SGTCid condition conc unit UTP7|YER082C.score UTP7|YER082C.strain.pval UTP7|YER082C.strain.significant UTP7|YER082C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1321 1326-2144 215 µM 4.4136902186183 1.49614576971822e-05 yes 1 5.08116728298698e-06 1 3513030
SGTC_1144 3486-0183 12.5 µM 3.73424165678184 0.000206585540969796 yes 2 9.41408228931929e-05 6 6744069
SGTC_909 3448-9333 149 µM 3.49452124950816 0.000475168756604179 yes 3 0.000237456401292893 3 3344074
SGTC_3301 9125354 19.7965 µM 3.44146928853805 0.000567637586959894 yes 4 0.000289282072345919 3 41905162
SGTC_3008 9078912 71.4286 µM 3.40516009623728 0.000640225530075192 yes 5 0.000330626375925454 5 16648731
SGTC_1575 cyproterone acetate 48 µM 3.31358729244062 0.000863001529821901 yes 6 0.000460536754007573 14 9880 An androgen receptor antagonist and liver toxin.
SGTC_1682 st012968 530 nM 3.26337842976885 0.00101349748864324 no 7 0.000550462029588061 10 24207270
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 3.07694639107379 0.00180745062567028 no 8 0.00104566454362614 22 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_999 SEC7.066 22.7 µM 2.93528739933536 0.00275173158327085 no 9 0.00166619440362937 27 740511 YDR170C SEC7
SGTC_1564 D-Arginine 115 µM 2.93355253767341 0.00276564845077888 no 10 0.00167553467307987 20 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2601 securinine 100 µM 2.9188569596658 0.00288610666477301 no 11 0.00175658694774012 37 442872 A GABA receptor antagonist.
SGTC_429 1112-0049 25.5 µM 2.91672731409918 0.00290395024318082 no 12 0.00176862434514153 21 2836170
SGTC_1163 k060-0048 49.9 µM 2.91328192918584 0.0029330286563619 no 13 0.00178825770417781 9 6809982
SGTC_1819 st053448 58.6 µM 2.90145164920981 0.0030348825976192 no 14 0.00185719047727264 15 2857616
SGTC_430 0958-0115 16.4 µM 2.87706461450962 0.0032549595264945 no 15 0.00200696697451253 26 6833180
SGTC_304 1310-0298 97 µM 2.86796623825214 0.00334067516608883 no 16 0.00206559807516971 15 1550234
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.86251102389836 0.00339303653268113 no 17 0.00210149319657938 17 442882
SGTC_300 r073-0011 5.04 µM 2.86062913069257 0.00341127009282452 no 18 0.00211400665135409 11 2735780
SGTC_2234 tolnaftate 200 µM 2.84723836276407 0.00354357500136114 no 19 0.00220501640836812 2 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1728 st035614 33.7865 µM 2.79509386281283 0.00410377602823779 no 20 0.00259423242690389 22 15945546
SGTC_1164 k060-0068 93.7 µM 2.78783280027392 0.00418776984944938 no 21 0.00265309609586594 13 5963676
SGTC_2762 leflunomide 42.06 µM 2.73921237417385 0.00479092117817112 no 22 0.00307932882094474 22 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1046 2001-0062 216 µM 2.71835571511534 0.005072579253698 no 23 0.00328036314788631 17 739778
SGTC_2287 7945887 168.79 µM 2.68473219638792 0.00555776618101881 no 24 0.00362939713812364 12 1245853
SGTC_2832 7992762 51.95 µM 2.67746660685117 0.00566787235292314 no 25 0.00370906233370834 26 2985177
SGTC_752 1896-0090 130 µM 2.65407279078995 0.00603566480249204 no 26 0.00397633347484758 24 772567
SGTC_1842 st055362 61.2 µM 2.62385843744533 0.00654190719952288 no 27 0.00434699559434848 10 676032
SGTC_1677 st019204 53.9 µM 2.59970432531465 0.00697325491523065 no 28 0.00466520570792247 24 3945625
SGTC_2016 5121758 140 µM 2.58635124480644 0.00722233575221351 no 29 0.00484990144930758 49 2795203
SGTC_3005 9076496 71.4286 µM 2.56811383987838 0.00757518879001944 no 30 0.00511267847105206 16 21368410
SGTC_2280 7785178 200 µM 2.55330119433155 0.00787286424694565 no 31 0.00533535881346357 15 2954328
SGTC_98 0074-0023 107.663 µM 2.53321737229847 0.00829288011776313 no 32 0.00565104207362247 18 3563821
SGTC_2264 7948757 110.76 µM 2.50193240336731 0.00898637209795574 no 33 0.00617587528563611 16 2971411
SGTC_303 1348-1668 34.2 µM 2.50117381480295 0.00900380040498127 no 34 0.00618912051141016 26 5380509
SGTC_2300 7976697 71.57 µM 2.49222466460406 0.00921164952359691 no 35 0.00634728558241764 18 2236109
SGTC_1045 1348-1485 165 µM 2.47860620166958 0.00953600394971264 no 36 0.00659484193820936 28 6810614
SGTC_1159 4092-0538 61.2 µM 2.46944417469308 0.00975979686137686 no 37 0.00676615656354673 30 717301
SGTC_573 3702-0553 84.7 µM 2.44782890605281 0.0103060377511899 no 38 0.00718599420996252 27 1222756
SGTC_144 4161-2749 112.381 µM 2.43357443676375 0.0106806829783891 no 39 0.00747528051708564 48 797501 YMR168C CEP3
SGTC_1062 mesoridazine 14.2 µM 2.39171850941515 0.0118501137765883 no 40 0.00838484919941817 33 4078 A neuroleptic.
SGTC_771 0250-0039 27.3 µM 2.38096057093113 0.0121680594468774 no 41 0.0086337800449671 32 3005115
SGTC_1327 1436-0082 2.18 µM 2.36610218847147 0.0126193351783769 no 42 0.00898824091004112 38 15992205
SGTC_2607 solasodine 47.35 µM 2.35463596805082 0.0129774197326109 no 43 0.00927042962611262 55 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_962 1254-0300 21.5 µM 2.34427495454001 0.0133085114815907 no 44 0.00953205576711702 16 7340576
SGTC_2801 7907800 81.82 µM 2.32838140611878 0.0138305733506325 no 45 0.0099459300464778 34 6620925
SGTC_389 tpck 16.7 µM 2.28198766494726 0.0154566784598305 no 46 0.0112450342589172 26 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2835 9006588 71.43 µM 2.27990759234739 0.0155332776339456 no 47 0.0113065848378214 34 2345538
SGTC_2276 7947513 42.08 µM 2.25684835526932 0.0164044953564536 no 48 0.012008776016513 27 2105100
SGTC_1018 4259-0013 28.1 µM 2.25250287822542 0.0165732771498701 no 49 0.0121452555184636 33 6801262
SGTC_1228 0124-0032 52.5 µM 2.23052419095776 0.0174498926614842 no 50 0.0128563316521881 33 X1228
SGTC_1437 4092-1038 11.6 µM 2.2274879149427 0.0175740524457039 no 51 0.0129573413012524 36 3977136
SGTC_353 1988-1175 58.3 µM 2.2268836952955 0.0175988500279407 no 52 0.0129775239044987 54 2788357
SGTC_2070 5230947 200 µM 2.22144512917676 0.0178233997276743 no 53 0.0131604136318946 27 2835538
SGTC_1443 4112-3303 14 µM 2.21604535418008 0.0180487611675121 no 54 0.0133441980763404 28 704433
SGTC_3019 9081971 49.47 µM 2.21572276288582 0.0180623011826356 no 55 0.0133552474813639 41 16451803
SGTC_993 3909-8757 62.7 µM 2.19761407101162 0.018836382595294 no 56 0.0139883098206473 27 4288324 YLR208W SEC13
SGTC_2271 7849410 118.62 µM 2.19722162586427 0.0188534659361772 no 57 0.014002310917407 28 972430
SGTC_1429 4049-0205 9.46 µM 2.1810916171008 0.0195671073944619 no 58 0.0145883203792799 33 22774478
SGTC_1473 k844-0725 134 µM 2.17198471975223 0.0199800645559258 no 59 0.014928407743452 55 54682906
SGTC_94 0334-0113 514.748 µM 2.16524240756082 0.0202905410416126 no 60 0.015184563142131 31 6795178
SGTC_1373 2887-0003 58.5 µM 2.16149875602027 0.0204646914872172 no 61 0.015328416472384 60 776948
SGTC_681 1642-0006 26.6 µM 2.15443868706242 0.0207965656151977 no 62 0.0156028927008321 31 4446530
SGTC_181 1447-1644 8.07 µM 2.15440805569012 0.0207980153801319 no 63 0.0156040926943532 52 534600
SGTC_2273 7815444 169.05 µM 2.14395690035021 0.0212976830950515 no 64 0.0160181701657311 49 2824616
SGTC_599 1935-0052 86.5 µM 2.14029660777901 0.0214750645520098 no 65 0.016165401980458 33 9557311
SGTC_1193 1488-0126 41.5 µM 2.13748624782402 0.0216121034846907 no 66 0.0162792315385621 35 1384710
SGTC_1674 st016616 23.6 µM 2.1366451796904 0.0216532590866913 no 67 0.0163134309799818 43 625830
SGTC_2197 6588183 93.1375 µM 2.13265253235985 0.0218495338759695 no 68 0.0164766202578776 27 884136
SGTC_524 r073-0010 27.8 µM 2.12702910713955 0.0221285230024761 no 69 0.0167088324081127 61 2772106
SGTC_3156 9099931 49.47 µM 2.11686211811549 0.022640560228999 no 70 0.0171357757611595 32 18111053
SGTC_92 0063-0024 660.874 µM 2.10687026452061 0.0231534720797808 no 71 0.017564413381538 35 3594437
SGTC_1438 4092-1045 4 µM 2.10686921225328 0.0231535266067798 no 72 0.0175644590000637 48 1351342
SGTC_2343 7990716 14.84 µM 2.10117178279626 0.0234503486179326 no 73 0.0178129447139312 46 6456862
SGTC_2023 5144124 124 µM 2.09322319751496 0.0238697939914757 no 74 0.0181646174429555 37 2830192
SGTC_1839 st053978 48 µM 2.08905658301561 0.024092173123322 no 75 0.0183513150065558 27 3788398
SGTC_1816 st051957 91.6 µM 2.08659558338247 0.0242243365173044 no 76 0.0184623534344826 33 674121
SGTC_1747 st037496 66.6 µM 2.07627117992217 0.0247854432636049 no 77 0.0189344386193784 60 723305
SGTC_1156 4092-0367 4.88 µM 2.06085317035675 0.0256436432505818 no 78 0.0196585250500703 60 1357585
SGTC_1063 disulfiram 1.84 µM 2.04684083927485 0.0264450437610276 no 79 0.0203368571888918 56 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_678 1218-2179 85.9 µM 2.03977623023032 0.0268569574907067 no 80 0.0206863091640346 28 6820081 YOR116C RPO31
SGTC_2783 7738165 71.43 µM 2.03952943186826 0.0268714437744436 no 81 0.0206986084510507 45 17201110
SGTC_901 1112-0062 60.1 µM 2.03383797842699 0.0272073281980835 no 82 0.0209839669813373 41 1908457
SGTC_888 0916-0002 6.97 µM 2.03329415901599 0.0272396045471647 no 83 0.0210114064723662 40 2802138 YIL048W NEO1
SGTC_3015 9080845 49.47 µM 2.0277898856041 0.0275680912878447 no 84 0.0212908485430623 41 5296973
SGTC_657 3534-0529 86.7 µM 2.02106610550733 0.0279738303816376 no 85 0.0216364612272823 38 1049549
SGTC_2279 7948423 32.93 µM 2.00580029241986 0.0289135174797006 no 86 0.0224387797307989 51 1247112
SGTC_2956 9076196 2.52 µM 2.00538485171497 0.0289394522461819 no 87 0.0224609599441784 42 16423868
SGTC_677 0929-0063 136 µM 2.00341401466794 0.0290627494875355 no 88 0.0225664342144767 31 1539583
SGTC_204 PMA1.184 62.41 µM 2.00047320436801 0.0292475404192174 no 89 0.0227245952739171 54 2252213 YGL008C PMA1
SGTC_830 4076-0286 57.8 µM 1.99913477783475 0.029331965358852 no 90 0.0227968865647624 49 6866659
SGTC_2210 7115885 190.385 µM 1.9765629633697 0.0307864932263354 no 91 0.0240455260359772 49 2927039
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.96327665081404 0.0316702386021252 no 92 0.0248070185059444 53 5379071
SGTC_1848 st056003 16.4 µM 1.95759257257492 0.0320546684813083 no 93 0.0251389197991173 55 146492
SGTC_795 0685-0265 78 µM 1.95579104555035 0.0321773118417114 no 94 0.0252448870786395 80 302754
SGTC_422 cantharidin 155 µM 1.95488186010023 0.0322393537834242 no 95 0.0252985080544393 57 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2931 9014674 55.67 µM 1.95483548298139 0.0322425211582716 no 96 0.0253012457908824 41 2996810
SGTC_2293 7624732 200 µM 1.95351322107836 0.0323329345517105 no 97 0.0253794061095685 56 894453
SGTC_22 0964-0034 14.468 µM 1.94368029604244 0.0330118712331665 no 98 0.0259670080826218 94 138402
SGTC_2111 5486399 200 µM 1.93718427371839 0.0334668157754559 no 99 0.0263614109611415 68 689674
SGTC_970 1315-0089 19.5 µM 1.93714147953349 0.0334698298652175 no 100 0.026364025698584 54 6811083 YLR033W RSC58
SGTC_170 4197-0004 226 µM 1.93629405509494 0.0335295619002948 no 101 0.0264158482479879 67 218692
SGTC_121 0557-0495 61.343 µM 1.92707044032329 0.0341853956700501 no 102 0.0269854259959677 68 3104427
SGTC_2830 7992007 71.43 µM 1.92585332153991 0.0342727197459061 no 103 0.0270613456529741 58 1952075
SGTC_2622 2-methoxyxanthone 59.94 µM 1.92496259084071 0.0343367427194442 no 104 0.027117019237761 50 71034 A hepatoprotective.
SGTC_1774 st048371 48.465 µM 1.92250266355394 0.0345140653917527 no 105 0.0272712693834898 75 4242727
SGTC_682 0kpi-0099 17 µM 1.92016368375962 0.034683366671871 no 106 0.0274186136247219 111 1714895 YML126C ERG13
SGTC_1840 st055363 71 µM 1.9119478027277 0.0352834661768669 no 107 0.0279414447133599 45 676033
SGTC_1648 st011736 69.8 µM 1.91132932483284 0.0353289832643088 no 108 0.0279811364079335 54 2855514
SGTC_2417 cerulenin 830 nM 1.91131933356007 0.0353297189704654 no 109 0.0279817779972392 59 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1659 st012954 42.1 µM 1.91065235524472 0.0353788602628792 no 110 0.028024635709083 49 24207262
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.90746713866757 0.0356143126731217 no 111 0.0282300612405132 54 5355888
SGTC_1608 st001473 40.5 µM 1.90542687021722 0.0357658038505244 no 112 0.02836230256971 79 7292267
SGTC_2072 5231554 129 µM 1.90179218087217 0.0360369898440574 no 113 0.0285991644582105 54 789545
SGTC_2979 9012552 45.46 µM 1.9002181477176 0.036154950667995 no 114 0.0287022488418995 50 17100905
SGTC_1838 st055369 84.5 µM 1.89311844687196 0.0366909501152799 no 115 0.029171059763338 53 676036
SGTC_856 0433-0016 11.3 µM 1.88876472579836 0.0370228417432395 no 116 0.0294616806541758 47 3911780
SGTC_574 1315-0397 40 µM 1.8775167267805 0.0378916671577438 no 117 0.030223653499075 73 6794277
SGTC_1229 0139-0193 12.2 µM 1.87742981708548 0.037898444513205 no 118 0.0302296040161285 82 3090752
SGTC_1777 st045864 34.765 µM 1.87547299325371 0.0380513027675293 no 119 0.0303638407450263 69 4691462
SGTC_347 4534-1311 26.2 µM 1.87503442560959 0.0380856305931859 no 120 0.0303939938322085 46 2862016
SGTC_521 r062-0005 13.8 µM 1.87373657067088 0.03818736507177 no 121 0.0304833713595758 56 2832033
SGTC_1993 st073995 70.8 µM 1.87351358757738 0.0382048662545989 no 122 0.0304987491141682 58 3098394
SGTC_1732 st034308 51.822 µM 1.87020569502269 0.0384652605352736 no 123 0.0307276295894214 72 830119
SGTC_1588 farnesol 29.9 µM 1.86409223685459 0.0389503128524347 no 124 0.0311543762707553 57 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2173 5763948 167 µM 1.85611415162769 0.0395907867522754 no 125 0.031718644520964 55 2867177
SGTC_2945 9067681 61.76 µM 1.85544237925052 0.0396451047706178 no 126 0.0317665401661793 72 16456930
SGTC_2017 5132927 60.65 µM 1.85509799336052 0.0396729745351973 no 127 0.0317911171539513 42 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2984 9022109 38.96 µM 1.85268685155985 0.0398685450511343 no 128 0.0319636278413637 61 6459207
SGTC_885 0865-0106 16.8 µM 1.85247042229247 0.0398861381416951 no 129 0.0319791505100755 68 2793380
SGTC_331 k048-0133 24.5 µM 1.85117118635607 0.0399918830440226 no 130 0.0320724647873341 69 6813582
SGTC_2833 9001315 45.46 µM 1.84436619601702 0.0405494690469578 no 131 0.0325648951487117 67 2989378
SGTC_1865 st057639 52.2 µM 1.83983462006368 0.0409242648546877 no 132 0.0328962605203837 61 688818
SGTC_1986 st071812 45 µM 1.83460863092267 0.0413599777301092 no 133 0.0332818494633644 45 11838594
SGTC_414 piperonyl butoxide 100 µM 1.82895106211361 0.0418359037896856 no 134 0.0337034698894259 65 5794 A potent inhibitor of cytochrome P450.
SGTC_2715 st079500 56.4 µM 1.82612684498358 0.0420751366702046 no 135 0.0339155787029076 63 28246688
SGTC_1235 benzylparaben 21.5 µM 1.82424328317314 0.0422353034235876 no 136 0.0340576503369864 65 7180
SGTC_1076 itraconazole 331 nM 1.81724809123229 0.0428344554292028 no 137 0.0345895671362182 74 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_313 3474-0040 5.03 µM 1.81143553983733 0.0433375210945727 no 138 0.0350367293724236 85 1043375 YIL048W NEO1
SGTC_757 1066-0008 322 µM 1.79398408892541 0.0448766284915643 no 139 0.0364078542336249 68 6842497
SGTC_906 1165-0455 526 µM 1.79195208419709 0.0450586638299225 no 140 0.036570320876119 51 3252859
SGTC_3053 9095903 49.47 µM 1.78445165645492 0.0457357337565323 no 141 0.0371751518178393 65 17174018
SGTC_1481 3346-2004 36 µM 1.78344801999165 0.0458269499887514 no 142 0.0372567011542679 65 2770522
SGTC_2706 st078239 82.5 µM 1.78039972671811 0.0461048929919196 no 143 0.0375052832346392 74 15434492
SGTC_3212 9128307 49.47 µM 1.77801654873346 0.0463231326194471 no 144 0.0377005684912856 70 27243542
SGTC_1594 piperine 70.1 µM 1.77732114054081 0.0463869707423834 no 145 0.0377577086543424 52 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2231 micatex 6.853 µM 1.77462674114665 0.046634982479329 no 146 0.037979769405501 67 20737 An antifungal of unknown mechanism.
SGTC_1833 st055984 71 µM 1.76668448597083 0.0473722396140926 no 147 0.0386405414851519 52 676288
SGTC_1545 lovastatin 49.4 µM 1.75446480834249 0.048524766195726 no 148 0.0396754474407906 84 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_166 k072-0058 166.424 µM 1.75160114720535 0.0487980759359063 no 149 0.039921207592587 80 5846229
SGTC_2062 5245942 200 µM 1.74955780126297 0.0489938453063645 no 150 0.0400973233496135 56 1376160
SGTC_2051 5263410 176 µM 1.74364655818288 0.0495637259265325 no 151 0.0406103697491922 66 227584
SGTC_2853 9015042 58.44 µM 1.7389050353553 0.0500246512820662 no 152 0.0410257341897311 51 6457456
SGTC_3085 9117376 49.47 µM 1.73644511955071 0.0502651237659487 no 153 0.0412425801066712 68 16480349
SGTC_2244 6635614 200 µM 1.7348683760715 0.0504197444487946 no 154 0.0413820608306152 42 836499
SGTC_362 0310-0100 9.03 µM 1.72806714991676 0.0510910428991669 no 155 0.0419880930804793 61 790235
SGTC_1486 3970-0793 4.53 µM 1.72398953817192 0.051496912015059 no 156 0.0423548659069941 75 2844330
SGTC_424 splitomicin 100 mM 1.71960096992191 0.0519365928998941 no 157 0.0427524998770203 60 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_663 1486-0733 13.9 µM 1.71934310100243 0.0519625207144993 no 158 0.0427759580936681 80 722445 YPR165W RHO1
SGTC_3046 9092212 49.47 µM 1.71504201771908 0.0523964976786896 no 159 0.0431687618039847 58 25236637
SGTC_1474 0330-0125 5.35 µM 1.71490591094438 0.0524102776061225 no 160 0.0431812393823759 60 X1474
SGTC_1775 st081588 35.1725 µM 1.71406033853906 0.0524959507943978 no 161 0.0432588224445825 81 1426443 YGL099W LSG1
SGTC_1623 st003709 20.3 µM 1.7075858392075 0.0531556351673162 no 162 0.0438566088878878 71 16192618
SGTC_129 0088-0017 176.636 µM 1.69628630430896 0.0543226680764045 no 163 0.0449158364481713 57 182446
SGTC_3356 9151811 4.48 µM 1.69380341110884 0.0545818017458742 no 164 0.0451513228535756 77 1859254 YPR165W RHO1
SGTC_741 4582-0002 126 µM 1.68191796630742 0.055835822334287 no 165 0.0462923741444628 70 2912688
SGTC_1992 st073643 23.3 µM 1.6758636331293 0.0564832899273608 no 166 0.0468824532518237 74 3161292
SGTC_2467 5474540 200 µM 1.67037156136053 0.0570757323400832 no 167 0.0474229363228968 84 5413519
SGTC_2228 7354201 200 µM 1.66990015800095 0.057126810817305 no 168 0.0474695595431514 77 753451
SGTC_2242 6630449 61.2675 µM 1.66825820129995 0.0573050045017725 no 169 0.0476322408205832 62 691249 YDR170C SEC7
SGTC_318 1488-0629 67.2 µM 1.66701363876683 0.0574403620833061 no 170 0.0477558464598326 67 3662576
SGTC_1197 1601-0112 267 µM 1.66368391057026 0.0578037373562931 no 171 0.0480878066233716 76 7350313
SGTC_2936 9038235 15.59 µM 1.65613566573792 0.0586341734335634 no 172 0.0488471740278412 89 4749415
SGTC_2146 5545642 200 µM 1.63184854793843 0.0613698338793534 no 173 0.0513556976152489 82 825326
SGTC_126 0417-1624 672.48 µM 1.63124281438652 0.0614393158594383 no 174 0.0514195472615792 114 41912 YDL195W SEC31
SGTC_2680 butyl paraben 22.24 µM 1.62360225135294 0.0623210281664556 no 175 0.0522303623318609 82 7184 An antifungal and steroid mimetic.
SGTC_122 0236-0016 402.397 µM 1.62176896254406 0.0625340485877066 no 176 0.0524264132088832 108 6808838
SGTC_146 3448-8650 53.125 µM 1.62096749747468 0.0626273535827413 no 177 0.0525123047569365 98 2891488 YIL048W NEO1
SGTC_2656 pseudo-anisatin 100 µM 1.62004838005239 0.0627344889724594 no 178 0.0526109423463397 58 6708809 A neurotoxin.
SGTC_2565 isoliquiritigenin 100 µM 1.61565739763622 0.0632482887492638 no 179 0.0530842033529232 87 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2779 methotrexate 400 µM 1.6048618758011 0.0645254286859025 no 180 0.054262102604268 92 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1104 tacrolimus 29.8 µM 1.60436227359671 0.0645850145039584 no 181 0.0543171108842249 103 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1452 4194-0072 190 µM 1.59951008930873 0.0651659431228 no 182 0.0548536543036509 93 1343545
SGTC_1526 st051518 75 µM 1.59762361435961 0.0653928932510686 no 183 0.0550633838797124 74 673993
SGTC_868 0527-0199 213 µM 1.59695371941328 0.06547363150887 no 184 0.0551380119606679 82 2849450
SGTC_2962 9082311 13.18 µM 1.59678957974842 0.0654934260256345 no 185 0.0551563097383861 102 16459453
SGTC_1274 0865-0114 173 µM 1.59572777522579 0.0656215870859762 no 186 0.055274792298336 104 870624
SGTC_1914 st062367 72.6 µM 1.59073263852067 0.0662271166665201 no 187 0.0558348791585427 99 978205
SGTC_1017 4239-0030 168 µM 1.58706451614737 0.0666745296495856 no 188 0.0562490167115274 87 1149593
SGTC_1366 1683-0113 21.9 µM 1.58371737297183 0.0670848295819793 no 189 0.0566290247579588 75 708623
SGTC_531 3788-1495 174 µM 1.58173146988449 0.0673291871304828 no 190 0.0568554426705719 72 2896655
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.58037618440489 0.0674963442789072 no 191 0.0570103711173406 81 5106787 A p450 inhibitor.
SGTC_3268 9137683 49.47 µM 1.57892060592407 0.0676762282777075 no 192 0.0571771344695041 90 1953228
SGTC_9 0092-0002 10.449 µM 1.57780613745093 0.0678142072242727 no 193 0.0573050767133272 91 759368
SGTC_2776 terbinafine 19.92 µM 1.57538550090618 0.0681146472331447 no 194 0.0575837445326048 95 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2961 9083290 32.55 µM 1.57235505348874 0.0684922217461241 no 195 0.0579341159405475 74 17741490
SGTC_947 3447-0010 211 µM 1.56942624853294 0.0688586645467581 no 196 0.0582743259244023 98 748350
SGTC_3002 9075603 71.4286 µM 1.56894113684965 0.0689195058212964 no 197 0.0583308276901421 94 20105405
SGTC_1857 st056007 79.3 µM 1.55934540890068 0.0701315084446862 no 198 0.0594573248071225 61 619834
SGTC_392 N-ethylmaleimide 8.33 µM 1.55308266702126 0.0709313323909681 no 199 0.060201693221211 103 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3163 9099914 49.47 µM 1.54977142160363 0.0713570385419187 no 200 0.0605981943267592 81 16268368
SGTC_306 1672-3436 11.6 µM 1.54888208886247 0.0714717079238223 no 201 0.0607050336728973 85 6797378
SGTC_1178 0988-0033 191 µM 1.54863587336071 0.0715034796050953 no 202 0.0607346386192948 82 5392207
SGTC_2465 5809242 33.21 µM 1.53193383737768 0.0736841160108043 no 203 0.0627693812274038 93 2731748
SGTC_510 ag-490 170 µM 1.53007032378138 0.0739305374625314 no 204 0.0629996614648417 68 5328779
SGTC_816 0325-0417 81.3 µM 1.52971697659032 0.0739773332180949 no 205 0.0630433998152509 95 68101
SGTC_1518 st038567 90.8 µM 1.5278516829658 0.0742247396983779 no 206 0.0632746834136627 88 77966
SGTC_2592 piperlongumine 83.33 µM 1.52008663120315 0.0752614659493667 no 207 0.0642446020570023 98 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1464 k208-0027 110 µM 1.51831956592579 0.0754989247304618 no 208 0.0644669287796839 112 X1464
SGTC_3051 9093778 49.47 µM 1.51711613176239 0.0756609691117932 no 209 0.0646186830185173 109 17217378
SGTC_1497 4476-2978 41.3 µM 1.5169232549926 0.0756869649024036 no 210 0.0646430307475165 96 1528379
SGTC_879 0831-1030 162 µM 1.5156606986583 0.0758572993980593 no 211 0.0648025851036489 133 1549252
SGTC_3172 9105863 49.47 µM 1.51544009953682 0.0758870908905772 no 212 0.0648304944628482 68 2348785
SGTC_3120 9124077 49.47 µM 1.51332760986555 0.0761728299558181 no 213 0.0650982314071801 77 18774327 YGL155W CDC43
SGTC_2446 5162541 200 µM 1.51312604115349 0.076200137234167 no 214 0.0651238230048684 87 1549321
SGTC_1005 4092-0690 4.4 µM 1.5090851088798 0.0767491508451809 no 215 0.0656385172449377 117 1529343
SGTC_1056 3448-1962 115 µM 1.50729875973435 0.0769928063423921 no 216 0.0658670476838702 104 715507
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.50362799653006 0.0774953380106952 no 217 0.0663385891594423 100 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_237 nikkomycin 200 µM 1.49184812646585 0.0791248424824077 no 218 0.0678694820478855 100 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2203 7227154 166.4 µM 1.4913347427516 0.0791964442066783 no 219 0.0679368158602415 72 896304
SGTC_2416 tofa 880 nM 1.49013034254718 0.0793646146687731 no 220 0.0680949837006304 83 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1378 2093-0007 380 nM 1.48635516188636 0.0798934949190081 no 221 0.0685926015746159 109 3618014
SGTC_1244 0416-0015 52.5 µM 1.48603452668999 0.0799385364999556 no 222 0.0686349943489617 91 96201
SGTC_1253 0550-0034 176 µM 1.48243059102176 0.0804461249374102 no 223 0.0691128796472185 107 5969915
SGTC_982 1491-0518 27.5 µM 1.48090373463721 0.0806619045710008 no 224 0.0693161138540574 81 3091256
SGTC_3052 9092717 49.47 µM 1.47820820075076 0.0810439115730848 no 225 0.0696760297789891 94 25237534
SGTC_855 0428-0020 25 µM 1.47740887435387 0.081157452974911 no 226 0.069783034379672 104 6812414
SGTC_1964 st076914 61 µM 1.47584443961047 0.0813800225216348 no 227 0.0699928288411421 123 24208661
SGTC_1268 0828-0275 2.46 µM 1.47132298198705 0.0820258709069173 no 228 0.0706018954842938 107 745337
SGTC_1068 loratadine 26.9 µM 1.46851563482214 0.0824288132452358 no 229 0.0709821062358396 99 3957 A H1 histamine antagonist.
SGTC_586 0957-0265 8.15 µM 1.46666503293075 0.0826952464988362 no 230 0.0712335997370913 117 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2658 polymyxin b sulfate 77.05 µM 1.46582051721332 0.0828170475292805 no 231 0.0713485949971743 107 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_613 3914-0030 117 µM 1.46534015133374 0.0828863889237293 no 232 0.0714140685758578 56 1145395
SGTC_597 k018-0003 82.8 µM 1.45857720143412 0.0838672702288135 no 233 0.0723407561669024 96 6786234
SGTC_2388 9080168 200 µM 1.45816844328699 0.0839268336804601 no 234 0.0723970598236396 101 15943073
SGTC_1818 st052136 56.3 µM 1.45060320123812 0.0850349684077496 no 235 0.0734451916944517 129 674169
SGTC_321 4534-3890 65.3 µM 1.44837201987922 0.0853638702923768 no 236 0.0737565178237912 106 699746
SGTC_995 3931-2021 34.6 µM 1.44754699268994 0.085485729852693 no 237 0.0738718924524739 103 730143
SGTC_636 0kpi-0074 126 µM 1.4395050790251 0.0866803817646498 no 238 0.0750037359894105 97 616434
SGTC_148 3253-0744 288.01 µM 1.43817313563033 0.0868794448065067 no 239 0.0751924677802872 98 6893655
SGTC_703 3875-0075 71.8 µM 1.43355995477217 0.0875715390746376 no 240 0.0758489390496304 122 2850814
SGTC_2314 7727897 200 µM 1.43316588855945 0.0876308491997369 no 241 0.0759052177302468 79 900724
SGTC_3241 9133421 49.47 µM 1.42998893140664 0.0881101019682993 no 242 0.0763600979428249 85 17018221
SGTC_2224 6650123 117.647 µM 1.42843874654687 0.0883446597789984 no 243 0.0765828067096578 98 2908370
SGTC_1612 st002233 45.4 µM 1.42638629283981 0.088655931157522 no 244 0.0768784340526806 105 1035021
SGTC_274 sirtinol 40.1 µM 1.42527867546166 0.0888242493732187 no 245 0.0770383308937939 110 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3285 9112818 20.8695 µM 1.42454293412487 0.088936187183656 no 246 0.0771446829314746 133 17017947 YPR165W RHO1
SGTC_2376 9072922 81.32 µM 1.42413309518566 0.0889985867874767 no 247 0.0772039738610075 106 17087968
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.4190410985311 0.0897765831641698 no 248 0.0779435172363832 100 2374 Ca(2+)-ATPase inhibitor.
SGTC_2939 9044578 71.43 µM 1.41810359156256 0.0899203724775035 no 249 0.0780802614252374 103 2653634
SGTC_3275 9138069 49.47 µM 1.41643922332104 0.0901760650249606 no 250 0.0783234733928774 112 17617007
SGTC_1204 4049-0315 18.3 µM 1.40838201501342 0.0914215124555401 no 251 0.0795089909212747 97 588402
SGTC_1302 1159-0335 255 µM 1.40423567152668 0.0920673835873618 no 252 0.080124341420644 98 649284
SGTC_2470 5664817 21.68 µM 1.40196629452068 0.0924223092732434 no 253 0.0804626559816291 99 2859561
SGTC_3161 9100388 49.47 µM 1.4001449044896 0.0927079023446157 no 254 0.0807349652524237 107 25236368
SGTC_2434 5670830 169.91 µM 1.39909683344855 0.0928725349372979 no 255 0.0808919735841251 114 1549830
SGTC_419 nsc-638432 893 µM 1.39791080799045 0.0930590982172701 no 256 0.0810699263401326 108 368090
SGTC_1102 cgs 12066b 26.1 µM 1.39700893497127 0.0932011492639652 no 257 0.0812054421330033 101 6438352 A 5-HT1B full agonist.
SGTC_1097 itavastatin 7.23 µM 1.39659492503211 0.0932664122388444 no 258 0.081267708637888 125 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1182 1222-0449 220 µM 1.39634324746835 0.0933061022451954 no 259 0.0813055781846751 88 658318
SGTC_550 4123-0385 25.7 µM 1.3935993850758 0.0937396242028578 no 260 0.0817193071622974 108 5731123
SGTC_3057 9095946 49.47 µM 1.39333664819045 0.093781213718909 no 261 0.081759006639078 126 24540043
SGTC_448 monastrol 171 µM 1.39234355305158 0.0939385371774325 no 262 0.0819091943925907 99 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2349 9023730 187.07 µM 1.39039893417489 0.0942471624152079 no 263 0.0822038849748083 99 4126287
SGTC_2222 6885208 172.143 µM 1.38431157072538 0.0952181058140908 no 264 0.0831315362973924 87 609514
SGTC_2455 5377712 9.75 µM 1.3841717472078 0.0952404940826371 no 265 0.0831529360641129 104 2243908
SGTC_174 3553-0389 74.3 µM 1.38361964350731 0.0953289337180931 no 266 0.0832374751280324 100 738071
SGTC_508 roscovitine 141 µM 1.38032830247702 0.0958574174324511 no 267 0.0837427922594394 125 160355 A CDKinase inhibitor.
SGTC_755 1995-0008 37.3 µM 1.37595260969707 0.0965633458406219 no 268 0.0844181528536133 76 689533
SGTC_823 0417-1665 178 µM 1.37581161880422 0.0965861551760036 no 269 0.0844399816704457 117 3429856
SGTC_308 4092-1169 104 µM 1.37529634559498 0.0966695491141485 no 270 0.0845197945078348 127 2268590 YDL196W YDL196W
SGTC_2734 clemastine 41.6 µM 1.37089141939741 0.0973846199545965 no 271 0.0852044032950234 116 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_551 k048-0028 34.9 µM 1.36704150307873 0.0980127647563808 no 272 0.0858061485024518 133 6836383
SGTC_3140 9094243 49.47 µM 1.36677360770936 0.0980565842691307 no 273 0.0858481388523838 125 19291112
SGTC_983 1491-0821 12.2 µM 1.36651139851725 0.0980994875957941 no 274 0.0858892528333013 103 46495113
SGTC_583 1488-1091 88.9 µM 1.36556861012119 0.0982538626286156 no 275 0.0860372022912669 139 4303273
SGTC_17 0960-0276 49.807 µM 1.36424924530383 0.0984701980672854 no 276 0.0862445669831601 130 6821114
SGTC_2552 juarezic acid 87.02 µM 1.36247819866525 0.0987611435113755 no 277 0.0865235099195561 99 1549512
SGTC_2165 5727197 32.143 µM 1.3624169696523 0.098771213379795 no 278 0.0865331656435748 115 1361712
SGTC_1683 st010134 710 nM 1.3615058541556 0.0989211463792643 no 279 0.0866769423896427 112 3818134
SGTC_1821 st053465 65.6 µM 1.35863014317198 0.099395464921944 no 280 0.0871319092129205 95 675086
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.34945714334802 0.100919562151064 no 281 0.0885950885001646 161 16725076
SGTC_2005 4024620 188 µM 1.34749463439127 0.101247834662702 no 282 0.0889104901799152 122 236743
SGTC_3147 9097027 49.47 µM 1.34490586285422 0.101682052440684 no 283 0.0893278183417169 131 25236841
SGTC_3220 9131269 49.47 µM 1.34325049930072 0.101960418329587 no 284 0.0895954373649203 107 17722206
SGTC_2214 7179297 48.276 µM 1.3426626054115 0.102059411879597 no 285 0.0896906242146068 93 769744
SGTC_931 2812-0076 566 µM 1.33755912785693 0.102921709751557 no 286 0.0905200977649659 126 3450959
SGTC_342 k048-0088 23.3 µM 1.33629056688761 0.103136868360699 no 287 0.0907271592830272 123 6820570
SGTC_914 3820-6779 408 µM 1.33480930729272 0.103388515622596 no 288 0.0909693832553577 103 2893481
SGTC_2987 9018338 71.43 µM 1.33372378505881 0.103573214912107 no 289 0.0911471983771194 145 5055682
SGTC_1826 st055655 41.6 µM 1.33317182557423 0.103667221416186 no 290 0.0912377114776971 116 676168
SGTC_2387 9077560 195.08 µM 1.33250712195645 0.10378051198778 no 291 0.0913468013657513 113 5303272
SGTC_2990 9074105 71.4286 µM 1.33170493411419 0.103917354621448 no 292 0.0914785836303894 115 6502001
SGTC_3122 9126309 49.47 µM 1.32878869300681 0.104415929298536 no 293 0.0919588467987097 133 17591206
SGTC_1873 rapamycin 2 nM 1.3277287437321 0.104597572155783 no 294 0.0921338671434841 108 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_960 1222-0186 7.7 µM 1.32529486621074 0.105015530242626 no 295 0.0925366855363415 128 3126296
SGTC_1940 st075990 51.1 µM 1.32486965248173 0.105088674029905 no 296 0.0926071939404386 118 1084979
SGTC_2033 5192550 145 µM 1.32336934667108 0.105347045968031 no 297 0.0928562902365183 110 182073
SGTC_132 0417-1715 25.805 µM 1.32267132995799 0.105467409927673 no 298 0.0929723509122449 118 6769098
SGTC_432 NS 1619 61.3 µM 1.31981785209999 0.105960489705385 no 299 0.0934479198806691 119 4552 A K+/calcium channel activator.
SGTC_644 1498-1197 63.3 µM 1.3195757067765 0.106002408868852 no 300 0.0934883590854578 130 6741615
SGTC_2673 kobusone 100 µM 1.31858982261456 0.106173204636538 no 301 0.0936531389932965 126 6710676 An epoxy ketone and protein crosslinker.
SGTC_275 trichlorophene 5.69 µM 1.31718036904845 0.106417725198967 no 302 0.0938890862594053 103 62616
SGTC_325 2810-4341 181 µM 1.31176182762643 0.107361552820685 no 303 0.0948002541481619 110 774970
SGTC_719 2810-4230 27.3 µM 1.30966515771883 0.10772837534588 no 304 0.0951545677050992 103 721079
SGTC_1981 st071826 47 µM 1.30774366739029 0.108065341467616 no 305 0.0954801334209945 128 11838600
SGTC_1699 st031318 29.054 µM 1.30735574108296 0.108133462932873 no 306 0.0955459606619368 130 5340658
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.30531901053008 0.108491628493814 no 307 0.0958921216846039 109 6312947
SGTC_870 0573-2213 57.6 µM 1.30038053875367 0.109363616198409 no 308 0.0967352883243854 113 3916321
SGTC_1632 st005650 90 µM 1.30016189135629 0.109402338892147 no 309 0.0967727444111237 122 2759605
SGTC_966 1300-0360 30.2 µM 1.29982412778717 0.109462176545788 no 310 0.0968306270046053 156 70588
SGTC_2874 9043904 71.43 µM 1.29621535515699 0.110102968520835 no 311 0.0974506504023798 135 4463428
SGTC_1949 st076024 69.1 µM 1.29591717382642 0.110156035222813 no 312 0.0975020109017164 131 2921930
SGTC_341 1486-1430 230 µM 1.29443121142927 0.110420762346933 no 313 0.0977582577817027 172 2054753 YPL210C SRP72
SGTC_616 4092-0450 108 µM 1.29246989693857 0.110770872300017 no 314 0.0980972321831455 125 787165
SGTC_2731 amoxapine 43.43 µM 1.28861722004641 0.111460919529862 no 315 0.0987655969098146 124 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2728 chlorpromazine 9.18 µM 1.28085081560191 0.112861288101866 no 316 0.100123035673628 120 2726 A thorazine and dopamine antagonist.
SGTC_1150 3909-7983 10.9 µM 1.28021485781205 0.112976512203978 no 317 0.10023479095552 149 23965914
SGTC_630 4356-0227 183 µM 1.28002832694193 0.113010324158804 no 318 0.100267586824802 160 779312
SGTC_981 1488-1094 54.9 µM 1.2790569966712 0.113186511338798 no 319 0.100438492761136 123 3449522
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.27655159858583 0.113641863699167 no 320 0.100880299541494 115 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2079 5212404 121 µM 1.27501767834037 0.113921295142565 no 321 0.101151492419805 107 758462
SGTC_2290 7904846 200 µM 1.27190684372085 0.114489492648025 no 322 0.101703109984131 128 2962154
SGTC_295 k015-0027 31 µM 1.27175195761343 0.114517835398868 no 323 0.101730631731656 104 3887424
SGTC_1943 st076331 65.2 µM 1.27077754713412 0.114696258210734 no 324 0.101903899312105 121 24208415
SGTC_2904 7225135 42.03 µM 1.26462844651501 0.115826774110094 no 325 0.103002275404588 167 4446116
SGTC_6 0844-0013 19.835 µM 1.26176259115897 0.116356358049003 no 326 0.103517113436171 167 1584900
SGTC_312 4092-0653 6.84 µM 1.25618729014249 0.11739153955829 no 327 0.104524036876906 155 1148278
SGTC_1072 oxiconazole 14.9 nM 1.25357193297365 0.117879380846132 no 328 0.104998819072202 148 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1669 st015249 58.4 µM 1.25273571743497 0.11803566192321 no 329 0.105150951386326 115 722793
SGTC_2168 5727979 200 µM 1.24991856602841 0.118563240245706 no 330 0.105664648264317 127 695210
SGTC_569 4130-2812 160 µM 1.24823147531655 0.118879984583421 no 331 0.105973150219738 121 743552
SGTC_1768 st044301 37.178 µM 1.2474615719604 0.119024729190741 no 332 0.106114151081587 165 3931349
SGTC_560 2332-1943 155 µM 1.24605859568518 0.119288813685888 no 333 0.106371441975796 131 21177716
SGTC_591 4299-0174 154 µM 1.24199204345534 0.120056602900173 no 334 0.107119748845678 130 5509088
SGTC_3079 9117512 49.47 µM 1.24184201024219 0.120084996528742 no 335 0.107147429650524 166 7185044
SGTC_674 0498-0004 451 µM 1.24114245992406 0.12021744816842 no 336 0.107276563275258 159 4231473
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.24083021202186 0.120276601856648 no 337 0.107334238941555 148 279621
SGTC_2464 5717415 7.67 µM 1.23762471691715 0.120885051651757 no 338 0.107927622605602 129 5285744
SGTC_2889 9059656 51.95 µM 1.23756962822699 0.120895527188268 no 339 0.107937840929005 135 3949838
SGTC_1462 k081-0014 26.5 µM 1.23689170799421 0.121024491217594 no 340 0.108063644438861 108 3270634
SGTC_2802 7925815 54.55 µM 1.23640283064554 0.12111755275541 no 341 0.108154432235198 137 1262923
SGTC_2047 4141938 200 µM 1.23638769938188 0.121120433909924 no 342 0.108157243087888 139 3807862
SGTC_3035 9091303 49.47 µM 1.23476048607167 0.121430554148215 no 343 0.108459828641903 129 25237002
SGTC_2869 9037858 32.47 µM 1.23433796589791 0.121511170796753 no 344 0.108538497137816 128 27187042
SGTC_2580 diallyl disulphide 81.36 µM 1.23229240610507 0.121901994580625 no 345 0.108919937743367 140 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2163 5671233 125 µM 1.23228360137404 0.121903678715109 no 346 0.10892158166364 143 701023
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.23227346117405 0.121905618313115 no 347 0.108923474949742 125 364106
SGTC_1431 4049-0260 9.09 µM 1.23218495114028 0.121922549263046 no 348 0.108940001744363 151 3854841
SGTC_1864 st057645 30.4 µM 1.23085023496689 0.122178065362885 no 349 0.109189441557998 140 688666
SGTC_1725 st036284 20.55 µM 1.23064165934467 0.12221802871472 no 350 0.10922845847598 128 707914
SGTC_2992 9074591 71.4286 µM 1.22957655823697 0.122422246508675 no 351 0.109427856369172 126 17741321
SGTC_2800 7887935 81.82 µM 1.22876592611371 0.122577833943612 no 352 0.109579790161912 137 2961002
SGTC_2732 terfenadine 20 µM 1.22818624057762 0.122689180039571 no 353 0.109688531335864 148 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1550 gossypolone 36.6 µM 1.22723458840412 0.122872127353326 no 354 0.109867216368025 137 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3273 9137859 49.47 µM 1.22710528091981 0.122897000409342 no 355 0.109891511636302 158 2377234
SGTC_220 paclitaxel 373.376 µM 1.22527081281202 0.123250251521075 no 356 0.110236600801407 120 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1153 4055-0057 267 µM 1.22034495582852 0.12420230876121 no 357 0.111167067188366 153 882706
SGTC_2964 9083345 53.42 µM 1.21988993953755 0.124290512016229 no 358 0.111253300056046 147 17741579
SGTC_2681 menadione 3.18 µM 1.21976238482457 0.124315245894176 no 359 0.111277482306895 146 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2106 5357045 167.29 µM 1.21927960387037 0.124408892149333 no 360 0.111369043615153 143 668842
SGTC_1232 0279-0259 161 µM 1.21611864725238 0.12502324981297 no 361 0.111969864027755 143 1560000
SGTC_707 0865-0008 204 µM 1.2153391408102 0.125175078413658 no 362 0.112118384685799 148 723043
SGTC_3113 9123498 49.47 µM 1.21399866063327 0.125436471827705 no 363 0.112374117806373 150 8897275
SGTC_2867 9039098 71.43 µM 1.21382984153798 0.125469418515664 no 364 0.112406354174573 143 6463460
SGTC_3102 9121669 49.47 µM 1.20929469546394 0.126356757491772 no 365 0.113274824028815 148 41905072
SGTC_2394 5221648 200 µM 1.20728368653084 0.126751624192584 no 366 0.113661455508951 163 788586
SGTC_709 3807-1509 243 µM 1.20699135253887 0.126809096164001 no 367 0.113717737124062 163 1886677 YPL242C IQG1
SGTC_499 genistein 192 µM 1.20511262997068 0.127178880261964 no 368 0.114079912359576 118 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_259 usnic acid 108.925 µM 1.20287785623843 0.127619721162571 no 369 0.11451179528744 162 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_760 0568-0725 82.9 µM 1.20250279853636 0.127693810609125 no 370 0.114584391252597 148 3916171
SGTC_2733 amorolfine 100 µM 1.1994805249848 0.128291926166811 no 371 0.115170576468731 161 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1547 harmine 94.2 µM 1.19914472459518 0.128358501790075 no 372 0.115235838015191 155 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1477 0139-0234 16 µM 1.19885536240916 0.128415889834359 no 373 0.115292095554173 144 620880
SGTC_162 k030-0015 37.8 µM 1.19850826374546 0.128484752017235 no 374 0.115359603917912 157 1809920 YMR134W ERG29
SGTC_1449 4112-4002 201 µM 1.19770690706591 0.128643834008177 no 375 0.115515569713807 125 2059539
SGTC_1782 st039423 80.636 µM 1.1969975575287 0.128784765119595 no 376 0.115653753377571 130 2068169
SGTC_2484 5809818 12.04 µM 1.19692335936281 0.128799512739716 no 377 0.115668214209218 136 2870548
SGTC_460 trequinsin 123 µM 1.19651528691513 0.128880642118737 no 378 0.115747768335766 147 5537 A vasodilator.
SGTC_984 1492-0255 2.91 µM 1.19552699108858 0.129077273263914 no 379 0.115940598586953 138 1585198
SGTC_3078 9116413 49.47 µM 1.18783858189551 0.130614061384698 no 380 0.117448505388297 144 17177322
SGTC_3115 9123671 49.47 µM 1.18265163172225 0.13165796746466 no 381 0.118473620415775 153 3286988
SGTC_2227 7312221 64.1025 µM 1.18151767960111 0.131886947233264 no 382 0.118698567160413 165 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_224 benfluorex 43.875 µM 1.17447276146516 0.13331568678058 no 383 0.120102857984476 137 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_691 1548-0686 185 µM 1.17396868016846 0.133418323299279 no 384 0.120203785428053 177 46495133
SGTC_60 0986-0278 202 µM 1.17136810608034 0.133948692346555 no 385 0.120725423237359 138 3110598
SGTC_2924 9010168 62.78 µM 1.17121284446305 0.133980402644463 no 386 0.120756616818034 137 2993929
SGTC_880 0833-0487 87.2 µM 1.1707289754851 0.134079260087772 no 387 0.120853867227968 146 76075
SGTC_912 3474-0017 2.18 µM 1.17008855012525 0.134210180014832 no 388 0.120982667859578 142 3360550
SGTC_1348 1493-0373 93.8 µM 1.1700199138019 0.134224216307162 no 389 0.120996477541068 155 3010129
SGTC_2425 5628681 7.85 µM 1.16945156046851 0.134340484666368 no 390 0.121110873289653 146 5714958
SGTC_1249 0481-0015 10.2 µM 1.16375004053178 0.135510674831367 no 391 0.122262661887588 165 4227577
SGTC_1836 st055642 81 µM 1.16321115250973 0.135621637345755 no 392 0.122371921380283 180 8571
SGTC_2922 7999257 32.47 µM 1.15656009928669 0.136996282400527 no 393 0.123726066019265 148 2988377
SGTC_3135 9127742 49.47 µM 1.1564633911601 0.137016340089353 no 394 0.123745832729008 145 3643468
SGTC_2026 5148700 152 µM 1.15634802491955 0.137040270177272 no 395 0.123769415965809 155 79838
SGTC_1707 st032323 6.317 µM 1.15379662030898 0.137570230710494 no 396 0.124291780056443 162 3132057 YMR211W DML1
SGTC_835 0312-0010 67.2 µM 1.15199282526177 0.137945745903233 no 397 0.124662010811842 160 1626196
SGTC_1412 3909-8563 178 µM 1.15034237140757 0.138289950452223 no 398 0.125001442826713 167 23767530
SGTC_177 1327-0068 8.361 µM 1.1447969144181 0.139450749458828 no 399 0.126146646912861 163 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_77 0828-0286 12.516 µM 1.14476484473281 0.139457481642284 no 400 0.126153290891896 134 745345
SGTC_2903 5923464 63.88 µM 1.14345768377143 0.139732073719414 no 401 0.12642430721601 154 2876576
SGTC_2655 perillic acid 100 µM 1.14145315567281 0.140153873609934 no 402 0.126840697613055 147 5702197 An apoptosis inducer.
SGTC_2727 riluzole 51.77 µM 1.13934238524653 0.140598963420372 no 403 0.127280188189743 160 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_504 lovastatin 124 µM 1.13902276202761 0.140666444650614 no 404 0.127346830246508 158 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2635 hydroquinidine 100 µM 1.13858234447337 0.140759464884839 no 405 0.127438697910385 123 442912 An experimental heart treatment.
SGTC_1093 fluphenazine 7.97 µM 1.13711873345605 0.141068892769187 no 406 0.127744326782379 167 6602611 An atypical antipsychotic.
SGTC_2166 5933061 31.504 µM 1.13536549513894 0.141440158746998 no 407 0.128111105331211 142 2877375
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.13336895141474 0.141863752817999 no 408 0.128529673532416 147 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1080 nisoldipine 24.4 µM 1.13032025671253 0.142512230958861 no 409 0.12917065098651 166 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2159 5658611 73.75 µM 1.1299927957588 0.142582003179128 no 410 0.129239630075727 145 793844
SGTC_2098 5376439 882.5 nM 1.12870170276007 0.142857321875388 no 411 0.129511845378003 150 2844116
SGTC_2712 st079126 47.7 µM 1.12808243070707 0.14298950576111 no 412 0.129642554161675 154 3152970
SGTC_2883 9059145 45.46 µM 1.12738583591817 0.14313829295714 no 413 0.12978969249859 184 16476510
SGTC_1166 k206-0078 225 µM 1.12645437409615 0.143337409283241 no 414 0.129986621293992 158 5404595
SGTC_2775 cyproheptadine 69.59 µM 1.12457789912645 0.143739106481104 no 415 0.13038397168909 147 2913 A selective serotonin reuptake inhibitor.
SGTC_841 0251-0215 91.2 µM 1.12391875445103 0.1438803897559 no 416 0.130523747161913 160 3888614
SGTC_667 1498-1044 59 µM 1.12113324342782 0.144478479689739 no 417 0.131115575053254 161 6739982
SGTC_1108 betulinic acid 729.144 nM 1.11997656895996 0.144727326158384 no 418 0.131361873539949 142 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_753 1322-0200 289 µM 1.11838484239796 0.145070241247937 no 419 0.131701332603671 136 5403907
SGTC_1286 0929-0070 131 µM 1.11618026731488 0.145546088481085 no 420 0.132172489629492 168 1420408
SGTC_3171 9103192 49.47 µM 1.10791230063076 0.147340031947338 no 421 0.133949846371611 155 13018434
SGTC_2450 5739737 12.93 µM 1.10732369660445 0.147468307015827 no 422 0.134077001310089 155 2262825
SGTC_3267 9137951 49.47 µM 1.10663147374513 0.147619259556348 no 423 0.134226646896193 171 16643986
SGTC_549 1661-1316 519 µM 1.1058051244165 0.147799596438099 no 424 0.134405438268934 178 2857282
SGTC_1189 1431-2119 7.28 µM 1.10535991294777 0.147896817496511 no 425 0.134501833284616 168 3107275
SGTC_714 4296-0578 26.1 µM 1.10531818810291 0.147905931166148 no 426 0.13451086977629 168 1589775
SGTC_3325 9138760 55.175 µM 1.10509940161741 0.147953725340991 no 427 0.134558259932362 140 43844959
SGTC_2178 5812956 200 µM 1.1021510961448 0.148598794576741 no 428 0.135197994318783 157 5403383
SGTC_963 1269-2853 151 µM 1.10200915947431 0.148629896725355 no 429 0.135228844793515 147 3668223
SGTC_2058 5236698 133 µM 1.10155515899761 0.148729409682692 no 430 0.135327555928196 152 766665
SGTC_348 k064-0012 10.7 µM 1.09939357461933 0.1492038208612 no 431 0.135798216101003 165 5066323
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.09917093050322 0.149252742755949 no 432 0.135846757903633 160 97141
SGTC_2951 9072950 58.06 µM 1.0976689650831 0.14958305149196 no 433 0.136174533135523 176 16488155
SGTC_2414 st077232 92.9 µM 1.09654774367123 0.14982994564805 no 434 0.136419570822528 128 729801
SGTC_3304 9125678 46.087 µM 1.0963560670761 0.149872180229138 no 435 0.136461491014865 168 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1052 3253-3998 198 µM 1.09375162636216 0.150446837188633 no 436 0.137031962561408 148 5450317
SGTC_1225 1216-0074 20.6 µM 1.09348072658118 0.150506694057076 no 437 0.137091393339228 156 4241466
SGTC_480 am 92016 50 µM 1.09345791948116 0.150511734141221 no 438 0.137096397630399 194 2129 K+ channel blocker.
SGTC_1084 voriconazole 435 nM 1.09343604545501 0.150516568133319 no 439 0.137101197305496 177 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_233 rapamycin 362 pM 1.09073863856635 0.151113467107093 no 440 0.137693951809144 169 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2270 7924575 90.91 µM 1.08959661156323 0.151366655862027 no 441 0.137945438177593 163 1262135
SGTC_2419 paclitaxel 166.5 µM 1.08597236206612 0.152172023633727 no 442 0.138745610040154 177 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2842 9000675 19.48 µM 1.08312428917834 0.152806905134629 no 443 0.139376629597256 177 2989072
SGTC_2564 betulinic acid 100 µM 1.0810167068161 0.153277848664997 no 444 0.139844841036317 155 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2154 5570129 200 µM 1.07935167047953 0.153650583673248 no 445 0.140215493464157 169 673366
SGTC_3070 9117005 49.47 µM 1.07890801024241 0.153750002621715 no 446 0.140314368807616 130 8779016
SGTC_2319 6033012 152.6 µM 1.07728840368616 0.154113298468333 no 447 0.140675720660294 175 847246
SGTC_2653 dihydrofissinolide 100 µM 1.07626408118985 0.154343358357149 no 448 0.140904583902474 155 6857746
SGTC_1112 tnp00069 1.16933 µM 1.07132971609634 0.155454782838896 no 449 0.142010601421651 164 145826
SGTC_1810 st050138 53 µM 1.06976006768797 0.155809437343704 no 450 0.142363660438168 199 3444541
SGTC_1349 flufenamic acid 69 µM 1.06910175057937 0.155958339592262 no 451 0.142511911467027 176 3371 A non-steroidal anti-inflammatory.
SGTC_2370 9071495 200 µM 1.06891651133656 0.156000255057815 no 452 0.142553645602897 176 21791103
SGTC_365 0121-0052 13.6 µM 1.06890989588324 0.1560017521231 no 453 0.142555136207891 155 3101739
SGTC_1511 0906-3109 28.5 µM 1.06700892393047 0.15643233098261 no 454 0.142983903112685 174 2882180
SGTC_3134 9127454 49.47 µM 1.06587786797262 0.156688891346975 no 455 0.143239427452115 152 24262820
SGTC_1887 st057648 70.8 µM 1.06501014329029 0.156885907231171 no 456 0.143435669823613 185 688672
SGTC_138 0850-0259 40.9225 µM 1.0649678334632 0.156895517794007 no 457 0.143445243143703 187 6813004
SGTC_377 3970-0964 33.1 µM 1.06442659186952 0.157018493529208 no 458 0.143567746342097 161 16481235
SGTC_2969 9091408 28.7 µM 1.06393563838191 0.157130098108009 no 459 0.143678928524481 151 4286311
SGTC_5 0352-0601 109.883 µM 1.06333397382766 0.157266940881952 no 460 0.143815261744954 149 762456
SGTC_1957 st077035 62.4 µM 1.06213490486476 0.15753989110649 no 461 0.144087223078646 161 705593
SGTC_736 0958-0254 92.6 µM 1.06033793752371 0.157949526489382 no 462 0.144495442907458 180 6812352
SGTC_897 1000-0139 31.4 µM 1.05789136573274 0.158508368509311 no 463 0.14505248601493 169 6151020
SGTC_3288 9119690 36.221 µM 1.05618779452845 0.158898260459269 no 464 0.145441212968786 186 17595618 YKL019W RAM2
SGTC_1956 st077085 54 µM 1.05555664130141 0.159042870302429 no 465 0.145585409484768 196 24208685
SGTC_1389 3405-0187 19 µM 1.05488537874106 0.159196764586743 no 466 0.145738875038543 168 799890
SGTC_647 0140-0236 81 µM 1.05420347465622 0.159353198390213 no 467 0.145894884788482 170 990837
SGTC_1109 tnp00067 928.257 nM 1.05319746865607 0.15958416726936 no 468 0.146125249198036 148 676295
SGTC_2081 5214970 32.255 µM 1.04826479458729 0.160719829021072 no 469 0.147258312515478 139 2063512
SGTC_2972 9093619 59.92 µM 1.04777953221325 0.160831836617922 no 470 0.147370097356606 141 25236256
SGTC_447 ml7 120 µM 1.04243496721602 0.162068832511508 no 471 0.148605030891906 171 4216 Selective myosin light chain kinase inhibitor.
SGTC_818 4072-2707 53.5 µM 1.0403598545513 0.162550781451437 no 472 0.149086372838736 155 882871
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.03935395430788 0.162784738964604 no 473 0.149320075227622 176 4620898
SGTC_2726 cimetidine 79.27 µM 1.03705166946098 0.163321040152365 no 474 0.149855888787866 193 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1133 3473-0247 50 µM 1.03465326916765 0.163880950104305 no 475 0.150415433570412 190 711311
SGTC_2674 ligustilide 100 µM 1.03210628496897 0.164476909340129 no 476 0.151011164958522 170 5319022 A signalling regulator.
SGTC_928 2764-0428 58.7 µM 1.03160496482882 0.164594376601 no 477 0.151128606812512 193 662578
SGTC_3256 9138902 49.47 µM 1.03056925038404 0.164837233057631 no 478 0.151371431057564 193 17228773
SGTC_201 4262-0159 12.803 µM 1.02964265190864 0.16505470037749 no 479 0.151588892739783 170 1341029
SGTC_3206 9114350 49.47 µM 1.02809366964994 0.165418652177124 no 480 0.151952884056973 161 17087243
SGTC_1030 k029-0042 36.7 µM 1.02711795720026 0.165648173739293 no 481 0.152182461987147 166 6080581
SGTC_2923 7992654 58.14 µM 1.02567559710499 0.165987844124668 no 482 0.152522260320813 175 2985126
SGTC_2095 5432005 200 µM 1.02464594030053 0.166230599578421 no 483 0.152765139713649 179 783734
SGTC_1708 st033234 31.827 µM 1.02432014597132 0.166307457710689 no 484 0.152842042722645 174 674664
SGTC_2120 5538279 151.968 µM 1.02292178049964 0.16663760667009 no 485 0.153172415235878 145 2058197
SGTC_1879 gemcitabine 100 µM 1.02248460997857 0.16674090775545 no 486 0.15327579651387 177 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2942 9052777 62.25 µM 1.0222521378822 0.166795856508672 no 487 0.153330789910849 212 6469503
SGTC_428 3448-4153 16.5 µM 1.02207597195148 0.166837504117361 no 488 0.153372472275461 163 3834874
SGTC_1633 st005664 67.9 µM 1.02082024349302 0.167134566775848 no 489 0.153669805797752 165 2063822
SGTC_3050 9093513 49.47 µM 1.01973558222761 0.167391435077699 no 490 0.153926940730824 202 25236664
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.01776488073181 0.167858785079284 no 491 0.154394852758612 174 140250 A respiratory chain inhibitor.
SGTC_1425 4048-4433 7.33 µM 1.0173228241097 0.167963733628773 no 492 0.154499941137463 220 23734946
SGTC_2558 carylophyllene oxide 100 µM 1.01727362002535 0.167975417769362 no 493 0.154511641154124 185 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_261 5-fluorouridine 15.376 µM 1.01627409250306 0.168212881638816 no 494 0.154749441067606 161 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3198 9112019 49.47 µM 1.01570092638023 0.168349149602112 no 495 0.154885913379385 203 45595555
SGTC_2090 5301565 104.445 µM 1.01239935121225 0.169135467787907 no 496 0.155673574222329 190 2056344
SGTC_118 0083-0097 135.343 µM 1.00933924533921 0.169866378972643 no 497 0.156405982342351 222 5207356
SGTC_2216 7189485 200 µM 1.00907597917261 0.16992935499056 no 498 0.156469098514158 175 731273
SGTC_754 3474-0146 171 µM 1.0079142198575 0.170207438695049 no 499 0.15674782224271 174 24762078
SGTC_1915 st067105 30.6 µM 1.00580676845452 0.170712631079228 no 500 0.157254265390686 194 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2265 7929201 200 µM 1.00370813960236 0.171216661278341 no 501 0.157759656286389 216 1265108
SGTC_2560 caryophyllene 100 µM 1.00347492725462 0.171272730854236 no 502 0.157815884175765 190 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1265 0819-1001 68.8 µM 1.00279171291107 0.171437058752661 no 503 0.157980684053388 186 3106768
SGTC_1019 4262-0212 3.4 µM 0.998434963101072 0.172487320777312 no 504 0.159034243378016 201 4677213
SGTC_31 0508-1974 57.237 µM 0.998251157769929 0.172531719924727 no 505 0.159078792580326 166 6810525
SGTC_48 0382-0018 55 µM 0.997696979847056 0.172665628633331 no 506 0.159213159080363 157 762596
SGTC_1172 0370-0043 85 µM 0.997195721973902 0.172786807067597 no 507 0.159334758541831 159 376585
SGTC_2134 5324836 1.464 µM 0.994289318002604 0.173490494363612 no 508 0.160041017331585 182 699272
SGTC_2943 9068529 45.32 µM 0.992919368199889 0.17382281290468 no 509 0.160374625130509 225 3270634
SGTC_1672 st016598 6.51 µM 0.992327910478402 0.173966412087735 no 510 0.160518796235887 190 4665860 YNL267W PIK1
SGTC_207 4185-0010 4.486 µM 0.991511613556411 0.174164723513774 no 511 0.160717912166895 188 3761753
SGTC_555 4296-0685 37 µM 0.991455935296907 0.174178255239596 no 512 0.160731499407831 202 2908540 YHR072W ERG7
SGTC_1318 1280-3875 124 µM 0.990168566143593 0.174491316396741 no 513 0.16104586700925 210 373245
SGTC_721 1187-1332 279 µM 0.989771347829114 0.174587983656813 no 514 0.161142946219799 187 25730
SGTC_782 0083-0095 30.5 µM 0.989755483340598 0.174591845153265 no 515 0.161146824255808 176 3591729 An indicator and reagent.
SGTC_1614 st002383 48.6 µM 0.989211162519399 0.174724368436933 no 516 0.161279919056469 167 1947235
SGTC_952 1185-0122 232 µM 0.988381665486354 0.174926445032746 no 517 0.161482881676602 172 678600
SGTC_750 4073-0104 132 µM 0.988314075604575 0.174942917365965 no 518 0.161499427008544 152 22330957
SGTC_1802 st050112 57.9 µM 0.984867332953684 0.175784227856017 no 519 0.162344620639011 170 4662563
SGTC_3223 9129970 49.47 µM 0.984778753399739 0.175805882837354 no 520 0.162366379570502 204 17248386
SGTC_1387 3342-1166 1.8 µM 0.984592429270856 0.175851438881481 no 521 0.162412154950655 167 3418228
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.983488872569344 0.176121410538765 no 522 0.162683444601275 204 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1134 3477-0009 42.5 µM 0.983435417409622 0.176134494348813 no 523 0.162696593075691 191 3973534
SGTC_3355 9151058 44.0485 µM 0.982974491386623 0.176247337205032 no 524 0.162809996664113 183 17015728
SGTC_1195 1502-0147 41.1 µM 0.981738654308808 0.176550117738035 no 525 0.163114308533512 174 817940
SGTC_3059 1327-0034 3 µM 0.981726971105162 0.17655298169597 no 526 0.163117187162208 176 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2864 9034755 47.6 µM 0.981610934472073 0.176581427889489 no 527 0.16314577926187 171 4930451
SGTC_1319 1306-0155 43.7 µM 0.980149836786177 0.17693986162791 no 528 0.16350608090199 189 3122360
SGTC_172 1112-0046 2.638 µM 0.979665133769497 0.177058869552422 no 529 0.163625721052668 169 2802135 YIL048W NEO1
SGTC_1428 4049-0204 61.7 µM 0.978967548811931 0.177230234589921 no 530 0.163798006990721 205 X1428
SGTC_2423 st077119 87.2 µM 0.978261456008526 0.177403796252445 no 531 0.163972514011093 185 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1990 st072050 59.8 µM 0.97720166663987 0.177664499881393 no 532 0.164234661536738 186 17233948
SGTC_2521 angolensin 13.4 µM 0.975824721038294 0.178003583462833 no 533 0.1645756659595 176 821428 A flavenoid.
SGTC_1003 4049-0218 100 µM 0.975382942152672 0.178112461362326 no 534 0.164685170886801 203 295161
SGTC_2253 7938677 135.83 µM 0.973865696027577 0.178486711393469 no 535 0.165061614169045 162 2301972
SGTC_2512 diallyl trisulfide 49.23 µM 0.973691323029045 0.178529754651691 no 536 0.165104913442194 224 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_509 pifithrin 175 µM 0.971586666877445 0.1790497959628 no 537 0.165628109117338 213 4817 A p53 inhibitor.
SGTC_14 0354-0009 295 µM 0.968222696084199 0.179882979260424 no 538 0.166466581154587 205 1713507
SGTC_3023 9089636 49.47 µM 0.967740021644883 0.180002726801486 no 539 0.166587112506186 187 17249241
SGTC_379 3970-0972 5.9 µM 0.967677666397913 0.180018200273215 no 540 0.166602687693411 190 2898042 YBL034C STU1
SGTC_407 eburnamonine 100 µM 0.965078812842755 0.1806638491624 no 541 0.167252669052157 178 3195
SGTC_2302 7771753 200 µM 0.964474033342113 0.180814306200275 no 542 0.167404160416504 218 2203047
SGTC_1963 st076565 50.3 µM 0.963635751331344 0.181022983834958 no 543 0.167614288048864 204 4914280
SGTC_44 0929-0055 61.211 µM 0.961980517497623 0.181435472213907 no 544 0.16802969526121 207 1379590
SGTC_3317 9138495 8.753 µM 0.961811041794593 0.181477739161769 no 545 0.168072265240479 203 17020139
SGTC_2472 5377652 49.4 µM 0.960999575205381 0.181680202926908 no 546 0.168276190712849 207 1610903
SGTC_2618 avocadyne 43.43 µM 0.960642262493468 0.181769398504236 no 547 0.168366035571438 176 3015189
SGTC_1731 st035964 63 µM 0.959369412974138 0.182087361080954 no 548 0.168686339153288 196 6739575
SGTC_980 1473-0395 201 µM 0.95812632433769 0.182398224676409 no 549 0.16899953137259 219 768876
SGTC_346 4513-0042 7.16 µM 0.957848866887229 0.18246765468325 no 550 0.169069486845588 193 2827372
SGTC_2703 st077852 53.4 µM 0.957262543041082 0.182614428660511 no 551 0.169217378106027 204 6281836
SGTC_364 0083-0097 67.7 µM 0.957216136059733 0.182626048830649 no 552 0.169229087106276 181 5207356
SGTC_3123 9126162 49.47 µM 0.955391283629474 0.183083352466941 no 553 0.16968993012647 182 25239884
SGTC_1206 3978-0017 132 µM 0.954884033345887 0.183210594946721 no 554 0.169818172501752 189 3873677
SGTC_273 hydroxyurea 18.1 mM 0.954765199340752 0.183240412135326 no 555 0.169848224947509 213 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2804 7954240 19.48 µM 0.95361059986871 0.183530275545813 no 556 0.170140394114436 190 828705
SGTC_1513 0337-0559 19 µM 0.952066923487757 0.183918263308788 no 557 0.170531521270938 182 775073
SGTC_2485 5633444 17.78 µM 0.951842241031751 0.183974777570791 no 558 0.170588497879186 194 5724239
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.95049909512217 0.18431284385439 no 559 0.17092935673358 192 15053
SGTC_2232 chlorophetanol 41.5365 µM 0.949548754750411 0.184552275367155 no 560 0.171170793823188 188 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2049 5262831 67.185 µM 0.948272311233056 0.184874170483505 no 561 0.171495421477945 177 763417
SGTC_2321 7390090 138.78 µM 0.948130154047869 0.184910041441053 no 562 0.17153159950913 169 649046
SGTC_2405 ticlatone 3.52 µM 0.947421525377136 0.185088916392138 no 563 0.171712013398404 160 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1367 1812-0510 76.9 µM 0.946841187747605 0.185235487626094 no 564 0.17185985517371 190 1142582 YDR527W RBA50
SGTC_944 3370-0224 231 µM 0.94573188340326 0.18551585625509 no 565 0.172142678026213 163 4580514
SGTC_3191 9110352 49.47 µM 0.943734195491272 0.186021421176151 no 566 0.172652747499113 187 17122424
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.942577769897086 0.186314473577986 no 567 0.17294845742666 212 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.939602889428831 0.187069658096302 no 568 0.173710646809541 198 115019
SGTC_664 1222-0054 14.9 µM 0.938392538430224 0.187377451342769 no 569 0.174021359538501 194 6813991
SGTC_1597 7-benzyloxygramine 47.5 µM 0.938052758576199 0.187463913882159 no 570 0.174108648893267 214 260807
SGTC_1860 st056228 74.6 µM 0.937754689752903 0.187539782667689 no 571 0.174185245607366 216 688679
SGTC_2153 5569715 200 µM 0.934799612065463 0.188292977912881 no 572 0.174945789777124 207 2054701
SGTC_1137 ixabepilone 100 µM 0.932026909491798 0.189001383526905 no 573 0.175661309418412 185 154225 A novel microtubule stabilizer.
SGTC_849 0386-0493 241 µM 0.931680944665058 0.189089890120309 no 574 0.17575071854003 207 726119
SGTC_3239 9133757 49.47 µM 0.93120810575091 0.189210895605432 no 575 0.175872962874347 205 17036923
SGTC_665 3914-0008 307 µM 0.930913957214649 0.189286196003292 no 576 0.175949037061376 201 1069549
SGTC_698 k064-0052 127 µM 0.93041554697903 0.189413828372094 no 577 0.176077986003591 221 5088751
SGTC_615 k087-0205 167 µM 0.929744674400625 0.18958570832155 no 578 0.176251648923598 219 9642773
SGTC_1711 st032263 62.8 µM 0.927001769282188 0.190289448063653 no 579 0.176962807831425 215 3958979
SGTC_2818 7996756 12.99 µM 0.925259867771076 0.190737195011553 no 580 0.177415374424933 238 2241621
SGTC_1784 st039334 36.3 µM 0.925221476420061 0.190747070589939 no 581 0.177425357174064 225 3496984
SGTC_2028 5153890 36.43 µM 0.924195893258239 0.191011002060734 no 582 0.177692166709305 210 2830968 YPR165W RHO1
SGTC_1724 st037281 8.293 µM 0.922549131388871 0.191435260728645 no 583 0.178121107626434 214 574124 YDL195W SEC31
SGTC_3229 9132204 49.47 µM 0.921475593019643 0.191712149296856 no 584 0.178401089095879 185 17682924
SGTC_2180 6301957 200 µM 0.921042775118072 0.191823851652125 no 585 0.178514047462337 200 845462
SGTC_1766 st045414 44.774 µM 0.920999953690953 0.191834905242154 no 586 0.178525225600275 206 253960
SGTC_2383 9036125 200 µM 0.9197116011547 0.192167652877938 no 587 0.178861744278596 191 79580
SGTC_2893 9048488 25.97 µM 0.918855674918844 0.192388911244104 no 588 0.179085533460806 196 6467338
SGTC_1567 st069303 68.4 µM 0.918829670519816 0.192395635862173 no 589 0.179092335287825 210 5581319
SGTC_1316 1272-0050 65.9 µM 0.918798931933523 0.192403584904663 no 590 0.179100375619654 211 7340392
SGTC_3279 9140807 49.47 µM 0.918156911384745 0.192569658235961 no 591 0.179268361667672 208 45595718
SGTC_2528 xanthyletin 44.79 µM 0.918029534337258 0.192602617642247 no 592 0.179301701920134 203 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_351 caspofungin 25 nM 0.916419940740734 0.193019404509317 no 593 0.179723340221896 215 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_673 1082-0474 110 µM 0.91621043272154 0.193073694826005 no 594 0.179778267314794 225 3098046
SGTC_3121 9125696 49.47 µM 0.915924174480748 0.193147888682617 no 595 0.179853333196982 214 1235365
SGTC_2317 5986382 200 µM 0.914899989176096 0.19341348470732 no 596 0.18012206787633 216 877883
SGTC_1439 4092-1168 46 µM 0.914643129272127 0.193480129626523 no 597 0.180189504535799 205 2886240
SGTC_724 3910-0327 137 µM 0.914081501599068 0.193625898441697 no 598 0.180337010907022 222 2885483
SGTC_3245 9134821 49.47 µM 0.9140195813109 0.1936419737688 no 599 0.180353278340348 223 17014901
SGTC_3146 9095609 49.47 µM 0.913156514453033 0.193866122078039 no 600 0.180580115422623 201 17173999
SGTC_1165 k072-0275 30.3 µM 0.912757731401399 0.19396974398022 no 601 0.180684986698109 206 6153523 YGL055W OLE1
SGTC_289 k017-0060 526 µM 0.912506916911796 0.194034934232471 no 602 0.180750965015749 210 5512909
SGTC_1485 3909-9022 254 µM 0.912238917251157 0.194104605905223 no 603 0.180821480689697 220 714516
SGTC_2793 7325131 81.82 µM 0.91095659083353 0.194438182214585 no 604 0.18115912312224 202 4176441
SGTC_95 0471-0001 561.058 µM 0.910782389901796 0.194483524654398 no 605 0.181205021476677 208 4015405
SGTC_1391 3442-0225 151 µM 0.910638681586776 0.194520935071409 no 606 0.181242891137361 200 5227075
SGTC_1516 st013856 110 µM 0.907305457642566 0.195389874592396 no 607 0.182122644449197 199 5281404 A mutagen and neurotoxin.
SGTC_1960 st011366 51.8 µM 0.906812491882732 0.195518585892064 no 608 0.182252981421592 234 3972846
SGTC_1042 0350-0096 82 µM 0.905378829690429 0.195893201616003 no 609 0.182632363644806 204 3122515
SGTC_1105 epirubicin 18.1 µM 0.905060642845454 0.195976402811477 no 610 0.182716630520455 225 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_532 1548-0774 215 µM 0.904173929569756 0.196208378426589 no 611 0.182951590904616 212 5932993
SGTC_3350 9150499 3.57 µM 0.903514879444511 0.196380902244245 no 612 0.183126347426894 225 4910996 YPR165W RHO1
SGTC_2155 5570423 76 µM 0.903158528649635 0.196474224785765 no 613 0.183220882271255 208 797402
SGTC_3302 9125395 16.351 µM 0.903130463869157 0.196481575641813 no 614 0.183228328754719 198 17599668
SGTC_496 calpeptin 138 µM 0.902913637971978 0.196538373293066 no 615 0.183285865958944 190 73364 A calpain inhibitor.
SGTC_3298 9116858 71.43 µM 0.90264076587333 0.196609866410726 no 616 0.1833582916663 223 2506942
SGTC_1352 1496-0991 99 µM 0.901411479762301 0.196932137515992 no 617 0.183684789976849 222 3000039
SGTC_89 0302-0250 142.109 µM 0.901291061132095 0.196963723795155 no 618 0.183716792625417 225 4203518 YLR208W SEC13
SGTC_1484 3473-2379 286 µM 0.900766498062573 0.197101354519876 no 619 0.183856241870616 189 671917
SGTC_124 0136-0217 7.121 µM 0.897512692956959 0.197956361654103 no 620 0.184722701717271 231 3976905
SGTC_3092 9117248 49.47 µM 0.896801471235564 0.198143548344423 no 621 0.184912431387987 227 17141857
SGTC_390 dec-rvkr-cmk 16.7 µM 0.895564904207928 0.198469255160561 no 622 0.185242593437915 197 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_483 fpl-64176 144 µM 0.894810063274759 0.198668235920269 no 623 0.18544431496935 200 3423
SGTC_1504 k297-0033 30 µM 0.892179001655287 0.199362740006616 no 624 0.186148497690924 152 4388117
SGTC_1258 0671-0043 57.1 µM 0.891913241679694 0.19943297211779 no 625 0.186219718274986 220 4298767
SGTC_2677 mitomycin C 100 µM 0.888813924436741 0.200253124673358 no 626 0.187051545578042 226 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.886344102157303 0.200908146771816 no 627 0.18771606535231 216 688664
SGTC_1947 st076332 61.6 µM 0.885821303135992 0.201046963093733 no 628 0.187856914197597 235 24208416
SGTC_776 4476-4378 112 µM 0.885488700208425 0.20113530749307 no 629 0.187946555703083 221 2892008
SGTC_566 0958-0068 16.5 µM 0.884285927216218 0.201454976569022 no 630 0.18827094154309 226 6815365
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.884110829778464 0.20150153876855 no 631 0.188318193812678 195 2724 A muscle relaxant with antifungal properties.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.883486470231916 0.201667621975193 no 632 0.188486744721755 191 16486 A toxic proline analog.
SGTC_2040 5100729 123 µM 0.882967206095708 0.201805811635996 no 633 0.188626995112038 209 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1852 st056254 31.4 µM 0.881912519060135 0.202086665707157 no 634 0.188912058267594 217 442583
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.879825588439012 0.202643086191528 no 635 0.189476900210182 214 6708784 An antioxidant flavonoid
SGTC_2686 alizarin 95.37 µM 0.87681598608221 0.203447121147532 no 636 0.190293297343462 194 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3263 9137018 49.47 µM 0.876073197708734 0.203645854350536 no 637 0.190495121151066 222 43844957
SGTC_2482 5981709 142.65 µM 0.874701789923034 0.204013078840781 no 638 0.190868092978955 221 877755
SGTC_747 3448-8087 38.7 µM 0.874642259673043 0.204029028299453 no 639 0.190884293128572 206 5168703
SGTC_1375 2910-0797 186 µM 0.873745320186866 0.204269427950955 no 640 0.191128482116222 227 742508
SGTC_1676 st018489 23.4 µM 0.87357926012665 0.204313954222232 no 641 0.191173712456166 220 3696235
SGTC_3228 9131799 49.47 µM 0.872763373161044 0.204532804808904 no 642 0.191396033661921 222 17015818
SGTC_620 0109-0052 432 µM 0.872726289372615 0.204542755344281 no 643 0.191406142393883 238 493037
SGTC_178 4092-0806 87.505 µM 0.872297203934398 0.204657910965522 no 644 0.191523131304204 217 2169044
SGTC_2735 sertaconazole 140 nM 0.871591244141865 0.204847456531335 no 645 0.191715704512003 236 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2897 9048598 12.99 µM 0.870172751253332 0.205228628014873 no 646 0.192103002333032 203 6467404
SGTC_1604 st002052 72.4 µM 0.8675789775235 0.205926704845055 no 647 0.192812429542372 211 6254834 YHR062C RPP1
SGTC_440 fluspirilene 35.1 µM 0.866415062816487 0.20624041300134 no 648 0.193131293289367 215 3396 An atypical antipsychotic.
SGTC_2256 7954252 200 µM 0.86630501922701 0.20627008753268 no 649 0.193161457259241 214 2972920
SGTC_3099 9120367 49.47 µM 0.865547441659056 0.206474445789781 no 650 0.193369194346084 241 24824940
SGTC_2596 sinensetin 100 µM 0.864809973033465 0.20667349478176 no 651 0.193571548198397 220 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_520 3584-0023 682 µM 0.864440324350215 0.206773308811752 no 652 0.193673024591516 221 1340790
SGTC_3353 9151644 39.2805 µM 0.864168379295789 0.206846758731083 no 653 0.193747699975028 202 4909158
SGTC_3088 9117578 49.47 µM 0.861941386018419 0.207448830488716 no 654 0.194359886611387 229 678341
SGTC_3022 9087993 49.47 µM 0.85721046695979 0.208731275714412 no 655 0.195664289428139 229 17173644
SGTC_839 0122-0028 230 µM 0.856224135306538 0.208999235344328 no 656 0.195936907510321 254 759448
SGTC_235 0330-0087 5 mM 0.855667937838497 0.209150428447564 no 657 0.196090739809722 216 46494818 YHR062C RPP1
SGTC_74 000s-0487 160.283 µM 0.855233220824697 0.20926864391679 no 658 0.196211024204368 215 677548
SGTC_756 0508-1999 28.3 µM 0.854635657861249 0.209431207332668 no 659 0.196376440395972 221 6753853
SGTC_1053 3366-3204 134 µM 0.853659978539078 0.209696794675777 no 660 0.196646707617109 240 3632071 YPR165W RHO1
SGTC_3196 9111891 49.47 µM 0.849143977335152 0.21092866178082 no 661 0.197900591050265 236 18891510
SGTC_3311 9131146 2.8755 µM 0.848610950380848 0.21107433940036 no 662 0.19804890584153 237 4900406 YPR165W RHO1
SGTC_1029 k015-0030 64.7 µM 0.847433490304088 0.211396351165361 no 663 0.198376772018374 225 2208316
SGTC_838 0109-0203 71.4 µM 0.847166940074685 0.211469287237262 no 664 0.198451038916987 214 759422
SGTC_2529 gangaleoidin 93.61 µM 0.846960445185651 0.211525800509963 no 665 0.198508584574606 230 4565183
SGTC_15 0266-0086 27.098 µM 0.846889439725944 0.211545235241636 no 666 0.198528374585479 234 1712902 YIL048W NEO1
SGTC_3112 9123419 49.47 µM 0.8466380430692 0.21161405281183 no 667 0.198598451193693 245 17015854
SGTC_1863 st057641 20.1 µM 0.84658702962173 0.211628018882814 no 668 0.198612672970208 244 3921635
SGTC_2162 5663267 200 µM 0.846108696418608 0.211758999530078 no 669 0.198746054901774 217 6456493
SGTC_3012 9080433 71.4286 µM 0.845654507916226 0.211883412597515 no 670 0.198872754122563 247 17688859
SGTC_1471 k673-0312 37 µM 0.84516592006555 0.212017296197722 no 671 0.199009103636154 225 24099884
SGTC_43 0570-0105 72.5 µM 0.845072749754698 0.212042832486389 no 672 0.199035110935415 224 1114046 YDL195W SEC31
SGTC_1744 st037937 38.9 µM 0.844189500495201 0.212285004386404 no 673 0.199281760370313 230 1016152
SGTC_3077 9117319 49.47 µM 0.842454368603029 0.212761218413378 no 674 0.199766835699096 253 17154678
SGTC_1910 st062352 60.4 µM 0.842198639292108 0.21283145706048 no 675 0.199838387666477 221 2245730
SGTC_2164 5685496 200 µM 0.842166151432457 0.212840381149254 no 676 0.199847478734028 210 759046
SGTC_208 k072-0098 12.366 µM 0.840453508373158 0.213311136158974 no 677 0.200327079212625 234 5948901
SGTC_438 sphingosine 6.67 µM 0.839773147986124 0.213498315493558 no 678 0.200517795877699 204 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_40 0327-0103 19.753 µM 0.836139308357055 0.214499669537978 no 679 0.201538268444788 210 409036
SGTC_1304 1165-0502 251 µM 0.83453614176172 0.214942310579099 no 680 0.201989464948554 233 767425
SGTC_3036 9090181 49.47 µM 0.834230245717874 0.215026829992946 no 681 0.202075625215134 237 25236586
SGTC_1847 st056231 15 µM 0.834050405882099 0.215076528944311 no 682 0.202126290100704 233 5393180
SGTC_463 ikarugamyin 104 µM 0.833987338178305 0.215093959358254 no 683 0.202144059476951 225 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1645 Cervolide 78 µM 0.833907175623454 0.215116115566271 no 684 0.202166646690224 230 23173 A fragrance.
SGTC_3258 9138477 49.47 µM 0.833437906560529 0.215245843885456 no 685 0.20229890181359 238 4970355
SGTC_412 gemfibrozil 100 µM 0.832501548222678 0.215504833568804 no 686 0.202562952324759 206 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3184 9108758 49.47 µM 0.831004298677651 0.215919336896729 no 687 0.202985600477391 243 902885
SGTC_1820 st053765 18.6 µM 0.829606859775784 0.21630662478695 no 688 0.20338054853185 237 3690829
SGTC_1909 st060837 51.5 µM 0.829548203175365 0.216322889736558 no 689 0.203397136243086 232 678937
SGTC_2323 6148992 148.28 µM 0.828910281011194 0.216499825548331 no 690 0.2035775886681 218 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2929 9013348 24.6 µM 0.828808524912986 0.216528056636074 no 691 0.203606381782277 211 2995952
SGTC_2334 9017922 200 µM 0.82725099054567 0.216960442807386 no 692 0.204047407906056 225 3163164
SGTC_1353 1498-1206 8.11 µM 0.82686202872472 0.217068500086647 no 693 0.20415763375376 227 6756808
SGTC_1761 st044296 37 µM 0.826709452442647 0.217110895713835 no 694 0.204200881227342 245 1826700
SGTC_1111 tnp00062 510.699 nM 0.826151915227137 0.21726585653602 no 695 0.204358960539139 221 676306
SGTC_2996 9066192 71.4286 µM 0.826014349006666 0.217304101249853 no 696 0.20439797608586 229 6472854
SGTC_1500 4488-1866 171 µM 0.825274382896578 0.217509885534724 no 697 0.204607916035974 244 2900003
SGTC_2694 st077685 81.9 µM 0.82514226909221 0.217546638162725 no 698 0.204645412280477 208 2838096
SGTC_1167 k781-0610 148 µM 0.825132561713046 0.217549338791711 no 699 0.20464816756834 227 4525169
SGTC_52 0329-0193 875 nM 0.823607437554303 0.217973874276246 no 700 0.205081324282457 231 3739292
SGTC_2259 7964009 200 µM 0.823503546348649 0.218002810930407 no 701 0.205110850656362 210 313134
SGTC_3247 9135149 49.47 µM 0.823033543575977 0.218133747733801 no 702 0.205244459240191 250 8934436 YOR116C RPO31
SGTC_2486 5283202 22.39 µM 0.822908948871943 0.218168465834924 no 703 0.20527988668271 224 1377751
SGTC_1888 azatryptophan 97.5 µM 0.821626789760683 0.218525922230328 no 704 0.205644668699784 193 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1512 0259-0544 12.2 µM 0.81947174805083 0.219127490906459 no 705 0.20625865720664 226 18476
SGTC_3006 9075424 71.4286 µM 0.818918903378793 0.219281967941622 no 706 0.206416341998387 237 7465181
SGTC_1393 3470-5649 58.2 µM 0.818203211780566 0.219482040942453 no 707 0.206620580758606 205 4108395
SGTC_3066 9117245 49.47 µM 0.817464715430539 0.21968859894668 no 708 0.20683145278148 224 17176980
SGTC_1555 citronellol 128 µM 0.816792830036371 0.21987662274729 no 709 0.207023415182824 238 8842 A terpine precursor.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.815274674648013 0.220301810951564 no 710 0.20745755090487 266 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_254 nsc-64875 3.808 µM 0.814184699139403 0.220607369757064 no 711 0.207769574785264 216 56993
SGTC_985 1493-0307 8.71 µM 0.80931023788662 0.221976821391542 no 712 0.209168359416315 238 3278274
SGTC_2241 6772625 37.8075 µM 0.808714480003322 0.222144528351569 no 713 0.20933969863246 229 2285411
SGTC_2018 5133068 143 µM 0.808581779717201 0.222181893576114 no 714 0.209377874312514 253 785362
SGTC_1384 3089-0840 101 µM 0.807443171152904 0.222502645879017 no 715 0.209705601529253 208 1069836
SGTC_2291 7917025 104.35 µM 0.806974055004864 0.222634875249789 no 716 0.209840715544486 223 2964612
SGTC_248 streptozotocin 5.23457 mM 0.804191673146662 0.223420063021486 no 717 0.210643143520529 253 5300 DNA alkylating agent.
SGTC_1470 k295-0292 231 µM 0.803877298316121 0.223508878512096 no 718 0.210733921046172 260 5045612
SGTC_1716 st033144 30.6155 µM 0.803295152844267 0.223673396143719 no 719 0.210902079450649 235 674617
SGTC_2773 thioridazine 9.09 µM 0.803118970243207 0.223723199921113 no 720 0.210952987020762 239 5452 An antipsychotic.
SGTC_2229 7354935 190 µM 0.802769900384216 0.223821894557171 no 721 0.211053871253921 253 318112
SGTC_1829 berberine 14.4 µM 0.802627820827613 0.223862072656047 no 722 0.21109494158111 242 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2333 9017922 200 µM 0.802504627127196 0.223896913418275 no 723 0.211130556446273 237 3163164
SGTC_2385 9074692 200 µM 0.801822172077003 0.224089976288202 no 724 0.21132791557635 221 17046906
SGTC_805 3852-0218 479 µM 0.80160186877567 0.224152319092765 no 725 0.211391648139253 230 6615355
SGTC_2371 9071574 200 µM 0.801494157601172 0.224182803458748 no 726 0.211422812501069 234 45596039
SGTC_215 1287-0124 461.5 µM 0.801433532312789 0.224199962634812 no 727 0.211440354561061 234 5560863
SGTC_1416 3966-0321 25.3 µM 0.800517675475439 0.224459274368335 no 728 0.211705463427032 243 582530 YLR208W SEC13
SGTC_1130 3454-2858 15.9 µM 0.799151424399586 0.224846424925234 no 729 0.212101307196584 256 715628 YIL048W NEO1
SGTC_2517 totarol 10 µM 0.798597869303967 0.225003391910778 no 730 0.212261811763921 223 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2841 9004761 38.96 µM 0.798173391187871 0.225123799674358 no 731 0.212384938242603 214 2991039
SGTC_515 4092-1064 102 µM 0.797687606366827 0.225261642525511 no 732 0.21252589888135 253 717353
SGTC_3167 9103034 49.47 µM 0.796214903469567 0.22567981822852 no 733 0.212953568286614 222 5127859
SGTC_469 w7 172 µM 0.796016235510935 0.225736263828293 no 734 0.213011299405357 231 45115570 A P450 inhibitor.
SGTC_2725 haloperidol 53.21 µM 0.795015214828928 0.22602079559097 no 735 0.213302325884723 250 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1243 0416-0003 5.65 µM 0.794479050812556 0.226173279067953 no 736 0.213458300001404 231 2141977
SGTC_1168 k815-0004 80.5 µM 0.793973173880534 0.226317202268607 no 737 0.213605524309098 252 642433
SGTC_1945 st075991 56.6 µM 0.79366825225429 0.226403978185663 no 738 0.213694293583716 223 1084980
SGTC_821 1114-0266 29.2 µM 0.791819246818786 0.226930578414286 no 739 0.214233039067564 233 3123235
SGTC_1287 0971-0001 34.6 µM 0.79168757504594 0.226968105113269 no 740 0.214271434441858 232 4665869
SGTC_405 ebelactone b 50 µM 0.790497972624506 0.227307302599958 no 741 0.214618502879444 237 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1154 4088-0362 150 µM 0.789275539609825 0.22765615861361 no 742 0.214975489864884 244 6618304
SGTC_1006 4099-6547 255 µM 0.787882341872626 0.228054114452378 no 743 0.215382765412541 256 3146833
SGTC_2136 5328288 199.296 µM 0.784271134267936 0.229087446333662 no 744 0.216440516642112 232 262395
SGTC_828 2074-0507 139 µM 0.78423659264052 0.229097342939693 no 745 0.216450648650845 238 X828
SGTC_2719 novobiocin 32.65 µM 0.78175864379629 0.229807931499819 no 746 0.217178214966724 260 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2294 7971431 200 µM 0.780052549299776 0.230297895853919 no 747 0.217679972379454 262 5741572
SGTC_806 3966-4455 5.86 µM 0.778676489446456 0.230693504513467 no 748 0.21808515441005 241 714982
SGTC_1870 st057514 26.5 µM 0.7782404064542 0.230818954840835 no 749 0.218213650086893 250 5393161
SGTC_2031 5180455 200 µM 0.77733337574505 0.23108000721074 no 750 0.218481054331122 253 29949
SGTC_2993 9054257 71.4286 µM 0.776504346812216 0.231318753963531 no 751 0.218725627629376 255 6470217 YGL055W OLE1
SGTC_689 0833-0039 98 µM 0.775621543203505 0.231573138129936 no 752 0.21898623823707 284 5374726
SGTC_2213 7173844 200 µM 0.774435965731978 0.231915013251871 no 753 0.219336510907972 257 892728
SGTC_1745 st081495 74 µM 0.773762457399641 0.232109352378098 no 754 0.219535638748269 239 13842402 YBL026W LSM2
SGTC_2009 4012297 12.05 µM 0.772601936860657 0.232444430215349 no 755 0.219878998938406 224 45595307
SGTC_3169 9102970 49.47 µM 0.771432034390198 0.232782489027343 no 756 0.220225446682459 248 17027839
SGTC_416 estradiol valerate 100 µM 0.771044784927386 0.232894450042236 no 757 0.220340193281912 264 13791 A steroid.
SGTC_271 rotenone 740 µM 0.770400644865036 0.233080749147719 no 758 0.220531135507552 243 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_441 propafenone 146 µM 0.768895014104014 0.233516532399728 no 759 0.220977818760597 268 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2145 5634607 200 µM 0.768689898840832 0.233575935028401 no 760 0.221038711419627 242 308662
SGTC_476 mead acid 10 µM 0.768578722701492 0.233608135816564 no 761 0.22107172034198 246 5312531 An omega 9 fatty acid.
SGTC_3272 9137413 49.47 µM 0.768087551485373 0.233750426915412 no 762 0.221217586041768 260 17614870
SGTC_1364 1653-0028 37.6 µM 0.762947637061832 0.235242325746275 no 763 0.222747312368108 235 5718652
SGTC_2071 5230951 39.92 µM 0.761867043093802 0.235556643786039 no 764 0.223069680806379 265 1799272
SGTC_1250 0485-0349 40.2 µM 0.761459937087143 0.235675120908087 no 765 0.223191199661629 238 6842794 YDL195W SEC31
SGTC_260 nsc-65238 3.989 µM 0.76085975468754 0.235849847584882 no 766 0.223370419448695 240 3246252
SGTC_2666 tannic acid 100 µM 0.760718650919321 0.235890936450229 no 767 0.223412566171279 266 16134267 A thiamine antagonist.
SGTC_904 1141-0088 396 µM 0.759528580637036 0.236237637190261 no 768 0.223768211914236 266 1378119
SGTC_302 1094-0063 18.9 µM 0.759195847093302 0.236334621947207 no 769 0.223867704982856 255 5440289
SGTC_2826 7992541 19.48 µM 0.758715485884326 0.23647467569176 no 770 0.224011385607279 301 2985066
SGTC_2170 morpholine 200 µM 0.756693388861774 0.237064737313824 no 771 0.224616788254293 247 121171 Reacts with secondary amines.
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.756508017125152 0.237118870499611 no 772 0.224672333745722 241 641818 YHR062C RPP1
SGTC_2364 9055074 200 µM 0.754971492284982 0.237567835565272 no 773 0.225133043702666 241 6470630
SGTC_3037 9091026 49.47 µM 0.754475637723162 0.237712821356073 no 774 0.225281834354123 252 25236398 YIL048W NEO1
SGTC_595 3909-8003 73.7 µM 0.753974788576347 0.237859316805941 no 775 0.225432180244867 261 699517
SGTC_1757 st041620 31.8375 µM 0.753844070071833 0.237897559350161 no 776 0.225471428929979 256 5289815
SGTC_2459 5811157 9.22 µM 0.752991183017614 0.238147159716287 no 777 0.22572760616324 244 2870684 YBR192W RIM2
SGTC_954 1189-0853 2.85 µM 0.752779402200645 0.238209160342515 no 778 0.225791243171481 252 2828194
SGTC_3243 9134147 49.47 µM 0.751783049821366 0.238500969570758 no 779 0.226090768480076 264 24282180
SGTC_1049 3226-0134 66 µM 0.751521424083764 0.238577626299023 no 780 0.226169456106854 237 5702385
SGTC_2181 6316240 54.2555 µM 0.750680617876306 0.238824075048217 no 781 0.226422445176404 257 12779990
SGTC_2806 7952793 58.44 µM 0.750515973008389 0.238872350412049 no 782 0.226472003657298 248 2972490
SGTC_2110 5483698 200 µM 0.750120551463471 0.23898831338133 no 783 0.226591051459877 241 2848765 YHR062C RPP1
SGTC_2721 ifenprodil 61.44 µM 0.74887282817198 0.239354427619045 no 784 0.226966929450282 252 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1572 epiandrosterone 68.9 µM 0.748856229002548 0.239359300308072 no 785 0.226971932336981 231 441302 A steroid.
SGTC_2911 7942208 15.64 µM 0.748578879370504 0.239440724355346 no 786 0.227055532995512 236 1243384
SGTC_3158 9100007 49.47 µM 0.746243223068703 0.240127023839031 no 787 0.22776025114067 253 19297233
SGTC_87 0100-0052 35.5 µM 0.745972327855746 0.240206691891547 no 788 0.227842065693659 265 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2720 fluspirilene 36.88 µM 0.74366071409737 0.240887104026042 no 789 0.228540881151812 254 3396 An atypical antipsychotic.
SGTC_3332 9141069 11.198 µM 0.743013189568731 0.241077887493077 no 790 0.228736847552979 254 17332883
SGTC_2236 dapsone 200 µM 0.742830804969267 0.241131639226688 no 791 0.228792061333016 242 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2299 7976368 114.88 µM 0.74252564634773 0.241221589047201 no 792 0.228884459552024 246 2979718
SGTC_3221 9128209 49.47 µM 0.74240658079664 0.241256690248027 no 793 0.22892051679263 271 16460723
SGTC_1841 st054148 70 µM 0.740492897088775 0.241821235734882 no 794 0.229500484744641 261 675442
SGTC_2824 7998404 51.95 µM 0.740408655521834 0.24184610384602 no 795 0.229526034206628 272 837851
SGTC_1037 k284-1091 78.7 µM 0.740359791962308 0.241860529004968 no 796 0.229540854671423 250 3334711
SGTC_829 1635-0120 117 µM 0.739168604504374 0.242212327414258 no 797 0.229902311227632 273 285054
SGTC_1557 sumaresinolic acid 42.3 µM 0.738894580044287 0.242293295438364 no 798 0.229985506871657 249 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.738760587895317 0.242332892424113 no 799 0.230026193910081 273 65057 A dermal irritant. YDR527W RBA50
SGTC_2437 5741531 144.16 µM 0.738412404319703 0.24243580305541 no 800 0.230131939521259 267 2262990
SGTC_2778 tioconazole 65.09 nM 0.73821629697848 0.242493775803403 no 801 0.230191510563913 259 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_903 1134-0042 114 µM 0.736932525731731 0.242873466359432 no 802 0.230581691566627 266 701009
SGTC_1294 1000-1494 117 µM 0.735973454308061 0.243157332894086 no 803 0.230873426461423 247 712797 YDL207W GLE1
SGTC_3074 9116018 49.47 µM 0.735483629296612 0.243302380770286 no 804 0.231022503234147 305 17027303
SGTC_1266 0828-0227 32.9 µM 0.734928999704127 0.243466675134466 no 805 0.231191367931768 264 3913820
SGTC_792 4534-1957 155 µM 0.734786950504523 0.243508763095907 no 806 0.231234627862456 255 1717904
SGTC_1025 k007-0731 70 µM 0.734589766937518 0.243567193412012 no 807 0.231294686001727 268 6256118
SGTC_1934 st074720 32.6 µM 0.73379698167734 0.243802191489753 no 808 0.231536240204497 259 17250992
SGTC_3227 9130768 49.47 µM 0.73103474660787 0.244621930681905 no 809 0.232378964842364 270 17720899
SGTC_1778 st046819 58.9 µM 0.730557927709045 0.24476358469841 no 810 0.23252460902923 277 671715
SGTC_929 2805-0021 398 µM 0.72955287445051 0.245062311887977 no 811 0.232831768424435 277 3098024
SGTC_3166 9102297 49.47 µM 0.729324761831659 0.245130140010681 no 812 0.232901514448778 257 25237072
SGTC_2569 tetrandrine 100 µM 0.72801820023609 0.24551883388413 no 813 0.233301222576124 246 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_149 3970-0822 46.1 µM 0.726954111378362 0.245835638119766 no 814 0.233627033612555 256 3114250 YBL034C STU1
SGTC_2381 9035592 200 µM 0.726047953374648 0.24610559552586 no 815 0.23390468692655 254 4749657
SGTC_1780 st038448 24.544 µM 0.725496124348499 0.246270071136891 no 816 0.234073860829545 269 728868 YDL195W SEC31
SGTC_3098 9119039 49.47 µM 0.725372615372908 0.246306891721179 no 817 0.234111734182793 265 17161528
SGTC_1905 st060207 84.5 µM 0.725264845965119 0.246339022425089 no 818 0.234144783855639 248 1948547
SGTC_1781 st038725 66.3 µM 0.725157392403871 0.246371061198268 no 819 0.234177739239706 272 4270275 YIL048W NEO1
SGTC_626 0214-0009 33 µM 0.724703961487759 0.246506282523194 no 820 0.234316832151857 268 3437874
SGTC_2697 mebhydrolin 72.4 µM 0.724353230713687 0.246610904070744 no 821 0.234424452476948 271 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_516 3992-2719 87.3 µM 0.721817570711616 0.247367988037183 no 822 0.235203322615013 249 5350887 YDR037W KRS1
SGTC_1241 0364-0022 50.8 µM 0.721424613352898 0.247485426250648 no 823 0.235324153759089 262 4563895
SGTC_2784 7567673 72.73 µM 0.719689405351771 0.248004362031433 no 824 0.235858125423784 258 3471247
SGTC_2171 5739187 198.077 µM 0.71958419844239 0.248035844138668 no 825 0.235890521971979 260 2262761
SGTC_2037 5169046 200 µM 0.719005453781519 0.248209065764557 no 826 0.236068779682779 248 5718022
SGTC_2878 9043973 25.97 µM 0.718361493980226 0.248401882459508 no 827 0.236267211349863 272 6465167
SGTC_1490 4089-0339 670 nM 0.717599503485045 0.24863014340221 no 828 0.236502131939097 263 742542
SGTC_409 arachidonic acid 100 µM 0.715822919925651 0.249162768220055 no 829 0.237050349037063 264 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1539 benzyladenosine 56 µM 0.71559981548188 0.249229698433131 no 830 0.23711924379579 243 92208 A nucleotide analog.
SGTC_375 3970-0961 9.27 µM 0.715037133677771 0.249398542603145 no 831 0.237293049057951 259 2898222
SGTC_1385 3091-4834 14.1 µM 0.714187998798895 0.249653457929666 no 832 0.237555468443923 255 4072814
SGTC_2966 9084041 48.03 µM 0.713549931340443 0.249845100593707 no 833 0.237752763631403 248 17741380
SGTC_3341 9147222 25.867 µM 0.713035456386585 0.249999679274407 no 834 0.23791190853035 270 1939759
SGTC_1743 st037606 46.3785 µM 0.71132749651047 0.250513215032513 no 835 0.238440658176709 235 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1925 st057770 10.1 µM 0.710826306926335 0.250664014726688 no 836 0.238595938298391 252 5989122
SGTC_2142 5622915 118.518 µM 0.710129476088594 0.250873759520698 no 837 0.238811924542377 266 5322196
SGTC_1014 4130-3005 69.3 µM 0.708532805629228 0.251354704468802 no 838 0.239307223659678 277 743608
SGTC_3192 9110362 49.47 µM 0.703059255532964 0.253007125356953 no 839 0.24100941124711 284 16649480
SGTC_761 k216-0224 480 µM 0.702272335728354 0.253245159206354 no 840 0.241254671078944 291 1340404
SGTC_2603 homopterocarpin 100 µM 0.701202526973918 0.253568952349139 no 841 0.241588316531083 271 101795 A weak amylase inhibitor.
SGTC_2872 9044037 25.97 µM 0.701175567763351 0.253577114753844 no 842 0.241596727640912 262 6465195
SGTC_836 0330-0104 1.35 µM 0.700729765292457 0.253712109791408 no 843 0.241735838352976 264 46494820
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.699048245238824 0.254221636311793 no 844 0.242260940365871 264 4174840
SGTC_1463 k081-0032 34.1 µM 0.698709925244301 0.254324217289887 no 845 0.242366664971526 257 977755
SGTC_955 1216-0110 33 µM 0.698648250311196 0.254342919897083 no 846 0.242385941010307 274 3619719
SGTC_1951 sophoraflavanone G 9.2 µM 0.698587301597749 0.254361402990118 no 847 0.24240499089056 260 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1458 k015-0034 6.33 µM 0.696916208986189 0.254868446819619 no 848 0.242927616628142 278 3598957
SGTC_1126 isoteolin 1.0172 µM 0.695412347494731 0.255325201136769 no 849 0.243398462344345 263 133323
SGTC_2306 7482397 179.52 µM 0.695189771612462 0.255392838437167 no 850 0.243468190749649 287 891448
SGTC_1955 wogonin 32.4 µM 0.694715491869336 0.255536995800598 no 851 0.243616808742106 251 5281703 A flavanone.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.694529131663876 0.255593651629508 no 852 0.243675219073259 258 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1325 1431-0015 227 µM 0.694170127054363 0.255702812002911 no 853 0.24378776214276 256 1103340
SGTC_3276 9139060 49.47 µM 0.693478337393235 0.255913228954957 no 854 0.244004707904272 301 4870619
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.693199774039972 0.255997983183797 no 855 0.244092094985161 296 229346 A bile salt which induces apoptosis.
SGTC_2409 alverine citrate 63.97 µM 0.692836711907711 0.256108468545712 no 856 0.244206015196666 245 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_140 0062-0056 502.533 µM 0.692696701453834 0.256151082512541 no 857 0.244249954785162 260 3758964
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.692140562905439 0.256320386876615 no 858 0.244424530253239 282 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_471 1-acyl-paf 4 µM 0.691025938002631 0.256659885854845 no 859 0.244774620497114 259 16759367
SGTC_693 4161-2696 114 µM 0.690888516024689 0.256701758853106 no 860 0.244817801767463 289 805759
SGTC_1786 berberine 21.6 µM 0.689441387065208 0.257142920380867 no 861 0.24527277311092 281 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2091 4-phenylthiadiazole 200 µM 0.688857922704376 0.257320902665085 no 862 0.245456340383345 271 270010
SGTC_2013 4024628 200 µM 0.688848478570902 0.257323784067499 no 863 0.245459312266626 286 5230760
SGTC_1995 st072814 61.1 µM 0.686538625067715 0.258029022981661 no 864 0.246186758086582 268 5769371
SGTC_3141 9094609 49.47 µM 0.684562436684593 0.258633182804262 no 865 0.246810038690345 290 25236309 YDL196W YDL196W
SGTC_2855 9016525 58.44 µM 0.68371970428536 0.258891045324548 no 866 0.247076089264169 277 43811474
SGTC_711 k292-0785 179 µM 0.682929843992976 0.259132850530616 no 867 0.247325587330304 277 4146315
SGTC_2810 7959871 45.46 µM 0.682672576430699 0.25921163476878 no 868 0.24740688109842 272 2974535
SGTC_78 0336-0123 156.75 µM 0.682391988505124 0.25929757462254 no 869 0.247495560128088 267 6765896
SGTC_723 4182-0001 115 µM 0.68228224370114 0.25933119180748 no 870 0.247530249286597 279 744821 YLR208W SEC13
SGTC_3028 9087778 49.47 µM 0.681924618188441 0.259440755788734 no 871 0.247643308908122 264 17217395
SGTC_1965 Pectolinarigenin 58.4 µM 0.680083164187156 0.260005291338024 no 872 0.248225902006237 284 5320438 An anti-inflammatory.
SGTC_2798 7813637 45.45 µM 0.678330025120309 0.260543340145863 no 873 0.248781232716843 275 956368
SGTC_850 0388-0143 75.9 µM 0.677647666211482 0.260752915031576 no 874 0.248997557909609 279 67273
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.677236355920642 0.260879283850864 no 875 0.249128002105681 279 1377
SGTC_1368 1852-0141 284 µM 0.676879269820402 0.260989018653023 no 876 0.249241278947799 284 2838987
SGTC_193 1273-0060 1.558 µM 0.676235808038998 0.261186818401859 no 877 0.249445470603027 280 2847393 YHR072W ERG7
SGTC_2858 9025781 8.96 µM 0.675976733794965 0.261266479409344 no 878 0.249527708505597 265 4894980 YPL153C RAD53
SGTC_948 3448-0295 75.3 µM 0.674999245612948 0.261567153073509 no 879 0.249838122115849 279 678569
SGTC_3159 9100096 49.47 µM 0.674690422095657 0.261662183559291 no 880 0.249936235487344 266 25236875
SGTC_320 4092-0846 5.34 µM 0.674689105476771 0.261662588744251 no 881 0.249936653821533 282 1359356
SGTC_1203 3992-3522 103 µM 0.674632541390032 0.261679996452591 no 882 0.249954626488955 294 5322312
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.673833926234396 0.261925835238245 no 883 0.250208451576405 262 6857784
SGTC_2448 5185112 27.17 µM 0.673807455367839 0.261933985828251 no 884 0.250216867192663 261 5718189
SGTC_2675 theaflavin digallate 100 µM 0.673275936731866 0.262097672154853 no 885 0.250385879326863 281 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1335 1486-0900 202 µM 0.672854061203505 0.262227630129755 no 886 0.250520070242612 276 X1335
SGTC_2822 7994718 71.43 µM 0.672696380662465 0.262276211802116 no 887 0.250570235329849 311 1018011
SGTC_29 0299-0004 12.984 µM 0.672608554110811 0.262303273327468 no 888 0.250598179110594 268 16871 A napthoquinone isolated from Swertia calycina.
SGTC_553 k007-0256 45.7 µM 0.671762862850686 0.262563924816701 no 889 0.25086733722407 286 6287000
SGTC_701 4424-0219 185 µM 0.671741201133401 0.262570602940633 no 890 0.250874233507221 276 2911779
SGTC_1336 1486-0901 104 µM 0.6714654362444 0.262655626516568 no 891 0.250962035536023 272 5006114
SGTC_1562 morin hydrate 59.1 µM 0.669355484417798 0.263306630815936 no 892 0.251634370495019 280 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3286 9117135 37.221 µM 0.669082743896154 0.263390842246081 no 893 0.251721348496204 275 3438150
SGTC_1233 0325-0408 14.2 µM 0.668961144241629 0.263428391816513 no 894 0.251760132210121 284 12874
SGTC_2189 6047310 154.431 µM 0.668874454278754 0.263455163058259 no 895 0.251787783546649 276 711535
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.668403682910604 0.263600569001697 no 896 0.251937972609266 293 61125 An anti-inflammatory.
SGTC_1880 MG-132 525 µM 0.668370535729585 0.263610808629187 no 897 0.251948549256491 273 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_773 4358-1457 44.6 µM 0.667899214541154 0.2637564282865 no 898 0.252098964407769 306 1186886
SGTC_2790 5423970 71.43 µM 0.667440527440423 0.263898183887496 no 899 0.252245393048158 288 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_226 1,3-diallylurea 8.28947 mM 0.667209155226771 0.263969703372457 no 900 0.252319272000292 276 74537 YKL182W FAS1
SGTC_3174 9107204 49.47 µM 0.666917494216929 0.264059872805325 no 901 0.252412417886028 295 3938802
SGTC_2087 5276107 200 µM 0.665940428152602 0.264362055232101 no 902 0.252724589141781 280 144405
SGTC_1902 st060212 70.5 µM 0.66487411822547 0.264692039357148 no 903 0.253065505553958 268 688944
SGTC_926 2268-1401 59.4 µM 0.664408148124844 0.264836305890841 no 904 0.253214559607277 288 2931578
SGTC_1151 3909-8316 15.3 µM 0.664323651433126 0.264862470744404 no 905 0.253241593269125 289 800431
SGTC_2981 9013952 38.96 µM 0.660134543120283 0.266161295802354 no 906 0.25458374657078 255 2996344
SGTC_309 k408-0051 1.48 µM 0.658024480548763 0.266816735775534 no 907 0.255261200359018 297 3640463
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.657722967643992 0.26691046003187 no 908 0.255358080578366 286 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2440 5628896 157.78 µM 0.654634587518277 0.267871429082512 no 909 0.256351524830374 300 5522048
SGTC_706 4262-0057 46.9 µM 0.653831391134491 0.268121633968067 no 910 0.256610219968602 294 883298
SGTC_1667 st014849 34.6 µM 0.653042807550059 0.26836740118065 no 911 0.256864340791772 278 5348460
SGTC_1455 4262-0120 131 µM 0.652799063200997 0.268443388610658 no 912 0.256942913822317 284 1529587
SGTC_113 0099-0221 2.5 µM 0.652012895521157 0.268688550496932 no 913 0.25719642673868 283 89219
SGTC_528 3492-0019 172 µM 0.65175275749061 0.268769697814592 no 914 0.25728034122265 291 2869262
SGTC_2092 5303694 80.6725 µM 0.651225285114722 0.268934275042806 no 915 0.25745053522619 282 1963699
SGTC_1419 3993-2473 62.6 µM 0.64977960556674 0.269385602299455 no 916 0.257917297214288 293 704026
SGTC_2379 9035213 200 µM 0.646913016594583 0.270281645383437 no 917 0.258844120474198 275 646551
SGTC_1685 st024049 53.0905 µM 0.643005261153583 0.271505533517939 no 918 0.260110343030248 297 1941139
SGTC_2865 9030313 51.95 µM 0.641537789481712 0.271965849699225 no 919 0.260586668464398 285 42562754
SGTC_2135 5326629 150.42 µM 0.640956711455269 0.272148229344644 no 920 0.260775404138232 292 5020077
SGTC_1919 st067113 52.3 µM 0.640474899213152 0.272299499094725 no 921 0.260931951342384 300 1268243
SGTC_488 nitrendipine 139 µM 0.639783702875673 0.272516579993946 no 922 0.261156614592001 286 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3280 9140961 49.47 µM 0.639563524084024 0.272585748589705 no 923 0.26122820135663 307 4901226
SGTC_2233 sulbentine 40.3845 µM 0.639540294368436 0.27259304665275 no 924 0.261235754625616 281 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3335 9143315 29.6265 µM 0.63951588101516 0.272600716682928 no 925 0.261243692881803 275 4899691
SGTC_1461 k072-0203 53.8 µM 0.637858425351932 0.273121695818802 no 926 0.261782921552974 287 5418714
SGTC_46 0329-0187a 2.197 µM 0.637283298096456 0.273302587724515 no 927 0.26197016403776 296 46494817
SGTC_2124 5246320 200 µM 0.635746484613681 0.273786244943432 no 928 0.262470836535143 293 579342
SGTC_482 fipronil 114 µM 0.635528312505215 0.273854941127177 no 929 0.262541953666424 292 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1889 st059080 5.18 µM 0.635332922393088 0.273916471142226 no 930 0.262605652965955 278 176925 Isolated from Daphnopsis sellowiana.
SGTC_2652 actinonin 100 µM 0.634618719511868 0.274141437857684 no 931 0.262838558136385 289 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3109 9122853 49.47 µM 0.633997717203388 0.274337121485919 no 932 0.263041155949679 325 1234709
SGTC_2326 6164455 177.58 µM 0.633710836060659 0.274427543694284 no 933 0.263134775930957 303 2888790
SGTC_3097 9117246 49.47 µM 0.632916113960276 0.274678109331903 no 934 0.263394212170271 273 16423892
SGTC_554 4483-2211 187 µM 0.632782351161871 0.274720294108907 no 935 0.263437891739131 289 747107
SGTC_661 1304-0007 33.6 µM 0.632770381603854 0.274724069104426 no 936 0.263441800518317 297 3117130
SGTC_1131 3454-3128 32.3 µM 0.632723075931941 0.274738988761039 no 937 0.26345724894951 278 710982
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.631566518801336 0.275103877608649 no 938 0.263835085158037 272 6708561
SGTC_796 1234-0020 70.7 µM 0.631214710360634 0.275214918995971 no 939 0.263950072405951 286 46495034
SGTC_712 r015-0009 80.6 µM 0.630682301121784 0.275383005412066 no 940 0.264124136900841 305 6813872 YLR060W FRS1
SGTC_3321 9137793 26.8275 µM 0.630099819941797 0.275566957836984 no 941 0.264314638747746 293 4904192
SGTC_2495 cafestol 54.53 µM 0.629745791630546 0.275678792453794 no 942 0.264430458714905 306 16667697 An anti-infammatory.
SGTC_2534 helenine 20.12 µM 0.629586435387743 0.27572913905424 no 943 0.264482600360843 285 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_329 k048-0121 21.3 µM 0.628207917224962 0.276164853073206 no 944 0.264933872240787 286 6832902
SGTC_2428 5615643 7.78 µM 0.626732577674532 0.276631543908719 no 945 0.26541727269218 316 2253075
SGTC_544 k015-0020 52.4 µM 0.626471564033083 0.27671414998835 no 946 0.265502841349176 294 3008304
SGTC_668 1682-0499 62.6 µM 0.625932004972604 0.276884948943069 no 947 0.265679770499767 299 682214
SGTC_1323 1348-1351 11.2 µM 0.625879100716976 0.276901698714377 no 948 0.265697121781321 290 6989654
SGTC_1356 1502-0781 85.8 µM 0.623414619467917 0.277682516140628 no 949 0.266506046679836 285 567702
SGTC_2457 5731572 11.68 µM 0.62160482234014 0.278256595141175 no 950 0.267100874651671 319 2865357
SGTC_2701 st077767 14.721 µM 0.620877167939304 0.278487574667604 no 951 0.267340222392634 297 5721188
SGTC_2561 acetosyringone 100 µM 0.620497707856662 0.278608063826826 no 952 0.26746508130797 320 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_286 k060-0067 22.9 µM 0.620038218740674 0.278753998410821 no 953 0.267616312621612 282 5985051
SGTC_1933 st074711 15.9 µM 0.619888351474273 0.278801604574699 no 954 0.267665647644906 291 17250958
SGTC_2250 alverine citrate 130 µM 0.619683923231028 0.27886654871318 no 955 0.267732951065594 283 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2516 gossypol 71.55 µM 0.618169617637318 0.279347852582519 no 956 0.268231767665607 306 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2449 5812982 45.77 µM 0.617486397735064 0.279565137874076 no 957 0.268456975234244 296 776185
SGTC_3175 9106517 49.47 µM 0.617066256665092 0.279698796601891 no 958 0.268595512168853 322 41468073
SGTC_145 3737-0113 38.366 µM 0.615353576001218 0.28024396927187 no 959 0.269160621445373 294 6849351
SGTC_2355 9061122 103.12 µM 0.613849454932604 0.280723178353787 no 960 0.269657406722987 316 5302957
SGTC_1978 st071761 42 µM 0.612525515452879 0.281145309734631 no 961 0.270095060879071 291 5147680
SGTC_1148 3909-7663 27.7 µM 0.611162087177748 0.281580352105794 no 962 0.27054613992719 320 4084526
SGTC_1120 ficusin 1.78878 µM 0.607129532500294 0.282868955569249 no 963 0.271882476303297 318 6199 A DNA cross-linker.
SGTC_643 k048-0106 28.4 µM 0.607076094855807 0.282886050572971 no 964 0.271900206868609 302 6763920
SGTC_1502 4534-4282 27.7 µM 0.606208070588662 0.283163805890775 no 965 0.272188297121893 315 3278949
SGTC_1223 0764-0573 147 µM 0.604045934955498 0.283856226601483 no 966 0.272906551454397 296 1609797
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.602872450346569 0.284232372310678 no 967 0.273296772292884 296 688803
SGTC_1011 4112-3381 17.4 µM 0.601005147384179 0.284831403574641 no 968 0.273918278947377 318 2877139
SGTC_1185 1319-0113 81.3 µM 0.60053015044361 0.284983878760948 no 969 0.274076486681105 314 4672763
SGTC_1881 5652484 16 µM 0.596769714649247 0.286192359702022 no 970 0.275330570236797 314 2255129
SGTC_787 4152-0075 138 µM 0.595201917913012 0.286696916158072 no 971 0.275854254218563 298 9566539
SGTC_159 3970-0959 50 µM 0.594442982254644 0.286941312165043 no 972 0.276107933698447 305 6615653
SGTC_236 1509-0011 5.31 µM 0.593841574205132 0.287135050464496 no 973 0.276309039790253 330 3107280
SGTC_2511 berberine 10.47 µM 0.593417841685598 0.28727158933694 no 974 0.276450775730806 311 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2345 9052315 157.45 µM 0.591742232591901 0.287811819804324 no 975 0.277011605746269 302 6469265
SGTC_1675 st018485 24.5 µM 0.591621598975655 0.287850731607679 no 976 0.277052003561651 304 3323024
SGTC_2001 4023502 57.655 µM 0.58992089447854 0.288399578263386 no 977 0.277621842587202 304 108941 YCR052W RSC6
SGTC_2007 4011539 71.82 µM 0.588373637293473 0.288899332987593 no 978 0.278140764407 303 45595301
SGTC_726 3448-4391 34.2 µM 0.587829077278965 0.28907531949116 no 979 0.278323512380797 316 1356692
SGTC_493 zm226600 134 µM 0.587825753025119 0.289076393951464 no 980 0.278324628141228 321 5240098 A potassium channel opener. YCR052W RSC6
SGTC_950 1165-0508 94.1 µM 0.587403201179991 0.289212985811159 no 981 0.278466472192653 311 6148369
SGTC_486 niguldipine 82 µM 0.587399729442991 0.289214108192032 no 982 0.278467637746374 305 1236 A calcium channel blocker.
SGTC_1643 st009866 20.2 µM 0.585877427578258 0.289706451662809 no 983 0.278978943546334 290 3156273 YOR207C RET1
SGTC_3254 9136651 49.47 µM 0.585695669730062 0.289765262133522 no 984 0.279040022284557 330 16454030
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.585385430196453 0.289865657714206 no 985 0.279144291616783 303 75037 A free radical scavenger.
SGTC_627 1391-0720 175 µM 0.585034989116805 0.289979082402822 no 986 0.279262095184539 348 997839
SGTC_2332 7982454 138.89 µM 0.58121451610243 0.291216974743656 no 987 0.280547942727684 329 2981748
SGTC_2912 7964298 10.93 µM 0.580141044717084 0.291565239538751 no 988 0.280909753394127 309 2975850
SGTC_69 0096-0274 206.684 µM 0.579166085343924 0.29188171241109 no 989 0.281238556172882 331 6741392
SGTC_2313 7726885 200 µM 0.576536613445151 0.292736038517263 no 990 0.282126264732032 297 726423
SGTC_2881 9058953 51.95 µM 0.576154133652502 0.292860404434743 no 991 0.282255502037297 264 17122249
SGTC_1617 st002906 78 µM 0.574597144112501 0.293366923171079 no 992 0.282781891988454 324 5150859
SGTC_191 3914-0123 66.505 µM 0.57368818008563 0.293662814246042 no 993 0.283089414122253 329 3144412
SGTC_2433 5607874 27.82 µM 0.57278856540557 0.29395579781293 no 994 0.283393931107552 321 2252428
SGTC_2304 7443016 91.4 µM 0.570747888349733 0.294620899388244 no 995 0.284085275999482 316 939854
SGTC_525 k781-2675 26.7 µM 0.569085522368577 0.295163213610567 no 996 0.284649051441616 314 3651118 YDL195W SEC31
SGTC_1609 st001574 46.4 µM 0.568550673198963 0.295337795315816 no 997 0.284830553904957 332 3960012
SGTC_2787 5284540 71.43 µM 0.56477325271137 0.296572144904567 no 998 0.286114001048566 328 736958
SGTC_2202 7226349 200 µM 0.564772576400021 0.296572366114635 no 999 0.286114231083409 291 844334
SGTC_221 trifluoperazine 10.304 µM 0.563804321910632 0.296889143362337 no 1000 0.286443655081233 320 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1446 4239-0190 62 µM 0.563177082097161 0.297094435756493 no 1001 0.286657153518942 331 1340085
SGTC_99 0109-0120 622.8 µM 0.560922437796548 0.29783290478646 no 1002 0.287425206607877 325 759414
SGTC_3210 9128157 49.47 µM 0.56078761391734 0.297877090487054 no 1003 0.28747116569611 329 17590849
SGTC_1753 st043925 64 µM 0.55861174837459 0.298590597792882 no 1004 0.288213360152797 315 670181
SGTC_343 4130-2827 29.8 µM 0.558095754329701 0.298759915914633 no 1005 0.288389499817155 302 1118244
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.5567140302536 0.299213529157102 no 1006 0.288861414698827 332 5377381
SGTC_2132 5317594 122.667 µM 0.556548444607917 0.299267911077372 no 1007 0.288917993300777 342 794577
SGTC_1208 2323-2347 50.3 µM 0.55573579813879 0.299534866797468 no 1008 0.289195740289244 333 5412760
SGTC_2339 9000433 200 µM 0.555506134611693 0.299610331205914 no 1009 0.289274257625802 303 2988954
SGTC_3110 9122132 49.47 µM 0.555353487553701 0.299660493782848 no 1010 0.289326450124147 290 918317
SGTC_1734 st037168 69.4 µM 0.554675582958876 0.299883311415449 no 1011 0.289558290117248 317 708907
SGTC_1067 clotrimazole 1.36 µM 0.551804120115161 0.300827951054201 no 1012 0.29054128207843 298 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_8 0354-0001 70 µM 0.55149654605785 0.300929214787936 no 1013 0.290646666867988 325 4993152
SGTC_1293 1000-1278 195 µM 0.548936677929208 0.30177260517053 no 1014 0.291524453141939 340 678847
SGTC_3352 9151559 45.5865 µM 0.545191857588347 0.303008307630191 no 1015 0.292810785510116 299 17159339
SGTC_374 0880-0231 82.3 µM 0.544602606863234 0.303202952474203 no 1016 0.293013430723395 322 6833587
SGTC_684 1140-0066 328 µM 0.543883743868576 0.303440487299275 no 1017 0.293260738080646 322 6813534
SGTC_1409 3909-8004 61.9 µM 0.543742225010268 0.303487259350337 no 1018 0.293309435603708 314 2119279
SGTC_523 1934-0222 13.7 µM 0.542548194119025 0.303882015269611 no 1019 0.29372045821622 369 1361595
SGTC_1239 0337-0584 35.4 µM 0.53973971962397 0.304811420342156 no 1020 0.294688271881256 339 914301 YML130C ERO1
SGTC_3274 9138298 49.47 µM 0.539726449749152 0.304815814723328 no 1021 0.294692848232368 323 17015756
SGTC_3138 9097216 49.47 µM 0.53969884217553 0.304824957190809 no 1022 0.294702369297616 325 25237486
SGTC_3087 9117406 49.47 µM 0.538846019026754 0.305107436361939 no 1023 0.294996553545809 295 42546093
SGTC_1192 1488-0095 21.4 µM 0.537947737650982 0.30540509819033 no 1024 0.295306564985457 329 915875
SGTC_638 3970-0837 4.09 µM 0.537613648443647 0.305515837554738 no 1025 0.295421902815187 311 4118451 YLR208W SEC13
SGTC_2982 9019404 25.97 µM 0.537039388141686 0.305706227158599 no 1026 0.295620203471388 288 22333232
SGTC_1122 capsaicin 818.572 nM 0.536516899612934 0.305879498054443 no 1027 0.295800679705094 352 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1904 st060225 78 µM 0.534762926676575 0.306461479109893 no 1028 0.296406900980439 302 66595
SGTC_1301 naphtanilide LB 4.81 µM 0.534293977546354 0.30661716268602 no 1029 0.296569079130931 322 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3333 9141820 12.094 µM 0.533752126423012 0.306797092012494 no 1030 0.296756519812718 337 1939433
SGTC_7 0192-1582 4.227 µM 0.533715830944343 0.30680914610362 no 1031 0.296769077319863 339 252616
SGTC_2803 7707263 71.43 µM 0.533562353862831 0.306860119685123 no 1032 0.296822179998675 327 2199229
SGTC_272 doxorubicin 8.13 µM 0.533151496839752 0.306996593967159 no 1033 0.296964356881356 334 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2572 astragaloside iv 100 µM 0.532585491317377 0.307184647691788 no 1034 0.297160273837489 314 45006101 An anti-inflammatory agent.
SGTC_2109 5483026 200 µM 0.532259504218091 0.307292978999642 no 1035 0.29727313770875 352 759335
SGTC_3072 9116419 49.47 µM 0.53200535231841 0.30737744986087 no 1036 0.297361144248123 315 17170162
SGTC_1966 st070145 16.1 µM 0.531001985743172 0.307711032238552 no 1037 0.297708701554412 340 3748532
SGTC_894 0960-0238 55.9 µM 0.530754523357947 0.307793328812006 no 1038 0.29779444881988 329 6741907 YDL195W SEC31
SGTC_637 1181-0519 7.26 µM 0.529503220875859 0.308209612417964 no 1039 0.298228205348552 325 6252091 YGR060W ERG25
SGTC_1853 st056710 91.2 µM 0.529436598140963 0.308231783409783 no 1040 0.298251307786671 358 269167
SGTC_2502 avocadyne acetate 18.59 µM 0.527953391106463 0.308725552286077 no 1041 0.298765843074553 295 3952079
SGTC_1478 0453-0656 35.7 µM 0.527545135141717 0.308861524006689 no 1042 0.298907540809495 337 5258496
SGTC_2100 5377183 190 µM 0.527514637641359 0.308871682405883 no 1043 0.298918127126313 326 2844202
SGTC_3323 9138564 53.9225 µM 0.527510924312243 0.308872919287056 no 1044 0.29891941611173 323 43912313 YNL103W MET4
SGTC_840 0245-0196 390 µM 0.526949534148756 0.309059938931327 no 1045 0.299114317112713 315 3827528
SGTC_1491 4138-0063 26.5 µM 0.526636720285537 0.309164170176096 no 1046 0.299222943493157 343 23883227
SGTC_543 3844-1095 191 µM 0.526257351737987 0.309290598408946 no 1047 0.299354705375928 332 4230703
SGTC_2755 lomerizine 42.69 µM 0.526154485863813 0.309324883347557 no 1048 0.299390437177019 323 3949 A calcium channel blocker.
SGTC_3131 9127911 49.47 µM 0.525779591214868 0.309449848845162 no 1049 0.299520678081909 303 45595681
SGTC_369 0957-0393 4.5 µM 0.52570603522798 0.309474370214679 no 1050 0.299546234936355 326 6997992
SGTC_781 4335-2806 94.4 µM 0.525542062389886 0.309529036915634 no 1051 0.299603210469828 350 845254
SGTC_1329 1447-1697 50.6 µM 0.525054058096406 0.309691756994614 no 1052 0.299772806045723 326 2840515
SGTC_1290 0986-0249 10.2 µM 0.524101962533107 0.310009330962948 no 1053 0.300103811815421 334 53329
SGTC_3030 9087619 49.47 µM 0.522076237700009 0.310685488358664 no 1054 0.300808625222543 319 25236973
SGTC_2540 epiandrosterone 100 µM 0.521771208437322 0.310787358167425 no 1055 0.300914819157003 347 441302 A steroid.
SGTC_2513 baicalein 25.65 µM 0.520614138491766 0.311173913551697 no 1056 0.301317799064886 328 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_625 k213-0058 121 µM 0.519052546009892 0.311695942658694 no 1057 0.301862049468691 335 3655420
SGTC_3001 9076041 71.4286 µM 0.518345813489452 0.31193232276913 no 1058 0.302108506902438 325 16004211
SGTC_2301 7769476 200 µM 0.518005187205719 0.312046279374157 no 1059 0.302227325088061 329 977820
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.517564738896744 0.312193658131198 no 1060 0.302380994546078 321 6708514
SGTC_1311 1190-0148 100 µM 0.514522026967165 0.313212602441002 no 1061 0.303443532132962 354 1961333
SGTC_1591 genipin 88.4 µM 0.514040754619096 0.313373902049442 no 1062 0.303611748677889 336 442424 A DNA cross-linking agent.
SGTC_1664 st014217 9.02 µM 0.513813047851626 0.313450230975671 no 1063 0.303691352310603 352 3982782
SGTC_2895 9054447 58.44 µM 0.513247332438066 0.313639897378787 no 1064 0.30388916013544 343 2697450
SGTC_2342 7990637 118.86 µM 0.512724615440564 0.313815191579149 no 1065 0.304071984211512 357 2033102 YER133W GLC7
SGTC_34 0469-0683 81.75 µM 0.511533183435147 0.314214897754971 no 1066 0.304488879317965 333 3690923
SGTC_1238 0333-0287 48.8 µM 0.511323984566324 0.314285103103588 no 1067 0.304562106536679 329 7226
SGTC_1433 4060-0023 7.6 µM 0.511265238355446 0.314304819037196 no 1068 0.304582671257622 317 3840627
SGTC_2152 5568786 200 µM 0.511226907848279 0.314317683501162 no 1069 0.304596089582541 354 5399883
SGTC_23 0213-0011 39.996 µM 0.509831603553863 0.314786128195442 no 1070 0.305084721337783 327 627608
SGTC_1718 roemerine 11.9335 µM 0.509067060293027 0.315042934370998 no 1071 0.305352609810878 306 235224 An aporphine alkaloid with mutagenic activity.
SGTC_972 1319-0219 195 µM 0.508146717923385 0.315352191292329 no 1072 0.305675227081037 346 23903702
SGTC_590 k048-0076 22.4 µM 0.507581912034269 0.315542043596039 no 1073 0.30587328915546 345 6832814
SGTC_3255 9139072 49.47 µM 0.507499009724289 0.315569914251027 no 1074 0.305902365523031 332 17646060
SGTC_231 b-estradiol 524 µM 0.505062037851218 0.316389659933009 no 1075 0.306757631761362 311 450 A steroid.
SGTC_614 0462-0418 107 µM 0.504378736084732 0.316619670429797 no 1076 0.306997628828928 328 5188303
SGTC_1856 st057054 55.7 µM 0.50337315929713 0.316958292925086 no 1077 0.307350969450003 359 1266018
SGTC_1767 st044992 70.3 µM 0.502691799267658 0.317187824385242 no 1078 0.307590488141785 334 9600693
SGTC_2683 piperine 63.03 µM 0.501082207555593 0.317730330821197 no 1079 0.308156634107419 352 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2137 5261020 140 µM 0.49986087058425 0.318142238907868 no 1080 0.308586523072819 332 763655
SGTC_2587 piperic acid 92.2 µM 0.4984902308739 0.31860476879916 no 1081 0.309069276559827 325 5370536
SGTC_2553 4-methylesculetin 85.09 µM 0.497006785019906 0.319105684415302 no 1082 0.309592133322117 335 5319502
SGTC_1213 1315-0166 115 µM 0.496721386578735 0.319202092929175 no 1083 0.309692769392657 325 768401
SGTC_47 0149-0135 24.25 µM 0.494284937657558 0.320025630468788 no 1084 0.310552480564714 320 5239155
SGTC_3116 9124943 49.47 µM 0.493274930059741 0.320367280905825 no 1085 0.310909169922067 300 41905195 YPL160W CDC60
SGTC_900 1112-0045 141 µM 0.492599865557041 0.320595716684701 no 1086 0.31114767153168 332 56211 YIL048W NEO1
SGTC_2489 cantharidin 73.42 µM 0.49196010682967 0.320812268038762 no 1087 0.311373772752392 346 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1331 1472-0049 76.2 µM 0.491764252558252 0.320878574769916 no 1088 0.311443005095072 339 24051409
SGTC_244 nsc-207895 1.295 µM 0.49110722948077 0.32110105255472 no 1089 0.311675304261816 331 42640
SGTC_2838 9002687 71.43 µM 0.489104634483988 0.321779556983166 no 1090 0.312383810273698 353 6457060
SGTC_1622 st003707 19.4 µM 0.487421293343474 0.322350354410948 no 1091 0.312979903388308 337 10140899
SGTC_13 0199-0087 65 µM 0.486866858438886 0.322538447349014 no 1092 0.313176343220474 344 4589825
SGTC_3094 9117742 49.47 µM 0.485572499288252 0.322977737544538 no 1093 0.313635149289269 344 17149698
SGTC_789 1309-1135 70.6 µM 0.484285795396464 0.323414674532219 no 1094 0.314091527730304 337 3092424
SGTC_456 gingerol 170 µM 0.484115529974973 0.323472511275621 no 1095 0.314151940158425 362 442793 A herb.
SGTC_1812 st052057 4.327 µM 0.483991099612231 0.323514781198745 no 1096 0.314196092849781 328 3645418
SGTC_2900 5328528 85.29 µM 0.482901831622963 0.32388491085214 no 1097 0.314582720608548 331 795359
SGTC_1628 st004252 77.7 µM 0.481393753798904 0.324397638218347 no 1098 0.315118337580878 337 692968
SGTC_2400 5203494 178.7 µM 0.480084445931338 0.324843056507707 no 1099 0.315583673849242 348 6777674
SGTC_1146 3579-1023 7 µM 0.478558259790965 0.325362571634924 no 1100 0.316126459285085 354 X1146
SGTC_3055 9094636 49.47 µM 0.477562674904463 0.325701652688728 no 1101 0.316480751103659 331 25236176
SGTC_2813 7971799 71.43 µM 0.476563835081306 0.32604198729989 no 1102 0.316836370550187 348 2234054
SGTC_2940 9060638 45.86 µM 0.475626097830968 0.326361634380185 no 1103 0.317170389598682 339 4027022
SGTC_3020 9089140 49.47 µM 0.474777782727912 0.326650909990624 no 1104 0.317472685139892 337 17217859
SGTC_2723 salbutamol 83.58 µM 0.474109122065969 0.326878996885622 no 1105 0.317711046980369 355 9884233 β2-adrenoceptor agonist
SGTC_2665 lovastatin 100 µM 0.473940167527563 0.326936639225021 no 1106 0.31777128727408 342 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2947 9072639 7.68 µM 0.472026252353542 0.327589899093514 no 1107 0.318454025177122 335 16488146
SGTC_2952 9073731 13.78 µM 0.471264338716687 0.327850103479683 no 1108 0.318725989262191 323 16457353
SGTC_646 4092-0839 27.3 µM 0.471106920459686 0.327903874486701 no 1109 0.318782191683378 373 877796
SGTC_1899 st063254 59.6 µM 0.470892633559246 0.327977076447225 no 1110 0.318858704391306 340 3093813
SGTC_2247 cerulenin 830 nM 0.470644631895327 0.328061803865865 no 1111 0.318947264841114 327 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2068 5226020 147 µM 0.46986785024534 0.328327241199532 no 1112 0.319224717487566 349 1810509
SGTC_1262 0737-0114 49.6 µM 0.469712103296904 0.328380472583289 no 1113 0.319280359732829 354 765919
SGTC_3290 9121031 71.43 µM 0.469636092888962 0.328406452779278 no 1114 0.319307516733504 337 17014854
SGTC_68 0986-0284 82.829 µM 0.468362700987909 0.328841818731802 no 1115 0.319762618294214 318 423278 YIL048W NEO1
SGTC_930 2810-3379 265 µM 0.468234219576707 0.328885758760424 no 1116 0.319808551761047 360 1015764
SGTC_2718 lomofungin 53.02 µM 0.46802989464262 0.328955641782517 no 1117 0.319881605783042 350 5351222 A RNA synthesis inhibitor.
SGTC_2760 etidronate 98.04 µM 0.467740584479086 0.329054601599527 no 1118 0.319985057242113 344 3305 A chelator and antioxidant.
SGTC_3067 9117431 49.47 µM 0.467248865264572 0.329222823810039 no 1119 0.320160918196587 366 17150885
SGTC_632 0781-2353 4.65 µM 0.466309806455581 0.329544181567526 no 1120 0.320496880200675 358 6811515 YHR007C ERG11
SGTC_2546 rhodinyl acetate 100 µM 0.46455654970024 0.3301445049917 no 1121 0.321124527061816 335 6708682
SGTC_209 4077-0173 175.592 µM 0.464022172828389 0.330327565245349 no 1122 0.321315929935808 321 15993494
SGTC_1722 st034304 3.6505 µM 0.463813837683112 0.330398945142224 no 1123 0.32139056418945 355 4036148 YLR033W RSC58
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.460053341033126 0.331688427309744 no 1124 0.322738966906314 390 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1121 fusaric acid 630.51 nM 0.458051087214981 0.332375820073904 no 1125 0.323457869304171 323 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_59 0330-0160 1.33 µM 0.457774004282799 0.332470989769651 no 1126 0.323557406994531 350 4293482
SGTC_1386 3228-0095 33.8 µM 0.457756714489682 0.332476928654269 no 1127 0.323563618499662 370 870181
SGTC_3316 9136639 10.545 µM 0.457230360849164 0.332657746400926 no 1128 0.323752739040953 350 4903665
SGTC_1754 st042065 16.137 µM 0.456845639031483 0.332789934140722 no 1129 0.323890999614229 349 1126236 YIL048W NEO1
SGTC_2206 7254556 146.969 µM 0.455985361977355 0.333085594543677 no 1130 0.324200252202628 336 4398905
SGTC_1374 2889-5571 141 µM 0.455184068585355 0.333361076773029 no 1131 0.324488410476531 340 2853281
SGTC_889 0919-1524 82.7 µM 0.453904925947116 0.333801028393147 no 1132 0.324948628978655 342 3905452
SGTC_814 3342-0569 96 µM 0.452777733132707 0.334188907495362 no 1133 0.325354399519719 371 4346283
SGTC_3296 9122258 64.045 µM 0.452635823023893 0.334237752844485 no 1134 0.325405499472507 358 4730474
SGTC_387 norethindrone acetate 66.7 µM 0.450988185052814 0.33480507387141 no 1135 0.32599903219177 369 541197
SGTC_1212 0520-0165 585 µM 0.448401751389475 0.335696405194795 no 1136 0.326931639018126 387 5403258
SGTC_210 3551-0445 56.827 µM 0.448016733413345 0.335829168512552 no 1137 0.327070560059466 355 2865180 YOR207C RET1
SGTC_1440 4100-1550 40 µM 0.446056579483766 0.336505393424477 no 1138 0.327778188204778 371 742806
SGTC_1931 st074438 57.1 µM 0.44541024847398 0.336728484436147 no 1139 0.328011653651476 382 2787313
SGTC_1646 st011709 75.6 µM 0.445386877110006 0.336736552496112 no 1140 0.328020097034311 350 5757843
SGTC_1662 st014054 52 µM 0.443654327541723 0.337334857289509 no 1141 0.328646260475377 362 2838777
SGTC_2117 5521686 200 µM 0.443559866925137 0.337367489406735 no 1142 0.328680413489044 354 803312
SGTC_1376 2910-0861 41.3 µM 0.443492261822497 0.337390844839516 no 1143 0.328704857549122 364 1112859
SGTC_1236 0330-0013 258 µM 0.441478400211553 0.338086857532957 no 1144 0.329433347662397 368 4617066
SGTC_2630 antimycin a 100 µM 0.441402555131572 0.338113081261378 no 1145 0.329460796380225 357 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2431 5490079 200 µM 0.441371712789009 0.338123745344731 no 1146 0.329471958642734 378 5722345
SGTC_1073 triclabendazole 3.09 µM 0.440809692447551 0.33831809287582 no 1147 0.329675388038724 349 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_587 k089-0003 57 µM 0.440637218946417 0.338377743129355 no 1148 0.329737826814662 364 9659696
SGTC_2218 6965428 192.983 µM 0.440124781701178 0.338554994344809 no 1149 0.329923367094499 357 675684
SGTC_824 1304-0008 100 µM 0.440124683696408 0.338555028247923 no 1150 0.329923402583497 368 768245
SGTC_1467 k284-1082 293 µM 0.439082438888161 0.338915649385621 no 1151 0.330300901583688 368 3334705
SGTC_484 loperamide 105 µM 0.437290411223664 0.339536043684607 no 1152 0.330950374228761 347 3955 An opioid-receptor agonist.
SGTC_1629 st005085 44.9 µM 0.436950608157282 0.339653731551338 no 1153 0.3310735842669 361 24207091
SGTC_252 miconazole 1.30953 nM 0.434953741650022 0.340345644654629 no 1154 0.331798002334645 351 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2679 rapamycin 1 nM 0.434842624632583 0.340384162455076 no 1155 0.33183833158854 340 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3143 9086658 49.47 µM 0.434422858967131 0.340529685795869 no 1156 0.331990700597133 367 25236626
SGTC_2526 patulin 37.61 µM 0.432175457943914 0.341309212735205 no 1157 0.332806947545727 334 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_455 paf C-16 10 µM 0.43187091244629 0.341414898700703 no 1158 0.332917618335977 360 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2085 5307070 144.047 µM 0.430179665770496 0.342002035605529 no 1159 0.333532476235722 389 2840351
SGTC_2029 5175081 200 µM 0.42929528295806 0.342309212192315 no 1160 0.333854174586108 345 1380876
SGTC_3309 9129340 25.759 µM 0.428421466304035 0.342612821288877 no 1161 0.334172149427246 342 17158987
SGTC_2059 5238311 157 µM 0.427189052005443 0.343041198597344 no 1162 0.334620817391712 351 703021
SGTC_2267 7931562 200 µM 0.426311565370778 0.343346328943083 no 1163 0.334940415805782 347 934880
SGTC_2581 avocatin a 64 µM 0.42624217717358 0.343370461812816 no 1164 0.334965693497715 372 6710728 A skin care supplement.
SGTC_1651 st011928 86.1 µM 0.425202341616345 0.34373218789102 no 1165 0.335344588667681 362 720198
SGTC_3189 9110682 49.47 µM 0.425021940033401 0.343794958504013 no 1166 0.335410340443659 365 17122418
SGTC_1308 1187-1617 41.4 µM 0.423311076683712 0.344390466149965 no 1167 0.33603415688359 370 2882570
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.422830311140282 0.344557877835249 no 1168 0.336209535431465 383 688667
SGTC_1051 3253-3903 78 µM 0.422476770390504 0.344681006865201 no 1169 0.336338526376534 369 5509239
SGTC_1057 3448-5381 134 µM 0.420647647245342 0.345318305342975 no 1170 0.337006197671863 360 5497911
SGTC_680 0417-1641 114 µM 0.419838738040875 0.345600283506416 no 1171 0.337301631816972 357 2835990
SGTC_2877 9040724 71.43 µM 0.419271762376491 0.34579797699708 no 1172 0.337508765528599 360 6463895
SGTC_690 glyoxal 20.3 µM 0.418946731667822 0.345911327909831 no 1173 0.337627531490367 364 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2285 7945142 200 µM 0.416387773800389 0.346804218214451 no 1174 0.338563136740401 378 2970608
SGTC_1596 piperlongumine 63 µM 0.415980279290749 0.346946482901995 no 1175 0.3387122169303 341 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_866 0495-0101 262 µM 0.415540133249013 0.347100171149354 no 1176 0.338873270939635 372 635694
SGTC_1637 st007924 17.4 µM 0.415357892700175 0.347163812462229 no 1177 0.338939963275102 359 683336
SGTC_2797 7859098 81.82 µM 0.41469780732491 0.347394360896085 no 1178 0.339181568858707 353 972681
SGTC_1065 prochlorperazine maleate 2.48 µM 0.413417997730229 0.347841521621513 no 1179 0.339650195336548 383 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_777 1315-0167 517 µM 0.413212686709987 0.347913276253186 no 1180 0.339725396949577 358 4221767
SGTC_1297 1068-0111 14.1 µM 0.412934526929738 0.348010499657747 no 1181 0.339827291887235 362 767057
SGTC_1300 1094-0077 113 µM 0.412405863667445 0.348195307475954 no 1182 0.340020983019006 370 5532636
SGTC_163 TUB2.036 7.546 µM 0.410785166891398 0.348762088171779 no 1183 0.340615035333023 364 15992207 YJR013W GPI14
SGTC_772 k072-0172 35.3 µM 0.408513183729082 0.349557201278109 no 1184 0.341448476765922 335 5861980
SGTC_3038 9091290 49.47 µM 0.407082552523839 0.350058210325416 no 1185 0.34197367872533 410 25236843
SGTC_2789 5281112 71.43 µM 0.406173615922946 0.350376656902067 no 1186 0.342307519308914 352 765948
SGTC_3173 9105693 49.47 µM 0.405079576697915 0.350760093823582 no 1187 0.342709509140743 375 17096658
SGTC_474 dl-dihydrosphingosine 5 µM 0.40353391254484 0.351302074559178 no 1188 0.343277746024787 341 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1024 4507-0395 26 µM 0.402499916611092 0.351664809909654 no 1189 0.343658074860357 351 4201836
SGTC_3259 9138485 49.47 µM 0.402280549110932 0.351741783442006 no 1190 0.343738783927223 348 17646153
SGTC_1380 2291-0730 164 µM 0.401872811489639 0.351884870028378 no 1191 0.343888816513903 345 2999191
SGTC_530 4358-1714 28 µM 0.401497003544803 0.352016770174387 no 1192 0.344027121917197 385 1564641
SGTC_1202 1988-0068 29.6 µM 0.401457435519222 0.352030658698915 no 1193 0.344041685015929 359 2850480
SGTC_3130 9127414 49.47 µM 0.401387080210631 0.352055354162118 no 1194 0.344067580013149 357 1494646
SGTC_2097 5376186 200 µM 0.400228528358307 0.352462107883131 no 1195 0.344494102066311 362 742755
SGTC_1480 1070-0044 41.2 µM 0.399873883554891 0.352586653200405 no 1196 0.344624704482001 369 3124987
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.397868008060663 0.353291380226256 no 1197 0.345363741646563 378 676296 Flavone; oxidizing agent.
SGTC_2875 9039966 71.43 µM 0.396862928704009 0.353644685606454 no 1198 0.345734271327804 401 6463691
SGTC_612 0302-0167 22.4 µM 0.396791750406589 0.353669710978573 no 1199 0.345760517324179 391 235821
SGTC_1501 4491-0275 38.4 µM 0.396283247856154 0.353848512313975 no 1200 0.345948042047548 400 5104718
SGTC_276 colchicine 750 µM 0.394992868267972 0.354302384453222 no 1201 0.346424075619122 399 2833 A microtubule depolymerizer.
SGTC_2044 5102272 200 µM 0.394793063510018 0.354372681378701 no 1202 0.346497807251939 358 592666
SGTC_923 1900-2434 73.3 µM 0.393293980722993 0.354900258919674 no 1203 0.347051181738812 387 5910570
SGTC_1801 st050089 28.441 µM 0.393123255091748 0.354960360673531 no 1204 0.347114224467488 360 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2191 5911152 200 µM 0.392667307832375 0.355120888706111 no 1205 0.347282609842603 373 2875902
SGTC_578 3460-0051 92 µM 0.391087781803158 0.355677200426857 no 1206 0.347866175794388 419 2876744
SGTC_2722 naftopidil 47.16 µM 0.390756495164272 0.355793919193119 no 1207 0.347988617541473 398 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2714 st079313 56.9 µM 0.390071986591047 0.356035127776609 no 1208 0.348241658402054 364 2939799
SGTC_91 0417-1751 58.384 µM 0.389662837617357 0.356179332085865 no 1209 0.348392939924784 370 6795624
SGTC_2750 bromebric acid 70.15 µM 0.388568382273854 0.356565173278464 no 1210 0.348797729781768 371 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3211 9128781 49.47 µM 0.386762409579342 0.357202174946693 no 1211 0.349466054216432 391 17194361
SGTC_222 nsc-310342 10.666 µM 0.385165320011443 0.357765831337042 no 1212 0.350057467788156 412 432556
SGTC_3031 9088762 49.47 µM 0.38458968648659 0.357969064220403 no 1213 0.350270718244308 379 205253
SGTC_307 1501-1223 22.3 µM 0.381718205192762 0.358983468281482 no 1214 0.351335197510276 395 2830329
SGTC_1442 4112-3290 3 µM 0.381324362105563 0.359122678431056 no 1215 0.351481289251726 385 704353
SGTC_744 1594-0068 283 µM 0.380330871815322 0.359473926573276 no 1216 0.351849910940102 374 668392
SGTC_1868 st057644 42.7 µM 0.379490310237777 0.359771199591505 no 1217 0.352161899221092 354 688665
SGTC_433 pimozide 108 µM 0.378963437891038 0.359957576548513 no 1218 0.35235750733498 366 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_363 0455-0021 3.06 µM 0.378802532300607 0.360014502277808 no 1219 0.352417253386532 395 4597466
SGTC_1281 0884-0031 11.8 µM 0.378274235646232 0.36020142669712 no 1220 0.352613441463226 372 1548255
SGTC_1950 st077106 7.18 µM 0.377338745522123 0.360532508213002 no 1221 0.352960940937535 354 13831864
SGTC_662 k832-1615 104 µM 0.376803983672371 0.360721814037012 no 1222 0.353159640024939 417 5878478
SGTC_3026 9090633 49.47 µM 0.37420262790686 0.361643180725184 no 1223 0.354126784504744 369 25236842
SGTC_2122 5258151 111.688 µM 0.373783146294052 0.361791831006286 no 1224 0.354282829721215 368 2173356
SGTC_350 k064-0020 19.8 µM 0.372880859499333 0.362111641980043 no 1225 0.354618559118134 374 2790705
SGTC_1800 st050079 29.0735 µM 0.370854474605445 0.362830234475673 no 1226 0.355372962476088 384 3645560
SGTC_1670 st016595 4.04 µM 0.369220616055619 0.363409982170334 no 1227 0.355981645218275 418 597879
SGTC_860 0443-0016 25.1 µM 0.36880045669632 0.363559119419746 no 1228 0.356138232120034 373 5337942
SGTC_2053 5265679 138 µM 0.366031551178149 0.364542469769515 no 1229 0.357170766200289 379 764595
SGTC_2357 9067248 200 µM 0.36424342631738 0.365177979728393 no 1230 0.357838120737289 401 9150235
SGTC_1548 st061468 90.8 µM 0.363333988611691 0.365501341399209 no 1231 0.358177703205317 399 390799
SGTC_2654 protoveratrine a 100 µM 0.361741386429395 0.366067840753362 no 1232 0.358772648308459 413 5702278 A heart drug and vasodilator.
SGTC_2777 climbazole 1.536 µM 0.361405566527902 0.366187331490097 no 1233 0.358898143667993 389 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.361297814649622 0.366225674289127 no 1234 0.358938413600743 365 5282362
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.360047718681898 0.366670610286555 no 1235 0.359405724414035 379 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1198 1612-1005 86.7 µM 0.358957836016377 0.367058669196921 no 1236 0.359813315985772 384 6998509
SGTC_2418 pentamidine 31.67 µM 0.358309117229772 0.367289713731827 no 1237 0.360055997947448 391 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_88 0180-0332 8.668 µM 0.35747382777189 0.367587277141305 no 1238 0.360368557997014 363 3101745
SGTC_785 1270-0111 65.3 µM 0.356804831078336 0.367825657790945 no 1239 0.360618959669375 373 6741994
SGTC_1007 4101-0031 70 µM 0.356430827289475 0.36795894711299 no 1240 0.3607589732261 405 1146276
SGTC_107 0358-0022 2.6945 µM 0.356283591877186 0.368011423960872 no 1241 0.360814097986406 404 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_330 1488-0319 80.1 µM 0.352330450739211 0.369421299129952 no 1242 0.362295227012495 384 6846614
SGTC_1696 st025591 34.7925 µM 0.352283102528516 0.369438196408752 no 1243 0.362312979585515 379 2787147
SGTC_1529 apigenin 74 µM 0.351691255067065 0.369649431817361 no 1244 0.362534909782006 413 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1563 conessine 56.1 µM 0.350204638268703 0.370180191447287 no 1245 0.363092563039838 406 441082 An anti-amoebic, histamine inhibitor.
SGTC_927 2425-1185 123 µM 0.350188731562428 0.370185871880919 no 1246 0.363098531466825 412 730375
SGTC_82 0054-0107 293.755 µM 0.349466890307229 0.370443677924843 no 1247 0.363369411745094 376 3104697
SGTC_1554 st069299 38.7 µM 0.349186820796236 0.37054372059849 no 1248 0.363474529864419 363 24207999
SGTC_3348 9149464 3.537 µM 0.34646236788174 0.371517369002704 no 1249 0.364497630508415 366 1951442
SGTC_225 nsc-122657 1.016 µM 0.34504035632513 0.372025885981412 no 1250 0.365032015815574 398 275685
SGTC_2582 agaric acid 100 µM 0.343141068586243 0.372705426991426 no 1251 0.365746168187542 385 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1721 st082152 9.2685 µM 0.342966671312148 0.372767844019849 no 1252 0.365811766788443 387 5296051
SGTC_445 e6 berbamine 66 µM 0.342574457624031 0.372908230050512 no 1253 0.365959310199572 400 6610268 A calcium/calmodulin antagonist.
SGTC_572 0960-0087 17.7 µM 0.340503207370766 0.373649877391659 no 1254 0.366738803904637 410 6796365
SGTC_420 mitomycin C 81.9 mM 0.339276617034665 0.374089300386855 no 1255 0.367200678007673 385 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3203 9113543 49.47 µM 0.337683955143983 0.374660111768594 no 1256 0.367800683591563 386 17018012
SGTC_2907 7721985 69.9 µM 0.333824083593903 0.376044630643715 no 1257 0.369256154418946 375 3267881
SGTC_783 0848-0141 92.7 µM 0.332828965659215 0.376401834702413 no 1258 0.369631696075608 418 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_332 4112-0506 40.9 µM 0.332045847744627 0.376683014438007 no 1259 0.369927319789088 420 2790355
SGTC_1288 0973-0013 65.5 µM 0.331656570328947 0.376822809471001 no 1260 0.370074298990387 395 4315430
SGTC_2696 st077691 74.316 µM 0.33159607376793 0.376844536093332 no 1261 0.370097142338836 433 757133
SGTC_1174 0739-0097 51.1 µM 0.331460443546916 0.376893247495769 no 1262 0.370148357632534 406 728447
SGTC_1922 5578187 25 µM 0.331032563257854 0.377046932936994 no 1263 0.370309944486733 404 1350412
SGTC_481 bay k-8644 50 µM 0.329764814436336 0.37750239545565 no 1264 0.370788837771685 398 2303 A calcium channel antagonist.
SGTC_2649 anisomycin 9.56 µM 0.329155312511179 0.377721431142146 no 1265 0.371019149007596 394 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1574 spiramycin 23.7 µM 0.32707031969245 0.378471008480038 no 1266 0.371807349890639 389 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1763 st044482 94.5 µM 0.325775188852128 0.378936852496357 no 1267 0.372297225990217 412 88505
SGTC_2133 5320837 200 µM 0.325760219838809 0.378942237711902 no 1268 0.372302889146896 403 2841355
SGTC_1036 k216-0215 33.5 µM 0.325602261164913 0.378999065969423 no 1269 0.37236265059496 390 622330
SGTC_1565 sinapyl alcohol 95.1 µM 0.32544782148785 0.379054630738147 no 1270 0.372421083651715 420 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1078 idebenone 36.1 µM 0.325429384303558 0.379061264290441 no 1271 0.372428059652753 404 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1953 st076800 12.1 µM 0.324611874128277 0.379355433725981 no 1272 0.372737419634007 388 297591
SGTC_305 1682-2595 20.8 µM 0.324403363390625 0.379430474544618 no 1273 0.372816336850244 409 226033
SGTC_1087 pterostilbene 9.05 µM 0.324244085784032 0.379487799938177 no 1274 0.372876623890525 402 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2713 st079149 53.4 µM 0.323683381748415 0.379689623260342 no 1275 0.373088876772909 393 3103253
SGTC_2698 st077697 67.5 µM 0.322995880418754 0.37993713152759 no 1276 0.373349180974767 386 3154499
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.321934920641256 0.380319185557747 no 1277 0.373750998747989 421 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2620 irigenin 100 µM 0.321842628359776 0.380352425745106 no 1278 0.373785959140867 444 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2821 7996764 71.43 µM 0.321697696090935 0.380404626647074 no 1279 0.373840861700403 350 2987135
SGTC_2671 danthron 100 µM 0.321380090340027 0.380519027742441 no 1280 0.373961184565196 399 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1613 st002381 52.1 µM 0.321201727318985 0.380583278406747 no 1281 0.37402876161727 389 551167
SGTC_2988 9073640 71.4286 µM 0.319564970504399 0.38117303130538 no 1282 0.374649066207705 408 9102229
SGTC_1227 3909-8010 46.6 µM 0.319305548456686 0.381266531114076 no 1283 0.374747412838317 403 15982272
SGTC_76 0433-0009 400.328 µM 0.318552478258927 0.38153798876761 no 1284 0.37503294710216 436 2841569
SGTC_1712 st032288 53.4 µM 0.318202621396869 0.381664120780469 no 1285 0.375165622222453 410 2883011
SGTC_1713 st033146 12.748 µM 0.315080306701986 0.382790347140128 no 1286 0.376350340266882 407 674619
SGTC_1822 st052468 42 µM 0.313958447116942 0.383195247265172 no 1287 0.376776299281383 389 2873678
SGTC_317 4495-0002 170 µM 0.313077077189484 0.383513439722828 no 1288 0.377111052023736 402 15991618
SGTC_2507 purpurin 79.67 µM 0.311089803160673 0.384231174070107 no 1289 0.377866176364409 385 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_958 1222-0007 33 µM 0.310405411988904 0.384478444451461 no 1290 0.378126339545588 417 7312461
SGTC_2114 5491910 81.25 µM 0.310230386745776 0.384541688586318 no 1291 0.378192882194311 440 2849228
SGTC_479 n-linoleoylglycine 10 µM 0.309174805840707 0.384923180388571 no 1292 0.378594278844512 412 6433346 An anti-infammatory.
SGTC_411 enrofloxacin 100 µM 0.307347250746851 0.385583930491823 no 1293 0.379289537017394 431 71188 A bacterial gyrase inhibitor.
SGTC_1469 k284-2957 126 µM 0.307120473763793 0.385665944613422 no 1294 0.379375837243912 396 23884841
SGTC_2537 larixol 68.93 µM 0.305165681271375 0.386373108844758 no 1295 0.380119984436932 416 6708759
SGTC_3063 1327-0034 4 µM 0.303504795165329 0.386974246532877 no 1296 0.380752596849154 434 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2386 9075165 157.42 µM 0.303437305278478 0.386998679427201 no 1297 0.380778309725452 414 16452277
SGTC_1285 0929-0069 65.5 µM 0.303214176852403 0.387079460246234 no 1298 0.380863322855838 391 1206237
SGTC_1231 0242-0792 125 µM 0.302521818014002 0.387330151109644 no 1299 0.381127151893969 430 3707635
SGTC_2258 7960471 200 µM 0.302399227989509 0.387374543684508 no 1300 0.381173871594851 436 2974708
SGTC_125 0133-0007 11.75 µM 0.300375953386341 0.388107428755294 no 1301 0.381945201859246 442 26541
SGTC_3216 9129716 49.47 µM 0.299952183468701 0.388260980322604 no 1302 0.382106814584258 375 8056934
SGTC_1342 1486-1464 234 µM 0.299731396185369 0.388340988755518 no 1303 0.382191024159468 424 3253938
SGTC_497 capsazepine 133 µM 0.29971333351692 0.388347534477173 no 1304 0.382197913614667 382 2733484 A calcium channel blocker.
SGTC_1661 st013063 9.66 µM 0.298709610598605 0.388711322931448 no 1305 0.382580811739218 411 721395
SGTC_3145 9085516 49.47 µM 0.297730909359318 0.389066136555182 no 1306 0.382954275209276 393 25236195
SGTC_336 4111-0029 111 µM 0.296797573588314 0.389404589806724 no 1307 0.383310529023585 424 3131175
SGTC_195 4234-0266 16.654 µM 0.296158382990933 0.38963642634549 no 1308 0.383554564726943 412 2303354
SGTC_2451 5856223 45.7 µM 0.29582964286177 0.38975567677542 no 1309 0.38368009196766 404 2179896
SGTC_1363 1636-0063 10.4 µM 0.294763156863882 0.390142615801 no 1310 0.384087406563839 439 6072185
SGTC_2328 6201408 200 µM 0.294053388882135 0.390400191902587 no 1311 0.384358553659601 409 2890418
SGTC_2404 5161160 200 µM 0.293777049845032 0.390500488864566 no 1312 0.384464136608868 444 2831543
SGTC_1770 st043884 66.3 µM 0.293647241318962 0.390547605248024 no 1313 0.38451373649521 432 670149
SGTC_1406 3909-7906 11.9 µM 0.293423915204529 0.390628669314942 no 1314 0.384599073911072 431 X1406
SGTC_1975 st070967 30.8 µM 0.292849812500939 0.390837081891564 no 1315 0.384818475798438 455 261391
SGTC_743 1275-0778 158 µM 0.291865018449033 0.391194657941988 no 1316 0.385194915370655 428 2849257 YMR203W TOM40
SGTC_3224 9130643 49.47 µM 0.291406245303121 0.391361268653857 no 1317 0.385370319327784 389 17644395
SGTC_2885 9057732 51.95 µM 0.291071814049389 0.391482735208496 no 1318 0.385498198099003 410 6471414
SGTC_878 0828-0289 13.7 µM 0.28916445645137 0.392175695838307 no 1319 0.386227765070508 410 745350 YLR208W SEC13
SGTC_2283 7944793 200 µM 0.288910454787629 0.392268002847743 no 1320 0.386324951487237 447 2970533
SGTC_2816 7982706 58.44 µM 0.286628092692884 0.393097709824374 no 1321 0.387198550855979 397 2981853
SGTC_1694 st024011 44.9 µM 0.285912242734046 0.393358042992285 no 1322 0.387472668324854 426 2787533
SGTC_2887 9044784 58.44 µM 0.284212858617781 0.393976248825683 no 1323 0.388123630935737 452 6465546
SGTC_539 4859-0462 2.54 µM 0.281628334765915 0.394916964668018 no 1324 0.389114255633669 409 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2817 7995342 71.43 µM 0.280942941403626 0.395166537419214 no 1325 0.389377081989107 398 18879975
SGTC_725 1497-0963 19 µM 0.280663814482604 0.395268188425579 no 1326 0.389484132714124 437 3549977
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.278483117002628 0.396062588449376 no 1327 0.390320761672122 422 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1466 k213-0079 57.5 µM 0.276831988068272 0.396664360927107 no 1328 0.390954558878362 448 3657981
SGTC_256 clotrimazole 625 nM 0.275705400462782 0.397075099824972 no 1329 0.391387173687992 413 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1787 fluconazole 80 µM 0.274976028936897 0.397341079933638 no 1330 0.391667327402134 415 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2688 kanamycin b 96.69 µM 0.273969053735338 0.397708372287277 no 1331 0.392054201807381 424 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1070 indatraline 8.81 µM 0.273623448028176 0.397834452255284 no 1332 0.392187006267175 444 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2661 dactinomycin 12.96 µM 0.273350442281689 0.39793405467085 no 1333 0.392291921923441 422 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2850 9015429 58.44 µM 0.273105476509969 0.398023432747695 no 1334 0.39238606852883 432 6457570
SGTC_640 3381-0960 37.1 µM 0.272833153291378 0.398122798728913 no 1335 0.392490736693049 423 1745025
SGTC_799 1310-0557 151 µM 0.272529730378976 0.398233520226961 no 1336 0.392607367268157 436 5354492
SGTC_158 k038-0087 26.446 µM 0.272454648412698 0.398260919514534 no 1337 0.392636228980099 414 X158
SGTC_1884 5633444 25 µM 0.270994743131379 0.398793775015357 no 1338 0.393197537705149 420 5724239
SGTC_1272 0839-0021 27 µM 0.270540180581703 0.398959725824875 no 1339 0.393372354663948 441 5027250
SGTC_556 4058-0063 51.5 µM 0.270165633666289 0.399096478409808 no 1340 0.393516415140014 433 6615692
SGTC_2307 7538926 6.34 µM 0.269118144646799 0.399478997752632 no 1341 0.393919383972158 417 96582
SGTC_361 000s-0510 1.45 µM 0.268798442472968 0.399595765010165 no 1342 0.394042395987541 397 660
SGTC_3148 9097893 49.47 µM 0.267592500340459 0.400036301180044 no 1343 0.394506502184251 373 17174100
SGTC_708 3448-5400 146 µM 0.267554580006579 0.400050155717626 no 1344 0.394521098237245 436 3462195
SGTC_1298 1079-1278 263 µM 0.26691459611149 0.400283998597646 no 1345 0.394767459079727 428 2840950
SGTC_71 0417-1750 47.813 µM 0.265952866633606 0.400635470884312 no 1346 0.395137754517498 452 6811472
SGTC_1328 1441-0025 69.2 µM 0.265912611597379 0.400650184189008 no 1347 0.395153256012571 418 4562601
SGTC_1394 3474-0001 65.7 µM 0.265707757796669 0.400725060889278 no 1348 0.395232144120682 420 5017666 YIL048W NEO1
SGTC_1638 st008370 60.6 µM 0.265354721541288 0.400854108742092 no 1349 0.395368106578268 400 24207134
SGTC_413 propylparaben 100 µM 0.264652803419983 0.401110717993943 no 1350 0.395638469364969 404 7175 A pharmaceutical preservative.
SGTC_3312 9133330 71.43 µM 0.26076140749142 0.402534116792806 no 1351 0.397138253685632 438 17617324
SGTC_1898 st060199 18.6 µM 0.259481943252698 0.403002403939953 no 1352 0.397631706118039 409 688866
SGTC_258 haloperidol 50.781 µM 0.257489313615383 0.403731988331678 no 1353 0.398400531885487 435 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3029 9088683 49.47 µM 0.256873377603922 0.403957575978829 no 1354 0.398638261370682 400 25236615
SGTC_1441 4106-0040 13 µM 0.256810195038393 0.403980718512406 no 1355 0.398662649731828 410 2904180
SGTC_1635 st007035 42.4 µM 0.255229165797037 0.404559927715301 no 1356 0.399273052895929 408 3716403
SGTC_188 3229-0966 278.469 µM 0.255208008263603 0.404567680187572 no 1357 0.399281223062003 440 5722370
SGTC_688 0527-0193 473 µM 0.253983484792584 0.405016429699924 no 1358 0.399754158533524 434 4007154
SGTC_2695 st077686 51.995 µM 0.250820778375377 0.406176039230778 no 1359 0.400976338082942 403 2876092
SGTC_1465 k213-0056 144 µM 0.247779707084978 0.407291827952741 no 1360 0.402152428405463 433 24048857 YMR208W ERG12
SGTC_2614 arthonioic acid 13.39 µM 0.246708570858089 0.407685014476789 no 1361 0.402566886490666 415 6710684
SGTC_1013 4112-3890 241 µM 0.245505177943267 0.408126859950214 no 1362 0.40303264970835 409 705171
SGTC_2959 9079155 11 µM 0.245504933814927 0.408126949597817 no 1363 0.403032744210177 453 16189457
SGTC_2857 9024691 58.44 µM 0.2443033687213 0.40856824056829 no 1364 0.403497937324628 455 16478292
SGTC_3240 9133527 49.47 µM 0.243256580881688 0.408952782041849 no 1365 0.403903318841096 448 17617455
SGTC_1527 coumarin 137 µM 0.242991932848202 0.409050015393812 no 1366 0.404005823426125 467 323 A hepatotoxic, DNA x-linker.
SGTC_2056 5235370 200 µM 0.242933414927316 0.409071516001777 no 1367 0.404028489722579 413 5511916
SGTC_1737 st035557 69.7 µM 0.242802023235748 0.409119792829285 no 1368 0.404079384075642 435 5716916
SGTC_3281 9140613 49.47 µM 0.242055359979617 0.409394163067631 no 1369 0.404368633651049 389 16013766
SGTC_648 0375-0473 33.3 µM 0.241200596405968 0.409708310530221 no 1370 0.404699824339275 444 1713139
SGTC_2217 6934799 96.0675 µM 0.24084612847181 0.409838603574538 no 1371 0.404837188185796 435 675606
SGTC_2844 9010103 25.97 µM 0.240185586265922 0.410081427985351 no 1372 0.40509319358443 451 2480525
SGTC_278 4092-0821 23.9 µM 0.240091953205661 0.410115851580341 no 1373 0.405129486105217 438 877900
SGTC_1392 3455-1037 33.9 µM 0.239201217800698 0.410443359348534 no 1374 0.405474779201879 449 981132
SGTC_1789 tunicamycin 25 nM 0.23902957991774 0.410506474769027 no 1375 0.405541322997024 457 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_811 0416-0114 265 µM 0.238546964833412 0.410683956479314 no 1376 0.405728446893827 452 6612453
SGTC_1959 st077091 55.8 µM 0.2367897778096 0.411330316320821 no 1377 0.406409941097285 439 821356 YKL052C ASK1
SGTC_733 4069-0007 56.1 µM 0.236546789266761 0.411419715683606 no 1378 0.406504202313075 443 5717425 YNL287W SEC21
SGTC_1264 0783-0040 158 µM 0.236298763890992 0.411510972921068 no 1379 0.406600423027612 443 2855798
SGTC_3225 9130819 49.47 µM 0.236202866781845 0.411546258115577 no 1380 0.406637627540924 448 4547121
SGTC_585 0kpi-0023 191 µM 0.234808055912642 0.412059557374334 no 1381 0.407178857410686 445 64601
SGTC_1806 st050005 60.3 µM 0.234382950848471 0.412216028700645 no 1382 0.407343846654499 438 5194765
SGTC_924 2046-0044 21.3 µM 0.233960066323043 0.412371696544343 no 1383 0.407507990387427 411 3623589
SGTC_2356 9061756 188.97 µM 0.233648254046206 0.412486486461236 no 1384 0.407629031541034 431 20104043
SGTC_905 2-aminofluorene 215 µM 0.233570586339857 0.41251508005247 no 1385 0.407659182427881 420 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2913 7966556 36.57 µM 0.231114097382628 0.413419682380882 no 1386 0.408613081721182 459 2976516
SGTC_2366 9070441 60.58 µM 0.230290196243615 0.413723187268876 no 1387 0.408933139086239 422 6837235
SGTC_45 0kpi-0036 14.9 µM 0.230273480605715 0.413729345432326 no 1388 0.408939633168148 463 2795021
SGTC_380 3970-0968 6 µM 0.229698761821614 0.413941088938025 no 1389 0.409162928554142 457 2891601
SGTC_2352 9027995 87.8 µM 0.229271412481294 0.414098553378135 no 1390 0.409328985630532 440 2997347
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.229145289308473 0.414145028337448 no 1391 0.4093779969962 472 688669
SGTC_202 3594-0513 34.79 µM 0.227925026044776 0.414594743509801 no 1392 0.409852263379161 434 708429
SGTC_360 0957-0399 1.01 µM 0.227655536596976 0.414694076122115 no 1393 0.409957020704988 434 6752301 YPR165W RHO1
SGTC_2868 9035608 32.47 µM 0.227260098014465 0.414839842898859 no 1394 0.410110749259744 444 6462614
SGTC_557 1315-0110 16.2 µM 0.226663104793274 0.415059929060038 no 1395 0.410342859266652 447 6833801
SGTC_2664 lyso-paf C-16 73.48 µM 0.224713094302954 0.415779000890649 no 1396 0.411101238666923 442 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_812 4251-0442 148 µM 0.224097480400521 0.41600606893936 no 1397 0.411340726489547 462 5723007
SGTC_770 0389-1121 67.2 µM 0.22350468450761 0.41622474711066 no 1398 0.411571368815096 426 6753108
SGTC_2785 7756463 72.73 µM 0.221378629085549 0.417009246624113 no 1399 0.412398815577486 464 2201551
SGTC_971 1315-0384 26.7 µM 0.221158795566188 0.41709038255834 no 1400 0.41248439561703 456 6769120
SGTC_2882 9058044 58.44 µM 0.220099756667486 0.417481300990252 no 1401 0.412896732156821 429 18076804
SGTC_1709 st033179 39.1045 µM 0.219794008089445 0.41759417582732 no 1402 0.413015793193083 448 573381
SGTC_2468 5987765 72.9 µM 0.218775469615461 0.417970244057346 no 1403 0.413412478202025 423 26772094
SGTC_1741 st038134 10.228 µM 0.217671880061736 0.418377799803557 no 1404 0.413842387395749 450 1272587
SGTC_1897 st060201 15 µM 0.216670303737009 0.418747757933118 no 1405 0.414232646211053 434 611878
SGTC_2360 9040895 200 µM 0.214082150044578 0.419704091520676 no 1406 0.41524149765799 416 4914414
SGTC_1028 k015-0029 4.8 µM 0.213791087636222 0.419811670074987 no 1407 0.415354987658394 450 4588309
SGTC_2373 9071805 200 µM 0.212695096258373 0.420216809300363 no 1408 0.415782395936594 447 10149009
SGTC_1896 st058441 89 µM 0.212328319034089 0.420352409416347 no 1409 0.415925451841026 408 688759
SGTC_2624 nerol 100 µM 0.211713893582606 0.420579587996321 no 1410 0.416165124143251 445 637566 A natural product oil.
SGTC_2019 4016004 108 µM 0.211617236458365 0.420615328555296 no 1411 0.416202830557734 424 45595336
SGTC_1817 st052116 64.4 µM 0.211431245618847 0.420684103563453 no 1412 0.416275388658859 428 4361398
SGTC_3337 9144342 33.5465 µM 0.207040333602184 0.422308457642675 no 1413 0.417989179606126 438 17682949
SGTC_893 0958-0369 48.9 µM 0.205461933984655 0.422892688181185 no 1414 0.418605617954337 463 6819948
SGTC_156 3474-0145 5.642 µM 0.204488575154027 0.423253052909344 no 1415 0.418985859540428 460 2265471
SGTC_2556 citropten 84.59 µM 0.203811985261038 0.423503583306732 no 1416 0.419250213271933 390 2775 A potential DNA crosslinker.
SGTC_759 3486-0358 89.3 µM 0.203701645072062 0.4235444434468 no 1417 0.419293328284977 466 875103
SGTC_2254 7938975 95.19 µM 0.203697619755338 0.423545934079742 no 1418 0.419294901180643 444 2969277
SGTC_2238 6671620 73.2395 µM 0.20359658752591 0.423583348132374 no 1419 0.419334380025854 403 729941
SGTC_2836 9010338 19.48 µM 0.201651125957864 0.424303921531395 no 1420 0.420094736706524 452 2994051
SGTC_1493 4348-0038 111 µM 0.200415484102979 0.424761718617234 no 1421 0.420577825292906 475 800424
SGTC_977 1348-1378 135 µM 0.200411334119053 0.424763256330028 no 1422 0.420579447979489 476 X977
SGTC_990 3985-0011 41.3 µM 0.200217248555382 0.424835173032682 no 1423 0.420655338946781 465 5399565 YGL099W LSG1
SGTC_3193 9111931 49.47 µM 0.199788694909883 0.424993978683571 no 1424 0.420822921617996 449 17087244
SGTC_2277 7947813 106.88 µM 0.197832570247926 0.42571899815389 no 1425 0.421588031195029 463 1246798
SGTC_268 camptothecin 39.6153 µM 0.197541697924403 0.425826828797403 no 1426 0.421701827014132 458 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1337 1486-1011 40.3 µM 0.197234392534004 0.425940757445917 no 1427 0.421822058923156 447 X1337
SGTC_472 calcifediol 10 µM 0.197016442390597 0.426021562787205 no 1428 0.421907335394857 448 5283731 A vitamin D metabolite.
SGTC_213 1246-0773 967 nM 0.196762382573821 0.426115759764556 no 1429 0.422006744974356 463 6251622
SGTC_1082 camptothecin 424.86 nM 0.195780630532756 0.426479800524324 no 1430 0.422390935637706 501 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.195120012673448 0.426724797685268 no 1431 0.422649497914967 455 2333 A French combination drug.
SGTC_2330 7979373 200 µM 0.194864368403318 0.426819613675177 no 1432 0.422749564658163 429 1863007
SGTC_1771 st048882 4.1505 µM 0.193809925609035 0.427210740952837 no 1433 0.423162357431752 411 4580403
SGTC_1892 st058411 7.36 µM 0.193197517635068 0.427437935952203 no 1434 0.423402141377335 479 3934738
SGTC_1999 st074831 12.5 µM 0.192154206826306 0.427825045406445 no 1435 0.423810707527202 468 17112523
SGTC_1347 1493-0251 600 nM 0.192131038783243 0.427833642454056 no 1436 0.423819781189353 454 3986378
SGTC_1129 3453-1384 223 µM 0.190281833342919 0.428519943812235 no 1437 0.42454414423649 467 1084452
SGTC_1690 st023502 41.2 µM 0.18681312543466 0.429807877768936 no 1438 0.425903577739653 479 24207482
SGTC_2452 5863136 48.41 µM 0.186576703679589 0.429895688710446 no 1439 0.425996266876242 465 2184096
SGTC_2759 disulfiram 3.38 µM 0.186430030519102 0.429950167286166 no 1440 0.426053772136495 440 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3234 9132280 49.47 µM 0.18613308971985 0.430060463611088 no 1441 0.426170196735339 433 17612295
SGTC_2769 toremifene 3.73 µM 0.18464689768527 0.430612579807033 no 1442 0.426752999663825 454 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2240 6690706 185.951 µM 0.184581720745181 0.430636795971498 no 1443 0.426778562152015 417 805876
SGTC_1835 st008666 49.2 µM 0.184087712853021 0.430820350594966 no 1444 0.426972322738402 443 690455
SGTC_123 0083-0120 66.675 µM 0.183798187497078 0.430927934201123 no 1445 0.427085889041819 470 16001701
SGTC_1457 k015-0032 57.3 µM 0.183770468042634 0.430938234634877 no 1446 0.427096762313303 447 4302660
SGTC_2131 toluylene red 5.2905 µM 0.183494413888332 0.43104081777058 no 1447 0.427205050718323 429 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_133 0724-0033 378.92 µM 0.183098839250168 0.431187823437624 no 1448 0.427360233261476 495 280309
SGTC_1702 st027038 51 µM 0.182600930002744 0.431372872815538 no 1449 0.427555577288054 446 5521182
SGTC_3248 9135562 49.47 µM 0.182531409791012 0.431398711397936 no 1450 0.427582853467949 428 17650701
SGTC_1002 4049-0206 172 µM 0.181376634096304 0.431827949822712 no 1451 0.428035978991215 450 4662749
SGTC_1697 st025554 27.742 µM 0.180488532604303 0.432158118317696 no 1452 0.428384528110245 453 1269519
SGTC_1240 0356-0016 42.1 µM 0.177908180579856 0.433117680935956 no 1453 0.429397543083225 484 4305613
SGTC_2368 9071271 200 µM 0.177541493831229 0.433254073889115 no 1454 0.429541537761157 465 27209959
SGTC_1937 st074714 47.2 µM 0.177061620777611 0.433432579674464 no 1455 0.429729993869669 452 17250970
SGTC_1571 st070080 73.4 µM 0.176695428515201 0.433568806999154 no 1456 0.429873815946456 458 4315245
SGTC_130 0136-0219 337.655 µM 0.176658512660945 0.433582540518506 no 1457 0.42988831517152 484 234244
SGTC_3180 9109287 49.47 µM 0.175698977514705 0.43393953703099 no 1458 0.430265219316976 459 18891271
SGTC_2315 7733312 200 µM 0.175691832756679 0.433942195451584 no 1459 0.430268026007315 430 726316
SGTC_2729 fluphenazine 10.66 µM 0.175195009146143 0.434127060833987 no 1460 0.430463202904926 476 3372 An atypical antipsychotic.
SGTC_851 0394-0702 453 µM 0.174950964580364 0.434217873778222 no 1461 0.430559081911107 456 762646
SGTC_2281 7943571 200 µM 0.174290348449989 0.434463717168317 no 1462 0.430818641989753 479 1244024
SGTC_3204 9114183 49.47 µM 0.17385588717779 0.434625412527847 no 1463 0.430989360752942 422 17027248
SGTC_489 paxilline 115 µM 0.173535654317185 0.434744602000307 no 1464 0.431115202453562 461 105008 A toxic potassium channel blocker.
SGTC_3295 9122362 53.5725 µM 0.172801961563549 0.435017702040452 no 1465 0.431403547567847 461 4730473
SGTC_2426 5582046 32.21 µM 0.172277349743949 0.43521299558968 no 1466 0.431609745199771 445 2251934
SGTC_1436 4092-1007 8.32 µM 0.171086166260791 0.435656487689992 no 1467 0.432078006611459 451 2881121
SGTC_2636 apigenin dimethyl ether 100 µM 0.170934023469357 0.435713138142132 no 1468 0.432137821747309 469 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2043 5101342 149 µM 0.170190332509617 0.435990070843031 no 1469 0.432430227174336 459 678451
SGTC_1152 3909-8331 15.9 µM 0.169057398214475 0.436412008720711 no 1470 0.432875746913768 476 16001939
SGTC_2403 6032726 181.2 µM 0.168549473842915 0.436601198140018 no 1471 0.433075512921038 463 2881040
SGTC_2477 5967686 25.23 µM 0.168106508007799 0.436766203932431 no 1472 0.433249744782276 451 776118
SGTC_451 chloral hydrate 100 µM 0.167394094310392 0.437031602738072 no 1473 0.433529985837086 482 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.165419783410227 0.437767249748544 no 1474 0.434306791633896 488 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2144 5628481 200 µM 0.165094676802647 0.43788840826031 no 1475 0.434434731407993 476 2818399
SGTC_1237 0330-0133 46.1 µM 0.164851898669083 0.437978888956747 no 1476 0.43453027679271 470 X1237 YHR072W ERG7
SGTC_1849 st056239 19.2 µM 0.164529263208924 0.438099136603283 no 1477 0.434657255961585 480 5393181
SGTC_1850 st056238 17 µM 0.16429363422748 0.438186960166949 no 1478 0.434749996376948 492 5393177
SGTC_2971 9092186 9.93 µM 0.161873499119219 0.439089167656205 no 1479 0.435702736098814 410 25236400
SGTC_3338 9144300 39.5675 µM 0.160534463728576 0.439588485923205 no 1480 0.436230037765966 455 4901274
SGTC_3319 9138450 16.7555 µM 0.160381274804885 0.439645615296257 no 1481 0.436290369609951 489 2029690
SGTC_1764 st044502 93.5 µM 0.160351476031529 0.439656728420976 no 1482 0.43630210571521 444 8407
SGTC_1092 toremifene 6.32 µM 0.159573828104464 0.439946760447537 no 1483 0.436608398452685 493 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_875 0709-0210 25.7 µM 0.159488205065311 0.4399786964389 no 1484 0.43664212518578 482 6251364
SGTC_2320 7373003 200 µM 0.158174212666242 0.440468842944581 no 1485 0.437159761621693 452 5415828
SGTC_1476 4112-3294 3.34 µM 0.15810918043292 0.440493103696234 no 1486 0.437185383333584 488 704369
SGTC_1701 st028638 40.4 µM 0.15788599640335 0.440576365833766 no 1487 0.437273316453241 465 3490878
SGTC_2749 bexarotene 57.39 µM 0.157038033953868 0.440892734821259 no 1488 0.437607436599626 463 82146 An retinoic acid receptor inhibitor.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.156404724623479 0.441129042820715 no 1489 0.43785700664818 455 4330530
SGTC_1522 st012842 45.6 µM 0.156236288427577 0.441191895293601 no 1490 0.437923386955368 500 3491067 YOR116C RPO31
SGTC_2591 skatole 100 µM 0.155707912073846 0.441389070122226 no 1491 0.438131630155558 482 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_49 0717-0965 32.132 µM 0.155576008336655 0.441438295063634 no 1492 0.438183618609224 477 5889349 YGL099W LSG1
SGTC_2012 4023501 200 µM 0.155573189538656 0.441439347016155 no 1493 0.438184729620091 483 3477460
SGTC_1883 5-benzylidenerhodanine 20 µM 0.155538600509869 0.441452255394426 no 1494 0.438198362700103 476 1273210
SGTC_3013 9080133 71.4286 µM 0.155065157681161 0.441628947119009 no 1495 0.438384975015339 459 17050193
SGTC_175 3793-3120 23.7 µM 0.154595312624028 0.441804307618107 no 1496 0.438570182777128 492 5322297
SGTC_3197 9113331 49.47 µM 0.151647571563578 0.442904753364343 no 1497 0.439732455299929 445 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1090 efavirenz 20.7 µM 0.150824524033015 0.443212091134818 no 1498 0.440057070090626 462 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1706 st031321 9.9705 µM 0.150099862267005 0.443482718539174 no 1499 0.440342914324596 455 6103185
SGTC_3182 9108849 49.47 µM 0.149490776327062 0.443710204154191 no 1500 0.440583193506949 460 17133045
SGTC_2781 5567276 71.43 µM 0.147062847407923 0.444617187402395 no 1501 0.441541207224085 455 2853274
SGTC_596 1155-0152 116 µM 0.146432091005393 0.44485286201173 no 1502 0.441790147690916 495 280313
SGTC_1128 3448-9350 235 µM 0.1462181302465 0.444932810330518 no 1503 0.441874596756163 426 619386
SGTC_354 2783-3500 4.88 µM 0.146038296832679 0.445000008399478 no 1504 0.44194557800077 465 6740761
SGTC_2391 6285546 200 µM 0.145596320525737 0.445165167702817 no 1505 0.442120036413628 492 846083
SGTC_751 0833-0568 350 µM 0.142303332418587 0.446396001133834 no 1506 0.443420207212905 488 6954252
SGTC_1149 3909-7961 23.3 µM 0.14047763766363 0.447078621801797 no 1507 0.444141309919457 492 735261
SGTC_141 0443-0274 32.331 µM 0.1403187556009 0.447138034676743 no 1508 0.444204073050898 471 1627241
SGTC_2067 5224629 34.075 µM 0.139854539483251 0.447311631952526 no 1509 0.444387460209376 453 2835000
SGTC_1982 st072467 71.9 µM 0.139516036618536 0.447438224132606 no 1510 0.44452119224017 459 3163533
SGTC_2322 7413319 38.22 µM 0.139027937839811 0.447620771121027 no 1511 0.44471403611342 480 1840400
SGTC_852 0418-0143 439 µM 0.138859641771482 0.447683715750828 no 1512 0.444780531562944 481 5369229
SGTC_883 0850-0245 24.6 µM 0.138354368592043 0.447872701534271 no 1513 0.444980179347702 491 6823229 YPR165W RHO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.136214272636241 0.448673285779497 no 1514 0.445825946200051 481 165506
SGTC_2149 5554786 194.827 µM 0.134414706020796 0.449346644020295 no 1515 0.446537326718631 462 745063 YPR165W RHO1
SGTC_942 3253-1115 227 µM 0.133743998726481 0.44959764536147 no 1516 0.446802505867419 486 46497897
SGTC_2944 9067346 25.62 µM 0.133183398759887 0.449807456296283 no 1517 0.447024169874467 469 6473075
SGTC_1776 st049249 45.9 µM 0.130005701283549 0.450997009324327 no 1518 0.448280958001623 488 1822314
SGTC_339 3091-4833 71.4 µM 0.129662883075881 0.451125367875014 no 1519 0.448416574805487 482 3240077
SGTC_1660 st012960 28.1 µM 0.128681750526471 0.451492753318551 no 1520 0.448804738153362 499 24207266
SGTC_246 cycloheximide 667 µM 0.126876395099879 0.452168877664403 no 1521 0.449519114808254 494 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2011 4012611 177 µM 0.126652913586911 0.452252583500526 no 1522 0.449607557564491 490 2049887
SGTC_3062 9077494 49.47 µM 0.12660156560382 0.452271816379522 no 1523 0.44962787887056 457 16459633
SGTC_171 k064-0041 9.68 µM 0.126048503914369 0.452478978024231 no 1524 0.44984676507854 465 53325
SGTC_2930 9013230 14.89 µM 0.125288470151584 0.452763686789176 no 1525 0.450147589872618 477 2995857
SGTC_1785 bathophenanthroline 24 µM 0.123935425493001 0.453270597538004 no 1526 0.450683201840103 472 72812 An iron chelator.
SGTC_1621 st003705 32.4 µM 0.123331829864699 0.453496755936781 no 1527 0.450922168322017 466 24207032
SGTC_1145 3546-0597 10.2 µM 0.123255584881763 0.453525324884205 no 1528 0.450952355353564 475 875334
SGTC_735 3076-0345 636 µM 0.122967930773043 0.453633110863009 no 1529 0.451066246365778 504 2888990
SGTC_1752 st044819 83.042 µM 0.12238855087716 0.45385021886624 no 1530 0.451295652710957 476 441209 YML126C ERG13
SGTC_2496 diffractaic acid 79.83 µM 0.12216586903288 0.453933666943621 no 1531 0.451383828255534 466 94870 An apoptosis inducer which activates caspases.
SGTC_3043 9092303 49.47 µM 0.119247102403603 0.4550276359218 no 1532 0.452539795262284 470 25236084
SGTC_748 act1.228 77.9 µM 0.118978888653377 0.455128181077112 no 1533 0.452646040687393 467 4421505 YNR035C ARC35
SGTC_989 1501-0895 10.3 µM 0.118799161026742 0.45519555709208 no 1534 0.452717236690796 497 2830112
SGTC_917 harmaline 728.087 nM 0.11836824721886 0.455357102640234 no 1535 0.45288794196044 472 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_908 3448-7491 47.7 µM 0.117953148666151 0.455512726178451 no 1536 0.453052390296257 484 1203031
SGTC_2460 5552655 174.22 µM 0.117680089282967 0.455615101898179 no 1537 0.453160571796917 450 5401989
SGTC_1362 1611-0397 101 µM 0.116144128212928 0.456191020808679 no 1538 0.453769158091491 488 27816
SGTC_857 0438-0306 1.35 µM 0.112866669228633 0.45742023231154 no 1539 0.455068130769244 482 4686136
SGTC_2104 5389443 200 µM 0.112483565420004 0.45756394227712 no 1540 0.455219999967561 483 2244536
SGTC_2420 aureobasidin a 50 nM 0.111858291454301 0.457798507063161 no 1541 0.455467883793083 448 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1289 0976-0073 69.1 µM 0.111740469533668 0.457842708334629 no 1542 0.45551459509997 497 3391136
SGTC_2303 7774051 200 µM 0.111532897711028 0.457920580837825 no 1543 0.455596889865507 497 2953184
SGTC_1804 st050076 49.1 µM 0.109581142494586 0.458652878586841 no 1544 0.45637078334472 499 3895976
SGTC_223 busulfan 5 mM 0.108929497824131 0.45889740677123 no 1545 0.456629204985158 500 2478 A DNA alkylator.
SGTC_1414 3917-0015 5.4 µM 0.108685158146373 0.45898909869521 no 1546 0.456726107098306 510 6618702
SGTC_605 1315-0399 119 µM 0.108452508216138 0.459076405903729 no 1547 0.456818375592991 479 24020461
SGTC_3326 9140064 16.379 µM 0.106847979830649 0.459678595413028 no 1548 0.457454791457592 481 1868434
SGTC_2399 5884133 200 µM 0.1061727283226 0.459932049254078 no 1549 0.457722654133602 471 722445
SGTC_3349 9149703 23.001 µM 0.104242342219116 0.460656703957881 no 1550 0.458488516378039 493 4910494
SGTC_624 k048-0052 28 µM 0.102418918913348 0.461341325567176 no 1551 0.459212083756838 476 6835531
SGTC_581 0958-0271 211 µM 0.101821491705456 0.461565660309995 no 1552 0.459449183197147 482 4591145
SGTC_2427 5545055 42.75 µM 0.100413639020186 0.462094359179903 no 1553 0.460007971060682 484 5372858
SGTC_1684 st024538 14.6195 µM 0.0987936491814585 0.462702805940798 no 1554 0.460651055522447 501 6732859
SGTC_2089 5281248 129.67 µM 0.0965221838614382 0.463556084940045 no 1555 0.461552928004103 479 2737878
SGTC_1843 st055809 45.5 µM 0.0951254131867735 0.46408086722923 no 1556 0.462107606398525 482 16413835
SGTC_832 4083-0019 164 µM 0.0936079494850122 0.464651066034744 no 1557 0.462710297285063 507 1990758
SGTC_2786 7743617 45.45 µM 0.0933446666495835 0.464750004034513 no 1558 0.462814874053517 501 583674
SGTC_2198 6589944 200 µM 0.0925435511702782 0.465051065383837 no 1559 0.463133095413819 479 5290268
SGTC_2690 usnic acid 100 µM 0.092225085815571 0.465170751086735 no 1560 0.463259603689208 502 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1417 3966-0327 90.4 µM 0.0921314207516765 0.465205952906843 no 1561 0.463296812229784 504 651118
SGTC_2112 5488546 200 µM 0.0910333136408468 0.465618670976141 no 1562 0.463733060243379 508 600757
SGTC_2600 tangeritin 87.95 µM 0.0909260917093888 0.465658971792171 no 1563 0.463775658938651 503 68077 A bioactive flavone.
SGTC_53 0973-0023 39.979 µM 0.0905854158429893 0.465787021768693 no 1564 0.463911010377339 505 674768
SGTC_877 0771-0151 33.1 µM 0.086992856821718 0.467137571467947 no 1565 0.465338595006633 503 6166523
SGTC_3104 9120930 49.47 µM 0.0868115451101796 0.46720574208994 no 1566 0.465410655300428 514 17014836
SGTC_1740 st038286 13.222 µM 0.0867432915227717 0.467231404716318 no 1567 0.465437782212538 497 716786
SGTC_1546 5-methoxyflavanone 78.7 µM 0.0860203642716189 0.467503226051076 no 1568 0.46572511443946 505 147795
SGTC_1655 st012546 55.1 µM 0.0845145764517166 0.468069452214723 no 1569 0.466323656985855 511 720985 YLR208W SEC13
SGTC_1844 rapamycin 4 nM 0.0842149244326637 0.468182139056524 no 1570 0.4664427761799 511 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1640 st009078 66.4 µM 0.0833684263829108 0.468500486019871 no 1571 0.466779296593721 512 690618
SGTC_2195 6536160 144.242 µM 0.0822068323724459 0.468937365518761 no 1572 0.467241120195088 492 3834386
SGTC_1862 st057513 3.81 µM 0.081729035744181 0.469117077359694 no 1573 0.467431094203375 511 5393163
SGTC_2805 7950783 58.44 µM 0.0800405044455363 0.469752228422545 no 1574 0.468102520702194 492 1178958 YDL195W SEC31
SGTC_103 0844-0104 51.839 µM 0.0797369817288489 0.469866408501242 no 1575 0.468223222957615 498 5375804
SGTC_1901 st060216 58.6 µM 0.0794582500341145 0.4699712648023 no 1576 0.468334069109944 488 688792
SGTC_2395 5646831 180.19 µM 0.0782280628043425 0.470434074706703 no 1577 0.468823319761775 509 6808628
SGTC_2340 7987427 183.45 µM 0.0775729989704594 0.470680533228755 no 1578 0.469083860670956 502 2239331
SGTC_1181 1222-0449 220 µM 0.0772962901415986 0.470784644399644 no 1579 0.469193921058796 500 658318
SGTC_296 1222-0039 74.9 µM 0.0768720660597477 0.470944261779065 no 1580 0.469362659914052 504 5984176
SGTC_1534 6-azauridine 81.6 µM 0.0764517139037349 0.471102426922665 no 1581 0.469529864104604 518 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2255 7941087 197.44 µM 0.0761637986600151 0.471210762901188 no 1582 0.469644391742252 510 935561
SGTC_1600 coumarin 106 71.1 µM 0.0756394871689582 0.471408054894777 no 1583 0.469852960108257 525 100336 A hepatotoxic, DNA x-linker.
SGTC_827 3253-0474 693 µM 0.0734032239257359 0.472249611567328 no 1584 0.470742626098334 498 5402065
SGTC_1170 0310-0127 64.8 µM 0.0719779302869622 0.472786046837785 no 1585 0.471309735683171 512 774975
SGTC_2462 5162487 171.77 µM 0.0708511405231637 0.47321016971329 no 1586 0.471758114903308 516 2259986
SGTC_1710 st031758 61.5 µM 0.0699889549420561 0.473534716296632 no 1587 0.472101225379461 526 5394341
SGTC_3154 9100113 49.47 µM 0.0696806315371492 0.473650780629145 no 1588 0.472223929049471 503 25237525
SGTC_2892 9047358 58.44 µM 0.0693994822076545 0.473756617584666 no 1589 0.472335820532897 506 6466771
SGTC_1355 1499-0035 1.68 µM 0.0674145915611844 0.474503869874148 no 1590 0.473125826614547 505 1548538
SGTC_310 1273-0058 1.06 µM 0.0673228861775566 0.474538396411579 no 1591 0.47316232884181 508 2734232
SGTC_1127 asiatic acid 681.4 nM 0.067044781876336 0.474643102213111 no 1592 0.473273026297695 489 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1920 st075728 45.7 µM 0.0652231665625673 0.475328980292146 no 1593 0.473998158074427 524 3400306
SGTC_1726 st035556 14.5795 µM 0.0651373445511329 0.475361295979305 no 1594 0.474032323451013 460 5919439
SGTC_1123 mangostin 811.285 nM 0.0640759044485051 0.475760987269741 no 1595 0.474454893937384 519 5281650 An antioxidant.
SGTC_1027 k015-0025 8.67 µM 0.0636529403068317 0.475920263634827 no 1596 0.474623288452574 479 3598955
SGTC_18 0111-0177 500 nM 0.0628019063072851 0.47624075066723 no 1597 0.474962123927018 514 721752
SGTC_2078 5212016 200 µM 0.0624261571562843 0.476382257238635 no 1598 0.475111732590015 529 1899708
SGTC_2289 7946404 165.07 µM 0.0606084314210692 0.477066851781696 no 1599 0.475835529283998 502 1246120 YPR165W RHO1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0595500543125482 0.477465490635652 no 1600 0.476256999303484 514 6708739 YPR165W RHO1
SGTC_2274 7947094 46.08 µM 0.0590025791279135 0.477671706615411 no 1601 0.476475026922889 531 2971028
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0572667656600756 0.478325569989147 no 1602 0.477166347025288 513 688664
SGTC_131 0141-0277 33.849 µM 0.0569504265525279 0.478444738067686 no 1603 0.47729234244189 508 1547771
SGTC_1962 st076595 64.5 µM 0.0561979564968649 0.478728208723188 no 1604 0.477592054535651 511 279619
SGTC_2598 perillyl alcohol 100 µM 0.0559726098410834 0.478813103456453 no 1605 0.47768181356197 519 10819 An apoptosis inducer.
SGTC_1510 1123-0200 71.5 µM 0.0558235401629503 0.478869262930455 no 1606 0.477741190921653 523 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2938 9059746 27.26 µM 0.0554646289995027 0.479004478345393 no 1607 0.477884154261353 516 6471769
SGTC_1803 st050068 52.4 µM 0.0553900794799049 0.479032564273657 no 1608 0.477913849566811 523 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2998 9066762 71.4286 µM 0.0548928168020855 0.479219906620345 no 1609 0.47811192730686 528 4945196
SGTC_3185 9108267 49.47 µM 0.0537168494991829 0.479662967259779 no 1610 0.478580379112229 517 4910486
SGTC_2626 ethyl orsellinate 100 µM 0.0537104511479864 0.479665377989207 no 1611 0.478582928005415 527 75653 A natural product.
SGTC_184 1494-0393 24.714 µM 0.0536703692711088 0.479680479796757 no 1612 0.47859889533 517 3090647
SGTC_695 3505-6186 243 µM 0.0535447549304525 0.479727808198394 no 1613 0.478648936246736 516 1819379
SGTC_2348 9022543 33.42 µM 0.0526309844076624 0.480072103071895 no 1614 0.47901296459408 532 3162678 YDL140C RPO21
SGTC_2926 9010726 65.15 µM 0.0517687028263233 0.480397011332301 no 1615 0.479356496812528 507 2994293
SGTC_401 neomycin 50 µM 0.051136728130944 0.480635148091147 no 1616 0.479608284724406 482 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2260 7964312 200 µM 0.0490932673280737 0.481405199101064 no 1617 0.480422484416741 503 231951
SGTC_1396 3511-0007 98.6 µM 0.0487355922134605 0.481539991424798 no 1618 0.480565005540275 521 X1396
SGTC_2396 5342950 42.78 µM 0.0478661254787493 0.481867664705886 no 1619 0.480911468191449 532 1886677
SGTC_593 1203-0218 61.7 µM 0.0467834101039298 0.482275721452381 no 1620 0.481342925687069 529 3666956
SGTC_3165 9101544 49.47 µM 0.0466500876207644 0.48232596968895 no 1621 0.481396055653977 524 5002184
SGTC_1783 st039459 87.517 µM 0.0464998184719182 0.482382605332284 no 1622 0.481455939384919 536 729761
SGTC_2378 9074213 121.43 µM 0.046146458466233 0.482515786238822 no 1623 0.481596758462454 531 657714
SGTC_2927 9011802 47.9 µM 0.0449039333024092 0.482984107680027 no 1624 0.482091940843473 516 43912568
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0440199805961652 0.483317293537085 no 1625 0.482444238545649 519 688761
SGTC_2968 9090663 33.37 µM 0.043665120646777 0.483451053210022 no 1626 0.482585671188262 530 25236811
SGTC_1307 1187-1599 12.2 µM 0.0436292113784049 0.483464588828553 no 1627 0.482599983274378 530 1538471
SGTC_1190 1486-1332 13 µM 0.043055516024323 0.483680839792117 no 1628 0.482828639730669 533 4150046
SGTC_192 3455-0609 60.9 µM 0.0422272342368857 0.483993064010558 no 1629 0.483158776068574 518 3769639
SGTC_3294 9122953 26.2835 µM 0.0405635555362557 0.484620223985899 no 1630 0.483821919349268 532 16459826
SGTC_457 grayanotoxin iii 135 µM 0.0399244670516005 0.484861152530421 no 1631 0.484076672382316 535 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1911 st060208 74.3 µM 0.0395167508440308 0.485014859448705 no 1632 0.484239199352635 514 688783
SGTC_55 0767-0285 6.563 µM 0.0373960146886527 0.485814401494335 no 1633 0.485084625133797 527 3116166
SGTC_2188 6126565 140.678 µM 0.037223283742095 0.485879525612908 no 1634 0.485153486866636 529 874518
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0354256725957578 0.486557294415322 no 1635 0.485870156892721 534 688801
SGTC_1020 4335-0961 93.3 µM 0.0342684398868475 0.486993636492229 no 1636 0.486331545701566 522 669075
SGTC_470 aa-861 153 µM 0.0317142449921502 0.487956766563009 no 1637 0.487349967370245 532 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2908 7930301 100 µM 0.0314167984460841 0.488068931711823 no 1638 0.487468572270569 520 2223178
SGTC_2082 5219693 150 µM 0.0312200974429369 0.488143106893674 no 1639 0.487547006142019 535 2834649
SGTC_1657 st012939 43.4 µM 0.03119013769092 0.488154404635478 no 1640 0.487558952535936 539 24207257
SGTC_567 1080-0542 68.4 µM 0.0308908452872931 0.488267267515187 no 1641 0.487678295421491 537 5950415
SGTC_400 oxethazaine 37.5 µM 0.029964344917747 0.488616655836421 no 1642 0.488047744513806 528 4621 A local anesthetic.
SGTC_3242 9133940 49.47 µM 0.0293200172926427 0.488859640449508 no 1643 0.488304681136824 530 17248444
SGTC_686 1319-0111 510 µM 0.0283450316576391 0.489227328478283 no 1644 0.488693482472339 531 4562600
SGTC_2782 7736369 71.43 µM 0.0282375539271006 0.489267861205363 no 1645 0.488736342727184 530 2950836 YOL077C BRX1
SGTC_2767 sibutramine 71.45 µM 0.0279668376473744 0.489369956046022 no 1646 0.488844300259577 538 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_105 0111-0055 734.78 µM 0.0272645307975331 0.489634819247499 no 1647 0.489124373334171 509 5179370
SGTC_2925 9010536 32.5 µM 0.0265873232223311 0.489890221010336 no 1648 0.489394442144928 530 2994177
SGTC_526 4469-0568 170 µM 0.0265044057090999 0.489921492771246 no 1649 0.489427509793576 513 2901964
SGTC_299 1273-0059 1.44 µM 0.0247717234664613 0.490574975657867 no 1650 0.490118522769938 533 2848077
SGTC_2704 st078022 71.1 µM 0.0235399656580151 0.491039549868061 no 1651 0.490609779661601 538 54697681
SGTC_1627 st003713 25.6 µM 0.0234027966750378 0.49109128577933 no 1652 0.490664487097032 529 16195070 YER133W GLC7
SGTC_2612 dictamnine 15.46 µM 0.0230207455365288 0.491235384476931 no 1653 0.49081686239414 537 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1015 4130-4525 82 µM 0.0223431892642548 0.491490942010357 no 1654 0.491087098709931 523 1363237
SGTC_2753 fluvastatin 17.09 µM 0.0205762866254664 0.492157390321897 no 1655 0.491791828496357 530 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_229 benomyl 22.8748 µM 0.0201850279998442 0.49230497004207 no 1656 0.491947885689497 525 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2473 5854593 8.94 µM 0.0195412896289175 0.492547785447413 no 1657 0.492204649481302 544 2872951
SGTC_892 0929-0076 29 µM 0.0191292345447353 0.492703212346808 no 1658 0.492369004949863 539 5751038
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0180681965642843 0.49310344019825 no 1659 0.492792224636766 539 66535 A nucleotide analog.
SGTC_3011 9081274 71.4286 µM 0.017480233163208 0.493325225405204 no 1660 0.493026751044371 538 6625322
SGTC_518 1021-0119 62.6 µM 0.0140251995473548 0.494628535322957 no 1661 0.494404938340668 531 1097762
SGTC_62 0180-0423 3.232 µM 0.00979201529697363 0.496225456443179 no 1662 0.496093613514176 539 30102 YGL099W LSG1
SGTC_603 3794-0023 45.9 µM 0.00962042217417854 0.496290189465917 no 1663 0.496162066041245 542 3802260
SGTC_1977 st070720 65.3 µM 0.00925154988226753 0.496429345828574 no 1664 0.49630921824252 537 682188
SGTC_951 1171-0579 82.7 µM 0.00765320973062501 0.497032321379199 no 1665 0.496946840862449 542 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_263 alizarin 107.927 µM 0.0072763978539135 0.497174475105866 no 1666 0.49709716286266 543 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1578 josamycin 24.2 µM 0.00697768394357405 0.497287166330806 no 1667 0.497216329444241 537 5282165 A P450 substrate.
SGTC_395 anisomycin 6.25 µM 0.00685742344252696 0.497332535230993 no 1668 0.497264305294845 541 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_969 1313-0238 134 µM 0.00536973472833836 0.497893776213627 no 1669 0.497857796077067 545 5212874
SGTC_1344 1488-0097 29.1 µM 0.0051111898274212 0.497991314543942 no 1670 0.497960939152848 544 747966
SGTC_292 k038-0015 474 µM 0.00409392180137869 0.498375088934579 no 1671 0.498366766062994 545 46368540
SGTC_1921 5740136 50 µM 0.00403634587545401 0.498396810068497 no 1672 0.498389735344388 546 1774243
SGTC_65 0798-0905 34.986 µM 0.00372489018133372 0.498514310141347 no 1673 0.498513987253171 545 3602145
SGTC_679 0422-0091 41.4 µM 0.00108980165588496 0.499508430300517 no 1674 0.499565232128276 547 627384 YHR062C RPP1
SGTC_3000 9075062 71.4286 µM 0.000716183864188173 0.499649382683216 no 1675 0.499714284000459 547 17057871
SGTC_2539 epi(13)torulosol 80 µM 9.7838552815265e-05 0.499882661931902 no 1676 0.499960968064691 548 6708597
SGTC_3305 9127027 53.8275 µM -3.2455775270459e-05 0.49993181726182 no 1677 0.499987052019004 548 41905295
SGTC_1681 tripelennamine 100 µM -0.000213185390362098 0.5 no 1678 0.499914951334865 548 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1114 scopoletin 1.73284 µM -0.000387883118273317 0.499934092874371 no 1679 0.499845257028147 548 5280460 A coumarin with genotoxic properties.
SGTC_2985 9022375 71.43 µM -0.00114915034474052 0.499646894365507 no 1680 0.499541555441845 552 4939335
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.00121878291822191 0.499620624528404 no 1681 0.499513776083666 548 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_197 4544-0043 41.561 µM -0.00248774327413717 0.499141892347002 no 1682 0.499007535048868 549 896523
SGTC_820 1582-0060 59.9 µM -0.00563436414785789 0.497954794545616 no 1683 0.497752225811243 556 3848840
SGTC_2772 vinpocetine 57.06 µM -0.00592657364507072 0.497844556013048 no 1684 0.497635653036072 551 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1205 4161-2785 76 µM -0.00599979981871518 0.497816930838078 no 1685 0.497606440538777 559 3498106
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.00637875564831326 0.497673966811507 no 1686 0.497455261932489 560 5024745
SGTC_232 clozapine 119 µM -0.00755067543978953 0.497231852949992 no 1687 0.496987744944305 554 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1559 coumarin 343 70.1 µM -0.00769985668835565 0.497175573650197 no 1688 0.496928231967071 553 108770 A hepatotoxic, DNA x-linker.
SGTC_2471 5466956 24.79 µM -0.00872768528014621 0.496787822259341 no 1689 0.496518201534645 553 724419
SGTC_147 4466-0538 29.23 µM -0.00884659327326074 0.49674296405443 no 1690 0.496470765940119 566 6742687 YHR072W ERG7
SGTC_169 k015-0017 16.025 µM -0.00896107970384697 0.496699773929006 no 1691 0.496425094272873 550 1840002
SGTC_2687 chenodiol 100 µM -0.00958599604585235 0.496464024281873 no 1692 0.496175799446111 552 5702181 A cholesterol synthesis inhibitor.
SGTC_1161 k007-0610 110 µM -0.00995598348216612 0.496324447123618 no 1693 0.496028202861247 551 5843850
SGTC_769 0302-0231 76 µM -0.00998810360347134 0.496312329881106 no 1694 0.496015389423917 553 571869 YER009W NTF2
SGTC_1998 st075797 76.8 µM -0.0100698683128239 0.49628148434635 no 1695 0.495982771664719 551 24208315
SGTC_1619 st003326 88.7 µM -0.0102480601600517 0.496214261989141 no 1696 0.495911687071152 552 2849032
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0120315722074798 0.495541443483474 no 1697 0.495200212948859 557 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1016 4226-1401 38 µM -0.0131823176864963 0.495107338727224 no 1698 0.494741168429208 552 2901613
SGTC_2621 lithochol-11-enic acid 100 µM -0.0132032662530101 0.495099436187062 no 1699 0.494732811887571 556 6708711
SGTC_426 0988-0037 14.6 µM -0.0137954183586796 0.494876056277694 no 1700 0.494496598903433 556 5383008
SGTC_3033 9090887 49.47 µM -0.0139365099096946 0.494822831981466 no 1701 0.494440316929158 546 19325384
SGTC_2408 sulbentine 18.36 µM -0.014551099267562 0.494590990086036 no 1702 0.494195156124184 561 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_601 0986-0029 62.9 µM -0.0159354570094657 0.494068774834393 no 1703 0.493642941493168 553 24747981
SGTC_956 1185-0240 191 µM -0.0161600659992739 0.493984047496588 no 1704 0.493553347008169 560 1416193
SGTC_1605 st000082 49.1 µM -0.0162309435654215 0.493957311011629 no 1705 0.493525074658389 566 1114022
SGTC_143 4032-1194 15.74 µM -0.0164191329337644 0.493886322218828 no 1706 0.493450007966307 555 1806963
SGTC_378 3970-0959 8.33 µM -0.0173956158008771 0.493517976514534 no 1707 0.493060503355739 559 6615653
SGTC_326 k292-0812 17.5 µM -0.017401014047736 0.493515940220411 no 1708 0.493058350092749 557 3579357
SGTC_1171 0368-0077 21.4 µM -0.018523185014713 0.493092645403671 no 1709 0.49261074088514 552 3239779
SGTC_2623 humulene 100 µM -0.0188102700057825 0.492984355123932 no 1710 0.492496230496649 559 6187145 An anti-inflammatory.
SGTC_1107 amlodipine 47 µM -0.0191592135261507 0.492852732111454 no 1711 0.492357047258109 555 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_176 1486-1328 72.834 µM -0.0192646917626185 0.492812945414732 no 1712 0.492314975295018 554 22310231
SGTC_2888 9058547 12.99 µM -0.0192825021780839 0.492806227281406 no 1713 0.492307871286849 560 16476514
SGTC_949 1165-0505 146 µM -0.0193680141498346 0.492773971979919 no 1714 0.492273763315519 552 6244267
SGTC_1247 0448-0043 5.84 µM -0.0201342179467073 0.492484960376708 no 1715 0.491968151849353 563 3089013 YGL099W LSG1
SGTC_847 0342-0274 5.54 µM -0.0205324529298111 0.492334747933269 no 1716 0.491809311917252 568 18097
SGTC_1980 st071811 45.7 µM -0.0207654944014186 0.492246846241733 no 1717 0.491716361639539 558 4974850
SGTC_1653 st012112 65 µM -0.0212615186906982 0.492059750441142 no 1718 0.491518520265445 559 720429
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0218928300431288 0.491821628136277 no 1719 0.491266722101263 554 641818
SGTC_1824 st053723 68.6 µM -0.0245543148595217 0.490817784254722 no 1720 0.490205229880759 565 675225
SGTC_996 3970-0799 1.8 µM -0.0248064176269983 0.490722700465842 no 1721 0.490104686054388 559 6615648 YGL040C HEM2
SGTC_3289 9119912 71.43 µM -0.0264890134261519 0.490088101664492 no 1722 0.48943364827082 572 17014829
SGTC_2954 9074818 52.69 µM -0.0271917799906937 0.489823057334403 no 1723 0.489153385950375 563 16648742
SGTC_2765 myclobutanil 7.74 µM -0.0276533486301614 0.489648981839254 no 1724 0.488969315929485 560 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_611 3453-1652 23.7 µM -0.0283498216269644 0.489386318512777 no 1725 0.488691572318684 556 1560575
SGTC_1267 0828-0272 9.49 µM -0.0311047343778612 0.488347394728557 no 1726 0.487593007005195 571 745334
SGTC_1326 1431-2094 10.8 µM -0.031831929973601 0.488073169979322 no 1727 0.487303041547874 579 616278
SGTC_1749 st037932 54.2 µM -0.0319144645778277 0.488042046614519 no 1728 0.487270131725463 566 594497
SGTC_1524 corynanthine 62.1 µM -0.0321999107611119 0.487934406924008 no 1729 0.487156313672902 594 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2571 chrysanthemic acid 100 µM -0.0325318157948259 0.487809249042766 no 1730 0.48702397205781 577 2743 An insecticide.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0330738254327618 0.487604865522003 no 1731 0.486807857802954 560 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_537 1334-0398 209 µM -0.033152803271388 0.487575084460928 no 1732 0.486776367473094 582 5846986
SGTC_3041 9091929 49.47 µM -0.0341879028886688 0.487184774283436 no 1733 0.486363656499769 561 25236887
SGTC_675 1309-0189 238 µM -0.034992763965792 0.48688128976489 no 1734 0.486042755429996 560 4246530
SGTC_1658 st012944 20 µM -0.0350944821115474 0.486842936002871 no 1735 0.486002200670382 568 24207260
SGTC_1944 st076371 56.9 µM -0.0358953387865434 0.486540969910013 no 1736 0.485682906291763 561 24208455
SGTC_1703 st026983 48.3 µM -0.0363890048273686 0.48635483506196 no 1737 0.485486090625544 571 1104023
SGTC_2441 5730946 39.09 µM -0.0366387940236334 0.486260654153462 no 1738 0.48538650556299 564 1774275
SGTC_200 k038-0079 37.545 µM -0.0369502238551483 0.486143233237545 no 1739 0.485262347109859 558 3436683
SGTC_710 3448-4187 58 µM -0.0371717840352793 0.486059697336151 no 1740 0.485174018068131 566 3946412
SGTC_2413 inermin 26.06 µM -0.0374435418007945 0.48595723603315 no 1741 0.485065677829329 604 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2377 9073351 62.6 µM -0.0385156294968897 0.485553034051711 no 1742 0.48463828509679 602 7337946 YHR072W ERG7
SGTC_495 decylubiquinone 155 µM -0.0386114360226023 0.485516913480903 no 1743 0.484600092232704 569 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2710 st078562 53.7235 µM -0.0393136824410131 0.485252159155377 no 1744 0.484320149019791 568 17250908
SGTC_511 blebbistatin 171 µM -0.0409149634362721 0.484648483786374 no 1745 0.483681844169744 574 3476986 A myosin inhibitor.
SGTC_1064 honokiol 6.76 µM -0.041997627032558 0.484240344577981 no 1746 0.483250294901724 575 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3187 9109394 49.47 µM -0.0420587841969935 0.484217290226012 no 1747 0.483225918261679 563 17098090
SGTC_3306 9127676 59.7925 µM -0.0431698021044833 0.483798480236015 no 1748 0.48278308853397 562 41905287
SGTC_101 0490-5701 117.494 µM -0.0440640112925812 0.483461411554228 no 1749 0.482426689867034 574 4661669
SGTC_160 3453-0671 289.699 µM -0.045018795455857 0.483101522424304 no 1750 0.482046163767197 580 5322268
SGTC_1994 st072947 40.9 µM -0.0452903409826656 0.482999170606615 no 1751 0.481937943159482 596 5286565 YDL195W SEC31
SGTC_1292 0kpi-0043 232 µM -0.0454807678238706 0.482927394974037 no 1752 0.481862052043683 578 3333905
SGTC_3151 9099821 49.47 µM -0.0462781296962048 0.482626859592257 no 1753 0.481544285301883 597 17174189
SGTC_421 streptovitacin 30 mM -0.0480897084874404 0.481944090485949 no 1754 0.480822374077323 589 91467 include heat shock
SGTC_3083 9117465 49.47 µM -0.048537675742497 0.481775263410923 no 1755 0.480643869456048 582 16420915
SGTC_561 1550-0330 72.9 µM -0.0488489617584058 0.481657949822456 no 1756 0.480519831440208 579 6812934
SGTC_1989 st071868 50.2 µM -0.049331815369473 0.481475981126411 no 1757 0.480327432688729 567 16414057
SGTC_26 0302-0163 425.158 µM -0.0506535807141816 0.480977879167893 no 1758 0.479800783177245 575 3100915
SGTC_3200 9114385 49.47 µM -0.0507820364309102 0.480929472718075 no 1759 0.47974960262883 575 17018030 YLR208W SEC13
SGTC_37 0566-0070 1.56 µM -0.0509691877944917 0.480858948270851 no 1760 0.479675036600308 576 1626686
SGTC_1448 4255-0083 152 µM -0.0517369123054371 0.48056965212076 no 1761 0.479369162422574 599 5399660
SGTC_2570 licareol 100 µM -0.0522658438595651 0.480370344561626 no 1762 0.479158434376769 595 443158
SGTC_810 3825-7150 143 µM -0.0528264095798208 0.480159122238161 no 1763 0.47893510953645 567 22330411 YGL099W LSG1
SGTC_965 1291-5240 308 µM -0.0536404426565272 0.479852402824964 no 1764 0.478610817148631 578 2834598
SGTC_373 0844-0104 25.9 µM -0.0539011597111829 0.479754169794563 no 1765 0.478506956347501 582 5375804
SGTC_1814 st052110 31.539 µM -0.0547438177478955 0.479436681350199 no 1766 0.478171280083263 587 674163
SGTC_2657 nystatin 74.44 µM -0.0548453421759985 0.479398430846846 no 1767 0.478130838453914 573 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1291 0993-0025 5.79 µM -0.0551727041375542 0.479275094732835 no 1768 0.478000437372721 579 4353356
SGTC_571 k831-0106 44.2 µM -0.055662327769166 0.479090629005136 no 1769 0.477805405517854 571 4783639
SGTC_2060 5238662 140 µM -0.0571724516271398 0.478521718146575 no 1770 0.477203911335939 582 790130
SGTC_1942 st076330 65.2 µM -0.0578367236431694 0.478271479904995 no 1771 0.476939342944153 609 24208414
SGTC_1345 1488-0192 31.4 µM -0.0588045654181612 0.477906899107227 no 1772 0.476553886038934 581 658348
SGTC_2851 9015922 71.43 µM -0.0589660099527922 0.47784608560922 no 1773 0.476489590556444 570 2996893
SGTC_2812 7970281 58.44 µM -0.0591098006217649 0.477791922466012 no 1774 0.476432326262734 595 2233435
SGTC_1730 st033808 45.1 µM -0.0614194550845943 0.476921977532364 no 1775 0.475512579345916 570 1045166
SGTC_568 1193-0097 7.48 µM -0.0615668982328295 0.476866445894048 no 1776 0.475453869148873 582 3646150
SGTC_2361 9034121 116 µM -0.0617855922906612 0.476784079792696 no 1777 0.475366788625892 592 6496917
SGTC_1214 0358-0031 63.7 µM -0.0625504204929063 0.476496032613674 no 1778 0.475062255384482 627 4301366
SGTC_2344 7990960 76.95 µM -0.0631375446859671 0.476274920081161 no 1779 0.474828488794375 590 140813
SGTC_1113 artemisinin 1.17947 µM -0.0633308578130198 0.47620211943867 no 1780 0.474751522046923 592 2240 An anti-malaria and mitochondrial poison.
SGTC_1723 st034307 2.5525 µM -0.0639766499017672 0.47595892352286 no 1781 0.47449440969478 571 867466
SGTC_2261 9010538 184.68 µM -0.0685280912220597 0.474245176003612 no 1782 0.472682629535024 645 6457250
SGTC_2006 4011487 200 µM -0.0687032693536763 0.47417922575827 no 1783 0.472612907893779 572 45595294
SGTC_867 0518-0118 155 µM -0.0694082850441558 0.473913811914667 no 1784 0.472332317157102 579 6848158
SGTC_355 1311-2252 105 µM -0.0694493565730475 0.473898350270812 no 1785 0.472315971431373 577 5338538
SGTC_100 0086-0128 49.5915 µM -0.0704465535143105 0.473522961126113 no 1786 0.471919119456587 608 93297
SGTC_25 0118-0223 35.662 µM -0.070631735514647 0.473453252988599 no 1787 0.471845426096082 578 5333628
SGTC_1748 st037455 53.6035 µM -0.0706936139800229 0.473429960233198 no 1788 0.471820801714207 575 580690
SGTC_3244 9134489 49.47 µM -0.0709780926343956 0.473322875817485 no 1789 0.471707595526436 587 16584271
SGTC_1413 3910-0535 34.4 µM -0.0720028618020956 0.472937144782454 no 1790 0.47129981518807 581 2876951
SGTC_2113 5491891 107.031 µM -0.0768574385053636 0.471110195540683 no 1791 0.469368478250623 601 789979
SGTC_2453 5731132 22.18 µM -0.077239166726404 0.470966562960443 no 1792 0.46921664207731 599 1362040
SGTC_2862 9027634 71.43 µM -0.0772849968306683 0.470949318756393 no 1793 0.469198413000874 579 5012562
SGTC_2597 laccaic acid a 100 µM -0.0777601490343246 0.470770539451663 no 1794 0.46900942344299 606 5491415 A textile dye.
SGTC_112 phenothiazine 287.218 µM -0.0781656076576232 0.470617987495585 no 1795 0.46884815969927 589 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_722 3534-0461 190 µM -0.0783822226070683 0.47053648887541 no 1796 0.468762007162128 579 658262
SGTC_2811 7967822 32.47 µM -0.0785176585955088 0.470485533433804 no 1797 0.468708142028987 591 2232244
SGTC_1001 4048-4355 44.4 µM -0.0804529870554405 0.46975745286174 no 1798 0.467938492933183 603 21824233
SGTC_1211 1056-0033 32.3 µM -0.0805184686523652 0.469732820101062 no 1799 0.467912454031703 587 6741922
SGTC_3324 9138759 60.749 µM -0.0825569038471485 0.468966063264842 no 1800 0.467101934994769 592 45595710
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0828096882133358 0.468870986458365 no 1801 0.467001432754531 575 551469
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0840350923876148 0.468410114877886 no 1802 0.466514265372739 598 5393153
SGTC_335 4077-0256 27.6 µM -0.0848917148157156 0.468087966333239 no 1803 0.466173739314941 604 3121989
SGTC_2905 7799065 20.05 µM -0.0850254604857111 0.46803767070648 no 1804 0.466120574729013 611 1296806
SGTC_3188 9110789 49.47 µM -0.0862595136310922 0.46757362395931 no 1805 0.465630060956505 601 849217
SGTC_3222 9128301 49.47 µM -0.0868680190930851 0.467344821000135 no 1806 0.465388210231453 580 4911358
SGTC_459 nigericin 15.3 µM -0.0872185555341027 0.467213021365317 no 1807 0.465248895188507 619 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3179 9107801 49.47 µM -0.0872508085165162 0.467200894614486 no 1808 0.465236076975653 583 4818259
SGTC_1255 0566-0045 221 µM -0.0878999934379995 0.466956815030868 no 1809 0.464978080910616 604 2788469
SGTC_2488 5268135 45.7 µM -0.0880317183225992 0.466907290817562 no 1810 0.46492573321015 598 1270356 YLR208W SEC13
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0880413355362397 0.466903675082395 no 1811 0.464921911336327 581 16623 A steroid.
SGTC_2846 9008642 19.48 µM -0.0885771667163961 0.466702225667711 no 1812 0.464708977531473 619 2992898
SGTC_547 1120-0019 610 nM -0.0893061625289726 0.466428168388061 no 1813 0.464419298325936 592 3676939
SGTC_36 0335-0881 14.2 µM -0.090561694818423 0.465956203387941 no 1814 0.463920434959975 588 23828853
SGTC_1175 0741-0056 27.6 µM -0.093012537210249 0.465035049949584 no 1815 0.462946800574287 598 765927
SGTC_580 1123-0028 41 µM -0.0933282814566404 0.464916390435549 no 1816 0.4628213823886 589 1677248 YPR107C YTH1
SGTC_957 1187-1561 14.1 µM -0.0933767642135646 0.464898170457564 no 1817 0.462802124662668 580 1538454
SGTC_964 1287-0107 19.4 µM -0.0942829828877134 0.464557624113022 no 1818 0.462442183691363 605 51516812 YPR165W RHO1
SGTC_1859 st055998 20 µM -0.0952348560123562 0.4641999493214 no 1819 0.462064142350708 625 676301
SGTC_2041 5107442 45.335 µM -0.0967752497849707 0.463621194076814 no 1820 0.46145243973463 586 793005
SGTC_3331 9141060 1.957 µM -0.0972507147739962 0.46344256832605 no 1821 0.461263647155485 603 4906567 YPR165W RHO1
SGTC_988 1497-1057 103 µM -0.097414977198971 0.463380858870875 no 1822 0.461198425606159 589 3533044
SGTC_2245 6637752 200 µM -0.0975431750693722 0.463332698616369 no 1823 0.461147524466483 597 681890
SGTC_705 1124-0212 310 µM -0.0978411392620391 0.463220764112205 no 1824 0.461029219836863 583 9554485
SGTC_96 0929-0093 37.281 µM -0.0981530971615393 0.46310357579255 no 1825 0.46090536279821 596 6991579
SGTC_2937 9044753 11.33 µM -0.0985689748727267 0.462947354532208 no 1826 0.46074025224541 582 6465530 YGL099W LSG1
SGTC_1472 k841-0093 193 µM -0.0991224004233357 0.462739473350943 no 1827 0.460520543352585 599 X1472
SGTC_720 r052-1644 49.9 µM -0.099531121650743 0.462585953445927 no 1828 0.460358289534853 606 1422863 YOR257W CDC31
SGTC_2054 5233173 129 µM -0.100780688251094 0.46211663801375 no 1829 0.459862278660692 595 6889
SGTC_2063 5246145 200 µM -0.100795051096906 0.462111243884576 no 1830 0.459856577743403 616 711240
SGTC_2158 5657123 3.6195 µM -0.101371237199981 0.461894856435342 no 1831 0.459627884111423 657 2858827
SGTC_633 0437-0093 97.7 µM -0.102951687998064 0.461301374145232 no 1832 0.459000657258461 596 2831118
SGTC_639 0833-0042 114 µM -0.10339489196622 0.461134960015108 no 1833 0.458824783020315 593 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_876 0720-0963 56.8 µM -0.103602610653764 0.461056968187669 no 1834 0.458742357906498 619 765861
SGTC_1519 esterone 74 µM -0.104087863052074 0.460874777031486 no 1835 0.458549811209726 600 698 A steroid.
SGTC_2185 6113692 200 µM -0.104988546363132 0.460536631444697 no 1836 0.45819244858385 607 874150
SGTC_1071 trifluoperazine 6.31 µM -0.105479230336434 0.460352424835151 no 1837 0.457997774917086 627 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1040 k898-0338 155 µM -0.105903316681134 0.460193226350636 no 1838 0.457829531269098 587 20969351
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.106699293649819 0.459894440468728 no 1839 0.457513771497325 601 803109
SGTC_54 0159-0055 9 µM -0.107867540185439 0.459455956814541 no 1840 0.457050383013161 638 3319099
SGTC_2147 5545932 89.7195 µM -0.108252522230853 0.45931147040802 no 1841 0.456897691493699 610 797404
SGTC_3232 9132874 49.47 µM -0.108752958117586 0.459123661417862 no 1842 0.45669921820481 609 3784940
SGTC_738 1315-0003 72.4 µM -0.110305171593094 0.458541188178087 no 1843 0.456083677978172 625 6251474
SGTC_228 caffeine 993.056 µM -0.111294512912348 0.458169980942377 no 1844 0.455691403218576 609 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1050 3232-1156 69.3 µM -0.111502502950103 0.458091946370445 no 1845 0.455608940455534 591 700529
SGTC_1447 4239-0816 81.9 µM -0.111581563690525 0.458062284454848 no 1846 0.455577595383053 602 1341554
SGTC_1296 1068-0102 11.9 µM -0.11230520315404 0.457790801124918 no 1847 0.455290708192422 619 767053
SGTC_2389 9091542 195.52 µM -0.113450247408995 0.457361262255133 no 1848 0.454836802573639 596 3626624 YOL127W RPL25
SGTC_628 1636-0253 16 µM -0.11447950739491 0.456975199867877 no 1849 0.454428845160531 611 4456143
SGTC_253 dyclonine 31.25 µM -0.115206620622909 0.456702493355105 no 1850 0.454140675561398 592 3180 An oral anasthetic.
SGTC_301 4119-0100 24.5 µM -0.115537569729903 0.456578376409961 no 1851 0.454009521757461 620 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2920 7982904 15.77 µM -0.11621093650655 0.456325854517367 no 1852 0.453742684701269 609 6456808
SGTC_2662 daunorubicin 22.37 µM -0.116842669831868 0.456088961781436 no 1853 0.453492364837795 576 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1033 k072-0102 21.3 µM -0.117355619602534 0.455896622991224 no 1854 0.453289125705251 597 5965931
SGTC_774 k060-0086 136 µM -0.1178175429036 0.45572342624164 no 1855 0.453106114566538 608 5911235
SGTC_833 3852-0053 558 µM -0.118432964205075 0.455492688957272 no 1856 0.452862303955462 618 3123681
SGTC_1313 1220-0047 237 µM -0.11874905057311 0.455374185873424 no 1857 0.452737087354931 592 3528706
SGTC_1317 1273-0028 910 nM -0.119991814894995 0.454908303062243 no 1858 0.452244815939132 620 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2795 7780010 54.55 µM -0.120348947259003 0.454774434068928 no 1859 0.452103365771633 609 953673
SGTC_3293 9120939 62.045 µM -0.120540527850697 0.454702623312056 no 1860 0.45202748854748 610 934087
SGTC_1245 0418-0076 17.2 µM -0.120976039651408 0.454539384562822 no 1861 0.451855006687689 630 6790114
SGTC_607 4491-0986 66.8 µM -0.121726681539709 0.454258046633497 no 1862 0.451557740777462 602 698981 YDR232W HEM1
SGTC_2487 5918373 44.05 µM -0.121881543556143 0.454200007747398 no 1863 0.451496416374848 589 2876279
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.122145787589224 0.454100977139927 no 1864 0.451391780042119 619 688751
SGTC_3082 9117008 49.47 µM -0.122312227389979 0.454038602041193 no 1865 0.451325874325308 587 41448529
SGTC_2003 4023581 200 µM -0.125988057113897 0.452661337161709 no 1866 0.449870689142444 611 16641307
SGTC_2575 plumbagin 510 nM -0.126331972382224 0.452532507392092 no 1867 0.449734574348705 611 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2102 5377816 72.7585 µM -0.126608890666858 0.452428778150218 no 1868 0.449624979920029 600 1379702
SGTC_3329 9141233 27.5565 µM -0.128016778337963 0.451901455894683 no 1869 0.449067847549298 599 4909101 YNL103W MET4
SGTC_2568 diosmetin 100 µM -0.128322603246965 0.451786920810014 no 1870 0.448946839087723 592 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_579 4491-1009 110 µM -0.128540299050998 0.45170539357313 no 1871 0.448860704345515 601 1271041
SGTC_2646 retinol 96.75 µM -0.12915482194635 0.451475265302784 no 1872 0.44861757178984 621 445354 A vitamin A analog and teratogen.
SGTC_1893 st059353 36.1 µM -0.1292407924446 0.451443072126097 no 1873 0.448583559578282 666 3112488
SGTC_1038 k292-0204 154 µM -0.131007626913361 0.4507815206719 no 1874 0.447884637001945 589 4454212
SGTC_1259 0671-0132 43 µM -0.131401336726473 0.450634123442304 no 1875 0.447728915638972 616 X1259
SGTC_853 0419-0306 21 µM -0.131444731940273 0.450617877541838 no 1876 0.447711752317854 614 762713
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.131587292394421 0.450564507654516 no 1877 0.447655368658734 619 6708760
SGTC_660 4031-1742 102 µM -0.131754440555218 0.450501934086979 no 1878 0.447589261736396 593 6738706
SGTC_502 l-744,832 89.3 µM -0.133436045464041 0.449872477364993 no 1879 0.446924270061872 635 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_475 α-linolenic acid 10 µM -0.133597165500273 0.449812173663713 no 1880 0.446860562849666 627 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3089 9117425 49.47 µM -0.133674558139795 0.449783207705481 no 1881 0.446829962119381 605 9401657
SGTC_2566 crystal violet carbinol 226 nM -0.133924309785258 0.449689734288823 no 1882 0.446731213509559 634 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2932 9016711 44.54 µM -0.134338668978667 0.449534660110977 no 1883 0.446567388466765 632 7117328
SGTC_2126 5251174 33.877 µM -0.134606946098883 0.449434261345916 no 1884 0.446461324701453 605 790722
SGTC_1173 0443-0020 122 µM -0.13509379771018 0.449252072565385 no 1885 0.446268856967711 617 5331295
SGTC_2815 7968870 71.43 µM -0.135563206842783 0.449076421209559 no 1886 0.446083296779318 633 2977326 YHR190W ERG9
SGTC_2589 lobaric acid 100 µM -0.136398984506305 0.448763700677569 no 1887 0.445752938211398 607 73157 A novel microtubule depolymerizer.
SGTC_2643 anethole 100 µM -0.137074166568696 0.448511092975047 no 1888 0.445486085896091 626 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2182 6325192 200 µM -0.138557477715828 0.447956211181643 no 1889 0.444899923483462 587 736248
SGTC_1402 3909-7673 35.9 µM -0.138814865850521 0.447859936938975 no 1890 0.444798223236204 606 5328014
SGTC_2138 5575593 77.673 µM -0.139591031660587 0.447569636131307 no 1891 0.444491563469319 613 762213
SGTC_2336 9001819 198.65 µM -0.139638558854266 0.447551860965841 no 1892 0.444472786757538 610 2989602
SGTC_653 0203-0016 55.2 µM -0.140288018534385 0.447308973682598 no 1893 0.444216215266232 625 295302
SGTC_3016 9080866 49.47 µM -0.140386321662592 0.447272211642215 no 1894 0.444177382279635 623 17066299
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.141812636955352 0.4467388691603 no 1895 0.443614001053953 648 688798
SGTC_1047 2043-3044 82 µM -0.142262520514313 0.446570664010091 no 1896 0.443436324832549 656 669592
SGTC_918 glabranin 770.725 nM -0.142437607018191 0.446505204219822 no 1897 0.443367179548641 630 124049 Also referred to as licorice root.
SGTC_2208 7283366 200 µM -0.142872222148865 0.446342720470734 no 1898 0.443195548496169 606 898663
SGTC_943 3253-1379 105 µM -0.143177962561381 0.446228422786076 no 1899 0.443074816909293 613 668464
SGTC_2309 7664088 163.95 µM -0.143241641858778 0.446204617544198 no 1900 0.443049671723686 636 704922
SGTC_1261 0712-0010 12.7 µM -0.143863043080499 0.445972329217275 no 1901 0.442804309697801 624 2840123
SGTC_713 1488-1073 324 µM -0.144143682932943 0.445867428252191 no 1902 0.442693505444286 625 3312542
SGTC_804 1595-0054 20.9 µM -0.144483083368789 0.445740568107105 no 1903 0.442559506901818 639 761523 Stimulates phospholipase C.
SGTC_3278 9139605 49.47 µM -0.1447339118882 0.44564681769393 no 1904 0.442460481621777 646 7958859
SGTC_128 0906-2981 13.371 µM -0.144749622936649 0.445640945586836 no 1905 0.442454279133386 626 6740226
SGTC_2272 7805186 180 µM -0.145174993673724 0.445481965028562 no 1906 0.442286354455122 656 2956062 YPR165W RHO1
SGTC_2268 7933382 153.85 µM -0.145224628674851 0.4454634147223 no 1907 0.442266760595612 599 935025 YOR257W CDC31
SGTC_1769 st044406 64.4 µM -0.145310255589332 0.445431413281386 no 1908 0.442232958939224 616 670903
SGTC_907 3448-6986 75.5 µM -0.146957674665602 0.444815791008053 no 1909 0.441582714121709 627 590582
SGTC_2854 9024559 71.43 µM -0.147688679844343 0.444542665003349 no 1910 0.44129423291861 642 3163529
SGTC_541 4513-1321 94 µM -0.147895561462491 0.444465372446334 no 1911 0.441212595563025 598 747515
SGTC_3152 9099253 49.47 µM -0.149049789538055 0.444034182836674 no 1912 0.440757172675015 623 25236131
SGTC_974 1326-0144 138 µM -0.149430707546415 0.443891896281442 no 1913 0.440606891312706 638 5411856
SGTC_584 0986-0246 15.4 µM -0.149780971480107 0.443761066506151 no 1914 0.4404687112724 640 53315 YDR232W HEM1
SGTC_1269 0831-0796 3.05 µM -0.150195748915792 0.443606147724219 no 1915 0.440305089862576 606 927758
SGTC_1607 st000305 50.6 µM -0.151971757213791 0.442942908895979 no 1916 0.43960460568094 641 5457690
SGTC_168 3970-0862 530.542 µM -0.152382413211411 0.442789574751477 no 1917 0.439442663655656 608 3135186
SGTC_513 4245-1575 41.7 µM -0.152737103727293 0.442657144358598 no 1918 0.439302799750368 610 719745
SGTC_371 0195-0006 7.36 µM -0.153240731843243 0.442469116314446 no 1919 0.439104218808913 610 3928593
SGTC_765 1319-0117 244 µM -0.153633585701616 0.442322454501093 no 1920 0.438949326876931 599 3487746 YGL099W LSG1
SGTC_768 0384-0033 77.3 µM -0.153970404993047 0.442196718035241 no 1921 0.438816535341655 621 3965305 YMR134W ERG29
SGTC_975 1335-0046 28.5 µM -0.155000430153058 0.441812240249487 no 1922 0.438410489095605 640 16486740
SGTC_758 0868-0029 16 µM -0.156249244545326 0.441346168493963 no 1923 0.437918280917907 603 762687
SGTC_1252 0493-0875 34.8 µM -0.156944056259709 0.441086891968419 no 1924 0.43764446909684 617 3960963
SGTC_151 3013-0144 2.285 µM -0.16017374046624 0.439882033478622 no 1925 0.436372107187264 642 906558 YHR107C CDC12
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.162204225189737 0.439124829790665 no 1926 0.435572516321575 619 165521
SGTC_512 prima-1 270 µM -0.163666522051943 0.438579651193238 no 1927 0.434996836820611 624 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1059 3448-6867 171 µM -0.164388468052255 0.438310535676607 no 1928 0.434712670620008 618 3934407
SGTC_1796 st049173 110.4 µM -0.165693855901061 0.437824006510134 no 1929 0.434198940749831 615 94134
SGTC_1968 st069590 43.6 µM -0.16587570157801 0.437756238519038 no 1930 0.434127384949642 612 6384066
SGTC_165 k038-0023 64.381 µM -0.167177328203836 0.437271217874198 no 1931 0.433615261417321 621 46368543
SGTC_589 1227-0070 34.1 µM -0.167300814738953 0.437225208395988 no 1932 0.433566681552771 615 2841384
SGTC_173 1273-0061 2.693 µM -0.169638107004698 0.436354524462263 no 1933 0.432647375906335 637 2847414 YPL266W DIM1
SGTC_2890 9046729 58.44 µM -0.170996862873473 0.435848504589941 no 1934 0.432113116165407 631 903329
SGTC_1162 k048-0130 20.1 µM -0.171772397950868 0.435559731391381 no 1935 0.431808233100219 647 6797406
SGTC_506 n9-isopropylolomoucine 153 µM -0.171816071087709 0.435543470566576 no 1936 0.43179106525736 640 6610355
SGTC_2140 5586273 200 µM -0.172800465558797 0.435176979806917 no 1937 0.43140413554299 611 854421
SGTC_2069 5228469 200 µM -0.172940918050976 0.43512469377599 no 1938 0.43134893412586 633 2835210
SGTC_66 0109-0187 42.4 µM -0.173307763754391 0.434988134049098 no 1939 0.431204760720984 628 759417
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.174726952355344 0.434459908793426 no 1940 0.430647094315224 651 7104
SGTC_871 0574-0004 149 µM -0.175164639095792 0.434297024342573 no 1941 0.430475134314923 625 9551173
SGTC_652 0437-0092 114 µM -0.176326362845324 0.433864744789643 no 1942 0.430018775970549 618 3091274
SGTC_1221 2958-7315 257 µM -0.176496968760977 0.433801268660949 no 1943 0.429951764940213 639 4562705
SGTC_2933 9026794 32.47 µM -0.177294712883461 0.433504480364344 no 1944 0.429638451758961 646 17586027
SGTC_431 k089-0097 107 µM -0.177707215994951 0.433351029690564 no 1945 0.429476458955285 653 5499420
SGTC_1074 carmofur 3.8 µM -0.179710148661551 0.432606084329579 no 1946 0.428690062841349 631 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_396 dithiazanine 1.25 µM -0.180207698941752 0.432421068822742 no 1947 0.42849475725002 616 10578 An antihelmenthic.
SGTC_1365 1672-3266 55.4 µM -0.180830643597309 0.4321894459492 no 1948 0.428250254747281 620 6415873
SGTC_2083 5306046 65.942 µM -0.180943890794893 0.432147340951522 no 1949 0.428205808773323 631 539837
SGTC_190 3970-0790 3.722 µM -0.181275832998018 0.432023930191898 no 1950 0.428075537116488 617 2832352
SGTC_1573 oleylamine 1.06 µM -0.181801673567957 0.431828444726414 no 1951 0.427869185546612 649 5356789 An amine of the fatty acid oleic acid.
SGTC_2508 celastrol 40.54 µM -0.182527830913611 0.43155851733787 no 1952 0.427584257645996 616 122724 Celastrol is a natural product and antioxidant.
SGTC_1831 st055328 12 µM -0.184595367810314 0.430790147445078 no 1953 0.426773209728288 639 1103068
SGTC_2492 derrusnin 100 µM -0.184697565722129 0.430752173853106 no 1954 0.426733127800555 642 1715307 Part of coumarin class of compounds.
SGTC_1242 0402-0103 60.1 µM -0.185672152621344 0.430390079634505 no 1955 0.426350933774738 623 432868
SGTC_384 k007-0144 5.16 µM -0.187526569889032 0.429701258537051 no 1956 0.425623896715379 626 6824886
SGTC_1179 1021-1431 9.29 µM -0.187709339017838 0.429633380709025 no 1957 0.425552254465491 665 2840958
SGTC_1226 3909-7979 35.4 µM -0.187792610802691 0.429602455454395 no 1958 0.425519614220798 625 6615510
SGTC_825 1988-2224 89.6 µM -0.188137028178212 0.429474551233194 no 1959 0.425384617525591 635 1180859
SGTC_127 0180-0333 59.125 µM -0.189783216591526 0.428863318567136 no 1960 0.424739504047686 616 771601
SGTC_2225 6654152 15.4 µM -0.190063335790223 0.428759326754592 no 1961 0.424629750073733 655 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2318 6029776 164 µM -0.190278674200802 0.428679387607205 no 1962 0.424545381941279 659 818325
SGTC_1488 4013-0813 75.9 µM -0.190888697077384 0.428452947346255 no 1963 0.424306397884829 630 2910057
SGTC_2424 5537928 59.2 µM -0.191456431254289 0.428242225793355 no 1964 0.424084005951663 642 5382802
SGTC_3213 9129884 49.47 µM -0.192708042432693 0.427777747196085 no 1965 0.423593812283522 656 17190742
SGTC_425 3825-7017 13.1 µM -0.194683364114524 0.427044900168735 no 1966 0.422820418115432 639 3397440
SGTC_2852 9023854 51.95 µM -0.196029938581482 0.426545463343413 no 1967 0.422293366493368 645 19798528
SGTC_311 1315-0136 58 µM -0.197228098756942 0.426101171514636 no 1968 0.421824521412488 637 6759207
SGTC_2593 nobiletin 86.24 µM -0.198383211077575 0.425672931114204 no 1969 0.421372626011031 626 72344 An anti-infammatory.
SGTC_1514 1189-1591 158 µM -0.199422985181628 0.425287525560101 no 1970 0.42096594099753 690 767698 YMR146C TIF34
SGTC_998 3996-0085 177 µM -0.199495511600621 0.425260645375492 no 1971 0.420937577008006 616 715391
SGTC_2774 tamoxifen 10.92 µM -0.199876501813156 0.425119446163793 no 1972 0.420788584220874 628 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_79 0052-0007 94.094 µM -0.200431965875321 0.424913602217191 no 1973 0.420571380762991 631 2801472
SGTC_3091 9116372 49.47 µM -0.201098263751113 0.424666712471898 no 1974 0.42031086979475 638 17169793
SGTC_2347 9049783 174.81 µM -0.202533758266021 0.42413490545119 no 1975 0.419749734966727 682 6467988 YPL169C MEX67
SGTC_1939 st074455 53.6 µM -0.203154107289319 0.423905127703295 no 1976 0.419507290936309 649 1644229
SGTC_2475 5812728 15.03 µM -0.204611680972475 0.423365343235121 no 1977 0.418937764195814 635 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3049 9092223 49.47 µM -0.20658378070085 0.422635242988111 no 1978 0.418167464076528 661 8623917
SGTC_58 0957-0393 9 µM -0.206909298923929 0.422514756847307 no 1979 0.418040347086765 645 6997992
SGTC_2950 9072895 21.46 µM -0.207416361772936 0.422327088879046 no 1980 0.417842352795982 653 17332245
SGTC_3126 9127922 49.47 µM -0.207837206261686 0.422171344395299 no 1981 0.417678040247251 673 45595682
SGTC_2963 9082507 9 µM -0.209105726306752 0.421701969173502 no 1982 0.41718285228727 668 16459611
SGTC_157 1348-1695 65.819 µM -0.209175376172602 0.421676200685885 no 1983 0.417155667096836 630 5380510
SGTC_1184 1269-1718 139 µM -0.209826439041301 0.421435342006304 no 1984 0.416901568505947 628 5403821
SGTC_418 lividomycin a 100 µM -0.210667897515448 0.421124090622079 no 1985 0.416573213234222 638 72394 An antibiotic.
SGTC_356 1634-0012 32.5 µM -0.21182419486451 0.420696462312364 no 1986 0.416122096019164 682 735457
SGTC_854 0422-0053 192 µM -0.213138976623379 0.42021033612076 no 1987 0.415609282046059 635 3596728
SGTC_359 0081-0058 15.9 µM -0.213285323286472 0.420156233553964 no 1988 0.415552210255005 632 3494159
SGTC_1060 3448-7350 82 µM -0.21330095659886 0.420150454199246 no 1989 0.415546113732472 666 570178
SGTC_2073 5212005 126 µM -0.213516304218619 0.420070845805764 no 1990 0.415462136694691 648 691789
SGTC_1900 st060200 72.8 µM -0.214855459295692 0.419575868650891 no 1991 0.414940006091588 627 688945
SGTC_3129 9127257 49.47 µM -0.215573289539105 0.419310597281596 no 1992 0.414660189056309 695 837894
SGTC_676 falcarinol 140 µM -0.216011117251661 0.41914881775333 no 1993 0.414489540911441 667 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1652 st011932 78 µM -0.216109363842937 0.419112517023549 no 1994 0.414451250442657 646 1551076
SGTC_1876 myriocin 605 nM -0.217068479753611 0.418758173440354 no 1995 0.414077488909001 659 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2699 st077704 54.6 µM -0.217261234015085 0.418686968682212 no 1996 0.414002383145604 646 645852
SGTC_2174 5790901 200 µM -0.217821529519488 0.418480006779879 no 1997 0.413784084587389 649 786020
SGTC_2139 5578692 56.4705 µM -0.219243250848523 0.417954952884381 no 1998 0.413230282819049 636 650991 YMR113W FOL3
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.220316348971564 0.41755874530034 no 1999 0.412812394161836 623 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1360 1598-0022 39.8 µM -0.221054938933798 0.417286092881684 no 2000 0.412524827908373 668 761525
SGTC_582 0987-0078 156 µM -0.221329818336842 0.417184630577707 no 2001 0.412417816987155 637 1625765
SGTC_558 k064-0027 21.3 µM -0.221386965604789 0.417163537315969 no 2002 0.412395570296077 643 5088526
SGTC_1280 0880-0253 10.1 µM -0.221392730032198 0.417161409658356 no 2003 0.412393326294789 671 6836607
SGTC_3056 9094900 49.47 µM -0.221540991158065 0.417106687118795 no 2004 0.412335611545344 651 25236784
SGTC_3009 9080819 71.4286 µM -0.223733719972438 0.416297548456628 no 2005 0.411482253112845 663 17027216
SGTC_2411 st077133 39.94 µM -0.225814686966155 0.415529978882485 no 2006 0.410672776776956 702 1403142 YNL221C POP1
SGTC_655 k060-0012 42 µM -0.225883309289556 0.415504672848762 no 2007 0.410646089805726 665 5994525
SGTC_1410 3909-8106 77.9 µM -0.225981097474652 0.415468611849477 no 2008 0.410608061052056 652 1039210
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.226482728943516 0.415283638206609 no 2009 0.410412995290221 657 1273210
SGTC_3340 9146634 11.102 µM -0.227904202689963 0.414759580264896 no 2010 0.409860357711581 659 4907387
SGTC_2251 lansoprazole 556 µM -0.229111748581112 0.414314510694901 no 2011 0.409391031134912 681 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2128 5255449 168.493 µM -0.23052148569761 0.4137950579795 no 2012 0.408843284917157 638 736008
SGTC_2038 4100038 30.985 µM -0.230810345914312 0.413688638832343 no 2013 0.408731071679028 649 3596803
SGTC_1459 k035-0031 35.7 µM -0.231722517287035 0.413352626938479 no 2014 0.408376770537463 636 3877128 YMR208W ERG12
SGTC_453 enantio-paf c16 10 µM -0.232463515749484 0.413079715828234 no 2015 0.408089010649134 681 13871343 A lipid and platelet activating factor
SGTC_3249 9135183 49.47 µM -0.232563390327706 0.413042935044557 no 2016 0.408050229069022 679 4902779
SGTC_345 1362-0200 395 µM -0.232911121587315 0.412914882105486 no 2017 0.407915211071327 666 1419823
SGTC_2160 5660466 132.927 µM -0.23307833056295 0.412853310264294 no 2018 0.407850290627721 724 2859134
SGTC_3283 9109332 35.8195 µM -0.233315797647766 0.412765870762615 no 2019 0.407758096166721 650 17027281
SGTC_1886 st057356 49.9 µM -0.235866795864358 0.411826822803585 no 2020 0.406768017212832 638 24207747
SGTC_2432 5630864 12.22 µM -0.236248361187265 0.41168640805537 no 2021 0.406619977297819 674 5714970
SGTC_1091 telmisartan 47.6 µM -0.236879307675515 0.411454246700638 no 2022 0.40637521163329 677 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3007 9078383 71.4286 µM -0.23760074631937 0.411188826090732 no 2023 0.406095385805498 660 6496995
SGTC_180 1486-1293 102.781 µM -0.238069458725314 0.411016406406475 no 2024 0.405913611095421 680 4140536
SGTC_809 3998-0021 90 µM -0.23901849623102 0.410667347885037 no 2025 0.405545620222532 675 715485
SGTC_3137 9097352 49.47 µM -0.240002534063113 0.410305490852947 no 2026 0.405164146057536 661 44120435
SGTC_517 1365-0151 113 µM -0.240423772649473 0.410150613476747 no 2027 0.40500087534 670 768657
SGTC_1830 st055982 50.3 µM -0.24062241301046 0.410077583960219 no 2028 0.404923888711984 684 455313 An antimicrobial agent.
SGTC_2823 7987624 58.44 µM -0.241760302287479 0.409659302650944 no 2029 0.404482950351154 700 2239440
SGTC_1411 3909-8223 150 µM -0.242266845601297 0.409473133390266 no 2030 0.404286701008386 665 X1411
SGTC_2894 9048625 32.47 µM -0.242806937717274 0.409274656463749 no 2031 0.404077480430167 649 4092861
SGTC_2172 5754775 163.918 µM -0.244282978605177 0.408732349129509 no 2032 0.403505832660342 647 2263357
SGTC_1277 0873-0036 22 µM -0.247553105584645 0.407531506172753 no 2033 0.402240098874009 654 5965735
SGTC_1066 ketoconazole 628 nM -0.249494498996869 0.406819005498762 no 2034 0.401489147780918 682 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2243 6634756 200 µM -0.250130145841769 0.406585786949287 no 2035 0.401243351888333 639 885676
SGTC_1912 st060209 90.8 µM -0.250651983140308 0.40639434983201 no 2036 0.401041593786476 691 688787
SGTC_1827 berberine 7.24 µM -0.25238175464485 0.40575993972636 no 2037 0.400373000733979 676 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_344 k064-0035 6.43 µM -0.252407016343969 0.405750676587769 no 2038 0.400363238713613 677 5088750
SGTC_1556 plumbagin 1.48 µM -0.253723968827219 0.405267840340244 no 2039 0.399854407707964 658 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1680 diphenhydramine 100 µM -0.255514742463177 0.404611517726232 no 2040 0.399162779293536 657 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2325 6158266 200 µM -0.256181806744408 0.404367105634703 no 2041 0.398905228052508 644 3623240
SGTC_775 4577-0580 57.3 µM -0.259466540661565 0.403164126465559 no 2042 0.397637647452568 704 2006902
SGTC_3103 9120822 49.47 µM -0.260117811785308 0.402925717687825 no 2043 0.397386449447957 668 17141819
SGTC_1160 4092-0570 10.5 µM -0.260568792781134 0.402760649629599 no 2044 0.397212529114247 650 4994975
SGTC_737 1950-0117 57.9 µM -0.260738000395635 0.402698720730514 no 2045 0.39714727965112 662 5393513
SGTC_266 formosanin C 406 nM -0.261833637629194 0.402297783694965 no 2046 0.396724852207056 672 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_527 4476-4215 268 µM -0.262350123770764 0.402108816584256 no 2047 0.396525760842794 642 4418754
SGTC_3236 9132701 49.47 µM -0.262367215700286 0.402102563540051 no 2048 0.396519172829532 686 24282524
SGTC_2896 9052656 71.43 µM -0.262382377196313 0.402097016761596 no 2049 0.396513328918572 680 6469436
SGTC_1558 st069300 45.6 µM -0.262396532755244 0.402091838019384 no 2050 0.396507872761232 671 24208000
SGTC_808 0711-0032 135 µM -0.26436555857417 0.401371647392301 no 2051 0.395749123992122 683 4252555
SGTC_619 1652-1634 108 µM -0.264883788011888 0.401182155436485 no 2052 0.395549493838706 662 5400454
SGTC_2682 pyrogallin 40.03 µM -0.265314317442783 0.401024748891287 no 2053 0.395383667947178 675 822798 An ATP competetive kinase inhibitor.
SGTC_2365 9042475 200 µM -0.266015810175828 0.400768309449622 no 2054 0.395113516416853 658 6464479
SGTC_1656 st012921 11 µM -0.266114460793539 0.400732249909328 no 2055 0.395075529164755 660 6732821
SGTC_1626 st003712 1.76 µM -0.26720077446399 0.400335228102587 no 2056 0.394657289943541 701 24207035
SGTC_319 1348-1596 45.5 µM -0.267499448144021 0.400226088006204 no 2057 0.394542319506211 698 5380505
SGTC_298 1391-0729 10 µM -0.268259642338962 0.399948336170336 no 2058 0.394249734384315 656 3237558
SGTC_896 0964-0007 44.5 µM -0.27007787803727 0.399284213685308 no 2059 0.393550170343867 656 6756758
SGTC_3346 9158254 43.5805 µM -0.270633438185068 0.399081349733378 no 2060 0.393336487635409 674 17639500
SGTC_212 3807-4682 38.772 µM -0.272426282111935 0.398426875164957 no 2061 0.392647133216898 658 3125501 YBL034C STU1
SGTC_869 0564-0080 44.1 µM -0.273828946229314 0.397915034083309 no 2062 0.392108038818143 670 6843321
SGTC_3047 9092122 49.47 µM -0.274896993856011 0.397525414436197 no 2063 0.391697688382387 695 17173831
SGTC_2034 5197015 53.07 µM -0.275003215477847 0.397486670780806 no 2064 0.391656883963979 716 780676
SGTC_2958 9077254 16.72 µM -0.275603184383027 0.397267854968459 no 2065 0.391426431789213 668 16457351
SGTC_562 3772-2733 112 µM -0.275963206871561 0.397136565991028 no 2066 0.391288162967468 686 2876874 YIL048W NEO1
SGTC_1756 st041558 35.5 µM -0.277603317132753 0.396538616615303 no 2067 0.390658442746384 711 3955792
SGTC_1797 st048695 56.8 µM -0.279031635311565 0.396018080230056 no 2068 0.390110273538956 697 592262 YIL048W NEO1
SGTC_2177 5811945 192 µM -0.279084374193568 0.395998863610717 no 2069 0.390090037244163 653 5343475
SGTC_3017 9080681 49.47 µM -0.279354798042315 0.395900332460451 no 2070 0.389986278315619 685 16451914
SGTC_1733 st037357 54.9 µM -0.279622055649225 0.395802961491201 no 2071 0.389883741943371 708 1272339 YGL099W LSG1
SGTC_415 dibenzyl ketone 100 µM -0.280451281296953 0.395500888002241 no 2072 0.389565649041833 686 7593
SGTC_3291 9121177 71.43 µM -0.280903687273222 0.395336110276581 no 2073 0.389392136221659 685 17015612
SGTC_1155 4088-0394 48.2 µM -0.280980926016005 0.395307979837542 no 2074 0.389362514783616 673 2326248
SGTC_1972 st070201 17.4 µM -0.282672383511338 0.394692086099201 no 2075 0.388713993978658 658 2829099
SGTC_1958 st076513 41.9 µM -0.282701490318982 0.394681490022733 no 2076 0.388702836861537 699 732122 YGL099W LSG1
SGTC_1218 1348-1416 30.7 µM -0.283264180227867 0.394476663047804 no 2077 0.388487166636515 666 6787668
SGTC_837 0091-0265 12.5 µM -0.283973467453901 0.394218514173135 no 2078 0.388215356936895 670 759367
SGTC_93 0109-0045 59.227 µM -0.283982382189169 0.394215269903024 no 2079 0.38821194102224 669 88733
SGTC_2544 sphondin 68.51 µM -0.284178153946346 0.394144026064304 no 2080 0.388136928118962 646 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1624 st003710 6.25 µM -0.284765176712317 0.393930422235849 no 2081 0.387912026514718 713 24207033
SGTC_2737 bleomycin 30.5 nM -0.286057410391184 0.393460321189764 no 2082 0.387417075333637 678 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_514 4466-0038 2.65 nM -0.290270611488039 0.391928684594127 no 2083 0.385804610026822 692 5722064
SGTC_90 0870-0863 4.608 µM -0.290429820072154 0.391870839721113 no 2084 0.385743716612223 692 1738164
SGTC_545 4218-0007 221 µM -0.291557142241636 0.391461320909959 no 2085 0.385312623910083 700 2840508
SGTC_3004 9076122 71.4286 µM -0.292447681611083 0.391137902453513 no 2086 0.384972178072875 709 44782551
SGTC_729 4092-0585 94.1 µM -0.292495109508024 0.39112068010531 no 2087 0.384954049264304 665 2169061
SGTC_764 1951-2361 146 µM -0.292600906454374 0.391082263150786 no 2088 0.384913610414391 683 5438930
SGTC_368 fentichlor 4.58 µM -0.293998950247338 0.39057470586375 no 2089 0.38437935276285 711 7329 A pesticide.
SGTC_842 0271-0008 11.1 µM -0.295288802410584 0.390106592648034 no 2090 0.383886634869796 690 1221709
SGTC_3132 9126706 49.47 µM -0.295614905547646 0.389988268483547 no 2091 0.383762094581239 719 850858
SGTC_1507 4075-3230 155 µM -0.296933296894635 0.389510003730196 no 2092 0.383258717363415 695 659771
SGTC_2161 5662504 8.5105 µM -0.297971123087246 0.389133635517716 no 2093 0.382862601749696 646 2859334
SGTC_2193 5925765 200 µM -0.298845770991182 0.388816524736884 no 2094 0.382528862817569 694 877370
SGTC_322 k048-0136 19.3 µM -0.298876287956449 0.388805461896469 no 2095 0.382517220048849 667 6823282
SGTC_858 0438-0351 2.77 µM -0.300630965874057 0.388169517736385 no 2096 0.381847957904838 686 2799119
SGTC_618 k072-0232 33.2 µM -0.301016896232038 0.388029685976783 no 2097 0.38170080519708 714 5872756 YGL099W LSG1
SGTC_650 1328-0195 38 µM -0.301916080845887 0.387703946316976 no 2098 0.381358018361839 702 2780821
SGTC_2975 9084847 53.72 µM -0.302309251859804 0.387561540545882 no 2099 0.381208163071632 662 27211724
SGTC_3250 9135583 49.47 µM -0.302421044513014 0.387521052226814 no 2100 0.381165557076687 661 7699353
SGTC_1515 3460-0031 42.1 µM -0.303056305096291 0.387291001014447 no 2101 0.380923476318746 671 2876596
SGTC_3343 9148379 18.9835 µM -0.303929160874184 0.386974972408646 no 2102 0.38059093043134 693 1955036
SGTC_991 3996-0057 64.7 µM -0.304430108329181 0.386793631792694 no 2103 0.380400116256553 666 715343
SGTC_2066 5222451 176 µM -0.307270473266141 0.385765901471958 no 2104 0.37931875409756 696 2281147
SGTC_2456 5770359 74.46 µM -0.308632277672625 0.385273443023593 no 2105 0.378800632353987 713 3118787
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.309247434900759 0.38505104922195 no 2106 0.378566656616094 702 23847180
SGTC_189 3970-0742 2.116 µM -0.31016511394481 0.384719356955887 no 2107 0.37821769911161 700 2891807
SGTC_920 mycophenolic acid 780.421 nM -0.311598083977813 0.384201583146282 no 2108 0.377672995278886 676 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1390 3413-2614 145 µM -0.312722946813228 0.383795282116543 no 2109 0.377245580163288 712 3421432
SGTC_2119 5528445 120.635 µM -0.315317445800436 0.382858635429567 no 2110 0.37626032014866 689 791935
SGTC_2606 farnesol 9.78 µM -0.317825961797694 0.381953680507612 no 2111 0.375308478171934 674 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_794 k038-0031 316 µM -0.320425366011057 0.381016617442445 no 2112 0.374322949550923 666 6624242
SGTC_3045 9092950 49.47 µM -0.322422867652729 0.380297008621053 no 2113 0.37356618128436 708 44120432
SGTC_1930 st074634 34.3 µM -0.323013137858244 0.380084440315565 no 2114 0.373342646193761 712 684253 YOR116C RPO31
SGTC_20 0481-0013 4.944 µM -0.324148452870196 0.379675692163428 no 2115 0.372912822724356 676 182045
SGTC_265 mycophenolic acid 32.932 µM -0.324175070996667 0.379666110434142 no 2116 0.372902747156463 708 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1952 st077036 64.1 µM -0.324837177451457 0.379427795708297 no 2117 0.372652152758185 702 2937007
SGTC_3153 9100258 49.47 µM -0.325806612615757 0.379078945533809 no 2118 0.372285337674783 715 25236848
SGTC_890 0929-0006 47.2 µM -0.326158009046317 0.378952520213902 no 2119 0.372152404807085 688 1378169
SGTC_3320 9137005 35.139 µM -0.326234491981763 0.378925004917948 no 2120 0.372123473418396 707 4908713
SGTC_1631 benzylvanillin 81.9 µM -0.328714092645872 0.378033283554468 no 2121 0.371185900686356 695 75506
SGTC_2022 5136654 200 µM -0.330020920124649 0.37756357937463 no 2122 0.370692077449383 726 1713771
SGTC_120 rhodamine 6G 52.259 µM -0.336654919552186 0.37518197095878 no 2123 0.368188525241232 720 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3310 9130229 44.1445 µM -0.336943605627222 0.375078439757366 no 2124 0.368079706405253 716 7761258
SGTC_3307 9126885 69.2785 µM -0.337564447619804 0.374855818306156 no 2125 0.367845718852028 697 24824909
SGTC_2353 9059630 146.67 µM -0.337755652728591 0.374787264394223 no 2126 0.367773665918948 689 4779114
SGTC_2970 9090938 41.86 µM -0.33786527030475 0.374747964332848 no 2127 0.367732360188568 679 17217104
SGTC_1256 0570-0116 285 µM -0.338006739110345 0.374697246900702 no 2128 0.367679054645034 710 410638
SGTC_42 0133-0086 60.653 µM -0.338474642813373 0.374529516004507 no 2129 0.367502766368808 722 162923 Model of phenazepam hydroxylation.
SGTC_2266 7929956 200 µM -0.339187664047893 0.374273962724328 no 2130 0.367234180848484 692 2967153
SGTC_1061 3448-9325 110 µM -0.339200698448225 0.374269291590706 no 2131 0.367229271569118 724 723482
SGTC_211 3455-0679 143.504 µM -0.340802126935147 0.373695528843829 no 2132 0.366626274578389 689 748649
SGTC_1 0258-0098 57.368 µM -0.340823559697472 0.373687851769008 no 2133 0.366618206579594 668 6790032 YDR047W HEM12
SGTC_2645 abamectin 100 µM -0.342617020424073 0.373045623746381 no 2134 0.365943297915537 689 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2916 7875993 68.79 µM -0.343267068723776 0.372812932143136 no 2135 0.365698776352929 742 1299250
SGTC_1085 doxorubicin 7.67 µM -0.343499741527176 0.372729655746205 no 2136 0.365611267621797 714 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2226 7298446 200 µM -0.343569867467887 0.372704557994296 no 2137 0.36558489447926 717 3283010
SGTC_2563 tomatine 8.54 µM -0.348605684283457 0.370903681190996 no 2138 0.363692679853152 769 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1100 amiodarone 5.07 µM -0.349133260843838 0.370715175369417 no 2139 0.363494633621794 683 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1399 3562-5772 25 µM -0.350326286021186 0.37028901581469 no 2140 0.363046920137587 681 23847490
SGTC_1837 st055472 66.5 µM -0.351009492129892 0.370045039952929 no 2141 0.362790613623408 705 676091
SGTC_861 0443-0273 110 µM -0.351193419341124 0.369979367677619 no 2142 0.36272162335634 703 6149169
SGTC_2438 5259590 200 µM -0.351559363287366 0.369848716550463 no 2143 0.36258437268839 707 1201127
SGTC_1395 3486-0190 4.35 µM -0.35384186449993 0.369034146207106 no 2144 0.361728698605874 731 6748079
SGTC_1581 himbacine 57.9 µM -0.354274973382662 0.36887964620085 no 2145 0.361566410703088 730 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1257 0669-0121 16 µM -0.354864020450129 0.368669553424392 no 2146 0.361345732006652 682 4307855
SGTC_2196 6573537 42.6665 µM -0.355156502127519 0.368565249873622 no 2147 0.361236174745642 733 2903087
SGTC_3027 9089541 49.47 µM -0.355746496280251 0.368354878184569 no 2148 0.361015210435433 701 9943819
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.355870096579106 0.368310811552329 no 2149 0.36096892558712 705 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_349 k015-0014 24 µM -0.358791111098087 0.367269901398051 no 2150 0.359875681426055 689 2196908
SGTC_3106 9121286 49.47 µM -0.359086062326731 0.367164848911475 no 2151 0.359765353947023 684 15943471
SGTC_563 tetrahydrosecaminediol 614 µM -0.359625629560825 0.366972697523458 no 2152 0.359563557289568 709 334274 A psychoactive constituent of the cannabis plant.
SGTC_1917 st066507 28.5 µM -0.359792320164447 0.366913342182979 no 2153 0.359501223377437 692 3156428
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.360013144437777 0.366834715775775 no 2154 0.359418651948951 737 6710655
SGTC_2190 6049624 200 µM -0.360367116072497 0.36670869274571 no 2155 0.359286307262614 717 2265554
SGTC_1525 8-methoxypsoralen 92.5 µM -0.360502735946333 0.366660412379266 no 2156 0.359235605497485 756 4114 Related to psoralen; DNA damaging agent.
SGTC_1430 4049-0248 69.1 µM -0.362327850145213 0.366010881390224 no 2157 0.358553524320979 722 22774488
SGTC_2327 6189656 200 µM -0.3624051538483 0.365983378612164 no 2158 0.358524644342017 732 5349088
SGTC_2870 9038528 12.99 µM -0.363577746481654 0.36556628318219 no 2159 0.358086673418811 716 6463316
SGTC_216 k038-0035 28.382 µM -0.366050071218949 0.364687389593598 no 2160 0.357163856529725 690 4444231 YPR107C YTH1
SGTC_2974 9094440 9.66 µM -0.367536911295463 0.364159170590891 no 2161 0.356609282088311 689 25236134
SGTC_819 1013-0258 27.7 µM -0.368812036173588 0.363706371541305 no 2162 0.356133916302486 726 5753198
SGTC_282 k297-0036 65.7 µM -0.369165629068188 0.363580843766278 no 2163 0.356002136638048 718 5061378
SGTC_2481 5478948 45.16 µM -0.37010440330574 0.363247643896037 no 2164 0.355652350674674 695 77792
SGTC_592 k241-0073 46.5 µM -0.370532151943986 0.363095857033366 no 2165 0.355493012412724 735 4230158
SGTC_3231 9132313 49.47 µM -0.370812878265159 0.362996252812627 no 2166 0.355388454338005 726 4905967
SGTC_75 0159-0059 199.013 µM -0.370990804293581 0.362933127856709 no 2167 0.355322190436892 751 5377270
SGTC_1468 k284-1086 134 µM -0.371231406589721 0.362847772410965 no 2168 0.355232591353914 709 15996457
SGTC_110 0850-0284 111.64 µM -0.371359594808179 0.362802299473368 no 2169 0.355184857974446 691 3906265
SGTC_1357 1503-1303 39.5 µM -0.372942634232789 0.362240898525788 no 2170 0.354595569923241 691 292895
SGTC_386 1509-0011 3.07 µM -0.375261553202718 0.361419064003607 no 2171 0.353732978207225 724 3107280
SGTC_2141 5621638 7.665 µM -0.376428693222912 0.36100566623391 no 2172 0.353299108945762 730 2856238
SGTC_10 0279-0212 42.575 µM -0.378042329942958 0.360434387965267 no 2173 0.35269957427768 707 39851 YBR002C RER2
SGTC_2834 9001755 58.44 µM -0.379765238542924 0.359824767765915 no 2174 0.352059844087193 728 2989575
SGTC_1427 4048-4900 550 nM -0.382080335991451 0.359006173654842 no 2175 0.351200888471438 728 24132586
SGTC_2296 7971656 126.45 µM -0.382177112444383 0.358971968581652 no 2176 0.351164998640472 702 666570
SGTC_257 daunorubicin 18.5 µM -0.382447626407777 0.358876362996446 no 2177 0.351064684786786 715 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.383550035148083 0.358486838973474 no 2178 0.350655989360322 724 91467 include heat shock
SGTC_1196 1588-0294 184 µM -0.384286536199927 0.358226686401037 no 2179 0.350383042947319 741 6144269
SGTC_1649 st011737 51.3 µM -0.384548132305276 0.358134299241267 no 2180 0.350286114325257 706 1761035
SGTC_3208 9114115 49.47 µM -0.385020127377293 0.357967627088023 no 2181 0.3501112517134 741 650895
SGTC_1602 st001878 87.6 µM -0.386538463061548 0.357431652100803 no 2182 0.349548961212362 754 595405 YLR310C CDC25
SGTC_427 1354-0053 47.3 µM -0.388403194794145 0.35677378341656 no 2183 0.348858840173637 739 6813657
SGTC_3178 9107506 49.47 µM -0.389287563966248 0.356461930806737 no 2184 0.348531717363826 714 8897194
SGTC_402 epigallocatechin gallate 10 µM -0.38956336006369 0.356364697222892 no 2185 0.348429725077703 725 65064 An antioxidant.
SGTC_150 3970-0969 77.2 µM -0.389713985448245 0.35631159727338 no 2186 0.348374026858476 725 6615640
SGTC_2030 5175110 200 µM -0.39029482231791 0.356106861011043 no 2187 0.348159275759208 750 2831986
SGTC_978 1416-0512 87.4 µM -0.390527913718679 0.356024711457191 no 2188 0.348073109247979 733 6814003
SGTC_114 0364-0001 490.298 µM -0.390831185350769 0.355917837943007 no 2189 0.347961011068724 710 4003655
SGTC_491 tetrandrine 80.3 µM -0.391291012490098 0.355755815561939 no 2190 0.347791070683129 729 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_264 promethazine 12.5 mM -0.393145653946903 0.355102588145508 no 2191 0.347105953148678 732 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_731 3966-0296 387 µM -0.393349652792203 0.355030763203889 no 2192 0.347030624995853 709 660956
SGTC_3127 9126946 49.47 µM -0.396080734121916 0.35406968734078 no 2193 0.346022735249849 735 27243249
SGTC_1929 genistein trimethyl ether 50.5 µM -0.397617931889463 0.35352915089121 no 2194 0.345455920180773 689 136420
SGTC_2442 5158906 48.48 µM -0.398546718352453 0.353202697709006 no 2195 0.345113614026927 695 1893835
SGTC_284 0988-0104 32.6 µM -0.39914333719064 0.352993052940218 no 2196 0.344893795742816 718 4666532
SGTC_2541 muurolladie-3-one 83.07 µM -0.400665624052522 0.352458341719399 no 2197 0.344333161574479 739 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_404 fumagillin 50 µM -0.401647807486347 0.352113499261751 no 2198 0.343971620316576 719 12015870 A methionine aminopeptidase binder.
SGTC_3264 9137442 49.47 µM -0.401840922232383 0.352045711389451 no 2199 0.343900551635439 728 17015726
SGTC_1157 4092-0394 27.6 µM -0.402031711601113 0.351978744396951 no 2200 0.343830344138305 710 3659885
SGTC_385 1494-0393 12.4 µM -0.403764500881931 0.351370746471512 no 2201 0.343192951654362 729 3090647
SGTC_552 k242-0005 476 µM -0.404045432247669 0.351272209558608 no 2202 0.343089655283602 758 4088318
SGTC_979 1426-2828 121 µM -0.406168578962808 0.35052783773731 no 2203 0.342309369662484 724 747872
SGTC_442 cape 100 µM -0.406705491064623 0.350339687973994 no 2204 0.342112153515042 721 5281787
SGTC_11 0438-0307 1.3 µM -0.406999273347929 0.350236753576703 no 2205 0.342004260946818 724 4011476
SGTC_898 1000-0849 28.3 µM -0.407056518564797 0.350216697480442 no 2206 0.341983238942718 729 6751807
SGTC_2458 5808907 16.39 µM -0.407533139421417 0.350049727632554 no 2207 0.341808229795039 744 2731747
SGTC_2991 9074669 71.4286 µM -0.407948276575047 0.349904320376202 no 2208 0.34165582437996 755 17333109
SGTC_1177 0983-0204 23.6 µM -0.409531494747315 0.349349979540457 no 2209 0.341074829406578 719 766818
SGTC_997 3996-0078 137 µM -0.409544034130258 0.349345590338249 no 2210 0.341070229319637 722 735687
SGTC_3054 9094397 49.47 µM -0.409728000723765 0.349281198211653 no 2211 0.341002743680864 747 2598354
SGTC_1729 st035615 45.989 µM -0.411435093191746 0.34868388752462 no 2212 0.340376762909664 705 17385451
SGTC_600 1495-0418 41.6 µM -0.411780967098295 0.348562912067119 no 2213 0.340249986478058 721 5377768
SGTC_1568 digitonin 820 nM -0.413776341445943 0.347865295957043 no 2214 0.339518955983496 760 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2837 9008476 45.46 µM -0.415632513061402 0.347216809423565 no 2215 0.338839465763034 759 2992805
SGTC_152 4469-0003 551.229 µM -0.416203946690795 0.347017258845673 no 2216 0.338630386001976 728 697280
SGTC_535 2293-4129 48.2 µM -0.416836904456856 0.346796272911845 no 2217 0.338398853439987 761 396118 YIL048W NEO1
SGTC_2211 7117706 200 µM -0.417650673562313 0.346512236489191 no 2218 0.33810127081252 731 822771
SGTC_279 1273-0055 2.93 µM -0.418969893334988 0.34605196188055 no 2219 0.337619067700334 735 2847562
SGTC_2337 9009472 200 µM -0.419691668985655 0.345800231171709 no 2220 0.337355355949339 744 5742383
SGTC_815 1582-0027 36.9 µM -0.420562067155046 0.345496756653465 no 2221 0.33703744893856 710 3128206
SGTC_2269 7935389 174.42 µM -0.421088226889426 0.345313353033135 no 2222 0.336845329087936 689 97605
SGTC_2257 7960413 200 µM -0.421943755788324 0.345015218676747 no 2223 0.336533035588443 717 2974689 YIL048W NEO1
SGTC_2663 amphotericin b 100 µM -0.422407988763385 0.344853483205842 no 2224 0.336363623904307 724 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_218 alverine citrate 93.75 µM -0.422506507689345 0.344819163557002 no 2225 0.336327675845898 736 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2651 TUB2.036 5 µM -0.425624828009047 0.343733539415921 no 2226 0.335190622892091 724 15992207 YFL037W TUB2
SGTC_2611 pyromycin 23.93 µM -0.426365809412006 0.343475760241752 no 2227 0.334920655557131 702 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2088 5278280 127.392 µM -0.428423192719074 0.342760401437367 no 2228 0.334171521081274 739 791502
SGTC_338 4055-0136 114 µM -0.42872466283693 0.342655626575838 no 2229 0.334061805152741 717 2900563
SGTC_3044 9093193 49.47 µM -0.429830093345791 0.342271541767515 no 2230 0.333659620213598 758 25236277
SGTC_2724 maprotiline 69.64 µM -0.430196317490442 0.342144332149442 no 2231 0.333526420268378 745 4011 A tricyclic antidepressant.
SGTC_2297 7971671 152.32 µM -0.430511458318538 0.342034880891631 no 2232 0.333411816711486 755 909016
SGTC_1116 jasmonic acid 1.58368 µM -0.430609358406631 0.342000882007785 no 2233 0.333376217703098 759 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3 0833-0587 95.581 µM -0.431305776123087 0.341759066042402 no 2234 0.333123025502726 721 5382644
SGTC_1054 3429-0080 167 µM -0.433994270814872 0.340826154293231 no 2235 0.332146300713787 769 1162877
SGTC_718 1130-0073 349 µM -0.43498131316733 0.340483892875806 no 2236 0.331787995719887 746 6740020
SGTC_2235 salicylic acid 500 µM -0.435998886529809 0.340131182172783 no 2237 0.331418768718895 725 338 A COX inhibitor and kinase inhibitor.
SGTC_2520 obtusaquinone 4.71 µM -0.438809994405762 0.339157525164707 no 2238 0.330399608935763 729 5967872
SGTC_337 1315-0038 354 µM -0.438830126995593 0.339150555891678 no 2239 0.330392314441664 745 1626437
SGTC_559 1550-0661 158 µM -0.440258343829666 0.338656292446351 no 2240 0.329875003666331 726 5830875
SGTC_658 3253-0951 102 µM -0.440828143247185 0.338459179242317 no 2241 0.329668708769942 735 1184878
SGTC_2036 5160441 105 µM -0.441475585866814 0.338235260294441 no 2242 0.329434366171566 738 134534 YIL048W NEO1
SGTC_203 k066-0004 30.888 µM -0.441935010150811 0.33807640244651 no 2243 0.329268117643846 738 6795412
SGTC_2709 st078560 56 µM -0.442199747464912 0.337984875752015 no 2244 0.329172334401385 760 17250903
SGTC_700 3453-2283 142 µM -0.443690870501677 0.337469534079523 no 2245 0.328633048451262 722 565664
SGTC_2761 levamisole 97.89 µM -0.444958901787105 0.337031534013851 no 2246 0.328174727402421 759 26879 An alkaline phosphatase inhibitor.
SGTC_2249 haloperidol 116.36 µM -0.445324653395726 0.336905238058685 no 2247 0.328042577051135 744 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1954 st077032 68.9 µM -0.447178179580624 0.336265488649391 no 2248 0.327373207474821 773 698907
SGTC_2567 aureobasidin a 60 nM -0.44862021150248 0.335768095171769 no 2249 0.326852825552672 711 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_788 1182-0090 188 µM -0.450655961529703 0.335066402884144 no 2250 0.326118763387792 718 5715185
SGTC_2799 7812892 81.82 µM -0.45078529233737 0.335021843916852 no 2251 0.326072151274609 763 20205235
SGTC_106 0092-0003 11.579 µM -0.450925856966913 0.334973417139998 no 2252 0.326021493461721 740 1072148
SGTC_670 4204-0025 119 µM -0.451559473695658 0.334755160047904 no 2253 0.325793185431978 741 719039
SGTC_921 1561-0023 372 µM -0.4517593191954 0.33468633237676 no 2254 0.325721189621681 751 24050882
SGTC_2108 5365811 200 µM -0.452840027123526 0.334314228080634 no 2255 0.325331969314645 712 780283
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.453998102908369 0.33391566548497 no 2256 0.324915096114682 783 6728940
SGTC_2184 6075246 200 µM -0.455318319220877 0.333461529160634 no 2257 0.324440124406753 744 2267320
SGTC_3235 9132602 49.47 µM -0.457164891250681 0.33282674303359 no 2258 0.323776265660379 745 4912240
SGTC_293 4049-0273 38.5 µM -0.45738182196809 0.332752201327396 no 2259 0.323698313911446 734 1380311
SGTC_1199 1638-0010 4.46 µM -0.458194034028629 0.332473167851823 no 2260 0.323406522846273 739 3111136
SGTC_1251 0490-5699 265 µM -0.459132387499795 0.332150914354276 no 2261 0.323069550057934 764 3883818
SGTC_1118 chelidonine 707.474 nM -0.459304402356375 0.332091853702936 no 2262 0.323007793415022 758 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_32 0928-0142 34.1 µM -0.460126593391289 0.331809615149377 no 2263 0.322712678434254 752 2244242
SGTC_1026 k007-1105 30.6 µM -0.460244375775795 0.3317691910796 no 2264 0.322670411087273 730 7066794
SGTC_3308 9128332 17.569 µM -0.462132746880554 0.331121351311045 no 2265 0.321993064022662 745 17332805 YDL196W YDL196W
SGTC_1180 1193-0155 285 µM -0.462378182508839 0.331037187250722 no 2266 0.321905071124037 768 2921347
SGTC_767 0929-0023 86 µM -0.462482496309192 0.33100141885562 no 2267 0.321867675854094 735 1204563
SGTC_522 1273-0010 11.6 µM -0.463110534707111 0.330786101955745 no 2268 0.321642569617304 753 5705015
SGTC_142 0335-0849 62.6745 µM -0.464548137924453 0.330293444369607 no 2269 0.321127539620053 724 3889043 YPR107C YTH1
SGTC_507 nimesulide 162 µM -0.465626593786439 0.329924057290629 no 2270 0.320741401998093 750 4495 A COX2 inhibitor.
SGTC_1125 tnp00248 1.32998 µM -0.466731826042172 0.329545670894237 no 2271 0.320345878310919 731 24207736
SGTC_3303 9125618 40.5795 µM -0.467104571448656 0.329418097404394 no 2272 0.320212531839349 752 22695467
SGTC_111 0083-0039 52.457 µM -0.467550995236361 0.329265333345103 no 2273 0.320052858111981 752 759313
SGTC_1103 duloxetine 36.1 µM -0.467713957855137 0.329209575425042 no 2274 0.319994579087586 748 60835 A selective serotonin reuptake inhibitor.
SGTC_717 1532-0246 73.2 µM -0.468515865495894 0.328935256803886 no 2275 0.319707863970127 750 9561992
SGTC_3114 9122766 49.47 µM -0.468988997353458 0.328773449841876 no 2276 0.31953875028923 724 17176985
SGTC_3351 9150312 21.596 µM -0.469579674033849 0.328571488619541 no 2277 0.319327674690483 752 4904905
SGTC_12 0849-0099 9.267 µM -0.469592073853597 0.32856724947143 no 2278 0.319323244298977 767 6071388
SGTC_2648 atorvastatin 78.68 µM -0.471529311693403 0.327905233868601 no 2279 0.318631396418298 765 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3181 9108277 49.47 µM -0.473079892585834 0.327375740442643 no 2280 0.318078090813633 768 17097298
SGTC_1813 st051246 8.6015 µM -0.475134431573594 0.326674689822146 no 2281 0.31734557912731 749 5291959
SGTC_2148 5546263 113.568 µM -0.477175279037448 0.325978916382647 no 2282 0.316618656507994 732 792097
SGTC_696 1560-0013 611 µM -0.477262878672502 0.325949065119434 no 2283 0.316587470508067 742 1650269
SGTC_919 tnp00227 403.569 nM -0.47788047400683 0.325738639277857 no 2284 0.316367639843015 766 1269246 A methoxyflavone. YNL221C POP1
SGTC_3253 9135987 49.47 µM -0.478636729436306 0.325481045051245 no 2285 0.316098542013455 751 4182430
SGTC_1498 4478-3555 97.6 µM -0.480757954531136 0.324758962578216 no 2286 0.315344268065531 751 3437919
SGTC_1310 1188-0297 994 nM -0.482332718987207 0.324223325196541 no 2287 0.314784803932598 754 1588352
SGTC_2002 4023503 131 µM -0.484897017691304 0.323351887930991 no 2288 0.313874699005867 797 4736863 YCR052W RSC6
SGTC_895 0964-0006 13.7 µM -0.485073129894288 0.323292074400403 no 2289 0.313812235810211 754 6738897
SGTC_501 nsc-95397 161 µM -0.485175136701212 0.323257431602779 no 2290 0.313776058638663 761 262093
SGTC_3117 9124945 49.47 µM -0.486969821541166 0.322648184908439 no 2291 0.313139858723669 751 17592065
SGTC_2549 cedrol 20.94 µM -0.488847702787802 0.322011204679698 no 2292 0.312474761455052 761 6708665 A sedative which affects the nervous system.
SGTC_3344 9148862 3.898 µM -0.489824208806805 0.321680178711555 no 2293 0.312129149194681 782 4905352
SGTC_2359 9039622 200 µM -0.495864612466048 0.31963569441222 no 2294 0.309994967376368 762 6463596
SGTC_872 0588-0139 234 µM -0.497389719387347 0.319120356586662 no 2295 0.309457126944178 724 2047100
SGTC_987 1497-1013 404 µM -0.498310902496818 0.318809255444644 no 2296 0.309132462293166 774 1676435
SGTC_1590 st077108 57.8 µM -0.499952874595732 0.318255046695008 no 2297 0.308554130142302 762 5489485
SGTC_136 0097-0015 404.482 µM -0.500204463295702 0.31817016478602 no 2298 0.308465557968894 757 4861337
SGTC_1388 3346-4487 254 µM -0.501045156286833 0.317886598012328 no 2299 0.308169671631349 770 3345614
SGTC_1735 st034310 56.75 µM -0.502765837946268 0.317306542981012 no 2300 0.307564457328188 767 871153
SGTC_2372 9071633 200 µM -0.502962304158277 0.317240341207513 no 2301 0.30749538765192 749 21321366
SGTC_1209 2323-2347 50.3 µM -0.50313781360742 0.317181206025136 no 2302 0.307433691308352 742 5412760
SGTC_1312 1218-2183 165 µM -0.503276825466683 0.317134371451255 no 2303 0.307384828726273 778 6744073
SGTC_1147 3809-1045 12.3 µM -0.503931682213948 0.316913782655258 no 2304 0.307154692979895 743 325925
SGTC_3128 9127691 49.47 µM -0.504045526084038 0.316875440931978 no 2305 0.307114692671702 773 41316314
SGTC_577 r071-0003 38.6 µM -0.504716781234551 0.316649407453403 no 2306 0.306878886397117 759 4568517 YMR134W ERG29
SGTC_1845 st056753 3.01 µM -0.504972685885122 0.31656325403647 no 2307 0.306789010277033 739 5375839
SGTC_1143 3454-2408 5.08 µM -0.505665983461657 0.316329896976004 no 2308 0.306545576012001 763 X1143
SGTC_1444 4112-3581 28 µM -0.506102809498016 0.316182903225276 no 2309 0.306392239185929 755 2877249
SGTC_2186 6124449 200 µM -0.506146313034905 0.316168265696983 no 2310 0.30637697021579 742 3834182 YLR033W RSC58
SGTC_1135 dihydrocapsaicin 536.708 nM -0.509232426275593 0.315130625032176 no 2311 0.305294658347078 774 107982 A Capsaicinoid.
SGTC_1089 terbinafine 2.25 µM -0.509623481708417 0.314999244711656 no 2312 0.305157634858064 758 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1560 lithocholic acid 53.1 µM -0.510162617597342 0.314818153151086 no 2313 0.304968769636179 747 9903 A bile acid which acts as a detergent.
SGTC_932 2857-0803 154 µM -0.51546022638219 0.313041101023372 no 2314 0.303115728079479 773 674898
SGTC_285 1486-1325 46 µM -0.516992403881776 0.312527947192758 no 2315 0.302580730728326 757 22310230
SGTC_1553 gossypol 38.6 µM -0.520437823861935 0.311375342011159 no 2316 0.301379226581364 761 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_277 nystatin 15.5 µM -0.522263243406005 0.310765427248363 no 2317 0.30074352877513 782 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_882 0843-0131 351 µM -0.522783836710235 0.310591580175233 no 2318 0.300562344399177 760 5425421
SGTC_104 0074-0074 590.992 µM -0.523988600015068 0.310189423409027 no 2319 0.300143234466275 754 3943124
SGTC_2796 7949634 45.45 µM -0.52605370222591 0.309500608645077 no 2320 0.299425447561876 755 2971588
SGTC_2873 9040596 71.43 µM -0.52612022086893 0.309478432458318 no 2321 0.299402339998665 822 6463863
SGTC_2024 5144227 134 µM -0.526947883922339 0.309202561681154 no 2322 0.299114890116185 755 3475211
SGTC_1689 st020265 53.493 µM -0.526969818165605 0.309195252176871 no 2323 0.299107273991365 778 5758320 YPR016C TIF6
SGTC_2406 ethylparaben 405.7 µM -0.528093988778372 0.308820727718083 no 2324 0.298717051415431 768 8434 A possible steroid mimic.
SGTC_2871 9038510 12.99 µM -0.529408800694583 0.308382942046214 no 2325 0.298260947211377 807 4945164
SGTC_2358 9037157 4 µM -0.533792163148727 0.306925408133114 no 2326 0.296742668191361 776 2388925
SGTC_3233 9132340 49.47 µM -0.534409978808812 0.306720219573928 no 2327 0.296528958265962 817 17682950
SGTC_2205 7238770 200 µM -0.534681597625502 0.30663002885776 no 2328 0.296435024347598 759 279867
SGTC_2702 st077768 96.8 µM -0.534816557480586 0.306585219946552 no 2329 0.296388356261832 743 6484119
SGTC_1505 k297-0037 20.6 µM -0.5353939257275 0.306393556755328 no 2330 0.296188744773383 757 4089396
SGTC_1283 0922-0125 16.4 µM -0.536588686892817 0.305997111996902 no 2331 0.295775880184635 764 3360884
SGTC_2849 9019321 12.99 µM -0.538337043707199 0.305417383025198 no 2332 0.295172190756998 745 16489627
SGTC_500 h-89 112 µM -0.540272989609935 0.304776021196963 no 2333 0.294504391423001 802 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1371 2421-0008 32.7 µM -0.542165106204437 0.304149758803749 no 2334 0.293852385461608 785 2827552
SGTC_1234 0326-0494 15.5 µM -0.542666641070765 0.303983854420702 no 2335 0.2936796731799 798 1547813
SGTC_3252 9135871 49.47 µM -0.544195375968209 0.303478408241797 no 2336 0.293153516743779 782 17682838
SGTC_454 lyso-paf C-16 6.67 µM -0.544408758103163 0.303407887494854 no 2337 0.293080110153714 798 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2390 9097792 176.6 µM -0.545349058301031 0.303097214569403 no 2338 0.292756734677771 760 4497149
SGTC_1650 st011916 45.8 µM -0.546931925995729 0.302574560548146 no 2339 0.292212750504867 803 242528
SGTC_2380 9035439 200 µM -0.54797740587207 0.302229570632219 no 2340 0.291853708495248 767 6462575
SGTC_1219 1469-0211 33.1 µM -0.549906392873273 0.301593502742033 no 2341 0.291191789603579 794 6822282
SGTC_417 st075190 100 µM -0.551172190953584 0.301176443541318 no 2342 0.290757820752396 783 222757
SGTC_1647 st011722 22.4 µM -0.551628051726 0.301026308737926 no 2343 0.290601606597581 776 2854783
SGTC_3217 9129673 49.47 µM -0.552339142930841 0.300792182821127 no 2344 0.290358008627035 785 17248312
SGTC_1401 3807-4679 7.6 µM -0.553025596058184 0.300566246926158 no 2345 0.290122941646393 789 3291456
SGTC_779 1360-0071 233 µM -0.554237652381031 0.300167503733271 no 2346 0.289708106554129 789 7566
SGTC_2223 6903751 107.57 µM -0.554427841503617 0.300104956892166 no 2347 0.289643038218975 787 5598863
SGTC_3032 9089427 49.47 µM -0.555476007023239 0.299760356127888 no 2348 0.289284558385131 771 17173707
SGTC_1861 st057647 17.4 µM -0.556787298208426 0.299329501203371 no 2349 0.288836381593787 784 688668
SGTC_2676 harmalol 100 µM -0.556796749620115 0.299326396744167 no 2350 0.288833152450379 765 5459187 A monoamine oxidase inhibitor
SGTC_1987 st072290 61.9 µM -0.558291588003228 0.298835578389356 no 2351 0.288322644083226 784 54697379
SGTC_219 mitoxanthrone 164.414 µM -0.558724401022863 0.298693535960542 no 2352 0.28817491180853 795 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1222 0366-0074 1.18 µM -0.558748130839477 0.298685749095435 no 2353 0.288166813131637 789 286520
SGTC_206 4546-0025 72.014 µM -0.560510502899443 0.298107690373161 no 2354 0.287565638876968 816 6620745 YIL048W NEO1
SGTC_24 0417-1663 219 µM -0.561191652886851 0.29788440955866 no 2355 0.287333446319737 803 4329390
SGTC_2412 st077135 33.4 µM -0.562819701769406 0.297351044686398 no 2356 0.286778831545199 808 13258915
SGTC_2480 5767542 37.17 µM -0.564312889646155 0.296862245529369 no 2357 0.286270605384565 779 2867358
SGTC_1295 1013-0063 9.78 µM -0.564393117342991 0.29683599318476 no 2358 0.286243310941994 785 6826038
SGTC_1872 amphotericin b 148 nM -0.56525665315334 0.296553491733484 no 2359 0.285949603775678 767 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_654 1124-0271 80.9 µM -0.566597084443575 0.29611522047146 no 2360 0.285493978136766 787 5403748
SGTC_2792 7535235 81.82 µM -0.570904002181848 0.294709034108941 no 2361 0.284032358940103 756 1281891
SGTC_1663 st014140 55.4 µM -0.574654081925005 0.293487166401929 no 2362 0.282762634040953 771 4207120
SGTC_2594 a-mangostin 100 µM -0.575655383841279 0.2931613150719 no 2363 0.282424068971072 806 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1359 1582-0056 520 nM -0.576488826174688 0.292890217890281 no 2364 0.282142410166341 807 3661189
SGTC_2436 5633522 8.09 µM -0.576971475539544 0.292733277786927 no 2365 0.281979362422617 793 5724242
SGTC_1032 k061-1018 98.7 µM -0.576974004840098 0.292732455452811 no 2366 0.28197850809839 809 4005393
SGTC_1320 1313-0481 95.3 µM -0.57818854293008 0.292337705026075 no 2367 0.281568416529917 788 6813365 YLR208W SEC13
SGTC_2627 acetyl isogambogic acid 100 µM -0.57840284761999 0.292268077195895 no 2368 0.281496085928411 794 6857789 A caspase activator and apoptosis inducer.
SGTC_1369 1866-0067 208 µM -0.578694767455717 0.292173244531674 no 2369 0.28139757363639 787 3531355
SGTC_1101 ebselen 5.29 µM -0.579572312621462 0.2918882527008 no 2370 0.281101534387889 802 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2743 auranofin 4.32 µM -0.580513697715324 0.291582672223662 no 2371 0.280784126140109 754 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1798 st045719 60.953 µM -0.580518258257235 0.29158119220158 no 2372 0.280782588877169 785 3980186
SGTC_656 4090-1979 187 µM -0.582076043141633 0.291075852958897 no 2373 0.280257730558793 787 22330961
SGTC_3347 9188721 44.724 µM -0.582582906787607 0.290911516651041 no 2374 0.280087057519449 799 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1415 3966-0071 78.1 µM -0.583273454855227 0.290687695632165 no 2375 0.279854614665609 789 2893185
SGTC_2921 7974240 10.71 µM -0.584928513687644 0.290151584683713 no 2376 0.27929789253525 793 2979074 YDR527W RBA50
SGTC_3266 9136860 49.47 µM -0.587082921710537 0.289454418140143 no 2377 0.278574008465672 784 4871271 YPR165W RHO1
SGTC_1408 3909-7976 48.8 µM -0.587537886807966 0.289307292097898 no 2378 0.278421256508217 784 24152374
SGTC_2730 imipramine 71.33 µM -0.587560750856214 0.289299899278203 no 2379 0.278413581110613 777 3696 A tricyclic antidepressant.
SGTC_391 gliotoxin 8.33 µM -0.587899130161962 0.289190498711311 no 2380 0.278300000172396 806 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1762 st045503 25.4615 µM -0.588932977263356 0.288856368739932 no 2381 0.277953117402244 792 4645554
SGTC_1867 st057372 64 µM -0.591049137797456 0.288173012116258 no 2382 0.277243748802636 766 688837
SGTC_1991 st073000 8.92 µM -0.59309745832707 0.287512289875709 no 2383 0.276557965672693 811 4301969 YIL048W NEO1
SGTC_3282 9108498 15.4605 µM -0.593705999899462 0.287316132067642 no 2384 0.276354384688937 798 16459645
SGTC_2700 st077718 96.8 µM -0.594267835263273 0.287135085816308 no 2385 0.276166494049363 785 904970
SGTC_1021 4476-0760 85.3 µM -0.594652633755031 0.287011119232376 no 2386 0.276037844790629 779 746768
SGTC_2445 5742597 35.57 µM -0.59662304590105 0.286376729338716 no 2387 0.275379540576933 797 1774255
SGTC_1043 0916-0009 19.3 µM -0.596663651305751 0.28636366310729 no 2388 0.275365982655251 815 3101130
SGTC_887 0885-0007 9.62 µM -0.596721379345263 0.286345087547006 no 2389 0.275346708145269 795 5719458
SGTC_2194 5927483 104.545 µM -0.597301522393338 0.286158442573807 no 2390 0.275153044119985 763 760979
SGTC_462 ag-879 158 µM -0.597506930685132 0.28609237199509 no 2391 0.275084490567605 809 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.597548914192951 0.286078868687207 no 2392 0.275070479906772 796 1241132 A phosphatase inhibitor.
SGTC_187 1488-2104 32.728 µM -0.598069685022911 0.285911396456692 no 2393 0.274896718425861 787 2852859
SGTC_3080 9117754 49.47 µM -0.598630101357424 0.285731226898092 no 2394 0.27470978919081 814 9550191
SGTC_3345 9148410 3.559 µM -0.601418408382694 0.284835611324609 no 2395 0.273780670403962 803 4903596
SGTC_1278 0874-0585 172 µM -0.601667976338112 0.284755514433444 no 2396 0.273697585285702 787 766306
SGTC_540 1187-0821 17.3 µM -0.602557254772748 0.284470194874744 no 2397 0.273401631879286 817 847520
SGTC_97 0535-0701 19.132 µM -0.60304899197976 0.28431248265277 no 2398 0.273238048945943 782 2832013 YGL099W LSG1
SGTC_1792 st045773 43.6 µM -0.603473241376817 0.284176449022306 no 2399 0.273096955704663 757 2919270
SGTC_1885 st057546 99.9 µM -0.60551632204788 0.283521780750296 no 2400 0.272417991460598 783 702008
SGTC_1587 estradiol valerate 56.1 µM -0.607803547089459 0.282789739396717 no 2401 0.271658888227252 812 13791 A steroid.
SGTC_2514 salinomycin 42.74 µM -0.608507791638958 0.282564524279509 no 2402 0.27142536992367 802 23682228 A polyether potassium ionophore.
SGTC_749 1000-0129 128 µM -0.609343143584849 0.282297493294801 no 2403 0.271148507846985 817 708470
SGTC_2035 5154463 94.595 µM -0.60974638496061 0.282168635474834 no 2404 0.2710149113043 817 2769623
SGTC_953 1188-0045 9.7 µM -0.610430129849929 0.281950206068066 no 2405 0.270788457155047 798 6144426
SGTC_1760 st045453 10.4495 µM -0.610444200959468 0.281945711761479 no 2406 0.270783797840116 814 3323419 YIL048W NEO1
SGTC_1382 3002-2117 298 µM -0.613803623906055 0.280873702328015 no 2407 0.269672551129456 834 1497314
SGTC_2075 5212009 200 µM -0.614469267986549 0.280661525944149 no 2408 0.269452637520604 817 780898
SGTC_2350 9023895 38.85 µM -0.615012474478724 0.280488434446335 no 2409 0.269273241132242 808 2997209
SGTC_2375 9072683 200 µM -0.615528896193149 0.280323925782496 no 2410 0.269102746100069 815 16798029
SGTC_2585 alliin 100 µM -0.616093496484573 0.280144123083682 no 2411 0.268916407066475 819 87310 A garlic compound which reacts with lipids.
SGTC_881 0833-0569 170 µM -0.616176254670593 0.280117772595401 no 2412 0.268889099241008 771 5418700
SGTC_641 4092-0595 30 µM -0.618143733215489 0.27949167469793 no 2413 0.2682402981312 807 786260
SGTC_986 1493-0483 84 µM -0.618373284734216 0.279418670303374 no 2414 0.268164651934785 808 40079
SGTC_352 k048-0007 5.11 µM -0.61838195936062 0.279415911688843 no 2415 0.268161793516902 823 6811911
SGTC_941 3237-0776 460 µM -0.619133404652834 0.279176995087455 no 2416 0.267914239371798 808 760008
SGTC_1720 st037298 9.481 µM -0.619163626103424 0.279167388473181 no 2417 0.267904285705241 820 597396
SGTC_1303 1160-0052 261 µM -0.619922155889095 0.278926324200579 no 2418 0.267654519120093 801 3562476
SGTC_2515 chrysin 20.77 µM -0.622171682517829 0.278212010315153 no 2419 0.266914492036351 788 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3075 9116269 49.47 µM -0.624841750882195 0.277365317183284 no 2420 0.266037462800485 818 17015205 YNL244C SUI1
SGTC_1715 st032160 10.2275 µM -0.625292299887221 0.277222569988673 no 2421 0.265889616397253 787 5289825
SGTC_3194 9111903 49.47 µM -0.625491696266172 0.277159406816756 no 2422 0.265824198322818 827 17087251
SGTC_2880 9042983 58.44 µM -0.625618794572468 0.277119149318305 no 2423 0.26578250409756 822 6464714
SGTC_2086 5274770 176.623 µM -0.626137495957399 0.27695488396051 no 2424 0.265612380012149 804 689278
SGTC_450 aminopyrene 156 nM -0.627454698549778 0.276537958980135 no 2425 0.26518061120872 815 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_269 exalamide 29 µM -0.627528500753429 0.276514607987715 no 2426 0.265156429966838 799 3316 A derivative of salicylamide.
SGTC_1866 st057638 64 µM -0.629190005623755 0.275989164422004 no 2427 0.264612335577985 796 688802
SGTC_403 arphamenine a 50 µM -0.629350189556954 0.27593853288951 no 2428 0.264559910043302 815 5487158 An arginine aminopeptidase inhibitor.
SGTC_1299 1079-1439 3.74 µM -0.629931959028289 0.275754683419141 no 2429 0.264369551038365 814 323161
SGTC_2957 9076800 11.52 µM -0.630402591947292 0.275605999133331 no 2430 0.26421560771745 818 16459615
SGTC_2312 7706453 155.7 µM -0.632182999297393 0.275043882415504 no 2431 0.263633652466759 807 976098
SGTC_3003 9075612 71.4286 µM -0.633589805315138 0.274600120250989 no 2432 0.263174277868029 824 6501993
SGTC_2367 9070478 135.38 µM -0.633614083127936 0.274592465171354 no 2433 0.263166353848173 793 572802
SGTC_3209 9113616 49.47 µM -0.635343053875661 0.274047571234296 no 2434 0.262602349798148 819 16649353
SGTC_1075 aripiprazole 15.2 µM -0.638302297753119 0.273116192051862 no 2435 0.261638458277765 803 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3270 9137563 49.47 µM -0.638531655001814 0.273044070734225 no 2436 0.261563827411872 795 17015724
SGTC_1815 st051655 58.2 µM -0.639192864367546 0.272836206501497 no 2437 0.261348736777786 816 5984156
SGTC_1688 st021091 57.6 µM -0.640610974414897 0.272390660445312 no 2438 0.26088773380312 829 3656366
SGTC_1791 st048313 56.1 µM -0.641301119455446 0.272173959426675 no 2439 0.260663531023783 797 1204976
SGTC_2917 7979103 53.79 µM -0.641407323464146 0.272140619673591 no 2440 0.260629038048006 806 2980565
SGTC_255 tunicamycin 200.472 nM -0.641866593254928 0.27199646825224 no 2441 0.26047990329418 802 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1000 4048-0884 8.67 µM -0.64228522911403 0.271865103730717 no 2442 0.260344001544567 818 13040088
SGTC_2057 5236571 38.335 µM -0.6423558310093 0.27184295254225 no 2443 0.26032108565301 810 54684039 YBR257W POP4
SGTC_2780 5215298 71.43 µM -0.643272085675132 0.271555561144428 no 2444 0.260023782926981 825 2834131
SGTC_1742 st038235 28.8875 µM -0.645273019751389 0.270928476918433 no 2445 0.259375136872866 834 564103 YBR002C RER2
SGTC_845 0330-0138 4.51 µM -0.646083281599546 0.270674750001243 no 2446 0.259112710967092 817 9039800
SGTC_1405 3909-7894 12 µM -0.648009878595565 0.270071928696001 no 2447 0.258489280493149 818 7104060
SGTC_67 0335-0847 266 µM -0.652033768691943 0.268815046564421 no 2448 0.257189694155546 830 4552207 YOR254C SEC63
SGTC_2055 5235184 200 µM -0.652874006497467 0.268552965354955 no 2449 0.256918753892296 840 2836034
SGTC_1636 st007707 68.9 µM -0.654044054789929 0.268188225994915 no 2450 0.256541711591712 835 403051
SGTC_1207 2099-0101 141 µM -0.655672384484929 0.267681041682855 no 2451 0.256017470434994 816 5837381
SGTC_2362 9071156 126 µM -0.656416953172494 0.267449288167549 no 2452 0.255777942689491 827 653133
SGTC_651 3253-0966 34.4 µM -0.659105205866249 0.26661338912875 no 2453 0.254914106476608 821 781462
SGTC_2045 5106652 78.05 µM -0.659256699701371 0.266566322209434 no 2454 0.254865471321095 809 673349
SGTC_108 0509-0257 621.132 µM -0.660581707270278 0.266154840903042 no 2455 0.254440301699591 823 536624
SGTC_1531 st059297 52.4 µM -0.663952056801618 0.265109629791125 no 2456 0.253360498343305 824 7566702
SGTC_2973 9094665 17.96 µM -0.664805886705059 0.264845171858038 no 2457 0.253087328499989 831 25237061 YIL048W NEO1
SGTC_2118 5526350 200 µM -0.665477730399878 0.264637175082592 no 2458 0.252872491336932 825 743594
SGTC_617 3770-0098 35 µM -0.667149102534374 0.26412009398245 no 2459 0.252338449157752 824 5962639
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.667455145976363 0.264025467511436 no 2460 0.25224072561877 837 23665772 A membrane-active detergent.
SGTC_1854 st056233 32.9 µM -0.668369083426069 0.263742987369835 no 2461 0.251949012664813 842 5393174
SGTC_2074 5212007 75.395 µM -0.670872626213047 0.262969981596101 no 2462 0.251150838040778 812 758611
SGTC_623 k072-0108 16.9 µM -0.670995753808188 0.262931994036233 no 2463 0.25111161727682 823 5382803
SGTC_1260 0700-1617 7.75 µM -0.671276454520144 0.26284540220807 no 2464 0.251022215670522 806 2853078
SGTC_1422 4031-0024 15.5 µM -0.671710004033761 0.262711687550818 no 2465 0.250884165676928 843 782427
SGTC_1579 chlormadinone acetate 49.4 µM -0.672401927689129 0.262498357658055 no 2466 0.25066392796536 833 45114258 A steroidal progestin.
SGTC_2015 5119600 184 µM -0.673268222071282 0.262231391862305 no 2467 0.250388332877736 835 2828786
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.674210017309209 0.261941316870031 no 2468 0.250088900943415 831 688788
SGTC_1117 retinoic acid 1.10837 µM -0.674602005594868 0.26182063212945 no 2469 0.249964329214609 827 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3300 9124615 50.48 µM -0.675275461177119 0.26161335628982 no 2470 0.249750385630921 821 24824903
SGTC_1044 1222-0021 1.78 µM -0.67542984136539 0.261565853097464 no 2471 0.249701355786647 822 4306703
SGTC_2831 7999036 19.48 µM -0.676289588143808 0.261301387750713 no 2472 0.249428400997148 826 2988270
SGTC_538 2922-0838 53.3 µM -0.677108342757779 0.26104965969783 no 2473 0.249168608005207 820 777039
SGTC_2684 capsaicin 100 µM -0.678986792531696 0.260472597345112 no 2474 0.248573115226257 842 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.683381030289935 0.259125251814749 no 2475 0.247183051826792 858 368090
SGTC_3150 9097574 49.47 µM -0.684746334846036 0.258707361886146 no 2476 0.246752002442044 815 17217476
SGTC_2461 5755302 26.15 µM -0.685203993119115 0.258567360784119 no 2477 0.246607602221828 857 2788904
SGTC_2639 lactacystin 53 µM -0.685614274231555 0.258441886070734 no 2478 0.246478188918099 823 3870 A proteasome inhibitor.
SGTC_2105 5350118 200 µM -0.688045429001938 0.257699022989297 no 2479 0.245712086893872 833 2133313
SGTC_2505 galangin 7.89 µM -0.689069909049719 0.257386315424711 no 2480 0.245389637532657 842 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_843 0310-0051 143 µM -0.689570908596571 0.25723346445409 no 2481 0.245232033566214 838 2065037
SGTC_3108 9121785 49.47 µM -0.689796915136419 0.257164527107299 no 2482 0.245160954458299 824 17140271
SGTC_1895 st058434 18.3 µM -0.691392946307264 0.256677973390262 no 2483 0.244659317814472 851 5393175
SGTC_2960 9079389 5.97 µM -0.691394589503002 0.256677472705431 no 2484 0.24465880163886 814 16457355
SGTC_2989 9073649 71.4286 µM -0.692162875738582 0.256443430160024 no 2485 0.244417524816982 847 21367202
SGTC_2064 5220758 200 µM -0.692877439369576 0.256225852939703 no 2486 0.244193234466168 826 788518
SGTC_2324 6149169 200 µM -0.693190575533288 0.256130536561286 no 2487 0.24409498090258 826 2888231
SGTC_685 1278-0033 54.9 µM -0.693867642997928 0.255924505366952 no 2488 0.243882608560546 844 3590572
SGTC_1692 fluoroquinolonic acid 71 µM -0.694856980106161 0.255623606301197 no 2489 0.243572467549922 837 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1874 staurosporine 7.6 µM -0.695585556479851 0.255402133745602 no 2490 0.243344207030322 831 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1423 4048-0112 5.59 µM -0.695808539849142 0.255334371335852 no 2491 0.243274370204178 819 X1423
SGTC_2906 7926292 26.41 µM -0.696771287936928 0.255041909758739 no 2492 0.242972968659467 857 2966319
SGTC_2316 5844804 197.44 µM -0.696809947938717 0.255030169366091 no 2493 0.242960869833696 831 776813
SGTC_2401 5128683 200 µM -0.69807652180124 0.254645688598675 no 2494 0.242564670010717 842 708373
SGTC_672 1441-0018 53.7 µM -0.698279535537549 0.254584090053028 no 2495 0.242501197378179 820 251141
SGTC_2374 9071832 200 µM -0.698374350268411 0.254555323986521 no 2496 0.242471556453615 825 17381698
SGTC_398 bronopol 33.3 µM -0.698417740813029 0.254542160194018 no 2497 0.242457992382055 823 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1704 st028805 70.8 µM -0.699732734913821 0.254143387458901 no 2498 0.24204711460355 841 2876101
SGTC_340 k038-0059 454 µM -0.700759807267874 0.25383215521277 no 2499 0.241726462519956 836 23733424
SGTC_1191 1487-1166 10.6 µM -0.701306984344159 0.25366642666401 no 2500 0.241555727968093 854 3955771
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.701910732157418 0.253483629982367 no 2501 0.241367417778628 839 521171
SGTC_1248 0469-0687 58.6 µM -0.703536955528189 0.252991602973044 no 2502 0.240860592327867 828 4017482
SGTC_1846 st056244 14.8 µM -0.706950221178463 0.25196052849746 no 2503 0.239798706441866 850 5393182
SGTC_546 peri-Naphthalide 147 µM -0.707455596658454 0.251808054083791 no 2504 0.239641698692677 815 223824 A penicillin ester.
SGTC_1985 st071382 65.5 µM -0.707714004257962 0.251730109992042 no 2505 0.239561439482674 846 6123237
SGTC_534 k292-0788 63.4 µM -0.708494099314177 0.251494885394092 no 2506 0.239319237610907 862 4146317
SGTC_746 1095-0025 46.6 µM -0.709002189518323 0.251341741786346 no 2507 0.239161559056586 843 6749286
SGTC_1187 1391-0724 117 µM -0.709875803027491 0.251078540996683 no 2508 0.238890578336448 837 6997986
SGTC_2020 4017018 200 µM -0.710033473515368 0.251031053838461 no 2509 0.238841689405611 846 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1194 1488-0194 225 µM -0.710776319344418 0.250807387668053 no 2510 0.238611428641837 845 1391452
SGTC_1772 st048439 82.2 µM -0.711801673630223 0.250498833403924 no 2511 0.238293798095488 825 2927068 YDL195W SEC31
SGTC_715 0868-0130 184 µM -0.714316843630327 0.249742809713694 no 2512 0.237515639573809 850 2876258
SGTC_2506 ethyl hematommate 54.16 µM -0.715524597990479 0.249380207299047 no 2513 0.237142473472578 846 3940691 An allergen.
SGTC_1139 k015-0024 46.9 µM -0.71554423585723 0.249374313762532 no 2514 0.23713640852199 843 2766652
SGTC_2642 cholecalciferol 100 µM -0.71568596235038 0.249331782302176 no 2515 0.237092640297884 834 9821465 A vitamin D precursor, similar to steriods.
SGTC_2282 7944268 200 µM -0.717014285685191 0.248933346173595 no 2516 0.236682640996268 845 2970414
SGTC_2183 6420625 130.508 µM -0.717347420364671 0.248833474211235 no 2517 0.236579877095893 849 2897619
SGTC_2705 st078069 42.8 µM -0.717354299473964 0.248831412116547 no 2518 0.236577755317676 836 1530061
SGTC_1808 st050063 61.5 µM -0.718081923065054 0.248613349686351 no 2519 0.236353387739314 857 4011993
SGTC_1023 4482-3888 16 µM -0.718335719709944 0.248537313002574 no 2520 0.236275155420549 844 3303168
SGTC_621 3584-0052 32.1 µM -0.718457514216828 0.248500828148088 no 2521 0.236237617566255 849 2273927
SGTC_467 ro 31-8220 72.8 µM -0.719255301869156 0.248261912864397 no 2522 0.235991815488903 845 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_802 4112-3352 742 µM -0.719276743143415 0.248255493487689 no 2523 0.23598521127821 816 704594
SGTC_2955 9076254 12.21 µM -0.722379649546076 0.247327437602373 no 2524 0.23503054757976 826 16459619
SGTC_1765 st044815 90.4 µM -0.722520721676119 0.247285288114494 no 2525 0.234987195024289 855 645695
SGTC_2739 tacrine 100.86 µM -0.723892630011941 0.24687559010866 no 2526 0.234565827481182 829 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2531 methyl deoxycholate 70.07 µM -0.725490296087625 0.246398931528838 no 2527 0.234075647957643 851 16667744 Haematoxylin.
SGTC_1306 1185-0270 9.02 µM -0.726090934341331 0.246219860675284 no 2528 0.233891513120993 849 1548076
SGTC_381 3461-2219 42.7 µM -0.72634149422134 0.246145180817511 no 2529 0.233814723890334 859 2883159
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.728117854586052 0.245616081697097 no 2530 0.233270722547002 851 616764
SGTC_2478 5763493 32.33 µM -0.728609690837519 0.245469693502228 no 2531 0.233120224454721 840 1365576 YLR208W SEC13
SGTC_2157 5649910 96.377 µM -0.730301424627416 0.244966530690202 no 2532 0.232602978808793 854 2858091
SGTC_1124 fisetin 1.16336 µM -0.734444928673082 0.243736499361289 no 2533 0.231338806359413 852 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1404 3909-7820 48.3 µM -0.735216853495506 0.243507716484608 no 2534 0.231103718244455 835 23741373
SGTC_503 tyrphostin 8 294 µM -0.735309320742278 0.243480318848342 no 2535 0.23107556647936 877 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2736 butenafine 14.65 µM -0.736057009936027 0.243258843031893 no 2536 0.230848001920925 845 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1479 0549-0158 134 µM -0.737517930322113 0.242826412775625 no 2537 0.230403721715985 854 5440202
SGTC_864 0469-0573 172 µM -0.737550337367631 0.242816825057116 no 2538 0.230393871838462 873 689425
SGTC_2499 avocadenofuran 51.48 µM -0.738175364842975 0.242631948949427 no 2539 0.230203945505604 855 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1496 4469-0713 57.4 µM -0.741401880893422 0.241678795115484 no 2540 0.229224902197051 854 746691
SGTC_3101 9120531 49.47 µM -0.742413197060321 0.241380458403675 no 2541 0.22891851307142 866 24824904
SGTC_1407 3909-7909 12.3 µM -0.747168616144132 0.239980303200941 no 2542 0.227480892842854 832 4411780
SGTC_2909 7941780 10.49 µM -0.747644405789646 0.239840458875345 no 2543 0.227337336290348 837 1243215
SGTC_762 1165-0429 115 µM -0.747987847998136 0.239739541805724 no 2544 0.227233743696512 850 5967793
SGTC_2902 5787006 60.46 µM -0.748178695496711 0.239683473187189 no 2545 0.227176189799521 845 591003
SGTC_2014 4013930 200 µM -0.749698947498577 0.239237097730586 no 2546 0.226718020788318 854 64556
SGTC_533 1222-0222 6.71 µM -0.750960057154737 0.238867156436914 no 2547 0.226338347335469 881 3982874
SGTC_3118 9124250 49.47 µM -0.751724126179918 0.238643172245789 no 2548 0.226108489245348 833 1504786
SGTC_934 2950-0684 338 µM -0.751842112630145 0.238608595173561 no 2549 0.226073006649214 851 1121253
SGTC_3093 9117344 49.47 µM -0.753631178376206 0.238084628272996 no 2550 0.225535358680223 834 24824913
SGTC_3133 9127736 49.47 µM -0.754349714166091 0.237874367027089 no 2551 0.225319628992724 846 27243420
SGTC_2845 9003024 42.97 µM -0.754584460726463 0.237805696482957 no 2552 0.225249175160131 839 2990173
SGTC_1941 st076221 61.8 µM -0.755251726392604 0.237610560270182 no 2553 0.225048978724737 825 2828568
SGTC_406 estrone 100 µM -0.757644739279377 0.236911466980118 no 2554 0.224331844609726 851 5870 A steroid.
SGTC_922 1866-0035 480 µM -0.763234104325326 0.235283007162009 no 2555 0.222661896499982 859 3156169
SGTC_1495 4469-0029 237 µM -0.764102415240225 0.235030580795577 no 2556 0.222403106558569 842 793680
SGTC_1330 1469-0054 61.8 µM -0.767817828697774 0.233952165777581 no 2557 0.221297710449019 858 7102664
SGTC_41 0478-0632 82.643 µM -0.767863825967686 0.233938832069821 no 2558 0.221284045231412 865 3750424
SGTC_2080 5212524 12.4 µM -0.768976722859562 0.233616353409306 no 2559 0.220953564520658 864 260183
SGTC_2980 9014342 25.29 µM -0.769305497671548 0.23352113313399 no 2560 0.220855987161022 849 2996599
SGTC_505 gw-5074 63.9 µM -0.769468036315851 0.233474066390034 no 2561 0.220807756291994 860 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_394 menadione 8.33 µM -0.769874611888923 0.233356356275473 no 2562 0.220687137593994 866 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2429 5902844 64.44 µM -0.770762999087277 0.233099268627218 no 2563 0.220423711301355 858 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_245 methotrexate 289.6 µM -0.773289082417386 0.232369113121861 no 2564 0.219675657765874 839 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3170 9103054 49.47 µM -0.775470222460873 0.231739687131039 no 2565 0.219030927240615 868 16432970
SGTC_634 1611-4317 11.2 µM -0.777073682891402 0.231277572484768 no 2566 0.218557649836864 876 2843522
SGTC_2061 5245884 80.95 µM -0.777323117203467 0.231205732158192 no 2567 0.218484079759061 871 573863
SGTC_1077 5-fluorocytosine 377 nM -0.778932048572051 0.230742638277653 no 2568 0.218009871946852 883 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_154 3389-1638 511.116 µM -0.782073879243927 0.229839830092709 no 2569 0.217085578325439 889 5238686
SGTC_1358 1509-0022 2.48 µM -0.783117988038276 0.229540242783831 no 2570 0.216778914467121 878 3258434
SGTC_2634 4'-methoxyflavone 100 µM -0.785006279571216 0.228998989245305 no 2571 0.21622494340932 868 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_334 1502-1024 68.5 µM -0.786164749689673 0.228667283997482 no 2572 0.215885487287463 866 3296216
SGTC_1275 0867-0008 21.1 µM -0.786167630162873 0.228666459566752 no 2573 0.215884643633264 866 3422836
SGTC_51 1013-0126 23.419 µM -0.78777978114324 0.22820530192768 no 2574 0.215412764821522 849 1627850
SGTC_2447 5741742 33.78 µM -0.788126988106295 0.228106051450821 no 2575 0.215311215233189 869 1776504
SGTC_1450 4112-4260 37.6 µM -0.789942661631091 0.227587429576657 no 2576 0.214780627563274 867 1633175
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.789962732095662 0.227581700440356 no 2577 0.214774766692755 835 279621
SGTC_2305 7443522 69.23 µM -0.790209844612497 0.227511168554725 no 2578 0.214702613822878 852 5415886
SGTC_315 k915-0449 187 µM -0.790912408936071 0.227310706983358 no 2579 0.214497553340355 850 20970215 YNL149C PGA2
SGTC_376 3970-0862 59.1 µM -0.791393800556884 0.22717340974917 no 2580 0.214357113254176 878 3135186
SGTC_834 0312-0008 75.7 µM -0.791488961798766 0.227146274438712 no 2581 0.214329357464025 879 6385573 YIL048W NEO1
SGTC_1790 st045711 43.5 µM -0.79177177284065 0.227065641409913 no 2582 0.214246881976817 825 585119
SGTC_2099 5377090 177.372 µM -0.791997886853671 0.227001185037002 no 2583 0.214180954188372 869 2243829
SGTC_2519 cryptotanshinone 88.04 µM -0.792380883138274 0.226892031129607 no 2584 0.21406931136012 856 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3060 1327-0027 12.5 µM -0.792391042918804 0.226889135996196 no 2585 0.214066350260921 848 16000455 YPR107C YTH1
SGTC_323 4013-0906 34.3 µM -0.793330029989952 0.226621651996293 no 2586 0.213792782526681 833 2910086
SGTC_831 k061-1017 217 µM -0.794399652827005 0.226317171489664 no 2587 0.213481403117905 884 1240153
SGTC_280 3448-3607 3.04 µM -0.795792847464398 0.225920929262967 no 2588 0.21307622486419 847 626179
SGTC_2286 7945697 125 µM -0.795862566916528 0.225901110478025 no 2589 0.213055960376902 873 1245733
SGTC_3081 9117243 49.47 µM -0.796396566733464 0.225749345741054 no 2590 0.212900786571325 862 45595589
SGTC_2179 6298986 200 µM -0.798084354202178 0.225270049668166 no 2591 0.212410770098913 847 738374
SGTC_179 1273-0063 6.77 µM -0.799756480088047 0.224795769998844 no 2592 0.211925951116277 886 3108139
SGTC_913 3487-1245 167 µM -0.799994429183811 0.224728324466617 no 2593 0.211857012405385 865 4016153
SGTC_1736 st036774 51 µM -0.801578144987484 0.224279720280745 no 2594 0.211398511975211 886 1272247
SGTC_542 3381-0244 89.3 µM -0.801600782008062 0.224273311793839 no 2595 0.211391962563191 886 1112843
SGTC_288 1315-0019 35.1 µM -0.801667936528377 0.224254301119891 no 2596 0.211372533911242 869 6811474
SGTC_683 panaxydol 45 µM -0.801949763621591 0.224174529082172 no 2597 0.21129100917488 846 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1673 st016611 27.3 µM -0.803394087557075 0.223765961692135 no 2598 0.210873495644376 890 5226799
SGTC_2856 9022925 19.48 µM -0.803747344338539 0.223666097603792 no 2599 0.21077145270123 867 4944862
SGTC_1094 duloxetine 25.4 µM -0.807251732748981 0.222676796577599 no 2600 0.209760733105218 848 60834 A selective serotonin reuptake inhibitor.
SGTC_687 k029-0044 34.9 µM -0.807310818131222 0.22266013797788 no 2601 0.209743716434529 853 5829338
SGTC_1483 3453-0561 55.9 µM -0.810298084179123 0.221818831175445 no 2602 0.208884438091512 903 4546991
SGTC_2116 5511452 16.8835 µM -0.812912428653702 0.221084042866066 no 2603 0.208134134067595 881 870744
SGTC_2994 9053520 71.4286 µM -0.813265530064213 0.220984906970143 no 2604 0.208032917756729 874 4647384
SGTC_1284 0929-0043 16 µM -0.813474047498471 0.220926376071949 no 2605 0.207973160005217 882 1239883
SGTC_2275 7947463 200 µM -0.814799048062757 0.220554655495173 no 2606 0.207593672964778 858 1225414
SGTC_548 1436-0017 110 µM -0.814843323023171 0.220542240623908 no 2607 0.207580999454958 864 9677137
SGTC_2351 9026858 72.31 µM -0.815151343610894 0.220455881535639 no 2608 0.207492842591864 911 1409300
SGTC_247 mechlorethamine 29.705 µM -0.815325297450955 0.220407119025463 no 2609 0.207443066007311 855 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1983 st071813 46.9 µM -0.815759185679721 0.22028551899598 no 2610 0.20731894042002 876 11838595
SGTC_2207 7258803 200 µM -0.816170675409367 0.220170231838621 no 2611 0.2072012631189 864 3666799
SGTC_3328 9140624 29.0385 µM -0.817833963794534 0.219704580780487 no 2612 0.206726000796103 875 4904392
SGTC_2628 lathosterol 100 µM -0.818959201349618 0.219389882334644 no 2613 0.206404845620758 873 6710616
SGTC_529 4076-0302 30.3 µM -0.820591258449411 0.218933900789566 no 2614 0.205939564288081 888 5816522
SGTC_490 phenamil 164 µM -0.82419416364283 0.217929215111818 no 2615 0.204914621366963 868 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2292 7671323 168.05 µM -0.824453630089353 0.217856964541372 no 2616 0.204840926443466 896 937504
SGTC_697 0508-1955 564 µM -0.826867856138442 0.217185365998886 no 2617 0.204155982091953 862 6243113
SGTC_961 1252-1571 372 µM -0.830016500124 0.216311263913777 no 2618 0.203264727366001 894 6813498
SGTC_740 k014-0057 261 µM -0.833126984660173 0.215449758380256 no 2619 0.202386558106516 889 4012779
SGTC_2000 st075254 36.4 µM -0.837222774216781 0.214318396060858 no 2620 0.201233679184652 855 17234175
SGTC_119 0121-0043 24.815 µM -0.838973520155112 0.213835851228879 no 2621 0.200742084579681 900 1092378
SGTC_477 mead ethanolamide 10 µM -0.842644139835873 0.212826202408858 no 2622 0.199713748482747 852 16061185
SGTC_2928 9011484 9.79 µM -0.842936907767695 0.212745793010219 no 2623 0.199631865287311 874 2994751
SGTC_976 1348-1067 47.6 µM -0.844930717590507 0.212198660355133 no 2624 0.199074761335638 889 5310671 YGL099W LSG1
SGTC_925 2064-1272 59.6 µM -0.845220481819579 0.212119213025852 no 2625 0.198993874371927 900 6815817
SGTC_2532 xanthone 78.9 µM -0.846111300200742 0.211875078085856 no 2626 0.198745328697942 879 7020 An insecticide.
SGTC_1482 3346-2049 8.48 µM -0.849523293122024 0.210941519657237 no 2627 0.197795087276553 876 3826804
SGTC_2689 tacrolimus 100 µM -0.849649778328177 0.210906958350199 no 2628 0.197759913944628 861 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_936 3005-4620 401 µM -0.850335383133232 0.210719678825638 no 2629 0.197569324970083 880 777207
SGTC_3186 9110464 49.47 µM -0.850974394031806 0.210545214739115 no 2630 0.197391788491266 875 17018021
SGTC_946 3434-1334 87.4 µM -0.85279167036946 0.210049521733225 no 2631 0.196887421974203 881 4047976
SGTC_728 3030-5151 22.5 µM -0.855563852802343 0.209294684085543 no 2632 0.196119535634593 881 3125388
SGTC_2999 9069765 71.4286 µM -0.855697292582386 0.209258390083818 no 2633 0.196082619086128 868 2097066
SGTC_1106 tegaserod maleate 11.7 µM -0.85827559185636 0.208557851570053 no 2634 0.19537015195696 891 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1460 k062-0059 9.15 µM -0.859112942033314 0.208330636573642 no 2635 0.195139103862128 870 1373085
SGTC_1263 0774-1208 64.8 µM -0.859571709007778 0.208206212083258 no 2636 0.195012587803154 897 906585
SGTC_2483 5729050 27.16 µM -0.860744982187125 0.207888202320641 no 2637 0.194689256348283 878 2865180
SGTC_3219 9131112 49.47 µM -0.861147133363506 0.207779267315976 no 2638 0.1945785063397 871 17612988 YMR079W SEC14
SGTC_3065 9113888 49.47 µM -0.861835529822 0.207592872254521 no 2639 0.194389015113393 892 16648368
SGTC_666 0272-0154 136 µM -0.862903256348407 0.207303962676162 no 2640 0.19409533007507 889 6870312
SGTC_2742 clothiapine 36.27 µM -0.863175678501216 0.207230287721374 no 2641 0.194020441915087 867 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_116 0155-0182 31.788 µM -0.866508708572668 0.206330143908021 no 2642 0.193105626382819 819 771486
SGTC_3010 9080089 71.4286 µM -0.866920141947992 0.206219189933199 no 2643 0.192992883301024 879 17027233
SGTC_3339 9145883 14.936 µM -0.86736364540173 0.206099627027466 no 2644 0.192871397241222 865 2030670
SGTC_1451 4152-0210 104 µM -0.867963656523502 0.205937937076925 no 2645 0.192707114405769 903 659563
SGTC_3164 9100705 49.47 µM -0.868004719521709 0.205926874243395 no 2646 0.192695874498206 856 17174235
SGTC_594 1487-1584 10.8 µM -0.869478352984918 0.20553009419187 no 2647 0.192292771587898 917 5013332
SGTC_704 1310-0270 142 µM -0.871625930723286 0.204952666177128 no 2648 0.19170623986384 896 5718033
SGTC_945 3381-0768 11.3 µM -0.87476932239653 0.204109230744193 no 2649 0.190849716180945 901 1126236 YIL048W NEO1
SGTC_314 1671-0008 2.74 µM -0.874889043786563 0.204077148004147 no 2650 0.190817140510301 893 3913060
SGTC_3144 9087057 49.47 µM -0.875836561366386 0.203823339799096 no 2651 0.190559445454741 879 17249618
SGTC_1719 st032227 49.2 µM -0.877984786755848 0.203248599514884 no 2652 0.18997598735697 890 3125804
SGTC_1570 verbenone 133 µM -0.87962899102354 0.202809360171079 no 2653 0.189530164145997 912 29025 A natural terpanoid with antifungal properties.
SGTC_2150 5556613 200 µM -0.880611907009274 0.202547051097466 no 2654 0.189263955840784 919 743190
SGTC_1041 0206-0046 107 µM -0.881039967108793 0.202432878868516 no 2655 0.189148094063608 923 50494
SGTC_117 lucigenin 22.078 µM -0.881339416261236 0.202353032643795 no 2656 0.18906706900617 930 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1039 k821-0043 94 µM -0.881496753047883 0.202311087332697 no 2657 0.189024505331072 883 15992768
SGTC_1603 st002045 67.8 µM -0.884423151011441 0.20153187048022 no 2658 0.188233915070729 908 5887985
SGTC_1119 parthenolide 318.541 nM -0.884757097976785 0.201443064320454 no 2659 0.188143826454058 938 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_182 3448-4371 550.524 µM -0.88524959281087 0.201312138499822 no 2660 0.188011015067527 875 3491403
SGTC_3251 9135047 49.47 µM -0.885655861215412 0.20120417369282 no 2661 0.187901499989842 882 17682963
SGTC_161 4065-0411 162.148 µM -0.88761375114269 0.200684356380184 no 2662 0.187374277101339 910 1906281 YLR208W SEC13
SGTC_324 1315-0088 19.6 µM -0.887864104775548 0.200617945989573 no 2663 0.187306927585512 925 6787421
SGTC_1834 st055981 52.8 µM -0.888171086139952 0.200536532179765 no 2664 0.187224364647745 878 471719 YDL150W RPC53
SGTC_16 erodoxin 22.806 µM -0.889412635787076 0.200207466140219 no 2665 0.18689067827068 882 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_899 1083-0020 478 µM -0.890239712649612 0.199988434076266 no 2666 0.186668592473099 911 767123
SGTC_3025 9087895 49.47 µM -0.891267936295855 0.199716333956073 no 2667 0.186392722885085 910 17173641
SGTC_2536 dehydroabietamide 32.04 µM -0.892987277820127 0.199261840349655 no 2668 0.185931992847453 903 3983547
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.896175812103723 0.198420628326812 no 2669 0.185079435966158 902 390807
SGTC_2997 9067075 71.4286 µM -0.89648738077367 0.198338544097143 no 2670 0.184996258533927 893 27209819
SGTC_1098 clofazimine 15.1 µM -0.898056473032113 0.197925470936023 no 2671 0.184577721430891 918 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1282 0886-0010 32.4 µM -0.898961294282682 0.197687507600494 no 2672 0.18433663879452 891 2836211 YNL267W PIK1
SGTC_1811 st050069 61.5 µM -0.899783948339971 0.197471303952989 no 2673 0.18411761909581 889 3877702
SGTC_251 melphalan 456.522 µM -0.899817016397623 0.197462616249076 no 2674 0.184108818593473 902 460612 A DNA alkylator.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.900146300733884 0.197376118642359 no 2675 0.184021199442318 894 688662
SGTC_1081 sertraline 6 µM -0.90105953476176 0.197136346939838 no 2676 0.183778333204846 893 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1611 st001856 99.4 µM -0.902172872037613 0.196844276198288 no 2677 0.183482521563047 914 647478
SGTC_2745 rifampicin 24.3 µM -0.902204946518102 0.196835865726077 no 2678 0.183474003833959 857 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3322 9139058 2.11 µM -0.906322203103664 0.19575805872076 no 2679 0.182382668420916 892 4908926 YPR165W RHO1
SGTC_1398 3558-0053 112 µM -0.908246250738493 0.195255615969961 no 2680 0.181874066568863 883 4532369
SGTC_2310 7668677 200 µM -0.911307179579944 0.194457906589923 no 2681 0.181066772293205 910 2197143
SGTC_3124 9127567 49.47 µM -0.912781323457657 0.194074438391215 no 2682 0.180678781437499 912 17592030
SGTC_137 0438-0332 85.389 µM -0.913242354879454 0.193954605185918 no 2683 0.180557546250067 908 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_766 1391-0721 126 µM -0.915348106851908 0.193407842896973 no 2684 0.180004455846941 933 1020919 YIL115C NUP159
SGTC_2915 7971052 15.16 µM -0.915754622998366 0.193302398645357 no 2685 0.179897804191855 862 5741558
SGTC_1552 6-methylflavone 10.6 µM -0.916775225862309 0.193037824062113 no 2686 0.179630218588222 900 689013
SGTC_2125 5246583 200 µM -0.91707237235747 0.192960835278311 no 2687 0.179552358606579 890 835267
SGTC_1974 st069448 26.9 µM -0.917917155607882 0.192742059722941 no 2688 0.179331119681346 887 6323587 YNR016C ACC1
SGTC_3058 9093861 49.47 µM -0.918001711760008 0.192720170359436 no 2689 0.179308984847901 886 17217477
SGTC_270 tamoxifen 5.46 µM -0.919660259904512 0.192291123035975 no 2690 0.178875162919972 927 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3207 9114163 49.47 µM -0.919721885312762 0.192275192516528 no 2691 0.17885905646874 931 849233
SGTC_2219 9098279 200 µM -0.920550322167183 0.192061115238176 no 2692 0.178642624372521 879 902349
SGTC_1031 k035-0009 16 µM -0.921774941564259 0.191744927273863 no 2693 0.178322990389339 921 5180959
SGTC_3292 9120825 59.784 µM -0.923588732001218 0.191277205627687 no 2694 0.17785024135775 887 24824900
SGTC_2474 5321570 43.32 µM -0.923794944536824 0.191224073967171 no 2695 0.17779654390725 918 2841384
SGTC_1967 st070177 51.4 µM -0.924502995155027 0.191041710165814 no 2696 0.177612246390563 931 5729214
SGTC_2809 7964133 12.99 µM -0.925314728362916 0.190832773406678 no 2697 0.177401109860526 932 1253665
SGTC_2466 5983409 37.09 µM -0.926518539635269 0.190523175636787 no 2698 0.177088283425934 926 2879657
SGTC_1354 1498-1681 81 µM -0.929929544093548 0.189647605243355 no 2699 0.176203782506406 924 5754243
SGTC_1361 1608-0041 5.61 µM -0.931425810553941 0.189264311039836 no 2700 0.175816672370021 900 X1361
SGTC_2659 sanguinarine 24.21 µM -0.9321622536833 0.189075833818564 no 2701 0.175626339703011 895 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_358 0075-0058 9.45 µM -0.932166086052544 0.189074853306234 no 2702 0.175625349574306 951 1069125
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.933692037535312 0.188684687267149 no 2703 0.175231386748281 930 689007
SGTC_1961 st076550 68.7 µM -0.934307392317449 0.188527489539584 no 2704 0.175072676101296 913 1579337
SGTC_631 k072-0230 41.5 µM -0.934816132926947 0.188397588329911 no 2705 0.174941531977518 937 5773147
SGTC_3201 9113999 49.47 µM -0.934889061425227 0.188378971381017 no 2706 0.174922737440132 925 16649224
SGTC_3230 9131665 49.47 µM -0.935941380871672 0.188110465045338 no 2707 0.174651684908279 897 15943720
SGTC_393 acivicin 6.25 µM -0.937110943531382 0.187812320623285 no 2708 0.174350746386791 893 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3218 9131285 49.47 µM -0.937361488976925 0.187748489658726 no 2709 0.174286321762335 923 17156417
SGTC_1509 1326-1131 80 µM -0.940069879110346 0.18705933410353 no 2710 0.173590858941358 877 768313
SGTC_2986 9022445 71.43 µM -0.941549424479653 0.186683522440511 no 2711 0.173211686841053 886 6459286
SGTC_1309 pyrazolanthrone 13.4 µM -0.943706450771466 0.186136465511309 no 2712 0.172659838333279 929 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2354 9060492 162 µM -0.945043927111755 0.185797759353078 no 2713 0.172318225168722 946 6471895
SGTC_1034 k072-0165 12.7 µM -0.945999280818264 0.185556057185831 no 2714 0.172074476522428 938 5835461
SGTC_1625 st003711 30.1 µM -0.946919426949154 0.185323447013557 no 2715 0.171839918894873 911 24207034 YER133W GLC7
SGTC_3068 9116768 49.47 µM -0.947787375519334 0.185104198240096 no 2716 0.171618854355528 903 41904888
SGTC_1561 5-methoxyflavone 52.9 µM -0.94854461274773 0.184913047449256 no 2717 0.171426136222232 895 94525
SGTC_205 1486-1330 71.903 µM -0.951503647022519 0.184167269834995 no 2718 0.170674384026174 925 4118834
SGTC_397 arbidol 50 µM -0.95170603620961 0.184116329347836 no 2719 0.170623043619743 913 131410 A RNA synthesis inhibitor.
SGTC_2167 5876490 200 µM -0.95220739514047 0.183990177242871 no 2720 0.170495905640811 904 686534
SGTC_2338 7999974 200 µM -0.952210747047001 0.183989334016161 no 2721 0.170495055845945 905 315925
SGTC_1115 galangin 695.678 nM -0.952482394654198 0.1839210046336 no 2722 0.170426195179539 925 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3069 9117009 49.47 µM -0.954124746200934 0.183508229369437 no 2723 0.170010250623919 899 41904981
SGTC_817 1391-0715 46 µM -0.956340528232595 0.182952248580343 no 2724 0.169450110241529 917 1353946
SGTC_745 0469-0705 296 µM -0.956375558897389 0.182943467186115 no 2725 0.169441264157063 925 3486736
SGTC_1350 1495-0454 146 µM -0.957119783242275 0.182756969155391 no 2726 0.169253399660499 901 1069057
SGTC_848 0368-0089 85.6 µM -0.957731546454942 0.182603753982867 no 2727 0.169099072492897 911 762535
SGTC_2949 9072542 2.23 µM -0.960025663876501 0.18202991045156 no 2728 0.168521149377102 946 16457352
SGTC_1351 1496-0003 46.5 µM -0.961156138782354 0.181747552068393 no 2729 0.168236833143606 925 3891978
SGTC_1970 st070122 35.8 µM -0.964309355349973 0.180961423173951 no 2730 0.167445425957819 920 102928
SGTC_911 3456-4043 236 µM -0.964639763555206 0.180879172570108 no 2731 0.16736263782281 914 914281
SGTC_1475 4092-1048 11.7 µM -0.968821471884722 0.179840219129462 no 2732 0.166317135742333 946 2881759
SGTC_2363 9053361 176 µM -0.96967813014079 0.179627844257959 no 2733 0.166103477455581 925 6469797 YMR079W SEC14
SGTC_382 3229-0966 23.2 µM -0.971054080138637 0.17928706134754 no 2734 0.165760674450747 930 5722370
SGTC_2032 5185112 25.99 µM -0.971762408217127 0.179111787652253 no 2735 0.165584380663124 893 5718189
SGTC_730 1436-0052 41.2 µM -0.972641870834589 0.178894317280811 no 2736 0.165365662489216 899 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2756 carbadox 75.1 µM -0.974786275836697 0.178364753447607 no 2737 0.164833143097581 900 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2533 agelasine 13.65 µM -0.976339901135977 0.177981701173688 no 2738 0.1644480264867 888 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2948 9070189 9.45 µM -0.976507358864344 0.177940444820075 no 2739 0.164406551485477 867 6473636 YDL196W YDL196W
SGTC_2397 5161689 200 µM -0.976978371174115 0.17782443444039 no 2740 0.164289930132972 935 2259942
SGTC_800 3448-7362 155 µM -0.97839519489092 0.177475758292822 no 2741 0.163939451912436 923 15991913
SGTC_2479 5617353 43.85 µM -0.979902866453599 0.177105199061543 no 2742 0.163567033949823 905 2731746
SGTC_1004 4084-0029 199 µM -0.980654052366483 0.176920753300255 no 2743 0.163381684731593 918 716894 YLR208W SEC13
SGTC_134 0269-0018 6.916 µM -0.980707235082411 0.176907699449576 no 2744 0.163368567488133 929 4378915
SGTC_1424 4048-1941 275 µM -0.981444075441296 0.176726902505623 no 2745 0.163186900004215 920 X1424
SGTC_973 1325-0077 65.9 µM -0.98188229063688 0.176619433994838 no 2746 0.163078920625845 929 2835149
SGTC_1693 xanthone 101.9 µM -0.98387564968952 0.176131101516737 no 2747 0.162588328840769 931 7020 An insecticide.
SGTC_3277 9138724 49.47 µM -0.98477798661071 0.175910328577499 no 2748 0.162366567935008 916 15943418
SGTC_2046 4110841 106 µM -0.984871849799084 0.175887373329456 no 2749 0.162343511159229 921 44119630 YMR134W ERG29
SGTC_1397 3532-0190 20.1 µM -0.985149697614939 0.175819433790334 no 2750 0.162275272456448 888 5322280
SGTC_2522 biochanin a 4.94 µM -0.985601123896564 0.175709086173328 no 2751 0.162164443154025 925 5280373 A possible chelator.
SGTC_1400 3771-8998 51.5 µM -0.985895900553725 0.175637054015043 no 2752 0.162092099381343 909 670767
SGTC_2025 5147754 141 µM -0.986345534375249 0.175527216723002 no 2753 0.161981791215845 873 315777 YLR208W SEC13
SGTC_2335 9018011 154.17 µM -0.988835800927414 0.174919678791291 no 2754 0.161371742491595 918 6458208
SGTC_2829 7992743 58.44 µM -0.990835759388766 0.174432726269975 no 2755 0.160882892480041 934 16462845
SGTC_1381 2324-0066 62.1 µM -0.991212377416419 0.174341123255452 no 2756 0.160790943983582 924 10885928
SGTC_262 fenpropimorph 62.5 µM -0.991463009217376 0.174280180213029 no 2757 0.160729773107862 961 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.991613476062777 0.174243599550475 no 2758 0.160693056463134 951 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_316 k060-0003 58.6 µM -0.992910934675945 0.173928371085015 no 2759 0.160376680253974 932 6152314
SGTC_1907 st060210 83.7 µM -0.993775801363617 0.173718446019285 no 2760 0.160166014806166 929 688793
SGTC_1750 st081859 2.357 µM -0.996340947054073 0.173096768607122 no 2761 0.159542257453124 920 5291695
SGTC_1695 st026914 34.495 µM -0.996572638352719 0.173040686787937 no 2762 0.159485996301459 936 3289191
SGTC_2101 5377231 179.231 µM -0.998836641801603 0.172493284855812 no 2763 0.158936916299429 950 2844213
SGTC_3040 9091894 49.47 µM -1.00004668876729 0.172201167097131 no 2764 0.158643956880337 885 25236966
SGTC_2717 st081029 62.2815 µM -1.00102575865224 0.171965040765994 no 2765 0.158407177665648 913 5292846
SGTC_281 1672-3440 14.9 µM -1.00174656407472 0.17179133332243 no 2766 0.158233005620852 934 6833000
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.00176842815193 0.171786066033727 no 2767 0.158227724452213 924 5282309
SGTC_786 4544-0069 423 µM -1.00413977003057 0.171215396874286 no 2768 0.157655624182248 918 748821 YLR208W SEC13
SGTC_1058 3448-5425 97.3 µM -1.0043471580348 0.171165546156405 no 2769 0.157605655300101 911 7279705
SGTC_1210 3013-0140 750 nM -1.00735453797389 0.170443693134278 no 2770 0.156882214995448 929 905973
SGTC_1665 st014639 11.4 µM -1.00781840060789 0.170332527276848 no 2771 0.156770825315748 918 981133 YIL048W NEO1
SGTC_1569 carminic acid 40.6 µM -1.00812202246095 0.170259788684113 no 2772 0.156697943255915 913 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2393 9031399 185.94 µM -1.00879274027852 0.170099175574213 no 2773 0.156537021729841 949 1526623 YDL150W RPC53
SGTC_3205 9113483 49.47 µM -1.00937549170051 0.169959706153494 no 2774 0.156397293851002 933 17018033
SGTC_2807 7945238 51.95 µM -1.01495383466544 0.168628357042136 no 2775 0.15506391712232 946 17148797
SGTC_1489 4065-0444 182 µM -1.01549181939844 0.168500314879682 no 2776 0.154935722069353 897 2877968
SGTC_2740 felodipine 17.08 µM -1.02147763397126 0.167079889787467 no 2777 0.153514100194266 919 3333 L-type calcium channel blocker
SGTC_2444 5485484 36.41 µM -1.02226480266149 0.166893671883986 no 2778 0.15332779360504 967 6790631
SGTC_1906 st060206 94.7 µM -1.0228750352813 0.16674940332006 no 2779 0.153183467251931 920 5133468
SGTC_449 xestospongin c 11.1929 µM -1.02290008860492 0.16674348204146 no 2780 0.153177543805286 928 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3076 9116187 49.47 µM -1.0230446922505 0.1667093080509 no 2781 0.153143357616292 921 27241210
SGTC_994 3910-0338 138 µM -1.02380382630655 0.166529977039463 no 2782 0.152963971376677 936 3479481
SGTC_2246 7293507 91.5585 µM -1.02432090542453 0.166407898235789 no 2783 0.152841863425598 931 887656
SGTC_742 0kpi-0133 140 µM -1.0269811389816 0.165780749108275 no 2784 0.152214672705119 946 2728852
SGTC_826 1683-5028 118 µM -1.02751504798497 0.165655064595657 no 2785 0.152089001682185 940 722377
SGTC_3284 9108171 64.8615 µM -1.02860619327852 0.165398395915854 no 2786 0.151832383245015 910 8687505
SGTC_702 1488-0190 94 µM -1.02905131714696 0.165293763939665 no 2787 0.15172778050327 920 949357
SGTC_1759 st043059 70 µM -1.02930231072036 0.165234783626109 no 2788 0.151668818905627 951 669426
SGTC_1273 0849-0096 14.1 µM -1.03409089041985 0.164112137271068 no 2789 0.150546837264554 947 5286025
SGTC_2398 5228213 48.84 µM -1.03472718384969 0.163963336335402 no 2790 0.150398168575831 951 80771 YMR134W ERG29
SGTC_2369 9071472 200 µM -1.03518168641788 0.163857101868403 no 2791 0.150292034868388 938 17296037
SGTC_466 geldanamycin 89.2 µM -1.03540840865625 0.163804124995689 no 2792 0.1502391102187 917 5288382 HSP90 inhibitor.
SGTC_1758 st042942 75.2445 µM -1.03572284224901 0.163730671520466 no 2793 0.150165731329086 926 669317
SGTC_3265 9137266 49.47 µM -1.03706934506618 0.163416362674985 no 2794 0.149851770243999 905 17224265
SGTC_2476 5806916 10.51 µM -1.03713585023291 0.163400848799228 no 2795 0.149836274735501 915 2870194
SGTC_778 3456-2434 196 µM -1.03803435273051 0.163191345986115 no 2796 0.149627031049616 859 5539063
SGTC_372 0155-0182 15.9 µM -1.04334319791836 0.161957052888199 no 2797 0.148394685463961 849 771486
SGTC_2748 diazoxide 86.69 µM -1.04373495090746 0.161866212873456 no 2798 0.14830401731931 869 3019 A potassium channel activatior.
SGTC_86 0417-1630 471.922 µM -1.04656133354145 0.161211812820628 no 2799 0.147650971607408 929 3634867
SGTC_1523 st012844 44.7 µM -1.04751739040035 0.160990845582957 no 2800 0.147430507887711 954 4274103
SGTC_2008 4012253 172 µM -1.04907204704546 0.160631950124114 no 2801 0.147072480114807 918 603940
SGTC_1773 st048542 73.5835 µM -1.04976720585726 0.160471640584374 no 2802 0.146912578132283 940 3237138
SGTC_1971 st069429 63.5 µM -1.0499348573844 0.160432994364528 no 2803 0.146874032011968 923 1246522 YGL099W LSG1
SGTC_63 0099-0242 26.702 µM -1.05027826936321 0.16035385168235 no 2804 0.146795096564254 936 3898502 YLR359W ADE13
SGTC_2848 9016370 25.97 µM -1.05174860840752 0.160015286049925 no 2805 0.146457451530575 900 7894410
SGTC_3190 9110366 49.47 µM -1.05248194400219 0.159846600359523 no 2806 0.146289245159247 934 17123768
SGTC_1142 3253-1408 9.78 µM -1.06045390195918 0.158020357270027 no 2807 0.144469075590032 959 256655
SGTC_444 curcumin 90.4 µM -1.0612651053168 0.157835294932841 no 2808 0.144284719566439 932 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3260 9137109 49.47 µM -1.06317054054938 0.157401162130089 no 2809 0.143852309716785 927 17478346
SGTC_185 k048-0037 25.491 µM -1.06530978869469 0.156914693715144 no 2810 0.143367882285055 937 6827589
SGTC_1520 flindersine 88 µM -1.06689284064782 0.156555342705944 no 2811 0.143010114062667 938 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2295 7971645 200 µM -1.06754808418927 0.156406761829592 no 2812 0.142862206323242 975 2978226 YKL099C UTP11
SGTC_519 k048-0011 62.8 µM -1.06813813495967 0.156273043344785 no 2813 0.142729103012364 928 6836379
SGTC_3318 9139014 38.6185 µM -1.06874432820781 0.156135745069123 no 2814 0.142592445626166 939 16643984
SGTC_939 1165-0479 45.3 µM -1.07021804282768 0.155802291232478 no 2815 0.142260587375669 927 1377347
SGTC_327 1273-0057 3.96 µM -1.07094245980944 0.15563855141797 no 2816 0.14209765135688 925 3108138
SGTC_2678 equilin 100 µM -1.07234456321458 0.155321956825864 no 2817 0.141782648914812 896 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2093 5331342 194.4 µM -1.07445430697945 0.154846378681187 no 2818 0.14130955680634 938 33839
SGTC_1606 st000094 49.2 µM -1.07446467307237 0.154844044335228 no 2819 0.141307234942942 931 1242210
SGTC_2827 7993847 71.43 µM -1.07495637159626 0.154733345186421 no 2820 0.141197130886387 919 2985692
SGTC_1916 st067606 49.2 µM -1.08236457206186 0.153071820679221 no 2821 0.139545282010189 905 19590279
SGTC_2746 daunorubicin 9.88 µM -1.08342313847542 0.152835372763699 no 2822 0.139310324954508 925 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2978 9011784 42.97 µM -1.08410846154888 0.152682424010283 no 2823 0.139158355782774 920 2994934
SGTC_3100 9120536 49.47 µM -1.08451985382887 0.152590659256715 no 2824 0.139067184489247 938 16421196
SGTC_2278 7948257 134.34 µM -1.087409169632 0.151947202463982 no 2825 0.138428010260566 938 1247028
SGTC_328 k915-0120 63.5 µM -1.08933201135395 0.151519981863193 no 2826 0.13800375060694 949 6624543
SGTC_1421 4029-0249 71.4 µM -1.08966090690476 0.151446987287543 no 2827 0.137931271348819 951 2894095
SGTC_2048 5246248 200 µM -1.09035305964227 0.151293448360526 no 2828 0.137778825337541 937 677046
SGTC_2741 miltefosine 3.04 µM -1.0919044265877 0.15094968778715 no 2829 0.137437555921937 923 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1279 0874-0590 65.2 µM -1.09267652383703 0.150778796051257 no 2830 0.137267925387823 952 3523074
SGTC_536 3852-0578 10.6 µM -1.09339155597036 0.150620649715628 no 2831 0.137110959697554 963 2869208
SGTC_874 0599-0792 117 µM -1.09381660390479 0.15052669264238 no 2832 0.137017710218132 955 765305
SGTC_3336 9143619 71.43 µM -1.09729539970153 0.149759170524062 no 2833 0.136256140616628 970 45595730
SGTC_699 0375-0592 111 µM -1.09761244197196 0.149689351940938 no 2834 0.136186878782274 908 762578
SGTC_2953 9074162 66.49 µM -1.09767796291602 0.14967492572305 no 2835 0.13617256792041 908 16451992
SGTC_443 clozapine 122 µM -1.09987258554436 0.149192255736013 no 2836 0.135693820408135 979 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_290 2043-6722 48.1 µM -1.10040058460797 0.149076286601611 no 2837 0.13557881194403 943 773758 YLR208W SEC13
SGTC_1851 st056236 18.9 µM -1.10057044660813 0.149038991103251 no 2838 0.135541826899626 913 5393171
SGTC_2096 5468907 200 µM -1.102968601031 0.148513109074598 no 2839 0.135020400461482 949 759785
SGTC_659 k018-0002 107 µM -1.10318525456493 0.148465661142591 no 2840 0.134973361718888 964 6797879 YHR007C ERG11
SGTC_3061 glucosamine 200 µM -1.10561451994916 0.14793433708403 no 2841 0.134446701210187 923 91431 and experimental redox chemotherapeutic
SGTC_2629 bisabolol 100 µM -1.10581948592555 0.147889565638574 no 2842 0.134402329574988 955 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2825 7998094 58.44 µM -1.10626701395561 0.147791842032074 no 2843 0.134305482343289 950 2987815
SGTC_935 2996-0153 430 µM -1.10807101291196 0.147398353760292 no 2844 0.133915574267842 953 23738523
SGTC_3071 9117417 49.47 µM -1.11072532358858 0.146820672932769 no 2845 0.133343299262456 954 45595590 YGL055W OLE1
SGTC_2382 9035899 200 µM -1.11100447308606 0.146760007572744 no 2846 0.133283211961062 967 6462679
SGTC_2983 9022671 12.99 µM -1.11168190187559 0.146612857248498 no 2847 0.133137471981698 942 6405161
SGTC_366 0181-0206 4.31 µM -1.11184527462083 0.146577384427558 no 2848 0.133102340884452 977 274874
SGTC_1200 1643-0193 18.4 µM -1.11211676982405 0.146518447918899 no 2849 0.133043973628773 950 5403974
SGTC_1634 st006576 41 µM -1.11402498682543 0.146104658676191 no 2850 0.132634233678485 949 3915356
SGTC_1871 st057448 67.3 µM -1.11591926309298 0.145694669571864 no 2851 0.132228347727537 970 691747
SGTC_2588 indole-3-carbinol 100 µM -1.11638995174638 0.145592915804977 no 2852 0.132127626381123 959 3712 Induces cell cycle arrest.
SGTC_1188 1403-0014 4.57 µM -1.1168413775291 0.145495371198835 no 2853 0.13203107675103 932 9614867
SGTC_1738 st035555 74 µM -1.11687119783988 0.145488929139469 no 2854 0.132024700583512 960 5331140
SGTC_1224 0823-0416 294 µM -1.11742980498025 0.145368289111428 no 2855 0.131905298663102 952 3598164
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.12008470746037 0.144795841125779 no 2856 0.131338833352573 964 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1878 temozolomide 1 mM -1.12296479934593 0.144176556828684 no 2857 0.130726222354721 935 5394 DNA alkylating agent.
SGTC_250 brefeldin a 552.239 µM -1.12400703943521 0.143952892531813 no 2858 0.130505019808421 961 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_283 0987-0079 11.7 µM -1.12422180045883 0.143906833999974 no 2859 0.130459471624878 964 411556
SGTC_3257 9139206 32.98 µM -1.12571754352111 0.143586326520596 no 2860 0.130142547781257 958 4910041
SGTC_2977 9011197 71.43 µM -1.12596788842172 0.143532729777943 no 2861 0.130089555825361 926 2704722
SGTC_2884 9058502 51.95 µM -1.12758904720317 0.143185980190358 no 2862 0.129746757223451 960 6471554
SGTC_1141 3253-0389 52.6 µM -1.1307266614974 0.142516484459435 no 2863 0.129085078013887 966 5402031
SGTC_167 3672-0051 66.205 µM -1.13189203991577 0.142268359203796 no 2864 0.128839912832032 945 3237971
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.13381777575013 0.141858984218046 no 2865 0.128435496523209 928 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3237 9133362 49.47 µM -1.13445555077397 0.1417235813274 no 2866 0.128301754321363 970 43845137
SGTC_2115 tiliquinol 12.7705 µM -1.1354860218104 0.141504992105423 no 2867 0.128085867686722 955 71208 A bioactive hydroxyquinoline.
SGTC_485 niflumic acid 177 µM -1.13566359606619 0.141467347159034 no 2868 0.128048690873823 982 4488 A COX2 inhibitor.
SGTC_2744 captopril 92.04 µM -1.13575794895056 0.141447347531658 no 2869 0.12802894027463 960 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_446 go6976 132 µM -1.13652459567659 0.141284915333116 no 2870 0.127868538929421 975 3501 A protein kinase C inhibitor.
SGTC_1454 4239-0054 42.6 µM -1.13917617756945 0.140724090388199 no 2871 0.127314839782276 954 1340767
SGTC_3042 9091578 49.47 µM -1.13958456509106 0.140637848497019 no 2872 0.127229709383427 945 25236497
SGTC_3039 9090270 49.47 µM -1.14338114995633 0.139837815494955 no 2873 0.126440187687658 939 17173750
SGTC_2127 5253358 187.912 µM -1.14688432803771 0.139102359611404 no 2874 0.125714715316036 961 20612
SGTC_791 1348-1292 225 µM -1.14692826306869 0.13909315265532 no 2875 0.125705635295852 983 5437054
SGTC_439 amiodarone 34.4 µM -1.15137709601883 0.138163009309082 no 2876 0.124788566150706 956 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_937 3122-0005 46.7 µM -1.15250143104421 0.137928610971934 no 2877 0.124557541018528 958 759535
SGTC_2859 9028643 45.46 µM -1.15408124764392 0.137599713664626 no 2878 0.124233430330369 924 17151580
SGTC_1877 wortmannin 25 µM -1.15427057687553 0.137560333727383 no 2879 0.124194627704753 967 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3095 9117207 49.47 µM -1.15549694945587 0.137305438064168 no 2880 0.123943490554824 962 17015229
SGTC_1383 3049-0032 20.7 µM -1.15680173140847 0.137034599751693 no 2881 0.12367668715374 963 712864
SGTC_1132 3456-3614 2.5 µM -1.15731461738965 0.13692823816441 no 2882 0.123571921789581 974 3125502
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.16027729583363 0.136314946351858 no 2883 0.122967962632136 971 4213774
SGTC_468 gf-109203x 121 µM -1.16174422542717 0.136011980029736 no 2884 0.122669687808543 984 2396 A protein kinase C inhibitor.
SGTC_1217 1183-1422 255 µM -1.16248001479425 0.135860190495718 no 2885 0.122520269012261 952 2849664
SGTC_357 1325-0123 420 µM -1.16434994034472 0.135474956686994 no 2886 0.122141112830317 990 1098503
SGTC_1630 st005209 31.3 µM -1.16478312793073 0.135385820185786 no 2887 0.122053395041003 943 3367314
SGTC_35 0133-0054 64.071 µM -1.16547910600725 0.13524269377852 no 2888 0.121912556466235 965 99677
SGTC_1976 st070609 63.5 µM -1.16632587500994 0.135068697461338 no 2889 0.12174135772652 952 682556
SGTC_2094 5332512 191.667 µM -1.16778815065806 0.134768586806962 no 2890 0.1214461144662 973 755774
SGTC_3064 1327-0027 10 µM -1.16832567095022 0.134658383735291 no 2891 0.121337712144151 933 16000455 YPR107C YTH1
SGTC_1727 st034309 9.9045 µM -1.16918947242176 0.134481415676728 no 2892 0.121163650883219 989 870305
SGTC_649 1123-0311 367 µM -1.17057455885596 0.134197984730005 no 2893 0.120884914253902 953 693629 YIL048W NEO1
SGTC_3090 9117696 49.47 µM -1.17228350696959 0.133848847598902 no 2894 0.120541625533166 937 7923821
SGTC_2504 purpurogallin 52.29 µM -1.17242900150457 0.133819152013165 no 2895 0.120512430739351 962 5281571 An antioxidant.
SGTC_155 k072-0202 43.6 µM -1.17430313197914 0.133437044874423 no 2896 0.120136814627548 949 5857737
SGTC_2738 aclarubicin 5.55 µM -1.17648557060114 0.132993024975808 no 2897 0.119700447569023 967 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2129 girgensonine 121.053 µM -1.17857294250846 0.132569299143553 no 2898 0.119284135537432 972 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_70 0141-0289 43.283 µM -1.17875302522765 0.132532786902402 no 2899 0.11924826721405 942 352408
SGTC_1615 st002656 86.5 µM -1.17966768065574 0.13234744509642 no 2900 0.119066206474498 983 1584458
SGTC_1254 0550-0035 264 µM -1.18016726569626 0.132246286821937 no 2901 0.11896684775963 979 15121435
SGTC_1641 st009299 47.1 µM -1.1803437149214 0.132210571312425 no 2902 0.118931769094493 948 4046054
SGTC_1984 st072354 53.1 µM -1.18288782517591 0.131696350949765 no 2903 0.118426803689385 953 5762938
SGTC_214 4373-3496 70 µM -1.18549030217096 0.131171763071312 no 2904 0.117911823376792 983 3779166
SGTC_2768 sulfasalazine 50.2 µM -1.18570143702375 0.131129267470053 no 2905 0.117870113426077 990 5384001 An antioxidant and salicylic acid derivative.
SGTC_139 0099-0334 718.624 µM -1.18633782627315 0.131001237465884 no 2906 0.117744457101974 977 97690
SGTC_1610 st001799 48.1 µM -1.18687780739141 0.130892670788146 no 2907 0.117637911126239 972 621897
SGTC_886 0866-0150 153 µM -1.18857872931279 0.130551095966665 no 2908 0.117302741085842 972 271463
SGTC_3246 9135460 32.98 µM -1.18864492797037 0.130537814593215 no 2909 0.117289710196896 967 41446951
SGTC_3155 9099265 49.47 µM -1.19007050609933 0.130252028910754 no 2910 0.117009340710562 978 25236499
SGTC_2610 ononetin 44.17 µM -1.19069519398811 0.130126934221171 no 2911 0.116886632660676 995 259632
SGTC_1530 rhein 70.4 µM -1.19242764543308 0.129780443328268 no 2912 0.116546802856781 969 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3287 9117173 37.0625 µM -1.19262312581215 0.129741387332835 no 2913 0.116508502351785 932 2789709
SGTC_1751 st044839 27.194 µM -1.19486424673015 0.129294204208135 no 2914 0.116070036913351 964 5291326
SGTC_570 0987-0065 62.6 µM -1.19573612235758 0.129120523066625 no 2915 0.115899775156433 923 3104428
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.19584710930732 0.129098425629982 no 2916 0.115878114115523 983 94937 An inhibitor of serotonin biosynthesis.
SGTC_2463 5473429 200 µM -1.19897922887909 0.128475903344529 no 2917 0.115268011155903 956 5399405
SGTC_2557 derrustone 83.84 µM -1.1996429251493 0.128344258837588 no 2918 0.115139024034466 978 629853 An antioxidant.
SGTC_3142 9086498 49.47 µM -1.20261424949352 0.12775604341904 no 2919 0.114562815446189 934 25236367
SGTC_2638 epoxomicin 18 µM -1.20349837260897 0.127581381100194 no 2920 0.114391760374486 962 9915668 A protesome inhibitor.
SGTC_3238 9133470 49.47 µM -1.20421987159796 0.127438968952022 no 2921 0.114252303688189 947 3534688
SGTC_1996 st072960 66.8 µM -1.20460420787561 0.12736315237778 no 2922 0.114178065759993 960 1719405
SGTC_2860 9025725 38.96 µM -1.20507545388301 0.12727023427049 no 2923 0.114087087349748 991 40546248
SGTC_464 bw-b 70c 158 µM -1.20754674663112 0.126783728338062 no 2924 0.113610826827653 981 5353454
SGTC_2248 tofa 1.1 µM -1.20767479394385 0.126758555901044 no 2925 0.113586188595055 938 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2640 pentamidine 10.38 µM -1.20918796168745 0.126461350330566 no 2926 0.113295320789034 935 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2415 st077333 57.7 µM -1.21091259542961 0.126123202518038 no 2927 0.11296445240349 939 2766255
SGTC_458 nppb 133 µM -1.21188222253573 0.125933365410799 no 2928 0.112778734065376 991 4549 A chloride channel blocker.
SGTC_1700 st030840 7.9285 µM -1.21358069614364 0.125601312498596 no 2929 0.112453941091419 980 5499307
SGTC_692 k241-0027 77.8 µM -1.21366745847751 0.125584366810841 no 2930 0.1124373678016 962 3600480
SGTC_2469 5655019 90.81 µM -1.21385832489935 0.125547094005242 no 2931 0.112400914752369 980 2788239
SGTC_1246 0422-0085 105 µM -1.21569357966996 0.12518909546114 no 2932 0.112050835411549 968 264295
SGTC_1794 st048918 76.9 µM -1.21786728153706 0.124765999798301 no 2933 0.11163720569221 902 672303
SGTC_1671 st016596 74.5 µM -1.22006594781159 0.124339062559014 no 2934 0.111219937994203 986 2829167
SGTC_2995 9067767 71.4286 µM -1.22090985714079 0.124175463817761 no 2935 0.111060075956287 972 11673567
SGTC_2523 spermine 47.74 µM -1.22609962188198 0.123172695844478 no 2936 0.11008059406786 957 1103 A DNA binding polyamine.
SGTC_2239 6685329 187.64 µM -1.22667022718696 0.123062790589446 no 2937 0.109973281130094 952 805680
SGTC_1687 st020778 55.3625 µM -1.2276289366345 0.122878286750574 no 2938 0.10979314704468 982 4259299
SGTC_2524 avocatin b 10.57 µM -1.22907647569903 0.122600075229051 no 2939 0.10952156710789 972 6710748
SGTC_3021 9087658 49.47 µM -1.23169063557004 0.12209876391108 no 2940 0.10903233461701 965 25237042
SGTC_2021 4019055 173 µM -1.23199507637428 0.122040475721924 no 2941 0.108975461673248 981 44827708 YER133W GLC7
SGTC_3330 9141424 71.43 µM -1.23557714709165 0.121356120371698 no 2942 0.108307891851885 969 27261020
SGTC_2077 5212015 200 µM -1.23605314026338 0.121265385283158 no 2943 0.108219405754664 958 780900
SGTC_694 1315-0438 43.2 µM -1.23630231229207 0.121217906474833 no 2944 0.108173105969598 965 6793154
SGTC_2967 9089538 49.85 µM -1.23815082234904 0.12086608796881 no 2945 0.10783007114485 985 728216
SGTC_2919 7978188 46.38 µM -1.23938949501287 0.120630739511204 no 2946 0.107600644946761 949 2980291
SGTC_2151 5563267 85.4165 µM -1.23987681607717 0.120538236747349 no 2947 0.107510480114265 1008 5310824
SGTC_1746 st038117 42 µM -1.24257349094085 0.120027259769263 no 2948 0.107012521758372 979 2898218
SGTC_2650 prasterone 100 µM -1.24293969492324 0.11995798785567 no 2949 0.106945028345752 974 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_671 0560-0003 407 µM -1.24350584295403 0.119850949576953 no 2950 0.106840744587337 980 3238678
SGTC_1583 clindamycin 39.6 µM -1.24708903515908 0.1191750582083 no 2951 0.106182426476875 995 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2156 5649887 115 µM -1.25337357028308 0.117996124010323 no 2952 0.10503489268403 1004 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1136 pergolide 1.05886 µM -1.25382102374086 0.1179125006331 no 2953 0.104953532915449 987 47811 A dopamine receptor agonist.
SGTC_2910 7948405 25.97 µM -1.25394755313949 0.117888861499362 no 2954 0.10493053454774 941 2971328
SGTC_1795 st049545 62.3 µM -1.25502603726277 0.117687507413119 no 2955 0.104734654067304 932 5291882
SGTC_2329 6138490 200 µM -1.25505856174276 0.117681438842899 no 2956 0.104728750900719 999 720019
SGTC_3269 9137823 49.47 µM -1.25803009031903 0.117127931301531 no 2957 0.104190437117845 948 17682936
SGTC_1035 k081-0041 55.2 µM -1.2612894000653 0.116522942570902 no 2958 0.103602299415968 974 731709
SGTC_1969 st069479 40.1 µM -1.26174926126355 0.116437762484835 no 2959 0.103519512447596 981 3895485
SGTC_50 0929-0078 56.389 µM -1.26267696437964 0.116266058499343 no 2960 0.103352647918437 949 1377751
SGTC_3014 9081533 49.47 µM -1.26509503791099 0.115819353906787 no 2961 0.102918630728662 996 21367265
SGTC_1979 st071809 45.3 µM -1.26770455139816 0.115338652365703 no 2962 0.102451739414912 994 4976333
SGTC_1666 st014829 29 µM -1.26936748590697 0.11503306197542 no 2963 0.10215501351441 1000 3858230
SGTC_2443 5493264 126.67 µM -1.2706382739969 0.114799923099395 no 2964 0.101928682095429 1006 5340055
SGTC_3111 9122088 49.47 µM -1.27064090510791 0.11479944074455 no 2965 0.101928213865042 962 16876704
SGTC_2200 6600604 21.907 µM -1.27137255657563 0.114665364897306 no 2966 0.101798070495009 1004 2904777
SGTC_1788 fluconazole 20 µM -1.27189017440252 0.114570578250001 no 2967 0.101706071698745 981 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_629 3448-6466 76.7 µM -1.27480862170845 0.114037193085898 no 2968 0.101188494157609 1000 573744
SGTC_1009 4106-0057 9.87 µM -1.27687688224412 0.113660263502353 no 2969 0.100822858477959 986 2928005
SGTC_487 nimodipine 119 µM -1.27818100946421 0.113423050230674 no 2970 0.100592805250246 1005 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1668 st014914 51.6 µM -1.27898634107914 0.113276741474884 no 2971 0.100450932928114 997 2839556
SGTC_3262 9137218 49.47 µM -1.2796221502957 0.113161325870952 no 2972 0.100339027922708 960 17650664
SGTC_1891 st059073 26.2 µM -1.28070242481249 0.112965420901116 no 2973 0.100149103878168 988 688754
SGTC_3199 9111318 49.47 µM -1.28218696899455 0.112696597762433 no 2974 0.0998885331519451 962 8548020
SGTC_859 0439-0102 54.6 µM -1.28452624815957 0.112273925724989 no 2975 0.0994789427528731 979 610143
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.28620699806379 0.111970940064067 no 2976 0.0991854147015181 983 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2586 curcumin 80 µM -1.28743813183664 0.111749377130432 no 2977 0.098970810342618 1004 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3034 9090421 49.47 µM -1.28845781619355 0.111566105597426 no 2978 0.0987933220041776 969 17173761
SGTC_3119 9125183 49.47 µM -1.2911386596779 0.111085294225597 no 2979 0.0983278003214033 968 22695334
SGTC_2187 6125751 200 µM -1.29231912788287 0.110874047573652 no 2980 0.0981233252310011 1009 874498
SGTC_1855 st056195 39.6 µM -1.29382143696594 0.110605623380894 no 2981 0.0978635531215621 951 4028379
SGTC_465 cgp-37157 41 µM -1.29597089503037 0.110222380669714 no 2982 0.0974927561809028 982 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2691 st077356 60.2 µM -1.29670925079439 0.110090953811836 no 2983 0.0973656225858079 998 2839272
SGTC_1997 st073024 93.8 µM -1.30005213487614 0.109497329293937 no 2984 0.0967915506080488 996 686268
SGTC_1755 st041960 45.185 µM -1.30055013842302 0.109409091651813 no 2985 0.0967062418476567 1002 2257073
SGTC_1314 1222-0010 41.1 µM -1.30201213975656 0.109150345304006 no 2986 0.0964561178515031 1006 3526027
SGTC_2747 doxorubicin 7.63 µM -1.30670984797148 0.108321917711751 no 2987 0.0956556363964401 940 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_183 3914-0051 30.55 µM -1.30672624124912 0.108319034747908 no 2988 0.0956528515943891 991 1596232
SGTC_734 2023-0417 80 µM -1.30694515772026 0.108280540828074 no 2989 0.0956156689560062 1000 3935732
SGTC_3195 9113082 49.47 µM -1.30781949064468 0.108126897718709 no 2990 0.0954672708686647 1007 17018038
SGTC_1678 st019265 80.2 µM -1.30806009654895 0.108084644533307 no 2991 0.0954264632596424 988 5367020
SGTC_1276 0871-0068 94.2 µM -1.30965760695489 0.107804404648459 no 2992 0.0951558454589606 989 3414906
SGTC_3162 9099653 49.47 µM -1.31121552089312 0.107531615331677 no 2993 0.0948924800299779 979 25237511
SGTC_3299 9121982 43.1275 µM -1.31137179242329 0.107504279804441 no 2994 0.0948660919864013 991 17594604 YPL160W CDC60
SGTC_2407 paclitaxel 400 µM -1.3129632265411 0.107226186093775 no 2995 0.0945976699227527 1010 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2757 clomiphene 4.22 µM -1.31521939232952 0.106832823938631 no 2996 0.0942180897877852 1013 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2341 7987486 176.74 µM -1.31590313227131 0.10671381982706 no 2997 0.0941032786604884 975 1258686
SGTC_73 0327-0325 16.231 µM -1.31834420845545 0.106289733993681 no 2998 0.093694224099602 930 53298
SGTC_1494 4358-1428 177 µM -1.31949319688389 0.106090543166891 no 2999 0.0935021415083771 983 1564571
SGTC_669 0108-0021 26.2 µM -1.31959393657103 0.106073091610629 no 3000 0.0934853141894953 991 17201
SGTC_1432 4049-0298 68.4 µM -1.31966819440888 0.106060228943582 no 3001 0.0934729117681313 1013 741646
SGTC_2084 5306078 60.6385 µM -1.31968836263611 0.106056735672732 no 3002 0.0934695435140142 1002 679340
SGTC_642 0335-0876 158 µM -1.32009838489647 0.1059857351189 no 3003 0.0934010859763658 1002 6812350
SGTC_3177 9107506 49.47 µM -1.32444224452781 0.105235649406982 no 3004 0.0926781062285282 993 8897194
SGTC_2543 pimpinellin 60.67 µM -1.3257684297991 0.105007414572409 no 3005 0.0924582065737138 988 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_478 N-arachidonylglycine 10 µM -1.32713556367448 0.104772507827146 no 3006 0.092231921443598 1004 5283389
SGTC_2331 7980721 200 µM -1.32789102983125 0.104642863783109 no 3007 0.092107054253495 977 2981221
SGTC_3261 9137475 49.47 µM -1.33329473450429 0.103718931626646 no 3008 0.0912175504856059 951 17027690
SGTC_2754 granisetron 64.02 µM -1.33337504782708 0.103705244333547 no 3009 0.0912043783188948 1011 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2752 diclazuril 33.15 µM -1.33374344790264 0.103642477024026 no 3010 0.0911439751935989 969 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2121 5257820 149.641 µM -1.33487585814285 0.103449711705192 no 3011 0.0909584902004075 993 791256
SGTC_1903 st060211 78.3 µM -1.33720689468693 0.103053728844301 no 3012 0.0905775559911434 979 688960
SGTC_3048 9093155 49.47 µM -1.33803776614108 0.102912851743389 no 3013 0.0904420630106061 976 25236002
SGTC_2130 NSC 7 2.4545 µM -1.33810348800736 0.102901714350127 no 3014 0.0904313519527147 1011 21448
SGTC_1973 st070275 50.2 µM -1.33821360509422 0.102883055593623 no 3015 0.0904134076701338 999 17118334
SGTC_793 0488-0545 106 µM -1.33863870601385 0.102811047558822 no 3016 0.0903441595648266 1000 292548
SGTC_227 fluconazole 33.516 µM -1.33987987543509 0.102601014889108 no 3017 0.0901422008913616 999 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1908 st060353 56.5 µM -1.34176934505244 0.102281874927111 no 3018 0.0898353973198238 1000 4227716
SGTC_1825 st052143 62.6 µM -1.34180672512401 0.102275568555348 no 3019 0.0898293355511493 1001 674173
SGTC_606 k015-0008 38.6 µM -1.34368123950811 0.101959682837665 no 3020 0.0895257432177039 1024 1970475
SGTC_83 0170-0301 39.027 µM -1.34621749276659 0.101533414565478 no 3021 0.0891161926177937 1020 3089716
SGTC_940 3232-1287 54.8 µM -1.347529634338 0.101313392935621 no 3022 0.0889048579044388 1001 1585493 YIL048W NEO1
SGTC_1799 st045822 46.1415 µM -1.3536144184519 0.100297628000222 no 3023 0.087929712234227 960 3674992
SGTC_3073 9114972 49.47 µM -1.35650906556208 0.0998170268183288 no 3024 0.0874686264619575 998 41905075
SGTC_1499 4480-0877 67.3 µM -1.35854712305884 0.0994796566807899 no 3025 0.0871450702777337 978 2861909
SGTC_588 3970-1144 52.9 µM -1.36216356898814 0.0988830606816074 no 3026 0.0865731351158274 988 1888707
SGTC_3342 9147791 14.508 µM -1.36553429900997 0.0983293607646624 no 3027 0.0860425902431235 988 1838168
SGTC_1420 4'-methoxyflavone 42 µM -1.36787451684265 0.0979462777892241 no 3028 0.0856756788106849 1000 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2828 7998861 71.43 µM -1.3704674459281 0.0975231057226092 no 3029 0.0852705153629355 971 2988188
SGTC_39 0986-0283 58.349 µM -1.37264623837122 0.0971685597230486 no 3030 0.0849311749971307 987 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3107 9121808 49.47 µM -1.37388090538508 0.0969680677590554 no 3031 0.0847393292416217 942 662681
SGTC_2525 harmine 47.85 µM -1.37396146765418 0.0969549961806331 no 3032 0.0847268225707931 983 5280953 A monoamine oxidase inhibitor
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.37432810063435 0.0968955247247631 no 3033 0.0846699231124573 994 2724278 An inhibitor of dopamine biosynthesis.
SGTC_64 000l-0018 272.079 µM -1.37631274079136 0.0965740615237447 no 3034 0.0843624150276754 982 6811119
SGTC_622 1348-1566 26.3 µM -1.38042938193459 0.095909765562143 no 3035 0.0837272393844356 1002 7340407
SGTC_2918 7977171 22.06 µM -1.38157167508981 0.0957260325285979 no 3036 0.0835516280287778 986 2236483
SGTC_3024 9090631 49.47 µM -1.38354617385098 0.0954090536108026 no 3037 0.0832487297976115 992 25236383
SGTC_1875 nocodazole 6 µM -1.38374165638147 0.0953777136325641 no 3038 0.0832187867476289 1010 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_294 k038-0071 157 µM -1.39697593736643 0.0932735644261142 no 3039 0.0812104036052058 1015 24152826
SGTC_1426 4048-4480 71.7 µM -1.40039613221911 0.0927353990504669 no 3040 0.0806973638057989 1008 14224343
SGTC_3202 9113761 49.47 µM -1.40044191535165 0.0927282107133762 no 3041 0.0806905128341824 1003 4798415
SGTC_3214 9129694 49.47 µM -1.40094161962149 0.0926497797302485 no 3042 0.0806157658230842 1024 17158655
SGTC_1334 1486-0610 236 µM -1.40353294840844 0.0922438450983665 no 3043 0.080228986964408 986 3742339
SGTC_1642 st009582 77.7 µM -1.40371248503604 0.0922157693200792 no 3044 0.0802022415684927 1002 6739311
SGTC_3354 9151612 71.43 µM -1.40508281607855 0.0920016865265763 no 3045 0.0799983266605441 994 27261949
SGTC_1453 4237-0541 195 µM -1.40688261852901 0.091721068082469 no 3046 0.0797310992325495 977 739892
SGTC_1828 st055811 49 µM -1.41030005523971 0.0911899801769876 no 3047 0.0792255511171222 1009 5877589
SGTC_2819 7996655 46.38 µM -1.41195427766375 0.0909337257251892 no 3048 0.0789817121631049 992 6456960
SGTC_933 2914-0560 114 µM -1.41487809932628 0.0904821057512927 no 3049 0.0785521201337752 1000 463887
SGTC_2934 9036370 36.88 µM -1.41779343953847 0.0900334560132863 no 3050 0.0781255400495674 986 6462800
SGTC_2641 levomentholum 100 µM -1.41878204430702 0.089881692813908 no 3051 0.077981284543793 1014 16666
SGTC_3125 9127534 49.47 µM -1.41907865271323 0.0898361968132642 no 3052 0.0779380433943723 1001 1639235
SGTC_2027 5150920 200 µM -1.41933798910713 0.0897964318984715 no 3053 0.0779002508676362 974 786715
SGTC_186 3455-3465 67.277 µM -1.42011093290702 0.0896779914580763 no 3054 0.0777876939462525 1010 755278
SGTC_2490 carminic acid 95.39 µM -1.42692332895581 0.0886391270479789 no 3055 0.076800997815483 1004 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2771 fluoxetine 41.05 µM -1.430095430256 0.0881584635980551 no 3056 0.0763448157951456 1005 3386 A selective serotonin reuptake inhibitor.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.43014090966907 0.088151586331777 no 3057 0.0763382903952343 988 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_902 1120-0002 2.07 µM -1.43118059869456 0.0879944766007237 no 3058 0.07618923122383 952 3280475
SGTC_3315 9136395 68.55 µM -1.43147644555375 0.0879498087035941 no 3059 0.0761468564700855 1020 16876844
SGTC_3271 9137798 49.47 µM -1.43196750505251 0.0878757043120206 no 3060 0.0760765606127118 961 6498326
SGTC_2751 anetholtrithion 17.25 µM -1.43285260035083 0.0877422547259541 no 3061 0.0759499827616216 1019 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3149 9097855 49.47 µM -1.43520327612042 0.087388567347554 no 3062 0.0756145901657814 1004 25236625 YMR079W SEC14
SGTC_873 0591-4978 488 µM -1.44013958436764 0.0866493062335279 no 3063 0.0749139559189134 1022 3305145
SGTC_1055 3448-0672 86 µM -1.44081584730929 0.0865483942741795 no 3064 0.0748183575814158 1010 748378
SGTC_732 3970-1727 52.7 µM -1.44742967722184 0.0855661055042018 no 3065 0.0738883094435934 1019 1275699
SGTC_2518 prenyletin 46.28 µM -1.44753209633295 0.0855509600891157 no 3066 0.0738739768769491 1002 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2065 5221596 34.26 µM -1.44847851439555 0.0854111017428019 no 3067 0.0737416353080452 1000 788581
SGTC_2103 5378138 10 µM -1.44925925646074 0.0852958553831273 no 3068 0.0736325973779538 1005 244142
SGTC_1988 st071872 53.4 µM -1.45417121326052 0.0845734657425379 no 3069 0.0729494219378265 1020 16414116
SGTC_3334 9142812 21.919 µM -1.45838756542036 0.0839570456889409 no 3070 0.0723668730653491 1006 45283678
SGTC_38 0929-0051 58.268 µM -1.46282684362425 0.0833116868793179 no 3071 0.0717573829263145 1010 1379719
SGTC_57 miconazole 162.5 nM -1.46286085791626 0.0833067564985125 no 3072 0.0717527281856846 990 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2766 oltipraz 83.91 µM -1.464875296404 0.0830151541080717 no 3073 0.0714774719153664 947 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2616 abietic acid 100 µM -1.46508824691381 0.0829843731330596 no 3074 0.0714484214220813 1023 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2346 9031566 143.75 µM -1.4659992226043 0.0828527928746738 no 3075 0.071324249322934 1015 4771086
SGTC_1079 idarubicin 2.36 µM -1.46812495308159 0.0825463654324343 no 3076 0.0710351423190441 1008 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1022 4477-0945 21.3 µM -1.47130018848168 0.0820902401481245 no 3077 0.0706049761885313 1008 4648966
SGTC_383 2324-0395 7.37 µM -1.47364122342062 0.0817551663695255 no 3078 0.0702891079576382 941 3146421
SGTC_1506 4226-2149 212 µM -1.47748955338028 0.0812065943928243 no 3079 0.0697722282663416 1016 991114
SGTC_1686 st019653 115.5 µM -1.47889819119775 0.0810064916615081 no 3080 0.0695837634323815 1038 97252
SGTC_1948 st076329 66.6 µM -1.47998560690118 0.0808522745471261 no 3081 0.0694385439013034 1021 24208413
SGTC_3327 9140648 26.9345 µM -1.48016692932471 0.0808265810070016 no 3082 0.0694143518195168 1008 8029710
SGTC_575 k072-0246 11.9 µM -1.48561664360129 0.0800572258287839 no 3083 0.0686902750766002 1029 6796779
SGTC_1503 4585-0012 61.3 µM -1.4864608138709 0.0799385482462343 no 3084 0.0685786372247728 1025 2922052
SGTC_604 1000-0114 314 µM -1.49075507023853 0.079336899505865 no 3085 0.0680129058974174 1040 1572745
SGTC_435 c-PAF 6.7 µM -1.49231833940306 0.0791187300811279 no 3086 0.0678078556114678 1002 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2863 9028737 58.44 µM -1.49295295509529 0.0790302930488263 no 3087 0.0677247509739927 1021 6460917
SGTC_1403 3909-7815 62.9 µM -1.49338679818815 0.0789698778331372 no 3088 0.0676679833440591 1008 6615483
SGTC_2192 5915882 198.485 µM -1.49467960668722 0.0787900540470668 no 3089 0.0674990395281325 1022 2876149
SGTC_2308 7584454 197.62 µM -1.49715195692468 0.0784470256241893 no 3090 0.0671768615051193 1008 893577
SGTC_2439 5492030 7.2 µM -1.50192566799173 0.0777878982377689 no 3091 0.0665581533953479 992 5722370
SGTC_2647 atorvastatin 60.16 µM -1.50232739653122 0.077732622136828 no 3092 0.0665062883013412 1005 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1456 k015-0012 13 µM -1.50303172812792 0.0776357811413456 no 3093 0.0664154312122446 1020 2989616
SGTC_1946 st076057 65.1 µM -1.51299947894982 0.0762750834162829 no 3094 0.0651398956043345 1032 953009
SGTC_2555 cholic acid 100 µM -1.51681283106553 0.0757593495214374 no 3095 0.064656973278876 1019 6708657 Influences liver metabolism.
SGTC_4 0960-0234 25.671 µM -1.52602989667811 0.0745237671526863 no 3096 0.0635012095518413 1009 6821112
SGTC_1176 0848-0131 83.3 µM -1.53030279257886 0.073956214191266 no 3097 0.0629708986894494 1025 6769040
SGTC_3136 9095672 49.47 µM -1.53850445102416 0.0728760799264149 no 3098 0.0619626605322347 1005 17217380
SGTC_1618 st003135 44.5 µM -1.53896413740372 0.072815899889858 no 3099 0.0619065258222148 1044 1270615
SGTC_1487 3970-0795 2.82 µM -1.54019255727115 0.0726552674768497 no 3100 0.0617567117853064 1009 3765103
SGTC_2820 7989630 71.43 µM -1.54291512211638 0.0723002229066473 no 3101 0.0614256856124441 1007 2984098
SGTC_19 0279-0214 38.434 µM -1.54385150167741 0.0721784191630935 no 3102 0.0613121556938917 1037 3566274 YBR002C RER2
SGTC_1936 st074407 74.3 µM -1.54439562245426 0.072107712515467 no 3103 0.0612462599447411 1028 809813
SGTC_1305 1181-0477 144 µM -1.54473363865886 0.0720638152018545 no 3104 0.0612053523653385 1048 6252086
SGTC_2237 6667747 47.222 µM -1.54739725052015 0.0717186151297741 no 3105 0.0608837419182032 1046 729940 YDL015C TSC13
SGTC_492 tmb-8 126 µM -1.55001729597625 0.0713803000798315 no 3106 0.0605686823570567 1024 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1691 st019933 84.6 µM -1.55319265888912 0.0709719227655407 no 3107 0.0601885573125157 1044 6176082
SGTC_3084 9116877 49.47 µM -1.55948737009993 0.0701676797967612 no 3108 0.0594405357803338 1023 27241325
SGTC_1616 st002734 56.1 µM -1.56229339034292 0.069811435794151 no 3109 0.059109444197199 1035 4026101
SGTC_72 0744-0168 198.391 µM -1.56315823723661 0.0697019185048005 no 3110 0.0590076902092718 1039 677577
SGTC_645 0845-0943 5.41 µM -1.56359300549499 0.0696469129106131 no 3111 0.0589565892657529 1025 1885106
SGTC_2644 guaiazulene 100 µM -1.56536943263811 0.0694225117776587 no 3112 0.0587481557089847 1011 3515 A coloring agent.
SGTC_1807 st050092 58.9 µM -1.56749778630833 0.0691543884515432 no 3113 0.0584991916238137 1037 5008496
SGTC_297 0986-0032 24 µM -1.57083211935333 0.0687359447625978 no 3114 0.0581108246228134 1020 2847425
SGTC_1215 3852-0577 11.2 µM -1.57534229189343 0.0681730484699564 no 3115 0.0575887284931529 1018 2884876
SGTC_2976 9009005 19.48 µM -1.58222454331232 0.0673209684809579 no 3116 0.0567991596793862 1015 2993148
SGTC_230 MPP+ 141.667 µM -1.58498081301186 0.0669820372072802 no 3117 0.0564853468544219 1036 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_813 k007-0158 173 µM -1.58502165338733 0.0669770251147459 no 3118 0.0564807073006155 1033 6523916
SGTC_410 α-linolenic acid 100 µM -1.58844986627833 0.0665573345589795 no 3119 0.0560923245183233 1037 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3226 9131256 49.47 µM -1.58915386834843 0.0664714013126873 no 3120 0.0560128292813075 1012 17178073
SGTC_1158 4092-0494 91.8 µM -1.59089684163673 0.0662590167647122 no 3121 0.055816396741057 1040 1148199
SGTC_3168 9103419 49.47 µM -1.59626241029921 0.0656085105621176 no 3122 0.0552151093876924 1043 16649256
SGTC_1346 1488-2224 62.4 µM -1.59753817768328 0.0654545712443135 no 3123 0.055072897310635 1018 3722427
SGTC_196 k015-0023 18.111 µM -1.5987217033145 0.0653120128134457 no 3124 0.0549412264945917 1021 5211998
SGTC_109 0132-0036 33.701 µM -1.5994118237931 0.0652289974304552 no 3125 0.0548645633997954 980 67274 A color developer.
SGTC_2052 5265182 7.135 µM -1.5998658936043 0.0651744215220859 no 3126 0.0548141684888616 1028 1239884
SGTC_194 1486-1323 56.904 µM -1.604515820756 0.0646175712667453 no 3127 0.0543002000095522 1037 5178754
SGTC_1418 3966-3099 2.4 µM -1.60564685900206 0.0644826845644213 no 3128 0.0541757617371831 1023 740335
SGTC_3086 9117350 49.47 µM -1.60772606201267 0.0642352913166599 no 3129 0.0539475940128016 1013 2679265
SGTC_1445 4239-0156 97.7 µM -1.60838378478243 0.0641571861850935 no 3130 0.053875575392776 1053 4008346
SGTC_2899 9053889 58.44 µM -1.60862042364701 0.0641291031866923 no 3131 0.0538496827941192 1024 6470052
SGTC_598 3937-0236 20.2 µM -1.61232829113544 0.0636903207576092 no 3132 0.0534452600443536 1038 1379313
SGTC_33 0986-0033 35.816 µM -1.61267110070407 0.0636498715288505 no 3133 0.0534079911540153 1004 2848082
SGTC_1230 0170-0365 3.77 µM -1.61629646767265 0.063223325001902 no 3134 0.0530151150926002 989 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_727 3032-0951 202 µM -1.61763245894186 0.0630666999011674 no 3135 0.0528709147835396 1045 3652836
SGTC_198 3454-2873 16.191 µM -1.62402851970673 0.062321040052205 no 3136 0.0521848609651796 1027 710957
SGTC_1492 4158-0558 28.5 µM -1.632109956649 0.0613887501260947 no 3137 0.0513281623252415 1008 3967268
SGTC_2050 5263056 171 µM -1.63519756295019 0.0610354479051628 no 3138 0.0510038194425523 1036 763468 YGL055W OLE1
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.63764648569566 0.0607563594947208 no 3139 0.0507477299723641 1048 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1086 cerivastatin 2.18 µM -1.64487808250106 0.0599380424407605 no 3140 0.0499974778119612 1019 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2914 7968218 45.32 µM -1.64777308871852 0.0596128774047688 no 3141 0.0496996216670301 1017 2977111
SGTC_3176 9106582 49.47 µM -1.64955899820127 0.0594129757844891 no 3142 0.0495165834600624 1042 17018027
SGTC_1216 1165-0504 9.65 µM -1.64975664418927 0.0593908850756444 no 3143 0.0494963597941768 1047 6304004
SGTC_784 4579-0127 173 µM -1.65048612549168 0.0593094073644374 no 3144 0.0494217743813494 1041 1948547
SGTC_2076 5212012 200 µM -1.66542557308476 0.0576599834041916 no 3145 0.047913940455957 1036 604802
SGTC_891 0929-0073 133 µM -1.66926546209002 0.0572419133644765 no 3146 0.0475323908911431 1054 5603632
SGTC_153 4077-0274 519.67 µM -1.67425181254003 0.0567025862620441 no 3147 0.0470405602637992 1031 3121976
SGTC_3160 9100216 49.47 µM -1.67634687427611 0.0564771806386795 no 3148 0.0468351342061468 1041 17191039
SGTC_1714 st033236 13.627 µM -1.67721295145379 0.056384206793467 no 3149 0.0467504236596646 1026 2916566
SGTC_2262 9014885 67.46 µM -1.67868939124795 0.0562259883693819 no 3150 0.0466062972889304 1060 6457424
SGTC_1008 4106-0037 6 µM -1.68068678702043 0.0560125005365746 no 3151 0.046411884198285 1031 2905394
SGTC_1322 1348-1070 12 µM -1.68160643035762 0.055914421409753 no 3152 0.0463225914311823 1042 6758089
SGTC_992 3909-8734 162 µM -1.68820502353277 0.0552146555634698 no 3153 0.0456859396201489 1056 4288319
SGTC_2176 5809774 33.9695 µM -1.69058263480735 0.0549642172134873 no 3154 0.0454582717755097 1008 2870539
SGTC_1779 st039427 55 µM -1.69066881983724 0.0549551560658307 no 3155 0.045450036306726 1043 1124498
SGTC_2619 obliquin 87.91 µM -1.69106632744024 0.0549133789911513 no 3156 0.0454120677271588 1024 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2123 5259487 200 µM -1.69134393800896 0.0548842176889945 no 3157 0.0453855664381947 1044 2173474
SGTC_81 0411-0046 9.971 µM -1.69648753738848 0.0543461249634514 no 3158 0.0448967941825837 1028 12925265
SGTC_2794 7785382 27.27 µM -1.70139498683567 0.0538366356381575 no 3159 0.0444344210189118 1019 2205081
SGTC_2879 9041815 71.43 µM -1.70252894231259 0.0537194484862129 no 3160 0.0443281288592916 1054 4942971
SGTC_1705 st027868 56.3335 µM -1.70390394336844 0.0535776219074512 no 3161 0.0441995170973637 1025 292948
SGTC_1201 1889-3372 45.9 µM -1.70925380099414 0.053028623129093 no 3162 0.0437019734672638 1027 5392199
SGTC_2384 9036245 200 µM -1.71199337293554 0.05274922232714 no 3163 0.0434489448731797 1018 6462766
SGTC_21 0849-0113 22.993 µM -1.71568672352098 0.0523743986833135 no 3164 0.0431096980090346 1052 1560156
SGTC_1343 1487-0095 224 µM -1.71988174771647 0.0519512304997284 no 3165 0.0427269694771871 1039 4560101 YGL055W OLE1
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.72060808244455 0.0518782390009011 no 3166 0.0426609829100909 1030 3256 An antibiotic and ribosome inhibitor.
SGTC_2252 omeprazole 400 µM -1.72138732980957 0.0518000207994469 no 3167 0.042590280935519 1058 4594 A proton pump inhibitor.
SGTC_2866 9034245 58.44 µM -1.72919316527323 0.0510216596481179 no 3168 0.0418872645952136 1042 6462273
SGTC_1809 st050081 57.6 µM -1.72930336333031 0.0510107382253722 no 3169 0.0418774075056033 1045 5036894
SGTC_3139 9095020 49.47 µM -1.73905829152759 0.0500513046246615 no 3170 0.0410122550443311 1030 25236292
SGTC_2221 6807166 181.081 µM -1.74556438090401 0.0494194440719201 no 3171 0.0404433380717097 1052 674925
SGTC_2298 7976326 193.81 µM -1.74926941669637 0.0490624726986455 no 3172 0.0401222299383509 1064 2235818
SGTC_1644 st010134 20.9 µM -1.74990294936899 0.0490016400550114 no 3173 0.0400675308431303 1054 3818134
SGTC_884 0851-0618 334 µM -1.75064563370029 0.0489304032662896 no 3174 0.0400034847798051 1040 9642473
SGTC_399 oxolinic acid 75 µM -1.75664971428843 0.0483575379314504 no 3175 0.0394887668112617 1046 4628 A DNA gyrase inhibitor.
SGTC_739 1486-1183 203 µM -1.77100301916653 0.0470097824708416 no 3176 0.0382800998311928 1050 4346692
SGTC_1315 1237-0019 3.69 µM -1.77190511001621 0.0469260936061883 no 3177 0.0382051550176643 1033 825140
SGTC_56 0957-0365 83.25 µM -1.77346352136166 0.0467817980520303 no 3178 0.038075965680907 1047 6752360
SGTC_968 1309-0633 340 µM -1.77427672776783 0.046706643547079 no 3179 0.0380086940325065 1043 3761976
SGTC_1739 st037196 92.5 µM -1.77441167273509 0.046694181646262 no 3180 0.0379975402370087 1037 612214
SGTC_3215 9129942 49.47 µM -1.77479700058561 0.0466586120655311 no 3181 0.0379657058920876 1054 17682944
SGTC_3096 9117468 49.47 µM -1.77838603419089 0.0463283520131318 no 3182 0.0376702374108175 1042 41316311
SGTC_164 4100-3994 89.624 µM -1.78743388100889 0.0455041020461223 no 3183 0.0369336948458914 1060 4615967
SGTC_2667 digitoxin 100 µM -1.78963716705636 0.0453051807742605 no 3184 0.0367561297224803 1039 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1832 st054113 55 µM -1.79014678509194 0.0452592702216373 no 3185 0.0367151586469483 1045 1251267
SGTC_1882 5615643 20 µM -1.79311133929844 0.0449929406443874 no 3186 0.0364775614295847 1023 2253075
SGTC_3297 9117502 71.43 µM -1.79462544172263 0.0448574042011844 no 3187 0.0363566984068891 1045 7453720
SGTC_2 0422-0095 29 µM -1.79600363327119 0.0447343199223984 no 3188 0.0362469695983159 1030 6790840
SGTC_1679 SEC14.276 6.7 µM -1.79768094589195 0.044584888655652 no 3189 0.0361137913049171 1028 1005053 YMR079W SEC14
SGTC_115 0527-0192 112.043 µM -1.79809989565327 0.0445476273763741 no 3190 0.0360805893913469 1057 4233931
SGTC_423 5-fluorouracil 457 µM -1.80474172041125 0.0439602498584344 no 3191 0.0355575539917975 1025 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1096 rimcazole 32.2 µM -1.8096150946972 0.0435332527891342 no 3192 0.0351777487276087 1048 18528119 A dopamine reuptake inhibitor.
SGTC_1271 0832-2808 169 µM -1.81399764687621 0.0431521254607332 no 3193 0.0348390440216587 1055 3663794
SGTC_2941 9056145 11.23 µM -1.81733793036981 0.0428634523375952 no 3194 0.0345826927302571 1039 2119517
SGTC_249 wiskostatin 11.211 µM -1.81770789582431 0.0428315755046723 no 3195 0.0345543951486564 1036 2775510 A n-wasp and actin depolymerizer.
SGTC_780 0109-0199 192 µM -1.82660358644465 0.0420708602094335 no 3196 0.0338796968789105 1042 610414
SGTC_2402 5553605 200 µM -1.83291280650195 0.0415379841858315 no 3197 0.0334077694714189 1058 6758546
SGTC_287 k060-0039 29.6 µM -1.83532871336317 0.0413353904272491 no 3198 0.0332284995576622 1064 5861974
SGTC_2788 5282734 71.43 µM -1.8409850368719 0.0408641928060377 no 3199 0.0328118757425686 1045 743706
SGTC_2584 androsterone 48.74 µM -1.84110320060803 0.040854395888875 no 3200 0.0328032183723932 1004 2754130 A steroid.
SGTC_408 cantharidin 100 µM -1.84321069907626 0.0406799837172598 no 3201 0.0326491266910165 1051 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2876 9059903 25.97 µM -1.8520733192134 0.0399531343282948 no 3202 0.032007647595983 1056 6916095
SGTC_61 0978-8327 98.565 µM -1.85313801285915 0.0398665302834926 no 3203 0.0319312898038169 1037 6150059 YHR072W ERG7
SGTC_2861 9024595 19.48 µM -1.85427557571457 0.0397741676081766 no 3204 0.0318498722771324 1059 16482810
SGTC_2670 beta-carotene 100 µM -1.85600779846644 0.0396338566528815 no 3205 0.0317262232503811 1044 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_763 3453-1109 128 µM -1.86103393382667 0.0392290141006673 no 3206 0.0313696923922336 1061 1560353
SGTC_938 3126-1755 342 µM -1.86298169792087 0.0390730342059417 no 3207 0.0312324206228594 1049 1777771
SGTC_1012 4112-3522 18 µM -1.86316184643035 0.0390586331854751 no 3208 0.0312197495100667 1056 3112398
SGTC_1010 4112-3296 15.2 µM -1.87193046517083 0.0383628797753847 no 3209 0.030608112069632 1039 704384
SGTC_2430 5571206 200 µM -1.875230109559 0.0381036971846506 no 3210 0.0303805367999342 1051 1731771
SGTC_1620 st003704 16.5 µM -1.87702118490671 0.0379636097817089 no 3211 0.0302575951867795 1057 2834414
SGTC_1377 2944-0135 198 µM -1.88658784480303 0.0372224617068862 no 3212 0.0296078914648634 1038 1894137
SGTC_80 0159-0065 512.242 µM -1.89148511332039 0.0368476603429667 no 3213 0.0292798081755203 1056 1548079
SGTC_2595 hexamethylquercetagetin 100 µM -1.89175663166252 0.0368269709178895 no 3214 0.0292617070085865 1054 386331
SGTC_2669 eugenol 100 µM -1.89201632456021 0.0368071914684451 no 3215 0.0292444028990079 1056 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_844 0330-0132 15.3 µM -1.89496893368944 0.0365829169776536 no 3216 0.0290482587689066 1060 2828079
SGTC_1048 3161-0300 24.5 µM -1.90067844612458 0.0361524047419016 no 3217 0.028672071703979 1050 2165101
SGTC_2497 7-hydroxyflavone 100 µM -1.90873264348332 0.0355521592962106 no 3218 0.0281482949198291 1051 5281894
SGTC_2965 9082772 38.63 µM -1.91152311959181 0.0353461122298412 no 3219 0.0279686943061699 914 16459634
SGTC_3157 9099274 49.47 µM -1.91674038239511 0.0349635003057466 no 3220 0.0276354611265054 1043 17217662
SGTC_2212 7123476 200 µM -1.9168270253675 0.0349571750876728 no 3221 0.0276299551865943 1067 1085715
SGTC_1186 1319-0216 26 µM -1.91783159382711 0.0348839068822043 no 3222 0.0275661841526744 1058 4565136
SGTC_716 1683-5115 658 µM -1.92288197246045 0.0345174651443849 no 3223 0.0272474371374814 1054 723597
SGTC_1140 3229-1848 2.98 µM -1.92344849968675 0.0344765574564321 no 3224 0.0272118741869644 1053 2849525
SGTC_2493 resveratrol 26.09 µM -1.92437401371881 0.0344098138121586 no 3225 0.0271538596512524 1055 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2201 6605497 169.863 µM -1.92639963922861 0.0342641058330925 no 3226 0.0270272462271808 1069 670741
SGTC_967 1306-0166 352 µM -1.92697358439194 0.0342229129427859 no 3227 0.0269914610160397 1065 4437607
SGTC_1341 1486-1360 280 µM -1.92961351608811 0.0340339650760104 no 3228 0.0268273714240389 1069 3976547
SGTC_609 0986-0026 86.3 µM -1.93242842261637 0.0338334396176866 no 3229 0.0266533243660548 1045 2848610
SGTC_1793 st048256 72.231 µM -1.94263953831682 0.0331141725435083 no 3230 0.0260298630941254 1043 672022
SGTC_1926 methyl fluorone black 53.6 µM -1.94314644099796 0.033078797266989 no 3231 0.0259992335834117 1009 72721 Reacts with homocysteine.
SGTC_3105 9121040 49.47 µM -1.94862174716609 0.0326986723795938 no 3232 0.0256703065418944 1042 41448907
SGTC_2685 mycophenolic acid 18.85 µM -1.94915245960313 0.0326620197597071 no 3233 0.025638610197562 1051 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2946 9065502 71.43 µM -1.95659498466903 0.0321515759200627 no 3234 0.0251975525732672 1024 16489101
SGTC_959 1222-0044 107 µM -1.96411005368111 0.0316428567034199 no 3235 0.0247586652810896 1058 6083612
SGTC_1138 3761-0006 1.03 µM -1.96572421980848 0.0315344609413032 no 3236 0.0246652377681669 1068 12061087
SGTC_2891 9063876 19.48 µM -1.97314627545158 0.0310399921578368 no 3237 0.0242394496635616 1066 6472478
SGTC_3183 9108214 49.47 µM -1.97424352281971 0.0309674390942693 no 3238 0.0241770296618313 1078 4974831
SGTC_370 0180-0345 38.7 µM -1.99223534476801 0.0297976533476367 no 3239 0.0231726209508827 1032 3989527
SGTC_217 ketoconazole 989 nM -1.99491039127901 0.0296268995139647 no 3240 0.0230263269926546 1046 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2583 asiatic acid 100 µM -1.99583776302976 0.0295678933143966 no 3241 0.0229757924441816 1064 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_863 0466-0191 129 µM -1.99722914159157 0.0294795465801643 no 3242 0.0229001483703652 1073 765160 YPR165W RHO1
SGTC_1927 st060202 13.8 µM -1.99972229158875 0.0293217901182411 no 3243 0.0227651298581788 1049 688887
SGTC_2230 bromochlorosalicylanilide 954.5 nM -2.00338509794522 0.0290912946394454 no 3244 0.0225679848682704 1052 77254
SGTC_1938 st074717 56.4 µM -2.01475359665657 0.0283854587168345 no 3245 0.0219652366655843 1039 17250979
SGTC_1805 st050013 60.3 µM -2.01483876100649 0.0283802253809991 no 3246 0.0219607731238366 1064 4037144
SGTC_2764 methyldopa 94.69 µM -2.01601198767657 0.0283082124672905 no 3247 0.0218993611400218 1065 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2107 5363541 170.161 µM -2.02711236809681 0.0276343656437567 no 3248 0.0213254611467391 1061 244052
SGTC_2711 st079103 59.1 µM -2.04052358527391 0.0268381264842971 no 3249 0.0206491021950444 1070 54693780
SGTC_135 0933-0004 26.348 µM -2.04521604375465 0.0265640929072201 no 3250 0.0204167817240264 1044 21230617 YGL099W LSG1
SGTC_199 4063-0024 41.6 µM -2.04854708421983 0.0263709863447389 no 3251 0.0202532117525042 1080 306215
SGTC_2576 guaiol 23.12 µM -2.05047498689698 0.026259759288044 no 3252 0.0201590511167055 1056 227829
SGTC_27 0485-0001 32.618 µM -2.05806601894634 0.0258256129760252 no 3253 0.0197918982160049 1058 2054479
SGTC_1220 1838-0075 193 µM -2.05851681449972 0.0258000211359468 no 3254 0.019770274436019 1050 5529645
SGTC_576 1073-0113 22.7 µM -2.06724703025096 0.0253085738076241 no 3255 0.0193554413426774 1062 5439563
SGTC_602 3130-1533 38.1 µM -2.06843057023726 0.0252425567990173 no 3256 0.0192997765298347 1072 720941
SGTC_1183 1254-0324 198 µM -2.06958980120304 0.0251780356689966 no 3257 0.0192453869722159 1061 5799357
SGTC_102 gallobenzophenone 83.616 µM -2.08330907027237 0.024424881989564 no 3258 0.0186115302535205 1043 70837
SGTC_1339 1486-1321 22.7 µM -2.08627509120476 0.0242645656344727 no 3259 0.018476855819826 1069 3469382
SGTC_564 3555-0129 330 µM -2.1031125844448 0.0233711397954358 no 3260 0.0177279645799829 1058 563260
SGTC_2421 5690543 90.72 µM -2.10388470986163 0.0233308422849647 no 3261 0.0176942525324698 1059 3397993
SGTC_2898 9056270 58.44 µM -2.10652767177689 0.0231933475168121 no 3262 0.0175792710127272 1052 19154699
SGTC_452 diindolylmethane 8 µM -2.1070227191261 0.0231676696764942 no 3263 0.0175578051465731 1073 3071 Inhibits expression of several cancer promoting factors.
SGTC_2843 9000894 45.46 µM -2.10795691391712 0.023119278691153 no 3264 0.0175173582506986 1065 2242070
SGTC_2886 9058944 51.95 µM -2.11657922216573 0.0226766504955896 no 3265 0.0171477875364404 1079 4949929
SGTC_2143 5623677 140.463 µM -2.12518451876914 0.0222420389074586 no 3266 0.0167856096527102 1055 5375313
SGTC_635 k038-0028 24.7 µM -2.13776278676671 0.0216194302948997 no 3267 0.0162680003585241 1081 4035102
SGTC_2311 7694451 200 µM -2.14030354122195 0.0214954704295952 no 3268 0.0161651219968531 1075 2163142
SGTC_862 0452-0056 10.2 µM -2.14515893868726 0.0212602529936362 no 3269 0.0159700706861581 1081 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3018 9082602 49.47 µM -2.14762967736218 0.0211413972994588 no 3270 0.0158715929429777 1040 17332089
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.15118200493746 0.0209714968389424 no 3271 0.0157309184082651 1067 17037758
SGTC_291 SEC14.278 35.5 µM -2.155727680467 0.0207557733110236 no 3272 0.015552467713085 1074 1068044
SGTC_234 nsc-17383 10.7 µM -2.15924222891432 0.0205902745393048 no 3273 0.0154156897348495 1063 408974
SGTC_1913 st060213 96.1 µM -2.16582776884555 0.0202831728785908 no 3274 0.0151621752642199 1071 688959
SGTC_2847 9005661 71.43 µM -2.18430522895142 0.019442176276379 no 3275 0.0144699134015459 1076 2991449
SGTC_2175 5807670 165.306 µM -2.20985523193806 0.0183282106808982 no 3276 0.0135576055377847 1067 241186
SGTC_2284 7945075 39.21 µM -2.21080465428087 0.0182878864256513 no 3277 0.0135246837025205 1066 1245402
SGTC_2808 7946468 45.46 µM -2.21184334992029 0.0182438571264715 no 3278 0.0134887453251286 1065 2970879
SGTC_2839 9003951 25.97 µM -2.21769618054475 0.0179974462370685 no 3279 0.013287777428933 1060 2990634
SGTC_2707 st078556 66.6 µM -2.21942312411381 0.0179252843368345 no 3280 0.013228975956816 1063 17250899
SGTC_1521 st012942 49.4 µM -2.22183918499534 0.0178247412310485 no 3281 0.0131470877636639 1078 24207259
SGTC_790 1575-0012 79.1 µM -2.23014624459004 0.0174827097551791 no 3282 0.0128688677987948 1052 378741 YLR208W SEC13
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.2509193595182 0.0166518441831947 no 3283 0.0121953226677611 1067 756377
SGTC_1540 guanosine 70.6 µM -2.27715722591148 0.0156508904161667 no 3284 0.0113884192015151 1080 6802 Guanosine is a purine nucleoside
SGTC_1698 5-fluorocytosine 1.055 µM -2.28869746291496 0.015227255941015 no 3285 0.0110484682709865 1072 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1435 4092-0789 56.7 µM -2.29129434116205 0.0151332956615806 no 3286 0.0109731978402114 1080 2248285
SGTC_2215 7188065 200 µM -2.29796000494842 0.0148943959526716 no 3287 0.0107820327785619 1079 940217
SGTC_608 k048-0125 159 µM -2.30558203775946 0.0146252002715939 no 3288 0.0105669989538809 1080 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2010 4012422 159 µM -2.31369088864277 0.0143434175508617 no 3289 0.0103423420219724 1072 952393
SGTC_1434 4073-0095 163 µM -2.34016537685124 0.0134557410696632 no 3290 0.00963760130741237 1080 24133745
SGTC_801 0866-0028 10.1 µM -2.35111547341406 0.0131026945994851 no 3291 0.00935861212439678 1081 6849771
SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.36475865446387 0.0126740440289335 no 3292 0.00902091198123681 1076 6708630 An antioxidant.
SGTC_2840 9008771 71.43 µM -2.3713827283098 0.012470337645253 no 3293 0.00886083475936476 1078 2992978
SGTC_798 1287-0182 476 µM -2.37662369049581 0.0123111802112317 no 3294 0.00873595123009292 1089 1649755
SGTC_2204 7233102 200 µM -2.38099588341941 0.0121797549411791 no 3295 0.00863295244925568 1082 2172480
SGTC_3314 9135860 59.4275 µM -2.40393622698076 0.011509929723795 no 3296 0.00810980126206325 1071 25252478
SGTC_2551 apiole 73.87 µM -2.41142010334913 0.0112984452794987 no 3297 0.00794526651841257 1085 10659 A possible DNA adduct former.
SGTC_2435 5706476 10.6 µM -2.41708746941831 0.0111405479279345 no 3298 0.00782262850853481 1081 5725375
SGTC_910 3454-3003 490 µM -2.42211548333619 0.0110020732824743 no 3299 0.00771522302199366 1079 820824
SGTC_2716 st080858 38.6235 µM -2.43725442285243 0.0105941402914846 no 3300 0.00739963132369814 1074 5296050
SGTC_1717 st033143 58.0435 µM -2.45983660819735 0.0100101381448514 no 3301 0.00695001408124843 1083 674616
SGTC_1088 bifonazole 369 nM -2.52403552693234 0.00850068724215214 no 3302 0.00580081016453763 1080 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_822 1487-0950 154 µM -2.53501203976145 0.00826365236815016 no 3303 0.00562217306802003 1074 1958375
SGTC_367 0335-0881 7.1 µM -2.53943667278554 0.00816975759619937 no 3304 0.00555155720507603 1078 23828853
SGTC_2693 st077581 40.7 µM -2.55212536048883 0.0079056708579725 no 3305 0.00535339936477237 1057 25238761
SGTC_2770 toltrazuril 17.5 µM -2.58415893264084 0.00727209324730396 no 3306 0.0048808399912074 1068 68591 Kills coccidiodes.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.58436014648129 0.00726825929908338 no 3307 0.00487799309025414 1079 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2263 7948595 193.29 µM -2.59379418937375 0.00709049112345592 no 3308 0.00474616452421409 1086 2971371
SGTC_803 4488-1585 147 µM -2.59967012218317 0.00698171828418951 no 3309 0.00466567066594102 1078 747204
SGTC_1654 st012436 41.8 µM -2.61142475206786 0.00676853338331283 no 3310 0.00450829140850041 1090 4323132
SGTC_1508 1080-0625 72.9 µM -2.65946355165873 0.00595589347306117 no 3311 0.00391325988977936 1064 767111
SGTC_807 1315-0151 48 µM -2.66656405640979 0.0058434223930487 no 3312 0.00383155007263797 1090 4011080
SGTC_2692 st077426 47.7 µM -2.67194414525608 0.00575946128865255 no 3313 0.00377065999129233 1087 25238571
SGTC_565 1418-0001 44.5 µM -2.71899777185166 0.00506959265198618 no 3314 0.00327400245934362 1089 2862145
SGTC_1932 st074806 40.9 µM -2.72863035021766 0.00493779657657325 no 3315 0.00317989747853348 1078 17251235
SGTC_865 0488-0499 301 µM -2.73632674165746 0.00483469523741425 no 3316 0.00310646511354512 1082 9634651
SGTC_846 0335-0850 148 µM -2.75042011620311 0.00465086330271576 no 3317 0.00297594508823056 1088 6819598
SGTC_333 3486-0131 40.1 µM -2.75438393264567 0.00460029622991843 no 3318 0.00294013713922994 1089 6744690
SGTC_2220 6782180 200 µM -2.75481378085736 0.00459484218330218 no 3319 0.00293627745167065 1091 833803
SGTC_2935 9038016 29.96 µM -2.77837500780197 0.00430457761630679 no 3320 0.00273157636297086 1074 6463195
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.77959973546594 0.00428994781439112 no 3321 0.00272129687691471 1087 4000243
SGTC_2608 thymoquinone 42.66 µM -2.78400228742844 0.00423772418334405 no 3322 0.00268463277531315 1083 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2004 4023728 41.89 µM -2.78705340822065 0.00420186567755046 no 3323 0.00265948559770139 1082 360084 YDR527W RBA50
SGTC_1169 aniline yellow 25.8 µM -2.82874699481391 0.00373834115633209 no 3324 0.00233653129445664 1084 6051 A DNA damaging agent.
SGTC_2625 euphol 100 µM -2.85207035352725 0.00349954615776697 no 3325 0.00217177430515724 1086 6708538 A triterpene alcohol.
SGTC_797 k781-0471 270 µM -2.86720837620946 0.0033519797845846 no 3326 0.002070551278599 1088 23738129
SGTC_2491 paeonol 100 µM -2.88650971222445 0.00317195175969878 no 3327 0.0019477036218082 1089 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2763 lisinopril 49.32 µM -2.92869142575725 0.00280845672806255 no 3328 0.00170196080551582 1081 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2791 5663188 71.43 µM -2.92932945420126 0.00280325962615815 no 3329 0.0016984708346718 1086 54690634
SGTC_1333 1482-0047 286 µM -2.92950618685636 0.0028018215743447 no 3330 0.00169750527245516 1091 3811116
SGTC_2814 7977482 42.97 µM -2.9543155694282 0.0026064335624929 no 3331 0.00156681696551026 1088 6456762
SGTC_3313 9133968 57.047 µM -3.00852965418857 0.00222165363268362 no 3332 0.00131257590644599 1086 1494643
SGTC_1923 st058458 19.1 µM -3.02321672688249 0.00212667815698343 no 3333 0.0012505152862087 1089 3534982
SGTC_2199 6590217 200 µM -3.08133406195512 0.00178590498396296 no 3334 0.00103037651901188 1090 703109
SGTC_2288 7946289 167.31 µM -3.10767621156024 0.00164847172554188 no 3335 0.00094282267517611 1085 1246052
SGTC_84 0443-0269 128.823 µM -3.12823349583693 0.00154799013884047 no 3336 0.000879302065109016 1091 6150058
SGTC_2545 solidagenone 89.61 µM -3.15002187958633 0.00144761440551921 no 3337 0.000816291177717105 1094 6708572 An anti ulcer agent
SGTC_2708 st078559 56 µM -3.16889178100487 0.00136552335604387 no 3338 0.000765106797763596 1089 17250902
SGTC_85 0868-0259 160.055 µM -3.17603708847996 0.00133556519766821 no 3339 0.000746509308646237 1088 83173
SGTC_2550 chrysin dimethyl ether 71.87 µM -3.27067630797978 0.000991567691515664 yes 3340 0.000536453198151209 1093 88881 An O-methylated flavonoid and antioxidant.
SGTC_1324 1418-0026 34.4 µM -3.27089647023126 0.000990872319214994 yes 3341 0.000536035750251634 1090 1372513
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -3.29535221196311 0.000916358382471223 yes 3342 0.000491491961494031 1088 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2605 digitonin 300 nM -3.37464897487208 0.00070873667653697 yes 3343 0.000369549499660466 1092 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1270 0831-1170 17.3 µM -3.44277779134522 0.0005659726913434 yes 3344 0.000287886096257003 1091 6764716
SGTC_2602 kawain 100 µM -3.54700803344938 0.000398172213590869 yes 3345 0.000194816355038305 1088 5369129
SGTC_1332 1480-0653 17.5 µM -3.56192173384223 0.000378350719447714 yes 3346 0.000184075072091113 1094 5749438
SGTC_1372 2752-0194 270 µM -3.69166316269648 0.000240737086229014 yes 3347 0.000111396199817215 1093 823334
SGTC_1935 st074532 41.6 µM -3.74194142264135 0.000201277591565855 yes 3348 9.13020424629829e-05 1093 2829742
SGTC_610 4215-0184 155 µM -3.75339888411125 0.000193173972282633 yes 3349 8.72264607739066e-05 1091 5605015
SGTC_1338 1486-1223 76 µM -3.83970594501579 0.000141241939061671 yes 3350 6.15908806393434e-05 1094 3444526
SGTC_1340 1486-1359 257 µM -3.91508179394527 0.000106896436014148 yes 3351 4.51867825810497e-05 1093 4309068
SGTC_916 4466-0038 42 nM -4.07792044914289 5.75993150413049e-05 yes 3352 2.27201537827141e-05 1092 5722064 YGL116W CDC20
SGTC_1370 2001-0092 44.6 µM -4.19315250787199 3.66833166626444e-05 yes 3353 1.3755217861971e-05 1083 790957
SGTC_1924 st058459 75.1 µM -4.74785995046596 3.56684792615255e-06 yes 3354 1.02790152107869e-06 1094 688683
SGTC_1379 2144-0755 36.5 µM -5.48436919680967 1.07344484871591e-07 yes 3355 2.07473687387175e-08 1095 5392327