SGTCid condition conc unit RPS26B|YER131W.score RPS26B|YER131W.strain.pval RPS26B|YER131W.strain.significant RPS26B|YER131W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_428 3448-4153 16.5 µM 7.02374979088851 2.59324704374814e-12 yes 1 1.0799573125698e-12 4 3834874 SGTC_814 3342-0569 96 µM 5.94016609263115 2.66202153934156e-09 yes 2 1.42366723909089e-09 4 4346283 SGTC_1613 st002381 52.1 µM 5.82538863433318 5.20081390476367e-09 yes 3 2.8489922800066e-09 4 551167 SGTC_422 cantharidin 155 µM 5.39006354908828 5.89491464959353e-08 yes 4 3.52163863458577e-08 25 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3334 9142812 21.919 µM 5.2344947232371 1.34463421955014e-07 yes 5 8.2718398788124e-08 9 45283678 SGTC_1836 st055642 81 µM 4.96136448436565 5.41548262058304e-07 yes 6 3.49998494868254e-07 7 8571 SGTC_536 3852-0578 10.6 µM 4.51339502210875 4.57860926761143e-06 yes 7 3.18990175092354e-06 17 2869208 SGTC_2950 9072895 21.46 µM 4.39306702716354 7.87042634454655e-06 yes 8 5.58813254440322e-06 27 17332245 SGTC_2215 7188065 200 µM 4.36763278527062 8.81014860526623e-06 yes 9 6.28002180211709e-06 3 940217 SGTC_1604 st002052 72.4 µM 4.31831339478288 1.0945375278269e-05 yes 10 7.86130364397745e-06 20 6254834 YHR062C RPP1 SGTC_1953 st076800 12.1 µM 4.26466678115119 1.38242217461189e-05 yes 11 1.00100377280104e-05 40 297591 SGTC_901 1112-0062 60.1 µM 4.08081005820535 3.01618392884095e-05 yes 12 2.24395094211614e-05 8 1908457 SGTC_625 k213-0058 121 µM 3.8960572893379 6.40235054477996e-05 yes 13 4.88856357747583e-05 111 3655420 SGTC_118 0083-0097 135.343 µM 3.80905878754658 9.02738687539587e-05 yes 14 6.97483956693869e-05 150 5207356 SGTC_6 0844-0013 19.835 µM 3.77148251885121 0.000104492423346016 yes 15 8.11402641944449e-05 103 1584900 SGTC_800 3448-7362 155 µM 3.69695372482174 0.000139129617276214 yes 16 0.000109101048993739 187 15991913 SGTC_527 4476-4215 268 µM 3.66705429568289 0.000155841046733928 yes 17 0.000122680355367004 46 4418754 SGTC_1109 tnp00067 928.257 nM 3.59668901925609 0.000202871175588633 yes 18 0.00016114670450542 22 676295 SGTC_740 k014-0057 261 µM 3.53240976525084 0.000257124095524722 yes 19 0.000205895366718982 39 4012779 SGTC_2755 lomerizine 42.69 µM 3.45207848553282 0.000343935442879748 yes 20 0.00027814294470334 38 3949 A calcium channel blocker. SGTC_530 4358-1714 28 µM 3.33646524169468 0.000517417604542508 yes 21 0.000424255190342115 67 1564641 SGTC_1374 2889-5571 141 µM 3.27508649401376 0.000639545106459294 yes 22 0.000528148136579351 77 2853281 SGTC_3006 9075424 71.4286 µM 3.25720190407753 0.000679843927872994 yes 23 0.000562581847946628 31 7465181 SGTC_281 1672-3440 14.9 µM 3.24732739588486 0.000703085032685991 yes 24 0.000582471497721843 19 6833000 SGTC_2469 5655019 90.81 µM 3.16031476903791 0.000941890344686585 yes 25 0.000787993888553633 47 2788239 SGTC_1680 diphenhydramine 100 µM 3.14791729274603 0.000981416618369804 yes 26 0.000822191062582826 67 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3054 9094397 49.47 µM 3.14587183027911 0.000988082538831421 yes 27 0.000827962779042585 68 2598354 SGTC_78 0336-0123 156.75 µM 3.13300915156661 0.00103096175826166 no 28 0.00086512023659628 47 6765896 SGTC_3077 9117319 49.47 µM 3.12294290512433 0.00106570222423134 no 29 0.000895262392086307 37 17154678 SGTC_309 k408-0051 1.48 µM 3.11688280979478 0.00108713106212371 no 30 0.00091387106061501 110 3640463 SGTC_2801 7907800 81.82 µM 3.10250819862974 0.00113954936523725 no 31 0.000959441163498698 69 6620925 SGTC_167 3672-0051 66.205 µM 3.06237446996862 0.00129839458794713 no 32 0.00109794277982696 81 3237971 SGTC_656 4090-1979 187 µM 3.04343868126112 0.00138015734390686 no 33 0.00116945551014787 58 22330961 SGTC_1252 0493-0875 34.8 µM 3.04043374449175 0.00139355644334698 no 34 0.00118118831105105 72 3960963 SGTC_2892 9047358 58.44 µM 2.98364987455468 0.00167014994505714 no 35 0.00142416250218798 28 6466771 SGTC_166 k072-0058 166.424 µM 2.97815133698546 0.00169942898352762 no 36 0.00144996379576838 83 5846229 SGTC_1246 0422-0085 105 µM 2.97133966341037 0.00173634805438287 no 37 0.00148251825538172 85 264295 SGTC_3325 9138760 55.175 µM 2.94619629821214 0.00187903095843541 no 38 0.00160854083052828 62 43844959 SGTC_787 4152-0075 138 µM 2.93155966507811 0.00196691863195055 no 39 0.00168632286799249 59 9566539 SGTC_1682 st012968 530 nM 2.91995865291005 0.00203921267334241 no 40 0.00175038914727291 62 24207270 SGTC_1098 clofazimine 15.1 µM 2.90637811520264 0.00212690123072952 no 41 0.00182819658100173 88 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_416 estradiol valerate 100 µM 2.89839742612536 0.00218001360061108 no 42 0.00187537487055771 50 13791 A steroid. SGTC_708 3448-5400 146 µM 2.89519369576083 0.00220167087935983 no 43 0.0018946231853882 106 3462195 SGTC_3107 9121808 49.47 µM 2.88898091364292 0.00224422601238333 no 44 0.00193246266160624 31 662681 SGTC_2658 polymyxin b sulfate 77.05 µM 2.88558563241336 0.00226779599763766 no 45 0.00195343080939494 92 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_541 4513-1321 94 µM 2.86230782932079 0.00243552167189293 no 46 0.00210284107477158 78 747515 SGTC_723 4182-0001 115 µM 2.85722659849726 0.0024735940071124 no 47 0.0021368031249332 64 744821 YLR208W SEC13 SGTC_1085 doxorubicin 7.67 µM 2.82699090811367 0.00271148421431175 no 48 0.00234938309741071 78 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_98 0074-0023 107.663 µM 2.81693719352982 0.0027950464257343 no 49 0.00242420028932313 98 3563821 SGTC_2572 astragaloside iv 100 µM 2.80430916881067 0.00290329419732709 no 50 0.00252122636696155 93 45006101 An anti-inflammatory agent. SGTC_1449 4112-4002 201 µM 2.80085820556081 0.00293352632948462 no 51 0.00254834540196996 62 2059539 SGTC_1867 st057372 64 µM 2.77488886749094 0.003170285914876 no 52 0.00276102868875615 56 688837 SGTC_2433 5607874 27.82 µM 2.76476537968091 0.00326714528067756 no 53 0.00284818754072997 89 2252428 SGTC_3314 9135860 59.4275 µM 2.75042364919654 0.00340892098705231 no 54 0.00297591299798882 74 25252478 SGTC_2183 6420625 130.508 µM 2.74014658349843 0.00351389008153154 no 55 0.00307058943080329 149 2897619 SGTC_2268 7933382 153.85 µM 2.73359720273943 0.00358229019282239 no 56 0.00313233146527715 106 935025 YOR257W CDC31 SGTC_652 0437-0092 114 µM 2.6869954616934 0.00410449381745178 no 57 0.00360489661635753 71 3091274 SGTC_380 3970-0968 6 µM 2.65075800375328 0.00455657794704748 no 58 0.00401556808103663 85 2891601 SGTC_997 3996-0078 137 µM 2.65059125866497 0.00455875708161482 no 59 0.00401755084081655 120 735687 SGTC_695 3505-6186 243 µM 2.64400227806481 0.00464561438590257 no 60 0.00409660523677411 87 1819379 SGTC_2553 4-methylesculetin 85.09 µM 2.60515365348713 0.00518839535620901 no 61 0.00459165332128021 109 5319502 SGTC_2837 9008476 45.46 µM 2.58574306388918 0.00548017986284853 no 62 0.00485846670522839 135 2992805 SGTC_1360 1598-0022 39.8 µM 2.585067294352 0.00549059578115876 no 63 0.00486799965029862 157 761525 SGTC_1170 0310-0127 64.8 µM 2.57594629449022 0.00563291250045153 no 64 0.00499830859591987 116 774975 SGTC_906 1165-0455 526 µM 2.56843981387943 0.00575248490375511 no 65 0.0051078725140592 65 3252859 SGTC_2412 st077135 33.4 µM 2.56736702916427 0.00576975624117887 no 66 0.00512370415974098 122 13258915 SGTC_2339 9000433 200 µM 2.56041310883869 0.00588283127603873 no 67 0.00522739019163504 124 2988954 SGTC_624 k048-0052 28 µM 2.53110659565367 0.00638126056421103 no 68 0.00568516438803098 106 6835531 SGTC_1326 1431-2094 10.8 µM 2.52766149222419 0.00644224141720093 no 69 0.00574125012411031 116 616278 SGTC_3241 9133421 49.47 µM 2.52064376421068 0.00656805732983576 no 70 0.0058570188019328 32 17018221 SGTC_932 2857-0803 154 µM 2.49377339551755 0.00707011262695724 no 71 0.00631966031016466 109 674898 SGTC_1825 st052143 62.6 µM 2.49166253385914 0.0071109510736294 no 72 0.00635733891871755 90 674173 SGTC_2750 bromebric acid 70.15 µM 2.4882449080232 0.0071775125961064 no 73 0.0064187647603551 143 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_958 1222-0007 33 µM 2.47842165715056 0.00737189937898135 no 74 0.00659825440884253 143 7312461 SGTC_1349 flufenamic acid 69 µM 2.47135846141378 0.00751452210063366 no 75 0.00673004109473696 105 3371 A non-steroidal anti-inflammatory. SGTC_557 1315-0110 16.2 µM 2.46396535079692 0.00766640464711989 no 76 0.00687046970726111 137 6833801 SGTC_3236 9132701 49.47 µM 2.46109698859796 0.00772605541230634 no 77 0.00692564580267731 113 24282524 SGTC_2940 9060638 45.86 µM 2.45611594889152 0.00783061268599649 no 78 0.00702239168030395 147 4027022 SGTC_1514 1189-1591 158 µM 2.45490979101373 0.00785611766052472 no 79 0.00704599731220449 163 767698 YMR146C TIF34 SGTC_2464 5717415 7.67 µM 2.44202588861686 0.00813314846963828 no 80 0.0073025496186253 114 5285744 SGTC_952 1185-0122 232 µM 2.43412086560206 0.00830734050562054 no 81 0.00746400472179036 125 678600 SGTC_1757 st041620 31.8375 µM 2.43376985846574 0.00831515056204623 no 82 0.00747124618316988 138 5289815 SGTC_830 4076-0286 57.8 µM 2.40958999069111 0.00886892292063306 no 83 0.00798522846447957 259 6866659 SGTC_2066 5222451 176 µM 2.40561313160713 0.00896303195464488 no 84 0.00807267605083563 176 2281147 SGTC_1769 st044406 64.4 µM 2.39461018196799 0.00922798045243009 no 85 0.00831902183182309 126 670903 SGTC_2845 9003024 42.97 µM 2.3905195842982 0.00932821494590614 no 86 0.00841227590787188 183 2990173 SGTC_1356 1502-0781 85.8 µM 2.37370289949077 0.00975035918074886 no 87 0.00880535717521285 133 567702 SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.37191109261702 0.00979630747558388 no 88 0.00884817418216334 120 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1620 st003704 16.5 µM 2.34743213283299 0.0104432351987503 no 89 0.00945165828367664 105 2834414 SGTC_3055 9094636 49.47 µM 2.34444071690295 0.0105247903771597 no 90 0.00952781980766638 117 25236176 SGTC_584 0986-0246 15.4 µM 2.31924676759295 0.0112339524077581 no 91 0.0101908299836341 137 53315 YDR232W HEM1 SGTC_1132 3456-3614 2.5 µM 2.30632027843681 0.0116136735116966 no 92 0.0105463714343143 225 3125502 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.30160716266109 0.0117548697646746 no 93 0.010678667923412 119 229346 A bile salt which induces apoptosis. SGTC_2293 7624732 200 µM 2.2973140517191 0.0118847776036745 no 94 0.0108004303870911 147 894453 SGTC_2235 salicylic acid 500 µM 2.29573643414207 0.0119328276514062 no 95 0.0108454779524601 72 338 A COX inhibitor and kinase inhibitor. SGTC_1667 st014849 34.6 µM 2.29317600287027 0.0120111702695695 no 96 0.0109189370643935 122 5348460 SGTC_1218 1348-1416 30.7 µM 2.28677337136171 0.0122090292309022 no 97 0.0111045272686237 144 6787668 SGTC_1906 st060206 94.7 µM 2.27758186693187 0.0124980074666941 no 98 0.0113757509418416 162 5133468 SGTC_823 0417-1665 178 µM 2.27148586971271 0.0126929140313572 no 99 0.0115587907044173 165 3429856 SGTC_2906 7926292 26.41 µM 2.26751478180921 0.0128212912112126 no 100 0.011679398472835 177 2966319 SGTC_1284 0929-0043 16 µM 2.26089685251118 0.013037731363124 no 101 0.0118828225421008 153 1239883 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.25532682617925 0.0132223405597185 no 102 0.0120564109953695 152 2333 A French combination drug. SGTC_697 0508-1955 564 µM 2.25353101219573 0.0132823392714317 no 103 0.0121128438100775 190 6243113 SGTC_885 0865-0106 16.8 µM 2.2350901051036 0.0139121859863873 no 104 0.0127057169292344 189 2793380 SGTC_3143 9086658 49.47 µM 2.234350074144 0.0139379902221475 no 105 0.0127300239843229 223 25236626 SGTC_1725 st036284 20.55 µM 2.22258511174478 0.0143538004019113 no 106 0.0131218945276534 197 707914 SGTC_3187 9109394 49.47 µM 2.2112784198381 0.0147634358618435 no 107 0.0135082813994155 184 17098090 SGTC_1897 st060201 15 µM 2.20842727683044 0.0148683049050741 no 108 0.0136072510481498 156 611878 SGTC_838 0109-0203 71.4 µM 2.19491341690512 0.0153741201294113 no 109 0.0140849046000757 151 759422 SGTC_702 1488-0190 94 µM 2.19171837639348 0.0154958454448019 no 110 0.0141999240015736 133 949357 SGTC_1094 duloxetine 25.4 µM 2.19087626868853 0.0155280656578121 no 111 0.0142303737436258 183 60834 A selective serotonin reuptake inhibitor. SGTC_2369 9071472 200 µM 2.1895314589386 0.0155796391829458 no 112 0.0142791173044248 173 17296037 SGTC_2005 4024620 188 µM 2.18692173756649 0.0156801416457175 no 113 0.0143741188784192 168 236743 SGTC_2810 7959871 45.46 µM 2.1844965053395 0.0157740374029914 no 114 0.0144628918982597 224 2974535 SGTC_1078 idebenone 36.1 µM 2.18181920804447 0.0158782518079992 no 115 0.0145614391918229 257 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1070 indatraline 8.81 µM 2.17226664384512 0.0162549123359315 no 116 0.0149177782307357 171 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3258 9138477 49.47 µM 2.15761912828971 0.0168473248593859 no 117 0.0154787281267475 151 4970355 SGTC_2446 5162541 200 µM 2.15196991400077 0.0170806891868404 no 118 0.0156998620150666 160 1549321 SGTC_368 fentichlor 4.58 µM 2.14652947754164 0.0173080350597476 no 119 0.0159153797862452 165 7329 A pesticide. SGTC_2123 5259487 200 µM 2.13861052100632 0.017643570233584 no 120 0.016233612358043 182 2173474 SGTC_2203 7227154 166.4 µM 2.13304445731898 0.017882719335497 no 121 0.0164605397068796 150 896304 SGTC_994 3910-0338 138 µM 2.13194491215256 0.0179302875166349 no 122 0.0165056877412554 215 3479481 SGTC_2968 9090663 33.37 µM 2.13094583029919 0.0179736030106312 no 123 0.0165468025612159 206 25236811 SGTC_3115 9123671 49.47 µM 2.10119108070874 0.0193051413984508 no 124 0.0178120980261835 129 3286988 SGTC_3205 9113483 49.47 µM 2.09806467943133 0.0194497963552128 no 125 0.0179497160780782 237 17018033 SGTC_2232 chlorophetanol 41.5365 µM 2.09585457282766 0.0195526100639447 no 126 0.0180475467700553 324 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.09331529513278 0.0196713061983349 no 127 0.0181605090888929 293 6708739 YPR165W RHO1 SGTC_328 k915-0120 63.5 µM 2.08721483230113 0.0199589692413296 no 128 0.018434359659335 181 6624543 SGTC_2688 kanamycin b 96.69 µM 2.08650343982299 0.019992745663278 no 129 0.0184665219701941 766 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1068 loratadine 26.9 µM 2.07310012097532 0.0206382463755064 no 130 0.0190814813811504 194 3957 A H1 histamine antagonist. SGTC_1101 ebselen 5.29 µM 2.0717082388284 0.0207062797602851 no 131 0.0191463292704665 202 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1341 1486-1360 280 µM 2.07015181466646 0.0207825805824826 no 132 0.0192190649815941 206 3976547 SGTC_88 0180-0332 8.668 µM 2.06791269336892 0.0208927668776583 no 133 0.0193241167969591 198 3101745 SGTC_2334 9017922 200 µM 2.0647711372209 0.0210481949719196 no 134 0.0194723300151757 173 3163164 SGTC_3208 9114115 49.47 µM 2.05979410619532 0.0212964353735926 no 135 0.0197091141330591 233 650895 SGTC_2407 paclitaxel 400 µM 2.05800885704213 0.0213860798705724 no 136 0.0197946415942177 242 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2204 7233102 200 µM 2.03766273951031 0.0224304728501361 no 137 0.0207918364669077 140 2172480 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.02188044379818 0.0232699325591491 no 138 0.0215943522766411 234 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3276 9139060 49.47 µM 2.02107600659528 0.0233134195378761 no 139 0.021635948831528 144 4870619 SGTC_1722 st034304 3.6505 µM 2.02043707043987 0.0233480084339107 no 140 0.0216690357357535 240 4036148 YLR033W RSC58 SGTC_1672 st016598 6.51 µM 2.01500982112478 0.0236435583876932 no 141 0.0219518100199328 270 4665860 YNL267W PIK1 SGTC_967 1306-0166 352 µM 2.01338853666225 0.0237324561379261 no 142 0.0220368853098061 233 4437607 SGTC_2161 5662504 8.5105 µM 2.01063612289568 0.0238840191244933 no 143 0.022181952811115 210 2859334 SGTC_3206 9114350 49.47 µM 2.00910878959847 0.0239684728847537 no 144 0.0222627988561686 201 17087243 SGTC_764 1951-2361 146 µM 2.00442987978495 0.024228756239946 no 145 0.022512015621852 227 5438930 SGTC_2726 cimetidine 79.27 µM 2.00355732403044 0.0242775573877547 no 146 0.0225587506026741 136 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1102 cgs 12066b 26.1 µM 1.99865107639635 0.0245534981929101 no 147 0.0228230599452546 180 6438352 A 5-HT1B full agonist. SGTC_1880 MG-132 525 µM 1.99614836151222 0.0246952685129575 no 148 0.0229588881387064 184 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1331 1472-0049 76.2 µM 1.99285744799125 0.0248827322686302 no 149 0.0231385294887176 232 24051409 SGTC_1483 3453-0561 55.9 µM 1.98794127655004 0.025164999241398 no 150 0.0234090924913259 245 4546991 SGTC_1197 1601-0112 267 µM 1.9853552199346 0.0253145542191844 no 151 0.0235524821928201 250 7350313 SGTC_2441 5730946 39.09 µM 1.98080767384003 0.0255793505822591 no 152 0.0238064229569764 238 1774275 SGTC_471 1-acyl-paf 4 µM 1.97987376484734 0.0256340166807075 no 153 0.0238588575154016 225 16759367 SGTC_1319 1306-0155 43.7 µM 1.97483887980214 0.0259304199262735 no 154 0.0241432176463182 273 3122360 SGTC_1539 benzyladenosine 56 µM 1.97350612341921 0.0260093574001615 no 155 0.0242189638020097 192 92208 A nucleotide analog. SGTC_1573 oleylamine 1.06 µM 1.97023191405379 0.0262041385229776 no 156 0.0244058987616975 258 5356789 An amine of the fatty acid oleic acid. SGTC_2445 5742597 35.57 µM 1.96077407984037 0.0267736416176472 no 157 0.0249526914959583 214 1774255 SGTC_2694 st077685 81.9 µM 1.95831509874586 0.0269233905112488 no 158 0.0250965250904349 258 2838096 SGTC_1783 st039459 87.517 µM 1.95145496984973 0.0273448641708871 no 159 0.0255014739396839 267 729761 SGTC_1964 st076914 61 µM 1.94988849427333 0.0274418734031511 no 160 0.025594705395131 200 24208661 SGTC_1991 st073000 8.92 µM 1.94621570421766 0.0276704487897665 no 161 0.0258144171390658 317 4301969 YIL048W NEO1 SGTC_864 0469-0573 172 µM 1.94166344758021 0.0279559576141663 no 162 0.0260889282349122 222 689425 SGTC_1239 0337-0584 35.4 µM 1.92610311818444 0.0289504600862872 no 163 0.0270457496823573 305 914301 YML130C ERO1 SGTC_657 3534-0529 86.7 µM 1.91018163711286 0.0299983033796916 no 164 0.0280549153148932 239 1049549 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.90947855662761 0.0300452911367843 no 165 0.028100192686986 299 442882 SGTC_254 nsc-64875 3.808 µM 1.89835992452413 0.0307965120088662 no 166 0.0288243425022969 213 56993 SGTC_394 menadione 8.33 µM 1.8970381031412 0.0308868450791265 no 167 0.0289114546883342 244 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2237 6667747 47.222 µM 1.89574264768516 0.0309755889907663 no 168 0.0289970414858109 217 729940 YDL015C TSC13 SGTC_573 3702-0553 84.7 µM 1.88025255832533 0.0320531613931494 no 169 0.0300368328215899 240 1222756 SGTC_1445 4239-0156 97.7 µM 1.87985801850871 0.032081006854674 no 170 0.0300637153776867 296 4008346 SGTC_1233 0325-0408 14.2 µM 1.8785522522556 0.0321733064680227 no 171 0.0301528280001577 260 12874 SGTC_100 0086-0128 49.5915 µM 1.87422348188184 0.0324808598068319 no 172 0.030449814452703 331 93297 SGTC_192 3455-0609 60.9 µM 1.8734305020018 0.0325374619736186 no 173 0.0305044806516945 241 3769639 SGTC_913 3487-1245 167 µM 1.86270202368362 0.0333112788766502 no 174 0.0312521005081547 288 4016153 SGTC_333 3486-0131 40.1 µM 1.85249810627425 0.0340612612232934 no 175 0.0319771646214924 253 6744690 SGTC_1662 st014054 52 µM 1.8502665040656 0.034227119596829 no 176 0.032137573947554 201 2838777 SGTC_2903 5923464 63.88 µM 1.84418569187362 0.0346824326619129 no 177 0.0325780414220745 208 2876576 SGTC_2665 lovastatin 100 µM 1.84009641363215 0.0349914139912834 no 178 0.0328770418694832 259 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3356 9151811 4.48 µM 1.83764862778656 0.035177444431158 no 179 0.0330570991717306 271 1859254 YPR165W RHO1 SGTC_3227 9130768 49.47 µM 1.83647113844551 0.0352672216219276 no 180 0.0331440034158828 202 17720899 SGTC_2236 dapsone 200 µM 1.83233415243321 0.0355841356898801 no 181 0.033450825916305 264 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_71 0417-1750 47.813 µM 1.82001567487211 0.0365416422445366 no 182 0.0343783089268378 323 6811472 SGTC_483 fpl-64176 144 µM 1.81966284841929 0.036569374732176 no 183 0.0344051821484216 186 3423 SGTC_194 1486-1323 56.904 µM 1.81865870072036 0.036648395927194 no 184 0.0344817580940634 257 5178754 SGTC_567 1080-0542 68.4 µM 1.81084877005022 0.0372677759011213 no 185 0.0350821322780787 240 5950415 SGTC_1397 3532-0190 20.1 µM 1.80972579038997 0.0373575349632871 no 186 0.0351691604960515 205 5322280 SGTC_1484 3473-2379 286 µM 1.79918297485669 0.038208855468735 no 187 0.0359948708248473 323 671917 SGTC_712 r015-0009 80.6 µM 1.79838809793216 0.0382736771111699 no 188 0.0360577637772799 247 6813872 YLR060W FRS1 SGTC_2909 7941780 10.49 µM 1.79769568498575 0.0383302159385709 no 189 0.0361126228021622 278 1243215 SGTC_1046 2001-0062 216 µM 1.7920626234997 0.038792716938329 no 190 0.0365614676012944 293 739778 SGTC_2241 6772625 37.8075 µM 1.79157570073509 0.0388329081434643 no 191 0.0366004792017722 288 2285411 SGTC_840 0245-0196 390 µM 1.79065122718452 0.0389093086506357 no 192 0.0366746404880706 316 3827528 SGTC_2731 amoxapine 43.43 µM 1.7900713957615 0.0389572896145952 no 193 0.0367212172663251 130 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1986 st071812 45 µM 1.78574876336175 0.0393165070925534 no 194 0.0370699730085364 229 11838594 SGTC_1038 k292-0204 154 µM 1.78455635789185 0.0394160707423273 no 195 0.0371666528303797 287 4454212 SGTC_79 0052-0007 94.094 µM 1.77839882720729 0.0399334824898294 no 196 0.0376691875883451 295 2801472 SGTC_1016 4226-1401 38 µM 1.77529008485628 0.0401967966898404 no 197 0.0379250008571566 314 2901613 SGTC_2540 epiandrosterone 100 µM 1.77315157883166 0.0403787482004286 no 198 0.0381017965593203 403 441302 A steroid. SGTC_2748 diazoxide 86.69 µM 1.77309089264223 0.0403839213346442 no 199 0.0381068234325133 217 3019 A potassium channel activatior. SGTC_2421 5690543 90.72 µM 1.77122601286507 0.0405431537185072 no 200 0.0382615625914063 293 3397993 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.77099833095042 0.0405626291563285 no 201 0.0382804896364209 295 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2785 7756463 72.73 µM 1.76768968593477 0.0408465017300339 no 202 0.0385563976020492 289 2201551 SGTC_306 1672-3436 11.6 µM 1.75790879571991 0.0416951106665894 no 203 0.0393815144980348 295 6797378 SGTC_626 0214-0009 33 µM 1.75400687804793 0.0420376088462401 no 204 0.0397146643011447 300 3437874 SGTC_2428 5615643 7.78 µM 1.75141382510055 0.0422664759284389 no 205 0.0399373266434105 307 2253075 SGTC_40 0327-0103 19.753 µM 1.74468849284999 0.0428647652284382 no 206 0.0405195537110553 310 409036 SGTC_2311 7694451 200 µM 1.74363199651277 0.0429593707758492 no 207 0.0406116401281443 313 2163142 SGTC_283 0987-0079 11.7 µM 1.74259665511148 0.0430522455824762 no 208 0.0407020473623906 341 411556 SGTC_2037 5169046 200 µM 1.74257484555003 0.0430542037418834 no 209 0.0407039535541155 285 5718022 SGTC_233 rapamycin 362 pM 1.73897324573935 0.0433785597161096 no 210 0.0410197345248647 297 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2300 7976697 71.57 µM 1.73570422884567 0.0436746689818472 no 211 0.0413080726958214 268 2236109 SGTC_3245 9134821 49.47 µM 1.72298904894877 0.0448419598012558 no 212 0.0424452527087957 347 17014901 SGTC_1496 4469-0713 57.4 µM 1.72298555975746 0.0448422835329903 no 213 0.0424455682041997 305 746691 SGTC_1369 1866-0067 208 µM 1.72034197539071 0.0450881000586232 no 214 0.0426851488209017 373 3531355 SGTC_3046 9092212 49.47 µM 1.71905091760692 0.0452085439610127 no 215 0.0428025504539556 277 25236637 SGTC_598 3937-0236 20.2 µM 1.71121500329189 0.0459451269406142 no 216 0.0435207150194034 366 1379313 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.70848078935594 0.0462044034383782 no 217 0.0437735839809728 302 688798 SGTC_2181 6316240 54.2555 µM 1.69763814875633 0.0472441643807391 no 218 0.0447880390213849 295 12779990 SGTC_1199 1638-0010 4.46 µM 1.69465086280982 0.0475339033663268 no 219 0.0450708361035768 364 3111136 SGTC_1226 3909-7979 35.4 µM 1.68812999204174 0.0481713122364412 no 220 0.0456931391419398 378 6615510 SGTC_1583 clindamycin 39.6 µM 1.68719996719966 0.0482627759602057 no 221 0.0457824538599274 312 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2727 riluzole 51.77 µM 1.68259700093224 0.0487175040090903 no 222 0.0462265663359655 289 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_554 4483-2211 187 µM 1.67537203643769 0.0494381593883005 no 223 0.0469306298105227 339 747107 SGTC_698 k064-0052 127 µM 1.6749440179976 0.0494811177463325 no 224 0.0469726080153736 245 5088751 SGTC_691 1548-0686 185 µM 1.67283445347329 0.0496932810862054 no 225 0.0471799451281542 380 46495133 SGTC_3052 9092717 49.47 µM 1.67236513916967 0.0497405795713868 no 226 0.0472261709772071 340 25237534 SGTC_1073 triclabendazole 3.09 µM 1.66976924040925 0.0500028488269372 no 227 0.0474825142030478 388 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1912 st060209 90.8 µM 1.6692928714891 0.0500510969412399 no 228 0.0475296761381103 339 688787 SGTC_2797 7859098 81.82 µM 1.66782562209049 0.0501999377656047 no 229 0.0476751740036058 356 972681 SGTC_1382 3002-2117 298 µM 1.66361728291752 0.0506287982944174 no 230 0.0480944679223732 342 1497314 SGTC_406 estrone 100 µM 1.65906960877963 0.0510955148657075 no 231 0.0485508832328968 336 5870 A steroid. SGTC_1851 st056236 18.9 µM 1.65607009061458 0.051405217442978 no 232 0.0488538127500215 335 5393171 SGTC_431 k089-0097 107 µM 1.65513863605706 0.0515016940735775 no 233 0.0489481896208238 417 5499420 SGTC_3074 9116018 49.47 µM 1.65194541340282 0.0518335296427188 no 234 0.0492728395666505 300 17027303 SGTC_326 k292-0812 17.5 µM 1.64884794305005 0.0521570361199491 no 235 0.0495893950725433 296 3579357 SGTC_2705 st078069 42.8 µM 1.64786026181825 0.0522605282227388 no 236 0.0496906747647027 317 1530061 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.64158594334274 0.0529217830228444 no 237 0.0503379213676741 377 688667 SGTC_571 k831-0106 44.2 µM 1.64117338966928 0.0529654938155057 no 238 0.0503807139248112 314 4783639 SGTC_489 paxilline 115 µM 1.63777543308028 0.0533266033462873 no 239 0.0507342740770322 325 105008 A toxic potassium channel blocker. SGTC_1444 4112-3581 28 µM 1.637222120373 0.0533855896140461 no 240 0.0507920333370015 333 2877249 SGTC_726 3448-4391 34.2 µM 1.63491345902655 0.0536322641439044 no 241 0.0510335953118376 377 1356692 SGTC_504 lovastatin 124 µM 1.62982144505075 0.0541795243642987 no 242 0.0515696200001398 291 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_99 0109-0120 622.8 µM 1.62658023427153 0.054530166374128 no 243 0.0519131400360382 307 759414 SGTC_1255 0566-0045 221 µM 1.62203298592989 0.0550251209727158 no 244 0.0523981427396927 379 2788469 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.62052801464041 0.0551897122604733 no 245 0.052559450725095 631 16725076 SGTC_3223 9129970 49.47 µM 1.61926840158296 0.0553277686741036 no 246 0.0526947631451474 384 17248386 SGTC_2194 5927483 104.545 µM 1.61895518597863 0.055362140110388 no 247 0.0527284528318571 386 760979 SGTC_444 curcumin 90.4 µM 1.61483109761491 0.05581628075814 no 248 0.0531736383840356 389 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3117 9124945 49.47 µM 1.61082920332222 0.0562597705557061 no 249 0.0536084770542944 291 17592065 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.60941959409873 0.056416643362368 no 250 0.0537623118247776 403 6708561 SGTC_1159 4092-0538 61.2 µM 1.59944850775297 0.0575361721313432 no 251 0.0548604906734534 400 717301 SGTC_2687 chenodiol 100 µM 1.59895417825025 0.057592125614986 no 252 0.0549153922090715 347 5702181 A cholesterol synthesis inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 1.59218705876119 0.0583624107611425 no 253 0.0556713400730048 362 16667744 Haematoxylin. SGTC_2556 citropten 84.59 µM 1.59151947942121 0.0584388361602407 no 254 0.0557463575658835 426 2775 A potential DNA crosslinker. SGTC_3200 9114385 49.47 µM 1.58948482008472 0.0586722516127981 no 255 0.0559754892477146 348 17018030 YLR208W SEC13 SGTC_3192 9110362 49.47 µM 1.58521339475908 0.0591646485397372 no 256 0.0564589290862653 373 16649480 SGTC_1646 st011709 75.6 µM 1.58365291750341 0.0593453417736308 no 257 0.0566363623205892 328 5757843 SGTC_1651 st011928 86.1 µM 1.58325621169632 0.0593913466635579 no 258 0.0566815395083329 347 720198 SGTC_2000 st075254 36.4 µM 1.58046484727871 0.0597158444994709 no 259 0.0570002255366929 324 17234175 SGTC_1043 0916-0009 19.3 µM 1.57943545796228 0.0598358616418521 no 260 0.0571181048460741 471 3101130 SGTC_1433 4060-0023 7.6 µM 1.57934695621948 0.0598461889297437 no 261 0.0571282484709709 375 3840627 SGTC_321 4534-3890 65.3 µM 1.57740242795726 0.0600734488965366 no 262 0.0573514785659078 351 699746 SGTC_1500 4488-1866 171 µM 1.57529490596244 0.0603205206660026 no 263 0.057594194632021 416 2900003 SGTC_2212 7123476 200 µM 1.57336003933804 0.0605480510647948 no 264 0.0578177372045398 275 1085715 SGTC_3171 9103192 49.47 µM 1.56893228782622 0.0610712581243463 no 265 0.0583318587501103 322 13018434 SGTC_3070 9117005 49.47 µM 1.5667846290008 0.061326306575536 no 266 0.0585825207164088 286 8779016 SGTC_2420 aureobasidin a 50 nM 1.56571878062292 0.0614531915937204 no 267 0.0587072337908232 442 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2130 NSC 7 2.4545 µM 1.56234154881066 0.0618565921795725 no 268 0.0591037744727785 414 21448 SGTC_15 0266-0086 27.098 µM 1.55898957879426 0.062259016113554 no 269 0.0594994233540453 482 1712902 YIL048W NEO1 SGTC_3066 9117245 49.47 µM 1.55852871106181 0.0623145053447695 no 270 0.059553983709634 388 17176980 SGTC_2889 9059656 51.95 µM 1.55826923284338 0.0623457639147704 no 271 0.0595847195851308 411 3949838 SGTC_1317 1273-0028 910 nM 1.55759973977222 0.0624264722338036 no 272 0.0596640802132254 382 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2010 4012422 159 µM 1.55357319792988 0.0629135969957576 no 273 0.060143128297869 397 952393 SGTC_1559 coumarin 343 70.1 µM 1.55301857187382 0.0629809262041846 no 274 0.0602093488947486 329 108770 A hepatotoxic, DNA x-linker. SGTC_559 1550-0661 158 µM 1.55088545395027 0.0632404006873792 no 275 0.0604645684589848 376 5830875 SGTC_1428 4049-0204 61.7 µM 1.54755058453555 0.0636477242272244 no 276 0.0608652683243244 399 X1428 SGTC_1847 st056231 15 µM 1.54736538252755 0.063670404633039 no 277 0.0608875819058002 474 5393180 SGTC_1299 1079-1439 3.74 µM 1.54595704997677 0.06384307912054 no 278 0.0610574704871541 373 323161 SGTC_2629 bisabolol 100 µM 1.5446133278443 0.0640081711164424 no 279 0.0612199102376295 424 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_335 4077-0256 27.6 µM 1.54450282704592 0.0640217621908146 no 280 0.0612332834601236 453 3121989 SGTC_89 0302-0250 142.109 µM 1.54077358901465 0.0644817577636155 no 281 0.0616859497361504 430 4203518 YLR208W SEC13 SGTC_677 0929-0063 136 µM 1.54072315016217 0.0644879968687647 no 282 0.0616920900168541 321 1539583 SGTC_3146 9095609 49.47 µM 1.53886655959059 0.0647179769719654 no 283 0.0619184382402159 380 17173999 SGTC_2142 5622915 118.518 µM 1.53861448220323 0.0647492514206738 no 284 0.0619492204342847 356 5322196 SGTC_2878 9043973 25.97 µM 1.53830808399663 0.0647872810830095 no 285 0.0619866520428777 351 6465167 SGTC_3079 9117512 49.47 µM 1.53361161285094 0.0653723724151425 no 286 0.0625626148418901 340 7185044 SGTC_2655 perillic acid 100 µM 1.5307079740929 0.0657361559983032 no 287 0.0629207910609834 331 5702197 An apoptosis inducer. SGTC_2961 9083290 32.55 µM 1.52764251159617 0.0661219145766645 no 288 0.0633006603671081 366 17741490 SGTC_2760 etidronate 98.04 µM 1.52265213870531 0.0667536524965418 no 289 0.0639228790273 414 3305 A chelator and antioxidant. SGTC_2113 5491891 107.031 µM 1.52012593383059 0.0670752236147599 no 290 0.064239663904448 432 789979 SGTC_1021 4476-0760 85.3 µM 1.51796236208536 0.0673515849159896 no 291 0.0645119436137277 428 746768 SGTC_1473 k844-0725 134 µM 1.51783324815692 0.0673681049206241 no 292 0.0645282205601233 456 54682906 SGTC_828 2074-0507 139 µM 1.51654494942079 0.0675331131061281 no 293 0.0646908067066615 439 X828 SGTC_3023 9089636 49.47 µM 1.50601957331487 0.0688929483815489 no 294 0.066031074540835 407 17249241 SGTC_641 4092-0595 30 µM 1.50022459386685 0.0696505933732909 no 295 0.0667781173108013 442 786260 SGTC_544 k015-0020 52.4 µM 1.4968499574142 0.0700947448909349 no 296 0.0672161519334412 396 3008304 SGTC_2256 7954252 200 µM 1.49655588235955 0.0701335524409321 no 297 0.0672544284544131 329 2972920 SGTC_2972 9093619 59.92 µM 1.49492964603525 0.0703484568299687 no 298 0.0674664021130529 425 25236256 SGTC_3231 9132313 49.47 µM 1.49380047960368 0.0704979718703298 no 299 0.0676138880797377 420 4905967 SGTC_1636 st007707 68.9 µM 1.48953322036533 0.0710652143145673 no 300 0.0681735060954615 485 403051 SGTC_2150 5556613 200 µM 1.48617867250075 0.0715135865399222 no 301 0.0686159336147764 461 743190 SGTC_989 1501-0895 10.3 µM 1.48615133597924 0.071517249263222 no 302 0.0686195480725448 393 2830112 SGTC_2902 5787006 60.46 µM 1.48449127283462 0.0717399451301767 no 303 0.0688393183563236 425 591003 SGTC_1187 1391-0724 117 µM 1.48355518219405 0.0718657551085245 no 304 0.0689634833593715 467 6997986 SGTC_1482 3346-2049 8.48 µM 1.48158659108279 0.0721308844680625 no 305 0.069225164524893 418 3826804 SGTC_2825 7998094 58.44 µM 1.48067919265253 0.0722533448234236 no 306 0.0693460405970089 419 2987815 SGTC_843 0310-0051 143 µM 1.47837862592163 0.0725645379395824 no 307 0.0696532315677107 424 2065037 SGTC_2426 5582046 32.21 µM 1.47334196342199 0.0732494202755669 no 308 0.0703294254524578 463 2251934 SGTC_1111 tnp00062 510.699 nM 1.47051662172535 0.0736357676632156 no 309 0.0707109436404243 418 676306 SGTC_523 1934-0222 13.7 µM 1.45833248205406 0.0753197354636382 no 310 0.0723744605662571 462 1361595 SGTC_2476 5806916 10.51 µM 1.45695088005527 0.0755125247089717 no 311 0.0725649698438448 412 2870194 SGTC_1992 st073643 23.3 µM 1.4449072987911 0.077209047558783 no 312 0.0742419629595635 431 3161292 SGTC_3199 9111318 49.47 µM 1.44426443204221 0.0773004127944181 no 313 0.0743323033627793 433 8548020 SGTC_1852 st056254 31.4 µM 1.44378295616682 0.077368894678509 no 314 0.074400018882058 442 442583 SGTC_3057 9095946 49.47 µM 1.4431650576541 0.0774568479046515 no 315 0.0744869900886174 437 24540043 SGTC_3124 9127567 49.47 µM 1.44192171698698 0.0776340582330805 no 316 0.0746622294724337 419 17592030 SGTC_1749 st037932 54.2 µM 1.43561967271908 0.0785370103770547 no 317 0.0755552968493298 447 594497 SGTC_2958 9077254 16.72 µM 1.43481222963829 0.0786532731967821 no 318 0.0756703059943082 418 16457351 SGTC_3354 9151612 71.43 µM 1.43218527646831 0.0790324277855075 no 319 0.0760454021452883 488 27261949 SGTC_1455 4262-0120 131 µM 1.4311042739873 0.0791888529319122 no 320 0.0762001662804681 454 1529587 SGTC_2065 5221596 34.26 µM 1.42891116725211 0.0795069238279799 no 321 0.0765148836680315 461 788581 SGTC_3053 9095903 49.47 µM 1.4255445132593 0.0799970766362417 no 322 0.0769999312300591 434 17174018 SGTC_1441 4106-0040 13 µM 1.42489792901912 0.0800914741345587 no 323 0.0770933541968185 445 2904180 SGTC_1765 st044815 90.4 µM 1.42417310952059 0.080197393601693 no 324 0.0771981835083338 458 645695 SGTC_2386 9075165 157.42 µM 1.41811280967537 0.081087145570109 no 325 0.078078915991604 426 16452277 SGTC_816 0325-0417 81.3 µM 1.40734559708256 0.0826862947712121 no 326 0.0796624673524169 440 68101 SGTC_293 4049-0273 38.5 µM 1.40714297309169 0.0827166144396043 no 327 0.0796924988043209 426 1380311 SGTC_865 0488-0499 301 µM 1.40243560363885 0.083423359389001 no 328 0.0803926038728135 513 9634651 SGTC_400 oxethazaine 37.5 µM 1.39733491727218 0.0841942682093232 no 329 0.0811564401942532 462 4621 A local anesthetic. SGTC_756 0508-1999 28.3 µM 1.3947267355262 0.084590524590697 no 330 0.0815491297283623 457 6753853 SGTC_2506 ethyl hematommate 54.16 µM 1.39347369460354 0.0847813935968997 no 331 0.0817382971473687 403 3940691 An allergen. SGTC_1770 st043884 66.3 µM 1.39341749364742 0.0847899619480173 no 332 0.0817467893629058 479 670149 SGTC_429 1112-0049 25.5 µM 1.38904947571179 0.0854578944586392 no 333 0.0824088529005434 459 2836170 SGTC_2266 7929956 200 µM 1.3887539716 0.0855032231858334 no 334 0.0824537880453021 512 2967153 SGTC_1154 4088-0362 150 µM 1.38795512017825 0.0856258527899022 no 335 0.0825753558647887 550 6618304 SGTC_755 1995-0008 37.3 µM 1.38692032120343 0.0857848978000403 no 336 0.0827330302815079 490 689533 SGTC_3134 9127454 49.47 µM 1.38667224983362 0.0858230583474203 no 337 0.0827708630639311 453 24262820 SGTC_66 0109-0187 42.4 µM 1.38614134042676 0.0859047702520953 no 338 0.0828518745521899 468 759417 SGTC_888 0916-0002 6.97 µM 1.38300773390766 0.0863882478312408 no 339 0.0833312472550914 490 2802138 YIL048W NEO1 SGTC_1668 st014914 51.6 µM 1.38289046359101 0.0864063806387697 no 340 0.0833492274169495 444 2839556 SGTC_1949 st076024 69.1 µM 1.38067367450794 0.086749685039077 no 341 0.0836896595801464 507 2921930 SGTC_2560 caryophyllene 100 µM 1.37561827119858 0.0875364043148865 no 342 0.0844699234644634 547 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2060 5238662 140 µM 1.37461338979054 0.0876934158202123 no 343 0.0846256676059682 482 790130 SGTC_3331 9141060 1.957 µM 1.3720431276258 0.0880959720415461 no 344 0.0850250061905325 474 4906567 YPR165W RHO1 SGTC_1017 4239-0030 168 µM 1.36723076116647 0.0888533900935848 no 345 0.0857764931540601 538 1149593 SGTC_2800 7887935 81.82 µM 1.36519588571514 0.0891751135558054 no 346 0.0860957455776692 481 2961002 SGTC_1525 8-methoxypsoralen 92.5 µM 1.35733354604128 0.0904263337849271 no 347 0.0873376264726804 567 4114 Related to psoralen; DNA damaging agent. SGTC_2280 7785178 200 µM 1.35711740390615 0.0904609140236417 no 348 0.0873719546735031 468 2954328 SGTC_935 2996-0153 430 µM 1.35628675621246 0.0905938994093196 no 349 0.0875039738217122 493 23738523 SGTC_473 2-arachidonoylglycerol 10 µM 1.3521276356636 0.0912619510869868 no 350 0.0881672440076494 509 5282280 An endocannabinoid. SGTC_3088 9117578 49.47 µM 1.35121578511125 0.0914089024853399 no 351 0.0883131597572652 483 678341 SGTC_629 3448-6466 76.7 µM 1.35100974968204 0.0914421308844899 no 352 0.0883461547809817 534 573744 SGTC_503 tyrphostin 8 294 µM 1.34897522390549 0.0917707302044215 no 353 0.0886724621505283 511 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1335 1486-0900 202 µM 1.3483453151328 0.09187264484642 no 354 0.0887736718121316 549 X1335 SGTC_724 3910-0327 137 µM 1.34745428563131 0.0920169500366237 no 355 0.0889169835288913 529 2885483 SGTC_566 0958-0068 16.5 µM 1.34696745529463 0.0920958646952333 no 356 0.088995357242682 454 6815365 SGTC_2468 5987765 72.9 µM 1.33981422905926 0.093261177767766 no 357 0.0901528742287627 523 26772094 SGTC_1336 1486-0901 104 µM 1.3378963433484 0.0935754596481615 no 358 0.0904651146636188 506 5006114 SGTC_1899 st063254 59.6 µM 1.33673863882775 0.0937655496098986 no 359 0.0906539823951503 449 3093813 SGTC_3275 9138069 49.47 µM 1.33654960911047 0.0937966145067714 no 360 0.0906848484474192 478 17617007 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.33354731474602 0.0942910266524594 no 361 0.091176129624653 605 551469 SGTC_487 nimodipine 119 µM 1.32960069905195 0.0949438683584429 no 362 0.091824933843248 398 4497 L-type voltage-gated calcium channels inhibitor SGTC_3147 9097027 49.47 µM 1.32686246270517 0.0953987749542706 no 363 0.0922770917465441 555 25236841 SGTC_176 1486-1328 72.834 µM 1.32502024520285 0.0957057263767343 no 364 0.092582218301922 563 22310231 SGTC_1734 st037168 69.4 µM 1.32236790829388 0.096148935695465 no 365 0.0930228348825908 524 708907 SGTC_891 0929-0073 133 µM 1.32219547395905 0.0961778018720829 no 366 0.0930515339184569 527 5603632 SGTC_1972 st070201 17.4 µM 1.31743110014838 0.0969778981788668 no 367 0.0938470809796291 545 2829099 SGTC_245 methotrexate 289.6 µM 1.31656456311437 0.0971239421188239 no 368 0.0939923118511432 579 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1552 6-methylflavone 10.6 µM 1.314821779615 0.097418155050742 no 369 0.0942849029669042 465 689013 SGTC_1409 3909-8004 61.9 µM 1.30934857318594 0.0983463796767565 no 370 0.0952081515513593 557 2119279 SGTC_2450 5739737 12.93 µM 1.30828441200934 0.0985276049883894 no 371 0.0953884301338524 512 2262825 SGTC_665 3914-0008 307 µM 1.30812067738611 0.0985555104779222 no 372 0.0954161905599487 537 1069549 SGTC_2669 eugenol 100 µM 1.30537885071116 0.0990236633016218 no 373 0.0958819381627304 470 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1389 3405-0187 19 µM 1.30385503468061 0.0992845492682986 no 374 0.096141506981556 499 799890 SGTC_2773 thioridazine 9.09 µM 1.29915137800781 0.100093011175631 no 375 0.0969459919718739 567 5452 An antipsychotic. SGTC_2265 7929201 200 µM 1.29852574847182 0.100200905171611 no 376 0.0970533671534878 541 1265108 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.29802977942619 0.100286498659762 no 377 0.0971385510505553 479 17037758 SGTC_970 1315-0089 19.5 µM 1.29743119879247 0.100389871732811 no 378 0.0972414317961912 520 6811083 YLR033W RSC58 SGTC_2372 9071633 200 µM 1.29540170933962 0.100740937169469 no 379 0.0975908443447934 596 21321366 SGTC_262 fenpropimorph 62.5 µM 1.28784301161372 0.102056333564243 no 380 0.0989003082405008 495 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2774 tamoxifen 10.92 µM 1.2765569252006 0.104043577471639 no 381 0.100879358735204 540 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_22 0964-0034 14.468 µM 1.27588617100279 0.104162560462264 no 382 0.100997880131807 589 138402 SGTC_556 4058-0063 51.5 µM 1.27541635060237 0.104245959156416 no 383 0.101080957215657 608 6615692 SGTC_3016 9080866 49.47 µM 1.2724472911117 0.104774122001156 no 384 0.101607120223373 597 17066299 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.26950314952152 0.105299763011209 no 385 0.10213083397362 622 6708784 An antioxidant flavonoid SGTC_1223 0764-0573 147 µM 1.26922318408424 0.105349846629183 no 386 0.102180737227141 602 1609797 SGTC_370 0180-0345 38.7 µM 1.26535475709823 0.106043642663913 no 387 0.102872092902576 504 3989527 SGTC_2070 5230947 200 µM 1.2650676549048 0.106095265262226 no 388 0.1029235382484 592 2835538 SGTC_1965 Pectolinarigenin 58.4 µM 1.26398945723343 0.106289293419941 no 389 0.103116905524313 574 5320438 An anti-inflammatory. SGTC_995 3931-2021 34.6 µM 1.26242417091532 0.106571431999941 no 390 0.103398098122446 546 730143 SGTC_3102 9121669 49.47 µM 1.26224407150874 0.106603929073089 no 391 0.103430487376668 514 41905072 SGTC_3225 9130819 49.47 µM 1.26035204583189 0.106945757869278 no 392 0.103771196287676 576 4547121 SGTC_1340 1486-1359 257 µM 1.25776412330097 0.107414592481248 no 393 0.104238537071409 592 4309068 SGTC_1171 0368-0077 21.4 µM 1.25477170297094 0.10795855166957 no 394 0.104780823843657 539 3239779 SGTC_1622 st003707 19.4 µM 1.25449149578205 0.108009588841079 no 395 0.104831707436646 617 10140899 SGTC_1168 k815-0004 80.5 µM 1.25398904065318 0.10810114994033 no 396 0.104922994445596 584 642433 SGTC_886 0866-0150 153 µM 1.25296524303591 0.108287886831782 no 397 0.10510917802367 605 271463 SGTC_3020 9089140 49.47 µM 1.25275002209181 0.108327171847753 no 398 0.105148347606272 567 17217859 SGTC_1801 st050089 28.441 µM 1.25272338549036 0.10833203463097 no 399 0.105153196124348 687 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1051 3253-3903 78 µM 1.25025726223303 0.108782931335162 no 400 0.105602792510258 602 5509239 SGTC_1534 6-azauridine 81.6 µM 1.24972482625018 0.108880456800099 no 401 0.105700042544875 638 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2783 7738165 71.43 µM 1.24835019647231 0.109132536180778 no 402 0.105951419563876 472 17201110 SGTC_2064 5220758 200 µM 1.24642467240591 0.109486343242428 no 403 0.106304264010553 642 788518 SGTC_2848 9016370 25.97 µM 1.24587437774916 0.109587608789459 no 404 0.10640525901237 658 7894410 SGTC_282 k297-0036 65.7 µM 1.2444184786528 0.109855848489373 no 405 0.106672792735451 533 5061378 SGTC_696 1560-0013 611 µM 1.23880415224064 0.110894662396691 no 406 0.107709017907297 597 1650269 SGTC_462 ag-879 158 µM 1.23824940952849 0.110997686696237 no 407 0.1078117979919 627 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2533 agelasine 13.65 µM 1.23642514115092 0.111336964893047 no 408 0.108150287829686 635 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2601 securinine 100 µM 1.23520396963474 0.111564493272612 no 409 0.108377301134672 577 442872 A GABA receptor antagonist. SGTC_965 1291-5240 308 µM 1.23280922390883 0.112011647247807 no 410 0.108823474588686 615 2834598 SGTC_1688 st021091 57.6 µM 1.23183452308788 0.112194012674799 no 411 0.109005452162917 582 3656366 SGTC_1448 4255-0083 152 µM 1.23149259393683 0.112258037486499 no 412 0.109069342457384 605 5399660 SGTC_1936 st074407 74.3 µM 1.22957221643999 0.112618105334531 no 413 0.109428669732959 631 809813 SGTC_1998 st075797 76.8 µM 1.2269197187815 0.113116799944459 no 414 0.109926383190592 658 24208315 SGTC_2852 9023854 51.95 µM 1.22378539261386 0.113708111544679 no 415 0.110516598098108 613 19798528 SGTC_355 1311-2252 105 µM 1.22356475006456 0.113749820095451 no 416 0.110558232012952 607 5338538 SGTC_671 0560-0003 407 µM 1.22301841173533 0.113853142568153 no 417 0.110661371133464 562 3238678 SGTC_32 0928-0142 34.1 µM 1.22188356654478 0.114067976054031 no 418 0.110875830397167 560 2244242 SGTC_2802 7925815 54.55 µM 1.22187603612609 0.114069402574468 no 419 0.110877254464341 616 1262923 SGTC_3092 9117248 49.47 µM 1.22152966725255 0.114135030494324 no 420 0.110942769970903 642 17141857 SGTC_2067 5224629 34.075 µM 1.22107790913901 0.114220667349485 no 421 0.111028261465193 598 2835000 SGTC_746 1095-0025 46.6 µM 1.2205846180704 0.11431422959 no 422 0.111121666606269 636 6749286 SGTC_1378 2093-0007 380 nM 1.22043292578997 0.114343011947609 no 423 0.111150400995429 609 3618014 SGTC_2710 st078562 53.7235 µM 1.21865652828284 0.114680452769485 no 424 0.111487292044089 592 17250908 SGTC_2646 retinol 96.75 µM 1.21855929297598 0.114698943822552 no 425 0.111505753640999 587 445354 A vitamin A analog and teratogen. SGTC_415 dibenzyl ketone 100 µM 1.21318723349725 0.115723836470333 no 426 0.112529121997 638 7593 SGTC_2733 amorolfine 100 µM 1.21183718489229 0.115982421144652 no 427 0.11278735555739 492 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2643 anethole 100 µM 1.20923955193965 0.116481118148592 no 428 0.113285413257232 642 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_14 0354-0009 295 µM 1.20819438111274 0.116682199903197 no 429 0.113486251286157 639 1713507 SGTC_1438 4092-1045 4 µM 1.20713539697238 0.116886190124601 no 430 0.113690002480832 621 1351342 SGTC_688 0527-0193 473 µM 1.20437681965877 0.117418756411049 no 431 0.114221983640235 578 4007154 SGTC_1540 guanosine 70.6 µM 1.20167971557757 0.11794111381069 no 432 0.114743821543694 580 6802 Guanosine is a purine nucleoside SGTC_2728 chlorpromazine 9.18 µM 1.19786890559838 0.118681965558962 no 433 0.11548402831883 518 2726 A thorazine and dopamine antagonist. SGTC_2856 9022925 19.48 µM 1.19752559390699 0.118748869166737 no 434 0.115550878958596 639 4944862 SGTC_3121 9125696 49.47 µM 1.19457862074137 0.119324263002656 no 435 0.116125853163014 588 1235365 SGTC_1074 carmofur 3.8 µM 1.19421561768414 0.119395274894291 no 436 0.116196817715124 686 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1367 1812-0510 76.9 µM 1.18871513560647 0.120474948534233 no 437 0.117275891280052 616 1142582 YDR527W RBA50 SGTC_2481 5478948 45.16 µM 1.18731494491437 0.120750882421292 no 438 0.117551707658113 607 77792 SGTC_2149 5554786 194.827 µM 1.18552917532156 0.121103446948455 no 439 0.117904143153717 664 745063 YPR165W RHO1 SGTC_1510 1123-0200 71.5 µM 1.18504381619312 0.121199396440607 no 440 0.118000061619918 714 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1866 st057638 64 µM 1.17765065337352 0.122667546405426 no 441 0.119467953612509 630 688802 SGTC_2730 imipramine 71.33 µM 1.17508019648056 0.123180904029242 no 442 0.119981316361042 742 3696 A tricyclic antidepressant. SGTC_849 0386-0493 241 µM 1.17433071509197 0.123330869462748 no 443 0.120131292544903 606 726119 SGTC_1465 k213-0056 144 µM 1.17373488159723 0.123450182375625 no 444 0.120250616991295 622 24048857 YMR208W ERG12 SGTC_574 1315-0397 40 µM 1.17047166823461 0.124105059766739 no 445 0.120905604570273 737 6794277 SGTC_1238 0333-0287 48.8 µM 1.16993655380921 0.124212680650901 no 446 0.121013251127675 644 7226 SGTC_139 0099-0334 718.624 µM 1.16826361618864 0.12454955873022 no 447 0.121350223322671 746 97690 SGTC_2581 avocatin a 64 µM 1.16596285014185 0.125013904578726 no 448 0.121814732960769 680 6710728 A skin care supplement. SGTC_419 nsc-638432 893 µM 1.16228853151038 0.125757969036437 no 449 0.122559141758038 647 368090 SGTC_372 0155-0182 15.9 µM 1.16152289656735 0.125913401348214 no 450 0.122714658674254 709 771486 SGTC_2120 5538279 151.968 µM 1.15939614375386 0.126345858301846 no 451 0.123147373962114 645 2058197 SGTC_1447 4239-0816 81.9 µM 1.15899309395692 0.126427931542579 no 452 0.123229500032215 618 1341554 SGTC_220 paclitaxel 373.376 µM 1.1589167543788 0.126443480793793 no 453 0.123245059428669 579 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1700 st030840 7.9285 µM 1.15884617756076 0.126457857440632 no 454 0.12325944549432 704 5499307 SGTC_1470 k295-0292 231 µM 1.15584908246553 0.127069423282888 no 455 0.123871446314361 691 5045612 SGTC_1952 st077036 64.1 µM 1.15559926090114 0.127120492861715 no 456 0.123922555242851 663 2937007 SGTC_1981 st071826 47 µM 1.15067273821277 0.128130512115984 no 457 0.12493344802754 620 11838600 SGTC_454 lyso-paf C-16 6.67 µM 1.15052972797855 0.128159914612005 no 458 0.124962878660341 621 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1959 st077091 55.8 µM 1.1504792569183 0.128170292436587 no 459 0.124973266452449 672 821356 YKL052C ASK1 SGTC_3189 9110682 49.47 µM 1.14789159728353 0.128703147410662 no 460 0.125506658719186 652 17122418 SGTC_75 0159-0059 199.013 µM 1.14661684579822 0.128966210583336 no 461 0.125770005543986 628 5377270 SGTC_538 2922-0838 53.3 µM 1.14483715294394 0.129334098955007 no 462 0.126138310914091 736 777039 SGTC_2996 9066192 71.4286 µM 1.14174558091216 0.129974899563011 no 463 0.126779894198305 645 6472854 SGTC_3353 9151644 39.2805 µM 1.14159545545463 0.130006072429787 no 464 0.126811106959038 679 4909158 SGTC_1345 1488-0192 31.4 µM 1.14128311652282 0.130070944767708 no 465 0.126876062858144 679 658348 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.14029787336528 0.130275725110804 no 466 0.12708111175531 721 165506 SGTC_739 1486-1183 203 µM 1.14021071928644 0.130293850601908 no 467 0.127099261365988 702 4346692 SGTC_3002 9075603 71.4286 µM 1.13896257326565 0.130553619763753 no 468 0.12735938243428 691 20105405 SGTC_1804 st050076 49.1 µM 1.13792779004553 0.130769254364002 no 469 0.127575317987575 682 3895976 SGTC_2628 lathosterol 100 µM 1.13695060064421 0.130973113103291 no 470 0.127779468598501 679 6710616 SGTC_1364 1653-0028 37.6 µM 1.13591670879969 0.131189039916906 no 471 0.127995712340025 690 5718652 SGTC_292 k038-0015 474 µM 1.13430650153697 0.131525818801609 no 472 0.128333001466358 627 46368540 SGTC_226 1,3-diallylurea 8.28947 mM 1.13341749019366 0.131712013232651 no 473 0.128519486308131 620 74537 YKL182W FAS1 SGTC_2568 diosmetin 100 µM 1.13026108538384 0.132374559150478 no 474 0.129183113435948 713 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3238 9133470 49.47 µM 1.13004650597851 0.132419683727507 no 475 0.129228314359729 671 3534688 SGTC_1459 k035-0031 35.7 µM 1.12805019649673 0.132840001986268 no 476 0.129649360286963 594 3877128 YMR208W ERG12 SGTC_2767 sibutramine 71.45 µM 1.12516781059769 0.133448500891227 no 477 0.130258965346374 707 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_516 3992-2719 87.3 µM 1.12479807865252 0.133526693313711 no 478 0.130337304413961 622 5350887 YDR037W KRS1 SGTC_1377 2944-0135 198 µM 1.12100980437133 0.134329668458746 no 479 0.131141844547482 692 1894137 SGTC_2664 lyso-paf C-16 73.48 µM 1.12077460145917 0.134379631945527 no 480 0.131191908958649 722 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2353 9059630 146.67 µM 1.12037620456695 0.134464291375823 no 481 0.131276740343321 660 4779114 SGTC_457 grayanotoxin iii 135 µM 1.12001618991565 0.134540826060306 no 482 0.131353431502492 733 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2087 5276107 200 µM 1.11918261272107 0.134718149071633 no 483 0.131531120777222 691 144405 SGTC_209 4077-0173 175.592 µM 1.11430350423804 0.135759275313851 no 484 0.132574502086177 575 15993494 SGTC_605 1315-0399 119 µM 1.11410962531838 0.13580075960449 no 485 0.132616079919457 730 24020461 SGTC_1863 st057641 20.1 µM 1.11266125788864 0.136110941588162 no 486 0.132926970247653 752 3921635 SGTC_1750 st081859 2.357 µM 1.10788320265274 0.137137645409934 no 487 0.133956130401272 852 5291695 SGTC_387 norethindrone acetate 66.7 µM 1.10720734370281 0.137283299314944 no 488 0.134102146605786 662 541197 SGTC_1478 0453-0656 35.7 µM 1.10717070604321 0.137291198089994 no 489 0.13411006512611 693 5258496 SGTC_37 0566-0070 1.56 µM 1.10657300427953 0.13742010146003 no 490 0.134239292148986 748 1626686 SGTC_2522 biochanin a 4.94 µM 1.1026833411033 0.138260984306412 no 491 0.135082351829963 664 5280373 A possible chelator. SGTC_1735 st034310 56.75 µM 1.10180703276784 0.138450911260066 no 492 0.135272786130829 697 871153 SGTC_2871 9038510 12.99 µM 1.10070181687549 0.138690703986663 no 493 0.135513227625871 752 4945164 SGTC_2090 5301565 104.445 µM 1.09923626291237 0.13900911338092 no 494 0.135832512626561 777 2056344 SGTC_572 0960-0087 17.7 µM 1.0989962072778 0.139061315778265 no 495 0.135884860113197 749 6796365 SGTC_834 0312-0008 75.7 µM 1.09811981417265 0.139252009132467 no 496 0.13607608714348 730 6385573 YIL048W NEO1 SGTC_2239 6685329 187.64 µM 1.09622573094655 0.139664748111779 no 497 0.136490000912851 702 805680 SGTC_2199 6590217 200 µM 1.09528275136715 0.139870542281485 no 498 0.136696390879905 638 703109 SGTC_1699 st031318 29.054 µM 1.09374675618546 0.140206196194245 no 499 0.137033030839445 720 5340658 SGTC_452 diindolylmethane 8 µM 1.09330303814678 0.140303261614941 no 500 0.137130384704211 651 3071 Inhibits expression of several cancer promoting factors. SGTC_3290 9121031 71.43 µM 1.09306619434578 0.140355090993904 no 501 0.137182368706399 649 17014854 SGTC_2662 daunorubicin 22.37 µM 1.09242256887995 0.140496003531409 no 502 0.137323703756085 674 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_777 1315-0167 517 µM 1.09175896881505 0.140641389748635 no 503 0.137469529154202 663 4221767 SGTC_2738 aclarubicin 5.55 µM 1.08921914737967 0.141198774917354 no 504 0.138028628613666 632 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2935 9038016 29.96 µM 1.08852326515481 0.141351753158323 no 505 0.138182085805485 761 6463195 SGTC_1708 st033234 31.827 µM 1.08657771473104 0.141780046276155 no 506 0.138611739134434 761 674664 SGTC_2806 7952793 58.44 µM 1.08476200016601 0.142180549438172 no 507 0.139013539893128 724 2972490 SGTC_604 1000-0114 314 µM 1.08031073543269 0.143165628495839 no 508 0.140001915366578 783 1572745 SGTC_2844 9010103 25.97 µM 1.08002742556107 0.143228481546998 no 509 0.140064983782076 704 2480525 SGTC_1169 aniline yellow 25.8 µM 1.073321871164 0.144721568237838 no 510 0.141563362716504 693 6051 A DNA damaging agent. SGTC_2202 7226349 200 µM 1.0713516991879 0.145162240328759 no 511 0.142005661005328 709 844334 SGTC_93 0109-0045 59.227 µM 1.07028448425715 0.14540132296882 no 512 0.142245638092009 851 88733 SGTC_2627 acetyl isogambogic acid 100 µM 1.06936399544905 0.1456077479467 no 513 0.142452842205285 678 6857789 A caspase activator and apoptosis inducer. SGTC_2444 5485484 36.41 µM 1.06273128820135 0.147100995040086 no 514 0.143951913805715 772 6790631 SGTC_2891 9063876 19.48 µM 1.06226433136984 0.147206508337348 no 515 0.144057851113757 674 6472478 SGTC_2376 9072922 81.32 µM 1.06150802345348 0.147377510844674 no 516 0.144229544274236 755 17087968 SGTC_129 0088-0017 176.636 µM 1.05947519406427 0.147837796550502 no 517 0.144691710282385 712 182446 SGTC_795 0685-0265 78 µM 1.05850646316135 0.148057480811198 no 518 0.144912302880174 762 302754 SGTC_1144 3486-0183 12.5 µM 1.05722312714306 0.148348846012983 no 519 0.145204883643747 782 6744069 SGTC_3168 9103419 49.47 µM 1.05718132858832 0.148358342290667 no 520 0.145214419747162 661 16649256 SGTC_305 1682-2595 20.8 µM 1.05422973675486 0.149029947118517 no 521 0.145888874324637 767 226033 SGTC_1791 st048313 56.1 µM 1.0499607594784 0.150004897379418 no 522 0.14686807725684 695 1204976 SGTC_219 mitoxanthrone 164.414 µM 1.04973098104878 0.150057494582321 no 523 0.146920907762708 719 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1011 4112-3381 17.4 µM 1.04962975824191 0.150080668789112 no 524 0.146944184887817 767 2877139 SGTC_371 0195-0006 7.36 µM 1.04835055173677 0.150373739179241 no 525 0.147238563444791 668 3928593 SGTC_199 4063-0024 41.6 µM 1.04750834456571 0.150566899628206 no 526 0.14743259279472 777 306215 SGTC_2210 7115885 190.385 µM 1.04629855634169 0.150844653967342 no 527 0.147711605873248 786 2927039 SGTC_3157 9099274 49.47 µM 1.04583308048577 0.150951613016219 no 528 0.147819052566494 736 17217662 SGTC_2401 5128683 200 µM 1.04226051826105 0.151774211897134 no 529 0.148645455925467 695 708373 SGTC_2147 5545932 89.7195 µM 1.04123085026639 0.152011849640525 no 530 0.148884210497537 735 797404 SGTC_3295 9122362 53.5725 µM 1.0408023145849 0.152110824459813 no 531 0.148983652810839 714 4730473 SGTC_2895 9054447 58.44 µM 1.04003514822058 0.152288116452121 no 532 0.149161785653848 735 2697450 SGTC_391 gliotoxin 8.33 µM 1.03493082531272 0.153471216066623 no 533 0.150350608824372 817 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1951 sophoraflavanone G 9.2 µM 1.0340263541235 0.153681491120944 no 534 0.150561921506954 779 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1292 0kpi-0043 232 µM 1.03390925817969 0.153708727990093 no 535 0.15058929322757 725 3333905 SGTC_914 3820-6779 408 µM 1.03135206562995 0.154304335602053 no 536 0.151187875343428 733 2893481 SGTC_470 aa-861 153 µM 1.03106066040962 0.154372304883853 no 537 0.151256187175865 793 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2338 7999974 200 µM 1.02922530541911 0.154800850134835 no 538 0.151686906815285 847 315925 SGTC_2729 fluphenazine 10.66 µM 1.02863759435077 0.15493824339174 no 539 0.151825002519019 792 3372 An atypical antipsychotic. SGTC_2471 5466956 24.79 µM 1.0285713502524 0.154953734779034 no 540 0.151840573270764 756 724419 SGTC_476 mead acid 10 µM 1.02812048107481 0.155059199104558 no 541 0.151946578776292 708 5312531 An omega 9 fatty acid. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.02511342801013 0.155763800950876 no 542 0.152654835145341 748 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1058 3448-5425 97.3 µM 1.02489284893998 0.155815569227771 no 543 0.152706874589646 742 7279705 SGTC_1523 st012844 44.7 µM 1.02380401298106 0.156071277164284 no 544 0.152963927281926 774 4274103 SGTC_2055 5235184 200 µM 1.02037782559482 0.156877704143426 no 545 0.153774653115889 761 2836034 SGTC_1280 0880-0253 10.1 µM 1.02005601295343 0.156953590279054 no 546 0.153850948291184 788 6836607 SGTC_3099 9120367 49.47 µM 1.0199242784471 0.156984661351862 no 547 0.153882187065809 779 24824940 SGTC_1600 coumarin 106 71.1 µM 1.01909945262395 0.157179297823569 no 548 0.154077877009458 816 100336 A hepatotoxic, DNA x-linker. SGTC_2507 purpurin 79.67 µM 1.01859267394555 0.157298962482071 no 549 0.154198191875899 782 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1888 azatryptophan 97.5 µM 1.01709057435176 0.157654002089869 no 550 0.154555171898755 711 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2570 licareol 100 µM 1.01527869200933 0.158082962623186 no 551 0.15498649929378 757 443158 SGTC_1268 0828-0275 2.46 µM 1.01260794978868 0.158716652648849 no 552 0.155623730559486 827 745337 SGTC_1248 0469-0687 58.6 µM 1.01092902023758 0.159115865503705 no 553 0.156025201612343 802 4017482 SGTC_1937 st074714 47.2 µM 1.0104947731427 0.159219226974657 no 554 0.156129151186017 764 17250970 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.00667051648899 0.160131392473605 no 555 0.157046567523131 855 16486 A toxic proline analog. SGTC_442 cape 100 µM 1.00633030238711 0.16021270584394 no 556 0.157128354257635 774 5281787 SGTC_2709 st078560 56 µM 1.00597914018268 0.160296664183765 no 557 0.157212802264606 812 17250903 SGTC_2173 5763948 167 µM 1.00229713894946 0.161178714126078 no 558 0.158100051976261 814 2867177 SGTC_1467 k284-1082 293 µM 1.00058545540635 0.161589836434929 no 559 0.15851363233131 839 3334705 SGTC_558 k064-0027 21.3 µM 1.00000893054835 0.161728463365168 no 560 0.158653093009853 824 5088526 SGTC_2140 5586273 200 µM 0.999989116959435 0.161733228972362 no 561 0.158657887322997 771 854421 SGTC_856 0433-0016 11.3 µM 0.997873799490057 0.162242536125314 no 562 0.159170279150897 818 3911780 SGTC_730 1436-0052 41.2 µM 0.993784669434902 0.163230037118976 no 563 0.160163855646249 773 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_7 0192-1582 4.227 µM 0.991003502076712 0.163903899518797 no 564 0.160841935108988 913 252616 SGTC_174 3553-0389 74.3 µM 0.990437920780582 0.164041157497592 no 565 0.160980059097255 737 738071 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.989908115781379 0.164169800735099 no 566 0.161109516148604 889 688801 SGTC_2795 7780010 54.55 µM 0.98838622063489 0.164539699607797 no 567 0.161481766661223 769 953673 SGTC_758 0868-0029 16 µM 0.986819809911988 0.164920981679847 no 568 0.16186549073012 829 762687 SGTC_1983 st071813 46.9 µM 0.985795155307489 0.165170703496726 no 569 0.162116821807673 805 11838595 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.984810146900287 0.16541099361885 no 570 0.162358667765323 865 4174840 SGTC_3196 9111891 49.47 µM 0.984633111063837 0.165454204994464 no 571 0.162402159690875 808 18891510 SGTC_2049 5262831 67.185 µM 0.982799232760735 0.165902252430992 no 572 0.162853129774305 810 763417 SGTC_2114 5491910 81.25 µM 0.982135603206428 0.166064581389942 no 573 0.163016523771702 812 2849228 SGTC_2125 5246583 200 µM 0.980592686424611 0.16644238737392 no 574 0.163396821175792 907 835267 SGTC_2990 9074105 71.4286 µM 0.979871959348864 0.166619058056808 no 575 0.163574662958253 788 6502001 SGTC_3243 9134147 49.47 µM 0.976888105984349 0.167351772502223 no 576 0.164312275389914 879 24282180 SGTC_3039 9090270 49.47 µM 0.975280946474674 0.167747285384826 no 577 0.164710459537492 789 17173750 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.974552399776842 0.167926774722311 no 578 0.164891167440265 760 2374 Ca(2+)-ATPase inhibitor. SGTC_1665 st014639 11.4 µM 0.97434538164852 0.16797779955445 no 579 0.164942539400982 865 981133 YIL048W NEO1 SGTC_3036 9090181 49.47 µM 0.973162866644549 0.168269451434612 no 580 0.165236181514616 814 25236586 SGTC_1254 0550-0035 264 µM 0.969786926727068 0.169103874078857 no 581 0.166076355302896 887 15121435 SGTC_1421 4029-0249 71.4 µM 0.969533456894673 0.169166630644846 no 582 0.166139547816243 923 2894095 SGTC_1995 st072814 61.1 µM 0.966388209057405 0.169946605990839 no 583 0.166924980946045 800 5769371 SGTC_3239 9133757 49.47 µM 0.964299747827681 0.170465785342822 no 584 0.167447833644003 855 17036923 SGTC_2453 5731132 22.18 µM 0.962149389422642 0.171001412122731 no 585 0.167987283845397 885 1362040 SGTC_1848 st056003 16.4 µM 0.961965359741848 0.171047301521399 no 586 0.168033502399617 899 146492 SGTC_904 1141-0088 396 µM 0.961402785780715 0.171187633063062 no 587 0.168174842062456 803 1378119 SGTC_1469 k284-2957 126 µM 0.960825994889349 0.171331587367252 no 588 0.16831983293961 837 23884841 SGTC_899 1083-0020 478 µM 0.959680643837418 0.171617671096707 no 589 0.16860798395694 858 767123 SGTC_290 2043-6722 48.1 µM 0.958698851406996 0.171863144236514 no 590 0.168855238634659 841 773758 YLR208W SEC13 SGTC_274 sirtinol 40.1 µM 0.957650571546619 0.172125488302272 no 591 0.169119494533053 841 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_123 0083-0120 66.675 µM 0.956507336306842 0.172411887243434 no 592 0.169407989849566 823 16001701 SGTC_2539 epi(13)torulosol 80 µM 0.954519939501451 0.17291048536929 no 593 0.169910260550747 808 6708597 SGTC_307 1501-1223 22.3 µM 0.953353222792065 0.173203618847832 no 594 0.170205566759249 832 2830329 SGTC_2465 5809242 33.21 µM 0.951173945192186 0.173752001774569 no 595 0.170758041219381 870 2731748 SGTC_237 nikkomycin 200 µM 0.950473986142511 0.173928370181568 no 596 0.170935732948651 885 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2804 7954240 19.48 µM 0.949547101024041 0.174162092174493 no 597 0.171171214147784 885 828705 SGTC_2956 9076196 2.52 µM 0.949442006798243 0.174188605174505 no 598 0.171197927108002 867 16423868 SGTC_3178 9107506 49.47 µM 0.94927537094476 0.174230649053813 no 599 0.171240288247478 845 8897194 SGTC_342 k048-0088 23.3 µM 0.948346299021496 0.17446518131868 no 600 0.171476594021452 837 6820570 SGTC_977 1348-1378 135 µM 0.946845875758249 0.174844367093456 no 601 0.171858660571259 908 X977 SGTC_2340 7987427 183.45 µM 0.946004513760676 0.175057224142828 no 602 0.172073141997466 813 2239331 SGTC_2649 anisomycin 9.56 µM 0.945521910522207 0.175179392600511 no 603 0.17219624510818 860 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1567 st069303 68.4 µM 0.944014188002796 0.175561412839584 no 604 0.172581199032143 861 5581319 SGTC_2146 5545642 200 µM 0.94382810360047 0.175608598679123 no 605 0.172628748388303 861 825326 SGTC_1265 0819-1001 68.8 µM 0.942341749878481 0.175985785144598 no 606 0.173008849803943 823 3106768 SGTC_3286 9117135 37.221 µM 0.941921872992727 0.176092428597407 no 607 0.173116320351097 813 3438150 SGTC_894 0960-0238 55.9 µM 0.941364822218583 0.176233975620708 no 608 0.173258967167591 895 6741907 YDL195W SEC31 SGTC_1822 st052468 42 µM 0.93978023151122 0.176637014928452 no 609 0.1736651504693 848 2873678 SGTC_308 4092-1169 104 µM 0.938203892837655 0.177038533152492 no 610 0.174069819105447 903 2268590 YDL196W YDL196W SGTC_2576 guaiol 23.12 µM 0.933173175059564 0.178323788870922 no 611 0.175365281240574 927 227829 SGTC_1501 4491-0275 38.4 µM 0.932797281468343 0.178420058253254 no 612 0.175462322558831 893 5104718 SGTC_1503 4585-0012 61.3 µM 0.93261647649577 0.178466375525757 no 613 0.175509011594568 863 2922052 SGTC_159 3970-0959 50 µM 0.930681428382286 0.178962555974548 no 614 0.176009189592488 1043 6615653 SGTC_1754 st042065 16.137 µM 0.928924189146355 0.179413894436185 no 615 0.17646418806339 947 1126236 YIL048W NEO1 SGTC_2198 6589944 200 µM 0.927931837957602 0.179669090962552 no 616 0.176721464011911 798 5290268 SGTC_3350 9150499 3.57 µM 0.927888676330038 0.179680195732189 no 617 0.176732659429982 924 4910996 YPR165W RHO1 SGTC_608 k048-0125 159 µM 0.927373895552479 0.179812673516423 no 618 0.176866219681642 898 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1466 k213-0079 57.5 µM 0.927157089471298 0.179868486477041 no 619 0.176922489265537 895 3657981 SGTC_2342 7990637 118.86 µM 0.92547363889033 0.180302231785345 no 620 0.177359794862091 884 2033102 YER133W GLC7 SGTC_2979 9012552 45.46 µM 0.924914007754502 0.180446567409394 no 621 0.177505319810733 842 17100905 SGTC_1629 st005085 44.9 µM 0.922285194928501 0.181125539499531 no 622 0.17818991721808 862 24207091 SGTC_1835 st008666 49.2 µM 0.920939235921236 0.181473793634473 no 623 0.17854107616884 779 690455 SGTC_803 4488-1585 147 µM 0.920008592019513 0.181714833855448 no 624 0.178784134646246 879 747204 SGTC_1834 st055981 52.8 µM 0.919967542876806 0.181725470346091 no 625 0.178794860342658 906 471719 YDL150W RPC53 SGTC_3352 9151559 45.5865 µM 0.914249434875719 0.183210928631868 no 626 0.180292896829369 862 17159339 SGTC_637 1181-0519 7.26 µM 0.914008718431031 0.183273627958149 no 627 0.180356132284625 953 6252091 YGR060W ERG25 SGTC_2965 9082772 38.63 µM 0.913670248143299 0.183361811824801 no 628 0.180445070905403 925 16459634 SGTC_2768 sulfasalazine 50.2 µM 0.912293278838351 0.183720835259391 no 629 0.180807175755355 913 5384001 An antioxidant and salicylic acid derivative. SGTC_2321 7390090 138.78 µM 0.91214437025572 0.183759687092169 no 630 0.180846361869497 799 649046 SGTC_910 3454-3003 490 µM 0.911382309698448 0.18395859690705 no 631 0.181046985625381 916 820824 SGTC_1763 st044482 94.5 µM 0.910735906488816 0.184127423383373 no 632 0.181217270128708 912 88505 SGTC_3148 9097893 49.47 µM 0.908718007117101 0.184655075067638 no 633 0.181749498253747 875 17174100 SGTC_1518 st038567 90.8 µM 0.908225979846732 0.184783875558773 no 634 0.181879420338939 895 77966 SGTC_1041 0206-0046 107 µM 0.907855716865431 0.184880838005686 no 635 0.181977228291483 891 50494 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.907802908340752 0.184894669789717 no 636 0.181991180768637 936 23847180 SGTC_2716 st080858 38.6235 µM 0.907662653015242 0.184931409052082 no 637 0.182028240707877 950 5296050 SGTC_2317 5986382 200 µM 0.907566653788595 0.184956558239965 no 638 0.182053609491395 934 877883 SGTC_2128 5255449 168.493 µM 0.90406927617576 0.185874224681823 no 639 0.182979334288982 950 736008 SGTC_860 0443-0016 25.1 µM 0.900121436594353 0.18691347252878 no 640 0.184027814625983 975 5337942 SGTC_2997 9067075 71.4286 µM 0.899802796345368 0.186997509406588 no 641 0.184112602986957 922 27209819 SGTC_2676 harmalol 100 µM 0.89894421667841 0.187224064025397 no 642 0.184341187175549 925 5459187 A monoamine oxidase inhibitor SGTC_1054 3429-0080 167 µM 0.898525705849395 0.187334558568275 no 643 0.184452673503652 944 1162877 SGTC_26 0302-0163 425.158 µM 0.896690820861931 0.187819477578741 no 644 0.184941960011593 937 3100915 SGTC_2341 7987486 176.74 µM 0.896458843048718 0.187880839269742 no 645 0.185003876095699 947 1258686 SGTC_386 1509-0011 3.07 µM 0.895648781786824 0.188095209974105 no 646 0.185220186648768 967 3107280 SGTC_27 0485-0001 32.618 µM 0.894030443858541 0.188523930956781 no 647 0.185652801312667 856 2054479 SGTC_2387 9077560 195.08 µM 0.893238937170841 0.188733831700669 no 648 0.185864615265877 888 5303272 SGTC_1228 0124-0032 52.5 µM 0.890330689891584 0.189506310011307 no 649 0.186644173339621 962 X1228 SGTC_979 1426-2828 121 µM 0.889750516747399 0.189660645988934 no 650 0.186799931088669 968 747872 SGTC_3130 9127414 49.47 µM 0.88928490106822 0.18978456362901 no 651 0.1869249920312 917 1494646 SGTC_104 0074-0074 590.992 µM 0.887113379875952 0.190363143453134 no 652 0.187508930595954 794 3943124 SGTC_2781 5567276 71.43 µM 0.885373424632297 0.190827517796609 no 653 0.187977630371268 884 2853274 SGTC_2939 9044578 71.43 µM 0.883173640644681 0.191415609093439 no 654 0.188571230571781 893 2653634 SGTC_122 0236-0016 402.397 µM 0.882718384694901 0.191537455996271 no 655 0.188694223200201 1001 6808838 SGTC_3272 9137413 49.47 µM 0.882021814666551 0.191723981312018 no 656 0.188882505286498 932 17614870 SGTC_1147 3809-1045 12.3 µM 0.881559284863458 0.1918478975077 no 657 0.189007590494862 902 325925 SGTC_1739 st037196 92.5 µM 0.880403586480439 0.192157734498697 no 658 0.189320357152632 979 612214 SGTC_1564 D-Arginine 115 µM 0.880302490182435 0.192184852466895 no 659 0.18934773198977 906 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2948 9070189 9.45 µM 0.879565963497209 0.1923824882874 no 660 0.189547242079002 842 6473636 YDL196W YDL196W SGTC_2189 6047310 154.431 µM 0.878848368462328 0.192575163566788 no 661 0.18974174831675 899 711535 SGTC_2630 antimycin a 100 µM 0.878540178728873 0.192657949138061 no 662 0.189825321714749 993 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_402 epigallocatechin gallate 10 µM 0.878272732024625 0.1927298079869 no 663 0.189897864956769 947 65064 An antioxidant. SGTC_679 0422-0091 41.4 µM 0.87460165078532 0.193717825952902 no 664 0.19089534463378 989 627384 YHR062C RPP1 SGTC_1015 4130-4525 82 µM 0.873332242916056 0.194060185834107 no 665 0.191241005508966 931 1363237 SGTC_1158 4092-0494 91.8 µM 0.873140628976566 0.194111896203334 no 666 0.191293215461896 976 1148199 SGTC_2034 5197015 53.07 µM 0.872383100962095 0.194316410546794 no 667 0.191499708220424 937 780676 SGTC_2496 diffractaic acid 79.83 µM 0.872330274405069 0.194330677338623 no 668 0.191514113177802 961 94870 An apoptosis inducer which activates caspases. SGTC_978 1416-0512 87.4 µM 0.871189883927222 0.194638816417484 no 669 0.191825241252496 962 6814003 SGTC_2897 9048598 12.99 µM 0.871187637623826 0.194639423672865 no 670 0.191825854407489 921 6467404 SGTC_2144 5628481 200 µM 0.868031854843965 0.195493681616908 no 671 0.19268844714268 928 2818399 SGTC_1762 st045503 25.4615 µM 0.867019589322324 0.195768179504325 no 672 0.192965638255313 960 4645554 SGTC_1545 lovastatin 49.4 µM 0.866994006416906 0.195775119896898 no 673 0.192972646837637 997 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1314 1222-0010 41.1 µM 0.866979732469942 0.195778992344313 no 674 0.192976557334089 949 3526027 SGTC_3022 9087993 49.47 µM 0.865902709315401 0.196071317189503 no 675 0.193271758616271 966 17173644 SGTC_1322 1348-1070 12 µM 0.865494473001812 0.196182189550828 no 676 0.193383724100402 953 6758089 SGTC_791 1348-1292 225 µM 0.86134131798501 0.197312298882794 no 677 0.19452504279458 1013 5437054 SGTC_2259 7964009 200 µM 0.860199174600826 0.197623774957102 no 678 0.194839629799131 899 313134 SGTC_760 0568-0725 82.9 µM 0.857642572269979 0.198322067172859 no 679 0.195544929840869 1003 3916171 SGTC_2555 cholic acid 100 µM 0.856829705718371 0.198544399387353 no 680 0.195769502996284 947 6708657 Influences liver metabolism. SGTC_2360 9040895 200 µM 0.852523722285516 0.199724661473101 no 681 0.196961739153295 905 4914414 SGTC_3267 9137951 49.47 µM 0.851347183634095 0.200047881286667 no 682 0.197288260884152 974 16643986 SGTC_620 0109-0052 432 µM 0.850456911733706 0.200292666498968 no 683 0.197535553232289 995 493037 SGTC_1443 4112-3303 14 µM 0.848316270719312 0.200881983804793 no 684 0.198130929283968 985 704433 SGTC_1868 st057644 42.7 µM 0.84597119228269 0.201528775424152 no 685 0.198784407553427 1035 688665 SGTC_33 0986-0033 35.816 µM 0.845490394542356 0.201661537306206 no 686 0.198918546725695 949 2848082 SGTC_1124 fisetin 1.16336 µM 0.845128648717454 0.201761460107617 no 687 0.199019507209983 925 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3141 9094609 49.47 µM 0.844572244324534 0.20191521009826 no 688 0.199174855663333 898 25236309 YDL196W YDL196W SGTC_3167 9103034 49.47 µM 0.84112474571049 0.202869412362348 no 689 0.200139026734179 951 5127859 SGTC_146 3448-8650 53.125 µM 0.839196881242537 0.203404181008776 no 690 0.200679418571446 1044 2891488 YIL048W NEO1 SGTC_1302 1159-0335 255 µM 0.838604380967793 0.203568702952397 no 691 0.20084567571789 955 649284 SGTC_2098 5376439 882.5 nM 0.838096773211312 0.203709715549755 no 692 0.200988177518426 1031 2844116 SGTC_999 SEC7.066 22.7 µM 0.837521427068044 0.203869616152153 no 693 0.201149768973313 1032 740511 YDR170C SEC7 SGTC_747 3448-8087 38.7 µM 0.836117512673645 0.204260106855684 no 694 0.201544398587612 984 5168703 SGTC_2075 5212009 200 µM 0.83562867566341 0.204396178521905 no 695 0.201681915742277 904 780898 SGTC_1790 st045711 43.5 µM 0.834951921587635 0.204584647431164 no 696 0.201872389507665 995 585119 SGTC_3081 9117243 49.47 µM 0.834277994391884 0.204772431802062 no 697 0.202062174627498 993 45595589 SGTC_1243 0416-0003 5.65 µM 0.832990994997872 0.205131328482344 no 698 0.202424903971414 973 2141977 SGTC_2868 9035608 32.47 µM 0.832478975473222 0.205274215727419 no 699 0.202569320320956 1013 6462614 SGTC_2992 9074591 71.4286 µM 0.83056783931432 0.20580807086084 no 700 0.203108904618156 960 17741321 SGTC_1907 st060210 83.7 µM 0.830302952247175 0.205882129134718 no 701 0.203183759667346 1060 688793 SGTC_2058 5236698 133 µM 0.828200051205951 0.206470628059002 no 702 0.203778607423787 973 766665 SGTC_3285 9112818 20.8695 µM 0.827044596105497 0.206794407095421 no 703 0.204105892526796 1048 17017947 YPR165W RHO1 SGTC_2792 7535235 81.82 µM 0.821624536001543 0.208317211301464 no 704 0.205645310246453 941 1281891 SGTC_1474 0330-0125 5.35 µM 0.821332631183601 0.208399411317767 no 705 0.205728412823865 1047 X1474 SGTC_1547 harmine 94.2 µM 0.821192394601709 0.208438908558486 no 706 0.205768343956095 1086 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_929 2805-0021 398 µM 0.820284436156661 0.208694739314749 no 707 0.206026988394684 983 3098024 SGTC_2061 5245884 80.95 µM 0.818005983186267 0.209337541580961 no 708 0.206676885420331 1027 573863 SGTC_680 0417-1641 114 µM 0.817312235289624 0.209533494456983 no 709 0.206875008189307 961 2835990 SGTC_578 3460-0051 92 µM 0.816617042703208 0.209729963587447 no 710 0.20707365625786 1110 2876744 SGTC_1279 0874-0590 65.2 µM 0.816460479460469 0.209774225034305 no 711 0.207118409045105 1007 3523074 SGTC_2872 9044037 25.97 µM 0.81529449788694 0.210104028309811 no 712 0.207451878733959 1030 6465195 SGTC_2292 7671323 168.05 µM 0.814809831476288 0.210241208017485 no 713 0.207590586218664 999 937504 SGTC_374 0880-0231 82.3 µM 0.814215493324595 0.210409500932821 no 714 0.207760755626845 1026 6833587 SGTC_189 3970-0742 2.116 µM 0.81095547429283 0.211334014158703 no 715 0.208695620543257 1038 2891807 SGTC_2122 5258151 111.688 µM 0.808501704436151 0.212031448970919 no 716 0.209400912629777 994 2173356 SGTC_231 b-estradiol 524 µM 0.808244322513242 0.212104682531471 no 717 0.209474973628781 978 450 A steroid. SGTC_2399 5884133 200 µM 0.807791649589591 0.212233518631476 no 718 0.209605266500089 1024 722445 SGTC_357 1325-0123 420 µM 0.806002671829838 0.212743130401024 no 719 0.210120654264553 1027 1098503 SGTC_353 1988-1175 58.3 µM 0.805949494083844 0.212758289645287 no 720 0.210135985660431 944 2788357 SGTC_2023 5144124 124 µM 0.805277562503677 0.212949889784259 no 721 0.210329763317037 1014 2830192 SGTC_47 0149-0135 24.25 µM 0.803779515871621 0.213377417508121 no 722 0.210762160963058 1035 5239155 SGTC_2499 avocadenofuran 51.48 µM 0.803253413827918 0.21352768047462 no 723 0.210914139195264 1023 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_286 k060-0067 22.9 µM 0.803153571230365 0.213556204041075 no 724 0.210942988574128 1001 5985051 SGTC_1417 3966-0327 90.4 µM 0.801297966189462 0.214086727150991 no 725 0.211479583999707 1080 651118 SGTC_2776 terbinafine 19.92 µM 0.801155561052538 0.21412747287682 no 726 0.211520797067082 1065 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1911 st060208 74.3 µM 0.799641911097322 0.214560845386407 no 727 0.21195914877143 1058 688783 SGTC_1232 0279-0259 161 µM 0.79951652167091 0.214596768436271 no 728 0.211995485255622 1026 1560000 SGTC_2817 7995342 71.43 µM 0.798813894054375 0.214798130199645 no 729 0.212199166448189 1008 18879975 SGTC_3349 9149703 23.001 µM 0.79687365747284 0.215354740525305 no 730 0.212762205651385 1067 4910494 SGTC_1719 st032227 49.2 µM 0.796696314647579 0.215405657909559 no 731 0.212813712410009 1079 3125804 SGTC_822 1487-0950 154 µM 0.796443145799237 0.215478358011427 no 732 0.212887254393649 1060 1958375 SGTC_2869 9037858 32.47 µM 0.795305366441602 0.215805258998277 no 733 0.213217946331632 1043 27187042 SGTC_323 4013-0906 34.3 µM 0.794680384527465 0.215984947870187 no 734 0.213399722727337 1077 2910086 SGTC_2417 cerulenin 830 nM 0.794261258615694 0.216105499516884 no 735 0.213521676358631 1051 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2944 9067346 25.62 µM 0.793569482231348 0.216304557835672 no 736 0.21372305227884 970 6473075 SGTC_2970 9090938 41.86 µM 0.792949875819365 0.216482939357171 no 737 0.213903513417941 1083 17217104 SGTC_41 0478-0632 82.643 µM 0.79247500904177 0.216619708677106 no 738 0.214041878989467 1100 3750424 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.792463762891138 0.216622948356332 no 739 0.214045156497891 1038 6708514 SGTC_2717 st081029 62.2815 µM 0.790106629780817 0.217302586126708 no 740 0.214732749176073 1042 5292846 SGTC_631 k072-0230 41.5 µM 0.78954891456782 0.21746357344065 no 741 0.214895626282508 1077 5773147 SGTC_2178 5812956 200 µM 0.788487826286346 0.217770051965823 no 742 0.215205708287807 1082 5403383 SGTC_1578 josamycin 24.2 µM 0.786207420080237 0.218429553611379 no 743 0.215872989864788 987 5282165 A P450 substrate. SGTC_2826 7992541 19.48 µM 0.785710722677766 0.21857335268889 no 744 0.216018489943043 1116 2985066 SGTC_1415 3966-0071 78.1 µM 0.785698679655017 0.218576839946198 no 745 0.216022018471779 1045 2893185 SGTC_92 0063-0024 660.874 µM 0.784749893181357 0.218851677486697 no 746 0.216300111762159 1146 3594437 SGTC_2289 7946404 165.07 µM 0.784636762429332 0.218884461639326 no 747 0.216333284682961 1116 1246120 YPR165W RHO1 SGTC_2335 9018011 154.17 µM 0.784624588892849 0.218887989575966 no 748 0.216336854460476 1092 6458208 SGTC_903 1134-0042 114 µM 0.781778758066071 0.219713619308596 no 749 0.217172303406355 1071 701009 SGTC_609 0986-0026 86.3 µM 0.780823749945287 0.219991085533785 no 750 0.217453081729142 1045 2848610 SGTC_2698 st077697 67.5 µM 0.779647815324331 0.220333015347983 no 751 0.217799101542856 1019 3154499 SGTC_754 3474-0146 171 µM 0.779493958188858 0.220377775347963 no 752 0.217844397625948 1031 24762078 SGTC_1839 st053978 48 µM 0.778386243379776 0.220700184702045 no 753 0.218170673103609 1108 3788398 SGTC_581 0958-0271 211 µM 0.777648407034081 0.220915087762086 no 754 0.218388157699578 1126 4591145 SGTC_2250 alverine citrate 130 µM 0.777385900611106 0.220991574565742 no 755 0.218465564183882 1052 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_767 0929-0023 86 µM 0.774444131064274 0.22184975744293 no 756 0.219334097402615 1168 1204563 SGTC_3000 9075062 71.4286 µM 0.772423897573252 0.22244020750712 no 757 0.219931702213748 1014 17057871 SGTC_2691 st077356 60.2 µM 0.772402506962677 0.22244646409432 no 758 0.219938034760317 1095 2839272 SGTC_1914 st062367 72.6 µM 0.770534478341666 0.222993234895395 no 759 0.220491455492959 1030 978205 SGTC_48 0382-0018 55 µM 0.769931032263604 0.223170026621304 no 760 0.220670402354667 1146 762596 SGTC_1616 st002734 56.1 µM 0.767244320907425 0.223958120838266 no 761 0.221468133010062 1074 4026101 SGTC_2099 5377090 177.372 µM 0.765032276485138 0.224608166022154 no 762 0.222126162587659 1054 2243829 SGTC_770 0389-1121 67.2 µM 0.763936047795652 0.224930706857827 no 763 0.222452677144731 1126 6753108 SGTC_1185 1319-0113 81.3 µM 0.762104544089222 0.225470171251774 no 764 0.222998805498522 1078 4672763 SGTC_1057 3448-5381 134 µM 0.762005686351574 0.225499310345088 no 765 0.223028305174826 1111 5497911 SGTC_2721 ifenprodil 61.44 µM 0.760421407712475 0.22596657959987 no 766 0.223501365470869 1088 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2304 7443016 91.4 µM 0.759369798269994 0.226277044726361 no 767 0.223815687444907 1022 939854 SGTC_2749 bexarotene 57.39 µM 0.758730845749913 0.226465799376575 no 768 0.224006790514153 1070 82146 An retinoic acid receptor inhibitor. SGTC_2971 9092186 9.93 µM 0.755578497532338 0.227398343137635 no 769 0.224950975976984 1050 25236400 SGTC_2942 9052777 62.25 µM 0.754248732238168 0.227792368897367 no 770 0.225349940256249 1161 6469503 SGTC_3089 9117425 49.47 µM 0.75342546795923 0.228036504648802 no 771 0.225597141691985 1074 9401657 SGTC_132 0417-1715 25.805 µM 0.752075804083335 0.228437060315642 no 772 0.226002736857758 1126 6769098 SGTC_3210 9128157 49.47 µM 0.751999274329862 0.228459784790568 no 773 0.226025747592525 1017 17590849 SGTC_2047 4141938 200 µM 0.751444769538435 0.228624475421164 no 774 0.226192513972354 1070 3807862 SGTC_1548 st061468 90.8 µM 0.751140807884756 0.228714781800433 no 775 0.226283959419842 1129 390799 SGTC_3120 9124077 49.47 µM 0.749492616603809 0.229204804606138 no 776 0.226780173578617 1187 18774327 YGL155W CDC43 SGTC_364 0083-0097 67.7 µM 0.748532572999781 0.229490505745525 no 777 0.227069492675553 1115 5207356 SGTC_599 1935-0052 86.5 µM 0.747898522791048 0.229679303279587 no 778 0.227260684329977 1133 9557311 SGTC_145 3737-0113 38.366 µM 0.745248085202729 0.230469450217009 no 779 0.228060879388525 1196 6849351 SGTC_2267 7931562 200 µM 0.744815519522537 0.23059855052372 no 780 0.22819162577251 1062 934880 SGTC_263 alizarin 107.927 µM 0.744729570372708 0.230624207073498 no 781 0.228217609597668 1143 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2185 6113692 200 µM 0.744119538409975 0.230806352613332 no 782 0.228402079967785 1111 874150 SGTC_2416 tofa 880 nM 0.740050660637549 0.232023305734385 no 783 0.229634627558353 1060 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1006 4099-6547 255 µM 0.739517822435459 0.232182935450245 no 784 0.229796310766699 1116 3146833 SGTC_1204 4049-0315 18.3 µM 0.738816917786603 0.23239300820459 no 785 0.230009088712336 1080 588402 SGTC_1973 st070275 50.2 µM 0.738457194013378 0.232500864428638 no 786 0.230118335076614 1100 17118334 SGTC_2156 5649887 115 µM 0.737747495708477 0.23271373536352 no 787 0.230333952118207 1188 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_478 N-arachidonylglycine 10 µM 0.735168229991438 0.233488286407942 no 788 0.2311185224969 1059 5283389 SGTC_472 calcifediol 10 µM 0.734520072611172 0.233683152026066 no 789 0.231315915569474 1085 5283731 A vitamin D metabolite. SGTC_1065 prochlorperazine maleate 2.48 µM 0.733548619010141 0.233975383966366 no 790 0.231611942889008 1197 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_475 α-linolenic acid 10 µM 0.733453625771685 0.234003970622732 no 791 0.231640901141781 1230 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2115 tiliquinol 12.7705 µM 0.733360017075264 0.234032142516369 no 792 0.231669439297054 1106 71208 A bioactive hydroxyquinoline. SGTC_3007 9078383 71.4286 µM 0.732594981582274 0.234262453261485 no 793 0.231902746412355 1138 6496995 SGTC_3310 9130229 44.1445 µM 0.731277513715369 0.234659365371782 no 794 0.23230483120308 1116 7761258 SGTC_2176 5809774 33.9695 µM 0.731215573717591 0.234678035115821 no 795 0.232323744530944 1143 2870539 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.72987701660522 0.235081699065763 no 796 0.232732681084521 1133 616764 SGTC_2534 helenine 20.12 µM 0.727257156518251 0.235872869815321 no 797 0.233534219200089 1144 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2855 9016525 58.44 µM 0.725959277273561 0.236265358994836 no 798 0.233931867737909 1191 43811474 SGTC_954 1189-0853 2.85 µM 0.725845321024557 0.236299837452755 no 799 0.233966799936047 1156 2828194 SGTC_322 k048-0136 19.3 µM 0.723597867960397 0.236980389811801 no 800 0.234656325349712 1172 6823282 SGTC_717 1532-0246 73.2 µM 0.723585105751055 0.236984257416329 no 801 0.234660244040267 1141 9561992 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.722840532184171 0.237209961473676 no 802 0.234888931147678 1163 2724 A muscle relaxant with antifungal properties. SGTC_126 0417-1624 672.48 µM 0.721727943197465 0.237547442709417 no 803 0.235230879319435 1267 41912 YDL195W SEC31 SGTC_2380 9035439 200 µM 0.71972822009336 0.238154679929613 no 804 0.235846173751705 1230 6462575 SGTC_438 sphingosine 6.67 µM 0.719136664639314 0.238334474930356 no 805 0.236028359246603 1079 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2518 prenyletin 46.28 µM 0.718777038321901 0.238443814640669 no 806 0.236139153784064 1084 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.718634779434018 0.238487074187464 no 807 0.236182989149711 1224 23665772 A membrane-active detergent. SGTC_1608 st001473 40.5 µM 0.718152538397213 0.238633750970433 no 808 0.236331619269621 1129 7292267 SGTC_2842 9000675 19.48 µM 0.717239396287952 0.238911624343295 no 809 0.236613197191432 1139 2989072 SGTC_2306 7482397 179.52 µM 0.715128972847473 0.239554512471724 no 810 0.23726467632797 1151 891448 SGTC_1093 fluphenazine 7.97 µM 0.715062870036934 0.239574664295013 no 811 0.237285097896919 1228 6602611 An atypical antipsychotic. SGTC_1162 k048-0130 20.1 µM 0.714988105760373 0.239597457731401 no 812 0.237308196471919 1142 6797406 SGTC_2003 4023581 200 µM 0.713312227558957 0.240108694401012 no 813 0.237826286375067 1172 16641307 SGTC_1957 st077035 62.4 µM 0.712495772685932 0.240357974094039 no 814 0.238078914119297 1220 705593 SGTC_542 3381-0244 89.3 µM 0.712489608561074 0.240359856658382 no 815 0.23808082198412 1187 1112843 SGTC_540 1187-0821 17.3 µM 0.711208529621443 0.240751280858195 no 816 0.238477511860625 1164 847520 SGTC_1817 st052116 64.4 µM 0.709425616174924 0.241296613708922 no 817 0.239030198011937 1173 4361398 SGTC_377 3970-0964 33.1 µM 0.707388809288729 0.241920424481945 no 818 0.239662444670059 1189 16481235 SGTC_427 1354-0053 47.3 µM 0.70506349260652 0.242633665056214 no 819 0.240385362223634 1202 6813657 SGTC_832 4083-0019 164 µM 0.703348150124907 0.243160538103125 no 820 0.240919405310632 1272 1990758 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.70309778649073 0.243237489810182 no 821 0.240997405760301 1119 1241132 A phosphatase inhibitor. SGTC_2083 5306046 65.942 µM 0.702120015276571 0.243538143394586 no 822 0.241302160561608 1198 539837 SGTC_1933 st074711 15.9 µM 0.70193386694451 0.243595404636389 no 823 0.241360203577741 1199 17250958 SGTC_2885 9057732 51.95 µM 0.701683128411541 0.243672546014528 no 824 0.24143839848936 1211 6471414 SGTC_1920 st075728 45.7 µM 0.701055995247281 0.243865545443579 no 825 0.241634035455583 1179 3400306 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.700167889438486 0.244138999938374 no 826 0.241911231166171 1232 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_115 0527-0192 112.043 µM 0.699629618476897 0.244304818083311 no 827 0.242079320301678 1221 4233931 SGTC_2270 7924575 90.91 µM 0.696098169201033 0.24539420981649 no 828 0.243183676500297 1178 1262135 SGTC_2030 5175110 200 µM 0.695980368371076 0.245430594299149 no 829 0.243220562108424 1226 2831986 SGTC_1105 epirubicin 18.1 µM 0.689985677116259 0.247285962416694 no 830 0.245101597264631 1173 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2179 6298986 200 µM 0.689980119363519 0.247287686023969 no 831 0.245103344818656 1155 738374 SGTC_2929 9013348 24.6 µM 0.689648643943536 0.247390497001937 no 832 0.245207584531999 1199 2995952 SGTC_722 3534-0461 190 µM 0.689648366221662 0.247390583150202 no 833 0.245207671877724 1183 658262 SGTC_831 k061-1017 217 µM 0.687541239296278 0.248044667189425 no 834 0.245870861277453 1255 1240153 SGTC_937 3122-0005 46.7 µM 0.687206270109239 0.248148731615452 no 835 0.245976376863137 1203 759535 SGTC_1312 1218-2183 165 µM 0.685814566139192 0.24858133965026 no 836 0.246415024876732 1230 6744073 SGTC_909 3448-9333 149 µM 0.684535502771115 0.248979287643316 no 837 0.246818539352299 1172 3344074 SGTC_389 tpck 16.7 µM 0.68406035325487 0.249127204627423 no 838 0.246968527932649 1198 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2139 5578692 56.4705 µM 0.683696111476672 0.249240626989414 no 839 0.247083539719614 1169 650991 YMR113W FOL3 SGTC_131 0141-0277 33.849 µM 0.683125775632339 0.249418280758601 no 840 0.2472636846307 1165 1547771 SGTC_945 3381-0768 11.3 µM 0.681402493307017 0.249955474174012 no 841 0.247808422827281 1232 1126236 YIL048W NEO1 SGTC_1615 st002656 86.5 µM 0.681044296782484 0.250067210685601 no 842 0.247921730920125 1220 1584458 SGTC_1368 1852-0141 284 µM 0.680487481596073 0.250240957284517 no 843 0.248097922820664 1206 2838987 SGTC_1747 st037496 66.6 µM 0.679290835527865 0.250614570906871 no 844 0.248476801020215 1254 723305 SGTC_782 0083-0095 30.5 µM 0.678975475572942 0.250713080918735 no 845 0.248576700576449 1241 3591729 An indicator and reagent. SGTC_1126 isoteolin 1.0172 µM 0.677540877033569 0.251161469811953 no 846 0.249031421860704 1211 133323 SGTC_1826 st055655 41.6 µM 0.676290060463625 0.251552762843265 no 847 0.249428251087339 1241 676168 SGTC_29 0299-0004 12.984 µM 0.675828221215619 0.251697321418057 no 848 0.249574857328829 1129 16871 A napthoquinone isolated from Swertia calycina. SGTC_837 0091-0265 12.5 µM 0.675071521888797 0.251934267838094 no 849 0.249815162863162 1194 759367 SGTC_375 3970-0961 9.27 µM 0.674469355573489 0.252122909181477 no 850 0.250006480977844 1193 2898222 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.674210015129113 0.252204176012954 no 851 0.250088901636329 1211 61125 An anti-inflammatory. SGTC_2977 9011197 71.43 µM 0.672208855795963 0.252831722873202 no 852 0.250725372003958 1247 2704722 SGTC_507 nimesulide 162 µM 0.671832102867926 0.252949961326357 no 853 0.250845294457155 1270 4495 A COX2 inhibitor. SGTC_1013 4112-3890 241 µM 0.671701666466606 0.252990903683079 no 854 0.250886820129825 1196 705171 SGTC_2184 6075246 200 µM 0.671601080227409 0.253022478828035 no 855 0.250918845203358 1258 2267320 SGTC_2094 5332512 191.667 µM 0.671141546237618 0.253166758054994 no 856 0.251065181101608 1277 755774 SGTC_385 1494-0393 12.4 µM 0.671083421020353 0.253185010628136 no 857 0.25108369395161 1248 3090647 SGTC_1626 st003712 1.76 µM 0.67103642256479 0.253199769663888 no 858 0.251098663462096 1211 24207035 SGTC_2589 lobaric acid 100 µM 0.669624529101231 0.253643360767634 no 859 0.251548586666856 1224 73157 A novel microtubule depolymerizer. SGTC_1198 1612-1005 86.7 µM 0.666925194572021 0.254492577118756 no 860 0.252409958440644 1300 6998509 SGTC_2029 5175081 200 µM 0.666677666301478 0.254570524535785 no 861 0.252489023748405 1246 1380876 SGTC_225 nsc-122657 1.016 µM 0.666227128845417 0.254712432263598 no 862 0.252632967596519 1204 275685 SGTC_2591 skatole 100 µM 0.665505766698575 0.254939729037815 no 863 0.252863528185516 1252 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1787 fluconazole 80 µM 0.663265771131139 0.255646213797936 no 864 0.253580177264406 1170 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2653 dihydrofissinolide 100 µM 0.662736803204787 0.255813197061455 no 865 0.253749567291097 1268 6857746 SGTC_2337 9009472 200 µM 0.66239987043087 0.2559195888251 no 866 0.253857493364822 1287 5742383 SGTC_1427 4048-4900 550 nM 0.662170988992194 0.255991874866815 no 867 0.253930822250413 1243 24132586 SGTC_2449 5812982 45.77 µM 0.660236253805697 0.256603334220943 no 868 0.254551115287048 1224 776185 SGTC_1488 4013-0813 75.9 µM 0.659284704400061 0.256904343476397 no 869 0.254856481303156 1239 2910057 SGTC_3324 9138759 60.749 µM 0.658858855173793 0.257039114371075 no 870 0.254993204580775 1258 45595710 SGTC_1614 st002383 48.6 µM 0.658038113328623 0.257298962847791 no 871 0.255256820414534 1257 1947235 SGTC_312 4092-0653 6.84 µM 0.656953505836077 0.257642561019234 no 872 0.255605406254193 1266 1148278 SGTC_3220 9131269 49.47 µM 0.656319382852921 0.257843558284467 no 873 0.255809324399048 1293 17722206 SGTC_1352 1496-0991 99 µM 0.655281639862598 0.258172665998565 no 874 0.256143219781626 1252 3000039 SGTC_3191 9110352 49.47 µM 0.65501554054609 0.258257091265572 no 875 0.256228874236582 1262 17122424 SGTC_1307 1187-1599 12.2 µM 0.654812002777842 0.258321677302289 no 876 0.256294400892647 1253 1538471 SGTC_2914 7968218 45.32 µM 0.653267610696868 0.258812012055259 no 877 0.256791884702137 1226 2977111 SGTC_188 3229-0966 278.469 µM 0.652753129968354 0.258975463325706 no 878 0.256957722184424 1362 5722370 SGTC_449 xestospongin c 11.1929 µM 0.652730396644055 0.258982686967206 no 879 0.256965051318984 1239 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2955 9076254 12.21 µM 0.651719868689153 0.259303893145669 no 880 0.257290951399008 1192 16459619 SGTC_2397 5161689 200 µM 0.650798910303403 0.259596807954751 no 881 0.257588151871219 1332 2259942 SGTC_2624 nerol 100 µM 0.649465347456236 0.260021255979926 no 882 0.258018818799661 1227 637566 A natural product oil. SGTC_423 5-fluorouracil 457 µM 0.647889041922106 0.260523425538329 no 883 0.258528359368263 1237 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2362 9071156 126 µM 0.646228489906234 0.261052973394309 no 884 0.259065695715018 1293 653133 SGTC_168 3970-0862 530.542 µM 0.645642559871579 0.261239957699049 no 885 0.259255433965813 1279 3135186 SGTC_1260 0700-1617 7.75 µM 0.642751863571667 0.262163454268668 no 886 0.260192561072289 1303 2853078 SGTC_1210 3013-0140 750 nM 0.641309782598108 0.262624783397366 no 887 0.260660717317217 1308 905973 SGTC_2695 st077686 51.995 µM 0.640506266821331 0.26288201232618 no 888 0.260921758118779 1261 2876092 SGTC_753 1322-0200 289 µM 0.639955242180324 0.263058485881684 no 889 0.261100848979437 1302 5403907 SGTC_2834 9001755 58.44 µM 0.639618876028112 0.263166241724083 no 890 0.261210203821753 1259 2989575 SGTC_2238 6671620 73.2395 µM 0.639438340502573 0.263224086085447 no 891 0.26126890680934 1247 729941 SGTC_3279 9140807 49.47 µM 0.638736274113813 0.263449092903544 no 892 0.26149725534614 1309 45595718 SGTC_1788 fluconazole 20 µM 0.638030586882481 0.263675359072741 no 893 0.261726884785528 1260 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2019 4016004 108 µM 0.637962434459675 0.263697216193482 no 894 0.261749066946398 1249 45595336 SGTC_1178 0988-0033 191 µM 0.637560200628757 0.263826235173354 no 895 0.261880005126236 1294 5392207 SGTC_613 3914-0030 117 µM 0.636116674311462 0.264289520007529 no 896 0.262350189098276 1101 1145395 SGTC_53 0973-0023 39.979 µM 0.636023512278319 0.264319433621304 no 897 0.262380548588271 1270 674768 SGTC_2118 5526350 200 µM 0.634380594611004 0.264847244965986 no 898 0.262916235344892 1309 743594 SGTC_204 PMA1.184 62.41 µM 0.633324304912135 0.265186876225921 no 899 0.263260942330005 1308 2252213 YGL008C PMA1 SGTC_3335 9143315 29.6265 µM 0.630359307453883 0.266141398935831 no 900 0.264229764103693 1280 4899691 SGTC_961 1252-1571 372 µM 0.630323966816223 0.266152786642756 no 901 0.264241322702984 1335 6813498 SGTC_991 3996-0057 64.7 µM 0.627431577563551 0.267085628086598 no 902 0.265188187014511 1304 715343 SGTC_653 0203-0016 55.2 µM 0.622667093620191 0.268625840624248 no 903 0.266751655567126 1333 295302 SGTC_201 4262-0159 12.803 µM 0.621708718571253 0.268936192431469 no 904 0.267066708838827 1281 1341029 SGTC_1729 st035615 45.989 µM 0.620357080482609 0.269374200866213 no 905 0.267511361314598 1305 17385451 SGTC_1865 st057639 52.2 µM 0.618864212697242 0.269858391164127 no 906 0.268002908024348 1311 688818 SGTC_1313 1220-0047 237 µM 0.618852749160739 0.269862110883142 no 907 0.268006684305926 1361 3528706 SGTC_2777 climbazole 1.536 µM 0.618606838052306 0.26994191095868 no 908 0.268087698008609 1300 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_480 am 92016 50 µM 0.618531490687828 0.269966364130574 no 909 0.268112523140146 1241 2129 K+ channel blocker. SGTC_2129 girgensonine 121.053 µM 0.618233719429867 0.270063013416912 no 910 0.268210642877482 1372 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1519 esterone 74 µM 0.617181760703998 0.27040459210368 no 911 0.268557422391177 1269 698 A steroid. SGTC_2561 acetosyringone 100 µM 0.614591090765988 0.271246721176861 no 912 0.269412399788827 1302 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1773 st048542 73.5835 µM 0.61427189839988 0.271350568965255 no 913 0.269517834549878 1260 3237138 SGTC_779 1360-0071 233 µM 0.613934786936139 0.271460268158806 no 914 0.269629210747045 1425 7566 SGTC_190 3970-0790 3.722 µM 0.613248158987465 0.271683771557061 no 915 0.269856132848412 1343 2832352 SGTC_1350 1495-0454 146 µM 0.610042909431074 0.272728318679609 no 916 0.270916691735519 1369 1069057 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.60962916684838 0.272863296816104 no 917 0.271053743057012 1335 1609 A potent and irreversible inhibitor of serine proteases. SGTC_9 0092-0002 10.449 µM 0.607577565100594 0.273533094291397 no 918 0.27173384209745 1321 759368 SGTC_1363 1636-0063 10.4 µM 0.606894116121815 0.273756404119115 no 919 0.271960591573394 1347 6072185 SGTC_2502 avocadyne acetate 18.59 µM 0.606620211317348 0.273845924960591 no 920 0.272051492023608 1291 3952079 SGTC_2143 5623677 140.463 µM 0.604990726950487 0.274378791519888 no 921 0.272592579071618 1299 5375313 SGTC_3347 9188721 44.724 µM 0.604648260445812 0.274490848411383 no 922 0.27270636649609 1322 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_976 1348-1067 47.6 µM 0.603920995770953 0.274728888216062 no 923 0.272948084548115 1365 5310671 YGL099W LSG1 SGTC_1125 tnp00248 1.32998 µM 0.602595997165795 0.275162832808733 no 924 0.273388741946535 1431 24207736 SGTC_2563 tomatine 8.54 µM 0.599794266559572 0.276081525428542 no 925 0.274321677424996 1373 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2390 9097792 176.6 µM 0.599176726749835 0.276284220223177 no 926 0.274527520387863 1300 4497149 SGTC_1480 1070-0044 41.2 µM 0.599001719639824 0.276341675997902 no 927 0.274585868915146 1366 3124987 SGTC_3298 9116858 71.43 µM 0.59687899944535 0.277039042782325 no 928 0.275294084584595 1410 2506942 SGTC_2830 7992007 71.43 µM 0.596516450864226 0.277158235144094 no 929 0.275415133637321 1351 1952075 SGTC_13 0199-0087 65 µM 0.594023083683222 0.277978639627611 no 930 0.276248336886576 1367 4589825 SGTC_2805 7950783 58.44 µM 0.5926371217613 0.278435181150803 no 931 0.276712015104386 1380 1178958 YDL195W SEC31 SGTC_3050 9093513 49.47 µM 0.592559340845258 0.278460813325943 no 932 0.27673804826779 1343 25236664 SGTC_1630 st005209 31.3 µM 0.592163700493461 0.278591211723915 no 933 0.276870487110316 1359 3367314 SGTC_2255 7941087 197.44 µM 0.590262286379358 0.279218309985663 no 934 0.277507409700624 1411 935561 SGTC_1334 1486-0610 236 µM 0.589539398618606 0.279456902758394 no 935 0.277749745392076 1367 3742339 SGTC_1766 st045414 44.774 µM 0.589056247352802 0.279616424469915 no 936 0.277911771143612 1360 253960 SGTC_490 phenamil 164 µM 0.588710884349938 0.27973047981169 no 937 0.278027617590744 1372 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2027 5150920 200 µM 0.586778775280265 0.280368970486815 no 938 0.278676146667672 1346 786715 SGTC_959 1222-0044 107 µM 0.585874779175512 0.280667949943229 no 939 0.27897983348101 1361 6083612 SGTC_2607 solasodine 47.35 µM 0.585837905800115 0.280680148381351 no 940 0.278992224072037 1365 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1611 st001856 99.4 µM 0.58378842991243 0.281358558283855 no 941 0.279681331726275 1314 647478 SGTC_576 1073-0113 22.7 µM 0.582830179814067 0.281676025972367 no 942 0.280003813099102 1472 5439563 SGTC_2440 5628896 157.78 µM 0.580435250696078 0.282470218953158 no 943 0.280810569620553 1399 5522048 SGTC_195 4234-0266 16.654 µM 0.580244526656428 0.282533512054398 no 944 0.28087486526155 1356 2303354 SGTC_627 1391-0720 175 µM 0.577455322608597 0.28345990699243 no 945 0.281815955640136 1350 997839 SGTC_881 0833-0569 170 µM 0.575173160460557 0.284218976446869 no 946 0.282587096344229 1327 5418700 SGTC_3248 9135562 49.47 µM 0.57514363886062 0.28422880198356 no 947 0.282597078310291 1398 17650701 SGTC_175 3793-3120 23.7 µM 0.573779928186866 0.284682856378438 no 948 0.283058366479868 1365 5322297 SGTC_745 0469-0705 296 µM 0.57289353331544 0.284978171608586 no 949 0.28335839167999 1475 3486736 SGTC_3035 9091303 49.47 µM 0.572300297430771 0.285175898268626 no 950 0.283559274136798 1397 25237002 SGTC_743 1275-0778 158 µM 0.571982612424456 0.28528181016581 no 951 0.283666877175433 1429 2849257 YMR203W TOM40 SGTC_1670 st016595 4.04 µM 0.571241203541702 0.285529058763268 no 952 0.283918075718931 1371 597879 SGTC_2411 st077133 39.94 µM 0.567961118815777 0.286624139294322 no 953 0.285030684683209 1532 1403142 YNL221C POP1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.566679866497866 0.287052435178511 no 954 0.28546585104623 1402 2724278 An inhibitor of dopamine biosynthesis. SGTC_1647 st011722 22.4 µM 0.566416705901966 0.287140441772734 no 955 0.285555270428371 1385 2854783 SGTC_661 1304-0007 33.6 µM 0.564283352674721 0.28785435231775 no 956 0.286280654534322 1379 3117130 SGTC_2763 lisinopril 49.32 µM 0.564253597738807 0.287864315507184 no 957 0.286290778009906 1369 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2552 juarezic acid 87.02 µM 0.563004566491313 0.288282689920999 no 958 0.286715887210783 1414 1549512 SGTC_1807 st050092 58.9 µM 0.562105922756931 0.288583876104374 no 959 0.287021926627693 1368 5008496 SGTC_1234 0326-0494 15.5 µM 0.561678386775462 0.288727219539646 no 960 0.287167581293432 1467 1547813 SGTC_1871 st057448 67.3 µM 0.5614241151327 0.288812487139535 no 961 0.287254224162457 1472 691747 SGTC_2062 5245942 200 µM 0.56126869911693 0.288864610272538 no 962 0.287307188142778 1440 1376160 SGTC_3172 9105863 49.47 µM 0.560953805720369 0.288970232202456 no 963 0.287414514332911 1394 2348785 SGTC_1475 4092-1048 11.7 µM 0.560300102204489 0.289189556233361 no 964 0.287637378857293 1384 2881759 SGTC_136 0097-0015 404.482 µM 0.55989835785785 0.289324384272895 no 965 0.287774384460062 1395 4861337 SGTC_3125 9127534 49.47 µM 0.559012849169185 0.289621671064828 no 966 0.288076475499648 1319 1639235 SGTC_3109 9122853 49.47 µM 0.55872661970073 0.289717795913139 no 967 0.288174154598162 1476 1234709 SGTC_2857 9024691 58.44 µM 0.558695709455778 0.289728177440187 no 968 0.288184704009541 1416 16478292 SGTC_774 k060-0086 136 µM 0.557545598147482 0.290114578306178 no 969 0.288577356943992 1433 5911235 SGTC_1721 st082152 9.2685 µM 0.554877437578016 0.29101192429194 no 970 0.289489247724161 1342 5296051 SGTC_1370 2001-0092 44.6 µM 0.552617607155921 0.291772954910363 no 971 0.290262641409995 1574 790957 SGTC_1237 0330-0133 46.1 µM 0.552430644028372 0.291835958963483 no 972 0.29032667011059 1377 X1237 YHR072W ERG7 SGTC_2598 perillyl alcohol 100 µM 0.551980307982263 0.291987742151519 no 973 0.290480922490296 1460 10819 An apoptosis inducer. SGTC_180 1486-1293 102.781 µM 0.551223572648613 0.292242878208434 no 974 0.290740211333992 1523 4140536 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.549229347665158 0.292915734656802 no 975 0.291424033263603 1381 140250 A respiratory chain inhibitor. SGTC_2448 5185112 27.17 µM 0.546212935545738 0.293934843510019 no 976 0.292459787676053 1383 5718189 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.545738030727122 0.29409544158804 no 977 0.292623012942294 1494 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_981 1488-1094 54.9 µM 0.543967501118697 0.2946945369116 no 978 0.293231918453281 1376 3449522 SGTC_291 SEC14.278 35.5 µM 0.543408365018085 0.294883849052365 no 979 0.293424333759349 1475 1068044 SGTC_1846 st056244 14.8 µM 0.542924713920689 0.295047648699039 no 980 0.293590819604007 1454 5393182 SGTC_2978 9011784 42.97 µM 0.540740951369908 0.295787751746895 no 981 0.294343073974921 1533 2994934 SGTC_2782 7736369 71.43 µM 0.540237945345126 0.295958347235297 no 982 0.294516473649072 1446 2950836 YOL077C BRX1 SGTC_16 erodoxin 22.806 µM 0.538588658339916 0.296518022820198 no 983 0.295085357557977 1438 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1958 st076513 41.9 µM 0.538502884181891 0.296547143024681 no 984 0.295114957235457 1365 732122 YGL099W LSG1 SGTC_3308 9128332 17.569 µM 0.537706117080032 0.296817706913425 no 985 0.295389977735031 1526 17332805 YDL196W YDL196W SGTC_2244 6635614 200 µM 0.537229431353553 0.296979632488427 no 986 0.295554571939084 1425 836499 SGTC_785 1270-0111 65.3 µM 0.536064880268806 0.297375389185026 no 987 0.2959568555334 1406 6741994 SGTC_757 1066-0008 322 µM 0.535871316461017 0.29744119252965 no 988 0.296023744750755 1492 6842497 SGTC_1385 3091-4834 14.1 µM 0.535239033091496 0.297656187924233 no 989 0.296242289204932 1465 4072814 SGTC_248 streptozotocin 5.23457 mM 0.530221205073728 0.299364909319747 no 990 0.297979285231673 1502 5300 DNA alkylating agent. SGTC_674 0498-0004 451 µM 0.530010455928639 0.299436772993876 no 991 0.298052340671964 1392 4231473 SGTC_450 aminopyrene 156 nM 0.529860543602322 0.299487896588151 no 992 0.298104312213009 1474 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3004 9076122 71.4286 µM 0.529839974535329 0.299494911427668 no 993 0.298111443410442 1491 44782551 SGTC_1701 st028638 40.4 µM 0.529312895037021 0.299674691122176 no 994 0.298294205864829 1511 3490878 SGTC_826 1683-5028 118 µM 0.528751322934492 0.299866289550373 no 995 0.298488984585348 1463 722377 SGTC_2812 7970281 58.44 µM 0.528193398115911 0.300056698486156 no 996 0.29868255554448 1545 2233435 SGTC_3156 9099931 49.47 µM 0.526533777076007 0.300623418063056 no 997 0.299258695018201 1496 18111053 SGTC_3355 9151058 44.0485 µM 0.526102411540401 0.300770797815524 no 998 0.299408526608812 1426 17015728 SGTC_3240 9133527 49.47 µM 0.525480191741485 0.300983441976993 no 999 0.299624709898984 1421 17617455 SGTC_149 3970-0822 46.1 µM 0.52378360422868 0.3015635963058 no 1000 0.300214529207297 1490 3114250 YBL034C STU1 SGTC_663 1486-0733 13.9 µM 0.521886664852694 0.302212856705015 no 1001 0.300874621775792 1441 722445 YPR165W RHO1 SGTC_2922 7999257 32.47 µM 0.521846324748907 0.30222667061529 no 1002 0.300888666337488 1415 2988377 SGTC_404 fumagillin 50 µM 0.521626377858193 0.302301993368022 no 1003 0.300965246890436 1453 12015870 A methionine aminopeptidase binder. SGTC_781 4335-2806 94.4 µM 0.521318765281379 0.302407352132163 no 1004 0.301072365397708 1577 845254 SGTC_1271 0832-2808 169 µM 0.519068392249596 0.303178615902159 no 1005 0.301856524476627 1519 3663794 SGTC_1617 st002906 78 µM 0.518346222200327 0.303426309438082 no 1006 0.302108364347398 1442 5150859 SGTC_1442 4112-3290 3 µM 0.518264062637298 0.303454494667621 no 1007 0.302137021544041 1432 704353 SGTC_2294 7971431 200 µM 0.517816923282985 0.303607908452398 no 1008 0.302293004818293 1467 5741572 SGTC_2248 tofa 1.1 µM 0.517278024736082 0.303792850873396 no 1009 0.302481046019191 1472 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3082 9117008 49.47 µM 0.51591897027763 0.304259482353527 no 1010 0.302955502022888 1457 41448529 SGTC_1706 st031321 9.9705 µM 0.515705929469987 0.304332658869133 no 1011 0.303029906339284 1530 6103185 SGTC_111 0083-0039 52.457 µM 0.514423896477847 0.304773184500867 no 1012 0.303477827777646 1408 759313 SGTC_2093 5331342 194.4 µM 0.513222831213322 0.305186145386255 no 1013 0.303897728521993 1514 33839 SGTC_3113 9123498 49.47 µM 0.512843151672807 0.305316741808154 no 1014 0.304030521003424 1495 8897275 SGTC_2515 chrysin 20.77 µM 0.511744581291977 0.305694750979315 no 1015 0.304414890333182 1530 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2505 galangin 7.89 µM 0.509847473732781 0.306348017930858 no 1016 0.305079161688112 1405 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2671 danthron 100 µM 0.508334262608852 0.306869532367771 no 1017 0.305609472824495 1442 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1596 piperlongumine 63 µM 0.508184127650605 0.306921296357556 no 1018 0.305662110512892 1568 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2082 5219693 150 µM 0.507065939787139 0.307306949635066 no 1019 0.306054276236827 1447 2834649 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.506697172822724 0.307434180921493 no 1020 0.306183657285805 1414 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1305 1181-0477 144 µM 0.506686007400747 0.307438033555965 no 1021 0.306187575025826 1556 6252086 SGTC_3309 9129340 25.759 µM 0.504950723336869 0.308037052203984 no 1022 0.306796723275019 1547 17158987 SGTC_3207 9114163 49.47 µM 0.504303653692117 0.308260551205822 no 1023 0.307024005172325 1642 849233 SGTC_545 4218-0007 221 µM 0.504284675917633 0.308267107236354 no 1024 0.307030672197068 1465 2840508 SGTC_942 3253-1115 227 µM 0.503996089325681 0.308366809417602 no 1025 0.307132062543911 1562 46497897 SGTC_1569 carminic acid 40.6 µM 0.503792382495769 0.308437195472143 no 1026 0.307203640604951 1525 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2284 7945075 39.21 µM 0.503022737709098 0.308703191483185 no 1027 0.307474143000697 1580 1245402 SGTC_2931 9014674 55.67 µM 0.500307657966818 0.309642348011556 no 1028 0.308429231355696 1434 2996810 SGTC_1355 1499-0035 1.68 µM 0.499116103681259 0.310054904444161 no 1029 0.308848796706625 1454 1548538 SGTC_2324 6149169 200 µM 0.496285512715415 0.311035909383036 no 1030 0.309846493044251 1482 2888231 SGTC_2112 5488546 200 µM 0.494578990382075 0.311627993064194 no 1031 0.310448667786545 1453 600757 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.494062218102117 0.311807385158674 no 1032 0.310631119826127 1529 279621 SGTC_2286 7945697 125 µM 0.493433390330245 0.312025736381632 no 1033 0.310853197102674 1428 1245733 SGTC_1412 3909-8563 178 µM 0.493322320114527 0.312064310752626 no 1034 0.310892429904876 1588 23767530 SGTC_1663 st014140 55.4 µM 0.492177834726119 0.312461907245409 no 1035 0.31129681615205 1559 4207120 SGTC_2517 totarol 10 µM 0.491517688782447 0.312691342613278 no 1036 0.311530172174335 1430 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2208 7283366 200 µM 0.489869068256169 0.313264641678006 no 1037 0.312113276173983 1564 898663 SGTC_3254 9136651 49.47 µM 0.489378518240988 0.313435315090536 no 1038 0.312286870821812 1459 16454030 SGTC_931 2812-0076 566 µM 0.4892941735673 0.313464664531152 no 1039 0.312316722710142 1487 3450959 SGTC_1505 k297-0037 20.6 µM 0.489113942841882 0.313527383427305 no 1040 0.312380515425114 1464 4089396 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.48901800712467 0.313560770512506 no 1041 0.31241447419225 1491 5106787 A p450 inhibitor. SGTC_2221 6807166 181.081 µM 0.488132547081616 0.313868996119562 no 1042 0.312727979369357 1536 674925 SGTC_1690 st023502 41.2 µM 0.487348004831018 0.314142201162041 no 1043 0.313005866933485 1570 24207482 SGTC_69 0096-0274 206.684 µM 0.485957449757116 0.314626691305348 no 1044 0.313498667344851 1586 6741392 SGTC_1320 1313-0481 95.3 µM 0.483534120668399 0.315471778191181 no 1045 0.314358269413903 1552 6813365 YLR208W SEC13 SGTC_246 cycloheximide 667 µM 0.482884141613942 0.315698609705453 no 1046 0.314589001228328 1453 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_236 1509-0011 5.31 µM 0.48008699943087 0.316675555800264 no 1047 0.315582766034455 1528 3107280 SGTC_2095 5432005 200 µM 0.479262181115443 0.316963881330187 no 1048 0.315876061561977 1509 783734 SGTC_1202 1988-0068 29.6 µM 0.476827981134794 0.317815434012354 no 1049 0.316742309489493 1454 2850480 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.476739792105123 0.317846303183764 no 1050 0.316773711835522 1543 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2431 5490079 200 µM 0.476394119903134 0.317967312461105 no 1051 0.316896811506954 1483 5722345 SGTC_1304 1165-0502 251 µM 0.475931517777497 0.318129285745403 no 1052 0.31706158360409 1543 767425 SGTC_3217 9129673 49.47 µM 0.475649333911384 0.318228105332178 no 1053 0.317162111178844 1512 17248312 SGTC_3173 9105693 49.47 µM 0.475159752808924 0.318399585241326 no 1054 0.317336555715861 1568 17096658 SGTC_2305 7443522 69.23 µM 0.475097862275607 0.31842126569389 no 1055 0.317358611061557 1568 5415886 SGTC_3034 9090421 49.47 µM 0.474814179184769 0.3185206487483 no 1056 0.317459712827297 1532 17173761 SGTC_1439 4092-1168 46 µM 0.473614130669213 0.318941207650951 no 1057 0.31788754848842 1536 2886240 SGTC_703 3875-0075 71.8 µM 0.471876884404388 0.319550441451637 no 1058 0.318507334170268 1577 2850814 SGTC_1035 k081-0041 55.2 µM 0.471108587804961 0.319820030428021 no 1059 0.31878159637581 1551 731709 SGTC_3252 9135871 49.47 µM 0.471007432906608 0.319855531947873 no 1060 0.318817713482801 1541 17682838 SGTC_221 trifluoperazine 10.304 µM 0.470639218773153 0.319984775030207 no 1061 0.318949197961724 1509 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1249 0481-0015 10.2 µM 0.468081904893118 0.320882993840058 no 1062 0.319863009455297 1486 4227577 SGTC_639 0833-0042 114 µM 0.467287654773855 0.321162176313468 no 1063 0.320147043851132 1492 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2091 4-phenylthiadiazole 200 µM 0.466546266425873 0.321422868882472 no 1064 0.320412269322398 1545 270010 SGTC_1928 4'-methoxychalcone 40.3 µM 0.465777687195023 0.321693215406649 no 1065 0.320687318967476 1697 641818 SGTC_3040 9091894 49.47 µM 0.461013465606744 0.323371125315329 no 1066 0.322394472115624 1547 25236966 SGTC_352 k048-0007 5.11 µM 0.459449928970651 0.323922572885805 no 1067 0.322955550370551 1520 6811911 SGTC_2893 9048488 25.97 µM 0.459204342826197 0.324009224432889 no 1068 0.323043716117899 1467 6467338 SGTC_1915 st067105 30.6 µM 0.459176912781264 0.324018903322794 no 1069 0.323053564157336 1479 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_517 1365-0151 113 µM 0.45829884915893 0.324328797254663 no 1070 0.323368875415944 1564 768657 SGTC_3235 9132602 49.47 µM 0.458259370984712 0.324342733099703 no 1071 0.323383054948607 1567 4912240 SGTC_568 1193-0097 7.48 µM 0.457827258698134 0.324495285360733 no 1072 0.323538275202111 1491 3646150 SGTC_1461 k072-0203 53.8 µM 0.457440051003908 0.324632009596904 no 1073 0.323677391242456 1480 5418714 SGTC_2153 5569715 200 µM 0.455306133018435 0.325385926285495 no 1074 0.324444507309443 1567 2054701 SGTC_1950 st077106 7.18 µM 0.454822606497876 0.325556856478825 no 1075 0.324618432598428 1512 13831864 SGTC_1678 st019265 80.2 µM 0.453882277281047 0.325889374831291 no 1076 0.324956780077314 1679 5367020 SGTC_3094 9117742 49.47 µM 0.451156558403368 0.326854023068422 no 1077 0.325938358380357 1491 17149698 SGTC_1196 1588-0294 184 µM 0.450982647036785 0.32691561072051 no 1078 0.326001027909725 1511 6144269 SGTC_1641 st009299 47.1 µM 0.449394692640221 0.327478174744118 no 1079 0.326573479622666 1558 4046054 SGTC_505 gw-5074 63.9 µM 0.449320536945056 0.327504455444374 no 1080 0.3266002224742 1632 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1214 0358-0031 63.7 µM 0.447347656877422 0.328203955593213 no 1081 0.327312031265186 1737 4301366 SGTC_2685 mycophenolic acid 18.85 µM 0.447220317695701 0.328249125437919 no 1082 0.327357996448813 1598 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3169 9102970 49.47 µM 0.44628885958637 0.328579609248638 no 1083 0.327694301226229 1591 17027839 SGTC_811 0416-0114 265 µM 0.445954278412746 0.328698352295254 no 1084 0.327815136562019 1559 6612453 SGTC_1718 roemerine 11.9335 µM 0.445770014791046 0.328763754945204 no 1085 0.327881691809879 1526 235224 An aporphine alkaloid with mutagenic activity. SGTC_2301 7769476 200 µM 0.445623851155069 0.32881563809163 no 1086 0.327934489390945 1617 977820 SGTC_2240 6690706 185.951 µM 0.444435210998537 0.329237687571133 no 1087 0.328363980476116 1479 805876 SGTC_1084 voriconazole 435 nM 0.442871457940207 0.32979325963669 no 1088 0.328929356626155 1599 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_125 0133-0007 11.75 µM 0.441722774845508 0.330201604604271 no 1089 0.329344913499049 1745 26541 SGTC_1843 st055809 45.5 µM 0.440961498583528 0.330472341961291 no 1090 0.329620435180337 1542 16413835 SGTC_61 0978-8327 98.565 µM 0.440261840371316 0.330721243983146 no 1091 0.329873737591573 1584 6150059 YHR072W ERG7 SGTC_1025 k007-0731 70 µM 0.438718452861543 0.331270565640943 no 1092 0.330432777326925 1538 6256118 SGTC_1434 4073-0095 163 µM 0.437544596370997 0.331688607314591 no 1093 0.330858220572897 1573 24133745 SGTC_3135 9127742 49.47 µM 0.437364881513941 0.331752627101382 no 1094 0.330923374306437 1556 3643468 SGTC_593 1203-0218 61.7 µM 0.436255837774007 0.332147810193776 no 1095 0.331325559719025 1671 3666956 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.434606155262049 0.332735983288052 no 1096 0.331924163211568 1545 4330530 SGTC_1004 4084-0029 199 µM 0.433610929512168 0.333091017547485 no 1097 0.332285498359671 1689 716894 YLR208W SEC13 SGTC_1687 st020778 55.3625 µM 0.433610451246414 0.333091188198772 no 1098 0.332285672040431 1592 4259299 SGTC_2425 5628681 7.85 µM 0.432996538887437 0.333310268399494 no 1099 0.332508642138871 1666 5714958 SGTC_1266 0828-0227 32.9 µM 0.431845665771655 0.333721121139477 no 1100 0.332926793544539 1624 3913820 SGTC_1860 st056228 74.6 µM 0.431465986060232 0.333856707619662 no 1101 0.333064789740396 1545 688679 SGTC_2904 7225135 42.03 µM 0.43139198427919 0.333883136738969 no 1102 0.333091688633657 1620 4446116 SGTC_1457 k015-0032 57.3 µM 0.4300434570332 0.33436489622019 no 1103 0.333582014829134 1568 4302660 SGTC_2165 5727197 32.143 µM 0.429482211412703 0.334565480916623 no 1104 0.333786168305305 1652 1361712 SGTC_320 4092-0846 5.34 µM 0.429138333991987 0.334688403294158 no 1105 0.333911278269782 1627 1359356 SGTC_1156 4092-0367 4.88 µM 0.428935835044431 0.334760796831291 no 1106 0.333984960358845 1608 1357585 SGTC_1295 1013-0063 9.78 µM 0.428813557903171 0.334804513982265 no 1107 0.334029455715183 1693 6826038 SGTC_1864 st057645 30.4 µM 0.42577605301556 0.335891215638396 no 1108 0.335135519026448 1627 688666 SGTC_3001 9076041 71.4286 µM 0.425674294573817 0.335927644695118 no 1109 0.335172597711998 1570 16004211 SGTC_313 3474-0040 5.03 µM 0.424970477138838 0.336179650302711 no 1110 0.335429098280541 1548 1043375 YIL048W NEO1 SGTC_337 1315-0038 354 µM 0.424938129389967 0.336191234358537 no 1111 0.33544088900098 1583 1626437 SGTC_271 rotenone 740 µM 0.424520468333508 0.336340816970855 no 1112 0.335593140569082 1634 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1134 3477-0009 42.5 µM 0.423579037400125 0.336678079378604 no 1113 0.335936422933161 1773 3973534 SGTC_1431 4049-0260 9.09 µM 0.420862957995695 0.337651835377767 no 1114 0.336927577658657 1614 3854841 SGTC_2378 9074213 121.43 µM 0.41979252157052 0.3380359024395 no 1115 0.337318514275415 1568 657714 SGTC_1849 st056239 19.2 µM 0.417798670927188 0.338751735135136 no 1116 0.338047161355122 1494 5393181 SGTC_2807 7945238 51.95 µM 0.416518011836729 0.339211825215991 no 1117 0.338515495023394 1638 17148797 SGTC_681 1642-0006 26.6 µM 0.415400327099842 0.339613561112604 no 1118 0.338924433628043 1564 4446530 SGTC_563 tetrahydrosecaminediol 614 µM 0.415362621783928 0.33962711693363 no 1119 0.33893823256659 1701 334274 A psychoactive constituent of the cannabis plant. SGTC_2732 terfenadine 20 µM 0.415215535972679 0.339679999230268 no 1120 0.338992063330465 1626 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_809 3998-0021 90 µM 0.415212335544218 0.339681149927038 no 1121 0.338993234666322 1685 715485 SGTC_3078 9116413 49.47 µM 0.414744088123348 0.339849521855431 no 1122 0.339164626924052 1549 17177322 SGTC_616 4092-0450 108 µM 0.413011857718579 0.340472673031688 no 1123 0.339798963051475 1639 787165 SGTC_2393 9031399 185.94 µM 0.41247538245518 0.340665752672641 no 1124 0.339995510380508 1678 1526623 YDL150W RPC53 SGTC_3104 9120930 49.47 µM 0.410798599472293 0.341269502750551 no 1125 0.340610110109559 1619 17014836 SGTC_62 0180-0423 3.232 µM 0.410704957793743 0.341303231797191 no 1126 0.340644445565552 1637 30102 YGL099W LSG1 SGTC_1798 st045719 60.953 µM 0.409570881750791 0.341711818262218 no 1127 0.341060380318847 1633 3980186 SGTC_2264 7948757 110.76 µM 0.409227863168148 0.341835438029175 no 1128 0.341186224207789 1562 2971411 SGTC_2790 5423970 71.43 µM 0.408506717335025 0.342095385603238 no 1129 0.341450849967446 1713 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_700 3453-2283 142 µM 0.408489849499446 0.342101466757924 no 1130 0.341457040583658 1697 565664 SGTC_1014 4130-3005 69.3 µM 0.40804571214854 0.342261600902575 no 1131 0.341620057509184 1594 743608 SGTC_2640 pentamidine 10.38 µM 0.407046940419152 0.3426218125873 no 1132 0.341986756264771 1749 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1123 mangostin 811.285 nM 0.403195503633498 0.344012189157847 no 1133 0.343402203597956 1592 5281650 An antioxidant. SGTC_718 1130-0073 349 µM 0.402892816285374 0.344121549654054 no 1134 0.343513538142631 1691 6740020 SGTC_1857 st056007 79.3 µM 0.40109255105729 0.344772251957426 no 1135 0.344175992444176 1639 619834 SGTC_365 0121-0052 13.6 µM 0.399537896259929 0.345334548674549 no 1136 0.34474845312185 1663 3101739 SGTC_897 1000-0139 31.4 µM 0.39930614269905 0.345418399951706 no 1137 0.344833820757865 1745 6151020 SGTC_1342 1486-1464 234 µM 0.398003258397452 0.345889940568983 no 1138 0.345313891945987 1615 3253938 SGTC_2523 spermine 47.74 µM 0.396206746397109 0.346540527276589 no 1139 0.345976257399658 1758 1103 A DNA binding polyamine. SGTC_1922 5578187 25 µM 0.39548369076731 0.346802501716967 no 1140 0.346242977792563 1733 1350412 SGTC_324 1315-0088 19.6 µM 0.394200364513559 0.347267651369924 no 1141 0.346716558296721 1671 6787421 SGTC_827 3253-0474 693 µM 0.393588323046888 0.347489570740333 no 1142 0.346942501829433 1748 5402065 SGTC_2359 9039622 200 µM 0.393585464960649 0.347490607173045 no 1143 0.346943557059059 1699 6463596 SGTC_2875 9039966 71.43 µM 0.393560468877757 0.347499671594014 no 1144 0.346952785874985 1740 6463691 SGTC_3154 9100113 49.47 µM 0.390223555865551 0.348710529597046 no 1145 0.348185622275365 1593 25237525 SGTC_772 k072-0172 35.3 µM 0.389733993144992 0.348888306167139 no 1146 0.348366628663045 1533 5861980 SGTC_2472 5377652 49.4 µM 0.389670389277745 0.348911405291074 no 1147 0.348390147503984 1613 1610903 SGTC_3161 9100388 49.47 µM 0.389215968301084 0.34907645441193 no 1148 0.348558195981515 1704 25236368 SGTC_464 bw-b 70c 158 µM 0.388072041151114 0.349492063719818 no 1149 0.348981360835611 1718 5353454 SGTC_451 chloral hydrate 100 µM 0.388007043110806 0.349515684100583 no 1150 0.349005410745359 1687 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_601 0986-0029 62.9 µM 0.387918805501457 0.349547750706362 no 1151 0.349038060493218 1644 24747981 SGTC_2032 5185112 25.99 µM 0.386718997386063 0.349983881834647 no 1152 0.349482125236168 1661 5718189 SGTC_2618 avocadyne 43.43 µM 0.385910049849658 0.350278046634388 no 1153 0.349781643696566 1723 3015189 SGTC_74 000s-0487 160.283 µM 0.383438111612258 0.351177495626442 no 1154 0.350697474842396 1560 677548 SGTC_812 4251-0442 148 µM 0.383103762634453 0.351299217300084 no 1155 0.350821414950336 1724 5723007 SGTC_2661 dactinomycin 12.96 µM 0.381359894650369 0.351934329507646 no 1156 0.351468107946053 1667 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1809 st050081 57.6 µM 0.380686818369184 0.352179572801025 no 1157 0.35171782555614 1720 5036894 SGTC_2980 9014342 25.29 µM 0.380451595099465 0.352265293682016 no 1158 0.351805110689207 1661 2996599 SGTC_1365 1672-3266 55.4 µM 0.38035397463412 0.352300871075243 no 1159 0.351841337355458 1744 6415873 SGTC_1727 st034309 9.9045 µM 0.380179350562063 0.35236451535272 no 1160 0.351906143187633 1778 870305 SGTC_752 1896-0090 130 µM 0.379662526819316 0.352552903485276 no 1161 0.352097970085299 1648 772567 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.379646598725451 0.352558710031443 no 1162 0.352103882634841 1744 688662 SGTC_670 4204-0025 119 µM 0.378798757771438 0.352867837852981 no 1163 0.352418654955295 1723 719039 SGTC_1075 aripiprazole 15.2 µM 0.37878593036551 0.352872515547541 no 1164 0.352423418078635 1645 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1978 st071761 42 µM 0.377505824836489 0.35333943583407 no 1165 0.352898868235526 1616 5147680 SGTC_1521 st012942 49.4 µM 0.375764103452025 0.353975085692594 no 1166 0.353546138298112 1838 24207259 SGTC_1285 0929-0069 65.5 µM 0.374714676782098 0.354358275872904 no 1167 0.353936337894104 1668 1206237 SGTC_3318 9139014 38.6185 µM 0.373943279629121 0.354640039762022 no 1168 0.354223257973668 1664 16643984 SGTC_744 1594-0068 283 µM 0.372767300675821 0.355069736002454 no 1169 0.354660820915418 1662 668392 SGTC_534 k292-0788 63.4 µM 0.371836243753929 0.355410069893116 no 1170 0.355007388395329 1844 4146317 SGTC_2345 9052315 157.45 µM 0.371019894489298 0.355708569029696 no 1171 0.35531135696942 1673 6469265 SGTC_911 3456-4043 236 µM 0.370534058452875 0.355886257608774 no 1172 0.355492302286228 1742 914281 SGTC_56 0957-0365 83.25 µM 0.370252930430821 0.355989091043035 no 1173 0.355597020802573 1667 6752360 SGTC_1040 k898-0338 155 µM 0.370079802531448 0.356052424473801 no 1174 0.355661515339432 1840 20969351 SGTC_1970 st070122 35.8 µM 0.369528249205258 0.356254219495638 no 1175 0.355867010497943 1719 102928 SGTC_2357 9067248 200 µM 0.369469027216597 0.356275889246632 no 1176 0.355889077640671 1706 9150235 SGTC_2228 7354201 200 µM 0.369249243389275 0.35635631378452 no 1177 0.355970977136905 1754 753451 SGTC_3160 9100216 49.47 µM 0.368196705149646 0.356741553022074 no 1178 0.356363283474525 1690 17191039 SGTC_606 k015-0008 38.6 µM 0.366939517207552 0.357201887582405 no 1179 0.356832066938925 1785 1970475 SGTC_2201 6605497 169.863 µM 0.366534378834278 0.35735027822569 no 1180 0.356983182090215 1743 670741 SGTC_3224 9130643 49.47 µM 0.366397990860776 0.35740023810943 no 1181 0.357034059362382 1740 17644395 SGTC_1676 st018489 23.4 µM 0.366121626853942 0.357501479702123 no 1182 0.357137160167734 1687 3696235 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.364442820990145 0.358116699009649 no 1183 0.357763682135366 1734 5393153 SGTC_1587 estradiol valerate 56.1 µM 0.364001962527277 0.358278318254211 no 1184 0.357928271942704 1810 13791 A steroid. SGTC_2316 5844804 197.44 µM 0.362159938670804 0.358953880849261 no 1185 0.358616257347563 1822 776813 SGTC_2048 5246248 200 µM 0.360652287565072 0.359507140767234 no 1186 0.359179698195131 1793 677046 SGTC_1456 k015-0012 13 µM 0.35978750747454 0.359824620554268 no 1187 0.359503023029299 1862 2989616 SGTC_1640 st009078 66.4 µM 0.359456933667492 0.359946007038662 no 1188 0.359626644883805 1763 690618 SGTC_3293 9120939 62.045 µM 0.359127699491528 0.360066915651676 no 1189 0.359749780369282 1737 934087 SGTC_2355 9061122 103.12 µM 0.358595237387194 0.360262487719699 no 1190 0.359948955085249 1801 5302957 SGTC_848 0368-0089 85.6 µM 0.35791742865228 0.360511498165551 no 1191 0.360202553709148 1763 762535 SGTC_1526 st051518 75 µM 0.357765262529859 0.360567408434609 no 1192 0.360259494335748 1676 673993 SGTC_232 clozapine 119 µM 0.356219557492502 0.361135514272216 no 1193 0.360838073284979 1710 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1902 st060212 70.5 µM 0.355650784378179 0.361344637379251 no 1194 0.361051053258886 1668 688944 SGTC_414 piperonyl butoxide 100 µM 0.355375424014826 0.361445895125773 no 1195 0.361154178824814 1648 5794 A potent inhibitor of cytochrome P450. SGTC_2016 5121758 140 µM 0.353484944522095 0.36214133929341 no 1196 0.361862456869132 1671 2795203 SGTC_1963 st076565 50.3 µM 0.352830730554178 0.362382108895641 no 1197 0.362107671945481 1673 4914280 SGTC_3265 9137266 49.47 µM 0.352312080560555 0.362573025743757 no 1198 0.362302114628067 1854 17224265 SGTC_208 k072-0098 12.366 µM 0.352083312506292 0.362657246916773 no 1199 0.362387891420286 1708 5948901 SGTC_508 roscovitine 141 µM 0.351917959669589 0.362718125856035 no 1200 0.362449894920401 1744 160355 A CDKinase inhibitor. SGTC_1160 4092-0570 10.5 µM 0.351154240519271 0.36299935389665 no 1201 0.362736318782199 1632 4994975 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.350226697200138 0.363341007072436 no 1202 0.363084286263732 1859 688664 SGTC_170 4197-0004 226 µM 0.348623611842867 0.363931747021168 no 1203 0.363685949453396 1765 218692 SGTC_2860 9025725 38.96 µM 0.348311742597768 0.36404670905667 no 1204 0.363803038018594 1632 40546248 SGTC_2398 5228213 48.84 µM 0.346763213852103 0.364617712699075 no 1205 0.364384607698332 1881 80771 YMR134W ERG29 SGTC_3304 9125678 46.087 µM 0.346487935432295 0.364719250205788 no 1206 0.364488024748186 1673 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2148 5546263 113.568 µM 0.346147735801487 0.364844747262212 no 1207 0.364615845133108 1716 792097 SGTC_2803 7707263 71.43 µM 0.345666787659956 0.365022190079718 no 1208 0.364796573468056 1672 2199229 SGTC_187 1488-2104 32.728 µM 0.343964267851174 0.365650556208433 no 1209 0.365436579217206 1783 2852859 SGTC_871 0574-0004 149 µM 0.343378142307552 0.365866967010921 no 1210 0.365657000472105 1717 9551173 SGTC_2945 9067681 61.76 µM 0.343214503006986 0.365927393966062 no 1211 0.365718547397725 1743 16456930 SGTC_408 cantharidin 100 µM 0.342733243890074 0.366105127409719 no 1212 0.365899575403801 1748 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2735 sertaconazole 140 nM 0.342627498047785 0.366144184179069 no 1213 0.365939356230254 1802 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2838 9002687 71.43 µM 0.340962818828381 0.366759208770439 no 1214 0.366565786284276 1647 6457060 SGTC_179 1273-0063 6.77 µM 0.339968450241752 0.367126746901428 no 1215 0.366940143684113 1670 3108139 SGTC_3315 9136395 68.55 µM 0.339930829516487 0.367140654652613 no 1216 0.366954309527764 1868 16876844 SGTC_2513 baicalein 25.65 µM 0.339859132020618 0.36716716049709 no 1217 0.366981307263194 1630 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1390 3413-2614 145 µM 0.339592728174849 0.367265652869993 no 1218 0.367081627554938 1709 3421432 SGTC_2865 9030313 51.95 µM 0.339504809815734 0.367298159152094 no 1219 0.36711473716021 1650 42562754 SGTC_2894 9048625 32.47 µM 0.338016902939716 0.367848430882282 no 1220 0.367675225005245 1831 4092861 SGTC_2479 5617353 43.85 µM 0.336684091295876 0.3683415742712 no 1221 0.368177528611391 1775 2731746 SGTC_2951 9072950 58.06 µM 0.336118892825438 0.368550764574769 no 1222 0.368390605998106 1790 16488155 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.335998153164041 0.368595457587251 no 1223 0.368436129579759 1788 5357218 A potent inhibitor of glutathione S-transferases. SGTC_602 3130-1533 38.1 µM 0.335611872832588 0.368738455114771 no 1224 0.368581784798151 1813 720941 SGTC_2713 st079149 53.4 µM 0.334896363680704 0.369003378211586 no 1225 0.36885163261958 1748 3103253 SGTC_1208 2323-2347 50.3 µM 0.334857597467062 0.3690177334969 no 1226 0.368866254795216 1851 5412760 SGTC_3264 9137442 49.47 µM 0.334770316873192 0.369050054521664 no 1227 0.368899176738983 1813 17015726 SGTC_1774 st048371 48.465 µM 0.331041135489466 0.370431876207356 no 1228 0.3703067070015 1681 4242727 SGTC_590 k048-0076 22.4 µM 0.329994724835787 0.370819917695292 no 1229 0.37070197402169 1820 6832814 SGTC_735 3076-0345 636 µM 0.329304381230957 0.371075990468244 no 1230 0.370962816446031 1825 2888990 SGTC_1935 st074532 41.6 µM 0.329096813874678 0.37115299568565 no 1231 0.371041256198375 1901 2829742 SGTC_2918 7977171 22.06 µM 0.328361171713254 0.371425952399386 no 1232 0.371319298670128 1721 2236483 SGTC_224 benfluorex 43.875 µM 0.328092442060746 0.371525679462344 no 1233 0.371420884180518 1837 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2818 7996756 12.99 µM 0.327987596449895 0.371564590588533 no 1234 0.371460520475345 1699 2241621 SGTC_2220 6782180 200 µM 0.327890224483356 0.371600729212586 no 1235 0.371497332621648 1834 833803 SGTC_2328 6201408 200 µM 0.327691570211225 0.371674461252847 no 1236 0.371572438889621 1705 2890418 SGTC_2877 9040724 71.43 µM 0.327646715289539 0.371691110148931 no 1237 0.371589398103067 1868 6463895 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.326278446566463 0.372199088522763 no 1238 0.372106846935824 1681 5355888 SGTC_186 3455-3465 67.277 µM 0.325623453924384 0.372442337460032 no 1239 0.372354632433195 1736 755278 SGTC_1446 4239-0190 62 µM 0.32464340311685 0.372806400415002 no 1240 0.372725486996308 1712 1340085 SGTC_2714 st079313 56.9 µM 0.324502700814018 0.372858676935405 no 1241 0.37277873892183 1730 2939799 SGTC_1257 0669-0121 16 µM 0.324364894600903 0.372909879712617 no 1242 0.372830897114486 1846 4307855 SGTC_3013 9080133 71.4286 µM 0.324199689870502 0.372971265542806 no 1243 0.372893428428677 1792 17050193 SGTC_1742 st038235 28.8875 µM 0.324030293701847 0.373034212152832 no 1244 0.37295754971358 1735 564103 YBR002C RER2 SGTC_458 nppb 133 µM 0.323011438275539 0.37341288422554 no 1245 0.373343289763908 1909 4549 A chloride channel blocker. SGTC_258 haloperidol 50.781 µM 0.32290321796498 0.373453113029092 no 1246 0.373384269586365 1689 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2406 ethylparaben 405.7 µM 0.32241232294908 0.373635611050606 no 1247 0.373570174946438 1510 8434 A possible steroid mimic. SGTC_2011 4012611 177 µM 0.3206856278446 0.374277762295752 no 1248 0.374224319920552 1682 2049887 SGTC_403 arphamenine a 50 µM 0.319816432628945 0.374601144796942 no 1249 0.374553744957114 1787 5487158 An arginine aminopeptidase inhibitor. SGTC_1291 0993-0025 5.79 µM 0.319781331162365 0.374614206088508 no 1250 0.374567050340469 1836 4353356 SGTC_356 1634-0012 32.5 µM 0.319288354474003 0.374797658409259 no 1251 0.374753931347349 1918 735457 SGTC_177 1327-0068 8.361 µM 0.319074610284237 0.374877208236196 no 1252 0.374834968115608 1727 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2312 7706453 155.7 µM 0.318227839644616 0.375192405740084 no 1253 0.375156058291312 1730 976098 SGTC_1724 st037281 8.293 µM 0.317299830950521 0.375537938607291 no 1254 0.375508052811702 1699 574124 YDL195W SEC31 SGTC_1253 0550-0034 176 µM 0.317242178669126 0.375559408037705 no 1255 0.375529923796002 1752 5969915 SGTC_1274 0865-0114 173 µM 0.316019297166352 0.376014893867165 no 1256 0.375993930564319 1773 870624 SGTC_2291 7917025 104.35 µM 0.315189784244811 0.376323960365841 no 1257 0.376308780778419 1698 2964612 SGTC_1904 st060225 78 µM 0.314896188632709 0.376433369561152 no 1258 0.376420237768063 1727 66595 SGTC_3159 9100096 49.47 µM 0.31481472485304 0.376463729017948 no 1259 0.376451165491722 1709 25236875 SGTC_1574 spiramycin 23.7 µM 0.314551768772796 0.376561731204005 no 1260 0.37655100217805 1707 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2512 diallyl trisulfide 49.23 µM 0.313802168224407 0.376841146574113 no 1261 0.376835648753455 1775 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1818 st052136 56.3 µM 0.312347083942154 0.377383716729853 no 1262 0.377388380408325 1707 674169 SGTC_418 lividomycin a 100 µM 0.311190530337079 0.377815143865075 no 1263 0.377827890796699 1869 72394 An antibiotic. SGTC_3184 9108758 49.47 µM 0.310748936294237 0.377979911153225 no 1264 0.377995745941958 1766 902885 SGTC_1120 ficusin 1.78878 µM 0.310595667822312 0.378037103778827 no 1265 0.378054010496721 1850 6199 A DNA cross-linker. SGTC_2423 st077119 87.2 µM 0.310520555046394 0.378065133329947 no 1266 0.378082565408407 1757 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2138 5575593 77.673 µM 0.310425953598973 0.378100436308295 no 1267 0.37811853009115 1724 762213 SGTC_3008 9078912 71.4286 µM 0.309613528456582 0.37840365565109 no 1268 0.378427433643402 1746 16648731 SGTC_921 1561-0023 372 µM 0.30908819076973 0.378599765965051 no 1269 0.3786272210328 1704 24050882 SGTC_1838 st055369 84.5 µM 0.308022940790866 0.378997523276613 no 1270 0.379032438114606 1740 676036 SGTC_2644 guaiazulene 100 µM 0.306917909657188 0.379410270044889 no 1271 0.379452928316628 1859 3515 A coloring agent. SGTC_1686 st019653 115.5 µM 0.306758556636203 0.379469802294978 no 1272 0.379513577648187 1885 97252 SGTC_941 3237-0776 460 µM 0.304988899836579 0.380131115224283 no 1273 0.38018730323579 1880 760008 SGTC_900 1112-0045 141 µM 0.304622865437447 0.380267944484344 no 1274 0.380326701558267 1855 56211 YIL048W NEO1 SGTC_2257 7960413 200 µM 0.303598745421508 0.380650855781889 no 1275 0.380716803751193 1836 2974689 YIL048W NEO1 SGTC_3306 9127676 59.7925 µM 0.30358115760293 0.380657432766497 no 1276 0.380723504267429 1744 41905287 SGTC_1283 0922-0125 16.4 µM 0.301601862047625 0.381397812500789 no 1277 0.381477794175697 1840 3360884 SGTC_90 0870-0863 4.608 µM 0.301505216121539 0.381433975233592 no 1278 0.381514636535011 1730 1738164 SGTC_947 3447-0010 211 µM 0.300755340206484 0.381714597094124 no 1279 0.381800532924174 1785 748350 SGTC_634 1611-4317 11.2 µM 0.300066161953779 0.381972559244604 no 1280 0.382063344698469 1913 2843522 SGTC_1879 gemcitabine 100 µM 0.299858115768801 0.382050442059992 no 1281 0.382142691879533 1815 60750 A nucleoside analog which inhibits DNA replication. SGTC_154 3389-1638 511.116 µM 0.299525492605154 0.382174970617334 no 1282 0.382269562024443 1663 5238686 SGTC_2017 5132927 60.65 µM 0.298349657626795 0.382615281219958 no 1283 0.382718153837311 1714 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_448 monastrol 171 µM 0.295989500259401 0.383499538242191 no 1284 0.383619049953637 1836 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3012 9080433 71.4286 µM 0.294840129780891 0.383930381737166 no 1285 0.384058004611008 1931 17688859 SGTC_647 0140-0236 81 µM 0.294537696348601 0.384043773296768 no 1286 0.384173531335061 1820 990837 SGTC_106 0092-0003 11.579 µM 0.290008945741998 0.385742922844679 no 1287 0.385904696928902 1908 1072148 SGTC_780 0109-0199 192 µM 0.289775919818718 0.385830411878419 no 1288 0.385993835519788 1929 610414 SGTC_2911 7942208 15.64 µM 0.289614110686587 0.38589116615262 no 1289 0.386055735342077 1759 1243384 SGTC_1184 1269-1718 139 µM 0.288937817404794 0.386145123432887 no 1290 0.386314481627445 1896 5403821 SGTC_2107 5363541 170.161 µM 0.288903742851955 0.386157920180607 no 1291 0.386327519712744 1835 244052 SGTC_2679 rapamycin 1 nM 0.288690014063857 0.386238189161012 no 1292 0.386409302558536 1814 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1516 st013856 110 µM 0.287661202504649 0.386624642503885 no 1293 0.386803045563492 1819 5281404 A mutagen and neurotoxin. SGTC_1145 3546-0597 10.2 µM 0.286149448163416 0.387192707991359 no 1294 0.387381830007067 1811 875334 SGTC_1591 genipin 88.4 µM 0.28542385228146 0.387465447975358 no 1295 0.38765971787105 1872 442424 A DNA cross-linking agent. SGTC_2247 cerulenin 830 nM 0.284843019215225 0.38768381395105 no 1296 0.387882206125207 1885 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_925 2064-1272 59.6 µM 0.284558572952171 0.387790765362359 no 1297 0.38799117677148 1761 6815817 SGTC_2600 tangeritin 87.95 µM 0.283848997939926 0.38805760170233 no 1298 0.388263051599207 1733 68077 A bioactive flavone. SGTC_2480 5767542 37.17 µM 0.282709467367189 0.388486233788731 no 1299 0.388699779144054 1855 2867358 SGTC_2779 methotrexate 400 µM 0.282427910928567 0.388592161612035 no 1300 0.388807707954974 1900 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3153 9100258 49.47 µM 0.280871563886235 0.389177843418344 no 1301 0.389404455887927 1747 25236848 SGTC_2565 isoliquiritigenin 100 µM 0.280732165995719 0.389230313699465 no 1302 0.389457917773884 1681 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_96 0929-0093 37.281 µM 0.280651261602867 0.389260767570475 no 1303 0.389488947190257 1767 6991579 SGTC_861 0443-0273 110 µM 0.280448459466067 0.389337108937592 no 1304 0.389566731377463 1871 6149169 SGTC_644 1498-1197 63.3 µM 0.280040339260058 0.389490751695198 no 1305 0.389723278137619 1875 6741615 SGTC_565 1418-0001 44.5 µM 0.275233481836063 0.391301656555741 no 1306 0.391568432574478 1898 2862145 SGTC_1805 st050013 60.3 µM 0.273713038469053 0.39187495162604 no 1307 0.392152578516651 1910 4037144 SGTC_519 k048-0011 62.8 µM 0.273339524250684 0.392015824066281 no 1308 0.392296117867549 1841 6836379 SGTC_603 3794-0023 45.9 µM 0.273318077884885 0.392023913082221 no 1309 0.392304360026798 1934 3802260 SGTC_1781 st038725 66.3 µM 0.272648045063657 0.392276655665861 no 1310 0.392561887980338 1769 4270275 YIL048W NEO1 SGTC_1229 0139-0193 12.2 µM 0.272458244389289 0.392348258502797 no 1311 0.392634846663459 1945 3090752 SGTC_1793 st048256 72.231 µM 0.272242875882788 0.392429511290301 no 1312 0.392717638096956 1863 672022 SGTC_1419 3993-2473 62.6 µM 0.272033515412273 0.392508501901341 no 1313 0.392798124589186 1849 704026 SGTC_253 dyclonine 31.25 µM 0.27153906445041 0.392695073238356 no 1314 0.392988229397484 1885 3180 An oral anasthetic. SGTC_2864 9034755 47.6 µM 0.271251580703623 0.392803560910534 no 1315 0.393098771899295 1981 4930451 SGTC_3138 9097216 49.47 µM 0.268973469643615 0.393663544959929 no 1316 0.393975049357868 2001 25237486 SGTC_193 1273-0060 1.558 µM 0.268145610592164 0.393976189482557 no 1317 0.394293619360448 1922 2847393 YHR072W ERG7 SGTC_3059 1327-0034 3 µM 0.267821045942406 0.394098781375322 no 1318 0.394418535006229 1778 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3021 9087658 49.47 µM 0.266614687120182 0.394554529209696 no 1319 0.394882923085451 1951 25237042 SGTC_879 0831-1030 162 µM 0.265110767441619 0.395122894063604 no 1320 0.395462066408371 1798 1549252 SGTC_2175 5807670 165.306 µM 0.26498495108012 0.395170453012733 no 1321 0.395510527424218 1952 241186 SGTC_1262 0737-0114 49.6 µM 0.264807413067327 0.395237565552298 no 1322 0.395578912951617 1975 765919 SGTC_548 1436-0017 110 µM 0.264404784553382 0.395389777833541 no 1323 0.395734012568795 1946 9677137 SGTC_1802 st050112 57.9 µM 0.264126596689348 0.395494955093479 no 1324 0.395841185096195 1916 4662563 SGTC_2683 piperine 63.03 µM 0.263741459356328 0.395640580368511 no 1325 0.395989573154121 1852 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_191 3914-0123 66.505 µM 0.261914306325536 0.396331648142363 no 1326 0.396693754842446 1812 3144412 SGTC_1740 st038286 13.222 µM 0.261810038778689 0.396371094173872 no 1327 0.396733949565884 1873 716786 SGTC_46 0329-0187a 2.197 µM 0.260157673636728 0.396996350915473 no 1328 0.397371075945529 1891 46494817 SGTC_2188 6126565 140.678 µM 0.260111329986458 0.397013891228336 no 1329 0.397388949295492 1930 874518 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.259060701743793 0.397411592647809 no 1330 0.397794202701245 1844 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1472 k841-0093 193 µM 0.258694767429608 0.39755013730884 no 1331 0.397935378578389 1938 X1472 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.258379933634577 0.397669345387788 no 1332 0.398056850792586 1857 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2272 7805186 180 µM 0.257552010662992 0.397982874172743 no 1333 0.398376335158394 1999 2956062 YPR165W RHO1 SGTC_1746 st038117 42 µM 0.256872063659364 0.39824041475536 no 1334 0.398638768546982 1830 2898218 SGTC_2923 7992654 58.14 µM 0.256423135718293 0.398410477554204 no 1335 0.398812062594972 1831 2985126 SGTC_1513 0337-0559 19 µM 0.255100917115476 0.398911472151776 no 1336 0.399322577919609 1779 775073 SGTC_1 0258-0098 57.368 µM 0.25407884037824 0.399298855846661 no 1337 0.399717325007579 1858 6790032 YDR047W HEM12 SGTC_1759 st043059 70 µM 0.253849063454891 0.399385958703373 no 1338 0.399806083717198 1783 669426 SGTC_340 k038-0059 454 µM 0.253515787788073 0.399512304322426 no 1339 0.399934831336914 1875 23733424 SGTC_1155 4088-0394 48.2 µM 0.25192581825991 0.400115210305906 no 1340 0.40054920148675 1815 2326248 SGTC_278 4092-0821 23.9 µM 0.250770278806332 0.400553532783214 no 1341 0.400995860766924 1926 877900 SGTC_3086 9117350 49.47 µM 0.250555984422586 0.400634833317045 no 1342 0.401078707818598 1867 2679265 SGTC_1898 st060199 18.6 µM 0.250006043621961 0.400843493476468 no 1343 0.401291337442919 1816 688866 SGTC_346 4513-0042 7.16 µM 0.249585092976549 0.401003230931242 no 1344 0.401454113950677 1828 2827372 SGTC_2383 9036125 200 µM 0.248351039074957 0.401471610643734 no 1345 0.401931406083982 1881 79580 SGTC_1671 st016596 74.5 µM 0.24785719316653 0.401659087387675 no 1346 0.402122450734545 1871 2829167 SGTC_1481 3346-2004 36 µM 0.247731240082342 0.401706906076954 no 1347 0.402171179521784 1943 2770522 SGTC_1294 1000-1494 117 µM 0.247245909675454 0.401891177836664 no 1348 0.402358958583958 1820 712797 YDL207W GLE1 SGTC_1200 1643-0193 18.4 µM 0.245873096019779 0.402412529982284 no 1349 0.402890235441759 1981 5403974 SGTC_336 4111-0029 111 µM 0.245070381917264 0.402717456463878 no 1350 0.403200967772298 1835 3131175 SGTC_2946 9065502 71.43 µM 0.244132080214494 0.403073963535345 no 1351 0.403564263831966 1916 16489101 SGTC_1050 3232-1156 69.3 µM 0.239975613612618 0.404654175368452 no 1352 0.405174580898797 1841 700529 SGTC_1624 st003710 6.25 µM 0.238768626244424 0.405113342415967 no 1353 0.405642499643895 1981 24207033 SGTC_2592 piperlongumine 83.33 µM 0.238742037881385 0.405123458742281 no 1354 0.405652808806291 1808 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_649 1123-0311 367 µM 0.238733708920647 0.4051266277539 no 1355 0.405656038225365 1980 693629 YIL048W NEO1 SGTC_2368 9071271 200 µM 0.238001137485162 0.405405381606559 no 1356 0.405940105982301 1818 27209959 SGTC_646 4092-0839 27.3 µM 0.23633635016966 0.40603903509181 no 1357 0.406585841178735 1961 877796 SGTC_662 k832-1615 104 µM 0.235409829108361 0.406391795483701 no 1358 0.406945328947396 1920 5878478 SGTC_721 1187-1332 279 µM 0.235333018997248 0.406421043311931 no 1359 0.406975134595211 1863 25730 SGTC_2943 9068529 45.32 µM 0.235031484349504 0.406535867012674 no 1360 0.407092148297897 1958 3270634 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.234478502634825 0.406746462055929 no 1361 0.407306760231356 1951 16623 A steroid. SGTC_1194 1488-0194 225 µM 0.234444658027364 0.406759352158907 no 1362 0.407319896211356 1889 1391452 SGTC_815 1582-0027 36.9 µM 0.232560435570373 0.407477138647891 no 1363 0.408051376396691 1932 3128206 SGTC_2816 7982706 58.44 µM 0.232232082461786 0.4076022552239 no 1364 0.408178880306823 1866 2981853 SGTC_261 5-fluorouridine 15.376 µM 0.231356952024227 0.407935763348026 no 1365 0.408518752632452 1979 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1135 dihydrocapsaicin 536.708 nM 0.231106206472426 0.408031333614523 no 1366 0.408616146780753 1763 107982 A Capsaicinoid. SGTC_1982 st072467 71.9 µM 0.230871627032454 0.40812074721204 no 1367 0.408707266826257 1857 3163533 SGTC_3337 9144342 33.5465 µM 0.230498801972763 0.408262865118355 no 1368 0.408852097157506 1957 17682949 SGTC_1999 st074831 12.5 µM 0.229308362599714 0.408716731704602 no 1369 0.409314627111989 1881 17112523 SGTC_2917 7979103 53.79 µM 0.229065900733926 0.408809187677427 no 1370 0.409408848060231 1987 2980565 SGTC_3065 9113888 49.47 µM 0.22827428246339 0.409111084213947 no 1371 0.409716508199756 1963 16648368 SGTC_1103 duloxetine 36.1 µM 0.228071902699784 0.409188273698695 no 1372 0.409795171438122 1980 60835 A selective serotonin reuptake inhibitor. SGTC_1166 k206-0078 225 µM 0.226759034489212 0.409689098978236 no 1373 0.410305559834562 1867 5404595 SGTC_101 0490-5701 117.494 µM 0.225810539708838 0.410051016974266 no 1374 0.41067438964345 2014 4661669 SGTC_1771 st048882 4.1505 µM 0.22576888262803 0.410066913862644 no 1375 0.410690590147103 1818 4580403 SGTC_2983 9022671 12.99 µM 0.225569023933886 0.410143184616706 no 1376 0.410768317623352 2062 6405161 SGTC_2196 6573537 42.6665 µM 0.225228307326677 0.410273217882087 no 1377 0.410900834532146 2020 2903087 SGTC_1819 st053448 58.6 µM 0.22443057450549 0.410577708305388 no 1378 0.411211141191957 1929 2857616 SGTC_2621 lithochol-11-enic acid 100 µM 0.222826258452537 0.411190230341236 no 1379 0.411835365230525 2044 6708711 SGTC_296 1222-0039 74.9 µM 0.222399022655961 0.411353383992008 no 1380 0.412001636289712 1876 5984176 SGTC_1225 1216-0074 20.6 µM 0.222324819669273 0.411381722338746 no 1381 0.412030516120528 1879 4241466 SGTC_3182 9108849 49.47 µM 0.222021782593851 0.411497457919488 no 1382 0.412148463210571 1929 17133045 SGTC_1067 clotrimazole 1.36 µM 0.219612302523422 0.412417957110973 no 1383 0.413086554641268 1896 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2124 5246320 200 µM 0.219273124514064 0.412547572875751 no 1384 0.413218648005967 1924 579342 SGTC_2319 6033012 152.6 µM 0.218860289335306 0.412705349354112 no 1385 0.413379440516503 1869 847246 SGTC_1997 st073024 93.8 µM 0.21693305252166 0.413442082874059 no 1386 0.414130259353057 2034 686268 SGTC_1430 4049-0248 69.1 µM 0.215017643976371 0.414174596829333 no 1387 0.414876781186256 2026 22774488 SGTC_2881 9058953 51.95 µM 0.214547226436947 0.414354545436512 no 1388 0.415060171435691 1977 17122249 SGTC_63 0099-0242 26.702 µM 0.210050465441677 0.416075591462354 no 1389 0.416814142893208 2051 3898502 YLR359W ADE13 SGTC_2363 9053361 176 µM 0.209605830885589 0.41624585455152 no 1390 0.416987664175356 2033 6469797 YMR079W SEC14 SGTC_1713 st033146 12.748 µM 0.209444999033703 0.416307445468183 no 1391 0.41705043374756 2018 674619 SGTC_1172 0370-0043 85 µM 0.208552204740917 0.416649380363047 no 1392 0.417398912558064 1971 376585 SGTC_2736 butenafine 14.65 µM 0.207738861365168 0.416960940943476 no 1393 0.417716436281726 2015 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1956 st077085 54 µM 0.207387174665363 0.417095674762691 no 1394 0.417853749005599 1906 24208685 SGTC_711 k292-0785 179 µM 0.204352422020859 0.418258714221422 no 1395 0.419039053658485 1969 4146315 SGTC_275 trichlorophene 5.69 µM 0.20405042194978 0.418374492100845 no 1396 0.419157048346369 1955 62616 SGTC_3163 9099914 49.47 µM 0.203436429790119 0.418609900298917 no 1397 0.419396964120045 2064 16268368 SGTC_2936 9038235 15.59 µM 0.202735052496106 0.418878848135816 no 1398 0.419671062064169 1978 4749415 SGTC_44 0929-0055 61.211 µM 0.201537127120773 0.419338288291302 no 1399 0.420139300851783 1926 1379590 SGTC_2006 4011487 200 µM 0.201244686409547 0.419450464765462 no 1400 0.420253625736844 2020 45595294 SGTC_2937 9044753 11.33 µM 0.201084496117553 0.419511914465274 no 1401 0.42031625234905 1962 6465530 YGL099W LSG1 SGTC_597 k018-0003 82.8 µM 0.200853525574895 0.419600519235364 no 1402 0.420406554147303 2020 6786234 SGTC_57 miconazole 162.5 nM 0.199469143500812 0.42013168027812 no 1403 0.420947889127013 1904 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3292 9120825 59.784 µM 0.195600396902054 0.421616813182287 no 1404 0.422461474798971 2096 24824900 SGTC_1401 3807-4679 7.6 µM 0.195332413631043 0.421719728051171 no 1405 0.422566361681803 1964 3291456 SGTC_1072 oxiconazole 14.9 nM 0.194002564517206 0.422230515193637 no 1406 0.423086936930062 2010 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2470 5664817 21.68 µM 0.193489951189898 0.422427441908257 no 1407 0.42328763757376 2082 2859561 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.193295962477928 0.422501970118334 no 1408 0.423363594089792 1920 5282362 SGTC_2187 6125751 200 µM 0.19294230890917 0.422637846849821 no 1409 0.423502074902016 1988 874498 SGTC_2712 st079126 47.7 µM 0.192925090974522 0.422644462362975 no 1410 0.423508817203366 1964 3152970 SGTC_54 0159-0055 9 µM 0.192707546558178 0.4227280496413 no 1411 0.423594006469475 2092 3319099 SGTC_3103 9120822 49.47 µM 0.191975320764758 0.423009418930995 no 1412 0.423880768514109 2057 17141819 SGTC_905 2-aminofluorene 215 µM 0.191763636146802 0.423090769403372 no 1413 0.423963678211518 2044 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2675 theaflavin digallate 100 µM 0.191540240527005 0.423176623974247 no 1414 0.424051178361856 1996 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_870 0573-2213 57.6 µM 0.191485773099652 0.42319755724599 no 1415 0.424072512866759 2057 3916321 SGTC_178 4092-0806 87.505 µM 0.190664141194612 0.423513358371395 no 1416 0.424394367215705 2054 2169044 SGTC_1393 3470-5649 58.2 µM 0.190459516007805 0.423592015431666 no 1417 0.424474532015119 1975 4108395 SGTC_1032 k061-1018 98.7 µM 0.190399974678121 0.423614903440125 no 1418 0.424497858756719 2109 4005393 SGTC_467 ro 31-8220 72.8 µM 0.190143237358143 0.423713597601997 no 1419 0.424598444776845 2078 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1207 2099-0101 141 µM 0.189852159303511 0.42382549871059 no 1420 0.424712490946216 2078 5837381 SGTC_445 e6 berbamine 66 µM 0.189404999519113 0.423997415339575 no 1421 0.424887703170599 1976 6610268 A calcium/calmodulin antagonist. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.189213487273852 0.424071049239356 no 1422 0.424962748642438 1933 75037 A free radical scavenger. SGTC_1704 st028805 70.8 µM 0.189000775455532 0.424152837198782 no 1423 0.425046104509335 1965 2876101 SGTC_1625 st003711 30.1 µM 0.188704451582158 0.424266779541977 no 1424 0.425162231208753 2031 24207034 YER133W GLC7 SGTC_1153 4055-0057 267 µM 0.188568795073189 0.424318944244127 no 1425 0.425215395959656 1914 882706 SGTC_2514 salinomycin 42.74 µM 0.187892504006189 0.424579021723693 no 1426 0.425480459511512 2102 23682228 A polyether potassium ionophore. SGTC_1112 tnp00069 1.16933 µM 0.187259193097017 0.424822600341512 no 1427 0.425728708088437 2056 145826 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.187041002938229 0.424906525425193 no 1428 0.425814242250794 2053 66535 A nucleotide analog. SGTC_2013 4024628 200 µM 0.186641261874208 0.425060291427032 no 1429 0.42597095643344 2005 5230760 SGTC_227 fluconazole 33.516 µM 0.185725758729552 0.425412495462701 no 1430 0.426329913605088 1941 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1001 4048-4355 44.4 µM 0.185546393770295 0.425481506099783 no 1431 0.426400247490749 1962 21824233 SGTC_1137 ixabepilone 100 µM 0.185260821487192 0.425591384696498 no 1432 0.426512232990058 1904 154225 A novel microtubule stabilizer. SGTC_2458 5808907 16.39 µM 0.184295108087139 0.425963001452832 no 1433 0.426890975690548 2083 2731747 SGTC_2281 7943571 200 µM 0.183075390702202 0.426432455578212 no 1434 0.427369432397723 2136 1244024 SGTC_3312 9133330 71.43 µM 0.18249284559943 0.426656706805807 no 1435 0.427597984236077 2065 17617324 SGTC_1282 0886-0010 32.4 µM 0.180789655459824 0.427312487025716 no 1436 0.42826634153034 2093 2836211 YNL267W PIK1 SGTC_2057 5236571 38.335 µM 0.179902290374914 0.427654229401391 no 1437 0.428614638540371 2066 54684039 YBR257W POP4 SGTC_2405 ticlatone 3.52 µM 0.177977435448073 0.428395716512317 no 1438 0.429370348356424 2048 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2457 5731572 11.68 µM 0.176965648049069 0.428785575917447 no 1439 0.429767686275091 2102 2865357 SGTC_2558 carylophyllene oxide 100 µM 0.176293770108169 0.429044500675446 no 1440 0.430031578059077 2131 6708694 An oxygenated terpenoid and antifungal agent. SGTC_130 0136-0219 337.655 µM 0.17611388532524 0.429113828905959 no 1441 0.430102236255872 2128 234244 SGTC_1195 1502-0147 41.1 µM 0.175720178732878 0.429265572444656 no 1442 0.430256890818543 1990 817940 SGTC_2880 9042983 58.44 µM 0.173022344766425 0.430305659533254 no 1443 0.431316931960663 1993 6464714 SGTC_2012 4023501 200 µM 0.172681101457431 0.430437252560353 no 1444 0.431451049737021 1971 3477460 SGTC_1661 st013063 9.66 µM 0.171092960498716 0.431049785841185 no 1445 0.432075335484311 2009 721395 SGTC_2028 5153890 36.43 µM 0.170655709462268 0.431218459258502 no 1446 0.432247245284913 1998 2830968 YPR165W RHO1 SGTC_1633 st005664 67.9 µM 0.169349924450082 0.431722251816902 no 1447 0.432760704499411 2017 2063822 SGTC_968 1309-0633 340 µM 0.168510435477064 0.432046198681814 no 1448 0.433090867368919 2117 3761976 SGTC_2650 prasterone 100 µM 0.167827206565463 0.432309880748632 no 1449 0.433359609159207 2083 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_654 1124-0271 80.9 µM 0.167625465852759 0.432387745356431 no 1450 0.433438967906332 1943 5403748 SGTC_2984 9022109 38.96 µM 0.167005600237139 0.432627007448904 no 1451 0.433682821230232 2154 6459207 SGTC_2381 9035592 200 µM 0.165516310992275 0.433201959417166 no 1452 0.434268806289143 1938 4749657 SGTC_2994 9053520 71.4286 µM 0.164646781670895 0.433537713597485 no 1453 0.434611003610263 2089 4647384 SGTC_2434 5670830 169.91 µM 0.162114587459718 0.434515750359893 no 1454 0.435607809509025 2006 1549830 SGTC_2414 st077232 92.9 µM 0.161690371731284 0.434679639159617 no 1455 0.435774843506996 1876 729801 SGTC_482 fipronil 114 µM 0.161381212619817 0.434799084792264 no 1456 0.435896581437675 2129 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2657 nystatin 74.44 µM 0.160184672819984 0.435261431714016 no 1457 0.436367801402537 2085 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2557 derrustone 83.84 µM 0.159235599661576 0.43562821969361 no 1458 0.436741628600104 1930 629853 An antioxidant. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.158227441495247 0.436017902890567 no 1459 0.437138790467911 2101 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2704 st078022 71.1 µM 0.157447533386627 0.436319403269143 no 1460 0.437446077174403 2145 54697681 SGTC_3064 1327-0027 10 µM 0.157332460328897 0.436363891865381 no 1461 0.437491419587774 2057 16000455 YPR107C YTH1 SGTC_2824 7998404 51.95 µM 0.157056323403851 0.436470652927957 no 1462 0.437600229591175 2043 837851 SGTC_868 0527-0199 213 µM 0.156353927911146 0.436742236469289 no 1463 0.437877025328516 2014 2849450 SGTC_3268 9137683 49.47 µM 0.15619517804384 0.436803621766513 no 1464 0.437939588725835 2007 1953228 SGTC_2641 levomentholum 100 µM 0.155041154904007 0.437249904343926 no 1465 0.438394436319788 2097 16666 SGTC_3291 9121177 71.43 µM 0.154532383813469 0.437446681145255 no 1466 0.43859498964565 2006 17015612 SGTC_3037 9091026 49.47 µM 0.154048075982215 0.437634010696331 no 1467 0.438785914408616 2115 25236398 YIL048W NEO1 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.153261672455648 0.437938220176053 no 1468 0.439095962241349 2052 65057 A dermal irritant. YDR527W RBA50 SGTC_301 4119-0100 24.5 µM 0.152316980461585 0.438303709876389 no 1469 0.439468466355887 2023 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_341 1486-1430 230 µM 0.150871183986485 0.438863172534232 no 1470 0.440038666050758 2051 2054753 YPL210C SRP72 SGTC_1930 st074634 34.3 µM 0.150185123885755 0.439128691856291 no 1471 0.440309281097513 2085 684253 YOR116C RPO31 SGTC_1408 3909-7976 48.8 µM 0.149317173641843 0.439464645625062 no 1472 0.440651682288691 2057 24152374 SGTC_2224 6650123 117.647 µM 0.145997503382085 0.440749976359265 no 1473 0.441961679661169 2058 2908370 SGTC_3346 9158254 43.5805 µM 0.143086446942325 0.441877611822376 no 1474 0.443110954286529 2056 17639500 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.141928161938348 0.442326420092975 no 1475 0.443568374737252 2119 5282309 SGTC_988 1497-1057 103 µM 0.140906018529597 0.442722538201443 no 1476 0.443972093744768 2189 3533044 SGTC_244 nsc-207895 1.295 µM 0.139221078098704 0.443375639314198 no 1477 0.444637726394653 2111 42640 SGTC_912 3474-0017 2.18 µM 0.138622202732774 0.443607807026887 no 1478 0.444874348729739 2112 3360550 SGTC_966 1300-0360 30.2 µM 0.138492647635076 0.443658034568818 no 1479 0.444925539980895 2043 70588 SGTC_2734 clemastine 41.6 µM 0.13757736942949 0.444012906819887 no 1480 0.445287221003243 2174 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1033 k072-0102 21.3 µM 0.136697879127309 0.444353945662486 no 1481 0.445634803003378 2180 5965931 SGTC_1785 bathophenanthroline 24 µM 0.135125023824859 0.444963952346904 no 1482 0.446256512735285 1996 72812 An iron chelator. SGTC_2330 7979373 200 µM 0.134681271023809 0.445136078387175 no 1483 0.446431940907174 1988 1863007 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.134465912024675 0.445219617120833 no 1484 0.446517082259018 2060 4213774 SGTC_2808 7946468 45.46 µM 0.133205577724799 0.4457085551764 no 1485 0.447015399886853 2093 2970879 SGTC_3142 9086498 49.47 µM 0.132717002795779 0.445898116724389 no 1486 0.447208597767176 2189 25236367 SGTC_1036 k216-0215 33.5 µM 0.131259012539076 0.446463873810218 no 1487 0.447785207227748 2147 622330 SGTC_2973 9094665 17.96 µM 0.13109115051705 0.44652901784041 no 1488 0.447851600807354 2163 25237061 YIL048W NEO1 SGTC_3122 9126309 49.47 µM 0.130003342068186 0.446951210328991 no 1489 0.448281891272276 2206 17591206 SGTC_596 1155-0152 116 µM 0.129701037247657 0.447068549425851 no 1490 0.448401480948107 2100 280313 SGTC_2461 5755302 26.15 µM 0.126380706530026 0.448357632802671 no 1491 0.449715286824441 2186 2788904 SGTC_3096 9117468 49.47 µM 0.12493669502139 0.448918426042564 no 1492 0.450286833765321 2192 41316311 SGTC_3076 9116187 49.47 µM 0.124681950460259 0.44901736872206 no 1493 0.450387673664515 2168 27241210 SGTC_1828 st055811 49 µM 0.123931414804945 0.449308894860562 no 1494 0.450684789632357 2192 5877589 SGTC_3174 9107204 49.47 µM 0.12390674911412 0.449318476074694 no 1495 0.450694554555952 2153 3938802 SGTC_1842 st055362 61.2 µM 0.123573480194503 0.449447934937455 no 1496 0.450826495626115 2075 676032 SGTC_1190 1486-1332 13 µM 0.123541350720965 0.449460415969178 no 1497 0.450839215962932 2173 4150046 SGTC_36 0335-0881 14.2 µM 0.123195543655393 0.449594751521408 no 1498 0.450976127168422 2113 23828853 SGTC_1498 4478-3555 97.6 µM 0.12273279507567 0.449774524338593 no 1499 0.451159346734225 2203 3437919 SGTC_594 1487-1584 10.8 µM 0.122634052060105 0.449812886267672 no 1500 0.451198444156096 2089 5013332 SGTC_2854 9024559 71.43 µM 0.121236707302319 0.450355808605995 no 1501 0.45175177515921 2079 3163529 SGTC_2752 diclazuril 33.15 µM 0.121204729107334 0.450368234459633 no 1502 0.451764439224769 2183 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2041 5107442 45.335 µM 0.120293775605779 0.450722226510114 no 1503 0.45212521732791 2179 793005 SGTC_2332 7982454 138.89 µM 0.116952714665246 0.452020879791033 no 1504 0.45344876223743 2186 2981748 SGTC_1113 artemisinin 1.17947 µM 0.1154780352291 0.45259424431815 no 1505 0.454033114671877 2224 2240 An anti-malaria and mitochondrial poison. SGTC_1316 1272-0050 65.9 µM 0.114827851109555 0.45284707141844 no 1506 0.454290786536494 2174 7340392 SGTC_2318 6029776 164 µM 0.114567529112146 0.452948304195609 no 1507 0.454393959104136 2143 818325 SGTC_2594 a-mangostin 100 µM 0.114442767731651 0.452996821890835 no 1508 0.454443406466072 2181 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_918 glabranin 770.725 nM 0.113947690006592 0.453189356569218 no 1509 0.454639630287178 2119 124049 Also referred to as licorice root. SGTC_70 0141-0289 43.283 µM 0.11391264274977 0.453202986790757 no 1510 0.45465352167089 2091 352408 SGTC_2234 tolnaftate 200 µM 0.113791681318015 0.453250030300047 no 1511 0.454701466552809 2209 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2832 7992762 51.95 µM 0.113238788276453 0.453465066099087 no 1512 0.45492062241318 1946 2985177 SGTC_141 0443-0274 32.331 µM 0.112137845120054 0.453893294719887 no 1513 0.455357055293204 2210 1627241 SGTC_2927 9011802 47.9 µM 0.11014386057047 0.454669021534961 no 1514 0.456147642018956 2082 43912568 SGTC_850 0388-0143 75.9 µM 0.109711030262841 0.454837429972858 no 1515 0.456319276171158 2094 67273 SGTC_943 3253-1379 105 µM 0.107210024694938 0.455810695559093 no 1516 0.457311181356446 2172 668464 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.106888641100733 0.45593578124502 no 1517 0.457438662325345 2170 364106 SGTC_2191 5911152 200 µM 0.10628175075231 0.456172000895676 no 1518 0.457679405182059 2213 2875902 SGTC_2478 5763493 32.33 µM 0.104276400725476 0.456952652077391 no 1519 0.45847500264704 2159 1365576 YLR208W SEC13 SGTC_750 4073-0104 132 µM 0.103445785972199 0.457276046153741 no 1520 0.458804587541884 2223 22330957 SGTC_1087 pterostilbene 9.05 µM 0.100768424061208 0.458318649901691 no 1521 0.459867146583587 2217 5281727 Similar to reservatol, lowers cholesterol. SGTC_531 3788-1495 174 µM 0.099400481085569 0.458851458001177 no 1522 0.460410150402893 2092 2896655 SGTC_582 0987-0078 156 µM 0.0989070299605375 0.459043673356169 no 1523 0.460606043588577 2233 1625765 SGTC_841 0251-0215 91.2 µM 0.0983995808523787 0.459241351369829 no 1524 0.460807503748681 2161 3888614 SGTC_2883 9059145 45.46 µM 0.0976778844764805 0.459522507265802 no 1525 0.461094038598095 2192 16476510 SGTC_1251 0490-5699 265 µM 0.0975754654285632 0.45956240895621 no 1526 0.461134703635549 2233 3883818 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0971145701526205 0.459741975322694 no 1527 0.461317705123158 2178 688664 SGTC_515 4092-1064 102 µM 0.0954026437178067 0.460409019294743 no 1528 0.461997508137607 2241 717353 SGTC_413 propylparaben 100 µM 0.0940558964369809 0.460933851357598 no 1529 0.462532377276668 2112 7175 A pharmaceutical preservative. SGTC_3221 9128209 49.47 µM 0.0938742460010445 0.461004646388138 no 1530 0.462604526094965 2161 16460723 SGTC_2546 rhodinyl acetate 100 µM 0.0936026350610377 0.461110504231926 no 1531 0.462712408165481 2253 6708682 SGTC_300 r073-0011 5.04 µM 0.0934074994839869 0.461186558214063 no 1532 0.462789916420753 2261 2735780 SGTC_134 0269-0018 6.916 µM 0.0922061610223315 0.461654810375846 no 1533 0.463267121556404 2139 4378915 SGTC_1562 morin hydrate 59.1 µM 0.0921089038269216 0.46169272117135 no 1534 0.463305757148613 2160 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_986 1493-0483 84 µM 0.0918445349272397 0.46179577376535 no 1535 0.463410779907765 2245 40079 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0895800530383099 0.462678586854585 no 1536 0.464310468018731 2160 279621 SGTC_1330 1469-0054 61.8 µM 0.0876812138700106 0.463418995261392 no 1537 0.465065025634044 2267 7102664 SGTC_2051 5263410 176 µM 0.0863516642877871 0.463937497951346 no 1538 0.465593434825426 2281 227584 SGTC_1990 st072050 59.8 µM 0.085962319171249 0.464089347842688 no 1539 0.465748185626211 2232 17233948 SGTC_1710 st031758 61.5 µM 0.0851451808574692 0.464408059884097 no 1540 0.466072985783435 2248 5394341 SGTC_443 clozapine 122 µM 0.0835326480488299 0.465037069940798 no 1541 0.466714009354055 2266 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3257 9139206 32.98 µM 0.082999820398316 0.46524493240572 no 1542 0.466925841211909 2245 4910041 SGTC_1550 gossypolone 36.6 µM 0.0829929575957397 0.465247609729399 no 1543 0.466928569660494 2255 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2959 9079155 11 µM 0.0815646128653168 0.465804871116059 no 1544 0.467496471169892 2190 16189457 SGTC_2524 avocatin b 10.57 µM 0.0813436191678746 0.465891096693679 no 1545 0.467584342910747 2234 6710748 SGTC_852 0418-0143 439 µM 0.0809488338908884 0.466045134881428 no 1546 0.467741321766545 2262 5369229 SGTC_922 1866-0035 480 µM 0.0808118127766261 0.466098599271523 no 1547 0.467795806780215 2112 3156169 SGTC_3027 9089541 49.47 µM 0.0799268448115448 0.466443920401156 no 1548 0.468147719527054 2189 9943819 SGTC_2611 pyromycin 23.93 µM 0.0790815797930705 0.466773772735392 no 1549 0.468483867408619 2189 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2117 5521686 200 µM 0.0776905173295269 0.467316664132454 no 1550 0.469037118690964 2211 803312 SGTC_1653 st012112 65 µM 0.0769645638280581 0.467600006971115 no 1551 0.46932586764398 2249 720429 SGTC_1697 st025554 27.742 µM 0.0766182957087246 0.467735162729826 no 1552 0.469463601932876 2259 1269519 SGTC_1820 st053765 18.6 µM 0.0756477198036078 0.468114018774668 no 1553 0.469849685145227 2181 3690829 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0744285269211531 0.468589961225217 no 1554 0.470334705273788 2244 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_112 phenothiazine 287.218 µM 0.0738643250913486 0.468810226764143 no 1555 0.470559171363811 2281 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_799 1310-0557 151 µM 0.0735422390840938 0.468935974079883 no 1556 0.470687316562883 2183 5354492 SGTC_949 1165-0505 146 µM 0.0727538508701184 0.469243785977579 no 1557 0.471000997626473 2198 6244267 SGTC_2249 haloperidol 116.36 µM 0.0727269355294723 0.469254294910366 no 1558 0.471011706924008 2232 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1776 st049249 45.9 µM 0.0714292989648983 0.46976097457168 no 1559 0.471528045978005 2213 1822314 SGTC_3216 9129716 49.47 µM 0.0697991581118852 0.470397554307094 no 1560 0.472176758637333 2237 8056934 SGTC_2452 5863136 48.41 µM 0.0696297414840705 0.470463716879623 no 1561 0.472244182051437 2267 2184096 SGTC_3033 9090887 49.47 µM 0.0689805358190522 0.470717259838505 no 1562 0.472502556377583 2242 19325384 SGTC_3296 9122258 64.045 µM 0.0681970557535702 0.471023258570364 no 1563 0.472814385342599 2230 4730474 SGTC_964 1287-0107 19.4 µM 0.0681609725934291 0.471037351749884 no 1564 0.472828747022711 2262 51516812 YPR165W RHO1 SGTC_2867 9039098 71.43 µM 0.0671811539256654 0.471420058212143 no 1565 0.473218744106731 2303 6463460 SGTC_2370 9071495 200 µM 0.0670164431936994 0.471484395024663 no 1566 0.473284306426492 2141 21791103 SGTC_165 k038-0023 64.381 µM 0.0660897387299039 0.471846384116154 no 1567 0.473653190149163 2281 46368543 SGTC_1289 0976-0073 69.1 µM 0.0644886253801482 0.472471865292806 no 1568 0.47429058194565 2249 3391136 SGTC_1511 0906-3109 28.5 µM 0.0630594807323692 0.473030223616501 no 1569 0.474859569870959 2296 2882180 SGTC_1096 rimcazole 32.2 µM 0.0622048023555589 0.473364166774935 no 1570 0.475199869085918 2259 18528119 A dopamine reuptake inhibitor. SGTC_2071 5230951 39.92 µM 0.0615975419198357 0.473601449251788 no 1571 0.475441667245514 2280 1799272 SGTC_3327 9140648 26.9345 µM 0.0611054778705655 0.473793726475278 no 1572 0.475637603297835 2283 8029710 SGTC_3198 9112019 49.47 µM 0.060818086914868 0.473906029185058 no 1573 0.475752042854894 2273 45595555 SGTC_1127 asiatic acid 681.4 nM 0.060293713332537 0.474110942064152 no 1574 0.475960854436209 2256 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_673 1082-0474 110 µM 0.0600756144238241 0.474196172014842 no 1575 0.47604770587314 2273 3098046 SGTC_1308 1187-1617 41.4 µM 0.0600408260054729 0.474209766943127 no 1576 0.476061559436713 2282 2882570 SGTC_2786 7743617 45.45 µM 0.0595995428284445 0.474382218118737 no 1577 0.47623729124664 2221 583674 SGTC_1905 st060207 84.5 µM 0.0578679987598212 0.475058942623672 no 1578 0.476926886839888 2165 1948547 SGTC_1862 st057513 3.81 µM 0.0566384672177009 0.475539513687171 no 1579 0.47741659565198 2287 5393163 SGTC_2575 plumbagin 510 nM 0.056354784742748 0.47565039805852 no 1580 0.477529588112545 2283 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1850 st056238 17 µM 0.0562341723183951 0.475697543004904 no 1581 0.477577629324849 2301 5393177 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0556833060823348 0.475912869741101 no 1582 0.477797049341627 2281 4620898 SGTC_1300 1094-0077 113 µM 0.0556535012844008 0.475924520265775 no 1583 0.477808921325953 2269 5532636 SGTC_3256 9138902 49.47 µM 0.0532979397330883 0.476845360052129 no 1584 0.478747260862636 2315 17228773 SGTC_2100 5377183 190 µM 0.0528406272438306 0.47702414784863 no 1585 0.47892944542002 2283 2844202 SGTC_2988 9073640 71.4286 µM 0.0520675549019832 0.477326393479103 no 1586 0.479237432660828 2284 9102229 SGTC_2656 pseudo-anisatin 100 µM 0.0514447471241395 0.477569900146437 no 1587 0.479485564454098 2295 6708809 A neurotoxin. SGTC_469 w7 172 µM 0.0502036052994206 0.478055189216636 no 1588 0.479980069282694 2314 45115570 A P450 inhibitor. SGTC_1675 st018485 24.5 µM 0.049652414109244 0.478270716611147 no 1589 0.480199688845102 2192 3323024 SGTC_362 0310-0100 9.03 µM 0.0483619813788748 0.47877532780244 no 1590 0.480713879147914 2278 790235 SGTC_20 0481-0013 4.944 µM 0.0481223018165773 0.478869055939129 no 1591 0.480809386257097 2301 182045 SGTC_2063 5246145 200 µM 0.0479919037570773 0.478920049376985 no 1592 0.480861347519739 2287 711240 SGTC_1394 3474-0001 65.7 µM 0.0472004398735338 0.479229566450545 no 1593 0.481176738473037 2268 5017666 YIL048W NEO1 SGTC_2890 9046729 58.44 µM 0.0470743090614721 0.479278893476428 no 1594 0.481227001515234 2255 903329 SGTC_658 3253-0951 102 µM 0.0464334765691288 0.479529514056318 no 1595 0.481482377417657 2278 1184878 SGTC_3193 9111931 49.47 µM 0.045932548021344 0.479725425810797 no 1596 0.481682005988229 2308 17087244 SGTC_2132 5317594 122.667 µM 0.0442585351623745 0.480380162825328 no 1597 0.482349161706228 2297 794577 SGTC_962 1254-0300 21.5 µM 0.0435816073385971 0.480644936795367 no 1598 0.482618956491858 2299 7340576 SGTC_2718 lomofungin 53.02 µM 0.0432685825306362 0.480767376407871 no 1599 0.482743717633118 2304 5351222 A RNA synthesis inhibitor. SGTC_484 loperamide 105 µM 0.0417667197355987 0.481354854876537 no 1600 0.483342332827101 2329 3955 An opioid-receptor agonist. SGTC_876 0720-0963 56.8 µM 0.040105083620435 0.482004878454071 no 1601 0.484004674460541 2334 765861 SGTC_1383 3049-0032 20.7 µM 0.0394689064666698 0.482253760472502 no 1602 0.484258271618492 2323 712864 SGTC_561 1550-0330 72.9 µM 0.0388510627226077 0.482495476807687 no 1603 0.484504566687063 2305 6812934 SGTC_481 bay k-8644 50 µM 0.038023695199987 0.48281917428617 no 1604 0.484834394824511 2309 2303 A calcium channel antagonist. SGTC_645 0845-0943 5.41 µM 0.03786651366201 0.482880670937497 no 1605 0.48489705605861 2306 1885106 SGTC_2269 7935389 174.42 µM 0.0375899275618922 0.482988885136686 no 1606 0.485007319444356 2338 97605 SGTC_866 0495-0101 262 µM 0.0371392055352435 0.483165232627763 no 1607 0.485187006040984 2309 635694 SGTC_2385 9074692 200 µM 0.0369370563588164 0.483244325685318 no 1608 0.485267596597314 2305 17046906 SGTC_731 3966-0296 387 µM 0.0365778715942179 0.483384862244452 no 1609 0.485410793815257 2342 660956 SGTC_24 0417-1663 219 µM 0.0361254869970293 0.483561867605481 no 1610 0.485591149951844 2293 4329390 SGTC_583 1488-1091 88.9 µM 0.0355580528996913 0.483783893174146 no 1611 0.485817378044926 2358 4303273 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0351997803220281 0.483924080633995 no 1612 0.485960218700801 2332 641818 YHR062C RPP1 SGTC_91 0417-1751 58.384 µM 0.0347008127430619 0.484119323548793 no 1613 0.486159156421902 2340 6795624 SGTC_2036 5160441 105 µM 0.0340938745959889 0.484356819804595 no 1614 0.486401146505711 2315 134534 YIL048W NEO1 SGTC_2863 9028737 58.44 µM 0.0316414027578005 0.485316533176032 no 1615 0.487379012640424 2359 6460917 SGTC_2299 7976368 114.88 µM 0.0316176445512471 0.485325830779522 no 1616 0.487388486053611 2328 2979718 SGTC_347 4534-1311 26.2 µM 0.0315873611680391 0.485337681975593 no 1617 0.487400561344153 2352 2862016 SGTC_2787 5284540 71.43 µM 0.0310626788761988 0.485543014869269 no 1618 0.487609776619599 2309 736958 SGTC_1921 5740136 50 µM 0.0303874492887905 0.485807269643726 no 1619 0.487879027125664 2342 1774243 SGTC_614 0462-0418 107 µM 0.0301397120504206 0.485904224529421 no 1620 0.487977814734856 2327 5188303 SGTC_1610 st001799 48.1 µM 0.0297369912497281 0.486061835833049 no 1621 0.488138405103269 2340 621897 SGTC_1240 0356-0016 42.1 µM 0.0269421801880963 0.487155689021545 no 1622 0.489252925395509 2331 4305613 SGTC_2585 alliin 100 µM 0.0267612321581585 0.487226513177965 no 1623 0.48932508719558 2336 87310 A garlic compound which reacts with lipids. SGTC_1780 st038448 24.544 µM 0.0254582956171995 0.48773650220082 no 1624 0.489844706486145 2336 728868 YDL195W SEC31 SGTC_1896 st058441 89 µM 0.0251444375164857 0.487859354026155 no 1625 0.489969877680897 2292 688759 SGTC_3202 9113761 49.47 µM 0.023940124553737 0.488330762502769 no 1626 0.490450184339764 2343 4798415 SGTC_1130 3454-2858 15.9 µM 0.0230003894916828 0.488698617675009 no 1627 0.490824981131427 2278 715628 YIL048W NEO1 SGTC_2358 9037157 4 µM 0.0222635912664333 0.488987040851491 no 1628 0.491118845819546 2344 2388925 SGTC_405 ebelactone b 50 µM 0.0221693024299697 0.489023951084695 no 1629 0.491156452341087 2330 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1917 st066507 28.5 µM 0.0217852192135778 0.489174304964236 no 1630 0.491309642374497 2310 3156428 SGTC_1082 camptothecin 424.86 nM 0.0213230061443243 0.48935524572876 no 1631 0.491493995880307 2376 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1432 4049-0298 68.4 µM 0.0208332292371137 0.489546979192282 no 1632 0.4916893451942 2375 741646 SGTC_529 4076-0302 30.3 µM 0.0207361178272645 0.489584995782935 no 1633 0.491728078674096 2334 5816522 SGTC_3140 9094243 49.47 µM 0.0206182262816333 0.489631147383287 no 1634 0.491775100543056 2378 19291112 SGTC_1118 chelidonine 707.474 nM 0.0203907830599931 0.489720186124739 no 1635 0.491865818187935 2365 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2136 5328288 199.296 µM 0.0189770654987204 0.490273635047602 no 1636 0.492429700598085 2348 262395 SGTC_447 ml7 120 µM 0.0184638410216268 0.490474559313623 no 1637 0.492634411664898 2373 4216 Selective myosin light chain kinase inhibitor. SGTC_424 splitomicin 100 mM 0.0180261200482305 0.490645926328337 no 1638 0.492809008004638 2253 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1683 st010134 710 nM 0.0170677527171257 0.491021131489183 no 1639 0.493191282383833 2375 3818134 SGTC_552 k242-0005 476 µM 0.0169869401769093 0.491052770333396 no 1640 0.493223517249629 2357 4088318 SGTC_1737 st035557 69.7 µM 0.0167428280609644 0.491148342787207 no 1641 0.493320890045016 2375 5716916 SGTC_269 exalamide 29 µM 0.0164250940053485 0.491272739762951 no 1642 0.493447630163467 2359 3316 A derivative of salicylamide. SGTC_1192 1488-0095 21.4 µM 0.0158867766242165 0.491483499883058 no 1643 0.493662359698921 2358 915875 SGTC_435 c-PAF 6.7 µM 0.0152070949059804 0.491749609858132 no 1644 0.493933480700392 2379 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2567 aureobasidin a 60 nM 0.0145463154927214 0.492008322696587 no 1645 0.494197064372262 2341 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2302 7771753 200 µM 0.0138451607306849 0.492282847239298 no 1646 0.494476756463162 2362 2203047 SGTC_2583 asiatic acid 100 µM 0.013421325240443 0.492448794187265 no 1647 0.494645826646018 2378 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1286 0929-0070 131 µM 0.0122685272902605 0.492900162873366 no 1648 0.495105688525283 2359 1420408 SGTC_2815 7968870 71.43 µM 0.0113115648647562 0.493274860678528 no 1649 0.495487434749733 2379 2977326 YHR190W ERG9 SGTC_2056 5235370 200 µM 0.0111353710183035 0.493343849882454 no 1650 0.49555772149752 2379 5511916 SGTC_638 3970-0837 4.09 µM 0.0104658718422489 0.493605995995405 no 1651 0.495824797442439 2381 4118451 YLR208W SEC13 SGTC_1692 fluoroquinolonic acid 71 µM 0.0100360061445844 0.493774313754561 no 1652 0.495996280032729 2359 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1149 3909-7961 23.3 µM 0.00963774944508368 0.493930255717543 no 1653 0.496155153780734 2369 735261 SGTC_460 trequinsin 123 µM 0.00948773666041188 0.493988995179891 no 1654 0.496214997486787 2389 5537 A vasodilator. SGTC_1131 3454-3128 32.3 µM 0.00872925766907615 0.4942859894903 no 1655 0.496517574266115 2369 710982 SGTC_2348 9022543 33.42 µM 0.00859196091930452 0.49433975052312 no 1656 0.496572345690382 2369 3162678 YDL140C RPO21 SGTC_339 3091-4833 71.4 µM 0.00854035657968493 0.494359957164991 no 1657 0.496592932087987 2388 3240077 SGTC_1479 0549-0158 134 µM 0.00837164112271994 0.494426020950324 no 1658 0.496660237410708 2394 5440202 SGTC_636 0kpi-0074 126 µM 0.00610423577597357 0.495313881270338 no 1659 0.497564777382855 2388 616434 SGTC_160 3453-0671 289.699 µM 0.00569604842274276 0.495473720019339 no 1660 0.497727617740855 2392 5322268 SGTC_1893 st059353 36.1 µM 0.00558761997873973 0.495516178750602 no 1661 0.497770873743114 2386 3112488 SGTC_2151 5563267 85.4165 µM 0.00468320450332389 0.495870334374218 no 1662 0.498131678545324 2387 5310824 SGTC_2580 diallyl disulphide 81.36 µM 0.00393239106715822 0.496164344212602 no 1663 0.498431206983463 2390 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1508 1080-0625 72.9 µM 0.00341467363736034 0.496367077580094 no 1664 0.4986377449596 2383 767111 SGTC_500 h-89 112 µM 0.00296483676160743 0.496543230312725 no 1665 0.498817202994155 2399 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_802 4112-3352 742 µM 0.00242850362683367 0.496753255206916 no 1666 0.49903116817745 2396 704594 SGTC_701 4424-0219 185 µM 0.00125285693291889 0.497213634589785 no 1667 0.499500182528921 2402 2911779 SGTC_1628 st004252 77.7 µM 0 0.497704253318168 no 1668 0.5 2406 692968 SGTC_1213 1315-0166 115 µM -0.000860133611734497 0.498041083663634 no 1669 0.499656856377796 2410 768401 SGTC_334 1502-1024 68.5 µM -0.00253492549849815 0.498696939894984 no 1670 0.498988712124045 2417 3296216 SGTC_1323 1348-1351 11.2 µM -0.00362002915060921 0.499121873483624 no 1671 0.498555820469772 2408 6989654 SGTC_2466 5983409 37.09 µM -0.00383760007930596 0.499207075797915 no 1672 0.498469022830922 2418 2879657 SGTC_2622 2-methoxyxanthone 59.94 µM -0.00410462865897547 0.499311646127113 no 1673 0.498362494680697 2421 71034 A hepatoprotective. SGTC_3085 9117376 49.47 µM -0.00448215874681207 0.499459489727651 no 1674 0.498211883355563 2422 16480349 SGTC_2606 farnesol 9.78 µM -0.00471895378961352 0.49955222047318 no 1675 0.498117416801124 2416 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_127 0180-0333 59.125 µM -0.00512957011324955 0.499713021013001 no 1676 0.497953606575829 2415 771601 SGTC_1398 3558-0053 112 µM -0.00548609822908104 0.499852640229522 no 1677 0.4978113744406 2418 4532369 SGTC_205 1486-1330 71.903 µM -0.00579026588337548 0.499971754692086 no 1678 0.497690031032153 2409 4118834 SGTC_1003 4049-0218 100 µM -0.00593451887558778 0.499971754692086 no 1679 0.497632483403432 2427 295161 SGTC_310 1273-0058 1.06 µM -0.006887740696256 0.499598465534517 no 1680 0.497252210746138 2421 2734232 SGTC_114 0364-0001 490.298 µM -0.00746199798111843 0.499373582016724 no 1681 0.497023121135225 2421 4003655 SGTC_725 1497-0963 19 µM -0.00751305994191254 0.499353585773331 no 1682 0.497002750931162 2419 3549977 SGTC_1344 1488-0097 29.1 µM -0.0079303045839001 0.499190189735482 no 1683 0.496836299365769 2429 747966 SGTC_172 1112-0046 2.638 µM -0.0099250897233192 0.498409019714562 no 1684 0.496040527078931 2424 2802135 YIL048W NEO1 SGTC_185 k048-0037 25.491 µM -0.0105535203361034 0.498162923577584 no 1685 0.495789832683485 2420 6827589 SGTC_1876 myriocin 605 nM -0.0125203608587645 0.497392705297799 no 1686 0.495005229184139 2434 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3255 9139072 49.47 µM -0.0135888995145688 0.496974267532768 no 1687 0.494578980279307 2455 17646060 SGTC_2975 9084847 53.72 µM -0.0136222370776324 0.496961212655772 no 1688 0.494565681746789 2468 27211724 SGTC_1940 st075990 51.1 µM -0.0149123414143098 0.496456014793356 no 1689 0.494051056996469 2557 1084979 SGTC_3170 9103054 49.47 µM -0.0159808717596703 0.496037588372391 no 1690 0.493624825935987 2445 16432970 SGTC_728 3030-5151 22.5 µM -0.0160842901251675 0.495997090938359 no 1691 0.493583573279646 2438 3125388 SGTC_2352 9027995 87.8 µM -0.0179700553937669 0.495258654756402 no 1692 0.492831370943417 2443 2997347 SGTC_3067 9117431 49.47 µM -0.018424016354631 0.495080893075532 no 1693 0.49265029670626 2455 17150885 SGTC_3219 9131112 49.47 µM -0.0186674201089428 0.494985581622262 no 1694 0.492553209355422 2441 17612988 YMR079W SEC14 SGTC_972 1319-0219 195 µM -0.0187224236440008 0.494964043510525 no 1695 0.492531269953965 2451 23903702 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0190666126727819 0.494829267386041 no 1696 0.49239398290673 2446 6857784 SGTC_421 streptovitacin 30 mM -0.0190766922225177 0.494825320486226 no 1697 0.49238996247941 2548 91467 include heat shock SGTC_1948 st076329 66.6 µM -0.0194721774282805 0.494670458765517 no 1698 0.492232216015016 2432 24208413 SGTC_3229 9132204 49.47 µM -0.0198542082483171 0.494520866194731 no 1699 0.492079837230216 2438 17682924 SGTC_3051 9093778 49.47 µM -0.0215871955649899 0.493842286878096 no 1700 0.491388623805974 2442 17217378 SGTC_3118 9124250 49.47 µM -0.0216216659130508 0.493828789627957 no 1701 0.491374875335646 2499 1504786 SGTC_2110 5483698 200 µM -0.0224588714431588 0.493500974649638 no 1702 0.491040959775556 2462 2848765 YHR062C RPP1 SGTC_1728 st035614 33.7865 µM -0.0243271022015077 0.492769469086328 no 1703 0.490295847547294 2549 15945546 SGTC_1216 1165-0504 9.65 µM -0.0251348727160794 0.492453194008672 no 1704 0.489973692278575 2457 6304004 SGTC_2907 7721985 69.9 µM -0.025288508620376 0.492393039821524 no 1705 0.48991241989698 2475 3267881 SGTC_1384 3089-0840 101 µM -0.0266975498735864 0.49184135585615 no 1706 0.489350483677394 2438 1069836 SGTC_1563 conessine 56.1 µM -0.0269474344057165 0.491743519801889 no 1707 0.489250830026731 2465 441082 An anti-amoebic, histamine inhibitor. SGTC_786 4544-0069 423 µM -0.0270744952131191 0.491693772502875 no 1708 0.489200158586626 2546 748821 YLR208W SEC13 SGTC_3247 9135149 49.47 µM -0.0275079133945737 0.491524080052338 no 1709 0.489027314130414 2453 8934436 YOR116C RPO31 SGTC_3270 9137563 49.47 µM -0.0279706902964978 0.491342894731471 no 1710 0.488842763875987 2562 17015724 SGTC_1527 coumarin 137 µM -0.0281261372154277 0.491282034919404 no 1711 0.488780773916696 2567 323 A hepatotoxic, DNA x-linker. SGTC_1705 st027868 56.3335 µM -0.02821144438851 0.491248635961327 no 1712 0.488746754777987 2520 292948 SGTC_1669 st015249 58.4 µM -0.0288481265011713 0.490999367913252 no 1713 0.488492858718565 2459 722793 SGTC_2409 alverine citrate 63.97 µM -0.02931250239022 0.490817561857695 no 1714 0.4883076778611 2682 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1348 1493-0373 93.8 µM -0.029704840263754 0.49066396061951 no 1715 0.488151225827196 2480 3010129 SGTC_1458 k015-0034 6.33 µM -0.0305410481291209 0.490336587841294 no 1716 0.487817778482219 2477 3598957 SGTC_152 4469-0003 551.229 µM -0.0305766688732809 0.490322642573748 no 1717 0.487803574495016 2461 697280 SGTC_1530 rhein 70.4 µM -0.0321015976705813 0.489725655130272 no 1718 0.48719551465572 2451 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1275 0867-0008 21.1 µM -0.0323045197226983 0.489646215804511 no 1719 0.487114602435005 2474 3422836 SGTC_1437 4092-1038 11.6 µM -0.0325300370932444 0.489557931412213 no 1720 0.487024681281703 2463 3977136 SGTC_789 1309-1135 70.6 µM -0.0336424258272902 0.489122466701313 no 1721 0.486581145241924 2474 3092424 SGTC_1097 itavastatin 7.23 µM -0.0339818862128064 0.488989581345366 no 1722 0.486445797533326 2482 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3072 9116419 49.47 µM -0.0343163590019756 0.488858649632085 no 1723 0.486312439977673 2480 17170162 SGTC_1932 st074806 40.9 µM -0.0347383093930223 0.488693475914103 no 1724 0.486144206436291 2629 17251235 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0350252014831728 0.488581172269826 no 1725 0.486029822660659 2509 7104 SGTC_2952 9073731 13.78 µM -0.0350690565551916 0.488564005321858 no 1726 0.486012337759883 2471 16457353 SGTC_2761 levamisole 97.89 µM -0.036921982883029 0.487838702138205 no 1727 0.485273605944978 2483 26879 An alkaline phosphatase inhibitor. SGTC_411 enrofloxacin 100 µM -0.0371170731952261 0.487762338948189 no 1728 0.485195829483532 2476 71188 A bacterial gyrase inhibitor. SGTC_2052 5265182 7.135 µM -0.037789140748828 0.487499278480544 no 1729 0.484927901308212 2489 1239884 SGTC_3259 9138485 49.47 µM -0.0383178166919954 0.487292348127595 no 1730 0.484717142775823 2478 17646153 SGTC_2171 5739187 198.077 µM -0.0383488515128331 0.487280200817708 no 1731 0.484704770766957 2468 2262761 SGTC_769 0302-0231 76 µM -0.0388943504120282 0.487066689546037 no 1732 0.484487310440308 2500 571869 YER009W NTF2 SGTC_525 k781-2675 26.7 µM -0.0394347009378166 0.486855197030598 no 1733 0.484271907034658 2475 3651118 YDL195W SEC31 SGTC_2964 9083345 53.42 µM -0.0399014627007888 0.486672510038028 no 1734 0.484085842483387 2500 17741579 SGTC_2174 5790901 200 µM -0.0400267066627809 0.486623490981251 no 1735 0.48403591725603 2507 786020 SGTC_2772 vinpocetine 57.06 µM -0.040482404232358 0.486445137866302 no 1736 0.483854267464974 2499 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1829 berberine 14.4 µM -0.0407652220946215 0.486334448607096 no 1737 0.483741532523739 2578 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2296 7971656 126.45 µM -0.0407742783413963 0.486330904190447 no 1738 0.483737922605399 2499 666570 SGTC_276 colchicine 750 µM -0.0408089768242773 0.486317323974168 no 1739 0.483724091425544 2554 2833 A microtubule depolymerizer. SGTC_2195 6536160 144.242 µM -0.0435308509293499 0.485252093551882 no 1740 0.482639186171083 2488 3834386 SGTC_289 k017-0060 526 µM -0.0437631060376939 0.485161203148351 no 1741 0.482546618004638 2498 5512909 SGTC_887 0885-0007 9.62 µM -0.0443110261683582 0.484946783880201 no 1742 0.482328241348557 2601 5719458 SGTC_993 3909-8757 62.7 µM -0.0454744519340725 0.484491511410583 no 1743 0.481864569114896 2525 4288324 YLR208W SEC13 SGTC_1175 0741-0056 27.6 µM -0.0456999522944064 0.484403270794662 no 1744 0.481774700917366 2515 765927 SGTC_689 0833-0039 98 µM -0.0488654121112374 0.483164676328773 no 1745 0.480513276526977 2531 5374726 SGTC_1005 4092-0690 4.4 µM -0.0489868888080514 0.483117147575021 no 1746 0.480464872305491 2513 1529343 SGTC_73 0327-0325 16.231 µM -0.049672008594574 0.482849093352245 no 1747 0.480191881410256 2575 53298 SGTC_474 dl-dihydrosphingosine 5 µM -0.0497571636145236 0.482815776852379 no 1748 0.480157951427994 2611 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3126 9127922 49.47 µM -0.0503690559748785 0.482576380395867 no 1749 0.479914147414531 2629 45595682 SGTC_873 0591-4978 488 µM -0.0503805809612776 0.482571871426042 no 1750 0.479909555440222 2507 3305145 SGTC_1507 4075-3230 155 µM -0.0507833433752455 0.482414298364824 no 1751 0.479749081905352 2467 659771 SGTC_3014 9081533 49.47 µM -0.0515789068598154 0.482103057522193 no 1752 0.479432113425618 2511 21367265 SGTC_2211 7117706 200 µM -0.0530255531180652 0.481537127752965 no 1753 0.478855773952968 2493 822771 SGTC_332 4112-0506 40.9 µM -0.0537289988405926 0.481261952307456 no 1754 0.478575539215644 2503 2790355 SGTC_1023 4482-3888 16 µM -0.0542654234136391 0.481052118555608 no 1755 0.478361848531795 2493 3303168 SGTC_3162 9099653 49.47 µM -0.0548678985465485 0.480816454000269 no 1756 0.478121853293477 2498 25237511 SGTC_1310 1188-0297 994 nM -0.0557065974258351 0.480488399194974 no 1757 0.477787771840171 2548 1588352 SGTC_2104 5389443 200 µM -0.0573749154571357 0.479835880598411 no 1758 0.477123272321624 2590 2244536 SGTC_3344 9148862 3.898 µM -0.0575990517286503 0.479748219686131 no 1759 0.47703400251581 2556 4905352 SGTC_1460 k062-0059 9.15 µM -0.0577896167733817 0.479673689433095 no 1760 0.476958104486055 2460 1373085 SGTC_81 0411-0046 9.971 µM -0.0598624159713097 0.478863061251533 no 1761 0.476132606948328 2501 12925265 SGTC_829 1635-0120 117 µM -0.0612581782151208 0.478317257036208 no 1762 0.475576798583375 2574 285054 SGTC_2626 ethyl orsellinate 100 µM -0.0625023591635787 0.477830761998302 no 1763 0.475081391637153 2534 75653 A natural product. SGTC_1853 st056710 91.2 µM -0.0625316941648491 0.477819291930249 no 1764 0.475069711512343 2638 269167 SGTC_3322 9139058 2.11 µM -0.0625457315413375 0.477813803283036 no 1765 0.47506412234991 2646 4908926 YPR165W RHO1 SGTC_1883 5-benzylidenerhodanine 20 µM -0.0629639067364015 0.477650297733028 no 1766 0.474897622759813 2542 1273210 SGTC_1418 3966-3099 2.4 µM -0.0631921568335956 0.477561054049573 no 1767 0.474806745119399 2520 740335 SGTC_630 4356-0227 183 µM -0.0636286911250738 0.47739037630437 no 1768 0.474632942905624 2516 779312 SGTC_667 1498-1044 59 µM -0.065281633288162 0.476744140885061 no 1769 0.473974882829927 2563 6739982 SGTC_3261 9137475 49.47 µM -0.0662639731946908 0.476360113454601 no 1770 0.473583832692141 2513 17027690 SGTC_2981 9013952 38.96 µM -0.0670019170141349 0.476071642529703 no 1771 0.473290088537605 2582 2996344 SGTC_120 rhodamine 6G 52.259 µM -0.0680230802034052 0.475672478535222 no 1772 0.472883630744749 2534 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_920 mycophenolic acid 780.421 nM -0.0691311368613491 0.475239376254752 no 1773 0.472442618338428 2552 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2682 pyrogallin 40.03 µM -0.0693854334091318 0.475139984350042 no 1774 0.472341411714752 2541 822798 An ATP competetive kinase inhibitor. SGTC_3282 9108498 15.4605 µM -0.0697231422610332 0.475007993106274 no 1775 0.472207010871542 2599 16459645 SGTC_1784 st039334 36.3 µM -0.0710368183787262 0.474494577810087 no 1776 0.471684226332826 2713 3496984 SGTC_946 3434-1334 87.4 µM -0.0728397467204671 0.473790020447293 no 1777 0.470966820817993 2622 4047976 SGTC_2639 lactacystin 53 µM -0.0734437265562339 0.473554012405207 no 1778 0.470726511382428 2580 3870 A proteasome inhibitor. SGTC_2674 ligustilide 100 µM -0.0740541190509759 0.473315508016444 no 1779 0.470483661330212 2594 5319022 A signalling regulator. SGTC_2747 doxorubicin 7.63 µM -0.0746004419926263 0.473102046235209 no 1780 0.470266311222885 2523 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2166 5933061 31.504 µM -0.0747158494682698 0.473056954688236 no 1781 0.470220398435106 2829 2877375 SGTC_1180 1193-0155 285 µM -0.0754561360671468 0.472767721106238 no 1782 0.469925898171575 2608 2921347 SGTC_2497 7-hydroxyflavone 100 µM -0.0758297982479782 0.472621734914223 no 1783 0.469777254398133 2669 5281894 SGTC_793 0488-0545 106 µM -0.0780629493310019 0.471749341774847 no 1784 0.468888989686922 2541 292548 SGTC_260 nsc-65238 3.989 µM -0.0788056622954853 0.471459226568451 no 1785 0.468593600098378 2551 3246252 SGTC_3211 9128781 49.47 µM -0.0797944070310772 0.471073031061839 no 1786 0.468200386342013 2677 17194361 SGTC_3313 9133968 57.047 µM -0.0801393459498695 0.470938307157999 no 1787 0.468063214910899 2537 1494643 SGTC_2443 5493264 126.67 µM -0.0803305794515094 0.470863617905803 no 1788 0.46798716895475 2621 5340055 SGTC_2020 4017018 200 µM -0.0806104674578776 0.47075430509067 no 1789 0.467875870735691 2614 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1495 4469-0029 237 µM -0.0818800890482487 0.470258470583156 no 1790 0.467371033951623 2547 793680 SGTC_2744 captopril 92.04 µM -0.0822900644133681 0.470098369748601 no 1791 0.46720802753713 2571 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3204 9114183 49.47 µM -0.0825091468811136 0.470012817110213 no 1792 0.467120922488892 2549 17027248 SGTC_2303 7774051 200 µM -0.0829770451428452 0.46983010548283 no 1793 0.466934895990026 2634 2953184 SGTC_2528 xanthyletin 44.79 µM -0.0832302893645064 0.469731217692225 no 1794 0.466834214428442 2587 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3028 9087778 49.47 µM -0.0833812018636403 0.46967228967879 no 1795 0.466774217597982 2572 17217395 SGTC_3024 9090631 49.47 µM -0.083948859943744 0.469450637636349 no 1796 0.466548546008042 2545 25236383 SGTC_569 4130-2812 160 µM -0.0853719775799782 0.468894998190767 no 1797 0.465982835231437 2554 743552 SGTC_1712 st032288 53.4 µM -0.0856094457773293 0.468802287410721 no 1798 0.465888444692766 2564 2883011 SGTC_3330 9141424 71.43 µM -0.0871727894991312 0.468191979444167 no 1799 0.465267083918034 2645 27261020 SGTC_2745 rifampicin 24.3 µM -0.0879323086954573 0.467895500448453 no 1800 0.46496523871441 2633 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2488 5268135 45.7 µM -0.0881795625129923 0.467798988534273 no 1801 0.464866980392284 2644 1270356 YLR208W SEC13 SGTC_468 gf-109203x 121 µM -0.089054152996013 0.467457620147749 no 1802 0.464519436585818 2565 2396 A protein kinase C inhibitor. SGTC_268 camptothecin 39.6153 µM -0.0900833846945314 0.467055923187175 no 1803 0.46411047631255 2559 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1452 4194-0072 190 µM -0.091813474711931 0.466380765319306 no 1804 0.463423119005928 2684 1343545 SGTC_2925 9010536 32.5 µM -0.0922443470153974 0.466212634804113 no 1805 0.463251952198092 2629 2994177 SGTC_2343 7990716 14.84 µM -0.0925881710931811 0.466078475667491 no 1806 0.463115370739316 2590 6456862 SGTC_1337 1486-1011 40.3 µM -0.0929639894977626 0.465931836849209 no 1807 0.46296608475553 2573 X1337 SGTC_2859 9028643 45.46 µM -0.0930058830992428 0.465915490867763 no 1808 0.462949443723184 2671 17151580 SGTC_1375 2910-0797 186 µM -0.0933544274060068 0.465779498614292 no 1809 0.462810997004516 2633 742508 SGTC_3158 9100007 49.47 µM -0.0934424668217079 0.465745148724794 no 1810 0.462776027217821 2596 19297233 SGTC_102 gallobenzophenone 83.616 µM -0.0945345026455941 0.465319095976675 no 1811 0.462342288004973 2621 70837 SGTC_1301 naphtanilide LB 4.81 µM -0.0945486092576669 0.46531359260595 no 1812 0.462336685375464 2636 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_212 3807-4682 38.772 µM -0.0967677862200862 0.46444791497299 no 1813 0.46145540335693 2652 3125501 YBL034C STU1 SGTC_1150 3909-7983 10.9 µM -0.0979292525581369 0.463994905967675 no 1814 0.460994235720063 2606 23965914 SGTC_1942 st076330 65.2 µM -0.0980681151730245 0.463940748220517 no 1815 0.460939102929057 2716 24208414 SGTC_3280 9140961 49.47 µM -0.0986077524195581 0.463730290888817 no 1816 0.460724857241687 2568 4901226 SGTC_2829 7992743 58.44 µM -0.0988974496611008 0.463617313788799 no 1817 0.460609846928045 2629 16462845 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0990158350596984 0.463571146298719 no 1818 0.460562848664749 2640 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_215 1287-0124 461.5 µM -0.0996441868292648 0.463326112278719 no 1819 0.460313406177339 2658 5560863 SGTC_1800 st050079 29.0735 µM -0.100583320925592 0.462959910576265 no 1820 0.459940618761979 2618 3645560 SGTC_3087 9117406 49.47 µM -0.100761184796079 0.462890558668768 no 1821 0.459870020007712 2689 42546093 SGTC_1607 st000305 50.6 µM -0.100883376754736 0.462842914764711 no 1822 0.459821519603129 2702 5457690 SGTC_2213 7173844 200 µM -0.10101835787276 0.462790284855263 no 1823 0.459767943623338 2594 892728 SGTC_2279 7948423 32.93 µM -0.101053806563417 0.462776463316111 no 1824 0.459753873640672 2575 1247112 SGTC_1502 4534-4282 27.7 µM -0.102189402217189 0.462333715408466 no 1825 0.459303169761922 2614 3278949 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.105848491087396 0.460907423974232 no 1826 0.457851281268653 2605 689007 SGTC_255 tunicamycin 200.472 nM -0.106354474842975 0.460710233619556 no 1827 0.457650555978203 2677 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.107248816312148 0.460361717410989 no 1828 0.457295794455425 2782 94937 An inhibitor of serotonin biosynthesis. SGTC_398 bronopol 33.3 µM -0.107338245927241 0.460326869226344 no 1829 0.457260321967504 2594 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2429 5902844 64.44 µM -0.107901447017728 0.46010741274773 no 1830 0.457036934635601 2724 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_210 3551-0445 56.827 µM -0.109707058125842 0.459403922052566 no 1831 0.456320851316685 2730 2865180 YOR207C RET1 SGTC_1656 st012921 11 µM -0.110010886201008 0.459285558926074 no 1832 0.456200370690035 2684 6732821 SGTC_1926 methyl fluorone black 53.6 µM -0.110712832847033 0.45901211348702 no 1833 0.455922034701768 2593 72721 Reacts with homocysteine. SGTC_844 0330-0132 15.3 µM -0.111206954541729 0.458819638508322 no 1834 0.45572611845801 2671 2828079 SGTC_440 fluspirilene 35.1 µM -0.111248310190733 0.458803529700048 no 1835 0.455709721682503 2864 3396 An atypical antipsychotic. SGTC_3177 9107506 49.47 µM -0.111712959334603 0.458622544717353 no 1836 0.45552550179527 2643 8897194 SGTC_3062 9077494 49.47 µM -0.112008948511708 0.458507258764591 no 1837 0.455408155668436 2671 16459633 SGTC_1752 st044819 83.042 µM -0.112571562273372 0.45828813381589 no 1838 0.455185115862021 2650 441209 YML126C ERG13 SGTC_845 0330-0138 4.51 µM -0.113336096089303 0.457990386040439 no 1839 0.454882050524963 2587 9039800 SGTC_1379 2144-0755 36.5 µM -0.113412837379046 0.457960500436126 no 1840 0.454851631310208 2663 5392327 SGTC_1318 1280-3875 124 µM -0.113903611728368 0.4577693822492 no 1841 0.454657101229177 2671 373245 SGTC_1908 st060353 56.5 µM -0.115580152372251 0.457116574841644 no 1842 0.4539926467909 2715 4227716 SGTC_2025 5147754 141 µM -0.116342013135918 0.456819961438292 no 1843 0.453690744999417 2687 315777 YLR208W SEC13 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.116523497779576 0.456749308003668 no 1844 0.453618832203701 2603 3256 An antibiotic and ribosome inhibitor. SGTC_501 nsc-95397 161 µM -0.118522816578075 0.455971048066904 no 1845 0.452826708748789 2784 262093 SGTC_2451 5856223 45.7 µM -0.11988344913707 0.455441501166461 no 1846 0.452287737792611 2659 2179896 SGTC_808 0711-0032 135 µM -0.120857354770945 0.455062513727329 no 1847 0.451902010229654 2595 4252555 SGTC_303 1348-1668 34.2 µM -0.121604756610504 0.454771696110586 no 1848 0.451606023110278 2656 5380509 SGTC_1142 3253-1408 9.78 µM -0.123101082308098 0.454189541650867 no 1849 0.451013527121149 2603 256655 SGTC_982 1491-0518 27.5 µM -0.123328188690708 0.454101193124616 no 1850 0.450923609934801 2676 3091256 SGTC_343 4130-2827 29.8 µM -0.123397405739254 0.454074266881261 no 1851 0.45089620564741 2653 1118244 SGTC_1873 rapamycin 2 nM -0.124762310454949 0.453543346220711 no 1852 0.45035586304645 2645 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.12550541312705 0.453254328971974 no 1853 0.450061719934717 2722 6728940 SGTC_882 0843-0131 351 µM -0.127737943103653 0.452386173634902 no 1854 0.449178180895491 2618 5425421 SGTC_2101 5377231 179.231 µM -0.128340845887662 0.452151764007175 no 1855 0.448939621009811 2734 2844213 SGTC_1939 st074455 53.6 µM -0.129079471146614 0.451864607991255 no 1856 0.448647382877291 2819 1644229 SGTC_2419 paclitaxel 166.5 µM -0.129759164057334 0.451600385402324 no 1857 0.448378486023673 2586 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1803 st050068 52.4 µM -0.130629116386654 0.451262233008937 no 1858 0.448034354267909 2630 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1176 0848-0131 83.3 µM -0.131374583362329 0.450972496474281 no 1859 0.447739496960181 2732 6769040 SGTC_2692 st077426 47.7 µM -0.131668189463945 0.45085838937269 no 1860 0.447623373770882 2705 25238571 SGTC_2887 9044784 58.44 µM -0.132745878746505 0.450439590995854 no 1861 0.447197178960061 2657 6465546 SGTC_820 1582-0060 59.9 µM -0.133206473902358 0.450260616965324 no 1862 0.447015045521622 2680 3848840 SGTC_768 0384-0033 77.3 µM -0.134249443098195 0.449855386572228 no 1863 0.446602664901052 2650 3965305 YMR134W ERG29 SGTC_38 0929-0051 58.268 µM -0.134996586562181 0.449565127047819 no 1864 0.446307286577884 2743 1379719 SGTC_1934 st074720 32.6 µM -0.135319269480749 0.449439775535079 no 1865 0.446179725180782 2649 17250992 SGTC_618 k072-0232 33.2 µM -0.135830516619796 0.449241183468998 no 1866 0.445977632927687 2731 5872756 YGL099W LSG1 SGTC_477 mead ethanolamide 10 µM -0.136984675243048 0.448792901634413 no 1867 0.44552145415001 2626 16061185 SGTC_2989 9073649 71.4286 µM -0.137901517374664 0.448436841446116 no 1868 0.445159125587995 2624 21367202 SGTC_109 0132-0036 33.701 µM -0.14018641412067 0.447549671800051 no 1869 0.444256352932594 2629 67274 A color developer. SGTC_410 α-linolenic acid 100 µM -0.140305523826984 0.44750343156375 no 1870 0.44420930005754 2770 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_936 3005-4620 401 µM -0.141334587115169 0.447103963002959 no 1871 0.443802813638867 2805 777207 SGTC_288 1315-0019 35.1 µM -0.141464240175854 0.447053637222223 no 1872 0.443751604055585 2705 6811474 SGTC_162 k030-0015 37.8 µM -0.141838271591232 0.446908458981674 no 1873 0.443603876651056 2746 1809920 YMR134W ERG29 SGTC_2796 7949634 45.45 µM -0.143402931896698 0.446301222025272 no 1874 0.442985983794569 2646 2971588 SGTC_502 l-744,832 89.3 µM -0.14350273143081 0.446262494574329 no 1875 0.442946577103577 2761 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2934 9036370 36.88 µM -0.144417623049485 0.445907492600511 no 1876 0.442585350751809 2762 6462800 SGTC_1407 3909-7909 12.3 µM -0.144964138710819 0.445695450840356 no 1877 0.442369592906162 2674 4411780 SGTC_1497 4476-2978 41.3 µM -0.144968685028941 0.445693686986526 no 1878 0.44236779814575 2744 1528379 SGTC_2762 leflunomide 42.06 µM -0.145070786434117 0.445654074565621 no 1879 0.442327491651955 2668 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3338 9144300 39.5675 µM -0.145101753690622 0.445642060264242 no 1880 0.442315266849717 2739 4901274 SGTC_2001 4023502 57.655 µM -0.145300541644598 0.445564938108957 no 1881 0.442236793546759 2766 108941 YCR052W RSC6 SGTC_3101 9120531 49.47 µM -0.145311235247908 0.445560789456497 no 1882 0.442232572216492 2851 24824904 SGTC_2192 5915882 198.485 µM -0.145335069673836 0.445551542758494 no 1883 0.442223163532793 2654 2876149 SGTC_2347 9049783 174.81 µM -0.145923037822543 0.445323446637387 no 1884 0.441991072350956 2788 6467988 YPL169C MEX67 SGTC_1650 st011916 45.8 µM -0.146281703368915 0.445184314956158 no 1885 0.441849504538996 2696 242528 SGTC_2298 7976326 193.81 µM -0.146704521417801 0.445020306240887 no 1886 0.441682624823644 2704 2235818 SGTC_2089 5281248 129.67 µM -0.147341271170856 0.444773332401272 no 1887 0.441431329129447 2671 2737878 SGTC_2026 5148700 152 µM -0.147425105255901 0.444740817570813 no 1888 0.441398245445392 2668 79838 SGTC_161 4065-0411 162.148 µM -0.147512254508576 0.444707017355434 no 1889 0.441363853920745 2789 1906281 YLR208W SEC13 SGTC_3105 9121040 49.47 µM -0.148450376622768 0.444343198899665 no 1890 0.440993672829282 2631 41448907 SGTC_1328 1441-0025 69.2 µM -0.148802464682466 0.444206665718481 no 1891 0.44085475287911 2650 4562601 SGTC_1477 0139-0234 16 µM -0.148962450078415 0.444144628553314 no 1892 0.440791631406383 2649 620880 SGTC_350 k064-0020 19.8 µM -0.149046305439919 0.44411211270121 no 1893 0.440758547275363 2813 2790705 SGTC_2050 5263056 171 µM -0.152693897837513 0.442698085084317 no 1894 0.439319836577078 2772 763468 YGL055W OLE1 SGTC_2697 mebhydrolin 72.4 µM -0.152752517348826 0.44267536652213 no 1895 0.439296721921052 2785 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2447 5741742 33.78 µM -0.153359981437107 0.442439949013109 no 1896 0.439057200847306 2757 1776504 SGTC_8 0354-0001 70 µM -0.15385705366962 0.442247328038891 no 1897 0.43886122351109 2687 4993152 SGTC_1554 st069299 38.7 µM -0.154666567245351 0.441933661840512 no 1898 0.4385420941215 2756 24207999 SGTC_2253 7938677 135.83 µM -0.155722199186268 0.441524685671158 no 1899 0.438125999106383 2892 2301972 SGTC_1386 3228-0095 33.8 µM -0.156028067031314 0.441406197039771 no 1900 0.438005448930436 2806 870181 SGTC_1909 st060837 51.5 µM -0.156137623221793 0.441363757884078 no 1901 0.437962271491511 2739 678937 SGTC_580 1123-0028 41 µM -0.15625579972542 0.441317980203037 no 1902 0.437915697509455 2672 1677248 YPR107C YTH1 SGTC_1768 st044301 37.178 µM -0.156903024324155 0.441067280653599 no 1903 0.437660638158584 2727 3931349 SGTC_1366 1683-0113 21.9 µM -0.157131824175269 0.440978661700276 no 1904 0.437570478522113 2686 708623 SGTC_1174 0739-0097 51.1 µM -0.157388819018153 0.440879125762998 no 1905 0.437469212384427 2745 728447 SGTC_1969 st069479 40.1 µM -0.157720507366793 0.440750666019388 no 1906 0.437338520105317 2836 3895485 SGTC_2418 pentamidine 31.67 µM -0.159441177577829 0.440084367167402 no 1907 0.436660649409088 2651 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2322 7413319 38.22 µM -0.159912896517865 0.439901731970156 no 1908 0.436474844653383 2809 1840400 SGTC_1107 amlodipine 47 µM -0.160876485257488 0.439528699559284 no 1909 0.436095341545732 2732 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_693 4161-2696 114 µM -0.161290851912283 0.439368303014285 no 1910 0.435932164022596 2805 805759 SGTC_2131 toluylene red 5.2905 µM -0.161961627922056 0.439108674479691 no 1911 0.435668035663542 2730 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1405 3909-7894 12 µM -0.16209813751083 0.439055840695077 no 1912 0.435614286425863 2795 7104060 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.162729367710238 0.438811547591262 no 1913 0.435365761548675 2725 676296 Flavone; oxidizing agent. SGTC_1371 2421-0008 32.7 µM -0.162839392920831 0.438768968994485 no 1914 0.435322445568858 2742 2827552 SGTC_1081 sertraline 6 µM -0.163454778133306 0.438530834482597 no 1915 0.435080188023046 2803 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1856 st057054 55.7 µM -0.165784558902877 0.437629485699804 no 1916 0.43416324908524 2942 1266018 SGTC_3271 9137798 49.47 µM -0.166465763372406 0.437366001303517 no 1917 0.433895212046976 2823 6498326 SGTC_1980 st071811 45.7 µM -0.166635126574474 0.437300497289178 no 1918 0.433828576546628 2847 4974850 SGTC_311 1315-0136 58 µM -0.168270817224421 0.436667955639991 no 1919 0.433185115482016 2856 6759207 SGTC_2896 9052656 71.43 µM -0.171343231893446 0.435480254079624 no 1920 0.431976944462907 2737 6469436 SGTC_506 n9-isopropylolomoucine 153 µM -0.171357216273825 0.43547484946771 no 1921 0.431971446805713 2768 6610355 SGTC_1321 1326-2144 215 µM -0.171363668343272 0.435472355908923 no 1922 0.431968910318365 2833 3513030 SGTC_1975 st070967 30.8 µM -0.171858069270838 0.435281290312584 no 1923 0.431774555957734 2778 261391 SGTC_117 lucigenin 22.078 µM -0.174289976193341 0.434341679218345 no 1924 0.43081878826008 2754 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_163 TUB2.036 7.546 µM -0.17437026927031 0.434310662834366 no 1925 0.430787239024074 2755 15992207 YJR013W GPI14 SGTC_31 0508-1974 57.237 µM -0.176409244264286 0.433523163936958 no 1926 0.429986221341746 2772 6810525 SGTC_1052 3253-3998 198 µM -0.176485701428396 0.433493639539754 no 1927 0.429956190489874 2687 5450317 SGTC_2602 kawain 100 µM -0.176876988028807 0.43334254766123 no 1928 0.429802507250538 2661 5369129 SGTC_17 0960-0276 49.807 µM -0.17717254878066 0.43322842593424 no 1929 0.429686428715909 2717 6821114 SGTC_87 0100-0052 35.5 µM -0.179822219844931 0.432205586447443 no 1930 0.428646069523246 2754 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_798 1287-0182 476 µM -0.182369338076695 0.431222763003224 no 1931 0.427646443473623 2857 1649755 SGTC_316 k060-0003 58.6 µM -0.182712377775595 0.431090431121455 no 1932 0.427511851597411 2866 6152314 SGTC_218 alverine citrate 93.75 µM -0.183916525836472 0.430625977179832 no 1933 0.427039470104535 2847 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1546 5-methoxyflavanone 78.7 µM -0.184378910356038 0.430447655541259 no 1934 0.426858106640653 2814 147795 SGTC_1923 st058458 19.1 µM -0.185239762611253 0.43011570000214 no 1935 0.426520491339668 2988 3534982 SGTC_1777 st045864 34.765 µM -0.187037494059087 0.429422631504863 no 1936 0.425815617818166 2737 4691462 SGTC_3009 9080819 71.4286 µM -0.187482673834123 0.42925103756195 no 1937 0.42564110355446 2804 17027216 SGTC_463 ikarugamyin 104 µM -0.187717719549222 0.42916044489884 no 1938 0.425548969505063 2720 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1471 k673-0312 37 µM -0.188207284465444 0.428971765974869 no 1939 0.425357081177283 2744 24099884 SGTC_562 3772-2733 112 µM -0.188210676414343 0.428970458770131 no 1940 0.42535575174126 2836 2876874 YIL048W NEO1 SGTC_121 0557-0495 61.343 µM -0.188642908738199 0.428803889485587 no 1941 0.425186350118505 2727 3104427 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.188734312195655 0.428768666976604 no 1942 0.425150528804623 3019 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3180 9109287 49.47 µM -0.189211783918966 0.428584681501137 no 1943 0.424963416126694 2866 18891271 SGTC_3 0833-0587 95.581 µM -0.189899088631303 0.428319867768821 no 1944 0.424694103320987 2782 5382644 SGTC_1764 st044502 93.5 µM -0.189964048995083 0.428294840659315 no 1945 0.424668651131706 2857 8407 SGTC_1612 st002233 45.4 µM -0.190461366530227 0.428103249995618 no 1946 0.424473807032888 2727 1035021 SGTC_2597 laccaic acid a 100 µM -0.19151586351364 0.427697063095671 no 1947 0.424060726637548 2863 5491415 A textile dye. SGTC_3010 9080089 71.4286 µM -0.1922690217447 0.427406997235807 no 1948 0.423765741365688 2855 17027233 SGTC_539 4859-0462 2.54 µM -0.193646748646797 0.426876491205165 no 1949 0.423226245422227 2922 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_420 mitomycin C 81.9 mM -0.195506339334309 0.426160649094678 no 1950 0.422498287684134 2759 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1743 st037606 46.3785 µM -0.195725377967642 0.426076347001865 no 1951 0.422412559914605 2763 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1359 1582-0056 520 nM -0.19585430982548 0.426026726168437 no 1952 0.422362100029532 2854 3661189 SGTC_1794 st048918 76.9 µM -0.195966291429532 0.425983629775621 no 1953 0.42231827497603 2710 672303 SGTC_633 0437-0093 97.7 µM -0.196721703142522 0.425692930860624 no 1954 0.422022662652781 2740 2831118 SGTC_710 3448-4187 58 µM -0.198406641578554 0.425044675491897 no 1955 0.421363460754899 2771 3946412 SGTC_153 4077-0274 519.67 µM -0.198637840278183 0.424955740950767 no 1956 0.421273025567128 3001 3121976 SGTC_792 4534-1957 155 µM -0.198782912690954 0.42489993831141 no 1957 0.421216281473422 2808 1717904 SGTC_2670 beta-carotene 100 µM -0.200035919524853 0.424418027350425 no 1958 0.420726244543588 2844 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_528 3492-0019 172 µM -0.201986258934523 0.423668144777617 no 1959 0.41996373328147 2798 2869262 SGTC_2696 st077691 74.316 µM -0.202832952965951 0.423342686743945 no 1960 0.4196328002592 2906 757133 SGTC_1026 k007-1105 30.6 µM -0.202964964324614 0.423291948023438 no 1961 0.419581208320077 2768 7066794 SGTC_2374 9071832 200 µM -0.205318618178768 0.422387532703664 no 1962 0.418661599355375 2752 17381698 SGTC_1673 st016611 27.3 µM -0.205375522186238 0.422365671807986 no 1963 0.418639371560531 2977 5226799 SGTC_2861 9024595 19.48 µM -0.206287656798149 0.422015288406252 no 1964 0.418283109818209 2819 16482810 SGTC_1984 st072354 53.1 µM -0.206798386313168 0.421819125939027 no 1965 0.418083658223918 2752 5762938 SGTC_1277 0873-0036 22 µM -0.207004506115563 0.421739964340995 no 1966 0.418003169674935 2845 5965735 SGTC_3181 9108277 49.47 µM -0.207828450555042 0.421423554948441 no 1967 0.417681458638004 2789 17097298 SGTC_2484 5809818 12.04 µM -0.207862179894249 0.421410603358808 no 1968 0.4176682901107 2820 2870548 SGTC_2648 atorvastatin 78.68 µM -0.208779630684625 0.421058347876242 no 1969 0.41731013664221 2876 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1353 1498-1206 8.11 µM -0.209214595394559 0.420891365118394 no 1970 0.417140359531412 2767 6756808 SGTC_1806 st050005 60.3 µM -0.209464096850165 0.420795588041985 no 1971 0.417042980127189 2770 5194765 SGTC_1486 3970-0793 4.53 µM -0.211706554701828 0.419934978258536 no 1972 0.416167987049288 2886 2844330 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.21311678610607 0.419393955842044 no 1973 0.415617935986584 2788 97141 SGTC_1146 3579-1023 7 µM -0.215095680137397 0.418635028300271 no 1974 0.414846360918013 2886 X1146 SGTC_759 3486-0358 89.3 µM -0.215851392793207 0.418345283945925 no 1975 0.414551793399808 2926 875103 SGTC_197 4544-0043 41.561 µM -0.216370583288039 0.418146249142107 no 1976 0.41434944715072 2797 896523 SGTC_1215 3852-0577 11.2 µM -0.220093683309418 0.416719593355016 no 1977 0.412899097094948 2956 2884876 SGTC_249 wiskostatin 11.211 µM -0.221518317056672 0.416173976477564 no 1978 0.41234443794453 2805 2775510 A n-wasp and actin depolymerizer. SGTC_156 3474-0145 5.642 µM -0.221745458148769 0.416086999185804 no 1979 0.41225602021645 2726 2265471 SGTC_2616 abietic acid 100 µM -0.222657692094022 0.415737726294 no 1980 0.411900965772862 2894 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1100 amiodarone 5.07 µM -0.224383289445769 0.415077217942922 no 1981 0.411229536150128 2916 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2690 usnic acid 100 µM -0.22450392909297 0.41503104955658 no 1982 0.411182604983931 3017 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2336 9001819 198.65 µM -0.226846164850109 0.414134917123735 no 1983 0.41027168246743 3036 2989602 SGTC_2933 9026794 32.47 µM -0.227467804052676 0.41389715466024 no 1984 0.410030000864866 2859 17586027 SGTC_1588 farnesol 29.9 µM -0.230307057486813 0.412811609104281 no 1985 0.408926588461504 2816 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_550 4123-0385 25.7 µM -0.230985550810288 0.412552295801955 no 1986 0.408663013653528 2816 5731123 SGTC_761 k216-0224 480 µM -0.232422639975298 0.412003180976117 no 1987 0.408104883087101 2994 1340404 SGTC_479 n-linoleoylglycine 10 µM -0.233293413641107 0.411670540244077 no 1988 0.407766786338119 2832 6433346 An anti-infammatory. SGTC_579 4491-1009 110 µM -0.233360136198277 0.411645054444518 no 1989 0.407740882688806 2881 1271041 SGTC_1758 st042942 75.2445 µM -0.233579816364524 0.411561146555867 no 1990 0.407655599270003 2808 669317 SGTC_1217 1183-1422 255 µM -0.233879715094007 0.411446605334058 no 1991 0.407539180763779 2957 2849664 SGTC_259 usnic acid 108.925 µM -0.234859190546559 0.411072563960119 no 1992 0.407159012450371 3021 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2532 xanthone 78.9 µM -0.235813522172464 0.410708202234968 no 1993 0.40678868742835 2933 7020 An insecticide. SGTC_1996 st072960 66.8 µM -0.238472638869107 0.409693364637896 no 1994 0.405757267146181 2914 1719405 SGTC_1565 sinapyl alcohol 95.1 µM -0.239522138149909 0.409292994933513 no 1995 0.405350366109951 2915 5280507 A phenol propionate derived from cinnamic acid. SGTC_737 1950-0117 57.9 µM -0.239641379672017 0.409247511891025 no 1996 0.405304141479141 2948 5393513 SGTC_94 0334-0113 514.748 µM -0.23969447987589 0.409227257939966 no 1997 0.405283557318562 2848 6795178 SGTC_1061 3448-9325 110 µM -0.239798790565396 0.409187471536556 no 1998 0.405243122304811 2801 723482 SGTC_524 r073-0010 27.8 µM -0.239873655741688 0.409158916879586 no 1999 0.405214102178326 2816 2772106 SGTC_2309 7664088 163.95 µM -0.240297171094406 0.408997391102289 no 2000 0.405049943957757 2984 704922 SGTC_3119 9125183 49.47 µM -0.240712582628596 0.408838971075913 no 2001 0.404888943076334 2892 22695334 SGTC_1440 4100-1550 40 µM -0.241604285468103 0.408498964429543 no 2002 0.404543400565216 2845 742806 SGTC_2287 7945887 168.79 µM -0.243021330735354 0.407958786275131 no 2003 0.403994436587733 2939 1245853 SGTC_2163 5671233 125 µM -0.243185586157086 0.407896183342961 no 2004 0.403930816167871 3039 701023 SGTC_669 0108-0021 26.2 µM -0.244612425186828 0.407352468992979 no 2005 0.4033782711931 2891 17201 SGTC_2821 7996764 71.43 µM -0.244939901486261 0.407227705310604 no 2006 0.403251482804933 3059 2987135 SGTC_2916 7875993 68.79 µM -0.245165160222477 0.407141890488297 no 2007 0.403164275702838 2849 1299250 SGTC_2693 st077581 40.7 µM -0.245602033823313 0.406975471336817 no 2008 0.402995157344533 2948 25238761 SGTC_1696 st025591 34.7925 µM -0.246456424541852 0.406650055103956 no 2009 0.402664466196447 2844 2787147 SGTC_2571 chrysanthemic acid 100 µM -0.246967604066123 0.406455390303527 no 2010 0.402466647903769 2895 2743 An insecticide. SGTC_2587 piperic acid 92.2 µM -0.247153166297192 0.406384731149855 no 2011 0.402394844466213 2930 5370536 SGTC_459 nigericin 15.3 µM -0.24763086774889 0.406202844046154 no 2012 0.402210012705061 2955 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1463 k081-0032 34.1 µM -0.248112639981817 0.406019427472961 no 2013 0.40202362802486 2910 977755 SGTC_3005 9076496 71.4286 µM -0.250648400170364 0.405054373481847 no 2014 0.401042978981245 2940 21368410 SGTC_591 4299-0174 154 µM -0.250722829782621 0.405026055914557 no 2015 0.40101420436251 2897 5509088 SGTC_1362 1611-0397 101 µM -0.251687248760238 0.404659177090986 no 2016 0.400641406902734 2864 27816 SGTC_2608 thymoquinone 42.66 µM -0.252722199242672 0.404265560296607 no 2017 0.400241446049624 2857 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_890 0929-0006 47.2 µM -0.254122364009746 0.403733197921301 no 2018 0.399700513191919 2859 1378169 SGTC_384 k007-0144 5.16 µM -0.25568542057401 0.403139112430325 no 2019 0.399096876874098 2917 6824886 SGTC_699 0375-0592 111 µM -0.256665455952771 0.402766735151205 no 2020 0.398718520260306 2949 762578 SGTC_678 1218-2179 85.9 µM -0.257241271643076 0.402547987543628 no 2021 0.398496262772289 2869 6820081 YOR116C RPO31 SGTC_551 k048-0028 34.9 µM -0.257647339977433 0.402393743888598 no 2022 0.398339545380384 3025 6836383 SGTC_765 1319-0117 244 µM -0.258932423550997 0.401905709573175 no 2023 0.397843690351229 2849 3487746 YGL099W LSG1 SGTC_1264 0783-0040 158 µM -0.259166861225645 0.401816693990008 no 2024 0.397753249335452 2812 2855798 SGTC_330 1488-0319 80.1 µM -0.25918610104272 0.401809388890542 no 2025 0.397745827271492 2919 6846614 SGTC_2919 7978188 46.38 µM -0.262283259608687 0.400633888456281 no 2026 0.396551533640235 3042 2980291 SGTC_1775 st081588 35.1725 µM -0.263405138895293 0.400208309943145 no 2027 0.396119165079644 2877 1426443 YGL099W LSG1 SGTC_2218 6965428 192.983 µM -0.263736723194642 0.400082547988943 no 2028 0.395991398025212 2918 675684 SGTC_295 k015-0027 31 µM -0.264668576893848 0.399729173796128 no 2029 0.395632393231895 2941 3887424 SGTC_518 1021-0119 62.6 µM -0.264762104383062 0.3996937111691 no 2030 0.39559636583204 2912 1097762 SGTC_1755 st041960 45.185 µM -0.26605958224956 0.399201834617783 no 2031 0.395096661044048 2996 2257073 SGTC_1889 st059080 5.18 µM -0.267087544594378 0.398812245508901 no 2032 0.394700878666192 3041 176925 Isolated from Daphnopsis sellowiana. SGTC_771 0250-0039 27.3 µM -0.267442458092232 0.398677759657564 no 2033 0.394564256355394 2886 3005115 SGTC_612 0302-0167 22.4 µM -0.268555812425467 0.398255959200402 no 2034 0.394135759966827 2953 235821 SGTC_3144 9087057 49.47 µM -0.26857410445855 0.398249030153444 no 2035 0.394128720985142 2954 17249618 SGTC_1037 k284-1091 78.7 µM -0.272313145421493 0.396833352898098 no 2036 0.392690624719365 2857 3334711 SGTC_1684 st024538 14.6195 µM -0.272966098032009 0.396586270524555 no 2037 0.392439638051066 2882 6732859 SGTC_284 0988-0104 32.6 µM -0.274365446546028 0.396056886063386 no 2038 0.391901897082032 2973 4666532 SGTC_2242 6630449 61.2675 µM -0.274595636285893 0.395969821817481 no 2039 0.39181345962467 3046 691249 YDR170C SEC7 SGTC_660 4031-1742 102 µM -0.276306307772157 0.39532296051918 no 2040 0.391156405767465 2880 6738706 SGTC_1177 0983-0204 23.6 µM -0.278377303873831 0.394540234541838 no 2041 0.390361370049219 3050 766818 SGTC_3056 9094900 49.47 µM -0.280796878776004 0.393626303607144 no 2042 0.389433098864902 2947 25236784 SGTC_2920 7982904 15.77 µM -0.280979679777465 0.393557279059231 no 2043 0.389362992717128 3008 6456808 SGTC_2271 7849410 118.62 µM -0.281525776430813 0.39335109620923 no 2044 0.389153580238769 2981 972430 SGTC_2326 6164455 177.58 µM -0.282206600735573 0.393094087822218 no 2045 0.388892548644248 2981 2888790 SGTC_1485 3909-9022 254 µM -0.28256474824831 0.392958907296069 no 2046 0.388755253138991 2926 714516 SGTC_709 3807-1509 243 µM -0.282941369339023 0.392816767958015 no 2047 0.388610890792679 2889 1886677 YPL242C IQG1 SGTC_3145 9085516 49.47 µM -0.283048250252595 0.392776432983486 no 2048 0.388569925151614 2998 25236195 SGTC_1221 2958-7315 257 µM -0.286559093948324 0.391452144923538 no 2049 0.387224969813289 2990 4562705 SGTC_2475 5812728 15.03 µM -0.287790247504169 0.390988051488177 no 2050 0.386753651532007 2883 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1049 3226-0134 66 µM -0.291183892795847 0.389709594415609 no 2051 0.385455340392793 2957 5702385 SGTC_575 k072-0246 11.9 µM -0.291769496324981 0.38948910558576 no 2052 0.385231434663671 2908 6796779 SGTC_2724 maprotiline 69.64 µM -0.292821293361792 0.389093177012213 no 2053 0.384829375773999 3025 4011 A tricyclic antidepressant. SGTC_2463 5473429 200 µM -0.293925207570816 0.388677753776327 no 2054 0.384407527797889 2986 5399405 SGTC_1222 0366-0074 1.18 µM -0.294110059307738 0.388608203093281 no 2055 0.384336902220643 3050 286520 SGTC_1594 piperine 70.1 µM -0.29567012121208 0.388021370411409 no 2056 0.383741008653043 2914 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_257 daunorubicin 18.5 µM -0.298206035528677 0.387068007198025 no 2057 0.382772957781221 3037 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2663 amphotericin b 100 µM -0.298632432840431 0.386907772156155 no 2058 0.382610258107545 2954 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2126 5251174 33.877 µM -0.299180616147026 0.386701799705021 no 2059 0.382401119205918 3101 790722 SGTC_432 NS 1619 61.3 µM -0.299672085933822 0.386517163717608 no 2060 0.382213646389825 3110 4552 A K+/calcium channel activator. SGTC_2135 5326629 150.42 µM -0.300743159959505 0.38611487032849 no 2061 0.381805177276605 2979 5020077 SGTC_2078 5212016 200 µM -0.302026202941768 0.385633122981742 no 2062 0.381316044046408 2936 1899708 SGTC_77 0828-0286 12.516 µM -0.304055990141006 0.384871354190649 no 2063 0.380542617582372 2943 745345 SGTC_235 0330-0087 5 mM -0.304706871206832 0.384627175757634 no 2064 0.380294707935155 2975 46494818 YHR062C RPP1 SGTC_1695 st026914 34.495 µM -0.305037001484812 0.384503344665968 no 2065 0.380168985652025 2915 3289191 SGTC_640 3381-0960 37.1 µM -0.305714917314382 0.38424909698921 no 2066 0.379910857197648 3009 1745025 SGTC_1256 0570-0116 285 µM -0.306590726867351 0.383920704364833 no 2067 0.379577456412726 2974 410638 SGTC_2278 7948257 134.34 µM -0.306734946740385 0.383866635818605 no 2068 0.379522563763296 3092 1247028 SGTC_2678 equilin 100 µM -0.307473905773769 0.383589632921527 no 2069 0.3792413409272 3049 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2836 9010338 19.48 µM -0.307998818693584 0.383392902524277 no 2070 0.37904161561093 2945 2994051 SGTC_784 4579-0127 173 µM -0.308089930828288 0.383358757965659 no 2071 0.37900695143376 3136 1948547 SGTC_2231 micatex 6.853 µM -0.310088841837056 0.382609888191232 no 2072 0.378246698635335 2997 20737 An antifungal of unknown mechanism. SGTC_1962 st076595 64.5 µM -0.311020360089571 0.38226105493053 no 2073 0.377892571800788 2957 279619 SGTC_1148 3909-7663 27.7 µM -0.312125654681488 0.381847270172991 no 2074 0.377472515089597 3072 4084526 SGTC_1165 k072-0275 30.3 µM -0.31245226776478 0.38172502313688 no 2075 0.377348416602153 3072 6153523 YGL055W OLE1 SGTC_103 0844-0104 51.839 µM -0.312776335179239 0.381603740568819 no 2076 0.377225297872 3071 5375804 SGTC_21 0849-0113 22.993 µM -0.313068097139248 0.381494558293101 no 2077 0.377114463208677 2960 1560156 SGTC_857 0438-0306 1.35 µM -0.313093601388234 0.381485014618435 no 2078 0.37710477512423 3056 4686136 SGTC_3323 9138564 53.9225 µM -0.313650434809471 0.381276665856332 no 2079 0.376893274790739 3132 43912313 YNL103W MET4 SGTC_2962 9082311 13.18 µM -0.314106457788449 0.381106062670657 no 2080 0.376720092486706 2914 16459453 SGTC_510 ag-490 170 µM -0.314513098854431 0.380953953286153 no 2081 0.376565684704874 3025 5328779 SGTC_851 0394-0702 453 µM -0.317919650988742 0.379680412744677 no 2082 0.375272943008286 3101 762646 SGTC_379 3970-0972 5.9 µM -0.318482153653803 0.379470246030688 no 2083 0.375059614894709 3012 2898042 YBL034C STU1 SGTC_1512 0259-0544 12.2 µM -0.319358506142778 0.379142887226411 no 2084 0.374727335972177 2977 18476 SGTC_1219 1469-0211 33.1 µM -0.3201309855223 0.378854401750273 no 2085 0.374434518805868 3082 6822282 SGTC_738 1315-0003 72.4 µM -0.322225071556219 0.378072696865957 no 2086 0.373641096107682 3129 6251474 SGTC_3300 9124615 50.48 µM -0.323998906469212 0.377410929186185 no 2087 0.372969431063564 3157 24824903 SGTC_287 k060-0039 29.6 µM -0.324003802579883 0.377409103082673 no 2088 0.372967577677674 3107 5861974 SGTC_1913 st060213 96.1 µM -0.324641672787396 0.377171219938722 no 2089 0.372726141863322 3167 688959 SGTC_1993 st073995 70.8 µM -0.324646592625668 0.377169385347415 no 2090 0.37272427988373 3002 3098394 SGTC_732 3970-1727 52.7 µM -0.32662799025577 0.376430754592013 no 2091 0.371974635269723 3092 1275699 SGTC_2190 6049624 200 µM -0.327159805107319 0.376232580087663 no 2092 0.371773510179991 3065 2265554 SGTC_3277 9138724 49.47 µM -0.327687938022703 0.37603580990096 no 2093 0.371573812175809 3019 15943418 SGTC_1714 st033236 13.627 µM -0.328340186944094 0.375792841420317 no 2094 0.37132723103555 3180 2916566 SGTC_3015 9080845 49.47 µM -0.330986256368935 0.37480766319395 no 2095 0.370327433425153 3115 5296973 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.332073409583106 0.374403133172544 no 2096 0.369916914004932 2975 2346 DNA damaging agent; causes G2/M arrest. SGTC_1059 3448-6867 171 µM -0.332509806635332 0.374240788557094 no 2097 0.369752167970561 2993 3934407 SGTC_3110 9122132 49.47 µM -0.333273832859549 0.373956615908954 no 2098 0.369463794885273 3144 918317 SGTC_3288 9119690 36.221 µM -0.333911246200859 0.373719588176044 no 2099 0.369223266575896 3026 17595618 YKL019W RAM2 SGTC_1632 st005650 90 µM -0.337445357945569 0.372406266423131 no 2100 0.367890598457071 3100 2759605 SGTC_325 2810-4341 181 µM -0.338878265636308 0.371874200830584 no 2101 0.367350719103916 3113 774970 SGTC_1230 0170-0365 3.77 µM -0.339059732218842 0.371806836302617 no 2102 0.367282366272132 3116 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2365 9042475 200 µM -0.339060972692473 0.371806375824059 no 2103 0.36728189903867 3124 6464479 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.339819659521506 0.371524776634537 no 2104 0.366996170937402 2997 688803 SGTC_2467 5474540 200 µM -0.341316047631774 0.370969569016933 no 2105 0.366432834116738 3004 5413519 SGTC_1938 st074717 56.4 µM -0.341507222758259 0.370898656278886 no 2106 0.366360884190102 2943 17250979 SGTC_2998 9066762 71.4286 µM -0.341698702907498 0.370827634793359 no 2107 0.36628882417483 3198 4945196 SGTC_2080 5212524 12.4 µM -0.343785695017196 0.370053838932093 no 2108 0.365503729492032 3110 260183 SGTC_1108 betulinic acid 729.144 nM -0.344393264783533 0.369828668428513 no 2109 0.365275276679689 3045 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2109 5483026 200 µM -0.345037895120004 0.369589811752621 no 2110 0.365032940952602 3044 759335 SGTC_1411 3909-8223 150 µM -0.347258345044645 0.368767447936543 no 2111 0.364198620846865 3121 X1411 SGTC_555 4296-0685 37 µM -0.347818967440907 0.368559911140762 no 2112 0.36398807204061 3065 2908540 YHR072W ERG7 SGTC_1977 st070720 65.3 µM -0.349893241567779 0.367792369373595 no 2113 0.363209409643888 3123 682188 SGTC_3283 9109332 35.8195 µM -0.350044424791299 0.367736447777064 no 2114 0.363152678979885 3036 17027281 SGTC_2487 5918373 44.05 µM -0.35033213956844 0.367630031878334 no 2115 0.363044723903678 3150 2876279 SGTC_1994 st072947 40.9 µM -0.350354512612144 0.367621757277054 no 2116 0.363036329644242 3136 5286565 YDL195W SEC31 SGTC_1242 0402-0103 60.1 µM -0.351372469391466 0.367245334160051 no 2117 0.362654466770835 2995 432868 SGTC_1181 1222-0449 220 µM -0.351427977691122 0.367224811798362 no 2118 0.362633648042942 3201 658318 SGTC_1245 0418-0076 17.2 µM -0.351647329075584 0.367143717575476 no 2119 0.362551382936033 3191 6790114 SGTC_1796 st049173 110.4 µM -0.35196919681448 0.367024733778394 no 2120 0.362430681786919 3134 94134 SGTC_2947 9072639 7.68 µM -0.352064285586122 0.36698958506572 no 2121 0.362395025892767 3105 16488146 SGTC_960 1222-0186 7.7 µM -0.352791655653241 0.366720756138636 no 2122 0.362122319947407 3146 3126296 SGTC_1387 3342-1166 1.8 µM -0.353394884659099 0.366497858117606 no 2123 0.361896210101058 3079 3418228 SGTC_2991 9074669 71.4286 µM -0.353558888016275 0.366437265325218 no 2124 0.361834744639927 3219 17333109 SGTC_742 0kpi-0133 140 µM -0.354124726172934 0.366228235940181 no 2125 0.361622706208636 3182 2728852 SGTC_250 brefeldin a 552.239 µM -0.354714195926463 0.366010518885612 no 2126 0.361401857412513 3007 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2206 7254556 146.969 µM -0.354979210143733 0.365912651554386 no 2127 0.361302583100435 3071 4398905 SGTC_95 0471-0001 561.058 µM -0.356850863944064 0.365221715618365 no 2128 0.360601727912281 3035 4015405 SGTC_855 0428-0020 25 µM -0.35686653233406 0.3652159333497 no 2129 0.360595862735002 3058 6812414 SGTC_150 3970-0969 77.2 µM -0.36136767025489 0.363556105234298 no 2130 0.358912306401198 3142 6615640 SGTC_877 0771-0151 33.1 µM -0.36338883825604 0.36281161476021 no 2131 0.358157219260269 3124 6166523 SGTC_1373 2887-0003 58.5 µM -0.364148802745563 0.362531818298257 no 2132 0.357873447777421 3101 776948 SGTC_34 0469-0683 81.75 µM -0.364815252160786 0.362286511725012 no 2133 0.357624659531372 3114 3690923 SGTC_642 0335-0876 158 µM -0.365543108923033 0.362018666943566 no 2134 0.357353016775801 3055 6812350 SGTC_668 1682-0499 62.6 µM -0.367269834059915 0.361383517991257 no 2135 0.356708876567515 3096 682214 SGTC_1557 sumaresinolic acid 42.3 µM -0.368083926599561 0.361084199070432 no 2136 0.356405327781172 3049 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2708 st078559 56 µM -0.370762099624068 0.360100111131363 no 2137 0.355407366318331 3159 17250902 SGTC_2186 6124449 200 µM -0.371979402472579 0.359653122086065 no 2138 0.354954092586898 3184 3834182 YLR033W RSC58 SGTC_1476 4112-3294 3.34 µM -0.372476939928709 0.359470483414039 no 2139 0.354768889054647 3187 704369 SGTC_2119 5528445 120.635 µM -0.373491002678542 0.359098335333746 no 2140 0.35439152024877 3198 791935 SGTC_2636 apigenin dimethyl ether 100 µM -0.374475532450862 0.358737153351848 no 2141 0.354025278427702 3206 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1273 0849-0096 14.1 µM -0.376960507618592 0.357826084221746 no 2142 0.353101476969806 3116 5286025 SGTC_560 2332-1943 155 µM -0.378557258171117 0.357241092576667 no 2143 0.352508333429599 3076 21177716 SGTC_3098 9119039 49.47 µM -0.378958765002635 0.357094047712087 no 2144 0.352359242379531 3083 17161528 SGTC_2157 5649910 96.377 µM -0.379314974205765 0.356963610079016 no 2145 0.352226990631693 3055 2858091 SGTC_2072 5231554 129 µM -0.380030960915336 0.356701478751307 no 2146 0.351961216379602 3204 789545 SGTC_396 dithiazanine 1.25 µM -0.380325934365693 0.356593505103085 no 2147 0.351851743264911 3068 10578 An antihelmenthic. SGTC_1347 1493-0251 600 nM -0.380392833483526 0.356569018593084 no 2148 0.35182691679009 3192 3986378 SGTC_509 pifithrin 175 µM -0.38280330919827 0.355687127962705 no 2149 0.350932803835204 3182 4817 A p53 inhibitor. SGTC_213 1246-0773 967 nM -0.382826387194392 0.355678688427643 no 2150 0.350924247538423 3118 6251622 SGTC_1454 4239-0054 42.6 µM -0.383479784523739 0.355439772889559 no 2151 0.350682028188598 3257 1340767 SGTC_1055 3448-0672 86 µM -0.38448996196004 0.355070512075376 no 2152 0.35030766721087 3221 748378 SGTC_2274 7947094 46.08 µM -0.385815252929056 0.35458627088754 no 2153 0.349816749041607 3071 2971028 SGTC_973 1325-0077 65.9 µM -0.385830974255007 0.354580527962237 no 2154 0.349810927006584 3113 2835149 SGTC_1652 st011932 78 µM -0.388371091335921 0.353653070288873 no 2155 0.348870717163907 3178 1551076 SGTC_1726 st035556 14.5795 µM -0.388897342744808 0.353461031642966 no 2156 0.348676043966507 3267 5919439 SGTC_2424 5537928 59.2 µM -0.390958594148898 0.352709203314218 no 2157 0.347913920965389 3098 5382802 SGTC_983 1491-0821 12.2 µM -0.39122139930868 0.35261338806651 no 2158 0.347816795976734 3195 46495113 SGTC_279 1273-0055 2.93 µM -0.391271000987247 0.352595305006337 no 2159 0.3477984657882 3152 2847562 SGTC_361 000s-0510 1.45 µM -0.392132363289528 0.352281335186767 no 2160 0.3474802080522 3167 660 SGTC_1627 st003713 25.6 µM -0.393643368937781 0.351730811147269 no 2161 0.346922178652273 3184 16195070 YER133W GLC7 SGTC_1024 4507-0395 26 µM -0.393738354232922 0.351696214308088 no 2162 0.34688711071269 3253 4201836 SGTC_119 0121-0043 24.815 µM -0.39448181766914 0.351425462367687 no 2163 0.346612674281384 3149 1092378 SGTC_1967 st070177 51.4 µM -0.394563998632257 0.351395538612667 no 2164 0.346582343563606 3250 5729214 SGTC_2315 7733312 200 µM -0.394750993358437 0.351327453473713 no 2165 0.346513332653457 3079 726316 SGTC_2389 9091542 195.52 µM -0.395727556412896 0.350971962547655 no 2166 0.346153012226232 3140 3626624 YOL127W RPL25 SGTC_2711 st079103 59.1 µM -0.396256748867209 0.350779379042152 no 2167 0.34595781533692 3139 54693780 SGTC_2076 5212012 200 µM -0.397694891253906 0.35025620461199 no 2168 0.345427551841647 3125 604802 SGTC_2985 9022375 71.43 µM -0.400220268376678 0.349338198390553 no 2169 0.344497143697801 3285 4939335 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.400232152237272 0.349333880536092 no 2170 0.344492767622888 3136 88881 An O-methylated flavonoid and antioxidant. SGTC_2912 7964298 10.93 µM -0.400665266143198 0.349176527239185 no 2171 0.344333293346687 3187 2975850 SGTC_3139 9095020 49.47 µM -0.400728848725149 0.349153429426218 no 2172 0.34430988431389 3040 25236292 SGTC_2751 anetholtrithion 17.25 µM -0.400788975589076 0.349131587495136 no 2173 0.344287748112448 3218 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1117 retinoic acid 1.10837 µM -0.401682137489262 0.348807192726182 no 2174 0.343958986036205 3258 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1531 st059297 52.4 µM -0.402263881433255 0.348595963793983 no 2175 0.343744916542991 3222 7566702 SGTC_2706 st078239 82.5 µM -0.403206951455476 0.348253638519421 no 2176 0.34339799312348 3154 15434492 SGTC_2595 hexamethylquercetagetin 100 µM -0.403653043720475 0.348091754391168 no 2177 0.343233936869482 3149 386331 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.404284213326006 0.347862754129469 no 2178 0.343001866477028 3132 688669 SGTC_783 0848-0141 92.7 µM -0.404408001750769 0.34781784785491 no 2179 0.342956358508855 3137 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2404 5161160 200 µM -0.404686887458941 0.347716685328568 no 2180 0.342853840939074 3096 2831543 SGTC_1738 st035555 74 µM -0.406420351298663 0.347088134981953 no 2181 0.342216884417471 3216 5331140 SGTC_2537 larixol 68.93 µM -0.407545601281035 0.346680346624304 no 2182 0.341803654413705 3206 6708759 SGTC_956 1185-0240 191 µM -0.4082070778758 0.346440711664402 no 2183 0.34156082614065 3115 1416193 SGTC_2960 9079389 5.97 µM -0.409842450961355 0.345848524444943 no 2184 0.340960761736783 3269 16457355 SGTC_3212 9128307 49.47 µM -0.410802054180187 0.345501216553406 no 2185 0.340608843402178 3020 27243542 SGTC_902 1120-0002 2.07 µM -0.410901277181375 0.345465312319624 no 2186 0.340572462943715 3116 3280475 SGTC_1947 st076332 61.6 µM -0.411067710283321 0.345405090968319 no 2187 0.34051144299875 3247 24208416 SGTC_2105 5350118 200 µM -0.41110884116078 0.345390208972879 no 2188 0.340496363685859 3166 2133313 SGTC_3043 9092303 49.47 µM -0.412500392832818 0.344886857991102 no 2189 0.339986346413336 3182 25236084 SGTC_1227 3909-8010 46.6 µM -0.412566328444746 0.344863014615239 no 2190 0.339962187623825 3130 15982272 SGTC_381 3461-2219 42.7 µM -0.412638558149029 0.344836895901643 no 2191 0.339935723434934 3220 2883159 SGTC_148 3253-0744 288.01 µM -0.413252073579062 0.344615074703937 no 2192 0.33971096977639 3196 6893655 SGTC_2759 disulfiram 3.38 µM -0.414810013204903 0.34405202991153 no 2193 0.339140494400997 3086 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2145 5634607 200 µM -0.415575692415155 0.343775437362627 no 2194 0.338860258377117 3120 308662 SGTC_2205 7238770 200 µM -0.417315096263523 0.343147409182106 no 2195 0.338223973936534 3253 279867 SGTC_492 tmb-8 126 µM -0.417509015520068 0.343077419599919 no 2196 0.338153065676996 3170 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_729 4092-0585 94.1 µM -0.417804804029743 0.342970673607285 no 2197 0.33804491909785 3111 2169061 SGTC_719 2810-4230 27.3 µM -0.419270909914998 0.342441761368464 no 2198 0.337509076996186 3187 721079 SGTC_3316 9136639 10.545 µM -0.420304812832888 0.342068956254014 no 2199 0.337131397226422 3243 4903665 SGTC_3127 9126946 49.47 µM -0.423917637902369 0.340767452916667 no 2200 0.335812940230228 3184 27243249 SGTC_1193 1488-0126 41.5 µM -0.425259443150334 0.340284555149542 no 2201 0.335323777665621 3155 1384710 SGTC_980 1473-0395 201 µM -0.425552170898184 0.340179241107477 no 2202 0.335217099190808 3112 768876 SGTC_2775 cyproheptadine 69.59 µM -0.427014553220945 0.339653309758897 no 2203 0.334684363850119 3257 2913 A selective serotonin reuptake inhibitor. SGTC_2197 6588183 93.1375 µM -0.427194021027399 0.339588787413699 no 2204 0.334619007914096 3144 884136 SGTC_643 k048-0106 28.4 µM -0.428029301399283 0.339288548926412 no 2205 0.334314893795878 3251 6763920 SGTC_3019 9081971 49.47 µM -0.429931264772897 0.338605275935733 no 2206 0.333622820901815 3330 16451803 SGTC_707 0865-0008 204 µM -0.430157580317638 0.338524008251632 no 2207 0.333540508432763 3144 723043 SGTC_1161 k007-0610 110 µM -0.431561509184283 0.338020039342574 no 2208 0.333030069328116 3289 5843850 SGTC_2483 5729050 27.16 µM -0.433078493997822 0.337475812847407 no 2209 0.332478872995959 3339 2865180 SGTC_2084 5306078 60.6385 µM -0.433099612840946 0.337468238743899 no 2210 0.332471202018215 3157 679340 SGTC_2258 7960471 200 µM -0.433839550040135 0.337202907799315 no 2211 0.332202479631814 3218 2974708 SGTC_1761 st044296 37 µM -0.433976134383068 0.337153939445585 no 2212 0.332152885834133 3130 1826700 SGTC_672 1441-0018 53.7 µM -0.434022847845904 0.337137192321807 no 2213 0.332135924842559 3139 251141 SGTC_285 1486-1325 46 µM -0.435558014228392 0.336587003519823 no 2214 0.331578719363895 3283 22310230 SGTC_1657 st012939 43.4 µM -0.436268813549649 0.336332378255359 no 2215 0.331320853036722 3290 24207257 SGTC_1927 st060202 13.8 µM -0.436598181432858 0.336214416265533 no 2216 0.331201390875782 3310 688887 SGTC_65 0798-0905 34.986 µM -0.436628084133936 0.336203707512862 no 2217 0.331190545977486 3503 3602145 SGTC_302 1094-0063 18.9 µM -0.4368788661921 0.336113902696663 no 2218 0.331099599703772 3160 5440289 SGTC_2993 9054257 71.4286 µM -0.438218566640436 0.335634315791094 no 2219 0.330613925377537 3156 6470217 YGL055W OLE1 SGTC_2900 5328528 85.29 µM -0.438965037431801 0.335367209700657 no 2220 0.330343434992526 3202 795359 SGTC_2666 tannic acid 100 µM -0.439267283710026 0.335259082009644 no 2221 0.330233938541464 3283 16134267 A thiamine antagonist. SGTC_3303 9125618 40.5795 µM -0.439699611413653 0.335104441806038 no 2222 0.330077342033527 3222 22695467 SGTC_234 nsc-17383 10.7 µM -0.440052852743605 0.334978110916999 no 2223 0.329949414061061 3316 408974 SGTC_2097 5376186 200 µM -0.44053553412086 0.334805518132659 no 2224 0.329774640931189 3274 742755 SGTC_2439 5492030 7.2 µM -0.442760773760265 0.33401028900041 no 2225 0.328969389434653 3258 5722370 SGTC_3129 9127257 49.47 µM -0.443751184412167 0.333656587337225 no 2226 0.328611242562571 3161 837894 SGTC_1303 1160-0052 261 µM -0.445655070787677 0.332977074810074 no 2227 0.327923211871107 3254 3562476 SGTC_1634 st006576 41 µM -0.446906206767358 0.332530832479577 no 2228 0.327471391174758 3355 3915356 SGTC_2375 9072683 200 µM -0.447303969867263 0.33238901209058 no 2229 0.327327800518993 3354 16798029 SGTC_2504 purpurogallin 52.29 µM -0.447654351582908 0.332264105166125 no 2230 0.327201335487461 3160 5281571 An antioxidant. SGTC_1910 st062352 60.4 µM -0.449195582693208 0.33171489592191 no 2231 0.326645286881924 3141 2245730 SGTC_1053 3366-3204 134 µM -0.45074324884964 0.33116375732559 no 2232 0.326087303868901 3210 3632071 YPR165W RHO1 SGTC_2396 5342950 42.78 µM -0.451892933656588 0.330754580225594 no 2233 0.325673057655227 3254 1886677 SGTC_349 k015-0014 24 µM -0.452593482711151 0.330505351291712 no 2234 0.325420746294796 3131 2196908 SGTC_2313 7726885 200 µM -0.452877852604413 0.330404204645327 no 2235 0.325318349797747 3280 726423 SGTC_2963 9082507 9 µM -0.453330482095628 0.330243235818488 no 2236 0.325155393238531 3316 16459611 SGTC_493 zm226600 134 µM -0.453859700401751 0.33005506951293 no 2237 0.324964905423803 3350 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3218 9131285 49.47 µM -0.453986368409417 0.330010038421224 no 2238 0.324919319090811 3378 17156417 SGTC_842 0271-0008 11.1 µM -0.454016123493696 0.329999460701508 no 2239 0.324908610964531 3327 1221709 SGTC_2820 7989630 71.43 µM -0.454489508024134 0.329831194171889 no 2240 0.324738270925637 3250 2984098 SGTC_113 0099-0221 2.5 µM -0.454631546917137 0.329780712561656 no 2241 0.324687167591415 3352 89219 SGTC_1030 k029-0042 36.7 µM -0.45535223411725 0.32952462311184 no 2242 0.324427926666632 3238 6080581 SGTC_2152 5568786 200 µM -0.457006405922047 0.328937131066347 no 2243 0.323833220567187 3262 5399883 SGTC_2282 7944268 200 µM -0.457071100345578 0.328914162909159 no 2244 0.32380997081987 3377 2970414 SGTC_2182 6325192 200 µM -0.457417305984754 0.328791262128511 no 2245 0.323685563842916 3300 736248 SGTC_1870 st057514 26.5 µM -0.458735269563893 0.328323562987649 no 2246 0.323212141663102 3164 5393161 SGTC_338 4055-0136 114 µM -0.459521340586758 0.32804474187793 no 2247 0.32292991537353 3190 2900563 SGTC_2307 7538926 6.34 µM -0.459722021267335 0.327973575345835 no 2248 0.322857880496015 3231 96582 SGTC_934 2950-0684 338 µM -0.460128751062011 0.32782935765573 no 2249 0.322711904112663 3376 1121253 SGTC_3165 9101544 49.47 µM -0.460133425366585 0.327827700396439 no 2250 0.322710226651304 3286 5002184 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.460405380314802 0.327731285503814 no 2251 0.322612636759176 3255 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1985 st071382 65.5 µM -0.460444903844768 0.327717274370557 no 2252 0.322598454923033 3244 6123237 SGTC_1515 3460-0031 42.1 µM -0.461679088744529 0.327279876648996 no 2253 0.322155734546925 3262 2876596 SGTC_1655 st012546 55.1 µM -0.461860718034938 0.327215526843009 no 2254 0.322090602709238 3271 720985 YLR208W SEC13 SGTC_2839 9003951 25.97 µM -0.462979794767424 0.326819160254519 no 2255 0.321689425014835 3304 2990634 SGTC_2495 cafestol 54.53 µM -0.46335682810439 0.326685662518156 no 2256 0.321554309155147 3355 16667697 An anti-infammatory. SGTC_813 k007-0158 173 µM -0.463561461079209 0.326613216571028 no 2257 0.32148098557258 3255 6523916 SGTC_2819 7996655 46.38 µM -0.463922805509611 0.326485306236755 no 2258 0.321351526513671 3211 6456960 SGTC_923 1900-2434 73.3 µM -0.464230853920451 0.326376277975209 no 2259 0.321241178982423 3236 5910570 SGTC_19 0279-0214 38.434 µM -0.46653648884328 0.325560710985579 no 2260 0.320415767783942 3267 3566274 YBR002C RER2 SGTC_706 4262-0057 46.9 µM -0.469686459965494 0.324447828004853 no 2261 0.319289521474625 3228 883298 SGTC_2007 4011539 71.82 µM -0.471529418506437 0.323797437237372 no 2262 0.318631358289439 3220 45595301 SGTC_1329 1447-1697 50.6 µM -0.471632824041335 0.323760960736664 no 2263 0.318594446699984 3305 2840515 SGTC_1381 2324-0066 62.1 µM -0.472113070403609 0.323591575103439 no 2264 0.318423041790851 3294 10885928 SGTC_11 0438-0307 1.3 µM -0.472339181391535 0.323511837118262 no 2265 0.318342353886179 3324 4011476 SGTC_2743 auranofin 4.32 µM -0.473586544168396 0.323072100680567 no 2266 0.317897386359944 3232 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2164 5685496 200 µM -0.474887101167903 0.322613874705647 no 2267 0.317433722874126 3359 759046 SGTC_1141 3253-0389 52.6 µM -0.475131279615958 0.322527873180253 no 2268 0.317346702358568 3302 5402031 SGTC_2432 5630864 12.22 µM -0.477639522753145 0.321645001083119 no 2269 0.316453397793868 3356 5714970 SGTC_1244 0416-0015 52.5 µM -0.477940318443248 0.321539192015146 no 2270 0.316346341894331 3236 96201 SGTC_2219 9098279 200 µM -0.478303182021011 0.321411568970343 no 2271 0.316217215954827 3322 902349 SGTC_3091 9116372 49.47 µM -0.479573981429384 0.320964781341899 no 2272 0.315765175458597 3381 17169793 SGTC_2766 oltipraz 83.91 µM -0.480457097247946 0.32065444805373 no 2273 0.315451201408454 3350 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3274 9138298 49.47 µM -0.481559239572149 0.320267323061424 no 2274 0.315059543752705 3288 17015756 SGTC_272 doxorubicin 8.13 µM -0.483653581843588 0.319532229154764 no 2275 0.314315870557739 3324 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_547 1120-0019 610 nM -0.484266526484646 0.319317225407021 no 2276 0.314098364345655 3281 3676939 SGTC_247 mechlorethamine 29.705 µM -0.484517428245975 0.319229233640258 no 2277 0.314009349323449 3262 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2809 7964133 12.99 µM -0.485330673712721 0.318944096780117 no 2278 0.313720900186346 3260 1253665 SGTC_1080 nisoldipine 24.4 µM -0.485763588512192 0.318792353608096 no 2279 0.313567396528979 3201 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2474 5321570 43.32 µM -0.486793503944434 0.318431474827305 no 2280 0.313202337160391 3320 2841384 SGTC_216 k038-0035 28.382 µM -0.48704444107716 0.318343573407844 no 2281 0.313113418781091 3322 4444231 YPR107C YTH1 SGTC_819 1013-0258 27.7 µM -0.488088281268683 0.317978033713079 no 2282 0.312743655641498 3273 5753198 SGTC_383 2324-0395 7.37 µM -0.488146351434458 0.317957703474011 no 2283 0.312723090772252 3365 3146421 SGTC_23 0213-0011 39.996 µM -0.488844706661663 0.31771325381025 no 2284 0.312475822120326 3407 627608 SGTC_2715 st079500 56.4 µM -0.489777959094278 0.317386705624433 no 2285 0.312145514509811 3245 28246688 SGTC_3131 9127911 49.47 µM -0.489819480327885 0.317372180503683 no 2286 0.312130822335042 3445 45595681 SGTC_821 1114-0266 29.2 µM -0.490007318297137 0.317306473803041 no 2287 0.312064360117975 3326 3123235 SGTC_773 4358-1457 44.6 µM -0.49052326359639 0.317126023079819 no 2288 0.311881836024878 3374 1186886 SGTC_366 0181-0206 4.31 µM -0.491257929562835 0.316869150322392 no 2289 0.311622015633656 3451 274874 SGTC_3073 9114972 49.47 µM -0.491553234935 0.316765922944156 no 2290 0.311517604979482 3331 41905075 SGTC_2159 5658611 73.75 µM -0.492365068573501 0.316482210723964 no 2291 0.311230644362592 3389 793844 SGTC_67 0335-0847 266 µM -0.492671179935993 0.316375261734016 no 2292 0.311122472273345 3481 4552207 YOR254C SEC63 SGTC_1258 0671-0043 57.1 µM -0.49386592180711 0.315957990583292 no 2293 0.310700436566535 3308 4298767 SGTC_1191 1487-1166 10.6 µM -0.494209712421923 0.315837962939335 no 2294 0.310579040609541 3363 3955771 SGTC_1281 0884-0031 11.8 µM -0.496824377714176 0.314925740754009 no 2295 0.309656451419788 3303 1548255 SGTC_2910 7948405 25.97 µM -0.497791501766123 0.314588609393421 no 2296 0.309315503200354 3378 2971328 SGTC_426 0988-0037 14.6 µM -0.497939277261631 0.314537109693629 no 2297 0.309263421132997 3420 5383008 SGTC_867 0518-0118 155 µM -0.498162390328342 0.314459361717946 no 2298 0.30918479431656 3376 6848158 SGTC_1139 k015-0024 46.9 µM -0.498889544041878 0.31420602835097 no 2299 0.308928600239482 3372 2766652 SGTC_3246 9135460 32.98 µM -0.499124988972696 0.314124020346638 no 2300 0.308845667128945 3329 41446951 SGTC_1558 st069300 45.6 µM -0.499260479602347 0.314076831661235 no 2301 0.308797946333919 3349 24208000 SGTC_1140 3229-1848 2.98 µM -0.499569086216539 0.313969361476513 no 2302 0.308689264867908 3361 2849525 SGTC_1064 honokiol 6.76 µM -0.49985552989266 0.313869623504003 no 2303 0.308588403478445 3341 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1297 1068-0111 14.1 µM -0.499903816196337 0.313852811841404 no 2304 0.308571402522481 3267 767057 SGTC_147 4466-0538 29.23 µM -0.50266827743659 0.312890964940294 no 2305 0.307598758243662 3464 6742687 YHR072W ERG7 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.503262505874911 0.312684379257359 no 2306 0.307389861895961 3347 521171 SGTC_2038 4100038 30.985 µM -0.503460021718466 0.312615725178218 no 2307 0.307320440578644 3358 3596803 SGTC_1157 4092-0394 27.6 µM -0.503584788754307 0.312572361040726 no 2308 0.307276591998205 3470 3659885 SGTC_1606 st000094 49.2 µM -0.503800639408401 0.312497345930831 no 2309 0.307200739166159 3411 1242210 SGTC_1493 4348-0038 111 µM -0.504988637768493 0.312084617040388 no 2310 0.306783408210047 3390 800424 SGTC_1590 st077108 57.8 µM -0.505264275794217 0.311988889832566 no 2311 0.30668661531438 3369 5489485 SGTC_2155 5570423 76 µM -0.506376216329553 0.311602849434146 no 2312 0.306296283819189 3271 797402 SGTC_1010 4112-3296 15.2 µM -0.506880193387161 0.311427948231572 no 2313 0.30611944191507 3425 704384 SGTC_3342 9147791 14.508 µM -0.507030587871357 0.311375763271665 no 2314 0.306066678327752 3338 1838168 SGTC_996 3970-0799 1.8 µM -0.507457212936291 0.311227750464717 no 2315 0.305917025394727 3362 6615648 YGL040C HEM2 SGTC_1047 2043-3044 82 µM -0.507482678774011 0.311218916341372 no 2316 0.305908093429413 3284 669592 SGTC_1028 k015-0029 4.8 µM -0.507972203724745 0.311049120810088 no 2317 0.305736418401923 3336 4588309 SGTC_1830 st055982 50.3 µM -0.50813674657794 0.310992056871268 no 2318 0.305678723268159 3379 455313 An antimicrobial agent. SGTC_836 0330-0104 1.35 µM -0.508395710761686 0.310902256545177 no 2319 0.305587930108323 3354 46494820 SGTC_3194 9111903 49.47 µM -0.508674956379785 0.310805435897092 no 2320 0.305490039646427 3436 17087251 SGTC_230 MPP+ 141.667 µM -0.50876557348701 0.310774019751204 no 2321 0.305458276511786 3351 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3049 9092223 49.47 µM -0.511533136942958 0.309815195425873 no 2322 0.304488895591053 3362 8623917 SGTC_749 1000-0129 128 µM -0.513060351351881 0.309286643803512 no 2323 0.30395455249997 3439 708470 SGTC_2344 7990960 76.95 µM -0.513297970078076 0.30920444208101 no 2324 0.303871451857102 3314 140813 SGTC_839 0122-0028 230 µM -0.515693673154964 0.308376207645065 no 2325 0.303034187095331 3306 759448 SGTC_1946 st076057 65.1 µM -0.517118402858816 0.307884116592257 no 2326 0.302536753933283 3315 953009 SGTC_675 1309-0189 238 µM -0.518058453345606 0.307559619152207 no 2327 0.30220874326518 3331 4246530 SGTC_1339 1486-1321 22.7 µM -0.519879836620326 0.306931321642018 no 2328 0.301573664893328 3327 3469382 SGTC_1732 st034308 51.822 µM -0.520759510928326 0.306628075302747 no 2329 0.301267155961522 3274 830119 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.521583544554175 0.306344129763887 no 2330 0.300980161504325 3411 5024745 SGTC_52 0329-0193 875 nM -0.522071081038278 0.306176189149681 no 2331 0.300810420339959 3489 3739292 SGTC_1002 4049-0206 172 µM -0.523290568160063 0.305756293497273 no 2332 0.30038603177731 3337 4662749 SGTC_1029 k015-0030 64.7 µM -0.523708395401204 0.305612485269883 no 2333 0.300240687732296 3399 2208316 SGTC_1824 st053723 68.6 µM -0.523790372154896 0.305584273940345 no 2334 0.300212175292572 3350 675225 SGTC_546 peri-Naphthalide 147 µM -0.523854476944924 0.305562213839711 no 2335 0.300189879776416 3313 223824 A penicillin ester. SGTC_2835 9006588 71.43 µM -0.524582935916569 0.305311582042064 no 2336 0.299936575831804 3450 2345538 SGTC_2400 5203494 178.7 µM -0.524638240251708 0.305292557894024 no 2337 0.299917349041579 3390 6777674 SGTC_714 4296-0578 26.1 µM -0.525948708718643 0.304841923584216 no 2338 0.29946192235217 3336 1589775 SGTC_2899 9053889 58.44 µM -0.526021204144866 0.304817003018156 no 2339 0.29943673719417 3410 6470052 SGTC_884 0851-0618 334 µM -0.526426803671573 0.304677593415136 no 2340 0.299295848257602 3411 9642473 SGTC_2229 7354935 190 µM -0.527651858408819 0.30425669911406 no 2341 0.298870496284218 3371 318112 SGTC_1020 4335-0961 93.3 µM -0.52772840063845 0.304230409957501 no 2342 0.298843929130236 3244 669075 SGTC_1399 3562-5772 25 µM -0.529997443171427 0.303451545791215 no 2343 0.298056851765412 3359 23847490 SGTC_526 4469-0568 170 µM -0.530518253224495 0.303272899993277 no 2344 0.29787632841046 3362 2901964 SGTC_1071 trifluoperazine 6.31 µM -0.531420825745768 0.302963415236209 no 2345 0.297563596546274 3467 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2908 7930301 100 µM -0.531504186792476 0.302934838544537 no 2346 0.297534720384484 3309 2223178 SGTC_748 act1.228 77.9 µM -0.533774596652795 0.302156992149227 no 2347 0.296748745686127 3386 4421505 YNR035C ARC35 SGTC_2754 granisetron 64.02 µM -0.534066814091301 0.302056943097919 no 2348 0.296647654394913 3451 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3297 9117502 71.43 µM -0.534782629047592 0.301811926120162 no 2349 0.29640008813756 3405 7453720 SGTC_817 1391-0715 46 µM -0.535002619915842 0.301736643187423 no 2350 0.296324022817697 3345 1353946 SGTC_2564 betulinic acid 100 µM -0.537927661998914 0.300736469931495 no 2351 0.295313495130365 3525 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1717 st033143 58.0435 µM -0.537963868424162 0.300724099078251 no 2352 0.295300996672827 3478 674616 SGTC_2699 st077704 54.6 µM -0.538097249177385 0.300678528106399 no 2353 0.295254955738864 3391 645852 SGTC_1694 st024011 44.9 µM -0.538280602747034 0.30061588847104 no 2354 0.295191670369601 3453 2787533 SGTC_1425 4048-4433 7.33 µM -0.5388633147458 0.30041685392999 no 2355 0.294990585984771 3463 23734946 SGTC_3328 9140624 29.0385 µM -0.539376964871265 0.300241457954336 no 2356 0.294813386072985 3445 4904392 SGTC_1034 k072-0165 12.7 µM -0.541194053661929 0.299621349009219 no 2357 0.294186917827515 3456 5835461 SGTC_318 1488-0629 67.2 µM -0.541852808359315 0.299396682448594 no 2358 0.29395995440472 3428 3662576 SGTC_1327 1436-0082 2.18 µM -0.542214311118212 0.299273425353818 no 2359 0.29383543881255 3352 15992205 SGTC_1048 3161-0300 24.5 µM -0.542797567513767 0.299074608232184 no 2360 0.293634594109877 3438 2165101 SGTC_2915 7971052 15.16 µM -0.542844104918117 0.299058747410013 no 2361 0.293618571663775 3353 5741558 SGTC_3093 9117344 49.47 µM -0.543354863817403 0.298884696279208 no 2362 0.293442748174197 3448 24824913 SGTC_2004 4023728 41.89 µM -0.544908033396687 0.29835570619966 no 2363 0.29290838543716 3471 360084 YDR527W RBA50 SGTC_252 miconazole 1.30953 nM -0.545474175191682 0.298162991442431 no 2364 0.292713718641786 3395 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2158 5657123 3.6195 µM -0.545643621515709 0.298105322913553 no 2365 0.292655466525992 3405 2858827 SGTC_805 3852-0218 479 µM -0.545829439224687 0.298042088470521 no 2366 0.292591592460421 3332 6615355 SGTC_1845 st056753 3.01 µM -0.546887366528815 0.297682188481886 no 2367 0.292228057822923 3304 5375839 SGTC_1572 epiandrosterone 68.9 µM -0.546946872135441 0.297661950953522 no 2368 0.292207616206653 3406 441302 A steroid. SGTC_2154 5570129 200 µM -0.548308334889147 0.297199096598991 no 2369 0.291740102638267 3455 673366 SGTC_2216 7189485 200 µM -0.549431344796649 0.296817556463749 no 2370 0.291354734085391 3430 731273 SGTC_3048 9093155 49.47 µM -0.549709290448215 0.29672315966523 no 2371 0.291259391812041 3436 25236002 SGTC_1164 k060-0068 93.7 µM -0.55052485769112 0.296446253462646 no 2372 0.290979716054162 3452 5963676 SGTC_2652 actinonin 100 µM -0.551825850113731 0.296004778172694 no 2373 0.290533837356569 3398 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2987 9018338 71.43 µM -0.553340945288177 0.295491030565122 no 2374 0.290014984291203 3500 5055682 SGTC_1189 1431-2119 7.28 µM -0.555769506601648 0.294668395946771 no 2375 0.28918421688763 3484 3107275 SGTC_984 1492-0255 2.91 µM -0.557846386936742 0.293965726471954 no 2376 0.288474642024824 3412 1585198 SGTC_5 0352-0601 109.883 µM -0.55916154183172 0.293521172062278 no 2377 0.288025738585862 3395 762456 SGTC_401 neomycin 50 µM -0.559330135618397 0.293464205774713 no 2378 0.28796821611297 3412 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2756 carbadox 75.1 µM -0.562537163416262 0.292381557223787 no 2379 0.286875045293384 3405 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_632 0781-2353 4.65 µM -0.563840526544352 0.291942091098293 no 2380 0.286431334135519 3469 6811515 YHR007C ERG11 SGTC_203 k066-0004 30.888 µM -0.564179624357683 0.291827805025491 no 2381 0.286315946594872 3509 6795412 SGTC_2967 9089538 49.85 µM -0.564486517102156 0.291724390991928 no 2382 0.286211536759791 3505 728216 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.567482295425794 0.290715798044117 no 2383 0.285193275922327 3460 91467 include heat shock SGTC_1066 ketoconazole 628 nM -0.568358150294395 0.290421231126596 no 2384 0.284895900568793 3502 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2116 5511452 16.8835 µM -0.569487520135665 0.290041608603718 no 2385 0.284512668807055 3483 870744 SGTC_853 0419-0306 21 µM -0.574870951129047 0.288235245340722 no 2386 0.282689288631702 3391 762713 SGTC_1691 st019933 84.6 µM -0.576693230697098 0.287624999670315 no 2387 0.282073353056441 3469 6176082 SGTC_1808 st050063 61.5 µM -0.576899933781545 0.287555817444537 no 2388 0.282003527665836 3494 4011993 SGTC_2333 9017922 200 µM -0.578037347246612 0.287175273110162 no 2389 0.28161945241898 3492 3163164 SGTC_1410 3909-8106 77.9 µM -0.580379328279609 0.286392468369315 no 2390 0.280829421082463 3494 1039210 SGTC_1693 xanthone 101.9 µM -0.580908418966043 0.286215760702104 no 2391 0.280651088962872 3465 7020 An insecticide. SGTC_543 3844-1095 191 µM -0.582234670410197 0.28577304205358 no 2392 0.280204311570768 3467 4230703 SGTC_314 1671-0008 2.74 µM -0.582362783102536 0.285730293756116 no 2393 0.280161172208922 3424 3913060 SGTC_2793 7325131 81.82 µM -0.582492844319156 0.285686898392219 no 2394 0.280117380013099 3413 4176441 SGTC_2121 5257820 149.641 µM -0.58371550062381 0.285279108355167 no 2395 0.279705868393271 3533 791256 SGTC_790 1575-0012 79.1 µM -0.585119302487215 0.284811243477667 no 2396 0.279233750364725 3526 378741 YLR208W SEC13 SGTC_650 1328-0195 38 µM -0.585740817606564 0.284604219352818 no 2397 0.279024849978699 3496 2780821 SGTC_2275 7947463 200 µM -0.586142039960342 0.284470612016772 no 2398 0.278890033618816 3481 1225414 SGTC_1941 st076221 61.8 µM -0.586157217449972 0.28446555848988 no 2399 0.278884934390804 3470 2828568 SGTC_2018 5133068 143 µM -0.588846383880506 0.283570846007907 no 2400 0.277982163650897 3486 785362 SGTC_184 1494-0393 24.714 µM -0.594356507459227 0.281741796278457 no 2401 0.276136845761863 3464 3090647 SGTC_1772 st048439 82.2 µM -0.59510289525313 0.281494475720075 no 2402 0.275887346728955 3484 2927068 YDL195W SEC31 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.595243406275265 0.281447928176094 no 2403 0.275840389749039 3527 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_393 acivicin 6.25 µM -0.595737550745259 0.281284260831078 no 2404 0.275675284205198 3430 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1423 4048-0112 5.59 µM -0.595845105728771 0.281248643252831 no 2405 0.275639353939197 3515 X1423 SGTC_1609 st001574 46.4 µM -0.596147187693533 0.281148618364944 no 2406 0.27553845149531 3422 3960012 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.597021193056746 0.280859315940483 no 2407 0.27524661560925 3489 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2620 irigenin 100 µM -0.599545647161344 0.280024511529748 no 2408 0.274404539927889 3546 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2351 9026858 72.31 µM -0.599929567877394 0.279897659353791 no 2409 0.274276587962054 3452 1409300 SGTC_1325 1431-0015 227 µM -0.600695427844929 0.279644692978961 no 2410 0.27402143244077 3430 1103340 SGTC_2543 pimpinellin 60.67 µM -0.602679137235664 0.278989982864241 no 2411 0.273361081534512 3429 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_39 0986-0283 58.349 µM -0.603504990341034 0.278717635504977 no 2412 0.273086398357702 3581 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2243 6634756 200 µM -0.603783630734281 0.278625775522117 no 2413 0.272993751941098 3591 885676 SGTC_3311 9131146 2.8755 µM -0.604551097176447 0.27837283944841 no 2414 0.272738654114752 3481 4900406 YPR165W RHO1 SGTC_2707 st078556 66.6 µM -0.606817724495291 0.277626474674438 no 2415 0.271985942049276 3481 17250899 SGTC_35 0133-0054 64.071 µM -0.607533363173304 0.27739102932354 no 2416 0.271748504228308 3465 99677 SGTC_3345 9148410 3.559 µM -0.608754151948138 0.276989614875511 no 2417 0.271343703677648 3522 4903596 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.609166352626186 0.276854141091363 no 2418 0.271207090217217 3435 6708630 An antioxidant. SGTC_1643 st009866 20.2 µM -0.610873591860066 0.276293386000941 no 2419 0.270641634452616 3527 3156273 YOR207C RET1 SGTC_124 0136-0217 7.121 µM -0.611239364421723 0.276173317878468 no 2420 0.270520563328253 3636 3976905 SGTC_833 3852-0053 558 µM -0.611345303753889 0.276138547126418 no 2421 0.270485502345845 3585 3123681 SGTC_1931 st074438 57.1 µM -0.611537516995655 0.276075465572603 no 2422 0.270421894517077 3510 2787313 SGTC_3058 9093861 49.47 µM -0.614253347692755 0.275184926926258 no 2423 0.269523962805161 3578 17217477 SGTC_2634 4'-methoxyflavone 100 µM -0.614638551419422 0.27505873073032 no 2424 0.269396724479869 3485 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_938 3126-1755 342 µM -0.615015075973509 0.274935405464727 no 2425 0.269272382121033 3564 1777771 SGTC_2102 5377816 72.7585 µM -0.615270140154225 0.274851878300934 no 2426 0.269188166834625 3568 1379702 SGTC_589 1227-0070 34.1 µM -0.615574075456272 0.274752363397146 no 2427 0.269087832883289 3557 2841384 SGTC_2394 5221648 200 µM -0.617763114952952 0.274036150327143 no 2428 0.268365750378072 3577 788586 SGTC_3025 9087895 49.47 µM -0.618634093622814 0.273751439069316 no 2429 0.268078718243284 3550 17173641 SGTC_2667 digitoxin 100 µM -0.619158971834761 0.273579934092132 no 2430 0.267905818612192 3518 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2849 9019321 12.99 µM -0.619203996394122 0.273565224706321 no 2431 0.267890989730926 3519 16489627 SGTC_898 1000-0849 28.3 µM -0.620486950327559 0.273146252125135 no 2432 0.267468621432812 3528 6751807 SGTC_2214 7179297 48.276 µM -0.621789599289024 0.272721173349529 no 2433 0.267040113102685 3567 769744 SGTC_797 k781-0471 270 µM -0.62257540786623 0.27246490810604 no 2434 0.266781787932872 3505 23738129 SGTC_727 3032-0951 202 µM -0.62285477493387 0.272373830682251 no 2435 0.266689979790183 3503 3652836 SGTC_2096 5468907 200 µM -0.6255494072171 0.271496121489391 no 2436 0.265805266004367 3545 759785 SGTC_2954 9074818 52.69 µM -0.626598318735337 0.27115484608394 no 2437 0.265461285337739 3559 16648742 SGTC_1163 k060-0048 49.9 µM -0.62757144651332 0.270838419186726 no 2438 0.265142359333217 3558 6809982 SGTC_2822 7994718 71.43 µM -0.628330741427559 0.270591651280205 no 2439 0.264893648621113 3526 1018011 SGTC_1681 tripelennamine 100 µM -0.629461797749931 0.270224270723435 no 2440 0.264523385663584 3570 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1943 st076331 65.2 µM -0.629682141261822 0.270152729567843 no 2441 0.26445128460117 3618 24208415 SGTC_157 1348-1695 65.819 µM -0.630415212013749 0.269914784284607 no 2442 0.264211480341268 3575 5380510 SGTC_1971 st069429 63.5 µM -0.630913234059689 0.269753192634388 no 2443 0.264048629104786 3561 1246522 YGL099W LSG1 SGTC_1490 4089-0339 670 nM -0.632513418619931 0.269234313905847 no 2444 0.2635257214966 3534 742542 SGTC_3317 9138495 8.753 µM -0.633010733835596 0.269073155610808 no 2445 0.263363316758976 3579 17020139 SGTC_2314 7727897 200 µM -0.634137144865393 0.268708313736492 no 2446 0.262995661668595 3528 900724 SGTC_694 1315-0438 43.2 µM -0.634574944132112 0.268566578688942 no 2447 0.262852836943964 3514 6793154 SGTC_1833 st055984 71 µM -0.636108330608447 0.268070449923775 no 2448 0.262352908057132 3553 676288 SGTC_1644 st010134 20.9 µM -0.636335162712586 0.267997097355384 no 2449 0.26227899551549 3571 3818134 SGTC_963 1269-2853 151 µM -0.636715745381072 0.267874047905703 no 2450 0.262155007792463 3553 3668223 SGTC_3061 glucosamine 200 µM -0.637330039644351 0.267675495207807 no 2451 0.26195494396676 3532 91431 and experimental redox chemotherapeutic SGTC_1414 3917-0015 5.4 µM -0.638054012210176 0.267441587456802 no 2452 0.261719260563441 3560 6618702 SGTC_2739 tacrine 100.86 µM -0.638601660796259 0.267264716599061 no 2453 0.261541050308466 3584 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_846 0335-0850 148 µM -0.641439885558845 0.266349018432206 no 2454 0.260618462989905 3569 6819598 SGTC_734 2023-0417 80 µM -0.642478541163303 0.266014313588122 no 2455 0.260281258988563 3555 3935732 SGTC_1605 st000082 49.1 µM -0.643148579916329 0.265798507950064 no 2456 0.260063847380099 3576 1114022 SGTC_3090 9117696 49.47 µM -0.646542215012559 0.264706852851841 no 2457 0.258964133496868 3544 7923821 SGTC_1679 SEC14.276 6.7 µM -0.646650476200199 0.264672065259365 no 2458 0.258929090886468 3600 1005053 YMR079W SEC14 SGTC_2569 tetrandrine 100 µM -0.646973899140948 0.264568153541637 no 2459 0.258824418081473 3537 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_358 0075-0058 9.45 µM -0.648378672344616 0.264117058584038 no 2460 0.258370030616396 3625 1069125 SGTC_1287 0971-0001 34.6 µM -0.648577565645931 0.264053222469878 no 2461 0.2583057300759 3594 4665869 SGTC_1555 citronellol 128 µM -0.648984722844226 0.263922567211135 no 2462 0.258174125429705 3561 8842 A terpine precursor. SGTC_373 0844-0104 25.9 µM -0.649778666709343 0.26366788833807 no 2463 0.257917600482804 3600 5375804 SGTC_3262 9137218 49.47 µM -0.650298489615992 0.26350120908198 no 2464 0.257749716263136 3473 17650664 SGTC_128 0906-2981 13.371 µM -0.652732453601579 0.262721483745862 no 2465 0.256964388159474 3585 6740226 SGTC_2046 4110841 106 µM -0.653502517671056 0.262475038166803 no 2466 0.256716183425427 3610 44119630 YMR134W ERG29 SGTC_49 0717-0965 32.132 µM -0.65563244301883 0.261794009599931 no 2467 0.256030322910739 3693 5889349 YGL099W LSG1 SGTC_713 1488-1073 324 µM -0.65590141918343 0.261708070880112 no 2468 0.255943777513542 3583 3312542 SGTC_50 0929-0078 56.389 µM -0.656090293210242 0.261647733694036 no 2469 0.255883014792977 3517 1377751 SGTC_682 0kpi-0099 17 µM -0.657049574987617 0.261341394374182 no 2470 0.25557452021687 3621 1714895 YML126C ERG13 SGTC_974 1326-0144 138 µM -0.657135893525432 0.261313838244736 no 2471 0.255546770644843 3627 5411856 SGTC_2850 9015429 58.44 µM -0.657545179778593 0.26118319897228 no 2472 0.255415215256248 3591 6457570 SGTC_2545 solidagenone 89.61 µM -0.658201273884148 0.260973851633823 no 2473 0.255204403181086 3461 6708572 An anti ulcer agent SGTC_1453 4237-0541 195 µM -0.658520766664274 0.260871938720647 no 2474 0.2551017786987 3581 739892 SGTC_1042 0350-0096 82 µM -0.658610310043253 0.260843379536659 no 2475 0.255073020285092 3608 3122515 SGTC_142 0335-0849 62.6745 µM -0.658707626271402 0.260812343085069 no 2476 0.255041767408954 3642 3889043 YPR107C YTH1 SGTC_3041 9091929 49.47 µM -0.658878726715523 0.260757779705171 no 2477 0.254986823764261 3666 25236887 SGTC_1288 0973-0013 65.5 µM -0.661118781867718 0.260043975537631 no 2478 0.254268070641351 3643 4315430 SGTC_200 k038-0079 37.545 µM -0.66201023574399 0.259760190058633 no 2479 0.253982330915424 3575 3436683 SGTC_367 0335-0881 7.1 µM -0.663097928949808 0.25941415032743 no 2480 0.253633918496189 3589 23828853 SGTC_133 0724-0033 378.92 µM -0.663966441471981 0.259138012026157 no 2481 0.253355894904429 3524 280309 SGTC_1424 4048-1941 275 µM -0.665483692369737 0.258655976160459 no 2482 0.252870585292498 3670 X1424 SGTC_1789 tunicamycin 25 nM -0.665623262601896 0.258611657540929 no 2483 0.252825966787575 3611 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_533 1222-0222 6.71 µM -0.66585810397277 0.258537095748114 no 2484 0.252750900886743 3671 3982874 SGTC_1128 3448-9350 235 µM -0.666437524357841 0.25835317825341 no 2485 0.252565742191102 3602 619386 SGTC_600 1495-0418 41.6 µM -0.666710802964188 0.258266458693426 no 2486 0.252478438502141 3624 5377768 SGTC_2350 9023895 38.85 µM -0.666805086689164 0.258236543119185 no 2487 0.252448321587109 3620 2997209 SGTC_1837 st055472 66.5 µM -0.66852706045873 0.257690488880735 no 2488 0.251898607194188 3680 676091 SGTC_1346 1488-2224 62.4 µM -0.668533240368823 0.257688530252648 no 2489 0.251896635488679 3625 3722427 SGTC_1925 st057770 10.1 µM -0.669338446410033 0.257433398623219 no 2490 0.251639803516309 3562 5989122 SGTC_3149 9097855 49.47 µM -0.669391768234318 0.25741650809879 no 2491 0.251622800642933 3622 25236625 YMR079W SEC14 SGTC_3233 9132340 49.47 µM -0.669767714499356 0.257297437564222 no 2492 0.251502938872044 3589 17682950 SGTC_3253 9135987 49.47 µM -0.673077125032545 0.256250510189591 no 2493 0.250449112957328 3623 4182430 SGTC_1372 2752-0194 270 µM -0.674083192833673 0.255932682804236 no 2494 0.250129212117051 3604 823334 SGTC_409 arachidonic acid 100 µM -0.674490759476595 0.255803986788653 no 2495 0.249999679274407 3660 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_382 3229-0966 23.2 µM -0.674490759476595 0.255803986788653 no 2496 0.249999679274407 3650 5722370 SGTC_1259 0671-0132 43 µM -0.675115374231222 0.25560681976045 no 2497 0.249801233291731 3583 X1259 SGTC_2794 7785382 27.27 µM -0.67514917148234 0.255596153522802 no 2498 0.249790497972748 3623 2205081 SGTC_1012 4112-3522 18 µM -0.67560615421582 0.255451954961655 no 2499 0.249645366567346 3641 3112398 SGTC_1499 4480-0877 67.3 µM -0.676052780326994 0.255311065464505 no 2500 0.249503567571564 3576 2861909 SGTC_1885 st057546 99.9 µM -0.67810826740976 0.25466318013777 no 2501 0.248851524594403 3688 702008 SGTC_2753 fluvastatin 17.09 µM -0.678453495054807 0.254554449600772 no 2502 0.248742100289878 3643 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1090 efavirenz 20.7 µM -0.678739682302413 0.25446433246332 no 2503 0.248651409019219 3664 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_896 0964-0007 44.5 µM -0.679055466568403 0.254364914961789 no 2504 0.248551359046921 3627 6756758 SGTC_2227 7312221 64.1025 µM -0.679267071578144 0.254298307325842 no 2505 0.248484328205962 3670 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1315 1237-0019 3.69 µM -0.679889084159312 0.254102567244282 no 2506 0.248287346946288 3632 825140 SGTC_917 harmaline 728.087 nM -0.681945282269453 0.253456068623619 no 2507 0.247636775421076 3630 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3273 9137859 49.47 µM -0.682628372556499 0.253241486525283 no 2508 0.247420850482288 3707 2377234 SGTC_2508 celastrol 40.54 µM -0.682706048806 0.25321709180028 no 2509 0.24739630338163 3607 122724 Celastrol is a natural product and antioxidant. SGTC_1114 scopoletin 1.73284 µM -0.683482713826203 0.252973243128026 no 2510 0.247150934768197 3660 5280460 A coumarin with genotoxic properties. SGTC_2106 5357045 167.29 µM -0.686117390830395 0.252146957939643 no 2511 0.246319542579201 3669 668842 SGTC_2252 omeprazole 400 µM -0.686352955371439 0.252073149776283 no 2512 0.246245281495296 3595 4594 A proton pump inhibitor. SGTC_2081 5214970 32.255 µM -0.687263937752405 0.251787823899128 no 2513 0.24595820977411 3611 2063512 SGTC_3222 9128301 49.47 µM -0.687576562063466 0.251689947153192 no 2514 0.245859735991129 3682 4911358 SGTC_2586 curcumin 80 µM -0.688086819838961 0.251530238289272 no 2515 0.245699054950847 3668 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_360 0957-0399 1.01 µM -0.690782981767787 0.2506872389717 no 2516 0.244850965936948 3663 6752301 YPR165W RHO1 SGTC_485 niflumic acid 177 µM -0.69183263166574 0.250359453811858 no 2517 0.244521220762327 3672 4488 A COX2 inhibitor. SGTC_1278 0874-0585 172 µM -0.692558303168168 0.250132973678651 no 2518 0.244293392614024 3693 766306 SGTC_1435 4092-0789 56.7 µM -0.692843838966897 0.250043888522813 no 2519 0.244203778620193 3673 2248285 SGTC_1895 st058434 18.3 µM -0.693317071111801 0.249896280507599 no 2520 0.24405529609675 3673 5393175 SGTC_2438 5259590 200 µM -0.696831445039708 0.248801544649327 no 2521 0.242954142357848 3692 1201127 SGTC_2320 7373003 200 µM -0.696965681631492 0.248759780316008 no 2522 0.242912135557591 3677 5415828 SGTC_2377 9073351 62.6 µM -0.698997913123258 0.248127958991532 no 2523 0.242276667510677 3655 7337946 YHR072W ERG7 SGTC_2053 5265679 138 µM -0.699101488649087 0.248095780272682 no 2524 0.242244304138688 3654 764595 SGTC_3045 9092950 49.47 µM -0.69944484137371 0.247989123787743 no 2525 0.242137036366183 3680 44120432 SGTC_1358 1509-0022 2.48 µM -0.701171608914347 0.247453104957083 no 2526 0.241597962791126 3689 3258434 SGTC_2536 dehydroabietamide 32.04 µM -0.701314485854776 0.2474087812076 no 2527 0.241553387742085 3678 3983547 SGTC_1782 st039423 80.636 µM -0.701876151621086 0.247234580559938 no 2528 0.241378201365617 3678 2068169 SGTC_975 1335-0046 28.5 µM -0.702513890534059 0.247036865363016 no 2529 0.241179371103481 3677 16486740 SGTC_2482 5981709 142.65 µM -0.70338724373741 0.246766241078191 no 2530 0.240907226988476 3668 877755 SGTC_2329 6138490 200 µM -0.704164325831463 0.246525581648551 no 2531 0.240665222257269 3698 720019 SGTC_266 formosanin C 406 nM -0.705178489497566 0.246211688176996 no 2532 0.240349582950818 3664 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_211 3455-0679 143.504 µM -0.70728146128072 0.245561481587982 no 2533 0.23969579194099 3707 748649 SGTC_298 1391-0729 10 µM -0.708980204825196 0.245036930386736 no 2534 0.239168380517453 3666 3237558 SGTC_944 3370-0224 231 µM -0.709975077622112 0.244730005955168 no 2535 0.238859795597941 3710 4580514 SGTC_2949 9072542 2.23 µM -0.710103148887772 0.244690510217774 no 2536 0.238820086887618 3729 16457352 SGTC_1400 3771-8998 51.5 µM -0.714157232989354 0.243442051980123 no 2537 0.237564979398025 3644 670767 SGTC_2086 5274770 176.623 µM -0.714261619966405 0.243409951442605 no 2538 0.237532710016478 3728 689278 SGTC_1450 4112-4260 37.6 µM -0.714263481683918 0.243409378957726 no 2539 0.237532134521383 3681 1633175 SGTC_1974 st069448 26.9 µM -0.718389263329958 0.242142475213289 no 2540 0.23625865252619 3670 6323587 YNR016C ACC1 SGTC_2651 TUB2.036 5 µM -0.719186086051183 0.241898207425278 no 2541 0.236013135618615 3783 15992207 YFL037W TUB2 SGTC_655 k060-0012 42 µM -0.719456230438109 0.241815424413154 no 2542 0.235929930690067 3689 5994525 SGTC_2737 bleomycin 30.5 nM -0.720096965437264 0.241619139147638 no 2543 0.235732647889213 3739 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1492 4158-0558 28.5 µM -0.721688363254378 0.241131998575085 no 2544 0.235243049060616 3719 3967268 SGTC_953 1188-0045 9.7 µM -0.723239738890848 0.240657623563116 no 2545 0.234766304140102 3711 6144426 SGTC_2379 9035213 200 µM -0.723522871467802 0.240571102975759 no 2546 0.234679353859618 3712 646551 SGTC_2223 6903751 107.57 µM -0.723716024818366 0.240512088256344 no 2547 0.234620046503406 3672 5598863 SGTC_2791 5663188 71.43 µM -0.724108862493484 0.240392087713948 no 2548 0.234499452044543 3687 54690634 SGTC_344 k064-0035 6.43 µM -0.725115949921161 0.240084600675654 no 2549 0.234190450095025 3703 5088750 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.725620558712492 0.239930612633668 no 2550 0.234035707142729 3703 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2898 9056270 58.44 µM -0.726207317952699 0.239751623050458 no 2551 0.233855843230855 3662 19154699 SGTC_351 caspofungin 25 nM -0.728255921217693 0.239127272876949 no 2552 0.23322846978176 3756 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1715 st032160 10.2275 µM -0.728285813950166 0.2391181690901 no 2553 0.233219322217633 3633 5289825 SGTC_1272 0839-0021 27 µM -0.728988345944192 0.238904268574541 no 2554 0.233004395654431 3745 5027250 SGTC_265 mycophenolic acid 32.932 µM -0.729431756225122 0.238769316950681 no 2555 0.232868799190609 3804 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1887 st057648 70.8 µM -0.731851468546088 0.238033614370351 no 2556 0.232129615315106 3753 688672 SGTC_1119 parthenolide 318.541 nM -0.73231579724719 0.237892579559416 no 2557 0.231987919735776 3855 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_592 k241-0073 46.5 µM -0.732999257726315 0.237685069230653 no 2558 0.231779441059353 3720 4230158 SGTC_951 1171-0579 82.7 µM -0.733747938254109 0.237457870995748 no 2559 0.231551187891156 3710 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1402 3909-7673 35.9 µM -0.734483805373443 0.237234677405919 no 2560 0.231326963351756 3737 5328014 SGTC_2995 9067767 71.4286 µM -0.73538535977209 0.236961386860041 no 2561 0.231052417738931 3733 11673567 SGTC_1575 cyproterone acetate 48 µM -0.73679637896973 0.23653400850323 no 2562 0.230623092784273 3719 9880 An androgen receptor antagonist and liver toxin. SGTC_928 2764-0428 58.7 µM -0.737212492878939 0.236408054345578 no 2563 0.230496568692706 3776 662578 SGTC_1816 st051957 91.6 µM -0.737270894312061 0.236390379681155 no 2564 0.230478814188556 3726 674121 SGTC_2874 9043904 71.43 µM -0.739837450564655 0.235614353553252 no 2565 0.229699315887468 3720 4463428 SGTC_883 0850-0245 24.6 µM -0.741442130193315 0.235129876128573 no 2566 0.229212703846018 3819 6823229 YPR165W RHO1 SGTC_1395 3486-0190 4.35 µM -0.742291510018407 0.234873658176875 no 2567 0.228955367304186 3741 6748079 SGTC_2780 5215298 71.43 µM -0.742532348949253 0.234801036486215 no 2568 0.228882429863086 3731 2834131 SGTC_1720 st037298 9.481 µM -0.743087531328825 0.234633676116636 no 2569 0.228714344018418 3765 597396 SGTC_522 1273-0010 11.6 µM -0.744655283397166 0.234161431807975 no 2570 0.228240069098004 3798 5705015 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.745688864210855 0.233850380699534 no 2571 0.227927693811148 3793 5379071 SGTC_1422 4031-0024 15.5 µM -0.74711856729215 0.233420496190398 no 2572 0.227495996686559 3695 782427 SGTC_1916 st067606 49.2 µM -0.748886253815048 0.232889593140721 no 2573 0.226962883090234 3771 19590279 SGTC_499 genistein 192 µM -0.750232322433423 0.232485768179415 no 2574 0.226557397491175 3757 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_214 4373-3496 70 µM -0.750288342879175 0.232468970307868 no 2575 0.226540530932074 3835 3779166 SGTC_2346 9031566 143.75 µM -0.753359138924409 0.231549217625585 no 2576 0.225617064978367 3743 4771086 SGTC_2846 9008642 19.48 µM -0.754109797108361 0.231324692389898 no 2577 0.225391647524699 3807 2992898 SGTC_363 0455-0021 3.06 µM -0.754768099106588 0.231127891285715 no 2578 0.225194068982815 3771 4597466 SGTC_497 capsazepine 133 µM -0.75497309140038 0.231066627385823 no 2579 0.225132563947566 3757 2733484 A calcium channel blocker. SGTC_273 hydroxyurea 18.1 mM -0.75589927491592 0.230789941630854 no 2580 0.224854794363985 3825 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2798 7813637 45.45 µM -0.756349084689241 0.230655633365917 no 2581 0.224719963067274 3756 956368 SGTC_2260 7964312 200 µM -0.756448128843317 0.230626065735305 no 2582 0.224690280562959 3776 231951 SGTC_741 4582-0002 126 µM -0.756696635870042 0.230551888308426 no 2583 0.224615815377825 3730 2912688 SGTC_2811 7967822 32.47 µM -0.756821319881553 0.230514676118298 no 2584 0.224578459061089 3809 2232244 SGTC_68 0986-0284 82.829 µM -0.757446822579601 0.230328044271293 no 2585 0.224391106704771 3832 423278 YIL048W NEO1 SGTC_3164 9100705 49.47 µM -0.759252177931797 0.229789852791528 no 2586 0.223850859322898 3755 17174235 SGTC_2764 methyldopa 94.69 µM -0.759458939621625 0.229728260380653 no 2587 0.223789033698864 3755 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2866 9034245 58.44 µM -0.761195347733055 0.229211365347245 no 2588 0.223270198298135 3761 6462273 SGTC_228 caffeine 993.056 µM -0.762370814463593 0.228861822200497 no 2589 0.222919360053238 3760 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3018 9082602 49.47 µM -0.762499623732904 0.228823536976177 no 2590 0.222880933815042 3759 17332089 SGTC_1520 flindersine 88 µM -0.765592539288063 0.227905328034412 no 2591 0.221959392543049 3882 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1464 k208-0027 110 µM -0.766180882512777 0.227730898676963 no 2592 0.221784340953663 3763 X1464 SGTC_1698 5-fluorocytosine 1.055 µM -0.766736242378924 0.227566317042536 no 2593 0.221619175386423 3789 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2619 obliquin 87.91 µM -0.767942742716504 0.22720899997125 no 2594 0.221260601169862 3755 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2108 5365811 200 µM -0.76948562170466 0.226752522104152 no 2595 0.220802538457085 3851 780283 SGTC_3183 9108214 49.47 µM -0.769628469439883 0.226710285205686 no 2596 0.220760156119139 3724 4974831 SGTC_2549 cedrol 20.94 µM -0.76983684623118 0.226648680785147 no 2597 0.220698339934266 3717 6708665 A sedative which affects the nervous system. SGTC_2295 7971645 200 µM -0.770137192307683 0.22655990323202 no 2598 0.220609257973051 3822 2978226 YKL099C UTP11 SGTC_1436 4092-1007 8.32 µM -0.770651554856556 0.226407911398583 no 2599 0.220456747071099 3774 2881121 SGTC_138 0850-0259 40.9225 µM -0.770751164655672 0.226378483805327 no 2600 0.220427219285106 3803 6813004 SGTC_684 1140-0066 328 µM -0.770914887954411 0.226330119937987 no 2601 0.220378690967816 3808 6813534 SGTC_1945 st075991 56.6 µM -0.770981165539171 0.226310543197118 no 2602 0.22035904773705 3775 1084980 SGTC_1579 chlormadinone acetate 49.4 µM -0.771829869006042 0.226059941982348 no 2603 0.220107599268911 3805 45114258 A steroidal progestin. SGTC_3269 9137823 49.47 µM -0.772133413779637 0.225970350788443 no 2604 0.220017706926243 3725 17682936 SGTC_151 3013-0144 2.285 µM -0.772645591734491 0.225819227063498 no 2605 0.219866077308303 3776 906558 YHR107C CDC12 SGTC_2323 6148992 148.28 µM -0.775310971201727 0.225033700994166 no 2606 0.2190779639985 3787 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1343 1487-0095 224 µM -0.777719840414826 0.224325106265424 no 2607 0.218367096542523 3767 4560101 YGL055W OLE1 SGTC_43 0570-0105 72.5 µM -0.778747924697958 0.224023070321395 no 2608 0.218064109545163 3814 1114046 YDL195W SEC31 SGTC_2976 9009005 19.48 µM -0.779663318936121 0.223754335585227 no 2609 0.217794537526204 3782 2993148 SGTC_1324 1418-0026 34.4 µM -0.780129006767119 0.223617692722858 no 2610 0.217657472155572 3857 1372513 SGTC_1019 4262-0212 3.4 µM -0.782929482309598 0.222796974158636 no 2611 0.2168342617063 3847 4677213 SGTC_18 0111-0177 500 nM -0.783389791084189 0.222662238667908 no 2612 0.216699124653619 3872 721752 SGTC_2941 9056145 11.23 µM -0.783696062921924 0.222572616568396 no 2613 0.216609236624734 3681 2119517 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.783849720911252 0.222527660497728 no 2614 0.216564147513671 3832 368090 SGTC_863 0466-0191 129 µM -0.784864257849264 0.222230965078902 no 2615 0.216266580017968 3836 765160 YPR165W RHO1 SGTC_2831 7999036 19.48 µM -0.784964280492424 0.222201726268699 no 2616 0.216237255825594 3869 2988270 SGTC_3188 9110789 49.47 µM -0.785869521388389 0.221937204381519 no 2617 0.215971966057992 3806 849217 SGTC_3234 9132280 49.47 µM -0.786037738733962 0.221888069142309 no 2618 0.215922689090604 3843 17612295 SGTC_939 1165-0479 45.3 µM -0.789125371242225 0.220987295125766 no 2619 0.215019367287751 3750 1377347 SGTC_2388 9080168 200 µM -0.790271945422223 0.220653331659474 no 2620 0.214684483602891 3789 15943073 SGTC_878 0828-0289 13.7 µM -0.792025627441159 0.220143095143195 no 2621 0.21417286671192 3806 745350 YLR208W SEC13 SGTC_12 0849-0099 9.267 µM -0.79261978241506 0.219970378423335 no 2622 0.213999689743395 3724 6071388 SGTC_621 3584-0052 32.1 µM -0.794170522481092 0.219519955544922 no 2623 0.213548083320987 3807 2273927 SGTC_1878 temozolomide 1 mM -0.794746358174256 0.219352835180207 no 2624 0.213380529985722 3729 5394 DNA alkylating agent. SGTC_2477 5967686 25.23 µM -0.799447733317788 0.217991129222022 no 2625 0.212015420915369 3844 776118 SGTC_2403 6032726 181.2 µM -0.799849830690693 0.217874892447465 no 2626 0.211898903976841 3892 2881040 SGTC_2932 9016711 44.54 µM -0.800238845050882 0.217762471686593 no 2627 0.211786213800383 3832 7117328 SGTC_3038 9091290 49.47 µM -0.800479717394715 0.217692879074741 no 2628 0.211716455174898 3822 25236843 SGTC_2384 9036245 200 µM -0.801480754457192 0.217403797896955 no 2629 0.21142669065675 3806 6462766 SGTC_1570 verbenone 133 µM -0.802755006578911 0.217036138039539 no 2630 0.211058176322481 3859 29025 A natural terpanoid with antifungal properties. SGTC_2799 7812892 81.82 µM -0.802915418752301 0.216989879805171 no 2631 0.211011811739796 3839 20205235 SGTC_2059 5238311 157 µM -0.8035371253656 0.216810651433537 no 2632 0.21083217377161 3846 703021 SGTC_1212 0520-0165 585 µM -0.804051169296651 0.216662525208321 no 2633 0.210683711972807 3912 5403258 SGTC_2246 7293507 91.5585 µM -0.804779516668549 0.216452745841921 no 2634 0.210473461924087 3885 887656 SGTC_858 0438-0351 2.77 µM -0.805700293747334 0.216187710969281 no 2635 0.210207840051377 3848 2799119 SGTC_3209 9113616 49.47 µM -0.806818189358327 0.215866190544944 no 2636 0.209885619019508 3804 16649353 SGTC_607 4491-0986 66.8 µM -0.807609251584425 0.215638838911547 no 2637 0.209657779596732 3844 698981 YDR232W HEM1 SGTC_520 3584-0023 682 µM -0.80835369641887 0.215425011997477 no 2638 0.209443499680618 3864 1340790 SGTC_2460 5552655 174.22 µM -0.808850077829267 0.215282504725385 no 2639 0.209300693609889 3855 5401989 SGTC_3341 9147222 25.867 µM -0.809201358004446 0.215181687962916 no 2640 0.209199666965909 3854 1939759 SGTC_1338 1486-1223 76 µM -0.809623762365377 0.215060494987143 no 2641 0.209078223339559 3887 3444526 SGTC_222 nsc-310342 10.666 µM -0.809826964209862 0.215002208014673 no 2642 0.209019816460379 3788 432556 SGTC_1844 rapamycin 4 nM -0.810757863365132 0.214735303657995 no 2643 0.208752368365636 3787 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1088 bifonazole 369 nM -0.811369771712127 0.214559964222678 no 2644 0.208576676496899 3779 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1556 plumbagin 1.48 µM -0.813485201232791 0.213954439504545 no 2645 0.207969963809463 3758 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_775 4577-0580 57.3 µM -0.814592445784469 0.213637896676449 no 2646 0.207652817989284 3935 2006902 SGTC_3230 9131665 49.47 µM -0.815285163273857 0.213439999070312 no 2647 0.207454549704863 3775 15943720 SGTC_1203 3992-3522 103 µM -0.815316160117782 0.213431146297398 no 2648 0.207445680463425 3932 5322312 SGTC_2610 ononetin 44.17 µM -0.81581976988285 0.213287344130442 no 2649 0.207301612147533 3869 259632 SGTC_2455 5377712 9.75 µM -0.817654192342331 0.21276401581677 no 2650 0.206777336942484 3864 2243908 SGTC_1116 jasmonic acid  1.58368 µM -0.817712233157941 0.212747470041163 no 2651 0.206760761785138 3903 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3237 9133362 49.47 µM -0.819322683496303 0.212288676405851 no 2652 0.206301167023401 3795 43845137 SGTC_1988 st071872 53.4 µM -0.819379622162501 0.212272466007391 no 2653 0.206284928799422 3876 16414116 SGTC_1152 3909-8331 15.9 µM -0.819406366958732 0.212264852032333 no 2654 0.206277301766131 3825 16001939 SGTC_1063 disulfiram 1.84 µM -0.820265053098679 0.212020477555159 no 2655 0.206032512026176 3845 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2170 morpholine 200 µM -0.820548953135663 0.211939718323119 no 2656 0.205951617202801 3894 121171 Reacts with secondary amines. SGTC_1660 st012960 28.1 µM -0.821547194917453 0.211655897755234 no 2657 0.20566732659081 3868 24207266 SGTC_378 3970-0959 8.33 µM -0.822436951895595 0.211403109257203 no 2658 0.205414127945774 3896 6615653 SGTC_3011 9081274 71.4286 µM -0.822646621525361 0.211343565856617 no 2659 0.205354489103899 3866 6625322 SGTC_2402 5553605 200 µM -0.82267354575974 0.211335920442104 no 2660 0.205346831466922 3911 6758546 SGTC_3017 9080681 49.47 µM -0.824830654817539 0.210723913654656 no 2661 0.204733870138505 3896 16451914 SGTC_3266 9136860 49.47 µM -0.825232821288367 0.210609927603933 no 2662 0.204619711517947 3763 4871271 YPR165W RHO1 SGTC_2068 5226020 147 µM -0.825279823969964 0.210596607994641 no 2663 0.204606371850341 3917 1810509 SGTC_2966 9084041 48.03 µM -0.825481548111138 0.210539449066272 no 2664 0.204549127099256 3814 17741380 SGTC_1086 cerivastatin 2.18 µM -0.827105572521347 0.210079610387552 no 2665 0.204088613005967 3809 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_969 1313-0238 134 µM -0.827959046577096 0.20983818793197 no 2666 0.203846846661782 3886 5212874 SGTC_2778 tioconazole 65.09 nM -0.829747679009749 0.209332766305471 no 2667 0.203340729048651 3800 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3190 9110366 49.47 µM -0.831003849465791 0.208978233436085 no 2668 0.202985727361254 3846 17123768 SGTC_116 0155-0182 31.788 µM -0.833767126895196 0.208199590924163 no 2669 0.202206111512119 3815 771486 SGTC_2541 muurolladie-3-one 83.07 µM -0.835381064962694 0.207745604856497 no 2670 0.201751593770149 3922 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3321 9137793 26.8275 µM -0.836387995033306 0.20746266106369 no 2671 0.201468332007258 3852 4904192 SGTC_3080 9117754 49.47 µM -0.836625224710356 0.207396033531428 no 2672 0.201401631097976 3891 9550191 SGTC_933 2914-0560 114 µM -0.837924862817337 0.207031246067373 no 2673 0.201036452033186 3945 463887 SGTC_173 1273-0061 2.693 µM -0.839103629723861 0.206700713744326 no 2674 0.200705579714897 3890 2847414 YPL266W DIM1 SGTC_3150 9097574 49.47 µM -0.839780406061517 0.206511083450571 no 2675 0.200515760739667 3888 17217476 SGTC_10 0279-0212 42.575 µM -0.839805542255883 0.206504042364869 no 2676 0.200508712737747 3861 39851 YBR002C RER2 SGTC_2969 9091408 28.7 µM -0.841023692860469 0.206162987647511 no 2677 0.200167330707448 3845 4286311 SGTC_1489 4065-0444 182 µM -0.84229802510655 0.20580656098101 no 2678 0.199810578109667 3840 2877968 SGTC_521 r062-0005 13.8 µM -0.84406488431466 0.205312981466712 no 2679 0.199316574543033 3801 2832033 SGTC_317 4495-0002 170 µM -0.844510853853263 0.205188509240802 no 2680 0.199192000394139 3930 15991618 SGTC_1062 mesoridazine 14.2 µM -0.84521321336532 0.204992568291531 no 2681 0.19899590310066 3901 4078 A neuroleptic. SGTC_810 3825-7150 143 µM -0.847732510308966 0.204290662276225 no 2682 0.198293478272097 3935 22330411 YGL099W LSG1 SGTC_2851 9015922 71.43 µM -0.847956069349786 0.204228445278144 no 2683 0.198231218404387 3899 2996893 SGTC_950 1165-0508 94.1 µM -0.848265083391943 0.204142464535861 no 2684 0.19814517925565 3925 6148369 SGTC_1009 4106-0057 9.87 µM -0.84938916272736 0.203829880155543 no 2685 0.197832390731426 3844 2928005 SGTC_319 1348-1596 45.5 µM -0.849674296950925 0.203750635313694 no 2686 0.197753096180221 3991 5380505 SGTC_1987 st072290 61.9 µM -0.849878498266111 0.203693894730161 no 2687 0.197696320512444 3929 54697379 SGTC_3263 9137018 49.47 µM -0.850254888431414 0.203589333425709 no 2688 0.197591695666888 3923 43844957 SGTC_1506 4226-2149 212 µM -0.851926839428361 0.20312525196356 no 2689 0.197127349608133 3928 991114 SGTC_1416 3966-0321 25.3 µM -0.852565860378758 0.202948046623412 no 2690 0.196950050748405 3919 582530 YLR208W SEC13 SGTC_455 paf C-16 10 µM -0.85263964853901 0.202927590556668 no 2691 0.196929584153774 3884 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1597 7-benzyloxygramine 47.5 µM -0.852889617732496 0.202858301512043 no 2692 0.196860259860953 3873 260807 SGTC_3069 9117009 49.47 µM -0.852973954552233 0.202834927349548 no 2693 0.196836873951268 3859 41904981 SGTC_181 1447-1644 8.07 µM -0.85303444247294 0.202818163960474 no 2694 0.196820102181991 3912 534600 SGTC_2843 9000894 45.46 µM -0.853582704746705 0.202666258422033 no 2695 0.196668122403355 3827 2242070 SGTC_217 ketoconazole 989 nM -0.854500150785832 0.202412216279982 no 2696 0.19641396294918 3798 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3336 9143619 71.43 µM -0.855059375700252 0.202257459540253 no 2697 0.196259138949618 3905 45595730 SGTC_327 1273-0057 3.96 µM -0.856869526747136 0.20175701413335 no 2698 0.195758497872443 3809 3108138 SGTC_2689 tacrolimus 100 µM -0.859296796438099 0.201087121422138 no 2699 0.19508839558629 3929 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.86104980404354 0.200604146354312 no 2700 0.19460530673024 3907 390807 SGTC_1882 5615643 20 µM -0.863264971828938 0.19999483764893 no 2701 0.193995899236889 3843 2253075 SGTC_3128 9127691 49.47 µM -0.864380527210079 0.19968841238352 no 2702 0.193689443220612 3969 41316314 SGTC_1022 4477-0945 21.3 µM -0.865866334721861 0.199280723716724 no 2703 0.193281733337499 3868 4648966 SGTC_2746 daunorubicin 9.88 µM -0.867035596244262 0.198960244381029 no 2704 0.192961253147145 3811 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_762 1165-0429 115 µM -0.869093433891189 0.198396972812561 no 2705 0.192398013923504 3896 5967793 SGTC_2870 9038528 12.99 µM -0.869496737073299 0.198286693493812 no 2706 0.192287745998702 3993 6463316 SGTC_1553 gossypol 38.6 µM -0.869510833930583 0.198282839515091 no 2707 0.192283892448187 3791 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3228 9131799 49.47 µM -0.871098202963971 0.197849153544146 no 2708 0.191850267627129 3943 17015818 SGTC_3213 9129884 49.47 µM -0.87132337199856 0.197787681431762 no 2709 0.191788806264149 3935 17190742 SGTC_2720 fluspirilene 36.88 µM -0.871535583008001 0.197729757480485 no 2710 0.191730892915395 3929 3396 An atypical antipsychotic. SGTC_1955 wogonin 32.4 µM -0.871787395164 0.197661037518579 no 2711 0.191662186128324 4023 5281703 A flavanone. SGTC_2999 9069765 71.4286 µM -0.871848305037443 0.197644417279786 no 2712 0.19164556917312 3938 2097066 SGTC_1642 st009582 77.7 µM -0.872541584642311 0.197455304315054 no 2713 0.191456496238298 3885 6739311 SGTC_1267 0828-0272 9.49 µM -0.873682714743551 0.197144264961748 no 2714 0.191145533401826 4019 745334 SGTC_1618 st003135 44.5 µM -0.87430149286593 0.196975727822388 no 2715 0.190977043279404 3840 1270615 SGTC_1121 fusaric acid 630.51 nM -0.87473919392998 0.19685656348309 no 2716 0.190857914543272 3922 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2349 9023730 187.07 µM -0.87782479768236 0.196017745388822 no 2717 0.190019402512098 3954 4126287 SGTC_2327 6189656 200 µM -0.877851943295099 0.19601037551727 no 2718 0.190012035760829 4023 5349088 SGTC_2681 menadione 3.18 µM -0.878581177550373 0.195812455692639 no 2719 0.189814202547964 3958 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_60 0986-0278 202 µM -0.880180011091704 0.195378944558671 no 2720 0.189380900119418 3885 3110598 SGTC_957 1187-1561 14.1 µM -0.881144990840109 0.195117580253264 no 2721 0.18911967427099 3898 1538454 SGTC_1645 Cervolide 78 µM -0.882328563235349 0.194797300570698 no 2722 0.188799577237541 3926 23173 A fragrance. SGTC_1968 st069590 43.6 µM -0.882638140466526 0.194713580454739 no 2723 0.188715907225931 3959 6384066 SGTC_2680 butyl paraben 22.24 µM -0.883613063220689 0.194450071534233 no 2724 0.188452562403553 4000 7184 An antifungal and steroid mimetic. SGTC_3195 9113082 49.47 µM -0.88374973785815 0.194413147516945 no 2725 0.18841566215636 3861 17018038 SGTC_1741 st038134 10.228 µM -0.885742238177731 0.193875338485624 no 2726 0.187878221003874 4014 1272587 SGTC_794 k038-0031 316 µM -0.887150929353069 0.193495656992285 no 2727 0.187498823687553 3941 6624242 SGTC_45 0kpi-0036 14.9 µM -0.887607328312974 0.193372742111677 no 2728 0.187376005152053 3991 2795021 SGTC_256 clotrimazole 625 nM -0.887723987729599 0.193341331680096 no 2729 0.187344619682675 3886 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_461 N-acetylfarnesylcysteine 136 µM -0.88900201984827 0.192997426723732 no 2730 0.187000997136385 3994 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1000 4048-0884 8.67 µM -0.889426381168422 0.192883318232236 no 2731 0.18688698603998 4001 13040088 SGTC_51 1013-0126 23.419 µM -0.889555712081252 0.192848550035913 no 2732 0.186852247885307 3947 1627850 SGTC_3042 9091578 49.47 µM -0.890171189645704 0.192683142874467 no 2733 0.186686985987173 3913 25236497 SGTC_1815 st051655 58.2 µM -0.890640157149881 0.192557167926581 no 2734 0.186561124271216 3904 5984156 SGTC_2686 alizarin 95.37 µM -0.891919787429185 0.192213687375608 no 2735 0.186217963887406 3977 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1944 st076371 56.9 µM -0.89214190524845 0.192154104327551 no 2736 0.186158438082796 3950 24208455 SGTC_1201 1889-3372 45.9 µM -0.892369576100448 0.192093043408261 no 2737 0.18609743635018 3832 5392199 SGTC_1529 apigenin 74 µM -0.893011894405614 0.191920838783666 no 2738 0.185925401500251 3964 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2325 6158266 200 µM -0.893111750588178 0.191894075972607 no 2739 0.185898665453144 3995 3623240 SGTC_513 4245-1575 41.7 µM -0.894633366436046 0.191486544978836 no 2740 0.185491554614586 3879 719745 SGTC_392 N-ethylmaleimide 8.33 µM -0.894728827980651 0.191460995414961 no 2741 0.185466032180691 3899 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_407 eburnamonine 100 µM -0.896624440362484 0.190954081675789 no 2742 0.184959675996672 3821 3195 SGTC_1877 wortmannin 25 µM -0.896739949901433 0.19092321941438 no 2743 0.184928848868041 3975 312145 A covalent inhibitor of PI 3-kinase. SGTC_348 k064-0012 10.7 µM -0.897575766355362 0.190699994100686 no 2744 0.184705881732537 3870 5066323 SGTC_1812 st052057 4.327 µM -0.898016094864755 0.190582458005767 no 2745 0.18458848445009 3984 3645418 SGTC_3152 9099253 49.47 µM -0.900739761046397 0.189856423439554 no 2746 0.183863351373657 3908 25236131 SGTC_2427 5545055 42.75 µM -0.900779836750477 0.189845753363555 no 2747 0.183852695112446 3946 5372858 SGTC_874 0599-0792 117 µM -0.902070320621918 0.189502361743367 no 2748 0.183509756866935 3971 765305 SGTC_1332 1480-0653 17.5 µM -0.903052186287579 0.189241348156025 no 2749 0.183249099296941 3978 5749438 SGTC_2226 7298446 200 µM -0.903072725614028 0.189235890462838 no 2750 0.183243649153221 3947 3283010 SGTC_2876 9059903 25.97 µM -0.905925584560606 0.188478772862881 no 2751 0.182487620743897 3914 6916095 SGTC_59 0330-0160 1.33 µM -0.906035597309098 0.188449614137991 no 2752 0.182458505633251 3929 4293482 SGTC_4 0960-0234 25.671 µM -0.907591096830238 0.188037628987605 no 2753 0.182047149956359 3977 6821112 SGTC_42 0133-0086 60.653 µM -0.909073442407848 0.187645536978166 no 2754 0.181655680045392 3871 162923 Model of phenazepam hydroxylation. SGTC_2014 4013930 200 µM -0.910556460874286 0.187253772838163 no 2755 0.181264559965694 3916 64556 SGTC_3307 9126885 69.2785 µM -0.911777520797702 0.186931589356362 no 2756 0.180942923035345 3969 24824909 SGTC_1205 4161-2785 76 µM -0.911839954646391 0.186915125059156 no 2757 0.180926487078015 4078 3498106 SGTC_1167 k781-0610 148 µM -0.912737801629001 0.186678454989777 no 2758 0.180690228796834 4000 4525169 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.915371519853295 0.185985284831067 no 2759 0.179998312245306 3972 15053 SGTC_2162 5663267 200 µM -0.918000654176825 0.185294915019238 no 2760 0.179309261687963 3955 6456493 SGTC_354 2783-3500 4.88 µM -0.918501213716663 0.185163656402786 no 2761 0.179178261909942 4002 6740761 SGTC_3185 9108267 49.47 µM -0.921721605934067 0.184320574549371 no 2762 0.178336903841012 3995 4910486 SGTC_3123 9126162 49.47 µM -0.922589170972002 0.184093859592975 no 2763 0.178110670564796 4070 25239884 SGTC_2770 toltrazuril 17.5 µM -0.922800521595049 0.184038655058529 no 2764 0.178055584484844 3909 68591 Kills coccidiodes. SGTC_1960 st011366 51.8 µM -0.923784739327994 0.18378171431557 no 2765 0.177799201088526 4009 3972846 SGTC_610 4215-0184 155 µM -0.924071227476451 0.183706965477757 no 2766 0.177724616255515 4021 5605015 SGTC_1654 st012436 41.8 µM -0.924187666035494 0.183676590413956 no 2767 0.177694308077026 3937 4323132 SGTC_2879 9041815 71.43 µM -0.925014003851851 0.183461115450455 no 2768 0.17747931157051 4009 4942971 SGTC_2723 salbutamol 83.58 µM -0.93211602577493 0.181615702108358 no 2769 0.175638283397387 4025 9884233 β2-adrenoceptor agonist SGTC_2172 5754775 163.918 µM -0.932828286928906 0.181431268857834 no 2770 0.175454316849466 3976 2263357 SGTC_2833 9001315 45.46 µM -0.933095020554634 0.181362230910044 no 2771 0.175385454935904 3990 2989378 SGTC_893 0958-0369 48.9 µM -0.933095978591837 0.181361982973498 no 2772 0.175385207632862 3972 6819948 SGTC_998 3996-0085 177 µM -0.934056469578715 0.181113518165574 no 2773 0.175137382403566 4036 715391 SGTC_2391 6285546 200 µM -0.935450079535409 0.180753391250623 no 2774 0.174778199275274 3993 846083 SGTC_3278 9139605 49.47 µM -0.93723519534339 0.180292750458885 no 2775 0.174318794698084 4062 7958859 SGTC_2623 humulene 100 µM -0.939422131166783 0.179729426935118 no 2776 0.173757027358039 4039 6187145 An anti-inflammatory. SGTC_570 0987-0065 62.6 µM -0.93948985350345 0.17971200029616 no 2777 0.17373964964114 3800 3104428 SGTC_3215 9129942 49.47 µM -0.941131345614246 0.179289928378177 no 2778 0.173318776957914 4000 17682944 SGTC_862 0452-0056 10.2 µM -0.941241691423523 0.179261577871248 no 2779 0.173290507992039 3977 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2168 5727979 200 µM -0.941567715516105 0.179177830869046 no 2780 0.173207002588676 3909 695210 SGTC_3155 9099265 49.47 µM -0.942065077553875 0.179050119077949 no 2781 0.173079661323447 4055 25236499 SGTC_859 0439-0102 54.6 µM -0.944444238591819 0.178439994629413 no 2782 0.172471341988976 4026 610143 SGTC_486 niguldipine 82 µM -0.945212149695088 0.178243347425404 no 2783 0.172275288939847 4066 1236 A calcium channel blocker. SGTC_3166 9102297 49.47 µM -0.945542510409513 0.178158790459578 no 2784 0.172190989312055 4034 25237072 SGTC_1709 st033179 39.1045 µM -0.945587972265069 0.178147156320123 no 2785 0.172179390666962 3991 573381 SGTC_1122 capsaicin 818.572 nM -0.945700996987125 0.178118234248834 no 2786 0.172150556925062 4098 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2435 5706476 10.6 µM -0.946336551019479 0.177955656466669 no 2787 0.171988478096161 4021 5725375 SGTC_2519 cryptotanshinone 88.04 µM -0.947377342687773 0.177689619117187 no 2788 0.171723266138825 4015 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2486 5283202 22.39 µM -0.947992564969662 0.177532479870485 no 2789 0.171566619632331 4082 1377751 SGTC_595 3909-8003 73.7 µM -0.949288276622345 0.177201817933419 no 2790 0.171237007206269 4094 699517 SGTC_1638 st008370 60.6 µM -0.949659078459601 0.177107261989413 no 2791 0.171142754539309 3983 24207134 SGTC_359 0081-0058 15.9 µM -0.950164932482606 0.176978318612374 no 2792 0.17101422700036 4119 3494159 SGTC_1903 st060211 78.3 µM -0.952182531680105 0.176464618181845 no 2793 0.170502209254769 4079 688960 SGTC_1637 st007924 17.4 µM -0.952959334732902 0.176267088282586 no 2794 0.17030533748144 3975 683336 SGTC_2492 derrusnin 100 µM -0.953151146488442 0.176218334847344 no 2795 0.170256747431703 3974 1715307 Part of coumarin class of compounds. SGTC_3281 9140613 49.47 µM -0.953498153987569 0.17613015647869 no 2796 0.170168865527721 4049 16013766 SGTC_2882 9058044 58.44 µM -0.954036892567851 0.175993312515927 no 2797 0.170032484087693 4059 18076804 SGTC_1659 st012954 42.1 µM -0.954181396588019 0.175956618777678 no 2798 0.169995914876387 4020 24207262 SGTC_496 calpeptin 138 µM -0.954632089540028 0.17584220595899 no 2799 0.169881891709947 4063 73364 A calpain inhibitor. SGTC_806 3966-4455 5.86 µM -0.956567395400209 0.175351445374296 no 2800 0.169392826086578 4020 714982 SGTC_3351 9150312 21.596 µM -0.95679234707471 0.175294457852317 no 2801 0.169336037868401 3954 4904905 SGTC_1429 4049-0205 9.46 µM -0.958705969941379 0.17481015036067 no 2802 0.168853445064439 4069 22774478 SGTC_1821 st053465 65.6 µM -0.962683453833011 0.173806232695679 no 2803 0.167853201352126 4047 675086 SGTC_3203 9113543 49.47 µM -0.962870747678013 0.173759050273144 no 2804 0.167806195583024 4139 17018012 SGTC_535 2293-4129 48.2 µM -0.963719461039987 0.173545347439199 no 2805 0.167593297355496 4062 396118 YIL048W NEO1 SGTC_1797 st048695 56.8 µM -0.963721328683524 0.173544877358091 no 2806 0.167592829052393 4027 592262 YIL048W NEO1 SGTC_2222 6885208 172.143 µM -0.964187992857779 0.173427444574416 no 2807 0.167475841556289 3989 609514 SGTC_2069 5228469 200 µM -0.967723759996765 0.172539337500602 no 2808 0.166591174274482 4066 2835210 SGTC_1795 st049545 62.3 µM -0.967932617008379 0.172486968078648 no 2809 0.166539011681508 3970 5291882 SGTC_940 3232-1287 54.8 µM -0.970280912621711 0.171898847418411 no 2810 0.165953244408831 3970 1585493 YIL048W NEO1 SGTC_2635 hydroquinidine 100 µM -0.97344414693982 0.171108655449952 no 2811 0.165166303346327 3980 442912 An experimental heart treatment. SGTC_2638 epoxomicin 18 µM -0.973487674452016 0.171097798285531 no 2812 0.165155491561471 4044 9915668 A protesome inhibitor. SGTC_2462 5162487 171.77 µM -0.973677155019666 0.171050540858887 no 2813 0.165108431881564 3950 2259986 SGTC_1231 0242-0792 125 µM -0.97514327706558 0.170685164756249 no 2814 0.164744597067306 4043 3707635 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.978310457485485 0.169897570175151 no 2815 0.163960399667155 4041 6312947 SGTC_1290 0986-0249 10.2 µM -0.978474424703311 0.169856859370252 no 2816 0.163919867249134 3941 53329 SGTC_107 0358-0022 2.6945 µM -0.979377407681711 0.169632773201192 no 2817 0.163696767897813 4087 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2217 6934799 96.0675 µM -0.980017678260467 0.169473997257231 no 2818 0.163538696203028 4034 675606 SGTC_2160 5660466 132.927 µM -0.980419632019923 0.169374368473015 no 2819 0.163439511458609 3947 2859134 SGTC_511 blebbistatin 171 µM -0.980734597436587 0.169296327006707 no 2820 0.163361818970691 4134 3476986 A myosin inhibitor. SGTC_2074 5212007 75.395 µM -0.981418618612403 0.16912692119516 no 2821 0.163193174177665 3920 758611 SGTC_376 3970-0862 59.1 µM -0.981436924737844 0.169122388966039 no 2822 0.163188662374183 4107 3135186 SGTC_3320 9137005 35.139 µM -0.981845375383685 0.169021285070539 no 2823 0.163088015018254 4077 4908713 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.983031402622429 0.168727927507902 no 2824 0.162795991769869 4077 688751 SGTC_2485 5633444 17.78 µM -0.983507508001051 0.168610257457885 no 2825 0.162678860968707 4086 5724239 SGTC_1664 st014217 9.02 µM -0.984353825465581 0.16840121927878 no 2826 0.162470786460067 4113 3982782 SGTC_270 tamoxifen 5.46 µM -0.98519818917852 0.168192829828732 no 2827 0.162263364968358 4109 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2516 gossypol 71.55 µM -0.985399576279773 0.16814315189008 no 2828 0.162213918855107 4113 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1966 st070145 16.1 µM -0.985673136294981 0.168075685543847 no 2829 0.162146768007616 4028 3748532 SGTC_3060 1327-0027 12.5 µM -0.985926242486768 0.168013279109601 no 2830 0.162084654089756 3977 16000455 YPR107C YTH1 SGTC_1716 st033144 30.6155 µM -0.990207212865093 0.166960013112516 no 2831 0.161036423880274 4094 674617 SGTC_2703 st077852 53.4 µM -0.992755442028451 0.166335087376678 no 2832 0.160414574566833 4128 6281836 SGTC_2371 9071574 200 µM -0.99389936817203 0.166055043691746 no 2833 0.1601359310049 4097 45596039 SGTC_2137 5261020 140 µM -0.994896426332061 0.165811203273612 no 2834 0.159893320576736 4043 763655 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.99517234017461 0.165743766728978 no 2835 0.15982622598725 4039 688761 SGTC_169 k015-0017 16.025 µM -0.995534462990002 0.165655286623453 no 2836 0.159738195720732 4038 1840002 SGTC_2127 5253358 187.912 µM -0.996479994767835 0.165424401979365 no 2837 0.159508491206186 3991 20612 SGTC_1404 3909-7820 48.3 µM -0.996843412874883 0.165335716153985 no 2838 0.159420261106391 4060 23741373 SGTC_1151 3909-8316 15.3 µM -0.999354937217883 0.164723663766275 no 2839 0.158811390582937 4128 800431 SGTC_3197 9113331 49.47 µM -0.999608919459987 0.164661850739435 no 2840 0.158749902477053 4121 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2673 kobusone 100 µM -0.999704919394503 0.164638490632504 no 2841 0.158726665333866 4149 6710676 An epoxy ketone and protein crosslinker. SGTC_2982 9019404 25.97 µM -1.00011314603091 0.164539178943742 no 2842 0.158627877453239 4032 22333232 SGTC_137 0438-0332 85.389 µM -1.00394386433707 0.163609149638558 no 2843 0.157702836029835 4059 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3116 9124943 49.47 µM -1.00419218748955 0.163548979285676 no 2844 0.157642993530567 4077 41905195 YPL160W CDC60 SGTC_84 0443-0269 128.823 µM -1.00508185397957 0.163333525153127 no 2845 0.157428718504686 3992 6150058 SGTC_733 4069-0007 56.1 µM -1.00667684526378 0.16294772149412 no 2846 0.157045046364688 4092 5717425 YNL287W SEC21 SGTC_1571 st070080 73.4 µM -1.00723962012599 0.162811736500433 no 2847 0.156909818845869 4141 4315245 SGTC_1008 4106-0037 6 µM -1.00981926154354 0.162189354695075 no 2848 0.156290945068666 4042 2905394 SGTC_1731 st035964 63 µM -1.01472135516495 0.16101091710428 no 2849 0.155119335753828 4046 6739575 SGTC_155 k072-0202 43.6 µM -1.01571006481104 0.160773915391998 no 2850 0.154883736872324 4022 5857737 SGTC_2133 5320837 200 µM -1.01772897466068 0.160290674167748 no 2851 0.154403386803595 4148 2841355 SGTC_1901 st060216 58.6 µM -1.01875678804393 0.160045024361326 no 2852 0.15415922257145 4071 688792 SGTC_3029 9088683 49.47 µM -1.02256666273198 0.159136603976165 no 2853 0.153256389306656 4154 25236615 SGTC_676 falcarinol 140 µM -1.02400707512473 0.15879403598548 no 2854 0.152915966566655 4129 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_847 0342-0274 5.54 µM -1.02653801873579 0.15819328271372 no 2855 0.152319026293334 4116 18097 SGTC_1767 st044992 70.3 µM -1.03075994107179 0.157194476669289 no 2856 0.151326703966061 4160 9600693 SGTC_3114 9122766 49.47 µM -1.0314055554431 0.157042106062757 no 2857 0.151175338377319 4126 17176985 SGTC_2193 5925765 200 µM -1.03333800088807 0.156586612887497 no 2858 0.150722874793286 4123 877370 SGTC_1872 amphotericin b 148 nM -1.03439067730458 0.156338854762864 no 2859 0.15047678046708 4144 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2722 naftopidil 47.16 µM -1.03839271019982 0.155399293526442 no 2860 0.149543631008313 4038 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1357 1503-1303 39.5 µM -1.04179066264657 0.154604483654163 no 2861 0.148754372067423 4088 292895 SGTC_587 k089-0003 57 µM -1.04457561987278 0.153955065368473 no 2862 0.148109576216941 4010 9659696 SGTC_971 1315-0384 26.7 µM -1.04646964995365 0.153514433243986 no 2863 0.147672125152662 4178 6769120 SGTC_2040 5100729 123 µM -1.04815504512706 0.153123041455052 no 2864 0.147283589381288 4164 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3100 9120536 49.47 µM -1.05167674793427 0.152307348739726 no 2865 0.146473941265399 3970 16421196 SGTC_1792 st045773 43.6 µM -1.05230300045934 0.152162599489614 no 2866 0.146330277758813 4104 2919270 SGTC_2788 5282734 71.43 µM -1.05259823647993 0.152094391628958 no 2867 0.146262582887479 4241 743706 SGTC_3112 9123419 49.47 µM -1.05287061241067 0.152031483104692 no 2868 0.146200148275965 4187 17015854 SGTC_2491 paeonol 100 µM -1.05314762779273 0.151967520771285 no 2869 0.146136668561401 4053 11092 Increases levels of cortical cytochrome oxidase. SGTC_2077 5212015 200 µM -1.0550265167818 0.151534160659858 no 2870 0.14570659871756 3998 780900 SGTC_1236 0330-0013 258 µM -1.06035894014574 0.150308731780476 no 2871 0.144490667213238 4167 4617066 SGTC_553 k007-0256 45.7 µM -1.06151398218205 0.150044167458226 no 2872 0.144228191015186 4202 6287000 SGTC_3319 9138450 16.7555 µM -1.06227434400044 0.149870174869194 no 2873 0.144055579022308 4085 2029690 SGTC_2021 4019055 173 µM -1.06319487603729 0.149659710879252 no 2874 0.143846792804011 4025 44827708 YER133W GLC7 SGTC_1115 galangin 695.678 nM -1.06752526944025 0.14867228692566 no 2875 0.14286735454519 4226 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3175 9106517 49.47 µM -1.06754247211841 0.148668373045208 no 2876 0.142863472693565 4173 41468073 SGTC_1182 1222-0449 220 µM -1.07152927053787 0.147763171043345 no 2877 0.141965758400308 4161 658318 SGTC_491 tetrandrine 80.3 µM -1.07216076683535 0.147620129214834 no 2878 0.141823914426722 4181 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_835 0312-0010 67.2 µM -1.07317051581509 0.147391601192898 no 2879 0.141597308449026 4149 1626196 SGTC_1568 digitonin 820 nM -1.07735693159619 0.146446654832493 no 2880 0.140660418553625 4175 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_872 0588-0139 234 µM -1.07775869550434 0.146356184133562 no 2881 0.140570728428965 4134 2047100 SGTC_1674 st016616 23.6 µM -1.07875539374811 0.146131905950076 no 2882 0.140348392283304 4117 625830 SGTC_2593 nobiletin 86.24 µM -1.0826513895307 0.145257440311523 no 2883 0.139481594038359 4179 72344 An anti-infammatory. SGTC_345 1362-0200 395 µM -1.087478157854 0.144178952971862 no 2884 0.138412773203885 4169 1419823 SGTC_297 0986-0032 24 µM -1.08922995500853 0.143788872138069 no 2885 0.138026246212991 4120 2847425 SGTC_2701 st077767 14.721 µM -1.08969113988942 0.143686296468285 no 2886 0.137924610159237 4151 5721188 SGTC_2677 mitomycin C 100 µM -1.09031602821615 0.14354738906032 no 2887 0.13778697856344 4228 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_196 k015-0023 18.111 µM -1.09058138701897 0.143488429463197 no 2888 0.137728561667707 4121 5211998 SGTC_2437 5741531 144.16 µM -1.09105820970718 0.143382526170149 no 2889 0.137623634942507 4207 2262990 SGTC_158 k038-0087 26.446 µM -1.09140608879804 0.143305294820257 no 2890 0.137547117199758 4100 X158 SGTC_1361 1608-0041 5.61 µM -1.09172963105091 0.143233491619862 no 2891 0.137475978535628 4148 X1361 SGTC_1509 1326-1131 80 µM -1.09240342503507 0.143084035635002 no 2892 0.137327909114967 4148 768313 SGTC_778 3456-2434 196 µM -1.09405889903941 0.142717278232537 no 2893 0.13696457350354 4142 5539063 SGTC_2684 capsaicin 100 µM -1.09464374047697 0.142587863213576 no 2894 0.136836372441634 4197 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_577 r071-0003 38.6 µM -1.09613323890299 0.142258622193408 no 2895 0.13651023521642 4187 4568517 YMR134W ERG29 SGTC_202 3594-0513 34.79 µM -1.10108192193201 0.14116845347606 no 2896 0.135430502142818 4228 708429 SGTC_1989 st071868 50.2 µM -1.10190243089518 0.140988248605594 no 2897 0.1352520458345 4189 16414057 SGTC_763 3453-1109 128 µM -1.10205494815018 0.14095476909799 no 2898 0.135218891923514 4210 1560353 SGTC_1891 st059073 26.2 µM -1.10403219383607 0.140521226239787 no 2899 0.134789586319122 4276 688754 SGTC_1961 st076550 68.7 µM -1.10631258213471 0.140022339646042 no 2900 0.134295623857811 4226 1579337 SGTC_105 0111-0055 734.78 µM -1.10689821237364 0.139894414226334 no 2901 0.134168969432611 4208 5179370 SGTC_2827 7993847 71.43 µM -1.10893848817968 0.139449355725458 no 2902 0.133728359381008 4283 2985692 SGTC_315 k915-0449 187 µM -1.10943586612718 0.139341005644434 no 2903 0.133621098547222 4211 20970215 YNL149C PGA2 SGTC_987 1497-1013 404 µM -1.10990518505328 0.139238820546278 no 2904 0.133519942971886 4219 1676435 SGTC_3186 9110464 49.47 µM -1.112086818253 0.138764481776142 no 2905 0.133050411887024 4213 17018021 SGTC_3244 9134489 49.47 µM -1.1128687027545 0.138594749765747 no 2906 0.132882411695002 4210 16584271 SGTC_441 propafenone 146 µM -1.11323574500963 0.138515120792229 no 2907 0.132803597287254 4185 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_926 2268-1401 59.4 µM -1.11721687865533 0.137653425829164 no 2908 0.131950802741435 4181 2931578 SGTC_1919 st067113 52.3 µM -1.11736714847396 0.13762097254615 no 2909 0.13191868774132 4229 1268243 SGTC_2719 novobiocin 32.65 µM -1.11861432425534 0.137351825592482 no 2910 0.131652354918879 4240 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3284 9108171 64.8615 µM -1.1190922926167 0.137248772897772 no 2911 0.131550383797753 4191 8687505 SGTC_86 0417-1630 471.922 µM -1.11943210858288 0.137175538771681 no 2912 0.131477919664457 4219 3634867 SGTC_2823 7987624 58.44 µM -1.11945752668481 0.137170061960776 no 2913 0.131472500483378 4220 2239440 SGTC_564 3555-0129 330 µM -1.12089270186227 0.136861068621163 no 2914 0.131166768899246 4056 563260 SGTC_182 3448-4371 550.524 µM -1.12102141262463 0.136833380447878 no 2915 0.131139373999933 4070 3491403 SGTC_1504 k297-0033 30 µM -1.1228223148353 0.13644637313169 no 2916 0.130756483053275 4090 4388117 SGTC_1420 4'-methoxyflavone 42 µM -1.12356761492289 0.1362864301168 no 2917 0.130598250635984 4208 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_465 cgp-37157 41 µM -1.12358563272327 0.136282565046557 no 2918 0.130594426970812 4177 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1924 st058459 75.1 µM -1.12554563496261 0.135862564936629 no 2919 0.130178945311743 4171 688683 SGTC_1136 pergolide 1.05886 µM -1.13095141101567 0.134708782267742 no 2920 0.129037771427431 4189 47811 A dopamine receptor agonist. SGTC_2043 5101342 149 µM -1.13129124454457 0.134636475153523 no 2921 0.128966264122174 4233 678451 SGTC_2200 6600604 21.907 µM -1.13369789636503 0.134125168965615 no 2922 0.128460646177854 4239 2904777 SGTC_586 0957-0265 8.15 µM -1.1341653591093 0.134026008898175 no 2923 0.128362595873632 4085 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3340 9146634 11.102 µM -1.13451763496392 0.13395131602503 no 2924 0.128288740357575 4241 4907387 SGTC_1247 0448-0043 5.84 µM -1.13611841662283 0.133612263452086 no 2925 0.127953504172477 4253 3089013 YGL099W LSG1 SGTC_2085 5307070 144.047 µM -1.13673446452546 0.133481939190146 no 2926 0.127824653562834 4170 2840351 SGTC_412 gemfibrozil 100 µM -1.13699882449887 0.133426040943773 no 2927 0.127769388535356 4150 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1494 4358-1428 177 µM -1.13778916314049 0.133259021876976 no 2928 0.127604265570195 4248 1564571 SGTC_2141 5621638 7.665 µM -1.14145821402266 0.13248554062724 no 2929 0.126839645667626 4247 2856238 SGTC_2045 5106652 78.05 µM -1.14239480794121 0.132288591682809 no 2930 0.126644974229792 4211 673349 SGTC_2625 euphol 100 µM -1.14684989461217 0.131354530317779 no 2931 0.125721831966302 4263 6708538 A triterpene alcohol. SGTC_3242 9133940 49.47 µM -1.14708533022349 0.131305295474752 no 2932 0.125673178085321 4251 17248444 SGTC_1892 st058411 7.36 µM -1.14723349124867 0.131274318230312 no 2933 0.12564256664516 4253 3934738 SGTC_2957 9076800 11.52 µM -1.14834079653346 0.131042964611242 no 2934 0.125413951845302 4216 16459615 SGTC_2725 haloperidol 53.21 µM -1.14855981879286 0.130997236824675 no 2935 0.125368766817955 4176 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1270 0831-1170 17.3 µM -1.14905820218278 0.130893224704711 no 2936 0.125265991005399 4258 6764716 SGTC_2273 7815444 169.05 µM -1.15034403426211 0.130625136444181 no 2937 0.125001100519803 4205 2824616 SGTC_369 0957-0393 4.5 µM -1.15075098674513 0.130540368442001 no 2938 0.124917347007199 4265 6997992 SGTC_2926 9010726 65.15 µM -1.15101641117837 0.130485101163561 no 2939 0.124862742031802 4265 2994293 SGTC_1206 3978-0017 132 µM -1.15147022561702 0.130390644381106 no 2940 0.124769418782119 4321 3873677 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.15200830081339 0.130278710890162 no 2941 0.124658831164531 4104 4000243 SGTC_766 1391-0721 126 µM -1.15282328293347 0.130109300261226 no 2942 0.124491462898288 4269 1020919 YIL115C NUP159 SGTC_3214 9129694 49.47 µM -1.15363582581782 0.129940548512305 no 2943 0.124324752032907 4285 17158655 SGTC_2254 7938975 95.19 µM -1.15413427121026 0.129837104643485 no 2944 0.124222562407775 4325 2969277 SGTC_3063 1327-0034 4 µM -1.15819643119247 0.128996198184557 no 2945 0.123391942195793 4141 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2489 cantharidin 73.42 µM -1.15920032327177 0.128788966120785 no 2946 0.123187269863723 4197 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2784 7567673 72.73 µM -1.15931762861726 0.128764766018208 no 2947 0.123163369322452 4201 3471247 SGTC_880 0833-0487 87.2 µM -1.16090326971453 0.128437957640005 no 2948 0.122840619506912 4249 76075 SGTC_1209 2323-2347 50.3 µM -1.1617304741343 0.128267695497914 no 2949 0.122672481538147 4253 5412760 SGTC_1649 st011737 51.3 µM -1.16211945031597 0.128187687362736 no 2950 0.122593473881117 4248 1761035 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.16348011842602 0.127908085556901 no 2951 0.122317380004604 4274 77254 SGTC_2525 harmine 47.85 µM -1.16904673932155 0.126768622786115 no 2952 0.121192400353686 4243 5280953 A monoamine oxidase inhibitor SGTC_1007 4101-0031 70 µM -1.17012091233712 0.12654956035681 no 2953 0.120976156942178 4228 1146276 SGTC_2740 felodipine 17.08 µM -1.17450322652575 0.125658582117306 no 2954 0.120096760167007 4298 3333 L-type calcium channel blocker SGTC_1753 st043925 64 µM -1.17748915458743 0.125054018911753 no 2955 0.119500161895462 4300 670181 SGTC_2111 5486399 200 µM -1.17774505719712 0.125002300786286 no 2956 0.119449129155591 4213 689674 SGTC_892 0929-0076 29 µM -1.18179469005155 0.124185855226461 no 2957 0.118643587625077 4241 5751038 SGTC_206 4546-0025 72.014 µM -1.18295058667397 0.12395350105812 no 2958 0.118414365713794 4322 6620745 YIL048W NEO1 SGTC_2529 gangaleoidin 93.61 µM -1.18983860980645 0.122575204092373 no 2959 0.117054915550157 4290 4565183 SGTC_3301 9125354 19.7965 µM -1.19258937113871 0.122027791052481 no 2960 0.116515115273131 4277 41905162 SGTC_585 0kpi-0023 191 µM -1.19318595676115 0.121909294920131 no 2961 0.116398276642631 4212 64601 SGTC_3095 9117207 49.47 µM -1.19492926380311 0.121563495826042 no 2962 0.116057334115972 4251 17015229 SGTC_85 0868-0259 160.055 µM -1.20125588619502 0.120314352078015 no 2963 0.114825978375733 4185 83173 SGTC_1745 st081495 74 µM -1.20163260623908 0.120240257842144 no 2964 0.114752951345197 4152 13842402 YBL026W LSM2 SGTC_140 0062-0056 502.533 µM -1.2026380727615 0.120042657610415 no 2965 0.114558203871524 4207 3758964 SGTC_908 3448-7491 47.7 µM -1.20296136501647 0.119979170955744 no 2966 0.114495635830865 4288 1203031 SGTC_1900 st060200 72.8 µM -1.20319800901236 0.119932714894657 no 2967 0.114449852595414 4281 688945 SGTC_2617 dihydrotanshinone i 20.83 µM -1.20557359775706 0.11946706075779 no 2968 0.113990972213936 4250 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2245 6637752 200 µM -1.2076740801759 0.119056395733441 no 2969 0.113586325924206 4339 681890 SGTC_110 0850-0284 111.64 µM -1.20877662525205 0.118841236631344 no 2970 0.113374337063278 4109 3906265 SGTC_1406 3909-7906 11.9 µM -1.20882831426191 0.118831156385497 no 2971 0.113364405628617 4310 X1406 SGTC_331 k048-0133 24.5 µM -1.20972150415173 0.118657064373837 no 2972 0.113192887703634 4250 6813582 SGTC_144 4161-2749 112.381 µM -1.21121012256112 0.118367317732795 no 2973 0.112907442096262 4253 797501 YMR168C CEP3 SGTC_1723 st034307 2.5525 µM -1.21150797342345 0.11830940375028 no 2974 0.112850390332254 4317 867466 SGTC_25 0118-0223 35.662 µM -1.2124199155155 0.118132210730896 no 2975 0.11267584060444 4305 5333628 SGTC_1133 3473-0247 50 µM -1.21359969579821 0.117903254541656 no 2976 0.112450311639381 4272 711311 SGTC_1388 3346-4487 254 µM -1.21561760832963 0.117512372781241 no 2977 0.112065311647044 4363 3345614 SGTC_3343 9148379 18.9835 µM -1.21745464067465 0.117157327192567 no 2978 0.111715642240369 4327 1955036 SGTC_1929 genistein trimethyl ether 50.5 µM -1.21789959164399 0.117071445397185 no 2979 0.111631065711972 4275 136420 SGTC_1263 0774-1208 64.8 µM -1.21898054992582 0.11686299108998 no 2980 0.111425787413496 4338 906585 SGTC_1220 1838-0075 193 µM -1.21905602342718 0.116848446450684 no 2981 0.11141146479079 4219 5529645 SGTC_1491 4138-0063 26.5 µM -1.2196157508951 0.116740620369632 no 2982 0.111305286308731 4292 23883227 SGTC_818 4072-2707 53.5 µM -1.21996091976176 0.11667416210178 no 2983 0.111239845016195 4207 882871 SGTC_2382 9035899 200 µM -1.22061719579109 0.116547877753176 no 2984 0.111115496248507 4288 6462679 SGTC_2035 5154463 94.595 µM -1.22096956847043 0.116480112219956 no 2985 0.111048771055222 4320 2769623 SGTC_207 4185-0010 4.486 µM -1.22266423442228 0.116154597851545 no 2986 0.110728270445976 4374 3761753 SGTC_824 1304-0008 100 µM -1.22625126578599 0.115467725444721 no 2987 0.110052067285061 4340 768245 SGTC_1561 5-methoxyflavone 52.9 µM -1.22665445161795 0.115390701132871 no 2988 0.109976247009837 4264 94525 SGTC_622 1348-1566 26.3 µM -1.22757368557452 0.115215227930613 no 2989 0.109803522536846 4299 7340407 SGTC_2551 apiole 73.87 µM -1.22884480844903 0.114972895058498 no 2990 0.109564998887097 4204 10659 A possible DNA adduct former. SGTC_1138 3761-0006 1.03 µM -1.2288768377157 0.114966793533483 no 2991 0.109558993469025 4339 12061087 SGTC_2054 5233173 129 µM -1.23048660952606 0.114660431130089 no 2992 0.109257469151931 4338 6889 SGTC_2588 indole-3-carbinol 100 µM -1.23319307943588 0.114146661810219 no 2993 0.108751868378822 4332 3712 Induces cell cycle arrest. SGTC_1832 st054113 55 µM -1.23346858322383 0.114094455009146 no 2994 0.108700495500375 4326 1251267 SGTC_1413 3910-0535 34.4 µM -1.23370993380094 0.114048734075339 no 2995 0.10865550547567 4335 2876951 SGTC_2261 9010538 184.68 µM -1.23484120432526 0.113834602591232 no 2996 0.108444804480827 4324 6457250 SGTC_2413 inermin 26.06 µM -1.23621972605194 0.113574057882517 no 2997 0.108188450113485 4373 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1309 pyrazolanthrone 13.4 µM -1.23742709096287 0.113346211827715 no 2998 0.107964283198326 4285 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2356 9061756 188.97 µM -1.23914837449654 0.113021946411162 no 2999 0.10764527754963 4351 20104043 SGTC_3302 9125395 16.351 µM -1.23924639086585 0.113003501460679 no 3000 0.107627132624964 4259 17599668 SGTC_2285 7945142 200 µM -1.24008563996133 0.112845657541969 no 3001 0.107471859893934 4354 2970608 SGTC_1391 3442-0225 151 µM -1.24047776062707 0.112771962421377 no 3002 0.107399367493456 4282 5227075 SGTC_1689 st020265 53.493 µM -1.24226408521082 0.112436675592138 no 3003 0.107069570881403 4333 5758320 YPR016C TIF6 SGTC_2858 9025781 8.96 µM -1.24410443047678 0.112091994707837 no 3004 0.106730565333804 4184 4894980 YPL153C RAD53 SGTC_1261 0712-0010 12.7 µM -1.24452564208303 0.112013211724088 no 3005 0.106653084015655 4322 2840123 SGTC_2373 9071805 200 µM -1.24734848100414 0.111486252417927 no 3006 0.106134874082416 4334 10149009 SGTC_2277 7947813 106.88 µM -1.24820007315317 0.111327628576221 no 3007 0.105978898593239 4358 1246798 SGTC_1462 k081-0014 26.5 µM -1.24878096756131 0.11121951962256 no 3008 0.105872598497745 3799 3270634 SGTC_3176 9106582 49.47 µM -1.25313955367514 0.110410750236344 no 3009 0.105077461737716 4307 17018027 SGTC_55 0767-0285 6.563 µM -1.25675440301412 0.109743192762547 no 3010 0.104421290834854 4245 3116166 SGTC_3179 9107801 49.47 µM -1.25740779402687 0.109622840285661 no 3011 0.104303004201232 4327 4818259 SGTC_2659 sanguinarine 24.21 µM -1.25767825107572 0.109573050727848 no 3012 0.10425407044141 4275 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_687 k029-0044 34.9 µM -1.26140740025544 0.108888191166078 no 3013 0.103581051733914 4413 5829338 SGTC_588 3970-1144 52.9 µM -1.26336636746447 0.108529661522454 no 3014 0.103228772577736 4219 1888707 SGTC_2262 9014885 67.46 µM -1.26348594938307 0.10850780320713 no 3015 0.103207296486386 4342 6457424 SGTC_2654 protoveratrine a 100 µM -1.26459886495983 0.108304525844368 no 3016 0.10300758008034 4344 5702278 A heart drug and vasodilator. SGTC_2742 clothiapine 36.27 µM -1.27016196470432 0.107292517529248 no 3017 0.102013471505904 4380 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_299 1273-0059 1.44 µM -1.27237216778271 0.106892347825523 no 3018 0.101620459053724 4148 2848077 SGTC_3075 9116269 49.47 µM -1.27405440408125 0.106588491964143 no 3019 0.101322068019531 4354 17015205 YNL244C SUI1 SGTC_229 benomyl 22.8748 µM -1.27419923528473 0.106562360841854 no 3020 0.101296408084137 4369 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2263 7948595 193.29 µM -1.27428820570588 0.106546310676058 no 3021 0.101280647425028 4355 2971371 SGTC_2921 7974240 10.71 µM -1.27487301683196 0.106440854828438 no 3022 0.101177095565849 4434 2979074 YDR527W RBA50 SGTC_2134 5324836 1.464 µM -1.27607638959581 0.106224094217385 no 3023 0.100964258446516 4313 699272 SGTC_1778 st046819 58.9 µM -1.27693433364888 0.106069749652382 no 3024 0.10081271575035 4386 671715 SGTC_3226 9131256 49.47 µM -1.28345955792028 0.104901158879858 no 3025 0.0996655597754537 4317 17178073 SGTC_1298 1079-1278 263 µM -1.28587306657948 0.104471297990614 no 3026 0.0992436823964858 4330 2840950 SGTC_1018 4259-0013 28.1 µM -1.28662063516037 0.104338410616515 no 3027 0.0991132738680579 4403 6801262 SGTC_692 k241-0027 77.8 µM -1.28709586293293 0.104253998105369 no 3028 0.0990304386254095 4392 3600480 SGTC_985 1493-0307 8.71 µM -1.28750219432781 0.10418186260317 no 3029 0.0989596526320684 4381 3278274 SGTC_1276 0871-0068 94.2 µM -1.29244824583882 0.10330669553138 no 3030 0.0981009789469845 4384 3414906 SGTC_3108 9121785 49.47 µM -1.29390522234936 0.103049914981239 no 3031 0.0978490802079002 4195 17140271 SGTC_1380 2291-0730 164 µM -1.29657084668845 0.102581320414472 no 3032 0.0973894443939416 4371 2999191 SGTC_2367 9070478 135.38 µM -1.30050676237103 0.101892254275901 no 3033 0.0967136700347663 4306 572802 SGTC_1810 st050138 53 µM -1.30377485406604 0.101322669872808 no 3034 0.09615517934508 4377 3444541 SGTC_3151 9099821 49.47 µM -1.31005877830856 0.100233991582196 no 3035 0.095087976017502 4318 17174189 SGTC_2930 9013230 14.89 µM -1.31218311972424 0.0998678914450361 no 3036 0.0947291779867231 4356 2995857 SGTC_2886 9058944 51.95 µM -1.31267187754478 0.0997837993382877 no 3037 0.0946467689074117 4295 4949929 SGTC_1045 1348-1485 165 µM -1.31401630196563 0.0995527543295413 no 3038 0.0944203591524021 4356 6810614 SGTC_2520 obtusaquinone 4.71 µM -1.31552126009031 0.099294584979436 no 3039 0.0941673885174951 4427 5967872 SGTC_1426 4048-4480 71.7 µM -1.31883375614163 0.0987280650911747 no 3040 0.0936123481823131 4402 14224343 SGTC_1635 st007035 42.4 µM -1.3191922453266 0.0986668965962145 no 3041 0.0935524250678522 4345 3716403 SGTC_1730 st033808 45.1 µM -1.32128567055485 0.0983102523351874 no 3042 0.0932030650297934 4304 1045166 SGTC_2251 lansoprazole 556 µM -1.33006329979983 0.0968251376552084 no 3043 0.0917487080982273 4340 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_685 1278-0033 54.9 µM -1.33355861460391 0.09623836319093 no 3044 0.0911742768768028 4464 3590572 SGTC_223 busulfan 5 mM -1.33365939854097 0.0962214829859807 no 3045 0.0911577533709489 4378 2478 A DNA alkylator. SGTC_2862 9027634 71.43 µM -1.33535983863812 0.0959370059626252 no 3046 0.090879301291753 4343 5012562 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.34974009885616 0.0935559413140742 no 3047 0.088549682560745 4432 165521 SGTC_1293 1000-1278 195 µM -1.35108019547778 0.0933362927734026 no 3048 0.0883348723834871 4418 678847 SGTC_930 2810-3379 265 µM -1.3538219679131 0.0928880900679085 no 3049 0.0878965916597879 4407 1015764 SGTC_2841 9004761 38.96 µM -1.35885766346806 0.0920690441244859 no 3050 0.087095848340208 4355 2991039 SGTC_3003 9075612 71.4286 µM -1.3593043486192 0.0919966506770785 no 3051 0.0870250833160245 4423 6501993 SGTC_2079 5212404 121 µM -1.36070331821882 0.0917701949639356 no 3052 0.0868037327830595 4364 758462 SGTC_512 prima-1 270 µM -1.36454789422197 0.091149988187201 no 3053 0.0861975956051326 4415 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1296 1068-0102 11.9 µM -1.36564182152388 0.0909740852481006 no 3054 0.0860257065821262 4407 767053 SGTC_2853 9015042 58.44 µM -1.36657201389673 0.0908247090063425 no 3055 0.0858797471297044 4335 6457456 SGTC_2605 digitonin 300 nM -1.36756131467289 0.0906660405483395 no 3056 0.085724716256846 4420 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2493 resveratrol 26.09 µM -1.36771921728345 0.0906407344762647 no 3057 0.0856999911308538 4340 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.36785993504776 0.0906181869311076 no 3058 0.0856779613873437 4405 803109 SGTC_2702 st077768 96.8 µM -1.37147586033792 0.0900402256844328 no 3059 0.0851133317938433 4391 6484119 SGTC_304 1310-0298 97 µM -1.37255085086613 0.0898689309537243 no 3060 0.084946010092477 4170 1550234 SGTC_1376 2910-0861 41.3 µM -1.37318361204852 0.0897682167151715 no 3061 0.0848476365061971 4362 1112859 SGTC_1211 1056-0033 32.3 µM -1.37358794878471 0.0897039038958934 no 3062 0.0847848201644766 4459 6741922 SGTC_2938 9059746 27.26 µM -1.37500247758176 0.0894791819168826 no 3063 0.0845653382964287 4413 6471769 SGTC_875 0709-0210 25.7 µM -1.37737127155136 0.0891037967692738 no 3064 0.0841987451097946 4394 6251364 SGTC_924 2046-0044 21.3 µM -1.37934255277183 0.0887923004076874 no 3065 0.0838945812100859 4405 3623589 SGTC_2873 9040596 71.43 µM -1.38043879549754 0.0886194264122442 no 3066 0.0837257910505555 4391 6463863 SGTC_919 tnp00227 403.569 nM -1.38324750702961 0.0881776457320134 no 3067 0.0832944937494483 4372 1269246 A methoxyflavone. YNL221C POP1 SGTC_2566 crystal violet carbinol 226 nM -1.38587029058333 0.0877665937738614 no 3068 0.0828932570543085 4401 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2180 6301957 200 µM -1.39198895734042 0.0868132141892516 no 3069 0.0819628709484147 4448 845462 SGTC_2614 arthonioic acid 13.39 µM -1.39717334382601 0.0860114832963422 no 3070 0.0811807252635548 4284 6710684 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.40216380084665 0.0852449877770796 no 3071 0.0804331692943319 4430 6708760 SGTC_1092 toremifene 6.32 µM -1.40287833058153 0.0851356617010328 no 3072 0.0803265618407477 4430 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2276 7947513 42.08 µM -1.40525856221435 0.084772234133277 no 3073 0.0799722027847171 4377 2105100 SGTC_683 panaxydol 45 µM -1.40747222655635 0.0844352842350342 no 3074 0.0796437036020257 4454 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_64 000l-0018 272.079 µM -1.41017566543693 0.0840251481324405 no 3075 0.0792439096828326 4360 6811119 SGTC_1091 telmisartan 47.6 µM -1.41140866666082 0.0838385881435466 no 3076 0.0790620744873699 4465 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_425 3825-7017 13.1 µM -1.41170963831267 0.08379309672123 no 3077 0.0790177371154878 4465 3397440 SGTC_1079 idarubicin 2.36 µM -1.41171606168676 0.0837921260398017 no 3078 0.0790167910671185 4454 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2033 5192550 145 µM -1.41248265557127 0.0836763412672522 no 3079 0.0789039470633508 4460 182073 SGTC_648 0375-0473 33.3 µM -1.41723702965996 0.0829609333600093 no 3080 0.0782068193985216 4419 1713139 SGTC_1076 itraconazole 331 nM -1.41761026674363 0.0829049663956905 no 3081 0.0781522905220859 4445 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2103 5378138 10 µM -1.41793304231858 0.0828565890502612 no 3082 0.0781051571867954 4527 244142 SGTC_1648 st011736 69.8 µM -1.41932057685435 0.0826488683471688 no 3083 0.0779027878816421 4434 2855514 SGTC_1603 st002045 67.8 µM -1.42109792952487 0.0823833628339382 no 3084 0.0776441459215899 4437 5887985 SGTC_2430 5571206 200 µM -1.42174367601995 0.0822870587810932 no 3085 0.0775503379404155 4425 1731771 SGTC_1451 4152-0210 104 µM -1.42348385796574 0.0820279571000104 no 3086 0.0772979691216047 4481 659563 SGTC_2395 5646831 180.19 µM -1.42392689444978 0.0819620901453764 no 3087 0.0772338177739014 4435 6808628 SGTC_3326 9140064 16.379 µM -1.42574735242865 0.0816918579831246 no 3088 0.076970641360674 4403 1868434 SGTC_1811 st050069 61.5 µM -1.42653310885721 0.0815754265795231 no 3089 0.0768572584849985 4434 3877702 SGTC_2596 sinensetin 100 µM -1.43872205670147 0.0797852892785195 no 3090 0.0751146437388362 4462 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1623 st003709 20.3 µM -1.43894644956168 0.0797526144860015 no 3091 0.0750828478238829 4431 16192618 SGTC_1875 nocodazole 6 µM -1.43948917552167 0.0796736277135619 no 3092 0.075005987327854 4491 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2647 atorvastatin 60.16 µM -1.44292716293146 0.0791746472207914 no 3093 0.0745204952220912 4437 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3294 9122953 26.2835 µM -1.44469293276391 0.0789192895039962 no 3094 0.0742720779401833 4444 16459826 SGTC_1855 st056195 39.6 µM -1.44627407528119 0.0786911616443486 no 3095 0.074050172071507 4381 4028379 SGTC_251 melphalan 456.522 µM -1.44728423871784 0.078545676710526 no 3096 0.0739086658104409 4502 460612 A DNA alkylator. SGTC_1186 1319-0216 26 µM -1.44916905842203 0.0782747679929266 no 3097 0.0736451880762788 4507 4565136 SGTC_2757 clomiphene 4.22 µM -1.45117877639772 0.077986688630266 no 3098 0.0733650425688275 4470 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2789 5281112 71.43 µM -1.45541960127776 0.077381436056669 no 3099 0.0727765665886803 4466 765948 SGTC_2765 myclobutanil 7.74 µM -1.45648466938757 0.0772299910385611 no 3100 0.0726293422939338 4478 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1333 1482-0047 286 µM -1.45693395932338 0.0771661728180401 no 3101 0.0725673054243457 4500 3811116 SGTC_549 1661-1316 519 µM -1.4581945409458 0.0769873307110468 no 3102 0.0723934640454069 4481 2857282 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.46096254254929 0.0765957324745554 no 3103 0.072012860616541 4434 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_417 st075190 100 µM -1.46239853984434 0.0763931750087611 no 3104 0.0718160146694963 4464 222757 SGTC_617 3770-0098 35 µM -1.46377089435866 0.0761999759170356 no 3105 0.0716282787524301 4392 5962639 SGTC_3305 9127027 53.8275 µM -1.46848616950648 0.0755389962513101 no 3106 0.0709861051699303 4418 41905295 SGTC_2 0422-0095 29 µM -1.47084501388723 0.0752099810269853 no 3107 0.0706665179041293 4388 6790840 SGTC_1703 st026983 48.3 µM -1.47198433788861 0.0750514581997566 no 3108 0.0705125535144455 4503 1104023 SGTC_456 gingerol 170 µM -1.47359065821167 0.0748283916738304 no 3109 0.0702959190551301 4508 442793 A herb. SGTC_1736 st036774 51 µM -1.47456466723821 0.0746933795212744 no 3110 0.0701648099806492 4517 1272247 SGTC_716 1683-5115 658 µM -1.47693421663004 0.0743657009855355 no 3111 0.0698466359113703 4476 723597 SGTC_1760 st045453 10.4495 µM -1.48440488787679 0.0733397860511627 no 3112 0.0688507694125995 4502 3323419 YIL048W NEO1 SGTC_143 4032-1194 15.74 µM -1.48534676752418 0.0732112140464722 no 3113 0.0687259945638662 4518 1806963 SGTC_3031 9088762 49.47 µM -1.48585652969751 0.0731417005303779 no 3114 0.0686585369376605 4458 205253 SGTC_1841 st054148 70 µM -1.48793330992166 0.0728590231317398 no 3115 0.0683842410413301 4502 675442 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.49120595923598 0.072415270508945 no 3116 0.0679537147962008 4513 688788 SGTC_628 1636-0253 16 µM -1.49186065833348 0.0723267461135068 no 3117 0.067867839051707 4484 4456143 SGTC_854 0422-0053 192 µM -1.4932635635585 0.0721373331279853 no 3118 0.0676841046462689 4517 3596728 SGTC_2771 fluoxetine 41.05 µM -1.49469023349463 0.0719451017370472 no 3119 0.0674976521721419 4478 3386 A selective serotonin reuptake inhibitor. SGTC_1487 3970-0795 2.82 µM -1.49572519938605 0.0718058950729118 no 3120 0.0673626403677843 4545 3765103 SGTC_1235 benzylparaben 21.5 µM -1.49787502555322 0.0715173960061615 no 3121 0.0670828617379621 4527 7180 SGTC_948 3448-0295 75.3 µM -1.49846520007996 0.0714383524839393 no 3122 0.0670062137816349 4470 678569 SGTC_1874 staurosporine 7.6 µM -1.49847813918527 0.0714366202692123 no 3123 0.0670045340955188 4486 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2366 9070441 60.58 µM -1.50395171225059 0.070706736098978 no 3124 0.0662969002457773 4474 6837235 SGTC_955 1216-0110 33 µM -1.51402586123987 0.0693783766010014 no 3125 0.0650096402509142 4470 3619719 SGTC_277 nystatin 15.5 µM -1.51471297593689 0.0692884798797567 no 3126 0.0649225534479919 4528 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2473 5854593 8.94 µM -1.51495354574725 0.0692570268216517 no 3127 0.0648920843836488 4443 2872951 SGTC_796 1234-0020 70.7 µM -1.51668469191582 0.0690310141363352 no 3128 0.0646731555269827 4443 46495034 SGTC_2974 9094440 9.66 µM -1.51727990377352 0.0689534367170355 no 3129 0.0645980149104266 4477 25236134 SGTC_2031 5180455 200 µM -1.51736794541723 0.0689419674455699 no 3130 0.0645869061341923 4492 29949 SGTC_3133 9127736 49.47 µM -1.51827802885633 0.0688234961311441 no 3131 0.0644721620276764 4506 27243420 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.52024770109789 0.0685676289649991 no 3132 0.064224366409817 4506 5377381 SGTC_3030 9087619 49.47 µM -1.52037130050417 0.0685515974776489 no 3133 0.0642088416412596 4517 25236973 SGTC_801 0866-0028 10.1 µM -1.52257171647899 0.0682666757211912 no 3134 0.0639329451793236 4540 6849771 SGTC_3260 9137109 49.47 µM -1.524247222934 0.068050335651175 no 3135 0.0637234827947115 4481 17478346 SGTC_1799 st045822 46.1415 µM -1.52567716168048 0.0678661220406442 no 3136 0.0635451424767761 4495 3674992 SGTC_3232 9132874 49.47 µM -1.52931077865947 0.0673997496099037 no 3137 0.0630937094035049 4480 3784940 SGTC_619 1652-1634 108 µM -1.53088549810568 0.067198406379813 no 3138 0.0628988469671878 4509 5400454 SGTC_2986 9022445 71.43 µM -1.53127679223227 0.0671484478205148 no 3139 0.0628504993828843 4482 6459286 SGTC_2888 9058547 12.99 µM -1.5316006178813 0.0671071250362016 no 3140 0.0628105099808576 4444 16476514 SGTC_3289 9119912 71.43 µM -1.53178807056189 0.0670832135390702 no 3141 0.0627873704110651 4507 17014829 SGTC_2008 4012253 172 µM -1.53282851870302 0.0669506135534531 no 3142 0.0626590559501566 4496 603940 SGTC_1979 st071809 45.3 µM -1.53360821991164 0.0668513774442431 no 3143 0.062563032445906 4556 4976333 SGTC_1748 st037455 53.6035 µM -1.53503803371783 0.066669694286321 no 3144 0.0623872429272345 4518 580690 SGTC_2442 5158906 48.48 µM -1.53741060034157 0.0663690611239674 no 3145 0.0620963960826348 4519 1893835 SGTC_776 4476-4378 112 µM -1.53907163254108 0.0661592135182888 no 3146 0.0618934047558885 4561 2892008 SGTC_651 3253-0966 34.4 µM -1.53999805951327 0.0660423962220143 no 3147 0.0617804132139084 4538 781462 SGTC_2456 5770359 74.46 µM -1.54264786720745 0.0657091523512445 no 3148 0.0614581186317688 4503 3118787 SGTC_615 k087-0205 167 µM -1.54425371124521 0.0655078342152723 no 3149 0.0612634407657367 4528 9642773 SGTC_3136 9095672 49.47 µM -1.54880652973845 0.0649396659978384 no 3150 0.0607141176996508 4376 17217380 SGTC_183 3914-0051 30.55 µM -1.55143495088298 0.0646133986787795 no 3151 0.0603987424068171 4509 1596232 SGTC_2544 sphondin 68.51 µM -1.55160606938133 0.0645922018718689 no 3152 0.0603782550119778 4487 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2177 5811945 192 µM -1.55614827337313 0.0640315218256275 no 3153 0.0598364191136829 4532 5343475 SGTC_3299 9121982 43.1275 µM -1.55622946751709 0.0640215339284865 no 3154 0.0598267682955458 4528 17594604 YPL160W CDC60 SGTC_1468 k284-1086 134 µM -1.5616179826049 0.0633613829481733 no 3155 0.059189005296865 4534 15996457 SGTC_433 pimozide 108 µM -1.56356979862391 0.0631235761004785 no 3156 0.0589593160322349 4446 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1306 1185-0270 9.02 µM -1.56633112304266 0.0627883277478823 no 3157 0.0586355592181301 4539 1548076 SGTC_715 0868-0130 184 µM -1.56672050456826 0.0627411653312535 no 3158 0.0585900179201651 4575 2876258 SGTC_2603 homopterocarpin 100 µM -1.56799108944086 0.0625874623748986 no 3159 0.0584416059378819 4520 101795 A weak amylase inhibitor. SGTC_264 promethazine 12.5 mM -1.56819745874964 0.0625625255620017 no 3160 0.0584175286504005 4389 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3137 9097352 49.47 µM -1.56980766119388 0.0623682212613538 no 3161 0.0582299323529544 4518 44120435 SGTC_2002 4023503 131 µM -1.59700908097917 0.0591564488655678 no 3162 0.0551318415075919 4527 4736863 YCR052W RSC6 SGTC_495 decylubiquinone 155 µM -1.5981555620857 0.0590239833059494 no 3163 0.0550041803512617 4536 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3097 9117246 49.47 µM -1.59908362066115 0.0589169250136693 no 3164 0.0549010117996103 4567 16423892 SGTC_1104 tacrolimus 29.8 µM -1.601198517365 0.0586735255666245 no 3165 0.0546664785686408 4599 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1224 0823-0416 294 µM -1.60165705429935 0.0586208576854363 no 3166 0.0546157333780327 4570 3598164 SGTC_704 1310-0270 142 µM -1.61322466248072 0.0573044329784688 no 3167 0.0533478536057435 4527 5718033 SGTC_1143 3454-2408 5.08 µM -1.61654872913875 0.0569304799045386 no 3168 0.0529878633742925 4553 X1143 SGTC_2828 7998861 71.43 µM -1.62231596416079 0.0562862356395944 no 3169 0.052367856107586 4567 2988188 SGTC_1560 lithocholic acid 53.1 µM -1.62283379766715 0.0562286720091965 no 3170 0.0523124693441948 4502 9903 A bile acid which acts as a detergent. SGTC_2913 7966556 36.57 µM -1.62824656143171 0.0556297505669267 no 3171 0.0517363077668005 4464 2976516 SGTC_2022 5136654 200 µM -1.6303058731178 0.0554032146685551 no 3172 0.0515184334569821 4544 1713771 SGTC_1031 k035-0009 16 µM -1.63081049066373 0.0553478151568283 no 3173 0.0514651565858409 4592 5180959 SGTC_2092 5303694 80.6725 µM -1.63757670074671 0.0546092040189798 no 3174 0.0507550133444779 4578 1963699 SGTC_2233 sulbentine 40.3845 µM -1.64784859721554 0.0535028286345047 no 3175 0.0496918718721701 4586 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.64831529552018 0.053452985962935 no 3176 0.0496439938078708 4589 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1027 k015-0025 8.67 µM -1.6505965721545 0.053209878355799 no 3177 0.0494104896476691 4547 3598955 SGTC_3348 9149464 3.537 µM -1.65169287936009 0.0530933610035891 no 3178 0.0492985874979896 4518 1951442 SGTC_82 0054-0107 293.755 µM -1.6520562096826 0.0530547903181386 no 3179 0.049261546360438 4548 3104697 SGTC_895 0964-0006 13.7 µM -1.65477845527086 0.052766506654482 no 3180 0.0489847229024883 4577 6738897 SGTC_1751 st044839 27.194 µM -1.6563483919945 0.0526008174782574 no 3181 0.0488256429192676 4610 5291326 SGTC_2288 7946289 167.31 µM -1.65730702814192 0.0524998474200124 no 3182 0.048728708554484 4577 1246052 SGTC_611 3453-1652 23.7 µM -1.65868932393072 0.052354525583973 no 3183 0.0485892058983985 4571 1560575 SGTC_3251 9135047 49.47 µM -1.65980402657532 0.0522375688052728 no 3184 0.0484769417283965 4607 17682963 SGTC_2840 9008771 71.43 µM -1.66023498497854 0.0521924074624712 no 3185 0.0484335945906775 4518 2992978 SGTC_1884 5633444 25 µM -1.66367475544083 0.0518330548482411 no 3186 0.0480887218910805 4516 5724239 SGTC_788 1182-0090 188 µM -1.66744138348759 0.0514418138916593 no 3187 0.04771333540039 4571 5715185 SGTC_1631 benzylvanillin 81.9 µM -1.66770222073525 0.0514148078261467 no 3188 0.0476874271813741 4582 75506 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.6682528117542 0.0513578388154316 no 3189 0.0476327755386514 4564 1377 SGTC_1813 st051246 8.6015 µM -1.66833020477561 0.0513498350762053 no 3190 0.047625097533229 4539 5291959 SGTC_399 oxolinic acid 75 µM -1.67380757638724 0.0507858982929044 no 3191 0.0470842114330693 4568 4628 A DNA gyrase inhibitor. SGTC_927 2425-1185 123 µM -1.68379593585657 0.0497702266008598 no 3192 0.0461105564652824 4542 730375 SGTC_1056 3448-1962 115 µM -1.69437486415601 0.0487122409265482 no 3193 0.0450970363951296 4548 715507 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.70053231754647 0.048104766541781 no 3194 0.0445154214323993 4613 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3026 9090633 49.47 µM -1.70972725444322 0.0472089256857375 no 3195 0.0436581602231817 4605 25236842 SGTC_992 3909-8734 162 µM -1.71229516266468 0.0469611437224838 no 3196 0.0434211438453861 4606 4288319 SGTC_2741 miltefosine 3.04 µM -1.71256234501848 0.0469354228416674 no 3197 0.0433965428537549 4635 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1311 1190-0148 100 µM -1.72143577436293 0.0460876025665496 no 3198 0.0425858886376826 4618 1961333 SGTC_1183 1254-0324 198 µM -1.72508336474137 0.0457426771761397 no 3199 0.0422562250032777 4631 5799357 SGTC_532 1548-0774 215 µM -1.73112473175261 0.0451759572030999 no 3200 0.0417147600848497 4645 5932993 SGTC_659 k018-0002 107 µM -1.73751721176187 0.0445824661985277 no 3201 0.0411479593247207 4585 6797879 YHR007C ERG11 SGTC_3111 9122088 49.47 µM -1.73828725427904 0.0445113996714262 no 3202 0.0410801055402752 4560 16876704 SGTC_2364 9055074 200 µM -1.74246845675636 0.0441271119535294 no 3203 0.0407132531492396 4607 6470630 SGTC_446 go6976 132 µM -1.7426063406973 0.0441144849605146 no 3204 0.0407012008494088 4615 3501 A protein kinase C inhibitor. SGTC_3332 9141069 11.198 µM -1.74309792745025 0.0440694906422317 no 3205 0.0406582552949848 4553 17332883 SGTC_2088 5278280 127.392 µM -1.74485131052504 0.043909306975515 no 3206 0.0405053772703589 4629 791502 SGTC_1077 5-fluorocytosine 377 nM -1.75037537693693 0.0434077135601426 no 3207 0.040026780984088 4636 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2813 7971799 71.43 µM -1.75293342898493 0.0431770108666043 no 3208 0.0398067173421421 4589 2234054 SGTC_2331 7980721 200 µM -1.76505492189271 0.0420972421475222 no 3209 0.0387772678534486 4572 2981221 SGTC_329 k048-0121 21.3 µM -1.77071512454376 0.0416005772161542 no 3210 0.0383040430481756 4624 6832902 SGTC_804 1595-0054 20.9 µM -1.77734417146682 0.0410249459861162 no 3211 0.0377558151226537 4614 761523 Stimulates phospholipase C. SGTC_1039 k821-0043 94 µM -1.77892936898202 0.0408882572672384 no 3212 0.0376256712176043 4596 15992768 SGTC_2283 7944793 200 µM -1.7821749370963 0.0406095503693198 no 3213 0.0373603542747555 4593 2970533 SGTC_3071 9117417 49.47 µM -1.7850843917541 0.040361019129092 no 3214 0.0371238146392126 4580 45595590 YGL055W OLE1 SGTC_1779 st039427 55 µM -1.78967037899377 0.039971784345457 no 3215 0.0367534584885145 4610 1124498 SGTC_3032 9089427 49.47 µM -1.79411222592659 0.0395976971088012 no 3216 0.0363976290149709 4595 17173707 SGTC_2490 carminic acid 95.39 µM -1.82474525406592 0.0370946931977955 no 3217 0.0340197403737936 4630 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2225 6654152 15.4 µM -1.82756136342003 0.0368712304085533 no 3218 0.0338077044240722 4596 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3339 9145883 14.936 µM -1.83012494575543 0.0366687642527589 no 3219 0.0336156287604319 4574 2030670 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.83570945304518 0.0362308596079361 no 3220 0.0332003195657075 4636 6710655 SGTC_916 4466-0038 42 nM -1.8359659691169 0.0362108483983956 no 3221 0.0331813449372398 4669 5722064 YGL116W CDC20 SGTC_807 1315-0151 48 µM -1.84610623822366 0.0354270114947055 no 3222 0.0324383906247206 4636 4011080 SGTC_108 0509-0257 621.132 µM -1.85173238014876 0.0349981499855985 no 3223 0.0320321309427214 4621 536624 SGTC_889 0919-1524 82.7 µM -1.86937261957185 0.033681041556621 no 3224 0.030785495590298 4668 3905452 SGTC_1241 0364-0022 50.8 µM -1.87093063043543 0.0335666996159618 no 3225 0.03067734837881 4653 4563895 SGTC_690 glyoxal 20.3 µM -1.87904173871947 0.0329765783035909 no 3226 0.0301193971468421 4468 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2290 7904846 200 µM -1.88617777328836 0.032464493000799 no 3227 0.0296355013262112 4675 2962154 SGTC_907 3448-6986 75.5 µM -1.88780828276188 0.0323484122578056 no 3228 0.029525846420679 4656 590582 SGTC_397 arbidol 50 µM -1.89056620549895 0.0321528473810374 no 3229 0.0293411375149828 4672 131410 A RNA synthesis inhibitor. SGTC_2511 berberine 10.47 µM -1.89297473215109 0.0319828575832535 no 3230 0.0291806149011777 4636 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_990 3985-0011 41.3 µM -1.89389478111918 0.0319181182687505 no 3231 0.0291194886837893 4630 5399565 YGL099W LSG1 SGTC_869 0564-0080 44.1 µM -1.89853841115471 0.0315930184997123 no 3232 0.0288125964107787 4649 6843321 SGTC_666 0272-0154 136 µM -1.90003717522699 0.0314886762921215 no 3233 0.028714120619339 4653 6870312 SGTC_1354 1498-1681 81 µM -1.90754364515332 0.0309703622782124 no 3234 0.0282251124234263 4686 5754243 SGTC_2612 dictamnine 15.46 µM -1.91638807119611 0.030368744501248 no 3235 0.0276578590249718 4577 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.91792394207784 0.0302652644023296 no 3236 0.0275603279542146 4679 1273210 SGTC_1859 st055998 20 µM -1.92405727419347 0.0298549374115597 no 3237 0.027173702393399 4608 676301 SGTC_3250 9135583 49.47 µM -1.92578802783354 0.0297399863887033 no 3238 0.0270654234809309 4669 7699353 SGTC_1179 1021-1431 9.29 µM -1.92741523314863 0.0296322478724648 no 3239 0.0269639513553083 4665 2840958 SGTC_1403 3909-7815 62.9 µM -1.92895914750019 0.0295303237769189 no 3240 0.0268679670133536 4679 6615483 SGTC_1976 st070609 63.5 µM -1.93824458357482 0.0289234507691874 no 3241 0.0262966948972031 4632 682556 SGTC_2459 5811157 9.22 µM -1.93982660261966 0.0288210946390494 no 3242 0.026200383233906 4625 2870684 YBR192W RIM2 SGTC_1250 0485-0349 40.2 µM -1.94739084256983 0.0283358441311504 no 3243 0.025743947546838 4638 6842794 YDL195W SEC31 SGTC_2308 7584454 197.62 µM -1.97262303661333 0.026766098181117 no 3244 0.0242692632018794 4647 893577 SGTC_1619 st003326 88.7 µM -1.97725658746561 0.0264858766752637 no 3245 0.0240063170654639 4658 2849032 SGTC_1658 st012944 20 µM -1.98276688593341 0.0261558276822572 no 3246 0.0236967372351918 4548 24207260 SGTC_537 1334-0398 209 µM -1.98550607663078 0.0259930430752435 no 3247 0.0235440973605267 4698 5846986 SGTC_3287 9117173 37.0625 µM -1.98582008828365 0.0259744362540416 no 3248 0.0235266521937171 4706 2789709 SGTC_1188 1403-0014 4.57 µM -1.98591916347972 0.0259685678470332 no 3249 0.0235211502496275 4708 9614867 SGTC_1685 st024049 53.0905 µM -1.98809601863733 0.0258399083396738 no 3250 0.0234005358120811 4707 1941139 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.98830115757117 0.0258278114834716 no 3251 0.0233891964262794 4657 115019 SGTC_294 k038-0071 157 µM -1.99036729528457 0.0257062372466236 no 3252 0.0232752449210575 4699 24152826 SGTC_2700 st077718 96.8 µM -1.9976391921689 0.0252821527454473 no 3253 0.0228778955140596 4656 904970 SGTC_2769 toremifene 3.73 µM -2.00661778477592 0.0247666387256893 no 3254 0.022395188075052 4675 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.00699321377076 0.0247452766047961 no 3255 0.0223751927862286 4663 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_83 0170-0301 39.027 µM -2.00832141780313 0.0246698250799194 no 3256 0.0223045736825803 4704 3089716 SGTC_1677 st019204 53.9 µM -2.01509480943719 0.0242880436022218 no 3257 0.0219473580027317 4685 3945625 SGTC_686 1319-0111 510 µM -2.01669131277028 0.0241987829923764 no 3258 0.0218638685361505 4689 4562600 SGTC_1044 1222-0021 1.78 µM -2.0197480110608 0.0240286514646371 no 3259 0.0217047661419323 4614 4306703 SGTC_720 r052-1644 49.9 µM -2.02651171353579 0.0236557633211444 no 3260 0.0213561868020881 4680 1422863 YOR257W CDC31 SGTC_1840 st055363 71 µM -2.03208133200714 0.0233523706306713 no 3261 0.0210727114602374 4697 676033 SGTC_2354 9060492 162 µM -2.03627520196997 0.0231260858577065 no 3262 0.0208613642428729 4683 6471895 SGTC_1707 st032323 6.317 µM -2.03702686194508 0.0230857249647428 no 3263 0.0208236751066586 4524 3132057 YMR211W DML1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -2.03836821339745 0.0230138475566165 no 3264 0.0207565613522408 4680 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2847 9005661 71.43 µM -2.05147533142056 0.0223213591708819 no 3265 0.0201103397798824 4714 2991449 SGTC_3249 9135183 49.47 µM -2.05213859743212 0.0222867891966835 no 3266 0.0200780973994459 4668 4902779 SGTC_1954 st077032 68.9 µM -2.06225648062734 0.0217650120370026 no 3267 0.0195916619806691 4639 698907 SGTC_1666 st014829 29 µM -2.07255445949756 0.0212445811115693 no 3268 0.019106881498637 4719 3858230 SGTC_1269 0831-0796 3.05 µM -2.07730980964868 0.021007834372376 no 3269 0.0188864871335057 4699 927758 SGTC_3083 9117465 49.47 µM -2.086472379106 0.0205579647943744 no 3270 0.0184679273245339 4666 16420915 SGTC_1756 st041558 35.5 µM -2.09779642425938 0.0200132708833501 no 3271 0.0179615662673344 4743 3955792 SGTC_3084 9116877 49.47 µM -2.10380903180932 0.0197290702157694 no 3272 0.0176975543194403 4679 27241325 SGTC_2361 9034121 116 µM -2.12008533135429 0.0189768674208698 no 3273 0.0169994248820573 4719 6496917 SGTC_1733 st037357 54.9 µM -2.12062010783081 0.0189525726086743 no 3274 0.0169768922958036 4648 1272339 YGL099W LSG1 SGTC_2073 5212005 126 µM -2.13195716239609 0.018443723364938 no 3275 0.0165051841550299 4677 691789 SGTC_466 geldanamycin 89.2 µM -2.13220272768314 0.0184328314930206 no 3276 0.0164950921666778 4742 5288382 HSP90 inhibitor. SGTC_171 k064-0041 9.68 µM -2.1325817224043 0.0184160322063839 no 3277 0.0164795270007533 4688 53325 SGTC_280 3448-3607 3.04 µM -2.134546550156 0.0183291483246218 no 3278 0.0163990337017588 4698 626179 SGTC_80 0159-0065 512.242 µM -2.15151856910763 0.0175930839569483 no 3279 0.0157176458809307 4698 1548079 SGTC_2905 7799065 20.05 µM -2.15288749323051 0.0175348299893284 no 3280 0.0156637608238563 4649 1296806 SGTC_3132 9126706 49.47 µM -2.15951295936504 0.0172552078586203 no 3281 0.0154051965145795 4707 850858 SGTC_3333 9141820 12.094 µM -2.16683464793848 0.016950641757265 no 3282 0.0151237322501994 4694 1939433 SGTC_2310 7668677 200 µM -2.18512063719783 0.0162099920735925 no 3283 0.0144400012389035 4668 2197143 SGTC_2526 patulin 37.61 µM -2.19260979030915 0.015914754529569 no 3284 0.0141677525719458 4698 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_705 1124-0212 310 µM -2.20464735462567 0.015449871038854 no 3285 0.0137394250188639 4707 9554485 SGTC_1351 1496-0003 46.5 µM -2.21967711183857 0.0148858363164133 no 3286 0.0132203468064211 4737 3891978 SGTC_453 enantio-paf c16 10 µM -2.234415460082 0.0143500224782748 no 3287 0.0127278746987126 4283 13871343 A lipid and platelet activating factor SGTC_3068 9116768 49.47 µM -2.23937976715337 0.0141733235157041 no 3288 0.0125656083496481 4691 41904888 SGTC_514 4466-0038 2.65 nM -2.24501967364938 0.0139748549737721 no 3289 0.0123834348045664 4568 5722064 SGTC_430 0958-0115 16.4 µM -2.2521026943 0.0137290007287787 no 3290 0.0121578915430469 4679 6833180 SGTC_3047 9092122 49.47 µM -2.25832132582123 0.0135162347599798 no 3291 0.0119628168367822 4713 17173831 SGTC_395 anisomycin 6.25 µM -2.26636318960332 0.0132453132004291 no 3292 0.0117145777187378 4735 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1702 st027038 51 µM -2.2738970702295 0.0129957741613174 no 3293 0.0114860879508819 4768 5521182 SGTC_2408 sulbentine 18.36 µM -2.282246504572 0.0127239803517522 no 3294 0.0112373954556944 4626 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1854 st056233 32.9 µM -2.282287196525 0.0127226678689552 no 3295 0.0112361949764633 4704 5393174 SGTC_198 3454-2873 16.191 µM -2.29272149454107 0.012389961664318 no 3296 0.0109320221196761 4750 710957 SGTC_1814 st052110 31.539 µM -2.29653292812226 0.0122703240186764 no 3297 0.0108227143263893 4706 674163 SGTC_623 k072-0108 16.9 µM -2.3008558097699 0.0121358450961812 no 3298 0.0106998913124007 4737 5382803 SGTC_3201 9113999 49.47 µM -2.3056244338166 0.0119889834683307 no 3299 0.0105658133957115 4704 16649224 SGTC_1581 himbacine 57.9 µM -2.30994883472435 0.0118571378729355 no 3300 0.0104454934806668 4751 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2645 abamectin 100 µM -2.31948116112406 0.0115709444088498 no 3301 0.0101844807232137 4728 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3329 9141233 27.5565 µM -2.32225243814966 0.0114888746772739 no 3302 0.0101096734562161 4716 4909101 YNL103W MET4 SGTC_72 0744-0168 198.391 µM -2.33326484541291 0.0111677252686832 no 3303 0.00981712465480093 4680 677577 SGTC_2814 7977482 42.97 µM -2.34493477783342 0.0108359470640886 no 3304 0.00951520413319067 4724 6456762 SGTC_751 0833-0568 350 µM -2.34576783971565 0.0108125944969317 no 3305 0.00949396525999436 4739 6954252 SGTC_1881 5652484 16 µM -2.35223997502372 0.0106326538381584 no 3306 0.00933036581384744 4731 2255129 SGTC_635 k038-0028 24.7 µM -2.36003571781451 0.0104193813184994 no 3307 0.00913658779254338 4757 4035102 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.37916435675454 0.00991179896133493 no 3308 0.00867596863987789 4739 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1602 st001878 87.6 µM -2.3852779613012 0.00975419138732313 no 3309 0.00853311055237479 4730 595405 YLR310C CDC25 SGTC_1173 0443-0020 122 µM -2.38560471720907 0.00974582966284309 no 3310 0.00852553361006389 4749 5331295 SGTC_1831 st055328 12 µM -2.38817266472181 0.00968033327373911 no 3311 0.00846619227153577 4738 1103068 SGTC_1396 3511-0007 98.6 µM -2.38995334848493 0.00963514244746068 no 3312 0.00842525652130189 4749 X1396 SGTC_2436 5633522 8.09 µM -2.40838406278601 0.00917812545994285 no 3313 0.00801165733797897 4726 5724242 SGTC_2167 5876490 200 µM -2.41008927514967 0.00913681714269682 no 3314 0.00797430870462099 4738 686534 SGTC_2642 cholecalciferol 100 µM -2.42890445520324 0.00869172034402557 no 3315 0.00757226138389236 4761 9821465 A vitamin D precursor, similar to steriods. SGTC_1089 terbinafine 2.25 µM -2.43934432431097 0.00845304782863642 no 3316 0.00735697043077438 4764 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2884 9058502 51.95 µM -2.44839443052767 0.00825082204034275 no 3317 0.00717472369818315 4746 6471554 SGTC_1886 st057356 49.9 µM -2.44889833222002 0.00823968823855999 no 3318 0.00716469442471656 4755 24207747 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.47433828960008 0.00769446708029807 no 3319 0.00667416175395377 4757 756377 SGTC_97 0535-0701 19.132 µM -2.47900655015859 0.00759794182685672 no 3320 0.00658744433270861 4702 2832013 YGL099W LSG1 SGTC_1392 3455-1037 33.9 µM -2.48504606417642 0.00747464628195584 no 3321 0.00647673359402682 4761 981132 SGTC_664 1222-0054 14.9 µM -2.50170446408439 0.00714365790386405 no 3322 0.00617985254520283 4752 6813991 SGTC_3106 9121286 49.47 µM -2.55610200774394 0.00615110793367776 no 3323 0.00529260414914092 4742 15943471 SGTC_1744 st037937 38.9 µM -2.56109430247196 0.00606644882546928 no 3324 0.00521715145326339 4764 1016152 SGTC_2297 7971671 152.32 µM -2.57689495928647 0.00580526825341935 no 3325 0.00498461202404743 4751 909016 SGTC_2924 9010168 62.78 µM -2.62618951720008 0.00505339973991479 no 3326 0.00431733633950679 4749 2993929 SGTC_488 nitrendipine 139 µM -2.64251861322765 0.00482419027109384 no 3327 0.00411459710105622 4768 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1060 3448-7350 82 µM -2.67142958086729 0.00444101025723302 no 3328 0.00377644590841753 4758 570178 SGTC_2207 7258803 200 µM -2.71282072407007 0.00393972424603039 no 3329 0.00333565940051634 4780 3666799 SGTC_2015 5119600 184 µM -2.78191930680093 0.00321487441301817 no 3330 0.00270192371121603 4760 2828786 SGTC_2928 9011484 9.79 µM -2.85566508010396 0.00257570163141832 no 3331 0.00214733951234052 4755 2994751 SGTC_1524 corynanthine 62.1 µM -2.86775095463226 0.00248266674524769 no 3332 0.00206700402250727 4793 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_58 0957-0393 9 µM -2.8755426626386 0.00242430989866268 no 3333 0.00201666817630385 4420 6997992 SGTC_736 0958-0254 92.6 µM -2.89648318784644 0.00227357247816637 no 3334 0.00188685430914925 4789 6812352 SGTC_825 1988-2224 89.6 µM -2.91177774855194 0.00216889798316661 no 3335 0.0017968912107033 4782 1180859 SGTC_2953 9074162 66.49 µM -2.92059198613185 0.00211057780371089 no 3336 0.001746835216247 4773 16451992 SGTC_164 4100-3994 89.624 µM -2.94869839453262 0.0019339838383205 no 3337 0.00159557620247634 4766 4615967 SGTC_1711 st032263 62.8 µM -2.99997311221168 0.00164601730568822 no 3338 0.0013500171990382 4797 3958979 SGTC_1786 berberine 21.6 µM -3.04430746875836 0.0014291271645802 no 3339 0.00116608326534377 4745 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_76 0433-0009 400.328 µM -3.06546177989284 0.00133512474180611 no 3340 0.00108667076516 4793 2841569 SGTC_439 amiodarone 34.4 µM -3.06741394381144 0.00132674123342284 no 3341 0.00107959811002476 4741 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2521 angolensin 13.4 µM -3.07294883261535 0.00130323274696499 no 3342 0.00105977413432164 4797 821428 A flavenoid. SGTC_1129 3453-1384 223 µM -3.09183389455703 0.00122585930462949 no 3343 0.000994620632907994 4776 1084452 SGTC_2044 5102272 200 µM -3.21609675286273 0.000812961412705644 yes 3344 0.000649735068338758 4798 592666 SGTC_1106 tegaserod maleate 11.7 µM -3.22132831933587 0.000798781782726668 yes 3345 0.000637989418154687 4804 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2024 5144227 134 µM -3.22751671224803 0.000782302855904848 yes 3346 0.000624348732945243 4780 3475211 SGTC_3044 9093193 49.47 µM -3.25065051052041 0.000723434088243663 yes 3347 0.000575706519650719 4781 25236277 SGTC_2584 androsterone 48.74 µM -3.4308532826621 0.000386866724021536 yes 3348 0.000300842965859339 4764 2754130 A steroid. SGTC_1861 st057647 17.4 µM -3.59409252194539 0.000213940231291435 yes 3349 0.000162762077761076 4801 688668 SGTC_1621 st003705 32.4 µM -3.67121606792048 0.00016035651450125 yes 3350 0.000120699576269735 4801 24207032 SGTC_1827 berberine 7.24 µM -3.67290694755237 0.000159336478254073 yes 3351 0.000119903412791502 4785 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2582 agaric acid 100 µM -3.76232515182681 0.000113277596860525 yes 3352 8.41704964619135e-05 4688 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2415 st077333 57.7 µM -3.76445498029502 0.000112350796793776 yes 3353 8.34563675012986e-05 4803 2766255 SGTC_135 0933-0004 26.348 µM -3.7949710745352 9.98293764883007e-05 yes 3354 7.38303351582694e-05 4797 21230617 YGL099W LSG1 SGTC_2009 4012297 12.05 µM -4.0250323086044 3.98534684558931e-05 yes 3355 2.84837468198544e-05 4800 45595307 SGTC_1522 st012842 45.6 µM -5.25757815092666 1.26703400338866e-07 yes 3356 7.29824358679319e-08 4808 3491067 YOR116C RPO31