SGTCid condition conc unit IES5|YER092W.score IES5|YER092W.strain.pval IES5|YER092W.strain.significant IES5|YER092W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_952 1185-0122 232 µM 7.52401026820656 2.01004182776579e-12 yes 1 2.65605851016951e-14 3 678600
SGTC_453 enantio-paf c16 10 µM 6.62340252817254 4.97491550071736e-10 yes 2 1.75511711909906e-11 32 13871343 A lipid and platelet activating factor
SGTC_539 4859-0462 2.54 µM 5.86258575671004 3.11269987368648e-08 yes 3 2.2785705690403e-09 3 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2581 avocatin a 64 µM 5.70494458446055 6.91186169764584e-08 yes 4 5.81904727803508e-09 20 6710728 A skin care supplement.
SGTC_1399 3562-5772 25 µM 5.61138879857158 1.09910953721743e-07 yes 5 1.00354623695723e-08 4 23847490
SGTC_653 0203-0016 55.2 µM 5.58382067754275 1.25837331176369e-07 yes 6 1.17645657962975e-08 4 295302
SGTC_588 3970-1144 52.9 µM 5.51532905981996 1.75651527519662e-07 yes 7 1.74063986066096e-08 5 1888707
SGTC_3233 9132340 49.47 µM 5.40204094466327 3.02401207194641e-07 yes 8 3.29434527435068e-08 3 17682950
SGTC_435 c-PAF 6.7 µM 5.2711331856731 5.59189106226306e-07 yes 9 6.77920176671627e-08 14 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_7 0192-1582 4.227 µM 5.19365002565463 7.99333478544348e-07 yes 10 1.03105310999153e-07 33 252616
SGTC_2582 agaric acid 100 µM 4.97119556895235 2.16999012630061e-06 yes 11 3.32706426333574e-07 223 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1280 0880-0253 10.1 µM 4.88791511645679 3.12141793912338e-06 yes 12 5.09547248363571e-07 4 6836607
SGTC_378 3970-0959 8.33 µM 4.86164717590236 3.49661957101933e-06 yes 13 5.82064897209647e-07 7 6615653
SGTC_158 k038-0087 26.446 µM 4.81994262950285 4.18231218007861e-06 yes 14 7.17997553276703e-07 94 X158
SGTC_2651 TUB2.036 5 µM 4.74584225781245 5.72911956968139e-06 yes 15 1.0382024345998e-06 123 15992207 YFL037W TUB2
SGTC_1941 st076221 61.8 µM 4.57005255433631 1.18744998873625e-05 yes 16 2.43800961377232e-06 56 2828568
SGTC_1959 st077091 55.8 µM 4.50803398638161 1.52652726715837e-05 yes 17 3.27155484494108e-06 31 821356 YKL052C ASK1
SGTC_993 3909-8757 62.7 µM 4.46112050730847 1.84217579433015e-05 yes 18 4.07661120213599e-06 16 4288324 YLR208W SEC13
SGTC_1279 0874-0590 65.2 µM 4.4138511740999 2.22228235010576e-05 yes 19 5.07738904144583e-06 26 3523074
SGTC_1785 bathophenanthroline 24 µM 4.39170695710372 2.42491360190261e-05 yes 20 5.62321067594644e-06 32 72812 An iron chelator.
SGTC_2444 5485484 36.41 µM 4.348795443253 2.86844796449541e-05 yes 21 6.8443658593352e-06 24 6790631
SGTC_86 0417-1630 471.922 µM 4.34190602253239 2.94645187211544e-05 yes 22 7.06259768090478e-06 131 3634867
SGTC_2565 isoliquiritigenin 100 µM 4.31729862017301 3.24178224194445e-05 yes 23 7.89752014887349e-06 27 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1089 terbinafine 2.25 µM 4.28794291203163 3.63075787092588e-05 yes 24 9.01677117885552e-06 9 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_455 paf C-16 10 µM 4.25503585138867 4.11915020955167e-05 yes 25 1.04507761013945e-05 26 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2052 5265182 7.135 µM 4.24760378740859 4.23774058485943e-05 yes 26 1.08034538780308e-05 22 1239884
SGTC_430 0958-0115 16.4 µM 4.07932320976476 7.96346866339613e-05 yes 27 2.25835017946822e-05 27 6833180
SGTC_939 1165-0479 45.3 µM 4.0707651785929 8.21811701957522e-05 yes 28 2.34294830618056e-05 24 1377347
SGTC_2358 9037157 4 µM 3.96665526674148 0.000119960324124471 yes 29 3.64441494563556e-05 31 2388925
SGTC_418 lividomycin a 100 µM 3.89373319154047 0.000155546328223796 yes 30 4.93566096691273e-05 11 72394 An antibiotic.
SGTC_90 0870-0863 4.608 µM 3.86181118710061 0.000174048258669167 yes 31 5.62747682592619e-05 48 1738164
SGTC_1917 st066507 28.5 µM 3.82460929300942 0.000198202296474285 yes 32 6.54898166176978e-05 38 3156428
SGTC_2163 5671233 125 µM 3.79817753964362 0.000217229127167242 yes 33 7.28819519444107e-05 29 701023
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 3.72897374219938 0.000275426861692934 yes 34 9.61305912901129e-05 37 5377381
SGTC_2801 7907800 81.82 µM 3.71524547330412 0.00028857603802524 yes 35 0.000101503260509146 36 6620925
SGTC_89 0302-0250 142.109 µM 3.68448409106673 0.000320190533039064 yes 36 0.00011458316893138 29 4203518 YLR208W SEC13
SGTC_743 1275-0778 158 µM 3.67959289278818 0.00032550469641013 yes 37 0.000116803292499093 44 2849257 YMR203W TOM40
SGTC_739 1486-1183 203 µM 3.66448698690454 0.000342439204055019 yes 38 0.000123917419758429 23 4346692
SGTC_930 2810-3379 265 µM 3.62600669122477 0.000389348003268107 yes 39 0.000143918949304292 18 1015764
SGTC_151 3013-0144 2.285 µM 3.59902390626192 0.000425726002019841 yes 40 0.000159706914326099 41 906558 YHR107C CDC12
SGTC_3006 9075424 71.4286 µM 3.59266933655278 0.000434739957369476 yes 41 0.000163653909402793 16 7465181
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 3.58031490430022 0.000452773229014355 yes 42 0.000171590185889152 54 368090
SGTC_1972 st070201 17.4 µM 3.54205883886826 0.00051310514073781 yes 43 0.000198508452669067 36 2829099
SGTC_1705 st027868 56.3335 µM 3.53429634408277 0.000526221127961883 yes 44 0.000204431192235101 21 292948
SGTC_2310 7668677 200 µM 3.52649328958992 0.000539717701723856 yes 45 0.000210550918123496 50 2197143
SGTC_167 3672-0051 66.205 µM 3.47693145331151 0.000633194375506403 yes 46 0.000253593733516813 56 3237971
SGTC_735 3076-0345 636 µM 3.47512082919023 0.00063687677357049 yes 47 0.000255311647916153 43 2888990
SGTC_2543 pimpinellin 60.67 µM 3.46742880375577 0.000652742059151038 yes 48 0.000262731459731984 29 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3029 9088683 49.47 µM 3.46016201132734 0.000668064560704 yes 49 0.000269925238689061 33 25236615
SGTC_337 1315-0038 354 µM 3.43585718254147 0.000721756428304368 yes 50 0.000295341131764892 40 1626437
SGTC_2285 7945142 200 µM 3.42543347138585 0.000745979766811593 yes 51 0.000306909620929409 38 2970608
SGTC_2466 5983409 37.09 µM 3.42489776369665 0.000747244690303892 yes 52 0.000307515406316513 35 2879657
SGTC_513 4245-1575 41.7 µM 3.41413417187786 0.000773082343493264 yes 53 0.000319925286542544 151 719745
SGTC_1229 0139-0193 12.2 µM 3.37772325448855 0.000866706879259648 yes 54 0.00036544298315715 25 3090752
SGTC_2967 9089538 49.85 µM 3.31625481350253 0.00104871764210928 no 55 0.000456163013853831 58 728216
SGTC_339 3091-4833 71.4 µM 3.2921041444133 0.00112936068014639 no 56 0.000497203901024577 34 3240077
SGTC_1768 st044301 37.178 µM 3.27912453428438 0.00117501220615958 no 57 0.000520648364879081 39 3931349
SGTC_140 0062-0056 502.533 µM 3.2646110038085 0.0012280556408693 no 58 0.00054807251247897 48 3758964
SGTC_2097 5376186 200 µM 3.25756465463653 0.00125459061806059 no 59 0.00056186328068369 50 742755
SGTC_2069 5228469 200 µM 3.23757220629499 0.00133275833511498 no 60 0.000602757143278146 38 2835210
SGTC_398 bronopol 33.3 µM 3.21189265090816 0.00143968836054959 no 61 0.000659318189601115 49 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_891 0929-0073 133 µM 3.19124661710554 0.00153127581564385 no 62 0.000708301527497321 51 5603632
SGTC_3173 9105693 49.47 µM 3.18593781507414 0.001555669602012 no 63 0.000721428033620859 54 17096658
SGTC_165 k038-0023 64.381 µM 3.17960681726755 0.00158522328079541 no 64 0.000737375022721036 122 46368543
SGTC_142 0335-0849 62.6745 µM 3.17059027872862 0.00162819711489135 no 65 0.000760647760406354 185 3889043 YPR107C YTH1
SGTC_1841 st054148 70 µM 3.14471659634677 0.00175747254679543 no 66 0.000831238972635112 46 675442
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.13132065793126 0.00182801171984816 no 67 0.000870110187588644 50 75037 A free radical scavenger.
SGTC_176 1486-1328 72.834 µM 3.11079154841801 0.00194111794568798 no 68 0.000932933014082781 107 22310231
SGTC_198 3454-2873 16.191 µM 3.10844801183826 0.00195442611048474 no 69 0.000940363656284192 43 710957
SGTC_2467 5474540 200 µM 3.10369017502281 0.0019816995078947 no 70 0.000955616796690565 57 5413519
SGTC_529 4076-0302 30.3 µM 3.0932927022885 0.00204250764624269 no 71 0.000989743960480827 46 5816522
SGTC_2381 9035592 200 µM 3.08834912423699 0.00207200927395529 no 72 0.00100635932544278 52 4749657
SGTC_814 3342-0569 96 µM 3.04570672470219 0.00234298962573329 no 73 0.0011606706958232 72 4346283
SGTC_1248 0469-0687 58.6 µM 3.03556593076483 0.00241198136681387 no 74 0.0012004236329994 77 4017482
SGTC_811 0416-0114 265 µM 3.02103297201612 0.0025140612748099 no 75 0.00125956963226744 70 6612453
SGTC_2009 4012297 12.05 µM 3.01804807915333 0.00253550464160044 no 76 0.00127204269229606 111 45595307
SGTC_1545 lovastatin 49.4 µM 3.01528462543207 0.00255550444542432 no 77 0.0012836910200403 84 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2176 5809774 33.9695 µM 2.9999092457693 0.002669406261788 no 78 0.00135030029538095 45 2870539
SGTC_836 0330-0104 1.35 µM 2.99588501098483 0.00269996547287955 no 79 0.00136824801949127 52 46494820
SGTC_2520 obtusaquinone 4.71 µM 2.99218466526522 0.0027283435158728 no 80 0.00138494328599943 51 5967872
SGTC_116 0155-0182 31.788 µM 2.9646611346273 0.00294801354016634 no 81 0.00151508252929835 166 771486
SGTC_1426 4048-4480 71.7 µM 2.90443459156099 0.00348521579405013 no 82 0.00183958534794226 61 14224343
SGTC_1467 k284-1082 293 µM 2.90420207082255 0.00348744999340706 no 83 0.00184095219738914 63 3334705
SGTC_728 3030-5151 22.5 µM 2.90286849341688 0.00350028867217206 no 84 0.00184880934655484 41 3125388
SGTC_464 bw-b 70c 158 µM 2.89873068761222 0.0035403949671536 no 85 0.00187338284471396 80 5353454
SGTC_466 geldanamycin 89.2 µM 2.89699848018297 0.00355730681010362 no 86 0.00188375790278348 34 5288382 HSP90 inhibitor.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.88985161439674 0.00362785240524844 no 87 0.00192711854168073 160 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_926 2268-1401 59.4 µM 2.88446033380515 0.00368189691367241 no 88 0.00196042574747182 71 2931578
SGTC_854 0422-0053 192 µM 2.88249748822909 0.0037017519597611 no 89 0.00197268140720984 54 3596728
SGTC_137 0438-0332 85.389 µM 2.88099483398335 0.00371701681654469 no 90 0.00198211068970256 205 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2352 9027995 87.8 µM 2.86346714628465 0.00389928926126366 no 91 0.00209516133415822 71 2997347
SGTC_1375 2910-0797 186 µM 2.86117453812175 0.00392371332047351 no 92 0.00211037308368479 75 742508
SGTC_1491 4138-0063 26.5 µM 2.85626774775202 0.00397644838688563 no 93 0.00214326742642933 36 23883227
SGTC_740 k014-0057 261 µM 2.84477335568858 0.00410247579511539 no 94 0.00222215167208535 84 4012779
SGTC_9 0092-0002 10.449 µM 2.82773135085638 0.0042959108574839 no 95 0.00234395643408332 90 759368
SGTC_2289 7946404 165.07 µM 2.81598967708169 0.004433887843021 no 96 0.00243136145578395 172 1246120 YPR165W RHO1
SGTC_1988 st071872 53.4 µM 2.81577717757328 0.00443642099500051 no 97 0.00243297011559471 56 16414116
SGTC_3059 1327-0034 3 µM 2.813660606225 0.0044617227514873 no 98 0.00244904558239618 109 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1774 st048371 48.465 µM 2.80288379918424 0.00459255944460363 no 99 0.00253239569966272 81 4242727
SGTC_103 0844-0104 51.839 µM 2.78341962245698 0.00483756788829298 no 100 0.00268945941534532 238 5375804
SGTC_661 1304-0007 33.6 µM 2.78017991247126 0.00487946055952826 no 101 0.00271643948775796 72 3117130
SGTC_905 2-aminofluorene 215 µM 2.77841432011232 0.00490242727982873 no 102 0.0027312458598831 96 1539 An established DNA mutagen. YPR165W RHO1
SGTC_462 ag-879 158 µM 2.77434780444681 0.00495569109212837 no 103 0.00276562541285789 102 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.76101596819258 0.00513394743441558 no 104 0.00288109295081623 56 2724278 An inhibitor of dopamine biosynthesis.
SGTC_907 3448-6986 75.5 µM 2.7417323795207 0.0054018813152217 no 105 0.00305580567035905 98 590582
SGTC_765 1319-0117 244 µM 2.71606847408546 0.00577771649628254 no 106 0.00330311265897225 69 3487746 YGL099W LSG1
SGTC_1609 st001574 46.4 µM 2.71182444932126 0.00584205576185345 no 107 0.00334570101487773 78 3960012
SGTC_1392 3455-1037 33.9 µM 2.71140462855423 0.00584845464713978 no 108 0.00334994058842015 78 981132
SGTC_1062 mesoridazine 14.2 µM 2.69930813049742 0.00603551932982525 no 109 0.00347419046788994 82 4078 A neuroleptic.
SGTC_725 1497-0963 19 µM 2.69742642639894 0.00606509048650533 no 110 0.00349388621026726 75 3549977
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.68665835273505 0.00623679438072191 no 111 0.00360853648749133 80 4213774
SGTC_281 1672-3440 14.9 µM 2.68091537981746 0.00633011858807096 no 112 0.00367105397414725 52 6833000
SGTC_1813 st051246 8.6015 µM 2.67723286014384 0.00639060858409082 no 113 0.00371165114488421 60 5291959
SGTC_2432 5630864 12.22 µM 2.66194175072819 0.00664729097641974 no 114 0.00388456608847183 123 5714970
SGTC_2540 epiandrosterone 100 µM 2.64641836769361 0.00691715314233062 no 115 0.00406745684455861 180 441302 A steroid.
SGTC_36 0335-0881 14.2 µM 2.63468996112805 0.00712741245175966 no 116 0.00421070831779061 229 23828853
SGTC_3119 9125183 49.47 µM 2.63376837060913 0.00714417061084511 no 117 0.00422215363913268 50 22695334
SGTC_913 3487-1245 167 µM 2.62734383925278 0.00726196279411115 no 118 0.00430271651154848 123 4016153
SGTC_2908 7930301 100 µM 2.62338074490018 0.00733547618061846 no 119 0.00435309590049399 131 2223178
SGTC_2089 5281248 129.67 µM 2.60308349058801 0.00772235568213884 no 120 0.00461947257355652 109 2737878
SGTC_3032 9089427 49.47 µM 2.60284343436529 0.00772703678353095 no 121 0.0046227082087027 82 17173707
SGTC_2584 androsterone 48.74 µM 2.59941055854932 0.00779425166281865 no 122 0.00466920052654807 274 2754130 A steroid.
SGTC_1773 st048542 73.5835 µM 2.58410027264497 0.00810032620449188 no 123 0.00488167022873537 133 3237138
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.57532589217591 0.00828045888858392 no 124 0.0050072839202983 100 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1219 1469-0211 33.1 µM 2.5698859101672 0.00839389677466427 no 125 0.00508660063350956 77 6822282
SGTC_1933 st074711 15.9 µM 2.56729717265818 0.00844835618987634 no 126 0.00512473658188206 147 17250958
SGTC_1782 st039423 80.636 µM 2.55720737007122 0.00866358685684064 no 127 0.00527581473448724 119 2068169
SGTC_1750 st081859 2.357 µM 2.54575671203463 0.0089136585852163 no 128 0.0054520577379089 333 5291695
SGTC_682 0kpi-0099 17 µM 2.5368062379379 0.00911351037319554 no 129 0.00559344260130424 166 1714895 YML126C ERG13
SGTC_843 0310-0051 143 µM 2.52784092088021 0.00931761573493455 no 130 0.00573831697665794 100 2065037
SGTC_1554 st069299 38.7 µM 2.51707031349392 0.00956809991306146 no 131 0.00591676054050373 106 24207999
SGTC_188 3229-0966 278.469 µM 2.51628198440297 0.00958666256924718 no 132 0.00593001253165019 130 5722370
SGTC_3040 9091894 49.47 µM 2.49428917775475 0.0101173680773442 no 133 0.00631048377086662 88 25236966
SGTC_2825 7998094 58.44 µM 2.49138268818491 0.0101893874500775 no 134 0.00636234902591182 118 2987815
SGTC_309 k408-0051 1.48 µM 2.48732208442491 0.0102907530317359 no 135 0.00643544069077168 193 3640463
SGTC_911 3456-4043 236 µM 2.4833486918672 0.0103907916158671 no 136 0.00650768072867604 140 914281
SGTC_1337 1486-1011 40.3 µM 2.4755864888611 0.0105886694727388 no 137 0.0066508769819244 98 X1337
SGTC_861 0443-0273 110 µM 2.47300840582312 0.0106551134975271 no 138 0.00669904957975069 106 6149169
SGTC_1433 4060-0023 7.6 µM 2.47272952698458 0.0106623226620373 no 139 0.00670427898962976 100 3840627
SGTC_628 1636-0253 16 µM 2.4708781194253 0.0107102903204063 no 140 0.00673908731517646 157 4456143
SGTC_16 erodoxin 22.806 µM 2.46230763580113 0.0109347971670573 no 141 0.00690231013450012 189 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2569 tetrandrine 100 µM 2.45186232073438 0.0112139433545809 no 142 0.00710595139294675 124 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_641 4092-0595 30 µM 2.43542221662859 0.0116658469828143 no 143 0.00743721110068281 114 786260
SGTC_2814 7977482 42.97 µM 2.43060179504704 0.0118013122294746 no 144 0.00753688553199378 183 6456762
SGTC_2213 7173844 200 µM 2.42059469600641 0.0120868994307225 no 145 0.00774757144138515 115 892728
SGTC_1483 3453-0561 55.9 µM 2.41768774185227 0.0121709744710701 no 146 0.00780973706589054 124 4546991
SGTC_53 0973-0023 39.979 µM 2.40528677241058 0.0125353538082644 no 147 0.00807988963080865 120 674768
SGTC_245 methotrexate 289.6 µM 2.39079876822234 0.0129729851412854 no 148 0.00840588224946939 153 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2773 thioridazine 9.09 µM 2.38391150605146 0.0131856166099603 no 149 0.00856486049969703 110 5452 An antipsychotic.
SGTC_3220 9131269 49.47 µM 2.38227401801762 0.0132366118752639 no 150 0.00860304444293793 83 17722206
SGTC_1181 1222-0449 220 µM 2.36353537237477 0.0138324155089468 no 151 0.00905074927157608 137 658318
SGTC_762 1165-0429 115 µM 2.36298106173022 0.0138503867053642 no 152 0.00906429799167343 134 5967793
SGTC_2318 6029776 164 µM 2.35230453013836 0.0142004778070787 no 153 0.00932874652277813 162 818325
SGTC_552 k242-0005 476 µM 2.33212857181491 0.0148829101410201 no 154 0.00984696418860812 120 4088318
SGTC_1872 amphotericin b 148 nM 2.32583162669907 0.0151015918068353 no 155 0.0100137673623997 145 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2697 mebhydrolin 72.4 µM 2.31095184171419 0.015629337815742 no 156 0.0104177575412855 225 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.30685795534871 0.0157772837837869 no 157 0.0105313700469762 191 6728940
SGTC_3306 9127676 59.7925 µM 2.29868846562142 0.0160761077848516 no 158 0.010761317986097 146 41905287
SGTC_2474 5321570 43.32 µM 2.29845144186984 0.0160848495671075 no 159 0.0107680542800458 126 2841384
SGTC_3114 9122766 49.47 µM 2.29539660692494 0.0161978814297909 no 160 0.0108552028170527 156 17176985
SGTC_1068 loratadine 26.9 µM 2.29118752225288 0.0163547359311286 no 161 0.0109762851618403 146 3957 A H1 histamine antagonist.
SGTC_2803 7707263 71.43 µM 2.28937432459206 0.0164227058275502 no 162 0.0110288063106654 161 2199229
SGTC_2968 9090663 33.37 µM 2.28844281448841 0.0164577185490897 no 163 0.0110558733692149 169 25236811
SGTC_1987 st072290 61.9 µM 2.28403256954025 0.0166243554594744 no 164 0.0111848084477972 134 54697379
SGTC_2067 5224629 34.075 µM 2.28246445784121 0.0166839520068813 no 165 0.0112309667779267 157 2835000
SGTC_1186 1319-0216 26 µM 2.28190100443153 0.0167054108153635 no 166 0.011247592768417 161 4565136
SGTC_2808 7946468 45.46 µM 2.28041908628148 0.0167619615932365 no 167 0.0112914223448328 177 2970879
SGTC_1795 st049545 62.3 µM 2.2779832821524 0.0168552689513713 no 168 0.0113637868344047 111 5291882
SGTC_1409 3909-8004 61.9 µM 2.27603231900658 0.0169303237389736 no 169 0.0114220376631121 183 2119279
SGTC_2993 9054257 71.4286 µM 2.27057444902554 0.017141811080183 no 170 0.0115863758436776 220 6470217 YGL055W OLE1
SGTC_3089 9117425 49.47 µM 2.2696289118051 0.0171786782580076 no 171 0.0116150539519866 182 9401657
SGTC_343 4130-2827 29.8 µM 2.26748260435086 0.0172626158504227 no 172 0.0116803801944109 172 1118244
SGTC_1464 k208-0027 110 µM 2.2660204228123 0.0173199991474336 no 173 0.0117250664256075 138 X1464
SGTC_2362 9071156 126 µM 2.26490330850663 0.017363950003554 no 174 0.0117593068544523 137 653133
SGTC_1934 st074720 32.6 µM 2.25948251301321 0.0175785764188921 no 175 0.0119266934330317 219 17250992
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.25571522905507 0.0177290652758605 no 176 0.0120442356007572 155 688801
SGTC_2431 5490079 200 µM 2.25165564957163 0.0178924593661827 no 177 0.0121720206960434 184 5722345
SGTC_2210 7115885 190.385 µM 2.24875821341324 0.0180098622609426 no 178 0.0122639416317011 161 2927039
SGTC_1411 3909-8223 150 µM 2.24864272593149 0.018014555344783 no 179 0.0122676178945607 127 X1411
SGTC_3215 9129942 49.47 µM 2.24837749250266 0.018025337626718 no 180 0.0122760645700001 118 17682944
SGTC_794 k038-0031 316 µM 2.23508398403572 0.0185728395984703 no 181 0.0127059178169793 265 6624242
SGTC_250 brefeldin a 552.239 µM 2.23474166657049 0.0185871231383535 no 182 0.012717156732831 112 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_619 1652-1634 108 µM 2.23285914660022 0.0186658404107102 no 183 0.0127791171963035 149 5400454
SGTC_1696 st025591 34.7925 µM 2.22993405099646 0.018788715754053 no 184 0.0128759107055698 180 2787147
SGTC_1510 1123-0200 71.5 µM 2.22752777921643 0.018890312068849 no 185 0.0129560106794012 219 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_983 1491-0821 12.2 µM 2.22318827230124 0.0190747139352959 no 186 0.0131015536542919 137 46495113
SGTC_1018 4259-0013 28.1 µM 2.22313710946466 0.0190768971324334 no 187 0.0131032780017826 145 6801262
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.22300509527495 0.0190825313629264 no 188 0.0131077281985883 138 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2738 aclarubicin 5.55 µM 2.22244552070698 0.0191064291447393 no 189 0.0131266059568167 101 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1625 st003711 30.1 µM 2.21725094676833 0.0193294911250227 no 190 0.0133029739493374 174 24207034 YER133W GLC7
SGTC_117 lucigenin 22.078 µM 2.21573521829723 0.0193949941304698 no 191 0.0133548207116971 258 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1308 1187-1617 41.4 µM 2.2127733848112 0.0195235357513613 no 192 0.0134566365438263 202 2882570
SGTC_2707 st078556 66.6 µM 2.21184488555386 0.019563980682329 no 193 0.0134886922540249 125 17250899
SGTC_1076 itraconazole 331 nM 2.20945537725817 0.01966839370579 no 194 0.0135714914440905 168 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_12 0849-0099 9.267 µM 2.19679088202541 0.0202297189502442 no 195 0.0140176922842022 141 6071388
SGTC_580 1123-0028 41 µM 2.18552161920773 0.0207405672974196 no 196 0.0144253112852002 237 1677248 YPR107C YTH1
SGTC_2718 lomofungin 53.02 µM 2.1836551264946 0.0208262232477004 no 197 0.0144937997428299 126 5351222 A RNA synthesis inhibitor.
SGTC_1137 ixabepilone 100 µM 2.18296999461301 0.0208577399581033 no 198 0.0145190098758969 222 154225 A novel microtubule stabilizer.
SGTC_277 nystatin 15.5 µM 2.18105163420555 0.0209462012154469 no 199 0.0145897988030392 180 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1707 st032323 6.317 µM 2.17799364360925 0.0210878706439017 no 200 0.0147032549932046 235 3132057 YMR211W DML1
SGTC_3208 9114115 49.47 µM 2.17443775362745 0.0212536251883865 no 201 0.0148361376832137 202 650895
SGTC_2644 guaiazulene 100 µM 2.16311115038451 0.0217889672328247 no 202 0.0152663158478619 126 3515 A coloring agent.
SGTC_2208 7283366 200 µM 2.16194010599762 0.0218449596955758 no 203 0.0153113965560475 152 898663
SGTC_2330 7979373 200 µM 2.16115950977025 0.0218823506806955 no 204 0.0153415099723202 210 1863007
SGTC_2655 perillic acid 100 µM 2.16108024945888 0.0218861503135561 no 205 0.0153445704757343 98 5702197 An apoptosis inducer.
SGTC_1661 st013063 9.66 µM 2.15877573818446 0.0219968693310162 no 206 0.015433784808964 207 721395
SGTC_2477 5967686 25.23 µM 2.15374728718626 0.0222401009653998 no 207 0.0156299977923489 175 776118
SGTC_3054 9094397 49.47 µM 2.14426236203208 0.0227050764718839 no 208 0.0160059353850811 226 2598354
SGTC_1805 st050013 60.3 µM 2.14117228719605 0.022858318412827 no 209 0.0161300734927531 141 4037144
SGTC_1825 st052143 62.6 µM 2.13333588218923 0.0232508501000306 no 210 0.01644859135242 144 674173
SGTC_1244 0416-0015 52.5 µM 2.13209301087442 0.0233136248484603 no 211 0.0164996005416877 206 96201
SGTC_2414 st077232 92.9 µM 2.13084535697572 0.0233767845617987 no 212 0.0165509421469018 197 729801
SGTC_3219 9131112 49.47 µM 2.12615183996234 0.0236156745977668 no 213 0.0167453093252621 189 17612988 YMR079W SEC14
SGTC_2757 clomiphene 4.22 µM 2.12149452050213 0.0238547484266225 no 214 0.0169401042871054 222 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_683 panaxydol 45 µM 2.11949294995077 0.0239581181876997 no 215 0.0170244144687947 189 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_522 1273-0010 11.6 µM 2.11490065835151 0.0241967072671828 no 216 0.0172192075378433 192 5705015
SGTC_2451 5856223 45.7 µM 2.11194255131255 0.0243514478193493 no 217 0.0173456885404276 185 2179896
SGTC_2189 6047310 154.431 µM 2.10085705961136 0.0249387477185551 no 218 0.0178267579070173 169 711535
SGTC_2061 5245884 80.95 µM 2.10041411079721 0.0249624594157035 no 219 0.0178462143988265 201 573863
SGTC_1196 1588-0294 184 µM 2.09134922364575 0.0254518831112347 no 220 0.0182483851592667 182 6144269
SGTC_1101 ebselen 5.29 µM 2.08767417835708 0.0256525799359746 no 221 0.0184136178160351 198 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1435 4092-0789 56.7 µM 2.08163793815532 0.0259850976636879 no 222 0.0186877766760939 170 2248285
SGTC_2920 7982904 15.77 µM 2.08144744921709 0.0259956495214209 no 223 0.0186964847062364 186 6456808
SGTC_2676 harmalol 100 µM 2.07597256591999 0.0263004580746289 no 224 0.0189482441908463 176 5459187 A monoamine oxidase inhibitor
SGTC_409 arachidonic acid 100 µM 2.07079403801078 0.0265915111420139 no 225 0.0191890238172641 184 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2083 5306046 65.942 µM 2.07038906813525 0.0266143849955801 no 226 0.0192079623664133 232 539837
SGTC_1055 3448-0672 86 µM 2.06382451978511 0.0269874678561746 no 227 0.0195171786820009 214 748378
SGTC_1916 st067606 49.2 µM 2.06104261215444 0.0271468836945606 no 228 0.0196494874812039 255 19590279
SGTC_2333 9017922 200 µM 2.04500552441976 0.0280812737399314 no 229 0.0204271567328249 208 3163164
SGTC_2505 galangin 7.89 µM 2.04248199055329 0.0282307164660833 no 230 0.0205518720357093 144 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_775 4577-0580 57.3 µM 2.04179833398146 0.0282713161283294 no 231 0.020585769798266 184 2006902
SGTC_163 TUB2.036 7.546 µM 2.03691880339966 0.0285625056137166 no 232 0.0208290897416716 383 15992207 YJR013W GPI14
SGTC_542 3381-0244 89.3 µM 2.03154810888705 0.0288858853356166 no 233 0.0210997122447907 239 1112843
SGTC_3299 9121982 43.1275 µM 2.03012778494883 0.0289719127668986 no 234 0.0211717759553172 221 17594604 YPL160W CDC60
SGTC_2769 toremifene 3.73 µM 2.02855551590009 0.02906739154594 no 235 0.0212517916764751 200 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_318 1488-0629 67.2 µM 2.02295763070256 0.0294094578104217 no 236 0.0215387579899369 182 3662576
SGTC_1164 k060-0068 93.7 µM 2.0180495444104 0.0297121166258341 no 237 0.0217930508447714 241 5963676
SGTC_13 0199-0087 65 µM 2.01410966720005 0.0299569364863866 no 238 0.0219990103962242 193 4589825
SGTC_2290 7904846 200 µM 2.00772667915781 0.0303571180014372 no 239 0.0223361719812422 238 2962154
SGTC_2156 5649887 115 µM 2.0018990295008 0.0307263412297606 no 240 0.022647796033501 233 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_985 1493-0307 8.71 µM 1.96973244315279 0.032831807258415 no 241 0.0244345213425006 169 3278274
SGTC_2129 girgensonine 121.053 µM 1.96840241284205 0.032921363753555 no 242 0.0245108772514702 260 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1282 0886-0010 32.4 µM 1.96609407846384 0.0330772714567247 no 243 0.0246438721497951 254 2836211 YNL267W PIK1
SGTC_457 grayanotoxin iii 135 µM 1.95735688105369 0.0336729109190638 no 244 0.0251527621342145 349 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2142 5622915 118.518 µM 1.95265727609524 0.0339969297077577 no 245 0.0254301096967212 197 5322196
SGTC_1220 1838-0075 193 µM 1.94734266516632 0.0343664355416058 no 246 0.0257468334356539 234 5529645
SGTC_2720 fluspirilene 36.88 µM 1.94460319512294 0.0345581863209213 no 247 0.0259113772332645 177 3396 An atypical antipsychotic.
SGTC_839 0122-0028 230 µM 1.943471340352 0.0346376673026386 no 248 0.0259796174529361 311 759448
SGTC_2829 7992743 58.44 µM 1.93690718750957 0.0351015797291534 no 249 0.0263783448534429 279 16462845
SGTC_80 0159-0065 512.242 µM 1.93633632503766 0.0351421644857849 no 250 0.0264132612982643 127 1548079
SGTC_599 1935-0052 86.5 µM 1.93589418346246 0.0351736244411746 no 251 0.0264403311462224 242 9557311
SGTC_727 3032-0951 202 µM 1.9326274583308 0.0354067803157725 no 252 0.0266410536743711 232 3652836
SGTC_2706 st078239 82.5 µM 1.92992978998707 0.035600275031641 no 253 0.0268077688523012 217 15434492
SGTC_1032 k061-1018 98.7 µM 1.92478079428949 0.0359720012731138 no 254 0.0271283938532999 291 4005393
SGTC_918 glabranin 770.725 nM 1.92357857866159 0.0360592502241131 no 255 0.0272037141306862 259 124049 Also referred to as licorice root.
SGTC_1745 st081495 74 µM 1.92245085871179 0.0361412502263535 no 256 0.0272745256674028 344 13842402 YBL026W LSM2
SGTC_3027 9089541 49.47 µM 1.92004721584974 0.0363165361143578 no 257 0.0274259678482847 255 9943819
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.91231400262915 0.0368852077537566 no 258 0.0279179654281897 264 4174840
SGTC_535 2293-4129 48.2 µM 1.91093355159261 0.0369874828056493 no 259 0.0280065603471397 322 396118 YIL048W NEO1
SGTC_2931 9014674 55.67 µM 1.90957479042379 0.0370883771645279 no 260 0.0280939917772249 254 2996810
SGTC_1160 4092-0570 10.5 µM 1.89653683273684 0.038067985120366 no 261 0.0289445471604989 285 4994975
SGTC_888 0916-0002 6.97 µM 1.89609694607804 0.0381014006093223 no 262 0.0289736131782029 233 2802138 YIL048W NEO1
SGTC_668 1682-0499 62.6 µM 1.89328962567038 0.0383152194592295 no 263 0.0291596820175516 281 682214
SGTC_1354 1498-1681 81 µM 1.88890139109751 0.0386514071668219 no 264 0.0294525215243934 261 5754243
SGTC_938 3126-1755 342 µM 1.8881021005081 0.0387128997327399 no 265 0.0295061224686251 240 1777771
SGTC_1534 6-azauridine 81.6 µM 1.88127171386289 0.0392416451498537 no 266 0.0299674833775959 293 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2105 5350118 200 µM 1.87800566091951 0.0394965418710373 no 267 0.0301901953379463 258 2133313
SGTC_1838 st055369 84.5 µM 1.87615908912697 0.0396412511759174 no 268 0.0303167189336249 227 676036
SGTC_249 wiskostatin 11.211 µM 1.86515982904655 0.0405121807426417 no 269 0.031079502205903 220 2775510 A n-wasp and actin depolymerizer.
SGTC_2557 derrustone 83.84 µM 1.86223944512216 0.0407460103649522 no 270 0.0312846733632492 334 629853 An antioxidant.
SGTC_3334 9142812 21.919 µM 1.85966597300006 0.0409529700637245 no 271 0.0314663995235301 261 45283678
SGTC_863 0466-0191 129 µM 1.85894407802637 0.0410111780494449 no 272 0.0315175327031283 315 765160 YPR165W RHO1
SGTC_2215 7188065 200 µM 1.85408360310446 0.0414048377705993 no 273 0.0318636000802612 180 940217
SGTC_2055 5235184 200 µM 1.84974239054815 0.0417590252726081 no 274 0.0321753438126201 281 2836034
SGTC_578 3460-0051 92 µM 1.84836454748244 0.0418719512865978 no 275 0.0322748118989225 296 2876744
SGTC_2034 5197015 53.07 µM 1.8460201802979 0.0420646603855938 no 276 0.032444637662562 261 780676
SGTC_2172 5754775 163.918 µM 1.83998194973449 0.0425643153728792 no 277 0.0328854436936248 277 2263357
SGTC_3235 9132602 49.47 µM 1.83800026862972 0.0427293387964741 no 278 0.0330311828630167 292 4912240
SGTC_1407 3909-7909 12.3 µM 1.83000993036431 0.0433999838992038 no 279 0.033624226970151 281 4411780
SGTC_978 1416-0512 87.4 µM 1.82423137160909 0.0438902650062479 no 280 0.0340585503466764 309 6814003
SGTC_244 nsc-207895 1.295 µM 1.8222729475811 0.0440574373006314 no 281 0.0342067904058179 189 42640
SGTC_3007 9078383 71.4286 µM 1.82123981402729 0.0441458328684981 no 282 0.0342852054000879 267 6496995
SGTC_955 1216-0110 33 µM 1.81948842404456 0.0442960095100051 no 283 0.0344184736517931 366 3619719
SGTC_2251 lansoprazole 556 µM 1.81919504101868 0.0443212064757452 no 284 0.0344408395705481 214 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1495 4469-0029 237 µM 1.81723352262589 0.0444899668322614 no 285 0.0345906820179834 428 793680
SGTC_352 k048-0007 5.11 µM 1.81682778096947 0.0445249395854198 no 286 0.034621743791961 334 6811911
SGTC_2088 5278280 127.392 µM 1.81539398885599 0.0446487022195499 no 287 0.0347316921003351 312 791502
SGTC_2114 5491910 81.25 µM 1.81459293028557 0.0447179688639693 no 288 0.0347932448770652 260 2849228
SGTC_2858 9025781 8.96 µM 1.80766964761843 0.0453202297911288 no 289 0.0353289656384646 414 4894980 YPL153C RAD53
SGTC_3150 9097574 49.47 µM 1.80362844279249 0.0456747818605867 no 290 0.0356447870556736 224 17217476
SGTC_385 1494-0393 12.4 µM 1.80252473461798 0.0457720015373779 no 291 0.0357314433665999 289 3090647
SGTC_1852 st056254 31.4 µM 1.79861899716177 0.0461173731406384 no 292 0.0360394850974076 261 442583
SGTC_1778 st046819 58.9 µM 1.79810426738561 0.0461630447075142 no 293 0.0360802430618779 340 671715
SGTC_2063 5246145 200 µM 1.7968759798599 0.0462721764630687 no 294 0.0361776553591008 312 711240
SGTC_1762 st045503 25.4615 µM 1.79218034500274 0.0466912886089245 no 295 0.0365520410204121 292 4645554
SGTC_2893 9048488 25.97 µM 1.79109016815751 0.0467890274545398 no 296 0.0366394133236039 266 6467338
SGTC_1900 st060200 72.8 µM 1.78997197612193 0.0468894484143776 no 297 0.0367292083175995 276 688945
SGTC_1898 st060199 18.6 µM 1.78681903508272 0.0471735342607367 no 298 0.0369833708858117 255 688866
SGTC_276 colchicine 750 µM 1.78308945078312 0.0475113562303285 no 299 0.0372858716996065 315 2833 A microtubule depolymerizer.
SGTC_11 0438-0307 1.3 µM 1.78022326157997 0.0477722875108298 no 300 0.0375197149797352 251 4011476
SGTC_821 1114-0266 29.2 µM 1.77852533140619 0.0479274035937849 no 301 0.0376588076671572 270 3123235
SGTC_2617 dihydrotanshinone i 20.83 µM 1.77482127289706 0.0482671906322627 no 302 0.0379637013332904 340 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_255 tunicamycin 200.472 nM 1.7704535409329 0.0486703319286862 no 303 0.0383258086538213 328 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3251 9135047 49.47 µM 1.76457949627752 0.0492167448583557 no 304 0.0388172319726182 207 17682963
SGTC_3347 9188721 44.724 µM 1.76138224554424 0.0495162106819084 no 305 0.0390868639986139 256 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1474 0330-0125 5.35 µM 1.75682894924168 0.0499451968820229 no 306 0.0394734845545588 290 X1474
SGTC_833 3852-0053 558 µM 1.74439023168892 0.0511322229072172 no 307 0.0405455335851047 328 3123681
SGTC_1984 st072354 53.1 µM 1.73555146656927 0.0519892686737547 no 308 0.0413215869152211 264 5762938
SGTC_786 4544-0069 423 µM 1.7342845882646 0.0521130406060892 no 309 0.041433800318638 334 748821 YLR208W SEC13
SGTC_646 4092-0839 27.3 µM 1.73295928954608 0.052242770502273 no 310 0.0415514524535127 299 877796
SGTC_2847 9005661 71.43 µM 1.73211004764039 0.052326035226554 no 311 0.0416269852848488 177 2991449
SGTC_962 1254-0300 21.5 µM 1.72236758855592 0.053288800244819 no 312 0.0425014755658919 298 7340576
SGTC_997 3996-0078 137 µM 1.71830571494111 0.0536943254146034 no 313 0.042870433760488 337 735687
SGTC_59 0330-0160 1.33 µM 1.7140121043769 0.0541256399310285 no 314 0.04326325142282 499 4293482
SGTC_1485 3909-9022 254 µM 1.71309718164263 0.0542179019164805 no 315 0.0433473312268096 304 714516
SGTC_1361 1608-0041 5.61 µM 1.70665521799485 0.0548710452693309 no 316 0.0439430776848439 326 X1361
SGTC_2248 tofa 1.1 µM 1.70324559624573 0.0552192511145825 no 317 0.0442610585107956 288 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1064 honokiol 6.76 µM 1.7018442136297 0.0553628717032279 no 318 0.0443922878740343 322 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2447 5741742 33.78 µM 1.70178212986994 0.0553692411694686 no 319 0.0443981088146616 353 1776504
SGTC_583 1488-1091 88.9 µM 1.70140301353851 0.0554081490617685 no 320 0.0444336679089071 396 4303273
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.70080732191702 0.0554693272147999 no 321 0.0444895869650184 310 5355888
SGTC_55 0767-0285 6.563 µM 1.70050052468035 0.0555008564118138 no 322 0.0445184088978313 390 3116166
SGTC_1608 st001473 40.5 µM 1.69840720229299 0.0557163624921479 no 323 0.0447154668455405 334 7292267
SGTC_2791 5663188 71.43 µM 1.69796722999648 0.0557617412064635 no 324 0.0447569734821983 317 54690634
SGTC_2603 homopterocarpin 100 µM 1.69044727454157 0.056541866660956 no 325 0.0454712086396551 364 101795 A weak amylase inhibitor.
SGTC_1291 0993-0025 5.79 µM 1.68788630759204 0.0568094976820742 no 326 0.0457165277685954 312 4353356
SGTC_2150 5556613 200 µM 1.68690413914048 0.0569124024179113 no 327 0.0458108930339828 350 743190
SGTC_1615 st002656 86.5 µM 1.67986738930981 0.0576539626952283 no 328 0.046491559969712 315 1584458
SGTC_2983 9022671 12.99 µM 1.6728663685421 0.0583992775311003 no 329 0.047176802920923 310 6405161
SGTC_1864 st057645 30.4 µM 1.67138273283829 0.0585581899335752 no 330 0.047323052160407 283 688666
SGTC_2464 5717415 7.67 µM 1.66799446960557 0.0589223802067311 no 331 0.0476584123200911 344 5285744
SGTC_1307 1187-1599 12.2 µM 1.66753041915129 0.0589723971204674 no 332 0.0477044904753125 317 1538471
SGTC_1964 st076914 61 µM 1.66469064514769 0.0592792034654839 no 333 0.0479872451542006 300 24208661
SGTC_2099 5377090 177.372 µM 1.66321427524184 0.059439202738212 no 334 0.0481347755636101 360 2243829
SGTC_1336 1486-0901 104 µM 1.66145098633153 0.0596307397875538 no 335 0.0483114525007192 331 5006114
SGTC_2634 4'-methoxyflavone 100 µM 1.65922395988355 0.0598733410703749 no 336 0.0485353356164223 336 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1460 k062-0059 9.15 µM 1.65697877979105 0.060118701817717 no 337 0.0487618826946489 316 1373085
SGTC_1792 st045773 43.6 µM 1.65033413039212 0.0608494652890165 no 338 0.0494373076323774 352 2919270
SGTC_1424 4048-1941 275 µM 1.64893894892726 0.0610037828721417 no 339 0.0495800713612349 366 X1424
SGTC_1733 st037357 54.9 µM 1.64846014406061 0.0610568127520259 no 340 0.049629141443364 386 1272339 YGL099W LSG1
SGTC_1163 k060-0048 49.9 µM 1.64844326549571 0.0610586827893546 no 341 0.0496308719417008 388 6809982
SGTC_1616 st002734 56.1 µM 1.64682274591442 0.061238434599066 no 342 0.0497972423203582 384 4026101
SGTC_2939 9044578 71.43 µM 1.64378297018123 0.061576728596504 no 343 0.0501105201390057 361 2653634
SGTC_3311 9131146 2.8755 µM 1.63077136802456 0.0630412962518343 no 344 0.0514692855362877 411 4900406 YPR165W RHO1
SGTC_2401 5128683 200 µM 1.62968515864721 0.063164775165601 no 345 0.0515840278348461 337 708373
SGTC_1031 k035-0009 16 µM 1.62693932946573 0.0634777573962759 no 346 0.0518749919609547 393 5180959
SGTC_2883 9059145 45.46 µM 1.62485949199684 0.0637156291712069 no 347 0.052096250603572 311 16476510
SGTC_592 k241-0073 46.5 µM 1.62413323750268 0.0637988543208982 no 348 0.0521736878418498 369 4230158
SGTC_2856 9022925 19.48 µM 1.62139480812608 0.0641134254031409 no 349 0.0524664967644816 373 4944862
SGTC_19 0279-0214 38.434 µM 1.61850816546175 0.0644463262400216 no 350 0.0527765642654699 449 3566274 YBR002C RER2
SGTC_2369 9071472 200 µM 1.61769605773954 0.0645402238682967 no 351 0.0528640580085951 377 17296037
SGTC_112 phenothiazine 287.218 µM 1.61482635940729 0.0648728759791071 no 352 0.0531741515707575 352 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.61455661656978 0.0649042125726124 no 353 0.0532033734063021 448 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2607 solasodine 47.35 µM 1.60847644891461 0.0656136805626341 no 354 0.0538654350761718 414 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1657 st012939 43.4 µM 1.60635577215968 0.0658625424603264 no 355 0.0540978813291032 312 24207257
SGTC_364 0083-0097 67.7 µM 1.60389912575928 0.0661517443191092 no 356 0.0543681447851778 368 5207356
SGTC_3238 9133470 49.47 µM 1.60285702299269 0.0662747197032164 no 357 0.0544831119719233 317 3534688
SGTC_2132 5317594 122.667 µM 1.60240033891331 0.0663286673680392 no 358 0.0545335549723987 314 794577
SGTC_227 fluconazole 33.516 µM 1.60146237786204 0.066439574470621 no 359 0.0546372732039905 446 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2895 9054447 58.44 µM 1.60045624435128 0.0665587020245978 no 360 0.0547487031638849 324 2697450
SGTC_2958 9077254 16.72 µM 1.59850756986472 0.0667898978337678 no 361 0.0549650310391279 342 16457351
SGTC_1820 st053765 18.6 µM 1.59782569831272 0.0668709434408997 no 362 0.0550408868643197 347 3690829
SGTC_371 0195-0006 7.36 µM 1.59731752652207 0.0669313929770925 no 363 0.0550974729724718 308 3928593
SGTC_1254 0550-0035 264 µM 1.59719196581195 0.0669463355522247 no 364 0.0551114615274442 404 15121435
SGTC_2350 9023895 38.85 µM 1.59700944276675 0.0669680616329943 no 365 0.0551318011855034 370 2997209
SGTC_534 k292-0788 63.4 µM 1.59648676476494 0.0670303072049427 no 366 0.055190079195207 409 4146317
SGTC_2082 5219693 150 µM 1.59562446436529 0.0671330961042586 no 367 0.0552863310702334 388 2834649
SGTC_1237 0330-0133 46.1 µM 1.59433739107461 0.0672867459426009 no 368 0.0554302435947502 347 X1237 YHR072W ERG7
SGTC_2277 7947813 106.88 µM 1.59214164304411 0.0675495000191612 no 369 0.0556764410191589 381 1246798
SGTC_636 0kpi-0074 126 µM 1.58884266699271 0.0679457613661319 no 370 0.0560479588740843 342 616434
SGTC_1648 st011736 69.8 µM 1.58698872901885 0.0681692363110937 no 371 0.0562575986789159 366 2855514
SGTC_1836 st055642 81 µM 1.58513771707706 0.068392924119846 no 372 0.0564675238572317 389 8571
SGTC_1274 0865-0114 173 µM 1.58139770705244 0.0688466179092634 no 373 0.0568935657118419 378 870624
SGTC_2241 6772625 37.8075 µM 1.58048456234612 0.0689577414615368 no 374 0.056997969759634 380 2285411
SGTC_144 4161-2749 112.381 µM 1.57805996713127 0.0692534692478942 no 375 0.0572759169845971 325 797501 YMR168C CEP3
SGTC_787 4152-0075 138 µM 1.5772857306894 0.0693481083662028 no 376 0.0573648971071141 385 9566539
SGTC_1866 st057638 64 µM 1.57712817243139 0.0693673797598927 no 377 0.0573830180052667 357 688802
SGTC_2232 chlorophetanol 41.5365 µM 1.56826464962618 0.0704581591370861 no 378 0.058409691113455 523 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3234 9132280 49.47 µM 1.56617553624347 0.0707171636703479 no 379 0.0586537641127302 403 17612295
SGTC_1402 3909-7673 35.9 µM 1.56418906190469 0.0709641211955811 no 380 0.0588865875876059 371 5328014
SGTC_618 k072-0232 33.2 µM 1.56347504023917 0.0710530496856614 no 381 0.058970451002415 350 5872756 YGL099W LSG1
SGTC_973 1325-0077 65.9 µM 1.56295498172777 0.0711178747053685 no 382 0.0590315919750679 419 2835149
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.56257716685343 0.0711649976050828 no 383 0.0590760411721818 451 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2817 7995342 71.43 µM 1.55633530265852 0.0719469873329612 no 384 0.0598141904541011 336 18879975
SGTC_2435 5706476 10.6 µM 1.55393573308314 0.0722493561319131 no 385 0.0600998735740299 418 5725375
SGTC_2780 5215298 71.43 µM 1.55322614343437 0.072338957557328 no 386 0.0601845588267068 421 2834131
SGTC_2379 9035213 200 µM 1.5513192107372 0.0725801719613145 no 387 0.0604126026369799 418 646551
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.55084648992828 0.0726400632069355 no 388 0.0604692382183509 436 6708561
SGTC_1529 apigenin 74 µM 1.55051935598454 0.0726815315147699 no 389 0.0605084556922487 427 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1400 3771-8998 51.5 µM 1.54869884983607 0.0729126346121146 no 390 0.0607270652548123 350 670767
SGTC_345 1362-0200 395 µM 1.54568716161363 0.0732961860471805 no 391 0.0610900696589584 370 1419823
SGTC_2269 7935389 174.42 µM 1.54078228986277 0.0739241436540066 no 392 0.0616848905682043 391 97605
SGTC_701 4424-0219 185 µM 1.53471972166777 0.0747059891329804 no 393 0.0624263446716053 439 2911779
SGTC_1249 0481-0015 10.2 µM 1.53273357854973 0.0749634951464208 no 394 0.0626707560727933 354 4227577
SGTC_551 k048-0028 34.9 µM 1.53237862242288 0.0750095868900466 no 395 0.062714514821743 427 6836383
SGTC_1786 berberine 21.6 µM 1.53185936277465 0.0750770526989286 no 396 0.0627785716878565 423 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1265 0819-1001 68.8 µM 1.53068119698662 0.0752302997563198 no 397 0.0629241015495742 394 3106768
SGTC_2666 tannic acid 100 µM 1.52983468389757 0.0753405550439988 no 398 0.0630288270336019 438 16134267 A thiamine antagonist.
SGTC_2045 5106652 78.05 µM 1.52977438142577 0.0753484139213632 no 399 0.063036292467902 379 673349
SGTC_3081 9117243 49.47 µM 1.52863030405749 0.0754976334152371 no 400 0.0631780595489459 381 45595589
SGTC_1579 chlormadinone acetate 49.4 µM 1.52812398264171 0.0755637436429723 no 401 0.0632408790035126 406 45114258 A steroidal progestin.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.52489349200262 0.0759865867430518 no 402 0.0636428326955284 421 107982 A Capsaicinoid.
SGTC_2007 4011539 71.82 µM 1.51970794848898 0.0766690928158898 no 403 0.0642921965126978 433 45595301
SGTC_2789 5281112 71.43 µM 1.51381588752911 0.0774502354072389 no 404 0.0650362709752182 431 765948
SGTC_2496 diffractaic acid 79.83 µM 1.51232703723399 0.0776485737534311 no 405 0.0652253430797626 448 94870 An apoptosis inducer which activates caspases.
SGTC_2235 salicylic acid 500 µM 1.49193681648873 0.0804038113502531 no 406 0.0678578549628256 373 338 A COX inhibitor and kinase inhibitor.
SGTC_2766 oltipraz 83.91 µM 1.48226648670795 0.0817360638002403 no 407 0.0691347009166958 422 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_324 1315-0088 19.6 µM 1.48117965214024 0.0818868278819013 no 408 0.0692793534554553 364 6787421
SGTC_3274 9138298 49.47 µM 1.47441607786957 0.0828297745159512 no 409 0.0701847990806442 457 17015756
SGTC_3286 9117135 37.221 µM 1.4737851223632 0.0829181543577143 no 410 0.0702697276500951 438 3438150
SGTC_3177 9107506 49.47 µM 1.47321169665651 0.0829985373427695 no 411 0.0703469810623139 358 8897194
SGTC_1476 4112-3294 3.34 µM 1.47045858896328 0.0833852852062382 no 412 0.0707187966927105 408 704369
SGTC_3350 9150499 3.57 µM 1.46674923889149 0.0839085029449009 no 413 0.0712221414610506 505 4910996 YPR165W RHO1
SGTC_81 0411-0046 9.971 µM 1.46578338704599 0.0840451436817465 no 414 0.0713536541728501 406 12925265
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.4640850965222 0.0842858088163901 no 415 0.0715853494129877 470 1377
SGTC_1016 4226-1401 38 µM 1.46268797331545 0.0844841829155096 no 416 0.0717763892607898 454 2901613
SGTC_2747 doxorubicin 7.63 µM 1.46265944161018 0.084488237708908 no 417 0.0717802946998567 266 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2701 st077767 14.721 µM 1.45472204014095 0.085621943100802 no 418 0.0728731141841453 505 5721188
SGTC_203 k066-0004 30.888 µM 1.45411543894417 0.085709050702452 no 419 0.0729571519353603 549 6795412
SGTC_14 0354-0009 295 µM 1.45273151966156 0.0859080290663321 no 420 0.0731491559848951 447 1713507
SGTC_741 4582-0002 126 µM 1.45149758685288 0.0860857338980019 no 421 0.0733206768552452 457 2912688
SGTC_685 1278-0033 54.9 µM 1.44632928548772 0.0868330357655289 no 422 0.074042432742218 489 3590572
SGTC_2823 7987624 58.44 µM 1.44496851869035 0.0870305973126991 no 423 0.0742333642600311 501 2239440
SGTC_475 α-linolenic acid 10 µM 1.44484199068985 0.0870489841982312 no 424 0.0742511367099597 472 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2659 sanguinarine 24.21 µM 1.44319547301297 0.0872885186181327 no 425 0.0744827072135265 454 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1702 st027038 51 µM 1.43401039910465 0.0886337937799222 no 426 0.0757846476408999 478 5521182
SGTC_1667 st014849 34.6 µM 1.42170760780698 0.0904598141984489 no 427 0.0775555753211659 471 5348460
SGTC_1379 2144-0755 36.5 µM 1.42095784859907 0.0905719922518428 no 428 0.0776645069282581 509 5392327
SGTC_1685 st024049 53.0905 µM 1.41691573489287 0.0911785479300913 no 429 0.0782537827580803 418 1941139
SGTC_1835 st008666 49.2 µM 1.41685505963459 0.0911876756921771 no 430 0.078262654004975 397 690455
SGTC_3189 9110682 49.47 µM 1.41252520949337 0.0918407931329965 no 431 0.0788976866274582 468 17122418
SGTC_512 prima-1 270 µM 1.41159633917862 0.091981354819809 no 432 0.0790344254661693 495 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_72 0744-0168 198.391 µM 1.40771632909362 0.0925702217114857 no 433 0.0796075423190479 467 677577
SGTC_2411 st077133 39.94 µM 1.40460100624213 0.0930450473919429 no 434 0.0800699786259448 550 1403142 YNL221C POP1
SGTC_849 0386-0493 241 µM 1.40420587250519 0.0931054005905791 no 435 0.0801287768261092 450 726119
SGTC_1038 k292-0204 154 µM 1.40202595226958 0.0934388843992356 no 436 0.0804537485232299 446 4454212
SGTC_2324 6149169 200 µM 1.39920292721857 0.0938720602909912 no 437 0.0808760695213134 438 2888231
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.39798270287734 0.0940597543497335 no 438 0.0810591307357517 401 61125 An anti-inflammatory.
SGTC_3060 1327-0027 12.5 µM 1.39678027916425 0.0942449810594135 no 439 0.0812398271887485 442 16000455 YPR107C YTH1
SGTC_2377 9073351 62.6 µM 1.39624860809082 0.0943269677703018 no 440 0.0813198218739475 478 7337946 YHR072W ERG7
SGTC_1247 0448-0043 5.84 µM 1.39583042616804 0.0943914907548962 no 441 0.0813827828348959 538 3089013 YGL099W LSG1
SGTC_2068 5226020 147 µM 1.39578772035368 0.0943980818393077 no 442 0.0813892146389097 536 1810509
SGTC_1146 3579-1023 7 µM 1.39062757670047 0.0951969826702128 no 443 0.0821691947593382 547 X1146
SGTC_1571 st070080 73.4 µM 1.38506315976751 0.0960640408332568 no 444 0.0830165777476126 487 4315245
SGTC_1899 st063254 59.6 µM 1.38385472733618 0.0962531061510087 no 445 0.0832014707933552 423 3093813
SGTC_796 1234-0020 70.7 µM 1.38304353011584 0.0963801753597902 no 446 0.0833257594768126 501 46495034
SGTC_2460 5552655 174.22 µM 1.37730351505815 0.097282838391686 no 447 0.0842092144668577 494 5401989
SGTC_1010 4112-3296 15.2 µM 1.37418090647377 0.0977764908890384 no 448 0.0846927634070511 534 704384
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.36782734562734 0.0987865886112065 no 449 0.0856830629712595 514 5282309
SGTC_2919 7978188 46.38 µM 1.36672564673275 0.0989625122654622 no 450 0.0858556579556786 518 2980291
SGTC_266 formosanin C 406 nM 1.36106044899022 0.0998707738889106 no 451 0.086747293594948 533 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1258 0671-0043 57.1 µM 1.36101665010947 0.0998778194967563 no 452 0.0867542138786313 519 4298767
SGTC_2405 ticlatone 3.52 µM 1.35440882567199 0.100944935278578 no 453 0.0878029917240852 489 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_107 0358-0022 2.6945 µM 1.35370781612963 0.101058629071057 no 454 0.0879148067570956 355 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_606 k015-0008 38.6 µM 1.35051848271162 0.101577072043668 no 455 0.0884248645544628 551 1970475
SGTC_2523 spermine 47.74 µM 1.34728373919089 0.10210487232756 no 456 0.0889444335648382 491 1103 A DNA binding polyamine.
SGTC_39 0986-0283 58.349 µM 1.34584970674402 0.102339494999359 no 457 0.0891754955975865 589 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2151 5563267 85.4165 µM 1.34454028479238 0.102554072331332 no 458 0.0893868693271434 541 5310824
SGTC_639 0833-0042 114 µM 1.33966506810637 0.103355858552491 no 459 0.0901771295553957 557 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1206 3978-0017 132 µM 1.33901973711496 0.103462330874826 no 460 0.0902821238272606 481 3873677
SGTC_655 k060-0012 42 µM 1.33655862935267 0.103869116578631 no 461 0.0906833753839936 525 5994525
SGTC_373 0844-0104 25.9 µM 1.33529965076658 0.10407765555089 no 462 0.0908891464478361 556 5375804
SGTC_1406 3909-7906 11.9 µM 1.33513493225848 0.104104962195366 no 463 0.0909160941185945 526 X1406
SGTC_1002 4049-0206 172 µM 1.33111452958855 0.104773066376378 no 464 0.0915756644166202 575 4662749
SGTC_2667 digitoxin 100 µM 1.33102461028051 0.104788044441366 no 465 0.0915904566320497 419 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_960 1222-0186 7.7 µM 1.32510541765283 0.105777431040072 no 466 0.0925680947502143 545 3126296
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.3241543431542 0.105937029712558 no 467 0.09272589527465 576 23665772 A membrane-active detergent.
SGTC_1569 carminic acid 40.6 µM 1.32288046368713 0.106151070443154 no 468 0.092937566570654 544 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1723 st034307 2.5525 µM 1.32270740516385 0.1061801722984 no 469 0.0929663499868096 517 867466
SGTC_1270 0831-1170 17.3 µM 1.32005287397635 0.106627285780271 no 470 0.0934086826762937 581 6764716
SGTC_916 4466-0038 42 nM 1.31948209235942 0.106723602109486 no 471 0.0935039965187353 674 5722064 YGL116W CDC20
SGTC_1353 1498-1206 8.11 µM 1.3160968890196 0.107296127587677 no 472 0.0940707625084583 610 6756808
SGTC_1074 carmofur 3.8 µM 1.31244290509466 0.107916592164942 no 473 0.0946853691942227 583 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1320 1313-0481 95.3 µM 1.31048654008663 0.108249852758958 no 474 0.0950156473398263 539 6813365 YLR208W SEC13
SGTC_1077 5-fluorocytosine 377 nM 1.3102251815184 0.108294430391434 no 475 0.09505983468841 507 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_792 4534-1957 155 µM 1.30854647720063 0.108581067188039 no 476 0.0953440106021677 535 1717904
SGTC_396 dithiazanine 1.25 µM 1.30692485945625 0.108858474337057 no 477 0.0956191161386557 505 10578 An antihelmenthic.
SGTC_856 0433-0016 11.3 µM 1.30596079528596 0.109023636331762 no 478 0.0957829450930678 573 3911780
SGTC_67 0335-0847 266 µM 1.30548435903474 0.109105325125686 no 479 0.0958639848351932 696 4552207 YOR254C SEC63
SGTC_297 0986-0032 24 µM 1.30417105611387 0.109330729097205 no 480 0.0960876330618431 489 2847425
SGTC_3320 9137005 35.139 µM 1.3019060524168 0.109720260382242 no 481 0.0964742516122953 523 4908713
SGTC_1606 st000094 49.2 µM 1.29785588869456 0.110419281934543 no 482 0.0971684301968946 568 1242210
SGTC_154 3389-1638 511.116 µM 1.29784292317071 0.110421524781831 no 483 0.0971706582958815 478 5238686
SGTC_2137 5261020 140 µM 1.29632455353839 0.110684406604144 no 484 0.0974318463986644 522 763655
SGTC_1832 st054113 55 µM 1.28964196493909 0.11184672236536 no 485 0.0985874990954892 507 1251267
SGTC_1318 1280-3875 124 µM 1.28879002433307 0.111995527121583 no 486 0.0987355475121049 580 373245
SGTC_1952 st077036 64.1 µM 1.28672156400426 0.112357404987321 no 487 0.0990956770875354 567 2937007
SGTC_1570 verbenone 133 µM 1.27949175765146 0.113628823775866 no 488 0.100361970138704 579 29025 A natural terpanoid with antifungal properties.
SGTC_1015 4130-4525 82 µM 1.27850007760214 0.113804015342822 no 489 0.100536578710923 572 1363237
SGTC_366 0181-0206 4.31 µM 1.27614065682101 0.114221607510493 no 490 0.100952900873248 589 274874
SGTC_2103 5378138 10 µM 1.27384572401568 0.114628831810345 no 491 0.101359048468897 627 244142
SGTC_2335 9018011 154.17 µM 1.27253073005019 0.114862635980168 no 492 0.101592306375437 610 6458208
SGTC_2678 equilin 100 µM 1.27183800343427 0.114985938178347 no 493 0.101715341560931 582 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2130 NSC 7 2.4545 µM 1.27071232463575 0.115186504622414 no 494 0.101915504701548 605 21448
SGTC_1050 3232-1156 69.3 µM 1.26826205096469 0.115623938742433 no 495 0.102352192168036 578 700529
SGTC_1581 himbacine 57.9 µM 1.26770212553183 0.115724064635879 no 496 0.10245217273192 587 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1516 st013856 110 µM 1.26551288461912 0.116116135869583 no 497 0.102843766285604 545 5281404 A mutagen and neurotoxin.
SGTC_1849 st056239 19.2 µM 1.26267018216105 0.116626641196929 no 498 0.10335386711668 590 5393181
SGTC_3063 1327-0034 4 µM 1.26040791092306 0.117034045837049 no 499 0.1037611246601 546 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_365 0121-0052 13.6 µM 1.25817599289505 0.117436971514846 no 500 0.104164057571582 643 3101739
SGTC_24 0417-1663 219 µM 1.2556216458962 0.117899309130086 no 501 0.104626589780552 559 4329390
SGTC_2862 9027634 71.43 µM 1.25429166413942 0.118140545417253 no 502 0.104868006341625 544 5012562
SGTC_2010 4012422 159 µM 1.253839721182 0.118222599665719 no 503 0.104950134182017 599 952393
SGTC_1903 st060211 78.3 µM 1.25259306202227 0.118449150550779 no 504 0.105176920540387 621 688960
SGTC_3249 9135183 49.47 µM 1.2517919322333 0.118594898843534 no 505 0.105322845340992 620 4902779
SGTC_3162 9099653 49.47 µM 1.24708208520217 0.119454316572173 no 506 0.106183700507672 520 25237511
SGTC_2179 6298986 200 µM 1.24514112120915 0.119809764653212 no 507 0.106539940458151 547 738374
SGTC_1932 st074806 40.9 µM 1.24504687995838 0.119827041985172 no 508 0.106557259211514 639 17251235
SGTC_3038 9091290 49.47 µM 1.24377967586787 0.120059530264751 no 509 0.10679033124198 592 25236843
SGTC_3075 9116269 49.47 µM 1.23889758321276 0.120958197076846 no 510 0.10769171441015 592 17015205 YNL244C SUI1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.23786472230468 0.121148925050383 no 511 0.10788311247382 608 688664
SGTC_1539 benzyladenosine 56 µM 1.23782543605099 0.121156183819143 no 512 0.107890397389939 563 92208 A nucleotide analog.
SGTC_2206 7254556 146.969 µM 1.23213236344392 0.122211306674766 no 513 0.108949821892145 542 4398905
SGTC_3305 9127027 53.8275 µM 1.23196269900657 0.122242850035735 no 514 0.108981509113768 586 41905295
SGTC_2910 7948405 25.97 µM 1.23183485059279 0.122266622897856 no 515 0.109005390980724 535 2971328
SGTC_929 2805-0021 398 µM 1.23123335356753 0.122378512231839 no 516 0.109117800086022 572 3098024
SGTC_706 4262-0057 46.9 µM 1.23079982877611 0.122459200240118 no 517 0.109198869806454 584 883298
SGTC_1942 st076330 65.2 µM 1.23040634417744 0.122532468246476 no 518 0.109272489415658 585 24208414
SGTC_622 1348-1566 26.3 µM 1.23010611689343 0.122588392145782 no 519 0.109328684881434 660 7340407
SGTC_2725 haloperidol 53.21 µM 1.22847525064874 0.122892489486324 no 520 0.10963430727193 597 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_196 k015-0023 18.111 µM 1.22790150048181 0.122999598732164 no 521 0.109741973093266 631 5211998
SGTC_2296 7971656 126.45 µM 1.22451262299271 0.123633578502563 no 522 0.110379453696343 595 666570
SGTC_518 1021-0119 62.6 µM 1.22132174585182 0.12423260538054 no 523 0.11098211152107 584 1097762
SGTC_608 k048-0125 159 µM 1.21771751851283 0.124911669223541 no 524 0.111665668735205 619 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2906 7926292 26.41 µM 1.21596499157737 0.125242793957645 no 525 0.111999129161606 598 2966319
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.21318792022662 0.125768751602715 no 526 0.112528990748864 576 279621
SGTC_1211 1056-0033 32.3 µM 1.21255580605585 0.125888684499986 no 527 0.112649847071547 628 6741922
SGTC_1404 3909-7820 48.3 µM 1.2111411310088 0.126157383927692 no 528 0.112920660001058 604 23741373
SGTC_387 norethindrone acetate 66.7 µM 1.21077001334292 0.12622793912588 no 529 0.112991780381579 566 541197
SGTC_2625 euphol 100 µM 1.2095764932785 0.126455032143395 no 530 0.113220721329258 662 6708538 A triterpene alcohol.
SGTC_1200 1643-0193 18.4 µM 1.20927257625064 0.126512904373518 no 531 0.113279071503531 643 5403974
SGTC_1296 1068-0102 11.9 µM 1.20670861156306 0.127001871903909 no 532 0.113772190738466 615 767053
SGTC_965 1291-5240 308 µM 1.20275623618914 0.127758193696838 no 533 0.114535332410484 641 2834598
SGTC_614 0462-0418 107 µM 1.20248939072551 0.127809369498357 no 534 0.114586987067445 549 5188303
SGTC_2999 9069765 71.4286 µM 1.19960163158541 0.128364097256201 no 535 0.11514704630356 649 2097066
SGTC_607 4491-0986 66.8 µM 1.19748185451062 0.128772360916812 no 536 0.115559397993812 650 698981 YDR232W HEM1
SGTC_692 k241-0027 77.8 µM 1.19650574277662 0.128960660138976 no 537 0.11574962943995 609 3600480
SGTC_2745 rifampicin 24.3 µM 1.19646917586991 0.128967717876382 no 538 0.115756760172633 472 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3205 9113483 49.47 µM 1.19412340996519 0.129421031356631 no 539 0.116214848578105 662 17018033
SGTC_446 go6976 132 µM 1.19294193646284 0.129649765798063 no 540 0.116446056879011 594 3501 A protein kinase C inhibitor.
SGTC_2614 arthonioic acid 13.39 µM 1.19254490624487 0.129726694061648 no 541 0.116523826853801 567 6710684
SGTC_759 3486-0358 89.3 µM 1.19174619881863 0.129881546733384 no 542 0.116680388630686 681 875103
SGTC_593 1203-0218 61.7 µM 1.18795096765003 0.130619111289778 no 543 0.117426363932941 661 3666956
SGTC_84 0443-0269 128.823 µM 1.16932217150672 0.134281391289535 no 544 0.121136926779364 675 6150058
SGTC_2561 acetosyringone 100 µM 1.16713614780909 0.134715725333002 no 545 0.121577695971235 725 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_300 r073-0011 5.04 µM 1.16417430975099 0.135305739920963 no 546 0.122176689540282 721 2735780
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.16236732392647 0.135666570261552 no 547 0.122543145175456 641 6312947
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.16209635695448 0.135720735438353 no 548 0.122598163537303 669 688667
SGTC_2245 6637752 200 µM 1.16172284173246 0.135795423865085 no 549 0.122674032165569 560 681890
SGTC_1613 st002381 52.1 µM 1.16014365839866 0.136111509782945 no 550 0.122995160748379 636 551167
SGTC_1896 st058441 89 µM 1.15890493726259 0.136359801689374 no 551 0.123247468095227 586 688759
SGTC_2449 5812982 45.77 µM 1.1567718476217 0.136788088566669 no 552 0.123682793323605 607 776185
SGTC_1926 methyl fluorone black 53.6 µM 1.15318320533245 0.137510697790916 no 553 0.124417597708075 596 72721 Reacts with homocysteine.
SGTC_230 MPP+ 141.667 µM 1.15265628991775 0.137617016515865 no 554 0.124525744504528 629 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2035 5154463 94.595 µM 1.15122776233737 0.137905540858776 no 555 0.124819273318327 669 2769623
SGTC_581 0958-0271 211 µM 1.15090404604883 0.137970980195771 no 556 0.12488585653806 726 4591145
SGTC_202 3594-0513 34.79 µM 1.14882612478212 0.138391536856224 no 557 0.125313842308929 638 708429
SGTC_2864 9034755 47.6 µM 1.14875757640659 0.13840542543642 no 558 0.125327978522131 642 4930451
SGTC_2160 5660466 132.927 µM 1.14713773338415 0.138733898151081 no 559 0.125662350512267 638 2859134
SGTC_2307 7538926 6.34 µM 1.14647593896437 0.138868249867316 no 560 0.125799138675638 683 96582
SGTC_501 nsc-95397 161 µM 1.14640137768165 0.138883392198321 no 561 0.125814556465712 639 262093
SGTC_3155 9099265 49.47 µM 1.1462478158139 0.138914581961374 no 562 0.12584631415758 621 25236499
SGTC_2837 9008476 45.46 µM 1.14606152638511 0.138952425381138 no 563 0.125884847647655 657 2992805
SGTC_3100 9120536 49.47 µM 1.1459349109155 0.138978150451615 no 564 0.125911042428945 540 16421196
SGTC_2149 5554786 194.827 µM 1.14336303176307 0.139501393332964 no 565 0.126443947346363 702 745063 YPR165W RHO1
SGTC_2608 thymoquinone 42.66 µM 1.14321007689325 0.139532553804874 no 566 0.126475689713898 620 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2918 7977171 22.06 µM 1.14219831357848 0.13973879279068 no 567 0.126685798407362 646 2236483
SGTC_1665 st014639 11.4 µM 1.14188323774573 0.139803060503553 no 568 0.126751278505429 713 981133 YIL048W NEO1
SGTC_862 0452-0056 10.2 µM 1.13999150825184 0.140189349182502 no 569 0.127144919468654 649 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_507 nimesulide 162 µM 1.13912075592567 0.140367399105806 no 570 0.127326395750717 687 4495 A COX2 inhibitor.
SGTC_1376 2910-0861 41.3 µM 1.13679280956977 0.140844167322381 no 571 0.127812454976041 690 1112859
SGTC_757 1066-0008 322 µM 1.13481201420335 0.141250702464048 no 572 0.128227045646829 707 6842497
SGTC_2863 9028737 58.44 µM 1.13136575139755 0.141959902089252 no 573 0.128950590166053 649 6460917
SGTC_589 1227-0070 34.1 µM 1.13097451899385 0.142040565140593 no 574 0.129032908207351 689 2841384
SGTC_3111 9122088 49.47 µM 1.12961716225107 0.142320661147671 no 575 0.129318788069597 546 16876704
SGTC_1394 3474-0001 65.7 µM 1.12915731210554 0.142415637757325 no 576 0.129415738940951 595 5017666 YIL048W NEO1
SGTC_1653 st012112 65 µM 1.12799361443675 0.142656177245834 no 577 0.129661307962344 646 720429
SGTC_49 0717-0965 32.132 µM 1.12623533018523 0.143020140218307 no 578 0.130032961377477 686 5889349 YGL099W LSG1
SGTC_1092 toremifene 6.32 µM 1.12146402761508 0.144010953927584 no 579 0.131045197644489 731 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2402 5553605 200 µM 1.12039091879344 0.144234432982293 no 580 0.131273606542403 718 6758546
SGTC_1331 1472-0049 76.2 µM 1.11875525387095 0.144575516049915 no 581 0.131622282927365 661 24051409
SGTC_3097 9117246 49.47 µM 1.11710422573828 0.144920353438796 no 582 0.131974881960249 679 16423892
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.11690130059169 0.144962775015251 no 583 0.132018264239944 653 6708760
SGTC_594 1487-1584 10.8 µM 1.1167332469454 0.144997913019434 no 584 0.132054198972454 686 5013332
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.11656105552141 0.145033922129827 no 585 0.132091025477254 613 77254
SGTC_3183 9108214 49.47 µM 1.1160263165514 0.145145786478631 no 586 0.132205435008927 575 4974831
SGTC_1226 3909-7979 35.4 µM 1.11586151978205 0.145180272726222 no 587 0.132240707700923 745 6615510
SGTC_1455 4262-0120 131 µM 1.11395651024409 0.145579325408508 no 588 0.132648922188865 725 1529587
SGTC_1014 4130-3005 69.3 µM 1.11225372567657 0.145936640629734 no 589 0.133014536932052 701 743608
SGTC_118 0083-0097 135.343 µM 1.11169960805625 0.146053044601271 no 590 0.133133664198936 907 5207356
SGTC_1672 st016598 6.51 µM 1.10998058249072 0.14641455862482 no 591 0.133503696948688 682 4665860 YNL267W PIK1
SGTC_1156 4092-0367 4.88 µM 1.10955137911085 0.146504914473282 no 592 0.133596196342218 703 1357585
SGTC_62 0180-0423 3.232 µM 1.10912432233151 0.146594855560526 no 593 0.133688276843843 676 30102 YGL099W LSG1
SGTC_565 1418-0001 44.5 µM 1.10810530227011 0.146809617854392 no 594 0.133908170664407 745 2862145
SGTC_2844 9010103 25.97 µM 1.10140486795627 0.148227014558892 no 595 0.135360243863104 689 2480525
SGTC_514 4466-0038 2.65 nM 1.10066900667351 0.148383233299609 no 596 0.135520370011069 765 5722064
SGTC_975 1335-0046 28.5 µM 1.09871772600989 0.148798010944077 no 597 0.135945604151795 692 16486740
SGTC_1463 k081-0032 34.1 µM 1.09758347845792 0.149039470189145 no 598 0.13619320522259 584 977755
SGTC_2639 lactacystin 53 µM 1.09729012597261 0.149101961805452 no 599 0.13625729293219 738 3870 A proteasome inhibitor.
SGTC_2765 myclobutanil 7.74 µM 1.09721949249221 0.149117011165442 no 600 0.136272727067998 702 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_797 k781-0471 270 µM 1.09666935178138 0.149234260353041 no 601 0.136392979366133 739 23738129
SGTC_1446 4239-0190 62 µM 1.09590015107652 0.149398300065901 no 602 0.136561236484134 753 1340085
SGTC_105 0111-0055 734.78 µM 1.09558468169802 0.149465611846574 no 603 0.136630284170063 618 5179370
SGTC_353 1988-1175 58.3 µM 1.09499520481581 0.149591442920397 no 604 0.136759368633197 653 2788357
SGTC_3271 9137798 49.47 µM 1.09343156023615 0.149925564405603 no 605 0.137102181482043 634 6498326
SGTC_1052 3253-3998 198 µM 1.09317245347299 0.149980978685156 no 606 0.137159044604411 742 5450317
SGTC_195 4234-0266 16.654 µM 1.09232583382147 0.150162137548132 no 607 0.137344954600986 762 2303354
SGTC_258 haloperidol 50.781 µM 1.08673674758529 0.151361743575198 no 608 0.138576584364568 697 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2740 felodipine 17.08 µM 1.08566853411916 0.151591741593978 no 609 0.138812833347437 653 3333 L-type calcium channel blocker
SGTC_1161 k007-0610 110 µM 1.08385744551205 0.15198221931871 no 610 0.139214005042444 812 5843850
SGTC_1127 asiatic acid 681.4 nM 1.08362031348442 0.152033395324467 no 611 0.1392665901815 697 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_781 4335-2806 94.4 µM 1.07986934110889 0.152844423556949 no 612 0.140100183800616 819 845254
SGTC_1107 amlodipine 47 µM 1.07706055946299 0.153453608238482 no 613 0.140726605813679 721 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_807 1315-0151 48 µM 1.07587161463426 0.15371195720598 no 614 0.140992339160939 809 4011080
SGTC_2023 5144124 124 µM 1.07172882149389 0.154614404168694 no 615 0.141920925749651 725 2830192
SGTC_577 r071-0003 38.6 µM 1.06948262091689 0.155105167131493 no 616 0.142426127890352 862 4568517 YMR134W ERG29
SGTC_3174 9107204 49.47 µM 1.06625275354895 0.155812648103719 no 617 0.143154700420698 708 3938802
SGTC_2486 5283202 22.39 µM 1.06292036891178 0.156544811405876 no 618 0.143909032496031 690 1377751
SGTC_635 k038-0028 24.7 µM 1.06075000749881 0.157022880920322 no 619 0.144401763547573 758 4035102
SGTC_1169 aniline yellow 25.8 µM 1.05993301086723 0.157203090807427 no 620 0.144587538198334 710 6051 A DNA damaging agent.
SGTC_2077 5212015 200 µM 1.05954226905753 0.157289327146442 no 621 0.14467644481282 692 780900
SGTC_1120 ficusin 1.78878 µM 1.05675211714921 0.157906014749067 no 622 0.145312366285595 763 6199 A DNA cross-linker.
SGTC_2873 9040596 71.43 µM 1.054066176305 0.15850116712998 no 623 0.145926310225336 739 6463863
SGTC_900 1112-0045 141 µM 1.05137989707056 0.159097864094436 no 624 0.146542072477183 609 56211 YIL048W NEO1
SGTC_124 0136-0217 7.121 µM 1.05096159569525 0.159190912654362 no 625 0.146638114291729 874 3976905
SGTC_1775 st081588 35.1725 µM 1.0503672724068 0.159323177489249 no 626 0.146774643288115 788 1426443 YGL099W LSG1
SGTC_63 0099-0242 26.702 µM 1.0498947920585 0.159428377878227 no 627 0.146883243138571 802 3898502 YLR359W ADE13
SGTC_259 usnic acid 108.925 µM 1.04256558222337 0.161066090141701 no 628 0.148574768305529 781 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1515 3460-0031 42.1 µM 1.04156799110809 0.161289847778671 no 629 0.148806007665559 693 2876596
SGTC_695 3505-6186 243 µM 1.0400367705147 0.161633691683983 no 630 0.149161408813876 776 1819379
SGTC_3168 9103419 49.47 µM 1.03949686206985 0.161755044916555 no 631 0.149286858344373 684 16649256
SGTC_3324 9138759 60.749 µM 1.03910571226904 0.161842999297099 no 632 0.149377787299931 755 45595710
SGTC_1462 k081-0014 26.5 µM 1.03195384120153 0.163456669366526 no 633 0.151046870797463 606 3270634
SGTC_3127 9126946 49.47 µM 1.03145887468377 0.163568733520843 no 634 0.151162842078401 678 27243249
SGTC_671 0560-0003 407 µM 1.02949066644218 0.164014844206076 no 635 0.151624581743237 751 3238678
SGTC_1372 2752-0194 270 µM 1.02774986846633 0.164410067665336 no 636 0.152033751670855 725 823334
SGTC_2016 5121758 140 µM 1.02676638542442 0.164633626218514 no 637 0.152265240642667 817 2795203
SGTC_867 0518-0118 155 µM 1.02506833933799 0.165020077699958 no 638 0.152665471596065 780 6848158
SGTC_408 cantharidin 100 µM 1.02436350987625 0.165180659357628 no 639 0.15283180529084 784 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2985 9022375 71.43 µM 1.02243813776177 0.165619833197315 no 640 0.153286788895812 785 4939335
SGTC_422 cantharidin 155 µM 1.02101399554622 0.165945162797898 no 641 0.153623903973985 775 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3272 9137413 49.47 µM 1.02034805024742 0.166097432283122 no 642 0.153781711188316 739 17614870
SGTC_397 arbidol 50 µM 1.02000076982835 0.166176874320654 no 643 0.153864047821907 826 131410 A RNA synthesis inhibitor.
SGTC_567 1080-0542 68.4 µM 1.01963477037557 0.166260624985423 no 644 0.15395085411874 727 5950415
SGTC_1910 st062352 60.4 µM 1.01826885992602 0.166573423244602 no 645 0.154275101436248 760 2245730
SGTC_2476 5806916 10.51 µM 1.01741630812401 0.166768852987655 no 646 0.15447771360989 764 2870194
SGTC_2450 5739737 12.93 µM 1.01616643518464 0.167055627626674 no 647 0.154775068487285 733 2262825
SGTC_1233 0325-0408 14.2 µM 1.01478386561473 0.167373218776239 no 648 0.155104433182419 790 12874
SGTC_2905 7799065 20.05 µM 1.01205260202083 0.168001762221981 no 649 0.15575645162838 757 1296806
SGTC_420 mitomycin C 81.9 mM 1.00904611525343 0.168695396677384 no 650 0.156476259233221 788 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3240 9133527 49.47 µM 1.00809798700264 0.16891452304242 no 651 0.156703711967417 768 17617455
SGTC_346 4513-0042 7.16 µM 1.00192467786119 0.170345733945035 no 652 0.158189986410987 819 2827372
SGTC_1162 k048-0130 20.1 µM 1.00067034273842 0.170637483909394 no 653 0.158493104979269 792 6797406
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.999697255158049 0.170864037777676 no 654 0.158728520409054 765 689007
SGTC_1588 farnesol 29.9 µM 0.999191298704398 0.170981910380004 no 655 0.158851015094024 797 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_680 0417-1641 114 µM 0.997723593307757 0.171324135736021 no 656 0.159206704657003 758 2835990
SGTC_2430 5571206 200 µM 0.994930260446844 0.171976666912747 no 657 0.159885092068056 900 1731771
SGTC_1679 SEC14.276 6.7 µM 0.99388868397618 0.172220387988311 no 658 0.160138532052861 835 1005053 YMR079W SEC14
SGTC_2947 9072639 7.68 µM 0.993720031450389 0.172259872136285 no 659 0.160179593861282 874 16488146
SGTC_2254 7938975 95.19 µM 0.992058827764921 0.172649094040822 no 660 0.160584414655498 875 2969277
SGTC_3321 9137793 26.8275 µM 0.991641341849345 0.172746999557303 no 661 0.160686257305983 811 4904192
SGTC_2887 9044784 58.44 µM 0.989720849558527 0.173197834045845 no 662 0.161155290611995 916 6465546
SGTC_3283 9109332 35.8195 µM 0.984594779844577 0.17440484120372 no 663 0.162411577418629 729 17027281
SGTC_927 2425-1185 123 µM 0.981377258610725 0.175165175971429 no 664 0.163203368233412 803 730375
SGTC_1659 st012954 42.1 µM 0.980857349833818 0.175288233008067 no 665 0.163331546147318 807 24207262
SGTC_1845 st056753 3.01 µM 0.977312112349919 0.176128814907754 no 666 0.164207329212462 821 5375839
SGTC_2934 9036370 36.88 µM 0.97721872310992 0.176150992094327 no 667 0.164230440329379 848 6462800
SGTC_262 fenpropimorph 62.5 µM 0.977131382445164 0.176171734522352 no 668 0.164252056508854 767 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3026 9090633 49.47 µM 0.97699331920228 0.176204526146877 no 669 0.16428622992069 825 25236842
SGTC_264 promethazine 12.5 mM 0.971922434407914 0.177411595972467 no 670 0.165544568991943 982 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2741 miltefosine 3.04 µM 0.971850680149914 0.177428713676845 no 671 0.165562419409928 737 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.970919999759389 0.177650831360696 no 672 0.165794058994003 786 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1184 1269-1718 139 µM 0.96961017304063 0.17796373381468 no 673 0.166120420090181 845 5403821
SGTC_450 aminopyrene 156 nM 0.96808734456773 0.178327956541811 no 674 0.16650037486204 837 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2087 5276107 200 µM 0.966206693132006 0.178778409348538 no 675 0.166970382188786 832 144405
SGTC_1530 rhein 70.4 µM 0.966059106507084 0.178813789518303 no 676 0.167007302814882 889 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_928 2764-0428 58.7 µM 0.959448490947787 0.180403035921124 no 677 0.168666428337877 870 662578
SGTC_2125 5246583 200 µM 0.957449963037902 0.180885237686674 no 678 0.169170095237619 931 835267
SGTC_2345 9052315 157.45 µM 0.956407075406644 0.181137184475566 no 679 0.169433305734554 805 6469265
SGTC_2840 9008771 71.43 µM 0.951574421207989 0.182307552254137 no 680 0.170656429494891 814 2992978
SGTC_2212 7123476 200 µM 0.951404033689338 0.182348902602057 no 681 0.170699656739385 783 1085715
SGTC_2473 5854593 8.94 µM 0.94994355182032 0.182703578736674 no 682 0.171070467864278 828 2872951
SGTC_1518 st038567 90.8 µM 0.946081470765923 0.183643553752595 no 683 0.17205351689102 859 77966
SGTC_1668 st014914 51.6 µM 0.945910410111844 0.183685257028771 no 684 0.172097141678231 875 2839556
SGTC_3151 9099821 49.47 µM 0.944728644996044 0.183973523469548 no 685 0.172398714469259 824 17174189
SGTC_2297 7971671 152.32 µM 0.942646247847839 0.184482164992003 no 686 0.172930937926179 846 909016
SGTC_969 1313-0238 134 µM 0.939589847256684 0.185230296663691 no 687 0.173713993021399 888 5212874
SGTC_563 tetrahydrosecaminediol 614 µM 0.93929254858586 0.185303168475343 no 688 0.173790281646304 909 334274 A psychoactive constituent of the cannabis plant.
SGTC_1847 st056231 15 µM 0.934800250955608 0.186406455380088 no 689 0.174945625119463 917 5393180
SGTC_1129 3453-1384 223 µM 0.934485422462377 0.186483928037606 no 690 0.175026776059252 899 1084452
SGTC_1366 1683-0113 21.9 µM 0.932260365831946 0.187032035939647 no 691 0.175600992618803 855 708623
SGTC_718 1130-0073 349 µM 0.930207108591136 0.187538706906246 no 692 0.176131931023556 886 6740020
SGTC_2682 pyrogallin 40.03 µM 0.929781828784455 0.187643756795032 no 693 0.176242028258662 940 822798 An ATP competetive kinase inhibitor.
SGTC_3016 9080866 49.47 µM 0.928209459753453 0.188032468889228 no 694 0.176649464190214 903 17066299
SGTC_1975 st070967 30.8 µM 0.927902050191145 0.188108522974941 no 695 0.176729190421884 943 261391
SGTC_294 k038-0071 157 µM 0.925659757045718 0.18866384744136 no 696 0.177311413903129 881 24152826
SGTC_175 3793-3120 23.7 µM 0.925246160307158 0.188766388754959 no 697 0.177418938681134 839 5322297
SGTC_482 fipronil 114 µM 0.924433978050789 0.188967849641257 no 698 0.177630205452607 870 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1714 st033236 13.627 µM 0.919809005613173 0.190117591742228 no 699 0.178836288215674 897 2916566
SGTC_2051 5263410 176 µM 0.915281206366153 0.191247331674129 no 700 0.180022011345947 920 227584
SGTC_2694 st077685 81.9 µM 0.914701826873426 0.191392190174513 no 701 0.180174092519906 850 2838096
SGTC_285 1486-1325 46 µM 0.914441354497204 0.191457336298414 no 702 0.18024249011628 911 22310230
SGTC_3232 9132874 49.47 µM 0.914020242902306 0.191562688249136 no 703 0.180353104525016 876 3784940
SGTC_1507 4075-3230 155 µM 0.913161513324791 0.191777631666873 no 704 0.180578801070302 838 659771
SGTC_3278 9139605 49.47 µM 0.912691419237003 0.191895360602981 no 705 0.180702429058398 868 7958859
SGTC_3304 9125678 46.087 µM 0.912513355670953 0.191939965851868 no 706 0.180749271071073 858 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2109 5483026 200 µM 0.910876392337619 0.192350325439285 no 707 0.181180252868011 900 759335
SGTC_1482 3346-2049 8.48 µM 0.910567102059072 0.192427919606401 no 708 0.181261755447051 882 3826804
SGTC_1111 tnp00062 510.699 nM 0.904975146476583 0.193834118010679 no 709 0.182739277051322 958 676306
SGTC_1295 1013-0063 9.78 µM 0.904840159216944 0.193868140243398 no 710 0.18277503644295 936 6826038
SGTC_1047 2043-3044 82 µM 0.903694221743689 0.194157109273579 no 711 0.183078781953923 939 669592
SGTC_629 3448-6466 76.7 µM 0.901923652462885 0.194604106116478 no 712 0.183548712944617 927 573744
SGTC_3096 9117468 49.47 µM 0.899590400711181 0.195194112875985 no 713 0.184169133763997 808 41316311
SGTC_3001 9076041 71.4286 µM 0.897161656868541 0.195809419966543 no 714 0.184816331029307 901 16004211
SGTC_1930 st074634 34.3 µM 0.896473903192826 0.195983871700119 no 715 0.184999856074086 912 684253 YOR116C RPO31
SGTC_3266 9136860 49.47 µM 0.892161703928113 0.197079827403062 no 716 0.186153132767005 889 4871271 YPR165W RHO1
SGTC_2981 9013952 38.96 µM 0.890230124129796 0.197571943412782 no 717 0.186671166235743 862 2996344
SGTC_3245 9134821 49.47 µM 0.889987809862608 0.197633731147374 no 718 0.186736215831341 954 17014901
SGTC_2436 5633522 8.09 µM 0.889451763697485 0.197770459093757 no 719 0.186880168002709 959 5724242
SGTC_212 3807-4682 38.772 µM 0.88867802593278 0.197967915201253 no 720 0.18708807197031 1064 3125501 YBL034C STU1
SGTC_1611 st001856 99.4 µM 0.887104313619455 0.198369890183958 no 721 0.187511370942016 879 647478
SGTC_3078 9116413 49.47 µM 0.886749674264486 0.198460544042733 no 722 0.187606843904398 926 17177322
SGTC_1709 st033179 39.1045 µM 0.886690037991594 0.198475790880602 no 723 0.187622901619241 937 573381
SGTC_1938 st074717 56.4 µM 0.885660131222624 0.198739212257406 no 724 0.187900349161547 861 17250979
SGTC_1738 st035555 74 µM 0.883226322591205 0.199362549617049 no 725 0.188557001129913 929 5331140
SGTC_3326 9140064 16.379 µM 0.882476492228126 0.1995548301262 no 726 0.188759593343013 937 1868434
SGTC_414 piperonyl butoxide 100 µM 0.882301812282065 0.199599639680215 no 727 0.188806808340162 911 5794 A potent inhibitor of cytochrome P450.
SGTC_282 k297-0036 65.7 µM 0.882149783797377 0.199638643524273 no 728 0.188847906699001 921 5061378
SGTC_26 0302-0163 425.158 µM 0.881023846023196 0.199927652529908 no 729 0.189152456719128 952 3100915
SGTC_734 2023-0417 80 µM 0.879156948882842 0.200407407215155 no 730 0.189658091650145 912 3935732
SGTC_1405 3909-7894 12 µM 0.879076031813609 0.200428216884361 no 731 0.189680026207587 946 7104060
SGTC_799 1310-0557 151 µM 0.877802650842831 0.200755866730104 no 732 0.190025412830952 927 5354492
SGTC_465 cgp-37157 41 µM 0.877210357684059 0.200908377391864 no 733 0.190186195624201 834 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_527 4476-4215 268 µM 0.875456938671243 0.201360275842564 no 734 0.190662665255444 912 4418754
SGTC_356 1634-0012 32.5 µM 0.874621785920103 0.201575728918524 no 735 0.190889864908731 984 735457
SGTC_783 0848-0141 92.7 µM 0.871501638953078 0.20238188685665 no 736 0.191740155682691 891 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2855 9016525 58.44 µM 0.869545651013458 0.202888240675988 no 737 0.192274374969803 973 43811474
SGTC_1091 telmisartan 47.6 µM 0.868007615564218 0.203286928548175 no 738 0.192695081798439 965 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1388 3346-4487 254 µM 0.866073209646079 0.203789026396419 no 739 0.193225007827407 1000 3345614
SGTC_1437 4092-1038 11.6 µM 0.863123967718555 0.204555958007708 no 740 0.194034655724417 998 3977136
SGTC_684 1140-0066 328 µM 0.86296355140418 0.204597722440811 no 741 0.194078753599705 983 6813534
SGTC_2746 daunorubicin 9.88 µM 0.862943982518389 0.204602817552983 no 742 0.194084133434735 835 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_645 0845-0943 5.41 µM 0.862742287981046 0.204655336760506 no 743 0.194139588146858 919 1885106
SGTC_1673 st016611 27.3 µM 0.86229466998728 0.204771920582791 no 744 0.194262692522445 974 5226799
SGTC_2669 eugenol 100 µM 0.859717946429876 0.205443805893436 no 745 0.194972269790576 924 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3214 9129694 49.47 µM 0.856438979272258 0.206300692770077 no 746 0.195877505882993 931 17158655
SGTC_394 menadione 8.33 µM 0.856074666512745 0.206396028572417 no 747 0.195978240179232 966 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1150 3909-7983 10.9 µM 0.854346866214541 0.206848526290584 no 748 0.196456413412938 962 23965914
SGTC_1273 0849-0096 14.1 µM 0.854302073896048 0.206860264860733 no 749 0.19646881919897 942 5286025
SGTC_572 0960-0087 17.7 µM 0.853671181472422 0.207025642571141 no 750 0.196643603079906 1041 6796365
SGTC_1664 st014217 9.02 µM 0.852472216389448 0.207340146374517 no 751 0.196976026600884 1069 3982782
SGTC_2017 5132927 60.65 µM 0.848885044804785 0.208282792511049 no 752 0.197972630665065 997 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3028 9087778 49.47 µM 0.847851635959333 0.208554822722284 no 753 0.198260301015846 995 17217395
SGTC_3296 9122258 64.045 µM 0.846155566162518 0.209001742766028 no 754 0.198732983013083 967 4730474
SGTC_2044 5102272 200 µM 0.845210107172565 0.209251119028895 no 755 0.19899677008694 909 592666
SGTC_2264 7948757 110.76 µM 0.843535347336539 0.209693286885898 no 756 0.199464552769462 966 2971411
SGTC_1416 3966-0321 25.3 µM 0.843343928022406 0.209743860121231 no 757 0.199518060847768 1001 582530 YLR208W SEC13
SGTC_87 0100-0052 35.5 µM 0.842926473519712 0.209854177021897 no 758 0.199634783256877 1123 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1862 st057513 3.81 µM 0.840213568942737 0.210571922195998 no 759 0.200394325899821 1015 5393163
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.839976552717908 0.210634697231939 no 760 0.200460766625598 1016 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2267 7931562 200 µM 0.838974346646067 0.210900258308361 no 761 0.20074185267839 886 934880
SGTC_2602 kawain 100 µM 0.837722569014251 0.211232225576491 no 762 0.201093267482756 1035 5369129
SGTC_2327 6189656 200 µM 0.836597616497754 0.21153082028022 no 763 0.201409392906923 990 5349088
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.835710256100994 0.211766525467855 no 764 0.201658962040147 1073 65057 A dermal irritant. YDR527W RBA50
SGTC_1325 1431-0015 227 µM 0.834303910275854 0.212140400850515 no 765 0.202054874463367 929 1103340
SGTC_825 1988-2224 89.6 µM 0.834236191666393 0.212158413496688 no 766 0.202073950238857 965 1180859
SGTC_3139 9095020 49.47 µM 0.832641968673062 0.212582723190957 no 767 0.202523341012561 825 25236292
SGTC_1277 0873-0036 22 µM 0.832512019542713 0.212617331575229 no 768 0.202559998302294 1030 5965735
SGTC_994 3910-0338 138 µM 0.831845820387448 0.212794807101902 no 769 0.202747988390938 1025 3479481
SGTC_2734 clemastine 41.6 µM 0.831454365439065 0.212899131066139 no 770 0.202858498937538 921 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.830596106631488 0.213127964149883 no 771 0.203100917463951 1085 91467 include heat shock
SGTC_41 0478-0632 82.643 µM 0.827408855186524 0.213979019124373 no 772 0.204002681591174 1059 3750424
SGTC_251 melphalan 456.522 µM 0.827380227063331 0.213986672315178 no 773 0.20401079209643 1098 460612 A DNA alkylator.
SGTC_334 1502-1024 68.5 µM 0.825538720805478 0.214479299089272 no 774 0.20453290451456 1022 3296216
SGTC_2982 9019404 25.97 µM 0.825292369852055 0.214545251129338 no 775 0.204602811334665 938 22333232
SGTC_2744 captopril 92.04 µM 0.825156728034872 0.214581569617764 no 776 0.204641308376494 973 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_548 1436-0017 110 µM 0.824957614416951 0.214634889337154 no 777 0.204697827406996 1066 9677137
SGTC_2700 st077718 96.8 µM 0.824903432978753 0.214649399667818 no 778 0.204713208586677 941 904970
SGTC_3314 9135860 59.4275 µM 0.824875197669535 0.214656961591787 no 779 0.204721224378471 1034 25252478
SGTC_1048 3161-0300 24.5 µM 0.824766504944292 0.214686072904933 no 780 0.204752083167799 1056 2165101
SGTC_976 1348-1067 47.6 µM 0.823271261239185 0.215086778776997 no 781 0.205176876325646 1100 5310671 YGL099W LSG1
SGTC_64 000l-0018 272.079 µM 0.822419792369054 0.215315155268431 no 782 0.205419009290576 1033 6811119
SGTC_697 0508-1955 564 µM 0.822405150843663 0.215319083571364 no 783 0.205423174397829 1045 6243113
SGTC_2192 5915882 198.485 µM 0.820693143543627 0.215778699638607 no 784 0.205910538626913 970 2876149
SGTC_1757 st041620 31.8375 µM 0.818167043943819 0.216457909473187 no 785 0.20663090524353 1025 5289815
SGTC_2739 tacrine 100.86 µM 0.817376839456102 0.216670630977604 no 786 0.206856553577058 1004 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_672 1441-0018 53.7 µM 0.815634419390193 0.217140114067018 no 787 0.207354628728201 980 251141
SGTC_1776 st049249 45.9 µM 0.815064225280217 0.217293876481409 no 788 0.207517774001353 1064 1822314
SGTC_557 1315-0110 16.2 µM 0.814179186003115 0.217532666688497 no 789 0.207771153717801 1070 6833801
SGTC_2375 9072683 200 µM 0.813612067635201 0.217685759049015 no 790 0.207933611222867 1101 16798029
SGTC_2029 5175081 200 µM 0.813447063058586 0.21773031334468 no 791 0.207980892741858 1084 1380876
SGTC_500 h-89 112 µM 0.812456447100093 0.217997908601232 no 792 0.208264883900132 1058 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1036 k216-0215 33.5 µM 0.811998924182706 0.218121563326563 no 793 0.20839612440215 996 622330
SGTC_892 0929-0076 29 µM 0.81074493444931 0.218460686320445 no 794 0.208756081472259 1045 5751038
SGTC_719 2810-4230 27.3 µM 0.809776799706809 0.218722711632504 no 795 0.209034234491563 1026 721079
SGTC_3071 9117417 49.47 µM 0.809634675826134 0.218761192628221 no 796 0.209075086208554 945 45595590 YGL055W OLE1
SGTC_1681 tripelennamine 100 µM 0.806207022995549 0.219690432015171 no 797 0.210061744970725 984 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3061 glucosamine 200 µM 0.805109543377997 0.219988437918956 no 798 0.210378234572617 1014 91431 and experimental redox chemotherapeutic
SGTC_3128 9127691 49.47 µM 0.804018927956873 0.220284809575358 no 799 0.210693021839386 922 41316314
SGTC_1346 1488-2224 62.4 µM 0.802740029989025 0.220632637922438 no 800 0.211062505371906 1049 3722427
SGTC_872 0588-0139 234 µM 0.801411087903349 0.220994410128307 no 801 0.211446849116283 1072 2047100
SGTC_225 nsc-122657 1.016 µM 0.797712867218509 0.222002946007936 no 802 0.212518567569529 926 275685
SGTC_66 0109-0187 42.4 µM 0.796501026939037 0.222333995784082 no 803 0.212870439430249 942 759417
SGTC_210 3551-0445 56.827 µM 0.796140006804395 0.222432673459584 no 804 0.21297533151039 1047 2865180 YOR207C RET1
SGTC_2994 9053520 71.4286 µM 0.795392958844237 0.222636943466163 no 805 0.213192477240928 1043 4647384
SGTC_3355 9151058 44.0485 µM 0.795042148110121 0.222732904731341 no 806 0.213294492545334 1080 17015728
SGTC_304 1310-0298 97 µM 0.791588941083315 0.223678757028045 no 807 0.214300198641666 1038 1550234
SGTC_1824 st053723 68.6 µM 0.789617526577673 0.224219760707712 no 808 0.214875584720338 1074 675225
SGTC_2368 9071271 200 µM 0.78469170108926 0.225574768538378 no 809 0.216317174850825 1048 27209959
SGTC_1396 3511-0007 98.6 µM 0.783987140768975 0.225768958779392 no 810 0.216523827889295 987 X1396
SGTC_379 3970-0972 5.9 µM 0.783655529633084 0.225860389839662 no 811 0.216621131541818 1034 2898042 YBL034C STU1
SGTC_869 0564-0080 44.1 µM 0.783030749242327 0.226032709730732 no 812 0.216804527667872 1024 6843321
SGTC_1704 st028805 70.8 µM 0.782652765466023 0.226136997029192 no 813 0.216915523442128 1044 2876101
SGTC_2062 5245942 200 µM 0.781605313757978 0.22642613535537 no 814 0.217223281540771 1161 1376160
SGTC_1227 3909-8010 46.6 µM 0.779634576407595 0.226970702734398 no 815 0.217802998912984 1020 15982272
SGTC_1073 triclabendazole 3.09 µM 0.777025457235121 0.22769280698477 no 816 0.218571875528742 1099 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1213 1315-0166 115 µM 0.77569292505348 0.228062099177419 no 817 0.218965159115969 978 768401
SGTC_576 1073-0113 22.7 µM 0.774302872523225 0.228447691024041 no 818 0.219375852692292 1265 5439563
SGTC_3354 9151612 71.43 µM 0.77329817786459 0.22872661491012 no 819 0.219672966951394 1091 27261949
SGTC_1637 st007924 17.4 µM 0.773250261495256 0.228739922254295 no 820 0.219687142834432 1059 683336
SGTC_159 3970-0959 50 µM 0.771721579829402 0.229164696122269 no 821 0.220139673334965 1212 6615653
SGTC_1290 0986-0249 10.2 µM 0.770903494799082 0.229392198523603 no 822 0.220382067751695 1078 53329
SGTC_1212 0520-0165 585 µM 0.770173130700933 0.229595413402894 no 823 0.220598600107657 1072 5403258
SGTC_2190 6049624 200 µM 0.770088043329306 0.229619094480932 no 824 0.220623834038129 1040 2265554
SGTC_756 0508-1999 28.3 µM 0.768833261510214 0.229968477707569 no 825 0.220996150270193 1072 6753853
SGTC_330 1488-0319 80.1 µM 0.766874290853515 0.230514530656821 no 826 0.221578130297321 1052 6846614
SGTC_284 0988-0104 32.6 µM 0.765950886868378 0.230772175837781 no 827 0.221852762882302 1118 4666532
SGTC_3322 9139058 2.11 µM 0.765909261349365 0.230783793842373 no 828 0.221865147441176 1068 4908926 YPR165W RHO1
SGTC_2349 9023730 187.07 µM 0.765197562864777 0.230982484933367 no 829 0.222076955353434 1070 4126287
SGTC_2972 9093619 59.92 µM 0.764381774970911 0.231210352993189 no 830 0.222319883139777 1063 25236256
SGTC_2459 5811157 9.22 µM 0.764351324220508 0.231218861005764 no 831 0.222328953790384 1098 2870684 YBR192W RIM2
SGTC_2292 7671323 168.05 µM 0.76369110866417 0.231403369754794 no 832 0.222525670295478 1069 937504
SGTC_3064 1327-0027 10 µM 0.761681236204026 0.231965568778648 no 833 0.22312513844458 978 16000455 YPR107C YTH1
SGTC_3152 9099253 49.47 µM 0.758863555326757 0.232755005933291 no 834 0.223967091038551 1132 25236131
SGTC_3010 9080089 71.4286 µM 0.757279349890535 0.233199511848665 no 835 0.224441259905311 1094 17027233
SGTC_3224 9130643 49.47 µM 0.751344606400388 0.234868899855123 no 836 0.226222645278883 1121 17644395
SGTC_2390 9097792 176.6 µM 0.749239410414297 0.235462655013661 no 837 0.22685645968957 1062 4497149
SGTC_673 1082-0474 110 µM 0.746793578376141 0.23615352303297 no 838 0.227594086238295 1171 3098046
SGTC_1550 gossypolone 36.6 µM 0.746775783055852 0.236158553720513 no 839 0.227599457985957 1143 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1413 3910-0535 34.4 µM 0.74588290634002 0.236411043255962 no 840 0.227869076007387 1121 2876951
SGTC_442 cape 100 µM 0.74443586306833 0.236820556536179 no 841 0.228306414642741 1072 5281787
SGTC_605 1315-0399 119 µM 0.741941220830459 0.237527455297861 no 842 0.229061474745619 1153 24020461
SGTC_386 1509-0011 3.07 µM 0.741522502825926 0.237646219478319 no 843 0.229188346410045 1175 3107280
SGTC_1956 st077085 54 µM 0.738779555173517 0.238425027884754 no 844 0.230020434205692 1156 24208685
SGTC_2955 9076254 12.21 µM 0.738338780066692 0.238550307889968 no 845 0.230154303167508 1085 16459619
SGTC_1991 st073000 8.92 µM 0.736838508905839 0.238976994767725 no 846 0.230610280940301 1151 4301969 YIL048W NEO1
SGTC_1425 4048-4433 7.33 µM 0.7368362875115 0.238977626855964 no 847 0.230610956463263 1190 23734946
SGTC_2670 beta-carotene 100 µM 0.735858033126579 0.239256073768627 no 848 0.230908549713421 1088 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2519 cryptotanshinone 88.04 µM 0.734803326459282 0.239556480261941 no 849 0.231229640468077 1124 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3307 9126885 69.2785 µM 0.734775120692323 0.239564516786608 no 850 0.231238230739426 1132 24824909
SGTC_2050 5263056 171 µM 0.734293449570382 0.239701779586438 no 851 0.231384954657982 1153 763468 YGL055W OLE1
SGTC_1658 st012944 20 µM 0.727641760285645 0.241601706747061 no 852 0.233416455068952 1096 24207260
SGTC_426 0988-0037 14.6 µM 0.726973662373108 0.241792986904553 no 853 0.233621045062106 1176 5383008
SGTC_857 0438-0306 1.35 µM 0.726857235980863 0.241826328836458 no 854 0.23365670820268 1141 4686136
SGTC_177 1327-0068 8.361 µM 0.725258434250012 0.242284442390486 no 855 0.23414675021943 1150 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2767 sibutramine 71.45 µM 0.724975843730144 0.242365463509431 no 856 0.234233424999674 1172 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_546 peri-Naphthalide 147 µM 0.724616832259841 0.24246841633732 no 857 0.23434356485135 1106 223824 A penicillin ester.
SGTC_1140 3229-1848 2.98 µM 0.723761812684432 0.242713703541641 no 858 0.234605988644692 1158 2849525
SGTC_3211 9128781 49.47 µM 0.723415330886458 0.242813140143264 no 859 0.234712377575736 1077 17194361
SGTC_307 1501-1223 22.3 µM 0.72329032986744 0.24284901952107 no 860 0.23475076629692 1151 2830329
SGTC_1171 0368-0077 21.4 µM 0.723119362511913 0.242898097384809 no 861 0.234803277234165 1127 3239779
SGTC_553 k007-0256 45.7 µM 0.722571849801085 0.243055302406737 no 862 0.234971484047356 1183 6287000
SGTC_3200 9114385 49.47 µM 0.722398176421344 0.243105180007084 no 863 0.235024853875828 1146 17018030 YLR208W SEC13
SGTC_179 1273-0063 6.77 µM 0.722254943246328 0.243146319589419 no 864 0.235068874468234 1136 3108139
SGTC_2775 cyproheptadine 69.59 µM 0.721188745887676 0.243452672175982 no 865 0.235396697511537 1187 2913 A selective serotonin reuptake inhibitor.
SGTC_3136 9095672 49.47 µM 0.720394574080518 0.243680998568558 no 866 0.235641044907159 1009 17217380
SGTC_3351 9150312 21.596 µM 0.720139763185923 0.243754281833669 no 867 0.235719473671221 1147 4904905
SGTC_3261 9137475 49.47 µM 0.718949729226448 0.244096691442966 no 868 0.236085947181261 1020 17027690
SGTC_1720 st037298 9.481 µM 0.716337164228479 0.244849316254625 no 869 0.23689159205823 1150 597396
SGTC_2304 7443016 91.4 µM 0.713571134506733 0.245647510193994 no 870 0.237746206011787 1096 939854
SGTC_2763 lisinopril 49.32 µM 0.711906102607939 0.246128661827647 no 871 0.23826146146402 1139 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2475 5812728 15.03 µM 0.711582221150334 0.246222313974583 no 872 0.238361759806169 1194 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1736 st036774 51 µM 0.710120288451085 0.246645277711858 no 873 0.238814773011283 1201 1272247
SGTC_2977 9011197 71.43 µM 0.710107079795017 0.246649100989471 no 874 0.238818868160363 1125 2704722
SGTC_3138 9097216 49.47 µM 0.708134820130706 0.24722033237905 no 875 0.239430769051915 1203 25237486
SGTC_1846 st056244 14.8 µM 0.707861855735361 0.247299447555385 no 876 0.239515524667842 1175 5393182
SGTC_959 1222-0044 107 µM 0.70453902659035 0.248263610641609 no 877 0.240548577441709 1173 6083612
SGTC_1105 epirubicin 18.1 µM 0.703728261538246 0.248499168728671 no 878 0.240801008372356 1151 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3118 9124250 49.47 µM 0.702881795442899 0.248745226344283 no 879 0.24106470851075 1086 1504786
SGTC_1201 1889-3372 45.9 µM 0.702422129782376 0.248878900013501 no 880 0.241207974214208 1121 5392199
SGTC_2025 5147754 141 µM 0.700407789010471 0.249465133637266 no 881 0.241836336676221 1202 315777 YLR208W SEC13
SGTC_663 1486-0733 13.9 µM 0.700358330270332 0.249479536839533 no 882 0.241851776220694 1176 722445 YPR165W RHO1
SGTC_3303 9125618 40.5795 µM 0.699415132767021 0.249754296084848 no 883 0.242146316696166 1209 22695467
SGTC_3313 9133968 57.047 µM 0.696817512887963 0.250511828619841 no 884 0.242958502386085 1181 1494643
SGTC_2268 7933382 153.85 µM 0.69587641009411 0.250786578456476 no 885 0.243253115870512 1242 935025 YOR257W CDC31
SGTC_2685 mycophenolic acid 18.85 µM 0.695680509348634 0.25084379066813 no 886 0.243314467133884 1170 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2196 6573537 42.6665 µM 0.694940750052592 0.251059897394433 no 887 0.243546216826201 1230 2903087
SGTC_194 1486-1323 56.904 µM 0.694869662661814 0.251080669421217 no 888 0.243568493159324 1183 5178754
SGTC_2504 purpurogallin 52.29 µM 0.691292979707435 0.252126963446523 no 889 0.244690721336365 1145 5281571 An antioxidant.
SGTC_1131 3454-3128 32.3 µM 0.69081430334099 0.252267165863292 no 890 0.244841122871574 1241 710982
SGTC_22 0964-0034 14.468 µM 0.690063895608865 0.252487040031265 no 891 0.245077003315026 1191 138402
SGTC_3231 9132313 49.47 µM 0.688370292613312 0.2529836472231 no 892 0.245609813263554 1200 4905967
SGTC_1377 2944-0135 198 µM 0.687782660848944 0.253156075732433 no 893 0.245794828344605 1260 1894137
SGTC_1726 st035556 14.5795 µM 0.686236869893003 0.253609951428504 no 894 0.246281875627885 1229 5919439
SGTC_2696 st077691 74.316 µM 0.681169326523587 0.255100877527728 no 895 0.2478821771957 1200 757133
SGTC_2591 skatole 100 µM 0.680244274972619 0.255373531673706 no 896 0.248174901153123 1233 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2786 7743617 45.45 µM 0.679914199747536 0.255470856489243 no 897 0.248279394997386 1148 583674
SGTC_2517 totarol 10 µM 0.679464368345415 0.255603523384074 no 898 0.248421838514705 1189 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_686 1319-0111 510 µM 0.679012575416515 0.255736804993622 no 899 0.248564946997605 1269 4562600
SGTC_1915 st067105 30.6 µM 0.678658971979178 0.255841145424477 no 900 0.248676983923433 1222 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2233 sulbentine 40.3845 µM 0.677650293320313 0.256138905884526 no 901 0.248996724857152 1213 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1729 st035615 45.989 µM 0.676976495726489 0.25633791058107 no 902 0.249210433691039 1191 17385451
SGTC_2933 9026794 32.47 µM 0.671881013028123 0.257845455545008 no 903 0.250829724379094 1233 17586027
SGTC_2594 a-mangostin 100 µM 0.671290455861363 0.25802047430043 no 904 0.251017756762694 1251 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_136 0097-0015 404.482 µM 0.669250326733795 0.258625564989494 no 905 0.251667903804339 1252 4861337
SGTC_2309 7664088 163.95 µM 0.669042568788418 0.258687226007081 no 906 0.251734161833966 1255 704922
SGTC_2174 5790901 200 µM 0.667435065741995 0.259164578105441 no 907 0.252247136879598 1241 786020
SGTC_3095 9117207 49.47 µM 0.667399953949464 0.259175009720396 no 908 0.252258347655436 1200 17015229
SGTC_2407 paclitaxel 400 µM 0.66539617451381 0.259770686399205 no 909 0.2528985655495 1322 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2638 epoxomicin 18 µM 0.664965670915014 0.25989875716841 no 910 0.253036225196946 1237 9915668 A protesome inhibitor.
SGTC_185 k048-0037 25.491 µM 0.664122959339581 0.260149550177996 no 911 0.253305808281873 1249 6827589
SGTC_505 gw-5074 63.9 µM 0.663806912647788 0.260243638594443 no 912 0.25340695040707 1264 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_630 4356-0227 183 µM 0.663565922129635 0.260315394257071 no 913 0.253484087111049 1260 779312
SGTC_1465 k213-0056 144 µM 0.662599458594153 0.260603264100793 no 914 0.2537935585131 1176 24048857 YMR208W ERG12
SGTC_3164 9100705 49.47 µM 0.662205366947181 0.260720694854288 no 915 0.253919807554306 1253 17174235
SGTC_412 gemfibrozil 100 µM 0.658479500173966 0.261832266380406 no 916 0.255115032720677 1236 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2813 7971799 71.43 µM 0.657848134936266 0.26202086784425 no 917 0.255317860282866 1286 2234054
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.657594873562235 0.262096541663785 no 918 0.255399244774231 1266 2724 A muscle relaxant with antifungal properties.
SGTC_2860 9025725 38.96 µM 0.655669982700701 0.262672059752475 no 919 0.256018243278273 1217 40546248
SGTC_166 k072-0058 166.424 µM 0.655335930284015 0.262772003011977 no 920 0.256125746123883 1266 5846229
SGTC_1316 1272-0050 65.9 µM 0.652296632712159 0.263682205969625 no 921 0.257104915941013 1266 7340392
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.650758161162684 0.264143556764876 no 922 0.257601306055027 1279 3256 An antibiotic and ribosome inhibitor.
SGTC_817 1391-0715 46 µM 0.648877075421397 0.26470820755767 no 923 0.2582089167206 1238 1353946
SGTC_2787 5284540 71.43 µM 0.648855656932816 0.264714640338135 no 924 0.25821583939513 1289 736958
SGTC_2997 9067075 71.4286 µM 0.648115195663774 0.264937077670858 no 925 0.25845522319187 1261 27209819
SGTC_2119 5528445 120.635 µM 0.644030879737556 0.266165726004584 no 926 0.259777705002926 1312 791935
SGTC_816 0325-0417 81.3 µM 0.643880318124179 0.266211073183959 no 927 0.259826522776111 1254 68101
SGTC_2346 9031566 143.75 µM 0.643033715907447 0.266466131451649 no 928 0.260101111362892 1266 4771086
SGTC_3131 9127911 49.47 µM 0.641773955723471 0.266845891689121 no 929 0.260509981149612 1321 45595681
SGTC_291 SEC14.278 35.5 µM 0.638979909701897 0.267689143849149 no 930 0.261418000762248 1272 1068044
SGTC_135 0933-0004 26.348 µM 0.638125283166833 0.267947340860135 no 931 0.261696064764739 1258 21230617 YGL099W LSG1
SGTC_2263 7948595 193.29 µM 0.637737058875386 0.26806467134065 no 932 0.261822428762959 1283 2971371
SGTC_2819 7996655 46.38 µM 0.637095437187049 0.268258641131188 no 933 0.262031340234165 1201 6456960
SGTC_517 1365-0151 113 µM 0.636419741914399 0.268462988075852 no 934 0.262251438373742 1322 768657
SGTC_3319 9138450 16.7555 µM 0.632664959569645 0.269599950962251 no 935 0.263476228419229 1277 2029690
SGTC_2628 lathosterol 100 µM 0.629594716346537 0.270531422183287 no 936 0.264479890687531 1338 6710616
SGTC_2199 6590217 200 µM 0.628982233641993 0.270717433521648 no 937 0.264680343760539 1278 703109
SGTC_2511 berberine 10.47 µM 0.627495597224533 0.271169191279185 no 938 0.265167210647388 1299 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3009 9080819 71.4286 µM 0.625962853364366 0.271635353341555 no 939 0.265669653258822 1283 17027216
SGTC_2378 9074213 121.43 µM 0.62566149419749 0.271727054323353 no 940 0.26576849735521 1277 657714
SGTC_1913 st060213 96.1 µM 0.620576122436606 0.273276808817397 no 941 0.267439277081018 1324 688959
SGTC_2207 7258803 200 µM 0.618090100956414 0.274036007797225 no 942 0.268257973603638 1266 3666799
SGTC_221 trifluoperazine 10.304 µM 0.616641770583992 0.274478789226838 no 943 0.268735518303613 1307 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2636 apigenin dimethyl ether 100 µM 0.616060247642364 0.27465667084454 no 944 0.268927378621934 1323 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1990 st072050 59.8 µM 0.615022490919504 0.274974250664846 no 945 0.269269933720158 1305 17233948
SGTC_1328 1441-0025 69.2 µM 0.614836347715961 0.275031234326626 no 946 0.269331401225057 1243 4562601
SGTC_1344 1488-0097 29.1 µM 0.614391659443443 0.275167389437668 no 947 0.269478272981442 1330 747966
SGTC_2126 5251174 33.877 µM 0.613014709862597 0.27558919564533 no 948 0.269933306690006 1382 790722
SGTC_2827 7993847 71.43 µM 0.61209776337339 0.275870263607499 no 949 0.270236538629562 1324 2985692
SGTC_1977 st070720 65.3 µM 0.611694516701405 0.275993913776464 no 950 0.270369945213009 1317 682188
SGTC_2439 5492030 7.2 µM 0.610072411493446 0.276491585304326 no 951 0.270906920563068 1296 5722370
SGTC_2815 7968870 71.43 µM 0.609341435189561 0.276715996913111 no 952 0.271149073919526 1318 2977326 YHR190W ERG9
SGTC_2946 9065502 71.43 µM 0.605429889635854 0.277918365730062 no 953 0.272446698012049 1193 16489101
SGTC_283 0987-0079 11.7 µM 0.604698701745648 0.278143407918015 no 954 0.272689605462921 1347 411556
SGTC_2705 st078069 42.8 µM 0.602979773286891 0.27867280288605 no 955 0.273261072533771 1310 1530061
SGTC_2483 5729050 27.16 µM 0.602889448723097 0.278700634574045 no 956 0.273291117821722 1407 2865180
SGTC_3202 9113761 49.47 µM 0.602604203546562 0.278788535991359 no 957 0.273386011650557 1428 4798415
SGTC_40 0327-0103 19.753 µM 0.601794605922554 0.279038095817375 no 958 0.273655433065378 1307 409036
SGTC_2619 obliquin 87.91 µM 0.60144648676304 0.279145437523182 no 959 0.273771322044495 1339 6708593 A bioactive alkalod. YER133W GLC7
SGTC_761 k216-0224 480 µM 0.599956584925848 0.279605071850444 no 960 0.27426758490934 1393 1340404
SGTC_1294 1000-1494 117 µM 0.599182739996538 0.279843947683579 no 961 0.274525515640379 1308 712797 YDL207W GLE1
SGTC_470 aa-861 153 µM 0.59851500538813 0.280050148171962 no 962 0.274748174822375 1293 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1703 st026983 48.3 µM 0.598238141104009 0.28013566713227 no 963 0.27484052259986 1369 1104023
SGTC_812 4251-0442 148 µM 0.597789477078909 0.280274279156201 no 964 0.274990206469951 1327 5723007
SGTC_1398 3558-0053 112 µM 0.597005374930371 0.280516602481144 no 965 0.275251896028814 1296 4532369
SGTC_211 3455-0679 143.504 µM 0.595876911738238 0.28086552695207 no 966 0.275628729132251 1358 748649
SGTC_2295 7971645 200 µM 0.594751036254829 0.281213860257203 no 967 0.276004950716021 1401 2978226 YKL099C UTP11
SGTC_2838 9002687 71.43 µM 0.594660145016001 0.281241990089461 no 968 0.276035333851813 1330 6457060
SGTC_696 1560-0013 611 µM 0.594112837499929 0.281411404422786 no 969 0.276218322595179 1385 1650269
SGTC_2684 capsaicin 100 µM 0.593242879617851 0.281680793711235 no 970 0.276509309872473 1334 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_700 3453-2283 142 µM 0.592480271011122 0.281917043675191 no 971 0.276764514060151 1419 565664
SGTC_2580 diallyl disulphide 81.36 µM 0.592442997866823 0.281928593039569 no 972 0.276776990338983 1372 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1124 fisetin 1.16336 µM 0.588139368760382 0.283263635101446 no 973 0.278219375014306 1364 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1340 1486-1359 257 µM 0.587807162804514 0.283366815669445 no 974 0.278330867847074 1363 4309068
SGTC_2713 st079149 53.4 µM 0.587723267835076 0.283392875639632 no 975 0.27835902758276 1375 3103253
SGTC_3277 9138724 49.47 µM 0.586228412605792 0.283857409268863 no 976 0.278861015340188 1319 15943418
SGTC_1115 galangin 695.678 nM 0.584334254194022 0.284446551354551 no 977 0.279497725254233 1397 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_443 clozapine 122 µM 0.584303387137814 0.284456156802902 no 978 0.279508106871771 1300 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1850 st056238 17 µM 0.584125407791932 0.284511544809376 no 979 0.279567970896987 1341 5393177
SGTC_1889 st059080 5.18 µM 0.583518367450069 0.284700497346236 no 980 0.279772198017084 1381 176925 Isolated from Daphnopsis sellowiana.
SGTC_736 0958-0254 92.6 µM 0.582932411881048 0.284882943654313 no 981 0.279969400196852 1407 6812352
SGTC_984 1492-0255 2.91 µM 0.581542244363822 0.285316016755982 no 982 0.280437527743937 1370 1585198
SGTC_1895 st058434 18.3 µM 0.580809370003556 0.285544452229931 no 983 0.28068446964113 1378 5393175
SGTC_1878 temozolomide 1 mM 0.579808797508906 0.285856469167432 no 984 0.281021782118269 1389 5394 DNA alkylating agent.
SGTC_2472 5377652 49.4 µM 0.579791474525699 0.285861872566358 no 985 0.281027623757787 1345 1610903
SGTC_2038 4100038 30.985 µM 0.579147430996711 0.286062797603274 no 986 0.281244849119394 1388 3596803
SGTC_108 0509-0257 621.132 µM 0.57876061817716 0.286183505512336 no 987 0.281375353720932 1341 536624
SGTC_1414 3917-0015 5.4 µM 0.578061550053062 0.286401716433403 no 988 0.281611282496017 1368 6618702
SGTC_1591 genipin 88.4 µM 0.57677188295145 0.286804487222132 no 989 0.282046782929489 1414 442424 A DNA cross-linking agent.
SGTC_2941 9056145 11.23 µM 0.576034084287103 0.287035026841583 no 990 0.282296071770124 1283 2119517
SGTC_2288 7946289 167.31 µM 0.575904928873818 0.287075393000737 no 991 0.282339721952632 1468 1246052
SGTC_439 amiodarone 34.4 µM 0.575050745830785 0.287342426537169 no 992 0.282628488793286 1388 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_753 1322-0200 289 µM 0.574181242551914 0.287614370101531 no 993 0.282922580539344 1376 5403907
SGTC_730 1436-0052 41.2 µM 0.573917551209292 0.287696865548159 no 994 0.283011797786283 1379 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2024 5144227 134 µM 0.572149757965137 0.288250205586858 no 995 0.283610260897499 1399 3475211
SGTC_670 4204-0025 119 µM 0.571682306381106 0.288396607290889 no 996 0.283768611767406 1435 719039
SGTC_1678 st019265 80.2 µM 0.570690587361284 0.288707320936494 no 997 0.284104700187927 1452 5367020
SGTC_1001 4048-4355 44.4 µM 0.56869547558839 0.289332882825763 no 998 0.284781409384846 1353 21824233
SGTC_519 k048-0011 62.8 µM 0.567218434830659 0.289796414879651 no 999 0.28528289239603 1413 6836379
SGTC_3142 9086498 49.47 µM 0.566542484729176 0.29000866094134 no 1000 0.285512530356762 1326 25236367
SGTC_1168 k815-0004 80.5 µM 0.565104528825028 0.290460416515137 no 1001 0.286001334146471 1357 642433
SGTC_2518 prenyletin 46.28 µM 0.564939532995779 0.290512273507192 no 1002 0.286057446540447 1345 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3014 9081533 49.47 µM 0.563356550138047 0.291010013589025 no 1003 0.286596058895902 1447 21367265
SGTC_1636 st007707 68.9 µM 0.562886361277161 0.291157932607316 no 1004 0.286756133986157 1451 403051
SGTC_3190 9110366 49.47 µM 0.562590091682897 0.291251155538207 no 1005 0.286857020286118 1368 17123768
SGTC_2807 7945238 51.95 µM 0.561907222021056 0.291466077453063 no 1006 0.287089616435889 1430 17148797
SGTC_1039 k821-0043 94 µM 0.56170613549273 0.291529380203824 no 1007 0.287158126687876 1413 15992768
SGTC_2361 9034121 116 µM 0.561500442219274 0.291594139807141 no 1008 0.287228214466298 1397 6496917
SGTC_1876 myriocin 605 nM 0.560461562852973 0.291921318647112 no 1009 0.287582325129484 1484 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2366 9070441 60.58 µM 0.559555639380677 0.292206764573736 no 1010 0.287891285019121 1344 6837235
SGTC_1741 st038134 10.228 µM 0.559528952764844 0.292215175183993 no 1011 0.287900388709216 1515 1272587
SGTC_1634 st006576 41 µM 0.557162545101088 0.292961424595186 no 1012 0.288708188827094 1467 3915356
SGTC_2246 7293507 91.5585 µM 0.554976115283388 0.293651702750102 no 1013 0.289455498796592 1464 887656
SGTC_1165 k072-0275 30.3 µM 0.554121923223089 0.293921584253086 no 1014 0.289747703677108 1402 6153523 YGL055W OLE1
SGTC_125 0133-0007 11.75 µM 0.552525899982934 0.294426154049154 no 1015 0.290294047263524 1481 26541
SGTC_305 1682-2595 20.8 µM 0.552413669147499 0.294461649959676 no 1016 0.290332483774555 1419 226033
SGTC_2244 6635614 200 µM 0.550806037116755 0.29497032190816 no 1017 0.290883322605635 1402 836499
SGTC_1266 0828-0227 32.9 µM 0.549969297439005 0.295235235381688 no 1018 0.291170216131872 1431 3913820
SGTC_1170 0310-0127 64.8 µM 0.549419390722806 0.295409396576261 no 1019 0.291358834956747 1453 774975
SGTC_296 1222-0039 74.9 µM 0.548429676472689 0.295722968425264 no 1020 0.291698451997375 1357 5984176
SGTC_184 1494-0393 24.714 µM 0.547755924886439 0.295936521067361 no 1021 0.291929753038651 1384 3090647
SGTC_2373 9071805 200 µM 0.546332168642209 0.296388028319244 no 1022 0.292418813788008 1476 10149009
SGTC_1924 st058459 75.1 µM 0.545163532688426 0.296758866618722 no 1023 0.29282052504517 1383 688683
SGTC_1947 st076332 61.6 µM 0.545134068239509 0.296768219192342 no 1024 0.292830656574473 1411 24208416
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.544728055186762 0.29689710915643 no 1025 0.292970283191658 1389 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3076 9116187 49.47 µM 0.543235740241079 0.29737106860262 no 1026 0.293483750876918 1477 27241210
SGTC_2642 cholecalciferol 100 µM 0.543085973905077 0.297418653490917 no 1027 0.293535304677164 1449 9821465 A vitamin D precursor, similar to steriods.
SGTC_1391 3442-0225 151 µM 0.54098503477431 0.298086545951594 no 1028 0.294258948867524 1427 5227075
SGTC_1600 coumarin 106 71.1 µM 0.540054377095533 0.298382622004058 no 1029 0.294579766289586 1458 100336 A hepatotoxic, DNA x-linker.
SGTC_1469 k284-2957 126 µM 0.538637743321749 0.298833561471076 no 1030 0.295068419509243 1463 23884841
SGTC_128 0906-2981 13.371 µM 0.537660883725622 0.299144693353033 no 1031 0.295405594490987 1473 6740226
SGTC_1769 st044406 64.4 µM 0.534782247084489 0.300062399166917 no 1032 0.296400220215124 1437 670903
SGTC_1771 st048882 4.1505 µM 0.533475146871796 0.300479521107146 no 1033 0.29685235533275 1371 4580403
SGTC_3153 9100258 49.47 µM 0.53277749566291 0.300702262770404 no 1034 0.297093806897322 1386 25236848
SGTC_358 0075-0058 9.45 µM 0.532443668309388 0.300808871408052 no 1035 0.297209373660734 1544 1069125
SGTC_2334 9017922 200 µM 0.530941793111052 0.301288709947545 no 1036 0.297729557641406 1560 3163164
SGTC_2727 riluzole 51.77 µM 0.530659154400055 0.301379049547532 no 1037 0.297827497767662 1440 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1012 4112-3522 18 µM 0.530251598752177 0.30150933771974 no 1038 0.297968750044785 1470 3112398
SGTC_1104 tacrolimus 29.8 µM 0.529287171071945 0.301817748710932 no 1039 0.298303126839912 1458 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3017 9080681 49.47 µM 0.522306406022293 0.304054317537754 no 1040 0.30072850482648 1420 16451914
SGTC_2201 6605497 169.863 µM 0.520727836924218 0.304561097993063 no 1041 0.301278189844007 1491 670741
SGTC_145 3737-0113 38.366 µM 0.520412190379383 0.304662477551408 no 1042 0.301388157683278 1441 6849351
SGTC_2989 9073649 71.4286 µM 0.519699825842446 0.30489133037989 no 1043 0.301636404156447 1456 21367202
SGTC_1806 st050005 60.3 µM 0.517198581772589 0.305695479322302 no 1044 0.302508770978325 1413 5194765
SGTC_884 0851-0618 334 µM 0.516898119197899 0.305792141094578 no 1045 0.30261364031561 1481 9642473
SGTC_803 4488-1585 147 µM 0.514829180165776 0.306458106284288 no 1046 0.303336196292296 1495 747204
SGTC_2689 tacrolimus 100 µM 0.514672666405163 0.306508512130085 no 1047 0.303390888494462 1470 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.513250864205834 0.306966576465889 no 1048 0.303887925040702 1491 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3287 9117173 37.0625 µM 0.512123927305595 0.30732985780528 no 1049 0.304282139773618 1449 2789709
SGTC_3116 9124943 49.47 µM 0.511536411598294 0.307519325414763 no 1050 0.304487749404746 1376 41905195 YPL160W CDC60
SGTC_1028 k015-0029 4.8 µM 0.510598465993835 0.30782190940614 no 1051 0.304816125122099 1459 4588309
SGTC_1815 st051655 58.2 µM 0.508964662078754 0.308349291452034 no 1052 0.305388497064018 1470 5984156
SGTC_3236 9132701 49.47 µM 0.506633372681032 0.309102502751709 no 1053 0.306206043873784 1432 24282524
SGTC_2438 5259590 200 µM 0.506173060275579 0.309251319152582 no 1054 0.306367582575435 1546 1201127
SGTC_1298 1079-1278 263 µM 0.50478265487751 0.309701019339883 no 1055 0.306855749844434 1485 2840950
SGTC_2387 9077560 195.08 µM 0.503975557329971 0.30996219047298 no 1056 0.307139276698761 1424 5303272
SGTC_1132 3456-3614 2.5 µM 0.503889749651225 0.309989962882455 no 1057 0.307169427029874 1681 3125502
SGTC_2195 6536160 144.242 µM 0.499215106454245 0.311504587137879 no 1058 0.308813926730515 1386 3834386
SGTC_1715 st032160 10.2275 µM 0.497218559898543 0.312152460684089 no 1059 0.309517467326336 1527 5289825
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.496688946347406 0.312324416387432 no 1060 0.309704209241991 1462 229346 A bile salt which induces apoptosis.
SGTC_280 3448-3607 3.04 µM 0.493474988100649 0.313368804811925 no 1061 0.310838504274167 1495 626179
SGTC_648 0375-0473 33.3 µM 0.491211550614654 0.314105217571511 no 1062 0.311638415141667 1518 1713139
SGTC_1925 st057770 10.1 µM 0.489564041393459 0.314641703198048 no 1063 0.312221213436855 1408 5989122
SGTC_141 0443-0274 32.331 µM 0.488929965513987 0.314848284507077 no 1064 0.312445640051419 1554 1627241
SGTC_2004 4023728 41.89 µM 0.488923814743279 0.314850288706118 no 1065 0.312447817413539 1539 360084 YDR527W RBA50
SGTC_1822 st052468 42 µM 0.488206385120076 0.315084097095934 no 1066 0.312701831158285 1461 2873678
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.485387942241853 0.316003336787938 no 1067 0.313700591963288 1529 7104
SGTC_1195 1502-0147 41.1 µM 0.485301337613603 0.316031601089186 no 1068 0.313731303396879 1470 817940
SGTC_1037 k284-1091 78.7 µM 0.484497791737482 0.316293897715519 no 1069 0.314016315581159 1481 3334711
SGTC_468 gf-109203x 121 µM 0.483039555504019 0.316770137038516 no 1070 0.314533825276167 1512 2396 A protein kinase C inhibitor.
SGTC_321 4534-3890 65.3 µM 0.481915975343583 0.317137289713144 no 1071 0.31493281851334 1555 699746
SGTC_1210 3013-0140 750 nM 0.480734690063076 0.317523492905043 no 1072 0.315352536375854 1632 905973
SGTC_1245 0418-0076 17.2 µM 0.480466506338132 0.317611199170516 no 1073 0.315447856912625 1541 6790114
SGTC_3247 9135149 49.47 µM 0.478704659632227 0.318187644334304 no 1074 0.316074375225377 1507 8934436 YOR116C RPO31
SGTC_662 k832-1615 104 µM 0.477229804925668 0.318670529680351 no 1075 0.316599244808796 1571 5878478
SGTC_3170 9103054 49.47 µM 0.476975785692565 0.318753729786446 no 1076 0.316689682209921 1454 16432970
SGTC_785 1270-0111 65.3 µM 0.476549906505792 0.318893240484346 no 1077 0.316841330773504 1478 6741994
SGTC_415 dibenzyl ketone 100 µM 0.476335851986805 0.31896337075659 no 1078 0.316917563686684 1618 7593
SGTC_2086 5274770 176.623 µM 0.474695076486089 0.319501149994162 no 1079 0.317502163876263 1515 689278
SGTC_2124 5246320 200 µM 0.474660456591407 0.319512501078155 no 1080 0.317514503684561 1546 579342
SGTC_1358 1509-0022 2.48 µM 0.474381304843972 0.319604034829683 no 1081 0.317614011079534 1514 3258434
SGTC_29 0299-0004 12.984 µM 0.473676348666232 0.31983523860433 no 1082 0.317865360837723 1462 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3269 9137823 49.47 µM 0.472074022967612 0.320361012079207 no 1083 0.318436976774994 1492 17682936
SGTC_367 0335-0881 7.1 µM 0.471778693927793 0.320457958237512 no 1084 0.318542380117063 1581 23828853
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.467131865789787 0.321984958279874 no 1085 0.320202768434981 1500 4330530
SGTC_2721 ifenprodil 61.44 µM 0.462824535595439 0.323403085516539 no 1086 0.321745071452174 1605 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1948 st076329 66.6 µM 0.462455918647638 0.323524567040909 no 1087 0.321877203461763 1459 24208413
SGTC_1693 xanthone 101.9 µM 0.458875341962623 0.324705560283496 no 1088 0.323161843440799 1571 7020 An insecticide.
SGTC_459 nigericin 15.3 µM 0.458676875567989 0.324771072816242 no 1089 0.323233111161211 1556 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_804 1595-0054 20.9 µM 0.457377440251994 0.325200142251589 no 1090 0.323699888358059 1519 761523 Stimulates phospholipase C.
SGTC_3080 9117754 49.47 µM 0.456488145007912 0.325493918412637 no 1091 0.324019496900058 1653 9550191
SGTC_1481 3346-2004 36 µM 0.454764597702001 0.326063596018949 no 1092 0.3246393010288 1537 2770522
SGTC_42 0133-0086 60.653 µM 0.454257299488055 0.326231348821377 no 1093 0.324821822968065 1448 162923 Model of phenazepam hydroxylation.
SGTC_3125 9127534 49.47 µM 0.453645501181925 0.326433704370042 no 1094 0.325041999178115 1507 1639235
SGTC_2507 purpurin 79.67 µM 0.453445690203118 0.326499803986426 no 1095 0.325113921126117 1464 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2970 9090938 41.86 µM 0.451400836031727 0.32717657655593 no 1096 0.325850340442487 1692 17217104
SGTC_3036 9090181 49.47 µM 0.451351669711968 0.327192855833467 no 1097 0.325868055235203 1562 25236586
SGTC_335 4077-0256 27.6 µM 0.450038741153916 0.327627696249325 no 1098 0.326341253179128 1621 3121989
SGTC_1969 st069479 40.1 µM 0.449923051904357 0.327666023616005 no 1099 0.326382962631391 1628 3895485
SGTC_2485 5633444 17.78 µM 0.448651043076512 0.328087554512723 no 1100 0.326841703122567 1500 5724239
SGTC_1907 st060210 83.7 µM 0.448491730478131 0.328140364546943 no 1101 0.326899176487453 1629 688793
SGTC_3195 9113082 49.47 µM 0.448061394836043 0.328283032331379 no 1102 0.327054444228683 1639 17018038
SGTC_2900 5328528 85.29 µM 0.446024095072849 0.328958791429027 no 1103 0.327789920505526 1500 795359
SGTC_1041 0206-0046 107 µM 0.445446772147074 0.329150387516308 no 1104 0.327998458904209 1579 50494
SGTC_864 0469-0573 172 µM 0.444619471727876 0.329425021839879 no 1105 0.32829738671149 1525 689425
SGTC_1471 k673-0312 37 µM 0.443167291456997 0.329907316567586 no 1106 0.328822367710884 1571 24099884
SGTC_473 2-arachidonoylglycerol 10 µM 0.439392678626209 0.331162253882229 no 1107 0.330188515289276 1540 5282280 An endocannabinoid.
SGTC_1144 3486-0183 12.5 µM 0.438394340564228 0.33149448726704 no 1108 0.33055022414971 1577 6744069
SGTC_3149 9097855 49.47 µM 0.435057381706944 0.332605943306345 no 1109 0.33176038855542 1713 25236625 YMR079W SEC14
SGTC_904 1141-0088 396 µM 0.434978195472181 0.332632336155691 no 1110 0.331789127228466 1486 1378119
SGTC_1996 st072960 66.8 µM 0.433256260755367 0.333206463646072 no 1111 0.332414305132491 1630 1719405
SGTC_746 1095-0025 46.6 µM 0.429375403555764 0.334501851393818 no 1112 0.333825025311754 1673 6749286
SGTC_523 1934-0222 13.7 µM 0.429314454398094 0.334522211330825 no 1113 0.333847199589754 1559 1361595
SGTC_2258 7960471 200 µM 0.429261654317643 0.33453984947926 no 1114 0.333866409572225 1547 2974708
SGTC_2440 5628896 157.78 µM 0.427308832593261 0.335192456231037 no 1115 0.334577200161036 1604 5522048
SGTC_315 k915-0449 187 µM 0.427047898370518 0.335279694679929 no 1116 0.334672220326957 1650 20970215 YNL149C PGA2
SGTC_3258 9138477 49.47 µM 0.425141157819862 0.335917446911687 no 1117 0.335366888035952 1617 4970355
SGTC_1236 0330-0013 258 µM 0.424437463876925 0.33615293269377 no 1118 0.335623401714808 1584 4617066
SGTC_3117 9124945 49.47 µM 0.423040706827354 0.336620537175992 no 1119 0.336132780761977 1497 17592065
SGTC_3011 9081274 71.4286 µM 0.422749931903712 0.336717914228789 no 1120 0.336238860467236 1586 6625322
SGTC_951 1171-0579 82.7 µM 0.422498317562754 0.336802185705845 no 1121 0.336330664241564 1513 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1067 clotrimazole 1.36 µM 0.421582201315104 0.337109083483856 no 1122 0.336664999986454 1589 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1428 4049-0204 61.7 µM 0.420616863946905 0.337432587618039 no 1123 0.33701743867406 1682 X1428
SGTC_3333 9141820 12.094 µM 0.419965933057096 0.337650795633006 no 1124 0.337255170319881 1578 1939433
SGTC_637 1181-0519 7.26 µM 0.419316690659738 0.337868492004313 no 1125 0.337492350042635 1580 6252091 YGR060W ERG25
SGTC_1362 1611-0397 101 µM 0.410662569687141 0.340775446289439 no 1126 0.340659988384191 1602 27816
SGTC_1604 st002052 72.4 µM 0.410216127399451 0.340925666681718 no 1127 0.340823705718182 1630 6254834 YHR062C RPP1
SGTC_2621 lithochol-11-enic acid 100 µM 0.408872562879756 0.341377905863533 no 1128 0.341316592536074 1758 6708711
SGTC_1259 0671-0132 43 µM 0.408498764528308 0.341503765644476 no 1129 0.341453768699035 1599 X1259
SGTC_472 calcifediol 10 µM 0.407051415514052 0.34199126147309 no 1130 0.341985112902171 1643 5283731 A vitamin D metabolite.
SGTC_2533 agelasine 13.65 µM 0.405993109648075 0.342347886713918 no 1131 0.342373831592837 1778 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3052 9092717 49.47 µM 0.403085435376793 0.343328430594501 no 1132 0.343442687363224 1607 25237534
SGTC_782 0083-0095 30.5 µM 0.402921297067886 0.343383813864419 no 1133 0.343503061754447 1614 3591729 An indicator and reagent.
SGTC_400 oxethazaine 37.5 µM 0.400497739439893 0.344201957452108 no 1134 0.344394974070053 1608 4621 A local anesthetic.
SGTC_844 0330-0132 15.3 µM 0.399263450624984 0.344618908875507 no 1135 0.344849547468424 1693 2828079
SGTC_3084 9116877 49.47 µM 0.397525227941331 0.345206412841186 no 1136 0.345490093354694 1717 27241325
SGTC_1887 st057648 70.8 µM 0.397001189499403 0.345383606511687 no 1137 0.345683291722348 1744 688672
SGTC_2537 larixol 68.93 µM 0.396823440727192 0.345443716590903 no 1138 0.345748831872483 1672 6708759
SGTC_1935 st074532 41.6 µM 0.394060562044638 0.346378551710493 no 1139 0.34676816350201 1782 2829742
SGTC_2917 7979103 53.79 µM 0.393434098090167 0.346590649679247 no 1140 0.346999444684599 1725 2980565
SGTC_3346 9158254 43.5805 µM 0.393233295455944 0.346658644349535 no 1141 0.347073590102616 1631 17639500
SGTC_1758 st042942 75.2445 µM 0.392803860537877 0.346804073787898 no 1142 0.347232176550854 1663 669317
SGTC_942 3253-1115 227 µM 0.392446754102652 0.346925026158393 no 1143 0.347364073116464 1733 46497897
SGTC_3336 9143619 71.43 µM 0.391728171354789 0.347168458248251 no 1144 0.347629536263666 1697 45595730
SGTC_573 3702-0553 84.7 µM 0.391279591707527 0.347320454193002 no 1145 0.347795291143021 1631 1222756
SGTC_3143 9086658 49.47 µM 0.390772591045924 0.347492274975343 no 1146 0.347982668224348 1624 25236626
SGTC_1638 st008370 60.6 µM 0.390751366528741 0.347499468574973 no 1147 0.347990513182009 1586 24207134
SGTC_1628 st004252 77.7 µM 0.388964314243787 0.348105348776319 no 1148 0.348651272436442 1760 692968
SGTC_2783 7738165 71.43 µM 0.386017521055658 0.349105272920953 no 1149 0.349741846343465 1541 17201110
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.385958668801652 0.349125253735092 no 1150 0.349763639547851 1758 94937 An inhibitor of serotonin biosynthesis.
SGTC_2571 chrysanthemic acid 100 µM 0.385943794789252 0.349130303648288 no 1151 0.34976914752728 1569 2743 An insecticide.
SGTC_3213 9129884 49.47 µM 0.384805521918102 0.349516840711693 no 1152 0.350190753841723 1518 17190742
SGTC_2214 7179297 48.276 µM 0.383002936586337 0.350129285569154 no 1153 0.350858793360455 1703 769744
SGTC_3140 9094243 49.47 µM 0.38181508339174 0.350533082847686 no 1154 0.351299264977523 1676 19291112
SGTC_2680 butyl paraben 22.24 µM 0.381704000104317 0.350570853002316 no 1155 0.351340466349228 1664 7184 An antifungal and steroid mimetic.
SGTC_313 3474-0040 5.03 µM 0.38119682646551 0.350743319191375 no 1156 0.351528601892245 1622 1043375 YIL048W NEO1
SGTC_2950 9072895 21.46 µM 0.379750203122604 0.351235417481633 no 1157 0.352065425055403 1594 17332245
SGTC_2121 5257820 149.641 µM 0.379731037606787 0.351241938697387 no 1158 0.352072539111866 1792 791256
SGTC_3275 9138069 49.47 µM 0.378685588702637 0.351597727124745 no 1159 0.352460678142156 1717 17617007
SGTC_2351 9026858 72.31 µM 0.377834039459541 0.351887623501443 no 1160 0.352776942527689 1584 1409300
SGTC_2963 9082507 9 µM 0.376937133086543 0.352193054119087 no 1161 0.353110162542307 1708 16459611
SGTC_1602 st001878 87.6 µM 0.376688363041738 0.352277786651295 no 1162 0.353202605935892 1725 595405 YLR310C CDC25
SGTC_261 5-fluorouridine 15.376 µM 0.373490081287584 0.353367791966358 no 1163 0.354391863066297 1732 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.372433000841326 0.353728320327078 no 1164 0.354785243576277 1619 2333 A French combination drug.
SGTC_2937 9044753 11.33 µM 0.371227222615884 0.354139723833368 no 1165 0.355234149376335 1629 6465530 YGL099W LSG1
SGTC_207 4185-0010 4.486 µM 0.37040199907401 0.354421382812985 no 1166 0.355541492261462 1697 3761753
SGTC_448 monastrol 171 µM 0.36982102185055 0.354619725288209 no 1167 0.355757925415696 1698 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3188 9110789 49.47 µM 0.36942838588456 0.354753791407039 no 1168 0.355904221587042 1750 849217
SGTC_1567 st069303 68.4 µM 0.368113357923885 0.355202940558792 no 1169 0.356394355494263 1670 5581319
SGTC_2664 lyso-paf C-16 73.48 µM 0.366754466876394 0.355667282620422 no 1170 0.356901087259075 1686 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_895 0964-0006 13.7 µM 0.366112121737148 0.355886850827073 no 1171 0.357140706347662 1756 6738897
SGTC_1856 st057054 55.7 µM 0.365986077658387 0.355929941179238 no 1172 0.357187732184553 1784 1266018
SGTC_2854 9024559 71.43 µM 0.364862116025107 0.356314268261726 no 1173 0.357607167337291 1617 3163529
SGTC_1152 3909-8331 15.9 µM 0.36429209852205 0.356509235684622 no 1174 0.357819949788716 1672 16001939
SGTC_1618 st003135 44.5 µM 0.363968671719169 0.356619876494794 no 1175 0.357940701783996 1758 1270615
SGTC_429 1112-0049 25.5 µM 0.363622521917418 0.356738303964201 no 1176 0.358069953201274 1620 2836170
SGTC_2443 5493264 126.67 µM 0.36323154000721 0.356872086353197 no 1177 0.358215964375024 1780 5340055
SGTC_910 3454-3003 490 µM 0.362770527085168 0.357029853889104 no 1178 0.358388155087667 1761 820824
SGTC_1719 st032227 49.2 µM 0.362488980973386 0.357126216440418 no 1179 0.358493328184728 1617 3125804
SGTC_1417 3966-0327 90.4 µM 0.362008174757944 0.35729079923415 no 1180 0.358672960802494 1695 651118
SGTC_3126 9127922 49.47 µM 0.361791723940273 0.357364900290414 no 1181 0.358753838574704 1717 45595682
SGTC_2320 7373003 200 µM 0.361547590358278 0.357448484882827 no 1182 0.358845067730512 1605 5415828
SGTC_3292 9120825 59.784 µM 0.361122912497626 0.357593899140626 no 1183 0.359003782832702 1834 24824900
SGTC_3270 9137563 49.47 µM 0.359297280735652 0.358219250292861 no 1184 0.359686354184359 1758 17015724
SGTC_1884 5633444 25 µM 0.355837187302998 0.359405512166619 no 1185 0.36098124898998 1732 5724239
SGTC_2081 5214970 32.255 µM 0.35300335125651 0.360378078333775 no 1186 0.36204296406708 1789 2063512
SGTC_855 0428-0020 25 µM 0.352053316535987 0.360704330789762 no 1187 0.362399138949366 1702 6812414
SGTC_2399 5884133 200 µM 0.350086444507629 0.361380098523626 no 1188 0.363136911848092 1636 722445
SGTC_3013 9080133 71.4286 µM 0.348057587582834 0.362077616115376 no 1189 0.363898467690829 1760 17050193
SGTC_3055 9094636 49.47 µM 0.346871144996478 0.362485725601434 no 1190 0.364344062641904 1772 25236176
SGTC_865 0488-0499 301 µM 0.34512136041737 0.363087897176756 no 1191 0.365001567802436 1773 9634651
SGTC_1950 st077106 7.18 µM 0.345080372557461 0.363102006820031 no 1192 0.365016974311488 1664 13831864
SGTC_2889 9059656 51.95 µM 0.344851776939024 0.36318070188471 no 1193 0.365102902785507 1769 3949838
SGTC_2752 diclazuril 33.15 µM 0.342804781748887 0.363885646227999 no 1194 0.365872664192629 1810 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2514 salinomycin 42.74 µM 0.342688677034647 0.363925644213026 no 1195 0.365916340959008 1869 23682228 A polyether potassium ionophore.
SGTC_2429 5902844 64.44 µM 0.342228496732906 0.364084190554141 no 1196 0.36608947063573 1844 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2960 9079389 5.97 µM 0.337031522128351 0.365876318130171 no 1197 0.368046568802559 1847 16457355
SGTC_1478 0453-0656 35.7 µM 0.33542678214802 0.366430291576288 no 1198 0.368651583872472 1744 5258496
SGTC_349 k015-0014 24 µM 0.333675512989428 0.367035166179229 no 1199 0.369312214685375 1685 2196908
SGTC_491 tetrandrine 80.3 µM 0.333304425149792 0.367163379451719 no 1200 0.369452249697936 1824 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_977 1348-1378 135 µM 0.333266283187418 0.367176558588702 no 1201 0.369466644064998 1718 X977
SGTC_1505 k297-0037 20.6 µM 0.332408743905039 0.367472904179668 no 1202 0.36979031844896 1687 4089396
SGTC_2952 9073731 13.78 µM 0.33188450556743 0.36765410762408 no 1203 0.369988235337975 1673 16457353
SGTC_2000 st075254 36.4 µM 0.329837521480346 0.368361931293062 no 1204 0.370761367199407 1707 17234175
SGTC_3349 9149703 23.001 µM 0.329536973780021 0.368465894938022 no 1205 0.370874926037593 1702 4910494
SGTC_3105 9121040 49.47 µM 0.328632114272634 0.368778956586319 no 1206 0.371216885708577 1822 41448907
SGTC_1965 Pectolinarigenin 58.4 µM 0.327293559805955 0.369242226895038 no 1207 0.371722931490543 1715 5320438 An anti-inflammatory.
SGTC_1003 4049-0218 100 µM 0.322772127373967 0.370808484237765 no 1208 0.373433911623783 1812 295161
SGTC_2148 5546263 113.568 µM 0.320157791558316 0.371715088950486 no 1209 0.374424358969479 1754 792097
SGTC_2079 5212404 121 µM 0.317144383598379 0.372760967777526 no 1210 0.375567024273944 1881 758462
SGTC_2880 9042983 58.44 µM 0.314733509548232 0.373598398471731 no 1211 0.376481999671458 1746 6464714
SGTC_742 0kpi-0133 140 µM 0.31245416157526 0.374390692185328 no 1212 0.37734769707507 1881 2728852
SGTC_2175 5807670 165.306 µM 0.311417084588056 0.374751352542571 no 1213 0.377741783782874 1860 241186
SGTC_1970 st070122 35.8 µM 0.310190511190788 0.375178054778494 no 1214 0.378208042941784 1831 102928
SGTC_2600 tangeritin 87.95 µM 0.309131926414678 0.375546439739012 no 1215 0.378610587006142 1687 68077 A bioactive flavone.
SGTC_2592 piperlongumine 83.33 µM 0.308454294603901 0.375782313585073 no 1216 0.378868336702648 1695 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2699 st077704 54.6 µM 0.308078746583801 0.375913056427228 no 1217 0.379011206496609 1774 645852
SGTC_2750 bromebric acid 70.15 µM 0.307705939313942 0.37604285919837 no 1218 0.379153049976793 1778 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1215 3852-0577 11.2 µM 0.307109500530283 0.37625055439431 no 1219 0.379380013272304 1872 2884876
SGTC_2843 9000894 45.46 µM 0.306995121473601 0.376290388196464 no 1220 0.379423542773502 1743 2242070
SGTC_1023 4482-3888 16 µM 0.304890708917159 0.377023508451378 no 1221 0.380224696143952 1866 3303168
SGTC_1448 4255-0083 152 µM 0.304129655959383 0.377288748009806 no 1222 0.380514557047348 1891 5399660
SGTC_1751 st044839 27.194 µM 0.304127058909562 0.37728965322387 no 1223 0.380515546296115 1838 5291326
SGTC_818 4072-2707 53.5 µM 0.304039395652658 0.377320209064338 no 1224 0.380548938785636 1708 882871
SGTC_556 4058-0063 51.5 µM 0.303753482255117 0.377419872164805 no 1225 0.38065785445422 1779 6615692
SGTC_2954 9074818 52.69 µM 0.302868857641102 0.377728284460207 no 1226 0.380994902670236 1819 16648742
SGTC_95 0471-0001 561.058 µM 0.301961675506143 0.378044642101772 no 1227 0.381340639258384 1688 4015405
SGTC_729 4092-0585 94.1 µM 0.301765759898082 0.378112973638101 no 1228 0.381415317189032 1715 2169061
SGTC_2420 aureobasidin a 50 nM 0.298754292197103 0.379163793290562 no 1229 0.382563764251798 1913 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_253 dyclonine 31.25 µM 0.298584966549698 0.379222904280005 no 1230 0.382628368712563 1845 3180 An oral anasthetic.
SGTC_73 0327-0325 16.231 µM 0.298362652591022 0.379300517590628 no 1231 0.382713195278261 1926 53298
SGTC_2140 5586273 200 µM 0.297545507994709 0.379585837444714 no 1232 0.383025034951569 1783 854421
SGTC_3246 9135460 32.98 µM 0.291517465425626 0.38169264728203 no 1233 0.385327794087742 1871 41446951
SGTC_2072 5231554 129 µM 0.291197329107377 0.381804634086027 no 1234 0.385450202585773 1953 789545
SGTC_1401 3807-4679 7.6 µM 0.290046855034602 0.382207162719346 no 1235 0.385890196189451 1781 3291456
SGTC_991 3996-0057 64.7 µM 0.289732052531603 0.382317328236156 no 1236 0.386010616592962 1796 715343
SGTC_256 clotrimazole 625 nM 0.287890436865502 0.382961994476238 no 1237 0.386715303721116 1799 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_114 0364-0001 490.298 µM 0.287878045432788 0.382966333256079 no 1238 0.38672004652322 1732 4003655
SGTC_79 0052-0007 94.094 µM 0.285926246957073 0.383649925820936 no 1239 0.387467305207037 1905 2801472
SGTC_3050 9093513 49.47 µM 0.284638324626034 0.384101202762338 no 1240 0.387960623216086 1787 25236664
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.284051841983392 0.384306753371861 no 1241 0.388185325976335 1934 1273210
SGTC_1865 st057639 52.2 µM 0.283830065381448 0.384384490182591 no 1242 0.388270306390638 1841 688818
SGTC_1973 st070275 50.2 µM 0.279876521466645 0.385771058182809 no 1243 0.389786120405268 1919 17118334
SGTC_182 3448-4371 550.524 µM 0.279011274083183 0.386074709055494 no 1244 0.390118086370906 2007 3491403
SGTC_2031 5180455 200 µM 0.278982029912366 0.386084973257638 no 1245 0.39012930776526 1800 29949
SGTC_2193 5925765 200 µM 0.2788780315496 0.38612147554434 no 1246 0.390169214122548 1895 877370
SGTC_2187 6125751 200 µM 0.278479956873969 0.386261204708681 no 1247 0.390321974431481 1841 874498
SGTC_1408 3909-7976 48.8 µM 0.278247716692545 0.386342730717243 no 1248 0.390411103930097 1845 24152374
SGTC_2555 cholic acid 100 µM 0.276390673206532 0.386994810781616 no 1249 0.391124009766285 1840 6708657 Influences liver metabolism.
SGTC_2412 st077135 33.4 µM 0.272746704304064 0.388275275536638 no 1250 0.392523965221307 1884 13258915
SGTC_1746 st038117 42 µM 0.272310646159243 0.388428584958315 no 1251 0.392691585489753 1807 2898218
SGTC_236 1509-0011 5.31 µM 0.271220337403582 0.388811991982823 no 1252 0.393110786011171 1903 3107280
SGTC_1753 st043925 64 µM 0.270851447014885 0.388941736814858 no 1253 0.393252644610827 1951 670181
SGTC_2382 9035899 200 µM 0.270654658712817 0.389010955572695 no 1254 0.393328326311745 1802 6462679
SGTC_2915 7971052 15.16 µM 0.270002949978987 0.389240214202586 no 1255 0.393578992055644 1910 5741558
SGTC_3288 9119690 36.221 µM 0.269373603708355 0.389461642748255 no 1256 0.393821098427604 1767 17595618 YKL019W RAM2
SGTC_78 0336-0123 156.75 µM 0.269262756886152 0.389500646700014 no 1257 0.393863744901421 1753 6765896
SGTC_342 k048-0088 23.3 µM 0.266731760688673 0.390391536872367 no 1258 0.394837849035589 1777 6820570
SGTC_3146 9095609 49.47 µM 0.265192302479167 0.390933695656608 no 1259 0.395430662208598 1883 17173999
SGTC_1759 st043059 70 µM 0.264346898454396 0.391231516135555 no 1260 0.395756312675045 1760 669426
SGTC_1024 4507-0395 26 µM 0.263880675196528 0.391395785417978 no 1261 0.395935933486474 1847 4201836
SGTC_1790 st045711 43.5 µM 0.263275590622878 0.391609010031318 no 1262 0.396169086040107 1961 585119
SGTC_2107 5363541 170.161 µM 0.262867866782081 0.391752705438238 no 1263 0.396326212063097 1890 244052
SGTC_17 0960-0276 49.807 µM 0.261179577079566 0.392347871721565 no 1264 0.396977013397601 1871 6821114
SGTC_1493 4348-0038 111 µM 0.260525603344634 0.3925784823318 no 1265 0.397229184189423 1884 800424
SGTC_2866 9034245 58.44 µM 0.258829739439988 0.39317666998581 no 1266 0.397883305403406 1981 6462273
SGTC_871 0574-0004 149 µM 0.257769898490883 0.393550639373697 no 1267 0.398292248554994 1848 9551173
SGTC_2641 levomentholum 100 µM 0.256867363178747 0.393869180246125 no 1268 0.398640582911365 1907 16666
SGTC_411 enrofloxacin 100 µM 0.256367170521399 0.394045748877459 no 1269 0.398833667540387 2014 71188 A bacterial gyrase inhibitor.
SGTC_575 k072-0246 11.9 µM 0.256139682756204 0.394126059549647 no 1270 0.398921490679824 1855 6796779
SGTC_2756 carbadox 75.1 µM 0.254647645314211 0.39465290934409 no 1271 0.399497628148946 1832 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_479 n-linoleoylglycine 10 µM 0.254464854699672 0.394717467375044 no 1272 0.399568226256447 1854 6433346 An anti-infammatory.
SGTC_2166 5933061 31.504 µM 0.253728837387369 0.394977443378759 no 1273 0.399852526956975 1948 2877375
SGTC_652 0437-0092 114 µM 0.253397667360775 0.395094434503011 no 1274 0.399980465014352 1824 3091274
SGTC_1732 st034308 51.822 µM 0.251003818653995 0.395940380610189 no 1275 0.400905578412981 1792 830119
SGTC_832 4083-0019 164 µM 0.250334358335012 0.396177044602531 no 1276 0.401164394015067 1948 1990758
SGTC_2695 st077686 51.995 µM 0.247720291396395 0.3971015211031 no 1277 0.402175415426287 1825 2876092
SGTC_213 1246-0773 967 nM 0.245456879809012 0.397902454278321 no 1278 0.403051345976328 1919 6251622
SGTC_2710 st078562 53.7235 µM 0.245406521712368 0.397920278954421 no 1279 0.403070839894344 1887 17250908
SGTC_3092 9117248 49.47 µM 0.2448989727028 0.398099942127958 no 1280 0.403267328569883 1950 17141857
SGTC_1885 st057546 99.9 µM 0.244236115469884 0.398334614136853 no 1281 0.403523978865235 1954 702008
SGTC_1312 1218-2183 165 µM 0.243743991099765 0.398508865210267 no 1282 0.403714550346438 1968 6744073
SGTC_2681 menadione 3.18 µM 0.243640341206588 0.398545568077371 no 1283 0.403754690908215 1903 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2270 7924575 90.91 µM 0.2411520186919 0.399426962297737 no 1284 0.404718648540261 2014 1262135
SGTC_601 0986-0029 62.9 µM 0.240662041881084 0.399600578644618 no 1285 0.404908530273909 1872 24747981
SGTC_1512 0259-0544 12.2 µM 0.239968079211834 0.399846508458667 no 1286 0.405177501377458 1909 18476
SGTC_2674 ligustilide 100 µM 0.239253733438454 0.400099703235366 no 1287 0.40545441949975 1904 5319022 A signalling regulator.
SGTC_711 k292-0785 179 µM 0.236203159285843 0.401181428944067 no 1288 0.406637514058966 1890 4146315
SGTC_1666 st014829 29 µM 0.23550214551177 0.401430114013118 no 1289 0.406909506900118 1861 3858230
SGTC_2826 7992541 19.48 µM 0.234750325871072 0.401696866869899 no 1290 0.407201262284621 1968 2985066
SGTC_2445 5742597 35.57 µM 0.234632380425327 0.40173871921131 no 1291 0.40724703753883 1854 1774255
SGTC_2298 7976326 193.81 µM 0.234028512103089 0.40195301645986 no 1292 0.407481421876825 1962 2235818
SGTC_597 k018-0003 82.8 µM 0.233269617840138 0.402222370202267 no 1293 0.407776024661983 1973 6786234
SGTC_2364 9055074 200 µM 0.232741658825344 0.402409785677503 no 1294 0.407981009148195 1849 6470630
SGTC_3166 9102297 49.47 µM 0.232675549591053 0.402433254787931 no 1295 0.408006678384869 1844 25237072
SGTC_968 1309-0633 340 µM 0.232109733343589 0.402634136776545 no 1296 0.40822639259536 2017 3761976
SGTC_2463 5473429 200 µM 0.231512618743982 0.402846158514409 no 1297 0.408458291679801 1884 5399405
SGTC_3025 9087895 49.47 µM 0.231469125326644 0.402861603149331 no 1298 0.408475184303446 2010 17173641
SGTC_531 3788-1495 174 µM 0.230188442364321 0.403316445117643 no 1299 0.40897267119982 1849 2896655
SGTC_1802 st050112 57.9 µM 0.230134684595399 0.403335540365731 no 1300 0.408993556853336 1996 4662563
SGTC_937 3122-0005 46.7 µM 0.229886345354099 0.40342375571215 no 1301 0.409090043513849 2011 759535
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.229763355914791 0.403467445979802 no 1302 0.409137830350974 1887 390807
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.228940625171527 0.403759740459565 no 1303 0.409457532332623 2000 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1531 st059297 52.4 µM 0.228620563491696 0.403873464444306 no 1304 0.409581920232695 1920 7566702
SGTC_613 3914-0030 117 µM 0.22846953400235 0.403927130908657 no 1305 0.409640619083996 1937 1145395
SGTC_584 0986-0246 15.4 µM 0.227867815486126 0.404140962100205 no 1306 0.409874502024367 2015 53315 YDR232W HEM1
SGTC_1649 st011737 51.3 µM 0.22684794533826 0.404503456170198 no 1307 0.410270990198491 1893 1761035
SGTC_1343 1487-0095 224 µM 0.226704764178581 0.404554353847976 no 1308 0.410326661144089 2022 4560101 YGL055W OLE1
SGTC_1440 4100-1550 40 µM 0.226636122937453 0.404578754836195 no 1309 0.410353350511408 1982 742806
SGTC_1350 1495-0454 146 µM 0.226455349394181 0.404643019043814 no 1310 0.410423641604062 1989 1069057
SGTC_3130 9127414 49.47 µM 0.225386991491248 0.405022868095925 no 1311 0.410839115303008 2038 1494646
SGTC_2262 9014885 67.46 µM 0.224360208510357 0.40538801975247 no 1312 0.411238515227153 2021 6457424
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.224069127672968 0.405491550928605 no 1313 0.411351757142602 2054 6708630 An antioxidant.
SGTC_2274 7947094 46.08 µM 0.223833499091169 0.4055753637766 no 1314 0.41144343135554 2049 2971028
SGTC_681 1642-0006 26.6 µM 0.223678642574766 0.405630448440543 no 1315 0.411503682831167 1987 4446530
SGTC_1986 st071812 45 µM 0.223448189068274 0.405712427488136 no 1316 0.411593351399523 1929 11838594
SGTC_1046 2001-0062 216 µM 0.223445304333527 0.405713453698811 no 1317 0.411594473867932 1856 739778
SGTC_870 0573-2213 57.6 µM 0.223045531205194 0.405855674581603 no 1318 0.411750035096851 1992 3916321
SGTC_1301 naphtanilide LB 4.81 µM 0.222451209061504 0.40606713001535 no 1319 0.411981325606152 2008 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_702 1488-0190 94 µM 0.221562027444838 0.406383545428244 no 1320 0.41232742274164 2046 949357
SGTC_2236 dapsone 200 µM 0.220595070312327 0.406727706664672 no 1321 0.412703869916445 2039 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1174 0739-0097 51.1 µM 0.220358815353977 0.406811805945176 no 1322 0.412795858821937 1910 728447
SGTC_708 3448-5400 146 µM 0.22017391886408 0.406877626235941 no 1323 0.412867853988351 2021 3462195
SGTC_1743 st037606 46.3785 µM 0.220016629388807 0.406933620927159 no 1324 0.412929101817123 1910 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1461 k072-0203 53.8 µM 0.217322661600461 0.407892961675533 no 1325 0.413978448845549 2018 5418714
SGTC_2395 5646831 180.19 µM 0.215661252301784 0.408484876944414 no 1326 0.414625903312469 1963 6808628
SGTC_326 k292-0812 17.5 µM 0.215487108157734 0.408546931915862 no 1327 0.414693781091607 2024 3579357
SGTC_3194 9111903 49.47 µM 0.215459850579497 0.40855664515887 no 1328 0.414704405761437 1972 17087251
SGTC_1020 4335-0961 93.3 µM 0.213788683551958 0.409152272913923 no 1329 0.415355925079645 1836 669075
SGTC_1867 st057372 64 µM 0.21378785884035 0.409152566904808 no 1330 0.415356246658413 2007 688837
SGTC_2040 5100729 123 µM 0.213554833256831 0.409235637258702 no 1331 0.415447112303746 1961 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1979 st071809 45.3 µM 0.213468673894605 0.409266352895893 no 1332 0.415480710301101 2002 4976333
SGTC_3175 9106517 49.47 µM 0.210177200644458 0.410440171846913 no 1333 0.416764686692334 1916 41468073
SGTC_1112 tnp00069 1.16933 µM 0.207189768364089 0.41150625772089 no 1334 0.417930828806295 2024 145826
SGTC_1456 k015-0012 13 µM 0.206571477764821 0.411726980902922 no 1335 0.418172268621042 2099 2989616
SGTC_722 3534-0461 190 µM 0.206000646549765 0.411930786391461 no 1336 0.41839520313182 1883 658262
SGTC_1292 0kpi-0043 232 µM 0.205957152073298 0.411946316322593 no 1337 0.418412190699533 1928 3333905
SGTC_440 fluspirilene 35.1 µM 0.204943015409948 0.412308458187807 no 1338 0.418808323499641 2010 3396 An atypical antipsychotic.
SGTC_540 1187-0821 17.3 µM 0.204796031386721 0.412360951467134 no 1339 0.41886574389732 1861 847520
SGTC_945 3381-0768 11.3 µM 0.204251158026009 0.412555559005598 no 1340 0.419078617783467 2047 1126236 YIL048W NEO1
SGTC_2216 7189485 200 µM 0.202451712888483 0.413198403193012 no 1341 0.419781802121528 2034 731273
SGTC_1475 4092-1048 11.7 µM 0.201483936104652 0.413544233747385 no 1342 0.420160094503447 1965 2881759
SGTC_2779 methotrexate 400 µM 0.200615484095899 0.41385462816656 no 1343 0.42049962483003 2055 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1008 4106-0037 6 µM 0.198847459809753 0.414486705879784 no 1344 0.421191034830114 1953 2905394
SGTC_2238 6671620 73.2395 µM 0.19699100594629 0.415150636003183 no 1345 0.421917288048307 2049 729941
SGTC_1691 st019933 84.6 µM 0.19683089028448 0.415207910111104 no 1346 0.421979938503402 2089 6176082
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.196649267718712 0.415272879518556 no 1347 0.422051006623525 2038 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2839 9003951 25.97 µM 0.196415834064115 0.415356386014919 no 1348 0.422142351924808 2137 2990634
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.196159224553333 0.415448187649206 no 1349 0.422242771040371 2085 16623 A steroid.
SGTC_1497 4476-2978 41.3 µM 0.196083663951328 0.415475220211279 no 1350 0.422272341168472 2016 1528379
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.195534781772819 0.415671600307968 no 1351 0.422487155619326 1914 5282362
SGTC_1724 st037281 8.293 µM 0.194806929072998 0.415932045290294 no 1352 0.422772048800317 1918 574124 YDL195W SEC31
SGTC_1662 st014054 52 µM 0.193908256858031 0.416253664953121 no 1353 0.423123859186454 2066 2838777
SGTC_3348 9149464 3.537 µM 0.192924788854837 0.416605695866737 no 1354 0.423508935509391 2074 1951442
SGTC_1527 coumarin 137 µM 0.192281624968086 0.416835951622033 no 1355 0.423760805494587 2018 323 A hepatotoxic, DNA x-linker.
SGTC_2624 nerol 100 µM 0.191747735186368 0.41702710840028 no 1356 0.423969906215276 2014 637566 A natural product oil.
SGTC_3167 9103034 49.47 µM 0.19169894965257 0.417044576814895 no 1357 0.423989014392628 2037 5127859
SGTC_772 k072-0172 35.3 µM 0.191669176704941 0.417055237559563 no 1358 0.424000675862805 1844 5861980
SGTC_1096 rimcazole 32.2 µM 0.191559327990037 0.417094571414678 no 1359 0.424043701990655 1944 18528119 A dopamine reuptake inhibitor.
SGTC_1473 k844-0725 134 µM 0.191313434122417 0.417182622368296 no 1360 0.424140018287147 2062 54682906
SGTC_2764 methyldopa 94.69 µM 0.18959127210009 0.417799419271768 no 1361 0.424814713510859 2062 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2755 lomerizine 42.69 µM 0.188229142920062 0.418287412793202 no 1362 0.425348514018008 1932 3949 A calcium channel blocker.
SGTC_948 3448-0295 75.3 µM 0.18788969362009 0.418409042793514 no 1363 0.425481561076417 1982 678569
SGTC_1770 st043884 66.3 µM 0.187007232191827 0.418725279021005 no 1364 0.425827481255747 2068 670149
SGTC_3181 9108277 49.47 µM 0.183827046386287 0.419865355187105 no 1365 0.427074568872939 1962 17097298
SGTC_1779 st039427 55 µM 0.183692716304341 0.419913526535418 no 1366 0.427127261613099 2134 1124498
SGTC_2618 avocadyne 43.43 µM 0.183356140353602 0.420034229395089 no 1367 0.427259293661753 2005 3015189
SGTC_1088 bifonazole 369 nM 0.182893005643493 0.420200331048131 no 1368 0.427440985510958 2069 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_389 tpck 16.7 µM 0.182605007506288 0.420303627747637 no 1369 0.427553977494697 1963 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2113 5491891 107.031 µM 0.181816345769863 0.420586526246515 no 1370 0.427863428129906 1941 789979
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.181748325933824 0.420610927362614 no 1371 0.427890119450119 2013 97141
SGTC_2549 cedrol 20.94 µM 0.181602380584962 0.420663284140061 no 1372 0.427947390240525 2075 6708665 A sedative which affects the nervous system.
SGTC_1364 1653-0028 37.6 µM 0.180229527963376 0.421155853086736 no 1373 0.428486189009162 1992 5718652
SGTC_2143 5623677 140.463 µM 0.179570625269645 0.421392306183213 no 1374 0.428744833706942 2074 5375313
SGTC_68 0986-0284 82.829 µM 0.17757885881047 0.422107241346366 no 1375 0.429526864431448 1790 423278 YIL048W NEO1
SGTC_1525 8-methoxypsoralen 92.5 µM 0.177540634191831 0.422120964411159 no 1376 0.429541875345049 2110 4114 Related to psoralen; DNA damaging agent.
SGTC_2995 9067767 71.4286 µM 0.176431130384092 0.422519329800211 no 1377 0.429977624868232 1986 11673567
SGTC_1371 2421-0008 32.7 µM 0.175899814748679 0.422710125835626 no 1378 0.430186325445512 1959 2827552
SGTC_2118 5526350 200 µM 0.175314465460008 0.422920346407735 no 1379 0.430416273000892 2014 743594
SGTC_795 0685-0265 78 µM 0.175290840619704 0.42292883142263 no 1380 0.430425554236362 2126 302754
SGTC_1183 1254-0324 198 µM 0.175209897972014 0.422957902771534 no 1381 0.430457353590238 2050 5799357
SGTC_340 k038-0059 454 µM 0.172230046240695 0.42402843660115 no 1382 0.431628338664416 2019 23733424
SGTC_3094 9117742 49.47 µM 0.16769298630003 0.425659483596024 no 1383 0.433412407088046 2116 17149698
SGTC_1656 st012921 11 µM 0.167623394118254 0.425684511568587 no 1384 0.433439782878492 2074 6732821
SGTC_638 3970-0837 4.09 µM 0.165942772804175 0.426289017056063 no 1385 0.43410099314159 1970 4118451 YLR208W SEC13
SGTC_168 3970-0862 530.542 µM 0.165527922286969 0.426438262043462 no 1386 0.434264237076115 2030 3135186
SGTC_2396 5342950 42.78 µM 0.165066217387389 0.426604375564291 no 1387 0.43444593141872 1983 1886677
SGTC_2008 4012253 172 µM 0.164607847225135 0.426769302182737 no 1388 0.434626327143156 2022 603940
SGTC_1333 1482-0047 286 µM 0.164566295904487 0.426784253437623 no 1389 0.434642680714757 2136 3811116
SGTC_3065 9113888 49.47 µM 0.164469957920591 0.426818918775431 no 1390 0.434680597391442 2067 16648368
SGTC_932 2857-0803 154 µM 0.163172868102653 0.427285706088529 no 1391 0.435191163998547 2119 674898
SGTC_2228 7354201 200 µM 0.161787201358127 0.427784482302535 no 1392 0.435736716046946 2077 753451
SGTC_2928 9011484 9.79 µM 0.16039050294941 0.428287346215115 no 1393 0.436286735160463 1997 2994751
SGTC_2878 9043973 25.97 µM 0.159820548510313 0.428492584739152 no 1394 0.436511218387116 2114 6465167
SGTC_503 tyrphostin 8 294 µM 0.159672996377174 0.428545720880453 no 1395 0.436569336856831 2131 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2141 5621638 7.665 µM 0.158498248438779 0.42896881458976 no 1396 0.437032100380766 2109 2856238
SGTC_1711 st032263 62.8 µM 0.15795409039354 0.429164824619186 no 1397 0.437246487515914 2059 3958979
SGTC_1843 st055809 45.5 µM 0.15769767321456 0.429257194171897 no 1398 0.437347517029022 2023 16413835
SGTC_3090 9117696 49.47 µM 0.157116176071457 0.429466682123188 no 1399 0.437576644626375 2117 7923821
SGTC_1854 st056233 32.9 µM 0.156675400096475 0.429625487639559 no 1400 0.437750337747058 2158 5393174
SGTC_101 0490-5701 117.494 µM 0.155708273344033 0.42997396996742 no 1401 0.438131487766226 2133 4661669
SGTC_2761 levamisole 97.89 µM 0.155308191118352 0.430118146549301 no 1402 0.438289179195678 2137 26879 An alkaline phosphatase inhibitor.
SGTC_1944 st076371 56.9 µM 0.154714091785724 0.430332257753428 no 1403 0.4385233600638 1953 24208455
SGTC_3112 9123419 49.47 µM 0.154253066023859 0.430498423854126 no 1404 0.438705101099687 2177 17015854
SGTC_893 0958-0369 48.9 µM 0.15415186625477 0.430534900624678 no 1405 0.438744996807369 2155 6819948
SGTC_1102 cgs 12066b 26.1 µM 0.15411981076964 0.430546454930553 no 1406 0.438757634083253 2037 6438352 A 5-HT1B full agonist.
SGTC_1801 st050089 28.441 µM 0.15260980259611 0.431090800163097 no 1407 0.43935299710185 2101 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3113 9123498 49.47 µM 0.151190070447628 0.431602721087489 no 1408 0.439912891445773 2163 8897275
SGTC_1241 0364-0022 50.8 µM 0.149934104492644 0.432055687709947 no 1409 0.440408302173859 2072 4563895
SGTC_2293 7624732 200 µM 0.149859343480428 0.432082653240756 no 1410 0.440437794304643 2086 894453
SGTC_2317 5986382 200 µM 0.147116392080176 0.433072225452238 no 1411 0.441520075824011 2099 877883
SGTC_2575 plumbagin 510 nM 0.145743121491649 0.433567817195453 no 1412 0.442062089383011 1983 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2806 7952793 58.44 µM 0.145473802604867 0.433665022420511 no 1413 0.442168399098914 2072 2972490
SGTC_852 0418-0143 439 µM 0.144963448893941 0.433849235309099 no 1414 0.442369865226853 2164 5369229
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.143130363257714 0.434511008354097 no 1415 0.443093612701797 2134 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_837 0091-0265 12.5 µM 0.14245473406139 0.434754967620898 no 1416 0.443360415817384 2024 759367
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.141206048842203 0.435205913886169 no 1417 0.443853583836357 2064 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1957 st077035 62.4 µM 0.140171577827428 0.435579563366243 no 1418 0.444262213889099 2178 705593
SGTC_1438 4092-1045 4 µM 0.139861986564172 0.435691398494195 no 1419 0.444384518168744 2126 1351342
SGTC_1754 st042065 16.137 µM 0.139519096986761 0.435815268132961 no 1420 0.444519983154856 2081 1126236 YIL048W NEO1
SGTC_246 cycloheximide 667 µM 0.137569509156555 0.436519680493013 no 1421 0.445290327263682 2054 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_193 1273-0060 1.558 µM 0.137521819300149 0.436536914012966 no 1422 0.445309173642365 2151 2847393 YHR072W ERG7
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.136538481373143 0.436892286271496 no 1423 0.445697802824 2149 6710655
SGTC_2336 9001819 198.65 µM 0.136024191571909 0.437078167734582 no 1424 0.445901078298597 2128 2989602
SGTC_254 nsc-64875 3.808 µM 0.135685735402014 0.437200504648675 no 1425 0.446034862461563 2163 56993
SGTC_766 1391-0721 126 µM 0.132793705339065 0.438246089111331 no 1426 0.44717826634104 2166 1020919 YIL115C NUP159
SGTC_1819 st053448 58.6 µM 0.131712901254167 0.438636954072153 no 1427 0.447605690350535 2092 2857616
SGTC_2657 nystatin 74.44 µM 0.13015293521806 0.439201209923863 no 1428 0.448222715004481 2137 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3268 9137683 49.47 µM 0.128965893476133 0.439630658048087 no 1429 0.448692318235118 2044 1953228
SGTC_2927 9011802 47.9 µM 0.128703930383455 0.439725440679192 no 1430 0.448795962641696 2035 43912568
SGTC_1789 tunicamycin 25 nM 0.128272392886472 0.439881585698781 no 1431 0.448966705942071 2175 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_123 0083-0120 66.675 µM 0.127829271930863 0.440041931741126 no 1432 0.449142042220522 1984 16001701
SGTC_191 3914-0123 66.505 µM 0.126193609831912 0.44063389107766 no 1433 0.449789334772314 2061 3144412
SGTC_3293 9120939 62.045 µM 0.12406551406885 0.441404264575582 no 1434 0.450631701470779 2130 934087
SGTC_726 3448-4391 34.2 µM 0.122931061352298 0.441815028764948 no 1435 0.451080844382505 2139 1356692
SGTC_2867 9039098 71.43 µM 0.122293356119482 0.442045957451269 no 1436 0.451333346777119 2190 6463460
SGTC_998 3996-0085 177 µM 0.12196307605517 0.44216556770077 no 1437 0.451464130473521 2154 715391
SGTC_2308 7584454 197.62 µM 0.120651777020793 0.442640503883536 no 1438 0.4519834281126 2165 893577
SGTC_2070 5230947 200 µM 0.119881398035124 0.442919564048079 no 1439 0.452288550204961 2200 2835538
SGTC_713 1488-1073 324 µM 0.119631366701459 0.443010140869096 no 1440 0.452387585560529 2210 3312542
SGTC_793 0488-0545 106 µM 0.11955844267265 0.44303655902609 no 1441 0.452416470727044 2012 292548
SGTC_981 1488-1094 54.9 µM 0.119116719205728 0.443196587407691 no 1442 0.452591442519594 2149 3449522
SGTC_2804 7954240 19.48 µM 0.117980449007421 0.443608279954599 no 1443 0.453041574555108 2163 828705
SGTC_2370 9071495 200 µM 0.116555342606755 0.444124709411126 no 1444 0.453606213934437 2030 21791103
SGTC_1030 k029-0042 36.7 µM 0.115516890141803 0.444501083191048 no 1445 0.454017716848555 2065 6080581
SGTC_773 4358-1457 44.6 µM 0.115085501119523 0.444657449343845 no 1446 0.454188675985581 2214 1186886
SGTC_1323 1348-1351 11.2 µM 0.114449694864416 0.444887926578049 no 1447 0.454440660979046 2070 6989654
SGTC_2799 7812892 81.82 µM 0.11342472089124 0.445259514756791 no 1448 0.454846920869527 2168 20205235
SGTC_1113 artemisinin 1.17947 µM 0.113140011571567 0.445362740188695 no 1449 0.454959776990876 2226 2240 An anti-malaria and mitochondrial poison.
SGTC_2869 9037858 32.47 µM 0.113080105979796 0.445384460288908 no 1450 0.454983523472479 2232 27187042
SGTC_143 4032-1194 15.74 µM 0.112829280024115 0.445475404578631 no 1451 0.455082952229496 2083 1806963
SGTC_995 3931-2021 34.6 µM 0.112181068339774 0.445710445969891 no 1452 0.455339919842823 2109 730143
SGTC_1671 st016596 74.5 µM 0.11213975077418 0.44572542835639 no 1453 0.455356299812293 2191 2829167
SGTC_2975 9084847 53.72 µM 0.111722470922494 0.445876744806477 no 1454 0.455521730826729 2055 27211724
SGTC_2795 7780010 54.55 µM 0.1106144888637 0.446278565912347 no 1455 0.455961028772824 2119 953673
SGTC_1514 1189-1591 158 µM 0.110530060792227 0.446309186889526 no 1456 0.455994505426786 2190 767698 YMR146C TIF34
SGTC_890 0929-0006 47.2 µM 0.110367947714929 0.446367984118058 no 1457 0.456058785911029 2040 1378169
SGTC_231 b-estradiol 524 µM 0.110158076279791 0.446444104705274 no 1458 0.456142005072603 2104 450 A steroid.
SGTC_879 0831-1030 162 µM 0.109133429120453 0.446815773580379 no 1459 0.456548330313782 2185 1549252
SGTC_3034 9090421 49.47 µM 0.10788049050512 0.447270313766948 no 1460 0.457045246556178 2210 17173761
SGTC_1334 1486-0610 236 µM 0.107447265451558 0.447427494992005 no 1461 0.457217079552053 2159 3742339
SGTC_61 0978-8327 98.565 µM 0.106856981222669 0.447641673172213 no 1462 0.45745122086357 2230 6150059 YHR072W ERG7
SGTC_516 3992-2719 87.3 µM 0.106094305208332 0.447918424425051 no 1463 0.457753764715448 2201 5350887 YDR037W KRS1
SGTC_2610 ononetin 44.17 µM 0.105798041790925 0.448025935990392 no 1464 0.457871295247795 2122 259632
SGTC_2180 6301957 200 µM 0.105110790594798 0.448275348502878 no 1465 0.458143948540476 2210 845462
SGTC_859 0439-0102 54.6 µM 0.104586043413552 0.448465799939638 no 1466 0.458352144853509 2244 610143
SGTC_3337 9144342 33.5465 µM 0.104325667148099 0.448560305161659 no 1467 0.458455454805364 2194 17682949
SGTC_23 0213-0011 39.996 µM 0.103782086169027 0.448757610738202 no 1468 0.458671141429702 2213 627608
SGTC_3035 9091303 49.47 µM 0.103149594482234 0.448987204509489 no 1469 0.458922122103 2215 25237002
SGTC_1974 st069448 26.9 µM 0.103092137282098 0.449008062256121 no 1470 0.458944922657033 2230 6323587 YNR016C ACC1
SGTC_471 1-acyl-paf 4 µM 0.102408202284514 0.449256350786732 no 1471 0.459216336710963 2170 16759367
SGTC_838 0109-0203 71.4 µM 0.102135548166219 0.449355337800395 no 1472 0.459324542592338 2220 759422
SGTC_1255 0566-0045 221 µM 0.102037528552327 0.449390924568772 no 1473 0.459363443525386 2142 2788469
SGTC_956 1185-0240 191 µM 0.101351858736072 0.449639873592567 no 1474 0.459635575387632 2152 1416193
SGTC_3086 9117350 49.47 µM 0.0995124936526816 0.450307797251986 no 1475 0.460365684318897 2234 2679265
SGTC_1561 5-methoxyflavone 52.9 µM 0.0995096642663338 0.450308824788305 no 1476 0.460366807505795 2238 94525
SGTC_1721 st082152 9.2685 µM 0.0984437118921582 0.450695965861902 no 1477 0.460789983076676 2231 5296051
SGTC_2152 5568786 200 µM 0.0983604664429389 0.450726201586827 no 1478 0.460823032808244 2216 5399883
SGTC_2859 9028643 45.46 µM 0.0973517627797048 0.451092597278489 no 1479 0.461223525211795 2193 17151580
SGTC_2891 9063876 19.48 µM 0.0972723766745001 0.451121434801787 no 1480 0.461255046086097 2266 6472478
SGTC_2589 lobaric acid 100 µM 0.0962626684068752 0.451488240407433 no 1481 0.461655979824266 2122 73157 A novel microtubule depolymerizer.
SGTC_2388 9080168 200 µM 0.095446736209578 0.451784681551633 no 1482 0.461979997684127 2197 15943073
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0921213291535884 0.45299313117254 no 1483 0.463300821146413 2129 6857784
SGTC_149 3970-0822 46.1 µM 0.0915618551430869 0.453196486573185 no 1484 0.463523079640043 2229 3114250 YBL034C STU1
SGTC_1674 st016616 23.6 µM 0.0915413117636657 0.453203953833438 no 1485 0.463531240987952 2242 625830
SGTC_344 k064-0035 6.43 µM 0.0913409042473592 0.453276800314774 no 1486 0.463610858462802 2113 5088750
SGTC_1051 3253-3903 78 µM 0.0897003264959116 0.453873195712119 no 1487 0.464262678241653 2239 5509239
SGTC_1610 st001799 48.1 µM 0.0878775272073989 0.454535955626831 no 1488 0.464987009090639 2092 621897
SGTC_2508 celastrol 40.54 µM 0.0871442692978651 0.454802600026231 no 1489 0.465278418697352 2244 122724 Celastrol is a natural product and antioxidant.
SGTC_20 0481-0013 4.944 µM 0.0860476405355891 0.455201419808271 no 1490 0.465714272982267 2205 182045
SGTC_2064 5220758 200 µM 0.0844892532749878 0.455768248591936 no 1491 0.466333723467266 2162 788518
SGTC_1148 3909-7663 27.7 µM 0.0833067559378785 0.456198415904311 no 1492 0.466803814254229 2256 4084526
SGTC_1166 k206-0078 225 µM 0.082133798285864 0.456625163609582 no 1493 0.467270158382116 2245 5404595
SGTC_2423 st077119 87.2 µM 0.0821022298299972 0.456636649599389 no 1494 0.467282709982431 2251 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1202 1988-0068 29.6 µM 0.0818131161938319 0.456741843513751 no 1495 0.467397662913417 2144 2850480
SGTC_189 3970-0742 2.116 µM 0.0809666352859071 0.457049852755911 no 1496 0.467734243272246 2277 2891807
SGTC_1966 st070145 16.1 µM 0.0806473693036891 0.457166030868549 no 1497 0.467861196804557 2257 3748532
SGTC_880 0833-0487 87.2 µM 0.0806393853671957 0.457168936200521 no 1498 0.467864371594194 2268 76075
SGTC_3285 9112818 20.8695 µM 0.0804930646812715 0.457222182290704 no 1499 0.46792255596056 2262 17017947 YPR165W RHO1
SGTC_917 harmaline 728.087 nM 0.0799990791211524 0.457401949278012 no 1500 0.468118994189805 2215 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1094 duloxetine 25.4 µM 0.0793192456944023 0.457649362670902 no 1501 0.468389349339549 2259 60834 A selective serotonin reuptake inhibitor.
SGTC_954 1189-0853 2.85 µM 0.0777018727063042 0.458238042858946 no 1502 0.469032602203988 2282 2828194
SGTC_2326 6164455 177.58 µM 0.0771223653213412 0.458448990293054 no 1503 0.469263100516444 2206 2888790
SGTC_561 1550-0330 72.9 µM 0.0770400923583353 0.458478939559342 no 1504 0.469295825317901 2202 6812934
SGTC_1260 0700-1617 7.75 µM 0.0763103929137809 0.458744577374147 no 1505 0.469586078803046 2192 2853078
SGTC_3210 9128157 49.47 µM 0.0729513221737443 0.459967640201885 no 1506 0.470922426758741 2032 17590849
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0724084760690145 0.46016533040409 no 1507 0.471138419787689 2288 88881 An O-methylated flavonoid and antioxidant.
SGTC_2923 7992654 58.14 µM 0.0721293368351118 0.460266989371414 no 1508 0.471249489802856 2217 2985126
SGTC_93 0109-0045 59.227 µM 0.0705851860885736 0.460829396224548 no 1509 0.471863950395713 2285 88733
SGTC_2260 7964312 200 µM 0.0698505395410379 0.461096994992347 no 1510 0.472156310321605 2277 231951
SGTC_2831 7999036 19.48 µM 0.0684763780417104 0.46159758755748 no 1511 0.472703211760795 2265 2988270
SGTC_2732 terfenadine 20 µM 0.0682446726131412 0.461682001421941 no 1512 0.472795433118057 2303 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2776 terbinafine 19.92 µM 0.0680145665409694 0.461765834324581 no 1513 0.472887019356773 2283 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1225 1216-0074 20.6 µM 0.0658561472522934 0.462552278014439 no 1514 0.473746177085834 2210 4241466
SGTC_1699 st031318 29.054 µM 0.0644666609492865 0.463058630212551 no 1515 0.474299326290159 2256 5340658
SGTC_370 0180-0345 38.7 µM 0.0637825269270849 0.463307962209337 no 1516 0.474571695709158 2228 3989527
SGTC_428 3448-4153 16.5 µM 0.0627653842880492 0.463678685498147 no 1517 0.474976665416674 2255 3834874
SGTC_2990 9074105 71.4286 µM 0.0620736384167624 0.463930827767256 no 1518 0.475252094999826 2313 6502001
SGTC_1504 k297-0033 30 µM 0.0618533531127835 0.464011125093079 no 1519 0.475339807574316 2283 4388117
SGTC_3297 9117502 71.43 µM 0.0614632652970727 0.464153321597663 no 1520 0.475495134558334 2325 7453720
SGTC_3327 9140648 26.9345 µM 0.060189460995022 0.46461768606721 no 1521 0.476002369702606 2285 8029710
SGTC_2116 5511452 16.8835 µM 0.0598708540934581 0.464733841550536 no 1522 0.47612924665171 2235 870744
SGTC_2708 st078559 56 µM 0.059811585689663 0.46475544954389 no 1523 0.4761528490263 2299 17250902
SGTC_3237 9133362 49.47 µM 0.0597315087963315 0.464784644032883 no 1524 0.476184738069814 2303 43845137
SGTC_987 1497-1013 404 µM 0.0597291514724117 0.464785503470537 no 1525 0.476185676829887 2294 1676435
SGTC_2092 5303694 80.6725 µM 0.0591723463445219 0.464988509140143 no 1526 0.476407417728458 2260 1963699
SGTC_1228 0124-0032 52.5 µM 0.0581819692826372 0.465349613355933 no 1527 0.476801841408993 2255 X1228
SGTC_506 n9-isopropylolomoucine 153 µM 0.0579109847584999 0.465448422783522 no 1528 0.476909766618184 2321 6610355
SGTC_3244 9134489 49.47 µM 0.0573917083942699 0.465637773123872 no 1529 0.477116583929976 2196 16584271
SGTC_1319 1306-0155 43.7 µM 0.0561775288124209 0.466080545144134 no 1530 0.477600191148626 2310 3122360
SGTC_2321 7390090 138.78 µM 0.0550413307777999 0.466494917856843 no 1531 0.478052768241296 2227 649046
SGTC_664 1222-0054 14.9 µM 0.0539978362932186 0.466875513487043 no 1532 0.478468444058158 2304 6813991
SGTC_341 1486-1430 230 µM 0.0525279247785826 0.467411688276457 no 1533 0.479054022643738 2314 2054753 YPL210C SRP72
SGTC_1827 berberine 7.24 µM 0.0518669499190203 0.467652809234272 no 1534 0.479317354478919 2297 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1967 st070177 51.4 µM 0.0513945985973246 0.467825128364511 no 1535 0.479505544390971 2289 5729214
SGTC_2568 diosmetin 100 µM 0.0488269012840777 0.468761958163779 no 1536 0.480528621806747 2326 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3315 9136395 68.55 µM 0.0480698915386956 0.469038188023765 no 1537 0.480830270763514 2319 16876844
SGTC_1837 st055472 66.5 µM 0.0479402732022606 0.469085486739884 no 1538 0.480881921449705 2282 676091
SGTC_1755 st041960 45.185 µM 0.0470620124454717 0.469405982225062 no 1539 0.481231901724265 2279 2257073
SGTC_2539 epi(13)torulosol 80 µM 0.0460476988670992 0.469776150849284 no 1540 0.481636116003686 2282 6708597
SGTC_826 1683-5028 118 µM 0.0443948651383515 0.470379400004617 no 1541 0.482294827320627 2271 722377
SGTC_600 1495-0418 41.6 µM 0.0430184491730131 0.470881814495765 no 1542 0.482843413576595 2305 5377768
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0428385550463403 0.470947482255982 no 1543 0.482915114851603 2294 17037758
SGTC_1338 1486-1223 76 µM 0.0427141804576973 0.470992883870395 no 1544 0.482964687758145 2276 3444526
SGTC_953 1188-0045 9.7 µM 0.0422382822418274 0.471166608904368 no 1545 0.483154372481172 2285 6144426
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0420402230668641 0.471238911355097 no 1546 0.483233316537697 2314 4620898
SGTC_723 4182-0001 115 µM 0.0407842512596547 0.471697431849018 no 1547 0.483733947293391 2268 744821 YLR208W SEC13
SGTC_2054 5233173 129 µM 0.0406167566673066 0.471758582330465 no 1548 0.483800712645593 2304 6889
SGTC_1121 fusaric acid 630.51 nM 0.0402385838811571 0.471896651610008 no 1549 0.483951458518773 2265 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2186 6124449 200 µM 0.0393745356583255 0.472212124597049 no 1550 0.484295890881079 2311 3834182 YLR033W RSC58
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0393691775637663 0.472214080947658 no 1551 0.484298026795413 2318 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1873 rapamycin 2 nM 0.037318010552042 0.472963053050907 no 1552 0.485115722575396 2329 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2252 omeprazole 400 µM 0.0370706458904935 0.473053383378452 no 1553 0.485214338560149 2300 4594 A proton pump inhibitor.
SGTC_134 0269-0018 6.916 µM 0.0367533569607081 0.473169250028277 no 1554 0.485340832325839 2290 4378915
SGTC_2071 5230951 39.92 µM 0.0344594863883408 0.474006985949985 no 1555 0.486255374162791 2333 1799272
SGTC_1466 k213-0079 57.5 µM 0.034138965601687 0.474124051389932 no 1556 0.486383168262828 2350 3657981
SGTC_2053 5265679 138 µM 0.0341343508340255 0.474125736881378 no 1557 0.48638500821639 2346 764595
SGTC_3263 9137018 49.47 µM 0.0334948616033441 0.474359307521349 no 1558 0.486639981690497 2314 43844957
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0330162713623379 0.474534116280955 no 1559 0.486830806022188 2338 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2226 7298446 200 µM 0.0320752263588516 0.474877854459652 no 1560 0.487206029871983 2351 3283010
SGTC_32 0928-0142 34.1 µM 0.0306045861359268 0.475415076740159 no 1561 0.487792442328478 2357 2244242
SGTC_2556 citropten 84.59 µM 0.0299749430047143 0.47564509798806 no 1562 0.48804351838716 2353 2775 A potential DNA crosslinker.
SGTC_885 0865-0106 16.8 µM 0.029834945440301 0.475696243008286 no 1563 0.488099344366385 2336 2793380
SGTC_3047 9092122 49.47 µM 0.0286198872931565 0.476140154413874 no 1564 0.48858387540708 2337 17173831
SGTC_502 l-744,832 89.3 µM 0.028576919099289 0.476155853032129 no 1565 0.488601010227876 2367 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_970 1315-0089 19.5 µM 0.0282224598162477 0.476285357696937 no 1566 0.488742362007228 2351 6811083 YLR033W RSC58
SGTC_2964 9083345 53.42 µM 0.0277307179608088 0.47646502384338 no 1567 0.48893846186476 2328 17741579
SGTC_2020 4017018 200 µM 0.0272008350249818 0.476658630828792 no 1568 0.48914977485005 2344 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3069 9117009 49.47 µM 0.0270170282339121 0.476725790874127 no 1569 0.489223076211008 2361 41904981
SGTC_2980 9014342 25.29 µM 0.0268655232024628 0.476781148873121 no 1570 0.489283496042376 2288 2996599
SGTC_831 k061-1017 217 µM 0.0257034318598668 0.477205776994286 no 1571 0.48974694326714 2351 1240153
SGTC_504 lovastatin 124 µM 0.0255587515395979 0.47725864499797 no 1572 0.489804643407738 2329 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1269 0831-0796 3.05 µM 0.0247146183649454 0.477567109797742 no 1573 0.490141297436684 2364 927758
SGTC_2640 pentamidine 10.38 µM 0.0246014819770336 0.477608453343886 no 1574 0.490186418605891 2365 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2531 methyl deoxycholate 70.07 µM 0.0238232169102862 0.477892862051707 no 1575 0.490496810443485 2341 16667744 Haematoxylin.
SGTC_2421 5690543 90.72 µM 0.0219089369389849 0.478592462954855 no 1576 0.49126029792036 2318 3397993
SGTC_377 3970-0964 33.1 µM 0.0214628762293163 0.478755491755286 no 1577 0.491438208556902 2348 16481235
SGTC_3187 9109394 49.47 µM 0.0214108576747227 0.47877450402388 no 1578 0.491458956189969 2360 17098090
SGTC_1931 st074438 57.1 µM 0.0205974931958465 0.479071786972157 no 1579 0.491783370091421 2373 2787313
SGTC_2138 5575593 77.673 µM 0.0200953813953064 0.47925531356619 no 1580 0.491983642257665 2366 762213
SGTC_1136 pergolide 1.05886 µM 0.0190099854841253 0.479652050976765 no 1581 0.492416569792746 2345 47811 A dopamine receptor agonist.
SGTC_2406 ethylparaben 405.7 µM 0.018746220992961 0.479748466083155 no 1582 0.492521777851194 2321 8434 A possible steroid mimic.
SGTC_2551 apiole 73.87 µM 0.0171489620288943 0.480332344964954 no 1583 0.493158889296824 2369 10659 A possible DNA adduct former.
SGTC_2953 9074162 66.49 µM 0.0162733477251163 0.480652444237221 no 1584 0.493508160080213 2381 16451992
SGTC_790 1575-0012 79.1 µM 0.0162525822434418 0.480660035649173 no 1585 0.493516443213375 2374 378741 YLR208W SEC13
SGTC_1583 clindamycin 39.6 µM 0.0151889972293995 0.481048868694873 no 1586 0.493940699794974 2357 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2886 9058944 51.95 µM 0.0149352317770141 0.481141644769028 no 1587 0.494041926079846 2383 4949929
SGTC_967 1306-0166 352 µM 0.0139286413520868 0.481509661959172 no 1588 0.494443455724813 2375 4437607
SGTC_2564 betulinic acid 100 µM 0.0136129632537597 0.481625079557008 no 1589 0.494569381124212 2380 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_617 3770-0098 35 µM 0.0133419685602611 0.481724161326286 no 1590 0.494677482546552 2366 5962639
SGTC_1575 cyproterone acetate 48 µM 0.0133010413367201 0.481739125340152 no 1591 0.494693808697737 2370 9880 An androgen receptor antagonist and liver toxin.
SGTC_3289 9119912 71.43 µM 0.0121213045402675 0.482170477517233 no 1592 0.495164417537706 2375 17014829
SGTC_2311 7694451 200 µM 0.011971733343761 0.482225167370688 no 1593 0.49522408348239 2367 2163142
SGTC_876 0720-0963 56.8 µM 0.0111494197439619 0.482525847587315 no 1594 0.495552117214774 2381 765861
SGTC_3212 9128307 49.47 µM 0.0108166055613787 0.48264754443368 no 1595 0.495684882855338 2359 27243542
SGTC_1442 4112-3290 3 µM 0.0105676688872722 0.48273857168473 no 1596 0.495784188542961 2384 704353
SGTC_1519 esterone 74 µM 0.0100663263325234 0.482921897477736 no 1597 0.495984184638801 2378 698 A steroid.
SGTC_903 1134-0042 114 µM 0.00924494427872084 0.483222259811907 no 1598 0.496311853384368 2378 701009
SGTC_1070 indatraline 8.81 µM 0.00916646056391525 0.483250960175201 no 1599 0.496343162529845 2386 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_492 tmb-8 126 µM 0.00889592924276151 0.483349890244329 no 1600 0.496451084510415 2387 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2974 9094440 9.66 µM 0.00752641808974931 0.483850719699556 no 1601 0.496997421951872 2373 25236134
SGTC_625 k213-0058 121 µM 0.00717397982329616 0.483979610328591 no 1602 0.49713802067886 2384 3655420
SGTC_626 0214-0009 33 µM 0.00605649901195349 0.484388296606013 no 1603 0.497583821244313 2393 3437874
SGTC_181 1447-1644 8.07 µM 0.00601896721346927 0.484402023062565 no 1604 0.497598793992674 2387 534600
SGTC_2673 kobusone 100 µM 0.00460448654449668 0.484919352595266 no 1605 0.498163082128703 2397 6710676 An epoxy ketone and protein crosslinker.
SGTC_2703 st077852 53.4 µM 0.00460121405884894 0.484920549497856 no 1606 0.49816438764776 2392 6281836
SGTC_1626 st003712 1.76 µM 0.00449885309481746 0.484957987806368 no 1607 0.498205223341448 2389 24207035
SGTC_560 2332-1943 155 µM 0.00359316925626858 0.485289245515379 no 1608 0.49856653594758 2396 21177716
SGTC_1017 4239-0030 168 µM 0.00293281207307445 0.485530780371264 no 1609 0.49882997894088 2391 1149593
SGTC_2654 protoveratrine a 100 µM 0.00270896360223534 0.485612657282737 no 1610 0.498919281204806 2396 5702278 A heart drug and vasodilator.
SGTC_3082 9117008 49.47 µM 0.00258799631649753 0.485656903661856 no 1611 0.498967540000348 2397 41448529
SGTC_1275 0867-0008 21.1 µM 0.00196040116920353 0.485886462869313 no 1612 0.499217913588005 2397 3422836
SGTC_1623 st003709 20.3 µM 0.00138529204585585 0.486096828060408 no 1613 0.499447348608964 2395 16192618
SGTC_2282 7944268 200 µM 0.000621789545456796 0.48637611033058 no 1614 0.49975194187679 2404 2970414
SGTC_3226 9131256 49.47 µM 0.000431028928060488 0.486445889878026 no 1615 0.499828044341845 2405 17178073
SGTC_375 3970-0961 9.27 µM 0.000344373727388644 0.486477588175832 no 1616 0.499862614762601 2402 2898222
SGTC_3352 9151559 45.5865 µM 0.000192718345507508 0.486533063614436 no 1617 0.499923116504244 2404 17159339
SGTC_2136 5328288 199.296 µM 3.84427646739012e-05 0.486589497787479 no 1618 0.4999846635558 2404 262395
SGTC_731 3966-0296 387 µM -0.00019095146341372 0.486673410938508 no 1619 0.499923821388203 2405 660956
SGTC_1882 5615643 20 µM -0.000337846487917644 0.486727145924005 no 1620 0.499865218754248 2407 2253075
SGTC_2957 9076800 11.52 µM -0.000429326817012991 0.486760610039414 no 1621 0.499828723385845 2410 16459615
SGTC_2722 naftopidil 47.16 µM -0.000466695698633306 0.486774279852741 no 1622 0.499813815360492 2400 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_754 3474-0146 171 µM -0.00107466944170307 0.486996683316941 no 1623 0.499571269004774 2408 24762078
SGTC_74 000s-0487 160.283 µM -0.00159659819276645 0.487187613807977 no 1624 0.499363049746704 2409 677548
SGTC_58 0957-0393 9 µM -0.00169552284347816 0.487223802474691 no 1625 0.499323584574443 2404 6997992
SGTC_1419 3993-2473 62.6 µM -0.00192880349277324 0.487309141738082 no 1626 0.499230519213261 2410 704026
SGTC_541 4513-1321 94 µM -0.00216310475235234 0.487394854948405 no 1627 0.499137046730312 2411 747515
SGTC_1978 st071761 42 µM -0.00265012782525025 0.487573021922815 no 1628 0.498942753199578 2410 5147680
SGTC_1886 st057356 49.9 µM -0.00291571888015409 0.487670183776928 no 1629 0.498836798109086 2413 24207747
SGTC_2936 9038235 15.59 µM -0.0071122916423883 0.489205520075396 no 1630 0.497162630074573 2418 4749415
SGTC_2898 9056270 58.44 µM -0.00753363239492532 0.489359678826912 no 1631 0.496994543942108 2421 19154699
SGTC_2583 asiatic acid 100 µM -0.00760775718973077 0.489386799525084 no 1632 0.496964973274881 2431 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2198 6589944 200 µM -0.00769864350115871 0.48942005297543 no 1633 0.496928715944393 2428 5290268
SGTC_1730 st033808 45.1 µM -0.00774846907318688 0.489438283168704 no 1634 0.496908839009939 2435 1045166
SGTC_2237 6667747 47.222 µM -0.00785105741710389 0.489475818288146 no 1635 0.496867913426992 2428 729940 YDL015C TSC13
SGTC_2835 9006588 71.43 µM -0.00885696408435517 0.489843865248412 no 1636 0.496466628747177 2450 2345538
SGTC_3302 9125395 16.351 µM -0.00900376742965103 0.489897579237659 no 1637 0.496408065021204 2440 17599668
SGTC_347 4534-1311 26.2 µM -0.00911531899282573 0.489938395047711 no 1638 0.496363564212479 2419 2862016
SGTC_2992 9074591 71.4286 µM -0.0099839006173062 0.490256205573649 no 1639 0.496017066089202 2414 17741321
SGTC_1397 3532-0190 20.1 µM -0.0100407001990725 0.490276988530049 no 1640 0.495994407470277 2420 5322280
SGTC_1381 2324-0066 62.1 µM -0.0109617061901921 0.490613988095279 no 1641 0.495626999511466 2443 10885928
SGTC_3160 9100216 49.47 µM -0.0109691618021883 0.490616716159487 no 1642 0.495624025331428 2428 17191039
SGTC_1829 berberine 14.4 µM -0.0110436875062057 0.490643985696242 no 1643 0.495594295677926 2438 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2389 9091542 195.52 µM -0.012294857906437 0.491101805140523 no 1644 0.495095184921433 2449 3626624 YOL127W RPL25
SGTC_2879 9041815 71.43 µM -0.0125315980245349 0.491188432751271 no 1645 0.495000746555278 2428 4942971
SGTC_1188 1403-0014 4.57 µM -0.0131031969311254 0.491397593123746 no 1646 0.494772730317782 2430 9614867
SGTC_2398 5228213 48.84 µM -0.0149219240888504 0.492063120089149 no 1647 0.494047234487753 2428 80771 YMR134W ERG29
SGTC_1760 st045453 10.4495 µM -0.0158706187063594 0.492410284867523 no 1648 0.493668804962934 2424 3323419 YIL048W NEO1
SGTC_1951 sophoraflavanone G 9.2 µM -0.0161968978639729 0.492529684622089 no 1649 0.49353865514295 2433 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2182 6325192 200 µM -0.016749212144157 0.492731801992571 no 1650 0.493318343521393 2439 736248
SGTC_3182 9108849 49.47 µM -0.0170622187428152 0.492846346432776 no 1651 0.493193489798726 2450 17133045
SGTC_368 fentichlor 4.58 µM -0.0173822348636203 0.492963456610095 no 1652 0.493065840770351 2452 7329 A pesticide.
SGTC_2711 st079103 59.1 µM -0.0176312966144525 0.493054601394306 no 1653 0.492966494733064 2455 54693780
SGTC_1097 itavastatin 7.23 µM -0.0182107904939269 0.493266670055614 no 1654 0.492735347247624 2454 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2424 5537928 59.2 µM -0.0184677288780766 0.493360698545024 no 1655 0.492632860898997 2438 5382802
SGTC_1629 st005085 44.9 µM -0.0185423599017223 0.493388010385811 no 1656 0.49260309252557 2435 24207091
SGTC_2506 ethyl hematommate 54.16 µM -0.0188239429642143 0.493491058316076 no 1657 0.492490776741061 2466 3940691 An allergen.
SGTC_98 0074-0023 107.663 µM -0.0189279069027632 0.493529104992651 no 1658 0.492449308518588 2460 3563821
SGTC_161 4065-0411 162.148 µM -0.0195138418768787 0.493743535036044 no 1659 0.492215597462519 2454 1906281 YLR208W SEC13
SGTC_2041 5107442 45.335 µM -0.0198310353288115 0.493859616602954 no 1660 0.492089080067798 2441 793005
SGTC_2536 dehydroabietamide 32.04 µM -0.0217454537487287 0.494560236616113 no 1661 0.491325502742514 2455 3983547
SGTC_2266 7929956 200 µM -0.0234877562592644 0.495197881983688 no 1662 0.490630602440925 2434 2967153
SGTC_2257 7960413 200 µM -0.0235354731297368 0.495215345515375 no 1663 0.490611571424669 2479 2974689 YIL048W NEO1
SGTC_675 1309-0189 238 µM -0.0249247894242825 0.495723814619831 no 1664 0.490057477136523 2473 4246530
SGTC_1207 2099-0101 141 µM -0.0253225477264325 0.495869389559062 no 1665 0.489898844605687 2454 5837381
SGTC_1603 st002045 67.8 µM -0.0268009231009263 0.496410462518992 no 1666 0.489309258477765 2459 5887985
SGTC_2760 etidronate 98.04 µM -0.0273220127989258 0.496601178593348 no 1667 0.489101449873149 2473 3305 A chelator and antioxidant.
SGTC_2127 5253358 187.912 µM -0.0274784320551843 0.496658427367686 no 1668 0.489039071038965 2458 20612
SGTC_1436 4092-1007 8.32 µM -0.0284864303324595 0.497027351996583 no 1669 0.488637095332207 2459 2881121
SGTC_401 neomycin 50 µM -0.0298038764332513 0.497509537471594 no 1670 0.488111733597447 2486 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1985 st071382 65.5 µM -0.0301330011789477 0.497629997774512 no 1671 0.487980490769761 2458 6123237
SGTC_1385 3091-4834 14.1 µM -0.0303726389336567 0.497717705799657 no 1672 0.487884932876538 2485 4072814
SGTC_509 pifithrin 175 µM -0.0305470051703593 0.497781524353481 no 1673 0.487815403074914 2457 4817 A p53 inhibitor.
SGTC_1983 st071813 46.9 µM -0.030834801423378 0.497886858749228 no 1674 0.487700643042617 2511 11838595
SGTC_3070 9117005 49.47 µM -0.0310560700266457 0.497967843902157 no 1675 0.487612411897697 2454 8779016
SGTC_3216 9129716 49.47 µM -0.0312863309557292 0.498052120369511 no 1676 0.487520595694921 2477 8056934
SGTC_303 1348-1668 34.2 µM -0.034252601681518 0.499137794357119 no 1677 0.486337860524113 2485 5380509
SGTC_966 1300-0360 30.2 µM -0.0356058597497461 0.499633098038671 no 1678 0.485798317940734 2486 70588
SGTC_2481 5478948 45.16 µM -0.0376107408233183 0.499633098038671 no 1679 0.48499902202184 2519 77792
SGTC_2312 7706453 155.7 µM -0.0378976711274123 0.499528079093573 no 1680 0.484884634943988 2490 976098
SGTC_1788 fluconazole 20 µM -0.0384429419633675 0.499328505400656 no 1681 0.484667261766989 2546 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3316 9136639 10.545 µM -0.0387184581368576 0.499227664234328 no 1682 0.484557428489014 2556 4903665
SGTC_2567 aureobasidin a 60 nM -0.0401987901258139 0.498685851659932 no 1683 0.483967321095887 2591 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3108 9121785 49.47 µM -0.0412312975190706 0.498307947610622 no 1684 0.483555751534046 2458 17140271
SGTC_2002 4023503 131 µM -0.0412469830581224 0.498302206617812 no 1685 0.483549499228133 2464 4736863 YCR052W RSC6
SGTC_1432 4049-0298 68.4 µM -0.0417045655672372 0.498134729084402 no 1686 0.483367107166598 2497 741646
SGTC_392 N-ethylmaleimide 8.33 µM -0.0418428184608732 0.498084127883132 no 1687 0.483312000344806 2499 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1787 fluconazole 80 µM -0.0419539167746281 0.498043465406533 no 1688 0.483267717416001 2508 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_226 1,3-diallylurea 8.28947 mM -0.0437944417703449 0.497369828354728 no 1689 0.48253412882999 2547 74537 YKL182W FAS1
SGTC_1187 1391-0724 117 µM -0.043923860076015 0.497322461169872 no 1690 0.482482548030963 2507 6997986
SGTC_1191 1487-1166 10.6 µM -0.0447857686370119 0.497007003065526 no 1691 0.48213903434676 2571 3955771
SGTC_115 0527-0192 112.043 µM -0.0462984540902609 0.496453365587008 no 1692 0.481536185723523 2532 4233931
SGTC_290 2043-6722 48.1 µM -0.0472686145147597 0.496098293861419 no 1693 0.481149571049744 2526 773758 YLR208W SEC13
SGTC_406 estrone 100 µM -0.0475238236702357 0.496004889651254 no 1694 0.481047871620609 2497 5870 A steroid.
SGTC_1284 0929-0043 16 µM -0.0481390697935399 0.495779716123381 no 1695 0.480802704545916 2542 1239883
SGTC_1927 st060202 13.8 µM -0.0484512251855938 0.495665471084447 no 1696 0.480678317708346 2483 688887
SGTC_1860 st056228 74.6 µM -0.0498131525560131 0.495167026678835 no 1697 0.480135642735878 2595 688679
SGTC_840 0245-0196 390 µM -0.0517932520343806 0.494442354488241 no 1698 0.479346716216484 2603 3827528
SGTC_3103 9120822 49.47 µM -0.052674469140287 0.494119854461284 no 1699 0.4789956407259 2510 17141819
SGTC_2339 9000433 200 µM -0.0528267409658674 0.49406412775154 no 1700 0.478934977516884 2547 2988954
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0534348689451685 0.493841573160612 no 1701 0.478692711743103 2551 5393153
SGTC_3106 9121286 49.47 µM -0.0546552790454209 0.493394949554696 no 1702 0.47820654911245 2670 15943471
SGTC_301 4119-0100 24.5 µM -0.0547726370990496 0.493352001405241 no 1703 0.478159800049733 2511 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1502 4534-4282 27.7 µM -0.0549446324061643 0.493289058440773 no 1704 0.478091287021327 2521 3278949
SGTC_2204 7233102 200 µM -0.0568630980318345 0.492586993332653 no 1705 0.477327125115697 2498 2172480
SGTC_2692 st077426 47.7 µM -0.0571988561358684 0.492464124496823 no 1706 0.477193394670874 2512 25238571
SGTC_50 0929-0078 56.389 µM -0.0582749097762693 0.4920703534468 no 1707 0.476764826320531 2610 1377751
SGTC_1204 4049-0315 18.3 µM -0.0583998518517345 0.492024632639305 no 1708 0.476715066388884 2747 588402
SGTC_1509 1326-1131 80 µM -0.0588365541996608 0.491864828341412 no 1709 0.476541146419209 2493 768313
SGTC_2096 5468907 200 µM -0.0588482435033165 0.491860550843966 no 1710 0.476536491128038 2559 759785
SGTC_419 nsc-638432 893 µM -0.0601770486561068 0.491374303921809 no 1711 0.476007312549731 2556 368090
SGTC_2491 paeonol 100 µM -0.0605814574877789 0.491226321945022 no 1712 0.475846270588665 2511 11092 Increases levels of cortical cytochrome oxidase.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0606130605189948 0.491214757759971 no 1713 0.475833685930157 2530 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1145 3546-0597 10.2 µM -0.06158639272859 0.490858599581853 no 1714 0.47544610670061 2561 875334
SGTC_659 k018-0002 107 µM -0.0629797560706882 0.490348757896757 no 1715 0.474891312314544 2532 6797879 YHR007C ERG11
SGTC_438 sphingosine 6.67 µM -0.0649617650240734 0.489623553911768 no 1716 0.474102221506415 2540 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1251 0490-5699 265 µM -0.0654411957741458 0.489448138428243 no 1717 0.473911362436183 2534 3883818
SGTC_784 4579-0127 173 µM -0.0658463457494 0.489299902595222 no 1718 0.473750078850791 2710 1948547
SGTC_2084 5306078 60.6385 µM -0.0671369493030143 0.488827707920873 no 1719 0.473236339474388 2580 679340
SGTC_2733 amorolfine 100 µM -0.0681658320926304 0.488451280523279 no 1720 0.472826812861539 2555 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3317 9138495 8.753 µM -0.0683662018427585 0.488377974366575 no 1721 0.472747062940548 2524 17020139
SGTC_908 3448-7491 47.7 µM -0.0686082063932014 0.488289436458282 no 1722 0.472650743252268 2522 1203031
SGTC_559 1550-0661 158 µM -0.0689363173471276 0.488169397251374 no 1723 0.472520155102526 2589 5830875
SGTC_1955 wogonin 32.4 µM -0.0692991922127714 0.488036640935543 no 1724 0.472375734357261 2750 5281703 A flavanone.
SGTC_485 niflumic acid 177 µM -0.0695560391477486 0.487942675313681 no 1725 0.472273513913878 2629 4488 A COX2 inhibitor.
SGTC_1807 st050092 58.9 µM -0.0696979385259843 0.487890762723478 no 1726 0.472217041305698 2536 5008496
SGTC_1194 1488-0194 225 µM -0.0699071703292021 0.487814217555735 no 1727 0.472133772998552 2524 1391452
SGTC_1348 1493-0373 93.8 µM -0.0701861244990125 0.487712165921095 no 1728 0.47202275906737 2572 3010129
SGTC_744 1594-0068 283 µM -0.0704470681005355 0.487616703939052 no 1729 0.471918914675156 2539 668392
SGTC_4 0960-0234 25.671 µM -0.0732243346418799 0.486600731093466 no 1730 0.470813801060307 2563 6821112
SGTC_1642 st009582 77.7 µM -0.0736114581643606 0.486459121269732 no 1731 0.470659776790142 2560 6739311
SGTC_2978 9011784 42.97 µM -0.0739289243739243 0.486342993371547 no 1732 0.470533470247784 2691 2994934
SGTC_447 ml7 120 µM -0.074699520710203 0.486061117081444 no 1733 0.470226894513686 2554 4216 Selective myosin light chain kinase inhibitor.
SGTC_3101 9120531 49.47 µM -0.0749651223012343 0.485963964331711 no 1734 0.470121231075255 2551 24824904
SGTC_2768 sulfasalazine 50.2 µM -0.0782903941361963 0.484747706261183 no 1735 0.468798529189478 2555 5384001 An antioxidant and salicylic acid derivative.
SGTC_323 4013-0906 34.3 µM -0.0785686413148857 0.484645940293611 no 1736 0.468687865506418 2653 2910086
SGTC_2315 7733312 200 µM -0.0793351723438542 0.484365594856096 no 1737 0.468383015485939 2583 726316
SGTC_2393 9031399 185.94 µM -0.0795933249062013 0.484271181763738 no 1738 0.468280352163748 2607 1526623 YDL150W RPC53
SGTC_3062 9077494 49.47 µM -0.0796877943428866 0.48423663205892 no 1739 0.468242783641785 2590 16459633
SGTC_1303 1160-0052 261 µM -0.0807846333797744 0.483835500841701 no 1740 0.467806614454977 2546 3562476
SGTC_2294 7971431 200 µM -0.0814353454228036 0.483597532960222 no 1741 0.467547870431093 2634 5741572
SGTC_2239 6685329 187.64 µM -0.0820913114354573 0.483357649595732 no 1742 0.467287051137538 2704 805680
SGTC_390 dec-rvkr-cmk 16.7 µM -0.0829900663317992 0.483028989395748 no 1743 0.466929719142519 2606 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2899 9053889 58.44 µM -0.0830207803662731 0.483017757970194 no 1744 0.466917508154353 2551 6470052
SGTC_1683 st010134 710 nM -0.0834281025066716 0.482868810782813 no 1745 0.466755571914237 2545 3818134
SGTC_1486 3970-0793 4.53 µM -0.0839062762666865 0.482693958040345 no 1746 0.466565474710652 2647 2844330
SGTC_644 1498-1197 63.3 µM -0.0841236658650115 0.482614466764763 no 1747 0.466479054347306 2622 6741615
SGTC_2433 5607874 27.82 µM -0.0855362047135692 0.482097970918803 no 1748 0.465917556864412 2558 2252428
SGTC_694 1315-0438 43.2 µM -0.0856828397893051 0.482044355404451 no 1749 0.465859271909716 2599 6793154
SGTC_1783 st039459 87.517 µM -0.089369022637641 0.48069665214743 no 1750 0.464394320645987 2757 729761
SGTC_2013 4024628 200 µM -0.089700642000163 0.480575419564083 no 1751 0.464262552879029 2670 5230760
SGTC_1563 conessine 56.1 µM -0.0926414351212251 0.479500411608798 no 1752 0.463094212404201 2622 441082 An anti-amoebic, histamine inhibitor.
SGTC_738 1315-0003 72.4 µM -0.092913773340527 0.479400865700723 no 1753 0.462986031769991 2637 6251474
SGTC_883 0850-0245 24.6 µM -0.0939427804300959 0.479024751497765 no 1754 0.46257730510692 2762 6823229 YPR165W RHO1
SGTC_1060 3448-7350 82 µM -0.0960600548302642 0.478250921905037 no 1755 0.461736438086053 2613 570178
SGTC_3199 9111318 49.47 µM -0.0961157404072574 0.478230570819852 no 1756 0.461714325074415 2647 8548020
SGTC_3098 9119039 49.47 µM -0.0961877687484638 0.478204247123523 no 1757 0.461685722447721 2562 17161528
SGTC_2912 7964298 10.93 µM -0.0967013347421462 0.478016560498456 no 1758 0.461481789914705 2639 2975850
SGTC_946 3434-1334 87.4 µM -0.0973310657117883 0.477786427151958 no 1759 0.461231743121107 2691 4047976
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0983566085521786 0.477411661399372 no 1760 0.46082456445714 2633 551469
SGTC_3301 9125354 19.7965 µM -0.0993651251537332 0.477043137051015 no 1761 0.46042418589367 2580 41905162
SGTC_1808 st050063 61.5 µM -0.0996065767393828 0.476954910578039 no 1762 0.460328336156574 2580 4011993
SGTC_1315 1237-0019 3.69 µM -0.0999619360150604 0.476825064260988 no 1763 0.460187272347513 2614 825140
SGTC_3044 9093193 49.47 µM -0.101217410379617 0.476366340656329 no 1764 0.459688938105554 2678 25236277
SGTC_35 0133-0054 64.071 µM -0.101548258174027 0.476245461105022 no 1765 0.459557625516507 2609 99677
SGTC_2665 lovastatin 100 µM -0.103646208721109 0.475478998885195 no 1766 0.45872505792763 2604 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1403 3909-7815 62.9 µM -0.104078152384061 0.47532120438185 no 1767 0.458553664278469 2582 6615483
SGTC_1501 4491-0275 38.4 µM -0.104199476321125 0.475276883902721 no 1768 0.458505524773264 2591 5104718
SGTC_132 0417-1715 25.805 µM -0.104237841779519 0.475262868797224 no 1769 0.458490302065635 2616 6769098
SGTC_656 4090-1979 187 µM -0.104247765830669 0.47525924349367 no 1770 0.458486364394737 2609 22330961
SGTC_2043 5101342 149 µM -0.1050019390136 0.474983746421734 no 1771 0.458187135058354 2621 678451
SGTC_452 diindolylmethane 8 µM -0.105757941371577 0.474707593162327 no 1772 0.457887203751123 2681 3071 Inhibits expression of several cancer promoting factors.
SGTC_424 splitomicin 100 mM -0.10632652157208 0.474499909645335 no 1773 0.457661644844131 2689 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3021 9087658 49.47 µM -0.106658516402177 0.474378646129604 no 1774 0.457529946961586 2595 25237042
SGTC_1154 4088-0362 150 µM -0.106760439030252 0.474341418627367 no 1775 0.457489516561184 2589 6618304
SGTC_732 3970-1727 52.7 µM -0.107652852513734 0.474015471910354 no 1776 0.457135535159823 2671 1275699
SGTC_2698 st077697 67.5 µM -0.10767693141602 0.474006677528484 no 1777 0.457125984582211 2628 3154499
SGTC_311 1315-0136 58 µM -0.108247249094201 0.473798383064139 no 1778 0.456899782881413 2729 6759207
SGTC_2797 7859098 81.82 µM -0.108903661131538 0.473558653628953 no 1779 0.456639451378055 2634 972681
SGTC_2314 7727897 200 µM -0.109166138998747 0.473462796284374 no 1780 0.456535358462162 2617 900724
SGTC_2716 st080858 38.6235 µM -0.109994457155844 0.473160303246445 no 1781 0.456206885395415 2639 5296050
SGTC_2888 9058547 12.99 µM -0.110139956577583 0.47310716998828 no 1782 0.456149190068367 2624 16476514
SGTC_2332 7982454 138.89 µM -0.110557156328864 0.472954820272049 no 1783 0.455983761716038 2580 2981748
SGTC_2328 6201408 200 µM -0.110638095368768 0.472925264049048 no 1784 0.455951668591233 2672 2890418
SGTC_2832 7992762 51.95 µM -0.11117408241421 0.472729543324571 no 1785 0.455739151722705 2604 2985177
SGTC_2413 inermin 26.06 µM -0.111786605008215 0.47250588298677 no 1786 0.455496304302011 2858 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3145 9085516 49.47 µM -0.112969978707002 0.472073803113689 no 1787 0.455027178168436 2676 25236195
SGTC_1503 4585-0012 61.3 µM -0.113320973422423 0.471945652301079 no 1788 0.45488804497786 2798 2922052
SGTC_1222 0366-0074 1.18 µM -0.114067363337124 0.471673149396234 no 1789 0.454592196803155 2700 286520
SGTC_943 3253-1379 105 µM -0.114956632649988 0.47134849932072 no 1790 0.454239748108643 2722 668464
SGTC_2916 7875993 68.79 µM -0.115135727625484 0.471283118502497 no 1791 0.454168770822797 2622 1299250
SGTC_278 4092-0821 23.9 µM -0.116870163153231 0.470649981836944 no 1792 0.453481471222429 2693 877900
SGTC_693 4161-2696 114 µM -0.118415149209741 0.470086064044925 no 1793 0.452869361448364 2731 805759
SGTC_2461 5755302 26.15 µM -0.119491078399074 0.469693386733452 no 1794 0.452443153901436 2782 2788904
SGTC_2094 5332512 191.667 µM -0.119840124998346 0.469566002990336 no 1795 0.452304897911095 2723 755774
SGTC_2158 5657123 3.6195 µM -0.121232722171331 0.469057809030703 no 1796 0.451753353355681 2587 2858827
SGTC_2120 5538279 151.968 µM -0.121796529522184 0.468852075745132 no 1797 0.451530081264338 2643 2058197
SGTC_1272 0839-0021 27 µM -0.123336537781279 0.46829016932266 no 1798 0.450920304365707 2696 5027250
SGTC_3197 9113331 49.47 µM -0.124747448735862 0.467775422354442 no 1799 0.450361746055033 2763 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_579 4491-1009 110 µM -0.125102523321305 0.467645887856963 no 1800 0.450221192835635 2619 1271041
SGTC_2012 4023501 200 µM -0.125296128489101 0.467575260340959 no 1801 0.450144558524899 2685 3477460
SGTC_1423 4048-0112 5.59 µM -0.125662992925129 0.46744143033147 no 1802 0.449999348477509 2709 X1423
SGTC_992 3909-8734 162 µM -0.128518042414252 0.466400051834937 no 1803 0.448869510420634 2677 4288319
SGTC_237 nikkomycin 200 µM -0.128885872455271 0.46626590250506 no 1804 0.448723977786542 2760 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3331 9141060 1.957 µM -0.129126229495723 0.466178245241926 no 1805 0.448628883806116 2649 4906567 YPR165W RHO1
SGTC_1500 4488-1866 171 µM -0.129947780280315 0.465878641330199 no 1806 0.448303870775334 2778 2900003
SGTC_2743 auranofin 4.32 µM -0.130436929428461 0.465700267132832 no 1807 0.448110375347821 2679 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2123 5259487 200 µM -0.13055301772138 0.465657935132632 no 1808 0.448064455472145 2726 2173474
SGTC_2108 5365811 200 µM -0.130747454780469 0.465587033852782 no 1809 0.447987545524206 2725 780283
SGTC_2469 5655019 90.81 µM -0.131291873413107 0.465388517959243 no 1810 0.447772210110839 2799 2788239
SGTC_1373 2887-0003 58.5 µM -0.131837011504102 0.465189748353759 no 1811 0.4475566055498 2728 776948
SGTC_3030 9087619 49.47 µM -0.132430329727139 0.464973421060939 no 1812 0.447321963141968 2658 25236973
SGTC_2133 5320837 200 µM -0.132488752404447 0.464952120370048 no 1813 0.447298859440851 2757 2841355
SGTC_2027 5150920 200 µM -0.133733453545317 0.464498330923393 no 1814 0.446806675331198 2725 786715
SGTC_882 0843-0131 351 µM -0.135124606279137 0.463991203259169 no 1815 0.44625667779811 2625 5425421
SGTC_582 0987-0078 156 µM -0.135203761942408 0.46396234978429 no 1816 0.446225386403628 2658 1625765
SGTC_2612 dictamnine 15.46 µM -0.135261459461478 0.463941318257356 no 1817 0.446202577939227 2746 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2987 9018338 71.43 µM -0.136337427874899 0.463549131725278 no 1818 0.44577726847302 2614 5055682
SGTC_3218 9131285 49.47 µM -0.138146696005471 0.46288974019248 no 1819 0.44506224073532 2702 17156417
SGTC_2742 clothiapine 36.27 µM -0.139218127222394 0.462499302807235 no 1820 0.444638892270493 2646 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_687 k029-0044 34.9 µM -0.139469109391349 0.462407848275005 no 1821 0.444539732237605 2729 5829338
SGTC_3186 9110464 49.47 µM -0.139595870116006 0.46236165912406 no 1822 0.444489651920444 2769 17018021
SGTC_3295 9122362 53.5725 µM -0.139717035871931 0.46231750914569 no 1823 0.444441782878208 2736 4730473
SGTC_3229 9132204 49.47 µM -0.140721466902664 0.4619515358077 no 1824 0.444044992856592 2638 17682924
SGTC_776 4476-4378 112 µM -0.14084087514769 0.461908030492856 no 1825 0.443997825594625 2751 2892008
SGTC_1267 0828-0272 9.49 µM -0.142028594094853 0.461475320725921 no 1826 0.443528709904257 2753 745334
SGTC_2679 rapamycin 1 nM -0.142093044056525 0.461451841615665 no 1827 0.443503256233589 2697 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1177 0983-0204 23.6 µM -0.142731095510868 0.461219406839683 no 1828 0.44325127873785 2762 766818
SGTC_1922 5578187 25 µM -0.14298043796986 0.46112857785704 no 1829 0.443152815341536 2891 1350412
SGTC_2479 5617353 43.85 µM -0.143060384658803 0.461099455783467 no 1830 0.443121245759228 2783 2731746
SGTC_2973 9094665 17.96 µM -0.143364899555459 0.460988532460817 no 1831 0.443001001334942 2901 25237061 YIL048W NEO1
SGTC_2046 4110841 106 µM -0.145208609898384 0.460317003261699 no 1832 0.4422730841351 2711 44119630 YMR134W ERG29
SGTC_2845 9003024 42.97 µM -0.14542410994801 0.460238519662129 no 1833 0.442188015008295 2886 2990173
SGTC_2056 5235370 200 µM -0.145453174235572 0.460227934771882 no 1834 0.442176542019681 2709 5511916
SGTC_791 1348-1292 225 µM -0.14621501138542 0.459950492230153 no 1835 0.44187582777201 2740 5437054
SGTC_299 1273-0059 1.44 µM -0.146412886616343 0.459878434073306 no 1836 0.441797727443386 2747 2848077
SGTC_325 2810-4341 181 µM -0.147443118668952 0.459503286568318 no 1837 0.44139113681419 2783 774970
SGTC_477 mead ethanolamide 10 µM -0.148041183390483 0.459285524492909 no 1838 0.441155133332297 2648 16061185
SGTC_1153 4055-0057 267 µM -0.148184491567623 0.45923334618941 no 1839 0.441098585314149 2672 882706
SGTC_1134 3477-0009 42.5 µM -0.148535455992537 0.45910556350908 no 1840 0.440960103226574 2918 3973534
SGTC_2794 7785382 27.27 µM -0.148635515454596 0.459069133620723 no 1841 0.440920623500627 2645 2205081
SGTC_94 0334-0113 514.748 µM -0.148747389327797 0.459028402720291 no 1842 0.440876482944634 2683 6795178
SGTC_769 0302-0231 76 µM -0.148799942087432 0.459009269525459 no 1843 0.440855748168953 2742 571869 YER009W NTF2
SGTC_454 lyso-paf C-16 6.67 µM -0.149847450060469 0.45862791695284 no 1844 0.440442486116114 2737 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3104 9120930 49.47 µM -0.1501663521266 0.458511825978625 no 1845 0.44031668597319 2741 17014836
SGTC_1293 1000-1278 195 µM -0.151076667286771 0.458180460439829 no 1846 0.439957619015464 2783 678847
SGTC_1906 st060206 94.7 µM -0.151304745019741 0.458097441977947 no 1847 0.439867663196015 2763 5133468
SGTC_1242 0402-0103 60.1 µM -0.151964225644555 0.457857406627259 no 1848 0.439607575846661 2676 432868
SGTC_1223 0764-0573 147 µM -0.152877292817493 0.457525097159825 no 1849 0.439247521551239 2682 1609797
SGTC_3259 9138485 49.47 µM -0.153157376349353 0.457423167106894 no 1850 0.439137084885267 2893 17646153
SGTC_3335 9143315 29.6265 µM -0.154178004382766 0.457051756415024 no 1851 0.438734692385156 2742 4899691
SGTC_1763 st044482 94.5 µM -0.154712587616152 0.456857234351234 no 1852 0.438523953001659 2810 88505
SGTC_2730 imipramine 71.33 µM -0.155020682275221 0.456745130759863 no 1853 0.438402506154391 2687 3696 A tricyclic antidepressant.
SGTC_3137 9097352 49.47 µM -0.155568708791937 0.456545733866549 no 1854 0.43818649567822 2974 44120435
SGTC_2220 6782180 200 µM -0.155904156606963 0.456423688137993 no 1855 0.438054284438496 2689 833803
SGTC_293 4049-0273 38.5 µM -0.157918450640184 0.455690915896906 no 1856 0.437260529493131 2708 1380311
SGTC_2861 9024595 19.48 µM -0.158060831365763 0.455639125436607 no 1857 0.437204432302221 2741 16482810
SGTC_604 1000-0114 314 µM -0.158523075157713 0.455470991174274 no 1858 0.437022319602077 2799 1572745
SGTC_2458 5808907 16.39 µM -0.159575419092075 0.4550882466079 no 1859 0.436607771770408 2702 2731747
SGTC_2256 7954252 200 µM -0.160036711806934 0.454920484465918 no 1860 0.43642607753179 2763 2972920
SGTC_1640 st009078 66.4 µM -0.160116093077319 0.454891616031856 no 1861 0.436394812143186 2818 690618
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.160205657336283 0.454859044655943 no 1862 0.436359536523728 2685 16486 A toxic proline analog.
SGTC_1355 1499-0035 1.68 µM -0.161392400616912 0.454427496533162 no 1863 0.435892175821494 2704 1548538
SGTC_1669 st015249 58.4 µM -0.161946435371756 0.454226045349434 no 1864 0.435674017646482 2745 722793
SGTC_819 1013-0258 27.7 µM -0.162100581273569 0.454169998837267 no 1865 0.435613324230412 2702 5753198
SGTC_1698 5-fluorocytosine 1.055 µM -0.163572927657406 0.453634708793778 no 1866 0.435033679106314 2724 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_384 k007-0144 5.16 µM -0.163890569523664 0.453519237110295 no 1867 0.434908645573811 2768 6824886
SGTC_3206 9114350 49.47 µM -0.164555806703868 0.453277417572875 no 1868 0.434646809022239 2798 17087243
SGTC_234 nsc-17383 10.7 µM -0.165492770747349 0.452936852346435 no 1869 0.434278069744212 2743 408974
SGTC_751 0833-0568 350 µM -0.166309084046272 0.452640169142699 no 1870 0.433956858783107 2773 6954252
SGTC_2737 bleomycin 30.5 nM -0.16677491500588 0.452470878064982 no 1871 0.433773578577513 2717 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_690 glyoxal 20.3 µM -0.166948853311929 0.452407668071198 no 1872 0.433705146567707 2710 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1891 st059073 26.2 µM -0.1682030039247 0.451951939674018 no 1873 0.433211788912963 2883 688754
SGTC_2135 5326629 150.42 µM -0.168679058628664 0.451778969300362 no 1874 0.433024545763072 2749 5020077
SGTC_1175 0741-0056 27.6 µM -0.168901191870216 0.451698262231644 no 1875 0.432937180845561 2880 765927
SGTC_1387 3342-1166 1.8 µM -0.169436705341328 0.451503703786976 no 1876 0.432726577089558 2792 3418228
SGTC_936 3005-4620 401 µM -0.170562321187478 0.451094792125579 no 1877 0.43228396352175 2899 777207
SGTC_45 0kpi-0036 14.9 µM -0.17140118441124 0.450790085154811 no 1878 0.431954161767684 2827 2795021
SGTC_3256 9138902 49.47 µM -0.173826280609223 0.449909361871742 no 1879 0.431000994933361 2688 17228773
SGTC_2748 diazoxide 86.69 µM -0.173879375873243 0.449890081984252 no 1880 0.430980130691077 2798 3019 A potassium channel activatior.
SGTC_1085 doxorubicin 7.67 µM -0.174146642565486 0.449793034226131 no 1881 0.430875108863793 2801 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2588 indole-3-carbinol 100 µM -0.175181584362647 0.449417262760296 no 1882 0.430468477060103 2845 3712 Induces cell cycle arrest.
SGTC_1286 0929-0070 131 µM -0.175566961382014 0.449277349857156 no 1883 0.430317080061094 2837 1420408
SGTC_71 0417-1750 47.813 µM -0.175938350211572 0.449142521397808 no 1884 0.430171188073764 2920 6811472
SGTC_3207 9114163 49.47 µM -0.176742277123358 0.448850685077728 no 1885 0.429855415627666 2959 849233
SGTC_990 3985-0011 41.3 µM -0.177645816348487 0.448522721178711 no 1886 0.42950057026641 2797 5399565 YGL099W LSG1
SGTC_2935 9038016 29.96 µM -0.177654915599199 0.448519418539108 no 1887 0.429496997022965 2801 6463195
SGTC_2704 st078022 71.1 µM -0.177987646384081 0.448398653919281 no 1888 0.429366338794947 2861 54697681
SGTC_800 3448-7362 155 µM -0.179651923365929 0.447794676676181 no 1889 0.428712919414067 2789 15991913
SGTC_2344 7990960 76.95 µM -0.18017258361992 0.447605750375219 no 1890 0.428508540647379 2766 140813
SGTC_1297 1068-0111 14.1 µM -0.180192460128284 0.447598538238946 no 1891 0.428500738748528 2710 767057
SGTC_1142 3253-1408 9.78 µM -0.181895263779969 0.446980745192246 no 1892 0.427832460725936 2708 256655
SGTC_3024 9090631 49.47 µM -0.183882157159202 0.446260044460784 no 1893 0.427052951324294 2751 25236383
SGTC_310 1273-0058 1.06 µM -0.184729634836661 0.445952694920241 no 1894 0.426720550479039 2824 2734232
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.185236943573611 0.445768727892249 no 1895 0.426521596842638 2747 6708514
SGTC_889 0919-1524 82.7 µM -0.185338459134075 0.445731916372876 no 1896 0.426481787254469 2798 3905452
SGTC_3147 9097027 49.47 µM -0.186329781581253 0.445372468183922 no 1897 0.426093077036879 2768 25236841
SGTC_1390 3413-2614 145 µM -0.186711060111906 0.445234230579258 no 1898 0.425943591942177 2803 3421432
SGTC_2426 5582046 32.21 µM -0.191497982766415 0.443499240129388 no 1899 0.424067730407552 2885 2251934
SGTC_1178 0988-0033 191 µM -0.192087142420634 0.443285777011643 no 1900 0.423836973117429 2890 5392207
SGTC_2131 toluylene red 5.2905 µM -0.192600783218388 0.443099689157669 no 1901 0.423635815746777 2787 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2605 digitonin 300 nM -0.196218304660717 0.441789448515187 no 1902 0.422219650747151 2780 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2596 sinensetin 100 µM -0.197377135935139 0.441369861990055 no 1903 0.421766210275887 2817 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_395 anisomycin 6.25 µM -0.197698391563188 0.441253554240301 no 1904 0.421640524112397 2814 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1151 3909-8316 15.3 µM -0.198022723946525 0.441136137717831 no 1905 0.421513642314624 2848 800431
SGTC_925 2064-1272 59.6 µM -0.198918135945293 0.440812002827035 no 1906 0.42116339128493 2778 6815817
SGTC_1857 st056007 79.3 µM -0.200088434278847 0.440388420196661 no 1907 0.42070570928812 2835 619834
SGTC_524 r073-0010 27.8 µM -0.201098193809469 0.440022998442458 no 1908 0.420310897138896 2748 2772106
SGTC_745 0469-0705 296 µM -0.2015430078875 0.439862040919625 no 1909 0.420137001931854 2925 3486736
SGTC_752 1896-0090 130 µM -0.201559920107114 0.439855921370041 no 1910 0.420130390591663 2749 772567
SGTC_1817 st052116 64.4 µM -0.202716174211014 0.43943757434514 no 1911 0.419678440229106 2907 4361398
SGTC_3325 9138760 55.175 µM -0.202947224286034 0.439353985664548 no 1912 0.419588141302122 2802 43844959
SGTC_3048 9093155 49.47 µM -0.203107560978024 0.439295981072338 no 1913 0.419525481048452 2795 25236002
SGTC_235 0330-0087 5 mM -0.203273244779839 0.439236043439277 no 1914 0.419460733265534 2786 46494818 YHR062C RPP1
SGTC_229 benomyl 22.8748 µM -0.204061357545458 0.438950955523687 no 1915 0.419152775564141 2848 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.206416296659678 0.438099281042973 no 1916 0.418232871018738 2912 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2159 5658611 73.75 µM -0.20772603497996 0.437625731983839 no 1917 0.417721444045563 2778 793844
SGTC_2948 9070189 9.45 µM -0.208136174118955 0.437477460388006 no 1918 0.417561321368434 2922 6473636 YDL196W YDL196W
SGTC_1880 MG-132 525 µM -0.208155946302707 0.43747031266167 no 1919 0.417553602442979 2876 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_8 0354-0001 70 µM -0.209537955848292 0.436970761177922 no 1920 0.417014154236332 2775 4993152
SGTC_972 1319-0219 195 µM -0.210849711274433 0.436496697208262 no 1921 0.416502273217183 2851 23903702
SGTC_97 0535-0701 19.132 µM -0.212171549071722 0.436019081752765 no 1922 0.415986600991626 2796 2832013 YGL099W LSG1
SGTC_1157 4092-0394 27.6 µM -0.213127772971723 0.435673630516859 no 1923 0.415613651282712 2967 3659885
SGTC_1943 st076331 65.2 µM -0.213810212899984 0.43542711813189 no 1924 0.415347530187915 2874 24208415
SGTC_3201 9113999 49.47 µM -0.214731658452801 0.435094311460787 no 1925 0.414988269201478 2987 16649224
SGTC_1627 st003713 25.6 µM -0.216253234671009 0.434544851018336 no 1926 0.414395179924091 2865 16195070 YER133W GLC7
SGTC_2416 tofa 880 nM -0.216363628715797 0.434504991236257 no 1927 0.414352157434714 2809 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_914 3820-6779 408 µM -0.217772446986554 0.433996370319274 no 1928 0.413803206729366 2763 2893481
SGTC_598 3937-0236 20.2 µM -0.218611587504073 0.433693470108921 no 1929 0.413476312802616 2863 1379313
SGTC_550 4123-0385 25.7 µM -0.218722821566175 0.433653321444016 no 1930 0.413432985176768 2796 5731123
SGTC_1641 st009299 47.1 µM -0.218772303590217 0.433635461692279 no 1931 0.413413711395832 2804 4046054
SGTC_1217 1183-1422 255 µM -0.21878820697046 0.433629721648198 no 1932 0.413407516902363 2919 2849664
SGTC_2101 5377231 179.231 µM -0.218920725604497 0.433581891933294 no 1933 0.413355900675498 2923 2844213
SGTC_2145 5634607 200 µM -0.219045239897032 0.433536952097405 no 1934 0.413307403517337 2780 308662
SGTC_3241 9133421 49.47 µM -0.219186231947998 0.433486066128132 no 1935 0.413252490022506 2808 17018221
SGTC_449 xestospongin c 11.1929 µM -0.219368890079038 0.433420143937375 no 1936 0.413181350972655 2919 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1449 4112-4002 201 µM -0.219776361875514 0.433273092100017 no 1937 0.413022665019709 2823 2059539
SGTC_2157 5649910 96.377 µM -0.219851549343428 0.433245958825328 no 1938 0.412993385539222 2816 2858091
SGTC_197 4544-0043 41.561 µM -0.220471116475486 0.433022384550498 no 1939 0.412752132338969 2805 896523
SGTC_1701 st028638 40.4 µM -0.220973024002626 0.432841284117193 no 1940 0.412556718759195 2908 3490878
SGTC_1710 st031758 61.5 µM -0.221024268490189 0.432822794653656 no 1941 0.4125367683567 2959 5394341
SGTC_404 fumagillin 50 µM -0.221499373651949 0.432651379524703 no 1942 0.412351812120903 2838 12015870 A methionine aminopeptidase binder.
SGTC_3141 9094609 49.47 µM -0.22296094627584 0.432124132378069 no 1943 0.411782950882675 2765 25236309 YDL196W YDL196W
SGTC_1043 0916-0009 19.3 µM -0.222992807891375 0.43211263997385 no 1944 0.411770552027628 2982 3101130
SGTC_2185 6113692 200 µM -0.224620349539337 0.431525666438622 no 1945 0.411137316373976 2925 874150
SGTC_961 1252-1571 372 µM -0.225021074314254 0.431381168033093 no 1946 0.410981439858083 2965 6813498
SGTC_2913 7966556 36.57 µM -0.226133350324289 0.430980137663057 no 1947 0.410548853260054 2881 2976516
SGTC_2286 7945697 125 µM -0.226136496203053 0.43097900351929 no 1948 0.41054762991833 2871 1245733
SGTC_2979 9012552 45.46 µM -0.226447327622655 0.430866946218179 no 1949 0.410426760816819 2906 17100905
SGTC_3099 9120367 49.47 µM -0.228798339450677 0.430019567852421 no 1950 0.409512828743336 2794 24824940
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.228945003891839 0.429966716027798 no 1951 0.40945583066185 2900 6708739 YPR165W RHO1
SGTC_316 k060-0003 58.6 µM -0.230020170846104 0.429579308513838 no 1952 0.409038047925872 2953 6152314
SGTC_3332 9141069 11.198 µM -0.231256535870402 0.429133901444539 no 1953 0.408557755421222 2795 17332883
SGTC_3107 9121808 49.47 µM -0.233046330179368 0.428489278506405 no 1954 0.407862714879256 2806 662681
SGTC_2566 crystal violet carbinol 226 nM -0.233103696049899 0.428468620419796 no 1955 0.407840442461917 2994 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2279 7948423 32.93 µM -0.234464917423142 0.427978487124703 no 1956 0.407312032995868 3024 1247112
SGTC_2006 4011487 200 µM -0.235078947180438 0.427757430506334 no 1957 0.407073729295189 2964 45595294
SGTC_2058 5236698 133 µM -0.236951092937922 0.427083580269459 no 1958 0.406347365997316 2852 766665
SGTC_1489 4065-0444 182 µM -0.237295421826678 0.426959667452322 no 1959 0.406213806771955 2926 2877968
SGTC_2965 9082772 38.63 µM -0.238174304995112 0.42664341856267 no 1960 0.405872952688326 2990 16459634
SGTC_3225 9130819 49.47 µM -0.240970173030967 0.42563769477311 no 1961 0.404789116952072 2959 4547121
SGTC_2841 9004761 38.96 µM -0.241307393070765 0.425516423240334 no 1962 0.404658440666778 2846 2991039
SGTC_763 3453-1109 128 µM -0.241787700979294 0.425343706419649 no 1963 0.404472334700371 2972 1560353
SGTC_148 3253-0744 288.01 µM -0.243171374219568 0.424846223201268 no 1964 0.403936320722489 2810 6893655
SGTC_1997 st073024 93.8 µM -0.24358830313575 0.424696344806111 no 1965 0.403774844108118 2959 686268
SGTC_1061 3448-9325 110 µM -0.243940946106995 0.424569584540958 no 1966 0.403638278246901 2816 723482
SGTC_279 1273-0055 2.93 µM -0.244279012172343 0.424448071381823 no 1967 0.403507368522707 2901 2847562
SGTC_1848 st056003 16.4 µM -0.245652037721516 0.423954630308544 no 1968 0.402975801467175 2842 146492
SGTC_974 1326-0144 138 µM -0.245714770720552 0.423932088021054 no 1969 0.402951518651928 2850 5411856
SGTC_1 0258-0098 57.368 µM -0.24591102443628 0.423861568407804 no 1970 0.402875554787048 2898 6790032 YDR047W HEM12
SGTC_1342 1486-1464 234 µM -0.249209976665857 0.422676526536245 no 1971 0.401599181288853 2839 3253938
SGTC_2805 7950783 58.44 µM -0.251428717212278 0.421879908489972 no 1972 0.400741333759267 2978 1178958 YDL195W SEC31
SGTC_3279 9140807 49.47 µM -0.251543163635662 0.421838826210578 no 1973 0.400697097461319 2813 45595718
SGTC_640 3381-0960 37.1 µM -0.252474892376136 0.421504399737483 no 1974 0.400337009305354 2908 1745025
SGTC_986 1493-0483 84 µM -0.254308995327823 0.420846248670272 no 1975 0.399628425467706 2943 40079
SGTC_205 1486-1330 71.903 µM -0.254807594105455 0.420667369217097 no 1976 0.399435854795655 2845 4118834
SGTC_1904 st060225 78 µM -0.256620173226827 0.420017218769124 no 1977 0.398736000207226 2860 66595
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.256950545493222 0.419898741647833 no 1978 0.398608475235665 2876 115019
SGTC_1839 st053978 48 µM -0.257927200574007 0.419548538991926 no 1979 0.39823154595191 2942 3788398
SGTC_3176 9106582 49.47 µM -0.257993884180641 0.419524630336378 no 1980 0.398205813606135 2930 17018027
SGTC_15 0266-0086 27.098 µM -0.258355448615545 0.419395000658198 no 1981 0.398066298253295 2943 1712902 YIL048W NEO1
SGTC_3273 9137859 49.47 µM -0.259154597328006 0.419108517386343 no 1982 0.39775798034739 2898 2377234
SGTC_2645 abamectin 100 µM -0.259525468366569 0.418975580034586 no 1983 0.397614917041281 2990 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2011 4012611 177 µM -0.259716382113402 0.418907151313934 no 1984 0.397541277532062 2867 2049887
SGTC_1149 3909-7961 23.3 µM -0.260367697342329 0.418673720553958 no 1985 0.397290078830225 2881 735261
SGTC_2661 dactinomycin 12.96 µM -0.261258998985024 0.418354325308954 no 1986 0.396946391421454 2895 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1369 1866-0067 208 µM -0.2634521982263 0.417568628601937 no 1987 0.396101031357577 3009 3531355
SGTC_2525 harmine 47.85 µM -0.263497072857957 0.417552556035159 no 1988 0.396083739691367 2915 5280953 A monoamine oxidase inhibitor
SGTC_2753 fluvastatin 17.09 µM -0.266832050543546 0.416358467734781 no 1989 0.394799237938834 2960 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_169 k015-0017 16.025 µM -0.267184329219992 0.416232379265408 no 1990 0.394663620586812 3093 1840002
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.267956058687484 0.415956190058992 no 1991 0.394366571144521 2980 616764
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.268071826024153 0.415914762421408 no 1992 0.394322015974893 2870 688803
SGTC_2874 9043904 71.43 µM -0.268599977438576 0.415725773948427 no 1993 0.394118764828186 2947 4463428
SGTC_1590 st077108 57.8 µM -0.271264619832023 0.414772582781482 no 1994 0.393093757940899 2983 5489485
SGTC_2497 7-hydroxyflavone 100 µM -0.271465060751085 0.414700901624722 no 1995 0.393016684282878 3049 5281894
SGTC_1365 1672-3266 55.4 µM -0.274495631544559 0.413617464261884 no 1996 0.39185188013392 2997 6415873
SGTC_2385 9074692 200 µM -0.274674429334419 0.413553564016036 no 1997 0.391783189112521 2917 17046906
SGTC_1072 oxiconazole 14.9 nM -0.278748941375647 0.412098004664538 no 1998 0.390218750345021 2898 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1871 st057448 67.3 µM -0.28026815917529 0.411555594711235 no 1999 0.389635888760282 3098 691747
SGTC_1026 k007-1105 30.6 µM -0.282038391709283 0.410923777600624 no 2000 0.388957036203437 2903 7066794
SGTC_2820 7989630 71.43 µM -0.282363354383072 0.410807819594467 no 2001 0.388832455575253 2963 2984098
SGTC_2909 7941780 10.49 µM -0.284928982545337 0.409892588545431 no 2002 0.387849275527039 3044 1243215
SGTC_1694 st024011 44.9 µM -0.28522688206795 0.409786351187305 no 2003 0.387735163232102 2962 2787533
SGTC_2785 7756463 72.73 µM -0.286003913201394 0.409509276406772 no 2004 0.387437562196037 2904 2201551
SGTC_2167 5876490 200 µM -0.28641326600082 0.409363327015001 no 2005 0.387280807653827 3126 686534
SGTC_2110 5483698 200 µM -0.286523557610745 0.40932400612998 no 2006 0.387238576539813 2970 2848765 YHR062C RPP1
SGTC_846 0335-0850 148 µM -0.286777163717305 0.409233594585267 no 2007 0.387141474774891 2992 6819598
SGTC_2281 7943571 200 µM -0.286921137623661 0.409182269486429 no 2008 0.38708635258664 3117 1244024
SGTC_1075 aripiprazole 15.2 µM -0.288182265117017 0.408732758179178 no 2009 0.386603611792579 2900 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1173 0443-0020 122 µM -0.288700818646505 0.408547961795268 no 2010 0.386405168087864 2918 5331295
SGTC_2155 5570423 76 µM -0.288974383352337 0.408450480014588 no 2011 0.386300490392403 2936 797402
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.289637521244505 0.408214201624027 no 2012 0.386046779491417 3093 23847180
SGTC_591 4299-0174 154 µM -0.290447245256363 0.407925739332935 no 2013 0.38573705207362 2970 5509088
SGTC_3310 9130229 44.1445 µM -0.290544830100528 0.407890978326098 no 2014 0.385699729822684 3070 7761258
SGTC_1879 gemcitabine 100 µM -0.292429447179494 0.407219795426011 no 2015 0.384979148057105 2936 60750 A nucleoside analog which inhibits DNA replication.
SGTC_47 0149-0135 24.25 µM -0.292553555716819 0.407175605252467 no 2016 0.384931709169272 2902 5239155
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.294537471499629 0.406469371560466 no 2017 0.384173617229082 3055 16725076
SGTC_779 1360-0071 233 µM -0.294808159427703 0.406373035688852 no 2018 0.384070216498222 3118 7566
SGTC_3133 9127736 49.47 µM -0.295419879810407 0.406155349721744 no 2019 0.383836574365499 3083 27243420
SGTC_3250 9135583 49.47 µM -0.295903430989803 0.405983294393576 no 2020 0.383651915396727 3067 7699353
SGTC_1897 st060201 15 µM -0.296212245882771 0.405873422560082 no 2021 0.383533998703347 2949 611878
SGTC_1261 0712-0010 12.7 µM -0.297950550486617 0.405255097702803 no 2022 0.382870452673921 3116 2840123
SGTC_1851 st056236 18.9 µM -0.297951766982792 0.405254665070779 no 2023 0.382869988432817 3107 5393171
SGTC_1564 D-Arginine 115 µM -0.300199281701249 0.404455562107019 no 2024 0.382012576470724 2968 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_611 3453-1652 23.7 µM -0.300350924303357 0.404401659950527 no 2025 0.381954746605162 3044 1560575
SGTC_1082 camptothecin 424.86 nM -0.300965934089939 0.404183070116185 no 2026 0.381720235747591 2789 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3243 9134147 49.47 µM -0.303090129225818 0.403428308608702 no 2027 0.38091058815671 2990 24282180
SGTC_269 exalamide 29 µM -0.303760260699624 0.403190274336324 no 2028 0.380655272168357 2948 3316 A derivative of salicylamide.
SGTC_1744 st037937 38.9 µM -0.303791721329343 0.403179100233686 no 2029 0.380643287137358 3134 1016152
SGTC_1459 k035-0031 35.7 µM -0.305148943202408 0.402697121175182 no 2030 0.380126358178549 2916 3877128 YMR208W ERG12
SGTC_204 PMA1.184 62.41 µM -0.305746646727173 0.402484910477997 no 2031 0.379898776971536 2953 2252213 YGL008C PMA1
SGTC_2218 6965428 192.983 µM -0.306204113255491 0.40232250940972 no 2032 0.379724620403276 3025 675684
SGTC_3067 9117431 49.47 µM -0.306971398309852 0.402050160322346 no 2033 0.379432571344009 2973 17150885
SGTC_1834 st055981 52.8 µM -0.30881286266198 0.401396723776472 no 2034 0.378731942041668 3100 471719 YDL150W RPC53
SGTC_3159 9100096 49.47 µM -0.31063580281131 0.400750131956091 no 2035 0.378038753031642 2855 25236875
SGTC_3115 9123671 49.47 µM -0.311094816053043 0.400587364002024 no 2036 0.377864270977057 3019 3286988
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.311692063635988 0.400375603435364 no 2037 0.377637280002869 2957 165521
SGTC_119 0121-0043 24.815 µM -0.312774050019312 0.399992048119024 no 2038 0.377226165999504 2973 1092378
SGTC_3284 9108171 64.8615 µM -0.315639101215374 0.398976877722123 no 2039 0.376138227640015 3051 8687505
SGTC_642 0335-0876 158 µM -0.317030158709874 0.398484231730611 no 2040 0.375610359182347 2965 6812350
SGTC_2691 st077356 60.2 µM -0.317179711108456 0.398431277043316 no 2041 0.375553621957415 3133 2839272
SGTC_1875 nocodazole 6 µM -0.318336679283584 0.39802167194016 no 2042 0.375114782124244 3067 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2018 5133068 143 µM -0.318390542793348 0.398002605205388 no 2043 0.375094355543669 2914 785362
SGTC_2940 9060638 45.86 µM -0.318494446138631 0.397965825937422 no 2044 0.375054953418625 3060 4027022
SGTC_2355 9061122 103.12 µM -0.319972011804567 0.397442901748681 no 2045 0.374494773704625 3084 5302957
SGTC_109 0132-0036 33.701 µM -0.320965249623556 0.397091489178569 no 2046 0.37411836275823 2906 67274 A color developer.
SGTC_3020 9089140 49.47 µM -0.321058726141671 0.397058421009447 no 2047 0.374082943794337 3056 17217859
SGTC_596 1155-0152 116 µM -0.321305204081356 0.396971230743863 no 2048 0.373989556525082 2998 280313
SGTC_822 1487-0950 154 µM -0.321948205621088 0.396743796606057 no 2049 0.37374596647211 3129 1958375
SGTC_2363 9053361 176 µM -0.322443909264161 0.396568486733662 no 2050 0.373558212102814 3144 6469797 YMR079W SEC14
SGTC_268 camptothecin 39.6153 µM -0.322726848112696 0.39646843233745 no 2051 0.37345105868789 3059 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1635 st007035 42.4 µM -0.322780540201904 0.396449446214138 no 2052 0.373430725749147 3043 3716403
SGTC_2278 7948257 134.34 µM -0.325775143423545 0.395390911016762 no 2053 0.372297243176958 3119 1247028
SGTC_2922 7999257 32.47 µM -0.325882602326379 0.39535294063162 no 2054 0.37225658956389 2979 2988377
SGTC_3056 9094900 49.47 µM -0.326765307975431 0.395041076011748 no 2055 0.371922700241596 3013 25236784
SGTC_416 estradiol valerate 100 µM -0.32744258818535 0.394801834864915 no 2056 0.371666579740787 3050 13791 A steroid.
SGTC_771 0250-0039 27.3 µM -0.327913255491376 0.394635600612661 no 2057 0.371488625483431 2995 3005115
SGTC_1278 0874-0585 172 µM -0.328907530296448 0.394284497344057 no 2058 0.37111279117798 3060 766306
SGTC_2735 sertaconazole 140 nM -0.329303537170613 0.394144681323613 no 2059 0.370963135405778 3017 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1692 fluoroquinolonic acid 71 µM -0.329539167340274 0.394061495116502 no 2060 0.370874097182796 3093 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_902 1120-0002 2.07 µM -0.329634394507398 0.394027877758397 no 2061 0.370838115391491 2976 3280475
SGTC_2717 st081029 62.2815 µM -0.333752028074495 0.392575017762343 no 2062 0.369283342839241 3105 5292846
SGTC_1663 st014140 55.4 µM -0.333808383416041 0.392555143753494 no 2063 0.369262078448403 3023 4207120
SGTC_3121 9125696 49.47 µM -0.333818572111844 0.39255155068601 no 2064 0.369258234021281 3007 1235365
SGTC_2480 5767542 37.17 µM -0.334260085418952 0.392395858783205 no 2065 0.369091653553398 3019 2867358
SGTC_3051 9093778 49.47 µM -0.337509205701538 0.39125064486945 no 2066 0.36786653685138 3050 17217378
SGTC_456 gingerol 170 µM -0.339049575896433 0.390708040840724 no 2067 0.367286191732611 3193 442793 A herb.
SGTC_2984 9022109 38.96 µM -0.341158319414078 0.389965569276234 no 2068 0.366492199629759 3124 6459207
SGTC_569 4130-2812 160 µM -0.341190478554684 0.389954249402217 no 2069 0.366480095360727 3027 743552
SGTC_1246 0422-0085 105 µM -0.341218152512722 0.389944508367163 no 2070 0.366469679360552 3153 264295
SGTC_3230 9131665 49.47 µM -0.341450766144769 0.389862632767126 no 2071 0.366382131492795 2991 15943720
SGTC_691 1548-0686 185 µM -0.341517193647659 0.389839252439025 no 2072 0.366357131713834 3042 46495133
SGTC_1559 coumarin 343 70.1 µM -0.341618587089897 0.389803566002071 no 2073 0.366318973708603 3166 108770 A hepatotoxic, DNA x-linker.
SGTC_1066 ketoconazole 628 nM -0.341933205865813 0.389692838689036 no 2074 0.366200579743332 3155 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1994 st072947 40.9 µM -0.341951385295403 0.389686440872083 no 2075 0.366193739044378 3119 5286565 YDL195W SEC31
SGTC_555 4296-0685 37 µM -0.342762175417903 0.389401133033318 no 2076 0.365888691821974 3053 2908540 YHR072W ERG7
SGTC_677 0929-0063 136 µM -0.343247434768886 0.389230404279831 no 2077 0.365706161044538 3048 1539583
SGTC_2512 diallyl trisulfide 49.23 µM -0.343737460274167 0.389058020348634 no 2078 0.365521868323528 3074 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3265 9137266 49.47 µM -0.344081524544869 0.388936996528814 no 2079 0.365392488419825 3092 17224265
SGTC_511 blebbistatin 171 µM -0.351059058723244 0.386485005416489 no 2080 0.362772020979362 3169 3476986 A myosin inhibitor.
SGTC_57 miconazole 162.5 nM -0.351347086144812 0.386383885645499 no 2081 0.362663987048319 3060 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_223 busulfan 5 mM -0.351431038565697 0.386354413342681 no 2082 0.362632500054992 3100 2478 A DNA alkylator.
SGTC_1647 st011722 22.4 µM -0.351733052979196 0.386248393708262 no 2083 0.362519234937974 3162 2854783
SGTC_3184 9108758 49.47 µM -0.354375199155889 0.385321253346224 no 2084 0.361528859188731 2970 902885
SGTC_2147 5545932 89.7195 µM -0.355964734396006 0.384763793876229 no 2085 0.360933487752814 3067 797404
SGTC_545 4218-0007 221 µM -0.356016216904092 0.384745742629728 no 2086 0.360914210246148 3154 2840508
SGTC_2488 5268135 45.7 µM -0.356639770475526 0.384527126681996 no 2087 0.360680750115687 3163 1270356 YLR208W SEC13
SGTC_1281 0884-0031 11.8 µM -0.357125526732012 0.384356847485069 no 2088 0.360498917637441 3060 1548255
SGTC_200 k038-0079 37.545 µM -0.357206113417156 0.384328600420804 no 2089 0.36046875478263 3020 3436683
SGTC_2810 7959871 45.46 µM -0.358789176319719 0.383773833492143 no 2090 0.359876405174835 3126 2974535
SGTC_1231 0242-0792 125 µM -0.359451380847868 0.383541841793476 no 2091 0.359628721549674 3020 3707635
SGTC_1444 4112-3581 28 µM -0.360779359452348 0.383076733737656 no 2092 0.359132196923521 3055 2877249
SGTC_2367 9070478 135.38 µM -0.361776308249654 0.382727675468856 no 2093 0.358759598954975 2994 572802
SGTC_222 nsc-310342 10.666 µM -0.363225186263387 0.382220554613739 no 2094 0.35821833733536 3141 432556
SGTC_1412 3909-8563 178 µM -0.36357173556604 0.382099289015498 no 2095 0.358088918059044 3158 23767530
SGTC_372 0155-0182 15.9 µM -0.365405498886226 0.381457805684652 no 2096 0.357404368555678 3016 771486
SGTC_2049 5262831 67.185 µM -0.365632891659457 0.381378282258575 no 2097 0.357319514047222 3117 763417
SGTC_3132 9126706 49.47 µM -0.366123524467764 0.381206716024541 no 2098 0.357136452205261 3235 850858
SGTC_481 bay k-8644 50 µM -0.366846979600182 0.380953778247961 no 2099 0.356866581153874 3059 2303 A calcium channel antagonist.
SGTC_2851 9015922 71.43 µM -0.367786800150791 0.380625269744227 no 2100 0.356516106096977 3217 2996893
SGTC_433 pimozide 108 µM -0.368067423739934 0.38052719616469 no 2101 0.356411480261415 3001 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1816 st051957 91.6 µM -0.368093002996009 0.380518256994297 no 2102 0.356401943998712 3070 674121
SGTC_3041 9091929 49.47 µM -0.369479907682962 0.380033671701755 no 2103 0.355885023353506 3241 25236887
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.37008198032644 0.379823365737311 no 2104 0.355660704029853 3146 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3148 9097893 49.47 µM -0.37031242153577 0.379742881262017 no 2105 0.355574859810238 3038 17174100
SGTC_1439 4092-1168 46 µM -0.370364576625649 0.379724666167202 no 2106 0.355555431953661 3121 2886240
SGTC_476 mead acid 10 µM -0.37037490972526 0.37972105737777 no 2107 0.355551582901635 3044 5312531 An omega 9 fatty acid.
SGTC_2434 5670830 169.91 µM -0.371767188223558 0.37923490617803 no 2108 0.355033097730895 3149 1549830
SGTC_331 k048-0133 24.5 µM -0.373031940181226 0.378793449734771 no 2109 0.354562336044295 3055 6813582
SGTC_848 0368-0089 85.6 µM -0.376625267072701 0.377540078186536 no 2110 0.353226053888304 3177 762535
SGTC_834 0312-0008 75.7 µM -0.376802271526987 0.377478371283253 no 2111 0.353160276263535 3066 6385573 YIL048W NEO1
SGTC_2991 9074669 71.4286 µM -0.376853684919123 0.377460448245722 no 2112 0.353141171064667 3244 17333109
SGTC_2495 cafestol 54.53 µM -0.376955397857548 0.377424991241953 no 2113 0.353103375662244 3235 16667697 An anti-infammatory.
SGTC_1540 guanosine 70.6 µM -0.378774528807242 0.376791019195148 no 2114 0.352427651769984 3107 6802 Guanosine is a purine nucleoside
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.378931946509295 0.37673617428898 no 2115 0.352369200151762 3048 442882
SGTC_2231 micatex 6.853 µM -0.380640893038579 0.376140931344071 no 2116 0.35173486661759 3129 20737 An antifungal of unknown mechanism.
SGTC_257 daunorubicin 18.5 µM -0.380970187127015 0.376026268761904 no 2117 0.351612685285412 3169 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1614 st002383 48.6 µM -0.383014207878715 0.375314771121591 no 2118 0.350854614775427 3163 1947235
SGTC_3282 9108498 15.4605 µM -0.383803843587783 0.375040022360203 no 2119 0.350561919540024 3162 16459645
SGTC_2499 avocadenofuran 51.48 µM -0.383936675392893 0.374993810597428 no 2120 0.350512691322659 3038 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1108 betulinic acid 729.144 nM -0.384292132282575 0.374870157103369 no 2121 0.350380969341265 3113 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3294 9122953 26.2835 µM -0.384572105566985 0.374772771295589 no 2122 0.350277232053631 3069 16459826
SGTC_1430 4049-0248 69.1 µM -0.38461278288356 0.37475862277648 no 2123 0.350262160992895 3183 22774488
SGTC_2078 5212016 200 µM -0.385567678686859 0.374426536219202 no 2124 0.349908437179829 3139 1899708
SGTC_1087 pterostilbene 9.05 µM -0.385770802248114 0.374355907422809 no 2125 0.349833210530029 3206 5281727 Similar to reservatol, lowers cholesterol.
SGTC_232 clozapine 119 µM -0.386427540528483 0.374127579546845 no 2126 0.349590028380289 3114 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_6 0844-0013 19.835 µM -0.387065777044434 0.373905726469938 no 2127 0.349353756330933 3182 1584900
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.387608516741036 0.373717101251786 no 2128 0.34915288265178 3143 5379071
SGTC_536 3852-0578 10.6 µM -0.38911959319465 0.373192097113152 no 2129 0.34859384008104 3236 2869208
SGTC_3252 9135871 49.47 µM -0.389133158140763 0.373187385210992 no 2130 0.348588823037759 3227 17682838
SGTC_1357 1503-1303 39.5 µM -0.390172131431873 0.372826545195805 no 2131 0.34820463384479 3114 292895
SGTC_1007 4101-0031 70 µM -0.390241880571647 0.372802325003891 no 2132 0.348178847739287 3223 1146276
SGTC_1380 2291-0730 164 µM -0.390932395549734 0.372562572771512 no 2133 0.347923603737343 3164 2999191
SGTC_3073 9114972 49.47 µM -0.391451521584013 0.372382360633282 no 2134 0.347731757812066 3180 41905075
SGTC_3004 9076122 71.4286 µM -0.391788688384931 0.372265329743052 no 2135 0.34760717681595 3227 44782551
SGTC_842 0271-0008 11.1 µM -0.39336828587859 0.371717207324586 no 2136 0.347023744885676 3224 1221709
SGTC_801 0866-0028 10.1 µM -0.39418476562244 0.371433989611381 no 2137 0.346722316165527 3054 6849771
SGTC_2552 juarezic acid 87.02 µM -0.394268579665113 0.371404920417711 no 2138 0.34669137910921 3075 1549512
SGTC_460 trequinsin 123 µM -0.396625043437658 0.370587929721556 no 2139 0.345821991075987 3186 5537 A vasodilator.
SGTC_357 1325-0123 420 µM -0.398493471462142 0.369940556350114 no 2140 0.345133234856566 3214 1098503
SGTC_2656 pseudo-anisatin 100 µM -0.399192009596066 0.369698621201308 no 2141 0.344875865186814 3120 6708809 A neurotoxin.
SGTC_1143 3454-2408 5.08 µM -0.399601836009761 0.369556703894701 no 2142 0.344724901971679 3183 X1143
SGTC_1902 st060212 70.5 µM -0.399727036136878 0.369513352338059 no 2143 0.344678788316705 3215 688944
SGTC_3002 9075603 71.4286 µM -0.400807187836602 0.369139410021822 no 2144 0.344281043228392 3148 20105405
SGTC_273 hydroxyurea 18.1 mM -0.402760255293863 0.368463583802665 no 2145 0.343562301039325 3096 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3309 9129340 25.759 µM -0.404265646220841 0.367942945966006 no 2146 0.343008692442777 3145 17158987
SGTC_2073 5212005 126 µM -0.404403331075792 0.367895339896705 no 2147 0.342958075533767 3129 691789
SGTC_1450 4112-4260 37.6 µM -0.405237337357277 0.367607016348496 no 2148 0.342651531127964 3252 1633175
SGTC_1415 3966-0071 78.1 µM -0.405261989972382 0.367598494849926 no 2149 0.342642471475082 3190 2893185
SGTC_2796 7949634 45.45 µM -0.405430960313944 0.36754008979804 no 2150 0.342580378566484 3085 2971588
SGTC_777 1315-0167 517 µM -0.405738729526689 0.36743371641683 no 2151 0.342467291036203 3184 4221767
SGTC_2026 5148700 152 µM -0.406028945277864 0.367333419305296 no 2152 0.342360666331633 3093 79838
SGTC_2183 6420625 130.508 µM -0.406383799745628 0.367210795676056 no 2153 0.342230310561046 3190 2897619
SGTC_2428 5615643 7.78 µM -0.40646118341647 0.367184056746969 no 2154 0.342201886169521 3206 2253075
SGTC_1945 st075991 56.6 µM -0.406605290246171 0.36713426420795 no 2155 0.342148955563928 3143 1084980
SGTC_3203 9113543 49.47 µM -0.406990645414105 0.367001125271635 no 2156 0.342007429401785 3243 17018012
SGTC_508 roscovitine 141 µM -0.407476476898491 0.366833294894845 no 2157 0.341829033776883 3131 160355 A CDKinase inhibitor.
SGTC_2391 6285546 200 µM -0.409345978408534 0.366187713681441 no 2158 0.341142889046873 3099 846083
SGTC_1123 mangostin 811.285 nM -0.410232407684606 0.365881741768979 no 2159 0.340817734957314 3168 5281650 An antioxidant.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.410652325710343 0.365736826944703 no 2160 0.340663744673561 3144 688669
SGTC_2374 9071832 200 µM -0.411030660071014 0.365606279158546 no 2161 0.340525026485324 3231 17381698
SGTC_947 3447-0010 211 µM -0.412334674175855 0.365156436341165 no 2162 0.340047068583187 3201 748350
SGTC_2650 prasterone 100 µM -0.412563345952914 0.365077571050015 no 2163 0.339963280393796 3197 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_533 1222-0222 6.71 µM -0.412648784843373 0.365048105987799 no 2164 0.339931976547562 3290 3982874
SGTC_27 0485-0001 32.618 µM -0.412751807114475 0.365012578055799 no 2165 0.339894231816614 3165 2054479
SGTC_2003 4023581 200 µM -0.413449240793736 0.36477209379061 no 2166 0.339638752142216 3248 16641307
SGTC_1682 st012968 530 nM -0.413881844495505 0.364622953094634 no 2167 0.339480320386031 3116 24207270
SGTC_931 2812-0076 566 µM -0.415001016125817 0.364237212310208 no 2168 0.339070579633487 3107 3450959
SGTC_3169 9102970 49.47 µM -0.415862435440425 0.363940403681309 no 2169 0.338755334330145 3228 17027839
SGTC_120 rhodamine 6G 52.259 µM -0.416314790112049 0.363784574079631 no 2170 0.338589835663745 3086 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1676 st018489 23.4 µM -0.416800962352174 0.363617119934766 no 2171 0.338411999234463 3133 3696235
SGTC_2890 9046729 58.44 µM -0.416908475154121 0.363580092409845 no 2172 0.338372677104394 3115 903329
SGTC_1218 1348-1416 30.7 µM -0.416928446433417 0.363573214420051 no 2173 0.338365372928889 3131 6787668
SGTC_1360 1598-0022 39.8 µM -0.417108000537356 0.363511379029766 no 2174 0.33829970662316 3234 761525
SGTC_3223 9129970 49.47 µM -0.418051184504154 0.363186620888229 no 2175 0.337954847350496 3091 17248386
SGTC_1791 st048313 56.1 µM -0.420167751575671 0.362458200420198 no 2176 0.337181455618149 3240 1204976
SGTC_590 k048-0076 22.4 µM -0.420274547575988 0.362421459545793 no 2177 0.337142450649676 3248 6832814
SGTC_1300 1094-0077 113 µM -0.420451216678221 0.362360683110619 no 2178 0.337077929859938 3153 5532636
SGTC_427 1354-0053 47.3 µM -0.42090923830652 0.362203133959033 no 2179 0.336910679485289 3322 6813657
SGTC_1383 3049-0032 20.7 µM -0.420969932143322 0.362182258393374 no 2180 0.336888519048841 3273 712864
SGTC_2951 9072950 58.06 µM -0.421817400603057 0.361890815572663 no 2181 0.336579151900449 3227 16488155
SGTC_3179 9107801 49.47 µM -0.422546760326733 0.36164005422997 no 2182 0.336312988700986 3147 4818259
SGTC_2415 st077333 57.7 µM -0.4259514423168 0.360470277184028 no 2183 0.335071614539213 3371 2766255
SGTC_1027 k015-0025 8.67 µM -0.426052471769824 0.360435585470426 no 2184 0.335034805821144 3116 3598955
SGTC_34 0469-0683 81.75 µM -0.427414432264062 0.359968024753788 no 2185 0.334538748659847 3219 3690923
SGTC_767 0929-0023 86 µM -0.428637352486496 0.359548374958144 no 2186 0.334093579103033 3261 1204563
SGTC_810 3825-7150 143 µM -0.428941277089396 0.359444108306588 no 2187 0.333982980110572 3319 22330411 YGL099W LSG1
SGTC_710 3448-4187 58 µM -0.43222993761441 0.358316546485074 no 2188 0.332787151355738 3206 3946412
SGTC_1809 st050081 57.6 µM -0.43246193373733 0.358237049968203 no 2189 0.332702856518459 3313 5036894
SGTC_1065 prochlorperazine maleate 2.48 µM -0.432865788514152 0.358098678488275 no 2190 0.332556137722375 3254 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1684 st024538 14.6195 µM -0.433689827780357 0.357816398359679 no 2191 0.33225684718568 3168 6732859
SGTC_1458 k015-0034 6.33 µM -0.434337372176317 0.357594632258231 no 2192 0.332021734501459 3216 3598957
SGTC_2545 solidagenone 89.61 µM -0.434729497068781 0.357460363657766 no 2193 0.331879392560056 3097 6708572 An anti ulcer agent
SGTC_537 1334-0398 209 µM -0.43660974618344 0.356816787583656 no 2194 0.331197196637755 3294 5846986
SGTC_1283 0922-0125 16.4 µM -0.436735034668296 0.356773918002901 no 2195 0.331151759079606 3232 3360884
SGTC_2146 5545642 200 µM -0.437074281897648 0.356657847889251 no 2196 0.331028738979883 3253 825326
SGTC_1572 epiandrosterone 68.9 µM -0.43870055330134 0.356101619552223 no 2197 0.330439263058331 3169 441302 A steroid.
SGTC_770 0389-1121 67.2 µM -0.439111104434221 0.355961248422796 no 2198 0.330290516667413 3338 6753108
SGTC_1612 st002233 45.4 µM -0.439180954779095 0.355937367903762 no 2199 0.330265211923818 3266 1035021
SGTC_153 4077-0274 519.67 µM -0.439285162660831 0.355901742239774 no 2200 0.330227461889175 3438 3121976
SGTC_1158 4092-0494 91.8 µM -0.440801757960589 0.35538340467924 no 2201 0.329678260373816 3308 1148199
SGTC_850 0388-0143 75.9 µM -0.442240277742808 0.354891998613031 no 2202 0.329157671340092 3182 67273
SGTC_568 1193-0097 7.48 µM -0.442521638361011 0.354795912507706 no 2203 0.32905588782126 3236 3646150
SGTC_1731 st035964 63 µM -0.444117906243924 0.354250953784864 no 2204 0.32847867053115 3179 6739575
SGTC_1053 3366-3204 134 µM -0.44573694450433 0.353698526073363 no 2205 0.327893637237525 3202 3632071 YPR165W RHO1
SGTC_1911 st060208 74.3 µM -0.447187789044861 0.353203748856962 no 2206 0.327369738623086 3264 688783
SGTC_5 0352-0601 109.883 µM -0.447512736880834 0.353092966827319 no 2207 0.327252446805241 3233 762456
SGTC_1909 st060837 51.5 µM -0.448558416911897 0.352736555509466 no 2208 0.326875118293673 3194 678937
SGTC_747 3448-8087 38.7 µM -0.448690264777196 0.352691625431015 no 2209 0.326827554193012 3212 5168703
SGTC_2341 7987486 176.74 µM -0.449396350188214 0.352451046177771 no 2210 0.326572881869456 3329 1258686
SGTC_499 genistein 192 µM -0.455519814869081 0.350367127785768 no 2211 0.324367657790793 3283 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2663 amphotericin b 100 µM -0.456466749737355 0.350045269724363 no 2212 0.324027187859436 3278 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2104 5389443 200 µM -0.458086388540732 0.34949501295208 no 2213 0.323445188764583 3367 2244536
SGTC_3257 9139206 32.98 µM -0.45845628479977 0.349369388539811 no 2214 0.323312331183092 3295 4910041
SGTC_2305 7443522 69.23 µM -0.458969058293647 0.349195267357524 no 2215 0.323128192899631 3229 5415886
SGTC_2623 humulene 100 µM -0.45956952684235 0.348991408136746 no 2216 0.322912618179551 3281 6187145 An anti-inflammatory.
SGTC_2728 chlorpromazine 9.18 µM -0.460100188610953 0.34881128460421 no 2217 0.322722154359216 3226 2726 A thorazine and dopamine antagonist.
SGTC_829 1635-0120 117 µM -0.460565898561291 0.348653235858522 no 2218 0.322555041193769 3330 285054
SGTC_2938 9059746 27.26 µM -0.460823415252825 0.348565853273695 no 2219 0.322462650503337 3284 6471769
SGTC_354 2783-3500 4.88 µM -0.464668789682684 0.347261968682593 no 2220 0.321084331030015 3209 6740761
SGTC_820 1582-0060 59.9 µM -0.466077168548134 0.346784868348089 no 2221 0.320580132560993 3227 3848840
SGTC_1968 st069590 43.6 µM -0.467639567028079 0.34625587670898 no 2222 0.320021182336064 3297 6384066
SGTC_562 3772-2733 112 µM -0.468278632554637 0.34603959037738 no 2223 0.319792673337962 3327 2876874 YIL048W NEO1
SGTC_2881 9058953 51.95 µM -0.468858714243887 0.345843310103227 no 2224 0.319585314233962 3193 17122249
SGTC_1000 4048-0884 8.67 µM -0.468925723877939 0.34582063894847 no 2225 0.319561364243851 3328 13040088
SGTC_2489 cantharidin 73.42 µM -0.469868610031424 0.345501693945134 no 2226 0.319224446055927 3314 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2313 7726885 200 µM -0.471701969526091 0.344881847402122 no 2227 0.31856976556565 3309 726423
SGTC_2468 5987765 72.9 µM -0.472246490259288 0.344697828662404 no 2228 0.318375429756141 3253 26772094
SGTC_1004 4084-0029 199 µM -0.473622920493768 0.344232833121539 no 2229 0.317884413896599 3337 716894 YLR208W SEC13
SGTC_85 0868-0259 160.055 µM -0.474316686920156 0.343998549144106 no 2230 0.317637046886097 3258 83173
SGTC_1688 st021091 57.6 µM -0.476059598326953 0.34341023467111 no 2231 0.317015959556394 3348 3656366
SGTC_113 0099-0221 2.5 µM -0.47682430553953 0.343152229662933 no 2232 0.316743618268933 3396 89219
SGTC_1804 st050076 49.1 µM -0.476936980943483 0.343114220219329 no 2233 0.3167034986668 3333 3895976
SGTC_1441 4106-0040 13 µM -0.478098932222578 0.34272234514065 no 2234 0.316289896016117 3306 2904180
SGTC_964 1287-0107 19.4 µM -0.478283323362185 0.342660173659889 no 2235 0.316224282130243 3366 51516812 YPR165W RHO1
SGTC_510 ag-490 170 µM -0.479522176414421 0.34224257800056 no 2236 0.315783597820458 3381 5328779
SGTC_233 rapamycin 362 pM -0.480004489694817 0.342080050767317 no 2237 0.315612100285392 3340 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2585 alliin 100 µM -0.480148374208548 0.342031571032056 no 2238 0.315560946537325 3418 87310 A garlic compound which reacts with lipids.
SGTC_146 3448-8650 53.125 µM -0.480553066959128 0.341895229826291 no 2239 0.315417089329854 3254 2891488 YIL048W NEO1
SGTC_131 0141-0277 33.849 µM -0.480661913168069 0.341858562997362 no 2240 0.315378402251739 3358 1547771
SGTC_3045 9092950 49.47 µM -0.481014079527235 0.341739939564179 no 2241 0.315253246052806 3387 44120432
SGTC_1452 4194-0072 190 µM -0.48137085468089 0.341619779641926 no 2242 0.315126473554369 3380 1343545
SGTC_1198 1612-1005 86.7 µM -0.481852520695745 0.341457582619533 no 2243 0.314955358269623 3416 6998509
SGTC_170 4197-0004 226 µM -0.482059527138079 0.341387883915781 no 2244 0.314881829954184 3358 218692
SGTC_1013 4112-3890 241 µM -0.487211883432978 0.339654842923559 no 2245 0.313054092423244 3180 705171
SGTC_1172 0370-0043 85 µM -0.489960990456106 0.338731538437362 no 2246 0.312080751608496 3363 376585
SGTC_2057 5236571 38.335 µM -0.491406106801333 0.338246575119207 no 2247 0.311569622947483 3414 54684039 YBR257W POP4
SGTC_106 0092-0003 11.579 µM -0.491932105422779 0.338070122975704 no 2248 0.311383670534833 3296 1072148
SGTC_3254 9136651 49.47 µM -0.492764628689289 0.337790916408513 no 2249 0.311089453073927 3287 16454030
SGTC_894 0960-0238 55.9 µM -0.492802673232434 0.337778159393098 no 2250 0.311076010843648 3381 6741907 YDL195W SEC31
SGTC_2904 7225135 42.03 µM -0.493357094287996 0.337592273255234 no 2251 0.310880146558363 3385 4446116
SGTC_2302 7771753 200 µM -0.493980025900772 0.337383464181344 no 2252 0.310660142966495 3321 2203047
SGTC_2404 5161160 200 µM -0.495969020696277 0.336717080907313 no 2253 0.309958134043196 3310 2831543
SGTC_1526 st051518 75 µM -0.497440846028358 0.336224297303386 no 2254 0.309439103809423 3261 673993
SGTC_1859 st055998 20 µM -0.498129170648106 0.335993934989962 no 2255 0.309196500642051 3418 676301
SGTC_1122 capsaicin 818.572 nM -0.498171020531413 0.335979931031527 no 2256 0.309181753139993 3387 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3031 9088762 49.47 µM -0.498733611415615 0.335791696957323 no 2257 0.308983531302644 3244 205253
SGTC_1998 st075797 76.8 µM -0.499139465847975 0.335655930009787 no 2258 0.308840568113125 3389 24208315
SGTC_1363 1636-0063 10.4 µM -0.499700563779229 0.335468266137276 no 2259 0.308642967727441 3303 6072185
SGTC_3068 9116768 49.47 µM -0.50102117384254 0.335026739149334 no 2260 0.308178110653351 3366 41904888
SGTC_3328 9140624 29.0385 µM -0.50132898159765 0.33492386077796 no 2261 0.30806980594253 3389 4904392
SGTC_1548 st061468 90.8 µM -0.501557465566722 0.334847502749313 no 2262 0.307989422769584 3335 390799
SGTC_1040 k898-0338 155 µM -0.502175409030293 0.334641023807245 no 2263 0.307772069616379 3421 20969351
SGTC_1128 3448-9350 235 µM -0.50238664471077 0.334570453214854 no 2264 0.307697785821082 3304 619386
SGTC_122 0236-0016 402.397 µM -0.504254498841167 0.333946686432669 no 2265 0.307041273746222 3370 6808838
SGTC_1511 0906-3109 28.5 µM -0.507579311097613 0.332837506164415 no 2266 0.30587420136465 3365 2882180
SGTC_2005 4024620 188 µM -0.507977951749117 0.332704614817344 no 2267 0.305734402839378 3364 236743
SGTC_1954 st077032 68.9 µM -0.508757142680769 0.332444923453262 no 2268 0.30546123161865 3338 698907
SGTC_1488 4013-0813 75.9 µM -0.509659157901143 0.332144397219526 no 2269 0.305145135492037 3296 2910057
SGTC_407 eburnamonine 100 µM -0.510356194858268 0.331912237917204 no 2270 0.304900970066442 3302 3195
SGTC_52 0329-0193 875 nM -0.511265706921582 0.331609407413654 no 2271 0.304582507228738 3470 3739292
SGTC_319 1348-1596 45.5 µM -0.512016014916198 0.331359668196726 no 2272 0.304319900641584 3441 5380505
SGTC_3192 9110362 49.47 µM -0.512856148726702 0.331080119527929 no 2273 0.30402597487128 3421 16649480
SGTC_2629 bisabolol 100 µM -0.513089608124385 0.331002454248013 no 2274 0.303944320197911 3420 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2059 5238311 157 µM -0.514005432213658 0.330697855945665 no 2275 0.303624096368791 3265 703021
SGTC_214 4373-3496 70 µM -0.514586957592655 0.330504501810483 no 2276 0.303420840467344 3441 3779166
SGTC_1708 st033234 31.827 µM -0.515744282462817 0.330119831995188 no 2277 0.303016510986509 3438 674664
SGTC_2736 butenafine 14.65 µM -0.516018435122192 0.330028735850184 no 2278 0.302920766812671 3300 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_100 0086-0128 49.5915 µM -0.517508584359886 0.329533761629145 no 2279 0.302400589005534 3334 93297
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.517921891769514 0.329396528546627 no 2280 0.302256383619247 3274 803109
SGTC_2470 5664817 21.68 µM -0.519380610071212 0.328912364808346 no 2281 0.30174767505078 3397 2859561
SGTC_3198 9112019 49.47 µM -0.520089728775267 0.328677104546895 no 2282 0.301500518470146 3384 45595555
SGTC_3260 9137109 49.47 µM -0.520271141578199 0.328616929158715 no 2283 0.301437303399212 3319 17478346
SGTC_1321 1326-2144 215 µM -0.520366059250365 0.328585446339241 no 2284 0.301404230782489 3377 3513030
SGTC_1079 idarubicin 2.36 µM -0.521135645648533 0.328330230601514 no 2285 0.301136140459732 3390 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_298 1391-0729 10 µM -0.523121401664081 0.327672070200312 no 2286 0.300444886532239 3341 3237558
SGTC_602 3130-1533 38.1 µM -0.526065949930457 0.326697112325825 no 2287 0.299421192835166 3429 720941
SGTC_1022 4477-0945 21.3 µM -0.526595344899872 0.326521951619402 no 2288 0.29923731266976 3367 4648966
SGTC_2047 4141938 200 µM -0.529897033485106 0.325430387453892 no 2289 0.298091661535906 3328 3807862
SGTC_1494 4358-1428 177 µM -0.530124987510798 0.325355079158135 no 2290 0.298012637694528 3450 1564571
SGTC_755 1995-0008 37.3 µM -0.531288730219744 0.324970729130703 no 2291 0.297609356890026 3417 689533
SGTC_1748 st037455 53.6035 µM -0.53192284006825 0.324761379623277 no 2292 0.297389718765958 3445 580690
SGTC_1349 flufenamic acid 69 µM -0.533159219890016 0.32435335163804 no 2293 0.296961684036093 3370 3371 A non-steroidal anti-inflammatory.
SGTC_935 2996-0153 430 µM -0.533207759450119 0.32433733699175 no 2294 0.296944885390098 3448 23738523
SGTC_526 4469-0568 170 µM -0.53477394050256 0.323820781745012 no 2295 0.296403092523061 3375 2901964
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.535601042695786 0.323548125046203 no 2296 0.296117153986878 3417 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_634 1611-4317 11.2 µM -0.536714752445113 0.323181136947625 no 2297 0.295732332089606 3459 2843522
SGTC_809 3998-0021 90 µM -0.536995701569535 0.323088586136942 no 2298 0.295635291601154 3414 715485
SGTC_478 N-arachidonylglycine 10 µM -0.541164075781622 0.321716721317586 no 2299 0.294197248153744 3373 5283389
SGTC_2770 toltrazuril 17.5 µM -0.54327842973836 0.321021787156034 no 2300 0.293469056715078 3449 68591 Kills coccidiodes.
SGTC_920 mycophenolic acid 780.421 nM -0.543720856425709 0.320876451975067 no 2301 0.293316788992777 3359 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1382 3002-2117 298 µM -0.54372261133097 0.320875875551197 no 2302 0.293316185088951 3491 1497314
SGTC_425 3825-7017 13.1 µM -0.544436011563744 0.320641584763679 no 2303 0.293070735176821 3485 3397440
SGTC_18 0111-0177 500 nM -0.545639776315783 0.320246413290727 no 2304 0.292656788365896 3469 721752
SGTC_1617 st002906 78 µM -0.546701342804131 0.319898091680345 no 2305 0.292291965765477 3443 5150859
SGTC_75 0159-0059 199.013 µM -0.547154623288965 0.319749409451988 no 2306 0.292136253872917 3582 5377270
SGTC_495 decylubiquinone 155 µM -0.547160364647243 0.319747526393251 no 2307 0.2921342818367 3412 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2478 5763493 32.33 µM -0.547495654147582 0.319637565732394 no 2308 0.292019127668073 3383 1365576 YLR208W SEC13
SGTC_721 1187-1332 279 µM -0.550203261324139 0.318750167640496 no 2309 0.29108998346302 3362 25730
SGTC_2484 5809818 12.04 µM -0.550556346220399 0.31863452311601 no 2310 0.290968920468461 3396 2870548
SGTC_808 0711-0032 135 µM -0.550639323963972 0.318607348300799 no 2311 0.29094047312158 3429 4252555
SGTC_802 4112-3352 742 µM -0.551809423969512 0.318224250064584 no 2312 0.290539464963751 3475 704594
SGTC_2774 tamoxifen 10.92 µM -0.552088996161005 0.318132745089653 no 2313 0.290443690312761 3472 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1905 st060207 84.5 µM -0.552793031641519 0.317902360945917 no 2314 0.290202570328676 3377 1948547
SGTC_1205 4161-2785 76 µM -0.553840083138074 0.317559860738607 no 2315 0.289844146837587 3421 3498106
SGTC_1049 3226-0134 66 µM -0.553918801002174 0.317534117704379 no 2316 0.289817208771892 3450 5702385
SGTC_621 3584-0052 32.1 µM -0.554897243986766 0.317214212028604 no 2317 0.289482473552834 3475 2273927
SGTC_383 2324-0395 7.37 µM -0.558782310304771 0.315945323929212 no 2318 0.288155148314669 3478 3146421
SGTC_2723 salbutamol 83.58 µM -0.558898304827627 0.315907472579185 no 2319 0.288115563198434 3439 9884233 β2-adrenoceptor agonist
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.559716494489107 0.315640535648673 no 2320 0.287836414883953 3460 66535 A nucleotide analog.
SGTC_2272 7805186 180 µM -0.560697364275293 0.315320650553523 no 2321 0.2875019321528 3462 2956062 YPR165W RHO1
SGTC_1063 disulfiram 1.84 µM -0.561586110948771 0.31503092850023 no 2322 0.287199022781063 3438 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2671 danthron 100 µM -0.563185047229831 0.314509978645117 no 2323 0.28665444189252 3423 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2019 4016004 108 µM -0.566852295753648 0.313316546757475 no 2324 0.28540726851141 3409 45595336
SGTC_111 0083-0039 52.457 µM -0.567349422407293 0.313154916930215 no 2325 0.28523840266397 3415 759313
SGTC_1695 st026914 34.495 µM -0.56798647014611 0.312947847300187 no 2326 0.285022077513367 3437 3289191
SGTC_2028 5153890 36.43 µM -0.568263875306351 0.312857696378924 no 2327 0.284927902257683 3440 2830968 YPR165W RHO1
SGTC_2976 9009005 19.48 µM -0.569527430647462 0.312447208749045 no 2328 0.284499130383564 3519 2993148
SGTC_2942 9052777 62.25 µM -0.569951352802629 0.312309542450971 no 2329 0.284355346722446 3509 6469503
SGTC_2884 9058502 51.95 µM -0.573051309298104 0.311303646489305 no 2330 0.283304976821079 3487 6471554
SGTC_2098 5376439 882.5 nM -0.573102460183043 0.311287060468488 no 2331 0.283287660790389 3477 2844116
SGTC_574 1315-0397 40 µM -0.573697923249421 0.311094005733312 no 2332 0.283086116949046 3504 6794277
SGTC_853 0419-0306 21 µM -0.574955816257765 0.310686355848409 no 2333 0.282660589638485 3392 762713
SGTC_1793 st048256 72.231 µM -0.576211449457042 0.310279669973266 no 2334 0.282236133604436 3451 672022
SGTC_2526 patulin 37.61 µM -0.576666132318322 0.310132460323366 no 2335 0.282082507648718 3507 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1675 st018485 24.5 µM -0.577546858944813 0.309847399869562 no 2336 0.281785046753925 3419 3323024
SGTC_2386 9075165 157.42 µM -0.578037797160184 0.309688549913394 no 2337 0.281619300544673 3455 16452277
SGTC_704 1310-0270 142 µM -0.578447392254294 0.309556046857759 no 2338 0.281481052664174 3462 5718033
SGTC_180 1486-1293 102.781 µM -0.578638855620547 0.309494117394011 no 2339 0.281416440552267 3553 4140536
SGTC_1386 3228-0095 33.8 µM -0.579945662611233 0.309071570854373 no 2340 0.280975630664957 3488 870181
SGTC_1256 0570-0116 285 µM -0.579967038870533 0.309064661093675 no 2341 0.280968422836579 3436 410638
SGTC_2593 nobiletin 86.24 µM -0.580109337618225 0.309018665511517 no 2342 0.2809204436156 3416 72344 An anti-infammatory.
SGTC_643 k048-0106 28.4 µM -0.580877887942023 0.308770296827124 no 2343 0.28066137807629 3496 6763920
SGTC_1117 retinoic acid 1.10837 µM -0.581049297040149 0.308714915300551 no 2344 0.280603614685129 3530 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2452 5863136 48.41 µM -0.581330497500991 0.308624070089371 no 2345 0.280508865010019 3448 2184096
SGTC_2465 5809242 33.21 µM -0.582084544562359 0.308380523886105 no 2346 0.280254867512984 3470 2731748
SGTC_1574 spiramycin 23.7 µM -0.583433407469046 0.30794507118062 no 2347 0.279800786951805 3473 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1329 1447-1697 50.6 µM -0.583789860464623 0.307830042773144 no 2348 0.279680850435128 3479 2840515
SGTC_813 k007-0158 173 µM -0.584564431450039 0.307580151597009 no 2349 0.279420314892929 3469 6523916
SGTC_1299 1079-1439 3.74 µM -0.585897101187462 0.30715041620857 no 2350 0.278972332726822 3409 323161
SGTC_2996 9066192 71.4286 µM -0.589901727543336 0.305860670990499 no 2351 0.277628267933057 3463 6472854
SGTC_1311 1190-0148 100 µM -0.591150378597248 0.305459016539624 no 2352 0.277209833584031 3534 1961333
SGTC_1605 st000082 49.1 µM -0.591269762333462 0.305420626541489 no 2353 0.277169843170176 3502 1114022
SGTC_1794 st048918 76.9 µM -0.591321297990463 0.30540405498068 no 2354 0.277152580951845 3460 672303
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.591480187317668 0.305352965794103 no 2355 0.277099363203754 3482 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_665 3914-0008 307 µM -0.595626510723933 0.304021101927061 no 2356 0.275712381112849 3459 1069549
SGTC_2357 9067248 200 µM -0.595852087496183 0.303948717470121 no 2357 0.275637021660462 3495 9150235
SGTC_650 1328-0195 38 µM -0.596257835241495 0.303818537993933 no 2358 0.275501497171624 3512 2780821
SGTC_1912 st060209 90.8 µM -0.596580829317155 0.303714926861232 no 2359 0.27539363681077 3460 688787
SGTC_2090 5301565 104.445 µM -0.597692723635654 0.30335837028394 no 2360 0.275022490741914 3522 2056344
SGTC_1522 st012842 45.6 µM -0.597696867928367 0.303357041663342 no 2361 0.275021107853908 3460 3491067 YOR116C RPO31
SGTC_458 nppb 133 µM -0.598262371203231 0.303175771115997 no 2362 0.274832440066063 3583 4549 A chloride channel blocker.
SGTC_2784 7567673 72.73 µM -0.598432102056756 0.303121373801853 no 2363 0.274775825532662 3546 3471247
SGTC_2240 6690706 185.951 µM -0.599751750197948 0.302698586656474 no 2364 0.274335846852023 3434 805876
SGTC_669 0108-0021 26.2 µM -0.599792978654907 0.302685382193878 no 2365 0.274322106639653 3662 17201
SGTC_1289 0976-0073 69.1 µM -0.600046722497587 0.30260411995278 no 2366 0.274237548882601 3544 3391136
SGTC_2276 7947513 42.08 µM -0.600073670045279 0.302595490492593 no 2367 0.274228569621055 3429 2105100
SGTC_2356 9061756 188.97 µM -0.600359755665944 0.302503883596809 no 2368 0.274133251250998 3481 20104043
SGTC_2502 avocadyne acetate 18.59 µM -0.601301636854102 0.302202373621667 no 2369 0.273819549775163 3506 3952079
SGTC_3163 9099914 49.47 µM -0.601823327847814 0.30203543075064 no 2370 0.273645872611259 3538 16268368
SGTC_1422 4031-0024 15.5 µM -0.602217303398789 0.301909384705984 no 2371 0.273514749575529 3481 782427
SGTC_698 k064-0052 127 µM -0.604391401726681 0.301214242933109 no 2372 0.272791725467311 3579 5088751
SGTC_2203 7227154 166.4 µM -0.604391443315914 0.301214229642351 no 2373 0.272791711645356 3537 896304
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.604515073063804 0.301174722192519 no 2374 0.272750625507322 3488 2374 Ca(2+)-ATPase inhibitor.
SGTC_381 3461-2219 42.7 µM -0.605802043746571 0.300763593151696 no 2375 0.27232310621719 3516 2883159
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.607196882260547 0.300318291388469 no 2376 0.271860130529091 3573 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2255 7941087 197.44 µM -0.607202635241039 0.300316455368378 no 2377 0.271858221807374 3577 935561
SGTC_2177 5811945 192 µM -0.608498289943862 0.299903086292545 no 2378 0.271428519896115 3560 5343475
SGTC_1086 cerivastatin 2.18 µM -0.60905365594108 0.299725979756095 no 2379 0.271244437269052 3519 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1126 isoteolin 1.0172 µM -0.609832488909365 0.299477689304525 no 2380 0.270986388749787 3522 133323
SGTC_922 1866-0035 480 µM -0.610317466946315 0.299323126363572 no 2381 0.270825764252395 3524 3156169
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.611242423779681 0.299028442139842 no 2382 0.27051955079149 3552 676296 Flavone; oxidizing agent.
SGTC_658 3253-0951 102 µM -0.611302863045029 0.299009191234842 no 2383 0.270499547970229 3524 1184878
SGTC_199 4063-0024 41.6 µM -0.612235519517484 0.298712196111112 no 2384 0.270190972142288 3549 306215
SGTC_271 rotenone 740 µM -0.612239095076946 0.298711057768055 no 2385 0.270189789482614 3571 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2353 9059630 146.67 µM -0.612282161213653 0.298697347051088 no 2386 0.270175545038764 3524 4779114
SGTC_2626 ethyl orsellinate 100 µM -0.612793802059906 0.298534480807694 no 2387 0.270006344779877 3509 75653 A natural product.
SGTC_2903 5923464 63.88 µM -0.613916253614532 0.298177322028598 no 2388 0.269635334526565 3567 2876576
SGTC_1054 3429-0080 167 µM -0.616217958035866 0.297445540001706 no 2389 0.268875338855381 3559 1162877
SGTC_3093 9117344 49.47 µM -0.616982776454305 0.297202562574171 no 2390 0.268623043135933 3547 24824913
SGTC_289 k017-0060 526 µM -0.617592212643423 0.297009013960415 no 2391 0.268422089587029 3505 5512909
SGTC_317 4495-0002 170 µM -0.618788795477741 0.296629163415511 no 2392 0.268027752215527 3518 15991618
SGTC_405 ebelactone b 50 µM -0.618789431300249 0.2966289616353 no 2393 0.268027542755916 3508 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2372 9071633 200 µM -0.619125088462722 0.296522448590225 no 2394 0.267916978405474 3578 21321366
SGTC_2782 7736369 71.43 µM -0.619924254764096 0.296268922189658 no 2395 0.267653828171211 3559 2950836 YOL077C BRX1
SGTC_2635 hydroquinidine 100 µM -0.620231200181079 0.296171573685357 no 2396 0.267552791532835 3533 442912 An experimental heart treatment.
SGTC_558 k064-0027 21.3 µM -0.620680196133668 0.296029199939196 no 2397 0.267405031035995 3534 5088526
SGTC_1960 st011366 51.8 µM -0.620834594858169 0.295980248350639 no 2398 0.267354229328268 3559 3972846
SGTC_2280 7785178 200 µM -0.621090933182183 0.295898985367625 no 2399 0.267269897256716 3509 2954328
SGTC_2802 7925815 54.55 µM -0.623769320443819 0.295050511100335 no 2400 0.266389545301492 3533 1262923
SGTC_2546 rhodinyl acetate 100 µM -0.623861175574421 0.295021432611672 no 2401 0.266359379725593 3551 6708682
SGTC_2128 5255449 168.493 µM -0.625053984232112 0.294643946285471 no 2402 0.265967813829672 3543 736008
SGTC_2576 guaiol 23.12 µM -0.625166537432635 0.294608338253212 no 2403 0.265930880807865 3549 227829
SGTC_3209 9113616 49.47 µM -0.631651169103479 0.292560180602602 no 2404 0.26380742134201 3604 16649353
SGTC_1322 1348-1070 12 µM -0.633350876877798 0.292024427839985 no 2405 0.263252268070588 3564 6758089
SGTC_1557 sumaresinolic acid 42.3 µM -0.633952000282307 0.291835061411976 no 2406 0.263056073940164 3529 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_716 1683-5115 658 µM -0.634599549341806 0.291631133959479 no 2407 0.262844811081169 3613 723597
SGTC_1310 1188-0297 994 nM -0.634993597278661 0.291507072111636 no 2408 0.262716295431114 3547 1588352
SGTC_302 1094-0063 18.9 µM -0.636523982037522 0.291025480159189 no 2409 0.26221747745669 3530 5440289
SGTC_1370 2001-0092 44.6 µM -0.636541612021133 0.291019934401495 no 2410 0.262211733917909 3655 790957
SGTC_3003 9075612 71.4286 µM -0.637251124811823 0.290796788225291 no 2411 0.261980640626833 3573 6501993
SGTC_2419 paclitaxel 166.5 µM -0.638291735127038 0.290469654604068 no 2412 0.261641895528186 3522 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_272 doxorubicin 8.13 µM -0.638464522368205 0.290415352664315 no 2413 0.261585670659281 3593 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2161 5662504 8.5105 µM -0.639097458806328 0.290216479988197 no 2414 0.261379766485788 3542 2859334
SGTC_2611 pyromycin 23.93 µM -0.639184671137491 0.29018908231799 no 2415 0.26135140146994 3550 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1035 k081-0041 55.2 µM -0.641692503095996 0.289401768253254 no 2416 0.260536428931417 3613 731709
SGTC_1870 st057514 26.5 µM -0.642715887218656 0.289080773440373 no 2417 0.260204235139584 3564 5393161
SGTC_2441 5730946 39.09 µM -0.64399209166399 0.288680713737178 no 2418 0.259790281111725 3607 1774275
SGTC_474 dl-dihydrosphingosine 5 µM -0.644615418515148 0.288485410435741 no 2419 0.259588220276845 3627 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3012 9080433 71.4286 µM -0.645360316886541 0.288252097555137 no 2420 0.259346856661598 3605 17688859
SGTC_3058 9093861 49.47 µM -0.6455995451254 0.288177186715745 no 2421 0.259269366005293 3622 17217477
SGTC_432 NS 1619 61.3 µM -0.646745577208342 0.2878184509032 no 2422 0.258898310063411 3594 4552 A K+/calcium channel activator.
SGTC_1243 0416-0003 5.65 µM -0.648342458023133 0.287318940533514 no 2423 0.258381739296047 3562 2141977
SGTC_2261 9010538 184.68 µM -0.649776569362963 0.286870694961329 no 2424 0.257918277965619 3546 6457250
SGTC_909 3448-9333 149 µM -0.649807935379849 0.286860894909178 no 2425 0.257908146241296 3567 3344074
SGTC_3165 9101544 49.47 µM -0.651003008046079 0.286487622584257 no 2426 0.257522272560253 3594 5002184
SGTC_1573 oleylamine 1.06 µM -0.651470627449 0.286341627795001 no 2427 0.257371365901974 3613 5356789 An amine of the fatty acid oleic acid.
SGTC_1006 4099-6547 255 µM -0.651579899770279 0.286307517130409 no 2428 0.257336108975389 3605 3146833
SGTC_1468 k284-1086 134 µM -0.651901698871461 0.286207074892467 no 2429 0.257232294452723 3614 15996457
SGTC_1378 2093-0007 380 nM -0.655470113631557 0.285094399000623 no 2430 0.256082561174711 3599 3618014
SGTC_2170 morpholine 200 µM -0.656840905169859 0.284667518135195 no 2431 0.255641609621338 3604 121171 Reacts with secondary amines.
SGTC_413 propylparaben 100 µM -0.656980443846695 0.284624081241261 no 2432 0.255596745541753 3576 7175 A pharmaceutical preservative.
SGTC_3046 9092212 49.47 µM -0.657003959186301 0.284616761479779 no 2433 0.255589185361388 3619 25236637
SGTC_99 0109-0120 622.8 µM -0.660713431221035 0.283463218683304 no 2434 0.25439805432079 3658 759414
SGTC_2093 5331342 194.4 µM -0.660774300445059 0.283444308747301 no 2435 0.254378533181727 3617 33839
SGTC_1029 k015-0030 64.7 µM -0.662013771886308 0.283059379963831 no 2436 0.25398119780333 3625 2208316
SGTC_1622 st003707 19.4 µM -0.662279674371119 0.28297683430026 no 2437 0.253896000313887 3624 10140899
SGTC_336 4111-0029 111 µM -0.662425265417669 0.282931642516801 no 2438 0.25384935802066 3568 3131175
SGTC_1740 st038286 13.222 µM -0.662434614028417 0.282928740805717 no 2439 0.25384636320553 3627 716786
SGTC_376 3970-0862 59.1 µM -0.662970282380554 0.2827624988184 no 2440 0.253674793536724 3604 3135186
SGTC_3019 9081971 49.47 µM -0.662984503958184 0.282758085862653 no 2441 0.253670239325642 3662 16451803
SGTC_3221 9128209 49.47 µM -0.663163599486067 0.282702515349948 no 2442 0.253612890795948 3629 16460723
SGTC_633 0437-0093 97.7 µM -0.663714076764129 0.282531743809979 no 2443 0.253436664032576 3625 2831118
SGTC_2907 7721985 69.9 µM -0.668847467379398 0.280941632693067 no 2444 0.251796391835109 3591 3267881
SGTC_69 0096-0274 206.684 µM -0.668954492429112 0.280908526861526 no 2445 0.251762253869613 3747 6741392
SGTC_1831 st055328 12 µM -0.669454643796787 0.280753841101944 no 2446 0.251602752123114 3631 1103068
SGTC_88 0180-0332 8.668 µM -0.669749973743441 0.280662521426908 no 2447 0.251508594423373 3673 3101745
SGTC_369 0957-0393 4.5 µM -0.670332323149413 0.280482493895697 no 2448 0.251322983158995 3611 6997992
SGTC_520 3584-0023 682 µM -0.670461428023143 0.280442589977887 no 2449 0.251281843584976 3591 1340790
SGTC_3053 9095903 49.47 µM -0.670946948989528 0.280292549074374 no 2450 0.251127163057153 3679 17174018
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.673326519554708 0.279557751380038 no 2451 0.250369792411295 3658 279621
SGTC_2227 7312221 64.1025 µM -0.674490759476595 0.279198581831598 no 2452 0.249999679274407 3649 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2287 7945887 168.79 µM -0.674677555484411 0.27914097590465 no 2453 0.249940323659256 3655 1245853
SGTC_286 k060-0067 22.9 µM -0.675580234162285 0.278862680739278 no 2454 0.249653597220068 3610 5985051
SGTC_174 3553-0389 74.3 µM -0.677800054979703 0.278178886405925 no 2455 0.248949238101041 3626 738071
SGTC_699 0375-0592 111 µM -0.677941046270739 0.278135483034503 no 2456 0.248904536677511 3670 762578
SGTC_748 act1.228 77.9 µM -0.679586211827904 0.277629272400244 no 2457 0.248383251282603 3611 4421505 YNR035C ARC35
SGTC_2283 7944793 200 µM -0.680880727332959 0.277231272010574 no 2458 0.24797348194119 3632 2970533
SGTC_2816 7982706 58.44 µM -0.681044502856961 0.277180938919055 no 2459 0.24792166572476 3644 2981853
SGTC_2945 9067681 61.76 µM -0.681870318953676 0.27692720919045 no 2460 0.247660477463278 3725 16456930
SGTC_1341 1486-1360 280 µM -0.68193856032064 0.27690624730597 no 2461 0.247638900730045 3647 3976547
SGTC_2729 fluphenazine 10.66 µM -0.684348267315159 0.276166549643023 no 2462 0.246877637410434 3597 3372 An atypical antipsychotic.
SGTC_186 3455-3465 67.277 µM -0.685980663609769 0.275666011433721 no 2463 0.246362650970987 3613 755278
SGTC_2647 atorvastatin 60.16 µM -0.686039059299407 0.275648113953294 no 2464 0.246344239041775 3632 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.686305158508104 0.275566565417757 no 2465 0.246260348356296 3689 364106
SGTC_707 0865-0008 204 µM -0.687156324282592 0.275305797580117 no 2466 0.245992111923238 3650 723043
SGTC_2211 7117706 200 µM -0.687222642633795 0.275285485025727 no 2467 0.245971218938944 3605 822771
SGTC_2448 5185112 27.17 µM -0.687663310166273 0.275150532326542 no 2468 0.245832414887581 3647 5718189
SGTC_1147 3809-1045 12.3 µM -0.688042500461048 0.275034432872565 no 2469 0.245713008961718 3615 325925
SGTC_1812 st052057 4.327 µM -0.690224871567493 0.274366709902978 no 2470 0.245026392420514 3660 3645418
SGTC_1513 0337-0559 19 µM -0.694055535560549 0.273196610178513 no 2471 0.243823690925854 3606 775073
SGTC_1799 st045822 46.1415 µM -0.694810568299571 0.272966272841046 no 2472 0.2435870121291 3662 3674992
SGTC_549 1661-1316 519 µM -0.695008918112058 0.272905778369435 no 2473 0.243524856344283 3689 2857282
SGTC_3079 9117512 49.47 µM -0.696152139273302 0.272557238363399 no 2474 0.24316677848753 3683 7185044
SGTC_2781 5567276 71.43 µM -0.698064801124212 0.271974609408388 no 2475 0.242568334777472 3676 2853274
SGTC_152 4469-0003 551.229 µM -0.699341966898343 0.271585908452145 no 2476 0.242169172962694 3646 697280
SGTC_1045 1348-1485 165 µM -0.699567336977272 0.271517346578478 no 2477 0.242098773410173 3694 6810614
SGTC_1737 st035557 69.7 µM -0.701892609460776 0.270810458089746 no 2478 0.241373069123798 3591 5716916
SGTC_2325 6158266 200 µM -0.702125731169886 0.270739639222282 no 2479 0.241300378405731 3698 3623240
SGTC_126 0417-1624 672.48 µM -0.703365582076002 0.270363146601749 no 2480 0.240913974921372 3769 41912 YDL195W SEC31
SGTC_2394 5221648 200 µM -0.703805639314374 0.270229581954083 no 2481 0.240776910655116 3749 788586
SGTC_3280 9140961 49.47 µM -0.703818814307145 0.270225583634723 no 2482 0.24077280770528 3689 4901226
SGTC_2100 5377183 190 µM -0.706069924424719 0.269542856088257 no 2483 0.240072326988405 3719 2844202
SGTC_2194 5927483 104.545 µM -0.708675260323793 0.268753777832764 no 2484 0.239263010359851 3710 760979
SGTC_933 2914-0560 114 µM -0.708769369392307 0.268725296742598 no 2485 0.239233804416739 3707 463887
SGTC_2541 muurolladie-3-one 83.07 µM -0.710615958331879 0.26816675356268 no 2486 0.238661125641748 3717 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1842 st055362 61.2 µM -0.711908956788112 0.267776004581884 no 2487 0.238260577695452 3689 676032
SGTC_3087 9117406 49.47 µM -0.712780480633426 0.267512788749233 no 2488 0.237990802992302 3671 42546093
SGTC_760 0568-0725 82.9 µM -0.713405078332449 0.267324229329406 no 2489 0.237797565770307 3723 3916171
SGTC_1620 st003704 16.5 µM -0.714350221464369 0.26703902820797 no 2490 0.23750532232334 3670 2834414
SGTC_1725 st036284 20.55 µM -0.716095411104497 0.266512813611535 no 2491 0.236966218555607 3716 707914
SGTC_1057 3448-5381 134 µM -0.716628761972441 0.26635210082068 no 2492 0.236801596275541 3729 5497911
SGTC_1630 st005209 31.3 µM -0.717598402023427 0.266060048179328 no 2493 0.23650247161117 3687 3367314
SGTC_631 k072-0230 41.5 µM -0.717679211364997 0.266035715974439 no 2494 0.236477552094198 3719 5773147
SGTC_2570 licareol 100 µM -0.719035187484765 0.265627591178034 no 2495 0.236059619670237 3703 443158
SGTC_2793 7325131 81.82 µM -0.720110125665837 0.265304279599647 no 2496 0.235728596798312 3700 4176441
SGTC_37 0566-0070 1.56 µM -0.720475750899035 0.265194355220888 no 2497 0.235616062352313 3722 1626686
SGTC_1098 clofazimine 15.1 µM -0.721530920129042 0.264877250773475 no 2498 0.235291461922164 3756 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1271 0832-2808 169 µM -0.723157080923777 0.264388926907614 no 2499 0.234791691837735 3737 3663794
SGTC_2929 9013348 24.6 µM -0.72422380119832 0.264068847907026 no 2500 0.234464174310076 3738 2995952
SGTC_2408 sulbentine 18.36 µM -0.724849255951392 0.26388126645207 no 2501 0.234272257142799 3716 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1687 st020778 55.3625 µM -0.725012198540897 0.263832409152214 no 2502 0.234222273434728 3717 4259299
SGTC_877 0771-0151 33.1 µM -0.72580684639893 0.263594205155175 no 2503 0.233978594617013 3751 6166523
SGTC_2338 7999974 200 µM -0.727542513507318 0.263074302673036 no 2504 0.233446840880274 3760 315925
SGTC_1521 st012942 49.4 µM -0.727809803628989 0.262994285061727 no 2505 0.233365011214837 3769 24207259
SGTC_2515 chrysin 20.77 µM -0.730117747488946 0.262303882672191 no 2506 0.232659106987489 3740 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2371 9071574 200 µM -0.730568172519431 0.262169250081767 no 2507 0.23252147922156 3698 45596039
SGTC_2818 7996756 12.99 µM -0.732841599209765 0.261490260863075 no 2508 0.231827523002078 3736 2241621
SGTC_3217 9129673 49.47 µM -0.737032594120834 0.260240934928032 no 2509 0.230551264162221 3720 17248312
SGTC_1232 0279-0259 161 µM -0.737169226412805 0.260200256991763 no 2510 0.230509722538422 3758 1560000
SGTC_1421 4029-0249 71.4 µM -0.738845999962346 0.259701317796535 no 2511 0.230000257864978 3810 2894095
SGTC_206 4546-0025 72.014 µM -0.73945595634175 0.259519942300429 no 2512 0.229815087402256 3748 6620745 YIL048W NEO1
SGTC_1257 0669-0121 16 µM -0.739530853075477 0.259497675656948 no 2513 0.229792356018818 3770 4307855
SGTC_1431 4049-0260 9.09 µM -0.740160659259676 0.259310474624938 no 2514 0.229601257764597 3711 3854841
SGTC_2846 9008642 19.48 µM -0.74030684033293 0.259267034336645 no 2515 0.229556915665445 3772 2992898
SGTC_2348 9022543 33.42 µM -0.74128085342809 0.258977685180535 no 2516 0.229261584170996 3751 3162678 YDL140C RPO21
SGTC_1418 3966-3099 2.4 µM -0.741558232905439 0.258895314885376 no 2517 0.229177518648975 3727 740335
SGTC_1090 efavirenz 20.7 µM -0.741730164813938 0.258844264985961 no 2518 0.229125419848499 3804 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1594 piperine 70.1 µM -0.742798043333515 0.258527307939221 no 2519 0.228801980143682 3731 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2456 5770359 74.46 µM -0.743533279753999 0.25830919929884 no 2520 0.228579440343134 3725 3118787
SGTC_2316 5844804 197.44 µM -0.744234263872111 0.258101340473808 no 2521 0.228367381212175 3814 776813
SGTC_25 0118-0223 35.662 µM -0.745648222420814 0.257682331478803 no 2522 0.227939972283665 3764 5333628
SGTC_2400 5203494 178.7 µM -0.745823864893769 0.257630306691361 no 2523 0.227886910823466 3700 6777674
SGTC_1130 3454-2858 15.9 µM -0.746160355123269 0.257530654503282 no 2524 0.227785276789035 3790 715628 YIL048W NEO1
SGTC_1868 st057644 42.7 µM -0.746197720314827 0.257519589969602 no 2525 0.227773992522058 3752 688665
SGTC_219 mitoxanthrone 164.414 µM -0.747119240245836 0.25724678880143 no 2526 0.22749579359749 3744 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1317 1273-0028 910 nM -0.747335997946342 0.257182642997751 no 2527 0.227430384127391 3739 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_487 nimodipine 119 µM -0.748139881978824 0.256944819643216 no 2528 0.227187894129901 3645 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1221 2958-7315 257 µM -0.748163941899647 0.256937703451287 no 2529 0.22718063875003 3767 4562705
SGTC_1133 3473-0247 50 µM -0.749230769799332 0.256622271351578 no 2530 0.226859063194568 3783 711311
SGTC_270 tamoxifen 5.46 µM -0.750174287728578 0.256343466808686 no 2531 0.226574871248225 3809 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_881 0833-0569 170 µM -0.750461405647464 0.256258656327369 no 2532 0.22648842990868 3771 5418700
SGTC_1009 4106-0057 9.87 µM -0.751982548086379 0.255809577003468 no 2533 0.226030776965169 3750 2928005
SGTC_1302 1159-0335 255 µM -0.752104666896455 0.255773542295628 no 2534 0.225994058818347 3778 649284
SGTC_566 0958-0068 16.5 µM -0.752131209833952 0.25576571038027 no 2535 0.225986078450753 3719 6815365
SGTC_1840 st055363 71 µM -0.752751206886992 0.255582806023315 no 2536 0.22579971621223 3771 676033
SGTC_2224 6650123 117.647 µM -0.753793731734674 0.255275406500046 no 2537 0.225486544222122 3723 2908370
SGTC_667 1498-1044 59 µM -0.754292309128751 0.255128464011562 no 2538 0.225336859705714 3773 6739982
SGTC_950 1165-0508 94.1 µM -0.75632994423358 0.254528385158926 no 2539 0.224725699519434 3784 6148369
SGTC_3077 9117319 49.47 µM -0.756825709597984 0.254382495321382 no 2540 0.224577143931535 3753 17154678
SGTC_1752 st044819 83.042 µM -0.759259104015512 0.253667051611962 no 2541 0.223848788136804 3774 441209 YML126C ERG13
SGTC_3066 9117245 49.47 µM -0.760802710063077 0.253213763496186 no 2542 0.223387457739841 3845 17176980
SGTC_841 0251-0215 91.2 µM -0.761116947722105 0.253121538148078 no 2543 0.223293609302717 3807 3888614
SGTC_1472 k841-0093 193 µM -0.761650878060107 0.252964875903612 no 2544 0.22313420016225 3849 X1472
SGTC_2687 chenodiol 100 µM -0.762514605374528 0.25271155492463 no 2545 0.222876464753339 3789 5702181 A cholesterol synthesis inhibitor.
SGTC_328 k915-0120 63.5 µM -0.76363281100972 0.252383797004585 no 2546 0.222543045315302 3781 6624543
SGTC_2759 disulfiram 3.38 µM -0.764502396226077 0.252129067323843 no 2547 0.222283954629827 3732 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1078 idebenone 36.1 µM -0.765032709256031 0.251973788052859 no 2548 0.222126033739766 3837 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.766938538472239 0.251416165100231 no 2549 0.221559029436509 3794 688798
SGTC_688 0527-0193 473 µM -0.767011051330058 0.25139496158836 no 2550 0.221537472445039 3801 4007154
SGTC_2425 5628681 7.85 µM -0.767040601502815 0.251386321082377 no 2551 0.22152868796311 3845 5714958
SGTC_348 k064-0012 10.7 µM -0.767095263712931 0.251370338200294 no 2552 0.221512438863905 3712 5066323
SGTC_1447 4239-0816 81.9 µM -0.767170091228585 0.251348459982281 no 2553 0.221490196452991 3792 1341554
SGTC_2962 9082311 13.18 µM -0.76731902857815 0.251304916379418 no 2554 0.221445928761295 3781 16459453
SGTC_923 1900-2434 73.3 µM -0.768082433732524 0.2510817884433 no 2555 0.22121910617751 3769 5910570
SGTC_2857 9024691 58.44 µM -0.768146694970028 0.251063010962729 no 2556 0.221200018974978 3855 16478292
SGTC_806 3966-4455 5.86 µM -0.769643048580714 0.250625978511028 no 2557 0.220755830809793 3773 714982
SGTC_530 4358-1714 28 µM -0.76965836245405 0.250621507949378 no 2558 0.22075128757379 3867 1564641
SGTC_2200 6600604 21.907 µM -0.770166817786504 0.2504730991493 no 2559 0.220600472239897 3743 2904777
SGTC_538 2922-0838 53.3 µM -0.771333988685431 0.250132599572264 no 2560 0.220254495545267 3780 777039
SGTC_263 alizarin 107.927 µM -0.771453693487101 0.250097691894665 no 2561 0.220219029847706 3799 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_647 0140-0236 81 µM -0.772125994619107 0.249901687039964 no 2562 0.220019903799805 3784 990837
SGTC_38 0929-0051 58.268 µM -0.772221023220552 0.249873988671271 no 2563 0.219991766012503 3812 1379719
SGTC_1209 2323-2347 50.3 µM -0.772737153633987 0.249723578529754 no 2564 0.219838976847576 3742 5412760
SGTC_361 000s-0510 1.45 µM -0.773090659777206 0.249620587918505 no 2565 0.219734364208733 3802 660
SGTC_2299 7976368 114.88 µM -0.774509098088414 0.249207566571552 no 2566 0.21931489502177 3836 2979718
SGTC_1214 0358-0031 63.7 µM -0.774817909327728 0.249117695008802 no 2567 0.219223632527422 3915 4301366
SGTC_2828 7998861 71.43 µM -0.775050881970557 0.24904990572854 no 2568 0.219154796942011 3685 2988188
SGTC_1457 k015-0032 57.3 µM -0.775453568399073 0.248932757078163 no 2569 0.219035845944363 3790 4302660
SGTC_1240 0356-0016 42.1 µM -0.775649281012102 0.248875831387397 no 2570 0.21897804709992 3797 4305613
SGTC_1106 tegaserod maleate 11.7 µM -0.776250520170964 0.248700996103093 no 2571 0.218800540972864 3826 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_82 0054-0107 293.755 µM -0.776894057351549 0.24851393340801 no 2572 0.218610638810584 3783 3104697
SGTC_1524 corynanthine 62.1 µM -0.778381288766 0.248081913568046 no 2573 0.218172133108874 3911 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_623 k072-0108 16.9 µM -0.779285307297194 0.247819504795696 no 2574 0.217905833863352 3797 5382803
SGTC_788 1182-0090 188 µM -0.780521832825467 0.247460819559304 no 2575 0.217541890818619 3918 5715185
SGTC_1587 estradiol valerate 56.1 µM -0.781279911473299 0.247241057090081 no 2576 0.21731894126951 3806 13791 A steroid.
SGTC_1239 0337-0584 35.4 µM -0.781339362079461 0.247223827128554 no 2577 0.217301462536038 3853 914301 YML130C ERO1
SGTC_544 k015-0020 52.4 µM -0.782719151282185 0.246824117367872 no 2578 0.216896026722375 3813 3008304
SGTC_3191 9110352 49.47 µM -0.783381923477994 0.246632242618294 no 2579 0.216701434009425 3760 17122424
SGTC_3342 9147791 14.508 µM -0.783760989570667 0.246522537649694 no 2580 0.216590184008694 3749 1838168
SGTC_1670 st016595 4.04 µM -0.784302806998773 0.24636577645506 no 2581 0.216431226400824 3815 597879
SGTC_1326 1431-2094 10.8 µM -0.785639970606707 0.245979130669626 no 2582 0.216039220326015 3793 616278
SGTC_3178 9107506 49.47 µM -0.786478887837854 0.245736720971743 no 2583 0.215793491451439 3829 8897194
SGTC_609 0986-0026 86.3 µM -0.786682642301516 0.245677864376327 no 2584 0.215733833796241 3781 2848610
SGTC_1033 k072-0102 21.3 µM -0.787994735594875 0.245299033982687 no 2585 0.215349892598994 3767 5965931
SGTC_703 3875-0075 71.8 µM -0.788534302430236 0.245143340251385 no 2586 0.215192121120543 3843 2850814
SGTC_1761 st044296 37 µM -0.789213109023474 0.24494754395309 no 2587 0.214993730713091 3808 1826700
SGTC_901 1112-0062 60.1 µM -0.790852672164244 0.244474972435514 no 2588 0.214514984539319 3812 1908457
SGTC_720 r052-1644 49.9 µM -0.793908434617934 0.243595522044468 no 2589 0.213624369510702 3828 1422863 YOR257W CDC31
SGTC_2492 derrusnin 100 µM -0.795696139868137 0.243081812553869 no 2590 0.213104335521591 3746 1715307 Part of coumarin class of compounds.
SGTC_360 0957-0399 1.01 µM -0.797130255152484 0.242670133476041 no 2591 0.212687693306408 3851 6752301 YPR165W RHO1
SGTC_260 nsc-65238 3.989 µM -0.798009529873651 0.2424179144663 no 2592 0.212432479927442 3762 3246252
SGTC_2587 piperic acid 92.2 µM -0.79857146508699 0.242256798368562 no 2593 0.212269469500566 3847 5370536
SGTC_483 fpl-64176 144 µM -0.798850754472984 0.242176743089592 no 2594 0.212188478324017 3855 3423
SGTC_3353 9151644 39.2805 µM -0.801610600756006 0.241386434639774 no 2595 0.211389121809963 3904 4909158
SGTC_3043 9092303 49.47 µM -0.802106684792756 0.241244524926421 no 2596 0.211245624231112 3841 25236084
SGTC_2033 5192550 145 µM -0.80283295956343 0.24103684869793 no 2597 0.211035644508631 3831 182073
SGTC_2800 7887935 81.82 µM -0.803102556550758 0.240959782945914 no 2598 0.210957730087462 3859 2961002
SGTC_2102 5377816 72.7585 µM -0.803808265134693 0.240758115811744 no 2599 0.210753857843519 3860 1379702
SGTC_3085 9117376 49.47 µM -0.804572604341697 0.240539797722365 no 2600 0.210533178214043 3946 16480349
SGTC_3154 9100113 49.47 µM -0.80459855011273 0.240532388727929 no 2601 0.210525689544718 3867 25237525
SGTC_2300 7976697 71.57 µM -0.805959141474891 0.240144036616545 no 2602 0.210133204223136 3755 2236109
SGTC_543 3844-1095 191 µM -0.807403290343866 0.239732208953304 no 2603 0.209717085940381 3850 4230703
SGTC_1764 st044502 93.5 µM -0.808416811601671 0.23944341358226 no 2604 0.209425338625679 3896 8407
SGTC_2830 7992007 71.43 µM -0.808990018378633 0.239280166704502 no 2605 0.209260443878534 3750 1952075
SGTC_595 3909-8003 73.7 µM -0.810142920183836 0.238952009340265 no 2606 0.208929019433351 3935 699517
SGTC_76 0433-0009 400.328 µM -0.811019753538263 0.238702595839901 no 2607 0.208677163467371 3945 2841569
SGTC_2365 9042475 200 µM -0.814209988095142 0.237796343075336 no 2608 0.207762332255371 3933 6464479
SGTC_2347 9049783 174.81 µM -0.81440193020199 0.237741878160321 no 2609 0.207707366620554 3880 6467988 YPL169C MEX67
SGTC_674 0498-0004 451 µM -0.815178928506416 0.237521469391894 no 2610 0.207484948751722 3866 4231473
SGTC_150 3970-0969 77.2 µM -0.815731632462804 0.237364753815286 no 2611 0.207326821464756 3953 6615640
SGTC_2558 carylophyllene oxide 100 µM -0.815785005231845 0.237349623323826 no 2612 0.207311555416075 3944 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1182 1222-0449 220 µM -0.816632324021122 0.237109490334405 no 2613 0.207069288479213 3862 658318
SGTC_632 0781-2353 4.65 µM -0.8202929803122 0.236073583798004 no 2614 0.206024553576293 3911 6811515 YHR007C ERG11
SGTC_1646 st011709 75.6 µM -0.820727938271939 0.235950663683544 no 2615 0.2059006266436 3800 5757843
SGTC_858 0438-0351 2.77 µM -0.821055146994182 0.235858217003883 no 2616 0.205807428456987 3866 2799119
SGTC_3057 9095946 49.47 µM -0.821133766003418 0.235836007654768 no 2617 0.205785039296578 3868 24540043
SGTC_173 1273-0061 2.693 µM -0.821587170737824 0.235707946322178 no 2618 0.205655946676152 3863 2847414 YPL266W DIM1
SGTC_934 2950-0684 338 µM -0.821885622862791 0.235623671319451 no 2619 0.20557099813735 3927 1121253
SGTC_1427 4048-4900 550 nM -0.82232547828518 0.235499498061527 no 2620 0.205445839906515 3867 24132586
SGTC_2598 perillyl alcohol 100 µM -0.822389763686812 0.235481353014513 no 2621 0.205427551670571 3896 10819 An apoptosis inducer.
SGTC_886 0866-0150 153 µM -0.822603808726412 0.235420942723543 no 2622 0.205366666024952 3915 271463
SGTC_2788 5282734 71.43 µM -0.823202997286008 0.235251878222756 no 2623 0.20519628235165 3929 743706
SGTC_1216 1165-0504 9.65 µM -0.824519944121297 0.234880529785026 no 2624 0.204822094138326 3852 6304004
SGTC_1765 st044815 90.4 µM -0.825920992943082 0.234485822451965 no 2625 0.204424455589685 3920 645695
SGTC_274 sirtinol 40.1 µM -0.82627614848874 0.234385825385046 no 2626 0.204323730200879 3930 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2790 5423970 71.43 µM -0.827976503778614 0.233907402972865 no 2627 0.203841903286237 3934 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_971 1315-0384 26.7 µM -0.828708296119229 0.233701668043388 no 2628 0.203634745101264 3909 6769120
SGTC_1208 2323-2347 50.3 µM -0.829009443126971 0.233617033198372 no 2629 0.203549531888937 3876 5412760
SGTC_2331 7980721 200 µM -0.82935432632911 0.233520127542272 no 2630 0.203451969117403 3845 2981221
SGTC_431 k089-0097 107 µM -0.829470411530607 0.233487514812076 no 2631 0.203419136467475 3781 5499420
SGTC_2197 6588183 93.1375 µM -0.832354949588739 0.23267795061053 no 2632 0.202604311386421 3818 884136
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.832644759508288 0.23259669992796 no 2633 0.202522553790653 3880 688662
SGTC_444 curcumin 90.4 µM -0.836104920799757 0.231627833554097 no 2634 0.201547940164794 3844 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_287 k060-0039 29.6 µM -0.837621730560683 0.231203827663956 no 2635 0.201121592174332 3904 5861974
SGTC_2442 5158906 48.48 µM -0.840461527179219 0.230411162305639 no 2636 0.200324832053994 3925 1893835
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.841905590526539 0.230008667947122 no 2637 0.199920400407556 3930 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1631 benzylvanillin 81.9 µM -0.842297248566919 0.229899571525962 no 2638 0.199810795387418 3972 75506
SGTC_2030 5175110 200 µM -0.842648460708359 0.229801765956712 no 2639 0.199712539846786 3953 2831986
SGTC_1011 4112-3381 17.4 µM -0.842754565373029 0.229772222509182 no 2640 0.199682861593764 3987 2877139
SGTC_3129 9127257 49.47 µM -0.842814762974122 0.229755462225016 no 2641 0.199666025063028 3885 837894
SGTC_2892 9047358 58.44 µM -0.845826328971013 0.228917852978015 no 2642 0.198824817652454 3890 6466771
SGTC_322 k048-0136 19.3 µM -0.847898236230473 0.228342588217603 no 2643 0.198247323453762 3961 6823282
SGTC_2876 9059903 25.97 µM -0.848262764917089 0.228241460989257 no 2644 0.198145824707415 3830 6916095
SGTC_2221 6807166 181.081 µM -0.848290527086435 0.228233760264461 no 2645 0.19813809594219 3827 674925
SGTC_391 gliotoxin 8.33 µM -0.848855568142058 0.228077059813448 no 2646 0.197980832598608 4001 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1552 6-methylflavone 10.6 µM -0.850723067215404 0.227559584854036 no 2647 0.197461603138564 3824 689013
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.851608124532836 0.227314570852702 no 2648 0.197215814387776 3933 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2181 6316240 54.2555 µM -0.851677574242959 0.227295351099841 no 2649 0.197196535384499 3935 12779990
SGTC_218 alverine citrate 93.75 µM -0.852666117051087 0.227021877644684 no 2650 0.196922242906177 3932 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1081 sertraline 6 µM -0.853370556831654 0.226827112571586 no 2651 0.196726921943283 3908 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1556 plumbagin 1.48 µM -0.853473266473334 0.226798723058085 no 2652 0.196698453307525 3810 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_564 3555-0129 330 µM -0.853981304297693 0.226658328076404 no 2653 0.196557674174868 3775 563260
SGTC_1742 st038235 28.8875 µM -0.854151641906695 0.226611266686478 no 2654 0.196510486671461 3955 564103 YBR002C RER2
SGTC_571 k831-0106 44.2 µM -0.854220074110802 0.226592361583221 no 2655 0.196491531282654 3809 4783639
SGTC_1230 0170-0365 3.77 µM -0.855585084791679 0.226215449322133 no 2656 0.196113661453826 3983 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_121 0557-0495 61.343 µM -0.856542676366425 0.225951246827115 no 2657 0.195848838864202 4047 3104427
SGTC_1781 st038725 66.3 µM -0.85928944416158 0.225194373762584 no 2658 0.19509042323962 3905 4270275 YIL048W NEO1
SGTC_2627 acetyl isogambogic acid 100 µM -0.859539217849688 0.225125619820511 no 2659 0.195021546382533 3930 6857789 A caspase activator and apoptosis inducer.
SGTC_906 1165-0455 526 µM -0.861410813464931 0.22461081372705 no 2660 0.194505911244349 3889 3252859
SGTC_1651 st011928 86.1 µM -0.861582912832942 0.224563509165379 no 2661 0.194458538593548 3931 720198
SGTC_1443 4112-3303 14 µM -0.864587674097218 0.223738508636169 no 2662 0.193632570077536 3938 704433
SGTC_2066 5222451 176 µM -0.864932327133517 0.223643989455476 no 2663 0.193537966550853 3894 2281147
SGTC_1480 1070-0044 41.2 µM -0.865944975336037 0.223366407713355 no 2664 0.193260168729532 3934 3124987
SGTC_1252 0493-0875 34.8 µM -0.867501561562082 0.222940107096297 no 2665 0.192833628274748 3905 3960963
SGTC_1727 st034309 9.9045 µM -0.867825190864183 0.222851533313352 no 2666 0.192745018663577 4044 870305
SGTC_497 capsazepine 133 µM -0.86925732132366 0.222459815706925 no 2667 0.192353200471926 3915 2733484 A calcium channel blocker.
SGTC_2095 5432005 200 µM -0.869311431036096 0.2224450232724 no 2668 0.192338406090126 3934 783734
SGTC_979 1426-2828 121 µM -0.872178165546636 0.221662122120294 no 2669 0.191555594538762 4043 747872
SGTC_1728 st035614 33.7865 µM -0.87224262069024 0.221644537628975 no 2670 0.191538016408763 3926 15945546
SGTC_2971 9092186 9.93 µM -0.873104731974084 0.221409415230708 no 2671 0.191302997458891 3964 25236400
SGTC_1234 0326-0494 15.5 µM -0.873230057945573 0.221375247131369 no 2672 0.191268847242185 4010 1547813
SGTC_714 4296-0578 26.1 µM -0.874075074722088 0.221144945689177 no 2673 0.191038685212578 3968 1589775
SGTC_2961 9083290 32.55 µM -0.87456321433537 0.221011970278559 no 2674 0.190905805282522 3871 17741490
SGTC_3281 9140613 49.47 µM -0.875529569350619 0.220748857955165 no 2675 0.190642914244811 3955 16013766
SGTC_3124 9127567 49.47 µM -0.87642578861355 0.220505002110095 no 2676 0.190399301925096 3937 17592030
SGTC_1650 st011916 45.8 µM -0.87647374298802 0.220491958366927 no 2677 0.190386272250755 3861 242528
SGTC_830 4076-0286 57.8 µM -0.877178626386375 0.220300278852953 no 2678 0.190194811701237 4005 6866659
SGTC_2329 6138490 200 µM -0.878470304069633 0.219949279940742 no 2679 0.189844273133406 4076 720019
SGTC_2852 9023854 51.95 µM -0.878647043700319 0.219901277900698 no 2680 0.189796340026574 4034 19798528
SGTC_624 k048-0052 28 µM -0.878760651552798 0.219870425467716 no 2681 0.189765532658992 3929 6835531
SGTC_957 1187-1561 14.1 µM -0.879693845469945 0.219617092451765 no 2682 0.189512592179241 3897 1538454
SGTC_402 epigallocatechin gallate 10 µM -0.880713043929077 0.219340603494987 no 2683 0.189236577464661 3898 65064 An antioxidant.
SGTC_2 0422-0095 29 µM -0.882534255376986 0.218847042236637 no 2684 0.188743981893179 3817 6790840
SGTC_1923 st058458 19.1 µM -0.883578742888124 0.218564267256749 no 2685 0.188461829115066 3988 3534982
SGTC_1861 st057647 17.4 µM -0.884902958157646 0.218206063943613 no 2686 0.188104486215583 4049 688668
SGTC_2360 9040895 200 µM -0.885924501345972 0.217929965427327 no 2687 0.187829106091207 3991 4914414
SGTC_1445 4239-0156 97.7 µM -0.888978543888913 0.217105733703085 no 2688 0.187007305564261 4061 4008346
SGTC_2715 st079500 56.4 µM -0.890432558367747 0.216713954816263 no 2689 0.186616833245326 3903 28246688
SGTC_996 3970-0799 1.8 µM -0.89043894474961 0.21671223493137 no 2690 0.186615119311105 3988 6615648 YGL040C HEM2
SGTC_247 mechlorethamine 29.705 µM -0.890503804728588 0.21669476825862 no 2691 0.186597713178217 3854 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1596 piperlongumine 63 µM -0.890875820653065 0.216594600785059 no 2692 0.186497896632784 3993 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2074 5212007 75.395 µM -0.891999544006068 0.216292194373461 no 2693 0.18619658840355 3798 758611
SGTC_2842 9000675 19.48 µM -0.894431953953006 0.215638443716328 no 2694 0.185545411059873 4024 2989072
SGTC_896 0964-0007 44.5 µM -0.8947040397228 0.215565387451769 no 2695 0.185472659317027 3902 6756758
SGTC_2870 9038528 12.99 µM -0.896576889602385 0.215062908336173 no 2696 0.184972367247751 4035 6463316
SGTC_1547 harmine 94.2 µM -0.897044289989914 0.214937612556362 no 2697 0.184847642025054 3955 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2646 retinol 96.75 µM -0.897675858405683 0.214768375704349 no 2698 0.184679191820092 3970 445354 A vitamin A analog and teratogen.
SGTC_1330 1469-0054 61.8 µM -0.89802605438759 0.214674569579314 no 2699 0.184585829649077 3981 7102664
SGTC_2868 9035608 32.47 µM -0.898686827410183 0.214497634822923 no 2700 0.184409747663832 3932 6462614
SGTC_3120 9124077 49.47 µM -0.89934558179745 0.214321325021565 no 2701 0.18423430765489 4054 18774327 YGL155W CDC43
SGTC_1749 st037932 54.2 µM -0.900430222120653 0.214031214331015 no 2702 0.183945671749446 4034 594497
SGTC_1180 1193-0155 285 µM -0.901191182552422 0.213827815384337 no 2703 0.183743339152484 4043 2921347
SGTC_2772 vinpocetine 57.06 µM -0.905320544301541 0.212726032756142 no 2704 0.182647797814787 3977 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3341 9147222 25.867 µM -0.906291543107721 0.212467436232556 no 2705 0.182390780256138 3985 1939759
SGTC_2015 5119600 184 µM -0.909839348918159 0.211524146868525 no 2706 0.181453619757486 4035 2828786
SGTC_2834 9001755 58.44 µM -0.912690505887782 0.21076786245906 no 2707 0.180702669307756 3917 2989575
SGTC_1264 0783-0040 158 µM -0.912778527335707 0.210744539572274 no 2708 0.180679516875756 3880 2855798
SGTC_1103 duloxetine 36.1 µM -0.917039879272646 0.209617228546279 no 2709 0.179560871592813 4079 60835 A selective serotonin reuptake inhibitor.
SGTC_2686 alizarin 95.37 µM -0.9187645550691 0.209161987599668 no 2710 0.179109367889596 4007 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_60 0986-0278 202 µM -0.92104712434038 0.208560382389754 no 2711 0.178512912162697 3947 3110598
SGTC_2662 daunorubicin 22.37 µM -0.922442983009957 0.208192986235316 no 2712 0.178148779040449 3884 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3110 9122132 49.47 µM -0.923372151118081 0.207948636953731 no 2713 0.177906649723441 4104 918317
SGTC_1374 2889-5571 141 µM -0.924781461906715 0.207578344830402 no 2714 0.177539797706179 4044 2853281
SGTC_554 4483-2211 187 µM -0.924978936045796 0.207526490242575 no 2715 0.177488432171822 4043 747107
SGTC_860 0443-0016 25.1 µM -0.925748044023262 0.207324603733041 no 2716 0.17728846683385 4022 5337942
SGTC_2427 5545055 42.75 µM -0.926206807097231 0.207204236323983 no 2717 0.177169257832401 3973 5372858
SGTC_2359 9039622 200 µM -0.927146671022128 0.206957769770273 no 2718 0.176925193541893 3961 6463596
SGTC_2998 9066762 71.4286 µM -0.92723991732577 0.20693332665679 no 2719 0.176900990890644 4037 4945196
SGTC_2188 6126565 140.678 µM -0.928144649393087 0.206696253498482 no 2720 0.176666270772581 3921 874518
SGTC_3157 9099274 49.47 µM -0.928235604760427 0.206672428738886 no 2721 0.176642684569446 3996 17217662
SGTC_2597 laccaic acid a 100 µM -0.92910428458484 0.206444969541285 no 2722 0.176417522118618 4036 5491415 A textile dye.
SGTC_2956 9076196 2.52 µM -0.929185804997602 0.206423631469426 no 2723 0.176396401290634 4020 16423868
SGTC_1044 1222-0021 1.78 µM -0.929288752206313 0.206396686773637 no 2724 0.176369731357613 3975 4306703
SGTC_3239 9133757 49.47 µM -0.930206344033922 0.20615661467288 no 2725 0.176132128914492 4009 17036923
SGTC_657 3534-0529 86.7 µM -0.931702752967012 0.205765460376819 no 2726 0.175745081679105 4068 1049549
SGTC_1185 1319-0113 81.3 µM -0.933171057039592 0.205382080962173 no 2727 0.175365827936812 4078 4672763
SGTC_332 4112-0506 40.9 µM -0.934376986387994 0.205067526057145 no 2728 0.175054732327809 3977 2790355
SGTC_3204 9114183 49.47 µM -0.937841813749196 0.20416535427211 no 2729 0.17416285456387 4018 17027248
SGTC_689 0833-0039 98 µM -0.940668001940165 0.203431224822865 no 2730 0.173437510806657 3981 5374726
SGTC_2914 7968218 45.32 µM -0.941459185863393 0.20322598971178 no 2731 0.173234797726593 3981 2977111
SGTC_1451 4152-0210 104 µM -0.943012581408605 0.202823394675837 no 2732 0.172837233811632 4035 659563
SGTC_3074 9116018 49.47 µM -0.94307980003057 0.202805984321806 no 2733 0.172820043538134 4079 17027303
SGTC_1203 3992-3522 103 µM -0.944203071632401 0.202515176909073 no 2734 0.172532942942828 4170 5322312
SGTC_1717 st033143 58.0435 µM -0.944343207980407 0.202478914056038 no 2735 0.172497146395393 4080 674616
SGTC_164 4100-3994 89.624 µM -0.944624200482535 0.202406213784509 no 2736 0.172425383704265 3959 4615967
SGTC_2048 5246248 200 µM -0.945677742382453 0.202133773340823 no 2737 0.172156489156494 4030 677046
SGTC_2771 fluoxetine 41.05 µM -0.947592745127142 0.201639125862739 no 2738 0.171668410466211 4018 3386 A selective serotonin reuptake inhibitor.
SGTC_2076 5212012 200 µM -0.948703250553061 0.201352613449531 no 2739 0.171385780167666 3968 604802
SGTC_1578 josamycin 24.2 µM -0.949085971706163 0.201253927267888 no 2740 0.171288444291436 4041 5282165 A P450 substrate.
SGTC_1253 0550-0034 176 µM -0.949198792730787 0.201224841450051 no 2741 0.171259757736437 4063 5969915
SGTC_2225 6654152 15.4 µM -0.949236316756261 0.201215168129365 no 2742 0.171250217331881 3904 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1339 1486-1321 22.7 µM -0.951611226229241 0.200603507492843 no 2743 0.170647092996301 4041 3469382
SGTC_2284 7945075 39.21 µM -0.952055808037735 0.20048912912291 no 2744 0.170534339720911 4049 1245402
SGTC_1056 3448-1962 115 µM -0.952359005210172 0.200411147503868 no 2745 0.170457471286088 4037 715507
SGTC_2162 5663267 200 µM -0.953457929053138 0.200128659532998 no 2746 0.170179051264042 4010 6456493
SGTC_2528 xanthyletin 44.79 µM -0.954505814706153 0.199859514415302 no 2747 0.169913833694586 4074 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1235 benzylparaben 21.5 µM -0.95475479451758 0.19979559699718 no 2748 0.169850856430616 4045 7180
SGTC_676 falcarinol 140 µM -0.955015122268384 0.199728779518025 no 2749 0.169785024812471 4008 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2988 9073640 71.4286 µM -0.956269848074956 0.199406921705117 no 2750 0.169467959581625 4113 9102229
SGTC_2693 st077581 40.7 µM -0.956597992837899 0.199322798713349 no 2751 0.169385101158509 4089 25238761
SGTC_3344 9148862 3.898 µM -0.957404034782679 0.199116253025567 no 2752 0.16918168136825 4093 4905352
SGTC_2754 granisetron 64.02 µM -0.957423287041143 0.199111321272648 no 2753 0.169176824618762 4051 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2223 6903751 107.57 µM -0.957957248207628 0.198974568487933 no 2754 0.169042158401 4000 5598863
SGTC_1814 st052110 31.539 µM -0.958155793156079 0.198923733584149 no 2755 0.168992102478357 3987 674163
SGTC_1176 0848-0131 83.3 µM -0.959182359584509 0.198661019220538 no 2756 0.168733442800609 4073 6769040
SGTC_2897 9048598 12.99 µM -0.959974289015935 0.198458495161065 no 2757 0.16853407757033 4023 6467404
SGTC_350 k064-0020 19.8 µM -0.960447623779404 0.198337506400998 no 2758 0.168414989678296 4064 2790705
SGTC_1410 3909-8106 77.9 µM -0.962210551756895 0.197887277420669 no 2759 0.167971924903084 4094 1039210
SGTC_678 1218-2179 85.9 µM -0.964150719537971 0.197392497971316 no 2760 0.167485183627429 4025 6820081 YOR116C RPO31
SGTC_3330 9141424 71.43 µM -0.964273719789829 0.197361155821653 no 2761 0.167454356493698 4125 27261020
SGTC_989 1501-0895 10.3 µM -0.964991430085277 0.197178333430582 no 2762 0.167274552117251 4008 2830112
SGTC_1314 1222-0010 41.1 µM -0.966780307954506 0.196723098650792 no 2763 0.166826935314485 4062 3526027
SGTC_3088 9117578 49.47 µM -0.966833591879306 0.196709548693723 no 2764 0.166813614360077 4088 678341
SGTC_1179 1021-1431 9.29 µM -0.968370851402546 0.19631887123001 no 2765 0.166429595751728 4089 2840958
SGTC_2926 9010726 65.15 µM -0.968566449971207 0.196269195776041 no 2766 0.166380774771513 4101 2994293
SGTC_104 0074-0074 590.992 µM -0.969255806066419 0.196094183292268 no 2767 0.166208786713348 3837 3943124
SGTC_3072 9116419 49.47 µM -0.970909338475129 0.195674773440712 no 2768 0.165796713723342 4097 17170162
SGTC_1706 st031321 9.9705 µM -0.971733240162431 0.195465998510775 no 2769 0.16559163782367 4068 6103185
SGTC_2622 2-methoxyxanthone 59.94 µM -0.971854068604199 0.195435392220621 no 2770 0.165561576430899 4069 71034 A hepatoprotective.
SGTC_1555 citronellol 128 µM -0.972799010307767 0.195196135411369 no 2771 0.165326602341228 4016 8842 A terpine precursor.
SGTC_320 4092-0846 5.34 µM -0.975783339243676 0.194441680594936 no 2772 0.164585921373434 4037 1359356
SGTC_3308 9128332 17.569 µM -0.976028109025339 0.194379880308908 no 2773 0.164525267495216 4083 17332805 YDL196W YDL196W
SGTC_403 arphamenine a 50 µM -0.976338108834991 0.194301627694771 no 2774 0.164448470430546 4023 5487158 An arginine aminopeptidase inhibitor.
SGTC_1093 fluphenazine 7.97 µM -0.97643150584436 0.194278055440628 no 2775 0.164425337500492 4058 6602611 An atypical antipsychotic.
SGTC_2616 abietic acid 100 µM -0.977449362897434 0.194021273783646 no 2776 0.164173367527266 4091 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2902 5787006 60.46 µM -0.978583311058592 0.193735448682498 no 2777 0.16389295431967 4025 591003
SGTC_1830 st055982 50.3 µM -0.980821569758163 0.193172022960353 no 2778 0.16334036974455 3985 455313 An antimicrobial agent.
SGTC_612 0302-0167 22.4 µM -0.981089288439829 0.193104698507472 no 2779 0.163274356102152 4082 235821
SGTC_2075 5212009 200 µM -0.9812649440199 0.193060533371787 no 2780 0.163231052650513 3969 780898
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.981328264066071 0.193044614305868 no 2781 0.16321544452073 4000 1241132 A phosphatase inhibitor.
SGTC_712 r015-0009 80.6 µM -0.981709910457135 0.192948682928898 no 2782 0.163121390800645 4092 6813872 YLR060W FRS1
SGTC_2824 7998404 51.95 µM -0.981761991868814 0.192935593902303 no 2783 0.16310855848266 4024 837851
SGTC_489 paxilline 115 µM -0.982008127716961 0.192873742727468 no 2784 0.163047922048079 4066 105008 A toxic potassium channel blocker.
SGTC_1971 st069429 63.5 µM -0.98320040680434 0.192574307846168 no 2785 0.162754407312133 4040 1246522 YGL099W LSG1
SGTC_21 0849-0113 22.993 µM -0.983981112820404 0.192378391498137 no 2786 0.162562399754551 4025 1560156
SGTC_2719 novobiocin 32.65 µM -0.98479174547753 0.192175094159206 no 2787 0.162363188041081 4078 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1139 k015-0024 46.9 µM -0.985853975588087 0.19190889810868 no 2788 0.162102387279396 4104 2766652
SGTC_2115 tiliquinol 12.7705 µM -0.986919135462654 0.191642194619001 no 2789 0.1618411412954 4056 71208 A bioactive hydroxyquinoline.
SGTC_46 0329-0187a 2.197 µM -0.988705415847107 0.191195440924766 no 2790 0.161403646129267 4132 46494817
SGTC_1304 1165-0502 251 µM -0.991755628746007 0.190434051692695 no 2791 0.160658373657301 4086 767425
SGTC_1946 st076057 65.1 µM -0.994039427491413 0.189865194292376 no 2792 0.16010183637375 4024 953009
SGTC_1453 4237-0541 195 µM -0.995140625376891 0.189591277415185 no 2793 0.159833937208947 4076 739892
SGTC_1921 5740136 50 µM -0.996540533265212 0.189243409268309 no 2794 0.159493791542771 4034 1774243
SGTC_750 4073-0104 132 µM -0.99659310013715 0.189230354397021 no 2795 0.159481028229985 3853 22330957
SGTC_1138 3761-0006 1.03 µM -0.996838223401925 0.189169485875047 no 2796 0.159421520773895 4101 12061087
SGTC_1125 tnp00248 1.32998 µM -0.997568572193855 0.188988198602727 no 2797 0.159244303524867 4188 24207736
SGTC_2022 5136654 200 µM -0.99764024615773 0.188970413450707 no 2798 0.159226918977245 4146 1713771
SGTC_1855 st056195 39.6 µM -0.998591488489951 0.188734470174763 no 2799 0.158996312505383 4042 4028379
SGTC_3039 9090270 49.47 µM -0.999542763563086 0.188498700448284 no 2800 0.158765917057197 4098 17173750
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.00058683180961 0.188240141471706 no 2801 0.158513299477231 4074 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_493 zm226600 134 µM -1.00154435904712 0.188003206474744 no 2802 0.158281852809311 4135 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1735 st034310 56.75 µM -1.00298108849227 0.187648040995541 no 2803 0.157934992970972 4161 871153
SGTC_1345 1488-0192 31.4 µM -1.00353285879258 0.18751175132718 no 2804 0.157801915555999 4145 658348
SGTC_2653 dihydrofissinolide 100 µM -1.00361688180767 0.187491002644587 no 2805 0.157781657126935 4132 6857746
SGTC_208 k072-0098 12.366 µM -1.00384256999761 0.187435278121963 no 2806 0.157727250871241 4066 5948901
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.00431127320967 0.187319583629342 no 2807 0.157614300786558 4067 15053
SGTC_2724 maprotiline 69.64 µM -1.00672835659113 0.186723653012448 no 2808 0.15703266567302 4014 4011 A tricyclic antidepressant.
SGTC_2821 7996764 71.43 µM -1.00697422816918 0.186663099338405 no 2809 0.156973579551667 4159 2987135
SGTC_887 0885-0007 9.62 µM -1.00812118399522 0.186380785757694 no 2810 0.156698144492368 4174 5719458
SGTC_1992 st073643 23.3 µM -1.00851084914309 0.18628493316956 no 2811 0.156604641013067 4068 3161292
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.00871640987315 0.186234380196575 no 2812 0.156555329762871 4084 5106787 A p450 inhibitor.
SGTC_3091 9116372 49.47 µM -1.00907651247145 0.186145841669037 no 2813 0.156468970642643 4174 17169793
SGTC_410 α-linolenic acid 100 µM -1.00937072012589 0.186073524118009 no 2814 0.156398437610675 4166 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1999 st074831 12.5 µM -1.01032673776003 0.185838650996454 no 2815 0.156169387546957 4054 17112523
SGTC_3161 9100388 49.47 µM -1.01039454593209 0.185821998962559 no 2816 0.156153149941559 4157 25236368
SGTC_2911 7942208 15.64 µM -1.01114636113077 0.185637433496697 no 2817 0.155973191929065 4140 1243384
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.01214386022547 0.185392729962872 no 2818 0.155734636952379 3976 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2534 helenine 20.12 µM -1.01240875385599 0.185327780703604 no 2819 0.155671327277631 4095 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3196 9111891 49.47 µM -1.01318532790652 0.185137453973067 no 2820 0.155485823629751 4086 18891510
SGTC_1499 4480-0877 67.3 µM -1.01398497033074 0.184941600447782 no 2821 0.155294962002986 4037 2861909
SGTC_3343 9148379 18.9835 µM -1.01778000838689 0.18401385199755 no 2822 0.154391257357271 4148 1955036
SGTC_944 3370-0224 231 µM -1.02016742488636 0.18343170321468 no 2823 0.153824531972612 4149 4580514
SGTC_2731 amoxapine 43.43 µM -1.02022169069548 0.183418484372406 no 2824 0.15381166636903 4218 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.02117331862074 0.18318676975466 no 2825 0.153586165526786 4152 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2202 7226349 200 µM -1.02410905837875 0.182473089160938 no 2826 0.152891883170945 4066 844334
SGTC_1874 staurosporine 7.6 µM -1.02450056104636 0.182378045986544 no 2827 0.152799452983918 4158 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1019 4262-0212 3.4 µM -1.02499070302988 0.182259100240223 no 2828 0.152683787209933 4134 4677213
SGTC_547 1120-0019 610 nM -1.02521238988497 0.182205318064148 no 2829 0.152631491690337 4073 3676939
SGTC_329 k048-0121 21.3 µM -1.02544025225394 0.182150048020723 no 2830 0.152577751763789 4143 6832902
SGTC_1980 st071811 45.7 µM -1.0256658867088 0.182095328705547 no 2831 0.152524549648792 4210 4974850
SGTC_2453 5731132 22.18 µM -1.0258029592193 0.182062091841888 no 2832 0.152492235474284 4167 1362040
SGTC_1119 parthenolide 318.541 nM -1.02663900222133 0.181859453178487 no 2833 0.152295240785617 4238 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3356 9151811 4.48 µM -1.02693484432132 0.18178778128398 no 2834 0.152225572748117 4114 1859254 YPR165W RHO1
SGTC_1568 digitonin 820 nM -1.0279376680264 0.181544964676499 no 2835 0.151989574626968 4122 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_532 1548-0774 215 µM -1.02916615038668 0.18124778547938 no 2836 0.151700802817795 4240 5932993
SGTC_2532 xanthone 78.9 µM -1.03097402780415 0.180811000661538 no 2837 0.151276499734287 4126 7020 An insecticide.
SGTC_3135 9127742 49.47 µM -1.03317292271299 0.180280635802787 no 2838 0.150761491005437 4218 3643468
SGTC_717 1532-0246 73.2 µM -1.03391363974169 0.180102197797253 no 2839 0.150588268957422 4115 9561992
SGTC_1607 st000305 50.6 µM -1.03498268848406 0.179844860567856 no 2840 0.150338497963379 4146 5457690
SGTC_627 1391-0720 175 µM -1.0351353732249 0.179808125752218 no 2841 0.150302847464291 4112 997839
SGTC_1796 st049173 110.4 µM -1.03532701944269 0.179762023765856 no 2842 0.150258107788542 4088 94134
SGTC_2848 9016370 25.97 µM -1.03584382595139 0.179637738963203 no 2843 0.150137503911662 4118 7894410
SGTC_758 0868-0029 16 µM -1.0416571813793 0.178243429399553 no 2844 0.148785323777483 4157 762687
SGTC_737 1950-0117 57.9 µM -1.0427072396309 0.177992306395633 no 2845 0.148541951930035 4118 5393513
SGTC_1892 st058411 7.36 µM -1.04866627484733 0.176571422770429 no 2846 0.147165870661118 4156 3934738
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.05028019333453 0.176187834877278 no 2847 0.146794654407283 4210 165506
SGTC_1734 st037168 69.4 µM -1.05053902101482 0.176126367148668 no 2848 0.146735180135688 4195 708907
SGTC_306 1672-3436 11.6 µM -1.05071561147322 0.176084437329593 no 2849 0.146694611881451 4195 6797378
SGTC_1454 4239-0054 42.6 µM -1.0521801042355 0.175736950216776 no 2850 0.146358462919292 4254 1340767
SGTC_778 3456-2434 196 µM -1.05302091123141 0.175537644413023 no 2851 0.14616570411366 4102 5539063
SGTC_1949 st076024 69.1 µM -1.05649787676072 0.174714982600995 no 2852 0.145370405187363 4080 2921930
SGTC_1863 st057641 20.1 µM -1.05729466136364 0.174526805939274 no 2853 0.14518856449437 4164 3921635
SGTC_1490 4089-0339 670 nM -1.06024774290876 0.173830499644181 no 2854 0.144515953074928 4114 742542
SGTC_83 0170-0301 39.027 µM -1.06162478964743 0.17350641105636 no 2855 0.144203027608203 4159 3089716
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.06275869031792 0.173239835896238 no 2856 0.143945698789909 4156 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.06336790375895 0.173096720203448 no 2857 0.143807571124903 4135 140250 A respiratory chain inhibitor.
SGTC_1288 0973-0013 65.5 µM -1.06349610291823 0.173066613404165 no 2858 0.143778515774641 4193 4315430
SGTC_1686 st019653 115.5 µM -1.06388185450932 0.172976042090542 no 2859 0.143691112044405 4136 97252
SGTC_2462 5162487 171.77 µM -1.0684379137151 0.171908602148492 no 2860 0.142661511221648 4055 2259986
SGTC_919 tnp00227 403.569 nM -1.06858477063449 0.171874265132592 no 2861 0.142628406960886 4126 1269246 A methoxyflavone. YNL221C POP1
SGTC_2606 farnesol 9.78 µM -1.07145766135742 0.171203427727848 no 2862 0.141981849006372 4209 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2418 pentamidine 31.67 µM -1.07540232687453 0.170285056015256 no 2863 0.141097320242917 4123 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1306 1185-0270 9.02 µM -1.07642739413333 0.170046924004612 no 2864 0.140868078157227 4204 1548076
SGTC_827 3253-0474 693 µM -1.07718913835682 0.169870102525373 no 2865 0.140697888357345 4220 5402065
SGTC_484 loperamide 105 µM -1.08075334433618 0.169044320715387 no 2866 0.1399034235694 4180 3955 An opioid-receptor agonist.
SGTC_1327 1436-0082 2.18 µM -1.08134760506262 0.168906889144627 no 2867 0.139771259439133 4180 15992205
SGTC_2342 7990637 118.86 µM -1.0817630501109 0.168810853983263 no 2868 0.139678914504469 4219 2033102 YER133W GLC7
SGTC_2959 9079155 11 µM -1.08257238287182 0.168623867672032 no 2869 0.139499135535817 4216 16189457
SGTC_3171 9103192 49.47 µM -1.08333574974163 0.168447623265838 no 2870 0.139329711364936 4238 13018434
SGTC_160 3453-0671 289.699 µM -1.08544021818182 0.167962362019638 no 2871 0.13886336387578 4221 5322268
SGTC_147 4466-0538 29.23 µM -1.0874553112169 0.167498553641049 no 2872 0.138417819090862 4290 6742687 YHR072W ERG7
SGTC_490 phenamil 164 µM -1.08991343048948 0.166933893433784 no 2873 0.137875639932691 4147 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2384 9036245 200 µM -1.09070607061237 0.166752076341939 no 2874 0.13770111927846 4110 6462766
SGTC_48 0382-0018 55 µM -1.09131416106733 0.166612678200168 no 2875 0.13756733433933 4246 762596
SGTC_2154 5570129 200 µM -1.09287465895145 0.166255295242761 no 2876 0.137224417971464 4231 673366
SGTC_1833 st055984 71 µM -1.09377045419126 0.166050365369887 no 2877 0.137027832712153 4187 676288
SGTC_1498 4478-3555 97.6 µM -1.09701616565166 0.165309216002749 no 2878 0.13631716273412 4168 3437919
SGTC_1621 st003705 32.4 µM -1.09932308621058 0.164783740438038 no 2879 0.13581358299383 4188 24207032
SGTC_1844 rapamycin 4 nM -1.10068549754364 0.164473916070512 no 2880 0.13551678011532 4089 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1197 1601-0112 267 µM -1.10187944786496 0.164202711863452 no 2881 0.135257042325033 4157 7350313
SGTC_3158 9100007 49.47 µM -1.10331685290743 0.163876592217911 no 2882 0.13494479522619 4219 19297233
SGTC_1109 tnp00067 928.257 nM -1.1065910096046 0.16313531909354 no 2883 0.134235398031224 4196 676295
SGTC_1976 st070609 63.5 µM -1.11253892732064 0.161794287274412 no 2884 0.132953251318442 4135 682556
SGTC_2376 9072922 81.32 µM -1.11475929459835 0.161295524497145 no 2885 0.132476792046269 4219 17087968
SGTC_2032 5185112 25.99 µM -1.11592850666881 0.161033287041369 no 2886 0.132226369211251 4096 5718189
SGTC_3134 9127454 49.47 µM -1.11636429899309 0.160935616310069 no 2887 0.132133114378597 4262 24262820
SGTC_469 w7 172 µM -1.11707140633446 0.160777220153042 no 2888 0.131981897578152 4282 45115570 A P450 inhibitor.
SGTC_1652 st011932 78 µM -1.11815228951537 0.160535292825965 no 2889 0.131750978554143 4155 1551076
SGTC_3242 9133940 49.47 µM -1.11843315683901 0.160472466994618 no 2890 0.131691019939983 4229 17248444
SGTC_1643 st009866 20.2 µM -1.1192250328722 0.160295422638132 no 2891 0.131522074291358 4159 3156273 YOR207C RET1
SGTC_2595 hexamethylquercetagetin 100 µM -1.11922608151789 0.160295188270952 no 2892 0.131521850663496 4201 386331
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.12266465025372 0.159527889382869 no 2893 0.130789973320914 4204 641818 YHR062C RPP1
SGTC_3276 9139060 49.47 µM -1.12680585250513 0.158606997930095 no 2894 0.129912287770122 4316 4870619
SGTC_2323 6148992 148.28 µM -1.13008293930462 0.157880738032953 no 2895 0.129220638945707 4202 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2397 5161689 200 µM -1.13127498228714 0.157617102915533 no 2896 0.128969685377896 4296 2259942
SGTC_2191 5911152 200 µM -1.13632363176158 0.156503739762594 no 2897 0.127910572010325 4224 2875902
SGTC_620 0109-0052 432 µM -1.13996348130022 0.155704275193282 no 2898 0.127150757850794 4245 493037
SGTC_1351 1496-0003 46.5 µM -1.14075618355511 0.155530522093352 no 2899 0.126985699527597 4252 3891978
SGTC_1084 voriconazole 435 nM -1.1420055824605 0.155256925031703 no 2900 0.126725849625316 4238 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1908 st060353 56.5 µM -1.14630581432883 0.154317677260213 no 2901 0.125834318993155 4288 4227716
SGTC_1071 trifluoperazine 6.31 µM -1.14855672996863 0.153827538115407 no 2902 0.125369403973751 4309 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3329 9141233 27.5565 µM -1.14859208944677 0.153819846782835 no 2903 0.125362110234387 4201 4909101 YNL103W MET4
SGTC_515 4092-1064 102 µM -1.15018046406899 0.153474608810487 no 2904 0.12503477539648 4251 717353
SGTC_3123 9126162 49.47 µM -1.1529891095049 0.152865398347553 no 2905 0.124457427278728 4298 25239884
SGTC_3083 9117465 49.47 µM -1.15342039376476 0.152771992665841 no 2906 0.124368937391392 4240 16420915
SGTC_1811 st050069 61.5 µM -1.15408571939999 0.152627973568119 no 2907 0.124232513755651 4217 3877702
SGTC_2921 7974240 10.71 µM -1.15931753531626 0.151498613048086 no 2908 0.123163388330901 4334 2979074 YDR527W RBA50
SGTC_789 1309-1135 70.6 µM -1.16003126934379 0.151344975379865 no 2909 0.123018037623063 4219 3092424
SGTC_2112 5488546 200 µM -1.16038519075478 0.151268829057522 no 2910 0.122946006752446 4205 600757
SGTC_2601 securinine 100 µM -1.16371237867571 0.150554229334408 no 2911 0.122270295598687 4234 442872 A GABA receptor antagonist.
SGTC_351 caspofungin 25 nM -1.16402562644126 0.150487067270883 no 2912 0.122206813344747 4252 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1700 st030840 7.9285 µM -1.16512052560356 0.150252471620526 no 2913 0.121985104766552 4304 5499307
SGTC_2242 6630449 61.2675 µM -1.166362718966 0.149986611643383 no 2914 0.121733912496603 4304 691249 YDR170C SEC7
SGTC_2853 9015042 58.44 µM -1.16746344182717 0.149751292115198 no 2915 0.121511631839203 4186 6457456
SGTC_2184 6075246 200 µM -1.16935711352426 0.149347027576984 no 2916 0.121129890539529 4254 2267320
SGTC_2930 9013230 14.89 µM -1.17665797889173 0.147795250001413 no 2917 0.119666023143969 4283 2995857
SGTC_362 0310-0100 9.03 µM -1.17884039747231 0.147333486844321 no 2918 0.11923086742141 4323 790235
SGTC_2234 tolnaftate 200 µM -1.17886098894192 0.147329134644205 no 2919 0.119226766983062 4336 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1767 st044992 70.3 µM -1.18014242188919 0.14705846129563 no 2920 0.118971787373915 4300 9600693
SGTC_2553 4-methylesculetin 85.09 µM -1.18243799675623 0.146574407887856 no 2921 0.118515977011026 4295 5319502
SGTC_1893 st059353 36.1 µM -1.18518632341444 0.145996293562975 no 2922 0.117971893093304 4284 3112488
SGTC_2036 5160441 105 µM -1.18651642176949 0.145717056409863 no 2923 0.117709210107633 4249 134534 YIL048W NEO1
SGTC_1565 sinapyl alcohol 95.1 µM -1.18802697882606 0.145400369929626 no 2924 0.117411390418311 4286 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3323 9138564 53.9225 µM -1.19051802310037 0.144879137385718 no 2925 0.116921425240949 4292 43912313 YNL103W MET4
SGTC_2482 5981709 142.65 µM -1.1957300279608 0.143792638330548 no 2926 0.115900964667629 4206 877755
SGTC_1429 4049-0205 9.46 µM -1.19584053718021 0.143769661156163 no 2927 0.115879396700792 4311 22774478
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.19904006070173 0.14310548750245 no 2928 0.115256184423189 4260 756377
SGTC_183 3914-0051 30.55 µM -1.20154764394783 0.142586401501556 no 2929 0.114769418364958 4317 1596232
SGTC_3339 9145883 14.936 µM -1.20376645418347 0.142128156406944 no 2930 0.114339929433281 4200 2030670
SGTC_2648 atorvastatin 78.68 µM -1.20510726645864 0.141851725618833 no 2931 0.114080947498315 4286 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1716 st033144 30.6155 µM -1.20653847776764 0.141557059532545 no 2932 0.113804966079584 4312 674617
SGTC_2173 5763948 167 µM -1.20735323181218 0.141389498620072 no 2933 0.113648069224874 4269 2867177
SGTC_1159 4092-0538 61.2 µM -1.20758883663465 0.141341069605229 no 2934 0.113602727656354 4324 717301
SGTC_1352 1496-0991 99 µM -1.20925333054394 0.140999250068722 no 2935 0.113282767281315 4285 3000039
SGTC_525 k781-2675 26.7 µM -1.21076139778149 0.140690038722801 no 2936 0.112993431833257 4252 3651118 YDL195W SEC31
SGTC_2560 caryophyllene 100 µM -1.21480765123779 0.139862677427794 no 2937 0.112219730986495 4337 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_92 0063-0024 660.874 µM -1.21761696983012 0.139290188409473 no 2938 0.111684781314567 4382 3594437
SGTC_3172 9105863 49.47 µM -1.21915621986487 0.138977193770243 no 2939 0.111392452526972 4370 2348785
SGTC_3005 9076496 71.4286 µM -1.22043364956019 0.138717802134146 no 2940 0.111150263882248 4269 21368410
SGTC_333 3486-0131 40.1 µM -1.22300387160577 0.138196899131822 no 2941 0.110664116997309 4344 6744690
SGTC_488 nitrendipine 139 µM -1.22463156558841 0.137867707449882 no 2942 0.110357034579 4338 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_851 0394-0702 453 µM -1.22545409587595 0.137701559099497 no 2943 0.11020208778119 4311 762646
SGTC_192 3455-0609 60.9 µM -1.23116127313889 0.136552492278499 no 2944 0.109131276224679 4376 3769639
SGTC_1883 5-benzylidenerhodanine 20 µM -1.23678375047373 0.135426907977252 no 2945 0.108083688151162 4294 1273210
SGTC_467 ro 31-8220 72.8 µM -1.2378379643003 0.135216570962589 no 2946 0.107888074217118 4265 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1141 3253-0389 52.6 µM -1.24282748881718 0.134224099063352 no 2947 0.106965705285728 4314 5402031
SGTC_3144 9087057 49.47 µM -1.24308351644556 0.134173307629599 no 2948 0.106918529646583 4235 17249618
SGTC_3300 9124615 50.48 µM -1.24400851394827 0.133989914216256 no 2949 0.106748214729287 4360 24824903
SGTC_2122 5258151 111.688 µM -1.2445839722086 0.133875908691112 no 2950 0.106642357467265 4326 2173356
SGTC_3264 9137442 49.47 µM -1.24661625320514 0.133473821804507 no 2951 0.106269119638846 4311 17015726
SGTC_3109 9122853 49.47 µM -1.24835002599592 0.133131451975556 no 2952 0.105951450765473 4352 1234709
SGTC_815 1582-0027 36.9 µM -1.24927410478487 0.132949220352109 no 2953 0.105782417921885 4354 3128206
SGTC_2986 9022445 71.43 µM -1.24943182605894 0.132918134320928 no 2954 0.105753586972593 4320 6459286
SGTC_3255 9139072 49.47 µM -1.24977759550776 0.13285000249871 no 2955 0.105690401290706 4326 17646060
SGTC_912 3474-0017 2.18 µM -1.25545035210936 0.131735652388958 no 2956 0.104657660201731 4361 3360550
SGTC_610 4215-0184 155 µM -1.25680450730862 0.131470599945556 no 2957 0.104412216764902 4338 5605015
SGTC_248 streptozotocin 5.23457 mM -1.25771871358173 0.131291868192136 no 2958 0.104246750996462 4367 5300 DNA alkylating agent.
SGTC_65 0798-0905 34.986 µM -1.26366856977714 0.130132742410477 no 2959 0.10317450537871 4391 3602145
SGTC_615 k087-0205 167 µM -1.26467073975073 0.129938202933236 no 2960 0.102994691567139 4364 9642773
SGTC_1309 pyrazolanthrone 13.4 µM -1.2653544031234 0.12980560697306 no 2961 0.102872156319209 4306 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2455 5377712 9.75 µM -1.26688210675476 0.129509648774887 no 2962 0.102598723816637 4326 2243908
SGTC_1981 st071826 47 µM -1.2688647383187 0.12912625605023 no 2963 0.102244655325412 4388 11838600
SGTC_1937 st074714 47.2 µM -1.26913616145764 0.129073830715901 no 2964 0.102196252441387 4290 17250970
SGTC_1034 k072-0165 12.7 µM -1.27078033446118 0.128756574450676 no 2965 0.101903403369462 4368 5835461
SGTC_3291 9121177 71.43 µM -1.27194619566854 0.128531940329006 no 2966 0.101696118391313 4333 17015612
SGTC_2894 9048625 32.47 µM -1.2757903238934 0.127793194597405 no 2967 0.101014824477007 4371 4092861
SGTC_217 ketoconazole 989 nM -1.27636302380691 0.127683389005201 no 2968 0.10091361043472 4167 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_824 1304-0008 100 µM -1.27684150018179 0.127591699495286 no 2969 0.100829105355513 4378 768245
SGTC_1114 scopoletin 1.73284 µM -1.27744420171933 0.127476270115882 no 2970 0.100722733964738 4368 5280460 A coumarin with genotoxic properties.
SGTC_1506 4226-2149 212 µM -1.27959894553967 0.127064187629639 no 2971 0.100343110453746 4351 991114
SGTC_1798 st045719 60.953 µM -1.28101820993693 0.126793268320786 no 2972 0.100093635012218 4302 3980186
SGTC_3185 9108267 49.47 µM -1.28459783419425 0.126111751362462 no 2973 0.0994664279564677 4356 4910486
SGTC_1919 st067113 52.3 µM -1.28811347528874 0.125444905691065 no 2974 0.0988532326182864 4363 1268243
SGTC_2409 alverine citrate 63.97 µM -1.29006367501765 0.1250760555383 no 2975 0.0985142753775972 4418 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_127 0180-0333 59.125 µM -1.29035855966145 0.125020348658376 no 2976 0.0984630966818154 4273 771601
SGTC_2522 biochanin a 4.94 µM -1.29099808846736 0.124899594345629 no 2977 0.0983521701757529 4369 5280373 A possible chelator.
SGTC_963 1269-2853 151 µM -1.29626982516985 0.123907301514072 no 2978 0.0974412703122843 4337 3668223
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.29672614540415 0.123821669098867 no 2979 0.0973627150157687 4318 688761
SGTC_2924 9010168 62.78 µM -1.29722683607919 0.123727757864125 no 2980 0.097276574836525 4392 2993929
SGTC_265 mycophenolic acid 32.932 µM -1.29878092235592 0.123436585840548 no 2981 0.0970095617824158 4417 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3008 9078912 71.4286 µM -1.29911278812826 0.12337447005268 no 2982 0.0969526125284188 4376 16648731
SGTC_1936 st074407 74.3 µM -1.30182371744918 0.122867881585159 no 2983 0.09648832705005 4396 809813
SGTC_228 caffeine 993.056 µM -1.30207035378102 0.12282186541031 no 2984 0.0964461682543967 4356 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2643 anethole 100 µM -1.3036844552769 0.122521012775113 no 2985 0.0961705958214806 4355 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2690 usnic acid 100 µM -1.30425889476384 0.122414067768145 no 2986 0.0960726626647444 4383 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1546 5-methoxyflavanone 78.7 µM -1.30463222852662 0.122344598310493 no 2987 0.0960090542871306 4384 147795
SGTC_3049 9092223 49.47 µM -1.30624326766423 0.122045135615827 no 2988 0.095734921568759 4353 8623917
SGTC_3312 9133330 71.43 µM -1.30659733540867 0.121979389956837 no 2989 0.0956747510367087 4385 17617324
SGTC_780 0109-0199 192 µM -1.31028570120336 0.121295988621423 no 2990 0.0950496014049804 4423 610414
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.31192963653031 0.1209922600395 no 2991 0.0947719384116575 4468 688664
SGTC_1722 st034304 3.6505 µM -1.31236752796662 0.120911446855291 no 2992 0.0946980788452482 4334 4036148 YLR033W RSC58
SGTC_1058 3448-5425 97.3 µM -1.31262192058916 0.120864515957747 no 2993 0.0946551896858333 4323 7279705
SGTC_2014 4013930 200 µM -1.31479570960822 0.12046401344749 no 2994 0.0942892848823145 4345 64556
SGTC_1335 1486-0900 202 µM -1.31676876455831 0.120101304493619 no 2995 0.0939580729350995 4373 X1335
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.31895998644294 0.119699392419705 no 2996 0.0935912449753962 4377 688751
SGTC_3033 9090887 49.47 µM -1.32362518026012 0.1188468682641 no 2997 0.0928137790966585 4398 19325384
SGTC_705 1124-0212 310 µM -1.32427641570186 0.118728202546537 no 2998 0.0927056301015353 4373 9554485
SGTC_2630 antimycin a 100 µM -1.32455031560849 0.11867831853099 no 2999 0.0926601721015239 4312 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3022 9087993 49.47 µM -1.3249140657281 0.118612093440713 no 3000 0.092599827533852 4461 17173644
SGTC_1928 4'-methoxychalcone 40.3 µM -1.32953529529285 0.117773015501336 no 3001 0.0918357146313727 4405 641818
SGTC_2885 9057732 51.95 µM -1.34038006094174 0.115820446872347 no 3002 0.0900609073678165 4423 6471414
SGTC_2798 7813637 45.45 µM -1.34110940437638 0.115689960625322 no 3003 0.0899424671916965 4382 956368
SGTC_878 0828-0289 13.7 µM -1.34663046613539 0.114705578287673 no 3004 0.0890496384735922 4349 745350 YLR208W SEC13
SGTC_2493 resveratrol 26.09 µM -1.34771554403436 0.114512816254636 no 3005 0.0888749453223088 4322 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2850 9015429 58.44 µM -1.3481657357968 0.114432908255981 no 3006 0.088802541208375 4393 6457570
SGTC_980 1473-0395 201 µM -1.3511776039865 0.113899329657978 no 3007 0.0883192734837714 4297 768876
SGTC_2417 cerulenin 830 nM -1.35875925795554 0.112564028523061 no 3008 0.08711144377258 4414 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2322 7413319 38.22 µM -1.36250312622953 0.111908788198033 no 3009 0.0865195791105653 4378 1840400
SGTC_3122 9126309 49.47 µM -1.36271503916615 0.111871781578276 no 3010 0.0864861681092557 4500 17591206
SGTC_1492 4158-0558 28.5 µM -1.36294523797246 0.111831591592163 no 3011 0.0864498850194841 4420 3967268
SGTC_3037 9091026 49.47 µM -1.37228343208943 0.110209950380571 no 3012 0.0849876106240769 4295 25236398 YIL048W NEO1
SGTC_823 0417-1665 178 µM -1.3737243320442 0.109961237959427 no 3013 0.0847636400048176 4424 3429856
SGTC_845 0330-0138 4.51 µM -1.37442759349694 0.109839995006247 no 3014 0.0846544873023334 4362 9039800
SGTC_1958 st076513 41.9 µM -1.37935872738821 0.108992557147727 no 3015 0.0838920889237508 4361 732122 YGL099W LSG1
SGTC_1238 0333-0287 48.8 µM -1.3813727775032 0.108647788622404 no 3016 0.08358218579187 4416 7226
SGTC_897 1000-0139 31.4 µM -1.38284193455266 0.10839679106344 no 3017 0.083356668856755 4393 6151020
SGTC_110 0850-0284 111.64 µM -1.38726466773066 0.107643710198921 no 3018 0.0826805363709124 4334 3906265
SGTC_835 0312-0010 67.2 µM -1.38987186717779 0.107201539301311 no 3019 0.0822838949191452 4447 1626196
SGTC_54 0159-0055 9 µM -1.39013359486833 0.107157223743908 no 3020 0.0822441567451416 4420 3319099
SGTC_1496 4469-0713 57.4 µM -1.39185780390306 0.106865611974139 no 3021 0.0819827308764306 4405 746691
SGTC_496 calpeptin 138 µM -1.39654364746733 0.106075998769944 no 3022 0.0812754232168016 4428 73364 A calpain inhibitor.
SGTC_3253 9135987 49.47 µM -1.39679158204736 0.106034336955091 no 3023 0.0812381272132571 4433 4182430
SGTC_2205 7238770 200 µM -1.39698496056809 0.106001850703585 no 3024 0.0812090468669171 4483 279867
SGTC_417 st075190 100 µM -1.39827251119189 0.105785734465519 no 3025 0.081015624651878 4421 222757
SGTC_1756 st041558 35.5 µM -1.39842706248573 0.105759814352938 no 3026 0.0809924305864645 4513 3955792
SGTC_2652 actinonin 100 µM -1.39852811915724 0.105742868415209 no 3027 0.0809772673606109 4486 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1487 3970-0795 2.82 µM -1.39949694896061 0.105580507402885 no 3028 0.0808320063170925 4483 3765103
SGTC_252 miconazole 1.30953 nM -1.39979849127282 0.105530010342158 no 3029 0.0807868348808504 4334 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2849 9019321 12.99 µM -1.40687677895479 0.10434967486379 no 3030 0.0797319651758121 4450 16489627
SGTC_868 0527-0199 213 µM -1.41097767815506 0.103670224490608 no 3031 0.0791255979806574 4410 2849450
SGTC_1484 3473-2379 286 µM -1.4132393452917 0.103296880224876 no 3032 0.0787926807356463 4559 671917
SGTC_1155 4088-0394 48.2 µM -1.41597067999072 0.102847308151648 no 3033 0.0783920445384793 4439 2326248
SGTC_1828 st055811 49 µM -1.41700126510311 0.102678045916052 no 3034 0.0782412787977397 4457 5877589
SGTC_1810 st050138 53 µM -1.42063873145617 0.102082250725338 no 3035 0.0777109062961041 4449 3444541
SGTC_1192 1488-0095 21.4 µM -1.42127366001293 0.101978511604254 no 3036 0.0776186089200804 4476 915875
SGTC_3345 9148410 3.559 µM -1.42188441062213 0.101878795258646 no 3037 0.0775299047666832 4388 4903596
SGTC_1995 st072814 61.1 µM -1.4238380533409 0.101560303518035 no 3038 0.077246678655862 4435 5769371
SGTC_3015 9080845 49.47 µM -1.43004158711009 0.100553782916936 no 3039 0.0763525417746512 4515 5296973
SGTC_220 paclitaxel 373.376 µM -1.43093686623368 0.100409127275185 no 3040 0.0762241550073533 4426 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1739 st037196 92.5 µM -1.43403620991029 0.099909520505125 no 3041 0.0757809649515928 4473 612214
SGTC_1677 st019204 53.9 µM -1.43424957528597 0.0998751934339247 no 3042 0.0757505271708154 4453 3945625
SGTC_2403 6032726 181.2 µM -1.43692381964908 0.0994456807546486 no 3043 0.0753698204419173 4465 2881040
SGTC_292 k038-0015 474 µM -1.43991387667528 0.0989670456255001 no 3044 0.0749458832923171 4450 46368540
SGTC_1263 0774-1208 64.8 µM -1.43995608869958 0.0989603005960048 no 3045 0.074939911421749 4461 906585
SGTC_2529 gangaleoidin 93.61 µM -1.44037911223869 0.0988927245354981 no 3046 0.0748800849675168 4455 4565183
SGTC_3180 9109287 49.47 µM -1.44244016371763 0.098563963999394 no 3047 0.0745891201541664 4489 18891271
SGTC_570 0987-0065 62.6 µM -1.44474303448571 0.0981975778430265 no 3048 0.074265038618488 4305 3104428
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.44664356487755 0.0978959561799645 no 3049 0.0739983890410667 4488 688788
SGTC_1619 st003326 88.7 µM -1.44954308179053 0.0974371004883949 no 3050 0.073592989081254 4446 2849032
SGTC_1747 st037496 66.6 µM -1.45162548621958 0.0971085295698311 no 3051 0.0733028841282616 4424 723305
SGTC_2675 theaflavin digallate 100 µM -1.45206961395766 0.0970385584780793 no 3052 0.0732411249227816 4396 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3227 9130768 49.47 µM -1.45233480952666 0.0969967953028594 no 3053 0.0732042665285177 4559 17720899
SGTC_1654 st012436 41.8 µM -1.4567393843326 0.0963050882406535 no 3054 0.0725941668849978 4462 4323132
SGTC_2932 9016711 44.54 µM -1.45822994814974 0.0960718288007123 no 3055 0.0723885858015363 4455 7117328
SGTC_2380 9035439 200 µM -1.46031265776408 0.0957466001234423 no 3056 0.0721020824233725 4523 6462575
SGTC_2306 7482397 179.52 µM -1.4658415864936 0.0948871523200951 no 3057 0.0713457243221582 4471 891448
SGTC_798 1287-0182 476 µM -1.46627055599645 0.0948207092611424 no 3058 0.071287296796938 4507 1649755
SGTC_2471 5466956 24.79 µM -1.46806380832572 0.094543323720972 no 3059 0.0710434456355307 4467 724419
SGTC_616 4092-0450 108 µM -1.4734143398245 0.0937192436690559 no 3060 0.0703196729862998 4482 787165
SGTC_2949 9072542 2.23 µM -1.47576008019659 0.0933596334023276 no 3061 0.0700041554159741 4456 16457352
SGTC_2677 mitomycin C 100 µM -1.47716887642913 0.0931441504859377 no 3062 0.0698151872117179 4558 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3023 9089636 49.47 µM -1.48242438834898 0.0923435347753036 no 3063 0.0691137043321454 4566 17249241
SGTC_1982 st072467 71.9 µM -1.48512923194139 0.0919334738964177 no 3064 0.0687547969416999 4471 3163533
SGTC_654 1124-0271 80.9 µM -1.48534546638915 0.09190075053234 no 3065 0.0687261668104678 4478 5403748
SGTC_138 0850-0259 40.9225 µM -1.48745280974094 0.0915822919572935 no 3066 0.0684476289902247 4429 6813004
SGTC_679 0422-0091 41.4 µM -1.48896632835602 0.091354076365654 no 3067 0.0682481178351796 4514 627384 YHR062C RPP1
SGTC_3222 9128301 49.47 µM -1.49014498208596 0.091176645504546 no 3068 0.0680930594582066 4452 4911358
SGTC_1853 st056710 91.2 µM -1.49226802006112 0.0908576949064049 no 3069 0.0678144484338184 4519 269167
SGTC_399 oxolinic acid 75 µM -1.50200126469911 0.0894060319147433 no 3070 0.0665483911047139 4460 4628 A DNA gyrase inhibitor.
SGTC_866 0495-0101 262 µM -1.50359563209313 0.0891698940085533 no 3071 0.0663427582479018 4508 635694
SGTC_2714 st079313 56.9 µM -1.51082424495351 0.088105101652451 no 3072 0.0654166179118491 4491 2939799
SGTC_873 0591-4978 488 µM -1.52058989644618 0.0866816894830758 no 3073 0.064181391924314 4527 3305145
SGTC_2060 5238662 140 µM -1.52207616495852 0.086466570924405 no 3074 0.0639949987289005 4472 790130
SGTC_3248 9135562 49.47 µM -1.52691163070037 0.0857694600912761 no 3075 0.0633914935240632 4504 17650701
SGTC_921 1561-0023 372 µM -1.53394775018594 0.0847626161012981 no 3076 0.0625212537252039 4486 24050882
SGTC_2354 9060492 162 µM -1.53488055711967 0.0846298028506642 no 3077 0.0624065851093548 4519 6471895
SGTC_190 3970-0790 3.722 µM -1.53895588994917 0.0840513862411694 no 3078 0.0619075326122814 4481 2832352
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.54138264800642 0.0837083665305002 no 3079 0.0616118423108319 4525 5024745
SGTC_1395 3486-0190 4.35 µM -1.54152815271624 0.0836878330593927 no 3080 0.0615941482763417 4494 6748079
SGTC_2490 carminic acid 95.39 µM -1.54157686100175 0.0836809602429772 no 3081 0.0615882260138681 4510 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2117 5521686 200 µM -1.55033822004541 0.0824516045656652 no 3082 0.0605301791906371 4511 803312
SGTC_43 0570-0105 72.5 µM -1.55522930231359 0.0817712497361515 no 3083 0.0599457339740154 4488 1114046 YDL195W SEC31
SGTC_2487 5918373 44.05 µM -1.55922297008057 0.0812188714670187 no 3084 0.0594718080070701 4582 2876279
SGTC_2037 5169046 200 µM -1.56012063966927 0.0810951000401192 no 3085 0.0593656874790751 4578 5718022
SGTC_10 0279-0212 42.575 µM -1.56225347555615 0.0808015938038795 no 3086 0.0591141437115716 4549 39851 YBR002C RER2
SGTC_3193 9111931 49.47 µM -1.56595888267677 0.0802935893181315 no 3087 0.0586791216960063 4522 17087244
SGTC_480 am 92016 50 µM -1.57199893877486 0.0794706879842642 no 3088 0.0579753986654785 4542 2129 K+ channel blocker.
SGTC_1059 3448-6867 171 µM -1.57215371501958 0.0794496853504921 no 3089 0.0579574533344562 4495 3934407
SGTC_3267 9137951 49.47 µM -1.57304943891546 0.0793282210207969 no 3090 0.0578536855179558 4556 16643986
SGTC_521 r062-0005 13.8 µM -1.57533570818406 0.0790188296026552 no 3091 0.0575894879234807 4468 2832033
SGTC_733 4069-0007 56.1 µM -1.57924165343178 0.0784923697898028 no 3092 0.0571403195944324 4536 5717425 YNL287W SEC21
SGTC_295 k015-0027 31 µM -1.58199789539339 0.0781224750022211 no 3093 0.0568250254710436 4590 3887424
SGTC_1772 st048439 82.2 µM -1.58718179579937 0.0774303665129049 no 3094 0.0562357382567196 4570 2927068 YDL195W SEC31
SGTC_1305 1181-0477 144 µM -1.59138864377665 0.0768721364406397 no 3095 0.0557610692257359 4570 6252086
SGTC_1624 st003710 6.25 µM -1.59524986786949 0.0763624668082382 no 3096 0.055328185642128 4573 24207033
SGTC_1368 1852-0141 284 µM -1.59604384902761 0.0762579831923431 no 3097 0.0552395018815853 4523 2838987
SGTC_2139 5578692 56.4705 µM -1.59904927367403 0.0758634707887365 no 3098 0.0549048272893142 4533 650991 YMR113W FOL3
SGTC_982 1491-0518 27.5 µM -1.60139046669939 0.0755572284139617 no 3099 0.0546452314583905 4500 3091256
SGTC_2065 5221596 34.26 µM -1.60222662412716 0.0754480824896383 no 3100 0.0545527523179421 4513 788581
SGTC_2836 9010338 19.48 µM -1.60515831685584 0.075066349674426 no 3101 0.0542294840536788 4507 2994051
SGTC_2777 climbazole 1.536 µM -1.60706766427908 0.0748185285840036 no 3102 0.0540197628521399 4356 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_958 1222-0007 33 µM -1.61105054917743 0.0743035853081445 no 3103 0.0535843526425914 4592 7312461
SGTC_2966 9084041 48.03 µM -1.61121936881517 0.0742818187214508 no 3104 0.0535659588278392 4500 17741380
SGTC_1888 azatryptophan 97.5 µM -1.61285579128246 0.0740710805656915 no 3105 0.0533879208687093 4557 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_33 0986-0033 35.816 µM -1.61332699885631 0.0740104833221156 no 3106 0.0533367419213585 4543 2848082
SGTC_2085 5307070 144.047 µM -1.61472002824914 0.0738315613846289 no 3107 0.0531856691395594 4494 2840351
SGTC_1021 4476-0760 85.3 µM -1.62068884472903 0.0730686622574417 no 3108 0.0525421936176417 4569 746768
SGTC_275 trichlorophene 5.69 µM -1.62090622913692 0.0730409917441202 no 3109 0.0525188753658313 4582 62616
SGTC_2749 bexarotene 57.39 µM -1.62236839889121 0.0728550828308161 no 3110 0.0523622456428535 4557 82146 An retinoic acid receptor inhibitor.
SGTC_1963 st076565 50.3 µM -1.62827114622462 0.0721082540492501 no 3111 0.0517337023931604 4572 4914280
SGTC_2164 5685496 200 µM -1.62935153744399 0.0719721981580481 no 3112 0.0516193108848389 4492 759046
SGTC_2563 tomatine 8.54 µM -1.63088922311907 0.0717788937838273 no 3113 0.051456848067431 4487 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1042 0350-0096 82 µM -1.631138224751 0.0717476289776809 no 3114 0.0514305783187309 4552 3122515
SGTC_1826 st055655 41.6 µM -1.63423462162619 0.0713597154600957 no 3115 0.0511047977443155 4555 676168
SGTC_2271 7849410 118.62 µM -1.63593087661794 0.0711478939124006 no 3116 0.0509270274877554 4498 972430
SGTC_2446 5162541 200 µM -1.63595991168191 0.0711442723369644 no 3117 0.050923988857006 4526 1549321
SGTC_1262 0737-0114 49.6 µM -1.64383021802918 0.0701678099828679 no 3118 0.0501056388051456 4584 765919
SGTC_603 3794-0023 45.9 µM -1.65037110967309 0.0693641581607791 no 3119 0.0494335281488642 4602 3802260
SGTC_924 2046-0044 21.3 µM -1.65106578924218 0.0692792239798994 no 3120 0.0493625709764665 4535 3623589
SGTC_2726 cimetidine 79.27 µM -1.65854840165527 0.0683694432559901 no 3121 0.0486034132805982 4577 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_70 0141-0289 43.283 µM -1.65948598116357 0.0682560996757856 no 3122 0.0485089516172446 4526 352408
SGTC_847 0342-0274 5.54 µM -1.66431524834838 0.0676745874167351 no 3123 0.0480247233772401 4573 18097
SGTC_1167 k781-0610 148 µM -1.66908391978092 0.0671041347267614 no 3124 0.0475503748130141 4603 4525169
SGTC_2822 7994718 71.43 µM -1.6713868927463 0.0668299763421043 no 3125 0.0473226415905411 4579 1018011
SGTC_828 2074-0507 139 µM -1.67314901769367 0.0666207892836988 no 3126 0.0471489819389408 4606 X828
SGTC_2925 9010536 32.5 µM -1.67599305362264 0.0662842348860405 no 3127 0.0468697766197606 4496 2994177
SGTC_1199 1638-0010 4.46 µM -1.67677571254255 0.066191848871938 no 3128 0.0467931743883193 4562 3111136
SGTC_1190 1486-1332 13 µM -1.67755263363098 0.0661002388330447 no 3129 0.0467172331040297 4569 4150046
SGTC_874 0599-0792 117 µM -1.68736134809798 0.0649520829352421 no 3130 0.0457669456298013 4573 765305
SGTC_1560 lithocholic acid 53.1 µM -1.693055674 0.0642926733668443 no 3131 0.0452224352134742 4542 9903 A bile acid which acts as a detergent.
SGTC_1597 7-benzyloxygramine 47.5 µM -1.69651985427159 0.0638940698422922 no 3132 0.0448937367092641 4492 260807
SGTC_2649 anisomycin 9.56 µM -1.7015132241959 0.0633228962460423 no 3133 0.0444233283707321 4635 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3102 9121669 49.47 µM -1.70392630761181 0.063048300757797 no 3134 0.0441974277296422 4619 41905072
SGTC_1697 st025554 27.742 µM -1.70541444929553 0.0628794214035886 no 3135 0.044058577686914 4616 1269519
SGTC_2751 anetholtrithion 17.25 µM -1.71002249793793 0.0623587191972861 no 3136 0.0436308564242004 4548 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1287 0971-0001 34.6 µM -1.71383252784657 0.0619307365327331 no 3137 0.0432797437967241 4591 4665869
SGTC_587 k089-0003 57 µM -1.72074968446182 0.0611595914202195 no 3138 0.0426481281524677 4530 9659696
SGTC_1276 0871-0068 94.2 µM -1.72692402748945 0.0604776144773186 no 3139 0.0420906542953842 4611 3414906
SGTC_3338 9144300 39.5675 µM -1.73042898289292 0.0600931363208288 no 3140 0.0417768296642111 4589 4901274
SGTC_1689 st020265 53.493 µM -1.73111972919142 0.0600175907361423 no 3141 0.0417152061097038 4592 5758320 YPR016C TIF6
SGTC_1989 st071868 50.2 µM -1.73722193067915 0.0593534313608346 no 3142 0.0411740026806791 4605 16414057
SGTC_2683 piperine 63.03 µM -1.74634482133103 0.0583712657035484 no 3143 0.0403755259344497 4648 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1116 jasmonic acid 1.58368 µM -1.74890896210743 0.0580975222208124 no 3144 0.0401533785901583 4646 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_941 3237-0776 460 µM -1.75255186198557 0.0577103480197054 no 3145 0.0398394801689907 4602 760008
SGTC_2833 9001315 45.46 µM -1.75399245181308 0.0575578003998607 no 3146 0.0397159002666728 4544 2989378
SGTC_1818 st052136 56.3 µM -1.76290304392281 0.0566212725452375 no 3147 0.0389584217926049 4280 674169
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.76429189265344 0.0564763883080533 no 3148 0.0388414241187629 4590 521171
SGTC_1660 st012960 28.1 µM -1.76734365198867 0.0561590561663409 no 3149 0.0385853467499535 4630 24207266
SGTC_2340 7987427 183.45 µM -1.77268751515595 0.055606771674579 no 3150 0.0381402505085286 4603 2239331
SGTC_2319 6033012 152.6 µM -1.77399529063662 0.0554722690788443 no 3151 0.0380319646443915 4563 847246
SGTC_875 0709-0210 25.7 µM -1.77685077153961 0.0551794802208769 no 3152 0.0377963979024484 4602 6251364
SGTC_1713 st033146 12.748 µM -1.78029315015919 0.0548281377415752 no 3153 0.037513998780725 4584 674619
SGTC_1558 st069300 45.6 µM -1.78377783318337 0.0544742808722024 no 3154 0.0372298864514633 4598 24208000
SGTC_1655 st012546 55.1 µM -1.786388022928 0.0542104107512285 no 3155 0.0370182267603629 4614 720985 YLR208W SEC13
SGTC_709 3807-1509 243 µM -1.79294883566995 0.0535516283854528 no 3156 0.0364905527744041 4681 1886677 YPL242C IQG1
SGTC_2944 9067346 25.62 µM -1.79932705300903 0.0529172767383197 no 3157 0.0359834805712388 4550 6473075
SGTC_2778 tioconazole 65.09 nM -1.79999011118516 0.0528516751006914 no 3158 0.0359310998433716 4521 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1632 st005650 90 µM -1.80353959899484 0.0525015923065362 no 3159 0.0356517561379785 4631 2759605
SGTC_3228 9131799 49.47 µM -1.80403264135716 0.0524531099151932 no 3160 0.0356130950195222 4663 17015818
SGTC_1508 1080-0625 72.9 µM -1.80532422534423 0.0523262729297092 no 3161 0.0355119804585782 4587 767111
SGTC_2144 5628481 200 µM -1.81169468069412 0.0517042362878999 no 3162 0.0350166930016382 4624 2818399
SGTC_3290 9121031 71.43 µM -1.81235771861304 0.0516398337873586 no 3163 0.0349654707409825 4635 17014854
SGTC_1324 1418-0026 34.4 µM -1.81301344777327 0.0515762039463277 no 3164 0.0349148736120514 4646 1372513
SGTC_1562 morin hydrate 59.1 µM -1.81962921309128 0.0509377131768936 no 3165 0.0344077449027038 4630 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1953 st076800 12.1 µM -1.83000824183308 0.0499487240354414 no 3166 0.0336243532132207 4599 297591
SGTC_201 4262-0159 12.803 µM -1.8302339197741 0.0499273911323742 no 3167 0.0336074838553952 4676 1341029
SGTC_1347 1493-0251 600 nM -1.83961048244129 0.049047447414618 no 3168 0.0329127221498829 4669 3986378
SGTC_288 1315-0019 35.1 µM -1.84259501220936 0.0487699779690346 no 3169 0.0326940813560526 4669 6811474
SGTC_1523 st012844 44.7 µM -1.84290245265378 0.0487414668820572 no 3170 0.0326716270719955 4655 4274103
SGTC_3000 9075062 71.4286 µM -1.84442940777351 0.0486000590748388 no 3171 0.0325602924162262 4629 17057871
SGTC_3156 9099931 49.47 µM -1.84618303302667 0.0484380647100092 no 3172 0.0324328168448932 4668 18111053
SGTC_216 k038-0035 28.382 µM -1.84976900068114 0.0481081488035336 no 3173 0.0321734252898818 4597 4444231 YPR107C YTH1
SGTC_155 k072-0202 43.6 µM -1.86155972467727 0.0470360392053587 no 3174 0.031332587379926 4632 5857737
SGTC_2229 7354935 190 µM -1.86186782611099 0.0470082830462838 no 3175 0.0313108615592773 4640 318112
SGTC_178 4092-0806 87.505 µM -1.86457819687366 0.0467646774718478 no 3176 0.0311202756718969 4529 2169044
SGTC_2688 kanamycin b 96.69 µM -1.87330597422576 0.0459871076846299 no 3177 0.0305130726898824 4587 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3262 9137218 49.47 µM -1.8761225932981 0.0457383997894223 no 3178 0.0303192239799202 4664 17650664
SGTC_2153 5569715 200 µM -1.87784075522633 0.0455872174841579 no 3179 0.0302014765358322 4675 2054701
SGTC_380 3970-0968 6 µM -1.878905464833 0.0454937347185154 no 3180 0.0301287012667451 4575 2891601
SGTC_1940 st075990 51.1 µM -1.88322693085222 0.0451158863838146 no 3181 0.0298348104279908 4670 1084979
SGTC_1332 1480-0653 17.5 µM -1.88388695758439 0.04505839974482 no 3182 0.0297901338907676 4663 5749438
SGTC_215 1287-0124 461.5 µM -1.90198850889622 0.0435046498498746 no 3183 0.0285863284433439 4704 5560863
SGTC_1680 diphenhydramine 100 µM -1.90202231020142 0.0435017894871206 no 3184 0.0285841189823423 4604 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1645 Cervolide 78 µM -1.90401403984492 0.0433335114804045 no 3185 0.0284541778498826 4685 23173 A fragrance.
SGTC_1313 1220-0047 237 µM -1.90441229793346 0.0432999264381231 no 3186 0.0284282544029367 4665 3528706
SGTC_2882 9058044 58.44 µM -1.90742665635624 0.0430464071454352 no 3187 0.0282326801283947 4669 18076804
SGTC_2712 st079126 47.7 µM -1.91205765183913 0.0426592600188914 no 3188 0.0279343998978092 4661 3152970
SGTC_2291 7917025 104.35 µM -1.9132249468689 0.0425621206965317 no 3189 0.0278596305764585 4569 2964612
SGTC_2111 5486399 200 µM -1.91687965909655 0.0422591410264389 no 3190 0.0276266108937974 4621 689674
SGTC_355 1311-2252 105 µM -1.91871097519734 0.042107980496075 no 3191 0.0275104608809439 4624 5338538
SGTC_1479 0549-0158 134 µM -1.95349450348107 0.039319064305216 no 3192 0.0253805139769731 4717 5440202
SGTC_2383 9036125 200 µM -1.95367814627461 0.0393047489409751 no 3193 0.025369646177528 4641 79580
SGTC_3340 9146634 11.102 µM -1.95465297945094 0.0392288295214192 no 3194 0.0253120217590355 4669 4907387
SGTC_172 1112-0046 2.638 µM -1.96639079630939 0.0383240320483177 no 3195 0.024626742883355 4667 2802135 YIL048W NEO1
SGTC_2872 9044037 25.97 µM -1.97009741924679 0.0380418712795682 no 3196 0.0244136033239271 4718 6465195
SGTC_1434 4073-0095 163 µM -1.98113618439914 0.0372115877626404 no 3197 0.023788001694464 4691 24133745
SGTC_2762 leflunomide 42.06 µM -1.98888298786309 0.0366377981646039 no 3198 0.0233570599697476 4650 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2792 7535235 81.82 µM -1.99027687112875 0.0365353284320564 no 3199 0.0232802221928716 4638 1281891
SGTC_749 1000-0129 128 µM -1.99293384049672 0.0363406538735794 no 3200 0.0231343460668572 4696 708470
SGTC_1224 0823-0416 294 µM -2.00384763987265 0.0355498935819138 no 3201 0.0225431919161636 4700 3598164
SGTC_2809 7964133 12.99 µM -2.00659529158972 0.0353530506979616 no 3202 0.0223963865369646 4656 1253665
SGTC_2249 haloperidol 116.36 µM -2.01353570443864 0.0348598149243154 no 3203 0.0220291513585854 4615 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2134 5324836 1.464 µM -2.01460733060025 0.0347841633322904 no 3204 0.0219729043912736 4674 699272
SGTC_51 1013-0126 23.419 µM -2.01496898874331 0.0347586624709702 no 3205 0.0219539492494941 4675 1627850
SGTC_156 3474-0145 5.642 µM -2.02438394566492 0.0341001881670522 no 3206 0.0214653311564617 4629 2265471
SGTC_1470 k295-0292 231 µM -2.02670243653105 0.0339396183873634 no 3207 0.0213464265771995 4733 5045612
SGTC_209 4077-0173 175.592 µM -2.03100516944107 0.0336432756574591 no 3208 0.0211272351041542 4675 15993494
SGTC_1389 3405-0187 19 µM -2.03860147353861 0.0331252940431089 no 3209 0.0207449090292105 4674 799890
SGTC_44 0929-0055 61.211 µM -2.04010526894149 0.0330235353696932 no 3210 0.0206699210264167 4537 1379590
SGTC_1100 amiodarone 5.07 µM -2.0529220686534 0.0321666617914434 no 3211 0.0200400681534538 4705 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2091 4-phenylthiadiazole 200 µM -2.0603955272633 0.031675547924453 no 3212 0.019680372074926 4711 270010
SGTC_2222 6885208 172.143 µM -2.06505259445957 0.0313726569646132 no 3213 0.019459012081795 4728 609514
SGTC_1520 flindersine 88 µM -2.07087339098318 0.030997449496788 no 3214 0.0191853147099305 4686 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3042 9091578 49.47 µM -2.07243993233066 0.0308971071020585 no 3215 0.0191122162976749 4696 25236497
SGTC_2524 avocatin b 10.57 µM -2.07376701441505 0.0308123133846304 no 3216 0.0190504770031373 4723 6710748
SGTC_157 1348-1695 65.819 µM -2.07539067407091 0.0307088320080648 no 3217 0.0189751709087369 4635 5380510
SGTC_1777 st045864 34.765 µM -2.07805622278008 0.0305395715694207 no 3218 0.0188520905436209 4715 4691462
SGTC_1080 nisoldipine 24.4 µM -2.08052515144771 0.0303834864204522 no 3219 0.0187386955743217 4732 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1356 1502-0781 85.8 µM -2.08225931384179 0.0302742486948623 no 3220 0.0186593950391664 4716 567702
SGTC_382 3229-0966 23.2 µM -2.09439395539591 0.029518941937701 no 3221 0.0181124503933365 4716 5722370
SGTC_1644 st010134 20.9 µM -2.09484876634815 0.0294909396630916 no 3222 0.0180922192328068 4696 3818134
SGTC_2247 cerulenin 830 nM -2.09784837366381 0.0293068085378882 no 3223 0.0179592708783725 4714 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_224 benfluorex 43.875 µM -2.10195272911569 0.0290564102537083 no 3224 0.0177787084301777 4719 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_31 0508-1974 57.237 µM -2.1030695845855 0.0289885817113297 no 3225 0.0177298436223272 4677 6810525
SGTC_774 k060-0086 136 µM -2.1055262265084 0.0288398486090647 no 3226 0.0176227634192069 4702 5911235
SGTC_1766 st045414 44.774 µM -2.11112006470583 0.0285035452020635 no 3227 0.0173809966097604 4709 253960
SGTC_2253 7938677 135.83 µM -2.12115799632648 0.027908242098981 no 3228 0.0169542543479906 4717 2301972
SGTC_1359 1582-0056 520 nM -2.12990075306968 0.0273982223829211 no 3229 0.0165899039833393 4740 3661189
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.13419805693764 0.027150397003995 no 3230 0.0164132858505857 4703 4000243
SGTC_2620 irigenin 100 µM -2.14294114761538 0.0266519546547941 no 3231 0.0160589121856133 4684 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1877 wortmannin 25 µM -2.14461003455258 0.0265576856928285 no 3232 0.0159920196644136 4712 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2437 5741531 144.16 µM -2.145363603813 0.0265152108633534 no 3233 0.0159618933730759 4713 2262990
SGTC_2165 5727197 32.143 µM -2.14713253746287 0.0264157281184363 no 3234 0.0158913658005544 4699 1361712
SGTC_1881 5652484 16 µM -2.1475343406665 0.0263931747061959 no 3235 0.0158753831552136 4693 2255129
SGTC_91 0417-1751 58.384 µM -2.14759954061495 0.0263895165189214 no 3236 0.0158727909776944 4743 6795624
SGTC_3318 9139014 38.6185 µM -2.15391163106491 0.0260373637085768 no 3237 0.0156235513277588 4697 16643984
SGTC_528 3492-0019 172 µM -2.15950259497768 0.0257287335888054 no 3238 0.0154055981141358 4713 2869262
SGTC_2513 baicalein 25.65 µM -2.1601062556251 0.0256955944670326 no 3239 0.0153822224346725 4687 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3298 9116858 71.43 µM -2.1642680661188 0.0254680947857638 no 3240 0.0152218910330706 4748 2506942
SGTC_1420 4'-methoxyflavone 42 µM -2.18479896172333 0.0243703462272947 no 3241 0.0144517951101966 4731 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_764 1951-2361 146 µM -2.18626211272309 0.0242936543346692 no 3242 0.0143982171631776 4727 5438930
SGTC_2080 5212524 12.4 µM -2.18801526687297 0.0242020287596821 no 3243 0.014334245134041 4688 260183
SGTC_363 0455-0021 3.06 µM -2.19423299576819 0.0238794067433516 no 3244 0.014109331810369 4656 4597466
SGTC_1797 st048695 56.8 µM -2.20872326519799 0.0231415498342041 no 3245 0.0135969475931918 4708 592262 YIL048W NEO1
SGTC_585 0kpi-0023 191 µM -2.20896090545628 0.0231296108116471 no 3246 0.0135886801292257 4688 64601
SGTC_1005 4092-0690 4.4 µM -2.21060892819682 0.0230469569308205 no 3247 0.0135314649790709 4702 1529343
SGTC_2586 curcumin 80 µM -2.21435947689571 0.022859781122933 no 3248 0.0134020300852315 4645 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1285 0929-0069 65.5 µM -2.2286362380533 0.0221589569191584 no 3249 0.0129190589353924 4740 1206237
SGTC_1821 st053465 65.6 µM -2.23113488789817 0.0220381856284909 no 3250 0.0128360976970253 4740 675086
SGTC_1961 st076550 68.7 µM -2.24862224076206 0.0212083992650778 no 3251 0.0122682700897617 4731 1579337
SGTC_2178 5812956 200 µM -2.25365544585038 0.0209745255533448 no 3252 0.0121089261563804 4714 5403383
SGTC_1920 st075728 45.7 µM -2.25468720647006 0.020926854139802 no 3253 0.0120764846252996 4713 3400306
SGTC_1189 1431-2119 7.28 µM -2.25618158302997 0.0208579706706816 no 3254 0.0120296307334983 4732 3107275
SGTC_56 0957-0365 83.25 µM -2.25718620058024 0.0208117706762242 no 3255 0.0119982211596455 4679 6752360
SGTC_1633 st005664 67.9 µM -2.25912325407388 0.0207229347043524 no 3256 0.0119378595077343 4711 2063822
SGTC_2516 gossypol 71.55 µM -2.26321461985395 0.0205363540044256 no 3257 0.011811231213296 4739 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_421 streptovitacin 30 mM -2.26413565612791 0.0204945483317712 no 3258 0.0117828862750739 4719 91467 include heat shock
SGTC_77 0828-0286 12.516 µM -2.29513104776428 0.0191291332606271 no 3259 0.0108628076282859 4663 745345
SGTC_586 0957-0265 8.15 µM -2.30313672632686 0.0187893023579573 no 3260 0.0106355757500279 4687 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2875 9039966 71.43 µM -2.30484010508945 0.0187176626942433 no 3261 0.0105877650366911 4745 6463691
SGTC_423 5-fluorouracil 457 µM -2.30593479319827 0.0186717457804736 no 3262 0.0105571380724147 4690 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_768 0384-0033 77.3 µM -2.32934154313233 0.0177126456624396 no 3263 0.00992048961371507 4723 3965305 YMR134W ERG29
SGTC_2709 st078560 56 µM -2.3316367406435 0.0176209034431932 no 3264 0.00985990464632099 4727 17250903
SGTC_338 4055-0136 114 µM -2.33267584880052 0.0175795024033674 no 3265 0.00983258234524613 4730 2900563
SGTC_649 1123-0311 367 µM -2.3366405873308 0.0174222978174303 no 3266 0.00972894009457948 4663 693629 YIL048W NEO1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.33930217718472 0.0173174387234308 no 3267 0.00965990005599813 4742 6708784 An antioxidant flavonoid
SGTC_2865 9030313 51.95 µM -2.3493026603447 0.0169282524767078 no 3268 0.00940430561530698 4735 42562754
SGTC_139 0099-0334 718.624 µM -2.36549865259132 0.0163138228783757 no 3269 0.00900290440712352 4730 97690
SGTC_1784 st039334 36.3 µM -2.38077372351299 0.0157519323495697 no 3270 0.00863816022411669 4743 3496984
SGTC_2168 5727979 200 µM -2.39693722229943 0.0151755185975659 no 3271 0.00826637799273279 4718 695210
SGTC_2001 4023502 57.655 µM -2.4029431229145 0.0149660056911401 no 3272 0.0081318583938346 4733 108941 YCR052W RSC6
SGTC_1250 0485-0349 40.2 µM -2.41326197531144 0.0146118418067102 no 3273 0.00790522546723575 4727 6842794 YDL195W SEC31
SGTC_1384 3089-0840 101 µM -2.42071670206543 0.0143604892307258 no 3274 0.00774497187366219 4757 1069836
SGTC_2303 7774051 200 µM -2.42246518159377 0.0143020773488492 no 3275 0.00770780147944918 4736 2953184
SGTC_1901 st060216 58.6 µM -2.42480923795472 0.0142240900152188 no 3276 0.00765821629365866 4750 688792
SGTC_451 chloral hydrate 100 µM -2.43629868604965 0.0138471099347267 no 3277 0.00741921319551234 4740 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_724 3910-0327 137 µM -2.44543837280005 0.0135534112677761 no 3278 0.00723380858415314 4751 2885483
SGTC_486 niguldipine 82 µM -2.45604990362666 0.0132191752845834 no 3279 0.00702368243894003 4787 1236 A calcium channel blocker.
SGTC_2812 7970281 58.44 µM -2.45786821055266 0.0131626237747267 no 3280 0.00698822265019019 4755 2233435
SGTC_988 1497-1057 103 µM -2.45817489749479 0.0131531060784097 no 3281 0.0069822573820825 4753 3533044
SGTC_1800 st050079 29.0735 µM -2.48368198412407 0.012382057094105 no 3282 0.00650159371846508 4657 3645560
SGTC_463 ikarugamyin 104 µM -2.48478697189893 0.0123495583792257 no 3283 0.00648144902686659 4804 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_651 3253-0966 34.4 µM -2.48661207135064 0.0122960423147962 no 3284 0.00644829709842071 4767 781462
SGTC_940 3232-1287 54.8 µM -2.49152566577377 0.0121529620644702 no 3285 0.00635978884631779 4749 1585493 YIL048W NEO1
SGTC_805 3852-0218 479 µM -2.49710329046959 0.0119922966462811 no 3286 0.00626062394241701 4764 6615355
SGTC_2021 4019055 173 µM -2.5116138740487 0.0115829162134178 no 3287 0.00600902525032611 4617 44827708 YER133W GLC7
SGTC_2702 st077768 96.8 µM -2.51716109274721 0.0114296519547252 no 3288 0.00591523620815713 4752 6484119
SGTC_2219 9098279 200 µM -2.52839693846987 0.0111246069127404 no 3289 0.00572923611753872 4762 902349
SGTC_2943 9068529 45.32 µM -2.53777939947244 0.0108753288912635 no 3290 0.00557791398798281 4731 3270634
SGTC_2871 9038510 12.99 µM -2.55069673019973 0.0105400955366486 no 3291 0.00537539148458015 4741 4945164
SGTC_441 propafenone 146 µM -2.55600377592379 0.0104049971311576 no 3292 0.00529409849487223 4758 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_308 4092-1169 104 µM -2.56303303913491 0.0102283823728855 no 3293 0.00518810869848831 4744 2268590 YDL196W YDL196W
SGTC_1118 chelidonine 707.474 nM -2.57274686598205 0.00998862216499924 no 3294 0.00504474859750462 4753 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_374 0880-0231 82.3 µM -2.57721325817354 0.00988003740092282 no 3295 0.00498002400482606 4683 6833587
SGTC_2217 6934799 96.0675 µM -2.57866834853179 0.00984488524896001 no 3296 0.00495909793270067 4773 675606
SGTC_1025 k007-0731 70 µM -2.58436524846486 0.00970830804421655 no 3297 0.00487792092339909 4753 6256118
SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.58959312761379 0.00958443472926958 no 3298 0.0048044714121851 4781 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2877 9040724 71.43 µM -2.60093791823588 0.00932036545182803 no 3299 0.00464846383187634 4741 6463895
SGTC_2275 7947463 200 µM -2.60383873422951 0.00925387459105845 no 3300 0.00460930608248278 4761 1225414
SGTC_2273 7815444 169.05 µM -2.60687247580276 0.00918478132392583 no 3301 0.00456866917311239 4730 2824616
SGTC_1803 st050068 52.4 µM -2.60998731068529 0.00911431141522713 no 3302 0.00452727906235567 4765 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1477 0139-0234 16 µM -2.62119389399241 0.00886467458825176 no 3303 0.00438112056762189 4774 620880
SGTC_1393 3470-5649 58.2 µM -2.62784394288399 0.00871938888623268 no 3304 0.0042963963040509 4769 4108395
SGTC_1690 st023502 41.2 µM -2.63305870409843 0.00860692509573573 no 3305 0.00423098600857313 4787 24207482
SGTC_1929 genistein trimethyl ether 50.5 µM -2.65717724477573 0.0081031655081146 no 3306 0.00393990011229166 4764 136420
SGTC_2171 5739187 198.077 µM -2.66763623806371 0.0078928902786159 no 3307 0.00381934561893806 4759 2262761
SGTC_2337 9009472 200 µM -2.70578383094388 0.00716606425746673 no 3308 0.00340716939102556 4735 5742383
SGTC_2265 7929201 200 µM -2.70682281830713 0.00714712278443507 no 3309 0.00339652508889884 4751 1265108
SGTC_899 1083-0020 478 µM -2.7232258602493 0.0068538824961063 no 3310 0.00323239220090504 4780 767123
SGTC_1367 1812-0510 76.9 µM -2.7660051795492 0.00613852360476994 no 3311 0.00283738167327786 4779 1142582 YDR527W RBA50
SGTC_898 1000-0849 28.3 µM -2.78782885288914 0.00579972155511498 no 3312 0.00265312842179498 4780 6751807
SGTC_1553 gossypol 38.6 µM -2.79286699823525 0.00572390477006793 no 3313 0.00261215837730594 4786 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_129 0088-0017 176.636 µM -2.80995261822893 0.00547329967091702 no 3314 0.00247743969725332 4733 182446
SGTC_1962 st076595 64.5 µM -2.8340502271397 0.00513642453728195 no 3315 0.00229810536689369 4767 279619
SGTC_314 1671-0008 2.74 µM -2.84295434347376 0.00501669736540896 no 3316 0.00223487364361133 4707 3913060
SGTC_312 4092-0653 6.84 µM -2.84952654005433 0.00492992673268971 no 3317 0.00218921763091968 4727 1148278
SGTC_96 0929-0093 37.281 µM -2.89609308763277 0.00435248829024933 no 3318 0.00188920150811897 4792 6991579
SGTC_171 k064-0041 9.68 µM -2.91501526646101 0.00413566792216662 no 3319 0.0017783557189049 4764 53325
SGTC_2969 9091408 28.7 µM -2.9723794828256 0.0035361866442006 no 3320 0.00147750598242433 4755 4286311
SGTC_1993 st073995 70.8 µM -2.98266698049072 0.0034373330021399 no 3321 0.00142874363372986 4789 3098394
SGTC_2457 5731572 11.68 µM -2.98750087210383 0.0033917468045665 no 3322 0.00140634246160704 4795 2865357
SGTC_3018 9082602 49.47 µM -2.9893829715399 0.0033741450583338 no 3323 0.0013977075521034 4720 17332089
SGTC_1939 st074455 53.6 µM -2.99666146072251 0.0033068453708586 no 3324 0.00136476824696226 4766 1644229
SGTC_187 1488-2104 32.728 µM -3.00642147942095 0.00321849539491577 no 3325 0.00132171157275296 4798 2852859
SGTC_1268 0828-0275 2.46 µM -3.03000239341215 0.00301373627381989 no 3326 0.00122275900370158 4798 745337
SGTC_102 gallobenzophenone 83.616 µM -3.09383163290857 0.0025170538340057 no 3327 0.000987947919170314 4792 70837
SGTC_130 0136-0219 337.655 µM -3.10169978878684 0.00246125274314061 no 3328 0.000962064917898179 4768 234244
SGTC_1914 st062367 72.6 µM -3.1333821331939 0.00224770878721748 no 3329 0.00086402153049817 4789 978205
SGTC_715 0868-0130 184 µM -3.17872183513103 0.00197125450983995 no 3330 0.000739629879182726 4803 2876258
SGTC_2572 astragaloside iv 100 µM -3.18641788188308 0.00192751976008883 no 3331 0.000720231866722263 4785 45006101 An anti-inflammatory agent.
SGTC_2301 7769476 200 µM -3.20992362400761 0.001799344838244 no 3332 0.000663851226798106 4785 977820
SGTC_327 1273-0057 3.96 µM -3.22212401202603 0.00173591900913852 no 3333 0.000636220240185402 4788 3108138
SGTC_2106 5357045 167.29 µM -3.2592154035737 0.00155538736401442 no 3334 0.000558604040378281 4799 668842
SGTC_2343 7990716 14.84 µM -3.27905560454674 0.00146601065064287 no 3335 0.000520775555714125 4790 6456862
SGTC_1193 1488-0126 41.5 µM -3.28177031547068 0.00145415277788876 no 3336 0.000515787976707379 4790 1384710
SGTC_359 0081-0058 15.9 µM -3.35933163319316 0.00115021962509382 no 3337 0.000390656221659368 4782 3494159
SGTC_1780 st038448 24.544 µM -3.44318997535043 0.00088793431896475 yes 3338 0.000287447658578974 4794 728868 YDL195W SEC31
SGTC_2521 angolensin 13.4 µM -3.45619302836168 0.000852584531044319 yes 3339 0.000273931417778137 4805 821428 A flavenoid.
SGTC_3 0833-0587 95.581 µM -3.45999266935649 0.000842502026082138 yes 3340 0.000270095046848309 4724 5382644
SGTC_999 SEC7.066 22.7 µM -3.55677917099933 0.000619875366214989 yes 3341 0.000187714743281076 4804 740511 YDR170C SEC7
SGTC_2544 sphondin 68.51 µM -3.61390239045308 0.000515402878217221 yes 3342 0.000150811326335186 4795 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_162 k030-0015 37.8 µM -3.70455699630878 0.0003825077775212 yes 3343 0.000105880245630982 4805 1809920 YMR134W ERG29
SGTC_2896 9052656 71.43 µM -3.70616570013373 0.000380466695577001 yes 3344 0.00010521033064748 4593 6469436
SGTC_1718 roemerine 11.9335 µM -3.72133392999436 0.000361712757864775 yes 3345 9.908658694218e-05 4654 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2243 6634756 200 µM -3.74124865654623 0.00033839301519881 yes 3346 9.15541215064061e-05 4801 885676
SGTC_133 0724-0033 378.92 µM -3.80561163950566 0.00027223790216128 yes 3347 7.07270957345889e-05 4797 280309
SGTC_949 1165-0505 146 µM -3.85203404914909 0.000232232916648598 yes 3348 5.85703648675825e-05 4786 6244267
SGTC_2259 7964009 200 µM -3.86085661737111 0.000225279480992745 yes 3349 5.6495098654329e-05 4805 313134
SGTC_445 e6 berbamine 66 µM -3.91753865683724 0.000185038440186833 yes 3350 4.47288518048865e-05 4807 6610268 A calcium/calmodulin antagonist.
SGTC_2811 7967822 32.47 µM -3.95330507474065 0.000163217274436811 yes 3351 3.85395297462129e-05 4802 2232244
SGTC_393 acivicin 6.25 µM -4.05310487816491 0.000114384400847041 yes 3352 2.52711650378215e-05 4796 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_666 0272-0154 136 µM -4.28014369634094 4.94606493970615e-05 yes 3353 9.33863407464781e-06 4808 6870312
SGTC_2250 alverine citrate 130 µM -4.90180151943859 4.03042659706943e-06 yes 3354 4.74808779989109e-07 4795 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1712 st032288 53.4 µM -5.32657136433089 6.07224709659892e-07 yes 3355 5.00419842181068e-08 4803 2883011
SGTC_660 4031-1742 102 µM -7.33082372538919 1.10023356237691e-11 yes 3356 1.14371186538366e-13 4810 6738706