SGTCid condition conc unit SPC25|YER018C.score SPC25|YER018C.strain.pval SPC25|YER018C.strain.significant SPC25|YER018C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2011 4012611 177 µM 5.32245885659528 4.80306118969416e-09 yes 1 5.11869717122063e-08 4 2049887 SGTC_1255 0566-0045 221 µM 4.95506593732977 4.53930080685055e-08 yes 2 3.61528824780988e-07 10 2788469 SGTC_3253 9135987 49.47 µM 4.73557931105903 1.61667611688987e-07 yes 3 1.09215131299977e-06 2 4182430 SGTC_1637 st007924 17.4 µM 4.30400375266853 1.6813096418114e-06 yes 4 8.38694099145177e-06 3 683336 SGTC_1246 0422-0085 105 µM 4.11271317643396 4.44474455607619e-06 yes 5 1.95518050317349e-05 10 264295 SGTC_795 0685-0265 78 µM 4.03738295707576 6.44623901343936e-06 yes 6 2.70253981425725e-05 16 302754 SGTC_1631 benzylvanillin 81.9 µM 3.99526396658124 7.91410047677624e-06 yes 7 3.23111055701089e-05 6 75506 SGTC_2349 9023730 187.07 µM 3.85266769077916 1.56228321649335e-05 yes 8 5.8418954032099e-05 5 4126287 SGTC_2473 5854593 8.94 µM 3.75554169838522 2.45129207991571e-05 yes 9 8.64834793873143e-05 3 2872951 SGTC_1148 3909-7663 27.7 µM 3.74744332736524 2.54392712960834e-05 yes 10 8.93230912278729e-05 3 4084526 SGTC_876 0720-0963 56.8 µM 3.59332602482434 5.08335886679112e-05 yes 11 0.000163241832402243 9 765861 SGTC_159 3970-0959 50 µM 3.55660456086184 5.97207881843187e-05 yes 12 0.000187839497299879 24 6615653 SGTC_1264 0783-0040 158 µM 3.49183956181021 7.90650627540661e-05 yes 13 0.000239853146764532 6 2855798 SGTC_2182 6325192 200 µM 3.45446907218886 9.27679100818674e-05 yes 14 0.000275688726523962 3 736248 SGTC_1664 st014217 9.02 µM 3.23406881518551 0.000230882179818672 yes 15 0.000610200231066373 12 3982782 SGTC_2541 muurolladie-3-one 83.07 µM 3.23130686037566 0.000233457537072251 yes 16 0.000616127853030593 29 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2186 6124449 200 µM 3.13598935931669 0.000340621234910297 yes 17 0.0008563770892479 29 3834182 YLR033W RSC58 SGTC_951 1171-0579 82.7 µM 3.07754370562029 0.000427333031582236 yes 18 0.00104357114914501 39 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1527 coumarin 137 µM 2.97270148441028 0.00063599313526425 yes 19 0.00147595696702294 16 323 A hepatotoxic, DNA x-linker. SGTC_1003 4049-0218 100 µM 2.92634415867749 0.00075539537840328 yes 20 0.00171485645465509 29 295161 SGTC_1174 0739-0097 51.1 µM 2.90285890060479 0.000823470263331959 yes 21 0.00184886597559901 14 728447 SGTC_344 k064-0035 6.43 µM 2.88220497219816 0.00088795700449391 yes 22 0.00197451377069857 18 5088750 SGTC_1927 st060202 13.8 µM 2.86660511794075 0.000939706141293467 yes 23 0.00207450172995369 20 688887 SGTC_2361 9034121 116 µM 2.83221956669825 0.00106369567857765 no 24 0.0023113047204265 35 6496917 SGTC_3194 9111903 49.47 µM 2.82484379102546 0.00109217345803717 no 25 0.00236518356774374 13 17087251 SGTC_885 0865-0106 16.8 µM 2.80749234931699 0.00116194398838173 no 26 0.0024964432917544 38 2793380 SGTC_2345 9052315 157.45 µM 2.80704686081594 0.00116378789080983 no 27 0.00249989839258642 21 6469265 SGTC_2684 capsaicin 100 µM 2.80630137381509 0.0011668794993416 no 28 0.00250568988214715 16 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3072 9116419 49.47 µM 2.78696606754323 0.00124973946652286 no 29 0.00266020248698502 16 17170162 SGTC_737 1950-0117 57.9 µM 2.78607684167757 0.00125367658920383 no 30 0.00266751116237051 20 5393513 SGTC_1273 0849-0096 14.1 µM 2.76971906314528 0.00132815601898072 no 31 0.0028052330916289 20 5286025 SGTC_2455 5377712 9.75 µM 2.74972632642528 0.00142466942954964 no 32 0.00298225283950381 19 2243908 SGTC_3122 9126309 49.47 µM 2.72963344192492 0.00152807811243628 no 33 0.00317023912201777 21 17591206 SGTC_2310 7668677 200 µM 2.72498868980072 0.00155293639552543 no 34 0.00321518449034089 33 2197143 SGTC_2031 5180455 200 µM 2.66851111237459 0.00188613050866998 no 35 0.00380941290919767 12 29949 SGTC_859 0439-0102 54.6 µM 2.64438410901803 0.00204732362441419 no 36 0.00409198631793299 31 610143 SGTC_2781 5567276 71.43 µM 2.63949727294489 0.00208145720924041 no 37 0.00415145456235839 33 2853274 SGTC_1843 st055809 45.5 µM 2.61372084476499 0.00227019379653349 no 38 0.00447810902087921 25 16413835 SGTC_2413 inermin 26.06 µM 2.57329806680184 0.00259753870227454 no 39 0.00503672057335871 49 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_700 3453-2283 142 µM 2.54959818182236 0.0028087373300552 no 40 0.00539235696388067 31 565664 SGTC_3247 9135149 49.47 µM 2.54615882474798 0.00284064164937849 no 41 0.00544578104361665 54 8934436 YOR116C RPO31 SGTC_149 3970-0822 46.1 µM 2.5447575273798 0.00285373387999839 no 42 0.00546768214725738 42 3114250 YBL034C STU1 SGTC_2885 9057732 51.95 µM 2.53397338329142 0.00295632431801764 no 43 0.00563886488101561 18 6471414 SGTC_2902 5787006 60.46 µM 2.53121195192781 0.00298312304615147 no 44 0.00568345689620003 23 591003 SGTC_380 3970-0968 6 µM 2.52779940864383 0.00301654289206476 no 45 0.00573899546519847 21 2891601 SGTC_487 nimodipine 119 µM 2.49875730919427 0.0033148952250434 no 46 0.00623148144885129 9 4497 L-type voltage-gated calcium channels inhibitor SGTC_2849 9019321 12.99 µM 2.49758812541377 0.00332744365075372 no 47 0.00625206905936311 25 16489627 SGTC_2179 6298986 200 µM 2.48052863616608 0.00351545783182411 no 48 0.00655938628905438 21 738374 SGTC_3245 9134821 49.47 µM 2.48051377641912 0.00351562567883715 no 49 0.00655965970111292 31 17014901 SGTC_3345 9148410 3.559 µM 2.47716636609756 0.00355361998047951 no 50 0.00662150784613484 13 4903596 SGTC_702 1488-0190 94 µM 2.47699663108821 0.00355555631705923 no 51 0.00662465762909842 13 949357 SGTC_1104 tacrolimus 29.8 µM 2.47207156445448 0.00361215557424242 no 52 0.00671663110476427 34 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1227 3909-8010 46.6 µM 2.47060267357426 0.00362919202944877 no 53 0.00674427959820746 19 15982272 SGTC_2341 7987486 176.74 µM 2.4499139811763 0.00387692182388567 no 54 0.00714451730097914 30 1258686 SGTC_545 4218-0007 221 µM 2.42871664272597 0.00414635474565645 no 55 0.00757618473097214 34 2840508 SGTC_1295 1013-0063 9.78 µM 2.42017328404834 0.0042596011107135 no 56 0.00775655632036588 19 6826038 SGTC_1870 st057514 26.5 µM 2.41410261038818 0.00434174343015984 no 57 0.00788700968902081 32 5393161 SGTC_3339 9145883 14.936 µM 2.38681092386843 0.00472878068663835 no 58 0.00849761471807499 15 2030670 SGTC_406 estrone 100 µM 2.37867322670043 0.00484999549858278 no 59 0.00868753548901297 25 5870 A steroid. SGTC_1833 st055984 71 µM 2.36882205088547 0.00500043384685591 no 60 0.00892241845665137 19 676288 SGTC_1241 0364-0022 50.8 µM 2.36828748604016 0.00500871486736584 no 61 0.00893532182924766 38 4563895 SGTC_918 glabranin 770.725 nM 2.33241832071924 0.00559305225433575 no 62 0.00983934761608024 27 124049 Also referred to as licorice root. SGTC_1021 4476-0760 85.3 µM 2.33162558142637 0.00560662363347556 no 63 0.00986019842615273 17 746768 SGTC_1839 st053978 48 µM 2.28468308526892 0.00646426158206068 no 64 0.0111657085749776 18 3788398 SGTC_2800 7887935 81.82 µM 2.27790411499774 0.00659725760490691 no 65 0.0113661455311027 46 2961002 SGTC_2330 7979373 200 µM 2.27726873272761 0.00660984626436978 no 66 0.0113850914471468 46 1863007 SGTC_1197 1601-0112 267 µM 2.26825411050497 0.00679075246216389 no 67 0.0116568615667206 33 7350313 SGTC_1047 2043-3044 82 µM 2.26475302124584 0.00686218342150851 no 68 0.0117639198927057 50 669592 SGTC_939 1165-0479 45.3 µM 2.2637281839024 0.00688321783445455 no 69 0.0117954189646677 34 1377347 SGTC_2685 mycophenolic acid 18.85 µM 2.23894434555347 0.00740953456471101 no 70 0.0125797688000826 21 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2175 5807670 165.306 µM 2.2365735887129 0.00746169260150258 no 71 0.0126571113559648 15 241186 SGTC_612 0302-0167 22.4 µM 2.23279419572773 0.00754551045912552 no 72 0.0127812596144629 42 235821 SGTC_3145 9085516 49.47 µM 2.2186498744001 0.00786660189102116 no 73 0.0132552768293112 46 25236195 SGTC_1848 st056003 16.4 µM 2.21596113419831 0.00792898076582498 no 74 0.0133470820194274 38 146492 SGTC_1244 0416-0015 52.5 µM 2.20432408531107 0.00820400361960581 no 75 0.013750780137302 31 96201 SGTC_1907 st060210 83.7 µM 2.20027694513282 0.00830159657422174 no 76 0.013893625990126 45 688793 SGTC_446 go6976 132 µM 2.19611675417305 0.00840297681968098 no 77 0.0140417938458372 30 3501 A protein kinase C inhibitor. SGTC_675 1309-0189 238 µM 2.18874880070694 0.00858519644707975 no 78 0.0143075514412589 46 4246530 SGTC_855 0428-0020 25 µM 2.17470175025412 0.00894222310132631 no 79 0.0148262368293737 45 6812414 SGTC_1394 3474-0001 65.7 µM 2.16778722252774 0.00912269552415472 no 80 0.015087439729654 23 5017666 YIL048W NEO1 SGTC_3342 9147791 14.508 µM 2.1675763891196 0.00912824811874699 no 81 0.0150954659004722 27 1838168 SGTC_1362 1611-0397 101 µM 2.16365009580179 0.00923219456764907 no 82 0.0152456068569346 46 27816 SGTC_1999 st074831 12.5 µM 2.16250630911151 0.00926266988958541 no 83 0.0152895856572754 51 17112523 SGTC_2984 9022109 38.96 µM 2.1615355649346 0.00928860365271491 no 84 0.0153269963780489 39 6459207 SGTC_2982 9019404 25.97 µM 2.13683113846936 0.00997031823939683 no 85 0.0163058642460732 37 22333232 SGTC_1734 st037168 69.4 µM 2.13682439473818 0.00997051014089842 no 86 0.0163061385985395 41 708907 SGTC_3248 9135562 49.47 µM 2.12623801288088 0.010275763107201 no 87 0.0167417232262214 40 17650701 SGTC_1409 3909-8004 61.9 µM 2.11435297433049 0.0106281434491676 no 88 0.0172425654725064 41 2119279 SGTC_947 3447-0010 211 µM 2.10542844251981 0.010899622644047 no 89 0.0176270150597255 54 748350 SGTC_1680 diphenhydramine 100 µM 2.09911980658697 0.0110951501102291 no 90 0.0179031704309935 61 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3214 9129694 49.47 µM 2.09405204976567 0.011254420741423 no 91 0.0181276719291516 49 17158655 SGTC_2556 citropten 84.59 µM 2.09037070225955 0.0113713617060348 no 92 0.0182922562927285 37 2775 A potential DNA crosslinker. SGTC_2201 6605497 169.863 µM 2.07928519480753 0.0117299006875845 no 93 0.018795572549533 35 670741 SGTC_3134 9127454 49.47 µM 2.06946965667108 0.0120555143359491 no 94 0.0192510179340609 20 24262820 SGTC_1229 0139-0193 12.2 µM 2.06806437115437 0.0121027677727296 no 95 0.0193169852254129 65 3090752 SGTC_155 k072-0202 43.6 µM 2.06277852182746 0.0122819478304843 no 96 0.0195668377853685 54 5857737 SGTC_3020 9089140 49.47 µM 2.06100583854317 0.0123425508380213 no 97 0.0196512415384678 53 17217859 SGTC_77 0828-0286 12.516 µM 2.04864807239964 0.012772269565325 no 98 0.0202482701536789 52 745345 SGTC_2331 7980721 200 µM 2.04169979226755 0.0130195219880372 no 99 0.0205906596980036 66 2981221 SGTC_1179 1021-1431 9.29 µM 2.03759025747563 0.013167697320673 no 100 0.0207954635882954 49 2840958 SGTC_732 3970-1727 52.7 µM 2.03100327361838 0.0134082405552785 no 101 0.0211273312609892 49 1275699 SGTC_2406 ethylparaben 405.7 µM 2.02195224126283 0.0137449489083954 no 102 0.0215906429966566 48 8434 A possible steroid mimic. SGTC_2704 st078022 71.1 µM 2.01781889005504 0.0139011244122037 no 103 0.0218050634017057 52 54697681 SGTC_426 0988-0037 14.6 µM 2.01454226647923 0.0140260140743174 no 104 0.0219763159828447 65 5383008 SGTC_1634 st006576 41 µM 2.00601878760321 0.0143554286300509 no 105 0.022427121774377 46 3915356 SGTC_898 1000-0849 28.3 µM 2.00525848093355 0.014385133930256 no 106 0.0224677104961253 61 6751807 SGTC_2864 9034755 47.6 µM 2.00269109354815 0.0144858335942827 no 107 0.0226052276824041 43 4930451 SGTC_183 3914-0051 30.55 µM 1.99936134164392 0.0146173385599126 no 108 0.0227846357592067 32 1596232 SGTC_1840 st055363 71 µM 1.99481741999525 0.0147984524148164 no 109 0.0230313983633516 39 676033 SGTC_2268 7933382 153.85 µM 1.99462449973509 0.0148061844471831 no 110 0.023041924723077 60 935025 YOR257W CDC31 SGTC_2939 9044578 71.43 µM 1.99386162298876 0.0148367937534229 no 111 0.023083589467974 46 2653634 SGTC_2887 9044784 58.44 µM 1.99260866936759 0.0148871847555209 no 112 0.0231521575690205 82 6465546 SGTC_2012 4023501 200 µM 1.99219797453948 0.0149037339768012 no 113 0.0231746701974886 75 3477460 SGTC_2080 5212524 12.4 µM 1.98573643042197 0.0151661956483282 no 114 0.0235312988097787 55 260183 SGTC_3057 9095946 49.47 µM 1.97484016142827 0.015617788030777 no 115 0.0241431449019952 48 24540043 SGTC_377 3970-0964 33.1 µM 1.96455413000987 0.0160546280480889 no 116 0.0247329327069382 56 16481235 SGTC_410 α-linolenic acid 100 µM 1.96436192103067 0.0160628896938352 no 117 0.0247440677483259 52 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2315 7733312 200 µM 1.96198292277918 0.0161654472817097 no 118 0.0248822362457389 63 726316 SGTC_485 niflumic acid 177 µM 1.96077654054826 0.0162176679348595 no 119 0.0249525479082715 47 4488 A COX2 inhibitor. SGTC_945 3381-0768 11.3 µM 1.95474882329997 0.016480759832345 no 120 0.0253063621548635 62 1126236 YIL048W NEO1 SGTC_1427 4048-4900 550 nM 1.95171376297909 0.0166146085056503 no 121 0.0254860988335108 52 24132586 SGTC_1105 epirubicin 18.1 µM 1.95087632655186 0.0166517034895752 no 122 0.0255358797011372 68 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1320 1313-0481 95.3 µM 1.94575288255273 0.0168801974369756 no 123 0.0258422154667479 37 6813365 YLR208W SEC13 SGTC_3116 9124943 49.47 µM 1.9427697887555 0.0170144676661157 no 124 0.0260219898529852 54 41905195 YPL160W CDC60 SGTC_1807 st050092 58.9 µM 1.92937519112398 0.0176286733152765 no 125 0.0268421506475966 48 5008496 SGTC_2167 5876490 200 µM 1.92432032368422 0.0178653314369263 no 126 0.0271572223130529 44 686534 SGTC_176 1486-1328 72.834 µM 1.91949206726957 0.0180939051174759 no 127 0.0274610446345912 76 22310231 SGTC_1093 fluphenazine 7.97 µM 1.91328261654309 0.0183915262743323 no 128 0.0278559409585361 50 6602611 An atypical antipsychotic. SGTC_535 2293-4129 48.2 µM 1.91065086476088 0.0185189196065195 no 129 0.0280247315435837 73 396118 YIL048W NEO1 SGTC_1374 2889-5571 141 µM 1.90900663309846 0.0185988915138192 no 130 0.0281306179963307 108 2853281 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.89977291139247 0.0190534818711067 no 131 0.0287314636349148 49 6312947 SGTC_1126 isoteolin 1.0172 µM 1.89665989925024 0.0192088547399362 no 132 0.0289364197386621 55 133323 SGTC_886 0866-0150 153 µM 1.89521420852056 0.0192813757090917 no 133 0.0290320142625155 53 271463 SGTC_1071 trifluoperazine 6.31 µM 1.89059876619437 0.0195144618136071 no 134 0.0293389625418799 55 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2814 7977482 42.97 µM 1.89014934678748 0.019537285436864 no 135 0.0293689944672414 83 6456762 SGTC_375 3970-0961 9.27 µM 1.87863021896243 0.0201300653624697 no 136 0.0301475009861779 61 2898222 SGTC_1855 st056195 39.6 µM 1.87579043035173 0.0202785238808314 no 137 0.0303420312811045 55 4028379 SGTC_286 k060-0067 22.9 µM 1.87427350872914 0.0203582051555645 no 138 0.0304463684408994 70 5985051 SGTC_2595 hexamethylquercetagetin 100 µM 1.87272389591767 0.0204398774996707 no 139 0.0305532609138821 70 386331 SGTC_1655 st012546 55.1 µM 1.86920250328939 0.0206265053836756 no 140 0.0307973230709634 48 720985 YLR208W SEC13 SGTC_2362 9071156 126 µM 1.86791775216661 0.0206949534483417 no 141 0.0308867680308245 55 653133 SGTC_1976 st070609 63.5 µM 1.86668495624774 0.0207608142361809 no 142 0.0309727978890011 56 682556 SGTC_999 SEC7.066 22.7 µM 1.85626395238364 0.0213246687532342 no 143 0.0317079722520371 78 740511 YDR170C SEC7 SGTC_787 4152-0075 138 µM 1.85201549232252 0.0215582301316571 no 144 0.0320117991433912 61 9566539 SGTC_373 0844-0104 25.9 µM 1.84599727119338 0.0218927827649198 no 145 0.0324463008264886 80 5375804 SGTC_1136 pergolide 1.05886 µM 1.8435450719031 0.0220303521009387 no 146 0.0326247336696441 88 47811 A dopamine receptor agonist. SGTC_2518 prenyletin 46.28 µM 1.84257357180237 0.0220850550993945 no 147 0.0326956477566103 30 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1020 4335-0961 93.3 µM 1.83334087527347 0.0226106732403501 no 148 0.0333759471383447 70 669075 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.82989479514564 0.0228095431232523 no 149 0.0336328359505876 72 5393153 SGTC_3131 9127911 49.47 µM 1.8278536601046 0.0229280285542918 no 150 0.0337857586755768 56 45595681 SGTC_2109 5483026 200 µM 1.81991778217464 0.0233936347896717 no 151 0.0343857632486726 122 759335 SGTC_2177 5811945 192 µM 1.81113945503718 0.0239179108987164 no 152 0.0350596337070176 61 5343475 SGTC_2218 6965428 192.983 µM 1.80904535803566 0.0240444271167752 no 153 0.0352219784856016 48 675684 SGTC_1147 3809-1045 12.3 µM 1.80867301392272 0.0240669813004363 no 154 0.0352509089208586 72 325925 SGTC_562 3772-2733 112 µM 1.80610516204391 0.0242230095289173 no 155 0.0354509573364925 63 2876874 YIL048W NEO1 SGTC_685 1278-0033 54.9 µM 1.8047593192578 0.0243051245926328 no 156 0.03555617640591 77 3590572 SGTC_2026 5148700 152 µM 1.80325721555664 0.0243970496417557 no 157 0.0356739142669119 63 79838 SGTC_3192 9110362 49.47 µM 1.8008173361533 0.0245469862813727 no 158 0.0358658377457075 60 16649480 SGTC_3154 9100113 49.47 µM 1.79966973614947 0.0246177761144861 no 159 0.0359564012475519 77 25237525 SGTC_152 4469-0003 551.229 µM 1.79494533471333 0.0249110080531462 no 160 0.0363312049782839 111 697280 SGTC_1724 st037281 8.293 µM 1.78958530003609 0.025247233022559 no 161 0.0367603017011486 74 574124 YDL195W SEC31 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.78241800093504 0.0257027586495381 no 162 0.0373405460896763 66 688669 SGTC_1873 rapamycin 2 nM 1.78193551917161 0.0257336688911683 no 163 0.037379873730871 61 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_934 2950-0684 338 µM 1.78100282743853 0.0257935100889126 no 164 0.0374559944188239 69 1121253 SGTC_1024 4507-0395 26 µM 1.77253852843206 0.0263419192382723 no 165 0.038152602782913 63 4201836 SGTC_297 0986-0032 24 µM 1.76887647426835 0.0265821895048087 no 166 0.0384572454931875 73 2847425 SGTC_3210 9128157 49.47 µM 1.76742256939841 0.0266780877613286 no 167 0.0385787429726986 76 17590849 SGTC_2983 9022671 12.99 µM 1.76620387860243 0.0267586939710289 no 168 0.0386808252937916 61 6405161 SGTC_7 0192-1582 4.227 µM 1.75873053665014 0.0272574525717205 no 169 0.0393116440575607 91 252616 SGTC_1654 st012436 41.8 µM 1.75642823330659 0.0274126581845475 no 170 0.0395076577733798 38 4323132 SGTC_2524 avocatin b 10.57 µM 1.75594847892475 0.0274450925685647 no 171 0.0395486030715183 39 6710748 SGTC_1685 st024049 53.0905 µM 1.75068276649909 0.0278031951934438 no 172 0.0400002847838687 66 1941139 SGTC_723 4182-0001 115 µM 1.74901159571524 0.0279176562588207 no 173 0.0401445075160835 61 744821 YLR208W SEC13 SGTC_1958 st076513 41.9 µM 1.74741591631121 0.0280273128511356 no 174 0.0402826092892076 63 732122 YGL099W LSG1 SGTC_2373 9071805 200 µM 1.74572830497769 0.028143677133816 no 175 0.0404290871120776 57 10149009 SGTC_1887 st057648 70.8 µM 1.74148802394832 0.0284378292436019 no 176 0.0407990353528948 89 688672 SGTC_544 k015-0020 52.4 µM 1.74081557904905 0.028484711524615 no 177 0.0408579551342724 85 3008304 SGTC_22 0964-0034 14.468 µM 1.73834736016838 0.0286573451195772 no 178 0.0410748130135915 110 138402 SGTC_3008 9078912 71.4286 µM 1.73761200870109 0.0287089454137417 no 179 0.0411396012073885 61 16648731 SGTC_761 k216-0224 480 µM 1.73609662869233 0.0288155247097535 no 180 0.041273375194813 78 1340404 SGTC_1912 st060209 90.8 µM 1.73454917224052 0.0289246992457241 no 181 0.0414103444856469 81 688787 SGTC_90 0870-0863 4.608 µM 1.73283207662237 0.0290462441566291 no 182 0.0415627598830535 82 1738164 SGTC_1690 st023502 41.2 µM 1.72719444739989 0.0294482924419406 no 183 0.042066373866194 72 24207482 SGTC_1145 3546-0597 10.2 µM 1.72711125461087 0.0294542597654861 no 184 0.0420738423623093 69 875334 SGTC_234 nsc-17383 10.7 µM 1.72156074072229 0.0298546655698727 no 185 0.0425745600669439 81 408974 SGTC_632 0781-2353 4.65 µM 1.71130717921995 0.0306062163279729 no 186 0.0435122108784259 114 6811515 YHR007C ERG11 SGTC_1040 k898-0338 155 µM 1.70422921264817 0.0311340949426601 no 187 0.0441691368263985 64 20969351 SGTC_2943 9068529 45.32 µM 1.69581094694246 0.03177171727388 no 188 0.0449608443416897 102 3270634 SGTC_103 0844-0104 51.839 µM 1.69412419279754 0.0319007653330673 no 189 0.0451208430103318 144 5375804 SGTC_1077 5-fluorocytosine 377 nM 1.69185435122264 0.0320751064922882 no 190 0.0453368737794367 93 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_730 1436-0052 41.2 µM 1.68953712381742 0.0322538979670591 no 191 0.0455582718953091 75 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1225 1216-0074 20.6 µM 1.68915718232246 0.0322832916463101 no 192 0.0455946559949587 62 4241466 SGTC_3296 9122258 64.045 µM 1.689010716035 0.032294628722188 no 193 0.0456086881917072 62 4730474 SGTC_440 fluspirilene 35.1 µM 1.68749066691173 0.0324124807016576 no 194 0.0457545215192686 76 3396 An atypical antipsychotic. SGTC_2363 9053361 176 µM 1.68605978067403 0.0325237437418259 no 195 0.0458921428005953 82 6469797 YMR079W SEC14 SGTC_1511 0906-3109 28.5 µM 1.6781839039209 0.0331418101727585 no 196 0.046655601508359 79 2882180 SGTC_459 nigericin 15.3 µM 1.67726007478978 0.0332149384207572 no 197 0.0467458180795297 89 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2709 st078560 56 µM 1.67633896200148 0.0332879839245464 no 198 0.0468359086686625 91 17250903 SGTC_743 1275-0778 158 µM 1.67103471070952 0.0337111970052846 no 199 0.0473574109629485 96 2849257 YMR203W TOM40 SGTC_2593 nobiletin 86.24 µM 1.66981256103111 0.0338093343227567 no 200 0.0474782271934862 79 72344 An anti-infammatory. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.66654819441694 0.0340726122700884 no 201 0.0478021387168172 102 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_857 0438-0306 1.35 µM 1.65196724191864 0.035269255823494 no 202 0.0492706144734715 74 4686136 SGTC_2394 5221648 200 µM 1.64544080111441 0.0358159325276194 no 203 0.0499394706549696 97 788586 SGTC_2339 9000433 200 µM 1.6451081560788 0.0358439809247543 no 204 0.0499737544701439 75 2988954 SGTC_3088 9117578 49.47 µM 1.64477823391962 0.0358718175047595 no 205 0.0500077761907678 82 678341 SGTC_1368 1852-0141 284 µM 1.64031670707602 0.0362499928180488 no 206 0.0504696668093235 79 2838987 SGTC_2903 5923464 63.88 µM 1.63872965796361 0.036385301413084 no 207 0.0506347872543873 71 2876576 SGTC_736 0958-0254 92.6 µM 1.63865341835745 0.0363918118391779 no 208 0.0506427302269402 81 6812352 SGTC_1905 st060207 84.5 µM 1.63615252500854 0.0366059029515765 no 209 0.0509038347883817 93 1948547 SGTC_2776 terbinafine 19.92 µM 1.63547978382439 0.0366636690684451 no 210 0.0509742546210968 89 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2203 7227154 166.4 µM 1.63432551637654 0.0367629560044707 no 211 0.0510952593225054 53 896304 SGTC_2241 6772625 37.8075 µM 1.63183100276774 0.0369782784287889 no 212 0.0513575461433071 79 2285411 SGTC_1510 1123-0200 71.5 µM 1.62912916863951 0.0372126583349845 no 213 0.0516428387787247 102 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2720 fluspirilene 36.88 µM 1.62893288481872 0.0372297328398192 no 214 0.0516636138153457 70 3396 An atypical antipsychotic. SGTC_1005 4092-0690 4.4 µM 1.62829973164841 0.0372848537407052 no 215 0.0517306731837589 101 1529343 SGTC_1194 1488-0194 225 µM 1.6257709624637 0.0375056680184073 no 216 0.0519991938473886 67 1391452 SGTC_3274 9138298 49.47 µM 1.61920096431919 0.0380843607948258 no 217 0.0527020153005957 95 17015756 SGTC_2606 farnesol 9.78 µM 1.61914636395858 0.0380892003987569 no 218 0.0527078875647568 105 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_579 4491-1009 110 µM 1.61608322930374 0.03836151150696 no 219 0.0530381598269691 104 1271041 SGTC_81 0411-0046 9.971 µM 1.61220327491768 0.0387087136716285 no 220 0.0534588564363239 134 12925265 SGTC_1648 st011736 69.8 µM 1.61109702047708 0.038808175806466 no 221 0.0535792888435159 74 2855514 SGTC_2896 9052656 71.43 µM 1.59478802631739 0.0402988013426097 no 222 0.0553798227537343 121 6469436 SGTC_442 cape 100 µM 1.59391565080967 0.0403798279934868 no 223 0.055477464251244 61 5281787 SGTC_1883 5-benzylidenerhodanine 20 µM 1.59039479151731 0.0407081924699559 no 224 0.0558729218180438 91 1273210 SGTC_404 fumagillin 50 µM 1.58646854707064 0.041076916276645 no 225 0.0563165307975132 90 12015870 A methionine aminopeptidase binder. SGTC_2335 9018011 154.17 µM 1.58413384575525 0.0412974551832184 no 226 0.0565816318582052 90 6458208 SGTC_2211 7117706 200 µM 1.58089949858285 0.0416045605861765 no 227 0.0569505095014061 71 822771 SGTC_593 1203-0218 61.7 µM 1.57346051076566 0.0423179253978248 no 228 0.0578061125886939 100 3666956 SGTC_2352 9027995 87.8 µM 1.57273658644673 0.0423878715938834 no 229 0.0578899122388094 83 2997347 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.56811933104247 0.0428361980149615 no 230 0.0584266429617207 93 23847180 SGTC_1953 st076800 12.1 µM 1.56556959601095 0.0430854100607601 no 231 0.0587247062372723 109 297591 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.55863264086102 0.0437693624558966 no 232 0.0595416764380998 88 3256 An antibiotic and ribosome inhibitor. SGTC_769 0302-0231 76 µM 1.54731964566534 0.0449035386970739 no 233 0.0608930933771744 118 571869 YER009W NTF2 SGTC_2688 kanamycin b 96.69 µM 1.54251516706899 0.0453923116159827 no 234 0.0614742275747761 128 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3099 9120367 49.47 µM 1.53805779610476 0.0458495901777118 no 235 0.0620172419436584 85 24824940 SGTC_2884 9058502 51.95 µM 1.53754709550463 0.0459022181320594 no 236 0.062079695726536 85 6471554 SGTC_88 0180-0332 8.668 µM 1.5337388247114 0.0462961945089046 no 237 0.0625469591348352 109 3101745 SGTC_2404 5161160 200 µM 1.52867723362797 0.0468240278116747 no 238 0.0631722394441258 127 2831543 SGTC_1521 st012942 49.4 µM 1.51967829960809 0.0477743669541036 no 239 0.064295924066688 92 24207259 SGTC_2867 9039098 71.43 µM 1.5174797529121 0.0480088781572043 no 240 0.0645728008076481 107 6463460 SGTC_2091 4-phenylthiadiazole 200 µM 1.50983739417941 0.0488312370626308 no 241 0.0655424603663039 89 270010 SGTC_1657 st012939 43.4 µM 1.50555918257254 0.0492964873900324 no 242 0.0660901866751323 67 24207257 SGTC_937 3122-0005 46.7 µM 1.49974857307846 0.0499340445890871 no 243 0.06683977162029 94 759535 SGTC_2725 haloperidol 53.21 µM 1.49945685758878 0.0499662250252772 no 244 0.0668775764285114 116 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1063 disulfiram 1.84 µM 1.49931775557569 0.0499815758108475 no 245 0.0668956091486167 92 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1405 3909-7894 12 µM 1.49913097067379 0.0500021946196628 no 246 0.0669198292353867 82 7104060 SGTC_916 4466-0038 42 nM 1.49704513841641 0.0502329065058636 no 247 0.0671907566660717 132 5722064 YGL116W CDC20 SGTC_2699 st077704 54.6 µM 1.48648120376513 0.0514144324272219 no 248 0.0685759424817834 91 645852 SGTC_1157 4092-0394 27.6 µM 1.48618176434182 0.0514482427132299 no 249 0.0686155248182044 85 3659885 SGTC_3334 9142812 21.919 µM 1.48388791759565 0.0517078323032846 no 250 0.0689193288862725 96 45283678 SGTC_2732 terfenadine 20 µM 1.47503327751298 0.0527196724346012 no 251 0.0701017985010628 97 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1983 st071813 46.9 µM 1.47456421695165 0.0527737081613904 no 252 0.0701648705491825 99 11838595 SGTC_1762 st045503 25.4615 µM 1.47314582927122 0.0529373736378527 no 253 0.0703558590688269 84 4645554 SGTC_1673 st016611 27.3 µM 1.47180633698397 0.0530923048636992 no 254 0.0705365909434812 112 5226799 SGTC_840 0245-0196 390 µM 1.46861862387861 0.0534624549528895 no 255 0.0709681302648747 103 3827528 SGTC_575 k072-0246 11.9 µM 1.46707908874073 0.0536419530992172 no 256 0.0711772709666415 103 6796779 SGTC_864 0469-0573 172 µM 1.46611596591206 0.0537544884523658 no 257 0.0713083484087033 100 689425 SGTC_811 0416-0114 265 µM 1.46552388967072 0.0538237618972225 no 258 0.0713890197080576 97 6612453 SGTC_1424 4048-1941 275 µM 1.45795667278858 0.0547153720646432 no 259 0.0724262429708105 97 X1424 SGTC_2303 7774051 200 µM 1.45788367891909 0.0547240291113655 no 260 0.0724363040185206 109 2953184 SGTC_2636 apigenin dimethyl ether 100 µM 1.45545222099311 0.0550130184327383 no 261 0.07277205417817 104 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.45471383668196 0.0551010169087585 no 262 0.0728742501863032 124 165506 SGTC_439 amiodarone 34.4 µM 1.4496975138018 0.0557017949622577 no 263 0.0735714446815768 108 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_71 0417-1750 47.813 µM 1.43974284046681 0.0569093115564841 no 264 0.0749700840489019 96 6811472 SGTC_2079 5212404 121 µM 1.43735329105916 0.0572022134678026 no 265 0.0753088168323924 84 758462 SGTC_1809 st050081 57.6 µM 1.43481695637468 0.0575144044479994 no 266 0.0756696323479571 106 5036894 SGTC_998 3996-0085 177 µM 1.42833547396177 0.0583182831709834 no 267 0.0765976609972272 105 715391 SGTC_360 0957-0399 1.01 µM 1.42178340012848 0.0591398606473464 no 268 0.0775445700064077 112 6752301 YPR165W RHO1 SGTC_2900 5328528 85.29 µM 1.42106294760703 0.0592307508457767 no 269 0.0776492302246143 103 795359 SGTC_1704 st028805 70.8 µM 1.41647378175354 0.0598122802623369 no 270 0.0783184175805265 111 2876101 SGTC_3197 9113331 49.47 µM 1.41607773345271 0.0598626755890582 no 271 0.0783763732928473 112 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_696 1560-0013 611 µM 1.41476645796529 0.0600297667554426 no 272 0.0785684908153603 117 1650269 SGTC_845 0330-0138 4.51 µM 1.41217306000219 0.0603613094622535 no 273 0.0789495053855489 122 9039800 SGTC_895 0964-0006 13.7 µM 1.41094986231648 0.0605181808640809 no 274 0.0791296990906957 142 6738897 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.41040718910366 0.0605878791280854 no 275 0.079209741919241 111 165521 SGTC_3032 9089427 49.47 µM 1.4070993149728 0.0610140849657777 no 276 0.0796989706140151 91 17173707 SGTC_810 3825-7150 143 µM 1.4022245556232 0.0616464448359721 no 277 0.0804241005581339 74 22330411 YGL099W LSG1 SGTC_680 0417-1641 114 µM 1.39673365144934 0.0623648475808775 no 278 0.0812468403710347 114 2835990 SGTC_23 0213-0011 39.996 µM 1.39419789582498 0.0626988093001066 no 279 0.08162892659724 117 627608 SGTC_1316 1272-0050 65.9 µM 1.38422115249342 0.0640263020150528 no 280 0.0831453741906212 106 7340392 SGTC_2421 5690543 90.72 µM 1.38236073510017 0.0642762469726311 no 281 0.0834304829808236 123 3397993 SGTC_2253 7938677 135.83 µM 1.37960832006877 0.0646474208376329 no 282 0.08385363716699 96 2301972 SGTC_960 1222-0186 7.7 µM 1.37955261895714 0.0646549494983695 no 283 0.0838622172229464 115 3126296 SGTC_2683 piperine 63.03 µM 1.37890217046092 0.0647429156796856 no 284 0.0839624594471044 115 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1514 1189-1591 158 µM 1.37864139458089 0.0647782089084674 no 285 0.0840026735196004 116 767698 YMR146C TIF34 SGTC_500 h-89 112 µM 1.37506463689671 0.0652637938552208 no 286 0.0845557032847842 123 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_428 3448-4153 16.5 µM 1.37493978349234 0.0652807949749272 no 287 0.084575057035041 108 3834874 SGTC_1392 3455-1037 33.9 µM 1.36934544657405 0.0660460999844983 no 288 0.0854456591343196 103 981132 SGTC_1351 1496-0003 46.5 µM 1.36325463399327 0.0668872069856838 no 289 0.0864011370848766 109 3891978 SGTC_2770 toltrazuril 17.5 µM 1.36309174023048 0.066909814946401 no 290 0.0864267997989711 96 68591 Kills coccidiodes. SGTC_2059 5238311 157 µM 1.36287790647743 0.0669395018208981 no 291 0.0864604963844894 120 703021 SGTC_1617 st002906 78 µM 1.35905489814274 0.0674719771616534 no 292 0.0870645966130599 116 5150859 SGTC_2974 9094440 9.66 µM 1.35701823104762 0.067756981068284 no 293 0.0873877089099495 126 25236134 SGTC_824 1304-0008 100 µM 1.35496550018049 0.0680451729180502 no 294 0.0877142745467916 121 768245 SGTC_568 1193-0097 7.48 µM 1.35293084022755 0.0683317606894964 no 295 0.0880388628991357 139 3646150 SGTC_1270 0831-1170 17.3 µM 1.35092964412279 0.0686145426542488 no 296 0.0883589855634165 127 6764716 SGTC_1007 4101-0031 70 µM 1.35047968284557 0.0686782492087191 no 297 0.0884310832139986 127 1146276 SGTC_2123 5259487 200 µM 1.34858846809718 0.0689465106274133 no 298 0.0887345933795573 109 2173474 SGTC_2487 5918373 44.05 µM 1.3421760780006 0.0698620976366494 no 299 0.0897694554946775 140 2876279 SGTC_1921 5740136 50 µM 1.3393756445461 0.0702648784597607 no 300 0.090224207060988 91 1774243 SGTC_833 3852-0053 558 µM 1.33689617954618 0.0706229834616339 no 301 0.0906282640378328 130 3123681 SGTC_2380 9035439 200 µM 1.33583883494212 0.0707761199292416 no 302 0.0908009782714283 113 6462575 SGTC_874 0599-0792 117 µM 1.33517679149137 0.0708721342722834 no 303 0.0909092454568312 143 765305 SGTC_1012 4112-3522 18 µM 1.33069352615738 0.0715249650784326 no 304 0.0916449370335821 114 3112398 SGTC_2464 5717415 7.67 µM 1.33043691232259 0.0715624710658587 no 305 0.0916871797494772 108 5285744 SGTC_1498 4478-3555 97.6 µM 1.33030076153989 0.0715823766241537 no 306 0.0917095981890224 84 3437919 SGTC_782 0083-0095 30.5 µM 1.32370319784824 0.0725520551820732 no 307 0.0928008179998927 111 3591729 An indicator and reagent. SGTC_18 0111-0177 500 nM 1.32049995866805 0.0730264656258742 no 308 0.0933340749099097 129 721752 SGTC_3130 9127414 49.47 µM 1.3181413753567 0.0733772946791146 no 309 0.0937281630354733 119 1494646 SGTC_483 fpl-64176 144 µM 1.3181336237661 0.073378449816244 no 310 0.0937294602461079 101 3423 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.31606062444337 0.0736878663692423 no 311 0.094076847779227 169 16725076 SGTC_1178 0988-0033 191 µM 1.31197818315342 0.0743001277873452 no 312 0.0947637479147077 123 5392207 SGTC_1404 3909-7820 48.3 µM 1.3099224513791 0.0746099017320038 no 313 0.0951110355595598 133 23741373 SGTC_1738 st035555 74 µM 1.30651723558593 0.0751251939678622 no 314 0.0956883608233222 141 5331140 SGTC_1908 st060353 56.5 µM 1.30354884409597 0.0755765940552876 no 315 0.096193726159963 143 4227716 SGTC_2068 5226020 147 µM 1.30180644922644 0.0758425190296027 no 316 0.0964912793018105 124 1810509 SGTC_3212 9128307 49.47 µM 1.30166516816998 0.0758641125925902 no 317 0.0965154358290865 111 27243542 SGTC_252 miconazole 1.30953 nM 1.29950886373093 0.0761942660300548 no 318 0.0968846767876991 150 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2875 9039966 71.43 µM 1.29122999205879 0.0774720155099801 no 319 0.0983119690311906 112 6463691 SGTC_2961 9083290 32.55 µM 1.29044427748592 0.0775941220530308 no 320 0.098448223579806 121 17741490 SGTC_120 rhodamine 6G 52.259 µM 1.29013059460566 0.0776429117609065 no 321 0.0985026594424156 180 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2237 6667747 47.222 µM 1.28976587488993 0.0776996689315819 no 322 0.0985659798329616 113 729940 YDL015C TSC13 SGTC_1795 st049545 62.3 µM 1.28795283335119 0.0779822794407957 no 323 0.0988811912131828 90 5291882 SGTC_1088 bifonazole 369 nM 1.28786029071424 0.0779967255535589 no 324 0.0988973002319825 113 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2854 9024559 71.43 µM 1.28561512842547 0.0783478229093903 no 325 0.0992887071478792 113 3163529 SGTC_3085 9117376 49.47 µM 1.28553325699131 0.0783606485333952 no 326 0.0993030014514367 138 16480349 SGTC_314 1671-0008 2.74 µM 1.28544331679818 0.0783747400092222 no 327 0.0993187062503337 146 3913060 SGTC_3022 9087993 49.47 µM 1.28439215073196 0.0785395750591108 no 328 0.0995023889979452 126 17173644 SGTC_2780 5215298 71.43 µM 1.28362029684015 0.0786607779416891 no 329 0.0996374222101262 148 2834131 SGTC_628 1636-0253 16 µM 1.27247373262124 0.0804269435545417 no 330 0.10160242559622 135 4456143 SGTC_1326 1431-2094 10.8 µM 1.26570579443739 0.0815138422341542 no 331 0.102809216519361 141 616278 SGTC_2004 4023728 41.89 µM 1.26143421000246 0.0822055178189399 no 332 0.103576224682736 168 360084 YDR527W RBA50 SGTC_559 1550-0661 158 µM 1.25931065949442 0.0825510141847208 no 333 0.103959072273633 118 5830875 SGTC_799 1310-0557 151 µM 1.2584984565501 0.0826834461645864 no 334 0.104105772522287 138 5354492 SGTC_2945 9067681 61.76 µM 1.25607287318137 0.0830798961008235 no 335 0.104544775118285 157 16456930 SGTC_3059 1327-0034 3 µM 1.25568759688244 0.0831429990100971 no 336 0.104614628927921 136 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1118 chelidonine 707.474 nM 1.25089437716819 0.0839310778669994 no 337 0.105486507797162 117 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2927 9011802 47.9 µM 1.25015521656735 0.0840531047813114 no 338 0.105621426252986 116 43912568 SGTC_222 nsc-310342 10.666 µM 1.24542377377185 0.0848373685591543 no 339 0.106488009467653 115 432556 SGTC_2958 9077254 16.72 µM 1.24341029809687 0.0851727729774244 no 340 0.106858338682194 116 16457351 SGTC_2805 7950783 58.44 µM 1.2433142764814 0.0851887930282039 no 341 0.106876022675643 138 1178958 YDL195W SEC31 SGTC_130 0136-0219 337.655 µM 1.24066854891879 0.0856310894660074 no 342 0.107364108699063 147 234244 SGTC_3187 9109394 49.47 µM 1.23645257295304 0.0863394398869195 no 343 0.108145192247406 145 17098090 SGTC_206 4546-0025 72.014 µM 1.23605739622908 0.0864060597579161 no 344 0.108218614814652 136 6620745 YIL048W NEO1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.23589047590917 0.0864342111425414 no 345 0.108249638850513 158 6708760 SGTC_214 4373-3496 70 µM 1.23408408204625 0.0867393012128791 no 346 0.108585787188473 170 3779166 SGTC_3280 9140961 49.47 µM 1.23402040027694 0.0867500713828088 no 347 0.108597651291934 137 4901226 SGTC_512 prima-1 270 µM 1.22742676354049 0.0878706354269513 no 348 0.109831116171893 117 322968 A re-activator of the apoptotic function of mutant p53. SGTC_851 0394-0702 453 µM 1.22410828189023 0.0884386666006227 no 349 0.110455691104507 170 762646 SGTC_607 4491-0986 66.8 µM 1.21891120316629 0.0893337518165454 no 350 0.111438948524711 116 698981 YDR232W HEM1 SGTC_1620 st003704 16.5 µM 1.21887239775344 0.0893404604708332 no 351 0.111446313771809 145 2834414 SGTC_2207 7258803 200 µM 1.21787537165916 0.0895129542294576 no 352 0.111635668280942 133 3666799 SGTC_2763 lisinopril 49.32 µM 1.21684330497457 0.0896917710667307 no 353 0.111831920010508 130 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2831 7999036 19.48 µM 1.21680900669087 0.0896977181756851 no 354 0.111838446203921 145 2988270 SGTC_2584 androsterone 48.74 µM 1.21657395326728 0.0897384828659403 no 355 0.11188317892334 150 2754130 A steroid. SGTC_1335 1486-0900 202 µM 1.21617439189991 0.0898078093331632 no 356 0.111959248299642 120 X1335 SGTC_920 mycophenolic acid 780.421 nM 1.21526496580414 0.0899657490199635 no 357 0.112132524707204 123 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2722 naftopidil 47.16 µM 1.21434282610604 0.0901261073345824 no 358 0.112308419132592 133 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1318 1280-3875 124 µM 1.21424452491704 0.0901432142384226 no 359 0.112327181310396 166 373245 SGTC_2444 5485484 36.41 µM 1.21361795318242 0.0902523103285968 no 360 0.112446824060064 157 6790631 SGTC_1717 st033143 58.0435 µM 1.21358429988825 0.0902581726754499 no 361 0.112453252671513 122 674616 SGTC_2147 5545932 89.7195 µM 1.21356565831173 0.0902614201282321 no 362 0.112456813786644 163 797404 SGTC_2102 5377816 72.7585 µM 1.21335022774775 0.0902989554709555 no 363 0.112497973503287 154 1379702 SGTC_1084 voriconazole 435 nM 1.2078837591209 0.0912552835691996 no 364 0.113545988727606 152 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_50 0929-0078 56.389 µM 1.20479537651473 0.0917988879511725 no 365 0.114141152654933 123 1377751 SGTC_20 0481-0013 4.944 µM 1.20455385971785 0.0918414996545167 no 366 0.114187788992953 166 182045 SGTC_1380 2291-0730 164 µM 1.19237545003894 0.0940092209705859 no 367 0.116557031019816 142 2999191 SGTC_640 3381-0960 37.1 µM 1.18824169432706 0.0947535336881974 no 368 0.117369100709437 145 1745025 SGTC_2531 methyl deoxycholate 70.07 µM 1.18798517679285 0.0947998642356914 no 369 0.117419624873687 143 16667744 Haematoxylin. SGTC_728 3030-5151 22.5 µM 1.18533189343508 0.0952800628711529 no 370 0.117943124073629 132 3125388 SGTC_2432 5630864 12.22 µM 1.18412430424057 0.0954992078182538 no 371 0.118181930288622 143 5714970 SGTC_1893 st059353 36.1 µM 1.17796662521096 0.0966224315229839 no 372 0.119404955928711 157 3112488 SGTC_989 1501-0895 10.3 µM 1.17698254404903 0.0968028336779884 no 373 0.119601236801714 132 2830112 SGTC_2083 5306046 65.942 µM 1.17344970524851 0.0974525129096701 no 374 0.120307757299398 140 539837 SGTC_1794 st048918 76.9 µM 1.17094745676151 0.0979146004500453 no 375 0.120809948944086 113 672303 SGTC_1312 1218-2183 165 µM 1.17089794430964 0.0979237600353388 no 376 0.120819900766309 145 6744073 SGTC_1450 4112-4260 37.6 µM 1.16949385727592 0.0981837714152251 no 377 0.121102357348246 158 1633175 SGTC_1980 st071811 45.7 µM 1.1689771161914 0.0982795896694858 no 378 0.121206425668042 161 4974850 SGTC_2360 9040895 200 µM 1.16843479319344 0.0983802251670004 no 379 0.121315713649305 128 4914414 SGTC_1490 4089-0339 670 nM 1.16805437293461 0.0984508624018414 no 380 0.121392416613327 158 742542 SGTC_778 3456-2434 196 µM 1.16580557231767 0.0988691831617687 no 381 0.121846531879672 147 5539063 SGTC_3033 9090887 49.47 µM 1.16492287680087 0.0990337366728492 no 382 0.122025106205103 152 19325384 SGTC_1357 1503-1303 39.5 µM 1.16301508004331 0.0993900754214031 no 383 0.122411692051012 151 292895 SGTC_1678 st019265 80.2 µM 1.16200613600622 0.0995789047228132 no 384 0.122616486252535 134 5367020 SGTC_1322 1348-1070 12 µM 1.16131700882213 0.0997080291797903 no 385 0.122756502506494 154 6758089 SGTC_2061 5245884 80.95 µM 1.1610661265211 0.0997550683396341 no 386 0.122807504384119 159 573863 SGTC_1659 st012954 42.1 µM 1.16058149892716 0.0998459794587467 no 387 0.122906066429928 137 24207262 SGTC_3163 9099914 49.47 µM 1.15690392346371 0.100537827231145 no 388 0.123655807792468 163 16268368 SGTC_1972 st070201 17.4 µM 1.15404459015479 0.101078154202366 no 389 0.12424094418504 148 2829099 SGTC_2309 7664088 163.95 µM 1.14985353536647 0.101873956091898 no 390 0.125102100557504 158 704922 SGTC_1656 st012921 11 µM 1.14709560221352 0.102400117236581 no 391 0.125671055629182 147 6732821 SGTC_2250 alverine citrate 130 µM 1.14570092237363 0.102666946702569 no 392 0.125959461040024 164 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2793 7325131 81.82 µM 1.14504922674517 0.102791801889088 no 393 0.126094383071507 154 4176441 SGTC_3067 9117431 49.47 µM 1.14335257153327 0.103117373263576 no 394 0.126446117956645 190 17150885 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.14112614788246 0.103545737257243 no 395 0.126908715752615 137 6708514 SGTC_1028 k015-0029 4.8 µM 1.13993730798644 0.103774998290441 no 396 0.127156210264263 155 4588309 SGTC_21 0849-0113 22.993 µM 1.13248649259205 0.105220235162151 no 397 0.12871497999189 150 1560156 SGTC_2817 7995342 71.43 µM 1.13092172760859 0.105525594708486 no 398 0.129044018674579 140 18879975 SGTC_1173 0443-0020 122 µM 1.13074347866723 0.105560420114398 no 399 0.129081537821948 165 5331295 SGTC_3343 9148379 18.9835 µM 1.12892803398977 0.105915586285474 no 400 0.129464096789408 143 1955036 SGTC_1558 st069300 45.6 µM 1.12843414051207 0.106012358847012 no 401 0.129568308116945 158 24208000 SGTC_1079 idarubicin 2.36 µM 1.12467259770092 0.106751485292143 no 402 0.130363898813326 181 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1519 esterone 74 µM 1.12285057516367 0.107110838543692 no 403 0.130750480771922 155 698 A steroid. SGTC_765 1319-0117 244 µM 1.12033682223105 0.107608051051823 no 404 0.131285128153616 153 3487746 YGL099W LSG1 SGTC_974 1326-0144 138 µM 1.11384126442672 0.108900547903522 no 405 0.132673645423892 152 5411856 SGTC_897 1000-0139 31.4 µM 1.11287569831036 0.109093626679443 no 406 0.132880909249268 156 6151020 SGTC_1692 fluoroquinolonic acid 71 µM 1.10668405680516 0.110337582540859 no 407 0.134215275401286 155 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_532 1548-0774 215 µM 1.10550384169714 0.110575847901359 no 408 0.134470665343745 166 5932993 SGTC_2193 5925765 200 µM 1.10450592776248 0.110777597318472 no 409 0.134686866793997 147 877370 SGTC_368 fentichlor 4.58 µM 1.10356870623299 0.110967316534204 no 410 0.134890136145584 165 7329 A pesticide. SGTC_2475 5812728 15.03 µM 1.10097326091687 0.11149391986697 no 411 0.135454147426457 154 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1783 st039459 87.517 µM 1.0979466258544 0.11211026530862 no 412 0.136113898236972 177 729761 SGTC_484 loperamide 105 µM 1.09301411954764 0.11311993549105 no 413 0.137193800223344 120 3955 An opioid-receptor agonist. SGTC_1440 4100-1550 40 µM 1.09268639467538 0.11318724899145 no 414 0.137265757680947 162 742806 SGTC_2670 beta-carotene 100 µM 1.09131962882549 0.113468285857544 no 415 0.137566131789844 112 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_988 1497-1057 103 µM 1.09019820552873 0.113699246309306 no 416 0.137812921828011 164 3533044 SGTC_2995 9067767 71.4286 µM 1.08518339351058 0.114736161335901 no 417 0.1389202188804 136 11673567 SGTC_1987 st072290 61.9 µM 1.08431942319533 0.114915482180333 no 418 0.13911159813284 166 54697379 SGTC_111 0083-0039 52.457 µM 1.0840282078584 0.114975970102917 no 419 0.139176146060945 137 759313 SGTC_953 1188-0045 9.7 µM 1.08310282494945 0.115168330359944 no 420 0.139381392616465 166 6144426 SGTC_1051 3253-3903 78 µM 1.08229375463204 0.11533669998723 no 421 0.139561010102181 191 5509239 SGTC_196 k015-0023 18.111 µM 1.08224396313831 0.115347067437605 no 422 0.13957206919187 142 5211998 SGTC_2827 7993847 71.43 µM 1.0819245524517 0.115413590021283 no 423 0.139643027038453 148 2985692 SGTC_3222 9128301 49.47 µM 1.08128265133465 0.115547359036655 no 424 0.139785701074832 173 4911358 SGTC_2733 amorolfine 100 µM 1.0800675312978 0.115800885591318 no 425 0.140056054557355 187 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2223 6903751 107.57 µM 1.07939855679987 0.11594063107655 no 426 0.140205047015235 163 5598863 SGTC_1652 st011932 78 µM 1.07455597014545 0.116955794679049 no 427 0.141286786760915 172 1551076 SGTC_2679 rapamycin 1 nM 1.07431680431798 0.117006094343924 no 428 0.141340357973341 187 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2391 6285546 200 µM 1.07321084474649 0.117238891279091 no 429 0.141588263002717 152 846083 SGTC_341 1486-1430 230 µM 1.07250975206316 0.117386636306145 no 430 0.141745568059059 207 2054753 YPL210C SRP72 SGTC_1023 4482-3888 16 µM 1.07056856899926 0.117796400026643 no 431 0.142181731176836 181 3303168 SGTC_574 1315-0397 40 µM 1.07039729125712 0.117832603525515 no 432 0.142220259016073 201 6794277 SGTC_2872 9044037 25.97 µM 1.06983720699013 0.117951045210821 no 433 0.142346295731205 152 6465195 SGTC_115 0527-0192 112.043 µM 1.06870666722051 0.118190378325957 no 434 0.142600933165363 210 4233931 SGTC_766 1391-0721 126 µM 1.06867824293473 0.118196400115421 no 435 0.142607339284174 193 1020919 YIL115C NUP159 SGTC_1207 2099-0101 141 µM 1.06777639469824 0.118387572633699 no 436 0.142810694223721 171 5837381 SGTC_3054 9094397 49.47 µM 1.0677063589784 0.118402427847733 no 437 0.142826494557076 176 2598354 SGTC_954 1189-0853 2.85 µM 1.06518746723868 0.118937583846857 no 438 0.143395551947989 160 2828194 SGTC_1827 berberine 7.24 µM 1.06182449590789 0.119654729781861 no 439 0.144157683536367 145 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_370 0180-0345 38.7 µM 1.06077043983769 0.119880131282286 no 440 0.144397119556109 151 3989527 SGTC_2993 9054257 71.4286 µM 1.05824641911127 0.120421089184985 no 441 0.144971556813414 181 6470217 YGL055W OLE1 SGTC_1364 1653-0028 37.6 µM 1.05624586891852 0.120851074557178 no 442 0.145427949822338 151 5718652 SGTC_2181 6316240 54.2555 µM 1.05517581562489 0.121081507949322 no 443 0.145672461364343 154 12779990 SGTC_1403 3909-7815 62.9 µM 1.053523743684 0.121437884348434 no 444 0.146050509016451 166 6615483 SGTC_1693 xanthone 101.9 µM 1.0533642357418 0.121472331570771 no 445 0.146087044467926 207 7020 An insecticide. SGTC_2227 7312221 64.1025 µM 1.05306418677239 0.121537148546564 no 446 0.146155787616365 195 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1214 0358-0031 63.7 µM 1.05232068358074 0.121697865835467 no 447 0.146326222591485 172 4301366 SGTC_2398 5228213 48.84 µM 1.05190906684868 0.121786906014142 no 448 0.146420635826675 196 80771 YMR134W ERG29 SGTC_1232 0279-0259 161 µM 1.05184378556535 0.121801031746103 no 449 0.146435613263068 175 1560000 SGTC_2771 fluoxetine 41.05 µM 1.05161389190498 0.121850785891902 no 450 0.146488365783277 162 3386 A selective serotonin reuptake inhibitor. SGTC_655 k060-0012 42 µM 1.05054458656198 0.122082395204238 no 451 0.146733901443626 185 5994525 SGTC_2420 aureobasidin a 50 nM 1.04972296315696 0.122260567023425 no 452 0.146922751461248 143 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1106 tegaserod maleate 11.7 µM 1.04785998088708 0.122665237014013 no 453 0.147351561301972 191 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2070 5230947 200 µM 1.04781241074631 0.122675582308244 no 454 0.147362521675805 193 2835538 SGTC_1267 0828-0272 9.49 µM 1.04316308127785 0.123689647509169 no 455 0.148436384480908 176 745334 SGTC_3347 9188721 44.724 µM 1.04243256651684 0.123849512087559 no 456 0.148605587155729 193 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3078 9116413 49.47 µM 1.04082603584199 0.124201591086031 no 457 0.148978147099588 189 17177322 SGTC_1975 st070967 30.8 µM 1.04048927236316 0.124275483117164 no 458 0.149056322742818 216 261391 SGTC_3223 9129970 49.47 µM 1.04042967274481 0.124288563558957 no 459 0.14907016094 195 17248386 SGTC_2661 dactinomycin 12.96 µM 1.03730802955981 0.124975022970065 no 460 0.149796162423383 164 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3077 9117319 49.47 µM 1.0355086561402 0.125371912149228 no 461 0.150215713021235 183 17154678 SGTC_1391 3442-0225 151 µM 1.03468996481598 0.125552782444461 no 462 0.150406862034268 157 5227075 SGTC_507 nimesulide 162 µM 1.03468784756699 0.125553250436 no 463 0.150407356582055 164 4495 A COX2 inhibitor. SGTC_501 nsc-95397 161 µM 1.03428865635529 0.125641508436763 no 464 0.150500619168522 188 262093 SGTC_2968 9090663 33.37 µM 1.03347368180405 0.125821827198843 no 465 0.150691140320059 218 25236811 SGTC_927 2425-1185 123 µM 1.03187843578666 0.126175308694051 no 466 0.151064534557693 194 730375 SGTC_1444 4112-3581 28 µM 1.02911311569842 0.126789699012006 no 467 0.151713261820489 186 2877249 SGTC_2152 5568786 200 µM 1.02827410215905 0.126976519647238 no 468 0.151910454839665 183 5399883 SGTC_2822 7994718 71.43 µM 1.02803496144648 0.127029803464518 no 469 0.15196669115511 199 1018011 SGTC_2539 epi(13)torulosol 80 µM 1.02770053980109 0.127104343268803 no 470 0.152045356917309 168 6708597 SGTC_51 1013-0126 23.419 µM 1.02561785919159 0.12756924045395 no 471 0.152535872976116 145 1627850 SGTC_1423 4048-0112 5.59 µM 1.02541564010867 0.127614442803485 no 472 0.152583555780773 180 X1423 SGTC_1223 0764-0573 147 µM 1.02298715320923 0.128158156203095 no 473 0.153156959990801 154 1609797 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.02177588495933 0.12842994730765 no 474 0.153443492704726 165 2724 A muscle relaxant with antifungal properties. SGTC_2869 9037858 32.47 µM 1.01667375915267 0.129579181743088 no 475 0.154654326449595 174 27187042 SGTC_2596 sinensetin 100 µM 1.01534156317213 0.129880423107481 no 476 0.154971519207514 178 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2715 st079500 56.4 µM 1.01415729578764 0.130148621075383 no 477 0.155253850982845 190 28246688 SGTC_1402 3909-7673 35.9 µM 1.01206092037362 0.130624320936049 no 478 0.15575446309718 179 5328014 SGTC_1616 st002734 56.1 µM 1.00958294661865 0.131188159946043 no 479 0.156347571657938 188 4026101 SGTC_124 0136-0217 7.121 µM 1.00938210475378 0.131233933107232 no 480 0.1563957086929 209 3976905 SGTC_1191 1487-1166 10.6 µM 1.00816330353241 0.131511942353887 no 481 0.15668803577887 170 3955771 SGTC_2023 5144124 124 µM 1.00286111310312 0.13272610463203 no 482 0.15796393870194 171 2830192 SGTC_1096 rimcazole 32.2 µM 1.00020812309628 0.133336508736097 no 483 0.158604899475568 169 18528119 A dopamine reuptake inhibitor. SGTC_1766 st045414 44.774 µM 0.999998310703885 0.133384864975581 no 484 0.158655662692007 180 253960 SGTC_1473 k844-0725 134 µM 0.998840622300307 0.133651898629694 no 485 0.158935952016686 205 54682906 SGTC_2138 5575593 77.673 µM 0.998297062924406 0.133777403343136 no 486 0.159067665706187 175 762213 SGTC_2775 cyproheptadine 69.59 µM 0.998198064072739 0.133800270323368 no 487 0.159091662509316 180 2913 A selective serotonin reuptake inhibitor. SGTC_1010 4112-3296 15.2 µM 0.996833721624997 0.134115682920895 no 488 0.159422613518678 159 704384 SGTC_887 0885-0007 9.62 µM 0.99328114970539 0.134939371949566 no 489 0.160286480600104 190 5719458 SGTC_2255 7941087 197.44 µM 0.992466031332334 0.135128851326416 no 490 0.160485120935317 173 935561 SGTC_3270 9137563 49.47 µM 0.987935468018291 0.136185333646934 no 491 0.161592126822037 176 17015724 SGTC_1588 farnesol 29.9 µM 0.98316194976322 0.137304571288634 no 492 0.162763869282594 183 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_254 nsc-64875 3.808 µM 0.982608589208866 0.137434721832157 no 493 0.162900057724096 163 56993 SGTC_1274 0865-0114 173 µM 0.982343934253776 0.137496998512499 no 494 0.162965218558269 185 870624 SGTC_2764 methyldopa 94.69 µM 0.980523859744122 0.137925807023551 no 495 0.163413798959878 175 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2288 7946289 167.31 µM 0.97893463813096 0.138300972003317 no 496 0.163806138008467 188 1246052 SGTC_495 decylubiquinone 155 µM 0.978735371166347 0.138348061666665 no 497 0.163855375134838 178 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_847 0342-0274 5.54 µM 0.977343552097571 0.138677273362636 no 498 0.164199549265179 200 18097 SGTC_3298 9116858 71.43 µM 0.976260772280045 0.138933755729771 no 499 0.164467627042138 204 2506942 SGTC_1123 mangostin 811.285 nM 0.976132142458192 0.138964246237379 no 500 0.164499492429537 127 5281650 An antioxidant. SGTC_2047 4141938 200 µM 0.975742852031166 0.139056551682902 no 501 0.164595955488977 213 3807862 SGTC_2116 5511452 16.8835 µM 0.974320187983884 0.139394237364992 no 502 0.164948791966351 195 870744 SGTC_614 0462-0418 107 µM 0.972354013095588 0.139861849172248 no 503 0.165437230753492 176 5188303 SGTC_1122 capsaicin 818.572 nM 0.971211953006763 0.140133952220443 no 504 0.165721371410501 189 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_882 0843-0131 351 µM 0.970533960908348 0.140295658142619 no 505 0.165890202703499 210 5425421 SGTC_2426 5582046 32.21 µM 0.968549020335502 0.140769808936967 no 506 0.166385124795601 175 2251934 SGTC_2713 st079149 53.4 µM 0.968141703304083 0.140867240704635 no 507 0.166486802385692 187 3103253 SGTC_1041 0206-0046 107 µM 0.966134902015469 0.141347943003658 no 508 0.1669883409701 195 50494 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.964183836460057 0.141816359343001 no 509 0.1674768832865 193 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1559 coumarin 343 70.1 µM 0.963231737185965 0.142045322776771 no 510 0.167715620739183 177 108770 A hepatotoxic, DNA x-linker. SGTC_2158 5657123 3.6195 µM 0.962800042681954 0.142149220255876 no 511 0.167823939658846 200 2858827 SGTC_1557 sumaresinolic acid 42.3 µM 0.96024706106239 0.142764706911403 no 512 0.168465443321509 173 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.960099922398603 0.14280023472216 no 513 0.168502463766703 189 140250 A respiratory chain inhibitor. SGTC_164 4100-3994 89.624 µM 0.958605659929292 0.14316137490364 no 514 0.168878720082826 216 4615967 SGTC_283 0987-0079 11.7 µM 0.957845240619887 0.14334539318005 no 515 0.169070401261117 188 411556 SGTC_2185 6113692 200 µM 0.956902479783321 0.143573759014961 no 516 0.169308239729818 196 874150 SGTC_2300 7976697 71.57 µM 0.955477341820654 0.143919437456861 no 517 0.169668179168245 164 2236109 SGTC_1963 st076565 50.3 µM 0.95015345710357 0.145215750483879 no 518 0.171017141983413 208 4914280 SGTC_1508 1080-0625 72.9 µM 0.94905278711631 0.145484729707869 no 519 0.171296882590288 183 767111 SGTC_1574 spiramycin 23.7 µM 0.948210211004266 0.145690862829161 no 520 0.171511224961522 213 6419898 An antibiotic and protein synthesis inhibitor. SGTC_754 3474-0146 171 µM 0.947715051353594 0.14581209335734 no 521 0.171637268214782 195 24762078 SGTC_3256 9138902 49.47 µM 0.943920124701318 0.146743460509577 no 522 0.172605233583772 225 17228773 SGTC_3311 9131146 2.8755 µM 0.942577744590702 0.147073866759303 no 523 0.172948463901292 222 4900406 YPR165W RHO1 SGTC_3115 9123671 49.47 µM 0.941201160653993 0.147413209420555 no 524 0.173300891035172 205 3286988 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.941006246599061 0.147461300187903 no 525 0.17335082902806 167 6708630 An antioxidant. SGTC_2952 9073731 13.78 µM 0.940896564379934 0.147488366490813 no 526 0.173378934209741 197 16457353 SGTC_418 lividomycin a 100 µM 0.93991616999067 0.147730446446178 no 527 0.173630281176728 190 72394 An antibiotic. SGTC_2820 7989630 71.43 µM 0.935829395842245 0.148742421914255 no 528 0.174680516909772 151 2984098 SGTC_346 4513-0042 7.16 µM 0.935526450447116 0.148817621903043 no 529 0.174758529283649 198 2827372 SGTC_925 2064-1272 59.6 µM 0.933771339859277 0.149253792088527 no 530 0.175210928186421 202 6815817 SGTC_1413 3910-0535 34.4 µM 0.929951037844507 0.150206140468934 no 531 0.176198217883425 196 2876951 SGTC_797 k781-0471 270 µM 0.929848522466654 0.150231751809609 no 532 0.176224759594048 215 23738129 SGTC_2137 5261020 140 µM 0.929197551111134 0.150394451416189 no 533 0.176393358164556 180 763655 SGTC_832 4083-0019 164 µM 0.929074896597465 0.150425120037865 no 534 0.176425136537958 220 1990758 SGTC_1187 1391-0724 117 µM 0.926120694953199 0.151165049446753 no 535 0.177191630102882 188 6997986 SGTC_2486 5283202 22.39 µM 0.924252682063659 0.15163417220318 no 536 0.177677386258465 195 1377751 SGTC_3000 9075062 71.4286 µM 0.924003463344176 0.151696832743882 no 537 0.177742256307391 192 17057871 SGTC_2115 tiliquinol 12.7705 µM 0.923539759545651 0.151813466610837 no 538 0.177862995218344 203 71208 A bioactive hydroxyquinoline. SGTC_1555 citronellol 128 µM 0.92323921415025 0.151889093606979 no 539 0.17794127866746 201 8842 A terpine precursor. SGTC_2452 5863136 48.41 µM 0.922831994696028 0.151991603190563 no 540 0.178047382306363 211 2184096 SGTC_1562 morin hydrate 59.1 µM 0.922197452378673 0.152151428459903 no 541 0.178212795861958 196 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3161 9100388 49.47 µM 0.921922987141124 0.152220593920743 no 542 0.17828437391861 214 25236368 SGTC_3027 9089541 49.47 µM 0.921781071030045 0.152256365081158 no 543 0.178321391464034 204 9943819 SGTC_1348 1493-0373 93.8 µM 0.919990786745872 0.152708100667387 no 544 0.178788786921668 232 3010129 SGTC_622 1348-1566 26.3 µM 0.919578904895758 0.152812154904963 no 545 0.178896427308656 202 7340407 SGTC_1228 0124-0032 52.5 µM 0.918995664715664 0.152959580031523 no 546 0.17904891989532 192 X1228 SGTC_3184 9108758 49.47 µM 0.918870483969493 0.15299123414994 no 547 0.179081660011857 201 902885 SGTC_2662 daunorubicin 22.37 µM 0.918548546651743 0.153072661517691 no 548 0.179165877680498 202 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3121 9125696 49.47 µM 0.918307711316354 0.153133594600726 no 549 0.179228895642486 212 1235365 SGTC_3289 9119912 71.43 µM 0.914272602103325 0.154156897300322 no 550 0.180286811605363 209 17014829 SGTC_763 3453-1109 128 µM 0.913494666709308 0.154354700399186 no 551 0.180491218644062 209 1560353 SGTC_2933 9026794 32.47 µM 0.913465053008099 0.154362233492825 no 552 0.18049900268709 200 17586027 SGTC_2642 cholecalciferol 100 µM 0.913130160073426 0.154447440026761 no 553 0.180587044873419 192 9821465 A vitamin D precursor, similar to steriods. SGTC_199 4063-0024 41.6 µM 0.912399138932233 0.154633541126755 no 554 0.180779321325427 191 306215 SGTC_2388 9080168 200 µM 0.910479279431792 0.155122998385009 no 555 0.181284902197646 230 15943073 SGTC_1107 amlodipine 47 µM 0.910240939643994 0.155183833052916 no 556 0.181347728953866 180 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_603 3794-0023 45.9 µM 0.90831997445497 0.155674721759548 no 557 0.181854596138843 212 3802260 SGTC_1522 st012842 45.6 µM 0.907526026922109 0.155877908064604 no 558 0.182064346224587 214 3491067 YOR116C RPO31 SGTC_2965 9082772 38.63 µM 0.90573001814835 0.156338185728372 no 559 0.182539384980101 141 16459634 SGTC_671 0560-0003 407 µM 0.90422337198208 0.156724995871838 no 560 0.182938484743004 179 3238678 SGTC_515 4092-1064 102 µM 0.903778314363122 0.156839378547779 no 561 0.183056481419366 217 717353 SGTC_2056 5235370 200 µM 0.90364909604975 0.156872598774021 no 562 0.183090749542311 197 5511916 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.903436948768025 0.156927148920806 no 563 0.18314701873737 218 756377 SGTC_2165 5727197 32.143 µM 0.903109926268466 0.157011261763071 no 564 0.183233778156347 216 1361712 SGTC_1330 1469-0054 61.8 µM 0.902807115103117 0.157089173692819 no 565 0.183314137133825 209 7102664 SGTC_1560 lithocholic acid 53.1 µM 0.901566825818533 0.15740855978194 no 566 0.183643510090438 196 9903 A bile acid which acts as a detergent. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.900905418015059 0.157579052845417 no 567 0.183819305133527 209 5357218 A potent inhibitor of glutathione S-transferases. SGTC_726 3448-4391 34.2 µM 0.899506712170801 0.157940000892582 no 568 0.184191411097332 216 1356692 SGTC_1878 temozolomide 1 mM 0.895489626886484 0.158979660298866 no 569 0.185262704214873 201 5394 DNA alkylating agent. SGTC_3159 9100096 49.47 µM 0.893631836268762 0.159461987055957 no 570 0.185759453383378 194 25236875 SGTC_2014 4013930 200 µM 0.893567891944624 0.159478605563568 no 571 0.185776565963584 220 64556 SGTC_502 l-744,832 89.3 µM 0.893298788309702 0.159548555404566 no 572 0.185848593353696 206 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2046 4110841 106 µM 0.892316065121404 0.159804171517565 no 573 0.186111772874951 220 44119630 YMR134W ERG29 SGTC_1932 st074806 40.9 µM 0.891404604350052 0.160041490907969 no 574 0.186356074245195 241 17251235 SGTC_1981 st071826 47 µM 0.891185994183566 0.160098445248435 no 575 0.186414698463511 209 11838600 SGTC_834 0312-0008 75.7 µM 0.887824096961325 0.16097598647565 no 576 0.18731768938397 204 6385573 YIL048W NEO1 SGTC_2697 mebhydrolin 72.4 µM 0.887332950790692 0.16110445053137 no 577 0.187449835127347 208 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2567 aureobasidin a 60 nM 0.88570055367148 0.16153190038634 no 578 0.187889454946402 238 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_569 4130-2812 160 µM 0.884580164333903 0.161825706429069 no 579 0.188191554392421 202 743552 SGTC_3326 9140064 16.379 µM 0.883792372616384 0.162032501881152 no 580 0.18840415227783 205 1868434 SGTC_2757 clomiphene 4.22 µM 0.881601706435492 0.162608456480157 no 581 0.188996116003963 236 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1784 st039334 36.3 µM 0.880418213370218 0.162920165650644 no 582 0.189316396687837 238 3496984 SGTC_2122 5258151 111.688 µM 0.879456987343063 0.163173619700884 no 583 0.18957677248186 203 2173356 SGTC_2239 6685329 187.64 µM 0.876994272233315 0.163824151789267 no 584 0.190244874580432 185 805680 SGTC_1399 3562-5772 25 µM 0.876695411413646 0.163903210960768 no 585 0.190326049879854 206 23847490 SGTC_1891 st059073 26.2 µM 0.875844097938707 0.164128548921933 no 586 0.190557396600347 229 688754 SGTC_2377 9073351 62.6 µM 0.874456229923392 0.164496340509627 no 587 0.190934923411846 223 7337946 YHR072W ERG7 SGTC_1039 k821-0043 94 µM 0.873949170439421 0.164630846802208 no 588 0.191072967706011 201 15992768 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.87313978689343 0.164845697404517 no 589 0.191293444927536 224 688803 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.873036866776963 0.164873030525168 no 590 0.191321491683475 211 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3026 9090633 49.47 µM 0.871667539173279 0.165236970474283 no 591 0.191694886878635 225 25236842 SGTC_1800 st050079 29.0735 µM 0.870742398750746 0.165483148404142 no 592 0.191947411295214 217 3645560 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.870015747415967 0.165676675073591 no 593 0.192145899239458 222 6708784 An antioxidant flavonoid SGTC_664 1222-0054 14.9 µM 0.869081318325998 0.165925753516363 no 594 0.192401327062372 214 6813991 SGTC_2988 9073640 71.4286 µM 0.86826279012308 0.166144136531152 no 595 0.192625243680957 217 9102229 SGTC_1328 1441-0025 69.2 µM 0.868220959674828 0.166155301863662 no 596 0.192636691096544 199 4562601 SGTC_2656 pseudo-anisatin 100 µM 0.866630282248377 0.166580243206704 no 597 0.193072307956566 242 6708809 A neurotoxin. SGTC_276 colchicine 750 µM 0.864970065181841 0.167024509158813 no 598 0.193527609577924 220 2833 A microtubule depolymerizer. SGTC_2401 5128683 200 µM 0.864352137943472 0.167190058396321 no 599 0.193697238419568 216 708373 SGTC_401 neomycin 50 µM 0.856643701412938 0.169264115518798 no 600 0.195820912980432 204 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3305 9127027 53.8275 µM 0.855059151131766 0.169692497774469 no 601 0.196259201107586 223 41905295 SGTC_1790 st045711 43.5 µM 0.851860605234681 0.170559339380061 no 602 0.197145732066497 178 585119 SGTC_3206 9114350 49.47 µM 0.851303077732885 0.17071072521257 no 603 0.19730050784504 210 17087243 SGTC_1293 1000-1278 195 µM 0.85105178782848 0.17077898624581 no 604 0.197370292715124 229 678847 SGTC_2493 resveratrol 26.09 µM 0.850629309486441 0.170893788711235 no 605 0.197487651388415 191 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1792 st045773 43.6 µM 0.848311602799407 0.17152447067575 no 606 0.198132228754314 171 2919270 SGTC_3263 9137018 49.47 µM 0.84416169161304 0.172657432863801 no 607 0.199289529053843 231 43844957 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.843222074350247 0.172914617552972 no 608 0.199552127510476 217 61125 An anti-inflammatory. SGTC_2264 7948757 110.76 µM 0.842806095923647 0.173028553831103 no 609 0.199668449078112 221 2971411 SGTC_3268 9137683 49.47 µM 0.842710740808402 0.173054678285085 no 610 0.199695119324285 281 1953228 SGTC_2213 7173844 200 µM 0.841631995107352 0.173350397375374 no 611 0.199996987193796 229 892728 SGTC_2387 9077560 195.08 µM 0.841265823837668 0.173450849856668 no 612 0.200099516072817 222 5303272 SGTC_185 k048-0037 25.491 µM 0.840466792459729 0.17367017830605 no 613 0.200323356540756 210 6827589 SGTC_2587 piperic acid 92.2 µM 0.839982997502683 0.173803062315441 no 614 0.200458959839379 216 5370536 SGTC_3299 9121982 43.1275 µM 0.839851295675172 0.173839248065505 no 615 0.200495884201194 215 17594604 YPL160W CDC60 SGTC_619 1652-1634 108 µM 0.839710399251377 0.173877965382439 no 616 0.200535390912664 222 5400454 SGTC_315 k915-0449 187 µM 0.839123666512821 0.174039254250396 no 617 0.200699958343576 228 20970215 YNL149C PGA2 SGTC_2463 5473429 200 µM 0.835502297194983 0.175036848397499 no 618 0.201717477034458 219 5399405 SGTC_2526 patulin 37.61 µM 0.831341166449601 0.176187602657474 no 619 0.202890462532021 237 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_884 0851-0618 334 µM 0.829473758825151 0.176705584415967 no 620 0.203418189791196 244 9642473 SGTC_132 0417-1715 25.805 µM 0.829366950348316 0.176735240045115 no 621 0.203448398483235 224 6769098 SGTC_1426 4048-4480 71.7 µM 0.827078879504854 0.177371283928421 no 622 0.204096177176291 218 14224343 SGTC_1182 1222-0449 220 µM 0.82699246036336 0.177395335235625 no 623 0.204120667465088 235 658318 SGTC_3148 9097893 49.47 µM 0.826739423468657 0.177465769761835 no 624 0.204192385563187 208 17174100 SGTC_3171 9103192 49.47 µM 0.82648578869385 0.177536388425472 no 625 0.20426428817599 245 13018434 SGTC_2634 4'-methoxyflavone 100 µM 0.823987432080554 0.178232944857253 no 626 0.204973349553774 196 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2517 totarol 10 µM 0.821929016111042 0.178808135572094 no 627 0.205558648835828 219 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1741 st038134 10.228 µM 0.817908894182604 0.17993485803371 no 628 0.20670460564841 210 1272587 SGTC_2176 5809774 33.9695 µM 0.817755269387399 0.179978002828223 no 629 0.20674847210952 204 2870539 SGTC_190 3970-0790 3.722 µM 0.817041471197796 0.180178554866354 no 630 0.206952364363315 221 2832352 SGTC_1344 1488-0097 29.1 µM 0.816049890554264 0.180457386624495 no 631 0.20723580091887 257 747966 SGTC_506 n9-isopropylolomoucine 153 µM 0.815350440398465 0.180654234223798 no 632 0.207435871981115 220 6610355 SGTC_2251 lansoprazole 556 µM 0.814275567215656 0.18095700017801 no 633 0.207743551678762 213 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2024 5144227 134 µM 0.81366712120446 0.181128525661042 no 634 0.207917837215695 215 3475211 SGTC_1955 wogonin 32.4 µM 0.812063605976264 0.181581056297873 no 635 0.20837756746215 212 5281703 A flavanone. SGTC_2126 5251174 33.877 µM 0.811806039605146 0.18165381042117 no 636 0.20845146797934 224 790722 SGTC_2783 7738165 71.43 µM 0.810952758533093 0.181894964858397 no 637 0.208696400364876 243 17201110 SGTC_1365 1672-3266 55.4 µM 0.81019097727304 0.182110428690823 no 638 0.208915211188221 244 6415873 SGTC_843 0310-0051 143 µM 0.809148712804649 0.182405483357431 no 639 0.209214805666382 242 2065037 SGTC_2290 7904846 200 µM 0.808940567126482 0.182464443078845 no 640 0.209274666537912 228 2962154 SGTC_2040 5100729 123 µM 0.808862942615604 0.182486434185621 no 641 0.209296993247059 237 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1057 3448-5381 134 µM 0.808640906018359 0.182549346530647 no 642 0.209360864146464 223 5497911 SGTC_2926 9010726 65.15 µM 0.808137629156986 0.182691996261856 no 643 0.209505678890477 232 2994293 SGTC_3317 9138495 8.753 µM 0.803762040103947 0.183935152710263 no 644 0.21076720826056 247 17020139 SGTC_1815 st051655 58.2 µM 0.803398345738354 0.184038719156493 no 645 0.210872265439323 238 5984156 SGTC_441 propafenone 146 µM 0.803194059192591 0.184096908184896 no 646 0.210931289355227 255 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2643 anethole 100 µM 0.803165087622918 0.18410516138091 no 647 0.210939660810577 261 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_626 0214-0009 33 µM 0.801372123140371 0.184616375322239 no 648 0.211458124308558 243 3437874 SGTC_1919 st067113 52.3 µM 0.798041197141942 0.185568436607272 no 649 0.212423291701939 254 1268243 SGTC_1959 st077091 55.8 µM 0.796966631705674 0.18587622291449 no 650 0.212735205485856 256 821356 YKL052C ASK1 SGTC_2731 amoxapine 43.43 µM 0.796500736317493 0.186009767022822 no 651 0.212870523856343 283 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_378 3970-0959 8.33 µM 0.788817067895025 0.188220784075223 no 652 0.215109466179512 245 6615653 SGTC_2673 kobusone 100 µM 0.7865286846155 0.188882400081853 no 653 0.21577891047581 277 6710676 An epoxy ketone and protein crosslinker. SGTC_2283 7944793 200 µM 0.786133122826764 0.188996909756359 no 654 0.21589475052157 240 2970533 SGTC_3082 9117008 49.47 µM 0.784533468667833 0.189460423542944 no 655 0.216363575710477 244 41448529 SGTC_3321 9137793 26.8275 µM 0.782257986389117 0.190120968540621 no 656 0.217031486255587 242 4904192 SGTC_3092 9117248 49.47 µM 0.781743537865959 0.190270502640198 no 657 0.217182654643105 262 17141857 SGTC_1993 st073995 70.8 µM 0.780461893767343 0.190643350596637 no 658 0.217559524416283 240 3098394 SGTC_1407 3909-7909 12.3 µM 0.77506124698438 0.192219394052962 no 659 0.219151734717566 233 4411780 SGTC_2845 9003024 42.97 µM 0.773366870650056 0.192715493172373 no 660 0.219652645357712 236 2990173 SGTC_3114 9122766 49.47 µM 0.773011156272839 0.192819742625376 no 661 0.219757889091786 220 17176985 SGTC_253 dyclonine 31.25 µM 0.772631908571332 0.192930926942887 no 662 0.219870127411081 222 3180 An oral anasthetic. SGTC_2779 methotrexate 400 µM 0.772262078548305 0.193039387974377 no 663 0.219979610247115 251 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1683 st010134 710 nM 0.772244881369765 0.193044432342247 no 664 0.219984701984372 238 3818134 SGTC_295 k015-0027 31 µM 0.7719618698665 0.193127458342462 no 665 0.220068505687663 245 3887424 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.770599813637632 0.193527344397463 no 666 0.220472085850594 279 5282309 SGTC_2860 9025725 38.96 µM 0.770344539985573 0.193602346340584 no 667 0.220547771145989 230 40546248 SGTC_2043 5101342 149 µM 0.770027735767574 0.193695451224251 no 668 0.220641720147304 251 678451 SGTC_2481 5478948 45.16 µM 0.76845888413657 0.194156919746113 no 669 0.221107304353974 234 77792 SGTC_3167 9103034 49.47 µM 0.768319712417603 0.194197888605162 no 670 0.221148633128144 232 5127859 SGTC_3336 9143619 71.43 µM 0.767763603030289 0.194361646589146 no 671 0.221313820841207 236 45595730 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.766922715683023 0.194609422990876 no 672 0.221563733475171 247 2374 Ca(2+)-ATPase inhibitor. SGTC_1965 Pectolinarigenin 58.4 µM 0.766108811989251 0.194849431336988 no 673 0.221805780081074 259 5320438 An anti-inflammatory. SGTC_538 2922-0838 53.3 µM 0.764967863669144 0.195186183281637 no 674 0.22214534054439 232 777039 SGTC_2724 maprotiline 69.64 µM 0.761824750344129 0.196115703727161 no 675 0.223082303200536 250 4011 A tricyclic antidepressant. SGTC_806 3966-4455 5.86 µM 0.761543819044716 0.196198914711566 no 676 0.223166158286674 250 714982 SGTC_2350 9023895 38.85 µM 0.76009625857131 0.196628016916612 no 677 0.223598524459155 240 2997209 SGTC_629 3448-6466 76.7 µM 0.756916246359188 0.19757266619674 no 678 0.22455002070042 263 573744 SGTC_1233 0325-0408 14.2 µM 0.756382820815657 0.197731392998308 no 679 0.224709852450847 246 12874 SGTC_466 geldanamycin 89.2 µM 0.755785614021359 0.19790919003431 no 680 0.22488887168099 225 5288382 HSP90 inhibitor. SGTC_2946 9065502 71.43 µM 0.753722880326248 0.198524037909484 no 681 0.225507820027294 209 16489101 SGTC_2096 5468907 200 µM 0.753532296411263 0.19858090416518 no 682 0.22556505566787 240 759785 SGTC_2897 9048598 12.99 µM 0.753164244192995 0.198690751056069 no 683 0.225675611369571 251 6467404 SGTC_1781 st038725 66.3 µM 0.75287021387334 0.198778532090572 no 684 0.225763954362189 264 4270275 YIL048W NEO1 SGTC_641 4092-0595 30 µM 0.752848463106188 0.198785026583698 no 685 0.225770490274252 245 786260 SGTC_2168 5727979 200 µM 0.751266684112879 0.199257667850911 no 686 0.226246087609678 247 695210 SGTC_118 0083-0097 135.343 µM 0.750759143858665 0.199409466010926 no 687 0.226398810833728 289 5207356 SGTC_638 3970-0837 4.09 µM 0.749666795717773 0.199736408074415 no 688 0.226727705195668 246 4118451 YLR208W SEC13 SGTC_2032 5185112 25.99 µM 0.749471558467053 0.199794876939319 no 689 0.226786517434688 229 5718189 SGTC_1603 st002045 67.8 µM 0.748084955316213 0.200210427393869 no 690 0.227204458007228 256 5887985 SGTC_561 1550-0330 72.9 µM 0.743478369697098 0.201594697437424 no 691 0.228596056200935 247 6812934 SGTC_2125 5246583 200 µM 0.742194613419297 0.201981482907658 no 692 0.228984715864909 263 835267 SGTC_1154 4088-0362 150 µM 0.741720194230061 0.202124533936936 no 693 0.229128440952994 256 6618304 SGTC_1065 prochlorperazine maleate 2.48 µM 0.740700755566225 0.202432129031332 no 694 0.229437450566614 281 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_919 tnp00227 403.569 nM 0.74047591706396 0.202500007177478 no 695 0.229505634455301 268 1269246 A methoxyflavone. YNL221C POP1 SGTC_3319 9138450 16.7555 µM 0.74013279831414 0.20260362003981 no 696 0.229609709559077 250 2029690 SGTC_2585 alliin 100 µM 0.739056937701482 0.202928707112546 no 697 0.229936211975849 256 87310 A garlic compound which reacts with lipids. SGTC_972 1319-0219 195 µM 0.737176489577543 0.203497659700206 no 698 0.230507514366025 272 23903702 SGTC_2161 5662504 8.5105 µM 0.735486724817115 0.204009729483814 no 699 0.231021560953092 250 2859334 SGTC_74 000s-0487 160.283 µM 0.734111367721482 0.204427086704839 no 700 0.231440432915243 239 677548 SGTC_3080 9117754 49.47 µM 0.734069028104693 0.204439942877093 no 701 0.231453334375102 255 9550191 SGTC_2787 5284540 71.43 µM 0.73396480189196 0.204471592595651 no 702 0.23148509523498 270 736958 SGTC_636 0kpi-0074 126 µM 0.733393328213668 0.204645180236974 no 703 0.231659283622461 266 616434 SGTC_651 3253-0966 34.4 µM 0.732136619781688 0.205027219203641 no 704 0.232042592222505 261 781462 SGTC_3172 9105863 49.47 µM 0.732053134794572 0.205052613621291 no 705 0.232068068477271 257 2348785 SGTC_2653 dihydrofissinolide 100 µM 0.730243945295668 0.205603390999064 no 706 0.23262054257084 258 6857746 SGTC_1758 st042942 75.2445 µM 0.729809398730526 0.205735812090828 no 707 0.232753349325698 257 669317 SGTC_888 0916-0002 6.97 µM 0.729275525277437 0.205898570727483 no 708 0.232916570175572 242 2802138 YIL048W NEO1 SGTC_80 0159-0065 512.242 µM 0.729213003685152 0.205917636286572 no 709 0.232935689027147 246 1548079 SGTC_1780 st038448 24.544 µM 0.728770472381813 0.206052613309047 no 710 0.233071038238573 267 728868 YDL195W SEC31 SGTC_2127 5253358 187.912 µM 0.728386699114692 0.206169710939189 no 711 0.233188451518053 246 20612 SGTC_584 0986-0246 15.4 µM 0.728073649147349 0.206265258551022 no 712 0.233284251710086 287 53315 YDR232W HEM1 SGTC_2112 5488546 200 µM 0.727747357861048 0.206364875544377 no 713 0.233384127280248 269 600757 SGTC_667 1498-1044 59 µM 0.726755446174081 0.206667882000663 no 714 0.233687890411659 286 6739982 SGTC_1886 st057356 49.9 µM 0.726567774883303 0.206725240935721 no 715 0.23374538753382 246 24207747 SGTC_523 1934-0222 13.7 µM 0.726524161461541 0.206738572078202 no 716 0.23375875056312 280 1361595 SGTC_1719 st032227 49.2 µM 0.725876125867466 0.206936714523312 no 717 0.233957356721117 256 3125804 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.725759532588878 0.206972375844356 no 718 0.233993099466891 261 688662 SGTC_2155 5570423 76 µM 0.725622458386285 0.207014306129157 no 719 0.234035124697215 263 797402 SGTC_1950 st077106 7.18 µM 0.724920837927357 0.207229006867175 no 720 0.234250298175019 245 13831864 SGTC_2600 tangeritin 87.95 µM 0.724619126799711 0.207321373045378 no 721 0.23434286082663 264 68077 A bioactive flavone. SGTC_1864 st057645 30.4 µM 0.723688993042705 0.207606278379192 no 722 0.234628346058053 267 688666 SGTC_372 0155-0182 15.9 µM 0.723366766872269 0.207705032042969 no 723 0.234727291525039 237 771486 SGTC_2235 salicylic acid 500 µM 0.72282005652898 0.207872647544107 no 724 0.234895221746563 260 338 A COX inhibitor and kinase inhibitor. SGTC_1971 st069429 63.5 µM 0.721689281051063 0.208219584477163 no 725 0.235242766859505 262 1246522 YGL099W LSG1 SGTC_2857 9024691 58.44 µM 0.721472438951234 0.208286153532437 no 726 0.235309445951151 264 16478292 SGTC_432 NS 1619 61.3 µM 0.720872018104544 0.208470544166913 no 727 0.235494130197148 256 4552 A K+/calcium channel activator. SGTC_1468 k284-1086 134 µM 0.719638683994583 0.208849605741984 no 728 0.235873743834092 258 15996457 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.71942041162006 0.208916733377176 no 729 0.235940962016876 272 5355888 SGTC_1764 st044502 93.5 µM 0.715633304274776 0.210083444965691 no 730 0.237108901738858 252 8407 SGTC_2273 7815444 169.05 µM 0.715508216579087 0.210122046499417 no 731 0.237147532766045 278 2824616 SGTC_1456 k015-0012 13 µM 0.715175301720015 0.210224802915535 no 732 0.237250364225001 269 2989616 SGTC_1419 3993-2473 62.6 µM 0.714921332017583 0.210303212217521 no 733 0.237328827399173 278 704026 SGTC_1622 st003707 19.4 µM 0.713021384358176 0.210890336839317 no 734 0.237916262315991 239 10140899 SGTC_3243 9134147 49.47 µM 0.712337626584205 0.211101867640644 no 735 0.238127864737078 274 24282180 SGTC_1162 k048-0130 20.1 µM 0.711308743013945 0.211420402556215 no 736 0.238446467446894 263 6797406 SGTC_2607 solasodine 47.35 µM 0.70938923137774 0.212015421350137 no 737 0.239041484237979 280 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3065 9113888 49.47 µM 0.708484482105309 0.212296218830199 no 738 0.23932222272215 263 16648368 SGTC_141 0443-0274 32.331 µM 0.707954636217164 0.212460762369944 no 739 0.239486714432537 238 1627241 SGTC_2560 caryophyllene 100 µM 0.707203930100402 0.212694021530805 no 740 0.239719878296855 271 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2049 5262831 67.185 µM 0.706631035960855 0.212872131567919 no 741 0.23989789835817 269 763417 SGTC_2416 tofa 880 nM 0.70313702585775 0.213960285407945 no 742 0.240985179881395 258 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1284 0929-0043 16 µM 0.702846632095047 0.214050869437965 no 743 0.2410756663674 261 1239883 SGTC_752 1896-0090 130 µM 0.700761030060449 0.214702097578357 no 744 0.241726080901462 264 772567 SGTC_3147 9097027 49.47 µM 0.700700327508607 0.214721069145504 no 745 0.241745025814648 297 25236841 SGTC_1430 4049-0248 69.1 µM 0.700109283972941 0.214905840826794 no 746 0.241929529177939 277 22774488 SGTC_2572 astragaloside iv 100 µM 0.699719544291023 0.215027731527137 no 747 0.242051234216912 266 45006101 An anti-inflammatory agent. SGTC_549 1661-1316 519 µM 0.698706172157892 0.215344850484617 no 748 0.242367837946861 282 2857282 SGTC_2294 7971431 200 µM 0.697252629381524 0.215800187394199 no 749 0.242822353870799 297 5741572 SGTC_2648 atorvastatin 78.68 µM 0.696785674988378 0.215946583903479 no 750 0.242968466127321 271 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1298 1079-1278 263 µM 0.695383883981791 0.216386409812807 no 751 0.243407378770548 271 2840950 SGTC_645 0845-0943 5.41 µM 0.694648073024923 0.216617485189463 no 752 0.243637938759331 251 1885106 SGTC_639 0833-0042 114 µM 0.693721813185638 0.216908572313867 no 753 0.243928341836708 293 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_266 formosanin C 406 nM 0.693622543052156 0.216939782431257 no 754 0.243959476310161 266 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2601 securinine 100 µM 0.691764571070089 0.217524399847194 no 755 0.244542594591444 298 442872 A GABA receptor antagonist. SGTC_223 busulfan 5 mM 0.691551229541623 0.217591586662631 no 756 0.244609599135707 268 2478 A DNA alkylator. SGTC_349 k015-0014 24 µM 0.6909043348519 0.217795383881437 no 757 0.244812830905006 273 2196908 SGTC_1319 1306-0155 43.7 µM 0.690273271279097 0.217994299728726 no 758 0.245011176634666 283 3122360 SGTC_116 0155-0182 31.788 µM 0.689847189172217 0.218128663134629 no 759 0.24514514476911 241 771486 SGTC_971 1315-0384 26.7 µM 0.689095588349728 0.218365793979311 no 760 0.24538155803928 285 6769120 SGTC_1518 st038567 90.8 µM 0.689025700552622 0.218387851195552 no 761 0.245403547213214 297 77966 SGTC_649 1123-0311 367 µM 0.688147122813783 0.218665247669921 no 762 0.245680069168153 270 693629 YIL048W NEO1 SGTC_27 0485-0001 32.618 µM 0.687634271124889 0.218827265861898 no 763 0.245841560481426 266 2054479 SGTC_1825 st052143 62.6 µM 0.687587423483819 0.218842069236052 no 764 0.245856315124012 276 674173 SGTC_175 3793-3120 23.7 µM 0.687286009748533 0.21893732666358 no 765 0.245951256604021 299 5322297 SGTC_577 r071-0003 38.6 µM 0.686971406216551 0.219036777969281 no 766 0.246050373681421 296 4568517 YMR134W ERG29 SGTC_3181 9108277 49.47 µM 0.686417309210799 0.219212000225472 no 767 0.246224996209456 290 17097298 SGTC_2298 7976326 193.81 µM 0.684619694736027 0.219781014798179 no 768 0.246791967892221 250 2235818 SGTC_823 0417-1665 178 µM 0.683019289590888 0.220288317676598 no 769 0.247297326834172 289 3429856 SGTC_1759 st043059 70 µM 0.681881313921089 0.220649445837872 no 770 0.247657000977977 294 669426 SGTC_2095 5432005 200 µM 0.679534986593141 0.221395104928684 no 771 0.248399473673464 292 783734 SGTC_93 0109-0045 59.227 µM 0.67938005026021 0.221444394110065 no 772 0.248448543508282 284 88733 SGTC_2568 diosmetin 100 µM 0.677427006061287 0.22206624479898 no 773 0.249067534221328 293 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_4 0960-0234 25.671 µM 0.676969900284965 0.222211931436745 no 774 0.249212526053609 264 6821112 SGTC_2321 7390090 138.78 µM 0.676900240588801 0.222234137840943 no 775 0.249234625726898 284 649046 SGTC_2369 9071472 200 µM 0.675865586040882 0.222564118318405 no 776 0.249562994537658 284 17296037 SGTC_597 k018-0003 82.8 µM 0.674402545426628 0.223031199630858 no 777 0.250027712447721 290 6786234 SGTC_1874 staurosporine 7.6 µM 0.674168923467337 0.223105835988664 no 778 0.250101962248166 278 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_750 4073-0104 132 µM 0.673520350680261 0.223313113258127 no 779 0.250308153139436 258 22330957 SGTC_3320 9137005 35.139 µM 0.672398090500887 0.223672034959414 no 780 0.250665149051145 270 4908713 SGTC_2285 7945142 200 µM 0.671627477647973 0.223918682499279 no 781 0.250910440471225 289 2970608 SGTC_1847 st056231 15 µM 0.670501369152482 0.224279390164179 no 782 0.251269116970646 271 5393180 SGTC_2089 5281248 129.67 µM 0.669686969036286 0.224540458879518 no 783 0.25152868015094 274 2737878 SGTC_251 melphalan 456.522 µM 0.666366731456285 0.225606595642968 no 784 0.252588360830168 289 460612 A DNA alkylator. SGTC_1632 st005650 90 µM 0.666127130920124 0.225683642643675 no 785 0.252664922157396 275 2759605 SGTC_2716 st080858 38.6235 µM 0.665413767320228 0.225913123094699 no 786 0.252892940837924 270 5296050 SGTC_3035 9091303 49.47 µM 0.665198497792327 0.225982398607077 no 787 0.252961770597394 291 25237002 SGTC_892 0929-0076 29 µM 0.665029816957542 0.226036689884267 no 788 0.253015711088523 275 5751038 SGTC_342 k048-0088 23.3 µM 0.664442423466068 0.226225804711195 no 789 0.253203594072331 283 6820570 SGTC_2034 5197015 53.07 µM 0.662313392709951 0.226912007528612 no 790 0.253885197733979 290 780676 SGTC_595 3909-8003 73.7 µM 0.661614295159535 0.227137587766836 no 791 0.254109221843895 295 699517 SGTC_361 000s-0510 1.45 µM 0.659655495619984 0.227770313275268 no 792 0.254737466222674 281 660 SGTC_1805 st050013 60.3 µM 0.656689179292924 0.228730369657636 no 793 0.255690396761525 283 4037144 SGTC_1062 mesoridazine 14.2 µM 0.656659595699802 0.228739955896939 no 794 0.255699909870718 274 4078 A neuroleptic. SGTC_3232 9132874 49.47 µM 0.65641091011307 0.228820548654486 no 795 0.255779886270695 271 3784940 SGTC_663 1486-0733 13.9 µM 0.656373107850424 0.228832800814533 no 796 0.255792044487133 288 722445 YPR165W RHO1 SGTC_724 3910-0327 137 µM 0.654725213116051 0.229367260746667 no 797 0.256322344487599 307 2885483 SGTC_478 N-arachidonylglycine 10 µM 0.654233769708977 0.229526785407092 no 798 0.256480604060011 248 5283389 SGTC_2076 5212012 200 µM 0.653855611444624 0.229649579530037 no 799 0.25660241705387 278 604802 SGTC_611 3453-1652 23.7 µM 0.653497125027455 0.229766019853354 no 800 0.256717921132009 298 1560575 SGTC_53 0973-0023 39.979 µM 0.653126797807704 0.229886340908142 no 801 0.256837268726388 301 674768 SGTC_2612 dictamnine 15.46 µM 0.652159558419304 0.230200767845779 no 802 0.257149122969168 277 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1695 st026914 34.495 µM 0.651410358712276 0.230444480410347 no 803 0.257390812800833 283 3289191 SGTC_1476 4112-3294 3.34 µM 0.650719016333301 0.230669500047024 no 804 0.25761394268141 280 704369 SGTC_318 1488-0629 67.2 µM 0.649904088605589 0.230934902076923 no 805 0.257877088500791 302 3662576 SGTC_2516 gossypol 71.55 µM 0.648995473246315 0.231231016786272 no 806 0.258170651068797 293 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1915 st067105 30.6 µM 0.648545290473739 0.231377808286345 no 807 0.258316163805361 292 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2563 tomatine 8.54 µM 0.64761156471909 0.231682434691708 no 808 0.258618107751733 327 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1155 4088-0394 48.2 µM 0.647392477158553 0.231753943985985 no 809 0.258688981741044 291 2326248 SGTC_1750 st081859 2.357 µM 0.647120083224496 0.231842869411565 no 810 0.258777114158243 289 5291695 SGTC_1619 st003326 88.7 µM 0.646696797358124 0.231981092559294 no 811 0.258914098134206 252 2849032 SGTC_2100 5377183 190 µM 0.645049260280584 0.232519529120332 no 812 0.259447631808143 278 2844202 SGTC_760 0568-0725 82.9 µM 0.644088630629226 0.232833795830455 no 813 0.259758981234192 289 3916171 SGTC_98 0074-0023 107.663 µM 0.643626426605254 0.232985088348008 no 814 0.259908854734488 283 3563821 SGTC_1031 k035-0009 16 µM 0.641603756540002 0.233647807614547 no 815 0.260565246635611 294 5180959 SGTC_2312 7706453 155.7 µM 0.641099308810081 0.233813250457881 no 816 0.260729081630573 285 976098 SGTC_1011 4112-3381 17.4 µM 0.641002139654669 0.23384512631225 no 817 0.26076064640549 304 2877139 SGTC_3042 9091578 49.47 µM 0.638842432502969 0.234554228665364 no 818 0.261462720537422 273 25236497 SGTC_1146 3579-1023 7 µM 0.638664186469013 0.234612805741352 no 819 0.261520707800247 307 X1146 SGTC_2871 9038510 12.99 µM 0.638377768868879 0.234706948231666 no 820 0.261613899422857 311 4945164 SGTC_1960 st011366 51.8 µM 0.634339040937987 0.23603665758246 no 821 0.262929791506767 303 3972846 SGTC_2019 4016004 108 µM 0.634212858155045 0.236078268719844 no 822 0.262970958631331 294 45595336 SGTC_853 0419-0306 21 µM 0.633796248443499 0.236215682275305 no 823 0.263106900915651 294 762713 SGTC_1787 fluconazole 80 µM 0.63312686435831 0.23643656254933 no 824 0.263325400190913 277 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_825 1988-2224 89.6 µM 0.632833057380915 0.236533547509692 no 825 0.263421333443248 291 1180859 SGTC_2495 cafestol 54.53 µM 0.632825458930912 0.236536056029717 no 826 0.263423814710234 304 16667697 An anti-infammatory. SGTC_1097 itavastatin 7.23 µM 0.631762656663049 0.236887069248814 no 827 0.263770989336306 291 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1049 3226-0134 66 µM 0.630796738431907 0.237206332687418 no 828 0.264086718130519 289 5702385 SGTC_2751 anetholtrithion 17.25 µM 0.629497116745193 0.237636267307431 no 829 0.26451182786742 297 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2234 tolnaftate 200 µM 0.628830123571189 0.237857084714993 no 830 0.264730138252976 298 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1492 4158-0558 28.5 µM 0.62699914491064 0.238463833776749 no 831 0.265329897835012 264 3967268 SGTC_1061 3448-9325 110 µM 0.625519427959481 0.238954800339776 no 832 0.26581510073972 298 723482 SGTC_865 0488-0499 301 µM 0.625017958693358 0.239121311959524 no 833 0.265979635739569 274 9634651 SGTC_868 0527-0199 213 µM 0.624320212215908 0.239353102406517 no 834 0.26620865624553 283 2849450 SGTC_744 1594-0068 283 µM 0.623245317303091 0.239710421090407 no 835 0.266561662985038 305 668392 SGTC_1773 st048542 73.5835 µM 0.622327652657355 0.240015703166655 no 836 0.266863220860634 302 3237138 SGTC_2851 9015922 71.43 µM 0.618082269950629 0.241430781565086 no 837 0.268260554501005 306 2996893 SGTC_3050 9093513 49.47 µM 0.617119001412781 0.24175248956015 no 838 0.268578118191662 304 25236664 SGTC_904 1141-0088 396 µM 0.616353313959319 0.242008376210424 no 839 0.268830679435671 304 1378119 SGTC_1243 0416-0003 5.65 µM 0.614725941405719 0.242552718702243 no 840 0.269367862503351 313 2141977 SGTC_946 3434-1334 87.4 µM 0.613253917505217 0.243045668961583 no 841 0.269854229331549 291 4047976 SGTC_218 alverine citrate 93.75 µM 0.609557802419527 0.244285805916183 no 842 0.271077385863618 306 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1360 1598-0022 39.8 µM 0.608624181333455 0.244599597349568 no 843 0.271386786251638 318 761525 SGTC_6 0844-0013 19.835 µM 0.607893200234302 0.244845432623772 no 844 0.271629154859085 316 1584900 SGTC_5 0352-0601 109.883 µM 0.604980241568311 0.245826405310449 no 845 0.272596062579723 299 762456 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.604854866645526 0.245868674076258 no 846 0.272637716999211 314 279621 SGTC_948 3448-0295 75.3 µM 0.604510260343287 0.245984874365317 no 847 0.27275222487157 299 678569 SGTC_2488 5268135 45.7 µM 0.604371316943858 0.246031734028097 no 848 0.272798400576139 313 1270356 YLR208W SEC13 SGTC_1579 chlormadinone acetate 49.4 µM 0.602962369584388 0.246507182063778 no 849 0.273266861521129 330 45114258 A steroidal progestin. SGTC_1446 4239-0190 62 µM 0.602602622419221 0.246628657269469 no 850 0.27338653769695 318 1340085 SGTC_335 4077-0256 27.6 µM 0.60221408364281 0.246759890493947 no 851 0.273515821049421 313 3121989 SGTC_233 rapamycin 362 pM 0.600956844400854 0.247184792908681 no 852 0.273934365210945 288 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3234 9132280 49.47 µM 0.600918699636223 0.247197690603482 no 853 0.273947068829532 295 17612295 SGTC_1480 1070-0044 41.2 µM 0.600892779135185 0.247206455175717 no 854 0.27395570148202 297 3124987 SGTC_1853 st056710 91.2 µM 0.600430386908518 0.247362833084628 no 855 0.274109720763473 314 269167 SGTC_1989 st071868 50.2 µM 0.598463358388024 0.248028659249213 no 856 0.274765400461642 308 16414057 SGTC_936 3005-4620 401 µM 0.597874422007637 0.248228196170334 no 857 0.274961863951502 338 777207 SGTC_1650 st011916 45.8 µM 0.597747779574741 0.248271114940911 no 858 0.275004119684496 322 242528 SGTC_3126 9127922 49.47 µM 0.59688471507194 0.248563710447485 no 859 0.27529217643987 341 45595682 SGTC_1516 st013856 110 µM 0.596591174857767 0.248663268090334 no 860 0.275390182373375 302 5281404 A mutagen and neurotoxin. SGTC_2323 6148992 148.28 µM 0.596453313987521 0.248710032566955 no 861 0.27543621668679 303 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_399 oxolinic acid 75 µM 0.59598028295892 0.248870527391195 no 862 0.275594199335912 304 4628 A DNA gyrase inhibitor. SGTC_813 k007-0158 173 µM 0.595299684264982 0.249101544593289 no 863 0.275821583468736 311 6523916 SGTC_1818 st052136 56.3 µM 0.594704106654032 0.249303796442851 no 864 0.276020638144347 294 674169 SGTC_112 phenothiazine 287.218 µM 0.593876635801188 0.249584941630603 no 865 0.276297313497663 324 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3328 9140624 29.0385 µM 0.593429254802011 0.249737015915283 no 866 0.276446957645877 305 4904392 SGTC_1460 k062-0059 9.15 µM 0.592368467456769 0.250097796580227 no 867 0.276801938407906 295 1373085 SGTC_1461 k072-0203 53.8 µM 0.591460881082744 0.250406691937164 no 868 0.277105829289027 299 5418714 SGTC_687 k029-0044 34.9 µM 0.591285738516419 0.250466324656225 no 869 0.277164491782929 305 5829338 SGTC_1441 4106-0040 13 µM 0.590901670329178 0.250597118925018 no 870 0.277293153381009 304 2904180 SGTC_1247 0448-0043 5.84 µM 0.590825921750996 0.250622919344393 no 871 0.277318532357351 321 3089013 YGL099W LSG1 SGTC_2067 5224629 34.075 µM 0.588716626053307 0.251341922841054 no 872 0.278025691436405 304 2835000 SGTC_1735 st034310 56.75 µM 0.585574840203501 0.252414893505598 no 873 0.279080629989327 294 871153 SGTC_956 1185-0240 191 µM 0.584846391632415 0.252664014782083 no 874 0.279325503733371 299 1416193 SGTC_1416 3966-0321 25.3 µM 0.584106189081801 0.252917288372156 no 875 0.279574435555076 303 582530 YLR208W SEC13 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.584016175972487 0.252948097083287 no 876 0.279604714514198 286 6708561 SGTC_706 4262-0057 46.9 µM 0.58399881974726 0.252954037810996 no 877 0.279610553051671 322 883298 SGTC_2657 nystatin 74.44 µM 0.583731733919189 0.253045465805178 no 878 0.279700406697953 301 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2630 antimycin a 100 µM 0.583096676152469 0.253262926610685 no 879 0.279914110585626 315 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.583045759330025 0.253280366149686 no 880 0.279931248081653 314 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2592 piperlongumine 83.33 µM 0.581194836497533 0.253914754787654 no 881 0.280554573656213 317 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1988 st071872 53.4 µM 0.581043640856593 0.253966612671823 no 882 0.280605520678541 295 16414116 SGTC_2145 5634607 200 µM 0.581005102090078 0.253979831791481 no 883 0.280618507452656 319 308662 SGTC_842 0271-0008 11.1 µM 0.580313364460253 0.254217164976509 no 884 0.280851658290552 295 1221709 SGTC_1269 0831-0796 3.05 µM 0.578945906266232 0.254686677892523 no 885 0.28131283676791 315 927758 SGTC_1336 1486-0901 104 µM 0.578533530011148 0.254828355181517 no 886 0.281451983333247 299 5006114 SGTC_2619 obliquin 87.91 µM 0.578424649455386 0.254865769412304 no 887 0.281488728029681 314 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1892 st058411 7.36 µM 0.578336425617273 0.254896087558604 no 888 0.281518503253832 311 3934738 SGTC_2730 imipramine 71.33 µM 0.578162352546875 0.254955913352982 no 889 0.281577256737271 294 3696 A tricyclic antidepressant. SGTC_3098 9119039 49.47 µM 0.577083792176065 0.255326758955681 no 890 0.281941426328295 314 17161528 SGTC_2131 toluylene red 5.2905 µM 0.575865795598303 0.255745886189847 no 891 0.282352948323541 277 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1158 4092-0494 91.8 µM 0.57390158705739 0.256422549850193 no 892 0.283017199526005 311 1148199 SGTC_2786 7743617 45.45 µM 0.572618348349544 0.256865124835477 no 893 0.283451566755486 304 583674 SGTC_311 1315-0136 58 µM 0.571954660940167 0.257094179224714 no 894 0.283676345554329 316 6759207 SGTC_1524 corynanthine 62.1 µM 0.571759121138373 0.257161684937339 no 895 0.283742587591384 334 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3207 9114163 49.47 µM 0.569001141387475 0.258114796135178 no 896 0.284677682679161 358 849233 SGTC_2865 9030313 51.95 µM 0.56809101901422 0.258429720525997 no 897 0.284986582860619 307 42562754 SGTC_708 3448-5400 146 µM 0.567454505731389 0.258650087771034 no 898 0.285202713662104 324 3462195 SGTC_1754 st042065 16.137 µM 0.566758066768906 0.258891313290805 no 899 0.28543928193294 316 1126236 YIL048W NEO1 SGTC_264 promethazine 12.5 mM 0.56293565874206 0.26021734999173 no 900 0.286739348749629 331 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3314 9135860 59.4275 µM 0.562341240422323 0.260423874485097 no 901 0.286941772597868 317 25252478 SGTC_32 0928-0142 34.1 µM 0.5616658246482 0.260658643123545 no 902 0.287171861538232 323 2244242 SGTC_2753 fluvastatin 17.09 µM 0.559384681047322 0.261452353200217 no 903 0.287949606932655 339 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_198 3454-2873 16.191 µM 0.559246490735704 0.261500475517484 no 904 0.287996754212163 314 710957 SGTC_1300 1094-0077 113 µM 0.557595649913521 0.262075702899462 no 905 0.288560263811794 326 5532636 SGTC_3290 9121031 71.43 µM 0.557539040142662 0.262095439791022 no 906 0.28857959659748 312 17014854 SGTC_2172 5754775 163.918 µM 0.556699561772372 0.262388211749453 no 907 0.288866358195027 305 2263357 SGTC_39 0986-0283 58.349 µM 0.556074629556219 0.262606268430265 no 908 0.289079918947083 284 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_56 0957-0365 83.25 µM 0.555751769672521 0.262718959774985 no 909 0.289190280316019 297 6752360 SGTC_2686 alizarin 95.37 µM 0.553591853951172 0.26347349479094 no 910 0.289929101118336 288 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1412 3909-8563 178 µM 0.552062883544147 0.264008286105111 no 911 0.290452635236104 344 23767530 SGTC_3010 9080089 71.4286 µM 0.550966257660431 0.264392195704234 no 912 0.290828402749769 312 17027233 SGTC_161 4065-0411 162.148 µM 0.550113691608154 0.264690860428529 no 913 0.291120698169046 326 1906281 YLR208W SEC13 SGTC_447 ml7 120 µM 0.549316513082246 0.26497027733576 no 914 0.291394128471165 335 4216 Selective myosin light chain kinase inhibitor. SGTC_491 tetrandrine 80.3 µM 0.545479798580043 0.266317167135526 no 915 0.292711785351643 340 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1705 st027868 56.3335 µM 0.544896290778894 0.266522312378765 no 916 0.292912423750255 334 292948 SGTC_409 arachidonic acid 100 µM 0.544064552767267 0.266814866604896 no 917 0.293198526062803 317 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1350 1495-0454 146 µM 0.544045607311091 0.266821532339716 no 918 0.293205044454184 334 1069057 SGTC_1268 0828-0275 2.46 µM 0.543007853985082 0.267186782075044 no 919 0.29356219742285 335 745337 SGTC_2532 xanthone 78.9 µM 0.540824871524429 0.26795593184492 no 920 0.294314149035079 308 7020 An insecticide. SGTC_3079 9117512 49.47 µM 0.54048219072816 0.268076772811899 no 921 0.29443226982375 372 7185044 SGTC_435 c-PAF 6.7 µM 0.539804881528428 0.268315695861226 no 922 0.29466580012127 319 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1125 tnp00248 1.32998 µM 0.539609107804561 0.268384775635628 no 923 0.29473331710438 341 24207736 SGTC_3109 9122853 49.47 µM 0.536480385069833 0.269489973909944 no 924 0.295813294328042 368 1234709 SGTC_1567 st069303 68.4 µM 0.536254987251521 0.269569682026087 no 925 0.295891167635305 342 5581319 SGTC_2777 climbazole 1.536 µM 0.535580536071869 0.269808260786462 no 926 0.296124241827106 314 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1835 st008666 49.2 µM 0.535282239330745 0.26991381327843 no 927 0.296227352906239 316 690455 SGTC_3322 9139058 2.11 µM 0.534799568007455 0.270084650603158 no 928 0.296394230906402 297 4908926 YPR165W RHO1 SGTC_3063 1327-0034 4 µM 0.533903193156905 0.27040205814604 no 929 0.296704256368339 331 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_232 clozapine 119 µM 0.533289490945429 0.270619478390031 no 930 0.296916600610247 326 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1647 st011722 22.4 µM 0.532496487542598 0.270900550070572 no 931 0.297191086948942 320 2854783 SGTC_2540 epiandrosterone 100 µM 0.5302723754125 0.27168963956596 no 932 0.297961548447575 343 441302 A steroid. SGTC_2627 acetyl isogambogic acid 100 µM 0.530267810859235 0.271691260192917 no 933 0.297963130604296 333 6857789 A caspase activator and apoptosis inducer. SGTC_2807 7945238 51.95 µM 0.529912269156768 0.271817508681 no 934 0.298086379553435 348 17148797 SGTC_784 4579-0127 173 µM 0.528870030075349 0.272187763096028 no 935 0.298447806732514 332 1948547 SGTC_2233 sulbentine 40.3845 µM 0.528299985346831 0.272390376919607 no 936 0.298645570896674 311 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1860 st056228 74.6 µM 0.525553951478247 0.273367461786865 no 937 0.299599079211056 366 688679 SGTC_2469 5655019 90.81 µM 0.52371371376887 0.274023219051778 no 938 0.300238837906891 339 2788239 SGTC_1824 st053723 68.6 µM 0.523306571550661 0.274168406597696 no 939 0.300380464303688 339 675225 SGTC_1462 k081-0014 26.5 µM 0.523018783020779 0.274271055349957 no 940 0.300480591146469 312 3270634 SGTC_3146 9095609 49.47 µM 0.522769952060213 0.274359823965436 no 941 0.300567176095159 330 17173999 SGTC_1015 4130-4525 82 µM 0.522317314745991 0.274521335354698 no 942 0.300724707795519 325 1363237 SGTC_136 0097-0015 404.482 µM 0.522056317102583 0.274614486627154 no 943 0.300815559931674 319 4861337 SGTC_3203 9113543 49.47 µM 0.520756883683944 0.275078492366206 no 944 0.301268071175349 332 17018012 SGTC_3278 9139605 49.47 µM 0.519457058987385 0.275543023816739 no 945 0.301721025127838 337 7958859 SGTC_1367 1812-0510 76.9 µM 0.519063112769843 0.275683888490574 no 946 0.301858365229026 313 1142582 YDR527W RBA50 SGTC_1929 genistein trimethyl ether 50.5 µM 0.518424484325772 0.275912320194727 no 947 0.302081067709122 319 136420 SGTC_2204 7233102 200 µM 0.516343678357694 0.276657250326689 no 948 0.302807197499276 344 2172480 SGTC_1398 3558-0053 112 µM 0.515541110287472 0.276944833470142 no 949 0.303087474904059 333 4532369 SGTC_2663 amphotericin b 100 µM 0.513789352799819 0.277573046312301 no 950 0.303699636359714 331 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_89 0302-0250 142.109 µM 0.513030418210472 0.277845430396336 no 951 0.303965021515138 339 4203518 YLR208W SEC13 SGTC_654 1124-0271 80.9 µM 0.511828965176166 0.27827690240652 no 952 0.304385358314503 337 5403748 SGTC_109 0132-0036 33.701 µM 0.51058586036279 0.278723676179354 no 953 0.304820539438165 310 67274 A color developer. SGTC_1838 st055369 84.5 µM 0.509532172491539 0.279102646441039 no 954 0.305189626619665 305 676036 SGTC_2543 pimpinellin 60.67 µM 0.508625777844087 0.279428841419773 no 955 0.305507278333918 342 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1880 MG-132 525 µM 0.507945359597874 0.279673833206283 no 956 0.305745831456056 341 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2278 7948257 134.34 µM 0.507618038764797 0.279791725659072 no 957 0.305860618792407 331 1247028 SGTC_751 0833-0568 350 µM 0.506277428948629 0.280274829881044 no 958 0.30633095288846 353 6954252 SGTC_1070 indatraline 8.81 µM 0.506101802766632 0.280338148723014 no 959 0.306392592534776 365 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1531 st059297 52.4 µM 0.505853932004473 0.280427525827225 no 960 0.306479597235957 336 7566702 SGTC_285 1486-1325 46 µM 0.505316099975547 0.280621504434422 no 961 0.306668418268965 337 22310230 SGTC_3046 9092212 49.47 µM 0.504434611645681 0.280939569070674 no 962 0.30697800046788 362 25236637 SGTC_2246 7293507 91.5585 µM 0.503569494515286 0.281251895854558 no 963 0.307281966912995 335 887656 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.503355045868465 0.281329342570741 no 964 0.307357335806549 340 551469 SGTC_3303 9125618 40.5795 µM 0.503260087688922 0.281363639379782 no 965 0.307390711863744 344 22695467 SGTC_3238 9133470 49.47 µM 0.502191303920969 0.281749799718996 no 966 0.307766479695564 329 3534688 SGTC_673 1082-0474 110 µM 0.501496329931313 0.28200103651383 no 967 0.308010930055965 335 3098046 SGTC_309 k408-0051 1.48 µM 0.501387619546731 0.28204034565321 no 968 0.308049175588742 355 3640463 SGTC_1067 clotrimazole 1.36 µM 0.50076447252753 0.282265723444913 no 969 0.308268445913785 316 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2449 5812982 45.77 µM 0.4995452773143 0.28270692850613 no 970 0.308697649012153 341 776185 SGTC_19 0279-0214 38.434 µM 0.499111881755713 0.282863846447741 no 971 0.308850283758262 333 3566274 YBR002C RER2 SGTC_1697 st025554 27.742 µM 0.498274043150761 0.28316731814462 no 972 0.309145450255879 331 1269519 SGTC_522 1273-0010 11.6 µM 0.495446553269596 0.284192608594866 no 973 0.310142470193337 333 5705015 SGTC_2674 ligustilide 100 µM 0.494505368640858 0.284534289671693 no 974 0.310474657890854 339 5319022 A signalling regulator. SGTC_1857 st056007 79.3 µM 0.494396654388826 0.284573769169129 no 975 0.310513038158495 322 619834 SGTC_2447 5741742 33.78 µM 0.493955400996564 0.284734036851206 no 976 0.310668838571384 329 1776504 SGTC_2973 9094665 17.96 µM 0.493947946087118 0.284736744919522 no 977 0.31067147108764 359 25237061 YIL048W NEO1 SGTC_2837 9008476 45.46 µM 0.493313716155969 0.284967180104264 no 978 0.310895469129813 349 2992805 SGTC_1482 3346-2049 8.48 µM 0.491608775437585 0.285587077869019 no 979 0.311497969304669 319 3826804 SGTC_1408 3909-7976 48.8 µM 0.487443931625242 0.287104062226771 no 980 0.312971883627894 340 24152374 SGTC_878 0828-0289 13.7 µM 0.486302918297695 0.287520324728182 no 981 0.313376205223417 345 745350 YLR208W SEC13 SGTC_41 0478-0632 82.643 µM 0.485514900140839 0.287807974636319 no 982 0.313655572925936 378 3750424 SGTC_188 3229-0966 278.469 µM 0.48537884081297 0.287857654068922 no 983 0.3137038194198 354 5722370 SGTC_2277 7947813 106.88 µM 0.484786451538358 0.28807400074695 no 984 0.31391391715876 366 1246798 SGTC_604 1000-0114 314 µM 0.483011415400561 0.288722721300925 no 985 0.314543815433935 350 1572745 SGTC_2737 bleomycin 30.5 nM 0.482594719974427 0.288875110171768 no 986 0.314691764434282 335 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1466 k213-0079 57.5 µM 0.482318781775688 0.288976043820884 no 987 0.314789753522638 353 3657981 SGTC_1797 st048695 56.8 µM 0.479968858902496 0.289836278486943 no 988 0.315624768272105 367 592262 YIL048W NEO1 SGTC_2390 9097792 176.6 µM 0.47953096762657 0.289996709728998 no 989 0.315780471548574 333 4497149 SGTC_2659 sanguinarine 24.21 µM 0.47916196977309 0.290131932643126 no 990 0.315911703420174 347 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2846 9008642 19.48 µM 0.478904519622751 0.290226295293782 no 991 0.316003277764654 368 2992898 SGTC_2247 cerulenin 830 nM 0.478865379306276 0.290240642568873 no 992 0.316017200861671 323 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1946 st076057 65.1 µM 0.475629949055926 0.291427769105721 no 993 0.317169017499623 354 953009 SGTC_3215 9129942 49.47 µM 0.474115135017351 0.291984353922208 no 994 0.317708903167371 363 17682944 SGTC_1721 st082152 9.2685 µM 0.472710392275897 0.292500937358349 no 995 0.3182099056435 347 5296051 SGTC_1276 0871-0068 94.2 µM 0.471862702228887 0.292812874277663 no 996 0.318512395943412 352 3414906 SGTC_1144 3486-0183 12.5 µM 0.466425068079683 0.294817503146983 no 997 0.320455635744427 378 6744069 SGTC_926 2268-1401 59.4 µM 0.465659408810832 0.295100277161263 no 998 0.32072965572231 343 2931578 SGTC_2470 5664817 21.68 µM 0.465324672935928 0.295223941363464 no 999 0.320849484255493 350 2859561 SGTC_2180 6301957 200 µM 0.464342837980913 0.295586806185217 no 1000 0.321201068533478 353 845462 SGTC_2951 9072950 58.06 µM 0.46394376200601 0.295734354562348 no 1001 0.321344019084324 354 16488155 SGTC_1242 0402-0103 60.1 µM 0.463785070256997 0.29579303627709 no 1002 0.32140087043638 340 432868 SGTC_3132 9126706 49.47 µM 0.462685559012981 0.296199765102062 no 1003 0.321794885438607 371 850858 SGTC_2346 9031566 143.75 µM 0.462185671918732 0.296384767053608 no 1004 0.321974088640987 365 4771086 SGTC_2936 9038235 15.59 µM 0.461373442810636 0.296685475774742 no 1005 0.32226535079035 331 4749415 SGTC_1286 0929-0070 131 µM 0.460427518469773 0.297035858005594 no 1006 0.322604693112868 343 1420408 SGTC_1995 st072814 61.1 µM 0.460101390615777 0.29715670370772 no 1007 0.322721722991357 342 5769371 SGTC_1339 1486-1321 22.7 µM 0.458719078265197 0.297669164768376 no 1008 0.323217955961571 358 3469382 SGTC_1210 3013-0140 750 nM 0.454257349407676 0.29932599477736 no 1009 0.324821805005305 365 905973 SGTC_1901 st060216 58.6 µM 0.453319711475917 0.299674710882175 no 1010 0.325159270509994 346 688792 SGTC_866 0495-0101 262 µM 0.451305124673326 0.30042457587628 no 1011 0.325884825933631 358 635694 SGTC_277 nystatin 15.5 µM 0.451256947633146 0.30044251860039 no 1012 0.325902185031515 377 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2990 9074105 71.4286 µM 0.450028516846272 0.300900190317441 no 1013 0.326344939261922 375 6502001 SGTC_518 1021-0119 62.6 µM 0.449676293997049 0.301031474601215 no 1014 0.326471933528325 357 1097762 SGTC_304 1310-0298 97 µM 0.448762498443273 0.301372194617787 no 1015 0.326801497100142 379 1550234 SGTC_186 3455-3465 67.277 µM 0.447149738243798 0.30197395546541 no 1016 0.327383474396836 368 755278 SGTC_3193 9111931 49.47 µM 0.444072162400009 0.303123770312613 no 1017 0.328495206013053 366 17087244 SGTC_450 aminopyrene 156 nM 0.444042149337541 0.303134993146078 no 1018 0.328506055315534 378 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1455 4262-0120 131 µM 0.443872288701186 0.303198512913124 no 1019 0.328567460285403 346 1529587 SGTC_1190 1486-1332 13 µM 0.443354515016871 0.30339217225767 no 1020 0.328754665098853 364 4150046 SGTC_2337 9009472 200 µM 0.441525687380801 0.3040766380571 no 1021 0.329416234661948 379 5742383 SGTC_1221 2958-7315 257 µM 0.439723013186373 0.304751988239231 no 1022 0.330068866359134 351 4562705 SGTC_1808 st050063 61.5 µM 0.439560132754577 0.304813042265718 no 1023 0.330127860344393 394 4011993 SGTC_467 ro 31-8220 72.8 µM 0.43912846981181 0.304974872893653 no 1024 0.330284225624869 369 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_777 1315-0167 517 µM 0.438130937014895 0.305348994292167 no 1025 0.330645684564665 351 4221767 SGTC_2838 9002687 71.43 µM 0.437734871848887 0.305497593668873 no 1026 0.330789243780713 374 6457060 SGTC_1058 3448-5425 97.3 µM 0.436676039267084 0.305895013543021 no 1027 0.331173154247538 363 7279705 SGTC_2755 lomerizine 42.69 µM 0.435235772475942 0.306435967099118 no 1028 0.331695649693476 352 3949 A calcium channel blocker. SGTC_2027 5150920 200 µM 0.434385585838108 0.306755489124189 no 1029 0.332004231560177 380 786715 SGTC_2979 9012552 45.46 µM 0.43393287132125 0.306925690845777 no 1030 0.332168594341037 385 17100905 SGTC_572 0960-0087 17.7 µM 0.433692661101946 0.307016016744465 no 1031 0.33225581830947 371 6796365 SGTC_1266 0828-0227 32.9 µM 0.432749764281569 0.307370686056615 no 1032 0.332598286228905 349 3913820 SGTC_1305 1181-0477 144 µM 0.431502043023407 0.307840291642511 no 1033 0.333051683712911 355 6252086 SGTC_935 2996-0153 430 µM 0.431165556461408 0.307966989236704 no 1034 0.333173998170914 367 23738523 SGTC_2652 actinonin 100 µM 0.431070955798567 0.308002613434698 no 1035 0.333208389156183 354 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2960 9079389 5.97 µM 0.429426174354676 0.308622285153757 no 1036 0.333806554526422 351 16457355 SGTC_1674 st016616 23.6 µM 0.429058253984513 0.308760973931908 no 1037 0.333940415741158 353 625830 SGTC_87 0100-0052 35.5 µM 0.428903303564111 0.308819391160403 no 1038 0.333996797992084 368 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1909 st060837 51.5 µM 0.428704980850038 0.308894167058657 no 1039 0.33406896771027 384 678937 SGTC_168 3970-0862 530.542 µM 0.428215914819677 0.309078599108606 no 1040 0.334246965261445 384 3135186 SGTC_316 k060-0003 58.6 µM 0.427780190492481 0.309242955977369 no 1041 0.33440558028965 376 6152314 SGTC_390 dec-rvkr-cmk 16.7 µM 0.427648953261753 0.309292466641517 no 1042 0.334453359862205 354 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1006 4099-6547 255 µM 0.427042833248498 0.309521176888087 no 1043 0.334674064914729 364 3146833 SGTC_1130 3454-2858 15.9 µM 0.425823291182048 0.309981576231937 no 1044 0.335118306955031 412 715628 YIL048W NEO1 SGTC_1397 3532-0190 20.1 µM 0.425521795513626 0.310095442327193 no 1045 0.335228168243477 338 5322280 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.424020843608595 0.31066257882049 no 1046 0.33577530612654 359 521171 SGTC_37 0566-0070 1.56 µM 0.42379082809963 0.310749530277172 no 1047 0.335859183854853 395 1626686 SGTC_1565 sinapyl alcohol 95.1 µM 0.423006135284812 0.311046242766895 no 1048 0.336145392373425 384 5280507 A phenol propionate derived from cinnamic acid. SGTC_343 4130-2827 29.8 µM 0.42254082822569 0.3112222453479 no 1049 0.336315153155331 345 1118244 SGTC_1671 st016596 74.5 µM 0.421423444745464 0.311645072343114 no 1050 0.336722951180335 367 2829167 SGTC_1949 st076024 69.1 µM 0.42139142393488 0.311657192942972 no 1051 0.336734640263882 356 2921930 SGTC_686 1319-0111 510 µM 0.421282977364122 0.311698243934559 no 1052 0.336774229472218 395 4562600 SGTC_1437 4092-1038 11.6 µM 0.421110057579812 0.311763705234849 no 1053 0.336837358836671 368 3977136 SGTC_3053 9095903 49.47 µM 0.420454226806089 0.312012033561224 no 1054 0.33707683058174 411 17174018 SGTC_1578 josamycin 24.2 µM 0.419075300934779 0.312534438297132 no 1055 0.337580550448683 348 5282165 A P450 substrate. SGTC_54 0159-0055 9 µM 0.417780190914148 0.31302543278373 no 1056 0.338053917667495 383 3319099 SGTC_1265 0819-1001 68.8 µM 0.416922735360026 0.313350688893572 no 1057 0.338367461656293 408 3106768 SGTC_2956 9076196 2.52 µM 0.41375047649012 0.31455527353691 no 1058 0.339528428081104 380 16423868 SGTC_1623 st003709 20.3 µM 0.413293728324867 0.31472887512761 no 1059 0.339695712149096 346 16192618 SGTC_2809 7964133 12.99 µM 0.412813915878995 0.314911287139945 no 1060 0.339871477525776 393 1253665 SGTC_1463 k081-0032 34.1 µM 0.411659721544377 0.315350266237927 no 1061 0.340294425702186 361 977755 SGTC_3220 9131269 49.47 µM 0.411103471805312 0.315561919974618 no 1062 0.34049833217282 374 17722206 SGTC_2529 gangaleoidin 93.61 µM 0.409905699473626 0.316017879268257 no 1063 0.340937562144748 379 4565183 SGTC_2474 5321570 43.32 µM 0.409418928937137 0.316203259610307 no 1064 0.341116125360276 406 2841384 SGTC_201 4262-0159 12.803 µM 0.408355877753841 0.316608269683385 no 1065 0.341506210686472 380 1341029 SGTC_1641 st009299 47.1 µM 0.40833014830292 0.316618075031768 no 1066 0.341515654177695 361 4046054 SGTC_3113 9123498 49.47 µM 0.406936996380587 0.317149189603626 no 1067 0.342027131303115 379 8897275 SGTC_3195 9113082 49.47 µM 0.406574389030794 0.317287489106767 no 1068 0.342160305354974 378 17018038 SGTC_2754 granisetron 64.02 µM 0.404909187178003 0.317922929372229 no 1069 0.342772132499446 397 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.404451604992183 0.318097636572171 no 1070 0.34294032932221 419 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_12 0849-0099 9.267 µM 0.404078895010158 0.318239969052575 no 1071 0.343077352056379 389 6071388 SGTC_249 wiskostatin 11.211 µM 0.402628583411166 0.318794077074855 no 1072 0.34361073945249 375 2775510 A n-wasp and actin depolymerizer. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.401531519570861 0.319213492139255 no 1073 0.344014418406918 382 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2798 7813637 45.45 µM 0.401281923565755 0.319308946755269 no 1074 0.344106285364552 408 956368 SGTC_3120 9124077 49.47 µM 0.400337448058305 0.319670257011896 no 1075 0.344453994734952 405 18774327 YGL155W CDC43 SGTC_52 0329-0193 875 nM 0.40006810520187 0.319773325839616 no 1076 0.344553177619075 401 3739292 SGTC_3083 9117465 49.47 µM 0.39943298156205 0.32001642227421 no 1077 0.344787098020473 386 16420915 SGTC_2582 agaric acid 100 µM 0.398829387591032 0.320247522229646 no 1078 0.345009460833605 355 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1876 myriocin 605 nM 0.397671361102301 0.320691094733049 no 1079 0.345436225305026 399 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_841 0251-0215 91.2 µM 0.395604209301931 0.3214835366513 no 1080 0.346198515675997 392 3888614 SGTC_1085 doxorubicin 7.67 µM 0.395533269341658 0.321510745911229 no 1081 0.346224686836025 395 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.394780468952866 0.321799544006159 no 1082 0.346502455070207 404 688798 SGTC_2462 5162487 171.77 µM 0.393849251456646 0.322156937550536 no 1083 0.346846169854311 403 2259986 SGTC_153 4077-0274 519.67 µM 0.393454272325499 0.322308576966553 no 1084 0.346991995767879 394 3121976 SGTC_2923 7992654 58.14 µM 0.39290222720482 0.322520566321786 no 1085 0.347195848263436 354 2985126 SGTC_3226 9131256 49.47 µM 0.392118177468363 0.322821746326217 no 1086 0.347485448585716 355 17178073 SGTC_3349 9149703 23.001 µM 0.391955969573874 0.322884070380267 no 1087 0.34754537358355 362 4910494 SGTC_2986 9022445 71.43 µM 0.390794003612974 0.323330670145335 no 1088 0.347974753826058 417 6459286 SGTC_187 1488-2104 32.728 µM 0.387142794908116 0.324735661550522 no 1089 0.349325248637574 383 2852859 SGTC_2795 7780010 54.55 µM 0.386139069296415 0.325122335363448 no 1090 0.349696838153676 365 953673 SGTC_2119 5528445 120.635 µM 0.385245856111307 0.325466593986598 no 1091 0.350027635976677 377 791935 SGTC_3031 9088762 49.47 µM 0.381813402222357 0.326790900448477 no 1092 0.351299888519009 381 205253 SGTC_2069 5228469 200 µM 0.381076970612531 0.327075315117495 no 1093 0.351573067613975 394 2835210 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.38065718585026 0.327237483682702 no 1094 0.351728820969854 411 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2003 4023581 200 µM 0.379363646763959 0.327737400427503 no 1095 0.352208921090839 376 16641307 SGTC_2045 5106652 78.05 µM 0.374841333389512 0.329487571358513 no 1096 0.353889236069679 399 673349 SGTC_985 1493-0307 8.71 µM 0.374704898908316 0.329540430911647 no 1097 0.353939974241845 418 3278274 SGTC_2435 5706476 10.6 µM 0.374660633657539 0.329557581570362 no 1098 0.353956436458271 363 5725375 SGTC_2038 4100038 30.985 µM 0.372579503970764 0.330364323477653 no 1099 0.35473071484176 383 3596803 SGTC_2414 st077232 92.9 µM 0.371711075618892 0.330701199942252 no 1100 0.355053988908485 336 729801 SGTC_2052 5265182 7.135 µM 0.371512029063161 0.330778432439294 no 1101 0.35512809906873 412 1239884 SGTC_2358 9037157 4 µM 0.368768103457136 0.331843842070174 no 1102 0.356150290678928 369 2388925 SGTC_2269 7935389 174.42 µM 0.368707532415864 0.33186737594192 no 1103 0.35617286684135 402 97605 SGTC_774 k060-0086 136 µM 0.368475719842004 0.33195744899337 no 1104 0.356259273154785 397 5911235 SGTC_92 0063-0024 660.874 µM 0.368447838125822 0.331968283362363 no 1105 0.356269666342514 412 3594437 SGTC_2641 levomentholum 100 µM 0.368274408976209 0.332035678186446 no 1106 0.356334316184654 392 16666 SGTC_1829 berberine 14.4 µM 0.366294657983113 0.332805396957953 no 1107 0.357072607672032 401 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2727 riluzole 51.77 µM 0.365795165159634 0.332999709177836 no 1108 0.357258963937932 398 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1489 4065-0444 182 µM 0.365477970339866 0.333123127290351 no 1109 0.357377324144387 411 2877968 SGTC_3112 9123419 49.47 µM 0.364747091900155 0.333407575369831 no 1110 0.357650101255824 410 17015854 SGTC_2007 4011539 71.82 µM 0.364528276901055 0.333492753876367 no 1111 0.357731781140705 372 45595301 SGTC_2022 5136654 200 µM 0.364010017293199 0.333694531962871 no 1112 0.357925264544735 409 1713771 SGTC_2748 diazoxide 86.69 µM 0.363844215498628 0.333759095038982 no 1113 0.357987171532367 394 3019 A potassium channel activatior. SGTC_263 alizarin 107.927 µM 0.363498293902159 0.333893812457354 no 1114 0.358116343580381 396 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_862 0452-0056 10.2 µM 0.363428864309251 0.333920854042118 no 1115 0.358142271536343 379 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_135 0933-0004 26.348 µM 0.36332136256754 0.333962725749389 no 1116 0.358182418538809 400 21230617 YGL099W LSG1 SGTC_38 0929-0051 58.268 µM 0.362813369585141 0.334160615927009 no 1117 0.358372151977837 409 1379719 SGTC_305 1682-2595 20.8 µM 0.36202247667117 0.334468802377039 no 1118 0.358667617054709 396 226033 SGTC_1200 1643-0193 18.4 µM 0.361177286312017 0.334798270197592 no 1119 0.358983460316286 406 5403974 SGTC_3002 9075603 71.4286 µM 0.360268191663764 0.335152790866705 no 1120 0.359323291916654 390 20105405 SGTC_1002 4049-0206 172 µM 0.360033666903445 0.335244272601737 no 1121 0.359410978446049 383 4662749 SGTC_2208 7283366 200 µM 0.359632875054655 0.335400633226619 no 1122 0.359560847761156 395 898663 SGTC_992 3909-8734 162 µM 0.359017437656229 0.335640788865277 no 1123 0.359791022188446 398 4288319 SGTC_1262 0737-0114 49.6 µM 0.358609203961034 0.335800126641766 no 1124 0.359943730211773 426 765919 SGTC_2741 miltefosine 3.04 µM 0.357813508077013 0.336110779691797 no 1125 0.36024144049617 411 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2876 9059903 25.97 µM 0.357795415513428 0.336117844635458 no 1126 0.360248210830383 380 6916095 SGTC_2997 9067075 71.4286 µM 0.356885292249972 0.336473312241688 no 1127 0.360588840344274 426 27209819 SGTC_1610 st001799 48.1 µM 0.356272550128301 0.336712713818119 no 1128 0.360818232120413 384 621897 SGTC_1570 verbenone 133 µM 0.355423617748125 0.337044505530872 no 1129 0.36113612899863 419 29025 A natural terpanoid with antifungal properties. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.35523958416461 0.33711644886306 no 1130 0.361205056100557 363 4000243 SGTC_1338 1486-1223 76 µM 0.354910485789167 0.337245116503257 no 1131 0.361328326343477 403 3444526 SGTC_514 4466-0038 2.65 nM 0.354805295477087 0.337286246790897 no 1132 0.361367730472592 374 5722064 SGTC_189 3970-0742 2.116 µM 0.354473397725912 0.337416034320127 no 1133 0.36149206849858 418 2891807 SGTC_1849 st056239 19.2 µM 0.354287200768394 0.337488854502883 no 1134 0.36156182940634 413 5393181 SGTC_3070 9117005 49.47 µM 0.353249075717213 0.337894968640797 no 1135 0.361950859619488 389 8779016 SGTC_2226 7298446 200 µM 0.352840892215274 0.338054701607069 no 1136 0.362103862678282 412 3283010 SGTC_2472 5377652 49.4 µM 0.352581169753354 0.338156353036303 no 1137 0.362201228236402 401 1610903 SGTC_3018 9082602 49.47 µM 0.349720388138024 0.339276798891923 no 1138 0.363274275609305 394 17332089 SGTC_2621 lithochol-11-enic acid 100 µM 0.349400298451914 0.339402253009089 no 1139 0.363394404646123 415 6708711 SGTC_3137 9097352 49.47 µM 0.348672307503267 0.339687643873417 no 1140 0.363667668244718 425 44120435 SGTC_1421 4029-0249 71.4 µM 0.347034176330122 0.340330168700834 no 1141 0.364282821708971 407 2894095 SGTC_1370 2001-0092 44.6 µM 0.346618624099357 0.340493234740777 no 1142 0.364438926184299 417 790957 SGTC_184 1494-0393 24.714 µM 0.345797267916231 0.34081562922281 no 1143 0.36474753926525 379 3090647 SGTC_180 1486-1293 102.781 µM 0.345650386714973 0.34087329453751 no 1144 0.364802737064783 379 4140536 SGTC_3089 9117425 49.47 µM 0.34551575634627 0.340926153461763 no 1145 0.364853333476044 412 9401657 SGTC_224 benfluorex 43.875 µM 0.344458082587488 0.341341528639561 no 1146 0.365250907303683 421 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2969 9091408 28.7 µM 0.34245191651287 0.342129928618447 no 1147 0.36600541192603 381 4286311 SGTC_2858 9025781 8.96 µM 0.342376666977342 0.342159514234255 no 1148 0.366033722841168 395 4894980 YPL153C RAD53 SGTC_1151 3909-8316 15.3 µM 0.341133284128962 0.342648511195137 no 1149 0.366501622667102 410 800431 SGTC_2037 5169046 200 µM 0.338836146455766 0.343552621720605 no 1150 0.367366584693635 374 5718022 SGTC_163 TUB2.036 7.546 µM 0.337845687435121 0.343942724603991 no 1151 0.367739739228134 394 15992207 YJR013W GPI14 SGTC_66 0109-0187 42.4 µM 0.336358450217669 0.34452880090841 no 1152 0.368300288947512 361 759417 SGTC_817 1391-0715 46 µM 0.336285642431009 0.344557501907972 no 1153 0.368327737903013 415 1353946 SGTC_1556 plumbagin 1.48 µM 0.335775260375251 0.344758720822407 no 1154 0.368520173742967 406 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_425 3825-7017 13.1 µM 0.335531757919097 0.344854737522579 no 1155 0.368611996196066 444 3397440 SGTC_546 peri-Naphthalide 147 µM 0.335068738349546 0.345037340701124 no 1156 0.368786617150598 376 223824 A penicillin ester. SGTC_1108 betulinic acid 729.144 nM 0.334964015622501 0.345078645695631 no 1157 0.368826115529971 372 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2729 fluphenazine 10.66 µM 0.334929806647685 0.345092138883266 no 1158 0.368839018464666 402 3372 An atypical antipsychotic. SGTC_2130 NSC 7 2.4545 µM 0.333372786013714 0.345706489232952 no 1159 0.369426451499804 390 21448 SGTC_2216 7189485 200 µM 0.332899279641221 0.345893400334055 no 1160 0.36960515661051 404 731273 SGTC_2949 9072542 2.23 µM 0.332610937798368 0.346007238306648 no 1161 0.369713992942579 387 16457352 SGTC_1212 0520-0165 585 µM 0.332192778998158 0.346172353017837 no 1162 0.369871847995875 422 5403258 SGTC_1746 st038117 42 µM 0.330422063337692 0.346871863841432 no 1163 0.37054053635362 407 2898218 SGTC_1056 3448-1962 115 µM 0.329576039148494 0.347206265252472 no 1164 0.370860164956239 405 715507 SGTC_121 0557-0495 61.343 µM 0.329562714541477 0.34721153291889 no 1165 0.370865199716735 436 3104427 SGTC_2964 9083345 53.42 µM 0.327625236104263 0.34797779719612 no 1166 0.371597519264194 400 17741579 SGTC_2141 5621638 7.665 µM 0.324495675498312 0.349216835863792 no 1167 0.372781397873032 408 2856238 SGTC_2196 6573537 42.6665 µM 0.324035133405684 0.349399307306752 no 1168 0.372955717698688 425 2903087 SGTC_3233 9132340 49.47 µM 0.323196520784459 0.349731663504706 no 1169 0.373273207826316 433 17682950 SGTC_533 1222-0222 6.71 µM 0.322024920585248 0.350196181087591 no 1170 0.373716907694806 423 3982874 SGTC_2546 rhodinyl acetate 100 µM 0.321398731177382 0.350444545471228 no 1171 0.373954122266302 390 6708682 SGTC_14 0354-0009 295 µM 0.321128304599308 0.350551824060604 no 1172 0.374056580677429 431 1713507 SGTC_2442 5158906 48.48 µM 0.316957666270642 0.352207826836788 no 1173 0.375637862349474 417 1893835 SGTC_2880 9042983 58.44 µM 0.315165350733842 0.35292035159863 no 1174 0.376318056019564 410 6464714 SGTC_146 3448-8650 53.125 µM 0.313713646485227 0.353497846756964 no 1175 0.376869267626821 442 2891488 YIL048W NEO1 SGTC_2826 7992541 19.48 µM 0.312216182325029 0.354093898977672 no 1176 0.377438117331768 459 2985066 SGTC_1898 st060199 18.6 µM 0.31188731044612 0.354224851443331 no 1177 0.377563083314938 389 688866 SGTC_1684 st024538 14.6195 µM 0.311717877423938 0.354292324178768 no 1178 0.377627470120934 398 6732859 SGTC_3272 9137413 49.47 µM 0.310531389267382 0.354764943375585 no 1179 0.378078446624252 407 17614870 SGTC_3249 9135183 49.47 µM 0.310261807760129 0.35487235820078 no 1180 0.378180936008334 402 4902779 SGTC_959 1222-0044 107 µM 0.308221145093387 0.355685834481996 no 1181 0.378957031861933 416 6083612 SGTC_1189 1431-2119 7.28 µM 0.307768994427627 0.355866165971835 no 1182 0.379129058000418 418 3107275 SGTC_1388 3346-4487 254 µM 0.307462743122344 0.355988326667481 no 1183 0.379245588580192 421 3345614 SGTC_928 2764-0428 58.7 µM 0.30675616914985 0.356270228612624 no 1184 0.379514486341623 394 662578 SGTC_1292 0kpi-0043 232 µM 0.306284933290006 0.356458281351654 no 1185 0.3796938549166 433 3333905 SGTC_403 arphamenine a 50 µM 0.30612693486048 0.356521340475762 no 1186 0.379754000350165 444 5487158 An arginine aminopeptidase inhibitor. SGTC_451 chloral hydrate 100 µM 0.305867277170227 0.356624981585491 no 1187 0.379852850843211 420 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1222 0366-0074 1.18 µM 0.305789516700256 0.356656021360874 no 1188 0.379882455425795 433 286520 SGTC_718 1130-0073 349 µM 0.304031861042047 0.3573578805556 no 1189 0.380551808894006 417 6740020 SGTC_682 0kpi-0099 17 µM 0.303876028551782 0.357420130223067 no 1190 0.380611170586783 437 1714895 YML126C ERG13 SGTC_1425 4048-4433 7.33 µM 0.301743248706496 0.358272482363811 no 1191 0.38142389815221 449 23734946 SGTC_3074 9116018 49.47 µM 0.300357699621704 0.35882658739133 no 1192 0.381952162856111 418 17027303 SGTC_470 aa-861 153 µM 0.299574778143994 0.359139822729073 no 1193 0.382250762585365 376 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2794 7785382 27.27 µM 0.298959942817386 0.359385875685602 no 1194 0.382485304765949 444 2205081 SGTC_1814 st052110 31.539 µM 0.298667846854133 0.359502790963856 no 1195 0.382596746175871 420 674163 SGTC_3179 9107801 49.47 µM 0.298088896445181 0.359734562396086 no 1196 0.382817657959375 364 4818259 SGTC_1204 4049-0315 18.3 µM 0.297046952724488 0.360151814048621 no 1197 0.383215331452951 383 588402 SGTC_1539 benzyladenosine 56 µM 0.296762406345454 0.360265791082093 no 1198 0.383323954274553 375 92208 A nucleotide analog. SGTC_715 0868-0130 184 µM 0.296287026480507 0.360456235501323 no 1199 0.383505446388711 401 2876258 SGTC_2693 st077581 40.7 µM 0.295877465197958 0.360620339759971 no 1200 0.383661830566271 437 25238761 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.295064511184871 0.360946152670091 no 1201 0.383972299682787 443 7104 SGTC_1626 st003712 1.76 µM 0.294777249306142 0.361061304641889 no 1202 0.384082023512514 427 24207035 SGTC_2738 aclarubicin 5.55 µM 0.293204009935192 0.361692177425746 no 1203 0.38468310961744 416 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2476 5806916 10.51 µM 0.292867806619502 0.36182704460105 no 1204 0.384811598518034 435 2870194 SGTC_3177 9107506 49.47 µM 0.292631285518218 0.361921934773911 no 1205 0.384901998832269 442 8897194 SGTC_2625 euphol 100 µM 0.292197132784865 0.362096135097101 no 1206 0.385067951865688 449 6708538 A triterpene alcohol. SGTC_1769 st044406 64.4 µM 0.292038393453127 0.362159835122795 no 1207 0.385128634556994 452 670903 SGTC_1778 st046819 58.9 µM 0.291193148526563 0.362499085145791 no 1208 0.385451801163512 466 671715 SGTC_1033 k072-0102 21.3 µM 0.291038215435452 0.362561281272628 no 1209 0.385511046119727 429 5965931 SGTC_3139 9095020 49.47 µM 0.290977112514235 0.362585811342617 no 1210 0.385534412036487 430 25236292 SGTC_537 1334-0398 209 µM 0.290615799423201 0.362730873796493 no 1211 0.385672587595452 419 5846986 SGTC_1937 st074714 47.2 µM 0.290493511173044 0.362779975384497 no 1212 0.385719357102254 411 17250970 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.290485630977251 0.362783139544512 no 1213 0.385722370963678 417 688788 SGTC_1964 st076914 61 µM 0.29021166680922 0.362893151069775 no 1214 0.385827155647996 441 24208661 SGTC_456 gingerol 170 µM 0.289614691268548 0.363132908426328 no 1215 0.386055513236199 428 442793 A herb. SGTC_2773 thioridazine 9.09 µM 0.289469119006423 0.363191381306956 no 1216 0.386111204139565 427 5452 An antipsychotic. SGTC_557 1315-0110 16.2 µM 0.288766566122675 0.363473624729866 no 1217 0.386380009503142 418 6833801 SGTC_133 0724-0033 378.92 µM 0.287895313326024 0.363823744565547 no 1218 0.386713437267876 445 280309 SGTC_973 1325-0077 65.9 µM 0.287336425247067 0.364048398063169 no 1219 0.386927367351007 441 2835149 SGTC_3011 9081274 71.4286 µM 0.286767236499081 0.364277240100571 no 1220 0.387145275616885 403 6625322 SGTC_1046 2001-0062 216 µM 0.28619680246443 0.364506631358438 no 1221 0.387363696316092 403 739778 SGTC_1406 3909-7906 11.9 µM 0.286002368415029 0.364584831109625 no 1222 0.387438153779912 433 X1406 SGTC_548 1436-0017 110 µM 0.285119254845425 0.364940082895291 no 1223 0.387776389401738 429 9677137 SGTC_2379 9035213 200 µM 0.284657859127159 0.365125735577459 no 1224 0.387953139485648 447 646551 SGTC_2319 6033012 152.6 µM 0.282364048526124 0.366049169096673 no 1225 0.388832189474528 393 847246 SGTC_2618 avocadyne 43.43 µM 0.280179712034188 0.366929252857348 no 1226 0.38966981551193 431 3015189 SGTC_2110 5483698 200 µM 0.279788823330547 0.367086818484134 no 1227 0.389819763537807 387 2848765 YHR062C RPP1 SGTC_586 0957-0265 8.15 µM 0.278965021569637 0.367418962869573 no 1228 0.390135834144608 458 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2628 lathosterol 100 µM 0.277861966549603 0.367863853266297 no 1229 0.390559160447527 398 6710616 SGTC_2785 7756463 72.73 µM 0.276441711923561 0.368436939490525 no 1230 0.391104411462654 434 2201551 SGTC_31 0508-1974 57.237 µM 0.274329018593032 0.369289972717676 no 1231 0.391915892985595 415 6810525 SGTC_2093 5331342 194.4 µM 0.274296229147414 0.36930321705878 no 1232 0.391928491065862 443 33839 SGTC_11 0438-0307 1.3 µM 0.274091473235304 0.369385925751454 no 1233 0.392007163193121 428 4011476 SGTC_2188 6126565 140.678 µM 0.27373586932348 0.369529582047916 no 1234 0.392143805227218 423 874518 SGTC_389 tpck 16.7 µM 0.273579814624956 0.369592630526339 no 1235 0.39220377398578 391 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3227 9130768 49.47 µM 0.272692838287784 0.369951049054908 no 1236 0.392544670179818 434 17720899 SGTC_2760 etidronate 98.04 µM 0.271348699389916 0.370494417804196 no 1237 0.393061427110285 418 3305 A chelator and antioxidant. SGTC_2058 5236698 133 µM 0.271232905613719 0.37054123959736 no 1238 0.393105953094517 399 766665 SGTC_1499 4480-0877 67.3 µM 0.270458416115793 0.370854457580771 no 1239 0.393403802157336 444 2861909 SGTC_1235 benzylparaben 21.5 µM 0.270372176715929 0.370889339700783 no 1240 0.393436971512037 445 7180 SGTC_1977 st070720 65.3 µM 0.270039537533976 0.371023895563235 no 1241 0.393564918270101 404 682188 SGTC_1133 3473-0247 50 µM 0.266555045489124 0.372434352296009 no 1242 0.394905886024235 404 711311 SGTC_1996 st072960 66.8 µM 0.264543360703549 0.373249425494312 no 1243 0.39568062872264 431 1719405 SGTC_894 0960-0238 55.9 µM 0.26428149329961 0.373355567986735 no 1244 0.395781509841458 444 6741907 YDL195W SEC31 SGTC_2905 7799065 20.05 µM 0.263144846482274 0.373816395366086 no 1245 0.396219469550398 440 1296806 SGTC_3287 9117173 37.0625 µM 0.262938685357446 0.373899998015758 no 1246 0.39629891924128 416 2789709 SGTC_914 3820-6779 408 µM 0.259684992064522 0.375220222008134 no 1247 0.39755338509352 395 2893481 SGTC_2338 7999974 200 µM 0.259177178328429 0.375426405733557 no 1248 0.397749269345154 448 315925 SGTC_3149 9097855 49.47 µM 0.258750918902142 0.375599504064415 no 1249 0.397913714714417 462 25236625 YMR079W SEC14 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.25788177187435 0.375952530768058 no 1250 0.398249076556042 429 676296 Flavone; oxidizing agent. SGTC_1649 st011737 51.3 µM 0.257494317717991 0.376109938847502 no 1251 0.39839860063339 438 1761035 SGTC_1940 st075990 51.1 µM 0.253849493030929 0.377591699959151 no 1252 0.399805917774837 416 1084979 SGTC_2829 7992743 58.44 µM 0.253668881149126 0.377665172693858 no 1253 0.399875688536352 424 16462845 SGTC_564 3555-0129 330 µM 0.253173269793002 0.377866809635274 no 1254 0.400067160692598 445 563260 SGTC_280 3448-3607 3.04 µM 0.252100098395631 0.378303537908892 no 1255 0.40048184695548 438 626179 SGTC_2935 9038016 29.96 µM 0.251747020006092 0.378447257572893 no 1256 0.400618305221039 443 6463195 SGTC_1550 gossypolone 36.6 µM 0.251432714406884 0.378575209019038 no 1257 0.400739788725863 412 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2682 pyrogallin 40.03 µM 0.251302882464923 0.378628066512476 no 1258 0.400789973387808 424 822798 An ATP competetive kinase inhibitor. SGTC_1630 st005209 31.3 µM 0.250180496845435 0.379085109417363 no 1259 0.401223883516781 447 3367314 SGTC_2262 9014885 67.46 µM 0.249752483022963 0.37925944406828 no 1260 0.401389384200684 444 6457424 SGTC_1043 0916-0009 19.3 µM 0.247903552026878 0.380012815372747 no 1261 0.402104515780249 457 3101130 SGTC_1483 3453-0561 55.9 µM 0.247710503768452 0.38009150174331 no 1262 0.402179202142243 445 4546991 SGTC_2050 5263056 171 µM 0.247326526037843 0.380248025619961 no 1263 0.402327765766271 427 763468 YGL055W OLE1 SGTC_839 0122-0028 230 µM 0.246806276899198 0.380460130171647 no 1264 0.402529076240144 456 759448 SGTC_541 4513-1321 94 µM 0.245237965319523 0.381099744977538 no 1265 0.403136090826599 409 747515 SGTC_738 1315-0003 72.4 µM 0.244320542776737 0.381474054207695 no 1266 0.403491287322723 454 6251474 SGTC_8 0354-0001 70 µM 0.243876122071851 0.381655418147848 no 1267 0.403663381369065 437 4993152 SGTC_983 1491-0821 12.2 µM 0.243054554970049 0.381990760400102 no 1268 0.403981567767927 411 46495113 SGTC_472 calcifediol 10 µM 0.241893629644242 0.382464770759102 no 1269 0.404431293193882 428 5283731 A vitamin D metabolite. SGTC_255 tunicamycin 200.472 nM 0.24033405382925 0.383101828854667 no 1270 0.405035648680498 438 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1696 st025591 34.7925 µM 0.238309318553012 0.383929367715604 no 1271 0.405820597183402 411 2787147 SGTC_2195 6536160 144.242 µM 0.238093891756828 0.384017447025512 no 1272 0.405904136102611 426 3834386 SGTC_150 3970-0969 77.2 µM 0.237458880835769 0.384277112166698 no 1273 0.406150407665997 436 6615640 SGTC_2231 micatex 6.853 µM 0.236964884982014 0.384479150138156 no 1274 0.406342016092158 440 20737 An antifungal of unknown mechanism. SGTC_1850 st056238 17 µM 0.235393258936588 0.385122133551337 no 1275 0.406951758845693 467 5393177 SGTC_1828 st055811 49 µM 0.235296223233707 0.385161843158346 no 1276 0.406989413135037 463 5877589 SGTC_3005 9076496 71.4286 µM 0.235175683292248 0.385211173005994 no 1277 0.407036189340894 444 21368410 SGTC_345 1362-0200 395 µM 0.234619993807607 0.385438607756941 no 1278 0.4072518449245 413 1419823 SGTC_2908 7930301 100 µM 0.234502129911946 0.385486852617594 no 1279 0.40729758992708 409 2223178 SGTC_2925 9010536 32.5 µM 0.232796778819239 0.386185096601879 no 1280 0.407959607172756 427 2994177 SGTC_465 cgp-37157 41 µM 0.232793109683217 0.386186599302147 no 1281 0.407961031815308 434 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_182 3448-4371 550.524 µM 0.231088067391998 0.386885086363197 no 1282 0.408623192549605 427 3491403 SGTC_3307 9126885 69.2785 µM 0.22969471043077 0.387456160777547 no 1283 0.40916450274502 421 24824909 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.229392986748887 0.387579855887619 no 1284 0.409281743307309 417 688761 SGTC_2090 5301565 104.445 µM 0.228767029028479 0.387836510871056 no 1285 0.409524997134826 435 2056344 SGTC_2318 6029776 164 µM 0.228444592156937 0.387968735465451 no 1286 0.409650313131944 448 818325 SGTC_1842 st055362 61.2 µM 0.228087340224539 0.388115252154661 no 1287 0.409789170879744 423 676032 SGTC_2160 5660466 132.927 µM 0.227547019319876 0.388336879614632 no 1288 0.409999205915243 458 2859134 SGTC_3041 9091929 49.47 µM 0.227462906741878 0.388371383971576 no 1289 0.41003190471355 427 25236887 SGTC_1836 st055642 81 µM 0.227211396665156 0.388474562778385 no 1290 0.410129683087688 464 8571 SGTC_1307 1187-1599 12.2 µM 0.226701798116116 0.388683643215078 no 1291 0.410327814412009 440 1538471 SGTC_2940 9060638 45.86 µM 0.226297959818877 0.388849354757997 no 1292 0.410484842533367 418 4027022 SGTC_270 tamoxifen 5.46 µM 0.225093159276869 0.389343854277661 no 1293 0.410953401273754 453 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.225045695093122 0.389363339199039 no 1294 0.410971863166266 427 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_615 k087-0205 167 µM 0.222640477514514 0.39035108850043 no 1295 0.411907665265714 460 9642773 SGTC_644 1498-1197 63.3 µM 0.221985889702185 0.390620030559253 no 1296 0.41216243384921 438 6741615 SGTC_1072 oxiconazole 14.9 nM 0.221701723158968 0.390736798704136 no 1297 0.412273044303986 446 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2368 9071271 200 µM 0.221258015606448 0.390919144259368 no 1298 0.412445769258778 449 27209959 SGTC_1022 4477-0945 21.3 µM 0.221175500436786 0.390953057246572 no 1299 0.412477892352134 440 4648966 SGTC_1727 st034309 9.9045 µM 0.220780737740963 0.391115312607813 no 1300 0.412631581279956 465 870305 SGTC_2228 7354201 200 µM 0.220315624609816 0.391306507723554 no 1301 0.412812676211401 458 753451 SGTC_3216 9129716 49.47 µM 0.219362895186487 0.391698230341859 no 1302 0.413183685731563 413 8056934 SGTC_1951 sophoraflavanone G 9.2 µM 0.21907644134088 0.391816029714378 no 1303 0.413295251052558 437 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_814 3342-0569 96 µM 0.217243422669179 0.39257006248763 no 1304 0.414009323118329 454 4346283 SGTC_194 1486-1323 56.904 µM 0.216484476561842 0.392882381738251 no 1305 0.414305062094391 448 5178754 SGTC_1160 4092-0570 10.5 µM 0.216025444321876 0.393071314811832 no 1306 0.414483957051473 458 4994975 SGTC_1612 st002233 45.4 µM 0.215875940415377 0.393132854563025 no 1307 0.414542225842785 465 1035021 SGTC_3183 9108214 49.47 µM 0.213147573917915 0.394256389790352 no 1308 0.41560592925214 473 4974831 SGTC_2453 5731132 22.18 µM 0.213092124930479 0.394279232719265 no 1309 0.415627553491635 450 1362040 SGTC_729 4092-0585 94.1 µM 0.212325108424526 0.39459525237945 no 1310 0.415926704139904 414 2169061 SGTC_1978 st071761 42 µM 0.211683696670548 0.394859574707402 no 1311 0.416176904022719 421 5147680 SGTC_490 phenamil 164 µM 0.21125103916081 0.395037897879164 no 1312 0.41634569289879 447 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2708 st078559 56 µM 0.209907222820206 0.395591902322876 no 1313 0.416870042411046 467 17250902 SGTC_3058 9093861 49.47 µM 0.209396363956734 0.395802565454875 no 1314 0.417069415497245 461 17217477 SGTC_2505 galangin 7.89 µM 0.209328519207567 0.395830544920074 no 1315 0.417095894899175 478 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2523 spermine 47.74 µM 0.209165744890101 0.395897675934445 no 1316 0.417159426280036 455 1103 A DNA binding polyamine. SGTC_326 k292-0812 17.5 µM 0.209149519400262 0.395904367783391 no 1317 0.417165759263597 461 3579357 SGTC_1457 k015-0032 57.3 µM 0.208668461058868 0.396102783721689 no 1318 0.417353531276408 428 4302660 SGTC_2439 5492030 7.2 µM 0.20678439452396 0.39688013909548 no 1319 0.418089122058237 460 5722370 SGTC_609 0986-0026 86.3 µM 0.206036031700726 0.397189023361975 no 1320 0.418381382922609 458 2848610 SGTC_312 4092-0653 6.84 µM 0.205606125675235 0.397366494824362 no 1321 0.418549296082549 442 1148278 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.204596237534369 0.397783474869863 no 1322 0.418943797617369 418 5379071 SGTC_1038 k292-0204 154 µM 0.203984143096996 0.398036263867695 no 1323 0.419182945183031 454 4454212 SGTC_1872 amphotericin b 148 nM 0.20386657501703 0.398084823235369 no 1324 0.419228882888969 472 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_826 1683-5028 118 µM 0.203136171786597 0.398386538410872 no 1325 0.419514300038615 439 722377 SGTC_108 0509-0257 621.132 µM 0.199532648284776 0.399875968919266 no 1326 0.420923053569327 434 536624 SGTC_3028 9087778 49.47 µM 0.199103398751308 0.400053486574405 no 1327 0.421090931319184 473 17217395 SGTC_994 3910-0338 138 µM 0.19900876481484 0.400092625551879 no 1328 0.42112794419891 463 3479481 SGTC_1454 4239-0054 42.6 µM 0.198852506348102 0.400157253577408 no 1329 0.421189060965524 482 1340767 SGTC_536 3852-0578 10.6 µM 0.198819934959763 0.400170725348786 no 1330 0.42120180072525 427 2869208 SGTC_3196 9111891 49.47 µM 0.198685598707661 0.400226289088946 no 1331 0.421254344999632 471 18891510 SGTC_1992 st073643 23.3 µM 0.198398250707273 0.400345147848521 no 1332 0.421366742988164 462 3161292 SGTC_2833 9001315 45.46 µM 0.198176236782852 0.400436988112026 no 1333 0.421453589528055 422 2989378 SGTC_695 3505-6186 243 µM 0.197738757691713 0.400617975728676 no 1334 0.421624732069804 448 1819379 SGTC_1737 st035557 69.7 µM 0.196854179965407 0.400983995778081 no 1335 0.421970825536271 488 5716916 SGTC_422 cantharidin 155 µM 0.196472283393078 0.401142043602078 no 1336 0.422120262262376 468 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1491 4138-0063 26.5 µM 0.196307931248511 0.401210065686927 no 1337 0.422184576966005 466 23883227 SGTC_449 xestospongin c 11.1929 µM 0.195489811202608 0.401548713821355 no 1338 0.42250475664572 472 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_668 1682-0499 62.6 µM 0.19347925361408 0.402381266726729 no 1339 0.42329182614833 455 682214 SGTC_2698 st077697 67.5 µM 0.19345893672644 0.402389682025174 no 1340 0.423299781133241 469 3154499 SGTC_2118 5526350 200 µM 0.193122447346916 0.402529063224001 no 1341 0.423431536563563 453 743594 SGTC_279 1273-0055 2.93 µM 0.191540260614563 0.403184605116502 no 1342 0.424051170493743 471 2847562 SGTC_2916 7875993 68.79 µM 0.19130882636672 0.403280517320567 no 1343 0.424141823182108 467 1299250 SGTC_1060 3448-7350 82 µM 0.190945571198211 0.403431071178589 no 1344 0.424284118156761 433 570178 SGTC_725 1497-0963 19 µM 0.189611163746778 0.403984249159305 no 1345 0.424806919254992 477 3549977 SGTC_303 1348-1668 34.2 µM 0.189209063689488 0.404150977258358 no 1346 0.424964482088417 449 5380509 SGTC_1726 st035556 14.5795 µM 0.189067489094599 0.404209684363211 no 1347 0.425019960922089 410 5919439 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.188197598486781 0.404570451462228 no 1348 0.425360877491786 465 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1775 st081588 35.1725 µM 0.18717648859663 0.404994036791276 no 1349 0.425761129213722 453 1426443 YGL099W LSG1 SGTC_1770 st043884 66.3 µM 0.18692728165188 0.405097431817082 no 1350 0.425858824265937 483 670149 SGTC_2450 5739737 12.93 µM 0.186902546626597 0.405107694647727 no 1351 0.42586852123279 472 2262825 SGTC_47 0149-0135 24.25 µM 0.186119458737917 0.405432640018909 no 1352 0.426175541327598 486 5239155 SGTC_1143 3454-2408 5.08 µM 0.185467231833379 0.405703333884907 no 1353 0.426431289786901 456 X1143 SGTC_129 0088-0017 176.636 µM 0.185464576404304 0.405704436060447 no 1354 0.426432331085844 472 182446 SGTC_2904 7225135 42.03 µM 0.185038939446738 0.405881112701005 no 1355 0.426599246824017 470 4446116 SGTC_78 0336-0123 156.75 µM 0.184644678425467 0.406044782683148 no 1356 0.426753870055604 433 6765896 SGTC_1428 4049-0204 61.7 µM 0.183928041040985 0.4063423231303 no 1357 0.427034953249074 464 X1428 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.18345398403773 0.406539176442721 no 1358 0.427220910690538 460 17037758 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.183366093734111 0.406575675700187 no 1359 0.427255389031629 444 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3338 9144300 39.5675 µM 0.183145871935666 0.406667133404188 no 1360 0.427341781914691 445 4901274 SGTC_3093 9117344 49.47 µM 0.182119109667301 0.407093612993276 no 1361 0.427744626084795 436 24824913 SGTC_860 0443-0016 25.1 µM 0.181988293405966 0.407147957219362 no 1362 0.427795956498918 441 5337942 SGTC_2816 7982706 58.44 µM 0.181205320051376 0.407473260543573 no 1363 0.428103209466677 448 2981853 SGTC_391 gliotoxin 8.33 µM 0.181076808590158 0.407526659530458 no 1364 0.428153643868408 456 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2799 7812892 81.82 µM 0.180893970669961 0.407602635168431 no 1365 0.428225400744798 467 20205235 SGTC_2084 5306078 60.6385 µM 0.180549948314025 0.407745598073393 no 1366 0.428360422766945 474 679340 SGTC_57 miconazole 162.5 nM 0.180483832512007 0.407773074751427 no 1367 0.428386372882779 470 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_308 4092-1169 104 µM 0.179858941453573 0.408032791945741 no 1368 0.428631654722293 465 2268590 YDL196W YDL196W SGTC_307 1501-1223 22.3 µM 0.179360879750694 0.4082398252769 no 1369 0.42882717333245 474 2830329 SGTC_1256 0570-0116 285 µM 0.179097616751822 0.408349268287014 no 1370 0.428930526654626 439 410638 SGTC_800 3448-7362 155 µM 0.176176196229276 0.409564231637918 no 1371 0.43007776046836 455 15991913 SGTC_3221 9128209 49.47 µM 0.17589014906594 0.409683240122382 no 1372 0.4301901223028 469 16460723 SGTC_262 fenpropimorph 62.5 µM 0.174111866633144 0.410423271855635 no 1373 0.430888773709336 478 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2980 9014342 25.29 µM 0.17258395747016 0.411059365773123 no 1374 0.431489231376342 474 2996599 SGTC_2156 5649887 115 µM 0.17210983684044 0.411256797687418 no 1375 0.431675589741352 469 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_192 3455-0609 60.9 µM 0.171087309230932 0.411682672069621 no 1376 0.432077557257156 448 3769639 SGTC_1948 st076329 66.6 µM 0.170963636965815 0.411734187620116 no 1377 0.432126179040788 489 24208413 SGTC_2828 7998861 71.43 µM 0.170328321912225 0.411998851394559 no 1378 0.432375969511315 482 2988188 SGTC_2302 7771753 200 µM 0.169033739916743 0.412538280760685 no 1379 0.432885051311599 467 2203047 SGTC_1100 amiodarone 5.07 µM 0.168990146310655 0.412556448324939 no 1380 0.432902196017609 469 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_282 k297-0036 65.7 µM 0.168987468128708 0.412557564459006 no 1381 0.432903249310185 461 5061378 SGTC_1920 st075728 45.7 µM 0.168928038957612 0.412582331786614 no 1382 0.43292662211846 484 3400306 SGTC_2402 5553605 200 µM 0.168675716773724 0.412687491868125 no 1383 0.433025860138326 451 6758546 SGTC_2889 9059656 51.95 µM 0.165696632485042 0.413929553869116 no 1384 0.434197848155052 453 3949838 SGTC_764 1951-2361 146 µM 0.165330012822407 0.414082467451559 no 1385 0.434342118523878 459 5438930 SGTC_613 3914-0030 117 µM 0.163976940018141 0.414646933858485 no 1386 0.434874648636316 480 1145395 SGTC_2717 st081029 62.2815 µM 0.163765184073037 0.414735288856022 no 1387 0.43495800033688 490 5292846 SGTC_3061 glucosamine 200 µM 0.162875189663995 0.415106685421093 no 1388 0.435308352866019 493 91431 and experimental redox chemotherapeutic SGTC_419 nsc-638432 893 µM 0.161982298569008 0.415479367028618 no 1389 0.435659896733876 429 368090 SGTC_220 paclitaxel 373.376 µM 0.159450393201693 0.416536565238378 no 1390 0.436657019345094 475 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2689 tacrolimus 100 µM 0.158890757431713 0.416770323178909 no 1391 0.43687747134406 485 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_781 4335-2806 94.4 µM 0.157116921158816 0.417511442610138 no 1392 0.437576351025835 489 845254 SGTC_979 1426-2828 121 µM 0.15642416142315 0.41780096151931 no 1393 0.437849346763817 484 747872 SGTC_1749 st037932 54.2 µM 0.155082333735892 0.418361866221364 no 1394 0.438378204658594 467 594497 SGTC_773 4358-1457 44.6 µM 0.153894385438813 0.418858585583977 no 1395 0.438846505569243 481 1186886 SGTC_1378 2093-0007 380 nM 0.153623055604948 0.418972055486786 no 1396 0.438953478494952 495 3618014 SGTC_2490 carminic acid 95.39 µM 0.153110786347241 0.419186304418579 no 1397 0.439155454949842 473 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1064 honokiol 6.76 µM 0.152308869468744 0.419521742221507 no 1398 0.439471664856481 482 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.151023864959533 0.420059375014864 no 1399 0.439978445149487 464 2724278 An inhibitor of dopamine biosynthesis. SGTC_1785 bathophenanthroline 24 µM 0.149816656404976 0.420564594730231 no 1400 0.440454633882581 449 72812 An iron chelator. SGTC_1606 st000094 49.2 µM 0.14932789568776 0.420769179547565 no 1401 0.440647452234327 478 1242210 SGTC_1167 k781-0610 148 µM 0.147053487568611 0.421721478945082 no 1402 0.441544901100912 463 4525169 SGTC_227 fluconazole 33.516 µM 0.14679403572893 0.421830141173286 no 1403 0.441647296242359 479 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2327 6189656 200 µM 0.1462966791821 0.422038458008711 no 1404 0.441843593641689 480 5349088 SGTC_975 1335-0046 28.5 µM 0.145667078155032 0.42230219647008 no 1405 0.442092105962388 478 16486740 SGTC_1682 st012968 530 nM 0.144693652772309 0.42271003072246 no 1406 0.442476375386671 456 24207270 SGTC_167 3672-0051 66.205 µM 0.14383220254539 0.423071020075047 no 1407 0.442816486653606 486 3237971 SGTC_2171 5739187 198.077 µM 0.142475053638286 0.423639862112165 no 1408 0.443352391327154 485 2262761 SGTC_2506 ethyl hematommate 54.16 µM 0.142418136085609 0.423663722299795 no 1409 0.4433748689377 455 3940691 An allergen. SGTC_547 1120-0019 610 nM 0.141316863980128 0.424125437325618 no 1410 0.443809813888687 477 3676939 SGTC_912 3474-0017 2.18 µM 0.141199306398145 0.424174730220535 no 1411 0.443856247000245 485 3360550 SGTC_630 4356-0227 183 µM 0.140607852277986 0.424422749949817 no 1412 0.444089872325583 502 779312 SGTC_716 1683-5115 658 µM 0.139204788061966 0.425011228916562 no 1413 0.444644162509183 500 723597 SGTC_2174 5790901 200 µM 0.138206362932513 0.425430094360712 no 1414 0.445038663232878 487 786020 SGTC_917 harmaline 728.087 nM 0.138022002631579 0.425507447547576 no 1415 0.44511151419226 463 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_477 mead ethanolamide 10 µM 0.136142232509281 0.426296317428754 no 1416 0.445854420800882 472 16061185 SGTC_333 3486-0131 40.1 µM 0.135900490065729 0.426397789250368 no 1417 0.445949974027175 508 6744690 SGTC_690 glyoxal 20.3 µM 0.135449444613693 0.426587129404405 no 1418 0.446128266574429 487 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1087 pterostilbene 9.05 µM 0.133613280190221 0.427358089889357 no 1419 0.446854191141675 482 5281727 Similar to reservatol, lowers cholesterol. SGTC_2314 7727897 200 µM 0.133321809242241 0.427480497001156 no 1420 0.44696944014196 480 900724 SGTC_2605 digitonin 300 nM 0.133049443758675 0.427594886828554 no 1421 0.447077138798732 493 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3302 9125395 16.351 µM 0.132737450295235 0.427725927351699 no 1422 0.447200511931836 474 17599668 SGTC_1294 1000-1494 117 µM 0.132228879865805 0.427939549343699 no 1423 0.447401629423289 472 712797 YDL207W GLE1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.131808381551596 0.428116193121624 no 1424 0.447567928439514 487 688664 SGTC_2088 5278280 127.392 µM 0.131694321106815 0.428164110348 no 1425 0.447613038747653 455 791502 SGTC_3271 9137798 49.47 µM 0.131652690698889 0.428181599704496 no 1426 0.447629503524633 494 6498326 SGTC_1376 2910-0861 41.3 µM 0.130198686469944 0.428792529895037 no 1427 0.448204616890176 474 1112859 SGTC_1497 4476-2978 41.3 µM 0.130119576531153 0.428825774493317 no 1428 0.448235910980811 496 1528379 SGTC_1495 4469-0029 237 µM 0.129413334678035 0.429122582898149 no 1429 0.448515298430452 471 793680 SGTC_3231 9132313 49.47 µM 0.129317057306782 0.429163047970952 no 1430 0.448553387490339 487 4905967 SGTC_791 1348-1292 225 µM 0.128815947654114 0.429373674775083 no 1431 0.448751643132555 498 5437054 SGTC_1231 0242-0792 125 µM 0.128133714796853 0.429660463740176 no 1432 0.449021577700611 486 3707635 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.127122739684483 0.430085513701901 no 1433 0.449421626902625 495 65057 A dermal irritant. YDR527W RBA50 SGTC_2479 5617353 43.85 µM 0.126733359247521 0.430249244755712 no 1434 0.449575720924607 492 2731746 SGTC_588 3970-1144 52.9 µM 0.122662869315925 0.431961562860279 no 1435 0.451187033878276 490 1888707 SGTC_1346 1488-2224 62.4 µM 0.121902490308096 0.432281571458381 no 1436 0.451488121679207 485 3722427 SGTC_905 2-aminofluorene 215 µM 0.121422807137793 0.432483470940482 no 1437 0.451678076523329 500 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2117 5521686 200 µM 0.120909746001487 0.432699438778776 no 1438 0.45188126130811 479 803312 SGTC_334 1502-1024 68.5 µM 0.120811814887345 0.43274066416686 no 1439 0.45192004586375 489 3296216 SGTC_1877 wortmannin 25 µM 0.120141905924288 0.433022690749195 no 1440 0.452185368329614 496 312145 A covalent inhibitor of PI 3-kinase. SGTC_993 3909-8757 62.7 µM 0.118503918219247 0.433712414533318 no 1441 0.452834195341943 481 4288324 YLR208W SEC13 SGTC_178 4092-0806 87.505 µM 0.11814209214773 0.433864799536844 no 1442 0.452977536129601 485 2169044 SGTC_1132 3456-3614 2.5 µM 0.118039429294474 0.433908038342976 no 1443 0.453018208097368 462 3125502 SGTC_1279 0874-0590 65.2 µM 0.117892735759872 0.433969823048758 no 1444 0.453076324566152 478 3523074 SGTC_1034 k072-0165 12.7 µM 0.117635092514022 0.434078341702098 no 1445 0.453178399088148 503 5835461 SGTC_542 3381-0244 89.3 µM 0.117513606604411 0.434129512969904 no 1446 0.453226531119508 506 1112843 SGTC_2981 9013952 38.96 µM 0.116887307684978 0.434393334800956 no 1447 0.453474678101843 475 2996344 SGTC_3015 9080845 49.47 µM 0.115931492109364 0.434796018344526 no 1448 0.453853418436317 501 5296973 SGTC_1353 1498-1206 8.11 µM 0.115757365770338 0.434869384783755 no 1449 0.453922420238427 493 6756808 SGTC_3260 9137109 49.47 µM 0.114787125828889 0.435278226938486 no 1450 0.454306926850749 497 17478346 SGTC_669 0108-0021 26.2 µM 0.114564333487231 0.43537211752246 no 1451 0.454395225634862 485 17201 SGTC_3276 9139060 49.47 µM 0.114421982581759 0.435432109866201 no 1452 0.454451644427112 505 4870619 SGTC_2802 7925815 54.55 µM 0.113823811399515 0.435684219264313 no 1453 0.454688731247592 471 1262923 SGTC_1025 k007-0731 70 µM 0.113344785399528 0.435886131756516 no 1454 0.454878606186012 508 6256118 SGTC_13 0199-0087 65 µM 0.113284249937802 0.435911649027442 no 1455 0.454902601791628 499 4589825 SGTC_45 0kpi-0036 14.9 µM 0.112692586560269 0.436161064553712 no 1456 0.455137139438303 494 2795021 SGTC_140 0062-0056 502.533 µM 0.111228712511387 0.43677826914536 no 1457 0.45571749180261 476 3758964 SGTC_831 k061-1017 217 µM 0.110003037984124 0.437295161539753 no 1458 0.456203482787915 502 1240153 SGTC_1494 4358-1428 177 µM 0.109096211254282 0.437677658145948 no 1459 0.45656308996759 505 1564571 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.10848502345783 0.437935488077549 no 1460 0.456805479973431 504 4620898 SGTC_2429 5902844 64.44 µM 0.108055220737145 0.438116816395506 no 1461 0.456975944388186 510 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_497 capsazepine 133 µM 0.107545422062841 0.438331910835412 no 1462 0.45717814632656 507 2733484 A calcium channel blocker. SGTC_2808 7946468 45.46 µM 0.106877938985302 0.438613563067944 no 1463 0.457442907533584 493 2970879 SGTC_739 1486-1183 203 µM 0.105322541866261 0.439270001332414 no 1464 0.458059938314471 505 4346692 SGTC_2063 5246145 200 µM 0.10527991375049 0.43928799442026 no 1465 0.458076850447967 497 711240 SGTC_246 cycloheximide 667 µM 0.103924152104925 0.43986031902293 no 1466 0.458614770137922 508 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.10378265911495 0.439920056490972 no 1467 0.458670914084992 492 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1486 3970-0793 4.53 µM 0.10338354610986 0.440088566907369 no 1468 0.458829285234876 505 2844330 SGTC_1277 0873-0036 22 µM 0.101868899555822 0.440728167791897 no 1469 0.459430368034298 477 5965735 SGTC_3178 9107506 49.47 µM 0.101323677686234 0.440958440563688 no 1470 0.459646760420747 496 8897194 SGTC_3318 9139014 38.6185 µM 0.100428584054696 0.441336523848223 no 1471 0.460002038841505 511 16643984 SGTC_2484 5809818 12.04 µM 0.100342429098238 0.441372918117521 no 1472 0.460036236950012 491 2870548 SGTC_1234 0326-0494 15.5 µM 0.0999828623500749 0.441524814534742 no 1473 0.460178965562595 509 1547813 SGTC_1017 4239-0030 168 µM 0.0994959805757824 0.441730507983592 no 1474 0.460372239551009 504 1149593 SGTC_2913 7966556 36.57 µM 0.0994213594920313 0.441762034620543 no 1475 0.460401862179471 511 2976516 SGTC_606 k015-0008 38.6 µM 0.0987036139963787 0.442065293489231 no 1476 0.460686799663161 507 1970475 SGTC_1615 st002656 86.5 µM 0.09432589594217 0.443915677621475 no 1477 0.462425139816691 497 1584458 SGTC_2258 7960471 200 µM 0.0935904321060602 0.444226666322242 no 1478 0.462717255162999 511 2974708 SGTC_2342 7990637 118.86 µM 0.0922467715831057 0.444794917738836 no 1479 0.463250989042115 500 2033102 YER133W GLC7 SGTC_281 1672-3440 14.9 µM 0.0918362511160981 0.444968554839073 no 1480 0.463414070762349 513 6833000 SGTC_2399 5884133 200 µM 0.08937719753288 0.446008876215197 no 1481 0.464391072333612 484 722445 SGTC_600 1495-0418 41.6 µM 0.0893457523979105 0.44602218174218 no 1482 0.464403567139268 499 5377768 SGTC_1677 st019204 53.9 µM 0.0884134037088611 0.446416718357656 no 1483 0.464774054198309 478 3945625 SGTC_1260 0700-1617 7.75 µM 0.0881908373436951 0.446510908340417 no 1484 0.464862499841319 516 2853078 SGTC_157 1348-1695 65.819 µM 0.087589591510964 0.446765370371848 no 1485 0.465101437576884 484 5380510 SGTC_1990 st072050 59.8 µM 0.0874751055781252 0.446813826123315 no 1486 0.465146936218385 522 17233948 SGTC_2680 butyl paraben 22.24 µM 0.0874086725466168 0.446841944024531 no 1487 0.465173338035024 515 7184 An antifungal and steroid mimetic. SGTC_2430 5571206 200 µM 0.0870494194609677 0.446994003171806 no 1488 0.46531611505641 518 1731771 SGTC_394 menadione 8.33 µM 0.0867565082407834 0.447117987917776 no 1489 0.465432529307634 519 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2836 9010338 19.48 µM 0.0854049244797435 0.447690158980329 no 1490 0.465969739150237 515 2994051 SGTC_2163 5671233 125 µM 0.0845916042968748 0.448034517430117 no 1491 0.466293036972208 508 701023 SGTC_772 k072-0172 35.3 µM 0.0830416527551914 0.448690872629638 no 1492 0.466909209930017 496 5861980 SGTC_70 0141-0289 43.283 µM 0.0818248435866094 0.449206251136109 no 1493 0.467392999994345 498 352408 SGTC_2178 5812956 200 µM 0.081306860616848 0.449425668448874 no 1494 0.467598959036882 521 5403383 SGTC_2082 5219693 150 µM 0.0811685426592964 0.44948426248173 no 1495 0.467653958133451 506 2834649 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.080755105474 0.449659408645457 no 1496 0.467818356022855 501 6708739 YPR165W RHO1 SGTC_2761 levamisole 97.89 µM 0.0795533290213027 0.450168577912184 no 1497 0.468296257776987 513 26879 An alkaline phosphatase inhibitor. SGTC_1032 k061-1018 98.7 µM 0.0793955783389826 0.450235419911537 no 1498 0.468358992757696 494 4005393 SGTC_471 1-acyl-paf 4 µM 0.0793540941806508 0.450252997782117 no 1499 0.468375490489612 508 16759367 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0788041410600456 0.450486035818959 no 1500 0.468594205101994 497 107982 A Capsaicinoid. SGTC_980 1473-0395 201 µM 0.0779407393841007 0.450851929469545 no 1501 0.468937596308315 527 768876 SGTC_2971 9092186 9.93 µM 0.0766996973390267 0.45137793321001 no 1502 0.469431222660819 511 25236400 SGTC_2198 6589944 200 µM 0.0755884839463647 0.451848982805138 no 1503 0.46987324936554 502 5290268 SGTC_2324 6149169 200 µM 0.0750227918597167 0.452088808940036 no 1504 0.470098288855477 515 2888231 SGTC_3291 9121177 71.43 µM 0.0745195617692624 0.452302168901342 no 1505 0.47029848820018 495 17015612 SGTC_362 0310-0100 9.03 µM 0.0743794262212191 0.452361586155886 no 1506 0.470354239473891 508 790235 SGTC_1733 st037357 54.9 µM 0.0738279926983591 0.45259540345895 no 1507 0.470573626424174 521 1272339 YGL099W LSG1 SGTC_2929 9013348 24.6 µM 0.0716778786481895 0.453507245092689 no 1508 0.471429130576215 510 2995952 SGTC_2150 5556613 200 µM 0.0700815878201608 0.45418437473941 no 1509 0.472064360728234 500 743190 SGTC_637 1181-0519 7.26 µM 0.0694540268958431 0.454450616011177 no 1510 0.472314112730314 520 6252091 YGR060W ERG25 SGTC_411 enrofloxacin 100 µM 0.0685861121909122 0.454818860518866 no 1511 0.472659536849909 518 71188 A bacterial gyrase inhibitor. SGTC_274 sirtinol 40.1 µM 0.0680477616562843 0.455047294925762 no 1512 0.472873807032076 518 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0670631456923567 0.455465128333118 no 1513 0.473265716646492 518 6728940 SGTC_2351 9026858 72.31 µM 0.0667634660838664 0.455592310713239 no 1514 0.473385004164903 510 1409300 SGTC_499 genistein 192 µM 0.0663101029043773 0.455784724203011 no 1515 0.473565469987514 532 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2552 juarezic acid 87.02 µM 0.0655153729785401 0.456122043372628 no 1516 0.473881833382531 500 1549512 SGTC_1181 1222-0449 220 µM 0.065456727797814 0.456146936284297 no 1517 0.473905179312345 513 658318 SGTC_2311 7694451 200 µM 0.065156368450892 0.456274431446219 no 1518 0.474024750101201 525 2163142 SGTC_1037 k284-1091 78.7 µM 0.0646918965693802 0.456471597205452 no 1519 0.474209657454714 512 3334711 SGTC_812 4251-0442 148 µM 0.063190140495453 0.457109157501397 no 1520 0.474807547917499 526 5723007 SGTC_780 0109-0199 192 µM 0.0626027975145605 0.457358540082983 no 1521 0.475041400847455 523 610414 SGTC_1169 aniline yellow 25.8 µM 0.0619124013982873 0.457651699918077 no 1522 0.475316295778873 527 6051 A DNA damaging agent. SGTC_3030 9087619 49.47 µM 0.0610227707899093 0.458029493764454 no 1523 0.475670537189515 527 25236973 SGTC_3009 9080819 71.4286 µM 0.0604215011814262 0.458284852652149 no 1524 0.475909967236942 513 17027216 SGTC_1591 genipin 88.4 µM 0.0599344590485098 0.458491711817813 no 1525 0.476103917431471 524 442424 A DNA cross-linking agent. SGTC_123 0083-0120 66.675 µM 0.0596726792323536 0.45860290100398 no 1526 0.47620816588065 527 16001701 SGTC_1628 st004252 77.7 µM 0.0592564597205943 0.458779694059958 no 1527 0.476373920125001 520 692968 SGTC_717 1532-0246 73.2 µM 0.0589719019924944 0.458900567260234 no 1528 0.476487244056025 504 9561992 SGTC_474 dl-dihydrosphingosine 5 µM 0.0573588630101177 0.459585818472959 no 1529 0.477129665792455 490 3058739 A sphingolipid protein kinase C inhibitor. SGTC_924 2046-0044 21.3 µM 0.0569690806146828 0.459751423919207 no 1530 0.4772849126103 520 3623589 SGTC_1258 0671-0043 57.1 µM 0.05613824957372 0.460104439389472 no 1531 0.477615836607615 514 4298767 SGTC_2620 irigenin 100 µM 0.0544114296825171 0.460838255817672 no 1532 0.478303686388054 531 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2832 7992762 51.95 µM 0.051570146716745 0.462045955233897 no 1533 0.479435603572207 524 2985177 SGTC_3142 9086498 49.47 µM 0.051402533690828 0.462117210906023 no 1534 0.479502382925432 521 25236367 SGTC_563 tetrahydrosecaminediol 614 µM 0.0513184894689418 0.462152940254756 no 1535 0.479535867525269 519 334274 A psychoactive constituent of the cannabis plant. SGTC_3047 9092122 49.47 µM 0.0498448302910896 0.46277947984023 no 1536 0.480123020827387 513 17173831 SGTC_2571 chrysanthemic acid 100 µM 0.0493051268077341 0.46300896286516 no 1537 0.480338066943631 510 2743 An insecticide. SGTC_1553 gossypol 38.6 µM 0.0476837269518212 0.463698459144309 no 1538 0.480984151680293 524 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_114 0364-0001 490.298 µM 0.0475864037635949 0.463739849079355 no 1539 0.481022933989496 506 4003655 SGTC_2054 5233173 129 µM 0.0459107601369526 0.464452533646221 no 1540 0.481690688936391 527 6889 SGTC_1554 st069299 38.7 µM 0.0458805715625606 0.464465374500287 no 1541 0.481702719757492 527 24207999 SGTC_3038 9091290 49.47 µM 0.0452493992920823 0.46473385509101 no 1542 0.481954259802969 535 25236843 SGTC_1369 1866-0067 208 µM 0.0445623934147425 0.465026103766726 no 1543 0.482228059285985 521 3531355 SGTC_1752 st044819 83.042 µM 0.0441689441966693 0.465193483494741 no 1544 0.482384868412603 518 441209 YML126C ERG13 SGTC_3341 9147222 25.867 µM 0.0440963716418552 0.465224357719314 no 1545 0.482413792491797 521 1939759 SGTC_452 diindolylmethane 8 µM 0.0422390940435959 0.466014561921592 no 1546 0.483154048907897 537 3071 Inhibits expression of several cancer promoting factors. SGTC_589 1227-0070 34.1 µM 0.0415379770732445 0.466312896752719 no 1547 0.483433508820491 536 2841384 SGTC_2745 rifampicin 24.3 µM 0.0412028187317273 0.466455517894897 no 1548 0.483567103279882 536 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2954 9074818 52.69 µM 0.0404302838704529 0.466784273827864 no 1549 0.483875043471837 528 16648742 SGTC_3242 9133940 49.47 µM 0.0404081694629005 0.466793685055283 no 1550 0.483883858640343 522 17248444 SGTC_469 w7 172 µM 0.0403974346046134 0.466798253495131 no 1551 0.483888137735194 535 45115570 A P450 inhibitor. SGTC_2132 5317594 122.667 µM 0.0398971626411242 0.467011159365527 no 1552 0.484087556594059 526 794577 SGTC_339 3091-4833 71.4 µM 0.0390282547795809 0.467380971795012 no 1553 0.484433930856632 526 3240077 SGTC_2702 st077768 96.8 µM 0.0384094559208392 0.467644353508435 no 1554 0.48468061090603 524 6484119 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0379358507881803 0.467845945439495 no 1555 0.484869414408127 527 94937 An inhibitor of serotonin biosynthesis. SGTC_805 3852-0218 479 µM 0.037679329598474 0.467955138162608 no 1556 0.484971678441301 529 6615355 SGTC_126 0417-1624 672.48 µM 0.0374663745210038 0.468045788041366 no 1557 0.485056575278967 532 41912 YDL195W SEC31 SGTC_79 0052-0007 94.094 µM 0.0361081082155462 0.468624008283693 no 1558 0.485598078562166 532 2801472 SGTC_519 k048-0011 62.8 µM 0.0355258141466529 0.468871913901381 no 1559 0.485830231325696 517 6836379 SGTC_1383 3049-0032 20.7 µM 0.0353102296907183 0.468963699798265 no 1560 0.485916183152544 537 712864 SGTC_197 4544-0043 41.561 µM 0.0342374642734855 0.469420458159948 no 1561 0.486343895936224 517 896523 SGTC_1767 st044992 70.3 µM 0.0340176332490201 0.469514062044068 no 1562 0.486431544769544 537 9600693 SGTC_2077 5212015 200 µM 0.0333520584736377 0.469797473532367 no 1563 0.486696920084051 525 780900 SGTC_1206 3978-0017 132 µM 0.0330087923984586 0.469943647245159 no 1564 0.486833788071691 525 3873677 SGTC_2275 7947463 200 µM 0.032062424118115 0.470346662152685 no 1565 0.487211134601546 535 1225414 SGTC_2238 6671620 73.2395 µM 0.0317226677084055 0.470491356278613 no 1566 0.487346608882461 529 729941 SGTC_165 k038-0023 64.381 µM 0.0316244143125293 0.470533200776226 no 1567 0.487385786659492 527 46368543 SGTC_1215 3852-0577 11.2 µM 0.0311596774240065 0.470731128938441 no 1568 0.487571098520657 532 2884876 SGTC_464 bw-b 70c 158 µM 0.0291690054477517 0.47157902330552 no 1569 0.488364900390028 532 5353454 SGTC_759 3486-0358 89.3 µM 0.0282583035217345 0.471966965169866 no 1570 0.488728068138577 538 875103 SGTC_1885 st057546 99.9 µM 0.0277183101157749 0.472197004772803 no 1571 0.488943409976707 524 702008 SGTC_1417 3966-0327 90.4 µM 0.0277052641839549 0.472202562513082 no 1572 0.488948612552472 531 651118 SGTC_2815 7968870 71.43 µM 0.0275985721098865 0.472248014957139 no 1573 0.488991160262075 528 2977326 YHR190W ERG9 SGTC_2370 9071495 200 µM 0.0266966481922206 0.472632262627439 no 1574 0.489350843268045 534 21791103 SGTC_1974 st069448 26.9 µM 0.0265608039843201 0.472690138705276 no 1575 0.489405018055303 532 6323587 YNR016C ACC1 SGTC_1302 1159-0335 255 µM 0.0261160630407028 0.472879623475865 no 1576 0.489582382489392 535 649284 SGTC_2194 5927483 104.545 µM 0.0260545310995677 0.472905840043716 no 1577 0.489606921832073 527 760979 SGTC_301 4119-0100 24.5 µM 0.0260474129788335 0.472908872828932 no 1578 0.489609760587962 534 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1515 3460-0031 42.1 µM 0.0252161946506782 0.473263036981424 no 1579 0.489941259800151 531 2876596 SGTC_1342 1486-1464 234 µM 0.0242345199867784 0.473681334524202 no 1580 0.490332771621108 533 3253938 SGTC_1334 1486-0610 236 µM 0.0234683800608371 0.474007811590603 no 1581 0.490638330295544 537 3742339 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0234589700664243 0.474011821603338 no 1582 0.490642083306933 537 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_967 1306-0166 352 µM 0.0231335995390401 0.474150477920802 no 1583 0.490771852147881 540 4437607 SGTC_1481 3346-2004 36 µM 0.0231064517869668 0.474162047049349 no 1584 0.490782679639774 537 2770522 SGTC_2108 5365811 200 µM 0.0227131964528588 0.474329636900457 no 1585 0.490939524652292 537 780283 SGTC_1761 st044296 37 µM 0.0197285999182229 0.475601699710228 no 1586 0.492129937890661 536 1826700 SGTC_1027 k015-0025 8.67 µM 0.0189966287130705 0.47591371112516 no 1587 0.492421897411392 536 3598955 SGTC_3138 9097216 49.47 µM 0.0188664693893502 0.475969194634079 no 1588 0.492473814164368 540 25237486 SGTC_987 1497-1013 404 µM 0.0186828273545092 0.476047477213462 no 1589 0.492547063825493 543 1676435 SGTC_3198 9112019 49.47 µM 0.0183268330530379 0.476199232421682 no 1590 0.492689060689197 541 45595555 SGTC_1366 1683-0113 21.9 µM 0.0161754226175362 0.477116420179187 no 1591 0.493547221404517 541 708623 SGTC_1175 0741-0056 27.6 µM 0.0161205916503237 0.477139797282767 no 1592 0.493569092943833 537 765927 SGTC_2804 7954240 19.48 µM 0.0159777366358501 0.477200703680879 no 1593 0.493626076509763 539 828705 SGTC_2821 7996764 71.43 µM 0.0149702880798491 0.477630245560138 no 1594 0.494027942201831 536 2987135 SGTC_1327 1436-0082 2.18 µM 0.0140513553813251 0.478022069958205 no 1595 0.494394504700765 530 15992205 SGTC_2616 abietic acid 100 µM 0.0131139602192812 0.478421788466584 no 1596 0.494768436755968 544 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1862 st057513 3.81 µM 0.0127657412184301 0.478570279506837 no 1597 0.494907344407728 540 5393163 SGTC_2844 9010103 25.97 µM 0.0117154934022332 0.479018154650397 no 1598 0.495326301259358 541 2480525 SGTC_968 1309-0633 340 µM 0.0101328936200144 0.479693099613502 no 1599 0.495957629487709 544 3761976 SGTC_427 1354-0053 47.3 µM 0.00968954465316096 0.479882188991151 no 1600 0.496134491447122 533 6813657 SGTC_530 4358-1714 28 µM 0.00949240107446434 0.479966272648086 no 1601 0.496213136738601 540 1564641 SGTC_3295 9122362 53.5725 µM 0.00389746712810412 0.482352923917959 no 1602 0.498445139512579 544 4730473 SGTC_2460 5552655 174.22 µM 0.00306095580018954 0.482709814030846 no 1603 0.498778857219771 545 5401989 SGTC_2289 7946404 165.07 µM 0.00290608368043697 0.482775890370874 no 1604 0.498840641981348 546 1246120 YPR165W RHO1 SGTC_558 k064-0027 21.3 µM 0.00135358272436796 0.483438292249281 no 1605 0.499459998786126 546 5088526 SGTC_1663 st014140 55.4 µM 0.00110304581279385 0.483545192567273 no 1606 0.499559948477293 548 4207120 SGTC_324 1315-0088 19.6 µM 0.000940660404861589 0.483614480601689 no 1607 0.499624730848344 547 6787421 SGTC_2749 bexarotene 57.39 µM 0.000185575665975019 0.483936673267386 no 1608 0.499925966021054 547 82146 An retinoic acid receptor inhibitor. SGTC_2008 4012253 172 µM 8.72508278575931e-05 0.483978628992697 no 1609 0.499965191955812 548 603940 SGTC_496 calpeptin 138 µM 2.76429338002602e-05 0.484004064080842 no 1610 0.499988972064954 548 73364 A calpain inhibitor. SGTC_963 1269-2853 151 µM -0.000508667781821485 0.484232914374932 no 1611 0.499797070923904 549 3668223 SGTC_3023 9089636 49.47 µM -0.000728017289143973 0.484326514973831 no 1612 0.499709563148153 548 17249241 SGTC_942 3253-1115 227 µM -0.000755250434000427 0.484338135934111 no 1613 0.49969869869823 549 46497897 SGTC_2701 st077767 14.721 µM -0.00182118598406233 0.484793003584453 no 1614 0.499273452312109 549 5721188 SGTC_1090 efavirenz 20.7 µM -0.00188100269981459 0.484818529818102 no 1615 0.499249588936009 548 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_143 4032-1194 15.74 µM -0.00253016253375546 0.485095556789739 no 1616 0.498990612265967 548 1806963 SGTC_2774 tamoxifen 10.92 µM -0.00307469467330803 0.485327939766681 no 1617 0.498773376228191 548 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2005 4024620 188 µM -0.00349239995075253 0.485506201856383 no 1618 0.498606736831812 550 236743 SGTC_2852 9023854 51.95 µM -0.0034986891958311 0.485508885909742 no 1619 0.498604227801367 549 19798528 SGTC_2120 5538279 151.968 µM -0.00373255458819742 0.485608692819635 no 1620 0.498510929618475 550 2058197 SGTC_3329 9141233 27.5565 µM -0.00538567371155816 0.486314221063834 no 1621 0.4978514374347 551 4909101 YNL103W MET4 SGTC_2403 6032726 181.2 µM -0.0060209636893195 0.486585365503831 no 1622 0.497597997528478 549 2881040 SGTC_1645 Cervolide 78 µM -0.00625454346782368 0.486685059903621 no 1623 0.497504814434412 551 23173 A fragrance. SGTC_1534 6-azauridine 81.6 µM -0.00654535308413484 0.486809181785253 no 1624 0.497388800559277 553 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_139 0099-0334 718.624 µM -0.00756639703522617 0.487244988612011 no 1625 0.496981473114332 553 97690 SGTC_3297 9117502 71.43 µM -0.00789288104212577 0.487384343304712 no 1626 0.496851228731618 553 7453720 SGTC_1605 st000082 49.1 µM -0.00808430221691209 0.487466049215727 no 1627 0.496774865168457 554 1114022 SGTC_2649 anisomycin 9.56 µM -0.00980543392354012 0.488200717567789 no 1628 0.496088260513684 554 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3045 9092950 49.47 µM -0.00987031381024731 0.488228412469947 no 1629 0.496062378436246 556 44120432 SGTC_2873 9040596 71.43 µM -0.012877507806703 0.489512136060878 no 1630 0.494862759655038 552 6463863 SGTC_1666 st014829 29 µM -0.0132486360727843 0.489670572653736 no 1631 0.494714713531214 557 3858230 SGTC_2240 6690706 185.951 µM -0.0134573302555864 0.48975966600664 no 1632 0.494631464020286 551 805876 SGTC_965 1291-5240 308 µM -0.0146672879306122 0.49027621733905 no 1633 0.494148808500232 560 2834598 SGTC_1725 st036284 20.55 µM -0.0151820099208758 0.490495965830333 no 1634 0.493943487006387 564 707914 SGTC_2149 5554786 194.827 µM -0.0162632780931154 0.490957597252408 no 1635 0.493512176750609 557 745063 YPR165W RHO1 SGTC_3175 9106517 49.47 µM -0.0167902316394042 0.491182576687701 no 1636 0.493301981411287 558 41468073 SGTC_996 3970-0799 1.8 µM -0.0169520083756338 0.491251646793268 no 1637 0.493237451015738 553 6615648 YGL040C HEM2 SGTC_1789 tunicamycin 25 nM -0.0171824737762518 0.491350043776226 no 1638 0.493145522013473 554 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_775 4577-0580 57.3 µM -0.0172536680601971 0.491380440214543 no 1639 0.493117123813295 568 2006902 SGTC_1633 st005664 67.9 µM -0.0176798208806733 0.491562387433809 no 1640 0.492947139368595 561 2063822 SGTC_142 0335-0849 62.6745 µM -0.0177944716520575 0.491611338224287 no 1641 0.492901407522765 557 3889043 YPR107C YTH1 SGTC_2818 7996756 12.99 µM -0.0178773666458571 0.491646730785988 no 1642 0.49286834246466 555 2241621 SGTC_1701 st028638 40.4 µM -0.0189295722221397 0.492095982484045 no 1643 0.492448644271288 557 3490878 SGTC_3105 9121040 49.47 µM -0.0194863993869409 0.492333730564472 no 1644 0.492226543350724 557 41448907 SGTC_40 0327-0103 19.753 µM -0.0203122086936596 0.492686330739441 no 1645 0.491897158333858 559 409036 SGTC_2389 9091542 195.52 µM -0.0208993933810054 0.492937047588784 no 1646 0.491662955265512 554 3626624 YOL127W RPL25 SGTC_2806 7952793 58.44 µM -0.0214675229526681 0.493179630917922 no 1647 0.49143635520951 558 2972490 SGTC_3330 9141424 71.43 µM -0.0224066997283837 0.493580651668119 no 1648 0.491061768042089 557 27261020 SGTC_3118 9124250 49.47 µM -0.0224149200777908 0.493584161718863 no 1649 0.491058489420589 559 1504786 SGTC_2491 paeonol 100 µM -0.0225048491680321 0.493622561052108 no 1650 0.491022621952015 561 11092 Increases levels of cortical cytochrome oxidase. SGTC_2286 7945697 125 µM -0.0226498481940182 0.493684475134445 no 1651 0.490964790451279 563 1245733 SGTC_1713 st033146 12.748 µM -0.0228568242228075 0.493772853445723 no 1652 0.490882240333968 564 674619 SGTC_2610 ononetin 44.17 µM -0.0254885547737393 0.494896621805578 no 1653 0.489832638745218 569 259632 SGTC_2343 7990716 14.84 µM -0.0258489515004107 0.495050517219115 no 1654 0.489688908612615 555 6456862 SGTC_1035 k081-0041 55.2 µM -0.0260020253373143 0.495115882524877 no 1655 0.489627861506383 556 731709 SGTC_3055 9094636 49.47 µM -0.0263193574119114 0.495251389494167 no 1656 0.48950130763842 564 25236176 SGTC_3133 9127736 49.47 µM -0.0282353440362924 0.49606956414013 no 1657 0.488737223994676 573 27243420 SGTC_1714 st033236 13.627 µM -0.0283949637174219 0.496137726566092 no 1658 0.48867357047731 572 2916566 SGTC_2899 9053889 58.44 µM -0.029391859013868 0.496563433446388 no 1659 0.488276032783558 556 6470052 SGTC_376 3970-0862 59.1 µM -0.0296682608857965 0.496681466794951 no 1660 0.488165812458701 569 3135186 SGTC_3217 9129673 49.47 µM -0.0302247625443118 0.496919113502744 no 1661 0.487943899948036 570 17248312 SGTC_2333 9017922 200 µM -0.0305169163772189 0.497043874394324 no 1662 0.487827401173043 565 3163164 SGTC_749 1000-0129 128 µM -0.0322179743796885 0.497770296754642 no 1663 0.487149111068733 563 708470 SGTC_2081 5214970 32.255 µM -0.0325274021631166 0.49790243612462 no 1664 0.487025731910746 569 2063512 SGTC_2020 4017018 200 µM -0.0327758517786913 0.498008535283087 no 1665 0.486926667676489 558 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3199 9111318 49.47 µM -0.0329045646221464 0.498063501511239 no 1666 0.486875346363189 566 8548020 SGTC_1571 st070080 73.4 µM -0.0330607479823972 0.498130198946584 no 1667 0.486813072099271 565 4315245 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0332010530096123 0.498190115652402 no 1668 0.486757129203278 563 4330530 SGTC_1618 st003135 44.5 µM -0.0339204751434671 0.498497342635609 no 1669 0.486470282889376 561 1270615 SGTC_3017 9080681 49.47 µM -0.0340529903834684 0.498553932959023 no 1670 0.486417447481231 565 16451914 SGTC_1236 0330-0013 258 µM -0.0347847551092206 0.498866431867323 no 1671 0.486125688467962 581 4617066 SGTC_798 1287-0182 476 µM -0.0351655202312296 0.499029037266239 no 1672 0.485973878043038 592 1649755 SGTC_2834 9001755 58.44 µM -0.0355235977337682 0.499181954085569 no 1673 0.485831114988737 578 2989575 SGTC_2151 5563267 85.4165 µM -0.0360285821742492 0.499397607638716 no 1674 0.485629784232357 558 5310824 SGTC_3273 9137859 49.47 µM -0.0360810450340896 0.499420011908765 no 1675 0.485608868178745 560 2377234 SGTC_747 3448-8087 38.7 µM -0.0361427739277364 0.499446373241904 no 1676 0.485584257965104 575 5168703 SGTC_353 1988-1175 58.3 µM -0.0369355701249725 0.499784937149394 no 1677 0.485268189114512 567 2788357 SGTC_3066 9117245 49.47 µM -0.0374173437986848 0.499990678865108 no 1678 0.485076122001128 574 17176980 SGTC_2263 7948595 193.29 µM -0.0374609973393135 0.499990678865108 no 1679 0.485058718959207 592 2971371 SGTC_2930 9013230 14.89 µM -0.0375775358718416 0.499940911017574 no 1680 0.485012259523189 568 2995857 SGTC_1291 0993-0025 5.79 µM -0.0384947662378324 0.49954920735475 no 1681 0.484646602164997 569 4353356 SGTC_2886 9058944 51.95 µM -0.039438117518399 0.49914634920003 no 1682 0.484270545075701 560 4949929 SGTC_1935 st074532 41.6 µM -0.0397781394993561 0.499001143008493 no 1683 0.484135002293612 584 2829742 SGTC_271 rotenone 740 µM -0.0398535943410575 0.498968920078977 no 1684 0.484104924018049 562 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_731 3966-0296 387 µM -0.0403876041911012 0.498740871806063 no 1685 0.483892056304791 576 660956 SGTC_3141 9094609 49.47 µM -0.0408245370523178 0.498554280448742 no 1686 0.483717888961515 575 25236309 YDL196W YDL196W SGTC_911 3456-4043 236 µM -0.0412350168591882 0.498378986105942 no 1687 0.483554268992842 561 914281 SGTC_17 0960-0276 49.807 µM -0.041448284251151 0.498287910937677 no 1688 0.483469260289917 563 6821114 SGTC_482 fipronil 114 µM -0.0422069047268856 0.497963945208048 no 1689 0.483166879145454 561 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_55 0767-0285 6.563 µM -0.0424361007079257 0.497866068268708 no 1690 0.483075525027582 567 3116166 SGTC_1552 6-methylflavone 10.6 µM -0.042831630187391 0.497697159788357 no 1691 0.482917874937297 562 689013 SGTC_364 0083-0097 67.7 µM -0.0429027371979004 0.497666794010981 no 1692 0.482889533396488 573 5207356 SGTC_1742 st038235 28.8875 µM -0.0430132931654304 0.49761958184498 no 1693 0.482845468623844 568 564103 YBR002C RER2 SGTC_2257 7960413 200 µM -0.0451845681418422 0.49669236138074 no 1694 0.481980097263057 572 2974689 YIL048W NEO1 SGTC_521 r062-0005 13.8 µM -0.0480682045357387 0.495460962829521 no 1695 0.480830943003222 566 2832033 SGTC_15 0266-0086 27.098 µM -0.048497851359976 0.495277494267203 no 1696 0.480659738397496 571 1712902 YIL048W NEO1 SGTC_704 1310-0270 142 µM -0.0489313411880731 0.495092385670882 no 1697 0.480487006056526 578 5718033 SGTC_414 piperonyl butoxide 100 µM -0.0495979391910839 0.494807737421177 no 1698 0.480221394449971 580 5794 A potent inhibitor of cytochrome P450. SGTC_3235 9132602 49.47 µM -0.0506486721407655 0.494359062690798 no 1699 0.479802738904363 581 4912240 SGTC_527 4476-4215 268 µM -0.0508420981434164 0.494276468383542 no 1700 0.479725672384574 560 4418754 SGTC_2010 4012422 159 µM -0.0508872142117468 0.494257203530016 no 1701 0.479707696945587 583 952393 SGTC_1208 2323-2347 50.3 µM -0.0511034790297104 0.49416485723813 no 1702 0.479621531876201 572 5412760 SGTC_2789 5281112 71.43 µM -0.0512054042569938 0.494121334701749 no 1703 0.479580922760887 571 765948 SGTC_1323 1348-1351 11.2 µM -0.0520868261396991 0.49374496651659 no 1704 0.479229754967451 564 6989654 SGTC_1081 sertraline 6 µM -0.0524176309934275 0.493603713872264 no 1705 0.479097962963749 569 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2654 protoveratrine a 100 µM -0.0527611516773656 0.493457032457033 no 1706 0.478961107417179 582 5702278 A heart drug and vasodilator. SGTC_932 2857-0803 154 µM -0.0531476093667041 0.49329201823851 no 1707 0.478807149120015 605 674898 SGTC_2295 7971645 200 µM -0.0537908283992496 0.493017371621405 no 1708 0.478550908409346 580 2978226 YKL099C UTP11 SGTC_1822 st052468 42 µM -0.0539466922054128 0.492950820186132 no 1709 0.478488817900997 572 2873678 SGTC_1252 0493-0875 34.8 µM -0.0541823837708143 0.49285018390524 no 1710 0.478394927890005 582 3960963 SGTC_662 k832-1615 104 µM -0.0544394123963549 0.492740437582322 no 1711 0.478292539421978 570 5878478 SGTC_438 sphingosine 6.67 µM -0.0547904530324619 0.492590550812574 no 1712 0.478152703177543 575 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2513 baicalein 25.65 µM -0.0551128468249589 0.492452896547385 no 1713 0.478024280707412 587 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1449 4112-4002 201 µM -0.0552492167273033 0.492394670203576 no 1714 0.477969959752816 573 2059539 SGTC_1763 st044482 94.5 µM -0.0560893432053857 0.492035962024772 no 1715 0.477635316732467 570 88505 SGTC_598 3937-0236 20.2 µM -0.0560894455548256 0.492035918325094 no 1716 0.477635275965126 566 1379313 SGTC_815 1582-0027 36.9 µM -0.0564824924596832 0.49186810157388 no 1717 0.477478721125624 571 3128206 SGTC_2707 st078556 66.6 µM -0.0568470842891043 0.49171243539242 no 1718 0.477333503357567 563 17250899 SGTC_3025 9087895 49.47 µM -0.0574813369263775 0.491441637814137 no 1719 0.477080886250094 577 17173641 SGTC_355 1311-2252 105 µM -0.0576073758099431 0.491387825300043 no 1720 0.477030687192739 571 5338538 SGTC_827 3253-0474 693 µM -0.058801618870567 0.490877949125497 no 1721 0.476555059510778 581 5402065 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0592964396072986 0.490666692176345 no 1722 0.476357998454383 578 1377 SGTC_938 3126-1755 342 µM -0.0596026768981635 0.490535949659182 no 1723 0.476236043152487 566 1777771 SGTC_2434 5670830 169.91 µM -0.060719327015722 0.49005922464386 no 1724 0.475791369673436 594 1549830 SGTC_2919 7978188 46.38 µM -0.0607889375260953 0.490029506692009 no 1725 0.475763650301924 564 2980291 SGTC_1638 st008370 60.6 µM -0.0611221523673968 0.489887252181993 no 1726 0.475630963547026 577 24207134 SGTC_2856 9022925 19.48 µM -0.0619586576364691 0.489530141002138 no 1727 0.475297877569847 577 4944862 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0619681467619894 0.489526090061737 no 1728 0.475294099216863 577 1273210 SGTC_247 mechlorethamine 29.705 µM -0.0622145561184917 0.489420897437408 no 1729 0.475195985419747 574 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_906 1165-0455 526 µM -0.0624189291988207 0.489333650737521 no 1730 0.475114610515359 598 3252859 SGTC_624 k048-0052 28 µM -0.062464961276917 0.489313999751521 no 1731 0.475096282139142 576 6835531 SGTC_2412 st077135 33.4 µM -0.0628144926860263 0.48916478646381 no 1732 0.474957112582686 638 13258915 SGTC_101 0490-5701 117.494 µM -0.0634314504260848 0.488901413867531 no 1733 0.474711471925422 582 4661669 SGTC_160 3453-0671 289.699 µM -0.0636469930498281 0.488809402184108 no 1734 0.474625656263605 593 5322268 SGTC_1018 4259-0013 28.1 µM -0.0641416500331487 0.488598243324302 no 1735 0.474428719087699 596 6801262 SGTC_46 0329-0187a 2.197 µM -0.0643684708421871 0.48850141926613 no 1736 0.474338417284742 578 46494817 SGTC_1127 asiatic acid 681.4 nM -0.0646182469988495 0.488394796935756 no 1737 0.474238978034143 589 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1163 k060-0048 49.9 µM -0.0652929637985855 0.488106783710456 no 1738 0.473970372233565 570 6809982 SGTC_2154 5570129 200 µM -0.0655494439950591 0.487997302819512 no 1739 0.473868270168384 584 673366 SGTC_608 k048-0125 159 µM -0.0664299138602527 0.487621473229229 no 1740 0.473517777489553 576 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_748 act1.228 77.9 µM -0.0673119835300084 0.487244971783193 no 1741 0.473166668524803 588 4421505 YNR035C ARC35 SGTC_1744 st037937 38.9 µM -0.0676564726352137 0.487097933579453 no 1742 0.473029549839571 592 1016152 SGTC_2296 7971656 126.45 µM -0.0686018596020739 0.486694423353459 no 1743 0.472653269303972 579 666570 SGTC_2924 9010168 62.78 µM -0.0702797108546162 0.485978316399652 no 1744 0.471985515481654 594 2993929 SGTC_3151 9099821 49.47 µM -0.0705493646769202 0.485863232298895 no 1745 0.471878205533697 616 17174189 SGTC_2879 9041815 71.43 µM -0.0715736939366377 0.485426075150209 no 1746 0.471470587783112 579 4942971 SGTC_453 enantio-paf c16 10 µM -0.0717431781937549 0.485353745341701 no 1747 0.471403146722251 595 13871343 A lipid and platelet activating factor SGTC_1113 artemisinin 1.17947 µM -0.0723873574738856 0.485078837121751 no 1748 0.471146822837189 600 2240 An anti-malaria and mitochondrial poison. SGTC_3340 9146634 11.102 µM -0.0738828257993489 0.484440662638084 no 1749 0.470551810761127 573 4907387 SGTC_154 3389-1638 511.116 µM -0.0758074909125146 0.483619392077513 no 1750 0.469786128195358 644 5238686 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0759731161974059 0.483548721593096 no 1751 0.469720243266816 590 5377381 SGTC_1271 0832-2808 169 µM -0.0760400939965266 0.483520143050722 no 1752 0.469693600061112 604 3663794 SGTC_3117 9124945 49.47 µM -0.0761705873642576 0.483464463497312 no 1753 0.469641691285743 582 17592065 SGTC_2411 st077133 39.94 µM -0.0770342356779105 0.48309596595818 no 1754 0.469298154872447 573 1403142 YNL221C POP1 SGTC_2496 diffractaic acid 79.83 µM -0.0771278565230394 0.483056021103114 no 1755 0.469260916349607 580 94870 An apoptosis inducer which activates caspases. SGTC_383 2324-0395 7.37 µM -0.0776550070895122 0.482831106933307 no 1756 0.469051242557715 598 3146421 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0789334988266892 0.482285648219201 no 1757 0.468542759073322 599 616764 SGTC_2375 9072683 200 µM -0.0793933154934911 0.482089479011518 no 1758 0.4683598926617 587 16798029 SGTC_2162 5663267 200 µM -0.0794909362555593 0.48204783212685 no 1759 0.468321070310694 624 6456493 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0804243378126846 0.481649635122849 no 1760 0.467949885410915 593 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_666 0272-0154 136 µM -0.0809974288753443 0.481405158670566 no 1761 0.467721998624104 582 6870312 SGTC_193 1273-0060 1.558 µM -0.0836357070019158 0.480279780154334 no 1762 0.466673038149438 618 2847393 YHR072W ERG7 SGTC_259 usnic acid 108.925 µM -0.0837341082657837 0.480237809297215 no 1763 0.466633918944054 628 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_617 3770-0098 35 µM -0.0840531138197399 0.480101746125558 no 1764 0.466507101207964 591 5962639 SGTC_429 1112-0049 25.5 µM -0.0840780538546776 0.48009110872722 no 1765 0.466497186668656 582 2836170 SGTC_1881 5652484 16 µM -0.0847920157457825 0.479786596469572 no 1766 0.466213370596453 627 2255129 SGTC_1309 pyrazolanthrone 13.4 µM -0.0861724755795304 0.479197849439392 no 1767 0.465664655302734 604 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1930 st074634 34.3 µM -0.0862613427291501 0.479159950370057 no 1768 0.465629333961726 604 684253 YOR116C RPO31 SGTC_2944 9067346 25.62 µM -0.086744245744408 0.478954010588685 no 1769 0.465437402962698 598 6473075 SGTC_1358 1509-0022 2.48 µM -0.0872670916104775 0.478731043036204 no 1770 0.465229605644732 586 3258434 SGTC_225 nsc-122657 1.016 µM -0.0874285198645127 0.478662203319531 no 1771 0.465165450297506 621 275685 SGTC_1172 0370-0043 85 µM -0.0874625526812669 0.478647690393199 no 1772 0.465151924979139 606 376585 SGTC_2681 menadione 3.18 µM -0.0883977959965544 0.47824887715011 no 1773 0.464780256490069 588 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_793 0488-0545 106 µM -0.0887777373904281 0.478086865981587 no 1774 0.464629275402844 586 292548 SGTC_900 1112-0045 141 µM -0.0889442063094095 0.478015882951926 no 1775 0.464563125597448 580 56211 YIL048W NEO1 SGTC_2407 paclitaxel 400 µM -0.0913437082889767 0.476992804057752 no 1776 0.463609744469009 680 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2252 omeprazole 400 µM -0.0919537439971676 0.476732726217539 no 1777 0.463367395380704 611 4594 A proton pump inhibitor. SGTC_653 0203-0016 55.2 µM -0.092112685773083 0.476664965850138 no 1778 0.463304254757368 598 295302 SGTC_829 1635-0120 117 µM -0.0931845601530161 0.476208019993103 no 1779 0.462878470113537 583 285054 SGTC_1568 digitonin 820 nM -0.0935065617604709 0.476070755046406 no 1780 0.462750568502667 606 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_230 MPP+ 141.667 µM -0.0941139034149262 0.475811861224364 no 1781 0.462509338037913 608 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2841 9004761 38.96 µM -0.0951268384905884 0.475380096332901 no 1782 0.462107040351447 587 2991039 SGTC_2483 5729050 27.16 µM -0.0960730845056237 0.47497678384699 no 1783 0.461731263928419 605 2865180 SGTC_1092 toremifene 6.32 µM -0.0962696019679157 0.474893026647155 no 1784 0.46165322652088 627 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1583 clindamycin 39.6 µM -0.0963472312047804 0.474859940796217 no 1785 0.461622400229843 604 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_125 0133-0007 11.75 µM -0.0964402353384127 0.474820302339062 no 1786 0.461585468926136 595 26541 SGTC_3225 9130819 49.47 µM -0.097380872781674 0.474419415770601 no 1787 0.461211966918746 609 4547121 SGTC_1272 0839-0021 27 µM -0.0985018967021749 0.473941684859751 no 1788 0.460766882967484 611 5027250 SGTC_3285 9112818 20.8695 µM -0.0992643739419936 0.473616772086169 no 1789 0.460464182075071 587 17017947 YPR165W RHO1 SGTC_213 1246-0773 967 nM -0.100128472944501 0.473248576677543 no 1790 0.4601211653881 609 6251622 SGTC_379 3970-0972 5.9 µM -0.100795344309552 0.472964436218131 no 1791 0.459856461361188 591 2898042 YBL034C STU1 SGTC_1716 st033144 30.6155 µM -0.101517250428297 0.47265686206861 no 1792 0.459569932219247 597 674617 SGTC_365 0121-0052 13.6 µM -0.10222616799681 0.47235483766429 no 1793 0.459288578749348 595 3101739 SGTC_1756 st041558 35.5 µM -0.102332341332144 0.472309605365634 no 1794 0.459246442687882 625 3955792 SGTC_1812 st052057 4.327 µM -0.102896629880877 0.472069211387792 no 1795 0.459022506234973 598 3645418 SGTC_2778 tioconazole 65.09 nM -0.102922346630082 0.472058255972808 no 1796 0.459012300918727 615 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1923 st058458 19.1 µM -0.103379709107259 0.471863421676897 no 1797 0.458830807819156 641 3534982 SGTC_476 mead acid 10 µM -0.103644496006765 0.471750626759104 no 1798 0.458725737541646 591 5312531 An omega 9 fatty acid. SGTC_2200 6600604 21.907 µM -0.103867539667529 0.471655615540662 no 1799 0.458637233665475 615 2904777 SGTC_2522 biochanin a 4.94 µM -0.104191443294744 0.47151764328339 no 1800 0.45850871213796 610 5280373 A possible chelator. SGTC_848 0368-0089 85.6 µM -0.104196084875584 0.471515666147916 no 1801 0.458506870439351 597 762535 SGTC_1389 3405-0187 19 µM -0.104231935528434 0.471500395168007 no 1802 0.458492645553374 599 799890 SGTC_2874 9043904 71.43 µM -0.105868334953556 0.470803397794756 no 1803 0.457843408943887 604 4463428 SGTC_2265 7929201 200 µM -0.108214670792483 0.46980417127959 no 1804 0.456912703843645 623 1265108 SGTC_2978 9011784 42.97 µM -0.108520794060703 0.469673817432316 no 1805 0.456791293322695 602 2994934 SGTC_2803 7707263 71.43 µM -0.108553988393515 0.469659682769187 no 1806 0.456778128472064 604 2199229 SGTC_1728 st035614 33.7865 µM -0.111352162308528 0.468468316026535 no 1807 0.455668546507017 613 15945546 SGTC_2249 haloperidol 116.36 µM -0.111702145240067 0.468319324910678 no 1808 0.455529789161068 598 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2013 4024628 200 µM -0.112002847384863 0.468191316645174 no 1809 0.455410574446037 613 5230760 SGTC_1793 st048256 72.231 µM -0.112431890534026 0.468008679583283 no 1810 0.455240485317539 598 672022 SGTC_1306 1185-0270 9.02 µM -0.112769160242562 0.467865113787017 no 1811 0.45510678445234 609 1548076 SGTC_358 0075-0058 9.45 µM -0.113614256713733 0.467505399470408 no 1812 0.454771792655697 669 1069125 SGTC_1019 4262-0212 3.4 µM -0.113999308934036 0.467341511228223 no 1813 0.454619170632069 595 4677213 SGTC_1176 0848-0131 83.3 µM -0.114486795997998 0.467134031996316 no 1814 0.454425956421233 599 6769040 SGTC_1939 st074455 53.6 µM -0.116696832111698 0.46619353198195 no 1815 0.453550150366528 584 1644229 SGTC_1422 4031-0024 15.5 µM -0.116900847181615 0.466106721038229 no 1816 0.453469313401906 609 782427 SGTC_210 3551-0445 56.827 µM -0.117465368960526 0.465866518433841 no 1817 0.453245642792247 635 2865180 YOR207C RET1 SGTC_854 0422-0053 192 µM -0.117494143417903 0.465854275306535 no 1818 0.453234242387976 596 3596728 SGTC_1810 st050138 53 µM -0.117874398696461 0.46569248506823 no 1819 0.45308358934266 601 3444541 SGTC_1500 4488-1866 171 µM -0.118036991117556 0.465623307306476 no 1820 0.453019174036509 616 2900003 SGTC_228 caffeine 993.056 µM -0.118487247272935 0.465431743454212 no 1821 0.452840799558569 612 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_58 0957-0393 9 µM -0.119065918102015 0.465185556671822 no 1822 0.452611566017385 598 6997992 SGTC_289 k017-0060 526 µM -0.119089898144378 0.465175355011111 no 1823 0.452602066950142 611 5512909 SGTC_2638 epoxomicin 18 µM -0.119413807284929 0.465037558869639 no 1824 0.452473761467157 616 9915668 A protesome inhibitor. SGTC_2931 9014674 55.67 µM -0.119518885124199 0.464992857971993 no 1825 0.452432139554952 605 2996810 SGTC_807 1315-0151 48 µM -0.11961815975806 0.464950626207114 no 1826 0.452392816804649 635 4011080 SGTC_2281 7943571 200 µM -0.120111452789978 0.464740783547643 no 1827 0.452197430030047 595 1244024 SGTC_72 0744-0168 198.391 µM -0.120446236715268 0.464598374895958 no 1828 0.452064833184725 660 677577 SGTC_3153 9100258 49.47 µM -0.12059947993047 0.464533190602818 no 1829 0.452004140396113 618 25236848 SGTC_1149 3909-7961 23.3 µM -0.121163731105133 0.464293186146357 no 1830 0.451780675403328 587 735261 SGTC_395 anisomycin 6.25 µM -0.122434971022049 0.463752511494088 no 1831 0.451277271983972 627 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3202 9113761 49.47 µM -0.122493943800076 0.463727431231704 no 1832 0.451253921011215 608 4798415 SGTC_1708 st033234 31.827 µM -0.12281740733365 0.46358986947491 no 1833 0.451125844780635 599 674664 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.124372321378224 0.462928660595292 no 1834 0.450510243754634 601 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1530 rhein 70.4 µM -0.126236826061285 0.46213593712585 no 1835 0.449772230771007 593 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2039 Aminomethylbenzodioxan 200 µM -0.12637757594091 0.462076101167714 no 1836 0.449716525814806 627 15053 SGTC_808 0711-0032 135 µM -0.12780672669935 0.461468585682472 no 1837 0.44915096329438 604 4252555 SGTC_513 4245-1575 41.7 µM -0.129566474938642 0.460720660672504 no 1838 0.448454714366612 603 719745 SGTC_2297 7971671 152.32 µM -0.129845166246835 0.460602224473146 no 1839 0.448344463937035 617 909016 SGTC_566 0958-0068 16.5 µM -0.130060198669488 0.460510843950731 no 1840 0.448259399722631 635 6815365 SGTC_65 0798-0905 34.986 µM -0.131067418514829 0.460082842033738 no 1841 0.447860987518858 701 3602145 SGTC_1073 triclabendazole 3.09 µM -0.131154141120183 0.46004599280907 no 1842 0.447826686295199 616 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1910 st062352 60.4 µM -0.131197821158738 0.460027432892891 no 1843 0.447809409762111 603 2245730 SGTC_1390 3413-2614 145 µM -0.131305676407328 0.459981604909651 no 1844 0.447766750774002 637 3421432 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.132203162410906 0.459600281384536 no 1845 0.447411799918162 599 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1745 st081495 74 µM -0.132231531502563 0.459588228539288 no 1846 0.447400580781128 598 13842402 YBL026W LSM2 SGTC_371 0195-0006 7.36 µM -0.132943711042019 0.459285665319223 no 1847 0.44711894864173 601 3928593 SGTC_2878 9043973 25.97 µM -0.137127770712388 0.457508586252702 no 1848 0.44546490097834 612 6465167 SGTC_1475 4092-1048 11.7 µM -0.138270147708816 0.457023535091125 no 1849 0.4450134587693 606 2881759 SGTC_83 0170-0301 39.027 µM -0.138420803202276 0.456959571809531 no 1850 0.444953928348221 601 3089716 SGTC_2895 9054447 58.44 µM -0.138928106279859 0.456744196105642 no 1851 0.444753480367516 597 2697450 SGTC_2219 9098279 200 µM -0.139494233584264 0.456503861559374 no 1852 0.444529806162521 599 902349 SGTC_722 3534-0461 190 µM -0.140069370788922 0.456259718388513 no 1853 0.444302590276266 600 658262 SGTC_1283 0922-0125 16.4 µM -0.141020821787348 0.455855867992712 no 1854 0.443926746655787 601 3360884 SGTC_1285 0929-0069 65.5 µM -0.141105641457512 0.455819867865803 no 1855 0.443893243503778 610 1206237 SGTC_1934 st074720 32.6 µM -0.141197468512545 0.455780893994011 no 1856 0.443856972937826 604 17250992 SGTC_1755 st041960 45.185 µM -0.141306747345767 0.455734513672719 no 1857 0.443813809745347 618 2257073 SGTC_2719 novobiocin 32.65 µM -0.142329989281491 0.455300256821758 no 1858 0.443409679816 610 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2092 5303694 80.6725 µM -0.143080891807725 0.454981612892061 no 1859 0.443113147894474 637 1963699 SGTC_191 3914-0123 66.505 µM -0.143139198054314 0.454956871966405 no 1860 0.443090124048568 641 3144412 SGTC_2991 9074669 71.4286 µM -0.143478988243021 0.45481269323019 no 1861 0.442955952251149 615 17333109 SGTC_3186 9110464 49.47 µM -0.14591792613832 0.453777986386194 no 1862 0.44199309002224 621 17018021 SGTC_2148 5546263 113.568 µM -0.146281387541294 0.453623816441454 no 1863 0.441849629195113 625 792097 SGTC_952 1185-0122 232 µM -0.147390013373645 0.45315361229623 no 1864 0.441412093805217 599 678600 SGTC_2942 9052777 62.25 µM -0.147840451854606 0.452962585463103 no 1865 0.441234342068259 595 6469503 SGTC_1667 st014849 34.6 µM -0.149210241453467 0.452381737308384 no 1866 0.440693869474419 604 5348460 SGTC_2555 cholic acid 100 µM -0.150177163440747 0.451971783168495 no 1867 0.440312421243159 608 6708657 Influences liver metabolism. SGTC_302 1094-0063 18.9 µM -0.151231589973845 0.451524787361922 no 1868 0.439896515837341 626 5440289 SGTC_2658 polymyxin b sulfate 77.05 µM -0.151631242005778 0.451355381647508 no 1869 0.439738895380427 613 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1361 1608-0041 5.61 µM -0.152977948070433 0.450784601197974 no 1870 0.439207832737479 607 X1361 SGTC_2248 tofa 1.1 µM -0.153863837446393 0.450409186158254 no 1871 0.438858549020466 623 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3158 9100007 49.47 µM -0.154651063229023 0.450075619197657 no 1872 0.438548205796647 621 19297233 SGTC_2365 9042475 200 µM -0.155171649919991 0.449855053147696 no 1873 0.438342998818555 612 6464479 SGTC_2992 9074591 71.4286 µM -0.156476415441798 0.449302308577194 no 1874 0.437828753996355 600 17741321 SGTC_1352 1496-0991 99 µM -0.156851948383057 0.449143237796829 no 1875 0.437680765310803 622 3000039 SGTC_3239 9133757 49.47 µM -0.157186142039371 0.44900168466282 no 1876 0.437549074793191 633 17036923 SGTC_221 trifluoperazine 10.304 µM -0.157346200922305 0.448933891429231 no 1877 0.437486005317515 615 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3293 9120939 62.045 µM -0.158422298398582 0.448478147171502 no 1878 0.437062022033671 643 934087 SGTC_2334 9017922 200 µM -0.159646070206187 0.447959943155673 no 1879 0.436579942800805 610 3163164 SGTC_2626 ethyl orsellinate 100 µM -0.159810963198449 0.447890126277737 no 1880 0.436514993849426 618 75653 A natural product. SGTC_1297 1068-0111 14.1 µM -0.160165814102271 0.447739885332617 no 1881 0.436375229046404 606 767057 SGTC_534 k292-0788 63.4 µM -0.160497918217581 0.447599281981424 no 1882 0.436244430695817 644 4146317 SGTC_1804 st050076 49.1 µM -0.160815240131499 0.447464943141045 no 1883 0.436119460790055 610 3895976 SGTC_591 4299-0174 154 µM -0.161299474250133 0.447259953319108 no 1884 0.435928768663043 626 5509088 SGTC_2647 atorvastatin 60.16 µM -0.161392517817153 0.447220566991318 no 1885 0.435892129670356 639 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2428 5615643 7.78 µM -0.161720877630612 0.447081572965421 no 1886 0.435762831494412 619 2253075 SGTC_237 nikkomycin 200 µM -0.162654904431565 0.44668623695934 no 1887 0.435395077541612 640 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2678 equilin 100 µM -0.163303073206916 0.446411924281731 no 1888 0.435139907158121 605 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_61 0978-8327 98.565 µM -0.163729789616417 0.446231346849058 no 1889 0.434971932639343 650 6150059 YHR072W ERG7 SGTC_2191 5911152 200 µM -0.164062913182498 0.4460903836927 no 1890 0.434840808573076 623 2875902 SGTC_909 3448-9333 149 µM -0.164324144736069 0.445979846821113 no 1891 0.434737987646419 628 3344074 SGTC_658 3253-0951 102 µM -0.164450520118242 0.44592637416162 no 1892 0.434688247789089 635 1184878 SGTC_2357 9067248 200 µM -0.164575923013123 0.445873313958565 no 1893 0.434638891713071 648 9150235 SGTC_317 4495-0002 170 µM -0.164597005500683 0.445864393676948 no 1894 0.434630594166833 631 15991618 SGTC_2536 dehydroabietamide 32.04 µM -0.165050177590022 0.445672657155295 no 1895 0.434452243795863 634 3983547 SGTC_3316 9136639 10.545 µM -0.165972678931773 0.44528238734055 no 1896 0.43408922549585 646 4903665 SGTC_661 1304-0007 33.6 µM -0.166510092004811 0.44505505588239 no 1897 0.433877770883146 620 3117130 SGTC_1251 0490-5699 265 µM -0.166795092828226 0.444934504823332 no 1898 0.433765639977447 615 3883818 SGTC_1802 st050112 57.9 µM -0.1668624364829 0.444906020214347 no 1899 0.43373914502523 606 4662563 SGTC_734 2023-0417 80 µM -0.168482596664958 0.444220820812461 no 1900 0.43310181690507 642 3935732 SGTC_398 bronopol 33.3 µM -0.168783548694161 0.444093560242342 no 1901 0.432983449452934 633 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1117 retinoic acid 1.10837 µM -0.169569238642226 0.443761350603753 no 1902 0.43267445807845 621 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_352 k048-0007 5.11 µM -0.170184969513836 0.443501031580795 no 1903 0.432432335938943 664 6811911 SGTC_618 k072-0232 33.2 µM -0.171091752504332 0.443117705811493 no 1904 0.432075810402188 642 5872756 YGL099W LSG1 SGTC_1525 8-methoxypsoralen 92.5 µM -0.171112307518053 0.443109017174555 no 1905 0.432067729298952 676 4114 Related to psoralen; DNA damaging agent. SGTC_1237 0330-0133 46.1 µM -0.171218132063305 0.443064285404299 no 1906 0.432026125345846 652 X1237 YHR072W ERG7 SGTC_2236 dapsone 200 µM -0.171948104739138 0.44275574757895 no 1907 0.431739163815817 614 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_683 panaxydol 45 µM -0.172544905967019 0.442503523161971 no 1908 0.431504580426504 610 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_850 0388-0143 75.9 µM -0.173110534112852 0.442264494843826 no 1909 0.431282272468329 626 67273 SGTC_1484 3473-2379 286 µM -0.173765845766089 0.441987593534832 no 1910 0.431024743560937 621 671917 SGTC_3355 9151058 44.0485 µM -0.174640766866644 0.441617940672812 no 1911 0.430680956742509 613 17015728 SGTC_583 1488-1091 88.9 µM -0.175004412710394 0.441464315784775 no 1912 0.430538083127294 650 4303273 SGTC_2287 7945887 168.79 µM -0.17535441508035 0.441316462999868 no 1913 0.430400578513132 639 1245853 SGTC_323 4013-0906 34.3 µM -0.17559803240847 0.441213555664249 no 1914 0.430304874122297 620 2910086 SGTC_3348 9149464 3.537 µM -0.176081226952584 0.441009459341516 no 1915 0.430115064605694 625 1951442 SGTC_2367 9070478 135.38 µM -0.177237461227854 0.440521141772115 no 1916 0.429660935814038 617 572802 SGTC_2700 st077718 96.8 µM -0.177465879753298 0.440424683434042 no 1917 0.429571231914492 624 904970 SGTC_634 1611-4317 11.2 µM -0.178139130012671 0.440140398704722 no 1918 0.429306856081636 634 2843522 SGTC_1739 st037196 92.5 µM -0.178953310457226 0.439796646432359 no 1919 0.428987181328817 646 612214 SGTC_392 N-ethylmaleimide 8.33 µM -0.179738553554332 0.439465154683661 no 1920 0.42867891247385 615 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1196 1588-0294 184 µM -0.180233403940094 0.43925627451273 no 1921 0.428484667629701 651 6144269 SGTC_1029 k015-0030 64.7 µM -0.18207797187875 0.438477817607664 no 1922 0.427760767827898 637 2208316 SGTC_179 1273-0063 6.77 µM -0.182246138084364 0.438406858771239 no 1923 0.427694783136408 667 3108139 SGTC_1672 st016598 6.51 µM -0.182337750045103 0.438368203334899 no 1924 0.427658837484486 674 4665860 YNL267W PIK1 SGTC_3230 9131665 49.47 µM -0.182378779497366 0.438350891251358 no 1925 0.427642739012576 629 15943720 SGTC_2221 6807166 181.081 µM -0.182792364341026 0.438176388682098 no 1926 0.427480470022312 624 674925 SGTC_2396 5342950 42.78 µM -0.183652561000502 0.43781348711308 no 1927 0.427143013311271 606 1886677 SGTC_870 0573-2213 57.6 µM -0.184454690888934 0.437475129990222 no 1928 0.426828384325189 617 3916321 SGTC_587 k089-0003 57 µM -0.186117048291202 0.436774054639811 no 1929 0.426176486444696 621 9659696 SGTC_1415 3966-0071 78.1 µM -0.186240359039617 0.436722057985989 no 1930 0.42612813781933 646 2893185 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.187021308679307 0.436392779040906 no 1931 0.425821962898869 638 229346 A bile salt which induces apoptosis. SGTC_517 1365-0151 113 µM -0.188210713359637 0.435891364211967 no 1932 0.425355737260975 651 768657 SGTC_621 3584-0052 32.1 µM -0.189049556551929 0.435537796756908 no 1933 0.425026988253213 668 2273927 SGTC_771 0250-0039 27.3 µM -0.189749772420912 0.435242699342204 no 1934 0.424752608254445 643 3005115 SGTC_2533 agelasine 13.65 µM -0.189756437020145 0.435239890801353 no 1935 0.424749996902253 632 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1467 k284-1082 293 µM -0.190004355254896 0.435135417450702 no 1936 0.424652858851036 652 3334705 SGTC_1902 st060212 70.5 µM -0.190322546752992 0.435001337410945 no 1937 0.424528193395907 620 688944 SGTC_503 tyrphostin 8 294 µM -0.190352980085995 0.434988513756019 no 1938 0.42451627020019 672 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_226 1,3-diallylurea 8.28947 mM -0.191493295285244 0.434508069986778 no 1939 0.424069566466781 630 74537 YKL182W FAS1 SGTC_1396 3511-0007 98.6 µM -0.192439656192387 0.434109417488262 no 1940 0.423698915854929 640 X1396 SGTC_1640 st009078 66.4 µM -0.192858913149968 0.43393282778889 no 1941 0.423534731718321 649 690618 SGTC_2304 7443016 91.4 µM -0.193125971450228 0.43382035055262 no 1942 0.423430156624955 636 939854 SGTC_1573 oleylamine 1.06 µM -0.193196168720105 0.433790786380743 no 1943 0.423402669566652 655 5356789 An amine of the fatty acid oleic acid. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.193224203991079 0.433778979193568 no 1944 0.423391691934368 626 5106787 A p450 inhibitor. SGTC_2025 5147754 141 µM -0.195385785586771 0.432868797570267 no 1945 0.422545471812646 644 315777 YLR208W SEC13 SGTC_1957 st077035 62.4 µM -0.195900539651007 0.4326521013214 no 1946 0.422344007436171 641 705593 SGTC_1512 0259-0544 12.2 µM -0.196185909033886 0.432531977966694 no 1947 0.422232328354962 620 18476 SGTC_785 1270-0111 65.3 µM -0.196905331048172 0.432229172247126 no 1948 0.421950810890217 622 6741994 SGTC_2937 9044753 11.33 µM -0.1971600829491 0.432121956354085 no 1949 0.421851133322444 611 6465530 YGL099W LSG1 SGTC_397 arbidol 50 µM -0.198222578133484 0.431674844415747 no 1950 0.421435461583806 619 131410 A RNA synthesis inhibitor. SGTC_2918 7977171 22.06 µM -0.200302252010431 0.430799944124482 no 1951 0.420622100694626 626 2236483 SGTC_2703 st077852 53.4 µM -0.200612367227796 0.430669510396954 no 1952 0.420500843508655 667 6281836 SGTC_1587 estradiol valerate 56.1 µM -0.200683875691187 0.430639435178753 no 1953 0.420472884276798 657 13791 A steroid. SGTC_1442 4112-3290 3 µM -0.20125060484803 0.430401092976983 no 1954 0.420251311953945 638 704353 SGTC_3044 9093193 49.47 µM -0.201293780473955 0.43038293618161 no 1955 0.4202344327498 682 25236277 SGTC_1445 4239-0156 97.7 µM -0.201791145871504 0.430173788013214 no 1956 0.420040001867888 678 4008346 SGTC_1548 st061468 90.8 µM -0.202744052134571 0.429773134166629 no 1957 0.419667544762199 632 390799 SGTC_1341 1486-1360 280 µM -0.202809126150858 0.429745776128538 no 1958 0.419642112268696 641 3976547 SGTC_3277 9138724 49.47 µM -0.202831680769978 0.429736293925939 no 1959 0.41963329745842 634 15943418 SGTC_1400 3771-8998 51.5 µM -0.203340491374703 0.429522395298264 no 1960 0.41943445450553 623 670767 SGTC_363 0455-0021 3.06 µM -0.204137584797171 0.42918734722085 no 1961 0.419122992134031 647 4597466 SGTC_448 monastrol 171 µM -0.204468960314558 0.429048072736394 no 1962 0.418993522835667 640 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2855 9016525 58.44 µM -0.204544335760386 0.429016394270754 no 1963 0.41896407467206 643 43811474 SGTC_509 pifithrin 175 µM -0.205897218298735 0.42844788860294 no 1964 0.418435599186774 623 4817 A p53 inhibitor. SGTC_110 0850-0284 111.64 µM -0.206093039058937 0.428365613455178 no 1965 0.418359118043231 623 3906265 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.207715870419763 0.427683892259702 no 1966 0.417725412571199 650 390807 SGTC_2000 st075254 36.4 µM -0.209086788806628 0.427108163099921 no 1967 0.417190243892546 633 17234175 SGTC_879 0831-1030 162 µM -0.209560568907694 0.426909231035207 no 1968 0.417005328839142 625 1549252 SGTC_2035 5154463 94.595 µM -0.211777844425239 0.425978483280265 no 1969 0.416140177032487 655 2769623 SGTC_415 dibenzyl ketone 100 µM -0.21229795806315 0.425760214203177 no 1970 0.415937294177712 667 7593 SGTC_1013 4112-3890 241 µM -0.212424144861184 0.425707262517284 no 1971 0.415888075351778 641 705171 SGTC_1224 0823-0416 294 µM -0.212798290826817 0.425550267762357 no 1972 0.415742148468039 658 3598164 SGTC_2629 bisabolol 100 µM -0.213359219648537 0.425314919488649 no 1973 0.415523393071181 647 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.214364902126961 0.424893033101542 no 1974 0.41513125476123 657 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3208 9114115 49.47 µM -0.214637801937598 0.424778565745286 no 1975 0.415024859527233 679 650895 SGTC_2316 5844804 197.44 µM -0.215180998507601 0.424550741764439 no 1976 0.41481310246352 668 776813 SGTC_2382 9035899 200 µM -0.215209215934605 0.424538907682282 no 1977 0.414802102997086 671 6462679 SGTC_2129 girgensonine 121.053 µM -0.215477452956002 0.424426415389482 no 1978 0.414697544563736 663 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2332 7982454 138.89 µM -0.216759313134612 0.423888918558391 no 1979 0.41419796074451 670 2981748 SGTC_2892 9047358 58.44 µM -0.216771645809568 0.42388374803001 no 1980 0.414193154961095 660 6466771 SGTC_2364 9055074 200 µM -0.216945161733197 0.423811002103097 no 1981 0.414125540826287 661 6470630 SGTC_1747 st037496 66.6 µM -0.217531269725967 0.423565297645934 no 1982 0.413897170330284 629 723305 SGTC_961 1252-1571 372 µM -0.21853471752326 0.423144707696616 no 1983 0.41350625562938 665 6813498 SGTC_1841 st054148 70 µM -0.218740387114051 0.423058513150804 no 1984 0.41342614318293 679 675442 SGTC_462 ag-879 158 µM -0.219286926224047 0.422829480714951 no 1985 0.413213272718267 674 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1611 st001856 99.4 µM -0.219913827589944 0.422566803828973 no 1986 0.412969133530204 676 647478 SGTC_3123 9126162 49.47 µM -0.220329115818945 0.422392813558595 no 1987 0.412807423056703 618 25239884 SGTC_3300 9124615 50.48 µM -0.22153853897504 0.421886196769007 no 1988 0.412336566110087 653 24824903 SGTC_367 0335-0881 7.1 µM -0.222208468467677 0.421605624729257 no 1989 0.41207580101189 677 23828853 SGTC_1653 st012112 65 µM -0.223571814092901 0.421034767289783 no 1990 0.411545248806006 643 720429 SGTC_2400 5203494 178.7 µM -0.223883128422366 0.420904437591007 no 1991 0.411424122048532 625 6777674 SGTC_510 ag-490 170 µM -0.224254250963852 0.420749080904094 no 1992 0.411279736032329 654 5328779 SGTC_3331 9141060 1.957 µM -0.224894627664367 0.420481039984929 no 1993 0.4110306243775 654 4906567 YPR165W RHO1 SGTC_1332 1480-0653 17.5 µM -0.225158824914784 0.420370466319759 no 1994 0.410927859983095 663 5749438 SGTC_1134 3477-0009 42.5 µM -0.22516909223576 0.420366169296181 no 1995 0.410923866442545 617 3973534 SGTC_2520 obtusaquinone 4.71 µM -0.226197278632619 0.419935906439324 no 1996 0.410523993551437 624 5967872 SGTC_1970 st070122 35.8 µM -0.227680892050896 0.419315230817189 no 1997 0.409947164128358 690 102928 SGTC_2492 derrusnin 100 µM -0.227865552225925 0.41923799150714 no 1998 0.409875381795215 680 1715307 Part of coumarin class of compounds. SGTC_756 0508-1999 28.3 µM -0.227973537792352 0.419192824949826 no 1999 0.409833406326021 651 6753853 SGTC_357 1325-0123 420 µM -0.229587938891932 0.418517705138559 no 2000 0.40920598995963 695 1098503 SGTC_2073 5212005 126 µM -0.230210192436884 0.418257551423556 no 2001 0.408964221062453 656 691789 SGTC_2018 5133068 143 µM -0.230548717446229 0.418116034835624 no 2002 0.40883270590798 666 785362 SGTC_1479 0549-0158 134 µM -0.234440337996338 0.416489952301006 no 2003 0.407321572936226 662 5440202 SGTC_2099 5377090 177.372 µM -0.235545077543344 0.416028604743741 no 2004 0.406892848010499 670 2243829 SGTC_2242 6630449 61.2675 µM -0.23705648167378 0.415397618512 no 2005 0.406306486370024 664 691249 YDR170C SEC7 SGTC_1900 st060200 72.8 µM -0.23760440595212 0.415168922969899 no 2006 0.406093966458684 631 688945 SGTC_672 1441-0018 53.7 µM -0.237709299663888 0.415125145151244 no 2007 0.406053285153895 647 251141 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.239325180477423 0.414450884174025 no 2008 0.405426720724261 657 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2423 st077119 87.2 µM -0.239947998698552 0.414191067072079 no 2009 0.405185284996425 630 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_313 3474-0040 5.03 µM -0.240007286590491 0.414166336276141 no 2010 0.405162303901132 642 1043375 YIL048W NEO1 SGTC_156 3474-0145 5.642 µM -0.240478391765861 0.41396983598022 no 2011 0.404979706357014 631 2265471 SGTC_2134 5324836 1.464 µM -0.24109719747749 0.413711761791702 no 2012 0.404739892405768 627 699272 SGTC_468 gf-109203x 121 µM -0.242297839460165 0.413211137989167 no 2013 0.404274693883863 660 2396 A protein kinase C inhibitor. SGTC_2891 9063876 19.48 µM -0.244209264100678 0.412414435205543 no 2014 0.403534376266743 635 6472478 SGTC_665 3914-0008 307 µM -0.245218807147531 0.41199379194997 no 2015 0.40314350743858 682 1069549 SGTC_1613 st002381 52.1 µM -0.245700745404617 0.411793019811541 no 2016 0.402956947566902 636 551167 SGTC_2583 asiatic acid 100 µM -0.246642324989893 0.411400830950402 no 2017 0.402592522812675 672 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3001 9076041 71.4286 µM -0.247081919454093 0.411217760354298 no 2018 0.402422413093602 661 16004211 SGTC_1575 cyproterone acetate 48 µM -0.248138183929826 0.410777954557779 no 2019 0.402013746382025 690 9880 An androgen receptor antagonist and liver toxin. SGTC_539 4859-0462 2.54 µM -0.248378242863378 0.410678014804773 no 2020 0.401920882959017 644 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2267 7931562 200 µM -0.249110841126528 0.410373060201648 no 2021 0.401637521874387 643 934880 SGTC_1997 st073024 93.8 µM -0.249764917779697 0.410100837129983 no 2022 0.401384575786796 665 686268 SGTC_1644 st010134 20.9 µM -0.250186113505718 0.409925560727794 no 2023 0.401221711832886 676 3818134 SGTC_1856 st057054 55.7 µM -0.250576984231999 0.40976291987074 no 2024 0.401070589013017 683 1266018 SGTC_1042 0350-0096 82 µM -0.25447045078711 0.408143704887962 no 2025 0.399566064864886 639 3122515 SGTC_643 k048-0106 28.4 µM -0.25450305223057 0.408130153177411 no 2026 0.399553473184882 658 6763920 SGTC_2515 chrysin 20.77 µM -0.255485238893019 0.407721931153288 no 2027 0.399174171535821 658 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1931 st074438 57.1 µM -0.255852374601967 0.407569365811177 no 2028 0.399032415184085 690 2787313 SGTC_2863 9028737 58.44 µM -0.256125021606337 0.407456074859512 no 2029 0.398927150888188 682 6460917 SGTC_554 4483-2211 187 µM -0.259205803757616 0.406176480729261 no 2030 0.397738226675728 649 747107 SGTC_1257 0669-0121 16 µM -0.259314565087649 0.406131325242005 no 2031 0.397696271181573 648 4307855 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.259991486548105 0.405850309341892 no 2032 0.397435170298684 659 688801 SGTC_2728 chlorpromazine 9.18 µM -0.260534202527088 0.405625042280694 no 2033 0.397225868085135 662 2726 A thorazine and dopamine antagonist. SGTC_875 0709-0210 25.7 µM -0.260709751753453 0.405552183121636 no 2034 0.397158172629421 682 6251364 SGTC_2514 salinomycin 42.74 µM -0.26195731032893 0.405034496437181 no 2035 0.396677177290356 685 23682228 A polyether potassium ionophore. SGTC_2183 6420625 130.508 µM -0.263345888091979 0.404458487853671 no 2036 0.396141996952089 653 2897619 SGTC_1275 0867-0008 21.1 µM -0.263652349540535 0.404331389633457 no 2037 0.396023908074812 676 3422836 SGTC_511 blebbistatin 171 µM -0.264288152736842 0.404067736302224 no 2038 0.395778944290602 672 3476986 A myosin inhibitor. SGTC_3351 9150312 21.596 µM -0.265578704696 0.403532707436815 no 2039 0.395281843987618 666 4904905 SGTC_2306 7482397 179.52 µM -0.265643401772577 0.403505890474691 no 2040 0.395256928169513 706 891448 SGTC_97 0535-0701 19.132 µM -0.26593227928661 0.403386156175578 no 2041 0.395145682316187 652 2832013 YGL099W LSG1 SGTC_400 oxethazaine 37.5 µM -0.266494062861641 0.403153333383689 no 2042 0.394929365644589 687 4621 A local anesthetic. SGTC_2677 mitomycin C 100 µM -0.267477711736673 0.402745757554692 no 2043 0.394550686335626 661 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_694 1315-0438 43.2 µM -0.267800928930504 0.402611855252809 no 2044 0.394426277825937 691 6793154 SGTC_1303 1160-0052 261 µM -0.267970903586781 0.402541442796339 no 2045 0.394360857737181 659 3562476 SGTC_3200 9114385 49.47 µM -0.268557946062377 0.402298283207549 no 2046 0.394134938917377 679 17018030 YLR208W SEC13 SGTC_1487 3970-0795 2.82 µM -0.269925857554341 0.40173182571913 no 2047 0.39360864691786 662 3765103 SGTC_2791 5663188 71.43 µM -0.27020911716073 0.401614552566491 no 2048 0.393499689509809 695 54690634 SGTC_3240 9133527 49.47 µM -0.270515871026806 0.401487562478541 no 2049 0.39338170430768 703 17617455 SGTC_292 k038-0015 474 µM -0.27068014356973 0.401419561142216 no 2050 0.393318525007384 697 46368540 SGTC_1438 4092-1045 4 µM -0.270845649463121 0.401351052274286 no 2051 0.393254874200839 666 1351342 SGTC_1803 st050068 52.4 µM -0.27121318835301 0.401198925498461 no 2052 0.393113535078665 672 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2461 5755302 26.15 µM -0.271782685010606 0.400963236658067 no 2053 0.392894559808172 713 2788904 SGTC_1821 st053465 65.6 µM -0.272079224040104 0.400840526865363 no 2054 0.392780551983305 677 675086 SGTC_1602 st001878 87.6 µM -0.273691068712622 0.400173706393581 no 2055 0.392161020960815 720 595405 YLR310C CDC25 SGTC_75 0159-0059 199.013 µM -0.274028000693212 0.400034354262474 no 2056 0.392031551761204 640 5377270 SGTC_2133 5320837 200 µM -0.274772682318448 0.39972640560988 no 2057 0.39174544344987 692 2841355 SGTC_2667 digitoxin 100 µM -0.275268531184194 0.399521391495775 no 2058 0.391554969685662 652 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1710 st031758 61.5 µM -0.275449711354788 0.399446487488361 no 2059 0.391485378209109 659 5394341 SGTC_648 0375-0473 33.3 µM -0.277023832215434 0.398795866138878 no 2060 0.390880903273558 676 1713139 SGTC_423 5-fluorouracil 457 µM -0.277115705568808 0.3987579013763 no 2061 0.390845631300897 659 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1101 ebselen 5.29 µM -0.277574326593815 0.398568400058684 no 2062 0.390669571177806 687 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_705 1124-0212 310 µM -0.278403414578217 0.398225883230937 no 2063 0.390351349316379 660 9554485 SGTC_2271 7849410 118.62 µM -0.278945083512573 0.398002148675506 no 2064 0.3901434847427 705 972430 SGTC_3021 9087658 49.47 µM -0.279069343011711 0.397950828428185 no 2065 0.390095804788244 663 25237042 SGTC_76 0433-0009 400.328 µM -0.279251821834907 0.397875466297292 no 2066 0.390025788333715 735 2841569 SGTC_219 mitoxanthrone 164.414 µM -0.280364620150187 0.397415973059771 no 2067 0.38959888900315 679 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_711 k292-0785 179 µM -0.280489998652409 0.397364211065631 no 2068 0.389550798779394 664 4146315 SGTC_366 0181-0206 4.31 µM -0.281638309928288 0.39689021971569 no 2069 0.38911043085331 687 274874 SGTC_1676 st018489 23.4 µM -0.281744818717349 0.39684626352041 no 2070 0.389069592817156 667 3696235 SGTC_3016 9080866 49.47 µM -0.282807857763569 0.396407619032005 no 2071 0.38866206525497 699 17066299 SGTC_2173 5763948 167 µM -0.283249522740982 0.396225412210997 no 2072 0.388492784185808 656 2867177 SGTC_1621 st003705 32.4 µM -0.285088427697522 0.395467024644377 no 2073 0.387788197848395 661 24207032 SGTC_1718 roemerine 11.9335 µM -0.285102561679488 0.395461197140878 no 2074 0.387782783764361 679 235224 An aporphine alkaloid with mutagenic activity. SGTC_1109 tnp00067 928.257 nM -0.285254340863911 0.395398619382975 no 2075 0.387724645454653 661 676295 SGTC_2635 hydroquinidine 100 µM -0.285909208336881 0.395128651916578 no 2076 0.387473830393547 647 442912 An experimental heart treatment. SGTC_2006 4011487 200 µM -0.286491301931184 0.394888727546699 no 2077 0.387250927234992 667 45595294 SGTC_835 0312-0010 67.2 µM -0.291163321310615 0.392964489356808 no 2078 0.385463206602526 685 1626196 SGTC_620 0109-0052 432 µM -0.292117637799039 0.392571760223441 no 2079 0.385098340766776 665 493037 SGTC_1561 5-methoxyflavone 52.9 µM -0.292985843780256 0.392214563074062 no 2080 0.384766486084333 656 94525 SGTC_1642 st009582 77.7 µM -0.294403620500231 0.391631456963488 no 2081 0.384224750340042 703 6739311 SGTC_1760 st045453 10.4495 µM -0.295009026058005 0.391382538604775 no 2082 0.383993492305157 701 3323419 YIL048W NEO1 SGTC_770 0389-1121 67.2 µM -0.295839141094658 0.391041301084274 no 2083 0.38367646495902 658 6753108 SGTC_2372 9071633 200 µM -0.295910006678435 0.391012174068429 no 2084 0.383649404448701 677 21321366 SGTC_2384 9036245 200 µM -0.296622277706816 0.390719451979747 no 2085 0.383377450395268 690 6462766 SGTC_3255 9139072 49.47 µM -0.297717713850381 0.390269381379633 no 2086 0.382959311239529 676 17646060 SGTC_1985 st071382 65.5 µM -0.298826075148697 0.389814149987501 no 2087 0.382536377190552 704 6123237 SGTC_1507 4075-3230 155 µM -0.299898414806805 0.389373857381093 no 2088 0.382127321756265 697 659771 SGTC_922 1866-0035 480 µM -0.300549909707336 0.389106428980179 no 2089 0.381878866258474 693 3156169 SGTC_1420 4'-methoxyflavone 42 µM -0.300621706186089 0.389076960866739 no 2090 0.381851488772796 693 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.301666879523393 0.388648052739237 no 2091 0.381453009490958 662 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2575 plumbagin 510 nM -0.301773626830945 0.388604254440968 no 2092 0.381412318433877 706 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1691 st019933 84.6 µM -0.301993857998765 0.388513898319731 no 2093 0.381328372552198 700 6176082 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.303487990902654 0.387901047180668 no 2094 0.380758999032125 698 4174840 SGTC_1014 4130-3005 69.3 µM -0.303553292722345 0.387874268572625 no 2095 0.380734120158883 690 743608 SGTC_3127 9126946 49.47 µM -0.304890224025667 0.387326144579968 no 2096 0.380224880802329 700 27243249 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.306037986526632 0.386855756358916 no 2097 0.379787861688881 688 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2143 5623677 140.463 µM -0.306089763340401 0.386834540546602 no 2098 0.37976815089581 651 5375313 SGTC_2136 5328288 199.296 µM -0.307109227658197 0.386416878819748 no 2099 0.379380117118043 679 262395 SGTC_1371 2421-0008 32.7 µM -0.308434035527628 0.385874318298815 no 2100 0.37887604344418 691 2827552 SGTC_2427 5545055 42.75 µM -0.309409333008223 0.385475038478412 no 2101 0.378505085885044 687 5372858 SGTC_1751 st044839 27.194 µM -0.309486166612524 0.385443588500708 no 2102 0.378475866726399 666 5291326 SGTC_2385 9074692 200 µM -0.309911522012268 0.385269493188449 no 2103 0.378314120302057 672 17046906 SGTC_1331 1472-0049 76.2 µM -0.311117980829285 0.384775823011584 no 2104 0.37785546614445 673 24051409 SGTC_3353 9151644 39.2805 µM -0.311964650836199 0.384429486074739 no 2105 0.377533694067098 691 4909158 SGTC_290 2043-6722 48.1 µM -0.312237570007881 0.384317866013787 no 2106 0.377429990803181 691 773758 YLR208W SEC13 SGTC_872 0588-0139 234 µM -0.313118802294656 0.383957520070231 no 2107 0.377095202343956 652 2047100 SGTC_1715 st032160 10.2275 µM -0.313374425013455 0.383853011775613 no 2108 0.376998106133569 712 5289825 SGTC_2197 6588183 93.1375 µM -0.314508996021688 0.383389258015334 no 2109 0.376567242514136 670 884136 SGTC_1377 2944-0135 198 µM -0.314558330758542 0.383369096319338 no 2110 0.376548510684651 692 1894137 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.316021530121235 0.382771272409469 no 2111 0.375993083134469 693 4213774 SGTC_929 2805-0021 398 µM -0.320184260152333 0.381072024228308 no 2112 0.37441432711355 722 3098024 SGTC_933 2914-0560 114 µM -0.321704304527425 0.380452103373542 no 2113 0.373838358267906 691 463887 SGTC_1115 galangin 695.678 nM -0.32278417884011 0.380011883762444 no 2114 0.373429347826918 720 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_551 k048-0028 34.9 µM -0.323127848582638 0.379871816550223 no 2115 0.373299210231835 724 6836383 SGTC_73 0327-0325 16.231 µM -0.323134961470912 0.379868917763602 no 2116 0.37329651694343 686 53298 SGTC_359 0081-0058 15.9 µM -0.32375036531952 0.379618141640068 no 2117 0.373063518309377 733 3494159 SGTC_555 4296-0685 37 µM -0.323957576218337 0.379533714905005 no 2118 0.37298507643651 700 2908540 YHR072W ERG7 SGTC_1681 tripelennamine 100 µM -0.324960641255014 0.379125103832558 no 2119 0.372605430071635 648 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_809 3998-0021 90 µM -0.325671108909979 0.378835767615137 no 2120 0.372336602638598 721 715485 SGTC_2431 5490079 200 µM -0.328140870044374 0.377830492563537 no 2121 0.371402576713371 737 5722345 SGTC_2830 7992007 71.43 µM -0.328651348298181 0.377622813795113 no 2122 0.371209615829578 683 1952075 SGTC_2691 st077356 60.2 µM -0.330176395049432 0.377002587251712 no 2123 0.370633340830275 700 2839272 SGTC_3282 9108498 15.4605 µM -0.331018628741971 0.376660192184205 no 2124 0.370315207172052 705 16459645 SGTC_2301 7769476 200 µM -0.333733869950347 0.375557021039472 no 2125 0.36929019447459 692 977820 SGTC_3086 9117350 49.47 µM -0.333838787635171 0.375514414539996 no 2126 0.369250606282336 693 2679265 SGTC_1184 1269-1718 139 µM -0.335688774661994 0.374763394742065 no 2127 0.368552785820896 671 5403821 SGTC_1540 guanosine 70.6 µM -0.336092474382875 0.374599572009584 no 2128 0.368400566627878 667 6802 Guanosine is a purine nucleoside SGTC_863 0466-0191 129 µM -0.339923262667365 0.373046155128752 no 2129 0.366957158798322 705 765160 YPR165W RHO1 SGTC_2445 5742597 35.57 µM -0.340234629290558 0.372919983606353 no 2130 0.36683992084142 690 1774255 SGTC_1304 1165-0502 251 µM -0.342069179736141 0.37217686694038 no 2131 0.366149415454982 678 767425 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.342089324894689 0.372168709428407 no 2132 0.366141835431115 686 641818 YHR062C RPP1 SGTC_1076 itraconazole 331 nM -0.343510709665447 0.37159328373365 no 2133 0.365607142654484 667 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2788 5282734 71.43 µM -0.343779843988004 0.371484361110927 no 2134 0.3655059297745 738 743706 SGTC_2467 5474540 200 µM -0.344766528601094 0.371085123395701 no 2135 0.365134949139283 671 5413519 SGTC_776 4476-4378 112 µM -0.346008057882401 0.370582966149257 no 2136 0.364668329518539 738 2892008 SGTC_2459 5811157 9.22 µM -0.347868558152271 0.369830868592517 no 2137 0.363969449599395 691 2870684 YBR192W RIM2 SGTC_699 0375-0592 111 µM -0.348014891231453 0.36977173527881 no 2138 0.363914500069168 677 762578 SGTC_1832 st054113 55 µM -0.349432678884747 0.369198965807878 no 2139 0.363382251721616 709 1251267 SGTC_33 0986-0033 35.816 µM -0.350236506850145 0.368874357653423 no 2140 0.36308060558573 688 2848082 SGTC_2756 carbadox 75.1 µM -0.350407889317595 0.368805160719278 no 2141 0.363016303224338 686 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2528 xanthyletin 44.79 µM -0.350637291006652 0.368712544753392 no 2142 0.362930238210168 694 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1707 st032323 6.317 µM -0.351007946143994 0.368562916880198 no 2143 0.362791193534623 713 3132057 YMR211W DML1 SGTC_1791 st048313 56.1 µM -0.351645707156569 0.368305509055968 no 2144 0.362551991194033 691 1204976 SGTC_1464 k208-0027 110 µM -0.352080170614223 0.368130188346274 no 2145 0.362389069523711 707 X1464 SGTC_3081 9117243 49.47 µM -0.352796685517732 0.367841110335652 no 2146 0.362120434391578 715 45595589 SGTC_1624 st003710 6.25 µM -0.353608466614704 0.367513687603322 no 2147 0.361816164188758 745 24207033 SGTC_2437 5741531 144.16 µM -0.354012080008526 0.3673509305239 no 2148 0.361664915098826 695 2262990 SGTC_3169 9102970 49.47 µM -0.35403658546608 0.36734104946646 no 2149 0.361655732679594 671 17027839 SGTC_306 1672-3436 11.6 µM -0.354814005850053 0.367027624700939 no 2150 0.361364467524423 734 6797378 SGTC_24 0417-1663 219 µM -0.355324921184272 0.366821692334341 no 2151 0.361173093800628 721 4329390 SGTC_2850 9015429 58.44 µM -0.356042471971131 0.366532537053149 no 2152 0.36090437923276 686 6457570 SGTC_122 0236-0016 402.397 µM -0.356942863897929 0.36616980846305 no 2153 0.360567289869218 703 6808838 SGTC_1082 camptothecin 424.86 nM -0.357999371567187 0.365744340121135 no 2154 0.360171891920693 680 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2866 9034245 58.44 µM -0.358026258392233 0.365733514625409 no 2155 0.36016183147698 699 6462273 SGTC_117 lucigenin 22.078 µM -0.358265121905605 0.365637345230351 no 2156 0.360072458388595 737 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_565 1418-0001 44.5 µM -0.35927909818762 0.365229199955221 no 2157 0.359693154572567 731 2862145 SGTC_2877 9040724 71.43 µM -0.359509790204457 0.365136363201435 no 2158 0.359606877590539 700 6463895 SGTC_2848 9016370 25.97 µM -0.3595490808905 0.365120552346275 no 2159 0.359592183899014 680 7894410 SGTC_714 4296-0578 26.1 µM -0.359708767281089 0.365056295752036 no 2160 0.359532467491383 695 1589775 SGTC_907 3448-6986 75.5 µM -0.359737770883114 0.36504462532878 no 2161 0.359521621656965 718 590582 SGTC_3071 9117417 49.47 µM -0.35981494269669 0.365013573666005 no 2162 0.359492763974878 704 45595590 YGL055W OLE1 SGTC_2998 9066762 71.4286 µM -0.360091032734145 0.364902490423654 no 2163 0.359389529235061 716 4945196 SGTC_1966 st070145 16.1 µM -0.360598463250108 0.364698358243032 no 2164 0.359199819142943 698 3748532 SGTC_3219 9131112 49.47 µM -0.360950211751415 0.364556877258428 no 2165 0.359068333346187 706 17612988 YMR079W SEC14 SGTC_1609 st001574 46.4 µM -0.362145383684283 0.364076290749051 no 2166 0.358621695382892 719 3960012 SGTC_2999 9069765 71.4286 µM -0.362920765116533 0.363764618996709 no 2167 0.35833203724031 710 2097066 SGTC_2772 vinpocetine 57.06 µM -0.364102472099908 0.363289794317191 no 2168 0.357890745439668 723 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_25 0118-0223 35.662 µM -0.365160177237701 0.362864973201999 no 2169 0.357495921358821 712 5333628 SGTC_443 clozapine 122 µM -0.366087670097497 0.362492589904306 no 2170 0.357149828850268 725 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2589 lobaric acid 100 µM -0.367148756944344 0.362066728863852 no 2171 0.356754030067427 700 73157 A novel microtubule depolymerizer. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.36719796137365 0.362046985089404 no 2172 0.35673567993163 696 442882 SGTC_940 3232-1287 54.8 µM -0.367303959588518 0.362004453481852 no 2173 0.356696150437287 749 1585493 YIL048W NEO1 SGTC_1501 4491-0275 38.4 µM -0.367429750685425 0.361953982224332 no 2174 0.356649241658773 715 5104718 SGTC_691 1548-0686 185 µM -0.367477393952536 0.36193486690678 no 2175 0.356631475566288 694 46495133 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.367724217895876 0.361835842310281 no 2176 0.356539440322272 731 364106 SGTC_2166 5933061 31.504 µM -0.368573086778488 0.361495350783823 no 2177 0.356222979495872 689 2877375 SGTC_1382 3002-2117 298 µM -0.368611940316227 0.361479768784607 no 2178 0.356208497150017 735 1497314 SGTC_623 k072-0108 16.9 µM -0.369362282551044 0.361178893216085 no 2179 0.355928853778594 712 5382803 SGTC_2588 indole-3-carbinol 100 µM -0.369933016880528 0.360950095103196 no 2180 0.355716199957254 728 3712 Induces cell cycle arrest. SGTC_3091 9116372 49.47 µM -0.370288972286954 0.360807423551624 no 2181 0.355583594816187 711 17169793 SGTC_3262 9137218 49.47 µM -0.370646642893073 0.360664084034221 no 2182 0.355450368310204 702 17650664 SGTC_1153 4055-0057 267 µM -0.370655293847064 0.360660617333682 no 2183 0.355447146188684 701 882706 SGTC_599 1935-0052 86.5 µM -0.371113018716288 0.360477209386521 no 2184 0.355276677401778 709 9557311 SGTC_2953 9074162 66.49 µM -0.371232741711694 0.360429242305899 no 2185 0.355232094183539 691 16451992 SGTC_475 α-linolenic acid 10 µM -0.371407267340577 0.360359322456486 no 2186 0.355167106758252 711 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_758 0868-0029 16 µM -0.371656657097685 0.360259418047429 no 2187 0.355074249781282 678 762687 SGTC_889 0919-1524 82.7 µM -0.37208856886637 0.36008641872075 no 2188 0.35491345350996 713 3905452 SGTC_2883 9059145 45.46 µM -0.373147335737957 0.359662458102535 no 2189 0.35451939494566 708 16476510 SGTC_215 1287-0124 461.5 µM -0.37326848901423 0.35961395585507 no 2190 0.354474313268915 713 5560863 SGTC_856 0433-0016 11.3 µM -0.374958578731985 0.358937585009082 no 2191 0.353845636156403 710 3911780 SGTC_1817 st052116 64.4 µM -0.375294069587024 0.358803374688928 no 2192 0.353720888084159 702 4361398 SGTC_1924 st058459 75.1 µM -0.3766787552845 0.358249627316814 no 2193 0.353206176369449 703 688683 SGTC_1141 3253-0389 52.6 µM -0.377547235449088 0.357902466839336 no 2194 0.352883484120009 742 5402031 SGTC_1506 4226-2149 212 µM -0.377810961043715 0.357797070168547 no 2195 0.352785515241503 719 991114 SGTC_698 k064-0052 127 µM -0.377847695367786 0.357782390331851 no 2196 0.352771869935978 718 5088751 SGTC_1453 4237-0541 195 µM -0.377913162172945 0.357756228890839 no 2197 0.352747552153301 712 739892 SGTC_1052 3253-3998 198 µM -0.378969853901777 0.357334052769056 no 2198 0.352355125073706 705 5450317 SGTC_1359 1582-0056 520 nM -0.379996887550579 0.356923893095966 no 2199 0.351973862774197 734 3661189 SGTC_1161 k007-0610 110 µM -0.380477130724875 0.356732158237439 no 2200 0.351795634716054 732 5843850 SGTC_2784 7567673 72.73 µM -0.38093678679008 0.356548676583287 no 2201 0.351625077453595 722 3471247 SGTC_296 1222-0039 74.9 µM -0.381336690037091 0.356389073557974 no 2202 0.351476716008981 714 5984176 SGTC_2665 lovastatin 100 µM -0.38280124076601 0.355804780256179 no 2203 0.350933570721782 718 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2225 6654152 15.4 µM -0.384257533604089 0.355224117190234 no 2204 0.350393789814703 722 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_676 falcarinol 140 µM -0.384625128717376 0.355077600202345 no 2205 0.350257586873219 756 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3261 9137475 49.47 µM -0.385958129543915 0.35454646922936 no 2206 0.349763839239248 693 17027690 SGTC_332 4112-0506 40.9 µM -0.386867539535245 0.354184279154641 no 2207 0.34942713664664 709 2790355 SGTC_1009 4106-0057 9.87 µM -0.387072337856013 0.354102732452634 no 2208 0.349351327853353 738 2928005 SGTC_2676 harmalol 100 µM -0.38814374483257 0.353676228200461 no 2209 0.348954830476877 700 5459187 A monoamine oxidase inhibitor SGTC_1193 1488-0126 41.5 µM -0.390367659822854 0.352791521714087 no 2210 0.348132349197377 689 1384710 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.391441260814382 0.352364711643556 no 2211 0.347735549359303 711 6857784 SGTC_258 haloperidol 50.781 µM -0.391930490878341 0.352170279840563 no 2212 0.347554786608401 706 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2734 clemastine 41.6 µM -0.392173730669291 0.352073624869795 no 2213 0.347464926259465 723 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1387 3342-1166 1.8 µM -0.392517730652375 0.351936947643989 no 2214 0.347337856593796 709 3418228 SGTC_1313 1220-0047 237 µM -0.393219812336692 0.351658057655829 no 2215 0.347078568890091 714 3528706 SGTC_1979 st071809 45.3 µM -0.393400122929347 0.35158644522057 no 2216 0.347011989439585 748 4976333 SGTC_601 0986-0029 62.9 µM -0.393771931923794 0.351438793611982 no 2217 0.346874714366158 721 24747981 SGTC_861 0443-0273 110 µM -0.396134925809452 0.350500933695817 no 2218 0.346002747125985 717 6149169 SGTC_746 1095-0025 46.6 µM -0.397472806024938 0.349970339371396 no 2219 0.345509418043441 738 6749286 SGTC_2170 morpholine 200 µM -0.397535928172888 0.349945312776071 no 2220 0.345486148896644 722 121171 Reacts with secondary amines. SGTC_902 1120-0002 2.07 µM -0.397902373978817 0.349800037651071 no 2221 0.3453510750229 727 3280475 SGTC_2959 9079155 11 µM -0.398790883525539 0.349447884978196 no 2222 0.345023647471631 756 16189457 SGTC_257 daunorubicin 18.5 µM -0.399732911196051 0.349074662361719 no 2223 0.344676624474213 722 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_656 4090-1979 187 µM -0.40061324445739 0.348726014398684 no 2224 0.34435244647818 728 22330961 SGTC_1865 st057639 52.2 µM -0.400899374457216 0.348612722706969 no 2225 0.344247105246486 702 688818 SGTC_107 0358-0022 2.6945 µM -0.402398359239949 0.348019428269101 no 2226 0.343695438673906 752 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2308 7584454 197.62 µM -0.402535098902739 0.347965325537371 no 2227 0.343645131354651 736 893577 SGTC_1226 3909-7979 35.4 µM -0.407954732022741 0.345823483343275 no 2228 0.341653454655635 714 6615510 SGTC_1826 st055655 41.6 µM -0.407976248868796 0.345814989643643 no 2229 0.341645556101579 703 676168 SGTC_740 k014-0057 261 µM -0.409966429205956 0.345029708939871 no 2230 0.340915287008709 736 4012779 SGTC_2602 kawain 100 µM -0.411463892173034 0.344439282986383 no 2231 0.340366206258126 730 5369129 SGTC_2870 9038528 12.99 µM -0.414190612108946 0.343365154240768 no 2232 0.339367258266478 738 6463316 SGTC_1520 flindersine 88 µM -0.415712688543754 0.342766116241298 no 2233 0.338810127652465 725 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1325 1431-0015 227 µM -0.416298741427591 0.342535570847434 no 2234 0.338595706709005 718 1103340 SGTC_573 3702-0553 84.7 µM -0.416790870018379 0.342342019317991 no 2235 0.338415690532451 714 1222756 SGTC_1661 st013063 9.66 µM -0.416794139187789 0.34234073370961 no 2236 0.338414494823324 743 721395 SGTC_1991 st073000 8.92 µM -0.417591589503534 0.342027189149567 no 2237 0.338122873525699 746 4301969 YIL048W NEO1 SGTC_2157 5649910 96.377 µM -0.417732534596266 0.341971783138982 no 2238 0.338071341108575 740 2858091 SGTC_1967 st070177 51.4 µM -0.418028235676361 0.3418555530666 no 2239 0.337963236588763 760 5729214 SGTC_1209 2323-2347 50.3 µM -0.419048367354426 0.341454688982921 no 2240 0.337590392153056 699 5412760 SGTC_2243 6634756 200 µM -0.419862172483555 0.341135029769582 no 2241 0.33729307155226 691 885676 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.420334523310144 0.340949544625141 no 2242 0.337120546555564 748 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1496 4469-0713 57.4 µM -0.420362651395824 0.340938500356437 no 2243 0.33711027392053 752 746691 SGTC_2534 helenine 20.12 µM -0.422126499837491 0.340246211938305 no 2244 0.336466343176899 725 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_830 4076-0286 57.8 µM -0.42383671736091 0.33957548672674 no 2245 0.335842449169372 718 6866659 SGTC_1879 gemcitabine 100 µM -0.423862088109604 0.33956554046402 no 2246 0.335833197220735 724 60750 A nucleoside analog which inhibits DNA replication. SGTC_1164 k060-0068 93.7 µM -0.425072407286158 0.339091180936501 no 2247 0.335391945909158 722 5963676 SGTC_2107 5363541 170.161 µM -0.425847334716451 0.338787598016503 no 2248 0.335109546395901 709 244052 SGTC_3182 9108849 49.47 µM -0.426508106003373 0.33852881920009 no 2249 0.334868821325277 719 17133045 SGTC_822 1487-0950 154 µM -0.427868962281651 0.337996105341865 no 2250 0.334373262642176 724 1958375 SGTC_871 0574-0004 149 µM -0.427944525338043 0.337966535306071 no 2251 0.334345754642283 733 9551173 SGTC_2966 9084041 48.03 µM -0.428167200379084 0.337879401859533 no 2252 0.334264697120519 723 17741380 SGTC_849 0386-0493 241 µM -0.429003487648699 0.337552237617322 no 2253 0.333960343295571 738 726119 SGTC_1564 D-Arginine 115 µM -0.429191896132464 0.337478547200095 no 2254 0.333891790002575 774 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1806 st050005 60.3 µM -0.429937320402754 0.337187057629313 no 2255 0.333620618324651 717 5194765 SGTC_99 0109-0120 622.8 µM -0.430620667451225 0.33691992847844 no 2256 0.333372105538178 754 759414 SGTC_701 4424-0219 185 µM -0.430813448867243 0.336844582609413 no 2257 0.333302009949644 745 2911779 SGTC_3036 9090181 49.47 µM -0.431688639332721 0.336502609256798 no 2258 0.332983862724816 717 25236586 SGTC_1956 st077085 54 µM -0.431925121760222 0.336410228914816 no 2259 0.332897917791859 754 24208685 SGTC_3128 9127691 49.47 µM -0.43194078918214 0.336404108885764 no 2260 0.332892224082484 749 41316314 SGTC_1433 4060-0023 7.6 µM -0.432932356253024 0.336016869884865 no 2261 0.332531956395416 717 3840627 SGTC_1098 clofazimine 15.1 µM -0.43307001399887 0.335963123828885 no 2262 0.332481953197833 734 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2064 5220758 200 µM -0.433466338952817 0.335808404423841 no 2263 0.332338007623713 730 788518 SGTC_678 1218-2179 85.9 µM -0.434219875206909 0.33551431176784 no 2264 0.332064390804395 739 6820081 YOR116C RPO31 SGTC_457 grayanotoxin iii 135 µM -0.434386811377201 0.335449172984966 no 2265 0.332003786659133 744 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3327 9140648 26.9345 µM -0.434572731788354 0.335376632340058 no 2266 0.331936295688888 746 8029710 SGTC_508 roscovitine 141 µM -0.434839506591222 0.335272555424683 no 2267 0.331839463291029 741 160355 A CDKinase inhibitor. SGTC_3162 9099653 49.47 µM -0.43488726933299 0.335253923069406 no 2268 0.33182212782854 716 25237511 SGTC_997 3996-0078 137 µM -0.435578808869745 0.334984197342959 no 2269 0.331571174275012 732 735687 SGTC_742 0kpi-0133 140 µM -0.435592483205297 0.334978864709121 no 2270 0.331566212741852 741 2728852 SGTC_3241 9133421 49.47 µM -0.436144434639756 0.334763645844028 no 2271 0.33136596989562 741 17018221 SGTC_1111 tnp00062 510.699 nM -0.436178532514009 0.334750352058776 no 2272 0.331353601084268 714 676306 SGTC_1026 k007-1105 30.6 µM -0.43648416460408 0.334631204104121 no 2273 0.331242742984909 706 7066794 SGTC_2103 5378138 10 µM -0.437012432707362 0.334425302744416 no 2274 0.33105116578781 745 244142 SGTC_2206 7254556 146.969 µM -0.438032384876639 0.33402790020139 no 2275 0.330681403802772 721 4398905 SGTC_3209 9113616 49.47 µM -0.438863089646286 0.333704371287971 no 2276 0.33038037146454 759 16649353 SGTC_2192 5915882 198.485 µM -0.439057074764496 0.333628839022586 no 2277 0.330310090574003 733 2876149 SGTC_3064 1327-0027 10 µM -0.440454126015585 0.333085066463203 no 2278 0.329804115224208 712 16000455 YPR107C YTH1 SGTC_540 1187-0821 17.3 µM -0.441184634151218 0.33280087124459 no 2279 0.329539668197497 764 847520 SGTC_1345 1488-0192 31.4 µM -0.441315069943649 0.332750136901686 no 2280 0.329492458853269 758 658348 SGTC_552 k242-0005 476 µM -0.441402243990633 0.332716231366858 no 2281 0.329460908985596 770 4088318 SGTC_2139 5578692 56.4705 µM -0.441652306577135 0.33261897944149 no 2282 0.329370413539521 753 650991 YMR113W FOL3 SGTC_3211 9128781 49.47 µM -0.44174274948047 0.332583808034556 no 2283 0.329337685510656 737 17194361 SGTC_2710 st078562 53.7235 µM -0.442341891089595 0.332350851269293 no 2284 0.32912091077546 763 17250908 SGTC_2723 salbutamol 83.58 µM -0.443071049267443 0.332067429139416 no 2285 0.328857172395367 753 9884233 β2-adrenoceptor agonist SGTC_1526 st051518 75 µM -0.443333061289432 0.331965609109152 no 2286 0.32876242277647 727 673993 SGTC_1689 st020265 53.493 µM -0.443550406699213 0.331881156307003 no 2287 0.328683833990456 748 5758320 YPR016C TIF6 SGTC_454 lyso-paf C-16 6.67 µM -0.444272439421315 0.33160066105805 no 2288 0.328422812372077 761 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2184 6075246 200 µM -0.444587595954632 0.331478258644079 no 2289 0.328308906560834 732 2267320 SGTC_2639 lactacystin 53 µM -0.444621117106895 0.331465240553448 no 2290 0.328296792078788 724 3870 A proteasome inhibitor. SGTC_2970 9090938 41.86 µM -0.445758389755431 0.331023696313823 no 2291 0.327885890907374 709 17217104 SGTC_181 1447-1644 8.07 µM -0.447526245456817 0.330337795785429 no 2292 0.327247571175074 755 534600 SGTC_1845 st056753 3.01 µM -0.447676884815088 0.330279376362415 no 2293 0.32719320313352 710 5375839 SGTC_2617 dihydrotanshinone i 20.83 µM -0.447861260836277 0.330207879160324 no 2294 0.327126664005886 725 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.448138995331288 0.330100191179063 no 2295 0.327026443280217 732 803109 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.448509808022298 0.329956435264874 no 2296 0.326892654654194 741 75037 A free radical scavenger. SGTC_896 0964-0007 44.5 µM -0.448764023330083 0.329857896093711 no 2297 0.326800947031707 720 6756758 SGTC_387 norethindrone acetate 66.7 µM -0.449455495049246 0.329589926938249 no 2298 0.326551553046613 769 541197 SGTC_2340 7987427 183.45 µM -0.452824929727137 0.328285408427967 no 2299 0.325337405377965 747 2239331 SGTC_49 0717-0965 32.132 µM -0.453311536964687 0.328097184820657 no 2300 0.325162213231589 782 5889349 YGL099W LSG1 SGTC_144 4161-2749 112.381 µM -0.453585305896876 0.327991307968673 no 2301 0.32506366578078 726 797501 YMR168C CEP3 SGTC_1938 st074717 56.4 µM -0.455240336442892 0.327351539340946 no 2302 0.324468172196744 736 17250979 SGTC_910 3454-3003 490 µM -0.4555969976532 0.327213734689395 no 2303 0.324339901259779 768 820824 SGTC_2016 5121758 140 µM -0.457575265305531 0.326449811303125 no 2304 0.323628808626196 763 2795203 SGTC_3354 9151612 71.43 µM -0.45757684037547 0.326449203367024 no 2305 0.323628242719905 749 27261949 SGTC_2714 st079313 56.9 µM -0.458001432781502 0.326285338538601 no 2306 0.323475705950446 743 2939799 SGTC_2291 7917025 104.35 µM -0.458402834422556 0.326130454653722 no 2307 0.323331527843578 723 2964612 SGTC_977 1348-1378 135 µM -0.458553306285126 0.326072401664 no 2308 0.323277487195662 749 X977 SGTC_578 3460-0051 92 µM -0.461071848995164 0.325101358694691 no 2309 0.322373528942978 781 2876744 SGTC_102 gallobenzophenone 83.616 µM -0.461876267673812 0.324791458785484 no 2310 0.322085026899065 749 70837 SGTC_127 0180-0333 59.125 µM -0.463287358804514 0.324248133047601 no 2311 0.321579202804181 735 771601 SGTC_1643 st009866 20.2 µM -0.464240781332653 0.323881239424149 no 2312 0.321237623097842 743 3156273 YOR207C RET1 SGTC_982 1491-0518 27.5 µM -0.464362317498418 0.323834482471716 no 2313 0.321194091573157 730 3091256 SGTC_504 lovastatin 124 µM -0.464542090058403 0.323765326122396 no 2314 0.321129705584807 773 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1819 st053448 58.6 µM -0.465485312155673 0.323402579638926 no 2315 0.320791976400806 774 2857616 SGTC_1036 k216-0215 33.5 µM -0.466991575672755 0.322823645443029 no 2316 0.320252952657438 734 622330 SGTC_1436 4092-1007 8.32 µM -0.468137878007178 0.322383350210471 no 2317 0.31984299670669 716 2881121 SGTC_1675 st018485 24.5 µM -0.468673416152904 0.322177735085804 no 2318 0.319651545754103 754 3323024 SGTC_473 2-arachidonoylglycerol 10 µM -0.469692019352483 0.321786801608831 no 2319 0.319287535230811 732 5282280 An endocannabinoid. SGTC_1896 st058441 89 µM -0.470273891539299 0.321563571207271 no 2320 0.319079674086794 715 688759 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.470519846703471 0.321469231928342 no 2321 0.3189918290675 756 88881 An O-methylated flavonoid and antioxidant. SGTC_3073 9114972 49.47 µM -0.470816963925191 0.321355284137941 no 2322 0.318885724633352 737 41905075 SGTC_2153 5569715 200 µM -0.472088056245251 0.320867995876283 no 2323 0.318431968644472 744 2054701 SGTC_2566 crystal violet carbinol 226 nM -0.472265259286285 0.320800087473626 no 2324 0.318368732106452 781 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_755 1995-0008 37.3 µM -0.472351684093133 0.320766969615554 no 2325 0.318337892537514 738 689533 SGTC_2436 5633522 8.09 µM -0.472547848969109 0.320691804818768 no 2326 0.318267898323326 763 5724242 SGTC_958 1222-0007 33 µM -0.47345788955794 0.320343199365572 no 2327 0.317943268741378 771 7312461 SGTC_3014 9081533 49.47 µM -0.473976298787798 0.32014468533498 no 2328 0.317758404363286 784 21367265 SGTC_688 0527-0193 473 µM -0.474578506525088 0.319914147036609 no 2329 0.317543714521103 744 4007154 SGTC_463 ikarugamyin 104 µM -0.474735485062158 0.319854063639629 no 2330 0.317487761024742 759 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1776 st049249 45.9 µM -0.475516132953575 0.319555341560504 no 2331 0.317209568506726 738 1822314 SGTC_650 1328-0195 38 µM -0.475777998171643 0.319455162638503 no 2332 0.317116273057063 778 2780821 SGTC_2768 sulfasalazine 50.2 µM -0.479291354894352 0.318112372753378 no 2333 0.315865685735951 791 5384001 An antioxidant and salicylic acid derivative. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.480267826814512 0.317739592553033 no 2334 0.3155184814932 782 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2036 5160441 105 µM -0.480381223349962 0.317696313988349 no 2335 0.315478171618007 760 134534 YIL048W NEO1 SGTC_1004 4084-0029 199 µM -0.480949648300436 0.317479408258453 no 2336 0.315276142645154 724 716894 YLR208W SEC13 SGTC_2405 ticlatone 3.52 µM -0.480953954773606 0.317477765186968 no 2337 0.315274612253894 740 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1048 3161-0300 24.5 µM -0.484295395858464 0.316203973471121 no 2338 0.314088121507489 727 2165101 SGTC_354 2783-3500 4.88 µM -0.484588213391801 0.316092452005558 no 2339 0.313984238099323 763 6740761 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.484817687483485 0.316005066995347 no 2340 0.31390283746034 770 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2813 7971799 71.43 µM -0.485239637260975 0.31584441300444 no 2341 0.313753184149831 757 2234054 SGTC_1765 st044815 90.4 µM -0.486447826394172 0.315384597145982 no 2342 0.313324844143336 750 645695 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.487260805256521 0.315075352262325 no 2343 0.313036759887307 745 2333 A French combination drug. SGTC_790 1575-0012 79.1 µM -0.487301674864876 0.315059809499201 no 2344 0.313022280491239 761 378741 YLR208W SEC13 SGTC_1078 idebenone 36.1 µM -0.487928980290351 0.31482128556053 no 2345 0.312800073210237 761 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_962 1254-0300 21.5 µM -0.488197605466413 0.314719168280328 no 2346 0.312704940241304 740 7340576 SGTC_3294 9122953 26.2835 µM -0.488243227544543 0.314701826553147 no 2347 0.31268878452968 757 16459826 SGTC_43 0570-0105 72.5 µM -0.488290048093466 0.314684029691781 no 2348 0.312672204789183 770 1114046 YDL195W SEC31 SGTC_68 0986-0284 82.829 µM -0.489183366609629 0.314344554749811 no 2349 0.312355942197374 717 423278 YIL048W NEO1 SGTC_2580 diallyl disulphide 81.36 µM -0.492869705218024 0.312945351396606 no 2350 0.311052327130231 735 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1219 1469-0211 33.1 µM -0.492925567244953 0.312924168795483 no 2351 0.311032590579722 777 6822282 SGTC_2212 7123476 200 µM -0.493316709731942 0.312775866826247 no 2352 0.31089441169058 746 1085715 SGTC_1131 3454-3128 32.3 µM -0.494419489772999 0.312357910138545 no 2353 0.310504976227815 724 710982 SGTC_1379 2144-0755 36.5 µM -0.495407214792755 0.311983764447135 no 2354 0.310156351466294 769 5392327 SGTC_2967 9089538 49.85 µM -0.497810382309029 0.311074266003814 no 2355 0.309308848719145 789 728216 SGTC_207 4185-0010 4.486 µM -0.497882031118459 0.311047167591346 no 2356 0.309283596536799 747 3761753 SGTC_3269 9137823 49.47 µM -0.499088772622784 0.310590917942411 no 2357 0.308858423340061 743 17682936 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.501137237782864 0.309817092975972 no 2358 0.30813727063143 737 1609 A potent and irreversible inhibitor of serine proteases. SGTC_981 1488-1094 54.9 µM -0.501602630166647 0.30964140433237 no 2359 0.307973534456909 750 3449522 SGTC_1636 st007707 68.9 µM -0.509723653835358 0.306582693681915 no 2360 0.305122539535218 787 403051 SGTC_1895 st058434 18.3 µM -0.51061046321108 0.306249494138754 no 2361 0.304811923890443 795 5393175 SGTC_265 mycophenolic acid 32.932 µM -0.510626107896709 0.306243617421836 no 2362 0.304806445412948 765 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2317 5986382 200 µM -0.511139438229424 0.306050819407886 no 2363 0.304626710975113 789 877883 SGTC_1245 0418-0076 17.2 µM -0.511989339125907 0.30573172940455 no 2364 0.304329235396474 782 6790114 SGTC_320 4092-0846 5.34 µM -0.51205851477751 0.305705764322377 no 2365 0.304305028776194 765 1359356 SGTC_2744 captopril 92.04 µM -0.51319559909504 0.305279099775613 no 2366 0.303907252062802 744 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_413 propylparaben 100 µM -0.513935743615895 0.305001519726891 no 2367 0.303648458143612 768 7175 A pharmaceutical preservative. SGTC_1055 3448-0672 86 µM -0.514100262892525 0.304939834482406 no 2368 0.303590946814373 763 748378 SGTC_151 3013-0144 2.285 µM -0.514891251084779 0.30464333692135 no 2369 0.303314507437341 766 906558 YHR107C CDC12 SGTC_610 4215-0184 155 µM -0.51527711216406 0.304498745567282 no 2370 0.303179695195175 759 5605015 SGTC_493 zm226600 134 µM -0.515570995128976 0.304388641098068 no 2371 0.303077036269091 788 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1662 st014054 52 µM -0.516854311031489 0.30390804930597 no 2372 0.302628931878078 768 2838777 SGTC_2199 6590217 200 µM -0.516854965258635 0.303907804389328 no 2373 0.302628703512737 740 703109 SGTC_1434 4073-0095 163 µM -0.518285232944366 0.303372579613302 no 2374 0.302129637239414 775 24133745 SGTC_1170 0310-0127 64.8 µM -0.518814078318987 0.30317478551502 no 2375 0.301945199734891 788 774975 SGTC_1354 1498-1681 81 µM -0.519794540972803 0.302808234150646 no 2376 0.301603392304131 773 5754243 SGTC_3324 9138759 60.749 µM -0.52064332752405 0.302491070985573 no 2377 0.301307630232845 764 45595710 SGTC_2229 7354935 190 µM -0.523926322490187 0.301265730124436 no 2378 0.300164892931044 779 318112 SGTC_2696 st077691 74.316 µM -0.524298821014448 0.30112684057088 no 2379 0.3000353583935 786 757133 SGTC_596 1155-0152 116 µM -0.525213589298677 0.300785883165456 no 2380 0.299717359565885 763 280313 SGTC_3189 9110682 49.47 µM -0.526795076677887 0.300196833844494 no 2381 0.299167951104487 776 17122418 SGTC_3165 9101544 49.47 µM -0.527414138941705 0.299966396703967 no 2382 0.298953013520949 775 5002184 SGTC_211 3455-0679 143.504 µM -0.529300643782015 0.299264666206347 no 2383 0.298298454539193 751 748649 SGTC_2355 9061122 103.12 µM -0.53059725258023 0.298782793902968 no 2384 0.297848949982593 787 5302957 SGTC_322 k048-0136 19.3 µM -0.530788258232535 0.298711838282473 no 2385 0.297782758811543 763 6823282 SGTC_1844 rapamycin 4 nM -0.531744845601303 0.298356596302633 no 2386 0.297451363654355 784 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1922 5578187 25 µM -0.532762998747372 0.297978702426319 no 2387 0.297098825117396 749 1350412 SGTC_2078 5212016 200 µM -0.533189502013064 0.297820467947237 no 2388 0.296951203901128 784 1899708 SGTC_60 0986-0278 202 µM -0.533649567279313 0.297649824803897 no 2389 0.29679200384546 814 3110598 SGTC_1698 5-fluorocytosine 1.055 µM -0.534152615001985 0.297463290090009 no 2390 0.296617974956597 776 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1281 0884-0031 11.8 µM -0.534533051812732 0.297322256089535 no 2391 0.296486394246913 776 1548255 SGTC_113 0099-0221 2.5 µM -0.535806386379473 0.29685043303875 no 2392 0.296046183982671 781 89219 SGTC_381 3461-2219 42.7 µM -0.536258657722701 0.296682930335493 no 2393 0.295889899438799 800 2883159 SGTC_2051 5263410 176 µM -0.537675460497221 0.296158485246747 no 2394 0.295400561838338 788 227584 SGTC_880 0833-0487 87.2 µM -0.53787447034139 0.296084853650847 no 2395 0.295331857331377 764 76075 SGTC_385 1494-0393 12.4 µM -0.538190494313782 0.295967945297152 no 2396 0.295222770949732 774 3090647 SGTC_2307 7538926 6.34 µM -0.5392533201264 0.295574924322994 no 2397 0.294856036767073 774 96582 SGTC_580 1123-0028 41 µM -0.542815016382151 0.294259601999563 no 2398 0.293628586560373 783 1677248 YPR107C YTH1 SGTC_2044 5102272 200 µM -0.543191660951 0.29412066665584 no 2399 0.293498923777253 768 592666 SGTC_581 0958-0271 211 µM -0.544373473244909 0.293684920749463 no 2400 0.293092248075099 771 4591145 SGTC_1333 1482-0047 286 µM -0.546153719216621 0.293029091078425 no 2401 0.292480138078473 791 3811116 SGTC_42 0133-0086 60.653 µM -0.547420803079612 0.292562720873424 no 2402 0.292044833209528 803 162923 Model of phenazepam hydroxylation. SGTC_2329 6138490 200 µM -0.548852671045535 0.292036114767798 no 2403 0.291553280288402 774 720019 SGTC_488 nitrendipine 139 µM -0.549316202614794 0.291865733760346 no 2404 0.291394234984087 776 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1217 1183-1422 255 µM -0.551392689857331 0.29110304507834 no 2405 0.29068225538885 762 2849664 SGTC_970 1315-0089 19.5 µM -0.551630460261215 0.291015772019183 no 2406 0.290600781346158 773 6811083 YLR033W RSC58 SGTC_1321 1326-2144 215 µM -0.552009905483611 0.290876522880476 no 2407 0.290470783361148 793 3513030 SGTC_899 1083-0020 478 µM -0.55340757770066 0.290363872735803 no 2408 0.289992175613534 800 767123 SGTC_2894 9048625 32.47 µM -0.554767967624312 0.289865303965706 no 2409 0.289526689888831 805 4092861 SGTC_2766 oltipraz 83.91 µM -0.555464494696492 0.289610189552432 no 2410 0.289288494547456 790 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2792 7535235 81.82 µM -0.555657678111636 0.289539451648454 no 2411 0.289222446829474 750 1281891 SGTC_3323 9138564 53.9225 µM -0.557460048738515 0.288879869511076 no 2412 0.288606573947718 761 43912313 YNL103W MET4 SGTC_3108 9121785 49.47 µM -0.558945936726568 0.288336637372335 no 2413 0.288099308740902 767 17140271 SGTC_3168 9103419 49.47 µM -0.561457205595947 0.287419628371674 no 2414 0.287242947912044 789 16649256 SGTC_2347 9049783 174.81 µM -0.561517525716396 0.28739761899405 no 2415 0.287222393139464 815 6467988 YPL169C MEX67 SGTC_26 0302-0163 425.158 µM -0.561831200092111 0.287283179526976 no 2416 0.287115516224292 810 3100915 SGTC_646 4092-0839 27.3 µM -0.562116184391811 0.287179225909621 no 2417 0.287018431082972 788 877796 SGTC_3352 9151559 45.5865 µM -0.56363107128074 0.286626940293989 no 2418 0.286502618186806 760 17159339 SGTC_531 3788-1495 174 µM -0.564469240467861 0.286321583734273 no 2419 0.286217414067584 755 2896655 SGTC_2214 7179297 48.276 µM -0.566039297175362 0.285750006454508 no 2420 0.285683533466861 762 769744 SGTC_2769 toremifene 3.73 µM -0.566122553963193 0.28571971207934 no 2421 0.285655236140636 773 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1700 st030840 7.9285 µM -0.567012519400398 0.285395978758403 no 2422 0.28535283794274 777 5499307 SGTC_2259 7964009 200 µM -0.568122328614967 0.284992520097427 no 2423 0.284975953567898 774 313134 SGTC_1287 0971-0001 34.6 µM -0.56824400061563 0.284948304159156 no 2424 0.284934648949591 768 4665869 SGTC_1813 st051246 8.6015 µM -0.569165447680074 0.284613554031714 no 2425 0.284621933321319 781 5291959 SGTC_733 4069-0007 56.1 µM -0.569623682773107 0.28444715292368 no 2426 0.284466481052525 790 5717425 YNL287W SEC21 SGTC_2545 solidagenone 89.61 µM -0.571509541752036 0.283762821597171 no 2427 0.283827147106462 745 6708572 An anti ulcer agent SGTC_147 4466-0538 29.23 µM -0.571538284191381 0.283752397782751 no 2428 0.283817408320858 792 6742687 YHR072W ERG7 SGTC_3096 9117468 49.47 µM -0.571755268346213 0.283673711612474 no 2429 0.283743892856852 793 41316311 SGTC_2881 9058953 51.95 µM -0.572026415944848 0.283575398544156 no 2430 0.283652039329521 752 17122249 SGTC_444 curcumin 90.4 µM -0.572582372250069 0.283373870212287 no 2431 0.283463749014265 776 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2705 st078069 42.8 µM -0.573122658650286 0.28317808787214 no 2432 0.283280823174023 786 1530061 SGTC_3229 9132204 49.47 µM -0.573896569773995 0.282897760584989 no 2433 0.283018897218582 787 17682924 SGTC_1768 st044301 37.178 µM -0.574420157139246 0.282708181565346 no 2434 0.282841757914954 829 3931349 SGTC_1914 st062367 72.6 µM -0.575358574988254 0.282368554740979 no 2435 0.282524407088982 790 978205 SGTC_689 0833-0039 98 µM -0.575843009460747 0.282193307831092 no 2436 0.282360649781602 837 5374726 SGTC_3286 9117135 37.221 µM -0.575980174564297 0.282143697090938 no 2437 0.282314291047095 783 3438150 SGTC_119 0121-0043 24.815 µM -0.577041156861307 0.281760096232961 no 2438 0.281955826553012 805 1092378 SGTC_1469 k284-2957 126 µM -0.578921763981058 0.281080776282348 no 2439 0.281320982092955 781 23884841 SGTC_1796 st049173 110.4 µM -0.579630582068976 0.280824939825463 no 2440 0.28108188255821 822 94134 SGTC_1156 4092-0367 4.88 µM -0.580284915021074 0.280588868882627 no 2441 0.280861249206249 810 1357585 SGTC_138 0850-0259 40.9225 µM -0.580741896842433 0.280424055461353 no 2442 0.280707209998515 780 6813004 SGTC_1888 azatryptophan 97.5 µM -0.581223551819776 0.280250394256469 no 2443 0.280544898220629 773 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_134 0269-0018 6.916 µM -0.581881686436551 0.28001318739061 no 2444 0.280323188441451 776 4378915 SGTC_505 gw-5074 63.9 µM -0.581924258110803 0.279997846931448 no 2445 0.280308849987142 792 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2743 auranofin 4.32 µM -0.582532870906849 0.279778581354306 no 2446 0.280103903548814 755 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_543 3844-1095 191 µM -0.582792086745147 0.279685218691829 no 2447 0.280016636342385 795 4230703 SGTC_1513 0337-0559 19 µM -0.583033375332967 0.279598326538508 no 2448 0.279935416342883 785 775073 SGTC_9 0092-0002 10.449 µM -0.583381315599714 0.279473050366768 no 2449 0.279818316506036 789 759368 SGTC_1103 duloxetine 36.1 µM -0.585529316603691 0.278700265047901 no 2450 0.279095930048824 790 60835 A selective serotonin reuptake inhibitor. SGTC_2712 st079126 47.7 µM -0.587757648363823 0.277899680192035 no 2451 0.278347487430869 789 3152970 SGTC_337 1315-0038 354 µM -0.589881269404814 0.277137761460795 no 2452 0.277635126210111 797 1626437 SGTC_828 2074-0507 139 µM -0.590062631400502 0.277072739298082 no 2453 0.27757433026923 794 X828 SGTC_893 0958-0369 48.9 µM -0.590776400244148 0.276816910406449 no 2454 0.277335124769938 805 6819948 SGTC_2344 7990960 76.95 µM -0.590863162190007 0.276785821094978 no 2455 0.277306055093809 809 140813 SGTC_786 4544-0069 423 µM -0.591130924718883 0.27668988483216 no 2456 0.277216350389413 772 748821 YLR208W SEC13 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.5911441642628 0.276685141677223 no 2457 0.277211915300023 789 77254 SGTC_1941 st076221 61.8 µM -0.591334404010991 0.276616991418012 no 2458 0.277148191085154 777 2828568 SGTC_3315 9136395 68.55 µM -0.591717475281418 0.276479787406897 no 2459 0.277019896245393 824 16876844 SGTC_2519 cryptotanshinone 88.04 µM -0.592584618167069 0.276169327574527 no 2460 0.276729587852052 794 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1059 3448-6867 171 µM -0.593040128327365 0.276006311601702 no 2461 0.276577148591002 799 3934407 SGTC_2466 5983409 37.09 µM -0.593053275645855 0.276001607198894 no 2462 0.276572749371708 786 2879657 SGTC_2525 harmine 47.85 µM -0.593176655352184 0.275957461116158 no 2463 0.276531467005981 777 5280953 A monoamine oxidase inhibitor SGTC_1882 5615643 20 µM -0.593447258445965 0.275860649668685 no 2464 0.276440934852524 794 2253075 SGTC_2378 9074213 121.43 µM -0.59360784310455 0.275803206504011 no 2465 0.276387217007243 791 657714 SGTC_1614 st002383 48.6 µM -0.593810719075358 0.27573064360643 no 2466 0.276319359439154 777 1947235 SGTC_1712 st032288 53.4 µM -0.594558601505542 0.27546322866131 no 2467 0.276069279772634 787 2883011 SGTC_1185 1319-0113 81.3 µM -0.59468060137169 0.275419618152604 no 2468 0.276028495555208 807 4672763 SGTC_1373 2887-0003 58.5 µM -0.596830762153809 0.274651571961551 no 2469 0.275310188718409 805 776948 SGTC_245 methotrexate 289.6 µM -0.598520751079463 0.274048643362514 no 2470 0.274746258515402 774 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2666 tannic acid 100 µM -0.599280053896723 0.273777963927285 no 2471 0.274493073306504 807 16134267 A thiamine antagonist. SGTC_2570 licareol 100 µM -0.600322001918589 0.273406741289615 no 2472 0.274145829154949 798 443158 SGTC_1774 st048371 48.465 µM -0.600482033162533 0.273349747844364 no 2473 0.274092515672905 806 4242727 SGTC_818 4072-2707 53.5 µM -0.600627555107046 0.273297926841696 no 2474 0.274044040327212 797 882871 SGTC_2611 pyromycin 23.93 µM -0.601001070092172 0.273164938794645 no 2475 0.273919636783223 798 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2790 5423970 71.43 µM -0.603920043254298 0.272126759531164 no 2476 0.272948401201915 798 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1080 nisoldipine 24.4 µM -0.60457445936073 0.271894275486215 no 2477 0.272730890624179 812 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2356 9061756 188.97 µM -0.604915054794677 0.271773316648375 no 2478 0.272617719763815 787 20104043 SGTC_858 0438-0351 2.77 µM -0.605519147231941 0.271558845551735 no 2479 0.272417053165597 798 2799119 SGTC_1505 k297-0037 20.6 µM -0.605696321661192 0.271495959256905 no 2480 0.272358213522783 780 4089396 SGTC_3304 9125678 46.087 µM -0.606286713002512 0.271286458117243 no 2481 0.272162190090321 805 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1688 st021091 57.6 µM -0.608678910995077 0.270438409085243 no 2482 0.271368644083921 821 3656366 SGTC_3252 9135871 49.47 µM -0.609012543654379 0.27032023959139 no 2483 0.271258062289369 816 17682838 SGTC_1429 4049-0205 9.46 µM -0.609839562350227 0.270027428830439 no 2484 0.270984045688014 795 22774478 SGTC_2053 5265679 138 µM -0.61016523757198 0.269912165200666 no 2485 0.270876177431811 817 764595 SGTC_2274 7947094 46.08 µM -0.610859607242423 0.26966649474902 no 2486 0.270646263913638 791 2971028 SGTC_2348 9022543 33.42 µM -0.61159144145953 0.269407690503496 no 2487 0.270404051001651 805 3162678 YDL140C RPO21 SGTC_2650 prasterone 100 µM -0.611640658356041 0.269390290017966 no 2488 0.270387765726085 783 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3174 9107204 49.47 µM -0.612002796647384 0.26926227444395 no 2489 0.270267953622831 814 3938802 SGTC_86 0417-1630 471.922 µM -0.614159072717613 0.268500664970109 no 2490 0.269555107770683 806 3634867 SGTC_2947 9072639 7.68 µM -0.614361008352684 0.268429395607121 no 2491 0.269488397910195 814 16488146 SGTC_1165 k072-0275 30.3 µM -0.614898132739978 0.268239874025738 no 2492 0.269310998027931 800 6153523 YGL055W OLE1 SGTC_91 0417-1751 58.384 µM -0.615353563513639 0.26807923037584 no 2493 0.269160625567898 815 6795624 SGTC_3228 9131799 49.47 µM -0.619422855419985 0.266646025892669 no 2494 0.267818914192717 810 17015818 SGTC_1729 st035615 45.989 µM -0.621461516702821 0.265929468773119 no 2495 0.267148003692975 811 17385451 SGTC_2603 homopterocarpin 100 µM -0.623091519570211 0.26535725132713 no 2496 0.266612191121743 810 101795 A weak amylase inhibitor. SGTC_3119 9125183 49.47 µM -0.623175159079036 0.265327906288979 no 2497 0.266584711907054 782 22695334 SGTC_2279 7948423 32.93 µM -0.623750504994283 0.265126090021154 no 2498 0.26639572458031 770 1247112 SGTC_1395 3486-0190 4.35 µM -0.624905397926821 0.264721219307534 no 2499 0.266016574674413 816 6748079 SGTC_2759 disulfiram 3.38 µM -0.624938530390026 0.264709608703805 no 2500 0.266005701362926 800 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1730 st033808 45.1 µM -0.625931786009802 0.264361662586886 no 2501 0.265679842312942 816 1045166 SGTC_2433 5607874 27.82 µM -0.626981478123473 0.263994199484338 no 2502 0.265335688166183 802 2252428 SGTC_2272 7805186 180 µM -0.627147958677846 0.26393594397638 no 2503 0.265281126317437 832 2956062 YPR165W RHO1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.627428138633109 0.263837917137574 no 2504 0.265189313821386 827 688751 SGTC_631 k072-0230 41.5 µM -0.627763259499681 0.263720692452278 no 2505 0.265079518870245 805 5773147 SGTC_1581 himbacine 57.9 µM -0.627763889092049 0.263720472246986 no 2506 0.265079312619942 822 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2164 5685496 200 µM -0.627841252444435 0.263693414469543 no 2507 0.265053969517049 809 759046 SGTC_291 SEC14.278 35.5 µM -0.628556999468561 0.263443149629303 no 2508 0.264819559645903 802 1068044 SGTC_576 1073-0113 22.7 µM -0.629665525841757 0.263055786801124 no 2509 0.264456721169729 840 5439563 SGTC_2622 2-methoxyxanthone 59.94 µM -0.633793745837263 0.261615788835139 no 2510 0.263107717639785 802 71034 A hepatoprotective. SGTC_674 0498-0004 451 µM -0.634765481538053 0.261277419004008 no 2511 0.262790689675997 804 4231473 SGTC_1343 1487-0095 224 µM -0.635700217234961 0.260952145302274 no 2512 0.262485917397204 830 4560101 YGL055W OLE1 SGTC_727 3032-0951 202 µM -0.636864370907686 0.260547329035108 no 2513 0.262106596138194 810 3652836 SGTC_950 1165-0508 94.1 µM -0.637566807170922 0.26030322428727 no 2514 0.261877854243676 807 6148369 SGTC_420 mitomycin C 81.9 mM -0.641065674764538 0.259089084833328 no 2515 0.260740007211354 810 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2762 leflunomide 42.06 µM -0.642944544675615 0.258438310068976 no 2516 0.260130042037294 828 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2124 5246320 200 µM -0.643266635890665 0.258326834032346 no 2517 0.260025550733975 810 579342 SGTC_869 0564-0080 44.1 µM -0.643524576455049 0.258237578560186 no 2518 0.259941886489468 790 6843321 SGTC_2359 9039622 200 µM -0.644746423432136 0.257814998740081 no 2519 0.259545763371135 817 6463596 SGTC_647 0140-0236 81 µM -0.64551534875413 0.257549247478988 no 2520 0.259296637474774 806 990837 SGTC_1969 st069479 40.1 µM -0.645873888467858 0.257425379833494 no 2521 0.259180515618505 819 3895485 SGTC_1138 3761-0006 1.03 µM -0.646058160148063 0.257361730034002 no 2522 0.259120845187469 809 12061087 SGTC_2825 7998094 58.44 µM -0.64653175034431 0.257198183438715 no 2523 0.258967520891518 804 2987815 SGTC_1703 st026983 48.3 µM -0.647084219581003 0.257007465567084 no 2524 0.258788718913335 807 1104023 SGTC_1121 fusaric acid 630.51 nM -0.649021733229564 0.256339198453031 no 2525 0.258162164357068 790 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1238 0333-0287 48.8 µM -0.649563040014042 0.256152658515309 no 2526 0.2579872568426 807 7226 SGTC_1220 1838-0075 193 µM -0.65031493352623 0.255893665706656 no 2527 0.257744406393588 801 5529645 SGTC_838 0109-0203 71.4 µM -0.652326619243343 0.25520140480866 no 2528 0.257095245687182 793 759422 SGTC_2232 chlorophetanol 41.5365 µM -0.652394970098697 0.255177901138793 no 2529 0.257073204160714 820 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1278 0874-0585 172 µM -0.652951813601331 0.254986462677951 no 2530 0.256893671989827 807 766306 SGTC_2424 5537928 59.2 µM -0.656232625786958 0.253860072434723 no 2531 0.255837229911193 826 5382802 SGTC_881 0833-0569 170 µM -0.656243005810649 0.253856512845338 no 2532 0.255833891080708 811 5418700 SGTC_2060 5238662 140 µM -0.656638897933737 0.25372077034252 no 2533 0.25570656570047 827 790130 SGTC_1299 1079-1439 3.74 µM -0.657193580581682 0.253530646272093 no 2534 0.255528226361967 823 323161 SGTC_2075 5212009 200 µM -0.658136277137496 0.253207697609586 no 2535 0.255225283470324 828 780898 SGTC_1723 st034307 2.5525 µM -0.658986332662993 0.252916671471611 no 2536 0.254952272596553 833 867466 SGTC_2782 7736369 71.43 µM -0.659731303729526 0.252661767008804 no 2537 0.25471313722281 828 2950836 YOL077C BRX1 SGTC_1846 st056244 14.8 µM -0.661269692489964 0.252135809766831 no 2538 0.25421968707042 827 5393182 SGTC_692 k241-0027 77.8 µM -0.662334750929767 0.251772017257781 no 2539 0.253878355176601 816 3600480 SGTC_340 k038-0059 454 µM -0.66361826427518 0.251333975525988 no 2540 0.253467332288631 824 23733424 SGTC_1868 st057644 42.7 µM -0.664417144380538 0.251061534614759 no 2541 0.253211681456948 823 688665 SGTC_2537 larixol 68.93 µM -0.666049476878924 0.250505348798696 no 2542 0.252689738148411 825 6708759 SGTC_2326 6164455 177.58 µM -0.666612758023722 0.250313573245111 no 2543 0.252509758864841 824 2888790 SGTC_2975 9084847 53.72 µM -0.667427024856662 0.250036484369235 no 2544 0.252249704215019 801 27211724 SGTC_3281 9140613 49.47 µM -0.667643411347888 0.249962877054569 no 2545 0.252180620021823 804 16013766 SGTC_460 trequinsin 123 µM -0.668030207850627 0.249831330712728 no 2546 0.252057155087489 843 5537 A vasodilator. SGTC_2502 avocadyne acetate 18.59 µM -0.669943194374571 0.249181280299364 no 2547 0.251447001502359 803 3952079 SGTC_62 0180-0423 3.232 µM -0.670578692518723 0.24896553141067 no 2548 0.251244480061506 845 30102 YGL099W LSG1 SGTC_2909 7941780 10.49 µM -0.671762952740322 0.24856374553669 no 2549 0.25086730860677 814 1243215 SGTC_2322 7413319 38.22 µM -0.672635693235728 0.248267870701095 no 2550 0.250589544076873 818 1840400 SGTC_1239 0337-0584 35.4 µM -0.673084076366891 0.248115933751933 no 2551 0.250446901887789 835 914301 YML130C ERO1 SGTC_1250 0485-0349 40.2 µM -0.673369951603849 0.24801908934377 no 2552 0.250355980102012 825 6842794 YDL195W SEC31 SGTC_550 4123-0385 25.7 µM -0.674585525251952 0.247607521340059 no 2553 0.249969565914064 824 5731123 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.67599760373107 0.247129879302113 no 2554 0.249521083231129 842 91467 include heat shock SGTC_3006 9075424 71.4286 µM -0.676022183149757 0.247121569566753 no 2555 0.249513280481151 822 7465181 SGTC_1917 st066507 28.5 µM -0.676031914713332 0.247118279590539 no 2556 0.249510191226771 818 3156428 SGTC_203 k066-0004 30.888 µM -0.676394943525621 0.246995566190795 no 2557 0.249394963388956 834 6795412 SGTC_2393 9031399 185.94 µM -0.677621886530915 0.246581068232188 no 2558 0.249005732688164 842 1526623 YDL150W RPC53 SGTC_3333 9141820 12.094 µM -0.677799336948757 0.246521151043087 no 2559 0.248949465764372 820 1939433 SGTC_1686 st019653 115.5 µM -0.67797645940311 0.246461352372422 no 2560 0.248893309581382 849 97252 SGTC_707 0865-0008 204 µM -0.67846739517223 0.24629564718954 no 2561 0.248737695007035 844 723043 SGTC_284 0988-0104 32.6 µM -0.678572740658529 0.246260097791021 no 2562 0.248704309829344 836 4666532 SGTC_94 0334-0113 514.748 µM -0.678939847956361 0.246136236967397 no 2563 0.248587988018641 834 6795178 SGTC_820 1582-0060 59.9 µM -0.679899772055638 0.245812519629064 no 2564 0.24828396299121 828 3848840 SGTC_3060 1327-0027 12.5 µM -0.680398755557734 0.245644336634422 no 2565 0.248126004389537 812 16000455 YPR107C YTH1 SGTC_719 2810-4230 27.3 µM -0.682564468740025 0.244915097106796 no 2566 0.247441046220758 826 721079 SGTC_3310 9130229 44.1445 µM -0.68333915424405 0.244654527961567 no 2567 0.2471962791539 835 7761258 SGTC_1786 berberine 21.6 µM -0.683375978195299 0.244642145768619 no 2568 0.247184647604667 834 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3309 9129340 25.759 µM -0.684590573736352 0.244233922626652 no 2569 0.246801158471097 822 17158987 SGTC_3166 9102297 49.47 µM -0.686800798597417 0.243492013589964 no 2570 0.246104133240911 830 25237072 SGTC_2114 5491910 81.25 µM -0.686957889886213 0.243439328933214 no 2571 0.246054632534365 834 2849228 SGTC_2048 5246248 200 µM -0.687283666541588 0.243330090876096 no 2572 0.245951994761363 819 677046 SGTC_2074 5212007 75.395 µM -0.687296874162482 0.24332566271108 no 2573 0.24594783411053 821 758611 SGTC_712 r015-0009 80.6 µM -0.687647184265805 0.243208228921678 no 2574 0.245837493577312 834 6813872 YLR060W FRS1 SGTC_1816 st051957 91.6 µM -0.687853001247233 0.24313924757828 no 2575 0.245772677822408 844 674121 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.690026096892443 0.242411561705394 no 2576 0.245088888059055 819 66535 A nucleotide analog. SGTC_2256 7954252 200 µM -0.691172519821854 0.24202814485743 no 2577 0.244728565505158 847 2972920 SGTC_3244 9134489 49.47 µM -0.691942799718894 0.24177071248145 no 2578 0.244486625590946 856 16584271 SGTC_1594 piperine 70.1 µM -0.693098784947364 0.241384653974031 no 2579 0.244123780068778 822 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1053 3366-3204 134 µM -0.693479502145322 0.241257581138509 no 2580 0.244004342549631 849 3632071 YPR165W RHO1 SGTC_269 exalamide 29 µM -0.693975023823201 0.241092244219445 no 2581 0.243848936120885 828 3316 A derivative of salicylamide. SGTC_350 k064-0020 19.8 µM -0.694826243145445 0.240808368260614 no 2582 0.243582099877495 831 2790705 SGTC_2383 9036125 200 µM -0.694867109341174 0.240794744234036 no 2583 0.243569293302301 831 79580 SGTC_1254 0550-0035 264 µM -0.695069206317311 0.240727375041953 no 2584 0.243505965860321 841 15121435 SGTC_2293 7624732 200 µM -0.695533350950711 0.240572690888684 no 2585 0.243360559000682 824 894453 SGTC_205 1486-1330 71.903 µM -0.696434605113755 0.240272487114692 no 2586 0.243078348878307 832 4118834 SGTC_986 1493-0483 84 µM -0.696899764642717 0.240117624433976 no 2587 0.242932762540342 837 40079 SGTC_393 acivicin 6.25 µM -0.697743597366731 0.239836831363564 no 2588 0.242668778943297 829 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.698451177281622 0.239601515807761 no 2589 0.24244754027805 830 97141 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.698748591412667 0.239502644228086 no 2590 0.24235458057359 846 689007 SGTC_1124 fisetin 1.16336 µM -0.699974719832047 0.239095268611339 no 2591 0.241971546124797 836 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_310 1273-0058 1.06 µM -0.699997360437937 0.239087749935509 no 2592 0.241964476437471 802 2734232 SGTC_2142 5622915 118.518 µM -0.700623711884583 0.238879797323975 no 2593 0.241768938255439 840 5322196 SGTC_1372 2752-0194 270 µM -0.702823056960889 0.238150385060369 no 2594 0.24108301317278 826 823334 SGTC_2028 5153890 36.43 µM -0.703142454557224 0.238044558505101 no 2595 0.240983488478471 840 2830968 YPR165W RHO1 SGTC_256 clotrimazole 625 nM -0.703215621806419 0.238020319503624 no 2596 0.240960692617291 810 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1731 st035964 63 µM -0.704314390949257 0.237656479690075 no 2597 0.240618503102455 863 6739575 SGTC_2106 5357045 167.29 µM -0.705244514698037 0.237348722746479 no 2598 0.240329041674724 830 668842 SGTC_3095 9117207 49.47 µM -0.706187053150358 0.237037081430891 no 2599 0.240035910330879 822 17015229 SGTC_757 1066-0008 322 µM -0.70673468552676 0.236856115365001 no 2600 0.239865685142769 829 6842497 SGTC_3160 9100216 49.47 µM -0.70786074980204 0.236484244283065 no 2601 0.239515868094147 824 17191039 SGTC_670 4204-0025 119 µM -0.709288583152151 0.236013179476935 no 2602 0.239072705899903 824 719039 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.709389805094904 0.235979804395337 no 2603 0.239041306273985 834 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2057 5236571 38.335 µM -0.710136690244398 0.235733620493312 no 2604 0.238809687930539 840 54684039 YBR257W POP4 SGTC_1973 st070275 50.2 µM -0.711108442512187 0.235413529326153 no 2605 0.238508519362457 812 17118334 SGTC_1546 5-methoxyflavanone 78.7 µM -0.71180724490516 0.235183495069197 no 2606 0.238292072878912 827 147795 SGTC_3325 9138760 55.175 µM -0.712795099043796 0.234858521603569 no 2607 0.237986279384016 830 43844959 SGTC_430 0958-0115 16.4 µM -0.713920232297237 0.234488690067832 no 2608 0.23763825288745 849 6833180 SGTC_44 0929-0055 61.211 µM -0.714123114137492 0.234422037067105 no 2609 0.237575527157286 831 1379590 SGTC_2824 7998404 51.95 µM -0.716696991353385 0.233577349028996 no 2610 0.236780541363058 858 837851 SGTC_2504 purpurogallin 52.29 µM -0.717306003786366 0.233377732192352 no 2611 0.236592651760778 830 5281571 An antioxidant. SGTC_2292 7671323 168.05 µM -0.717656738429048 0.233262814384178 no 2612 0.236484482023034 864 937504 SGTC_516 3992-2719 87.3 µM -0.720426862517516 0.232356290750146 no 2613 0.235631107810974 837 5350887 YDR037W KRS1 SGTC_3013 9080133 71.4286 µM -0.720667280889987 0.232277706324342 no 2614 0.235557123870525 849 17050193 SGTC_1443 4112-3303 14 µM -0.720716724215951 0.232261546849787 no 2615 0.235541910265893 849 704433 SGTC_1722 st034304 3.6505 µM -0.721765456528642 0.231918938911989 no 2616 0.235219345325317 863 4036148 YLR033W RSC58 SGTC_69 0096-0274 206.684 µM -0.722140623761651 0.231796444780384 no 2617 0.235104012134678 868 6741392 SGTC_1523 st012844 44.7 µM -0.722740533779987 0.231600645830797 no 2618 0.234919653872931 854 4274103 SGTC_2920 7982904 15.77 µM -0.724215412693397 0.231119666197443 no 2619 0.234466748865207 831 6456808 SGTC_1188 1403-0014 4.57 µM -0.726599852306453 0.230343245880528 no 2620 0.233735559372177 840 9614867 SGTC_1192 1488-0095 21.4 µM -0.726843576149577 0.230263966854378 no 2621 0.233660892610584 865 915875 SGTC_1984 st072354 53.1 µM -0.727500663104494 0.230050304218372 no 2622 0.233459654633416 845 5762938 SGTC_2742 clothiapine 36.27 µM -0.728807702081288 0.229625628983433 no 2623 0.233059649767713 830 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3267 9137951 49.47 µM -0.72882377364156 0.229620409843431 no 2624 0.233054733613581 883 16643986 SGTC_2128 5255449 168.493 µM -0.73056151216342 0.229056482173623 no 2625 0.232523513969423 834 736008 SGTC_1625 st003711 30.1 µM -0.731136919683238 0.228869923363545 no 2626 0.23234776271081 859 24207034 YER133W GLC7 SGTC_2354 9060492 162 µM -0.731341613190227 0.228803578139518 no 2627 0.232285259382635 855 6471895 SGTC_2914 7968218 45.32 µM -0.732905661353382 0.228296995668295 no 2628 0.231807984964824 814 2977111 SGTC_2819 7996655 46.38 µM -0.73351096707633 0.228101111399431 no 2629 0.231623420666844 818 6456960 SGTC_3346 9158254 43.5805 µM -0.73384434056416 0.227993268072299 no 2630 0.231521806449347 858 17639500 SGTC_1050 3232-1156 69.3 µM -0.734090228794431 0.227913743821152 no 2631 0.231446874185081 852 700529 SGTC_1386 3228-0095 33.8 µM -0.735890912292244 0.227331849332259 no 2632 0.230898544112366 838 870181 SGTC_2021 4019055 173 µM -0.736037351539006 0.227284564028658 no 2633 0.230853983492371 857 44827708 YER133W GLC7 SGTC_2284 7945075 39.21 µM -0.736228840865938 0.227222740395203 no 2634 0.230795721638512 853 1245402 SGTC_1329 1447-1697 50.6 µM -0.736292600323681 0.227202157323429 no 2635 0.23077632423782 850 2840515 SGTC_3157 9099274 49.47 µM -0.738930836550919 0.226351393718941 no 2636 0.229974498188602 834 17217662 SGTC_250 brefeldin a 552.239 µM -0.741931297664587 0.225386012475738 no 2637 0.229064481011601 844 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_990 3985-0011 41.3 µM -0.741979582317756 0.2253704962467 no 2638 0.229049853175442 854 5399565 YGL099W LSG1 SGTC_1954 st077032 68.9 µM -0.74241946388651 0.225229168563933 no 2639 0.228916615185677 863 698907 SGTC_710 3448-4187 58 µM -0.742722178965173 0.225131939686613 no 2640 0.228824949529874 841 3946412 SGTC_2687 chenodiol 100 µM -0.742738475567881 0.225126706065033 no 2641 0.228820015313057 823 5702181 A cholesterol synthesis inhibitor. SGTC_408 cantharidin 100 µM -0.742987538675658 0.225046728520112 no 2642 0.228744612464679 840 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1782 st039423 80.636 µM -0.743004683298632 0.225041223741288 no 2643 0.228739422512663 850 2068169 SGTC_762 1165-0429 115 µM -0.745249064550176 0.22432125909396 no 2644 0.228060583420855 846 5967793 SGTC_2222 6885208 172.143 µM -0.746870735301555 0.223801865601168 no 2645 0.227570796247893 845 609514 SGTC_3102 9121669 49.47 µM -0.747328597343561 0.223655344037051 no 2646 0.227432617181354 869 41905072 SGTC_3283 9109332 35.8195 µM -0.748089953202776 0.223411821469848 no 2647 0.227202950798851 823 17027281 SGTC_3188 9110789 49.47 µM -0.748275134000165 0.223352613504881 no 2648 0.227147109956807 869 849217 SGTC_1743 st037606 46.3785 µM -0.74854490659095 0.223266374937097 no 2649 0.227065774500862 836 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_709 3807-1509 243 µM -0.749381167744706 0.222999166670726 no 2650 0.226813749173552 880 1886677 YPL242C IQG1 SGTC_594 1487-1584 10.8 µM -0.749401010959742 0.222992828434858 no 2651 0.22680777091029 873 5013332 SGTC_984 1492-0255 2.91 µM -0.750072423089514 0.222778429288988 no 2652 0.226605543665983 847 1585198 SGTC_1679 SEC14.276 6.7 µM -0.750276071095079 0.222713422473445 no 2653 0.22654422564339 846 1005053 YMR079W SEC14 SGTC_3069 9117009 49.47 µM -0.750613942834827 0.222605593730136 no 2654 0.226442513778103 833 41904981 SGTC_1139 k015-0024 46.9 µM -0.754254028518423 0.221445782143712 no 2655 0.225348350439703 859 2766652 SGTC_2094 5332512 191.667 µM -0.75512041192818 0.221170243148307 no 2656 0.225088368387102 851 755774 SGTC_2085 5307070 144.047 µM -0.756575105546397 0.220708043202315 no 2657 0.224652230216777 874 2840351 SGTC_209 4077-0173 175.592 µM -0.756732977543156 0.220657915816488 no 2658 0.224604926760953 838 15993494 SGTC_1503 4585-0012 61.3 µM -0.757030827299881 0.220563360569002 no 2659 0.224515696918042 852 2922052 SGTC_1261 0712-0010 12.7 µM -0.759666074840472 0.219727788061668 no 2660 0.2237271061165 852 2840123 SGTC_3308 9128332 17.569 µM -0.761069052422484 0.219283680560633 no 2661 0.223307911991695 824 17332805 YDL196W YDL196W SGTC_2835 9006588 71.43 µM -0.76257658227604 0.218807052924311 no 2662 0.222857977428845 823 2345538 SGTC_2985 9022375 71.43 µM -0.762869370087898 0.218714552949863 no 2663 0.222770652458495 867 4939335 SGTC_3135 9127742 49.47 µM -0.767363595333498 0.21729752648795 no 2664 0.221432683454209 868 3643468 SGTC_2996 9066192 71.4286 µM -0.767729298044802 0.217182454386843 no 2665 0.221324013164858 849 6472854 SGTC_1913 st060213 96.1 µM -0.768662176720385 0.216889074047568 no 2666 0.221046942034375 872 688959 SGTC_2477 5967686 25.23 µM -0.769874042106937 0.216508297710089 no 2667 0.220687306604695 870 776118 SGTC_3201 9113999 49.47 µM -0.770154115982283 0.216420351654302 no 2668 0.220604239062904 862 16649224 SGTC_177 1327-0068 8.361 µM -0.770209135100629 0.216403077519473 no 2669 0.220587922963242 851 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3312 9133330 71.43 µM -0.77083333383538 0.21620715620192 no 2670 0.220402863207551 879 17617324 SGTC_1866 st057638 64 µM -0.770963147544456 0.216166423633395 no 2671 0.220364387778412 843 688802 SGTC_3173 9105693 49.47 µM -0.771882772886139 0.215877993541687 no 2672 0.22009193069475 874 17096658 SGTC_913 3487-1245 167 µM -0.772176348848842 0.215785963742325 no 2673 0.220004993751433 855 4016153 SGTC_2187 6125751 200 µM -0.77296340355264 0.215539351119844 no 2674 0.219772019694237 866 874498 SGTC_10 0279-0212 42.575 µM -0.776731605334609 0.214360904551024 no 2675 0.218658568017038 848 39851 YBR002C RER2 SGTC_417 st075190 100 µM -0.778135248143888 0.213922896769502 no 2676 0.218244642432289 870 222757 SGTC_1863 st057641 20.1 µM -0.77905244041808 0.213636967937307 no 2677 0.217974412176846 883 3921635 SGTC_1604 st002052 72.4 µM -0.780541671642143 0.213173184175253 no 2678 0.217536054577092 855 6254834 YHR062C RPP1 SGTC_657 3534-0529 86.7 µM -0.781447223698963 0.212891459994493 no 2679 0.217269752829557 882 1049549 SGTC_1493 4348-0038 111 µM -0.782382463502657 0.212600727951054 no 2680 0.216994918353211 878 800424 SGTC_3313 9133968 57.047 µM -0.782651160063707 0.212517242860773 no 2681 0.216915994942121 851 1494643 SGTC_2576 guaiol 23.12 µM -0.783151684573957 0.212361778976013 no 2682 0.216769021675091 842 227829 SGTC_202 3594-0513 34.79 µM -0.785018194489624 0.211782623674873 no 2683 0.216221450515305 862 708429 SGTC_1094 duloxetine 25.4 µM -0.78622142434198 0.211409766542976 no 2684 0.215868888349034 841 60834 A selective serotonin reuptake inhibitor. SGTC_2565 isoliquiritigenin 100 µM -0.786314945671619 0.211380802243798 no 2685 0.215841499329886 836 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1205 4161-2785 76 µM -0.78764634575683 0.210968709192135 no 2686 0.215451798815038 861 3498106 SGTC_1201 1889-3372 45.9 µM -0.787968427461565 0.210869089721696 no 2687 0.215357586916907 851 5392199 SGTC_2408 sulbentine 18.36 µM -0.7880560179213 0.210842002873188 no 2688 0.215331970026384 846 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2381 9035592 200 µM -0.788205256591649 0.210795856368658 no 2689 0.215288327443098 880 4749657 SGTC_3356 9151811 4.48 µM -0.78875469259646 0.210626014790554 no 2690 0.215127697467257 873 1859254 YPR165W RHO1 SGTC_2374 9071832 200 µM -0.792392961755797 0.209503381402015 no 2691 0.21406579101267 849 17381698 SGTC_2159 5658611 73.75 µM -0.795808177957682 0.208452783717997 no 2692 0.213071768843665 892 793844 SGTC_59 0330-0160 1.33 µM -0.796290779160519 0.20830457562851 no 2693 0.212931521904128 880 4293482 SGTC_1066 ketoconazole 628 nM -0.799825221845213 0.207221035242926 no 2694 0.211906033878083 872 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2861 9024595 19.48 µM -0.800654962913098 0.206967148703638 no 2695 0.211665711073317 837 16482810 SGTC_3125 9127534 49.47 µM -0.800811720522076 0.206919204244507 no 2696 0.211620326364205 841 1639235 SGTC_2395 5646831 180.19 µM -0.801328347302718 0.206761240003519 no 2697 0.211470792096393 873 6808628 SGTC_1771 st048882 4.1505 µM -0.802372597634193 0.206442167226373 no 2698 0.211168729617031 875 4580403 SGTC_1314 1222-0010 41.1 µM -0.802763680702756 0.20632274614027 no 2699 0.211055669052491 883 3526027 SGTC_2597 laccaic acid a 100 µM -0.804218933994504 0.205878729898094 no 2700 0.210635272876366 892 5491415 A textile dye. SGTC_2146 5545642 200 µM -0.804942006680051 0.205658322218453 no 2701 0.210426573183411 865 825326 SGTC_169 k015-0017 16.025 µM -0.805051204597876 0.205625048585811 no 2702 0.210395066058917 906 1840002 SGTC_2938 9059746 27.26 µM -0.805331950598932 0.20553951730907 no 2703 0.210314074488766 891 6471769 SGTC_2955 9076254 12.21 µM -0.807267134063277 0.204950524667156 no 2704 0.209756297427479 859 16459619 SGTC_1897 st060201 15 µM -0.807884632499363 0.204762794162526 no 2705 0.209578499335191 880 611878 SGTC_1596 piperlongumine 63 µM -0.808404714643193 0.204604759317134 no 2706 0.209428819388744 870 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1393 3470-5649 58.2 µM -0.810258686849155 0.204041992492988 no 2707 0.208895757105693 856 4108395 SGTC_3279 9140807 49.47 µM -0.812254569421635 0.203437181182613 no 2708 0.208322786523497 892 45595718 SGTC_3004 9076122 71.4286 µM -0.812471252851933 0.203371584130359 no 2709 0.208260637683186 887 44782551 SGTC_652 0437-0092 114 µM -0.814332738709319 0.202808572508663 no 2710 0.20772717970016 862 3091274 SGTC_930 2810-3379 265 µM -0.814997109324354 0.202607857444626 no 2711 0.207536982364801 893 1015764 SGTC_964 1287-0107 19.4 µM -0.816043150534646 0.202292075437967 no 2712 0.20723772829265 877 51516812 YPR165W RHO1 SGTC_1670 st016595 4.04 µM -0.816522428663845 0.202147487938287 no 2713 0.207100700504056 889 597879 SGTC_2087 5276107 200 µM -0.81655687918521 0.20213709736854 no 2714 0.207090853009187 868 144405 SGTC_384 k007-0144 5.16 µM -0.818878037400082 0.201437752694573 no 2715 0.206428000807192 900 6824886 SGTC_821 1114-0266 29.2 µM -0.819813424036522 0.201156339282354 no 2716 0.20616123858706 867 3123235 SGTC_949 1165-0505 146 µM -0.820679271773025 0.200896057056109 no 2717 0.205914490360732 884 6244267 SGTC_2750 bromebric acid 70.15 µM -0.821462697427227 0.200660725937352 no 2718 0.205691381716755 892 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2376 9072922 81.32 µM -0.821686449993323 0.200593543903215 no 2719 0.205627686472475 889 17087968 SGTC_3332 9141069 11.198 µM -0.823237837746017 0.200128109028336 no 2720 0.205186377795244 878 17332883 SGTC_1947 st076332 61.6 µM -0.823539719183686 0.200037616490326 no 2721 0.205100569878232 881 24208416 SGTC_3034 9090421 49.47 µM -0.825387197454492 0.199484349123648 no 2722 0.204575900496283 855 17173761 SGTC_2752 diclazuril 33.15 µM -0.825458806111028 0.199462922920565 no 2723 0.204555580288082 875 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1432 4049-0298 68.4 µM -0.826684189118281 0.199096487767098 no 2724 0.204208042597777 881 741646 SGTC_1186 1319-0216 26 µM -0.826921793425763 0.199025482203541 no 2725 0.204140695043449 893 4565136 SGTC_2015 5119600 184 µM -0.82736199631668 0.198893972499642 no 2726 0.204015957067667 879 2828786 SGTC_955 1216-0110 33 µM -0.827693373662246 0.198795008765376 no 2727 0.203922086379864 885 3619719 SGTC_2987 9018338 71.43 µM -0.831055661060883 0.197792562668717 no 2728 0.202971093030245 863 5055682 SGTC_1280 0880-0253 10.1 µM -0.837209304133121 0.195965819142017 no 2729 0.201237464265777 884 6836607 SGTC_424 splitomicin 100 mM -0.837907314797591 0.195759259070739 no 2730 0.201041380120231 904 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1414 3917-0015 5.4 µM -0.838551605855911 0.195568713406277 no 2731 0.200860488562078 873 6618702 SGTC_48 0382-0018 55 µM -0.83937439083376 0.195325542920581 no 2732 0.200629624998445 880 762596 SGTC_145 3737-0113 38.366 µM -0.839855293078367 0.195183499473336 no 2733 0.200494763415852 868 6849351 SGTC_327 1273-0057 3.96 µM -0.840572140462708 0.194971881796749 no 2734 0.200293835768379 867 3108138 SGTC_3051 9093778 49.47 µM -0.840686640180801 0.194938093713728 no 2735 0.200261753453447 917 17217378 SGTC_2140 5586273 200 µM -0.84229698534227 0.194463269133339 no 2736 0.199810869038372 886 854421 SGTC_941 3237-0776 460 µM -0.842476384936656 0.194410415186771 no 2737 0.199760676343711 882 760008 SGTC_2594 a-mangostin 100 µM -0.842498972664073 0.194403761106369 no 2738 0.199754357252219 892 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2417 cerulenin 830 nM -0.843658920756781 0.194062240363399 no 2739 0.19943001446855 880 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3288 9119690 36.221 µM -0.844080517612496 0.193938201235406 no 2740 0.19931220684886 914 17595618 YKL019W RAM2 SGTC_1410 3909-8106 77.9 µM -0.845167264161042 0.193618689509975 no 2741 0.199008728464092 880 1039210 SGTC_2210 7115885 190.385 µM -0.84782501258137 0.192838644926058 no 2742 0.198267715506303 895 2927039 SGTC_3350 9150499 3.57 µM -0.848151509614498 0.192742951189945 no 2743 0.198176799117314 892 4910996 YPR165W RHO1 SGTC_1720 st037298 9.481 µM -0.848670069260179 0.192591025048269 no 2744 0.198032452700058 902 597396 SGTC_2557 derrustone 83.84 µM -0.852186383823216 0.191562757233603 no 2745 0.197055326357112 890 629853 An antioxidant. SGTC_1961 st076550 68.7 µM -0.854716907359484 0.190824847164249 no 2746 0.19635394410751 898 1579337 SGTC_2371 9071574 200 µM -0.854773859123198 0.190808259910898 no 2747 0.196338176285361 903 45596039 SGTC_1199 1638-0010 4.46 µM -0.860332365407353 0.189193599113182 no 2748 0.19480292837332 886 3111136 SGTC_1998 st075797 76.8 µM -0.861595116855477 0.188827965305287 no 2749 0.194455179539957 877 24208315 SGTC_3 0833-0587 95.581 µM -0.862612945532506 0.188533566860276 no 2750 0.194175155161675 894 5382644 SGTC_2847 9005661 71.43 µM -0.863291905642861 0.188337340776311 no 2751 0.193988496726712 865 2991449 SGTC_1779 st039427 55 µM -0.865857806265388 0.187596908900114 no 2752 0.193284072075099 894 1124498 SGTC_2747 doxorubicin 7.63 µM -0.86694079967284 0.187284934254623 no 2753 0.1929872236254 819 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_407 eburnamonine 100 µM -0.867045737278258 0.18725472225122 no 2754 0.192958475034832 875 3195 SGTC_3024 9090631 49.47 µM -0.869603857322647 0.18651916050344 no 2755 0.192258464536217 865 25236383 SGTC_2135 5326629 150.42 µM -0.870077624764437 0.186383130077909 no 2756 0.192128992285333 904 5020077 SGTC_1195 1502-0147 41.1 µM -0.870265173930014 0.186329297028478 no 2757 0.192077753162311 886 817940 SGTC_2017 5132927 60.65 µM -0.87274994601917 0.185616991656557 no 2758 0.191399693751216 893 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1753 st043925 64 µM -0.873232614447759 0.185478822159398 no 2759 0.191268150656886 911 670181 SGTC_1871 st057448 67.3 µM -0.875680732812124 0.184779003027448 no 2760 0.190601811247172 890 691747 SGTC_486 niguldipine 82 µM -0.876157406125196 0.184642932339034 no 2761 0.190472234190751 882 1236 A calcium channel blocker. SGTC_3101 9120531 49.47 µM -0.877013571855266 0.184398688624834 no 2762 0.190239633230767 911 24824904 SGTC_3205 9113483 49.47 µM -0.878700012088908 0.18391817555655 no 2763 0.189781976053866 903 17018033 SGTC_735 3076-0345 636 µM -0.879051479920408 0.183818131009293 no 2764 0.189686681909319 890 2888990 SGTC_1986 st071812 45 µM -0.880106788160438 0.183517943576299 no 2765 0.189400731070543 903 11838594 SGTC_1308 1187-1617 41.4 µM -0.880408889515303 0.183432065698842 no 2766 0.189318921265071 899 2882570 SGTC_3084 9116877 49.47 µM -0.880490927201886 0.183408749300523 no 2767 0.189296709009699 869 27241325 SGTC_3236 9132701 49.47 µM -0.881432913771028 0.183141154357476 no 2768 0.189041774796987 913 24282524 SGTC_1340 1486-1359 257 µM -0.881993437493497 0.182982039149697 no 2769 0.18889017805726 873 4309068 SGTC_679 0422-0091 41.4 µM -0.882307055048539 0.182893050549613 no 2770 0.188805391144232 912 627384 YHR062C RPP1 SGTC_3003 9075612 71.4286 µM -0.883754509492486 0.182482687202677 no 2771 0.188414373962109 913 6501993 SGTC_642 0335-0876 158 µM -0.88406440445488 0.182394904643436 no 2772 0.188330723503413 902 6812350 SGTC_2972 9093619 59.92 µM -0.884476294143525 0.182278271337714 no 2773 0.188219576908217 886 25236256 SGTC_1203 3992-3522 103 µM -0.885121859017969 0.182095562873027 no 2774 0.188045455558566 914 5322312 SGTC_2839 9003951 25.97 µM -0.885320625089433 0.182039330946176 no 2775 0.187991864525758 874 2990634 SGTC_3306 9127676 59.7925 µM -0.889459205823248 0.180870972900633 no 2776 0.186878168991893 886 41905287 SGTC_2507 purpurin 79.67 µM -0.891107546930579 0.180406943270326 no 2777 0.18643573827958 909 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1142 3253-1408 9.78 µM -0.89218177341326 0.18010493678369 no 2778 0.186147754980975 901 256655 SGTC_1310 1188-0297 994 nM -0.892823568493945 0.179924654984266 no 2779 0.185975831410862 885 1588352 SGTC_1801 st050089 28.441 µM -0.893095472406852 0.179848310703537 no 2780 0.185903023700869 896 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2511 berberine 10.47 µM -0.893574610669539 0.17971382937495 no 2781 0.185774767873445 899 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1347 1493-0251 600 nM -0.894077646239316 0.179572708714274 no 2782 0.185640174286124 857 3986378 SGTC_1736 st036774 51 µM -0.895112448209759 0.179282626364058 no 2783 0.185363490119463 912 1272247 SGTC_1608 st001473 40.5 µM -0.897629067268832 0.178578382151148 no 2784 0.184691668549927 912 7292267 SGTC_873 0591-4978 488 µM -0.898057467749556 0.178458673422991 no 2785 0.184577456288495 896 3305145 SGTC_3150 9097574 49.47 µM -0.899292475262835 0.178113856023314 no 2786 0.184248447180245 880 17217476 SGTC_1315 1237-0019 3.69 µM -0.90283964720218 0.177125813688383 no 2787 0.183305502824669 898 825140 SGTC_2675 theaflavin digallate 100 µM -0.9038787239818 0.176837042317957 no 2788 0.18302985599728 911 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_768 0384-0033 77.3 µM -0.904437846257934 0.176681779028895 no 2789 0.182881638828892 884 3965305 YMR134W ERG29 SGTC_1485 3909-9022 254 µM -0.906555463782766 0.176094517186095 no 2790 0.182320961110347 925 714516 SGTC_2443 5493264 126.67 µM -0.907426050392338 0.175853443246156 no 2791 0.182090769375185 915 5340055 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.908001226397187 0.175694286115652 no 2792 0.181938786852933 918 6710655 SGTC_170 4197-0004 226 µM -0.908453638954634 0.175569163041328 no 2793 0.181819298675624 910 218692 SGTC_582 0987-0078 156 µM -0.909298613386788 0.175335620980374 no 2794 0.181596261174376 916 1625765 SGTC_1748 st037455 53.6035 µM -0.909757792771693 0.175208791260806 no 2795 0.181475129079942 902 580690 SGTC_2640 pentamidine 10.38 µM -0.91232541767076 0.174500661519656 no 2796 0.180798718942896 878 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3258 9138477 49.47 µM -0.915005262732878 0.173763523914534 no 2797 0.180094433664124 923 4970355 SGTC_803 4488-1585 147 µM -0.916310713617595 0.173405155648953 no 2798 0.179751975176862 896 747204 SGTC_67 0335-0847 266 µM -0.917966247564307 0.172951360854545 no 2799 0.179318268340086 936 4552207 YOR254C SEC63 SGTC_3204 9114183 49.47 µM -0.918110855858826 0.172911758555938 no 2800 0.179280416002191 904 17027248 SGTC_374 0880-0231 82.3 µM -0.920413433613977 0.17228195530781 no 2801 0.178678375619084 899 6833587 SGTC_969 1313-0238 134 µM -0.92062241103002 0.17222486814191 no 2802 0.178623798701813 913 5212874 SGTC_336 4111-0029 111 µM -0.920707134413982 0.172201727367897 no 2803 0.178601675181762 913 3131175 SGTC_1545 lovastatin 49.4 µM -0.92127149434349 0.172047632532475 no 2804 0.178454349887658 902 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_162 k030-0015 37.8 µM -0.922094121533652 0.171823177201311 no 2805 0.178239741487553 927 1809920 YMR134W ERG29 SGTC_479 n-linoleoylglycine 10 µM -0.92268824935213 0.171661184699741 no 2806 0.178084845600632 918 6433346 An anti-infammatory. SGTC_2325 6158266 200 µM -0.92463283918314 0.171131663188746 no 2807 0.177578462553444 907 3623240 SGTC_2553 4-methylesculetin 85.09 µM -0.927936055057866 0.170234578145886 no 2808 0.176720370189333 907 5319502 SGTC_2029 5175081 200 µM -0.928335178676631 0.170126388817958 no 2809 0.176616865719911 901 1380876 SGTC_891 0929-0073 133 µM -0.930282551419026 0.169599152054642 no 2810 0.176112404790082 921 5603632 SGTC_268 camptothecin 39.6153 µM -0.931383906701058 0.169301432820072 no 2811 0.175827506287695 924 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_396 dithiazanine 1.25 µM -0.931898193435434 0.169162525394633 no 2812 0.175694570674306 905 10578 An antihelmenthic. SGTC_416 estradiol valerate 100 µM -0.93234901557974 0.169040819787709 no 2813 0.175578092121281 915 13791 A steroid. SGTC_556 4058-0063 51.5 µM -0.932385562446535 0.169030955925786 no 2814 0.175568651681702 932 6615692 SGTC_1114 scopoletin 1.73284 µM -0.933159782471658 0.168822083721172 no 2815 0.175368738108795 914 5280460 A coumarin with genotoxic properties. SGTC_867 0518-0118 155 µM -0.934442136917758 0.168476489953078 no 2816 0.175037935311209 902 6848158 SGTC_1799 st045822 46.1415 µM -0.935073042297675 0.16830662839682 no 2817 0.174875329085033 871 3674992 SGTC_2711 st079103 59.1 µM -0.938406646929806 0.167410936200684 no 2818 0.174017735670398 919 54693780 SGTC_1702 st027038 51 µM -0.938635173783404 0.167349646983186 no 2819 0.173959043611105 915 5521182 SGTC_433 pimozide 108 µM -0.939037508848917 0.167241778828219 no 2820 0.173855743353915 914 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2862 9027634 71.43 µM -0.940087245396236 0.166960549981395 no 2821 0.173586405316455 900 5012562 SGTC_585 0kpi-0023 191 µM -0.940469533519716 0.166858209187585 no 2822 0.17348838504435 877 64601 SGTC_2280 7785178 200 µM -0.94056854747477 0.166831709164895 no 2823 0.173463003197328 896 2954328 SGTC_1311 1190-0148 100 µM -0.940611938481856 0.166820096883094 no 2824 0.173451880824234 922 1961333 SGTC_1119 parthenolide 318.541 nM -0.941387086530548 0.166612739976584 no 2825 0.173253264396807 955 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1211 1056-0033 32.3 µM -0.942648351590558 0.16627569946098 no 2826 0.172930399719426 897 6741922 SGTC_1831 st055328 12 µM -0.943220848915639 0.166122859733534 no 2827 0.172783975693706 912 1103068 SGTC_592 k241-0073 46.5 µM -0.943257259610484 0.166113142233645 no 2828 0.172774665833683 910 4230158 SGTC_261 5-fluorouridine 15.376 µM -0.944438153237772 0.165798177520721 no 2829 0.17247289619029 917 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1474 0330-0125 5.35 µM -0.945234436019693 0.165586013235371 no 2830 0.172269601210126 939 X1474 SGTC_480 am 92016 50 µM -0.947286536655472 0.16504005429144 no 2831 0.171746394700345 933 2129 K+ channel blocker. SGTC_166 k072-0058 166.424 µM -0.947843527883054 0.164892068760687 no 2832 0.171604558735789 913 5846229 SGTC_1375 2910-0797 186 µM -0.950906365016151 0.164079847735504 no 2833 0.170825955207444 918 742508 SGTC_1968 st069590 43.6 µM -0.951521519592078 0.163917030952224 no 2834 0.170669849863277 909 6384066 SGTC_2261 9010538 184.68 µM -0.952056632238722 0.163775484656404 no 2835 0.170534130734265 916 6457250 SGTC_3335 9143315 29.6265 µM -0.952558125494938 0.163642903292245 no 2836 0.170407001145018 890 4899691 SGTC_1777 st045864 34.765 µM -0.953145249566246 0.163487772009349 no 2837 0.170258241116786 939 4691462 SGTC_287 k060-0039 29.6 µM -0.953176175733239 0.163479603274614 no 2838 0.170250407639975 907 5861974 SGTC_260 nsc-65238 3.989 µM -0.954266995979184 0.163191647220781 no 2839 0.169974254865831 929 3246252 SGTC_1439 4092-1168 46 µM -0.954320488125513 0.163177534781993 no 2840 0.16996072014849 933 2886240 SGTC_325 2810-4341 181 µM -0.955590189592529 0.162842791638015 no 2841 0.169639659931389 892 774970 SGTC_819 1013-0258 27.7 µM -0.957352345797938 0.162378958550052 no 2842 0.169194721343583 925 5753198 SGTC_421 streptovitacin 30 mM -0.957438212563687 0.162356378774739 no 2843 0.169173059432559 947 91467 include heat shock SGTC_1837 st055472 66.5 µM -0.958678331393141 0.162030501425994 no 2844 0.168860408880582 917 676091 SGTC_567 1080-0542 68.4 µM -0.959755111944984 0.161747891764895 no 2845 0.168589239403789 882 5950415 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.960173410367538 0.161638192686933 no 2846 0.16848397336145 902 688664 SGTC_2586 curcumin 80 µM -0.961565186988885 0.161273547415499 no 2847 0.16813403294164 936 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1385 3091-4834 14.1 µM -0.961708047285615 0.161236148428839 no 2848 0.168098139443032 907 4072814 SGTC_3106 9121286 49.47 µM -0.962745186102234 0.160964808483648 no 2849 0.167837707259474 895 15943471 SGTC_2591 skatole 100 µM -0.963939005441039 0.160652846423703 no 2850 0.167538253371977 927 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_356 1634-0012 32.5 µM -0.964851502897136 0.160414664231616 no 2851 0.167309597607925 925 735457 SGTC_1301 naphtanilide LB 4.81 µM -0.967475345213084 0.159731069158287 no 2852 0.16665323025464 904 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_625 k213-0058 121 µM -0.967539322446181 0.159714424876024 no 2853 0.16663724680909 927 3655420 SGTC_235 0330-0087 5 mM -0.968530849065147 0.159456614935585 no 2854 0.166389659992313 925 46494818 YHR062C RPP1 SGTC_2030 5175110 200 µM -0.9732575443704 0.158231359123677 no 2855 0.165212658690712 943 2831986 SGTC_1757 st041620 31.8375 µM -0.975163204023927 0.157739125478614 no 2856 0.164739655546935 955 5289815 SGTC_1288 0973-0013 65.5 µM -0.978712809343979 0.156824943620938 no 2857 0.16386095056931 923 4315430 SGTC_2890 9046729 58.44 µM -0.978988210157757 0.15675416164771 no 2858 0.163792902466617 912 903329 SGTC_1068 loratadine 26.9 µM -0.979260707264002 0.156684146666043 no 2859 0.163725589888959 946 3957 A H1 histamine antagonist. SGTC_3029 9088683 49.47 µM -0.982682908629568 0.155806604324541 no 2860 0.162881762547838 918 25236615 SGTC_294 k038-0071 157 µM -0.983431699727002 0.1556150275462 no 2861 0.162697507547359 933 24152826 SGTC_779 1360-0071 233 µM -0.984056248457216 0.155455356831698 no 2862 0.162543928604542 904 7566 SGTC_697 0508-1955 564 µM -0.985297668474829 0.155138299281766 no 2863 0.162238938818562 921 6243113 SGTC_3043 9092303 49.47 µM -0.985918128577896 0.154979994453004 no 2864 0.162086645055705 922 25236084 SGTC_2551 apiole 73.87 µM -0.986298165215609 0.154883084214649 no 2865 0.161993409934185 903 10659 A possible DNA adduct former. SGTC_2224 6650123 117.647 µM -0.987362389423429 0.154611917562949 no 2866 0.161732507678789 941 2908370 SGTC_1054 3429-0080 167 µM -0.996805936173151 0.152219432555474 no 2867 0.159429358165656 940 1162877 SGTC_63 0099-0242 26.702 µM -0.997057987970378 0.152155914838812 no 2868 0.15936818189321 926 3898502 YLR359W ADE13 SGTC_1903 st060211 78.3 µM -0.997071107643907 0.152152609128485 no 2869 0.159364997997509 914 688960 SGTC_788 1182-0090 188 µM -0.997504153960491 0.152043522990029 no 2870 0.159259929252902 923 5715185 SGTC_1669 st015249 58.4 µM -0.99784465891166 0.151957784888396 no 2871 0.159177345412674 950 722793 SGTC_1240 0356-0016 42.1 µM -0.998526253042465 0.151786258082813 no 2872 0.159012120322184 884 4305613 SGTC_1218 1348-1416 30.7 µM -0.999363505389415 0.151575735205521 no 2873 0.158809316007772 917 6787668 SGTC_2718 lomofungin 53.02 µM -0.99968323154403 0.151495392916434 no 2874 0.158731914764197 933 5351222 A RNA synthesis inhibitor. SGTC_659 k018-0002 107 µM -1.00251523302326 0.150784990526953 no 2875 0.15804740657513 941 6797879 YHR007C ERG11 SGTC_2009 4012297 12.05 µM -1.00308057377659 0.150643441828266 no 2876 0.157910993404184 924 45595307 SGTC_2220 6782180 200 µM -1.00381401449443 0.150459936564451 no 2877 0.157734134015212 911 833803 SGTC_2104 5389443 200 µM -1.00528407104067 0.150092580169874 no 2878 0.157380041499143 951 2244536 SGTC_2205 7238770 200 µM -1.00561097031593 0.150010971763487 no 2879 0.157301372339586 927 279867 SGTC_16 erodoxin 22.806 µM -1.00653445455772 0.149780589436754 no 2880 0.157079273156714 934 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_852 0418-0143 439 µM -1.00736739109845 0.149572998656151 no 2881 0.15687912780836 894 5369229 SGTC_231 b-estradiol 524 µM -1.01042473499751 0.148812670578317 no 2882 0.156145921109857 942 450 A steroid. SGTC_3155 9099265 49.47 µM -1.01153305000285 0.148537683729196 no 2883 0.155880685523776 935 25236499 SGTC_2101 5377231 179.231 µM -1.01348996446326 0.148052978782194 no 2884 0.155413093602915 956 2844213 SGTC_2840 9008771 71.43 µM -1.02066258554755 0.146285462637793 no 2885 0.153707163261841 897 2992978 SGTC_100 0086-0128 49.5915 µM -1.02075589398097 0.146262562827562 no 2886 0.153685052857444 934 93297 SGTC_2735 sertaconazole 140 nM -1.02310029193404 0.145687989384489 no 2887 0.153130214471498 996 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1045 1348-1485 165 µM -1.0237334742036 0.145533067420101 no 2888 0.152980589984454 935 6810614 SGTC_2941 9056145 11.23 µM -1.02450603601252 0.145344193286903 no 2889 0.152798160657449 927 2119517 SGTC_3301 9125354 19.7965 µM -1.02477447007089 0.145278605764936 no 2890 0.152734807614852 907 41905162 SGTC_1213 1315-0166 115 µM -1.02525239272325 0.145161882385842 no 2891 0.152622056360403 923 768401 SGTC_1472 k841-0093 193 µM -1.02534406758686 0.145139499786569 no 2892 0.152600434789643 942 X1472 SGTC_1830 st055982 50.3 µM -1.02654725516239 0.14484595443788 no 2893 0.152316850655991 952 455313 An antimicrobial agent. SGTC_3040 9091894 49.47 µM -1.02755758347692 0.144599770543833 no 2894 0.152078992680476 894 25236966 SGTC_208 k072-0098 12.366 µM -1.0301673364395 0.143965164354162 no 2895 0.151465730007533 949 5948901 SGTC_1820 st053765 18.6 µM -1.03170850439971 0.143591286448369 no 2896 0.151104346118149 941 3690829 SGTC_944 3370-0224 231 µM -1.03296060173483 0.143288018216177 no 2897 0.150811168260161 947 4580514 SGTC_402 epigallocatechin gallate 10 µM -1.03631672552806 0.142477272387074 no 2898 0.15002720287188 935 65064 An antioxidant. SGTC_2489 cantharidin 73.42 µM -1.03633749020455 0.142472265897918 no 2899 0.150022360872033 924 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2915 7971052 15.16 µM -1.03708618469404 0.142291830615004 no 2900 0.149847846559122 903 5741558 SGTC_3213 9129884 49.47 µM -1.04533378072951 0.140314394218373 no 2901 0.147934365055849 940 17190742 SGTC_1177 0983-0204 23.6 µM -1.04629821333926 0.140084387397613 no 2902 0.147711685029901 913 766818 SGTC_2066 5222451 176 µM -1.04764993047998 0.139762448704332 no 2903 0.147399961977902 909 2281147 SGTC_1355 1499-0035 1.68 µM -1.04827790603327 0.139613054911985 no 2904 0.147255292956936 965 1548538 SGTC_369 0957-0393 4.5 µM -1.04899830044497 0.139441808690005 no 2905 0.147089450316561 954 6997992 SGTC_2512 diallyl trisulfide 49.23 µM -1.04954335264919 0.139312338357475 no 2906 0.146964056613521 970 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2801 7907800 81.82 µM -1.05066660725618 0.139045781306336 no 2907 0.146705868901288 923 6620925 SGTC_2765 myclobutanil 7.74 µM -1.05340857343599 0.138396550360908 no 2908 0.146076888259277 953 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1687 st020778 55.3625 µM -1.05560063327292 0.137879012208276 no 2909 0.145575355736886 944 4259299 SGTC_1116 jasmonic acid  1.58368 µM -1.0581780253626 0.137272189195593 no 2910 0.144987143799486 940 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2456 5770359 74.46 µM -1.05846197728383 0.137205447074088 no 2911 0.144922438326573 946 3118787 SGTC_1852 st056254 31.4 µM -1.05875539566603 0.137136503176803 no 2912 0.144855596113862 938 442583 SGTC_1952 st077036 64.1 µM -1.06043390798193 0.136742561652032 no 2913 0.144473621472721 940 2937007 SGTC_1137 ixabepilone 100 µM -1.06096436272255 0.136618226643609 no 2914 0.144353048544872 932 154225 A novel microtubule stabilizer. SGTC_2977 9011197 71.43 µM -1.06115212829521 0.13657423419264 no 2915 0.144310385486698 915 2704722 SGTC_95 0471-0001 561.058 µM -1.0633558926689 0.136058628279679 no 2916 0.143810293548732 936 4015405 SGTC_328 k915-0120 63.5 µM -1.06363229717551 0.135994053191495 no 2917 0.143747652736474 936 6624543 SGTC_1089 terbinafine 2.25 µM -1.06367775417654 0.135983435294983 no 2918 0.143737352701335 928 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.06614250299561 0.135408566103014 no 2919 0.143179614381193 948 368090 SGTC_64 000l-0018 272.079 µM -1.06891354862368 0.134764248843154 no 2920 0.14255431316501 939 6811119 SGTC_2797 7859098 81.82 µM -1.06916643668378 0.134705552811198 no 2921 0.142497339727259 922 972681 SGTC_3176 9106582 49.47 µM -1.07095573835019 0.134290752059594 no 2922 0.142094665924058 914 17018027 SGTC_2336 9001819 198.65 µM -1.07442295209443 0.133489472082447 no 2923 0.141316580030252 925 2989602 SGTC_1859 st055998 20 µM -1.07673245836723 0.13295756881547 no 2924 0.140799903584868 961 676301 SGTC_2736 butenafine 14.65 µM -1.07960594556565 0.132297814435359 no 2925 0.140158846357284 942 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1159 4092-0538 61.2 µM -1.0814030517392 0.131886346613139 no 2926 0.139758932377938 975 717301 SGTC_489 paxilline 115 µM -1.08360549257815 0.131383277835141 no 2927 0.139269877235671 964 105008 A toxic potassium channel blocker. SGTC_1590 st077108 57.8 µM -1.08420432859619 0.131246724573451 no 2928 0.139137106434401 934 5489485 SGTC_2962 9082311 13.18 µM -1.08469265618299 0.131135443253824 no 2929 0.139028900775299 943 16459453 SGTC_455 paf C-16 10 µM -1.08578233342557 0.130887359894032 no 2930 0.13878765213861 940 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1502 4534-4282 27.7 µM -1.08751233167178 0.130494163258695 no 2931 0.138405225840347 976 3278949 SGTC_338 4055-0136 114 µM -1.09106376246186 0.129689550361776 no 2932 0.137622413358269 954 2900563 SGTC_2922 7999257 32.47 µM -1.09159197162002 0.129570173348002 no 2933 0.13750624325198 973 2988377 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.09209266643211 0.129457084964364 no 2934 0.137396186253239 905 279621 SGTC_2581 avocatin a 64 µM -1.09457230281651 0.128898035206303 no 2935 0.136852027644197 969 6710728 A skin care supplement. SGTC_195 4234-0266 16.654 µM -1.09783283239105 0.12816547982968 no 2936 0.136138745947546 951 2303354 SGTC_1435 4092-0789 56.7 µM -1.09800311566676 0.128127301257402 no 2937 0.136101564388783 949 2248285 SGTC_1401 3807-4679 7.6 µM -1.10311697640659 0.126984421172243 no 2938 0.134988184721436 946 3291456 SGTC_2598 perillyl alcohol 100 µM -1.10345700022667 0.126908682727514 no 2939 0.134914377538786 961 10819 An apoptosis inducer. SGTC_1569 carminic acid 40.6 µM -1.10393812457917 0.126801568647227 no 2940 0.134809989710633 946 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_792 4534-1957 155 µM -1.10440601972323 0.126697460211732 no 2941 0.134708525340266 951 1717904 SGTC_1509 1326-1131 80 µM -1.10443853160585 0.126690228407502 no 2942 0.134701476995339 915 768313 SGTC_2932 9016711 44.54 µM -1.1052044335916 0.126519947588559 no 2943 0.134535508094976 967 7117328 SGTC_2893 9048488 25.97 µM -1.10651444297732 0.126229066599409 no 2944 0.134251958083494 976 6467338 SGTC_2397 5161689 200 µM -1.11120144247981 0.125192160484469 no 2945 0.133240825248472 970 2259942 SGTC_2994 9053520 71.4286 µM -1.11142029103366 0.125143890329386 no 2946 0.133193741142012 957 4647384 SGTC_846 0335-0850 148 µM -1.11370495322915 0.124640751654314 no 2947 0.132702891829683 942 6819598 SGTC_1150 3909-7983 10.9 µM -1.11518346929685 0.124315900705058 no 2948 0.132385904201395 956 23965914 SGTC_1660 st012960 28.1 µM -1.11727938268866 0.123856414210145 no 2949 0.131937444001306 951 24207266 SGTC_2244 6635614 200 µM -1.11931079506459 0.123412203981574 no 2950 0.13150378603003 974 836499 SGTC_2655 perillic acid 100 µM -1.12006479062932 0.123247611638539 no 2951 0.1313430766595 972 5702197 An apoptosis inducer. SGTC_3048 9093155 49.47 µM -1.12212037282475 0.122799672894 no 2952 0.130905631382338 918 25236002 SGTC_1324 1418-0026 34.4 µM -1.12268348218053 0.122677163337601 no 2953 0.130785972831922 969 1372513 SGTC_3103 9120822 49.47 µM -1.12269494467132 0.122674670459247 no 2954 0.130783537882548 950 17141819 SGTC_1899 st063254 59.6 µM -1.12346945265508 0.122506311702049 no 2955 0.130619083597533 953 3093813 SGTC_1600 coumarin 106 71.1 µM -1.1244279065087 0.122298192235941 no 2956 0.130415769395308 957 100336 A hepatotoxic, DNA x-linker. SGTC_1916 st067606 49.2 µM -1.12456572608352 0.122268286400297 no 2957 0.130386552115076 917 19590279 SGTC_2910 7948405 25.97 µM -1.12480305241162 0.122216800361932 no 2958 0.130336250354119 906 2971328 SGTC_1289 0976-0073 69.1 µM -1.12755950278487 0.121619925460848 no 2959 0.129752998872575 965 3391136 SGTC_1000 4048-0884 8.67 µM -1.13001835603188 0.121089222890326 no 2960 0.129234244929422 970 13040088 SGTC_605 1315-0399 119 µM -1.13024814923968 0.121039709215409 no 2961 0.12918583811048 957 24020461 SGTC_877 0771-0151 33.1 µM -1.13031231521582 0.12102588587991 no 2962 0.129172323547157 963 6166523 SGTC_2062 5245942 200 µM -1.13039152087795 0.121008824062716 no 2963 0.129155642694314 981 1376160 SGTC_991 3996-0057 64.7 µM -1.13057207082199 0.120969937838946 no 2964 0.12911762413819 949 715343 SGTC_1740 st038286 13.222 µM -1.13064386488542 0.120954477524894 no 2965 0.129102508557146 937 716786 SGTC_1834 st055981 52.8 µM -1.13290736439427 0.120467762597674 no 2966 0.128626578523302 967 471719 YDL150W RPC53 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.13709726805493 0.119570460751613 no 2967 0.127748812939915 941 688667 SGTC_976 1348-1067 47.6 µM -1.13757645787846 0.119468139584219 no 2968 0.127648690813012 955 5310671 YGL099W LSG1 SGTC_616 4092-0450 108 µM -1.13823141274404 0.119328387336963 no 2969 0.127511932515658 977 787165 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.1385471843711 0.119261050197329 no 2970 0.127446034019339 938 1241132 A phosphatase inhibitor. SGTC_1290 0986-0249 10.2 µM -1.13959544318533 0.119037705159559 no 2971 0.12722744233248 966 53329 SGTC_528 3492-0019 172 µM -1.14037319323376 0.118872186451452 no 2972 0.127065428041137 954 2869262 SGTC_901 1112-0062 60.1 µM -1.14209855172191 0.118505580667321 no 2973 0.126706528696154 938 1908457 SGTC_1889 st059080 5.18 µM -1.14228851899174 0.11846526513024 no 2974 0.126667055959416 964 176925 Isolated from Daphnopsis sellowiana. SGTC_660 4031-1742 102 µM -1.14414427786919 0.118071939149445 no 2975 0.126281903739034 929 6738706 SGTC_1646 st011709 75.6 µM -1.14475763981332 0.11794214110626 no 2976 0.126154783591613 970 5757843 SGTC_386 1509-0011 3.07 µM -1.14737464020283 0.117389472617453 no 2977 0.12561340880305 964 3107280 SGTC_212 3807-4682 38.772 µM -1.14880167120648 0.117088880417215 no 2978 0.125318885057218 963 3125501 YBL034C STU1 SGTC_1384 3089-0840 101 µM -1.14980436840032 0.116877997087096 no 2979 0.125112227810797 949 1069836 SGTC_3292 9120825 59.784 µM -1.15006672415078 0.116822863919666 no 2980 0.125058195241691 949 24824900 SGTC_1994 st072947 40.9 µM -1.15089139396011 0.116649682427584 no 2981 0.124888459372456 976 5286565 YDL195W SEC31 SGTC_1452 4194-0072 190 µM -1.15109438984504 0.116607081021751 no 2982 0.124846702883793 962 1343545 SGTC_1451 4152-0210 104 µM -1.15185508610263 0.116447536864499 no 2983 0.124690313557299 983 659563 SGTC_1282 0886-0010 32.4 µM -1.15378579468452 0.116043296316674 no 2984 0.124293999730469 942 2836211 YNL267W PIK1 SGTC_104 0074-0074 590.992 µM -1.15426162722705 0.115943822450163 no 2985 0.124196461725352 965 3943124 SGTC_1668 st014914 51.6 µM -1.15818418935786 0.11512610813219 no 2986 0.123394439515955 981 2839556 SGTC_1851 st056236 18.9 µM -1.15904211633145 0.114947808788499 no 2987 0.123219509105233 933 5393171 SGTC_903 1134-0042 114 µM -1.15913583843093 0.114928342826051 no 2988 0.123200409802024 945 701009 SGTC_382 3229-0966 23.2 µM -1.16003204972736 0.114742319267332 no 2989 0.123017878765132 980 5722370 SGTC_3143 9086658 49.47 µM -1.16255160858744 0.114220490967533 no 2990 0.12250573708159 944 25236626 SGTC_84 0443-0269 128.823 µM -1.16595089013192 0.113519143922906 no 2991 0.121817150867877 925 6150058 SGTC_2478 5763493 32.33 µM -1.16598998023302 0.113511096668347 no 2992 0.12180924830434 955 1365576 YLR208W SEC13 SGTC_3037 9091026 49.47 µM -1.16771792144021 0.11315578166283 no 2993 0.121460282698881 961 25236398 YIL048W NEO1 SGTC_3264 9137442 49.47 µM -1.16956879812011 0.112776068599746 no 2994 0.121087269966298 953 17015726 SGTC_2645 abamectin 100 µM -1.17185175361328 0.11230896748896 no 2995 0.120628290063794 913 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2072 5231554 129 µM -1.17245360983177 0.112186056088413 no 2996 0.120507493348377 963 789545 SGTC_1016 4226-1401 38 µM -1.17281338587752 0.112112628360783 no 2997 0.120435324495558 967 2901613 SGTC_570 0987-0065 62.6 µM -1.17380621067112 0.111910178122642 no 2998 0.12023632789382 918 3104428 SGTC_1529 apigenin 74 µM -1.17754755193565 0.111149617720502 no 2999 0.119488514795574 969 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2746 daunorubicin 9.88 µM -1.17847557152014 0.110961539036293 no 3000 0.11930353276331 947 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_329 k048-0121 21.3 µM -1.18079545702287 0.110492372946132 no 3001 0.118841994624038 979 6832902 SGTC_1711 st032263 62.8 µM -1.18156897008881 0.110336256767985 no 3002 0.118688385944324 974 3958979 SGTC_3110 9122132 49.47 µM -1.1860904468782 0.109426862693826 no 3003 0.117793291388019 977 918317 SGTC_1120 ficusin 1.78878 µM -1.18697403503568 0.109249779281023 no 3004 0.117618931206309 979 6199 A DNA cross-linker. SGTC_590 k048-0076 22.4 µM -1.18821338745339 0.109001742808247 no 3005 0.117374675327375 986 6832814 SGTC_1504 k297-0033 30 µM -1.19073114831981 0.108499100377831 no 3006 0.116879572893253 919 4388117 SGTC_298 1391-0729 10 µM -1.19263863810587 0.10811940341194 no 3007 0.116505463407716 979 3237558 SGTC_128 0906-2981 13.371 µM -1.19464021274558 0.107722007816916 no 3008 0.116113815411178 972 6740226 SGTC_2071 5230951 39.92 µM -1.1953522535166 0.107580892244364 no 3009 0.115974716030067 979 1799272 SGTC_2739 tacrine 100.86 µM -1.19551098963917 0.107549451343074 no 3010 0.115943722567312 914 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_635 k038-0028 24.7 µM -1.1987833076679 0.106902777195069 no 3011 0.115306107408279 987 4035102 SGTC_204 PMA1.184 62.41 µM -1.20186153815015 0.106297023500989 no 3012 0.114708589130678 979 2252213 YGL008C PMA1 SGTC_1694 st024011 44.9 µM -1.20193614803802 0.106282372128422 no 3013 0.114694133932346 981 2787533 SGTC_2451 5856223 45.7 µM -1.20226346063991 0.106218113983021 no 3014 0.114630734482599 968 2179896 SGTC_445 e6 berbamine 66 µM -1.20502450174943 0.105677181782304 no 3015 0.114096921640918 966 6610268 A calcium/calmodulin antagonist. SGTC_1788 fluconazole 20 µM -1.20804756165983 0.105087203231414 no 3016 0.113514484157425 961 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1216 1165-0504 9.65 µM -1.20870866684297 0.104958500619141 no 3017 0.113387395415703 992 6304004 SGTC_85 0868-0259 160.055 µM -1.21013839837382 0.104680553702977 no 3018 0.113112895533846 951 83173 SGTC_767 0929-0023 86 µM -1.21354036930106 0.10402133789524 no 3019 0.112461644895164 978 1204563 SGTC_1772 st048439 82.2 µM -1.21581345737004 0.10358255182094 no 3020 0.112027995598139 955 2927068 YDL195W SEC31 SGTC_3180 9109287 49.47 µM -1.21873580255619 0.10302041170891 no 3021 0.111472242240367 952 18891271 SGTC_2215 7188065 200 µM -1.22065222731032 0.102652974788632 no 3022 0.111108861404726 987 940217 SGTC_1249 0481-0015 10.2 µM -1.2252914642227 0.101767437973235 no 3023 0.110232711660981 962 4227577 SGTC_837 0091-0265 12.5 µM -1.22560684985125 0.101707439719475 no 3024 0.110173329446718 985 759367 SGTC_3111 9122088 49.47 µM -1.22613932239582 0.101606201789539 no 3025 0.110073125217266 952 16876704 SGTC_2796 7949634 45.45 µM -1.2263540786032 0.101565391398069 no 3026 0.110032729472652 970 2971588 SGTC_2190 6049624 200 µM -1.22785231742737 0.101281011288915 no 3027 0.109751205961554 956 2265554 SGTC_405 ebelactone b 50 µM -1.22823445960008 0.101208569983829 no 3028 0.10967948314589 970 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1942 st076330 65.2 µM -1.22900022254775 0.101063520729192 no 3029 0.109535861289557 986 24208414 SGTC_1152 3909-8331 15.9 µM -1.23059503974765 0.100761920212988 no 3030 0.109237180677686 968 16001939 SGTC_2299 7976368 114.88 µM -1.23061309681891 0.100758509149785 no 3031 0.109233802266122 982 2979718 SGTC_1230 0170-0365 3.77 µM -1.23156574691676 0.100578668595439 no 3032 0.109055671382451 941 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1962 st076595 64.5 µM -1.23761818690837 0.099441561012853 no 3033 0.107928833811321 975 279619 SGTC_2305 7443522 69.23 µM -1.23867478250863 0.0992440193978293 no 3034 0.107732980600657 954 5415886 SGTC_272 doxorubicin 8.13 µM -1.23940959728991 0.0991068073431989 no 3035 0.107596924517912 990 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1248 0469-0687 58.6 µM -1.24245978757398 0.0985387281608203 no 3036 0.107033484165146 976 4017482 SGTC_2569 tetrandrine 100 µM -1.24598234355948 0.0978856443244346 no 3037 0.106385438699131 974 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2843 9000894 45.46 µM -1.24642070301707 0.0978045947206688 no 3038 0.106304992260357 944 2242070 SGTC_1001 4048-4355 44.4 µM -1.24668239101562 0.0977562338918099 no 3039 0.106256988994964 973 21824233 SGTC_2521 angolensin 13.4 µM -1.24688477653147 0.0977188443860178 no 3040 0.106219874737715 976 821428 A flavenoid. SGTC_2097 5376186 200 µM -1.24910300697382 0.0973097266907654 no 3041 0.105813700484296 982 742755 SGTC_524 r073-0010 27.8 µM -1.24928397183132 0.0972764060958695 no 3042 0.105780614090459 996 2772106 SGTC_1811 st050069 61.5 µM -1.24954740120708 0.0972279164847301 no 3043 0.105732463808313 975 3877702 SGTC_1381 2324-0066 62.1 µM -1.25344234105403 0.0965130410768868 no 3044 0.105022385233253 994 10885928 SGTC_131 0141-0277 33.849 µM -1.25511550230254 0.096207138421805 no 3045 0.104718416815764 1003 1547771 SGTC_2245 6637752 200 µM -1.25511761177029 0.096206753199978 no 3046 0.10471803398477 1001 681890 SGTC_137 0438-0332 85.389 µM -1.25748732660168 0.0957747219302704 no 3047 0.104288612654997 988 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1086 cerivastatin 2.18 µM -1.25880650463778 0.0955348370774032 no 3048 0.104050115161668 964 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3265 9137266 49.47 µM -1.25994863785499 0.0953275041925587 no 3049 0.103843945670919 952 17224265 SGTC_921 1561-0023 372 µM -1.26251082347597 0.0948635928921601 no 3050 0.103382517064477 980 24050882 SGTC_412 gemfibrozil 100 µM -1.26392753470777 0.0946077973111897 no 3051 0.103128018906056 979 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2564 betulinic acid 100 µM -1.2644869947968 0.0945069236456651 no 3052 0.103027642853103 1005 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_801 0866-0028 10.1 µM -1.26456861020917 0.0944922145777477 no 3053 0.103013005681308 981 6849771 SGTC_627 1391-0720 175 µM -1.2656397337613 0.0942993286642667 no 3054 0.102821046905858 999 997839 SGTC_2065 5221596 34.26 µM -1.26656313624256 0.09413327729734 no 3055 0.102655770334036 967 788581 SGTC_1166 k206-0078 225 µM -1.27095428341273 0.0933465881374208 no 3056 0.101872456511215 978 5404595 SGTC_492 tmb-8 126 µM -1.27286343107257 0.0930060767136777 no 3057 0.101533253880311 979 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1478 0453-0656 35.7 µM -1.27831804631411 0.0920382637660419 no 3058 0.100568653655654 1018 5258496 SGTC_105 0111-0055 734.78 µM -1.28091234248847 0.0915805829117639 no 3059 0.100112228534823 995 5179370 SGTC_836 0330-0104 1.35 µM -1.28269954458841 0.0912662706260575 no 3060 0.0997986797638609 953 46494820 SGTC_1129 3453-1384 223 µM -1.28329138550528 0.0911623610292053 no 3061 0.0996950047985203 995 1084452 SGTC_2868 9035608 32.47 µM -1.28347852974986 0.0911295223501702 no 3062 0.0996622384288679 991 6462614 SGTC_957 1187-1561 14.1 µM -1.28349476537665 0.0911266738568332 no 3063 0.0996593961660778 976 1538454 SGTC_2457 5731572 11.68 µM -1.28499838650777 0.0908631540674585 no 3064 0.0993964239302734 977 2865357 SGTC_3164 9100705 49.47 µM -1.2872048303516 0.0904774840443995 no 3065 0.0990114520459391 968 17174235 SGTC_571 k831-0106 44.2 µM -1.28869619728751 0.0902174933995404 no 3066 0.0987518625166865 975 4783639 SGTC_1074 carmofur 3.8 µM -1.29139886825911 0.0897477503410874 no 3067 0.0982827014373178 994 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2001 4023502 57.655 µM -1.29477891488291 0.0891628366382615 no 3068 0.0976982538368739 976 108941 YCR052W RSC6 SGTC_802 4112-3352 742 µM -1.29504160315835 0.0891174977719345 no 3069 0.0976529390570834 985 704594 SGTC_529 4076-0302 30.3 µM -1.29979942295064 0.0882992856531967 no 3070 0.0968348616736473 997 5816522 SGTC_2202 7226349 200 µM -1.30714336668468 0.0870473424446086 no 3071 0.0955820126322326 994 844334 SGTC_3056 9094900 49.47 µM -1.30719558588229 0.0870384882062893 no 3072 0.0955731471472598 1000 25236784 SGTC_2 0422-0095 29 µM -1.3081597976483 0.0868751182244235 no 3073 0.0954095573650465 968 6790840 SGTC_171 k064-0041 9.68 µM -1.31207582000589 0.0862139662582368 no 3074 0.0947472767863852 972 53325 SGTC_1337 1486-1011 40.3 µM -1.31768624832709 0.0852733119993345 no 3075 0.0938043499430518 996 X1337 SGTC_1607 st000305 50.6 µM -1.31779579613222 0.0852550218630243 no 3076 0.0937860077910929 994 5457690 SGTC_275 trichlorophene 5.69 µM -1.32019086890466 0.0848558740150205 no 3077 0.0933856499169274 969 62616 SGTC_3007 9078383 71.4286 µM -1.32051298213643 0.0848022997008584 no 3078 0.0933319022638928 999 6496995 SGTC_2671 danthron 100 µM -1.32337851978685 0.0843268154572001 no 3079 0.0928547657171525 1005 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2415 st077333 57.7 µM -1.32521478809614 0.0840231734095409 no 3080 0.0925499609520172 974 2766255 SGTC_299 1273-0059 1.44 µM -1.32618380169987 0.0838632703194793 no 3081 0.0923894116879154 961 2848077 SGTC_1411 3909-8223 150 µM -1.32964253167957 0.0832943868507789 no 3082 0.0918180388795451 1005 X1411 SGTC_217 ketoconazole 989 nM -1.33304912219327 0.082736919819136 no 3083 0.0912578420487106 934 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_526 4469-0568 170 µM -1.3338728057535 0.0826025516582602 no 3084 0.0911227726319009 987 2901964 SGTC_34 0469-0683 81.75 µM -1.33399215811505 0.0825830952436888 no 3085 0.0911032132771973 993 3690923 SGTC_1112 tnp00069 1.16933 µM -1.33482761302428 0.0824469988094255 no 3086 0.0909663868734901 994 145826 SGTC_1448 4255-0083 152 µM -1.3389326782446 0.0817807319774499 no 3087 0.0902962951073168 1012 5399660 SGTC_1317 1273-0028 910 nM -1.34725968216441 0.0804417071204468 no 3088 0.0889483061336044 979 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3087 9117406 49.47 µM -1.34811566178872 0.0803050056032322 no 3089 0.0888105924141633 989 42546093 SGTC_1 0258-0098 57.368 µM -1.35113716480432 0.0798238694067105 no 3090 0.0883257491241261 963 6790032 YDR047W HEM12 SGTC_3191 9110352 49.47 µM -1.3533091168071 0.0794793626278154 no 3091 0.087978448936142 981 17122424 SGTC_3039 9090270 49.47 µM -1.3552815689646 0.079167475752869 no 3092 0.0876639324604198 983 17173750 SGTC_106 0092-0003 11.579 µM -1.35564298852306 0.0791104281860133 no 3093 0.0876063935183424 994 1072148 SGTC_2113 5491891 107.031 µM -1.35615615240894 0.0790294823169407 no 3094 0.0875247448987227 989 789979 SGTC_2485 5633444 17.78 µM -1.36348911665862 0.0778796317147095 no 3095 0.086364206070466 992 5724239 SGTC_2055 5235184 200 µM -1.36750515486764 0.0772552982606644 no 3096 0.0857335113079145 999 2836034 SGTC_2353 9059630 146.67 µM -1.36851896660961 0.0770982937735277 no 3097 0.0855748446495784 1012 4779114 SGTC_1470 k295-0292 231 µM -1.38005107563456 0.0753293954344628 no 3098 0.0837854596856852 1030 5045612 SGTC_2882 9058044 58.44 µM -1.38519862502125 0.0745498763843841 no 3099 0.0829958705189419 984 18076804 SGTC_2386 9075165 157.42 µM -1.38528264183951 0.074537204562311 no 3100 0.0829830296540277 1004 16452277 SGTC_931 2812-0076 566 µM -1.385760784091 0.0744651201413338 no 3101 0.0829099803542599 1012 3450959 SGTC_331 k048-0133 24.5 µM -1.38743525384906 0.0742130976460601 no 3102 0.082654540654437 1007 6813582 SGTC_3019 9081971 49.47 µM -1.39009169630299 0.0738146168111932 no 3103 0.0822505172418258 1008 16451803 SGTC_2726 cimetidine 79.27 µM -1.39353359240097 0.073300748235847 no 3104 0.0817292470546907 1009 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1356 1502-0781 85.8 µM -1.39360116542705 0.0732906871711741 no 3105 0.0817190382012511 999 567702 SGTC_1363 1636-0063 10.4 µM -1.39936945496012 0.072435724731779 no 3106 0.0808511108213567 1000 6072185 SGTC_3344 9148862 3.898 µM -1.40242341277477 0.0719861786044782 no 3107 0.0803944229767354 1025 4905352 SGTC_525 k781-2675 26.7 µM -1.40417193366671 0.0717297590292767 no 3108 0.0801338286445501 976 3651118 YDL195W SEC31 SGTC_1202 1988-0068 29.6 µM -1.40697266325756 0.0713204943603864 no 3109 0.0797177475113616 999 2850480 SGTC_2276 7947513 42.08 µM -1.41410928238549 0.0702857392720205 no 3110 0.0786649090623698 1020 2105100 SGTC_2695 st077686 51.995 µM -1.41542979454413 0.070095547226081 no 3111 0.0784712595175592 1004 2876092 SGTC_1861 st057647 17.4 µM -1.41653789423711 0.0699362544490612 no 3112 0.0783090387397683 1008 688668 SGTC_96 0929-0093 37.281 µM -1.41659319667096 0.069928311855946 no 3113 0.0783009493814182 1010 6991579 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.42429207169442 0.0688293512132593 no 3114 0.0771809708027659 986 2346 DNA damaging agent; causes G2/M arrest. SGTC_458 nppb 133 µM -1.4278844540139 0.0683211417527813 no 3115 0.0766625594647033 1023 4549 A chloride channel blocker. SGTC_2282 7944268 200 µM -1.43025032405529 0.0679880300146914 no 3116 0.0763225933247991 1013 2970414 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.43221524596866 0.0677123257333506 no 3117 0.0760411149065198 997 5024745 SGTC_1263 0774-1208 64.8 µM -1.43352954459819 0.0675283950092413 no 3118 0.0758532809555987 1017 906585 SGTC_35 0133-0054 64.071 µM -1.43782963465503 0.0669293122352377 no 3119 0.0752411993676585 1004 99677 SGTC_248 streptozotocin 5.23457 mM -1.43783464920046 0.066928616023394 no 3120 0.0752404877940362 1010 5300 DNA alkylating agent. SGTC_3246 9135460 32.98 µM -1.43946102750997 0.0667031075569217 no 3121 0.0750099721548705 1011 41446951 SGTC_2111 5486399 200 µM -1.44195251840599 0.0663587862435973 no 3122 0.0746578844500869 994 689674 SGTC_1982 st072467 71.9 µM -1.44282557176395 0.066238457396803 no 3123 0.0745348068444411 1008 3163533 SGTC_3107 9121808 49.47 µM -1.44331268703902 0.0661713940703048 no 3124 0.0744662037240192 955 662681 SGTC_3156 9099931 49.47 µM -1.44710921398684 0.0656505102863257 no 3125 0.0739331689087161 1020 18111053 SGTC_3144 9087057 49.47 µM -1.45181836427648 0.0650088381568221 no 3126 0.0732760581339595 998 17249618 SGTC_1798 st045719 60.953 µM -1.45392123358534 0.0647238766665108 no 3127 0.0729840725667098 984 3980186 SGTC_3254 9136651 49.47 µM -1.45459176959311 0.0646332160569689 no 3128 0.0728911554473969 1038 16454030 SGTC_1465 k213-0056 144 µM -1.45669662330824 0.064349267513651 no 3129 0.072600071149209 979 24048857 YMR208W ERG12 SGTC_816 0325-0417 81.3 µM -1.45878784458313 0.0640681189352715 no 3130 0.0723117546080459 1005 68101 SGTC_236 1509-0011 5.31 µM -1.46065311706336 0.0638181540866664 no 3131 0.0720553306622406 1022 3107280 SGTC_3251 9135047 49.47 µM -1.46102506494997 0.0637684002470433 no 3132 0.0720042814658373 1026 17682963 SGTC_2189 6047310 154.431 µM -1.4692970445254 0.0626696734229733 no 3133 0.0708761190520444 1017 711535 SGTC_2425 5628681 7.85 µM -1.48228702573346 0.0609741248978526 no 3134 0.0691319695119502 1028 5714958 SGTC_1867 st057372 64 µM -1.4881944146274 0.060215009235696 no 3135 0.0683498149089073 1034 688837 SGTC_677 0929-0063 136 µM -1.492243764456 0.0596989446099167 no 3136 0.067817626571443 1057 1539583 SGTC_693 4161-2696 114 µM -1.49810837959984 0.0589576873349812 no 3137 0.0670525471601486 1027 805759 SGTC_2480 5767542 37.17 µM -1.50185961962372 0.0584873493154282 no 3138 0.0665666835546127 1005 2867358 SGTC_3129 9127257 49.47 µM -1.50872365539044 0.0576343558654992 no 3139 0.0656847088757168 1023 837894 SGTC_2254 7938975 95.19 µM -1.51715112470651 0.0566004892076217 no 3140 0.0646142664603901 1022 2969277 SGTC_978 1416-0512 87.4 µM -1.52286197332833 0.0559082381152578 no 3141 0.0638966206084836 1047 6814003 SGTC_2948 9070189 9.45 µM -1.52510090583787 0.0556386712304677 no 3142 0.0636169656640376 982 6473636 YDL196W YDL196W SGTC_3100 9120536 49.47 µM -1.52577450815335 0.0555577707455043 no 3143 0.0635330156716113 1013 16421196 SGTC_3185 9108267 49.47 µM -1.52587843012649 0.0555452978579415 no 3144 0.0635200717200292 1021 4910486 SGTC_520 3584-0023 682 µM -1.52830803751112 0.0552543218195725 no 3145 0.0632180376350441 1011 1340790 SGTC_633 0437-0093 97.7 µM -1.53028044385469 0.0550189878668815 no 3146 0.0629736633959562 1026 2831118 SGTC_1447 4239-0816 81.9 µM -1.53169005028919 0.0548512891022209 no 3147 0.0627994694196526 1016 1341554 SGTC_1477 0139-0234 16 µM -1.53578497329822 0.0543664131175111 no 3148 0.0622955631746157 1037 620880 SGTC_713 1488-1073 324 µM -1.5376039823259 0.0541521164939302 no 3149 0.0620727365865589 1039 3312542 SGTC_1418 3966-3099 2.4 µM -1.53960930576944 0.0539166455377643 no 3150 0.0618278078888211 1017 740335 SGTC_1906 st060206 94.7 µM -1.54341170808837 0.0534723828011497 no 3151 0.0613654573665792 1008 5133468 SGTC_2853 9015042 58.44 µM -1.54697292365796 0.0530589348671881 no 3152 0.060934887427309 1010 6457456 SGTC_804 1595-0054 20.9 µM -1.5470838532909 0.0530460970491602 no 3153 0.0609215134729227 1034 761523 Stimulates phospholipase C. SGTC_82 0054-0107 293.755 µM -1.54896672393866 0.0528285690929497 no 3154 0.0606948597603393 1032 3104697 SGTC_319 1348-1596 45.5 µM -1.55811757391174 0.0517814310840741 no 3155 0.059602689738865 1022 5380505 SGTC_2823 7987624 58.44 µM -1.55969647850071 0.0516024361521002 no 3156 0.0594158123654462 1032 2239440 SGTC_684 1140-0066 328 µM -1.56046291704404 0.0515157252146981 no 3157 0.0593252633159765 1039 6813534 SGTC_1911 st060208 74.3 µM -1.56539179399672 0.0509608625052054 no 3158 0.0587455356740755 1031 688783 SGTC_3275 9138069 49.47 µM -1.56923423283029 0.0505316127946385 no 3159 0.0582966851702547 1033 17617007 SGTC_2260 7964312 200 µM -1.5711297197795 0.0503209260781973 no 3160 0.0580762602770207 1036 231951 SGTC_2976 9009005 19.48 µM -1.5711969786431 0.0503134630177946 no 3161 0.0580684508379241 1012 2993148 SGTC_2692 st077426 47.7 µM -1.57369592543959 0.0500368039456732 no 3162 0.0577788821397134 1041 25238571 SGTC_789 1309-1135 70.6 µM -1.57447585768859 0.0499507062439981 no 3163 0.0576887393141744 1024 3092424 SGTC_3152 9099253 49.47 µM -1.57557936213842 0.0498290908843533 no 3164 0.0575613877079415 992 25236131 SGTC_1547 harmine 94.2 µM -1.58209678614212 0.0491156261846691 no 3165 0.0568137385992094 1005 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_229 benomyl 22.8748 µM -1.58430820166537 0.0488754040896104 no 3166 0.0565618001513496 1019 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2098 5376439 882.5 nM -1.58817808118518 0.0484572858644807 no 3167 0.0561230380241538 1030 2844116 SGTC_2419 paclitaxel 166.5 µM -1.5889228857334 0.0483771432107504 no 3168 0.0560389018156553 1022 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2644 guaiazulene 100 µM -1.59291921512986 0.0479489379662467 no 3169 0.0555891575335867 1016 3515 A coloring agent. SGTC_3140 9094243 49.47 µM -1.5954578636724 0.0476785021404584 no 3170 0.0553049426797624 1033 19291112 SGTC_681 1642-0006 26.6 µM -1.59637310481719 0.0475813039136326 no 3171 0.05520275859072 1059 4446530 SGTC_300 r073-0011 5.04 µM -1.59786839974212 0.0474228457632601 no 3172 0.0550361340531606 1045 2735780 SGTC_2366 9070441 60.58 µM -1.60063346993727 0.0471309420863775 no 3173 0.0547290622866595 1026 6837235 SGTC_1171 0368-0077 21.4 µM -1.60810858960073 0.0463490130543954 no 3174 0.053905699150996 1034 3239779 SGTC_943 3253-1379 105 µM -1.61080911271726 0.0460691011081264 no 3175 0.0536106671485405 1012 668464 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.61394881393543 0.0457453767405457 no 3176 0.053269264665271 1044 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2651 TUB2.036 5 µM -1.61738400858414 0.0453932822607137 no 3177 0.0528977077145823 1006 15992207 YFL037W TUB2 SGTC_2465 5809242 33.21 µM -1.61840247555353 0.0452893131790231 no 3178 0.052787944432066 1059 2731748 SGTC_2706 st078239 82.5 µM -1.62044462602001 0.0450814196690307 no 3179 0.0525684001150102 1048 15434492 SGTC_1471 k673-0312 37 µM -1.62054014919335 0.0450717141218678 no 3180 0.0525581485277406 1039 24099884 SGTC_1349 flufenamic acid 69 µM -1.62607686208591 0.0445120287461602 no 3181 0.0519666527376474 1039 3371 A non-steroidal anti-inflammatory. SGTC_721 1187-1332 279 µM -1.62617613482038 0.0445020449709878 no 3182 0.0519560957420613 1049 25730 SGTC_2664 lyso-paf C-16 73.48 µM -1.6313059616489 0.0439885930719066 no 3183 0.0514128880379921 1036 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1665 st014639 11.4 µM -1.63446299853563 0.0436749825818858 no 3184 0.0510808347477782 1041 981133 YIL048W NEO1 SGTC_1597 7-benzyloxygramine 47.5 µM -1.63625163385766 0.0434981071239261 no 3185 0.0508934670223048 1015 260807 SGTC_2934 9036370 36.88 µM -1.63725081778388 0.0433995513204906 no 3186 0.0507890363820872 1010 6462800 SGTC_2440 5628896 157.78 µM -1.63838536604943 0.0432878623328341 no 3187 0.0506706649568176 1037 5522048 SGTC_560 2332-1943 155 µM -1.63982543104947 0.0431464315816614 no 3188 0.0505207344514444 1033 21177716 SGTC_2921 7974240 10.71 µM -1.6412645351013 0.0430054683044779 no 3189 0.0503712572765763 1034 2979074 YDR527W RBA50 SGTC_158 k038-0087 26.446 µM -1.64302985568847 0.0428330598481874 no 3190 0.0501883781233006 1015 X158 SGTC_216 k038-0035 28.382 µM -1.64313115798688 0.0428231832221682 no 3191 0.0501778997463925 1040 4444231 YPR107C YTH1 SGTC_1658 st012944 20 µM -1.64711698525529 0.0424360374771879 no 3192 0.0497670012748428 1036 24207260 SGTC_1928 4'-methoxychalcone 40.3 µM -1.64941464951445 0.0422141534156634 no 3193 0.0495313577704235 1032 641818 SGTC_783 0848-0141 92.7 µM -1.65020980861945 0.0421375843855453 no 3194 0.049450015684611 1042 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_348 k064-0012 10.7 µM -1.65195038141965 0.0419703699868556 no 3195 0.0492723331440242 1026 5066323 SGTC_2508 celastrol 40.54 µM -1.65300725533636 0.0418690999700997 no 3196 0.0491646934891665 1003 122724 Celastrol is a natural product and antioxidant. SGTC_2721 ifenprodil 61.44 µM -1.65917787853012 0.0412817721611113 no 3197 0.0485399769234282 1029 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.66521484280201 0.0407136469131346 no 3198 0.0479349503780672 1030 23665772 A membrane-active detergent. SGTC_2624 nerol 100 µM -1.67299612005399 0.0399907454317443 no 3199 0.0471640299260292 1040 637566 A natural product oil. SGTC_2418 pentamidine 31.67 µM -1.67417420415988 0.0398822130013877 no 3200 0.0470481838148742 983 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2468 5987765 72.9 µM -1.67749894538825 0.0395772079183158 no 3201 0.0467224777571991 1043 26772094 SGTC_2623 humulene 100 µM -1.67752945858586 0.0395744175089127 no 3202 0.0467194969509529 1051 6187145 An anti-inflammatory. SGTC_1458 k015-0034 6.33 µM -1.68071068025148 0.0392843739304958 no 3203 0.0464095625380471 1049 3598957 SGTC_966 1300-0360 30.2 µM -1.68231330141308 0.0391389136926257 no 3204 0.046254051584725 994 70588 SGTC_720 r052-1644 49.9 µM -1.6852639692307 0.0388722462256837 no 3205 0.0459688270101677 1044 1422863 YOR257W CDC31 SGTC_2438 5259590 200 µM -1.68647852131843 0.0387629114858019 no 3206 0.0458518343396215 1041 1201127 SGTC_2767 sibutramine 71.45 µM -1.69256766218616 0.038218533506004 no 3207 0.0452688953853955 1043 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_745 0469-0705 296 µM -1.70375242565988 0.0372348490561578 no 3208 0.0442136746570344 1035 3486736 SGTC_703 3875-0075 71.8 µM -1.70474587353554 0.0371484862137283 no 3209 0.044120915116564 1072 2850814 SGTC_1944 st076371 56.9 µM -1.70523316354693 0.0371061847830743 no 3210 0.0440754735927602 1039 24208455 SGTC_2859 9028643 45.46 µM -1.70926574726657 0.0367576268436334 no 3211 0.0437008675265712 1008 17151580 SGTC_278 4092-0821 23.9 µM -1.71261612744138 0.0364700760852536 no 3212 0.0433915921624572 1057 877900 SGTC_602 3130-1533 38.1 µM -1.72522231237665 0.0354045828692166 no 3213 0.0422437080692745 1047 720941 SGTC_2669 eugenol 100 µM -1.72973834075111 0.0350291474828215 no 3214 0.0418385176118095 1042 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2328 6201408 200 µM -1.73393292949944 0.0346833673263116 no 3215 0.0414649921477035 1040 2890418 SGTC_330 1488-0319 80.1 µM -1.73414468763789 0.0346659856762745 no 3216 0.0414462071051787 1031 6846614 SGTC_321 4534-3890 65.3 µM -1.74640524333 0.0336717408183594 no 3217 0.0403702797457544 1042 699746 SGTC_890 0929-0006 47.2 µM -1.75303785104656 0.0331437394418541 no 3218 0.039797755076005 1049 1378169 SGTC_3266 9136860 49.47 µM -1.75452534685955 0.0330262657225823 no 3219 0.0396702653179528 1010 4871271 YPR165W RHO1 SGTC_3094 9117742 49.47 µM -1.75839475376575 0.0327222889106357 no 3220 0.0393401825834989 1052 17149698 SGTC_796 1234-0020 70.7 µM -1.76179335817214 0.0324572043457101 no 3221 0.039052108670038 1032 46495034 SGTC_1030 k029-0042 36.7 µM -1.77021357863434 0.0318080685117118 no 3222 0.0383457840802019 1041 6080581 SGTC_1259 0671-0132 43 µM -1.77357852617425 0.0315516733143337 no 3223 0.0380664461361004 1040 X1259 SGTC_1904 st060225 78 µM -1.77790198050781 0.0312247536497632 no 3224 0.0377099774510088 1029 66595 SGTC_2041 5107442 45.335 µM -1.78645561126609 0.0305862205322887 no 3225 0.0370127591291734 1059 793005 SGTC_2911 7942208 15.64 µM -1.78861934944648 0.0304264214834591 no 3226 0.0368380697506149 1022 1243384 SGTC_174 3553-0389 74.3 µM -1.79404371950813 0.0300288528289712 no 3227 0.0364030954737768 1058 738071 SGTC_2144 5628481 200 µM -1.79745623513864 0.0297809535999639 no 3228 0.0361316100159535 1042 2818399 SGTC_3190 9110366 49.47 µM -1.80613944558536 0.0291578171656691 no 3229 0.0354482803600175 1053 17123768 SGTC_1635 st007035 42.4 µM -1.8064424891479 0.0291362668445492 no 3230 0.0354246248868437 1005 3716403 SGTC_148 3253-0744 288.01 µM -1.80863769315172 0.0289805542027863 no 3231 0.0352536542900929 1034 6893655 SGTC_2266 7929956 200 µM -1.80975793233402 0.0289013590496469 no 3232 0.0351666671128345 1050 2967153 SGTC_3284 9108171 64.8615 µM -1.81700698018088 0.0283932258415953 no 3233 0.0346080222749448 1036 8687505 SGTC_2482 5981709 142.65 µM -1.82124069378401 0.0280999111543344 no 3234 0.0342851385636204 1043 877755 SGTC_29 0299-0004 12.984 µM -1.82190729004025 0.0280539595882111 no 3235 0.0342345269961971 1048 16871 A napthoquinone isolated from Swertia calycina. SGTC_1651 st011928 86.1 µM -1.82350853392887 0.0279438340730299 no 3236 0.0341132028709513 1062 720198 SGTC_3104 9120930 49.47 µM -1.83077583427038 0.0274485414059336 no 3237 0.0335670043552701 1048 17014836 SGTC_1296 1068-0102 11.9 µM -1.83280416366225 0.0273116173805737 no 3238 0.0334158498777268 1056 767053 SGTC_2906 7926292 26.41 µM -1.83284108594179 0.0273091302012652 no 3239 0.033413103570369 1047 2966319 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.83727120658636 0.0270120741407019 no 3240 0.0330849341603552 1057 16486 A toxic proline analog. SGTC_741 4582-0002 126 µM -1.84712054711484 0.0263612934520523 no 3241 0.0323648355954758 1051 2912688 SGTC_2898 9056270 58.44 µM -1.85063795214207 0.0261320845858401 no 3242 0.0321108279765949 1026 19154699 SGTC_273 hydroxyurea 18.1 mM -1.85171145482047 0.0260624634745847 no 3243 0.0320336341255446 1063 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_844 0330-0132 15.3 µM -1.85919642393894 0.0255813317481634 no 3244 0.0314996507644791 1057 2828079 SGTC_1709 st033179 39.1045 µM -1.8633504728139 0.02531753476363 no 3245 0.0312064866458695 1051 573381 SGTC_2441 5730946 39.09 µM -1.86931429917799 0.0249427980068217 no 3246 0.0307895499421017 1048 1774275 SGTC_2448 5185112 27.17 µM -1.87396516060539 0.0246537989490479 no 3247 0.0304676136040517 1050 5718189 SGTC_2646 retinol 96.75 µM -1.8753135817874 0.0245705368899342 no 3248 0.0303747979822977 1042 445354 A vitamin A analog and teratogen. SGTC_431 k089-0097 107 µM -1.88256034943986 0.0241270965981217 no 3249 0.0298799870420602 1001 5499420 SGTC_2842 9000675 19.48 µM -1.88443272683745 0.0240136222695331 no 3250 0.0297532332610688 1050 2989072 SGTC_3012 9080433 71.4286 µM -1.89568155711698 0.0233412942317081 no 3251 0.0290010827467904 1048 17688859 SGTC_3218 9131285 49.47 µM -1.89652026109028 0.0232918069327668 no 3252 0.0289456417116796 1057 17156417 SGTC_2810 7959871 45.46 µM -1.90040110712541 0.0230639678293618 no 3253 0.0286902508722046 1049 2974535 SGTC_2217 6934799 96.0675 µM -1.91226272382915 0.022379192146063 no 3254 0.0279212522316061 1063 675606 SGTC_1183 1254-0324 198 µM -1.92183952136197 0.021838906065731 no 3255 0.0273129768471124 1053 5799357 SGTC_1706 st031321 9.9705 µM -1.92335720178553 0.0217543038598959 no 3256 0.0272176026656995 1060 6103185 SGTC_3068 9116768 49.47 µM -1.93165888003292 0.0212964155802836 no 3257 0.0267008116272533 1055 41904888 SGTC_2497 7-hydroxyflavone 100 µM -1.93550909510747 0.021086835020137 no 3258 0.0264639268314751 1053 5281894 SGTC_1884 5633444 25 µM -1.93780047740573 0.0209629374046911 no 3259 0.0263237847569428 1051 5724239 SGTC_200 k038-0079 37.545 µM -1.95098290716836 0.0202620559627404 no 3260 0.0255295395668802 1075 3436683 SGTC_3049 9092223 49.47 µM -1.96248377306165 0.0196669051538443 no 3261 0.0248530940001529 1060 8623917 SGTC_2446 5162541 200 µM -1.96420726232386 0.0195790089655823 no 3262 0.0247530304820963 1070 1549321 SGTC_3259 9138485 49.47 µM -1.96633436520629 0.0194709890364989 no 3263 0.0246299998329416 1051 17646153 SGTC_2270 7924575 90.91 µM -1.96734331713113 0.0194199290520882 no 3264 0.0245718221720382 1052 1262135 SGTC_1488 4013-0813 75.9 µM -1.97672316431561 0.0189506645383056 no 3265 0.0240364654707235 1063 2910057 SGTC_2002 4023503 131 µM -1.97745723969821 0.0189143499014589 no 3266 0.0239949846809473 1057 4736863 YCR052W RSC6 SGTC_1459 k035-0031 35.7 µM -1.98084405180264 0.0187475702847541 no 3267 0.0238043824687907 1031 3877128 YMR208W ERG12 SGTC_2608 thymoquinone 42.66 µM -1.99502362985088 0.0180628359871254 no 3268 0.0230201513581533 1056 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1102 cgs 12066b 26.1 µM -1.99727597012145 0.0179560566007202 no 3269 0.0228976061313088 1072 6438352 A 5-HT1B full agonist. SGTC_2888 9058547 12.99 µM -1.99776045313521 0.0179331586134961 no 3270 0.0228713183467841 1056 16476514 SGTC_288 1315-0019 35.1 µM -2.00772214469886 0.017467832602327 no 3271 0.0223364130407584 1039 6811474 SGTC_1128 3448-9350 235 µM -2.0078123474601 0.0174636666412269 no 3272 0.0223316181215955 1053 619386 SGTC_2690 usnic acid 100 µM -2.01037714104812 0.0173455676531303 no 3273 0.0221956439796065 1064 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2409 alverine citrate 63.97 µM -2.01980456255542 0.0169173147157714 no 3274 0.0217018318535194 1051 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2950 9072895 21.46 µM -2.02412475065625 0.0167241053223889 no 3275 0.0214786587868097 1043 17332245 SGTC_3090 9117696 49.47 µM -2.0467235201832 0.0157439176107524 no 3276 0.0203426192792863 1062 7923821 SGTC_2499 avocadenofuran 51.48 µM -2.04766422039845 0.0157042075207887 no 3277 0.0202964559972505 1068 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2614 arthonioic acid 13.39 µM -2.06730060156356 0.0148946942685701 no 3278 0.0193529188068799 1055 6710684 SGTC_1008 4106-0037 6 µM -2.07244304678299 0.0146887204971462 no 3279 0.0191120712063745 1074 2905394 SGTC_36 0335-0881 14.2 µM -2.07994084713793 0.0143927992754051 no 3280 0.0187654794157516 1039 23828853 SGTC_753 1322-0200 289 µM -2.09309215035197 0.0138861368727479 no 3281 0.0181704646506287 1078 5403907 SGTC_2907 7721985 69.9 µM -2.09850074724624 0.0136822736955097 no 3282 0.0179304669822197 1068 3267881 SGTC_2558 carylophyllene oxide 100 µM -2.10916530975423 0.0132878565276919 no 3283 0.0174651575613957 1078 6708694 An oxygenated terpenoid and antifungal agent. SGTC_351 caspofungin 25 nM -2.11022837203408 0.0132490840237335 no 3284 0.017419344913202 1067 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2121 5257820 149.641 µM -2.11823543201496 0.0129601747757301 no 3285 0.0170775669151842 1064 791256 SGTC_3136 9095672 49.47 µM -2.12735009224899 0.012637945889521 no 3286 0.0166955027908754 1064 17217380 SGTC_3170 9103054 49.47 µM -2.14239832180617 0.0121211162807286 no 3287 0.016080721413766 1052 16432970 SGTC_244 nsc-207895 1.295 µM -2.14637209210524 0.0119877343043714 no 3288 0.0159216520277677 1065 42640 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.14690949371879 0.0119697941675443 no 3289 0.0159002438312829 1065 115019 SGTC_1699 st031318 29.054 µM -2.15499084177331 0.0117028083261171 no 3290 0.0155812754437341 1063 5340658 SGTC_1140 3229-1848 2.98 µM -2.17554901539602 0.0110468024518195 no 3291 0.0147944996118994 1067 2849525 SGTC_2963 9082507 9 µM -2.18890895600842 0.0106378459492154 no 3292 0.0143017290006631 1074 16459611 SGTC_794 k038-0031 316 µM -2.19111777143617 0.0105715185605929 no 3293 0.0142216355074783 1069 6624242 SGTC_883 0850-0245 24.6 µM -2.19147447422282 0.0105608411728109 no 3294 0.0142087374715958 1070 6823229 YPR165W RHO1 SGTC_1168 k815-0004 80.5 µM -2.19194669487193 0.0105467203759074 no 3295 0.014191677920777 1080 642433 SGTC_3337 9144342 33.5465 µM -2.19205161698998 0.0105435851280955 no 3296 0.0141878898772697 1073 17682949 SGTC_1563 conessine 56.1 µM -2.19207184797547 0.0105429806859122 no 3297 0.0141871595704179 1074 441082 An anti-amoebic, histamine inhibitor. SGTC_2740 felodipine 17.08 µM -2.19277848999007 0.0105218872415641 no 3298 0.0141616712154843 1081 3333 L-type calcium channel blocker SGTC_2086 5274770 176.623 µM -2.1980031058882 0.0103670689689422 no 3299 0.0139744423037445 1068 689278 SGTC_2811 7967822 32.47 µM -2.20485298581812 0.0101671011441329 no 3300 0.0137322062526531 1059 2232244 SGTC_3237 9133362 49.47 µM -2.22877777653805 0.00949483048234426 no 3301 0.0129143471558206 1075 43845137 SGTC_1925 st057770 10.1 µM -2.23515502632806 0.00932232966309243 no 3302 0.012703586444286 1069 5989122 SGTC_3097 9117246 49.47 µM -2.24231261991514 0.00913199246384288 no 3303 0.0124705873473787 1078 16423892 SGTC_1431 4049-0260 9.09 µM -2.24571992961266 0.0090425856131036 no 3304 0.0123609764046259 1079 3854841 SGTC_2812 7970281 58.44 µM -2.25533467321213 0.00879441844397559 no 3305 0.012056164906228 1075 2233435 SGTC_908 3448-7491 47.7 µM -2.27704507245684 0.00825590000080209 no 3306 0.0113917671062953 1035 1203031 SGTC_553 k007-0256 45.7 µM -2.28315272172437 0.00810971945743458 no 3307 0.0112106869572437 1082 6287000 SGTC_1854 st056233 32.9 µM -2.3030005465744 0.00765026933279372 no 3308 0.0106394061706509 1074 5393174 SGTC_2471 5466956 24.79 µM -2.31374204894779 0.00741130335032834 no 3309 0.0103409379403255 1075 724419 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.32486089628243 0.00717089497010653 no 3310 0.0100396997537058 1079 16623 A steroid. SGTC_2313 7726885 200 µM -2.34674247232016 0.00671778767923654 no 3311 0.00946916967530439 1073 726423 SGTC_3124 9127567 49.47 µM -2.35738682995517 0.00650666407049028 no 3312 0.00920203203496504 1072 17592030 SGTC_3076 9116187 49.47 µM -2.36241328780601 0.00640902370869446 no 3313 0.00907819419800706 1073 27241210 SGTC_1572 epiandrosterone 68.9 µM -2.37263524640374 0.00621445017788106 no 3314 0.00883084788603375 1072 441302 A steroid. SGTC_3052 9092717 49.47 µM -2.39147764501582 0.0058694574084604 no 3315 0.00839035292319512 1071 25237534 SGTC_3075 9116269 49.47 µM -2.42281072315271 0.00533326629780409 no 3316 0.00770047432606394 1072 17015205 YNL244C SUI1 SGTC_2604 4'-hydroxychalcone 11.32 µM -2.45197237412225 0.0048738366740327 no 3317 0.00710377846026299 1078 5282362 SGTC_1875 nocodazole 6 µM -2.52812172873937 0.00383605897061307 no 3318 0.00573372923745 1085 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2033 5192550 145 µM -2.53741209966496 0.00372406908107348 no 3319 0.00558377043923587 1078 182073 SGTC_1044 1222-0021 1.78 µM -2.55125523390839 0.00356263433615959 no 3320 0.00536678441795231 1045 4306703 SGTC_1091 telmisartan 47.6 µM -2.59857420977811 0.00305717625708643 no 3321 0.00468059042252497 1086 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2320 7373003 200 µM -2.62644695408304 0.0027906051302213 no 3322 0.00431407198409037 1072 5415828 SGTC_1732 st034308 51.822 µM -2.63227800748955 0.00273756399758854 no 3323 0.00424072148805522 1072 830119 SGTC_1933 st074711 15.9 µM -2.64276406761285 0.00264446419554733 no 3324 0.00411161569213517 1085 17250958 SGTC_1075 aripiprazole 15.2 µM -2.66310523717863 0.00247197876717341 no 3325 0.00387115981898797 1089 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1198 1612-1005 86.7 µM -2.66950737202133 0.0024198353466677 no 3326 0.00379813027817375 1083 6998509 SGTC_1943 st076331 65.2 µM -2.67518437071181 0.00237443262273632 no 3327 0.00373440817709177 1092 24208415 SGTC_995 3931-2021 34.6 µM -2.6874738750011 0.00227877593309908 no 3328 0.00359973669435241 1088 730143 SGTC_173 1273-0061 2.693 µM -2.71788865593761 0.00205686760671496 no 3329 0.00328499716160145 1059 2847414 YPL266W DIM1 SGTC_293 4049-0273 38.5 µM -2.74642882640352 0.0018666641572703 no 3330 0.00301239784165853 1081 1380311 SGTC_3257 9139206 32.98 µM -2.74791811537071 0.00185719249280656 no 3331 0.00299874926674725 1090 4910041 SGTC_2544 sphondin 68.51 µM -2.78920002262545 0.00161142683511068 no 3332 0.00264192101266047 1083 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2105 5350118 200 µM -2.85275776810937 0.00129050938678312 no 3333 0.00216708227106052 1088 2133313 SGTC_347 4534-1311 26.2 µM -2.8533125005515 0.00128798597498759 no 3334 0.0021633025782823 1090 2862016 SGTC_3250 9135583 49.47 µM -2.85902166413639 0.00126227659396968 no 3335 0.00212474881192002 1091 7699353 SGTC_2989 9073649 71.4286 µM -2.86835875196048 0.00122123985936448 no 3336 0.00206303692888347 1079 21367202 SGTC_3224 9130643 49.47 µM -2.86902674539138 0.00121835133070412 no 3337 0.00205868490543478 1089 17644395 SGTC_2561 acetosyringone 100 µM -2.87613256678321 0.00118800913508105 no 3338 0.00201290297760142 1084 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_481 bay k-8644 50 µM -2.92525558572901 0.000996466428449858 yes 3339 0.00172086710101315 1091 2303 A calcium channel antagonist. SGTC_1945 st075991 56.6 µM -2.97910506198471 0.000819355603918698 yes 3340 0.00144545818183989 1091 1084980 SGTC_923 1900-2434 73.3 µM -2.99957543693617 0.000759995071172985 yes 3341 0.00135178082950887 1087 5910570 SGTC_2957 9076800 11.52 µM -3.02890604701419 0.000681824199130059 yes 3342 0.00122720499969453 1081 16459615 SGTC_2694 st077685 81.9 µM -3.15436032117152 0.000424156003450791 yes 3343 0.000804251777903041 1091 2838096 SGTC_172 1112-0046 2.638 µM -3.17659028075182 0.000389252119798386 yes 3344 0.000745086997806329 1092 2802135 YIL048W NEO1 SGTC_2549 cedrol 20.94 µM -3.19488088194803 0.00036255344466273 yes 3345 0.000699442822434439 1094 6708665 A sedative which affects the nervous system. SGTC_1936 st074407 74.3 µM -3.56614717147276 7.92591980265285e-05 yes 3346 0.000181133990216425 1091 809813 SGTC_2458 5808907 16.39 µM -3.61227152433614 6.49351273171555e-05 yes 3347 0.000151763251014777 1091 2731747 SGTC_1629 st005085 44.9 µM -3.63401425376602 5.90639347979932e-05 yes 3348 0.000139522717893352 1089 24207091 SGTC_1926 methyl fluorone black 53.6 µM -3.67144184109591 5.01130656939852e-05 yes 3349 0.000120592983096057 1090 72721 Reacts with homocysteine. SGTC_1253 0550-0034 176 µM -4.08596380762806 7.32880703359911e-06 yes 3350 2.19471103822661e-05 1095 5969915 SGTC_1627 st003713 25.6 µM -4.42877387919128 1.29613231254647e-06 yes 3351 4.73851591720741e-06 1095 16195070 YER133W GLC7 SGTC_1180 1193-0155 285 µM -4.49396952716419 9.18734800969571e-07 yes 3352 3.49538182364588e-06 1095 2921347 SGTC_2917 7979103 53.79 µM -4.56690309181567 6.21689863238331e-07 yes 3353 2.47491351380085e-06 1094 2980565 SGTC_2912 7964298 10.93 µM -4.62695448637718 4.48743232368142e-07 yes 3354 1.8554101052589e-06 1093 2975850 SGTC_2928 9011484 9.79 µM -5.33756229534279 6.99324138990928e-09 yes 3355 4.71022704166956e-08 1094 2994751 SGTC_3062 9077494 49.47 µM -8.8355187007474 2.29954615153695e-21 yes 3356 4.98174323008979e-19 1079 16459633