SGTCid condition conc unit GPA2|YER020W.score GPA2|YER020W.strain.pval GPA2|YER020W.strain.significant GPA2|YER020W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1616 st002734 56.1 µM 6.08489719899843 1.14895672463979e-09 yes 1 5.82830390409311e-10 8 4026101
SGTC_568 1193-0097 7.48 µM 5.4059937253569 5.2597561753484e-08 yes 2 3.22250263250025e-08 74 3646150
SGTC_542 3381-0244 89.3 µM 5.39702830749646 5.51662892864662e-08 yes 3 3.38768508903733e-08 16 1112843
SGTC_384 k007-0144 5.16 µM 5.34014691873815 7.45275363817748e-08 yes 4 4.64356435224315e-08 32 6824886
SGTC_668 1682-0499 62.6 µM 5.31849742008395 8.35034492318277e-08 yes 5 5.23138517493081e-08 5 682214
SGTC_3 0833-0587 95.581 µM 4.96435482492589 5.05030391831924e-07 yes 6 3.44649117716928e-07 14 5382644
SGTC_435 c-PAF 6.7 µM 4.35450227425315 8.5838027727659e-06 yes 7 6.66847980826036e-06 28 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2405 ticlatone 3.52 µM 4.31524105264835 1.01835155618725e-05 yes 8 7.9714418881458e-06 57 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2061 5245884 80.95 µM 4.16427529263317 1.93944065844343e-05 yes 9 1.56171534384688e-05 17 573863
SGTC_1161 k007-0610 110 µM 4.11829751350099 2.3502893616754e-05 yes 10 1.90840866634643e-05 113 5843850
SGTC_886 0866-0150 153 µM 4.11399204071019 2.39272722095521e-05 yes 11 1.94437424339579e-05 20 271463
SGTC_2809 7964133 12.99 µM 4.06031942278288 2.986572631869e-05 yes 12 2.45028130967969e-05 36 1253665
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 4.05845375951221 3.00953662810217e-05 yes 13 2.469935608019e-05 24 1377
SGTC_176 1486-1328 72.834 µM 3.8885732103351 5.96677375054702e-05 yes 14 5.04176275944508e-05 54 22310231
SGTC_127 0180-0333 59.125 µM 3.84215836881948 7.1615231311725e-05 yes 15 6.09785499998038e-05 51 771601
SGTC_2382 9035899 200 µM 3.80483439642339 8.28211453320201e-05 yes 16 7.09495472401865e-05 17 6462679
SGTC_1270 0831-1170 17.3 µM 3.65066311056499 0.000149014052599164 yes 17 0.00013078206903586 15 6764716
SGTC_1912 st060209 90.8 µM 3.58203795286832 0.000192230893677219 yes 18 0.00017046212396656 42 688787
SGTC_2566 crystal violet carbinol 226 nM 3.49903607849064 0.000260116005528351 yes 19 0.000233471697107471 55 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1026 k007-1105 30.6 µM 3.48136801863394 0.000277193866839304 yes 20 0.0002494297803178 120 7066794
SGTC_2050 5263056 171 µM 3.45856048412291 0.000300785121407022 yes 21 0.000271535160275081 67 763468 YGL055W OLE1
SGTC_2311 7694451 200 µM 3.44185317418996 0.000319238080245091 yes 22 0.000288871872067904 38 2163142
SGTC_2411 st077133 39.94 µM 3.42016735004798 0.000344761488328387 yes 23 0.00031291311655795 55 1403142 YNL221C POP1
SGTC_1444 4112-3581 28 µM 3.37723839751682 0.00040097139389118 yes 24 0.000366087810391056 29 2877249
SGTC_117 lucigenin 22.078 µM 3.28042517210825 0.00056034217043111 yes 25 0.00051825377813253 127 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2435 5706476 10.6 µM 3.25866305705544 0.000603434859413087 yes 26 0.00055969264284771 48 5725375
SGTC_41 0478-0632 82.643 µM 3.25633299784515 0.000608225838293228 yes 27 0.000564306507845079 63 3750424
SGTC_2011 4012611 177 µM 3.23693009339551 0.000649507228192046 yes 28 0.000604115028180372 54 2049887
SGTC_887 0885-0007 9.62 µM 3.21302700218971 0.000703915042343924 yes 29 0.000656719703241045 66 5719458
SGTC_891 0929-0073 133 µM 3.18681856272608 0.000768379297313841 yes 30 0.000719234903214415 53 5603632
SGTC_2052 5265182 7.135 µM 3.18153914834129 0.000782005580680048 yes 31 0.00073247361232855 57 1239884
SGTC_1860 st056228 74.6 µM 3.16522587370815 0.00082552891821655 yes 32 0.000774813017171437 46 688679
SGTC_1284 0929-0043 16 µM 3.16511241228622 0.000825839285723399 yes 33 0.000775115230085679 60 1239883
SGTC_1785 bathophenanthroline 24 µM 3.14223706078415 0.000890652687118527 yes 34 0.000838311140096716 92 72812 An iron chelator.
SGTC_797 k781-0471 270 µM 3.13352484712566 0.000916543334840015 yes 35 0.00086360147219646 52 23738129
SGTC_36 0335-0881 14.2 µM 3.11621786001915 0.00097003829667956 yes 36 0.000915934409107115 166 23828853
SGTC_56 0957-0365 83.25 µM 3.10012213026627 0.00102234718368464 no 37 0.000967204311255812 88 6752360
SGTC_2049 5262831 67.185 µM 3.10002641691343 0.00102266583534682 no 38 0.000967516917475707 70 763417
SGTC_1779 st039427 55 µM 3.08862750021427 0.00106127368340845 no 39 0.00100541694469647 68 1124498
SGTC_2403 6032726 181.2 µM 3.08114951057072 0.00108732268391801 no 40 0.00103101540065556 78 2881040
SGTC_1180 1193-0155 285 µM 3.07699587486323 0.0011020434847748 no 41 0.00104549097271946 53 2921347
SGTC_832 4083-0019 164 µM 3.0589118948264 0.00116828734293831 no 42 0.00111071235183265 185 1990758
SGTC_1813 st051246 8.6015 µM 3.0567271816063 0.00117653242330438 no 43 0.00111883919710465 30 5291959
SGTC_2638 epoxomicin 18 µM 3.04674734641236 0.00121487804011425 no 44 0.00115666031631996 66 9915668 A protesome inhibitor.
SGTC_3315 9136395 68.55 µM 3.01818783256064 0.00133101919651294 no 45 0.00127145618902354 40 16876844
SGTC_363 0455-0021 3.06 µM 2.99083046209641 0.00145170079995291 no 46 0.00139109956055994 132 4597466
SGTC_2648 atorvastatin 78.68 µM 2.98464571993795 0.00148033203646657 no 47 0.00141953468751688 51 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1711 st032263 62.8 µM 2.92476376343036 0.00178540046078119 no 48 0.00172358902292053 53 3958979
SGTC_249 wiskostatin 11.211 µM 2.92257517161685 0.00179756314443133 no 49 0.0017357490609505 53 2775510 A n-wasp and actin depolymerizer.
SGTC_3278 9139605 49.47 µM 2.91378860002249 0.0018471551849594 no 50 0.00178535808551373 61 7958859
SGTC_1272 0839-0021 27 µM 2.87867777166483 0.00205798277376674 no 51 0.00199673068237448 71 5027250
SGTC_1503 4585-0012 61.3 µM 2.8619313147629 0.00216603603122525 no 52 0.0021053407329648 66 2922052
SGTC_1969 st069479 40.1 µM 2.85343086450154 0.00222282892119326 no 53 0.0021624968746519 47 3895485
SGTC_1850 st056238 17 µM 2.84825223764504 0.0022580862413411 no 54 0.00219800337793631 76 5393177
SGTC_2318 6029776 164 µM 2.83188482464779 0.00237287569543351 no 55 0.00231372567500588 98 818325
SGTC_2605 digitonin 300 nM 2.81656449019929 0.00248508039087593 no 56 0.00242701483708871 103 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2057 5236571 38.335 µM 2.79770126387242 0.00262981273246557 no 57 0.00257338453210774 111 54684039 YBR257W POP4
SGTC_129 0088-0017 176.636 µM 2.77595428311998 0.00280608990438478 no 58 0.00275199735926104 131 182446
SGTC_2407 paclitaxel 400 µM 2.77081110527896 0.00284930817393792 no 59 0.00279584274488423 103 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3211 9128781 49.47 µM 2.75787236460483 0.00296069981125077 no 60 0.00290894546385075 146 17194361
SGTC_884 0851-0618 334 µM 2.75775886764076 0.00296169405095755 no 61 0.00290995557873619 81 9642473
SGTC_3336 9143619 71.43 µM 2.75648635766729 0.00297286192589445 no 62 0.00292130249426824 77 45595730
SGTC_1129 3453-1384 223 µM 2.75083976707999 0.00302287704435304 no 63 0.00297213557242037 120 1084452
SGTC_373 0844-0104 25.9 µM 2.74050549508388 0.00311638067638944 no 64 0.00306723780957002 138 5375804
SGTC_259 usnic acid 108.925 µM 2.73869183683644 0.00313305652241067 no 65 0.00308420808227326 81 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_394 menadione 8.33 µM 2.73606142810669 0.00315738480064119 no 66 0.00310897088032581 97 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3024 9090631 49.47 µM 2.7266208683718 0.00324610560130461 no 67 0.00319932564703882 44 25236383
SGTC_1849 st056239 19.2 µM 2.7004454245894 0.00350394443011328 no 68 0.00346233485265087 109 5393181
SGTC_2625 euphol 100 µM 2.69722225870774 0.00353693385830232 no 69 0.00349602924697412 119 6708538 A triterpene alcohol.
SGTC_455 paf C-16 10 µM 2.68188986640511 0.00369771222875525 no 70 0.00366037782231103 91 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1282 0886-0010 32.4 µM 2.67380631735545 0.00378509069459912 no 71 0.00374978753864916 103 2836211 YNL267W PIK1
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.67110646822087 0.00381468423888382 no 72 0.00378008315178083 151 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_637 1181-0519 7.26 µM 2.66229141778145 0.00391275710708187 no 73 0.00388053268493718 202 6252091 YGR060W ERG25
SGTC_2980 9014342 25.29 µM 2.65562792006284 0.0039883853975592 no 74 0.0039580451873726 108 2996599
SGTC_453 enantio-paf c16 10 µM 2.64843481062005 0.00407149142911912 no 75 0.0040432721730689 312 13871343 A lipid and platelet activating factor
SGTC_1276 0871-0068 94.2 µM 2.61877309332632 0.00443080052226549 no 76 0.00441233122950277 82 3414906
SGTC_3002 9075603 71.4286 µM 2.61167315911437 0.00452090074253788 no 77 0.00450501733075402 105 20105405
SGTC_3234 9132280 49.47 µM 2.60233474158913 0.00464189748140355 no 78 0.0046295713880752 105 17612295
SGTC_3289 9119912 71.43 µM 2.56981719270955 0.00508608654636174 no 79 0.00508760967034841 101 17014829
SGTC_398 bronopol 33.3 µM 2.55247323712935 0.00533815544690979 no 80 0.00534805633120785 116 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2075 5212009 200 µM 2.53311264284791 0.00563260165282715 no 81 0.00565273080799277 81 780898
SGTC_1488 4013-0813 75.9 µM 2.53114249226472 0.00566335861431337 no 82 0.00568458256640938 61 2910057
SGTC_3043 9092303 49.47 µM 2.50743340331112 0.00604535701246836 no 83 0.00608057478580726 103 25236084
SGTC_1932 st074806 40.9 µM 2.5049943987768 0.00608592101620989 no 84 0.00612266662902864 132 17251235
SGTC_2539 epi(13)torulosol 80 µM 2.50473039460031 0.00609032620343023 no 85 0.00612723820772019 118 6708597
SGTC_2238 6671620 73.2395 µM 2.48670058334375 0.00639793906497833 no 86 0.00644669314786798 116 729941
SGTC_3219 9131112 49.47 µM 2.42743860665801 0.00750807434155746 no 87 0.00760293009580196 130 17612988 YMR079W SEC14
SGTC_2948 9070189 9.45 µM 2.41932399074586 0.00767259392619612 no 88 0.0077746918771318 141 6473636 YDL196W YDL196W
SGTC_589 1227-0070 34.1 µM 2.41505629805457 0.00776038606110907 no 89 0.00786638887606123 113 2841384
SGTC_2248 tofa 1.1 µM 2.41107652788165 0.00784305055606413 no 90 0.00795275532207217 136 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1710 st031758 61.5 µM 2.40298032387944 0.00801361239072411 no 91 0.00813103120010431 99 5394341
SGTC_1012 4112-3522 18 µM 2.39858008119454 0.0081076727361596 no 92 0.00822938857158807 128 3112398
SGTC_2262 9014885 67.46 µM 2.39461563725146 0.00819324683378765 no 93 0.00831889807533407 58 6457424
SGTC_3018 9082602 49.47 µM 2.39091352030683 0.00827387394240845 no 94 0.00840325552155559 140 17332089
SGTC_2981 9013952 38.96 µM 2.37847945832745 0.0085497940288115 no 95 0.0086921027435084 168 2996344
SGTC_405 ebelactone b 50 µM 2.37819788201793 0.00855613477570442 no 96 0.00869874344470472 139 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_233 rapamycin 362 pM 2.36874046946481 0.0087715140703459 no 97 0.00892438661978234 104 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1299 1079-1439 3.74 µM 2.34257753358124 0.00939228503949305 no 98 0.00957552720058041 121 323161
SGTC_456 gingerol 170 µM 2.30551115687578 0.0103374228834713 no 99 0.010568981317114 155 442793 A herb.
SGTC_604 1000-0114 314 µM 2.29873708229702 0.0105188374518004 no 100 0.0107599367375285 151 1572745
SGTC_1186 1319-0216 26 µM 2.28973802173166 0.0107641252929466 no 101 0.0110182539537171 158 4565136
SGTC_1514 1189-1591 158 µM 2.2891501474473 0.0107803208994258 no 102 0.0110353149944176 198 767698 YMR146C TIF34
SGTC_1427 4048-4900 550 nM 2.288701448641 0.0107926965707505 no 103 0.0110483524015933 140 24132586
SGTC_593 1203-0218 61.7 µM 2.27538843138448 0.0111655563797267 no 104 0.011441319371491 139 3666956
SGTC_2119 5528445 120.635 µM 2.27520158364979 0.0111708681763313 no 105 0.0114469199607635 153 791935
SGTC_3284 9108171 64.8615 µM 2.27251671870111 0.011247437759213 no 106 0.0115276596855632 132 8687505
SGTC_1306 1185-0270 9.02 µM 2.26621568075274 0.0114289308587225 no 107 0.0117190905094551 175 1548076
SGTC_2402 5553605 200 µM 2.25669205695464 0.0117080742003706 no 108 0.012013661762796 172 6758546
SGTC_3224 9130643 49.47 µM 2.25538178806243 0.0117469383713545 no 109 0.0120546874389291 181 17644395
SGTC_1553 gossypol 38.6 µM 2.24770945243628 0.0119767638808432 no 110 0.0122973614368674 64 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_897 1000-0139 31.4 µM 2.24618728138809 0.0120228213646538 no 111 0.0123460072766526 134 6151020
SGTC_3302 9125395 16.351 µM 2.22681509217425 0.012622529532158 no 112 0.0129798171553334 150 17599668
SGTC_2367 9070478 135.38 µM 2.21453464826123 0.0130159624175461 no 113 0.0133960109818898 184 572802
SGTC_813 k007-0158 173 µM 2.21085700484384 0.0131358283471566 no 114 0.0135228704219401 209 6523916
SGTC_1269 0831-0796 3.05 µM 2.20210320131804 0.0134249863433548 no 115 0.0138290097042844 160 927758
SGTC_963 1269-2853 151 µM 2.19792186319426 0.0135650341932904 no 116 0.0139773372971192 163 3668223
SGTC_1405 3909-7894 12 µM 2.19152362553175 0.0137817744481906 no 117 0.014206960996883 148 7104060
SGTC_1415 3966-0071 78.1 µM 2.18714718877965 0.0139317408228835 no 118 0.0143658903648329 126 2893185
SGTC_443 clozapine 122 µM 2.18391726917614 0.0140433201630479 no 119 0.0144841639041788 107 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2976 9009005 19.48 µM 2.17325061698082 0.0144172942458591 no 120 0.0148807300154762 165 2993148
SGTC_1167 k781-0610 148 µM 2.17190110074049 0.0144652140502759 no 121 0.0149315617210085 202 4525169
SGTC_265 mycophenolic acid 32.932 µM 2.17097168400907 0.0144982962690301 no 122 0.0149666564453783 191 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1006 4099-6547 255 µM 2.16873467640044 0.0145781887887922 no 123 0.0150514165689186 181 3146833
SGTC_2380 9035439 200 µM 2.14063054306081 0.0156146216960249 no 124 0.0161519218533916 205 6462575
SGTC_1362 1611-0397 101 µM 2.12899736545831 0.0160617874862759 no 125 0.0166272391858553 181 27816
SGTC_2866 9034245 58.44 µM 2.12527398771045 0.0162072089567095 no 126 0.0167818787384296 137 6462273
SGTC_660 4031-1742 102 µM 2.11975289421575 0.0164249182358039 no 127 0.0170134448661318 231 6738706
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.11504692800001 0.0166124571894636 no 128 0.0172129739240807 220 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1448 4255-0083 152 µM 2.11467537945846 0.0166273416284807 no 129 0.0172288120831028 180 5399660
SGTC_1409 3909-8004 61.9 µM 2.10839938286747 0.016880491180962 no 130 0.0174982288924603 223 2119279
SGTC_194 1486-1323 56.904 µM 2.09804298350024 0.0173054350816781 no 131 0.0179506742493491 174 5178754
SGTC_976 1348-1067 47.6 µM 2.08975497427077 0.0176520599128783 no 132 0.0183199079447948 219 5310671 YGL099W LSG1
SGTC_2202 7226349 200 µM 2.0825425276606 0.0179585068643345 no 133 0.0186464712874538 141 844334
SGTC_1191 1487-1166 10.6 µM 2.07346875378926 0.0183504726913483 no 134 0.0190643380649664 225 3955771
SGTC_2964 9083345 53.42 µM 2.07209880631476 0.0184102798718701 no 135 0.0191281138200301 191 17741579
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.06437560205101 0.0187505633648837 no 136 0.0194910589491074 265 91467 include heat shock
SGTC_1286 0929-0070 131 µM 2.0639756476135 0.0187683301295696 no 137 0.0195100126956334 219 1420408
SGTC_2133 5320837 200 µM 2.05990328173666 0.0189500496152848 no 138 0.0197038939618228 196 2841355
SGTC_3183 9108214 49.47 µM 2.04953394357315 0.0194195251106307 no 139 0.0202049661051754 71 4974831
SGTC_2439 5492030 7.2 µM 2.04073696150097 0.0198255240492 no 140 0.0206384896961412 174 5722370
SGTC_2469 5655019 90.81 µM 2.03947227155213 0.0198844802654485 no 141 0.0207014579395059 207 2788239
SGTC_2523 spermine 47.74 µM 2.03741417070054 0.0199807410590579 no 142 0.0208042774947093 191 1103 A DNA binding polyamine.
SGTC_64 000l-0018 272.079 µM 2.03204515653434 0.0202337214327105 no 143 0.0210745423504341 400 6811119
SGTC_1397 3532-0190 20.1 µM 2.02932310839283 0.0203630145671058 no 144 0.0212126955591453 142 5322280
SGTC_956 1185-0240 191 µM 2.0279195643487 0.0204299539400434 no 145 0.0212842290137089 211 1416193
SGTC_465 cgp-37157 41 µM 2.02142293512368 0.020742232616788 no 146 0.0216180012466404 124 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2438 5259590 200 µM 2.02046829606505 0.020788458891066 no 147 0.0216674177435149 200 1201127
SGTC_417 st075190 100 µM 2.01480181986789 0.0210646445279396 no 148 0.0219627091487608 213 222757
SGTC_2970 9090938 41.86 µM 2.00588260964272 0.0215056561697513 no 149 0.0224343870405192 315 17217104
SGTC_1047 2043-3044 82 µM 1.97509068302893 0.0230886008356287 no 150 0.0241289289827272 250 669592
SGTC_2585 alliin 100 µM 1.9679734433092 0.0234681252412201 no 151 0.0245355466987595 255 87310 A garlic compound which reacts with lipids.
SGTC_2707 st078556 66.6 µM 1.96578790456934 0.0235857164687045 no 152 0.0246615577844765 192 17250899
SGTC_583 1488-1091 88.9 µM 1.9650189021394 0.0236272097443348 no 153 0.0247060249203995 277 4303273
SGTC_2835 9006588 71.43 µM 1.96457097276129 0.0236514070752213 no 154 0.0247319571738116 257 2345538
SGTC_175 3793-3120 23.7 µM 1.96429232414509 0.0236664703011485 no 155 0.0247481006686675 222 5322297
SGTC_565 1418-0001 44.5 µM 1.96400989901606 0.0236817459098698 no 156 0.0247644719746498 265 2862145
SGTC_1400 3771-8998 51.5 µM 1.95853617127951 0.0239794464240024 no 157 0.0250835654902195 162 670767
SGTC_2962 9082311 13.18 µM 1.94675427585205 0.024630910480876 no 158 0.0257821005689355 214 16459453
SGTC_1230 0170-0365 3.77 µM 1.93729724599972 0.0251645100265218 no 159 0.0263545093624571 381 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1985 st071382 65.5 µM 1.9330954853501 0.0254046783554172 no 160 0.026612218072929 229 6123237
SGTC_2812 7970281 58.44 µM 1.92431252310826 0.0259129081779409 no 161 0.0271577109000125 281 2233435
SGTC_2886 9058944 51.95 µM 1.92035575914211 0.0261446321318789 no 162 0.0274064888520962 104 4949929
SGTC_2540 epiandrosterone 100 µM 1.91817264921498 0.0262732238872501 no 163 0.0275445615258935 347 441302 A steroid.
SGTC_2268 7933382 153.85 µM 1.91718286495013 0.0263316991321691 no 164 0.0276073520763161 301 935025 YOR257W CDC31
SGTC_1889 st059080 5.18 µM 1.90888462401545 0.0268262411643632 no 165 0.0281384884858008 256 176925 Isolated from Daphnopsis sellowiana.
SGTC_1523 st012844 44.7 µM 1.90672783661374 0.0269560393932849 no 166 0.0282779201685246 253 4274103
SGTC_2077 5212015 200 µM 1.89932640708032 0.0274054595194643 no 167 0.0287607864560872 280 780900
SGTC_3199 9111318 49.47 µM 1.89844279074376 0.0274595284653288 no 168 0.0288188886341647 249 8548020
SGTC_2791 5663188 71.43 µM 1.88277140983468 0.0284333399415971 no 169 0.029865676587071 247 54690634
SGTC_3185 9108267 49.47 µM 1.88031030086219 0.0285888519147353 no 170 0.0300329001206613 277 4910486
SGTC_57 miconazole 162.5 nM 1.87700967228729 0.0287985212420373 no 171 0.0302583841084673 239 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1904 st060225 78 µM 1.87666015242307 0.0288207988297739 no 172 0.0302823436642159 235 66595
SGTC_1966 st070145 16.1 µM 1.87566745866525 0.0288841489744263 no 173 0.0303504784899225 250 3748532
SGTC_584 0986-0246 15.4 µM 1.87432794627924 0.0289698152656513 no 174 0.0304426189726367 258 53315 YDR232W HEM1
SGTC_1420 4'-methoxyflavone 42 µM 1.87100037453862 0.0291835387376898 no 175 0.0306725145523265 226 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_121 0557-0495 61.343 µM 1.85103697918239 0.0304934166466863 no 176 0.0320821166699323 421 3104427
SGTC_199 4063-0024 41.6 µM 1.84672150017169 0.0307828826418214 no 177 0.0323937569985261 222 306215
SGTC_793 0488-0545 106 µM 1.83670846127076 0.0314632892493467 no 178 0.0331264727484488 262 292548
SGTC_613 3914-0030 117 µM 1.83433173326453 0.0316266057396066 no 179 0.0333023831958845 68 1145395
SGTC_2089 5281248 129.67 µM 1.82269384336731 0.0324364462852874 no 180 0.0341748866453811 289 2737878
SGTC_705 1124-0212 310 µM 1.8217128296657 0.0325054865339743 no 181 0.0342492851235184 295 9554485
SGTC_873 0591-4978 488 µM 1.81831158248351 0.0327457935143939 no 182 0.0345082617540292 282 3305145
SGTC_360 0957-0399 1.01 µM 1.81087167688413 0.0332765505463679 no 183 0.0350803588944389 310 6752301 YPR165W RHO1
SGTC_1011 4112-3381 17.4 µM 1.7789663349577 0.0356335841273667 no 184 0.0376226407053981 314 2877139
SGTC_2715 st079500 56.4 µM 1.77730492327168 0.0357599787049871 no 185 0.0377590420346866 249 28246688
SGTC_274 sirtinol 40.1 µM 1.76593753939142 0.036634659150032 no 186 0.0387031641886708 286 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1219 1469-0211 33.1 µM 1.76224872375995 0.0369222337014106 no 187 0.039013641582883 260 6822282
SGTC_139 0099-0334 718.624 µM 1.74948489813346 0.037931554367918 no 188 0.0401036185062985 371 97690
SGTC_2819 7996655 46.38 µM 1.74605930279799 0.0382062376889098 no 189 0.0404003238002813 266 6456960
SGTC_142 0335-0849 62.6745 µM 1.74575113105046 0.0382310279419624 no 190 0.0404271030202134 458 3889043 YPR107C YTH1
SGTC_2650 prasterone 100 µM 1.73914372738224 0.0387657100328675 no 191 0.0410047423725678 187 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1030 k029-0042 36.7 µM 1.72673126996204 0.0397866109167146 no 192 0.042107968507435 356 6080581
SGTC_1937 st074714 47.2 µM 1.72590773981567 0.039855110695059 no 193 0.0421820060401024 322 17250970
SGTC_1717 st033143 58.0435 µM 1.72289527614133 0.0401064992142394 no 194 0.0424537323787995 361 674616
SGTC_425 3825-7017 13.1 µM 1.72191786095961 0.0401883402653149 no 195 0.0425421994909531 357 3397440
SGTC_3075 9116269 49.47 µM 1.71813320443784 0.0405065181408918 no 196 0.0428861607849592 295 17015205 YNL244C SUI1
SGTC_3329 9141233 27.5565 µM 1.71377027530057 0.040875846094225 no 197 0.0432854622781159 290 4909101 YNL103W MET4
SGTC_519 k048-0011 62.8 µM 1.71337470864833 0.0409094659920042 no 198 0.0433218130499197 316 6836379
SGTC_208 k072-0098 12.366 µM 1.7091174890961 0.0412727161167826 no 199 0.0437145943059465 403 5948901
SGTC_2479 5617353 43.85 µM 1.70861027485637 0.0413161682901088 no 200 0.0437615820631019 341 2731746
SGTC_1335 1486-0900 202 µM 1.69595993547356 0.0424119485840915 no 201 0.0449467338715599 365 X1335
SGTC_1878 temozolomide 1 mM 1.68968158920414 0.0429644468390526 no 202 0.0455444436740844 278 5394 DNA alkylating agent.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.68616305973737 0.0432766134705205 no 203 0.045882198393578 216 77254
SGTC_1 0258-0098 57.368 µM 1.68319349086161 0.0435414988286299 no 204 0.0461688202455801 276 6790032 YDR047W HEM12
SGTC_464 bw-b 70c 158 µM 1.6830571932634 0.0435536879054453 no 205 0.046182010084137 379 5353454
SGTC_1473 k844-0725 134 µM 1.66212640229219 0.0454584561856326 no 206 0.0482437163916135 364 54682906
SGTC_648 0375-0473 33.3 µM 1.66013609799567 0.0456430154228573 no 207 0.0484435382099098 381 1713139
SGTC_882 0843-0131 351 µM 1.65966159072834 0.0456871048879684 no 208 0.048491275188507 358 5425421
SGTC_1200 1643-0193 18.4 µM 1.65110385350984 0.0464881503145845 no 209 0.04935868530071 356 5403974
SGTC_2644 guaiazulene 100 µM 1.64498332525241 0.0470679460112723 no 210 0.0499866249094512 303 3515 A coloring agent.
SGTC_339 3091-4833 71.4 µM 1.64484450520572 0.0470811633256916 no 211 0.0500009407841468 305 3240077
SGTC_2771 fluoxetine 41.05 µM 1.64466960806058 0.0470978198437743 no 212 0.0500189817786435 309 3386 A selective serotonin reuptake inhibitor.
SGTC_1897 st060201 15 µM 1.64346923315719 0.0472122663622643 no 213 0.0501429429826355 310 611878
SGTC_2933 9026794 32.47 µM 1.64210986270991 0.0473421409275212 no 214 0.0502836190444571 387 17586027
SGTC_733 4069-0007 56.1 µM 1.63676907043583 0.0478551758455765 no 215 0.0508393653345374 438 5717425 YNL287W SEC21
SGTC_2796 7949634 45.45 µM 1.63584803833858 0.0479440982431454 no 216 0.0509356976245997 362 2971588
SGTC_2524 avocatin b 10.57 µM 1.6352270960766 0.0480041226332175 no 217 0.0510007249796683 314 6710748
SGTC_2104 5389443 200 µM 1.63448012573068 0.0480764094129278 no 218 0.0510790379961621 392 2244536
SGTC_2828 7998861 71.43 µM 1.63431795891162 0.0480921143329194 no 219 0.0510960523427742 277 2988188
SGTC_2502 avocadyne acetate 18.59 µM 1.62966039543035 0.0485449272696667 no 220 0.0515866460795888 431 3952079
SGTC_3251 9135047 49.47 µM 1.62404522793521 0.0490953646973756 no 221 0.0521830781121538 270 17682963
SGTC_205 1486-1330 71.903 µM 1.62379823004315 0.0491196911329574 no 222 0.0522094389734238 281 4118834
SGTC_2237 6667747 47.222 µM 1.62100642613275 0.0493953214318426 no 223 0.0525081302644435 321 729940 YDL015C TSC13
SGTC_2360 9040895 200 µM 1.61872567681082 0.049621411322329 no 224 0.0527531498441065 355 4914414
SGTC_3354 9151612 71.43 µM 1.60664960804554 0.0508323019421458 no 225 0.054065626833697 383 27261949
SGTC_2888 9058547 12.99 µM 1.59053951552134 0.0524841880005599 no 226 0.0558566229266475 287 16476514
SGTC_376 3970-0862 59.1 µM 1.58281319358065 0.0532914021959717 no 227 0.0567320243288161 388 3135186
SGTC_2352 9027995 87.8 µM 1.58001282761985 0.0535863910094892 no 228 0.0570519644285907 311 2997347
SGTC_3178 9107506 49.47 µM 1.57741949948697 0.0538607228401974 no 229 0.0573495157876675 377 8897194
SGTC_918 glabranin 770.725 nM 1.5651306499922 0.0551758332558939 no 230 0.0587761391048956 413 124049 Also referred to as licorice root.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.56254534538439 0.0554557069153883 no 231 0.0590797861055191 450 4114 Related to psoralen; DNA damaging agent.
SGTC_617 3770-0098 35 µM 1.56124976999532 0.0555963811471806 no 232 0.0592324150487928 365 5962639
SGTC_2658 polymyxin b sulfate 77.05 µM 1.56065900457108 0.0556606201871041 no 233 0.0593021144142223 409 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3325 9138760 55.175 µM 1.55980532023239 0.0557535521499938 no 234 0.0594029469227307 387 43844959
SGTC_1875 nocodazole 6 µM 1.5553606521187 0.0562393778371849 no 235 0.0599300998765012 376 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_858 0438-0351 2.77 µM 1.55448020891051 0.0563360098242847 no 236 0.0600349569445701 415 2799119
SGTC_408 cantharidin 100 µM 1.54662768035222 0.0572036541749631 no 237 0.0609765255137999 432 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1840 st055363 71 µM 1.54656641659693 0.0572104644645098 no 238 0.0609839165552522 344 676033
SGTC_292 k038-0015 474 µM 1.53931076050231 0.0580215509374423 no 239 0.06186422411484 368 46368540
SGTC_685 1278-0033 54.9 µM 1.53626086756165 0.0583651747830615 no 240 0.0622372064868119 425 3590572
SGTC_1972 st070201 17.4 µM 1.53508363017814 0.0584982379492665 no 241 0.0623816433803745 383 2829099
SGTC_1686 st019653 115.5 µM 1.52914393455615 0.0591732381490543 no 242 0.0631143829136508 367 97252
SGTC_2401 5128683 200 µM 1.52809361865822 0.0592932314591504 no 243 0.063244647817523 371 708373
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.51973525985849 0.0602549441668043 no 244 0.064288762986872 476 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_695 3505-6186 243 µM 1.51927196353955 0.0603086061094963 no 245 0.0643470268881548 412 1819379
SGTC_1804 st050076 49.1 µM 1.51878097321376 0.0603655165667826 no 246 0.0644088183500959 410 3895976
SGTC_2423 st077119 87.2 µM 1.51461973274289 0.0608495329908819 no 247 0.0649343660325835 407 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_588 3970-1144 52.9 µM 1.51384111261062 0.060940434622091 no 248 0.0650330712597159 431 1888707
SGTC_468 gf-109203x 121 µM 1.5088831125044 0.0615217592579552 no 249 0.0656643280885709 265 2396 A protein kinase C inhibitor.
SGTC_575 k072-0246 11.9 µM 1.50639204757384 0.0618154662521856 no 250 0.0659832804774694 424 6796779
SGTC_1316 1272-0050 65.9 µM 1.50355310864819 0.0621515222356437 no 251 0.0663482362973245 394 7340392
SGTC_2576 guaiol 23.12 µM 1.50346682646379 0.062161758057706 no 252 0.066359352608385 446 227829
SGTC_2742 clothiapine 36.27 µM 1.49761464479791 0.0628590880944394 no 253 0.0671166998139826 345 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1764 st044502 93.5 µM 1.49458404472114 0.0632225937357617 no 254 0.067511516369267 438 8407
SGTC_898 1000-0849 28.3 µM 1.49398992156396 0.0632940474129564 no 255 0.0675891267603639 415 6751807
SGTC_1374 2889-5571 141 µM 1.48899623799258 0.0638971125151323 no 256 0.0682441796911347 486 2853281
SGTC_649 1123-0311 367 µM 1.48735842432985 0.0640958742319459 no 257 0.0684600857103973 489 693629 YIL048W NEO1
SGTC_2034 5197015 53.07 µM 1.48652689090921 0.0641969712302683 no 258 0.0685699047327101 433 780676
SGTC_490 phenamil 164 µM 1.47525189134767 0.0655800398638106 no 259 0.0700724175803488 308 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2270 7924575 90.91 µM 1.4679005640189 0.06649417400932 no 260 0.0710656174865481 459 1262135
SGTC_2616 abietic acid 100 µM 1.46408821211445 0.0669721066221929 no 261 0.0715849238294994 469 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1679 SEC14.276 6.7 µM 1.46372771043378 0.06701743780202 no 262 0.0716341805015823 518 1005053 YMR079W SEC14
SGTC_1103 duloxetine 36.1 µM 1.4619286631433 0.0672440132874209 no 263 0.071880379707695 496 60835 A selective serotonin reuptake inhibitor.
SGTC_2358 9037157 4 µM 1.45963068285359 0.06753428618235 no 264 0.0721958009337103 443 2388925
SGTC_671 0560-0003 407 µM 1.45158805060099 0.0685578322478677 no 265 0.0733080916443404 431 3238678
SGTC_2505 galangin 7.89 µM 1.45140365664486 0.068581438697442 no 266 0.0733337460648552 369 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_763 3453-1109 128 µM 1.45068819709425 0.0686730924903456 no 267 0.0734333517670385 453 1560353
SGTC_60 0986-0278 202 µM 1.44804414329374 0.0690126282019313 no 268 0.0738023527060094 326 3110598
SGTC_924 2046-0044 21.3 µM 1.44740484528581 0.0690949174629365 no 269 0.0738917847535476 443 3623589
SGTC_1014 4130-3005 69.3 µM 1.4438027785341 0.0695599828073127 no 270 0.0743972301040615 482 743608
SGTC_1604 st002052 72.4 µM 1.44248939379704 0.0697301531812702 no 271 0.0745821807636094 457 6254834 YHR062C RPP1
SGTC_2870 9038528 12.99 µM 1.43932656870474 0.0701412635810632 no 272 0.0750290093001608 412 6463316
SGTC_90 0870-0863 4.608 µM 1.43620477999724 0.0705488657601956 no 273 0.0754720396392288 505 1738164
SGTC_910 3454-3003 490 µM 1.43450457582953 0.0707716206042181 no 274 0.0757141621135271 485 820824
SGTC_2913 7966556 36.57 µM 1.43400497269599 0.0708371794967786 no 275 0.0757854218989772 416 2976516
SGTC_2994 9053520 71.4286 µM 1.43097123278048 0.0712362750140752 no 276 0.0762192299775043 461 4647384
SGTC_1718 roemerine 11.9335 µM 1.42956241632489 0.0714221940295474 no 277 0.0764213244343487 529 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1151 3909-8316 15.3 µM 1.42954769234531 0.0714241390916011 no 278 0.0764234387370555 468 800431
SGTC_619 1652-1634 108 µM 1.42624939480881 0.0718608750490985 no 279 0.0768981831250427 425 5400454
SGTC_1089 terbinafine 2.25 µM 1.42486601329186 0.0720446605760137 no 280 0.0770979678318525 439 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.42317293210773 0.0722700805769884 no 281 0.0773430151173738 516 4174840
SGTC_969 1313-0238 134 µM 1.42308867335751 0.0722813130480218 no 282 0.0773552257030061 517 5212874
SGTC_301 4119-0100 24.5 µM 1.42219390815392 0.0724006760799494 no 283 0.0774849833843458 524 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.41895536491468 0.0728339654206627 no 284 0.0779560147346036 425 616764
SGTC_646 4092-0839 27.3 µM 1.41805917808999 0.0729542175389314 no 285 0.0780867440593032 464 877796
SGTC_1250 0485-0349 40.2 µM 1.41753524214679 0.073024590658787 no 286 0.0781632490858285 481 6842794 YDL195W SEC31
SGTC_262 fenpropimorph 62.5 µM 1.41376020765523 0.0735331758144157 no 287 0.0787161604024905 412 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1096 rimcazole 32.2 µM 1.41100258243987 0.0739064008970842 no 288 0.0791219262806862 427 18528119 A dopamine reuptake inhibitor.
SGTC_1375 2910-0797 186 µM 1.41028675214534 0.0740035197215553 no 289 0.0792275143536325 473 742508
SGTC_601 0986-0029 62.9 µM 1.41015893462973 0.074020871359046 no 290 0.079246379211531 520 24747981
SGTC_98 0074-0023 107.663 µM 1.40913526680262 0.0741599496993042 no 291 0.0793975872158566 509 3563821
SGTC_3164 9100705 49.47 µM 1.40236077956006 0.0750853863183821 no 292 0.0804037695090119 393 17174235
SGTC_3039 9090270 49.47 µM 1.39656110916084 0.0758846317310223 no 293 0.08127279608749 433 17173750
SGTC_752 1896-0090 130 µM 1.39105495848368 0.0766494071885577 no 294 0.0821043808987965 490 772567
SGTC_2741 miltefosine 3.04 µM 1.38687585557509 0.077233764860731 no 295 0.0827398106727588 392 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1977 st070720 65.3 µM 1.38117120665126 0.078036892769263 no 296 0.0836131628308638 448 682188
SGTC_998 3996-0085 177 µM 1.37933831598502 0.0782962763017837 no 297 0.0838952340499599 542 715391
SGTC_1673 st016611 27.3 µM 1.37806215090831 0.0784772599253474 no 298 0.0840920500312501 515 5226799
SGTC_2687 chenodiol 100 µM 1.37544096811177 0.0788499861775199 no 299 0.0844973876063858 473 5702181 A cholesterol synthesis inhibitor.
SGTC_1935 st074532 41.6 µM 1.37273506184717 0.079236165210527 no 300 0.0849173625156237 579 2829742
SGTC_1485 3909-9022 254 µM 1.37265885623829 0.0792470617470244 no 301 0.0849292127549496 511 714516
SGTC_319 1348-1596 45.5 µM 1.36972791635138 0.0796670142929682 no 302 0.0853859254703056 516 5380505
SGTC_1135 dihydrocapsaicin 536.708 nM 1.36886949641971 0.0797903290943609 no 303 0.0855200361504981 514 107982 A Capsaicinoid.
SGTC_2068 5226020 147 µM 1.36197005701612 0.0807867044047588 no 304 0.0866036674985209 561 1810509
SGTC_1757 st041620 31.8375 µM 1.3566324566 0.0815639518218787 no 305 0.0874490117904025 504 5289815
SGTC_642 0335-0876 158 µM 1.3553529320163 0.0817511079859127 no 306 0.087652569041896 511 6812350
SGTC_1338 1486-1223 76 µM 1.35145085131326 0.0823238645887656 no 307 0.0882755268904736 548 3444526
SGTC_1564 D-Arginine 115 µM 1.35123948960014 0.0823549748151497 no 308 0.0883093642508765 505 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_361 000s-0510 1.45 µM 1.35056300641445 0.0824546055523962 no 309 0.0884177289068615 523 660
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.34646980110957 0.0830593790159909 no 310 0.0890755266006554 539 688801
SGTC_938 3126-1755 342 µM 1.34114762007883 0.0838507155591951 no 311 0.0899362644269854 547 1777771
SGTC_1432 4049-0298 68.4 µM 1.34085997587882 0.0838936451071108 no 312 0.0899829595709759 494 741646
SGTC_1708 st033234 31.827 µM 1.33832597298346 0.0842725466047491 no 313 0.090395099330627 557 674664
SGTC_1900 st060200 72.8 µM 1.33760704667882 0.0843802789244826 no 314 0.0905122830727621 516 688945
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.33070433449487 0.0854199266347538 no 315 0.0916431581259774 490 2374 Ca(2+)-ATPase inhibitor.
SGTC_780 0109-0199 192 µM 1.32869801993925 0.0857238987105268 no 316 0.0919738092286205 574 610414
SGTC_2463 5473429 200 µM 1.32854739708075 0.0857467518684252 no 317 0.09199866826699 501 5399405
SGTC_406 estrone 100 µM 1.32815985613665 0.0858055722354442 no 318 0.0920626515149404 536 5870 A steroid.
SGTC_3226 9131256 49.47 µM 1.3272794935645 0.0859393045332251 no 319 0.0922081223412955 373 17178073
SGTC_1917 st066507 28.5 µM 1.32572223568613 0.0861762431138125 no 320 0.0924658596943298 573 3156428
SGTC_1141 3253-0389 52.6 µM 1.32376389966977 0.0864748994051244 no 321 0.0927907345049895 510 5402031
SGTC_1560 lithocholic acid 53.1 µM 1.32262820305885 0.0866484531078589 no 322 0.0929795252264561 420 9903 A bile acid which acts as a detergent.
SGTC_2551 apiole 73.87 µM 1.32225930859299 0.0867048824162617 no 323 0.0930409088652283 372 10659 A possible DNA adduct former.
SGTC_2628 lathosterol 100 µM 1.31964925258113 0.0871049241222546 no 324 0.0934760752854334 536 6710616
SGTC_522 1273-0010 11.6 µM 1.31942351245162 0.0871395878332522 no 325 0.0935137827398293 512 5705015
SGTC_1472 k841-0093 193 µM 1.31907793188694 0.0871926736954052 no 326 0.0935715300075092 577 X1472
SGTC_2863 9028737 58.44 µM 1.3161589835992 0.0876420275006983 no 327 0.0940603435841808 466 6460917
SGTC_253 dyclonine 31.25 µM 1.31085940800092 0.0884622765984944 no 328 0.0949526335311148 589 3180 An oral anasthetic.
SGTC_3117 9124945 49.47 µM 1.30994393997949 0.0886045468998343 no 329 0.0951074005143148 458 17592065
SGTC_1631 benzylvanillin 81.9 µM 1.30856964773139 0.0888184416453983 no 330 0.0953400839758619 552 75506
SGTC_2182 6325192 200 µM 1.30666583523059 0.0891153857814304 no 331 0.0956631133397994 517 736248
SGTC_3351 9150312 21.596 µM 1.30446807789207 0.0894590955134906 no 332 0.0960370183558502 545 4904905
SGTC_1467 k284-1082 293 µM 1.30294585224701 0.0896977354053215 no 333 0.0962966241728222 568 3334705
SGTC_1895 st058434 18.3 µM 1.30163099183604 0.089904247259828 no 334 0.0965212800367004 554 5393175
SGTC_1905 st060207 84.5 µM 1.30134260975997 0.0899495877334883 no 335 0.0965706041846135 545 1948547
SGTC_2114 5491910 81.25 µM 1.30003176489265 0.0901558976904375 no 336 0.0967950411930731 547 2849228
SGTC_280 3448-3607 3.04 µM 1.29951367292721 0.0902375354881661 no 337 0.0968838521188139 530 626179
SGTC_1674 st016616 23.6 µM 1.29070404647363 0.0916341192863817 no 338 0.0984031604963738 541 625830
SGTC_2525 harmine 47.85 µM 1.28572302537517 0.0924308113516797 no 339 0.0992698712298306 490 5280953 A monoamine oxidase inhibitor
SGTC_331 k048-0133 24.5 µM 1.28508338777426 0.0925334887350711 no 340 0.099381572998893 492 6813582
SGTC_1265 0819-1001 68.8 µM 1.28276798384499 0.0929058729372237 no 341 0.0997866869803046 529 3106768
SGTC_1301 naphtanilide LB 4.81 µM 1.27862127536299 0.0935755510711578 no 342 0.100515227117632 593 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_826 1683-5028 118 µM 1.27444258389255 0.094253993595071 no 343 0.101253304351676 549 722377
SGTC_876 0720-0963 56.8 µM 1.2722231986869 0.0946157996491778 no 344 0.101646913642811 605 765861
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.27132058870127 0.0947632363704019 no 345 0.10180731034952 539 229346 A bile salt which induces apoptosis.
SGTC_2783 7738165 71.43 µM 1.27038868201613 0.0949156361267281 no 346 0.101973106400321 457 17201110
SGTC_1054 3429-0080 167 µM 1.25559046127194 0.0973599179243664 no 347 0.104632245760294 605 1162877
SGTC_356 1634-0012 32.5 µM 1.2553977746842 0.0973920464773584 no 348 0.104667198389686 619 735457
SGTC_2204 7233102 200 µM 1.25475572720514 0.0974991575785314 no 349 0.10478372444598 500 2172480
SGTC_2 0422-0095 29 µM 1.2530162805898 0.0977897789721561 no 350 0.105099890887317 464 6790840
SGTC_1315 1237-0019 3.69 µM 1.2516696874385 0.0980151993350746 no 351 0.105345124953124 597 825140
SGTC_1619 st003326 88.7 µM 1.24731281362037 0.0987471508792398 no 352 0.106141410447716 541 2849032
SGTC_1837 st055472 66.5 µM 1.24563860657517 0.0990294777367932 no 353 0.106448551043614 584 676091
SGTC_917 harmaline 728.087 nM 1.24520399594361 0.0991028639476697 no 354 0.106528387072526 596 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_717 1532-0246 73.2 µM 1.24495752609109 0.0991444993033022 no 355 0.106573681685264 598 9561992
SGTC_7 0192-1582 4.227 µM 1.24380542280061 0.0993392900510833 no 356 0.106785592048275 700 252616
SGTC_1861 st057647 17.4 µM 1.24263480305043 0.0995374978725276 no 357 0.10700121945771 611 688668
SGTC_2810 7959871 45.46 µM 1.24252118675911 0.0995567506122179 no 358 0.107022164214362 640 2974535
SGTC_495 decylubiquinone 155 µM 1.2424880524596 0.099562365865692 no 359 0.107028272960801 571 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1487 3970-0795 2.82 µM 1.23881130999144 0.100186900244693 no 360 0.107707692214795 623 3765103
SGTC_1163 k060-0048 49.9 µM 1.23826514165693 0.100279916255236 no 361 0.1078088822452 632 6809982
SGTC_2201 6605497 169.863 µM 1.23790494213983 0.100341295052145 no 362 0.10787565480911 550 670741
SGTC_2788 5282734 71.43 µM 1.23533701334361 0.100779670447841 no 363 0.108352551949009 659 743706
SGTC_1892 st058411 7.36 µM 1.23401913246259 0.101005189643459 no 364 0.108597887498994 669 3934738
SGTC_599 1935-0052 86.5 µM 1.23378675274057 0.101044993186427 no 365 0.108641188510649 622 9557311
SGTC_2288 7946289 167.31 µM 1.23165406993589 0.101410827336142 no 366 0.109039166920766 664 1246052
SGTC_2645 abamectin 100 µM 1.23125938773294 0.101478635628216 no 367 0.109112933039041 583 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_147 4466-0538 29.23 µM 1.2264084075719 0.102314755918244 no 368 0.110022511853801 622 6742687 YHR072W ERG7
SGTC_1726 st035556 14.5795 µM 1.22454760451786 0.102636811975707 no 369 0.110372859799265 651 5919439
SGTC_2227 7312221 64.1025 µM 1.22111202760252 0.103233354881738 no 370 0.111021803180885 564 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1370 2001-0092 44.6 µM 1.22021754738676 0.103389081898664 no 371 0.111191208300949 703 790957
SGTC_13 0199-0087 65 µM 1.21933143870553 0.103543519520909 no 372 0.111359210351324 622 4589825
SGTC_2186 6124449 200 µM 1.21879948772357 0.103636312283214 no 373 0.111460152999595 598 3834182 YLR033W RSC58
SGTC_2003 4023581 200 µM 1.21878184721684 0.103639390501106 no 374 0.111463501571298 590 16641307
SGTC_2357 9067248 200 µM 1.21707763708248 0.103937083151174 no 375 0.111787339158146 566 9150235
SGTC_1755 st041960 45.185 µM 1.21563131547668 0.104190213710568 no 376 0.112062699669982 597 2257073
SGTC_3078 9116413 49.47 µM 1.21191421546065 0.104842818033699 no 377 0.112772609991126 554 17177322
SGTC_2855 9016525 58.44 µM 1.21118005048246 0.104972063270102 no 378 0.112913203388635 619 43811474
SGTC_1720 st037298 9.481 µM 1.21031766127744 0.105124028859092 no 379 0.11307851161468 569 597396
SGTC_1020 4335-0961 93.3 µM 1.20030456622419 0.106900149778983 no 380 0.115010538515436 569 669075
SGTC_3149 9097855 49.47 µM 1.19870911202098 0.107185139029119 no 381 0.115320536850396 601 25236625 YMR079W SEC14
SGTC_107 0358-0022 2.6945 µM 1.19820610632865 0.107275102301232 no 382 0.115418394379643 467 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2898 9056270 58.44 µM 1.19761797111241 0.107380360131876 no 383 0.115532888300411 549 19154699
SGTC_856 0433-0016 11.3 µM 1.19544544585806 0.107769819668825 no 384 0.115956519374681 647 3911780
SGTC_1618 st003135 44.5 µM 1.19361189427282 0.108099303729581 no 385 0.116314909553098 618 1270615
SGTC_942 3253-1115 227 µM 1.1932126253775 0.108171147278259 no 386 0.116393055654667 613 46497897
SGTC_198 3454-2873 16.191 µM 1.19316816220686 0.108179150007759 no 387 0.116401760423606 626 710957
SGTC_393 acivicin 6.25 µM 1.19105653043369 0.10855970413861 no 388 0.116815696642665 563 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1215 3852-0577 11.2 µM 1.18837415337477 0.109044504201083 no 389 0.117343017360736 701 2884876
SGTC_815 1582-0027 36.9 µM 1.1871518141469 0.109265939323506 no 390 0.117583871794404 628 3128206
SGTC_1735 st034310 56.75 µM 1.18676312756732 0.109336420210361 no 391 0.117660533381394 628 871153
SGTC_1740 st038286 13.222 µM 1.18667193132158 0.109352961636737 no 392 0.117678525358653 632 716786
SGTC_2794 7785382 27.27 µM 1.18572321512442 0.10952514902735 no 393 0.117865811729423 733 2205081
SGTC_21 0849-0113 22.993 µM 1.18536537032867 0.109590146666077 no 394 0.117936508733365 640 1560156
SGTC_2582 agaric acid 100 µM 1.1853497176726 0.109592990390204 no 395 0.117939601808645 865 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_936 3005-4620 401 µM 1.18410537745293 0.109819227669483 no 396 0.118185675865868 709 777207
SGTC_2374 9071832 200 µM 1.1829913151629 0.110022062954354 no 397 0.118406294699569 605 17381698
SGTC_250 brefeldin a 552.239 µM 1.1828653314951 0.110045017476503 no 398 0.118431261676675 539 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1055 3448-0672 86 µM 1.18140012695578 0.110312233593816 no 399 0.118721903812499 625 748378
SGTC_3230 9131665 49.47 µM 1.1811196398243 0.110363440346331 no 400 0.118777599452025 499 15943720
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.17905345459447 0.110741175930983 no 401 0.119188445559125 614 75037 A free radical scavenger.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.17585307488284 0.111328089858093 no 402 0.119826796552234 697 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2851 9015922 71.43 µM 1.17511142305083 0.111464417737265 no 403 0.119975070582956 641 2996893
SGTC_701 4424-0219 185 µM 1.17456498486762 0.111564938529993 no 404 0.12008439942675 714 2911779
SGTC_3304 9125678 46.087 µM 1.16471646616109 0.113387766205128 no 405 0.122066890753495 663 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_795 0685-0265 78 µM 1.1622888683164 0.113840326859463 no 406 0.122559073375938 663 302754
SGTC_2141 5621638 7.665 µM 1.1593929065725 0.114381883327879 no 407 0.123148033422508 640 2856238
SGTC_2424 5537928 59.2 µM 1.15935214672519 0.114389518650121 no 408 0.123156337001296 695 5382802
SGTC_2568 diosmetin 100 µM 1.15860436086002 0.114529661740825 no 409 0.123308745260936 689 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_321 4534-3890 65.3 µM 1.1552545916725 0.115158944218573 no 410 0.123993092495527 659 699746
SGTC_1236 0330-0013 258 µM 1.15379508544378 0.115433892292323 no 411 0.124292094761812 633 4617066
SGTC_1368 1852-0141 284 µM 1.15322392995576 0.115541615921676 no 412 0.124409241914518 628 2838987
SGTC_1237 0330-0133 46.1 µM 1.15293222852314 0.115596660249497 no 413 0.124469101269546 617 X1237 YHR072W ERG7
SGTC_1466 k213-0079 57.5 µM 1.1512258881334 0.115919021476978 no 414 0.124819658740453 675 3657981
SGTC_1078 idebenone 36.1 µM 1.1509238873532 0.115976141773897 no 415 0.124881774788006 711 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_210 3551-0445 56.827 µM 1.150733232387 0.116012212459624 no 416 0.124921000153439 671 2865180 YOR207C RET1
SGTC_1971 st069429 63.5 µM 1.14983812607552 0.1161816672475 no 417 0.125105274452013 629 1246522 YGL099W LSG1
SGTC_1871 st057448 67.3 µM 1.14696447487059 0.116726872215779 no 418 0.125698151773638 694 691747
SGTC_3235 9132602 49.47 µM 1.14543107951697 0.117018537531193 no 419 0.126015315004855 694 4912240
SGTC_26 0302-0163 425.158 µM 1.14510303630828 0.117081001242439 no 420 0.126083238940439 672 3100915
SGTC_3254 9136651 49.47 µM 1.14340735425883 0.117404257928633 no 421 0.126434750239436 689 16454030
SGTC_767 0929-0023 86 µM 1.14326778736018 0.117430892414951 no 422 0.12646371254317 770 1204563
SGTC_1482 3346-2049 8.48 µM 1.14124623705797 0.11781715827974 no 423 0.126883734064024 639 3826804
SGTC_487 nimodipine 119 µM 1.13647874604454 0.118731660177504 no 424 0.127878127871967 561 4497 L-type voltage-gated calcium channels inhibitor
SGTC_478 N-arachidonylglycine 10 µM 1.13562159651913 0.118896609332147 no 425 0.128057483190609 542 5283389
SGTC_1554 st069299 38.7 µM 1.13409093493448 0.119191571017397 no 426 0.128378202864702 668 24207999
SGTC_1913 st060213 96.1 µM 1.13262934342656 0.119473704484797 no 427 0.128684970350228 716 688959
SGTC_805 3852-0218 479 µM 1.13219523101522 0.119557592613677 no 428 0.128776182324724 645 6615355
SGTC_1772 st048439 82.2 µM 1.13082250985851 0.119823131423576 no 429 0.129064901822684 686 2927068 YDL195W SEC31
SGTC_1073 triclabendazole 3.09 µM 1.1283439262598 0.120303640644362 no 430 0.129587349563166 726 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2251 lansoprazole 556 µM 1.12742265543276 0.120482587877109 no 431 0.129781912397804 537 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2714 st079313 56.9 µM 1.12441812222785 0.121067489310589 no 432 0.13041784380165 666 2939799
SGTC_2955 9076254 12.21 µM 1.12219973359761 0.121500629644779 no 433 0.13088876294815 639 16459619
SGTC_822 1487-0950 154 µM 1.1211799295874 0.121700111409382 no 434 0.131105640556975 680 1958375
SGTC_652 0437-0092 114 µM 1.11438377483672 0.123035371068815 no 435 0.132557290478797 661 3091274
SGTC_2876 9059903 25.97 µM 1.11194804495476 0.123516416497664 no 436 0.133080244784796 752 6916095
SGTC_533 1222-0222 6.71 µM 1.10833185466805 0.124233024504367 no 437 0.133859261562406 752 3982874
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.10694271914821 0.124509076370581 no 438 0.134159347295208 729 2724 A muscle relaxant with antifungal properties.
SGTC_1773 st048542 73.5835 µM 1.10618706449096 0.124659421581322 no 439 0.134322780277402 692 3237138
SGTC_1906 st060206 94.7 µM 1.10465321130987 0.124964987411736 no 440 0.134654942315169 753 5133468
SGTC_61 0978-8327 98.565 µM 1.10116093894488 0.125662649500062 no 441 0.135413309347027 743 6150059 YHR072W ERG7
SGTC_1423 4048-0112 5.59 µM 1.10049176246774 0.125796642603685 no 442 0.13555895839709 707 X1423
SGTC_270 tamoxifen 5.46 µM 1.10044573416108 0.125805862781406 no 443 0.13556898059379 770 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2041 5107442 45.335 µM 1.09983904433412 0.125927436137948 no 444 0.135701128592743 717 793005
SGTC_1332 1480-0653 17.5 µM 1.09799529041937 0.126297405010272 no 445 0.136103272888614 689 5749438
SGTC_741 4582-0002 126 µM 1.09392961457662 0.127115901107696 no 446 0.136992924576165 705 2912688
SGTC_1084 voriconazole 435 nM 1.09309706605858 0.12728396288352 no 447 0.137175592021272 733 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2329 6138490 200 µM 1.08775087898158 0.128366849900157 no 448 0.138352549949729 621 720019
SGTC_279 1273-0055 2.93 µM 1.07908037428212 0.130136654720451 no 449 0.140275949659518 790 2847562
SGTC_3128 9127691 49.47 µM 1.07766610427284 0.130426926597325 no 450 0.140591395132974 611 41316314
SGTC_471 1-acyl-paf 4 µM 1.07630719255146 0.13070625803659 no 451 0.140894946490035 708 16759367
SGTC_2764 methyldopa 94.69 µM 1.07414308871555 0.13115195416049 no 452 0.141379277495168 755 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2928 9011484 9.79 µM 1.07091153984339 0.131819442335933 no 453 0.142104603300466 678 2994751
SGTC_1281 0884-0031 11.8 µM 1.06852903284626 0.132313056274255 no 454 0.142640970675687 757 1548255
SGTC_2526 patulin 37.61 µM 1.06354266920707 0.13335026343705 no 455 0.143767962865303 784 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_973 1325-0077 65.9 µM 1.06198639228956 0.133675124889615 no 456 0.144120931398689 792 2835149
SGTC_111 0083-0039 52.457 µM 1.06108309358215 0.133863931272337 no 457 0.144326070185533 615 759313
SGTC_2284 7945075 39.21 µM 1.06048606649915 0.133988821695619 no 458 0.144461762778784 832 1245402
SGTC_3119 9125183 49.47 µM 1.05905000044683 0.134289556164543 no 459 0.144788504521416 589 22695334
SGTC_578 3460-0051 92 µM 1.05850246391004 0.134404340766907 no 460 0.144913214030656 850 2876744
SGTC_3297 9117502 71.43 µM 1.05633891998266 0.134858561235892 no 461 0.14540670032852 771 7453720
SGTC_2887 9044784 58.44 µM 1.05623924881352 0.134879511824868 no 462 0.1454294616942 820 6465546
SGTC_1529 apigenin 74 µM 1.05531713304296 0.135073443752638 no 463 0.14564015392712 749 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3205 9113483 49.47 µM 1.05359812783727 0.135435481313221 no 464 0.146033473351757 763 17018033
SGTC_838 0109-0203 71.4 µM 1.05359776897244 0.135435556962662 no 465 0.14603355553677 770 759422
SGTC_2065 5221596 34.26 µM 1.05040520080895 0.136109703143535 no 466 0.14676592776177 728 788581
SGTC_2545 solidagenone 89.61 µM 1.04999311627482 0.136196886436736 no 467 0.146860638827094 512 6708572 An anti ulcer agent
SGTC_2155 5570423 76 µM 1.0480073856543 0.136617536286594 no 468 0.147317602051648 713 797402
SGTC_1615 st002656 86.5 µM 1.04616430212283 0.137008762488408 no 469 0.147742590665866 756 1584458
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.04431015371294 0.137403109153825 no 470 0.148170958323557 749 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2744 captopril 92.04 µM 1.03625836905758 0.139124575741748 no 471 0.150040811251752 698 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2076 5212012 200 µM 1.03578092169418 0.139227112709892 no 472 0.150152180031522 675 604802
SGTC_1967 st070177 51.4 µM 1.03436573509067 0.139531341355262 no 473 0.15048260835138 747 5729214
SGTC_1670 st016595 4.04 µM 1.03359732565733 0.139696718833639 no 474 0.150662225076058 792 597879
SGTC_548 1436-0017 110 µM 1.03308021130045 0.139808087445725 no 475 0.150783181579535 852 9677137
SGTC_1254 0550-0035 264 µM 1.03122707566445 0.140207684578536 no 476 0.151217173243269 819 15121435
SGTC_2774 tamoxifen 10.92 µM 1.03065678249048 0.140330814543196 no 477 0.151350899039412 768 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1797 st048695 56.8 µM 1.02909855696183 0.140667619799153 no 478 0.151716682103578 776 592262 YIL048W NEO1
SGTC_1651 st011928 86.1 µM 1.02691117097819 0.141141340899001 no 479 0.152231146819236 771 720198
SGTC_1149 3909-7961 23.3 µM 1.02483436449914 0.141592113857449 no 480 0.152720674326325 764 735261
SGTC_2476 5806916 10.51 µM 1.02211230071515 0.142184416099138 no 481 0.153363875965215 759 2870194
SGTC_959 1222-0044 107 µM 1.02091510366588 0.142445448040333 no 482 0.153647331327579 793 6083612
SGTC_10 0279-0212 42.575 µM 1.01923774287704 0.142811717835422 no 483 0.154045056161857 879 39851 YBR002C RER2
SGTC_587 k089-0003 57 µM 1.01887570742649 0.142890855629571 no 484 0.154130988936398 665 9659696
SGTC_645 0845-0943 5.41 µM 1.01715655819684 0.143267051139256 no 485 0.154539479110927 747 1885106
SGTC_2641 levomentholum 100 µM 1.0168525129788 0.143333653855661 no 486 0.154611798248301 751 16666
SGTC_2654 protoveratrine a 100 µM 1.01559109815968 0.14361019674511 no 487 0.154912072831155 777 5702278 A heart drug and vasodilator.
SGTC_333 3486-0131 40.1 µM 1.01551661105198 0.143626537978607 no 488 0.15492981621509 821 6744690
SGTC_492 tmb-8 126 µM 1.01509203908332 0.143719705974698 no 489 0.15503097804993 630 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2606 farnesol 9.78 µM 1.01281526909128 0.14422001559015 no 490 0.155574203003843 788 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_779 1360-0071 233 µM 1.00926804614434 0.145001838489735 no 491 0.156423050183402 853 7566
SGTC_264 promethazine 12.5 mM 1.00883051961937 0.145098468462998 no 492 0.156527960784747 926 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1713 st033146 12.748 µM 1.0069014847514 0.145525022384443 no 493 0.156991059212523 805 674619
SGTC_1644 st010134 20.9 µM 1.00482787330406 0.145984485055243 no 494 0.157489869889698 760 3818134
SGTC_543 3844-1095 191 µM 1.00454607974903 0.146046998908966 no 495 0.157557736097513 834 4230703
SGTC_2151 5563267 85.4165 µM 1.00382608249806 0.146206806740098 no 496 0.157731225066514 819 5310824
SGTC_2192 5915882 198.485 µM 1.00333656770326 0.146315524611046 no 497 0.157849249116206 763 2876149
SGTC_2790 5423970 71.43 µM 1.00156463758629 0.146709511895156 no 498 0.15827695362412 842 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1805 st050013 60.3 µM 1.00121317307129 0.146787744278343 no 499 0.158361879629298 775 4037144
SGTC_1868 st057644 42.7 µM 0.999967395536319 0.147065266912714 no 500 0.15866314338577 861 688665
SGTC_3180 9109287 49.47 µM 0.998944865511038 0.147293319294164 no 501 0.158910700282259 751 18891271
SGTC_872 0588-0139 234 µM 0.996867332668892 0.147757396032339 no 502 0.159414455015808 817 2047100
SGTC_2935 9038016 29.96 µM 0.994454285768605 0.148297647306391 no 503 0.160000875301234 848 6463195
SGTC_2379 9035213 200 µM 0.991870706129668 0.14887754176895 no 504 0.160630300339222 874 646551
SGTC_167 3672-0051 66.205 µM 0.991829149513616 0.14888688167776 no 505 0.160640437774823 738 3237971
SGTC_1424 4048-1941 275 µM 0.990155561084506 0.14926334846229 no 506 0.161049044810265 901 X1424
SGTC_165 k038-0023 64.381 µM 0.988191378595381 0.149705993239751 no 507 0.16152946484244 817 46368543
SGTC_2685 mycophenolic acid 18.85 µM 0.987592629239997 0.149841100353516 no 508 0.161676098775969 818 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1702 st027038 51 µM 0.987362596259045 0.149893028652637 no 509 0.161732456998175 821 5521182
SGTC_885 0865-0106 16.8 µM 0.987339507456142 0.149898241447345 no 510 0.161738114476086 802 2793380
SGTC_357 1325-0123 420 µM 0.986742738201145 0.150033016910324 no 511 0.161884386330739 800 1098503
SGTC_1345 1488-0192 31.4 µM 0.986734438897773 0.150034891809655 no 512 0.161886421149036 848 658348
SGTC_1214 0358-0031 63.7 µM 0.985925351804502 0.15021774803194 no 513 0.162084872641847 795 4301366
SGTC_1749 st037932 54.2 µM 0.985364117846167 0.150344675883371 no 514 0.162222624171343 771 594497
SGTC_2682 pyrogallin 40.03 µM 0.985200356150883 0.150381725453435 no 515 0.162262832864384 868 822798 An ATP competetive kinase inhibitor.
SGTC_576 1073-0113 22.7 µM 0.984801597280296 0.150471966401664 no 516 0.162360767953609 1015 5439563
SGTC_2028 5153890 36.43 µM 0.98445931849064 0.150549454416557 no 517 0.162444862227417 793 2830968 YPR165W RHO1
SGTC_1329 1447-1697 50.6 µM 0.979887443078534 0.151587023194077 no 518 0.163570840976291 818 2840515
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.979836868060128 0.151598527510877 no 519 0.16358332505703 837 23665772 A membrane-active detergent.
SGTC_2289 7946404 165.07 µM 0.976753076430684 0.152301095263553 no 520 0.164345705797868 872 1246120 YPR165W RHO1
SGTC_1455 4262-0120 131 µM 0.975177220188761 0.152660949357999 no 521 0.164736179852522 861 1529587
SGTC_516 3992-2719 87.3 µM 0.973821528322566 0.152970978873105 no 522 0.16507258093741 778 5350887 YDR037W KRS1
SGTC_3001 9076041 71.4286 µM 0.973027385465819 0.153152783003876 no 523 0.165269845787827 811 16004211
SGTC_626 0214-0009 33 µM 0.972304087269235 0.153318493134754 no 524 0.165449645537323 864 3437874
SGTC_1663 st014140 55.4 µM 0.971933875911411 0.153403355787367 no 525 0.165541722786455 957 4207120
SGTC_2747 doxorubicin 7.63 µM 0.970964990418694 0.153625598310086 no 526 0.165782856328968 649 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1021 4476-0760 85.3 µM 0.969605889252451 0.153937707429813 no 527 0.166121488134574 785 746768
SGTC_353 1988-1175 58.3 µM 0.96813899993634 0.154275039940424 no 528 0.166487477354975 778 2788357
SGTC_1406 3909-7906 11.9 µM 0.964993263374888 0.15500009481167 no 529 0.167274092991754 852 X1406
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.964217760881781 0.155179184111499 no 530 0.167468380830724 878 6708561
SGTC_261 5-fluorouridine 15.376 µM 0.96382049321743 0.155270979308729 no 531 0.167567965208105 847 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3292 9120825 59.784 µM 0.96303545271616 0.155452481136021 no 532 0.167764866007557 869 24824900
SGTC_1088 bifonazole 369 nM 0.961918747525708 0.155710905129125 no 533 0.16804521022981 824 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2056 5235370 200 µM 0.961055908792328 0.1559107741482 no 534 0.16826202867159 791 5511916
SGTC_3062 9077494 49.47 µM 0.959729877870612 0.156218267097907 no 535 0.168595590985545 806 16459633
SGTC_1361 1608-0041 5.61 µM 0.959418190864554 0.156290602066673 no 536 0.16867405733012 852 X1361
SGTC_2035 5154463 94.595 µM 0.958973811733557 0.156393769793852 no 537 0.168785969132061 843 2769623
SGTC_2206 7254556 146.969 µM 0.957892767152522 0.156644933956099 no 538 0.169058417013494 838 4398905
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.956415096182071 0.156988677469873 no 539 0.169431280398807 809 689007
SGTC_3047 9092122 49.47 µM 0.956298563101639 0.15701580709481 no 540 0.169460707835466 797 17173831
SGTC_1872 amphotericin b 148 nM 0.955040402473947 0.157308911082587 no 541 0.169778632831995 895 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1439 4092-1168 46 µM 0.954691123343603 0.157390343698024 no 542 0.169866960072251 863 2886240
SGTC_2176 5809774 33.9695 µM 0.952498561290114 0.157902160947837 no 543 0.170422097618129 892 2870539
SGTC_758 0868-0029 16 µM 0.949533553227902 0.158596029260387 no 544 0.171174657591111 881 762687
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.948573968049957 0.158821018064081 no 545 0.171418668035064 884 688751
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.947842391847677 0.158992687303155 no 546 0.171604847947236 911 676296 Flavone; oxidizing agent.
SGTC_180 1486-1293 102.781 µM 0.947204094689275 0.159142567274597 no 547 0.171767394632952 871 4140536
SGTC_2321 7390090 138.78 µM 0.945047890082664 0.159649554627857 no 548 0.172317213602793 759 649046
SGTC_1531 st059297 52.4 µM 0.944242572846974 0.159839179281419 no 549 0.172522852239697 874 7566702
SGTC_2466 5983409 37.09 µM 0.942543239172472 0.160239797480462 no 550 0.172957292247355 828 2879657
SGTC_1178 0988-0033 191 µM 0.941652931038502 0.160449949550829 no 551 0.173185180339116 856 5392207
SGTC_288 1315-0019 35.1 µM 0.94129783576915 0.160533817940748 no 552 0.173276125767202 886 6811474
SGTC_2906 7926292 26.41 µM 0.939894225718421 0.160865610698839 no 553 0.173635909754174 856 2966319
SGTC_3048 9093155 49.47 µM 0.9397809649877 0.160892403374543 no 554 0.173664962314841 810 25236002
SGTC_3334 9142812 21.919 µM 0.937283621114926 0.161483909002586 no 555 0.174306342887891 841 45283678
SGTC_1997 st073024 93.8 µM 0.936581449945336 0.161650476041705 no 556 0.174486948800987 868 686268
SGTC_1227 3909-8010 46.6 µM 0.932831205629884 0.162541993894407 no 557 0.175453563243436 843 15982272
SGTC_3262 9137218 49.47 µM 0.932697261613102 0.162573894475912 no 558 0.175488149584472 724 17650664
SGTC_273 hydroxyurea 18.1 mM 0.930648832825915 0.163062262988679 no 559 0.176017622727965 945 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_991 3996-0057 64.7 µM 0.930587417926095 0.163076919701362 no 560 0.176033512710682 838 715343
SGTC_2235 salicylic acid 500 µM 0.92755806786881 0.163800939143311 no 561 0.176818428711421 871 338 A COX inhibitor and kinase inhibitor.
SGTC_2675 theaflavin digallate 100 µM 0.927003070398866 0.163933810197681 no 562 0.176962470058827 892 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2283 7944793 200 µM 0.926704823655653 0.164005241853614 no 563 0.177039906190409 884 2970533
SGTC_3157 9099274 49.47 µM 0.925148456607221 0.164378327488595 no 564 0.177444345201939 866 17217662
SGTC_728 3030-5151 22.5 µM 0.924161647078785 0.164615166040557 no 565 0.177701080354556 852 3125388
SGTC_160 3453-0671 289.699 µM 0.922496601542935 0.165015285217516 no 566 0.178134801091948 956 5322268
SGTC_2879 9041815 71.43 µM 0.919886579953596 0.165643753161127 no 567 0.178816016264933 805 4942971
SGTC_2789 5281112 71.43 µM 0.919660716666415 0.165698211527394 no 568 0.178875043537067 857 765948
SGTC_1640 st009078 66.4 µM 0.918850295500596 0.165893709136301 no 569 0.179086940512192 839 690618
SGTC_2184 6075246 200 µM 0.918000824246882 0.166098786746374 no 570 0.179309217169267 879 2267320
SGTC_3028 9087778 49.47 µM 0.917020469283551 0.166335665531429 no 571 0.179565957010321 923 17217395
SGTC_124 0136-0217 7.121 µM 0.916129032437865 0.166551248703423 no 572 0.179799611017378 1002 3976905
SGTC_2601 securinine 100 µM 0.913390796361065 0.16721458513339 no 573 0.180518522177526 843 442872 A GABA receptor antagonist.
SGTC_1313 1220-0047 237 µM 0.913176549485211 0.167266558081281 no 574 0.180574847651905 935 3528706
SGTC_807 1315-0151 48 µM 0.910382974194723 0.167945188680512 no 575 0.181310286773724 975 4011080
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.909538705250401 0.168150631363709 no 576 0.181532918330886 998 6708784 An antioxidant flavonoid
SGTC_145 3737-0113 38.366 µM 0.909286665379808 0.168211993559442 no 577 0.181599413748809 1022 6849351
SGTC_1125 tnp00248 1.32998 µM 0.908207805666535 0.16847481796398 no 578 0.181884220427754 1024 24207736
SGTC_2129 girgensonine 121.053 µM 0.906412095287776 0.168912861771582 no 579 0.182358886592906 949 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1603 st002045 67.8 µM 0.906239035622064 0.168955116395461 no 580 0.182404672890849 928 5887985
SGTC_1193 1488-0126 41.5 µM 0.905809756066684 0.169059959531927 no 581 0.182518278140102 924 1384710
SGTC_2779 methotrexate 400 µM 0.903562038671166 0.169609602506371 no 582 0.183113839028747 973 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_39 0986-0283 58.349 µM 0.903096947616277 0.169723475993044 no 583 0.183237221935386 969 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_63 0099-0242 26.702 µM 0.902718876983827 0.169816079410671 no 584 0.183337557594178 965 3898502 YLR359W ADE13
SGTC_2086 5274770 176.623 µM 0.901399442738544 0.170139511217527 no 585 0.183687988799361 893 689278
SGTC_2626 ethyl orsellinate 100 µM 0.900834604215825 0.170278090196268 no 586 0.18383813288577 883 75653 A natural product.
SGTC_1784 st039334 36.3 µM 0.900535996117577 0.17035138070827 no 587 0.183917539087019 901 3496984
SGTC_1157 4092-0394 27.6 µM 0.898328863257895 0.17089372694056 no 588 0.18450512453799 981 3659885
SGTC_1460 k062-0059 9.15 µM 0.896934985516134 0.171236805139985 no 589 0.184876805106845 881 1373085
SGTC_977 1348-1378 135 µM 0.892621544991713 0.172301269462933 no 590 0.186029938689817 984 X977
SGTC_3232 9132874 49.47 µM 0.890313594155054 0.172872552068196 no 591 0.186648761842567 904 3784940
SGTC_2475 5812728 15.03 µM 0.889700129061284 0.173024604727877 no 592 0.186813462350693 1010 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3007 9078383 71.4286 µM 0.887894187592773 0.173472717439788 no 593 0.187298835787722 921 6496995
SGTC_277 nystatin 15.5 µM 0.886306417902269 0.173867304283897 no 594 0.187726215797873 987 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2776 terbinafine 19.92 µM 0.884791943418418 0.174244207511302 no 595 0.188134427759342 917 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_656 4090-1979 187 µM 0.88336054646229 0.174600912341165 no 596 0.188520750132109 986 22330961
SGTC_1035 k081-0041 55.2 µM 0.883132752856269 0.174657721359095 no 597 0.188582274857105 976 731709
SGTC_975 1335-0046 28.5 µM 0.882939675065354 0.174705881853533 no 598 0.188634432887617 927 16486740
SGTC_2390 9097792 176.6 µM 0.882662659267784 0.174774994207573 no 599 0.188709281461015 877 4497149
SGTC_1984 st072354 53.1 µM 0.879692086942652 0.175517209508594 no 600 0.18951306862962 928 5762938
SGTC_2619 obliquin 87.91 µM 0.878907672026276 0.175713533202648 no 601 0.189725669260292 977 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3085 9117376 49.47 µM 0.878767626732125 0.175748598428548 no 602 0.189763641279793 926 16480349
SGTC_1617 st002906 78 µM 0.87830635148924 0.175864126124652 no 603 0.189888744951239 951 5150859
SGTC_2737 bleomycin 30.5 nM 0.878045781423208 0.175929407892559 no 604 0.189959437251291 974 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1843 st055809 45.5 µM 0.872912580887973 0.177218579023136 no 605 0.19135536418432 881 16413835
SGTC_1251 0490-5699 265 µM 0.87124539233137 0.177638563310757 no 606 0.191810089960393 1022 3883818
SGTC_3176 9106582 49.47 µM 0.871159788761464 0.177660144789439 no 607 0.191833456182426 837 17018027
SGTC_294 k038-0071 157 µM 0.869647145808552 0.178041769420724 no 608 0.192246632344891 951 24152826
SGTC_2798 7813637 45.45 µM 0.869302272622233 0.178128849762623 no 609 0.192340910084659 918 956368
SGTC_744 1594-0068 283 µM 0.867399608361768 0.178609754260594 no 610 0.192861548185898 971 668392
SGTC_1359 1582-0056 520 nM 0.865983913496814 0.178968105668304 no 611 0.193249491760189 1001 3661189
SGTC_1075 aripiprazole 15.2 µM 0.864800237376228 0.179268073765029 no 612 0.193574220426663 1000 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2533 agelasine 13.65 µM 0.862938194767527 0.179740593509254 no 613 0.194085724607877 977 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_597 k018-0003 82.8 µM 0.859946896143313 0.18050131449081 no 614 0.194909157977921 1052 6786234
SGTC_2483 5729050 27.16 µM 0.858737323251507 0.180809495098032 no 615 0.195242726935856 1026 2865180
SGTC_2452 5863136 48.41 µM 0.858420680099207 0.180890225355083 no 616 0.19533010619561 966 2184096
SGTC_2738 aclarubicin 5.55 µM 0.858377132093133 0.18090132997292 no 617 0.195342125343592 876 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_683 panaxydol 45 µM 0.857497499966367 0.181125725132992 no 618 0.195584997942487 979 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1583 clindamycin 39.6 µM 0.85669488891883 0.181330624190965 no 619 0.195806764378683 856 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1742 st038235 28.8875 µM 0.854689144639318 0.181843306106799 no 620 0.19636163084896 926 564103 YBR002C RER2
SGTC_2372 9071633 200 µM 0.852330455382031 0.182447361924426 no 621 0.197015353551147 1037 21321366
SGTC_2926 9010726 65.15 µM 0.852154725747374 0.182492416066564 no 622 0.197064110581385 955 2994293
SGTC_5 0352-0601 109.883 µM 0.850532376932562 0.182908687372918 no 623 0.19751458386852 928 762456
SGTC_66 0109-0187 42.4 µM 0.848427821366835 0.183449568151081 no 624 0.198099876991784 884 759417
SGTC_3342 9147791 14.508 µM 0.847577319253496 0.183668433824498 no 625 0.198336705000331 988 1838168
SGTC_1820 st053765 18.6 µM 0.847276656929194 0.183745844276853 no 626 0.198420467298564 965 3690829
SGTC_3055 9094636 49.47 µM 0.846773069642172 0.183875546616767 no 627 0.198560810794776 955 25236176
SGTC_2718 lomofungin 53.02 µM 0.846498600701864 0.183946261965944 no 628 0.198637327068887 950 5351222 A RNA synthesis inhibitor.
SGTC_1197 1601-0112 267 µM 0.845925720917157 0.184093915712745 no 629 0.198797091407731 976 7350313
SGTC_3010 9080089 71.4286 µM 0.843605067928791 0.18469279412088 no 630 0.199445065686489 978 17027233
SGTC_2621 lithochol-11-enic acid 100 µM 0.843453202227636 0.184732027464677 no 631 0.199487514007122 1006 6708711
SGTC_3095 9117207 49.47 µM 0.841720506387498 0.185180022907816 no 632 0.199972208553236 947 17015229
SGTC_1165 k072-0275 30.3 µM 0.840568478341606 0.185478257501279 no 633 0.200294861929487 1002 6153523 YGL055W OLE1
SGTC_935 2996-0153 430 µM 0.837283220702174 0.186330374101354 no 634 0.201216694303396 992 23738523
SGTC_1202 1988-0068 29.6 µM 0.837013511074496 0.186400437842705 no 635 0.201292486754639 955 2850480
SGTC_120 rhodamine 6G 52.259 µM 0.836950366869533 0.186416843467833 no 636 0.201310233695621 1106 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1107 amlodipine 47 µM 0.836356573240607 0.186571161954775 no 637 0.201477167738379 937 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1769 st044406 64.4 µM 0.835945429994817 0.186678058549237 no 638 0.201592801607592 975 670903
SGTC_1246 0422-0085 105 µM 0.834552955831369 0.187040381227768 no 639 0.201984729648093 1007 264295
SGTC_2183 6420625 130.508 µM 0.832219765096731 0.187648453309277 no 640 0.20264245471225 1045 2897619
SGTC_2861 9024595 19.48 µM 0.830570345103672 0.188079058255975 no 641 0.203108196579966 950 16482810
SGTC_816 0325-0417 81.3 µM 0.82826788615321 0.188681167431834 no 642 0.203759402758721 1001 68101
SGTC_2156 5649887 115 µM 0.827878179710874 0.188783195851527 no 643 0.203869746756054 1076 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2914 7968218 45.32 µM 0.827705231918044 0.188828485927294 no 644 0.203918727717745 936 2977111
SGTC_2993 9054257 71.4286 µM 0.827165088163023 0.188969977218503 no 645 0.204071748280287 1059 6470217 YGL055W OLE1
SGTC_677 0929-0063 136 µM 0.825041687554924 0.189526837300487 no 646 0.204673961848206 952 1539583
SGTC_1730 st033808 45.1 µM 0.82384958351909 0.189839907692213 no 647 0.205012515056024 1058 1045166
SGTC_2834 9001755 58.44 µM 0.821919767545965 0.190347389581543 no 648 0.205561280851654 918 2989575
SGTC_2071 5230951 39.92 µM 0.821670821886118 0.190412915210085 no 649 0.205632134917549 1088 1799272
SGTC_123 0083-0120 66.675 µM 0.821334593859313 0.190501436641374 no 650 0.205727854001866 997 16001701
SGTC_2736 butenafine 14.65 µM 0.821111695827291 0.190560134707677 no 651 0.205791324306356 1015 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1132 3456-3614 2.5 µM 0.820348504189222 0.190761198012349 no 652 0.206008731415305 1093 3125502
SGTC_3340 9146634 11.102 µM 0.818336598283491 0.191291859479638 no 653 0.206582506836116 998 4907387
SGTC_2127 5253358 187.912 µM 0.818061984662501 0.191364361843605 no 654 0.206660897240014 929 20612
SGTC_2378 9074213 121.43 µM 0.817415446321175 0.191535124736367 no 655 0.206845525733007 1042 657714
SGTC_2045 5106652 78.05 µM 0.81668899127126 0.191727106462499 no 656 0.207053092053276 1032 673349
SGTC_1169 aniline yellow 25.8 µM 0.813357907366647 0.192608926692978 no 657 0.208006442653394 990 6051 A DNA damaging agent.
SGTC_706 4262-0057 46.9 µM 0.813214030059237 0.19264707033431 no 658 0.208047678392632 1032 883298
SGTC_836 0330-0104 1.35 µM 0.812874693816295 0.192737050821887 no 659 0.208144952455095 1055 46494820
SGTC_3177 9107506 49.47 µM 0.812793423439874 0.192758604786268 no 660 0.208168253388959 994 8897194
SGTC_511 blebbistatin 171 µM 0.811973467470246 0.19297615018565 no 661 0.208403428095326 1008 3476986 A myosin inhibitor.
SGTC_1367 1812-0510 76.9 µM 0.811856873668003 0.193007096268446 no 662 0.208436881530029 1015 1142582 YDR527W RBA50
SGTC_1390 3413-2614 145 µM 0.808101126940392 0.194005559075682 no 663 0.209516184464645 1083 3421432
SGTC_1253 0550-0034 176 µM 0.806304652582666 0.194484261320008 no 664 0.210033604245516 979 5969915
SGTC_1319 1306-0155 43.7 µM 0.805904585910884 0.194590963933489 no 665 0.210148933411027 1058 3122360
SGTC_2873 9040596 71.43 µM 0.805391153000808 0.194727954877029 no 666 0.21029699770331 1047 6463863
SGTC_80 0159-0065 512.242 µM 0.805374238260972 0.194732468959672 no 667 0.21030187663483 969 1548079
SGTC_716 1683-5115 658 µM 0.804520464580136 0.194960400556564 no 668 0.21054822766846 1103 723597
SGTC_2147 5545932 89.7195 µM 0.804224190760181 0.195039534550371 no 669 0.210633755183617 1004 797404
SGTC_2096 5468907 200 µM 0.804071270240743 0.195080386876616 no 670 0.210677907835292 1055 759785
SGTC_1343 1487-0095 224 µM 0.803510519518091 0.195230234501804 no 671 0.210839859515907 1033 4560101 YGL055W OLE1
SGTC_3114 9122766 49.47 µM 0.803227370620626 0.195305926046355 no 672 0.210921664120541 947 17176985
SGTC_566 0958-0068 16.5 µM 0.801808278589883 0.195685547170887 no 673 0.211331934555054 988 6815365
SGTC_3166 9102297 49.47 µM 0.801596137364381 0.195742335504065 no 674 0.211393306356014 1025 25237072
SGTC_444 curcumin 90.4 µM 0.800813009064365 0.195952058643413 no 675 0.211619953327024 991 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2827 7993847 71.43 µM 0.800743383651445 0.195970711048423 no 676 0.211640110661897 951 2985692
SGTC_712 r015-0009 80.6 µM 0.800038015143355 0.19615973753563 no 677 0.21184438608495 986 6813872 YLR060W FRS1
SGTC_2376 9072922 81.32 µM 0.799375894284545 0.196337274974357 no 678 0.21203624186783 1048 17087968
SGTC_2662 daunorubicin 22.37 µM 0.79583014928615 0.197289667860945 no 679 0.213065382667065 1017 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2915 7971052 15.16 µM 0.79535829886882 0.197416618004153 no 680 0.213202555049609 921 5741558
SGTC_2208 7283366 200 µM 0.795089309358235 0.197489011043827 no 681 0.213280776460068 1067 898663
SGTC_258 haloperidol 50.781 µM 0.792561689643917 0.198170052077429 no 682 0.214016618312334 1048 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2691 st077356 60.2 µM 0.792365777241246 0.198222897792643 no 683 0.214073714064213 1064 2839272
SGTC_2899 9053889 58.44 µM 0.792156737613199 0.198279293845748 no 684 0.214134645325094 1034 6470052
SGTC_2302 7771753 200 µM 0.792109227148725 0.198292112874438 no 685 0.214148495171287 1057 2203047
SGTC_432 NS 1619 61.3 µM 0.791575398155441 0.198436182244663 no 686 0.214304148283042 976 4552 A K+/calcium channel activator.
SGTC_974 1326-0144 138 µM 0.787384477732113 0.199569417353956 no 687 0.215528415269067 1072 5411856
SGTC_919 tnp00227 403.569 nM 0.784236973710918 0.200423065600504 no 688 0.216450536870926 1067 1269246 A methoxyflavone. YNL221C POP1
SGTC_2332 7982454 138.89 µM 0.783210201153246 0.200702014804267 no 689 0.216751842714857 1044 2981748
SGTC_1573 oleylamine 1.06 µM 0.782982746111446 0.200763840340852 no 690 0.216818622072993 1057 5356789 An amine of the fatty acid oleic acid.
SGTC_1987 st072290 61.9 µM 0.781963683912108 0.201040976339183 no 691 0.217117958272524 1064 54697379
SGTC_2117 5521686 200 µM 0.780119585706694 0.201543065495271 no 692 0.217660244552219 1053 803312
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.779302373215206 0.201765806434251 no 693 0.21790080851187 1050 5282362
SGTC_299 1273-0059 1.44 µM 0.777964243163065 0.202130847780139 no 694 0.218295046578947 1037 2848077
SGTC_1457 k015-0032 57.3 µM 0.777174707082725 0.202346418157361 no 695 0.218527851265081 1036 4302660
SGTC_993 3909-8757 62.7 µM 0.775771613590462 0.202729849828711 no 696 0.218941923676416 984 4288324 YLR208W SEC13
SGTC_2611 pyromycin 23.93 µM 0.774040455277149 0.203203531531064 no 697 0.219453433987914 1070 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1204 4049-0315 18.3 µM 0.772046700146448 0.203749883043035 no 698 0.220043384321827 1036 588402
SGTC_1470 k295-0292 231 µM 0.771019515926107 0.204031705255436 no 699 0.220347681977114 1101 5045612
SGTC_1067 clotrimazole 1.36 µM 0.770419171506247 0.204196525535273 no 700 0.220525642337482 1105 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_687 k029-0044 34.9 µM 0.7685582205449 0.204707939963735 no 701 0.22107780787431 1114 5829338
SGTC_390 dec-rvkr-cmk 16.7 µM 0.767191133041828 0.205084119032598 no 702 0.221483942023158 1117 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1489 4065-0444 182 µM 0.767133208927088 0.205100066977114 no 703 0.221501159523973 1079 2877968
SGTC_2023 5144124 124 µM 0.766657298766303 0.205231124742651 no 704 0.221642649149462 1058 2830192
SGTC_1796 st049173 110.4 µM 0.766434870409123 0.205292394881093 no 705 0.221708795523551 1050 94134
SGTC_3236 9132701 49.47 µM 0.766264440600869 0.20533934884572 no 706 0.221759486053099 1068 24282524
SGTC_2837 9008476 45.46 µM 0.765829919309874 0.205459089730374 no 707 0.221888754634619 1100 2992805
SGTC_1661 st013063 9.66 µM 0.764840525425141 0.205731891312853 no 708 0.222183256390875 1143 721395
SGTC_1449 4112-4002 201 µM 0.763092343601432 0.20621443555372 no 709 0.222704162923752 1075 2059539
SGTC_3203 9113543 49.47 µM 0.762600767953958 0.206350244142324 no 710 0.222850763228459 1067 17018012
SGTC_2279 7948423 32.93 µM 0.762379531723842 0.206411382809712 no 711 0.222916759410786 1077 1247112
SGTC_3034 9090421 49.47 µM 0.761458936040987 0.206665904803924 no 712 0.22319149851472 1051 17173761
SGTC_990 3985-0011 41.3 µM 0.760226342850488 0.207006977258867 no 713 0.22355965062398 1034 5399565 YGL099W LSG1
SGTC_725 1497-0963 19 µM 0.760208200960322 0.207011999810665 no 714 0.22356507183895 1121 3549977
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.759833922868676 0.207115634158875 no 715 0.223676931441772 1177 65057 A dermal irritant. YDR527W RBA50
SGTC_296 1222-0039 74.9 µM 0.759115190811158 0.207314730849119 no 716 0.223891826387628 1074 5984176
SGTC_1684 st024538 14.6195 µM 0.758475683878484 0.207491976413238 no 717 0.22408313227727 1098 6732859
SGTC_1780 st038448 24.544 µM 0.758397669778508 0.207513604907413 no 718 0.224106476229596 1085 728868 YDL195W SEC31
SGTC_3341 9147222 25.867 µM 0.757562246452882 0.207745299746797 no 719 0.224356544314187 1051 1939759
SGTC_2519 cryptotanshinone 88.04 µM 0.757296218107508 0.207819111646741 no 720 0.224436208076737 1092 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_692 k241-0027 77.8 µM 0.75547809424673 0.208323980575159 no 721 0.224981085602209 1104 3600480
SGTC_840 0245-0196 390 µM 0.755072009204155 0.208436843784776 no 722 0.225102888465618 1149 3827528
SGTC_2098 5376439 882.5 nM 0.754860556989821 0.208495626969919 no 723 0.225166327125802 1154 2844116
SGTC_1402 3909-7673 35.9 µM 0.754127010497274 0.208699626818888 no 724 0.225386479959191 1111 5328014
SGTC_2090 5301565 104.445 µM 0.754024616841385 0.208728111927943 no 725 0.225417220153425 1120 2056344
SGTC_2938 9059746 27.26 µM 0.753528964178036 0.2088660309847 no 726 0.22556605646817 1044 6471769
SGTC_2000 st075254 36.4 µM 0.753453236683632 0.208887107452994 no 727 0.225588801081579 1063 17234175
SGTC_631 k072-0230 41.5 µM 0.746414635152716 0.210851555269417 no 728 0.227708490577189 1129 5773147
SGTC_2474 5321570 43.32 µM 0.743773198798504 0.211591557154915 no 729 0.228506848472018 1119 2841384
SGTC_1117 retinoic acid 1.10837 µM 0.741935850356165 0.21210718814121 no 730 0.229063101751266 1150 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2327 6189656 200 µM 0.740213959040513 0.212591083639889 no 731 0.229585089423778 1137 5349088
SGTC_1637 st007924 17.4 µM 0.739883640592041 0.212683985222987 no 732 0.229685300882058 1119 683336
SGTC_2267 7931562 200 µM 0.739158287735893 0.212888072820315 no 733 0.22990544316176 1074 934880
SGTC_477 mead ethanolamide 10 µM 0.737234416841947 0.213429932566567 no 734 0.230489903542462 1004 16061185
SGTC_1239 0337-0584 35.4 µM 0.736313988586044 0.213689455952189 no 735 0.230769817537399 1174 914301 YML130C ERO1
SGTC_3271 9137798 49.47 µM 0.734724019681001 0.214138195385299 no 736 0.231253794377321 1074 6498326
SGTC_1162 k048-0130 20.1 µM 0.733662734998827 0.214438028353176 no 737 0.231577157821585 1104 6797406
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.733613571354514 0.214451923925031 no 738 0.231592143626447 1004 6708630 An antioxidant.
SGTC_1158 4092-0494 91.8 µM 0.724338462797184 0.217082786112673 no 739 0.234428984552609 1195 1148199
SGTC_1656 st012921 11 µM 0.72406673652769 0.217160140746203 no 740 0.234512382355106 1078 6732821
SGTC_2349 9023730 187.07 µM 0.723946226071563 0.217194452581647 no 741 0.234549374489128 1134 4126287
SGTC_1982 st072467 71.9 µM 0.722751783141574 0.217534704653107 no 742 0.234916197596474 1119 3163533
SGTC_730 1436-0052 41.2 µM 0.722681692463146 0.21755468041511 no 743 0.23493773285525 1184 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2431 5490079 200 µM 0.720950077356789 0.218048524775293 no 744 0.235470115325756 1200 5722345
SGTC_558 k064-0027 21.3 µM 0.719482571521422 0.218467552479532 no 745 0.235921818456973 1154 5088526
SGTC_1809 st050081 57.6 µM 0.716383767957635 0.219353898422408 no 746 0.236877207491589 1209 5036894
SGTC_1682 st012968 530 nM 0.714662700533057 0.219847063877213 no 747 0.237408745459271 1139 24207270
SGTC_2445 5742597 35.57 µM 0.711560391657609 0.220737624437128 no 748 0.238368520709686 1129 1774255
SGTC_3261 9137475 49.47 µM 0.711527335017771 0.220747124913006 no 749 0.23837875901983 1035 17027690
SGTC_2995 9067767 71.4286 µM 0.711011675121049 0.220895355845043 no 750 0.238538500496905 1154 11673567
SGTC_2845 9003024 42.97 µM 0.709976988028444 0.221192957487584 no 751 0.23885920324673 1200 2990173
SGTC_2218 6965428 192.983 µM 0.709708054303947 0.221270347029643 no 752 0.23894259823666 1160 675684
SGTC_2180 6301957 200 µM 0.709644267504677 0.221288704869321 no 753 0.238962380536709 1153 845462
SGTC_1183 1254-0324 198 µM 0.70937314899664 0.221366742490251 no 754 0.239046472936017 1194 5799357
SGTC_1098 clofazimine 15.1 µM 0.706189634292089 0.222284248594251 no 755 0.240035107858376 1197 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2239 6685329 187.64 µM 0.705973941578218 0.2223464907802 no 756 0.240102171396085 1176 805680
SGTC_2937 9044753 11.33 µM 0.705494407178275 0.222484905059988 no 757 0.240251305620073 1204 6465530 YGL099W LSG1
SGTC_458 nppb 133 µM 0.703440246795096 0.223078379976774 no 758 0.240890716173451 1197 4549 A chloride channel blocker.
SGTC_920 mycophenolic acid 780.421 nM 0.701193062071527 0.223728653535454 no 759 0.241591269504985 1175 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1128 3448-9350 235 µM 0.700704254443343 0.223870243607774 no 760 0.24174380021679 1149 619386
SGTC_630 4356-0227 183 µM 0.700541114846758 0.223917510641133 no 761 0.241794718988333 1198 779312
SGTC_1609 st001574 46.4 µM 0.700059188117458 0.224057174154696 no 762 0.241945170883458 1185 3960012
SGTC_2103 5378138 10 µM 0.698807757083114 0.224420072838313 no 763 0.2423360900663 1231 244142
SGTC_3090 9117696 49.47 µM 0.697582478439482 0.224775710649537 no 764 0.242719171192615 1162 7923821
SGTC_1572 epiandrosterone 68.9 µM 0.697304495328551 0.224856439855833 no 765 0.242806127703279 1157 441302 A steroid.
SGTC_2820 7989630 71.43 µM 0.695825023184611 0.225286370499098 no 766 0.243269208169243 1096 2984098
SGTC_1188 1403-0014 4.57 µM 0.695409208495747 0.225407288889423 no 767 0.243399445652568 1228 9614867
SGTC_3125 9127534 49.47 µM 0.695224660440581 0.225460967003017 no 768 0.243457260090608 1085 1639235
SGTC_2854 9024559 71.43 µM 0.693768253181786 0.22588483509408 no 769 0.243913777418354 1181 3163529
SGTC_1991 st073000 8.92 µM 0.693273267397476 0.226028996701654 no 770 0.244069038016359 1243 4301969 YIL048W NEO1
SGTC_1925 st057770 10.1 µM 0.691879778245632 0.226435121141053 no 771 0.244506415385229 1142 5989122
SGTC_2142 5622915 118.518 µM 0.688297332718481 0.227481093557595 no 772 0.245632780521914 1188 5322196
SGTC_1522 st012842 45.6 µM 0.687712097216609 0.227652223930648 no 773 0.245817050241004 1126 3491067 YOR116C RPO31
SGTC_3282 9108498 15.4605 µM 0.687170990146478 0.227810515048708 no 774 0.245987491496217 1180 16459645
SGTC_995 3931-2021 34.6 µM 0.686581214296489 0.227983113863991 no 775 0.246173334939905 1187 730143
SGTC_126 0417-1624 672.48 µM 0.68299102282434 0.229035374293009 no 776 0.247306257582875 1309 41912 YDL195W SEC31
SGTC_2048 5246248 200 µM 0.682226437595276 0.229259820369124 no 777 0.247547889995933 1213 677046
SGTC_91 0417-1751 58.384 µM 0.6821347278528 0.229286750294657 no 778 0.247576881560464 1308 6795624
SGTC_1033 k072-0102 21.3 µM 0.681564912791365 0.22945411224595 no 779 0.247757053880303 1200 5965931
SGTC_644 1498-1197 63.3 µM 0.681294210918866 0.229533644819986 no 780 0.247842672814717 1248 6741615
SGTC_192 3455-0609 60.9 µM 0.678711485901232 0.230293229128108 no 781 0.248660343531926 1267 3769639
SGTC_3212 9128307 49.47 µM 0.677981052294336 0.230508305748974 no 782 0.248891853507644 1171 27243542
SGTC_1885 st057546 99.9 µM 0.676655613861843 0.230898868445668 no 783 0.249312242284016 1268 702008
SGTC_426 0988-0037 14.6 µM 0.676643420730529 0.23090246307098 no 784 0.24931611132616 1244 5383008
SGTC_2085 5307070 144.047 µM 0.676547766696252 0.230930663671931 no 785 0.249346464726244 1191 2840351
SGTC_667 1498-1044 59 µM 0.676515108804887 0.230940292270325 no 786 0.249356828335873 1245 6739982
SGTC_2740 felodipine 17.08 µM 0.671839132314664 0.232321232092402 no 787 0.25084305666906 1188 3333 L-type calcium channel blocker
SGTC_2252 omeprazole 400 µM 0.670726293734223 0.232650558289022 no 788 0.251197454645094 1185 4594 A proton pump inhibitor.
SGTC_1323 1348-1351 11.2 µM 0.670177145388473 0.232813165243577 no 789 0.25137243563197 1194 6989654
SGTC_1731 st035964 63 µM 0.669782612356459 0.232930028411804 no 790 0.251498189656451 1229 6739575
SGTC_1382 3002-2117 298 µM 0.667532320207695 0.233597201669919 no 791 0.252216086062375 1277 1497314
SGTC_397 arbidol 50 µM 0.666046599159 0.234038272745492 no 792 0.252690657809333 1277 131410 A RNA synthesis inhibitor.
SGTC_883 0850-0245 24.6 µM 0.665367110210207 0.234240148567516 no 793 0.252907858032954 1289 6823229 YPR165W RHO1
SGTC_899 1083-0020 478 µM 0.664498626792858 0.234498314835631 no 794 0.253185613769383 1283 767123
SGTC_2073 5212005 126 µM 0.663901541502121 0.234675896290319 no 795 0.253376664796749 1144 691789
SGTC_1475 4092-1048 11.7 µM 0.661462291496196 0.23540213496057 no 796 0.254157944767551 1245 2881759
SGTC_217 ketoconazole 989 nM 0.661391220271511 0.235423313599411 no 797 0.254180727464196 1197 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2409 alverine citrate 63.97 µM 0.660887205538846 0.235573536000498 no 798 0.254342325894171 1358 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1575 cyproterone acetate 48 µM 0.657760223924906 0.236506718663869 no 799 0.25534610858532 1212 9880 An androgen receptor antagonist and liver toxin.
SGTC_2991 9074669 71.4286 µM 0.657492329638711 0.236586760645372 no 800 0.25543220069392 1273 17333109
SGTC_2473 5854593 8.94 µM 0.657378169193023 0.236620874256285 no 801 0.255468892585403 1221 2872951
SGTC_3231 9132313 49.47 µM 0.656750214562278 0.236808569059764 no 802 0.255670770413122 1264 4905967
SGTC_2825 7998094 58.44 µM 0.655439927286724 0.237200475693094 no 803 0.256092275877498 1247 2987815
SGTC_452 diindolylmethane 8 µM 0.65452946191259 0.237473005344031 no 804 0.256385376168609 1244 3071 Inhibits expression of several cancer promoting factors.
SGTC_784 4579-0127 173 µM 0.654442195329835 0.237499135878937 no 805 0.256413478519093 1322 1948547
SGTC_1881 5652484 16 µM 0.65442524630502 0.237504211167123 no 806 0.256418936778879 1223 2255129
SGTC_2891 9063876 19.48 µM 0.651578456539732 0.238357510204112 no 807 0.257336574620169 1232 6472478
SGTC_2070 5230947 200 µM 0.651345906659138 0.238427288991677 no 808 0.257411610374224 1325 2835538
SGTC_27 0485-0001 32.618 µM 0.649747585052334 0.238907182975611 no 809 0.25792764054436 1207 2054479
SGTC_1947 st076332 61.6 µM 0.649553594501976 0.238965464310545 no 810 0.257990308357568 1253 24208416
SGTC_1685 st024049 53.0905 µM 0.648144604250353 0.239389005922061 no 811 0.258445713495245 1261 1941139
SGTC_3155 9099265 49.47 µM 0.647372943459023 0.239621140330443 no 812 0.258695301306412 1237 25236499
SGTC_278 4092-0821 23.9 µM 0.646198587052063 0.239974651060823 no 813 0.259075377240027 1270 877900
SGTC_718 1130-0073 349 µM 0.645388281172442 0.240218739173916 no 814 0.259337797870608 1340 6740020
SGTC_2146 5545642 200 µM 0.645010134589236 0.240332694402607 no 815 0.259460309059181 1289 825326
SGTC_326 k292-0812 17.5 µM 0.64497080497562 0.240344548150868 no 816 0.259473052706219 1250 3579357
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.644020548955998 0.240631047341277 no 817 0.259781054482041 1202 641818 YHR062C RPP1
SGTC_1119 parthenolide 318.541 nM 0.644002427658093 0.240636512661245 no 818 0.25978692988117 1357 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_324 1315-0088 19.6 µM 0.643551032972025 0.240772673520097 no 819 0.259933305977942 1223 6787421
SGTC_1939 st074455 53.6 µM 0.643282407803719 0.240853722798714 no 820 0.260020434640703 1337 1644229
SGTC_3197 9113331 49.47 µM 0.64144832887108 0.241407495430309 no 821 0.260615720926041 1340 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1635 st007035 42.4 µM 0.641345703758027 0.241438501964903 no 822 0.260649050631983 1304 3716403
SGTC_3139 9095020 49.47 µM 0.640700016942895 0.241633635509677 no 823 0.260858801583704 1104 25236292
SGTC_24 0417-1663 219 µM 0.640609022389937 0.241661141930308 no 824 0.260888368084984 1263 4329390
SGTC_557 1315-0110 16.2 µM 0.640372456823082 0.241732660449656 no 825 0.260965242466398 1273 6833801
SGTC_3060 1327-0027 12.5 µM 0.636639404556844 0.242862756590191 no 826 0.262179875999044 1215 16000455 YPR107C YTH1
SGTC_1961 st076550 68.7 µM 0.635549599664923 0.243193208379673 no 827 0.262535014298836 1275 1579337
SGTC_1513 0337-0559 19 µM 0.634907025526881 0.243388164248194 no 828 0.262744527374698 1229 775073
SGTC_721 1187-1332 279 µM 0.632928281945934 0.243989041651057 no 829 0.263390238959252 1237 25730
SGTC_1166 k206-0078 225 µM 0.632383747824452 0.244154538526498 no 830 0.263568075576637 1292 5404595
SGTC_1835 st008666 49.2 µM 0.632244390190699 0.244196902352936 no 831 0.263613597518978 1253 690455
SGTC_4 0960-0234 25.671 µM 0.631469894046467 0.244432416413482 no 832 0.263866664046604 1302 6821112
SGTC_2420 aureobasidin a 50 nM 0.630230385876958 0.244809589026358 no 833 0.264271930767775 1413 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_943 3253-1379 105 µM 0.627959771935145 0.245501330820904 no 834 0.265015146652505 1319 668464
SGTC_1079 idarubicin 2.36 µM 0.626610509654348 0.245912880008058 no 835 0.265457288768703 1284 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_957 1187-1561 14.1 µM 0.624857796283513 0.246448041380876 no 836 0.2660321968317 1272 1538454
SGTC_2946 9065502 71.43 µM 0.624562495902482 0.246538267747765 no 837 0.266129120443431 1156 16489101
SGTC_1086 cerivastatin 2.18 µM 0.623411827505593 0.24689001285649 no 838 0.266506963800833 1286 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1403 3909-7815 62.9 µM 0.623143359670606 0.246972118783425 no 839 0.266595159226387 1288 6615483
SGTC_1848 st056003 16.4 µM 0.622912833509818 0.247042632608146 no 840 0.266670902058375 1347 146492
SGTC_1649 st011737 51.3 µM 0.622296162083644 0.247231314287087 no 841 0.266873572176677 1295 1761035
SGTC_1017 4239-0030 168 µM 0.621757366281256 0.247396231576299 no 842 0.267050712014621 1277 1149593
SGTC_2455 5377712 9.75 µM 0.621260064072221 0.247548500464494 no 843 0.267214262680719 1257 2243908
SGTC_164 4100-3994 89.624 µM 0.621192977011756 0.247569045673551 no 844 0.267236329861176 1348 4615967
SGTC_1428 4049-0204 61.7 µM 0.619761094679721 0.248007772423711 no 845 0.267707543092512 1368 X1428
SGTC_2203 7227154 166.4 µM 0.619429583554352 0.24810940607906 no 846 0.267816698611123 1294 896304
SGTC_143 4032-1194 15.74 µM 0.617712197713098 0.248636272391393 no 847 0.268382535000363 1342 1806963
SGTC_2008 4012253 172 µM 0.617494327076163 0.248703154163445 no 848 0.268454360965981 1328 603940
SGTC_3308 9128332 17.569 µM 0.615883269800002 0.249198012593275 no 849 0.26898578209758 1344 17332805 YDL196W YDL196W
SGTC_523 1934-0222 13.7 µM 0.613909644827694 0.249804951638474 no 850 0.269637518218549 1318 1361595
SGTC_1665 st014639 11.4 µM 0.613823216354316 0.249831548481266 no 851 0.269666076947838 1374 981133 YIL048W NEO1
SGTC_3073 9114972 49.47 µM 0.613743712870274 0.24985601560779 no 852 0.269692348777275 1276 41905075
SGTC_412 gemfibrozil 100 µM 0.612191427723565 0.250333984742335 no 853 0.270205556250894 1306 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2803 7707263 71.43 µM 0.610263287166223 0.250928359047127 no 854 0.270843706211832 1321 2199229
SGTC_1552 6-methylflavone 10.6 µM 0.609354197292007 0.251208856654353 no 855 0.271144845242776 1298 689013
SGTC_2515 chrysin 20.77 µM 0.608773925834464 0.251387984751521 no 856 0.271337149341526 1354 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3004 9076122 71.4286 µM 0.607375669803666 0.251819899489092 no 857 0.271800815581213 1334 44782551
SGTC_666 0272-0154 136 µM 0.606092037756852 0.252216752058993 no 858 0.272226818975494 1345 6870312
SGTC_2296 7971656 126.45 µM 0.605288207082096 0.252465435239678 no 859 0.272493757885571 1339 666570
SGTC_769 0302-0231 76 µM 0.605046475723167 0.252540245560799 no 860 0.272574058296004 1337 571869 YER009W NTF2
SGTC_3011 9081274 71.4286 µM 0.603105477018055 0.253141363365539 no 861 0.273219261550581 1329 6625322
SGTC_2831 7999036 19.48 µM 0.60262135824922 0.253291409755359 no 862 0.273380304255409 1430 2988270
SGTC_1038 k292-0204 154 µM 0.60159595118041 0.253609375837284 no 863 0.273721562319024 1267 4454212
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.600208998288028 0.254039786172573 no 864 0.274183478745469 1329 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2950 9072895 21.46 µM 0.60012287446244 0.254066525439708 no 865 0.274212174465508 1285 17332245
SGTC_1318 1280-3875 124 µM 0.599442071195235 0.254277949570441 no 866 0.274439064466609 1340 373245
SGTC_3096 9117468 49.47 µM 0.599283774212925 0.254327122069211 no 867 0.274491833071692 1255 41316311
SGTC_2437 5741531 144.16 µM 0.598289491943271 0.254636094358513 no 868 0.274823393428289 1455 2262990
SGTC_2953 9074162 66.49 µM 0.597743787397672 0.25480575505781 no 869 0.275005451773206 1358 16451992
SGTC_1903 st060211 78.3 µM 0.597640912438674 0.254837745728641 no 870 0.275039779646422 1375 688960
SGTC_1821 st053465 65.6 µM 0.597358792521246 0.254925486372237 no 871 0.275133929777513 1289 675086
SGTC_547 1120-0019 610 nM 0.597320156750325 0.254937503512382 no 872 0.275146824689293 1357 3676939
SGTC_1739 st037196 92.5 µM 0.596061629362465 0.255329113675349 no 873 0.27556702813562 1377 612214
SGTC_1220 1838-0075 193 µM 0.595901363579342 0.255379005400488 no 874 0.275620561124348 1283 5529645
SGTC_102 gallobenzophenone 83.616 µM 0.595520196745084 0.255497685449006 no 875 0.275747901415444 1425 70837
SGTC_1491 4138-0063 26.5 µM 0.595326986904661 0.255557854238981 no 876 0.275812460038351 1325 23883227
SGTC_697 0508-1955 564 µM 0.595048775691901 0.255644506884814 no 877 0.275905433839096 1343 6243113
SGTC_3215 9129942 49.47 µM 0.592171064073249 0.25654170848402 no 878 0.276868021901389 1306 17682944
SGTC_466 geldanamycin 89.2 µM 0.591846673878373 0.256642948348163 no 879 0.276976632751326 1271 5288382 HSP90 inhibitor.
SGTC_629 3448-6466 76.7 µM 0.591173359725382 0.256853151277258 no 880 0.277202135290752 1339 573744
SGTC_783 0848-0141 92.7 µM 0.589881132769739 0.25725682434713 no 881 0.277635172015202 1345 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2014 4013930 200 µM 0.58929459502487 0.257440159035807 no 882 0.277831835005561 1333 64556
SGTC_1882 5615643 20 µM 0.588956027589088 0.257546016288745 no 883 0.277945385819816 1297 2253075
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.588200582560608 0.257782296897531 no 884 0.278198833207527 1334 279621
SGTC_2226 7298446 200 µM 0.587867970056817 0.257886363801965 no 885 0.278310458478738 1357 3283010
SGTC_2359 9039622 200 µM 0.58778430833282 0.257912543087508 no 886 0.278338538918908 1325 6463596
SGTC_3054 9094397 49.47 µM 0.587377676408828 0.258039805297935 no 887 0.278475041587368 1321 2598354
SGTC_1371 2421-0008 32.7 µM 0.587047454969494 0.25814317753685 no 888 0.278585917938083 1373 2827552
SGTC_141 0443-0274 32.331 µM 0.584326770047278 0.258995674901683 no 889 0.279500242404485 1422 1627241
SGTC_1019 4262-0212 3.4 µM 0.582699055121947 0.259506397136723 no 890 0.280047954709559 1400 4677213
SGTC_1171 0368-0077 21.4 µM 0.581675276305064 0.259827890751727 no 891 0.280392713933959 1336 3239779
SGTC_1867 st057372 64 µM 0.581332015422069 0.259935729726122 no 892 0.280508353592961 1364 688837
SGTC_3132 9126706 49.47 µM 0.580766333717291 0.260113494868901 no 893 0.28069897397988 1376 850858
SGTC_2694 st077685 81.9 µM 0.580296882155663 0.260261067317387 no 894 0.280857214809397 1330 2838096
SGTC_1988 st071872 53.4 µM 0.579285258463244 0.260579218566089 no 895 0.281198355348716 1395 16414116
SGTC_865 0488-0499 301 µM 0.578921288947484 0.260693734351975 no 896 0.281321142364877 1368 9634651
SGTC_1008 4106-0037 6 µM 0.576983187696759 0.261303955295243 no 897 0.281975406406741 1362 2905394
SGTC_2412 st077135 33.4 µM 0.576041655862924 0.261600665935091 no 898 0.282293512933107 1448 13258915
SGTC_1924 st058459 75.1 µM 0.575199189859403 0.261866303872533 no 899 0.282578295316318 1335 688683
SGTC_1786 berberine 21.6 µM 0.57439627395536 0.262119599955022 no 900 0.282849836879191 1338 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2925 9010536 32.5 µM 0.574251583688248 0.262165258778398 no 901 0.282898783623071 1445 2994177
SGTC_310 1273-0058 1.06 µM 0.573423209733913 0.262426740972394 no 902 0.283179089509045 1368 2734232
SGTC_1770 st043884 66.3 µM 0.573171931544204 0.262506085127445 no 903 0.283264143569842 1370 670149
SGTC_2751 anetholtrithion 17.25 µM 0.572806773629039 0.262621410080626 no 904 0.283387766119413 1394 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_470 aa-861 153 µM 0.572782928853218 0.26262894169034 no 905 0.283395839559289 1331 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_38 0929-0051 58.268 µM 0.572726758398807 0.262646684124131 no 906 0.283414858365832 1422 1379719
SGTC_2977 9011197 71.43 µM 0.572638464911591 0.262674574426952 no 907 0.283444754976763 1434 2704722
SGTC_2767 sibutramine 71.45 µM 0.57177707211524 0.262946752186874 no 908 0.283736506120286 1463 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1916 st067606 49.2 µM 0.57083915548231 0.263243273363061 no 909 0.284054339101736 1450 19590279
SGTC_3333 9141820 12.094 µM 0.569992591847801 0.263511059974889 no 910 0.284341361336155 1378 1939433
SGTC_2859 9028643 45.46 µM 0.566886233349744 0.26449485877431 no 911 0.285395738947464 1347 17151580
SGTC_67 0335-0847 266 µM 0.566348226991569 0.264665437684425 no 912 0.28557854107437 1620 4552207 YOR254C SEC63
SGTC_3027 9089541 49.47 µM 0.566076694664253 0.26475155026512 no 913 0.28567082263923 1366 9943819
SGTC_1950 st077106 7.18 µM 0.564576703921719 0.265227507384785 no 914 0.286180857195068 1362 13831864
SGTC_2107 5363541 170.161 µM 0.560883067833956 0.266401372046963 no 915 0.287438626776177 1364 244052
SGTC_1031 k035-0009 16 µM 0.559659925124867 0.266790674318597 no 916 0.287855710995308 1466 5180959
SGTC_3186 9110464 49.47 µM 0.557876603877204 0.267358785086875 no 917 0.288464324339421 1432 17018021
SGTC_772 k072-0172 35.3 µM 0.557474504239452 0.267486965810147 no 918 0.288601636978549 1322 5861980
SGTC_3071 9117417 49.47 µM 0.557138240995637 0.267594183095226 no 919 0.288716490843877 1391 45595590 YGL055W OLE1
SGTC_1498 4478-3555 97.6 µM 0.556811050154353 0.267698528443549 no 920 0.288828266601362 1410 3437919
SGTC_766 1391-0721 126 µM 0.556580035502514 0.267772214321641 no 921 0.288907198673635 1496 1020919 YIL115C NUP159
SGTC_828 2074-0507 139 µM 0.553586625935612 0.268727934129621 no 922 0.289930890486749 1483 X828
SGTC_1516 st013856 110 µM 0.553236453145088 0.268839847282202 no 923 0.290050754277027 1388 5281404 A mutagen and neurotoxin.
SGTC_2298 7976326 193.81 µM 0.55201430578603 0.269230621658543 no 924 0.29046927597661 1321 2235818
SGTC_863 0466-0191 129 µM 0.55192528846737 0.269259095546718 no 925 0.290499770804156 1405 765160 YPR165W RHO1
SGTC_1417 3966-0327 90.4 µM 0.550760096687137 0.269631943594082 no 926 0.290899070804836 1455 651118
SGTC_2544 sphondin 68.51 µM 0.55067901821177 0.269657897401117 no 927 0.290926865160557 1445 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_231 b-estradiol 524 µM 0.550168620381438 0.269821308172621 no 928 0.29110186214638 1346 450 A steroid.
SGTC_739 1486-1183 203 µM 0.547753742879101 0.270595135506062 no 929 0.29193050226738 1440 4346692
SGTC_616 4092-0450 108 µM 0.545086905990118 0.271450987206744 no 930 0.292846873938419 1449 787165
SGTC_3150 9097574 49.47 µM 0.542823920280009 0.272178289535482 no 931 0.293625521019192 1470 17217476
SGTC_3260 9137109 49.47 µM 0.542613439076346 0.272245985416183 no 932 0.293697991987044 1417 17478346
SGTC_1668 st014914 51.6 µM 0.541196379764296 0.272701963872129 no 933 0.294186116263629 1420 2839556
SGTC_2195 6536160 144.242 µM 0.539663602258155 0.273195604175494 no 934 0.294714522746793 1326 3834386
SGTC_747 3448-8087 38.7 µM 0.539342175396682 0.273299177775882 no 935 0.294825386256953 1418 5168703
SGTC_1346 1488-2224 62.4 µM 0.537945922583549 0.273749318900595 no 936 0.295307191546353 1459 3722427
SGTC_1451 4152-0210 104 µM 0.536653936323494 0.274166171683354 no 937 0.295753340047977 1523 659563
SGTC_3124 9127567 49.47 µM 0.536498306601369 0.274216405971187 no 938 0.295807102973274 1517 17592030
SGTC_1846 st056244 14.8 µM 0.535627900478261 0.274497440142014 no 939 0.296107871071406 1462 5393182
SGTC_2113 5491891 107.031 µM 0.535139787996521 0.274655102638121 no 940 0.296276599316594 1411 789979
SGTC_1511 0906-3109 28.5 µM 0.534029629563917 0.275013854952882 no 941 0.296660517336852 1439 2882180
SGTC_513 4245-1575 41.7 µM 0.532824825467126 0.275403453432129 no 942 0.297077423587289 1466 719745
SGTC_1699 st031318 29.054 µM 0.531065790124214 0.275972761349627 no 943 0.297686594763819 1488 5340658
SGTC_467 ro 31-8220 72.8 µM 0.53010075785997 0.276285337257901 no 944 0.298021036829843 1427 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1480 1070-0044 41.2 µM 0.52973665623461 0.276403315628875 no 945 0.29814726454816 1465 3124987
SGTC_2770 toltrazuril 17.5 µM 0.529026520206874 0.276633489188873 no 946 0.298393526437075 1429 68591 Kills coccidiodes.
SGTC_518 1021-0119 62.6 µM 0.528786305230441 0.27671137036898 no 947 0.298476849445774 1393 1097762
SGTC_1389 3405-0187 19 µM 0.527052641679971 0.277273767586409 no 948 0.299078516363205 1385 799890
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.525955447620974 0.277629983918941 no 949 0.299459581194061 1467 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1992 st073643 23.3 µM 0.52573236259785 0.277702438309054 no 950 0.29953708744012 1448 3161292
SGTC_3242 9133940 49.47 µM 0.524959225107562 0.277953612243796 no 951 0.299805768290604 1468 17248444
SGTC_2009 4012297 12.05 µM 0.523680917178309 0.278369147051727 no 952 0.30025024524214 1435 45595307
SGTC_16 erodoxin 22.806 µM 0.523590505710761 0.278398548231704 no 953 0.300281693242518 1462 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2692 st077426 47.7 µM 0.521181762745926 0.279182411413122 no 954 0.301120078687924 1485 25238571
SGTC_3040 9091894 49.47 µM 0.520799972676847 0.279306753558903 no 955 0.301253061065552 1416 25236966
SGTC_2787 5284540 71.43 µM 0.520762017478788 0.279319116353334 no 956 0.301266282793197 1475 736958
SGTC_2187 6125751 200 µM 0.520377427959393 0.279444400122163 no 957 0.301400269638576 1461 874498
SGTC_1915 st067105 30.6 µM 0.519550645515994 0.279713824893891 no 958 0.3016884025119 1402 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2024 5144227 134 µM 0.518949490418854 0.27990980327486 no 959 0.301897982213788 1509 3475211
SGTC_1666 st014829 29 µM 0.518248529666008 0.280138402656327 no 960 0.302142439570446 1442 3858230
SGTC_737 1950-0117 57.9 µM 0.517988174142157 0.280223333600991 no 961 0.302233260180956 1464 5393513
SGTC_1105 epirubicin 18.1 µM 0.517759686433563 0.280297879176196 no 962 0.302312974336355 1400 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_750 4073-0104 132 µM 0.517186813360103 0.280484824895741 no 963 0.302512878157078 1352 22330957
SGTC_3190 9110366 49.47 µM 0.514140742334886 0.281479861838614 no 964 0.303576797081151 1504 17123768
SGTC_1027 k015-0025 8.67 µM 0.512825007762116 0.281910188947134 no 965 0.304036867462778 1418 3598955
SGTC_3140 9094243 49.47 µM 0.511407011640466 0.282374316517668 no 966 0.304533043100967 1456 19291112
SGTC_1399 3562-5772 25 µM 0.51139102151094 0.282379552378907 no 967 0.304538640312969 1429 23847490
SGTC_491 tetrandrine 80.3 µM 0.510922469784072 0.282532997246259 no 968 0.304702673268476 1524 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_946 3434-1334 87.4 µM 0.510687805823485 0.282609861840677 no 969 0.304784840374876 1534 4047976
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.51011784911051 0.282796594010914 no 970 0.304984450551854 1474 756377
SGTC_2257 7960413 200 µM 0.509869083575979 0.282878114439445 no 971 0.305071591388472 1529 2974689 YIL048W NEO1
SGTC_988 1497-1057 103 µM 0.509418051575121 0.283025946332145 no 972 0.305229612946962 1523 3533044
SGTC_2595 hexamethylquercetagetin 100 µM 0.50887218222271 0.283204912045562 no 973 0.305420909861688 1479 386331
SGTC_2639 lactacystin 53 µM 0.506928022556994 0.283842754120034 no 974 0.3061026613516 1534 3870 A proteasome inhibitor.
SGTC_2383 9036125 200 µM 0.506535196256598 0.283971716476584 no 975 0.306240494037763 1488 79580
SGTC_3144 9087057 49.47 µM 0.505647679684485 0.284263185664048 no 976 0.306552001833565 1525 17249618
SGTC_184 1494-0393 24.714 µM 0.505561381861008 0.284291534346823 no 977 0.306582298808583 1433 3090647
SGTC_2843 9000894 45.46 µM 0.505559691247305 0.284292089723938 no 978 0.306582892353337 1375 2242070
SGTC_1817 st052116 64.4 µM 0.505211530388894 0.284406473779918 no 979 0.306705136318817 1519 4361398
SGTC_1259 0671-0132 43 µM 0.504709491241612 0.284571451399507 no 980 0.306881446881286 1466 X1259
SGTC_561 1550-0330 72.9 µM 0.503711705560634 0.284899474398699 no 981 0.307231990721184 1441 6812934
SGTC_110 0850-0284 111.64 µM 0.503039487634819 0.285120568327806 no 982 0.307468254890244 1367 3906265
SGTC_1808 st050063 61.5 µM 0.502776736752612 0.285207009887057 no 983 0.307560625564245 1521 4011993
SGTC_3093 9117344 49.47 µM 0.502718761727314 0.285226084583937 no 984 0.307581008460627 1468 24824913
SGTC_1278 0874-0585 172 µM 0.501716988958461 0.285555779573735 no 985 0.307933306146502 1498 766306
SGTC_354 2783-3500 4.88 µM 0.501666860772651 0.285572282103065 no 986 0.307950939593812 1408 6740761
SGTC_1980 st071811 45.7 µM 0.501514439427268 0.285622463003263 no 987 0.308004559134727 1519 4974850
SGTC_247 mechlorethamine 29.705 µM 0.500784935904524 0.285862691800651 no 988 0.308261244260555 1462 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1051 3253-3903 78 µM 0.50054358587686 0.285942190596925 no 989 0.308346187001252 1445 5509239
SGTC_786 4544-0069 423 µM 0.50034953443369 0.286006117233307 no 990 0.308414490526589 1535 748821 YLR208W SEC13
SGTC_2967 9089538 49.85 µM 0.498502221152058 0.286615020054448 no 991 0.309065052028226 1634 728216
SGTC_344 k064-0035 6.43 µM 0.495624702873438 0.287564717142629 no 992 0.310079610361588 1447 5088750
SGTC_1456 k015-0012 13 µM 0.494316907773808 0.287996833426029 no 993 0.310541193059677 1653 2989616
SGTC_2278 7948257 134.34 µM 0.494147240801599 0.288052916545049 no 994 0.310601098440009 1534 1247028
SGTC_2754 granisetron 64.02 µM 0.493797460657706 0.288168552019836 no 995 0.31072461335502 1579 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1745 st081495 74 µM 0.486110873971584 0.290715208474289 no 996 0.31344427879826 1508 13842402 YBL026W LSM2
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.485724615002583 0.290843457873959 no 997 0.313581214499755 1527 4213774
SGTC_1341 1486-1360 280 µM 0.485345124492586 0.290969485695833 no 998 0.313715775684028 1475 3976547
SGTC_2878 9043973 25.97 µM 0.484938238310469 0.291104639889782 no 999 0.313860078464101 1573 6465167
SGTC_1217 1183-1422 255 µM 0.483722383218648 0.291508681532247 no 1000 0.314291452860514 1595 2849664
SGTC_1753 st043925 64 µM 0.482881514312921 0.291788264155718 no 1001 0.314589934023766 1541 670181
SGTC_971 1315-0384 26.7 µM 0.482600075865524 0.291881868233239 no 1002 0.31468986261977 1479 6769120
SGTC_2196 6573537 42.6665 µM 0.47901894886539 0.293074140534391 no 1003 0.315962574188341 1599 2903087
SGTC_1302 1159-0335 255 µM 0.477874013158768 0.293455802446977 no 1004 0.316369939221184 1496 649284
SGTC_2400 5203494 178.7 µM 0.474697273478609 0.294515965689966 no 1005 0.317501380793879 1478 6777674
SGTC_1120 ficusin 1.78878 µM 0.473760196179175 0.294829030776258 no 1006 0.317835460888182 1629 6199 A DNA cross-linker.
SGTC_2586 curcumin 80 µM 0.472347247675003 0.29530136793045 no 1007 0.318339475585005 1591 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1142 3253-1408 9.78 µM 0.471466969525554 0.29559581368336 no 1008 0.318653650918996 1519 256655
SGTC_1555 citronellol 128 µM 0.471193776815872 0.295687221819209 no 1009 0.318751181184618 1613 8842 A terpine precursor.
SGTC_496 calpeptin 138 µM 0.471145594284731 0.295703344663352 no 1010 0.31876838373346 1468 73364 A calpain inhibitor.
SGTC_3204 9114183 49.47 µM 0.468419947401456 0.296616058003717 no 1011 0.319742152984465 1504 17027248
SGTC_2427 5545055 42.75 µM 0.467354483440148 0.296973190993012 no 1012 0.320123140967626 1574 5372858
SGTC_2428 5615643 7.78 µM 0.467100574278166 0.297058327849976 no 1013 0.320213961669688 1562 2253075
SGTC_3116 9124943 49.47 µM 0.466973446174829 0.297100958654207 no 1014 0.320259438135061 1439 41905195 YPL160W CDC60
SGTC_1828 st055811 49 µM 0.463259333241997 0.298347672244473 no 1015 0.321589245719183 1593 5877589
SGTC_2890 9046729 58.44 µM 0.46315456476369 0.298382874314253 no 1016 0.321626790488703 1455 903329
SGTC_54 0159-0055 9 µM 0.462332519509707 0.298659146012613 no 1017 0.321921441339517 1646 3319099
SGTC_3158 9100007 49.47 µM 0.461871448194581 0.298814153042267 no 1018 0.322086755070051 1504 19297233
SGTC_2189 6047310 154.431 µM 0.461254604263151 0.299021586239201 no 1019 0.322307974982386 1498 711535
SGTC_1340 1486-1359 257 µM 0.456585912798375 0.300593696460129 no 1020 0.323984353261605 1560 4309068
SGTC_429 1112-0049 25.5 µM 0.456561617345427 0.300601887333653 no 1021 0.323993086365731 1490 2836170
SGTC_1800 st050079 29.0735 µM 0.456123077418658 0.30074975228234 no 1022 0.324150738063029 1515 3645560
SGTC_1911 st060208 74.3 µM 0.455483421048673 0.300965487608425 no 1023 0.324380746102502 1636 688783
SGTC_1152 3909-8331 15.9 µM 0.454640865456443 0.30124976068417 no 1024 0.324683815044545 1543 16001939
SGTC_337 1315-0038 354 µM 0.454284488864461 0.301370036337694 no 1025 0.324812039375371 1533 1626437
SGTC_246 cycloheximide 667 µM 0.452523884392881 0.30196455015132 no 1026 0.325445809408453 1506 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_875 0709-0210 25.7 µM 0.450115679513802 0.302778595026476 no 1027 0.326313515789772 1595 6251364
SGTC_2338 7999974 200 µM 0.447874654940238 0.303537009591052 no 1028 0.32712183044606 1680 315925
SGTC_2848 9016370 25.97 µM 0.447500542085304 0.303663700629309 no 1029 0.327256848279904 1658 7894410
SGTC_489 paxilline 115 µM 0.446747587403888 0.303918755673072 no 1030 0.327528659158505 1510 105008 A toxic potassium channel blocker.
SGTC_659 k018-0002 107 µM 0.446056756735307 0.304152850896394 no 1031 0.327778124187818 1660 6797879 YHR007C ERG11
SGTC_2290 7904846 200 µM 0.445403243399553 0.304374374666925 no 1032 0.328014184368539 1538 2962154
SGTC_639 0833-0042 114 µM 0.44518645658617 0.304447875536636 no 1033 0.328092506652315 1530 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1334 1486-0610 236 µM 0.444901680500461 0.304544439951979 no 1034 0.328195404071314 1581 3742339
SGTC_1983 st071813 46.9 µM 0.444147802318429 0.304800137448654 no 1035 0.328467863881479 1565 11838595
SGTC_2699 st077704 54.6 µM 0.444046212389187 0.304834601623956 no 1036 0.328504586570705 1578 645852
SGTC_2205 7238770 200 µM 0.442880006433016 0.305230358587013 no 1037 0.328926264846091 1600 279867
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.441594699836464 0.305666796770436 no 1038 0.329391260025457 1524 688669
SGTC_2246 7293507 91.5585 µM 0.438729202454456 0.306640797603505 no 1039 0.330428882341047 1710 887656
SGTC_713 1488-1073 324 µM 0.435055764835723 0.307891421857834 no 1040 0.331760975348687 1599 3312542
SGTC_1709 st033179 39.1045 µM 0.43501326217652 0.307905905021088 no 1041 0.33177640051877 1562 573381
SGTC_831 k061-1017 217 µM 0.435002755948874 0.307909485158746 no 1042 0.331780213508827 1652 1240153
SGTC_1888 azatryptophan 97.5 µM 0.433349014539604 0.308473247446099 no 1043 0.33238061737879 1552 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1676 st018489 23.4 µM 0.432398185196369 0.308797590922321 no 1044 0.332726018446208 1585 3696235
SGTC_749 1000-0129 128 µM 0.43104207788188 0.30926043944395 no 1045 0.333218887670788 1720 708470
SGTC_203 k066-0004 30.888 µM 0.429430210800809 0.309810974397215 no 1046 0.333805086055286 1650 6795412
SGTC_1569 carminic acid 40.6 µM 0.42849317834724 0.310131215133526 no 1047 0.334146049505184 1656 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_790 1575-0012 79.1 µM 0.424251903145421 0.311582514635605 no 1048 0.335691055917885 1629 378741 YLR208W SEC13
SGTC_2670 beta-carotene 100 µM 0.423816827607842 0.311731557014585 no 1049 0.335849702433399 1600 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_794 k038-0031 316 µM 0.421747618241374 0.312440821021278 no 1050 0.336604621676694 1577 6624242
SGTC_2341 7987486 176.74 µM 0.421073903631031 0.312671900736328 no 1051 0.336850558461598 1750 1258686
SGTC_225 nsc-122657 1.016 µM 0.420966456944847 0.312708761060639 no 1052 0.336889787892459 1622 275685
SGTC_1938 st074717 56.4 µM 0.420656168574385 0.312815218133278 no 1053 0.3370030860012 1537 17250979
SGTC_2471 5466956 24.79 µM 0.418207667171896 0.313655823478539 no 1054 0.337897645250428 1634 724419
SGTC_1687 st020778 55.3625 µM 0.416729016174624 0.314163934732869 no 1055 0.338438314079866 1626 4259299
SGTC_3056 9094900 49.47 µM 0.416309075558708 0.314308303910975 no 1056 0.338591926198283 1520 25236784
SGTC_2643 anethole 100 µM 0.411964773219603 0.315803472628917 no 1057 0.340182621629401 1605 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2676 harmalol 100 µM 0.411464822770046 0.315975733611579 no 1058 0.340365865137438 1666 5459187 A monoamine oxidase inhibitor
SGTC_2882 9058044 58.44 µM 0.411443910983439 0.315982939766494 no 1059 0.340373530616967 1525 18076804
SGTC_2453 5731132 22.18 µM 0.410072218871724 0.316455774411885 no 1060 0.340876485606671 1748 1362040
SGTC_2847 9005661 71.43 µM 0.408430346659115 0.317022137243654 no 1061 0.341478878891953 1599 2991449
SGTC_358 0075-0058 9.45 µM 0.407285694344574 0.317417238236484 no 1062 0.341899084255791 1857 1069125
SGTC_86 0417-1630 471.922 µM 0.406517946958523 0.317682359151178 no 1063 0.342181036484573 1637 3634867
SGTC_762 1165-0429 115 µM 0.406355447645944 0.317738485914964 no 1064 0.342240725012678 1710 5967793
SGTC_674 0498-0004 451 µM 0.406224758523347 0.317783628575729 no 1065 0.342288732022357 1584 4231473
SGTC_1461 k072-0203 53.8 µM 0.404446027034172 0.318398307409868 no 1066 0.342942379845053 1573 5418714
SGTC_1806 st050005 60.3 µM 0.403957709588068 0.318567143575652 no 1067 0.343121908993563 1591 5194765
SGTC_1579 chlormadinone acetate 49.4 µM 0.403373643975826 0.318769134234011 no 1068 0.343336686318153 1729 45114258 A steroidal progestin.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.402169953535936 0.319185582996425 no 1069 0.343779476637559 1678 5377381
SGTC_1667 st014849 34.6 µM 0.401839339350753 0.319300007760468 no 1070 0.343901134133585 1631 5348460
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.401140013469835 0.319542099447246 no 1071 0.344158521268587 1652 66535 A nucleotide analog.
SGTC_2917 7979103 53.79 µM 0.400742204032503 0.319679846913229 no 1072 0.344304967401127 1716 2980565
SGTC_3100 9120536 49.47 µM 0.39963815993498 0.320062268971857 no 1073 0.344711522922137 1692 16421196
SGTC_382 3229-0966 23.2 µM 0.399075172918834 0.320257351738283 no 1074 0.344918907544486 1712 5722370
SGTC_893 0958-0369 48.9 µM 0.398195037099132 0.320562430489527 no 1075 0.345243211983857 1762 6819948
SGTC_1645 Cervolide 78 µM 0.396712304348221 0.321076659705934 no 1076 0.345789812816581 1623 23173 A fragrance.
SGTC_3076 9116187 49.47 µM 0.394372314801269 0.321888893888063 no 1077 0.346653090285604 1763 27241210
SGTC_2444 5485484 36.41 µM 0.394076085829732 0.321991778794575 no 1078 0.346762433075774 1706 6790631
SGTC_366 0181-0206 4.31 µM 0.390936763893847 0.323082951157621 no 1079 0.347921989228869 1808 274874
SGTC_1795 st049545 62.3 µM 0.39059272837463 0.323202624611709 no 1080 0.348049150715218 1754 5291882
SGTC_2973 9094665 17.96 µM 0.390323365057789 0.323296335961852 no 1081 0.348148723990655 1754 25237061 YIL048W NEO1
SGTC_2520 obtusaquinone 4.71 µM 0.389682355186758 0.323519388026298 no 1082 0.348385722817962 1728 5967872
SGTC_862 0452-0056 10.2 µM 0.38832953116294 0.323990338019769 no 1083 0.348886092978793 1654 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2647 atorvastatin 60.16 µM 0.388020749404026 0.324097871778782 no 1084 0.34900033923253 1700 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_848 0368-0089 85.6 µM 0.386879182362653 0.324495551772935 no 1085 0.349422826739815 1706 762535
SGTC_3323 9138564 53.9225 µM 0.386187286329316 0.324736680398783 no 1086 0.349678984417336 1770 43912313 YNL103W MET4
SGTC_118 0083-0097 135.343 µM 0.385333619656314 0.325034287994855 no 1087 0.349995128062106 1656 5207356
SGTC_1115 galangin 695.678 nM 0.384746300267247 0.325239105734673 no 1088 0.350212694082184 1748 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3318 9139014 38.6185 µM 0.38376050424904 0.325583004164681 no 1089 0.350577981886855 1649 16643984
SGTC_1664 st014217 9.02 µM 0.382937497097015 0.325870226894911 no 1090 0.350883053975652 1707 3982782
SGTC_2207 7258803 200 µM 0.382809978089669 0.325914739233586 no 1091 0.350930331298467 1710 3666799
SGTC_2087 5276107 200 µM 0.381056667782504 0.326527008709708 no 1092 0.351580600029618 1625 144405
SGTC_2269 7935389 174.42 µM 0.380840693115972 0.326602461108886 no 1093 0.351660730936455 1589 97605
SGTC_2860 9025725 38.96 µM 0.380463938578608 0.326734100162545 no 1094 0.351800530156377 1593 40546248
SGTC_3152 9099253 49.47 µM 0.380168839617844 0.326837223603486 no 1095 0.351910044107219 1722 25236131
SGTC_3287 9117173 37.0625 µM 0.379614627819934 0.327030930743367 no 1096 0.35211575042537 1657 2789709
SGTC_2823 7987624 58.44 µM 0.379598475292884 0.327036577045678 no 1097 0.352121746394374 1652 2239440
SGTC_1559 coumarin 343 70.1 µM 0.378099477222606 0.327560741308083 no 1098 0.352678348328492 1721 108770 A hepatotoxic, DNA x-linker.
SGTC_1336 1486-0901 104 µM 0.376441719614427 0.328140816034547 no 1099 0.353294267627021 1698 5006114
SGTC_844 0330-0132 15.3 µM 0.375783656291278 0.328371197515179 no 1100 0.353538869587135 1731 2828079
SGTC_1106 tegaserod maleate 11.7 µM 0.375373352206015 0.32851487397486 no 1101 0.353691410129229 1691 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3179 9107801 49.47 µM 0.371326417087972 0.329933347724364 no 1102 0.355197212126747 1644 4818259
SGTC_1002 4049-0206 172 µM 0.370935850323735 0.330070373485111 no 1103 0.355342656140584 1625 4662749
SGTC_2109 5483026 200 µM 0.368768768802987 0.330831082353463 no 1104 0.356150042692661 1695 759335
SGTC_1050 3232-1156 69.3 µM 0.368189370359566 0.331034586694093 no 1105 0.356366017861315 1646 700529
SGTC_3069 9117009 49.47 µM 0.36747481800714 0.331285630414744 no 1106 0.356632436123949 1693 41904981
SGTC_1300 1094-0077 113 µM 0.367206581031575 0.331379889712043 no 1107 0.356732465379271 1646 5532636
SGTC_3086 9117350 49.47 µM 0.367008604153268 0.331449466247498 no 1108 0.356806299998788 1640 2679265
SGTC_532 1548-0774 215 µM 0.36551338501843 0.331975130324779 no 1109 0.357364108592565 1789 5932993
SGTC_2461 5755302 26.15 µM 0.362315815908973 0.333100387469663 no 1110 0.358558020277846 1799 2788904
SGTC_343 4130-2827 29.8 µM 0.361570068655619 0.333363040226191 no 1111 0.358836667582264 1648 1118244
SGTC_2971 9092186 9.93 µM 0.360927213560782 0.333589519882485 no 1112 0.359076929704266 1559 25236400
SGTC_1052 3253-3998 198 µM 0.360511672040473 0.333735948611047 no 1113 0.359232264807589 1658 5450317
SGTC_237 nikkomycin 200 µM 0.360472007894417 0.333749926807083 no 1114 0.359247093024905 1771 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3345 9148410 3.559 µM 0.357367477926744 0.334844720754038 no 1115 0.360408360141421 1781 4903596
SGTC_702 1488-0190 94 µM 0.356993945351013 0.33497653967059 no 1116 0.360548169203522 1830 949357
SGTC_379 3970-0972 5.9 µM 0.35660962038341 0.335112188422904 no 1117 0.360692037197377 1721 2898042 YBL034C STU1
SGTC_222 nsc-310342 10.666 µM 0.356380734378874 0.335192984705797 no 1118 0.360777727626624 1799 432556
SGTC_1064 honokiol 6.76 µM 0.356049669331458 0.335309863468817 no 1119 0.360901684251092 1705 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.353449873214324 0.336228245444084 no 1120 0.361875600998407 1734 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1291 0993-0025 5.79 µM 0.352625750843484 0.336519572402294 no 1121 0.362184514905683 1791 4353356
SGTC_1958 st076513 41.9 µM 0.352306068316963 0.336632606492448 no 1122 0.362304368835891 1664 732122 YGL099W LSG1
SGTC_2121 5257820 149.641 µM 0.351813815706977 0.33680668717664 no 1123 0.362488948356425 1825 791256
SGTC_2910 7948405 25.97 µM 0.349096741535002 0.337768184209983 no 1124 0.363508341379858 1834 2971328
SGTC_3168 9103419 49.47 µM 0.34873983233013 0.337894563334013 no 1125 0.363642318748908 1763 16649256
SGTC_3118 9124250 49.47 µM 0.348588652072468 0.337948100746896 no 1126 0.3636990741584 1692 1504786
SGTC_3105 9121040 49.47 µM 0.348167267024848 0.33809734298939 no 1127 0.363857284413529 1749 41448907
SGTC_2984 9022109 38.96 µM 0.34757117474259 0.338308504873939 no 1128 0.364081128652322 1735 6459207
SGTC_1247 0448-0043 5.84 µM 0.346935469342744 0.338533755499271 no 1129 0.364319899492771 1710 3089013 YGL099W LSG1
SGTC_2923 7992654 58.14 µM 0.346089798098585 0.338833493241557 no 1130 0.364637615086007 1695 2985126
SGTC_1090 efavirenz 20.7 µM 0.345726486295236 0.338962295988405 no 1131 0.364774138573381 1765 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1719 st032227 49.2 µM 0.34568050935529 0.338978597258592 no 1132 0.364791416780059 1639 3125804
SGTC_2027 5150920 200 µM 0.344284337943521 0.339473757738884 no 1133 0.365316230836953 1774 786715
SGTC_3326 9140064 16.379 µM 0.344031966403714 0.339563292416285 no 1134 0.365411123027764 1648 1868434
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.343917198671212 0.339604011936116 no 1135 0.365454278644563 1727 4000243
SGTC_414 piperonyl butoxide 100 µM 0.343568074060386 0.339727892638989 no 1136 0.365585568940608 1672 5794 A potent inhibitor of cytochrome P450.
SGTC_871 0574-0004 149 µM 0.343412633381804 0.339783053589977 no 1137 0.365644028359828 1716 9551173
SGTC_1192 1488-0095 21.4 µM 0.343160049988077 0.3398726947168 no 1138 0.365739028671716 1725 915875
SGTC_2932 9016711 44.54 µM 0.340613887228521 0.340776825597223 no 1139 0.366697136745244 1867 7117328
SGTC_276 colchicine 750 µM 0.339459056588823 0.34118720282268 no 1140 0.36713196798292 1731 2833 A microtubule depolymerizer.
SGTC_857 0438-0306 1.35 µM 0.337758079513496 0.34179199916885 no 1141 0.367772751449378 1732 4686136
SGTC_3162 9099653 49.47 µM 0.337682763462902 0.341818787812432 no 1142 0.367801132656141 1792 25237511
SGTC_84 0443-0269 128.823 µM 0.337409234816859 0.341916084017489 no 1143 0.367904212015253 1763 6150058
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.337387759141892 0.341923723521891 no 1144 0.36791230553323 1721 88881 An O-methylated flavonoid and antioxidant.
SGTC_2536 dehydroabietamide 32.04 µM 0.337046893537843 0.342044987713294 no 1145 0.368040775091608 1831 3983547
SGTC_2312 7706453 155.7 µM 0.337029214189171 0.342051277651135 no 1146 0.368047438701467 1699 976098
SGTC_2909 7941780 10.49 µM 0.336929990975895 0.342086579982337 no 1147 0.368084838145238 1861 1243215
SGTC_2130 NSC 7 2.4545 µM 0.336866742440893 0.342109083710431 no 1148 0.368108678582349 1829 21448
SGTC_787 4152-0075 138 µM 0.336328485099768 0.342300617502952 no 1149 0.3683115858884 1740 9566539
SGTC_3353 9151644 39.2805 µM 0.334529547243643 0.342941046703654 no 1150 0.368989999212301 1738 4909158
SGTC_2711 st079103 59.1 µM 0.334392695530854 0.342989784973966 no 1151 0.369041625309095 1823 54693780
SGTC_1426 4048-4480 71.7 µM 0.332900798262059 0.343521277524713 no 1152 0.36960458342575 1808 14224343
SGTC_849 0386-0493 241 µM 0.332089215674698 0.343810536142023 no 1153 0.369910946565813 1723 726119
SGTC_364 0083-0097 67.7 µM 0.331637821495035 0.343971458503986 no 1154 0.370081378453651 1730 5207356
SGTC_2295 7971645 200 µM 0.329117687457833 0.344870406885931 no 1155 0.37103336782405 1799 2978226 YKL099C UTP11
SGTC_925 2064-1272 59.6 µM 0.327978729181786 0.345276968663521 no 1156 0.371463872758813 1704 6815817
SGTC_901 1112-0062 60.1 µM 0.327059524711369 0.345605217544436 no 1157 0.371811432176316 1735 1908457
SGTC_2666 tannic acid 100 µM 0.326512655271474 0.345800560305277 no 1158 0.37201825799251 1761 16134267 A thiamine antagonist.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.326356538410507 0.345856333067986 no 1159 0.372077308109772 1712 6857784
SGTC_1716 st033144 30.6155 µM 0.325925388412629 0.34601037881513 no 1160 0.37224040322316 1863 674617
SGTC_746 1095-0025 46.6 µM 0.325517898508545 0.346155994468009 no 1161 0.372394569281631 1813 6749286
SGTC_851 0394-0702 453 µM 0.320984133982447 0.34777765584909 no 1162 0.374111207245306 1869 762646
SGTC_1205 4161-2785 76 µM 0.318098074171819 0.348811412105057 no 1163 0.375205272205803 1661 3498106
SGTC_172 1112-0046 2.638 µM 0.31777833400787 0.34892600892745 no 1164 0.375326543215475 1745 2802135 YIL048W NEO1
SGTC_2504 purpurogallin 52.29 µM 0.316972083571927 0.349215035162998 no 1165 0.375632392467363 1721 5281571 An antioxidant.
SGTC_536 3852-0578 10.6 µM 0.316683314223174 0.349318575049075 no 1166 0.375741955479443 1862 2869208
SGTC_609 0986-0026 86.3 µM 0.315626517423503 0.349697591098838 no 1167 0.376143003905959 1813 2848610
SGTC_1630 st005209 31.3 µM 0.315136059977014 0.349873542684287 no 1168 0.376329175221111 1900 3367314
SGTC_2684 capsaicin 100 µM 0.315034324517915 0.349910044314456 no 1169 0.37636779629307 1787 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_867 0518-0118 155 µM 0.314878135055619 0.349966086176952 no 1170 0.376427091740118 1868 6848158
SGTC_1190 1486-1332 13 µM 0.309662507769825 0.351839359429941 no 1171 0.378408808328981 1723 4150046
SGTC_3189 9110682 49.47 µM 0.308134893645726 0.352388709812753 no 1172 0.378989845409344 1758 17122418
SGTC_916 4466-0038 42 nM 0.3077363893615 0.352532067973616 no 1173 0.379141463914314 1921 5722064 YGL116W CDC20
SGTC_1413 3910-0535 34.4 µM 0.306958378954199 0.35281201024332 no 1174 0.379437526283182 1845 2876951
SGTC_553 k007-0256 45.7 µM 0.304530094708337 0.353686263041108 no 1175 0.3803620342703 1792 6287000
SGTC_2724 maprotiline 69.64 µM 0.302901445858952 0.354273056882264 no 1176 0.3809824847257 1833 4011 A tricyclic antidepressant.
SGTC_3301 9125354 19.7965 µM 0.301050552372419 0.354940344529232 no 1177 0.381687973142142 1733 41905162
SGTC_166 k072-0058 166.424 µM 0.300932892533332 0.354982778550453 no 1178 0.381732833800266 1896 5846229
SGTC_1218 1348-1416 30.7 µM 0.300182815422762 0.355253336129011 no 1179 0.382018856148663 1750 6787668
SGTC_3303 9125618 40.5795 µM 0.300046783188982 0.355302411641724 no 1180 0.382070735398017 1859 22695467
SGTC_3252 9135871 49.47 µM 0.299635536571971 0.355450789146043 no 1181 0.382227587318045 1840 17682838
SGTC_921 1561-0023 372 µM 0.29819858948341 0.355969410603424 no 1182 0.382775799139519 1719 24050882
SGTC_474 dl-dihydrosphingosine 5 µM 0.298037871412409 0.356027433399438 no 1183 0.382837129558081 1856 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2063 5246145 200 µM 0.29765660029925 0.356165094082145 no 1184 0.382982635318813 1837 711240
SGTC_2717 st081029 62.2815 µM 0.293681387254503 0.35760148721237 no 1185 0.384500689137185 1915 5292846
SGTC_158 k038-0087 26.446 µM 0.293621450094504 0.357623160252551 no 1186 0.384523591556887 1804 X158
SGTC_2766 oltipraz 83.91 µM 0.292443584669146 0.358049164818146 no 1187 0.384973744097104 1882 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3112 9123419 49.47 µM 0.292317645668835 0.358094724287717 no 1188 0.385021884216827 1823 17015854
SGTC_2067 5224629 34.075 µM 0.291320950115802 0.358455358340423 no 1189 0.385402933049969 1750 2835000
SGTC_1581 himbacine 57.9 µM 0.291314303495397 0.358457763709287 no 1190 0.385405474505607 1754 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1921 5740136 50 µM 0.2907933037479 0.35864632760824 no 1191 0.385604703493327 1941 1774243
SGTC_3225 9130819 49.47 µM 0.290772502139011 0.358653856988818 no 1192 0.385612658603034 1865 4547121
SGTC_2385 9074692 200 µM 0.286553563181261 0.36018208203402 no 1193 0.387227087513551 1772 17046906
SGTC_1789 tunicamycin 25 nM 0.282338748126537 0.361711047572982 no 1194 0.388841888452345 1934 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2331 7980721 200 µM 0.282307532024004 0.361722379796207 no 1195 0.388853855326644 1886 2981221
SGTC_2594 a-mangostin 100 µM 0.282188033603232 0.361765761821814 no 1196 0.388899666715115 1918 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2808 7946468 45.46 µM 0.281789199611343 0.361910565098035 no 1197 0.389052576474681 1847 2970879
SGTC_900 1112-0045 141 µM 0.281365246077664 0.362064510117105 no 1198 0.389215135708723 1906 56211 YIL048W NEO1
SGTC_1510 1123-0200 71.5 µM 0.281096616454961 0.362162065831589 no 1199 0.389318148133438 1909 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3131 9127911 49.47 µM 0.280195792876204 0.362489274856198 no 1200 0.389663647124143 1838 45595681
SGTC_922 1866-0035 480 µM 0.278940497887622 0.362945407175363 no 1201 0.390145244337097 1815 3156169
SGTC_2669 eugenol 100 µM 0.278013979817114 0.363282197733257 no 1202 0.390500813647821 1920 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_197 4544-0043 41.561 µM 0.276964973503916 0.363663640538427 no 1203 0.390903500752956 1829 896523
SGTC_2839 9003951 25.97 µM 0.27583929126711 0.364073114832221 no 1204 0.391335751957908 1950 2990634
SGTC_530 4358-1714 28 µM 0.275689748540889 0.364127523670286 no 1205 0.39139318504554 1873 1564641
SGTC_493 zm226600 134 µM 0.275402815877005 0.364231927407862 no 1206 0.391503390473873 1860 5240098 A potassium channel opener. YCR052W RSC6
SGTC_968 1309-0633 340 µM 0.27400551778621 0.364740494203593 no 1207 0.392040190652102 1934 3761976
SGTC_930 2810-3379 265 µM 0.273832339374829 0.364803541586318 no 1208 0.392106734960579 1961 1015764
SGTC_2307 7538926 6.34 µM 0.26947757437709 0.366390136374664 no 1209 0.393781098596955 1808 96582
SGTC_92 0063-0024 660.874 µM 0.268516527218525 0.366740588739775 no 1210 0.394150877476664 1947 3594437
SGTC_1946 st076057 65.1 µM 0.266945002407485 0.367313895208026 no 1211 0.394755753268554 1827 953009
SGTC_1824 st053723 68.6 µM 0.266208931627336 0.367582522328221 no 1212 0.395039152350816 1777 675225
SGTC_2215 7188065 200 µM 0.263732323753706 0.368486829069867 no 1213 0.395993093157849 1928 940217
SGTC_1024 4507-0395 26 µM 0.263593371672804 0.368537587569627 no 1214 0.396046633292305 1849 4201836
SGTC_2588 indole-3-carbinol 100 µM 0.262595226941001 0.368902272220671 no 1215 0.396431289670136 1967 3712 Induces cell cycle arrest.
SGTC_1811 st050069 61.5 µM 0.26222813582515 0.369036423259455 no 1216 0.396572781447603 1995 3877702
SGTC_1929 genistein trimethyl ether 50.5 µM 0.26066271167751 0.369608676142224 no 1217 0.397176311963411 2006 136420
SGTC_2874 9043904 71.43 µM 0.258710513979614 0.370322721828874 no 1218 0.397929303352131 1831 4463428
SGTC_1920 st075728 45.7 µM 0.258134114136103 0.370533634346276 no 1219 0.398151702115131 1988 3400306
SGTC_1433 4060-0023 7.6 µM 0.257548813962214 0.370747843441527 no 1220 0.398377568854504 1912 3840627
SGTC_2396 5342950 42.78 µM 0.255660753488101 0.37143911163897 no 1221 0.399106401178634 1838 1886677
SGTC_506 n9-isopropylolomoucine 153 µM 0.255180406455503 0.371615045506784 no 1222 0.399291881807264 2023 6610355
SGTC_3281 9140613 49.47 µM 0.254688114450289 0.371795382218398 no 1223 0.399481998444832 1761 16013766
SGTC_3083 9117465 49.47 µM 0.251897537948745 0.372818158607946 no 1224 0.400560131336592 1784 16420915
SGTC_2693 st077581 40.7 µM 0.24802657802007 0.374238391469786 no 1225 0.402056921442977 1980 25238761
SGTC_1866 st057638 64 µM 0.247315375409335 0.374499513950716 no 1226 0.402332080232023 1849 688802
SGTC_2507 purpurin 79.67 µM 0.247294961680662 0.374507009829181 no 1227 0.402339978860961 1768 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_293 4049-0273 38.5 µM 0.244979204668778 0.3753576581812 no 1228 0.403236266548309 1915 1380311
SGTC_385 1494-0393 12.4 µM 0.244647641705134 0.375479501119591 no 1229 0.403364635991759 1909 3090647
SGTC_367 0335-0881 7.1 µM 0.244277706117006 0.375615459911662 no 1230 0.403507874247275 1934 23828853
SGTC_581 0958-0271 211 µM 0.243949312911786 0.375736163983277 no 1231 0.403635038228789 1831 4591145
SGTC_853 0419-0306 21 µM 0.243621098339456 0.375856814548688 no 1232 0.403762143217507 1837 762713
SGTC_612 0302-0167 22.4 µM 0.242656509757423 0.376211464257446 no 1233 0.404135750374076 1957 235821
SGTC_2275 7947463 200 µM 0.24253699392504 0.376255413857956 no 1234 0.404182047677842 1997 1225414
SGTC_2918 7977171 22.06 µM 0.241302700147098 0.37670939491867 no 1235 0.404660259150757 1870 2236483
SGTC_2282 7944268 200 µM 0.240073038931041 0.377161841693735 no 1236 0.405136817447143 1937 2970414
SGTC_2489 cantharidin 73.42 µM 0.238423430608576 0.377769070449025 no 1237 0.405776348168408 1803 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1216 1165-0504 9.65 µM 0.237957184052473 0.377940752887667 no 1238 0.405957151293309 2006 6304004
SGTC_775 4577-0580 57.3 µM 0.236117872818402 0.378618263396899 no 1239 0.406670602743505 1949 2006902
SGTC_2308 7584454 197.62 µM 0.23611675515735 0.378618675201155 no 1240 0.406671036368116 1982 893577
SGTC_1421 4029-0249 71.4 µM 0.235309858041429 0.378916013857999 no 1241 0.406984122154314 2018 2894095
SGTC_1952 st077036 64.1 µM 0.234558827779111 0.379192830186724 no 1242 0.407275584353017 2019 2937007
SGTC_182 3448-4371 550.524 µM 0.230384754095354 0.380732444559016 no 1243 0.408896403511477 2084 3491403
SGTC_664 1222-0054 14.9 µM 0.230234413923606 0.38078793321296 no 1244 0.408954810803872 1889 6813991
SGTC_1547 harmine 94.2 µM 0.229363292714584 0.381109501256566 no 1245 0.409293281936445 1907 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1499 4480-0877 67.3 µM 0.228959471434009 0.381258596808422 no 1246 0.409450208256489 1992 2861909
SGTC_1312 1218-2183 165 µM 0.22723637972557 0.381894980283543 no 1247 0.410119970292276 1999 6744073
SGTC_1481 3346-2004 36 µM 0.227049967319676 0.381963846499384 no 1248 0.410192444149734 1994 2770522
SGTC_2016 5121758 140 µM 0.226315570162904 0.382235190695212 no 1249 0.410477994643549 1966 2795203
SGTC_52 0329-0193 875 nM 0.22583561051754 0.382412556883537 no 1250 0.410664639640325 1986 3739292
SGTC_1173 0443-0020 122 µM 0.223367452111628 0.383325038821176 no 1251 0.411624766929655 1874 5331295
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.223180182221224 0.383394299282265 no 1252 0.411697637634716 1955 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_928 2764-0428 58.7 µM 0.223096714223459 0.383425170539106 no 1253 0.411730117792757 1932 662578
SGTC_154 3389-1638 511.116 µM 0.221820485520703 0.383897285239205 no 1254 0.412226815780047 1772 5238686
SGTC_3218 9131285 49.47 µM 0.220866286766647 0.384250384205137 no 1255 0.412598274213973 2012 17156417
SGTC_2072 5231554 129 µM 0.220656593863435 0.3843279934498 no 1256 0.412679915717396 2083 789545
SGTC_383 2324-0395 7.37 µM 0.219410391658548 0.384789319759216 no 1257 0.413165187934396 1963 3146421
SGTC_2143 5623677 140.463 µM 0.218369095035246 0.385174918101203 no 1258 0.413570771540534 2009 5375313
SGTC_2322 7413319 38.22 µM 0.218085928517908 0.385279796004918 no 1259 0.413681080479498 1922 1840400
SGTC_2241 6772625 37.8075 µM 0.217663476630092 0.38543627737432 no 1260 0.413845661394211 2057 2285411
SGTC_442 cape 100 µM 0.216635490254872 0.385817134025784 no 1261 0.414246212622038 2034 5281787
SGTC_555 4296-0685 37 µM 0.215963627206691 0.38606611076116 no 1262 0.414508049896697 1951 2908540 YHR072W ERG7
SGTC_2534 helenine 20.12 µM 0.215764887248905 0.386139768141513 no 1263 0.414585509767166 1894 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_454 lyso-paf C-16 6.67 µM 0.213685813521078 0.386910563961965 no 1264 0.415396037499804 1836 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_42 0133-0086 60.653 µM 0.213374240237013 0.387026115167156 no 1265 0.415517535584538 1906 162923 Model of phenazepam hydroxylation.
SGTC_332 4112-0506 40.9 µM 0.213156902946046 0.387106723597039 no 1266 0.415602291101917 1930 2790355
SGTC_3038 9091290 49.47 µM 0.211912115872161 0.387568497533926 no 1267 0.416087799077706 2005 25236843
SGTC_800 3448-7362 155 µM 0.210778854061826 0.387989037740215 no 1268 0.416529919931723 2057 15991913
SGTC_213 1246-0773 967 nM 0.209375448728078 0.388510007119217 no 1269 0.417077578546443 1977 6251622
SGTC_2902 5787006 60.46 µM 0.208092293642879 0.388986513039712 no 1270 0.417578452119979 1902 591003
SGTC_3283 9109332 35.8195 µM 0.207875875195172 0.389066897570798 no 1271 0.417662943250682 1961 17027281
SGTC_1133 3473-0247 50 µM 0.206622461302546 0.389532547697619 no 1272 0.418152358601419 1813 711311
SGTC_3299 9121982 43.1275 µM 0.206369135579817 0.389626678884114 no 1273 0.418251289074287 1911 17594604 YPL160W CDC60
SGTC_2088 5278280 127.392 µM 0.205970243505682 0.389774912977123 no 1274 0.418407077583834 1957 791502
SGTC_3332 9141069 11.198 µM 0.205114616849574 0.390092930338777 no 1275 0.418741288314404 1871 17332883
SGTC_1257 0669-0121 16 µM 0.204122481086257 0.390461777198732 no 1276 0.419128893402964 2028 4307855
SGTC_1288 0973-0013 65.5 µM 0.203429156766822 0.390719593315339 no 1277 0.419399806213978 1967 4315430
SGTC_2624 nerol 100 µM 0.2029616333824 0.390893471355456 no 1278 0.419582510083243 1994 637566 A natural product oil.
SGTC_3269 9137823 49.47 µM 0.202803726281267 0.390952203994467 no 1279 0.419644222655072 1892 17682936
SGTC_842 0271-0008 11.1 µM 0.20141920881625 0.391467273683489 no 1280 0.420185398262893 1997 1221709
SGTC_352 k048-0007 5.11 µM 0.200817548121971 0.391691163534553 no 1281 0.420420620511716 2044 6811911
SGTC_1884 5633444 25 µM 0.200636059400871 0.391758706126155 no 1282 0.420491580015826 1978 5724239
SGTC_1791 st048313 56.1 µM 0.200633878046898 0.391759517955681 no 1283 0.420492432909869 2071 1204976
SGTC_2745 rifampicin 24.3 µM 0.200595253772059 0.3917738927419 no 1284 0.420507534791168 2072 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2844 9010103 25.97 µM 0.196738539530596 0.393209985941351 no 1285 0.422016074634433 1928 2480525
SGTC_1741 st038134 10.228 µM 0.196387817061963 0.393340654037937 no 1286 0.422153315584879 2017 1272587
SGTC_2587 piperic acid 92.2 µM 0.195788946344683 0.39356380208881 no 1287 0.422387681086528 1913 5370536
SGTC_870 0573-2213 57.6 µM 0.195379738096006 0.393716299221614 no 1288 0.422547838799298 2047 3916321
SGTC_281 1672-3440 14.9 µM 0.194826477672735 0.393922505312552 no 1289 0.422764396637324 2053 6833000
SGTC_2167 5876490 200 µM 0.193322229300343 0.394483305025561 no 1290 0.423353309116758 2065 686534
SGTC_1352 1496-0991 99 µM 0.193061154812002 0.394580658669206 no 1291 0.42345553712686 1932 3000039
SGTC_1959 st077091 55.8 µM 0.192904612869033 0.394639035698309 no 1292 0.42351683617098 1958 821356 YKL052C ASK1
SGTC_449 xestospongin c 11.1929 µM 0.191447649041676 0.395182474457046 no 1293 0.424087445922202 2022 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_622 1348-1566 26.3 µM 0.191149864819455 0.395293571318364 no 1294 0.42420409067252 2011 7340407
SGTC_2015 5119600 184 µM 0.190549931181786 0.395517419437416 no 1295 0.424439110211616 2051 2828786
SGTC_549 1661-1316 519 µM 0.190496322364615 0.3955374237169 no 1296 0.42446011237582 2089 2857282
SGTC_2486 5283202 22.39 µM 0.190370939329126 0.395584211820455 no 1297 0.424509234145858 1898 1377751
SGTC_2954 9074818 52.69 µM 0.18981119407715 0.395793105464056 no 1298 0.424728541879611 1998 16648742
SGTC_2472 5377652 49.4 µM 0.189683541671676 0.395840748786692 no 1299 0.424778559253464 1936 1610903
SGTC_818 4072-2707 53.5 µM 0.189207553618469 0.396018414088151 no 1300 0.424965073832078 1984 882871
SGTC_1534 6-azauridine 81.6 µM 0.187671919178852 0.396591745640134 no 1301 0.425566922177243 1987 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2263 7948595 193.29 µM 0.187472205408626 0.396666325553519 no 1302 0.425645207099331 1922 2971371
SGTC_1620 st003704 16.5 µM 0.18573044909929 0.397316916560927 no 1303 0.426328074414794 2081 2834414
SGTC_3064 1327-0027 10 µM 0.185608687388455 0.39736240841618 no 1304 0.426375820201037 1996 16000455 YPR107C YTH1
SGTC_188 3229-0966 278.469 µM 0.18510108123899 0.397552072113569 no 1305 0.426574876777949 2085 5722370
SGTC_46 0329-0187a 2.197 µM 0.184427057351242 0.397803954131993 no 1306 0.426839222584658 2008 46494817
SGTC_256 clotrimazole 625 nM 0.184250033218533 0.397870114933103 no 1307 0.426908655232172 2074 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3065 9113888 49.47 µM 0.183775513806264 0.398047475770732 no 1308 0.427094783050969 2031 16648368
SGTC_2607 solasodine 47.35 µM 0.182834963859534 0.398399086799186 no 1309 0.427463756902985 1952 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2116 5511452 16.8835 µM 0.181526070976242 0.398888534759526 no 1310 0.427977335695111 2019 870744
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.17830551663585 0.400093505801513 no 1311 0.429241523294979 2073 368090
SGTC_1001 4048-4355 44.4 µM 0.177506632552776 0.400392556217049 no 1312 0.429555227968484 1984 21824233
SGTC_3025 9087895 49.47 µM 0.17274279157483 0.402177036284401 no 1313 0.431426803279995 2101 17173641
SGTC_2572 astragaloside iv 100 µM 0.172230653108793 0.402368999615326 no 1314 0.431628100123396 1972 45006101 An anti-inflammatory agent.
SGTC_2708 st078559 56 µM 0.171427520782006 0.402670082705455 no 1315 0.431943808305966 2098 17250902
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.170769661317198 0.402916748052215 no 1316 0.432202442688661 1970 688667
SGTC_3142 9086498 49.47 µM 0.169692982661847 0.403320533589322 no 1317 0.432625796528801 2127 25236367
SGTC_2447 5741742 33.78 µM 0.168927396352299 0.403607713270872 no 1318 0.432926874849008 2051 1776504
SGTC_3317 9138495 8.753 µM 0.16715850901876 0.404271440531764 no 1319 0.433622665012688 2138 17020139
SGTC_2944 9067346 25.62 µM 0.166374749361968 0.404565613438631 no 1320 0.433931022042933 2026 6473075
SGTC_151 3013-0144 2.285 µM 0.165523748154243 0.404885085587755 no 1321 0.434265879656929 2117 906558 YHR107C CDC12
SGTC_845 0330-0138 4.51 µM 0.163311500411458 0.405715875912113 no 1322 0.435136589722967 2118 9039800
SGTC_1164 k060-0068 93.7 µM 0.16278948909354 0.405911974798302 no 1323 0.435342092180632 2136 5963676
SGTC_2481 5478948 45.16 µM 0.162575210545773 0.405992477562417 no 1324 0.435426453203889 1996 77792
SGTC_2698 st077697 67.5 µM 0.162031918920857 0.406196605759329 no 1325 0.435640359161814 1964 3154499
SGTC_3171 9103192 49.47 µM 0.161392320362037 0.406436951548272 no 1326 0.435892207424279 2157 13018434
SGTC_537 1334-0398 209 µM 0.161144837287499 0.406529959213283 no 1327 0.435989663315803 2140 5846986
SGTC_1150 3909-7983 10.9 µM 0.158529745303407 0.407513069316254 no 1328 0.437019691826085 1996 23965914
SGTC_2999 9069765 71.4286 µM 0.158058982420731 0.407690108628796 no 1329 0.437205160767892 2068 2097066
SGTC_2105 5350118 200 µM 0.157878222629209 0.407758091788709 no 1330 0.437276379327776 2001 2133313
SGTC_33 0986-0033 35.816 µM 0.155951129677175 0.408483037338475 no 1331 0.438035771326917 2130 2848082
SGTC_2900 5328528 85.29 µM 0.154402704190851 0.40906576058386 no 1332 0.438646110796492 2082 795359
SGTC_3020 9089140 49.47 µM 0.152897506651226 0.409632408445073 no 1333 0.439239551097703 2015 17217859
SGTC_2567 aureobasidin a 60 nM 0.152634369322982 0.409731488755747 no 1334 0.439343309880044 2030 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3133 9127736 49.47 µM 0.152263487324338 0.409871148450988 no 1335 0.43948956098954 2172 27243420
SGTC_3244 9134489 49.47 µM 0.15179206701139 0.410048683456976 no 1336 0.43967546961936 2001 16584271
SGTC_2930 9013230 14.89 µM 0.151561328506972 0.410135585379424 no 1337 0.439766468172617 2107 2995857
SGTC_934 2950-0684 338 µM 0.151463117407681 0.410172575488135 no 1338 0.439805201590008 2153 1121253
SGTC_505 gw-5074 63.9 µM 0.14925387562165 0.41100487222946 no 1339 0.440676654719151 2109 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2153 5569715 200 µM 0.148854637705065 0.411155321638379 no 1340 0.440834168097403 2138 2054701
SGTC_2386 9075165 157.42 µM 0.148788988071609 0.41118006239538 no 1341 0.440860070080107 2057 16452277
SGTC_2309 7664088 163.95 µM 0.148631948325449 0.41123924591362 no 1342 0.440922030946446 2179 704922
SGTC_3313 9133968 57.047 µM 0.148472307615058 0.411299411726993 no 1343 0.440985019519417 2098 1494643
SGTC_2920 7982904 15.77 µM 0.146703805141744 0.41196606888113 no 1344 0.441682907517931 2039 6456808
SGTC_2629 bisabolol 100 µM 0.146468954438084 0.412054617687167 no 1345 0.441775598175844 2080 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_640 3381-0960 37.1 µM 0.144049781700887 0.412967009599358 no 1346 0.442730579708404 2137 1745025
SGTC_3240 9133527 49.47 µM 0.143233230850295 0.413275078476777 no 1347 0.443052992984144 2044 17617455
SGTC_563 tetrahydrosecaminediol 614 µM 0.142256871491103 0.413643510111067 no 1348 0.443438555777417 2150 334274 A psychoactive constituent of the cannabis plant.
SGTC_1962 st076595 64.5 µM 0.141470984744954 0.413940121682216 no 1349 0.443748940152087 2093 279619
SGTC_1737 st035557 69.7 µM 0.141365969146657 0.413979760685381 no 1350 0.443790418467391 2159 5716916
SGTC_2255 7941087 197.44 µM 0.14118516579993 0.414048008451977 no 1351 0.443861832331873 2169 935561
SGTC_714 4296-0578 26.1 µM 0.140377565887068 0.414352884530829 no 1352 0.444180841078791 2145 1589775
SGTC_2663 amphotericin b 100 µM 0.140068218693688 0.414469679501514 no 1353 0.444303045409109 2066 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1337 1486-1011 40.3 µM 0.139368882733695 0.414733743771902 no 1354 0.444579330167277 2177 X1337
SGTC_285 1486-1325 46 µM 0.138483919728959 0.415067954711601 no 1355 0.444928988681267 2148 22310230
SGTC_2135 5326629 150.42 µM 0.137700302294562 0.415363943286997 no 1356 0.445238640239949 2031 5020077
SGTC_1381 2324-0066 62.1 µM 0.137455214403678 0.415456527941535 no 1357 0.445335495192908 2070 10885928
SGTC_2553 4-methylesculetin 85.09 µM 0.136512222115308 0.415812797412774 no 1358 0.445708181574422 2010 5319502
SGTC_940 3232-1287 54.8 µM 0.136132990783571 0.415956093347129 no 1359 0.445858073708198 2203 1585493 YIL048W NEO1
SGTC_2053 5265679 138 µM 0.135436882546122 0.416219153108263 no 1360 0.446133232356513 2103 764595
SGTC_396 dithiazanine 1.25 µM 0.134961321319783 0.416398889596804 no 1361 0.446321227794155 2006 10578 An antihelmenthic.
SGTC_1363 1636-0063 10.4 µM 0.133033014644934 0.417127864275064 no 1362 0.447083635317579 2090 6072185
SGTC_594 1487-1584 10.8 µM 0.132729257571147 0.417242722270812 no 1363 0.447203751690528 2042 5013332
SGTC_1625 st003711 30.1 µM 0.131983059219742 0.417524908125183 no 1364 0.447498845652012 2136 24207034 YER133W GLC7
SGTC_2716 st080858 38.6235 µM 0.131604011190659 0.417668266977382 no 1365 0.447648756326878 2173 5296050
SGTC_2149 5554786 194.827 µM 0.131302243627111 0.417782405593412 no 1366 0.44776810850048 2051 745063 YPR165W RHO1
SGTC_1267 0828-0272 9.49 µM 0.131207847082321 0.417818110956033 no 1367 0.447805444275905 2158 745334
SGTC_2025 5147754 141 µM 0.131013433188082 0.417891649876992 no 1368 0.447882340427207 2165 315777 YLR208W SEC13
SGTC_2139 5578692 56.4705 µM 0.129976067538263 0.418284091859185 no 1369 0.448292680693113 2197 650991 YMR113W FOL3
SGTC_1698 5-fluorocytosine 1.055 µM 0.129972230301792 0.418285543661272 no 1370 0.448294198653018 2174 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_799 1310-0557 151 µM 0.129485038062949 0.418469879808497 no 1371 0.448486931589907 2069 5354492
SGTC_341 1486-1430 230 µM 0.128432650171049 0.418868126874973 no 1372 0.448903297003832 2130 2054753 YPL210C SRP72
SGTC_2841 9004761 38.96 µM 0.126240750164042 0.419697857267125 no 1373 0.449770677704949 1964 2991039
SGTC_3153 9100258 49.47 µM 0.125809260415323 0.419861237269564 no 1374 0.449941455635557 2035 25236848
SGTC_1431 4049-0260 9.09 µM 0.125595393013338 0.41994222150315 no 1375 0.450026104960472 2122 3854841
SGTC_2560 caryophyllene 100 µM 0.12526740720668 0.420066425038829 no 1376 0.450155927090027 2218 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.125074405171591 0.420139515871615 no 1377 0.450232322935858 2041 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_315 k915-0449 187 µM 0.123766351110143 0.420634954930413 no 1378 0.450750137422337 2102 20970215 YNL149C PGA2
SGTC_125 0133-0007 11.75 µM 0.122628248121298 0.421066125585745 no 1379 0.451200742247741 2207 26541
SGTC_1934 st074720 32.6 µM 0.121733810434712 0.421405050046556 no 1380 0.45155491775365 2168 17250992
SGTC_134 0269-0018 6.916 µM 0.121402485322797 0.421530612084848 no 1381 0.451686124219744 2065 4378915
SGTC_284 0988-0104 32.6 µM 0.12022122954098 0.421978336585116 no 1382 0.452153950499784 2176 4666532
SGTC_556 4058-0063 51.5 µM 0.120151828315825 0.422004644469833 no 1383 0.452181438335978 2092 6615692
SGTC_481 bay k-8644 50 µM 0.119697159255844 0.422177004227105 no 1384 0.452361525383225 2061 2303 A calcium channel antagonist.
SGTC_729 4092-0585 94.1 µM 0.118639905742372 0.422577854322128 no 1385 0.452780324198811 2080 2169061
SGTC_1794 st048918 76.9 µM 0.117939173547745 0.422843576127187 no 1386 0.453057926916831 2201 672303
SGTC_1000 4048-0884 8.67 µM 0.117560825701895 0.422987062478291 no 1387 0.453207823098056 2111 13040088
SGTC_1508 1080-0625 72.9 µM 0.113766864748563 0.424426463229672 no 1388 0.454711303054792 2206 767111
SGTC_903 1134-0042 114 µM 0.113160664232469 0.424656545166391 no 1389 0.454951590346141 2068 701009
SGTC_2856 9022925 19.48 µM 0.112779910753686 0.424801072358235 no 1390 0.455102522805282 2130 4944862
SGTC_2157 5649910 96.377 µM 0.111510469648113 0.425283002367421 no 1391 0.455605781900286 2102 2858091
SGTC_2541 muurolladie-3-one 83.07 µM 0.111248555088217 0.425382449404718 no 1392 0.455709624585253 2169 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3270 9137563 49.47 µM 0.107854617025729 0.426671529915467 no 1393 0.457055508704897 2191 17015724
SGTC_1509 1326-1131 80 µM 0.107260264901474 0.426897356878222 no 1394 0.457291253323889 2213 768313
SGTC_1127 asiatic acid 681.4 nM 0.106501990481944 0.427185501687372 no 1395 0.457592038108148 2065 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_200 k038-0079 37.545 µM 0.103304972831427 0.428400796091074 no 1396 0.458860464494594 2173 3436683
SGTC_2667 digitoxin 100 µM 0.102777474694458 0.428601381549621 no 1397 0.459069791582385 2243 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2829 7992743 58.44 µM 0.102355623924126 0.428761807013496 no 1398 0.459237202795141 2257 16462845
SGTC_2030 5175110 200 µM 0.101280915629311 0.429170560539216 no 1399 0.459663732703345 2168 2831986
SGTC_2765 myclobutanil 7.74 µM 0.0985832942292019 0.43019690498639 no 1400 0.460734567336744 2127 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3259 9138485 49.47 µM 0.0972877300801468 0.430689987016769 no 1401 0.461248949877246 2230 17646153
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0972647220280696 0.430698744688343 no 1402 0.461258085436233 2231 165521
SGTC_421 streptovitacin 30 mM 0.0970216179257149 0.430791280717704 no 1403 0.461354613407397 2117 91467 include heat shock
SGTC_1830 st055982 50.3 µM 0.0966357887031336 0.430938151954955 no 1404 0.461507817106834 2252 455313 An antimicrobial agent.
SGTC_1793 st048256 72.231 µM 0.0952161725705291 0.43147863057135 no 1405 0.46207156224778 2249 672022
SGTC_1071 trifluoperazine 6.31 µM 0.0947172696282172 0.431668604252532 no 1406 0.462269700234363 2196 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_669 0108-0021 26.2 µM 0.0939989227549661 0.431942166168594 no 1407 0.462555006232823 2286 17201
SGTC_771 0250-0039 27.3 µM 0.093360163361421 0.432185446881598 no 1408 0.462808718639688 2117 3005115
SGTC_2362 9071156 126 µM 0.0932879927084189 0.432212935732642 no 1409 0.46283738545721 2216 653133
SGTC_103 0844-0104 51.839 µM 0.0896287584679669 0.433607117141772 no 1410 0.46429111521107 2243 5375804
SGTC_2365 9042475 200 µM 0.0886137472028617 0.433993987252228 no 1411 0.464694441189878 2150 6464479
SGTC_1194 1488-0194 225 µM 0.0882650743436435 0.434126898030729 no 1412 0.464832998608353 2166 1391452
SGTC_2179 6298986 200 µM 0.0880515350449621 0.434208300858956 no 1413 0.46491785806239 2243 738374
SGTC_2978 9011784 42.97 µM 0.085956255405721 0.435007185086171 no 1414 0.465750595797812 2259 2994934
SGTC_2884 9058502 51.95 µM 0.0849726956438009 0.43538228660661 no 1415 0.466141548950618 2181 6471554
SGTC_1029 k015-0030 64.7 µM 0.0835324105052945 0.435931674935514 no 1416 0.466714103790166 2174 2208316
SGTC_1692 fluoroquinolonic acid 71 µM 0.0834461298329061 0.435964590128574 no 1417 0.466748405042063 2204 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1759 st043059 70 µM 0.0833494669610174 0.436001466551218 no 1418 0.466786834075279 2192 669426
SGTC_1305 1181-0477 144 µM 0.0832010203668889 0.436058099299058 no 1419 0.466845850709542 2248 6252086
SGTC_3213 9129884 49.47 µM 0.0831154431442216 0.436090747819876 no 1420 0.466879873240424 2162 17190742
SGTC_699 0375-0592 111 µM 0.0829398493010434 0.43615773989709 no 1421 0.466949684009977 2287 762578
SGTC_525 k781-2675 26.7 µM 0.0826380606404184 0.436272881749849 no 1422 0.467069668373539 2279 3651118 YDL195W SEC31
SGTC_2243 6634756 200 µM 0.0822146769911897 0.436434425010583 no 1423 0.46723800120285 2252 885676
SGTC_1611 st001856 99.4 µM 0.0809863455634723 0.436903158341228 no 1424 0.467726405747414 2122 647478
SGTC_2228 7354201 200 µM 0.0808473449089691 0.436956206816124 no 1425 0.46778167774126 2200 753451
SGTC_1057 3448-5381 134 µM 0.0801022619275587 0.437240581007109 no 1426 0.468077961886334 2246 5497911
SGTC_298 1391-0729 10 µM 0.0797597693465817 0.437371310288539 no 1427 0.468214160875826 2232 3237558
SGTC_14 0354-0009 295 µM 0.079447342688335 0.437490569383339 no 1428 0.468338406798348 2251 1713507
SGTC_2497 7-hydroxyflavone 100 µM 0.0788448690810422 0.437720560845707 no 1429 0.468578007371368 2260 5281894
SGTC_58 0957-0393 9 µM 0.0768112703199479 0.438497032536249 no 1430 0.469386842405153 2245 6997992
SGTC_1280 0880-0253 10.1 µM 0.0756872281316972 0.438926317797164 no 1431 0.46983396866008 2205 6836607
SGTC_679 0422-0091 41.4 µM 0.0753766129384778 0.439044958175753 no 1432 0.469957533217609 2247 627384 YHR062C RPP1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0738919730715852 0.439612096159313 no 1433 0.470548171475116 2125 688788
SGTC_1942 st076330 65.2 µM 0.0732296615770919 0.439865141681351 no 1434 0.470811681610699 2225 24208414
SGTC_308 4092-1169 104 µM 0.0726499868046392 0.440086634833726 no 1435 0.471042324032358 2233 2268590 YDL196W YDL196W
SGTC_2264 7948757 110.76 µM 0.0721674890435011 0.440271011049705 no 1436 0.471234308836754 2277 2971411
SGTC_1182 1222-0449 220 µM 0.0717869936784579 0.440416418364528 no 1437 0.471385711827562 2225 658318
SGTC_1308 1187-1617 41.4 µM 0.0707664689622591 0.440806454220845 no 1438 0.471791809392743 2262 2882570
SGTC_2137 5261020 140 µM 0.0697054425205966 0.441212030381638 no 1439 0.472214054908239 2286 763655
SGTC_1333 1482-0047 286 µM 0.0691279790260214 0.441432791089685 no 1440 0.472443875125836 2300 3811116
SGTC_232 clozapine 119 µM 0.0683083198592544 0.441746172928355 no 1441 0.472770100655339 2288 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1973 st070275 50.2 µM 0.0677988046333253 0.441940995240772 no 1442 0.472972897669521 2283 17118334
SGTC_1754 st042065 16.137 µM 0.0673505328007131 0.442112411656002 no 1443 0.473151324411547 2220 1126236 YIL048W NEO1
SGTC_1101 ebselen 5.29 µM 0.0667959827004583 0.442324483229063 no 1444 0.473372060804592 2297 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1632 st005650 90 µM 0.0665381287735193 0.442423097604804 no 1445 0.473474701291671 2217 2759605
SGTC_2512 diallyl trisulfide 49.23 µM 0.0659341577390527 0.44265409592833 no 1446 0.473715122898897 2296 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1748 st037455 53.6035 µM 0.065572478165408 0.442792435369298 no 1447 0.473859100591648 2250 580690
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0642903607160899 0.443282890746923 no 1448 0.474369514305955 2264 5282309
SGTC_334 1502-1024 68.5 µM 0.0623964189440854 0.444007549414183 no 1449 0.475123573336879 2211 3296216
SGTC_1629 st005085 44.9 µM 0.062339480887974 0.444029337924424 no 1450 0.475146244199797 2240 24207091
SGTC_791 1348-1292 225 µM 0.0622028066627161 0.444081639798859 no 1451 0.475200663713353 2261 5437054
SGTC_163 TUB2.036 7.546 µM 0.0598517314552982 0.444981490331984 no 1452 0.476136861824347 2314 15992207 YJR013W GPI14
SGTC_3319 9138450 16.7555 µM 0.0593702799758566 0.445165796206714 no 1453 0.476328592216513 2177 2029690
SGTC_1104 tacrolimus 29.8 µM 0.0592461184536894 0.445213328772973 no 1454 0.476378038458106 2298 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1721 st082152 9.2685 µM 0.0569541496180939 0.446090900472512 no 1455 0.477290859560484 2311 5296051
SGTC_686 1319-0111 510 µM 0.0568676100229091 0.446124040810652 no 1456 0.477325327999678 2286 4562600
SGTC_3052 9092717 49.47 µM 0.0556496843765821 0.446590485254236 no 1457 0.47781044169567 2252 25237534
SGTC_2583 asiatic acid 100 µM 0.0554479319552155 0.446667760092442 no 1458 0.47789080518329 2275 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2575 plumbagin 510 nM 0.053960179287652 0.447237658698704 no 1459 0.4784834451593 2290 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1351 1496-0003 46.5 µM 0.0538970268500368 0.447261852293404 no 1460 0.478508602727355 2294 3891978
SGTC_1231 0242-0792 125 µM 0.0505021464157953 0.448562711914272 no 1461 0.479861119498358 2293 3707635
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0500756629441303 0.448726172427655 no 1462 0.480031046779071 2326 1241132 A phosphatase inhibitor.
SGTC_1825 st052143 62.6 µM 0.0495102766140101 0.448942884367624 no 1463 0.480256323845545 2308 674173
SGTC_1274 0865-0114 173 µM 0.0494926805270191 0.448949629172598 no 1464 0.480263335073207 2252 870624
SGTC_526 4469-0568 170 µM 0.0494160713612125 0.44897899461662 no 1465 0.480293860357291 2302 2901964
SGTC_497 capsazepine 133 µM 0.0493317992248101 0.449011297715197 no 1466 0.480327439121685 2304 2733484 A calcium channel blocker.
SGTC_672 1441-0018 53.7 µM 0.0491184470043074 0.449093081153951 no 1467 0.480412451283455 2309 251141
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0490267712743884 0.449128223503124 no 1468 0.4804489805982 2319 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_834 0312-0008 75.7 µM 0.048969373707729 0.4491502260981 no 1469 0.480471851443554 2326 6385573 YIL048W NEO1
SGTC_2603 homopterocarpin 100 µM 0.0489602684734999 0.449153716483101 no 1470 0.480475479554558 2276 101795 A weak amylase inhibitor.
SGTC_574 1315-0397 40 µM 0.0470434387114197 0.449888597932761 no 1471 0.481239303374072 2322 6794277
SGTC_3006 9075424 71.4286 µM 0.0464879488533833 0.450101595971346 no 1472 0.481460669562273 2277 7465181
SGTC_2759 disulfiram 3.38 µM 0.0463431906502674 0.450157104682822 no 1473 0.481518357554746 2302 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_653 0203-0016 55.2 µM 0.0436519693081558 0.451189251847029 no 1474 0.48259091281545 2290 295302
SGTC_1144 3486-0183 12.5 µM 0.0434022694847872 0.451285034488664 no 1475 0.482690434310258 2245 6744069
SGTC_684 1140-0066 328 µM 0.0411443283203115 0.45215128884623 no 1476 0.483590417807482 2270 6813534
SGTC_624 k048-0052 28 µM 0.0395590083307994 0.452759629898248 no 1477 0.484222354226169 2268 6835531
SGTC_2342 7990637 118.86 µM 0.0389254939421984 0.453002761950649 no 1478 0.484474895371016 2299 2033102 YER133W GLC7
SGTC_1243 0416-0003 5.65 µM 0.0384754452158213 0.453175493710865 no 1479 0.484654304431539 2292 2141977
SGTC_2430 5571206 200 µM 0.0371519664115838 0.453683505087519 no 1480 0.485181918698831 2343 1731771
SGTC_2941 9056145 11.23 µM 0.0371192507076473 0.453696063826458 no 1481 0.485194961379985 2348 2119517
SGTC_2366 9070441 60.58 µM 0.0365375138841867 0.453919385735788 no 1482 0.485426883456913 2341 6837235
SGTC_305 1682-2595 20.8 µM 0.034111648357207 0.45485080318201 no 1483 0.486394059922919 2296 226033
SGTC_3042 9091578 49.47 µM 0.0333240882956201 0.455153242572202 no 1484 0.486708072371452 2332 25236497
SGTC_3248 9135562 49.47 µM 0.0325752127839197 0.455440850407474 no 1485 0.487006668335097 2333 17650701
SGTC_1458 k015-0034 6.33 µM 0.0316610877735732 0.45579195443615 no 1486 0.487371163388022 2304 3598957
SGTC_1818 st052136 56.3 µM 0.03131649743873 0.455924316266608 no 1487 0.48750856690362 2304 674169
SGTC_3165 9101544 49.47 µM 0.0312861174996264 0.455935985848929 no 1488 0.487520680809918 2338 5002184
SGTC_346 4513-0042 7.16 µM 0.03061126478335 0.456195220947901 no 1489 0.487789779181416 2351 2827372
SGTC_2029 5175081 200 µM 0.0296541285089623 0.456562923224868 no 1490 0.488171447981769 2344 1380876
SGTC_2172 5754775 163.918 µM 0.0279923120008462 0.457201430121428 no 1491 0.48883414144014 2334 2263357
SGTC_418 lividomycin a 100 µM 0.0273136062424733 0.457462235855742 no 1492 0.489104802352802 2369 72394 An antibiotic.
SGTC_85 0868-0259 160.055 µM 0.0270962760808027 0.457545753025764 no 1493 0.489191472464336 2309 83173
SGTC_1634 st006576 41 µM 0.0268656378259235 0.457634386374297 no 1494 0.489283450330731 2353 3915356
SGTC_212 3807-4682 38.772 µM 0.0268016397892743 0.45765898093458 no 1495 0.489308972663151 2336 3125501 YBL034C STU1
SGTC_235 0330-0087 5 mM 0.0253142522070296 0.458230632129973 no 1496 0.489902152978575 2353 46494818 YHR062C RPP1
SGTC_2743 auranofin 4.32 µM 0.0252596579806463 0.458251616109575 no 1497 0.48992392596148 2346 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1832 st054113 55 µM 0.0249410966645126 0.458374061488404 no 1498 0.490050973510728 2365 1251267
SGTC_2082 5219693 150 µM 0.0237816019713903 0.458819769607325 no 1499 0.490513407699813 2363 2834649
SGTC_2069 5228469 200 µM 0.0228235777517604 0.459188071847474 no 1500 0.490895500297796 2340 2835210
SGTC_229 benomyl 22.8748 µM 0.0211148324097315 0.459845067612839 no 1501 0.491577026490495 2332 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2310 7668677 200 µM 0.0208757643183419 0.459936995726322 no 1502 0.491672379841501 2356 2197143
SGTC_2772 vinpocetine 57.06 µM 0.0202192980856806 0.460189435655895 no 1503 0.491934216692935 2362 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1834 st055981 52.8 µM 0.0201235587112251 0.460226252968891 no 1504 0.49197240340767 2366 471719 YDL150W RPC53
SGTC_368 fentichlor 4.58 µM 0.0188680616845963 0.46070909545003 no 1505 0.492473179043525 2330 7329 A pesticide.
SGTC_2152 5568786 200 µM 0.0185080840951418 0.46084754733445 no 1506 0.492616764247851 2377 5399883
SGTC_1248 0469-0687 58.6 µM 0.0161613856923456 0.461750232468501 no 1507 0.493552820595551 2357 4017482
SGTC_1365 1672-3266 55.4 µM 0.0155542903852597 0.461983791090492 no 1508 0.493794986127341 2375 6415873
SGTC_1201 1889-3372 45.9 µM 0.0152340918383958 0.462106981534383 no 1509 0.493922711730088 2335 5392199
SGTC_1662 st014054 52 µM 0.0149935134703841 0.462199541985561 no 1510 0.494018677651375 2371 2838777
SGTC_3126 9127922 49.47 µM 0.0146373641814368 0.462336571108315 no 1511 0.494160745067563 2351 45595682
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0145576253187845 0.462367251401858 no 1512 0.494192552882163 2380 2333 A French combination drug.
SGTC_979 1426-2828 121 µM 0.0143796135764075 0.46243574393767 no 1513 0.494263561859579 2360 747872
SGTC_302 1094-0063 18.9 µM 0.0139607339643891 0.462596918183949 no 1514 0.494430653869626 2371 5440289
SGTC_1669 st015249 58.4 µM 0.0135824858498007 0.46274246373818 no 1515 0.494581538725237 2380 722793
SGTC_829 1635-0120 117 µM 0.0131136222107212 0.462922884032869 no 1516 0.49476857159028 2380 285054
SGTC_322 k048-0136 19.3 µM 0.0108221370631348 0.46380476421883 no 1517 0.49568267623457 2353 6823282
SGTC_1398 3558-0053 112 µM 0.010756034706401 0.463830206432543 no 1518 0.495709045724693 2376 4532369
SGTC_1776 st049249 45.9 µM 0.010224728948663 0.46403470669328 no 1519 0.495920994390187 2377 1822314
SGTC_1590 st077108 57.8 µM 0.0101653224569096 0.464057572919009 no 1520 0.495944692919847 2383 5489485
SGTC_31 0508-1974 57.237 µM 0.00866846985048431 0.464633767277856 no 1521 0.496541824179565 2393 6810525
SGTC_3181 9108277 49.47 µM 0.00812791040543211 0.464841867048523 no 1522 0.496757468589851 2387 17097298
SGTC_527 4476-4215 268 µM 0.00747934155248899 0.465091560006936 no 1523 0.497016202244389 2344 4418754
SGTC_808 0711-0032 135 µM 0.00621403405392468 0.465578731068941 no 1524 0.497520975038314 2390 4252555
SGTC_348 k064-0012 10.7 µM 0.00534608239259761 0.465912941319294 no 1525 0.497867231858386 2398 5066323
SGTC_2679 rapamycin 1 nM 0.00409809425751464 0.466393529081753 no 1526 0.498365101507792 2397 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_19 0279-0214 38.434 µM 0.0028627793985052 0.466869284756858 no 1527 0.498857917818465 2398 3566274 YBR002C RER2
SGTC_1902 st060212 70.5 µM 0.0024385816533188 0.467032666597437 no 1528 0.499027147638487 2398 688944
SGTC_2059 5238311 157 µM 0.0021869451557851 0.467129588254417 no 1529 0.499127535807898 2397 703021
SGTC_1436 4092-1007 8.32 µM 0.00204661798840536 0.467183638262312 no 1530 0.499183518122587 2402 2881121
SGTC_2521 angolensin 13.4 µM 0.00176834959959624 0.46729082106874 no 1531 0.499294530945864 2402 821428 A flavenoid.
SGTC_3214 9129694 49.47 µM 0.00176476647521834 0.467292201224196 no 1532 0.499295960403444 2402 17158655
SGTC_2532 xanthone 78.9 µM 0.00160491122563219 0.467353775008497 no 1533 0.499359733330665 2402 7020 An insecticide.
SGTC_73 0327-0325 16.231 µM 0.000893717379999332 0.467627725391407 no 1534 0.499643458397852 2404 53298
SGTC_1349 flufenamic acid 69 µM 0.000299199160746402 0.467856744338569 no 1535 0.499880636806299 2404 3371 A non-steroidal anti-inflammatory.
SGTC_2398 5228213 48.84 µM 0 0.467972005183469 no 1536 0.5 2405 80771 YMR134W ERG29
SGTC_3013 9080133 71.4286 µM -0.000631786423554912 0.468215397820376 no 1537 0.499747953700228 2406 17050193
SGTC_1249 0481-0015 10.2 µM -0.00157916086941196 0.468580391441197 no 1538 0.499370006223477 2408 4227577
SGTC_2813 7971799 71.43 µM -0.00208934334056663 0.468776959685123 no 1539 0.499166473209613 2412 2234054
SGTC_611 3453-1652 23.7 µM -0.00215151269472246 0.468800913441644 no 1540 0.499141671281456 2406 1560575
SGTC_501 nsc-95397 161 µM -0.00239413086421445 0.468894394928726 no 1541 0.499044880885886 2413 262093
SGTC_2997 9067075 71.4286 µM -0.00250486197024937 0.468937060516534 no 1542 0.499000705698482 2414 27209819
SGTC_223 busulfan 5 mM -0.00313043731726182 0.469178106427101 no 1543 0.49875113823773 2412 2478 A DNA alkylator.
SGTC_1733 st037357 54.9 µM -0.00368468144171665 0.469391676521796 no 1544 0.498530028109361 2416 1272339 YGL099W LSG1
SGTC_607 4491-0986 66.8 µM -0.00381414105601329 0.469441563214938 no 1545 0.498478381558677 2413 698981 YDR232W HEM1
SGTC_1350 1495-0454 146 µM -0.00385085377931999 0.469455710388784 no 1546 0.498463735408684 2418 1069057
SGTC_2324 6149169 200 µM -0.00567928725852402 0.470160341958597 no 1547 0.497734304369775 2417 2888231
SGTC_2335 9018011 154.17 µM -0.00578772553350748 0.470202134257663 no 1548 0.497691044468141 2424 6458208
SGTC_1714 st033236 13.627 µM -0.00662501479904068 0.470524838008349 no 1549 0.497357020822146 2432 2916566
SGTC_1388 3346-4487 254 µM -0.00722172747304399 0.470754831784408 no 1550 0.497118972616025 2431 3345614
SGTC_3288 9119690 36.221 µM -0.0080222345402817 0.471063390301413 no 1551 0.496799625785967 2432 17595618 YKL019W RAM2
SGTC_3084 9116877 49.47 µM -0.00816978494030638 0.471120266070195 no 1552 0.496740763622064 2418 27241325
SGTC_765 1319-0117 244 µM -0.00851608672897223 0.471253756196503 no 1553 0.496602614005483 2423 3487746 YGL099W LSG1
SGTC_3331 9141060 1.957 µM -0.00874967279526144 0.471343799235517 no 1554 0.496509430120144 2420 4906567 YPR165W RHO1
SGTC_958 1222-0007 33 µM -0.00978986289242345 0.471744790692889 no 1555 0.496094472158198 2429 7312461
SGTC_1076 itraconazole 331 nM -0.0108625053930515 0.472158322488908 no 1556 0.495666572547547 2428 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_708 3448-5400 146 µM -0.0121537368592936 0.472656165832996 no 1557 0.495151479867416 2422 3462195
SGTC_185 k048-0037 25.491 µM -0.012268616449837 0.472700460545328 no 1558 0.495105652958435 2425 6827589
SGTC_2814 7977482 42.97 µM -0.0125461441227299 0.472807469703989 no 1559 0.494994943957863 2429 6456762
SGTC_226 1,3-diallylurea 8.28947 mM -0.0127045463429321 0.472868547334305 no 1560 0.494931755651269 2466 74537 YKL182W FAS1
SGTC_135 0933-0004 26.348 µM -0.0134180911348833 0.473143687887764 no 1561 0.494647116751293 2435 21230617 YGL099W LSG1
SGTC_2292 7671323 168.05 µM -0.0135647716392089 0.473200249005709 no 1562 0.494588605021817 2451 937504
SGTC_216 k038-0035 28.382 µM -0.0138295481100656 0.473302350193678 no 1563 0.494482984401368 2419 4444231 YPR107C YTH1
SGTC_1926 methyl fluorone black 53.6 µM -0.0140496596059607 0.473387229332389 no 1564 0.494395181150481 2428 72721 Reacts with homocysteine.
SGTC_1810 st050138 53 µM -0.0146412738372914 0.473615372900843 no 1565 0.494159185507664 2428 3444541
SGTC_1385 3091-4834 14.1 µM -0.015886049876486 0.4740954227353 no 1566 0.493662649592734 2449 4072814
SGTC_3017 9080681 49.47 µM -0.0166085637377 0.474374078639104 no 1567 0.493374446313325 2461 16451914
SGTC_768 0384-0033 77.3 µM -0.0192506331088958 0.475393165822164 no 1568 0.492320582846496 2450 3965305 YMR134W ERG29
SGTC_694 1315-0438 43.2 µM -0.0196231299365741 0.475536856735673 no 1569 0.492172006181694 2456 6793154
SGTC_3111 9122088 49.47 µM -0.0212158855898022 0.476151299008017 no 1570 0.491536721133268 2448 16876704
SGTC_2753 fluvastatin 17.09 µM -0.0219883394952301 0.476449311451196 no 1571 0.491228628512682 2467 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_74 000s-0487 160.283 µM -0.0220415558100156 0.476469842773514 no 1572 0.491207403418788 2443 677548
SGTC_1675 st018485 24.5 µM -0.0229184612847533 0.476808169573663 no 1573 0.490857657143646 2494 3323024
SGTC_3202 9113761 49.47 µM -0.0231594919797528 0.476901166736706 no 1574 0.490761525325272 2472 4798415
SGTC_1181 1222-0449 220 µM -0.0233844183159323 0.476987951470456 no 1575 0.490671816995566 2456 658318
SGTC_1442 4112-3290 3 µM -0.023866907497821 0.477174116962726 no 1576 0.490479385375401 2437 704353
SGTC_3107 9121808 49.47 µM -0.0248198008795677 0.477541799626685 no 1577 0.490099348552466 2460 662681
SGTC_2100 5377183 190 µM -0.0250374428292708 0.477625781465305 no 1578 0.490012548951309 2487 2844202
SGTC_2148 5546263 113.568 µM -0.0254236971552324 0.477774828468641 no 1579 0.489858504809294 2461 792097
SGTC_2752 diclazuril 33.15 µM -0.0256425693116065 0.477859287775182 no 1580 0.489771215910527 2466 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3080 9117754 49.47 µM -0.0257153701048996 0.477887380671494 no 1581 0.489742182170182 2444 9550191
SGTC_2047 4141938 200 µM -0.0269827039659694 0.478376446105124 no 1582 0.489236764622448 2468 3807862
SGTC_1357 1503-1303 39.5 µM -0.0295575302917333 0.479370173724243 no 1583 0.48820996820953 2458 292895
SGTC_2665 lovastatin 100 µM -0.029626566320479 0.47939681925919 no 1584 0.488182438875009 2481 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1404 3909-7820 48.3 µM -0.0299830084482463 0.479534395135114 no 1585 0.488040302186313 2464 23741373
SGTC_3220 9131269 49.47 µM -0.0304382023550749 0.479710089752423 no 1586 0.487858788943381 2457 17722206
SGTC_2254 7938975 95.19 µM -0.0308774285880805 0.479879624944068 no 1587 0.487683645357997 2484 2969277
SGTC_529 4076-0302 30.3 µM -0.0320582228410951 0.480335412994717 no 1588 0.487212809807417 2478 5816522
SGTC_1293 1000-1278 195 µM -0.0324591307322146 0.480490169815921 no 1589 0.487052953896622 2483 678847
SGTC_2199 6590217 200 µM -0.0350719281898998 0.481498822165384 no 1590 0.486011192847687 2482 703109
SGTC_473 2-arachidonoylglycerol 10 µM -0.0351334226690662 0.48152256313486 no 1591 0.485986675209884 2453 5282280 An endocannabinoid.
SGTC_323 4013-0906 34.3 µM -0.0353250079900941 0.481596528263617 no 1592 0.485910291139892 2521 2910086
SGTC_754 3474-0146 171 µM -0.035712054204813 0.481745956689158 no 1593 0.48575597940926 2465 24762078
SGTC_2696 st077691 74.316 µM -0.0375296555749622 0.482447719018494 no 1594 0.485031347533615 2526 757133
SGTC_1751 st044839 27.194 µM -0.0390467659274516 0.483033505741728 no 1595 0.484426551601954 2472 5291326
SGTC_3216 9129716 49.47 µM -0.0423861522105908 0.484323036995178 no 1596 0.483095433682071 2497 8056934
SGTC_2493 resveratrol 26.09 µM -0.042635261417899 0.484419239286994 no 1597 0.482996143244504 2468 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2989 9073649 71.4286 µM -0.0426501207383528 0.484424977765519 no 1598 0.482990220620612 2482 21367202
SGTC_2020 4017018 200 µM -0.0429114992671865 0.484525919319389 no 1599 0.482886041052804 2520 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2417 cerulenin 830 nM -0.0430674022320855 0.484586127826636 no 1600 0.482823902214239 2474 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1013 4112-3890 241 µM -0.0433411621565414 0.484691852620574 no 1601 0.482714789688836 2483 705171
SGTC_2826 7992541 19.48 µM -0.0434997628371973 0.484753103949557 no 1602 0.482651576788579 2472 2985066
SGTC_224 benfluorex 43.875 µM -0.0438674873718373 0.484895119957803 no 1603 0.48250501582987 2482 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3170 9103054 49.47 µM -0.0447200034116546 0.485224370830309 no 1604 0.482165244615348 2519 16432970
SGTC_2709 st078560 56 µM -0.0448403302656804 0.485270843173168 no 1605 0.482117289251517 2500 17250903
SGTC_1886 st057356 49.9 µM -0.0454049127172123 0.485488897485927 no 1606 0.481892282622931 2502 24207747
SGTC_330 1488-0319 80.1 µM -0.0457645004463189 0.485627780538853 no 1607 0.481748976844653 2538 6846614
SGTC_1327 1436-0082 2.18 µM -0.047256146574913 0.486203915310643 no 1608 0.481154539485919 2546 15992205
SGTC_1322 1348-1070 12 µM -0.0476018444104261 0.48633744211465 no 1609 0.481016781035424 2481 6758089
SGTC_404 fumagillin 50 µM -0.0476291753357082 0.486347998830323 no 1610 0.481005889927128 2508 12015870 A methionine aminopeptidase binder.
SGTC_3106 9121286 49.47 µM -0.0487225385852227 0.486770323985307 no 1611 0.480570207005329 2642 15943471
SGTC_2720 fluspirilene 36.88 µM -0.0493400608768275 0.487008856238357 no 1612 0.480324147208143 2546 3396 An atypical antipsychotic.
SGTC_1562 morin hydrate 59.1 µM -0.049722004356629 0.487156393064019 no 1613 0.48017196060226 2582 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2488 5268135 45.7 µM -0.0501546574481021 0.487323520080719 no 1614 0.479999572081166 2531 1270356 YLR208W SEC13
SGTC_1563 conessine 56.1 µM -0.0506861209069847 0.487528819016663 no 1615 0.479787818172607 2517 441082 An anti-amoebic, histamine inhibitor.
SGTC_3044 9093193 49.47 µM -0.0510106212713681 0.487654171839821 no 1616 0.479658528508789 2552 25236277
SGTC_2058 5236698 133 µM -0.0513959087747676 0.487803008005203 no 1617 0.479505022395668 2530 766665
SGTC_1762 st045503 25.4615 µM -0.0517272534782219 0.487931007481979 no 1618 0.479373010584441 2536 4645554
SGTC_1728 st035614 33.7865 µM -0.0522384604842537 0.488128490752665 no 1619 0.479169343859778 2627 15945546
SGTC_416 estradiol valerate 100 µM -0.0524187058278923 0.488198121637339 no 1620 0.479097534755527 2530 13791 A steroid.
SGTC_2219 9098279 200 µM -0.0524967882586799 0.488228285905524 no 1621 0.479066427203114 2503 902349
SGTC_428 3448-4153 16.5 µM -0.0551415516038774 0.489250031361614 no 1622 0.478012846544915 2480 3834874
SGTC_1022 4477-0945 21.3 µM -0.0552548356800378 0.489293797766654 no 1623 0.477967721534009 2513 4648966
SGTC_3277 9138724 49.47 µM -0.0558556480059784 0.489525918989606 no 1624 0.47772840169987 2535 15943418
SGTC_1515 3460-0031 42.1 µM -0.0562846463604742 0.489691662809164 no 1625 0.477557524937003 2530 2876596
SGTC_1082 camptothecin 424.86 nM -0.056683718894212 0.48984584636533 no 1626 0.477398571800799 2477 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2377 9073351 62.6 µM -0.0571431272844733 0.490023342841711 no 1627 0.477215590961738 2500 7337946 YHR072W ERG7
SGTC_2482 5981709 142.65 µM -0.0582527191899541 0.490452051523998 no 1628 0.47677366407027 2569 877755
SGTC_1729 st035615 45.989 µM -0.0583929319462961 0.490506225773215 no 1629 0.476717822328663 2641 17385451
SGTC_2350 9023895 38.85 µM -0.0589704364216602 0.490729359028069 no 1630 0.476487827718441 2573 2997209
SGTC_68 0986-0284 82.829 µM -0.0592571275390498 0.490840130372246 no 1631 0.476373654171324 2737 423278 YIL048W NEO1
SGTC_1356 1502-0781 85.8 µM -0.0593228118165425 0.490865509478446 no 1632 0.476347495953307 2499 567702
SGTC_439 amiodarone 34.4 µM -0.0598292600921865 0.491061192313398 no 1633 0.476145810564634 2610 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3072 9116419 49.47 µM -0.0598808195868498 0.491081114129856 no 1634 0.476125278115262 2548 17170162
SGTC_2775 cyproheptadine 69.59 µM -0.0609662710136447 0.491500521390156 no 1635 0.475693035449655 2513 2913 A selective serotonin reuptake inhibitor.
SGTC_2261 9010538 184.68 µM -0.0613960719226174 0.491666594660936 no 1636 0.475521890305906 2611 6457250
SGTC_2746 daunorubicin 9.88 µM -0.0619727529805426 0.491889424070225 no 1637 0.475292265126675 2487 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2908 7930301 100 µM -0.0622615692050294 0.492001023539076 no 1638 0.475177266202089 2513 2223178
SGTC_2460 5552655 174.22 µM -0.0624253664580845 0.492064315575368 no 1639 0.47511204741892 2623 5401989
SGTC_1297 1068-0111 14.1 µM -0.0635492450485305 0.492498592903376 no 1640 0.474664573290242 2498 767057
SGTC_502 l-744,832 89.3 µM -0.063762822401741 0.492581122235865 no 1641 0.474579540708576 2529 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_291 SEC14.278 35.5 µM -0.065123413065693 0.493106881162145 no 1642 0.474037869533952 2522 1068044
SGTC_3346 9158254 43.5805 µM -0.0653112093348081 0.493179450286029 no 1643 0.473963108821171 2580 17639500
SGTC_2044 5102272 200 µM -0.0659802691766937 0.493437993377397 no 1644 0.473696767067452 2585 592666
SGTC_2330 7979373 200 µM -0.0666937011870228 0.493713686127039 no 1645 0.473412774436663 2547 1863007
SGTC_2010 4012422 159 µM -0.0667459990461999 0.493733895797759 no 1646 0.473391956995888 2579 952393
SGTC_2345 9052315 157.45 µM -0.0671196740838524 0.493878297000786 no 1647 0.473243215779211 2580 6469265
SGTC_2323 6148992 148.28 µM -0.0671812702797264 0.493902100019067 no 1648 0.47321869779281 2575 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_734 2023-0417 80 µM -0.0672362945101234 0.493923363408382 no 1649 0.473196795822585 2592 3935732
SGTC_2801 7907800 81.82 µM -0.0679303680726801 0.49419158045991 no 1650 0.472920532177306 2581 6620925
SGTC_2612 dictamnine 15.46 µM -0.0684945238277155 0.494409594151848 no 1651 0.472695989596326 2604 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2817 7995342 71.43 µM -0.0694765006222619 0.49478907554447 no 1652 0.472305168616267 2529 18879975
SGTC_1705 st027868 56.3335 µM -0.0698071767272311 0.494916865211698 no 1653 0.472173567456604 2606 292948
SGTC_1490 4089-0339 670 nM -0.069960671921525 0.494976183554886 no 1654 0.472112481081778 2532 742542
SGTC_441 propafenone 146 µM -0.0712855654938754 0.495488194236537 no 1655 0.471585241534588 2524 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1672 st016598 6.51 µM -0.0721632372646661 0.495827378320839 no 1656 0.471236000640037 2608 4665860 YNL267W PIK1
SGTC_53 0973-0023 39.979 µM -0.0737809741972287 0.496452574911481 no 1657 0.470592333074277 2529 674768
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0738463009903326 0.49647782153859 no 1658 0.470566342355607 2667 61125 An anti-inflammatory.
SGTC_122 0236-0016 402.397 µM -0.0748681000674241 0.49687271458007 no 1659 0.470159828879263 2545 6808838
SGTC_1225 1216-0074 20.6 µM -0.0753892556242621 0.497074125932008 no 1660 0.469952503826009 2570 4241466
SGTC_2683 piperine 63.03 µM -0.0764165267649128 0.497471138262237 no 1661 0.469543860796672 2546 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_282 k297-0036 65.7 µM -0.0764712011160859 0.497492268484228 no 1662 0.469522112524065 2620 5061378
SGTC_638 3970-0837 4.09 µM -0.0765615603165179 0.497527189992479 no 1663 0.469486169790734 2568 4118451 YLR208W SEC13
SGTC_214 4373-3496 70 µM -0.0767693570838893 0.49760749817303 no 1664 0.469403514140045 2567 3779166
SGTC_1827 berberine 7.24 µM -0.0774381809537529 0.497865982278246 no 1665 0.469137483975103 2550 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_245 methotrexate 289.6 µM -0.077709676637713 0.497970908996899 no 1666 0.46902949827102 2593 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2656 pseudo-anisatin 100 µM -0.0779458091475087 0.498062168791953 no 1667 0.468935579899648 2541 6708809 A neurotoxin.
SGTC_314 1671-0008 2.74 µM -0.0782170460954865 0.498166995771455 no 1668 0.468827701367189 2539 3913060
SGTC_3320 9137005 35.139 µM -0.0791269336733773 0.498518647737238 no 1669 0.468465830349859 2601 4908713
SGTC_2373 9071805 200 µM -0.0802075419792559 0.49893628106303 no 1670 0.468036095929074 2552 10149009
SGTC_2478 5763493 32.33 µM -0.0811061671415477 0.499283582479855 no 1671 0.467678760589589 2572 1365576 YLR208W SEC13
SGTC_209 4077-0173 175.592 µM -0.0814055642698344 0.49939929387015 no 1672 0.467559712076195 2627 15993494
SGTC_484 loperamide 105 µM -0.081509667776532 0.49943952794072 no 1673 0.467518318344723 2527 3955 An opioid-receptor agonist.
SGTC_781 4335-2806 94.4 µM -0.0821073676840462 0.4996705279445 no 1674 0.467280667172332 2712 845254
SGTC_72 0744-0168 198.391 µM -0.0821409195074869 0.499683495110185 no 1675 0.467267326992898 2597 677577
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0825567353832158 0.499844200359208 no 1676 0.467102001973514 2547 688664
SGTC_2178 5812956 200 µM -0.0826330168569203 0.499873681760483 no 1677 0.467071673693532 2522 5403383
SGTC_864 0469-0573 172 µM -0.0829442217086879 0.499993956777245 no 1678 0.466947945661378 2549 689425
SGTC_2348 9022543 33.42 µM -0.0829754947071788 0.499993956777245 no 1679 0.466935512398704 2636 3162678 YDL140C RPO21
SGTC_3279 9140807 49.47 µM -0.0835207537372 0.499783224083221 no 1680 0.466718737973952 2541 45595718
SGTC_2031 5180455 200 µM -0.0843951539975215 0.499445284443439 no 1681 0.46637113004603 2559 29949
SGTC_2363 9053361 176 µM -0.0847806172241539 0.499296310098524 no 1682 0.466217901633185 2631 6469797 YMR079W SEC14
SGTC_106 0092-0003 11.579 µM -0.0859738507051438 0.498835148336128 no 1683 0.465743602178128 2679 1072148
SGTC_720 r052-1644 49.9 µM -0.0865417666150163 0.498615660282177 no 1684 0.465517877817776 2627 1422863 YOR257W CDC31
SGTC_2443 5493264 126.67 µM -0.0869587119142133 0.498454519589742 no 1685 0.465352165428027 2635 5340055
SGTC_689 0833-0039 98 µM -0.0870983982027791 0.498400533797508 no 1686 0.465296649298891 2615 5374726
SGTC_1077 5-fluorocytosine 377 nM -0.088026563535878 0.49804181834423 no 1687 0.464927781720039 2642 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0910408802067166 0.496876863776394 no 1688 0.463730054103255 2552 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2316 5844804 197.44 µM -0.0914151508724458 0.496732219607641 no 1689 0.46358136175026 2639 776813
SGTC_2036 5160441 105 µM -0.0916549369782377 0.49663954983394 no 1690 0.463486100851286 2595 134534 YIL048W NEO1
SGTC_1307 1187-1599 12.2 µM -0.0919165146272732 0.496538458522447 no 1691 0.463382185116248 2571 1538471
SGTC_2735 sertaconazole 140 nM -0.0927395430854458 0.496220386090262 no 1692 0.463055240762296 2562 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1454 4239-0054 42.6 µM -0.0931721071975558 0.496053215762661 no 1693 0.462883416604095 2742 1340767
SGTC_75 0159-0059 199.013 µM -0.0932143651166453 0.496036884647549 no 1694 0.462866631182501 2628 5377270
SGTC_174 3553-0389 74.3 µM -0.0936013231661124 0.495887340055964 no 1695 0.462712929248138 2676 738071
SGTC_9 0092-0002 10.449 µM -0.0937569069717609 0.495827212985013 no 1696 0.462651132044985 2588 759368
SGTC_879 0831-1030 162 µM -0.093867362837221 0.495784526159785 no 1697 0.462607260008214 2582 1549252
SGTC_1691 st019933 84.6 µM -0.0939560687640784 0.495750244860886 no 1698 0.46257202717296 2561 6176082
SGTC_2462 5162487 171.77 µM -0.0945936200147715 0.495503857697202 no 1699 0.462318808801711 2550 2259986
SGTC_2389 9091542 195.52 µM -0.0947972392496027 0.495425167649665 no 1700 0.462237939878923 2637 3626624 YOL127W RPL25
SGTC_3135 9127742 49.47 µM -0.0949628771356822 0.495361155885578 no 1701 0.462172156687947 2664 3643468
SGTC_2240 6690706 185.951 µM -0.0950325036395387 0.495334248337103 no 1702 0.462144504786794 2553 805876
SGTC_753 1322-0200 289 µM -0.0950624499200815 0.495322675437465 no 1703 0.462132611791652 2697 5403907
SGTC_1068 loratadine 26.9 µM -0.0952803141141621 0.495238480778215 no 1704 0.462046089284828 2628 3957 A H1 histamine antagonist.
SGTC_1093 fluphenazine 7.97 µM -0.0955015398873933 0.495152987237685 no 1705 0.461958233599516 2588 6602611 An atypical antipsychotic.
SGTC_700 3453-2283 142 µM -0.0956363638783585 0.49510088410309 no 1706 0.46190469167885 2681 565664
SGTC_949 1165-0505 146 µM -0.095730188728974 0.495064625258184 no 1707 0.461867431931865 2577 6244267
SGTC_2361 9034121 116 µM -0.095944252229009 0.494981900043793 no 1708 0.461782424237135 2614 6496917
SGTC_3316 9136639 10.545 µM -0.09890645700398 0.493837174538919 no 1709 0.460606271049872 2670 4903665
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0995346150959522 0.493594432977369 no 1710 0.460356902738249 2679 6708760
SGTC_1266 0828-0227 32.9 µM -0.0997214698242452 0.49352222643551 no 1711 0.460282727524131 2667 3913820
SGTC_1602 st001878 87.6 µM -0.100126273462942 0.493365798313323 no 1712 0.460122038466779 2775 595405 YLR310C CDC25
SGTC_22 0964-0034 14.468 µM -0.101566588651735 0.492809226280029 no 1713 0.459550350328652 2619 138402
SGTC_2346 9031566 143.75 µM -0.103177063309364 0.492186917209722 no 1714 0.458911221785325 2688 4771086
SGTC_1807 st050092 58.9 µM -0.103414428104368 0.492095197831621 no 1715 0.458817030785278 2608 5008496
SGTC_1587 estradiol valerate 56.1 µM -0.104159677445292 0.491807231134344 no 1716 0.458521316298855 2598 13791 A steroid.
SGTC_2894 9048625 32.47 µM -0.105177013972426 0.491414136011855 no 1717 0.458117674868204 2645 4092861
SGTC_3148 9097893 49.47 µM -0.107044255951048 0.490692662497605 no 1718 0.457376935129979 2624 17174100
SGTC_953 1188-0045 9.7 µM -0.108275076150584 0.490217109051783 no 1719 0.456888746358633 2696 6144426
SGTC_945 3381-0768 11.3 µM -0.108479959449641 0.490137949382789 no 1720 0.456807488367723 2620 1126236 YIL048W NEO1
SGTC_3210 9128157 49.47 µM -0.108617586496598 0.490084775371607 no 1721 0.456752905638598 2750 17590849
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.108650072982806 0.490072223818072 no 1722 0.456740021654385 2575 2346 DNA damaging agent; causes G2/M arrest.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.110259049196797 0.489450588619947 no 1723 0.456101966598871 2716 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_999 SEC7.066 22.7 µM -0.110301352950811 0.489434244713402 no 1724 0.456085192156597 2626 740511 YDR170C SEC7
SGTC_2782 7736369 71.43 µM -0.110333495980755 0.489421826378718 no 1725 0.456072446734845 2642 2950836 YOL077C BRX1
SGTC_2197 6588183 93.1375 µM -0.112296326159031 0.488663514457938 no 1726 0.455294227340144 2617 884136
SGTC_29 0299-0004 12.984 µM -0.112351747026456 0.488642103964784 no 1727 0.455272256649686 2599 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1704 st028805 70.8 µM -0.112766994192953 0.488481684449907 no 1728 0.455107643104134 2631 2876101
SGTC_2673 kobusone 100 µM -0.114208173988216 0.487924938226702 no 1729 0.454536386201861 2612 6710676 An epoxy ketone and protein crosslinker.
SGTC_2138 5575593 77.673 µM -0.114539411666143 0.487796980153269 no 1730 0.454405102983997 2608 762213
SGTC_2185 6113692 200 µM -0.114746047238044 0.487717156869344 no 1731 0.454323207265946 2706 874150
SGTC_2513 baicalein 25.65 µM -0.114848768194966 0.487677475965228 no 1732 0.454282496670063 2647 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2265 7929201 200 µM -0.114854986694376 0.487675073775019 no 1733 0.454280032156095 2583 1265108
SGTC_1648 st011736 69.8 µM -0.115000116821369 0.487619010510194 no 1734 0.454222514724366 2723 2855514
SGTC_1557 sumaresinolic acid 42.3 µM -0.115850987867578 0.48729032693357 no 1735 0.453885320029539 2593 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.116195670818164 0.487157181557749 no 1736 0.453748733850165 2791 165506
SGTC_2622 2-methoxyxanthone 59.94 µM -0.116283769648275 0.487123150652376 no 1737 0.453713824144705 2692 71034 A hepatoprotective.
SGTC_2739 tacrine 100.86 µM -0.117446458517885 0.486674034896334 no 1738 0.453253135107117 2703 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_507 nimesulide 162 µM -0.117588023565612 0.48661935323006 no 1739 0.453197047458126 2794 4495 A COX2 inhibitor.
SGTC_2002 4023503 131 µM -0.118595699398983 0.486230130346582 no 1740 0.452797836344324 2615 4736863 YCR052W RSC6
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.120216920316217 0.485603948433153 no 1741 0.45215565725353 2720 6708739 YPR165W RHO1
SGTC_1377 2944-0135 198 µM -0.120645918018354 0.485438257827285 no 1742 0.451985748566357 2694 1894137
SGTC_2704 st078022 71.1 µM -0.12087487522061 0.485349829342122 no 1743 0.451895071450055 2724 54697681
SGTC_2620 irigenin 100 µM -0.12154704371644 0.485090226741245 no 1744 0.451628877694801 2710 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_431 k089-0097 107 µM -0.121625415693441 0.485059958595518 no 1745 0.451597842052732 2609 5499420
SGTC_2799 7812892 81.82 µM -0.122835794786325 0.484592507509512 no 1746 0.451118564373455 2731 20205235
SGTC_1221 2958-7315 257 µM -0.122900314813401 0.484567590320914 no 1747 0.451093018166238 2708 4562705
SGTC_2974 9094440 9.66 µM -0.122929640784999 0.484556264853251 no 1748 0.451081406840867 2841 25236134
SGTC_1224 0823-0416 294 µM -0.123501661015105 0.484335357484576 no 1749 0.450854929530907 2739 3598164
SGTC_202 3594-0513 34.79 µM -0.124319948100584 0.484019353178195 no 1750 0.450530976761784 2595 708429
SGTC_1486 3970-0793 4.53 µM -0.125103500189368 0.483716772160908 no 1751 0.450220806159422 2725 2844330
SGTC_1116 jasmonic acid 1.58368 µM -0.126638123393199 0.483124180496423 no 1752 0.449613410868544 2766 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1379 2144-0755 36.5 µM -0.127000187972064 0.482984375373699 no 1753 0.44947012488718 2695 5392327
SGTC_2175 5807670 165.306 µM -0.127319585267674 0.482861047238158 no 1754 0.449343729825383 2645 241186
SGTC_2960 9079389 5.97 µM -0.130078382005057 0.481795868969528 no 1755 0.448252206724988 2713 16457355
SGTC_2592 piperlongumine 83.33 µM -0.130900791496563 0.481478359421265 no 1756 0.447926894273777 2728 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3195 9113082 49.47 µM -0.13146121271273 0.48126200301523 no 1757 0.447705234002766 2615 17018038
SGTC_2404 5161160 200 µM -0.131554834853459 0.481225859755914 no 1758 0.447668205750796 2616 2831543
SGTC_1039 k821-0043 94 µM -0.132237006563531 0.480962508898029 no 1759 0.447398415561227 2633 15992768
SGTC_1548 st061468 90.8 µM -0.132397034355917 0.48090073172673 no 1760 0.447335130134867 2709 390799
SGTC_682 0kpi-0099 17 µM -0.133871678703339 0.480331481411633 no 1761 0.44675202289247 2741 1714895 YML126C ERG13
SGTC_1430 4049-0248 69.1 µM -0.134668651573935 0.48002384618611 no 1762 0.446436929890061 2739 22774488
SGTC_711 k292-0785 179 µM -0.135248429280475 0.479800056767195 no 1763 0.446207728897651 2625 4146315
SGTC_2543 pimpinellin 60.67 µM -0.136572872702218 0.479288856515019 no 1764 0.445684209997218 2645 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3061 glucosamine 200 µM -0.137220600012625 0.479038863197327 no 1765 0.445428214237193 2632 91431 and experimental redox chemotherapeutic
SGTC_3137 9097352 49.47 µM -0.137274883787122 0.47901791249943 no 1766 0.445406761154177 2915 44120435
SGTC_3265 9137266 49.47 µM -0.138354945570569 0.478601077266003 no 1767 0.444979951359128 2616 17224265
SGTC_912 3474-0017 2.18 µM -0.139208682604327 0.478271605547545 no 1768 0.444642623793052 2803 3360550
SGTC_742 0kpi-0133 140 µM -0.139613859612486 0.478115245994371 no 1769 0.444482544745947 2787 2728852
SGTC_3193 9111931 49.47 µM -0.139995740226506 0.477967879703174 no 1770 0.44433167802553 2669 17087244
SGTC_512 prima-1 270 µM -0.141068180785004 0.477554045102648 no 1771 0.443908040147182 2817 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_984 1492-0255 2.91 µM -0.141663911389089 0.47732417431734 no 1772 0.443672740962404 2801 1585198
SGTC_2805 7950783 58.44 µM -0.143182126801616 0.476738384468682 no 1773 0.443073172559494 2773 1178958 YDL195W SEC31
SGTC_635 k038-0028 24.7 µM -0.14322825777486 0.476720586025368 no 1774 0.443054956707597 2685 4035102
SGTC_1339 1486-1321 22.7 µM -0.143974934505259 0.476432506598457 no 1775 0.442760131380588 2683 3469382
SGTC_696 1560-0013 611 µM -0.144531102427471 0.476217936411017 no 1776 0.442540549047819 2826 1650269
SGTC_2136 5328288 199.296 µM -0.146307094342582 0.475532803276314 no 1777 0.441839482824538 2694 262395
SGTC_1556 plumbagin 1.48 µM -0.146827945899797 0.47533188543753 no 1778 0.441633913048526 2656 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_681 1642-0006 26.6 µM -0.147001291170078 0.475265019104321 no 1779 0.4415655005934 2661 4446530
SGTC_1571 st070080 73.4 µM -0.147261917506303 0.475164486219668 no 1780 0.441462645068872 2793 4315245
SGTC_1285 0929-0069 65.5 µM -0.147695591884665 0.474997206033417 no 1781 0.441291505324756 2709 1206237
SGTC_1123 mangostin 811.285 nM -0.147981841830227 0.474886793935759 no 1782 0.441178549288306 2760 5281650 An antioxidant.
SGTC_2986 9022445 71.43 µM -0.148109622401855 0.474837507139071 no 1783 0.441128127811802 2819 6459286
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.148758691802749 0.474587157736114 no 1784 0.440872023521314 3028 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1392 3455-1037 33.9 µM -0.149127443029672 0.474444932956552 no 1785 0.440726535802324 2808 981132
SGTC_732 3970-1727 52.7 µM -0.149749317993505 0.474205087501647 no 1786 0.440481198358163 2781 1275699
SGTC_978 1416-0512 87.4 µM -0.151035048328861 0.473709235284037 no 1787 0.439974034224956 2708 6814003
SGTC_3058 9093861 49.47 µM -0.151639977925568 0.473475953375354 no 1788 0.439735450090619 2818 17217477
SGTC_1244 0416-0015 52.5 µM -0.152413010692672 0.473177858282239 no 1789 0.439430597956708 2695 96201
SGTC_1174 0739-0097 51.1 µM -0.152687615864513 0.47307196928306 no 1790 0.43932231367662 2727 728447
SGTC_1469 k284-2957 126 µM -0.153406363434327 0.472794825988821 no 1791 0.439038913495534 2703 23884841
SGTC_51 1013-0126 23.419 µM -0.154289566690231 0.472454287950038 no 1792 0.438690711694795 2738 1627850
SGTC_2191 5911152 200 µM -0.154327574677218 0.472439633602079 no 1793 0.438675728155462 2702 2875902
SGTC_1596 piperlongumine 63 µM -0.154846632917136 0.472239509406113 no 1794 0.43847111340153 2847 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_833 3852-0053 558 µM -0.155251864669976 0.472083276164211 no 1795 0.438311380914799 2835 3123681
SGTC_3293 9120939 62.045 µM -0.155831697872569 0.471859734472833 no 1796 0.438082842272096 2817 934087
SGTC_2320 7373003 200 µM -0.155917145409564 0.471826792838405 no 1797 0.438049165254507 2725 5415828
SGTC_961 1252-1571 372 µM -0.156113660082875 0.471751033463299 no 1798 0.437971715595497 2805 6813498
SGTC_395 anisomycin 6.25 µM -0.156135706131024 0.471742534442426 no 1799 0.437963027034158 2738 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_483 fpl-64176 144 µM -0.159625990453954 0.470397152031326 no 1800 0.436587852039976 2692 3423
SGTC_2060 5238662 140 µM -0.159690298883949 0.470372366505622 no 1801 0.436562521600046 2789 790130
SGTC_802 4112-3352 742 µM -0.160668483112102 0.469995372436769 no 1802 0.436177256860199 2835 704594
SGTC_2131 toluylene red 5.2905 µM -0.161175201885223 0.469800092607068 no 1803 0.435977705889036 2728 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.162115579893181 0.469437707994896 no 1804 0.435607418754017 2827 6728940
SGTC_596 1155-0152 116 µM -0.162183541050823 0.469411519421226 no 1805 0.435580660270672 2681 280313
SGTC_2646 retinol 96.75 µM -0.163722422149421 0.468818553083015 no 1806 0.434974832701888 2774 445354 A vitamin A analog and teratogen.
SGTC_1613 st002381 52.1 µM -0.164004743273077 0.468709775719505 no 1807 0.434863704891246 2705 551167
SGTC_2630 antimycin a 100 µM -0.164297659053904 0.468596918739881 no 1808 0.43474841222895 2649 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1743 st037606 46.3785 µM -0.164475640963059 0.468528345651086 no 1809 0.434678360644503 2717 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1880 MG-132 525 µM -0.164549519241137 0.468499882011377 no 1810 0.434649283625997 2770 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_3339 9145883 14.936 µM -0.165164841929987 0.468262818281527 no 1811 0.434407118620678 2809 2030670
SGTC_964 1287-0107 19.4 µM -0.165624373311837 0.468085783188513 no 1812 0.434226282537122 2822 51516812 YPR165W RHO1
SGTC_3237 9133362 49.47 µM -0.166217619601599 0.467857243582745 no 1813 0.433992846944326 2790 43845137
SGTC_1009 4106-0057 9.87 µM -0.166852428594344 0.467612704278046 no 1814 0.433743082400802 2694 2928005
SGTC_3182 9108849 49.47 µM -0.167003664837637 0.467554447284209 no 1815 0.433683582650328 2775 17133045
SGTC_1986 st071812 45 µM -0.167542282806901 0.467346974471838 no 1816 0.433471690403901 2710 11838594
SGTC_263 alizarin 107.927 µM -0.167858860683706 0.467225034472191 no 1817 0.433347157622032 2677 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_986 1493-0483 84 µM -0.168640349379116 0.46692403253255 no 1818 0.433039770430914 2701 40079
SGTC_2769 toremifene 3.73 µM -0.169261023974942 0.466684983992328 no 1819 0.43279566597584 2879 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_939 1165-0479 45.3 µM -0.16983436227173 0.466464177376459 no 1820 0.432570201145974 2736 1377347
SGTC_1887 st057648 70.8 µM -0.169851407042708 0.466457613175477 no 1821 0.432563498638989 2855 688672
SGTC_79 0052-0007 94.094 µM -0.170146934005409 0.466343802691817 no 1822 0.432447291801944 2873 2801472
SGTC_1384 3089-0840 101 µM -0.17032798576571 0.466274079149077 no 1823 0.432376101683136 2782 1069836
SGTC_2610 ononetin 44.17 µM -0.17042982082167 0.466234862636944 no 1824 0.432336060784928 2780 259632
SGTC_2793 7325131 81.82 µM -0.170799105442594 0.466092654491108 no 1825 0.432190866246014 2794 4176441
SGTC_1290 0986-0249 10.2 µM -0.171614368608696 0.46577871942176 no 1826 0.43187035526727 2763 53329
SGTC_1234 0326-0494 15.5 µM -0.172833776551519 0.465309199294103 no 1827 0.431391043350723 2851 1547813
SGTC_595 3909-8003 73.7 µM -0.173541931258755 0.465036553938961 no 1828 0.431112735740646 2813 699517
SGTC_2730 imipramine 71.33 µM -0.174325116381894 0.464735040379019 no 1829 0.430804980712691 2725 3696 A tricyclic antidepressant.
SGTC_2840 9008771 71.43 µM -0.174437921176807 0.464691614028146 no 1830 0.430760657175235 2880 2992978
SGTC_2055 5235184 200 µM -0.175174834357645 0.464407935657159 no 1831 0.430471128919386 2868 2836034
SGTC_704 1310-0270 142 µM -0.175415682901427 0.464315223735591 no 1832 0.430376509234726 2796 5718033
SGTC_1160 4092-0570 10.5 µM -0.175449724978573 0.464302119779368 no 1833 0.430363135797106 2704 4994975
SGTC_810 3825-7150 143 µM -0.176360870399699 0.463951403272408 no 1834 0.430005221841895 2878 22330411 YGL099W LSG1
SGTC_2518 prenyletin 46.28 µM -0.17770401289762 0.463434454360892 no 1835 0.429477716787885 2782 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2033 5192550 145 µM -0.177779871189718 0.463405259842284 no 1836 0.429447927990692 2752 182073
SGTC_3258 9138477 49.47 µM -0.178127008105586 0.463271664635379 no 1837 0.429311615902767 2743 4970355
SGTC_3129 9127257 49.47 µM -0.178321369912716 0.46319686654538 no 1838 0.429235298504113 2752 837894
SGTC_657 3534-0529 86.7 µM -0.178643366349885 0.4630729524797 no 1839 0.429108870379029 2882 1049549
SGTC_1855 st056195 39.6 µM -0.179148470396941 0.462878580235061 no 1840 0.428910561854325 2901 4028379
SGTC_907 3448-6986 75.5 µM -0.18031826186624 0.46242845957841 no 1841 0.428451359877142 2857 590582
SGTC_937 3122-0005 46.7 µM -0.180919399838904 0.462197168123918 no 1842 0.428215420628422 2886 759535
SGTC_463 ikarugamyin 104 µM -0.181053097177639 0.462145729002662 no 1843 0.428162949555061 2709 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2355 9061122 103.12 µM -0.181359075685417 0.462028008283689 no 1844 0.428042869517081 2857 5302957
SGTC_1874 staurosporine 7.6 µM -0.182484189535942 0.461595166002567 no 1845 0.427601380481363 2854 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2232 chlorophetanol 41.5365 µM -0.182725570456032 0.461502310314944 no 1846 0.427506675607964 2738 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_499 genistein 192 µM -0.183798178738396 0.461089719145654 no 1847 0.427085892477503 2790 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2293 7624732 200 µM -0.18462814200606 0.460770492902312 no 1848 0.426760355636247 2705 894453
SGTC_183 3914-0051 30.55 µM -0.185178525976035 0.460558814320146 no 1849 0.426544505793166 2855 1596232
SGTC_2433 5607874 27.82 µM -0.185212992487215 0.460545558814369 no 1850 0.42653098943194 2735 2252428
SGTC_1657 st012939 43.4 µM -0.1852248756296 0.460540988676375 no 1851 0.426526329367718 2878 24207257
SGTC_2661 dactinomycin 12.96 µM -0.185400533206626 0.46047343313324 no 1852 0.426457445116239 2725 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1187 1391-0724 117 µM -0.185731764487291 0.460346049140236 no 1853 0.426327558624434 2774 6997986
SGTC_2220 6782180 200 µM -0.185807212290709 0.460317034205089 no 1854 0.426297974218769 2739 833803
SGTC_2877 9040724 71.43 µM -0.186094307911394 0.460206627876618 no 1855 0.426185402788681 2932 6463895
SGTC_1989 st071868 50.2 µM -0.186609743893188 0.460008418017701 no 1856 0.425983313216359 2875 16414057
SGTC_365 0121-0052 13.6 µM -0.187181989088566 0.459788373934566 no 1857 0.425758972941378 2866 3101739
SGTC_2200 6600604 21.907 µM -0.188391633656478 0.459323272803625 no 1858 0.425284828826825 2725 2904777
SGTC_2832 7992762 51.95 µM -0.189753291337196 0.458799790166429 no 1859 0.424751229456985 2728 2985177
SGTC_678 1218-2179 85.9 µM -0.190823117017852 0.458388550981496 no 1860 0.424332088356144 2731 6820081 YOR116C RPO31
SGTC_3101 9120531 49.47 µM -0.190850447469462 0.458378045783577 no 1861 0.424321381828108 2980 24824904
SGTC_2163 5671233 125 µM -0.19155947958033 0.458105520305492 no 1862 0.424043642614341 2882 701023
SGTC_329 k048-0121 21.3 µM -0.19189396455606 0.457976963594601 no 1863 0.423912632587992 2829 6832902
SGTC_1907 st060210 83.7 µM -0.191977006351066 0.457945047804251 no 1864 0.423880108340541 2922 688793
SGTC_2522 biochanin a 4.94 µM -0.192665838407425 0.45768031665517 no 1865 0.423610339573293 2871 5280373 A possible chelator.
SGTC_2468 5987765 72.9 µM -0.193414007598007 0.457392802400433 no 1866 0.423317373040068 2792 26772094
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.193788856091128 0.457248760089568 no 1867 0.423170606578016 2942 94937 An inhibitor of serotonin biosynthesis.
SGTC_2564 betulinic acid 100 µM -0.194256607839506 0.45706902590166 no 1868 0.422987480154949 3007 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2659 sanguinarine 24.21 µM -0.194542085175477 0.456959335194989 no 1869 0.422875722967027 2740 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1816 st051957 91.6 µM -0.194787116511042 0.456865187917884 no 1870 0.422779804319212 2780 674121
SGTC_3127 9126946 49.47 µM -0.196892347456232 0.456056404899628 no 1871 0.421955891154539 2848 27243249
SGTC_2467 5474540 200 µM -0.199452774122882 0.455072991445332 no 1872 0.420954290941859 2744 5413519
SGTC_2697 mebhydrolin 72.4 µM -0.199808112478146 0.454936534041246 no 1873 0.420815328213792 2884 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_861 0443-0273 110 µM -0.200617241057749 0.454625831508533 no 1874 0.420498937867754 2851 6149169
SGTC_3272 9137413 49.47 µM -0.200968890370324 0.454490808050054 no 1875 0.420361449826294 2751 17614870
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.202457731815567 0.453919193203609 no 1876 0.419779449626385 3002 6710655
SGTC_1112 tnp00069 1.16933 µM -0.203047644926146 0.453692732630967 no 1877 0.419548896254851 2879 145826
SGTC_846 0335-0850 148 µM -0.20523543696027 0.452852997524943 no 1878 0.418694091999225 2774 6819598
SGTC_1831 st055328 12 µM -0.205980975669461 0.452566887114145 no 1879 0.418402885937049 2927 1103068
SGTC_1438 4092-1045 4 µM -0.206694366471926 0.452293136945355 no 1880 0.418124278652065 2764 1351342
SGTC_2095 5432005 200 µM -0.207604910579721 0.451943765902113 no 1881 0.417768734908796 2791 783734
SGTC_1118 chelidonine 707.474 nM -0.207738420172995 0.451892542086548 no 1882 0.417716608534729 2851 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1722 st034304 3.6505 µM -0.210293455006928 0.450912403539354 no 1883 0.416719321614874 2813 4036148 YLR033W RSC58
SGTC_981 1488-1094 54.9 µM -0.210295648116023 0.450911562367055 no 1884 0.416718465824837 2736 3449522
SGTC_407 eburnamonine 100 µM -0.210857217745297 0.450696178243484 no 1885 0.416499344403938 2755 3195
SGTC_2415 st077333 57.7 µM -0.211095194398561 0.450604909177699 no 1886 0.416406495028788 3023 2766255
SGTC_2017 5132927 60.65 µM -0.212597099446997 0.450028957368444 no 1887 0.415820617017751 2791 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1211 1056-0033 32.3 µM -0.212625741257693 0.450017974801572 no 1888 0.415809445949754 2817 6741922
SGTC_1041 0206-0046 107 µM -0.213114232434029 0.449830671070619 no 1889 0.415618931879736 2868 50494
SGTC_1459 k035-0031 35.7 µM -0.214326070879724 0.44936606032796 no 1890 0.415146394374993 2762 3877128 YMR208W ERG12
SGTC_1968 st069590 43.6 µM -0.214520071193891 0.449291688335909 no 1891 0.415070758355572 2926 6384066
SGTC_3041 9091929 49.47 µM -0.214812754747132 0.449179488493237 no 1892 0.414956654091074 2942 25236887
SGTC_71 0417-1750 47.813 µM -0.215403097322902 0.44895319384172 no 1893 0.41472652768529 3002 6811472
SGTC_112 phenothiazine 287.218 µM -0.215678323170875 0.448847697826014 no 1894 0.414619249578562 2784 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2046 4110841 106 µM -0.216056917528345 0.448702585839399 no 1895 0.414471690683987 2925 44119630 YMR134W ERG29
SGTC_2313 7726885 200 µM -0.216354598307808 0.448588492154966 no 1896 0.41435567670401 2899 726423
SGTC_1212 0520-0165 585 µM -0.216428628305367 0.448560118946657 no 1897 0.414326826438821 3201 5403258
SGTC_1610 st001799 48.1 µM -0.217874452932288 0.44800603591815 no 1898 0.413763466299986 2762 621897
SGTC_3328 9140624 29.0385 µM -0.218155837486789 0.447898212739276 no 1899 0.413653846455933 2960 4904392
SGTC_2965 9082772 38.63 µM -0.218362470739316 0.447819035811706 no 1900 0.413573351990401 2935 16459634
SGTC_880 0833-0487 87.2 µM -0.219334506040629 0.447446603043363 no 1901 0.413194742153441 2802 76075
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.220191289009401 0.447118367309237 no 1902 0.412861090260308 2779 803109
SGTC_81 0411-0046 9.971 µM -0.223543038954195 0.445834653433393 no 1903 0.411556445116236 2792 12925265
SGTC_2408 sulbentine 18.36 µM -0.223562659981242 0.445827140275242 no 1904 0.411548810632424 2874 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_88 0180-0332 8.668 µM -0.22536342299011 0.445137686784897 no 1905 0.410848281986924 2769 3101745
SGTC_1309 pyrazolanthrone 13.4 µM -0.225531500195159 0.445073343932349 no 1906 0.410782911452406 2902 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1494 4358-1428 177 µM -0.22737423591753 0.444368008183845 no 1907 0.410066376209334 2946 1564571
SGTC_3305 9127027 53.8275 µM -0.229622380251464 0.44350773473196 no 1908 0.409192607292709 2853 41905295
SGTC_2602 kawain 100 µM -0.229667211958956 0.443490582153388 no 1909 0.409175187470833 2772 5369129
SGTC_2988 9073640 71.4286 µM -0.23034243472331 0.443232255240493 no 1910 0.408912844421184 3002 9102229
SGTC_2118 5526350 200 µM -0.230704773454027 0.44309364152811 no 1911 0.408772082439598 2933 743594
SGTC_2247 cerulenin 830 nM -0.230950666777891 0.442999578303003 no 1912 0.408676564073393 3033 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1136 pergolide 1.05886 µM -0.231236647947439 0.442890184046017 no 1913 0.408565480226648 2828 47811 A dopamine receptor agonist.
SGTC_1975 st070967 30.8 µM -0.231837159843024 0.442660488860221 no 1914 0.408332246927985 2939 261391
SGTC_590 k048-0076 22.4 µM -0.232083526691269 0.44256625936354 no 1915 0.408236569697696 2935 6832814
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.232086341556016 0.442565182763065 no 1916 0.408235476568974 2945 521171
SGTC_62 0180-0423 3.232 µM -0.232723646022532 0.442321444048803 no 1917 0.407988003213637 2843 30102 YGL099W LSG1
SGTC_792 4534-1957 155 µM -0.23360261257946 0.441985316891944 no 1918 0.407646749658592 2869 1717904
SGTC_2303 7774051 200 µM -0.235427525808517 0.441287582246812 no 1919 0.406938461938121 3004 2953184
SGTC_1933 st074711 15.9 µM -0.235504102395352 0.441258308034724 no 1920 0.40690874756813 2774 17250958
SGTC_2171 5739187 198.077 µM -0.235536315532336 0.441245993476187 no 1921 0.406896247914522 2761 2262761
SGTC_1277 0873-0036 22 µM -0.235869249702036 0.44111872148561 no 1922 0.406767065129008 2906 5965735
SGTC_480 am 92016 50 µM -0.236048163255321 0.441050330043275 no 1923 0.406697648534241 2873 2129 K+ channel blocker.
SGTC_1750 st081859 2.357 µM -0.236517312463131 0.440871001558973 no 1924 0.406515637456816 2854 5291695
SGTC_2414 st077232 92.9 µM -0.238822322172944 0.439990107074651 no 1925 0.405621680207196 2802 729801
SGTC_3324 9138759 60.749 µM -0.238994882430153 0.439924172445094 no 1926 0.405554775501887 2960 45595710
SGTC_2388 9080168 200 µM -0.243077976214515 0.43836452766267 no 1927 0.403972496025489 2825 15943073
SGTC_169 k015-0017 16.025 µM -0.245305788015632 0.437513958369461 no 1928 0.403109835228961 3038 1840002
SGTC_2777 climbazole 1.536 µM -0.245653385738371 0.437381272937881 no 1929 0.402975279670169 2894 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3068 9116768 49.47 µM -0.246310940681371 0.437130289526619 no 1930 0.402720770679638 2939 41904888
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.24730015471091 0.436752762210886 no 1931 0.402337969532002 2964 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1271 0832-2808 169 µM -0.247374204597689 0.436724503850003 no 1932 0.402309317836017 2991 3663794
SGTC_1043 0916-0009 19.3 µM -0.250890572504991 0.435382988214657 no 1933 0.400949356700609 3049 3101130
SGTC_485 niflumic acid 177 µM -0.251377557284518 0.43519725882603 no 1934 0.400761108714753 2965 4488 A COX2 inhibitor.
SGTC_2084 5306078 60.6385 µM -0.252467039261186 0.434781797006325 no 1935 0.400340043970036 2913 679340
SGTC_1979 st071809 45.3 µM -0.253938688680136 0.434220714287434 no 1936 0.399771462481979 2987 4976333
SGTC_1694 st024011 44.9 µM -0.255141671002882 0.433762162250086 no 1937 0.39930684005982 2873 2787533
SGTC_2931 9014674 55.67 µM -0.25520418559487 0.433738335408675 no 1938 0.399282699223582 2870 2996810
SGTC_269 exalamide 29 µM -0.255847954535015 0.433492983030047 no 1939 0.399034121756046 2877 3316 A derivative of salicylamide.
SGTC_1471 k673-0312 37 µM -0.256559479160862 0.433221837511603 no 1940 0.398759429527248 2904 24099884
SGTC_3108 9121785 49.47 µM -0.257383779901516 0.432907754940029 no 1941 0.39844126148721 2784 17140271
SGTC_727 3032-0951 202 µM -0.258113403160185 0.432629782594917 no 1942 0.398159693877655 2935 3652836
SGTC_2939 9044578 71.43 µM -0.260951472586421 0.431548851328509 no 1943 0.397064965087725 2837 2653634
SGTC_773 4358-1457 44.6 µM -0.261751198050902 0.431244353266706 no 1944 0.39675663291611 3049 1186886
SGTC_350 k064-0020 19.8 µM -0.261866345051206 0.431200514034062 no 1945 0.396712243586101 3071 2790705
SGTC_119 0121-0043 24.815 µM -0.263252370516512 0.430672887457217 no 1946 0.39617803400448 2859 1092378
SGTC_1262 0737-0114 49.6 µM -0.263398132088786 0.430617406704585 no 1947 0.396121865083742 3016 765919
SGTC_591 4299-0174 154 µM -0.263738619020392 0.430487813610021 no 1948 0.395990667552071 2919 5509088
SGTC_2927 9011802 47.9 µM -0.263839627128316 0.430449370245419 no 1949 0.395951749044685 2983 43912568
SGTC_83 0170-0301 39.027 µM -0.264927722283394 0.430035286561034 no 1950 0.395532570923636 2851 3089716
SGTC_2285 7945142 200 µM -0.265182179369324 0.429938461878922 no 1951 0.395434561209119 2989 2970608
SGTC_2162 5663267 200 µM -0.26563449421534 0.429766359799776 no 1952 0.395260358578477 3026 6456493
SGTC_1185 1319-0113 81.3 µM -0.266745392015036 0.429343729026621 no 1953 0.39483260098188 2980 4672763
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.267625003632659 0.429009146355491 no 1954 0.394493991342264 2985 7104
SGTC_2748 diazoxide 86.69 µM -0.268393924135099 0.428716709638155 no 1955 0.394198057923065 2960 3019 A potassium channel activatior.
SGTC_608 k048-0125 159 µM -0.268898845885814 0.428524698499903 no 1956 0.394003762561212 2999 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_967 1306-0166 352 µM -0.269103593390749 0.428446842142031 no 1957 0.393924982638708 3041 4437607
SGTC_3257 9139206 32.98 µM -0.269591858089596 0.428261188065841 no 1958 0.393737132401763 3000 4910041
SGTC_422 cantharidin 155 µM -0.270657135946191 0.427856190033114 no 1959 0.393327373581504 2841 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2274 7947094 46.08 µM -0.270916570807608 0.427757569408866 no 1960 0.39322759990764 2882 2971028
SGTC_3003 9075612 71.4286 µM -0.271621799221343 0.42748950927184 no 1961 0.392956418037402 2956 6501993
SGTC_2706 st078239 82.5 µM -0.271894210972178 0.427385973431932 no 1962 0.392851681296868 2882 15434492
SGTC_2570 licareol 100 µM -0.273622225755811 0.426729321680412 no 1963 0.392187475966961 2960 443158
SGTC_2580 diallyl disulphide 81.36 µM -0.273812766454073 0.426656927933161 no 1964 0.392114256110854 2893 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_472 calcifediol 10 µM -0.274690579213659 0.426323445016439 no 1965 0.391776984774055 2957 5283731 A vitamin D metabolite.
SGTC_3175 9106517 49.47 µM -0.275635296698395 0.425964603705861 no 1966 0.391414098302048 2969 41468073
SGTC_1258 0671-0043 57.1 µM -0.27675506759349 0.425539349549392 no 1967 0.390984092408453 2956 4298767
SGTC_3021 9087658 49.47 µM -0.277144257641194 0.425391567530009 no 1968 0.390834669786194 2960 25237042
SGTC_40 0327-0103 19.753 µM -0.277260363913521 0.425347482050844 no 1969 0.390790095960532 2923 409036
SGTC_3184 9108758 49.47 µM -0.278313176202505 0.424947772551797 no 1970 0.390385981194266 2837 902885
SGTC_551 k048-0028 34.9 µM -0.278443916334046 0.424898141281006 no 1971 0.390335805748296 3057 6836383
SGTC_2487 5918373 44.05 µM -0.28022588416746 0.424221793723793 no 1972 0.389652104597166 2957 2876279
SGTC_2768 sulfasalazine 50.2 µM -0.280326078826374 0.424183771353798 no 1973 0.389613672267011 3023 5384001 An antioxidant and salicylic acid derivative.
SGTC_2797 7859098 81.82 µM -0.281017344510316 0.423921465643713 no 1974 0.389348548334792 2919 972681
SGTC_1738 st035555 74 µM -0.281264170938231 0.423827813748888 no 1975 0.389253894464229 3008 5331140
SGTC_47 0149-0135 24.25 µM -0.281629293012584 0.423689285525351 no 1976 0.389113888212313 2884 5239155
SGTC_569 4130-2812 160 µM -0.281943903460941 0.42356992910151 no 1977 0.388993262215765 2904 743552
SGTC_3136 9095672 49.47 µM -0.282454794742188 0.423376122903891 no 1978 0.388797402232827 2810 17217380
SGTC_1688 st021091 57.6 µM -0.283354849205659 0.423034733089506 no 1979 0.388452417851995 3039 3656366
SGTC_2983 9022671 12.99 µM -0.283666320944012 0.422916605596743 no 1980 0.388333053458605 3100 6405161
SGTC_1606 st000094 49.2 µM -0.284007289298027 0.422787299284906 no 1981 0.388202397255992 3051 1242210
SGTC_1207 2099-0101 141 µM -0.285652123041713 0.422163641825333 no 1982 0.387572288789956 3015 5837381
SGTC_2614 arthonioic acid 13.39 µM -0.28599702850242 0.422032891683841 no 1983 0.387440198728892 2871 6710684
SGTC_1696 st025591 34.7925 µM -0.287491993514523 0.421466265220642 no 1984 0.38686781578122 2912 2787147
SGTC_136 0097-0015 404.482 µM -0.287603280021416 0.42142409153732 no 1985 0.386825216913922 2935 4861337
SGTC_1177 0983-0204 23.6 µM -0.28855241750062 0.421064438394366 no 1986 0.386461956248014 3069 766818
SGTC_2838 9002687 71.43 µM -0.289538143629071 0.420690990571023 no 1987 0.386084797418032 2887 6457060
SGTC_2850 9015429 58.44 µM -0.2896948964517 0.420631610460751 no 1988 0.386024830515349 2973 6457570
SGTC_410 α-linolenic acid 100 µM -0.291095943417355 0.420100955093668 no 1989 0.385488971170306 3036 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_459 nigericin 15.3 µM -0.291521281245524 0.419939884400942 no 1990 0.385326335125704 3039 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3307 9126885 69.2785 µM -0.2918131174423 0.419829377042381 no 1991 0.385214757643092 2916 24824909
SGTC_1965 Pectolinarigenin 58.4 µM -0.292489692591824 0.419573207885003 no 1992 0.384956119810119 2926 5320438 An anti-inflammatory.
SGTC_3250 9135583 49.47 µM -0.293059709604627 0.419357410889591 no 1993 0.384738256216626 3064 7699353
SGTC_2555 cholic acid 100 µM -0.293415416433515 0.419222759712252 no 1994 0.384602321573496 3079 6708657 Influences liver metabolism.
SGTC_2657 nystatin 74.44 µM -0.294101944003096 0.418962904632956 no 1995 0.384340002722654 2982 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1520 flindersine 88 µM -0.294619877616664 0.418766886832556 no 1996 0.384142137845603 3196 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1497 4476-2978 41.3 µM -0.294718748019679 0.41872947050749 no 1997 0.384104370064154 3009 1528379
SGTC_109 0132-0036 33.701 µM -0.295205647536327 0.41854521992283 no 1998 0.383918394018392 2877 67274 A color developer.
SGTC_2623 humulene 100 µM -0.296074732103456 0.418216388825372 no 1999 0.38358650510552 3011 6187145 An anti-inflammatory.
SGTC_859 0439-0102 54.6 µM -0.296167329531485 0.41818135657382 no 2000 0.383551148720455 3065 610143
SGTC_2897 9048598 12.99 µM -0.296284414531737 0.418137060903642 no 2001 0.383506443657897 2931 6467404
SGTC_1591 genipin 88.4 µM -0.298132471345679 0.417438040790368 no 2002 0.382801029630747 3058 442424 A DNA cross-linking agent.
SGTC_1159 4092-0538 61.2 µM -0.298458818903323 0.417314628164455 no 2003 0.382676501174004 2943 717301
SGTC_179 1273-0063 6.77 µM -0.298933888847927 0.417134988772 no 2004 0.382495244566673 2918 3108139
SGTC_1311 1190-0148 100 µM -0.299710862910299 0.416841226911657 no 2005 0.382198855955277 3064 1961333
SGTC_2852 9023854 51.95 µM -0.301160514176126 0.416293260458726 no 2006 0.381646048982561 3091 19798528
SGTC_2780 5215298 71.43 µM -0.30124449494037 0.416261520804021 no 2007 0.381614031318012 3087 2834131
SGTC_2032 5185112 25.99 µM -0.301924231354832 0.416004641623604 no 2008 0.381354911652894 2991 5718189
SGTC_2508 celastrol 40.54 µM -0.30225807761804 0.415878490918067 no 2009 0.381227666886382 2958 122724 Celastrol is a natural product and antioxidant.
SGTC_479 n-linoleoylglycine 10 µM -0.302440033479434 0.415809738786461 no 2010 0.381158320216424 2951 6433346 An anti-infammatory.
SGTC_2451 5856223 45.7 µM -0.302823808527966 0.415664737605084 no 2011 0.381012069118795 2974 2179896
SGTC_2421 5690543 90.72 µM -0.304109899855179 0.415178899368362 no 2012 0.380522082414229 3039 3397993
SGTC_1996 st072960 66.8 µM -0.304399713054076 0.415069436424519 no 2013 0.380411693187656 3070 1719405
SGTC_1771 st048882 4.1505 µM -0.304520970183185 0.415023639354004 no 2014 0.380365509496001 2928 4580403
SGTC_3188 9110789 49.47 µM -0.305110393772154 0.414801039016875 no 2015 0.380141037660453 3116 849217
SGTC_3352 9151559 45.5865 µM -0.305694566167339 0.414580448822124 no 2016 0.379918605478927 3025 17159339
SGTC_1727 st034309 9.9045 µM -0.307127337086672 0.414039532279682 no 2017 0.379373225310732 3199 870305
SGTC_1732 st034308 51.822 µM -0.307660298867085 0.41383836382148 no 2018 0.379170416099398 2863 830119
SGTC_1501 4491-0275 38.4 µM -0.312197082460577 0.412126858060116 no 2019 0.377445374619834 3065 5104718
SGTC_2037 5169046 200 µM -0.313580123471707 0.411605435215033 no 2020 0.376919978894637 3059 5718022
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.314043064125244 0.411430935922147 no 2021 0.376744165800028 2935 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_927 2425-1185 123 µM -0.314484324230701 0.411264625128965 no 2022 0.376576610217096 2923 730375
SGTC_2123 5259487 200 µM -0.315278670646858 0.410965276425488 no 2023 0.376275039082831 3075 2173474
SGTC_3356 9151811 4.48 µM -0.31572679441259 0.410796424265105 no 2024 0.376104943602362 2955 1859254 YPR165W RHO1
SGTC_2664 lyso-paf C-16 73.48 µM -0.316674808529178 0.4104392689034 no 2025 0.375745182807196 2958 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_451 chloral hydrate 100 µM -0.316755497185516 0.410408873639647 no 2026 0.375714567343769 3085 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_15 0266-0086 27.098 µM -0.318463042487513 0.409765771033327 no 2027 0.375066862143035 3059 1712902 YIL048W NEO1
SGTC_386 1509-0011 3.07 µM -0.318489535180739 0.409755795155602 no 2028 0.375056815717922 2958 3107280
SGTC_1003 4049-0218 100 µM -0.319528699505633 0.409364541857056 no 2029 0.374662816015793 3127 295161
SGTC_3221 9128209 49.47 µM -0.319719265587615 0.409292802055472 no 2030 0.374590576966994 2997 16460723
SGTC_2608 thymoquinone 42.66 µM -0.320327871417043 0.409063708912004 no 2031 0.374359898522271 3047 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1545 lovastatin 49.4 µM -0.320364879243634 0.409049779321237 no 2032 0.374345872981807 3042 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_433 pimozide 108 µM -0.321354436126839 0.408677356909166 no 2033 0.373970904032596 2911 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1744 st037937 38.9 µM -0.322362332200283 0.408298117246023 no 2034 0.373589108442588 3163 1016152
SGTC_272 doxorubicin 8.13 µM -0.324081049479094 0.407651616122972 no 2035 0.372938336833793 2966 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3089 9117425 49.47 µM -0.324495562906078 0.407495733105246 no 2036 0.372781440487145 3029 9401657
SGTC_1854 st056233 32.9 µM -0.324921885791879 0.407335424269828 no 2037 0.372620096187419 3073 5393174
SGTC_2784 7567673 72.73 µM -0.325418027644137 0.407148881172131 no 2038 0.372432356645761 2981 3471247
SGTC_370 0180-0345 38.7 µM -0.326119452386644 0.406885190230039 no 2039 0.3721669900035 2896 3989527
SGTC_1841 st054148 70 µM -0.32614024839087 0.406877372903181 no 2040 0.372159123277302 3059 675442
SGTC_1208 2323-2347 50.3 µM -0.326386137927806 0.406784944552705 no 2041 0.372066112066963 3134 5412760
SGTC_2170 morpholine 200 µM -0.327040295652067 0.406539076018398 no 2042 0.371818703972181 3097 121171 Reacts with secondary amines.
SGTC_1774 st048371 48.465 µM -0.327288692071908 0.406445724595958 no 2043 0.371724772161705 2964 4242727
SGTC_1723 st034307 2.5525 µM -0.329113202233914 0.405760207232164 no 2044 0.371035062838726 3055 867466
SGTC_2491 paeonol 100 µM -0.32930952167134 0.405686461936686 no 2045 0.370960873940431 2928 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2297 7971671 152.32 µM -0.329483666711072 0.405621049017716 no 2046 0.370895068736572 3163 909016
SGTC_116 0155-0182 31.788 µM -0.330538543688338 0.405224869137947 no 2047 0.370496536977903 3004 771486
SGTC_2952 9073731 13.78 µM -0.330930147191553 0.405077819400972 no 2048 0.370348624798683 3017 16457353
SGTC_954 1189-0853 2.85 µM -0.332713191325043 0.404408444107914 no 2049 0.369675395549907 2977 2828194
SGTC_1540 guanosine 70.6 µM -0.332815787244511 0.404369936910664 no 2050 0.369636670234757 2976 6802 Guanosine is a purine nucleoside
SGTC_2881 9058953 51.95 µM -0.333816603362335 0.403994350507864 no 2051 0.369258976874318 2953 17122249
SGTC_2337 9009472 200 µM -0.334695806336487 0.403664476101548 no 2052 0.368927282621678 3195 5742383
SGTC_913 3487-1245 167 µM -0.335321197788915 0.403429872729261 no 2053 0.368691402461154 2936 4016153
SGTC_1148 3909-7663 27.7 µM -0.33534724738783 0.403420101484934 no 2054 0.368681578353617 3123 4084526
SGTC_1767 st044992 70.3 µM -0.335670613873624 0.403298811243735 no 2055 0.368559634020751 3039 9600693
SGTC_2198 6589944 200 µM -0.336896007710418 0.402839267679645 no 2056 0.368097647483976 3047 5290268
SGTC_3255 9139072 49.47 µM -0.338592532624776 0.402203263551235 no 2057 0.367458354384147 3083 17646060
SGTC_1964 st076914 61 µM -0.339869335117998 0.401724778252913 no 2058 0.366977465240554 2982 24208661
SGTC_1953 st076800 12.1 µM -0.344976953854467 0.399812163747055 no 2059 0.365055848282574 3035 297591
SGTC_1114 scopoletin 1.73284 µM -0.347696315979296 0.398794839663023 no 2060 0.364034131836597 3155 5280460 A coumarin with genotoxic properties.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.348885418488555 0.398350207261032 no 2061 0.363587666279052 3125 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_869 0564-0080 44.1 µM -0.350614225924482 0.397704002437244 no 2062 0.362938891262549 3055 6843321
SGTC_34 0469-0683 81.75 µM -0.354238800331821 0.396350098323932 no 2063 0.361579963960061 3094 3690923
SGTC_2552 juarezic acid 87.02 µM -0.35439663183431 0.396291171050921 no 2064 0.361520829196468 2997 1549512
SGTC_1605 st000082 49.1 µM -0.354992455747013 0.396068738229975 no 2065 0.361297621543124 3146 1114022
SGTC_2719 novobiocin 32.65 µM -0.355768546190852 0.395779059103108 no 2066 0.361006953212641 3155 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_211 3455-0679 143.504 µM -0.356159825292826 0.395633034293789 no 2067 0.360860438283071 3113 748649
SGTC_440 fluspirilene 35.1 µM -0.357596748427163 0.395096902434132 no 2068 0.360322556000719 3245 3396 An atypical antipsychotic.
SGTC_1283 0922-0125 16.4 µM -0.359338567780983 0.394447276710429 no 2069 0.359670912732696 3129 3360884
SGTC_1863 st057641 20.1 µM -0.359962315552258 0.3942147161604 no 2070 0.359437657492254 3106 3921635
SGTC_1440 4100-1550 40 µM -0.361833447974461 0.393517302394056 no 2071 0.358738247718288 3081 742806
SGTC_661 1304-0007 33.6 µM -0.364675190682398 0.392458773798797 no 2072 0.357676940027858 3064 3117130
SGTC_2099 5377090 177.372 µM -0.365089760463318 0.392304415828964 no 2073 0.357522202059425 3136 2243829
SGTC_877 0771-0151 33.1 µM -0.365764995520777 0.392053039882205 no 2074 0.357270221048911 3127 6166523
SGTC_3032 9089427 49.47 µM -0.366637321113595 0.391728357937423 no 2075 0.356944782863956 3142 17173707
SGTC_2166 5933061 31.504 µM -0.366913999806097 0.391625393118856 no 2076 0.35684158417495 3499 2877375
SGTC_1833 st055984 71 µM -0.368059638067324 0.39119912950362 no 2077 0.356414382874181 3079 676288
SGTC_94 0334-0113 514.748 µM -0.370749222545122 0.390198915993069 no 2078 0.35541216230996 3077 6795178
SGTC_1048 3161-0300 24.5 µM -0.371111575518739 0.390064218090259 no 2079 0.355277214841038 3090 2165101
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.371163842359837 0.390044789963969 no 2080 0.355257751124855 3216 688798
SGTC_1468 k284-1086 134 µM -0.373586320144317 0.389144632007235 no 2081 0.354356056572603 3091 15996457
SGTC_889 0919-1524 82.7 µM -0.374370466733613 0.38885338155578 no 2082 0.354064356097856 3124 3905452
SGTC_1344 1488-0097 29.1 µM -0.376260086544835 0.388151789283338 no 2083 0.353361774540555 3171 747966
SGTC_420 mitomycin C 81.9 mM -0.376840445280478 0.387936382454782 no 2084 0.353146090874456 3062 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.377865732155548 0.387555919718497 no 2085 0.352765170073131 3172 140250 A respiratory chain inhibitor.
SGTC_2051 5263410 176 µM -0.378154598508959 0.387448746870513 no 2086 0.352657875319132 3174 227584
SGTC_2021 4019055 173 µM -0.378221691382117 0.387423855844764 no 2087 0.352632956428986 3228 44827708 YER133W GLC7
SGTC_1372 2752-0194 270 µM -0.378361851273015 0.387371858917187 no 2088 0.352580901838615 3081 823334
SGTC_520 3584-0023 682 µM -0.378437889637924 0.387343650826788 no 2089 0.352552662775113 3098 1340790
SGTC_44 0929-0055 61.211 µM -0.378571077758593 0.387294243221082 no 2090 0.352503201442052 3036 1379590
SGTC_1053 3366-3204 134 µM -0.378998916233011 0.387135544164466 no 2091 0.352344334318576 3105 3632071 YPR165W RHO1
SGTC_1081 sertraline 6 µM -0.379654872636567 0.38689226546739 no 2092 0.352100811333223 3176 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3309 9129340 25.759 µM -0.382208082659561 0.38594576420139 no 2093 0.351153513525831 3110 17158987
SGTC_2916 7875993 68.79 µM -0.383408238703872 0.385501088075262 no 2094 0.350708547810108 3218 1299250
SGTC_3233 9132340 49.47 µM -0.385416756943053 0.384757238296562 no 2095 0.349964334743221 3078 17682950
SGTC_2260 7964312 200 µM -0.385875254812472 0.384587494086348 no 2096 0.349794528900409 3233 231951
SGTC_2849 9019321 12.99 µM -0.386485888522217 0.384361460793067 no 2097 0.349568425815553 3187 16489627
SGTC_171 k064-0041 9.68 µM -0.386690055382888 0.384285894780006 no 2098 0.349492839599497 3088 53325
SGTC_3049 9092223 49.47 µM -0.387457916282053 0.384001734345857 no 2099 0.349208617234675 3168 8623917
SGTC_2211 7117706 200 µM -0.387488608234603 0.383990377543769 no 2100 0.349197258418584 3172 822771
SGTC_1126 isoteolin 1.0172 µM -0.388832607523638 0.383493161488885 no 2101 0.348699988951624 3072 133323
SGTC_1507 4075-3230 155 µM -0.389599543527359 0.383209517407414 no 2102 0.348416344866726 3154 659771
SGTC_1210 3013-0140 750 nM -0.390719340631098 0.382795483422241 no 2103 0.348002350644446 3205 905973
SGTC_1060 3448-7350 82 µM -0.391582848417465 0.38247630130556 no 2104 0.347683231423649 3203 570178
SGTC_2773 thioridazine 9.09 µM -0.391818239740349 0.382389306429857 no 2105 0.347596258561584 3136 5452 An antipsychotic.
SGTC_620 0109-0052 432 µM -0.396095249339303 0.380809666112946 no 2106 0.346017381398436 3249 493037
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.396233911847226 0.380758486563128 no 2107 0.34596623811059 3126 688664
SGTC_1245 0418-0076 17.2 µM -0.396303589301587 0.380732769795189 no 2108 0.345940539837265 3253 6790114
SGTC_735 3076-0345 636 µM -0.397802560660617 0.380179652643011 no 2109 0.345387864792145 3259 2888990
SGTC_2356 9061756 188.97 µM -0.398221288794215 0.380025186598879 no 2110 0.345233537352285 3159 20104043
SGTC_1790 st045711 43.5 µM -0.398520012474347 0.379915001099445 no 2111 0.34512345476524 3266 585119
SGTC_2531 methyl deoxycholate 70.07 µM -0.398596212642878 0.379886895903347 no 2112 0.345095376357969 3067 16667744 Haematoxylin.
SGTC_2368 9071271 200 µM -0.399070852470197 0.379711846990458 no 2113 0.344920499226106 3127 27209959
SGTC_636 0kpi-0074 126 µM -0.39932364422756 0.379618626518345 no 2114 0.344827373702492 3159 616434
SGTC_1097 itavastatin 7.23 µM -0.399961016016976 0.379383617887677 no 2115 0.344592615138506 3134 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2868 9035608 32.47 µM -0.401291166098288 0.378893315033244 no 2116 0.344102883369794 3064 6462614
SGTC_1561 5-methoxyflavone 52.9 µM -0.401392151466804 0.378856099049453 no 2117 0.344065713460534 3152 94525
SGTC_3160 9100216 49.47 µM -0.402601638557883 0.378410455989449 no 2118 0.343620652029037 3162 17191039
SGTC_3343 9148379 18.9835 µM -0.4036407769292 0.378027708069407 no 2119 0.343238447747276 3260 1955036
SGTC_155 k072-0202 43.6 µM -0.404196469698467 0.377823077728742 no 2120 0.343034124783617 3203 5857737
SGTC_1261 0712-0010 12.7 µM -0.406338863800326 0.377034475993728 no 2121 0.342246816739106 3297 2840123
SGTC_3098 9119039 49.47 µM -0.406719223405899 0.376894521518377 no 2122 0.342107109977527 3173 17161528
SGTC_3187 9109394 49.47 µM -0.407428501739701 0.376633583609635 no 2123 0.341846648516908 3147 17098090
SGTC_1376 2910-0861 41.3 µM -0.408767858901249 0.37614099843514 no 2124 0.341355014589406 3159 1112859
SGTC_300 r073-0011 5.04 µM -0.409712102979433 0.375793848062502 no 2125 0.341008575351043 3237 2735780
SGTC_2442 5158906 48.48 µM -0.409787605408592 0.375766094007545 no 2126 0.340980879605106 3245 1893835
SGTC_1203 3992-3522 103 µM -0.410096014809048 0.375652731994377 no 2127 0.340867757994254 3418 5322312
SGTC_1792 st045773 43.6 µM -0.412482385559636 0.374775937463321 no 2128 0.339992944387359 3100 2919270
SGTC_825 1988-2224 89.6 µM -0.412852633844081 0.374639959598483 no 2129 0.339857293030065 3125 1180859
SGTC_1025 k007-0731 70 µM -0.413710677766875 0.374324893217693 no 2130 0.3395430031113 3098 6256118
SGTC_1070 indatraline 8.81 µM -0.414300118508396 0.374108504231212 no 2131 0.33932716353885 3156 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.414984544999521 0.373857294888733 no 2132 0.33907660851128 3151 5355888
SGTC_3067 9117431 49.47 µM -0.415644604803522 0.37361507974649 no 2133 0.338835041045195 3149 17150885
SGTC_2221 6807166 181.081 µM -0.416191301955416 0.373414501880268 no 2134 0.33863501200024 3184 674925
SGTC_3206 9114350 49.47 µM -0.417137553224483 0.373067412565633 no 2135 0.338288899122097 3223 17087243
SGTC_355 1311-2252 105 µM -0.417152085856976 0.373062082731591 no 2136 0.338283584546258 3155 5338538
SGTC_2217 6934799 96.0675 µM -0.41726626682421 0.373020207777314 no 2137 0.338241829749397 3221 675606
SGTC_3246 9135460 32.98 µM -0.420275792689784 0.371917030538169 no 2138 0.337141995908659 3217 41446951
SGTC_1623 st003709 20.3 µM -0.420982230851544 0.371658229220343 no 2139 0.336884028633188 3130 16192618
SGTC_2158 5657123 3.6195 µM -0.424724424115022 0.37028825877369 no 2140 0.335518788420737 3212 2858827
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.425336714074973 0.370064263045365 no 2141 0.33529561661085 3160 3256 An antibiotic and ribosome inhibitor.
SGTC_486 niguldipine 82 µM -0.426190282792133 0.369752073190902 no 2142 0.334984598789214 3138 1236 A calcium channel blocker.
SGTC_1189 1431-2119 7.28 µM -0.426278231790414 0.369719911017994 no 2143 0.334952558930037 3233 3107275
SGTC_3097 9117246 49.47 µM -0.427634824443598 0.369223932626844 no 2144 0.33445850390459 3210 16423892
SGTC_2618 avocadyne 43.43 µM -0.428930760937015 0.368750333706204 no 2145 0.333986806726374 3148 3015189
SGTC_1443 4112-3303 14 µM -0.429078052936319 0.368696518563871 no 2146 0.333933211710206 3167 704433
SGTC_1369 1866-0067 208 µM -0.42982396831678 0.368424027754537 no 2147 0.333661848135618 3302 3531355
SGTC_3077 9117319 49.47 µM -0.431560910418363 0.367789760974479 no 2148 0.333030286961009 3221 17154678
SGTC_403 arphamenine a 50 µM -0.431707547590866 0.367736230994114 no 2149 0.332976990563833 3190 5487158 An arginine aminopeptidase inhibitor.
SGTC_1940 st075990 51.1 µM -0.432101373173346 0.367592477467025 no 2150 0.332833868357176 3403 1084979
SGTC_2245 6637752 200 µM -0.433829980854546 0.366961723749184 no 2151 0.332205954314864 3247 681890
SGTC_3207 9114163 49.47 µM -0.433853927696143 0.366952988274648 no 2152 0.332197258964113 3394 849233
SGTC_2115 tiliquinol 12.7705 µM -0.435197247375986 0.366463074393011 no 2153 0.331709630210753 3212 71208 A bioactive hydroxyquinoline.
SGTC_1803 st050068 52.4 µM -0.435386933057476 0.366393912799888 no 2154 0.33164079673051 3285 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1032 k061-1018 98.7 µM -0.436228608020177 0.366087080745158 no 2155 0.33133543681061 3347 4005393
SGTC_1999 st074831 12.5 µM -0.436382405355465 0.366031023273274 no 2156 0.331279651200684 3168 17112523
SGTC_1145 3546-0597 10.2 µM -0.436644777901879 0.365935397907512 no 2157 0.331184491662413 3209 875334
SGTC_2181 6316240 54.2555 µM -0.438264750735508 0.365345160670917 no 2158 0.330597187587034 3245 12779990
SGTC_715 0868-0130 184 µM -0.439107730592092 0.365038146900056 no 2159 0.330291738931709 3314 2876258
SGTC_914 3820-6779 408 µM -0.439976999439139 0.364721649246368 no 2160 0.329976883008143 3128 2893481
SGTC_1799 st045822 46.1415 µM -0.440408867314375 0.364564441968246 no 2161 0.329820501865683 3301 3674992
SGTC_777 1315-0167 517 µM -0.440661022592958 0.364472663671815 no 2162 0.329729209147408 3236 4221767
SGTC_3026 9090633 49.47 µM -0.441149762935598 0.36429479637858 no 2163 0.329552289788761 3160 25236842
SGTC_2651 TUB2.036 5 µM -0.44125740767981 0.364255625147773 no 2164 0.32951332853869 3339 15992207 YFL037W TUB2
SGTC_2721 ifenprodil 61.44 µM -0.443437866226801 0.36346247604954 no 2165 0.328724525963624 3318 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1859 st055998 20 µM -0.444956574592847 0.362910386160761 no 2166 0.328175568313912 3347 676301
SGTC_2924 9010168 62.78 µM -0.445283418857108 0.362791606995449 no 2167 0.32805747449798 3265 2993929
SGTC_1910 st062352 60.4 µM -0.445713547461797 0.362635313168005 no 2168 0.327902088667005 3134 2245730
SGTC_1434 4073-0095 163 µM -0.446152081158464 0.362475988782155 no 2169 0.327743697125699 3285 24133745
SGTC_2399 5884133 200 µM -0.446681606515863 0.362283637809389 no 2170 0.327552482113842 3190 722445
SGTC_65 0798-0905 34.986 µM -0.448768598563229 0.361525873400943 no 2171 0.326799296622066 3518 3602145
SGTC_2406 ethylparaben 405.7 µM -0.450390628597733 0.360937306402416 no 2172 0.326214400526924 3062 8434 A possible steroid mimic.
SGTC_947 3447-0010 211 µM -0.452473505145595 0.360182000273657 no 2173 0.325463952017495 3273 748350
SGTC_469 w7 172 µM -0.453252388456146 0.359899696542701 no 2174 0.325183506278282 3276 45115570 A P450 inhibitor.
SGTC_2732 terfenadine 20 µM -0.453399682765426 0.359846318784044 no 2175 0.32513048242321 3246 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2333 9017922 200 µM -0.454148937155368 0.359574839970455 no 2176 0.324860816343625 3307 3163164
SGTC_1948 st076329 66.6 µM -0.455536388629559 0.359072309123102 no 2177 0.324361697440272 3238 24208413
SGTC_1782 st039423 80.636 µM -0.455665741372681 0.35902547034878 no 2178 0.324315180413328 3210 2068169
SGTC_1539 benzyladenosine 56 µM -0.455883246171684 0.358946716393478 no 2179 0.324236968875023 3197 92208 A nucleotide analog.
SGTC_2120 5538279 151.968 µM -0.455910807355265 0.358936737491119 no 2180 0.324227058830827 3241 2058197
SGTC_2862 9027634 71.43 µM -0.457579906087603 0.358332597202934 no 2181 0.323627141242505 3163 5012562
SGTC_806 3966-4455 5.86 µM -0.458887789537025 0.357859448551403 no 2182 0.323157373831062 3207 714982
SGTC_3045 9092950 49.47 µM -0.459256492354101 0.357726103569962 no 2183 0.323024993537427 3354 44120432
SGTC_3286 9117135 37.221 µM -0.459295533538153 0.357711984960017 no 2184 0.323010977372111 3193 3438150
SGTC_1521 st012942 49.4 µM -0.460053905766937 0.357437770605692 no 2185 0.322738764233832 3363 24207259
SGTC_2864 9034755 47.6 µM -0.460490590726023 0.357279906212989 no 2186 0.322582061874288 3314 4930451
SGTC_1909 st060837 51.5 µM -0.460616355982662 0.357234445800886 no 2187 0.322536937441709 3218 678937
SGTC_1638 st008370 60.6 µM -0.46212214869288 0.356690303914651 no 2188 0.321996863880254 3281 24207134
SGTC_3109 9122853 49.47 µM -0.462167413617893 0.356673951229715 no 2189 0.321980634795013 3260 1234709
SGTC_2569 tetrandrine 100 µM -0.46235616330968 0.356605765196093 no 2190 0.321912964978395 3207 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_550 4123-0385 25.7 µM -0.463454674600947 0.356209017790033 no 2191 0.321519248172374 3226 5731123
SGTC_193 1273-0060 1.558 µM -0.463681975468353 0.356126943349216 no 2192 0.321437806408096 3277 2847393 YHR072W ERG7
SGTC_3091 9116372 49.47 µM -0.464299614457709 0.35590395818801 no 2193 0.321216550087185 3354 17169793
SGTC_257 daunorubicin 18.5 µM -0.464516957180273 0.355825503031317 no 2194 0.321138706664196 3326 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1829 berberine 14.4 µM -0.465346828354946 0.355525996982177 no 2195 0.320841552495883 3345 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1476 4112-3294 3.34 µM -0.466270953452623 0.355192579024626 no 2196 0.320510783601551 3336 704369
SGTC_3192 9110362 49.47 µM -0.466744095062748 0.355021915678406 no 2197 0.32034148880472 3331 16649480
SGTC_148 3253-0744 288.01 µM -0.467316717549959 0.354815408233652 no 2198 0.320136648756927 3315 6893655
SGTC_2054 5233173 129 µM -0.467780794529125 0.354648077335423 no 2199 0.31997067810419 3330 6889
SGTC_1565 sinapyl alcohol 95.1 µM -0.467914690362396 0.354599804112347 no 2200 0.319922798824086 3294 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1504 k297-0033 30 µM -0.468831088387545 0.354269479504876 no 2201 0.319595188242003 3147 4388117
SGTC_3191 9110352 49.47 µM -0.469090522709494 0.354175983770172 no 2202 0.319502466505994 3290 17122424
SGTC_515 4092-1064 102 µM -0.471812197617427 0.353195668993301 no 2203 0.318530421865272 3415 717353
SGTC_719 2810-4230 27.3 µM -0.47248045322993 0.35295511989538 no 2204 0.318291945280173 3278 721079
SGTC_824 1304-0008 100 µM -0.473238295795387 0.352682393672962 no 2205 0.318021589412125 3237 768245
SGTC_3121 9125696 49.47 µM -0.473650984904041 0.352533910295906 no 2206 0.317874405767021 3272 1235365
SGTC_311 1315-0136 58 µM -0.474010732859665 0.352404493195784 no 2207 0.317746126804884 3391 6759207
SGTC_1228 0124-0032 52.5 µM -0.474103208096214 0.352371228561815 no 2208 0.317713155509154 3325 X1228
SGTC_37 0566-0070 1.56 µM -0.478421213844156 0.350819242837405 no 2209 0.316175218855766 3289 1626686
SGTC_1108 betulinic acid 729.144 nM -0.478700550196272 0.350718928579171 no 2210 0.316075837172447 3274 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_59 0330-0160 1.33 µM -0.479057177998705 0.350590872820743 no 2211 0.315948976217064 3341 4293482
SGTC_3173 9105693 49.47 µM -0.479170520034728 0.350550178200932 no 2212 0.315908662308275 3407 17096658
SGTC_3120 9124077 49.47 µM -0.480088218648071 0.350220748497799 no 2213 0.31558233258131 3313 18774327 YGL155W CDC43
SGTC_2080 5212524 12.4 µM -0.483066521721031 0.349152393144167 no 2214 0.314524251993064 3348 260183
SGTC_2763 lisinopril 49.32 µM -0.483317072891343 0.349062571588307 no 2215 0.314435309725458 3364 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1956 st077085 54 µM -0.483961915791466 0.348831436978232 no 2216 0.314206448779849 3274 24208685
SGTC_1901 st060216 58.6 µM -0.48463437096668 0.348590464888052 no 2217 0.313967864037314 3229 688792
SGTC_632 0781-2353 4.65 µM -0.485426612849515 0.348306646001137 no 2218 0.313686879143122 3333 6811515 YHR007C ERG11
SGTC_2949 9072542 2.23 µM -0.485555194386023 0.348260589958447 no 2219 0.313641285240827 3328 16457352
SGTC_1437 4092-1038 11.6 µM -0.486429005510481 0.347947662779145 no 2220 0.313331514793882 3256 3977136
SGTC_1010 4112-3296 15.2 µM -0.486853004092157 0.347795858698521 no 2221 0.313181252583469 3396 704384
SGTC_643 k048-0106 28.4 µM -0.487213880899934 0.347666673304619 no 2222 0.313053384731645 3338 6763920
SGTC_761 k216-0224 480 µM -0.488284036041421 0.347283687019314 no 2223 0.312674333710607 3421 1340404
SGTC_2600 tangeritin 87.95 µM -0.489895164272949 0.346707391807306 no 2224 0.312104042547143 3271 68077 A bioactive flavone.
SGTC_2871 9038510 12.99 µM -0.49053894399932 0.346477212997623 no 2225 0.311876289548737 3415 4945164
SGTC_2272 7805186 180 µM -0.49166269074044 0.34607556128887 no 2226 0.311478908712446 3369 2956062 YPR165W RHO1
SGTC_541 4513-1321 94 µM -0.492612904593875 0.345736069079981 no 2227 0.311143064062908 3279 747515
SGTC_1671 st016596 74.5 µM -0.492811906581479 0.345664985387025 no 2228 0.311072748474119 3363 2829167
SGTC_1383 3049-0032 20.7 µM -0.49404675293551 0.345224018852014 no 2229 0.310636580688542 3386 712864
SGTC_3296 9122258 64.045 µM -0.494286412914452 0.345138460031126 no 2230 0.310551959700323 3340 4730474
SGTC_1922 5578187 25 µM -0.495078044200022 0.344855903248276 no 2231 0.310272515696523 3443 1350412
SGTC_3156 9099931 49.47 µM -0.496088566234387 0.344495343541737 no 2232 0.309915962884034 3223 18111053
SGTC_445 e6 berbamine 66 µM -0.498911727758142 0.343488773717193 no 2233 0.308920785832627 3359 6610268 A calcium/calmodulin antagonist.
SGTC_1330 1469-0054 61.8 µM -0.501263350309566 0.342651172506851 no 2234 0.308092897453936 3380 7102664
SGTC_2734 clemastine 41.6 µM -0.502742280087294 0.342124802778973 no 2235 0.307572739789002 3302 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2729 fluphenazine 10.66 µM -0.503614764580889 0.341814418297584 no 2236 0.307266057595225 3256 3372 An atypical antipsychotic.
SGTC_819 1013-0258 27.7 µM -0.504692317476496 0.341431228724279 no 2237 0.306887478907044 3314 5753198
SGTC_8 0354-0001 70 µM -0.505369500029555 0.341190498801018 no 2238 0.306649668385235 3353 4993152
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.506317495302624 0.340853606910358 no 2239 0.30631689153934 3428 1273210
SGTC_144 4161-2749 112.381 µM -0.506775376020491 0.34069093390542 no 2240 0.306156217851702 3305 797501 YMR168C CEP3
SGTC_745 0469-0705 296 µM -0.506832203154556 0.340670746781656 no 2241 0.306136279395285 3505 3486736
SGTC_1040 k898-0338 155 µM -0.507283427186821 0.340510471328364 no 2242 0.305977982618017 3437 20969351
SGTC_1408 3909-7976 48.8 µM -0.508839774378431 0.339957875592441 no 2243 0.305432268684297 3341 24152374
SGTC_2895 9054447 58.44 µM -0.509490852067592 0.339726806212099 no 2244 0.305204104433256 3317 2697450
SGTC_1526 st051518 75 µM -0.50970636711367 0.339650332551686 no 2245 0.305128595813371 3280 673993
SGTC_1016 4226-1401 38 µM -0.509833412357638 0.33960525473178 no 2246 0.305084087674394 3373 2901613
SGTC_2885 9057732 51.95 µM -0.510439809734606 0.339390126217294 no 2247 0.304871686401293 3425 6471414
SGTC_1074 carmofur 3.8 µM -0.510923466834891 0.339218579158123 no 2248 0.304702324174182 3382 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1364 1653-0028 37.6 µM -0.51129280754387 0.33908760111461 no 2249 0.304573020300107 3350 5718652
SGTC_3344 9148862 3.898 µM -0.51328212403595 0.338382471323719 no 2250 0.303876993261065 3433 4905352
SGTC_554 4483-2211 187 µM -0.516413545557417 0.337273661007623 no 2251 0.30278280356943 3351 747107
SGTC_985 1493-0307 8.71 µM -0.516915396807849 0.337096090674176 no 2252 0.30260760953408 3436 3278274
SGTC_1761 st044296 37 µM -0.517811387733599 0.336779151915085 no 2253 0.302294936105129 3310 1826700
SGTC_3113 9123498 49.47 µM -0.519096269448204 0.336324853140002 no 2254 0.301846804848743 3407 8897275
SGTC_1134 3477-0009 42.5 µM -0.519305845320206 0.336250775528184 no 2255 0.301773738900948 3486 3973534
SGTC_3247 9135149 49.47 µM -0.520434431138471 0.335851969968743 no 2256 0.301380408651869 3342 8934436 YOR116C RPO31
SGTC_731 3966-0296 387 µM -0.520853902506898 0.3357037894904 no 2257 0.301234275009876 3359 660956
SGTC_710 3448-4187 58 µM -0.521388369130089 0.335515023338804 no 2258 0.301048126066776 3409 3946412
SGTC_2277 7947813 106.88 µM -0.522723566190812 0.33504363183567 no 2259 0.30058331809004 3480 1246798
SGTC_378 3970-0959 8.33 µM -0.523200147988587 0.334875437424659 no 2260 0.300417489232137 3407 6615653
SGTC_1853 st056710 91.2 µM -0.523376527153567 0.334813198393813 no 2261 0.300356127760037 3455 269167
SGTC_1140 3229-1848 2.98 µM -0.524017007345676 0.334587229894781 no 2262 0.300133355387861 3406 2849525
SGTC_1348 1493-0373 93.8 µM -0.524260125060181 0.334501470955096 no 2263 0.300048813544914 3346 3010129
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.524330417810157 0.334476677037726 no 2264 0.300024371926194 3354 4620898
SGTC_3130 9127414 49.47 µM -0.525915230552556 0.333917867856978 no 2265 0.299473553105232 3392 1494646
SGTC_1496 4469-0713 57.4 µM -0.527991627233963 0.333186282029476 no 2266 0.298752573619302 3426 746691
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.530425469971466 0.332329563204345 no 2267 0.297908485322757 3427 5024745
SGTC_1643 st009866 20.2 µM -0.531489678940307 0.331955233724111 no 2268 0.297539745794288 3394 3156273 YOR207C RET1
SGTC_1155 4088-0394 48.2 µM -0.533919326671699 0.331101247720905 no 2269 0.296698675024255 3314 2326248
SGTC_1865 st057639 52.2 µM -0.535137602400423 0.330673371585532 no 2270 0.296277354921508 3387 688818
SGTC_2963 9082507 9 µM -0.5401691475481 0.328908568002063 no 2271 0.294540193760109 3434 16459611
SGTC_255 tunicamycin 200.472 nM -0.541369598758796 0.328488073440447 no 2272 0.294126428652099 3379 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1422 4031-0024 15.5 µM -0.541953718047497 0.328283546382558 no 2273 0.293925194733786 3388 782427
SGTC_3087 9117406 49.47 µM -0.542658203840493 0.328036941928646 no 2274 0.293682578298752 3428 42546093
SGTC_488 nitrendipine 139 µM -0.543175099792284 0.327856050745824 no 2275 0.293504624525808 3424 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2286 7945697 125 µM -0.543264429073198 0.327824793459935 no 2276 0.293473875849752 3377 1245733
SGTC_3154 9100113 49.47 µM -0.545192127042544 0.327150565179175 no 2277 0.292810692858839 3344 25237525
SGTC_1092 toremifene 6.32 µM -0.54559828748958 0.327008579029407 no 2278 0.292671050892003 3424 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2426 5582046 32.21 µM -0.546797039523993 0.326589663641784 no 2279 0.292259088606844 3477 2251934
SGTC_1154 4088-0362 150 µM -0.547300636123529 0.326413742148594 no 2280 0.292086103449738 3427 6618304
SGTC_693 4161-2696 114 µM -0.547717146138936 0.326268271793824 no 2281 0.291943068503926 3413 805759
SGTC_1015 4130-4525 82 µM -0.548888206984313 0.325859408554018 no 2282 0.29154108589082 3335 1363237
SGTC_336 4111-0029 111 µM -0.549441326637385 0.325666365559204 no 2283 0.29135130981358 3381 3131175
SGTC_2912 7964298 10.93 µM -0.550287986557042 0.325370965308664 no 2284 0.291060931390915 3434 2975850
SGTC_878 0828-0289 13.7 µM -0.55098482652063 0.325127919620128 no 2285 0.290822038092161 3433 745350 YLR208W SEC13
SGTC_663 1486-0733 13.9 µM -0.551588395484973 0.324917465348162 no 2286 0.290615194420109 3372 722445 YPR165W RHO1
SGTC_2384 9036245 200 µM -0.552700049888587 0.324529996517825 no 2287 0.290234409596533 3373 6462766
SGTC_698 k064-0052 127 µM -0.552865423285605 0.324472371582099 no 2288 0.290177782759892 3482 5088751
SGTC_2919 7978188 46.38 µM -0.553442525710885 0.32427131116293 no 2289 0.289980213034568 3488 2980291
SGTC_2727 riluzole 51.77 µM -0.553766538637413 0.324158448670959 no 2290 0.289869315586118 3442 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2581 avocatin a 64 µM -0.554523572698113 0.323894816161264 no 2291 0.289610288839378 3362 6710728 A skin care supplement.
SGTC_2807 7945238 51.95 µM -0.555774249437739 0.323459469109174 no 2292 0.28918259554342 3441 17148797
SGTC_1570 verbenone 133 µM -0.556647632634167 0.323155597062558 no 2293 0.28888410133183 3491 29025 A natural terpanoid with antifungal properties.
SGTC_1483 3453-0561 55.9 µM -0.556758347693354 0.323117084921477 no 2294 0.288846272853146 3449 4546991
SGTC_400 oxethazaine 37.5 µM -0.556934220316878 0.323055911674039 no 2295 0.288786186510197 3426 4621 A local anesthetic.
SGTC_23 0213-0011 39.996 µM -0.558797236016153 0.32240819862851 no 2296 0.288150054516353 3495 627608
SGTC_796 1234-0020 70.7 µM -0.559722741870666 0.322086628975654 no 2297 0.287834283906299 3438 46495034
SGTC_830 4076-0286 57.8 µM -0.560183708941883 0.321926514307724 no 2298 0.287677068911091 3479 6866659
SGTC_2083 5306046 65.942 µM -0.562375191668877 0.321165765978357 no 2299 0.28693020898142 3432 539837
SGTC_157 1348-1695 65.819 µM -0.563254083120126 0.320860879283432 no 2300 0.286630940025963 3472 5380510
SGTC_1156 4092-0367 4.88 µM -0.565068709487185 0.32023176920556 no 2301 0.286013515275265 3416 1357585
SGTC_3200 9114385 49.47 µM -0.56522828626791 0.320176470448864 no 2302 0.285959249689628 3482 17018030 YLR208W SEC13
SGTC_743 1275-0778 158 µM -0.569367062432698 0.318743642477183 no 2303 0.284553532273583 3456 2849257 YMR203W TOM40
SGTC_2397 5161689 200 µM -0.569389526005231 0.318735873040244 no 2304 0.284545911631382 3539 2259942
SGTC_2821 7996764 71.43 µM -0.569585310834881 0.318668160653891 no 2305 0.284479496842611 3566 2987135
SGTC_1429 4049-0205 9.46 µM -0.570779823052586 0.318255168585226 no 2306 0.284074450882727 3497 22774478
SGTC_248 streptozotocin 5.23457 mM -0.570782509262036 0.318254240106281 no 2307 0.284073540329598 3474 5300 DNA alkylating agent.
SGTC_327 1273-0057 3.96 µM -0.574805238996912 0.316865081555339 no 2308 0.282711511583441 3440 3108138
SGTC_1927 st060202 13.8 µM -0.575173923550982 0.31673789337384 no 2309 0.282586838327171 3502 688887
SGTC_2846 9008642 19.48 µM -0.575200296763817 0.316728796016908 no 2310 0.282577921054097 3470 2992898
SGTC_890 0929-0006 47.2 µM -0.576746425501732 0.316195657637732 no 2311 0.282055382775744 3391 1378169
SGTC_1310 1188-0297 994 nM -0.57681048935926 0.316173575277102 no 2312 0.282033741440991 3453 1588352
SGTC_2822 7994718 71.43 µM -0.577394695056419 0.315972233946532 no 2313 0.28183642852032 3454 1018011
SGTC_1085 doxorubicin 7.67 µM -0.578859469849688 0.315467652326112 no 2314 0.281341999931157 3506 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1172 0370-0043 85 µM -0.578999134589162 0.315419558942399 no 2315 0.281294878555654 3505 376585
SGTC_1683 st010134 710 nM -0.579380484725855 0.315288257412266 no 2316 0.281166234543749 3466 3818134
SGTC_1981 st071826 47 µM -0.579532512603426 0.315235919648763 no 2317 0.281114957638623 3447 11838600
SGTC_369 0957-0393 4.5 µM -0.580009265345332 0.315071814773808 no 2318 0.28095418481834 3441 6997992
SGTC_268 camptothecin 39.6153 µM -0.580653739013827 0.314850036053434 no 2319 0.280736923014654 3508 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2557 derrustone 83.84 µM -0.581402445139702 0.314592472287607 no 2320 0.280484624951048 3503 629853 An antioxidant.
SGTC_3337 9144342 33.5465 µM -0.584155779021131 0.31364606936397 no 2321 0.279557754978879 3472 17682949
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.585395565795189 0.313220317342511 no 2322 0.279140884813821 3611 16725076
SGTC_2642 cholecalciferol 100 µM -0.585628955540844 0.31314019737929 no 2323 0.279062442857149 3473 9821465 A vitamin D precursor, similar to steriods.
SGTC_2511 berberine 10.47 µM -0.589418218495799 0.311840624271887 no 2324 0.277790379056274 3486 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2484 5809818 12.04 µM -0.58975612827082 0.311724847441124 no 2325 0.277677079656741 3467 2870548
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.589832443622425 0.311698702357438 no 2326 0.277651494639006 3494 442882
SGTC_2193 5925765 200 µM -0.591707065436833 0.311056768855378 no 2327 0.277023382234124 3509 877370
SGTC_266 formosanin C 406 nM -0.592519961020783 0.310778584514123 no 2328 0.276751229097295 3457 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1493 4348-0038 111 µM -0.593347556221616 0.310495480830367 no 2329 0.276474289236329 3542 800424
SGTC_2824 7998404 51.95 µM -0.59385918440219 0.310320519229742 no 2330 0.276303150058565 3458 837851
SGTC_2733 amorolfine 100 µM -0.594170621450718 0.310214038044932 no 2331 0.27619900009289 3498 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2387 9077560 195.08 µM -0.594204815724736 0.310202347897587 no 2332 0.276187566106895 3416 5303272
SGTC_709 3807-1509 243 µM -0.594212629617759 0.310199676554421 no 2333 0.276184953306042 3540 1886677 YPL242C IQG1
SGTC_2210 7115885 190.385 µM -0.594557382139635 0.310081825646984 no 2334 0.276069687418213 3511 2927039
SGTC_25 0118-0223 35.662 µM -0.594570695883377 0.310077274840712 no 2335 0.276065236523504 3543 5333628
SGTC_3094 9117742 49.47 µM -0.596659755962842 0.309363568417019 no 2336 0.275367283274616 3482 17149698
SGTC_2922 7999257 32.47 µM -0.596848554554562 0.309299102638051 no 2337 0.275304248629388 3510 2988377
SGTC_2144 5628481 200 µM -0.597991779842292 0.308908870776306 no 2338 0.274922708989684 3488 2818399
SGTC_1176 0848-0131 83.3 µM -0.598388482847438 0.308773509376975 no 2339 0.274790374378428 3520 6769040
SGTC_3092 9117248 49.47 µM -0.60043468218278 0.308075726317645 no 2340 0.274108289843948 3534 17141857
SGTC_2013 4024628 200 µM -0.601582653732776 0.307684555058792 no 2341 0.2737259891268 3553 5230760
SGTC_2126 5251174 33.877 µM -0.602074356872436 0.307517074052669 no 2342 0.273562321477138 3577 790722
SGTC_1957 st077035 62.4 µM -0.602490309275512 0.307375426133648 no 2343 0.273423905940495 3575 705593
SGTC_1465 k213-0056 144 µM -0.604963470284107 0.306533812655664 no 2344 0.272601634468774 3448 24048857 YMR208W ERG12
SGTC_1355 1499-0035 1.68 µM -0.605705518512516 0.306281493200018 no 2345 0.272355159420057 3521 1548538
SGTC_2942 9052777 62.25 µM -0.605899016341476 0.306215713018207 no 2346 0.2722909063462 3586 6469503
SGTC_2280 7785178 200 µM -0.605915454687059 0.306210125039941 no 2347 0.27228544816059 3487 2954328
SGTC_450 aminopyrene 156 nM -0.606309906382145 0.306076050403513 no 2348 0.272154490789487 3513 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1893 st059353 36.1 µM -0.60709547113231 0.305809113324494 no 2349 0.271893777769957 3501 3112488
SGTC_688 0527-0193 473 µM -0.607370974389056 0.305715520975203 no 2350 0.271802373259926 3483 4007154
SGTC_2213 7173844 200 µM -0.60778877482649 0.305573612477979 no 2351 0.271663787587715 3500 892728
SGTC_2802 7925815 54.55 µM -0.607819481357876 0.305563183966779 no 2352 0.271653603526029 3496 1262923
SGTC_3014 9081533 49.47 µM -0.611095754522931 0.3044514080873 no 2353 0.270568095137758 3540 21367265
SGTC_724 3910-0327 137 µM -0.612353651195902 0.304025030198645 no 2354 0.270151900026636 3530 2885483
SGTC_837 0091-0265 12.5 µM -0.612416710141888 0.304003662684546 no 2355 0.270131044403608 3490 759367
SGTC_3074 9116018 49.47 µM -0.613255295216128 0.303719571938036 no 2356 0.269853773920917 3543 17027303
SGTC_475 α-linolenic acid 10 µM -0.614843054169289 0.30318200543785 no 2357 0.269329186523219 3639 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2867 9039098 71.43 µM -0.616945283461644 0.302470910456355 no 2358 0.268635408424187 3526 6463460
SGTC_2233 sulbentine 40.3845 µM -0.616990116010774 0.302455753653795 no 2359 0.268620622564254 3516 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2792 7535235 81.82 µM -0.617081539324354 0.30242484669389 no 2360 0.268590472249033 3477 1281891
SGTC_3291 9121177 71.43 µM -0.618257163910699 0.302027536247209 no 2361 0.268202916942398 3482 17015612
SGTC_93 0109-0045 59.227 µM -0.618698891910214 0.301878311830515 no 2362 0.268057370062517 3610 88733
SGTC_1715 st032160 10.2275 µM -0.620609926535931 0.30123310876459 no 2363 0.26742815340632 3493 5289825
SGTC_3050 9093513 49.47 µM -0.621767785688034 0.300842495050713 no 2364 0.267047285864491 3562 25236664
SGTC_287 k060-0039 29.6 µM -0.624547584497558 0.299905640144164 no 2365 0.266134015145056 3581 5861974
SGTC_571 k831-0106 44.2 µM -0.626076754225935 0.299390839108055 no 2366 0.265632299277391 3538 4783639
SGTC_3194 9111903 49.47 µM -0.62707738474526 0.299054189943799 no 2367 0.265304255315661 3585 17087251
SGTC_391 gliotoxin 8.33 µM -0.627670417078159 0.29885475305482 no 2368 0.265109934326719 3605 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_313 3474-0040 5.03 µM -0.628101837275615 0.298709704342072 no 2369 0.264968614793567 3539 1043375 YIL048W NEO1
SGTC_614 0462-0418 107 µM -0.628102291633118 0.29870955159843 no 2370 0.264968465980683 3453 5188303
SGTC_1658 st012944 20 µM -0.628319908488833 0.298636398329382 no 2371 0.264897196168488 3513 24207260
SGTC_1317 1273-0028 910 nM -0.628636976406656 0.298529828546945 no 2372 0.264793373442109 3536 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1447 4239-0816 81.9 µM -0.629873734007685 0.298114307064426 no 2373 0.26438859952846 3493 1341554
SGTC_2128 5255449 168.493 µM -0.63070854541459 0.297833979097117 no 2374 0.264115555289852 3551 736008
SGTC_1137 ixabepilone 100 µM -0.63174174169973 0.297487200453443 no 2375 0.26377782375144 3588 154225 A novel microtubule stabilizer.
SGTC_3243 9134147 49.47 µM -0.632516550488663 0.297227267183238 no 2376 0.263524698584327 3603 24282180
SGTC_306 1672-3436 11.6 µM -0.633649280060654 0.296847445381085 no 2377 0.263154866160176 3583 6797378
SGTC_1998 st075797 76.8 µM -0.634262068103481 0.296642060677257 no 2378 0.262954903497008 3570 24208315
SGTC_1636 st007707 68.9 µM -0.63666899253718 0.295835976018352 no 2379 0.262170237500039 3617 403051
SGTC_3298 9116858 71.43 µM -0.637389744806966 0.295594790284508 no 2380 0.261935503318538 3595 2506942
SGTC_1326 1431-2094 10.8 µM -0.637521911364762 0.29555057312536 no 2381 0.261892471086006 3556 616278
SGTC_1252 0493-0875 34.8 µM -0.639643567375918 0.294841176321257 no 2382 0.26120217570232 3570 3960963
SGTC_2062 5245942 200 µM -0.64085165070938 0.29443759265213 no 2383 0.260809535651388 3644 1376160
SGTC_3104 9120930 49.47 µM -0.641715728778721 0.294149087133999 no 2384 0.26052888737893 3588 17014836
SGTC_1919 st067113 52.3 µM -0.642143130673225 0.294006430964889 no 2385 0.260390126862832 3575 1268243
SGTC_874 0599-0792 117 µM -0.64388178533398 0.293426441073521 no 2386 0.259826047028329 3629 765305
SGTC_860 0443-0016 25.1 µM -0.646086248577451 0.292691827255688 no 2387 0.259111750280837 3601 5337942
SGTC_17 0960-0276 49.807 µM -0.646883927810525 0.292426219806837 no 2388 0.258853534261251 3600 6821114
SGTC_55 0767-0285 6.563 µM -0.648731595809812 0.291811422846096 no 2389 0.258255939111179 3571 3116166
SGTC_3063 1327-0034 4 µM -0.651150189620487 0.291007566112078 no 2390 0.257474770260672 3542 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3266 9136860 49.47 µM -0.652495501022687 0.29056087947937 no 2391 0.257040787112773 3530 4871271 YPR165W RHO1
SGTC_3294 9122953 26.2835 µM -0.653561709218401 0.290207092136729 no 2392 0.256697110151098 3605 16459826
SGTC_2325 6158266 200 µM -0.653567831593536 0.290205061203777 no 2393 0.256695137382122 3592 3623240
SGTC_3276 9139060 49.47 µM -0.653798627509828 0.290128505735759 no 2394 0.256620775429318 3652 4870619
SGTC_2972 9093619 59.92 µM -0.656081721338431 0.28937170929305 no 2395 0.255885772289374 3592 25236256
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.656101435342974 0.289365178565964 no 2396 0.255879430489241 3620 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2985 9022375 71.43 µM -0.656925656581279 0.289092197913568 no 2397 0.255614360097576 3650 4939335
SGTC_992 3909-8734 162 µM -0.657599244791454 0.2888691966329 no 2398 0.255397839982896 3601 4288319
SGTC_349 k015-0014 24 µM -0.660088207899812 0.288045891887042 no 2399 0.254598612772953 3590 2196908
SGTC_1993 st073995 70.8 µM -0.661216226726687 0.287673128368313 no 2400 0.254236828217776 3613 3098394
SGTC_577 r071-0003 38.6 µM -0.66140027603476 0.287612329331406 no 2401 0.254177824475831 3651 4568517 YMR134W ERG29
SGTC_627 1391-0720 175 µM -0.662273230517205 0.287324039408632 no 2402 0.253898064803865 3573 997839
SGTC_1268 0828-0275 2.46 µM -0.66330208001407 0.286984441376566 no 2403 0.253568552344008 3643 745337
SGTC_1229 0139-0193 12.2 µM -0.66342644941025 0.286943402967644 no 2404 0.253528735440586 3650 3090752
SGTC_2212 7123476 200 µM -0.664072136072509 0.286730389194733 no 2405 0.253322071450428 3577 1085715
SGTC_457 grayanotoxin iii 135 µM -0.664645214274232 0.286541391969104 no 2406 0.253138721354151 3583 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_133 0724-0033 378.92 µM -0.666735410639479 0.285852561007912 no 2407 0.252470577925135 3530 280309
SGTC_1883 5-benzylidenerhodanine 20 µM -0.6668030166274 0.285830294388132 no 2408 0.252448982803641 3608 1273210
SGTC_1505 k297-0037 20.6 µM -0.667833706026464 0.285490930057427 no 2409 0.252119874225399 3608 4089396
SGTC_605 1315-0399 119 µM -0.671189536910838 0.284387321735227 no 2410 0.251049896642636 3670 24020461
SGTC_3295 9122362 53.5725 µM -0.671728049548304 0.284210414889536 no 2411 0.250878420530532 3622 4730473
SGTC_2514 salinomycin 42.74 µM -0.671813595442232 0.28418231704232 no 2412 0.250851186251165 3675 23682228 A polyether potassium ionophore.
SGTC_3079 9117512 49.47 µM -0.672067173941358 0.284099036104984 no 2413 0.250770466526796 3650 7185044
SGTC_3059 1327-0034 3 µM -0.673937933600146 0.283484997158106 no 2414 0.250175387014735 3594 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2236 dapsone 200 µM -0.674490759476595 0.283303665099296 no 2415 0.249999679274407 3652 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.675468503963228 0.282983092016836 no 2416 0.249689077672463 3578 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1778 st046819 58.9 µM -0.676449040512985 0.282661778495615 no 2417 0.249377795055498 3674 671715
SGTC_2686 alizarin 95.37 µM -0.679317688637018 0.28172275494643 no 2418 0.248468295495337 3619 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_207 4185-0010 4.486 µM -0.68009604316206 0.281468227923902 no 2419 0.24822182486257 3696 3761753
SGTC_3349 9149703 23.001 µM -0.68043964375702 0.281355903591522 no 2420 0.248113063166269 3630 4910494
SGTC_2940 9060638 45.86 µM -0.680925537383952 0.281197100068648 no 2421 0.247959304112342 3636 4027022
SGTC_18 0111-0177 500 nM -0.681909171663923 0.280875753652985 no 2422 0.247648192789015 3730 721752
SGTC_941 3237-0776 460 µM -0.682240136149865 0.280767669807231 no 2423 0.24754355972262 3652 760008
SGTC_2326 6164455 177.58 µM -0.683391663592281 0.280391769609256 no 2424 0.24717969316095 3632 2888790
SGTC_1760 st045453 10.4495 µM -0.684085454143862 0.280165408979182 no 2425 0.246960603213651 3666 3323419 YIL048W NEO1
SGTC_1037 k284-1091 78.7 µM -0.684413503479505 0.280058408304209 no 2426 0.24685704573577 3626 3334711
SGTC_2125 5246583 200 µM -0.684697135463814 0.279965911317653 no 2427 0.246767528512973 3678 835267
SGTC_2671 danthron 100 µM -0.686837724736435 0.279268308603245 no 2428 0.246092497042496 3631 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3228 9131799 49.47 µM -0.688540236208538 0.278714076076316 no 2429 0.245556320695476 3636 17015818
SGTC_2101 5377231 179.231 µM -0.690410691078726 0.278105789536665 no 2430 0.244967977696632 3658 2844213
SGTC_196 k015-0023 18.111 µM -0.690962653838549 0.277926410757256 no 2431 0.244794505384862 3661 5211998
SGTC_338 4055-0136 114 µM -0.69131339960619 0.277812453527004 no 2432 0.244684306450081 3623 2900563
SGTC_3196 9111891 49.47 µM -0.691316598339796 0.277811414364076 no 2433 0.244683301580024 3672 18891510
SGTC_2728 chlorpromazine 9.18 µM -0.69297243567156 0.277273742408488 no 2434 0.244163424971779 3667 2726 A thorazine and dopamine antagonist.
SGTC_817 1391-0715 46 µM -0.696278019344317 0.276201900897279 no 2435 0.243127367943934 3643 1353946
SGTC_586 0957-0265 8.15 µM -0.696724533311103 0.276057273972114 no 2436 0.24298760117056 3573 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_128 0906-2981 13.371 µM -0.697572691169139 0.275782656083997 no 2437 0.242722232483914 3636 6740226
SGTC_3145 9085516 49.47 µM -0.69851069580274 0.275479103886298 no 2438 0.242428935634538 3690 25236195
SGTC_82 0054-0107 293.755 µM -0.698700496774638 0.275417701478249 no 2439 0.242369611715374 3673 3104697
SGTC_1954 st077032 68.9 µM -0.698782026242339 0.275391327992581 no 2440 0.242344131397319 3595 698907
SGTC_1260 0700-1617 7.75 µM -0.700511209852354 0.274832257456519 no 2441 0.241804053500508 3683 2853078
SGTC_3275 9138069 49.47 µM -0.70100023342139 0.274674250471475 no 2442 0.2416514347694 3723 17617007
SGTC_3285 9112818 20.8695 µM -0.701828199496156 0.274406830935417 no 2443 0.241393155179021 3710 17017947 YPR165W RHO1
SGTC_3015 9080845 49.47 µM -0.702632064456203 0.27414731867533 no 2444 0.241142537354089 3723 5296973
SGTC_892 0929-0076 29 µM -0.703311506908457 0.273928068398258 no 2445 0.240930820596971 3687 5751038
SGTC_328 k915-0120 63.5 µM -0.703343012316565 0.273917903975277 no 2446 0.240921005849812 3662 6624543
SGTC_504 lovastatin 124 µM -0.705250432455588 0.273302870691439 no 2447 0.240327200632105 3663 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1978 st071761 42 µM -0.705620289444653 0.273183692305659 no 2448 0.240212151605643 3686 5147680
SGTC_1766 st045414 44.774 µM -0.710366848379672 0.27165650636042 no 2449 0.238738337791319 3733 253960
SGTC_2842 9000675 19.48 µM -0.71097797078074 0.271460189514777 no 2450 0.238548943490344 3666 2989072
SGTC_641 4092-0595 30 µM -0.711842721555321 0.271182517949397 no 2451 0.238281087240713 3714 786260
SGTC_2836 9010338 19.48 µM -0.711908738268931 0.271161325795175 no 2452 0.238260645357684 3640 2994051
SGTC_1196 1588-0294 184 µM -0.712885739537007 0.270847793281996 no 2453 0.237958232100215 3698 6144269
SGTC_3070 9117005 49.47 µM -0.71333968986312 0.270702176263106 no 2454 0.23781779153599 3728 8779016
SGTC_567 1080-0542 68.4 µM -0.715393641190351 0.270043804010157 no 2455 0.237182920295187 3634 5950415
SGTC_1223 0764-0573 147 µM -0.71617634087413 0.269793128939588 no 2456 0.236941234998138 3710 1609797
SGTC_1275 0867-0008 21.1 µM -0.717763891834189 0.269285042418518 no 2457 0.236451440371974 3691 3422836
SGTC_3030 9087619 49.47 µM -0.717938524111705 0.269229181676901 no 2458 0.236397596490279 3694 25236973
SGTC_2710 st078562 53.7235 µM -0.717969078589207 0.269219408618585 no 2459 0.236388176407517 3682 17250908
SGTC_415 dibenzyl ketone 100 µM -0.719475207361429 0.268737883740234 no 2460 0.235924086373363 3714 7593
SGTC_2457 5731572 11.68 µM -0.720002298099945 0.268569469664172 no 2461 0.235761790306872 3733 2865357
SGTC_254 nsc-64875 3.808 µM -0.720630710591311 0.268368750985333 no 2462 0.235568376821224 3718 56993
SGTC_347 4534-1311 26.2 µM -0.721496509480291 0.268092333313659 no 2463 0.235302043732485 3709 2862016
SGTC_658 3253-0951 102 µM -0.721625068343769 0.268051301430086 no 2464 0.235262511222879 3725 1184878
SGTC_592 k241-0073 46.5 µM -0.72244076842574 0.267791029702901 no 2465 0.235011764733388 3708 4230158
SGTC_1862 st057513 3.81 µM -0.723053474707874 0.267595612548262 no 2466 0.234823515756589 3692 5393163
SGTC_1492 4158-0558 28.5 µM -0.723434722945315 0.267474053147074 no 2467 0.234706422444581 3723 3967268
SGTC_1502 4534-4282 27.7 µM -0.723925801654424 0.267317515808228 no 2468 0.234555644329494 3691 3278949
SGTC_482 fipronil 114 µM -0.723959326890402 0.267306830915347 no 2469 0.234545352878844 3749 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_206 4546-0025 72.014 µM -0.7250102306349 0.266972004633905 no 2470 0.234222877067576 3729 6620745 YIL048W NEO1
SGTC_381 3461-2219 42.7 µM -0.725092622978238 0.266945762736405 no 2471 0.234197604887403 3694 2883159
SGTC_1044 1222-0021 1.78 µM -0.725199154503511 0.266911834459685 no 2472 0.23416493074085 3735 4306703
SGTC_2492 derrusnin 100 µM -0.7269598416764 0.266351404586661 no 2473 0.233625278389778 3654 1715307 Part of coumarin class of compounds.
SGTC_303 1348-1668 34.2 µM -0.727829955894786 0.266074665687028 no 2474 0.233358842334783 3734 5380509
SGTC_2815 7968870 71.43 µM -0.728399736931044 0.265893526368644 no 2475 0.233184462132543 3723 2977326 YHR190W ERG9
SGTC_351 caspofungin 25 nM -0.729950895201396 0.265400713838552 no 2476 0.2327101003423 3758 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1240 0356-0016 42.1 µM -0.730001343302485 0.265384693952493 no 2477 0.232694681751039 3718 4305613
SGTC_1353 1498-1206 8.11 µM -0.730987009564774 0.265071792336667 no 2478 0.232393543821356 3764 6756808
SGTC_623 k072-0108 16.9 µM -0.73158271394803 0.26488277575488 no 2479 0.232211651071265 3722 5382803
SGTC_1842 st055362 61.2 µM -0.731870376717659 0.264791525094735 no 2480 0.232123844314686 3719 676032
SGTC_430 0958-0115 16.4 µM -0.734441706782989 0.263976573713577 no 2481 0.231339787858835 3713 6833180
SGTC_572 0960-0087 17.7 µM -0.734599969785969 0.263926455997239 no 2482 0.231291578206335 3751 6796365
SGTC_1331 1472-0049 76.2 µM -0.73572408846824 0.263570616902701 no 2483 0.23094931349338 3698 24051409
SGTC_929 2805-0021 398 µM -0.736601470609726 0.263293052315459 no 2484 0.230682370195666 3797 3098024
SGTC_600 1495-0418 41.6 µM -0.737167498519001 0.263114065572794 no 2485 0.230510247860397 3742 5377768
SGTC_2951 9072950 58.06 µM -0.737690240254851 0.262948821824203 no 2486 0.230351352111145 3751 16488155
SGTC_1822 st052468 42 µM -0.738680714903809 0.262635868712003 no 2487 0.230050449452223 3740 2873678
SGTC_3217 9129673 49.47 µM -0.740038988670681 0.262207014872958 no 2488 0.229638168590559 3724 17248312
SGTC_1289 0976-0073 69.1 µM -0.740343053440201 0.262111060317559 no 2489 0.229545931638892 3772 3391136
SGTC_852 0418-0143 439 µM -0.743274461704485 0.261186911688611 no 2490 0.22865776497301 3783 5369229
SGTC_3338 9144300 39.5675 µM -0.743350524665059 0.261162954571594 no 2491 0.228634744909519 3761 4901274
SGTC_2306 7482397 179.52 µM -0.746563831897788 0.260151910108685 no 2492 0.227663443673545 3737 891448
SGTC_835 0312-0010 67.2 µM -0.747060808725478 0.259995720195707 no 2493 0.227513427885528 3707 1626196
SGTC_2892 9047358 58.44 µM -0.748230336882215 0.259628351698026 no 2494 0.227160617714909 3749 6466771
SGTC_161 4065-0411 162.148 µM -0.748586887032106 0.259516406614214 no 2495 0.227053119026987 3793 1906281 YLR208W SEC13
SGTC_1680 diphenhydramine 100 µM -0.748738048457351 0.259468954396396 no 2496 0.227007553017699 3779 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2652 actinonin 100 µM -0.750539407217075 0.258903821438879 no 2497 0.226464949533198 3731 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_911 3456-4043 236 µM -0.752542658603826 0.25827609819328 no 2498 0.225862393136862 3844 914281
SGTC_2132 5317594 122.667 µM -0.75327269443892 0.258047536116754 no 2499 0.225643031847287 3736 794577
SGTC_1393 3470-5649 58.2 µM -0.754737625192922 0.257589207317581 no 2500 0.2252032130617 3724 4108395
SGTC_1899 st063254 59.6 µM -0.755852756310431 0.257240602954722 no 2501 0.224868741016856 3700 3093813
SGTC_1518 st038567 90.8 µM -0.75608293114961 0.257168677880351 no 2502 0.224799737534934 3752 77966
SGTC_778 3456-2434 196 µM -0.756423618500541 0.257062239032077 no 2503 0.224697625851066 3804 5539063
SGTC_3245 9134821 49.47 µM -0.757466284713493 0.25673662768106 no 2504 0.224385278774187 3780 17014901
SGTC_1936 st074407 74.3 µM -0.758563680243793 0.256394157123225 no 2505 0.22405680301583 3800 809813
SGTC_1624 st003710 6.25 µM -0.759485845086918 0.256106556001918 no 2506 0.223780989173781 3767 24207033
SGTC_3000 9075062 71.4286 µM -0.759767098817813 0.256018873196861 no 2507 0.223696906334417 3742 17057871
SGTC_1891 st059073 26.2 µM -0.760378568538826 0.25582829731055 no 2508 0.223514165025194 3773 688754
SGTC_49 0717-0965 32.132 µM -0.760959714995896 0.255647240884695 no 2509 0.223340564731865 3825 5889349 YGL099W LSG1
SGTC_115 0527-0192 112.043 µM -0.761042010634237 0.255621607053667 no 2510 0.223315987550658 3814 4233931
SGTC_2947 9072639 7.68 µM -0.761512439724156 0.255475101369581 no 2511 0.2231755258032 3793 16488146
SGTC_2106 5357045 167.29 µM -0.762559155218861 0.255149280343699 no 2512 0.222863175723383 3805 668842
SGTC_1298 1079-1278 263 µM -0.762872940212498 0.255051647878152 no 2513 0.222769587776919 3806 2840950
SGTC_419 nsc-638432 893 µM -0.763653115241774 0.254808985460676 no 2514 0.222536993758757 3755 368090
SGTC_374 0880-0231 82.3 µM -0.763773688106916 0.254771493760276 no 2515 0.222501059660864 3731 6833587
SGTC_509 pifithrin 175 µM -0.764395235957533 0.25457827150942 no 2516 0.22231587345674 3810 4817 A p53 inhibitor.
SGTC_1325 1431-0015 227 µM -0.766666666473968 0.253872799187566 no 2517 0.221639863601554 3736 1103340
SGTC_2300 7976697 71.57 µM -0.766706082195401 0.253860566318364 no 2518 0.221628143303368 3712 2236109
SGTC_2731 amoxapine 43.43 µM -0.767097138563851 0.253739216753794 no 2519 0.221511881550582 3827 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1292 0kpi-0043 232 µM -0.768003776810432 0.253457993048601 no 2520 0.221242470542498 3810 3333905
SGTC_2124 5246320 200 µM -0.768367764590049 0.253345136349129 no 2521 0.221134362937901 3802 579342
SGTC_1452 4194-0072 190 µM -0.76927582109035 0.253063702915243 no 2522 0.220864793885989 3776 1343545
SGTC_2889 9059656 51.95 µM -0.769990917014341 0.252842189458927 no 2523 0.220652640317976 3875 3949838
SGTC_2018 5133068 143 µM -0.77047352206845 0.252692751819147 no 2524 0.220509527786722 3777 785362
SGTC_888 0916-0002 6.97 µM -0.770903716380364 0.252559582276891 no 2525 0.220382002077586 3879 2802138 YIL048W NEO1
SGTC_2811 7967822 32.47 µM -0.771593502501136 0.252346131540727 no 2526 0.220177611894417 3849 2232244
SGTC_251 melphalan 456.522 µM -0.773122369948591 0.251873370628961 no 2527 0.219724981653692 3842 460612 A DNA alkylator.
SGTC_2391 6285546 200 µM -0.773876178021802 0.251640448067341 no 2528 0.219502009100361 3791 846083
SGTC_3029 9088683 49.47 µM -0.777542991661222 0.250509047505734 no 2529 0.218419240120286 3789 25236615
SGTC_628 1636-0253 16 µM -0.779188596593835 0.250002171427578 no 2530 0.217934313246739 3823 4456143
SGTC_3306 9127676 59.7925 µM -0.779204787195515 0.249997187134418 no 2531 0.217929545286192 3800 41905287
SGTC_3009 9080819 71.4286 µM -0.779604872180424 0.249874037318429 no 2532 0.217811743609238 3836 17027216
SGTC_1594 piperine 70.1 µM -0.782280976535401 0.249051136670758 no 2533 0.217024732124047 3784 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1752 st044819 83.042 µM -0.782327996086645 0.249036691084347 no 2534 0.217010918921913 3810 441209 YML126C ERG13
SGTC_2004 4023728 41.89 µM -0.783133222212237 0.248789374610083 no 2535 0.216774441912266 3813 360084 YDR527W RBA50
SGTC_2677 mitomycin C 100 µM -0.783982214256869 0.248528757596979 no 2536 0.216525273275757 3815 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2102 5377816 72.7585 µM -0.785172281755797 0.248163684873204 no 2537 0.216176282315037 3824 1379702
SGTC_843 0310-0051 143 µM -0.786437859000997 0.24777576233021 no 2538 0.215805505518733 3840 2065037
SGTC_191 3914-0123 66.505 µM -0.787487754191314 0.247454196140903 no 2539 0.215498197107781 3761 3144412
SGTC_2678 equilin 100 µM -0.788331695839063 0.247195872019565 no 2540 0.215251356221829 3816 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_503 tyrphostin 8 294 µM -0.788343509711898 0.247192256906703 no 2541 0.215247901997643 3764 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1768 st044301 37.178 µM -0.788379536531873 0.247181232667686 no 2542 0.215237368418357 3818 3931349
SGTC_2477 5967686 25.23 µM -0.790466897882613 0.246542947418049 no 2543 0.214627573362832 3831 776118
SGTC_1321 1326-2144 215 µM -0.793837808109685 0.24551403850055 no 2544 0.213644929558086 3839 3513030
SGTC_2617 dihydrotanshinone i 20.83 µM -0.79400670706607 0.245462545930666 no 2545 0.213595763385611 3835 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_972 1319-0219 195 µM -0.794191564499572 0.245406194719108 no 2546 0.213541959287044 3800 23903702
SGTC_1328 1441-0025 69.2 µM -0.794892885312543 0.245192470080336 no 2547 0.21333790660242 3778 4562601
SGTC_3102 9121669 49.47 µM -0.795124162409508 0.245122011285746 no 2548 0.213270640345015 3834 41905072
SGTC_3019 9081971 49.47 µM -0.795674598137535 0.244954364308105 no 2549 0.213110597498126 3831 16451803
SGTC_3209 9113616 49.47 µM -0.796643393978834 0.244659446718109 no 2550 0.212829083892622 3792 16649353
SGTC_2857 9024691 58.44 µM -0.797896821007224 0.244278166549187 no 2551 0.212465184173629 3910 16478292
SGTC_1928 4'-methoxychalcone 40.3 µM -0.798818259942909 0.243998078301576 no 2552 0.212197900489576 3888 641818
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.798906088899175 0.243971390127675 no 2553 0.212172434028766 3894 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_748 act1.228 77.9 µM -0.800000400845587 0.243638998768721 no 2554 0.211855282461835 3774 4421505 YNR035C ARC35
SGTC_1974 st069448 26.9 µM -0.800344801213515 0.24353443962487 no 2555 0.211755526361497 3815 6323587 YNR016C ACC1
SGTC_2317 5986382 200 µM -0.800679013630052 0.243432996695878 no 2556 0.211658747502015 3863 877883
SGTC_2259 7964009 200 µM -0.806649978874262 0.241624493076485 no 2557 0.209934085265741 3882 313134
SGTC_1896 st058441 89 µM -0.806985753484108 0.241523009755965 no 2558 0.209837345546866 3868 688759
SGTC_297 0986-0032 24 µM -0.809509982089864 0.24076083751631 no 2559 0.209110931721943 3815 2847425
SGTC_1004 4084-0029 199 µM -0.809813641777188 0.240669237987353 no 2560 0.209023645470389 3885 716894 YLR208W SEC13
SGTC_1411 3909-8223 150 µM -0.811542142187241 0.240148193994635 no 2561 0.208527201018207 3834 X1411
SGTC_1366 1683-0113 21.9 µM -0.812293633934781 0.239921854139075 no 2562 0.208311581285791 3858 708623
SGTC_531 3788-1495 174 µM -0.812493501076836 0.23986167626408 no 2563 0.208254257097547 3821 2896655
SGTC_2549 cedrol 20.94 µM -0.812526893791123 0.239851622875029 no 2564 0.208244680591642 3772 6708665 A sedative which affects the nervous system.
SGTC_3169 9102970 49.47 µM -0.813636407599606 0.239517717448558 no 2565 0.20792663722326 3918 17027839
SGTC_757 1066-0008 322 µM -0.814544738529038 0.239244546557523 no 2566 0.207666476788742 3895 6842497
SGTC_2945 9067681 61.76 µM -0.814803230991872 0.239166838817054 no 2567 0.20759247560043 3944 16456930
SGTC_1856 st057054 55.7 µM -0.815865850807044 0.238847540076422 no 2568 0.207288432671235 3844 1266018
SGTC_2253 7938677 135.83 µM -0.818076922983852 0.238183899355693 no 2569 0.206656632537341 3925 2301972
SGTC_1425 4048-4433 7.33 µM -0.819052672303127 0.237891355372221 no 2570 0.206378181287622 3904 23734946
SGTC_1787 fluconazole 80 µM -0.819632783862321 0.237717522833716 no 2571 0.206212739294667 3707 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_316 k060-0003 58.6 µM -0.820090460119653 0.237580427667961 no 2572 0.20608227011904 3837 6152314
SGTC_2781 5567276 71.43 µM -0.820457837309898 0.237470412641317 no 2573 0.20597757780435 3920 2853274
SGTC_2173 5763948 167 µM -0.822187930863636 0.236952693773214 no 2574 0.205484973339455 3861 2867177
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.822670779750707 0.236808315307531 no 2575 0.205347618151597 3867 688662
SGTC_1851 st056236 18.9 µM -0.823406296388029 0.23658847870541 no 2576 0.205138491846056 3833 5393171
SGTC_335 4077-0256 27.6 µM -0.823473420657974 0.236568421704632 no 2577 0.205119412993166 3851 3121989
SGTC_1608 st001473 40.5 µM -0.82545780805405 0.235975901663322 no 2578 0.204555863495945 3839 7292267
SGTC_2786 7743617 45.45 µM -0.826521637249964 0.235658588996749 no 2579 0.204254124597808 3829 583674
SGTC_2726 cimetidine 79.27 µM -0.827813804606892 0.235273485710607 no 2580 0.203887977765275 3858 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2234 tolnaftate 200 µM -0.828909212947017 0.234947294613914 no 2581 0.203577890877118 3865 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1659 st012954 42.1 µM -0.829335233861795 0.234820501475343 no 2582 0.203457369387447 3876 24207262
SGTC_3066 9117245 49.47 µM -0.829889906610175 0.234655475433657 no 2583 0.203300516043825 3939 17176980
SGTC_424 splitomicin 100 mM -0.829988909167827 0.234626026974014 no 2584 0.203272527159556 3978 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_372 0155-0182 15.9 µM -0.831511297680111 0.234173447670743 no 2585 0.202842424320855 3817 771486
SGTC_2649 anisomycin 9.56 µM -0.832106236566847 0.233996714257883 no 2586 0.202674490960086 3869 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3312 9133330 71.43 µM -0.833616881653608 0.233548291987667 no 2587 0.202248454769239 3937 17617324
SGTC_2440 5628896 157.78 µM -0.833812760976708 0.233490181784512 no 2588 0.202193251618193 3894 5522048
SGTC_177 1327-0068 8.361 µM -0.834307951534576 0.233343312697612 no 2589 0.202053736108089 3877 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1111 tnp00062 510.699 nM -0.834529678599829 0.233277567053393 no 2590 0.201991285168844 3943 676306
SGTC_2958 9077254 16.72 µM -0.83458871990211 0.233260062090147 no 2591 0.201974657731618 3929 16457351
SGTC_1877 wortmannin 25 µM -0.83489090345068 0.23317048008997 no 2592 0.201889568473714 3891 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1170 0310-0127 64.8 µM -0.835435833317603 0.233008984477934 no 2593 0.201736180630181 3892 774975
SGTC_130 0136-0219 337.655 µM -0.836067546537898 0.232821847489548 no 2594 0.201558452229884 3774 234244
SGTC_1758 st042942 75.2445 µM -0.837053068294576 0.232530066064472 no 2595 0.201281369511532 3810 669317
SGTC_3161 9100388 49.47 µM -0.837099213269784 0.232516409000232 no 2596 0.201268401297234 3916 25236368
SGTC_1360 1598-0022 39.8 µM -0.838902092665143 0.231983178179152 no 2597 0.200762126697576 3947 761525
SGTC_2816 7982706 58.44 µM -0.839632137746884 0.231767449346335 no 2598 0.20055733709915 3960 2981853
SGTC_290 2043-6722 48.1 µM -0.84000955564619 0.231655965934015 no 2599 0.200451514404933 3917 773758 YLR208W SEC13
SGTC_1080 nisoldipine 24.4 µM -0.841175290035507 0.231311814791463 no 2600 0.200124870636468 3866 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_868 0527-0199 213 µM -0.843067715425567 0.230753735771977 no 2601 0.199595286700783 3853 2849450
SGTC_670 4204-0025 119 µM -0.844610943790304 0.230299192750172 no 2602 0.199164048385485 3905 719039
SGTC_931 2812-0076 566 µM -0.845411223458177 0.230063675390858 no 2603 0.198940640128866 3894 3450959
SGTC_2593 nobiletin 86.24 µM -0.8528194798584 0.227889880829245 no 2604 0.196879709800479 3919 72344 An anti-infammatory.
SGTC_2865 9030313 51.95 µM -0.852970391806091 0.227845719376743 no 2605 0.196837861837575 3849 42562754
SGTC_1100 amiodarone 5.07 µM -0.853050409890172 0.227822305591201 no 2606 0.196815674965747 3992 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_895 0964-0006 13.7 µM -0.853729688433066 0.227623599036634 no 2607 0.196627390216201 3873 6738897
SGTC_544 k015-0020 52.4 µM -0.855049147287847 0.227237902166099 no 2608 0.196261970068362 3923 3008304
SGTC_1065 prochlorperazine maleate 2.48 µM -0.857545628441345 0.226509153346894 no 2609 0.195571704593319 3943 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1788 fluconazole 20 µM -0.857715588996615 0.226459588112845 no 2610 0.195524764944061 3964 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3208 9114115 49.47 µM -0.858461841645923 0.226242032539573 no 2611 0.195318746117877 3945 650895
SGTC_2140 5586273 200 µM -0.859400853571062 0.225968449561995 no 2612 0.195059699482162 3869 854421
SGTC_153 4077-0274 519.67 µM -0.859421137831549 0.225962541767211 no 2613 0.195054105938155 3922 3121976
SGTC_2996 9066192 71.4286 µM -0.860073149890332 0.225772689651148 no 2614 0.194874360441427 3988 6472854
SGTC_1059 3448-6867 171 µM -0.860150775116022 0.225750092839753 no 2615 0.194852967572894 3849 3934407
SGTC_1697 st025554 27.742 µM -0.860330477385179 0.225697786167983 no 2616 0.194803448598357 3884 1269519
SGTC_3022 9087993 49.47 µM -0.860834679404097 0.225551062644876 no 2617 0.194664550953232 3957 17173644
SGTC_855 0428-0020 25 µM -0.862675933607354 0.225015713741024 no 2618 0.194157833996529 3938 6812414
SGTC_2556 citropten 84.59 µM -0.863899870259097 0.224660250126464 no 2619 0.193821449057289 3970 2775 A potential DNA crosslinker.
SGTC_2074 5212007 75.395 µM -0.864636759788388 0.224446391592316 no 2620 0.193619094864936 3773 758611
SGTC_866 0495-0101 262 µM -0.864987547539064 0.224344627309624 no 2621 0.193522811768169 3872 635694
SGTC_173 1273-0061 2.693 µM -0.867786568855889 0.223533564067264 no 2622 0.192755592050973 3930 2847414 YPL266W DIM1
SGTC_1441 4106-0040 13 µM -0.868567059247816 0.223307701647915 no 2623 0.192541989211578 3903 2904180
SGTC_2934 9036370 36.88 µM -0.869391811169038 0.223069171793371 no 2624 0.192316430278232 3949 6462800
SGTC_45 0kpi-0036 14.9 µM -0.869790688029909 0.222953863068521 no 2625 0.19220740064123 3959 2795021
SGTC_1153 4055-0057 267 µM -0.869822545235626 0.22294465513985 no 2626 0.192198694372697 3966 882706
SGTC_3241 9133421 49.47 µM -0.872067880801316 0.222296214743156 no 2627 0.191585673555126 3927 17018221
SGTC_1588 farnesol 29.9 µM -0.873325173503834 0.221933586083324 no 2628 0.191242931589815 3924 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_345 1362-0200 395 µM -0.873731165552912 0.221816561950395 no 2629 0.191132337205889 3942 1419823
SGTC_909 3448-9333 149 µM -0.874374419177536 0.221631221147446 no 2630 0.190957191819776 3853 3344074
SGTC_3110 9122132 49.47 µM -0.874787369103513 0.221512284455765 no 2631 0.190844805531911 4041 918317
SGTC_2370 9071495 200 µM -0.875129011071464 0.221413913268974 no 2632 0.190751856726715 3955 21791103
SGTC_524 r073-0010 27.8 µM -0.879564422119428 0.22013906578157 no 2633 0.189547659742451 3865 2772106
SGTC_997 3996-0078 137 µM -0.881050112379448 0.219712984561391 no 2634 0.189145348602787 3983 735687
SGTC_3253 9135987 49.47 µM -0.882807087513752 0.21920971313543 no 2635 0.188670255236065 3924 4182430
SGTC_1627 st003713 25.6 µM -0.883409499504921 0.219037309732794 no 2636 0.188507530031532 4012 16195070 YER133W GLC7
SGTC_190 3970-0790 3.722 µM -0.883655157231794 0.218967027697756 no 2637 0.188441197132317 3854 2832352
SGTC_1061 3448-9325 110 µM -0.884378670358594 0.218760107854448 no 2638 0.18824591659073 3847 723482
SGTC_3103 9120822 49.47 µM -0.886698276245158 0.218097475509013 no 2639 0.187620683329354 3953 17141819
SGTC_11 0438-0307 1.3 µM -0.888594211566369 0.217556731700797 no 2640 0.187110601543736 3937 4011476
SGTC_2393 9031399 185.94 µM -0.890071090870935 0.217136044438514 no 2641 0.186713857348659 4006 1526623 YDL150W RPC53
SGTC_821 1114-0266 29.2 µM -0.890168811737039 0.217108225356654 no 2642 0.186687624305319 3985 3123235
SGTC_2674 ligustilide 100 µM -0.89044561533929 0.217029436353156 no 2643 0.186613329113507 4015 5319022 A signalling regulator.
SGTC_2353 9059630 146.67 µM -0.890517526647496 0.217008970319747 no 2644 0.186594030827542 4009 4779114
SGTC_1622 st003707 19.4 µM -0.890760294495365 0.216939886575783 no 2645 0.186528890211311 3989 10140899
SGTC_1495 4469-0029 237 µM -0.89087095513603 0.216908400415839 no 2646 0.18649920189866 3974 793680
SGTC_35 0133-0054 64.071 µM -0.891052594950826 0.216856724350387 no 2647 0.186450477460679 3967 99677
SGTC_932 2857-0803 154 µM -0.892332479793738 0.216492802190012 no 2648 0.186107375025094 4048 674898
SGTC_2872 9044037 25.97 µM -0.894142549708389 0.21597873109247 no 2649 0.18562281294243 3959 6465195
SGTC_1775 st081588 35.1725 µM -0.89420027739093 0.215962347717369 no 2650 0.185607371931247 3974 1426443 YGL099W LSG1
SGTC_1087 pterostilbene 9.05 µM -0.894269349933477 0.215942745566363 no 2651 0.185588897442212 4022 5281727 Similar to reservatol, lowers cholesterol.
SGTC_615 k087-0205 167 µM -0.895065853172666 0.21571677978201 no 2652 0.185375943140017 3948 9642773
SGTC_987 1497-1013 404 µM -0.896999309519259 0.215168834093051 no 2653 0.184859642735145 3905 1676435
SGTC_798 1287-0182 476 µM -0.89812156534422 0.214851155302014 no 2654 0.184560371544259 3984 1649755
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.899657914203356 0.214416700631454 no 2655 0.184151163343214 4008 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1500 4488-1866 171 µM -0.899777182369033 0.214382994900943 no 2656 0.184119419776418 4039 2900003
SGTC_2725 haloperidol 53.21 µM -0.900175631012707 0.214270413831945 no 2657 0.184013396218379 3921 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3227 9130768 49.47 µM -0.900522036289545 0.214172565491183 no 2658 0.183921251822721 3990 17720899
SGTC_2434 5670830 169.91 µM -0.902229816154937 0.213690552838926 no 2659 0.18346739959955 4018 1549830
SGTC_1255 0566-0045 221 µM -0.903453316260769 0.213345614690802 no 2660 0.183142677097482 4018 2788469
SGTC_1736 st036774 51 µM -0.904017487588431 0.21318666877457 no 2661 0.182993064300406 4055 1272247
SGTC_500 h-89 112 µM -0.906247415861642 0.212559099802628 no 2662 0.182402455570143 4020 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2723 salbutamol 83.58 µM -0.90914447159558 0.211745394751525 no 2663 0.181636935312392 4000 9884233 β2-adrenoceptor agonist
SGTC_2177 5811945 192 µM -0.909626477833615 0.21161018925497 no 2664 0.181509764959339 4020 5343475
SGTC_1955 wogonin 32.4 µM -0.909641497621237 0.211605976931055 no 2665 0.181505803101853 4070 5281703 A flavanone.
SGTC_1094 duloxetine 25.4 µM -0.912877894205846 0.210699469582933 no 2666 0.180653382473114 3978 60834 A selective serotonin reuptake inhibitor.
SGTC_2990 9074105 71.4286 µM -0.913055760033776 0.210649715898793 no 2667 0.180606608040441 3916 6502001
SGTC_809 3998-0021 90 µM -0.913411244540944 0.210550298322167 no 2668 0.180513146929971 3939 715485
SGTC_751 0833-0568 350 µM -0.913849841334617 0.210427674866158 no 2669 0.180397876422326 4040 6954252
SGTC_650 1328-0195 38 µM -0.913926291265185 0.210406305187467 no 2670 0.180377788840751 3946 2780821
SGTC_580 1123-0028 41 µM -0.915164470644364 0.210060380346998 no 2671 0.180052646789858 4044 1677248 YPR107C YTH1
SGTC_2537 larixol 68.93 µM -0.919710133557197 0.208793273054292 no 2672 0.178862127843718 3994 6708759
SGTC_1063 disulfiram 1.84 µM -0.922214650942226 0.208097065389846 no 2673 0.178208311234932 3981 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_535 2293-4129 48.2 µM -0.922258095893997 0.208085000631357 no 2674 0.178196983023937 4019 396118 YIL048W NEO1
SGTC_2749 bexarotene 57.39 µM -0.923034240424829 0.207869533170094 no 2675 0.177994680900384 4039 82146 An retinoic acid receptor inhibitor.
SGTC_1477 0139-0234 16 µM -0.924285969765099 0.207522315120256 no 2676 0.177668722812368 4009 620880
SGTC_2905 7799065 20.05 µM -0.925225374605154 0.207261958271086 no 2677 0.177424343528443 3917 1296806
SGTC_3151 9099821 49.47 µM -0.925878484453217 0.207081062206732 no 2678 0.177254566901674 3984 17174189
SGTC_3053 9095903 49.47 µM -0.927515608734199 0.206628028008536 no 2679 0.176829445730304 4098 17174018
SGTC_989 1501-0895 10.3 µM -0.927645234814655 0.206592182248635 no 2680 0.176795812561426 3956 2830112
SGTC_2563 tomatine 8.54 µM -0.927647638916752 0.206591517472252 no 2681 0.176795188824133 3884 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1175 0741-0056 27.6 µM -0.927662230886751 0.206587482563874 no 2682 0.176791403009823 4104 765927
SGTC_2778 tioconazole 65.09 nM -0.928281161318466 0.206416381580204 no 2683 0.17663087176292 3903 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3046 9092212 49.47 µM -0.931154465301453 0.205623167917262 no 2684 0.175886834086315 4058 25236637
SGTC_1660 st012960 28.1 µM -0.931403066375376 0.20555462344603 no 2685 0.17582255264934 4012 24207266
SGTC_2804 7954240 19.48 µM -0.931435141552263 0.205545780642774 no 2686 0.17581425997 4056 828705
SGTC_1607 st000305 50.6 µM -0.932068473572145 0.205371223643813 no 2687 0.175650569780675 4024 5457690
SGTC_1138 3761-0006 1.03 µM -0.932803032828672 0.20516887702843 no 2688 0.175460837521655 3992 12061087
SGTC_2598 perillyl alcohol 100 µM -0.93290052740243 0.205142029427902 no 2689 0.175435665025713 4045 10819 An apoptosis inducer.
SGTC_2968 9090663 33.37 µM -0.933698724810591 0.204922304078122 no 2690 0.17522966149401 3981 25236811
SGTC_2869 9037858 32.47 µM -0.934101041867386 0.204811608522797 no 2691 0.175125887287658 3965 27187042
SGTC_2636 apigenin dimethyl ether 100 µM -0.937041491862351 0.204003638535471 no 2692 0.174368607691931 4034 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1931 st074438 57.1 µM -0.938290792909038 0.203660934137418 no 2693 0.174047495017281 3984 2787313
SGTC_722 3534-0461 190 µM -0.938881097308109 0.203499123154023 no 2694 0.173895897664473 4069 658262
SGTC_318 1488-0629 67.2 µM -0.939100228252242 0.203439075711793 no 2695 0.173839643548924 4070 3662576
SGTC_3005 9076496 71.4286 µM -0.939486908957179 0.203333141168386 no 2696 0.173740405195911 4009 21368410
SGTC_1199 1638-0010 4.46 µM -0.939875605975633 0.203226687419491 no 2697 0.173640685700307 4007 3111136
SGTC_1445 4239-0156 97.7 µM -0.940135598535598 0.203155500960228 no 2698 0.173574005423082 4126 4008346
SGTC_1062 mesoridazine 14.2 µM -0.941120777833439 0.202885892086497 no 2699 0.173321484421256 4023 4078 A neuroleptic.
SGTC_606 k015-0008 38.6 µM -0.94195021189044 0.20265907099824 no 2700 0.17310906546598 4107 1970475
SGTC_3122 9126309 49.47 µM -0.942145645632824 0.202605648801764 no 2701 0.17305903882291 4054 17591206
SGTC_1527 coumarin 137 µM -0.942232582449326 0.202581887157809 no 2702 0.173036787912809 4128 323 A hepatotoxic, DNA x-linker.
SGTC_1042 0350-0096 82 µM -0.942446225628902 0.202523501100962 no 2703 0.172982115079971 4010 3122515
SGTC_2078 5212016 200 µM -0.942487300085864 0.202512277109442 no 2704 0.172971605091264 3878 1899708
SGTC_3172 9105863 49.47 µM -0.943513263752074 0.202232043312278 no 2705 0.172709217095508 4043 2348785
SGTC_152 4469-0003 551.229 µM -0.943791974898031 0.202155955672295 no 2706 0.17263798117022 3939 697280
SGTC_2818 7996756 12.99 µM -0.944206941086782 0.202042702392024 no 2707 0.172531954462533 4026 2241621
SGTC_2700 st077718 96.8 µM -0.94624564734243 0.201486846968186 no 2708 0.17201165435657 4009 904970
SGTC_3280 9140961 49.47 µM -0.94819544469507 0.200956090885727 no 2709 0.171514982880518 4071 4901226
SGTC_1036 k216-0215 33.5 µM -0.948226742617751 0.200947578096064 no 2710 0.171507017847768 4022 622330
SGTC_1838 st055369 84.5 µM -0.948860734993634 0.200775183722635 no 2711 0.171345723525958 4030 676036
SGTC_3198 9112019 49.47 µM -0.949235162104993 0.200673411700768 no 2712 0.17125051089447 4086 45595555
SGTC_1756 st041558 35.5 µM -0.949853218354392 0.200505487268516 no 2713 0.17109342011485 4126 3955792
SGTC_1478 0453-0656 35.7 µM -0.950761356109552 0.200258901525247 no 2714 0.170862766848084 4029 5258496
SGTC_801 0866-0028 10.1 µM -0.95145189013482 0.200071523523049 no 2715 0.170687514870793 4017 6849771
SGTC_944 3370-0224 231 µM -0.9552780177783 0.199035206186526 no 2716 0.16971856046777 4077 4580514
SGTC_1303 1160-0052 261 µM -0.955451169842905 0.198988384092466 no 2717 0.169674793870471 3991 3562476
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.955486871463819 0.198978730833466 no 2718 0.16966577068856 4005 688803
SGTC_3012 9080433 71.4286 µM -0.955725564970601 0.198914198430903 no 2719 0.169605451505812 4023 17688859
SGTC_789 1309-1135 70.6 µM -0.958729025924641 0.198103270881492 no 2720 0.16884763601378 4022 3092424
SGTC_1479 0549-0158 134 µM -0.959536018465374 0.197885725446882 no 2721 0.168644391797451 4067 5440202
SGTC_764 1951-2361 146 µM -0.961124736672393 0.197457867848907 no 2722 0.168244726655029 4027 5438930
SGTC_2565 isoliquiritigenin 100 µM -0.963877822290974 0.196717760389493 no 2723 0.167553591988089 4142 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2800 7887935 81.82 µM -0.964374090624549 0.196584528345288 no 2724 0.167429203602605 4070 2961002
SGTC_220 paclitaxel 373.376 µM -0.965586671651303 0.196259219500218 no 2725 0.167125523655465 4011 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_260 nsc-65238 3.989 µM -0.96575076289989 0.196215222509296 no 2726 0.167084455784072 4042 3246252
SGTC_2975 9084847 53.72 µM -0.966149720872663 0.196108276791585 no 2727 0.166984633882747 4117 27211724
SGTC_1023 4482-3888 16 µM -0.966153906767273 0.196107154897165 no 2728 0.166983586748389 4086 3303168
SGTC_2006 4011487 200 µM -0.966342750456441 0.196056545469161 no 2729 0.166936350423966 4098 45595294
SGTC_1546 5-methoxyflavanone 78.7 µM -0.967910598196257 0.19563667391934 no 2730 0.166544510441066 4037 147795
SGTC_2094 5332512 191.667 µM -0.968954042842164 0.195357540964211 no 2731 0.166284059748629 4092 755774
SGTC_1419 3993-2473 62.6 µM -0.970651641111398 0.194903932031496 no 2732 0.165860890407818 4115 704026
SGTC_2328 6201408 200 µM -0.97296953654045 0.194285611103051 no 2733 0.165284221402441 4063 2890418
SGTC_1703 st026983 48.3 µM -0.978978166773565 0.192688321618552 no 2734 0.163795383739167 4089 1104023
SGTC_156 3474-0145 5.642 µM -0.980954387590305 0.192164736445219 no 2735 0.163307617569959 3894 2265471
SGTC_2194 5927483 104.545 µM -0.983169124165955 0.1915789936953 no 2736 0.162762104065387 4082 760979
SGTC_2506 ethyl hematommate 54.16 µM -0.986104160460661 0.190804436752367 no 2737 0.162041001129358 4153 3940691 An allergen.
SGTC_77 0828-0286 12.516 µM -0.987528127344079 0.190429344730608 no 2738 0.161691900488684 3989 745345
SGTC_1844 rapamycin 4 nM -0.987653224776768 0.190396414036771 no 2739 0.161661254962404 3983 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1232 0279-0259 161 µM -0.98807615542038 0.19028510752111 no 2740 0.161557676300114 4081 1560000
SGTC_2558 carylophyllene oxide 100 µM -0.990139044220058 0.189742771437754 no 2741 0.161053080783912 4193 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_392 N-ethylmaleimide 8.33 µM -0.99149116583925 0.189387813238912 no 2742 0.160722901963807 4018 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.992145267129316 0.189216245717123 no 2743 0.160563333671348 4037 6708514
SGTC_1724 st037281 8.293 µM -0.993059663317939 0.188976564591731 no 2744 0.160340439835962 4044 574124 YDL195W SEC31
SGTC_3036 9090181 49.47 µM -0.995228156071676 0.188408908375158 no 2745 0.159812655350144 4116 25236586
SGTC_847 0342-0274 5.54 µM -0.995398231279881 0.188364431536099 no 2746 0.159771309253028 4087 18097
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.996929477429066 0.187964282821758 no 2747 0.15939937116397 4139 5393153
SGTC_2040 5100729 123 µM -0.997695446527828 0.187764315109505 no 2748 0.159213530953473 4094 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2546 rhodinyl acetate 100 µM -0.998615704020286 0.187524241935962 no 2749 0.158990444873812 4040 6708682
SGTC_1976 st070609 63.5 µM -1.00047996744032 0.187038481880942 no 2750 0.158539143733422 3995 682556
SGTC_476 mead acid 10 µM -1.0028580335292 0.186419974241276 no 2751 0.157964681737821 4111 5312531 An omega 9 fatty acid.
SGTC_2490 carminic acid 95.39 µM -1.00417978119625 0.186076751299518 no 2752 0.157645982924264 4065 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_307 1501-1223 22.3 µM -1.00522099553795 0.185806651468138 no 2753 0.157395223758578 4123 2830329
SGTC_1642 st009582 77.7 µM -1.00592385092433 0.185624462372409 no 2754 0.157226101026067 4079 6739311
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.00629947000004 0.185527142572769 no 2755 0.157135767680869 4130 279621
SGTC_3335 9143315 29.6265 µM -1.00751269515309 0.185213022329805 no 2756 0.156844230063077 4110 4899691
SGTC_2959 9079155 11 µM -1.00765457181839 0.185176310143936 no 2757 0.156810160404735 4150 16189457
SGTC_2529 gangaleoidin 93.61 µM -1.00768950362821 0.185167271837944 no 2758 0.156801772775843 4119 4565183
SGTC_2571 chrysanthemic acid 100 µM -1.0080427731736 0.185075881772665 no 2759 0.156716964278641 4120 2743 An insecticide.
SGTC_1597 7-benzyloxygramine 47.5 µM -1.01138926497463 0.184211542097195 no 2760 0.155915078554714 4036 260807
SGTC_803 4488-1585 147 µM -1.01189695867245 0.184080633610131 no 2761 0.155793661799843 4091 747204
SGTC_2190 6049624 200 µM -1.01276355534813 0.183857316060782 no 2762 0.155586556187814 3974 2265554
SGTC_289 k017-0060 526 µM -1.01442006728286 0.183430911152568 no 2763 0.155191176429519 4079 5512909
SGTC_1512 0259-0544 12.2 µM -1.01470556158422 0.18335748401982 no 2764 0.155123101113323 4068 18476
SGTC_2315 7733312 200 µM -1.01489416668903 0.183308986162951 no 2765 0.155078139570456 4006 726316
SGTC_579 4491-1009 110 µM -1.01572762592181 0.183094766507263 no 2766 0.15487955438584 4218 1271041
SGTC_1407 3909-7909 12.3 µM -1.01645003632133 0.182909215552274 no 2767 0.154707564338827 4099 4411780
SGTC_1018 4259-0013 28.1 µM -1.01791943517233 0.182532163037156 no 2768 0.154358122292951 4174 6801262
SGTC_3201 9113999 49.47 µM -1.01844357581279 0.182397784399187 no 2769 0.154233601249631 4133 16649224
SGTC_2634 4'-methoxyflavone 100 µM -1.01846058426867 0.182393424824377 no 2770 0.154229561633086 4113 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_271 rotenone 740 µM -1.0190678039018 0.18223782610341 no 2771 0.154085388947693 4174 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1450 4112-4260 37.6 µM -1.01990823187559 0.182022605162339 no 2772 0.153885992545671 4099 1633175
SGTC_2271 7849410 118.62 µM -1.02108340502327 0.181721927627553 no 2773 0.153607462374821 4041 972430
SGTC_2351 9026858 72.31 µM -1.02199165668814 0.181489757127997 no 2774 0.153392424643128 4013 1409300
SGTC_960 1222-0186 7.7 µM -1.02305345809052 0.181218571228982 no 2775 0.153141285419881 4158 3126296
SGTC_3222 9128301 49.47 µM -1.02471009329202 0.180795970936445 no 2776 0.15274999957099 4121 4911358
SGTC_756 0508-1999 28.3 µM -1.02477644276108 0.180779058357915 no 2777 0.152734342105323 4119 6753853
SGTC_970 1315-0089 19.5 µM -1.02534232611481 0.180634854152068 no 2778 0.152600845497919 4057 6811083 YLR033W RSC58
SGTC_380 3970-0968 6 µM -1.0281304287086 0.179925414893341 no 2779 0.151944239421401 4004 2891601
SGTC_448 monastrol 171 µM -1.02904978026374 0.179691867877261 no 2780 0.151728141583693 4034 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2093 5331342 194.4 µM -1.03098642426357 0.179200517053752 no 2781 0.151273593052198 4188 33839
SGTC_621 3584-0052 32.1 µM -1.0326316043132 0.178783778800916 no 2782 0.150888166109101 4135 2273927
SGTC_131 0141-0277 33.849 µM -1.03659585693508 0.177782108214116 no 2783 0.149962122479661 4102 1547771
SGTC_723 4182-0001 115 µM -1.03799469407905 0.177429502620376 no 2784 0.149636262660049 4148 744821 YLR208W SEC13
SGTC_738 1315-0003 72.4 µM -1.03938083913734 0.177080532147817 no 2785 0.149313825853357 4179 6251474
SGTC_1519 esterone 74 µM -1.03966347679041 0.1770094296514 no 2786 0.149248137344429 4103 698 A steroid.
SGTC_340 k038-0059 454 µM -1.04092427227729 0.176692474020655 no 2787 0.148955347839076 4105 23733424
SGTC_1484 3473-2379 286 µM -1.04101575607489 0.176669489571916 no 2788 0.148934117864827 4247 671917
SGTC_1256 0570-0116 285 µM -1.04101683757362 0.176669217866779 no 2789 0.148933866901436 4141 410638
SGTC_2418 pentamidine 31.67 µM -1.04131541365103 0.176594216646183 no 2790 0.148864592684803 4086 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_755 1995-0008 37.3 µM -1.0415773920515 0.176528425215592 no 2791 0.14880382742618 4102 689533
SGTC_933 2914-0560 114 µM -1.04267203161972 0.176253692805453 no 2792 0.148550107770367 4185 463887
SGTC_3273 9137859 49.47 µM -1.04294112811765 0.176186196479364 no 2793 0.148487779897132 4197 2377234
SGTC_3138 9097216 49.47 µM -1.04680389258796 0.175219119212647 no 2794 0.147595017357422 4101 25237486
SGTC_2943 9068529 45.32 µM -1.04794913253619 0.174933046485431 no 2795 0.147331021833446 4119 3270634
SGTC_1072 oxiconazole 14.9 nM -1.04839841068866 0.174820901011743 no 2796 0.147227542746989 4139 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2112 5488546 200 µM -1.0516118098809 0.174020127023565 no 2797 0.146488843592955 4100 600757
SGTC_1401 3807-4679 7.6 µM -1.05230396278399 0.173847949338194 no 2798 0.14633005707256 4088 3291456
SGTC_2833 9001315 45.46 µM -1.05376139486984 0.173485757703209 no 2799 0.145996086165057 4115 2989378
SGTC_2305 7443522 69.23 µM -1.0560622787939 0.172914935218623 no 2800 0.145469881284933 4047 5415886
SGTC_1296 1068-0102 11.9 µM -1.05654878871338 0.172794391231336 no 2801 0.145358781576917 4160 767053
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.05806779487635 0.172418367407714 no 2802 0.145012267783381 4136 390807
SGTC_1034 k072-0165 12.7 µM -1.05952993942231 0.1720569128344 no 2803 0.144679250809562 4172 5835461
SGTC_69 0096-0274 206.684 µM -1.06058161362519 0.171797229312934 no 2804 0.144440041007423 4282 6741392
SGTC_1628 st004252 77.7 µM -1.06169714483002 0.171522051695448 no 2805 0.14418659797602 4182 692968
SGTC_950 1165-0508 94.1 µM -1.06288842353128 0.171228499973863 no 2806 0.143916276732436 4175 6148369
SGTC_966 1300-0360 30.2 µM -1.06485388517245 0.170744878824561 no 2807 0.143471028033492 4134 70588
SGTC_244 nsc-207895 1.295 µM -1.06534167476608 0.170624988944052 no 2808 0.143360670104863 3937 42640
SGTC_1558 st069300 45.6 µM -1.06558613586036 0.170564925095244 no 2809 0.143305384588 4090 24208000
SGTC_1845 st056753 3.01 µM -1.06740485831341 0.170118491875263 no 2810 0.142894527782862 4134 5375839
SGTC_1923 st058458 19.1 µM -1.0683266182421 0.169892518006408 no 2811 0.142686602736051 4175 3534982
SGTC_814 3342-0569 96 µM -1.06953485275366 0.169596605123911 no 2812 0.142414366417154 4239 4346283
SGTC_896 0964-0007 44.5 µM -1.07421263287578 0.168454074267736 no 2813 0.141363695838335 4133 6756758
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.07599626002302 0.168019736188734 no 2814 0.140964464519571 4127 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1049 3226-0134 66 µM -1.07868621396126 0.167366059312399 no 2815 0.14036381668688 4204 5702385
SGTC_582 0987-0078 156 µM -1.07935597248866 0.167203558655807 no 2816 0.140214534938276 4209 1625765
SGTC_2188 6126565 140.678 µM -1.07978829587971 0.167098719907516 no 2817 0.140118232140583 4075 874518
SGTC_2339 9000433 200 µM -1.080977895523 0.166810459919667 no 2818 0.139853473199633 4199 2988954
SGTC_1677 st019204 53.9 µM -1.08191529697676 0.166583537932789 no 2819 0.139645083529936 4203 3945625
SGTC_462 ag-879 158 µM -1.08362886537901 0.16616924015434 no 2820 0.139264693523881 4199 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2465 5809242 33.21 µM -1.0839642667782 0.166088226480331 no 2821 0.139190321340668 4224 2731748
SGTC_2680 butyl paraben 22.24 µM -1.08437055694407 0.165990124344802 no 2822 0.139100266432225 4260 7184 An antifungal and steroid mimetic.
SGTC_2690 usnic acid 100 µM -1.08518491754818 0.165793602981551 no 2823 0.138919881447204 4217 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_446 go6976 132 µM -1.08550660177198 0.16571601565829 no 2824 0.138848670671476 4187 3501 A protein kinase C inhibitor.
SGTC_3088 9117578 49.47 µM -1.08623883608982 0.165539494920645 no 2825 0.138686669711819 4221 678341
SGTC_342 k048-0088 23.3 µM -1.08663865295465 0.165443161868358 no 2826 0.138598267808556 4160 6820570
SGTC_2097 5376186 200 µM -1.08806984045989 0.165098624661523 no 2827 0.138282138398474 4159 742755
SGTC_1839 st053978 48 µM -1.09355289457999 0.163782962479359 no 2828 0.13707555919434 4202 3788398
SGTC_602 3130-1533 38.1 µM -1.09800862032783 0.162718834362978 no 2829 0.136100362555382 4241 720941
SGTC_2416 tofa 880 nM -1.10019145909239 0.162199167959158 no 2830 0.135624355558383 4195 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_965 1291-5240 308 µM -1.10077860466501 0.162059571383113 no 2831 0.135496512858574 4218 2834598
SGTC_1046 2001-0062 216 µM -1.10238956853301 0.161676959269853 no 2832 0.135146172303966 4108 739778
SGTC_2381 9035592 200 µM -1.10285543811655 0.161566422715261 no 2833 0.135044974302569 4190 4749657
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.10328369905059 0.161464853011791 no 2834 0.13495199165405 4201 5106787 A p450 inhibitor.
SGTC_2627 acetyl isogambogic acid 100 µM -1.10330838757629 0.161458998958038 no 2835 0.13494663269914 4220 6857789 A caspase activator and apoptosis inducer.
SGTC_1777 st045864 34.765 µM -1.10426864645383 0.161231413231125 no 2836 0.134738309681973 4187 4691462
SGTC_2689 tacrolimus 100 µM -1.10494385777882 0.161071510445072 no 2837 0.134591958410527 4225 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_317 4495-0002 170 µM -1.10577283567087 0.160875334404453 no 2838 0.134412427674902 4226 15991618
SGTC_996 3970-0799 1.8 µM -1.10578860733157 0.16087160358361 no 2839 0.13440901362013 4202 6615648 YGL040C HEM2
SGTC_2214 7179297 48.276 µM -1.10598943279419 0.160824102819692 no 2840 0.134365546604439 4242 769744
SGTC_359 0081-0058 15.9 µM -1.10623382967035 0.160766308568107 no 2841 0.134312661937734 4303 3494159
SGTC_20 0481-0013 4.944 µM -1.10738684421982 0.160493830028237 no 2842 0.13406335568852 4227 182045
SGTC_105 0111-0055 734.78 µM -1.10805007814052 0.160337232425833 no 2843 0.133920094547495 4210 5179370
SGTC_1386 3228-0095 33.8 µM -1.1082471489749 0.160290720852529 no 2844 0.133877546752943 4219 870181
SGTC_562 3772-2733 112 µM -1.10893127478646 0.160129325693125 no 2845 0.133729915403139 4183 2876874 YIL048W NEO1
SGTC_1139 k015-0024 46.9 µM -1.10995070712163 0.1598890240657 no 2846 0.133510134086262 4230 2766652
SGTC_812 4251-0442 148 µM -1.11065166726081 0.159723929952507 no 2847 0.133359156992096 4240 5723007
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.11101091627448 0.159639360830709 no 2848 0.133281825276165 4223 115019
SGTC_2287 7945887 168.79 µM -1.11525559474733 0.158642359934776 no 2849 0.132370454168459 4225 1245853
SGTC_983 1491-0821 12.2 µM -1.11680655399041 0.158279087313221 no 2850 0.13203852297563 4203 46495113
SGTC_585 0kpi-0023 191 µM -1.12359342018992 0.15669586231528 no 2851 0.130592774369903 4149 64601
SGTC_546 peri-Naphthalide 147 µM -1.12818081418478 0.15563164954204 no 2852 0.129621782412128 4150 223824 A penicillin ester.
SGTC_2655 perillic acid 100 µM -1.12831079698121 0.155601564923029 no 2853 0.129594342618702 4236 5702197 An apoptosis inducer.
SGTC_2703 st077852 53.4 µM -1.12876329458379 0.155496863924558 no 2854 0.129498850281816 4255 6281836
SGTC_230 MPP+ 141.667 µM -1.1304930390823 0.155097056127816 no 2855 0.129134264964264 4185 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2336 9001819 198.65 µM -1.13314823663798 0.154484663670857 no 2856 0.128576003787814 4301 2989602
SGTC_1908 st060353 56.5 µM -1.1336270983346 0.154374389785301 no 2857 0.128475500595705 4280 4227716
SGTC_538 2922-0838 53.3 µM -1.13394536345706 0.154301127417372 no 2858 0.128408733484428 4264 777039
SGTC_1746 st038117 42 µM -1.13560332233058 0.153919848979383 no 2859 0.128061308897431 4275 2898218
SGTC_1091 telmisartan 47.6 µM -1.13680879844168 0.153643019144533 no 2860 0.127809112217398 4259 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1414 3917-0015 5.4 µM -1.13802392329371 0.153364307368726 no 2861 0.127555246461999 4221 6618702
SGTC_894 0960-0238 55.9 µM -1.13888186902788 0.15316772320569 no 2862 0.127376214414148 4231 6741907 YDL195W SEC31
SGTC_1474 0330-0125 5.35 µM -1.14213050948575 0.152424864589739 no 2863 0.126699887687767 4257 X1474
SGTC_760 0568-0725 82.9 µM -1.14273627185394 0.152286611345242 no 2864 0.126574052599946 4266 3916171
SGTC_3238 9133470 49.47 µM -1.14356469750608 0.152097674433092 no 2865 0.126402104608603 4230 3534688
SGTC_521 r062-0005 13.8 µM -1.14626671225699 0.151482515164626 no 2866 0.125842405936448 4156 2832033
SGTC_564 3555-0129 330 µM -1.14633686316705 0.151466566188318 no 2867 0.125827897847503 4097 563260
SGTC_2319 6033012 152.6 µM -1.14761865368105 0.151175344647559 no 2868 0.12556301286122 4182 847246
SGTC_2225 6654152 15.4 µM -1.14905784358521 0.150848806331166 no 2869 0.125266064933652 4137 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_362 0310-0100 9.03 µM -1.14945564798401 0.150758631236354 no 2870 0.125184072550117 4302 790235
SGTC_1994 st072947 40.9 µM -1.15000893010056 0.150633271826969 no 2871 0.125070096615006 4293 5286565 YDL195W SEC31
SGTC_1689 st020265 53.493 µM -1.15043661748646 0.150536416517818 no 2872 0.124982042833918 4249 5758320 YPR016C TIF6
SGTC_2425 5628681 7.85 µM -1.15552357454823 0.149387590936537 no 2873 0.123938042200649 4315 5714958
SGTC_1873 rapamycin 2 nM -1.15577960014194 0.149329925868676 no 2874 0.123885659647172 4200 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_402 epigallocatechin gallate 10 µM -1.1581162329702 0.148804328978285 no 2875 0.123408303184612 4185 65064 An antioxidant.
SGTC_1701 st028638 40.4 µM -1.16163036123775 0.148016199417724 no 2876 0.122692821942806 4262 3490878
SGTC_962 1254-0300 21.5 µM -1.1624160285945 0.147840377065639 no 2877 0.122533257796008 4215 7340576
SGTC_2795 7780010 54.55 µM -1.16335298068869 0.147630882001297 no 2878 0.122343159088921 4222 953673
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.16355800383212 0.147585066979189 no 2879 0.122301589453053 4167 4330530
SGTC_625 k213-0058 121 µM -1.16373288084628 0.147545996019291 no 2880 0.122266139956187 4315 3655420
SGTC_2640 pentamidine 10.38 µM -1.16413972496321 0.147455125866558 no 2881 0.122183696084581 4236 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_736 0958-0254 92.6 µM -1.16456301553292 0.147360622147578 no 2882 0.122097960901247 4336 6812352
SGTC_178 4092-0806 87.505 µM -1.16675544584311 0.146871790509471 no 2883 0.121654572226153 4152 2169044
SGTC_286 k060-0067 22.9 µM -1.16712116035185 0.146790355545618 no 2884 0.121580721786266 4280 5985051
SGTC_1574 spiramycin 23.7 µM -1.16748847003827 0.146708595873653 no 2885 0.121506580946272 4220 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1066 ketoconazole 628 nM -1.16970034862556 0.146216898651277 no 2886 0.121060788905272 4326 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1798 st045719 60.953 µM -1.17393558916421 0.14527850284508 no 2887 0.120210413017333 4199 3980186
SGTC_2806 7952793 58.44 µM -1.17556639634514 0.144918250252186 no 2888 0.119884095157768 4319 2972490
SGTC_902 1120-0002 2.07 µM -1.17638567286142 0.144737495572105 no 2889 0.119720397150028 4245 3280475
SGTC_275 trichlorophene 5.69 µM -1.17752139752068 0.144487175065719 no 2890 0.119493731082103 4299 62616
SGTC_2299 7976368 114.88 µM -1.1778935867427 0.144405205835163 no 2891 0.119419516074627 4282 2979718
SGTC_1802 st050112 57.9 µM -1.17819245806452 0.144339406490049 no 2892 0.119359944298566 4265 4662563
SGTC_1960 st011366 51.8 µM -1.17911406132466 0.144136634072336 no 2893 0.119176380083033 4272 3972846
SGTC_3008 9078912 71.4286 µM -1.18051671289681 0.143828389520133 no 2894 0.118897383640912 4266 16648731
SGTC_514 4466-0038 2.65 nM -1.1821414847349 0.143471888484925 no 2895 0.11857478305948 4077 5722064
SGTC_570 0987-0065 62.6 µM -1.18258869126972 0.143373868973282 no 2896 0.118486098268929 4078 3104428
SGTC_1109 tnp00067 928.257 nM -1.18275576111149 0.143337261917183 no 2897 0.11845297895518 4271 676295
SGTC_1005 4092-0690 4.4 µM -1.18281819545081 0.143323583406129 no 2898 0.118440603880013 4288 1529343
SGTC_3147 9097027 49.47 µM -1.1842724915395 0.143005216386953 no 2899 0.118152607190087 4261 25236841
SGTC_517 1365-0151 113 µM -1.1845605659832 0.14294220935735 no 2900 0.118095618140139 4314 768657
SGTC_3146 9095609 49.47 µM -1.18461073944633 0.142931237442728 no 2901 0.118085694437055 4317 17173999
SGTC_3082 9117008 49.47 µM -1.18676377250028 0.142460949146546 no 2902 0.117660406150424 4315 41448529
SGTC_1681 tripelennamine 100 µM -1.18678241614874 0.142456881379374 no 2903 0.117656728214146 4212 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_545 4218-0007 221 µM -1.18690926870334 0.142429206121967 no 2904 0.117631705465303 4261 2840508
SGTC_2419 paclitaxel 166.5 µM -1.18708511315009 0.142390848382251 no 2905 0.117597024878209 4191 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_785 1270-0111 65.3 µM -1.18748597166762 0.142303433436311 no 2906 0.117517993376337 4199 6741994
SGTC_1695 st026914 34.495 µM -1.18921512707475 0.141926773863882 no 2907 0.117177511680183 4264 3289191
SGTC_2110 5483698 200 µM -1.18923974434418 0.141921416395456 no 2908 0.117172669433875 4257 2848765 YHR062C RPP1
SGTC_2464 5717415 7.67 µM -1.18947131660205 0.141871025913772 no 2909 0.117127125832794 4248 5285744
SGTC_2064 5220758 200 µM -1.19021137132982 0.141710070091733 no 2910 0.116981662447965 4334 788518
SGTC_3051 9093778 49.47 µM -1.19035238106748 0.141679415667069 no 2911 0.116953960438784 4342 17217378
SGTC_759 3486-0358 89.3 µM -1.19210791761082 0.141298151686652 no 2912 0.116609466430386 4274 875103
SGTC_1725 st036284 20.55 µM -1.1922262486381 0.141272477829473 no 2913 0.116586271904379 4332 707914
SGTC_1238 0333-0287 48.8 µM -1.19625360343043 0.140400562302538 no 2914 0.115798804235299 4261 7226
SGTC_2459 5811157 9.22 µM -1.19800056722285 0.140023486238517 no 2915 0.115458398080708 4241 2870684 YBR192W RIM2
SGTC_3264 9137442 49.47 µM -1.19824694622509 0.139970361606838 no 2916 0.115410446958271 4265 17015726
SGTC_1395 3486-0190 4.35 µM -1.19889661273569 0.139830345163689 no 2917 0.115284074509446 4268 6748079
SGTC_146 3448-8650 53.125 µM -1.20056976157397 0.139470185755256 no 2918 0.11495906828971 4261 2891488 YIL048W NEO1
SGTC_309 k408-0051 1.48 µM -1.20059314935427 0.139465155813916 no 2919 0.114954529877454 4196 3640463
SGTC_1294 1000-1494 117 µM -1.20147183445419 0.139276268984389 no 2920 0.114784112848748 4282 712797 YDL207W GLE1
SGTC_1347 1493-0251 600 nM -1.20180248748509 0.139205235144773 no 2921 0.114720030746034 4330 3986378
SGTC_3031 9088762 49.47 µM -1.20234078751202 0.139089645469973 no 2922 0.114615760146677 4252 205253
SGTC_1707 st032323 6.317 µM -1.20398347040199 0.138737314576773 no 2923 0.114297983726106 4143 3132057 YMR211W DML1
SGTC_2589 lobaric acid 100 µM -1.20470834156113 0.1385820340383 no 2924 0.114157957340486 4262 73157 A novel microtubule depolymerizer.
SGTC_804 1595-0054 20.9 µM -1.20555823264765 0.138400122824108 no 2925 0.113993935996054 4242 761523 Stimulates phospholipase C.
SGTC_2903 5923464 63.88 µM -1.20913321431667 0.13763671409418 no 2926 0.113305835298405 4298 2876576
SGTC_1304 1165-0502 251 µM -1.20996922098087 0.137458606981644 no 2927 0.113145351821313 4273 767425
SGTC_2222 6885208 172.143 µM -1.21019164433553 0.137411247292539 no 2928 0.113102681795174 4271 609514
SGTC_2223 6903751 107.57 µM -1.21032755322114 0.137382314257581 no 2929 0.113076614485628 4254 5598863
SGTC_2762 leflunomide 42.06 µM -1.21035347311205 0.137376796760271 no 2930 0.113071643540192 4266 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3081 9117243 49.47 µM -1.21227247403565 0.136968724464964 no 2931 0.112704048478741 4270 45595589
SGTC_691 1548-0686 185 µM -1.21263130810586 0.136892511031149 no 2932 0.112635406673366 4271 46495133
SGTC_2596 sinensetin 100 µM -1.21280950063185 0.136854675162228 no 2933 0.11260133110524 4314 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_823 0417-1665 178 µM -1.2158202073252 0.136216488122779 no 2934 0.112026709655471 4297 3429856
SGTC_1007 4101-0031 70 µM -1.22046914536641 0.135235046867745 no 2935 0.111143539599838 4270 1146276
SGTC_252 miconazole 1.30953 nM -1.22405214157895 0.13448195318034 no 2936 0.110466279190436 4203 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1614 st002383 48.6 µM -1.22405241954926 0.134481894866937 no 2937 0.110466226763329 4334 1947235
SGTC_2761 levamisole 97.89 µM -1.2252878303588 0.134222898335356 no 2938 0.110233395994844 4318 26879 An alkaline phosphatase inhibitor.
SGTC_2161 5662504 8.5105 µM -1.2257157759316 0.13413326203507 no 2939 0.110152825689868 4274 2859334
SGTC_994 3910-0338 138 µM -1.22674539824478 0.133917768701097 no 2940 0.109959149412788 4372 3479481
SGTC_2496 diffractaic acid 79.83 µM -1.22682229535275 0.133901684184081 no 2941 0.109944694556525 4323 94870 An apoptosis inducer which activates caspases.
SGTC_3141 9094609 49.47 µM -1.22711755267383 0.133839937742424 no 2942 0.109889205760753 4266 25236309 YDL196W YDL196W
SGTC_3057 9095946 49.47 µM -1.22830330622242 0.133592161136703 no 2943 0.109666565162415 4359 24540043
SGTC_411 enrofloxacin 100 µM -1.23184582212966 0.132853792051522 no 2944 0.109003341368695 4373 71188 A bacterial gyrase inhibitor.
SGTC_1130 3454-2858 15.9 µM -1.23642955336633 0.131902579011813 no 2945 0.1081494682289 4309 715628 YIL048W NEO1
SGTC_1121 fusaric acid 630.51 nM -1.23764891690338 0.131650330489686 no 2946 0.10792313400454 4282 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1102 cgs 12066b 26.1 µM -1.2394249582897 0.131283518473426 no 2947 0.107594081643411 4325 6438352 A 5-HT1B full agonist.
SGTC_2168 5727979 200 µM -1.24006363891503 0.13115178224126 no 2948 0.107475928331041 4236 695210
SGTC_2757 clomiphene 4.22 µM -1.24334887390624 0.13047560250918 no 2949 0.106869650735383 4346 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2499 avocadenofuran 51.48 µM -1.24450780273591 0.130237643607373 no 2950 0.106656364716463 4278 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2413 inermin 26.06 µM -1.24655754815288 0.12981751192503 no 2951 0.106279887843827 4384 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.24680261833619 0.129767343323352 no 2952 0.106234940103662 4319 5379071
SGTC_1222 0366-0074 1.18 µM -1.24782802928795 0.129557575878733 no 2953 0.106047020830525 4343 286520
SGTC_740 k014-0057 261 µM -1.24866912405441 0.129385689292576 no 2954 0.105893059177456 4319 4012779
SGTC_1690 st023502 41.2 µM -1.25025416398978 0.129062199325303 no 2955 0.105603358220683 4329 24207482
SGTC_1435 4092-0789 56.7 µM -1.25081718021437 0.128947428733263 no 2956 0.105500592670031 4312 2248285
SGTC_3249 9135183 49.47 µM -1.25370990977317 0.128358863375627 no 2957 0.104973732336735 4305 4902779
SGTC_1530 rhein 70.4 µM -1.25380500283582 0.128339547108087 no 2958 0.104956445184048 4385 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2998 9066762 71.4286 µM -1.2539603249335 0.128308000848584 no 2959 0.104928213310418 4372 4945196
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.25500209155409 0.128096554915599 no 2960 0.104739000347906 4326 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_12 0849-0099 9.267 µM -1.25660282947563 0.127772127246317 no 2961 0.104448744832878 4258 6071388
SGTC_3263 9137018 49.47 µM -1.26087609617693 0.126908846657389 no 2962 0.103676745841908 4291 43844957
SGTC_1826 st055655 41.6 µM -1.26108520197306 0.126866707788071 no 2963 0.103639075778887 4353 676168
SGTC_2858 9025781 8.96 µM -1.26377688173895 0.126325151750072 no 2964 0.103155060582215 4203 4894980 YPL153C RAD53
SGTC_2760 etidronate 98.04 µM -1.26440620963397 0.126198765994871 no 2965 0.103042132612949 4296 3305 A chelator and antioxidant.
SGTC_2695 st077686 51.995 µM -1.26442292951198 0.126195409401614 no 2966 0.103039133586627 4335 2876092
SGTC_2517 totarol 10 µM -1.26460155192944 0.126159554004162 no 2967 0.103007098234647 4331 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2485 5633444 17.78 µM -1.26513083721142 0.126053350728572 no 2968 0.102912215116329 4339 5724239
SGTC_770 0389-1121 67.2 µM -1.26598606365672 0.125881877770925 no 2969 0.102759035886656 4412 6753108
SGTC_1506 4226-2149 212 µM -1.27113692954454 0.124852569289782 no 2970 0.101839969720225 4345 991114
SGTC_2701 st077767 14.721 µM -1.2716413615262 0.124752084640039 no 2971 0.101750286893261 4319 5721188
SGTC_2150 5556613 200 µM -1.27236899908529 0.124607236227311 no 2972 0.101621021712796 4368 743190
SGTC_189 3970-0742 2.116 µM -1.27400865709583 0.124281265959827 no 2973 0.101330174057349 4327 2891807
SGTC_2343 7990716 14.84 µM -1.27628324633309 0.12383005724472 no 2974 0.100927705183147 4354 6456862
SGTC_2164 5685496 200 µM -1.27923483895403 0.123246263029777 no 2975 0.10040718545685 4269 759046
SGTC_186 3455-3465 67.277 µM -1.28277292375026 0.12254901179444 no 2976 0.099785821388982 4360 755278
SGTC_6 0844-0013 19.835 µM -1.28298650904226 0.122507009248127 no 2977 0.0997484013062522 4488 1584900
SGTC_113 0099-0221 2.5 µM -1.28357299494168 0.122391726008108 no 2978 0.0996457018686277 4317 89219
SGTC_149 3970-0822 46.1 µM -1.28407178547474 0.122293740632558 no 2979 0.0995584195642833 4337 3114250 YBL034C STU1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.29076246218213 0.120984705589801 no 2980 0.0983930289887503 4335 6312947
SGTC_2354 9060492 162 µM -1.29087907024747 0.120961978896348 no 2981 0.0983728069955494 4386 6471895
SGTC_325 2810-4341 181 µM -1.29092674062541 0.120952688894086 no 2982 0.0983645409476676 4362 774970
SGTC_3115 9123671 49.47 µM -1.29252708273652 0.120641105545008 no 2983 0.0980873365766157 4504 3286988
SGTC_603 3794-0023 45.9 µM -1.29331043765708 0.12048879411985 no 2984 0.0979518560520316 4387 3802260
SGTC_215 1287-0124 461.5 µM -1.29378472780037 0.120396641474122 no 2985 0.0978698946811232 4372 5560863
SGTC_320 4092-0846 5.34 µM -1.29426366643575 0.120303636031631 no 2986 0.0977871810312554 4315 1359356
SGTC_782 0083-0095 30.5 µM -1.29471235929411 0.120216549968709 no 2987 0.0977097373900699 4315 3591729 An indicator and reagent.
SGTC_1626 st003712 1.76 µM -1.29775057400821 0.119628036407673 no 2988 0.0971865293968218 4392 24207035
SGTC_1056 3448-1962 115 µM -1.29909900879454 0.11936749167524 no 2989 0.0969549766187541 4335 715507
SGTC_3167 9103034 49.47 µM -1.30176254846118 0.118854019461011 no 2990 0.0964987850697084 4448 5127859
SGTC_1233 0325-0408 14.2 µM -1.30224832756473 0.118760540329832 no 2991 0.0964157547038618 4405 12874
SGTC_3355 9151058 44.0485 µM -1.30246074211013 0.118719681435618 no 2992 0.0963794648726874 4384 17015728
SGTC_1143 3454-2408 5.08 µM -1.30716691747648 0.117816973869816 no 2993 0.0955780142348524 4378 X1143
SGTC_811 0416-0114 265 µM -1.30765122987188 0.117724352634146 no 2994 0.0954958161194919 4401 6612453
SGTC_3327 9140648 26.9345 µM -1.30852536577 0.117557310946155 no 2995 0.0953475883838544 4402 8029710
SGTC_1147 3809-1045 12.3 µM -1.30886321802203 0.117492794557328 no 2996 0.0952903439867134 4355 325925
SGTC_1812 st052057 4.327 µM -1.31029884542949 0.117218926226245 no 2997 0.0950473789528908 4388 3645418
SGTC_647 0140-0236 81 µM -1.31601507594366 0.116132951770341 no 2998 0.0940844913230067 4387 990837
SGTC_3310 9130229 44.1445 µM -1.31816484609904 0.115726390046183 no 2999 0.0937242353422251 4404 7761258
SGTC_2375 9072683 200 µM -1.31978439428919 0.115420771588302 no 3000 0.0934535066949597 4432 16798029
SGTC_1567 st069303 68.4 µM -1.32109137584887 0.115174554863584 no 3001 0.0932354491446518 4405 5581319
SGTC_3143 9086658 49.47 µM -1.32224843749651 0.114956892737792 no 3002 0.0930427182581429 4395 25236626
SGTC_76 0433-0009 400.328 µM -1.32385491310006 0.114655173856158 no 3003 0.0927756173094092 4448 2841569
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.32504990438884 0.114431103353615 no 3004 0.0925772999456499 4394 551469
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.32602732306439 0.114248061376654 no 3005 0.0924153236047532 4385 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2987 9018338 71.43 µM -1.33121552591217 0.11327995305587 no 3006 0.0915590520828459 4394 5055682
SGTC_2340 7987427 183.45 µM -1.33292233655884 0.11296274852648 no 3007 0.0912786458085601 4406 2239331
SGTC_1295 1013-0063 9.78 µM -1.33649155165701 0.112301473158473 no 3008 0.0906943300270783 4423 6826038
SGTC_2395 5646831 180.19 µM -1.33953507762541 0.111739782142754 no 3009 0.0901982714905061 4388 6808628
SGTC_559 1550-0661 158 µM -1.34198780649815 0.111288588833105 no 3010 0.0897999746515664 4446 5830875
SGTC_2853 9015042 58.44 µM -1.34512500644425 0.110713386201679 no 3011 0.0892924344958012 4317 6457456
SGTC_3099 9120367 49.47 µM -1.34521914996608 0.11069615806329 no 3012 0.0892772368892322 4427 24824940
SGTC_2134 5324836 1.464 µM -1.34539475450009 0.110664027802952 no 3013 0.0892488941589188 4374 699272
SGTC_89 0302-0250 142.109 µM -1.34624169523215 0.110509157398441 no 3014 0.0891122911653018 4476 4203518 YLR208W SEC13
SGTC_980 1473-0395 201 µM -1.34752856201184 0.110274140216548 no 3015 0.0889050304617956 4291 768876
SGTC_3163 9099914 49.47 µM -1.34899353079981 0.110007033262745 no 3016 0.0886695220029717 4468 16268368
SGTC_1646 st011709 75.6 µM -1.34945223896893 0.109923492766608 no 3017 0.0885958756599525 4357 5757843
SGTC_2281 7943571 200 µM -1.35142635398562 0.109564484085695 no 3018 0.0882794482262466 4486 1244024
SGTC_460 trequinsin 123 µM -1.35660618777075 0.108626494506758 no 3019 0.0874531873004197 4491 5537 A vasodilator.
SGTC_1621 st003705 32.4 µM -1.35826230928272 0.108327818009293 no 3020 0.0871902326980803 4399 24207032
SGTC_204 PMA1.184 62.41 µM -1.35856106559365 0.108274001195843 no 3021 0.0871428598830721 4376 2252213 YGL008C PMA1
SGTC_618 k072-0232 33.2 µM -1.36267380251619 0.107535103517039 no 3022 0.0864926688806616 4452 5872756 YGL099W LSG1
SGTC_908 3448-7491 47.7 µM -1.36476052946081 0.107161593106029 no 3023 0.0861641640869398 4421 1203031
SGTC_1213 1315-0166 115 µM -1.36876442835028 0.106447543002014 no 3024 0.085536461731706 4422 768401
SGTC_2470 5664817 21.68 µM -1.37047471167728 0.106143582712091 no 3025 0.0852693820587865 4460 2859561
SGTC_2001 4023502 57.655 µM -1.37301160559487 0.105693868575022 no 3026 0.0848743694042442 4421 108941 YCR052W RSC6
SGTC_1045 1348-1485 165 µM -1.37354847712462 0.105598874448807 no 3027 0.0847909508072239 4386 6810614
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.37665906655338 0.105049701235137 no 3028 0.0843088399178867 4396 364106
SGTC_1226 3909-7979 35.4 µM -1.37713650208804 0.104965593525603 no 3029 0.0842350245559756 4407 6615510
SGTC_1235 benzylparaben 21.5 µM -1.37762415166812 0.104879736787737 no 3030 0.0841596801058651 4449 7180
SGTC_1195 1502-0147 41.1 µM -1.38009803935624 0.104444961473164 no 3031 0.0837782304450623 4412 817940
SGTC_1949 st076024 69.1 µM -1.38061681133379 0.104353955365451 no 3032 0.0836984057751776 4374 2921930
SGTC_375 3970-0961 9.27 µM -1.38112688234417 0.104264531674748 no 3033 0.0836199756659423 4385 2898222
SGTC_2875 9039966 71.43 µM -1.3851980877772 0.103552773803514 no 3034 0.0829959526344339 4415 6463691
SGTC_2231 micatex 6.853 µM -1.38599913285682 0.103413145381419 no 3035 0.0828735841371777 4453 20737 An antifungal of unknown mechanism.
SGTC_1578 josamycin 24.2 µM -1.39114438163889 0.102519545407307 no 3036 0.0820908244551991 4414 5282165 A P450 substrate.
SGTC_2159 5658611 73.75 µM -1.39134524020132 0.102484775549037 no 3037 0.0820603806845373 4410 793844
SGTC_2111 5486399 200 µM -1.39358055288976 0.10209840762212 no 3038 0.0817221522172851 4394 689674
SGTC_2456 5770359 74.46 µM -1.39626084769044 0.101636524263525 no 3039 0.0813179796483583 4429 3118787
SGTC_1876 myriocin 605 nM -1.39668318232481 0.101563884180053 no 3040 0.0812544318468903 4421 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2969 9091408 28.7 µM -1.40005779404172 0.100984820348439 no 3041 0.0807480062284488 4367 4286311
SGTC_1781 st038725 66.3 µM -1.40636683342984 0.0999086885340037 no 3042 0.079807611808745 4431 4270275 YIL048W NEO1
SGTC_2441 5730946 39.09 µM -1.4070945824833 0.0997850973150827 no 3043 0.0796996721745709 4492 1774275
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.40823564520211 0.0995915393042369 no 3044 0.0795306523014718 4358 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2229 7354935 190 µM -1.4129282409135 0.0987984202724286 no 3045 0.0788384122222188 4399 318112
SGTC_1963 st076565 50.3 µM -1.41330933011248 0.0987342139831559 no 3046 0.078782395929623 4464 4914280
SGTC_138 0850-0259 40.9225 µM -1.41356459380228 0.0986912239826409 no 3047 0.0787448915942853 4378 6813004
SGTC_1951 sophoraflavanone G 9.2 µM -1.41388076491209 0.098637995310273 no 3048 0.0786984572614387 4394 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3134 9127454 49.47 µM -1.41639701432963 0.0982151235912386 no 3049 0.0783296487986224 4495 24262820
SGTC_3229 9132204 49.47 µM -1.41764415947751 0.0980060257961599 no 3050 0.0781473403187155 4538 17682924
SGTC_2904 7225135 42.03 µM -1.42275886989105 0.097151899487809 no 3051 0.0774030341511064 4508 4446116
SGTC_2273 7815444 169.05 µM -1.42406747548844 0.0969342503546439 no 3052 0.0772134702020313 4390 2824616
SGTC_99 0109-0120 622.8 µM -1.42755558233985 0.0963558526669047 no 3053 0.0767099080467292 4465 759414
SGTC_1970 st070122 35.8 µM -1.42924378119044 0.0960768281811431 no 3054 0.0764670890647536 4460 102928
SGTC_195 4234-0266 16.654 µM -1.43048629120018 0.0958718467226262 no 3055 0.0762887487978712 4471 2303354
SGTC_1693 xanthone 101.9 µM -1.43415435836953 0.0952685888967973 no 3056 0.0757641092531147 4488 7020 An insecticide.
SGTC_1765 st044815 90.4 µM -1.43498381500699 0.0951325630608537 no 3057 0.0756458548694745 4477 645695
SGTC_881 0833-0569 170 µM -1.43647184826013 0.0948888932396569 no 3058 0.0754340606958084 4480 5418700
SGTC_1870 st057514 26.5 µM -1.43684446971977 0.0948279474355225 no 3059 0.0753810957025437 4465 5393161
SGTC_97 0535-0701 19.132 µM -1.43924341761179 0.0944362670431416 no 3060 0.0750407839649473 4353 2832013 YGL099W LSG1
SGTC_1654 st012436 41.8 µM -1.44150980616794 0.0940673269132497 no 3061 0.0747203544904054 4456 4323132
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.44543779377983 0.0934304195983339 no 3062 0.074167477037124 4433 16623 A steroid.
SGTC_1568 digitonin 820 nM -1.44747120613723 0.0931019639416061 no 3063 0.0738824976163719 4435 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1990 st072050 59.8 µM -1.4485143962131 0.0929337897650863 no 3064 0.0737366213723801 4457 17233948
SGTC_2122 5258151 111.688 µM -1.44958297081348 0.0927617562671896 no 3065 0.0735874238076129 4471 2173356
SGTC_508 roscovitine 141 µM -1.44962541560279 0.0927549278009224 no 3066 0.0735815023095693 4530 160355 A CDKinase inhibitor.
SGTC_1700 st030840 7.9285 µM -1.4503608963585 0.0926366635698921 no 3067 0.073478952790967 4510 5499307
SGTC_283 0987-0079 11.7 µM -1.45076923595665 0.0925710513301626 no 3068 0.0734220644085131 4470 411556
SGTC_1647 st011722 22.4 µM -1.456902527231 0.0915896829937469 no 3069 0.0725716441709444 4444 2854783
SGTC_2038 4100038 30.985 µM -1.46251651188789 0.0906981844190366 no 3070 0.0717998614700641 4440 3596803
SGTC_707 0865-0008 204 µM -1.4700108945738 0.089518138195958 no 3071 0.0707794016814337 4517 723043
SGTC_2880 9042983 58.44 µM -1.47247263084092 0.089133021607852 no 3072 0.0704466462505706 4426 6464714
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.47409843835972 0.0888793554876601 no 3073 0.0702275444710632 4435 97141
SGTC_820 1582-0060 59.9 µM -1.47610416184056 0.0885671541318902 no 3074 0.0699579659101322 4505 3848840
SGTC_2258 7960471 200 µM -1.47806451748553 0.0882628046470941 no 3075 0.0696952551199341 4474 2974708
SGTC_1462 k081-0014 26.5 µM -1.48209469156325 0.0876395610037979 no 3076 0.069157550538515 3918 3270634
SGTC_2756 carbadox 75.1 µM -1.49488349326354 0.0856835880319786 no 3077 0.0674724254755568 4423 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1358 1509-0022 2.48 µM -1.49522557332766 0.0856317213568645 no 3078 0.0674277907453874 4527 3258434
SGTC_2896 9052656 71.43 µM -1.49559095937432 0.085576346963117 no 3079 0.0673801402517889 4191 6469436
SGTC_2702 st077768 96.8 µM -1.49742012413554 0.085299539398149 no 3080 0.0671419875794659 4459 6484119
SGTC_162 k030-0015 37.8 µM -1.49791402069022 0.0852249131524405 no 3081 0.0670777952168459 4545 1809920 YMR134W ERG29
SGTC_1314 1222-0010 41.1 µM -1.50092436759994 0.0847711164420344 no 3082 0.0666875623787493 4499 3526027
SGTC_3035 9091303 49.47 µM -1.50148948947814 0.0846861291449023 no 3083 0.0666145015924381 4570 25237002
SGTC_3347 9188721 44.724 µM -1.50183204404986 0.0846346443160965 no 3084 0.0665702451956044 4502 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1524 corynanthine 62.1 µM -1.50208537851772 0.0845965840795452 no 3085 0.0665375302473066 4561 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_673 1082-0474 110 µM -1.50231961477751 0.0845614045266596 no 3086 0.0665072926660743 4480 3098046
SGTC_2705 st078069 42.8 µM -1.50728827237332 0.0838177531200979 no 3087 0.0658683911667631 4504 1530061
SGTC_2883 9059145 45.46 µM -1.5094799482993 0.0834912938908653 no 3088 0.0655880878746634 4487 16476510
SGTC_1391 3442-0225 151 µM -1.51037339673812 0.083358485549539 no 3089 0.0654740864600593 4468 5227075
SGTC_2334 9017922 200 µM -1.51073094013432 0.0833053823448168 no 3090 0.0654285080432182 4522 3163164
SGTC_906 1165-0455 526 µM -1.51226016215354 0.0830785455829694 no 3091 0.0652338456789992 4485 3252859
SGTC_539 4859-0462 2.54 µM -1.51332065108418 0.0829215112048422 no 3092 0.0650991147789591 4530 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3123 9126162 49.47 µM -1.51549100499551 0.0826008272418519 no 3093 0.0648240532702555 4506 25239884
SGTC_2371 9071574 200 µM -1.51561749503181 0.0825821663403117 no 3094 0.0648080503268853 4503 45596039
SGTC_2224 6650123 117.647 µM -1.51803550875357 0.0822260499624346 no 3095 0.0645027236817295 4534 2908370
SGTC_1995 st072814 61.1 µM -1.51889286408877 0.082100059895968 no 3096 0.0643947327537315 4503 5769371
SGTC_3268 9137683 49.47 µM -1.52199308301633 0.0816456901799297 no 3097 0.0640054069308564 4575 1953228
SGTC_2216 7189485 200 µM -1.52338133574755 0.0814428427546994 no 3098 0.0638316643798933 4522 731273
SGTC_2256 7954252 200 µM -1.52387155209645 0.0813713046568312 no 3099 0.0637704005552908 4505 2972920
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.52487610075043 0.081224857275846 no 3100 0.0636450019682882 4579 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_447 ml7 120 µM -1.52647228167504 0.0809925683743999 no 3101 0.0634461441930843 4564 4216 Selective myosin light chain kinase inhibitor.
SGTC_181 1447-1644 8.07 µM -1.53534242740437 0.0797108415023294 no 3102 0.0623498687941969 4466 534600
SGTC_610 4215-0184 155 µM -1.53558573288445 0.0796759015851241 no 3103 0.0623200077645817 4524 5605015
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.53601256366093 0.0796146344860029 no 3104 0.0622676495107153 4504 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1387 3342-1166 1.8 µM -1.53676309060965 0.079506990635335 no 3105 0.0621756674763676 4502 3418228
SGTC_2597 laccaic acid a 100 µM -1.53698217459561 0.0794755894304709 no 3106 0.062148837282802 4492 5491415 A textile dye.
SGTC_187 1488-2104 32.728 µM -1.54039795372419 0.0789872205599449 no 3107 0.0617316899523773 4504 2852859
SGTC_2081 5214970 32.255 µM -1.5453901633173 0.0782775558105133 no 3108 0.0611259590951551 4454 2063512
SGTC_1641 st009299 47.1 µM -1.55345974355587 0.0771406692062569 no 3109 0.0601566697501464 4462 4046054
SGTC_1653 st012112 65 µM -1.55455491490361 0.076987347395552 no 3110 0.0600260542022085 4504 720429
SGTC_2480 5767542 37.17 µM -1.55462914754706 0.0769769633609902 no 3111 0.06001720889316 4450 2867358
SGTC_2429 5902844 64.44 µM -1.55570171529976 0.076827045992661 no 3112 0.0598895192576775 4504 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2561 acetosyringone 100 µM -1.55650202179905 0.0767153284287097 no 3113 0.0597943811338693 4473 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2516 gossypol 71.55 µM -1.55713411013898 0.076627180369914 no 3114 0.0597193240150458 4540 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2722 naftopidil 47.16 µM -1.5603525338016 0.0761795484458054 no 3115 0.0593382976071284 4461 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2921 7974240 10.71 µM -1.56559579632966 0.075454559813487 no 3116 0.0587216373702275 4584 2979074 YDR527W RBA50
SGTC_2979 9012552 45.46 µM -1.56905437209423 0.0749792266488176 no 3117 0.0583176351443671 4549 17100905
SGTC_159 3970-0959 50 µM -1.57005778534387 0.0748417497693864 no 3118 0.0582008342061819 4547 6615653
SGTC_951 1171-0579 82.7 µM -1.57031019142511 0.0748071980958376 no 3119 0.0581714821730433 4476 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1706 st031321 9.9705 µM -1.57209668385654 0.0745629943428598 no 3120 0.0579640652306754 4558 6103185
SGTC_955 1216-0110 33 µM -1.57362053544084 0.0743551734353911 no 3121 0.0577876014137149 4503 3619719
SGTC_2369 9071472 200 µM -1.57425864328371 0.0742682806072336 no 3122 0.0577138333513865 4547 17296037
SGTC_2249 haloperidol 116.36 µM -1.57497721061534 0.0741705242528655 no 3123 0.0576308524810636 4476 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1815 st051655 58.2 µM -1.57563141559017 0.0740816094721871 no 3124 0.0575553858660438 4489 5984156
SGTC_1783 st039459 87.517 µM -1.57979152803741 0.0735181014061128 no 3125 0.0570773082098385 4587 729761
SGTC_1416 3966-0321 25.3 µM -1.58211270127251 0.0732051146814331 no 3126 0.0568119222945859 4584 582530 YLR208W SEC13
SGTC_2750 bromebric acid 70.15 µM -1.59019282960969 0.0721235389946475 no 3127 0.0558956731427136 4534 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2294 7971431 200 µM -1.59649279311471 0.0712887812622007 no 3128 0.0551894067637102 4528 5741572
SGTC_1655 st012546 55.1 µM -1.59658094181009 0.0712771542226922 no 3129 0.0551795749680257 4535 720985 YLR208W SEC13
SGTC_510 ag-490 170 µM -1.59798374162514 0.0710923171897919 no 3130 0.0550232977387438 4666 5328779
SGTC_1122 capsaicin 818.572 nM -1.59869243213387 0.0709990781009197 no 3131 0.0549444799992067 4579 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3016 9080866 49.47 µM -1.59884603895098 0.0709788811621913 no 3132 0.0549274082306761 4519 17066299
SGTC_1864 st057645 30.4 µM -1.60049727671538 0.0707620473443509 no 3133 0.054744155290845 4578 688666
SGTC_2966 9084041 48.03 µM -1.60344617694174 0.0703760763823558 no 3134 0.0544180915446435 4498 17741380
SGTC_1464 k208-0027 110 µM -1.60514137877101 0.0701549313973159 no 3135 0.0542313473983373 4535 X1464
SGTC_1028 k015-0029 4.8 µM -1.6069027194323 0.0699257249784868 no 3136 0.0540378548895846 4526 4588309
SGTC_774 k060-0086 136 µM -1.61561005658383 0.0688010804492896 no 3137 0.0530893241142833 4552 5911235
SGTC_2992 9074591 71.4286 µM -1.61567235310191 0.0687930847425146 no 3138 0.0530825857396047 4487 17741321
SGTC_540 1187-0821 17.3 µM -1.61569012673016 0.0687908036433396 no 3139 0.0530806633589694 4480 847520
SGTC_703 3875-0075 71.8 µM -1.6191381667549 0.0683493781369466 no 3140 0.0527087692181404 4591 2850814
SGTC_904 1141-0088 396 µM -1.61948721510311 0.0683048143246391 no 3141 0.0526712375475474 4564 1378119
SGTC_1209 2323-2347 50.3 µM -1.62027766821605 0.0682039782271364 no 3142 0.052586321907945 4570 5412760
SGTC_2785 7756463 72.73 µM -1.62697623642672 0.067354065600634 no 3143 0.0518710724541492 4520 2201551
SGTC_1324 1418-0026 34.4 µM -1.62979252749542 0.0669991893103744 no 3144 0.0515726768194132 4576 1372513
SGTC_2961 9083290 32.55 µM -1.6315552940891 0.0667778029200172 no 3145 0.0513866012716526 4530 17741490
SGTC_1206 3978-0017 132 µM -1.63376157804556 0.066501513121524 no 3146 0.0511544614355829 4576 3873677
SGTC_1836 st055642 81 µM -1.63793157357975 0.0659817284424766 no 3147 0.0507179843338208 4547 8571
SGTC_1914 st062367 72.6 µM -1.65238010766518 0.0642050615415974 no 3148 0.0492285440474333 4540 978205
SGTC_1412 3909-8563 178 µM -1.65675140451338 0.0636749360090653 no 3149 0.0487848727641479 4645 23767530
SGTC_2495 cafestol 54.53 µM -1.66314817425323 0.0629053185941607 no 3150 0.0481413893695737 4571 16667697 An anti-infammatory.
SGTC_140 0062-0056 502.533 µM -1.66379726342811 0.062827631178003 no 3151 0.0480764755287102 4483 3758964
SGTC_2026 5148700 152 µM -1.6687210290962 0.0622407534386656 no 3152 0.047586339782212 4554 79838
SGTC_1819 st053448 58.6 µM -1.68208578855143 0.0606693167761303 no 3153 0.0462761028633489 4525 2857616
SGTC_2301 7769476 200 µM -1.68386795687864 0.0604621343059714 no 3154 0.0461035951077369 4573 977820
SGTC_70 0141-0289 43.283 µM -1.68573195326954 0.0602460318208316 no 3155 0.045923719715163 4539 352408
SGTC_427 1354-0053 47.3 µM -1.68631365788022 0.0601787158008158 no 3156 0.0458677008887934 4589 6813657
SGTC_2145 5634607 200 µM -1.68870936208389 0.0599021005679697 no 3157 0.0456375703154833 4591 308662
SGTC_413 propylparaben 100 µM -1.68924628149601 0.0598402430528201 no 3158 0.0455861215503591 4567 7175 A pharmaceutical preservative.
SGTC_3023 9089636 49.47 µM -1.69433484244691 0.0592564806129803 no 3159 0.045100836635488 4656 17249241
SGTC_227 fluconazole 33.516 µM -1.69992071572744 0.0586208178898504 no 3160 0.0445729198737559 4580 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2364 9055074 200 µM -1.70474840598466 0.0580757586317324 no 3161 0.0441206788590893 4590 6470630
SGTC_2022 5136654 200 µM -1.70537029538181 0.0580058361353105 no 3162 0.0440626923685488 4573 1713771
SGTC_1747 st037496 66.6 µM -1.71041608788135 0.0574409530643496 no 3163 0.0435944790832698 4549 723305
SGTC_2907 7721985 69.9 µM -1.7155577481808 0.056869798439968 no 3164 0.0431215086731835 4591 3267881
SGTC_104 0074-0074 590.992 µM -1.71595351886641 0.056826020811621 no 3165 0.0430852750411477 4485 3943124
SGTC_132 0417-1715 25.805 µM -1.71659304804438 0.0567553362740312 no 3166 0.0430267767961118 4561 6769098
SGTC_1146 3579-1023 7 µM -1.71878309032956 0.0565138044224538 no 3167 0.0428269378373514 4623 X1146
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.71913457734308 0.0564751157312207 no 3168 0.0427949350019452 4531 17037758
SGTC_1058 3448-5425 97.3 µM -1.72022996759983 0.0563546783926522 no 3169 0.0426953238641955 4543 7279705
SGTC_1113 artemisinin 1.17947 µM -1.72182734009966 0.056179411470207 no 3170 0.0425504001880466 4620 2240 An anti-malaria and mitochondrial poison.
SGTC_2092 5303694 80.6725 µM -1.73344788631894 0.0549172865772948 no 3171 0.0415080462789485 4612 1963699
SGTC_1242 0402-0103 60.1 µM -1.73501876506806 0.0547484040676066 no 3172 0.0413687407579575 4533 432868
SGTC_2108 5365811 200 µM -1.73665995338829 0.0545724015088143 no 3173 0.0412236051698136 4609 780283
SGTC_3290 9121031 71.43 µM -1.73983278463682 0.0542334130101214 no 3174 0.0409441919665111 4610 17014854
SGTC_201 4262-0159 12.803 µM -1.74003657262242 0.0542116971690401 no 3175 0.0409262981484318 4652 1341029
SGTC_1898 st060199 18.6 µM -1.74031447825181 0.0541820943716833 no 3176 0.0409019065770587 4607 688866
SGTC_2755 lomerizine 42.69 µM -1.74353153150341 0.0538403408846046 no 3177 0.0406204057046085 4547 3949 A calcium channel blocker.
SGTC_2314 7727897 200 µM -1.74749139287328 0.0534220236248058 no 3178 0.0402760683124751 4576 900724
SGTC_2091 4-phenylthiadiazole 200 µM -1.7492542162632 0.0532366304913833 no 3179 0.0401235430858696 4619 270010
SGTC_1418 3966-3099 2.4 µM -1.74966242439665 0.0531937727458689 no 3180 0.0400882905858547 4625 740335
SGTC_3223 9129970 49.47 µM -1.75540791369989 0.0525934514875853 no 3181 0.0395947797018204 4618 17248386
SGTC_776 4476-4378 112 µM -1.76044858985306 0.0520712123985297 no 3182 0.0391658884819601 4635 2892008
SGTC_1814 st052110 31.539 µM -1.76045302572074 0.0520707546415073 no 3183 0.03916551272353 4555 674163
SGTC_2174 5790901 200 µM -1.76366977016699 0.0517396452118404 no 3184 0.0388937967584167 4586 786020
SGTC_218 alverine citrate 93.75 µM -1.76431854556981 0.0516730680038588 no 3185 0.0388391816585091 4655 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_905 2-aminofluorene 215 µM -1.77135348337832 0.0509555091697964 no 3186 0.0382509693854133 4630 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1678 st019265 80.2 µM -1.77465520991443 0.0506214814275376 no 3187 0.0379774175754037 4597 5367020
SGTC_1394 3474-0001 65.7 µM -1.77666519717438 0.0504189913994884 no 3188 0.0378116708433608 4612 5017666 YIL048W NEO1
SGTC_2681 menadione 3.18 µM -1.77718942659046 0.0503662857612592 no 3189 0.0377685392582854 4641 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1241 0364-0022 50.8 µM -1.78318959793318 0.0497661550583865 no 3190 0.0372777225890178 4629 4563895
SGTC_2713 st079149 53.4 µM -1.78493364832155 0.0495927911873618 no 3191 0.0371360399949919 4643 3103253
SGTC_2432 5630864 12.22 µM -1.7854719009215 0.0495393846844972 no 3192 0.0370924025772871 4614 5714970
SGTC_219 mitoxanthrone 164.414 µM -1.78640690629169 0.04944672070832 no 3193 0.0370166991039231 4591 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2291 7917025 104.35 µM -1.79111103531645 0.0489826138878071 no 3194 0.036637739321273 4520 2964612
SGTC_2458 5808907 16.39 µM -1.79580675568243 0.0485228141048998 no 3195 0.0362626279729672 4710 2731747
SGTC_2936 9038235 15.59 µM -1.80044767684832 0.0480717776822337 no 3196 0.0358949891927238 4553 4749415
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.80109118465499 0.0480095029225019 no 3197 0.0358442544776036 4625 23847180
SGTC_665 3914-0008 307 µM -1.80155372784292 0.0479647807126309 no 3198 0.035807823475328 4596 1069549
SGTC_827 3253-0474 693 µM -1.80234201839288 0.0478886396057519 no 3199 0.0357458057524925 4636 5402065
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.80741813116521 0.0474006520828826 no 3200 0.035348554525638 4647 15053
SGTC_560 2332-1943 155 µM -1.80849672540272 0.0472974774146702 no 3201 0.0352646130039644 4631 21177716
SGTC_2653 dihydrofissinolide 100 µM -1.80894840684919 0.0472543246000399 no 3202 0.0352295095337381 4708 6857746
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.81314316843575 0.0468550704556191 no 3203 0.0349048712788977 4664 16486 A toxic proline analog.
SGTC_1264 0783-0040 158 µM -1.81355927827435 0.0468156133987144 no 3204 0.0348728022922784 4546 2855798
SGTC_1378 2093-0007 380 nM -1.81516159430172 0.0466639247925816 no 3205 0.0347495399196548 4633 3618014
SGTC_438 sphingosine 6.67 µM -1.81757074112549 0.0464365973380832 no 3206 0.0345648834932285 4583 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2450 5739737 12.93 µM -1.81812647502885 0.0463842845911293 no 3207 0.0345224021794214 4644 2262825
SGTC_1633 st005664 67.9 µM -1.82338051128621 0.0458920425272909 no 3208 0.0341228899568611 4619 2063822
SGTC_1410 3909-8106 77.9 µM -1.82953229160654 0.0453210363871745 no 3209 0.0336599531961069 4671 1039210
SGTC_234 nsc-17383 10.7 µM -1.84593268649133 0.0438266508000991 no 3210 0.0324509899500353 4650 408974
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.85166157850114 0.0433141048883958 no 3211 0.0320372172540986 4620 688761
SGTC_1198 1612-1005 86.7 µM -1.85216065035319 0.0432696846455531 no 3212 0.0320013787022383 4683 6998509
SGTC_982 1491-0518 27.5 µM -1.85455864376469 0.0430567623240488 no 3213 0.0318296392273545 4622 3091256
SGTC_850 0388-0143 75.9 µM -1.85746108244292 0.0428001824812688 no 3214 0.0316227915622288 4652 67273
SGTC_48 0382-0018 55 µM -1.87713066571695 0.0410937647992792 no 3215 0.0302500936812455 4655 762596
SGTC_854 0422-0053 192 µM -1.88144439918809 0.0407270060142175 no 3216 0.0299557460000671 4675 3596728
SGTC_3174 9107204 49.47 µM -1.88274221306747 0.0406171855790472 no 3217 0.0298676558664976 4651 3938802
SGTC_3033 9090887 49.47 µM -1.90395256592884 0.0388561994531464 no 3218 0.0284581810665885 4673 19325384
SGTC_3159 9100096 49.47 µM -1.9109409449735 0.0382897957983913 no 3219 0.0280060852300454 4616 25236875
SGTC_1944 st076371 56.9 µM -1.92464053322668 0.0371989880388756 no 3220 0.0271371724039493 4649 24208455
SGTC_1847 st056231 15 µM -1.9268590196736 0.0370247569483422 no 3221 0.0269986009115348 4655 5393180
SGTC_788 1182-0090 188 µM -1.92710478535371 0.0370054965985495 no 3222 0.026983286253528 4653 5715185
SGTC_2449 5812982 45.77 µM -1.92717657036983 0.0369998724420962 no 3223 0.0269788144060181 4599 776185
SGTC_1943 st076331 65.2 µM -1.93998426087438 0.0360075527951609 no 3224 0.0261908013456813 4640 24208415
SGTC_2436 5633522 8.09 µM -1.94844852530737 0.0353637974195463 no 3225 0.025680659166524 4653 5724242
SGTC_923 1900-2434 73.3 µM -1.95372154736587 0.0349675474762031 no 3226 0.0253670783133186 4637 5910570
SGTC_2266 7929956 200 µM -1.95756836296062 0.0346807771492925 no 3227 0.0251403413531496 4648 2967153
SGTC_2929 9013348 24.6 µM -1.97967402432934 0.0330700711250076 no 3228 0.0238700845901455 4647 2995952
SGTC_312 4092-0653 6.84 µM -1.98304569194075 0.0328299032555205 no 3229 0.0236811629833648 4582 1148278
SGTC_1550 gossypolone 36.6 µM -1.99147925120487 0.0322354617172388 no 3230 0.0232141120497456 4697 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1879 gemcitabine 100 µM -1.99329793914941 0.0321084424632922 no 3231 0.0231144159726147 4657 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3256 9138902 49.47 µM -2.00073849792479 0.0315930813447071 no 3232 0.0227102891661297 4761 17228773
SGTC_675 1309-0189 238 µM -2.01113601295976 0.0308843795867227 no 3233 0.022155546096698 4687 4246530
SGTC_1612 st002233 45.4 µM -2.0115908646938 0.0308536794490144 no 3234 0.0221315415908084 4705 1035021
SGTC_228 caffeine 993.056 µM -2.02297271454442 0.0300936509102772 no 3235 0.0215379803630758 4677 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_726 3448-4391 34.2 µM -2.02382731919554 0.0300372163016548 no 3236 0.0214939611274162 4722 1356692
SGTC_108 0509-0257 621.132 µM -2.0249817785949 0.0299611198750012 no 3237 0.0214346176502235 4675 536624
SGTC_1168 k815-0004 80.5 µM -2.0290033209254 0.0296972865766708 no 3238 0.0212289760321596 4680 642433
SGTC_2276 7947513 42.08 µM -2.03408371047478 0.0293667464809359 no 3239 0.0209715780328775 4617 2105100
SGTC_655 k060-0012 42 µM -2.04034821479605 0.0289633773008951 no 3240 0.0206578278967739 4711 5994525
SGTC_295 k015-0027 31 µM -2.04341705418583 0.0287674624959506 no 3241 0.020505585329817 4730 3887424
SGTC_2019 4016004 108 µM -2.05244894142531 0.0281972502515137 no 3242 0.020063026164458 4679 45595336
SGTC_3267 9137951 49.47 µM -2.06257870330666 0.0275689513983799 no 3243 0.019576336433642 4722 16643986
SGTC_2304 7443016 91.4 µM -2.06358863610947 0.0275069550726958 no 3244 0.0195283679805866 4658 939854
SGTC_948 3448-0295 75.3 µM -2.07118298665639 0.0270444773930894 no 3245 0.0191708494520428 4679 678569
SGTC_236 1509-0011 5.31 µM -2.07532600433566 0.0267949252582978 no 3246 0.0189781654728144 4700 3107280
SGTC_150 3970-0969 77.2 µM -2.07780134371105 0.0266467444242342 no 3247 0.018863830013464 4691 6615640
SGTC_32 0928-0142 34.1 µM -2.08272689645701 0.0263539226009582 no 3248 0.0186380621754567 4714 2244242
SGTC_534 k292-0788 63.4 µM -2.08692160515995 0.026106674238813 no 3249 0.0184476107801485 4722 4146317
SGTC_1734 st037168 69.4 µM -2.09758361936074 0.0254869434015785 no 3250 0.0179709716818578 4689 708907
SGTC_170 4197-0004 226 µM -2.10070694495569 0.0253077501491318 no 3251 0.0178333496534945 4691 218692
SGTC_78 0336-0123 156.75 µM -2.10550755740466 0.0250343853217191 no 3252 0.0176235750828368 4603 6765896
SGTC_2830 7992007 71.43 µM -2.11495697140054 0.0245035288918428 no 3253 0.0172168074008739 4644 1952075
SGTC_1763 st044482 94.5 µM -2.1155731247401 0.024469244774034 no 3254 0.0171905647949472 4706 88505
SGTC_2584 androsterone 48.74 µM -2.12063512095496 0.0241891055960714 no 3255 0.0169762600926624 4606 2754130 A steroid.
SGTC_651 3253-0966 34.4 µM -2.12275226978056 0.0240727406420801 no 3256 0.0168873082062738 4727 781462
SGTC_1453 4237-0541 195 µM -2.14882468846881 0.0226778721479365 no 3257 0.0158241497799971 4712 739892
SGTC_2893 9048488 25.97 µM -2.15516040700275 0.0223493957684849 no 3258 0.0155746420026617 4717 6467338
SGTC_3330 9141424 71.43 µM -2.15585243391195 0.0223137618647409 no 3259 0.0155475948316483 4710 27261020
SGTC_2244 6635614 200 µM -2.16033346521708 0.0220841823757502 no 3260 0.0153734320413597 4691 836499
SGTC_1184 1269-1718 139 µM -2.1629030244878 0.0219534362524836 no 3261 0.0152743195548875 4741 5403821
SGTC_680 0417-1641 114 µM -2.16790877450574 0.0217006064104451 no 3262 0.0150828140608329 4741 2835990
SGTC_114 0364-0001 490.298 µM -2.16886364916413 0.0216526581517796 no 3263 0.0150465186137129 4703 4003655
SGTC_1446 4239-0190 62 µM -2.17712079450506 0.0212417540033593 no 3264 0.0147357779615455 4722 1340085
SGTC_1930 st074634 34.3 µM -2.18383868492375 0.0209123320981335 no 3265 0.0144870519245841 4662 684253 YOR116C RPO31
SGTC_96 0929-0093 37.281 µM -2.18601108624285 0.020806734710497 no 3266 0.014407397127273 4733 6991579
SGTC_3239 9133757 49.47 µM -2.18901796270417 0.0206613198045494 no 3267 0.0142977672331608 4774 17036923
SGTC_2591 skatole 100 µM -2.20255141429057 0.0200174421949399 no 3268 0.0138131907759597 4687 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3274 9138298 49.47 µM -2.21424791184915 0.0194747517214813 no 3269 0.0134058648145152 4705 17015756
SGTC_2160 5660466 132.927 µM -2.2214406070882 0.019147272846604 no 3270 0.0131605666240268 4712 2859134
SGTC_2528 xanthyletin 44.79 µM -2.22430979129163 0.0190179531173391 no 3271 0.013063804197643 4730 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3350 9150499 3.57 µM -2.22526053770879 0.0189752652933988 no 3272 0.0130318764814151 4725 4910996 YPR165W RHO1
SGTC_1124 fisetin 1.16336 µM -2.23085040174407 0.0187259291890892 no 3273 0.0128455200229775 4724 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1320 1313-0481 95.3 µM -2.23192596287948 0.0186782749851155 no 3274 0.0128099283096412 4699 6813365 YLR208W SEC13
SGTC_1600 coumarin 106 71.1 µM -2.23540550762838 0.0185248155088504 no 3275 0.0126953694308869 4741 100336 A hepatotoxic, DNA x-linker.
SGTC_1852 st056254 31.4 µM -2.24405148277241 0.0181481405715991 no 3276 0.0124145445428535 4726 442583
SGTC_690 glyoxal 20.3 µM -2.25397315835277 0.0177239505598059 no 3277 0.0120989283178457 4563 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1652 st011932 78 µM -2.2645225734084 0.0172822309053032 no 3278 0.0117709964946028 4712 1551076
SGTC_2446 5162541 200 µM -2.27371590279769 0.0169049945093328 no 3279 0.0114915366949982 4718 1549321
SGTC_1396 3511-0007 98.6 µM -2.29341310211199 0.0161203922392673 no 3280 0.0109121165129904 4740 X1396
SGTC_3037 9091026 49.47 µM -2.31887374470866 0.015152615315588 no 3281 0.010200941560847 4642 25236398 YIL048W NEO1
SGTC_401 neomycin 50 µM -2.32719072185443 0.0148474930685105 no 3282 0.00997755831141597 4744 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3348 9149464 3.537 µM -2.33351151731604 0.014619151481982 no 3283 0.00981065727919075 4722 1951442
SGTC_926 2268-1401 59.4 µM -2.33458924370118 0.0145805211914856 no 3284 0.00978244450122128 4720 2931578
SGTC_1941 st076221 61.8 µM -2.34059797583365 0.0143667491031311 no 3285 0.00962644305369838 4675 2828568
SGTC_952 1185-0122 232 µM -2.34777102724398 0.0141150930018105 no 3286 0.00944306368894609 4709 678600
SGTC_839 0122-0028 230 µM -2.36297340962665 0.0135942698489716 no 3287 0.00906448515218951 4752 759448
SGTC_423 5-fluorouracil 457 µM -2.36774226374566 0.0134343472007543 no 3288 0.00894849929052657 4702 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_304 1310-0298 97 µM -2.3719449086098 0.0132947614154898 no 3289 0.00884736442907209 4536 1550234
SGTC_2688 kanamycin b 96.69 µM -2.37770067159878 0.0131056245304247 no 3290 0.00871048052924866 4693 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1279 0874-0590 65.2 µM -2.38118953274627 0.0129921147221594 no 3291 0.00862841525342979 4778 3523074
SGTC_2911 7942208 15.64 µM -2.38426957928113 0.0128926130713909 no 3292 0.00855653056887356 4733 1243384
SGTC_221 trifluoperazine 10.304 µM -2.39129459318739 0.0126681310042904 no 3293 0.0083945377571056 4730 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2066 5222451 176 µM -2.39923233065138 0.0124185608804667 no 3294 0.00821474336407207 4717 2281147
SGTC_2154 5570129 200 µM -2.42880892198465 0.0115257677607973 no 3295 0.00757425682091934 4770 673366
SGTC_2957 9076800 11.52 µM -2.4432255351898 0.0111111747512362 no 3296 0.00727831859330169 4718 16459615
SGTC_387 norethindrone acetate 66.7 µM -2.45865740719942 0.0106818154914044 no 3297 0.00697288134150654 4761 541197
SGTC_399 oxolinic acid 75 µM -2.45904207249739 0.0106713001715349 no 3298 0.00696541455980464 4748 4628 A DNA gyrase inhibitor.
SGTC_1179 1021-1431 9.29 µM -2.47434953845846 0.0102601036384894 no 3299 0.00667395158862739 4764 2840958
SGTC_2956 9076196 2.52 µM -2.47437222484363 0.0102595046272646 no 3300 0.00667352775082863 4744 16423868
SGTC_2079 5212404 121 µM -2.48187122324563 0.0100631647569226 no 3301 0.00653472489575582 4732 758462
SGTC_1650 st011916 45.8 µM -2.48899586196628 0.00987967209059445 no 3302 0.00640522283843981 4758 242528
SGTC_3322 9139058 2.11 µM -2.49149089583686 0.00981610763061453 no 3303 0.00636041135845191 4772 4908926 YPR165W RHO1
SGTC_634 1611-4317 11.2 µM -2.49554436702864 0.00971360123618325 no 3304 0.00628820133775404 4776 2843522
SGTC_552 k242-0005 476 µM -2.53908895466782 0.00867007034866536 no 3305 0.00555707802187757 4783 4088318
SGTC_43 0570-0105 72.5 µM -2.54563059236179 0.00852211245680448 no 3306 0.00545402770064256 4736 1114046 YDL195W SEC31
SGTC_87 0100-0052 35.5 µM -2.56610314204119 0.00807328760261328 no 3307 0.00514241203567737 4758 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1801 st050089 28.441 µM -2.57150050460446 0.00795847658157063 no 3308 0.00506294338936349 4777 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3314 9135860 59.4275 µM -2.58947784785764 0.00758635720612379 no 3309 0.0048060803533245 4760 25252478
SGTC_1712 st032288 53.4 µM -2.59036647631083 0.00756836726148996 no 3310 0.00479369031904923 4637 2883011
SGTC_2394 5221648 200 µM -2.59298481421847 0.00751557825874983 no 3311 0.00475734858483514 4759 788586
SGTC_1857 st056007 79.3 µM -2.59656122412028 0.00744399747417553 no 3312 0.00470810614907984 4769 619834
SGTC_1373 2887-0003 58.5 µM -2.59956127842195 0.00738441626488325 no 3313 0.0046671505652422 4746 776948
SGTC_2012 4023501 200 µM -2.6068043789365 0.0072422970627304 no 3314 0.0045695778091806 4749 3477460
SGTC_1287 0971-0001 34.6 µM -2.6334865134747 0.00673934978864977 no 3315 0.00422565960153198 4776 4665869
SGTC_371 0195-0006 7.36 µM -2.63526863049576 0.00670688457213102 no 3316 0.00420353595686117 4674 3928593
SGTC_389 tpck 16.7 µM -2.6397218584872 0.00662636261437269 no 3317 0.00414870470560948 4770 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3321 9137793 26.8275 µM -2.64596373270612 0.00651493767902885 no 3318 0.00407292746946891 4775 4904192
SGTC_1945 st075991 56.6 µM -2.64979966264207 0.00644728682770696 no 3319 0.00402697564374641 4766 1084980
SGTC_1354 1498-1681 81 µM -2.68364620277996 0.00587679633692412 no 3320 0.00364120631058501 4789 5754243
SGTC_2712 st079126 47.7 µM -2.68938118011941 0.00578469950866455 no 3321 0.00357923130560764 4783 3152970
SGTC_2165 5727197 32.143 µM -2.68995557077127 0.00577554642037532 no 3322 0.00357307662226869 4754 1361712
SGTC_1273 0849-0096 14.1 µM -2.69019883341342 0.00577167383246951 no 3323 0.00357047289105847 4778 5286025
SGTC_633 0437-0093 97.7 µM -2.70415269800169 0.00555335819930522 no 3324 0.0034239406327937 4750 2831118
SGTC_100 0086-0128 49.5915 µM -2.72277492351611 0.00527344268124259 no 3325 0.00323680726787442 4772 93297
SGTC_2005 4024620 188 µM -2.78599961659875 0.00441439266556627 no 3326 0.00266814674143745 4755 236743
SGTC_377 3970-0964 33.1 µM -2.85615089151356 0.00360944854657545 no 3327 0.00214405644934095 4779 16481235
SGTC_1342 1486-1464 234 µM -2.88042496755478 0.00336324932964948 no 3328 0.00198569734033981 4797 3253938
SGTC_2043 5101342 149 µM -2.89420790584895 0.00323027517224639 no 3329 0.00190058192308785 4790 678451
SGTC_168 3970-0862 530.542 µM -2.91456323528252 0.00304253435620301 no 3330 0.00178093320488751 4753 3135186
SGTC_2448 5185112 27.17 µM -2.92840924155314 0.00292050737452952 no 3331 0.00170350641454658 4779 5718189
SGTC_573 3702-0553 84.7 µM -2.93424059581314 0.0028704485529958 no 3332 0.00167182456716582 4789 1222756
SGTC_676 falcarinol 140 µM -2.95049569669995 0.00273496662443048 no 3333 0.00158632232027346 4788 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_841 0251-0215 91.2 µM -3.06797803773419 0.00191530039807911 no 3334 0.001077562281243 4799 3888614
SGTC_50 0929-0078 56.389 µM -3.07360523058533 0.00188233004507736 no 3335 0.00105744542766968 4753 1377751
SGTC_662 k832-1615 104 µM -3.09248237182519 0.0017754595666045 no 3336 0.000992450111092401 4792 5878478
SGTC_2250 alverine citrate 130 µM -3.12725216114225 0.00159294895230287 no 3337 0.000882242589109887 4721 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1380 2291-0730 164 µM -3.14532445588285 0.00150499657871303 no 3338 0.000829513625310301 4788 2999191
SGTC_101 0490-5701 117.494 µM -3.27121360172567 0.00100526406586174 no 3339 0.000535434967879746 4788 4661669
SGTC_2635 hydroquinidine 100 µM -3.34638747093853 0.000784797887763589 yes 3340 0.000409359513670766 4779 442912 An experimental heart treatment.
SGTC_409 arachidonic acid 100 µM -3.35645405177761 0.00075892029549432 yes 3341 0.000394744190682081 4797 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1263 0774-1208 64.8 µM -3.38974143562956 0.000678843854334113 yes 3342 0.000349792873257828 4787 906585
SGTC_598 3937-0236 20.2 µM -3.39734864581582 0.00066167339979666 yes 3343 0.00034021108119855 4806 1379313
SGTC_528 3492-0019 172 µM -3.41089534192682 0.000632085448760154 yes 3344 0.000323749699781633 4798 2869262
SGTC_1463 k081-0032 34.1 µM -3.44437074089067 0.000564130663074156 yes 3345 0.000286195124465161 4524 977755
SGTC_2982 9019404 25.97 µM -3.47502245445595 0.000507896160562104 yes 3346 0.000255405295562676 4789 22333232
SGTC_2242 6630449 61.2675 µM -3.53810671886884 0.000408117681630571 yes 3347 0.000201503569842931 4800 691249 YDR170C SEC7
SGTC_654 1124-0271 80.9 µM -3.59450114206464 0.000334641207837403 yes 3348 0.00016250685980978 4806 5403748
SGTC_2344 7990960 76.95 µM -3.69532181930916 0.00023303571549781 yes 3349 0.000109804223135064 4801 140813
SGTC_2347 9049783 174.81 µM -3.90948633818105 0.000104860423495464 yes 3350 4.62462929648532e-05 4800 6467988 YPL169C MEX67
SGTC_3300 9124615 50.48 µM -3.94327300393119 9.21049211764262e-05 yes 3351 4.01885342846891e-05 4805 24824903
SGTC_1131 3454-3128 32.3 µM -4.11719777011327 4.64866930303432e-05 yes 3352 1.9175347968603e-05 4797 710982
SGTC_95 0471-0001 561.058 µM -4.24465574135276 2.76861740856788e-05 yes 3353 1.09464634837041e-05 4806 4015405
SGTC_2007 4011539 71.82 µM -4.32584958096196 1.97514144584373e-05 yes 3354 7.59725432186402e-06 4808 45595301
SGTC_137 0438-0332 85.389 µM -4.8027534809028 2.41111315847272e-06 yes 3355 7.82492567426368e-07 4801 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3311 9131146 2.8755 µM -6.06290261147891 3.45357171244252e-09 yes 3356 6.6843310749573e-10 4809 4900406 YPR165W RHO1