SGTCid condition conc unit TRP2|YER090W.score TRP2|YER090W.strain.pval TRP2|YER090W.strain.significant TRP2|YER090W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2758 dehydroepiandrosterone 69.35 µM 22.4232930711692 2.44983658998973e-25 yes 1 1.16636417820386e-111 4 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1455 4262-0120 131 µM 22.1016796509054 1.16016077265304e-24 yes 2 1.52263049877517e-108 1 1529587
SGTC_2254 7938975 95.19 µM 21.5744561143548 1.41475861465687e-23 yes 3 1.56064733872438e-103 3 2969277
SGTC_2093 5331342 194.4 µM 20.935023419808 2.71040870812976e-22 yes 4 1.28469376479252e-97 2 33839
SGTC_1617 st002906 78 µM 20.074878987567 1.25189849958112e-20 yes 5 6.11901566713353e-90 2 5150859
SGTC_2472 5377652 49.4 µM 20.0440624834642 1.43191942147084e-20 yes 6 1.13713009626938e-89 2 1610903
SGTC_2778 tioconazole 65.09 nM 19.5503784060511 1.19828846554441e-19 yes 7 2.04736254713361e-85 2 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1603 st002045 67.8 µM 18.8178224876574 2.5444573856633e-18 yes 8 2.69784548658134e-79 3 5887985
SGTC_1457 k015-0032 57.3 µM 18.5415727189376 7.81613214067842e-18 yes 9 4.76954493156877e-77 1 4302660
SGTC_2137 5261020 140 µM 18.3420857714409 1.73987213734818e-17 yes 10 1.90930524900251e-75 2 763655
SGTC_1572 epiandrosterone 68.9 µM 17.3908205995338 7.0238930302337e-16 yes 11 4.84189016418704e-68 1 441302 A steroid.
SGTC_2752 diclazuril 33.15 µM 16.6466876642713 1.10675439433608e-14 yes 12 1.59910520067253e-62 6 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1011 4112-3381 17.4 µM 16.2511176875517 4.56661518632977e-14 yes 13 1.09664547123719e-59 1 2877139
SGTC_1104 tacrolimus 29.8 µM 15.936152004467 1.37811884349021e-13 yes 14 1.7779332418135e-57 3 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2255 7941087 197.44 µM 15.8423698502429 1.90691920019796e-13 yes 15 7.93622009645959e-57 1 935561
SGTC_2725 haloperidol 53.21 µM 15.8238465317136 2.03279699434274e-13 yes 16 1.06534050884043e-56 3 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1999 st074831 12.5 µM 15.0329235656356 2.90877380944305e-12 yes 17 2.23420611997239e-51 3 17112523
SGTC_3018 9082602 49.47 µM 14.6142192525715 1.12705142825724e-11 yes 18 1.13976279707814e-48 4 17332089
SGTC_1041 0206-0046 107 µM 14.5441534435771 1.40860370565245e-11 yes 19 3.18064609177739e-48 1 50494
SGTC_2409 alverine citrate 63.97 µM 14.3927354638724 2.27260049556126e-11 yes 20 2.87384165660396e-47 3 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3308 9128332 17.569 µM 14.1109517634369 5.46321789789186e-11 yes 21 1.62579840633391e-45 13 17332805 YDL196W YDL196W
SGTC_1975 st070967 30.8 µM 14.0451876094662 6.68792515095198e-11 yes 22 4.12248760761241e-45 3 261391
SGTC_2296 7971656 126.45 µM 13.7143333575768 1.82449653920834e-10 yes 23 4.16643731200721e-43 2 666570
SGTC_2312 7706453 155.7 µM 13.713193360174 1.83074263654741e-10 yes 24 4.2324339530672e-43 2 976098
SGTC_2776 terbinafine 19.92 µM 13.6535203471649 2.18852894725665e-10 yes 25 9.61784256919552e-43 6 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2939 9044578 71.43 µM 13.6021427547872 2.55056331529147e-10 yes 26 1.94435550217338e-42 6 2653634
SGTC_2304 7443016 91.4 µM 13.4270232639576 4.27966272054765e-10 yes 27 2.09977919367828e-41 1 939854
SGTC_2090 5301565 104.445 µM 13.2379726653827 7.42813707516441e-10 yes 28 2.64795725555139e-40 3 2056344
SGTC_2461 5755302 26.15 µM 13.1985751998706 8.32469970774776e-10 yes 29 4.4705092993291e-40 1 2788904
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 13.1608675671192 9.28111603630848e-10 yes 30 7.36918736517135e-40 1 2333 A French combination drug.
SGTC_1883 5-benzylidenerhodanine 20 µM 13.1451300869557 9.71121796492326e-10 yes 31 9.07465661549775e-40 9 1273210
SGTC_2540 epiandrosterone 100 µM 13.0597801051928 1.24042771986217e-09 yes 32 2.79444927956575e-39 6 441302 A steroid.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 12.9250354061542 1.81977258449907e-09 yes 33 1.62573457662325e-38 3 1273210
SGTC_2163 5671233 125 µM 12.8868581018843 2.02708240886289e-09 yes 34 2.66871648132741e-38 1 701023
SGTC_2636 apigenin dimethyl ether 100 µM 12.5263882015696 5.52888202044947e-09 yes 35 2.67730869652432e-36 2 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_51 1013-0126 23.419 µM 12.5045404026156 5.87034269462744e-09 yes 36 3.5253209271924e-36 4 1627850
SGTC_2038 4100038 30.985 µM 12.4388915047147 7.02429452762806e-09 yes 37 8.03594105249012e-36 12 3596803
SGTC_2618 avocadyne 43.43 µM 12.3627811374007 8.63902350800414e-09 yes 38 2.07763747454451e-35 10 3015189
SGTC_1909 st060837 51.5 µM 12.3525205484386 8.88256269175135e-09 yes 39 2.36043981203587e-35 2 678937
SGTC_1952 st077036 64.1 µM 12.3140387521311 9.85674111542122e-09 yes 40 3.80583395688497e-35 2 2937007
SGTC_2777 climbazole 1.536 µM 12.1168816131225 1.671649632326e-08 yes 41 4.29841394475073e-34 2 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1019 4262-0212 3.4 µM 12.0625245182689 1.93092605902316e-08 yes 42 8.32983690888192e-34 4 4677213
SGTC_1699 st031318 29.054 µM 11.9828245595435 2.38281188398396e-08 yes 43 2.1858524818355e-33 1 5340658
SGTC_2488 5268135 45.7 µM 11.8401824041577 3.46000760751492e-08 yes 44 1.20963116267473e-32 7 1270356 YLR208W SEC13
SGTC_2468 5987765 72.9 µM 11.8027380279194 3.81319953462179e-08 yes 45 1.88907330992348e-32 1 26772094
SGTC_2642 cholecalciferol 100 µM 11.8007354279589 3.83304137288641e-08 yes 46 1.93457543218782e-32 3 9821465 A vitamin D precursor, similar to steriods.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 11.6956605135476 5.02678995552619e-08 yes 47 6.70697220268688e-32 1 688761
SGTC_2036 5160441 105 µM 11.6656059643425 5.42979339065644e-08 yes 48 9.55190297492668e-32 13 134534 YIL048W NEO1
SGTC_1797 st048695 56.8 µM 11.6093991885823 6.26898109395841e-08 yes 49 1.84600304125438e-31 14 592262 YIL048W NEO1
SGTC_1520 flindersine 88 µM 11.5771544636239 6.8056786350813e-08 yes 50 2.69012109782543e-31 1 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1636 st007707 68.9 µM 11.518613902908 7.89577324368745e-08 yes 51 5.31536607268747e-31 8 403051
SGTC_1717 st033143 58.0435 µM 11.4815523952862 8.67123709948054e-08 yes 52 8.1660721919164e-31 3 674616
SGTC_1881 5652484 16 µM 11.2213807694169 1.66016247570307e-07 yes 53 1.60115501778635e-29 9 2255129
SGTC_2299 7976368 114.88 µM 11.1514567831264 1.97197446006872e-07 yes 54 3.52217581435162e-29 1 2979718
SGTC_1114 scopoletin 1.73284 µM 11.0791580279265 2.35352814533926e-07 yes 55 7.91773358114308e-29 1 5280460 A coumarin with genotoxic properties.
SGTC_1697 st025554 27.742 µM 11.0687054417744 2.41426942474281e-07 yes 56 8.89763326571524e-29 4 1269519
SGTC_2232 chlorophetanol 41.5365 µM 10.9789873996825 3.00165060231065e-07 yes 57 2.41149764274719e-28 10 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1715 st032160 10.2275 µM 10.6561286841792 6.4803393331342e-07 yes 58 8.16261039069292e-27 4 5289825
SGTC_2301 7769476 200 µM 10.6553065126124 6.4928702438371e-07 yes 59 8.23506042860803e-27 4 977820
SGTC_926 2268-1401 59.4 µM 10.5871837276158 7.61618045566123e-07 yes 60 1.70859137614636e-26 5 2931578
SGTC_2733 amorolfine 100 µM 10.3339315599221 1.36662705889006e-06 yes 61 2.47448130095857e-25 3 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2203 7227154 166.4 µM 10.2678916435587 1.58818020677586e-06 yes 62 4.9165040727974e-25 2 896304
SGTC_1882 5615643 20 µM 10.1589766575288 2.03068540379574e-06 yes 63 1.51115968421269e-24 8 2253075
SGTC_1072 oxiconazole 14.9 nM 10.1427072595604 2.10617638516338e-06 yes 64 1.78532149928948e-24 6 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1159 4092-0538 61.2 µM 10.0710992226723 2.47160641205899e-06 yes 65 3.70723649641356e-24 2 717301
SGTC_2231 micatex 6.853 µM 9.89620717207892 3.6368203357862e-06 yes 66 2.16181117823228e-23 3 20737 An antifungal of unknown mechanism.
SGTC_50 0929-0078 56.389 µM 9.8877819921301 3.70452314414547e-06 yes 67 2.35166444055078e-23 7 1377751
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 9.8591548350916 3.94368387259501e-06 yes 68 3.12869329799579e-23 2 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2384 9036245 200 µM 9.7822406489359 4.66156205266473e-06 yes 69 6.71030039393661e-23 11 6462766
SGTC_2152 5568786 200 µM 9.7792296161241 4.69206282249747e-06 yes 70 6.9129437659371e-23 1 5399883
SGTC_2249 haloperidol 116.36 µM 9.67285623859208 5.90059518507194e-06 yes 71 1.96623330153682e-22 15 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2684 capsaicin 100 µM 9.65011090345844 6.19505057575911e-06 yes 72 2.45512986716203e-22 2 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2408 sulbentine 18.36 µM 9.59525632536283 6.96396114023328e-06 yes 73 4.18543863644915e-22 6 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2735 sertaconazole 140 nM 9.52560054489031 8.07205924815472e-06 yes 74 8.20451934332729e-22 3 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2148 5546263 113.568 µM 9.46036529533608 9.26068895684729e-06 yes 75 1.53434633071893e-21 1 792097
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 9.45699583157852 9.32640464143309e-06 yes 76 1.58458700168633e-21 2 688801
SGTC_1673 st016611 27.3 µM 9.34096140184587 1.18806650239533e-05 yes 77 4.77316507990643e-21 7 5226799
SGTC_1778 st046819 58.9 µM 9.26730268873941 1.38338117913322e-05 yes 78 9.54563203347451e-21 2 671715
SGTC_505 gw-5074 63.9 µM 9.24821443352671 1.43877014001956e-05 yes 79 1.14137009249787e-20 15 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1482 3346-2049 8.48 µM 9.23498945646968 1.4783748342298e-05 yes 80 1.29155726775135e-20 9 3826804
SGTC_2197 6588183 93.1375 µM 9.14719336046511 1.76877957505475e-05 yes 81 2.92159342696952e-20 4 884136
SGTC_860 0443-0016 25.1 µM 9.07970327976908 2.02802813560773e-05 yes 82 5.44356212406813e-20 3 5337942
SGTC_409 arachidonic acid 100 µM 9.04730528041932 2.16492160373966e-05 yes 83 7.32699486168903e-20 1 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1847 st056231 15 µM 8.99089853415919 2.42441167022678e-05 yes 84 1.22608678771918e-19 2 5393180
SGTC_1076 itraconazole 331 nM 8.85279654138376 3.18979443652256e-05 yes 85 4.2676587295407e-19 1 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1194 1488-0194 225 µM 8.80312813647989 3.51719344101546e-05 yes 86 6.6527249707572e-19 2 1391452
SGTC_180 1486-1293 102.781 µM 8.76692807677003 3.77557469817034e-05 yes 87 9.18034956746438e-19 13 4140536
SGTC_1720 st037298 9.481 µM 8.71998385761354 4.13743673529461e-05 yes 88 1.39120727661974e-18 3 597396
SGTC_1026 k007-1105 30.6 µM 8.71373595081239 4.18799899400019e-05 yes 89 1.47010388971915e-18 16 7066794
SGTC_820 1582-0060 59.9 µM 8.63725526699887 4.85618494826255e-05 yes 90 2.87898157433386e-18 1 3848840
SGTC_819 1013-0258 27.7 µM 8.61150295070319 5.10297759222008e-05 yes 91 3.60544417078619e-18 11 5753198
SGTC_410 α-linolenic acid 100 µM 8.57196659979239 5.50502187372883e-05 yes 92 5.08662990595968e-18 4 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_933 2914-0560 114 µM 8.54742795834901 5.76939067144014e-05 yes 93 6.29309013437782e-18 5 463887
SGTC_2094 5332512 191.667 µM 8.53714678866476 5.88367680992831e-05 yes 94 6.8788367780345e-18 3 755774
SGTC_1710 st031758 61.5 µM 8.52465001650537 6.02546659018944e-05 yes 95 7.66362723734833e-18 2 5394341
SGTC_1058 3448-5425 97.3 µM 8.51099466476624 6.18408264821759e-05 yes 96 8.62237863375989e-18 7 7279705
SGTC_129 0088-0017 176.636 µM 8.50890593578298 6.20868896367326e-05 yes 97 8.77911023652256e-18 15 182446
SGTC_2403 6032726 181.2 µM 8.49849116586307 6.33276387990978e-05 yes 98 9.60354323599121e-18 3 2881040
SGTC_1835 st008666 49.2 µM 8.4827104134828 6.52522735016312e-05 yes 99 1.10003873804597e-17 3 690455
SGTC_1101 ebselen 5.29 µM 8.44004099622456 7.07359847986343e-05 yes 100 1.58613190510983e-17 1 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2607 solasodine 47.35 µM 8.40221298240972 7.59577271504504e-05 yes 101 2.1907112456963e-17 16 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1600 coumarin 106 71.1 µM 8.38208997894974 7.88812723297536e-05 yes 102 2.5998030279339e-17 1 100336 A hepatotoxic, DNA x-linker.
SGTC_2162 5663267 200 µM 8.37780294796802 7.95176425992517e-05 yes 103 2.69624139355679e-17 1 6456493
SGTC_515 4092-1064 102 µM 8.34544272572068 8.44794401984282e-05 yes 104 3.5473798648206e-17 16 717353
SGTC_823 0417-1665 178 µM 8.23109732049421 0.000104444396311992 yes 105 9.27530878637361e-17 7 3429856
SGTC_2699 st077704 54.6 µM 8.1794660376201 0.000114842492052521 yes 106 1.42552206434633e-16 10 645852
SGTC_723 4182-0001 115 µM 8.16161137977501 0.000118658925812033 yes 107 1.6529217642633e-16 8 744821 YLR208W SEC13
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 8.16100030919262 0.000118791624745117 yes 108 1.66130659848973e-16 4 688788
SGTC_1030 k029-0042 36.7 µM 8.15981284882406 0.000119049889679913 yes 109 1.67772045559616e-16 3 6080581
SGTC_507 nimesulide 162 µM 8.00011309962445 0.000159009786673489 yes 110 6.2152490589329e-16 2 4495 A COX2 inhibitor.
SGTC_2683 piperine 63.03 µM 7.99221590906753 0.000161279892072301 yes 111 6.62673307628458e-16 4 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_637 1181-0519 7.26 µM 7.94128624102256 0.000176664431963895 yes 112 1.00047654839465e-15 31 6252091 YGR060W ERG25
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 7.93956383430766 0.000177207972798879 yes 113 1.01446725378012e-15 4 4174840
SGTC_3152 9099253 49.47 µM 7.87580570012637 0.000198464178149256 yes 114 1.6927700785664e-15 36 25236131
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 7.87363216302593 0.000199229172101206 yes 115 1.72245403126085e-15 1 6708561
SGTC_767 0929-0023 86 µM 7.84849775643003 0.000208277856730268 yes 116 2.10525077159378e-15 12 1204563
SGTC_1608 st001473 40.5 µM 7.72204650822014 0.000259917694483601 yes 117 5.72383026715402e-15 7 7292267
SGTC_161 4065-0411 162.148 µM 7.71580352154589 0.000262753174428333 yes 118 6.01111964779934e-15 17 1906281 YLR208W SEC13
SGTC_1757 st041620 31.8375 µM 7.69902591675643 0.000270516811868032 yes 119 6.85536814943063e-15 7 5289815
SGTC_2194 5927483 104.545 µM 7.60447356705255 0.000318415845081751 yes 120 1.43032964540338e-14 4 760979
SGTC_179 1273-0063 6.77 µM 7.59589975570643 0.000323128525614019 yes 121 1.52830542914355e-14 4 3108139
SGTC_1496 4469-0713 57.4 µM 7.58674720323698 0.000328230850697427 yes 122 1.64018098308418e-14 5 746691
SGTC_1191 1487-1166 10.6 µM 7.57693601658823 0.000333783485479507 yes 123 1.76905578890822e-14 4 3955771
SGTC_407 eburnamonine 100 µM 7.56673655149464 0.000339648361999159 yes 124 1.91358474174246e-14 1 3195
SGTC_2455 5377712 9.75 µM 7.49539728376463 0.000383425539111949 yes 125 3.30489249506879e-14 3 2243908
SGTC_495 decylubiquinone 155 µM 7.42857017344182 0.000429132651396062 yes 126 5.48889191056773e-14 1 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1868 st057644 42.7 µM 7.38838174483203 0.000459001510859048 yes 127 7.43132615411039e-14 3 688665
SGTC_1955 wogonin 32.4 µM 7.37658124730681 0.000468131051970221 yes 128 8.12028968728056e-14 1 5281703 A flavanone.
SGTC_1193 1488-0126 41.5 µM 7.34460706316537 0.000493720396299912 yes 129 1.03182225339427e-13 3 1384710
SGTC_1957 st077035 62.4 µM 7.33402881972267 0.000502467433671444 yes 130 1.11667519080345e-13 1 705593
SGTC_1042 0350-0096 82 µM 7.30568121904254 0.000526620038030916 yes 131 1.37932750552538e-13 3 3122515
SGTC_1184 1269-1718 139 µM 7.30423064746998 0.000527884375772058 yes 132 1.39428839368619e-13 3 5403821
SGTC_2741 miltefosine 3.04 µM 7.29105869780238 0.000539494437298957 yes 133 1.53764367995657e-13 15 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1510 1123-0200 71.5 µM 7.28650048082718 0.000543566855333344 yes 134 1.59054828485684e-13 9 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_960 1222-0186 7.7 µM 7.2231768236189 0.000603162249012795 yes 135 2.53934529173091e-13 2 3126296
SGTC_768 0384-0033 77.3 µM 7.19903618115035 0.000627429279551595 yes 136 3.03198301215446e-13 27 3965305 YMR134W ERG29
SGTC_2175 5807670 165.306 µM 7.19902409973307 0.00062744164675355 yes 137 3.03225163778571e-13 4 241186
SGTC_1764 st044502 93.5 µM 7.17096281745388 0.000656781902029813 yes 138 3.72360653964579e-13 4 8407
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 7.14676902530667 0.000683089349553131 yes 139 4.4422090123656e-13 24 442882
SGTC_1671 st016596 74.5 µM 7.14400271010806 0.000686158472434719 yes 140 4.5325806268116e-13 2 2829167
SGTC_1546 5-methoxyflavanone 78.7 µM 7.09509684644011 0.000742561104394545 yes 141 6.46304671760611e-13 2 147795
SGTC_636 0kpi-0074 126 µM 7.05012735511135 0.000798163283945487 yes 142 8.93770546212379e-13 4 616434
SGTC_1752 st044819 83.042 µM 7.03034468664514 0.000823816644822737 yes 143 1.03011970926606e-12 6 441209 YML126C ERG13
SGTC_2993 9054257 71.4286 µM 7.00384615552763 0.000859368121868706 yes 144 1.24514780927162e-12 13 6470217 YGL055W OLE1
SGTC_1160 4092-0570 10.5 µM 6.96918654970548 0.000907998852215671 yes 145 1.59389384608754e-12 9 4994975
SGTC_1649 st011737 51.3 µM 6.96564031114158 0.000913114607175413 yes 146 1.63456707146252e-12 13 1761035
SGTC_1135 dihydrocapsaicin 536.708 nM 6.95245649630797 0.000932366533232132 yes 147 1.7948977827654e-12 3 107982 A Capsaicinoid.
SGTC_2064 5220758 200 µM 6.93120500666908 0.000964185839881964 yes 148 2.08635414619071e-12 6 788518
SGTC_1953 st076800 12.1 µM 6.9243857777891 0.00097460550598553 yes 149 2.18935585060503e-12 7 297591
SGTC_2816 7982706 58.44 µM 6.9130103188157 0.000992217330043619 yes 150 2.37237709590225e-12 10 2981853
SGTC_1597 7-benzyloxygramine 47.5 µM 6.90625129866351 0.00100281971769351 no 151 2.48814073657705e-12 38 260807
SGTC_2300 7976697 71.57 µM 6.89388625970582 0.00102248536813336 no 152 2.71442182374086e-12 11 2236109
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 6.88356379889431 0.00103917276352834 no 153 2.91867182415478e-12 8 6728940
SGTC_1099 5-nonyloxytryptamine 2.85 µM 6.7879377982596 0.00120606875192775 no 154 5.68738344603844e-12 2 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_474 dl-dihydrosphingosine 5 µM 6.7876530438175 0.00120660043676428 no 155 5.69861661952945e-12 7 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_713 1488-1073 324 µM 6.78083032640483 0.00121940393333488 no 156 5.97435709874278e-12 2 3312542
SGTC_961 1252-1571 372 µM 6.77626191462884 0.00122804637620633 no 157 6.16625117384985e-12 4 6813498
SGTC_2524 avocatin b 10.57 µM 6.77091810176729 0.00123822681843862 no 158 6.39838512991128e-12 11 6710748
SGTC_2332 7982454 138.89 µM 6.768552797619 0.00124275754019556 no 159 6.50384606713754e-12 10 2981748
SGTC_2164 5685496 200 µM 6.76180201139146 0.00125577216711267 no 160 6.81429328882481e-12 2 759046
SGTC_1029 k015-0030 64.7 µM 6.74784436776193 0.00128307688600744 no 161 7.50288873477406e-12 4 2208316
SGTC_109 0132-0036 33.701 µM 6.73950183496639 0.00129965515614276 no 162 7.94652942225766e-12 7 67274 A color developer.
SGTC_207 4185-0010 4.486 µM 6.72623551716126 0.00132642168852198 no 163 8.70543371296681e-12 39 3761753
SGTC_2224 6650123 117.647 µM 6.71084921780225 0.00135809607513474 no 164 9.6747486955664e-12 2 2908370
SGTC_1912 st060209 90.8 µM 6.68795592034901 0.00140650492821257 no 165 1.13154637608985e-11 8 688787
SGTC_167 3672-0051 66.205 µM 6.65324415319683 0.00148291583594206 no 166 1.43350996911468e-11 11 3237971
SGTC_2261 9010538 184.68 µM 6.64909702420745 0.00149229383718677 no 167 1.47448281941034e-11 2 6457250
SGTC_2650 prasterone 100 µM 6.63471929975659 0.00152522702730552 no 168 1.62560322384328e-11 12 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1219 1469-0211 33.1 µM 6.58476320445731 0.00164487349991478 no 169 2.27805468276192e-11 8 6822282
SGTC_2721 ifenprodil 61.44 µM 6.58116673445861 0.00165380864919461 no 170 2.33385386532439e-11 6 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_834 0312-0008 75.7 µM 6.56714449291407 0.00168906959797416 no 171 2.56446366095034e-11 15 6385573 YIL048W NEO1
SGTC_1601 4'-hydroxyflavanone 55.5 µM 6.54837004633109 0.00173735250209113 no 172 2.90842209576992e-11 8 165506
SGTC_1837 st055472 66.5 µM 6.53111004335587 0.00178284535683615 no 173 3.26420040867339e-11 3 676091
SGTC_1390 3413-2614 145 µM 6.52791511298433 0.00179138427286404 no 174 3.33457365997726e-11 1 3421432
SGTC_872 0588-0139 234 µM 6.5121502226017 0.00183406541087415 no 175 3.70412868896602e-11 5 2047100
SGTC_2445 5742597 35.57 µM 6.49786927774864 0.0018735249778545 no 176 4.07327709302096e-11 10 1774255
SGTC_1161 k007-0610 110 µM 6.49668583956556 0.00187682930158475 no 177 4.1054336369622e-11 53 5843850
SGTC_3348 9149464 3.537 µM 6.49099224298807 0.00189280077933411 no 178 4.26364351389084e-11 3 1951442
SGTC_932 2857-0803 154 µM 6.48097097583621 0.00192121239257399 no 179 4.55671019366655e-11 5 674898
SGTC_413 propylparaben 100 µM 6.46707725792404 0.00196124400458033 no 180 4.99582864173826e-11 4 7175 A pharmaceutical preservative.
SGTC_1511 0906-3109 28.5 µM 6.42982874415733 0.00207233283375206 no 181 6.38738949770695e-11 10 2882180
SGTC_2102 5377816 72.7585 µM 6.41857934708064 0.00210698794687298 no 182 6.87759541596655e-11 1 1379702
SGTC_2658 polymyxin b sulfate 77.05 µM 6.37400684584753 0.00224952656299067 no 183 9.20761822604461e-11 16 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_879 0831-1030 162 µM 6.34904860700302 0.00233310326278094 no 184 1.083252891225e-10 11 1549252
SGTC_755 1995-0008 37.3 µM 6.31791661715758 0.00244128994368953 no 185 1.32556491242265e-10 4 689533
SGTC_2598 perillyl alcohol 100 µM 6.27548213329893 0.00259606232810215 no 186 1.74276252792681e-10 5 10819 An apoptosis inducer.
SGTC_2689 tacrolimus 100 µM 6.25950427994744 0.00265659954025086 no 187 1.93101568076996e-10 10 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1393 3470-5649 58.2 µM 6.25641723684848 0.00266844170930117 no 188 1.96960998975495e-10 2 4108395
SGTC_2198 6589944 200 µM 6.24663191344184 0.00270629478893807 no 189 2.09698915857686e-10 6 5290268
SGTC_1458 k015-0034 6.33 µM 6.24215480539043 0.00272377492242513 no 190 2.15791742594983e-10 3 3598957
SGTC_864 0469-0573 172 µM 6.20884749232997 0.00285705046057127 no 191 2.66872945436379e-10 2 689425
SGTC_1427 4048-4900 550 nM 6.14792725773095 0.00311611840152529 no 192 3.92510090667919e-10 14 24132586
SGTC_676 falcarinol 140 µM 6.13313824093194 0.0031821177750578 no 193 4.30811065930612e-10 14 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2523 spermine 47.74 µM 6.10487871593848 0.00331174082828747 no 194 5.14393866769839e-10 10 1103 A DNA binding polyamine.
SGTC_176 1486-1328 72.834 µM 6.08542822105247 0.00340369621379276 no 195 5.80901830819529e-10 19 22310231
SGTC_1157 4092-0394 27.6 µM 6.0135837120951 0.00376357059025755 no 196 9.07330764055834e-10 4 3659885
SGTC_2921 7974240 10.71 µM 6.00279510870393 0.00382046248994157 no 197 9.69746527006084e-10 16 2979074 YDR527W RBA50
SGTC_1102 cgs 12066b 26.1 µM 5.99337582470517 0.00387076254247278 no 198 1.02764558104519e-09 3 6438352 A 5-HT1B full agonist.
SGTC_134 0269-0018 6.916 µM 5.97935422507414 0.00394673900745732 no 199 1.12011967386164e-09 84 4378915
SGTC_2486 5283202 22.39 µM 5.97717641866548 0.0039586586159139 no 200 1.13519145467725e-09 10 1377751
SGTC_2003 4023581 200 µM 5.97098528992261 0.00399272032046611 no 201 1.17912504127127e-09 12 16641307
SGTC_621 3584-0052 32.1 µM 5.96813043998831 0.004008515062397 no 202 1.19993741693099e-09 6 2273927
SGTC_826 1683-5028 118 µM 5.96726000209325 0.0040133419638002 no 203 1.2063539400743e-09 5 722377
SGTC_2478 5763493 32.33 µM 5.95175199919071 0.00410021634602607 no 204 1.32643577526427e-09 11 1365576 YLR208W SEC13
SGTC_2122 5258151 111.688 µM 5.92900640139989 0.00423068029679996 no 205 1.52386603700203e-09 7 2173356
SGTC_2213 7173844 200 µM 5.91416342438734 0.00431780595203233 no 206 1.66783285968562e-09 1 892728
SGTC_1726 st035556 14.5795 µM 5.90809425562599 0.00435389044129333 no 207 1.7304399770698e-09 12 5919439
SGTC_1394 3474-0001 65.7 µM 5.90215885153805 0.00438944004063404 no 208 1.79387729665761e-09 14 5017666 YIL048W NEO1
SGTC_2233 sulbentine 40.3845 µM 5.88143531999047 0.00451560423154418 no 209 2.03361942726099e-09 24 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1423 4048-0112 5.59 µM 5.88039503823163 0.00452202194018843 no 210 2.0464424056046e-09 7 X1423
SGTC_1181 1222-0449 220 µM 5.87782353329093 0.00453792103498268 no 211 2.07847855270185e-09 7 658318
SGTC_1857 st056007 79.3 µM 5.87513608167751 0.00455459032053128 no 212 2.11248068781232e-09 2 619834
SGTC_2387 9077560 195.08 µM 5.8540712978038 0.00468715227596838 no 213 2.39841411992256e-09 4 5303272
SGTC_2873 9040596 71.43 µM 5.845636572373 0.00474119035009416 no 214 2.52317356117124e-09 16 6463863
SGTC_2024 5144227 134 µM 5.83164811299599 0.00483203474768706 no 215 2.74412822305891e-09 11 3475211
SGTC_2437 5741531 144.16 µM 5.82720851688386 0.00486118919500523 no 216 2.81810864999133e-09 13 2262990
SGTC_3101 9120531 49.47 µM 5.82552238615727 0.00487230288643515 no 217 2.84671132978015e-09 6 24824904
SGTC_1447 4239-0816 81.9 µM 5.80819618644696 0.00498782264771673 no 218 3.1574747119e-09 3 1341554
SGTC_1548 st061468 90.8 µM 5.80090136614512 0.00503718518224272 no 219 3.29796959818152e-09 2 390799
SGTC_1494 4358-1428 177 µM 5.77701182182022 0.00520189991909517 no 220 3.80194726151309e-09 6 1564571
SGTC_1655 st012546 55.1 µM 5.74722055642435 0.00541401030891807 no 221 4.53611795193196e-09 7 720985 YLR208W SEC13
SGTC_1672 st016598 6.51 µM 5.74721312417914 0.00541406417102586 no 222 4.53631727054078e-09 33 4665860 YNL267W PIK1
SGTC_2268 7933382 153.85 µM 5.73657075633766 0.00549168071587131 no 223 4.83063492479773e-09 11 935025 YOR257W CDC31
SGTC_2411 st077133 39.94 µM 5.73405174460555 0.0055101963713871 no 224 4.90296968718053e-09 8 1403142 YNL221C POP1
SGTC_1056 3448-1962 115 µM 5.72701381245661 0.00556222204268789 no 225 5.11069247689073e-09 5 715507
SGTC_1653 st012112 65 µM 5.69648358282139 0.00579299330433112 no 226 6.11518312397272e-09 2 720429
SGTC_110 0850-0284 111.64 µM 5.68369159876292 0.00589218411715715 no 227 6.59089461513437e-09 6 3906265
SGTC_1921 5740136 50 µM 5.66676122586932 0.00602577943071215 no 228 7.27609532550221e-09 18 1774243
SGTC_669 0108-0021 26.2 µM 5.63133407550773 0.00631404834606333 no 229 8.94104806506122e-09 26 17201
SGTC_1772 st048439 82.2 µM 5.62194518904696 0.00639246324973457 no 230 9.44095894034221e-09 11 2927068 YDL195W SEC31
SGTC_1813 st051246 8.6015 µM 5.59439522321863 0.00662755436772939 no 231 1.1069605924038e-08 3 5291959
SGTC_415 dibenzyl ketone 100 µM 5.5936279014056 0.00663421012921486 no 232 1.11186635857241e-08 3 7593
SGTC_1225 1216-0074 20.6 µM 5.58764986485012 0.00668626637382124 no 233 1.15081554480768e-08 11 4241466
SGTC_2695 st077686 51.995 µM 5.57764631061981 0.00677418433409159 no 234 1.21897354927682e-08 9 2876092
SGTC_368 fentichlor 4.58 µM 5.56303766812805 0.00690440969825573 no 235 1.32559317278258e-08 4 7329 A pesticide.
SGTC_1005 4092-0690 4.4 µM 5.55373377771223 0.00698849480663099 no 236 1.39815628881822e-08 12 1529343
SGTC_2168 5727979 200 µM 5.54262667649332 0.00709005936617332 no 237 1.4898384689705e-08 6 695210
SGTC_2959 9079155 11 µM 5.53831480312368 0.00712983719815668 no 238 1.52697977323923e-08 10 16189457
SGTC_1604 st002052 72.4 µM 5.52830887016914 0.00722290320110928 no 239 1.61666212763259e-08 8 6254834 YHR062C RPP1
SGTC_308 4092-1169 104 µM 5.52309624734506 0.00727180935747722 no 240 1.66538577150814e-08 26 2268590 YDL196W YDL196W
SGTC_526 4469-0568 170 µM 5.51023401804304 0.00739373717554051 no 241 1.79178470636532e-08 20 2901964
SGTC_1112 tnp00069 1.16933 µM 5.49660126867712 0.00752493252793196 no 242 1.93590395285651e-08 5 145826
SGTC_2361 9034121 116 µM 5.48201744199663 0.00766754656280885 no 243 2.10251381437722e-08 4 6496917
SGTC_1838 st055369 84.5 µM 5.479659896108 0.00769082285800008 no 244 2.13072091885501e-08 6 676036
SGTC_2081 5214970 32.255 µM 5.47745604900374 0.00771263789310129 no 245 2.1574206599922e-08 5 2063512
SGTC_2092 5303694 80.6725 µM 5.46185125520711 0.00786866787222332 no 246 2.35597408635481e-08 8 1963699
SGTC_1304 1165-0502 251 µM 5.44134726336139 0.00807790142855765 no 247 2.64395597535056e-08 36 767425
SGTC_1735 st034310 56.75 µM 5.4142660028176 0.00836173875455586 no 248 3.07703114583302e-08 7 871153
SGTC_2665 lovastatin 100 µM 5.41014238945381 0.00840571763789317 no 249 3.14873288004902e-08 3 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1475 4092-1048 11.7 µM 5.40406351128965 0.00847091995954232 no 250 3.25739298368703e-08 12 2881759
SGTC_1173 0443-0020 122 µM 5.39440089331519 0.00857547530313797 no 251 3.43762809299017e-08 16 5331295
SGTC_837 0091-0265 12.5 µM 5.39179672757816 0.00860384691207809 no 252 3.48783261621147e-08 13 759367
SGTC_2210 7115885 190.385 µM 5.39091171686032 0.00861350756834387 no 253 3.50505547375434e-08 13 2927039
SGTC_412 gemfibrozil 100 µM 5.37561474514193 0.00878199716623732 no 254 3.81609138154594e-08 1 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2822 7994718 71.43 µM 5.3648881564292 0.00890186272237293 no 255 4.04996969145906e-08 7 1018011
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 5.32629041155274 0.00934511853906974 no 256 5.01194104563628e-08 9 5355888
SGTC_3243 9134147 49.47 µM 5.30112900525343 0.00964436217709276 no 257 5.7544362577183e-08 1 24282180
SGTC_844 0330-0132 15.3 µM 5.30103901206391 0.00964544731984106 no 258 5.757273904478e-08 5 2828079
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 5.28229936160954 0.00987374843630391 no 259 6.37862575120571e-08 5 4213774
SGTC_23 0213-0011 39.996 µM 5.27242680910601 0.00999591077899611 no 260 6.73157670868089e-08 11 627608
SGTC_343 4130-2827 29.8 µM 5.27092598756745 0.0100145969074228 no 261 6.78686003507919e-08 13 1118244
SGTC_1972 st070201 17.4 µM 5.27063033366787 0.0100182815683171 no 262 6.79780221821124e-08 13 2829099
SGTC_1061 3448-9325 110 µM 5.26732846662767 0.0100595123797592 no 263 6.92117006127175e-08 5 723482
SGTC_3130 9127414 49.47 µM 5.25422960462251 0.0102245418935848 no 264 7.43226749132138e-08 8 1494646
SGTC_1391 3442-0225 151 µM 5.24964841544886 0.0102828140161887 no 265 7.61948898672132e-08 2 5227075
SGTC_668 1682-0499 62.6 µM 5.23961305860863 0.0104114753494704 no 266 8.04568194168621e-08 7 682214
SGTC_2984 9022109 38.96 µM 5.2282180935793 0.0105592671559464 no 267 8.55757742355626e-08 1 6459207
SGTC_1047 2043-3044 82 µM 5.2244046031836 0.0106091343764813 no 268 8.73581865841137e-08 13 669592
SGTC_1119 parthenolide 318.541 nM 5.2177536771259 0.0106965963912193 no 269 9.05530451889793e-08 17 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1750 st081859 2.357 µM 5.20783583684524 0.0108281856141372 no 270 9.552791841032e-08 130 5291695
SGTC_764 1951-2361 146 µM 5.19370719328606 0.0110180760353881 no 271 1.03073639692024e-07 15 5438930
SGTC_1209 2323-2347 50.3 µM 5.19248264831533 0.0110346696442129 no 272 1.03754107708213e-07 5 5412760
SGTC_581 0958-0271 211 µM 5.09840940357685 0.0123761721442362 no 273 1.71259696680705e-07 24 4591145
SGTC_2616 abietic acid 100 µM 5.09781031856482 0.0123851490500966 no 274 1.71802427697403e-07 18 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1654 st012436 41.8 µM 5.09220637790992 0.0124693939939155 no 275 1.76960276985566e-07 2 4323132
SGTC_137 0438-0332 85.389 µM 5.08963919504435 0.0125081523028247 no 276 1.79372721596117e-07 74 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1913 st060213 96.1 µM 5.08393091302164 0.0125947076805092 no 277 1.84851229651389e-07 11 688959
SGTC_3115 9123671 49.47 µM 5.07873123367589 0.0126740017941512 no 278 1.89981889138007e-07 1 3286988
SGTC_1816 st051957 91.6 µM 5.06124976299577 0.0129437669029221 no 279 2.08258575009593e-07 3 674121
SGTC_2267 7931562 200 µM 5.04868395778921 0.0131407301050391 no 280 2.22431987168459e-07 4 934880
SGTC_2786 7743617 45.45 µM 5.04436758850229 0.0132089822668557 no 281 2.27511901690617e-07 7 583674
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 5.04348016464505 0.0132230524648249 no 282 2.28570087810258e-07 20 6710655
SGTC_2818 7996756 12.99 µM 5.0379861098314 0.0133104498387431 no 283 2.35227787332131e-07 8 2241621
SGTC_1303 1160-0052 261 µM 5.02025774073632 0.0135958771017321 no 284 2.58010968139575e-07 2 3562476
SGTC_1131 3454-3128 32.3 µM 5.00886216438463 0.0137821221562435 no 285 2.73763831516441e-07 15 710982
SGTC_1156 4092-0367 4.88 µM 4.99742720537124 0.0139712187705677 no 286 2.90501299938799e-07 5 1357585
SGTC_2673 kobusone 100 µM 4.99347929134214 0.014037021648431 no 287 2.96505734852498e-07 2 6710676 An epoxy ketone and protein crosslinker.
SGTC_2106 5357045 167.29 µM 4.99180641484615 0.014064985224956 no 288 2.9908596366708e-07 7 668842
SGTC_2864 9034755 47.6 µM 4.98507154968322 0.0141780505692665 no 289 3.09694438708105e-07 2 4930451
SGTC_133 0724-0033 378.92 µM 4.9828144248078 0.0142161181155 no 290 3.13330223766221e-07 9 280309
SGTC_963 1269-2853 151 µM 4.97049785789582 0.0144253979771637 no 291 3.33905997054736e-07 14 3668223
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 4.96833527187211 0.0144624165158611 no 292 3.37650657272306e-07 18 23665772 A membrane-active detergent.
SGTC_1594 piperine 70.1 µM 4.94103843689398 0.014936751889595 no 293 3.88537930168726e-07 4 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_285 1486-1325 46 µM 4.92870168752421 0.0151554775245098 no 294 4.13889265575511e-07 14 22310230
SGTC_2627 acetyl isogambogic acid 100 µM 4.92635568109574 0.015197381223914 no 295 4.18887188377806e-07 27 6857789 A caspase activator and apoptosis inducer.
SGTC_517 1365-0151 113 µM 4.92591615005904 0.0152052430630277 no 296 4.19830006144517e-07 18 768657
SGTC_2974 9094440 9.66 µM 4.92572989144328 0.0152085757024616 no 297 4.20230157137282e-07 25 25236134
SGTC_1339 1486-1321 22.7 µM 4.92143327259805 0.0152856274932163 no 298 4.29563474433204e-07 7 3469382
SGTC_2010 4012422 159 µM 4.89529519654829 0.0157616251698292 no 299 4.9079135447197e-07 6 952393
SGTC_2447 5741742 33.78 µM 4.89440660662792 0.0157780281857309 no 300 4.93013938896369e-07 8 1776504
SGTC_981 1488-1094 54.9 µM 4.88977878244092 0.0158636928633537 no 301 5.04746803476091e-07 11 3449522
SGTC_2910 7948405 25.97 µM 4.88525593374479 0.0159477994098129 no 302 5.16472944298373e-07 16 2971328
SGTC_2581 avocatin a 64 µM 4.88016556489389 0.0160429164855954 no 303 5.29984088589643e-07 37 6710728 A skin care supplement.
SGTC_201 4262-0159 12.803 µM 4.87260481316912 0.0161850916232536 no 304 5.50681955452665e-07 26 1341029
SGTC_727 3032-0951 202 µM 4.85581005691738 0.0165047728678646 no 305 5.99477941302501e-07 15 3652836
SGTC_1067 clotrimazole 1.36 µM 4.838413451861 0.0168415938076839 no 306 6.5439832444738e-07 24 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 4.82856101549214 0.0170349445045638 no 307 6.87615989794166e-07 10 6312947
SGTC_1527 coumarin 137 µM 4.76979767024534 0.0182279938986674 no 308 9.22055252864229e-07 5 323 A hepatotoxic, DNA x-linker.
SGTC_2785 7756463 72.73 µM 4.76761561402444 0.0182736331273796 no 309 9.32095105850417e-07 12 2201551
SGTC_3104 9120930 49.47 µM 4.75502645230358 0.0185388497840349 no 310 9.92102176156058e-07 4 17014836
SGTC_2678 equilin 100 µM 4.75471077368229 0.0185455421084229 no 311 9.9365356994718e-07 13 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1372 2752-0194 270 µM 4.74361167469272 0.0187821518315585 no 312 1.04970560325174e-06 11 823334
SGTC_3317 9138495 8.753 µM 4.74142606403824 0.0188290459830794 no 313 1.06109552553797e-06 22 17020139
SGTC_2401 5128683 200 µM 4.73757559798754 0.0189119033866995 no 314 1.08145090884745e-06 18 708373
SGTC_2056 5235370 200 µM 4.72204508114869 0.0192492569315067 no 315 1.16742455268504e-06 28 5511916
SGTC_2015 5119600 184 µM 4.71897199113328 0.0193166132106126 no 316 1.18519725237692e-06 17 2828786
SGTC_2669 eugenol 100 µM 4.71545790505986 0.0193938806417237 no 317 1.20583876058975e-06 6 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_638 3970-0837 4.09 µM 4.65728975843285 0.0207115185386504 no 318 1.60199673941867e-06 21 4118451 YLR208W SEC13
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 4.6485374218792 0.0209161956230543 no 319 1.67148488660224e-06 6 688667
SGTC_530 4358-1714 28 µM 4.64416965150055 0.0210189765165934 no 320 1.70723453608909e-06 26 1564641
SGTC_1782 st039423 80.636 µM 4.63575993736349 0.0212180749838827 no 321 1.77814254269651e-06 10 2068169
SGTC_1674 st016616 23.6 µM 4.62823785814027 0.0213975080833723 no 322 1.84395149925833e-06 15 625830
SGTC_1865 st057639 52.2 µM 4.62711642562949 0.0214243685224379 no 323 1.85396047360591e-06 4 688818
SGTC_2717 st081029 62.2815 µM 4.62409990261525 0.0214967614777941 no 324 1.88114258702613e-06 10 5292846
SGTC_2034 5197015 53.07 µM 4.60468371999133 0.0219676919489004 no 325 2.06546597006323e-06 14 780676
SGTC_1982 st072467 71.9 µM 4.60127334859016 0.0220513018118841 no 326 2.09957961042261e-06 19 3163533
SGTC_178 4092-0806 87.505 µM 4.59395533165009 0.0222316198243582 no 327 2.17461257399725e-06 66 2169044
SGTC_3184 9108758 49.47 µM 4.59064368491161 0.022313627730291 no 328 2.20940568430594e-06 3 902885
SGTC_3134 9127454 49.47 µM 4.58415222850745 0.022475119325964 no 329 2.27916033703473e-06 8 24262820
SGTC_2174 5790901 200 µM 4.58218676770982 0.0225242091549416 no 330 2.30069320781447e-06 29 786020
SGTC_2464 5717415 7.67 µM 4.52138920757603 0.0240879582222594 no 331 3.07175560278896e-06 6 5285744
SGTC_959 1222-0044 107 µM 4.50710362369247 0.0244683413761865 no 332 3.28592715833485e-06 11 6083612
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 4.49194078574218 0.0248775863970606 no 333 3.52885243925013e-06 15 688664
SGTC_1864 st057645 30.4 µM 4.48746749149101 0.0249994115427595 no 334 3.6037402755012e-06 3 688666
SGTC_1840 st055363 71 µM 4.47932716724719 0.0252223874049452 no 335 3.74393452653469e-06 6 676033
SGTC_784 4579-0127 173 µM 4.4743439982449 0.025359704550281 no 336 3.83231308101558e-06 11 1948547
SGTC_2118 5526350 200 µM 4.45185768226744 0.0259871543993814 no 337 4.25652916861493e-06 6 743594
SGTC_1409 3909-8004 61.9 µM 4.43217781572772 0.0265469010428509 no 338 4.66430172008067e-06 5 2119279
SGTC_2852 9023854 51.95 µM 4.42887179171687 0.0266419141520083 no 339 4.73636551395594e-06 23 19798528
SGTC_2620 irigenin 100 µM 4.41238223412529 0.0271200654109724 no 340 5.11197041493896e-06 22 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1774 st048371 48.465 µM 4.3968173355835 0.0275779529618478 no 341 5.49248572418941e-06 9 4242727
SGTC_2353 9059630 146.67 µM 4.39659787624837 0.0275844547973937 no 342 5.49803942684567e-06 17 4779114
SGTC_2331 7980721 200 µM 4.38210183994959 0.0280167615451875 no 343 5.8769920212782e-06 17 2981221
SGTC_890 0929-0006 47.2 µM 4.38047430110844 0.0280656490859667 no 344 5.92106295275284e-06 13 1378169
SGTC_1779 st039427 55 µM 4.38001163685252 0.028079559420661 no 345 5.9336485655009e-06 14 1124498
SGTC_1748 st037455 53.6035 µM 4.37332535827459 0.0282812289922784 no 346 6.11840709518477e-06 19 580690
SGTC_1474 0330-0125 5.35 µM 4.37145632629011 0.0283378172946343 no 347 6.17102699988422e-06 19 X1474
SGTC_3255 9139072 49.47 µM 4.34541587061688 0.0291360888115781 no 348 6.95060217526034e-06 7 17646060
SGTC_821 1114-0266 29.2 µM 4.32775340118694 0.0296880965472923 no 349 7.53189947260566e-06 16 3123235
SGTC_3286 9117135 37.221 µM 4.32191923112155 0.0298723285663349 no 350 7.73389076191458e-06 6 3438150
SGTC_1833 st055984 71 µM 4.30737941609843 0.0303355981800858 no 351 8.26000509342474e-06 12 676288
SGTC_3258 9138477 49.47 µM 4.30145018323617 0.030526217562143 no 352 8.48419627013265e-06 4 4970355
SGTC_577 r071-0003 38.6 µM 4.29224266815786 0.0308241965969819 no 353 8.84387424400439e-06 44 4568517 YMR134W ERG29
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 4.2894360435027 0.0309155036412354 no 354 8.95636928286126e-06 42 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_14 0354-0009 295 µM 4.28460248817951 0.0310732768694882 no 355 9.15331027231387e-06 23 1713507
SGTC_542 3381-0244 89.3 µM 4.27614478621475 0.031350949203198 no 356 9.50787889950358e-06 31 1112843
SGTC_2594 a-mangostin 100 µM 4.27448298952883 0.0314057476272093 no 357 9.57906652121623e-06 23 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1850 st056238 17 µM 4.25192022296921 0.0321576324056426 no 358 1.05972682894506e-05 14 5393177
SGTC_2508 celastrol 40.54 µM 4.24818247586212 0.0322836129118399 no 359 1.07755913359038e-05 16 122724 Celastrol is a natural product and antioxidant.
SGTC_1416 3966-0321 25.3 µM 4.24000250373785 0.0325607397138984 no 360 1.11758646769274e-05 7 582530 YLR208W SEC13
SGTC_1024 4507-0395 26 µM 4.22670075727626 0.0330155732556377 no 361 1.18571349442944e-05 21 4201836
SGTC_2322 7413319 38.22 µM 4.20993687306824 0.0335962333103952 no 362 1.27721025632542e-05 140 1840400
SGTC_2396 5342950 42.78 µM 4.19747651704668 0.0340332537922968 no 363 1.34952817052694e-05 35 1886677
SGTC_79 0052-0007 94.094 µM 4.18640512488372 0.034425471355644 no 364 1.41703657803312e-05 35 2801472
SGTC_1618 st003135 44.5 µM 4.18027860316768 0.0346441022925409 no 365 1.45576080137186e-05 12 1270615
SGTC_677 0929-0063 136 µM 4.1786441127708 0.0347026230016579 no 366 1.46626075893351e-05 12 1539583
SGTC_278 4092-0821 23.9 µM 4.16727417033196 0.0351119584437283 no 367 1.54131826653953e-05 37 877900
SGTC_3020 9089140 49.47 µM 4.16155402599197 0.035319385583697 no 368 1.58044597454176e-05 23 17217859
SGTC_3151 9099821 49.47 µM 4.14583483478643 0.0358945843984482 no 369 1.69288913846437e-05 12 17174189
SGTC_556 4058-0063 51.5 µM 4.11158671875856 0.0371743881195066 no 370 1.96474613910157e-05 23 6615692
SGTC_2238 6671620 73.2395 µM 4.1004737624116 0.0375975893273691 no 371 2.06152591410266e-05 26 729941
SGTC_1628 st004252 77.7 µM 4.09721398316919 0.0377224710277939 no 372 2.09076168109841e-05 18 692968
SGTC_501 nsc-95397 161 µM 4.09560153432333 0.0377843687721337 no 373 2.10536814880246e-05 13 262093
SGTC_1004 4084-0029 199 µM 4.07953145401414 0.0384057985385293 no 374 2.25632819453405e-05 12 716894 YLR208W SEC13
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 4.07284333445914 0.0386668715307498 no 375 2.32213326870167e-05 28 688664
SGTC_298 1391-0729 10 µM 4.07222442084145 0.0386911039513751 no 376 2.32831396862214e-05 18 3237558
SGTC_237 nikkomycin 200 µM 4.05572867935032 0.0393415366621399 no 377 2.49891239263403e-05 11 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2377 9073351 62.6 µM 4.04658551420623 0.039705869992708 no 378 2.59850722944599e-05 22 7337946 YHR072W ERG7
SGTC_2498 4'-Methoxychalcone 54.63 µM 4.0427992888034 0.0398575431170192 no 379 2.64084151884159e-05 34 641818 YHR062C RPP1
SGTC_1933 st074711 15.9 µM 4.03563063501081 0.0401460034311876 no 380 2.72279148171671e-05 41 17250958
SGTC_1279 0874-0590 65.2 µM 4.02602009828984 0.0405353815477632 no 381 2.8364421139721e-05 30 3523074
SGTC_2528 xanthyletin 44.79 µM 4.02519392543019 0.040568997176724 no 382 2.84641909161506e-05 22 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2833 9001315 45.46 µM 4.02137372325892 0.0407247293322684 no 383 2.89298613868532e-05 52 2989378
SGTC_1461 k072-0203 53.8 µM 4.01132667230252 0.0411366181975595 no 384 3.01892483735645e-05 9 5418714
SGTC_543 3844-1095 191 µM 4.00031137034794 0.0415920765672546 no 385 3.16295970091412e-05 49 4230703
SGTC_1189 1431-2119 7.28 µM 3.97758416928532 0.042544706100396 no 386 3.48094913863282e-05 26 3107275
SGTC_657 3534-0529 86.7 µM 3.95143984068157 0.043662308373298 no 387 3.88412006401904e-05 12 1049549
SGTC_680 0417-1641 114 µM 3.95123863157683 0.0436710005252878 no 388 3.88738759774246e-05 14 2835990
SGTC_1418 3966-3099 2.4 µM 3.94981767004245 0.0437324252455608 no 389 3.91053738532555e-05 19 740335
SGTC_2948 9070189 9.45 µM 3.94368976772589 0.0439981185305419 no 390 4.01187217375096e-05 45 6473636 YDL196W YDL196W
SGTC_869 0564-0080 44.1 µM 3.9387466186829 0.0442133905733752 no 391 4.09541871786792e-05 23 6843321
SGTC_1302 1159-0335 255 µM 3.92789934084123 0.044688760929905 no 392 4.28455299113809e-05 15 649284
SGTC_2458 5808907 16.39 µM 3.91891528950091 0.0450855862833781 no 393 4.44741834142657e-05 6 2731747
SGTC_1974 st069448 26.9 µM 3.90821316292721 0.0455619947133413 no 394 4.64906263885415e-05 25 6323587 YNR016C ACC1
SGTC_1435 4092-0789 56.7 µM 3.89497177886397 0.0461570318966919 no 395 4.91050818073841e-05 13 2248285
SGTC_971 1315-0384 26.7 µM 3.89065640203373 0.0463522979392892 no 396 4.99867068879864e-05 24 6769120
SGTC_1954 st077032 68.9 µM 3.88844576878067 0.0464525832391942 no 397 5.04441031425294e-05 22 698907
SGTC_1190 1486-1332 13 µM 3.88463868282976 0.0466256997348988 no 398 5.12410909341724e-05 13 4150046
SGTC_19 0279-0214 38.434 µM 3.88266421723303 0.0467156866469743 no 399 5.16590977747781e-05 39 3566274 YBR002C RER2
SGTC_428 3448-4153 16.5 µM 3.8821323673889 0.0467399496831217 no 400 5.17722427387097e-05 33 3834874
SGTC_1998 st075797 76.8 µM 3.87290913796604 0.0471623242642353 no 401 5.37719646729064e-05 18 24208315
SGTC_2352 9027995 87.8 µM 3.86207331744763 0.0476624498840128 no 402 5.62144062637554e-05 33 2997347
SGTC_1937 st074714 47.2 µM 3.86142057398888 0.0476927122823511 no 403 5.63648300335478e-05 43 17250970
SGTC_2422 chlorphenesin carbamate 384.24 µM 3.85939250878142 0.0477868353363146 no 404 5.68346207511198e-05 27 2724 A muscle relaxant with antifungal properties.
SGTC_2181 6316240 54.2555 µM 3.84667101925286 0.0483806403778577 no 405 5.98667826813355e-05 21 12779990
SGTC_2600 tangeritin 87.95 µM 3.84656590392394 0.0483855713511529 no 406 5.98924607707339e-05 34 68077 A bioactive flavone.
SGTC_2820 7989630 71.43 µM 3.83584412106379 0.0488906466668521 no 407 6.25668796296317e-05 27 2984098
SGTC_807 1315-0151 48 µM 3.82710850811761 0.0493052656642073 no 408 6.48286842085361e-05 32 4011080
SGTC_405 ebelactone b 50 µM 3.82532649957733 0.0493901890497676 no 409 6.52994424891839e-05 20 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_227 fluconazole 33.516 µM 3.80308768858402 0.050459852633981 no 410 7.14518719346099e-05 92 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_943 3253-1379 105 µM 3.79540324288566 0.0508337285521606 no 411 7.37018376802634e-05 27 668464
SGTC_603 3794-0023 45.9 µM 3.79331870426029 0.0509355282482752 no 412 7.43235853902184e-05 14 3802260
SGTC_2710 st078562 53.7235 µM 3.79259239018211 0.0509710363324915 no 413 7.45413780883281e-05 23 17250908
SGTC_2651 TUB2.036 5 µM 3.79154481137831 0.0510222851260027 no 414 7.48565638234574e-05 172 15992207 YFL037W TUB2
SGTC_208 k072-0098 12.366 µM 3.78610739739286 0.0512889490635152 no 415 7.65127792745007e-05 49 5948901
SGTC_3156 9099931 49.47 µM 3.78597328832165 0.0512955400803432 no 416 7.6554060980591e-05 10 18111053
SGTC_2727 riluzole 51.77 µM 3.77525520585686 0.0518244807789986 no 417 7.99219649889804e-05 16 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1172 0370-0043 85 µM 3.75893238920725 0.0526383342171359 no 418 8.53199690243232e-05 27 376585
SGTC_843 0310-0051 143 µM 3.75603558604918 0.0527838225145013 no 419 8.63130790137098e-05 15 2065037
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 3.75309676836666 0.0529317467549734 no 420 8.7331695398487e-05 11 4620898
SGTC_845 0330-0138 4.51 µM 3.74481389838319 0.0533504315056442 no 421 9.02637709220273e-05 23 9039800
SGTC_901 1112-0062 60.1 µM 3.73202625805556 0.0540019738857506 no 422 9.49728479006174e-05 13 1908457
SGTC_1848 st056003 16.4 µM 3.73013070519087 0.0540990878934296 no 423 9.56902318462778e-05 24 146492
SGTC_470 aa-861 153 µM 3.7292803023336 0.0541427010929266 no 424 9.60137242879204e-05 64 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1531 st059297 52.4 µM 3.71830671467185 0.054707984901782 no 425 0.000100281332444171 22 7566702
SGTC_1166 k206-0078 225 µM 3.71334256569961 0.0549652318182205 no 426 0.000102269861893149 26 5404595
SGTC_1623 st003709 20.3 µM 3.70006771776346 0.05565784415029 no 427 0.000107770971910863 87 16192618
SGTC_3284 9108171 64.8615 µM 3.69097252622992 0.0561363471969709 no 428 0.000111699134395824 32 8687505
SGTC_2588 indole-3-carbinol 100 µM 3.68001382477492 0.0567171929423028 no 429 0.000116610654701819 56 3712 Induces cell cycle arrest.
SGTC_10 0279-0212 42.575 µM 3.66529627920035 0.0575047056991823 no 430 0.000123526202951044 145 39851 YBR002C RER2
SGTC_3196 9111891 49.47 µM 3.66458957829387 0.0575427354960411 no 431 0.000123867762213391 29 18891510
SGTC_2956 9076196 2.52 µM 3.65306976467521 0.0581654463824828 no 432 0.000129561895695836 30 16423868
SGTC_1561 5-methoxyflavone 52.9 µM 3.65107412823494 0.0582738578475114 no 433 0.000130572923113667 10 94525
SGTC_585 0kpi-0023 191 µM 3.65048568123903 0.0583058550764247 no 434 0.000130872450790509 25 64601
SGTC_465 cgp-37157 41 µM 3.64761449726521 0.058462175754612 no 435 0.000132343185646941 16 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1100 amiodarone 5.07 µM 3.64743760745108 0.0584718172151789 no 436 0.000132434300481589 24 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_738 1315-0003 72.4 µM 3.64589538830127 0.0585559294842452 no 437 0.000133231183073737 34 6251474
SGTC_204 PMA1.184 62.41 µM 3.64375149612988 0.058673014644329 no 438 0.000134346426928396 42 2252213 YGL008C PMA1
SGTC_763 3453-1109 128 µM 3.64354648644559 0.0586842205326425 no 439 0.000134453529287027 29 1560353
SGTC_2091 4-phenylthiadiazole 200 µM 3.64227676096961 0.058753661520033 no 440 0.000135118651642177 24 270010
SGTC_697 0508-1955 564 µM 3.63176825386964 0.0593308475174934 no 441 0.000140742925103584 49 6243113
SGTC_662 k832-1615 104 µM 3.62289816385839 0.0598214943619358 no 442 0.000145660268580966 29 5878478
SGTC_2499 avocadenofuran 51.48 µM 3.60298028874566 0.0609348262431452 no 443 0.000157294696482684 52 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1285 0929-0069 65.5 µM 3.59898268169298 0.0611602166251779 no 444 0.000159732230381718 27 1206237
SGTC_1130 3454-2858 15.9 µM 3.58863193246288 0.0617468332487285 no 445 0.000166208880131568 107 715628 YIL048W NEO1
SGTC_1934 st074720 32.6 µM 3.57560828471514 0.062491162873724 no 446 0.000174707254440368 72 17250992
SGTC_3307 9126885 69.2785 µM 3.56822021322844 0.0629165062805422 no 447 0.00017970718750672 43 24824909
SGTC_1708 st033234 31.827 µM 3.55816231921352 0.0634991769079665 no 448 0.000186729256100703 25 674664
SGTC_1526 st051518 75 µM 3.54806774890639 0.0640881861859408 no 449 0.000194034194151115 31 673993
SGTC_2897 9048598 12.99 µM 3.54018512552909 0.0645510768243652 no 450 0.000199923224392907 27 6467404
SGTC_435 c-PAF 6.7 µM 3.53896959678162 0.0646226867618642 no 451 0.000200846057084246 65 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2360 9040895 200 µM 3.52653882480954 0.0653585621086204 no 452 0.000210514715011568 28 4914414
SGTC_194 1486-1323 56.904 µM 3.51732450486455 0.0659082126934172 no 453 0.000217960250224748 32 5178754
SGTC_1770 st043884 66.3 µM 3.51028551559965 0.0663305091478025 no 454 0.000223812884921694 25 670149
SGTC_24 0417-1663 219 µM 3.5053567142012 0.0666274522901698 no 455 0.000227997938624095 29 4329390
SGTC_2602 kawain 100 µM 3.50143326656025 0.0668645609966456 no 456 0.000231381424542664 40 5369129
SGTC_2938 9059746 27.26 µM 3.48993884135485 0.0675629707921251 no 457 0.00024156554989282 55 6471769
SGTC_365 0121-0052 13.6 µM 3.48706988623964 0.0677381666210683 no 458 0.000244171864304219 79 3101739
SGTC_3280 9140961 49.47 µM 3.48560750105936 0.0678276036674003 no 459 0.000245510442207401 28 4901226
SGTC_2719 novobiocin 32.65 µM 3.47777175539906 0.068308379210901 no 460 0.000252800124087829 8 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1158 4092-0494 91.8 µM 3.47588778095543 0.0684243649010613 no 461 0.00025458264637812 27 1148199
SGTC_583 1488-1091 88.9 µM 3.47416662526425 0.0685304595188299 no 462 0.000256221352631105 32 4303273
SGTC_2314 7727897 200 µM 3.46573037900853 0.0690523186004984 no 463 0.000264396638091446 36 900724
SGTC_71 0417-1750 47.813 µM 3.44241902041112 0.0705102652739741 no 464 0.000288268225555919 72 6811472
SGTC_2696 st077691 74.316 µM 3.44025880333151 0.0706465593590461 no 465 0.000290579088023237 40 757133
SGTC_296 1222-0039 74.9 µM 3.43668704605861 0.0708723554491789 no 466 0.000294437795126221 24 5984176
SGTC_2186 6124449 200 µM 3.43350554573189 0.0710739471174213 no 467 0.000297915007413705 35 3834182 YLR033W RSC58
SGTC_17 0960-0276 49.807 µM 3.43019738550633 0.0712840311260868 no 468 0.000301571160886537 61 6821114
SGTC_1738 st035555 74 µM 3.42051985772352 0.0719013377159324 no 469 0.000312507862565075 55 5331140
SGTC_1373 2887-0003 58.5 µM 3.41572894186611 0.0722084519866532 no 470 0.000318057659573691 37 776948
SGTC_87 0100-0052 35.5 µM 3.41511033777917 0.0722481798267157 no 471 0.000318780896396859 159 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2318 6029776 164 µM 3.4095104112227 0.0726085794781481 no 472 0.000325397969151676 53 818325
SGTC_1329 1447-1697 50.6 µM 3.40873381341781 0.0726586682282358 no 473 0.00032632564541253 29 2840515
SGTC_2376 9072922 81.32 µM 3.40558586333928 0.0728619747418408 no 474 0.000330111242086728 55 17087968
SGTC_2557 derrustone 83.84 µM 3.40105305771708 0.0731554851124718 no 475 0.000335633988199005 55 629853 An antioxidant.
SGTC_1477 0139-0234 16 µM 3.39925788283016 0.0732719769033552 no 476 0.000337844871236286 20 620880
SGTC_2854 9024559 71.43 µM 3.39831680911043 0.0733331013613707 no 477 0.000339009270875463 44 3163529
SGTC_205 1486-1330 71.903 µM 3.3904908732831 0.07384292198342 no 478 0.000348837887572676 29 4118834
SGTC_2189 6047310 154.431 µM 3.37231131803343 0.0750376795240281 no 479 0.000372700701879125 31 711535
SGTC_1237 0330-0133 46.1 µM 3.36765039660287 0.0753463562084625 no 480 0.000379058319959633 38 X1237 YHR072W ERG7
SGTC_338 4055-0136 114 µM 3.35117951748562 0.0764449220146788 no 481 0.000402340598670206 24 2900563
SGTC_420 mitomycin C 81.9 mM 3.34867237181829 0.0766132054763835 no 482 0.000405998766493694 29 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1335 1486-0900 202 µM 3.34174125499075 0.077079898768117 no 483 0.000416273150316222 55 X1335
SGTC_1259 0671-0132 43 µM 3.31979596283352 0.0785717947490327 no 484 0.000450416306357487 49 X1259
SGTC_574 1315-0397 40 µM 3.31941129205459 0.0785981394520692 no 485 0.000451037299807682 70 6794277
SGTC_59 0330-0160 1.33 µM 3.31839608460491 0.0786676994695343 no 486 0.000452680013073566 165 4293482
SGTC_3173 9105693 49.47 µM 3.31421505692753 0.0789546670516365 no 487 0.000459503971928915 47 17096658
SGTC_2154 5570129 200 µM 3.30743511413307 0.0794216973118855 no 488 0.00047077260595469 45 673366
SGTC_702 1488-0190 94 µM 3.29759438896494 0.0801032824996201 no 489 0.000487584460756833 33 949357
SGTC_559 1550-0661 158 µM 3.29429141749668 0.0803330402420359 no 490 0.000493350722121864 25 5830875
SGTC_1732 st034308 51.822 µM 3.29172790236538 0.0805117036849178 no 491 0.000497869504380876 54 830119
SGTC_2701 st077767 14.721 µM 3.29163909328536 0.0805178985832094 no 492 0.000498026735295928 75 5721188
SGTC_119 0121-0043 24.815 µM 3.27978050671928 0.0813483352077001 no 493 0.000519439386131852 164 1092378
SGTC_639 0833-0042 114 µM 3.27866356616402 0.0814268843536192 no 494 0.000521499501470955 80 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_875 0709-0210 25.7 µM 3.26679592167853 0.0822650157566143 no 495 0.000543860302882905 57 6251364
SGTC_1978 st071761 42 µM 3.26633157790005 0.0822979408034129 no 496 0.000544752977948835 30 5147680
SGTC_2160 5660466 132.927 µM 3.26457642679243 0.0824224822829056 no 497 0.000548139413877324 38 2859134
SGTC_2113 5491891 107.031 µM 3.26241261117982 0.0825762168974487 no 498 0.000552341132096075 51 789979
SGTC_1389 3405-0187 19 µM 3.25679052281848 0.0829766634608129 no 499 0.000563397775092061 36 799890
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.25373681766409 0.0831947821227116 no 500 0.000569488732938594 93 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1706 st031321 9.9705 µM 3.24608663974795 0.0837431080912687 no 501 0.00058501612734852 24 6103185
SGTC_3038 9091290 49.47 µM 3.24569420209317 0.0837713090617411 no 502 0.00058582310193622 42 25236843
SGTC_1252 0493-0875 34.8 µM 3.22488460729162 0.0852769464394038 no 503 0.00063011726710314 56 3960963
SGTC_2676 harmalol 100 µM 3.22033272410987 0.0856089749396802 no 504 0.000640209464350272 34 5459187 A monoamine oxidase inhibitor
SGTC_2055 5235184 200 µM 3.21916580993361 0.0856942489617952 no 505 0.000642820605673593 67 2836034
SGTC_2551 apiole 73.87 µM 3.21887772690497 0.0857153108498263 no 506 0.000643466744858997 24 10659 A possible DNA adduct former.
SGTC_918 glabranin 770.725 nM 3.21219889698199 0.0862046903011128 no 507 0.000658615730839708 65 124049 Also referred to as licorice root.
SGTC_523 1934-0222 13.7 µM 3.19570942231692 0.0874218726201304 no 508 0.000697437566428121 61 1361595
SGTC_1376 2910-0861 41.3 µM 3.19315784174215 0.0876113598163681 no 509 0.00070363000602665 52 1112859
SGTC_1284 0929-0043 16 µM 3.19087117683254 0.087781433901615 no 510 0.000709222553027917 58 1239883
SGTC_2821 7996764 71.43 µM 3.18586974364465 0.0881542811034853 no 511 0.000721597793147981 76 2987135
SGTC_3198 9112019 49.47 µM 3.17747444767376 0.0887827862116971 no 512 0.000742818902716087 40 45595555
SGTC_1297 1068-0111 14.1 µM 3.16017681850175 0.0900882650822302 no 513 0.000788367096291174 30 767057
SGTC_91 0417-1751 58.384 µM 3.16017098926458 0.0900887074148245 no 514 0.000788382870138572 94 6795624
SGTC_371 0195-0006 7.36 µM 3.15555595182433 0.0904394109854859 no 515 0.000800962688837426 45 3928593
SGTC_719 2810-4230 27.3 µM 3.15392140412461 0.0905638654863968 no 516 0.000805462321707626 15 721079
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 3.14874323220718 0.0909589709400564 no 517 0.000819871006222684 46 5393153
SGTC_1080 nisoldipine 24.4 µM 3.13624475409127 0.0919178968725811 no 518 0.000855631621286908 58 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1164 k060-0068 93.7 µM 3.13396145442511 0.0920938853008685 no 519 0.000862317546118202 65 5963676
SGTC_2132 5317594 122.667 µM 3.13026003218158 0.0923797072586744 no 520 0.000873258139737107 46 794577
SGTC_3169 9102970 49.47 µM 3.12806015983032 0.0925498910074263 no 521 0.000879820802318136 17 17027839
SGTC_1165 k072-0275 30.3 µM 3.12170709353667 0.093042670843239 no 522 0.000899028674854975 77 6153523 YGL055W OLE1
SGTC_1003 4049-0218 100 µM 3.11781351591151 0.0933456357694143 no 523 0.000910990238930522 58 295161
SGTC_1214 0358-0031 63.7 µM 3.11709619556394 0.0934015309189975 no 524 0.000913209827377715 48 4301366
SGTC_2345 9052315 157.45 µM 3.11393555048622 0.0936481096902641 no 525 0.000923049052275984 57 6469265
SGTC_792 4534-1957 155 µM 3.11180282702181 0.0938147661976087 no 526 0.00092974324828948 71 1717904
SGTC_862 0452-0056 10.2 µM 3.11029599602333 0.0939326457662377 no 527 0.000934499748345167 58 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2330 7979373 200 µM 3.10919866981502 0.0940185584887794 no 528 0.0009379776510622 72 1863007
SGTC_958 1222-0007 33 µM 3.10724087653981 0.094171983556886 no 529 0.000944212292121407 61 7312461
SGTC_3223 9129970 49.47 µM 3.0970118630389 0.0949765980640993 no 530 0.000977410253707834 53 17248386
SGTC_1691 st019933 84.6 µM 3.09431679048891 0.0951894330618205 no 531 0.00098633364135541 44 6176082
SGTC_3350 9150499 3.57 µM 3.09212897820649 0.0953624668714584 no 532 0.000993632417153391 97 4910996 YPR165W RHO1
SGTC_476 mead acid 10 µM 3.08514678113397 0.0959162365673262 no 533 0.00101725860498032 17 5312531 An omega 9 fatty acid.
SGTC_1951 sophoraflavanone G 9.2 µM 3.08379736780241 0.0960235329520343 no 534 0.00102188372967419 71 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2424 5537928 59.2 µM 3.08257302308469 0.0961209610552487 no 535 0.00102609686700306 82 5382802
SGTC_3318 9139014 38.6185 µM 3.07579503194761 0.0966616396326888 no 536 0.00104971055653538 44 16643984
SGTC_2086 5274770 176.623 µM 3.05670540062879 0.0981964141980506 no 537 0.00111892049307916 67 689278
SGTC_3140 9094243 49.47 µM 3.05629303464116 0.0982297635814241 no 538 0.00112046064192779 64 19291112
SGTC_2894 9048625 32.47 µM 3.04876288556131 0.0988402110079066 no 539 0.00114892884446505 45 4092861
SGTC_1336 1486-0901 104 µM 3.04298575826394 0.0993104243771677 no 540 0.0011712170940646 51 5006114
SGTC_700 3453-2283 142 µM 3.04189957777503 0.0993990133985143 no 541 0.00117545155427714 72 565664
SGTC_2050 5263056 171 µM 3.03999483131635 0.0995545042159298 no 542 0.00118291104354612 95 763468 YGL055W OLE1
SGTC_966 1300-0360 30.2 µM 3.0388659119258 0.0996467455358865 no 543 0.00118735262090746 62 70588
SGTC_3182 9108849 49.47 µM 3.02697456661775 0.100622154634647 no 544 0.00123507370483914 42 17133045
SGTC_2317 5986382 200 µM 3.00730121860927 0.102251158181546 no 545 0.00131789222513789 45 877883
SGTC_1667 st014849 34.6 µM 3.00561684979733 0.102391514595472 no 546 0.00132521369153366 30 5348460
SGTC_473 2-arachidonoylglycerol 10 µM 3.0035084307457 0.10256740398269 no 547 0.001334430771722 53 5282280 An endocannabinoid.
SGTC_2565 isoliquiritigenin 100 µM 2.99712537236272 0.10310123290215 no 548 0.0013626930199176 72 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2141 5621638 7.665 µM 2.98951893920197 0.103740006865136 no 549 0.00139708562348595 63 2856238
SGTC_2553 4-methylesculetin 85.09 µM 2.98340115430098 0.104255846420049 no 550 0.0014253204832504 74 5319502
SGTC_950 1165-0508 94.1 µM 2.97390241092808 0.105060441757928 no 551 0.00147019287099485 69 6148369
SGTC_2269 7935389 174.42 µM 2.96301356911222 0.105988303853565 no 552 0.0015232156968059 58 97605
SGTC_1991 st073000 8.92 µM 2.96052547830571 0.106201148127344 no 553 0.00153557359102306 136 4301969 YIL048W NEO1
SGTC_3063 1327-0034 4 µM 2.9596123887692 0.106279335964193 no 554 0.00154013162613906 81 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_850 0388-0143 75.9 µM 2.95900322680777 0.106331521604496 no 555 0.00154317934810453 54 67273
SGTC_2838 9002687 71.43 µM 2.95718166619975 0.106487681315461 no 556 0.00155232570793002 71 6457060
SGTC_386 1509-0011 3.07 µM 2.95404399133175 0.106757057684076 no 557 0.00156819646693738 204 3107280
SGTC_126 0417-1624 672.48 µM 2.94177051886928 0.107815486015138 no 558 0.00163170832588235 89 41912 YDL195W SEC31
SGTC_947 3447-0010 211 µM 2.93216553904873 0.108649047901404 no 559 0.00168303636388191 58 748350
SGTC_1970 st070122 35.8 µM 2.93068180897057 0.108778224638197 no 560 0.0016910950804103 79 102928
SGTC_1666 st014829 29 µM 2.93029833441841 0.10881162871117 no 561 0.00169318358592387 64 3858230
SGTC_2062 5245942 200 µM 2.92995452882819 0.108841583531819 no 562 0.00169505803990027 63 1376160
SGTC_1202 1988-0068 29.6 µM 2.92691356230025 0.109106792620186 no 563 0.00171172006338264 77 2850480
SGTC_903 1134-0042 114 µM 2.92409740857545 0.109352809197129 no 564 0.00172728312244706 71 701009
SGTC_3145 9085516 49.47 µM 2.92038809937846 0.109677458743546 no 565 0.00174797860351456 86 25236195
SGTC_2751 anetholtrithion 17.25 µM 2.91700534191416 0.109974130274466 no 566 0.00176704860031563 81 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2430 5571206 200 µM 2.90332360662504 0.111179906975125 no 567 0.00184612449781737 109 1731771
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.89518369727907 0.111901756103659 no 568 0.00189468353721452 77 1377
SGTC_828 2074-0507 139 µM 2.89059512445629 0.112310145938492 no 569 0.00192256571463207 74 X828
SGTC_3089 9117425 49.47 µM 2.88635285174886 0.11268866104708 no 570 0.00194867472302263 79 9401657
SGTC_1222 0366-0074 1.18 µM 2.88351673531599 0.112942219975227 no 571 0.00196630875167833 58 286520
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.88114939597632 0.113154180179763 no 572 0.00198113891523134 61 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1053 3366-3204 134 µM 2.87359980568411 0.113832029687709 no 573 0.00202911415463002 90 3632071 YPR165W RHO1
SGTC_456 gingerol 170 µM 2.87226291707851 0.113952364888583 no 574 0.00203771873756144 71 442793 A herb.
SGTC_1111 tnp00062 510.699 nM 2.86459193809494 0.114644592587448 no 575 0.00208773462775273 47 676306
SGTC_74 000s-0487 160.283 µM 2.85671440359426 0.115358568814991 no 576 0.00214025399552851 67 677548
SGTC_1043 0916-0009 19.3 µM 2.84851157256605 0.116105380790123 no 577 0.0021962127934313 85 3101130
SGTC_812 4251-0442 148 µM 2.83981205063106 0.116901155729213 no 578 0.0022570060559955 41 5723007
SGTC_3192 9110362 49.47 µM 2.83941417461147 0.116937643023619 no 579 0.00225982257195817 48 16649480
SGTC_1213 1315-0166 115 µM 2.8360544411436 0.117246069863755 no 580 0.00228373297666514 84 768401
SGTC_389 tpck 16.7 µM 2.82738114804796 0.118044949259381 no 581 0.00234652163490839 80 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3016 9080866 49.47 µM 2.82688458882706 0.118090802562137 no 582 0.00235016323861677 81 17066299
SGTC_375 3970-0961 9.27 µM 2.81408311808142 0.119277267714615 no 583 0.00244582892868555 83 2898222
SGTC_1759 st043059 70 µM 2.80955549027032 0.119698904222456 no 584 0.00248049830898958 81 669426
SGTC_1472 k841-0093 193 µM 2.80636171995302 0.119996956440609 no 585 0.00250522061823517 75 X1472
SGTC_2123 5259487 200 µM 2.8048264555886 0.120140417931054 no 586 0.00251718388579481 76 2173474
SGTC_210 3551-0445 56.827 µM 2.80315515908595 0.120296728182097 no 587 0.00253026585642859 113 2865180 YOR207C RET1
SGTC_429 1112-0049 25.5 µM 2.80197792219673 0.120406916808872 no 588 0.00253951746658664 104 2836170
SGTC_3154 9100113 49.47 µM 2.79031502913669 0.12150239791853 no 589 0.00263283892744889 91 25237525
SGTC_935 2996-0153 430 µM 2.78537788419166 0.121968242155097 no 590 0.00267326871822126 80 23738523
SGTC_2694 st077685 81.9 µM 2.78001010300191 0.122476140832791 no 591 0.00271786036490321 98 2838096
SGTC_846 0335-0850 148 µM 2.77884733065938 0.122586357468533 no 592 0.00272760787846184 84 6819598
SGTC_113 0099-0221 2.5 µM 2.75854903877486 0.124521604999789 no 593 0.00290292966995066 94 89219
SGTC_2552 juarezic acid 87.02 µM 2.75693510948564 0.124676389267104 no 594 0.00291729644923074 111 1549512
SGTC_349 k015-0014 24 µM 2.75433051373481 0.124926467166744 no 595 0.00294061711696106 94 2196908
SGTC_666 0272-0154 136 µM 2.75173157086317 0.125176351392792 no 596 0.0029640545257486 129 6870312
SGTC_3257 9139206 32.98 µM 2.74770618222807 0.125564074696209 no 597 0.00300068811969962 32 4910041
SGTC_337 1315-0038 354 µM 2.74541471901096 0.125785161149272 no 598 0.00302172362199756 83 1626437
SGTC_748 act1.228 77.9 µM 2.74519741627864 0.125806141180758 no 599 0.00302372532884088 160 4421505 YNR035C ARC35
SGTC_1575 cyproterone acetate 48 µM 2.74310888940724 0.126007907655449 no 600 0.00304302501125921 89 9880 An androgen receptor antagonist and liver toxin.
SGTC_290 2043-6722 48.1 µM 2.74286549023457 0.126031436408992 no 601 0.00304528142091605 74 773758 YLR208W SEC13
SGTC_886 0866-0150 153 µM 2.74027968464803 0.126281588526792 no 602 0.00306934610881034 90 271463
SGTC_673 1082-0474 110 µM 2.73831561889502 0.12647182430417 no 603 0.00308773889747018 160 3098046
SGTC_2428 5615643 7.78 µM 2.73354579249604 0.126934651763928 no 604 0.003132820506908 85 2253075
SGTC_1652 st011932 78 µM 2.73281160807491 0.127005995970222 no 605 0.00313981196380395 74 1551076
SGTC_1245 0418-0076 17.2 µM 2.73039388814114 0.127241134618943 no 606 0.00316293470158053 90 6790114
SGTC_1231 0242-0792 125 µM 2.71604123686669 0.128643256281687 no 607 0.00330338442027892 90 3707635
SGTC_2674 ligustilide 100 µM 2.71504010331503 0.128741456249271 no 608 0.00331338726331491 50 5319022 A signalling regulator.
SGTC_779 1360-0071 233 µM 2.70767506142815 0.129465482877281 no 609 0.00338781627951193 112 7566
SGTC_813 k007-0158 173 µM 2.70375166641211 0.129852325139951 no 610 0.00342807536683903 129 6523916
SGTC_2425 5628681 7.85 µM 2.70165862688667 0.130059023479423 no 611 0.00344972801295853 103 5714958
SGTC_758 0868-0029 16 µM 2.6990896777222 0.130313031456882 no 612 0.00347647187858334 59 762687
SGTC_2271 7849410 118.62 µM 2.69472425090689 0.13074545502521 no 613 0.003522345217909 72 972430
SGTC_929 2805-0021 398 µM 2.68946572851683 0.131267661189669 no 614 0.00357832475975572 83 3098024
SGTC_259 usnic acid 108.925 µM 2.68942072055043 0.131272136987476 no 615 0.00357880731905944 89 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2138 5575593 77.673 µM 2.68783410709616 0.131429984422574 no 616 0.00359585579062914 62 762213
SGTC_2316 5844804 197.44 µM 2.68529213493237 0.131683150696323 no 617 0.00362332176492816 125 776813
SGTC_682 0kpi-0099 17 µM 2.67772673837581 0.132438612386219 no 618 0.00370618320740643 152 1714895 YML126C ERG13
SGTC_1075 aripiprazole 15.2 µM 2.67038857050491 0.133174231912278 no 619 0.00378817569092921 126 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3238 9133470 49.47 µM 2.6696869111304 0.133244717222325 no 620 0.00379610018825317 61 3534688
SGTC_2286 7945697 125 µM 2.66838206566209 0.133375863938019 no 621 0.00381087655774442 139 1245733
SGTC_450 aminopyrene 156 nM 2.66824113434214 0.13339003389978 no 622 0.00381247557744401 116 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.66217620897655 0.134000814159398 no 623 0.00388186120183875 76 229346 A bile salt which induces apoptosis.
SGTC_312 4092-0653 6.84 µM 2.66149115971875 0.134069923990539 no 624 0.00388976918715984 177 1148278
SGTC_548 1436-0017 110 µM 2.6610501068806 0.134114431684598 no 625 0.00389486819258952 124 9677137
SGTC_3030 9087619 49.47 µM 2.65910751740616 0.134310583824215 no 626 0.0039173977908152 83 25236973
SGTC_1569 carminic acid 40.6 µM 2.65801729978458 0.134420754350569 no 627 0.00393009290659492 81 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1286 0929-0070 131 µM 2.65762811459918 0.134460097978284 no 628 0.00393463371935922 101 1420408
SGTC_1519 esterone 74 µM 2.65338304839067 0.134889754945172 no 629 0.0039844690288909 99 698 A steroid.
SGTC_646 4092-0839 27.3 µM 2.64944938794772 0.135288733406346 no 630 0.00403115235486338 81 877796
SGTC_1478 0453-0656 35.7 µM 2.6458935537375 0.135650085657745 no 631 0.00407377251983326 69 5258496
SGTC_2077 5212015 200 µM 2.63999185830618 0.136251288068128 no 632 0.00414540094744885 138 780900
SGTC_1136 pergolide 1.05886 µM 2.63094679842301 0.137176237198016 no 633 0.00425736820248593 155 47811 A dopamine receptor agonist.
SGTC_2395 5646831 180.19 µM 2.63081528406488 0.137189717435614 no 634 0.00425901595126081 110 6808628
SGTC_2662 daunorubicin 22.37 µM 2.62918028352308 0.137357380742173 no 635 0.00427954860263801 87 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3292 9120825 59.784 µM 2.62627560136571 0.137655590224078 no 636 0.00431624452802274 89 24824900
SGTC_689 0833-0039 98 µM 2.6206314953057 0.138236305618079 no 637 0.00438835376280796 91 5374726
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.62004089046435 0.13829716863763 no 638 0.00439596121133579 104 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1264 0783-0040 158 µM 2.61998093676021 0.138303348008828 no 639 0.00439673411995031 106 2855798
SGTC_1471 k673-0312 37 µM 2.61385060158632 0.138936189497339 no 640 0.00447640875326117 67 24099884
SGTC_459 nigericin 15.3 µM 2.61127141414949 0.139203030294336 no 641 0.00451031350768014 147 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1452 4194-0072 190 µM 2.60690573693361 0.139655494327567 no 642 0.0045682254189091 94 1343545
SGTC_1863 st057641 20.1 µM 2.60488124493435 0.139865654125991 no 643 0.00459530543645977 90 3921635
SGTC_2216 7189485 200 µM 2.60329617525718 0.140030348043437 no 644 0.00461660755889704 37 731273
SGTC_430 0958-0115 16.4 µM 2.60261908874725 0.140100739693769 no 645 0.00462573391414811 123 6833180
SGTC_2795 7780010 54.55 µM 2.59888899049048 0.140488961262852 no 646 0.00467630064543594 108 953673
SGTC_2960 9079389 5.97 µM 2.59173402588907 0.141235678829627 no 647 0.00477467838293517 121 16457355
SGTC_2814 7977482 42.97 µM 2.59156922347004 0.141252909839079 no 648 0.00477696592909552 159 6456762
SGTC_2772 vinpocetine 57.06 µM 2.58957417144507 0.141461616676392 no 649 0.00480473594740829 101 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1337 1486-1011 40.3 µM 2.58644075823042 0.14178983167011 no 650 0.00484864193278756 86 X1337
SGTC_2476 5806916 10.51 µM 2.58248565598278 0.142204851745014 no 651 0.00490457198636359 87 2870194
SGTC_2664 lyso-paf C-16 73.48 µM 2.58180144669559 0.142276731083465 no 652 0.00491430567344309 94 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2405 ticlatone 3.52 µM 2.57656162481768 0.142828013478034 no 653 0.00498942080467428 169 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_596 1155-0152 116 µM 2.57213187497918 0.143295192897907 no 654 0.00505371914792141 147 280313
SGTC_2444 5485484 36.41 µM 2.56875535349418 0.143651986921631 no 655 0.00510322422618609 131 6790631
SGTC_2680 butyl paraben 22.24 µM 2.5670323149802 0.14383428971402 no 656 0.00512865264440151 72 7184 An antifungal and steroid mimetic.
SGTC_736 0958-0254 92.6 µM 2.56043351967463 0.144533905642307 no 657 0.00522708314522614 127 6812352
SGTC_1785 bathophenanthroline 24 µM 2.55620999590201 0.144982892482058 no 658 0.00529096181860722 157 72812 An iron chelator.
SGTC_1421 4029-0249 71.4 µM 2.55396513353818 0.145221917059335 no 659 0.00532519604400786 95 2894095
SGTC_3060 1327-0027 12.5 µM 2.54447723955512 0.146235080045407 no 660 0.00547207219319465 103 16000455 YPR107C YTH1
SGTC_1928 4'-methoxychalcone 40.3 µM 2.5418500474793 0.146516461469759 no 661 0.00551337346457128 72 641818
SGTC_63 0099-0242 26.702 µM 2.53797340318449 0.146932326944811 no 662 0.00557482287735054 210 3898502 YLR359W ADE13
SGTC_41 0478-0632 82.643 µM 2.52823392302534 0.14798061578585 no 663 0.00573189715737455 143 3750424
SGTC_1429 4049-0205 9.46 µM 2.52644335999761 0.148173882780464 no 664 0.00576119832224974 97 22774478
SGTC_2193 5925765 200 µM 2.51886188698777 0.148994070788835 no 665 0.00588674140286561 63 877370
SGTC_1996 st072960 66.8 µM 2.5112677733862 0.149818661312853 no 666 0.00601492036303134 94 1719405
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.50919846406226 0.150043879550662 no 667 0.00605027386411935 54 88881 An O-methylated flavonoid and antioxidant.
SGTC_40 0327-0103 19.753 µM 2.5013448066357 0.150900704356118 no 668 0.00618613273869907 124 409036
SGTC_1155 4088-0394 48.2 µM 2.4951582571173 0.151577938452414 no 669 0.00629504822743005 122 2326248
SGTC_709 3807-1509 243 µM 2.49201813203294 0.151922455999731 no 670 0.00635097764428413 80 1886677 YPL242C IQG1
SGTC_2402 5553605 200 µM 2.48758797166661 0.152409393228285 no 671 0.00643063203519419 136 6758546
SGTC_2991 9074669 71.4286 µM 2.48616791407952 0.152565696614266 no 672 0.0064563511287277 172 17333109
SGTC_2416 tofa 880 nM 2.48535543452324 0.152655172709759 no 673 0.00647110708491997 149 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1574 spiramycin 23.7 µM 2.47427992964078 0.15387835824311 no 674 0.00667525220204947 137 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_710 3448-4187 58 µM 2.47333840264692 0.15398263937908 no 675 0.00669286628552383 209 3946412
SGTC_3059 1327-0034 3 µM 2.46918240278205 0.154443505995039 no 676 0.00677110851126882 155 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_616 4092-0450 108 µM 2.46796010857289 0.15457922184416 no 677 0.00679427309694227 113 787165
SGTC_2219 9098279 200 µM 2.46309310943426 0.155120404329348 no 678 0.00688720700574786 74 902349
SGTC_3356 9151811 4.48 µM 2.46250909918876 0.15518542688545 no 679 0.0068984335997188 115 1859254 YPR165W RHO1
SGTC_2630 antimycin a 100 µM 2.46174270599141 0.155270782896534 no 680 0.00691319070913653 147 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1122 capsaicin 818.572 nM 2.45876483778081 0.155602733024883 no 681 0.0069707952835041 133 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1305 1181-0477 144 µM 2.45550261165042 0.155966918106212 no 682 0.0070343865240354 114 6252086
SGTC_975 1335-0046 28.5 µM 2.44335044217435 0.157328490342161 no 683 0.00727579974264473 161 16486740
SGTC_95 0471-0001 561.058 µM 2.44225070787895 0.157452092888359 no 684 0.00729800320574918 134 4015405
SGTC_1437 4092-1038 11.6 µM 2.43918482522447 0.15779701382384 no 685 0.00736021860750864 116 3977136
SGTC_334 1502-1024 68.5 µM 2.43551152526634 0.158210924010479 no 686 0.0074353754293947 116 3296216
SGTC_718 1130-0073 349 µM 2.42806981021341 0.159051643919434 no 687 0.0075897105734636 122 6740020
SGTC_3324 9138759 60.749 µM 2.42321589449087 0.159601584248149 no 688 0.00769189054253035 115 45595710
SGTC_2067 5224629 34.075 µM 2.42037395691211 0.159924147824304 no 689 0.00775227665288712 134 2835000
SGTC_18 0111-0177 500 nM 2.41961454805677 0.160010413848486 no 690 0.00776848320806765 211 721752
SGTC_1417 3966-0327 90.4 µM 2.41050759249095 0.161047300227208 no 691 0.00796516987281662 130 651118
SGTC_1635 st007035 42.4 µM 2.40467689448749 0.161713460568637 no 692 0.00809338506664896 380 3716403
SGTC_2893 9048488 25.97 µM 2.39981778579532 0.16226998628224 no 693 0.00820161741848277 118 6467338
SGTC_1278 0874-0585 172 µM 2.39843585377347 0.162428489828393 no 694 0.00823263005997395 117 766306
SGTC_1179 1021-1431 9.29 µM 2.38834875015795 0.163588501847065 no 695 0.00846213651929667 188 2840958
SGTC_2187 6125751 200 µM 2.3799124074036 0.164562797689196 no 696 0.00865837687640644 125 874498
SGTC_2731 amoxapine 43.43 µM 2.37943189555466 0.164618403975845 no 697 0.00866967338410924 39 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1381 2324-0066 62.1 µM 2.37912735984549 0.164653652073257 no 698 0.00867683950195001 166 10885928
SGTC_86 0417-1630 471.922 µM 2.37165953958364 0.165519535474867 no 699 0.00885419987533356 316 3634867
SGTC_651 3253-0966 34.4 µM 2.36742327526093 0.166012031340922 no 700 0.00895621680540458 150 781462
SGTC_1552 6-methylflavone 10.6 µM 2.36169023676144 0.166680044115698 no 701 0.00909591779869146 96 689013
SGTC_158 k038-0087 26.446 µM 2.35148571216176 0.167873359028409 no 702 0.00934930386311771 300 X158
SGTC_2355 9061122 103.12 µM 2.3502950003719 0.168012958055483 no 703 0.00937926872877689 102 5302957
SGTC_390 dec-rvkr-cmk 16.7 µM 2.35009072808588 0.168036914440195 no 704 0.00938441777791575 164 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3015 9080845 49.47 µM 2.34813923761997 0.168265889659224 no 705 0.00943373336916255 101 5296973
SGTC_550 4123-0385 25.7 µM 2.34311272643632 0.168856591611574 no 706 0.00956180209022972 151 5731123
SGTC_777 1315-0167 517 µM 2.34007532334862 0.16921418397781 no 707 0.00963992552580932 138 4221767
SGTC_1251 0490-5699 265 µM 2.33940486142198 0.169293182675158 no 708 0.00965724508787989 167 3883818
SGTC_5 0352-0601 109.883 µM 2.33426756883883 0.169899281334521 no 709 0.00979085789375226 95 762456
SGTC_1843 st055809 45.5 µM 2.32488911103867 0.171009336696836 no 710 0.0100389451898057 134 16413835
SGTC_248 streptozotocin 5.23457 mM 2.31996166961368 0.171594414650821 no 711 0.0101714754789235 146 5300 DNA alkylating agent.
SGTC_974 1326-0144 138 µM 2.30858584559671 0.172950043322151 no 712 0.0104832870676947 182 5411856
SGTC_991 3996-0057 64.7 µM 2.30644564122596 0.173205846775065 no 713 0.0105428721021576 134 715343
SGTC_294 k038-0071 157 µM 2.3030369065191 0.17361376586418 no 714 0.0106383833321686 211 24152826
SGTC_2340 7987427 183.45 µM 2.30147049608583 0.17380142109764 no 715 0.010682525600381 159 2239331
SGTC_1466 k213-0079 57.5 µM 2.29706122162984 0.174330342484828 no 716 0.0108076387627674 144 3657981
SGTC_711 k292-0785 179 µM 2.2966861329579 0.174375383982139 no 717 0.0108183405376402 144 4146315
SGTC_1292 0kpi-0043 232 µM 2.29626782553131 0.174425624004577 no 718 0.0108302862793471 135 3333905
SGTC_2517 totarol 10 µM 2.29320644966561 0.17479358460526 no 719 0.0109180610044727 138 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3172 9105863 49.47 µM 2.28209615934168 0.176133115549322 no 720 0.0112418318531431 53 2348785
SGTC_1834 st055981 52.8 µM 2.27851526846767 0.176566232744664 no 721 0.0113479479270828 161 471719 YDL150W RPC53
SGTC_1983 st071813 46.9 µM 2.27776957926277 0.176656510278174 no 722 0.0113701548483733 138 11838595
SGTC_3032 9089427 49.47 µM 2.27535701668936 0.176948789256609 no 723 0.0114422608316308 133 17173707
SGTC_279 1273-0055 2.93 µM 2.27030802019831 0.177561457249117 no 724 0.0115944503919199 179 2847562
SGTC_987 1497-1013 404 µM 2.2655546172385 0.178139478566371 no 725 0.0117393331988574 113 1676435
SGTC_605 1315-0399 119 µM 2.26378457116064 0.178355021704466 no 726 0.0117936839632782 165 24020461
SGTC_1402 3909-7673 35.9 µM 2.26033798925647 0.178775192264275 no 727 0.0119001409638658 151 5328014
SGTC_1326 1431-2094 10.8 µM 2.25990092625355 0.178828518815848 no 728 0.0119137002125467 176 616278
SGTC_1192 1488-0095 21.4 µM 2.25105937710379 0.179909435528362 no 729 0.0121908884424332 143 915875
SGTC_1749 st037932 54.2 µM 2.24567882488388 0.180569234782258 no 730 0.0123622937278156 163 594497
SGTC_462 ag-879 158 µM 2.24411447685424 0.1807613499831 no 731 0.0124125183713771 184 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2204 7233102 200 µM 2.23765469370797 0.181556022478502 no 732 0.0126217909537971 98 2172480
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.23524187395743 0.181853403837355 no 733 0.0127007368956483 184 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2071 5230951 39.92 µM 2.23093815137122 0.18238459587772 no 734 0.0128426130729099 151 1799272
SGTC_1028 k015-0029 4.8 µM 2.2293997360432 0.182574711565194 no 735 0.0128936598932646 200 4588309
SGTC_1349 flufenamic acid 69 µM 2.2274960265354 0.182810141175086 no 736 0.0129570705363998 148 3371 A non-steroidal anti-inflammatory.
SGTC_684 1140-0066 328 µM 2.22430758645178 0.183204876229985 no 737 0.0130638783185065 204 6813534
SGTC_146 3448-8650 53.125 µM 2.22239105086671 0.183442402650863 no 738 0.0131284448008066 349 2891488 YIL048W NEO1
SGTC_2016 5121758 140 µM 2.21996041500819 0.183743920228025 no 739 0.0132107274111246 227 2795203
SGTC_2623 humulene 100 µM 2.21651365676578 0.184172015598173 no 740 0.0133281718148962 125 6187145 An anti-inflammatory.
SGTC_1439 4092-1168 46 µM 2.21575412746498 0.184266434304957 no 741 0.0133541728343566 132 2886240
SGTC_1125 tnp00248 1.32998 µM 2.21550096242647 0.184297912482882 no 742 0.0133628491794731 244 24207736
SGTC_1002 4049-0206 172 µM 2.20865011967601 0.185151006498709 no 743 0.0135994931869423 221 4662749
SGTC_593 1203-0218 61.7 µM 2.2081452971086 0.185213965877468 no 744 0.0136170731238718 158 3666956
SGTC_2284 7945075 39.21 µM 2.1964260784044 0.186679273263236 no 745 0.0140307303897318 197 1245402
SGTC_1765 st044815 90.4 µM 2.18895353712109 0.187617335604767 no 746 0.0143001086189409 172 645695
SGTC_1420 4'-methoxyflavone 42 µM 2.18406085196223 0.188233111632225 no 747 0.0144788884269926 146 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1670 st016595 4.04 µM 2.18159109285904 0.188544419832907 no 748 0.0145698624229071 161 597879
SGTC_3334 9142812 21.919 µM 2.17702920755744 0.189120270516719 no 749 0.0147391941397981 171 45283678
SGTC_2032 5185112 25.99 µM 2.17016994661262 0.189988156977532 no 750 0.0149969869467602 148 5718189
SGTC_3138 9097216 49.47 µM 2.1690718403032 0.190127324824529 no 751 0.0150386150992427 156 25237486
SGTC_3268 9137683 49.47 µM 2.16799288626345 0.190264126416754 no 752 0.015079613895644 110 1953228
SGTC_2484 5809818 12.04 µM 2.1644756224834 0.190710503280378 no 753 0.0152139327628075 162 2870548
SGTC_1299 1079-1439 3.74 µM 2.15754808006919 0.191591557094819 no 754 0.0154814925631231 157 323161
SGTC_2018 5133068 143 µM 2.15688523783713 0.191675988723394 no 755 0.0155073037159342 198 785362
SGTC_497 capsazepine 133 µM 2.15384242780386 0.192063868611303 no 756 0.0156262655795309 163 2733484 A calcium channel blocker.
SGTC_1020 4335-0961 93.3 µM 2.15299217265752 0.192172340035921 no 757 0.0156596468513417 169 669075
SGTC_1084 voriconazole 435 nM 2.14919838212296 0.19265678994148 no 758 0.0158093387443665 169 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1768 st044301 37.178 µM 2.14497792258061 0.193196599636567 no 759 0.0159773061046419 178 3931349
SGTC_2815 7968870 71.43 µM 2.1447637801319 0.193224013699261 no 760 0.0159858692488003 214 2977326 YHR190W ERG9
SGTC_1442 4112-3290 3 µM 2.14339637716485 0.193399121710425 no 761 0.0160406418795617 178 704353
SGTC_2182 6325192 200 µM 2.14120795831525 0.193679569442335 no 762 0.0161286357774314 147 736248
SGTC_2732 terfenadine 20 µM 2.13296822287496 0.194737721150665 no 763 0.0164636665278565 128 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3067 9117431 49.47 µM 2.13264700617717 0.194779043086104 no 764 0.0164768470914327 149 17150885
SGTC_908 3448-7491 47.7 µM 2.13242912813609 0.194807074372967 no 765 0.0164857924753118 345 1203031
SGTC_387 norethindrone acetate 66.7 µM 2.1289057720558 0.195260715377836 no 766 0.01663102856928 161 541197
SGTC_1629 st005085 44.9 µM 2.12708576000348 0.195495297745725 no 767 0.0167064791110617 224 24207091
SGTC_3110 9122132 49.47 µM 2.12541329065322 0.195711014087189 no 768 0.0167760711251956 161 918317
SGTC_89 0302-0250 142.109 µM 2.11766387006338 0.196712424553283 no 769 0.0171017723946355 206 4203518 YLR208W SEC13
SGTC_485 niflumic acid 177 µM 2.11758026795316 0.196723244838694 no 770 0.0171053153761765 158 4488 A COX2 inhibitor.
SGTC_904 1141-0088 396 µM 2.11414819980332 0.197167754733136 no 771 0.0172513057610809 186 1378119
SGTC_479 n-linoleoylglycine 10 µM 2.11306618093105 0.197308020071816 no 772 0.0172975518945422 132 6433346 An anti-infammatory.
SGTC_729 4092-0585 94.1 µM 2.11047044955906 0.197644758473591 no 773 0.0174089269433714 189 2169061
SGTC_1180 1193-0155 285 µM 2.10579166535764 0.198252603295346 no 774 0.0176112265702509 185 2921347
SGTC_696 1560-0013 611 µM 2.09976028339025 0.199037833697149 no 775 0.0178749668155235 191 1650269
SGTC_3351 9150312 21.596 µM 2.09437726693419 0.199740233066778 no 776 0.0181131931056451 212 4904905
SGTC_3092 9117248 49.47 µM 2.0916903007852 0.200091397318922 no 777 0.0182331143564538 111 17141857
SGTC_909 3448-9333 149 µM 2.08973630346682 0.200347001525693 no 778 0.0183207469856043 167 3344074
SGTC_2188 6126565 140.678 µM 2.08137042587985 0.201443565654089 no 779 0.0187000067391033 144 874518
SGTC_2851 9015922 71.43 µM 2.07653301475121 0.202079271136014 no 780 0.0189223404696873 214 2996893
SGTC_2518 prenyletin 46.28 µM 2.0762001677342 0.20212305612606 no 781 0.0189377208908506 106 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2681 menadione 3.18 µM 2.07578450437597 0.202177743318544 no 782 0.0189569430761934 193 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1205 4161-2785 76 µM 2.07437913109249 0.202362708304373 no 783 0.0190220569532924 203 3498106
SGTC_2949 9072542 2.23 µM 2.07324226823198 0.202512407922909 no 784 0.0190748692526942 252 16457352
SGTC_1241 0364-0022 50.8 µM 2.07295524629478 0.202550212809451 no 785 0.0190882223838188 220 4563895
SGTC_735 3076-0345 636 µM 2.07279031948526 0.202571937933133 no 786 0.0190958988743475 239 2888990
SGTC_1676 st018489 23.4 µM 2.06957838341873 0.202995310575103 no 787 0.0192459220433803 242 3696235
SGTC_346 4513-0042 7.16 µM 2.06851513345019 0.203135576314535 no 788 0.0192958045255095 231 2827372
SGTC_1258 0671-0043 57.1 µM 2.06516095739889 0.203578443925105 no 789 0.0194538866508272 239 4298767
SGTC_569 4130-2812 160 µM 2.06458074432684 0.203655110557724 no 790 0.0194813433750047 127 743552
SGTC_271 rotenone 740 µM 2.06230291877845 0.203956258156834 no 791 0.0195894526623151 227 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_100 0086-0128 49.5915 µM 2.05398291495705 0.205058484810289 no 792 0.0199886726689852 266 93297
SGTC_148 3253-0744 288.01 µM 2.04963934493425 0.205635320994981 no 793 0.0201998190007362 197 6893655
SGTC_1939 st074455 53.6 µM 2.04293819063189 0.206527136663069 no 794 0.0205292785703889 235 1644229
SGTC_2990 9074105 71.4286 µM 2.04099248553379 0.206786507221289 no 795 0.0206257870093088 169 6502001
SGTC_262 fenpropimorph 62.5 µM 2.03734493677662 0.207273259881414 no 796 0.0208077438188843 197 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1631 benzylvanillin 81.9 µM 2.03692797176375 0.207328945528535 no 797 0.0208286302838364 235 75506
SGTC_2135 5326629 150.42 µM 2.03622188405895 0.207423263659913 no 798 0.0208640398590998 202 5020077
SGTC_509 pifithrin 175 µM 2.03601117077469 0.207451415336126 no 799 0.0208746167824244 145 4817 A p53 inhibitor.
SGTC_1624 st003710 6.25 µM 2.02409891340057 0.209046584344424 no 800 0.0214799877041511 267 24207033
SGTC_3245 9134821 49.47 µM 2.02045495049404 0.209535986051606 no 801 0.0216681092473732 229 17014901
SGTC_2240 6690706 185.951 µM 2.02038534142817 0.209545341438787 no 802 0.0216717163595453 176 805876
SGTC_2925 9010536 32.5 µM 2.0188397212194 0.209753134502456 no 803 0.0217519405361465 289 2994177
SGTC_1557 sumaresinolic acid 42.3 µM 2.01862810155389 0.209781594060364 no 804 0.0217629439855185 215 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2133 5320837 200 µM 2.01713629777143 0.20998228289676 no 805 0.021840645808959 208 2841355
SGTC_1947 st076332 61.6 µM 2.01498639962261 0.21027170197561 no 806 0.0219530370630076 158 24208416
SGTC_3158 9100007 49.47 µM 2.0144758005022 0.210340473187331 no 807 0.0219798015415115 174 19297233
SGTC_2906 7926292 26.41 µM 2.01434347624418 0.210358297737455 no 808 0.0219867421800858 229 2966319
SGTC_2952 9073731 13.78 µM 2.0101323415515 0.210926015667141 no 809 0.0222085919481456 270 16457353
SGTC_192 3455-0609 60.9 µM 2.00665178833533 0.211395918702281 no 810 0.0223933764303801 199 3769639
SGTC_1068 loratadine 26.9 µM 2.00577262227693 0.211514710205269 no 811 0.0224402564542811 216 3957 A H1 histamine antagonist.
SGTC_2097 5376186 200 µM 2.00553376046649 0.211546991579605 no 812 0.0224530076404184 240 742755
SGTC_1282 0886-0010 32.4 µM 2.00003015181417 0.212291584432506 no 813 0.0227485040716744 249 2836211 YNL267W PIK1
SGTC_3276 9139060 49.47 µM 1.99680358435986 0.212728823692613 no 814 0.0229232620296989 150 4870619
SGTC_57 miconazole 162.5 nM 1.99596316154553 0.212842797489864 no 815 0.0229689663753563 207 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1871 st057448 67.3 µM 1.99512429591704 0.212956595644938 no 816 0.0230146625552971 242 691747
SGTC_2973 9094665 17.96 µM 1.99305351585881 0.213237663801301 no 817 0.0231277936607368 270 25237061 YIL048W NEO1
SGTC_2295 7971645 200 µM 1.98876675051347 0.213820195844966 no 818 0.023363477180149 225 2978226 YKL099C UTP11
SGTC_1753 st043925 64 µM 1.98675077580482 0.214094468370153 no 819 0.0234750109707931 210 670181
SGTC_985 1493-0307 8.71 µM 1.98638484971407 0.214144274408878 no 820 0.0234953037886042 164 3278274
SGTC_3335 9143315 29.6265 µM 1.98332063528933 0.214561607818286 no 821 0.0236658129320487 208 4899691
SGTC_3160 9100216 49.47 µM 1.98228980543017 0.214702108815988 no 822 0.0237234071840442 167 17191039
SGTC_1216 1165-0504 9.65 µM 1.97893750836476 0.215159392776576 no 823 0.0239115212828844 226 6304004
SGTC_2872 9044037 25.97 µM 1.96821196534492 0.2166262474848 no 824 0.0245218270540492 142 6465195
SGTC_3113 9123498 49.47 µM 1.9623346612192 0.217432491029242 no 825 0.0248617671596925 173 8897275
SGTC_384 k007-0144 5.16 µM 1.96032426296442 0.217708672873963 no 826 0.0249789509353855 289 6824886
SGTC_3131 9127911 49.47 µM 1.95673935034359 0.218201658183575 no 827 0.0251890604610821 241 45595681
SGTC_2841 9004761 38.96 µM 1.95145770023251 0.218929143979987 no 828 0.0255013116849316 222 2991039
SGTC_786 4544-0069 423 µM 1.95117309105487 0.218968385156873 no 829 0.0255182294206475 258 748821 YLR208W SEC13
SGTC_1021 4476-0760 85.3 µM 1.95073844260773 0.219028321166267 no 830 0.025544083924697 250 746768
SGTC_1777 st045864 34.765 µM 1.94599147832036 0.21968351949627 no 831 0.0258278816296434 214 4691462
SGTC_2912 7964298 10.93 µM 1.93753412969479 0.220853626740852 no 832 0.026340042785055 337 2975850
SGTC_545 4218-0007 221 µM 1.93248830860512 0.221553432000126 no 833 0.026649631856338 239 2840508
SGTC_742 0kpi-0133 140 µM 1.93163162569476 0.221672371141571 no 834 0.0267024947443389 248 2728852
SGTC_1048 3161-0300 24.5 µM 1.92231474565604 0.222968251105146 no 835 0.0272830828370132 254 2165101
SGTC_1367 1812-0510 76.9 µM 1.9212829529279 0.223112027526743 no 836 0.027348022544269 254 1142582 YDR527W RBA50
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.91858085609595 0.223488804555648 no 837 0.0275187001414002 266 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2013 4024628 200 µM 1.91637282915343 0.223796957635834 no 838 0.027658828366793 260 5230760
SGTC_656 4090-1979 187 µM 1.91177007212348 0.224440096003483 no 839 0.0279528460217101 271 22330961
SGTC_3214 9129694 49.47 µM 1.91044006095333 0.224626132204612 no 840 0.0280382884669684 245 17158655
SGTC_2911 7942208 15.64 µM 1.91005227200847 0.224680390908064 no 841 0.0280632416779407 219 1243384
SGTC_3259 9138485 49.47 µM 1.90934806149216 0.224778941729585 no 842 0.0281086030768161 267 17646153
SGTC_382 3229-0966 23.2 µM 1.90596479036975 0.225252755612525 no 843 0.0283273869832306 250 5722370
SGTC_833 3852-0053 558 µM 1.9059004444525 0.225261772484544 no 844 0.0283315616952656 264 3123681
SGTC_265 mycophenolic acid 32.932 µM 1.90514068070149 0.225368254563175 no 845 0.0283808932905569 268 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_486 niguldipine 82 µM 1.9002120228828 0.226059705378357 no 846 0.0287026505637141 207 1236 A calcium channel blocker.
SGTC_996 3970-0799 1.8 µM 1.89218309038094 0.227188663246296 no 847 0.0292332952788276 395 6615648 YGL040C HEM2
SGTC_793 0488-0545 106 µM 1.8916065988992 0.22726984650358 no 848 0.0292717080126549 245 292548
SGTC_2940 9060638 45.86 µM 1.89033631508428 0.227448789359848 no 849 0.0293564974304786 275 4027022
SGTC_1695 st026914 34.495 µM 1.88862705241194 0.227689695655534 no 850 0.0294709097354156 248 3289191
SGTC_2896 9052656 71.43 µM 1.88833406558986 0.227731004116451 no 851 0.0294905584063142 437 6469436
SGTC_2749 bexarotene 57.39 µM 1.88231924869993 0.22857996990148 no 852 0.0298963412712276 294 82146 An retinoic acid receptor inhibitor.
SGTC_2811 7967822 32.47 µM 1.88033595915739 0.228860291985557 no 853 0.0300311527348496 253 2232244
SGTC_2726 cimetidine 79.27 µM 1.88000317200688 0.228907347679626 no 854 0.0300538228099841 169 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_979 1426-2828 121 µM 1.87431449067136 0.229712559421366 no 855 0.0304435457123038 299 747872
SGTC_1887 st057648 70.8 µM 1.87398815480167 0.229758799113734 no 856 0.0304660288819553 237 688672
SGTC_2228 7354201 200 µM 1.8697207019878 0.230363949225146 no 857 0.0307613065802405 195 753451
SGTC_2043 5101342 149 µM 1.86829231585743 0.230566701738155 no 858 0.0308606685576368 270 678451
SGTC_2431 5490079 200 µM 1.86485424441323 0.231055128030907 no 859 0.0311009187267267 265 5722345
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.86237094487555 0.231408274474669 no 860 0.0312754108434782 263 75037 A free radical scavenger.
SGTC_3102 9121669 49.47 µM 1.86063086042509 0.231655908609905 no 861 0.0313981618416391 196 41905072
SGTC_1936 st074407 74.3 µM 1.85990617405122 0.231759083401726 no 862 0.0314494008444672 323 809813
SGTC_983 1491-0821 12.2 µM 1.85619383606018 0.232288016364394 no 863 0.0317129671862428 222 46495113
SGTC_874 0599-0792 117 µM 1.8556838696356 0.232360728682055 no 864 0.0317493156474325 305 765305
SGTC_2531 methyl deoxycholate 70.07 µM 1.85383643285786 0.232624246931861 no 865 0.0318812822178733 248 16667744 Haematoxylin.
SGTC_1657 st012939 43.4 µM 1.85183931333071 0.232909302690261 no 866 0.032024450246257 216 24207257
SGTC_2883 9059145 45.46 µM 1.85140280837766 0.232971632377433 no 867 0.0320558126841686 212 16476510
SGTC_1513 0337-0559 19 µM 1.84536074073304 0.23383534604648 no 868 0.0324925400431607 253 775073
SGTC_649 1123-0311 367 µM 1.84223182080779 0.234283321663373 no 869 0.0327206238728209 338 693629 YIL048W NEO1
SGTC_1492 4158-0558 28.5 µM 1.84180812121428 0.234344020336171 no 870 0.0327516108614931 242 3967268
SGTC_149 3970-0822 46.1 µM 1.84071817509163 0.23450020463604 no 871 0.0328314345365192 439 3114250 YBL034C STU1
SGTC_1525 8-methoxypsoralen 92.5 µM 1.84038404197802 0.234548095914756 no 872 0.0328559373205172 303 4114 Related to psoralen; DNA damaging agent.
SGTC_986 1493-0483 84 µM 1.83996934786095 0.234607541520411 no 873 0.0328863687984433 235 40079
SGTC_2779 methotrexate 400 µM 1.83909232217056 0.2347332889109 no 874 0.0329508040573693 279 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2539 epi(13)torulosol 80 µM 1.83780917480444 0.234917332894581 no 875 0.0330452646058892 279 6708597
SGTC_1274 0865-0114 173 µM 1.82693305547114 0.236480511174391 no 876 0.0338549177288523 278 870624
SGTC_2012 4023501 200 µM 1.82391647833396 0.236915082854198 no 877 0.0340823500331409 266 3477460
SGTC_3037 9091026 49.47 µM 1.82209828217338 0.237177226252998 no 878 0.034220037171857 437 25236398 YIL048W NEO1
SGTC_1545 lovastatin 49.4 µM 1.82108842838208 0.237322893483872 no 879 0.0342967079945306 314 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3288 9119690 36.221 µM 1.81943879874443 0.237560951373689 no 880 0.0344222559746653 254 17595618 YKL019W RAM2
SGTC_2790 5423970 71.43 µM 1.81869220007471 0.237668736016807 no 881 0.0344792011893375 345 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2992 9074591 71.4286 µM 1.81770410864075 0.237811425628883 no 882 0.0345546847229265 245 17741321
SGTC_1705 st027868 56.3335 µM 1.81624555379473 0.238022140379826 no 883 0.0346663565321845 243 292948
SGTC_2441 5730946 39.09 µM 1.81031919763719 0.2388793619943 no 884 0.0351231508207687 290 1774275
SGTC_2667 digitoxin 100 µM 1.80358201405547 0.239855913466341 no 885 0.0356484288778595 167 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_658 3253-0951 102 µM 1.79601121709113 0.240955890278394 no 886 0.0362463665408856 385 1184878
SGTC_1105 epirubicin 18.1 µM 1.7933556872417 0.241342366685347 no 887 0.0364580341691124 276 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2273 7815444 169.05 µM 1.79279915418045 0.241423405203221 no 888 0.0365025224033589 275 2824616
SGTC_2306 7482397 179.52 µM 1.78976180123885 0.241865944017249 no 889 0.036746106223313 278 891448
SGTC_1352 1496-0991 99 µM 1.78961382672993 0.241887514969886 no 890 0.0367580070784169 298 3000039
SGTC_2319 6033012 152.6 µM 1.7875661280653 0.242186124938295 no 891 0.0369230171705196 238 847246
SGTC_2998 9066762 71.4286 µM 1.78426817180277 0.242667476162525 no 892 0.037190049748817 349 4945196
SGTC_1281 0884-0031 11.8 µM 1.78010743293015 0.243275492494504 no 893 0.0375291901912913 317 1548255
SGTC_2165 5727197 32.143 µM 1.77927832327002 0.243396750111049 no 894 0.0375970714908482 311 1361712
SGTC_2813 7971799 71.43 µM 1.7758297794997 0.243901451224189 no 895 0.0378804888729464 272 2234054
SGTC_361 000s-0510 1.45 µM 1.77575384726416 0.243912570405487 no 896 0.037886748899895 325 660
SGTC_531 3788-1495 174 µM 1.76845604560157 0.244982503554822 no 897 0.0384923470730204 295 2896655
SGTC_3122 9126309 49.47 µM 1.76700514905691 0.245195520496171 no 898 0.0386136829899124 246 17591206
SGTC_1714 st033236 13.627 µM 1.76685026167902 0.245218266549214 no 899 0.0386266543384882 302 2916566
SGTC_471 1-acyl-paf 4 µM 1.76116551444377 0.246053886988945 no 900 0.0391051965097329 306 16759367
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.75885761054297 0.246393569127389 no 901 0.0393008483142112 270 97141
SGTC_1660 st012960 28.1 µM 1.75839180873065 0.246462157284019 no 902 0.0393404329595557 330 24207266
SGTC_858 0438-0351 2.77 µM 1.75315088625447 0.24723457470256 no 903 0.0397880554155544 321 2799119
SGTC_990 3985-0011 41.3 µM 1.75314688086308 0.24723516551959 no 904 0.0397883990892143 259 5399565 YGL099W LSG1
SGTC_1249 0481-0015 10.2 µM 1.75312078774574 0.247239014414891 no 905 0.039790638009921 268 4227577
SGTC_2966 9084041 48.03 µM 1.75197363966001 0.247408257475452 no 906 0.0398891703606488 300 17741380
SGTC_2033 5192550 145 µM 1.74976163643826 0.247734777339436 no 907 0.040079726522512 276 182073
SGTC_706 4262-0057 46.9 µM 1.74890878203688 0.247860730952276 no 908 0.0401533941558472 323 883298
SGTC_1366 1683-0113 21.9 µM 1.74696059139582 0.248148577232936 no 909 0.0403220871232605 271 708623
SGTC_2443 5493264 126.67 µM 1.74606119919441 0.248281523074852 no 910 0.0404001590536037 296 5340055
SGTC_416 estradiol valerate 100 µM 1.74603348910511 0.248285619711927 no 911 0.0404025663815209 300 13791 A steroid.
SGTC_948 3448-0295 75.3 µM 1.74491038522263 0.248451688803809 no 912 0.0405002346662637 349 678569
SGTC_956 1185-0240 191 µM 1.7439344676734 0.248596042066312 no 913 0.0405852587752598 297 1416193
SGTC_3256 9138902 49.47 µM 1.74032532163154 0.249130278361629 no 914 0.0409009551007385 205 17228773
SGTC_1888 azatryptophan 97.5 µM 1.73833299586236 0.249425449608696 no 915 0.0410760777889957 257 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_553 k007-0256 45.7 µM 1.7378338908445 0.24949942317053 no 916 0.0411200435419977 324 6287000
SGTC_1940 st075990 51.1 µM 1.734423069127 0.250005261200183 no 917 0.0414215224050466 348 1084979
SGTC_263 alizarin 107.927 µM 1.73352823050348 0.25013805927664 no 918 0.0415009121457623 408 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1964 st076914 61 µM 1.73243935105571 0.250299704336582 no 919 0.0415976833596706 269 24208661
SGTC_2385 9074692 200 µM 1.73142837817831 0.250449833667641 no 920 0.0416876944138868 348 17046906
SGTC_1296 1068-0102 11.9 µM 1.72771363757594 0.25100188170431 no 921 0.0420197886613303 308 767053
SGTC_332 4112-0506 40.9 µM 1.72752815768604 0.251029462760141 no 922 0.0420364263571368 294 2790355
SGTC_626 0214-0009 33 µM 1.72731702140773 0.251060860899592 no 923 0.0420553719409982 311 3437874
SGTC_3174 9107204 49.47 µM 1.7239322884555 0.251564489059416 no 924 0.0423600337921331 325 3938802
SGTC_1787 fluconazole 80 µM 1.72275889111083 0.25173920812332 no 925 0.042466067824479 409 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1815 st051655 58.2 µM 1.72224887492826 0.251815169593255 no 926 0.0425122223090647 263 5984156
SGTC_1141 3253-0389 52.6 µM 1.72222899963557 0.251818130051044 no 927 0.0425140217668251 277 5402031
SGTC_1784 st039334 36.3 µM 1.72030402724109 0.252104944928481 no 928 0.0426885958978018 311 3496984
SGTC_320 4092-0846 5.34 µM 1.71996427543247 0.252155584772849 no 929 0.042719467789105 302 1359356
SGTC_827 3253-0474 693 µM 1.71913244108024 0.252279591929131 no 930 0.0427951294499313 337 5402065
SGTC_2172 5754775 163.918 µM 1.7162332427046 0.252712046186819 no 931 0.0430596805778255 319 2263357
SGTC_1733 st037357 54.9 µM 1.7067574371881 0.254128208005783 no 932 0.0439335732578983 361 1272339 YGL099W LSG1
SGTC_460 trequinsin 123 µM 1.70547130205931 0.254320741578234 no 933 0.0440532800619491 270 5537 A vasodilator.
SGTC_2971 9092186 9.93 µM 1.70222183602707 0.254807524919588 no 934 0.0443568954418614 292 25236400
SGTC_367 0335-0881 7.1 µM 1.70116144501764 0.254966481329739 no 935 0.0444563377175331 370 23828853
SGTC_286 k060-0067 22.9 µM 1.70007868568456 0.255128844354974 no 936 0.0445580629374473 320 5985051
SGTC_2957 9076800 11.52 µM 1.69961230849137 0.255198795679072 no 937 0.0446019368045793 314 16459615
SGTC_3191 9110352 49.47 µM 1.69748797890036 0.25551754801509 no 938 0.0448022209471057 274 17122424
SGTC_120 rhodamine 6G 52.259 µM 1.69304677573429 0.256184614966447 no 939 0.0452232820112515 415 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2519 cryptotanshinone 88.04 µM 1.69277549590761 0.256225390495497 no 940 0.0452491043064707 275 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3163 9099914 49.47 µM 1.69258771789734 0.256253617014811 no 941 0.0452669852658892 214 16268368
SGTC_892 0929-0076 29 µM 1.68821323953282 0.256911640757786 no 942 0.0456851513229393 401 5751038
SGTC_1250 0485-0349 40.2 µM 1.68708197837121 0.257081951836522 no 943 0.0457937949121503 354 6842794 YDL195W SEC31
SGTC_3208 9114115 49.47 µM 1.6869678102255 0.257099143083056 no 944 0.0458047708707042 349 650895
SGTC_3252 9135871 49.47 µM 1.6852962819007 0.257350907430766 no 945 0.0459657113647442 310 17682838
SGTC_3171 9103192 49.47 µM 1.68260607689796 0.257756372967812 no 946 0.0462256872589016 266 13018434
SGTC_1185 1319-0113 81.3 µM 1.68037497764384 0.25809289381784 no 947 0.0464421906761186 293 4672763
SGTC_2414 st077232 92.9 µM 1.67992607015386 0.25816063089094 no 948 0.0464858503735706 333 729801
SGTC_1411 3909-8223 150 µM 1.67963976511524 0.258203837178397 no 949 0.0465137129365442 337 X1411
SGTC_614 0462-0418 107 µM 1.67336118414046 0.259152279300934 no 950 0.0471281071690642 314 5188303
SGTC_613 3914-0030 117 µM 1.67312396720068 0.259188148555628 no 951 0.0471514471122502 101 1145395
SGTC_1227 3909-8010 46.6 µM 1.67280042322536 0.259237075342109 no 952 0.0471832957707592 329 15982272
SGTC_2117 5521686 200 µM 1.66647583258183 0.260194446823991 no 953 0.0478093389206995 328 803312
SGTC_632 0781-2353 4.65 µM 1.66583147156877 0.260292087786726 no 954 0.0478734929339605 368 6811515 YHR007C ERG11
SGTC_251 melphalan 456.522 µM 1.66536784795977 0.260362353024113 no 955 0.0479196949486399 386 460612 A DNA alkylator.
SGTC_2887 9044784 58.44 µM 1.6625245262853 0.260793490923552 no 956 0.0482038249421775 351 6465546
SGTC_876 0720-0963 56.8 µM 1.65675626984861 0.261669268901671 no 957 0.0487843807360979 356 765861
SGTC_2278 7948257 134.34 µM 1.65273949267271 0.262280014913567 no 958 0.0491919465893121 319 1247028
SGTC_1483 3453-0561 55.9 µM 1.65127766743739 0.262502464721019 no 959 0.0493409451344238 379 4546991
SGTC_2549 cedrol 20.94 µM 1.65100822697327 0.262543476726691 no 960 0.0493684475106614 281 6708665 A sedative which affects the nervous system.
SGTC_442 cape 100 µM 1.65090819660507 0.262558703359234 no 961 0.0493786609433163 299 5281787
SGTC_68 0986-0284 82.829 µM 1.64992625235889 0.262708199000922 no 962 0.0494790102894715 369 423278 YIL048W NEO1
SGTC_737 1950-0117 57.9 µM 1.64977852963558 0.262730692745373 no 963 0.0494941208222811 347 5393513
SGTC_2448 5185112 27.17 µM 1.64921152562824 0.262817039613475 no 964 0.0495521537714335 319 5718189
SGTC_578 3460-0051 92 µM 1.64815636690933 0.262977764317207 no 965 0.049660293983849 388 2876744
SGTC_1677 st019204 53.9 µM 1.64760222945363 0.263062192189206 no 966 0.0497171613228337 333 3945625
SGTC_358 0075-0058 9.45 µM 1.64429180242208 0.26356685419381 no 967 0.0500579709114562 461 1069125
SGTC_1661 st013063 9.66 µM 1.64424144566952 0.263574534701969 no 968 0.05006316950348 375 721395
SGTC_564 3555-0129 330 µM 1.6407830051052 0.264102295786341 no 969 0.0504212336570169 255 563260
SGTC_1564 D-Arginine 115 µM 1.64000368759596 0.26422129460915 no 970 0.0505022001087475 361 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2025 5147754 141 µM 1.637398146593 0.264619348989095 no 971 0.0507736526187589 315 315777 YLR208W SEC13
SGTC_913 3487-1245 167 µM 1.63538079439081 0.264927753820979 no 972 0.0509846229769895 364 4016153
SGTC_3322 9139058 2.11 µM 1.63048308034318 0.265677256291513 no 973 0.0514997191519441 352 4908926 YPR165W RHO1
SGTC_739 1486-1183 203 µM 1.63047625748396 0.26567830115047 no 974 0.0515004395928511 352 4346692
SGTC_942 3253-1115 227 µM 1.63023513801204 0.265715227746773 no 975 0.051525905081902 350 46497897
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.62435634633516 0.266616348335857 no 976 0.0521498890316318 345 521171
SGTC_1370 2001-0092 44.6 µM 1.61970583604519 0.267330286900102 no 977 0.0526477409790467 427 790957
SGTC_1507 4075-3230 155 µM 1.61958376135577 0.267349040585794 no 978 0.0526608600884008 292 659771
SGTC_165 k038-0023 64.381 µM 1.61866684513291 0.267489922763153 no 979 0.0527594820782824 446 46368543
SGTC_2643 anethole 100 µM 1.61760243700696 0.267653513690891 no 980 0.0528741517824567 382 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1018 4259-0013 28.1 µM 1.61353693645 0.268278812050189 no 981 0.0533139526373408 342 6801262
SGTC_599 1935-0052 86.5 µM 1.61175592696354 0.268552973290092 no 982 0.0535075311211373 382 9557311
SGTC_2639 lactacystin 53 µM 1.61103093525052 0.26866461583526 no 983 0.0535864900106672 390 3870 A proteasome inhibitor.
SGTC_3331 9141060 1.957 µM 1.61093574585867 0.268679275922163 no 984 0.0535968639446387 342 4906567 YPR165W RHO1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.60963195265788 0.268880113129757 no 985 0.0537391141737449 389 16486 A toxic proline analog.
SGTC_762 1165-0429 115 µM 1.60522534832048 0.26955946699352 no 986 0.0542221104748089 374 5967793
SGTC_1719 st032227 49.2 µM 1.60474627851358 0.269633375649054 no 987 0.054274826425145 369 3125804
SGTC_2787 5284540 71.43 µM 1.60308123352855 0.269890329957452 no 988 0.0544583603267202 369 736958
SGTC_101 0490-5701 117.494 µM 1.60015648119781 0.27034198232417 no 989 0.0547819368472135 311 4661669
SGTC_1313 1220-0047 237 µM 1.59673062076729 0.270871497911629 no 990 0.0551628834724733 433 3528706
SGTC_887 0885-0007 9.62 µM 1.59614421368726 0.270962187344312 no 991 0.0552282996440445 406 5719458
SGTC_949 1165-0505 146 µM 1.59583167564039 0.271010528382023 no 992 0.0552631895976373 416 6244267
SGTC_1032 k061-1018 98.7 µM 1.59330264254314 0.271401858416598 no 993 0.0555461570832339 440 4005393
SGTC_1088 bifonazole 369 nM 1.59297357223685 0.271452797815639 no 994 0.0555830599184787 345 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2114 5491910 81.25 µM 1.59190173753182 0.271618748613476 no 995 0.0557033925496662 359 2849228
SGTC_1489 4065-0444 182 µM 1.59030564622978 0.271865962972112 no 996 0.0558829632732131 346 2877968
SGTC_2715 st079500 56.4 µM 1.58737618515992 0.272319990535121 no 997 0.0562137348490985 334 28246688
SGTC_2088 5278280 127.392 µM 1.58648079739679 0.272458838877219 no 998 0.0563151423821298 423 791502
SGTC_3229 9132204 49.47 µM 1.58496614919005 0.272693796334485 no 999 0.0564870127691478 292 17682924
SGTC_3305 9127027 53.8275 µM 1.58313441695736 0.272978075219455 no 1000 0.056695415289055 371 41905295
SGTC_888 0916-0002 6.97 µM 1.58109339398926 0.273295008324387 no 1001 0.0569283424845025 360 2802138 YIL048W NEO1
SGTC_1669 st015249 58.4 µM 1.57789771547351 0.273791603870949 no 1002 0.0572945549645078 331 722793
SGTC_534 k292-0788 63.4 µM 1.57629242640226 0.274041227587558 no 1003 0.0574792131224959 421 4146317
SGTC_3066 9117245 49.47 µM 1.57551740912994 0.274161783626193 no 1004 0.0575685316253266 381 17176980
SGTC_511 blebbistatin 171 µM 1.5713149756646 0.27481593933841 no 1005 0.0580547521757379 376 3476986 A myosin inhibitor.
SGTC_3026 9090633 49.47 µM 1.56941270925499 0.275112301106258 no 1006 0.058275902283242 372 25236842
SGTC_229 benomyl 22.8748 µM 1.56930992754713 0.275128318364429 no 1007 0.0582878701033698 417 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_580 1123-0028 41 µM 1.56768129496034 0.275382181886273 no 1008 0.0584777645597004 451 1677248 YPR107C YTH1
SGTC_808 0711-0032 135 µM 1.56677216874911 0.275523942277636 no 1009 0.0585839774663752 371 4252555
SGTC_1443 4112-3303 14 µM 1.56635525516179 0.275588963771382 no 1010 0.0586327359653994 393 704433
SGTC_1826 st055655 41.6 µM 1.56548475146645 0.275724751118409 no 1011 0.0587346450194434 400 676168
SGTC_1361 1608-0041 5.61 µM 1.56299845048791 0.276112762998005 no 1012 0.0590264796419353 395 X1361
SGTC_661 1304-0007 33.6 µM 1.56071818499631 0.276468856492326 no 1013 0.0592951293243828 364 3117130
SGTC_306 1672-3436 11.6 µM 1.55940947710297 0.276673330129539 no 1014 0.0594497473275139 383 6797378
SGTC_1448 4255-0083 152 µM 1.55865154239826 0.276791784371802 no 1015 0.0595394383496387 385 5399660
SGTC_1638 st008370 60.6 µM 1.55808541031302 0.27688027884119 no 1016 0.0596065013679369 418 24207134
SGTC_2543 pimpinellin 60.67 µM 1.55640114756375 0.277143634878867 no 1017 0.0598063662462605 375 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.55590968604096 0.277220504271603 no 1018 0.0598647849023108 400 115019
SGTC_1256 0570-0116 285 µM 1.54761826928088 0.278518932943197 no 1019 0.0608571150996477 363 410638
SGTC_3294 9122953 26.2835 µM 1.54642209552205 0.278706496956592 no 1020 0.0610013306466709 394 16459826
SGTC_1615 st002656 86.5 µM 1.54625258489767 0.2787330817586 no 1021 0.0610217891271359 373 1584458
SGTC_1379 2144-0755 36.5 µM 1.54617031283617 0.278745985149742 no 1022 0.0610317205933629 430 5392327
SGTC_912 3474-0017 2.18 µM 1.5450307741517 0.278924738094128 no 1023 0.0611694099100379 403 3360550
SGTC_458 nppb 133 µM 1.54482079005669 0.278957683187299 no 1024 0.0611948085447992 344 4549 A chloride channel blocker.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.5446100484438 0.27899074903298 no 1025 0.0612203070901571 498 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2950 9072895 21.46 µM 1.54186859197695 0.279421063497597 no 1026 0.0615527648171382 450 17332245
SGTC_2052 5265182 7.135 µM 1.54142905672887 0.27949008540338 no 1027 0.0616061983680765 414 1239884
SGTC_2413 inermin 26.06 µM 1.54045861256539 0.279642507286001 no 1028 0.0617243018773457 448 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3005 9076496 71.4286 µM 1.53955323822215 0.279784745408432 no 1029 0.0618346456706557 355 21368410
SGTC_3078 9116413 49.47 µM 1.53869872176192 0.279919025732239 no 1030 0.061938932271122 366 17177322
SGTC_1308 1187-1617 41.4 µM 1.53266371122358 0.28086826737283 no 1031 0.062679367387499 454 2882570
SGTC_891 0929-0073 133 µM 1.53187920166246 0.280991776410021 no 1032 0.0627761233882131 375 5603632
SGTC_3227 9130768 49.47 µM 1.52990630062409 0.281302495460062 no 1033 0.0630199617913773 344 17720899
SGTC_1530 rhein 70.4 µM 1.52678425096515 0.281794536581479 no 1034 0.0634073345288322 422 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.525872818251 0.281938258340427 no 1035 0.0635207706520681 480 65057 A dermal irritant. YDR527W RBA50
SGTC_417 st075190 100 µM 1.52075125185561 0.282746522581282 no 1036 0.0641611359168452 417 222757
SGTC_1986 st071812 45 µM 1.51710180786731 0.283323141047903 no 1037 0.0646204909453285 362 11838594
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.51493862738381 0.283665193281995 no 1038 0.0648939735271339 347 6857784
SGTC_3202 9113761 49.47 µM 1.51267150208598 0.284023893906587 no 1039 0.0651815609161093 500 4798415
SGTC_2328 6201408 200 µM 1.51168806863351 0.284179558491834 no 1040 0.0653066176666468 402 2890418
SGTC_2661 dactinomycin 12.96 µM 1.51014469520754 0.284423936429777 no 1041 0.0655032534640529 447 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3167 9103034 49.47 µM 1.50876688873492 0.284642183267558 no 1042 0.0656791825819859 314 5127859
SGTC_168 3970-0862 530.542 µM 1.50645989733873 0.285007793458127 no 1043 0.0659745772164698 635 3135186
SGTC_1992 st073643 23.3 µM 1.50643270928156 0.285012103534898 no 1044 0.0659780645905377 395 3161292
SGTC_2237 6667747 47.222 µM 1.50339362147659 0.285494080788704 no 1045 0.0663687852274702 377 729940 YDL015C TSC13
SGTC_2078 5212016 200 µM 1.50218207642254 0.285686331154228 no 1046 0.0665250462159626 351 1899708
SGTC_2907 7721985 69.9 µM 1.49972022026864 0.286077172983295 no 1047 0.0668434452712276 423 3267881
SGTC_1984 st072354 53.1 µM 1.49828755274617 0.286304738733614 no 1048 0.0670292783107174 392 5762938
SGTC_563 tetrahydrosecaminediol 614 µM 1.49794576622006 0.286359041000818 no 1049 0.0670736708339533 442 334274 A psychoactive constituent of the cannabis plant.
SGTC_674 0498-0004 451 µM 1.49530817492242 0.286778259869969 no 1050 0.0674170162808262 429 4231473
SGTC_1879 gemcitabine 100 µM 1.49529670649043 0.28678008329805 no 1051 0.0674185121313965 411 60750 A nucleoside analog which inhibits DNA replication.
SGTC_455 paf C-16 10 µM 1.49415384278544 0.286961820940786 no 1052 0.0675677068253916 396 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1215 3852-0577 11.2 µM 1.48974609272164 0.287663249750645 no 1053 0.0681455050727235 470 2884876
SGTC_1236 0330-0013 258 µM 1.48924258892271 0.287743426537272 no 1054 0.0682117498111132 389 4617066
SGTC_82 0054-0107 293.755 µM 1.47399885091223 0.290175788003907 no 1055 0.0702409502769911 398 3104697
SGTC_1929 genistein trimethyl ether 50.5 µM 1.46423468229683 0.291738848527637 no 1056 0.0715649184948469 424 136420
SGTC_1724 st037281 8.293 µM 1.46404685920793 0.291768953912314 no 1057 0.0715905727095371 473 574124 YDL195W SEC31
SGTC_734 2023-0417 80 µM 1.46399160719697 0.291777810303759 no 1058 0.0715981207655358 456 3935732
SGTC_841 0251-0215 91.2 µM 1.46316767780885 0.291909893499127 no 1059 0.0717107513890877 527 3888614
SGTC_1272 0839-0021 27 µM 1.46108631171905 0.29224367892469 no 1060 0.0719958781135917 457 5027250
SGTC_3035 9091303 49.47 µM 1.45932905241268 0.292525626006594 no 1061 0.0722372814276634 389 25237002
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.45739143364133 0.292836657694152 no 1062 0.0725041801860805 537 368090
SGTC_323 4013-0906 34.3 µM 1.45390229566761 0.293397130144519 no 1063 0.0729866981364032 417 2910086
SGTC_2280 7785178 200 µM 1.45321811149962 0.293507091300119 no 1064 0.07308160252876 402 2954328
SGTC_1350 1495-0454 146 µM 1.45085232758936 0.293887463920158 no 1065 0.0734104925112118 518 1069057
SGTC_49 0717-0965 32.132 µM 1.44926973419579 0.294142041749433 no 1066 0.0736311349029455 464 5889349 YGL099W LSG1
SGTC_573 3702-0553 84.7 µM 1.44369774378963 0.295039168626505 no 1067 0.074412008187791 446 1222756
SGTC_1217 1183-1422 255 µM 1.44241919157057 0.295245201542134 no 1068 0.0745920765030045 458 2849664
SGTC_260 nsc-65238 3.989 µM 1.4393562216428 0.295739054481939 no 1069 0.0750248106173797 436 3246252
SGTC_1010 4112-3296 15.2 µM 1.43897676220836 0.295800262417305 no 1070 0.0750785533836258 488 704384
SGTC_641 4092-0595 30 µM 1.43816091740622 0.295931880312976 no 1071 0.0751942007350125 480 786260
SGTC_2670 beta-carotene 100 µM 1.43567553307828 0.296333005863058 no 1072 0.0755473452392177 358 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_503 tyrphostin 8 294 µM 1.43513753893016 0.296419867579504 no 1073 0.0756239541348352 462 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_731 3966-0296 387 µM 1.42785296688568 0.297597143467073 no 1074 0.0766670917929717 453 660956
SGTC_1270 0831-1170 17.3 µM 1.42570321614113 0.297944976866941 no 1075 0.0769770138964035 504 6764716
SGTC_317 4495-0002 170 µM 1.42500487953886 0.298058008807996 no 1076 0.0770778953026799 413 15991618
SGTC_3036 9090181 49.47 µM 1.42449375013237 0.298140751995248 no 1077 0.0771517964957899 423 25236586
SGTC_2008 4012253 172 µM 1.42328117266746 0.298337089578435 no 1078 0.0773273312912057 484 603940
SGTC_867 0518-0118 155 µM 1.42027456894533 0.2988241652244 no 1079 0.077763880927774 470 6848158
SGTC_1910 st062352 60.4 µM 1.41688340493274 0.299373973605514 no 1080 0.0782585095826078 471 2245730
SGTC_1257 0669-0121 16 µM 1.41577291363886 0.299554116879111 no 1081 0.0784210012291543 535 4307855
SGTC_166 k072-0058 166.424 µM 1.40498576777302 0.301306551847629 no 1082 0.0800127552214157 479 5846229
SGTC_1465 k213-0056 144 µM 1.40170279113648 0.301840805467229 no 1083 0.0805020084081491 464 24048857 YMR208W ERG12
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.40096803705943 0.301960433596188 no 1084 0.080611815692761 356 1241132 A phosphatase inhibitor.
SGTC_206 4546-0025 72.014 µM 1.39860855002578 0.302344734658381 no 1085 0.08096520050108 556 6620745 YIL048W NEO1
SGTC_1344 1488-0097 29.1 µM 1.39809330743438 0.302428683887852 no 1086 0.081042524676789 476 747966
SGTC_3077 9117319 49.47 µM 1.39697107781488 0.302611566568822 no 1087 0.0812111342996782 411 17154678
SGTC_3085 9117376 49.47 µM 1.38994581182484 0.303757554213597 no 1088 0.0822726664215324 479 16480349
SGTC_2303 7774051 200 µM 1.38649064794789 0.304321882955836 no 1089 0.0827985669933921 459 2953184
SGTC_2110 5483698 200 µM 1.38325390529354 0.30485096024777 no 1090 0.0832935131616566 474 2848765 YHR062C RPP1
SGTC_162 k030-0015 37.8 µM 1.38015557514512 0.305357795216079 no 1091 0.0837693744588864 482 1809920 YMR134W ERG29
SGTC_1911 st060208 74.3 µM 1.37504784700563 0.306194148879598 no 1092 0.0845583057225717 532 688783
SGTC_2947 9072639 7.68 µM 1.37365744413196 0.306421992583866 no 1093 0.0847740271230383 541 16488146
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.37331143733538 0.306478703951805 no 1094 0.084827774245764 480 6708760
SGTC_2979 9012552 45.46 µM 1.37281576148189 0.306559954523473 no 1095 0.0849048147909219 436 17100905
SGTC_2908 7930301 100 µM 1.36826652416854 0.307306103577424 no 1096 0.0856143325925016 531 2223178
SGTC_1923 st058458 19.1 µM 1.36311183223991 0.308152521856422 no 1097 0.0864236341425866 555 3534982
SGTC_2801 7907800 81.82 µM 1.35822513088389 0.308955878409778 no 1098 0.0871961293008376 536 6620925
SGTC_352 k048-0007 5.11 µM 1.35744444372591 0.309084305475432 no 1099 0.0873200173510604 563 6811911
SGTC_3088 9117578 49.47 µM 1.3571768940981 0.309128324139818 no 1100 0.0873625052972655 481 678341
SGTC_2881 9058953 51.95 µM 1.35540691445487 0.309419599458753 no 1101 0.0876439739366758 531 17122249
SGTC_1120 ficusin 1.78878 µM 1.354342293839 0.30959485562325 no 1102 0.0878135993738122 517 6199 A DNA cross-linker.
SGTC_1680 diphenhydramine 100 µM 1.35340817035439 0.309748665225145 no 1103 0.0879626343570224 498 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_427 1354-0053 47.3 µM 1.34850904967481 0.310555882873045 no 1104 0.0887473557361968 508 6813657
SGTC_1642 st009582 77.7 µM 1.3463493223043 0.310912026760861 no 1105 0.0890949431538745 475 6739311
SGTC_1233 0325-0408 14.2 µM 1.34510820782967 0.311116769515135 no 1106 0.0892951465016896 510 12874
SGTC_588 3970-1144 52.9 µM 1.34475356764131 0.311175284134937 no 1107 0.0893524147103003 549 1888707
SGTC_3051 9093778 49.47 µM 1.34291006675287 0.311479533383329 no 1108 0.0896505481898159 425 17217378
SGTC_1479 0549-0158 134 µM 1.34118911237895 0.311763673935122 no 1109 0.0899295301998869 571 5440202
SGTC_1294 1000-1494 117 µM 1.34113187075582 0.311773126819548 no 1110 0.0899388206503978 509 712797 YDL207W GLE1
SGTC_236 1509-0011 5.31 µM 1.34046139454065 0.31188385852634 no 1111 0.090047693632997 821 3107280
SGTC_3120 9124077 49.47 µM 1.3390493992476 0.312117110548339 no 1112 0.0902772958580957 517 18774327 YGL155W CDC43
SGTC_54 0159-0055 9 µM 1.33715697655679 0.312429844057442 no 1113 0.0905857011029478 516 3319099
SGTC_528 3492-0019 172 µM 1.33651801281751 0.312535466944815 no 1114 0.0906900084648381 755 2869262
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.33225769653856 0.313240105098595 no 1115 0.0913877615291843 607 551469
SGTC_1384 3089-0840 101 µM 1.33214684955044 0.313258447837524 no 1116 0.091405968977964 472 1069836
SGTC_3250 9135583 49.47 µM 1.33193624161416 0.313293300092368 no 1117 0.0914405703180385 493 7699353
SGTC_2250 alverine citrate 130 µM 1.33154139675194 0.31335864511403 no 1118 0.0915054665955281 659 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_451 chloral hydrate 100 µM 1.33125050361018 0.313406790349413 no 1119 0.091553299312973 609 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_592 k241-0073 46.5 µM 1.32983276263517 0.313641483778154 no 1120 0.0917866893502459 549 4230158
SGTC_1788 fluconazole 20 µM 1.32950722417409 0.313695384204298 no 1121 0.0918403420043825 512 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.3276326623342 0.314005838659374 no 1122 0.0921497444236899 345 6708630 An antioxidant.
SGTC_1163 k060-0048 49.9 µM 1.32612068771118 0.314256339403065 no 1123 0.0923998623362145 567 6809982
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.3260785260451 0.314263325885261 no 1124 0.0924068441085774 418 279621
SGTC_519 k048-0011 62.8 µM 1.32527496403877 0.314396494433087 no 1125 0.0925399848032135 526 6836379
SGTC_2288 7946289 167.31 µM 1.32192669990589 0.314951638025916 no 1126 0.0930962802643713 587 1246052
SGTC_854 0422-0053 192 µM 1.32186900301075 0.314961207865097 no 1127 0.09310588789715 509 3596728
SGTC_1534 6-azauridine 81.6 µM 1.31901521821882 0.315434703016882 no 1128 0.093582012421024 594 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2041 5107442 45.335 µM 1.31496618838425 0.316107031450634 no 1129 0.0942606330808116 538 793005
SGTC_2111 5486399 200 µM 1.31372911723185 0.316312564624914 no 1130 0.0944686893416312 595 689674
SGTC_214 4373-3496 70 µM 1.31360534566587 0.316333131775052 no 1131 0.0944895244262569 711 3779166
SGTC_3274 9138298 49.47 µM 1.3130002201523 0.316433693801667 no 1132 0.0945914369948452 561 17015756
SGTC_1388 3346-4487 254 µM 1.3107844192849 0.316802039706884 no 1133 0.09496530397555 590 3345614
SGTC_2248 tofa 1.1 µM 1.30739564611576 0.317365727191999 no 1134 0.0955391876335195 503 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2372 9071633 200 µM 1.3054192208049 0.317694680952358 no 1135 0.0958750684835779 585 21321366
SGTC_796 1234-0020 70.7 µM 1.30314639192302 0.318073145722419 no 1136 0.0962623939493066 553 46495034
SGTC_3147 9097027 49.47 µM 1.29997038565263 0.318602323224915 no 1137 0.0968055596523141 570 25236841
SGTC_307 1501-1223 22.3 µM 1.2992946709069 0.31871495676779 no 1138 0.0969214112612445 548 2830329
SGTC_725 1497-0963 19 µM 1.29883221433998 0.318792052385502 no 1139 0.0970007583059207 564 3549977
SGTC_2780 5215298 71.43 µM 1.29817422087846 0.318901759257995 no 1140 0.0971137372166382 581 2834131
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.29702900440424 0.31909273838501 no 1141 0.097310603648941 513 616764
SGTC_1432 4049-0298 68.4 µM 1.29518645354178 0.319400107499475 no 1142 0.0976279583785976 527 741646
SGTC_355 1311-2252 105 µM 1.29385653460916 0.319622037962017 no 1143 0.0978574902363778 560 5338538
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.29286911464816 0.319786855645214 no 1144 0.0980281655903748 566 5282309
SGTC_863 0466-0191 129 µM 1.2805909420729 0.32183926167906 no 1145 0.100168691606807 615 765160 YPR165W RHO1
SGTC_870 0573-2213 57.6 µM 1.27671019413396 0.322489099347009 no 1146 0.100852290552791 539 3916321
SGTC_750 4073-0104 132 µM 1.26574323994404 0.324328462778063 no 1147 0.102802511080884 465 22330957
SGTC_1853 st056710 91.2 µM 1.26467348058055 0.324508112053671 no 1148 0.102994200107556 590 269167
SGTC_3254 9136651 49.47 µM 1.25995044311155 0.325301759770438 no 1149 0.103843620033991 601 16454030
SGTC_1062 mesoridazine 14.2 µM 1.25802457640571 0.325625605539393 no 1150 0.104191434141956 592 4078 A neuroleptic.
SGTC_2381 9035592 200 µM 1.25500909046544 0.3261329415681 no 1151 0.104737729992681 500 4749657
SGTC_1124 fisetin 1.16336 µM 1.25083262853707 0.326836135960051 no 1152 0.10549777395694 525 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2688 kanamycin b 96.69 µM 1.24487410658173 0.327840442307568 no 1153 0.10658901512396 1068 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2365 9042475 200 µM 1.2430638523386 0.328145807089636 no 1154 0.106922152421799 595 6464479
SGTC_1287 0971-0001 34.6 µM 1.24187508935559 0.328346397424753 no 1155 0.107141326182086 633 4665869
SGTC_1459 k035-0031 35.7 µM 1.24077522141264 0.328532031809229 no 1156 0.107344398634352 514 3877128 YMR208W ERG12
SGTC_1727 st034309 9.9045 µM 1.23951748398162 0.328744363094518 no 1157 0.107576958972505 682 870305
SGTC_1613 st002381 52.1 µM 1.23883029391269 0.32886039791402 no 1158 0.107704176245144 570 551167
SGTC_2190 6049624 200 µM 1.23298482275402 0.329848095394009 no 1159 0.108790713351049 524 2265554
SGTC_1415 3966-0071 78.1 µM 1.23122186210214 0.33014621271131 no 1160 0.109119948447343 579 2893185
SGTC_2963 9082507 9 µM 1.23059110465836 0.330252900246924 no 1161 0.109237916928372 562 16459611
SGTC_426 0988-0037 14.6 µM 1.22659224656773 0.330929595658717 no 1162 0.109987942405557 658 5383008
SGTC_775 4577-0580 57.3 µM 1.21838532529161 0.332320118075439 no 1163 0.11153878950117 620 2006902
SGTC_1892 st058411 7.36 µM 1.21791237992269 0.332400321192203 no 1164 0.111628635586241 681 3934738
SGTC_1277 0873-0036 22 µM 1.21326529665237 0.333188791499228 no 1165 0.112514203219389 664 5965735
SGTC_606 k015-0008 38.6 µM 1.21221848910664 0.333366505212597 no 1166 0.112714377905907 659 1970475
SGTC_2624 nerol 100 µM 1.20840273483861 0.334014612063423 no 1167 0.113446194183382 591 637566 A natural product oil.
SGTC_1959 st077091 55.8 µM 1.20835362388535 0.334022956804275 no 1168 0.113455635114827 630 821356 YKL052C ASK1
SGTC_1512 0259-0544 12.2 µM 1.20653960730239 0.334331244863816 no 1169 0.113804748458732 661 18476
SGTC_2200 6600604 21.907 µM 1.19934563483182 0.335554943274483 no 1170 0.115196788705778 659 2904777
SGTC_693 4161-2696 114 µM 1.19904436065937 0.335606228351203 no 1171 0.115255348471515 567 805759
SGTC_2537 larixol 68.93 µM 1.19861473307297 0.335679367975276 no 1172 0.115338893360848 677 6708759
SGTC_85 0868-0259 160.055 µM 1.19854888787694 0.335690577984684 no 1173 0.11535170134529 583 83173
SGTC_2933 9026794 32.47 µM 1.196475499081 0.336043642920133 no 1174 0.115755527092018 637 17586027
SGTC_2080 5212524 12.4 µM 1.19611615053093 0.33610484895003 no 1175 0.115825617953951 601 260183
SGTC_1737 st035557 69.7 µM 1.19534612567375 0.336236018039276 no 1176 0.115975912618353 521 5716916
SGTC_2835 9006588 71.43 µM 1.19008007531131 0.337133591689889 no 1177 0.117007460332736 616 2345538
SGTC_44 0929-0055 61.211 µM 1.18775446276041 0.337530277176451 no 1178 0.117465079886259 587 1379590
SGTC_2842 9000675 19.48 µM 1.1852838687729 0.337951890362398 no 1179 0.117952614644394 580 2989072
SGTC_33 0986-0033 35.816 µM 1.18504626293257 0.337992449135093 no 1180 0.11799957794783 590 2848082
SGTC_2150 5556613 200 µM 1.18124077151755 0.338642293801565 no 1181 0.118753544365896 666 743190
SGTC_2567 aureobasidin a 60 nM 1.17953304988582 0.338934069226233 no 1182 0.119092992195578 639 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3007 9078383 71.4286 µM 1.17894335229964 0.339034845379856 no 1183 0.11921036672692 648 6496995
SGTC_152 4469-0003 551.229 µM 1.17169325283046 0.340274787950489 no 1184 0.120660116446789 635 697280
SGTC_541 4513-1321 94 µM 1.17015590142424 0.340537934905533 no 1185 0.120969117804051 629 747515
SGTC_1116 jasmonic acid 1.58368 µM 1.16887061597613 0.340757995573791 no 1186 0.121227881939344 652 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3289 9119912 71.43 µM 1.16865758556045 0.340794474901298 no 1187 0.121270808538384 634 17014829
SGTC_2026 5148700 152 µM 1.16771675065273 0.34095560127068 no 1188 0.121460518906566 636 79838
SGTC_3057 9095946 49.47 µM 1.16628436826277 0.341200965234053 no 1189 0.121749745571611 644 24540043
SGTC_2049 5262831 67.185 µM 1.16619197511806 0.34121679428391 no 1190 0.121768418196 652 763417
SGTC_235 0330-0087 5 mM 1.1641241458593 0.341571133586531 no 1191 0.122186852352871 671 46494818 YHR062C RPP1
SGTC_1360 1598-0022 39.8 µM 1.16052403830195 0.342188374312835 no 1192 0.122917756269322 740 761525
SGTC_1518 st038567 90.8 µM 1.14669091400744 0.344563984690506 no 1193 0.125754693490593 635 77966
SGTC_930 2810-3379 265 µM 1.14307525627921 0.345185930715764 no 1194 0.126503673324381 749 1015764
SGTC_1607 st000305 50.6 µM 1.14282934695796 0.345228245929962 no 1195 0.126554725815489 676 5457690
SGTC_1804 st050076 49.1 µM 1.13887000912561 0.345909820971052 no 1196 0.127378688090431 681 3895976
SGTC_52 0329-0193 875 nM 1.13840416950442 0.345990045214634 no 1197 0.12747587690936 664 3739292
SGTC_2142 5622915 118.518 µM 1.13603067276832 0.346398902572549 no 1198 0.127971863735918 633 5322196
SGTC_2391 6285546 200 µM 1.13539702241254 0.346508085164103 no 1199 0.128104503354108 696 846083
SGTC_1195 1502-0147 41.1 µM 1.13282375477701 0.346951608976859 no 1200 0.128644136841892 696 817940
SGTC_1440 4100-1550 40 µM 1.13025079649073 0.347395289219974 no 1201 0.129185280530157 656 742806
SGTC_993 3909-8757 62.7 µM 1.12957807848084 0.347511327054854 no 1202 0.129327026199562 622 4288324 YLR208W SEC13
SGTC_954 1189-0853 2.85 µM 1.12950565896271 0.347523819625669 no 1203 0.129342291844896 698 2828194
SGTC_396 dithiazanine 1.25 µM 1.12234800979785 0.348759349354973 no 1204 0.130857250303024 643 10578 An antihelmenthic.
SGTC_2243 6634756 200 µM 1.12216856089778 0.348790345916435 no 1205 0.130895388644944 643 885676
SGTC_2281 7943571 200 µM 1.11935825009495 0.349275907981855 no 1206 0.131493667290401 738 1244024
SGTC_406 estrone 100 µM 1.11855451853579 0.349414821158787 no 1207 0.131665117878726 698 5870 A steroid.
SGTC_2390 9097792 176.6 µM 1.11680540154674 0.349717199994568 no 1208 0.132038769404542 649 4497149
SGTC_790 1575-0012 79.1 µM 1.11531016188563 0.349975765364728 no 1209 0.132358766137111 728 378741 YLR208W SEC13
SGTC_424 splitomicin 100 mM 1.11354031946753 0.350281906524483 no 1210 0.132738220935772 651 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_568 1193-0097 7.48 µM 1.10151972414997 0.352363752852789 no 1211 0.135335262433616 715 3646150
SGTC_3279 9140807 49.47 µM 1.09943790854627 0.352724754297741 no 1212 0.135788551650955 712 45595718
SGTC_1154 4088-0362 150 µM 1.09837194001314 0.352909652100983 no 1213 0.136021054980599 769 6618304
SGTC_1320 1313-0481 95.3 µM 1.09032294909219 0.354306910410164 no 1214 0.137785454766007 742 6813365 YLR208W SEC13
SGTC_2742 clothiapine 36.27 µM 1.09026267621973 0.354317380861984 no 1215 0.13779872567551 663 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM 1.08742518438627 0.354810427302148 no 1216 0.138424473066246 646 5370536
SGTC_142 0335-0849 62.6745 µM 1.08724809250455 0.354841207102591 no 1217 0.138463590947677 825 3889043 YPR107C YTH1
SGTC_794 k038-0031 316 µM 1.08273652961701 0.355625667163223 no 1218 0.139462692442868 799 6624242
SGTC_2270 7924575 90.91 µM 1.08139781420096 0.355858557759 no 1219 0.13976009677057 752 1262135
SGTC_3220 9131269 49.47 µM 1.08084549171434 0.355954658623125 no 1220 0.139882924345895 719 17722206
SGTC_250 brefeldin a 552.239 µM 1.08001082994778 0.356099902227076 no 1221 0.140068678777107 620 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_663 1486-0733 13.9 µM 1.07736531542793 0.356560399141677 no 1222 0.140658546543044 762 722445 YPR165W RHO1
SGTC_2558 carylophyllene oxide 100 µM 1.07682005277301 0.356655337426546 no 1223 0.1407803324641 769 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_554 4483-2211 187 µM 1.07275441981582 0.357363503832743 no 1224 0.141690658203548 724 747107
SGTC_1441 4106-0040 13 µM 1.07218682702748 0.357462408316699 no 1225 0.141818062961555 735 2904180
SGTC_1985 st071382 65.5 µM 1.07018521052301 0.357811271451092 no 1226 0.142267975017897 743 6123237
SGTC_1319 1306-0155 43.7 µM 1.0700435951385 0.357835958198401 no 1227 0.142299843065728 767 3122360
SGTC_1234 0326-0494 15.5 µM 1.06662907986467 0.358431364813897 no 1228 0.143069681827065 745 1547813
SGTC_2432 5630864 12.22 µM 1.0627905397306 0.359101121931748 no 1229 0.143938475319761 719 5714970
SGTC_3070 9117005 49.47 µM 1.05989512143602 0.359606607841783 no 1230 0.144596157678406 682 8779016
SGTC_811 0416-0114 265 µM 1.05946884254195 0.359681048941364 no 1231 0.144693155869442 718 6612453
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.05753771814862 0.360018347922971 no 1232 0.145133125009287 662 61125 An anti-inflammatory.
SGTC_1839 st053978 48 µM 1.05659534440405 0.360182986811785 no 1233 0.145348153083577 741 3788398
SGTC_2369 9071472 200 µM 1.05574492213355 0.360331583437356 no 1234 0.145542383818969 763 17296037
SGTC_1351 1496-0003 46.5 µM 1.04854007696059 0.361591350482298 no 1235 0.147194923853246 788 3891978
SGTC_629 3448-6466 76.7 µM 1.04761483560616 0.361753238012039 no 1236 0.147408049721152 764 573744
SGTC_2058 5236698 133 µM 1.03564211202674 0.363850302560765 no 1237 0.150184568938585 736 766665
SGTC_414 piperonyl butoxide 100 µM 1.03250515916803 0.364400428736486 no 1238 0.150917766018914 748 5794 A potent inhibitor of cytochrome P450.
SGTC_2005 4024620 188 µM 1.03139860773475 0.364594550951003 no 1239 0.151176966745198 774 236743
SGTC_611 3453-1652 23.7 µM 1.02849907183624 0.365103380868339 no 1240 0.151857563606216 801 1560575
SGTC_506 n9-isopropylolomoucine 153 µM 1.02482056768565 0.365749251187496 no 1241 0.152723929883572 795 6610355
SGTC_1849 st056239 19.2 µM 1.02330092812238 0.36601618014639 no 1242 0.153082792531895 767 5393181
SGTC_802 4112-3352 742 µM 1.02191860440504 0.366259045532316 no 1243 0.153409713128839 829 704594
SGTC_2469 5655019 90.81 µM 1.02144834953981 0.366341678506715 no 1244 0.153521034106363 839 2788239
SGTC_1488 4013-0813 75.9 µM 1.02116248019755 0.366391914368729 no 1245 0.153588732601611 739 2910057
SGTC_1064 honokiol 6.76 µM 1.01803430457008 0.366941778568616 no 1246 0.154330826875635 790 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2146 5545642 200 µM 1.01302679657168 0.367822555993123 no 1247 0.155523680852607 797 825326
SGTC_1579 chlormadinone acetate 49.4 µM 1.01238649316403 0.367935230082685 no 1248 0.1556766469378 822 45114258 A steroidal progestin.
SGTC_321 4534-3890 65.3 µM 1.00702535559069 0.368879073669494 no 1249 0.15696129480783 799 699746
SGTC_2976 9009005 19.48 µM 1.00690513143981 0.368900248567355 no 1250 0.156990182912011 812 2993148
SGTC_2112 5488546 200 µM 1.00328152826439 0.36953865479475 no 1251 0.157862522979589 796 600757
SGTC_2922 7999257 32.47 µM 1.00315163626032 0.369561545852693 no 1252 0.157893851944891 731 2988377
SGTC_1885 st057546 99.9 µM 0.993626140116868 0.371241493245544 no 1253 0.160202456554232 846 702008
SGTC_648 0375-0473 33.3 µM 0.993233328556259 0.371310823717143 no 1254 0.160298129939653 836 1713139
SGTC_1150 3909-7983 10.9 µM 0.990762390748427 0.37174703507446 no 1255 0.160900808883081 809 23965914
SGTC_2290 7904846 200 µM 0.988849037530306 0.372084925441294 no 1256 0.161368503886405 790 2962154
SGTC_36 0335-0881 14.2 µM 0.981124861965593 0.373449982571472 no 1257 0.163265585744182 863 23828853
SGTC_274 sirtinol 40.1 µM 0.980023772944848 0.373644702683332 no 1258 0.163537192007633 821 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1874 staurosporine 7.6 µM 0.977156209308316 0.374151963123236 no 1259 0.164245911853066 856 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1747 st037496 66.6 µM 0.975402903746168 0.374462223245595 no 1260 0.16468022193453 842 723305
SGTC_3164 9100705 49.47 µM 0.973999066438426 0.374710701050292 no 1261 0.16502850137859 795 17174235
SGTC_1355 1499-0035 1.68 µM 0.970451185367154 0.375338904151334 no 1262 0.165910822800258 810 1548538
SGTC_356 1634-0012 32.5 µM 0.970406269947608 0.375346859192439 no 1263 0.165922012309501 861 735457
SGTC_2770 toltrazuril 17.5 µM 0.970282565359591 0.375368768982017 no 1264 0.165952832613419 878 68591 Kills coccidiodes.
SGTC_353 1988-1175 58.3 µM 0.970020928740938 0.375415109761855 no 1265 0.166018030095501 775 2788357
SGTC_773 4358-1457 44.6 µM 0.968295651039163 0.375720733967701 no 1266 0.166448368061268 893 1186886
SGTC_1515 3460-0031 42.1 µM 0.967368675462306 0.375884975217687 no 1267 0.166679881780753 774 2876596
SGTC_233 rapamycin 362 pM 0.965368396338316 0.376239460644576 no 1268 0.16718016250731 893 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2934 9036370 36.88 µM 0.959532446601315 0.377274291673209 no 1269 0.168645291038725 868 6462800
SGTC_1321 1326-2144 215 µM 0.959087567032326 0.37735321401957 no 1270 0.168757316618448 848 3513030
SGTC_2585 alliin 100 µM 0.957442216121588 0.377645146382138 no 1271 0.169172049484376 846 87310 A garlic compound which reacts with lipids.
SGTC_333 3486-0131 40.1 µM 0.957202436865959 0.377687695927867 no 1272 0.169232543665466 897 6744690
SGTC_2185 6113692 200 µM 0.955620671966307 0.377968422006862 no 1273 0.169631956859432 783 874150
SGTC_787 4152-0075 138 µM 0.954399252342855 0.378185239379817 no 1274 0.169940792285854 834 9566539
SGTC_3263 9137018 49.47 µM 0.952719483912163 0.378483482094557 no 1275 0.170366109359279 793 43844957
SGTC_75 0159-0059 199.013 µM 0.950889584760235 0.378808462894481 no 1276 0.17083021474645 830 5377270
SGTC_2799 7812892 81.82 µM 0.948782995895882 0.379182688494398 no 1277 0.171365495951546 877 20205235
SGTC_609 0986-0026 86.3 µM 0.946932072859889 0.379511589746562 no 1278 0.171836696705108 854 2848610
SGTC_181 1447-1644 8.07 µM 0.945030460984712 0.379849589017426 no 1279 0.172321662485781 864 534600
SGTC_1314 1222-0010 41.1 µM 0.945026642198272 0.37985026787459 no 1280 0.172322637263973 870 3526027
SGTC_3055 9094636 49.47 µM 0.94052892630091 0.380650073309624 no 1281 0.173473159649367 838 25236176
SGTC_931 2812-0076 566 µM 0.937280147031347 0.381228104515876 no 1282 0.174307236166752 881 3450959
SGTC_627 1391-0720 175 µM 0.936178215479305 0.381424223294302 no 1283 0.174590718713107 841 997839
SGTC_3306 9127676 59.7925 µM 0.935498267075502 0.381545253855664 no 1284 0.174765787992182 835 41905287
SGTC_1795 st049545 62.3 µM 0.935138013960559 0.381609383470309 no 1285 0.174858589077558 880 5291882
SGTC_136 0097-0015 404.482 µM 0.933146370065337 0.381963979898095 no 1286 0.175372200135805 959 4861337
SGTC_1684 st024538 14.6195 µM 0.931656540489923 0.382229297034294 no 1287 0.175757026500319 890 6732859
SGTC_914 3820-6779 408 µM 0.930089351916591 0.382508450379925 no 1288 0.176162411733325 862 2893481
SGTC_482 fipronil 114 µM 0.929268171948364 0.382654746341707 no 1289 0.176375062760989 866 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_272 doxorubicin 8.13 µM 0.929131471855921 0.38267910154747 no 1290 0.176410478089392 916 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_276 colchicine 750 µM 0.928780819381646 0.382741577753555 no 1291 0.176501343311878 897 2833 A microtubule depolymerizer.
SGTC_3311 9131146 2.8755 µM 0.926816025907774 0.383091703961681 no 1292 0.177011031378388 882 4900406 YPR165W RHO1
SGTC_483 fpl-64176 144 µM 0.926335993750527 0.383177260226638 no 1293 0.177135697982923 835 3423
SGTC_292 k038-0015 474 µM 0.924199998225127 0.38355802834256 no 1294 0.177691098281505 860 46368540
SGTC_2339 9000433 200 µM 0.923582609060741 0.383668106710586 no 1295 0.177851835919083 780 2988954
SGTC_249 wiskostatin 11.211 µM 0.923218534877484 0.383733024288751 no 1296 0.177946665823301 895 2775510 A n-wasp and actin depolymerizer.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.920167061304888 0.384277256571702 no 1297 0.178742732138455 838 5282362
SGTC_504 lovastatin 124 µM 0.919541106165675 0.384388924319484 no 1298 0.178906307596756 829 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1311 1190-0148 100 µM 0.912936853809558 0.385567677974961 no 1299 0.180637876674524 1005 1961333
SGTC_1357 1503-1303 39.5 µM 0.91114463599629 0.385887743174956 no 1300 0.181109585272536 917 292895
SGTC_2723 salbutamol 83.58 µM 0.909925448349497 0.386105517568081 no 1301 0.181430913937383 840 9884233 β2-adrenoceptor agonist
SGTC_1027 k015-0025 8.67 µM 0.909536364306384 0.386175024305777 no 1302 0.181533535869597 892 3598955
SGTC_1375 2910-0797 186 µM 0.906358571746146 0.38674284799203 no 1303 0.182373046518987 890 742508
SGTC_2736 butenafine 14.65 µM 0.905421236397947 0.386910382081963 no 1304 0.182621134715715 921 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2734 clemastine 41.6 µM 0.902797952020215 0.387379365219635 no 1305 0.183316569143502 811 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3022 9087993 49.47 µM 0.902413469979623 0.387448115628696 no 1306 0.183418634158306 926 17173644
SGTC_2773 thioridazine 9.09 µM 0.901766599524221 0.387563792476453 no 1307 0.183590433005457 956 5452 An antipsychotic.
SGTC_220 paclitaxel 373.376 µM 0.894127267647534 0.388930651194042 no 1308 0.185626900724316 849 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1852 st056254 31.4 µM 0.893058715710199 0.389121950701156 no 1309 0.185912865008088 903 442583
SGTC_92 0063-0024 660.874 µM 0.885317555562921 0.39050862640229 no 1310 0.187992692055558 1022 3594437
SGTC_173 1273-0061 2.693 µM 0.878919515301606 0.391655761735127 no 1311 0.189722458277237 900 2847414 YPL266W DIM1
SGTC_1806 st050005 60.3 µM 0.878827188176706 0.391672322432115 no 1312 0.189747491159682 903 5194765
SGTC_2569 tetrandrine 100 µM 0.873641884316585 0.392602723570065 no 1313 0.191156654523152 842 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1464 k208-0027 110 µM 0.871103062373015 0.393058489683007 no 1314 0.191848941092307 960 X1464
SGTC_2341 7987486 176.74 µM 0.870797537874158 0.39311334695241 no 1315 0.191932354930508 976 1258686
SGTC_2383 9036125 200 µM 0.86588910295519 0.39399495225232 no 1316 0.193275489745584 921 79580
SGTC_2496 diffractaic acid 79.83 µM 0.864805820165587 0.394189594329559 no 1317 0.193572688068451 968 94870 An apoptosis inducer which activates caspases.
SGTC_3264 9137442 49.47 µM 0.863903199511002 0.394351795583805 no 1318 0.193820534535366 928 17015726
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.862977579917879 0.394518148783338 no 1319 0.194074896967491 994 6708739 YPR165W RHO1
SGTC_2646 retinol 96.75 µM 0.862234751801978 0.394651664447692 no 1320 0.194279174892107 941 445354 A vitamin A analog and teratogen.
SGTC_2433 5607874 27.82 µM 0.861174144442363 0.394842319087026 no 1321 0.194571069025763 956 2252428
SGTC_1491 4138-0063 26.5 µM 0.86010636307162 0.395034288766879 no 1322 0.194865206989243 951 23883227
SGTC_1089 terbinafine 2.25 µM 0.858593807310236 0.395306265234752 no 1323 0.195282327933386 955 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_756 0508-1999 28.3 µM 0.852167126489433 0.396462430185407 no 1324 0.197060669696546 912 6753853
SGTC_1590 st077108 57.8 µM 0.851701823353622 0.396546174075655 no 1325 0.19718980418245 975 5489485
SGTC_2958 9077254 16.72 µM 0.843530210303549 0.398017651541307 no 1326 0.199465988628591 961 16457351
SGTC_615 k087-0205 167 µM 0.842487699209662 0.39820548329593 no 1327 0.199757511073275 949 9642773
SGTC_1468 k284-1086 134 µM 0.836905744229454 0.399211597971075 no 1328 0.201322775639495 1035 15996457
SGTC_2918 7977171 22.06 µM 0.836491249739706 0.399286334973343 no 1329 0.20143929867207 979 2236483
SGTC_1678 st019265 80.2 µM 0.835459033798765 0.399472468623718 no 1330 0.201729651666183 1022 5367020
SGTC_215 1287-0124 461.5 µM 0.834909174130586 0.399571631032937 no 1331 0.201884424478722 979 5560863
SGTC_2176 5809774 33.9695 µM 0.834633331530025 0.399621379287685 no 1332 0.201962094577856 1020 2870539
SGTC_2127 5253358 187.912 µM 0.83355970802446 0.399815022957552 no 1333 0.202264569269553 906 20612
SGTC_562 3772-2733 112 µM 0.831059041217801 0.400266150178682 no 1334 0.202970138317295 1054 2876874 YIL048W NEO1
SGTC_193 1273-0060 1.558 µM 0.830860005905968 0.400302062426988 no 1335 0.203026359682968 884 2847393 YHR072W ERG7
SGTC_3304 9125678 46.087 µM 0.830344601796601 0.400395061502408 no 1336 0.203171988733847 953 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2333 9017922 200 µM 0.82677872756272 0.401038639219666 no 1337 0.204181244642585 1016 3163164
SGTC_2582 agaric acid 100 µM 0.825260023292173 0.401312820360973 no 1338 0.20461199134877 1037 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2870 9038528 12.99 µM 0.822626470744951 0.4017883871464 no 1339 0.205360220384755 927 6463316
SGTC_3239 9133757 49.47 µM 0.821482639735178 0.401994985445531 no 1340 0.205685704300204 1021 17036923
SGTC_2869 9037858 32.47 µM 0.815648618779034 0.403049148878563 no 1341 0.207350566933798 1018 27187042
SGTC_1392 3455-1037 33.9 µM 0.814886007687903 0.403186999198966 no 1342 0.207568781593056 1004 981132
SGTC_2028 5153890 36.43 µM 0.808559067118194 0.404331125572464 no 1343 0.209384408762603 1006 2830968 YPR165W RHO1
SGTC_2014 4013930 200 µM 0.807887710366639 0.404452577956997 no 1344 0.209577613338135 1056 64556
SGTC_7 0192-1582 4.227 µM 0.807617533051514 0.404501457221237 no 1345 0.209655395162425 1082 252616
SGTC_354 2783-3500 4.88 µM 0.807406283269502 0.404539676619692 no 1346 0.209716224059663 986 6740761
SGTC_293 4049-0273 38.5 µM 0.802877406206126 0.405359261459149 no 1347 0.211022798120742 974 1380311
SGTC_1796 st049173 110.4 µM 0.801532870842715 0.405602660315723 no 1348 0.211411611185754 1005 94134
SGTC_472 calcifediol 10 µM 0.80099085526817 0.405700790764835 no 1349 0.211568469966076 973 5283731 A vitamin D metabolite.
SGTC_560 2332-1943 155 µM 0.796994514231355 0.406424500013362 no 1350 0.21272710865589 1032 21177716
SGTC_125 0133-0007 11.75 µM 0.789393272007726 0.407801912149358 no 1351 0.214941093485817 1146 26541
SGTC_2239 6685329 187.64 µM 0.789009992601845 0.40787139610145 no 1352 0.215053083095774 1019 805680
SGTC_2108 5365811 200 µM 0.787389151515886 0.408165267133217 no 1353 0.215527047690862 1070 780283
SGTC_2463 5473429 200 µM 0.78730690206969 0.408180180972986 no 1354 0.215551115125466 1016 5399405
SGTC_2860 9025725 38.96 µM 0.78651583847488 0.408323626973133 no 1355 0.215782671894729 998 40546248
SGTC_1266 0828-0227 32.9 µM 0.783079102045874 0.408946963373718 no 1356 0.216790331129431 1023 3913820
SGTC_2418 pentamidine 31.67 µM 0.781958757422529 0.409150215198331 no 1357 0.217119405944125 1088 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_373 0844-0104 25.9 µM 0.777825135927436 0.409900343691321 no 1358 0.218336053731644 1119 5375804
SGTC_2923 7992654 58.14 µM 0.776176203470261 0.410199667739106 no 1359 0.218822477289901 1055 2985126
SGTC_325 2810-4341 181 µM 0.772401970032596 0.410884985773957 no 1360 0.219938193716207 1095 774970
SGTC_1467 k284-1082 293 µM 0.771642856447745 0.411022857091397 no 1361 0.220162992019572 1085 3334705
SGTC_2608 thymoquinone 42.66 µM 0.770427151591501 0.411243678072635 no 1362 0.220523276257339 1013 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_905 2-aminofluorene 215 µM 0.76762093519517 0.411753507301927 no 1363 0.221356210517688 1158 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2903 5923464 63.88 µM 0.767274626986613 0.411816434409882 no 1364 0.221459125431889 1125 2876576
SGTC_1925 st057770 10.1 µM 0.764705383469021 0.412283358242452 no 1365 0.222223499886174 1044 5989122
SGTC_618 k072-0232 33.2 µM 0.762306739427198 0.412719390129227 no 1366 0.222938476252444 1077 5872756 YGL099W LSG1
SGTC_2596 sinensetin 100 µM 0.762144824778926 0.412748827291268 no 1367 0.22298678616308 1060 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2158 5657123 3.6195 µM 0.761015217440526 0.412954211077505 no 1368 0.223323989035105 1085 2858827
SGTC_1082 camptothecin 424.86 nM 0.760095610943862 0.413121430373039 no 1369 0.223598718003016 1092 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3148 9097893 49.47 µM 0.757190015077401 0.413649881212361 no 1370 0.224468015685749 1066 17174100
SGTC_2981 9013952 38.96 µM 0.75475218974322 0.414093377724432 no 1371 0.225198842760009 1062 2996344
SGTC_411 enrofloxacin 100 µM 0.754225684435205 0.414189175559839 no 1372 0.225356858728915 1159 71188 A bacterial gyrase inhibitor.
SGTC_2492 derrusnin 100 µM 0.753602058314177 0.41430265116787 no 1373 0.225544104009986 1031 1715307 Part of coumarin class of compounds.
SGTC_1115 galangin 695.678 nM 0.753064308453034 0.414400506393484 no 1374 0.225705635406418 1178 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1438 4092-1045 4 µM 0.752505411180321 0.414502215479152 no 1375 0.225873588481449 1126 1351342
SGTC_2156 5649887 115 µM 0.750639246047255 0.414841864907278 no 1376 0.226434897615208 1165 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_889 0919-1524 82.7 µM 0.747173020799208 0.415472900372316 no 1377 0.227479563624182 1065 3905452
SGTC_1356 1502-0781 85.8 µM 0.745195196308605 0.415833066368488 no 1378 0.228076863212283 1058 567702
SGTC_1263 0774-1208 64.8 µM 0.743029767546932 0.416227476575462 no 1379 0.228731829228002 1150 906585
SGTC_2480 5767542 37.17 µM 0.74209732283586 0.416397337641262 no 1380 0.229014185881315 1136 2867358
SGTC_2205 7238770 200 µM 0.740427025749029 0.416701650401577 no 1381 0.229520462600062 1140 279867
SGTC_2310 7668677 200 µM 0.738164887463064 0.417113870745336 no 1382 0.230207128532309 1134 2197143
SGTC_232 clozapine 119 µM 0.728140086925219 0.418941740520277 no 1383 0.233263918459629 1102 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_132 0417-1715 25.805 µM 0.727641134926954 0.419032762895118 no 1384 0.233416646524531 1168 6769098
SGTC_3041 9091929 49.47 µM 0.726422213853896 0.419255145370186 no 1385 0.233789988673976 1230 25236887
SGTC_1721 st082152 9.2685 µM 0.723403262478854 0.419806040007713 no 1386 0.234716083720013 1134 5296051
SGTC_1762 st045503 25.4615 µM 0.72016865241694 0.420396462194882 no 1387 0.235710581072541 1194 4645554
SGTC_1107 amlodipine 47 µM 0.718228937831267 0.420750609599126 no 1388 0.236308068987808 1082 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1854 st056233 32.9 µM 0.717652582515278 0.420855851238494 no 1389 0.236485763585085 1110 5393174
SGTC_1424 4048-1941 275 µM 0.714354777124918 0.421458134242135 no 1390 0.237503914165636 1209 X1424
SGTC_1688 st021091 57.6 µM 0.710126751140611 0.422230573498442 no 1391 0.238812769363669 1177 3656366
SGTC_2104 5389443 200 µM 0.705013119266987 0.423165208088728 no 1392 0.240401035921588 1209 2244536
SGTC_2876 9059903 25.97 µM 0.704419258657906 0.423273777996089 no 1393 0.240585858001642 1171 6916095
SGTC_2502 avocadyne acetate 18.59 µM 0.70411570080256 0.423329276852881 no 1394 0.240680361546249 1192 3952079
SGTC_3346 9158254 43.5805 µM 0.702729735466984 0.423582689350471 no 1395 0.241112096486282 1147 17639500
SGTC_804 1595-0054 20.9 µM 0.698806656341871 0.4243001635184 no 1396 0.242336434063942 1163 761523 Stimulates phospholipase C.
SGTC_2849 9019321 12.99 µM 0.698287775984346 0.424395078037164 no 1397 0.242498621176748 1161 16489627
SGTC_685 1278-0033 54.9 µM 0.698178909448554 0.424414992654364 no 1398 0.242532657192671 1228 3590572
SGTC_2936 9038235 15.59 µM 0.697351661175814 0.4245663249116 no 1399 0.242791372462921 1206 4749415
SGTC_2199 6590217 200 µM 0.69677011069439 0.424672717221608 no 1400 0.24297333708806 1139 703109
SGTC_900 1112-0045 141 µM 0.696597489689891 0.424704298593274 no 1401 0.243027363647835 1124 56211 YIL048W NEO1
SGTC_3046 9092212 49.47 µM 0.696336852895316 0.424751983552495 no 1402 0.243108949515084 1213 25236637
SGTC_2040 5100729 123 µM 0.693319083798441 0.425304181300025 no 1403 0.244054664695072 1195 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2614 arthonioic acid 13.39 µM 0.692866412798445 0.425387024661034 no 1404 0.244196694691221 1162 6710684
SGTC_1196 1588-0294 184 µM 0.68536494301726 0.42676034626751 no 1405 0.246556830111728 1196 6144269
SGTC_463 ikarugamyin 104 µM 0.685292958670997 0.426773529035561 no 1406 0.246579537089398 1246 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1616 st002734 56.1 µM 0.68170941607438 0.427429899962184 no 1407 0.247711356129438 1195 4026101
SGTC_1204 4049-0315 18.3 µM 0.680610286356011 0.427631259751354 no 1408 0.248059058219078 1238 588402
SGTC_2465 5809242 33.21 µM 0.68057862780244 0.427637059855596 no 1409 0.248069077040101 1221 2731748
SGTC_2832 7992762 51.95 µM 0.679593843453426 0.427817488152872 no 1410 0.248380834490629 1128 2985177
SGTC_2744 captopril 92.04 µM 0.677948454861621 0.428118983411189 no 1411 0.248902187894841 1188 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_703 3875-0075 71.8 µM 0.677260707612253 0.428245016261777 no 1412 0.249120278123962 1256 2850814
SGTC_1610 st001799 48.1 µM 0.674902530354389 0.428677218603769 no 1413 0.249868846398223 1162 621897
SGTC_1091 telmisartan 47.6 µM 0.674080871849949 0.428827830769152 no 1414 0.250129949874099 1294 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_652 0437-0092 114 µM 0.673311563438431 0.428968856420227 no 1415 0.250374548865771 1217 3091274
SGTC_1117 retinoic acid 1.10837 µM 0.671953251758171 0.429217877242859 no 1416 0.250806728811602 1248 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2449 5812982 45.77 µM 0.671133747315891 0.429368131555142 no 1417 0.251067665011978 1206 776185
SGTC_2514 salinomycin 42.74 µM 0.669350288796795 0.429695160038783 no 1418 0.251636027250201 1283 23682228 A polyether potassium ionophore.
SGTC_2244 6635614 200 µM 0.668757636786099 0.429803843898746 no 1419 0.251825047141481 1150 836499
SGTC_2358 9037157 4 µM 0.667499592521858 0.430034568755538 no 1420 0.252226534934815 1255 2388925
SGTC_1037 k284-1091 78.7 µM 0.6660957520121 0.43029206079498 no 1421 0.252674949796479 1220 3334711
SGTC_2283 7944793 200 µM 0.664455770238952 0.430592903337841 no 1422 0.25319932417497 1224 2970533
SGTC_650 1328-0195 38 µM 0.661548336399456 0.431126349515031 no 1423 0.254130363519666 1228 2780821
SGTC_1776 st049249 45.9 µM 0.65678019316532 0.432001463993953 no 1424 0.255661130856678 1241 1822314
SGTC_1709 st033179 39.1045 µM 0.656413334518938 0.432068808763127 no 1425 0.255779106527366 1232 573381
SGTC_1703 st026983 48.3 µM 0.65603685075529 0.432137922481243 no 1426 0.255900207017658 1273 1104023
SGTC_2705 st078069 42.8 µM 0.65562662159999 0.432213233437727 no 1427 0.256032196171142 1236 1530061
SGTC_3127 9126946 49.47 µM 0.655566773537815 0.432224220709681 no 1428 0.256051454950075 1206 27243249
SGTC_76 0433-0009 400.328 µM 0.651055721874041 0.433052537344521 no 1429 0.257505258847337 1265 2841569
SGTC_1960 st011366 51.8 µM 0.646052158989732 0.433971632616026 no 1430 0.259122788356843 1277 3972846
SGTC_1267 0828-0272 9.49 µM 0.643064262727637 0.43452064439807 no 1431 0.260091201147725 1323 745334
SGTC_103 0844-0104 51.839 µM 0.640893170826516 0.43491965153932 no 1432 0.260796046566881 1310 5375804
SGTC_1017 4239-0030 168 µM 0.639087930094616 0.43525147239107 no 1433 0.261382865708236 1262 1149593
SGTC_536 3852-0578 10.6 µM 0.638028753108871 0.435446180691376 no 1434 0.261727481627122 1310 2869208
SGTC_2755 lomerizine 42.69 µM 0.635670795931028 0.435879699640743 no 1435 0.262495507508273 1294 3949 A calcium channel blocker.
SGTC_1167 k781-0610 148 µM 0.633290178217875 0.436317462980755 no 1436 0.263272082999562 1316 4525169
SGTC_1509 1326-1131 80 µM 0.631377908160014 0.436669160062696 no 1437 0.263896728651186 1262 768313
SGTC_853 0419-0306 21 µM 0.631359411423717 0.436672562153584 no 1438 0.263902774322766 1240 762713
SGTC_1828 st055811 49 µM 0.627803922093519 0.437326607343074 no 1439 0.265066198240424 1267 5877589
SGTC_2878 9043973 25.97 µM 0.62347652409946 0.43812287890759 no 1440 0.266485712274896 1368 6465167
SGTC_3332 9141069 11.198 µM 0.621100246113578 0.438560237506284 no 1441 0.267266833672607 1279 17332883
SGTC_3031 9088762 49.47 µM 0.619664726679587 0.43882448405106 no 1442 0.267739271538187 1270 205253
SGTC_3121 9125696 49.47 µM 0.618469747746209 0.439044473352758 no 1443 0.268132866806381 1357 1235365
SGTC_3090 9117696 49.47 µM 0.618167175434893 0.439100178305155 no 1444 0.268232572511585 1329 7923821
SGTC_3143 9086658 49.47 µM 0.613842032749216 0.439896588261807 no 1445 0.269659859280687 1367 25236626
SGTC_3082 9117008 49.47 µM 0.611379394633065 0.440350154918844 no 1446 0.270474220336299 1324 41448529
SGTC_1223 0764-0573 147 µM 0.607553357013531 0.441054986446933 no 1447 0.271741872063704 1330 1609797
SGTC_1508 1080-0625 72.9 µM 0.601405326420991 0.442187965069567 no 1448 0.273785025939884 1293 767111
SGTC_1646 st011709 75.6 µM 0.601280171679825 0.442211033927495 no 1449 0.273826696955438 1323 5757843
SGTC_3013 9080133 71.4286 µM 0.60092484588727 0.442276529599367 no 1450 0.273945021880744 1417 17050193
SGTC_921 1561-0023 372 µM 0.60040790161344 0.442371818526444 no 1451 0.274117211532273 1339 24050882
SGTC_1971 st069429 63.5 µM 0.599330460541211 0.442570435177588 no 1452 0.274476269573362 1331 1246522 YGL099W LSG1
SGTC_218 alverine citrate 93.75 µM 0.599087780143018 0.442615173137914 no 1453 0.274557175010033 1361 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1658 st012944 20 µM 0.59883426957593 0.442661908413702 no 1454 0.274641703599781 1289 24207260
SGTC_1702 st027038 51 µM 0.59295349429176 0.443746265919754 no 1455 0.27660613803074 1367 5521182
SGTC_2583 asiatic acid 100 µM 0.590368629483773 0.444223023511526 no 1456 0.277471768724256 1348 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_314 1671-0008 2.74 µM 0.589849776131751 0.444318731602598 no 1457 0.277645684008481 1288 3913060
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.588995276991796 0.444476360250044 no 1458 0.277932220954878 1356 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_601 0986-0029 62.9 µM 0.5888413356985 0.444504758588977 no 1459 0.2779838570217 1354 24747981
SGTC_2889 9059656 51.95 µM 0.582911483450576 0.445598884279427 no 1460 0.279976444864809 1418 3949838
SGTC_38 0929-0051 58.268 µM 0.582187938653606 0.44573241512282 no 1461 0.280220048347049 1404 1379719
SGTC_1943 st076331 65.2 µM 0.577878798539763 0.446527797800207 no 1462 0.281672975101904 1397 24208415
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.577800278964216 0.446542292978351 no 1463 0.281699483462146 1395 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2920 7982904 15.77 µM 0.576362006493871 0.446807819202368 no 1464 0.2821852596921 1356 6456808
SGTC_3045 9092950 49.47 µM 0.5742857546254 0.447191167825746 no 1465 0.282887223694243 1484 44120432
SGTC_1162 k048-0130 20.1 µM 0.571514845646879 0.447702851225203 no 1466 0.283825349978526 1351 6797406
SGTC_3099 9120367 49.47 µM 0.570499298219796 0.447890406747437 no 1467 0.284169548980028 1376 24824940
SGTC_154 3389-1638 511.116 µM 0.569716927490136 0.448034906174799 no 1468 0.284434853560556 1270 5238686
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.567499658322663 0.448444460589932 no 1469 0.285187379333446 1409 5379071
SGTC_2796 7949634 45.45 µM 0.567360315677601 0.448470200574793 no 1470 0.285234702930105 1353 2971588
SGTC_1045 1348-1485 165 µM 0.565718494085011 0.448773501371067 no 1471 0.285792580524533 1380 6810614
SGTC_1802 st050112 57.9 µM 0.565483791570633 0.448816861430653 no 1472 0.285872372900035 1360 4662563
SGTC_1046 2001-0062 216 µM 0.563458722686461 0.449191007634118 no 1473 0.286561280011962 1378 739778
SGTC_635 k038-0028 24.7 µM 0.562864785163691 0.449300750494777 no 1474 0.286763480558497 1450 4035102
SGTC_16 erodoxin 22.806 µM 0.562497040030293 0.449368701342077 no 1475 0.286888709886967 1415 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1133 3473-0247 50 µM 0.56155963877548 0.449541918257885 no 1476 0.287208043044474 1347 711311
SGTC_2521 angolensin 13.4 µM 0.560609260815483 0.449717542879335 no 1477 0.287531968469365 1434 821428 A flavenoid.
SGTC_2334 9017922 200 µM 0.559245227429546 0.449969625953448 no 1478 0.287997185239277 1500 3163164
SGTC_2074 5212007 75.395 µM 0.55642031647886 0.450491753681582 no 1479 0.288961776703177 1373 758611
SGTC_749 1000-0129 128 µM 0.552502492710437 0.451216025918977 no 1480 0.290302063525799 1509 708470
SGTC_595 3909-8003 73.7 µM 0.552416486744827 0.451231927324971 no 1481 0.290331518782327 1429 699517
SGTC_1346 1488-2224 62.4 µM 0.546760148053854 0.452277882821862 no 1482 0.292271762679889 1440 3722427
SGTC_2603 homopterocarpin 100 µM 0.545684388507968 0.452476847206352 no 1483 0.292641452487112 1423 101795 A weak amylase inhibitor.
SGTC_741 4582-0002 126 µM 0.544726709701991 0.452653982308988 no 1484 0.292970745951009 1392 2912688
SGTC_2059 5238311 157 µM 0.544055198943871 0.452778192545854 no 1485 0.293201744339637 1396 703021
SGTC_3011 9081274 71.4286 µM 0.541770879581066 0.453200760656575 no 1486 0.293988177249297 1407 6625322
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.54142686812412 0.453264402715287 no 1487 0.294106696067945 1465 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3019 9081971 49.47 µM 0.540794302089738 0.453381430451565 no 1488 0.294324685315774 1511 16451803
SGTC_976 1348-1067 47.6 µM 0.53917570353454 0.453680897321224 no 1489 0.294882811711445 1435 5310671 YGL099W LSG1
SGTC_124 0136-0217 7.121 µM 0.536702233845016 0.454138579976478 no 1490 0.295736656384123 1538 3976905
SGTC_1144 3486-0183 12.5 µM 0.536214251498495 0.454228881829081 no 1491 0.295905242546194 1419 6744069
SGTC_1914 st062367 72.6 µM 0.535241954648917 0.454408813843306 no 1492 0.296241279218284 1416 978205
SGTC_1433 4060-0023 7.6 µM 0.535003615485723 0.454452922013941 no 1493 0.296323678604021 1461 3840627
SGTC_2698 st077697 67.5 µM 0.53436690076698 0.454570758198404 no 1494 0.296543857195413 1379 3154499
SGTC_1338 1486-1223 76 µM 0.533346947659362 0.454759528272998 no 1495 0.296896717330431 1502 3444526
SGTC_2085 5307070 144.047 µM 0.529298682097458 0.455508870308043 no 1496 0.29829913484421 1391 2840351
SGTC_94 0334-0113 514.748 µM 0.528235533372437 0.455705687614131 no 1497 0.298667934804851 1382 6795178
SGTC_2953 9074162 66.49 µM 0.52673087687392 0.455984258403697 no 1498 0.299190245203095 1530 16451992
SGTC_2767 sibutramine 71.45 µM 0.526344855785303 0.45605572950404 no 1499 0.299324311227985 1529 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1261 0712-0010 12.7 µM 0.524171019234637 0.45645823785983 no 1500 0.300079797986617 1535 2840123
SGTC_3180 9109287 49.47 µM 0.523006152898727 0.4566739433419 no 1501 0.300484985740015 1429 18891271
SGTC_2774 tamoxifen 10.92 µM 0.522804944796727 0.456711203581703 no 1502 0.300554999098887 1469 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1966 st070145 16.1 µM 0.522631567749803 0.456743310299609 no 1503 0.300615334134879 1378 3748532
SGTC_357 1325-0123 420 µM 0.521883113691678 0.456881915525357 no 1504 0.300875858114238 1474 1098503
SGTC_2009 4012297 12.05 µM 0.518887240626191 0.45743676968551 no 1505 0.301919687992741 1443 45595307
SGTC_2622 2-methoxyxanthone 59.94 µM 0.517456733895064 0.45770173768551 no 1506 0.302418682115752 1579 71034 A hepatoprotective.
SGTC_2129 girgensonine 121.053 µM 0.51714213729209 0.45776001189318 no 1507 0.302528470343002 1537 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3132 9126706 49.47 µM 0.517132543411305 0.457761789027093 no 1508 0.302531818705532 1478 850858
SGTC_1364 1653-0028 37.6 µM 0.516368379316973 0.457903342581028 no 1509 0.30279857313052 1467 5718652
SGTC_302 1094-0063 18.9 µM 0.514972762345947 0.458161880066911 no 1510 0.303286026780048 1405 5440289
SGTC_1696 st025591 34.7925 µM 0.512361534704466 0.458645656404241 no 1511 0.3041990031864 1471 2787147
SGTC_122 0236-0016 402.397 µM 0.512021069311335 0.458708738199887 no 1512 0.304318131953348 1489 6808838
SGTC_175 3793-3120 23.7 µM 0.511259663606522 0.458849816031645 no 1513 0.304584622788441 1449 5322297
SGTC_2880 9042983 58.44 µM 0.50690661907437 0.459656473309028 no 1514 0.306110170578592 1470 6464714
SGTC_3290 9121031 71.43 µM 0.503821068378276 0.460228353671649 no 1515 0.307193560577746 1443 17014854
SGTC_144 4161-2749 112.381 µM 0.498996811753467 0.461122652723527 no 1516 0.30889081505782 1399 797501 YMR168C CEP3
SGTC_2272 7805186 180 µM 0.498367449516143 0.461239335668635 no 1517 0.3091125375369 1478 2956062 YPR165W RHO1
SGTC_1332 1480-0653 17.5 µM 0.496611683878464 0.461564869955886 no 1518 0.309731456121793 1475 5749438
SGTC_1539 benzyladenosine 56 µM 0.494557435972141 0.461945778140097 no 1519 0.310456276872404 1465 92208 A nucleotide analog.
SGTC_1486 3970-0793 4.53 µM 0.494506632004339 0.461955198891422 no 1520 0.3104742118876 1545 2844330
SGTC_3278 9139605 49.47 µM 0.494345894379204 0.461985005152668 no 1521 0.310530959079841 1541 7958859
SGTC_2030 5175110 200 µM 0.494257377727859 0.462001419262846 no 1522 0.310562211133714 1551 2831986
SGTC_3073 9114972 49.47 µM 0.493556310745748 0.462131424100008 no 1523 0.310809781017434 1564 41905075
SGTC_1342 1486-1464 234 µM 0.490936792807369 0.462617219369855 no 1524 0.311735576642612 1491 3253938
SGTC_2264 7948757 110.76 µM 0.49034146607916 0.462727631802444 no 1525 0.311946144603541 1461 2971411
SGTC_449 xestospongin c 11.1929 µM 0.489719345431755 0.462843016644909 no 1526 0.312166255302321 1551 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2556 citropten 84.59 µM 0.486926141593972 0.463361111118392 no 1527 0.313155336286576 1459 2775 A potential DNA crosslinker.
SGTC_2368 9071271 200 µM 0.485656189897235 0.463596687376637 no 1528 0.313605475100783 1465 27209959
SGTC_1805 st050013 60.3 µM 0.478817002867848 0.464865575164352 no 1529 0.316034409817042 1542 4037144
SGTC_3273 9137859 49.47 µM 0.478409599927725 0.464941172836695 no 1530 0.31617935111748 1564 2377234
SGTC_1867 st057372 64 µM 0.47772343253946 0.465068500887344 no 1531 0.316423531996682 1490 688837
SGTC_2804 7954240 19.48 µM 0.477340580366683 0.465139546070987 no 1532 0.316559809326098 1602 828705
SGTC_70 0141-0289 43.283 µM 0.475964092713738 0.465394987553092 no 1533 0.317049979701452 1612 352408
SGTC_2706 st078239 82.5 µM 0.475777166990977 0.465429677367056 no 1534 0.317116569165726 1493 15434492
SGTC_2357 9067248 200 µM 0.475623672963416 0.465458163098726 no 1535 0.317171253522106 1524 9150235
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.475103704483387 0.465554661213982 no 1536 0.317356529101345 1524 140250 A respiratory chain inhibitor.
SGTC_3253 9135987 49.47 µM 0.474217765796164 0.465719082407098 no 1537 0.317672312894692 1527 4182430
SGTC_3221 9128209 49.47 µM 0.47421471044958 0.465719649458433 no 1538 0.317673402171483 1540 16460723
SGTC_3193 9111931 49.47 µM 0.47395554220951 0.465767749556513 no 1539 0.317765805272372 1555 17087244
SGTC_369 0957-0393 4.5 µM 0.472668348849498 0.466006652454862 no 1540 0.318224905593866 1471 6997992
SGTC_2895 9054447 58.44 µM 0.472070668337102 0.466117586039943 no 1541 0.318438173964762 1529 2697450
SGTC_499 genistein 192 µM 0.47139008636466 0.466243909907368 no 1542 0.318681097069366 1588 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1668 st014914 51.6 µM 0.470054589657635 0.466491803379312 no 1543 0.319158008224528 1519 2839556
SGTC_2006 4011487 200 µM 0.469685462956228 0.466560322580414 no 1544 0.319289877684138 1648 45595294
SGTC_2211 7117706 200 µM 0.467941599909424 0.466884040795654 no 1545 0.319913176707845 1579 822771
SGTC_2265 7929201 200 µM 0.46615036403227 0.467216575768594 no 1546 0.32055393767575 1457 1265108
SGTC_2161 5662504 8.5105 µM 0.463072306590721 0.467788056756533 no 1547 0.321656269755373 1517 2859334
SGTC_2366 9070441 60.58 µM 0.461850391806176 0.468014939441897 no 1548 0.322094305524197 1484 6837235
SGTC_2653 dihydrofissinolide 100 µM 0.461227564874245 0.468130588699159 no 1549 0.322317673610549 1556 6857746
SGTC_513 4245-1575 41.7 µM 0.461108793887594 0.46815264292652 no 1550 0.322360276436097 1625 719745
SGTC_1662 st014054 52 µM 0.45414212439383 0.469446431581956 no 1551 0.324863267929069 1518 2838777
SGTC_47 0149-0135 24.25 µM 0.452021269072723 0.469840362896944 no 1552 0.325626830096448 1431 5239155
SGTC_1129 3453-1384 223 µM 0.450107019817828 0.47019594420426 no 1553 0.326316637687204 1631 1084452
SGTC_2784 7567673 72.73 µM 0.448199604700759 0.470550279677095 no 1554 0.327004573996139 1542 3471247
SGTC_3344 9148862 3.898 µM 0.446334865257582 0.470896709946319 no 1555 0.327677687503844 1631 4905352
SGTC_2826 7992541 19.48 µM 0.444455937760901 0.471245798341115 no 1556 0.328356489334043 1609 2985066
SGTC_1789 tunicamycin 25 nM 0.444278396947254 0.471278785027546 no 1557 0.328420659018506 1522 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1300 1094-0077 113 µM 0.444129583050942 0.471306434468742 no 1558 0.328474449653482 1527 5532636
SGTC_830 4076-0286 57.8 µM 0.443753241019298 0.471376358977994 no 1559 0.328610499027204 1590 6866659
SGTC_3023 9089636 49.47 µM 0.443620697688778 0.471400985795294 no 1560 0.328658419461542 1635 17249241
SGTC_2972 9093619 59.92 µM 0.440215844795892 0.472033651530376 no 1561 0.329890392443032 1499 25236256
SGTC_1199 1638-0010 4.46 µM 0.436702381770675 0.472686572401547 no 1562 0.331163600853631 1542 3111136
SGTC_2327 6189656 200 µM 0.436512342629525 0.472721890242503 no 1563 0.331232523067139 1686 5349088
SGTC_836 0330-0104 1.35 µM 0.433775317933691 0.473230576488217 no 1564 0.332225803336405 1601 46494820
SGTC_3301 9125354 19.7965 µM 0.433255645212991 0.473327164557909 no 1565 0.332414528699212 1543 41905162
SGTC_3342 9147791 14.508 µM 0.433155020322953 0.473345867210122 no 1566 0.332451076743585 1546 1838168
SGTC_2227 7312221 64.1025 µM 0.432253909146677 0.473513354915977 no 1567 0.332778441006404 1613 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2714 st079313 56.9 µM 0.429388255687443 0.474046019089082 no 1568 0.333820349574854 1584 2939799
SGTC_3333 9141820 12.094 µM 0.429043193256962 0.474110162022215 no 1569 0.33394589576656 1566 1939433
SGTC_2125 5246583 200 µM 0.42896677875626 0.474124366644679 no 1570 0.333973700639905 1736 835267
SGTC_2234 tolnaftate 200 µM 0.426022381825838 0.474671722811714 no 1571 0.335045768520593 1606 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_300 r073-0011 5.04 µM 0.425656611206912 0.474739722032207 no 1572 0.335179041331411 1612 2735780
SGTC_2453 5731132 22.18 µM 0.415592594808381 0.476610972246056 no 1573 0.338854073163152 1737 1362040
SGTC_3116 9124943 49.47 µM 0.413684263988307 0.476965856672612 no 1574 0.339552676459131 1514 41905195 YPL160W CDC60
SGTC_2079 5212404 121 µM 0.409838506440965 0.477681091588456 no 1575 0.340962208609139 1719 758462
SGTC_1016 4226-1401 38 µM 0.409454395361373 0.477752532646574 no 1576 0.341103113923414 1584 2901613
SGTC_957 1187-1561 14.1 µM 0.409393430311448 0.477763871639851 no 1577 0.341125480064226 1595 1538454
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.403240208112043 0.478908410921862 no 1578 0.343385761535508 1597 688803
SGTC_2728 chlorpromazine 9.18 µM 0.397690275311801 0.479940883927275 no 1579 0.345429253320452 1658 2726 A thorazine and dopamine antagonist.
SGTC_3091 9116372 49.47 µM 0.396801383558387 0.480106260189346 no 1580 0.345756965191525 1641 17169793
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.392409155649983 0.480923473784544 no 1581 0.347377961107522 1609 390807
SGTC_3236 9132701 49.47 µM 0.391889903762568 0.481020090645159 no 1582 0.347569781586267 1591 24282524
SGTC_2075 5212009 200 µM 0.391417038486449 0.481108077349321 no 1583 0.347744500025159 1716 780898
SGTC_715 0868-0130 184 µM 0.390537355351575 0.481271763667537 no 1584 0.348069619140476 1801 2876258
SGTC_3340 9146634 11.102 µM 0.38986653858123 0.481396587471634 no 1585 0.34831761912936 1626 4907387
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.389084516659801 0.481542106336739 no 1586 0.348606813384244 1629 3256 An antibiotic and ribosome inhibitor.
SGTC_1025 k007-0731 70 µM 0.387364947970057 0.481862092797782 no 1587 0.349243024796527 1620 6256118
SGTC_3201 9113999 49.47 µM 0.386838372188069 0.48196008315845 no 1588 0.349437933812704 1727 16649224
SGTC_2400 5203494 178.7 µM 0.386246840976475 0.48207016235894 no 1589 0.349656933063748 1602 6777674
SGTC_1149 3909-7961 23.3 µM 0.38305624125027 0.482663930663846 no 1590 0.35083903198171 1596 735261
SGTC_3309 9129340 25.759 µM 0.382640121253766 0.482741373157424 no 1591 0.350993308839699 1703 17158987
SGTC_1317 1273-0028 910 nM 0.380179495873964 0.483199323903795 no 1592 0.351906089258235 1644 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_484 loperamide 105 µM 0.379978974011873 0.483236644318614 no 1593 0.351980511484073 1665 3955 An opioid-receptor agonist.
SGTC_1382 3002-2117 298 µM 0.378546209701981 0.483503309563709 no 1594 0.352512436364872 1774 1497314
SGTC_3017 9080681 49.47 µM 0.378182362913575 0.483571029692196 no 1595 0.352647563295497 1635 16451914
SGTC_2914 7968218 45.32 µM 0.374573473001834 0.484242751195853 no 1596 0.353988852244429 1752 2977111
SGTC_3222 9128301 49.47 µM 0.373106031825206 0.484515898441248 no 1597 0.354534764782482 1643 4911358
SGTC_1247 0448-0043 5.84 µM 0.37150853227548 0.484813262808772 no 1598 0.355129401061855 1668 3089013 YGL099W LSG1
SGTC_487 nimodipine 119 µM 0.37149940750336 0.484814961351408 no 1599 0.355132798585386 1742 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3123 9126162 49.47 µM 0.370615970916695 0.484979411109849 no 1600 0.355461792432378 1670 25239884
SGTC_282 k297-0036 65.7 µM 0.370513006817551 0.484998577814981 no 1601 0.355500143517463 1716 5061378
SGTC_2417 cerulenin 830 nM 0.36986089601239 0.485119968652219 no 1602 0.355743069489732 1673 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1633 st005664 67.9 µM 0.368152775702803 0.485437942832052 no 1603 0.356379660345174 1626 2063822
SGTC_2867 9039098 71.43 µM 0.367963024798864 0.485473266380463 no 1604 0.356450402407477 1650 6463460
SGTC_2460 5552655 174.22 µM 0.367916410522166 0.48548194399378 no 1605 0.356467781684312 1623 5401989
SGTC_927 2425-1185 123 µM 0.367607293517361 0.485539488723151 no 1606 0.356583037821898 1608 730375
SGTC_1956 st077085 54 µM 0.363917715564599 0.486226357590056 no 1607 0.357959727655123 1649 24208685
SGTC_881 0833-0569 170 µM 0.362118275442909 0.486561364622541 no 1608 0.358631823642798 1612 5418700
SGTC_447 ml7 120 µM 0.361482950705474 0.486679647165324 no 1609 0.35886922397371 1762 4216 Selective myosin light chain kinase inhibitor.
SGTC_1683 st010134 710 nM 0.360333546914183 0.4868936421232 no 1610 0.359298857543217 1624 3818134
SGTC_345 1362-0200 395 µM 0.358903217169144 0.48715994488413 no 1611 0.359833746404734 1624 1419823
SGTC_2440 5628896 157.78 µM 0.358126214884201 0.487304611733116 no 1612 0.360124430860721 1692 5522048
SGTC_3028 9087778 49.47 µM 0.356378555578314 0.487630007282748 no 1613 0.360778543360397 1623 17217395
SGTC_1244 0416-0015 52.5 µM 0.355548626325469 0.487784534167742 no 1614 0.361089311425417 1692 96201
SGTC_1870 st057514 26.5 µM 0.353314430811771 0.48820053442527 no 1615 0.361926364035323 1679 5393161
SGTC_2292 7671323 168.05 µM 0.352275177627259 0.488394044538926 no 1616 0.362315950949289 1675 937504
SGTC_3061 glucosamine 200 µM 0.349988318231578 0.488819869891411 no 1617 0.363173732304177 1819 91431 and experimental redox chemotherapeutic
SGTC_962 1254-0300 21.5 µM 0.34996887763374 0.48882348988919 no 1618 0.363181027255497 1708 7340576
SGTC_849 0386-0493 241 µM 0.349105800606713 0.488984202790095 no 1619 0.363504940982575 1703 726119
SGTC_781 4335-2806 94.4 µM 0.347902416265979 0.489208287030637 no 1620 0.363956735291347 1832 845254
SGTC_1431 4049-0260 9.09 µM 0.347108800682796 0.489356069403807 no 1621 0.364254791044942 1759 3854841
SGTC_1763 st044482 94.5 µM 0.346797267262051 0.489414081704825 no 1622 0.364371815143192 1771 88505
SGTC_1977 st070720 65.3 µM 0.346197525502815 0.489525763448299 no 1623 0.364597137121065 1691 682188
SGTC_598 3937-0236 20.2 µM 0.344382121856521 0.489863826325291 no 1624 0.36527946611089 1767 1379313
SGTC_2134 5324836 1.464 µM 0.341005505841476 0.490492635985194 no 1625 0.366549718422754 1746 699272
SGTC_1927 st060202 13.8 µM 0.340562900305357 0.490575061900209 no 1626 0.366716331372914 1843 688887
SGTC_342 k048-0088 23.3 µM 0.339712840853491 0.49073336861058 no 1627 0.367036395331076 1669 6820570
SGTC_257 daunorubicin 18.5 µM 0.338733887353372 0.490915681087487 no 1628 0.367405104926589 1846 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2762 leflunomide 42.06 µM 0.338273291247829 0.491001459484347 no 1629 0.367578624542179 1727 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1700 st030840 7.9285 µM 0.338058224100546 0.491041512321631 no 1630 0.367659655697764 1842 5499307
SGTC_2274 7947094 46.08 µM 0.335310027167251 0.491553328124998 no 1631 0.368695615273554 1668 2971028
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.334797754932989 0.491648733704362 no 1632 0.368888827092275 1769 66535 A nucleotide analog.
SGTC_1485 3909-9022 254 µM 0.334657769954906 0.491674804589603 no 1633 0.368941630474504 1746 714516
SGTC_1470 k295-0292 231 µM 0.334307660890873 0.491740009264543 no 1634 0.369073705064177 1809 5045612
SGTC_1950 st077106 7.18 µM 0.333883300753055 0.491819042832153 no 1635 0.369233810735232 1678 13831864
SGTC_2904 7225135 42.03 µM 0.333627061568877 0.491866765417665 no 1636 0.369330497500123 1804 4446116
SGTC_2996 9066192 71.4286 µM 0.33320068759721 0.491946174561968 no 1637 0.369491399564341 1624 6472854
SGTC_3267 9137951 49.47 µM 0.332399245998305 0.492095438267223 no 1638 0.369793903908642 1762 16643986
SGTC_1324 1418-0026 34.4 µM 0.331980167695433 0.492173489537116 no 1639 0.369952117227603 1767 1372513
SGTC_1746 st038117 42 µM 0.331298899084632 0.492300373098721 no 1640 0.370209361400706 1724 2898218
SGTC_2206 7254556 146.969 µM 0.327275115701587 0.493049802166547 no 1641 0.37172990590741 1819 4398905
SGTC_1238 0333-0287 48.8 µM 0.327234595713797 0.493057349137563 no 1642 0.371745228202674 1721 7226
SGTC_3345 9148410 3.559 µM 0.325411054841969 0.493396991704886 no 1643 0.372434994936689 1834 4903596
SGTC_3355 9151058 44.0485 µM 0.323388169311399 0.493773768688083 no 1644 0.373200644067971 1772 17015728
SGTC_2343 7990716 14.84 µM 0.32234054430403 0.493968898587008 no 1645 0.373597360485866 1781 6456862
SGTC_3244 9134489 49.47 µM 0.321072313761531 0.494205120244666 no 1646 0.374077795430274 1715 16584271
SGTC_678 1218-2179 85.9 µM 0.32066492100415 0.4942810019879 no 1647 0.374232166747606 1781 6820081 YOR116C RPO31
SGTC_3079 9117512 49.47 µM 0.320381943982715 0.494333709943493 no 1648 0.374339405698059 1803 7185044
SGTC_13 0199-0087 65 µM 0.318835184761321 0.494621814623396 no 1649 0.374925748002474 1791 4589825
SGTC_191 3914-0123 66.505 µM 0.316014369326667 0.495147236501886 no 1650 0.375995800733395 1717 3144412
SGTC_303 1348-1668 34.2 µM 0.315497393522686 0.495243532433025 no 1651 0.376192014878731 1792 5380509
SGTC_1054 3429-0080 167 µM 0.315149982431207 0.495308244079022 no 1652 0.376323890040192 1823 1162877
SGTC_340 k038-0059 454 µM 0.314930644291571 0.495349099867795 no 1653 0.376407156916032 1786 23733424
SGTC_1570 verbenone 133 µM 0.311691337153279 0.495952486237774 no 1654 0.377637556085522 1903 29025 A natural terpanoid with antifungal properties.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.311449663965444 0.495997503137678 no 1655 0.37772940176082 1771 364106
SGTC_2711 st079103 59.1 µM 0.309652872748113 0.496332196232952 no 1656 0.378412472206725 1862 54693780
SGTC_2802 7925815 54.55 µM 0.309368331648585 0.49638519870579 no 1657 0.3785206786336 1718 1262923
SGTC_2529 gangaleoidin 93.61 µM 0.309313833994698 0.496395350183044 no 1658 0.378541404306462 1765 4565183
SGTC_1554 st069299 38.7 µM 0.308273635736196 0.496589112155888 no 1659 0.378937062720346 1817 24207999
SGTC_708 3448-5400 146 µM 0.308025329183194 0.496635365351101 no 1660 0.379031529430255 1845 3462195
SGTC_2629 bisabolol 100 µM 0.305312423951165 0.497140713406382 no 1661 0.380064107227104 1814 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3064 1327-0027 10 µM 0.304306370889679 0.497328117755507 no 1662 0.380447245955392 1775 16000455 YPR107C YTH1
SGTC_496 calpeptin 138 µM 0.302618124083937 0.497642600279029 no 1663 0.381090450361124 1748 73364 A calpain inhibitor.
SGTC_552 k242-0005 476 µM 0.300669968641786 0.498005499761581 no 1664 0.381833085630066 1782 4088318
SGTC_336 4111-0029 111 µM 0.299642431415852 0.498196908543355 no 1665 0.382224957423956 1755 3131175
SGTC_3251 9135047 49.47 µM 0.298497125622029 0.498410255643406 no 1666 0.38266188480273 1890 17682963
SGTC_1097 itavastatin 7.23 µM 0.293158808149797 0.499404680279064 no 1667 0.384700383926691 1806 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1242 0402-0103 60.1 µM 0.292047783928105 0.499611643135736 no 1668 0.385125044698593 1786 432868
SGTC_2506 ethyl hematommate 54.16 µM 0.289962996226595 0.5 no 1669 0.385922273359563 1729 3940691 An allergen.
SGTC_561 1550-0330 72.9 µM 0.289688380176841 0.499948844170352 no 1670 0.386027323308219 1761 6812934
SGTC_1809 st050081 57.6 µM 0.286438438893241 0.499343441238068 no 1671 0.387271168731599 1883 5036894
SGTC_69 0096-0274 206.684 µM 0.286008267206672 0.499263308427145 no 1672 0.387435894808754 1878 6741392
SGTC_2757 clomiphene 4.22 µM 0.285298140530039 0.49913102538795 no 1673 0.387707868664466 1932 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3211 9128781 49.47 µM 0.283873822694352 0.498865702476794 no 1674 0.388253539028709 1714 17194361
SGTC_1995 st072814 61.1 µM 0.28345161177518 0.498787052825985 no 1675 0.388415334690003 1769 5769371
SGTC_753 1322-0200 289 µM 0.28244711206953 0.49859993433827 no 1676 0.388800347323735 1815 5403907
SGTC_2900 5328528 85.29 µM 0.28212028532369 0.498539053024539 no 1677 0.388925639650444 1763 795359
SGTC_1502 4534-4282 27.7 µM 0.27898270289823 0.497954585844175 no 1678 0.390129049530211 1817 3278949
SGTC_141 0443-0274 32.331 µM 0.27550870415996 0.497307456386376 no 1679 0.391462719765699 1962 1627241
SGTC_1333 1482-0047 286 µM 0.274466609452543 0.497113338396131 no 1680 0.391863030238281 1932 3811116
SGTC_2983 9022671 12.99 µM 0.272809095227376 0.496804583499767 no 1681 0.392499983848873 1986 6405161
SGTC_1183 1254-0324 198 µM 0.270532882716229 0.496380583201443 no 1682 0.393375161473265 1902 5799357
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.270097723969759 0.496299524683739 no 1683 0.393542536535661 1812 689007
SGTC_831 k061-1017 217 µM 0.269401237097336 0.496169787995756 no 1684 0.39381046713842 1929 1240153
SGTC_399 oxolinic acid 75 µM 0.267813167533881 0.495873975076249 no 1685 0.394421567315258 1829 4628 A DNA gyrase inhibitor.
SGTC_391 gliotoxin 8.33 µM 0.267758213112757 0.4958637386451 no 1686 0.394442718819246 1880 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1896 st058441 89 µM 0.267276593155082 0.495774026789504 no 1687 0.39462810368338 1801 688759
SGTC_878 0828-0289 13.7 µM 0.26698930364497 0.495720513172049 no 1688 0.394738698355001 1803 745350 YLR208W SEC13
SGTC_1685 st024049 53.0905 µM 0.264605656758267 0.4952765126641 no 1689 0.395656630980991 1865 1941139
SGTC_2434 5670830 169.91 µM 0.264330243767997 0.495225212014529 no 1690 0.395762728808488 1829 1549830
SGTC_330 1488-0319 80.1 µM 0.262913222970046 0.494961267534546 no 1691 0.396308732150611 1858 6846614
SGTC_1383 3049-0032 20.7 µM 0.262713788018433 0.49492411952125 no 1692 0.396385594343985 1957 712864
SGTC_2830 7992007 71.43 µM 0.262181712258759 0.49482501194703 no 1693 0.396590675940073 1764 1952075
SGTC_2051 5263410 176 µM 0.262085198928986 0.494807034838122 no 1694 0.396627878799451 1951 227584
SGTC_2144 5628481 200 µM 0.261335922186747 0.494667470751629 no 1695 0.396916733453322 1842 2818399
SGTC_2251 lansoprazole 556 µM 0.261195334134788 0.494641284180187 no 1696 0.396970938043724 1768 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2386 9075165 157.42 µM 0.260960352625874 0.49459751550476 no 1697 0.39706154105686 1865 16452277
SGTC_1571 st070080 73.4 µM 0.258243143148735 0.494091401136555 no 1698 0.39810963169853 1919 4315245
SGTC_46 0329-0187a 2.197 µM 0.25703910586522 0.493867137073474 no 1699 0.398574292429115 1898 46494817
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.256923489424823 0.493845602448608 no 1700 0.398618918575841 1916 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3135 9127742 49.47 µM 0.255519216790289 0.493584045211674 no 1701 0.399161051624749 1816 3643468
SGTC_421 streptovitacin 30 mM 0.25198332243271 0.492925468503584 no 1702 0.400526977361329 1818 91467 include heat shock
SGTC_2729 fluphenazine 10.66 µM 0.250996834474922 0.492741733913805 no 1703 0.400908278295724 1857 3372 An atypical antipsychotic.
SGTC_1395 3486-0190 4.35 µM 0.249139744178104 0.492395852781741 no 1704 0.401626343545966 1993 6748079
SGTC_2874 9043904 71.43 µM 0.248972685147273 0.492364738487798 no 1705 0.401690955161048 1845 4463428
SGTC_1734 st037168 69.4 µM 0.246958325065699 0.49198957306724 no 1706 0.402470238506004 1808 708907
SGTC_2756 carbadox 75.1 µM 0.24505162521126 0.491634465397661 no 1707 0.403208229264616 1850 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1197 1601-0112 267 µM 0.244937328443768 0.491613178742404 no 1708 0.403252478965376 1814 7350313
SGTC_1886 st057356 49.9 µM 0.244384427761988 0.491510206735468 no 1709 0.403466550529009 1812 24207747
SGTC_1842 st055362 61.2 µM 0.242446455467122 0.491149284044768 no 1710 0.404217120798995 1932 676032
SGTC_1386 3228-0095 33.8 µM 0.241617548072195 0.490994912780737 no 1711 0.404538261753333 1955 870181
SGTC_2845 9003024 42.97 µM 0.239261486722167 0.490556140004056 no 1712 0.405451413663476 1964 2990173
SGTC_15 0266-0086 27.098 µM 0.239091050557841 0.490524399862923 no 1713 0.40551749059192 2009 1712902 YIL048W NEO1
SGTC_11 0438-0307 1.3 µM 0.236466182447589 0.490035581235168 no 1714 0.406535472872412 2019 4011476
SGTC_799 1310-0557 151 µM 0.236363321091688 0.490016426078628 no 1715 0.406575377708479 1899 5354492
SGTC_683 panaxydol 45 µM 0.236034168092342 0.48995513035455 no 1716 0.406703078406015 1973 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_385 1494-0393 12.4 µM 0.234818807736344 0.489728804867518 no 1717 0.407174684690359 1923 3090647
SGTC_2446 5162541 200 µM 0.23399680669619 0.48957573297267 no 1718 0.40749372887103 1853 1549321
SGTC_372 0155-0182 15.9 µM 0.232332414127661 0.489265796819842 no 1719 0.408139919144904 1937 771486
SGTC_1283 0922-0125 16.4 µM 0.231534062336531 0.489117133410656 no 1720 0.408449963159352 1956 3360884
SGTC_724 3910-0327 137 µM 0.230980988661212 0.489014144838154 no 1721 0.408664785777183 1849 2885483
SGTC_370 0180-0345 38.7 µM 0.230867210038315 0.488992958062582 no 1722 0.408708982610959 1863 3989527
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.230708887554177 0.488963476803515 no 1723 0.408770484254326 2027 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2713 st079149 53.4 µM 0.230169625661084 0.488863061200075 no 1724 0.408979981725754 1909 3103253
SGTC_128 0906-2981 13.371 µM 0.229234606615419 0.488688953593677 no 1725 0.409343288214626 2013 6740226
SGTC_1235 benzylparaben 21.5 µM 0.22882359687109 0.488612421155885 no 1726 0.409503012836391 1921 7180
SGTC_2406 ethylparaben 405.7 µM 0.228764224485071 0.488601365702131 no 1727 0.409526087088679 1645 8434 A possible steroid mimic.
SGTC_575 k072-0246 11.9 µM 0.226823421940524 0.488239982827686 no 1728 0.410280525128747 1908 6796779
SGTC_714 4296-0578 26.1 µM 0.226345642548732 0.488151020435159 no 1729 0.41046630087577 2032 1589775
SGTC_1049 3226-0134 66 µM 0.22628102193341 0.488138988139363 no 1730 0.410491428959314 1981 5702385
SGTC_2712 st079126 47.7 µM 0.225988066166464 0.488084440195728 no 1731 0.410605351036243 1901 3152970
SGTC_911 3456-4043 236 µM 0.225904257703461 0.488068835221079 no 1732 0.410637943126388 1956 914281
SGTC_2750 bromebric acid 70.15 µM 0.22555574961964 0.488003943882224 no 1733 0.410773480289699 1903 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2072 5231554 129 µM 0.225308488350974 0.48795790464115 no 1734 0.410869648340447 2070 789545
SGTC_1687 st020778 55.3625 µM 0.22372692228423 0.487663426024356 no 1735 0.411484897968321 1932 4259299
SGTC_1454 4239-0054 42.6 µM 0.223308137826707 0.48758545185715 no 1736 0.41164784705219 2020 1340767
SGTC_3065 9113888 49.47 µM 0.222547804904794 0.487443885434393 no 1737 0.411943731617502 1975 16648368
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.222468044586656 0.48742903494836 no 1738 0.411974773355706 2042 756377
SGTC_2474 5321570 43.32 µM 0.222415909918442 0.487419328061164 no 1739 0.411995063827261 2005 2841384
SGTC_2470 5664817 21.68 µM 0.221625031345327 0.487272076308574 no 1740 0.412302897416632 1930 2859561
SGTC_3302 9125395 16.351 µM 0.221329561457847 0.487217063935021 no 1741 0.412417916987455 1918 17599668
SGTC_848 0368-0089 85.6 µM 0.220509729012218 0.487064423840902 no 1742 0.412737098096014 2018 762535
SGTC_438 sphingosine 6.67 µM 0.219923057610512 0.486955195881115 no 1743 0.412965539261023 1738 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2344 7990960 76.95 µM 0.219420881444929 0.486861700234287 no 1744 0.413161102647677 1890 140813
SGTC_1614 st002383 48.6 µM 0.219287595301501 0.486836885011552 no 1745 0.4132130121362 2046 1947235
SGTC_687 k029-0044 34.9 µM 0.216028648514574 0.486230150181318 no 1746 0.414482708245598 2058 5829338
SGTC_2850 9015429 58.44 µM 0.215838791279999 0.486194804455598 no 1747 0.414556704921534 1894 6457570
SGTC_2173 5763948 167 µM 0.214688244274779 0.485980609423279 no 1748 0.415005194295185 2028 2867177
SGTC_1682 st012968 530 nM 0.214583331248071 0.485961078175444 no 1749 0.41504609547445 1836 24207270
SGTC_3293 9120939 62.045 µM 0.21291720493553 0.485650906501886 no 1750 0.415695771233086 1969 934087
SGTC_2977 9011197 71.43 µM 0.211427825472922 0.485373645958796 no 1751 0.416276722941047 2006 2704722
SGTC_1932 st074806 40.9 µM 0.210387515014569 0.485179987583017 no 1752 0.416682618087492 1979 17251235
SGTC_1729 st035615 45.989 µM 0.206568989926395 0.484469182621926 no 1753 0.41817324017358 1894 17385451
SGTC_944 3370-0224 231 µM 0.206044678692086 0.484371587739695 no 1754 0.41837800572386 1889 4580514
SGTC_2419 paclitaxel 166.5 µM 0.205901219629818 0.484344884545164 no 1755 0.418434036367684 1917 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_380 3970-0968 6 µM 0.204470879600189 0.484078647656457 no 1756 0.41899277299119 1921 2891601
SGTC_1013 4112-3890 241 µM 0.203892802290382 0.483971049022608 no 1757 0.419218634937386 1917 705171
SGTC_2856 9022925 19.48 µM 0.203385310566766 0.483876589580634 no 1758 0.419416940170785 1958 4944862
SGTC_1403 3909-7815 62.9 µM 0.202759398438522 0.48376008979383 no 1759 0.419661547026612 1946 6615483
SGTC_1626 st003712 1.76 µM 0.202006712593362 0.483619995702699 no 1760 0.419955738236593 1985 24207035
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.199481561737825 0.483150015400449 no 1761 0.420943032557255 1914 4330530
SGTC_1481 3346-2004 36 µM 0.197338260294475 0.482751123136806 no 1762 0.421781420293842 2061 2770522
SGTC_3170 9103054 49.47 µM 0.196350834940165 0.482567358068908 no 1763 0.422167787582907 1946 16432970
SGTC_2840 9008771 71.43 µM 0.195097110488136 0.482334038675427 no 1764 0.422658462305536 2078 2992978
SGTC_3298 9116858 71.43 µM 0.194178972685744 0.482163176131456 no 1765 0.423017873434863 2023 2506942
SGTC_3114 9122766 49.47 µM 0.19325303752508 0.481990865841826 no 1766 0.423380401792214 1918 17176985
SGTC_2961 9083290 32.55 µM 0.191166460914076 0.481602580386402 no 1767 0.424197589658622 2062 17741490
SGTC_893 0958-0369 48.9 µM 0.188768990538199 0.48115646311083 no 1768 0.425136938410459 2100 6819948
SGTC_2765 myclobutanil 7.74 µM 0.188485767862844 0.481103763057005 no 1769 0.425247935585004 1964 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1767 st044992 70.3 µM 0.186970148415544 0.480821753043258 no 1770 0.425842019150312 1944 9600693
SGTC_1989 st071868 50.2 µM 0.184956172348976 0.480447029114186 no 1771 0.426631705897914 2087 16414057
SGTC_815 1582-0027 36.9 µM 0.18460519956438 0.480381728259153 no 1772 0.426769353690438 2015 3128206
SGTC_2536 dehydroabietamide 32.04 µM 0.183089533551917 0.480099734437559 no 1773 0.427363883989673 2072 3983547
SGTC_941 3237-0776 460 µM 0.182519635439138 0.479993705898289 no 1774 0.427587473156453 2060 760008
SGTC_704 1310-0270 142 µM 0.181992183627107 0.479895575679583 no 1775 0.427794430014619 1935 5718033
SGTC_261 5-fluorouridine 15.376 µM 0.175954725004838 0.478772419848815 no 1776 0.430164755813267 2084 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3159 9100096 49.47 µM 0.174871722609056 0.47857096515612 no 1777 0.430590214980435 2064 25236875
SGTC_1609 st001574 46.4 µM 0.169210513935895 0.477517985699348 no 1778 0.432815530058381 1969 3960012
SGTC_1596 piperlongumine 63 µM 0.166087471127442 0.476937169388154 no 1779 0.434044056904081 2130 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2207 7258803 200 µM 0.16427104200844 0.476599376536498 no 1780 0.434758888560874 2098 3666799
SGTC_2473 5854593 8.94 µM 0.164023943455272 0.476553426064878 no 1781 0.434856147463533 1969 2872951
SGTC_766 1391-0721 126 µM 0.16373338391565 0.476499393982773 no 1782 0.43497051781343 2096 1020919 YIL115C NUP159
SGTC_2356 9061756 188.97 µM 0.159021239036006 0.475623190545031 no 1783 0.436826070211062 2130 20104043
SGTC_1523 st012844 44.7 µM 0.158075476240037 0.475447344014459 no 1784 0.437198662377167 2023 4274103
SGTC_907 3448-6986 75.5 µM 0.155815124337323 0.475027094181281 no 1785 0.438089374369977 2117 590582
SGTC_798 1287-0182 476 µM 0.15501843295243 0.474878978081459 no 1786 0.438403392786736 2143 1649755
SGTC_2855 9016525 58.44 µM 0.151362888640511 0.474199405960542 no 1787 0.439844731348294 2102 43811474
SGTC_2985 9022375 71.43 µM 0.144575121131405 0.472937748630641 no 1788 0.442523170643598 2068 4939335
SGTC_2944 9067346 25.62 µM 0.144026657808341 0.472835816225717 no 1789 0.442739709604872 2067 6473075
SGTC_816 0325-0417 81.3 µM 0.143309178556945 0.472702474744161 no 1790 0.443023003608295 2031 68101
SGTC_1583 clindamycin 39.6 µM 0.142415523818897 0.472536395828308 no 1791 0.443375900566081 1967 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1170 0310-0127 64.8 µM 0.14145374560184 0.472357662018692 no 1792 0.443755749104156 2086 774975
SGTC_2423 st077119 87.2 µM 0.141130899660552 0.472297666600199 no 1793 0.443883266774994 2153 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3187 9109394 49.47 µM 0.13739877359144 0.471604160523794 no 1794 0.445357800193506 2029 17098090
SGTC_973 1325-0077 65.9 µM 0.136165487602716 0.47137500934672 no 1795 0.445845228955583 2118 2835149
SGTC_2819 7996655 46.38 µM 0.135700286175374 0.47128857487411 no 1796 0.446029110739413 2134 6456960
SGTC_644 1498-1197 63.3 µM 0.135636992361678 0.471276814981503 no 1797 0.44605413000299 2121 6741615
SGTC_464 bw-b 70c 158 µM 0.13502787853892 0.471163643857902 no 1798 0.446294916146666 2155 5353454
SGTC_789 1309-1135 70.6 µM 0.1347627501977 0.471114384707272 no 1799 0.446399729072903 2171 3092424
SGTC_2379 9035213 200 µM 0.134093376022944 0.470990021233465 no 1800 0.446664368753455 2209 646551
SGTC_2215 7188065 200 µM 0.129844443549703 0.470200675713969 no 1801 0.448344749831249 2167 940217
SGTC_2362 9071156 126 µM 0.128020023263645 0.469861779745108 no 1802 0.449066563575808 2150 653133
SGTC_1744 st037937 38.9 µM 0.125382586278412 0.469371900166599 no 1803 0.450110336727249 2128 1016152
SGTC_2788 5282734 71.43 µM 0.123001743044623 0.468929720302965 no 1804 0.451052858849753 2162 743706
SGTC_466 geldanamycin 89.2 µM 0.122668646816702 0.468867859363631 no 1805 0.451184746264579 2199 5288382 HSP90 inhibitor.
SGTC_3209 9113616 49.47 µM 0.122100057366757 0.468762265556679 no 1806 0.451409888223843 2229 16649353
SGTC_1031 k035-0009 16 µM 0.117109668615033 0.467835586256441 no 1807 0.453386574006733 2190 5180959
SGTC_2823 7987624 58.44 µM 0.116880102439509 0.467792961623157 no 1808 0.453477533010546 2116 2239440
SGTC_2988 9073640 71.4286 µM 0.114278041501828 0.467309850641351 no 1809 0.454508694397201 2147 9102229
SGTC_1034 k072-0165 12.7 µM 0.11390966252597 0.467241459527033 no 1810 0.454654702919461 2195 5835461
SGTC_2483 5729050 27.16 µM 0.111571637801537 0.466807417981975 no 1811 0.4555815306676 2194 2865180
SGTC_2320 7373003 200 µM 0.110707477816637 0.466647001354154 no 1812 0.455924157997511 2092 5415828
SGTC_2099 5377090 177.372 µM 0.108565949237903 0.466249486341034 no 1813 0.456773384820646 2104 2243829
SGTC_1941 st076221 61.8 µM 0.106420841533784 0.465851340715082 no 1814 0.457624228910876 2243 2828568
SGTC_2218 6965428 192.983 µM 0.105792212972955 0.465734669715676 no 1815 0.45787360763264 2193 675684
SGTC_587 k089-0003 57 µM 0.105517164735719 0.465683622765425 no 1816 0.457982725265129 2227 9659696
SGTC_3295 9122362 53.5725 µM 0.10362990887149 0.465333377090567 no 1817 0.458731525798164 2094 4730473
SGTC_2885 9057732 51.95 µM 0.103166301257549 0.465247342742746 no 1818 0.458915492432993 2152 6471414
SGTC_172 1112-0046 2.638 µM 0.101608182302213 0.464958205518557 no 1819 0.459533842264613 2127 2802135 YIL048W NEO1
SGTC_3241 9133421 49.47 µM 0.100913021771334 0.464829211836618 no 1820 0.459809752999941 2217 17018221
SGTC_2730 imipramine 71.33 µM 0.0986433824120376 0.464408084360833 no 1821 0.460710711894716 2247 3696 A tricyclic antidepressant.
SGTC_1540 guanosine 70.6 µM 0.0980002917845636 0.464288767286956 no 1822 0.460966030836819 2208 6802 Guanosine is a purine nucleoside
SGTC_3207 9114163 49.47 µM 0.0974103817730749 0.464179320006225 no 1823 0.461200250238099 2250 849233
SGTC_3233 9132340 49.47 µM 0.0962996693886114 0.463973254497359 no 1824 0.46164128682881 2163 17682950
SGTC_1445 4239-0156 97.7 µM 0.0962574477154773 0.463965421489197 no 1825 0.461658052951716 2228 4008346
SGTC_868 0527-0199 213 µM 0.0949511517860945 0.463723083042843 no 1826 0.462176813383925 2113 2849450
SGTC_3177 9107506 49.47 µM 0.0948103635506428 0.463696965412097 no 1827 0.46223272751678 2235 8897194
SGTC_3242 9133940 49.47 µM 0.0943408628324228 0.463609869448031 no 1828 0.462419195399342 2211 17248444
SGTC_2649 anisomycin 9.56 µM 0.0924685778427716 0.463262563689169 no 1829 0.463162877741824 2175 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2568 diosmetin 100 µM 0.0921074201797383 0.463195572755151 no 1830 0.463306346532751 2256 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_746 1095-0025 46.6 µM 0.0908377563203755 0.462960071808858 no 1831 0.463810754424479 2229 6749286
SGTC_2378 9074213 121.43 µM 0.0892981363736125 0.462674516044617 no 1832 0.464422487556415 2240 657714
SGTC_671 0560-0003 407 µM 0.0886552157345864 0.462555278214088 no 1833 0.464677962495462 2202 3238678
SGTC_3108 9121785 49.47 µM 0.0885509449339708 0.462535940181352 no 1834 0.464719397563672 2264 17140271
SGTC_688 0527-0193 473 µM 0.0883231006962597 0.462493684562666 no 1835 0.464809939500949 2167 4007154
SGTC_2858 9025781 8.96 µM 0.0858735860591196 0.462039428428262 no 1836 0.465783454599845 2260 4894980 YPL153C RAD53
SGTC_1761 st044296 37 µM 0.0850923180520282 0.461894554689068 no 1837 0.466093998732015 2253 1826700
SGTC_1065 prochlorperazine maleate 2.48 µM 0.0848845868415279 0.46185603508655 no 1838 0.466176572737984 2259 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_83 0170-0301 39.027 µM 0.0847021127076185 0.461822199199413 no 1839 0.466249108154069 2259 3089716
SGTC_2534 helenine 20.12 µM 0.0840458670025903 0.461700514892235 no 1840 0.466509982076048 2193 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2722 naftopidil 47.16 µM 0.0837138604430592 0.461638953967579 no 1841 0.466641968394987 2241 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1634 st006576 41 µM 0.0837111206393061 0.461638445954774 no 1842 0.466643057595411 2255 3915356
SGTC_2560 caryophyllene 100 µM 0.0822442430139388 0.461366467374317 no 1843 0.467226245876472 2282 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2611 pyromycin 23.93 µM 0.0795529715319351 0.46086751699764 no 1844 0.468296399944032 2188 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_9 0092-0002 10.449 µM 0.0788226835018038 0.460732135271104 no 1845 0.468586830676917 2268 759368
SGTC_538 2922-0838 53.3 µM 0.0787266852561905 0.460714339332011 no 1846 0.468625009792644 2269 777039
SGTC_2294 7971431 200 µM 0.0783265436413682 0.460640162826337 no 1847 0.468784151773812 2229 5741572
SGTC_2982 9019404 25.97 µM 0.0783146415564409 0.460637956490755 no 1848 0.468788885477884 2136 22333232
SGTC_502 l-744,832 89.3 µM 0.0780273398750962 0.460584698633149 no 1849 0.468903152605232 2280 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_835 0312-0010 67.2 µM 0.0778523737366483 0.460552265052745 no 1850 0.468972742308546 2249 1626196
SGTC_989 1501-0895 10.3 µM 0.0769918559521979 0.460392754166674 no 1851 0.469315011873155 2289 2830112
SGTC_2825 7998094 58.44 µM 0.0761688536043768 0.460240203335867 no 1852 0.469642380952296 2215 2987815
SGTC_1893 st059353 36.1 µM 0.0750666788254475 0.46003591457382 no 1853 0.470080829720984 2126 3112488
SGTC_1073 triclabendazole 3.09 µM 0.0750209293955616 0.460027435116978 no 1854 0.470099029783164 2172 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1127 asiatic acid 681.4 nM 0.0735027923806154 0.45974606539205 no 1855 0.470703011044612 2207 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2644 guaiazulene 100 µM 0.0718223254529401 0.459434633145815 no 1856 0.471371652779226 2252 3515 A coloring agent.
SGTC_817 1391-0715 46 µM 0.0708732053700234 0.459258748615375 no 1857 0.471749334376162 2201 1353946
SGTC_3054 9094397 49.47 µM 0.0704664195693938 0.459183368254421 no 1858 0.471911213694204 2259 2598354
SGTC_131 0141-0277 33.849 µM 0.0703066211559179 0.459153756850036 no 1859 0.471974806315084 2262 1547771
SGTC_642 0335-0876 158 µM 0.0697964274706636 0.459059217056468 no 1860 0.472177845355243 2230 6812350
SGTC_3203 9113543 49.47 µM 0.0690316460044041 0.458917506034426 no 1861 0.472482214852939 2206 17018012
SGTC_2180 6301957 200 µM 0.0660127535207655 0.458358168182314 no 1862 0.473683835880984 2285 845462
SGTC_1036 k216-0215 33.5 µM 0.0653332220650702 0.458232276495811 no 1863 0.473954345728344 2307 622330
SGTC_1108 betulinic acid 729.144 nM 0.0641336521457113 0.458010051424882 no 1864 0.474431903227213 2282 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2782 7736369 71.43 µM 0.0575513402064809 0.456790887552465 no 1865 0.477053005137223 2238 2950836 YOL077C BRX1
SGTC_2436 5633522 8.09 µM 0.0574311320777337 0.456768626566701 no 1866 0.477100882054379 2316 5724242
SGTC_1963 st076565 50.3 µM 0.0556010708836739 0.456429739773712 no 1867 0.47782980569233 2312 4914280
SGTC_1012 4112-3522 18 µM 0.0526428969912054 0.455882018616098 no 1868 0.479008218739937 2319 3112398
SGTC_2931 9014674 55.67 µM 0.0524981441534036 0.455855219024405 no 1869 0.479065887024256 2300 2996810
SGTC_2522 biochanin a 4.94 µM 0.0453956291280569 0.454540505957124 no 1870 0.481895982424207 2307 5280373 A possible chelator.
SGTC_199 4063-0024 41.6 µM 0.0448710829577009 0.454443429254907 no 1871 0.4821050330386 2311 306215
SGTC_1681 tripelennamine 100 µM 0.0426179513897476 0.454026477756384 no 1872 0.483003042675532 2344 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3354 9151612 71.43 µM 0.0391817603386996 0.453390693809069 no 1873 0.484372737805032 2329 27261949
SGTC_2082 5219693 150 µM 0.0376210354298157 0.453101958806358 no 1874 0.484994917972598 2343 2834649
SGTC_1917 st066507 28.5 µM 0.0376102743120592 0.453099968079291 no 1875 0.484999208001321 2268 3156428
SGTC_2053 5265679 138 µM 0.0374427787056801 0.453068982784893 no 1876 0.485065982046905 2341 764595
SGTC_2576 guaiol 23.12 µM 0.0328224550281027 0.452214374630457 no 1877 0.486908085667703 2348 227829
SGTC_3249 9135183 49.47 µM 0.0310398231814698 0.45188470523894 no 1878 0.487618890327886 2320 4902779
SGTC_2564 betulinic acid 100 µM 0.0304037371368417 0.451767079266615 no 1879 0.48787253221541 2350 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_378 3970-0959 8.33 µM 0.0263056672356225 0.451009360076969 no 1880 0.489506767338233 2338 6615653
SGTC_1268 0828-0275 2.46 µM 0.0253876310004951 0.450839642671811 no 1881 0.489872888480606 2342 745337
SGTC_3024 9090631 49.47 µM 0.0243861104587616 0.450654501770437 no 1882 0.4902723136403 2367 25236383
SGTC_806 3966-4455 5.86 µM 0.0191685849944239 0.449690165545351 no 1883 0.492353309269646 2324 714982
SGTC_923 1900-2434 73.3 µM 0.0179637151834174 0.449467515856664 no 1884 0.492833899913172 2373 5910570
SGTC_2663 amphotericin b 100 µM 0.0165103251350534 0.449198962918233 no 1885 0.493413632472384 2372 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.015113456917796 0.448940875838267 no 1886 0.493970832560307 2366 23847180
SGTC_2837 9008476 45.46 µM 0.0148125315264802 0.44888527931955 no 1887 0.494090870983171 2362 2992805
SGTC_2063 5246145 200 µM 0.0135973342478191 0.448660779611608 no 1888 0.494575615618453 2378 711240
SGTC_1410 3909-8106 77.9 µM 0.0116655482427271 0.448303928712406 no 1889 0.495346225133657 2382 1039210
SGTC_2101 5377231 179.231 µM 0.0110146692494038 0.448183703913837 no 1890 0.495605871583384 2376 2844213
SGTC_318 1488-0629 67.2 µM 0.00803365537854048 0.447633137517022 no 1891 0.496795069677526 2371 3662576
SGTC_112 phenothiazine 287.218 µM 0.00770848025982691 0.447573086686372 no 1892 0.4969247917619 2393 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1408 3909-7976 48.8 µM 0.00628703294716282 0.447310598895553 no 1893 0.497491853262273 2394 24152374
SGTC_222 nsc-310342 10.666 µM 0.00542423775120778 0.447151284360457 no 1894 0.497836052833503 2395 432556
SGTC_3027 9089541 49.47 µM 0.00351284379563773 0.446798377198133 no 1895 0.498598580967743 2397 9943819
SGTC_266 formosanin C 406 nM 0.00259740559673162 0.446629371634542 no 1896 0.498963786253251 2399 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3215 9129942 49.47 µM 0.00178835155053452 0.446480014474864 no 1897 0.499286551334562 2403 17682944
SGTC_510 ag-490 170 µM 0.000395235670658994 0.446222853129672 no 1898 0.499842323784356 2403 5328779
SGTC_1945 st075991 56.6 µM -0.000265203369747987 0.446100947698684 no 1899 0.499894199164143 2406 1084980
SGTC_3213 9129884 49.47 µM -0.00114374430482675 0.445938792391826 no 1900 0.499543712138318 2409 17190742
SGTC_1092 toremifene 6.32 µM -0.0020374123166872 0.445773854305396 no 1901 0.499187190646598 2411 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2592 piperlongumine 83.33 µM -0.00437748267248511 0.445342008331828 no 1902 0.498253642657609 2416 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2657 nystatin 74.44 µM -0.00513391627235737 0.445202426884621 no 1903 0.497951872732034 2424 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_188 3229-0966 278.469 µM -0.0080878939687376 0.444657407272981 no 1904 0.496773432313637 2423 5722370
SGTC_1178 0988-0033 191 µM -0.00965680887318658 0.444367979247455 no 1905 0.49614755052285 2440 5392207
SGTC_1145 3546-0597 10.2 µM -0.0102012433335202 0.444267550775543 no 1906 0.495930363306423 2444 875334
SGTC_1358 1509-0022 2.48 µM -0.0121548931210602 0.443907202534374 no 1907 0.495151018619781 2440 3258434
SGTC_1248 0469-0687 58.6 µM -0.0153635576407795 0.443315469163339 no 1908 0.493871068391706 2439 4017482
SGTC_1742 st038235 28.8875 µM -0.0154621828163185 0.443297282966311 no 1909 0.493831727312431 2462 564103 YBR002C RER2
SGTC_3291 9121177 71.43 µM -0.0179305557815234 0.442842161134484 no 1910 0.492847126470273 2454 17015612
SGTC_1334 1486-0610 236 µM -0.0184058227475214 0.442754539429637 no 1911 0.492657553674812 2514 3742339
SGTC_432 NS 1619 61.3 µM -0.0185899780525482 0.442720588733809 no 1912 0.49258409890575 2533 4552 A K+/calcium channel activator.
SGTC_2831 7999036 19.48 µM -0.018724655025994 0.442695760082112 no 1913 0.492530379917368 2458 2988270
SGTC_1169 aniline yellow 25.8 µM -0.019500383776428 0.442552753389933 no 1914 0.492220965446373 2458 6051 A DNA damaging agent.
SGTC_855 0428-0020 25 µM -0.0220719747698471 0.442078730589183 no 1915 0.491195270961171 2462 6812414
SGTC_1503 4585-0012 61.3 µM -0.0245737725351347 0.44161765238676 no 1916 0.490197469732838 2473 2922052
SGTC_939 1165-0479 45.3 µM -0.0247662507621163 0.441582182159101 no 1917 0.490120705393464 2458 1377347
SGTC_3197 9113331 49.47 µM -0.0251174972099129 0.441517455050987 no 1918 0.489980621914856 2473 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2656 pseudo-anisatin 100 µM -0.0252650148191286 0.441490271218225 no 1919 0.489921789573935 2452 6708809 A neurotoxin.
SGTC_2794 7785382 27.27 µM -0.0276587224147702 0.441049208950132 no 1920 0.488967172919303 2434 2205081
SGTC_1318 1280-3875 124 µM -0.0289801055819896 0.440805763437 no 1921 0.488440228687775 2480 373245
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0312975652109419 0.440378859483026 no 1922 0.487516116069258 2474 6708514
SGTC_934 2950-0684 338 µM -0.0319295355692119 0.440262454941193 no 1923 0.487264122332401 2465 1121253
SGTC_720 r052-1644 49.9 µM -0.0339405780995622 0.439892069305258 no 1924 0.486462267585489 2503 1422863 YOR257W CDC31
SGTC_147 4466-0538 29.23 µM -0.0344307608526896 0.439801797399687 no 1925 0.486266827197152 2562 6742687 YHR072W ERG7
SGTC_1301 naphtanilide LB 4.81 µM -0.0374363769658179 0.439248352657364 no 1926 0.485068534182285 2477 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2178 5812956 200 µM -0.0385152127276458 0.439049728118604 no 1927 0.484638451240385 2459 5403383
SGTC_3328 9140624 29.0385 µM -0.0410947966525323 0.438574863023048 no 1928 0.483610161385516 2487 4904392
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0413845464545316 0.438521529673021 no 1929 0.483494666192878 2478 16725076
SGTC_443 clozapine 122 µM -0.0425172540410498 0.438313046411977 no 1930 0.48304317872568 2474 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3162 9099653 49.47 µM -0.0426223937786503 0.438293695528144 no 1931 0.483001272027675 2484 25237511
SGTC_2512 diallyl trisulfide 49.23 µM -0.0443160241973558 0.437982004577415 no 1932 0.482326249380235 2470 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_832 4083-0019 164 µM -0.0443570295838559 0.437974458538334 no 1933 0.482309906668393 2546 1990758
SGTC_1132 3456-3614 2.5 µM -0.0459178454159622 0.437687245329121 no 1934 0.481687865296885 2540 3125502
SGTC_998 3996-0085 177 µM -0.046991897826159 0.437489622850568 no 1935 0.481259842497297 2525 715391
SGTC_1322 1348-1070 12 µM -0.0474437841775632 0.437406481751059 no 1936 0.481079766780859 2480 6758089
SGTC_2098 5376439 882.5 nM -0.0486256492282996 0.437189047321934 no 1937 0.480608814505397 2566 2844116
SGTC_980 1473-0395 201 µM -0.0515956365259037 0.436642725759443 no 1938 0.47942544812938 2492 768876
SGTC_3310 9130229 44.1445 µM -0.0543413492124042 0.436137766393801 no 1939 0.478331603148061 2605 7761258
SGTC_1123 mangostin 811.285 nM -0.0580591029716852 0.435454206611151 no 1940 0.476850775256214 2572 5281650 An antioxidant.
SGTC_1436 4092-1007 8.32 µM -0.0583488105437134 0.435400947990767 no 1941 0.476735394260929 2516 2881121
SGTC_2652 actinonin 100 µM -0.062586291015529 0.434622081824431 no 1942 0.475047973099904 2512 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3247 9135149 49.47 µM -0.0626700904696329 0.43460668169143 no 1943 0.475014607453678 2506 8934436 YOR116C RPO31
SGTC_3179 9107801 49.47 µM -0.0630082566629389 0.434544536658246 no 1944 0.474879964760567 2534 4818259
SGTC_1578 josamycin 24.2 µM -0.0657650560475476 0.434037978212973 no 1945 0.473782438608714 2529 5282165 A P450 substrate.
SGTC_692 k241-0027 77.8 µM -0.0665022457294343 0.433902538847552 no 1946 0.473488984918059 2580 3600480
SGTC_3330 9141424 71.43 µM -0.0675849988972211 0.433703625282714 no 1947 0.473057998619248 2554 27261020
SGTC_27 0485-0001 32.618 µM -0.0706169512240342 0.433146712063862 no 1948 0.471851309483808 2518 2054479
SGTC_1891 st059073 26.2 µM -0.0712401018841276 0.433032267292206 no 1949 0.471603332894858 2556 688754
SGTC_301 4119-0100 24.5 µM -0.0727936876020593 0.432746967890196 no 1950 0.470985147097781 2550 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1798 st045719 60.953 µM -0.0736625009735511 0.432587434880075 no 1951 0.470639468789254 2525 3980186
SGTC_2151 5563267 85.4165 µM -0.0740490500272622 0.432516459606493 no 1952 0.47048567804105 2585 5310824
SGTC_882 0843-0131 351 µM -0.0796610395471562 0.431486274085395 no 1953 0.468253423436578 2537 5425421
SGTC_6 0844-0013 19.835 µM -0.0799238713206433 0.431438037768453 no 1954 0.468148901995416 2571 1584900
SGTC_2808 7946468 45.46 µM -0.080380583595017 0.431354221879559 no 1955 0.467967284488646 2606 2970879
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.082853055088695 0.430900527381842 no 1956 0.466984191123679 2588 676296 Flavone; oxidizing agent.
SGTC_1151 3909-8316 15.3 µM -0.0855207515241068 0.430411111697289 no 1957 0.465923699287637 2651 800431
SGTC_2103 5378138 10 µM -0.0896483238899456 0.429654077994174 no 1958 0.464283341032858 2564 244142
SGTC_733 4069-0007 56.1 µM -0.0917723174839548 0.42926461915942 no 1959 0.463439469335591 2571 5717425 YNL287W SEC21
SGTC_865 0488-0499 301 µM -0.0943992562353937 0.428783034767894 no 1960 0.46239600330329 2560 9634651
SGTC_1469 k284-2957 126 µM -0.0945687819478052 0.428751960045864 no 1961 0.462328673534967 2613 23884841
SGTC_289 k017-0060 526 µM -0.0971039857710302 0.428287300125017 no 1962 0.461321907817546 2592 5512909
SGTC_2191 5911152 200 µM -0.0982590476397763 0.428075629772381 no 1963 0.460863298008219 2592 2875902
SGTC_910 3454-3003 490 µM -0.0982642523817226 0.428074676026484 no 1964 0.460861231616586 2571 820824
SGTC_1521 st012942 49.4 µM -0.0991281032421982 0.427916385010758 no 1965 0.460518279406947 2827 24207259
SGTC_1230 0170-0365 3.77 µM -0.0991449277223955 0.427913302227872 no 1966 0.460511600312458 2662 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2932 9016711 44.54 µM -0.100767580054786 0.427616001126302 no 1967 0.459867481588258 2609 7117328
SGTC_3316 9136639 10.545 µM -0.100988513324229 0.427575525078954 no 1968 0.459779789298244 2677 4903665
SGTC_814 3342-0569 96 µM -0.102697709788374 0.427262417780684 no 1969 0.459101445679611 2590 4346283
SGTC_1783 st039459 87.517 µM -0.103626278013673 0.427092332779062 no 1970 0.458732966544127 2795 729761
SGTC_1218 1348-1416 30.7 µM -0.105429252657529 0.426762122277377 no 1971 0.458017602571524 2580 6787668
SGTC_1632 st005650 90 µM -0.106508769386518 0.426564435914177 no 1972 0.457589349011576 2696 2759605
SGTC_234 nsc-17383 10.7 µM -0.107980668556294 0.426294924298674 no 1973 0.457005513397277 2616 408974
SGTC_1040 k898-0338 155 µM -0.110549686756281 0.425824607592776 no 1974 0.455986723489457 2604 20969351
SGTC_2927 9011802 47.9 µM -0.111653524943219 0.425622557489209 no 1975 0.455549065272345 2690 43912568
SGTC_653 0203-0016 55.2 µM -0.112171181015625 0.425527810774705 no 1976 0.45534383957478 2682 295302
SGTC_1860 st056228 74.6 µM -0.112819565198721 0.425409142929749 no 1977 0.455086803295143 2724 688679
SGTC_362 0310-0100 9.03 µM -0.114964994545332 0.425016532784412 no 1978 0.454236434166072 2701 790235
SGTC_295 k015-0027 31 µM -0.115211213165218 0.424971479919413 no 1979 0.454138855521049 2683 3887424
SGTC_1059 3448-6867 171 µM -0.116029389620664 0.424821777757864 no 1980 0.453814624775067 2576 3934407
SGTC_1781 st038725 66.3 µM -0.116052649313613 0.424817522078421 no 1981 0.4538054077654 2606 4270275 YIL048W NEO1
SGTC_2450 5739737 12.93 µM -0.117334801408744 0.424582948357332 no 1982 0.453297373978072 2685 2262825
SGTC_1207 2099-0101 141 µM -0.118081879117248 0.42444628047179 no 1983 0.453001390680873 2694 5837381
SGTC_2716 st080858 38.6235 µM -0.119553369631474 0.424177117522186 no 1984 0.452418480165152 2675 5296050
SGTC_847 0342-0274 5.54 µM -0.121660232230547 0.423791794807564 no 1985 0.451584054648253 2734 18097
SGTC_1663 st014140 55.4 µM -0.122639495316591 0.423612722804032 no 1986 0.451196288879474 2622 4207120
SGTC_1775 st081588 35.1725 µM -0.123825977610871 0.423395778997244 no 1987 0.450726531471371 2626 1426443 YGL099W LSG1
SGTC_2315 7733312 200 µM -0.124303397715893 0.423308491082171 no 1988 0.450537528589927 2660 726316
SGTC_3014 9081533 49.47 µM -0.125378477082386 0.423111945413002 no 1989 0.450111963224413 2709 21367265
SGTC_3087 9117406 49.47 µM -0.128976237111284 0.422454343493542 no 1990 0.448688225898659 2753 42546093
SGTC_840 0245-0196 390 µM -0.131259882174447 0.422037048716016 no 1991 0.447784863269267 2764 3827528
SGTC_77 0828-0286 12.516 µM -0.131648033206823 0.421966129832959 no 1992 0.447631345562837 2610 745345
SGTC_681 1642-0006 26.6 µM -0.133027287835226 0.421714147388493 no 1993 0.447085899857385 2640 4446530
SGTC_1176 0848-0131 83.3 µM -0.134740288457101 0.421401235969219 no 1994 0.44640860902289 2740 6769040
SGTC_3004 9076122 71.4286 µM -0.139263695865058 0.420575190555575 no 1995 0.444620888390855 2763 44782551
SGTC_3275 9138069 49.47 µM -0.140079024745305 0.420426335749041 no 1996 0.444298776503618 2732 17617007
SGTC_1412 3909-8563 178 µM -0.141933135815626 0.420087872600814 no 1997 0.443566410333068 2723 23767530
SGTC_2995 9067767 71.4286 µM -0.142067195408378 0.42006340265894 no 1998 0.443513464791609 2735 11673567
SGTC_3112 9123419 49.47 µM -0.146117367608748 0.419324269495715 no 1999 0.441914368097686 2646 17015854
SGTC_1453 4237-0541 195 µM -0.146796980498398 0.419200271860015 no 2000 0.441646134039127 2673 739892
SGTC_1171 0368-0077 21.4 µM -0.152640168470572 0.418134495094341 no 2001 0.439341023148926 2687 3239779
SGTC_1895 st058434 18.3 µM -0.153788261382836 0.417925157399774 no 2002 0.438888344892252 2822 5393175
SGTC_634 1611-4317 11.2 µM -0.154175764971605 0.417854507119918 no 2003 0.438735575225564 2669 2843522
SGTC_3321 9137793 26.8275 µM -0.155436692303522 0.417624631173127 no 2004 0.438238529698883 2687 4904192
SGTC_400 oxethazaine 37.5 µM -0.155983822929618 0.417524894152484 no 2005 0.438022886283042 2743 4621 A local anesthetic.
SGTC_518 1021-0119 62.6 µM -0.156649254207421 0.417403599131929 no 2006 0.437760641229057 2740 1097762
SGTC_2466 5983409 37.09 µM -0.15807489995471 0.417143758451603 no 2007 0.437198889427218 2730 2879657
SGTC_1490 4089-0339 670 nM -0.165460823299379 0.415798168966861 no 2008 0.434290641623076 2700 742542
SGTC_446 go6976 132 µM -0.165753015208272 0.415744956760202 no 2009 0.434175661479821 2819 3501 A protein kinase C inhibitor.
SGTC_2868 9035608 32.47 µM -0.169357196228103 0.415088712663094 no 2010 0.43275784478437 2657 6462614
SGTC_153 4077-0274 519.67 µM -0.171709595261243 0.414660518849103 no 2011 0.431832920966584 2892 3121976
SGTC_2743 auranofin 4.32 µM -0.173538533032608 0.414327677736568 no 2012 0.43111407117545 2744 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_283 0987-0079 11.7 µM -0.173763700926593 0.414286704574928 no 2013 0.43102558640703 2788 411556
SGTC_1224 0823-0416 294 µM -0.174168563351521 0.414213035256984 no 2014 0.430866495358519 2836 3598164
SGTC_111 0083-0039 52.457 µM -0.179332805296118 0.413273608409242 no 2015 0.428838194733083 2696 759313
SGTC_1987 st072290 61.9 µM -0.181223336277634 0.412929825883636 no 2016 0.428096139081485 2773 54697379
SGTC_2986 9022445 71.43 µM -0.181494778886254 0.412880471032762 no 2017 0.427989615472556 2921 6459286
SGTC_2846 9008642 19.48 µM -0.181741099386869 0.412835685182327 no 2018 0.427892955202292 2857 2992898
SGTC_754 3474-0146 171 µM -0.18224138390792 0.412744727233928 no 2019 0.427696648542095 2715 24762078
SGTC_2397 5161689 200 µM -0.185016237329964 0.412240309553549 no 2020 0.426608149946292 2913 2259942
SGTC_2323 6148992 148.28 µM -0.185593797109071 0.412135337928227 no 2021 0.426381659122892 2786 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_281 1672-3440 14.9 µM -0.186730547782798 0.411928751594954 no 2022 0.425935951838746 2835 6833000
SGTC_2109 5483026 200 µM -0.18846082363785 0.411614348377161 no 2023 0.425257711705298 2770 759335
SGTC_1625 st003711 30.1 µM -0.189758692076198 0.411378553841593 no 2024 0.424749113317153 2932 24207034 YER133W GLC7
SGTC_972 1319-0219 195 µM -0.191163223241235 0.411123417065908 no 2025 0.424198857916591 2818 23903702
SGTC_2546 rhodinyl acetate 100 µM -0.191885131348259 0.410992295180189 no 2026 0.423916092243087 2753 6708682
SGTC_533 1222-0222 6.71 µM -0.195198024695025 0.410390694230416 no 2027 0.422618962691566 2938 3982874
SGTC_1253 0550-0034 176 µM -0.197828018845523 0.409913253575731 no 2028 0.421589811755988 2872 5969915
SGTC_159 3970-0959 50 µM -0.19933940330824 0.409638942086905 no 2029 0.420998629117469 2856 6615653
SGTC_1791 st048313 56.1 µM -0.200623721566047 0.409405877148047 no 2030 0.420496404027278 2904 1204976
SGTC_419 nsc-638432 893 µM -0.201130728264745 0.409313879568502 no 2031 0.420298177621157 2846 368090
SGTC_3109 9122853 49.47 µM -0.201477921482949 0.409250883408324 no 2032 0.420162445778225 2816 1234709
SGTC_2803 7707263 71.43 µM -0.202803221507762 0.409010437101091 no 2033 0.419644419931644 2792 2199229
SGTC_1922 5578187 25 µM -0.2039179059222 0.408808228829196 no 2034 0.419208826084833 3005 1350412
SGTC_1328 1441-0025 69.2 µM -0.208589188669593 0.407961103763673 no 2035 0.417384475562374 2756 4562601
SGTC_1363 1636-0063 10.4 µM -0.209982576974509 0.407708499487786 no 2036 0.416840635724176 2770 6072185
SGTC_992 3909-8734 162 µM -0.212170598361708 0.407311915401146 no 2037 0.4159869718285 2826 4288319
SGTC_2236 dapsone 200 µM -0.217965606208309 0.406262016412998 no 2038 0.413727954702308 2812 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1345 1488-0192 31.4 µM -0.218457626906344 0.406172906464785 no 2039 0.413536284904732 2901 658348
SGTC_2768 sulfasalazine 50.2 µM -0.219422492848346 0.40599817355234 no 2040 0.413160475081395 2870 5384001 An antioxidant and salicylic acid derivative.
SGTC_902 1120-0002 2.07 µM -0.220232004289806 0.405851589088683 no 2041 0.412845236315645 2775 3280475
SGTC_2704 st078022 71.1 µM -0.221789433943978 0.405569610463138 no 2042 0.412238902560538 2951 54697681
SGTC_1993 st073995 70.8 µM -0.222700637838821 0.405404656205416 no 2043 0.411884252452438 2821 3098394
SGTC_107 0358-0022 2.6945 µM -0.224185049287866 0.405135970791822 no 2044 0.411306658181112 2874 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1153 4055-0057 267 µM -0.224417607724219 0.40509388067492 no 2045 0.411216185543852 2801 882706
SGTC_1221 2958-7315 257 µM -0.22687730469653 0.404648774128906 no 2046 0.410259575070554 2900 4562705
SGTC_1271 0832-2808 169 µM -0.229048992905849 0.404255888140895 no 2047 0.409415418656103 2968 3663794
SGTC_2720 fluspirilene 36.88 µM -0.229207696520839 0.404227180421306 no 2048 0.409353745425518 2900 3396 An atypical antipsychotic.
SGTC_3141 9094609 49.47 µM -0.232249476346793 0.403677056107541 no 2049 0.408172125784293 2779 25236309 YDL196W YDL196W
SGTC_3062 9077494 49.47 µM -0.233087948469167 0.403525446791093 no 2050 0.407846556462903 2937 16459633
SGTC_1588 farnesol 29.9 µM -0.233542551850204 0.40344325320867 no 2051 0.407670065653358 2825 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1664 st014217 9.02 µM -0.236353436770395 0.40293513207517 no 2052 0.406579212360216 2852 3982782
SGTC_1118 chelidonine 707.474 nM -0.236787692380117 0.402856646673311 no 2053 0.406410750063467 2942 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_403 arphamenine a 50 µM -0.236902476286562 0.402835901801278 no 2054 0.406366224434484 2821 5487158 An arginine aminopeptidase inhibitor.
SGTC_2100 5377183 190 µM -0.238273655007163 0.402588110116484 no 2055 0.405834426615653 2924 2844202
SGTC_1289 0976-0073 69.1 µM -0.240723012447815 0.402145573492594 no 2056 0.404884901002547 2938 3391136
SGTC_2806 7952793 58.44 µM -0.241688476048786 0.401971173189046 no 2057 0.404510779833565 2984 2972490
SGTC_2027 5150920 200 µM -0.24554032945451 0.401275573131432 no 2058 0.403019042653912 2911 786715
SGTC_3126 9127922 49.47 µM -0.245676144734469 0.401251052162802 no 2059 0.402966470031914 3089 45595682
SGTC_953 1188-0045 9.7 µM -0.247890991876734 0.400851224296616 no 2060 0.402109374932813 2953 6144426
SGTC_1713 st033146 12.748 µM -0.248322484468676 0.400773342613298 no 2061 0.401942451816513 2980 674619
SGTC_2654 protoveratrine a 100 µM -0.248705397072792 0.400704232613258 no 2062 0.401794336868637 2852 5702278 A heart drug and vasodilator.
SGTC_163 TUB2.036 7.546 µM -0.251749488306188 0.4001549303929 no 2063 0.400617351226595 2945 15992207 YJR013W GPI14
SGTC_2298 7976326 193.81 µM -0.252562915863847 0.400008181859234 no 2064 0.400302994963576 2851 2235818
SGTC_1716 st033144 30.6155 µM -0.254628341355349 0.399635626838929 no 2065 0.399505083644437 3020 674617
SGTC_1994 st072947 40.9 µM -0.257556601362314 0.399107593065339 no 2066 0.398374563481091 2969 5286565 YDL195W SEC31
SGTC_381 3461-2219 42.7 µM -0.258706533917973 0.398900283743268 no 2067 0.397930838909964 2982 2883159
SGTC_108 0509-0257 621.132 µM -0.263903469935731 0.397963738930274 no 2068 0.395927150893192 2960 536624
SGTC_955 1216-0110 33 µM -0.265342652087665 0.397704486206856 no 2069 0.395372755030314 2821 3619719
SGTC_751 0833-0568 350 µM -0.267633196378619 0.397291963223609 no 2070 0.394490837889643 2950 6954252
SGTC_2354 9060492 162 µM -0.268900742620681 0.397063729722031 no 2071 0.394003032741807 3023 6471895
SGTC_1771 st048882 4.1505 µM -0.272207781034123 0.396468432801792 no 2072 0.392731129632743 2870 4580403
SGTC_2978 9011784 42.97 µM -0.274417358085647 0.396070823247899 no 2073 0.391881952505474 3018 2994934
SGTC_3260 9137109 49.47 µM -0.278649605096891 0.395309539888661 no 2074 0.390256870215203 2986 17478346
SGTC_785 1270-0111 65.3 µM -0.278782406889573 0.395285658364879 no 2075 0.390205908335512 2861 6741994
SGTC_2769 toremifene 3.73 µM -0.279940740690376 0.395077373823357 no 2076 0.389761484876825 3095 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2812 7970281 58.44 µM -0.28265362457164 0.394589676953867 no 2077 0.388721184636795 3046 2233435
SGTC_1444 4112-3581 28 µM -0.282930982658788 0.394539825406599 no 2078 0.388614871897069 2914 2877249
SGTC_1298 1079-1278 263 µM -0.284143632126563 0.394321887561018 no 2079 0.388150155372219 2935 2840950
SGTC_3119 9125183 49.47 µM -0.284586033823202 0.394242387183573 no 2080 0.387980656196216 2956 22695334
SGTC_2824 7998404 51.95 µM -0.287244900413887 0.393764677013951 no 2081 0.38696240432278 2892 837851
SGTC_1866 st057638 64 µM -0.28779855914195 0.393665222979844 no 2082 0.386750470182969 2936 688802
SGTC_1128 3448-9350 235 µM -0.288509315134804 0.393537559642483 no 2083 0.38647845053905 3001 619386
SGTC_2421 5690543 90.72 µM -0.290582895537591 0.393165176315476 no 2084 0.385685171621439 3018 3397993
SGTC_196 k015-0023 18.111 µM -0.290724082597734 0.393139824828668 no 2085 0.385631175759142 2911 5211998
SGTC_2235 salicylic acid 500 µM -0.292812091556108 0.39276495581483 no 2086 0.384832892710835 2928 338 A COX inhibitor and kinase inhibitor.
SGTC_2068 5226020 147 µM -0.294839874786706 0.392400994557467 no 2087 0.384058102012049 2974 1810509
SGTC_640 3381-0960 37.1 µM -0.296868975823963 0.392036890953453 no 2088 0.383283271334472 2990 1745025
SGTC_140 0062-0056 502.533 µM -0.297306324945529 0.391958425028655 no 2089 0.383116326620283 2892 3758964
SGTC_1723 st034307 2.5525 µM -0.297567387700453 0.391911589185929 no 2090 0.383016684203903 3007 867466
SGTC_2214 7179297 48.276 µM -0.298430233565309 0.39175680186957 no 2091 0.382687408348995 2936 769744
SGTC_3299 9121982 43.1275 µM -0.299885967579669 0.391495694236768 no 2092 0.382132069130544 2958 17594604 YPL160W CDC60
SGTC_928 2764-0428 58.7 µM -0.301017989224616 0.391292683028901 no 2093 0.381700388470463 3042 662578
SGTC_155 k072-0202 43.6 µM -0.302312906352414 0.391060495254909 no 2094 0.381206770262404 2910 5857737
SGTC_822 1487-0950 154 µM -0.302602582932739 0.391008559512002 no 2095 0.381096372906838 3095 1958375
SGTC_2031 5180455 200 µM -0.304041517549614 0.390750603593187 no 2096 0.380548130506936 2943 29949
SGTC_2520 obtusaquinone 4.71 µM -0.30479657974292 0.390615263807887 no 2097 0.380260543315808 3096 5967872
SGTC_1487 3970-0795 2.82 µM -0.306047722428948 0.390391034130719 no 2098 0.379784155327355 3042 3765103
SGTC_1187 1391-0724 117 µM -0.306464973212638 0.390316262585809 no 2099 0.379625322471907 2986 6997986
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.309193722863079 0.389827369452542 no 2100 0.378587084277328 2931 91467 include heat shock
SGTC_579 4491-1009 110 µM -0.311754229625332 0.389368777800222 no 2101 0.37761365551344 3078 1271041
SGTC_3325 9138760 55.175 µM -0.312273128481274 0.389275860774058 no 2102 0.377416480018328 2986 43844959
SGTC_3285 9112818 20.8695 µM -0.313306649223393 0.389090811447301 no 2103 0.37702384945864 2936 17017947 YPR165W RHO1
SGTC_747 3448-8087 38.7 µM -0.314910484426184 0.388803698548954 no 2104 0.376414810451945 3011 5168703
SGTC_20 0481-0013 4.944 µM -0.321613387616991 0.387604427448536 no 2105 0.373872800217181 3006 182045
SGTC_877 0771-0151 33.1 µM -0.322561243433461 0.387434925047645 no 2106 0.373513774611059 3055 6166523
SGTC_160 3453-0671 289.699 µM -0.323469427600957 0.387272537143223 no 2107 0.373169878651599 2973 5322268
SGTC_185 k048-0037 25.491 µM -0.323503257995193 0.387266488479178 no 2108 0.373157070274779 3111 6827589
SGTC_3139 9095020 49.47 µM -0.324299799693853 0.38712407969023 no 2109 0.372855535658446 2860 25236292
SGTC_315 k915-0449 187 µM -0.324538640039557 0.387081381854093 no 2110 0.372765136688885 3012 20970215 YNL149C PGA2
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.326524420551263 0.386726433932664 no 2111 0.372013807979177 2981 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3146 9095609 49.47 µM -0.32688467419848 0.386662050613314 no 2112 0.371877556554439 3028 17173999
SGTC_230 MPP+ 141.667 µM -0.327575534038907 0.386538591196145 no 2113 0.371616311559267 3024 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_776 4476-4378 112 µM -0.328140045793843 0.386437719212099 no 2114 0.371402888306391 3056 2892008
SGTC_1810 st050138 53 µM -0.328564497397935 0.38636187947591 no 2115 0.371242443203601 3111 3444541
SGTC_965 1291-5240 308 µM -0.328944395240267 0.386294004153226 no 2116 0.371098858648036 3112 2834598
SGTC_1988 st071872 53.4 µM -0.329287200055184 0.386232759128079 no 2117 0.370969309012879 3114 16414116
SGTC_2073 5212005 126 µM -0.329989409647739 0.386107312203693 no 2118 0.370703982108587 2942 691789
SGTC_1644 st010134 20.9 µM -0.331680823287499 0.38580519685097 no 2119 0.370065141263269 3108 3818134
SGTC_1182 1222-0449 220 µM -0.332766915138886 0.385611238804228 no 2120 0.36965511707733 3057 658318
SGTC_2083 5306046 65.942 µM -0.333452386411021 0.385488839687213 no 2121 0.369396412438615 3004 539837
SGTC_2809 7964133 12.99 µM -0.334933646966033 0.385224381811154 no 2122 0.368837569966747 3027 1253665
SGTC_1085 doxorubicin 7.67 µM -0.339449603568754 0.384418452233016 no 2123 0.367135528056168 3104 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_665 3914-0008 307 µM -0.341404276623007 0.384069770740647 no 2124 0.366399628013412 2999 1069549
SGTC_2817 7995342 71.43 µM -0.341604003749218 0.38403414798743 no 2125 0.366324461863727 2942 18879975
SGTC_329 k048-0121 21.3 µM -0.345073747132367 0.383415451176239 no 2126 0.365019464695482 3080 6832902
SGTC_1000 4048-0884 8.67 µM -0.345885041812645 0.38327083042508 no 2127 0.364714555266306 3131 13040088
SGTC_2388 9080168 200 µM -0.346817972824817 0.383104546984105 no 2128 0.364364036934231 2991 15943073
SGTC_67 0335-0847 266 µM -0.346836182371724 0.383101301571259 no 2129 0.364357196419597 3316 4552207 YOR254C SEC63
SGTC_1446 4239-0190 62 µM -0.34729861693464 0.3830188865067 no 2130 0.364183494863739 3028 1340085
SGTC_2495 cafestol 54.53 µM -0.351224440400343 0.382319440088427 no 2131 0.362709987936108 3201 16667697 An anti-infammatory.
SGTC_3195 9113082 49.47 µM -0.353699475454432 0.381878671262011 no 2132 0.361782057874277 3122 17018038
SGTC_3185 9108267 49.47 µM -0.35625801940234 0.381423191591328 no 2133 0.360823672584838 3110 4910486
SGTC_2321 7390090 138.78 µM -0.357777023034193 0.381152851634013 no 2134 0.360255093439563 3079 649046
SGTC_1836 st055642 81 µM -0.359731057627446 0.380805173686494 no 2135 0.359524132054377 3054 8571
SGTC_2256 7954252 200 µM -0.365153298465677 0.379840908661379 no 2136 0.357498488600117 3120 2972920
SGTC_3347 9188721 44.724 µM -0.365572832048981 0.379766331885753 no 2137 0.357341925370112 3117 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_408 cantharidin 100 µM -0.367370622599621 0.379446805225662 no 2138 0.356671290852923 3072 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.368273757645849 0.379286319399342 no 2139 0.356334558991328 3023 803109
SGTC_425 3825-7017 13.1 µM -0.369108647638169 0.379137979124147 no 2140 0.356023371744543 3272 3397440
SGTC_244 nsc-207895 1.295 µM -0.370424028462448 0.378904303065288 no 2141 0.355533286504582 2994 42640
SGTC_383 2324-0395 7.37 µM -0.371365002058419 0.378737167214637 no 2142 0.35518284452946 3184 3146421
SGTC_1556 plumbagin 1.48 µM -0.372187361484662 0.378591118194953 no 2143 0.354876677673108 3114 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1280 0880-0253 10.1 µM -0.373905124037811 0.378286103729803 no 2144 0.354237452041522 3064 6836607
SGTC_2145 5634607 200 µM -0.37445498462986 0.378188483760189 no 2145 0.354032920770868 3057 308662
SGTC_2438 5259590 200 µM -0.375258812958087 0.378045789405364 no 2146 0.3537339970817 3155 1201127
SGTC_2257 7960413 200 µM -0.377068480280123 0.377724600986857 no 2147 0.353061357186451 3043 2974689 YIL048W NEO1
SGTC_1562 morin hydrate 59.1 µM -0.377405648181965 0.377664768148325 no 2148 0.352936085033681 3230 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1425 4048-4433 7.33 µM -0.385636999445158 0.376204970222299 no 2149 0.349882763629584 3167 23734946
SGTC_1873 rapamycin 2 nM -0.3860004306102 0.376140557760144 no 2150 0.349748174946766 3096 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.386035509829993 0.376134340702303 no 2151 0.349735185133485 3064 16623 A steroid.
SGTC_1098 clofazimine 15.1 µM -0.386342795592836 0.376079882103554 no 2152 0.34962140492737 3198 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1969 st069479 40.1 µM -0.386559199735592 0.376041531444968 no 2153 0.349541284009325 3234 3895485
SGTC_2019 4016004 108 µM -0.387863428184719 0.375810424927063 no 2154 0.349058551821217 3150 45595336
SGTC_2222 6885208 172.143 µM -0.391742643666858 0.375123299722929 no 2155 0.347624189077547 3133 609514
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.392172796847889 0.37504713107329 no 2156 0.347465271225766 3092 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_98 0074-0023 107.663 µM -0.394249222003894 0.374679520169898 no 2157 0.346698524229852 3166 3563821
SGTC_937 3122-0005 46.7 µM -0.394348576493803 0.374661933274338 no 2158 0.346661851998994 3243 759535
SGTC_532 1548-0774 215 µM -0.394925928848725 0.374559740380183 no 2159 0.346448776848712 3303 5932993
SGTC_622 1348-1566 26.3 µM -0.396293562174261 0.374317700828198 no 2160 0.345944237974855 3171 7340407
SGTC_2638 epoxomicin 18 µM -0.397293086645124 0.374140839370761 no 2161 0.345575672418148 3214 9915668 A protesome inhibitor.
SGTC_2707 st078556 66.6 µM -0.397834896823784 0.374044979511556 no 2162 0.345375945982402 3156 17250899
SGTC_3186 9110464 49.47 µM -0.399686871861147 0.373717377351167 no 2163 0.344693581353442 3225 17018021
SGTC_1811 st050069 61.5 µM -0.401164320878643 0.373456091771909 no 2164 0.344149573706262 3211 3877702
SGTC_2263 7948595 193.29 µM -0.402594575188527 0.373203207941649 no 2165 0.343623250546388 3075 2971371
SGTC_2023 5144124 124 µM -0.40379111100792 0.372991689918251 no 2166 0.34318316680674 3091 2830192
SGTC_2 0422-0095 29 µM -0.405582896345554 0.372675018058278 no 2167 0.342524549026532 3162 6790840
SGTC_2621 lithochol-11-enic acid 100 µM -0.406663433693645 0.372484090454743 no 2168 0.342127600286318 3242 6708711
SGTC_401 neomycin 50 µM -0.409530405370835 0.37197765740761 no 2169 0.341075229046698 3156 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_771 0250-0039 27.3 µM -0.41044324602137 0.371816456106496 no 2170 0.340740414036567 3127 3005115
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.410928633583156 0.371730749192633 no 2171 0.34056243288469 3242 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2105 5350118 200 µM -0.414566258884362 0.371088641075537 no 2172 0.339229726352368 3173 2133313
SGTC_1262 0737-0114 49.6 µM -0.414686022623392 0.371067506651512 no 2173 0.339185882916667 3296 765919
SGTC_2149 5554786 194.827 µM -0.41819472109114 0.370448507750738 no 2174 0.337902377536719 3147 745063 YPR165W RHO1
SGTC_535 2293-4129 48.2 µM -0.419132476390744 0.370283127192209 no 2175 0.337559658535674 3278 396118 YIL048W NEO1
SGTC_624 k048-0052 28 µM -0.42180795875411 0.369811416609565 no 2176 0.336582598025143 3172 6835531
SGTC_2737 bleomycin 30.5 nM -0.422078259825587 0.369763771082662 no 2177 0.336483947861838 3208 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2692 st077426 47.7 µM -0.431545940163412 0.368096184863747 no 2178 0.33303572820395 3296 25238571
SGTC_2679 rapamycin 1 nM -0.43158047500272 0.368090106608513 no 2179 0.333023175868809 3231 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2147 5545932 89.7195 µM -0.433705475146346 0.367716162569106 no 2180 0.332251165106403 3214 797404
SGTC_726 3448-4391 34.2 µM -0.439231612290152 0.366744295720376 no 2181 0.330246860670003 3370 1356692
SGTC_2619 obliquin 87.91 µM -0.44300848867502 0.366080557301716 no 2182 0.328879797382346 3156 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3176 9106582 49.47 µM -0.443242881610895 0.3660393788777 no 2183 0.328795032596209 3212 17018027
SGTC_760 0568-0725 82.9 µM -0.443341347531729 0.366022080730233 no 2184 0.328759426458734 3298 3916171
SGTC_3181 9108277 49.47 µM -0.44445976996465 0.365825619322919 no 2185 0.328355104292542 3169 17097298
SGTC_1650 st011916 45.8 µM -0.4445408067886 0.365811385809821 no 2186 0.328325816380242 3311 242528
SGTC_2945 9067681 61.76 µM -0.445334850003167 0.365671927822777 no 2187 0.328038893205434 3279 16456930
SGTC_1862 st057513 3.81 µM -0.445575827122871 0.365629608467807 no 2188 0.327951837498308 3147 5393163
SGTC_1611 st001856 99.4 µM -0.445666805678633 0.365613631634298 no 2189 0.327918972897492 3219 647478
SGTC_1380 2291-0730 164 µM -0.447524287030674 0.365287488515881 no 2190 0.327248278025072 3245 2999191
SGTC_2884 9058502 51.95 µM -0.45027656960115 0.364804412185944 no 2191 0.326255515695541 3283 6471554
SGTC_1973 st070275 50.2 µM -0.451994261157223 0.364503034334215 no 2192 0.325636558365153 3261 17118334
SGTC_2477 5967686 25.23 µM -0.455886640151202 0.363820406463652 no 2193 0.324235748511166 3145 776118
SGTC_643 k048-0106 28.4 µM -0.456352535330255 0.363738728774731 no 2194 0.324068245790881 3294 6763920
SGTC_1846 st056244 14.8 µM -0.459309475821005 0.363220481848342 no 2195 0.323005972017678 3249 5393182
SGTC_2645 abamectin 100 µM -0.462833078490765 0.362603246011982 no 2196 0.321742009489228 3287 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2275 7947463 200 µM -0.464006260417733 0.362397816735125 no 2197 0.321321630164066 3311 1225414
SGTC_2407 paclitaxel 400 µM -0.464373672147208 0.362333489480724 no 2198 0.321190024718478 3364 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_213 1246-0773 967 nM -0.465870244029497 0.362071506561256 no 2199 0.320654190652116 3260 6251622
SGTC_547 1120-0019 610 nM -0.466381447592969 0.361982032438099 no 2200 0.320471244349759 3239 3676939
SGTC_489 paxilline 115 µM -0.466589481930835 0.361945623094317 no 2201 0.320396806818062 3278 105008 A toxic potassium channel blocker.
SGTC_1087 pterostilbene 9.05 µM -0.467063486454285 0.361862669371684 no 2202 0.320227228505507 3336 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1186 1319-0216 26 µM -0.468986682035862 0.361526164872935 no 2203 0.31953957777244 3378 4565136
SGTC_2871 9038510 12.99 µM -0.474236360827092 0.360608166205858 no 2204 0.317665683521864 3394 4945164
SGTC_3094 9117742 49.47 µM -0.47728355472081 0.360075678604786 no 2205 0.316580109899987 3249 17149698
SGTC_1038 k292-0204 154 µM -0.479401493196065 0.359705735276567 no 2206 0.315826515709082 3218 4454212
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.480694456630736 0.359479956091106 no 2207 0.31536683576067 3409 688751
SGTC_1200 1643-0193 18.4 µM -0.482376562741475 0.359186297656532 no 2208 0.31476923370285 3362 5403974
SGTC_2783 7738165 71.43 µM -0.482418698787209 0.359178942704214 no 2209 0.314754270241832 3269 17201110
SGTC_1493 4348-0038 111 µM -0.483627848318595 0.358967904872027 no 2210 0.314325003627923 3352 800424
SGTC_1401 3807-4679 7.6 µM -0.485935383394663 0.358565280781239 no 2211 0.313506490155398 3326 3291456
SGTC_1275 0867-0008 21.1 µM -0.489231261087628 0.357990480981453 no 2212 0.31233898996066 3217 3422836
SGTC_2648 atorvastatin 78.68 µM -0.493214873177929 0.357296170150336 no 2213 0.3109303849192 3365 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1387 3342-1166 1.8 µM -0.496814876548839 0.356669125229733 no 2214 0.309659801757178 3310 3418228
SGTC_2045 5106652 78.05 µM -0.497253946829896 0.356592674870771 no 2215 0.309504991634447 3355 673349
SGTC_1931 st074438 57.1 µM -0.497646248603827 0.356524372658059 no 2216 0.309366700029208 3343 2787313
SGTC_999 SEC7.066 22.7 µM -0.501357682422888 0.355878416579616 no 2217 0.308059708170839 3263 740511 YDR170C SEC7
SGTC_2457 5731572 11.68 µM -0.501754796034366 0.355809325445305 no 2218 0.307920007153846 3379 2865357
SGTC_1428 4049-0204 61.7 µM -0.503222059337844 0.355554087234705 no 2219 0.307404078578459 3384 X1428
SGTC_12 0849-0099 9.267 µM -0.507284409228771 0.35484775815194 no 2220 0.305977638141127 3341 6071388
SGTC_2253 7938677 135.83 µM -0.507981828278346 0.354726546560976 no 2221 0.305733043525723 3420 2301972
SGTC_34 0469-0683 81.75 µM -0.511534170440369 0.354109377137443 no 2222 0.304488533848782 3359 3690923
SGTC_80 0159-0065 512.242 µM -0.51466070190971 0.353566503168732 no 2223 0.30339506955161 3371 1548079
SGTC_936 3005-4620 401 µM -0.520445561048528 0.352562837281717 no 2224 0.301376530849257 3454 777207
SGTC_2426 5582046 32.21 µM -0.520807247159974 0.352500119183609 no 2225 0.301250527022607 3444 2251934
SGTC_1812 st052057 4.327 µM -0.526567458958874 0.351501812442891 no 2226 0.299246997300172 3345 3645418
SGTC_2789 5281112 71.43 µM -0.532333288941284 0.350503556732785 no 2227 0.297247590107005 3345 765948
SGTC_1743 st037606 46.3785 µM -0.533626861944497 0.350279737933684 no 2228 0.296799859837089 3349 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2671 danthron 100 µM -0.534011231275893 0.350213242941114 no 2229 0.296666881801851 3385 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1793 st048256 72.231 µM -0.535412476893101 0.349970869630663 no 2230 0.29618233216703 3386 672022
SGTC_200 k038-0079 37.545 µM -0.537264336460499 0.349650647434015 no 2231 0.295542518168663 3335 3436683
SGTC_311 1315-0136 58 µM -0.537555788351676 0.349600259521273 no 2232 0.295441879996564 3463 6759207
SGTC_3053 9095903 49.47 µM -0.544551297766285 0.348391631662802 no 2233 0.293031079165317 3450 17174018
SGTC_2807 7945238 51.95 µM -0.545203687655363 0.348278995189183 no 2234 0.29280671777849 3417 17148797
SGTC_1137 ixabepilone 100 µM -0.545531960402429 0.348222323275016 no 2235 0.292693852685214 3450 154225 A novel microtubule stabilizer.
SGTC_423 5-fluorouracil 457 µM -0.547245740618757 0.347926517016583 no 2236 0.292104957711193 3325 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2070 5230947 200 µM -0.547351373548027 0.347908287318174 no 2237 0.292068677814997 3483 2835538
SGTC_2247 cerulenin 830 nM -0.547591725366652 0.347866809695478 no 2238 0.291986136192828 3518 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1006 4099-6547 255 µM -0.54984332352003 0.347478338845026 no 2239 0.291213420339291 3446 3146833
SGTC_1665 st014639 11.4 µM -0.55094885878268 0.34728765814868 no 2240 0.290834366443594 3492 981133 YIL048W NEO1
SGTC_1066 ketoconazole 628 nM -0.552103856855275 0.347088487476424 no 2241 0.290438599813086 3483 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_93 0109-0045 59.227 µM -0.552900116653167 0.346951203092894 no 2242 0.290165903781453 3493 88733
SGTC_1563 conessine 56.1 µM -0.559800170968568 0.345762396999523 no 2243 0.287807873511517 3495 441082 An anti-amoebic, histamine inhibitor.
SGTC_1946 st076057 65.1 µM -0.561728669927739 0.345430408225891 no 2244 0.287150448812765 3381 953009
SGTC_772 k072-0172 35.3 µM -0.56679698881475 0.344558470528964 no 2245 0.285426058322454 3388 5861980
SGTC_898 1000-0849 28.3 µM -0.568127087405765 0.344329781053642 no 2246 0.284974338023114 3448 6751807
SGTC_571 k831-0106 44.2 µM -0.572602963979865 0.34356064300558 no 2247 0.283456776193708 3474 4783639
SGTC_2462 5162487 171.77 µM -0.57366658349075 0.343377964877284 no 2248 0.283096722667574 3465 2259986
SGTC_264 promethazine 12.5 mM -0.573876126767013 0.343341979840857 no 2249 0.283025814546553 3543 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2171 5739187 198.077 µM -0.574191986065546 0.343287739751749 no 2250 0.282918945868619 3366 2262761
SGTC_2140 5586273 200 µM -0.57591669255132 0.342991626124262 no 2251 0.28233574609118 3473 854421
SGTC_1730 st033808 45.1 µM -0.581037680017434 0.342112976110165 no 2252 0.280607529340106 3377 1045166
SGTC_1008 4106-0037 6 µM -0.581150601326708 0.34209361087941 no 2253 0.280569478716842 3476 2905394
SGTC_1369 1866-0067 208 µM -0.587907553273541 0.340935597494676 no 2254 0.27829717314547 3526 3531355
SGTC_572 0960-0087 17.7 µM -0.589187415558304 0.34071642168243 no 2255 0.277867779059499 3445 6796365
SGTC_138 0850-0259 40.9225 µM -0.591366563571731 0.340343367347613 no 2256 0.2771374193719 3540 6813004
SGTC_2962 9082311 13.18 µM -0.5922405513834 0.340193790835786 no 2257 0.276844759188921 3442 16459453
SGTC_938 3126-1755 342 µM -0.594783750886209 0.339758684266427 no 2258 0.275994015266506 3527 1777771
SGTC_1980 st071811 45.7 µM -0.597844596447943 0.339235298580808 no 2259 0.274971815311292 3573 4974850
SGTC_2324 6149169 200 µM -0.599223213974588 0.338999664704764 no 2260 0.274512022268226 3418 2888231
SGTC_2452 5863136 48.41 µM -0.59965460689643 0.338925943780039 no 2261 0.274368223154136 3482 2184096
SGTC_2297 7971671 152.32 µM -0.601619604217962 0.33859022260593 no 2262 0.273713688154774 3552 909016
SGTC_3137 9097352 49.47 µM -0.601850835249959 0.338550725048548 no 2263 0.273636716581358 3637 44120435
SGTC_800 3448-7362 155 µM -0.605396809317743 0.337945244768175 no 2264 0.272457685281627 3583 15991913
SGTC_2212 7123476 200 µM -0.605563064151028 0.337916866783264 no 2265 0.272402467764584 3482 1085715
SGTC_2007 4011539 71.82 µM -0.607931544871255 0.337512691664846 no 2266 0.271616438396588 3532 45595301
SGTC_859 0439-0102 54.6 µM -0.608839366534062 0.337357823890641 no 2267 0.271315458652672 3566 610143
SGTC_3043 9092303 49.47 µM -0.610244276602688 0.337118210763406 no 2268 0.270850001814672 3482 25236084
SGTC_2252 omeprazole 400 µM -0.619286810260161 0.33557755454445 no 2269 0.267863715985227 3495 4594 A proton pump inhibitor.
SGTC_1832 st054113 55 µM -0.621175649300662 0.335256084018863 no 2270 0.267242029674982 3555 1251267
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.621630832098509 0.335178632313351 no 2271 0.267092321251414 3513 2724278 An inhibitor of dopamine biosynthesis.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.627664298531591 0.334152669889349 no 2272 0.26511193884323 3538 2374 Ca(2+)-ATPase inhibitor.
SGTC_3084 9116877 49.47 µM -0.629626665045138 0.333819245172949 no 2273 0.264469436651745 3505 27241325
SGTC_3133 9127736 49.47 µM -0.630118507946905 0.333735696938339 no 2274 0.264308525705465 3580 27243420
SGTC_3178 9107506 49.47 µM -0.630803894414754 0.333619285646094 no 2275 0.264084378353308 3598 8897194
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.636248227327187 0.332695148125561 no 2276 0.262307321882071 3587 5377381
SGTC_982 1491-0518 27.5 µM -0.637797829409993 0.332432299423076 no 2277 0.261802646359 3525 3091256
SGTC_856 0433-0016 11.3 µM -0.639665161128919 0.332115665810239 no 2278 0.261195154835607 3577 3911780
SGTC_1560 lithocholic acid 53.1 µM -0.640398832417747 0.331991293806252 no 2279 0.260956670872355 3537 9903 A bile acid which acts as a detergent.
SGTC_2305 7443522 69.23 µM -0.642505275327934 0.331634312362313 no 2280 0.260272582595797 3551 5415886
SGTC_3021 9087658 49.47 µM -0.644537182098596 0.331290107474779 no 2281 0.259613577341787 3591 25237042
SGTC_1559 coumarin 343 70.1 µM -0.646486483866851 0.330960029767978 no 2282 0.258982173834393 3626 108770 A hepatotoxic, DNA x-linker.
SGTC_940 3232-1287 54.8 µM -0.650319591300654 0.3303113481734 no 2283 0.25774290237146 3576 1585493 YIL048W NEO1
SGTC_884 0851-0618 334 µM -0.65165091946487 0.33008616497173 no 2284 0.257313195678944 3600 9642473
SGTC_377 3970-0964 33.1 µM -0.653259172756778 0.329814224241942 no 2285 0.256794604134452 3598 16481235
SGTC_2641 levomentholum 100 µM -0.653598209797379 0.329756907692696 no 2286 0.256685348948395 3562 16666
SGTC_2394 5221648 200 µM -0.653828010888436 0.329718060506881 no 2287 0.256611308972401 3647 788586
SGTC_1693 xanthone 101.9 µM -0.655712161692777 0.329399619766408 no 2288 0.256004671149233 3614 7020 An insecticide.
SGTC_309 k408-0051 1.48 µM -0.657083954019132 0.32916785064127 no 2289 0.255563467901632 3585 3640463
SGTC_3189 9110682 49.47 µM -0.660540640181749 0.328584122657086 no 2290 0.25445347376025 3641 17122418
SGTC_2655 perillic acid 100 µM -0.660849376207745 0.328532006954005 no 2291 0.254354456998678 3591 5702197 An apoptosis inducer.
SGTC_2279 7948423 32.93 µM -0.661911509065833 0.328352740755422 no 2292 0.254013967701935 3632 1247112
SGTC_630 4356-0227 183 µM -0.666955204531655 0.327502008519855 no 2293 0.252400373567264 3632 779312
SGTC_970 1315-0089 19.5 µM -0.667171799809077 0.32746549488412 no 2294 0.252331200945931 3577 6811083 YLR033W RSC58
SGTC_1516 st013856 110 µM -0.668092107759863 0.327310367761042 no 2295 0.252037399678538 3612 5281404 A mutagen and neurotoxin.
SGTC_1924 st058459 75.1 µM -0.670893796873085 0.326838298658868 no 2296 0.251144094159694 3597 688683
SGTC_2905 7799065 20.05 µM -0.671642117249209 0.326712257665335 no 2297 0.250905779400988 3571 1296806
SGTC_1897 st060201 15 µM -0.673019030972057 0.326480393197709 no 2298 0.250467591829572 3623 611878
SGTC_2308 7584454 197.62 µM -0.675193639309411 0.326114338018501 no 2299 0.249776373637781 3679 893577
SGTC_1400 3771-8998 51.5 µM -0.675218238165349 0.326110198212461 no 2300 0.249768560474807 3584 670767
SGTC_2242 6630449 61.2675 µM -0.675442718093883 0.326072420886147 no 2301 0.249697266477381 3623 691249 YDR170C SEC7
SGTC_3150 9097574 49.47 µM -0.675890058619549 0.32599714407095 no 2302 0.249555225010529 3618 17217476
SGTC_2647 atorvastatin 60.16 µM -0.678304511496985 0.32559097132608 no 2303 0.248789319385541 3620 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2095 5432005 200 µM -0.679449954101068 0.325398350939639 no 2304 0.248426403646381 3651 783734
SGTC_2882 9058044 58.44 µM -0.680801994419305 0.32517104858949 no 2305 0.247998393957555 3606 18076804
SGTC_591 4299-0174 154 µM -0.680868152614455 0.325159927872767 no 2306 0.247977460639848 3615 5509088
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.68349401459804 0.324718665205023 no 2307 0.247147365522364 3676 6708784 An antioxidant flavonoid
SGTC_2220 6782180 200 µM -0.687544803518657 0.324038433222719 no 2308 0.245869738674934 3593 833803
SGTC_1341 1486-1360 280 µM -0.687550720827023 0.324037439982865 no 2309 0.245867874940599 3656 3976547
SGTC_3001 9076041 71.4286 µM -0.688423064432286 0.323891027920075 no 2310 0.245593201787419 3666 16004211
SGTC_2899 9053889 58.44 µM -0.690752310595321 0.323500226355208 no 2311 0.244860604814855 3622 6470052
SGTC_231 b-estradiol 524 µM -0.692316429240036 0.323237907283437 no 2312 0.244369317411594 3607 450 A steroid.
SGTC_842 0271-0008 11.1 µM -0.693059649343436 0.323113292276533 no 2313 0.244136059366167 3716 1221709
SGTC_454 lyso-paf C-16 6.67 µM -0.695017193454447 0.322785167738556 no 2314 0.243522263332139 3611 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2718 lomofungin 53.02 µM -0.695353416125111 0.322728823795786 no 2315 0.243416923269242 3685 5351222 A RNA synthesis inhibitor.
SGTC_1079 idarubicin 2.36 µM -0.69826187825259 0.322241595877348 no 2316 0.242506717604836 3642 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2865 9030313 51.95 µM -0.699417839148386 0.322048033102924 no 2317 0.242145471272833 3614 42562754
SGTC_1587 estradiol valerate 56.1 µM -0.705461472129668 0.321036828567865 no 2318 0.240261550205377 3677 13791 A steroid.
SGTC_717 1532-0246 73.2 µM -0.706135571437245 0.320924122122935 no 2319 0.240051916212031 3686 9561992
SGTC_2020 4017018 200 µM -0.708771285794162 0.320483600709298 no 2320 0.23923320969808 3747 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_655 k060-0012 42 µM -0.713807625378201 0.31964255298438 no 2321 0.237673071906915 3679 5994525
SGTC_223 busulfan 5 mM -0.713948612815798 0.319619021984237 no 2322 0.237629477830753 3676 2478 A DNA alkylator.
SGTC_1473 k844-0725 134 µM -0.714821282815356 0.319473388303842 no 2323 0.237359741210754 3770 54682906
SGTC_946 3434-1334 87.4 µM -0.717655808426413 0.319000546680738 no 2324 0.236484768808269 3691 4047976
SGTC_1741 st038134 10.228 µM -0.718173139796274 0.31891427975101 no 2325 0.236325268718982 3750 1272587
SGTC_1198 1612-1005 86.7 µM -0.719952417449202 0.3186176534941 no 2326 0.23577714637841 3760 6998509
SGTC_1015 4130-4525 82 µM -0.720355427460777 0.318550483176379 no 2327 0.235653092989114 3724 1363237
SGTC_1174 0739-0097 51.1 µM -0.72105463139085 0.318433959896446 no 2328 0.235437951471636 3723 728447
SGTC_1377 2944-0135 198 µM -0.723536175630535 0.318020552229747 no 2329 0.234675268576818 3784 1894137
SGTC_920 mycophenolic acid 780.421 nM -0.724021129009736 0.317939788895842 no 2330 0.234526381751708 3740 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3040 9091894 49.47 µM -0.727518427301868 0.317357611190578 no 2331 0.233454215545165 3630 25236966
SGTC_774 k060-0086 136 µM -0.728704491280883 0.317160275535082 no 2332 0.23309122244946 3734 5911235
SGTC_516 3992-2719 87.3 µM -0.731791903684037 0.316646840067796 no 2333 0.232147795746435 3698 5350887 YDR037W KRS1
SGTC_2844 9010103 25.97 µM -0.733220422432102 0.316409397368994 no 2334 0.231712000666019 3730 2480525
SGTC_707 0865-0008 204 µM -0.736155859241126 0.31592171830406 no 2335 0.230817925796612 3725 723043
SGTC_1050 3232-1156 69.3 µM -0.73627404976384 0.315902089411014 no 2336 0.230781967740234 3713 700529
SGTC_584 0986-0246 15.4 µM -0.73797332731169 0.315619933517265 no 2337 0.230265328821763 3824 53315 YDR232W HEM1
SGTC_43 0570-0105 72.5 µM -0.740352079043355 0.315225135088115 no 2338 0.229543194071971 3763 1114046 YDL195W SEC31
SGTC_780 0109-0199 192 µM -0.744013722507748 0.314617829067028 no 2339 0.228434086650122 3760 610414
SGTC_2951 9072950 58.06 µM -0.744606330915558 0.314519588406247 no 2340 0.228254869791118 3758 16488155
SGTC_2745 rifampicin 24.3 µM -0.748361429701008 0.313897386021995 no 2341 0.227121090330229 3702 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1841 st054148 70 µM -0.75024871802585 0.313584870682886 no 2342 0.226552461055281 3773 675442
SGTC_1407 3909-7909 12.3 µM -0.753171493593246 0.3131011534159 no 2343 0.225673433495316 3746 4411780
SGTC_521 r062-0005 13.8 µM -0.757062125709899 0.312457755428753 no 2344 0.224506321707015 3687 2832033
SGTC_3106 9121286 49.47 µM -0.757327795637246 0.312413842124381 no 2345 0.224426751158972 3765 15943471
SGTC_3206 9114350 49.47 µM -0.757606387827495 0.312367795725425 no 2346 0.224343327471064 3697 17087243
SGTC_270 tamoxifen 5.46 µM -0.758717605268978 0.312184160143263 no 2347 0.22401075156405 3820 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2221 6807166 181.081 µM -0.761252788887426 0.311765379994123 no 2348 0.223253046698419 3711 674925
SGTC_824 1304-0008 100 µM -0.761694194343548 0.311692490268895 no 2349 0.223121270584109 3791 768245
SGTC_1736 st036774 51 µM -0.767933196214238 0.310663027756293 no 2350 0.221263437105565 3869 1272247
SGTC_2597 laccaic acid a 100 µM -0.768824477714712 0.310516083115499 no 2351 0.220998757846456 3800 5491415 A textile dye.
SGTC_1751 st044839 27.194 µM -0.77357225441048 0.309733832081091 no 2352 0.219591892500391 3749 5291326
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.773957125544147 0.309670457793723 no 2353 0.21947807297002 3769 15053
SGTC_1138 3761-0006 1.03 µM -0.778111916303811 0.308986675287731 no 2354 0.21825151915554 3761 12061087
SGTC_2143 5623677 140.463 µM -0.782154033334381 0.308322070866893 no 2355 0.217062027490844 3759 5375313
SGTC_549 1661-1316 519 µM -0.785707930659087 0.307738257941045 no 2356 0.216019307983708 3817 2857282
SGTC_1152 3909-8331 15.9 µM -0.787640008716966 0.307421071771052 no 2357 0.215453652698005 3783 16001939
SGTC_1505 k297-0037 20.6 µM -0.788050690054041 0.307353669416268 no 2358 0.215333528175171 3806 4089396
SGTC_2184 6075246 200 µM -0.790064632477088 0.307023228858882 no 2359 0.214745011717875 3863 2267320
SGTC_2066 5222451 176 µM -0.790842532944721 0.306895635631718 no 2360 0.214517943246846 3806 2281147
SGTC_2987 9018338 71.43 µM -0.792327279464857 0.306652168633642 no 2361 0.214084934709827 3871 5055682
SGTC_984 1492-0255 2.91 µM -0.792946237691887 0.306550697770176 no 2362 0.21390457328902 3786 1585198
SGTC_3097 9117246 49.47 µM -0.793628948883381 0.306438792561781 no 2363 0.213705737207557 3839 16423892
SGTC_1023 4482-3888 16 µM -0.795380571735349 0.306151761462169 no 2364 0.213196078911334 3808 3303168
SGTC_2511 berberine 10.47 µM -0.797704383039095 0.305771151843063 no 2365 0.21252102986769 3815 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1698 5-fluorocytosine 1.055 µM -0.799278961918729 0.305513375762703 no 2366 0.21206433746202 3840 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2685 mycophenolic acid 18.85 µM -0.800523826185387 0.305309645844954 no 2367 0.211703682360706 3820 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1769 st044406 64.4 µM -0.801677056843752 0.305120966143382 no 2368 0.21136989536934 3828 670903
SGTC_3319 9138450 16.7555 µM -0.801730321681282 0.305112252751003 no 2369 0.211354486034736 3778 2029690
SGTC_3217 9129673 49.47 µM -0.802585298890128 0.304972405398654 no 2370 0.211107234125614 3823 17248312
SGTC_2069 5228469 200 µM -0.808259996878178 0.304044926063398 no 2371 0.209470462929191 3830 2835210
SGTC_53 0973-0023 39.979 µM -0.812427100942509 0.303364651350196 no 2372 0.20827330038502 3764 674768
SGTC_2545 solidagenone 89.61 µM -0.814898588844689 0.302961505538643 no 2373 0.207565180501753 3659 6708572 An anti ulcer agent
SGTC_540 1187-0821 17.3 µM -0.817572290456458 0.30252564510815 no 2374 0.206800727625411 3815 847520
SGTC_2346 9031566 143.75 µM -0.820445111517468 0.302057638238966 no 2375 0.205981203774898 3842 4771086
SGTC_3144 9087057 49.47 µM -0.820953952813905 0.301974777588433 no 2376 0.20583624871316 3723 17249618
SGTC_2277 7947813 106.88 µM -0.824667706292361 0.301370332617957 no 2377 0.204780135345764 3968 1246798
SGTC_1647 st011722 22.4 µM -0.827306657798278 0.300941152137382 no 2378 0.204031635556326 3831 2854783
SGTC_2857 9024691 58.44 µM -0.828145888010453 0.300804723428527 no 2379 0.203793942271409 3957 16478292
SGTC_252 miconazole 1.30953 nM -0.828498498859347 0.300747409886944 no 2380 0.203694122360167 3810 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2792 7535235 81.82 µM -0.829520877264031 0.300581259858846 no 2381 0.203404864111544 3880 1281891
SGTC_2969 9091408 28.7 µM -0.831690789731068 0.300228757753123 no 2382 0.202791750357215 3833 4286311
SGTC_527 4476-4215 268 µM -0.832065560955682 0.300167895129254 no 2383 0.202685969815392 3871 4418754
SGTC_2810 7959871 45.46 µM -0.832834857986305 0.300042979233207 no 2384 0.202468936268793 3869 2974535
SGTC_698 k064-0052 127 µM -0.834188822365386 0.299823184135223 no 2385 0.202087294422052 3927 5088751
SGTC_335 4077-0256 27.6 µM -0.834765605721241 0.299729574458535 no 2386 0.201924847375425 3869 3121989
SGTC_478 N-arachidonylglycine 10 µM -0.844167352056137 0.298205578187044 no 2387 0.199287947738855 3816 5283389
SGTC_2351 9026858 72.31 µM -0.844317922526599 0.298181199878672 no 2388 0.199245886784174 3828 1409300
SGTC_761 k216-0224 480 µM -0.844421781651779 0.298164384960592 no 2389 0.199216877478657 3900 1340404
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.844597515865755 0.298135934362384 no 2390 0.199167798250242 3680 4000243
SGTC_1620 st003704 16.5 µM -0.845375859166929 0.298009938868303 no 2391 0.198950509330244 3821 2834414
SGTC_60 0986-0278 202 µM -0.847070188629564 0.297735750681653 no 2392 0.198478000198104 3827 3110598
SGTC_633 0437-0093 97.7 µM -0.847122808320865 0.29772723723985 no 2393 0.198463336636164 3847 2831118
SGTC_3216 9129716 49.47 µM -0.848019238410514 0.297582219144323 no 2394 0.198213628333793 3879 8056934
SGTC_2335 9018011 154.17 µM -0.851007608117812 0.29709901497349 no 2395 0.197382563256043 3940 6458208
SGTC_2153 5569715 200 µM -0.851167296090445 0.297073204341921 no 2396 0.19733821345241 3921 2054701
SGTC_1312 1218-2183 165 µM -0.856601181462468 0.296195528260982 no 2397 0.195832666278076 3897 6744073
SGTC_672 1441-0018 53.7 µM -0.860784181330579 0.295520705417542 no 2398 0.194678459453961 3900 251141
SGTC_1573 oleylamine 1.06 µM -0.862631073936542 0.295222980452246 no 2399 0.194170169913966 3921 5356789 An amine of the fatty acid oleic acid.
SGTC_1704 st028805 70.8 µM -0.866975518277409 0.294523187177205 no 2400 0.192977711865283 3960 2876101
SGTC_2601 securinine 100 µM -0.867321201989502 0.294467538119311 no 2401 0.192883021471522 3887 442872 A GABA receptor antagonist.
SGTC_64 000l-0018 272.079 µM -0.86865234982274 0.294253291839846 no 2402 0.192518655853534 3866 6811119
SGTC_275 trichlorophene 5.69 µM -0.869692097395958 0.294085996104351 no 2403 0.192234346043709 3952 62616
SGTC_2687 chenodiol 100 µM -0.870912412439632 0.293889703097068 no 2404 0.191900989445936 3998 5702181 A cholesterol synthesis inhibitor.
SGTC_3349 9149703 23.001 µM -0.870944090633961 0.293884608328128 no 2405 0.191892340546974 3919 4910494
SGTC_1524 corynanthine 62.1 µM -0.872184774802852 0.293685102604706 no 2406 0.191553792024808 4069 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_182 3448-4371 550.524 µM -0.874115809740579 0.293374711186939 no 2407 0.191027594276853 3872 3491403
SGTC_1052 3253-3998 198 µM -0.875461622603683 0.293158477337963 no 2408 0.190661391480342 3889 5450317
SGTC_1504 k297-0033 30 µM -0.876186579857794 0.2930420279624 no 2409 0.190464305471451 3860 4388117
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.878170842340403 0.292723407065198 no 2410 0.189925506377912 3836 17037758
SGTC_1766 st045414 44.774 µM -0.880033027562469 0.292424535023985 no 2411 0.189420708929968 3981 253960
SGTC_1651 st011928 86.1 µM -0.883582177180302 0.291855306260831 no 2412 0.188460901821338 3967 720198
SGTC_1745 st081495 74 µM -0.887635225385841 0.291205891950594 no 2413 0.187368499566608 3868 13842402 YBL026W LSM2
SGTC_2886 9058944 51.95 µM -0.890224003159364 0.290791449058764 no 2414 0.186672809245875 3814 4949929
SGTC_2575 plumbagin 510 nM -0.890623027346723 0.290727592972713 no 2415 0.186565720650914 3862 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_740 k014-0057 261 µM -0.891899502338067 0.290523361950277 no 2416 0.186223400717828 3953 4012779
SGTC_2513 baicalein 25.65 µM -0.892003335799359 0.290506751954547 no 2417 0.186195572206524 3967 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2764 methyldopa 94.69 µM -0.893073813197739 0.290335536106786 no 2418 0.185908822739232 3948 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1306 1185-0270 9.02 µM -0.893285607775664 0.290301666551745 no 2419 0.185852121656766 3985 1548076
SGTC_1254 0550-0035 264 µM -0.893395268443171 0.290284130673117 no 2420 0.185822767808486 4053 15121435
SGTC_1203 3992-3522 103 µM -0.893691579020099 0.290236750018809 no 2421 0.185743466098522 4095 5322312
SGTC_752 1896-0090 130 µM -0.895906222210923 0.289882738917325 no 2422 0.185151425345767 3933 772567
SGTC_2686 alizarin 95.37 µM -0.897534689246048 0.289622557455303 no 2423 0.184716835788428 3983 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3071 9117417 49.47 µM -0.898106531533302 0.289531219775684 no 2424 0.184564378608126 3903 45595590 YGL055W OLE1
SGTC_3155 9099265 49.47 µM -0.901518289439229 0.288986557025073 no 2425 0.183656406972489 4001 25236499
SGTC_1908 st060353 56.5 µM -0.903627946303283 0.288650006765076 no 2426 0.183096358742252 4036 4227716
SGTC_2201 6605497 169.863 µM -0.904320242204868 0.288539606126248 no 2427 0.182912808147673 3897 670741
SGTC_1926 methyl fluorone black 53.6 µM -0.904872045334252 0.288451624164306 no 2428 0.18276658911726 3737 72721 Reacts with homocysteine.
SGTC_2628 lathosterol 100 µM -0.905980163532981 0.288274979039253 no 2429 0.182473175938686 4077 6710616
SGTC_1480 1070-0044 41.2 µM -0.906223939379959 0.288236125578027 no 2430 0.182408667235638 3984 3124987
SGTC_2999 9069765 71.4286 µM -0.906535250714046 0.288186511773049 no 2431 0.182326307805203 3981 2097066
SGTC_212 3807-4682 38.772 µM -0.908086895840776 0.287939285604696 no 2432 0.181916156644515 4049 3125501 YBL034C STU1
SGTC_351 caspofungin 25 nM -0.908955775733972 0.287800889294397 no 2433 0.18168673516 3989 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2693 st077581 40.7 µM -0.91021447750375 0.28760045740142 no 2434 0.181354705257893 4033 25238761
SGTC_3266 9136860 49.47 µM -0.91042787651206 0.287566482926248 no 2435 0.181298450938037 3857 4871271 YPR165W RHO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.911567836814463 0.287385026165097 no 2436 0.180998130020361 4015 5024745
SGTC_475 α-linolenic acid 10 µM -0.911579979705082 0.287383093573932 no 2437 0.180994932671979 3994 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_492 tmb-8 126 µM -0.912064163700651 0.28730603870269 no 2438 0.180867470872148 3913 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_395 anisomycin 6.25 µM -0.917036414400826 0.286515302165902 no 2439 0.179561779382658 4011 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2589 lobaric acid 100 µM -0.919064467742981 0.286193077762512 no 2440 0.179030926566265 4009 73157 A novel microtubule depolymerizer.
SGTC_612 0302-0167 22.4 µM -0.920494560528747 0.285965963006494 no 2441 0.178657187121581 4009 235821
SGTC_997 3996-0078 137 µM -0.922504303758514 0.285646938130697 no 2442 0.178132793239034 4038 735687
SGTC_2555 cholic acid 100 µM -0.922898732397765 0.285584346759993 no 2443 0.178029990637965 3989 6708657 Influences liver metabolism.
SGTC_2017 5132927 60.65 µM -0.923415797379011 0.285502304275294 no 2444 0.177895281172324 4019 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1845 st056753 3.01 µM -0.924480342079897 0.285333428751215 no 2445 0.177618140860745 3946 5375839
SGTC_1414 3917-0015 5.4 µM -0.92451160266154 0.285328470404727 no 2446 0.177610006696524 3950 6618702
SGTC_664 1222-0054 14.9 µM -0.925540570490761 0.285165285254067 no 2447 0.177342395196708 3967 6813991
SGTC_1456 k015-0012 13 µM -0.928761741341111 0.284654723970098 no 2448 0.1765062878887 3993 2989616
SGTC_1915 st067105 30.6 µM -0.92947195127875 0.2845422131825 no 2449 0.176322277352115 3964 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1291 0993-0025 5.79 µM -0.931121993390611 0.284280897093663 no 2450 0.175895231533051 4008 4353356
SGTC_3074 9116018 49.47 µM -0.934687908891143 0.283716557555114 no 2451 0.174974579936539 4065 17027303
SGTC_3281 9140613 49.47 µM -0.934797042174798 0.283699294655099 no 2452 0.174946452101973 4029 16013766
SGTC_1070 indatraline 8.81 µM -0.939099600580307 0.283019109385723 no 2453 0.173839804664952 4018 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_304 1310-0298 97 µM -0.946408664087047 0.281865427694239 no 2454 0.171970093995791 3870 1550234
SGTC_1398 3558-0053 112 µM -0.946681403484262 0.281822421688681 no 2455 0.171900574692007 3925 4532369
SGTC_2989 9073649 71.4286 µM -0.948219329611209 0.281579978124454 no 2456 0.171508904368221 3928 21367202
SGTC_2942 9052777 62.25 µM -0.948604051239158 0.281519345116973 no 2457 0.171411014884285 4081 6469503
SGTC_3008 9078912 71.4286 µM -0.951893226777609 0.281001220806852 no 2458 0.170575567474687 4011 16648731
SGTC_2566 crystal violet carbinol 226 nM -0.951894621957569 0.281001001130235 no 2459 0.170575213654395 4095 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1621 st003705 32.4 µM -0.953440698467983 0.280757616265985 no 2460 0.170183414503085 4048 24207032
SGTC_2617 dihydrotanshinone i 20.83 µM -0.953755027137024 0.280708146814877 no 2461 0.170103829459572 4019 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2285 7945142 200 µM -0.95420056454956 0.280638034786563 no 2462 0.169991064474967 4089 2970608
SGTC_1878 temozolomide 1 mM -0.9558371521745 0.280380565794392 no 2463 0.169577257515464 3929 5394 DNA alkylating agent.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.958981706370215 0.279886183797019 no 2464 0.168783980541911 3999 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1009 4106-0057 9.87 µM -0.96003214396089 0.279721129858825 no 2465 0.168519518745783 4027 2928005
SGTC_1451 4152-0210 104 µM -0.961127378878703 0.279549087284078 no 2466 0.168244062477559 4067 659563
SGTC_2061 5245884 80.95 µM -0.972306690618264 0.277795954224358 no 2467 0.165448998161779 4022 573863
SGTC_2862 9027634 71.43 µM -0.972482678877411 0.277768398825908 no 2468 0.165405238910919 3995 5012562
SGTC_1327 1436-0082 2.18 µM -0.976136422861245 0.277196614801347 no 2469 0.164498431983537 4049 15992205
SGTC_1622 st003707 19.4 µM -0.977491701989615 0.276984670100451 no 2470 0.164162891935365 4088 10140899
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.980394630763382 0.276530964047108 no 2471 0.163445679544 4080 688669
SGTC_3009 9080819 71.4286 µM -0.981062378050154 0.276426651708369 no 2472 0.163280990839074 4089 17027216
SGTC_1139 k015-0024 46.9 µM -0.982550700170301 0.276194222492571 no 2473 0.162914309166711 4098 2766652
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.986628951357996 0.275557819555449 no 2474 0.16191228597365 4143 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2482 5981709 142.65 µM -0.989180377566975 0.27516004164312 no 2475 0.161287448591899 4032 877755
SGTC_2467 5474540 200 µM -0.989200185099089 0.275156954673198 no 2476 0.161282603941742 4028 5413519
SGTC_81 0411-0046 9.971 µM -0.989362144599699 0.275131714202494 no 2477 0.161242994434831 4022 12925265
SGTC_617 3770-0098 35 µM -0.990249954105937 0.274993374379145 no 2478 0.161025980697234 4002 5962639
SGTC_1378 2093-0007 380 nM -0.992924230332128 0.274576871800352 no 2479 0.16037344030953 4160 3618014
SGTC_1051 3253-3903 78 µM -0.993269789673991 0.274523075705412 no 2480 0.160289247879209 4061 5509239
SGTC_2493 resveratrol 26.09 µM -0.994154600590419 0.274385353545457 no 2481 0.160073803349981 3966 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_544 k015-0020 52.4 µM -0.997211286484737 0.273909838333802 no 2482 0.159330981853856 4091 3008304
SGTC_2130 NSC 7 2.4545 µM -0.99762978048804 0.273844766777846 no 2483 0.15922945735197 4153 21448
SGTC_977 1348-1378 135 µM -0.998031557152009 0.273782301790491 no 2484 0.159132028263376 4074 X977
SGTC_2021 4019055 173 µM -0.999590261589629 0.273540033744043 no 2485 0.158754418943173 3957 44827708 YER133W GLC7
SGTC_1212 0520-0165 585 µM -1.00353170169532 0.272927892975034 no 2486 0.157802194550685 4256 5403258
SGTC_341 1486-1430 230 µM -1.00368758472821 0.272903696922344 no 2487 0.157764611572289 4065 2054753 YPL210C SRP72
SGTC_3297 9117502 71.43 µM -1.00672507331027 0.272432432547903 no 2488 0.157033454786856 4113 7453720
SGTC_2124 5246320 200 µM -1.00780679999913 0.272264701008891 no 2489 0.15677361039387 4110 579342
SGTC_2393 9031399 185.94 µM -1.01041811332219 0.27186000475889 no 2490 0.156147506664292 4158 1526623 YDL150W RPC53
SGTC_3111 9122088 49.47 µM -1.012417435083 0.271550356195753 no 2491 0.155669252748485 3942 16876704
SGTC_2404 5161160 200 µM -1.01313259254318 0.271439637560992 no 2492 0.155498416139704 4061 2831543
SGTC_586 0957-0265 8.15 µM -1.01443370688176 0.271238260452321 no 2493 0.155187923656863 3990 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_327 1273-0057 3.96 µM -1.01462641993277 0.271208440047451 no 2494 0.15514197024295 3973 3108138
SGTC_2313 7726885 200 µM -1.01710910711411 0.270824415421396 no 2495 0.154550764187666 4147 726423
SGTC_174 3553-0389 74.3 µM -1.01743891902473 0.270773420203837 no 2496 0.154472337773793 4189 738071
SGTC_469 w7 172 µM -1.01954521499709 0.270447859741237 no 2497 0.153972099441762 4181 45115570 A P450 inhibitor.
SGTC_2829 7992743 58.44 µM -1.01991763655068 0.270390316615114 no 2498 0.153883762198654 4131 16462845
SGTC_2087 5276107 200 µM -1.02158190211217 0.270133244526574 no 2499 0.153489413465745 4078 144405
SGTC_1463 k081-0032 34.1 µM -1.02559919479451 0.269513214407916 no 2500 0.152540273584722 3790 977755
SGTC_246 cycloheximide 667 µM -1.02581848610292 0.26947938946397 no 2501 0.152488575373822 3999 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3200 9114385 49.47 µM -1.02694519859919 0.269305631423417 no 2502 0.152223134796179 4162 17018030 YLR208W SEC13
SGTC_61 0978-8327 98.565 µM -1.03046942824627 0.268762498837349 no 2503 0.151394848154468 4037 6150059 YHR072W ERG7
SGTC_366 0181-0206 4.31 µM -1.03439142729848 0.268158712063061 no 2504 0.150476605229243 4148 274874
SGTC_121 0557-0495 61.343 µM -1.03535094388575 0.268011099701917 no 2505 0.150252523267216 4229 3104427
SGTC_3338 9144300 39.5675 µM -1.03882630586019 0.267476791486639 no 2506 0.149442762370559 4134 4901274
SGTC_3157 9099274 49.47 µM -1.03911740060876 0.267432062465316 no 2507 0.149375069624773 4169 17217662
SGTC_529 4076-0302 30.3 µM -1.03980432537094 0.267326525974427 no 2508 0.149215409586285 4082 5816522
SGTC_906 1165-0455 526 µM -1.04062467026667 0.267200518861573 no 2509 0.149024888433864 4109 3252859
SGTC_2287 7945887 168.79 µM -1.04098229867373 0.26714559559127 no 2510 0.148941881844146 4150 1245853
SGTC_1106 tegaserod maleate 11.7 µM -1.0434296773658 0.266769889082999 no 2511 0.148374667288748 4150 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_745 0469-0705 296 µM -1.04542937095333 0.266463106792456 no 2512 0.147912283985398 4207 3486736
SGTC_2451 5856223 45.7 µM -1.04549875689646 0.266452465176807 no 2513 0.147896257411539 4108 2179896
SGTC_3136 9095672 49.47 µM -1.046968538387 0.266227097566733 no 2514 0.147557044463521 3847 17217380
SGTC_694 1315-0438 43.2 µM -1.04864103153617 0.265970764774778 no 2515 0.147171681851532 4124 6793154
SGTC_2035 5154463 94.595 µM -1.04884730974486 0.265939158439559 no 2516 0.147124199642959 4164 2769623
SGTC_2435 5706476 10.6 µM -1.05488372125881 0.265015091540282 no 2517 0.145739254110395 4126 5725375
SGTC_347 4534-1311 26.2 µM -1.05496762839937 0.265002258359137 no 2518 0.145720065093186 4144 2862016
SGTC_1800 st050079 29.0735 µM -1.05503424470803 0.264992069949861 no 2519 0.145704831586317 4013 3645560
SGTC_631 k072-0230 41.5 µM -1.05681353638878 0.264720015786215 no 2520 0.145298347620968 4168 5773147
SGTC_3003 9075612 71.4286 µM -1.05870050769322 0.264431652645261 no 2521 0.144868098296986 4177 6501993
SGTC_374 0880-0231 82.3 µM -1.06026999670284 0.264191928354021 no 2522 0.144510892401587 4054 6833587
SGTC_1602 st001878 87.6 µM -1.06134661920431 0.264027548693772 no 2523 0.144266203296443 4158 595405 YLR310C CDC25
SGTC_551 k048-0028 34.9 µM -1.06161842561918 0.263986057295145 no 2524 0.14420447274328 4152 6836383
SGTC_3212 9128307 49.47 µM -1.06238253144433 0.263869433925033 no 2525 0.144031030395299 4102 27243542
SGTC_557 1315-0110 16.2 µM -1.06395524239453 0.263629478075122 no 2526 0.143674487852165 4166 6833801
SGTC_2754 granisetron 64.02 µM -1.06534884634252 0.263416942485995 no 2527 0.143359048029038 4168 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1880 MG-132 525 µM -1.06542959128116 0.263404630927669 no 2528 0.143340785896538 4119 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2479 5617353 43.85 µM -1.06674850713496 0.263203571257982 no 2529 0.143042708282762 4204 2731746
SGTC_1876 myriocin 605 nM -1.0679846097542 0.263015207091338 no 2530 0.142763727067579 4158 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_198 3454-2873 16.191 µM -1.07140151239756 0.26249487924032 no 2531 0.141994466559422 4145 710957
SGTC_1484 3473-2379 286 µM -1.07211480013593 0.262386325903168 no 2532 0.141834236028532 4285 671917
SGTC_331 k048-0133 24.5 µM -1.07238247512453 0.262345595101309 no 2533 0.141774138037598 4130 6813582
SGTC_705 1124-0212 310 µM -1.07590034733646 0.261810598670939 no 2534 0.140985913290694 4151 9554485
SGTC_2625 euphol 100 µM -1.08102227718934 0.261032659663485 no 2535 0.139843602138711 4205 6708538 A triterpene alcohol.
SGTC_2398 5228213 48.84 µM -1.08482846440422 0.260455331533112 no 2536 0.138998818008298 4191 80771 YMR134W ERG29
SGTC_2843 9000894 45.46 µM -1.0861739051092 0.260251410510931 no 2537 0.138701029965024 4111 2242070
SGTC_2691 st077356 60.2 µM -1.0871598501801 0.260102028510131 no 2538 0.138483085634271 4230 2839272
SGTC_2682 pyrogallin 40.03 µM -1.08923263527699 0.259788121977244 no 2539 0.138025655387144 4179 822798 An ATP competetive kinase inhibitor.
SGTC_3315 9136395 68.55 µM -1.0913009744954 0.25947508370527 no 2540 0.137570234552951 4186 16876844
SGTC_2293 7624732 200 µM -1.10198871870753 0.257860628589215 no 2541 0.135233288069389 4086 894453
SGTC_1206 3978-0017 132 µM -1.10565545830012 0.257307946448615 no 2542 0.13443783795232 4285 3873677
SGTC_1968 st069590 43.6 µM -1.1059221265899 0.257267775968153 no 2543 0.134380113401931 4183 6384066
SGTC_2955 9076254 12.21 µM -1.10608605073218 0.257243084318051 no 2544 0.134344637887693 4109 16459619
SGTC_26 0302-0163 425.158 µM -1.10678565879555 0.257137717244503 no 2545 0.134193305056724 4255 3100915
SGTC_1419 3993-2473 62.6 µM -1.11078273395862 0.256536153543822 no 2546 0.133330940081794 4266 704026
SGTC_2516 gossypol 71.55 µM -1.11168361933975 0.256400670720792 no 2547 0.133137102631094 4230 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2724 maprotiline 69.64 µM -1.1118128729286 0.256381235523271 no 2548 0.133109307922471 4129 4011 A tricyclic antidepressant.
SGTC_2170 morpholine 200 µM -1.11490804085103 0.255916060450095 no 2549 0.132444915316612 4243 121171 Reacts with secondary amines.
SGTC_2155 5570423 76 µM -1.11559765223174 0.25581247827447 no 2550 0.132297198766079 4165 797402
SGTC_468 gf-109203x 121 µM -1.11625916901192 0.25571313658035 no 2551 0.132155606903415 4200 2396 A protein kinase C inhibitor.
SGTC_3124 9127567 49.47 µM -1.11799284557221 0.255452881466104 no 2552 0.131785024492502 4193 17592030
SGTC_1146 3579-1023 7 µM -1.11927308309619 0.255260784343004 no 2553 0.131511827659657 4240 X1146
SGTC_1755 st041960 45.185 µM -1.11974046339408 0.255190673671229 no 2554 0.131412188323289 4251 2257073
SGTC_2338 7999974 200 µM -1.12007374332733 0.255140685245866 no 2555 0.131341169263757 4215 315925
SGTC_2892 9047358 58.44 µM -1.12031968913608 0.25510379928936 no 2556 0.131288777345486 4223 6466771
SGTC_488 nitrendipine 139 µM -1.12099947702931 0.255001861964317 no 2557 0.131144042509791 4248 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1246 0422-0085 105 µM -1.12129356892493 0.254957768135435 no 2558 0.131081461054469 4238 264295
SGTC_866 0495-0101 262 µM -1.12143153022688 0.254937084676287 no 2559 0.131052110609458 4188 635694
SGTC_623 k072-0108 16.9 µM -1.12206707158759 0.25484181427038 no 2560 0.130916961606372 4182 5382803
SGTC_1113 artemisinin 1.17947 µM -1.12229568126604 0.254807549246144 no 2561 0.130868370912184 4248 2240 An anti-malaria and mitochondrial poison.
SGTC_66 0109-0187 42.4 µM -1.12525147489609 0.254364739166613 no 2562 0.130241243016117 4098 759417
SGTC_2946 9065502 71.43 µM -1.12563595534153 0.254307169467737 no 2563 0.130159821251078 4037 16489101
SGTC_1330 1469-0054 61.8 µM -1.12629633596797 0.25420830414393 no 2564 0.130020054081099 4216 7102664
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.12645732957327 0.254184204910639 no 2565 0.129985996122842 4235 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2994 9053520 71.4286 µM -1.12714754263959 0.254080900066233 no 2566 0.129840052566168 4267 4647384
SGTC_1627 st003713 25.6 µM -1.12949173677808 0.253730206798007 no 2567 0.129345226709725 4239 16195070 YER133W GLC7
SGTC_2136 5328288 199.296 µM -1.13195802046262 0.253361523390478 no 2568 0.128826041915895 4211 262395
SGTC_1567 st069303 68.4 µM -1.13400403945088 0.2530558789656 no 2569 0.128396426796675 4267 5581319
SGTC_3283 9109332 35.8195 µM -1.13477705792504 0.25294045215661 no 2570 0.128234370552205 4072 17027281
SGTC_364 0083-0097 67.7 µM -1.1349610393363 0.252912984208599 no 2571 0.128195821469098 4282 5207356
SGTC_1147 3809-1045 12.3 µM -1.13521547269818 0.252875000553821 no 2572 0.128142524058122 4230 325925
SGTC_1814 st052110 31.539 µM -1.13608719878866 0.252744885741083 no 2573 0.127960035996352 4173 674163
SGTC_1643 st009866 20.2 µM -1.13612209037787 0.252739678517247 no 2574 0.127952735514244 4173 3156273 YOR207C RET1
SGTC_2525 harmine 47.85 µM -1.13742708156889 0.252544962092728 no 2575 0.12767989570942 4212 5280953 A monoamine oxidase inhibitor
SGTC_1426 4048-4480 71.7 µM -1.13750331671021 0.252533589567811 no 2576 0.127663969431317 4234 14224343
SGTC_1086 cerivastatin 2.18 µM -1.13798010118133 0.252462470441729 no 2577 0.12756439574683 4204 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_964 1287-0107 19.4 µM -1.14016518097432 0.252136670059776 no 2578 0.127108745318701 4260 51516812 YPR165W RHO1
SGTC_105 0111-0055 734.78 µM -1.14252961840147 0.251784377023966 no 2579 0.126616970959302 4246 5179370
SGTC_1175 0741-0056 27.6 µM -1.14392056331958 0.251577252500658 no 2580 0.126328291111863 4322 765927
SGTC_2515 chrysin 20.77 µM -1.14478325967514 0.251448834301044 no 2581 0.126149475779715 4257 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_728 3030-5151 22.5 µM -1.14584754608028 0.251290455800473 no 2582 0.125929119077528 4315 3125388
SGTC_897 1000-0139 31.4 µM -1.14878003428952 0.25085433963109 no 2583 0.125323347080124 4202 6151020
SGTC_2634 4'-methoxyflavone 100 µM -1.14906607737905 0.25081182109956 no 2584 0.125264367467471 4249 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_392 N-ethylmaleimide 8.33 µM -1.15453469511118 0.249999679274407 no 2585 0.124140511395251 4180 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2775 cyproheptadine 69.59 µM -1.15489420848385 0.249946337041198 no 2586 0.124066875684357 4242 2913 A selective serotonin reuptake inhibitor.
SGTC_1500 4488-1866 171 µM -1.15678348354096 0.249666118120843 no 2587 0.123680415725011 4309 2900003
SGTC_209 4077-0173 175.592 µM -1.16171820238474 0.248934984135382 no 2588 0.122674974719593 4228 15993494
SGTC_1290 0986-0249 10.2 µM -1.16174930464966 0.248930379602109 no 2589 0.12266865591873 4103 53329
SGTC_139 0099-0334 718.624 µM -1.16221691777993 0.248861157303497 no 2590 0.122573682181426 4283 97690
SGTC_2924 9010168 62.78 µM -1.16359376243187 0.248657398010393 no 2591 0.122294340204313 4304 2993929
SGTC_3076 9116187 49.47 µM -1.16606032047881 0.248292594281912 no 2592 0.121795029031841 4243 27241210
SGTC_1861 st057647 17.4 µM -1.16693177012777 0.24816377520125 no 2593 0.121618962304731 4341 688668
SGTC_675 1309-0189 238 µM -1.16706987681836 0.248143363322054 no 2594 0.121591075809972 4281 4246530
SGTC_305 1682-2595 20.8 µM -1.16976018775559 0.247745919697616 no 2595 0.121048744661965 4275 226033
SGTC_2937 9044753 11.33 µM -1.17153997923718 0.247483175394869 no 2596 0.12069089885102 4195 6465530 YGL099W LSG1
SGTC_1790 st045711 43.5 µM -1.17441342854193 0.247059292713236 no 2597 0.120114734554158 4267 585119
SGTC_1449 4112-4002 201 µM -1.17457572275347 0.247035363147972 no 2598 0.120082250363757 4313 2059539
SGTC_2497 7-hydroxyflavone 100 µM -1.17569371311789 0.24687055410062 no 2599 0.119858645896678 4277 5281894
SGTC_1701 st028638 40.4 µM -1.17822721815685 0.24649729422502 no 2600 0.119353017191939 4278 3490878
SGTC_3327 9140648 26.9345 µM -1.17961238637748 0.246293346096425 no 2601 0.119077207138102 4296 8029710
SGTC_360 0957-0399 1.01 µM -1.18072055311348 0.246130248017161 no 2602 0.118856876927466 4282 6752301 YPR165W RHO1
SGTC_2919 7978188 46.38 µM -1.18203811897609 0.245936406338663 no 2603 0.118595288024883 4287 2980291
SGTC_1309 pyrazolanthrone 13.4 µM -1.18316936826519 0.245770041136748 no 2604 0.11837101513979 4247 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3168 9103419 49.47 µM -1.18425116526321 0.245611005081004 no 2605 0.118156826887273 4285 16649256
SGTC_3312 9133330 71.43 µM -1.18496536210345 0.245506040590037 no 2606 0.118015571188132 4306 17617324
SGTC_604 1000-0114 314 µM -1.18605069409963 0.245346577044826 no 2607 0.11780114017902 4285 1572745
SGTC_968 1309-0633 340 µM -1.1870122520556 0.245205345653408 no 2608 0.117611393890918 4311 3761976
SGTC_2703 st077852 53.4 µM -1.18782464206827 0.245086057777768 no 2609 0.117451251921628 4300 6281836
SGTC_1365 1672-3266 55.4 µM -1.1880927373809 0.245046698659473 no 2610 0.117398437668219 4291 6415873
SGTC_2349 9023730 187.07 µM -1.18856595388687 0.244977233962286 no 2611 0.117305255985327 4302 4126287
SGTC_2307 7538926 6.34 µM -1.18952842380381 0.244835983161868 no 2612 0.11711589641717 4228 96582
SGTC_1872 amphotericin b 148 nM -1.19107660249544 0.244608866520493 no 2613 0.116811757076648 4290 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2266 7929956 200 µM -1.19123061405775 0.244586279347716 no 2614 0.116781532188753 4216 2967153
SGTC_1979 st071809 45.3 µM -1.19165087145756 0.24452465055745 no 2615 0.116699084556734 4339 4976333
SGTC_1210 3013-0140 750 nM -1.19246042220874 0.244405957291468 no 2616 0.116540380274345 4296 905973
SGTC_3234 9132280 49.47 µM -1.19423925706972 0.244145260352939 no 2617 0.116192195444403 4306 17612295
SGTC_1942 st076330 65.2 µM -1.19475254473066 0.244070063425124 no 2618 0.116091863144764 4342 24208414
SGTC_2760 etidronate 98.04 µM -1.19518178060404 0.244007189723147 no 2619 0.116008007668248 4224 3305 A chelator and antioxidant.
SGTC_2861 9024595 19.48 µM -1.19520653495684 0.244003564016371 no 2620 0.116003172972142 4189 16482810
SGTC_1148 3909-7663 27.7 µM -1.19667472705979 0.243788573660248 no 2621 0.115716680697864 4334 4084526
SGTC_1397 3532-0190 20.1 µM -1.19805124109197 0.243587100815628 no 2622 0.11544853460306 4230 5322280
SGTC_3058 9093861 49.47 µM -1.19931007921485 0.243402930298994 no 2623 0.115203698680352 4303 17217477
SGTC_1981 st071826 47 µM -1.2034959600754 0.242791069037089 no 2624 0.114392226890105 4328 11838600
SGTC_1188 1403-0014 4.57 µM -1.20569471553769 0.242470004927658 no 2625 0.113967611678634 4272 9614867
SGTC_1368 1852-0141 284 µM -1.20605019695997 0.242418118839009 no 2626 0.113899068062899 4296 2838987
SGTC_1754 st042065 16.137 µM -1.20861689893783 0.242043661448842 no 2627 0.113405030515537 4063 1126236 YIL048W NEO1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.20892110252454 0.241999301841801 no 2628 0.113346579013208 4307 77254
SGTC_2202 7226349 200 µM -1.21051039928127 0.241767618956938 no 2629 0.113041551395435 4265 844334
SGTC_695 3505-6186 243 µM -1.21065997978009 0.24174581976287 no 2630 0.113012873176336 4287 1819379
SGTC_2420 aureobasidin a 50 nM -1.21080180725702 0.241725151444914 no 2631 0.112985686196215 4393 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_31 0508-1974 57.237 µM -1.21288115334054 0.241422241414847 no 2632 0.11258763110937 4217 6810525
SGTC_477 mead ethanolamide 10 µM -1.21432565597453 0.241211934033458 no 2633 0.112311696134581 4227 16061185
SGTC_224 benfluorex 43.875 µM -1.2149573833721 0.241119991166085 no 2634 0.112191172914494 4318 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2481 5478948 45.16 µM -1.21563433385105 0.241021487592407 no 2635 0.112062124506934 4316 77792
SGTC_2739 tacrine 100.86 µM -1.21610168368812 0.240953495936613 no 2636 0.111973094625771 4355 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_873 0591-4978 488 µM -1.21969304460765 0.240431360709096 no 2637 0.111290629636768 4358 3305145
SGTC_3313 9133968 57.047 µM -1.22223514162317 0.240062147043313 no 2638 0.110809359100887 4294 1494643
SGTC_3320 9137005 35.139 µM -1.22268547593062 0.239996772822698 no 2639 0.110724257395081 4343 4908713
SGTC_2848 9016370 25.97 µM -1.22610671125327 0.2395004354102 no 2640 0.110079260319038 4302 7894410
SGTC_3052 9092717 49.47 µM -1.22670322166113 0.239413953781246 no 2641 0.109967078202303 4310 25237534
SGTC_2399 5884133 200 µM -1.22750133634228 0.239298270396085 no 2642 0.109817109926588 4285 722445
SGTC_925 2064-1272 59.6 µM -1.22775062493217 0.239262143317137 no 2643 0.109770297910929 4283 6815817
SGTC_2116 5511452 16.8835 µM -1.23008640124252 0.238923785768392 no 2644 0.109332375912521 4324 870744
SGTC_216 k038-0035 28.382 µM -1.23683650343761 0.237947446994717 no 2645 0.108073893545615 4233 4444231 YPR107C YTH1
SGTC_1353 1498-1206 8.11 µM -1.23732581097553 0.237876758389669 no 2646 0.107983074612258 4348 6756808
SGTC_2677 mitomycin C 100 µM -1.23931068856722 0.237590127971928 no 2647 0.107615230943384 4382 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2839 9003951 25.97 µM -1.24514025033726 0.236749394666259 no 2648 0.106540100489333 4374 2990634
SGTC_539 4859-0462 2.54 µM -1.24578863413149 0.236655986650767 no 2649 0.106421001685362 4345 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_522 1273-0010 11.6 µM -1.25033523776592 0.236001559840309 no 2650 0.10558855562419 4376 5705015
SGTC_1035 k081-0041 55.2 µM -1.25170415601086 0.235804716662243 no 2651 0.105338842570203 4343 731709
SGTC_2439 5492030 7.2 µM -1.25647903202861 0.235118823879544 no 2652 0.104471171722088 4330 5722370
SGTC_2001 4023502 57.655 µM -1.25679922772614 0.235072868442963 no 2653 0.104413172889558 4345 108941 YCR052W RSC6
SGTC_157 1348-1695 65.819 µM -1.26062219935823 0.234524567653151 no 2654 0.103722498286338 4266 5380510
SGTC_481 bay k-8644 50 µM -1.26281808822666 0.234209947578469 no 2655 0.103327281310469 4295 2303 A calcium channel antagonist.
SGTC_2131 toluylene red 5.2905 µM -1.2631071504974 0.234168549053878 no 2656 0.103275337305312 4302 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_716 1683-5115 658 µM -1.2631093995003 0.234168226975144 no 2657 0.103274933237606 4327 723597
SGTC_589 1227-0070 34.1 µM -1.2649731440805 0.233901405258407 no 2658 0.102940477568155 4389 2841384
SGTC_1201 1889-3372 45.9 µM -1.26808186332626 0.233456722660875 no 2659 0.102384358816534 4228 5392199
SGTC_3339 9145883 14.936 µM -1.26904329935594 0.233319290331231 no 2660 0.102212810662302 4246 2030670
SGTC_62 0180-0423 3.232 µM -1.27218804944379 0.232870078227948 no 2661 0.101653156331547 4312 30102 YGL099W LSG1
SGTC_2533 agelasine 13.65 µM -1.27367578309385 0.232657730320879 no 2662 0.101389171170601 4408 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_988 1497-1057 103 µM -1.27518098514307 0.232442998685707 no 2663 0.101122594980917 4323 3533044
SGTC_2836 9010338 19.48 µM -1.27801307930551 0.232039272014999 no 2664 0.100622407300108 4322 2994051
SGTC_1220 1838-0075 193 µM -1.27961226754838 0.231811473727066 no 2665 0.100340766630012 4277 5529645
SGTC_654 1124-0271 80.9 µM -1.28116263964991 0.231590748096324 no 2666 0.100068272857202 4333 5403748
SGTC_2260 7964312 200 µM -1.28388268247125 0.231203780284917 no 2667 0.0995915037222894 4405 231951
SGTC_647 0140-0236 81 µM -1.28421852120954 0.231156027106314 no 2668 0.0995327532263206 4365 990837
SGTC_3272 9137413 49.47 µM -1.28888012511224 0.230493758585134 no 2669 0.0987198823017217 4271 17614870
SGTC_3142 9086498 49.47 µM -1.29370040773634 0.229810063504866 no 2670 0.0978844622302928 4222 25236367
SGTC_894 0960-0238 55.9 µM -1.29537264936175 0.229573143102178 no 2671 0.0975958542119109 4360 6741907 YDL195W SEC31
SGTC_1938 st074717 56.4 µM -1.29593522814372 0.229493468652078 no 2672 0.0974989005557938 4237 17250979
SGTC_2593 nobiletin 86.24 µM -1.29665489959794 0.229391568760084 no 2673 0.0973749768835754 4358 72344 An anti-infammatory.
SGTC_35 0133-0054 64.071 µM -1.29947368448902 0.228992694989619 no 2674 0.0968907093923802 4333 99677
SGTC_3303 9125618 40.5795 µM -1.30139655922757 0.228720820926456 no 2675 0.0965613753951049 4379 22695467
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.30316268099499 0.228471269822106 no 2676 0.0962596139517581 4390 94937 An inhibitor of serotonin biosynthesis.
SGTC_1126 isoteolin 1.0172 µM -1.30379276389267 0.228382276822612 no 2677 0.0961521252452563 4309 133323
SGTC_1506 4226-2149 212 µM -1.30968287305204 0.227551299748314 no 2678 0.095151569934133 4373 991114
SGTC_96 0929-0093 37.281 µM -1.31131349506218 0.227321552746873 no 2679 0.0948759354587583 4381 6991579
SGTC_1121 fusaric acid 630.51 nM -1.31432685888245 0.226897328034794 no 2680 0.0943681161900548 4347 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1831 st055328 12 µM -1.31491316267793 0.226814839458884 no 2681 0.0942695442469504 4359 1103068
SGTC_56 0957-0365 83.25 µM -1.32201239525331 0.225817374015077 no 2682 0.0930820117080212 4345 6752360
SGTC_732 3970-1727 52.7 µM -1.32466908824303 0.225444738836083 no 2683 0.0926404650391539 4464 1275699
SGTC_3002 9075603 71.4286 µM -1.32946789598965 0.22477252772616 no 2684 0.0918468253346189 4334 20105405
SGTC_1288 0973-0013 65.5 µM -1.32950913880706 0.2247667554131 no 2685 0.091840026381943 4426 4315430
SGTC_1553 gossypol 38.6 µM -1.33067596833994 0.224603481681541 no 2686 0.0916478268697396 4285 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_922 1866-0035 480 µM -1.33104129880416 0.224552375050848 no 2687 0.0915877111453024 4308 3156169
SGTC_1965 Pectolinarigenin 58.4 µM -1.33323132272312 0.224246147653799 no 2688 0.0912279516314999 4370 5320438 An anti-inflammatory.
SGTC_2572 astragaloside iv 100 µM -1.33345046765049 0.224215518039578 no 2689 0.0911920100179244 4399 45006101 An anti-inflammatory agent.
SGTC_2115 tiliquinol 12.7705 µM -1.33396806859223 0.22414318303172 no 2690 0.0911071607951048 4371 71208 A bioactive hydroxyquinoline.
SGTC_2487 5918373 44.05 µM -1.33422314796104 0.224107540429465 no 2691 0.0910653677195228 4440 2876279
SGTC_376 3970-0862 59.1 µM -1.33484445420639 0.224020737897363 no 2692 0.0909636302817179 4418 3135186
SGTC_397 arbidol 50 µM -1.34401393761578 0.222741894853043 no 2693 0.089471939971963 4428 131410 A RNA synthesis inhibitor.
SGTC_1177 0983-0204 23.6 µM -1.34932929803093 0.222002484894233 no 2694 0.0886156095567246 4418 766818
SGTC_537 1334-0398 209 µM -1.35092772553878 0.221780404982595 no 2695 0.0883592928866312 4424 5846986
SGTC_1645 Cervolide 78 µM -1.35519632320321 0.221187963381457 no 2696 0.0876775079178497 4415 23173 A fragrance.
SGTC_2276 7947513 42.08 µM -1.35558676125194 0.221133819447152 no 2697 0.0876153431959736 4342 2105100
SGTC_99 0109-0120 622.8 µM -1.35748956712854 0.220870056703856 no 2698 0.0873128530955558 4410 759414
SGTC_546 peri-Naphthalide 147 µM -1.35901250940754 0.220659079649105 no 2699 0.0870713123784832 4354 223824 A penicillin ester.
SGTC_2928 9011484 9.79 µM -1.36063648211176 0.220434233827289 no 2700 0.0868142982794852 4404 2994751
SGTC_1354 1498-1681 81 µM -1.36449989735515 0.219899855919249 no 2701 0.0862051432416482 4395 5754243
SGTC_78 0336-0123 156.75 µM -1.36482137398492 0.219855423607602 no 2702 0.0861545996080407 4254 6765896
SGTC_1997 st073024 93.8 µM -1.36690056426543 0.219568176542489 no 2703 0.0858282375613187 4444 686268
SGTC_3237 9133362 49.47 µM -1.36789115367943 0.219431399160885 no 2704 0.0856730746014792 4376 43845137
SGTC_1799 st045822 46.1415 µM -1.36812160357062 0.219399586405765 no 2705 0.0856370077504391 4394 3674992
SGTC_610 4215-0184 155 µM -1.36900228370753 0.21927803618807 no 2706 0.0854992805266222 4425 5605015
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.37197709460192 0.218867743316837 no 2707 0.0850352842407371 4341 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_339 3091-4833 71.4 µM -1.37285299898037 0.218747020760591 no 2708 0.0848990253216387 4252 3240077
SGTC_1307 1187-1599 12.2 µM -1.37542989039167 0.218392079946593 no 2709 0.0844991037609162 4411 1538471
SGTC_394 menadione 8.33 µM -1.38144982998425 0.217564187883128 no 2710 0.0835703467863374 4447 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_883 0850-0245 24.6 µM -1.38556114965814 0.216999821187922 no 2711 0.0829404740867108 4482 6823229 YPR165W RHO1
SGTC_316 k060-0003 58.6 µM -1.38746927039469 0.216738178469654 no 2712 0.0826493575892325 4454 6152314
SGTC_169 k015-0017 16.025 µM -1.38751703318037 0.216731631547661 no 2713 0.0826420804367891 4420 1840002
SGTC_88 0180-0332 8.668 µM -1.38955438152907 0.216452475426902 no 2714 0.0823321182430832 4523 3101745
SGTC_313 3474-0040 5.03 µM -1.39061555712306 0.216307156302391 no 2715 0.0821710181250158 4443 1043375 YIL048W NEO1
SGTC_801 0866-0028 10.1 µM -1.39073229196921 0.21629117389019 no 2716 0.0821533107791202 4459 6849771
SGTC_945 3381-0768 11.3 µM -1.39164825951351 0.216165790585541 no 2717 0.0820144686897145 4435 1126236 YIL048W NEO1
SGTC_440 fluspirilene 35.1 µM -1.39280019955503 0.216008165673579 no 2718 0.0818401090329841 4458 3396 An atypical antipsychotic.
SGTC_2060 5238662 140 µM -1.39522022801641 0.215677239729639 no 2719 0.0814747194851226 4403 790130
SGTC_3068 9116768 49.47 µM -1.39578716728048 0.215599756335296 no 2720 0.0813892979382432 4391 41904888
SGTC_2208 7283366 200 µM -1.39594063713238 0.215578784439885 no 2721 0.0813661860392188 4431 898663
SGTC_2348 9022543 33.42 µM -1.39679173507346 0.215462502048055 no 2722 0.081238104198019 4436 3162678 YDL140C RPO21
SGTC_1648 st011736 69.8 µM -1.39822202270022 0.215267169061221 no 2723 0.0810232027266516 4418 2855514
SGTC_8 0354-0001 70 µM -1.4038281510046 0.21450253709119 no 2724 0.0801850144918365 4440 4993152
SGTC_3248 9135562 49.47 µM -1.40851695222659 0.213864235696541 no 2725 0.0794890254154411 4438 17650701
SGTC_2054 5233173 129 µM -1.40913058443192 0.213780781916517 no 2726 0.0793982793594828 4441 6889
SGTC_2342 7990637 118.86 µM -1.41077249884747 0.213557575379544 no 2727 0.0791558529812257 4425 2033102 YER133W GLC7
SGTC_524 r073-0010 27.8 µM -1.41420859329224 0.21309090259074 no 2728 0.0786503328032454 4378 2772106
SGTC_379 3970-0972 5.9 µM -1.41448010379287 0.213054052799736 no 2729 0.0786104925688251 4440 2898042 YBL034C STU1
SGTC_2605 digitonin 300 nM -1.4145633551053 0.213042754558066 no 2730 0.078598279708773 4447 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3262 9137218 49.47 µM -1.41465312433992 0.213030572144722 no 2731 0.0785851122894042 4414 17650664
SGTC_3326 9140064 16.379 µM -1.41503673885163 0.212978517123244 no 2732 0.0785288622604787 4396 1868434
SGTC_22 0964-0034 14.468 µM -1.41586251012115 0.212866488309131 no 2733 0.0784078816247672 4449 138402
SGTC_3103 9120822 49.47 µM -1.41671265777629 0.212751188395975 no 2734 0.078283477382297 4454 17141819
SGTC_2225 6654152 15.4 µM -1.4170313793935 0.212707971686136 no 2735 0.0782368766450849 4384 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1640 st009078 66.4 µM -1.41813983711079 0.212557711488624 no 2736 0.0780749712919864 4417 690618
SGTC_555 4296-0685 37 µM -1.41941967267533 0.212384296811361 no 2737 0.0778883501798894 4432 2908540 YHR072W ERG7
SGTC_319 1348-1596 45.5 µM -1.4244815588758 0.21169923383269 no 2738 0.0771535598149994 4511 5380505
SGTC_1944 st076371 56.9 µM -1.42831162351183 0.211181743061175 no 2739 0.0766010918555482 4413 24208455
SGTC_2183 6420625 130.508 µM -1.42848665650428 0.211158111587931 no 2740 0.0765759162900524 4487 2897619
SGTC_2690 usnic acid 100 µM -1.42977985924986 0.210983562324418 no 2741 0.0763901057088845 4459 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1134 3477-0009 42.5 µM -1.4318093995673 0.210709796953479 no 2742 0.0760991882406802 4501 3973534
SGTC_1792 st045773 43.6 µM -1.43878667763341 0.209770220634 no 2743 0.0751054860596318 4445 2919270
SGTC_2166 5933061 31.504 µM -1.43917102711884 0.209718534928696 no 2744 0.0750510360154083 4504 2877375
SGTC_150 3970-0969 77.2 µM -1.43930892418435 0.209699992935596 no 2745 0.0750315077462023 4498 6615640
SGTC_2427 5545055 42.75 µM -1.44047062709815 0.209543825653901 no 2746 0.0748671471977535 4394 5372858
SGTC_2929 9013348 24.6 µM -1.4405467419995 0.209533595945176 no 2747 0.0748563878719998 4425 2995952
SGTC_1550 gossypolone 36.6 µM -1.44137509762983 0.209422285403871 no 2748 0.074739370795311 4490 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2084 5306078 60.6385 µM -1.44169163711983 0.209379759502723 no 2749 0.0746946919445913 4405 679340
SGTC_690 glyoxal 20.3 µM -1.44295904497761 0.209209538892631 no 2750 0.0745160042817906 4266 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_225 nsc-122657 1.016 µM -1.44587606276089 0.208818075259662 no 2751 0.0741059834846017 4473 275685
SGTC_1801 st050089 28.441 µM -1.45421107651817 0.207701898084336 no 2752 0.0729438975051309 4513 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_90 0870-0863 4.608 µM -1.45504624043611 0.207590252334704 no 2753 0.0728282302884204 4478 1738164
SGTC_245 methotrexate 289.6 µM -1.45593800159055 0.207471079753369 no 2754 0.0727048796301779 4423 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_328 k915-0120 63.5 µM -1.45662161597077 0.207379750739021 no 2755 0.0726104287384741 4479 6624543
SGTC_4 0960-0234 25.671 µM -1.45807802110656 0.207185258265853 no 2756 0.0724095193983842 4465 6821112
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.45895981946598 0.207067552865217 no 2757 0.0722880835416418 4481 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2781 5567276 71.43 µM -1.45941738255425 0.207006491404263 no 2758 0.0722251322950572 4468 2853274
SGTC_287 k060-0039 29.6 µM -1.45944576347365 0.20700270434219 no 2759 0.072221229049989 4501 5861974
SGTC_1591 genipin 88.4 µM -1.45946846834652 0.206999674703722 no 2760 0.0722181065514498 4487 442424 A DNA cross-linking agent.
SGTC_2302 7771753 200 µM -1.46010475275542 0.206914782378992 no 2761 0.0721306433054949 4446 2203047
SGTC_3246 9135460 32.98 µM -1.46441794753929 0.206339864413828 no 2762 0.0715398936229575 4443 41446951
SGTC_1758 st042942 75.2445 µM -1.46628598734727 0.206091162163364 no 2763 0.0712851956640083 4445 669317
SGTC_3261 9137475 49.47 µM -1.46930419843253 0.20568970719599 no 2764 0.0708751492875554 4485 17027690
SGTC_2798 7813637 45.45 µM -1.47006746611378 0.205588257851801 no 2765 0.0707717413143657 4466 956368
SGTC_3226 9131256 49.47 µM -1.47193576614834 0.205340059056157 no 2766 0.0705191120684681 4479 17178073
SGTC_899 1083-0020 478 µM -1.47379088872272 0.205093787041702 no 2767 0.0702689511225214 4522 767123
SGTC_1430 4049-0248 69.1 µM -1.47439942240567 0.205013040972805 no 2768 0.0701870399428051 4507 22774488
SGTC_2580 diallyl disulphide 81.36 µM -1.4745413697772 0.204994208756426 no 2769 0.0701679438001535 4476 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1686 st019653 115.5 µM -1.47827402695725 0.204499364746196 no 2770 0.0696672233580667 4479 97252
SGTC_2610 ononetin 44.17 µM -1.47852287899559 0.204466399351679 no 2771 0.0696339389529237 4460 259632
SGTC_967 1306-0166 352 µM -1.47895243423397 0.204409503671851 no 2772 0.0695765139791754 4483 4437607
SGTC_29 0299-0004 12.984 µM -1.48218915248882 0.203981095262418 no 2773 0.0691449860383327 4391 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2563 tomatine 8.54 µM -1.4836180461746 0.203792138838064 no 2774 0.0689551395472608 4434 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_743 1275-0778 158 µM -1.48697476497409 0.203348658124235 no 2775 0.0685107379931382 4461 2849257 YMR203W TOM40
SGTC_2970 9090938 41.86 µM -1.48755672161956 0.203271830182989 no 2776 0.0684339170161328 4523 17217104
SGTC_3269 9137823 49.47 µM -1.49292560547573 0.202563865815623 no 2777 0.067728330857422 4430 17682936
SGTC_2571 chrysanthemic acid 100 µM -1.49342388650551 0.202498235141319 no 2778 0.0676631321070176 4467 2743 An insecticide.
SGTC_1555 citronellol 128 µM -1.49523910607821 0.202259252530984 no 2779 0.0674260254565821 4456 8842 A terpine precursor.
SGTC_1856 st057054 55.7 µM -1.5006330466908 0.201550109825058 no 2780 0.0667252495046241 4470 1266018
SGTC_1055 3448-0672 86 µM -1.50218189229105 0.201346758327075 no 2781 0.0665250699862464 4457 748378
SGTC_620 0109-0052 432 µM -1.5116341748904 0.200108414100278 no 2782 0.0653134763547261 4542 493037
SGTC_2635 hydroquinidine 100 µM -1.51356739580238 0.199855707757605 no 2783 0.0650677978335894 4432 442912 An experimental heart treatment.
SGTC_645 0845-0943 5.41 µM -1.51371813098821 0.199836012058427 no 2784 0.0650486722131325 4527 1885106
SGTC_291 SEC14.278 35.5 µM -1.51410544882992 0.199785408819394 no 2785 0.0649995484607321 4515 1068044
SGTC_2853 9015042 58.44 µM -1.51824701195592 0.199244793869868 no 2786 0.0644760700566848 4437 6457456
SGTC_1228 0124-0032 52.5 µM -1.52000091731409 0.199016115337828 no 2787 0.064255372545074 4528 X1228
SGTC_839 0122-0028 230 µM -1.52712982992169 0.198088259033663 no 2788 0.0633643653229373 4526 759448
SGTC_2926 9010726 65.15 µM -1.53153284176227 0.197516496620727 no 2789 0.06281887804899 4499 2994293
SGTC_3025 9087895 49.47 µM -1.53398190535234 0.197198900586119 no 2790 0.0625170521845497 4489 17173641
SGTC_2913 7966556 36.57 µM -1.53563432783478 0.196984788113998 no 2791 0.0623140450132512 4412 2976516
SGTC_2489 cantharidin 73.42 µM -1.5362210443946 0.196908798242004 no 2792 0.0622420881801696 4477 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3033 9090887 49.47 µM -1.53697925801787 0.196810622845486 no 2793 0.0621491944031401 4524 19325384
SGTC_1413 3910-0535 34.4 µM -1.54433527478651 0.195859686931091 no 2794 0.0612535656197814 4538 2876951
SGTC_3225 9130819 49.47 µM -1.5462218182667 0.19561625735405 no 2795 0.0610255029709835 4477 4547121
SGTC_861 0443-0273 110 µM -1.54963060366922 0.195176871835008 no 2796 0.0606151015791324 4512 6149169
SGTC_45 0kpi-0036 14.9 µM -1.54972306301111 0.195164962374631 no 2797 0.0606040000670328 4495 2795021
SGTC_21 0849-0113 22.993 µM -1.55102829923623 0.194996885236802 no 2798 0.060447451153307 4500 1560156
SGTC_467 ro 31-8220 72.8 µM -1.55173906665005 0.194905395720458 no 2799 0.0603623354895651 4500 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3165 9101544 49.47 µM -1.5529354591717 0.194751455818431 no 2800 0.0602192772040852 4510 5002184
SGTC_269 exalamide 29 µM -1.55327373505828 0.194707943254784 no 2801 0.0601788761319031 4496 3316 A derivative of salicylamide.
SGTC_48 0382-0018 55 µM -1.5544454115506 0.194557275762153 no 2802 0.0600391041124886 4545 762596
SGTC_582 0987-0078 156 µM -1.55479651422332 0.194512140806315 no 2803 0.0599972697947795 4561 1625765
SGTC_797 k781-0471 270 µM -1.55930445083406 0.193933202828693 no 2804 0.0594621693995836 4498 23738129
SGTC_1422 4031-0024 15.5 µM -1.56009730333184 0.193831488347207 no 2805 0.0593684443688674 4468 782427
SGTC_3175 9106517 49.47 µM -1.56317693671197 0.193436712929876 no 2806 0.0590054916319434 4544 41468073
SGTC_145 3737-0113 38.366 µM -1.5658330940682 0.193096616811365 no 2807 0.0586938482039723 4512 6849351
SGTC_106 0092-0003 11.579 µM -1.56691858485024 0.192957735010106 no 2808 0.0585668614984161 4448 1072148
SGTC_2336 9001819 198.65 µM -1.56746745916217 0.192887533179917 no 2809 0.0585027333130727 4531 2989602
SGTC_493 zm226600 134 µM -1.56806191138976 0.192811519467554 no 2810 0.0584333422011046 4530 5240098 A potassium channel opener. YCR052W RSC6
SGTC_919 tnp00227 403.569 nM -1.57087593648145 0.192451933267394 no 2811 0.0581057345350524 4496 1269246 A methoxyflavone. YNL221C POP1
SGTC_1434 4073-0095 163 µM -1.57581465518399 0.191821838162942 no 2812 0.0575342619791776 4536 24133745
SGTC_1565 sinapyl alcohol 95.1 µM -1.57825622711769 0.191510802894106 no 2813 0.0572533788167451 4531 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2245 6637752 200 µM -1.57923900533895 0.191385692666187 no 2814 0.0571406231778515 4546 681890
SGTC_1884 5633444 25 µM -1.58009093562579 0.191277280259323 no 2815 0.0570430214200946 4479 5724239
SGTC_2968 9090663 33.37 µM -1.58669129151968 0.190438627985142 no 2816 0.056291289821766 4473 25236811
SGTC_1498 4478-3555 97.6 µM -1.58696069071606 0.190404445703399 no 2817 0.0562607739361065 4545 3437919
SGTC_2505 galangin 7.89 µM -1.58737661302222 0.190351679473507 no 2818 0.0562136864258059 4467 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_500 h-89 112 µM -1.59066223323735 0.189935163100826 no 2819 0.0558428053338172 4509 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2859 9028643 45.46 µM -1.5910867950899 0.189881382521787 no 2820 0.055795021932789 4373 17151580
SGTC_228 caffeine 993.056 µM -1.59180198119352 0.18979080883132 no 2821 0.0557146024336977 4542 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3194 9111903 49.47 µM -1.59217969238957 0.189742984876099 no 2822 0.0556721674149294 4529 17087251
SGTC_1276 0871-0068 94.2 µM -1.59341271832972 0.189586916721152 no 2823 0.0555338172041943 4549 3414906
SGTC_1756 st041558 35.5 µM -1.59643431740391 0.189204797003762 no 2824 0.0551959297023988 4613 3955792
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.59713305724171 0.189116500002162 no 2825 0.0551180254213356 4573 5106787 A p450 inhibitor.
SGTC_952 1185-0122 232 µM -1.59779921813361 0.189032343507263 no 2826 0.0550438343592571 4508 678600
SGTC_3265 9137266 49.47 µM -1.60147477586837 0.188568423028301 no 2827 0.0546359012357982 4523 17224265
SGTC_2753 fluvastatin 17.09 µM -1.60336295470917 0.188330374600993 no 2828 0.0544272724231411 4526 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2915 7971052 15.16 µM -1.60619620095626 0.187973526630762 no 2829 0.0541154039108565 4512 5741558
SGTC_1675 st018485 24.5 µM -1.60687440215002 0.187888169006262 no 2830 0.0540409613636531 4536 3323024
SGTC_1916 st067606 49.2 µM -1.60745520483191 0.187815088874868 no 2831 0.0539772741880538 4449 19590279
SGTC_885 0865-0106 16.8 µM -1.60841463788373 0.187694405621129 no 2832 0.053872198943224 4516 2793380
SGTC_1211 1056-0033 32.3 µM -1.60910630894496 0.187607432801934 no 2833 0.0537965489866949 4587 6741922
SGTC_32 0928-0142 34.1 µM -1.61145064645847 0.18731283395362 no 2834 0.0535407679956888 4557 2244242
SGTC_1405 3909-7894 12 µM -1.61429585679014 0.186955677848914 no 2835 0.0532316341878782 4546 7104060
SGTC_2217 6934799 96.0675 µM -1.61509359389143 0.186855614473366 no 2836 0.0531452140196145 4531 675606
SGTC_2325 6158266 200 µM -1.61822103747768 0.186463646397256 no 2837 0.0528074853263798 4528 3623240
SGTC_114 0364-0001 490.298 µM -1.62316962099538 0.185844472953146 no 2838 0.0522765750117263 4551 4003655
SGTC_2000 st075254 36.4 µM -1.62444455457474 0.185685158359994 no 2839 0.0521404823200409 4438 17234175
SGTC_297 0986-0032 24 µM -1.62580497051459 0.185515255438333 no 2840 0.0519955753259556 4525 2847425
SGTC_3353 9151644 39.2805 µM -1.62726472447513 0.185333053497144 no 2841 0.051840443229655 4564 4909158
SGTC_3235 9132602 49.47 µM -1.62824366498116 0.185210927453304 no 2842 0.0517366147250391 4541 4912240
SGTC_1460 k062-0059 9.15 µM -1.63028417436633 0.184956527909513 no 2843 0.0515207253663561 4448 1373085
SGTC_691 1548-0686 185 µM -1.63364858653217 0.184537545823928 no 2844 0.0511663298192863 4533 46495133
SGTC_3048 9093155 49.47 µM -1.63369059410964 0.184532318206394 no 2845 0.0511619171785372 4553 25236002
SGTC_1071 trifluoperazine 6.31 µM -1.63914136367975 0.183854780666796 no 2846 0.0505919111146774 4611 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1712 st032288 53.4 µM -1.64425082923641 0.183221076500572 no 2847 0.0500622007559579 4361 2883011
SGTC_2044 5102272 200 µM -1.64443947256304 0.18319770601768 no 2848 0.0500427286290619 4567 592666
SGTC_3029 9088683 49.47 µM -1.64664465456547 0.182924650232422 no 2849 0.0498155531404021 4573 25236615
SGTC_288 1315-0019 35.1 µM -1.65362076402723 0.182062510098772 no 2850 0.0491022955457491 4597 6811474
SGTC_2965 9082772 38.63 µM -1.65478252438496 0.181919181489509 no 2851 0.0489843100489827 4548 16459634
SGTC_453 enantio-paf c16 10 µM -1.65775427856512 0.181552871692148 no 2852 0.0486835366091099 4177 13871343 A lipid and platelet activating factor
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.6580974223327 0.181510604227751 no 2853 0.0486489020528537 4574 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2738 aclarubicin 5.55 µM -1.66596716570426 0.180542922817229 no 2854 0.0478599771991613 4619 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2532 xanthone 78.9 µM -1.6716379599833 0.179847638879905 no 2855 0.0472978673269602 4586 7020 An insecticide.
SGTC_73 0327-0325 16.231 µM -1.67668379742892 0.179230395598203 no 2856 0.0468021653121477 4391 53298
SGTC_2930 9013230 14.89 µM -1.67749211233317 0.179131640635654 no 2857 0.0467231452929827 4551 2995857
SGTC_2262 9014885 67.46 µM -1.68063441411381 0.178748058720352 no 2858 0.0464169735010922 4625 6457424
SGTC_3210 9128157 49.47 µM -1.68255960339226 0.178513305824565 no 2859 0.0462301887168831 4525 17590849
SGTC_2746 daunorubicin 9.88 µM -1.68338099176208 0.178413206853952 no 2860 0.0461506802872242 4611 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_156 3474-0145 5.642 µM -1.68380639977498 0.178361378161933 no 2861 0.0461095449987625 4509 2265471
SGTC_404 fumagillin 50 µM -1.68491128342198 0.178226811303555 no 2862 0.0460028446402638 4590 12015870 A methionine aminopeptidase binder.
SGTC_2943 9068529 45.32 µM -1.68981291332491 0.177630600019128 no 2863 0.0455318762628524 4538 3270634
SGTC_3341 9147222 25.867 µM -1.69212400329776 0.17734992698055 no 2864 0.0453111663430962 4592 1939759
SGTC_1877 wortmannin 25 µM -1.69714893155891 0.176740635593875 no 2865 0.0448342536150232 4602 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2902 5787006 60.46 µM -1.69828953035164 0.176602518215111 no 2866 0.0447265648850924 4566 591003
SGTC_880 0833-0487 87.2 µM -1.70404110024808 0.175907089458909 no 2867 0.0441867045408428 4584 76075
SGTC_1630 st005209 31.3 µM -1.70618371037155 0.175648468039065 no 2868 0.0439869403304615 4591 3367314
SGTC_116 0155-0182 31.788 µM -1.70858058380302 0.175359441706444 no 2869 0.0437643338708612 4449 771486
SGTC_3277 9138724 49.47 µM -1.70900345258552 0.175308481497629 no 2870 0.0437251549713369 4564 15943418
SGTC_1889 st059080 5.18 µM -1.70915792070364 0.175289868779884 no 2871 0.043710850519704 4565 176925 Isolated from Daphnopsis sellowiana.
SGTC_1808 st050063 61.5 µM -1.71434657229441 0.174665387537792 no 2872 0.0432325472970012 4550 4011993
SGTC_254 nsc-64875 3.808 µM -1.71646583096437 0.174410730514189 no 2873 0.0430384083286042 4598 56993
SGTC_247 mechlorethamine 29.705 µM -1.71680886976536 0.174369532044336 no 2874 0.0430070498982042 4571 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2196 6573537 42.6665 µM -1.71953915787552 0.174041848803383 no 2875 0.0427581219425911 4621 2903087
SGTC_3069 9117009 49.47 µM -1.72070709806736 0.173901794790878 no 2876 0.0426519938540684 4607 41904981
SGTC_3282 9108498 15.4605 µM -1.72116489561003 0.173846917373902 no 2877 0.0426104529670682 4580 16459645
SGTC_3199 9111318 49.47 µM -1.72208033722751 0.173737213972392 no 2878 0.0425274832315007 4515 8548020
SGTC_3352 9151559 45.5865 µM -1.72691033381761 0.17315913299369 no 2879 0.0420918841227537 4595 17159339
SGTC_994 3910-0338 138 µM -1.73386018254291 0.172329488451023 no 2880 0.0414714471146539 4624 3479481
SGTC_253 dyclonine 31.25 µM -1.73606999851047 0.172066221894792 no 2881 0.0412757291902249 4687 3180 An oral anasthetic.
SGTC_3153 9100258 49.47 µM -1.73635575452181 0.172032197090294 no 2882 0.0412504752488681 4517 25236848
SGTC_1090 efavirenz 20.7 µM -1.7369969021824 0.17195587163599 no 2883 0.0411938588341004 4612 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3188 9110789 49.47 µM -1.73900873265873 0.17171651356379 no 2884 0.0410166134395554 4569 849217
SGTC_1707 st032323 6.317 µM -1.74410990709127 0.171110554457475 no 2885 0.040569963429852 4420 3132057 YMR211W DML1
SGTC_2002 4023503 131 µM -1.74424165992066 0.171094921920492 no 2886 0.0405584798916522 4587 4736863 YCR052W RSC6
SGTC_757 1066-0008 322 µM -1.74817601555665 0.170628529658216 no 2887 0.0402167766891095 4613 6842497
SGTC_895 0964-0006 13.7 µM -1.74859961654872 0.17057836309436 no 2888 0.0401801263214383 4611 6738897
SGTC_97 0535-0701 19.132 µM -1.75050404979016 0.170352940000137 no 2889 0.0400156879757001 4530 2832013 YGL099W LSG1
SGTC_851 0394-0702 453 µM -1.75239044151084 0.170129840641886 no 2890 0.0398533469552777 4617 762646
SGTC_744 1594-0068 283 µM -1.75265858329132 0.170098143315022 no 2891 0.0398303144552779 4602 668392
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.75486165700567 0.169837858917981 no 2892 0.0396414870469915 4614 688662
SGTC_1399 3562-5772 25 µM -1.75576658069425 0.169731019817929 no 2893 0.0395641364474487 4613 23847490
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.76517757024041 0.168622474779265 no 2894 0.0387669635142695 4605 688798
SGTC_2805 7950783 58.44 µM -1.7672158522629 0.168382994732041 no 2895 0.0385960429335358 4602 1178958 YDL195W SEC31
SGTC_1780 st038448 24.544 µM -1.7679668317858 0.168294816470016 no 2896 0.0385332243889728 4623 728868 YDL195W SEC31
SGTC_490 phenamil 164 µM -1.76931604297174 0.168136469874305 no 2897 0.0384205738157781 4633 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3224 9130643 49.47 µM -1.77435340736677 0.167546120355827 no 2898 0.0380023557985386 4613 17644395
SGTC_2375 9072683 200 µM -1.7781708962821 0.167099623572547 no 2899 0.0376878956693549 4643 16798029
SGTC_721 1187-1332 279 µM -1.78231294174801 0.16661603501201 no 2900 0.0373491067044633 4625 25730
SGTC_1612 st002233 45.4 µM -1.78269942601686 0.166570958647389 no 2901 0.0373176224205412 4634 1035021
SGTC_1722 st034304 3.6505 µM -1.79001901228424 0.165718748394673 no 2902 0.0367254275152497 4562 4036148 YLR033W RSC58
SGTC_2076 5212012 200 µM -1.79048804628138 0.165664235631931 no 2903 0.0366877436173481 4608 604802
SGTC_670 4204-0025 119 µM -1.79319156493317 0.165350249358344 no 2904 0.0364711491906283 4640 719039
SGTC_1039 k821-0043 94 µM -1.79457852845501 0.165189317151799 no 2905 0.0363604383255081 4599 15992768
SGTC_3161 9100388 49.47 µM -1.79979425416275 0.164585033656841 no 2906 0.0359465657874632 4678 25236368
SGTC_3096 9117468 49.47 µM -1.80372494027407 0.164130580049141 no 2907 0.0356372188684201 4599 41316311
SGTC_2541 muurolladie-3-one 83.07 µM -1.80768812359641 0.163673194048622 no 2908 0.0353275270226798 4559 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1060 3448-7350 82 µM -1.80897946436191 0.163524340945226 no 2909 0.0352270968808121 4584 570178
SGTC_1371 2421-0008 32.7 µM -1.81412434376766 0.162932162846654 no 2910 0.0348292922363849 4622 2827552
SGTC_3012 9080433 71.4286 µM -1.81425386802304 0.162917272557236 no 2911 0.0348193251472769 4614 17688859
SGTC_2485 5633444 17.78 µM -1.8171229434182 0.162587666514084 no 2912 0.0345991451995828 4605 5724239
SGTC_1739 st037196 92.5 µM -1.81759652885556 0.162533301666187 no 2913 0.0345629112824576 4630 612214
SGTC_1976 st070609 63.5 µM -1.82792532761864 0.161350558361011 no 2914 0.0337803796403638 4592 682556
SGTC_1168 k815-0004 80.5 µM -1.82984327559067 0.161131555020163 no 2915 0.0336366887984041 4639 642433
SGTC_2793 7325131 81.82 µM -1.82987509097164 0.161127923776365 no 2916 0.033634309468244 4589 4176441
SGTC_2037 5169046 200 µM -1.83140343935195 0.160953548852961 no 2917 0.0335201741693145 4679 5718022
SGTC_2827 7993847 71.43 µM -1.83325634889734 0.160742308796349 no 2918 0.0333822287915567 4660 2985692
SGTC_2367 9070478 135.38 µM -1.83515241538883 0.160526336146043 no 2919 0.0332415547130524 4579 572802
SGTC_170 4197-0004 226 µM -1.83516603180403 0.160524785845555 no 2920 0.0332405462445521 4635 218692
SGTC_1606 st000094 49.2 µM -1.83969877673546 0.160009252563896 no 2921 0.0329062366274398 4656 1242210
SGTC_809 3998-0021 90 µM -1.85072716457935 0.158759461964111 no 2922 0.0321044070080954 4611 715485
SGTC_431 k089-0097 107 µM -1.85248436281165 0.158560920344913 no 2923 0.0319781504852047 4350 5499420
SGTC_3072 9116419 49.47 µM -1.85402557256758 0.15838691684271 no 2924 0.0318677507579933 4635 17170162
SGTC_686 1319-0111 510 µM -1.85666030263778 0.158089744472665 no 2925 0.0316797493446226 4652 4562600
SGTC_2917 7979103 53.79 µM -1.86232366726737 0.157452210724563 no 2926 0.031278740700964 4628 2980565
SGTC_452 diindolylmethane 8 µM -1.86252796332669 0.157429244420504 no 2927 0.0312643538203152 4623 3071 Inhibits expression of several cancer promoting factors.
SGTC_1948 st076329 66.6 µM -1.86334815702153 0.157337063055539 no 2928 0.0312066494476378 4562 24208413
SGTC_2708 st078559 56 µM -1.86435132814012 0.157224365152333 no 2929 0.031136191572233 4616 17250902
SGTC_219 mitoxanthrone 164.414 µM -1.86581540897441 0.157059983171789 no 2930 0.0310335978637525 4621 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2326 6164455 177.58 µM -1.8674151795266 0.156880495702314 no 2931 0.0309218158245799 4566 2888790
SGTC_852 0418-0143 439 µM -1.87045949033337 0.156539309863597 no 2932 0.0307100186978742 4636 5369229
SGTC_3075 9116269 49.47 µM -1.87539978444264 0.155986675444442 no 2933 0.0303688723872996 4632 17015205 YNL244C SUI1
SGTC_1692 fluoroquinolonic acid 71 µM -1.87565364138755 0.155958313110694 no 2934 0.0303514277523705 4660 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2666 tannic acid 100 µM -1.87655824229056 0.155857273620898 no 2935 0.0302893325545919 4628 16134267 A thiamine antagonist.
SGTC_916 4466-0038 42 nM -1.87680419212068 0.155829809693186 no 2936 0.0302724678517227 4680 5722064 YGL116W CDC20
SGTC_1078 idebenone 36.1 µM -1.87999408332786 0.155473900335646 no 2937 0.0300544421465812 4673 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_712 r015-0009 80.6 µM -1.88061880604004 0.155404260290168 no 2938 0.0300118958320677 4679 6813872 YLR060W FRS1
SGTC_818 4072-2707 53.5 µM -1.88938439219337 0.154429300252159 no 2939 0.0294201703610406 4598 882871
SGTC_508 roscovitine 141 µM -1.89183633394629 0.154157306206276 no 2940 0.0292563953043022 4708 160355 A CDKinase inhibitor.
SGTC_2241 6772625 37.8075 µM -1.89516120276452 0.153788984785311 no 2941 0.0290355241843205 4460 2285411
SGTC_1 0258-0098 57.368 µM -1.89579706872032 0.153718611406179 no 2942 0.0289934418216794 4576 6790032 YDR047W HEM12
SGTC_2526 patulin 37.61 µM -1.89668507557752 0.153620368443833 no 2943 0.028934757305376 4648 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2380 9035439 200 µM -1.89761277292984 0.153517778811646 no 2944 0.0288735552918198 4682 6462575
SGTC_2909 7941780 10.49 µM -1.89826485527768 0.153445695291639 no 2945 0.0288306005735996 4627 1243215
SGTC_3080 9117754 49.47 µM -1.90314323413942 0.152907133136493 no 2946 0.0285109289259337 4650 9550191
SGTC_1689 st020265 53.493 µM -1.90500478572888 0.152701952771427 no 2947 0.0283897245067255 4647 5758320 YPR016C TIF6
SGTC_1007 4101-0031 70 µM -1.90958591578291 0.152197798311715 no 2948 0.0280932749783508 4653 1146276
SGTC_326 k292-0812 17.5 µM -1.91003475252958 0.152148463232198 no 2949 0.0280643694473402 4664 3579357
SGTC_3270 9137563 49.47 µM -1.9168833615048 0.151396997529108 no 2950 0.0276263756593018 4660 17015724
SGTC_1637 st007924 17.4 µM -1.9176362328701 0.151314539322136 no 2951 0.0275785762468018 4595 683336
SGTC_2258 7960471 200 µM -1.9181473511247 0.151258576141052 no 2952 0.0275461649180509 4675 2974708
SGTC_39 0986-0283 58.349 µM -1.91938392328087 0.151123238768359 no 2953 0.0274678820098717 4678 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_512 prima-1 270 µM -1.92012219410543 0.151042476701558 no 2954 0.0274212332495536 4666 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1961 st076550 68.7 µM -1.92131153103103 0.150912431325831 no 2955 0.0273462221409231 4674 1579337
SGTC_1331 1472-0049 76.2 µM -1.92215225681717 0.150820549026447 no 2956 0.0272933011343384 4650 24051409
SGTC_2935 9038016 29.96 µM -1.92438368206176 0.150576858847758 no 2957 0.0271532541499552 4614 6463195
SGTC_2888 9058547 12.99 µM -1.92484222151024 0.150526815030029 no 2958 0.0271245500402013 4607 16476514
SGTC_660 4031-1742 102 µM -1.92622848151947 0.150375589554246 no 2959 0.0270379254915047 4561 6738706
SGTC_1404 3909-7820 48.3 µM -1.9277138269176 0.150213667348016 no 2960 0.0269453656456856 4646 23741373
SGTC_3081 9117243 49.47 µM -1.92880437803161 0.150094856926317 no 2961 0.0268775760670982 4629 45595589
SGTC_1316 1272-0050 65.9 µM -1.9305920545904 0.149900233513348 no 2962 0.0267667606098643 4676 7340392
SGTC_2490 carminic acid 95.39 µM -1.93600712293608 0.149311725281038 no 2963 0.0264334142921948 4663 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2890 9046729 58.44 µM -1.94134054501561 0.148733600213034 no 2964 0.0261084923514248 4646 903329
SGTC_2350 9023895 38.85 µM -1.94381017638951 0.148466407925806 no 2965 0.0259591730713336 4619 2997209
SGTC_151 3013-0144 2.285 µM -1.94726402879394 0.148093270304957 no 2966 0.0257515444377767 4444 906558 YHR107C CDC12
SGTC_1323 1348-1351 11.2 µM -1.94817373774995 0.147995094229399 no 2967 0.0256970890464468 4664 6989654
SGTC_3300 9124615 50.48 µM -1.94862316768974 0.147946607690382 no 2968 0.025670221658577 4657 24824903
SGTC_1001 4048-4355 44.4 µM -1.95076728114651 0.147715437399889 no 2969 0.0255423678221692 4663 21824233
SGTC_1226 3909-7979 35.4 µM -1.95781550693698 0.146957229402936 no 2970 0.0251258325774797 4656 6615510
SGTC_3323 9138564 53.9225 µM -1.95840946426307 0.146893454313832 no 2971 0.0250909925573244 4692 43912313 YNL103W MET4
SGTC_2675 theaflavin digallate 100 µM -1.96214875135422 0.146492381507913 no 2972 0.0248725842484208 4630 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.96470192452074 0.146218952980276 no 2973 0.0247243735414513 4691 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1605 st000082 49.1 µM -1.96541605625373 0.146142535418167 no 2974 0.0246830513137967 4656 1114022
SGTC_1967 st070177 51.4 µM -1.96704682554709 0.145968131210756 no 2975 0.0245889063383293 4685 5729214
SGTC_2029 5175081 200 µM -1.96914554823967 0.145743887151752 no 2976 0.0244681898299502 4640 1380876
SGTC_1529 apigenin 74 µM -1.97258293462954 0.145377110205775 no 2977 0.0242715494360609 4677 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2763 lisinopril 49.32 µM -1.97917089470455 0.144675896553616 no 2978 0.0238983843325195 4602 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1240 0356-0016 42.1 µM -1.97931091473074 0.144661017775985 no 2979 0.0238905057370643 4657 4305613
SGTC_3 0833-0587 95.581 µM -1.9844145304868 0.144119401876235 no 2980 0.0236048237502559 4582 5382644
SGTC_1077 5-fluorocytosine 377 nM -1.98829252827853 0.143708768753602 no 2981 0.0233896733311865 4703 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2507 purpurin 79.67 µM -1.98911327001557 0.143621963446303 no 2982 0.0233443509748572 4666 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_448 monastrol 171 µM -1.99186935195085 0.143330726909649 no 2983 0.0231926972287411 4613 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2311 7694451 200 µM -1.99790596881331 0.142694228799009 no 2984 0.0228634277124085 4677 2163142
SGTC_195 4234-0266 16.654 µM -2.00004133556735 0.142469534960302 no 2985 0.0227479002931951 4706 2303354
SGTC_3314 9135860 59.4275 µM -2.01196729214663 0.141219028799679 no 2986 0.0221116924783261 4672 25252478
SGTC_2415 st077333 57.7 µM -2.01854867619267 0.140532128119411 no 2987 0.0217670750274294 4660 2766255
SGTC_924 2046-0044 21.3 µM -2.01921524345051 0.140462685035833 no 2988 0.0217324263212093 4665 3623589
SGTC_2980 9014342 25.29 µM -2.02358121686744 0.140008413314023 no 2989 0.0215066296377068 4682 2996599
SGTC_1794 st048918 76.9 µM -2.02422608746509 0.139941400394209 no 2990 0.0214734472847656 4681 672303
SGTC_217 ketoconazole 989 nM -2.02443447917356 0.139919749645638 no 2991 0.0214627335724387 4518 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2748 diazoxide 86.69 µM -2.02630948079427 0.139725049712331 no 2992 0.0213665401582893 4750 3019 A potassium channel activatior.
SGTC_344 k064-0035 6.43 µM -2.02774142929523 0.139576480466439 no 2993 0.021293322471209 4633 5088750
SGTC_258 haloperidol 50.781 µM -2.03062919969741 0.13927719191657 no 2994 0.0211463116752478 4685 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_277 nystatin 15.5 µM -2.03072471759986 0.139267299906658 no 2995 0.0211414637506135 4707 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_433 pimozide 108 µM -2.04099861631055 0.138206106466618 no 2996 0.0206254823156781 4636 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1374 2889-5571 141 µM -2.04296246680181 0.138003889177198 no 2997 0.0205280768746782 4690 2853281
SGTC_2834 9001755 58.44 µM -2.0569902997386 0.13656531586506 no 2998 0.0198435794794569 4565 2989575
SGTC_363 0455-0021 3.06 µM -2.05914766882651 0.13634498793407 no 2999 0.0197400472597598 4627 4597466
SGTC_2898 9056270 58.44 µM -2.06100734877981 0.136155257693163 no 3000 0.0196511694993693 4715 19154699
SGTC_3039 9090270 49.47 µM -2.06241175631836 0.136012095545962 no 3001 0.0195842754907077 4677 17173750
SGTC_2004 4023728 41.89 µM -2.0683684458803 0.135406029681775 no 3002 0.0193026950051816 4655 360084 YDR527W RBA50
SGTC_3337 9144342 33.5465 µM -2.06916505675888 0.135325118706766 no 3003 0.0192653002692229 4690 17682949
SGTC_187 1488-2104 32.728 µM -2.06958716986527 0.135282258533598 no 3004 0.0192455102833703 4698 2852859
SGTC_1581 himbacine 57.9 µM -2.06975850243368 0.135264864563622 no 3005 0.0192374826066689 4708 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2544 sphondin 68.51 µM -2.07260978182702 0.134975622941146 no 3006 0.0191043049783607 4655 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3006 9075424 71.4286 µM -2.07944069378042 0.134284402979982 no 3007 0.0187884317448585 4668 7465181
SGTC_2429 5902844 64.44 µM -2.08457074150367 0.133766894531901 no 3008 0.0185541413240723 4697 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2997 9067075 71.4286 µM -2.08537167010896 0.133686222433693 no 3009 0.0185177881724311 4673 27209819
SGTC_84 0443-0269 128.823 µM -2.09080073216599 0.133140271748618 no 3010 0.0182729652297919 4684 6150058
SGTC_2591 skatole 100 µM -2.09283787525189 0.132935811514886 no 3011 0.0181818147551816 4673 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2975 9084847 53.72 µM -2.0929457772903 0.132924987832909 no 3012 0.0181769975826997 4671 27211724
SGTC_3231 9132313 49.47 µM -2.09563400019508 0.132655527328592 no 3013 0.0180573353506086 4699 4905967
SGTC_1315 1237-0019 3.69 µM -2.09638756986347 0.132580059025058 no 3014 0.0180239120788998 4700 825140
SGTC_1239 0337-0584 35.4 µM -2.09928537017224 0.132290126451603 no 3015 0.0178958761469099 4710 914301 YML130C ERO1
SGTC_1659 st012954 42.1 µM -2.09944822314448 0.132273845562444 no 3016 0.0178887037580028 4715 24207262
SGTC_1501 4491-0275 38.4 µM -2.10081169113701 0.132137589858836 no 3017 0.0178287498815952 4728 5104718
SGTC_2561 acetosyringone 100 µM -2.10312660332366 0.131906475000171 no 3018 0.0177273520084989 4667 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1359 1582-0056 520 nM -2.10361602155335 0.131857648475678 no 3019 0.0177059776188207 4737 3661189
SGTC_3129 9127257 49.47 µM -2.10367530130209 0.131851735312735 no 3020 0.0177033901847578 4656 837894
SGTC_2412 st077135 33.4 µM -2.10544470524107 0.131675321246624 no 3021 0.0176263078971352 4683 13258915
SGTC_1243 0416-0003 5.65 µM -2.11121447031588 0.131101192879421 no 3022 0.0173769408081508 4685 2141977
SGTC_491 tetrandrine 80.3 µM -2.11447255495574 0.130777757765905 no 3023 0.0172374632224429 4718 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1325 1431-0015 227 µM -2.11454850779078 0.130770224394667 no 3024 0.0172342231469492 4708 1103340
SGTC_2223 6903751 107.57 µM -2.12091100139742 0.130140226146186 no 3025 0.0169646463410274 4692 5598863
SGTC_625 k213-0058 121 µM -2.12144842636165 0.130087108028148 no 3026 0.0169420418417748 4740 3655420
SGTC_1074 carmofur 3.8 µM -2.12163145793692 0.130069020941849 no 3027 0.0169343492766893 4747 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3000 9075062 71.4286 µM -2.12862669587159 0.129379059266715 no 3028 0.0166425790082819 4700 17057871
SGTC_65 0798-0905 34.986 µM -2.12889533820393 0.129352612920343 no 3029 0.0166314602833384 4656 3602145
SGTC_117 lucigenin 22.078 µM -2.13156560052352 0.129089944102677 no 3030 0.0165212870930072 4665 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1690 st023502 41.2 µM -2.13329478426084 0.128920044878395 no 3031 0.0164502759084203 4734 24207482
SGTC_3329 9141233 27.5565 µM -2.13721186197623 0.12853575006704 no 3032 0.0162903818374783 4677 4909101 YNL103W MET4
SGTC_1269 0831-0796 3.05 µM -2.13902286095629 0.128358346466279 no 3033 0.016216908475104 4712 927758
SGTC_783 0848-0141 92.7 µM -2.1397220838497 0.128289896818385 no 3034 0.0161886166239548 4688 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_480 am 92016 50 µM -2.14121948982697 0.12814339519471 no 3035 0.0161281710262927 4714 2129 K+ channel blocker.
SGTC_2289 7946404 165.07 µM -2.14608051198573 0.127668608688205 no 3036 0.0159332778959417 4688 1246120 YPR165W RHO1
SGTC_1656 st012921 11 µM -2.14674642137389 0.127603663241407 no 3037 0.0159067374520022 4635 6732821
SGTC_118 0083-0097 135.343 µM -2.14739619737589 0.127540313411348 no 3038 0.0158808765664275 4677 5207356
SGTC_2847 9005661 71.43 µM -2.14791125308166 0.12749011365913 no 3039 0.0158604031290898 4734 2991449
SGTC_1362 1611-0397 101 µM -2.15040380135338 0.127247372318968 no 3040 0.0157616439617155 4726 27816
SGTC_765 1319-0117 244 µM -2.15142996470463 0.127147531030959 no 3041 0.0157211390950343 4695 3487746 YGL099W LSG1
SGTC_2121 5257820 149.641 µM -2.15182939490601 0.127108682929152 no 3042 0.0157053968890224 4719 791256
SGTC_3343 9148379 18.9835 µM -2.15328340772167 0.126967337148794 no 3043 0.0156482059928107 4728 1955036
SGTC_2586 curcumin 80 µM -2.15401850966091 0.126895918936885 no 3044 0.0156193601898268 4631 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_143 4032-1194 15.74 µM -2.15496033997464 0.126804457077257 no 3045 0.0155824689402209 4728 1806963
SGTC_2022 5136654 200 µM -2.16425698096721 0.125904115376834 no 3046 0.0152223161682251 4685 1713771
SGTC_186 3455-3465 67.277 µM -2.17517343473902 0.124852604209571 no 3047 0.014808561054806 4745 755278
SGTC_2954 9074818 52.69 µM -2.17787496803644 0.124593332911422 no 3048 0.0147076732977692 4705 16648742
SGTC_795 0685-0265 78 µM -2.18793973150492 0.12363071243546 no 3049 0.0143369963409646 4714 302754
SGTC_2797 7859098 81.82 µM -2.19063653264956 0.123373670311463 no 3050 0.0142390526293948 4676 972681
SGTC_2370 9071495 200 µM -2.19067169433613 0.123370321395107 no 3051 0.0142377794263795 4733 21791103
SGTC_1875 nocodazole 6 µM -2.19371583804265 0.123080628392028 no 3052 0.0141279222517555 4744 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2504 purpurogallin 52.29 µM -2.20357219298996 0.122145930398757 no 3053 0.0137772223310224 4695 5281571 An antioxidant.
SGTC_520 3584-0023 682 µM -2.2088413815134 0.121648292122079 no 3054 0.0135928378043279 4689 1340790
SGTC_770 0389-1121 67.2 µM -2.21239102442721 0.121313857255525 no 3055 0.0134698292625016 4740 6753108
SGTC_566 0958-0068 16.5 µM -2.21937537696797 0.120657704948789 no 3056 0.0132305986938367 4667 6815365
SGTC_1229 0139-0193 12.2 µM -2.22153595871719 0.12045523376978 no 3057 0.0131573409956107 4758 3090752
SGTC_3117 9124945 49.47 µM -2.22288579871471 0.120328859860923 no 3058 0.0131117508077398 4675 17592065
SGTC_1958 st076513 41.9 µM -2.22339146288211 0.120281542929546 no 3059 0.0130947074326394 4683 732122 YGL099W LSG1
SGTC_594 1487-1584 10.8 µM -2.2278263647488 0.119867113768677 no 3060 0.0129460480070359 4723 5013332
SGTC_3098 9119039 49.47 µM -2.2283663840514 0.11981671931471 no 3061 0.012928046424501 4723 17161528
SGTC_445 e6 berbamine 66 µM -2.2325908856274 0.119423005474039 no 3062 0.0127879678495179 4722 6610268 A calcium/calmodulin antagonist.
SGTC_2697 mebhydrolin 72.4 µM -2.24251149383199 0.118502018841242 no 3063 0.0124641666509019 4712 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1930 st074634 34.3 µM -2.24351625635101 0.11840902171912 no 3064 0.012431771378212 4672 684253 YOR116C RPO31
SGTC_3271 9137798 49.47 µM -2.25359306493068 0.11747920177023 no 3065 0.012110890012169 4732 6498326
SGTC_1343 1487-0095 224 µM -2.25727391051132 0.117140850668269 no 3066 0.0119954822693453 4721 4560101 YGL055W OLE1
SGTC_1462 k081-0014 26.5 µM -2.25939950672656 0.116945776120354 no 3067 0.0119292725342603 4205 3270634
SGTC_3183 9108214 49.47 µM -2.26302958515352 0.116613161713891 no 3068 0.01181693279726 4755 4974831
SGTC_857 0438-0306 1.35 µM -2.26648372392366 0.116297291579224 no 3069 0.0117108912893092 4754 4686136
SGTC_2282 7944268 200 µM -2.26947572919484 0.116024173177214 no 3070 0.0116197057710702 4708 2970414
SGTC_2371 9071574 200 µM -2.27065539971414 0.1159166148836 no 3071 0.0115839234720021 4747 45596039
SGTC_1014 4130-3005 69.3 µM -2.27203729113747 0.115790708847835 no 3072 0.0115421290400559 4725 743608
SGTC_825 1988-2224 89.6 µM -2.27640174652942 0.115393695144811 no 3073 0.0114109876228418 4729 1180859
SGTC_1497 4476-2978 41.3 µM -2.27912851374089 0.115146145671977 no 3074 0.0113297134909383 4759 1528379
SGTC_359 0081-0058 15.9 µM -2.2839051276947 0.114713411421818 no 3075 0.0111885536093944 4700 3494159
SGTC_3095 9117207 49.47 µM -2.28828551435587 0.114317591411534 no 3076 0.011060449765492 4736 17015229
SGTC_597 k018-0003 82.8 µM -2.29062203075909 0.114106857533163 no 3077 0.010992641809991 4769 6786234
SGTC_42 0133-0086 60.653 µM -2.29867071812263 0.113383053244615 no 3078 0.0107618222488188 4678 162923 Model of phenazepam hydroxylation.
SGTC_1935 st074532 41.6 µM -2.29936762755023 0.113320535798027 no 3079 0.0107420362920641 4722 2829742
SGTC_1396 3511-0007 98.6 µM -2.31594495514203 0.111840681352184 no 3080 0.0102806371690926 4741 X1396
SGTC_1093 fluphenazine 7.97 µM -2.31641560655582 0.111798869127776 no 3081 0.0102677937225793 4759 6602611 An atypical antipsychotic.
SGTC_2126 5251174 33.877 µM -2.31681157321352 0.111763700486977 no 3082 0.0102569991632339 4710 790722
SGTC_803 4488-1585 147 µM -2.3169542047093 0.111751034298916 no 3083 0.0102531132708336 4739 747204
SGTC_3204 9114183 49.47 µM -2.32553325987046 0.110991070754179 no 3084 0.0100217317955051 4689 17027248
SGTC_2863 9028737 58.44 µM -2.3463681183042 0.109160873179823 no 3085 0.00947868689286065 4747 6460917
SGTC_2491 paeonol 100 µM -2.355649506622 0.108352587679005 no 3086 0.00924517735675187 4743 11092 Increases levels of cortical cytochrome oxidase.
SGTC_256 clotrimazole 625 nM -2.3568850137204 0.108245317102995 no 3087 0.00921447618485437 4703 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2179 6298986 200 µM -2.35727327226575 0.108211623075748 no 3088 0.00920484677517312 4732 738374
SGTC_969 1313-0238 134 µM -2.36645288860535 0.107417191602927 no 3089 0.00897972991948773 4756 5212874
SGTC_1057 3448-5381 134 µM -2.37495570712701 0.106685090496536 no 3090 0.00877552807690567 4729 5497911
SGTC_805 3852-0218 479 µM -2.37699778826774 0.106509802831187 no 3091 0.00872709639158202 4748 6615355
SGTC_2065 5221596 34.26 µM -2.37848895523882 0.106381935816839 no 3092 0.00869187884568288 4720 788581
SGTC_2606 farnesol 9.78 µM -2.38168295826825 0.106108424321739 no 3093 0.00861686376672187 4725 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1919 st067113 52.3 µM -2.38848722479613 0.105527450502543 no 3094 0.00845894824939173 4704 1268243
SGTC_284 0988-0104 32.6 µM -2.39261852246396 0.105175829128114 no 3095 0.00836431204238362 4735 4666532
SGTC_565 1418-0001 44.5 µM -2.39885788821417 0.104646395071428 no 3096 0.00822314806229252 4756 2862145
SGTC_418 lividomycin a 100 µM -2.39952417638507 0.104589972249983 no 3097 0.00820819785723406 4757 72394 An antibiotic.
SGTC_1641 st009299 47.1 µM -2.40625639621694 0.104021108211229 no 3098 0.00805847442194463 4761 4046054
SGTC_393 acivicin 6.25 µM -2.41436211842 0.103339165925496 no 3099 0.00788139385462178 4663 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -2.41970273793394 0.102891631668483 no 3100 0.00776659961778744 4774 165521
SGTC_2771 fluoxetine 41.05 µM -2.4217838058909 0.102717623747034 no 3101 0.00772226792512236 4744 3386 A selective serotonin reuptake inhibitor.
SGTC_2107 5363541 170.161 µM -2.42262869727484 0.102647039462517 no 3102 0.00770433339111523 4727 244052
SGTC_127 0180-0333 59.125 µM -2.43749812283531 0.101410576518622 no 3103 0.00739464550400561 4706 771601
SGTC_123 0083-0120 66.675 µM -2.43831289667503 0.101343139129625 no 3104 0.00737799766291581 4739 16001701
SGTC_1844 rapamycin 4 nM -2.43982649633251 0.101217947895487 no 3105 0.00734715874629586 4615 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_226 1,3-diallylurea 8.28947 mM -2.45157569924724 0.100249991191041 no 3106 0.00711161330082931 4759 74537 YKL182W FAS1
SGTC_600 1495-0418 41.6 µM -2.45351147455327 0.100091163051192 no 3107 0.00707345129430213 4758 5377768
SGTC_2766 oltipraz 83.91 µM -2.45379297500889 0.100068081571867 no 3108 0.00706791685129854 4753 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1499 4480-0877 67.3 µM -2.46221110236379 0.0993796365445852 no 3109 0.00690416830112808 4773 2861909
SGTC_1033 k072-0102 21.3 µM -2.46558203983837 0.0991049300697476 no 3110 0.00683954229650504 4734 5965931
SGTC_25 0118-0223 35.662 µM -2.47258115720629 0.0985363282544025 no 3111 0.00670706262263446 4743 5333628
SGTC_2382 9035899 200 µM -2.47613220211135 0.0982487595722516 no 3112 0.00664071945056464 4754 6462679
SGTC_1830 st055982 50.3 µM -2.47699620482212 0.0981788844724544 no 3113 0.00662466554101149 4740 455313 An antimicrobial agent.
SGTC_2192 5915882 198.485 µM -2.49028533520212 0.0971087257168528 no 3114 0.00638202878933806 4767 2876149
SGTC_457 grayanotoxin iii 135 µM -2.5030614499449 0.0960879752098307 no 3115 0.00615620822610372 4618 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3166 9102297 49.47 µM -2.50334726362247 0.0960652306233211 no 3116 0.00615123839637217 4756 25237072
SGTC_268 camptothecin 39.6153 µM -2.50340700176954 0.0960604772591593 no 3117 0.00615020009744293 4724 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2347 9049783 174.81 µM -2.5094279584689 0.0955822764203978 no 3118 0.00604634396506531 4750 6467988 YPL169C MEX67
SGTC_679 0422-0091 41.4 µM -2.51526705929892 0.0951201945474336 no 3119 0.00594711240526883 4770 627384 YHR062C RPP1
SGTC_102 gallobenzophenone 83.616 µM -2.52268636688714 0.094535437782125 no 3120 0.00582311099969407 4755 70837
SGTC_1406 3909-7906 11.9 µM -2.52283806697827 0.0945235091669985 no 3121 0.00582059969514836 4770 X1406
SGTC_838 0109-0203 71.4 µM -2.5238697213485 0.0944424166447921 no 3122 0.00580354674454638 4772 759422
SGTC_3205 9113483 49.47 µM -2.52652808427256 0.0942336941688631 no 3123 0.00575980888532336 4724 17018033
SGTC_1081 sertraline 6 µM -2.54218346371341 0.0930114039063065 no 3124 0.0055081166325869 4754 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1547 harmine 94.2 µM -2.54840763581882 0.0925287226718324 no 3125 0.00541079694481616 4705 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2612 dictamnine 15.46 µM -2.55771731144193 0.0918102248153574 no 3126 0.00526808518581514 4718 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1803 st050068 52.4 µM -2.55830509255978 0.0917650004047141 no 3127 0.0052591882625017 4762 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1829 berberine 14.4 µM -2.56436159502117 0.0912999683634756 no 3128 0.0051682897645294 4725 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_659 k018-0002 107 µM -2.5693270132779 0.0909200174900842 no 3129 0.00509481256253364 4760 6797879 YHR007C ERG11
SGTC_978 1416-0512 87.4 µM -2.57225570136944 0.0906964666908173 no 3130 0.00505191181626517 4767 6814003
SGTC_995 3931-2021 34.6 µM -2.57236638859917 0.0906880257893825 no 3131 0.00505029674693052 4752 730143
SGTC_2702 st077768 96.8 µM -2.58573566706022 0.0896727805379257 no 3132 0.0048585709606747 4765 6484119
SGTC_2373 9071805 200 µM -2.58720824882727 0.0895614733421358 no 3133 0.00483785476426326 4766 10149009
SGTC_1760 st045453 10.4495 µM -2.59154640200212 0.0892341650354603 no 3134 0.00477728278035972 4765 3323419 YIL048W NEO1
SGTC_2128 5255449 168.493 µM -2.59300261074522 0.0891244956448689 no 3135 0.0047571024174182 4727 736008
SGTC_1022 4477-0945 21.3 µM -2.59351533343269 0.0890859055718289 no 3136 0.00475001514463218 4736 4648966
SGTC_1773 st048542 73.5835 µM -2.59778356412217 0.0887651397333863 no 3137 0.0046913806919619 4761 3237138
SGTC_2229 7354935 190 µM -2.59801109931049 0.0887480641994971 no 3138 0.004688273152925 4763 318112
SGTC_1711 st032263 62.8 µM -2.59994095165359 0.0886033354564102 no 3139 0.00466199013716187 4777 3958979
SGTC_2047 4141938 200 µM -2.60030169683195 0.08857630098573 no 3140 0.00465709169181019 4781 3807862
SGTC_1232 0279-0259 161 µM -2.60501849459224 0.0882233864104775 no 3141 0.00459346503975815 4764 1560000
SGTC_2246 7293507 91.5585 µM -2.60587041783036 0.0881597567323371 no 3142 0.00458205620925249 4767 887656
SGTC_2096 5468907 200 µM -2.6116634263348 0.0877279870854757 no 3143 0.004505145571668 4776 759785
SGTC_2159 5658611 73.75 µM -2.62294328422003 0.0868917963434569 no 3144 0.00435868914126859 4765 793844
SGTC_439 amiodarone 34.4 µM -2.63255407387214 0.0861840460648345 no 3145 0.00423727658510313 4695 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2456 5770359 74.46 µM -2.64700944139968 0.0851276684217968 no 3146 0.00406035428633914 4762 3118787
SGTC_2337 9009472 200 µM -2.64987691396012 0.0849192758324876 no 3147 0.00402605501279846 4725 5742383
SGTC_570 0987-0065 62.6 µM -2.65138690195747 0.0848096918037604 no 3148 0.00400809775684713 4746 3104428
SGTC_1295 1013-0063 9.78 µM -2.65624102745842 0.0844581327078326 no 3149 0.00395085578740527 4790 6826038
SGTC_2877 9040724 71.43 µM -2.66466534648856 0.0838506001265544 no 3150 0.00385324853634947 4749 6463895
SGTC_280 3448-3607 3.04 µM -2.66536028805557 0.083800630283935 no 3151 0.00384529399744388 4760 626179
SGTC_1109 tnp00067 928.257 nM -2.66933548552323 0.0835152231460349 no 3152 0.00380007475013759 4774 676295
SGTC_769 0302-0231 76 µM -2.6746899609891 0.0831319434675375 no 3153 0.00373991937320747 4732 571869 YER009W NTF2
SGTC_2941 9056145 11.23 µM -2.67737436256789 0.0829402893394143 no 3154 0.00371008377182651 4763 2119517
SGTC_183 3914-0051 30.55 µM -2.67993867513743 0.0827575196065318 no 3155 0.00368178245022297 4764 1596232
SGTC_2195 6536160 144.242 µM -2.68261727178269 0.0825669281500808 no 3156 0.00365242677685197 4788 3834386
SGTC_1679 SEC14.276 6.7 µM -2.68924201589665 0.0820969738814523 no 3157 0.00358072390286867 4739 1005053 YMR079W SEC14
SGTC_310 1273-0058 1.06 µM -2.70319207541708 0.0811139608940505 no 3158 0.00343385238477528 4458 2734232
SGTC_699 0375-0592 111 µM -2.70464222544232 0.0810122856272771 no 3159 0.00341889955839737 4796 762578
SGTC_1855 st056195 39.6 µM -2.71095523831536 0.0805707781095426 no 3160 0.00335448412114941 4742 4028379
SGTC_1949 st076024 69.1 µM -2.71177310644151 0.0805137128383463 no 3161 0.00334621924360652 4751 2921930
SGTC_3125 9127534 49.47 µM -2.71290995980187 0.0804344416719326 no 3162 0.00333476130259488 4761 1639235
SGTC_350 k064-0020 19.8 µM -2.71316026254631 0.0804169963412004 no 3163 0.00333224333292779 4768 2790705
SGTC_2584 androsterone 48.74 µM -2.73098493460257 0.0791820085417289 no 3164 0.00315726790568997 4715 2754130 A steroid.
SGTC_2442 5158906 48.48 µM -2.73195041028662 0.0791155275481676 no 3165 0.00314803083498925 4767 1893835
SGTC_177 1327-0068 8.361 µM -2.74656102429885 0.0781146188811632 no 3166 0.00301118405579121 4783 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2048 5246248 200 µM -2.74887403524132 0.0779570493263231 no 3167 0.00299001813225128 4783 677046
SGTC_2595 hexamethylquercetagetin 100 µM -2.75097433352145 0.0778141794569135 no 3168 0.00297091493312065 4747 386331
SGTC_701 4424-0219 185 µM -2.75828775103643 0.0773182449383168 no 3169 0.00290525124930696 4781 2911779
SGTC_1807 st050092 58.9 µM -2.7607474365991 0.0771519904078277 no 3170 0.00288346272856299 4783 5008496
SGTC_3093 9117344 49.47 µM -2.76106253041082 0.0771307122982679 no 3171 0.00288068222029913 4784 24824913
SGTC_221 trifluoperazine 10.304 µM -2.77496677963003 0.0761961995576388 no 3172 0.00276036733670341 4756 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_525 k781-2675 26.7 µM -2.77986112095964 0.07586930671524 no 3173 0.00271910752151127 4755 3651118 YDL195W SEC31
SGTC_1990 st072050 59.8 µM -2.78502327836549 0.0755256848696452 no 3174 0.0026761940186526 4788 17233948
SGTC_1310 1188-0297 994 nM -2.78968335075813 0.0752165042535993 no 3175 0.0026379806811567 4740 1588352
SGTC_1340 1486-1359 257 µM -2.80652568320972 0.0741071131449449 no 3176 0.00250394600765123 4772 4309068
SGTC_2119 5528445 120.635 µM -2.80808738912119 0.0740048814059976 no 3177 0.00249183504304825 4782 791935
SGTC_164 4100-3994 89.624 µM -2.81809765375242 0.0733521507935049 no 3178 0.00241545573110566 4755 4615967
SGTC_2329 6138490 200 µM -2.81989430960027 0.0732354653585348 no 3179 0.00240197345984571 4755 720019
SGTC_871 0574-0004 149 µM -2.83483805847645 0.0722704262878353 no 3180 0.00229244601784435 4759 9551173
SGTC_1273 0849-0096 14.1 µM -2.84994673096116 0.0713046743834718 no 3181 0.00218632758838077 4785 5286025
SGTC_2389 9091542 195.52 µM -2.85828129016808 0.0707761828470719 no 3182 0.0021297131149838 4772 3626624 YOL127W RPL25
SGTC_1694 st024011 44.9 µM -2.86008034298171 0.0706625014638845 no 3183 0.00211766846526989 4797 2787533
SGTC_3336 9143619 71.43 µM -2.86226771649905 0.0705244713500684 no 3184 0.00210310725326887 4773 45595730
SGTC_184 1494-0393 24.714 µM -2.86898342256709 0.070101984133085 no 3185 0.00205896690380074 4765 3090647
SGTC_1558 st069300 45.6 µM -2.86920185092426 0.0700882754994439 no 3186 0.00205754545976987 4787 24208000
SGTC_1347 1493-0251 600 nM -2.86923082031711 0.0700864575259745 no 3187 0.00205735700549395 4792 3986378
SGTC_3050 9093513 49.47 µM -2.87105158411767 0.0699722683163394 no 3188 0.00204554379346136 4769 25236664
SGTC_37 0566-0070 1.56 µM -2.87260345830727 0.069875055565645 no 3189 0.00203552378267337 4768 1626686
SGTC_1920 st075728 45.7 µM -2.8726363791683 0.069872994458203 no 3190 0.00203531170540575 4773 3400306
SGTC_730 1436-0052 41.2 µM -2.89701425334403 0.0683595518538594 no 3191 0.00188366319429513 4790 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3042 9091578 49.47 µM -2.9053849631595 0.0678457510111848 no 3192 0.0018340082731739 4762 25236497
SGTC_2475 5812728 15.03 µM -2.90874217246135 0.0676405227719654 no 3193 0.00181442998873545 4768 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2291 7917025 104.35 µM -2.9184716685418 0.0670484615867247 no 3194 0.00175875919022877 4748 2964612
SGTC_72 0744-0168 198.391 µM -2.93236520248336 0.0662099677146152 no 3195 0.00168195458748782 4749 677577
SGTC_203 k066-0004 30.888 µM -2.9381602453073 0.0658626385791666 no 3196 0.00165083160167994 4793 6795412
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -2.93900834648553 0.0658119258302815 no 3197 0.00164632103495068 4789 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_115 0527-0192 112.043 µM -2.93970401160283 0.0657703506911937 no 3198 0.00164262957275543 4765 4233931
SGTC_2626 ethyl orsellinate 100 µM -2.9403541251206 0.0657315162643205 no 3199 0.00163918664180065 4764 75653 A natural product.
SGTC_348 k064-0012 10.7 µM -2.94702676093671 0.0653339542393984 no 3200 0.00160422717808718 4785 5066323
SGTC_1514 1189-1591 158 µM -2.95196162699155 0.0650411319890713 no 3201 0.00157881084279592 4783 767698 YMR146C TIF34
SGTC_3287 9117173 37.0625 µM -2.96253571395248 0.064417123422074 no 3202 0.00152558205566176 4795 2789709
SGTC_2891 9063876 19.48 µM -2.96413143232702 0.0643233606071069 no 3203 0.0015176930613356 4794 6472478
SGTC_1495 4469-0029 237 µM -2.97496585758244 0.0636895427630778 no 3204 0.00146510579553293 4790 793680
SGTC_202 3594-0513 34.79 µM -2.98922939036526 0.0628625426838685 no 3205 0.00139841035064705 4800 708429
SGTC_322 k048-0136 19.3 µM -2.99029862678637 0.0628008870078491 no 3206 0.00139352413807108 4800 6823282
SGTC_3044 9093193 49.47 µM -2.99467613487266 0.0625489567902609 no 3207 0.00137368191059471 4764 25236277
SGTC_1143 3454-2408 5.08 µM -2.99613150974275 0.0624653731634654 no 3208 0.00136714242223372 4785 X1143
SGTC_3086 9117350 49.47 µM -3.00710451403954 0.0618379832637657 no 3209 0.00131874533230597 4793 2679265
SGTC_1044 1222-0021 1.78 µM -3.01532850986513 0.0613710029587374 no 3210 0.00128350528158027 4756 4306703
SGTC_514 4466-0038 2.65 nM -3.04966177951553 0.0594511668784181 no 3211 0.00114549603542026 4714 5722064
SGTC_810 3825-7150 143 µM -3.05551474957929 0.0591286306676765 no 3212 0.00112337275872613 4786 22330411 YGL099W LSG1
SGTC_2363 9053361 176 µM -3.06777992889679 0.0584571931322579 no 3213 0.00107827685955476 4785 6469797 YMR079W SEC14
SGTC_2640 pentamidine 10.38 µM -3.06817254788467 0.0584357991466252 no 3214 0.00107686110581678 4781 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2964 9083345 53.42 µM -3.08004590171654 0.0577917147359285 no 3215 0.00103484347406131 4774 17741579
SGTC_422 cantharidin 155 µM -3.08078406248213 0.0577518573340371 no 3216 0.00103228158456948 4768 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_602 3130-1533 38.1 µM -3.08555541237309 0.0574947467760125 no 3217 0.00101586181188279 4797 720941
SGTC_3228 9131799 49.47 µM -3.09278985350664 0.0571066278941715 no 3218 0.00099142245769224 4801 17015818
SGTC_2967 9089538 49.85 µM -3.09348459900944 0.0570694644520773 no 3219 0.000989104101760499 4776 728216
SGTC_1851 st056236 18.9 µM -3.09374897160649 0.0570553275910933 no 3220 0.00098822320201417 4784 5393171
SGTC_1827 berberine 7.24 µM -3.0990447191887 0.0567727270931894 no 3221 0.00097072856768398 4766 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2659 sanguinarine 24.21 µM -3.10194236328677 0.0566185655110778 no 3222 0.000961276933214715 4790 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3047 9092122 49.47 µM -3.10702939931239 0.0563487210091672 no 3223 0.00094488801949428 4775 17173831
SGTC_2800 7887935 81.82 µM -3.1139172698704 0.0559849670845794 no 3224 0.000923106242853466 4785 2961002
SGTC_791 1348-1292 225 µM -3.11876869718837 0.0557298729221753 no 3225 0.000908042338415937 4792 5437054
SGTC_2359 9039622 200 µM -3.13480430220259 0.054893222314985 no 3226 0.000859843957239601 4784 6463596
SGTC_2759 disulfiram 3.38 µM -3.13793938665039 0.0547308167107822 no 3227 0.000850700282981429 4759 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_576 1073-0113 22.7 µM -3.13845825632926 0.0547039745729602 no 3228 0.000849195620819864 4797 5439563
SGTC_2700 st077718 96.8 µM -3.23594792477866 0.049842615524918 no 3229 0.000606197501158009 4787 904970
SGTC_759 3486-0358 89.3 µM -3.26744560419822 0.0483477864692351 no 3230 0.000542613594967477 4799 875103
SGTC_255 tunicamycin 200.472 nM -3.2739851522892 0.0480419712908889 no 3231 0.000530210915356375 4778 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1740 st038286 13.222 µM -3.27572364562039 0.0479609334744949 no 3232 0.000526958164226553 4786 716786
SGTC_2226 7298446 200 µM -3.27648888846121 0.0479252972804249 no 3233 0.000525532241986718 4789 3283010
SGTC_2916 7875993 68.79 µM -3.28436238434655 0.0475598702475599 no 3234 0.000511067010399213 4787 1299250
SGTC_1140 3229-1848 2.98 µM -3.28449553781949 0.0475537095352124 no 3235 0.000510825579730069 4788 2849525
SGTC_171 k064-0041 9.68 µM -3.30501258744276 0.0466120440042838 no 3236 0.000474860672703812 4780 53325
SGTC_441 propafenone 146 µM -3.31615432450314 0.046106978569136 no 3237 0.000456327078189393 4793 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3049 9092223 49.47 µM -3.31829692038799 0.046010358461914 no 3238 0.000452840768195797 4788 8623917
SGTC_1142 3253-1408 9.78 µM -3.32158317911882 0.0458624811496085 no 3239 0.000447541493070912 4784 256655
SGTC_778 3456-2434 196 µM -3.34023487199613 0.0450304005312234 no 3240 0.000418537819054788 4781 5539063
SGTC_3230 9131665 49.47 µM -3.34454023158635 0.0448400682684014 no 3241 0.000412095374925144 4805 15943720
SGTC_2167 5876490 200 µM -3.34763642554653 0.0447035918685518 no 3242 0.000407519303467757 4785 686534
SGTC_130 0136-0219 337.655 µM -3.35775757832825 0.0442597966057559 no 3243 0.000392887471463933 4783 234244
SGTC_2089 5281248 129.67 µM -3.36578050526865 0.0439105339171514 no 3244 0.000381637088839674 4800 2737878
SGTC_2157 5649910 96.377 µM -3.39069030805589 0.0428402788420842 no 3245 0.000348584162391899 4791 2858091
SGTC_2570 licareol 100 µM -3.40972605589597 0.042036696957458 no 3246 0.000325140808616852 4788 443158
SGTC_398 bronopol 33.3 µM -3.41259890157505 0.0419164881197029 no 3247 0.000321732866107427 4785 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1568 digitonin 820 nM -3.41414200343667 0.0418520349001334 no 3248 0.000319916090172217 4790 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_299 1273-0059 1.44 µM -3.41828591053918 0.0416793467087416 no 3249 0.000315084360238366 4682 2848077
SGTC_2875 9039966 71.43 µM -3.42192061041054 0.0415283541518479 no 3250 0.000310902333397477 4799 6463691
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -3.43329294164212 0.0410587859070363 no 3251 0.00029814872962652 4790 279621
SGTC_667 1498-1044 59 µM -3.4362258052809 0.0409383877373869 no 3252 0.000294939554495073 4797 6739982
SGTC_1962 st076595 64.5 µM -3.44173432792525 0.0407130292724718 no 3253 0.000288998807100909 4787 279619
SGTC_2120 5538279 151.968 µM -3.45809904982455 0.0400494665395321 no 3254 0.000272000670533008 4807 2058197
SGTC_2259 7964009 200 µM -3.47350882331933 0.0394326850621673 no 3255 0.000256850236472901 4800 313134
SGTC_3056 9094900 49.47 µM -3.48145059862808 0.0391178431778437 no 3256 0.000249352882399084 4801 25236784
SGTC_2761 levamisole 97.89 µM -3.48292026190914 0.0390598051708226 no 3257 0.000247988033977928 4799 26879 An alkaline phosphatase inhibitor.
SGTC_190 3970-0790 3.722 µM -3.52050555965752 0.0375992042384758 no 3258 0.00021536248153416 4805 2832352
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -3.52062710407093 0.037594554260851 no 3259 0.000215263799506163 4776 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1725 st036284 20.55 µM -3.54433379986917 0.036696533891803 no 3260 0.000196803287348265 4799 707914
SGTC_567 1080-0542 68.4 µM -3.58380340845733 0.0352403827726664 no 3261 0.000169313497602652 4797 5950415
SGTC_2374 9071832 200 µM -3.59978741899812 0.0346643290399494 no 3262 0.000159238718668689 4803 17381698
SGTC_1385 3091-4834 14.1 µM -3.60185126632817 0.0345905162147832 no 3263 0.000157979563774426 4796 4072814
SGTC_104 0074-0074 590.992 µM -3.60208695926981 0.0345820949535132 no 3264 0.000157836361821548 4798 3943124
SGTC_628 1636-0253 16 µM -3.60988139412026 0.0343045487242464 no 3265 0.000153168522992528 4804 4456143
SGTC_3034 9090421 49.47 µM -3.61754881524172 0.034033314063336 no 3266 0.000148703125719817 4789 17173761
SGTC_3010 9080089 71.4286 µM -3.6296943701572 0.0336072767923544 no 3267 0.000141878497727221 4804 17027233
SGTC_951 1171-0579 82.7 µM -3.64050332059698 0.0332318251122792 no 3268 0.000136052799087507 4776 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1096 rimcazole 32.2 µM -3.65315098322047 0.0327968987575085 no 3269 0.000129520904690601 4806 18528119 A dopamine reuptake inhibitor.
SGTC_896 0964-0007 44.5 µM -3.667876159263 0.0322964545106285 no 3270 0.000122286792460487 4789 6756758
SGTC_2309 7664088 163.95 µM -3.6721207031846 0.0321533767614925 no 3271 0.000120273007052942 4791 704922
SGTC_3083 9117465 49.47 µM -3.69047306950227 0.0315407533231889 no 3272 0.000111918693278472 4799 16420915
SGTC_1063 disulfiram 1.84 µM -3.70161359263646 0.0311735982094826 no 3273 0.000107116353476927 4801 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_608 k048-0125 159 µM -3.70433356009906 0.0310844959761806 no 3274 0.000105973607715999 4807 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1718 roemerine 11.9335 µM -3.72204999833678 0.0305092733385356 no 3275 9.88059400984633e-05 4655 235224 An aporphine alkaloid with mutagenic activity.
SGTC_273 hydroxyurea 18.1 mM -3.74993385516244 0.0296218110525037 no 3276 8.84406104776391e-05 4808 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1293 1000-1278 195 µM -3.76169678226103 0.029253910457019 no 3277 8.43822837002542e-05 4806 678847
SGTC_135 0933-0004 26.348 µM -3.76414037782814 0.0291779619098049 no 3278 8.35614933428722e-05 4796 21230617 YGL099W LSG1
SGTC_2709 st078560 56 µM -3.77312537597737 0.0289001093515175 no 3279 8.06076103034996e-05 4801 17250903
SGTC_444 curcumin 90.4 µM -3.77465777730498 0.0288529415253696 no 3280 8.01137362636962e-05 4782 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_197 4544-0043 41.561 µM -3.78855415444515 0.0284281209450069 no 3281 7.57632827759612e-05 4806 896523
SGTC_2879 9041815 71.43 µM -3.80107662776045 0.028049771808711 no 3282 7.20343679117931e-05 4802 4942971
SGTC_1255 0566-0045 221 µM -3.81452211418102 0.0276482127672262 no 3283 6.8223359344403e-05 4801 2788469
SGTC_2828 7998861 71.43 µM -3.81720160132881 0.0275687632437271 no 3284 6.74869393237325e-05 4806 2988188
SGTC_324 1315-0088 19.6 µM -3.86270145257492 0.0262484448057683 no 3285 5.60700110424e-05 4810 6787421
SGTC_1476 4112-3294 3.34 µM -3.86550145149154 0.0261689510958126 no 3286 5.54305948311883e-05 4806 704369
SGTC_1094 duloxetine 25.4 µM -3.8828963954247 0.0256795955294731 no 3287 5.16097777358201e-05 4808 60834 A selective serotonin reuptake inhibitor.
SGTC_3296 9122258 64.045 µM -3.91029003287039 0.0249244992085904 no 3288 4.60926819121117e-05 4802 4730474
SGTC_2057 5236571 38.335 µM -3.93075295921782 0.0243726709614245 no 3289 4.23401235800443e-05 4802 54684039 YBR257W POP4
SGTC_619 1652-1634 108 µM -3.93927417544954 0.0241459215916211 no 3290 4.08642445566447e-05 4799 5400454
SGTC_3232 9132874 49.47 µM -3.94083306958072 0.0241046317907231 no 3291 4.05995599639495e-05 4805 3784940
SGTC_2459 5811157 9.22 µM -3.95657515250968 0.0236909915454052 no 3292 3.8015988056085e-05 4808 2870684 YBR192W RIM2
SGTC_2791 5663188 71.43 µM -3.96003496534778 0.0236008857547297 no 3293 3.74693951115565e-05 4800 54690634
SGTC_590 k048-0076 22.4 µM -3.97647311690493 0.0231767066689654 no 3294 3.49724509394207e-05 4808 6832814
SGTC_3218 9131285 49.47 µM -3.99766680381558 0.0226393020189997 no 3295 3.19849553545932e-05 4792 17156417
SGTC_2046 4110841 106 µM -4.02513384061716 0.0219584874369631 no 3296 2.84714597925024e-05 4808 44119630 YMR134W ERG29
SGTC_1619 st003326 88.7 µM -4.07215280692609 0.0208331737149251 no 3297 2.32903013770278e-05 4798 2849032
SGTC_2740 felodipine 17.08 µM -4.10964328156503 0.0199712508679899 no 3298 1.98135389399262e-05 4807 3333 L-type calcium channel blocker
SGTC_3105 9121040 49.47 µM -4.11396238644862 0.0198739243199806 no 3299 1.94462417530551e-05 4807 41448907
SGTC_782 0083-0095 30.5 µM -4.11585823736818 0.0198313305675606 no 3300 1.92870676254591e-05 4806 3591729 An indicator and reagent.
SGTC_3118 9124250 49.47 µM -4.12790260501633 0.019562537521954 no 3301 1.8304355027946e-05 4806 1504786
SGTC_3107 9121808 49.47 µM -4.13283938886605 0.0194532611690705 no 3302 1.79154558513506e-05 4802 662681
SGTC_189 3970-0742 2.116 µM -4.1462924236177 0.0191581050803822 no 3303 1.68951114792434e-05 4809 2891807
SGTC_2747 doxorubicin 7.63 µM -4.15509493826159 0.0189670477458559 no 3304 1.62576251475856e-05 4809 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3128 9127691 49.47 µM -4.20215531248557 0.0179728816292074 no 3305 1.32192816587899e-05 4803 41316314
SGTC_1522 st012842 45.6 µM -4.25106035164956 0.0169871730523771 no 3306 1.06380410893523e-05 4794 3491067 YOR116C RPO31
SGTC_2139 5578692 56.4705 µM -4.25308556182466 0.0169473704826716 no 3307 1.05422484149633e-05 4807 650991 YMR113W FOL3
SGTC_3149 9097855 49.47 µM -4.28072610258605 0.0164120568239419 no 3308 9.31422576225266e-06 4802 25236625 YMR079W SEC14
SGTC_402 epigallocatechin gallate 10 µM -4.29437619049295 0.0161530800392268 no 3309 8.75926050140941e-06 4807 65064 An antioxidant.
SGTC_55 0767-0285 6.563 µM -4.34694171484782 0.0151882270761636 no 3310 6.90244420945201e-06 4806 3116166
SGTC_3190 9110366 49.47 µM -4.3525171111589 0.0150888548168861 no 3311 6.72916821727618e-06 4805 17123768
SGTC_3240 9133527 49.47 µM -4.35784365717173 0.0149944402776582 no 3312 6.56750776264048e-06 4809 17617455
SGTC_3219 9131112 49.47 µM -4.46183475906131 0.0132503507920478 no 3313 4.06304391812655e-06 4792 17612988 YMR079W SEC14
SGTC_2471 5466956 24.79 µM -4.46383822450204 0.0132185473774057 no 3314 4.02521783805054e-06 4809 724419
SGTC_788 1182-0090 188 µM -4.49048720607363 0.0128017486099995 no 3315 3.55302217798165e-06 4800 5715185
SGTC_1265 0819-1001 68.8 µM -4.50212943228823 0.0126232588667856 no 3316 3.3637994116918e-06 4802 3106768
SGTC_558 k064-0027 21.3 µM -4.6799679788769 0.0101528902763008 no 3317 1.43459862848189e-06 4809 5088526
SGTC_211 3455-0679 143.504 µM -4.94502678186207 0.0072543575738078 no 3318 3.80666984492533e-07 4767 748649
SGTC_829 1635-0120 117 µM -4.95348157074796 0.00717534682057726 no 3319 3.64486326703493e-07 4808 285054
SGTC_2364 9055074 200 µM -4.96074330919307 0.0071080921785914 no 3320 3.51119698035998e-07 4808 6470630
SGTC_2866 9034245 58.44 µM -4.97791254419828 0.00695128672474766 no 3321 3.21368418861072e-07 4809 6462273
SGTC_1450 4112-4260 37.6 µM -5.12444709742795 0.00573255829229366 no 3322 1.49206059053379e-07 4806 1633175
SGTC_1208 2323-2347 50.3 µM -5.12579371358787 0.00572229907166394 no 3323 1.48143437258234e-07 4809 5412760
SGTC_2011 4012611 177 µM -5.15423776008283 0.00550937189538852 no 3324 1.27332331869464e-07 4807 2049887
SGTC_2177 5811945 192 µM -5.19808724815187 0.00519490020257647 no 3325 1.00674812152551e-07 4808 5343475
SGTC_1786 berberine 21.6 µM -5.27427624038671 0.00468631777364743 no 3326 6.66405115795169e-08 4805 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_607 4491-0986 66.8 µM -5.31308838776845 0.00444471779792048 no 3327 5.38913628652625e-08 4810 698981 YDR232W HEM1
SGTC_3100 9120536 49.47 µM -5.4831578718572 0.00351215974981482 no 3328 2.08899928523433e-08 4807 16421196
SGTC_1731 st035964 63 µM -5.84765731701963 0.00207920856852076 no 3329 2.49272134469854e-09 4809 6739575
SGTC_1260 0700-1617 7.75 µM -6.21025288867108 0.0012018917495662 no 3330 2.64497005868325e-10 4809 2853078
SGTC_917 harmaline 728.087 nM -6.2345290192894 0.00115748615890969 no 3331 2.265696634921e-10 4795 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1103 duloxetine 36.1 µM -6.33783937042419 0.000984820194995653 yes 3332 1.16504781049289e-10 4810 60835 A selective serotonin reuptake inhibitor.
SGTC_58 0957-0393 9 µM -6.35499367190176 0.000958553038254312 yes 3333 1.04217600801509e-10 4734 6997992
SGTC_1728 st035614 33.7865 µM -6.6553653377723 0.000591313795479297 yes 3334 1.41298597850823e-11 4807 15945546
SGTC_722 3534-0461 190 µM -6.74267703275849 0.000512076311443635 yes 3335 7.77472997342534e-12 4809 658262
SGTC_1859 st055998 20 µM -7.27901933916173 0.000204470964485165 yes 3336 1.68127741550585e-13 4810 676301
SGTC_1348 1493-0373 93.8 µM -8.17344337807314 3.87689301334287e-05 yes 3337 1.498550261863e-16 4810 3010129