891078675 0.295407962694129 no 1010 0.304666813749236 314 17176980
SGTC_3242 9133940 49.47 µM 0.508669541077968 0.296248592087345 no 1011 0.305491937865951 337 17248444
SGTC_1483 3453-0561 55.9 µM 0.507563423404154 0.296643746066833 no 1012 0.305879773575709 337 4546991
SGTC_808 0711-0032 135 µM 0.505842894235971 0.29725887421119 no 1013 0.306483471838354 352 4252555
SGTC_133 0724-0033 378.92 µM 0.505747721428768 0.297292917653008 no 1014 0.306516881371479 336 280309
SGTC_228 caffeine 993.056 µM 0.50494873877985 0.297578785055381 no 1015 0.306797420233161 318 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2519 cryptotanshinone 88.04 µM 0.504739155395713 0.297653792505463 no 1016 0.306871027918093 319 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2149 5554786 194.827 µM 0.503794787649845 0.297991877686416 no 1017 0.307202795444304 332 745063 YPR165W RHO1
SGTC_441 propafenone 146 µM 0.502656523602995 0.298399610510988 no 1018 0.307602890841283 346 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_302 1094-0063 18.9 µM 0.502425389653185 0.298482435043841 no 1019 0.30768416150978 340 5440289
SGTC_2259 7964009 200 µM 0.50180174723543 0.298705963216498 no 1020 0.3079034919808 308 313134
SGTC_1263 0774-1208 64.8 µM 0.501621021822777 0.298770753692034 no 1021 0.307967064617125 365 906585
SGTC_2772 vinpocetine 57.06 µM 0.501305759159435 0.298883791367527 no 1022 0.308077976367223 385 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1055 3448-0672 86 µM 0.501236221336783 0.298908726823657 no 1023 0.308102442650554 320 748378
SGTC_1925 st057770 10.1 µM 0.497434768005713 0.300273319237866 no 1024 0.309441246406544 319 5989122
SGTC_2975 9084847 53.72 µM 0.49676744040343 0.300513157402183 no 1025 0.309676529109423 313 27211724
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.495403359305902 0.301003678383316 no 1026 0.310157711957149 356 1273210
SGTC_3000 9075062 71.4286 µM 0.494047518477082 0.301491593541081 no 1027 0.310636310369283 324 17057871
SGTC_727 3032-0951 202 µM 0.494007774079274 0.301505901394649 no 1028 0.31065034459029 352 3652836
SGTC_2190 6049624 200 µM 0.493443902646368 0.301708926178765 no 1029 0.310849483998796 345 2265554
SGTC_2761 levamisole 97.89 µM 0.493135523337977 0.301819985715934 no 1030 0.310958416086487 354 26879 An alkaline phosphatase inhibitor.
SGTC_2830 7992007 71.43 µM 0.491568654721072 0.302384560452755 no 1031 0.311512153446336 323 1952075
SGTC_939 1165-0479 45.3 µM 0.491521258473133 0.302401645666495 no 1032 0.311528910115075 363 1377347
SGTC_330 1488-0319 80.1 µM 0.4902607910173 0.302856172792183 no 1033 0.3119746842257 343 6846614
SGTC_1258 0671-0043 57.1 µM 0.488875523750011 0.303356055471843 no 1034 0.312464912568571 356 4298767
SGTC_108 0509-0257 621.132 µM 0.486779935108636 0.304112962143952 no 1035 0.31320714552241 340 536624
SGTC_193 1273-0060 1.558 µM 0.485595186839616 0.304541253990769 no 1036 0.313627104842521 339 2847393 YHR072W ERG7
SGTC_1228 0124-0032 52.5 µM 0.485053811291063 0.30473705298508 no 1037 0.313819087441107 352 X1228
SGTC_2050 5263056 171 µM 0.48451028800929 0.304933685028194 no 1038 0.314011882389768 339 763468 YGL055W OLE1
SGTC_3105 9121040 49.47 µM 0.484470125935182 0.304948216817961 no 1039 0.314026130427676 313 41448907
SGTC_1364 1653-0028 37.6 µM 0.483772602705667 0.305200649770029 no 1040 0.314273630412498 327 5718652
SGTC_1425 4048-4433 7.33 µM 0.483684415692337 0.305232571163551 no 1041 0.314304927484354 370 23734946
SGTC_1394 3474-0001 65.7 µM 0.483261725228704 0.305385594626268 no 1042 0.314454956468471 321 5017666 YIL048W NEO1
SGTC_2483 5729050 27.16 µM 0.482694616824999 0.305590954060671 no 1043 0.31465629303606 361 2865180
SGTC_1811 st050069 61.5 µM 0.482205765185318 0.305768024508433 no 1044 0.314829890885453 354 3877702
SGTC_2219 9098279 200 µM 0.481243820967408 0.306116589799598 no 1045 0.315171609800226 334 902349
SGTC_524 r073-0010 27.8 µM 0.478357986520378 0.307163339039193 no 1046 0.316197715579975 364 2772106
SGTC_3046 9092212 49.47 µM 0.477820654215945 0.307358414089454 no 1047 0.316388929629359 370 25236637
SGTC_2544 sphondin 68.51 µM 0.477673477183696 0.30741185528048 no 1048 0.316441312335423 322 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1514 1189-1591 158 µM 0.47693144193516 0.307681356639823 no 1049 0.316705470855276 372 767698 YMR146C TIF34
SGTC_2359 9039622 200 µM 0.476364765849176 0.307887238853974 no 1050 0.31690726591217 362 6463596
SGTC_629 3448-6466 76.7 µM 0.475797241462539 0.308093489899335 no 1051 0.317109417654667 362 573744
SGTC_1895 st058434 18.3 µM 0.475793927393399 0.308094694484214 no 1052 0.317110598283883 373 5393175
SGTC_1098 clofazimine 15.1 µM 0.475565244987546 0.308177820062225 no 1053 0.317192070340487 359 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2655 perillic acid 100 µM 0.474914255635261 0.308414507197107 no 1054 0.317424045043996 340 5702197 An apoptosis inducer.
SGTC_211 3455-0679 143.504 µM 0.474728269377969 0.30848214283557 no 1055 0.317490332894858 328 748649
SGTC_658 3253-0951 102 µM 0.473941117764989 0.308768469814582 no 1056 0.317770948455949 355 1184878
SGTC_1439 4092-1168 46 µM 0.473648158429513 0.30887506368994 no 1057 0.317875413718158 358 2886240
SGTC_3091 9116372 49.47 µM 0.471126607426818 0.309793200272819 no 1058 0.318775162694865 324 17169793
SGTC_617 3770-0098 35 µM 0.468479586683115 0.310758300516085 no 1059 0.319720832819864 347 5962639
SGTC_2092 5303694 80.6725 µM 0.468220100099124 0.310852979238639 no 1060 0.319813599792536 353 1963699
SGTC_2116 5511452 16.8835 µM 0.467343116799408 0.311173056298734 no 1061 0.32012720646801 368 870744
SGTC_1239 0337-0584 35.4 µM 0.466811708381852 0.31136707665605 no 1062 0.320317299135417 369 914301 YML130C ERO1
SGTC_1310 1188-0297 994 nM 0.463912739647791 0.312426428928661 no 1063 0.321355132521507 337 1588352
SGTC_2996 9066192 71.4286 µM 0.46330915902955 0.312647187178701 no 1064 0.321571390818962 330 6472854
SGTC_2433 5607874 27.82 µM 0.460603418432054 0.313637631014332 no 1065 0.322541579299701 348 2252428
SGTC_1182 1222-0449 220 µM 0.457299586120918 0.314848831466225 no 1066 0.32372786357951 352 658318
SGTC_1951 sophoraflavanone G 9.2 µM 0.456180827864246 0.315259426157594 no 1067 0.324129975422779 358 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1124 fisetin 1.16336 µM 0.456162944293492 0.315265991449627 no 1068 0.324136404927624 356 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1391 3442-0225 151 µM 0.455115706326854 0.315650547840478 no 1069 0.324512999537123 357 5227075
SGTC_2790 5423970 71.43 µM 0.450973173623256 0.317173681890916 no 1070 0.326004441826438 358 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1100 amiodarone 5.07 µM 0.449129895954416 0.317852420560187 no 1071 0.326668977638252 338 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1686 st019653 115.5 µM 0.449059141342521 0.31787848631037 no 1072 0.326694496969254 375 97252
SGTC_1285 0929-0069 65.5 µM 0.44670001365852 0.318748096644028 no 1073 0.327545835989334 336 1206237
SGTC_543 3844-1095 191 µM 0.446610792074302 0.318781004711494 no 1074 0.327578051045561 356 4230703
SGTC_2100 5377183 190 µM 0.446324800468855 0.318886498134051 no 1075 0.327681322104975 349 2844202
SGTC_1903 st060211 78.3 µM 0.44624062783141 0.318917549601782 no 1076 0.327711719205718 341 688960
SGTC_3008 9078912 71.4286 µM 0.445945726818784 0.319026349248353 no 1077 0.327818225240916 371 16648731
SGTC_2357 9067248 200 µM 0.444365683779014 0.319609549660147 no 1078 0.328389109761428 373 9150235
SGTC_1427 4048-4900 550 nM 0.442464865391202 0.320311741055125 no 1079 0.329076424688164 369 24132586
SGTC_2767 sibutramine 71.45 µM 0.441453991565246 0.320685435753969 no 1080 0.329442181174587 377 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1581 himbacine 57.9 µM 0.441157614823855 0.320795033283246 no 1081 0.329549447791053 373 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1431 4049-0260 9.09 µM 0.439765559656217 0.321310011976296 no 1082 0.330053457065122 357 3854841
SGTC_1877 wortmannin 25 µM 0.439644209125474 0.321354920851146 no 1083 0.330097408030068 381 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1967 st070177 51.4 µM 0.439343300614483 0.321466291026647 no 1084 0.330206401759434 379 5729214
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.439227292011553 0.321509231615276 no 1085 0.330248425723649 369 4620898
SGTC_571 k831-0106 44.2 µM 0.436829404734978 0.322397343156985 no 1086 0.331117536144192 379 4783639
SGTC_164 4100-3994 89.624 µM 0.436310627180685 0.32258961777543 no 1087 0.331305686226622 395 4615967
SGTC_1879 gemcitabine 100 µM 0.436071438190027 0.322678284420689 no 1088 0.331392449563975 380 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3127 9126946 49.47 µM 0.43507974357473 0.323046010181216 no 1089 0.331752273051333 390 27243249
SGTC_2328 6201408 200 µM 0.434332793318236 0.323323097665706 no 1090 0.332023396777254 365 2890418
SGTC_1792 st045773 43.6 µM 0.433467570447088 0.323644181911894 no 1091 0.332337560382429 343 2919270
SGTC_1262 0737-0114 49.6 µM 0.432336685152808 0.32406405148014 no 1092 0.332748364026468 373 765919
SGTC_2413 inermin 26.06 µM 0.431340953653297 0.324433927197595 no 1093 0.333110238246384 405 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1878 temozolomide 1 mM 0.43009020729056 0.324898776565905 no 1094 0.333565011613393 377 5394 DNA alkylating agent.
SGTC_3324 9138759 60.749 µM 0.428409461839769 0.325523867834801 no 1095 0.334176518584597 375 45595710
SGTC_2690 usnic acid 100 µM 0.428243887200263 0.325585473811546 no 1096 0.334236783595379 379 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1465 k213-0056 144 µM 0.425502196636242 0.326606276465238 no 1097 0.335235310319729 340 24048857 YMR208W ERG12
SGTC_1024 4507-0395 26 µM 0.422786050799699 0.327618849941554 no 1098 0.336225682961798 346 4201836
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.422605865695151 0.327686067539395 no 1099 0.336291423135482 387 368090
SGTC_3228 9131799 49.47 µM 0.422137558593182 0.327860794434258 no 1100 0.336462307450838 372 17015818
SGTC_382 3229-0966 23.2 µM 0.421950795559438 0.327930486841014 no 1101 0.336530466329849 378 5722370
SGTC_96 0929-0093 37.281 µM 0.419599514692745 0.328808401643745 no 1102 0.337389021481327 347 6991579
SGTC_1334 1486-0610 236 µM 0.419023431422366 0.329023642422145 no 1103 0.337599504002856 360 3742339
SGTC_1442 4112-3290 3 µM 0.418426176325953 0.329246853452967 no 1104 0.337817775686727 373 704353
SGTC_362 0310-0100 9.03 µM 0.418088300672674 0.32937315405601 no 1105 0.337941279229513 331 790235
SGTC_1419 3993-2473 62.6 µM 0.416684057537926 0.329898279781941 no 1106 0.338454758433602 370 704026
SGTC_2323 6148992 148.28 µM 0.414995320224911 0.330530238112998 no 1107 0.33907266448264 353 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2 0422-0095 29 µM 0.413636156777 0.33103921479178 no 1108 0.339570294724536 339 6790840
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.413626507084727 0.331042829506241 no 1109 0.339573828765812 384 689007
SGTC_1560 lithocholic acid 53.1 µM 0.412642355775779 0.33141156909474 no 1110 0.339934332047052 378 9903 A bile acid which acts as a detergent.
SGTC_2047 4141938 200 µM 0.412598242790419 0.331428101079198 no 1111 0.339950494452641 394 3807862
SGTC_78 0336-0123 156.75 µM 0.411403115303333 0.33187611743253 no 1112 0.340388484978659 354 6765896
SGTC_2036 5160441 105 µM 0.408826720204937 0.332842745773519 no 1113 0.341333414709684 374 134534 YIL048W NEO1
SGTC_631 k072-0230 41.5 µM 0.408765090804019 0.332865881928704 no 1114 0.341356030389543 354 5773147
SGTC_1796 st049173 110.4 µM 0.408685759388736 0.332895664494191 no 1115 0.341385142883791 389 94134
SGTC_2320 7373003 200 µM 0.408469750672068 0.332976763735902 no 1116 0.341464417052645 348 5415828
SGTC_283 0987-0079 11.7 µM 0.407802393390413 0.333227368567198 no 1117 0.3417093781672 387 411556
SGTC_2348 9022543 33.42 µM 0.407263138375153 0.333429923071942 no 1118 0.341907366591275 402 3162678 YDL140C RPO21
SGTC_3302 9125395 16.351 µM 0.407089359209844 0.33349520820489 no 1119 0.341971179183757 375 17599668
SGTC_2334 9017922 200 µM 0.40358410458173 0.334813132209031 no 1120 0.343259288208709 378 3163164
SGTC_1568 digitonin 820 nM 0.403495934069394 0.334846309353043 no 1121 0.343291712626445 397 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_128 0906-2981 13.371 µM 0.402878085571593 0.335078831947839 no 1122 0.343518956744425 370 6740226
SGTC_842 0271-0008 11.1 µM 0.400954108168507 0.335803310868211 no 1123 0.344226955934273 355 1221709
SGTC_1679 SEC14.276 6.7 µM 0.395100947704418 0.338011079618168 no 1124 0.346384194742911 405 1005053 YMR079W SEC14
SGTC_603 3794-0023 45.9 µM 0.394568470767105 0.338212204168817 no 1125 0.346580693050688 376 3802260
SGTC_482 fipronil 114 µM 0.393082849019801 0.338773589847381 no 1126 0.347129145570663 373 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_880 0833-0487 87.2 µM 0.392398488637794 0.339032316089577 no 1127 0.347381901290224 377 76075
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.391687269363722 0.339301276953295 no 1128 0.347644648771599 349 6857784
SGTC_650 1328-0195 38 µM 0.389937642352018 0.339963279417048 no 1129 0.348291329093127 396 2780821
SGTC_762 1165-0429 115 µM 0.388850549049567 0.340374849335993 no 1130 0.348693352479666 403 5967793
SGTC_3244 9134489 49.47 µM 0.388164167727753 0.340634809020329 no 1131 0.348947274141726 394 16584271
SGTC_2202 7226349 200 µM 0.387359984198179 0.340939481370693 no 1132 0.349244861922791 350 844334
SGTC_1413 3910-0535 34.4 µM 0.387025582224525 0.341066203200447 no 1133 0.349368634536329 388 2876951
SGTC_595 3909-8003 73.7 µM 0.386745219289213 0.341172460722736 no 1134 0.349472417960585 385 699517
SGTC_1574 spiramycin 23.7 µM 0.386334728874596 0.34132805926605 no 1135 0.349624391658091 374 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1687 st020778 55.3625 µM 0.386026015659772 0.341445096404117 no 1136 0.349738700801454 364 4259299
SGTC_2785 7756463 72.73 µM 0.385711793286827 0.341564237794521 no 1137 0.349855063844692 394 2201551
SGTC_3184 9108758 49.47 µM 0.385210963638741 0.341754166327246 no 1138 0.350040560572165 380 902885
SGTC_834 0312-0008 75.7 µM 0.384833705719967 0.341897259482345 no 1139 0.350180312576029 378 6385573 YIL048W NEO1
SGTC_1458 k015-0034 6.33 µM 0.383466717486535 0.342415945461639 no 1140 0.35068687164411 380 3598957
SGTC_2387 9077560 195.08 µM 0.382804649712973 0.342667265450272 no 1141 0.350932306829776 365 5303272
SGTC_2489 cantharidin 73.42 µM 0.382020742596673 0.342964925540888 no 1142 0.351222989516637 380 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2929 9013348 24.6 µM 0.380432677827795 0.343568233762905 no 1143 0.351812130727738 372 2995952
SGTC_3172 9105863 49.47 µM 0.378716875446796 0.344220517813914 no 1144 0.352449060223085 388 2348785
SGTC_1515 3460-0031 42.1 µM 0.378291550905843 0.34438228213215 no 1145 0.352607010652184 389 2876596
SGTC_964 1287-0107 19.4 µM 0.378243838131244 0.344400430579584 no 1146 0.352624731068087 385 51516812 YPR165W RHO1
SGTC_568 1193-0097 7.48 µM 0.376184171987746 0.345184204206626 no 1147 0.353389990799788 374 3646150
SGTC_3035 9091303 49.47 µM 0.376154719380631 0.345195416760987 no 1148 0.35340093809238 376 25237002
SGTC_1326 1431-2094 10.8 µM 0.375688930469992 0.345372759821247 no 1149 0.353574084132311 408 616278
SGTC_1782 st039423 80.636 µM 0.373577869704512 0.346176943860361 no 1150 0.354359200579802 381 2068169
SGTC_1871 st057448 67.3 µM 0.373222236594969 0.346312486569374 no 1151 0.354491523760732 414 691747
SGTC_1113 artemisinin 1.17947 µM 0.37179090928877 0.346858208299544 no 1152 0.355024266317076 393 2240 An anti-malaria and mitochondrial poison.
SGTC_1662 st014054 52 µM 0.371769434169209 0.346866398534844 no 1153 0.355032261556192 397 2838777
SGTC_569 4130-2812 160 µM 0.37174394530228 0.346876119636109 no 1154 0.355041751206035 391 743552
SGTC_1956 st077085 54 µM 0.371522753510569 0.346960483357773 no 1155 0.355124105940982 413 24208685
SGTC_927 2425-1185 123 µM 0.370939750089907 0.347182880294196 no 1156 0.355341203793921 403 730375
SGTC_2596 sinensetin 100 µM 0.370287607155358 0.347431714086377 no 1157 0.355584103339402 374 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_961 1252-1571 372 µM 0.36973988207616 0.34764075667923 no 1158 0.355788156357185 409 6813498
SGTC_750 4073-0104 132 µM 0.369205158983187 0.347844881685384 no 1159 0.35598740540015 384 22330957
SGTC_2493 resveratrol 26.09 µM 0.368997598231098 0.347924127741103 no 1160 0.356064757492678 361 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1723 st034307 2.5525 µM 0.367699813162239 0.348419768580999 no 1161 0.356548539941036 372 867466
SGTC_2659 sanguinarine 24.21 µM 0.366815063686159 0.348757814296369 no 1162 0.356878485263951 390 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2080 5212524 12.4 µM 0.366290616996089 0.348958251980664 no 1163 0.357074115191092 386 260183
SGTC_2848 9016370 25.97 µM 0.365396083145015 0.349300230098453 no 1164 0.357407882311441 388 7894410
SGTC_1632 st005650 90 µM 0.364445635850231 0.349663717888552 no 1165 0.357762631322286 360 2759605
SGTC_3101 9120531 49.47 µM 0.364386506896675 0.349686335644791 no 1166 0.357784704929309 424 24824904
SGTC_3320 9137005 35.139 µM 0.363011115980401 0.350212594730024 no 1167 0.358298290294867 397 4908713
SGTC_1556 plumbagin 1.48 µM 0.363009240327976 0.350213312598411 no 1168 0.358298990858436 396 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1987 st072290 61.9 µM 0.362277644160341 0.350493357166111 no 1169 0.358572281265654 408 54697379
SGTC_1203 3992-3522 103 µM 0.361446448795772 0.350811625513457 no 1170 0.35888286521541 419 5322312
SGTC_2226 7298446 200 µM 0.360095623136737 0.351329085878044 no 1171 0.359387812892524 409 3283010
SGTC_2997 9067075 71.4286 µM 0.358971166725336 0.351760041372246 no 1172 0.359808329636525 424 27209819
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.357094646162304 0.352479654633311 no 1173 0.360510476180634 397 756377
SGTC_2540 epiandrosterone 100 µM 0.356429670673612 0.352734788179682 no 1174 0.360759406250408 391 441302 A steroid.
SGTC_2993 9054257 71.4286 µM 0.355968342326874 0.352911826621619 no 1175 0.360932136759892 391 6470217 YGL055W OLE1
SGTC_1859 st055998 20 µM 0.355895496554095 0.352939784682112 no 1176 0.36095941426041 383 676301
SGTC_1851 st056236 18.9 µM 0.354511115278978 0.353471258198389 no 1177 0.361477937728831 386 5393171
SGTC_178 4092-0806 87.505 µM 0.352772658876036 0.354139068340462 no 1178 0.362129441339219 383 2169044
SGTC_1832 st054113 55 µM 0.352464959898588 0.354257314548965 no 1179 0.362244796233101 402 1251267
SGTC_561 1550-0330 72.9 µM 0.351074522519702 0.354791823377032 no 1180 0.362766220508481 398 6812934
SGTC_421 streptovitacin 30 mM 0.348347168219694 0.355841096643418 no 1181 0.363789737139856 380 91467 include heat shock
SGTC_3211 9128781 49.47 µM 0.347250277368701 0.356263403369583 no 1182 0.364201651063586 402 17194361
SGTC_1518 st038567 90.8 µM 0.346646113307662 0.35649608394956 no 1183 0.364428599017568 411 77966
SGTC_795 0685-0265 78 µM 0.346395194835188 0.356592735420073 no 1184 0.36452286791016 392 302754
SGTC_2442 5158906 48.48 µM 0.346354852904266 0.356608275617569 no 1185 0.364538024949027 397 1893835
SGTC_1329 1447-1697 50.6 µM 0.346184718516561 0.356673816050587 no 1186 0.364601949194907 380 2840515
SGTC_1809 st050081 57.6 µM 0.345932746794463 0.356770890244089 no 1187 0.364696628932068 416 5036894
SGTC_3336 9143619 71.43 µM 0.345795939988932 0.356823600085402 no 1188 0.364748038286363 384 45595730
SGTC_1808 st050063 61.5 µM 0.345684365267667 0.356866590364463 no 1189 0.364789967711545 427 4011993
SGTC_3338 9144300 39.5675 µM 0.345299799532926 0.357014779327217 no 1190 0.364934498681251 370 4901274
SGTC_893 0958-0369 48.9 µM 0.343535726137298 0.357694825388157 no 1191 0.365597734358533 419 6819948
SGTC_1327 1436-0082 2.18 µM 0.343260486803687 0.357800970307232 no 1192 0.365701251928606 401 15992205
SGTC_874 0599-0792 117 µM 0.342943529638297 0.357923217159773 no 1193 0.365820471700071 420 765305
SGTC_1082 camptothecin 424.86 nM 0.341418505080513 0.358511605687437 no 1194 0.366394273046062 446 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2618 avocadyne 43.43 µM 0.34137512123731 0.358528349065121 no 1195 0.366410600903104 411 3015189
SGTC_2818 7996756 12.99 µM 0.340558523633253 0.35884355400548 no 1196 0.366717979038203 410 2241621
SGTC_3072 9116419 49.47 µM 0.339992001894127 0.359062286697891 no 1197 0.366931275552152 375 17170162
SGTC_1448 4255-0083 152 µM 0.339531391205803 0.359240161450893 no 1198 0.367104726640151 415 5399660
SGTC_634 1611-4317 11.2 µM 0.339509459091234 0.359248631771373 no 1199 0.367112986242037 418 2843522
SGTC_2206 7254556 146.969 µM 0.339450081680937 0.359271564047551 no 1200 0.367135347995513 384 4398905
SGTC_2446 5162541 200 µM 0.338543116558717 0.359621907950607 no 1201 0.367476970413001 394 1549321
SGTC_32 0928-0142 34.1 µM 0.336657329405187 0.360350730246131 no 1202 0.368187616814876 416 2244242
SGTC_255 tunicamycin 200.472 nM 0.336391171683561 0.360453636293457 no 1203 0.368287952985074 387 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1923 st058458 19.1 µM 0.336260098922958 0.360504317402669 no 1204 0.368337368112136 425 3534982
SGTC_2810 7959871 45.46 µM 0.335992108220401 0.360607947368941 no 1205 0.36843840880884 387 2974535
SGTC_630 4356-0227 183 µM 0.33470831983269 0.361104520447266 no 1206 0.368922562396576 408 779312
SGTC_1220 1838-0075 193 µM 0.3336558696261 0.361511785964653 no 1207 0.369319626939602 399 5529645
SGTC_645 0845-0943 5.41 µM 0.331749630909621 0.362249840432043 no 1208 0.370039160445279 395 1885106
SGTC_3080 9117754 49.47 µM 0.331209597824778 0.362459022839806 no 1209 0.37024308548919 407 9550191
SGTC_1456 k015-0012 13 µM 0.330372025540656 0.362783538608127 no 1210 0.370559438188932 406 2989616
SGTC_1810 st050138 53 µM 0.329455440819299 0.363138780554387 no 1211 0.370905734362904 432 3444541
SGTC_361 000s-0510 1.45 µM 0.32918733920866 0.36324271132421 no 1212 0.371007045994508 376 660
SGTC_3163 9099914 49.47 µM 0.328969088785959 0.363327324497068 no 1213 0.371089526202469 432 16268368
SGTC_789 1309-1135 70.6 µM 0.328020503824306 0.363695157389126 no 1214 0.371448079880327 391 3092424
SGTC_3169 9102970 49.47 µM 0.325861268640272 0.364532912381534 no 1215 0.372264660363313 397 17027839
SGTC_1539 benzyladenosine 56 µM 0.3250583856108 0.364844585833601 no 1216 0.372568441783324 360 92208 A nucleotide analog.
SGTC_148 3253-0744 288.01 µM 0.325039633681133 0.36485186626702 no 1217 0.372575537772361 389 6893655
SGTC_2324 6149169 200 µM 0.324058992111628 0.365232668037017 no 1218 0.372946686298661 432 2888231
SGTC_1912 st060209 90.8 µM 0.32397132942419 0.365266715603138 no 1219 0.372979870201575 438 688787
SGTC_3029 9088683 49.47 µM 0.322426388893029 0.365866933606367 no 1220 0.373564847665851 373 25236615
SGTC_1200 1643-0193 18.4 µM 0.320096021015184 0.366772915531078 no 1221 0.374447770939971 425 5403974
SGTC_2953 9074162 66.49 µM 0.319103576342016 0.367158976083921 no 1222 0.374823985899302 431 16451992
SGTC_301 4119-0100 24.5 µM 0.318350990905692 0.367451821088322 no 1223 0.375109354714408 426 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2541 muurolladie-3-one 83.07 µM 0.316066999298331 0.368341036171608 no 1224 0.375975827233882 437 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_921 1561-0023 372 µM 0.314884899808635 0.368801534523766 no 1225 0.376424523522733 402 24050882
SGTC_1626 st003712 1.76 µM 0.313501919495449 0.369340527109168 no 1226 0.376949681298302 418 24207035
SGTC_182 3448-4371 550.524 µM 0.310725430210485 0.370423390409539 no 1227 0.378004681529814 380 3491403
SGTC_698 k064-0052 127 µM 0.310330892728728 0.370577348222795 no 1228 0.3781546704968 422 5088751
SGTC_598 3937-0236 20.2 µM 0.31006303427722 0.370681884711833 no 1229 0.378256511118711 413 1379313
SGTC_3038 9091290 49.47 µM 0.309837076701714 0.370770076068823 no 1230 0.378342427473917 441 25236843
SGTC_1545 lovastatin 49.4 µM 0.309534493233434 0.370888185184322 no 1231 0.378457488884195 392 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2133 5320837 200 µM 0.308083297535043 0.371454807512232 no 1232 0.379009475078509 409 2841355
SGTC_2054 5233173 129 µM 0.306615773859562 0.372028088544798 no 1233 0.379567922907697 381 6889
SGTC_977 1348-1378 135 µM 0.30655074777249 0.372053497246981 no 1234 0.379592673597208 431 X977
SGTC_2971 9092186 9.93 µM 0.303864788188087 0.373103511592952 no 1235 0.380615452517694 352 25236400
SGTC_1893 st059353 36.1 µM 0.303527230625938 0.373235538864613 no 1236 0.380744049311467 434 3112488
SGTC_2186 6124449 200 µM 0.303446772808582 0.373267010142525 no 1237 0.380774702672826 426 3834182 YLR033W RSC58
SGTC_262 fenpropimorph 62.5 µM 0.30287469960466 0.373490802383259 no 1238 0.380992676544413 418 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2453 5731132 22.18 µM 0.302428850209452 0.373665246079506 no 1239 0.381162582252852 418 1362040
SGTC_1875 nocodazole 6 µM 0.301477604733036 0.374037518289049 no 1240 0.381525162459847 412 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3102 9121669 49.47 µM 0.300016469133492 0.37460956599912 no 1241 0.382082296699719 410 41905072
SGTC_3221 9128209 49.47 µM 0.299477592483392 0.37482061079884 no 1242 0.382287833276999 410 16460723
SGTC_409 arachidonic acid 100 µM 0.299308830598433 0.374886712149478 no 1243 0.382352208709332 399 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_299 1273-0059 1.44 µM 0.298855616512041 0.375064247095505 no 1244 0.382525106563454 401 2848077
SGTC_1320 1313-0481 95.3 µM 0.298628730198924 0.375153133911459 no 1245 0.382611670828839 416 6813365 YLR208W SEC13
SGTC_1986 st071812 45 µM 0.297981595175781 0.375406697169701 no 1246 0.382858605405491 438 11838594
SGTC_1602 st001878 87.6 µM 0.297272163009982 0.37568473182313 no 1247 0.383129366118141 436 595405 YLR310C CDC25
SGTC_2832 7992762 51.95 µM 0.296640349349186 0.375932401250877 no 1248 0.383370551161285 351 2985177
SGTC_443 clozapine 122 µM 0.295828566384509 0.376250693229527 no 1249 0.383680503033432 452 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2603 homopterocarpin 100 µM 0.295085357946202 0.376542171645272 no 1250 0.383964337322593 405 101795 A weak amylase inhibitor.
SGTC_2566 crystal violet carbinol 226 nM 0.294900596351395 0.376614644103786 no 1251 0.384034908185635 451 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1273 0849-0096 14.1 µM 0.294632939184149 0.376719639939149 no 1252 0.384137148357875 425 5286025
SGTC_1596 piperlongumine 63 µM 0.29429744612533 0.376851259134584 no 1253 0.384265311994015 386 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_451 chloral hydrate 100 µM 0.29341785521891 0.377196404381561 no 1254 0.38460138963184 425 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3341 9147222 25.867 µM 0.293164530479861 0.3772958254287 no 1255 0.384698197069018 419 1939759
SGTC_3006 9075424 71.4286 µM 0.292930925628549 0.377387514322269 no 1256 0.38478747497087 424 7465181
SGTC_690 glyoxal 20.3 µM 0.292481219154288 0.377564041623509 no 1257 0.384959358678069 406 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2048 5246248 200 µM 0.292314565710604 0.377629466087039 no 1258 0.385023061551521 417 677046
SGTC_2015 5119600 184 µM 0.292196604209146 0.377675777291108 no 1259 0.385068153924343 438 2828786
SGTC_3314 9135860 59.4275 µM 0.291680514906843 0.377878412513641 no 1260 0.38526545427935 434 25252478
SGTC_1378 2093-0007 380 nM 0.291507914701284 0.377946189064349 no 1261 0.385331445772511 440 3618014
SGTC_2221 6807166 181.081 µM 0.291450741776222 0.37796864052457 no 1262 0.385353305845365 416 674925
SGTC_124 0136-0217 7.121 µM 0.290958568523628 0.378161931008627 no 1263 0.385541503389134 403 3976905
SGTC_1474 0330-0125 5.35 µM 0.290924030892199 0.378175496068012 no 1264 0.385554710924694 400 X1474
SGTC_3219 9131112 49.47 µM 0.290400195389478 0.378381257001685 no 1265 0.385755047120287 395 17612988 YMR079W SEC14
SGTC_1727 st034309 9.9045 µM 0.288620395087126 0.379080614300163 no 1266 0.386435943195019 441 870305
SGTC_2910 7948405 25.97 µM 0.28860792763988 0.379085514676162 no 1267 0.386440714087674 437 2971328
SGTC_1728 st035614 33.7865 µM 0.287505441067275 0.379518927830231 no 1268 0.386862668179872 406 15945546
SGTC_2624 nerol 100 µM 0.286601890564035 0.379874247523667 no 1269 0.387208583338203 425 637566 A natural product oil.
SGTC_2731 amoxapine 43.43 µM 0.284941623326466 0.38052740902722 no 1270 0.38784443319908 442 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1712 st032288 53.4 µM 0.284772218333256 0.380594073401846 no 1271 0.387909328939635 425 2883011
SGTC_2459 5811157 9.22 µM 0.284469116696193 0.38071335902233 no 1272 0.388025449061218 412 2870684 YBR192W RIM2
SGTC_296 1222-0039 74.9 µM 0.28412999452413 0.380846833962711 no 1273 0.388155380741466 403 5984176
SGTC_1620 st003704 16.5 µM 0.283329245207418 0.381162056769235 no 1274 0.388462230465294 428 2834414
SGTC_384 k007-0144 5.16 µM 0.282776737493981 0.38137960283552 no 1275 0.388673993809749 416 6824886
SGTC_2515 chrysin 20.77 µM 0.28264247283682 0.381432474273576 no 1276 0.388725459326781 391 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3044 9093193 49.47 µM 0.281257661127226 0.381977921599137 no 1277 0.389256390785208 436 25236277
SGTC_1608 st001473 40.5 µM 0.280697008279176 0.382198817316329 no 1278 0.389471401793511 454 7292267
SGTC_1800 st050079 29.0735 µM 0.279943829136188 0.382495628227421 no 1279 0.389760300110434 421 3645560
SGTC_307 1501-1223 22.3 µM 0.276099947271923 0.38401148723224 no 1280 0.391235650585401 428 2830329
SGTC_2144 5628481 200 µM 0.275843263142191 0.3841127757535 no 1281 0.391334226559606 429 2818399
SGTC_470 aa-861 153 µM 0.275823691167941 0.384120499252886 no 1282 0.391341743190897 392 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2077 5212015 200 µM 0.275654794886643 0.384187151074683 no 1283 0.39140660961924 437 780900
SGTC_928 2764-0428 58.7 µM 0.275528761934628 0.384236889900765 no 1284 0.39145501589398 436 662578
SGTC_3012 9080433 71.4286 µM 0.274888587259344 0.38448956385637 no 1285 0.391700917778503 443 17688859
SGTC_58 0957-0393 9 µM 0.274757485694501 0.384541315090585 no 1286 0.391751281441481 409 6997992
SGTC_2305 7443522 69.23 µM 0.274315900962987 0.384715642062552 no 1287 0.391920932915585 428 5415886
SGTC_811 0416-0114 265 µM 0.273339705248446 0.385101103203697 no 1288 0.392296048307606 436 6612453
SGTC_1578 josamycin 24.2 µM 0.273162506504618 0.385171084179558 no 1289 0.392364149881969 396 5282165 A P450 substrate.
SGTC_71 0417-1750 47.813 µM 0.271614843255879 0.385782460484403 no 1290 0.392959092565203 449 6811472
SGTC_183 3914-0051 30.55 µM 0.270594541748353 0.386185667436032 no 1291 0.393351447159295 426 1596232
SGTC_1603 st002045 67.8 µM 0.270449467744743 0.386243008372301 no 1292 0.393407243839351 428 5887985
SGTC_2063 5246145 200 µM 0.269301339783469 0.386696896950389 no 1293 0.393848900628046 436 711240
SGTC_705 1124-0212 310 µM 0.268746207215177 0.386916412738502 no 1294 0.394062495587029 461 9554485
SGTC_2725 haloperidol 53.21 µM 0.266976066106548 0.387616620021967 no 1295 0.394743794468566 442 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3289 9119912 71.43 µM 0.266684627436113 0.387731938312224 no 1296 0.394855995460875 422 17014829
SGTC_1981 st071826 47 µM 0.265569563175772 0.388173245318716 no 1297 0.395285364559191 407 11838600
SGTC_1817 st052116 64.4 µM 0.264891815916398 0.388441546760974 no 1298 0.395546401578663 408 4361398
SGTC_2580 diallyl disulphide 81.36 µM 0.264768355440418 0.388490427093404 no 1299 0.395593957915711 402 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.264344669277069 0.388658185865722 no 1300 0.395757171452663 446 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2765 myclobutanil 7.74 µM 0.264091294178226 0.388758519802564 no 1301 0.395854786034688 445 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2229 7354935 190 µM 0.262669274578948 0.389321762475332 no 1302 0.39640275036516 447 318112
SGTC_3347 9188721 44.724 µM 0.260405188589447 0.39021901580629 no 1303 0.397275620533574 453 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_744 1594-0068 283 µM 0.259433606026346 0.390604231985362 no 1304 0.397650351608043 414 668392
SGTC_1966 st070145 16.1 µM 0.259239686570446 0.390681130663947 no 1305 0.39772515600113 422 3748532
SGTC_1104 tacrolimus 29.8 µM 0.257831158943438 0.391239809840759 no 1306 0.398268607959102 422 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1816 st051957 91.6 µM 0.255359944439761 0.392220535493037 no 1307 0.399222552561685 453 674121
SGTC_1109 tnp00067 928.257 nM 0.255231744911938 0.392271431473128 no 1308 0.399272056951231 436 676295
SGTC_3252 9135871 49.47 µM 0.255032151705565 0.392350674838923 no 1309 0.399349133312622 439 17682838
SGTC_599 1935-0052 86.5 µM 0.252914650987883 0.393191648496114 no 1310 0.40016708380596 425 9557311
SGTC_3115 9123671 49.47 µM 0.250154615231513 0.394288555539653 no 1311 0.401233890692356 419 3286988
SGTC_391 gliotoxin 8.33 µM 0.247379646743777 0.395392243042521 no 1312 0.402307212158493 431 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2916 7875993 68.79 µM 0.246734223898114 0.395649067577478 no 1313 0.402556959197723 446 1299250
SGTC_2746 daunorubicin 9.88 µM 0.246145853317495 0.395883229552372 no 1314 0.402784664462753 446 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_460 trequinsin 123 µM 0.245533126156534 0.396127124997272 no 1315 0.403021831021408 443 5537 A vasodilator.
SGTC_99 0109-0120 622.8 µM 0.240693758184492 0.398054852243506 no 1316 0.404896238510547 453 759414
SGTC_3256 9138902 49.47 µM 0.239069043356981 0.398702606591701 no 1317 0.40552602282863 453 17228773
SGTC_873 0591-4978 488 µM 0.237201224178508 0.399447628562564 no 1318 0.406250343328114 470 3305145
SGTC_3123 9126162 49.47 µM 0.236473868663631 0.399737850030028 no 1319 0.406532491060826 416 25239884
SGTC_3262 9137218 49.47 µM 0.236467453510732 0.399740409981092 no 1320 0.406534979772341 440 17650664
SGTC_2284 7945075 39.21 µM 0.236124165590613 0.399877404468364 no 1321 0.40666816130698 456 1245402
SGTC_1998 st075797 76.8 µM 0.236052292572681 0.399906088096517 no 1322 0.406696046436727 459 24208315
SGTC_2507 purpurin 79.67 µM 0.235362937690503 0.400181228472625 no 1323 0.406963524783139 432 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1078 idebenone 36.1 µM 0.23412449770256 0.400675648114237 no 1324 0.407444163986765 444 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3048 9093155 49.47 µM 0.233933947940921 0.400751735020402 no 1325 0.407518128838456 455 25236002
SGTC_2727 riluzole 51.77 µM 0.232831951533587 0.40119183819277 no 1326 0.407945950464833 441 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_667 1498-1044 59 µM 0.232280636073943 0.401412063578155 no 1327 0.408160025675991 466 6739982
SGTC_3241 9133421 49.47 µM 0.231958647425337 0.401540697852447 no 1328 0.408285066214252 462 17018221
SGTC_36 0335-0881 14.2 µM 0.231771017792152 0.401615660701025 no 1329 0.408357934302673 430 23828853
SGTC_2044 5102272 200 µM 0.231370019542565 0.401775881915883 no 1330 0.408513677124696 428 592666
SGTC_1826 st055655 41.6 µM 0.230952933578733 0.401942548589616 no 1331 0.408675683549648 433 676168
SGTC_1153 4055-0057 267 µM 0.230898184660053 0.401964427467081 no 1332 0.408696950532689 439 882706
SGTC_1260 0700-1617 7.75 µM 0.230703949926348 0.402042050435776 no 1333 0.408772402351731 439 2853078
SGTC_1718 roemerine 11.9335 µM 0.230269682853837 0.402215612664386 no 1334 0.408941108611094 434 235224 An aporphine alkaloid with mutagenic activity.
SGTC_676 falcarinol 140 µM 0.23022630725716 0.402232949519701 no 1335 0.408957960308559 452 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2188 6126565 140.678 µM 0.230083686535526 0.40228995515901 no 1336 0.409013370559691 448 874518
SGTC_1430 4049-0248 69.1 µM 0.229966920543417 0.402336628185367 no 1337 0.409058737221353 451 22774488
SGTC_550 4123-0385 25.7 µM 0.229939018117226 0.402347781387759 no 1338 0.409069578228783 439 5731123
SGTC_2645 abamectin 100 µM 0.229740479949232 0.402427143676337 no 1339 0.409146718824388 444 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1247 0448-0043 5.84 µM 0.229402602182591 0.40256221386692 no 1340 0.409278006919651 440 3089013 YGL099W LSG1
SGTC_3103 9120822 49.47 µM 0.228087492681212 0.40308805333096 no 1341 0.409789111620015 476 17141819
SGTC_2801 7907800 81.82 µM 0.227765460925184 0.403216842753332 no 1342 0.409914289577554 472 6620925
SGTC_1366 1683-0113 21.9 µM 0.22729823198619 0.403403719215393 no 1343 0.41009592390181 410 708623
SGTC_1433 4060-0023 7.6 µM 0.226187880106664 0.403847912478713 no 1344 0.410527648320068 438 3840627
SGTC_1075 aripiprazole 15.2 µM 0.225508967475939 0.404119570778698 no 1345 0.410791674994916 416 60795 An atypical antipschotic. YIL048W NEO1
SGTC_45 0kpi-0036 14.9 µM 0.225452887992901 0.404142012343811 no 1346 0.41081348591284 466 2795021
SGTC_65 0798-0905 34.986 µM 0.225348227616588 0.404183895575199 no 1347 0.410854192069779 472 3602145
SGTC_174 3553-0389 74.3 µM 0.224596610304017 0.40448471176702 no 1348 0.411146551055804 417 738071
SGTC_620 0109-0052 432 µM 0.224320469415077 0.40459524450487 no 1349 0.411253974865402 459 493037
SGTC_1772 st048439 82.2 µM 0.223270513042934 0.405015586921506 no 1350 0.41166248760666 447 2927068 YDL195W SEC31
SGTC_2318 6029776 164 µM 0.22121230589645 0.405839892832002 no 1351 0.412463563941986 450 818325
SGTC_2016 5121758 140 µM 0.219894327560959 0.406367958878354 no 1352 0.412976727074998 460 2795203
SGTC_1628 st004252 77.7 µM 0.219863585772531 0.40638027803304 no 1353 0.412988698361662 423 692968
SGTC_2766 oltipraz 83.91 µM 0.2193045397577 0.406604320656778 no 1354 0.413206412880984 421 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2110 5483698 200 µM 0.219228045096343 0.406634978947003 no 1355 0.413236204990148 415 2848765 YHR062C RPP1
SGTC_677 0929-0063 136 µM 0.218260863084934 0.407022665061951 no 1356 0.413612933035524 455 1539583
SGTC_325 2810-4341 181 µM 0.211687056826523 0.409660111249765 no 1357 0.41617559321502 448 774970
SGTC_2337 9009472 200 µM 0.211682764382928 0.409661834751254 no 1358 0.416177267711296 467 5742383
SGTC_756 0508-1999 28.3 µM 0.211518060366034 0.409727968008597 no 1359 0.416241520435601 428 6753853
SGTC_2890 9046729 58.44 µM 0.210523308069307 0.410127443340165 no 1360 0.41662963102412 438 903329
SGTC_2706 st078239 82.5 µM 0.209689231876161 0.410462465844041 no 1361 0.416955115209101 470 15434492
SGTC_81 0411-0046 9.971 µM 0.208020456867289 0.411132956872815 no 1362 0.417606497229797 433 12925265
SGTC_1710 st031758 61.5 µM 0.207153326800427 0.411481460554699 no 1363 0.417945058223042 466 5394341
SGTC_1064 honokiol 6.76 µM 0.206675885362525 0.411673376367104 no 1364 0.418131495737507 453 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_290 2043-6722 48.1 µM 0.206492692093899 0.411747019670264 no 1365 0.418203036303084 457 773758 YLR208W SEC13
SGTC_203 k066-0004 30.888 µM 0.206422186492741 0.411775363600125 no 1366 0.418230570844973 465 6795412
SGTC_1270 0831-1170 17.3 µM 0.2058430299037 0.412008207528394 no 1367 0.418456763935133 458 6764716
SGTC_219 mitoxanthrone 164.414 µM 0.20482290922306 0.412418411816537 no 1368 0.418855243742244 443 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1708 st033234 31.827 µM 0.204465536055498 0.412562139043849 no 1369 0.418994860657983 425 674664
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.204199417141992 0.412669173536955 no 1370 0.419098833406946 446 15053
SGTC_718 1130-0073 349 µM 0.204050628884423 0.412729019824747 no 1371 0.41915696749228 450 6740020
SGTC_2893 9048488 25.97 µM 0.203568703170452 0.412922876091185 no 1372 0.419345276119189 429 6467338
SGTC_1046 2001-0062 216 µM 0.203552791460315 0.41292927699342 no 1373 0.41935149380824 457 739778
SGTC_1092 toremifene 6.32 µM 0.203057934382405 0.413128357763602 no 1374 0.419544875112795 475 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3076 9116187 49.47 µM 0.20289791983836 0.413192736321986 no 1375 0.419607410097643 465 27241210
SGTC_1003 4049-0218 100 µM 0.202102988163288 0.41351259529023 no 1376 0.419918105926793 471 295161
SGTC_2207 7258803 200 µM 0.201075330541456 0.413926181916852 no 1377 0.420319835704503 458 3666799
SGTC_540 1187-0821 17.3 µM 0.200044754879194 0.414341038823514 no 1378 0.4207227895707 488 847520
SGTC_1915 st067105 30.6 µM 0.198051816007279 0.415143564557688 no 1379 0.421502261632161 473 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1461 k072-0203 53.8 µM 0.197887632854399 0.415209694416876 no 1380 0.421566490197221 466 5418714
SGTC_2079 5212404 121 µM 0.197373413120997 0.415416827905397 no 1381 0.421767666814546 434 758462
SGTC_1227 3909-8010 46.6 µM 0.196441993042808 0.415792074198127 no 1382 0.422132115404043 451 15982272
SGTC_484 loperamide 105 µM 0.195648753488168 0.416111711513462 no 1383 0.422442548935778 438 3955 An opioid-receptor agonist.
SGTC_144 4161-2749 112.381 µM 0.192531238716894 0.417368455429986 no 1384 0.423663050326773 449 797501 YMR168C CEP3
SGTC_29 0299-0004 12.984 µM 0.192240407517895 0.417485739631794 no 1385 0.423776947760313 484 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1978 st071761 42 µM 0.190252473593893 0.418287614621033 no 1386 0.424555646977176 429 5147680
SGTC_717 1532-0246 73.2 µM 0.18978726388942 0.41847531592468 no 1387 0.424737918227533 433 9561992
SGTC_385 1494-0393 12.4 µM 0.18922384458981 0.418702667371341 no 1388 0.424958689982962 460 3090647
SGTC_3245 9134821 49.47 µM 0.188997508773163 0.418794006247516 no 1389 0.425047384657765 452 17014901
SGTC_2163 5671233 125 µM 0.188896742062845 0.418834672532883 no 1390 0.425086873533473 433 701023
SGTC_588 3970-1144 52.9 µM 0.186021970473496 0.419995203916564 no 1391 0.426213766043397 456 1888707
SGTC_95 0471-0001 561.058 µM 0.186016648475863 0.419997353029813 no 1392 0.426215852795006 430 4015405
SGTC_2977 9011197 71.43 µM 0.185274352452153 0.420297128144244 no 1393 0.426506926767565 507 2704722
SGTC_2431 5490079 200 µM 0.185174860550672 0.420337311314448 no 1394 0.426545943228708 466 5722345
SGTC_3251 9135047 49.47 µM 0.182394318274164 0.421460661748449 no 1395 0.427636642190472 469 17682963
SGTC_2961 9083290 32.55 µM 0.182215477826682 0.421532936006566 no 1396 0.427706813391218 478 17741490
SGTC_2678 equilin 100 µM 0.179441699508943 0.42265423178041 no 1397 0.42879544561953 464 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2311 7694451 200 µM 0.178103451713782 0.423195441265276 no 1398 0.429320865649279 489 2163142
SGTC_253 dyclonine 31.25 µM 0.175911347119461 0.42408227728769 no 1399 0.430181795327403 437 3180 An oral anasthetic.
SGTC_379 3970-0972 5.9 µM 0.175718042053683 0.424160499141848 no 1400 0.430257730171234 450 2898042 YBL034C STU1
SGTC_2024 5144227 134 µM 0.175230645305342 0.424357739911474 no 1401 0.430449202692125 457 3475211
SGTC_2943 9068529 45.32 µM 0.1747541791207 0.424550575590357 no 1402 0.430636396978095 493 3270634
SGTC_2563 tomatine 8.54 µM 0.172891828285495 0.425304480170558 no 1403 0.431368227505271 491 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1333 1482-0047 286 µM 0.171671340400686 0.425798698397096 no 1404 0.431847959161373 493 3811116
SGTC_2499 avocadenofuran 51.48 µM 0.171211868486742 0.425984784892036 no 1405 0.432028587792761 446 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2907 7721985 69.9 µM 0.16991671557621 0.426509411447213 no 1406 0.432537817575818 451 3267881
SGTC_1306 1185-0270 9.02 µM 0.169580139955943 0.426645769193275 no 1407 0.432670171165055 476 1548076
SGTC_414 piperonyl butoxide 100 µM 0.169501011419126 0.426677828014296 no 1408 0.43270128843727 475 5794 A potent inhibitor of cytochrome P450.
SGTC_2939 9044578 71.43 µM 0.169385976097332 0.42672443528523 no 1409 0.432746526785744 454 2653634
SGTC_796 1234-0020 70.7 µM 0.166480648647054 0.427901884163825 no 1410 0.433889355400019 442 46495034
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.164254140244205 0.428804661761826 no 1411 0.434765541031952 474 688751
SGTC_870 0573-2213 57.6 µM 0.164196175991646 0.428828169400188 no 1412 0.434788355684855 479 3916321
SGTC_2304 7443016 91.4 µM 0.164124079443969 0.428857408800615 no 1413 0.434816733093363 492 939854
SGTC_876 0720-0963 56.8 µM 0.163941651397969 0.428931395871561 no 1414 0.434888538796356 483 765861
SGTC_1043 0916-0009 19.3 µM 0.163153930079791 0.42925089947358 no 1415 0.435198619274863 494 3101130
SGTC_2775 cyproheptadine 69.59 µM 0.162756468551767 0.429412129413579 no 1416 0.435355092108271 487 2913 A selective serotonin reuptake inhibitor.
SGTC_2606 farnesol 9.78 µM 0.162512179522659 0.429511230900833 no 1417 0.435451268947525 485 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_12 0849-0099 9.267 µM 0.161635317909897 0.42986698661468 no 1418 0.435796521667089 490 6071388
SGTC_2462 5162487 171.77 µM 0.161070553573748 0.430096150022909 no 1419 0.436018916117502 477 2259986
SGTC_2025 5147754 141 µM 0.160744081193573 0.430228632879465 no 1420 0.436147484539762 481 315777 YLR208W SEC13
SGTC_3 0833-0587 95.581 µM 0.160689380389768 0.430250831295461 no 1421 0.436169026979634 456 5382644
SGTC_2089 5281248 129.67 µM 0.159858307545081 0.430588120340667 no 1422 0.436496345916058 445 2737878
SGTC_615 k087-0205 167 µM 0.157668204873178 0.431477210541594 no 1423 0.437359127948919 482 9642773
SGTC_2858 9025781 8.96 µM 0.157642178611545 0.431487778213485 no 1424 0.437369382688307 474 4894980 YPL153C RAD53
SGTC_1504 k297-0033 30 µM 0.157076836392276 0.431717341175518 no 1425 0.437592146415869 439 4388117
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.1568713672941 0.431800779712045 no 1426 0.437673113012273 484 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2962 9082311 13.18 µM 0.156597620104581 0.431911949889197 no 1427 0.437780989142601 467 16459453
SGTC_579 4491-1009 110 µM 0.156521547658636 0.43194284426842 no 1428 0.437810967992728 502 1271041
SGTC_510 ag-490 170 µM 0.156516519135159 0.4319448864563 no 1429 0.437812949660423 478 5328779
SGTC_3271 9137798 49.47 µM 0.155903734252483 0.432193764729151 no 1430 0.438054450898224 473 6498326
SGTC_1140 3229-1848 2.98 µM 0.155898011237965 0.432196089218256 no 1431 0.438056706472495 479 2849525
SGTC_2124 5246320 200 µM 0.155782772645125 0.432242895619042 no 1432 0.438102125133312 476 579342
SGTC_2987 9018338 71.43 µM 0.151228703860107 0.43409337419595 no 1433 0.439897654138635 485 5055682
SGTC_2425 5628681 7.85 µM 0.15100767742199 0.434183222123316 no 1434 0.439984829822292 499 5714958
SGTC_2804 7954240 19.48 µM 0.150453977444934 0.434408317786155 no 1435 0.440203229014577 467 828705
SGTC_1818 st052136 56.3 µM 0.150403481168836 0.434428847097548 no 1436 0.440223147468968 483 674169
SGTC_141 0443-0274 32.331 µM 0.15036814294118 0.434443213994407 no 1437 0.44023708686161 465 1627241
SGTC_1195 1502-0147 41.1 µM 0.149425434365083 0.434826507814413 no 1438 0.440608971651873 491 817940
SGTC_2781 5567276 71.43 µM 0.14931443851075 0.434871641414177 no 1439 0.440652761351859 454 2853274
SGTC_837 0091-0265 12.5 µM 0.148923484247811 0.435030619631235 no 1440 0.440807005049954 480 759367
SGTC_2749 bexarotene 57.39 µM 0.148519391407857 0.435194951577268 no 1441 0.440966441766262 471 82146 An retinoic acid receptor inhibitor.
SGTC_3135 9127742 49.47 µM 0.148469738986675 0.435215144440038 no 1442 0.440986033021454 493 3643468
SGTC_1506 4226-2149 212 µM 0.147990111455488 0.435410210142667 no 1443 0.441175286113015 477 991114
SGTC_2822 7994718 71.43 µM 0.146979526525785 0.435821268924468 no 1444 0.44157409013361 504 1018011
SGTC_1045 1348-1485 165 µM 0.145421570473613 0.43645510843102 no 1445 0.442189017455981 455 6810614
SGTC_2373 9071805 200 µM 0.145340144816507 0.43648824018192 no 1446 0.44222116011505 476 10149009
SGTC_3176 9106582 49.47 µM 0.144166409211584 0.436965877559989 no 1447 0.442684532686875 481 17018027
SGTC_1304 1165-0502 251 µM 0.143958574048246 0.437050463139796 no 1448 0.442766590968462 469 767425
SGTC_192 3455-0609 60.9 µM 0.143817931533884 0.437107704021385 no 1449 0.442822121382043 460 3769639
SGTC_3021 9087658 49.47 µM 0.141925495646297 0.43787804463135 no 1450 0.443569427774511 496 25237042
SGTC_1927 st060202 13.8 µM 0.141219615621457 0.43816544272267 no 1451 0.443848225170497 495 688887
SGTC_1571 st070080 73.4 µM 0.141164129140947 0.438188035352323 no 1452 0.443870141528327 473 4315245
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.140614857975599 0.438411694923054 no 1453 0.444087104949932 465 115019
SGTC_525 k781-2675 26.7 µM 0.140446289070085 0.438480339010132 no 1454 0.444153693433659 487 3651118 YDL195W SEC31
SGTC_1547 harmine 94.2 µM 0.13959835129388 0.438825661530172 no 1455 0.444488671671596 481 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1401 3807-4679 7.6 µM 0.137803257250165 0.439556866622194 no 1456 0.445197955004621 484 3291456
SGTC_52 0329-0193 875 nM 0.136750664028137 0.439985721043125 no 1457 0.445613940783035 491 3739292
SGTC_1633 st005664 67.9 µM 0.136472894106139 0.440098903647704 no 1458 0.445723725708287 468 2063822
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.135803160663784 0.440371819309427 no 1459 0.445988446182025 496 97141
SGTC_102 gallobenzophenone 83.616 µM 0.134404754605018 0.440941759466768 no 1460 0.446541261059288 479 70837
SGTC_2865 9030313 51.95 µM 0.132271976095599 0.44181123870316 no 1461 0.447384586213077 500 42562754
SGTC_1773 st048542 73.5835 µM 0.131220122259047 0.442240156129783 no 1462 0.447800589164817 489 3237138
SGTC_1907 st060210 83.7 µM 0.131019228612386 0.442322082820211 no 1463 0.447880048145911 492 688793
SGTC_1829 berberine 14.4 µM 0.130776256025747 0.442421173071735 no 1464 0.447976153303134 481 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1038 k292-0204 154 µM 0.130637151601971 0.442477904930361 no 1465 0.448031175916127 492 4454212
SGTC_3335 9143315 29.6265 µM 0.130537460416482 0.44251856335828 no 1466 0.448070609278031 470 4899691
SGTC_823 0417-1665 178 µM 0.130323691927703 0.442605749542972 no 1467 0.448155168234317 494 3429856
SGTC_2658 polymyxin b sulfate 77.05 µM 0.130047128307875 0.442718551053176 no 1468 0.448264570131052 475 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3160 9100216 49.47 µM 0.127872281143213 0.443605763202733 no 1469 0.449125023688153 498 17191039
SGTC_1754 st042065 16.137 µM 0.126171244282737 0.444299885383508 no 1470 0.449798186584953 481 1126236 YIL048W NEO1
SGTC_1438 4092-1045 4 µM 0.124616594317912 0.444934422687151 no 1471 0.450413545221343 491 1351342
SGTC_821 1114-0266 29.2 µM 0.122846902853416 0.44565690180865 no 1472 0.451114166205512 489 3123235
SGTC_2253 7938677 135.83 µM 0.121200687771876 0.446329133618458 no 1473 0.451766039685612 476 2301972
SGTC_60 0986-0278 202 µM 0.118928429186981 0.447257263303627 no 1474 0.452666029182204 497 3110598
SGTC_2274 7947094 46.08 µM 0.118673251824153 0.447361511517848 no 1475 0.452767114358201 506 2971028
SGTC_967 1306-0166 352 µM 0.117722104393777 0.447750118020759 no 1476 0.45314392589546 509 4437607
SGTC_410 α-linolenic acid 100 µM 0.117521144002058 0.447832230035158 no 1477 0.453223544825123 509 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2292 7671323 168.05 µM 0.117391153197241 0.447885345209137 no 1478 0.453275047163317 499 937504
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.11604567683932 0.448435171205488 no 1479 0.453808170712545 477 688761
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.115686055043683 0.448582146693666 no 1480 0.453950679251952 502 6708514
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.115535340384702 0.448643745061627 no 1481 0.454010405221263 484 4000243
SGTC_2087 5276107 200 µM 0.115083360515919 0.448828480510915 no 1482 0.454189524326329 501 144405
SGTC_2078 5212016 200 µM 0.11470986116478 0.448981147388701 no 1483 0.454337548724516 511 1899708
SGTC_2965 9082772 38.63 µM 0.114464362891078 0.449081498278438 no 1484 0.454434847487593 476 16459634
SGTC_2313 7726885 200 µM 0.113437902171745 0.449501113815638 no 1485 0.45484169602096 487 726423
SGTC_2697 mebhydrolin 72.4 µM 0.11071596095694 0.450614111352106 no 1486 0.455920794391472 496 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3167 9103034 49.47 µM 0.110535771605892 0.450687804303261 no 1487 0.455992241016839 474 5127859
SGTC_1522 st012842 45.6 µM 0.10986764644047 0.450961065652658 no 1488 0.456257170786166 516 3491067 YOR116C RPO31
SGTC_2567 aureobasidin a 60 nM 0.106709650375637 0.452252989757243 no 1489 0.457509663216334 479 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1000 4048-0884 8.67 µM 0.106249005632414 0.452441480347747 no 1490 0.457692395044507 489 13040088
SGTC_349 k015-0014 24 µM 0.106246637739232 0.452442449290436 no 1491 0.457693334380329 478 2196908
SGTC_39 0986-0283 58.349 µM 0.105925103407346 0.452574023875585 no 1492 0.457820888237058 482 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_300 r073-0011 5.04 µM 0.105375920252179 0.452798766333082 no 1493 0.458038761262476 494 2735780
SGTC_1343 1487-0095 224 µM 0.105210308834783 0.452866542535158 no 1494 0.458104465428342 514 4560101 YGL055W OLE1
SGTC_156 3474-0145 5.642 µM 0.10514430761174 0.452893553810678 no 1495 0.458130650870312 494 2265471
SGTC_3226 9131256 49.47 µM 0.10460721078301 0.453113371018951 no 1496 0.458343746362407 479 17178073
SGTC_1371 2421-0008 32.7 µM 0.103291274572698 0.45365200381562 no 1497 0.45886590023065 496 2827552
SGTC_3151 9099821 49.47 µM 0.102074368282643 0.454150178059729 no 1498 0.459348822937722 492 17174189
SGTC_2220 6782180 200 µM 0.101997241353453 0.45418175454039 no 1499 0.459379432373175 502 833803
SGTC_1993 st073995 70.8 µM 0.101322235157809 0.454458120678031 no 1500 0.45964733295983 498 3098394
SGTC_992 3909-8734 162 µM 0.101033496948895 0.454576344798179 no 1501 0.459761934748161 489 4288319
SGTC_2366 9070441 60.58 µM 0.100988950623481 0.454594584689872 no 1502 0.459779615728439 475 6837235
SGTC_2470 5664817 21.68 µM 0.100367917704043 0.454848882132222 no 1503 0.460026119542994 500 2859561
SGTC_2689 tacrolimus 100 µM 0.0993760673251628 0.455255058381336 no 1504 0.460419842098315 516 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.0991848096765072 0.455333386388319 no 1505 0.460495767752525 501 442882
SGTC_1939 st074455 53.6 µM 0.0973338508080457 0.456091520733282 no 1506 0.461230637279037 523 1644229
SGTC_1386 3228-0095 33.8 µM 0.0972729127862512 0.456116483074705 no 1507 0.461254833217914 506 870181
SGTC_1290 0986-0249 10.2 µM 0.0969505052589663 0.456248555335096 no 1508 0.4613828501425 508 53329
SGTC_2350 9023895 38.85 µM 0.0967961045971917 0.456311806329173 no 1509 0.461444158745207 510 2997209
SGTC_759 3486-0358 89.3 µM 0.0957459988104004 0.456742016641094 no 1510 0.461861153461509 504 875103
SGTC_1941 st076221 61.8 µM 0.0956253253649073 0.456791457737743 no 1511 0.461909075317923 482 2828568
SGTC_983 1491-0821 12.2 µM 0.0948557338134012 0.45710678266325 no 1512 0.462214708607928 492 46495113
SGTC_2240 6690706 185.951 µM 0.0947350547899418 0.457156230962182 no 1513 0.4622626367431 495 805876
SGTC_1457 k015-0032 57.3 µM 0.0938567014160986 0.457516156695949 no 1514 0.462611494605152 500 4302660
SGTC_2707 st078556 66.6 µM 0.0938284311635973 0.457527741670151 no 1515 0.462622723253005 511 17250899
SGTC_918 glabranin 770.725 nM 0.0935466739967224 0.457643205980894 no 1516 0.462734635871453 500 124049 Also referred to as licorice root.
SGTC_70 0141-0289 43.283 µM 0.0933862583450903 0.457708946040099 no 1517 0.462798353530421 487 352408
SGTC_1053 3366-3204 134 µM 0.0919872459735853 0.458282325209046 no 1518 0.463354086432379 489 3632071 YPR165W RHO1
SGTC_1884 5633444 25 µM 0.0917471264306075 0.458380745927586 no 1519 0.463449476892005 499 5724239
SGTC_1540 guanosine 70.6 µM 0.091500953146742 0.458481650615457 no 1520 0.463547274456701 504 6802 Guanosine is a purine nucleoside
SGTC_772 k072-0172 35.3 µM 0.0914165047273623 0.45851626604191 no 1521 0.463580823892394 487 5861980
SGTC_1253 0550-0034 176 µM 0.09049644990897 0.458893417051315 no 1522 0.463946357470857 497 5969915
SGTC_3108 9121785 49.47 µM 0.0892394535458243 0.459408747668073 no 1523 0.464445805522729 514 17140271
SGTC_1762 st045503 25.4615 µM 0.0889228421515496 0.459538559583392 no 1524 0.464571615024665 496 4645554
SGTC_1657 st012939 43.4 µM 0.0886159509273852 0.459664390308028 no 1525 0.464693565476061 516 24207257
SGTC_2416 tofa 880 nM 0.0883287214470044 0.459782163037353 no 1526 0.464807705875622 446 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2652 actinonin 100 µM 0.0879798763066174 0.459925204785989 no 1527 0.464946335245954 510 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2688 kanamycin b 96.69 µM 0.0864882507523716 0.460536894714184 no 1528 0.465539147807611 505 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2918 7977171 22.06 µM 0.0854489384989063 0.460963154050615 no 1529 0.465952244051196 509 2236483
SGTC_77 0828-0286 12.516 µM 0.0854456015101445 0.460964522742233 no 1530 0.465953570466019 459 745345
SGTC_217 ketoconazole 989 nM 0.0854259064335856 0.46097260083885 no 1531 0.465961399041139 500 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_845 0330-0138 4.51 µM 0.0853862804827542 0.460988853795237 no 1532 0.465977149958268 522 9039800
SGTC_2526 patulin 37.61 µM 0.0849863723974253 0.461152883500032 no 1533 0.466136112380973 496 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_742 0kpi-0133 140 µM 0.0849673004839945 0.461160706363745 no 1534 0.466143693552079 517 2728852
SGTC_2464 5717415 7.67 µM 0.083565733949574 0.46173563791212 no 1535 0.466700855977928 502 5285744
SGTC_644 1498-1197 63.3 µM 0.0832179641689118 0.461878307728311 no 1536 0.466839114471187 499 6741615
SGTC_31 0508-1974 57.237 µM 0.0831419937182099 0.461909474661442 no 1537 0.466869317628637 508 6810525
SGTC_2460 5552655 174.22 µM 0.0830547784023001 0.46194525509716 no 1538 0.466903991580985 460 5401989
SGTC_1501 4491-0275 38.4 µM 0.082300443053267 0.462254737042663 no 1539 0.467203901055862 512 5104718
SGTC_3053 9095903 49.47 µM 0.0821463574064376 0.462317956737601 no 1540 0.467265164891881 517 17174018
SGTC_785 1270-0111 65.3 µM 0.0805569957959655 0.462970110092181 no 1541 0.467897133692197 521 6741994
SGTC_274 sirtinol 40.1 µM 0.080466900646156 0.463007081300068 no 1542 0.467932960151659 508 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2427 5545055 42.75 µM 0.0799469105395284 0.463220469302166 no 1543 0.468139739994768 497 5372858
SGTC_810 3825-7150 143 µM 0.079930066272971 0.463227381850179 no 1544 0.468146438448551 494 22330411 YGL099W LSG1
SGTC_2367 9070478 135.38 µM 0.0791453021834788 0.463549445513392 no 1545 0.468458525284479 516 572802
SGTC_100 0086-0128 49.5915 µM 0.0788896634171786 0.463654363685643 no 1546 0.46856019250764 515 93297
SGTC_276 colchicine 750 µM 0.0780426311399566 0.464002017084649 no 1547 0.468897070818771 513 2833 A microtubule depolymerizer.
SGTC_2864 9034755 47.6 µM 0.0777736094793116 0.464112439296068 no 1548 0.469004069715707 514 4930451
SGTC_463 ikarugamyin 104 µM 0.0776943845340533 0.464144958370881 no 1549 0.469035580548787 523 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1637 st007924 17.4 µM 0.0776757488476392 0.464152607704512 no 1550 0.469042992712153 516 683336
SGTC_3247 9135149 49.47 µM 0.0776483975449381 0.464163834534697 no 1551 0.469053871446719 518 8934436 YOR116C RPO31
SGTC_2233 sulbentine 40.3845 µM 0.0772312988347444 0.464335043672148 no 1552 0.469219771563883 501 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2009 4012297 12.05 µM 0.0769932782251846 0.464432748454179 no 1553 0.469314446147584 496 45595307
SGTC_87 0100-0052 35.5 µM 0.0748129247885482 0.465327858073774 no 1554 0.47018177907204 514 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3023 9089636 49.47 µM 0.0731597856015141 0.466006645416463 no 1555 0.470839483517991 525 17249241
SGTC_566 0958-0068 16.5 µM 0.0727852290610148 0.466160454046964 no 1556 0.47098851263978 506 6815365
SGTC_2415 st077333 57.7 µM 0.0702068130403263 0.467219395784849 no 1557 0.472014525843317 528 2766255
SGTC_435 c-PAF 6.7 µM 0.0701793380339479 0.467230680886555 no 1558 0.472025459815598 524 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1901 st060216 58.6 µM 0.0698650902359619 0.467359757099521 no 1559 0.472150519581181 494 688792
SGTC_3154 9100113 49.47 µM 0.0697394009798843 0.467411384495156 no 1560 0.472200540331645 502 25237525
SGTC_1791 st048313 56.1 µM 0.0687295085207131 0.467826221935587 no 1561 0.472602464665933 521 1204976
SGTC_715 0868-0130 184 µM 0.0683511612339458 0.467981646139162 no 1562 0.472753049272182 500 2876258
SGTC_2556 citropten 84.59 µM 0.0663685703351564 0.468796169219477 no 1563 0.473542196126795 513 2775 A potential DNA crosslinker.
SGTC_2486 5283202 22.39 µM 0.0662480065582952 0.468845705611663 no 1564 0.473590188492628 507 1377751
SGTC_210 3551-0445 56.827 µM 0.0661703363183041 0.468877618466189 no 1565 0.473621106593826 511 2865180 YOR207C RET1
SGTC_139 0099-0334 718.624 µM 0.0655075200456141 0.469149962023608 no 1566 0.473884959533967 517 97690
SGTC_1358 1509-0022 2.48 µM 0.0653091650313846 0.469231466622026 no 1567 0.473963922642743 494 3258434
SGTC_1656 st012921 11 µM 0.0652965742920097 0.469236640233593 no 1568 0.473968934922274 522 6732821
SGTC_1226 3909-7979 35.4 µM 0.0647242425644717 0.469471820300528 no 1569 0.474196780257189 525 6615510
SGTC_2842 9000675 19.48 µM 0.0647188683431004 0.469474028702831 no 1570 0.474198919775529 531 2989072
SGTC_855 0428-0020 25 µM 0.0638061595821612 0.469849097183141 no 1571 0.474562286809129 527 6812414
SGTC_2891 9063876 19.48 µM 0.0620237874594434 0.470581621903888 no 1572 0.475271944407082 528 6472478
SGTC_965 1291-5240 308 µM 0.0616195038009047 0.470747789573358 no 1573 0.475432922334493 515 2834598
SGTC_2696 st077691 74.316 µM 0.0606388483468309 0.471150877257463 no 1574 0.475823416964489 522 757133
SGTC_1423 4048-0112 5.59 µM 0.0600280461929921 0.471401955757356 no 1575 0.47606664866485 527 X1423
SGTC_3013 9080133 71.4286 µM 0.0599347524619641 0.471440306412508 no 1576 0.47610380058649 514 17050193
SGTC_749 1000-0129 128 µM 0.0598096242510225 0.471491743819935 no 1577 0.476153630128732 517 708470
SGTC_1616 st002734 56.1 µM 0.0594503690391868 0.47163942823791 no 1578 0.476296697639995 516 4026101
SGTC_1840 st055363 71 µM 0.05933687526751 0.471686084633195 no 1579 0.476341895313998 495 676033
SGTC_1739 st037196 92.5 µM 0.0590546542690661 0.471802105145054 no 1580 0.476454288109747 510 612214
SGTC_1964 st076914 61 µM 0.0580080007388276 0.472232403222142 no 1581 0.476871127796059 525 24208661
SGTC_3078 9116413 49.47 µM 0.0573421777408013 0.47250615192179 no 1582 0.47713631131402 528 17177322
SGTC_500 h-89 112 µM 0.0563095449843836 0.472930737658786 no 1583 0.477547607551558 508 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3070 9117005 49.47 µM 0.05472375799512 0.47358282253561 no 1584 0.478179270788583 525 8779016
SGTC_2716 st080858 38.6235 µM 0.0531686432973049 0.474222363550627 no 1585 0.478798769643449 528 5296050
SGTC_858 0438-0351 2.77 µM 0.0530549719414972 0.474269113528232 no 1586 0.478844054037702 527 2799119
SGTC_2361 9034121 116 µM 0.0526216233872931 0.47444734140184 no 1587 0.479016693933062 527 6496917
SGTC_1198 1612-1005 86.7 µM 0.0522392215992326 0.474604620105259 no 1588 0.479169040632853 533 6998509
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0521562225538924 0.474638757452063 no 1589 0.479202107383694 523 688801
SGTC_1380 2291-0730 164 µM 0.0515762354133767 0.474877310223899 no 1590 0.479433177761912 511 2999191
SGTC_2979 9012552 45.46 µM 0.051388040664421 0.474954717981437 no 1591 0.479508157175129 528 17100905
SGTC_1361 1608-0041 5.61 µM 0.0498320441039265 0.475594762250232 no 1592 0.480128115446935 533 X1361
SGTC_3024 9090631 49.47 µM 0.0494679510210187 0.475744537603086 no 1593 0.480273188649075 534 25236383
SGTC_471 1-acyl-paf 4 µM 0.049072845605206 0.475907074238394 no 1594 0.480430621697575 520 16759367
SGTC_3261 9137475 49.47 µM 0.0466583481608972 0.476900425118563 no 1595 0.481392763759804 537 17027690
SGTC_1607 st000305 50.6 µM 0.0443569006031787 0.477847399749897 no 1596 0.482309958073643 533 5457690
SGTC_628 1636-0253 16 µM 0.0436715708658463 0.478129416195607 no 1597 0.482583100375499 522 4456143
SGTC_3232 9132874 49.47 µM 0.043614249214954 0.478153004825778 no 1598 0.482605946637576 534 3784940
SGTC_828 2074-0507 139 µM 0.0423974193453915 0.478653764605523 no 1599 0.483090942782649 533 X828
SGTC_2130 NSC 7 2.4545 µM 0.0421341841319847 0.478762097774102 no 1600 0.483195864680665 535 21448
SGTC_458 nppb 133 µM 0.0407202995882995 0.479344001712363 no 1601 0.483759439142433 525 4549 A chloride channel blocker.
SGTC_2076 5212012 200 µM 0.040270955754719 0.479528944723994 no 1602 0.483938554469112 534 604802
SGTC_360 0957-0399 1.01 µM 0.0399248225444525 0.479671410837433 no 1603 0.484076530674172 518 6752301 YPR165W RHO1
SGTC_1902 st060212 70.5 µM 0.0392947748021596 0.479930740925775 no 1604 0.484327686252261 520 688944
SGTC_2523 spermine 47.74 µM 0.0373765000987018 0.480720362061644 no 1605 0.485092404889904 519 1103 A DNA binding polyamine.
SGTC_3098 9119039 49.47 µM 0.0369694058470154 0.480887944469197 no 1606 0.485254699827265 534 17161528
SGTC_879 0831-1030 162 µM 0.0364911405121105 0.481084829125954 no 1607 0.48544537142664 536 1549252
SGTC_2792 7535235 81.82 µM 0.0360988168613229 0.481246338125759 no 1608 0.485601782861218 526 1281891
SGTC_1337 1486-1011 40.3 µM 0.034730518615164 0.481809653297775 no 1609 0.486147312632629 532 X1337
SGTC_3255 9139072 49.47 µM 0.0345683904284907 0.481876402334922 no 1610 0.486211953605936 536 17646060
SGTC_2627 acetyl isogambogic acid 100 µM 0.0343196269858036 0.481978820555146 no 1611 0.486311137008248 524 6857789 A caspase activator and apoptosis inducer.
SGTC_158 k038-0087 26.446 µM 0.0342800701638188 0.481995106575991 no 1612 0.486326908616798 520 X158
SGTC_1775 st081588 35.1725 µM 0.0341713719014868 0.482039859116624 no 1613 0.486370247558374 536 1426443 YGL099W LSG1
SGTC_809 3998-0021 90 µM 0.033637672578789 0.482259593598739 no 1614 0.486583040441063 541 715485
SGTC_2394 5221648 200 µM 0.0334788770527149 0.482324973875631 no 1615 0.486646355029138 528 788586
SGTC_567 1080-0542 68.4 µM 0.0334260496525379 0.482346724405276 no 1616 0.48666741832371 533 5950415
SGTC_2972 9093619 59.92 µM 0.0318515221093626 0.482995025610486 no 1617 0.487295229377921 521 25236256
SGTC_693 4161-2696 114 µM 0.0311707313734601 0.483275350675502 no 1618 0.48756669077393 535 805759
SGTC_1187 1391-0724 117 µM 0.0295996724360122 0.483922287392756 no 1619 0.488193163279263 519 6997986
SGTC_2003 4023581 200 µM 0.0287622847200242 0.484267127542144 no 1620 0.488527090429825 530 16641307
SGTC_1143 3454-2408 5.08 µM 0.0284945467650502 0.484377385770139 no 1621 0.488633858657964 538 X1143
SGTC_788 1182-0090 188 µM 0.0273262612486832 0.484858515925439 no 1622 0.489099755619505 532 5715185
SGTC_2778 tioconazole 65.09 nM 0.0256854537716986 0.485534279893773 no 1623 0.489754113119457 536 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2380 9035439 200 µM 0.0248543426311118 0.485876587677616 no 1624 0.490085572637036 532 6462575
SGTC_1179 1021-1431 9.29 µM 0.0246659810721307 0.485954169163966 no 1625 0.490160694995808 535 2840958
SGTC_2762 leflunomide 42.06 µM 0.0245956896065397 0.485983120623564 no 1626 0.490188728728363 538 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2757 clomiphene 4.22 µM 0.0245023532645425 0.486021563858969 no 1627 0.490225953322996 538 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1780 st038448 24.544 µM 0.0244340526045654 0.486049695516782 no 1628 0.490253193188656 519 728868 YDL195W SEC31
SGTC_2029 5175081 200 µM 0.0239546963784194 0.486247134578273 no 1629 0.490444372689463 538 1380876
SGTC_944 3370-0224 231 µM 0.0238779251297748 0.486278755725951 no 1630 0.490474991228458 537 4580514
SGTC_1946 st076057 65.1 µM 0.0236490940128963 0.486373009003073 no 1631 0.490566255863446 538 953009
SGTC_2897 9048598 12.99 µM 0.0231888420778561 0.486562584529597 no 1632 0.490749819473894 542 6467404
SGTC_1105 epirubicin 18.1 µM 0.0227339262173929 0.48674996513725 no 1633 0.490931256807625 538 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2102 5377816 72.7585 µM 0.0224162479816874 0.486880819073709 no 1634 0.491057959796654 538 1379702
SGTC_259 usnic acid 108.925 µM 0.0193348817707103 0.488150127021763 no 1635 0.492286978747722 532 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2496 diffractaic acid 79.83 µM 0.0191732208834196 0.488216723457332 no 1636 0.492351460157346 540 94870 An apoptosis inducer which activates caspases.
SGTC_3107 9121808 49.47 µM 0.0181173373057081 0.488651704216142 no 1637 0.492772623525781 533 662681
SGTC_2408 sulbentine 18.36 µM 0.0178550976616162 0.488759738314369 no 1638 0.492877225086226 520 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_456 gingerol 170 µM 0.0177479015812318 0.488803899807605 no 1639 0.49291998335952 539 442793 A herb.
SGTC_3062 9077494 49.47 µM 0.0174593600005322 0.48892277075853 no 1640 0.493035076960882 535 16459633
SGTC_1385 3091-4834 14.1 µM 0.0174398128235736 0.48893082367697 no 1641 0.493042873969095 534 4072814
SGTC_2211 7117706 200 µM 0.0148404507177578 0.490001730832254 no 1642 0.49407973406149 544 822771
SGTC_994 3910-0338 138 µM 0.0143980128704049 0.490184017504741 no 1643 0.494256222363091 538 3479481
SGTC_1985 st071382 65.5 µM 0.0136437839156744 0.490494768425726 no 1644 0.494557086600864 532 6123237
SGTC_350 k064-0020 19.8 µM 0.0136258204850196 0.490502169634872 no 1645 0.494564252306742 539 2790705
SGTC_2182 6325192 200 µM 0.0122514111550131 0.491068456881231 no 1646 0.495112516362156 545 736248
SGTC_1167 k781-0610 148 µM 0.0115972732841045 0.491337982642111 no 1647 0.495373461058907 540 4525169
SGTC_1764 st044502 93.5 µM 0.0106871739739766 0.491712979269139 no 1648 0.495736515603396 538 8407
SGTC_197 4544-0043 41.561 µM 0.0103895435447677 0.49183561629008 no 1649 0.495855246371979 541 896523
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.008986790324619 0.492413623422562 no 1650 0.496414837632192 541 5106787 A p450 inhibitor.
SGTC_940 3232-1287 54.8 µM 0.00792414636510875 0.492851498556813 no 1651 0.496838756062425 544 1585493 YIL048W NEO1
SGTC_2349 9023730 187.07 µM 0.00716356854788734 0.493164909049382 no 1652 0.497142174070088 544 4126287
SGTC_509 pifithrin 175 µM 0.00708903852634021 0.493195620786243 no 1653 0.497171906491857 545 4817 A p53 inhibitor.
SGTC_916 4466-0038 42 nM 0.00558851589874476 0.49381395251655 no 1654 0.497770516328325 544 5722064 YGL116W CDC20
SGTC_105 0111-0055 734.78 µM 0.0052092124157761 0.493970257389225 no 1655 0.497921834318573 537 5179370
SGTC_1059 3448-6867 171 µM 0.00394161888509326 0.494492618902672 no 1656 0.498427525645263 546 3934407
SGTC_2255 7941087 197.44 µM 0.00389217224164563 0.494512995524066 no 1657 0.498447251850635 545 935561
SGTC_2874 9043904 71.43 µM 0.00198041920405246 0.49530082625643 no 1658 0.499209927563037 543 4463428
SGTC_176 1486-1328 72.834 µM 0.00186658458400107 0.49534773795146 no 1659 0.499255340921912 547 22310231
SGTC_308 4092-1169 104 µM 0.00173450104124764 0.495402170179961 no 1660 0.499308034546208 547 2268590 YDL196W YDL196W
SGTC_2944 9067346 25.62 µM 0.00163505520326039 0.495443152318478 no 1661 0.499347707639269 544 6473075
SGTC_2444 5485484 36.41 µM 0.00140321420559674 0.49553869536553 no 1662 0.499440198708637 546 6790631
SGTC_2755 lomerizine 42.69 µM 0.00133058930122831 0.495568624571271 no 1663 0.499469171826526 547 3949 A calcium channel blocker.
SGTC_607 4491-0986 66.8 µM 0.000638151294024263 0.495853984104413 no 1664 0.4997454144848 547 698981 YDR232W HEM1
SGTC_3306 9127676 59.7925 µM -0.000499284823103272 0.496322735642224 no 1665 0.499800814182377 550 41905287
SGTC_1716 st033144 30.6155 µM -0.00112301456789146 0.496579784606421 no 1666 0.499551982101532 550 674617
SGTC_1928 4'-methoxychalcone 40.3 µM -0.00134744812151356 0.496672277602197 no 1667 0.499462446136346 549 641818
SGTC_2793 7325131 81.82 µM -0.00142323603592503 0.496703511168915 no 1668 0.499432211161964 549 4176441
SGTC_1697 st025554 27.742 µM -0.0016629671781607 0.496802308829441 no 1669 0.499336572387492 550 1269519
SGTC_2198 6589944 200 µM -0.00242556352595347 0.497116590236632 no 1670 0.499032341104545 549 5290268
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.00332651557633627 0.497487893123119 no 1671 0.498672914737709 551 77254
SGTC_529 4076-0302 30.3 µM -0.00339148048686966 0.497514666732258 no 1672 0.498646997634369 555 5816522
SGTC_2572 astragaloside iv 100 µM -0.00606541785957324 0.498616669235915 no 1673 0.497580263204258 549 45006101 An anti-inflammatory agent.
SGTC_1328 1441-0025 69.2 µM -0.00654432597783885 0.498814041687729 no 1674 0.497389210306629 551 4562601
SGTC_1881 5652484 16 µM -0.00786572262700414 0.499358630382585 no 1675 0.496862063035358 555 2255129
SGTC_2095 5432005 200 µM -0.00790243283275554 0.49937375982294 no 1676 0.49684741823732 550 783734
SGTC_1963 st076565 50.3 µM -0.00859395416672419 0.499658757846045 no 1677 0.496571550529069 552 4914280
SGTC_2282 7944268 200 µM -0.00940033511493672 0.499991093393602 no 1678 0.49624986410373 554 2970414
SGTC_3350 9150499 3.57 µM -0.00944355719495241 0.499991093393602 no 1679 0.496232621753911 554 4910996 YPR165W RHO1
SGTC_1479 0549-0158 134 µM -0.0101033700601481 0.499719163260482 no 1680 0.495969407081117 556 5440202
SGTC_1255 0566-0045 221 µM -0.0101916814865547 0.499682767284443 no 1681 0.495934177733162 556 2788469
SGTC_430 0958-0115 16.4 µM -0.0110720553933492 0.499319937107196 no 1682 0.495582979220229 560 6833180
SGTC_613 3914-0030 117 µM -0.0113260788921659 0.499215246009497 no 1683 0.49548164486144 550 1145395
SGTC_3331 9141060 1.957 µM -0.0114681581915245 0.499156690671073 no 1684 0.495424967102982 557 4906567 YPR165W RHO1
SGTC_559 1550-0661 158 µM -0.0121662802171859 0.498868972961599 no 1685 0.495146476161566 560 5830875
SGTC_1001 4048-4355 44.4 µM -0.0126942512617201 0.498651380124089 no 1686 0.494935862463268 557 21824233
SGTC_1781 st038725 66.3 µM -0.0127839512616747 0.498614412078955 no 1687 0.494900080244318 556 4270275 YIL048W NEO1
SGTC_3288 9119690 36.221 µM -0.0128878928903795 0.498571574648783 no 1688 0.494858616949858 558 17595618 YKL019W RAM2
SGTC_160 3453-0671 289.699 µM -0.0138381484400911 0.498179946958909 no 1689 0.494479553694387 561 5322268
SGTC_309 k408-0051 1.48 µM -0.014674306660807 0.497835343503772 no 1690 0.494146008733319 555 3640463
SGTC_1121 fusaric acid 630.51 nM -0.0155451498311083 0.497476447162083 no 1691 0.493798632240028 559 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0156856263496161 0.497418553444439 no 1692 0.493742597049674 555 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2136 5328288 199.296 µM -0.016281359495339 0.497173038251055 no 1693 0.493504964269727 558 262395
SGTC_171 k064-0041 9.68 µM -0.017915394709998 0.496499620907766 no 1694 0.492853173891327 551 53325
SGTC_1118 chelidonine 707.474 nM -0.0187409669537183 0.496159390378278 no 1695 0.492523873541427 555 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_491 tetrandrine 80.3 µM -0.019008181039493 0.496049268088665 no 1696 0.492417289531953 566 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2197 6588183 93.1375 µM -0.0191140460252166 0.496005639877748 no 1697 0.492375063184817 558 884136
SGTC_2067 5224629 34.075 µM -0.0191767306176026 0.495979806839386 no 1698 0.492350060233373 558 2835000
SGTC_1659 st012954 42.1 µM -0.0192826716884926 0.495936147349253 no 1699 0.492307803674551 566 24207262
SGTC_2561 acetosyringone 100 µM -0.0193321917875329 0.495915739583954 no 1700 0.4922880516952 552 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_938 3126-1755 342 µM -0.0198879312934427 0.495686714103291 no 1701 0.49206638633756 550 1777771
SGTC_743 1275-0778 158 µM -0.0213720336177122 0.495075108741451 no 1702 0.491474441204476 565 2849257 YMR203W TOM40
SGTC_2698 st077697 67.5 µM -0.0217969416138807 0.494900004279669 no 1703 0.491304966923592 560 3154499
SGTC_3099 9120367 49.47 µM -0.0222772810487243 0.494702057723151 no 1704 0.491113385740773 552 24824940
SGTC_1837 st055472 66.5 µM -0.0236361131783054 0.494142093975238 no 1705 0.490571433020052 567 676091
SGTC_2338 7999974 200 µM -0.0242139638379682 0.493903969818442 no 1706 0.490340969932196 562 315925
SGTC_1356 1502-0781 85.8 µM -0.0259291823161603 0.493197165447563 no 1707 0.489656911872635 567 567702
SGTC_3297 9117502 71.43 µM -0.0260870822654437 0.493132099339502 no 1708 0.489593940208199 562 7453720
SGTC_1079 idarubicin 2.36 µM -0.0270295609601977 0.492743734356517 no 1709 0.489218078201857 559 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_49 0717-0965 32.132 µM -0.0275555890575718 0.492526978160578 no 1710 0.489008301499827 572 5889349 YGL099W LSG1
SGTC_582 0987-0078 156 µM -0.0292176763104479 0.491842109947304 no 1711 0.488345491797337 561 1625765
SGTC_1887 st057648 70.8 µM -0.0303188679551855 0.491388373630151 no 1712 0.487906374518606 563 688672
SGTC_2448 5185112 27.17 µM -0.0307109771552978 0.491226811148064 no 1713 0.48775001839442 562 5718189
SGTC_2879 9041815 71.43 µM -0.0308782138951605 0.491157904293288 no 1714 0.487683332215117 561 4942971
SGTC_1631 benzylvanillin 81.9 µM -0.0310793275917415 0.491075039404747 no 1715 0.487603137948339 572 75506
SGTC_18 0111-0177 500 nM -0.0320323561060137 0.490682368306544 no 1716 0.487223123844592 560 721752
SGTC_1660 st012960 28.1 µM -0.0324691865438271 0.490502386458445 no 1717 0.487048944321652 561 24207266
SGTC_1011 4112-3381 17.4 µM -0.0337037558153472 0.489993732711256 no 1718 0.486556691984059 595 2877139
SGTC_1032 k061-1018 98.7 µM -0.0352297566675444 0.489365029085487 no 1719 0.485948267281818 587 4005393
SGTC_2010 4012422 159 µM -0.0355902060912834 0.489216529783697 no 1720 0.485804558891356 575 952393
SGTC_2788 5282734 71.43 µM -0.0364877596372082 0.488846758856689 no 1721 0.485446719302949 565 743706
SGTC_2370 9071495 200 µM -0.0365529893913607 0.488819886103726 no 1722 0.485420713744164 583 21791103
SGTC_1683 st010134 710 nM -0.0371767248811282 0.488562927885559 no 1723 0.485172048317315 592 3818134
SGTC_627 1391-0720 175 µM -0.0377241418981184 0.488337414240689 no 1724 0.484953813621519 570 997839
SGTC_347 4534-1311 26.2 µM -0.0381228586626435 0.488173161421515 no 1725 0.484794862989157 563 2862016
SGTC_2616 abietic acid 100 µM -0.038706396187912 0.487932774642728 no 1726 0.484562236906011 566 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3181 9108277 49.47 µM -0.0398823276235962 0.487448366128547 no 1727 0.484093470203066 568 17097298
SGTC_1224 0823-0416 294 µM -0.0402188075515502 0.487309761302586 no 1728 0.483959341751316 569 3598164
SGTC_2414 st077232 92.9 µM -0.0413398484764759 0.486847986569202 no 1729 0.483512482858995 562 729801
SGTC_904 1141-0088 396 µM -0.0419538343631931 0.486595083370856 no 1730 0.483267750264486 595 1378119
SGTC_990 3985-0011 41.3 µM -0.0424636858158517 0.486385077647596 no 1731 0.483064530072604 580 5399565 YGL099W LSG1
SGTC_390 dec-rvkr-cmk 16.7 µM -0.0431482472465382 0.486103115548995 no 1732 0.482791679673061 575 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1724 st037281 8.293 µM -0.043293319885055 0.486043362871887 no 1733 0.482733858095505 572 574124 YDL195W SEC31
SGTC_2471 5466956 24.79 µM -0.0433437858526658 0.486022576967315 no 1734 0.482713743968212 567 724419
SGTC_1129 3453-1384 223 µM -0.0438021036669139 0.48583380693642 no 1735 0.482531075105868 606 1084452
SGTC_2344 7990960 76.95 µM -0.0438101555580907 0.485830490585296 no 1736 0.48252786594667 577 140813
SGTC_3120 9124077 49.47 µM -0.0441422645355171 0.485693704945729 no 1737 0.482395501686469 580 18774327 YGL155W CDC43
SGTC_3009 9080819 71.4286 µM -0.044503473240748 0.485544935920223 no 1738 0.482251541738019 571 17027216
SGTC_1737 st035557 69.7 µM -0.0482981381513366 0.483982173883983 no 1739 0.480739319181987 570 5716916
SGTC_359 0081-0058 15.9 µM -0.048927564398219 0.483722979556091 no 1740 0.480488510975148 566 3494159
SGTC_2857 9024691 58.44 µM -0.052712962382912 0.48216432204477 no 1741 0.478980305448871 588 16478292
SGTC_2978 9011784 42.97 µM -0.0528724183697344 0.482098671020252 no 1742 0.478916780300101 571 2994934
SGTC_1950 st077106 7.18 µM -0.0529826932640109 0.482053269059037 no 1743 0.478872848559011 565 13831864
SGTC_3237 9133362 49.47 µM -0.0530801853072829 0.482013130198582 no 1744 0.478834009513554 580 43845137
SGTC_1264 0783-0040 158 µM -0.0537846608837736 0.481723093030713 no 1745 0.47855336533537 571 2855798
SGTC_1175 0741-0056 27.6 µM -0.0545527616074892 0.481406872005427 no 1746 0.478247386726802 578 765927
SGTC_505 gw-5074 63.9 µM -0.0548202466934693 0.481296753235998 no 1747 0.47814083506356 565 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2368 9071271 200 µM -0.0550644862008423 0.48119620549686 no 1748 0.478043544552304 587 27209959
SGTC_3250 9135583 49.47 µM -0.0551958139968357 0.481142141384009 no 1749 0.47799123190016 567 7699353
SGTC_1199 1638-0010 4.46 µM -0.0559340657487641 0.480838229525523 no 1750 0.47769716637812 571 3111136
SGTC_1955 wogonin 32.4 µM -0.0574835053367181 0.480200417055431 no 1751 0.477080022607543 574 5281703 A flavanone.
SGTC_2840 9008771 71.43 µM -0.0589654520313916 0.479590434811971 no 1752 0.476489812748268 563 2992978
SGTC_856 0433-0016 11.3 µM -0.0597116940659693 0.479283293056024 no 1753 0.476192628918949 583 3911780
SGTC_2482 5981709 142.65 µM -0.0606043402749521 0.478915909764705 no 1754 0.475837158420392 584 877755
SGTC_688 0527-0193 473 µM -0.0607243396679194 0.478866523391493 no 1755 0.475789373597838 571 4007154
SGTC_335 4077-0256 27.6 µM -0.0621832888202919 0.478266111471588 no 1756 0.47520843516149 585 3121989
SGTC_903 1134-0042 114 µM -0.0632364963472986 0.477832707919713 no 1757 0.474789091520295 578 701009
SGTC_2908 7930301 100 µM -0.0633823318379088 0.477772697471643 no 1758 0.474731028055395 578 2223178
SGTC_3265 9137266 49.47 µM -0.0638372095198894 0.477585521220206 no 1759 0.474549924878175 598 17224265
SGTC_840 0245-0196 390 µM -0.0649357043599284 0.477133525344876 no 1760 0.474112596301907 573 3827528
SGTC_1236 0330-0013 258 µM -0.0655161967168158 0.476894682946583 no 1761 0.473881505463028 600 4617066
SGTC_3124 9127567 49.47 µM -0.0661173798339872 0.476647336127078 no 1762 0.473642187010449 605 17592030
SGTC_805 3852-0218 479 µM -0.0664079958202952 0.476527770221056 no 1763 0.473526502256598 576 6615355
SGTC_1520 flindersine 88 µM -0.0667730031229835 0.476377601061526 no 1764 0.473381207908058 592 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3011 9081274 71.4286 µM -0.0673023547749177 0.476159824281931 no 1765 0.473170501151089 574 6625322
SGTC_2759 disulfiram 3.38 µM -0.067535404680442 0.476063949139782 no 1766 0.473077738747005 579 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_48 0382-0018 55 µM -0.0680414006433904 0.475855790628644 no 1767 0.472876338841056 571 762596
SGTC_2677 mitomycin C 100 µM -0.0688626035867393 0.475517975141043 no 1768 0.472549492920179 573 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1317 1273-0028 910 nM -0.0708974046700861 0.474681002213813 no 1769 0.471739704476435 587 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_573 3702-0553 84.7 µM -0.071033626800336 0.474624974034953 no 1770 0.47168549638001 591 1222756
SGTC_43 0570-0105 72.5 µM -0.07109024662305 0.474601686442514 no 1771 0.471662965299416 574 1114046 YDL195W SEC31
SGTC_1814 st052110 31.539 µM -0.07190963375589 0.474264684304888 no 1772 0.471336911635819 602 674163
SGTC_3275 9138069 49.47 µM -0.0720050910925666 0.47422542526882 no 1773 0.471298928132332 569 17617007
SGTC_522 1273-0010 11.6 µM -0.0721501839139546 0.474165752971898 no 1774 0.47124119463442 569 5705015
SGTC_191 3914-0123 66.505 µM -0.072354212004347 0.474081843359026 no 1775 0.471160011383423 599 3144412
SGTC_2854 9024559 71.43 µM -0.0729636800275947 0.473831197353598 no 1776 0.470917509791783 595 3163529
SGTC_229 benomyl 22.8748 µM -0.0734496306265766 0.473631355768947 no 1777 0.470724162343539 588 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2439 5492030 7.2 µM -0.0735189173654651 0.473602862935255 no 1778 0.470696595464227 583 5722370
SGTC_2598 perillyl alcohol 100 µM -0.0735719349901643 0.473581060551871 no 1779 0.470675501616911 583 10819 An apoptosis inducer.
SGTC_1390 3413-2614 145 µM -0.073926303877682 0.473435335833363 no 1780 0.470534512821649 614 3421432
SGTC_914 3820-6779 408 µM -0.0741074832757596 0.473360832028251 no 1781 0.470462430421931 587 2893481
SGTC_3268 9137683 49.47 µM -0.0741561077838547 0.47334083702773 no 1782 0.470443085278728 581 1953228
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0744425032300518 0.473223069034392 no 1783 0.47032914495847 577 279621
SGTC_1505 k297-0037 20.6 µM -0.0750492223652498 0.47297358923878 no 1784 0.470087774251758 583 4089396
SGTC_3051 9093778 49.47 µM -0.0755610505766659 0.472763136343976 no 1785 0.46988416248667 586 17217378
SGTC_1197 1601-0112 267 µM -0.07605588810434 0.472559676885577 no 1786 0.469687317317503 587 7350313
SGTC_2911 7942208 15.64 µM -0.076770076436652 0.47226604087409 no 1787 0.46940322800424 578 1243384
SGTC_1527 coumarin 137 µM -0.0780493033363829 0.471740129032515 no 1788 0.468894417091988 614 323 A hepatotoxic, DNA x-linker.
SGTC_2294 7971431 200 µM -0.0781662995788905 0.471692032341322 no 1789 0.468847884504615 606 5741572
SGTC_563 tetrahydrosecaminediol 614 µM -0.0799416568834378 0.470962241064065 no 1790 0.46814182921344 592 334274 A psychoactive constituent of the cannabis plant.
SGTC_554 4483-2211 187 µM -0.0810971130703752 0.47048732307234 no 1791 0.467682360781809 593 747107
SGTC_999 SEC7.066 22.7 µM -0.0827912708306659 0.469791062923606 no 1792 0.467008755083453 585 740511 YDR170C SEC7
SGTC_1201 1889-3372 45.9 µM -0.0839528889960291 0.469313717630051 no 1793 0.4665469443029 590 5392199
SGTC_2739 tacrine 100.86 µM -0.084286601317994 0.4691765929078 no 1794 0.466414282546115 588 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2472 5377652 49.4 µM -0.0845050934913763 0.469086814928268 no 1795 0.466327426654294 624 1610903
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0869749068796065 0.468072084135129 no 1796 0.465345728957922 586 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_604 1000-0114 314 µM -0.0873145208328387 0.467932568720581 no 1797 0.465210756073477 590 1572745
SGTC_1277 0873-0036 22 µM -0.0889963450774666 0.46724172378357 no 1798 0.464542407400529 595 5965735
SGTC_2140 5586273 200 µM -0.0892860375125276 0.467122736382197 no 1799 0.464427295099937 580 854421
SGTC_2265 7929201 200 µM -0.090959275271954 0.466435533546608 no 1800 0.463762475243756 605 1265108
SGTC_2715 st079500 56.4 µM -0.091370534908907 0.466266643448188 no 1801 0.463599086764268 590 28246688
SGTC_1534 6-azauridine 81.6 µM -0.0924128097424901 0.465838644523699 no 1802 0.463185031138911 588 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3182 9108849 49.47 µM -0.0924594028582788 0.465819512481872 no 1803 0.463166522417471 579 17133045
SGTC_106 0092-0003 11.579 µM -0.092968844386684 0.465610331020452 no 1804 0.462964156286746 609 1072148
SGTC_1192 1488-0095 21.4 µM -0.0934194227793082 0.465425327230004 no 1805 0.462785180422607 606 915875
SGTC_448 monastrol 171 µM -0.0943771324316782 0.46503212437635 no 1806 0.4624047901949 596 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_847 0342-0274 5.54 µM -0.0944061837025504 0.465020197448949 no 1807 0.462393251931041 605 18097
SGTC_1847 st056231 15 µM -0.0958203854456813 0.464439638625535 no 1808 0.461831613305776 598 5393180
SGTC_1384 3089-0840 101 µM -0.0959471179069062 0.464387616028268 no 1809 0.461781286247059 591 1069836
SGTC_1838 st055369 84.5 µM -0.0960184418761962 0.46435833841327 no 1810 0.461752962868371 581 676036
SGTC_2151 5563267 85.4165 µM -0.096295363906726 0.464244667145319 no 1811 0.461642996521992 589 5310824
SGTC_424 splitomicin 100 mM -0.0969257643652334 0.463985910551223 no 1812 0.461392674064751 624 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2342 7990637 118.86 µM -0.0988258538229846 0.463206085123595 no 1813 0.460638270295339 614 2033102 YER133W GLC7
SGTC_3269 9137823 49.47 µM -0.0993029841604517 0.46301028571187 no 1814 0.460448854556525 581 17682936
SGTC_3346 9158254 43.5805 µM -0.0995162392231544 0.462922775379098 no 1815 0.460364197433125 580 17639500
SGTC_1970 st070122 35.8 µM -0.100044126907438 0.462706161628056 no 1816 0.460154646473304 609 102928
SGTC_1369 1866-0067 208 µM -0.100244192116095 0.462624069635893 no 1817 0.460075231224877 605 3531355
SGTC_1158 4092-0494 91.8 µM -0.100642962082329 0.46246044863234 no 1818 0.459916945508882 616 1148199
SGTC_1183 1254-0324 198 µM -0.101092689271735 0.462275926776123 no 1819 0.459738440715867 597 5799357
SGTC_3026 9090633 49.47 µM -0.101159045253958 0.462248701781434 no 1820 0.459712103521767 605 25236842
SGTC_3344 9148862 3.898 µM -0.102142391966377 0.461845268241072 no 1821 0.459321826515669 619 4905352
SGTC_2666 tannic acid 100 µM -0.102558849740668 0.461674421661637 no 1822 0.459156551853516 588 16134267 A thiamine antagonist.
SGTC_1924 st058459 75.1 µM -0.10328167788829 0.461377907286276 no 1823 0.458869708386653 612 688683
SGTC_1650 st011916 45.8 µM -0.104628746895573 0.460825377851834 no 1824 0.458335201585687 588 242528
SGTC_26 0302-0163 425.158 µM -0.104647700323278 0.460817604231278 no 1825 0.458327681543977 604 3100915
SGTC_1070 indatraline 8.81 µM -0.104986789609183 0.460678531580447 no 1826 0.458193145575409 604 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.106684752343449 0.459982208978012 no 1827 0.457519539715288 590 140250 A respiratory chain inhibitor.
SGTC_670 4204-0025 119 µM -0.107465059720357 0.459662251425698 no 1828 0.457210021532602 592 719039
SGTC_790 1575-0012 79.1 µM -0.107531429877846 0.459635038182016 no 1829 0.457183696216902 629 378741 YLR208W SEC13
SGTC_2115 tiliquinol 12.7705 µM -0.107667299894123 0.459579329037344 no 1830 0.457129804794809 609 71208 A bioactive hydroxyquinoline.
SGTC_315 k915-0449 187 µM -0.108597917219758 0.459197780625608 no 1831 0.456760706401306 605 20970215 YNL149C PGA2
SGTC_155 k072-0202 43.6 µM -0.110049066728193 0.458602891762106 no 1832 0.456185230787733 583 5857737
SGTC_358 0075-0058 9.45 µM -0.110865515096215 0.45826823497571 no 1833 0.455861495973045 666 1069125
SGTC_639 0833-0042 114 µM -0.111134457134822 0.458158003877788 no 1834 0.455754862565751 596 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2017 5132927 60.65 µM -0.111149585112675 0.458151803478892 no 1835 0.455748864535884 611 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_352 k048-0007 5.11 µM -0.11181802176378 0.45787784619255 no 1836 0.455483848918307 616 6811911
SGTC_1743 st037606 46.3785 µM -0.111894805134994 0.457846377976205 no 1837 0.455453407819373 605 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.112260754462431 0.457696404181311 no 1838 0.455308329225671 589 2333 A French combination drug.
SGTC_369 0957-0393 4.5 µM -0.113238981063657 0.457295535804054 no 1839 0.454920545993752 642 6997992
SGTC_2860 9025725 38.96 µM -0.115231972469199 0.456478960880611 no 1840 0.454130628549337 641 40546248
SGTC_1757 st041620 31.8375 µM -0.115416621966902 0.45640331493617 no 1841 0.454057452290198 602 5289815
SGTC_564 3555-0129 330 µM -0.116583696558027 0.455925232457609 no 1842 0.453594978937472 603 563260
SGTC_2273 7815444 169.05 µM -0.116862442421294 0.455811055928208 no 1843 0.453484530386718 605 2824616
SGTC_2920 7982904 15.77 µM -0.116933610478731 0.455781905508527 no 1844 0.453456331768468 610 6456808
SGTC_669 0108-0021 26.2 µM -0.117588288966558 0.455513760539286 no 1845 0.45319694230794 673 17201
SGTC_974 1326-0144 138 µM -0.117691591156863 0.455471451599286 no 1846 0.45315601487919 622 5411856
SGTC_1763 st044482 94.5 µM -0.117708963334379 0.455464336616621 no 1847 0.453149132222514 601 88505
SGTC_40 0327-0103 19.753 µM -0.119929680476835 0.454554933813078 no 1848 0.452269426268535 615 409036
SGTC_161 4065-0411 162.148 µM -0.119929971422316 0.454554814683896 no 1849 0.452269311029817 629 1906281 YLR208W SEC13
SGTC_1740 st038286 13.222 µM -0.1200762681526 0.454494913223753 no 1850 0.452211365811646 604 716786
SGTC_1057 3448-5381 134 µM -0.12113858328587 0.454059977501125 no 1851 0.451790634574464 613 5497911
SGTC_1206 3978-0017 132 µM -0.121196943778794 0.454036084993407 no 1852 0.451767522392805 643 3873677
SGTC_959 1222-0044 107 µM -0.121418739505061 0.45394528439792 no 1853 0.451679687355878 616 6083612
SGTC_1931 st074438 57.1 µM -0.122945974433623 0.453320117750874 no 1854 0.451074939714081 615 2787313
SGTC_2364 9055074 200 µM -0.123319385368835 0.453167281227569 no 1855 0.450927095346683 617 6470630
SGTC_1126 isoteolin 1.0172 µM -0.123482218397987 0.453100636089119 no 1856 0.450862627093655 594 133323
SGTC_260 nsc-65238 3.989 µM -0.123743212248017 0.452993817942028 no 1857 0.450759298074664 600 3246252
SGTC_3073 9114972 49.47 µM -0.1261410988627 0.452012584073116 no 1858 0.449810117545913 599 41905075
SGTC_865 0488-0499 301 µM -0.126380462177883 0.451914650729695 no 1859 0.449715383531445 602 9634651
SGTC_1101 ebselen 5.29 µM -0.126464560836017 0.451880243215857 no 1860 0.449682100065615 598 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2960 9079389 5.97 µM -0.127809721213254 0.451329943374627 no 1861 0.44914977837361 624 16457355
SGTC_723 4182-0001 115 µM -0.129187888801465 0.450766237410057 no 1862 0.44860448961935 613 744821 YLR208W SEC13
SGTC_54 0159-0055 9 µM -0.129492465797223 0.45064167094756 no 1863 0.44848399309161 669 3319099
SGTC_1750 st081859 2.357 µM -0.129587453013301 0.450602823894354 no 1864 0.44844641529047 624 5291695
SGTC_1219 1469-0211 33.1 µM -0.130788519953774 0.45011166282992 no 1865 0.447971302366905 618 6822282
SGTC_2022 5136654 200 µM -0.13339242227671 0.44904709342919 no 1866 0.446941519000561 619 1713771
SGTC_2168 5727979 200 µM -0.134146607950016 0.448738823210616 no 1867 0.446643322433311 602 695210
SGTC_696 1560-0013 611 µM -0.135658407475958 0.448120974892725 no 1868 0.446045664848507 614 1650269
SGTC_1154 4088-0362 150 µM -0.137798003841144 0.447246771436213 no 1869 0.445200031007108 600 6618304
SGTC_1498 4478-3555 97.6 µM -0.138057892404874 0.44714060266317 no 1870 0.445097332010917 613 3437919
SGTC_1382 3002-2117 298 µM -0.139800690981198 0.446428738883242 no 1871 0.444408733666939 617 1497314
SGTC_1635 st007035 42.4 µM -0.140213846769217 0.446260006430075 no 1872 0.444245515920886 600 3716403
SGTC_3218 9131285 49.47 µM -0.140384061577465 0.446190493683579 no 1873 0.444178275081985 632 17156417
SGTC_2246 7293507 91.5585 µM -0.14066134817443 0.446077258236034 no 1874 0.444068740560338 593 887656
SGTC_2194 5927483 104.545 µM -0.140920764738305 0.445971324350225 no 1875 0.443966268976667 607 760979
SGTC_2740 felodipine 17.08 µM -0.141994561454663 0.445532875878778 no 1876 0.443542150745052 601 3333 L-type calcium channel blocker
SGTC_1444 4112-3581 28 µM -0.142246882885754 0.445429858624694 no 1877 0.443442500539511 598 2877249
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.142929835953997 0.445151042510011 no 1878 0.443172797400033 604 94937 An inhibitor of serotonin biosynthesis.
SGTC_3168 9103419 49.47 µM -0.145347751908637 0.444164145442873 no 1879 0.442218157210444 614 16649256
SGTC_1434 4073-0095 163 µM -0.148085997925555 0.443046920619838 no 1880 0.441137449822001 615 24133745
SGTC_2887 9044784 58.44 µM -0.148146733651701 0.443022145088779 no 1881 0.441113484105456 616 6465546
SGTC_2308 7584454 197.62 µM -0.149026040567339 0.442663480126552 no 1882 0.440766542500845 646 893577
SGTC_8 0354-0001 70 µM -0.149260088912506 0.442568020864153 no 1883 0.440674203431821 626 4993152
SGTC_574 1315-0397 40 µM -0.149774621505802 0.442358174661359 no 1884 0.440471216289446 605 6794277
SGTC_978 1416-0512 87.4 µM -0.150704722800172 0.44197888462073 no 1885 0.440104323766957 621 6814003
SGTC_327 1273-0057 3.96 µM -0.151437624266955 0.441680049004066 no 1886 0.439815255908916 626 3108138
SGTC_1477 0139-0234 16 µM -0.154028895160394 0.440623743101917 no 1887 0.438793476202555 617 620880
SGTC_2742 clothiapine 36.27 µM -0.154068801481007 0.440607478968902 no 1888 0.438777743670631 617 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3190 9110366 49.47 µM -0.154163515630563 0.440568877877771 no 1889 0.438740404274163 639 17123768
SGTC_3140 9094243 49.47 µM -0.154410526904876 0.440468210205487 no 1890 0.43864302696652 630 19291112
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.155680549526539 0.439950682486928 no 1891 0.438142414724511 652 5393153
SGTC_721 1187-1332 279 µM -0.155826386828671 0.439891261082416 no 1892 0.438084935502516 630 25730
SGTC_544 k015-0020 52.4 µM -0.156380493346231 0.439665502754509 no 1893 0.437866556029695 589 3008304
SGTC_2365 9042475 200 µM -0.157693840017651 0.439130487467985 no 1894 0.437349027356723 614 6464479
SGTC_3339 9145883 14.936 µM -0.158206535848579 0.438921661757982 no 1895 0.437147026876985 624 2030670
SGTC_1643 st009866 20.2 µM -0.159917055401052 0.438225074761532 no 1896 0.436473206578598 609 3156273 YOR207C RET1
SGTC_3316 9136639 10.545 µM -0.160111403296133 0.438145941156945 no 1897 0.436396659265989 638 4903665
SGTC_1769 st044406 64.4 µM -0.16024723847372 0.43809063393645 no 1898 0.436343159623048 627 670903
SGTC_2610 ononetin 44.17 µM -0.16038459287342 0.438034709372727 no 1899 0.436289062807899 642 259632
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.160468744597779 0.438000447168398 no 1900 0.436255920371741 613 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1695 st026914 34.495 µM -0.160798587923373 0.437866156609166 no 1901 0.436126018719126 626 3289191
SGTC_1490 4089-0339 670 nM -0.162706075560416 0.437089693626329 no 1902 0.435374931567366 637 742542
SGTC_1074 carmofur 3.8 µM -0.162840133518701 0.437035132995642 no 1903 0.435322154004471 621 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2670 beta-carotene 100 µM -0.162972053212681 0.436981443792297 no 1904 0.435270219384099 615 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1115 galangin 695.678 nM -0.1643893532035 0.436404698805351 no 1905 0.434712322235026 653 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2641 levomentholum 100 µM -0.164459082041692 0.436376327375496 no 1906 0.434684877954556 610 16666
SGTC_2179 6298986 200 µM -0.165376541017439 0.4360030601009 no 1907 0.434323808492228 628 738374
SGTC_3225 9130819 49.47 µM -0.16555701766419 0.435929640054228 no 1908 0.434252787661364 651 4547121
SGTC_3187 9109394 49.47 µM -0.167271446832141 0.435232300334393 no 1909 0.4335782348586 621 17098090
SGTC_653 0203-0016 55.2 µM -0.16768751240565 0.435063097000419 no 1910 0.433414560366994 640 295302
SGTC_486 niguldipine 82 µM -0.168099720436233 0.434895474156894 no 1911 0.433252414640489 605 1236 A calcium channel blocker.
SGTC_3086 9117350 49.47 µM -0.169399910752171 0.434366833456849 no 1912 0.432741046850011 601 2679265
SGTC_2006 4011487 200 µM -0.169808810466195 0.434200604289082 no 1913 0.432580248906355 626 45595294
SGTC_1265 0819-1001 68.8 µM -0.17003196087144 0.434109892314581 no 1914 0.432492500736732 634 3106768
SGTC_562 3772-2733 112 µM -0.171064336510536 0.433690270672138 no 1915 0.432086588910456 643 2876874 YIL048W NEO1
SGTC_75 0159-0059 199.013 µM -0.171562542802299 0.433487795364731 no 1916 0.431890728631767 604 5377270
SGTC_51 1013-0126 23.419 µM -0.171566294860936 0.433486270562096 no 1917 0.431889253645099 611 1627850
SGTC_2787 5284540 71.43 µM -0.174309835518825 0.432371586970023 no 1918 0.430810984974036 657 736958
SGTC_2988 9073640 71.4286 µM -0.174754863129359 0.432190825491128 no 1919 0.43063612823323 649 9102229
SGTC_787 4152-0075 138 µM -0.174759079748022 0.432189112851225 no 1920 0.430634471537641 604 9566539
SGTC_2290 7904846 200 µM -0.176324182348052 0.431553512355491 no 1921 0.430019632444927 638 2962154
SGTC_3353 9151644 39.2805 µM -0.17694343058405 0.431302079595023 no 1922 0.429776412071165 645 4909158
SGTC_3224 9130643 49.47 µM -0.178230129002039 0.430779731804306 no 1923 0.429271124498263 647 17644395
SGTC_2532 xanthone 78.9 µM -0.178817299086136 0.430541404549757 no 1924 0.429040580754084 652 7020 An insecticide.
SGTC_206 4546-0025 72.014 µM -0.179029565215759 0.430455253786204 no 1925 0.428957243516133 670 6620745 YIL048W NEO1
SGTC_2297 7971671 152.32 µM -0.179327664478783 0.430334272201594 no 1926 0.428840212908575 637 909016
SGTC_1315 1237-0019 3.69 µM -0.180108762771044 0.430017299747958 no 1927 0.428533591705259 616 825140
SGTC_1617 st002906 78 µM -0.18039250966853 0.429902165408141 no 1928 0.428422217143341 651 5150859
SGTC_3328 9140624 29.0385 µM -0.180666438869957 0.429791020392977 no 1929 0.428314701570332 622 4904392
SGTC_2998 9066762 71.4286 µM -0.180784983901438 0.429742923231817 no 1930 0.42826817500366 636 4945196
SGTC_1745 st081495 74 µM -0.181117156111271 0.429608156878515 no 1931 0.428137809332581 624 13842402 YBL026W LSM2
SGTC_1399 3562-5772 25 µM -0.182794569069327 0.428927735410411 no 1932 0.427479605035464 616 23847490
SGTC_957 1187-1561 14.1 µM -0.183784684670266 0.428526206442686 no 1933 0.427091185672394 635 1538454
SGTC_2812 7970281 58.44 µM -0.183921155971763 0.428470868008915 no 1934 0.427037653926187 653 2233435
SGTC_1947 st076332 61.6 µM -0.184052502101354 0.428417609135007 no 1935 0.426986133830514 653 24208416
SGTC_426 0988-0037 14.6 µM -0.184264735946231 0.428331554268542 no 1936 0.426902888421934 640 5383008
SGTC_802 4112-3352 742 µM -0.184702519360733 0.428154056152322 no 1937 0.426731185007238 612 704594
SGTC_221 trifluoperazine 10.304 µM -0.185315632487107 0.427905495513402 no 1938 0.426490738717535 633 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1899 st063254 59.6 µM -0.185521790850812 0.427821923795207 no 1939 0.426409895148166 631 3093813
SGTC_923 1900-2434 73.3 µM -0.185882103186586 0.427675869484546 no 1940 0.426268608596461 639 5910570
SGTC_2034 5197015 53.07 µM -0.186393941714776 0.427468410357183 no 1941 0.426067921497158 663 780676
SGTC_457 grayanotoxin iii 135 µM -0.187030969516554 0.427210237351384 no 1942 0.425818175602542 638 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2753 fluvastatin 17.09 µM -0.187097780344048 0.427183162233501 no 1943 0.425791984229533 639 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.187283644695363 0.427107842426339 no 1944 0.425719122873884 635 91467 include heat shock
SGTC_1233 0325-0408 14.2 µM -0.187340720220028 0.427084713631681 no 1945 0.4256967490002 651 12874
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.187564609226857 0.426993989197233 no 1946 0.425608985768652 612 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_67 0335-0847 266 µM -0.188470008543005 0.42662714218855 no 1947 0.425254111959423 696 4552207 YOR254C SEC63
SGTC_1872 amphotericin b 148 nM -0.189561741717944 0.426184881404345 no 1948 0.424826284620894 647 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1234 0326-0494 15.5 µM -0.190539778333767 0.42578875786453 no 1949 0.424443087745718 652 1547813
SGTC_593 1203-0218 61.7 µM -0.190632483164371 0.425751214513661 no 1950 0.424406769490584 648 3666956
SGTC_1138 3761-0006 1.03 µM -0.191402488388951 0.425439405930527 no 1951 0.424105135327347 632 12061087
SGTC_3194 9111903 49.47 µM -0.192533583903322 0.424981460798614 no 1952 0.423662131913681 651 17087251
SGTC_539 4859-0462 2.54 µM -0.194789382691358 0.424068461357966 no 1953 0.42277891723382 623 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1368 1852-0141 284 µM -0.195135585940118 0.423928376918776 no 1954 0.422643402238116 649 2838987
SGTC_897 1000-0139 31.4 µM -0.195965902395317 0.423592444649902 no 1955 0.422318427226563 657 6151020
SGTC_782 0083-0095 30.5 µM -0.19598431118318 0.423584997387892 no 1956 0.422311222865849 672 3591729 An indicator and reagent.
SGTC_1452 4194-0072 190 µM -0.196300107256357 0.423457246564211 no 1957 0.422187638722479 647 1343545
SGTC_1785 bathophenanthroline 24 µM -0.196479404465973 0.423384718000349 no 1958 0.422117475672756 629 72812 An iron chelator.
SGTC_2266 7929956 200 µM -0.196916531230774 0.423207904178203 no 1959 0.421946428454844 626 2967153
SGTC_740 k014-0057 261 µM -0.198089782211056 0.422733411323641 no 1960 0.42148740952375 658 4012779
SGTC_849 0386-0493 241 µM -0.198251450034137 0.422668037471159 no 1961 0.421424167473971 630 726119
SGTC_578 3460-0051 92 µM -0.198329276539969 0.422636567413258 no 1962 0.421393723624146 658 2876744
SGTC_2068 5226020 147 µM -0.198504429574422 0.422565744041563 no 1963 0.421325209705527 662 1810509
SGTC_680 0417-1641 114 µM -0.199204663898597 0.422282628353955 no 1964 0.421051325636902 625 2835990
SGTC_166 k072-0058 166.424 µM -0.199869547079848 0.422013842844819 no 1965 0.420791303887566 623 5846229
SGTC_3081 9117243 49.47 µM -0.19990804541913 0.421998280627008 no 1966 0.420776249058527 665 45595589
SGTC_1665 st014639 11.4 µM -0.200309111695479 0.42183616449863 no 1967 0.42061941842902 627 981133 YIL048W NEO1
SGTC_1428 4049-0204 61.7 µM -0.202524358974262 0.420940972505973 no 1968 0.419753408620696 650 X1428
SGTC_2279 7948423 32.93 µM -0.203048198528662 0.42072934600808 no 1969 0.41954867990556 621 1247112
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.204031493571436 0.420332165500983 no 1970 0.419164444110387 670 6728940
SGTC_2552 juarezic acid 87.02 µM -0.20454051294319 0.420126590103623 no 1971 0.418965568183923 635 1549512
SGTC_2591 skatole 100 µM -0.205194159774404 0.419862636617491 no 1972 0.418710216096158 657 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.205249338464523 0.419840356190861 no 1973 0.418688661688794 652 521171
SGTC_109 0132-0036 33.701 µM -0.207079499113567 0.419101507491118 no 1974 0.417973886209989 619 67274 A color developer.
SGTC_1481 3346-2004 36 µM -0.207241079745411 0.419036289919625 no 1975 0.417910793321596 647 2770522
SGTC_2728 chlorpromazine 9.18 µM -0.207245529329084 0.419034493999201 no 1976 0.417909055908799 627 2726 A thorazine and dopamine antagonist.
SGTC_3246 9135460 32.98 µM -0.21094226905658 0.417543019393462 no 1977 0.416466160104613 626 41446951
SGTC_1783 st039459 87.517 µM -0.211374638507936 0.417368654043042 no 1978 0.416297472595082 683 729761
SGTC_1019 4262-0212 3.4 µM -0.211853594015791 0.417175520502206 no 1979 0.416110627688123 637 4677213
SGTC_3293 9120939 62.045 µM -0.212233091672586 0.417022506433223 no 1980 0.415962595654491 680 934087
SGTC_2695 st077686 51.995 µM -0.212452942941904 0.416933867793898 no 1981 0.415876842921638 641 2876092
SGTC_1644 st010134 20.9 µM -0.21432382175516 0.416179746636632 no 1982 0.415147271272583 652 3818134
SGTC_512 prima-1 270 µM -0.215293981234917 0.415788812234517 no 1983 0.414769060943351 642 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_501 nsc-95397 161 µM -0.21607986297212 0.415472195256348 no 1984 0.414462747979305 660 262093
SGTC_885 0865-0106 16.8 µM -0.216309107254017 0.415379847373779 no 1985 0.414373405273222 643 2793380
SGTC_1789 tunicamycin 25 nM -0.216758901547228 0.415198667562269 no 1986 0.414198121131658 669 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2099 5377090 177.372 µM -0.216895733230005 0.415143554523452 no 1987 0.414144801424619 658 2243829
SGTC_3334 9142812 21.919 µM -0.217217988278096 0.415013763296098 no 1988 0.414019233363768 649 45283678
SGTC_2816 7982706 58.44 µM -0.218153659150871 0.41463696573293 no 1989 0.413654695051105 653 2981853
SGTC_1293 1000-1278 195 µM -0.220956364891765 0.413508778678391 no 1990 0.412563204499932 670 678847
SGTC_2899 9053889 58.44 µM -0.220971753644493 0.413502586128958 no 1991 0.41255721333538 642 6470052
SGTC_2090 5301565 104.445 µM -0.22309133044055 0.412649858750345 no 1992 0.411732212821484 657 2056344
SGTC_3136 9095672 49.47 µM -0.223776150390261 0.412374436579281 no 1993 0.411465744308459 621 17217380
SGTC_748 act1.228 77.9 µM -0.225417576722623 0.411714460547347 no 1994 0.410827219619195 641 4421505 YNR035C ARC35
SGTC_1870 st057514 26.5 µM -0.225815976328153 0.411554311722562 no 1995 0.410672275344967 623 5393161
SGTC_699 0375-0592 111 µM -0.226622680201471 0.411230077742398 no 1996 0.410358577419459 627 762578
SGTC_2748 diazoxide 86.69 µM -0.22789985622592 0.410716873572937 no 1997 0.409862047248451 631 3019 A potassium channel activatior.
SGTC_1151 3909-8316 15.3 µM -0.230151174679303 0.409812605000416 no 1998 0.408987150195046 688 800431
SGTC_184 1494-0393 24.714 µM -0.230308137722558 0.409749576770367 no 1999 0.40892616878875 655 3090647
SGTC_17 0960-0276 49.807 µM -0.230370987671693 0.409724340139159 no 2000 0.408901751695373 650 6821114
SGTC_2984 9022109 38.96 µM -0.231321735042092 0.409342624797408 no 2001 0.408532431210106 657 6459207
SGTC_2821 7996764 71.43 µM -0.232227372172961 0.408979100665039 no 2002 0.408180709445836 621 2987135
SGTC_1738 st035555 74 µM -0.232715550554931 0.408783177563801 no 2003 0.40799114655578 693 5331140
SGTC_209 4077-0173 175.592 µM -0.236080234985115 0.40743343412974 no 2004 0.406685205346995 624 15993494
SGTC_1168 k815-0004 80.5 µM -0.236532532741555 0.407252078236529 no 2005 0.406509732937208 640 642433
SGTC_69 0096-0274 206.684 µM -0.238035009884881 0.40664977933065 no 2006 0.405926970256479 669 6741392
SGTC_1962 st076595 64.5 µM -0.238633720154176 0.406409835420247 no 2007 0.405694807744671 657 279619
SGTC_2528 xanthyletin 44.79 µM -0.238843489737172 0.406325774794478 no 2008 0.405613473014654 640 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2139 5578692 56.4705 µM -0.239980267681857 0.405870310794436 no 2009 0.405172776894682 649 650991 YMR113W FOL3
SGTC_1445 4239-0156 97.7 µM -0.240550130748173 0.405642036076517 no 2010 0.40495190257103 694 4008346
SGTC_2137 5261020 140 µM -0.24077501558447 0.405551960940017 no 2011 0.404864747351611 655 763655
SGTC_1313 1220-0047 237 µM -0.24458554059161 0.404026461282951 no 2012 0.403388680503013 651 3528706
SGTC_2134 5324836 1.464 µM -0.244638166923759 0.404005403096177 no 2013 0.403368304444835 628 699272
SGTC_3065 9113888 49.47 µM -0.24512228022036 0.403811700426312 no 2014 0.403180875978661 689 16648368
SGTC_1663 st014140 55.4 µM -0.245491476792659 0.40366399391047 no 2015 0.403037953418307 659 4207120
SGTC_3214 9129694 49.47 µM -0.246407250037577 0.403297674784953 no 2016 0.402683497257276 676 17158655
SGTC_3272 9137413 49.47 µM -0.246788127176271 0.403145344803373 no 2017 0.4025360997448 691 17614870
SGTC_3150 9097574 49.47 µM -0.248163380981774 0.402595441150149 no 2018 0.402003998996841 698 17217476
SGTC_2131 toluylene red 5.2905 µM -0.248398489036519 0.402501451009107 no 2019 0.401913051264722 649 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2529 gangaleoidin 93.61 µM -0.248688808978183 0.402385396355417 no 2020 0.401800753040059 631 4565183
SGTC_1381 2324-0066 62.1 µM -0.248892273774622 0.402304066950625 no 2021 0.401722055956434 698 10885928
SGTC_1604 st002052 72.4 µM -0.249648050325188 0.402002003308489 no 2022 0.401429768019415 635 6254834 YHR062C RPP1
SGTC_131 0141-0277 33.849 µM -0.251682907079289 0.401189016955653 no 2023 0.400643084982874 687 1547771
SGTC_2525 harmine 47.85 µM -0.251943774631708 0.401084823390323 no 2024 0.400542261700858 657 5280953 A monoamine oxidase inhibitor
SGTC_2914 7968218 45.32 µM -0.253167388948153 0.400596191458391 no 2025 0.400069432814815 690 2977111
SGTC_820 1582-0060 59.9 µM -0.254030665460503 0.400251548510678 no 2026 0.399735933686205 659 3848840
SGTC_2533 agelasine 13.65 µM -0.254929541475058 0.399892775827869 no 2027 0.399388759551257 662 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_41 0478-0632 82.643 µM -0.255387072037879 0.399710191894266 no 2028 0.399212077417369 674 3750424
SGTC_2903 5923464 63.88 µM -0.255841299736989 0.399528947704603 no 2029 0.39903669115328 674 2876576
SGTC_3100 9120536 49.47 µM -0.255852470115524 0.399524490815709 no 2030 0.399032378306665 701 16421196
SGTC_3254 9136651 49.47 µM -0.257210127397776 0.398982894428485 no 2031 0.398508283210954 669 16454030
SGTC_4 0960-0234 25.671 µM -0.257345593482555 0.398928864973964 no 2032 0.398455999397474 638 6821112
SGTC_368 fentichlor 4.58 µM -0.25774536760919 0.398769429879197 no 2033 0.398301715201901 698 7329 A pesticide.
SGTC_707 0865-0008 204 µM -0.258249922243467 0.398568231076644 no 2034 0.398107015926191 659 723043
SGTC_3230 9131665 49.47 µM -0.258503763403048 0.398467018258518 no 2035 0.398009072416254 665 15943720
SGTC_1787 fluconazole 80 µM -0.258878568154383 0.398317586719652 no 2036 0.397864467381302 664 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.259369525438575 0.398121868691414 no 2037 0.397675070266354 710 688798
SGTC_3138 9097216 49.47 µM -0.260048750440121 0.39785114080712 no 2038 0.397413084683411 662 25237486
SGTC_3342 9147791 14.508 µM -0.260341561008319 0.397734446506678 no 2039 0.397300158249548 657 1838168
SGTC_1855 st056195 39.6 µM -0.260434055144922 0.397697586560132 no 2040 0.397264488398783 633 4028379
SGTC_254 nsc-64875 3.808 µM -0.260862659064525 0.397526795037292 no 2041 0.397099210894593 683 56993
SGTC_776 4476-4378 112 µM -0.262447326403024 0.396895502304666 no 2042 0.396488294885584 691 2892008
SGTC_1360 1598-0022 39.8 µM -0.26253043666439 0.396862400648149 no 2043 0.396456261475078 685 761525
SGTC_1116 jasmonic acid 1.58368 µM -0.262547114015541 0.396855758381589 no 2044 0.396449833563173 691 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.263344618148083 0.396538162866402 no 2045 0.396142486319769 668 4213774
SGTC_2250 alverine citrate 130 µM -0.263903470464227 0.396315648178237 no 2046 0.395927150689568 648 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2142 5622915 118.518 µM -0.264206161300058 0.396195141779185 no 2047 0.39581053183881 644 5322196
SGTC_2709 st078560 56 µM -0.264279930596384 0.396165774463211 no 2048 0.395782111874154 679 17250903
SGTC_140 0062-0056 502.533 µM -0.265232195825482 0.395786733738011 no 2049 0.395415297054124 667 3758964
SGTC_1025 k007-0731 70 µM -0.265951916406132 0.395500320702973 no 2050 0.395138120431205 639 6256118
SGTC_2867 9039098 71.43 µM -0.26603213669631 0.395468400505503 no 2051 0.395107229518141 659 6463460
SGTC_1357 1503-1303 39.5 µM -0.266253477345066 0.395380331197697 no 2052 0.395021999953207 655 292895
SGTC_1705 st027868 56.3335 µM -0.266735798378941 0.395188438825798 no 2053 0.394836294524903 672 292948
SGTC_341 1486-1430 230 µM -0.267430638077816 0.39491204017508 no 2054 0.394568806206665 669 2054753 YPL210C SRP72
SGTC_1766 st045414 44.774 µM -0.267548057081721 0.394865337564628 no 2055 0.394523609014795 657 253960
SGTC_1777 st045864 34.765 µM -0.267790934089028 0.394768739681037 no 2056 0.394430124747536 653 4691462
SGTC_1305 1181-0477 144 µM -0.267918944506199 0.394717829537964 no 2057 0.394380855506283 659 6252086
SGTC_1804 st050076 49.1 µM -0.268490102913915 0.394490699971655 no 2058 0.39416104601694 658 3895976
SGTC_792 4534-1957 155 µM -0.268937524848141 0.394312801087059 no 2059 0.393988879870884 655 1717904
SGTC_767 0929-0023 86 µM -0.269313125904097 0.394163475831815 no 2060 0.393844366100516 645 1204563
SGTC_1485 3909-9022 254 µM -0.269599698127194 0.394049555648005 no 2061 0.393734116303123 671 714516
SGTC_92 0063-0024 660.874 µM -0.270043980693692 0.393872959274444 no 2062 0.393563209171731 670 3594437
SGTC_332 4112-0506 40.9 µM -0.271280763061329 0.393381469868553 no 2063 0.393087550381831 655 2790355
SGTC_3300 9124615 50.48 µM -0.271308865649859 0.393370304050206 no 2064 0.393076744152916 679 24824903
SGTC_934 2950-0684 338 µM -0.271966338146375 0.393109099833881 no 2065 0.392823951173772 702 1121253
SGTC_1472 k841-0093 193 µM -0.272205616465388 0.393014049989663 no 2066 0.392731961763547 691 X1472
SGTC_397 arbidol 50 µM -0.272492098532055 0.392900257530888 no 2067 0.392621832978602 657 131410 A RNA synthesis inhibitor.
SGTC_1996 st072960 66.8 µM -0.274084427616226 0.392267941575062 no 2068 0.392009870367376 644 1719405
SGTC_1721 st082152 9.2685 µM -0.274739697278727 0.39200781562417 no 2069 0.391758115136453 663 5296051
SGTC_2938 9059746 27.26 µM -0.275573165171032 0.391677019100216 no 2070 0.391437961469698 693 6471769
SGTC_2932 9016711 44.54 µM -0.275676929202942 0.391635841489249 no 2071 0.391398108525666 697 7117328
SGTC_1029 k015-0030 64.7 µM -0.276092008475923 0.39147113400694 no 2072 0.391238699265061 668 2208316
SGTC_412 gemfibrozil 100 µM -0.277245132026484 0.391013665583831 no 2073 0.390795943482554 658 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1027 k015-0025 8.67 µM -0.277666758677332 0.390846435008735 no 2074 0.390634090118047 654 3598955
SGTC_321 4534-3890 65.3 µM -0.27869296703118 0.390439492456195 no 2075 0.39024023012943 676 699746
SGTC_1940 st075990 51.1 µM -0.278927880120788 0.390346354617582 no 2076 0.390150086033776 686 1084979
SGTC_716 1683-5115 658 µM -0.279409293984391 0.390155504347501 no 2077 0.389965369715894 700 723597
SGTC_200 k038-0079 37.545 µM -0.281247945933059 0.389426838671252 no 2078 0.389260116284817 675 3436683
SGTC_2285 7945142 200 µM -0.28150716903094 0.389324138638927 no 2079 0.389160715116032 703 2970608
SGTC_3287 9117173 37.0625 µM -0.282098198295638 0.389090011242227 no 2080 0.388934107352135 654 2789709
SGTC_2915 7971052 15.16 µM -0.282429961635238 0.388958605800397 no 2081 0.38880692182814 678 5741558
SGTC_791 1348-1292 225 µM -0.282615293381184 0.388885204785623 no 2082 0.388735877829202 698 5437054
SGTC_2692 st077426 47.7 µM -0.283759717649417 0.388432041182409 no 2083 0.388297263370075 714 25238571
SGTC_684 1140-0066 328 µM -0.283779590246009 0.388424173466732 no 2084 0.38828964821321 689 6813534
SGTC_138 0850-0259 40.9225 µM -0.28394694252008 0.388357919215129 no 2085 0.38822552071219 682 6813004
SGTC_2968 9090663 33.37 µM -0.284335008174166 0.388204297716712 no 2086 0.388076830065498 714 25236811
SGTC_3152 9099253 49.47 µM -0.284695598830305 0.388061568276046 no 2087 0.387938681401411 672 25236131
SGTC_1706 st031321 9.9705 µM -0.285445485322385 0.387764795709596 no 2088 0.38765143204119 661 6103185
SGTC_1294 1000-1494 117 µM -0.285518731215722 0.387735811671544 no 2089 0.387623377973639 652 712797 YDL207W GLE1
SGTC_2712 st079126 47.7 µM -0.286233591837148 0.387452967964159 no 2090 0.387349608491562 684 3152970
SGTC_2654 protoveratrine a 100 µM -0.287210724989591 0.387066449432106 no 2091 0.386975487383995 684 5702278 A heart drug and vasodilator.
SGTC_2791 5663188 71.43 µM -0.287663753774401 0.386887285593185 no 2092 0.386802069006539 703 54690634
SGTC_1861 st057647 17.4 µM -0.287788515562713 0.386837949027917 no 2093 0.386754314448076 693 688668
SGTC_2994 9053520 71.4286 µM -0.292149512648953 0.3851145640425 no 2094 0.385086155741655 717 4647384
SGTC_1658 st012944 20 µM -0.292177326693569 0.385103579688073 no 2095 0.385075523162104 703 24207260
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.292855538679086 0.384835767984026 no 2096 0.384816287272038 660 88881 An O-methylated flavonoid and antioxidant.
SGTC_2191 5911152 200 µM -0.292990029191628 0.384782667021534 no 2097 0.384764886497291 672 2875902
SGTC_2664 lyso-paf C-16 73.48 µM -0.293364462812657 0.38463484057786 no 2098 0.384621792812664 678 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2478 5763493 32.33 µM -0.293507814142388 0.38457824989234 no 2099 0.384567013777502 658 1365576 YLR208W SEC13
SGTC_2326 6164455 177.58 µM -0.293952788529532 0.384402603393772 no 2100 0.38439698980568 680 2888790
SGTC_3200 9114385 49.47 µM -0.294417304843246 0.384219268351666 no 2101 0.384219522621069 689 17018030 YLR208W SEC13
SGTC_2021 4019055 173 µM -0.294667676276432 0.384120462632561 no 2102 0.384123878964639 699 44827708 YER133W GLC7
SGTC_3317 9138495 8.753 µM -0.295084087040747 0.383956148404703 no 2103 0.383964822739854 664 17020139
SGTC_2106 5357045 167.29 µM -0.295588306118776 0.383757213246056 no 2104 0.383772252575999 675 668842
SGTC_2121 5257820 149.641 µM -0.296023348328215 0.383585595820702 no 2105 0.383606125340203 676 791256
SGTC_2398 5228213 48.84 µM -0.296234217762291 0.38350241930384 no 2106 0.38352560945609 686 80771 YMR134W ERG29
SGTC_662 k832-1615 104 µM -0.296344363154817 0.383458975074489 no 2107 0.383483554844997 687 5878478
SGTC_2083 5306046 65.942 µM -0.297837566869686 0.382870161184308 no 2108 0.382913570385599 684 539837
SGTC_1655 st012546 55.1 µM -0.298803494956839 0.382489411534212 no 2109 0.382544992057145 684 720985 YLR208W SEC13
SGTC_920 mycophenolic acid 780.421 nM -0.300398595877456 0.381860903239124 no 2110 0.381936567292914 673 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2045 5106652 78.05 µM -0.300507855155744 0.381817863816301 no 2111 0.381894902805156 673 673349
SGTC_848 0368-0089 85.6 µM -0.302721143932478 0.380946320149479 no 2112 0.381051191440845 700 762535
SGTC_118 0083-0097 135.343 µM -0.303823042845831 0.380512641772719 no 2113 0.380631355215793 681 5207356
SGTC_101 0490-5701 117.494 µM -0.303847918407746 0.380502853137814 no 2114 0.380621878959434 695 4661669
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.305351863243171 0.37991118708315 no 2115 0.380049089817232 689 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2196 6573537 42.6665 µM -0.305711639186391 0.37976968943726 no 2116 0.379912105274299 711 2903087
SGTC_117 lucigenin 22.078 µM -0.306084307051175 0.379623138450655 no 2117 0.379770228022958 712 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_64 000l-0018 272.079 µM -0.30636917021274 0.379511128168595 no 2118 0.379661789545284 695 6811119
SGTC_2595 hexamethylquercetagetin 100 µM -0.306678711609076 0.379389425687298 no 2119 0.379543967565964 723 386331
SGTC_23 0213-0011 39.996 µM -0.307894132457724 0.378911674007789 no 2120 0.379081445340081 698 627608
SGTC_2986 9022445 71.43 µM -0.308973485937539 0.378487562034699 no 2121 0.378670847917809 717 6459286
SGTC_2870 9038528 12.99 µM -0.312692006782468 0.377027561418618 no 2122 0.377257334465545 695 6463316
SGTC_614 0462-0418 107 µM -0.31333921143261 0.376773628717966 no 2123 0.377011481264027 678 5188303
SGTC_1634 st006576 41 µM -0.314779405474954 0.376208755647709 no 2124 0.376464574739991 705 3915356
SGTC_297 0986-0032 24 µM -0.316295554571196 0.375614377887912 no 2125 0.375889092516018 699 2847425
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.316400026756931 0.375573432382077 no 2126 0.375849448327223 648 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_616 4092-0450 108 µM -0.318894706645945 0.374596116370651 no 2127 0.374903179209874 687 787165
SGTC_230 MPP+ 141.667 µM -0.320463459853941 0.37398195333274 no 2128 0.374308512876254 700 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1006 4099-6547 255 µM -0.321888216081989 0.373424441784371 no 2129 0.373768690344024 686 3146833
SGTC_891 0929-0073 133 µM -0.322565957572509 0.37315933230958 no 2130 0.373511989279528 713 5603632
SGTC_666 0272-0154 136 µM -0.323020631903064 0.372981512781804 no 2131 0.373339808475801 682 6870312
SGTC_2249 haloperidol 116.36 µM -0.323282216492216 0.372879221380556 no 2132 0.373240760359962 698 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1844 rapamycin 4 nM -0.32381847334938 0.372669548730481 no 2133 0.37303773471506 706 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1276 0871-0068 94.2 µM -0.324360994011376 0.372457465363636 no 2134 0.37283237348026 678 3414906
SGTC_277 nystatin 15.5 µM -0.326071268337306 0.371789134550802 no 2135 0.372185217302482 721 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1496 4469-0713 57.4 µM -0.326204907818578 0.37173692795217 no 2136 0.372134664207193 722 746691
SGTC_901 1112-0062 60.1 µM -0.326818938810193 0.3714970855341 no 2137 0.371902417119857 675 1908457
SGTC_3131 9127911 49.47 µM -0.328151307510606 0.370976829827701 no 2138 0.371398631025146 718 45595681
SGTC_1704 st028805 70.8 µM -0.328172248647678 0.37096865473166 no 2139 0.371390714662046 694 2876101
SGTC_758 0868-0029 16 µM -0.32957399735701 0.37042156630259 no 2140 0.370860936454564 663 762687
SGTC_692 k241-0027 77.8 µM -0.330721183357012 0.369974026013239 no 2141 0.370427549942077 714 3600480
SGTC_2619 obliquin 87.91 µM -0.331367454178213 0.369721980264416 no 2142 0.370183472655208 683 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3034 9090421 49.47 µM -0.331522185964653 0.369661643136176 no 2143 0.370125042808123 706 17173761
SGTC_654 1124-0271 80.9 µM -0.331714871139597 0.369586510701202 no 2144 0.370052285185398 699 5403748
SGTC_1068 loratadine 26.9 µM -0.331842029323507 0.369536931492404 no 2145 0.370004272999566 702 3957 A H1 histamine antagonist.
SGTC_3157 9099274 49.47 µM -0.331859083837091 0.369530282071286 no 2146 0.369997833737382 684 17217662
SGTC_1314 1222-0010 41.1 µM -0.333338821784347 0.368953492627413 no 2147 0.3694392689343 694 3526027
SGTC_1297 1068-0111 14.1 µM -0.333408246627666 0.368926438640487 no 2148 0.369413069513954 683 767057
SGTC_364 0083-0097 67.7 µM -0.333963484962217 0.368710092632085 no 2149 0.369203556516025 711 5207356
SGTC_1223 0764-0573 147 µM -0.334396948734515 0.368541224422598 no 2150 0.3690400207901 683 1609797
SGTC_1426 4048-4480 71.7 µM -0.334825245030344 0.368374394283758 no 2151 0.368878457912324 697 14224343
SGTC_474 dl-dihydrosphingosine 5 µM -0.335162468652058 0.368243056265648 no 2152 0.368751265970719 679 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1047 2043-3044 82 µM -0.336032962745935 0.367904097333922 no 2153 0.368423004814414 752 669592
SGTC_1865 st057639 52.2 µM -0.336779612828304 0.36761344354802 no 2154 0.368141521408855 673 688818
SGTC_1443 4112-3303 14 µM -0.337686613122586 0.367260471086072 no 2155 0.367799681978563 693 704433
SGTC_799 1310-0557 151 µM -0.338570996976347 0.366916408120782 no 2156 0.367466467259015 729 5354492
SGTC_86 0417-1630 471.922 µM -0.339447611303387 0.366575473297455 no 2157 0.36713627835865 692 3634867
SGTC_2007 4011539 71.82 µM -0.339614283088137 0.36651066283088 no 2158 0.367073510235497 686 45595301
SGTC_610 4215-0184 155 µM -0.342388640961152 0.365432411703136 no 2159 0.366029217855065 698 5605015
SGTC_1914 st062367 72.6 µM -0.34250785147478 0.365386104420268 no 2160 0.365984368149755 703 978205
SGTC_560 2332-1943 155 µM -0.343751147358813 0.364903263634003 no 2161 0.365516721220409 697 21177716
SGTC_3204 9114183 49.47 µM -0.343819445164678 0.364876746004443 no 2162 0.36549103781851 674 17027248
SGTC_3149 9097855 49.47 µM -0.34590975923303 0.364065463923418 no 2163 0.364705267043481 682 25236625 YMR079W SEC14
SGTC_2119 5528445 120.635 µM -0.346241507224333 0.363936763465609 no 2164 0.364580611671053 696 791935
SGTC_1022 4477-0945 21.3 µM -0.346615037235812 0.363791872189364 no 2165 0.364440273707187 688 4648966
SGTC_280 3448-3607 3.04 µM -0.346860513021007 0.36369666340284 no 2166 0.364348056547225 705 626179
SGTC_2375 9072683 200 µM -0.346889336239123 0.363685484751912 no 2167 0.364337229129374 736 16798029
SGTC_1910 st062352 60.4 µM -0.349259412049787 0.36276668443588 no 2168 0.363447283297892 673 2245730
SGTC_329 k048-0121 21.3 µM -0.349986642460314 0.362484919217519 no 2169 0.363174361123923 695 6832902
SGTC_2429 5902844 64.44 µM -0.350434648307863 0.362311376535981 no 2170 0.363006263652823 714 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2676 harmalol 100 µM -0.350858411116427 0.362147250845043 no 2171 0.362847286762024 683 5459187 A monoamine oxidase inhibitor
SGTC_2023 5144124 124 µM -0.352049024810579 0.361686255254593 no 2172 0.362400748218784 706 2830192
SGTC_861 0443-0273 110 µM -0.352314085650317 0.361583653217051 no 2173 0.362301362848374 704 6149169
SGTC_1033 k072-0102 21.3 µM -0.352324508809991 0.36157961873376 no 2174 0.362297454842469 726 5965931
SGTC_1828 st055811 49 µM -0.352701419643425 0.361433738530258 no 2175 0.362156147477674 728 5877589
SGTC_1830 st055982 50.3 µM -0.352723856499296 0.3614250551668 no 2176 0.362147736284644 737 455313 An antimicrobial agent.
SGTC_1999 st074831 12.5 µM -0.354602530024603 0.360698236982765 no 2177 0.361443690248591 748 17112523
SGTC_1274 0865-0114 173 µM -0.355234184957739 0.360453976176698 no 2178 0.361207078363012 683 870624
SGTC_2339 9000433 200 µM -0.355466128030383 0.360364298134761 no 2179 0.361120208031626 671 2988954
SGTC_2037 5169046 200 µM -0.355662688184224 0.360288306492117 no 2180 0.361046595376756 699 5718022
SGTC_1752 st044819 83.042 µM -0.35586487351395 0.360210145872336 no 2181 0.360970881437464 687 441209 YML126C ERG13
SGTC_1017 4239-0030 168 µM -0.356102491341893 0.360118295258205 no 2182 0.360881905773675 673 1149593
SGTC_2708 st078559 56 µM -0.357851279263067 0.359442554097255 no 2183 0.360227306457277 704 17250902
SGTC_2828 7998861 71.43 µM -0.357859299201252 0.359439456159962 no 2184 0.360224305408028 691 2988188
SGTC_2005 4024620 188 µM -0.358176588510054 0.359316901236035 no 2185 0.360105583121057 721 236743
SGTC_1061 3448-9325 110 µM -0.358310581505816 0.359265149972719 no 2186 0.360055450106653 737 723482
SGTC_447 ml7 120 µM -0.358722781925026 0.359105964615798 no 2187 0.359901241844484 709 4216 Selective myosin light chain kinase inhibitor.
SGTC_2845 9003024 42.97 µM -0.360454665220341 0.358437405925082 no 2188 0.359253576552422 687 2990173
SGTC_2565 isoliquiritigenin 100 µM -0.360567943852805 0.358393692077576 no 2189 0.359211228271687 669 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1968 st069590 43.6 µM -0.360762227231196 0.358318723088893 no 2190 0.359138601063497 710 6384066
SGTC_937 3122-0005 46.7 µM -0.361050042708099 0.35820767249304 no 2191 0.359031018948732 721 759535
SGTC_626 0214-0009 33 µM -0.361454643831438 0.358051581657926 no 2192 0.358879802607588 718 3437874
SGTC_1130 3454-2858 15.9 µM -0.361561868546534 0.358010219472531 no 2193 0.358839731958232 750 715628 YIL048W NEO1
SGTC_1776 st049249 45.9 µM -0.36195660063794 0.357857965007365 no 2194 0.358692231117679 688 1822314
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.362080715980536 0.357810096410809 no 2195 0.358645856882567 699 688788
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.363214741973592 0.357372830807912 no 2196 0.358222238021588 701 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1806 st050005 60.3 µM -0.364622829844461 0.356830151095777 no 2197 0.357696485349599 698 5194765
SGTC_237 nikkomycin 200 µM -0.365176907803573 0.356616687750344 no 2198 0.357489677335281 733 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_27 0485-0001 32.618 µM -0.365734372005246 0.356401965138773 no 2199 0.357281647640634 693 2054479
SGTC_1259 0671-0132 43 µM -0.366862607447498 0.355967533676414 no 2200 0.356860752275144 698 X1259
SGTC_1937 st074714 47.2 µM -0.368044648893805 0.355512584528057 no 2201 0.356419971080999 714 17250970
SGTC_888 0916-0002 6.97 µM -0.368159446641174 0.355468411635097 no 2202 0.356377173406413 695 2802138 YIL048W NEO1
SGTC_418 lividomycin a 100 µM -0.3683147287846 0.355408663887179 no 2203 0.356319285648227 707 72394 An antibiotic.
SGTC_348 k064-0012 10.7 µM -0.368553283117747 0.355316882509119 no 2204 0.35623036123203 698 5066323
SGTC_3112 9123419 49.47 µM -0.369560368407314 0.354929509126921 no 2205 0.355855042526742 735 17015854
SGTC_1711 st032263 62.8 µM -0.370151553577399 0.354702180717733 no 2206 0.35563478575211 709 3958979
SGTC_3061 glucosamine 200 µM -0.373131722585396 0.353557005644776 no 2207 0.354525204817921 704 91431 and experimental redox chemotherapeutic
SGTC_1471 k673-0312 37 µM -0.373300511871526 0.353492185333659 no 2208 0.354462397760903 706 24099884
SGTC_2497 7-hydroxyflavone 100 µM -0.373661322496277 0.353353637134381 no 2209 0.354328152195578 705 5281894
SGTC_2291 7917025 104.35 µM -0.37408985660579 0.353189108940234 no 2210 0.354168732500072 699 2964612
SGTC_2378 9074213 121.43 µM -0.374352177923364 0.353088408783827 no 2211 0.354071158512732 700 657714
SGTC_2181 6316240 54.2555 µM -0.376868338004394 0.352123026365855 no 2212 0.353135726050992 697 12779990
SGTC_1531 st059297 52.4 µM -0.377790583783767 0.351769423798092 no 2213 0.35279308464545 696 7566702
SGTC_22 0964-0034 14.468 µM -0.378679057456942 0.35142889117314 no 2214 0.352463103451318 724 138402
SGTC_1714 st033236 13.627 µM -0.379091108560053 0.351271001400202 no 2215 0.352310104374729 724 2916566
SGTC_1145 3546-0597 10.2 µM -0.379281863985496 0.351197916411114 no 2216 0.352239282892056 692 875334
SGTC_1936 st074407 74.3 µM -0.381026103451806 0.350529893559072 no 2217 0.351591939605116 698 809813
SGTC_127 0180-0333 59.125 µM -0.382758051669583 0.349867035167504 no 2218 0.350949583537818 692 771601
SGTC_1241 0364-0022 50.8 µM -0.383962698338909 0.349406257325952 no 2219 0.350503047365929 705 4563895
SGTC_1088 bifonazole 369 nM -0.384246180701192 0.349297857426032 no 2220 0.350397996648069 720 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1243 0416-0003 5.65 µM -0.384742519175842 0.349108093773986 no 2221 0.350214094905345 724 2141977
SGTC_1774 st048371 48.465 µM -0.386943737495685 0.348266963553672 no 2222 0.349398930267119 707 4242727
SGTC_381 3461-2219 42.7 µM -0.388595342876332 0.347636341015668 no 2223 0.348787756196074 756 2883159
SGTC_3259 9138485 49.47 µM -0.390185293213944 0.347029657863384 no 2224 0.348199767908821 702 17646153
SGTC_15 0266-0086 27.098 µM -0.391105845246741 0.346678578488504 no 2225 0.34785950009943 735 1712902 YIL048W NEO1
SGTC_722 3534-0461 190 µM -0.392322852450347 0.346214639358295 no 2226 0.347409840270529 701 658262
SGTC_2625 euphol 100 µM -0.392602264389487 0.34610815639361 no 2227 0.347306633422117 720 6708538 A triterpene alcohol.
SGTC_1072 oxiconazole 14.9 nM -0.393629839957179 0.345716655450978 no 2228 0.346927173568669 704 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2293 7624732 200 µM -0.394794556436334 0.345273103959636 no 2229 0.346497256313082 722 894453
SGTC_763 3453-1109 128 µM -0.394840545814772 0.345255594475991 no 2230 0.346480284880679 736 1560353
SGTC_3088 9117578 49.47 µM -0.394929763020354 0.345221627855536 no 2231 0.346447361988306 719 678341
SGTC_2377 9073351 62.6 µM -0.395178733937719 0.3451268466727 no 2232 0.346355492990361 750 7337946 YHR072W ERG7
SGTC_1172 0370-0043 85 µM -0.395512744041567 0.344999707029298 no 2233 0.346232259163787 723 376585
SGTC_2035 5154463 94.595 µM -0.396095565167839 0.344777900349546 no 2234 0.346017264907305 749 2769623
SGTC_490 phenamil 164 µM -0.396774094351199 0.344519736856273 no 2235 0.3457670278611 714 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_411 enrofloxacin 100 µM -0.397090156882436 0.344399507628543 no 2236 0.345650489093729 716 71188 A bacterial gyrase inhibitor.
SGTC_2164 5685496 200 µM -0.397668930060694 0.34417938482716 no 2237 0.345437121417366 712 759046
SGTC_3330 9141424 71.43 µM -0.399210664735201 0.343593279952634 no 2238 0.344868992863181 700 27261020
SGTC_736 0958-0254 92.6 µM -0.399815648577138 0.343363392269811 no 2239 0.34464615201688 757 6812352
SGTC_1196 1588-0294 184 µM -0.399883237442195 0.343337712787784 no 2240 0.344621259557301 744 6144269
SGTC_90 0870-0863 4.608 µM -0.400187943765248 0.343221952691933 no 2241 0.344509046914892 736 1738164
SGTC_2738 aclarubicin 5.55 µM -0.400839277827781 0.342974555593944 no 2242 0.344269229337716 712 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_765 1319-0117 244 µM -0.402798864844209 0.342230649223233 no 2243 0.343548098149625 695 3487746 YGL099W LSG1
SGTC_1703 st026983 48.3 µM -0.403331211470843 0.342028663197745 no 2244 0.343352291914214 728 1104023
SGTC_1953 st076800 12.1 µM -0.403410300855249 0.341998658502677 no 2245 0.343323205065315 715 297591
SGTC_186 3455-3465 67.277 µM -0.405032197629073 0.341383568411598 no 2246 0.342726921963527 732 755278
SGTC_1610 st001799 48.1 µM -0.405261754933235 0.34129654480341 no 2247 0.342642557849795 695 621897
SGTC_988 1497-1057 103 µM -0.405888745350982 0.341058900025886 no 2248 0.342412173944898 758 3533044
SGTC_2385 9074692 200 µM -0.40912299078523 0.339834044586245 no 2249 0.341224702467985 713 17046906
SGTC_2795 7780010 54.55 µM -0.409520251284474 0.339683712519418 no 2250 0.341078954103837 706 953673
SGTC_2922 7999257 32.47 µM -0.410010559667385 0.339498204255439 no 2251 0.340899100688349 718 2988377
SGTC_1933 st074711 15.9 µM -0.411235303197521 0.339034992269264 no 2252 0.340450002046094 726 17250958
SGTC_2435 5706476 10.6 µM -0.411364704005094 0.338986065601705 no 2253 0.340402565533376 704 5725375
SGTC_2203 7227154 166.4 µM -0.41183031252998 0.338810040690204 no 2254 0.340231900902029 714 896304
SGTC_168 3970-0862 530.542 µM -0.41330125236551 0.338254178181278 no 2255 0.339692956212431 729 3135186
SGTC_954 1189-0853 2.85 µM -0.414721919817111 0.337717647859157 no 2256 0.339172741998348 738 2828194
SGTC_642 0335-0876 158 µM -0.417170434263897 0.336793714170736 no 2257 0.338276874589794 723 6812350
SGTC_1359 1582-0056 520 nM -0.417956519153519 0.336497297701374 no 2258 0.337989454002016 750 3661189
SGTC_2913 7966556 36.57 µM -0.418353490861992 0.336347646410926 no 2259 0.337844342899666 746 2976516
SGTC_1336 1486-0901 104 µM -0.418685665121244 0.336222442530446 no 2260 0.337722936711231 702 5006114
SGTC_1308 1187-1617 41.4 µM -0.41872755110002 0.336206656061013 no 2261 0.337707629026223 730 2882570
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.418989320396779 0.33610800398176 no 2262 0.337611968681777 714 16486 A toxic proline analog.
SGTC_98 0074-0023 107.663 µM -0.420078068053241 0.335697812625969 no 2263 0.337214211969989 749 3563821
SGTC_648 0375-0473 33.3 µM -0.420297481609813 0.335615171101811 no 2264 0.33713407470976 726 1713139
SGTC_829 1635-0120 117 µM -0.423426779820307 0.33443739635628 no 2265 0.335991954842573 743 285054
SGTC_1435 4092-0789 56.7 µM -0.423535366764181 0.334396556616572 no 2266 0.335952350271815 731 2248285
SGTC_1050 3232-1156 69.3 µM -0.423698662940852 0.334335144328496 no 2267 0.335892795205727 744 700529
SGTC_405 ebelactone b 50 µM -0.42413520820653 0.334170990527153 no 2268 0.335733604841161 725 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_838 0109-0203 71.4 µM -0.424564858487212 0.334009460407663 no 2269 0.335576957575506 714 759422
SGTC_3238 9133470 49.47 µM -0.425837161097694 0.333531309496256 no 2270 0.335113253268776 722 3534688
SGTC_3279 9140807 49.47 µM -0.42664209820786 0.333228941282222 no 2271 0.334820014999545 725 45595718
SGTC_246 cycloheximide 667 µM -0.428203791677981 0.332642612758575 no 2272 0.334251378001351 723 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2571 chrysanthemic acid 100 µM -0.429540226859155 0.332141180912657 no 2273 0.333765062865536 779 2743 An insecticide.
SGTC_2248 tofa 1.1 µM -0.430150720735573 0.331912222884274 no 2274 0.333543003190654 735 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2118 5526350 200 µM -0.430161882394978 0.33190803742861 no 2275 0.333538943816213 742 743594
SGTC_1344 1488-0097 29.1 µM -0.430957869260995 0.331609608352049 no 2276 0.333249502309375 744 747966
SGTC_537 1334-0398 209 µM -0.432207522213247 0.331141307713786 no 2277 0.332795296347463 733 5846986
SGTC_584 0986-0246 15.4 µM -0.432855651753736 0.330898528617835 no 2278 0.332559820052459 749 53315 YDR232W HEM1
SGTC_1245 0418-0076 17.2 µM -0.433968999405008 0.330481652169119 no 2279 0.332155476473094 767 6790114
SGTC_1669 st015249 58.4 µM -0.435271843882595 0.329994088443863 no 2280 0.331682559818615 739 722793
SGTC_882 0843-0131 351 µM -0.436171372714823 0.329657625983721 no 2281 0.331356198245737 720 5425421
SGTC_2770 toltrazuril 17.5 µM -0.436591320487494 0.329500594633422 no 2282 0.33120387917447 726 68591 Kills coccidiodes.
SGTC_612 0302-0167 22.4 µM -0.436891958307573 0.32938819539475 no 2283 0.33109485211334 734 235821
SGTC_2662 daunorubicin 22.37 µM -0.437816052212668 0.329042801640794 no 2284 0.330759816823049 725 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2236 dapsone 200 µM -0.43827863472179 0.328869959370377 no 2285 0.330592155893881 731 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_378 3970-0959 8.33 µM -0.438547286690259 0.328769595334047 no 2286 0.330494799807865 756 6615653
SGTC_1086 cerivastatin 2.18 µM -0.439064041920995 0.328576578649001 no 2287 0.330307566481588 716 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3227 9130768 49.47 µM -0.439270519902182 0.328499468467913 no 2288 0.330232766226658 744 17720899
SGTC_1698 5-fluorocytosine 1.055 µM -0.439475661065129 0.328422864760694 no 2289 0.330158456975789 738 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2264 7948757 110.76 µM -0.440091271667465 0.328193027073512 no 2290 0.329935501669755 734 2971411
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.440789446392987 0.327932442834343 no 2291 0.329682717260018 726 803109
SGTC_1969 st069479 40.1 µM -0.440912727405907 0.327886438565524 no 2292 0.329638089636296 751 3895485
SGTC_159 3970-0959 50 µM -0.441009402743438 0.327850364454182 no 2293 0.329603094941774 719 6615653
SGTC_2147 5545932 89.7195 µM -0.441775650060015 0.327564498417103 no 2294 0.329325780300358 759 797404
SGTC_427 1354-0053 47.3 µM -0.442653340982628 0.327237179976649 no 2295 0.329008248136005 758 6813657
SGTC_547 1120-0019 610 nM -0.44420391700629 0.326659246280542 no 2296 0.328447580275683 737 3676939
SGTC_1091 telmisartan 47.6 µM -0.44479292418366 0.326439819257888 no 2297 0.328234704155421 763 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1137 ixabepilone 100 µM -0.446134423705938 0.325940285132667 no 2298 0.327750074123993 719 154225 A novel microtubule stabilizer.
SGTC_2057 5236571 38.335 µM -0.44666964773625 0.325741070873651 no 2299 0.327556800007107 735 54684039 YBR257W POP4
SGTC_3188 9110789 49.47 µM -0.447264499140305 0.325519721247542 no 2300 0.327342048129103 743 849217
SGTC_801 0866-0028 10.1 µM -0.449986863854344 0.324507490551386 no 2301 0.32635995623661 739 6849771
SGTC_2185 6113692 200 µM -0.450712258529973 0.324237992235914 no 2302 0.326098473053371 742 874150
SGTC_1202 1988-0068 29.6 µM -0.452735690197306 0.32348673466637 no 2303 0.325369538282321 732 2850480
SGTC_1913 st060213 96.1 µM -0.452864916490763 0.323438780057698 no 2304 0.325323007573971 758 688959
SGTC_120 rhodamine 6G 52.259 µM -0.454634189346918 0.322782515498791 no 2305 0.324686216918477 768 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3264 9137442 49.47 µM -0.455338054883658 0.322521588592737 no 2306 0.324433026308614 750 17015726
SGTC_932 2857-0803 154 µM -0.457155883684583 0.32184811379182 no 2307 0.323779502600766 749 674898
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.457193282185263 0.321834264412621 no 2308 0.323766063239865 709 2724 A muscle relaxant with antifungal properties.
SGTC_3186 9110464 49.47 µM -0.457949730404922 0.321554190342719 no 2309 0.323494278680879 735 17018021
SGTC_3193 9111931 49.47 µM -0.459159472650326 0.321106495484365 no 2310 0.323059825644222 756 17087244
SGTC_1891 st059073 26.2 µM -0.461813570295538 0.320125192668451 no 2311 0.322107509253069 763 688754
SGTC_3253 9135987 49.47 µM -0.462892428530673 0.319726663970316 no 2312 0.321720737454301 746 4182430
SGTC_2841 9004761 38.96 µM -0.463980561397448 0.319324919951342 no 2313 0.321330836292478 721 2991039
SGTC_179 1273-0063 6.77 µM -0.465479939499803 0.318771689588999 no 2314 0.320793899709134 779 3108139
SGTC_2629 bisabolol 100 µM -0.465606242618046 0.318725105536869 no 2315 0.320748686874452 777 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.466051393278078 0.318560944613642 no 2316 0.320589357116609 736 688662
SGTC_1938 st074717 56.4 µM -0.467687238275352 0.317957990141155 no 2317 0.320004134293845 742 17250979
SGTC_1916 st067606 49.2 µM -0.467690464831673 0.317956801344027 no 2318 0.320002980436607 718 19590279
SGTC_310 1273-0058 1.06 µM -0.468278258959806 0.317740264926222 no 2319 0.319792806903328 739 2734232
SGTC_1325 1431-0015 227 µM -0.468503765449965 0.317657207534682 no 2320 0.319712189436609 739 1103340
SGTC_2268 7933382 153.85 µM -0.468689785679681 0.317588700426144 no 2321 0.319645694525081 723 935025 YOR257W CDC31
SGTC_1010 4112-3296 15.2 µM -0.469468927870617 0.317301827596328 no 2322 0.319367244866223 747 704384
SGTC_94 0334-0113 514.748 µM -0.469851869424695 0.317160872321993 no 2323 0.319230426617386 743 6795178
SGTC_88 0180-0332 8.668 µM -0.47098127831115 0.316745307684812 no 2324 0.31882705219661 732 3101745
SGTC_1460 k062-0059 9.15 µM -0.472511985586711 0.316182454773099 no 2325 0.31828069436644 703 1373085
SGTC_552 k242-0005 476 µM -0.473021374687892 0.315995242795095 no 2326 0.318098964840883 782 4088318
SGTC_2074 5212007 75.395 µM -0.475126092964438 0.315222211987031 no 2327 0.317348550676764 738 758611
SGTC_523 1934-0222 13.7 µM -0.47590701898163 0.314935595234937 no 2328 0.317070310727941 773 1361595
SGTC_846 0335-0850 148 µM -0.476338730047785 0.314777195737832 no 2329 0.316916538648714 745 6819598
SGTC_2669 eugenol 100 µM -0.477751944076823 0.314258910551847 no 2330 0.316413384230076 743 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_250 brefeldin a 552.239 µM -0.477789088257432 0.314245293146276 no 2331 0.316400164158525 743 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2441 5730946 39.09 µM -0.478445613623945 0.314004646519742 no 2332 0.316166537425362 729 1774275
SGTC_2776 terbinafine 19.92 µM -0.478542434767066 0.313969163822953 no 2333 0.316132089506266 721 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_976 1348-1067 47.6 µM -0.48001960764957 0.313428027775685 no 2334 0.315606725391798 735 5310671 YGL099W LSG1
SGTC_602 3130-1533 38.1 µM -0.483532382969721 0.312142798586515 no 2335 0.314358886171567 761 720941
SGTC_2617 dihydrotanshinone i 20.83 µM -0.484677843754523 0.311724198393043 no 2336 0.313952442718803 745 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3128 9127691 49.47 µM -0.486362361997773 0.311109045429457 no 2337 0.313355135620207 766 41316314
SGTC_1093 fluphenazine 7.97 µM -0.486809867584738 0.310945713757742 no 2338 0.313196538451168 776 6602611 An atypical antipsychotic.
SGTC_2174 5790901 200 µM -0.488211171846658 0.31043450330677 no 2339 0.3127001360708 763 786020
SGTC_1983 st071813 46.9 µM -0.488457548595245 0.31034466029172 no 2340 0.312612893875591 749 11838595
SGTC_2316 5844804 197.44 µM -0.490158293060381 0.309724780750432 no 2341 0.312010945546657 753 776813
SGTC_3028 9087778 49.47 µM -0.491169564527827 0.309356453384282 no 2342 0.311653261664456 728 17217395
SGTC_395 anisomycin 6.25 µM -0.491192697647875 0.3093480300306 no 2343 0.311645081621729 767 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2388 9080168 200 µM -0.491510214495219 0.309232424247847 no 2344 0.311532814705533 768 15943073
SGTC_2839 9003951 25.97 µM -0.492209671738339 0.308977823126927 no 2345 0.311285563952325 765 2990634
SGTC_403 arphamenine a 50 µM -0.492361332950018 0.308922630829899 no 2346 0.311231964539094 772 5487158 An arginine aminopeptidase inhibitor.
SGTC_2239 6685329 187.64 µM -0.496119723008189 0.307556264435204 no 2347 0.30990497235962 740 805680
SGTC_2745 rifampicin 24.3 µM -0.49630927813193 0.307487421942861 no 2348 0.309838110618424 744 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1668 st014914 51.6 µM -0.49661955836725 0.307374749225932 no 2349 0.309728679107943 759 2839556
SGTC_1562 morin hydrate 59.1 µM -0.49688059388555 0.307279972924471 no 2350 0.309636628581285 770 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3285 9112818 20.8695 µM -0.497426602027135 0.307081770899903 no 2351 0.309444125050668 771 17017947 YPR165W RHO1
SGTC_2331 7980721 200 µM -0.498540536294127 0.306677585392183 no 2352 0.309051552633402 743 2981221
SGTC_337 1315-0038 354 µM -0.500296426059468 0.30604094675322 no 2353 0.3084331851235 770 1626437
SGTC_3217 9129673 49.47 µM -0.501129245398319 0.305739193308572 no 2354 0.308140082877171 770 17248312
SGTC_2803 7707263 71.43 µM -0.5023080193792 0.305312316358455 no 2355 0.307725434528468 747 2199229
SGTC_2096 5468907 200 µM -0.503573387673435 0.304854374945773 no 2356 0.307280598721132 747 759785
SGTC_1725 st036284 20.55 µM -0.504712928003039 0.304442232549605 no 2357 0.306880239776992 735 707914
SGTC_1821 st053465 65.6 µM -0.505300837196822 0.304229697953031 no 2358 0.306673777445029 758 675086
SGTC_1480 1070-0044 41.2 µM -0.505399154558252 0.304194161771204 no 2359 0.306639256274109 757 3124987
SGTC_520 3584-0023 682 µM -0.506039564405234 0.303962734991691 no 2360 0.306414437691804 740 1340790
SGTC_1400 3771-8998 51.5 µM -0.506520323775152 0.303789053177023 no 2361 0.306245712949515 744 670767
SGTC_710 3448-4187 58 µM -0.506563240338378 0.303773551052666 no 2362 0.306230653178478 743 3946412
SGTC_1673 st016611 27.3 µM -0.508109747792941 0.303215164424862 no 2363 0.305688189763084 792 5226799
SGTC_2855 9016525 58.44 µM -0.508949802476259 0.302912044237111 no 2364 0.30539370502818 750 43811474
SGTC_3027 9089541 49.47 µM -0.50926210796755 0.302799388433873 no 2365 0.305284257102182 760 9943819
SGTC_1049 3226-0134 66 µM -0.511028746477015 0.302162474706602 no 2366 0.304665463942269 756 5702385
SGTC_1786 berberine 21.6 µM -0.511680950672768 0.301927492205078 no 2367 0.304437160128222 755 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.511756494690871 0.301900279774193 no 2368 0.304410720896725 762 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2488 5268135 45.7 µM -0.511871719129786 0.301858775803107 no 2369 0.304370396103532 776 1270356 YLR208W SEC13
SGTC_542 3381-0244 89.3 µM -0.511936828825126 0.301835324352272 no 2370 0.304347610886682 789 1112843
SGTC_2175 5807670 165.306 µM -0.512665609414568 0.301572885361228 no 2371 0.304092625077607 754 241186
SGTC_1288 0973-0013 65.5 µM -0.512690566166041 0.301563900078409 no 2372 0.304083894893649 761 4315430
SGTC_981 1488-1094 54.9 µM -0.513763040526128 0.301177886536903 no 2373 0.30370883553638 757 3449522
SGTC_2726 cimetidine 79.27 µM -0.514251024495851 0.301002321165122 no 2374 0.30353824905315 780 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1186 1319-0216 26 µM -0.515351393284141 0.300606603283623 no 2375 0.30315374591442 765 4565136
SGTC_444 curcumin 90.4 µM -0.516427700328003 0.300219765940014 no 2376 0.302777861579608 759 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3299 9121982 43.1275 µM -0.516852116087111 0.30006728784625 no 2377 0.302629698048654 776 17594604 YPL160W CDC60
SGTC_1146 3579-1023 7 µM -0.517311801324262 0.299902178163791 no 2378 0.302469258605118 785 X1146
SGTC_730 1436-0052 41.2 µM -0.517599209870458 0.299798967697598 no 2379 0.302368966590825 737 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_190 3970-0790 3.722 µM -0.518252662145363 0.299564368182991 no 2380 0.302140998123862 757 2832352
SGTC_1989 st071868 50.2 µM -0.518737634341487 0.299390309437653 no 2381 0.301971856832031 767 16414057
SGTC_1674 st016616 23.6 µM -0.520528970799748 0.298747788499017 no 2382 0.301347470543106 756 625830
SGTC_336 4111-0029 111 µM -0.520708744965262 0.298683341283155 no 2383 0.301284840762384 779 3131175
SGTC_2261 9010538 184.68 µM -0.521033984212252 0.298566762375177 no 2384 0.301171548708693 814 6457250
SGTC_1736 st036774 51 µM -0.521762263119562 0.298305792829539 no 2385 0.30091793366578 789 1272247
SGTC_949 1165-0505 146 µM -0.524288221380589 0.2974014533993 no 2386 0.300039044014666 746 6244267
SGTC_2588 indole-3-carbinol 100 µM -0.524482820318279 0.297331835388618 no 2387 0.299971382869453 779 3712 Induces cell cycle arrest.
SGTC_68 0986-0284 82.829 µM -0.527153636266408 0.296377100981025 no 2388 0.299043451151387 751 423278 YIL048W NEO1
SGTC_1661 st013063 9.66 µM -0.527249344039172 0.296342914499582 no 2389 0.299010223238371 783 721395
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.529137332252144 0.295668901661536 no 2390 0.298355092797591 743 6708561
SGTC_1295 1013-0063 9.78 µM -0.529305578822344 0.295608871749201 no 2391 0.298296743088414 772 6826038
SGTC_2882 9058044 58.44 µM -0.529336255671006 0.295597926938132 no 2392 0.298286104589388 771 18076804
SGTC_1379 2144-0755 36.5 µM -0.532597071251922 0.294435605040126 no 2393 0.297156264970921 785 5392327
SGTC_1287 0971-0001 34.6 µM -0.532898835421684 0.294328147554549 no 2394 0.297051805715962 750 4665869
SGTC_202 3594-0513 34.79 µM -0.533782032672773 0.294013747284086 no 2395 0.296746173033342 773 708429
SGTC_1222 0366-0074 1.18 µM -0.534700595256461 0.293686922483837 no 2396 0.296428454908422 778 286520
SGTC_2866 9034245 58.44 µM -0.534739532238048 0.293673072411582 no 2397 0.296414990589065 760 6462273
SGTC_572 0960-0087 17.7 µM -0.534847390909073 0.293634708140531 no 2398 0.296377694770717 784 6796365
SGTC_2295 7971645 200 µM -0.535800446738896 0.293295816401118 no 2399 0.296048236706152 760 2978226 YKL099C UTP11
SGTC_1251 0490-5699 265 µM -0.536736507555346 0.292963144388528 no 2400 0.295724817300581 789 3883818
SGTC_1376 2910-0861 41.3 µM -0.538228577965301 0.292433231235781 no 2401 0.295209626339446 791 1112859
SGTC_2592 piperlongumine 83.33 µM -0.538823927765624 0.292221915460502 no 2402 0.295004175798913 780 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1096 rimcazole 32.2 µM -0.539923576355234 0.291831788812664 no 2403 0.294624869007893 770 18528119 A dopamine reuptake inhibitor.
SGTC_2747 doxorubicin 7.63 µM -0.54012958351092 0.291758729839127 no 2404 0.294553835051871 744 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3207 9114163 49.47 µM -0.541177459871987 0.291387239935044 no 2405 0.29419263599841 823 849233
SGTC_2173 5763948 167 µM -0.541875424545789 0.291139922168065 no 2406 0.293952163796203 759 2867177
SGTC_2680 butyl paraben 22.24 µM -0.542327929731905 0.290979633250484 no 2407 0.29379630918851 796 7184 An antifungal and steroid mimetic.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.5426403829459 0.290868978396676 no 2408 0.29368871445766 790 2346 DNA damaging agent; causes G2/M arrest.
SGTC_712 r015-0009 80.6 µM -0.542644329339759 0.290867580912791 no 2409 0.293687355615046 756 6813872 YLR060W FRS1
SGTC_1020 4335-0961 93.3 µM -0.542941732818902 0.290762274411894 no 2410 0.293584960494619 788 669075
SGTC_3052 9092717 49.47 µM -0.543163632414231 0.290683714417435 no 2411 0.293508571902778 798 25237534
SGTC_42 0133-0086 60.653 µM -0.543351590358696 0.290617178687447 no 2412 0.29344387487333 802 162923 Model of phenazepam hydroxylation.
SGTC_2466 5983409 37.09 µM -0.544651164864167 0.290157333924489 no 2413 0.292996729011493 764 2879657
SGTC_2940 9060638 45.86 µM -0.54484891978076 0.29008738971811 no 2414 0.292928715007139 756 4027022
SGTC_910 3454-3003 490 µM -0.545908192802244 0.289712868594956 no 2415 0.29256452319978 792 820824
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.546980518442299 0.289333963819758 no 2416 0.292196058180239 764 688664
SGTC_121 0557-0495 61.343 µM -0.54804581999318 0.28895777173615 no 2417 0.29183022066665 794 3104427
SGTC_1570 verbenone 133 µM -0.548342290355536 0.288853119509775 no 2418 0.291728447105342 787 29025 A natural terpanoid with antifungal properties.
SGTC_1922 5578187 25 µM -0.548449324087264 0.28881534163989 no 2419 0.291691708191339 757 1350412
SGTC_1594 piperine 70.1 µM -0.548534564245022 0.288785257539716 no 2420 0.291662451379845 779 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1429 4049-0205 9.46 µM -0.549139575575964 0.28857177123153 no 2421 0.291454833852086 765 22774478
SGTC_1886 st057356 49.9 µM -0.550101516729721 0.288232490656298 no 2422 0.291124873221669 754 24207747
SGTC_3278 9139605 49.47 µM -0.55038540184757 0.288132399184317 no 2423 0.291027529603522 794 7958859
SGTC_2682 pyrogallin 40.03 µM -0.550537306572507 0.288078847750396 no 2424 0.290975448034241 774 822798 An ATP competetive kinase inhibitor.
SGTC_2475 5812728 15.03 µM -0.551544994733287 0.287723723365756 no 2425 0.290630065603177 773 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_958 1222-0007 33 µM -0.551901143612366 0.287598260662822 no 2426 0.290508042410121 796 7312461
SGTC_2088 5278280 127.392 µM -0.552063488611801 0.287541078997675 no 2427 0.290452427967644 779 791502
SGTC_711 k292-0785 179 µM -0.552462115098741 0.287400696333353 no 2428 0.290315891844705 779 4146315
SGTC_1397 3532-0190 20.1 µM -0.555275195392069 0.286410948123948 no 2429 0.289353221197412 761 5322280
SGTC_902 1120-0002 2.07 µM -0.556206944762618 0.286083480406533 no 2430 0.289034696111015 781 3280475
SGTC_2809 7964133 12.99 µM -0.556267363420634 0.286062252126921 no 2431 0.28901404726271 792 1253665
SGTC_317 4495-0002 170 µM -0.558180306937938 0.285390520909213 no 2432 0.288360633472858 777 15991618
SGTC_1867 st057372 64 µM -0.558956434301591 0.285118197719361 no 2433 0.288095726485749 754 688837
SGTC_3005 9076496 71.4286 µM -0.559849447810825 0.28480501551379 no 2434 0.287791066203418 787 21368410
SGTC_3094 9117742 49.47 µM -0.560982087093655 0.284408032205231 no 2435 0.287404874320958 818 17149698
SGTC_123 0083-0120 66.675 µM -0.562269930221911 0.283956972347896 no 2436 0.286966061196824 782 16001701
SGTC_1169 aniline yellow 25.8 µM -0.56235076417211 0.283928672129987 no 2437 0.286938528836378 787 6051 A DNA damaging agent.
SGTC_3119 9125183 49.47 µM -0.564682452956276 0.283112922208265 no 2438 0.286144885698083 757 22695334
SGTC_272 doxorubicin 8.13 µM -0.564941260665463 0.28302244676765 no 2439 0.286056858961029 767 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2420 aureobasidin a 50 nM -0.565005619235586 0.282999950095177 no 2440 0.28603497105873 771 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_514 4466-0038 2.65 nM -0.565946163593335 0.282671278831348 no 2441 0.285715189299258 784 5722064
SGTC_1383 3049-0032 20.7 µM -0.566686640497745 0.282412649849067 no 2442 0.28546354948371 798 712864
SGTC_1135 dihydrocapsaicin 536.708 nM -0.567216514083554 0.282227648921116 no 2443 0.285283544799469 790 107982 A Capsaicinoid.
SGTC_857 0438-0306 1.35 µM -0.569067433308787 0.281581874072425 no 2444 0.284655189109042 770 4686136
SGTC_3071 9117417 49.47 µM -0.569638311468433 0.281382841931392 no 2445 0.284461519063053 779 45595590 YGL055W OLE1
SGTC_44 0929-0055 61.211 µM -0.57108822412837 0.280877646806872 no 2446 0.283969920291829 754 1379590
SGTC_468 gf-109203x 121 µM -0.573518927862442 0.280031698243366 no 2447 0.283146693519213 762 2396 A protein kinase C inhibitor.
SGTC_1868 st057644 42.7 µM -0.573668253242558 0.279979769394188 no 2448 0.283096157600415 787 688665
SGTC_1119 parthenolide 318.541 nM -0.574927899590095 0.279541905280741 no 2449 0.282670030113656 817 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_668 1682-0499 62.6 µM -0.575503953004405 0.279341774913613 no 2450 0.282475258985751 805 682214
SGTC_1952 st077036 64.1 µM -0.575777932538031 0.279246614380809 no 2451 0.282382645605533 790 2937007
SGTC_354 2783-3500 4.88 µM -0.576453187618548 0.279012147238589 no 2452 0.28215445131869 793 6740761
SGTC_1176 0848-0131 83.3 µM -0.577024257536388 0.278813930809444 no 2453 0.281961534456376 799 6769040
SGTC_1475 4092-1048 11.7 µM -0.578069316672323 0.278451371889689 no 2454 0.281608660812664 794 2881759
SGTC_773 4358-1457 44.6 µM -0.57822365540586 0.27839784713585 no 2455 0.281556565001698 825 1186886
SGTC_641 4092-0595 30 µM -0.578433211747839 0.278325180912968 no 2456 0.281485838368037 794 786260
SGTC_608 k048-0125 159 µM -0.579778726671388 0.277858827549535 no 2457 0.281031922614271 795 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1843 st055809 45.5 µM -0.581118589765983 0.277394812488884 no 2458 0.28058026526555 790 16413835
SGTC_334 1502-1024 68.5 µM -0.582768592779407 0.27682391227503 no 2459 0.280024545241659 799 3296216
SGTC_216 k038-0035 28.382 µM -0.583146401725626 0.276693271588596 no 2460 0.279897374529302 784 4444231 YPR107C YTH1
SGTC_1147 3809-1045 12.3 µM -0.583253008678023 0.276656413963579 no 2461 0.279861495634019 781 325925
SGTC_286 k060-0067 22.9 µM -0.583663240899499 0.276514605273052 no 2462 0.279723451538939 775 5985051
SGTC_973 1325-0077 65.9 µM -0.58405432463726 0.276379449002394 no 2463 0.279591881723895 793 2835149
SGTC_323 4013-0906 34.3 µM -0.584308520102286 0.276291617903387 no 2464 0.279506380472134 773 2910086
SGTC_2796 7949634 45.45 µM -0.585100386725675 0.276018095342186 no 2465 0.279240109422515 789 2971588
SGTC_251 melphalan 456.522 µM -0.586459369225756 0.27554899262275 no 2466 0.278783428968697 793 460612 A DNA alkylator.
SGTC_3205 9113483 49.47 µM -0.587857187689874 0.275066893657209 no 2467 0.278314077423099 801 17018033
SGTC_1071 trifluoperazine 6.31 µM -0.588155681994509 0.274963998669706 no 2468 0.278213900632271 818 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1218 1348-1416 30.7 µM -0.588371087024604 0.27488975745136 no 2469 0.278141620110998 789 6787668
SGTC_955 1216-0110 33 µM -0.590197080705541 0.274260809945674 no 2470 0.277529264540767 799 3619719
SGTC_1073 triclabendazole 3.09 µM -0.59190633864094 0.273672715672268 no 2471 0.276956654501527 790 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_815 1582-0027 36.9 µM -0.593113336818809 0.273257807100993 no 2472 0.276552652761495 804 3128206
SGTC_157 1348-1695 65.819 µM -0.594997716415361 0.272610670627109 no 2473 0.275922498716153 776 5380510
SGTC_3282 9108498 15.4605 µM -0.595348006425934 0.272490457408256 no 2474 0.27580543627131 802 16459645
SGTC_1834 st055981 52.8 µM -0.595349645888503 0.272489894836142 no 2475 0.275804888441255 797 471719 YDL150W RPC53
SGTC_2205 7238770 200 µM -0.597478891221293 0.271759743743145 no 2476 0.275093848042876 790 279867
SGTC_56 0957-0365 83.25 µM -0.600553069199132 0.270707281354119 no 2477 0.274068852070408 779 6752360
SGTC_2807 7945238 51.95 µM -0.601193644052989 0.270488233395259 no 2478 0.273855508677064 798 17148797
SGTC_694 1315-0438 43.2 µM -0.601504779658586 0.270381870893655 no 2479 0.273751914629221 796 6793154
SGTC_1557 sumaresinolic acid 42.3 µM -0.60152395109985 0.270375317771283 no 2480 0.27374553204262 783 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1707 st032323 6.317 µM -0.601729559808052 0.270305042234304 no 2481 0.273677085093694 794 3132057 YMR211W DML1
SGTC_1494 4358-1428 177 µM -0.603416142936511 0.26972892549361 no 2482 0.27311594291324 804 1564571
SGTC_3039 9090270 49.47 µM -0.604500425675506 0.269358872447844 no 2483 0.272755493144808 785 17173750
SGTC_2129 girgensonine 121.053 µM -0.607238853834985 0.268425413601164 no 2484 0.271846205368934 805 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1778 st046819 58.9 µM -0.607261616580054 0.26841766119627 no 2485 0.271838653385358 809 671715
SGTC_454 lyso-paf C-16 6.67 µM -0.607676053505975 0.268276534338416 no 2486 0.271701174126174 818 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_900 1112-0045 141 µM -0.608530131090435 0.267985815854785 no 2487 0.27141796408985 794 56211 YIL048W NEO1
SGTC_2512 diallyl trisulfide 49.23 µM -0.609332287842819 0.267712915173389 no 2488 0.271152104880205 820 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2215 7188065 200 µM -0.60997189077395 0.26749541710862 no 2489 0.270940214051141 809 940217
SGTC_1765 st044815 90.4 µM -0.610423140683549 0.267342022436231 no 2490 0.270790771466972 816 645695
SGTC_1188 1403-0014 4.57 µM -0.610460551894394 0.26732930712873 no 2491 0.270778383665234 792 9614867
SGTC_580 1123-0028 41 µM -0.611144653499842 0.267096848761751 no 2492 0.270551910152297 813 1677248 YPR107C YTH1
SGTC_480 am 92016 50 µM -0.612434933949526 0.266658688196574 no 2493 0.270125017353887 844 2129 K+ channel blocker.
SGTC_3144 9087057 49.47 µM -0.612477508549648 0.266644236673989 no 2494 0.270110937175932 820 17249618
SGTC_517 1365-0151 113 µM -0.612811496648073 0.266530881490142 no 2495 0.270000494106494 796 768657
SGTC_2774 tamoxifen 10.92 µM -0.612994860217877 0.266468658466205 no 2496 0.269939869114632 808 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2760 etidronate 98.04 µM -0.613577453524665 0.266271008661331 no 2497 0.269747293118908 806 3305 A chelator and antioxidant.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.617952049908602 0.264789263466084 no 2498 0.268303473496438 810 2374 Ca(2+)-ATPase inhibitor.
SGTC_2208 7283366 200 µM -0.618756646355526 0.264517191025621 no 2499 0.268038343238725 813 898663
SGTC_1645 Cervolide 78 µM -0.61896200002915 0.264447773944862 no 2500 0.267970696322821 798 23173 A fragrance.
SGTC_1550 gossypolone 36.6 µM -0.619307027133025 0.264331162995273 no 2501 0.267857058014942 796 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_950 1165-0508 94.1 µM -0.619718065217416 0.264192276084292 no 2502 0.267721709988071 799 6148369
SGTC_826 1683-5028 118 µM -0.620323246801222 0.263987857103024 no 2503 0.267522496470531 804 722377
SGTC_2345 9052315 157.45 µM -0.621468919605564 0.263601091198497 no 2504 0.267145568991518 797 6469265
SGTC_2729 fluphenazine 10.66 µM -0.622234004305528 0.263342968541058 no 2505 0.266894004753099 817 3372 An atypical antipsychotic.
SGTC_546 peri-Naphthalide 147 µM -0.622967051694555 0.263095775689398 no 2506 0.266653086881194 791 223824 A penicillin ester.
SGTC_2919 7978188 46.38 µM -0.624786389702876 0.262482784622739 no 2507 0.266055632289677 781 2980291
SGTC_2782 7736369 71.43 µM -0.624837313363177 0.262465637396289 no 2508 0.26603891916706 804 2950836 YOL077C BRX1
SGTC_2783 7738165 71.43 µM -0.627128876441944 0.261694606748757 no 2509 0.265287379984452 817 17201110
SGTC_952 1185-0122 232 µM -0.627384387094198 0.261608708445969 no 2510 0.265203649750975 804 678600
SGTC_115 0527-0192 112.043 µM -0.631079345640471 0.260368146488578 no 2511 0.263994322652683 830 4233931
SGTC_1350 1495-0454 146 µM -0.631242068767544 0.260313582845663 no 2512 0.263941129499069 802 1069057
SGTC_2524 avocatin b 10.57 µM -0.631799180588951 0.260126819046164 no 2513 0.263759054572707 800 6710748
SGTC_3283 9109332 35.8195 µM -0.632190349308725 0.259995726594977 no 2514 0.263631251351487 791 17027281
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.634073028720998 0.259365260789595 no 2515 0.263016581823232 801 6708784 An antioxidant flavonoid
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.634441533659234 0.259241949501993 no 2516 0.262896355688384 793 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2686 alizarin 95.37 µM -0.635185619945904 0.25899305136842 no 2517 0.262653680392418 786 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_536 3852-0578 10.6 µM -0.635474245478474 0.258896538914358 no 2518 0.262559579313151 807 2869208
SGTC_822 1487-0950 154 µM -0.637548893463488 0.258203352781276 no 2519 0.261883686405015 789 1958375
SGTC_1346 1488-2224 62.4 µM -0.638416243707866 0.257913837195407 no 2520 0.261601379883245 807 3722427
SGTC_1473 k844-0725 134 µM -0.63916722538706 0.257663300755394 no 2521 0.261357075414759 819 54682906
SGTC_1846 st056244 14.8 µM -0.641254496783998 0.256967626379484 no 2522 0.260678673893686 814 5393182
SGTC_2447 5741742 33.78 µM -0.641418841824696 0.256912892743556 no 2523 0.26062529725199 804 1776504
SGTC_2923 7992654 58.14 µM -0.642896922704808 0.256420903968157 no 2524 0.260145493167577 797 2985126
SGTC_2921 7974240 10.71 µM -0.644457409969722 0.255902018946815 no 2525 0.259639433460291 809 2979074 YDR527W RBA50
SGTC_1454 4239-0054 42.6 µM -0.645408806941638 0.255585934509464 no 2526 0.259331148827458 814 1340767
SGTC_729 4092-0585 94.1 µM -0.645732879538889 0.255478313830507 no 2527 0.259226181601919 803 2169061
SGTC_2108 5365811 200 µM -0.646118483251833 0.255350290249057 no 2528 0.259101313042185 796 780283
SGTC_3025 9087895 49.47 µM -0.646377021333183 0.255264472276677 no 2529 0.25901760907398 817 17173641
SGTC_2502 avocadyne acetate 18.59 µM -0.648797275811256 0.254461835704619 no 2530 0.258234709259119 795 3952079
SGTC_103 0844-0104 51.839 µM -0.64892952933196 0.254418014193581 no 2531 0.258191963486656 820 5375804
SGTC_2061 5245884 80.95 µM -0.649510233860944 0.254225647608186 no 2532 0.258004316906118 827 573863
SGTC_3308 9128332 17.569 µM -0.650242345914176 0.253983233870415 no 2533 0.257767845939366 801 17332805 YDL196W YDL196W
SGTC_236 1509-0011 5.31 µM -0.650471077930247 0.253907522000716 no 2534 0.257693988951866 843 3107280
SGTC_1579 chlormadinone acetate 49.4 µM -0.650802105368797 0.253797970622495 no 2535 0.257587120490539 824 45114258 A steroidal progestin.
SGTC_2600 tangeritin 87.95 µM -0.653445295959027 0.252924114800105 no 2536 0.256734622661703 824 68077 A bioactive flavone.
SGTC_7 0192-1582 4.227 µM -0.653518514426153 0.25289993086338 no 2537 0.256711028723134 848 252616
SGTC_376 3970-0862 59.1 µM -0.654494174385745 0.252577788217273 no 2538 0.256396739574254 834 3135186
SGTC_2536 dehydroabietamide 32.04 µM -0.65531852218633 0.252305774280201 no 2539 0.256131348943994 814 3983547
SGTC_2360 9040895 200 µM -0.656263021393036 0.251994303370913 no 2540 0.25582745294799 804 4914414
SGTC_2315 7733312 200 µM -0.656710156106223 0.25184692093821 no 2541 0.255683651421235 815 726316
SGTC_746 1095-0025 46.6 µM -0.657504563807092 0.251585184304886 no 2542 0.255428268717965 828 6749286
SGTC_2808 7946468 45.46 µM -0.658337910357346 0.251310772851877 no 2543 0.255160511449438 829 2970879
SGTC_946 3434-1334 87.4 µM -0.658532598560871 0.251246687071624 no 2544 0.255097978582075 811 4047976
SGTC_1803 st050068 52.4 µM -0.662102920053738 0.250072973483153 no 2545 0.253952632276708 833 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_150 3970-0969 77.2 µM -0.66219399397144 0.250043071781949 no 2546 0.253923451427756 841 6615640
SGTC_2513 baicalein 25.65 µM -0.662478979037062 0.249949516763923 no 2547 0.253832151186342 829 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3318 9139014 38.6185 µM -0.662818808433618 0.249837981713874 no 2548 0.253723303078674 842 16643984
SGTC_346 4513-0042 7.16 µM -0.662862866854286 0.249823523280877 no 2549 0.25370919286408 812 2827372
SGTC_3195 9113082 49.47 µM -0.663123213244365 0.249738095768311 no 2550 0.253625822358767 817 17018038
SGTC_1421 4029-0249 71.4 µM -0.666327745998627 0.248687863591034 no 2551 0.252600817308575 835 2894095
SGTC_2322 7413319 38.22 µM -0.666523567390136 0.248623762740922 no 2552 0.252538252505804 817 1840400
SGTC_119 0121-0043 24.815 µM -0.667703536969857 0.2482376937936 no 2553 0.252161425909049 836 1092378
SGTC_2156 5649887 115 µM -0.667704646640672 0.248237330875906 no 2554 0.252161071672192 827 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2999 9069765 71.4286 µM -0.667874951761583 0.248181635962353 no 2555 0.252106708795056 802 2097066
SGTC_1680 diphenhydramine 100 µM -0.667922536786598 0.248166075414529 no 2556 0.252091520345952 816 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_794 k038-0031 316 µM -0.669872376983213 0.247528915379993 no 2557 0.251469575029567 830 6624242
SGTC_985 1493-0307 8.71 µM -0.670047704174847 0.247471665606307 no 2558 0.25141369024612 833 3278274
SGTC_2183 6420625 130.508 µM -0.67054315990962 0.247309922176259 no 2559 0.251255801366293 828 2897619
SGTC_877 0771-0151 33.1 µM -0.670768122936389 0.247236500791131 no 2560 0.251184128801595 817 6166523
SGTC_825 1988-2224 89.6 µM -0.672291616602114 0.24673958367996 no 2561 0.250699032868582 822 1180859
SGTC_285 1486-1325 46 µM -0.672988317269533 0.246512519517949 no 2562 0.250477361701774 829 22310230
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.674109287107615 0.246147415404472 no 2563 0.250120917767571 816 16623 A steroid.
SGTC_2000 st075254 36.4 µM -0.674121788569916 0.246143345266761 no 2564 0.250116944093167 804 17234175
SGTC_2730 imipramine 71.33 µM -0.67438141809222 0.246058825081812 no 2565 0.250034426662353 810 3696 A tricyclic antidepressant.
SGTC_913 3487-1245 167 µM -0.67467875441629 0.245962048895757 no 2566 0.249939942715212 812 4016153
SGTC_2451 5856223 45.7 µM -0.674858153112595 0.245903668595618 no 2567 0.249882944730254 826 2179896
SGTC_731 3966-0296 387 µM -0.675563555791179 0.24567418710202 no 2568 0.249658893345543 803 660956
SGTC_2570 licareol 100 µM -0.677426897391117 0.245068558616724 no 2569 0.249067568685667 829 443158
SGTC_114 0364-0001 490.298 µM -0.677760408924815 0.244960244561806 no 2570 0.248961808690179 829 4003655
SGTC_1860 st056228 74.6 µM -0.679322816120299 0.24445316701171 no 2571 0.248466671420351 850 688679
SGTC_2237 6667747 47.222 µM -0.683081945802719 0.243235466398814 no 2572 0.247277531520602 833 729940 YDL015C TSC13
SGTC_1398 3558-0053 112 µM -0.683770842095186 0.243012667221642 no 2573 0.247059940689187 812 4532369
SGTC_793 0488-0545 106 µM -0.684025282734776 0.242930405305626 no 2574 0.24697960043836 838 292548
SGTC_3290 9121031 71.43 µM -0.685547632918939 0.242438536841357 no 2575 0.246499206840881 828 17014854
SGTC_1097 itavastatin 7.23 µM -0.685669909921936 0.242399052794011 no 2576 0.246460642780671 824 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_632 0781-2353 4.65 µM -0.687152405763919 0.241920622445436 no 2577 0.245993346446162 839 6811515 YHR007C ERG11
SGTC_3296 9122258 64.045 µM -0.688413842392345 0.24151393594691 no 2578 0.245596104651165 827 4730474
SGTC_3142 9086498 49.47 µM -0.689946473866004 0.241020316394556 no 2579 0.245113924296109 825 25236367
SGTC_1622 st003707 19.4 µM -0.691112697172495 0.240645074976157 no 2580 0.24474736080359 805 10140899
SGTC_2288 7946289 167.31 µM -0.692720554886216 0.240128256130956 no 2581 0.244242468542927 840 1246052
SGTC_3183 9108214 49.47 µM -0.693085651364045 0.240010986348441 no 2582 0.244127900861764 811 4974831
SGTC_1863 st057641 20.1 µM -0.693523207434443 0.239870483535855 no 2583 0.243990633467677 844 3921635
SGTC_1332 1480-0653 17.5 µM -0.69392539339607 0.239741377934539 no 2584 0.243864498900115 824 5749438
SGTC_1132 3456-3614 2.5 µM -0.694198565066112 0.239653708801952 no 2585 0.24377884618921 834 3125502
SGTC_2071 5230951 39.92 µM -0.695479125759058 0.239242971120331 no 2586 0.243377544204375 847 1799272
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.695593810733673 0.239206204883181 no 2587 0.243341621662871 822 66535 A nucleotide analog.
SGTC_2589 lobaric acid 100 µM -0.695694971407143 0.239173776891668 no 2588 0.243309937689333 842 73157 A novel microtubule depolymerizer.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.696386346274303 0.238952214598778 no 2589 0.243093455704441 831 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1013 4112-3890 241 µM -0.696624244103143 0.238876002340584 no 2590 0.243018989682249 841 705171
SGTC_3049 9092223 49.47 µM -0.699110037496373 0.238080456503471 no 2591 0.242241633057082 829 8623917
SGTC_2158 5657123 3.6195 µM -0.699614470331989 0.237919196747992 no 2592 0.242084051620765 853 2858827
SGTC_289 k017-0060 526 µM -0.699731065694941 0.237881931448914 no 2593 0.242047635921519 845 5512909
SGTC_2612 dictamnine 15.46 µM -0.700702705547696 0.237571508014703 no 2594 0.241744283627321 824 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.700802735187778 0.237539562766438 no 2595 0.241713065440937 836 4330530
SGTC_3003 9075612 71.4286 µM -0.702637242665829 0.236954116737383 no 2596 0.241140923422628 850 6501993
SGTC_2369 9071472 200 µM -0.703538187205464 0.236666889141811 no 2597 0.240860208685391 848 17296037
SGTC_2693 st077581 40.7 µM -0.703609901793271 0.236644034248032 no 2598 0.240837871619823 834 25238761
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.705341261079006 0.236092631872206 no 2599 0.240298944377848 829 641818 YHR062C RPP1
SGTC_3332 9141069 11.198 µM -0.707543923810038 0.235392153302092 no 2600 0.23961426337735 837 17332883
SGTC_1694 st024011 44.9 µM -0.709402798017585 0.234801898065219 no 2601 0.239037275958284 851 2787533
SGTC_3319 9138450 16.7555 µM -0.71133357515985 0.234189678455448 no 2602 0.238438775210261 835 2029690
SGTC_2302 7771753 200 µM -0.713307536868208 0.233564680434519 no 2603 0.237827737350185 838 2203047
SGTC_623 k072-0108 16.9 µM -0.714447749492434 0.233204086887206 no 2604 0.237475177346146 839 5382803
SGTC_2463 5473429 200 µM -0.715221391049019 0.232959597930282 no 2605 0.237236126593319 830 5399405
SGTC_477 mead ethanolamide 10 µM -0.716746374784301 0.23247808430523 no 2606 0.236765302766714 801 16061185
SGTC_1217 1183-1422 255 µM -0.717516285413599 0.23223519542852 no 2607 0.236527795736305 835 2849664
SGTC_2687 chenodiol 100 µM -0.718046373739214 0.232068047019733 no 2608 0.236364346887942 818 5702181 A cholesterol synthesis inhibitor.
SGTC_1892 st058411 7.36 µM -0.719210326870624 0.2317012623003 no 2609 0.236005668744877 849 3934738
SGTC_1094 duloxetine 25.4 µM -0.71936476718952 0.231652619377879 no 2610 0.235958099715082 825 60834 A selective serotonin reuptake inhibitor.
SGTC_2805 7950783 58.44 µM -0.720582611176082 0.231269243526588 no 2611 0.235583177817678 841 1178958 YDL195W SEC31
SGTC_2769 toremifene 3.73 µM -0.720659346641504 0.231245099151343 no 2612 0.235559565272126 847 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_596 1155-0152 116 µM -0.721586851800185 0.230953376203273 no 2613 0.23527426262292 838 280313
SGTC_1512 0259-0544 12.2 µM -0.722200503858232 0.230760480685816 no 2614 0.235085606801347 831 18476
SGTC_1403 3909-7815 62.9 µM -0.722301091941103 0.230728870393176 no 2615 0.235054690853906 835 6615483
SGTC_2947 9072639 7.68 µM -0.722372794988559 0.230706338839669 no 2616 0.235032654150799 877 16488146
SGTC_2587 piperic acid 92.2 µM -0.722993577684004 0.23051131904908 no 2617 0.234841914949055 829 5370536
SGTC_1463 k081-0032 34.1 µM -0.723753506450632 0.230272711800216 no 2618 0.234608538802353 824 977755
SGTC_1486 3970-0793 4.53 µM -0.724606565931591 0.23000502741642 no 2619 0.234346714843143 860 2844330
SGTC_733 4069-0007 56.1 µM -0.724621069950443 0.230000477658009 no 2620 0.234342264618184 849 5717425 YNL287W SEC21
SGTC_423 5-fluorouracil 457 µM -0.724759656668512 0.22995700699978 no 2621 0.234299744826339 846 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_318 1488-0629 67.2 µM -0.725199242251146 0.2298191521059 no 2622 0.234164903828927 861 3662576
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.727264872871512 0.229171986270212 no 2623 0.23353185615979 833 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2072 5231554 129 µM -0.727509962201326 0.229095267222453 no 2624 0.233456807402945 843 789545
SGTC_2935 9038016 29.96 µM -0.728072753371065 0.228919154141041 no 2625 0.233284525868713 851 6463195
SGTC_660 4031-1742 102 µM -0.730798155568002 0.228067375304407 no 2626 0.232451225159673 835 6738706
SGTC_924 2046-0044 21.3 µM -0.732576677903906 0.227512490397955 no 2627 0.231908329949715 838 3623589
SGTC_1805 st050013 60.3 µM -0.733036184928019 0.227369251531478 no 2628 0.231768179980513 841 4037144
SGTC_1864 st057645 30.4 µM -0.736520396853777 0.226284797472654 no 2629 0.2307070296352 847 688666
SGTC_1026 k007-1105 30.6 µM -0.738390063028214 0.225704074360307 no 2630 0.230138725644847 837 7066794
SGTC_583 1488-1091 88.9 µM -0.738575486755581 0.225646527265603 no 2631 0.230082406941647 870 4303273
SGTC_497 capsazepine 133 µM -0.739903188020337 0.225234711785398 no 2632 0.229679369934046 849 2733484 A calcium channel blocker.
SGTC_2955 9076254 12.21 µM -0.740318120406219 0.225106098824328 no 2633 0.229553494203511 837 16459619
SGTC_3030 9087619 49.47 µM -0.740407041093921 0.225078542271756 no 2634 0.229526523858912 835 25236973
SGTC_3351 9150312 21.596 µM -0.74137170757901 0.224779714660999 no 2635 0.229234047058968 852 4904905
SGTC_683 panaxydol 45 µM -0.741604467152152 0.224707645738423 no 2636 0.22916350809625 815 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3213 9129884 49.47 µM -0.742528246024816 0.224421747018882 no 2637 0.228883672313838 854 17190742
SGTC_298 1391-0729 10 µM -0.74356191649517 0.224102083022823 no 2638 0.228570775095502 852 3237558
SGTC_450 aminopyrene 156 nM -0.74415664872591 0.223918278542441 no 2639 0.22839085561578 849 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3212 9128307 49.47 µM -0.74445924623802 0.223824792408453 no 2640 0.228299343819564 852 27243542
SGTC_400 oxethazaine 37.5 µM -0.744710781829807 0.223747098511769 no 2641 0.228223289901145 854 4621 A local anesthetic.
SGTC_2391 6285546 200 µM -0.744753724187534 0.223733836079801 no 2642 0.228210307338776 847 846083
SGTC_755 1995-0008 37.3 µM -0.744836640320434 0.223708229305417 no 2643 0.228185240866561 826 689533
SGTC_2752 diclazuril 33.15 µM -0.745356699496461 0.22354765878365 no 2644 0.228028056481533 849 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1882 5615643 20 µM -0.745786539458544 0.223414993329968 no 2645 0.227898186228081 830 2253075
SGTC_1173 0443-0020 122 µM -0.745925271480279 0.223372184756286 no 2646 0.227856279134028 852 5331295
SGTC_2970 9090938 41.86 µM -0.74715772874394 0.222992090087561 no 2647 0.227484178416421 845 17217104
SGTC_719 2810-4230 27.3 µM -0.747396529861752 0.222918485509564 no 2648 0.227412119722936 849 721079
SGTC_63 0099-0242 26.702 µM -0.749617940248299 0.222234453853428 no 2649 0.226742421352048 860 3898502 YLR359W ADE13
SGTC_1722 st034304 3.6505 µM -0.75005125366009 0.222101164804889 no 2650 0.226611918277934 872 4036148 YLR033W RSC58
SGTC_2393 9031399 185.94 µM -0.75027679253267 0.222031806149066 no 2651 0.226544008436571 864 1526623 YDL150W RPC53
SGTC_1191 1487-1166 10.6 µM -0.752159715857359 0.221453244463688 no 2652 0.225977508041542 876 3955771
SGTC_2384 9036245 200 µM -0.754695659043556 0.220675394620196 no 2653 0.225215805873859 825 6462766
SGTC_655 k060-0012 42 µM -0.754792708752696 0.220645657688192 no 2654 0.22518668470425 861 5994525
SGTC_2019 4016004 108 µM -0.755357317714052 0.220472701790111 no 2655 0.22501730792252 861 45595336
SGTC_2777 climbazole 1.536 µM -0.758430426778364 0.219532683838699 no 2656 0.224096674271144 863 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_222 nsc-310342 10.666 µM -0.758443147215246 0.219528797638313 no 2657 0.224092867968854 867 432556
SGTC_1900 st060200 72.8 µM -0.758458096857403 0.21952423044749 no 2658 0.224088394674374 859 688945
SGTC_74 000s-0487 160.283 µM -0.759347886761293 0.219252493474464 no 2659 0.223822239380728 836 677548
SGTC_2461 5755302 26.15 µM -0.759819255519572 0.219108618408602 no 2660 0.22368131568539 875 2788904
SGTC_126 0417-1624 672.48 µM -0.760175171947166 0.219000018635936 no 2661 0.223574941861404 872 41912 YDL195W SEC31
SGTC_1296 1068-0102 11.9 µM -0.760403864162038 0.218930254767155 no 2662 0.223506607109495 849 767053
SGTC_1824 st053723 68.6 µM -0.760493892637887 0.21890279457272 no 2663 0.223479709262745 852 675225
SGTC_1965 Pectolinarigenin 58.4 µM -0.76081109594652 0.218806058036759 no 2664 0.223384952968011 866 5320438 An anti-inflammatory.
SGTC_2861 9024595 19.48 µM -0.760813037597907 0.21880546597295 no 2665 0.223384373020218 822 16482810
SGTC_1702 st027038 51 µM -0.760869265540527 0.218788320900653 no 2666 0.223367578785252 848 5521182
SGTC_2403 6032726 181.2 µM -0.761259911400619 0.218669226176104 no 2667 0.223250920009034 867 2881040
SGTC_3111 9122088 49.47 µM -0.764552500051793 0.217666910940969 no 2668 0.222269031568984 856 16876704
SGTC_2064 5220758 200 µM -0.76749288892943 0.216774055763414 no 2669 0.221394259765268 858 788518
SGTC_1120 ficusin 1.78878 µM -0.768012684935117 0.216616439198593 no 2670 0.221239824389486 879 6199 A DNA cross-linker.
SGTC_1157 4092-0394 27.6 µM -0.768132699440164 0.216580056894658 no 2671 0.221204175918827 865 3659885
SGTC_2863 9028737 58.44 µM -0.770412837202207 0.215889506786134 no 2672 0.220527520456972 860 6460917
SGTC_1339 1486-1321 22.7 µM -0.770958127655318 0.21572455233163 no 2673 0.220365875549615 865 3469382
SGTC_864 0469-0573 172 µM -0.771862927376501 0.215451004885521 no 2674 0.220097808276352 888 689425
SGTC_3171 9103192 49.47 µM -0.7723865269018 0.215292797373347 no 2675 0.219942765618272 869 13018434
SGTC_2732 terfenadine 20 µM -0.774860891510394 0.214546071679744 no 2676 0.219210931802253 876 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2640 pentamidine 10.38 µM -0.775020878823341 0.214497841814778 no 2677 0.219163661166381 848 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1103 duloxetine 36.1 µM -0.776968161436233 0.213911318385205 no 2678 0.218588777440699 870 60835 A selective serotonin reuptake inhibitor.
SGTC_2104 5389443 200 µM -0.777296504183847 0.213812513305401 no 2679 0.218491928528431 869 2244536
SGTC_780 0109-0199 192 µM -0.777325677925264 0.213803735612925 no 2680 0.218483324554007 851 610414
SGTC_912 3474-0017 2.18 µM -0.777845862639526 0.213647259503715 no 2681 0.218329943462987 867 3360550
SGTC_175 3793-3120 23.7 µM -0.778552001604057 0.213434953520368 no 2682 0.218121831395342 882 5322297
SGTC_2358 9037157 4 µM -0.779583310815704 0.213125103710854 no 2683 0.217818091236196 863 2388925
SGTC_2362 9071156 126 µM -0.779796145452899 0.213061191674418 no 2684 0.21775543777396 883 653133
SGTC_2843 9000894 45.46 µM -0.781623712899342 0.212512852496593 no 2685 0.217217873402849 790 2242070
SGTC_2511 berberine 10.47 µM -0.782156334903332 0.212353201069964 no 2686 0.217061351266817 869 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1041 0206-0046 107 µM -0.78316249891776 0.2120517985542 no 2687 0.216765846803034 891 50494
SGTC_3177 9107506 49.47 µM -0.786917752184124 0.210929101172368 no 2688 0.215665007410771 849 8897194
SGTC_2557 derrustone 83.84 µM -0.786932915641825 0.210924574872902 no 2689 0.215660568876686 872 629853 An antioxidant.
SGTC_2780 5215298 71.43 µM -0.787237646695582 0.21083362457879 no 2690 0.215571381506292 889 2834131
SGTC_853 0419-0306 21 µM -0.790622285157053 0.20982498983991 no 2691 0.214582219214941 870 762713
SGTC_2443 5493264 126.67 µM -0.790678220082183 0.209808344887249 no 2692 0.214565894397055 882 5340055
SGTC_2956 9076196 2.52 µM -0.791435753410058 0.209582996771219 no 2693 0.214344876559028 889 16423868
SGTC_2434 5670830 169.91 µM -0.791518011871015 0.209558535410562 no 2694 0.21432088481213 905 1549830
SGTC_3329 9141233 27.5565 µM -0.792829643026847 0.209168719996241 no 2695 0.21393854164355 860 4909101 YNL103W MET4
SGTC_953 1188-0045 9.7 µM -0.793087251941524 0.209092209083299 no 2696 0.213863494798716 866 6144426
SGTC_3340 9146634 11.102 µM -0.795446279005616 0.208392335084418 no 2697 0.213176974299064 837 4907387
SGTC_2405 ticlatone 3.52 µM -0.796556975324486 0.208063293704892 no 2698 0.212854186685222 900 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1250 0485-0349 40.2 µM -0.797955983838142 0.20764927716453 no 2699 0.212448016783124 882 6842794 YDL195W SEC31
SGTC_2751 anetholtrithion 17.25 µM -0.798454876535061 0.207501754831041 no 2700 0.212303284379517 883 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2445 5742597 35.57 µM -0.798777071567109 0.207406514841857 no 2701 0.212209843887935 878 1774255
SGTC_656 4090-1979 187 µM -0.798910126100463 0.207367191818469 no 2702 0.212171263464295 860 22330961
SGTC_2011 4012611 177 µM -0.799813706389786 0.20710026373926 no 2703 0.211909370290031 873 2049887
SGTC_2049 5262831 67.185 µM -0.800214782008547 0.206981846523479 no 2704 0.211793183395548 881 763417
SGTC_1898 st060199 18.6 µM -0.801161856185768 0.206702382782544 no 2705 0.211518975111062 849 688866
SGTC_1238 0333-0287 48.8 µM -0.802582753284911 0.206283522142651 no 2706 0.211107970040608 866 7226
SGTC_2608 thymoquinone 42.66 µM -0.805096617582855 0.2055437035686 no 2707 0.210381963762124 871 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2741 miltefosine 3.04 µM -0.806005781369326 0.205276529255249 no 2708 0.210119757789936 833 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3010 9080089 71.4286 µM -0.806581402832463 0.205107479133386 no 2709 0.209953845869751 857 17027233
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.80711106139294 0.204952000640308 no 2710 0.209801249914184 874 5355888
SGTC_1476 4112-3294 3.34 µM -0.807589504323327 0.204811616477924 no 2711 0.209663465374295 848 704369
SGTC_1307 1187-1599 12.2 µM -0.807838266354367 0.204738647616975 no 2712 0.209591846593121 877 1538471
SGTC_2543 pimpinellin 60.67 µM -0.808769045034389 0.204465761400059 no 2713 0.209324002363026 871 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2880 9042983 58.44 µM -0.811917716177596 0.203544238340501 no 2714 0.20841942402415 892 6464714
SGTC_2933 9026794 32.47 µM -0.814271973956208 0.202856837908222 no 2715 0.207744580691972 878 17586027
SGTC_1606 st000094 49.2 µM -0.814457463552404 0.202802737320324 no 2716 0.20769146537648 857 1242210
SGTC_11 0438-0307 1.3 µM -0.818908641688312 0.201507077123935 no 2717 0.206419269557984 893 4011476
SGTC_824 1304-0008 100 µM -0.819941167985631 0.201207236996108 no 2718 0.206124823253442 883 768245
SGTC_3117 9124945 49.47 µM -0.820771024386728 0.200966445142865 no 2719 0.205888353083126 866 17592065
SGTC_344 k064-0035 6.43 µM -0.821020114051872 0.200894202816778 no 2720 0.205817405621162 855 5088750
SGTC_2401 5128683 200 µM -0.822130360899903 0.200572392606406 no 2721 0.205501353806725 897 708373
SGTC_2605 digitonin 300 nM -0.822690044640658 0.20041028309196 no 2722 0.205342139033251 867 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1509 1326-1131 80 µM -0.823092194866512 0.200293850956007 no 2723 0.205227783502965 843 768313
SGTC_1510 1123-0200 71.5 µM -0.82515186164292 0.199698165433578 no 2724 0.204642689606556 890 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2335 9018011 154.17 µM -0.825235350767702 0.199674041667042 no 2725 0.20461899362204 870 6458208
SGTC_635 k038-0028 24.7 µM -0.827424892488232 0.199042010650442 no 2726 0.203998138219069 892 4035102
SGTC_2642 cholecalciferol 100 µM -0.829924185554235 0.19832204228912 no 2727 0.203290824827865 863 9821465 A vitamin D precursor, similar to steriods.
SGTC_488 nitrendipine 139 µM -0.830229421851003 0.198234221057419 no 2728 0.203204541711876 893 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1347 1493-0251 600 nM -0.831319822591873 0.197920687562918 no 2729 0.202896489657991 840 3986378
SGTC_149 3970-0822 46.1 µM -0.831701397647659 0.197811040379244 no 2730 0.202788755780649 877 3114250 YBL034C STU1
SGTC_2623 humulene 100 µM -0.831925177579688 0.197746753359451 no 2731 0.202725589671096 891 6187145 An anti-inflammatory.
SGTC_1932 st074806 40.9 µM -0.832829188025645 0.197487179718904 no 2732 0.202470535365732 883 17251235
SGTC_2307 7538926 6.34 µM -0.833339347723008 0.197340785653932 no 2733 0.202326685440019 888 96582
SGTC_2257 7960413 200 µM -0.835758357402757 0.196647527017635 no 2734 0.201645428855497 858 2974689 YIL048W NEO1
SGTC_478 N-arachidonylglycine 10 µM -0.838130360671293 0.195969174391391 no 2735 0.200978746566165 849 5283389
SGTC_2160 5660466 132.927 µM -0.838440058810681 0.195880710883163 no 2736 0.200891799586969 896 2859134
SGTC_836 0330-0104 1.35 µM -0.838525148909432 0.195856409625573 no 2737 0.200867914707306 855 46494820
SGTC_269 exalamide 29 µM -0.838921038033855 0.195743369958919 no 2738 0.200756810625676 889 3316 A derivative of salicylamide.
SGTC_1709 st033179 39.1045 µM -0.841311321453126 0.19506170533373 no 2739 0.200086774907022 886 573381
SGTC_3106 9121286 49.47 µM -0.841544651863272 0.194995241212634 no 2740 0.200021440653426 864 15943471
SGTC_3305 9127027 53.8275 µM -0.841965267376353 0.194875463754078 no 2741 0.199903697580274 883 41905295
SGTC_2126 5251174 33.877 µM -0.842970551218125 0.194589373311605 no 2742 0.199622456967624 888 790722
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.843396198274163 0.194468316865095 no 2743 0.199503448712821 873 3256 An antibiotic and ribosome inhibitor.
SGTC_1960 st011366 51.8 µM -0.843657464640021 0.19439403393253 no 2744 0.199430421426682 886 3972846
SGTC_1771 st048882 4.1505 µM -0.844191917135342 0.194242132875334 no 2745 0.199281085266839 891 4580403
SGTC_1232 0279-0259 161 µM -0.844445451445724 0.194170099128808 no 2746 0.199210266530287 874 1560000
SGTC_979 1426-2828 121 µM -0.845085084369422 0.193988440005561 no 2747 0.199031667768048 892 747872
SGTC_143 4032-1194 15.74 µM -0.845360519102755 0.193910246997832 no 2748 0.198954790412147 888 1806963
SGTC_2177 5811945 192 µM -0.847027986616929 0.193437280869417 no 2749 0.198489761131398 883 5343475
SGTC_3301 9125354 19.7965 µM -0.847746447241544 0.193233711402148 no 2750 0.19828959657408 857 41905162
SGTC_1174 0739-0097 51.1 µM -0.847885353950281 0.193194368503418 no 2751 0.198250910947936 895 728447
SGTC_345 1362-0200 395 µM -0.849849650608586 0.192638539377091 no 2752 0.197704340651729 907 1419823
SGTC_3125 9127534 49.47 µM -0.852266978877472 0.191955860683412 no 2753 0.197032964569441 856 1639235
SGTC_1979 st071809 45.3 µM -0.853189055611823 0.191695847223835 no 2754 0.196777235805357 907 4976333
SGTC_2634 4'-methoxyflavone 100 µM -0.853791526602067 0.191526074924793 no 2755 0.196610255121631 900 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_581 0958-0271 211 µM -0.855722982030852 0.190982424991933 no 2756 0.196075512500629 879 4591145
SGTC_2319 6033012 152.6 µM -0.856364611791279 0.190802034056946 no 2757 0.195898066310051 901 847246
SGTC_2779 methotrexate 400 µM -0.856690470315641 0.190710460639178 no 2758 0.195807985688519 884 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2062 5245942 200 µM -0.857001639249178 0.190623040500839 no 2759 0.195721989339312 901 1376160
SGTC_2298 7976326 193.81 µM -0.857448664651389 0.190497495758737 no 2760 0.195598487085519 886 2235818
SGTC_1117 retinoic acid 1.10837 µM -0.857583323968055 0.190459687347457 no 2761 0.195561293264906 897 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1177 0983-0204 23.6 µM -0.858362888311386 0.190240898965685 no 2762 0.195346056691603 865 766818
SGTC_338 4055-0136 114 µM -0.858562798548079 0.190184818106326 no 2763 0.195290884961359 892 2900563
SGTC_2926 9010726 65.15 µM -0.85860683010344 0.190172467290317 no 2764 0.195278734294312 914 2994293
SGTC_1820 st053765 18.6 µM -0.861193231784231 0.189447848600365 no 2765 0.194565813562378 873 3690829
SGTC_2898 9056270 58.44 µM -0.861736326359471 0.189295908754162 no 2766 0.194416315391576 830 19154699
SGTC_3164 9100705 49.47 µM -0.863565680139869 0.188784668398716 no 2767 0.193913262099763 854 17174235
SGTC_485 niflumic acid 177 µM -0.866031864245166 0.188096804554653 no 2768 0.193236344004906 904 4488 A COX2 inhibitor.
SGTC_2736 butenafine 14.65 µM -0.869180718677599 0.18722078324067 no 2769 0.192374145938586 890 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2479 5617353 43.85 µM -0.871995234230989 0.186439915100059 no 2770 0.191605488731524 883 2731746
SGTC_2711 st079103 59.1 µM -0.874289253652418 0.185804949594932 no 2771 0.190980375071368 903 54693780
SGTC_2743 auranofin 4.32 µM -0.874928596706393 0.18562822403435 no 2772 0.190806379082269 858 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1405 3909-7894 12 µM -0.875029148645238 0.185600439220872 no 2773 0.190779022919006 862 7104060
SGTC_1039 k821-0043 94 µM -0.877156006010665 0.185013344320762 no 2774 0.190200954013717 881 15992768
SGTC_1730 st033808 45.1 µM -0.877480756807269 0.184923802186373 no 2775 0.190112783217183 896 1045166
SGTC_1835 st008666 49.2 µM -0.880107750198717 0.184200463013496 no 2776 0.189400470513632 886 690455
SGTC_1696 st025591 34.7925 µM -0.88065034530233 0.184051279875915 no 2777 0.189253550075006 879 2787147
SGTC_558 k064-0027 21.3 µM -0.88096213931619 0.183965588098866 no 2778 0.189169156235658 866 5088526
SGTC_442 cape 100 µM -0.882347255290387 0.183585210729231 no 2779 0.188794524652796 888 5281787
SGTC_2070 5230947 200 µM -0.884463711757933 0.183004941733808 no 2780 0.188222971609401 906 2835538
SGTC_258 haloperidol 50.781 µM -0.884508937459538 0.182992554701868 no 2781 0.18821076998632 902 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_734 2023-0417 80 µM -0.88469852180668 0.18294063444872 no 2782 0.188159626577904 904 3935732
SGTC_1982 st072467 71.9 µM -0.886307566369298 0.18250034588393 no 2783 0.187725906447435 913 3163533
SGTC_93 0109-0045 59.227 µM -0.88888779067354 0.181795692998404 no 2784 0.187031693883121 911 88733
SGTC_589 1227-0070 34.1 µM -0.889348815240384 0.181669967780005 no 2785 0.186907822088237 881 2841384
SGTC_91 0417-1751 58.384 µM -0.889419455881524 0.181650708299898 no 2786 0.186888846277881 912 6795624
SGTC_2450 5739737 12.93 µM -0.891907423910773 0.180973203217505 no 2787 0.186221277558277 894 2262825
SGTC_3216 9129716 49.47 µM -0.892722867336058 0.180751492669831 no 2788 0.186002800645418 890 8056934
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.894991725517337 0.180135510357421 no 2789 0.185395755616782 901 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2936 9038235 15.59 µM -0.897286132942932 0.17951393336854 no 2790 0.184783127053176 885 4749415
SGTC_1974 st069448 26.9 µM -0.897907019193058 0.179345961370686 no 2791 0.184617561112253 881 6323587 YNR016C ACC1
SGTC_806 3966-4455 5.86 µM -0.903481812156819 0.177842210033514 no 2792 0.183135118431436 902 714982
SGTC_1036 k216-0215 33.5 µM -0.904354601006157 0.17760750498702 no 2793 0.182903701482423 848 622330
SGTC_177 1327-0068 8.361 µM -0.904597333838014 0.177542265513061 no 2794 0.182839374160154 891 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2033 5192550 145 µM -0.905586229272419 0.177276635745989 no 2795 0.182577450132655 865 182073
SGTC_2773 thioridazine 9.09 µM -0.906434300958278 0.177049033026112 no 2796 0.182353012171071 910 5452 An antipsychotic.
SGTC_1164 k060-0068 93.7 µM -0.907077265150211 0.176876599488773 no 2797 0.182182969829806 905 5963676
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.907772417844511 0.176690289219233 no 2798 0.181999236930783 917 6710655
SGTC_1567 st069303 68.4 µM -0.908982774489416 0.176366193584695 no 2799 0.181679609234122 911 5581319
SGTC_291 SEC14.278 35.5 µM -0.911728421903654 0.175632390516045 no 2800 0.180955849170418 899 1068044
SGTC_2193 5925765 200 µM -0.912013801203257 0.175556231052179 no 2801 0.1808807262151 912 877370
SGTC_2390 9097792 176.6 µM -0.912473631886161 0.175433559609163 no 2802 0.18075972198467 890 4497149
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.91299467582588 0.175294623670764 no 2803 0.18062267086088 896 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1406 3909-7906 11.9 µM -0.913948650972068 0.175040427849541 no 2804 0.180371913987063 886 X1406
SGTC_2902 5787006 60.46 µM -0.914898244848091 0.17478763183092 no 2805 0.18012252578325 901 591003
SGTC_261 5-fluorouridine 15.376 µM -0.916367616914901 0.174396920112499 no 2806 0.179737057065201 903 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_682 0kpi-0099 17 µM -0.918021270236153 0.173957871410998 no 2807 0.179303865138535 912 1714895 YML126C ERG13
SGTC_1149 3909-7961 23.3 µM -0.918252502468396 0.17389653478568 no 2808 0.179243343780065 909 735261
SGTC_387 norethindrone acetate 66.7 µM -0.919902860257685 0.173459160586142 no 2809 0.178811762032484 921 541197
SGTC_3155 9099265 49.47 µM -0.920567123121255 0.173283316898044 no 2810 0.178638236769976 900 25236499
SGTC_2363 9053361 176 µM -0.921655273090895 0.172995507152868 no 2811 0.17835420877779 913 6469797 YMR079W SEC14
SGTC_1862 st057513 3.81 µM -0.923124546258309 0.172607375930551 no 2812 0.177971152087672 914 5393163
SGTC_2231 micatex 6.853 µM -0.923656538315196 0.172466979024843 no 2813 0.177832583561533 929 20737 An antifungal of unknown mechanism.
SGTC_1447 4239-0816 81.9 µM -0.924417731863696 0.172266220736229 no 2814 0.177634433068125 898 1341554
SGTC_1254 0550-0035 264 µM -0.924965668076909 0.172121799581399 no 2815 0.177491883045239 924 15121435
SGTC_2474 5321570 43.32 µM -0.925831934130816 0.171893633005178 no 2816 0.177266664312666 919 2841384
SGTC_1678 st019265 80.2 µM -0.927449130356697 0.171468195357107 no 2817 0.176846695976892 903 5367020
SGTC_1666 st014829 29 µM -0.931983946934848 0.170278808782485 no 2818 0.175672410842268 913 3858230
SGTC_2856 9022925 19.48 µM -0.932009572279995 0.170272102848902 no 2819 0.175665789259744 920 4944862
SGTC_3326 9140064 16.379 µM -0.932261253789601 0.170206248942594 no 2820 0.175600763227243 919 1868434
SGTC_681 1642-0006 26.6 µM -0.933469628014187 0.169890298221803 no 2821 0.175288772454581 939 4446530
SGTC_3210 9128157 49.47 µM -0.93568189140828 0.169312838065373 no 2822 0.174718498455024 918 17590849
SGTC_1802 st050112 57.9 µM -0.935850790709806 0.169268802638877 no 2823 0.174675008289505 911 4662563
SGTC_3084 9116877 49.47 µM -0.937781829825199 0.16876586474308 no 2824 0.174178270357637 885 27241325
SGTC_2477 5967686 25.23 µM -0.939392906406423 0.168346996450409 no 2825 0.173764526844386 927 776118
SGTC_3095 9117207 49.47 µM -0.939502801257792 0.168318448961897 no 2826 0.173736327341668 911 17015229
SGTC_2407 paclitaxel 400 µM -0.940448583391693 0.168072890969794 no 2827 0.173493755832161 954 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1375 2910-0797 186 µM -0.942489630916496 0.167543749919981 no 2828 0.172971008698655 914 742508
SGTC_2973 9094665 17.96 µM -0.944604651386535 0.166996564875892 no 2829 0.172430375732589 894 25237061 YIL048W NEO1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.946398383271478 0.166533405849789 no 2830 0.171972714852479 921 676296 Flavone; oxidizing agent.
SGTC_1825 st052143 62.6 µM -0.948342596340736 0.166032328491848 no 2831 0.171477536200414 932 674173
SGTC_735 3076-0345 636 µM -0.949331621461577 0.165777803653908 no 2832 0.171225987838571 912 2888990
SGTC_1331 1472-0049 76.2 µM -0.949682700749685 0.165687514370163 no 2833 0.171136751206226 915 24051409
SGTC_1719 st032227 49.2 µM -0.951606688332621 0.165193275023074 no 2834 0.170648244127681 906 3125804
SGTC_1159 4092-0538 61.2 µM -0.952538432875541 0.164954269166863 no 2835 0.170411992119963 944 717301
SGTC_1732 st034308 51.822 µM -0.954069655308005 0.164561975251664 no 2836 0.170024192474537 885 830119
SGTC_1345 1488-0192 31.4 µM -0.956108423341201 0.164040589125647 no 2837 0.169508729789855 918 658348
SGTC_3233 9132340 49.47 µM -0.956712344861492 0.163886350691185 no 2838 0.169356232730904 945 17682950
SGTC_1478 0453-0656 35.7 µM -0.958452556311983 0.163442436156609 no 2839 0.168917302141632 945 5258496
SGTC_2862 9027634 71.43 µM -0.963056323587288 0.162271820309382 no 2840 0.167759629330036 908 5012562
SGTC_3059 1327-0034 3 µM -0.964120651748532 0.162001968629386 no 2841 0.167492719971077 903 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2135 5326629 150.42 µM -0.964417616463109 0.161926727846828 no 2842 0.167418296801631 931 5020077
SGTC_661 1304-0007 33.6 µM -0.964746233154529 0.161843494066069 no 2843 0.1673359660804 920 3117130
SGTC_2032 5185112 25.99 µM -0.965249612346233 0.16171604957764 no 2844 0.16720990144977 888 5718189
SGTC_1279 0874-0590 65.2 µM -0.966035090696305 0.16151731451016 no 2845 0.167013311166059 922 3523074
SGTC_1155 4088-0394 48.2 µM -0.966993208704193 0.161275115291954 no 2846 0.166773714340943 914 2326248
SGTC_3349 9149703 23.001 µM -0.968287276776681 0.160948368729019 no 2847 0.166450458617769 910 4910494
SGTC_231 b-estradiol 524 µM -0.969800528997686 0.160566827588854 no 2848 0.166072964562628 931 450 A steroid.
SGTC_1257 0669-0121 16 µM -0.972557112228578 0.159873321060262 no 2849 0.165386733408741 911 4307855
SGTC_152 4469-0003 551.229 µM -0.974893604507057 0.159287038273425 no 2850 0.164806519423463 898 697280
SGTC_1885 st057546 99.9 µM -0.975145738527169 0.159223855982106 no 2851 0.164743986664757 898 702008
SGTC_3090 9117696 49.47 µM -0.975159430141039 0.15922042546904 no 2852 0.164740591393338 893 7923821
SGTC_1502 4534-4282 27.7 µM -0.975359046020401 0.159170416053364 no 2853 0.164691095431233 941 3278949
SGTC_2112 5488546 200 µM -0.976827748623379 0.158802780941231 no 2854 0.164327218026959 954 600757
SGTC_565 1418-0001 44.5 µM -0.977378710444381 0.158665011802545 no 2855 0.164190849412179 927 2862145
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.977765556475399 0.158568326997595 no 2856 0.164095144982008 914 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1136 pergolide 1.05886 µM -0.977769598235175 0.158567317040631 no 2857 0.164094145255037 931 47811 A dopamine receptor agonist.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.979243926516767 0.158199192573887 no 2858 0.163729734571296 910 165521
SGTC_2685 mycophenolic acid 18.85 µM -0.980743870566673 0.157825248138875 no 2859 0.163359531932248 903 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2184 6075246 200 µM -0.980995020581493 0.157762691820288 no 2860 0.163297598541715 902 2267320
SGTC_415 dibenzyl ketone 100 µM -0.982734398651309 0.157329895444798 no 2861 0.162869088057304 933 7593
SGTC_373 0844-0104 25.9 µM -0.983222253301373 0.157208646529237 no 2862 0.162749032359309 915 5375804
SGTC_2691 st077356 60.2 µM -0.988675723830647 0.1558574519445 no 2863 0.161410911978246 934 2839272
SGTC_292 k038-0015 474 µM -0.989600012004923 0.155629204120806 no 2864 0.161184832071808 936 46368540
SGTC_2340 7987427 183.45 µM -0.989822568514404 0.155574277979378 no 2865 0.161130425862324 914 2239331
SGTC_1081 sertraline 6 µM -0.991198853315156 0.155234899938465 no 2866 0.160794245198486 925 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1672 st016598 6.51 µM -0.992411804427549 0.154936203776442 no 2867 0.160498341468266 930 4665860 YNL267W PIK1
SGTC_989 1501-0895 10.3 µM -0.992929347420161 0.15480887146055 no 2868 0.160372193366229 912 2830112
SGTC_125 0133-0007 11.75 µM -0.993272846825423 0.154724397675666 no 2869 0.160288503160654 910 26541
SGTC_2896 9052656 71.43 µM -0.994952196394632 0.154311848517836 no 2870 0.159879757359869 910 6469436
SGTC_3017 9080681 49.47 µM -0.996100595099763 0.154030151954883 no 2871 0.159600635381511 948 16451914
SGTC_1216 1165-0504 9.65 µM -0.996934352855726 0.153825848578444 no 2872 0.159398187834009 943 6304004
SGTC_1161 k007-0610 110 µM -0.997844400822207 0.153603055925934 no 2873 0.159177407997375 913 5843850
SGTC_1734 st037168 69.4 µM -0.997853934826323 0.153600722998001 no 2874 0.159175096085637 943 708907
SGTC_519 k048-0011 62.8 µM -0.998860375711499 0.153354583404262 no 2875 0.158931166775146 911 6836379
SGTC_2847 9005661 71.43 µM -0.998947697384155 0.15333323995939 no 2876 0.158910014329829 906 2991449
SGTC_1564 D-Arginine 115 µM -1.00251715959499 0.152462464914842 no 2877 0.158046941574156 945 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_425 3825-7017 13.1 µM -1.00299160043863 0.152346972013533 no 2878 0.157932456983687 924 3397440
SGTC_2937 9044753 11.33 µM -1.0040022733104 0.152101138078396 no 2879 0.157688758920365 896 6465530 YGL099W LSG1
SGTC_3033 9090887 49.47 µM -1.00472495601134 0.151925515885671 no 2880 0.157514653915568 936 19325384
SGTC_333 3486-0131 40.1 µM -1.00605499033009 0.151602650829748 no 2881 0.157194559182452 901 6744690
SGTC_871 0574-0004 149 µM -1.00613721925122 0.151582704788732 no 2882 0.157174783483475 942 9551173
SGTC_3174 9107204 49.47 µM -1.00722836811188 0.151318193006016 no 2883 0.156912521808528 949 3938802
SGTC_2020 4017018 200 µM -1.01165181521455 0.150249025752645 no 2884 0.155852280944475 959 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_493 zm226600 134 µM -1.01187006794549 0.150196403731993 no 2885 0.155800091248883 932 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2644 guaiazulene 100 µM -1.01388364315234 0.149711498371419 no 2886 0.155319138591523 912 3515 A coloring agent.
SGTC_817 1391-0715 46 µM -1.0140820338983 0.149663778872824 no 2887 0.155271805038093 933 1353946
SGTC_38 0929-0051 58.268 µM -1.01449256864043 0.1495650639983 no 2888 0.155173886816062 938 1379719
SGTC_2426 5582046 32.21 µM -1.01614118233112 0.14916908529735 no 2889 0.154781080240036 935 2251934
SGTC_165 k038-0023 64.381 µM -1.01798799880202 0.148726332678072 no 2890 0.154341829729127 953 46368543
SGTC_287 k060-0039 29.6 µM -1.01882938831838 0.148524910940441 no 2891 0.154141985532589 931 5861974
SGTC_807 1315-0151 48 µM -1.01949836528593 0.148364893576493 no 2892 0.153983214424228 953 4011080
SGTC_1455 4262-0120 131 µM -1.02111387865838 0.147978943055216 no 2893 0.153600244199929 932 1529587
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.02194799950515 0.147779932627228 no 2894 0.153402756356466 892 279621
SGTC_1801 st050089 28.441 µM -1.02256472956336 0.147632904117629 no 2895 0.153256846523088 927 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_998 3996-0085 177 µM -1.02372225237207 0.147357215162364 no 2896 0.152983240921613 924 715391
SGTC_993 3909-8757 62.7 µM -1.02457985332878 0.147153181685083 no 2897 0.152780737317464 931 4288324 YLR208W SEC13
SGTC_89 0302-0250 142.109 µM -1.02528012988166 0.14698671808873 no 2898 0.152615514320776 954 4203518 YLR208W SEC13
SGTC_2505 galangin 7.89 µM -1.02611008723771 0.14678959149842 no 2899 0.152419848039475 938 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3327 9140648 26.9345 µM -1.02707975918516 0.146559505475608 no 2900 0.15219145438006 937 8029710
SGTC_2154 5570129 200 µM -1.02790034442647 0.146364984286444 no 2901 0.151998353767885 966 673366
SGTC_10 0279-0212 42.575 µM -1.0290203177158 0.146099772497293 no 2902 0.151735063722489 948 39851 YBR002C RER2
SGTC_2171 5739187 198.077 µM -1.02966359282213 0.145947589784003 no 2903 0.151583975863045 914 2262761
SGTC_1958 st076513 41.9 µM -1.02977612063308 0.145920979483876 no 2904 0.151557556415861 947 732122 YGL099W LSG1
SGTC_671 0560-0003 407 µM -1.03158413697966 0.1454938712529 no 2905 0.151133487366821 926 3238678
SGTC_652 0437-0092 114 µM -1.03300168132612 0.145159592907224 no 2906 0.1508015559183 924 3091274
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.03513203212245 0.144658196770048 no 2907 0.150303627521048 912 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_860 0443-0016 25.1 µM -1.03575136717883 0.144512650141252 no 2908 0.150159075691669 928 5337942
SGTC_1770 st043884 66.3 µM -1.03747815644022 0.144107367812116 no 2909 0.149756535302042 964 670149
SGTC_2065 5221596 34.26 µM -1.03764249427485 0.144068837236118 no 2910 0.149718263245764 930 788581
SGTC_691 1548-0686 185 µM -1.03782440195712 0.144026195343059 no 2911 0.149675907019466 920 46495133
SGTC_2417 cerulenin 830 nM -1.0380203517782 0.143980271285336 no 2912 0.14963029010184 931 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3002 9075603 71.4286 µM -1.03886918786525 0.143781446678098 no 2913 0.149432789071559 917 20105405
SGTC_2744 captopril 92.04 µM -1.04034342925491 0.14343657255674 no 2914 0.149090186990535 925 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3069 9117009 49.47 µM -1.0406430401486 0.143366551939826 no 2915 0.149020623978267 932 41904981
SGTC_1449 4112-4002 201 µM -1.04130036136961 0.143213013444314 no 2916 0.148868084528854 935 2059539
SGTC_577 r071-0003 38.6 µM -1.04198931670028 0.143052205035965 no 2917 0.148708316024472 972 4568517 YMR134W ERG29
SGTC_1848 st056003 16.4 µM -1.04238834428908 0.142959124197699 no 2918 0.148615834096926 903 146492
SGTC_2647 atorvastatin 60.16 µM -1.04327962098898 0.142751364644373 no 2919 0.148409403339488 922 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_62 0180-0423 3.232 µM -1.0435474787738 0.142688966015623 no 2920 0.148347401643766 942 30102 YGL099W LSG1
SGTC_2038 4100038 30.985 µM -1.04409915877086 0.142560507886101 no 2921 0.148219757524905 905 3596803
SGTC_1492 4158-0558 28.5 µM -1.04720428695408 0.141838941079189 no 2922 0.147502684260034 906 3967268
SGTC_2700 st077718 96.8 µM -1.04766903446802 0.141731156642494 no 2923 0.147395559518312 944 904970
SGTC_575 k072-0246 11.9 µM -1.04811230516633 0.141628404820719 no 2924 0.147293433790462 954 6796779
SGTC_3118 9124250 49.47 µM -1.04910141186377 0.141399308128242 no 2925 0.147065723193992 918 1504786
SGTC_2117 5521686 200 µM -1.04956643576856 0.141291686231805 no 2926 0.146958747736568 956 803312
SGTC_3093 9117344 49.47 µM -1.04997982656544 0.141196060575353 no 2927 0.146863693937333 919 24824913
SGTC_2948 9070189 9.45 µM -1.05069980786398 0.141029619114758 no 2928 0.146698242149428 883 6473636 YDL196W YDL196W
SGTC_394 menadione 8.33 µM -1.05396964744461 0.140275389796056 no 2929 0.145948406888799 954 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1600 coumarin 106 71.1 µM -1.0618715727016 0.138464038263031 no 2930 0.144146995970259 947 100336 A hepatotoxic, DNA x-linker.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.06480297304485 0.137796147138449 no 2931 0.143482549740632 915 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_233 rapamycin 362 pM -1.06508806564707 0.137731309040436 no 2932 0.143418039690013 941 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1051 3253-3903 78 µM -1.06721276658238 0.137248747899719 no 2933 0.14293788444787 926 5509239
SGTC_3113 9123498 49.47 µM -1.06926756462383 0.136783162716467 no 2934 0.142474560810196 966 8897275
SGTC_2195 6536160 144.242 µM -1.07040101139997 0.136526803918491 no 2935 0.142219422118539 940 3834386
SGTC_541 4513-1321 94 µM -1.07047512431423 0.136510052787048 no 2936 0.142202750089007 915 747515
SGTC_1767 st044992 70.3 µM -1.07111629947414 0.136365191933839 no 2937 0.142058570103136 945 9600693
SGTC_2946 9065502 71.43 µM -1.07262735233476 0.136024215494948 no 2938 0.141719173677644 887 16489101
SGTC_3206 9114350 49.47 µM -1.07504305121561 0.135480314560969 no 2939 0.141177727103093 924 17087243
SGTC_936 3005-4620 401 µM -1.07621457426744 0.135217080418118 no 2940 0.140915651574492 945 777207
SGTC_1482 3346-2049 8.48 µM -1.07653473924495 0.13514520233385 no 2941 0.140844086534656 945 3826804
SGTC_2467 5474540 200 µM -1.07861565563631 0.134678668338136 no 2942 0.140379549636567 915 5413519
SGTC_2906 7926292 26.41 µM -1.07935190412461 0.134513869080472 no 2943 0.140215441405842 962 2966319
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.08213187321279 0.133892859109358 no 2944 0.1395969674433 939 6312947
SGTC_401 neomycin 50 µM -1.08383118867315 0.133514225331977 no 2945 0.139219826954268 926 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_886 0866-0150 153 µM -1.08460972250376 0.133341002153197 no 2946 0.139047273525664 949 271463
SGTC_1935 st074532 41.6 µM -1.0848194986538 0.133294353576168 no 2947 0.139000803867643 932 2829742
SGTC_14 0354-0009 295 µM -1.08601589817796 0.133028521119034 no 2948 0.138735979295085 956 1713507
SGTC_2148 5546263 113.568 µM -1.08802104841847 0.132583808156297 no 2949 0.138292907781855 971 792097
SGTC_862 0452-0056 10.2 µM -1.08874061100223 0.132424469714803 no 2950 0.138134143823528 956 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1402 3909-7673 35.9 µM -1.08953265365471 0.132249234063974 no 2951 0.137959531641118 948 5328014
SGTC_606 k015-0008 38.6 µM -1.08961916670351 0.132230103153621 no 2952 0.137940468267344 984 1970475
SGTC_1002 4049-0206 172 µM -1.09023474199587 0.132094034080368 no 2953 0.137804876541859 926 4662749
SGTC_2518 prenyletin 46.28 µM -1.09312933061601 0.131455497948068 no 2954 0.137168509835611 940 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2469 5655019 90.81 µM -1.09412456780732 0.131236445194091 no 2955 0.136950174391449 957 2788239
SGTC_706 4262-0057 46.9 µM -1.09423312267848 0.131212567409737 no 2956 0.136926373963433 971 883298
SGTC_122 0236-0016 402.397 µM -1.09428590318682 0.131200958866611 no 2957 0.136914802968984 944 6808838
SGTC_2576 guaiol 23.12 µM -1.09513151887045 0.131015070900263 no 2958 0.136729510984862 919 227829
SGTC_1363 1636-0063 10.4 µM -1.09564673796509 0.130901901809496 no 2959 0.136616699851484 939 6072185
SGTC_372 0155-0182 15.9 µM -1.09588609663762 0.130849349100409 no 2960 0.13656431211143 857 771486
SGTC_2663 amphotericin b 100 µM -1.09669243873485 0.130672418905394 no 2961 0.136387931454362 952 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2269 7935389 174.42 µM -1.10409057329585 0.129056815596466 no 2962 0.134776925022766 935 97605
SGTC_416 estradiol valerate 100 µM -1.11263165551026 0.127208904897629 no 2963 0.132933329590886 962 13791 A steroid.
SGTC_1649 st011737 51.3 µM -1.11537720736516 0.126618818509802 no 2964 0.132344406276061 896 1761035
SGTC_453 enantio-paf c16 10 µM -1.11567205308053 0.126555562483287 no 2965 0.132281268700273 955 13871343 A lipid and platelet activating factor
SGTC_1961 st076550 68.7 µM -1.11610651901795 0.126462392537326 no 2966 0.13218827101846 947 1579337
SGTC_991 3996-0057 64.7 µM -1.11666763907502 0.126342132713864 no 2967 0.132068229664109 945 715343
SGTC_833 3852-0053 558 µM -1.11982449192751 0.125667038187003 no 2968 0.131394280073421 991 3123681
SGTC_66 0109-0187 42.4 µM -1.11995520078836 0.125639140396347 no 2969 0.131366426612001 955 759417
SGTC_466 geldanamycin 89.2 µM -1.11999122534655 0.12563145226959 no 2970 0.131358750659842 941 5288382 HSP90 inhibitor.
SGTC_2967 9089538 49.85 µM -1.12015870332724 0.125595714519175 no 2971 0.131323069265419 964 728216
SGTC_16 erodoxin 22.806 µM -1.12254873882543 0.125086483050506 no 2972 0.130814598388259 964 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_638 3970-0837 4.09 µM -1.12322708620573 0.124942214460618 no 2973 0.130670530828173 940 4118451 YLR208W SEC13
SGTC_3248 9135562 49.47 µM -1.12605455627734 0.124342130040279 no 2974 0.130071213818404 953 17650701
SGTC_1670 st016595 4.04 µM -1.12863796603152 0.123795608210849 no 2975 0.129525293973172 965 597879
SGTC_2473 5854593 8.94 µM -1.13218932010022 0.12304706528817 no 2976 0.12877742458489 954 2872951
SGTC_1866 st057638 64 µM -1.13500279174502 0.122456307533794 no 2977 0.128187074330443 931 688802
SGTC_3075 9116269 49.47 µM -1.1351683441525 0.122421607833264 no 2978 0.128152395145478 951 17015205 YNL244C SUI1
SGTC_1066 ketoconazole 628 nM -1.13521024101342 0.122412827366727 no 2979 0.128143619809933 965 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1565 sinapyl alcohol 95.1 µM -1.13532936977015 0.122387863566114 no 2980 0.128118670464194 951 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.13544877294978 0.122362845844843 no 2981 0.128093667031429 939 5379071
SGTC_449 xestospongin c 11.1929 µM -1.13587616140814 0.122273327518476 no 2982 0.128004198211175 956 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2238 6671620 73.2395 µM -1.14019064396809 0.121372214872365 no 2983 0.127103442254503 944 729941
SGTC_3097 9117246 49.47 µM -1.14118054238374 0.121166127258 no 2984 0.126897399849885 951 16423892
SGTC_2172 5754775 163.918 µM -1.14135188389679 0.121130480557141 no 2985 0.126861759589814 940 2263357
SGTC_2084 5306078 60.6385 µM -1.14173690776251 0.121050405281234 no 2986 0.126781697297462 972 679340
SGTC_1240 0356-0016 42.1 µM -1.14697154140779 0.119965426938269 no 2987 0.125696691441016 916 4305613
SGTC_2389 9091542 195.52 µM -1.14839492571691 0.119671592257169 no 2988 0.125402783755688 949 3626624 YOL127W RPL25
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.14969197634774 0.119404279448357 no 2989 0.125135380113986 971 390807
SGTC_2213 7173844 200 µM -1.14986756321279 0.119368124661644 no 2990 0.125099211251886 972 892728
SGTC_13 0199-0087 65 µM -1.15037348402562 0.119263994582763 no 2991 0.124995038247427 964 4589825
SGTC_227 fluconazole 33.516 µM -1.15082352281584 0.119171420196973 no 2992 0.124902422721793 955 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3096 9117468 49.47 µM -1.15385467954016 0.118549223055542 no 2993 0.124279876129172 937 41316311
SGTC_53 0973-0023 39.979 µM -1.15418518017801 0.11848152116171 no 2994 0.12421212852758 957 674768
SGTC_511 blebbistatin 171 µM -1.1552086443382 0.11827204147665 no 2995 0.124002497832162 980 3476986 A myosin inhibitor.
SGTC_3307 9126885 69.2785 µM -1.15723165676409 0.117858747815328 no 2996 0.123588863641651 970 24824909
SGTC_556 4058-0063 51.5 µM -1.16215080969179 0.116858050080122 no 2997 0.122587105815657 974 6615692
SGTC_2094 5332512 191.667 µM -1.16360562044611 0.116563256870275 no 2998 0.122291936326251 972 755774
SGTC_167 3672-0051 66.205 µM -1.1642516641622 0.116432516099956 no 2999 0.122161019304045 953 3237971
SGTC_816 0325-0417 81.3 µM -1.16631406678948 0.116015840998526 no 3000 0.121743743936363 953 68101
SGTC_1407 3909-7909 12.3 µM -1.16857102330661 0.115561073710315 no 3001 0.121288254280661 940 4411780
SGTC_2701 st077767 14.721 µM -1.16952450868882 0.115369331439006 no 3002 0.121096186326879 964 5721188
SGTC_3133 9127736 49.47 µM -1.1703705525098 0.115199384675036 no 3003 0.120925940399772 943 27243420
SGTC_726 3448-4391 34.2 µM -1.17555917127751 0.114161027108767 no 3004 0.119885539485725 973 1356692
SGTC_968 1309-0633 340 µM -1.17652811175277 0.11396786163539 no 3005 0.119691952811813 967 3761976
SGTC_2626 ethyl orsellinate 100 µM -1.17947837736264 0.113381138631482 no 3006 0.119103870885988 975 75653 A natural product.
SGTC_2189 6047310 154.431 µM -1.18059940511299 0.113158764233348 no 3007 0.118880950036663 966 711535
SGTC_1341 1486-1360 280 µM -1.18292960050226 0.112697527538726 no 3008 0.118418524617739 983 3976547
SGTC_3162 9099653 49.47 µM -1.18509701140354 0.112269718785416 no 3009 0.117989546293134 954 25237511
SGTC_503 tyrphostin 8 294 µM -1.1882679908846 0.111645916281405 no 3010 0.117363922161376 1001 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_328 k915-0120 63.5 µM -1.19114133834185 0.111082809615763 no 3011 0.116799051941355 964 6624543
SGTC_1523 st012844 44.7 µM -1.19133032577586 0.111045844062388 no 3012 0.116761966644133 984 4274103
SGTC_2241 6772625 37.8075 µM -1.19167175246027 0.11097908404207 no 3013 0.116694989121852 954 2285411
SGTC_2201 6605497 169.863 µM -1.19177333755751 0.110959226402231 no 3014 0.116675066477369 979 670741
SGTC_136 0097-0015 404.482 µM -1.19303280604329 0.110713239532386 no 3015 0.116428262594165 975 4861337
SGTC_2560 caryophyllene 100 µM -1.19334435003582 0.110652452190201 no 3016 0.116367269994893 981 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1827 berberine 7.24 µM -1.19666232274055 0.110006544821203 no 3017 0.115719099079147 939 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_268 camptothecin 39.6153 µM -1.1970489848929 0.109931449938444 no 3018 0.115643731208771 993 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2232 chlorophetanol 41.5365 µM -1.19744651153104 0.109854283387945 no 3019 0.115566282001582 987 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_367 0335-0881 7.1 µM -1.19763348798507 0.109818001585644 no 3020 0.11552986655153 987 23828853
SGTC_1171 0368-0077 21.4 µM -1.19906738964146 0.109540046338313 no 3021 0.115250871497009 975 3239779
SGTC_1850 st056238 17 µM -1.20030933342069 0.109299709822082 no 3022 0.115009613133316 955 5393177
SGTC_1340 1486-1359 257 µM -1.20051189186302 0.109260547395676 no 3023 0.114970298488265 951 4309068
SGTC_137 0438-0332 85.389 µM -1.20308595666973 0.108763758384677 no 3024 0.114471529605559 975 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3294 9122953 26.2835 µM -1.20390323770823 0.108606365140978 no 3025 0.114313490124706 987 16459826
SGTC_371 0195-0006 7.36 µM -1.20501528074339 0.108392469384959 no 3026 0.114098701455416 941 3928593
SGTC_3260 9137109 49.47 µM -1.20522199162857 0.108352743041889 no 3027 0.114058807407769 960 17478346
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.20741598964214 0.107931739293162 no 3028 0.113635990374524 961 688667
SGTC_198 3454-2873 16.191 µM -1.20742644126827 0.107929736565882 no 3029 0.113633978863791 973 710957
SGTC_340 k038-0059 454 µM -1.20853301317472 0.107717848054221 no 3030 0.113421152610112 966 23733424
SGTC_252 miconazole 1.30953 nM -1.20884248525763 0.107658643406261 no 3031 0.11336168294702 958 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_619 1652-1634 108 µM -1.21044358698897 0.107352713399697 no 3032 0.113054362614436 988 5400454
SGTC_899 1083-0020 478 µM -1.21226500422664 0.107005449234547 no 3033 0.112705477704899 989 767123
SGTC_2504 purpurogallin 52.29 µM -1.21545884087596 0.106398482492001 no 3034 0.112095568885864 970 5281571 An antioxidant.
SGTC_2650 prasterone 100 µM -1.21966989729461 0.105602005379658 no 3035 0.111295018756664 968 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1152 3909-8331 15.9 µM -1.22110618399378 0.105331335315938 no 3036 0.111022909298547 964 16001939
SGTC_1521 st012942 49.4 µM -1.22260970707944 0.105048532532173 no 3037 0.110738572498661 965 24207259
SGTC_2330 7979373 200 µM -1.22302882837657 0.104969796620838 no 3038 0.110659404009174 965 1863007
SGTC_1193 1488-0126 41.5 µM -1.22396933555769 0.10479326893719 no 3039 0.110481897768421 958 1384710
SGTC_1623 st003709 20.3 µM -1.22777657905115 0.104080868125124 no 3040 0.109765425006943 961 16192618
SGTC_1418 3966-3099 2.4 µM -1.2278612614663 0.104065062604808 no 3041 0.109749526904114 962 740335
SGTC_798 1287-0182 476 µM -1.22891851139096 0.103867879032301 no 3042 0.109551180099092 1004 1649755
SGTC_389 tpck 16.7 µM -1.22896931969676 0.103858409801875 no 3043 0.109541654624608 994 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1812 st052057 4.327 µM -1.22945626960886 0.103767687874172 no 3044 0.109450392058618 987 3645418
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.22986975046498 0.103690698851834 no 3045 0.109372941705392 996 4174840
SGTC_2638 epoxomicin 18 µM -1.22993304051602 0.103678918072912 no 3046 0.109361090128962 968 9915668 A protesome inhibitor.
SGTC_2351 9026858 72.31 µM -1.23236433925921 0.103227092270829 no 3047 0.108906507862619 1009 1409300
SGTC_1930 st074634 34.3 µM -1.23264435841841 0.103175146247097 no 3048 0.10885423977476 978 684253 YOR116C RPO31
SGTC_2187 6125751 200 µM -1.23341327831786 0.103032602460175 no 3049 0.108710806743053 997 874498
SGTC_1048 3161-0300 24.5 µM -1.23563158863253 0.102622169758409 no 3050 0.108297768651358 971 2165101
SGTC_1671 st016596 74.5 µM -1.23591641092445 0.10256955803192 no 3051 0.108244818113599 991 2829167
SGTC_2026 5148700 152 µM -1.23748611721906 0.102279957236573 no 3052 0.107953332596584 987 79838
SGTC_987 1497-1013 404 µM -1.23751386758073 0.102274842827257 no 3053 0.107948184602067 990 1676435
SGTC_273 hydroxyurea 18.1 mM -1.237744640224 0.102232318487369 no 3054 0.107905380609586 997 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3045 9092950 49.47 µM -1.23846882506836 0.102098956876669 no 3055 0.107771137285133 983 44120432
SGTC_19 0279-0214 38.434 µM -1.24147558203855 0.101546603930402 no 3056 0.107215056547736 983 3566274 YBR002C RER2
SGTC_3178 9107506 49.47 µM -1.24176584769469 0.101493396406639 no 3057 0.107161483450318 976 8897194
SGTC_2558 carylophyllene oxide 100 µM -1.24227631704564 0.10139987341781 no 3058 0.107067315123974 988 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2927 9011802 47.9 µM -1.24305973313295 0.101256466036813 no 3059 0.106922911326172 980 43912568
SGTC_1440 4100-1550 40 µM -1.24408610016846 0.101068809239631 no 3060 0.106733938091896 995 742806
SGTC_3132 9126706 49.47 µM -1.24802887986984 0.100350284616312 no 3061 0.106010240617472 969 850858
SGTC_803 4488-1585 147 µM -1.24839813077249 0.100283184435088 no 3062 0.105942646608227 964 747204
SGTC_1249 0481-0015 10.2 µM -1.24933435759031 0.100113200320992 no 3063 0.105771403229307 966 4227577
SGTC_2886 9058944 51.95 µM -1.25098420239574 0.0998141617676368 no 3064 0.105470120560493 966 4949929
SGTC_884 0851-0618 334 µM -1.25265620229247 0.0995117737634784 no 3065 0.105165425841131 972 9642473
SGTC_770 0389-1121 67.2 µM -1.25387296329769 0.0992921388535199 no 3066 0.104944091782402 982 6753108
SGTC_881 0833-0569 170 µM -1.25721242266942 0.0986911618822446 no 3067 0.104338363070451 991 5418700
SGTC_1004 4084-0029 199 µM -1.26172915075697 0.0978825624227075 no 3068 0.103523131857305 990 716894 YLR208W SEC13
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.26387220252689 0.097500609256174 no 3069 0.10313795023897 975 688664
SGTC_1424 4048-1941 275 µM -1.26669102309722 0.0969998808075274 no 3070 0.102632895546735 980 X1424
SGTC_2402 5553605 200 µM -1.26793876337843 0.0967788389775574 no 3071 0.102409909899756 1006 6758546
SGTC_2989 9073649 71.4286 µM -1.26804234224509 0.0967605062375615 no 3072 0.102391415004437 984 21367202
SGTC_173 1273-0061 2.693 µM -1.26870188831975 0.0966438309823705 no 3073 0.102273704365654 956 2847414 YPL266W DIM1
SGTC_1653 st012112 65 µM -1.26900273690075 0.0965906444923554 no 3074 0.102220043957112 983 720429
SGTC_3352 9151559 45.5865 µM -1.26989216075376 0.0964335305724022 no 3075 0.102061522973827 974 17159339
SGTC_343 4130-2827 29.8 µM -1.27160400200376 0.0961316678809842 no 3076 0.101756927060668 997 1118244
SGTC_1749 st037932 54.2 µM -1.27228205963994 0.0960122928155329 no 3077 0.101636460255976 999 594497
SGTC_2628 lathosterol 100 µM -1.27245644590668 0.0959816089666571 no 3078 0.101605494793414 987 6710616
SGTC_3020 9089140 49.47 µM -1.27276211764645 0.0959278423971638 no 3079 0.101551233776016 1009 17217859
SGTC_3058 9093861 49.47 µM -1.2779509266273 0.0950185262306393 no 3080 0.100633364934047 974 17217477
SGTC_2900 5328528 85.29 µM -1.27854541126055 0.0949147521477463 no 3081 0.100528591824253 993 795359
SGTC_2027 5150920 200 µM -1.27884102192637 0.0948631810239335 no 3082 0.100476522469853 959 786715
SGTC_151 3013-0144 2.285 µM -1.28449588932547 0.0938806256998969 no 3083 0.0994842504851262 982 906558 YHR107C CDC12
SGTC_2823 7987624 58.44 µM -1.28601967855669 0.0936171506055985 no 3084 0.0992180969954482 995 2239440
SGTC_3166 9102297 49.47 µM -1.28622409815579 0.0935818464342894 no 3085 0.0991824315804442 984 25237072
SGTC_72 0744-0168 198.391 µM -1.28627131420223 0.0935736934115431 no 3086 0.0991741950541592 1009 677577
SGTC_2114 5491910 81.25 µM -1.28850927215744 0.0931878558062979 no 3087 0.098784371651679 989 2849228
SGTC_2200 6600604 21.907 µM -1.2886960213772 0.0931557123249951 no 3088 0.0987518931064953 1007 2904777
SGTC_1934 st074720 32.6 µM -1.290982035015 0.0927629049590054 no 3089 0.0983549535326727 975 17250992
SGTC_1231 0242-0792 125 µM -1.29121966557042 0.0927221431162717 no 3090 0.0983137589011492 994 3707635
SGTC_956 1185-0240 191 µM -1.29748759103469 0.0916517552179269 no 3091 0.0972317359978994 989 1416193
SGTC_2539 epi(13)torulosol 80 µM -1.29817933294576 0.0915341881551662 no 3092 0.0971128590914613 975 6708597
SGTC_2951 9072950 58.06 µM -1.2993973001953 0.0913274565910881 no 3093 0.0969038088688211 974 16488155
SGTC_1992 st073643 23.3 µM -1.30138718164175 0.0909904492884739 no 3094 0.0965629795120594 1000 3161292
SGTC_2043 5101342 149 µM -1.30194451756708 0.0908962241779374 no 3095 0.0964676763834253 1005 678451
SGTC_3116 9124943 49.47 µM -1.3032615676536 0.0906738469018629 no 3096 0.0962427385865523 968 41905195 YPL160W CDC60
SGTC_1524 corynanthine 62.1 µM -1.30349625423173 0.0906342636774317 no 3097 0.09620269717972 1006 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2041 5107442 45.335 µM -1.30617697626696 0.0901830314759367 no 3098 0.0957461902708868 993 793005
SGTC_3199 9111318 49.47 µM -1.30625305260884 0.0901702503306749 no 3099 0.0957332583341279 969 8548020
SGTC_218 alverine citrate 93.75 µM -1.31232673828714 0.0891541825111144 no 3100 0.0947049570870238 990 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2327 6189656 200 µM -1.31262231864587 0.0891049531291438 no 3101 0.0946551225869412 998 5349088
SGTC_2506 ethyl hematommate 54.16 µM -1.31894881812379 0.0880561096406627 no 3102 0.0935931119555456 993 3940691 An allergen.
SGTC_1500 4488-1866 171 µM -1.3209051554426 0.0877336474159881 no 3103 0.093266495276146 1002 2900003
SGTC_1664 st014217 9.02 µM -1.3218130482855 0.087584299452127 no 3104 0.0931152061253611 971 3982782
SGTC_1335 1486-0900 202 µM -1.32200026345088 0.0875535262486486 no 3105 0.0930840315946859 990 X1335
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.32575372836071 0.0869382576139118 no 3106 0.0924606421553327 983 23665772 A membrane-active detergent.
SGTC_2703 st077852 53.4 µM -1.33100996893473 0.0860820902444097 no 3107 0.0915928653807062 982 6281836
SGTC_1977 st070720 65.3 µM -1.33485842562512 0.08545924222756 no 3108 0.0909613434644611 986 682188
SGTC_945 3381-0768 11.3 µM -1.33516993612537 0.0854089742979983 no 3109 0.0909103670489534 1004 1126236 YIL048W NEO1
SGTC_3068 9116768 49.47 µM -1.33564728789874 0.085331987815405 no 3110 0.0908322930498674 995 41904888
SGTC_2452 5863136 48.41 µM -1.33666532932406 0.0851679735003686 no 3111 0.0906659519415614 992 2184096
SGTC_2508 celastrol 40.54 µM -1.33866334540382 0.0848467646641459 no 3112 0.0903401470645269 956 122724 Celastrol is a natural product and antioxidant.
SGTC_1160 4092-0570 10.5 µM -1.34008227089849 0.084619204827523 no 3113 0.0901092996511628 1010 4994975
SGTC_761 k216-0224 480 µM -1.34735001849968 0.0834608140981081 no 3114 0.0889337649328625 1030 1340404
SGTC_3309 9129340 25.759 µM -1.35038458754197 0.0829806831107708 no 3115 0.0884463260188052 998 17158987
SGTC_2289 7946404 165.07 µM -1.35181554094756 0.0827549990997377 no 3116 0.0882171656489007 980 1246120 YPR165W RHO1
SGTC_1768 st044301 37.178 µM -1.3526965645898 0.0826162776310123 no 3117 0.0880762942036426 1025 3931349
SGTC_487 nimodipine 119 µM -1.35468335752427 0.0823040898804458 no 3118 0.0877592312407162 1031 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2210 7115885 190.385 µM -1.35621249309469 0.0820644201445962 no 3119 0.0875157840903571 1017 2927039
SGTC_1446 4239-0190 62 µM -1.35632808805895 0.0820463237158313 no 3120 0.0874974012193005 1018 1340085
SGTC_370 0180-0345 38.7 µM -1.35845109339762 0.0817145009943661 no 3121 0.087160295580026 972 3989527
SGTC_3249 9135183 49.47 µM -1.36205549344367 0.0811534567196809 no 3122 0.086590186318652 964 4902779
SGTC_3355 9151058 44.0485 µM -1.36465544070217 0.0807505689389604 no 3123 0.0861806854262744 1013 17015728
SGTC_863 0466-0191 129 µM -1.36738804989505 0.0803287536869072 no 3124 0.0857518530068182 1007 765160 YPR165W RHO1
SGTC_720 r052-1644 49.9 µM -1.36773959495128 0.0802746090488171 no 3125 0.085696800689732 1004 1422863 YOR257W CDC31
SGTC_2235 salicylic acid 500 µM -1.36875594050954 0.0801182276001329 no 3126 0.085537788762398 1011 338 A COX inhibitor and kinase inhibitor.
SGTC_1303 1160-0052 261 µM -1.37102116247577 0.07977051478729 no 3127 0.0851841795569582 983 3562476
SGTC_440 fluspirilene 35.1 µM -1.37497930387717 0.0791656795354285 no 3128 0.0845689305498697 1015 3396 An atypical antipsychotic.
SGTC_624 k048-0052 28 µM -1.37680231816147 0.0788882792875081 no 3129 0.0842866869750042 1016 6835531
SGTC_1685 st024049 53.0905 µM -1.37916548864053 0.0785297825439486 no 3130 0.083921867998163 999 1941139
SGTC_516 3992-2719 87.3 µM -1.37922421721235 0.0785208890782041 no 3131 0.0839128167868341 1022 5350887 YDR037W KRS1
SGTC_2717 st081029 62.2815 µM -1.38018858289666 0.0783749611100102 no 3132 0.0837642941787142 991 5292846
SGTC_404 fumagillin 50 µM -1.38077668392536 0.078286070562125 no 3133 0.0836738173230093 990 12015870 A methionine aminopeptidase binder.
SGTC_1062 mesoridazine 14.2 µM -1.38332689352886 0.0779014947891454 no 3134 0.0832823277145185 991 4078 A neuroleptic.
SGTC_2082 5219693 150 µM -1.38682826184705 0.0773758203729974 no 3135 0.0827470685191105 997 2834649
SGTC_97 0535-0701 19.132 µM -1.38851364657378 0.0771237494095677 no 3136 0.0824903461105112 971 2832013 YGL099W LSG1
SGTC_3089 9117425 49.47 µM -1.39519470718645 0.0761306477216258 no 3137 0.0814785663346465 1016 9401657
SGTC_2382 9035899 200 µM -1.40034517242373 0.0753717279921744 no 3138 0.0807049899279645 1016 6462679
SGTC_2819 7996655 46.38 µM -1.4007091058828 0.0753183214005556 no 3139 0.0806505392998716 988 6456960
SGTC_1324 1418-0026 34.4 µM -1.40461779261583 0.0747465458342582 no 3140 0.0800674814383109 1023 1372513
SGTC_3281 9140613 49.47 µM -1.40587490275957 0.0745633572841678 no 3141 0.0798806375005153 977 16013766
SGTC_1351 1496-0003 46.5 µM -1.40813516915626 0.0742348490924919 no 3142 0.0795455244129472 1022 3891978
SGTC_1759 st043059 70 µM -1.40818147041622 0.0742281312175223 no 3143 0.0795386708016237 1004 669426
SGTC_1437 4092-1038 11.6 µM -1.41496826019343 0.0732484453485841 no 3144 0.078538901160691 1010 3977136
SGTC_609 0986-0026 86.3 µM -1.41729617333731 0.0729146949316616 no 3145 0.0781981767519668 989 2848610
SGTC_116 0155-0182 31.788 µM -1.42186618119558 0.0722628851441385 no 3146 0.077532551255853 901 771486
SGTC_1836 st055642 81 µM -1.42403157485993 0.0719556034292592 no 3147 0.077218666039116 1004 8571
SGTC_185 k048-0037 25.491 µM -1.42454674511113 0.0718826455783859 no 3148 0.0771441317628684 1013 6827589
SGTC_1162 k048-0130 20.1 µM -1.42576892416899 0.0717097888483387 no 3149 0.076967526910982 1004 6797406
SGTC_1299 1079-1439 3.74 µM -1.43281159321877 0.0707199277526842 no 3150 0.0759558436638893 1017 323161
SGTC_2784 7567673 72.73 µM -1.43652897516993 0.0702016934932523 no 3151 0.0754259387477746 988 3471247
SGTC_1621 st003705 32.4 µM -1.44506029750867 0.0690234031961957 no 3152 0.0742204748031498 1005 24207032
SGTC_1300 1094-0077 113 µM -1.44785840677491 0.0686402842771573 no 3153 0.0738283270459398 1022 5532636
SGTC_2263 7948595 193.29 µM -1.45727868064449 0.0673625024474593 no 3154 0.0725197346597109 1003 2971371
SGTC_223 busulfan 5 mM -1.45743688893656 0.0673412008787942 no 3155 0.072497910271264 1016 2478 A DNA alkylator.
SGTC_295 k015-0027 31 µM -1.45872729846695 0.067167651229349 no 3156 0.0723200897451588 1022 3887424
SGTC_664 1222-0054 14.9 µM -1.45946905399628 0.0670680477585611 no 3157 0.0722180260110532 1018 6813991
SGTC_1123 mangostin 811.285 nM -1.46041991870239 0.066940532073239 no 3158 0.0720873508776646 978 5281650 An antioxidant.
SGTC_1573 oleylamine 1.06 µM -1.46194372128506 0.0667365737610394 no 3159 0.0718783163149788 998 5356789 An amine of the fatty acid oleic acid.
SGTC_1849 st056239 19.2 µM -1.46436609134784 0.0664133340237661 no 3160 0.0715469739054849 1004 5393181
SGTC_2648 atorvastatin 78.68 µM -1.47581643033781 0.0649017895803322 no 3161 0.0699965893690642 1015 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.47931659357101 0.0644451072083448 no 3162 0.0695278600033063 989 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_342 k048-0088 23.3 µM -1.48178262220319 0.0641248551321336 no 3163 0.0691990722247766 1019 6820570
SGTC_1530 rhein 70.4 µM -1.48429573358258 0.0637997628662578 no 3164 0.0688652408369348 1020 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2150 5556613 200 µM -1.48644380400215 0.0635229091767512 no 3165 0.0685808853236686 1026 743190
SGTC_1178 0988-0033 191 µM -1.48957951352993 0.0631204434765483 no 3166 0.0681674159820805 1007 5392207
SGTC_2963 9082507 9 µM -1.4898581996387 0.0630847706527149 no 3167 0.0681307622070502 1032 16459611
SGTC_2312 7706453 155.7 µM -1.49258338383663 0.0627367642594181 no 3168 0.0677731377543483 1026 976098
SGTC_35 0133-0054 64.071 µM -1.49419684855031 0.0625314307936359 no 3169 0.0675620880392102 1013 99677
SGTC_24 0417-1663 219 µM -1.50653759040072 0.0609782022208461 no 3170 0.0659646124233219 1045 4329390
SGTC_2053 5265679 138 µM -1.50922756305971 0.0606436748355202 no 3171 0.0656203193586707 997 764595
SGTC_1404 3909-7820 48.3 µM -1.51415899583929 0.0600341275069067 no 3172 0.0649927593278969 976 23741373
SGTC_1420 4'-methoxyflavone 42 µM -1.51538299677197 0.0598835811376404 no 3173 0.0648377204071412 1017 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_506 n9-isopropylolomoucine 153 µM -1.51581669511409 0.0598303092840794 no 3174 0.0647828546589865 1022 6610355
SGTC_786 4544-0069 423 µM -1.52051074561147 0.0592561041664828 no 3175 0.064191330067092 1008 748821 YLR208W SEC13
SGTC_2329 6138490 200 µM -1.52870424960611 0.058264188832936 no 3176 0.063168889169739 1031 720019
SGTC_1106 tegaserod maleate 11.7 µM -1.52953842974708 0.0581639379354041 no 3177 0.0630655098597468 1003 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3234 9132280 49.47 µM -1.53397813748102 0.0576326568253018 no 3178 0.0625175156721342 1014 17612295
SGTC_2679 rapamycin 1 nM -1.53875513376617 0.0570652840452907 no 3179 0.0619320434279932 968 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3284 9108171 64.8615 µM -1.55164779516473 0.0555559348696971 no 3180 0.0603732601606718 1004 8687505
SGTC_527 4476-4215 268 µM -1.55896769691778 0.0547131210003972 no 3181 0.0595020129788606 1015 4418754
SGTC_1275 0867-0008 21.1 µM -1.56622542941473 0.0538874773525569 no 3182 0.0586479257311277 1041 3422836
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.56796933965625 0.0536905665332062 no 3183 0.0584441439581226 1039 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1761 st044296 37 µM -1.57429906352635 0.0529806404093495 no 3184 0.0577091630891316 1036 1826700
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.57487897965748 0.0529159724921061 no 3185 0.0576421907499807 1020 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_663 1486-0733 13.9 µM -1.57721948923906 0.0526556123582755 no 3186 0.0573725150393626 1033 722445 YPR165W RHO1
SGTC_2423 st077119 87.2 µM -1.57792527861886 0.0525772996014058 no 3187 0.0572913884271092 1020 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_439 amiodarone 34.4 µM -1.58046437715584 0.0522963313126855 no 3188 0.0570002793285091 1018 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_797 k781-0471 270 µM -1.58129962677525 0.0522041663903616 no 3189 0.0569047724583366 1005 23738129
SGTC_1919 st067113 52.3 µM -1.58586936722005 0.0517022036377959 no 3190 0.056384472995468 1025 1268243
SGTC_1291 0993-0025 5.79 µM -1.59561947520545 0.0506440322892505 no 3191 0.0552868883567707 1034 4353356
SGTC_518 1021-0119 62.6 µM -1.59562975534024 0.0506429257673931 no 3192 0.0552857400759531 1021 1097762
SGTC_1597 7-benzyloxygramine 47.5 µM -1.59991428607248 0.0501834260555455 no 3193 0.0548087998118975 1010 260807
SGTC_3004 9076122 71.4286 µM -1.6022634781674 0.0499328983625353 no 3194 0.0545486791049634 1032 44782551
SGTC_1165 k072-0275 30.3 µM -1.60456334168228 0.0496885985293836 no 3195 0.0542949671494127 1033 6153523 YGL055W OLE1
SGTC_1030 k029-0042 36.7 µM -1.61369138741082 0.0487283746040906 no 3196 0.0532971915029551 1024 6080581
SGTC_402 epigallocatechin gallate 10 µM -1.61458890015878 0.0486347672276457 no 3197 0.0531998753835131 1020 65064 An antioxidant.
SGTC_1261 0712-0010 12.7 µM -1.62199168944686 0.0478681546472249 no 3198 0.0524025637877931 1022 2840123
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.63071681981168 0.0469770576757965 no 3199 0.0514750429206494 991 688669
SGTC_2789 5281112 71.43 µM -1.63283906910418 0.0467623361965064 no 3200 0.051251423869167 1024 765948
SGTC_1845 st056753 3.01 µM -1.63306059702923 0.0467399682606721 no 3201 0.0512281263345264 1021 5375839
SGTC_1627 st003713 25.6 µM -1.63328600073371 0.0467172177938761 no 3202 0.0512044298431303 1031 16195070 YER133W GLC7
SGTC_3056 9094900 49.47 µM -1.63763816450506 0.0462796841705102 no 3203 0.0507485984014225 1039 25236784
SGTC_2432 5630864 12.22 µM -1.63782673264695 0.0462608015785438 no 3204 0.0507289216635427 1034 5714970
SGTC_2584 androsterone 48.74 µM -1.63813696379456 0.046229749516014 no 3205 0.0506965628358959 981 2754130 A steroid.
SGTC_2204 7233102 200 µM -1.63928601664425 0.0461148827930384 no 3206 0.0505768534335819 1027 2172480
SGTC_622 1348-1566 26.3 µM -1.65078198516463 0.0449782485217737 no 3207 0.0493915499571814 1038 7340407
SGTC_2199 6590217 200 µM -1.65229924126237 0.0448299328484679 no 3208 0.0492367819577741 1003 703109
SGTC_431 k089-0097 107 µM -1.6528978490603 0.0447715258344702 no 3209 0.0491758274909953 985 5499420
SGTC_528 3492-0019 172 µM -1.65618628862168 0.0444517601654857 no 3210 0.0488420495399412 1027 2869262
SGTC_2661 dactinomycin 12.96 µM -1.66158719353005 0.0439305750197323 no 3211 0.0482977864341166 1040 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1667 st014849 34.6 µM -1.67421105719123 0.0427315897683366 no 3212 0.0470445635801615 1031 5348460
SGTC_1909 st060837 51.5 µM -1.67489814899046 0.0426670980187403 no 3213 0.0469771084357628 1012 678937
SGTC_2983 9022671 12.99 µM -1.67583086851772 0.0425796771198359 no 3214 0.0468856629550517 1032 6405161
SGTC_2713 st079149 53.4 µM -1.68281309557198 0.0419298458118741 no 3215 0.0462056395536455 1043 3103253
SGTC_2424 5537928 59.2 µM -1.68457546530717 0.0417670986356415 no 3216 0.0460352541226138 1020 5382802
SGTC_922 1866-0035 480 µM -1.68751421068899 0.041496856360073 no 3217 0.0457522598779958 1008 3156169
SGTC_1016 4226-1401 38 µM -1.69988758585483 0.0403745223582466 no 3218 0.0445760362154412 1039 2901613
SGTC_679 0422-0091 41.4 µM -1.70448780746123 0.0399635943865288 no 3219 0.0441449959887409 1048 627384 YHR062C RPP1
SGTC_142 0335-0849 62.6745 µM -1.70762173774985 0.039685598506405 no 3220 0.0438532761211567 1021 3889043 YPR107C YTH1
SGTC_2418 pentamidine 31.67 µM -1.71052245569023 0.0394296929941651 no 3221 0.0435846522976293 986 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1513 0337-0559 19 µM -1.71683324989847 0.0388775821678874 no 3222 0.0430048219239318 1037 775073
SGTC_2884 9058502 51.95 µM -1.71696358548586 0.0388662462336955 no 3223 0.0429929128104531 1040 6471554
SGTC_1491 4138-0063 26.5 µM -1.71840830488491 0.0387407720138501 no 3224 0.0428610832964188 1056 23883227
SGTC_3235 9132602 49.47 µM -1.71847534883583 0.0387349572523465 no 3225 0.0428549735290463 1042 4912240
SGTC_1076 itraconazole 331 nM -1.72270774666408 0.0383693156171845 no 3226 0.0424706943693509 1051 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_745 0469-0705 296 µM -1.73099064682646 0.0376618885826408 no 3227 0.0417267163387793 1043 3486736
SGTC_3047 9092122 49.47 µM -1.73141282466766 0.0376261182655545 no 3228 0.0416890804378576 1038 17173831
SGTC_1286 0929-0070 131 µM -1.73793364519919 0.037077136074274 no 3229 0.0411112532126195 1048 1420408
SGTC_2412 st077135 33.4 µM -1.73882429489432 0.0370026637728917 no 3230 0.0410328368978057 1048 13258915
SGTC_751 0833-0568 350 µM -1.74148165887644 0.036781192789474 no 3231 0.0407995927386421 1058 6954252
SGTC_3236 9132701 49.47 µM -1.74801997422495 0.0362408864933108 no 3232 0.0402302843782327 1057 24282524
SGTC_2827 7993847 71.43 µM -1.74922056724491 0.0361423827955065 no 3233 0.0401264501091268 1032 2985692
SGTC_2060 5238662 140 µM -1.76376356028107 0.0349665112052917 no 3234 0.0388858974699591 1050 790130
SGTC_2192 5915882 198.485 µM -1.78094931642806 0.0336176280378966 no 3235 0.0374603655027595 1052 2876149
SGTC_20 0481-0013 4.944 µM -1.78343823907971 0.0334258743736541 no 3236 0.037257496609662 1049 182045
SGTC_859 0439-0102 54.6 µM -1.7850685807786 0.0333007570474755 no 3237 0.0371250967615574 1041 610143
SGTC_1194 1488-0194 225 µM -1.78821247353738 0.033060574258452 no 3238 0.0368708673063726 1059 1391452
SGTC_1636 st007707 68.9 µM -1.80104243324502 0.0320951618415914 no 3239 0.0358480960231102 1046 403051
SGTC_2212 7123476 200 µM -1.80372274405659 0.0318964449591978 no 3240 0.0356373911006 1062 1085715
SGTC_2476 5806916 10.51 µM -1.80625494404468 0.031709643542108 no 3241 0.0354392630640663 1024 2870194
SGTC_728 3030-5151 22.5 µM -1.81011000981958 0.0314269901612291 no 3242 0.0351393645037217 1063 3125388
SGTC_3043 9092303 49.47 µM -1.81078366583073 0.0313778121559477 no 3243 0.035087172868096 1042 25236084
SGTC_1355 1499-0035 1.68 µM -1.82823060406488 0.0301261576132483 no 3244 0.0337574748815257 1059 1548538
SGTC_154 3389-1638 511.116 µM -1.82936095023263 0.0300465142846307 no 3245 0.0336727767279124 1057 5238686
SGTC_2286 7945697 125 µM -1.83583946146567 0.0295934042353315 no 3246 0.0331907016578668 1041 1245733
SGTC_601 0986-0029 62.9 µM -1.84377992477901 0.0290457944580489 no 3247 0.0326076097717328 1031 24747981
SGTC_452 diindolylmethane 8 µM -1.85371367261879 0.0283726009443572 no 3248 0.0318900672877215 1056 3071 Inhibits expression of several cancer promoting factors.
SGTC_377 3970-0964 33.1 µM -1.86257485105629 0.0277830986715613 no 3249 0.03126105267786 1061 16481235
SGTC_2400 5203494 178.7 µM -1.87382294965429 0.0270495366509015 no 3250 0.0304774160655785 1036 6777674
SGTC_867 0518-0118 155 µM -1.87620912954961 0.0268960145954534 no 3251 0.0303132844753957 1044 6848158
SGTC_3270 9137563 49.47 µM -1.88808746566693 0.0261425697211595 no 3252 0.0295071046449593 1043 17015724
SGTC_1284 0929-0043 16 µM -1.8885424351442 0.0261140654918173 no 3253 0.0294765833343921 1057 1239883
SGTC_3170 9103054 49.47 µM -1.89389534361931 0.0257806486298177 no 3254 0.0291194513449681 1035 16432970
SGTC_492 tmb-8 126 µM -1.89591866941215 0.0256555529363563 no 3255 0.02898539991988 1070 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_21 0849-0113 22.993 µM -1.89750162273752 0.0255580386935542 no 3256 0.0288808824092291 1066 1560156
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.89826678132542 0.0255110142146867 no 3257 0.0288304737774996 1035 6708739 YPR165W RHO1
SGTC_2639 lactacystin 53 µM -1.89995484338339 0.0254075269059584 no 3258 0.0287195229313045 1039 3870 A proteasome inhibitor.
SGTC_1990 st072050 59.8 µM -1.90028544392104 0.0253873005411279 no 3259 0.0286978352588337 1061 17233948
SGTC_1065 prochlorperazine maleate 2.48 µM -1.90516074893258 0.0250905887602212 no 3260 0.0283795893382799 1062 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2737 bleomycin 30.5 nM -1.90916915078035 0.0248488192949705 no 3261 0.028120137248989 1064 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1511 0906-3109 28.5 µM -1.9169263310653 0.0243864871047083 no 3262 0.0276236456873315 1063 2882180
SGTC_2949 9072542 2.23 µM -1.92782160206625 0.0237493353598324 no 3263 0.0269386599022564 1058 16457352
SGTC_1615 st002656 86.5 µM -1.93186854621054 0.0235162637961879 no 3264 0.0266878664593234 1071 1584458
SGTC_1283 0922-0125 16.4 µM -1.93190614010721 0.0235141077417454 no 3265 0.0266855458986449 1046 3360884
SGTC_3240 9133527 49.47 µM -1.93920623416732 0.0230985784106957 no 3266 0.0262381154067637 1060 17617455
SGTC_700 3453-2283 142 µM -1.9397460583885 0.0230680980915352 no 3267 0.0262052795468063 1053 565664
SGTC_3348 9149464 3.537 µM -1.94847439730838 0.0225799487384127 no 3268 0.0256791127013779 1057 1951442
SGTC_1614 st002383 48.6 µM -1.9608237216762 0.0219041880533166 no 3269 0.0249497949202614 1074 1947235
SGTC_872 0588-0139 234 µM -1.96433359727159 0.0217152717525105 no 3270 0.0247457089544341 1064 2047100
SGTC_55 0767-0285 6.563 µM -1.96764282066563 0.0215384179156228 no 3271 0.0245545745685044 1051 3116166
SGTC_618 k072-0232 33.2 µM -1.97324210563782 0.0212419495950472 no 3272 0.0242339927052819 1036 5872756 YGL099W LSG1
SGTC_1675 st018485 24.5 µM -1.97558776734096 0.0211187823336222 no 3273 0.0241007426100429 1059 3323024
SGTC_3031 9088762 49.47 µM -1.97818747102596 0.0209829821284142 no 3274 0.023953780807482 1065 205253
SGTC_263 alizarin 107.927 µM -1.97840416199415 0.0209716963272657 no 3275 0.0239415652965449 1058 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2851 9015922 71.43 µM -1.98081787709303 0.0208463310238138 no 3276 0.0238058506281423 1060 2996893
SGTC_465 cgp-37157 41 µM -1.98494693198561 0.0206333441082206 no 3277 0.0235751880240264 1071 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1612 st002233 45.4 µM -1.98764747558441 0.0204950426555873 no 3278 0.0234253458696993 1051 1035021
SGTC_1338 1486-1223 76 µM -1.99315564616719 0.0202153894464074 no 3279 0.0231222031085487 1052 3444526
SGTC_3231 9132313 49.47 µM -2.00257317598155 0.0197447502489761 no 3280 0.0226115607170431 1071 4905967
SGTC_1949 st076024 69.1 µM -2.00272888506657 0.0197370475523735 no 3281 0.0226031983182625 1064 2921930
SGTC_432 NS 1619 61.3 µM -2.00478206718792 0.0196357180366085 no 3282 0.0224931752433996 1049 4552 A K+/calcium channel activator.
SGTC_145 3737-0113 38.366 µM -2.00766641125199 0.0194941150510482 no 3283 0.0223393761044365 1058 6849351
SGTC_1005 4092-0690 4.4 µM -2.00951261540241 0.0194039341806358 no 3284 0.0222413990825275 1066 1529343
SGTC_866 0495-0101 262 µM -2.00986595356414 0.0193867152679745 no 3285 0.0222226890189909 1040 635694
SGTC_844 0330-0132 15.3 µM -2.02017879223954 0.0188898378343687 no 3286 0.0216824226369538 1067 2828079
SGTC_697 0508-1955 564 µM -2.03150043782389 0.0183568717000777 no 3287 0.02110212758609 1062 6243113
SGTC_3180 9109287 49.47 µM -2.03272928495434 0.0182998019610787 no 3288 0.0210399404616793 1043 18891271
SGTC_1031 k035-0009 16 µM -2.04506059664095 0.0177354367232953 no 3289 0.0204244421811951 1076 5180959
SGTC_926 2268-1401 59.4 µM -2.06037907550905 0.017055100096814 no 3290 0.0196811578345647 1066 2931578
SGTC_2028 5153890 36.43 µM -2.06426111772239 0.0168862735966253 no 3291 0.019496482736047 1072 2830968 YPR165W RHO1
SGTC_908 3448-7491 47.7 µM -2.0676226440474 0.0167412403751052 no 3292 0.0193377605381428 1026 1203031
SGTC_1272 0839-0021 27 µM -2.13367728219555 0.01410016654822 no 3293 0.0164346034737573 1079 5027250
SGTC_2555 cholic acid 100 µM -2.13545175820488 0.0140344763987744 no 3294 0.016362063371737 1067 6708657 Influences liver metabolism.
SGTC_2601 securinine 100 µM -2.14672648785133 0.0136232234425407 no 3295 0.0159075313705797 1056 442872 A GABA receptor antagonist.
SGTC_2176 5809774 33.9695 µM -2.1473220246684 0.013601793055459 no 3296 0.0158838267935285 1051 2870539
SGTC_2995 9067767 71.4286 µM -2.14958085078167 0.0135207734538838 no 3297 0.0157941922313868 1067 11673567
SGTC_2888 9058547 12.99 µM -2.16316446701691 0.0130422882029725 no 3298 0.0152642660786391 1062 16476514
SGTC_2325 6158266 200 µM -2.1783363320518 0.0125252282318361 no 3299 0.0146905030734195 1063 3623240
SGTC_3007 9078383 71.4286 µM -2.18476070034034 0.0123116908699713 no 3300 0.0144531984726683 1080 6496995
SGTC_2178 5812956 200 µM -2.19623290474059 0.0119382084158104 no 3301 0.0140376386611629 1068 5403383
SGTC_2347 9049783 174.81 µM -2.20749333114872 0.0115812169992295 no 3302 0.0136398061968895 1073 6467988 YPL169C MEX67
SGTC_2055 5235184 200 µM -2.2145166929189 0.0113632790924404 no 3303 0.0133966278421198 1064 2836034
SGTC_2122 5258151 111.688 µM -2.21898541919254 0.0112264752825682 no 3304 0.0132438582582853 1076 2173356
SGTC_212 3807-4682 38.772 µM -2.22481668161989 0.0110501140036423 no 3305 0.0130467735354525 1074 3125501 YBL034C STU1
SGTC_2127 5253358 187.912 µM -2.22656933663334 0.0109975797271482 no 3306 0.01298803509619 1076 20612
SGTC_2852 9023854 51.95 µM -2.22999036941222 0.0108956629991108 no 3307 0.0128740411190012 1065 19798528
SGTC_294 k038-0071 157 µM -2.23266019260053 0.0108166977041626 no 3308 0.0127856807176064 1083 24152826
SGTC_2859 9028643 45.46 µM -2.27411279943718 0.00965305887154893 no 3309 0.011479602663017 1062 17151580
SGTC_1980 st071811 45.7 µM -2.27467979146846 0.00963793215282723 no 3310 0.0114625728158934 1078 4974850
SGTC_187 1488-2104 32.728 µM -2.29134418515154 0.00920250084303105 no 3311 0.0109717574883939 1074 2852859
SGTC_2667 digitoxin 100 µM -2.29518651249348 0.00910458060986324 no 3312 0.0108612189031978 1082 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3303 9125618 40.5795 µM -2.31097933801288 0.00871162427824926 no 3313 0.0104169980968428 1067 22695467
SGTC_2831 7999036 19.48 µM -2.31194969258682 0.00868797237055385 no 3314 0.0103902279035159 1077 2988270
SGTC_951 1171-0579 82.7 µM -2.31927382575214 0.00851125967403502 no 3315 0.0101900968549992 1060 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3114 9122766 49.47 µM -2.3384433589925 0.00806359604730057 no 3316 0.00968213034971699 1072 17176985
SGTC_2262 9014885 67.46 µM -2.35631723419817 0.00766497125171709 no 3317 0.00922857386531501 1088 6457424
SGTC_911 3456-4043 236 µM -2.36426759766416 0.00749330759647103 no 3318 0.00903287906850596 1079 914281
SGTC_1417 3966-0327 90.4 µM -2.3717352251416 0.00733516098861241 no 3319 0.00885238652781767 1081 651118
SGTC_1441 4106-0040 13 µM -2.41857966065486 0.00640857047267236 no 3320 0.00779061675000204 1085 2904180
SGTC_3263 9137018 49.47 µM -2.42444715834678 0.00630013610013685 no 3321 0.00766585718789439 1067 43844957
SGTC_2829 7992743 58.44 µM -2.4531157446187 0.00579334771895192 no 3322 0.00708123801385567 1079 16462845
SGTC_3159 9100096 49.47 µM -2.4664656367037 0.00556995219915964 no 3323 0.00682269103079051 1080 25236875
SGTC_3173 9105693 49.47 µM -2.47909801271879 0.00536564357785915 no 3324 0.00658575532521936 1080 17096658
SGTC_2646 retinol 96.75 µM -2.48424967871701 0.00528425477712641 no 3325 0.0064912373463244 1079 445354 A vitamin A analog and teratogen.
SGTC_1954 st077032 68.9 µM -2.489229243924 0.00520663046078337 no 3326 0.00640101942363849 1072 698907
SGTC_234 nsc-17383 10.7 µM -2.50006063909335 0.00504127856092542 no 3327 0.00620860250608947 1073 408974
SGTC_764 1951-2361 146 µM -2.54689027499578 0.0043789483105665 no 3328 0.00543438008829858 1075 5438930
SGTC_1408 3909-7976 48.8 µM -2.55624520619332 0.00425636136197794 no 3329 0.00529042642329325 1084 24152374
SGTC_3153 9100258 49.47 µM -2.55713403491465 0.00424487530671659 no 3330 0.00527692715756246 1068 25236848
SGTC_2835 9006588 71.43 µM -2.57788026375608 0.00398453400834935 no 3331 0.00497042186152157 1053 2345538
SGTC_2254 7938975 95.19 µM -2.65937611433569 0.00309476764915294 no 3332 0.00391427574086917 1087 2969277
SGTC_214 4373-3496 70 µM -2.65948418696353 0.00309371732290531 no 3333 0.00391302018225077 1088 3779166
SGTC_672 1441-0018 53.7 µM -2.665522645762 0.0030355388536893 no 3334 0.00384343771772773 1085 251141
SGTC_1372 2752-0194 270 µM -2.67243699417445 0.00297013319028228 no 3335 0.00376512570296009 1079 823334
SGTC_1436 4092-1007 8.32 µM -2.6917983430315 0.00279368915740309 no 3336 0.00355339511788187 1085 2881121
SGTC_2881 9058953 51.95 µM -2.69491232112198 0.00276621083601901 no 3337 0.00352035776463694 1076 17122249
SGTC_3050 9093513 49.47 µM -2.74192373434431 0.00237998131353295 no 3338 0.00305402608507668 1078 25236664
SGTC_1242 0402-0103 60.1 µM -2.7757082528562 0.00213330758618642 no 3339 0.00275408054102963 1084 432868
SGTC_3001 9076041 71.4286 µM -2.78467972841443 0.00207182156337893 no 3340 0.00267903087089198 1086 16004211
SGTC_1629 st005085 44.9 µM -2.80048115664499 0.00196742401842963 no 3341 0.00255132432282342 1079 24207091
SGTC_2252 omeprazole 400 µM -2.81357918665686 0.00188453417355702 no 3342 0.00244966588282659 1095 4594 A proton pump inhibitor.
SGTC_1613 st002381 52.1 µM -2.82350666705924 0.00182383743329496 no 3343 0.00237507189915636 1089 551167
SGTC_61 0978-8327 98.565 µM -2.88368938268175 0.00149240769677102 no 3344 0.00196523115922703 1082 6150059 YHR072W ERG7
SGTC_3126 9127922 49.47 µM -2.96615081363032 0.00112723559560321 no 3345 0.00150776288427119 1076 45595682
SGTC_1638 st008370 60.6 µM -2.9784633841576 0.00108035352971135 no 3346 0.00144848820489627 1078 24207134
SGTC_464 bw-b 70c 158 µM -2.97898277571134 0.00107841573351997 no 3347 0.0014460351748859 1094 5353454
SGTC_199 4063-0024 41.6 µM -3.07377566989702 0.000773635325268495 yes 3348 0.00105684152710628 1094 306215
SGTC_3343 9148379 18.9835 µM -3.08298244568804 0.00074871898194321 yes 3349 0.00102468621765487 1085 1955036
SGTC_2954 9074818 52.69 µM -3.20757548335176 0.000476762862300635 yes 3350 0.00066929463752929 1090 16648742
SGTC_943 3253-1379 105 µM -3.26669517725146 0.000382765061114986 yes 3351 0.000544053863434598 1085 668464
SGTC_2008 4012253 172 µM -3.27696212977016 0.000368311152582086 yes 3352 0.000524652210901555 1085 603940
SGTC_196 k015-0023 18.111 µM -3.35868908056557 0.000270085965610986 yes 3353 0.000391565626494236 1093 5211998
SGTC_2406 ethylparaben 405.7 µM -3.42456400140782 0.000209312881078805 yes 3354 0.000307893391506954 1091 8434 A possible steroid mimic.
SGTC_194 1486-1323 56.904 µM -3.65882213512954 8.16048469193854e-05 yes 3355 0.00012668855481257 1095 5178754
SGTC_2052 5265182 7.135 µM -3.82200584410032 4.09729301062727e-05 yes 3356 6.61852759647099e-05 1093 1239884