SGTCid condition conc unit DDI1|YER143W.score DDI1|YER143W.strain.pval DDI1|YER143W.strain.significant DDI1|YER143W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1897 st060201 15 µM 5.14717203939212 1.45759195902742e-08 yes 1 1.32221389973098e-07 10 611878 SGTC_919 tnp00227 403.569 nM 4.90402438791027 6.21301202492763e-08 yes 2 4.69464122197018e-07 13 1269246 A methoxyflavone. YNL221C POP1 SGTC_2952 9073731 13.78 µM 4.39498454687847 1.04678609304643e-06 yes 3 5.53903170861562e-06 25 16457353 SGTC_969 1313-0238 134 µM 4.23369459223996 2.41379087586917e-06 yes 4 1.14941543714316e-05 18 5212874 SGTC_2520 obtusaquinone 4.71 µM 4.01005727450358 7.33407409775327e-06 yes 5 3.03520106319837e-05 18 5967872 SGTC_2702 st077768 96.8 µM 3.9995896971007 7.71533782871829e-06 yes 6 3.17261978461112e-05 15 6484119 SGTC_1460 k062-0059 9.15 µM 3.81177525589129 1.87695170780627e-05 yes 7 6.89861492596653e-05 18 1373085 SGTC_3303 9125618 40.5795 µM 3.79063674942426 2.06949729890739e-05 yes 8 7.5130787787686e-05 52 22695467 SGTC_1349 flufenamic acid 69 µM 3.61599787948547 4.55194844568115e-05 yes 9 0.000149596411877571 22 3371 A non-steroidal anti-inflammatory. SGTC_263 alizarin 107.927 µM 3.59297697368975 5.03793646355882e-05 yes 10 0.000163460743650121 76 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2754 granisetron 64.02 µM 3.53296395505028 6.54529955075657e-05 yes 11 0.000205464246969264 45 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1288 0973-0013 65.5 µM 3.413321725791 0.000109021940288199 yes 12 0.000320880655244982 32 4315430 SGTC_2526 patulin 37.61 µM 3.40692885114381 0.000111986361910896 yes 13 0.000328491252392849 131 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3083 9117465 49.47 µM 3.40180308452898 0.000114417696757318 yes 14 0.000334714268004755 39 16420915 SGTC_1285 0929-0069 65.5 µM 3.2973843174407 0.00017613437630949 yes 15 0.000487949332831224 43 1206237 SGTC_2727 riluzole 51.77 µM 3.2600540465749 0.000204921454417471 yes 16 0.000556954927342681 27 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3349 9149703 23.001 µM 3.2495675042937 0.000213765988678102 yes 17 0.000577903213975311 34 4910494 SGTC_995 3931-2021 34.6 µM 3.24709738670025 0.000215900570077567 yes 18 0.000582942442974528 43 730143 SGTC_754 3474-0146 171 µM 3.23672470522556 0.000225083332494198 yes 19 0.000604549961467596 52 24762078 SGTC_2191 5911152 200 µM 3.22113645239245 0.000239571051821577 yes 20 0.000638416702560404 37 2875902 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 3.1574059113475 0.000308329767778631 yes 21 0.000795897984067745 50 4330530 SGTC_910 3454-3003 490 µM 3.10189031762388 0.000382764843372019 yes 22 0.00096144594960953 57 820824 SGTC_3233 9132340 49.47 µM 3.0959422721051 0.000391660279012157 yes 23 0.000980942762451116 53 17682950 SGTC_2411 st077133 39.94 µM 3.03918871328293 0.000486726087276679 yes 24 0.00118608104736948 96 1403142 YNL221C POP1 SGTC_2699 st077704 54.6 µM 3.0218452053339 0.000519789035214837 yes 25 0.00125619494640223 97 645852 SGTC_860 0443-0016 25.1 µM 3.00432556416335 0.000555287641423423 yes 26 0.00133085169306236 63 5337942 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.98546849757493 0.000595991878165726 yes 27 0.00141572150290209 88 5282362 SGTC_3137 9097352 49.47 µM 2.97423051004797 0.000621543115526187 yes 28 0.00146862166793854 95 44120435 SGTC_3188 9110789 49.47 µM 2.97271363634451 0.000625068403755165 yes 29 0.00147589853816101 74 849217 SGTC_2521 angolensin 13.4 µM 2.86765564001906 0.000919310948305644 yes 30 0.00206762676854123 50 821428 A flavenoid. SGTC_3340 9146634 11.102 µM 2.85241521532201 0.000971277262252755 yes 31 0.00216941925790159 63 4907387 SGTC_3325 9138760 55.175 µM 2.83589130527962 0.00103065722305819 no 32 0.00228489978695847 72 43844959 SGTC_2133 5320837 200 µM 2.82573056976886 0.00106880559327991 no 33 0.00235864620798618 89 2841355 SGTC_1038 k292-0204 154 µM 2.7633587306164 0.00133275834680216 no 34 0.00286049257042112 63 4454212 SGTC_2801 7907800 81.82 µM 2.73502985183244 0.00147128499811794 no 35 0.00311873095503315 115 6620925 SGTC_1386 3228-0095 33.8 µM 2.71046097414303 0.00160193191165242 no 36 0.00335948774514436 68 870181 SGTC_2864 9034755 47.6 µM 2.69566733048823 0.00168561194775074 no 37 0.00351238924966791 74 4930451 SGTC_1011 4112-3381 17.4 µM 2.68361569085013 0.00175670278303379 no 38 0.00364153859689138 110 2877139 SGTC_135 0933-0004 26.348 µM 2.64958132766395 0.00197244348682156 no 39 0.00402957863716866 97 21230617 YGL099W LSG1 SGTC_3006 9075424 71.4286 µM 2.63130073242598 0.00209800464200664 no 40 0.00425293657973396 88 7465181 SGTC_3341 9147222 25.867 µM 2.62717132013013 0.00212735311998245 no 41 0.00430489870025145 76 1939759 SGTC_933 2914-0560 114 µM 2.60359905653556 0.00230213035690132 no 42 0.00461253026848643 115 463887 SGTC_652 0437-0092 114 µM 2.58166091233868 0.00247636820553295 no 43 0.00491630707061347 82 3091274 SGTC_1907 st060210 83.7 µM 2.56505386995812 0.00261610290727427 no 44 0.00515798937321627 120 688793 SGTC_2596 sinensetin 100 µM 2.50538347345923 0.00317889213908959 no 45 0.00611593479913198 123 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_986 1493-0483 84 µM 2.50383717697744 0.00319482535475817 no 46 0.00614272787619945 91 40079 SGTC_2583 asiatic acid 100 µM 2.49531580881936 0.00328392661021163 no 47 0.00629225356529242 114 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1419 3993-2473 62.6 µM 2.48588873400204 0.00338509648973521 no 48 0.00646141813458404 104 704026 SGTC_2927 9011802 47.9 µM 2.48368491774379 0.00340914778844056 no 49 0.00650154016330971 129 43912568 SGTC_3195 9113082 49.47 µM 2.47355696784541 0.00352166497338256 no 50 0.00668877371152172 99 17018038 SGTC_3343 9148379 18.9835 µM 2.46960236920736 0.00356649647065508 no 51 0.00676316554417702 88 1955036 SGTC_684 1140-0066 328 µM 2.45968927048941 0.00368113681638223 no 52 0.00695286765426007 164 6813534 SGTC_2926 9010726 65.15 µM 2.44647204499194 0.00383912710372432 no 53 0.00721309921482653 139 2994293 SGTC_3252 9135871 49.47 µM 2.40255251599942 0.00440867942939453 no 54 0.00814054832203756 112 17682838 SGTC_1697 st025554 27.742 µM 2.39460803547509 0.00451941501864268 no 55 0.00831907052678893 106 1269519 SGTC_3304 9125678 46.087 µM 2.36449124986164 0.00496209585704491 no 56 0.00902742692627158 179 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3334 9142812 21.919 µM 2.36310305201146 0.00498340162227327 no 57 0.00906131472479493 130 45283678 SGTC_1664 st014217 9.02 µM 2.35427762901129 0.00512076829813909 no 58 0.00927937205874835 123 3982782 SGTC_72 0744-0168 198.391 µM 2.34944880048151 0.00519734637500216 no 59 0.00940061481133815 142 677577 SGTC_1986 st071812 45 µM 2.34501242079685 0.00526859719432735 no 60 0.00951322287557289 92 11838594 SGTC_758 0868-0029 16 µM 2.33443875828833 0.00544193089559461 no 61 0.00978637965442803 112 762687 SGTC_2109 5483026 200 µM 2.33280149202564 0.00546921896798227 no 62 0.00982928316851675 158 759335 SGTC_2747 doxorubicin 7.63 µM 2.33080514023369 0.00550265634565491 no 63 0.00988181847988046 52 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_763 3453-1109 128 µM 2.32615145210978 0.00558130826393416 no 64 0.0100052362614574 141 1560353 SGTC_1181 1222-0449 220 µM 2.30725101114942 0.00591110300087166 no 65 0.0105204154094101 151 658318 SGTC_286 k060-0067 22.9 µM 2.2975749662637 0.00608653877090112 no 66 0.0107929959060252 140 5985051 SGTC_1256 0570-0116 285 µM 2.29663038118711 0.00610390973568632 no 67 0.0108199319964169 154 410638 SGTC_1525 8-methoxypsoralen 92.5 µM 2.2867691827538 0.00628789753224561 no 68 0.0111046495743356 169 4114 Related to psoralen; DNA damaging agent. SGTC_550 4123-0385 25.7 µM 2.28242313158862 0.00637053218277438 no 69 0.0112321854777638 161 5731123 SGTC_1951 sophoraflavanone G 9.2 µM 2.2779074560574 0.00645740874929375 no 70 0.0113660459793755 162 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2483 5729050 27.16 µM 2.27564228255699 0.00650138165255292 no 71 0.0114337142297121 191 2865180 SGTC_3350 9150499 3.57 µM 2.27187123887742 0.00657517512248454 no 72 0.011547144253285 210 4910996 YPR165W RHO1 SGTC_2178 5812956 200 µM 2.26943003163837 0.00662333977416735 no 73 0.0116210938186024 151 5403383 SGTC_2678 equilin 100 µM 2.26799691767648 0.00665175996989108 no 74 0.0116646972721966 160 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2524 avocatin b 10.57 µM 2.26321264672546 0.00674741939883641 no 75 0.011811291999881 122 6710748 SGTC_1564 D-Arginine 115 µM 2.26318679638946 0.00674793954983549 no 76 0.0118120884016989 168 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2676 harmalol 100 µM 2.25837816017166 0.00684531563220658 no 77 0.0119610465694144 136 5459187 A monoamine oxidase inhibitor SGTC_140 0062-0056 502.533 µM 2.25813147265163 0.00685034441696585 no 78 0.0119687320007615 168 3758964 SGTC_1367 1812-0510 76.9 µM 2.22967645468457 0.00745275753809686 no 79 0.0128844650512617 171 1142582 YDR527W RBA50 SGTC_890 0929-0006 47.2 µM 2.22716026677286 0.00750820859786251 no 80 0.0129682822833191 149 1378169 SGTC_2738 aclarubicin 5.55 µM 2.21816679921865 0.00770938631048144 no 81 0.0132717307868352 103 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1069 diphenylcyclopropenone 8.49 µM 2.21744143863404 0.0077258170165561 no 82 0.013296470329646 201 65057 A dermal irritant. YDR527W RBA50 SGTC_1892 st058411 7.36 µM 2.20741936789037 0.00795600963636837 no 83 0.013642387251712 184 3934738 SGTC_1257 0669-0121 16 µM 2.18836620792991 0.00841031270374029 no 84 0.0143214688529133 191 4307855 SGTC_2593 nobiletin 86.24 µM 2.16801382487859 0.00892059811484521 no 85 0.0150788173435432 173 72344 An anti-infammatory. SGTC_1985 st071382 65.5 µM 2.16654864378537 0.00895835928371328 no 86 0.0151346434685597 164 6123237 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.16260950750119 0.00906057524700655 no 87 0.0152856131940419 160 803109 SGTC_1407 3909-7909 12.3 µM 2.1573274017782 0.00919924194868528 no 88 0.0154900817031296 179 4411780 SGTC_308 4092-1169 104 µM 2.15217135012085 0.00933638749420592 no 89 0.0156919306133644 221 2268590 YDL196W YDL196W SGTC_2965 9082772 38.63 µM 2.14950361535083 0.00940804611182547 no 90 0.0157972499034484 201 16459634 SGTC_2011 4012611 177 µM 2.14385118608278 0.00956146843203 no 91 0.0160224062488916 206 2049887 SGTC_2675 theaflavin digallate 100 µM 2.13663290786509 0.00976056894979936 no 92 0.016313930431011 189 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_283 0987-0079 11.7 µM 2.09663561937815 0.0109307456681638 no 93 0.0180129218189164 221 411556 SGTC_981 1488-1094 54.9 µM 2.0897075090277 0.0111453857496692 no 94 0.0183220410331343 144 3449522 SGTC_1258 0671-0043 57.1 µM 2.08954607661748 0.011150430481871 no 95 0.0183292973903813 231 4298767 SGTC_1351 1496-0003 46.5 µM 2.08797580052381 0.0111996049885236 no 96 0.0184000088340226 181 3891978 SGTC_3265 9137266 49.47 µM 2.08463111105893 0.0113049755902121 no 97 0.0185513991093622 140 17224265 SGTC_2228 7354201 200 µM 2.0800388041513 0.0114510539878673 no 98 0.0187609869066119 122 753451 SGTC_324 1315-0088 19.6 µM 2.06070971523438 0.012084018551095 no 99 0.0196653711123842 149 6787421 SGTC_1720 st037298 9.481 µM 2.05634680078621 0.0122310151207923 no 100 0.0198745501039657 218 597396 SGTC_389 tpck 16.7 µM 2.05485005188163 0.0122817997612571 no 101 0.0199467450439874 212 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2220 6782180 200 µM 2.05091761972087 0.0124160985013292 no 102 0.0201374849783658 110 833803 SGTC_2462 5162487 171.77 µM 2.04872800246721 0.012491427203833 no 103 0.0202443597045766 193 2259986 SGTC_1724 st037281 8.293 µM 2.02987201224457 0.0131566625920409 no 104 0.0211847753248298 250 574124 YDL195W SEC31 SGTC_3312 9133330 71.43 µM 2.02760399089667 0.0132387043621877 no 105 0.0213003406865857 183 17617324 SGTC_1230 0170-0365 3.77 µM 2.01698850643811 0.0136286027465749 no 106 0.0218483563817091 353 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_256 clotrimazole 625 nM 1.99991016253825 0.014276672103156 no 107 0.0227549827953361 249 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3275 9138069 49.47 µM 1.99426505729975 0.0144966439029924 no 108 0.023061547883751 176 17617007 SGTC_1481 3346-2004 36 µM 1.99383093094894 0.0145136805875937 no 109 0.0230852670497047 205 2770522 SGTC_985 1493-0307 8.71 µM 1.97595875323596 0.0152301659852474 no 110 0.0240797244771037 167 3278274 SGTC_2889 9059656 51.95 µM 1.97070647714641 0.0154464195640637 no 111 0.0243787296251259 206 3949838 SGTC_559 1550-0661 158 µM 1.94955786038686 0.0163440574364426 no 112 0.0256144200630972 214 5830875 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.94920863661184 0.0163592472404252 no 113 0.0256352569924507 178 688803 SGTC_1410 3909-8106 77.9 µM 1.93996386677425 0.0167657754152186 no 114 0.0261920406589772 182 1039210 SGTC_1051 3253-3903 78 µM 1.93732011769301 0.0168836083975981 no 115 0.0263531122898572 269 5509239 SGTC_2345 9052315 157.45 µM 1.93567534943234 0.0169572731667795 no 116 0.0264537377007395 243 6469265 SGTC_1817 st052116 64.4 µM 1.93438001303839 0.0170154810803084 no 117 0.0265332110152796 220 4361398 SGTC_3276 9139060 49.47 µM 1.93340875253687 0.0170592381217871 no 118 0.026592931945362 161 4870619 SGTC_1060 3448-7350 82 µM 1.93030615999952 0.0171996604269151 no 119 0.0267844571257518 256 570178 SGTC_3321 9137793 26.8275 µM 1.92741418196329 0.0173314385384903 no 120 0.0269640168043234 291 4904192 SGTC_2037 5169046 200 µM 1.92179249599868 0.0175900692782565 no 121 0.0273159364650419 210 5718022 SGTC_78 0336-0123 156.75 µM 1.91479256579606 0.0179167057142374 no 122 0.0277594814719988 215 6765896 SGTC_1945 st075991 56.6 µM 1.91028011112406 0.0181300002415848 no 123 0.0280485785831397 234 1084980 SGTC_1202 1988-0068 29.6 µM 1.90284403185484 0.0184862101689048 no 124 0.0285304498901221 266 2850480 SGTC_1325 1431-0015 227 µM 1.89823408484356 0.018710019258469 no 125 0.0288326263240795 224 1103340 SGTC_536 3852-0578 10.6 µM 1.89712689165314 0.0187641147140931 no 126 0.0289055963984154 234 2869208 SGTC_849 0386-0493 241 µM 1.89544633009238 0.01884647821197 no 127 0.0290166478471333 220 726119 SGTC_274 sirtinol 40.1 µM 1.89484173360082 0.0188761843273136 no 128 0.0290566861807238 240 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1860 st056228 74.6 µM 1.89465036207788 0.0188855954308296 no 129 0.0290693689822203 243 688679 SGTC_3209 9113616 49.47 µM 1.88664512820266 0.0192828613058795 no 130 0.0296040363089311 263 16649353 SGTC_947 3447-0010 211 µM 1.88531850233786 0.0193493773891276 no 131 0.0296934248058861 229 748350 SGTC_2858 9025781 8.96 µM 1.87818383792282 0.0197104574169111 no 132 0.0301780101759336 389 4894980 YPL153C RAD53 SGTC_2962 9082311 13.18 µM 1.87110754967905 0.0200742173479826 no 133 0.0306650876836533 234 16459453 SGTC_530 4358-1714 28 µM 1.87104217542007 0.0200776043105716 no 134 0.0306696177178301 317 1564641 SGTC_2665 lovastatin 100 µM 1.87033724831448 0.0201141565469075 no 135 0.0307185000448562 250 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2570 licareol 100 µM 1.86916400912965 0.0201751170667366 no 136 0.0307999999323374 274 443158 SGTC_3123 9126162 49.47 µM 1.8667360593438 0.0203017689863612 no 137 0.0309692277572837 238 25239884 SGTC_2096 5468907 200 µM 1.86100014982923 0.0206036571054055 no 138 0.0313720777675892 237 759785 SGTC_446 go6976 132 µM 1.85825192711376 0.020749641682368 no 139 0.0315666235334335 213 3501 A protein kinase C inhibitor. SGTC_2913 7966556 36.57 µM 1.84607785334815 0.0214069009070279 no 140 0.0324404510038244 229 2976516 SGTC_1963 st076565 50.3 µM 1.83878265698967 0.0218091277269704 no 141 0.0329735800626805 235 4914280 SGTC_73 0327-0325 16.231 µM 1.83720166838464 0.0218971334178577 no 142 0.0330900647411613 338 53298 SGTC_203 k066-0004 30.888 µM 1.83181434517808 0.022199273836065 no 143 0.0334895426362403 334 6795412 SGTC_2173 5763948 167 µM 1.83025526439015 0.0222873662803301 no 144 0.0336058887124293 267 2867177 SGTC_2983 9022671 12.99 µM 1.82997554134802 0.0223032025806133 no 145 0.0336267981425459 249 6405161 SGTC_3201 9113999 49.47 µM 1.82153362145914 0.0227856206951633 no 146 0.0342628903521483 287 16649224 SGTC_1837 st055472 66.5 µM 1.81677070025229 0.0230616596940094 no 147 0.0346261154750609 282 676091 SGTC_2611 pyromycin 23.93 µM 1.79488201215543 0.0243667067137219 no 148 0.036336250219927 309 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1478 0453-0656 35.7 µM 1.79342341576347 0.0244558317723276 no 149 0.036452623104751 281 5258496 SGTC_2720 fluspirilene 36.88 µM 1.79148507273254 0.0245746942393033 no 150 0.036607743953687 217 3396 An atypical antipsychotic. SGTC_2095 5432005 200 µM 1.78776075526578 0.0248044365108765 no 151 0.0369073074899952 253 783734 SGTC_364 0083-0097 67.7 µM 1.78600112320056 0.0249136081383439 no 152 0.0370495381372799 284 5207356 SGTC_1000 4048-0884 8.67 µM 1.78547343859915 0.0249464253323804 no 153 0.0370922779741633 306 13040088 SGTC_1059 3448-6867 171 µM 1.7783504681589 0.0253929676115585 no 154 0.0376731561614914 284 3934407 SGTC_1761 st044296 37 µM 1.77002874188018 0.0259231214287837 no 155 0.0383611764209927 289 1826700 SGTC_2060 5238662 140 µM 1.7666269151457 0.0261424930724869 no 156 0.0386453651848993 288 790130 SGTC_3346 9158254 43.5805 µM 1.76439012732039 0.0262875797987011 no 157 0.0388331596037916 305 17639500 SGTC_1149 3909-7961 23.3 µM 1.75723406535693 0.0267562783817926 no 158 0.0394389605332154 301 735261 SGTC_2044 5102272 200 µM 1.7545274314941 0.0269353635809592 no 159 0.0396700868821507 247 592666 SGTC_2387 9077560 195.08 µM 1.75200772601824 0.0271029788544297 no 160 0.0398862397141615 315 5303272 SGTC_1911 st060208 74.3 µM 1.74993499559048 0.0272415122129657 no 161 0.0400647655889903 324 688783 SGTC_1620 st003704 16.5 µM 1.7478718619011 0.0273799902603371 no 162 0.0402431091030396 259 2834414 SGTC_3238 9133470 49.47 µM 1.7452149431831 0.0275591876209851 no 163 0.0404737305238276 250 3534688 SGTC_2621 lithochol-11-enic acid 100 µM 1.74505479514809 0.0275700200630165 no 164 0.0404876656430919 350 6708711 SGTC_2759 disulfiram 3.38 µM 1.74073160469656 0.0278637852805396 no 165 0.0408653178330185 315 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1632 st005650 90 µM 1.73595605040868 0.0281913155509209 no 166 0.041285802949533 305 2759605 SGTC_667 1498-1044 59 µM 1.73532745127502 0.0282346656228687 no 167 0.0413414110622307 314 6739982 SGTC_1941 st076221 61.8 µM 1.72444907997482 0.0289937016879014 no 168 0.042313401919318 394 2828568 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.72257498470779 0.0291261634341931 no 169 0.0424827059657903 294 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2552 juarezic acid 87.02 µM 1.71764102564178 0.0294773034393313 no 170 0.0429310561909745 379 1549512 SGTC_1294 1000-1494 117 µM 1.71715533044774 0.0295120586032224 no 171 0.0429753974008155 308 712797 YDL207W GLE1 SGTC_3222 9128301 49.47 µM 1.71594036970736 0.0295991472275747 no 172 0.0430864784789728 305 4911358 SGTC_3256 9138902 49.47 µM 1.71581094909295 0.0296084366801865 no 173 0.0430983247662186 215 17228773 SGTC_1633 st005664 67.9 µM 1.71087138600916 0.0299647974241803 no 174 0.0435524289348341 348 2063822 SGTC_1509 1326-1131 80 µM 1.70872543534429 0.0301207198522749 no 175 0.0437509101510203 284 768313 SGTC_264 promethazine 12.5 mM 1.70034448789363 0.0307361270799145 no 176 0.0445330734756047 452 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1326 1431-2094 10.8 µM 1.69767860595581 0.0309340498201619 no 177 0.0447842188927494 362 616278 SGTC_337 1315-0038 354 µM 1.69615672484512 0.0310475108273667 no 178 0.0449281017227934 305 1626437 SGTC_792 4534-1957 155 µM 1.68805305145707 0.0316574777245339 no 179 0.0457005227947039 305 1717904 SGTC_1462 k081-0014 26.5 µM 1.68504910141924 0.0318860875791174 no 180 0.0459895492643636 217 3270634 SGTC_631 k072-0230 41.5 µM 1.6821392925511 0.0321088314554325 no 181 0.0462709163245389 348 5773147 SGTC_1244 0416-0015 52.5 µM 1.67937661145283 0.0323215001043452 no 182 0.0465393342797744 344 96201 SGTC_323 4013-0906 34.3 µM 1.67765960120654 0.0324542587243353 no 183 0.0467067851509527 286 2910086 SGTC_2657 nystatin 74.44 µM 1.66911439176367 0.0331216784055265 no 184 0.0475473558206119 335 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_252 miconazole 1.30953 nM 1.66344851846171 0.0335704126546648 no 185 0.0481113439579633 331 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1510 1123-0200 71.5 µM 1.65898947687453 0.0339270748874663 no 186 0.0485589564015075 414 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1337 1486-1011 40.3 µM 1.65833477092808 0.0339797038500654 no 187 0.0486249572551262 307 X1337 SGTC_975 1335-0046 28.5 µM 1.6517225924943 0.0345150005314476 no 188 0.0492955574410181 380 16486740 SGTC_1387 3342-1166 1.8 µM 1.65157029064487 0.0345274114637115 no 189 0.0493110903026917 232 3418228 SGTC_630 4356-0227 183 µM 1.64665148974064 0.0349302151650021 no 190 0.0498148502690283 316 779312 SGTC_1 0258-0098 57.368 µM 1.64523310626069 0.0350470813704919 no 191 0.0499608743715166 291 6790032 YDR047W HEM12 SGTC_2993 9054257 71.4286 µM 1.64067044140944 0.0354251953123321 no 192 0.0504329219603126 401 6470217 YGL055W OLE1 SGTC_2653 dihydrofissinolide 100 µM 1.63895682432372 0.0355680663103161 no 193 0.0506111259615623 284 6857746 SGTC_739 1486-1183 203 µM 1.63484455958908 0.0359128495464921 no 194 0.0510408184881831 349 4346692 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.63377339746115 0.036003106722285 no 195 0.0511532200763518 384 4174840 SGTC_1323 1348-1351 11.2 µM 1.63134023816556 0.0362088175654673 no 196 0.0514092736793901 313 6989654 SGTC_1393 3470-5649 58.2 µM 1.63057861282288 0.0362734063929703 no 197 0.0514896325062765 278 4108395 SGTC_1523 st012844 44.7 µM 1.62891468937947 0.0364148417813362 no 198 0.0516655399901836 372 4274103 SGTC_1267 0828-0272 9.49 µM 1.62558892527535 0.0366988881070263 no 199 0.0520185663530502 390 745334 SGTC_1416 3966-0321 25.3 µM 1.62533029768879 0.0367210526644192 no 200 0.0520460995140925 363 582530 YLR208W SEC13 SGTC_3320 9137005 35.139 µM 1.62514506333216 0.0367369341008773 no 201 0.0520658264405166 325 4908713 SGTC_2255 7941087 197.44 µM 1.61837391384461 0.037321338732612 no 202 0.0527910201497402 402 935561 SGTC_1299 1079-1439 3.74 µM 1.61311572425962 0.0377803828457471 no 203 0.0533596841345066 337 323161 SGTC_1518 st038567 90.8 µM 1.61221127378491 0.0378598046672073 no 204 0.0534579864212536 308 77966 SGTC_2774 tamoxifen 10.92 µM 1.60495773788363 0.0385016933672084 no 205 0.0542515528323386 364 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1372 2752-0194 270 µM 1.59940498645146 0.0389990450064317 no 206 0.0548653225215119 343 823334 SGTC_1802 st050112 57.9 µM 1.59742792688134 0.0391773851739087 no 207 0.0550851757300773 353 4662563 SGTC_3264 9137442 49.47 µM 1.59117650706932 0.0397456649425573 no 208 0.0557849291982563 325 17015726 SGTC_1449 4112-4002 201 µM 1.5868931407077 0.0401388961088881 no 209 0.0562684243606132 367 2059539 SGTC_268 camptothecin 39.6153 µM 1.58340872940672 0.0404611060767536 no 210 0.0566641673064605 496 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1022 4477-0945 21.3 µM 1.57974536705027 0.0408021252709865 no 211 0.0570825957984361 388 4648966 SGTC_1915 st067105 30.6 µM 1.57292404831108 0.0414433281366807 no 212 0.0578682029700757 404 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2151 5563267 85.4165 µM 1.56924197198733 0.041792821751645 no 213 0.0582957838547151 402 5310824 SGTC_2288 7946289 167.31 µM 1.56673935933518 0.0420317231535744 no 214 0.0585878134087673 448 1246052 SGTC_707 0865-0008 204 µM 1.56298271347504 0.0423924094310135 no 215 0.059028330421862 378 723043 SGTC_314 1671-0008 2.74 µM 1.56071713852719 0.0426111412780733 no 216 0.0592952528339593 454 3913060 SGTC_1958 st076513 41.9 µM 1.56064196467264 0.0426184146135267 no 217 0.0593041257600433 417 732122 YGL099W LSG1 SGTC_1799 st045822 46.1415 µM 1.559217035816 0.0427564714450146 no 218 0.0594725100372142 366 3674992 SGTC_2265 7929201 200 µM 1.55914102785319 0.0427638457589984 no 219 0.0594815024387696 406 1265108 SGTC_569 4130-2812 160 µM 1.55883082515698 0.0427939523723636 no 220 0.0595182131604236 281 743552 SGTC_898 1000-0849 28.3 µM 1.55187205582421 0.0434738476136168 no 221 0.0603464202208426 374 6751807 SGTC_674 0498-0004 451 µM 1.55086953618601 0.0435725118433098 no 222 0.0604664761368002 406 4231473 SGTC_2279 7948423 32.93 µM 1.54913335237679 0.0437438079835451 no 223 0.0606748333910361 341 1247112 SGTC_1107 amlodipine 47 µM 1.5479389424205 0.0438619665395301 no 224 0.0608184987978327 420 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2758 dehydroepiandrosterone 69.35 µM 1.54729460107383 0.0439258156672099 no 225 0.0608961115140014 423 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3185 9108267 49.47 µM 1.54225845866371 0.0444274439425834 no 226 0.0615053996840435 414 4910486 SGTC_1748 st037455 53.6035 µM 1.5407243963616 0.0445811590924406 no 227 0.0616919383023743 417 580690 SGTC_827 3253-0474 693 µM 1.53927534471394 0.0447267492394108 no 228 0.0618685452046267 419 5402065 SGTC_1949 st076024 69.1 µM 1.53886737895223 0.0447678076671904 no 229 0.0619183382041028 422 2921930 SGTC_247 mechlorethamine 29.705 µM 1.53481541430839 0.0451772546530459 no 230 0.0624145876914683 325 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.53269050686702 0.0453931757679513 no 231 0.0626760646514761 417 5393153 SGTC_2352 9027995 87.8 µM 1.53236376092397 0.0454264513563124 no 232 0.0627163474564008 343 2997347 SGTC_651 3253-0966 34.4 µM 1.53065756595928 0.0456005279140642 no 233 0.0629270231970327 440 781462 SGTC_208 k072-0098 12.366 µM 1.52821332419902 0.0458508386103197 no 234 0.0632297908365787 500 5948901 SGTC_982 1491-0518 27.5 µM 1.5276379507631 0.0459099218997077 no 235 0.0633012268685947 367 3091256 SGTC_3036 9090181 49.47 µM 1.52478774354084 0.0462035033896845 no 236 0.0636560239660225 354 25236586 SGTC_1210 3013-0140 750 nM 1.52369760919285 0.0463161889337843 no 237 0.0637921334902389 404 905973 SGTC_2243 6634756 200 µM 1.51985913953416 0.0467147231416352 no 238 0.0642731908932715 345 885676 SGTC_854 0422-0053 192 µM 1.51963792665383 0.0467377744517498 no 239 0.064301000156222 404 3596728 SGTC_2887 9044784 58.44 µM 1.51933964034631 0.0467688715838372 no 240 0.0643385133302539 424 6465546 SGTC_1217 1183-1422 255 µM 1.51676826480118 0.0470376330385089 no 241 0.064662601040888 402 2849664 SGTC_3315 9136395 68.55 µM 1.50555225007101 0.0482244493256253 no 242 0.0660910770908544 427 16876844 SGTC_1019 4262-0212 3.4 µM 1.50300007571432 0.0484978245171255 no 243 0.0664195122343418 511 4677213 SGTC_864 0469-0573 172 µM 1.50186978707468 0.0486192902312523 no 244 0.0665653703712881 405 689425 SGTC_3051 9093778 49.47 µM 1.50157516645012 0.0486509913672567 no 245 0.0666034304063455 316 17217378 SGTC_2050 5263056 171 µM 1.49204906602281 0.0496849326273332 no 246 0.0678431414784917 502 763468 YGL055W OLE1 SGTC_1485 3909-9022 254 µM 1.49069420709809 0.0498333996691938 no 247 0.0680208988420927 429 714516 SGTC_1774 st048371 48.465 µM 1.48587989769833 0.0503638221655361 no 248 0.0686554458380371 456 4242727 SGTC_1494 4358-1428 177 µM 1.48286111222934 0.0506987091669394 no 249 0.0690556576322902 451 1564571 SGTC_2457 5731572 11.68 µM 1.48160176008606 0.0508389377546873 no 250 0.0692231452168428 396 2865357 SGTC_76 0433-0009 400.328 µM 1.47947466663405 0.0510764902703347 no 251 0.0695067486049028 352 2841569 SGTC_1154 4088-0362 150 µM 1.4769407766559 0.0513606256074471 no 252 0.0698457565999655 502 6618304 SGTC_192 3455-0609 60.9 µM 1.47181736340339 0.0519389750542667 no 253 0.0705351017412458 425 3769639 SGTC_2327 6189656 200 µM 1.47027043152165 0.0521146117786497 no 254 0.0707442629578315 403 5349088 SGTC_309 k408-0051 1.48 µM 1.46804562135778 0.0523680407727006 no 255 0.0710459155275528 535 3640463 SGTC_3110 9122132 49.47 µM 1.46425191199271 0.052802439491979 no 256 0.071562565493577 441 918317 SGTC_504 lovastatin 124 µM 1.46354213287423 0.0528840293200759 no 257 0.0716595467828238 363 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_223 busulfan 5 mM 1.46260529044469 0.0529918733760179 no 258 0.0717877073961439 346 2478 A DNA alkylator. SGTC_2205 7238770 200 µM 1.45943706046957 0.053357875011972 no 259 0.0722224259622351 384 279867 SGTC_1319 1306-0155 43.7 µM 1.45577822762066 0.0537830419556592 no 260 0.0727269681977736 503 3122360 SGTC_2805 7950783 58.44 µM 1.45565178862473 0.0537977823519475 no 261 0.0727444518855883 514 1178958 YDL195W SEC31 SGTC_942 3253-1115 227 µM 1.45511877397191 0.0538599569557595 no 262 0.0728181912841466 441 46497897 SGTC_3042 9091578 49.47 µM 1.45506901881957 0.0538657636513173 no 263 0.0728250775320561 369 25236497 SGTC_2308 7584454 197.62 µM 1.4550270995607 0.0538706562404256 no 264 0.0728308796580424 498 893577 SGTC_2796 7949634 45.45 µM 1.45365650161824 0.0540308189354876 no 265 0.0730207817996983 439 2971588 SGTC_1787 fluconazole 80 µM 1.45332632492335 0.0540694583703797 no 266 0.0730665857701217 525 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2458 5808907 16.39 µM 1.45200246112938 0.0542246052640276 no 267 0.0732504604586617 440 2731747 SGTC_622 1348-1566 26.3 µM 1.45035000132232 0.0544187551717321 no 268 0.0734804711091928 491 7340407 SGTC_3247 9135149 49.47 µM 1.44914846288596 0.0545602706290359 no 269 0.0736480632274859 381 8934436 YOR116C RPO31 SGTC_1708 st033234 31.827 µM 1.44603047467377 0.0549288604146519 no 270 0.074084327218697 482 674664 SGTC_1156 4092-0367 4.88 µM 1.44316024177677 0.0552698989572754 no 271 0.0744876682435437 469 1357585 SGTC_19 0279-0214 38.434 µM 1.43965276208472 0.0556889226038072 no 272 0.0749828320794281 551 3566274 YBR002C RER2 SGTC_377 3970-0964 33.1 µM 1.43629184009336 0.0560927859097673 no 273 0.0754596574943805 555 16481235 SGTC_2479 5617353 43.85 µM 1.43580826819692 0.056151083651366 no 274 0.0755284532190765 455 2731746 SGTC_1482 3346-2049 8.48 µM 1.43554227829979 0.0561831708273675 no 275 0.0755663148435475 448 3826804 SGTC_2475 5812728 15.03 µM 1.43283387219846 0.05651071783644 no 276 0.0759526594208573 482 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_403 arphamenine a 50 µM 1.43168221584834 0.0566504510844236 no 277 0.0761173941473852 475 5487158 An arginine aminopeptidase inhibitor. SGTC_819 1013-0258 27.7 µM 1.4278439296126 0.0571181258062289 no 278 0.0766683926760822 478 5753198 SGTC_3161 9100388 49.47 µM 1.42602050972313 0.0573413620406681 no 279 0.0769312109731073 446 25236368 SGTC_3022 9087993 49.47 µM 1.42476712750376 0.0574952078690792 no 280 0.0771122637759312 399 17173644 SGTC_552 k242-0005 476 µM 1.42310573722691 0.0576996346835226 no 281 0.07735275272779 416 4088318 SGTC_782 0083-0095 30.5 µM 1.422886033479 0.0577267110054503 no 282 0.077384597806722 517 3591729 An indicator and reagent. SGTC_318 1488-0629 67.2 µM 1.41798700694463 0.0583330666941539 no 283 0.0780972791013552 436 3662576 SGTC_173 1273-0061 2.693 µM 1.41680319191254 0.0584803361160482 no 284 0.078270238118638 539 2847414 YPL266W DIM1 SGTC_977 1348-1378 135 µM 1.41389618406223 0.0588432135984565 no 285 0.0786961932654002 476 X977 SGTC_1821 st053465 65.6 µM 1.41269788162273 0.0589933092471932 no 286 0.0788722873590936 447 675086 SGTC_3294 9122953 26.2835 µM 1.41112040875515 0.0591913563733953 no 287 0.079104556606359 472 16459826 SGTC_3102 9121669 49.47 µM 1.40858348324543 0.0595109531032179 no 288 0.0794791827859833 414 41905072 SGTC_618 k072-0232 33.2 µM 1.40673308066752 0.0597449149218034 no 289 0.0797532762592508 445 5872756 YGL099W LSG1 SGTC_2906 7926292 26.41 µM 1.40662474208886 0.0597586353707051 no 290 0.0797693461920541 485 2966319 SGTC_2087 5276107 200 µM 1.40422609506847 0.0600630428252397 no 291 0.0801257667987234 452 144405 SGTC_1166 k206-0078 225 µM 1.40351273445777 0.0601538078404846 no 292 0.0802319986390298 512 5404595 SGTC_996 3970-0799 1.8 µM 1.40030016633441 0.0605638928859402 no 293 0.0807117255318957 635 6615648 YGL040C HEM2 SGTC_2594 a-mangostin 100 µM 1.39714396011756 0.060968910020397 no 294 0.0811851423296839 520 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2799 7812892 81.82 µM 1.39492797290287 0.0612545374450726 no 295 0.0815187803818953 525 20205235 SGTC_538 2922-0838 53.3 µM 1.39051335675315 0.0618266701075683 no 296 0.0821865231166032 573 777039 SGTC_1297 1068-0111 14.1 µM 1.38906566312487 0.0620151962018563 no 297 0.0824063919320442 459 767057 SGTC_1350 1495-0454 146 µM 1.38799757284334 0.0621545757341639 no 298 0.0825688920996279 558 1069057 SGTC_226 1,3-diallylurea 8.28947 mM 1.38684408744102 0.0623053731653841 no 299 0.0827446551284304 426 74537 YKL182W FAS1 SGTC_3172 9105863 49.47 µM 1.38368999207856 0.0627191712707526 no 300 0.0832266996433847 375 2348785 SGTC_2899 9053889 58.44 µM 1.38338183038751 0.0627597147883681 no 301 0.083273909385769 452 6470052 SGTC_2306 7482397 179.52 µM 1.38158745132336 0.0629961994089186 no 302 0.0835492045960357 506 891448 SGTC_1113 artemisinin 1.17947 µM 1.38090384006389 0.0630864762114918 no 303 0.0836542645460285 509 2240 An anti-malaria and mitochondrial poison. SGTC_2888 9058547 12.99 µM 1.37880954721925 0.0633636730104237 no 304 0.083976741158959 403 16476514 SGTC_2236 dapsone 200 µM 1.37703370331146 0.063599462526153 no 305 0.0842509139720066 502 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2844 9010103 25.97 µM 1.37472212762161 0.0639074064643683 no 306 0.0846088042073801 510 2480525 SGTC_3009 9080819 71.4286 µM 1.36799733160593 0.0648098671304286 no 307 0.0856564556785692 488 17027216 SGTC_1540 guanosine 70.6 µM 1.36525871509384 0.065180209676743 no 308 0.0860858749696535 455 6802 Guanosine is a purine nucleoside SGTC_2258 7960471 200 µM 1.36102247943738 0.0657563068767303 no 309 0.0867532928129678 394 2974708 SGTC_1607 st000305 50.6 µM 1.36101467330862 0.0657573720848203 no 310 0.0867545262256265 517 5457690 SGTC_672 1441-0018 53.7 µM 1.35870502122673 0.066073130266032 no 311 0.0871200401706422 473 251141 SGTC_3156 9099931 49.47 µM 1.3558835031286 0.066460459423015 no 312 0.0875681185812854 513 18111053 SGTC_1903 st060211 78.3 µM 1.35233641935158 0.0669498832600669 no 313 0.0881338594158395 525 688960 SGTC_2309 7664088 163.95 µM 1.34898265009514 0.0674151934678713 no 314 0.0886712694712447 570 704922 SGTC_1455 4262-0120 131 µM 1.34785614381622 0.0675720472620828 no 315 0.0888523280120262 530 1529587 SGTC_2038 4100038 30.985 µM 1.34698635956564 0.0676933480963784 no 316 0.0889923129275864 520 3596803 SGTC_2659 sanguinarine 24.21 µM 1.3455695998923 0.067891290645331 no 317 0.0892206806068147 508 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_837 0091-0265 12.5 µM 1.34378247876167 0.0681416154085774 no 318 0.0895093684699797 550 759367 SGTC_82 0054-0107 293.755 µM 1.34347614108642 0.068184596029612 no 319 0.0895589232941726 472 3104697 SGTC_197 4544-0043 41.561 µM 1.3413421118329 0.06848459124575 no 320 0.0899047015282729 562 896523 SGTC_2333 9017922 200 µM 1.33656361150901 0.0691600298316493 no 321 0.0906825617735108 513 3163164 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.33555107102529 0.0693038087756121 no 322 0.0908480259430053 517 115019 SGTC_2829 7992743 58.44 µM 1.33377678730474 0.069556309014536 no 323 0.0911385103069239 524 16462845 SGTC_1278 0874-0585 172 µM 1.33131466692402 0.06990786878813 no 324 0.0915427470913537 527 766306 SGTC_3196 9111891 49.47 µM 1.33069338301081 0.0699967959903172 no 325 0.0916449605937624 481 18891510 SGTC_262 fenpropimorph 62.5 µM 1.32892608556432 0.0702502332773142 no 326 0.0919361783802474 470 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3181 9108277 49.47 µM 1.32370995453634 0.071002362403026 no 327 0.0927996955712591 506 17097298 SGTC_2354 9060492 162 µM 1.3162769504752 0.0720848152714409 no 328 0.0940405521253584 598 6471895 SGTC_1884 5633444 25 µM 1.31194256296697 0.0727218367337792 no 329 0.0947697574893372 567 5724239 SGTC_1246 0422-0085 105 µM 1.30889766141576 0.0731719150504096 no 330 0.0952845094510831 594 264295 SGTC_1999 st074831 12.5 µM 1.30785128282605 0.0733270752799895 no 331 0.0954618780663597 563 17112523 SGTC_647 0140-0236 81 µM 1.30725729559272 0.0734152654434071 no 332 0.095562671195904 610 990837 SGTC_1195 1502-0147 41.1 µM 1.29713776359408 0.0749302193673244 no 333 0.0972918950176215 576 817940 SGTC_2342 7990637 118.86 µM 1.29496613678507 0.0752584109214443 no 334 0.0976659557307492 579 2033102 YER133W GLC7 SGTC_1596 piperlongumine 63 µM 1.29464360835405 0.0753072470142247 no 335 0.0977216007699693 599 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3323 9138564 53.9225 µM 1.2944572535831 0.0753354751914157 no 336 0.0977537626945452 603 43912313 YNL103W MET4 SGTC_1838 st055369 84.5 µM 1.29141522261583 0.0757974094593545 no 337 0.0982798674356881 493 676036 SGTC_2929 9013348 24.6 µM 1.29062849793581 0.0759172244698348 no 338 0.0984162646216674 551 2995952 SGTC_682 0kpi-0099 17 µM 1.27380824814158 0.0785135158631732 no 339 0.101365690655653 601 1714895 YML126C ERG13 SGTC_522 1273-0010 11.6 µM 1.27298208675124 0.0786427511489551 no 340 0.101512199236708 545 5705015 SGTC_2131 toluylene red 5.2905 µM 1.27161006163294 0.0788577312443942 no 341 0.101755850019253 557 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1531 st059297 52.4 µM 1.26743264481631 0.0795150245650947 no 342 0.102500316647285 589 7566702 SGTC_2065 5221596 34.26 µM 1.26706461460599 0.0795731301992277 no 343 0.102566093431561 568 788581 SGTC_1080 nisoldipine 24.4 µM 1.26664518891721 0.0796393894595971 no 344 0.102641093360647 604 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.26453748631809 0.0799729882959159 no 345 0.103018587362317 630 6708784 An antioxidant flavonoid SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.26060315326916 0.0805985243504235 no 346 0.103725930999952 676 368090 SGTC_2172 5754775 163.918 µM 1.26013478924923 0.0806732369845128 no 347 0.103810371092099 535 2263357 SGTC_468 gf-109203x 121 µM 1.25993525288977 0.0807050825693695 no 348 0.103846360109268 413 2396 A protein kinase C inhibitor. SGTC_1610 st001799 48.1 µM 1.25875140831121 0.0808942169543251 no 349 0.104060068243964 504 621897 SGTC_1153 4055-0057 267 µM 1.25820117141641 0.0809822381909567 no 350 0.104159505722615 598 882706 SGTC_1554 st069299 38.7 µM 1.25654878891135 0.0812470038648583 no 351 0.104458534280572 582 24207999 SGTC_710 3448-4187 58 µM 1.2564358379041 0.0812651261262546 no 352 0.104478997501236 678 3946412 SGTC_3132 9126706 49.47 µM 1.25320422253869 0.0817849106716572 no 353 0.105065696827173 545 850858 SGTC_3307 9126885 69.2785 µM 1.24061891505924 0.0838330751141802 no 354 0.107373280524063 610 24824909 SGTC_700 3453-2283 142 µM 1.23794415046629 0.0842732948692528 no 355 0.107868385058335 654 565664 SGTC_736 0958-0254 92.6 µM 1.23662898972869 0.0844903826679656 no 356 0.108112426156899 641 6812352 SGTC_2880 9042983 58.44 µM 1.23658616109324 0.0844974592494642 no 357 0.108120380111591 605 6464714 SGTC_537 1334-0398 209 µM 1.23241115998859 0.0851894316261394 no 358 0.108897767097533 613 5846986 SGTC_2874 9043904 71.43 µM 1.23101779820834 0.0854213124662396 no 359 0.109158103820828 489 4463428 SGTC_1984 st072354 53.1 µM 1.23078586804053 0.0854599557317742 no 360 0.109201481201914 596 5762938 SGTC_3117 9124945 49.47 µM 1.23027004638201 0.0855459467865778 no 361 0.109297998575419 503 17592065 SGTC_3322 9139058 2.11 µM 1.23008670693386 0.0855765263491714 no 362 0.109332318682368 606 4908926 YPR165W RHO1 SGTC_2363 9053361 176 µM 1.22965600219001 0.0856483966766885 no 363 0.109412974626338 619 6469797 YMR079W SEC14 SGTC_788 1182-0090 188 µM 1.2261201962533 0.0862401144899262 no 364 0.110076723369665 726 5715185 SGTC_2160 5660466 132.927 µM 1.22596015438463 0.0862669696775871 no 365 0.11010683494534 585 2859134 SGTC_2264 7948757 110.76 µM 1.22315111518109 0.0867393481294168 no 366 0.110636312705783 574 2971411 SGTC_2969 9091408 28.7 µM 1.2209367428358 0.0871130856170537 no 367 0.11105498569595 578 4286311 SGTC_784 4579-0127 173 µM 1.22089964664175 0.087119356867087 no 368 0.111062009150695 635 1948547 SGTC_1497 4476-2978 41.3 µM 1.21803785333405 0.0876041705949272 no 369 0.111604794184241 656 1528379 SGTC_2643 anethole 100 µM 1.2178677810408 0.0876330456303042 no 370 0.111637110768274 633 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_585 0kpi-0023 191 µM 1.21653789572553 0.0878590797320971 no 371 0.111890042120232 567 64601 SGTC_2871 9038510 12.99 µM 1.21644640868329 0.0878746453082016 no 372 0.11190745712602 653 4945164 SGTC_1013 4112-3890 241 µM 1.21623890917091 0.0879099568312335 no 373 0.111946962856048 630 705171 SGTC_1921 5740136 50 µM 1.21413425233505 0.0882687179868567 no 374 0.112348231063899 671 1774243 SGTC_444 curcumin 90.4 µM 1.21235170813472 0.0885734241537001 no 375 0.112688889122518 645 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_771 0250-0039 27.3 µM 1.21138098508086 0.0887396876802265 no 376 0.112874711763247 611 3005115 SGTC_829 1635-0120 117 µM 1.20993243046566 0.0889882252778674 no 377 0.113152410875253 642 285054 SGTC_1842 st055362 61.2 µM 1.20805181238928 0.0893116672644888 no 378 0.113513666686507 662 676032 SGTC_810 3825-7150 143 µM 1.20769192137383 0.0893736634400232 no 379 0.113582893308301 648 22330411 YGL099W LSG1 SGTC_1429 4049-0205 9.46 µM 1.20125243492281 0.0904883705111289 no 380 0.11482664755627 657 22774478 SGTC_2459 5811157 9.22 µM 1.19819564972733 0.0910211140283432 no 381 0.11542042929104 596 2870684 YBR192W RIM2 SGTC_1704 st028805 70.8 µM 1.19817029522775 0.0910255425762691 no 382 0.115425363520199 600 2876101 SGTC_558 k064-0027 21.3 µM 1.19809035600775 0.0910395062198528 no 383 0.115440921441606 621 5088526 SGTC_1442 4112-3290 3 µM 1.19791341840257 0.0910704190224997 no 384 0.115475362670594 648 704353 SGTC_624 k048-0052 28 µM 1.19747264848586 0.0911474598701197 no 385 0.115561191089781 602 6835531 SGTC_2656 pseudo-anisatin 100 µM 1.19352772840912 0.0918391337194524 no 386 0.116331379650193 598 6708809 A neurotoxin. SGTC_939 1165-0479 45.3 µM 1.18972170297851 0.0925101323013609 no 387 0.117077896149012 631 1377347 SGTC_1091 telmisartan 47.6 µM 1.18960819805544 0.0925301986579152 no 388 0.117100211087261 629 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2256 7954252 200 µM 1.18888883556591 0.0926574484984473 no 389 0.117241707002195 529 2972920 SGTC_1252 0493-0875 34.8 µM 1.18700154871841 0.0929919105896008 no 390 0.117613504811942 610 3960963 SGTC_3274 9138298 49.47 µM 1.18362091470738 0.0935932510402374 no 391 0.118281578747736 659 17015756 SGTC_904 1141-0088 396 µM 1.18136209061894 0.0939966434330418 no 392 0.118729455512777 610 1378119 SGTC_3053 9095903 49.47 µM 1.18065418929954 0.0941233277481164 no 393 0.118870063539429 622 17174018 SGTC_841 0251-0215 91.2 µM 1.17802721824283 0.0945945452419558 no 394 0.119392877718819 699 3888614 SGTC_751 0833-0568 350 µM 1.17586493091096 0.0949837122599268 no 395 0.119824427296878 640 6954252 SGTC_3143 9086658 49.47 µM 1.17301778638035 0.095497936629865 no 396 0.120394336579225 716 25236626 SGTC_1815 st051655 58.2 µM 1.17256980420141 0.0955790331488756 no 397 0.120484182146677 608 5984156 SGTC_1786 berberine 21.6 µM 1.17073567155479 0.0959115877613908 no 398 0.120852521042356 639 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3089 9117425 49.47 µM 1.17054878929787 0.0959455199136892 no 399 0.120890096030793 587 9401657 SGTC_2394 5221648 200 µM 1.16950453624905 0.0961352871138823 no 400 0.121100207335088 726 788586 SGTC_1403 3909-7815 62.9 µM 1.16635928972878 0.09670852497549 no 401 0.121734605445047 597 6615483 SGTC_695 3505-6186 243 µM 1.16270691673619 0.0973773348550071 no 402 0.122474217176125 666 1819379 SGTC_1731 st035964 63 µM 1.16201369935495 0.0975046566198764 no 403 0.12261495015983 626 6739575 SGTC_1043 0916-0009 19.3 µM 1.16049747145778 0.097783564477215 no 404 0.122923161314662 759 3101130 SGTC_182 3448-4371 550.524 µM 1.15943301763135 0.0979797182894747 no 405 0.123139862397698 692 3491403 SGTC_3068 9116768 49.47 µM 1.1581995200411 0.0982073833884318 no 406 0.123391312079825 591 41904888 SGTC_55 0767-0285 6.563 µM 1.15684887582435 0.098457114284578 no 407 0.123667054539626 696 3116166 SGTC_1747 st037496 66.6 µM 1.15331364421798 0.099112970880547 no 408 0.124390835913113 685 723305 SGTC_3187 9109394 49.47 µM 1.15171733919192 0.0994101624864443 no 409 0.12471862238668 664 17098090 SGTC_648 0375-0473 33.3 µM 1.15115283566436 0.0995154145158082 no 410 0.124834682319904 696 1713139 SGTC_2831 7999036 19.48 µM 1.14975237917815 0.0997768820988379 no 411 0.125122937006069 694 2988270 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.14638340495422 0.100407930286473 no 412 0.125818273065354 649 5355888 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.14553705869536 0.100566917555013 no 413 0.125993376633173 711 676296 Flavone; oxidizing agent. SGTC_3147 9097027 49.47 µM 1.14221946090322 0.101191903607233 no 414 0.126681404344399 707 25236841 SGTC_1277 0873-0036 22 µM 1.14220845185817 0.101193982248548 no 415 0.126683691827928 714 5965735 SGTC_2857 9024691 58.44 µM 1.14220189284891 0.101195220683892 no 416 0.126685054686934 613 16478292 SGTC_99 0109-0120 622.8 µM 1.14130315693651 0.101365019413261 no 417 0.126871894436863 614 759414 SGTC_1178 0988-0033 191 µM 1.14060267731358 0.101497505316556 no 418 0.127017651308296 693 5392207 SGTC_1559 coumarin 343 70.1 µM 1.14009165362253 0.101594237819558 no 419 0.127124059396654 628 108770 A hepatotoxic, DNA x-linker. SGTC_2072 5231554 129 µM 1.13871922066046 0.10185436010174 no 420 0.127410141671471 683 789545 SGTC_1225 1216-0074 20.6 µM 1.13785941752749 0.102017568550394 no 421 0.127589594725596 675 4241466 SGTC_2770 toltrazuril 17.5 µM 1.13534363581743 0.102496208898651 no 422 0.128115682926967 709 68591 Kills coccidiodes. SGTC_2823 7987624 58.44 µM 1.13513035421347 0.102536861766045 no 423 0.12816035253349 694 2239440 SGTC_1394 3474-0001 65.7 µM 1.13182416752256 0.103168542436 no 424 0.128854182546972 592 5017666 YIL048W NEO1 SGTC_1901 st060216 58.6 µM 1.12933099992888 0.103646753144297 no 425 0.129379114168502 688 688792 SGTC_2523 spermine 47.74 µM 1.12931588214435 0.103649657761281 no 426 0.129382301702523 667 1103 A DNA binding polyamine. SGTC_900 1112-0045 141 µM 1.12816003498975 0.103871908421801 no 427 0.129626169341229 539 56211 YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM 1.12380427652609 0.104712555547444 no 428 0.13054803343077 640 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2940 9060638 45.86 µM 1.12242879560085 0.104979039740052 no 429 0.130840083373202 679 4027022 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.11630239301959 0.106171925607673 no 430 0.132146358821682 727 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_611 3453-1652 23.7 µM 1.11615236240017 0.106201260742591 no 431 0.13217846084598 722 1560575 SGTC_365 0121-0052 13.6 µM 1.11455734262813 0.106513493255204 no 432 0.132520079367569 753 3101739 SGTC_47 0149-0135 24.25 µM 1.11297586635151 0.106823728329619 no 433 0.132859397295808 652 5239155 SGTC_271 rotenone 740 µM 1.11131807242011 0.107149633873028 no 434 0.133215731509758 712 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_638 3970-0837 4.09 µM 1.1096589447721 0.10747651888584 no 435 0.133573010284845 703 4118451 YLR208W SEC13 SGTC_2117 5521686 200 µM 1.10829968837189 0.107744857730913 no 436 0.133866205012229 688 803312 SGTC_2142 5622915 118.518 µM 1.10186903396877 0.109020914598789 no 437 0.135259306338553 668 5322196 SGTC_512 prima-1 270 µM 1.10158354961018 0.109077814994537 no 438 0.13532138164686 726 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2953 9074162 66.49 µM 1.09797584313907 0.109798713112566 no 439 0.136107518910611 649 16451992 SGTC_1881 5652484 16 µM 1.09562874916214 0.110269545838389 no 440 0.136620637563863 677 2255129 SGTC_3281 9140613 49.47 µM 1.09517264836223 0.110361208540188 no 441 0.136720503031901 648 16013766 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.09338093571857 0.110721818378219 no 442 0.137113290185 714 5377381 SGTC_3272 9137413 49.47 µM 1.09008265155808 0.11138785530292 no 443 0.137838368783001 684 17614870 SGTC_2723 salbutamol 83.58 µM 1.08650299759342 0.112113950095268 no 444 0.138628257717261 612 9884233 β2-adrenoceptor agonist SGTC_3094 9117742 49.47 µM 1.07981773322133 0.113479031809942 no 445 0.140111676419063 761 17149698 SGTC_359 0081-0058 15.9 µM 1.07230169151525 0.115027857893333 no 446 0.141792273636276 670 3494159 SGTC_334 1502-1024 68.5 µM 1.0657954037007 0.116380694658503 no 447 0.143258069557106 755 3296216 SGTC_2896 9052656 71.43 µM 1.0654517203259 0.116452468472817 no 448 0.14333578123113 811 6469436 SGTC_2145 5634607 200 µM 1.06532378637671 0.116479193836037 no 449 0.14336471617639 667 308662 SGTC_891 0929-0073 133 µM 1.05913471613133 0.11777728829359 no 450 0.144769215734916 750 5603632 SGTC_916 4466-0038 42 nM 1.05888971693722 0.117828884193198 no 451 0.144825003966906 877 5722064 YGL116W CDC20 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.05741080958658 0.118140676135108 no 452 0.145162070151789 816 5024745 SGTC_760 0568-0725 82.9 µM 1.05682299225551 0.11826476514227 no 453 0.145296189442828 794 3916171 SGTC_3079 9117512 49.47 µM 1.0557318456516 0.118495351856919 no 454 0.145545371761533 813 7185044 SGTC_2247 cerulenin 830 nM 1.05321594821666 0.119028234720123 no 455 0.146121015378413 749 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_407 eburnamonine 100 µM 1.04842793269151 0.120047035766266 no 456 0.147220744857314 687 3195 SGTC_474 dl-dihydrosphingosine 5 µM 1.04332797767114 0.12113895457662 no 457 0.148398208818352 748 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2031 5180455 200 µM 1.04215627984158 0.121390803131722 no 458 0.148669614589228 715 29949 SGTC_1646 st011709 75.6 µM 1.04135753637351 0.121562698536518 no 459 0.148854821302298 713 5757843 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.03738944303937 0.122419197122713 no 460 0.149777198164005 773 94937 An inhibitor of serotonin biosynthesis. SGTC_1190 1486-1332 13 µM 1.03453281935852 0.123038405024595 no 461 0.150443571071016 770 4150046 SGTC_3027 9089541 49.47 µM 1.03377845711973 0.123202288023804 no 462 0.150619872501241 751 9943819 SGTC_896 0964-0007 44.5 µM 1.03354962975929 0.12325203032722 no 463 0.150673378759523 783 6756758 SGTC_2268 7933382 153.85 µM 1.03296077396294 0.123380100015176 no 464 0.150811127959115 835 935025 YOR257W CDC31 SGTC_2068 5226020 147 µM 1.03138859984093 0.123722487313506 no 465 0.151179312363997 796 1810509 SGTC_616 4092-0450 108 µM 1.03104200865188 0.123798057176341 no 466 0.151260560259643 811 787165 SGTC_1121 fusaric acid 630.51 nM 1.03044760701272 0.123927734215989 no 467 0.151399967479498 773 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1194 1488-0194 225 µM 1.0262513183155 0.124845918137093 no 468 0.152386568743939 803 1391452 SGTC_556 4058-0063 51.5 µM 1.02597991488892 0.124905466759479 no 469 0.152450525758521 829 6615692 SGTC_2703 st077852 53.4 µM 1.02550064500299 0.125010671814448 no 470 0.152563510613302 741 6281836 SGTC_91 0417-1751 58.384 µM 1.02389893475644 0.125362713995251 no 471 0.152941506715493 888 6795624 SGTC_1164 k060-0068 93.7 µM 1.02326433889351 0.125502383956649 no 472 0.153091439957828 812 5963676 SGTC_3092 9117248 49.47 µM 1.0225681852141 0.125655727218145 no 473 0.153256029222902 843 17141857 SGTC_1848 st056003 16.4 µM 1.02127122457472 0.125941760034282 no 474 0.153562977840657 813 146492 SGTC_1078 idebenone 36.1 µM 1.01715673743158 0.126852176253836 no 475 0.15453943648537 818 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1735 st034310 56.75 µM 1.01679890925932 0.126931569219925 no 476 0.154624550561245 774 871153 SGTC_1855 st056195 39.6 µM 1.01468743071723 0.127400756780996 no 477 0.155127423781398 758 4028379 SGTC_2748 diazoxide 86.69 µM 1.01256492619508 0.127873608683066 no 478 0.155634009986012 727 3019 A potassium channel activatior. SGTC_793 0488-0545 106 µM 1.01139542911972 0.128134669901959 no 479 0.1559136040035 786 292548 SGTC_305 1682-2595 20.8 µM 1.00750676511386 0.129005378504739 no 480 0.156845654183488 819 226033 SGTC_565 1418-0001 44.5 µM 1.00675156608192 0.129174949364521 no 481 0.157027087506884 841 2862145 SGTC_1979 st071809 45.3 µM 1.00545462960945 0.129466521260648 no 482 0.157338992910614 821 4976333 SGTC_1733 st037357 54.9 µM 1.00296935536946 0.130026523733425 no 483 0.157937823596353 779 1272339 YGL099W LSG1 SGTC_54 0159-0055 9 µM 1.00219167667282 0.130202100598825 no 484 0.15812551348529 803 3319099 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.00001554581409 0.130694278154624 no 485 0.158651492328798 717 6857784 SGTC_2433 5607874 27.82 µM 0.999266447387347 0.130863999645014 no 486 0.158832817290763 778 2252428 SGTC_1070 indatraline 8.81 µM 0.99512599323892 0.131804840079913 no 487 0.159837494988594 798 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1651 st011928 86.1 µM 0.994926101330745 0.131850379548203 no 488 0.159886103556547 800 720198 SGTC_2123 5259487 200 µM 0.99197940300527 0.13252295726115 no 489 0.160603786499237 847 2173474 SGTC_2777 climbazole 1.536 µM 0.991852482320195 0.132551979647005 no 490 0.160634745854155 837 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2546 rhodinyl acetate 100 µM 0.991562233976715 0.132618365895016 no 491 0.160705559848257 845 6708682 SGTC_610 4215-0184 155 µM 0.990480061202676 0.132866084741043 no 492 0.16096976506448 847 5605015 SGTC_1270 0831-1170 17.3 µM 0.989169096832192 0.133166602522906 no 493 0.161290207747029 879 6764716 SGTC_999 SEC7.066 22.7 µM 0.98875648707436 0.133261283469548 no 494 0.161391149133325 874 740511 YDR170C SEC7 SGTC_1605 st000082 49.1 µM 0.987530277191318 0.133542933348948 no 495 0.161691373801617 827 1114022 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.986175325326402 0.133854629948042 no 496 0.162023542659519 830 23665772 A membrane-active detergent. SGTC_1682 st012968 530 nM 0.983651673515114 0.134436509405687 no 497 0.162643404379683 725 24207270 SGTC_1822 st052468 42 µM 0.980579259975291 0.13514725819265 no 498 0.163400133047939 791 2873678 SGTC_154 3389-1638 511.116 µM 0.980196676798011 0.135235942135495 no 499 0.163494522305424 728 5238686 SGTC_2947 9072639 7.68 µM 0.978243955670782 0.135689210251865 no 500 0.163976840656327 890 16488146 SGTC_1116 jasmonic acid  1.58368 µM 0.975472678308082 0.136334267308539 no 501 0.164662923923499 836 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_501 nsc-95397 161 µM 0.974423236455693 0.136579087699251 no 502 0.164923218359747 809 262093 SGTC_3213 9129884 49.47 µM 0.97351978394662 0.136790091460735 no 503 0.165147516187983 739 17190742 SGTC_2036 5160441 105 µM 0.970927113916439 0.137396853376404 no 504 0.165792287537769 885 134534 YIL048W NEO1 SGTC_1423 4048-0112 5.59 µM 0.968422699713246 0.137984703334221 no 505 0.166416653624555 857 X1423 SGTC_1645 Cervolide 78 µM 0.966944614947937 0.138332451436088 no 506 0.166785860853292 796 23173 A fragrance. SGTC_1902 st060212 70.5 µM 0.964888652922825 0.13881714897233 no 507 0.167300292729766 853 688944 SGTC_2689 tacrolimus 100 µM 0.961407371174109 0.139640503260306 no 508 0.168173689730696 800 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2328 6201408 200 µM 0.961201239494609 0.139689359162171 no 509 0.168225496647448 799 2890418 SGTC_2000 st075254 36.4 µM 0.961116129833113 0.139709534653702 no 510 0.168246890187687 818 17234175 SGTC_566 0958-0068 16.5 µM 0.961075988151503 0.139719051043009 no 511 0.168256980985346 776 6815365 SGTC_1055 3448-0672 86 µM 0.957221224263631 0.1406349535355 no 512 0.169227803270156 810 748378 SGTC_681 1642-0006 26.6 µM 0.956948233707443 0.140699971000373 no 513 0.169296692033562 835 4446530 SGTC_139 0099-0334 718.624 µM 0.95605978575062 0.140911711590757 no 514 0.169521015167674 984 97690 SGTC_2695 st077686 51.995 µM 0.955944619024622 0.140939174678107 no 515 0.169550107429755 801 2876092 SGTC_1128 3448-9350 235 µM 0.950544217044545 0.142231052355655 no 516 0.170917898781777 755 619386 SGTC_2300 7976697 71.57 µM 0.949445589681248 0.142494842447152 no 517 0.171197016363165 754 2236109 SGTC_955 1216-0110 33 µM 0.945134532498081 0.143533160557617 no 518 0.172295098688208 842 3619719 SGTC_826 1683-5028 118 µM 0.945104237987589 0.143540475014891 no 519 0.172302830959633 846 722377 SGTC_593 1203-0218 61.7 µM 0.944819293678497 0.143609285698999 no 520 0.172375570043981 904 3666956 SGTC_1262 0737-0114 49.6 µM 0.943524933737381 0.143922138563882 no 521 0.172706233982141 921 765919 SGTC_2318 6029776 164 µM 0.942549057149446 0.1441583162556 no 522 0.172955803675091 849 818325 SGTC_1756 st041558 35.5 µM 0.941538756638776 0.14440310023868 no 523 0.173214418864488 949 3955792 SGTC_2846 9008642 19.48 µM 0.939649165579601 0.144861677521148 no 524 0.173698774133165 795 2992898 SGTC_2998 9066762 71.4286 µM 0.938424924744196 0.14515930651709 no 525 0.17401304095558 878 4945196 SGTC_604 1000-0114 314 µM 0.934923085673718 0.146012920217255 no 526 0.17491396942685 930 1572745 SGTC_2021 4019055 173 µM 0.934458651364503 0.146126384231513 no 527 0.17503367774257 950 44827708 YER133W GLC7 SGTC_1042 0350-0096 82 µM 0.932820238267573 0.146527131026035 no 528 0.175456395017386 845 3122515 SGTC_2768 sulfasalazine 50.2 µM 0.932778931129969 0.146537244048191 no 529 0.175467060784127 889 5384001 An antioxidant and salicylic acid derivative. SGTC_712 r015-0009 80.6 µM 0.931938467968608 0.146743112226047 no 530 0.175684162984709 828 6813872 YLR060W FRS1 SGTC_1024 4507-0395 26 µM 0.927745334583123 0.14777310199381 no 531 0.176769843144609 834 4201836 SGTC_211 3455-0679 143.504 µM 0.927509088443303 0.147831276553544 no 532 0.176831137611222 898 748649 SGTC_118 0083-0097 135.343 µM 0.924109856192221 0.148670019900622 no 533 0.177714561097544 1052 5207356 SGTC_1839 st053978 48 µM 0.924093326846872 0.148674106189483 no 534 0.177718863686388 882 3788398 SGTC_868 0527-0199 213 µM 0.921617276568243 0.149287069004888 no 535 0.178364121801329 891 2849450 SGTC_2472 5377652 49.4 µM 0.921593815842748 0.149292884922538 no 536 0.178370242711724 879 1610903 SGTC_496 calpeptin 138 µM 0.921491152056739 0.149318337071151 no 537 0.17839702928132 799 73364 A calpain inhibitor. SGTC_1762 st045503 25.4615 µM 0.920349035553552 0.149601683114849 no 538 0.178695196048316 893 4645554 SGTC_489 paxilline 115 µM 0.918999718365648 0.149936895313392 no 539 0.179047859755512 838 105008 A toxic potassium channel blocker. SGTC_1229 0139-0193 12.2 µM 0.918945392496153 0.149950402023697 no 540 0.179062067777295 933 3090752 SGTC_3061 glucosamine 200 µM 0.914397024347887 0.151084112993702 no 541 0.180254132419069 884 91431 and experimental redox chemotherapeutic SGTC_2186 6124449 200 µM 0.911526086284115 0.151802642026806 no 542 0.181009123635798 890 3834182 YLR033W RSC58 SGTC_776 4476-4378 112 µM 0.908850446039464 0.152474333487376 no 543 0.181714537061364 860 2892008 SGTC_1707 st032323 6.317 µM 0.907890765590397 0.152715731056688 no 544 0.181967968479067 885 3132057 YMR211W DML1 SGTC_1841 st054148 70 µM 0.907546188226295 0.152802467702568 no 545 0.182059018012671 836 675442 SGTC_329 k048-0121 21.3 µM 0.905230836412273 0.15338613276723 no 546 0.182671554361555 879 6832902 SGTC_1127 asiatic acid 681.4 nM 0.905115323149252 0.153415290536222 no 547 0.182702147558716 846 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_801 0866-0028 10.1 µM 0.904355759241794 0.15360711051444 no 548 0.18290339450155 923 6849771 SGTC_2919 7978188 46.38 µM 0.9039378057663 0.153712728032103 no 549 0.183014190525306 923 2980291 SGTC_1709 st033179 39.1045 µM 0.903019253390072 0.153945016598664 no 550 0.183257838305915 914 573381 SGTC_936 3005-4620 401 µM 0.90247372302619 0.154083083198816 no 551 0.183402636979519 956 777207 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.902200971539365 0.15415214374031 no 552 0.183475059419656 986 91467 include heat shock SGTC_2742 clothiapine 36.27 µM 0.900843390844834 0.154496187029096 no 553 0.183835796658963 862 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1204 4049-0315 18.3 µM 0.900534257834247 0.154574599591301 no 554 0.183918001395799 879 588402 SGTC_3014 9081533 49.47 µM 0.896213750695703 0.1556732622261 no 555 0.185069306508529 922 21367265 SGTC_1640 st009078 66.4 µM 0.891331892809585 0.156920853172099 no 556 0.186375571874856 874 690618 SGTC_741 4582-0002 126 µM 0.889615064619852 0.15736115907052 no 557 0.186836307190222 899 2912688 SGTC_3174 9107204 49.47 µM 0.889393853895751 0.157417950826414 no 558 0.186895723462017 902 3938802 SGTC_432 NS 1619 61.3 µM 0.888005118674077 0.157774790589455 no 559 0.187268998964993 855 4552 A K+/calcium channel activator. SGTC_571 k831-0106 44.2 µM 0.879155208405196 0.160061273385857 no 560 0.189658563432905 888 4783639 SGTC_1971 st069429 63.5 µM 0.879029534863085 0.160093897936752 no 561 0.189692631053031 966 1246522 YGL099W LSG1 SGTC_580 1123-0028 41 µM 0.877078826113059 0.160600854721524 no 562 0.190221912277377 1066 1677248 YPR107C YTH1 SGTC_1322 1348-1070 12 µM 0.876713213458938 0.160695987928468 no 563 0.19032121396853 940 6758089 SGTC_3286 9117135 37.221 µM 0.874229643669413 0.16134319203493 no 564 0.190996602772609 901 3438150 SGTC_233 rapamycin 362 pM 0.873781744388774 0.161460092727385 no 565 0.191118562010757 1007 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1608 st001473 40.5 µM 0.872305009427653 0.161845908320522 no 566 0.191521002767808 898 7292267 SGTC_1679 SEC14.276 6.7 µM 0.871161519220318 0.162145071843832 no 567 0.191832983821716 1004 1005053 YMR079W SEC14 SGTC_749 1000-0129 128 µM 0.870594585891892 0.162293528172205 no 568 0.191987776843714 1005 708470 SGTC_930 2810-3379 265 µM 0.870209757218298 0.162394349243417 no 569 0.192092892341735 1011 1015764 SGTC_731 3966-0296 387 µM 0.86870974325216 0.16278772619084 no 570 0.192502955426475 937 660956 SGTC_1880 MG-132 525 µM 0.868178976648427 0.162927067438692 no 571 0.192648180685047 903 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2171 5739187 198.077 µM 0.866598436555179 0.163342463068641 no 572 0.193081035233444 924 2262761 SGTC_313 3474-0040 5.03 µM 0.865391555958283 0.163660116813502 no 573 0.193411957027436 940 1043375 YIL048W NEO1 SGTC_2361 9034121 116 µM 0.864217563195067 0.16396949895359 no 574 0.193734192907885 935 6496917 SGTC_2298 7976326 193.81 µM 0.863600071845318 0.164132378543763 no 575 0.193903812341226 882 2235818 SGTC_1214 0358-0031 63.7 µM 0.862598021584192 0.164396918915291 no 576 0.194179259253773 916 4301366 SGTC_2316 5844804 197.44 µM 0.862158026080945 0.164513164615814 no 577 0.194300281943171 1081 776813 SGTC_311 1315-0136 58 µM 0.861266818856026 0.164748782506473 no 578 0.194545553081298 957 6759207 SGTC_2233 sulbentine 40.3845 µM 0.860533963860652 0.164942698854666 no 579 0.194747384861242 985 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_102 gallobenzophenone 83.616 µM 0.858009337939694 0.16561185603967 no 580 0.195443653591778 949 70837 SGTC_1513 0337-0559 19 µM 0.857781242565121 0.165672399531397 no 581 0.195506634595501 885 775073 SGTC_1179 1021-1431 9.29 µM 0.857245006231512 0.16581478942723 no 582 0.195654747087952 976 2840958 SGTC_431 k089-0097 107 µM 0.855418575698778 0.166300365364286 no 583 0.196159731809337 984 5499420 SGTC_293 4049-0273 38.5 µM 0.854517650731183 0.166540223694503 no 584 0.196409116886803 912 1380311 SGTC_2986 9022445 71.43 µM 0.8535627705112 0.166794690482956 no 585 0.196673646981487 975 6459286 SGTC_770 0389-1121 67.2 µM 0.852422143119185 0.167098985794394 no 586 0.196989917247491 1020 6753108 SGTC_1687 st020778 55.3625 µM 0.852260322443722 0.167142185109641 no 587 0.197034811395774 1033 4259299 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.851168497680014 0.167433844566885 no 588 0.197337879760323 926 6708760 SGTC_3182 9108849 49.47 µM 0.849102283865417 0.167986689770382 no 589 0.197912189842056 1019 17133045 SGTC_769 0302-0231 76 µM 0.847459035152612 0.168427202345394 no 590 0.198369655528877 1033 571869 YER009W NTF2 SGTC_2957 9076800 11.52 µM 0.84460838651209 0.169193148011563 no 591 0.199164762524397 901 16459615 SGTC_1355 1499-0035 1.68 µM 0.841349631132341 0.170071483692596 no 592 0.200076047031242 964 1548538 SGTC_349 k015-0014 24 µM 0.840824799610903 0.170213214816224 no 593 0.200223045902914 914 2196908 SGTC_1409 3909-8004 61.9 µM 0.839649345731426 0.170530921434154 no 594 0.20055251149146 997 2119279 SGTC_3 0833-0587 95.581 µM 0.839480468389143 0.170576597487789 no 595 0.200599872510914 967 5382644 SGTC_2165 5727197 32.143 µM 0.838915336488973 0.170729504997932 no 596 0.200758410470716 937 1361712 SGTC_2915 7971052 15.16 µM 0.836942748625776 0.171263914594339 no 597 0.201312374898067 848 5741558 SGTC_2800 7887935 81.82 µM 0.836126104500755 0.171485470902577 no 598 0.201541982080772 941 2961002 SGTC_1318 1280-3875 124 µM 0.834483441519025 0.171931681389361 no 599 0.20200430720431 986 373245 SGTC_1161 k007-0610 110 µM 0.832398118934665 0.172499202124764 no 600 0.202592131733358 1066 5843850 SGTC_3150 9097574 49.47 µM 0.832071726813094 0.172588137779384 no 601 0.202684229755458 989 17217476 SGTC_1751 st044839 27.194 µM 0.831944176819875 0.172622900674031 no 602 0.202720227318471 1009 5291326 SGTC_1377 2944-0135 198 µM 0.830151448608513 0.173111968981384 no 603 0.203226580833068 1018 1894137 SGTC_2788 5282734 71.43 µM 0.829548189464728 0.173276740397569 no 604 0.203397140120461 1028 743706 SGTC_557 1315-0110 16.2 µM 0.82840074724951 0.173590422974826 no 605 0.203721791750093 1048 6833801 SGTC_928 2764-0428 58.7 µM 0.827353971688133 0.173876900730877 no 606 0.204018230557974 1018 662578 SGTC_280 3448-3607 3.04 µM 0.82580773184326 0.174300619801727 no 607 0.204456583697033 1008 626179 SGTC_2497 7-hydroxyflavone 100 µM 0.82489320641289 0.174551537467959 no 608 0.204716111810198 941 5281894 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.821882396680331 0.175379230864962 no 609 0.205571916295471 1027 688798 SGTC_673 1082-0474 110 µM 0.82171595060867 0.17542506056065 no 610 0.205619289458548 1101 3098046 SGTC_1172 0370-0043 85 µM 0.820298282094393 0.175815712766483 no 611 0.206023042741966 1012 376585 SGTC_1861 st057647 17.4 µM 0.818773105538815 0.176236604637521 no 612 0.206457938999727 1024 688668 SGTC_290 2043-6722 48.1 µM 0.818407597023832 0.17633756600324 no 613 0.206562242608264 1006 773758 YLR208W SEC13 SGTC_172 1112-0046 2.638 µM 0.817840283670346 0.176494342700425 no 614 0.206724196208223 910 2802135 YIL048W NEO1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.81752924335575 0.176580335908868 no 615 0.206813022244818 1013 6312947 SGTC_426 0988-0037 14.6 µM 0.817360431294543 0.176627018412143 no 616 0.206861240585831 1042 5383008 SGTC_866 0495-0101 262 µM 0.817026498247995 0.176719385690842 no 617 0.206956642572158 940 635694 SGTC_147 4466-0538 29.23 µM 0.816209671875694 0.176945451968751 no 618 0.207190113009583 1131 6742687 YHR072W ERG7 SGTC_266 formosanin C 406 nM 0.816178948809247 0.1769539585023 no 619 0.2071988975079 1019 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_13 0199-0087 65 µM 0.814087970116838 0.177533511201095 no 620 0.207797278484988 1064 4589825 SGTC_341 1486-1430 230 µM 0.81247521203427 0.177981333773438 no 621 0.208259502217783 1030 2054753 YPL210C SRP72 SGTC_1307 1187-1599 12.2 µM 0.810732804958713 0.178465956376548 no 622 0.208759565024166 1026 1538471 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.810528155419292 0.178522930865368 no 623 0.208818344898957 973 689007 SGTC_1108 betulinic acid 729.144 nM 0.810013958713417 0.178666133919666 no 624 0.208966076594201 1028 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2423 st077119 87.2 µM 0.810005819171041 0.178668401352083 no 625 0.208968415626779 1024 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_122 0236-0016 402.397 µM 0.80960678058451 0.178779583753484 no 626 0.209083104895838 1131 6808838 SGTC_231 b-estradiol 524 µM 0.809434531226342 0.178827590305051 no 627 0.209132623220879 970 450 A steroid. SGTC_3244 9134489 49.47 µM 0.809252371910827 0.178878367626548 no 628 0.20918499797686 1019 16584271 SGTC_1101 ebselen 5.29 µM 0.80815347482702 0.179184880140204 no 629 0.209501118500554 1103 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.805484915894647 0.179930588549951 no 630 0.210269953695915 1086 16486 A toxic proline analog. SGTC_2725 haloperidol 53.21 µM 0.804652384364895 0.180163631418976 no 631 0.210510151984734 1044 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2335 9018011 154.17 µM 0.803112392215454 0.18059520631333 no 632 0.210954887866733 1071 6458208 SGTC_2019 4016004 108 µM 0.80114270972325 0.181148143785859 no 633 0.211524516565222 1012 45595336 SGTC_2453 5731132 22.18 µM 0.799320931006049 0.181660504046121 no 634 0.21205217256397 1075 1362040 SGTC_481 bay k-8644 50 µM 0.796100482763581 0.182568444340037 no 635 0.212986816797789 992 2303 A calcium channel antagonist. SGTC_1614 st002383 48.6 µM 0.795705677766538 0.182679946318138 no 636 0.213101562979376 1068 1947235 SGTC_301 4119-0100 24.5 µM 0.791952901008878 0.183741938442288 no 637 0.214194069715884 1061 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1824 st053723 68.6 µM 0.789823090377779 0.184346357323415 no 638 0.214815546051704 1073 675225 SGTC_3054 9094397 49.47 µM 0.789541452963012 0.184426375699561 no 639 0.214897805882088 1096 2598354 SGTC_2112 5488546 200 µM 0.789302766969815 0.184494207698353 no 640 0.214967534908867 1053 600757 SGTC_934 2950-0684 338 µM 0.788411625789529 0.184747597556446 no 641 0.215227986361761 1084 1121253 SGTC_2121 5257820 149.641 µM 0.788088628136042 0.184839493107485 no 642 0.215322433225915 1113 791256 SGTC_194 1486-1323 56.904 µM 0.787145272136349 0.185108048448212 no 643 0.215598415034403 1078 5178754 SGTC_960 1222-0186 7.7 µM 0.786517602155924 0.185286868252188 no 644 0.215782155477203 1048 3126296 SGTC_1223 0764-0573 147 µM 0.785457577943955 0.185589106895172 no 645 0.216092666757871 1108 1609797 SGTC_3078 9116413 49.47 µM 0.785289626599713 0.185637021962232 no 646 0.216141888229259 1047 17177322 SGTC_6 0844-0013 19.835 µM 0.783873453188938 0.186041349164017 no 647 0.216557184042913 1211 1584900 SGTC_2566 crystal violet carbinol 226 nM 0.783135681869592 0.186252204050894 no 648 0.216773719793938 1002 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3339 9145883 14.936 µM 0.781593600866483 0.186693408480838 no 649 0.217226724401328 998 2030670 SGTC_1989 st071868 50.2 µM 0.781172835888412 0.186813905714976 no 650 0.217350423999117 1099 16414057 SGTC_1437 4092-1038 11.6 µM 0.780067360791127 0.187130717178684 no 651 0.217675613486907 1091 3977136 SGTC_1496 4469-0713 57.4 µM 0.779406803594938 0.18732018079979 no 652 0.217870058656031 1055 746691 SGTC_2766 oltipraz 83.91 µM 0.779171673031677 0.187387650486073 no 653 0.217939297120672 1031 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2089 5281248 129.67 µM 0.777828891091609 0.187773243671149 no 654 0.218334946695791 1045 2737878 SGTC_2404 5161160 200 µM 0.777521750937178 0.187861510839028 no 655 0.218425503396825 1069 2831543 SGTC_3072 9116419 49.47 µM 0.773989942269855 0.188878336596987 no 656 0.219468369512506 1064 17170162 SGTC_2765 myclobutanil 7.74 µM 0.77375249885358 0.188946819212076 no 657 0.219538583846679 1068 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3074 9116018 49.47 µM 0.773693072652452 0.188963961106071 no 658 0.219556158772512 1092 17027303 SGTC_2519 cryptotanshinone 88.04 µM 0.771910743890023 0.189478531213615 no 659 0.220083646764182 1071 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3105 9121040 49.47 µM 0.770011679370703 0.190027751537179 no 660 0.220646482318134 900 41448907 SGTC_2710 st078562 53.7235 µM 0.768488430946302 0.190468990113028 no 661 0.221098530629831 1092 17250908 SGTC_1425 4048-4433 7.33 µM 0.767454518493894 0.190768841115907 no 662 0.221405662358191 1148 23734946 SGTC_1854 st056233 32.9 µM 0.765780139570143 0.191255051544499 no 663 0.221903566682027 1037 5393174 SGTC_1587 estradiol valerate 56.1 µM 0.763942448930605 0.191789558343515 no 664 0.222450769755924 1094 13791 A steroid. SGTC_2817 7995342 71.43 µM 0.763475630408257 0.191925481728879 no 665 0.22258989524061 1064 18879975 SGTC_3052 9092717 49.47 µM 0.760230646195744 0.192871951255127 no 666 0.223558364696192 1094 25237534 SGTC_1800 st050079 29.0735 µM 0.759028152689739 0.193223407155967 no 667 0.223917858028771 1122 3645560 SGTC_2682 pyrogallin 40.03 µM 0.758335092977331 0.193426146972678 no 668 0.224125201918208 1156 822798 An ATP competetive kinase inhibitor. SGTC_2293 7624732 200 µM 0.756519269034386 0.193957942616477 no 669 0.224668961958811 1105 894453 SGTC_755 1995-0008 37.3 µM 0.754103658168047 0.194666775745634 no 670 0.225393490488668 1133 689533 SGTC_2854 9024559 71.43 µM 0.753191537368544 0.194934836473594 no 671 0.225667411980154 1097 3163529 SGTC_2451 5856223 45.7 µM 0.751987681039418 0.195288977994173 no 672 0.22602923354353 1088 2179896 SGTC_954 1189-0853 2.85 µM 0.751096240973069 0.195551466949742 no 673 0.226297368922929 1128 2828194 SGTC_3055 9094636 49.47 µM 0.750827152281835 0.195630743528172 no 674 0.226378343137311 1133 25236176 SGTC_2334 9017922 200 µM 0.750762104539687 0.195649910258406 no 675 0.226397919770574 1114 3163164 SGTC_1330 1469-0054 61.8 µM 0.747379350927283 0.196648230688602 no 676 0.22741730306997 1148 7102664 SGTC_834 0312-0008 75.7 µM 0.744901911042519 0.197381328146029 no 677 0.228165509887862 1131 6385573 YIL048W NEO1 SGTC_2025 5147754 141 µM 0.744372888674586 0.197538084659794 no 678 0.228325458045402 1124 315777 YLR208W SEC13 SGTC_511 blebbistatin 171 µM 0.743623989891448 0.197760122186134 no 679 0.228551992818313 1126 3476986 A myosin inhibitor. SGTC_3060 1327-0027 12.5 µM 0.743520638794525 0.197790776111355 no 680 0.228583265454533 1071 16000455 YPR107C YTH1 SGTC_1835 st008666 49.2 µM 0.743511038651609 0.197793623658523 no 681 0.22858617044919 1018 690455 SGTC_3237 9133362 49.47 µM 0.742428419262417 0.19811490377815 no 682 0.22891390309766 1082 43845137 SGTC_2893 9048488 25.97 µM 0.742400417238814 0.198123217888319 no 683 0.228922383421703 1100 6467338 SGTC_1775 st081588 35.1725 µM 0.742007702031457 0.198239841565391 no 684 0.22904133454936 1179 1426443 YGL099W LSG1 SGTC_3203 9113543 49.47 µM 0.740587555758216 0.198661924686714 no 685 0.229471777801312 1102 17018012 SGTC_2047 4141938 200 µM 0.735477542158569 0.200185154658135 no 686 0.231024356174298 1091 3807862 SGTC_2161 5662504 8.5105 µM 0.735027240319239 0.200319719590264 no 687 0.231161452191452 1086 2859334 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.734785260396498 0.200392053556707 no 688 0.231235142598319 1160 688664 SGTC_549 1661-1316 519 µM 0.734674120061474 0.200425281493019 no 689 0.231268992675857 1165 2857282 SGTC_1656 st012921 11 µM 0.733822739558293 0.200679930860855 no 690 0.231528389811077 1054 6732821 SGTC_1568 digitonin 820 nM 0.73280251224717 0.200985338291941 no 691 0.231839444417023 1153 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2664 lyso-paf C-16 73.48 µM 0.731777983153121 0.201292313896116 no 692 0.232152044695441 1158 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2371 9071574 200 µM 0.730833534823232 0.201575544048226 no 693 0.232440418730996 1123 45596039 SGTC_742 0kpi-0133 140 µM 0.729196991927365 0.202066891040381 no 694 0.232940585498513 1156 2728852 SGTC_1660 st012960 28.1 µM 0.727740116915989 0.202504897944937 no 695 0.233386343953915 1119 24207266 SGTC_1690 st023502 41.2 µM 0.727073541471095 0.202705491798053 no 696 0.233590453009938 1117 24207482 SGTC_35 0133-0054 64.071 µM 0.726238837070641 0.202956848394968 no 697 0.23384618359677 1118 99677 SGTC_1268 0828-0275 2.46 µM 0.725671580234338 0.20312777403467 no 698 0.234020064074435 1180 745337 SGTC_1344 1488-0097 29.1 µM 0.725567000873527 0.20315929523217 no 699 0.234052128462427 1126 747966 SGTC_539 4859-0462 2.54 µM 0.725481858597575 0.203184960066708 no 700 0.234078235170863 1162 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_26 0302-0163 425.158 µM 0.725149629850395 0.20328512384013 no 701 0.234180120069299 1177 3100915 SGTC_1097 itavastatin 7.23 µM 0.724887628933609 0.203364135376473 no 702 0.234260485447327 1186 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2489 cantharidin 73.42 µM 0.724438799489941 0.203499531308795 no 703 0.234398193520561 1169 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1005 4092-0690 4.4 µM 0.723404279286394 0.203811814110557 no 704 0.234715771462537 1125 1529343 SGTC_145 3737-0113 38.366 µM 0.722322244283311 0.204138745281397 no 705 0.235048189925257 1223 6849351 SGTC_599 1935-0052 86.5 µM 0.717846012848523 0.205494530211004 no 706 0.236426119388564 1166 9557311 SGTC_2626 ethyl orsellinate 100 µM 0.715814937166642 0.206111472542085 no 707 0.237052813927083 1169 75653 A natural product. SGTC_1075 aripiprazole 15.2 µM 0.71500564636576 0.206357601513308 no 708 0.237302777155414 1215 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1574 spiramycin 23.7 µM 0.71353241928769 0.206806099762312 no 709 0.237758179754885 1192 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3107 9121808 49.47 µM 0.712689642383174 0.20706292773611 no 710 0.23801891357989 1129 662681 SGTC_658 3253-0951 102 µM 0.711172590088649 0.207525709769383 no 711 0.238488645858982 1190 1184878 SGTC_785 1270-0111 65.3 µM 0.708580946811357 0.208317712089193 no 712 0.239292281704625 1192 6741994 SGTC_1713 st033146 12.748 µM 0.708403069853556 0.208372136333805 no 713 0.239347493304075 1169 674619 SGTC_2144 5628481 200 µM 0.708390633302674 0.208375941805229 no 714 0.239351353771249 1173 2818399 SGTC_224 benfluorex 43.875 µM 0.708177109462495 0.208441284551227 no 715 0.239417639653336 1182 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1495 4469-0029 237 µM 0.707347685179354 0.208695220283675 no 716 0.239675219426882 1211 793680 SGTC_1177 0983-0204 23.6 µM 0.706965650754963 0.208812244878875 no 717 0.239793912020989 1210 766818 SGTC_1514 1189-1591 158 µM 0.706867468466396 0.208842326273076 no 718 0.239824421023175 1184 767698 YMR146C TIF34 SGTC_3202 9113761 49.47 µM 0.704811898396835 0.209472704314878 no 719 0.240463651481282 1208 4798415 SGTC_366 0181-0206 4.31 µM 0.704457292350741 0.209581563828572 no 720 0.240574018787606 1189 274874 SGTC_2824 7998404 51.95 µM 0.701005764022361 0.210642875768747 no 721 0.241649709030426 1139 837851 SGTC_100 0086-0128 49.5915 µM 0.699927869269653 0.210974963129996 no 722 0.241986175895943 1173 93297 SGTC_1313 1220-0047 237 µM 0.698342480921182 0.211463960931027 no 723 0.242481519210953 1205 3528706 SGTC_153 4077-0274 519.67 µM 0.696703200727324 0.211970278411429 no 724 0.242994277658015 1269 3121976 SGTC_2557 derrustone 83.84 µM 0.696458123762057 0.212046035169058 no 725 0.243070986843604 1200 629853 An antioxidant. SGTC_730 1436-0052 41.2 µM 0.696170086904236 0.212135091673664 no 726 0.243161159230558 1221 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_906 1165-0455 526 µM 0.692339776210594 0.213321441381861 no 727 0.244361988187909 1196 3252859 SGTC_1827 berberine 7.24 µM 0.68988977319002 0.21408229700861 no 728 0.245131753790797 1137 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2807 7945238 51.95 µM 0.688324983758024 0.214569072326646 no 729 0.245624076034693 1224 17148797 SGTC_1847 st056231 15 µM 0.688016567600637 0.214665090394219 no 730 0.245721174152183 1234 5393180 SGTC_111 0083-0039 52.457 µM 0.686918951694911 0.21500700962423 no 731 0.24606690176827 1134 759313 SGTC_3298 9116858 71.43 µM 0.685411972169781 0.215476964840933 no 732 0.246541995687019 1223 2506942 SGTC_2166 5933061 31.504 µM 0.685028431135882 0.215596668092322 no 733 0.246662990141605 1404 2877375 SGTC_800 3448-7362 155 µM 0.684328415417474 0.215815242557528 no 734 0.246883903807682 1296 15991913 SGTC_378 3970-0959 8.33 µM 0.683711807772881 0.21600787984393 no 735 0.247078582918039 1213 6615653 SGTC_692 k241-0027 77.8 µM 0.68326533673082 0.216147426110137 no 736 0.247219596708598 1252 3600480 SGTC_857 0438-0306 1.35 µM 0.68305751437794 0.216212399599786 no 737 0.247285250171103 1232 4686136 SGTC_2291 7917025 104.35 µM 0.682363568092204 0.216429436572723 no 738 0.247504543267327 1187 2964612 SGTC_908 3448-7491 47.7 µM 0.678898910706881 0.217514918956113 no 739 0.248600957981034 1249 1203031 SGTC_3259 9138485 49.47 µM 0.677633721810385 0.217912086473934 no 740 0.249001979684101 1334 17646153 SGTC_2287 7945887 168.79 µM 0.677333138537441 0.218006506879665 no 741 0.249097304902409 1242 1245853 SGTC_2056 5235370 200 µM 0.676947894158248 0.218127555847393 no 742 0.249219507427251 1208 5511916 SGTC_1635 st007035 42.4 µM 0.674873066164045 0.21878016051377 no 743 0.249878206913463 1244 3716403 SGTC_2979 9012552 45.46 µM 0.674512275269546 0.218893756206824 no 744 0.24999284211373 1283 17100905 SGTC_2852 9023854 51.95 µM 0.674412225386253 0.218925263109464 no 745 0.250024636212445 1290 19798528 SGTC_718 1130-0073 349 µM 0.674032635981916 0.219044824066299 no 746 0.250145282578772 1291 6740020 SGTC_466 geldanamycin 89.2 µM 0.673549524188176 0.219197046222904 no 747 0.250298876513974 1135 5288382 HSP90 inhibitor. SGTC_532 1548-0774 215 µM 0.673220434752052 0.219300772777164 no 748 0.250403531318178 1328 5932993 SGTC_2439 5492030 7.2 µM 0.672794364302078 0.21943510892495 no 749 0.250539061815959 1197 5722370 SGTC_1871 st057448 67.3 µM 0.670289830349641 0.220225720914917 no 750 0.251336524369172 1317 691747 SGTC_720 r052-1644 49.9 µM 0.669197855140815 0.220570937931675 no 751 0.251684637141418 1219 1422863 YOR257W CDC31 SGTC_2414 st077232 92.9 µM 0.667868754751669 0.220991537750857 no 752 0.252108686826173 1202 729801 SGTC_3040 9091894 49.47 µM 0.667063604451307 0.221246554311437 no 753 0.25236575334252 1181 25236966 SGTC_1678 st019265 80.2 µM 0.665997019920131 0.221584634406748 no 754 0.2527065026053 1279 5367020 SGTC_3217 9129673 49.47 µM 0.66401869643226 0.222212493571411 no 755 0.253339172436154 1234 17248312 SGTC_2904 7225135 42.03 µM 0.662200068863732 0.22279056467701 no 756 0.253921505043796 1322 4446116 SGTC_1488 4013-0813 75.9 µM 0.661971463259382 0.222863290104293 no 757 0.253994755241856 1233 2910057 SGTC_1693 xanthone 101.9 µM 0.661750059401628 0.22293373735857 no 758 0.254065708411464 1286 7020 An insecticide. SGTC_3020 9089140 49.47 µM 0.661385342048107 0.223049812385954 no 759 0.254182611844116 1250 17217859 SGTC_1090 efavirenz 20.7 µM 0.660827788011634 0.223227326165997 no 760 0.25436138003425 1270 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_617 3770-0098 35 µM 0.65994409452828 0.223508840728759 no 761 0.254644853044574 1223 5962639 SGTC_184 1494-0393 24.714 µM 0.659162743612257 0.223757920575029 no 762 0.254895634148153 1244 3090647 SGTC_1753 st043925 64 µM 0.658997449271682 0.223810633488872 no 763 0.254948703306973 1263 670181 SGTC_818 4072-2707 53.5 µM 0.657964371444157 0.224140245308477 no 764 0.255280512702601 1203 882871 SGTC_3282 9108498 15.4605 µM 0.657947263140776 0.224145706170372 no 765 0.255286009537544 1228 16459645 SGTC_711 k292-0785 179 µM 0.657438094230428 0.224308264240743 no 766 0.255449631954838 1259 4146315 SGTC_2378 9074213 121.43 µM 0.657007667060426 0.224445735285998 no 767 0.255587993290725 1243 657714 SGTC_1969 st069479 40.1 µM 0.6568917842793 0.224482754423449 no 768 0.255625250638017 1237 3895485 SGTC_144 4161-2749 112.381 µM 0.656674232985851 0.224552261260209 no 769 0.255695202978515 1187 797501 YMR168C CEP3 SGTC_1757 st041620 31.8375 µM 0.65511456919817 0.22505092550809 no 770 0.256196996253796 1259 5289815 SGTC_573 3702-0553 84.7 µM 0.653395813826427 0.225601181448464 no 771 0.256750568436686 1236 1222756 SGTC_2696 st077691 74.316 µM 0.651578819248693 0.22618371541571 no 772 0.257336457595488 1261 757133 SGTC_716 1683-5115 658 µM 0.65067332572973 0.226474336411793 no 773 0.257628692803778 1288 723597 SGTC_2391 6285546 200 µM 0.649575332033332 0.226827023624944 no 774 0.257983285748627 1232 846083 SGTC_2924 9010168 62.78 µM 0.649428595082327 0.226874180548925 no 775 0.25803069306643 1288 2993929 SGTC_215 1287-0124 461.5 µM 0.648936559138953 0.227032346730135 no 776 0.258189691479457 1284 5560863 SGTC_3059 1327-0034 3 µM 0.648501873253283 0.22717212930343 no 777 0.258330199815719 1220 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3096 9117468 49.47 µM 0.645830971423518 0.22803207907543 no 778 0.259194413936665 1185 41316311 SGTC_1689 st020265 53.493 µM 0.643450079628885 0.228800195411388 no 779 0.259966048462105 1288 5758320 YPR016C TIF6 SGTC_2259 7964009 200 µM 0.641875663134678 0.229308925787659 no 780 0.260476958552201 1300 313134 SGTC_1866 st057638 64 µM 0.640849339469193 0.229640895836511 no 781 0.260810286539252 1276 688802 SGTC_2994 9053520 71.4286 µM 0.640537768474599 0.229741728434962 no 782 0.260911521541963 1287 4647384 SGTC_880 0833-0487 87.2 µM 0.639484151495471 0.230082890324703 no 783 0.261254010250945 1254 76075 SGTC_2641 levomentholum 100 µM 0.638043625755097 0.230549791914549 no 784 0.261722641020348 1244 16666 SGTC_393 acivicin 6.25 µM 0.634127317700226 0.231821814035845 no 785 0.26299886807282 1236 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2565 isoliquiritigenin 100 µM 0.633419641807297 0.232052084446621 no 786 0.263229820847966 1241 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2164 5685496 200 µM 0.632760387963506 0.232266713341059 no 787 0.263445064064454 1275 759046 SGTC_3138 9097216 49.47 µM 0.631628589448595 0.232635442921758 no 788 0.26381480025453 1296 25237486 SGTC_521 r062-0005 13.8 µM 0.631190111231895 0.232778382509232 no 789 0.263958113492768 1228 2832033 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.630856392136877 0.232887204351629 no 790 0.264067213602448 1279 2724278 An inhibitor of dopamine biosynthesis. SGTC_1375 2910-0797 186 µM 0.626991302756328 0.234149621245982 no 791 0.265332468111672 1305 742508 SGTC_1983 st071813 46.9 µM 0.626925870827397 0.23417102521292 no 792 0.265353914007302 1295 11838595 SGTC_3186 9110464 49.47 µM 0.625372988223522 0.234679319008769 no 793 0.265863143140561 1318 17018021 SGTC_2189 6047310 154.431 µM 0.625341193947547 0.234689732367906 no 794 0.265873574451953 1243 711535 SGTC_1218 1348-1416 30.7 µM 0.625215697462661 0.234730837857391 no 795 0.265914750331968 1288 6787668 SGTC_3243 9134147 49.47 µM 0.625162598168971 0.234748231355283 no 796 0.265932173387471 1348 24282180 SGTC_2003 4023581 200 µM 0.624477870886877 0.23497258823201 no 797 0.266156899396567 1335 16641307 SGTC_3070 9117005 49.47 µM 0.623913088394014 0.235157733279387 no 798 0.266342332121775 1354 8779016 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.623787883457318 0.235198788436929 no 799 0.266383448997564 1368 688801 SGTC_886 0866-0150 153 µM 0.623457799579882 0.235307043119738 no 800 0.266491862813699 1334 271463 SGTC_1245 0418-0076 17.2 µM 0.623166306453704 0.235402664402469 no 801 0.266587620311553 1325 6790114 SGTC_1290 0986-0249 10.2 µM 0.621989812634518 0.235788818813735 no 802 0.266974283370839 1260 53329 SGTC_2646 retinol 96.75 µM 0.621461360698384 0.235962383434088 no 803 0.267148055000568 1313 445354 A vitamin A analog and teratogen. SGTC_11 0438-0307 1.3 µM 0.620664859793602 0.236224118978244 no 804 0.267410077407409 1328 4011476 SGTC_1937 st074714 47.2 µM 0.619343032714689 0.236658832859999 no 805 0.267845200596589 1265 17250970 SGTC_850 0388-0143 75.9 µM 0.618956155177221 0.236786149826615 no 806 0.267972621595402 1293 67273 SGTC_23 0213-0011 39.996 µM 0.618237238804354 0.237022836968595 no 807 0.268209483089535 1346 627608 SGTC_876 0720-0963 56.8 µM 0.617980432847847 0.23710741609632 no 808 0.26829411851886 1394 765861 SGTC_2200 6600604 21.907 µM 0.617734614525865 0.237188391974779 no 809 0.268375145341212 1273 2904777 SGTC_2945 9067681 61.76 µM 0.617525280483727 0.237257361413543 no 810 0.268444155888589 1380 16456930 SGTC_1581 himbacine 57.9 µM 0.617086664063325 0.237401908396552 no 811 0.268588782221765 1305 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1272 0839-0021 27 µM 0.61700346073074 0.23742933368825 no 812 0.268616221529226 1330 5027250 SGTC_3033 9090887 49.47 µM 0.616537674934171 0.237582897053626 no 813 0.268769857251253 1285 19325384 SGTC_3088 9117578 49.47 µM 0.615464922413484 0.237936776482341 no 814 0.269123863905643 1365 678341 SGTC_1655 st012546 55.1 µM 0.61451729072967 0.238249621313169 no 815 0.26943677537985 1287 720985 YLR208W SEC13 SGTC_2405 ticlatone 3.52 µM 0.614408415486126 0.238285579089256 no 816 0.269472738063647 1213 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1457 k015-0032 57.3 µM 0.614329995319013 0.23831148043485 no 817 0.26949864259306 1329 4302660 SGTC_1575 cyproterone acetate 48 µM 0.614109099462796 0.238384448271442 no 818 0.2695716178174 1270 9880 An androgen receptor antagonist and liver toxin. SGTC_2141 5621638 7.665 µM 0.613387878201641 0.238622772195497 no 819 0.269809949617452 1367 2856238 SGTC_2931 9014674 55.67 µM 0.612979981239618 0.238757617393115 no 820 0.269944788256211 1298 2996810 SGTC_2395 5646831 180.19 µM 0.612973044616281 0.23875991090705 no 821 0.269947081589788 1367 6808628 SGTC_811 0416-0114 265 µM 0.612433957155644 0.238938190776203 no 822 0.270125340401316 1327 6612453 SGTC_2467 5474540 200 µM 0.611432436258249 0.23926959365934 no 823 0.270456667248873 1298 5413519 SGTC_795 0685-0265 78 µM 0.610698439052263 0.239512632428963 no 824 0.270699619806999 1352 302754 SGTC_325 2810-4341 181 µM 0.607769067602886 0.240483937421859 no 825 0.271670323742944 1334 774970 SGTC_1032 k061-1018 98.7 µM 0.607617665991939 0.240534196573049 no 826 0.271720540653491 1469 4005393 SGTC_2715 st079500 56.4 µM 0.606551096032268 0.240888416246771 no 827 0.272074431614958 1282 28246688 SGTC_1681 tripelennamine 100 µM 0.606279365269205 0.240978706372569 no 828 0.272164629274858 1317 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2567 aureobasidin a 60 nM 0.606213494089636 0.241000596680771 no 829 0.272186496634767 1400 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1925 st057770 10.1 µM 0.60619930309723 0.241005312772472 no 830 0.272191207755342 1249 5989122 SGTC_2206 7254556 146.969 µM 0.605993796111094 0.241073614523168 no 831 0.272259436433759 1317 4398905 SGTC_1784 st039334 36.3 µM 0.605792500592302 0.241140526764018 no 832 0.272326275135702 1403 3496984 SGTC_1173 0443-0020 122 µM 0.603779285888883 0.241810290538397 no 833 0.272995196458978 1330 5331295 SGTC_125 0133-0007 11.75 µM 0.603304722213892 0.241968317047239 no 834 0.273152996045544 1407 26541 SGTC_1932 st074806 40.9 µM 0.597156657656361 0.24402063587903 no 835 0.275201396750778 1433 17251235 SGTC_167 3672-0051 66.205 µM 0.59655333934033 0.244222537556051 no 836 0.275402815980735 1288 3237971 SGTC_2350 9023895 38.85 µM 0.596045655261268 0.244392504800422 no 837 0.275572363676325 1398 2997209 SGTC_1167 k781-0610 148 µM 0.595583059249919 0.244547432524275 no 838 0.275726898306446 1383 4525169 SGTC_464 bw-b 70c 158 µM 0.594429405273961 0.244934032382202 no 839 0.276112472940432 1381 5353454 SGTC_3192 9110362 49.47 µM 0.593991955277677 0.245080711769725 no 840 0.276258746812472 1413 16649480 SGTC_395 anisomycin 6.25 µM 0.5935600460416 0.245225579649776 no 841 0.276403205267359 1297 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1220 1838-0075 193 µM 0.593525296421743 0.245237237117389 no 842 0.276414829403614 1286 5529645 SGTC_449 xestospongin c 11.1929 µM 0.593191889817465 0.24534910029371 no 843 0.276526369823207 1347 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_384 k007-0144 5.16 µM 0.592842677623795 0.245466295894593 no 844 0.276643221622167 1374 6824886 SGTC_951 1171-0579 82.7 µM 0.591438571970146 0.245937817160767 no 845 0.277113301196435 1305 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1041 0206-0046 107 µM 0.590049566457364 0.246404745364651 no 846 0.27757870966566 1380 50494 SGTC_2809 7964133 12.99 µM 0.588998148505872 0.246758505785438 no 847 0.277931257815991 1385 1253665 SGTC_9 0092-0002 10.449 µM 0.588869413838526 0.246801838570897 no 848 0.277974438506264 1352 759368 SGTC_701 4424-0219 185 µM 0.587496130516502 0.247264346578148 no 849 0.278435274245587 1387 2911779 SGTC_1212 0520-0165 585 µM 0.587409547495184 0.247293522390639 no 850 0.278464341573324 1547 5403258 SGTC_126 0417-1624 672.48 µM 0.585603468458762 0.24790253480943 no 851 0.279071008507256 1421 41912 YDL195W SEC31 SGTC_2686 alizarin 95.37 µM 0.585577829135043 0.247911186184743 no 852 0.279079625451437 1327 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1657 st012939 43.4 µM 0.585510822999564 0.247933796560103 no 853 0.279102145694069 1393 24207257 SGTC_3354 9151612 71.43 µM 0.585341374909703 0.247990979591173 no 854 0.279159099825535 1390 27261949 SGTC_1124 fisetin 1.16336 µM 0.583339533022305 0.248667066235335 no 855 0.279832377241847 1372 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2746 daunorubicin 9.88 µM 0.582437121463004 0.248972160460352 no 856 0.280136141742881 1310 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_253 dyclonine 31.25 µM 0.581829816071165 0.24917759500948 no 857 0.280340659243649 1424 3180 An oral anasthetic. SGTC_1023 4482-3888 16 µM 0.580602519063165 0.249593030539196 no 858 0.280754187060639 1436 3303168 SGTC_458 nppb 133 µM 0.580054472649997 0.249778661005277 no 859 0.280938942103651 1454 4549 A chloride channel blocker. SGTC_2822 7994718 71.43 µM 0.579872934902097 0.249840166365982 no 860 0.281000154279807 1375 1018011 SGTC_734 2023-0417 80 µM 0.578506352736835 0.25030342515211 no 861 0.281461154824778 1389 3935732 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.578044128044195 0.250460218078751 no 862 0.281617163474805 1360 16623 A steroid. SGTC_1507 4075-3230 155 µM 0.576859923963981 0.250862153646854 no 863 0.282017042543173 1307 659771 SGTC_2232 chlorophetanol 41.5365 µM 0.576203838049857 0.251084985361049 no 864 0.282238705650998 1440 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_376 3970-0862 59.1 µM 0.573074171124964 0.252149378664108 no 865 0.283297237379133 1412 3135186 SGTC_508 roscovitine 141 µM 0.57189698650282 0.252550351804598 no 866 0.28369588286375 1440 160355 A CDKinase inhibitor. SGTC_1672 st016598 6.51 µM 0.57178231697389 0.252589428537469 no 867 0.283734729267415 1338 4665860 YNL267W PIK1 SGTC_2909 7941780 10.49 µM 0.571440614371938 0.252705891794164 no 868 0.283850502386217 1382 1243215 SGTC_164 4100-3994 89.624 µM 0.570999330948971 0.252856337233986 no 869 0.284000048183794 1451 4615967 SGTC_3210 9128157 49.47 µM 0.570931746871685 0.252879382634251 no 870 0.284022954966519 1372 17590849 SGTC_948 3448-0295 75.3 µM 0.570112033033752 0.253158983710993 no 871 0.284300857133849 1389 678569 SGTC_1920 st075728 45.7 µM 0.569149182890459 0.253487615545117 no 872 0.284627451755003 1471 3400306 SGTC_3228 9131799 49.47 µM 0.56826419361951 0.253789870154371 no 873 0.284927794203248 1417 17015818 SGTC_2974 9094440 9.66 µM 0.566067046491354 0.254541089517731 no 874 0.285674101878108 1495 25236134 SGTC_2348 9022543 33.42 µM 0.563755082913884 0.255332821397663 no 875 0.286460412207502 1416 3162678 YDL140C RPO21 SGTC_441 propafenone 146 µM 0.562897556811594 0.255626808116176 no 876 0.28675232199077 1350 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_85 0868-0259 160.055 µM 0.561166871161085 0.256220679174439 no 877 0.287341892437521 1419 83173 SGTC_1338 1486-1223 76 µM 0.559991574731736 0.256624382547876 no 878 0.287742592258065 1466 3444526 SGTC_635 k038-0028 24.7 µM 0.559755226287018 0.256705606022305 no 879 0.287823203613808 1458 4035102 SGTC_966 1300-0360 30.2 µM 0.559531686463589 0.256782440002062 no 880 0.287899456147624 1396 70588 SGTC_2484 5809818 12.04 µM 0.559176390381818 0.256904585206539 no 881 0.288020672194889 1402 2870548 SGTC_572 0960-0087 17.7 µM 0.558572723766721 0.257112185593799 no 882 0.288226679814163 1343 6796365 SGTC_816 0325-0417 81.3 µM 0.55836435814158 0.2571838625861 no 883 0.288297802919931 1374 68101 SGTC_2009 4012297 12.05 µM 0.556849841565354 0.257705162623471 no 884 0.288815013517758 1396 45595307 SGTC_49 0717-0965 32.132 µM 0.556341216980923 0.257880355321952 no 885 0.288988807807513 1475 5889349 YGL099W LSG1 SGTC_1404 3909-7820 48.3 µM 0.556251194882953 0.257911369331149 no 886 0.289019572999032 1407 23741373 SGTC_476 mead acid 10 µM 0.555619818698342 0.258128942590842 no 887 0.289235390072868 1433 5312531 An omega 9 fatty acid. SGTC_2419 paclitaxel 166.5 µM 0.554873466941634 0.258386259307411 no 888 0.289490605766848 1330 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1489 4065-0444 182 µM 0.552225680636242 0.259300196929755 no 889 0.290396870906895 1437 2877968 SGTC_2421 5690543 90.72 µM 0.551713467078317 0.259477190554888 no 890 0.290572340873422 1437 3397993 SGTC_1522 st012842 45.6 µM 0.551088097461636 0.259693369429743 no 891 0.290786642159923 1349 3491067 YOR116C RPO31 SGTC_295 k015-0027 31 µM 0.548797721440095 0.260485903610048 no 892 0.291572137085152 1386 3887424 SGTC_2367 9070478 135.38 µM 0.547097246330849 0.261075120158454 no 893 0.292155961995579 1436 572802 SGTC_1049 3226-0134 66 µM 0.546648384188052 0.261230765614226 no 894 0.292310160742048 1415 5702385 SGTC_2240 6690706 185.951 µM 0.545478136959203 0.261636779451641 no 895 0.292712356607177 1338 805876 SGTC_1035 k081-0041 55.2 µM 0.545004860684623 0.261801073187956 no 896 0.292875087296591 1410 731709 SGTC_1922 5578187 25 µM 0.543431872520975 0.262347502308365 no 897 0.293416242953018 1506 1350412 SGTC_2408 sulbentine 18.36 µM 0.542950281284037 0.26251491555854 no 898 0.293582017528273 1513 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2062 5245942 200 µM 0.541825137747793 0.262906256816872 no 899 0.2939694862433 1460 1376160 SGTC_1370 2001-0092 44.6 µM 0.541600083790071 0.26298456963335 no 900 0.294047017050879 1592 790957 SGTC_2212 7123476 200 µM 0.540530832896551 0.263356803459393 no 901 0.294415501717591 1426 1085715 SGTC_1014 4130-3005 69.3 µM 0.540065065437377 0.263519033203584 no 902 0.294576080875774 1406 743608 SGTC_1742 st038235 28.8875 µM 0.539603092311819 0.263679991722245 no 903 0.294735391795657 1441 564103 YBR002C RER2 SGTC_1134 3477-0009 42.5 µM 0.539357298244529 0.263765650578092 no 904 0.294820169796487 1600 3973534 SGTC_820 1582-0060 59.9 µM 0.539297256023185 0.263786577356712 no 905 0.294840880952949 1400 3848840 SGTC_2589 lobaric acid 100 µM 0.538587055514418 0.264034170871698 no 906 0.295085910662123 1397 73157 A novel microtubule depolymerizer. SGTC_3103 9120822 49.47 µM 0.536558820789276 0.264741915226228 no 907 0.295786197565613 1484 17141819 SGTC_2767 sibutramine 71.45 µM 0.534605708463302 0.26542435646423 no 908 0.296461267718824 1516 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2208 7283366 200 µM 0.534120226202335 0.265594128297551 no 909 0.296629178423575 1491 898663 SGTC_653 0203-0016 55.2 µM 0.53253555529686 0.266148666442846 no 910 0.297177561510549 1472 295302 SGTC_1987 st072290 61.9 µM 0.530629608047959 0.266816407403439 no 911 0.297837737034558 1457 54697379 SGTC_3043 9092303 49.47 µM 0.528373370284834 0.267607963968976 no 912 0.298620108305703 1369 25236084 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.527535373858433 0.267902259694071 no 913 0.298910929135456 1365 6708630 An antioxidant. SGTC_881 0833-0569 170 µM 0.52742398697634 0.267941389890867 no 914 0.29894959486342 1391 5418700 SGTC_428 3448-4153 16.5 µM 0.526711769627717 0.268191659769071 no 915 0.299196880553222 1374 3834874 SGTC_3066 9117245 49.47 µM 0.525997583490744 0.268442739533601 no 916 0.299444942984391 1542 17176980 SGTC_685 1278-0033 54.9 µM 0.525247816944309 0.268706455080524 no 917 0.299705464050266 1515 3590572 SGTC_480 am 92016 50 µM 0.524091262134215 0.269113505432603 no 918 0.300107532857871 1375 2129 K+ channel blocker. SGTC_1810 st050138 53 µM 0.521775470536546 0.269929478992295 no 919 0.300913335218695 1459 3444541 SGTC_2090 5301565 104.445 µM 0.520335855717083 0.270437353444203 no 920 0.301414754566304 1468 2056344 SGTC_2266 7929956 200 µM 0.519157247846749 0.270853503785565 no 921 0.301825544689776 1441 2967153 SGTC_2340 7987427 183.45 µM 0.518941009741169 0.270929889190883 no 922 0.301900939286241 1492 2239331 SGTC_1263 0774-1208 64.8 µM 0.516969935478729 0.271626659902925 no 923 0.302588573064059 1560 906585 SGTC_2674 ligustilide 100 µM 0.516372181769234 0.271838140789078 no 924 0.302797245509646 1440 5319022 A signalling regulator. SGTC_3337 9144342 33.5465 µM 0.516355604569038 0.271844006848454 no 925 0.302803033434935 1526 17682949 SGTC_3239 9133757 49.47 µM 0.516035541235264 0.271957277796468 no 926 0.302914793178807 1516 17036923 SGTC_783 0848-0141 92.7 µM 0.515387768927796 0.272186597307884 no 927 0.303141038851371 1441 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_775 4577-0580 57.3 µM 0.51523934565937 0.272239154534479 no 928 0.303192888883209 1512 2006902 SGTC_1914 st062367 72.6 µM 0.515048014854136 0.272306912918109 no 929 0.303259734040167 1446 978205 SGTC_414 piperonyl butoxide 100 µM 0.514927269185002 0.272349678412095 no 930 0.303301922290584 1421 5794 A potent inhibitor of cytochrome P450. SGTC_2429 5902844 64.44 µM 0.514555803797304 0.272481264303536 no 931 0.303431727862287 1532 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1183 1254-0324 198 µM 0.514306370172476 0.272569640036024 no 932 0.303518904348437 1523 5799357 SGTC_350 k064-0020 19.8 µM 0.513377996003802 0.272898693199885 no 933 0.303843467262166 1541 2790705 SGTC_2079 5212404 121 µM 0.513264703791895 0.272938862001882 no 934 0.303883085219727 1535 758462 SGTC_2861 9024595 19.48 µM 0.511939932118627 0.273408789525225 no 935 0.304346524904319 1440 16482810 SGTC_2227 7312221 64.1025 µM 0.510926619003783 0.273768505605193 no 936 0.30470122051629 1475 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1627 st003713 25.6 µM 0.509909489966281 0.274129811531766 no 937 0.305057436558982 1461 16195070 YER133W GLC7 SGTC_3111 9122088 49.47 µM 0.509793422084914 0.274171056287702 no 938 0.305098097274959 1435 16876704 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.509114076887825 0.274412523259979 no 939 0.305336132645871 1400 88881 An O-methylated flavonoid and antioxidant. SGTC_2959 9079155 11 µM 0.509065050177916 0.274429953410949 no 940 0.305353314273033 1468 16189457 SGTC_442 cape 100 µM 0.508521528627619 0.27462322473245 no 941 0.305543822524561 1566 5281787 SGTC_2303 7774051 200 µM 0.507464590270077 0.274999254513578 no 942 0.305914437834379 1551 2953184 SGTC_1647 st011722 22.4 µM 0.506792948964838 0.275238337870918 no 943 0.306150052119857 1486 2854783 SGTC_1812 st052057 4.327 µM 0.506467635157857 0.275354176212319 no 944 0.306264202261465 1430 3645418 SGTC_2040 5100729 123 µM 0.504623987174736 0.276011118686272 no 945 0.306911479411912 1508 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1076 itraconazole 331 nM 0.504274929625364 0.276135584090688 no 946 0.307034096162422 1470 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1467 k284-1082 293 µM 0.504192493009365 0.276164982997572 no 947 0.307063057604329 1544 3334705 SGTC_662 k832-1615 104 µM 0.504109189095355 0.276194692764597 no 948 0.307092324966214 1525 5878478 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.503574969490484 0.276385255782619 no 949 0.307280042816093 1431 390807 SGTC_1165 k072-0275 30.3 µM 0.503308119851034 0.276480468634286 no 950 0.307373829241004 1478 6153523 YGL055W OLE1 SGTC_29 0299-0004 12.984 µM 0.502970174981187 0.276601071580683 no 951 0.307492620726996 1409 16871 A napthoquinone isolated from Swertia calycina. SGTC_2753 fluvastatin 17.09 µM 0.501170055408034 0.277243917384642 no 952 0.30812572335385 1511 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1430 4049-0248 69.1 µM 0.499935127306716 0.277685348289026 no 953 0.308560378522348 1570 22774488 SGTC_2102 5377816 72.7585 µM 0.499510660162723 0.277837155322297 no 954 0.308709839386355 1559 1379702 SGTC_2073 5212005 126 µM 0.499153501056689 0.277964921594261 no 955 0.308835624695388 1410 691789 SGTC_2313 7726885 200 µM 0.498239884190992 0.278291879525225 no 956 0.309157486908535 1485 726423 SGTC_668 1682-0499 62.6 µM 0.496402087450165 0.27895014292466 no 957 0.30980537629965 1494 682214 SGTC_2058 5236698 133 µM 0.495929079931778 0.279119687586648 no 958 0.30997222419649 1504 766665 SGTC_39 0986-0283 58.349 µM 0.494653290971716 0.279577230615424 no 959 0.310422438993174 1617 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1703 st026983 48.3 µM 0.49306848964397 0.280146102996333 no 960 0.310982097300138 1565 1104023 SGTC_660 4031-1742 102 µM 0.491067542440754 0.280865153215281 no 961 0.311689338539495 1478 6738706 SGTC_1604 st002052 72.4 µM 0.489295995413541 0.281502511085167 no 962 0.312316077895879 1511 6254834 YHR062C RPP1 SGTC_2444 5485484 36.41 µM 0.487762934796045 0.282054630137901 no 963 0.312858884064823 1590 6790631 SGTC_1943 st076331 65.2 µM 0.487221820380381 0.282249632438056 no 964 0.313050571824026 1530 24208415 SGTC_1725 st036284 20.55 µM 0.486295952256261 0.282583439471418 no 965 0.313378674351329 1662 707914 SGTC_2971 9092186 9.93 µM 0.485956928884556 0.282705716408373 no 966 0.313498851999936 1391 25236400 SGTC_2619 obliquin 87.91 µM 0.485712442903337 0.282793911936063 no 967 0.31358553014396 1569 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2260 7964312 200 µM 0.484759521349372 0.283137793608616 no 968 0.313923469697607 1598 231951 SGTC_1240 0356-0016 42.1 µM 0.482516983395925 0.283947851110761 no 969 0.314719368340822 1549 4305613 SGTC_117 lucigenin 22.078 µM 0.482344461249215 0.284010216085612 no 970 0.314780633871531 1450 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.47933063596088 0.285100738640292 no 971 0.315851715422833 1502 4620898 SGTC_177 1327-0068 8.361 µM 0.477952156635969 0.285600192017029 no 972 0.316342128889457 1485 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1360 1598-0022 39.8 µM 0.477765581589169 0.285667824240281 no 973 0.316408530444142 1596 761525 SGTC_2645 abamectin 100 µM 0.477419082066806 0.285793448243892 no 974 0.316531864390248 1551 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1980 st071811 45.7 µM 0.477117843655398 0.285902684098398 no 975 0.316639104558979 1555 4974850 SGTC_3000 9075062 71.4286 µM 0.471839376361368 0.287819989315289 no 976 0.318520721273654 1503 17057871 SGTC_1768 st044301 37.178 µM 0.471321737748037 0.288008338445745 no 977 0.318705497348986 1489 3931349 SGTC_1811 st050069 61.5 µM 0.470199431479604 0.288416902985585 no 978 0.319106270146617 1534 3877702 SGTC_2989 9073649 71.4286 µM 0.46964152783912 0.288620103920342 no 979 0.319305574902178 1565 21367202 SGTC_1052 3253-3998 198 µM 0.469468148550605 0.288683266252168 no 980 0.319367523328576 1488 5450317 SGTC_2375 9072683 200 µM 0.469137455281713 0.288803756346226 no 981 0.319485694026172 1657 16798029 SGTC_738 1315-0003 72.4 µM 0.468670720094715 0.288973854411833 no 982 0.319652509454802 1593 6251474 SGTC_394 menadione 8.33 µM 0.467760090486047 0.289305862026053 no 983 0.319978081848591 1533 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2718 lomofungin 53.02 µM 0.467486399914691 0.289405682245309 no 984 0.320075960051793 1620 5351222 A RNA synthesis inhibitor. SGTC_2838 9002687 71.43 µM 0.466019007437526 0.289941144257959 no 985 0.320600947646432 1485 6457060 SGTC_189 3970-0742 2.116 µM 0.464814599793217 0.290380988065042 no 986 0.321032115800417 1570 2891807 SGTC_2027 5150920 200 µM 0.46349503287867 0.290863245817456 no 987 0.321504787199159 1585 786715 SGTC_65 0798-0905 34.986 µM 0.463050300046932 0.291025865162254 no 988 0.321664156539281 1729 3602145 SGTC_941 3237-0776 460 µM 0.462594858510037 0.291192444219738 no 989 0.321827397345475 1628 760008 SGTC_151 3013-0144 2.285 µM 0.462317719138068 0.291293830527142 no 990 0.321926747356731 1605 906558 YHR107C CDC12 SGTC_191 3914-0123 66.505 µM 0.461612041018632 0.29155206415933 no 991 0.322179779084562 1469 3144412 SGTC_330 1488-0319 80.1 µM 0.461256607095521 0.291682170943855 no 992 0.322307256600902 1561 6846614 SGTC_984 1492-0255 2.91 µM 0.460812866249936 0.291844640498725 no 993 0.322466435012239 1573 1585198 SGTC_416 estradiol valerate 100 µM 0.4587164544682 0.292612782049459 no 994 0.323218898171643 1542 13791 A steroid. SGTC_1144 3486-0183 12.5 µM 0.457436632430054 0.293082180045503 no 995 0.323678619577969 1547 6744069 SGTC_544 k015-0020 52.4 µM 0.456314175346994 0.293494148838985 no 996 0.324082035963574 1554 3008304 SGTC_1926 methyl fluorone black 53.6 µM 0.456283675245363 0.293505346853134 no 997 0.324093000730527 1449 72721 Reacts with homocysteine. SGTC_370 0180-0345 38.7 µM 0.455753247362993 0.293700123379205 no 998 0.324283713609398 1524 3989527 SGTC_1142 3253-1408 9.78 µM 0.455614400485085 0.293751118722381 no 999 0.324333642975096 1558 256655 SGTC_302 1094-0063 18.9 µM 0.455593652822649 0.293758739225164 no 1000 0.324341104110032 1500 5440289 SGTC_911 3456-4043 236 µM 0.454516725870883 0.294154414137002 no 1001 0.324728478121798 1638 914281 SGTC_166 k072-0058 166.424 µM 0.454467419185676 0.294172535854496 no 1002 0.324746218434775 1576 5846229 SGTC_3245 9134821 49.47 µM 0.453695470172522 0.294456318000364 no 1003 0.3250240138623 1474 17014901 SGTC_1904 st060225 78 µM 0.453046200263428 0.294695098923283 no 1004 0.325257737039248 1506 66595 SGTC_2403 6032726 181.2 µM 0.452590575507404 0.294862716592039 no 1005 0.325421793194781 1524 2881040 SGTC_2914 7968218 45.32 µM 0.450817827683873 0.295515302247977 no 1006 0.326060425638954 1621 2977111 SGTC_726 3448-4391 34.2 µM 0.450753565775241 0.29553897087383 no 1007 0.326083585592558 1662 1356692 SGTC_170 4197-0004 226 µM 0.449269162318617 0.2960859414001 no 1008 0.32661875028588 1601 218692 SGTC_2274 7947094 46.08 µM 0.448934517711132 0.296209314832971 no 1009 0.326739447413151 1508 2971028 SGTC_421 streptovitacin 30 mM 0.448600754410961 0.296332386837325 no 1010 0.326859844739607 1566 91467 include heat shock SGTC_1712 st032288 53.4 µM 0.447491713288118 0.296741503368504 no 1011 0.327260034877811 1531 2883011 SGTC_723 4182-0001 115 µM 0.447098658411778 0.296886560256404 no 1012 0.327401913824593 1529 744821 YLR208W SEC13 SGTC_3287 9117173 37.0625 µM 0.445312462630759 0.297546164143818 no 1013 0.328046981371027 1550 2789709 SGTC_535 2293-4129 48.2 µM 0.44362624280744 0.298169462232246 no 1014 0.328656414592795 1671 396118 YIL048W NEO1 SGTC_687 k029-0044 34.9 µM 0.442914999006341 0.298432546204352 no 1015 0.328913609013086 1685 5829338 SGTC_2877 9040724 71.43 µM 0.442592182684136 0.2985519884845 no 1016 0.329030370069276 1666 6463895 SGTC_2441 5730946 39.09 µM 0.442130432887014 0.298722874039226 no 1017 0.329197411668083 1646 1774275 SGTC_2216 7189485 200 µM 0.441332591652411 0.299018245915549 no 1018 0.329486117331808 1636 731273 SGTC_519 k048-0011 62.8 µM 0.441237933947232 0.299053298308074 no 1019 0.329520376780687 1609 6836379 SGTC_1606 st000094 49.2 µM 0.439596304502814 0.299661501366223 no 1020 0.330114758862567 1688 1242210 SGTC_2757 clomiphene 4.22 µM 0.438984661736117 0.299888250516935 no 1021 0.330336325144836 1714 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2842 9000675 19.48 µM 0.438630886770499 0.300019437960378 no 1022 0.330464506532493 1488 2989072 SGTC_3229 9132204 49.47 µM 0.433605004990505 0.301885941555273 no 1023 0.332287649834306 1618 17682924 SGTC_706 4262-0057 46.9 µM 0.431169015657468 0.302792488610369 no 1024 0.333172740646469 1534 883298 SGTC_134 0269-0018 6.916 µM 0.430785136844068 0.302935459234039 no 1025 0.333312303875649 1522 4378915 SGTC_2735 sertaconazole 140 nM 0.429290379876365 0.303492449492226 no 1026 0.333855958445517 1651 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3163 9099914 49.47 µM 0.427278324009247 0.304242921837649 no 1027 0.334588309428347 1636 16268368 SGTC_2636 apigenin dimethyl ether 100 µM 0.427178383736043 0.304280219882284 no 1028 0.334624702272746 1606 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2033 5192550 145 µM 0.426216745355292 0.304639210557254 no 1029 0.334974958339366 1558 182073 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.425999295796331 0.304720413085906 no 1030 0.335054179572134 1625 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3180 9109287 49.47 µM 0.425646539438487 0.304852163908144 no 1031 0.335182711391883 1580 18891271 SGTC_1769 st044406 64.4 µM 0.424388972398112 0.305322057925016 no 1032 0.335641080869858 1589 670903 SGTC_798 1287-0182 476 µM 0.424191528223407 0.305395862756664 no 1033 0.335713069359624 1716 1649755 SGTC_2001 4023502 57.655 µM 0.42361013560808 0.305613233836539 no 1034 0.33592508112795 1637 108941 YCR052W RSC6 SGTC_2135 5326629 150.42 µM 0.423331202266995 0.305717545768371 no 1035 0.336026816046514 1549 5020077 SGTC_3023 9089636 49.47 µM 0.423302755943786 0.305728184647457 no 1036 0.336037191904391 1659 17249241 SGTC_1569 carminic acid 40.6 µM 0.422465782123853 0.306041284868731 no 1037 0.336342535804232 1680 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2582 agaric acid 100 µM 0.419391420785765 0.307192575895487 no 1038 0.337465046516428 1527 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_44 0929-0055 61.211 µM 0.419388518311944 0.307193663718732 no 1039 0.337466106953238 1548 1379590 SGTC_133 0724-0033 378.92 µM 0.417473239444312 0.307911864029181 no 1040 0.338166147077874 1550 280309 SGTC_2856 9022925 19.48 µM 0.417138076729959 0.308037620714616 no 1041 0.338288707675869 1618 4944862 SGTC_1033 k072-0102 21.3 µM 0.416554123489994 0.308256780152479 no 1042 0.338502285659853 1716 5965931 SGTC_148 3253-0744 288.01 µM 0.415948627444131 0.308484096870835 no 1043 0.338723797686189 1562 6893655 SGTC_814 3342-0569 96 µM 0.415932948613763 0.308489984029119 no 1044 0.338729534302338 1617 4346283 SGTC_2623 humulene 100 µM 0.415462133015602 0.308666790937414 no 1045 0.338901815109001 1559 6187145 An anti-inflammatory. SGTC_1374 2889-5571 141 µM 0.415125228657606 0.30879333695814 no 1046 0.339025115814026 1585 2853281 SGTC_1780 st038448 24.544 µM 0.413269658377775 0.309490721865168 no 1047 0.339704528646236 1716 728868 YDL195W SEC31 SGTC_2126 5251174 33.877 µM 0.413076772472262 0.309563254228694 no 1048 0.339775183320196 1792 790722 SGTC_1755 st041960 45.185 µM 0.412943186535747 0.309613491918839 no 1049 0.339824119541026 1615 2257073 SGTC_2706 st078239 82.5 µM 0.411856697526776 0.310022220114273 no 1050 0.340222230697348 1605 15434492 SGTC_1040 k898-0338 155 µM 0.411224130911737 0.31026029467124 no 1051 0.340454097767032 1789 20969351 SGTC_1865 st057639 52.2 µM 0.411101650206735 0.310306401049362 no 1052 0.340498999999409 1600 688818 SGTC_2508 celastrol 40.54 µM 0.40934530436842 0.310967883796224 no 1053 0.34114313633871 1554 122724 Celastrol is a natural product and antioxidant. SGTC_505 gw-5074 63.9 µM 0.408771662603945 0.311184063822213 no 1054 0.341353618758186 1687 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2358 9037157 4 µM 0.40846999436303 0.311297775287122 no 1055 0.341464327615283 1653 2388925 SGTC_586 0957-0265 8.15 µM 0.407383386000659 0.311707512939255 no 1056 0.341863213695745 1635 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3311 9131146 2.8755 µM 0.406215174043236 0.312148281785166 no 1057 0.342292252861209 1607 4900406 YPR165W RHO1 SGTC_1241 0364-0022 50.8 µM 0.405815097422094 0.312299293419851 no 1058 0.342439232401827 1664 4563895 SGTC_2101 5377231 179.231 µM 0.405683591929452 0.312348937947866 no 1059 0.342487549902158 1699 2844213 SGTC_1878 temozolomide 1 mM 0.405433947860458 0.312443190241646 no 1060 0.342579280746681 1748 5394 DNA alkylating agent. SGTC_2490 carminic acid 95.39 µM 0.405295403562936 0.312495502478788 no 1061 0.342630192373294 1610 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1237 0330-0133 46.1 µM 0.404805531869176 0.31268050093655 no 1062 0.342810231108816 1614 X1237 YHR072W ERG7 SGTC_1831 st055328 12 µM 0.398398383095183 0.315104471652199 no 1063 0.345168274795586 1721 1103068 SGTC_576 1073-0113 22.7 µM 0.39779222061431 0.315334211736731 no 1064 0.345391676069636 1704 5439563 SGTC_1658 st012944 20 µM 0.394548446164319 0.316564838318402 no 1065 0.346588083473408 1697 24207260 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.391430097443675 0.317749798439994 no 1066 0.3477396744519 1622 75037 A free radical scavenger. SGTC_1942 st076330 65.2 µM 0.391255265477928 0.317816289335488 no 1067 0.347804280771683 1673 24208414 SGTC_161 4065-0411 162.148 µM 0.390703499105226 0.318026171862939 no 1068 0.348008206068803 1693 1906281 YLR208W SEC13 SGTC_2110 5483698 200 µM 0.390624114355666 0.318056373280976 no 1069 0.348037549204468 1654 2848765 YHR062C RPP1 SGTC_2942 9052777 62.25 µM 0.390276618877335 0.318188589941466 no 1070 0.348166005324936 1685 6469503 SGTC_2834 9001755 58.44 µM 0.390181508068764 0.318224782173912 no 1071 0.348201167281664 1639 2989575 SGTC_669 0108-0021 26.2 µM 0.389193157046198 0.318600979106718 no 1072 0.348566632548078 1901 17201 SGTC_2917 7979103 53.79 µM 0.388528544070113 0.318854056554102 no 1073 0.34881246739365 1729 2980565 SGTC_2194 5927483 104.545 µM 0.388218055989037 0.318972316027088 no 1074 0.348927336131644 1664 760979 SGTC_2183 6420625 130.508 µM 0.388048408201493 0.319036939685608 no 1075 0.348990105187613 1603 2897619 SGTC_1714 st033236 13.627 µM 0.387341742139201 0.319306188010963 no 1076 0.349251613465188 1742 2916566 SGTC_1667 st014849 34.6 µM 0.3856490013922 0.319951530158381 no 1077 0.349878318673029 1657 5348460 SGTC_70 0141-0289 43.283 µM 0.385622661056119 0.319961576487143 no 1078 0.349888073921308 1730 352408 SGTC_590 k048-0076 22.4 µM 0.382994311662528 0.320964704279372 no 1079 0.350861990874423 1736 6832814 SGTC_2890 9046729 58.44 µM 0.378632226018525 0.322632409426504 no 1080 0.352480493987448 1595 903329 SGTC_2785 7756463 72.73 µM 0.376093443493041 0.323604680441499 no 1081 0.353423714226054 1600 2201551 SGTC_1147 3809-1045 12.3 µM 0.375665805507141 0.323768570656399 no 1082 0.353582681081555 1632 325925 SGTC_1117 retinoic acid 1.10837 µM 0.375222882166511 0.323938354944184 no 1083 0.353747356922499 1783 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1628 st004252 77.7 µM 0.374989555426952 0.324027810019711 no 1084 0.353834117202574 1775 692968 SGTC_2984 9022109 38.96 µM 0.373422670352612 0.324628800718837 no 1085 0.354416944650481 1695 6459207 SGTC_1734 st037168 69.4 µM 0.372813802836618 0.324862459848821 no 1086 0.354643514559135 1644 708907 SGTC_103 0844-0104 51.839 µM 0.372737369437506 0.324891796817393 no 1087 0.354671960355929 1757 5375804 SGTC_1304 1165-0502 251 µM 0.372639886764021 0.324929214577188 no 1088 0.35470824112104 1688 767425 SGTC_1463 k081-0032 34.1 µM 0.372429890813375 0.325009825445176 no 1089 0.354786401166661 1587 977755 SGTC_606 k015-0008 38.6 µM 0.370753608971168 0.325653590989276 no 1090 0.355410528609041 1780 1970475 SGTC_1806 st050005 60.3 µM 0.370593605461079 0.325715066568317 no 1091 0.355470122779451 1643 5194765 SGTC_568 1193-0097 7.48 µM 0.36953535466913 0.326121780554066 no 1092 0.355864362910999 1696 3646150 SGTC_644 1498-1197 63.3 µM 0.369388860649606 0.326178098425192 no 1093 0.355918949866653 1727 6741615 SGTC_2077 5212015 200 µM 0.367172342166293 0.327030695542567 no 1094 0.356745234232027 1602 780900 SGTC_1530 rhein 70.4 µM 0.364482095341418 0.328066728858746 no 1095 0.357749020757335 1695 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2495 cafestol 54.53 µM 0.363720500700614 0.328360265260861 no 1096 0.358033366532255 1725 16667697 An anti-infammatory. SGTC_1721 st082152 9.2685 µM 0.363105742595597 0.328597284742777 no 1097 0.358262947500455 1632 5296051 SGTC_998 3996-0085 177 µM 0.362627540606521 0.328781702829293 no 1098 0.358441567130532 1797 715391 SGTC_2075 5212009 200 µM 0.362591341454302 0.328795664691992 no 1099 0.358455089622389 1762 780898 SGTC_2730 imipramine 71.33 µM 0.360907447864891 0.329445399250366 no 1100 0.35908431786421 1763 3696 A tricyclic antidepressant. SGTC_957 1187-1561 14.1 µM 0.360795503834491 0.329488611422171 no 1101 0.359126162080664 1679 1538454 SGTC_129 0088-0017 176.636 µM 0.359974305020488 0.329805676782544 no 1102 0.359433174451788 1791 182446 SGTC_1342 1486-1464 234 µM 0.359116245158251 0.330137104915944 no 1103 0.359754064618314 1671 3253938 SGTC_803 4488-1585 147 µM 0.358896494325834 0.330222005775542 no 1104 0.359836261141394 1767 747204 SGTC_625 k213-0058 121 µM 0.357286745423133 0.330844199520117 no 1105 0.360438575833638 1749 3655420 SGTC_326 k292-0812 17.5 µM 0.351461810941307 0.333099526828596 no 1106 0.362620958874359 1818 3579357 SGTC_1680 diphenhydramine 100 µM 0.351118697148845 0.33323256479762 no 1107 0.362749650776192 1695 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1590 st077108 57.8 µM 0.350753721656723 0.33337410239405 no 1108 0.362886559377143 1829 5489485 SGTC_2364 9055074 200 µM 0.34995371183457 0.333684429407189 no 1109 0.363186718152327 1640 6470630 SGTC_1397 3532-0190 20.1 µM 0.349824256809325 0.333734656233897 no 1110 0.363235296788091 1727 5322280 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.349621181478405 0.333813452762112 no 1111 0.36331150623831 1740 6708739 YPR165W RHO1 SGTC_2956 9076196 2.52 µM 0.348646513166902 0.334191741855371 no 1112 0.363677351854292 1721 16423868 SGTC_3021 9087658 49.47 µM 0.348599160910626 0.334210124547919 no 1113 0.3636951288811 1762 25237042 SGTC_2023 5144124 124 µM 0.347681245368219 0.334566548482484 no 1114 0.364039791499223 1676 2830192 SGTC_2190 6049624 200 µM 0.346242115678901 0.335125658484515 no 1115 0.364580383055447 1765 2265554 SGTC_1163 k060-0048 49.9 µM 0.344095148883621 0.335960446328019 no 1116 0.365387365518813 1710 6809982 SGTC_452 diindolylmethane 8 µM 0.343835996139636 0.33606126546406 no 1117 0.365484813912248 1747 3071 Inhibits expression of several cancer promoting factors. SGTC_1491 4138-0063 26.5 µM 0.343228247214481 0.336297746496997 no 1118 0.365713377884797 1814 23883227 SGTC_1905 st060207 84.5 µM 0.342995841801132 0.336388194838721 no 1119 0.365800794191885 1704 1948547 SGTC_2666 tannic acid 100 µM 0.341623622500798 0.336922432756824 no 1120 0.366317078736515 1738 16134267 A thiamine antagonist. SGTC_391 gliotoxin 8.33 µM 0.338459869377674 0.338155410659839 no 1121 0.367508332009505 1766 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1808 st050063 61.5 µM 0.336715770345622 0.338835864972644 no 1122 0.368165586945547 1797 4011993 SGTC_257 daunorubicin 18.5 µM 0.336012348754057 0.339110451572354 no 1123 0.368430777190474 1849 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2603 homopterocarpin 100 µM 0.335687125162927 0.339237434273473 no 1124 0.368553407824068 1711 101795 A weak amylase inhibitor. SGTC_298 1391-0729 10 µM 0.335289071199816 0.339392878254902 no 1125 0.368703518507378 1724 3237558 SGTC_2120 5538279 151.968 µM 0.334432958738971 0.339727291156531 no 1126 0.36902643612504 1752 2058197 SGTC_1295 1013-0063 9.78 µM 0.333632346056771 0.34004013904696 no 1127 0.369328503420118 1860 6826038 SGTC_1255 0566-0045 221 µM 0.332773029361886 0.3403760487415 no 1128 0.369652809239144 1783 2788469 SGTC_199 4063-0024 41.6 µM 0.330365175599737 0.341317960747563 no 1129 0.3705620257863 1822 306215 SGTC_2450 5739737 12.93 µM 0.329984700193651 0.341466887016212 no 1130 0.370705761351128 1739 2262825 SGTC_443 clozapine 122 µM 0.32948568774227 0.34166224865775 no 1131 0.370894305059862 1845 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_591 4299-0174 154 µM 0.328674391713337 0.341979958763873 no 1132 0.371200906177213 1781 5509088 SGTC_1603 st002045 67.8 µM 0.327118507536866 0.342589568621968 no 1133 0.371789127102841 1842 5887985 SGTC_487 nimodipine 119 µM 0.326685728873562 0.3427592083085 no 1134 0.371952797623963 1831 4497 L-type voltage-gated calcium channels inhibitor SGTC_88 0180-0332 8.668 µM 0.325949347611945 0.343047926384182 no 1135 0.372231339352645 1753 3101745 SGTC_2442 5158906 48.48 µM 0.325242191357785 0.343325272290783 no 1136 0.372498889441595 1831 1893835 SGTC_2156 5649887 115 µM 0.3238256970977 0.343881073504035 no 1137 0.373035000060644 1848 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1960 st011366 51.8 µM 0.323435805130113 0.344034117835311 no 1138 0.373182608446332 1728 3972846 SGTC_1793 st048256 72.231 µM 0.322929195241979 0.344233015633609 no 1139 0.373374432631258 1751 672022 SGTC_2851 9015922 71.43 µM 0.322917009067129 0.344237800523129 no 1140 0.373379047225313 1825 2996893 SGTC_2930 9013230 14.89 µM 0.32276422009068 0.344297795079781 no 1141 0.373436906060351 1843 2995857 SGTC_2470 5664817 21.68 µM 0.32237736673454 0.344449715542753 no 1142 0.373583414231013 1749 2859561 SGTC_2476 5806916 10.51 µM 0.321725059612752 0.344705938689114 no 1143 0.373830495783874 1791 2870194 SGTC_1150 3909-7983 10.9 µM 0.321611321673378 0.34475062171091 no 1144 0.373873582867942 1718 23965914 SGTC_141 0443-0274 32.331 µM 0.32138940906399 0.344837808406211 no 1145 0.373957654052523 1886 1627241 SGTC_2810 7959871 45.46 µM 0.320581486583729 0.345155300650255 no 1146 0.374263784627697 1800 2974535 SGTC_3301 9125354 19.7965 µM 0.318007420598141 0.346167566820546 no 1147 0.375239654029735 1705 41905162 SGTC_115 0527-0192 112.043 µM 0.316294179253379 0.346841919045091 no 1148 0.375889614418299 1753 4233931 SGTC_3029 9088683 49.47 µM 0.315753223442942 0.347054946646884 no 1149 0.376094912619085 1777 25236615 SGTC_515 4092-1064 102 µM 0.315656014919565 0.347093232346344 no 1150 0.376131807955545 1890 717353 SGTC_2413 inermin 26.06 µM 0.314928084467265 0.347379978252916 no 1151 0.376408128730704 1885 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2237 6667747 47.222 µM 0.312249748512344 0.348435777721704 no 1152 0.377425363446083 1720 729940 YDL015C TSC13 SGTC_3087 9117406 49.47 µM 0.312174251831707 0.348465555567048 no 1153 0.377454049526157 1761 42546093 SGTC_2071 5230951 39.92 µM 0.309543067563895 0.349503945049982 no 1154 0.378454228231958 1850 1799272 SGTC_3356 9151811 4.48 µM 0.309219791366947 0.34963160300076 no 1155 0.378577169910552 1737 1859254 YPR165W RHO1 SGTC_2252 omeprazole 400 µM 0.308681752663146 0.349844105826062 no 1156 0.378781812842248 1843 4594 A proton pump inhibitor. SGTC_374 0880-0231 82.3 µM 0.30832635069908 0.349984500569666 no 1157 0.378917008565336 1830 6833587 SGTC_2855 9016525 58.44 µM 0.30617567432636 0.350834521083998 no 1158 0.379735446334461 1753 43811474 SGTC_2863 9028737 58.44 µM 0.305861874871825 0.350958607870953 no 1159 0.379854907556854 1896 6460917 SGTC_1399 3562-5772 25 µM 0.303128887919919 0.35203999303911 no 1160 0.380895819917519 1767 23847490 SGTC_2734 clemastine 41.6 µM 0.301983369011351 0.352493607394713 no 1161 0.381332370530442 1832 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1392 3455-1037 33.9 µM 0.300884187031399 0.35292907009921 no 1162 0.381751404415248 1864 981132 SGTC_744 1594-0068 283 µM 0.300640728804462 0.353025546985394 no 1163 0.381844235153089 1757 668392 SGTC_2941 9056145 11.23 µM 0.300122194616063 0.35323106162605 no 1164 0.382041975127677 1861 2119517 SGTC_852 0418-0143 439 µM 0.299636518370452 0.353423592254801 no 1165 0.382227212831203 1885 5369229 SGTC_3122 9126309 49.47 µM 0.299481618034279 0.353485005372015 no 1166 0.382286297741441 1919 17591206 SGTC_1794 st048918 76.9 µM 0.299272173442668 0.353568049638454 no 1167 0.382366192274447 1899 672303 SGTC_93 0109-0045 59.227 µM 0.298331634105139 0.353941057055871 no 1168 0.382725031202142 1894 88733 SGTC_3353 9151644 39.2805 µM 0.296489662047719 0.354671968597542 no 1169 0.383428080376131 1790 4909158 SGTC_582 0987-0078 156 µM 0.296365394708841 0.354721298333673 no 1170 0.383475524943651 1846 1625765 SGTC_372 0155-0182 15.9 µM 0.296338218535369 0.354732086637548 no 1171 0.383485900885931 1844 771486 SGTC_2070 5230947 200 µM 0.294800090332592 0.355342877153232 no 1172 0.384073298711935 1896 2835538 SGTC_3115 9123671 49.47 µM 0.294715312721201 0.355376553156242 no 1173 0.384105682304964 1838 3286988 SGTC_2729 fluphenazine 10.66 µM 0.294352930926814 0.355520513916546 no 1174 0.384244115051623 1745 3372 An atypical antipsychotic. SGTC_3140 9094243 49.47 µM 0.293608748367918 0.355816214484671 no 1175 0.384528445029685 1976 19291112 SGTC_417 st075190 100 µM 0.293567792383693 0.355832490845308 no 1176 0.384544094895847 1925 222757 SGTC_2783 7738165 71.43 µM 0.291517924297277 0.356647466258397 no 1177 0.385327618640089 1690 17201110 SGTC_2275 7947463 200 µM 0.286420560873142 0.358676880448561 no 1178 0.38727801437581 1920 1225414 SGTC_1312 1218-2183 165 µM 0.285880011644814 0.358892324785719 no 1179 0.387485011763768 1866 6744073 SGTC_1889 st059080 5.18 µM 0.285477913302605 0.359052616484623 no 1180 0.387639011658194 1946 176925 Isolated from Daphnopsis sellowiana. SGTC_2325 6158266 200 µM 0.284868272164386 0.359295689969974 no 1181 0.387872532210625 1787 3623240 SGTC_315 k915-0449 187 µM 0.284086349147015 0.359607538311665 no 1182 0.38817210399384 1861 20970215 YNL149C PGA2 SGTC_1435 4092-0789 56.7 µM 0.28390691355116 0.359679114429004 no 1183 0.388240859083714 1897 2248285 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.282799881055275 0.360120813890925 no 1184 0.388665122757097 1837 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1339 1486-1321 22.7 µM 0.282422672353415 0.360271360647673 no 1185 0.388809716135272 1788 3469382 SGTC_1970 st070122 35.8 µM 0.28170933271221 0.360556118944744 no 1186 0.389083198870486 1887 102928 SGTC_1343 1487-0095 224 µM 0.281521544889139 0.360631094898068 no 1187 0.389155202790527 1934 4560101 YGL055W OLE1 SGTC_202 3594-0513 34.79 µM 0.281044405658824 0.360821621061966 no 1188 0.389338170509407 1891 708429 SGTC_297 0986-0032 24 µM 0.280173652541079 0.361169409958767 no 1189 0.389672139856587 1807 2847425 SGTC_507 nimesulide 162 µM 0.27843358506418 0.361864756742618 no 1190 0.390339770616455 1941 4495 A COX2 inhibitor. SGTC_1887 st057648 70.8 µM 0.27754658858866 0.362219384321904 no 1191 0.390680218890122 1944 688672 SGTC_453 enantio-paf c16 10 µM 0.277086799687852 0.362403257806703 no 1192 0.390856728735696 1850 13871343 A lipid and platelet activating factor SGTC_2400 5203494 178.7 µM 0.276328126352577 0.362706727107104 no 1193 0.39114802744439 1778 6777674 SGTC_2140 5586273 200 µM 0.276057661226899 0.362814934012371 no 1194 0.391251889473091 1824 854421 SGTC_3018 9082602 49.47 µM 0.275665665500501 0.362971781972146 no 1195 0.391402434552441 1835 17332089 SGTC_560 2332-1943 155 µM 0.275215434350908 0.363151959843793 no 1196 0.391575364887757 1825 21177716 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.274932883453477 0.363265049276097 no 1197 0.391683901468898 1986 551469 SGTC_715 0868-0130 184 µM 0.274324352730259 0.363508650799766 no 1198 0.391917685656556 1972 2876258 SGTC_1777 st045864 34.765 µM 0.274205439468725 0.363556259533076 no 1199 0.391963374090636 1826 4691462 SGTC_1085 doxorubicin 7.67 µM 0.27402446621993 0.363628718970038 no 1200 0.392032909852922 1917 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.273468811829095 0.363851226547356 no 1201 0.392246431740526 1864 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1974 st069448 26.9 µM 0.273349578770372 0.363898978505772 no 1202 0.392292253781836 1942 6323587 YNR016C ACC1 SGTC_2642 cholecalciferol 100 µM 0.272924817964279 0.364069109240824 no 1203 0.392455504259899 1896 9821465 A vitamin D precursor, similar to steriods. SGTC_1870 st057514 26.5 µM 0.272091943246986 0.364402780829737 no 1204 0.392775662144257 1797 5393161 SGTC_74 000s-0487 160.283 µM 0.271383029724284 0.364686871280124 no 1205 0.393048226393926 1967 677548 SGTC_1466 k213-0079 57.5 µM 0.270802740459033 0.364919472090967 no 1206 0.393271376014338 1829 3657981 SGTC_1072 oxiconazole 14.9 nM 0.270515094935341 0.365034789200606 no 1207 0.393382002799502 1848 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1047 2043-3044 82 µM 0.270078910312161 0.365209678933458 no 1208 0.393549773274666 1770 669592 SGTC_3299 9121982 43.1275 µM 0.269687132013394 0.365366787699428 no 1209 0.39370048051569 1804 17594604 YPL160W CDC60 SGTC_299 1273-0059 1.44 µM 0.269134984483861 0.365588245203571 no 1210 0.393912904790299 1921 2848077 SGTC_922 1866-0035 480 µM 0.268898934298885 0.365682934818593 no 1211 0.394003728541913 1833 3156169 SGTC_1504 k297-0033 30 µM 0.268189521690981 0.365967559167048 no 1212 0.394276720069699 1764 4388117 SGTC_1694 st024011 44.9 µM 0.267371570659948 0.366295821926374 no 1213 0.394591543109013 1855 2787533 SGTC_1045 1348-1485 165 µM 0.267131657962598 0.366392123039955 no 1214 0.394683896723789 1879 6810614 SGTC_336 4111-0029 111 µM 0.266727109787831 0.36655452799477 no 1215 0.394839639634411 1802 3131175 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.264368006597607 0.367502059805556 no 1216 0.395748180910545 1848 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1082 camptothecin 424.86 nM 0.264036228342797 0.367635383139353 no 1217 0.395876001408717 1595 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1975 st070967 30.8 µM 0.260826299343355 0.368926097717965 no 1218 0.397113231150666 1981 261391 SGTC_435 c-PAF 6.7 µM 0.260255249034914 0.369155872866715 no 1219 0.397333444758117 1985 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1472 k841-0093 193 µM 0.257766948019411 0.370157642491741 no 1220 0.398293387160377 1944 X1472 SGTC_3285 9112818 20.8695 µM 0.257727199335517 0.370173652157052 no 1221 0.398308726510355 1864 17017947 YPR165W RHO1 SGTC_874 0599-0792 117 µM 0.255751849487615 0.370969551005249 no 1222 0.399071228046471 2003 765305 SGTC_2991 9074669 71.4286 µM 0.255617854859459 0.371023559543368 no 1223 0.399122965078143 1918 17333109 SGTC_2647 atorvastatin 60.16 µM 0.254803888682241 0.371351695337315 no 1224 0.399437285827801 1931 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2307 7538926 6.34 µM 0.253838851410556 0.371740853884565 no 1225 0.399810028567196 1828 96582 SGTC_2591 skatole 100 µM 0.253687096854825 0.371802061990674 no 1226 0.39986865162477 1855 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2226 7298446 200 µM 0.253380804546349 0.371925610636371 no 1227 0.399986979767253 1956 3283010 SGTC_961 1252-1571 372 µM 0.253166136552175 0.372012208788794 no 1228 0.40006991669075 1964 6813498 SGTC_390 dec-rvkr-cmk 16.7 µM 0.252909814666657 0.372115618811878 no 1229 0.400168952488246 1891 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1545 lovastatin 49.4 µM 0.252718585304415 0.372192774037121 no 1230 0.400242842489114 1886 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_888 0916-0002 6.97 µM 0.251596703583639 0.372645522413957 no 1231 0.400676403419638 1932 2802138 YIL048W NEO1 SGTC_2030 5175110 200 µM 0.250964618409564 0.372900685278793 no 1232 0.400920732161223 1907 2831986 SGTC_598 3937-0236 20.2 µM 0.250765144361984 0.372981221403966 no 1233 0.400997845711263 1919 1379313 SGTC_1073 triclabendazole 3.09 µM 0.250757722332436 0.372984218098921 no 1234 0.401000715026369 1867 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.249878209628062 0.373339381708585 no 1235 0.401340767487655 1823 229346 A bile salt which induces apoptosis. SGTC_2939 9044578 71.43 µM 0.246418632185036 0.374737465271633 no 1236 0.40267909222356 1832 2653634 SGTC_600 1495-0418 41.6 µM 0.246296623777799 0.37478680147021 no 1237 0.402726311649758 1874 5377768 SGTC_997 3996-0078 137 µM 0.245163353660332 0.375245156565614 no 1238 0.403164975079644 1878 735687 SGTC_227 fluconazole 33.516 µM 0.245030258817572 0.375298998818448 no 1239 0.403216501115031 1836 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1208 2323-2347 50.3 µM 0.24457136042706 0.375484660421238 no 1240 0.403394170876496 2011 5412760 SGTC_1990 st072050 59.8 µM 0.243813077082518 0.375791510695466 no 1241 0.403687795936013 1816 17233948 SGTC_3326 9140064 16.379 µM 0.243486617105302 0.375923641631529 no 1242 0.403814225607704 1814 1868434 SGTC_1744 st037937 38.9 µM 0.240000158508509 0.377335650263394 no 1243 0.405165066861674 1934 1016152 SGTC_862 0452-0056 10.2 µM 0.236769665576149 0.378645459073582 no 1244 0.406417742920156 1970 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1112 tnp00069 1.16933 µM 0.235415688372753 0.379194847232884 no 1245 0.406943055321317 1979 145826 SGTC_879 0831-1030 162 µM 0.234147469554406 0.379709659591415 no 1246 0.407435247328245 1851 1549252 SGTC_1205 4161-2785 76 µM 0.233722972646265 0.379882024748265 no 1247 0.407600026024374 1784 3498106 SGTC_1669 st015249 58.4 µM 0.232850587993618 0.380236327697487 no 1248 0.407938714426847 2042 722793 SGTC_1385 3091-4834 14.1 µM 0.230260100176458 0.38128899790879 no 1249 0.408944831528223 1965 4072814 SGTC_402 epigallocatechin gallate 10 µM 0.230167184244648 0.381326771585404 no 1250 0.408980930249074 1859 65064 An antioxidant. SGTC_1959 st077091 55.8 µM 0.228601221879027 0.381963561572554 no 1251 0.409589437396162 1875 821356 YKL052C ASK1 SGTC_1872 amphotericin b 148 nM 0.227869773358985 0.382261110664702 no 1252 0.409873740963559 1990 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.2276075141456 0.382367813165214 no 1253 0.409975688914472 2034 1273210 SGTC_32 0928-0142 34.1 µM 0.227359635176834 0.382468673146495 no 1254 0.410072052431303 1990 2244242 SGTC_2372 9071633 200 µM 0.227182021244769 0.382540947747022 no 1255 0.410141103594446 2047 21321366 SGTC_1432 4049-0298 68.4 µM 0.226369095940789 0.382871795215191 no 1256 0.410457180985498 2029 741646 SGTC_2099 5377090 177.372 µM 0.226315610792697 0.38289356580612 no 1257 0.410477978844437 1880 2243829 SGTC_2222 6885208 172.143 µM 0.225991087128394 0.383025667825937 no 1258 0.41060417623248 1950 609514 SGTC_2105 5350118 200 µM 0.22509488805208 0.383390549159996 no 1259 0.410952728844927 1868 2133313 SGTC_1572 epiandrosterone 68.9 µM 0.224344175858521 0.383696276145733 no 1260 0.411244752368102 1933 441302 A steroid. SGTC_355 1311-2252 105 µM 0.223715070874352 0.383952534463467 no 1261 0.411489509143584 1873 5338538 SGTC_56 0957-0365 83.25 µM 0.222953619054451 0.384262770544382 no 1262 0.411785802262032 2004 6752360 SGTC_1131 3454-3128 32.3 µM 0.222095825353638 0.38461234773653 no 1263 0.412119643799038 1957 710982 SGTC_2319 6033012 152.6 µM 0.221915511126517 0.384685843250149 no 1264 0.412189827720254 1862 847246 SGTC_1931 st074438 57.1 µM 0.220846162734271 0.385121791387603 no 1265 0.412606109108957 2029 2787313 SGTC_709 3807-1509 243 µM 0.21948790886155 0.385675728816229 no 1266 0.413134998790451 1968 1886677 YPL242C IQG1 SGTC_2912 7964298 10.93 µM 0.218578979268279 0.386046548417022 no 1267 0.413489014484366 1877 2975850 SGTC_964 1287-0107 19.4 µM 0.218260597207753 0.386176464649369 no 1268 0.413613036608564 2006 51516812 YPR165W RHO1 SGTC_3227 9130768 49.47 µM 0.217900019428145 0.386323614314773 no 1269 0.413753506004069 1960 17720899 SGTC_110 0850-0284 111.64 µM 0.217339200910536 0.386552513530268 no 1270 0.413972004616068 2028 3906265 SGTC_799 1310-0557 151 µM 0.216998789582169 0.386691472363937 no 1271 0.414104644120032 1936 5354492 SGTC_2780 5215298 71.43 µM 0.216982700875454 0.386698040272167 no 1272 0.414110913243548 2076 2834131 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.215649528236302 0.387242395213681 no 1273 0.414630473030264 1967 165521 SGTC_209 4077-0173 175.592 µM 0.215483482712712 0.387310209715755 no 1274 0.414695194242032 1952 15993494 SGTC_3268 9137683 49.47 µM 0.215217915599435 0.387418676888036 no 1275 0.414798711784586 1895 1953228 SGTC_848 0368-0089 85.6 µM 0.214612281978204 0.38766607233197 no 1276 0.415034808709661 2028 762535 SGTC_15 0266-0086 27.098 µM 0.214371476981774 0.38776445151037 no 1277 0.415128691354565 2050 1712902 YIL048W NEO1 SGTC_1363 1636-0063 10.4 µM 0.213953078642828 0.387935402325389 no 1278 0.415291823839542 1923 6072185 SGTC_1965 Pectolinarigenin 58.4 µM 0.213885268426013 0.387963110532885 no 1279 0.41531826425252 1908 5320438 An anti-inflammatory. SGTC_2635 hydroquinidine 100 µM 0.213737209950873 0.388023611288652 no 1280 0.415375996225296 1915 442912 An experimental heart treatment. SGTC_1785 bathophenanthroline 24 µM 0.212765628736821 0.388420693408128 no 1281 0.415754887089816 1861 72812 An iron chelator. SGTC_2456 5770359 74.46 µM 0.210856434451603 0.389201314430902 no 1282 0.416499650022831 2025 3118787 SGTC_1571 st070080 73.4 µM 0.210714557758867 0.38925934210247 no 1283 0.416555007100528 1979 4315245 SGTC_2289 7946404 165.07 µM 0.209580684130396 0.389723185888451 no 1284 0.416997478329755 1913 1246120 YPR165W RHO1 SGTC_704 1310-0270 142 µM 0.209185405398445 0.389884923046421 no 1285 0.41715175260053 1880 5718033 SGTC_1745 st081495 74 µM 0.207549019589881 0.390554689568084 no 1286 0.417790556950626 1937 13842402 YBL026W LSM2 SGTC_2816 7982706 58.44 µM 0.207107052479901 0.390735640840499 no 1287 0.417963127212584 1907 2981853 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.206553881758106 0.390962154711966 no 1288 0.418179140237574 1951 2333 A French combination drug. SGTC_824 1304-0008 100 µM 0.206077512587842 0.391157249324388 no 1289 0.418365182059166 1935 768245 SGTC_870 0573-2213 57.6 µM 0.206004036400038 0.39118734356922 no 1290 0.418393879169844 2027 3916321 SGTC_1331 1472-0049 76.2 µM 0.204597127734826 0.391763708155836 no 1291 0.418943449834538 1904 24051409 SGTC_425 3825-7017 13.1 µM 0.20312165210413 0.392368417683697 no 1292 0.419519974274621 1985 3397440 SGTC_276 colchicine 750 µM 0.202652775682992 0.392560636690919 no 1293 0.419703218364137 1970 2833 A microtubule depolymerizer. SGTC_2280 7785178 200 µM 0.200224718481939 0.393556453213764 no 1294 0.420652418015746 1945 2954328 SGTC_2366 9070441 60.58 µM 0.199879203596029 0.393698215636503 no 1295 0.420787527682618 1935 6837235 SGTC_1303 1160-0052 261 µM 0.199355011698784 0.393913314927756 no 1296 0.420992524774761 2055 3562476 SGTC_43 0570-0105 72.5 µM 0.199336937368902 0.393920732208272 no 1297 0.420999593532467 1958 1114046 YDL195W SEC31 SGTC_1623 st003709 20.3 µM 0.199212405228802 0.393971838319805 no 1298 0.421048297968011 1895 16192618 SGTC_2560 caryophyllene 100 µM 0.199126470498405 0.39400710570149 no 1299 0.421081907687419 2004 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2295 7971645 200 µM 0.198548054470386 0.394244508681175 no 1300 0.42130814549825 1997 2978226 YKL099C UTP11 SGTC_3135 9127742 49.47 µM 0.198080096946343 0.394436604232031 no 1301 0.421491198319688 1907 3643468 SGTC_440 fluspirilene 35.1 µM 0.197696732093619 0.394593993809456 no 1302 0.421641173333017 2016 3396 An atypical antipsychotic. SGTC_3212 9128307 49.47 µM 0.196006836836999 0.395287981277325 no 1303 0.422302407386759 1740 27243542 SGTC_1867 st057372 64 µM 0.195037267367686 0.395686303468265 no 1304 0.42268188633373 2063 688837 SGTC_2477 5967686 25.23 µM 0.193113851427396 0.396476810619005 no 1305 0.42343490248506 1943 776118 SGTC_193 1273-0060 1.558 µM 0.19196812165765 0.396947898098524 no 1306 0.423883588105286 2067 2847393 YHR072W ERG7 SGTC_1275 0867-0008 21.1 µM 0.19188935642728 0.396980289378524 no 1307 0.42391443742833 1982 3422836 SGTC_2417 cerulenin 830 nM 0.191396700637204 0.397182904427934 no 1308 0.424107402397874 2100 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2869 9037858 32.47 µM 0.190760744474909 0.397444495794735 no 1309 0.424356522606418 2086 27187042 SGTC_1619 st003326 88.7 µM 0.190414869621474 0.397586785786729 no 1310 0.4244920232812 2063 2849032 SGTC_2704 st078022 71.1 µM 0.188933591105948 0.398196325183092 no 1311 0.425072432890675 2083 54697681 SGTC_1728 st035614 33.7865 µM 0.188825350502093 0.398240875462109 no 1312 0.425114851208867 1956 15945546 SGTC_3067 9117431 49.47 µM 0.187734636123024 0.398689871782242 no 1313 0.425542338643482 1939 17150885 SGTC_2544 sphondin 68.51 µM 0.187629024501057 0.398733354300525 no 1314 0.425583736025947 2039 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2733 amorolfine 100 µM 0.18646027902176 0.399214635119902 no 1315 0.426041912659988 2118 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_503 tyrphostin 8 294 µM 0.185796357828552 0.399488101294793 no 1316 0.426302230418028 2083 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1923 st058458 19.1 µM 0.18459580742867 0.399982727787603 no 1317 0.426773037308751 2093 3534982 SGTC_42 0133-0086 60.653 µM 0.184355586866968 0.400081717901278 no 1318 0.426867254563049 1987 162923 Model of phenazepam hydroxylation. SGTC_1910 st062352 60.4 µM 0.183770683232965 0.400322771887188 no 1319 0.427096677902233 1982 2245730 SGTC_2605 digitonin 300 nM 0.18286718605768 0.400695201156966 no 1320 0.42745111521646 2116 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1198 1612-1005 86.7 µM 0.182794164958685 0.400725305026952 no 1321 0.427479763581228 2067 6998509 SGTC_3297 9117502 71.43 µM 0.182230941823031 0.400957520675198 no 1322 0.427700745729427 2119 7453720 SGTC_427 1354-0053 47.3 µM 0.18122164966654 0.401373737091846 no 1323 0.428096800983278 2050 6813657 SGTC_225 nsc-122657 1.016 µM 0.181127446710138 0.401412590647035 no 1324 0.42813377076702 2055 275685 SGTC_1316 1272-0050 65.9 µM 0.180834014329654 0.401533621663084 no 1325 0.428248931827386 2009 7340392 SGTC_216 k038-0035 28.382 µM 0.178897807481562 0.402332478354919 no 1326 0.429008972195527 2058 4444231 YPR107C YTH1 SGTC_812 4251-0442 148 µM 0.178641666899312 0.402438189650269 no 1327 0.429109537629289 2093 5723007 SGTC_757 1066-0008 322 µM 0.176467193787318 0.403335898978006 no 1328 0.429963459885653 2061 6842497 SGTC_2254 7938975 95.19 µM 0.176006994485014 0.403525953125009 no 1329 0.430144223713929 2087 2969277 SGTC_1553 gossypol 38.6 µM 0.174683405706113 0.404072698663541 no 1330 0.430664203805159 2076 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2873 9040596 71.43 µM 0.174138286703937 0.404297929943411 no 1331 0.43087839220624 1924 6463863 SGTC_2756 carbadox 75.1 µM 0.173945111861568 0.404377753190919 no 1332 0.430954299433946 1971 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.173722614244039 0.404469698058395 no 1333 0.431041732081318 1963 2724 A muscle relaxant with antifungal properties. SGTC_1506 4226-2149 212 µM 0.173456844791045 0.404579531484432 no 1334 0.431146173255012 2018 991114 SGTC_878 0828-0289 13.7 µM 0.172485182124525 0.404981150373779 no 1335 0.431528054863904 1955 745350 YLR208W SEC13 SGTC_2332 7982454 138.89 µM 0.171362867272516 0.405445163135295 no 1336 0.431969225241332 2091 2981748 SGTC_185 k048-0037 25.491 µM 0.171158612679256 0.405529624999365 no 1337 0.43204952475516 2120 6827589 SGTC_813 k007-0158 173 µM 0.171104695844866 0.405551921028008 no 1338 0.43207072178777 2069 6523916 SGTC_1766 st045414 44.774 µM 0.170972263098145 0.405606686751431 no 1339 0.432122787641227 2051 253960 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.169886532751538 0.406055745039214 no 1340 0.432549686234825 2086 6710655 SGTC_542 3381-0244 89.3 µM 0.169835998926483 0.406076648854699 no 1341 0.432569557564181 2105 1112843 SGTC_2051 5263410 176 µM 0.169371337654597 0.406268873119003 no 1342 0.432752283506702 2136 227584 SGTC_2100 5377183 190 µM 0.169298526553465 0.406298996163841 no 1343 0.43278091744702 2052 2844202 SGTC_1618 st003135 44.5 µM 0.168828567781494 0.406493438493071 no 1344 0.43296574351098 2104 1270615 SGTC_1242 0402-0103 60.1 µM 0.168161318228118 0.406769548176966 no 1345 0.433228185560728 2048 432868 SGTC_2814 7977482 42.97 µM 0.166956182197061 0.407268354121646 no 1346 0.43370226323071 2077 6456762 SGTC_124 0136-0217 7.121 µM 0.165896458548824 0.407707098184176 no 1347 0.434119217272899 2168 3976905 SGTC_2152 5568786 200 µM 0.163334401886751 0.408768311615862 no 1348 0.435127574400686 2072 5399883 SGTC_1490 4089-0339 670 nM 0.16154394289525 0.409510324143165 no 1349 0.435832502196429 2123 742542 SGTC_1398 3558-0053 112 µM 0.159825281243901 0.410222887073502 no 1350 0.436509354260304 2011 4532369 SGTC_2536 dehydroabietamide 32.04 µM 0.159349238605189 0.410420308500414 no 1351 0.436696864759242 2112 3983547 SGTC_699 0375-0592 111 µM 0.158637137862633 0.410715668832606 no 1352 0.436977383749185 2186 762578 SGTC_1415 3966-0071 78.1 µM 0.157898204264777 0.411022212248377 no 1353 0.437268506551612 2112 2893185 SGTC_1348 1493-0373 93.8 µM 0.157335741654755 0.411255583872312 no 1354 0.437490126630542 2067 3010129 SGTC_1111 tnp00062 510.699 nM 0.1565345186497 0.411588073898958 no 1355 0.437805856321702 2142 676306 SGTC_1767 st044992 70.3 µM 0.156484256936716 0.411608933529843 no 1356 0.437825663758964 2015 9600693 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.155921185621852 0.411842636615648 no 1357 0.438047572916612 2056 364106 SGTC_920 mycophenolic acid 780.421 nM 0.155572901743996 0.411987207707362 no 1358 0.438184843052508 1993 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_858 0438-0351 2.77 µM 0.155375081449452 0.412069327354452 no 1359 0.438262813852649 2013 2799119 SGTC_467 ro 31-8220 72.8 µM 0.155366129367566 0.41207304365579 no 1360 0.438266342369307 2129 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3197 9113331 49.47 µM 0.153165005175021 0.412987040665278 no 1361 0.439134076912913 2089 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2014 4013930 200 µM 0.150884270557593 0.413934592951155 no 1362 0.440033504350562 2176 64556 SGTC_490 phenamil 164 µM 0.150132796866311 0.41424690970979 no 1363 0.440329922532687 2141 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1413 3910-0535 34.4 µM 0.149761395524103 0.414401286266831 no 1364 0.440476433847278 2124 2876951 SGTC_2010 4012422 159 µM 0.149732758109515 0.414413190234398 no 1365 0.440487731143656 2079 952393 SGTC_2273 7815444 169.05 µM 0.148860481407715 0.414775814825922 no 1366 0.440831862483926 2170 2824616 SGTC_1782 st039423 80.636 µM 0.148535525294191 0.414910924808805 no 1367 0.440960075882527 1956 2068169 SGTC_1065 prochlorperazine maleate 2.48 µM 0.147965854476229 0.415147806347921 no 1368 0.4411848578731 2143 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3037 9091026 49.47 µM 0.146986154418302 0.415555259080199 no 1369 0.441571474395358 2142 25236398 YIL048W NEO1 SGTC_83 0170-0301 39.027 µM 0.146019409942866 0.415957412670138 no 1370 0.441953032869013 2163 3089716 SGTC_346 4513-0042 7.16 µM 0.145461827714638 0.416189399942032 no 1371 0.442173126109545 2057 2827372 SGTC_2532 xanthone 78.9 µM 0.144981421582751 0.416389300803532 no 1372 0.442362770113545 2113 7020 An insecticide. SGTC_1079 idarubicin 2.36 µM 0.142917574881237 0.417248329455132 no 1373 0.443177639155242 2180 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1226 3909-7979 35.4 µM 0.141630119243315 0.417784403616038 no 1374 0.443686087512481 2129 6615510 SGTC_1924 st058459 75.1 µM 0.141199803934393 0.417963613557309 no 1375 0.443856050480831 2152 688683 SGTC_404 fumagillin 50 µM 0.140813670335375 0.418124438001637 no 1376 0.444008571654749 2047 12015870 A methionine aminopeptidase binder. SGTC_2154 5570129 200 µM 0.140602362719972 0.418212453312026 no 1377 0.444092040800926 2142 673366 SGTC_1001 4048-4355 44.4 µM 0.140058501988727 0.4184390047743 no 1378 0.444306883976262 2093 21824233 SGTC_3198 9112019 49.47 µM 0.137833704558908 0.4193660507803 no 1379 0.445185923096784 2101 45595555 SGTC_1354 1498-1681 81 µM 0.137668110822025 0.419435069642282 no 1380 0.44525136162686 2056 5754243 SGTC_1997 st073024 93.8 µM 0.136938585019273 0.419739162807464 no 1381 0.445539669835892 2167 686268 SGTC_2493 resveratrol 26.09 µM 0.136540206110104 0.419905242023381 no 1382 0.44569712113755 2077 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1816 st051957 91.6 µM 0.136414608134117 0.419957605217559 no 1383 0.44574676300423 2104 674121 SGTC_2597 laccaic acid a 100 µM 0.136227196141262 0.420035741997822 no 1384 0.445820838081379 2067 5491415 A textile dye. SGTC_2346 9031566 143.75 µM 0.132578726534394 0.421557505166559 no 1385 0.447263278822745 2138 4771086 SGTC_1458 k015-0034 6.33 µM 0.132296411998848 0.42167530666972 no 1386 0.447374922621208 1995 3598957 SGTC_1493 4348-0038 111 µM 0.131971472245641 0.421810903091709 no 1387 0.447503428103033 2166 800424 SGTC_2502 avocadyne acetate 18.59 µM 0.131854414636477 0.421859753166681 no 1388 0.447549722787748 2192 3952079 SGTC_3086 9117350 49.47 µM 0.131039781368655 0.422199746352991 no 1389 0.447871918867542 2179 2679265 SGTC_2081 5214970 32.255 µM 0.130618977786233 0.422375394551503 no 1390 0.448038364624285 2170 2063512 SGTC_1648 st011736 69.8 µM 0.130420748579097 0.422458143027125 no 1391 0.448116775898503 2150 2855514 SGTC_584 0986-0246 15.4 µM 0.130320760553084 0.42249988316369 no 1392 0.448156327794745 2196 53315 YDR232W HEM1 SGTC_2744 captopril 92.04 µM 0.129048310921871 0.423031144834759 no 1393 0.448659710902666 2184 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1062 mesoridazine 14.2 µM 0.12900867093675 0.423047697216642 no 1394 0.448675393876035 2169 4078 A neuroleptic. SGTC_1443 4112-3303 14 µM 0.12878002402262 0.423143175459101 no 1395 0.448765856207958 2118 704433 SGTC_3017 9080681 49.47 µM 0.1286476873905 0.423198438574009 no 1396 0.448818215360585 2060 16451914 SGTC_524 r073-0010 27.8 µM 0.127730029901111 0.423581689257669 no 1397 0.449181312157288 2010 2772106 SGTC_1236 0330-0013 258 µM 0.127463623834354 0.423692964706556 no 1398 0.449286731137763 2058 4617066 SGTC_1104 tacrolimus 29.8 µM 0.125211553140077 0.424633876938583 no 1399 0.450178035572094 2171 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1137 ixabepilone 100 µM 0.122942396673354 0.425582362112178 no 1400 0.451076356287418 2155 154225 A novel microtubule stabilizer. SGTC_2091 4-phenylthiadiazole 200 µM 0.122505235447151 0.425765140883104 no 1401 0.451249449968516 2106 270010 SGTC_889 0919-1524 82.7 µM 0.122058208339547 0.425952061112282 no 1402 0.451426459624563 2039 3905452 SGTC_551 k048-0028 34.9 µM 0.122056485164506 0.425952781674125 no 1403 0.451427141970174 2164 6836383 SGTC_2837 9008476 45.46 µM 0.121521676078806 0.426176429055421 no 1404 0.451638923452433 2115 2992805 SGTC_1228 0124-0032 52.5 µM 0.12143218735014 0.42621385392648 no 1405 0.451674361846999 2148 X1228 SGTC_3154 9100113 49.47 µM 0.121074040075257 0.426363640505382 no 1406 0.451816195453723 2077 25237525 SGTC_2812 7970281 58.44 µM 0.120650291902797 0.426540876816714 no 1407 0.451984016292373 2170 2233435 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.119498366552649 0.427022754361678 no 1408 0.452440267033358 2114 6708514 SGTC_232 clozapine 119 µM 0.118941496704931 0.427255745254304 no 1409 0.452660852738332 2183 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1573 oleylamine 1.06 µM 0.117810224806273 0.427729140460281 no 1410 0.453109013873638 2120 5356789 An amine of the fatty acid oleic acid. SGTC_2934 9036370 36.88 µM 0.117360781928947 0.427917244505866 no 1411 0.453287080368746 2151 6462800 SGTC_1853 st056710 91.2 µM 0.116425005386959 0.428308944911084 no 1412 0.453657859357442 2239 269167 SGTC_2425 5628681 7.85 µM 0.116201586511943 0.428402474775327 no 1413 0.453746389708779 2146 5714958 SGTC_679 0422-0091 41.4 µM 0.115583183134763 0.428661377994413 no 1414 0.453991445740932 2139 627384 YHR062C RPP1 SGTC_3184 9108758 49.47 µM 0.115537582315827 0.428680470631586 no 1415 0.454009516769804 2182 902885 SGTC_406 estrone 100 µM 0.114463713219534 0.429130137747818 no 1416 0.45443510497669 2218 5870 A steroid. SGTC_1447 4239-0816 81.9 µM 0.113355209171898 0.429594404229889 no 1417 0.454874474331427 2034 1341554 SGTC_1638 st008370 60.6 µM 0.112237848954968 0.430062478435211 no 1418 0.455317409813197 2207 24207134 SGTC_1739 st037196 92.5 µM 0.11208088477864 0.430128240305845 no 1419 0.455379636826756 2201 612214 SGTC_1561 5-methoxyflavone 52.9 µM 0.111682079030484 0.430295333081154 no 1420 0.455537744642568 2213 94525 SGTC_2213 7173844 200 µM 0.109439278209965 0.431235259854154 no 1421 0.456427040659961 2192 892728 SGTC_2963 9082507 9 µM 0.10819768816222 0.431755760917345 no 1422 0.456919439385435 2162 16459611 SGTC_931 2812-0076 566 µM 0.107857241163712 0.431898504309439 no 1423 0.457054467896755 2181 3450959 SGTC_1185 1319-0113 81.3 µM 0.10714973406511 0.43219517791479 no 1424 0.457335096082031 2138 4672763 SGTC_2002 4023503 131 µM 0.107123465604955 0.432206193606911 no 1425 0.457345515709948 2253 4736863 YCR052W RSC6 SGTC_2600 tangeritin 87.95 µM 0.106711142308238 0.432379108491736 no 1426 0.457509071400486 2174 68077 A bioactive flavone. SGTC_633 0437-0093 97.7 µM 0.106298447722297 0.432552192053072 no 1427 0.457672781576028 2192 2831118 SGTC_1333 1482-0047 286 µM 0.106129940417687 0.432622867516075 no 1428 0.457739628135629 2245 3811116 SGTC_2556 citropten 84.59 µM 0.106029104493199 0.432665161227976 no 1429 0.457779630146303 2209 2775 A potential DNA crosslinker. SGTC_1077 5-fluorocytosine 377 nM 0.105419983968527 0.432920661642318 no 1430 0.458021279751831 2148 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.105419602625673 0.432920821608386 no 1431 0.458021431042606 2190 6728940 SGTC_2180 6301957 200 µM 0.104035222761397 0.433501614851832 no 1432 0.458570698249776 2213 845462 SGTC_3142 9086498 49.47 µM 0.103744885804324 0.433623439091269 no 1433 0.458685902548289 2239 25236367 SGTC_3084 9116877 49.47 µM 0.103619291331626 0.433676139990198 no 1434 0.458735738902616 2239 27241325 SGTC_1017 4239-0030 168 µM 0.103501325993724 0.433725640689493 no 1435 0.458782548578546 2035 1149593 SGTC_16 erodoxin 22.806 µM 0.102861310225838 0.433994222662026 no 1436 0.459036522368129 2199 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_471 1-acyl-paf 4 µM 0.102023728858814 0.434345758859999 no 1437 0.459368920225359 2171 16759367 SGTC_3167 9103034 49.47 µM 0.101326993443382 0.434638221029037 no 1438 0.459645444398086 2214 5127859 SGTC_587 k089-0003 57 µM 0.101141490746349 0.43471609381352 no 1439 0.459719071022177 2235 9659696 SGTC_577 r071-0003 38.6 µM 0.100351816769232 0.435047621941047 no 1440 0.460032510619672 2208 4568517 YMR134W ERG29 SGTC_3335 9143315 29.6265 µM 0.0999936779742144 0.435197994101036 no 1441 0.460174672268005 2118 4899691 SGTC_2007 4011539 71.82 µM 0.0998456827476353 0.435260135769923 no 1442 0.460233419821824 2169 45595301 SGTC_2533 agelasine 13.65 µM 0.099577235940959 0.435372857894062 no 1443 0.460339983535595 2235 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_905 2-aminofluorene 215 µM 0.0979816162073014 0.436042974478415 no 1444 0.460973445629344 2245 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1310 1188-0297 994 nM 0.0971954323914877 0.436373217800636 no 1445 0.461285597648083 2169 1588352 SGTC_1666 st014829 29 µM 0.0969231994165704 0.436487581970763 no 1446 0.461393692536026 2211 3858230 SGTC_2961 9083290 32.55 µM 0.0955395600135584 0.437068926166754 no 1447 0.461943134803079 2247 17741490 SGTC_2683 piperine 63.03 µM 0.0928727721329658 0.438189775063385 no 1448 0.46300231846318 2176 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3221 9128209 49.47 µM 0.0928331897365495 0.438206415272117 no 1449 0.463018041628346 2163 16460723 SGTC_3104 9120930 49.47 µM 0.0925354623641203 0.438331581623575 no 1450 0.46313630859297 2151 17014836 SGTC_2786 7743617 45.45 µM 0.0907769339201454 0.439071002815744 no 1451 0.463834919214735 2129 583674 SGTC_217 ketoconazole 989 nM 0.0907765236022838 0.439071175369983 no 1452 0.463835082234817 2222 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2797 7859098 81.82 µM 0.0878455070890936 0.440304072586481 no 1453 0.464999734058617 2200 972681 SGTC_2614 arthonioic acid 13.39 µM 0.0876483783280415 0.440387013367148 no 1454 0.465078074881082 2255 6710684 SGTC_1287 0971-0001 34.6 µM 0.0876322733207188 0.440393789571015 no 1455 0.465084475222214 2210 4665869 SGTC_1266 0828-0227 32.9 µM 0.0873723539299724 0.440503153423236 no 1456 0.465187771845164 2191 3913820 SGTC_1857 st056007 79.3 µM 0.0868215332929972 0.44073493206387 no 1457 0.465406685580334 2251 619834 SGTC_1162 k048-0130 20.1 µM 0.0845285013820686 0.441700029387958 no 1458 0.466318121550015 2121 6797406 SGTC_3101 9120531 49.47 µM 0.0839514351758288 0.441942961289285 no 1459 0.466547522252968 2257 24824904 SGTC_180 1486-1293 102.781 µM 0.0837264975754218 0.442037660883045 no 1460 0.466636944545723 2281 4140536 SGTC_2781 5567276 71.43 µM 0.0833585680680369 0.442192567757423 no 1461 0.466783215850267 2227 2853274 SGTC_327 1273-0057 3.96 µM 0.0826903589763103 0.442473921905783 no 1462 0.467048875520309 2257 3108138 SGTC_2310 7668677 200 µM 0.0821117952911237 0.442717553667897 no 1463 0.467278906757026 2218 2197143 SGTC_2202 7226349 200 µM 0.0818081450303527 0.442845428728951 no 1464 0.467399639495022 2250 844334 SGTC_1187 1391-0724 117 µM 0.0814078756458911 0.4430140017232 no 1465 0.467558793020926 2154 6997986 SGTC_1440 4100-1550 40 µM 0.0799868147525963 0.443612563011909 no 1466 0.468123871335859 2243 742806 SGTC_2966 9084041 48.03 µM 0.0789733736616146 0.444039510528307 no 1467 0.468526900820217 2229 17741380 SGTC_1909 st060837 51.5 µM 0.0782435629194198 0.444347009095512 no 1468 0.468817155006168 2184 678937 SGTC_2576 guaiol 23.12 µM 0.0774726203649327 0.444671874530425 no 1469 0.469123785789592 2256 227829 SGTC_1668 st014914 51.6 µM 0.0761387659370582 0.445234031567357 no 1470 0.469654349439503 2248 2839556 SGTC_1515 3460-0031 42.1 µM 0.0753057377165989 0.44558516981141 no 1471 0.469985728205079 2231 2876596 SGTC_1461 k072-0203 53.8 µM 0.0744414997331758 0.445949508717134 no 1472 0.47032954418808 2265 5418714 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0743825247644452 0.445974372605036 no 1473 0.470353006748755 2235 107982 A Capsaicinoid. SGTC_2018 5133068 143 µM 0.0739589015016691 0.446152978705887 no 1474 0.47052154375395 2267 785362 SGTC_1389 3405-0187 19 µM 0.072924598091754 0.446589102807627 no 1475 0.470933059803689 2184 799890 SGTC_2795 7780010 54.55 µM 0.0714274326800942 0.447220511494362 no 1476 0.471528788621016 2218 953673 SGTC_978 1416-0512 87.4 µM 0.0714062391231981 0.447229450546334 no 1477 0.471537222092597 2199 6814003 SGTC_344 k064-0035 6.43 µM 0.0700839997370939 0.447787199593475 no 1478 0.472063400872701 2177 5088750 SGTC_2818 7996756 12.99 µM 0.0690579931021999 0.44822006248808 no 1479 0.472471728905711 2266 2241621 SGTC_983 1491-0821 12.2 µM 0.0688964248672078 0.448288232293693 no 1480 0.47253603215088 2276 46495113 SGTC_838 0109-0203 71.4 µM 0.0686550831435152 0.448390063435295 no 1481 0.472632086126739 2288 759422 SGTC_1829 berberine 14.4 µM 0.0683937421293695 0.448500336863818 no 1482 0.472736101612387 2286 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1053 3366-3204 134 µM 0.0679475990446709 0.44868859713164 no 1483 0.47291367386031 2211 3632071 YPR165W RHO1 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.067883572703066 0.448715615458387 no 1484 0.47293915783445 2294 4000243 SGTC_1291 0993-0025 5.79 µM 0.0668830096688728 0.449137871545062 no 1485 0.47333741953411 2269 4353356 SGTC_1957 st077035 62.4 µM 0.0666714109489187 0.449227177510521 no 1486 0.473421647206472 2301 705593 SGTC_2884 9058502 51.95 µM 0.0664342783836703 0.449327263179213 no 1487 0.473516040134529 2224 6471554 SGTC_2999 9069765 71.4286 µM 0.0657573938201644 0.449612971069547 no 1488 0.473785488792725 2265 2097066 SGTC_2128 5255449 168.493 µM 0.0656227346561857 0.449669812811333 no 1489 0.473839094243072 2273 736008 SGTC_1378 2093-0007 380 nM 0.0639523189970125 0.450375006915809 no 1490 0.47450409648459 2223 3618014 SGTC_1347 1493-0251 600 nM 0.0624236179213801 0.451020511208059 no 1491 0.475112743626321 2292 3986378 SGTC_183 3914-0051 30.55 µM 0.0618895895632505 0.451246038888811 no 1492 0.475325378965508 2288 1596232 SGTC_649 1123-0311 367 µM 0.0614158158176275 0.45144613337721 no 1493 0.475514028467665 2291 693629 YIL048W NEO1 SGTC_3048 9093155 49.47 µM 0.0612264498331827 0.451526114014497 no 1494 0.475589432661369 2316 25236002 SGTC_97 0535-0701 19.132 µM 0.0609777000465291 0.45163117899034 no 1495 0.475688484392547 2296 2832013 YGL099W LSG1 SGTC_724 3910-0327 137 µM 0.0595093491474101 0.452251438263755 no 1496 0.476273209566578 2243 2885483 SGTC_1412 3909-8563 178 µM 0.0576944865925932 0.453018231530725 no 1497 0.476995992722194 2304 23767530 SGTC_3183 9108214 49.47 µM 0.0574251322380288 0.453132050800814 no 1498 0.477103271700348 2292 4974831 SGTC_3269 9137823 49.47 µM 0.0572902678287618 0.453189041000416 no 1499 0.477156986384448 2242 17682936 SGTC_2491 paeonol 100 µM 0.0562464273495831 0.453630173420901 no 1500 0.477572748000612 2213 11092 Increases levels of cortical cytochrome oxidase. SGTC_2731 amoxapine 43.43 µM 0.0558104190948766 0.453814449751594 no 1501 0.477746417322609 2319 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3152 9099253 49.47 µM 0.0550692486439656 0.454127723891483 no 1502 0.478041647490852 2258 25236131 SGTC_2950 9072895 21.46 µM 0.054818989998253 0.454233508392393 no 1503 0.478141335659657 2246 17332245 SGTC_2925 9010536 32.5 µM 0.0541286244152796 0.454525343204999 no 1504 0.478416343343036 2252 2994177 SGTC_1502 4534-4282 27.7 µM 0.0525241666877564 0.455203682207514 no 1505 0.479055519838268 2251 3278949 SGTC_2373 9071805 200 µM 0.051852748395621 0.45548758598142 no 1506 0.479323012453529 2329 10149009 SGTC_2063 5246145 200 µM 0.05159901812839 0.455594879691439 no 1507 0.479424100859775 2273 711240 SGTC_1102 cgs 12066b 26.1 µM 0.0500453455697097 0.456251944154057 no 1508 0.480043126515834 2245 6438352 A 5-HT1B full agonist. SGTC_3133 9127736 49.47 µM 0.0490676779628152 0.456665471515422 no 1509 0.480432680808066 2334 27243420 SGTC_1436 4092-1007 8.32 µM 0.0489332068963374 0.456722352877201 no 1510 0.480486262637159 2313 2881121 SGTC_2402 5553605 200 µM 0.0473285386903007 0.457401196833614 no 1511 0.481125691488595 2286 6758546 SGTC_603 3794-0023 45.9 µM 0.0472845740631941 0.457419797528265 no 1512 0.48114321122242 2323 3802260 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.046121601246593 0.457911865518907 no 1513 0.481606664510968 2307 641818 YHR062C RPP1 SGTC_1235 benzylparaben 21.5 µM 0.0459626040136031 0.457979144218483 no 1514 0.481670028032622 2292 7180 SGTC_1562 morin hydrate 59.1 µM 0.0441601851584677 0.458741910379017 no 1515 0.482388359357058 2283 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2449 5812982 45.77 µM 0.0435464401648635 0.459001676118409 no 1516 0.48263297285773 2340 776185 SGTC_956 1185-0240 191 µM 0.0414043927109714 0.459908427778391 no 1517 0.483486755462507 2306 1416193 SGTC_1726 st035556 14.5795 µM 0.0390190326876593 0.460918421497064 no 1518 0.484437607138744 2308 5919439 SGTC_2830 7992007 71.43 µM 0.0386085990553879 0.46109223025922 no 1519 0.484601223175593 2338 1952075 SGTC_1934 st074720 32.6 µM 0.0378470406228504 0.461414751586402 no 1520 0.484904819112511 2339 17250992 SGTC_1406 3909-7906 11.9 µM 0.0373028304843084 0.461645241091159 no 1521 0.48512177433254 2341 X1406 SGTC_80 0159-0065 512.242 µM 0.0366074183595518 0.461939787963105 no 1522 0.485399014250503 2337 1548079 SGTC_2181 6316240 54.2555 µM 0.0357553519078574 0.462300715358947 no 1523 0.48573871714946 2297 12779990 SGTC_219 mitoxanthrone 164.414 µM 0.0348259979198106 0.462694416419555 no 1524 0.486109244930041 2316 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2356 9061756 188.97 µM 0.0342521809250474 0.462937520065156 no 1525 0.48633802828322 2327 20104043 SGTC_3179 9107801 49.47 µM 0.0340793638309927 0.463010738573367 no 1526 0.486406932101277 2346 4818259 SGTC_3240 9133527 49.47 µM 0.0339839869847904 0.463051148020153 no 1527 0.486444959930348 2337 17617455 SGTC_802 4112-3352 742 µM 0.0338888490465695 0.46309145662579 no 1528 0.486482892626897 2320 704594 SGTC_2697 mebhydrolin 72.4 µM 0.0323614247648886 0.463738656398955 no 1529 0.487091912471095 2333 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_269 exalamide 29 µM 0.0322077210221124 0.463803789047451 no 1530 0.487153199444848 2284 3316 A derivative of salicylamide. SGTC_289 k017-0060 526 µM 0.0312342214969274 0.464216336284633 no 1531 0.487541374206331 2348 5512909 SGTC_3206 9114350 49.47 µM 0.0305222637803994 0.46451807236063 no 1532 0.487825268861121 2363 17087243 SGTC_477 mead ethanolamide 10 µM 0.0285880148426677 0.465337932401404 no 1533 0.488596585474496 2354 16061185 SGTC_1746 st038117 42 µM 0.028274034094784 0.465471031762438 no 1534 0.488721795054416 2320 2898218 SGTC_116 0155-0182 31.788 µM 0.0282269294521976 0.46549100019239 no 1535 0.488740579590577 2301 771486 SGTC_1138 3761-0006 1.03 µM 0.0282015312357944 0.465501766948613 no 1536 0.488750707980828 2346 12061087 SGTC_1021 4476-0760 85.3 µM 0.0277346248584283 0.465699701367818 no 1537 0.488936903837369 2343 746768 SGTC_962 1254-0300 21.5 µM 0.0273030354138055 0.465882671518815 no 1538 0.489109017931132 2341 7340576 SGTC_2627 acetyl isogambogic acid 100 µM 0.0270505905625309 0.465989697575572 no 1539 0.489209691670879 2324 6857789 A caspase activator and apoptosis inducer. SGTC_304 1310-0298 97 µM 0.0269445931145391 0.466034636793147 no 1540 0.489251963126473 2349 1550234 SGTC_2053 5265679 138 µM 0.0254929520146404 0.466650125279112 no 1541 0.489830885069748 2364 764595 SGTC_3011 9081274 71.4286 µM 0.0246586915881608 0.46700388366722 no 1542 0.490163602194907 2332 6625322 SGTC_405 ebelactone b 50 µM 0.0246270798183832 0.467017288783221 no 1543 0.490176209637776 2321 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_169 k015-0017 16.025 µM 0.0226859781155612 0.467840492958079 no 1544 0.490950380400654 2342 1840002 SGTC_2134 5324836 1.464 µM 0.02259073690478 0.467880887487315 no 1545 0.490988366411385 2344 699272 SGTC_2 0422-0095 29 µM 0.0224650379020381 0.467934200545946 no 1546 0.491038500334909 2288 6790840 SGTC_628 1636-0253 16 µM 0.0223693448381398 0.467974787490063 no 1547 0.491076666752926 2357 4456143 SGTC_1324 1418-0026 34.4 µM 0.0211421727078753 0.468495305638008 no 1548 0.491566121723897 2294 1372513 SGTC_885 0865-0106 16.8 µM 0.020096330158979 0.468938953456146 no 1549 0.491983263832141 2360 2793380 SGTC_1201 1889-3372 45.9 µM 0.0191321439926842 0.469347996711362 no 1550 0.492367844460443 2324 5392199 SGTC_273 hydroxyurea 18.1 mM 0.0190654682875065 0.469376284200221 no 1551 0.492394439367429 2379 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2617 dihydrotanshinone i 20.83 µM 0.0187113948725037 0.46952650413735 no 1552 0.492535669026601 2368 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_104 0074-0074 590.992 µM 0.0176773332995705 0.469965242045495 no 1553 0.492948131614806 2379 3943124 SGTC_2911 7942208 15.64 µM 0.0170143028800813 0.470246575828831 no 1554 0.493212602687811 2351 1243384 SGTC_1280 0880-0253 10.1 µM 0.0165584628330276 0.470440004243821 no 1555 0.49339443093428 2362 6836607 SGTC_338 4055-0136 114 µM 0.0165283664170275 0.470452775421335 no 1556 0.493406436024194 2376 2900563 SGTC_25 0118-0223 35.662 µM 0.016196338023902 0.470593671073764 no 1557 0.493538878457531 2371 5333628 SGTC_3047 9092122 49.47 µM 0.0158502110963828 0.47074055333279 no 1558 0.493676945397456 2367 17173831 SGTC_1796 st049173 110.4 µM 0.0148911705066581 0.471147552076818 no 1559 0.494059502028932 2376 94134 SGTC_3153 9100258 49.47 µM 0.0142727521407855 0.471410013180026 no 1560 0.494306189029759 2370 25236848 SGTC_198 3454-2873 16.191 µM 0.0121511475362879 0.47231053076882 no 1561 0.495152512781566 2369 710957 SGTC_528 3492-0019 172 µM 0.0120366927592239 0.472359115300149 no 1562 0.495198170292184 2379 2869262 SGTC_892 0929-0076 29 µM 0.0113695520919798 0.472642315806619 no 1563 0.495464302680608 2389 5751038 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0113197929945514 0.472663439046766 no 1564 0.495484152411018 2384 5106787 A p450 inhibitor. SGTC_654 1124-0271 80.9 µM 0.0102592165223489 0.473113682673303 no 1565 0.495907236560499 2377 5403748 SGTC_1084 voriconazole 435 nM 0.0100562836210266 0.473199837155392 no 1566 0.495988190898245 2390 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2936 9038235 15.59 µM 0.00990870079959294 0.473262493734484 no 1567 0.496047064992043 2391 4749415 SGTC_1314 1222-0010 41.1 µM 0.00884129833675491 0.473715681162434 no 1568 0.496472878231555 2373 3526027 SGTC_3158 9100007 49.47 µM 0.00847064628354477 0.473873057018476 no 1569 0.496620741466558 2387 19297233 SGTC_1353 1498-1206 8.11 µM 0.00789732863430391 0.47411649106569 no 1570 0.496849454454351 2386 6756808 SGTC_3012 9080433 71.4286 µM 0.0068268849162272 0.474571033565979 no 1571 0.497276488118993 2394 17688859 SGTC_207 4185-0010 4.486 µM 0.00518677678004693 0.475267536672137 no 1572 0.497930784721336 2392 3761753 SGTC_2775 cyproheptadine 69.59 µM 0.00516210829576225 0.475278013195377 no 1573 0.497940625890961 2393 2913 A selective serotonin reuptake inhibitor. SGTC_2066 5222451 176 µM 0.0046521687003611 0.475494584596629 no 1574 0.498144059904452 2395 2281147 SGTC_2118 5526350 200 µM 0.00404980951078103 0.475750415931974 no 1575 0.498384364174908 2392 743594 SGTC_1754 st042065 16.137 µM 0.00348139569145728 0.475991839309385 no 1576 0.498611126869421 2395 1126236 YIL048W NEO1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.00288104705758569 0.476246835984087 no 1577 0.498850630106948 2394 16725076 SGTC_3289 9119912 71.43 µM 0.00158037583543928 0.476799326265375 no 1578 0.499369521522764 2402 17014829 SGTC_2242 6630449 61.2675 µM 0.00102661434664276 0.477034562905061 no 1579 0.499590440203399 2396 691249 YDR170C SEC7 SGTC_2008 4012253 172 µM 0.000547879632765527 0.477237934791663 no 1580 0.499781427660854 2403 603940 SGTC_2903 5923464 63.88 µM 0.000278035338656919 0.477352570296295 no 1581 0.499889079949393 2395 2876576 SGTC_277 nystatin 15.5 µM -0.000419652207472414 0.477648971233557 no 1582 0.499832582996289 2406 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1417 3966-0327 90.4 µM -0.000725949867425245 0.477779100609663 no 1583 0.49971038792987 2407 651118 SGTC_2407 paclitaxel 400 µM -0.00126837641851399 0.478009554235974 no 1584 0.499493991154867 2415 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_614 0462-0418 107 µM -0.00159472869154967 0.47814821077677 no 1585 0.499363795568833 2387 5188303 SGTC_367 0335-0881 7.1 µM -0.00163033553119494 0.478163339133297 no 1586 0.499349590513496 2410 23828853 SGTC_1685 st024049 53.0905 µM -0.00173346017228159 0.478207154104549 no 1587 0.499308449792223 2415 1941139 SGTC_380 3970-0968 6 µM -0.00253320964324862 0.478546955704626 no 1588 0.498989396649053 2414 2891601 SGTC_62 0180-0423 3.232 µM -0.00275447198523672 0.478640969532145 no 1589 0.498901126054455 2419 30102 YGL099W LSG1 SGTC_1123 mangostin 811.285 nM -0.00320773431912594 0.478833563293585 no 1590 0.498720301350396 2418 5281650 An antioxidant. SGTC_615 k087-0205 167 µM -0.00351636705331805 0.478964705941011 no 1591 0.498597175399971 2412 9642773 SGTC_2384 9036245 200 µM -0.00370486375213325 0.479044802118051 no 1592 0.498521976587377 2445 6462766 SGTC_2701 st077767 14.721 µM -0.00427577605281257 0.479287399806524 no 1593 0.498294217348601 2423 5721188 SGTC_877 0771-0151 33.1 µM -0.00441441014717502 0.479346310735218 no 1594 0.49823891086899 2428 6166523 SGTC_2244 6635614 200 µM -0.00481049412026275 0.479514624445003 no 1595 0.498080897907418 2416 836499 SGTC_3169 9102970 49.47 µM -0.00534155078334269 0.479740299785192 no 1596 0.497869039683103 2412 17027839 SGTC_1876 myriocin 605 nM -0.00608138885493775 0.480054708700547 no 1597 0.497573891816456 2419 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1612 st002233 45.4 µM -0.00622770321999479 0.480116889378371 no 1598 0.497515521935548 2421 1035021 SGTC_429 1112-0049 25.5 µM -0.00704304977476876 0.480463404169772 no 1599 0.497190252891266 2417 2836170 SGTC_1644 st010134 20.9 µM -0.00729809159440144 0.480571797642424 no 1600 0.497088508542152 2416 3818134 SGTC_357 1325-0123 420 µM -0.00737742270698806 0.480605513876078 no 1601 0.497056860859208 2417 1098503 SGTC_1588 farnesol 29.9 µM -0.00781937727715225 0.480793349946946 no 1602 0.496880551586329 2421 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2977 9011197 71.43 µM -0.0086341167267107 0.481139635274852 no 1603 0.49655552858024 2431 2704722 SGTC_925 2064-1272 59.6 µM -0.00869215907183389 0.481164305318124 no 1604 0.496532373903615 2433 6815817 SGTC_438 sphingosine 6.67 µM -0.00954476603464111 0.481526701603388 no 1605 0.496192247088335 2425 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2436 5633522 8.09 µM -0.00976006952098129 0.4816182176894 no 1606 0.49610635742591 2426 5724242 SGTC_3332 9141069 11.198 µM -0.0103013158847809 0.481848282090448 no 1607 0.495890442232317 2420 17332883 SGTC_1791 st048313 56.1 µM -0.012108998149599 0.482616706312032 no 1608 0.495169326716973 2432 1204976 SGTC_2207 7258803 200 µM -0.0123791033556144 0.482731530436366 no 1609 0.495061578407406 2432 3666799 SGTC_2872 9044037 25.97 µM -0.0144073631956289 0.483593806827258 no 1610 0.494252492509899 2435 6465195 SGTC_1002 4049-0206 172 µM -0.0146811817640117 0.483710221591885 no 1611 0.494143266259399 2444 4662749 SGTC_2297 7971671 152.32 µM -0.0162977014484085 0.48439751762858 no 1612 0.493498445638616 2451 909016 SGTC_2563 tomatine 8.54 µM -0.0167715033212735 0.484598972953407 no 1613 0.493309451877323 2428 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2558 carylophyllene oxide 100 µM -0.0180660103246607 0.485149402929788 no 1614 0.49279309667785 2422 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1196 1588-0294 184 µM -0.020297883583241 0.486098470950371 no 1615 0.491902872048086 2480 6144269 SGTC_613 3914-0030 117 µM -0.0204985744264876 0.486183815425516 no 1616 0.491822824640665 2420 1145395 SGTC_1036 k216-0215 33.5 µM -0.0207578475349465 0.486294073147817 no 1617 0.491719411640469 2439 622330 SGTC_3306 9127676 59.7925 µM -0.0209097023452 0.486358650966487 no 1618 0.49165884348235 2464 41905287 SGTC_2825 7998094 58.44 µM -0.0210714980447272 0.486427456644057 no 1619 0.491594310555433 2460 2987815 SGTC_2054 5233173 129 µM -0.0213208492140499 0.486533497188396 no 1620 0.491494856175411 2479 6889 SGTC_1015 4130-4525 82 µM -0.0214400244215663 0.486584178674592 no 1621 0.49144732301188 2463 1363237 SGTC_3125 9127534 49.47 µM -0.021815049952829 0.486743666706679 no 1622 0.491297744458908 2446 1639235 SGTC_3075 9116269 49.47 µM -0.0228107683244735 0.487167128532604 no 1623 0.490900609189851 2465 17015205 YNL244C SUI1 SGTC_332 4112-0506 40.9 µM -0.0228230049392154 0.487172332644487 no 1624 0.490895728757429 2442 2790355 SGTC_1792 st045773 43.6 µM -0.0231903488872192 0.487328561425227 no 1625 0.49074921850554 2446 2919270 SGTC_845 0330-0138 4.51 µM -0.0232657033425293 0.4873606093828 no 1626 0.490719164536078 2431 9039800 SGTC_937 3122-0005 46.7 µM -0.023674054258151 0.487534280857679 no 1627 0.490556300953403 2448 759535 SGTC_729 4092-0585 94.1 µM -0.0242490641763664 0.487778836337636 no 1628 0.490326971033597 2448 2169061 SGTC_594 1487-1584 10.8 µM -0.0249214198809741 0.488064799439075 no 1629 0.49005882097238 2447 5013332 SGTC_2776 terbinafine 19.92 µM -0.025740514540169 0.488413181125103 no 1630 0.489732154311241 2445 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_445 e6 berbamine 66 µM -0.0265726228522838 0.488767106898586 no 1631 0.489400304672789 2484 6610268 A calcium/calmodulin antagonist. SGTC_3260 9137109 49.47 µM -0.0266659760529696 0.488806813949665 no 1632 0.489363075326492 2444 17478346 SGTC_2159 5658611 73.75 µM -0.0268003870080561 0.488863984789032 no 1633 0.489309472271082 2445 793844 SGTC_506 n9-isopropylolomoucine 153 µM -0.0271969133051932 0.489032646040086 no 1634 0.489151338811286 2453 6610355 SGTC_2028 5153890 36.43 µM -0.0299255866951617 0.490193330526375 no 1635 0.488063199876535 2455 2830968 YPR165W RHO1 SGTC_451 chloral hydrate 100 µM -0.0306710983224121 0.490510460575021 no 1636 0.487765920255889 2500 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_408 cantharidin 100 µM -0.0315106260850599 0.490867590922507 no 1637 0.487431158981836 2504 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_518 1021-0119 62.6 µM -0.0325832747830981 0.491323900207662 no 1638 0.487003453769195 2493 1097762 SGTC_222 nsc-310342 10.666 µM -0.0334765129866258 0.491703896200995 no 1639 0.486647297626695 2456 432556 SGTC_3082 9117008 49.47 µM -0.0334818911360227 0.491706184163928 no 1640 0.486645153257613 2491 41448529 SGTC_1550 gossypolone 36.6 µM -0.0335304355690392 0.49172683586426 no 1641 0.486625797698741 2476 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1626 st003712 1.76 µM -0.033632815210256 0.491770390131253 no 1642 0.486584977154901 2498 24207035 SGTC_2127 5253358 187.912 µM -0.0338458639864423 0.491861025489129 no 1643 0.486500031352946 2469 20612 SGTC_3214 9129694 49.47 µM -0.0339715613116687 0.491914499929654 no 1644 0.48644991419607 2465 17158655 SGTC_2587 piperic acid 92.2 µM -0.0343747083147342 0.49208600861558 no 1645 0.486289175695288 2484 5370536 SGTC_980 1473-0395 201 µM -0.0344166095210437 0.492103834507464 no 1646 0.486272469417691 2467 768876 SGTC_1807 st050092 58.9 µM -0.0344415827400783 0.492114458789103 no 1647 0.4862625124478 2468 5008496 SGTC_626 0214-0009 33 µM -0.0346473639639063 0.492202003889958 no 1648 0.486180466585365 2496 3437874 SGTC_2321 7390090 138.78 µM -0.0358653691613841 0.492720184992392 no 1649 0.48569485474867 2507 649046 SGTC_2155 5570423 76 µM -0.0360438654506782 0.492796124476628 no 1650 0.485623691044827 2479 797402 SGTC_1565 sinapyl alcohol 95.1 µM -0.0369577373435167 0.493184926283045 no 1651 0.485259351707629 2491 5280507 A phenol propionate derived from cinnamic acid. SGTC_2981 9013952 38.96 µM -0.0374064959796885 0.493375850587421 no 1652 0.485080446627232 2511 2996344 SGTC_272 doxorubicin 8.13 µM -0.038140836941756 0.493688279109072 no 1653 0.48478769590599 2457 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2507 purpurin 79.67 µM -0.0383137559098636 0.493761848798293 no 1654 0.48471876160477 2467 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2158 5657123 3.6195 µM -0.0383379889689988 0.49377215895449 no 1655 0.484709101110521 2470 2858827 SGTC_632 0781-2353 4.65 µM -0.0394891343662093 0.494261927990491 no 1656 0.484250208140412 2515 6811515 YHR007C ERG11 SGTC_733 4069-0007 56.1 µM -0.0397039090632992 0.494353307519323 no 1657 0.48416459257712 2473 5717425 YNL287W SEC21 SGTC_2802 7925815 54.55 µM -0.0402839752968958 0.494600107980243 no 1658 0.483933364634641 2480 1262923 SGTC_1676 st018489 23.4 µM -0.0408057505935743 0.494822109196799 no 1659 0.483725377434175 2529 3696235 SGTC_3162 9099653 49.47 µM -0.0415115982377736 0.495122430736648 no 1660 0.483444023384186 2483 25237511 SGTC_821 1114-0266 29.2 µM -0.0420901068991193 0.495368574608897 no 1661 0.483213433367105 2516 3123235 SGTC_2447 5741742 33.78 µM -0.0430781482213849 0.495788970468964 no 1662 0.482819619159704 2524 1776504 SGTC_2679 rapamycin 1 nM -0.0431393700694767 0.495815019549778 no 1663 0.482795217859819 2501 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_205 1486-1330 71.903 µM -0.0438808619955481 0.496130515870907 no 1664 0.482499685259979 2467 4118834 SGTC_756 0508-1999 28.3 µM -0.0455746125070419 0.496851196073872 no 1665 0.481824652212516 2497 6753853 SGTC_1716 st033144 30.6155 µM -0.0457604325178212 0.496930261989218 no 1666 0.481750598014906 2500 674617 SGTC_1962 st076595 64.5 µM -0.0458161208925304 0.496953957266664 no 1667 0.481728404844635 2496 279619 SGTC_261 5-fluorouridine 15.376 µM -0.0464066425160622 0.49720522352614 no 1668 0.481493071128249 2509 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2967 9089538 49.85 µM -0.0474986122008898 0.497669858194925 no 1669 0.481057918196133 2503 728216 SGTC_791 1348-1292 225 µM -0.048652114359611 0.498160678439841 no 1670 0.480598268926994 2589 5437054 SGTC_3351 9150312 21.596 µM -0.048686372585818 0.498175255512103 no 1671 0.480584618049072 2490 4904905 SGTC_698 k064-0052 127 µM -0.0501703700700015 0.498806707050758 no 1672 0.47999331153355 2476 5088751 SGTC_629 3448-6466 76.7 µM -0.0510873350697819 0.499196883808641 no 1673 0.479627963982626 2509 573744 SGTC_7 0192-1582 4.227 µM -0.0517072291919204 0.499460654725605 no 1674 0.479380988442663 2500 252616 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0520158004662725 0.499591954868684 no 1675 0.479258051752798 2498 688667 SGTC_1273 0849-0096 14.1 µM -0.0522247506223633 0.499680865262114 no 1676 0.479174805847725 2519 5286025 SGTC_1826 st055655 41.6 µM -0.0522958374213691 0.49971111341405 no 1677 0.479146485018499 2535 676168 SGTC_2416 tofa 880 nM -0.0529062951503836 0.499970869402074 no 1678 0.478903284309243 2551 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2480 5767542 37.17 µM -0.0530432159357679 0.499970869402074 no 1679 0.478848737410808 2546 2867358 SGTC_2529 gangaleoidin 93.61 µM -0.0538030285778867 0.499647561390103 no 1680 0.478546048280223 2531 4565183 SGTC_3121 9125696 49.47 µM -0.0541192684102446 0.499512998179047 no 1681 0.478420070386018 2481 1235365 SGTC_1414 3917-0015 5.4 µM -0.0548352707364746 0.499208332257809 no 1682 0.478134850339635 2520 6618702 SGTC_2336 9001819 198.65 µM -0.0548855086307744 0.499186955562712 no 1683 0.478114838456698 2545 2989602 SGTC_2481 5478948 45.16 µM -0.0555299246121166 0.498912750748545 no 1684 0.477858145164946 2580 77792 SGTC_3010 9080089 71.4286 µM -0.0555598408001612 0.498900021152096 no 1685 0.477846228729349 2509 17027233 SGTC_1630 st005209 31.3 µM -0.0558157367100533 0.498791135278927 no 1686 0.477744299202732 2493 3367314 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0575470014215426 0.498054470282062 no 1687 0.477054733198021 2631 61125 An anti-inflammatory. SGTC_1723 st034307 2.5525 µM -0.0584532432047518 0.497668860680005 no 1688 0.476693802645362 2554 867466 SGTC_3085 9117376 49.47 µM -0.0592987550001848 0.497309093893929 no 1689 0.476357076368812 2579 16480349 SGTC_2463 5473429 200 µM -0.0593463472702719 0.497288843359933 no 1690 0.476338123179115 2593 5399405 SGTC_2379 9035213 200 µM -0.0609839597864866 0.496592043050122 no 1691 0.47568599175656 2496 646551 SGTC_1249 0481-0015 10.2 µM -0.0612080518229124 0.496496693171919 no 1692 0.475596758665382 2512 4227577 SGTC_460 trequinsin 123 µM -0.0612916570064588 0.496461119696067 no 1693 0.475563467528013 2503 5537 A vasodilator. SGTC_1939 st074455 53.6 µM -0.0617335353090965 0.496273103752276 no 1694 0.475387516787975 2516 1644229 SGTC_107 0358-0022 2.6945 µM -0.0622073963709217 0.49607148030241 no 1695 0.47519883622383 2595 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_356 1634-0012 32.5 µM -0.0634796761020794 0.495530142283466 no 1696 0.474692271359789 2512 735457 SGTC_2745 rifampicin 24.3 µM -0.0644117437999866 0.49513356510428 no 1697 0.474321189623006 2556 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2586 curcumin 80 µM -0.0646779741753864 0.495020289980122 no 1698 0.474215200078625 2583 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2427 5545055 42.75 µM -0.0650318613181398 0.49486971946735 no 1699 0.474074316137627 2531 5372858 SGTC_1954 st077032 68.9 µM -0.0653903711154827 0.494717182871003 no 1700 0.473931595204782 2602 698907 SGTC_3005 9076496 71.4286 µM -0.065819138923461 0.494534754334266 no 1701 0.473760909309193 2528 21368410 SGTC_1981 st071826 47 µM -0.0662152929078938 0.494366203069076 no 1702 0.473603210757635 2585 11838600 SGTC_2301 7769476 200 µM -0.0674457520142876 0.493842687332217 no 1703 0.473113423621543 2569 977820 SGTC_2376 9072922 81.32 µM -0.0678058360999264 0.493689486574935 no 1704 0.472970098960648 2646 17087968 SGTC_602 3130-1533 38.1 µM -0.0690934786221145 0.493141656170513 no 1705 0.472457605965203 2607 720941 SGTC_1129 3453-1384 223 µM -0.0692931318211481 0.493056714400603 no 1706 0.47237814630572 2726 1084452 SGTC_842 0271-0008 11.1 µM -0.069635969206228 0.492910856145619 no 1707 0.472241703565807 2643 1221709 SGTC_2655 perillic acid 100 µM -0.0701294594444454 0.492700905142887 no 1708 0.472045309586973 2537 5702197 An apoptosis inducer. SGTC_1471 k673-0312 37 µM -0.0703945295282824 0.492588134280391 no 1709 0.471939822626456 2545 24099884 SGTC_1795 st049545 62.3 µM -0.0705993555383705 0.492500993935987 no 1710 0.471858311670259 2533 5291882 SGTC_3057 9095946 49.47 µM -0.0733644885917629 0.491324643700852 no 1711 0.470758037707658 2515 24540043 SGTC_2525 harmine 47.85 µM -0.0736179263615343 0.491216829152459 no 1712 0.470657203335201 2605 5280953 A monoamine oxidase inhibitor SGTC_1516 st013856 110 µM -0.0737030057393002 0.491180635816565 no 1713 0.470623353531131 2676 5281404 A mutagen and neurotoxin. SGTC_250 brefeldin a 552.239 µM -0.074081389961042 0.491019669523611 no 1714 0.470472811612967 2521 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_746 1095-0025 46.6 µM -0.0749832835188921 0.490636006029084 no 1715 0.470114006132406 2574 6749286 SGTC_777 1315-0167 517 µM -0.0760226352182705 0.490193878916831 no 1716 0.469700545003333 2611 4221767 SGTC_3157 9099274 49.47 µM -0.0767824426358605 0.489870674011161 no 1717 0.469398309123316 2558 17217662 SGTC_752 1896-0090 130 µM -0.076935622378079 0.489805515609074 no 1718 0.469337379478919 2548 772567 SGTC_1176 0848-0131 83.3 µM -0.0770182055035664 0.489770387157069 no 1719 0.469304531043636 2598 6769040 SGTC_2257 7960413 200 µM -0.0780207895267618 0.489343923576516 no 1720 0.468905757873934 2588 2974689 YIL048W NEO1 SGTC_2179 6298986 200 µM -0.0789308161500606 0.488956841155913 no 1721 0.468543825977712 2590 738374 SGTC_3019 9081971 49.47 µM -0.080934245648731 0.488104713872108 no 1722 0.467747122599806 2603 16451803 SGTC_1661 st013063 9.66 µM -0.080956864666057 0.488095093530873 no 1723 0.46773812843149 2546 721395 SGTC_343 4130-2827 29.8 µM -0.080958879423198 0.48809423661285 no 1724 0.467737327289402 2580 1118244 SGTC_1191 1487-1166 10.6 µM -0.0830099176331671 0.487221916701986 no 1725 0.466921826850948 2661 3955771 SGTC_1408 3909-7976 48.8 µM -0.0835397770551121 0.486996573806982 no 1726 0.466711175198097 2575 24152374 SGTC_1684 st024538 14.6195 µM -0.0843715473457908 0.486642840220586 no 1727 0.46638051426755 2560 6732859 SGTC_1597 7-benzyloxygramine 47.5 µM -0.0845757045994059 0.486556018232385 no 1728 0.466299357383927 2544 260807 SGTC_2684 capsaicin 100 µM -0.0849944547245244 0.486377938297527 no 1729 0.466132899623417 2643 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3348 9149464 3.537 µM -0.0859158796406717 0.485986097786672 no 1730 0.465766644029894 2536 1951442 SGTC_1365 1672-3266 55.4 µM -0.086299728189424 0.485822868260015 no 1731 0.46561407727241 2566 6415873 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.086544142843348 0.485718933481731 no 1732 0.465516933383215 2556 15053 SGTC_342 k048-0088 23.3 µM -0.0873690006018579 0.48536817853973 no 1733 0.465189104533182 2545 6820570 SGTC_666 0272-0154 136 µM -0.0888709265880059 0.484729542582005 no 1734 0.464592244662248 2589 6870312 SGTC_1373 2887-0003 58.5 µM -0.0894700072567584 0.484474817525498 no 1735 0.464354194354769 2654 776948 SGTC_689 0833-0039 98 µM -0.0899361607021286 0.484276616604687 no 1736 0.464168972745151 2624 5374726 SGTC_3126 9127922 49.47 µM -0.091574092613389 0.483580225525877 no 1737 0.463518218020115 2781 45595682 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0924016759657251 0.483228385085529 no 1738 0.463189453949426 2572 688664 SGTC_1801 st050089 28.441 µM -0.0926425830102479 0.483125967825207 no 1739 0.463093756423677 2555 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1833 st055984 71 µM -0.0928262987285797 0.483047865167806 no 1740 0.463020778923205 2614 676288 SGTC_2471 5466956 24.79 µM -0.093024448877597 0.482963626762054 no 1741 0.462942069020636 2631 724419 SGTC_2892 9047358 58.44 µM -0.09355097202014 0.482739792784996 no 1742 0.462732928694635 2616 6466771 SGTC_485 niflumic acid 177 µM -0.0939550928352461 0.482567997813474 no 1743 0.462572414797545 2692 4488 A COX2 inhibitor. SGTC_2162 5663267 200 µM -0.0943542663984652 0.482398309135375 no 1744 0.462413871896426 2570 6456493 SGTC_1420 4'-methoxyflavone 42 µM -0.0948429105140285 0.482190590870097 no 1745 0.462219801404221 2561 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1916 st067606 49.2 µM -0.0951316040193562 0.48206787209818 no 1746 0.462105147763489 2677 19590279 SGTC_555 4296-0685 37 µM -0.0977765818384578 0.480943616909435 no 1747 0.461054851624758 2560 2908540 YHR072W ERG7 SGTC_650 1328-0195 38 µM -0.0979814202469945 0.480856555981614 no 1748 0.460973523431831 2561 2780821 SGTC_2326 6164455 177.58 µM -0.0981642854723872 0.480778834921814 no 1749 0.460900920759405 2640 2888790 SGTC_2707 st078556 66.6 µM -0.0987670617315056 0.480522649194957 no 1750 0.460661610757872 2626 17250899 SGTC_670 4204-0025 119 µM -0.099205085141157 0.480336490059767 no 1751 0.460487718709825 2692 719039 SGTC_833 3852-0053 558 µM -0.102156147409407 0.47908240787316 no 1752 0.459316367443556 2697 3123681 SGTC_1715 st032160 10.2275 µM -0.103549936273661 0.478490175169985 no 1753 0.458763259525825 2642 5289825 SGTC_371 0195-0006 7.36 µM -0.103938586652637 0.478325042741124 no 1754 0.458609042603863 2566 3928593 SGTC_3318 9139014 38.6185 µM -0.104950885684857 0.47789494774934 no 1755 0.458207390473879 2589 16643984 SGTC_789 1309-1135 70.6 µM -0.105572256928376 0.477630958773581 no 1756 0.457960868737248 2600 3092424 SGTC_31 0508-1974 57.237 µM -0.106488910564135 0.477241537310309 no 1757 0.457597226733974 2607 6810525 SGTC_2204 7233102 200 µM -0.106579092940167 0.477203226348889 no 1758 0.457561452756603 2593 2172480 SGTC_230 MPP+ 141.667 µM -0.106590494575008 0.477198382761267 no 1759 0.457556929925898 2637 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_899 1083-0020 478 µM -0.107842912334141 0.476666357342859 no 1760 0.457060151123776 2778 767123 SGTC_2717 st081029 62.2815 µM -0.109309380344098 0.476043456586781 no 1761 0.45647855337075 2606 5292846 SGTC_924 2046-0044 21.3 µM -0.109951133608253 0.475770882130299 no 1762 0.456224064791614 2602 3623589 SGTC_2640 pentamidine 10.38 µM -0.110168348499408 0.475678626133966 no 1763 0.456137931841257 2665 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2845 9003024 42.97 µM -0.110234420185036 0.475650564277673 no 1764 0.456111732622483 2785 2990173 SGTC_2949 9072542 2.23 µM -0.110247883648524 0.475644846112689 no 1765 0.456106394016755 2683 16457352 SGTC_2764 methyldopa 94.69 µM -0.110661583552237 0.475469143084316 no 1766 0.455942355349433 2681 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1552 6-methylflavone 10.6 µM -0.111090878115727 0.475286821871299 no 1767 0.455772141088582 2606 689013 SGTC_2304 7443016 91.4 µM -0.11149158611711 0.475116646027196 no 1768 0.455613268654796 2576 939854 SGTC_52 0329-0193 875 nM -0.11210792018668 0.474854905270178 no 1769 0.455368918808172 2820 3739292 SGTC_470 aa-861 153 µM -0.112306342404484 0.474770642912879 no 1770 0.455290256554413 2627 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_57 miconazole 162.5 nM -0.112359301497315 0.474748153394193 no 1771 0.455269261814681 2570 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1171 0368-0077 21.4 µM -0.114030036867628 0.474038703424 no 1772 0.454606991379149 2604 3239779 SGTC_1966 st070145 16.1 µM -0.114772987946404 0.473723247923157 no 1773 0.454312530018635 2588 3748532 SGTC_319 1348-1596 45.5 µM -0.115168895945182 0.473555152917567 no 1774 0.454155626017664 2769 5380505 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.115193333455963 0.473544777369307 no 1775 0.454145941316885 2923 5282309 SGTC_128 0906-2981 13.371 µM -0.115255320411373 0.473518459358214 no 1776 0.454121375716397 2680 6740226 SGTC_2517 totarol 10 µM -0.116401372347429 0.473031897159636 no 1777 0.453667223906328 2668 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1649 st011737 51.3 µM -0.117125493052209 0.47272448871491 no 1778 0.453380304118024 2656 1761035 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.118220730996172 0.472259562085212 no 1779 0.452946382091346 2619 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2124 5246320 200 µM -0.118600258521729 0.472098462086688 no 1780 0.452796030263962 2708 579342 SGTC_2691 st077356 60.2 µM -0.120941808938537 0.471104634109271 no 1781 0.451868563229405 2754 2839272 SGTC_3151 9099821 49.47 µM -0.120968572125815 0.471093275995224 no 1782 0.45185796408033 2725 17174189 SGTC_1029 k015-0030 64.7 µM -0.124199543274005 0.469722249352533 no 1783 0.450578641927086 2737 2208316 SGTC_2083 5306046 65.942 µM -0.129661654549321 0.467405287891598 no 1784 0.448417060813993 2674 539837 SGTC_2389 9091542 195.52 µM -0.129731052602677 0.467375857013643 no 1785 0.448389606873426 2701 3626624 YOL127W RPL25 SGTC_385 1494-0393 12.4 µM -0.130945987988894 0.466860646594499 no 1786 0.447909017354048 2678 3090647 SGTC_2217 6934799 96.0675 µM -0.131017825419478 0.46683018465284 no 1787 0.447880603154788 2645 675606 SGTC_383 2324-0395 7.37 µM -0.131192652033747 0.466756051993288 no 1788 0.447811454273432 2762 3146421 SGTC_465 cgp-37157 41 µM -0.131565136807898 0.466598109141695 no 1789 0.447664131279151 2685 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_101 0490-5701 117.494 µM -0.132996516224143 0.465991217663327 no 1790 0.447098067837619 2625 4661669 SGTC_2755 lomerizine 42.69 µM -0.133524501332413 0.465767376807241 no 1791 0.446889294249764 2689 3949 A calcium channel blocker. SGTC_2231 micatex 6.853 µM -0.134196466898162 0.465482510679648 no 1792 0.446623609824983 2670 20737 An antifungal of unknown mechanism. SGTC_5 0352-0601 109.883 µM -0.134451166226257 0.465374540697048 no 1793 0.446522912043931 2653 762456 SGTC_1947 st076332 61.6 µM -0.135070192068004 0.465112139144937 no 1794 0.44627818872787 2720 24208416 SGTC_2437 5741531 144.16 µM -0.136229833925944 0.464620614438569 no 1795 0.445819795477001 2776 2262990 SGTC_636 0kpi-0074 126 µM -0.137282716396387 0.464174387402816 no 1796 0.445403665700663 2713 616434 SGTC_3141 9094609 49.47 µM -0.137373226566875 0.464136029960151 no 1797 0.445367896249629 2649 25236309 YDL196W YDL196W SGTC_562 3772-2733 112 µM -0.137913395106588 0.463907118057164 no 1798 0.445154431904753 2719 2876874 YIL048W NEO1 SGTC_717 1532-0246 73.2 µM -0.138022951912894 0.46386069167491 no 1799 0.445111139073919 2719 9561992 SGTC_1643 st009866 20.2 µM -0.138765041324967 0.46354623285709 no 1800 0.444817909822101 2684 3156273 YOR207C RET1 SGTC_2059 5238311 157 µM -0.140208612166751 0.462934588185337 no 1801 0.444247583798504 2657 703021 SGTC_328 k915-0120 63.5 µM -0.140805741953201 0.462681608296941 no 1802 0.444011703419869 2781 6624543 SGTC_2891 9063876 19.48 µM -0.141434912570525 0.462415070328421 no 1803 0.443763187613938 2706 6472478 SGTC_2866 9034245 58.44 µM -0.141921434436758 0.462208974763027 no 1804 0.443571031727463 2769 6462273 SGTC_3171 9103192 49.47 µM -0.142233330390249 0.462076857827554 no 1805 0.443447852784212 2669 13018434 SGTC_1027 k015-0025 8.67 µM -0.142259900751626 0.46206560300228 no 1806 0.443437359444135 2640 3598955 SGTC_2835 9006588 71.43 µM -0.142798293234012 0.461837554198576 no 1807 0.443224742534818 2889 2345538 SGTC_554 4483-2211 187 µM -0.14294540709999 0.46177524283851 no 1808 0.443166648547584 2753 747107 SGTC_2687 chenodiol 100 µM -0.14308219420975 0.461717306307778 no 1809 0.443112633602651 2740 5702181 A cholesterol synthesis inhibitor. SGTC_3284 9108171 64.8615 µM -0.144129352044629 0.461273806928229 no 1810 0.442699163560592 2761 8687505 SGTC_2516 gossypol 71.55 µM -0.144861659141651 0.460963683847953 no 1811 0.44241004931404 2790 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1736 st036774 51 µM -0.145061575636886 0.460879025779479 no 1812 0.442331127766855 2934 1272247 SGTC_459 nigericin 15.3 µM -0.145182830668776 0.460827679120271 no 1813 0.44228326072202 2779 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.145360193237916 0.460752574338321 no 1814 0.44221324599471 2866 165506 SGTC_722 3534-0461 190 µM -0.145361630517878 0.460751965722958 no 1815 0.442212678628901 2715 658262 SGTC_60 0986-0278 202 µM -0.145996427369229 0.460483170373278 no 1816 0.441962104377546 2664 3110598 SGTC_1031 k035-0009 16 µM -0.146815413224232 0.460136409603087 no 1817 0.441638859262563 2877 5180959 SGTC_851 0394-0702 453 µM -0.148070208077512 0.459605185051444 no 1818 0.441143680375102 2669 762646 SGTC_1691 st019933 84.6 µM -0.148532495155464 0.459409491309074 no 1819 0.440961271471219 2647 6176082 SGTC_1169 aniline yellow 25.8 µM -0.148840428259396 0.459279143603109 no 1820 0.440839774395378 2715 6051 A DNA damaging agent. SGTC_1155 4088-0394 48.2 µM -0.148964679668562 0.459226549372407 no 1821 0.44079075174288 2658 2326248 SGTC_2705 st078069 42.8 µM -0.149066479187824 0.459183459307188 no 1822 0.440750588025849 2741 1530061 SGTC_657 3534-0529 86.7 µM -0.149984153396376 0.458795044585745 no 1823 0.440388558794781 2821 1049549 SGTC_567 1080-0542 68.4 µM -0.150511454308161 0.458571877009605 no 1824 0.440180557224338 2668 5950415 SGTC_2046 4110841 106 µM -0.150752200154091 0.458469991390562 no 1825 0.440085596983493 2725 44119630 YMR134W ERG29 SGTC_1132 3456-3614 2.5 µM -0.15112671901658 0.458311497358453 no 1826 0.439937877917127 2941 3125502 SGTC_3190 9110366 49.47 µM -0.151245698824088 0.458261147236708 no 1827 0.439890951225789 2725 17123768 SGTC_2315 7733312 200 µM -0.15221757025675 0.457849893817648 no 1828 0.439507668191695 2709 726316 SGTC_2681 menadione 3.18 µM -0.152448034266202 0.45775237814638 no 1829 0.439416786957775 2723 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2163 5671233 125 µM -0.153382835031294 0.457356864330124 no 1830 0.439048190185944 2750 701023 SGTC_972 1319-0219 195 µM -0.15413252983659 0.457039699265125 no 1831 0.43875261982136 2742 23903702 SGTC_2992 9074591 71.4286 µM -0.154274266351363 0.456979739439534 no 1832 0.438696743431549 2691 17741321 SGTC_2452 5863136 48.41 µM -0.156576188624222 0.456006078646577 no 1833 0.437789434886411 2657 2184096 SGTC_1301 naphtanilide LB 4.81 µM -0.156693728085826 0.455956369164629 no 1834 0.437743115141239 2783 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_952 1185-0122 232 µM -0.157763686792511 0.455503896821809 no 1835 0.437321506993886 2649 678600 SGTC_3230 9131665 49.47 µM -0.15788608854292 0.455452138298573 no 1836 0.437273280150184 2679 15943720 SGTC_3270 9137563 49.47 µM -0.15792770255284 0.455434541666039 no 1837 0.437256884254172 2802 17015724 SGTC_3131 9127911 49.47 µM -0.158061090841897 0.455378138541648 no 1838 0.437204330071261 2924 45595681 SGTC_275 trichlorophene 5.69 µM -0.159024827148342 0.454970650259666 no 1839 0.436824656746882 2773 62616 SGTC_1856 st057054 55.7 µM -0.160029228675326 0.454546018277583 no 1840 0.436429024885026 2931 1266018 SGTC_579 4491-1009 110 µM -0.161704767761079 0.453837764534152 no 1841 0.43576917491436 2696 1271041 SGTC_856 0433-0016 11.3 µM -0.162035605011293 0.45369793624357 no 1842 0.435638907802767 2756 3911780 SGTC_1396 3511-0007 98.6 µM -0.163526459773112 0.453067898264144 no 1843 0.435051970828706 2813 X1396 SGTC_1818 st052136 56.3 µM -0.164351561639041 0.452719259365851 no 1844 0.434727196589568 2741 674169 SGTC_3205 9113483 49.47 µM -0.164967467253997 0.452459038083951 no 1845 0.434484794274954 2879 17018033 SGTC_2147 5545932 89.7195 µM -0.16509209960378 0.452406383161927 no 1846 0.43443574564504 2727 797404 SGTC_3004 9076122 71.4286 µM -0.165626382895023 0.452180667595301 no 1847 0.434225491750485 2831 44782551 SGTC_2015 5119600 184 µM -0.166834356620058 0.451670399016895 no 1848 0.433750192423699 2855 2828786 SGTC_2650 prasterone 100 µM -0.167869759945076 0.451233090610834 no 1849 0.433342870278678 2701 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1994 st072947 40.9 µM -0.16813519697335 0.451120991301345 no 1850 0.433238460151072 2805 5286565 YDL195W SEC31 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.168136111305168 0.451120605167658 no 1851 0.433238100505073 2801 616764 SGTC_142 0335-0849 62.6745 µM -0.16814015626173 0.451118896932796 no 1852 0.433236509450479 2720 3889043 YPR107C YTH1 SGTC_1089 terbinafine 2.25 µM -0.168324205971758 0.451041171436842 no 1853 0.433164115964958 2820 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2290 7904846 200 µM -0.169041029282107 0.450738469796631 no 1854 0.432882184526766 2788 2962154 SGTC_646 4092-0839 27.3 µM -0.169310975016775 0.450624483966191 no 1855 0.432776021897144 2824 877796 SGTC_2779 methotrexate 400 µM -0.169872312734531 0.450387469577218 no 1856 0.432555277930477 2710 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3338 9144300 39.5675 µM -0.169917861838933 0.45036823809178 no 1857 0.432537366837183 2778 4901274 SGTC_3290 9121031 71.43 µM -0.171519934013237 0.449691894689934 no 1858 0.431907478808618 2741 17014854 SGTC_1898 st060199 18.6 µM -0.171653630182922 0.449635459040999 no 1859 0.431854921178226 2704 688866 SGTC_249 wiskostatin 11.211 µM -0.171829917480678 0.449561046439199 no 1860 0.431785622288495 2706 2775510 A n-wasp and actin depolymerizer. SGTC_2551 apiole 73.87 µM -0.171911454816247 0.449526629327863 no 1861 0.431753570508476 2701 10659 A possible DNA adduct former. SGTC_690 glyoxal 20.3 µM -0.172722320825026 0.449184381482222 no 1862 0.431434848999626 2717 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_750 4073-0104 132 µM -0.172983661534631 0.449074083637929 no 1863 0.431332135111015 2786 22330957 SGTC_1044 1222-0021 1.78 µM -0.173688592252898 0.448776589979064 no 1864 0.431055101658446 2838 4306703 SGTC_1557 sumaresinolic acid 42.3 µM -0.174817387412831 0.448300277818091 no 1865 0.430611562773294 2713 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_18 0111-0177 500 nM -0.175991245633079 0.447805029669638 no 1866 0.430150410038189 2738 721752 SGTC_2644 guaiazulene 100 µM -0.177644433463994 0.44710769157245 no 1867 0.429501113320745 2815 3515 A coloring agent. SGTC_291 SEC14.278 35.5 µM -0.178233830616813 0.446859114908168 no 1868 0.429269671037716 2814 1068044 SGTC_1765 st044815 90.4 µM -0.178333751526534 0.446816975600152 no 1869 0.429230436874354 2805 645695 SGTC_728 3030-5151 22.5 µM -0.180042636910392 0.446096386477227 no 1870 0.428559547833655 2713 3125388 SGTC_2064 5220758 200 µM -0.180591306887799 0.445865065342498 no 1871 0.428344189894698 2865 788518 SGTC_1269 0831-0796 3.05 µM -0.182378819029049 0.44511157232655 no 1872 0.427642723501833 2837 927758 SGTC_2897 9048598 12.99 µM -0.182484961419065 0.445066836154517 no 1873 0.427601077629344 2747 6467404 SGTC_932 2857-0803 154 µM -0.182580302726782 0.445026652945545 no 1874 0.427563670341351 2952 674898 SGTC_1953 st076800 12.1 µM -0.184448927747102 0.444239203818706 no 1875 0.426830644705356 2752 297591 SGTC_1103 duloxetine 36.1 µM -0.186437529366725 0.443401437645899 no 1876 0.426050832070442 2906 60835 A selective serotonin reuptake inhibitor. SGTC_1450 4112-4260 37.6 µM -0.186867761080617 0.443220221031215 no 1877 0.425882158419682 2788 1633175 SGTC_987 1497-1013 404 µM -0.187979152743503 0.442752150121992 no 1878 0.42544649677385 2726 1676435 SGTC_1852 st056254 31.4 µM -0.188208113093408 0.442655731661813 no 1879 0.425356756405842 2767 442583 SGTC_702 1488-0190 94 µM -0.188662201821687 0.442464518491686 no 1880 0.425178789044558 2847 949357 SGTC_994 3910-0338 138 µM -0.188758958177986 0.442423776886354 no 1881 0.425140870069314 2909 3479481 SGTC_2415 st077333 57.7 µM -0.189465437001821 0.442126315362869 no 1882 0.424864020866594 2956 2766255 SGTC_284 0988-0104 32.6 µM -0.190482923928648 0.441697961867502 no 1883 0.424465361474069 2843 4666532 SGTC_45 0kpi-0036 14.9 µM -0.192053081791712 0.441037072478903 no 1884 0.423850312998737 2866 2795021 SGTC_1358 1509-0022 2.48 µM -0.192096449035538 0.441018821252679 no 1885 0.423833328187049 2811 3258434 SGTC_846 0335-0850 148 µM -0.193248751919497 0.440533917355668 no 1886 0.423382079872379 2750 6819598 SGTC_541 4513-1321 94 µM -0.193344565610925 0.440493601725171 no 1887 0.423344563206457 2779 747515 SGTC_171 k064-0041 9.68 µM -0.19421859819988 0.440125862617982 no 1888 0.423002360439398 2771 53325 SGTC_2826 7992541 19.48 µM -0.194248627147232 0.440113229201371 no 1889 0.422990604484092 2695 2985066 SGTC_1311 1190-0148 100 µM -0.194297578690544 0.440092635029089 no 1890 0.422971440717408 2867 1961333 SGTC_2990 9074105 71.4286 µM -0.194333482813292 0.440077530078439 no 1891 0.422957384928502 2772 6502001 SGTC_1259 0671-0132 43 µM -0.194574843279868 0.43997599141543 no 1892 0.422862899390889 2785 X1259 SGTC_248 streptozotocin 5.23457 mM -0.194844630011442 0.439862498694107 no 1893 0.422757291057067 2836 5300 DNA alkylating agent. SGTC_1906 st060206 94.7 µM -0.195387974618405 0.439633941830354 no 1894 0.4225446150268 2886 5133468 SGTC_1456 k015-0012 13 µM -0.195585173644854 0.43955099541121 no 1895 0.422467432934107 2750 2989616 SGTC_1764 st044502 93.5 µM -0.195847216760335 0.439440778192303 no 1896 0.422364875999634 2865 8407 SGTC_1369 1866-0067 208 µM -0.196046268554801 0.43935705871278 no 1897 0.42228697576485 2830 3531355 SGTC_2639 lactacystin 53 µM -0.19746582634635 0.438760083730151 no 1898 0.421731510763808 2897 3870 A proteasome inhibitor. SGTC_2995 9067767 71.4286 µM -0.197535936011592 0.438730603698896 no 1899 0.42170408127057 2842 11673567 SGTC_1426 4048-4480 71.7 µM -0.19843826738723 0.43835121768932 no 1900 0.42135108982634 2864 14224343 SGTC_2630 antimycin a 100 µM -0.199091815488789 0.438076468175501 no 1901 0.421095461685081 2697 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2013 4024628 200 µM -0.199725539959469 0.437810080953052 no 1902 0.4208476190989 2914 5230760 SGTC_2076 5212012 200 µM -0.19974516487681 0.437801832032972 no 1903 0.420839944512421 2710 604802 SGTC_523 1934-0222 13.7 µM -0.200143773856309 0.437634291010824 no 1904 0.42068406965331 2771 1361595 SGTC_2353 9059630 146.67 µM -0.200965642632646 0.437288883202631 no 1905 0.420362719584128 2873 4779114 SGTC_743 1275-0778 158 µM -0.201112331688509 0.437227239030114 no 1906 0.420305369849922 2880 2849257 YMR203W TOM40 SGTC_596 1155-0152 116 µM -0.201561640394144 0.437038432364697 no 1907 0.420129718096764 2757 280313 SGTC_3271 9137798 49.47 µM -0.204250801996287 0.435908705087474 no 1908 0.419078756886716 2909 6498326 SGTC_206 4546-0025 72.014 µM -0.205107110813938 0.435549075705542 no 1909 0.418744220457776 2802 6620745 YIL048W NEO1 SGTC_2249 haloperidol 116.36 µM -0.205390553803162 0.435430048102027 no 1910 0.418633499966524 2752 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1701 st028638 40.4 µM -0.205606040122584 0.435339561789408 no 1911 0.418549329499274 2879 3490878 SGTC_3253 9135987 49.47 µM -0.205663419982004 0.435315467596538 no 1912 0.418526917152413 2896 4182430 SGTC_3295 9122362 53.5725 µM -0.205825310352031 0.435247490024974 no 1913 0.418463684838172 2871 4730473 SGTC_1026 k007-1105 30.6 µM -0.206098584578014 0.435132746848732 no 1914 0.418356952190937 2777 7066794 SGTC_1519 esterone 74 µM -0.206102851392745 0.435130955329444 no 1915 0.418355285749798 2761 698 A steroid. SGTC_2883 9059145 45.46 µM -0.207991938962206 0.434337910241168 no 1916 0.417617630749111 2732 16476510 SGTC_362 0310-0100 9.03 µM -0.208662168803656 0.434056608903214 no 1917 0.417355987464042 2911 790235 SGTC_766 1391-0721 126 µM -0.209040461977038 0.433897850676103 no 1918 0.417208326108893 2962 1020919 YIL115C NUP159 SGTC_12 0849-0099 9.267 µM -0.212290366617418 0.432534405677073 no 1919 0.415940255243044 2782 6071388 SGTC_3330 9141424 71.43 µM -0.212366253253823 0.432502578195035 no 1920 0.415910655655959 2910 27261020 SGTC_2359 9039622 200 µM -0.212571315395598 0.432416575630482 no 1921 0.41583067354179 2771 6463596 SGTC_2119 5528445 120.635 µM -0.213449826567115 0.432048166469275 no 1922 0.415488059932537 2920 791935 SGTC_3024 9090631 49.47 µM -0.213693928080824 0.431945811446276 no 1923 0.415392873333107 2827 25236383 SGTC_2229 7354935 190 µM -0.214298283438103 0.431692416847913 no 1924 0.415157228282398 2860 318112 SGTC_2827 7993847 71.43 µM -0.214312834034751 0.431686316408144 no 1925 0.415151555214595 2902 2985692 SGTC_179 1273-0063 6.77 µM -0.214409548590936 0.431645768565773 no 1926 0.415113848053469 2795 3108139 SGTC_363 0455-0021 3.06 µM -0.215374788804892 0.431241128495177 no 1927 0.414737562199515 2779 4597466 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.215419884628357 0.431222225555629 no 1928 0.41471998411204 2890 7104 SGTC_1814 st052110 31.539 µM -0.21604943892696 0.430958350029658 no 1929 0.414474605386536 2899 674163 SGTC_825 1988-2224 89.6 µM -0.216266886116589 0.430867214940108 no 1930 0.414389859661405 2782 1180859 SGTC_884 0851-0618 334 µM -0.217229704792472 0.430463728773815 no 1931 0.414014668139235 2934 9642473 SGTC_828 2074-0507 139 µM -0.21760650757096 0.430305842655571 no 1932 0.413867856843257 2933 X828 SGTC_2784 7567673 72.73 µM -0.217885374360596 0.430189000385138 no 1933 0.413759211480243 2743 3471247 SGTC_2234 tolnaftate 200 µM -0.219115407317761 0.429673702510632 no 1934 0.413280074542639 2825 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_187 1488-2104 32.728 µM -0.219376258200131 0.429564439580672 no 1935 0.4131784814031 2855 2852859 SGTC_640 3381-0960 37.1 µM -0.220084075113186 0.429267982645925 no 1936 0.412902838489504 2848 1745025 SGTC_1662 st014054 52 µM -0.222831641619907 0.428117591122919 no 1937 0.41183327031752 2792 2838777 SGTC_686 1319-0111 510 µM -0.222975545440276 0.4280573561012 no 1938 0.411777269649348 2972 4562600 SGTC_1740 st038286 13.222 µM -0.223990646128369 0.427632504642251 no 1939 0.411382290820504 3006 716786 SGTC_1434 4073-0095 163 µM -0.224323195838383 0.427493340384726 no 1940 0.411252914204793 2819 24133745 SGTC_2188 6126565 140.678 µM -0.225519874568292 0.426992633149297 no 1941 0.410787432946192 2907 874518 SGTC_2601 securinine 100 µM -0.226504601543318 0.426580697680833 no 1942 0.410404490356104 2816 442872 A GABA receptor antagonist. SGTC_671 0560-0003 407 µM -0.227047540884542 0.426353607042134 no 1943 0.410193387525172 2861 3238678 SGTC_3098 9119039 49.47 µM -0.227086236677662 0.426337423011742 no 1944 0.410178343022252 2790 17161528 SGTC_1477 0139-0234 16 µM -0.227099394391147 0.426331919991278 no 1945 0.41017322747667 2794 620880 SGTC_2853 9015042 58.44 µM -0.228655216656099 0.425681321579881 no 1946 0.409568452281593 2766 6457456 SGTC_1281 0884-0031 11.8 µM -0.228852412128742 0.425598874729082 no 1947 0.409491814300149 2808 1548255 SGTC_1200 1643-0193 18.4 µM -0.229123346396196 0.425485603209318 no 1948 0.409386524139314 2810 5403974 SGTC_2125 5246583 200 µM -0.230413097838532 0.424946471631398 no 1949 0.408885392168284 2897 835267 SGTC_1243 0416-0003 5.65 µM -0.231081661784267 0.424667059048219 no 1950 0.408625680688935 2870 2141977 SGTC_3224 9130643 49.47 µM -0.231149372431898 0.424638762880749 no 1951 0.408599379931996 3009 17644395 SGTC_1779 st039427 55 µM -0.232457344808521 0.424092239769825 no 1952 0.408091406872435 2973 1124498 SGTC_1834 st055981 52.8 µM -0.232989842129547 0.423869782859803 no 1953 0.407884646771857 2973 471719 YDL150W RPC53 SGTC_1843 st055809 45.5 µM -0.233098115266673 0.423824553470802 no 1954 0.407842609199418 2956 16413835 SGTC_2341 7987486 176.74 µM -0.233269895127299 0.423752797212603 no 1955 0.40777591700956 2961 1258686 SGTC_683 panaxydol 45 µM -0.234180415301267 0.423372495009735 no 1956 0.407422459327815 2861 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3139 9095020 49.47 µM -0.234568299974101 0.423210506645023 no 1957 0.407271908033583 2756 25236292 SGTC_1929 genistein trimethyl ether 50.5 µM -0.237053662075448 0.422172879105219 no 1958 0.406307580061175 3014 136420 SGTC_2693 st077581 40.7 µM -0.237137118191383 0.422138045880857 no 1959 0.406275208662029 2925 25238761 SGTC_642 0335-0876 158 µM -0.238088809212042 0.421740868677276 no 1960 0.405906107080479 2817 6812350 SGTC_1674 st016616 23.6 µM -0.240115088274977 0.420895490256211 no 1961 0.405120518790802 2778 625830 SGTC_807 1315-0151 48 µM -0.240247046520457 0.42084044891702 no 1962 0.405069371805926 3064 4011080 SGTC_979 1426-2828 121 µM -0.240334140794445 0.420804121716624 no 1963 0.405035614974048 2963 747872 SGTC_703 3875-0075 71.8 µM -0.240518285400057 0.420727316844342 no 1964 0.404964244772818 2857 2850814 SGTC_1320 1313-0481 95.3 µM -0.240763872649265 0.42062488955642 no 1965 0.404869065739623 2980 6813365 YLR208W SEC13 SGTC_578 3460-0051 92 µM -0.241876995285115 0.420160706005295 no 1966 0.40443773801962 2862 2876744 SGTC_303 1348-1668 34.2 µM -0.242479532818458 0.41990948795103 no 1967 0.404204307083587 2858 5380509 SGTC_2773 thioridazine 9.09 µM -0.243237466215725 0.419593526514042 no 1968 0.403910722192584 2811 5452 An antipsychotic. SGTC_2771 fluoxetine 41.05 µM -0.243450656364121 0.419504662778133 no 1969 0.4038281529057 3027 3386 A selective serotonin reuptake inhibitor. SGTC_1659 st012954 42.1 µM -0.244292957810314 0.419153607697344 no 1970 0.403501968568817 2971 24207262 SGTC_450 aminopyrene 156 nM -0.245158700677889 0.418792849747408 no 1971 0.403166776396352 2941 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.24548695308746 0.41865608370583 no 1972 0.40303970454671 2811 2346 DNA damaging agent; causes G2/M arrest. SGTC_2862 9027634 71.43 µM -0.246806827367182 0.418106258801046 no 1973 0.402528863222813 2806 5012562 SGTC_2245 6637752 200 µM -0.247277380538812 0.417910277363043 no 1974 0.402346781516684 3000 681890 SGTC_1328 1441-0025 69.2 µM -0.247689513802028 0.417738644068559 no 1975 0.402187322939663 2813 4562601 SGTC_1146 3579-1023 7 µM -0.247839307746175 0.417676266116833 no 1976 0.402129370161559 2948 X1146 SGTC_620 0109-0052 432 µM -0.249317304015785 0.417060902723706 no 1977 0.4015576735954 2978 493037 SGTC_1260 0700-1617 7.75 µM -0.249427293289019 0.417015116818306 no 1978 0.401515137584195 2958 2853078 SGTC_3236 9132701 49.47 µM -0.249479571909963 0.416993354872577 no 1979 0.401494920348975 2893 24282524 SGTC_3038 9091290 49.47 µM -0.251009376453556 0.416356658234039 no 1980 0.400903429930913 2996 25236843 SGTC_2035 5154463 94.595 µM -0.251054613755738 0.41633783403764 no 1981 0.400885942630069 2974 2769623 SGTC_1547 harmine 94.2 µM -0.251932878004511 0.415972407821336 no 1982 0.400546473030034 2882 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3241 9133421 49.47 µM -0.251953324320809 0.415963901427943 no 1983 0.400538570945911 2882 17018221 SGTC_2272 7805186 180 µM -0.252296990041999 0.415820930183548 no 1984 0.400405757250615 2984 2956062 YPR165W RHO1 SGTC_1334 1486-0610 236 µM -0.253733687897742 0.415223358371658 no 1985 0.399850653181023 2942 3742339 SGTC_2515 chrysin 20.77 µM -0.254057108235026 0.415088863769846 no 1986 0.39972571952343 2946 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1126 isoteolin 1.0172 µM -0.25466912039943 0.414834385271396 no 1987 0.39948933417304 2850 133323 SGTC_1705 st027868 56.3335 µM -0.25475729665946 0.414797723971759 no 1988 0.399455279753379 2937 292948 SGTC_1583 clindamycin 39.6 µM -0.255858385017038 0.414339983857547 no 1989 0.39903009458753 2846 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2987 9018338 71.43 µM -0.256629857388547 0.41401933966381 no 1990 0.398732261929492 2825 5055682 SGTC_61 0978-8327 98.565 µM -0.257890930952006 0.413495327839584 no 1991 0.398245542118192 2904 6150059 YHR072W ERG7 SGTC_2973 9094665 17.96 µM -0.258033485749404 0.413436101952084 no 1992 0.398190532079818 3081 25237061 YIL048W NEO1 SGTC_804 1595-0054 20.9 µM -0.258437843471345 0.413268118011351 no 1993 0.398034506718321 2877 761523 Stimulates phospholipase C. SGTC_944 3370-0224 231 µM -0.258766613806786 0.413131547340553 no 1994 0.397907659501551 2903 4580514 SGTC_1380 2291-0730 164 µM -0.258831129774147 0.41310474874427 no 1995 0.397882769011925 2960 2999191 SGTC_971 1315-0384 26.7 µM -0.26050973792416 0.412407632363823 no 1996 0.397235302393894 2890 6769120 SGTC_2740 felodipine 17.08 µM -0.260554968099635 0.412388852342355 no 1997 0.397217860284262 2981 3333 L-type calcium channel blocker SGTC_497 capsazepine 133 µM -0.261967225367159 0.411802570114596 no 1998 0.396673355182866 2869 2733484 A calcium channel blocker. SGTC_2606 farnesol 9.78 µM -0.263185124490433 0.41129713142691 no 1999 0.39620394784832 3054 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1296 1068-0102 11.9 µM -0.264561607900701 0.41072605611184 no 2000 0.395673599480152 2966 767053 SGTC_867 0518-0118 155 µM -0.265557634572713 0.410312942561929 no 2001 0.395289958501695 2936 6848158 SGTC_1524 corynanthine 62.1 µM -0.266455687610677 0.409940549993412 no 2002 0.394944141135416 3054 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1760 st045453 10.4495 µM -0.266681494006217 0.409846928395282 no 2003 0.394857201847652 3002 3323419 YIL048W NEO1 SGTC_2329 6138490 200 µM -0.266741923116273 0.409821874751217 no 2004 0.394833936504327 3116 720019 SGTC_3223 9129970 49.47 µM -0.266843166378164 0.409779900563964 no 2005 0.394794958461234 2850 17248386 SGTC_1563 conessine 56.1 µM -0.26725867724758 0.409607645800268 no 2006 0.394635000324355 3000 441082 An anti-amoebic, histamine inhibitor. SGTC_3063 1327-0034 4 µM -0.267611770999345 0.409461280474965 no 2007 0.394499084701933 2955 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3058 9093861 49.47 µM -0.267770162121403 0.409395627880509 no 2008 0.39443811971777 3053 17217477 SGTC_51 1013-0126 23.419 µM -0.268169396691233 0.409230157754218 no 2009 0.394284465198984 3144 1627850 SGTC_3355 9151058 44.0485 µM -0.268478266087959 0.409102152233503 no 2010 0.394165601060545 2883 17015728 SGTC_1476 4112-3294 3.34 µM -0.268499697753307 0.409093270614 no 2011 0.394157353744516 3004 704369 SGTC_1967 st070177 51.4 µM -0.268574454450857 0.409062290627044 no 2012 0.394128586304472 3048 5729214 SGTC_2920 7982904 15.77 µM -0.269897983207897 0.408513900168423 no 2013 0.393619369393097 2985 6456808 SGTC_1366 1683-0113 21.9 µM -0.271044515611834 0.408038991044082 no 2014 0.39317839737037 2883 708623 SGTC_3176 9106582 49.47 µM -0.271095063891102 0.408018056371361 no 2015 0.393158958961335 2955 17018027 SGTC_527 4476-4215 268 µM -0.272143261845054 0.407584002319507 no 2016 0.392755933123359 2900 4418754 SGTC_1548 st061468 90.8 µM -0.272620663847585 0.407386349863371 no 2017 0.392572412986391 3005 390799 SGTC_921 1561-0023 372 µM -0.273962862977175 0.406830783334269 no 2018 0.392056580593574 2856 24050882 SGTC_3120 9124077 49.47 µM -0.274514880308151 0.406602345230162 no 2019 0.391844484929574 2896 18774327 YGL155W CDC43 SGTC_2813 7971799 71.43 µM -0.275346855168512 0.40625811400415 no 2020 0.391524884942461 2991 2234054 SGTC_1789 tunicamycin 25 nM -0.276944161337456 0.405597428725306 no 2021 0.390911491204664 3017 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1388 3346-4487 254 µM -0.277234890586648 0.405477204793393 no 2022 0.390799875185586 2972 3345614 SGTC_1699 st031318 29.054 µM -0.277919721524489 0.40519404505942 no 2023 0.390536992237165 3002 5340658 SGTC_2175 5807670 165.306 µM -0.278106396423614 0.405116868456919 no 2024 0.390465342862148 3032 241186 SGTC_94 0334-0113 514.748 µM -0.278618675355862 0.404905097043306 no 2025 0.390268739585871 2921 6795178 SGTC_3226 9131256 49.47 µM -0.279209760754294 0.404660782364432 no 2026 0.3900419266996 2901 17178073 SGTC_855 0428-0020 25 µM -0.280115925781374 0.404286307294162 no 2027 0.389694283306865 2916 6812414 SGTC_1139 k015-0024 46.9 µM -0.280644881796518 0.404067755341149 no 2028 0.389491394079548 3023 2766652 SGTC_2522 biochanin a 4.94 µM -0.281466520785618 0.403728333191972 no 2029 0.389176301531232 3022 5280373 A possible chelator. SGTC_321 4534-3890 65.3 µM -0.281506410359612 0.403711856502251 no 2030 0.389161006024037 3011 699746 SGTC_547 1120-0019 610 nM -0.281694175175128 0.403634301123136 no 2031 0.389089010618758 2870 3676939 SGTC_68 0986-0284 82.829 µM -0.283236933069633 0.402997215916067 no 2032 0.388497609253902 3086 423278 YIL048W NEO1 SGTC_3249 9135183 49.47 µM -0.283333513397956 0.402957341405626 no 2033 0.388460594696168 3072 4902779 SGTC_1832 st054113 55 µM -0.284424542280457 0.402506965388122 no 2034 0.388042526641755 3020 1251267 SGTC_287 k060-0039 29.6 µM -0.284645858717572 0.402415621869477 no 2035 0.387957736876368 3038 5861974 SGTC_1501 4491-0275 38.4 µM -0.285314388687134 0.402139733120683 no 2036 0.38770164511046 3002 5104718 SGTC_1594 piperine 70.1 µM -0.286204269499042 0.401772573022552 no 2037 0.387360836938315 2894 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1452 4194-0072 190 µM -0.288103704787049 0.400989166466795 no 2038 0.386633678399188 3071 1343545 SGTC_1946 st076057 65.1 µM -0.289195780433704 0.400538928766835 no 2039 0.386215780345664 2886 953009 SGTC_3116 9124943 49.47 µM -0.289387560125049 0.400459876027211 no 2040 0.386142406767342 2938 41905195 YPL160W CDC60 SGTC_3314 9135860 59.4275 µM -0.290582609303352 0.399967361571743 no 2041 0.385685281091686 3074 25252478 SGTC_583 1488-1091 88.9 µM -0.291693928591937 0.399509497363705 no 2042 0.385260325866576 3000 4303273 SGTC_1613 st002381 52.1 µM -0.294087919593012 0.398523641827823 no 2043 0.384345360852159 2932 551167 SGTC_765 1319-0117 244 µM -0.29479344679968 0.398233225961485 no 2044 0.384075836398301 2909 3487746 YGL099W LSG1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.294977541212791 0.398157456521615 no 2045 0.384005518140416 3010 5379071 SGTC_943 3253-1379 105 µM -0.295431345893698 0.397970696338955 no 2046 0.383832195381565 3112 668464 SGTC_2922 7999257 32.47 µM -0.295768089513234 0.397832126933911 no 2047 0.383703597063378 2913 2988377 SGTC_529 4076-0302 30.3 µM -0.296917233940746 0.397359353163349 no 2048 0.383264849202876 2934 5816522 SGTC_3119 9125183 49.47 µM -0.297857406031654 0.396972665565713 no 2049 0.382905999100875 2978 22695334 SGTC_143 4032-1194 15.74 µM -0.29835837225177 0.396766662254219 no 2050 0.382714828548424 2864 1806963 SGTC_3090 9117696 49.47 µM -0.298780256535307 0.396593200724998 no 2051 0.382553858114307 2994 7923821 SGTC_1912 st060209 90.8 µM -0.299611480780441 0.396251495284609 no 2052 0.382236762939479 3004 688787 SGTC_1151 3909-8316 15.3 µM -0.299708820085066 0.396211485573937 no 2053 0.382199635131719 3038 800431 SGTC_245 methotrexate 289.6 µM -0.301640608850227 0.395417682405312 no 2054 0.381463023822331 3023 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1805 st050013 60.3 µM -0.302379477695499 0.395114183764828 no 2055 0.381181398697431 2996 4037144 SGTC_1899 st063254 59.6 µM -0.302513720236531 0.395059048964156 no 2056 0.38113023794597 2897 3093813 SGTC_339 3091-4833 71.4 µM -0.303042872864511 0.39484174097841 no 2057 0.380928594499812 2943 3240077 SGTC_1239 0337-0584 35.4 µM -0.304920374277261 0.394070968732679 no 2058 0.380213398911153 3116 914301 YML130C ERO1 SGTC_3191 9110352 49.47 µM -0.305157562603458 0.393973625050358 no 2059 0.380123075965807 2955 17122424 SGTC_1098 clofazimine 15.1 µM -0.305478026948858 0.393842114851757 no 2060 0.380001051323753 3059 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2469 5655019 90.81 µM -0.305613195721289 0.393786648746433 no 2061 0.379949586086776 3071 2788239 SGTC_2029 5175081 200 µM -0.306176467092078 0.39355553521875 no 2062 0.379735144548715 2926 1380876 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.307118112746586 0.393169256290332 no 2063 0.379376735763191 2959 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1018 4259-0013 28.1 µM -0.3072272066564 0.393124510918479 no 2064 0.37933521917702 3085 6801262 SGTC_2815 7968870 71.43 µM -0.307276992713644 0.393104091405917 no 2065 0.37931627314514 2940 2977326 YHR190W ERG9 SGTC_1825 st052143 62.6 µM -0.307425406451737 0.393043221968513 no 2066 0.379259796172724 3119 674173 SGTC_2651 TUB2.036 5 µM -0.309572679047945 0.392162846984744 no 2067 0.378442967623154 3087 15992207 YFL037W TUB2 SGTC_2215 7188065 200 µM -0.310469823225594 0.391795183852557 no 2068 0.378101852020444 3071 940217 SGTC_2722 naftopidil 47.16 µM -0.310763775658788 0.391674738737187 no 2069 0.377990104948883 3069 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.311058539920155 0.391553971406253 no 2070 0.377878059507866 2928 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1492 4158-0558 28.5 µM -0.311853694213688 0.391228242337188 no 2071 0.37757585766067 3052 3967268 SGTC_637 1181-0519 7.26 µM -0.31255582717128 0.390940682170839 no 2072 0.377309071263845 2966 6252091 YGR060W ERG25 SGTC_2399 5884133 200 µM -0.313208520258179 0.390673423682737 no 2073 0.377061122819832 2964 722445 SGTC_3352 9151559 45.5865 µM -0.313380582462783 0.390602977901595 no 2074 0.376995767372436 3036 17159339 SGTC_1453 4237-0541 195 µM -0.313676977870438 0.390481635988876 no 2075 0.376883193942974 3083 739892 SGTC_2397 5161689 200 µM -0.314430109190182 0.390173358051633 no 2076 0.376597195536396 3158 2259942 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.314596829184395 0.390105124173647 no 2077 0.376533893479157 3015 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_835 0312-0010 67.2 µM -0.314660416806864 0.390079100412009 no 2078 0.376509750714923 2934 1626196 SGTC_1718 roemerine 11.9335 µM -0.315103093928302 0.3898979447887 no 2079 0.376341689740205 3110 235224 An aporphine alkaloid with mutagenic activity. SGTC_1885 st057546 99.9 µM -0.31526877564684 0.389830149431568 no 2080 0.376278795224532 3121 702008 SGTC_1836 st055642 81 µM -0.316004841941631 0.389528998768874 no 2081 0.375999416488513 2984 8571 SGTC_1875 nocodazole 6 µM -0.316288466273902 0.389412975750646 no 2082 0.375891782368371 3057 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2103 5378138 10 µM -0.318491289353917 0.388512196923523 no 2083 0.375056150512235 2976 244142 SGTC_2902 5787006 60.46 µM -0.318857150977301 0.388362646617497 no 2084 0.374917419066921 2962 591003 SGTC_2192 5915882 198.485 µM -0.31903081279058 0.388291666068844 no 2085 0.374851573728158 2953 2876149 SGTC_2561 acetosyringone 100 µM -0.319265584715569 0.3881957140017 no 2086 0.374762563775664 2927 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2719 novobiocin 32.65 µM -0.319324790835904 0.388171517340502 no 2087 0.374740117792405 3098 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1093 fluphenazine 7.97 µM -0.319385024289804 0.388146901268793 no 2088 0.374717282766096 2965 6602611 An atypical antipsychotic. SGTC_2670 beta-carotene 100 µM -0.319546279555269 0.388081002043763 no 2089 0.374656151654768 3080 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_265 mycophenolic acid 32.932 µM -0.320820056894761 0.387560568485152 no 2090 0.374173379494927 3231 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3313 9133968 57.047 µM -0.321082565000918 0.38745333930933 no 2091 0.374073911239296 2932 1494643 SGTC_2654 protoveratrine a 100 µM -0.322440393315925 0.386898831521815 no 2092 0.373559543709508 2982 5702278 A heart drug and vasodilator. SGTC_1995 st072814 61.1 µM -0.322998047844497 0.386671164231644 no 2093 0.373348360245417 2982 5769371 SGTC_2026 5148700 152 µM -0.323011232710709 0.38666578186746 no 2094 0.373343367603855 2942 79838 SGTC_1105 epirubicin 18.1 µM -0.325084219313615 0.385819813084415 no 2095 0.372558666024411 2964 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2412 st077135 33.4 µM -0.325488513271103 0.385654887168982 no 2096 0.372405687418406 3234 13258915 SGTC_1219 1469-0211 33.1 µM -0.326754139915491 0.385138726715326 no 2097 0.371926924034097 3097 6822282 SGTC_2908 7930301 100 µM -0.328174144350714 0.384559848575005 no 2098 0.371389998033465 2980 2223178 SGTC_3013 9080133 71.4286 µM -0.329213278478296 0.38413639875482 no 2099 0.370997243537516 3205 17050193 SGTC_3328 9140624 29.0385 µM -0.329457641045543 0.384036840443848 no 2100 0.370904902966973 3132 4904392 SGTC_2253 7938677 135.83 µM -0.329482082952323 0.384026882731656 no 2101 0.370895667183736 3174 2301972 SGTC_1469 k284-2957 126 µM -0.330762586729637 0.383505308553789 no 2102 0.370411911553286 3022 23884841 SGTC_1448 4255-0083 152 µM -0.330890612424134 0.383453172778947 no 2103 0.370363556567814 3140 5399660 SGTC_484 loperamide 105 µM -0.332294768460568 0.382881498417871 no 2104 0.369833344924963 2990 3955 An opioid-receptor agonist. SGTC_993 3909-8757 62.7 µM -0.332398787786143 0.382839159137765 no 2105 0.369794076884014 3013 4288324 YLR208W SEC13 SGTC_832 4083-0019 164 µM -0.33302260363859 0.382585274997483 no 2106 0.369558610428138 3126 1990758 SGTC_2146 5545642 200 µM -0.334867582329901 0.381834690684364 no 2107 0.368862488600171 3051 825326 SGTC_1300 1094-0077 113 µM -0.336209150790968 0.381289185104328 no 2108 0.368356576416426 3000 5532636 SGTC_1251 0490-5699 265 µM -0.337912565275728 0.38059688634541 no 2109 0.367714539127314 3181 3883818 SGTC_1654 st012436 41.8 µM -0.338280109212153 0.380447559830419 no 2110 0.367576055824427 3085 4323132 SGTC_1376 2910-0861 41.3 µM -0.338314567243643 0.380433561062662 no 2111 0.367563073600556 2981 1112859 SGTC_2097 5376186 200 µM -0.339184419389954 0.380080230682708 no 2112 0.367235402920527 3133 742755 SGTC_1289 0976-0073 69.1 µM -0.339832620459029 0.379816999109111 no 2113 0.366991290374353 3111 3391136 SGTC_1846 st056244 14.8 µM -0.340310863269904 0.379622822514999 no 2114 0.366811218578067 3050 5393182 SGTC_2622 2-methoxyxanthone 59.94 µM -0.34252674637218 0.378723524436409 no 2115 0.365977259627914 3050 71034 A hepatoprotective. SGTC_2943 9068529 45.32 µM -0.343767415559701 0.378220295223418 no 2116 0.365510603505894 3003 3270634 SGTC_2928 9011484 9.79 µM -0.344312809116897 0.377999142827532 no 2117 0.365305526137698 3129 2994751 SGTC_1284 0929-0043 16 µM -0.344771706776066 0.37781309473747 no 2118 0.365133002545111 3057 1239883 SGTC_2752 diclazuril 33.15 µM -0.345190073222382 0.377643503665058 no 2119 0.364975740535178 3127 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1096 rimcazole 32.2 µM -0.345447011484252 0.377539361600523 no 2120 0.364879169886959 2997 18528119 A dopamine reuptake inhibitor. SGTC_3164 9100705 49.47 µM -0.348329737600839 0.37637154866819 no 2121 0.363796281607067 3142 17174235 SGTC_2584 androsterone 48.74 µM -0.348996973172012 0.376101407541407 no 2122 0.363545790969076 3139 2754130 A steroid. SGTC_927 2425-1185 123 µM -0.34939685754696 0.375939536955629 no 2123 0.363395696084074 2980 730375 SGTC_548 1436-0017 110 µM -0.349670857814105 0.375828636035175 no 2124 0.363292863364458 3169 9677137 SGTC_2150 5556613 200 µM -0.349743753370337 0.375799133468602 no 2125 0.363265507209521 3054 743190 SGTC_439 amiodarone 34.4 µM -0.350921130083904 0.375322721770924 no 2126 0.36282375941225 3027 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_520 3584-0023 682 µM -0.352195662320382 0.374807211510868 no 2127 0.362345764890604 3064 1340790 SGTC_1500 4488-1866 171 µM -0.353339338214226 0.374344819061032 no 2128 0.361917028701192 3153 2900003 SGTC_3234 9132280 49.47 µM -0.354658789075905 0.373811584623209 no 2129 0.361422613995631 3099 17612295 SGTC_457 grayanotoxin iii 135 µM -0.35566552636095 0.373404890572718 no 2130 0.361045532504588 3115 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3173 9105693 49.47 µM -0.35613947397657 0.373213477605984 no 2131 0.360868058354709 3194 17096658 SGTC_1265 0819-1001 68.8 µM -0.356918928410814 0.372898747821837 no 2132 0.36057624945332 3082 3106768 SGTC_768 0384-0033 77.3 µM -0.360397900020122 0.371495038012228 no 2133 0.359274798403876 3045 3965305 YMR134W ERG29 SGTC_495 decylubiquinone 155 µM -0.360839462037436 0.371316996458982 no 2134 0.359109730484313 3096 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1944 st076371 56.9 µM -0.361516285761627 0.371044148844101 no 2135 0.358856766383901 3011 24208455 SGTC_2020 4017018 200 µM -0.362075755582146 0.37081865897508 no 2136 0.358647710236993 3146 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2868 9035608 32.47 µM -0.362126420253396 0.37079824117086 no 2137 0.35862878054459 3001 6462614 SGTC_3277 9138724 49.47 µM -0.364747303714893 0.369742525570806 no 2138 0.357650022192174 3080 15943418 SGTC_693 4161-2696 114 µM -0.366628714305565 0.36898528073138 no 2139 0.356947993294659 3158 805759 SGTC_462 ag-879 158 µM -0.368659509928283 0.368168480632906 no 2140 0.356190766239507 3154 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2284 7945075 39.21 µM -0.369480346540405 0.367838503248851 no 2141 0.355884859826473 3192 1245402 SGTC_1222 0366-0074 1.18 µM -0.370180384983939 0.367557163919188 no 2142 0.355624045319783 3181 286520 SGTC_1877 wortmannin 25 µM -0.37080836493035 0.367304844731852 no 2143 0.355390135268513 3189 312145 A covalent inhibitor of PI 3-kinase. SGTC_2504 purpurogallin 52.29 µM -0.370930619604895 0.367255730076469 no 2144 0.355344604162486 3021 5281571 An antioxidant. SGTC_307 1501-1223 22.3 µM -0.371586723320656 0.366992183757374 no 2145 0.355100287829938 3140 2830329 SGTC_92 0063-0024 660.874 µM -0.372719525025211 0.366537303086487 no 2146 0.354678601529176 3092 3594437 SGTC_2607 solasodine 47.35 µM -0.373171837311371 0.366355727750713 no 2147 0.354510277636022 3074 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_794 k038-0031 316 µM -0.373172936322386 0.366355286602354 no 2148 0.354509868683679 3144 6624242 SGTC_1279 0874-0590 65.2 µM -0.373950028035188 0.366043402456917 no 2149 0.354220747554456 3108 3523074 SGTC_831 k061-1017 217 µM -0.374613621049137 0.365777140815426 no 2150 0.353973920714076 3134 1240153 SGTC_1468 k284-1086 134 µM -0.374730020948336 0.365730442903302 no 2151 0.353930631493833 3092 15996457 SGTC_790 1575-0012 79.1 µM -0.375226696072303 0.365531206579442 no 2152 0.353745938821784 3205 378741 YLR208W SEC13 SGTC_2024 5144227 134 µM -0.37663440143044 0.364966716733016 no 2153 0.353222659310719 3194 3475211 SGTC_2602 kawain 100 µM -0.377284927742289 0.364705954436128 no 2154 0.352980935957653 3139 5369129 SGTC_84 0443-0269 128.823 µM -0.379056636686313 0.363996085726073 no 2155 0.352322903242402 3185 6150058 SGTC_1641 st009299 47.1 µM -0.379767793362314 0.363711278400463 no 2156 0.352058895771956 3155 4046054 SGTC_1698 5-fluorocytosine 1.055 µM -0.381165145126954 0.363151879923236 no 2157 0.351540355259956 3201 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3056 9094900 49.47 µM -0.383571174809424 0.362189364155982 no 2158 0.350648153951461 3096 25236784 SGTC_3046 9092212 49.47 µM -0.383624470865423 0.362168053267486 no 2159 0.350628400066991 3142 25236637 SGTC_2115 tiliquinol 12.7705 µM -0.385266991642753 0.361511486910109 no 2160 0.350019807203701 3137 71208 A bioactive hydroxyquinoline. SGTC_234 nsc-17383 10.7 µM -0.386193909496125 0.361141148950035 no 2161 0.349676532026247 3225 408974 SGTC_2170 morpholine 200 µM -0.388029513288391 0.360408141600259 no 2162 0.348997096491585 3186 121171 Reacts with secondary amines. SGTC_2964 9083345 53.42 µM -0.388506998173011 0.360217552610313 no 2163 0.348820438105829 3126 17741579 SGTC_2564 betulinic acid 100 µM -0.391242644858993 0.359126284960568 no 2164 0.347808944687943 3346 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2465 5809242 33.21 µM -0.392173702784137 0.35875514125362 no 2165 0.347464936560617 3099 2731748 SGTC_2211 7117706 200 µM -0.392280842133615 0.358712441292522 no 2166 0.347425358669054 3178 822771 SGTC_761 k216-0224 480 µM -0.393546312598068 0.358208226817461 no 2167 0.346958012562165 3268 1340404 SGTC_1206 3978-0017 132 µM -0.39433535888213 0.35789396399863 no 2168 0.346666730601617 3340 3873677 SGTC_1390 3413-2614 145 µM -0.39627735076882 0.357120914358133 no 2169 0.345950216987348 3151 3421432 SGTC_2750 bromebric acid 70.15 µM -0.3963735944579 0.357082617806009 no 2170 0.345914721416305 3250 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_109 0132-0036 33.701 µM -0.396882147478805 0.356880282193871 no 2171 0.345727184801934 3027 67274 A color developer. SGTC_1702 st027038 51 µM -0.397963810299472 0.356450059990671 no 2172 0.345328431195459 3150 5521182 SGTC_2351 9026858 72.31 µM -0.398282644862736 0.356323281072243 no 2173 0.345210925974198 3042 1409300 SGTC_53 0973-0023 39.979 µM -0.399102748079927 0.355997254525769 no 2174 0.344908748738901 3281 674768 SGTC_2390 9097792 176.6 µM -0.401824393537384 0.354916038122785 no 2175 0.343906634189513 3128 4497149 SGTC_1119 parthenolide 318.541 nM -0.402487034272503 0.354652970069163 no 2176 0.343662814296823 3289 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2262 9014885 67.46 µM -0.403536257960318 0.354236570557251 no 2177 0.343276883504193 3081 6457424 SGTC_540 1187-0821 17.3 µM -0.403701945260873 0.354170831083822 no 2178 0.343215954485628 3129 847520 SGTC_861 0443-0273 110 µM -0.404288678330307 0.353938068939369 no 2179 0.343000224981261 3207 6149169 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.405050452851597 0.353635947756943 no 2180 0.342720212738601 3332 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1484 3473-2379 286 µM -0.405205401002087 0.353574506308896 no 2181 0.342663267635779 3228 671917 SGTC_270 tamoxifen 5.46 µM -0.405238799794419 0.35356126321609 no 2182 0.342650993690655 3314 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3199 9111318 49.47 µM -0.40591208980902 0.353294332039814 no 2183 0.342403597293949 3202 8548020 SGTC_1952 st077036 64.1 µM -0.406142436033493 0.353203026007423 no 2184 0.342318973464689 3162 2937007 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.407384997396285 0.352710637851563 no 2185 0.341862622033194 3346 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_865 0488-0499 301 µM -0.408713952896198 0.352184287357217 no 2186 0.34137479651724 3278 9634651 SGTC_1803 st050068 52.4 µM -0.409970969677056 0.351686689577931 no 2187 0.340913621625799 3228 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2876 9059903 25.97 µM -0.410078153870431 0.351644271799616 no 2188 0.340874308825089 3234 6916095 SGTC_1475 4092-1048 11.7 µM -0.410642100417234 0.351421122315651 no 2189 0.340667494127704 3213 2881759 SGTC_95 0471-0001 561.058 µM -0.411343409755279 0.351143690821576 no 2190 0.340410371531756 3141 4015405 SGTC_20 0481-0013 4.944 µM -0.412282282980067 0.350772405432798 no 2191 0.340066266482914 3177 182045 SGTC_3077 9117319 49.47 µM -0.413196944950787 0.350410831585707 no 2192 0.339731163126946 3171 17154678 SGTC_430 0958-0115 16.4 µM -0.413577685368582 0.350260361506011 no 2193 0.33959170913355 3121 6833180 SGTC_1046 2001-0062 216 µM -0.414462574340964 0.349910740789872 no 2194 0.339267685230473 3102 739778 SGTC_3095 9117207 49.47 µM -0.415290973433961 0.349583554571484 no 2195 0.338964454164454 3204 17015229 SGTC_612 0302-0167 22.4 µM -0.415295338884523 0.349581830679777 no 2196 0.338962856490697 3185 235821 SGTC_3025 9087895 49.47 µM -0.415707533084367 0.349419071502865 no 2197 0.338812014127915 3255 17173641 SGTC_2187 6125751 200 µM -0.415872796040885 0.349353823474378 no 2198 0.338751543448089 3175 874498 SGTC_1216 1165-0504 9.65 µM -0.416207906520749 0.349221531035968 no 2199 0.338628937327674 3257 6304004 SGTC_2946 9065502 71.43 µM -0.416906128943931 0.348945950809594 no 2200 0.338373535197181 3150 16489101 SGTC_279 1273-0055 2.93 µM -0.41741232327635 0.34874621162312 no 2201 0.338188421317835 3200 2847562 SGTC_1445 4239-0156 97.7 µM -0.417782500140914 0.348600170090311 no 2202 0.338053073408888 3315 4008346 SGTC_1125 tnp00248 1.32998 µM -0.417920356411524 0.34854578900621 no 2203 0.338002674315672 3290 24207736 SGTC_3273 9137859 49.47 µM -0.418913206194019 0.348154224906441 no 2204 0.337639782592087 3233 2377234 SGTC_285 1486-1325 46 µM -0.41905668262824 0.348097653464207 no 2205 0.337587353686397 3255 22310230 SGTC_2982 9019404 25.97 µM -0.420244639478688 0.34762938293608 no 2206 0.337153373769856 3123 22333232 SGTC_2368 9071271 200 µM -0.421287893774476 0.347218343081144 no 2207 0.336772434661765 3168 27209959 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.423314637780718 0.346420324349502 no 2208 0.336032857963493 3201 97141 SGTC_949 1165-0505 146 µM -0.423866408027328 0.346203185831529 no 2209 0.335831621886641 3144 6244267 SGTC_127 0180-0333 59.125 µM -0.425074089654486 0.345728102542805 no 2210 0.335391332718672 3224 771601 SGTC_1037 k284-1091 78.7 µM -0.425759500674767 0.345458580405651 no 2211 0.335141550249972 3190 3334711 SGTC_3317 9138495 8.753 µM -0.428298700668394 0.344460781920759 no 2212 0.334216832396242 3195 17020139 SGTC_894 0960-0238 55.9 µM -0.428478408370789 0.344390205270615 no 2213 0.334151425039257 3278 6741907 YDL195W SEC31 SGTC_2885 9057732 51.95 µM -0.428954848911621 0.344203118888077 no 2214 0.333978041623644 3301 6471414 SGTC_2330 7979373 200 µM -0.431901888045958 0.343046738459019 no 2215 0.332906361244062 3124 1863007 SGTC_1391 3442-0225 151 µM -0.432913962287373 0.34264995166919 no 2216 0.332538638098401 3126 5227075 SGTC_843 0310-0051 143 µM -0.433265872641339 0.342512024783818 no 2217 0.332410814076225 3204 2065037 SGTC_2108 5365811 200 µM -0.433458136667607 0.342436678159145 no 2218 0.33234098645045 3252 780283 SGTC_2528 xanthyletin 44.79 µM -0.433657516853159 0.342358549395228 no 2219 0.332268580480554 3132 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1271 0832-2808 169 µM -0.43429532881774 0.342108662857407 no 2220 0.332036997744974 3284 3663794 SGTC_2082 5219693 150 µM -0.434669837709197 0.341961967289427 no 2221 0.331901047435241 3168 2834649 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.435418855253718 0.341668647828174 no 2222 0.331629213305458 3234 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2954 9074818 52.69 µM -0.437535343241824 0.340840336377512 no 2223 0.330861575072593 3303 16648742 SGTC_1992 st073643 23.3 µM -0.439497705772367 0.34007302848917 no 2224 0.330150472016103 3156 3161292 SGTC_2323 6148992 148.28 µM -0.440084190608051 0.339843834031937 no 2225 0.329938065869379 3165 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2267 7931562 200 µM -0.441571970288123 0.339262685105784 no 2226 0.329399485445077 3117 934880 SGTC_331 k048-0133 24.5 µM -0.442081444508598 0.339063764645461 no 2227 0.329215135598564 3170 6813582 SGTC_2543 pimpinellin 60.67 µM -0.443188502275396 0.338631676785141 no 2228 0.328814697305279 3160 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3030 9087619 49.47 µM -0.443536087228068 0.338496057136533 no 2229 0.328689011459785 3215 25236973 SGTC_3007 9078383 71.4286 µM -0.445084357328561 0.337892212406134 no 2230 0.328129396417825 3188 6496995 SGTC_2549 cedrol 20.94 µM -0.445152295730831 0.337865725116581 no 2231 0.328104849218924 3293 6708665 A sedative which affects the nervous system. SGTC_2114 5491910 81.25 µM -0.447678188103295 0.336881520863115 no 2232 0.327192732772927 3289 2849228 SGTC_1546 5-methoxyflavanone 78.7 µM -0.448149587317333 0.336697965327962 no 2233 0.327022621400036 3263 147795 SGTC_2461 5755302 26.15 µM -0.449163708794882 0.336303214063174 no 2234 0.326656782520742 3309 2788904 SGTC_2916 7875993 68.79 µM -0.449813854918331 0.336050236683299 no 2235 0.32642233341924 3341 1299250 SGTC_2798 7813637 45.45 µM -0.449860181286385 0.336032213532251 no 2236 0.326405630289713 3311 956368 SGTC_1009 4106-0057 9.87 µM -0.450833164054619 0.335653764318745 no 2237 0.326054898519236 3339 2928005 SGTC_1711 st032263 62.8 µM -0.450943682133457 0.335610787984595 no 2238 0.326015069714073 3236 3958979 SGTC_1192 1488-0095 21.4 µM -0.451691189307806 0.335320166973379 no 2239 0.325745733184402 3276 915875 SGTC_2084 5306078 60.6385 µM -0.451878286269638 0.33524744153194 no 2240 0.325678333944804 3195 679340 SGTC_1315 1237-0019 3.69 µM -0.452166915994855 0.335135261953468 no 2241 0.325574370027797 3313 825140 SGTC_677 0929-0063 136 µM -0.452497635901878 0.335006741571749 no 2242 0.325455261981406 3255 1539583 SGTC_3034 9090421 49.47 µM -0.45292419937148 0.33484100414796 no 2243 0.325301662407883 3257 17173761 SGTC_415 dibenzyl ketone 100 µM -0.453211420182355 0.33472942518692 no 2244 0.32519825490308 3256 7593 SGTC_1996 st072960 66.8 µM -0.454402291319245 0.334266953731429 no 2245 0.324769651743528 3325 1719405 SGTC_3308 9128332 17.569 µM -0.455305278980691 0.333916448594179 no 2246 0.324444814474489 3330 17332805 YDL196W YDL196W SGTC_398 bronopol 33.3 µM -0.457730051556011 0.332975962359473 no 2247 0.323573197481566 3154 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1292 0kpi-0043 232 µM -0.457917278299453 0.332903387098451 no 2248 0.323505936478083 3256 3333905 SGTC_2624 nerol 100 µM -0.458452725409077 0.332695864694368 no 2249 0.32331360952081 3230 637566 A natural product oil. SGTC_740 k014-0057 261 µM -0.458575709979018 0.332648206991323 no 2250 0.323269441424645 3279 4012779 SGTC_3128 9127691 49.47 µM -0.461035242005703 0.331695683425415 no 2251 0.322386660463304 3291 41316314 SGTC_2511 berberine 10.47 µM -0.46211079676974 0.331279485599206 no 2252 0.32200093400162 3210 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_300 r073-0011 5.04 µM -0.462207569055457 0.331242048699039 no 2253 0.321966237926903 3316 2735780 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.463352884042958 0.330799105378823 no 2254 0.321555722449808 3181 279621 SGTC_1526 st051518 75 µM -0.464072290470037 0.330521000537587 no 2255 0.32129797680308 3212 673993 SGTC_2434 5670830 169.91 µM -0.464717881575533 0.330271510527649 no 2256 0.32106675061631 3295 1549830 SGTC_412 gemfibrozil 100 µM -0.464737926134607 0.330263765473516 no 2257 0.321059572527225 3297 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1798 st045719 60.953 µM -0.464767776584757 0.330252231637842 no 2258 0.321048883007671 3292 3980186 SGTC_2337 9009472 200 µM -0.465869794454203 0.329826538866271 no 2259 0.320654351562466 3406 5742383 SGTC_478 N-arachidonylglycine 10 µM -0.467080135700803 0.329359256281176 no 2260 0.320221272807618 3265 5283389 SGTC_3255 9139072 49.47 µM -0.467251023579321 0.329293302175368 no 2261 0.320160146197631 3301 17646060 SGTC_1332 1480-0653 17.5 µM -0.468721831921062 0.328725864085614 no 2262 0.319634239840248 3324 5749438 SGTC_3100 9120536 49.47 µM -0.469001733044999 0.328617922845591 no 2263 0.319534198631286 3256 16421196 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.47080923370349 0.327921221822584 no 2264 0.318888485008303 3250 688761 SGTC_2724 maprotiline 69.64 µM -0.471549185159957 0.327636180068747 no 2265 0.318624302255262 3355 4011 A tricyclic antidepressant. SGTC_1189 1431-2119 7.28 µM -0.472343995957276 0.327330117437837 no 2266 0.318340635897849 3332 3107275 SGTC_2514 salinomycin 42.74 µM -0.472507004994752 0.327267360889191 no 2267 0.318282471457171 3355 23682228 A polyether potassium ionophore. SGTC_2428 5615643 7.78 µM -0.475126143563721 0.326259694035292 no 2268 0.317348532645151 3304 2253075 SGTC_244 nsc-207895 1.295 µM -0.475705750953113 0.326036871383037 no 2269 0.317142011613791 3217 42640 SGTC_66 0109-0187 42.4 µM -0.476129225636939 0.325874111211015 no 2270 0.316991158521118 3352 759417 SGTC_2432 5630864 12.22 µM -0.476363966560506 0.325783904115178 no 2271 0.316907550579755 3352 5714970 SGTC_3327 9140648 26.9345 µM -0.476389901293099 0.325773938447366 no 2272 0.316898313950016 3335 8029710 SGTC_1231 0242-0792 125 µM -0.476952086457435 0.325557944056832 no 2273 0.316698120308052 3217 3707635 SGTC_2513 baicalein 25.65 µM -0.477220104582613 0.325454990744585 no 2274 0.316602698179913 3265 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.477786985476241 0.325237279701184 no 2275 0.316400912557995 3395 23847180 SGTC_772 k072-0172 35.3 µM -0.479168418104258 0.324706989302171 no 2276 0.315909409910648 3248 5861980 SGTC_1750 st081859 2.357 µM -0.480541057371087 0.324180426087437 no 2277 0.315421358007359 3347 5291695 SGTC_2677 mitomycin C 100 µM -0.481000194442467 0.324004373216784 no 2278 0.315258180263697 3298 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_472 calcifediol 10 µM -0.482031122634324 0.323609214517839 no 2279 0.314891918748504 3296 5283731 A vitamin D metabolite. SGTC_1335 1486-0900 202 µM -0.483301166250333 0.323122675312293 no 2280 0.314440956047177 3304 X1335 SGTC_1293 1000-1278 195 µM -0.483538172673813 0.323031914319547 no 2281 0.314356831246327 3374 678847 SGTC_2728 chlorpromazine 9.18 µM -0.485277180312409 0.32236628843241 no 2282 0.313739870205688 3277 2726 A thorazine and dopamine antagonist. SGTC_1609 st001574 46.4 µM -0.486258119597172 0.321991073138569 no 2283 0.313392084362303 3240 3960012 SGTC_2455 5377712 9.75 µM -0.486292003149505 0.321978115710908 no 2284 0.313380074124169 3303 2243908 SGTC_1474 0330-0125 5.35 µM -0.48641856502968 0.321929719027598 no 2285 0.313335215220268 3362 X1474 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.486841888640369 0.321767863967237 no 2286 0.31318519142811 3297 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1092 toremifene 6.32 µM -0.488234470421831 0.321235658005857 no 2287 0.312691885578159 3297 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2305 7443522 69.23 µM -0.488764244216868 0.321033289498105 no 2288 0.312504307390289 3302 5415886 SGTC_2438 5259590 200 µM -0.48905422812672 0.320922540929195 no 2289 0.312401652705418 3316 1201127 SGTC_2116 5511452 16.8835 µM -0.489600707329858 0.320713876829675 no 2290 0.31220823792112 3362 870744 SGTC_386 1509-0011 3.07 µM -0.489790009559327 0.320641608089535 no 2291 0.31214125045499 3306 3107280 SGTC_2320 7373003 200 µM -0.490208091713364 0.320482023543447 no 2292 0.311993327749014 3318 5415828 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.490402317633874 0.320407897594552 no 2293 0.311924618495206 3370 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2157 5649910 96.377 µM -0.491548177021856 0.319970728454484 no 2294 0.311519393170303 3243 2858091 SGTC_1100 amiodarone 5.07 µM -0.494301837560886 0.318921172487971 no 2295 0.310546513790839 3367 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_456 gingerol 170 µM -0.495476714884501 0.318473809647389 no 2296 0.310131827320642 3432 442793 A herb. SGTC_2848 9016370 25.97 µM -0.495483607719431 0.318471185814394 no 2297 0.310129395126892 3415 7894410 SGTC_1174 0739-0097 51.1 µM -0.495941600590416 0.318296866225074 no 2298 0.309967807175401 3286 728447 SGTC_2832 7992762 51.95 µM -0.496584308889274 0.318052308761554 no 2299 0.30974111025828 3148 2985177 SGTC_3204 9114183 49.47 µM -0.498450987109349 0.317342467497966 no 2300 0.309083103481801 3229 17027248 SGTC_1264 0783-0040 158 µM -0.498710731280244 0.317243747792668 no 2301 0.308991591746692 3230 2855798 SGTC_1109 tnp00067 928.257 nM -0.499636493654079 0.31689200357501 no 2302 0.308665528334532 3322 676295 SGTC_781 4335-2806 94.4 µM -0.500361516952987 0.316616645838971 no 2303 0.308410272647133 3394 845254 SGTC_24 0417-1663 219 µM -0.501844998640678 0.316053548730888 no 2304 0.307888278562185 3360 4329390 SGTC_3165 9101544 49.47 µM -0.502728837532802 0.31571826550685 no 2305 0.307577465959852 3370 5002184 SGTC_2094 5332512 191.667 µM -0.503008373630643 0.315612255365588 no 2306 0.307479192452484 3397 755774 SGTC_310 1273-0058 1.06 µM -0.503566504926374 0.315400637297212 no 2307 0.307283017560864 3381 2734232 SGTC_1444 4112-3581 28 µM -0.504198382827972 0.315161130926266 no 2308 0.307060988366901 3348 2877249 SGTC_974 1326-0144 138 µM -0.504742994624156 0.314954764133265 no 2309 0.306869679474396 3303 5411856 SGTC_322 k048-0136 19.3 µM -0.50608477955213 0.314446575391889 no 2310 0.306398567475808 3355 6823282 SGTC_2143 5623677 140.463 µM -0.506197198166163 0.314404013813809 no 2311 0.306359110863519 3350 5375313 SGTC_3261 9137475 49.47 µM -0.506814059567835 0.314170514605406 no 2312 0.306142645219867 3276 17027690 SGTC_1362 1611-0397 101 µM -0.507187180403639 0.314029314069007 no 2313 0.306011744526227 3298 27816 SGTC_190 3970-0790 3.722 µM -0.507926100123934 0.313749764199544 no 2314 0.305752584985213 3358 2832352 SGTC_664 1222-0054 14.9 µM -0.508374687766412 0.313580105588329 no 2315 0.305595300350482 3350 6813991 SGTC_132 0417-1715 25.805 µM -0.508518531440622 0.313525711370509 no 2316 0.305544873206414 3444 6769098 SGTC_4 0960-0234 25.671 µM -0.509903140061132 0.31300233169995 no 2317 0.305059660985455 3369 6821112 SGTC_2139 5578692 56.4705 µM -0.509923449180841 0.312994657687764 no 2318 0.305052546551195 3348 650991 YMR113W FOL3 SGTC_2195 6536160 144.242 µM -0.510594288387043 0.312741219666621 no 2319 0.304817588058547 3262 3834386 SGTC_3064 1327-0027 10 µM -0.510715617678735 0.312695391817321 no 2320 0.304775101596122 3314 16000455 YPR107C YTH1 SGTC_2937 9044753 11.33 µM -0.510763112634652 0.312677453065819 no 2321 0.304758470775609 3314 6465530 YGL099W LSG1 SGTC_913 3487-1245 167 µM -0.510835000757702 0.312650301907106 no 2322 0.304733299217957 3243 4016153 SGTC_1859 st055998 20 µM -0.511714750933607 0.312318114709968 no 2323 0.304425330436235 3443 676301 SGTC_1993 st073995 70.8 µM -0.511872639707919 0.312258513201694 no 2324 0.304370073940805 3323 3098394 SGTC_3333 9141820 12.094 µM -0.512225872766113 0.312125188878339 no 2325 0.304246468779393 3278 1939433 SGTC_1401 3807-4679 7.6 µM -0.512995708576018 0.311834707225165 no 2326 0.303977161293924 3363 3291456 SGTC_533 1222-0222 6.71 µM -0.513834353221451 0.311518395143362 no 2327 0.303683903806546 3439 3982874 SGTC_1773 st048542 73.5835 µM -0.514359974162089 0.311320217264305 no 2328 0.303500168932012 3278 3237138 SGTC_1686 st019653 115.5 µM -0.516769489920446 0.310412444137809 no 2329 0.302658540294489 3394 97252 SGTC_517 1365-0151 113 µM -0.518516172782857 0.309755110832169 no 2330 0.30204908957949 3438 768657 SGTC_1368 1852-0141 284 µM -0.51904978454903 0.309554416574412 no 2331 0.301863012291626 3380 2838987 SGTC_1730 st033808 45.1 µM -0.51966815933772 0.309321913509585 no 2332 0.301647441509249 3268 1045166 SGTC_1039 k821-0043 94 µM -0.522574142755325 0.308230314586575 no 2333 0.300635319179941 3415 15992768 SGTC_492 tmb-8 126 µM -0.523307575915516 0.307955076250697 no 2334 0.30038011489336 3327 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1759 st043059 70 µM -0.523934170845606 0.30772001705197 no 2335 0.300162163443103 3290 669426 SGTC_1886 st057356 49.9 µM -0.523966622847266 0.307707845240428 no 2336 0.300150877459313 3277 24207747 SGTC_1003 4049-0218 100 µM -0.525056879740087 0.30729904433233 no 2337 0.299771825318163 3463 295161 SGTC_220 paclitaxel 373.376 µM -0.52524410835947 0.307228865464971 no 2338 0.299706752925807 3386 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2592 piperlongumine 83.33 µM -0.525553855292931 0.307112778581901 no 2339 0.299599112633736 3328 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1057 3448-5381 134 µM -0.526313464737892 0.306828174178754 no 2340 0.299335214609941 3390 5497911 SGTC_872 0588-0139 234 µM -0.52815263848903 0.306139569567587 no 2341 0.298696699256602 3383 2047100 SGTC_2360 9040895 200 µM -0.528488159218688 0.306014021075493 no 2342 0.298580281626714 3344 4914414 SGTC_1888 azatryptophan 97.5 µM -0.528758154341173 0.305913008152883 no 2343 0.298486614795478 3383 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3267 9137951 49.47 µM -0.528953959783054 0.305839760952315 no 2344 0.298418694246556 3303 16643986 SGTC_2492 derrusnin 100 µM -0.529588740010247 0.305602354797747 no 2345 0.298198551493406 3356 1715307 Part of coumarin class of compounds. SGTC_1159 4092-0538 61.2 µM -0.530553091212024 0.305241846314989 no 2346 0.297864254634748 3405 717301 SGTC_887 0885-0007 9.62 µM -0.532028543057552 0.304690635964011 no 2347 0.297353113373234 3424 5719458 SGTC_1308 1187-1617 41.4 µM -0.533408780878304 0.304175397447205 no 2348 0.296875320212496 3365 2882570 SGTC_3262 9137218 49.47 µM -0.533797042685186 0.304030530498255 no 2349 0.29674098002431 3318 17650664 SGTC_108 0509-0257 621.132 µM -0.535285515290904 0.303475441763836 no 2350 0.296226220428347 3355 536624 SGTC_2238 6671620 73.2395 µM -0.535531410455809 0.303383784882026 no 2351 0.296141221755728 3379 729941 SGTC_236 1509-0011 5.31 µM -0.5358149976979 0.303278093723456 no 2352 0.296043207946259 3501 3107280 SGTC_2840 9008771 71.43 µM -0.535841939776572 0.303268053438553 no 2353 0.296033896962802 3353 2992978 SGTC_989 1501-0895 10.3 µM -0.536694499228398 0.30295041383605 no 2354 0.295739328163855 3457 2830112 SGTC_58 0957-0393 9 µM -0.537148154626872 0.302781455350463 no 2355 0.295582640083366 3431 6997992 SGTC_3291 9121177 71.43 µM -0.537824235030915 0.302529735694243 no 2356 0.295349199459258 3346 17015612 SGTC_3069 9117009 49.47 µM -0.538865151872395 0.302142362898612 no 2357 0.294989952122221 3315 41904981 SGTC_2905 7799065 20.05 µM -0.541042954826647 0.301332623932322 no 2358 0.294238987933849 3427 1296806 SGTC_1157 4092-0394 27.6 µM -0.54150750426925 0.301160024182388 no 2359 0.29407891332392 3521 3659885 SGTC_10 0279-0212 42.575 µM -0.542363345488758 0.300842159681049 no 2360 0.293784112690022 3414 39851 YBR002C RER2 SGTC_705 1124-0212 310 µM -0.543261092776625 0.300508893744652 no 2361 0.293475024233635 3459 9554485 SGTC_2129 girgensonine 121.053 µM -0.543677533248223 0.300354357401078 no 2362 0.293331697691181 3362 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1498 4478-3555 97.6 µM -0.545177404384564 0.299798070035094 no 2363 0.29281575523474 3430 3437919 SGTC_2338 7999974 200 µM -0.545554474106261 0.299658292024933 no 2364 0.29268611287669 3449 315925 SGTC_1182 1222-0449 220 µM -0.545586681460702 0.299646354275621 no 2365 0.292675040729813 3407 658318 SGTC_2299 7976368 114.88 µM -0.545946116687235 0.299513143189081 no 2366 0.292551488378167 3409 2979718 SGTC_3032 9089427 49.47 µM -0.546202873630178 0.299418002368294 no 2367 0.292463245527715 3422 17173707 SGTC_2148 5546263 113.568 µM -0.546301963568607 0.29938128843598 no 2368 0.292429193365872 3336 792097 SGTC_1653 st012112 65 µM -0.546671596458562 0.299244353324347 no 2369 0.292302185644068 3461 720429 SGTC_926 2268-1401 59.4 µM -0.546917327979461 0.299153334748165 no 2370 0.292217765256224 3440 2931578 SGTC_17 0960-0276 49.807 µM -0.547952741242282 0.298769957363976 no 2371 0.291862176533164 3421 6821114 SGTC_2878 9043973 25.97 µM -0.548911395848719 0.298415200248199 no 2372 0.291533128603509 3474 6465167 SGTC_3148 9097893 49.47 µM -0.549499135799793 0.298197797637182 no 2373 0.291331478741959 3313 17174100 SGTC_767 0929-0023 86 µM -0.55135745551346 0.297510887838891 no 2374 0.29069432964405 3485 1204563 SGTC_1439 4092-1168 46 µM -0.551887791424273 0.297314986920402 no 2375 0.29051261668408 3414 2886240 SGTC_2760 etidronate 98.04 µM -0.55220630018532 0.297197361222058 no 2376 0.290403509201476 3367 3305 A chelator and antioxidant. SGTC_2241 6772625 37.8075 µM -0.55341831465409 0.296749957309299 no 2377 0.289988500368136 3428 2285411 SGTC_513 4245-1575 41.7 µM -0.553436702362116 0.2967431720324 no 2378 0.289982206329969 3383 719745 SGTC_2193 5925765 200 µM -0.553995912817952 0.296536850845838 no 2379 0.289790821451371 3452 877370 SGTC_123 0083-0120 66.675 µM -0.554730243703758 0.296266018693192 no 2380 0.289539593182118 3380 16001701 SGTC_186 3455-3465 67.277 µM -0.555508991159804 0.295978929055936 no 2381 0.289273280967976 3411 755278 SGTC_2762 leflunomide 42.06 µM -0.555908398176475 0.295831734976736 no 2382 0.289136738406134 3437 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1883 5-benzylidenerhodanine 20 µM -0.556510256488386 0.29560999474353 no 2383 0.288931042456915 3435 1273210 SGTC_759 3486-0358 89.3 µM -0.558289626572764 0.294954875875639 no 2384 0.2883233136605 3501 875103 SGTC_373 0844-0104 25.9 µM -0.55877724199798 0.294775465111414 no 2385 0.288156878019617 3457 5375804 SGTC_3246 9135460 32.98 µM -0.559450709769888 0.294527755541705 no 2386 0.287927080774345 3405 41446951 SGTC_3232 9132874 49.47 µM -0.562969052575864 0.293235231152742 no 2387 0.286727978786605 3401 3784940 SGTC_1505 k297-0037 20.6 µM -0.563273056484706 0.293123673558396 no 2388 0.286624481089476 3366 4089396 SGTC_2347 9049783 174.81 µM -0.565129863158927 0.292442725457438 no 2389 0.285992718815468 3481 6467988 YPL169C MEX67 SGTC_67 0335-0847 266 µM -0.565340756439511 0.29236543093411 no 2390 0.28592100608999 3568 4552207 YOR254C SEC63 SGTC_531 3788-1495 174 µM -0.565630680661692 0.292259186279429 no 2391 0.285822433424049 3403 2896655 SGTC_1900 st060200 72.8 µM -0.567752891341622 0.291482035533013 no 2392 0.285101385829366 3435 688945 SGTC_3146 9095609 49.47 µM -0.567967177001694 0.2914036180143 no 2393 0.285028627823859 3413 17173999 SGTC_1677 st019204 53.9 µM -0.568879298017239 0.291069938850872 no 2394 0.284719027673115 3428 3945625 SGTC_392 N-ethylmaleimide 8.33 µM -0.570232012017944 0.290575407427511 no 2395 0.284260173333212 3393 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_847 0342-0274 5.54 µM -0.570489123084725 0.290481456059186 no 2396 0.284172998643391 3467 18097 SGTC_732 3970-1727 52.7 µM -0.570780893139085 0.290374857119811 no 2397 0.284074088151869 3482 1275699 SGTC_2487 5918373 44.05 µM -0.571916820128469 0.289960017841318 no 2398 0.283689164118112 3537 2876279 SGTC_201 4262-0159 12.803 µM -0.572554186423692 0.289727374147715 no 2399 0.283473293499166 3423 1341029 SGTC_2286 7945697 125 µM -0.572671739736004 0.289684475836547 no 2400 0.283433487779342 3424 1245733 SGTC_2714 st079313 56.9 µM -0.573561472950973 0.289359885376582 no 2401 0.283132294620777 3463 2939799 SGTC_1180 1193-0155 285 µM -0.573609756578785 0.289342275542241 no 2402 0.283115954005024 3482 2921347 SGTC_493 zm226600 134 µM -0.576754735732477 0.288196336016838 no 2403 0.282052575461542 3526 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1483 3453-0561 55.9 µM -0.578217662703592 0.287664018272114 no 2404 0.281558587703902 3481 4546991 SGTC_2331 7980721 200 µM -0.578555447248033 0.287541174094102 no 2405 0.281444587047089 3407 2981221 SGTC_1845 st056753 3.01 µM -0.578853162536445 0.287432922716173 no 2406 0.281344128040476 3392 5375839 SGTC_1611 st001856 99.4 µM -0.579583134495667 0.287167581366463 no 2407 0.281097884575475 3430 647478 SGTC_2620 irigenin 100 µM -0.579841499437529 0.287073694725282 no 2408 0.281010754565692 3516 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_69 0096-0274 206.684 µM -0.580964872743301 0.286665643777611 no 2409 0.280632064227862 3633 6741392 SGTC_1978 st071761 42 µM -0.581612345787259 0.286430582509655 no 2410 0.280413912593087 3408 5147680 SGTC_387 norethindrone acetate 66.7 µM -0.582368154019549 0.286156306556394 no 2411 0.280159363731375 3439 541197 SGTC_1215 3852-0577 11.2 µM -0.582464930799274 0.286121196152481 no 2412 0.280126778341038 3534 2884876 SGTC_2486 5283202 22.39 µM -0.583033692479829 0.285914892027995 no 2413 0.279935309595795 3421 1377751 SGTC_1302 1159-0335 255 µM -0.58405908257602 0.285543136098703 no 2414 0.279590281225799 3463 649284 SGTC_2743 auranofin 4.32 µM -0.584350616136466 0.285437482415557 no 2415 0.279492222264781 3428 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_645 0845-0943 5.41 µM -0.587961949259011 0.284130257438924 no 2416 0.278278916700158 3453 1885106 SGTC_2886 9058944 51.95 µM -0.59018862976151 0.283325676467942 no 2417 0.277532097086384 3339 4949929 SGTC_1345 1488-0192 31.4 µM -0.590339038218574 0.283271367816589 no 2418 0.277481686035746 3534 658348 SGTC_2898 9056270 58.44 µM -0.592162199362463 0.282613468274004 no 2419 0.276870989666322 3451 19154699 SGTC_2580 diallyl disulphide 81.36 µM -0.592614852019068 0.282450239504742 no 2420 0.276719468633249 3458 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_563 tetrahydrosecaminediol 614 µM -0.593029462282626 0.282300768804178 no 2421 0.276580717577421 3542 334274 A psychoactive constituent of the cannabis plant. SGTC_2235 salicylic acid 500 µM -0.593039794957189 0.28229704426889 no 2422 0.276577260140317 3488 338 A COX inhibitor and kinase inhibitor. SGTC_433 pimozide 108 µM -0.593311747077479 0.282199024398226 no 2423 0.276486269309646 3382 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1465 k213-0056 144 µM -0.593337916900347 0.282189592856921 no 2424 0.276477514079641 3424 24048857 YMR208W ERG12 SGTC_2972 9093619 59.92 µM -0.594348804926825 0.281825387416134 no 2425 0.276139421105779 3401 25236256 SGTC_1863 st057641 20.1 µM -0.594421957913903 0.281799040454343 no 2426 0.276114962859323 3520 3921635 SGTC_2673 kobusone 100 µM -0.594956703522388 0.28160648120995 no 2427 0.275936206296729 3552 6710676 An epoxy ketone and protein crosslinker. SGTC_2485 5633444 17.78 µM -0.595175566475422 0.281527688049528 no 2428 0.275863060449028 3474 5724239 SGTC_3288 9119690 36.221 µM -0.595751749537579 0.281320306439292 no 2429 0.275670540765554 3458 17595618 YKL019W RAM2 SGTC_764 1951-2361 146 µM -0.597596898780073 0.28065669118333 no 2430 0.275054467006968 3410 5438930 SGTC_48 0382-0018 55 µM -0.597681108088258 0.280626423049661 no 2431 0.275026366693238 3646 762596 SGTC_2618 avocadyne 43.43 µM -0.5978779510904 0.280555676102691 no 2432 0.274960686477466 3464 3015189 SGTC_745 0469-0705 296 µM -0.598499026844814 0.280332513111835 no 2433 0.274753504031908 3613 3486736 SGTC_1088 bifonazole 369 nM -0.600819668200821 0.279499429068763 no 2434 0.273980051322597 3479 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2250 alverine citrate 130 µM -0.601173536733595 0.279372499976551 no 2435 0.27386220416937 3476 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_656 4090-1979 187 µM -0.601362337144518 0.279304790620921 no 2436 0.273799339121592 3552 22330961 SGTC_152 4469-0003 551.229 µM -0.602599052620402 0.278861465527257 no 2437 0.273387725382887 3535 697280 SGTC_3219 9131112 49.47 µM -0.60364728988972 0.278485972472571 no 2438 0.273039082584031 3470 17612988 YMR079W SEC14 SGTC_2092 5303694 80.6725 µM -0.603815329533956 0.278425801270084 no 2439 0.272983213249742 3488 1963699 SGTC_3193 9111931 49.47 µM -0.604927589204829 0.278027686014866 no 2440 0.272613555355358 3501 17087244 SGTC_1879 gemcitabine 100 µM -0.605181077331878 0.277936992941458 no 2441 0.272529343721771 3510 60750 A nucleoside analog which inhibits DNA replication. SGTC_1539 benzyladenosine 56 µM -0.605401287788642 0.277858217686528 no 2442 0.272456197793117 3483 92208 A nucleotide analog. SGTC_1352 1496-0991 99 µM -0.605508001564512 0.277820047194799 no 2443 0.272420754853751 3496 3000039 SGTC_175 3793-3120 23.7 µM -0.605588634228111 0.277791207364335 no 2444 0.272393975775859 3468 5322297 SGTC_38 0929-0051 58.268 µM -0.606336124327964 0.277523922694713 no 2445 0.272145787580572 3497 1379719 SGTC_2385 9074692 200 µM -0.609301911415382 0.276464668097358 no 2446 0.271162170188582 3486 17046906 SGTC_2694 st077685 81.9 µM -0.610620786485031 0.275994258978667 no 2447 0.270725329125042 3494 2838096 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.611185772869728 0.275792863068478 no 2448 0.270538300499506 3497 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1520 flindersine 88 µM -0.611652065680411 0.275626702035881 no 2449 0.270383991250451 3608 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_156 3474-0145 5.642 µM -0.611882082721789 0.275544754784854 no 2450 0.270307888425327 3516 2265471 SGTC_1470 k295-0292 231 µM -0.612140100729948 0.27545284600269 no 2451 0.270222534020371 3551 5045612 SGTC_2803 7707263 71.43 µM -0.613566670876127 0.274944958786742 no 2452 0.269750856694263 3480 2199229 SGTC_1830 st055982 50.3 µM -0.61529876708863 0.274328919139361 no 2453 0.269178715820748 3524 455313 An antimicrobial agent. SGTC_1384 3089-0840 101 µM -0.616689498090956 0.27383478362511 no 2454 0.268719774748033 3524 1069836 SGTC_3280 9140961 49.47 µM -0.617046581077727 0.2737079808282 no 2455 0.268602000859765 3483 4901226 SGTC_990 3985-0011 41.3 µM -0.618107100448104 0.273331553911572 no 2456 0.268252371052974 3489 5399565 YGL099W LSG1 SGTC_1186 1319-0216 26 µM -0.619021259501569 0.273007282864235 no 2457 0.267951176865349 3595 4565136 SGTC_3302 9125395 16.351 µM -0.622889285640463 0.271637328654496 no 2458 0.266678639676813 3489 17599668 SGTC_2708 st078559 56 µM -0.623076021891688 0.271571278240554 no 2459 0.266617282940132 3503 17250902 SGTC_676 falcarinol 140 µM -0.62481115024384 0.270957929287104 no 2460 0.266047505824746 3621 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1209 2323-2347 50.3 µM -0.625031099957368 0.270880228849335 no 2461 0.265975323355757 3543 5412760 SGTC_447 ml7 120 µM -0.625064561946546 0.270868408889204 no 2462 0.265964342765254 3577 4216 Selective myosin light chain kinase inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.625083301350826 0.27086178958012 no 2463 0.26595819350836 3615 1377 SGTC_229 benomyl 22.8748 µM -0.626053188670982 0.270519307092538 no 2464 0.265640027422722 3564 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2588 indole-3-carbinol 100 µM -0.627752506154572 0.269919773404408 no 2465 0.265083041607674 3556 3712 Induces cell cycle arrest. SGTC_2572 astragaloside iv 100 µM -0.629841470877165 0.269183681285563 no 2466 0.264399154809164 3577 45006101 An anti-inflammatory agent. SGTC_737 1950-0117 57.9 µM -0.629967019410966 0.269139473633183 no 2467 0.264358081266037 3551 5393513 SGTC_2098 5376439 882.5 nM -0.630613997045016 0.268911720200142 no 2468 0.264146472289961 3599 2844116 SGTC_1025 k007-0731 70 µM -0.633158671686879 0.268016866495539 no 2469 0.263315015597494 3521 6256118 SGTC_1203 3992-3522 103 µM -0.633491757164469 0.26789984557841 no 2470 0.2632062809816 3717 5322312 SGTC_918 glabranin 770.725 nM -0.633496507071837 0.267898177008145 no 2471 0.263204730556463 3576 124049 Also referred to as licorice root. SGTC_2474 5321570 43.32 µM -0.634257050022982 0.267631077361508 no 2472 0.262956540662458 3552 2841384 SGTC_2933 9026794 32.47 µM -0.634299743964222 0.267616087400005 no 2473 0.262942611788578 3539 17586027 SGTC_1579 chlormadinone acetate 49.4 µM -0.637592385837356 0.266461308113765 no 2474 0.261869526718973 3596 45114258 A steroidal progestin. SGTC_2093 5331342 194.4 µM -0.638367874035998 0.266189699883718 no 2475 0.261617119206697 3591 33839 SGTC_1321 1326-2144 215 µM -0.639086433060184 0.265938155786419 no 2476 0.261383352621809 3544 3513030 SGTC_2997 9067075 71.4286 µM -0.640486395746126 0.265448420611683 no 2477 0.260928215403184 3547 27209819 SGTC_3283 9109332 35.8195 µM -0.640551035363356 0.265425819427495 no 2478 0.260907210480015 3477 17027281 SGTC_1851 st056236 18.9 µM -0.641589282313512 0.265062931167488 no 2479 0.260569946849445 3618 5393171 SGTC_3045 9092950 49.47 µM -0.64173101985522 0.265013410595658 no 2480 0.260523922313651 3612 44120432 SGTC_121 0557-0495 61.343 µM -0.641967738524431 0.264930715792185 no 2481 0.26044706516097 3693 3104427 SGTC_3044 9093193 49.47 µM -0.642067670191501 0.264895809810068 no 2482 0.260414623133599 3558 25236277 SGTC_1383 3049-0032 20.7 µM -0.643022371786652 0.264562451845983 no 2483 0.260104791752257 3608 712864 SGTC_2277 7947813 106.88 µM -0.64466821221349 0.263988267005987 no 2484 0.259571110128368 3648 1246798 SGTC_360 0957-0399 1.01 µM -0.64582094268646 0.263586492096148 no 2485 0.259197661713011 3587 6752301 YPR165W RHO1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.646337394964694 0.263406588079886 no 2486 0.259030437550321 3564 17037758 SGTC_3130 9127414 49.47 µM -0.646512533662149 0.263345593475208 no 2487 0.258973741357316 3599 1494646 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.647066719683421 0.26315263764028 no 2488 0.258794381626661 3613 279621 SGTC_1919 st067113 52.3 µM -0.647608237151172 0.262964162526215 no 2489 0.258619184132053 3581 1268243 SGTC_1224 0823-0416 294 µM -0.648313028054012 0.262718963498222 no 2490 0.258391254686625 3617 3598164 SGTC_2616 abietic acid 100 µM -0.649564470064142 0.262283871189604 no 2491 0.257986794845004 3616 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1211 1056-0033 32.3 µM -0.650402625597834 0.261992673853286 no 2492 0.257716090884263 3606 6741922 SGTC_902 1120-0002 2.07 µM -0.651894048561858 0.261474924356124 no 2493 0.257234762240631 3597 3280475 SGTC_2174 5790901 200 µM -0.652496384215022 0.261265971750476 no 2494 0.257040502329346 3591 786020 SGTC_3309 9129340 25.759 µM -0.653045615016308 0.261075516231758 no 2495 0.25686343585438 3612 17158987 SGTC_1864 st057645 30.4 µM -0.653519090556437 0.260911387494743 no 2496 0.256710843075233 3636 688666 SGTC_3266 9136860 49.47 µM -0.653657837619343 0.260863301338044 no 2497 0.256666136297811 3538 4871271 YPR165W RHO1 SGTC_2794 7785382 27.27 µM -0.65480067266876 0.260467397644685 no 2498 0.256298048748289 3590 2205081 SGTC_1578 josamycin 24.2 µM -0.65489539316073 0.260434598232933 no 2499 0.25626755325662 3534 5282165 A P450 substrate. SGTC_1221 2958-7315 257 µM -0.65495441051225 0.260414163029459 no 2500 0.256248553433922 3602 4562705 SGTC_14 0354-0009 295 µM -0.655246992946944 0.260312866350337 no 2501 0.25615437139865 3625 1713507 SGTC_917 harmaline 728.087 nM -0.656544182899868 0.259864003266404 no 2502 0.255737024592775 3578 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_836 0330-0104 1.35 µM -0.657118261933198 0.259665483804346 no 2503 0.255552438698424 3620 46494820 SGTC_588 3970-1144 52.9 µM -0.657153923714876 0.25965315436111 no 2504 0.255540974521555 3547 1888707 SGTC_1621 st003705 32.4 µM -0.658209904852277 0.259288204185308 no 2505 0.255201630538554 3640 24207032 SGTC_3108 9121785 49.47 µM -0.658308193306533 0.259254248896776 no 2506 0.255170057121161 3565 17140271 SGTC_2537 larixol 68.93 µM -0.659708670206075 0.258770681953438 no 2507 0.254720400843208 3616 6708759 SGTC_348 k064-0012 10.7 µM -0.660038377651929 0.258656906068653 no 2508 0.254614600827912 3550 5066323 SGTC_1560 lithocholic acid 53.1 µM -0.660665741639403 0.258440486013154 no 2509 0.25441334921501 3567 9903 A bile acid which acts as a detergent. SGTC_543 3844-1095 191 µM -0.661063017724883 0.258303487283315 no 2510 0.254285950447701 3611 4230703 SGTC_2575 plumbagin 510 nM -0.6624310208268 0.257832026148055 no 2511 0.253847514280737 3581 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2669 eugenol 100 µM -0.664663081950073 0.257063740606531 no 2512 0.253133005909149 3592 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1771 st048882 4.1505 µM -0.665957646711255 0.256618691735295 no 2513 0.252719086076834 3585 4580403 SGTC_903 1134-0042 114 µM -0.666646006081085 0.256382209254947 no 2514 0.252499137575233 3615 701009 SGTC_805 3852-0218 479 µM -0.66742578913755 0.256114455874654 no 2515 0.252250098763024 3593 6615355 SGTC_1424 4048-1941 275 µM -0.667709172563433 0.256017186913936 no 2516 0.252159626878281 3676 X1424 SGTC_2312 7706453 155.7 µM -0.670030457742426 0.255221151489987 no 2517 0.2514191871807 3654 976098 SGTC_1247 0448-0043 5.84 µM -0.672931656192421 0.254228069667002 no 2518 0.250495385831476 3661 3089013 YGL099W LSG1 SGTC_3071 9117417 49.47 µM -0.673529473244959 0.254023688622711 no 2519 0.250305252316276 3562 45595590 YGL055W OLE1 SGTC_3347 9188721 44.724 µM -0.67399684391898 0.253863964506745 no 2520 0.250156660101233 3626 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1738 st035555 74 µM -0.674052011521249 0.25384511443553 no 2521 0.250139123628509 3643 5331140 SGTC_1511 0906-3109 28.5 µM -0.674145848635867 0.25381305316932 no 2522 0.250109296532608 3680 2882180 SGTC_3242 9133940 49.47 µM -0.67415747448186 0.253809081122054 no 2523 0.250105601268763 3673 17248444 SGTC_2343 7990716 14.84 µM -0.674432933686177 0.253714978208171 no 2524 0.250018055301737 3615 6456862 SGTC_1317 1273-0028 910 nM -0.675918636865802 0.25320774543639 no 2525 0.249546152183269 3621 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2168 5727979 200 µM -0.676927231065026 0.252863706208307 no 2526 0.249226062822467 3583 695210 SGTC_1283 0922-0125 16.4 µM -0.677935995369525 0.252519855236622 no 2527 0.248906137996781 3639 3360884 SGTC_1207 2099-0101 141 µM -0.679096820633101 0.252124477306759 no 2528 0.2485382584214 3660 5837381 SGTC_2569 tetrandrine 100 µM -0.680068303939522 0.25179384054857 no 2529 0.248230606412952 3624 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2149 5554786 194.827 µM -0.680447370141264 0.251664890444489 no 2530 0.248110617785656 3679 745063 YPR165W RHO1 SGTC_2839 9003951 25.97 µM -0.681237427225776 0.251396242297895 no 2531 0.247860634647391 3624 2990634 SGTC_2219 9098279 200 µM -0.681522057688421 0.251299494741995 no 2532 0.247770607253111 3638 902349 SGTC_213 1246-0773 967 nM -0.681697499959036 0.251239870697742 no 2533 0.247715124314158 3615 6251622 SGTC_2867 9039098 71.43 µM -0.682228632991752 0.251059410784887 no 2534 0.247547196002708 3631 6463460 SGTC_1473 k844-0725 134 µM -0.682249704153321 0.251052252976129 no 2535 0.247540535188833 3716 54682906 SGTC_1968 st069590 43.6 µM -0.68465196407128 0.250236920996411 no 2536 0.246781783913584 3602 6384066 SGTC_2302 7771753 200 µM -0.684857309047113 0.250167291688507 no 2537 0.246716983733433 3638 2203047 SGTC_354 2783-3500 4.88 µM -0.685037259549775 0.25010628170341 no 2538 0.246660204712779 3634 6740761 SGTC_2182 6325192 200 µM -0.685666224503503 0.249893100960576 no 2539 0.2464618050509 3606 736248 SGTC_1341 1486-1360 280 µM -0.687000939934048 0.249441033560138 no 2540 0.246041068056547 3655 3976547 SGTC_3112 9123419 49.47 µM -0.688088104093691 0.249073133082086 no 2541 0.245698650608003 3695 17015854 SGTC_306 1672-3436 11.6 µM -0.689997457542493 0.248427699970764 no 2542 0.245097893104137 3677 6797378 SGTC_21 0849-0113 22.993 µM -0.691027588886106 0.248079847471342 no 2543 0.244774101774988 3638 1560156 SGTC_1145 3546-0597 10.2 µM -0.691884618624255 0.247790645673615 no 2544 0.244504895394973 3628 875334 SGTC_1067 clotrimazole 1.36 µM -0.692247508609919 0.247668243936283 no 2545 0.244390954088049 3691 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_968 1309-0633 340 µM -0.692271665857095 0.24766009691355 no 2546 0.244383370137657 3633 3761976 SGTC_2881 9058953 51.95 µM -0.692880921968345 0.247454672848454 no 2547 0.24419214160468 3643 17122249 SGTC_1140 3229-1848 2.98 µM -0.693106537109383 0.247378624862699 no 2548 0.244121347768096 3662 2849525 SGTC_2197 6588183 93.1375 µM -0.6934159217363 0.247274361050654 no 2549 0.244024286622317 3633 884136 SGTC_3127 9126946 49.47 µM -0.69542568771697 0.246597634585983 no 2550 0.243394283472311 3620 27243249 SGTC_3310 9130229 44.1445 µM -0.695645335409355 0.246523735207954 no 2551 0.243325483626327 3700 7761258 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.696271954398041 0.246312977575735 no 2552 0.243129266678644 3712 6708561 SGTC_1710 st031758 61.5 µM -0.696390789336964 0.246273019416781 no 2553 0.243092064838023 3688 5394341 SGTC_3296 9122258 64.045 µM -0.697065926940813 0.246046070877887 no 2554 0.242880768248898 3686 4730474 SGTC_2571 chrysanthemic acid 100 µM -0.69792715825936 0.245756729574928 no 2555 0.242611374551578 3641 2743 An insecticide. SGTC_553 k007-0256 45.7 µM -0.69852221600258 0.245556919337809 no 2556 0.242425334673195 3703 6287000 SGTC_77 0828-0286 12.516 µM -0.699862443367086 0.245107213652151 no 2557 0.242006606890637 3647 745345 SGTC_1232 0279-0259 161 µM -0.700069783336546 0.245037681487487 no 2558 0.241941862633968 3707 1560000 SGTC_333 3486-0131 40.1 µM -0.70028552401351 0.244965343382805 no 2559 0.241874505137064 3739 6744690 SGTC_3091 9116372 49.47 µM -0.703193085839014 0.243991556321257 no 2560 0.240967713759196 3695 17169793 SGTC_561 1550-0330 72.9 µM -0.703544151603504 0.243874120467939 no 2561 0.240858350901142 3647 6812934 SGTC_786 4544-0069 423 µM -0.703692767333731 0.243824415853361 no 2562 0.240812062751507 3710 748821 YLR208W SEC13 SGTC_1006 4099-6547 255 µM -0.704297821407096 0.243622111632668 no 2563 0.240623661387258 3689 3146833 SGTC_1068 loratadine 26.9 µM -0.704777633890721 0.243461747309864 no 2564 0.24047431473551 3695 3957 A H1 histamine antagonist. SGTC_1175 0741-0056 27.6 µM -0.705460251202485 0.243233699281299 no 2565 0.240261929984485 3744 765927 SGTC_809 3998-0021 90 µM -0.706371122579544 0.242929576323151 no 2566 0.239978687130907 3614 715485 SGTC_401 neomycin 50 µM -0.707716641019312 0.242480709476293 no 2567 0.239560620602587 3675 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1503 4585-0012 61.3 µM -0.708855394138999 0.242101171113122 no 2568 0.23920710907783 3691 2922052 SGTC_1602 st001878 87.6 µM -0.709130815135525 0.242009423641642 no 2569 0.239121650936796 3705 595405 YLR310C CDC25 SGTC_400 oxethazaine 37.5 µM -0.709548283199065 0.241870393809829 no 2570 0.238992149987442 3688 4621 A local anesthetic. SGTC_2568 diosmetin 100 µM -0.710337261413303 0.241607757940459 no 2571 0.238747509241198 3673 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3099 9120367 49.47 µM -0.711219466088702 0.241314272211197 no 2572 0.238474123820511 3724 24824940 SGTC_288 1315-0019 35.1 µM -0.712951904364062 0.240738500820335 no 2573 0.237937759572996 3752 6811474 SGTC_1274 0865-0114 173 µM -0.713312581321396 0.240618724859553 no 2574 0.237826176945646 3706 870624 SGTC_1790 st045711 43.5 µM -0.713728121665981 0.24048076973488 no 2575 0.237697656818221 3710 585119 SGTC_200 k038-0079 37.545 µM -0.714525690498188 0.240216105796879 no 2576 0.237451088039505 3659 3436683 SGTC_2860 9025725 38.96 µM -0.714539416786846 0.240211552277554 no 2577 0.237446845780311 3693 40546248 SGTC_1988 st071872 53.4 µM -0.714548121558403 0.240208664606173 no 2578 0.237444155497297 3698 16414116 SGTC_2663 amphotericin b 100 µM -0.71565967516346 0.239840079630033 no 2579 0.237100758017719 3693 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.716249508398344 0.239644619584277 no 2580 0.23691864894373 3726 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2741 miltefosine 3.04 µM -0.717717422920277 0.239158556956774 no 2581 0.236465769139222 3639 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2772 vinpocetine 57.06 µM -0.718037197317277 0.239052743296446 no 2582 0.236367175841357 3715 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2811 7967822 32.47 µM -0.719345016088002 0.2386202512759 no 2583 0.235964182940183 3736 2232244 SGTC_2792 7535235 81.82 µM -0.719556015332892 0.238550514553266 no 2584 0.235899200862861 3701 1281891 SGTC_1158 4092-0494 91.8 µM -0.719809852991568 0.238466634221281 no 2585 0.23582103878233 3824 1148199 SGTC_675 1309-0189 238 µM -0.720284239265665 0.238309917177732 no 2586 0.235675003317495 3720 4246530 SGTC_1940 st075990 51.1 µM -0.721149637011976 0.238024171955158 no 2587 0.235408727089011 3793 1084979 SGTC_938 3126-1755 342 µM -0.721196940252985 0.238008558338289 no 2588 0.235394177033278 3700 1777771 SGTC_1422 4031-0024 15.5 µM -0.722096930396599 0.237711601080893 no 2589 0.23511744265783 3664 782427 SGTC_2048 5246248 200 µM -0.722167095142032 0.237688458337477 no 2590 0.235095875533622 3691 677046 SGTC_1034 k072-0165 12.7 µM -0.722681806273309 0.237518726723427 no 2591 0.234937697886359 3700 5835461 SGTC_1634 st006576 41 µM -0.723495004648636 0.237250701315403 no 2592 0.234687910995825 3688 3915356 SGTC_2381 9035592 200 µM -0.725144788896249 0.236707452861556 no 2593 0.234181604830673 3710 4749657 SGTC_235 0330-0087 5 mM -0.726014374296866 0.236421387422807 no 2594 0.233914979308749 3745 46494818 YHR062C RPP1 SGTC_258 haloperidol 50.781 µM -0.726204052345259 0.236359014778043 no 2595 0.233856844051101 3738 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3109 9122853 49.47 µM -0.726355930697266 0.236309078501081 no 2596 0.233810299960981 3771 1234709 SGTC_2167 5876490 200 µM -0.728546635262241 0.235589440525804 no 2597 0.233139515960456 3847 686534 SGTC_2401 5128683 200 µM -0.729737619957097 0.235198714519418 no 2598 0.232775290513168 3687 708373 SGTC_3225 9130819 49.47 µM -0.730001228058203 0.235112281078045 no 2599 0.232694716972818 3708 4547121 SGTC_2440 5628896 157.78 µM -0.730785447318973 0.234855250216996 no 2600 0.232455106903337 3764 5522048 SGTC_597 k018-0003 82.8 µM -0.731528592082349 0.234611825065442 no 2601 0.232228173403024 3814 6786234 SGTC_3134 9127454 49.47 µM -0.733200219939126 0.234064775483278 no 2602 0.23171816061682 3808 24262820 SGTC_120 rhodamine 6G 52.259 µM -0.733834145989528 0.233857504531998 no 2603 0.23152491344779 3764 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_90 0870-0863 4.608 µM -0.734113515798146 0.233766192980122 no 2604 0.231439778377616 3714 1738164 SGTC_2478 5763493 32.33 µM -0.735400761481339 0.233345714299631 no 2605 0.231047729118053 3693 1365576 YLR208W SEC13 SGTC_3129 9127257 49.47 µM -0.737950713446519 0.232514013134479 no 2606 0.23027219996647 3724 837894 SGTC_1061 3448-9325 110 µM -0.738552959334962 0.232317823433703 no 2607 0.230089248778029 3675 723482 SGTC_1254 0550-0035 264 µM -0.740363542262999 0.231728556682354 no 2608 0.22953971717493 3803 15121435 SGTC_59 0330-0160 1.33 µM -0.741595028106796 0.231328237408808 no 2609 0.229166368409714 3722 4293482 SGTC_1935 st074532 41.6 µM -0.742084720042921 0.231169160432632 no 2610 0.229018003513471 3782 2829742 SGTC_721 1187-1332 279 µM -0.742334532410221 0.231088032121653 no 2611 0.228942337128476 3674 25730 SGTC_3093 9117344 49.47 µM -0.742822277228642 0.23092967939363 no 2612 0.228794643141934 3780 24824913 SGTC_3039 9090270 49.47 µM -0.74336363042745 0.230753992964773 no 2613 0.22863077864944 3718 17173750 SGTC_162 k030-0015 37.8 µM -0.744802757115264 0.230287313554561 no 2614 0.228195483950538 3797 1809920 YMR134W ERG29 SGTC_483 fpl-64176 144 µM -0.746261429860439 0.22981483485735 no 2615 0.227754753000434 3774 3423 SGTC_1778 st046819 58.9 µM -0.746340498475499 0.229789239259021 no 2616 0.227730876495394 3794 671715 SGTC_619 1652-1634 108 µM -0.746582066787008 0.229711050162594 no 2617 0.22765793836602 3720 5400454 SGTC_1010 4112-3296 15.2 µM -0.747283135295264 0.229484217733137 no 2618 0.227446335146693 3773 704384 SGTC_875 0709-0210 25.7 µM -0.747587300099586 0.229385843523003 no 2619 0.227354563679286 3747 6251364 SGTC_345 1362-0200 395 µM -0.747886831957736 0.229288990823404 no 2620 0.227264210438267 3748 1419823 SGTC_294 k038-0071 157 µM -0.749639954764852 0.228722584012807 no 2621 0.226735790112372 3764 24152826 SGTC_33 0986-0033 35.816 µM -0.750153116507312 0.228556938157974 no 2622 0.226581245912639 3685 2848082 SGTC_1895 st058434 18.3 µM -0.751214642544763 0.22821449721096 no 2623 0.226261744686154 3746 5393175 SGTC_1454 4239-0054 42.6 µM -0.751449368755206 0.228138815121509 no 2624 0.226191130479798 3873 1340767 SGTC_923 1900-2434 73.3 µM -0.751517645351297 0.228116803546989 no 2625 0.226170592727244 3739 5910570 SGTC_2223 6903751 107.57 µM -0.751879185969554 0.228000266994827 no 2626 0.22606185806687 3710 5598863 SGTC_157 1348-1695 65.819 µM -0.753408641047384 0.227507643463307 no 2627 0.225602195905921 3745 5380510 SGTC_455 paf C-16 10 µM -0.753947355274139 0.227334271382188 no 2628 0.225440416868463 3735 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1977 st070720 65.3 µM -0.756087636550832 0.226646209715696 no 2629 0.224798327040883 3793 682188 SGTC_2406 ethylparaben 405.7 µM -0.758343020913402 0.225922418097923 no 2630 0.22412282948728 3805 8434 A possible steroid mimic. SGTC_488 nitrendipine 139 µM -0.75865063945107 0.225823799405457 no 2631 0.224030785807395 3800 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2111 5486399 200 µM -0.758989103141567 0.225715320275651 no 2632 0.223929537652056 3744 689674 SGTC_1631 benzylvanillin 81.9 µM -0.760541659184735 0.225218097033534 no 2633 0.223465438778566 3826 75506 SGTC_2505 galangin 7.89 µM -0.760784052635717 0.225140523881227 no 2634 0.223393030567027 3690 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3065 9113888 49.47 µM -0.76119311774141 0.225009645149935 no 2635 0.223270864175992 3805 16648368 SGTC_1527 coumarin 137 µM -0.762524800352606 0.224583877453115 no 2636 0.222873423594706 3854 323 A hepatotoxic, DNA x-linker. SGTC_2446 5162541 200 µM -0.762541703165819 0.224578476197708 no 2637 0.222868381543134 3746 1549321 SGTC_2357 9067248 200 µM -0.762622603765902 0.224552625615973 no 2638 0.222844250069753 3784 9150235 SGTC_853 0419-0306 21 µM -0.762678272273148 0.224534838554236 no 2639 0.222827645827686 3782 762713 SGTC_3166 9102297 49.47 µM -0.762803675450966 0.224494772974403 no 2640 0.222790244412637 3756 25237072 SGTC_3076 9116187 49.47 µM -0.762864214095235 0.22447543268462 no 2641 0.222772190082325 3758 27241210 SGTC_422 cantharidin 155 µM -0.763246474613188 0.224353333695573 no 2642 0.222658208475093 3723 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1763 st044482 94.5 µM -0.763313922499037 0.224331793875585 no 2643 0.222638100462459 3806 88505 SGTC_3344 9148862 3.898 µM -0.765217358974626 0.22372440614348 no 2644 0.222071062291688 3779 4905352 SGTC_3215 9129942 49.47 µM -0.768706949257478 0.222613307601056 no 2645 0.221033649288969 3722 17682944 SGTC_2418 pentamidine 31.67 µM -0.769946313007438 0.222219447892443 no 2646 0.220665869952178 3756 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1197 1601-0112 267 µM -0.77063732458966 0.22200002281108 no 2647 0.220460965598914 3784 7350313 SGTC_2374 9071832 200 µM -0.771106272131482 0.221851182839457 no 2648 0.220321971606885 3725 17381698 SGTC_1727 st034309 9.9045 µM -0.77132448472365 0.221781943449653 no 2649 0.220257311484369 3886 870305 SGTC_3178 9107506 49.47 µM -0.77444369838749 0.220793559639891 no 2650 0.219334225292647 3813 8897194 SGTC_1788 fluconazole 20 µM -0.775521917240819 0.220452492461596 no 2651 0.219015659819827 3840 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1379 2144-0755 36.5 µM -0.775886559200484 0.220337215590343 no 2652 0.218907984664691 3855 5392327 SGTC_2074 5212007 75.395 µM -0.775959023062293 0.22031431118803 no 2653 0.218886590432593 3677 758611 SGTC_2692 st077426 47.7 µM -0.777774634012118 0.21974087798026 no 2654 0.218350942191385 3784 25238571 SGTC_2386 9075165 157.42 µM -0.779019214817711 0.21934829149697 no 2655 0.217984197990305 3767 16452277 SGTC_1233 0325-0408 14.2 µM -0.779111628566991 0.219319156891381 no 2656 0.2179569803373 3852 12874 SGTC_3216 9129716 49.47 µM -0.782596005621742 0.218222286668028 no 2657 0.216932193932473 3798 8056934 SGTC_2107 5363541 170.161 µM -0.784121414796848 0.217743089571894 no 2658 0.216484435461606 3763 244052 SGTC_2080 5212524 12.4 µM -0.784312313563409 0.217683162768642 no 2659 0.216428437981551 3743 260183 SGTC_2531 methyl deoxycholate 70.07 µM -0.785144940580593 0.217421896388948 no 2660 0.216184296541415 3784 16667744 Haematoxylin. SGTC_2751 anetholtrithion 17.25 µM -0.785420634782308 0.217335427427657 no 2661 0.216103493126864 3818 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2276 7947513 42.08 µM -0.785984657586936 0.217158588725083 no 2662 0.215938237782047 3690 2105100 SGTC_3319 9138450 16.7555 µM -0.786610942519792 0.216962326337957 no 2663 0.215754825820786 3760 2029690 SGTC_112 phenothiazine 287.218 µM -0.788537166074939 0.216359337913512 no 2664 0.215191283958519 3760 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_246 cycloheximide 667 µM -0.789527360960549 0.216049743426397 no 2665 0.214901922313443 3694 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2281 7943571 200 µM -0.790275509739924 0.215815997395598 no 2666 0.214683443033732 3924 1244024 SGTC_3220 9131269 49.47 µM -0.790931270217571 0.21561123706766 no 2667 0.214492049786651 3857 17722206 SGTC_3324 9138759 60.749 µM -0.792012880551903 0.215273751944533 no 2668 0.21417658291132 3866 45595710 SGTC_1074 carmofur 3.8 µM -0.792479079612983 0.215128382648352 no 2669 0.214040692694626 3845 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.792589275975256 0.215094029759142 no 2670 0.214008579398913 3841 5357218 A potent inhibitor of glutathione S-transferases. SGTC_98 0074-0023 107.663 µM -0.792813651224348 0.215024092303753 no 2671 0.213943200894206 3768 3563821 SGTC_2317 5986382 200 µM -0.793176472605578 0.214911029324039 no 2672 0.213837506534397 3855 877883 SGTC_3114 9122766 49.47 µM -0.793394343896591 0.214843152520024 no 2673 0.213774052544367 3832 17176985 SGTC_2739 tacrine 100.86 µM -0.793752448821956 0.214731613630421 no 2674 0.213669779996042 3842 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2057 5236571 38.335 µM -0.794071165330314 0.21463237135176 no 2675 0.213577001442811 3797 54684039 YBR257W POP4 SGTC_2875 9039966 71.43 µM -0.7951610969315 0.214293188842007 no 2676 0.213259899194206 3879 6463691 SGTC_2921 7974240 10.71 µM -0.795256162040021 0.214263619737467 no 2677 0.21323225418828 3896 2979074 YDR527W RBA50 SGTC_2339 9000433 200 µM -0.797165320627383 0.213670296623372 no 2678 0.212677511970877 3870 2988954 SGTC_748 act1.228 77.9 µM -0.798802663297666 0.213162210980675 no 2679 0.212202423004474 3772 4421505 YNR035C ARC35 SGTC_1431 4049-0260 9.09 µM -0.799607309992912 0.21291277862138 no 2680 0.211969175429057 3805 3854841 SGTC_1170 0310-0127 64.8 µM -0.800392257937428 0.21266961688695 no 2681 0.211741782602974 3852 774975 SGTC_136 0097-0015 404.482 µM -0.80249248101349 0.212019806227145 no 2682 0.211134068035693 3839 4861337 SGTC_150 3970-0969 77.2 µM -0.802724622659447 0.211948052755751 no 2683 0.211066958982852 3929 6615640 SGTC_155 k072-0202 43.6 µM -0.804442987270998 0.21141735931641 no 2684 0.210570591637777 3759 5857737 SGTC_174 3553-0389 74.3 µM -0.808540982245555 0.210154894939493 no 2685 0.209389611894429 3844 738071 SGTC_2246 7293507 91.5585 µM -0.809550034058918 0.20984471833321 no 2686 0.209099417650548 3893 887656 SGTC_2610 ononetin 44.17 µM -0.810124552391918 0.209668235062175 no 2687 0.208934297193656 3860 259632 SGTC_2625 euphol 100 µM -0.813302166964816 0.20869369791632 no 2688 0.20802241747484 3861 6708538 A triterpene alcohol. SGTC_1298 1079-1278 263 µM -0.814853330131702 0.208218945693512 no 2689 0.207578135028151 3879 2840950 SGTC_2034 5197015 53.07 µM -0.815016294773378 0.20816910541519 no 2690 0.207531491445822 3848 780676 SGTC_753 1322-0200 289 µM -0.816136855669695 0.207826589442542 no 2691 0.207210933354065 3895 5403907 SGTC_1306 1185-0270 9.02 µM -0.816913163336479 0.207589494834651 no 2692 0.206989027362166 3883 1548076 SGTC_418 lividomycin a 100 µM -0.817048125402608 0.207548291953306 no 2693 0.206950463079552 3829 72394 An antibiotic. SGTC_1143 3454-2408 5.08 µM -0.818173324963358 0.207204965331006 no 2694 0.206629112239296 3780 X1143 SGTC_575 k072-0246 11.9 µM -0.818402999502023 0.207134927167066 no 2695 0.206563554782222 3887 6796779 SGTC_663 1486-0733 13.9 µM -0.818887372771365 0.206987265747526 no 2696 0.206425337449615 3875 722445 YPR165W RHO1 SGTC_1261 0712-0010 12.7 µM -0.819163912898153 0.206902990299376 no 2697 0.206346450493033 3840 2840123 SGTC_595 3909-8003 73.7 µM -0.820261869995423 0.206568588927988 no 2698 0.206033419130315 3945 699517 SGTC_79 0052-0007 94.094 µM -0.822214663808708 0.205974624225376 no 2699 0.205477367238498 3859 2801472 SGTC_2671 danthron 100 µM -0.822728555392847 0.205818486712355 no 2700 0.205331186468523 3845 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1991 st073000 8.92 µM -0.82597138678223 0.204834826597376 no 2701 0.204410161632965 3953 4301969 YIL048W NEO1 SGTC_830 4076-0286 57.8 µM -0.826152354909329 0.204780015346923 no 2702 0.204358835846731 3928 6866659 SGTC_424 splitomicin 100 mM -0.827114713633054 0.204488684702614 no 2703 0.20408602266923 3973 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_574 1315-0397 40 µM -0.827260733609871 0.204444502277004 no 2704 0.2040446473255 3869 6794277 SGTC_22 0964-0034 14.468 µM -0.828349979026948 0.204115099946413 no 2705 0.203736162993357 3899 138402 SGTC_1956 st077085 54 µM -0.828623051778678 0.204032568695741 no 2706 0.203658869887694 3912 24208685 SGTC_1152 3909-8331 15.9 µM -0.828721703104033 0.204002758024009 no 2707 0.203630950979303 3836 16001939 SGTC_106 0092-0003 11.579 µM -0.82919067979548 0.203861077124716 no 2708 0.203498259019655 3806 1072148 SGTC_2685 mycophenolic acid 18.85 µM -0.829259639588641 0.203840248870892 no 2709 0.203478751931182 3850 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1340 1486-1359 257 µM -0.829566677499879 0.203747528149048 no 2710 0.203391911735261 3806 4309068 SGTC_1820 st053765 18.6 µM -0.829671998419596 0.203715728645391 no 2711 0.20336212868612 3901 3690829 SGTC_509 pifithrin 175 µM -0.829875583122243 0.20365426878509 no 2712 0.203304565608891 3913 4817 A p53 inhibitor. SGTC_352 k048-0007 5.11 µM -0.83028366620978 0.203531106532478 no 2713 0.203189210396341 3894 6811911 SGTC_1016 4226-1401 38 µM -0.830441039459568 0.203483622087006 no 2714 0.203144735227983 3854 2901613 SGTC_2396 5342950 42.78 µM -0.83109143902478 0.203287446241919 no 2715 0.202960987811334 3892 1886677 SGTC_89 0302-0250 142.109 µM -0.833809947493863 0.202468702612884 no 2716 0.202194044456437 3957 4203518 YLR208W SEC13 SGTC_883 0850-0245 24.6 µM -0.835198042661171 0.202051406126548 no 2717 0.201803105789128 3973 6823229 YPR165W RHO1 SGTC_369 0957-0393 4.5 µM -0.835721287500612 0.201894239180308 no 2718 0.201655858334529 3909 6997992 SGTC_2988 9073640 71.4286 µM -0.835974585060915 0.201818182541792 no 2719 0.201584600447725 3925 9102229 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.835992620961663 0.201812767628857 no 2720 0.201579527148036 3891 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2398 5228213 48.84 µM -0.836784983553276 0.20157496272483 no 2721 0.201356719808582 3878 80771 YMR134W ERG29 SGTC_2808 7946468 45.46 µM -0.837158023197678 0.201463063723295 no 2722 0.201251874552074 3910 2970879 SGTC_2324 6149169 200 µM -0.837315570653365 0.201415816113826 no 2723 0.20120760463125 3810 2888231 SGTC_3145 9085516 49.47 µM -0.837505092420876 0.201358988385455 no 2724 0.201154357851919 3951 25236195 SGTC_2196 6573537 42.6665 µM -0.837740567013033 0.201288395183059 no 2725 0.201088212244674 3905 2903087 SGTC_2292 7671323 168.05 µM -0.838970371900254 0.200919951696842 no 2726 0.200742967935485 3938 937504 SGTC_158 k038-0087 26.446 µM -0.839058707902748 0.200893502251216 no 2727 0.200718182987783 3817 X158 SGTC_1591 genipin 88.4 µM -0.839956118924154 0.200624919105585 no 2728 0.200466495275198 3932 442424 A DNA cross-linking agent. SGTC_1411 3909-8223 150 µM -0.841723764946687 0.200096517186394 no 2729 0.19997129635822 3886 X1411 SGTC_3149 9097855 49.47 µM -0.84276882974565 0.199784510144477 no 2730 0.199678871946465 3911 25236625 YMR079W SEC14 SGTC_1227 3909-8010 46.6 µM -0.843837451543492 0.19946577290182 no 2731 0.199380122151372 3885 15982272 SGTC_1199 1638-0010 4.46 µM -0.845154546254005 0.199073345203203 no 2732 0.199012278380273 3872 3111136 SGTC_1770 st043884 66.3 µM -0.846312345158745 0.198728764076547 no 2733 0.198689261395603 3888 670149 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.84722579426194 0.198457159666933 no 2734 0.198434639371718 3872 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1433 4060-0023 7.6 µM -0.848532129237397 0.198069124198623 no 2735 0.198070843526139 3904 3840627 SGTC_218 alverine citrate 93.75 µM -0.849301628595955 0.197840765664778 no 2736 0.197856737434833 3926 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1309 pyrazolanthrone 13.4 µM -0.849565615801934 0.197762460827302 no 2737 0.197783317655942 3899 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1758 st042942 75.2445 µM -0.84957311885541 0.19776023551825 no 2738 0.197781231157072 3831 669317 SGTC_2518 prenyletin 46.28 µM -0.851210812334728 0.197274878872573 no 2739 0.197326128822812 3855 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1427 4048-4900 550 nM -0.851589722141271 0.197162685624153 no 2740 0.197220923020176 3910 24132586 SGTC_2970 9090938 41.86 µM -0.852338400873365 0.19694111922978 no 2741 0.197013149209 3961 17217104 SGTC_1670 st016595 4.04 µM -0.852614922302235 0.196859322719794 no 2742 0.196936442317451 3903 597879 SGTC_2214 7179297 48.276 µM -0.85295157981158 0.196759765408411 no 2743 0.196843078119731 3916 769744 SGTC_221 trifluoperazine 10.304 µM -0.853227736323433 0.19667812239236 no 2744 0.196766512491341 3875 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2482 5981709 142.65 µM -0.854947881206777 0.196170040239984 no 2745 0.1962900008081 3899 877755 SGTC_823 0417-1665 178 µM -0.855071902251108 0.196133438718438 no 2746 0.196255671763654 3926 3429856 SGTC_1624 st003710 6.25 µM -0.855492015855495 0.196009484111357 no 2747 0.196139411304526 3931 24207033 SGTC_1305 1181-0477 144 µM -0.855851705140615 0.195903395482291 no 2748 0.196039905611307 3957 6252086 SGTC_2595 hexamethylquercetagetin 100 µM -0.856124952428699 0.195822825797231 no 2749 0.195964334003178 3891 386331 SGTC_3118 9124250 49.47 µM -0.856887396923361 0.195598117805258 no 2750 0.195753559309887 3863 1504786 SGTC_2365 9042475 200 µM -0.857015336876987 0.195560426629166 no 2751 0.195718204314819 3997 6464479 SGTC_817 1391-0715 46 µM -0.857455458905885 0.195430800138493 no 2752 0.195596610363261 3926 1353946 SGTC_3062 9077494 49.47 µM -0.859281603663383 0.194893514458789 no 2753 0.195092585551661 3910 16459633 SGTC_1706 st031321 9.9705 µM -0.859821465193257 0.194734849369905 no 2754 0.194943732479885 3935 6103185 SGTC_3251 9135047 49.47 µM -0.860545077670443 0.194522303242221 no 2755 0.194744323113857 3922 17682963 SGTC_1976 st070609 63.5 µM -0.861591544821978 0.194215175117252 no 2756 0.194456162708195 3821 682556 SGTC_259 usnic acid 108.925 µM -0.86286597489899 0.193841541146921 no 2757 0.19410558002074 3992 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2841 9004761 38.96 µM -0.864243177557778 0.193438269521327 no 2758 0.193727158822747 3943 2991039 SGTC_1665 st014639 11.4 µM -0.865582735745097 0.193046512365356 no 2759 0.19335951324715 3969 981133 YIL048W NEO1 SGTC_2314 7727897 200 µM -0.866674465372929 0.192727591867248 no 2760 0.193060200019215 3940 900724 SGTC_2932 9016711 44.54 µM -0.867924605391526 0.192362791530801 no 2761 0.192717803989917 3939 7117328 SGTC_869 0564-0080 44.1 µM -0.869125973142868 0.192012621467294 no 2762 0.192389115868331 3949 6843321 SGTC_1357 1503-1303 39.5 µM -0.869232060997046 0.191981718142818 no 2763 0.192360107250609 3898 292895 SGTC_2976 9009005 19.48 µM -0.870034479928164 0.19174807261773 no 2764 0.192140780796659 3943 2993148 SGTC_423 5-fluorouracil 457 µM -0.870254747828526 0.191683966255435 no 2765 0.192080601392137 3891 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3279 9140807 49.47 µM -0.871345802726559 0.191366621226613 no 2766 0.191782684310375 3964 45595718 SGTC_2634 4'-methoxyflavone 100 µM -0.872128261074775 0.191139233193126 no 2767 0.191569205105652 3951 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1636 st007707 68.9 µM -0.872783601860727 0.19094891397819 no 2768 0.191390519624721 3956 403051 SGTC_2282 7944268 200 µM -0.873110159782531 0.190854120855224 no 2769 0.191301518351765 3945 2970414 SGTC_774 k060-0086 136 µM -0.874003499419924 0.190594950088001 no 2770 0.191058173998158 3902 5911235 SGTC_3113 9123498 49.47 µM -0.874304959195767 0.190507541018089 no 2771 0.190976099672154 3983 8897275 SGTC_2468 5987765 72.9 µM -0.874594333875733 0.190423659210965 no 2772 0.190897335935775 3976 26772094 SGTC_379 3970-0972 5.9 µM -0.875585364408446 0.190136558448716 no 2773 0.190627742325221 3929 2898042 YBL034C STU1 SGTC_188 3229-0966 278.469 µM -0.877035175503797 0.189717028810084 no 2774 0.19023376626377 3969 5722370 SGTC_316 k060-0003 58.6 µM -0.877284133620578 0.189645045496152 no 2775 0.190166163990346 3948 6152314 SGTC_8 0354-0001 70 µM -0.878693233037598 0.189237937697778 no 2776 0.189783814360347 3931 4993152 SGTC_3300 9124615 50.48 µM -0.879859126801904 0.188901502394019 no 2777 0.189467814615801 4002 24824903 SGTC_2201 6605497 169.863 µM -0.879998847428676 0.188861208753992 no 2778 0.189429966966917 3878 670741 SGTC_2581 avocatin a 64 µM -0.880652228029536 0.188672852452606 no 2779 0.189253040404338 3936 6710728 A skin care supplement. SGTC_1625 st003711 30.1 µM -0.881449700679069 0.188443114336664 no 2780 0.189037233596612 4009 24207034 YER133W GLC7 SGTC_131 0141-0277 33.849 µM -0.882431436389222 0.188160530256548 no 2781 0.188771770983854 3925 1547771 SGTC_2294 7971431 200 µM -0.882888936088676 0.188028932325147 no 2782 0.188648140989238 3947 5741572 SGTC_1722 st034304 3.6505 µM -0.891076133011709 0.1856835331262 no 2783 0.186444164010293 3959 4036148 YLR033W RSC58 SGTC_2041 5107442 45.335 µM -0.893128491554962 0.185098448159578 no 2784 0.185894183367392 3993 793005 SGTC_871 0574-0004 149 µM -0.893201631114112 0.185077618739249 no 2785 0.185874602382464 3935 9551173 SGTC_1114 scopoletin 1.73284 µM -0.894458622710668 0.18471986759641 no 2786 0.1855382794426 3968 5280460 A coumarin with genotoxic properties. SGTC_1160 4092-0570 10.5 µM -0.894484166575462 0.184712602041982 no 2787 0.185531448797697 3947 4994975 SGTC_897 1000-0139 31.4 µM -0.895193003378119 0.184511055330943 no 2788 0.185341962116815 3920 6151020 SGTC_1184 1269-1718 139 µM -0.897147836269147 0.183955938127684 no 2789 0.184820017901064 4034 5403821 SGTC_564 3555-0129 330 µM -0.89764630638422 0.183814553301552 no 2790 0.184687071725558 3815 563260 SGTC_347 4534-1311 26.2 µM -0.898957104921048 0.183443084792167 no 2791 0.18433775456593 3975 2862016 SGTC_3207 9114163 49.47 µM -0.899680874988425 0.183238175545324 no 2792 0.184145051999187 4002 849233 SGTC_659 k018-0002 107 µM -0.9001740515031 0.183098632305184 no 2793 0.184013816436451 3980 6797879 YHR007C ERG11 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.900517706490574 0.183001435063986 no 2794 0.183922403379286 3959 442882 SGTC_2662 daunorubicin 22.37 µM -0.903417739851856 0.182182490310737 no 2795 0.183152114174906 3856 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.90350451224176 0.182158021873605 no 2796 0.183129097269905 4012 521171 SGTC_678 1218-2179 85.9 µM -0.903552883335055 0.182144382884557 no 2797 0.183116267326054 3945 6820081 YOR116C RPO31 SGTC_1282 0886-0010 32.4 µM -0.904033730454479 0.182008835206884 no 2798 0.182988757978663 4033 2836211 YNL267W PIK1 SGTC_1086 cerivastatin 2.18 µM -0.906360350695234 0.181353867351624 no 2799 0.18237257587789 3943 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2763 lisinopril 49.32 µM -0.908205761936911 0.18083541570922 no 2800 0.18188476021407 3865 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1148 3909-7663 27.7 µM -0.908874807742403 0.180647683016715 no 2801 0.181708106523543 4019 4084526 SGTC_2879 9041815 71.43 µM -0.909740031523619 0.180405084530681 no 2802 0.181479813578763 3990 4942971 SGTC_1567 st069303 68.4 µM -0.909818053214454 0.180383218225364 no 2803 0.181459236055231 4063 5581319 SGTC_2239 6685329 187.64 µM -0.910160136369531 0.180287365865623 no 2804 0.181369031922752 4042 805680 SGTC_463 ikarugamyin 104 µM -0.911993028891595 0.17977433044402 no 2805 0.180886193637508 4050 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_965 1291-5240 308 µM -0.914278999789213 0.179135762839247 no 2806 0.18028513117876 4004 2834598 SGTC_3073 9114972 49.47 µM -0.917044964322558 0.178365023131018 no 2807 0.179559539324604 3982 41905075 SGTC_1012 4112-3522 18 µM -0.917999995780814 0.178099388323435 no 2808 0.179309434034252 4022 3112398 SGTC_75 0159-0059 199.013 µM -0.918039146154522 0.178088504265871 no 2809 0.179299185943006 4059 5377270 SGTC_2383 9036125 200 µM -0.918237302810034 0.178033421864316 no 2810 0.179247321654311 3901 79580 SGTC_627 1391-0720 175 µM -0.918916454526018 0.177844716843529 no 2811 0.179069636308528 3966 997839 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.918939811514018 0.177838229255814 no 2812 0.179063527429927 3988 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2968 9090663 33.37 µM -0.926265627327312 0.175810794975858 no 2813 0.17715397713313 3973 25236811 SGTC_1671 st016596 74.5 µM -0.927814021260925 0.17538415541802 no 2814 0.176752024788583 4055 2829167 SGTC_1615 st002656 86.5 µM -0.929412065398803 0.174944524293842 no 2815 0.176337788686287 3994 1584458 SGTC_2473 5854593 8.94 µM -0.933138955885813 0.173921955182307 no 2816 0.175374113911646 3914 2872951 SGTC_119 0121-0043 24.815 µM -0.936220255030576 0.173079397027241 no 2817 0.174579898263403 4029 1092378 SGTC_988 1497-1057 103 µM -0.937845382947289 0.172636067031779 no 2818 0.17416193731174 3934 3533044 SGTC_589 1227-0070 34.1 µM -0.938228134063301 0.172531759111818 no 2819 0.174063591502209 4069 2841384 SGTC_1030 k029-0042 36.7 µM -0.940465920612337 0.171922718726386 no 2820 0.173489311243975 4005 6080581 SGTC_2138 5575593 77.673 µM -0.941218796036786 0.171718123655147 no 2821 0.173296373210435 3990 762213 SGTC_63 0099-0242 26.702 µM -0.941363820100886 0.171678731011194 no 2822 0.173259223852375 4061 3898502 YLR359W ADE13 SGTC_1122 capsaicin 818.572 nM -0.9416213716169 0.171608786954513 no 2823 0.173193261967406 4095 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3026 9090633 49.47 µM -0.94324256530077 0.171168932478847 no 2824 0.17277842298707 4024 25236842 SGTC_1797 st048695 56.8 µM -0.943453176670397 0.171111843374485 no 2825 0.172724577238617 4007 592262 YIL048W NEO1 SGTC_655 k060-0012 42 µM -0.944841085752789 0.170735936145976 no 2826 0.172370006386222 4014 5994525 SGTC_2435 5706476 10.6 µM -0.945848414193819 0.170463438286789 no 2827 0.172112953946006 4019 5725375 SGTC_1913 st060213 96.1 µM -0.946253630417395 0.170353899654429 no 2828 0.172009618959442 4074 688959 SGTC_526 4469-0568 170 µM -0.946308277545802 0.170339130815034 no 2829 0.171995686319107 3964 2901964 SGTC_1813 st051246 8.6015 µM -0.946765416672811 0.170215617305684 no 2830 0.171879163952286 3938 5291959 SGTC_694 1315-0438 43.2 µM -0.947860085331643 0.169920084255659 no 2831 0.171600343582284 4006 6793154 SGTC_237 nikkomycin 200 µM -0.949035529575438 0.169603110322062 no 2832 0.171301271005926 4058 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_634 1611-4317 11.2 µM -0.950035101813038 0.169333861214645 no 2833 0.171047208523673 4013 2843522 SGTC_2506 ethyl hematommate 54.16 µM -0.950296521878029 0.169263489258329 no 2834 0.170980802850679 4103 3940691 An allergen. SGTC_1081 sertraline 6 µM -0.956522017005666 0.167593190289538 no 2835 0.169404283175748 4033 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2769 toremifene 3.73 µM -0.956624290776094 0.167565839199212 no 2836 0.169378461904766 4062 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3106 9121286 49.47 µM -0.956650340801828 0.167558873096266 no 2837 0.169371885404392 4062 15943471 SGTC_2499 avocadenofuran 51.48 µM -0.962372400117846 0.166033244470995 no 2838 0.167931286281794 4012 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.963712138830124 0.165677341106082 no 2839 0.167595133374369 4039 3256 An antibiotic and ribosome inhibitor. SGTC_516 3992-2719 87.3 µM -0.966337633598255 0.164981306682472 no 2840 0.166937630213194 3987 5350887 YDR037W KRS1 SGTC_2430 5571206 200 µM -0.966429408044885 0.16495701102419 no 2841 0.166914677255314 4073 1731771 SGTC_3050 9093513 49.47 µM -0.966598253240672 0.164912318303515 no 2842 0.166872454079163 4027 25236664 SGTC_2907 7721985 69.9 µM -0.970244297280292 0.163949136736112 no 2843 0.165962367639875 4095 3267881 SGTC_502 l-744,832 89.3 µM -0.970347464190482 0.163921936169213 no 2844 0.16593666297257 4066 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1371 2421-0008 32.7 µM -0.975035489720122 0.162689000714341 no 2845 0.164771328017477 4029 2827552 SGTC_859 0439-0102 54.6 µM -0.977247969839287 0.162109226322667 no 2846 0.164223202388833 4071 610143 SGTC_196 k015-0023 18.111 µM -0.978393346085989 0.16180961283271 no 2847 0.16393990893306 3992 5211998 SGTC_1961 st076550 68.7 µM -0.97888755359062 0.161680446963528 no 2848 0.163817771320582 4095 1579337 SGTC_1555 citronellol 128 µM -0.979345605069898 0.161560790843527 no 2849 0.163704621995592 4027 8842 A terpine precursor. SGTC_2545 solidagenone 89.61 µM -0.979823758827062 0.161435945038842 no 2850 0.163586561078201 3868 6708572 An anti ulcer agent SGTC_1329 1447-1697 50.6 µM -0.980227399571005 0.161330603542044 no 2851 0.163486941209139 4069 2840515 SGTC_281 1672-3440 14.9 µM -0.981471179836519 0.161006285804391 no 2852 0.163180219938471 4112 6833000 SGTC_844 0330-0132 15.3 µM -0.981705731236595 0.160945173863176 no 2853 0.163122420545542 4120 2828079 SGTC_278 4092-0821 23.9 µM -0.98201442121852 0.160864768327747 no 2854 0.163046371813907 4073 877900 SGTC_1118 chelidonine 707.474 nM -0.982563049659739 0.160721929932973 no 2855 0.162911268833307 4053 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_419 nsc-638432 893 µM -0.982685785955027 0.160689986212286 no 2856 0.162881054264871 4023 368090 SGTC_735 3076-0345 636 µM -0.983091489227851 0.160584426153044 no 2857 0.162781206321057 4132 2888990 SGTC_1336 1486-0901 104 µM -0.985775978234802 0.15988708984772 no 2858 0.162121528052482 4095 5006114 SGTC_3124 9127567 49.47 µM -0.987567998379512 0.159422689806237 no 2859 0.161682132739982 4080 17592030 SGTC_2652 actinonin 100 µM -0.988090594805181 0.159287426003617 no 2860 0.161554140758093 4076 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2985 9022375 71.43 µM -0.990969930949391 0.158543514678021 no 2861 0.160850131553977 4148 4939335 SGTC_2198 6589944 200 µM -0.995640548329573 0.157341657614106 no 2862 0.159712412908262 4084 5290268 SGTC_1622 st003707 19.4 µM -0.99793200955426 0.156754207746344 no 2863 0.159156164481666 4107 10140899 SGTC_2680 butyl paraben 22.24 µM -0.999829382759942 0.156268881988534 no 2864 0.158696541830562 4157 7184 An antifungal and steroid mimetic. SGTC_992 3909-8734 162 µM -1.00000998313218 0.156222738184746 no 2865 0.158652838317788 4102 4288319 SGTC_2248 tofa 1.1 µM -1.00206014499564 0.155699546585134 no 2866 0.158157272639645 4045 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_787 4152-0075 138 µM -1.00216637986495 0.155672467475624 no 2867 0.158131621234219 4101 9566539 SGTC_482 fipronil 114 µM -1.004897756754 0.154977310158349 no 2868 0.157473042369019 4169 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2688 kanamycin b 96.69 µM -1.00683237844277 0.154486175581068 no 2869 0.157007666091099 4160 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_863 0466-0191 129 µM -1.01132023137719 0.153350828300974 no 2870 0.155931593001473 4136 765160 YPR165W RHO1 SGTC_130 0136-0219 337.655 µM -1.01189900295756 0.153204812778732 no 2871 0.155793173027837 3941 234244 SGTC_621 3584-0052 32.1 µM -1.01252101872388 0.153047990135667 no 2872 0.155644501055012 4117 2273927 SGTC_3342 9147791 14.508 µM -1.01562162296974 0.152267853367891 no 2873 0.15490480198173 4004 1838168 SGTC_1381 2324-0066 62.1 µM -1.01685285163541 0.151958799995338 no 2874 0.15461171768418 4164 10885928 SGTC_2055 5235184 200 µM -1.01763758918018 0.151762038898595 no 2875 0.154425108431565 4170 2836034 SGTC_1819 st053448 58.6 µM -1.01815853627085 0.151631512819489 no 2876 0.154301310368143 4009 2857616 SGTC_1007 4101-0031 70 µM -1.01931905021712 0.151341008188202 no 2877 0.154025761402207 4082 1146276 SGTC_945 3381-0768 11.3 µM -1.02152743256142 0.150789219832032 no 2878 0.153502309454854 4153 1126236 YIL048W NEO1 SGTC_1480 1070-0044 41.2 µM -1.02170610526644 0.150744635154059 no 2879 0.153460010316154 4125 3124987 SGTC_1891 st059073 26.2 µM -1.02304671289559 0.150410389764492 no 2880 0.153142879945249 4188 688754 SGTC_251 melphalan 456.522 µM -1.02424959607294 0.15011090296076 no 2881 0.15285869924639 4131 460612 A DNA alkylator. SGTC_358 0075-0058 9.45 µM -1.02469007287297 0.150001335132874 no 2882 0.152754724294496 3937 1069125 SGTC_3170 9103054 49.47 µM -1.02469892002677 0.149999134965382 no 2883 0.152752636396401 4097 16432970 SGTC_1964 st076914 61 µM -1.02765348662371 0.149265577628856 no 2884 0.152056427372229 4160 24208661 SGTC_1683 st010134 710 nM -1.02837548789257 0.149086684565215 no 2885 0.151886617150394 4104 3818134 SGTC_697 0508-1955 564 µM -1.02875342539147 0.148993098645718 no 2886 0.151797778848774 4117 6243113 SGTC_3155 9099265 49.47 µM -1.03022328228093 0.148629501848451 no 2887 0.151452601390098 4144 25236499 SGTC_2894 9048625 32.47 µM -1.03282197516234 0.147988118794899 no 2888 0.150843608935564 4118 4092861 SGTC_396 dithiazanine 1.25 µM -1.03310937852135 0.147917298754224 no 2889 0.15077635745168 4126 10578 An antihelmenthic. SGTC_747 3448-8087 38.7 µM -1.03323527344216 0.147886283704962 no 2890 0.150746904723707 4170 5168703 SGTC_2420 aureobasidin a 50 nM -1.03356505266254 0.147805061045887 no 2891 0.150669772054187 4254 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_81 0411-0046 9.971 µM -1.03424505817897 0.1476376740469 no 2892 0.150510807293485 4063 12925265 SGTC_2828 7998861 71.43 µM -1.03587190360592 0.147237732747057 no 2893 0.150130953455067 4101 2988188 SGTC_873 0591-4978 488 µM -1.03599435148202 0.147207659755317 no 2894 0.150102388855245 4218 3305145 SGTC_1928 4'-methoxychalcone 40.3 µM -1.03612969486181 0.147174424440705 no 2895 0.150070820212428 4171 641818 SGTC_2791 5663188 71.43 µM -1.03633492347884 0.147124037501362 no 2896 0.150022959386935 4173 54690634 SGTC_3345 9148410 3.559 µM -1.03644349303201 0.1470973866011 no 2897 0.149997644283736 4092 4903596 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.03803183222392 0.146707862195135 no 2898 0.149627617753541 4138 77254 SGTC_2067 5224629 34.075 µM -1.03822134477584 0.146661432383114 no 2899 0.149583508776647 4146 2835000 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.03841269473363 0.146614562419219 no 2900 0.149538980948673 4190 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2322 7413319 38.22 µM -1.03913851260728 0.146436869301754 no 2901 0.14937016092281 4170 1840400 SGTC_2716 st080858 38.6235 µM -1.03979609113993 0.146276007264384 no 2902 0.149217322770935 4099 5296050 SGTC_260 nsc-65238 3.989 µM -1.04533278270259 0.144926284873378 no 2903 0.147934595608875 4122 3246252 SGTC_2369 9071472 200 µM -1.04649295259203 0.144644527199734 no 2904 0.147666748497309 4203 17296037 SGTC_34 0469-0683 81.75 µM -1.04880166893195 0.144084933094922 no 2905 0.147134704601612 4104 3690923 SGTC_1873 rapamycin 2 nM -1.05060446645722 0.143648981579856 no 2906 0.146720144428859 4102 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2820 7989630 71.43 µM -1.05102483290139 0.143547456914044 no 2907 0.146623592347055 4154 2984098 SGTC_2778 tioconazole 65.09 nM -1.05162302509286 0.143403068239414 no 2908 0.146486269794159 4036 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_967 1306-0166 352 µM -1.05346471534704 0.142959146017336 no 2909 0.146064028799679 4154 4437607 SGTC_1688 st021091 57.6 µM -1.05389148021894 0.142856411001436 no 2910 0.145966301991812 4170 3656366 SGTC_727 3032-0951 202 µM -1.05413626471283 0.142797506607459 no 2911 0.145910267520972 4176 3652836 SGTC_708 3448-5400 146 µM -1.05486618273855 0.142621958243308 no 2912 0.145743265270507 4090 3462195 SGTC_1896 st058441 89 µM -1.0554787349301 0.142474749520729 no 2913 0.145603215038387 4153 688759 SGTC_375 3970-0961 9.27 µM -1.05553476277632 0.142461290023999 no 2914 0.145590409688554 4095 2898222 SGTC_601 0986-0029 62.9 µM -1.0569082263578 0.142131613596044 no 2915 0.145276736845029 4098 24747981 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.0577070687623 0.141940102831437 no 2916 0.145094505788269 4077 1241132 A phosphatase inhibitor. SGTC_1028 k015-0029 4.8 µM -1.06297584725631 0.140681367453107 no 2917 0.143896452286807 4102 4588309 SGTC_2106 5357045 167.29 µM -1.06319781013443 0.140628506314729 no 2918 0.143846127646878 4170 668842 SGTC_1849 st056239 19.2 µM -1.06339162308515 0.140582360193989 no 2919 0.143802195023993 4165 5393181 SGTC_3292 9120825 59.784 µM -1.06626155923754 0.139900242317664 no 2920 0.143152710674187 4172 24824900 SGTC_1094 duloxetine 25.4 µM -1.06659497500337 0.139821143142297 no 2921 0.143077385296418 4169 60834 A selective serotonin reuptake inhibitor. SGTC_292 k038-0015 474 µM -1.06682973091007 0.139765468160081 no 2922 0.143024365247443 4162 46368540 SGTC_940 3232-1287 54.8 µM -1.06711635213857 0.139697513173892 no 2923 0.14295964932198 4119 1585493 YIL048W NEO1 SGTC_1844 rapamycin 4 nM -1.06729321454978 0.13965559209944 no 2924 0.142919725605925 4055 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_840 0245-0196 390 µM -1.06876330982598 0.139307471643143 no 2925 0.142588167927585 4248 3827528 SGTC_2113 5491891 107.031 µM -1.06898701943122 0.139254548724743 no 2926 0.142537759256082 4164 789979 SGTC_176 1486-1328 72.834 µM -1.07073200015216 0.138842208697992 no 2927 0.14214497496395 4238 22310231 SGTC_2859 9028643 45.46 µM -1.07124450943557 0.138721260560888 no 2928 0.142029751619299 4025 17151580 SGTC_1737 st035557 69.7 µM -1.07165616076983 0.138624166087364 no 2929 0.141937249156175 4028 5716916 SGTC_901 1112-0062 60.1 µM -1.07241175046408 0.138446068821177 no 2930 0.141767566228244 4190 1908457 SGTC_41 0478-0632 82.643 µM -1.07310680077796 0.13828237881862 no 2931 0.141611600003597 4121 3750424 SGTC_2553 4-methylesculetin 85.09 µM -1.07837950016172 0.137044912363537 no 2932 0.140432215807579 4199 5319502 SGTC_2488 5268135 45.7 µM -1.08069859369202 0.136503040100192 no 2933 0.139915604434561 4229 1270356 YLR208W SEC13 SGTC_1188 1403-0014 4.57 µM -1.08078007397194 0.136484028353531 no 2934 0.139897477050258 4162 9614867 SGTC_546 peri-Naphthalide 147 µM -1.08124602138793 0.136375343904262 no 2935 0.139793845725129 4101 223824 A penicillin ester. SGTC_454 lyso-paf C-16 6.67 µM -1.0837957882941 0.135781647280952 no 2936 0.139227676519576 4199 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1120 ficusin 1.78878 µM -1.08381495312246 0.135777191588181 no 2937 0.139223426935265 4229 6199 A DNA cross-linker. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.08555191323919 0.135373775905066 no 2938 0.138838642134542 4200 2374 Ca(2+)-ATPase inhibitor. SGTC_1130 3454-2858 15.9 µM -1.08951530474262 0.134456341269197 no 2939 0.13796335473502 4212 715628 YIL048W NEO1 SGTC_2923 7992654 58.14 µM -1.09057719196756 0.134211265361334 no 2940 0.137729485047611 4183 2985126 SGTC_1717 st033143 58.0435 µM -1.09135323397922 0.13403235463207 no 2941 0.137558741009651 4255 674616 SGTC_1136 pergolide 1.05886 µM -1.09202301688834 0.133878072955355 no 2942 0.137411492215641 4151 47811 A dopamine receptor agonist. SGTC_2431 5490079 200 µM -1.09224932286964 0.133825971922013 no 2943 0.137361764186359 4244 5722345 SGTC_212 3807-4682 38.772 µM -1.09260505899386 0.133744101158845 no 2944 0.137283620277203 4266 3125501 YBL034C STU1 SGTC_3035 9091303 49.47 µM -1.09422743737077 0.133371156104865 no 2945 0.136927620385085 4251 25237002 SGTC_2049 5262831 67.185 µM -1.09638889468255 0.132875402411227 no 2946 0.13645431090288 4183 763417 SGTC_1908 st060353 56.5 µM -1.09683369552485 0.132773540136713 no 2947 0.136357048750122 4255 4227716 SGTC_2263 7948595 193.29 µM -1.09710964187808 0.132710373671084 no 2948 0.136296732924288 4180 2971371 SGTC_137 0438-0332 85.389 µM -1.09717805468048 0.13269471660153 no 2949 0.136281782209185 4138 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1234 0326-0494 15.5 µM -1.09782709655363 0.132546239075129 no 2950 0.136139998495588 4271 1547813 SGTC_178 4092-0806 87.505 µM -1.09833264323659 0.132430667437245 no 2951 0.136029631387782 4073 2169044 SGTC_2426 5582046 32.21 µM -1.09998438626944 0.132053551181396 no 2952 0.135669462460787 4209 2251934 SGTC_499 genistein 192 µM -1.10196538387099 0.13160223899551 no 2953 0.135238360560959 4281 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1828 st055811 49 µM -1.10362464186628 0.131225045861414 no 2954 0.134877998640148 4201 5877589 SGTC_1600 coumarin 106 71.1 µM -1.1049365852806 0.130927335560012 no 2955 0.134593534134585 4271 100336 A hepatotoxic, DNA x-linker. SGTC_3177 9107506 49.47 µM -1.10550252885888 0.13079905407765 no 2956 0.134470949618012 4152 8897194 SGTC_2218 6965428 192.983 µM -1.10583811443964 0.130723028499446 no 2957 0.13439829731818 4098 675684 SGTC_2311 7694451 200 µM -1.10623871108551 0.130632314926894 no 2958 0.134311605801387 4174 2163142 SGTC_1652 st011932 78 µM -1.10631175621882 0.130615778829559 no 2959 0.134295802536847 4146 1551076 SGTC_3263 9137018 49.47 µM -1.10868862928028 0.130078487397548 no 2960 0.133782264425832 4168 43844957 SGTC_3081 9117243 49.47 µM -1.11251242500502 0.129217333048675 no 2961 0.132958945454524 4188 45595589 SGTC_2996 9066192 71.4286 µM -1.11299315902509 0.129109347581423 no 2962 0.132855683787285 4241 6472854 SGTC_2448 5185112 27.17 µM -1.11470295975167 0.128725788570455 no 2963 0.132488866138436 4239 5718189 SGTC_1998 st075797 76.8 µM -1.11975775892828 0.127596473542752 no 2964 0.131408502143036 4201 24208315 SGTC_1617 st002906 78 µM -1.12037499591899 0.127459047260142 no 2965 0.13127699776058 4201 5150859 SGTC_2270 7924575 90.91 µM -1.12066910235854 0.127393601412298 no 2966 0.131214369390131 4207 1262135 SGTC_2210 7115885 190.385 µM -1.12157958211598 0.12719114566869 no 2967 0.13102061850302 4290 2927039 SGTC_2512 diallyl trisulfide 49.23 µM -1.12422217245968 0.126604803175561 no 2968 0.130459392737592 4241 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1087 pterostilbene 9.05 µM -1.12560840539261 0.126297977386657 no 2969 0.130165654356389 4237 5281727 Similar to reservatol, lowers cholesterol. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.12585710727468 0.126242985122027 no 2970 0.130113003670461 4211 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1512 0259-0544 12.2 µM -1.12601710624331 0.126207615420319 no 2971 0.130079139360644 4193 18476 SGTC_2737 bleomycin 30.5 nM -1.12729451835238 0.125925475765894 no 2972 0.129808989634664 4290 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2355 9061122 103.12 µM -1.12783327389334 0.125806613794463 no 2973 0.129695169068613 4234 5302957 SGTC_714 4296-0578 26.1 µM -1.12943548304565 0.12545359178555 no 2974 0.129357085742503 4257 1589775 SGTC_64 000l-0018 272.079 µM -1.1316538330047 0.124965954912349 no 2975 0.128889999063424 4145 6811119 SGTC_2153 5569715 200 µM -1.13195479956984 0.124899898698637 no 2976 0.128826719011628 4263 2054701 SGTC_382 3229-0966 23.2 µM -1.13608348500599 0.123996195968314 no 2977 0.12796081306037 4258 5722370 SGTC_448 monastrol 171 µM -1.13645562506202 0.123914965886187 no 2978 0.127882963558807 4149 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1106 tegaserod maleate 11.7 µM -1.13749315838383 0.123688691617684 no 2979 0.127666091526828 4244 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1749 st037932 54.2 µM -1.13821435925407 0.123531576417262 no 2980 0.12751549208893 4262 594497 SGTC_2978 9011784 42.97 µM -1.13895395545351 0.123370598980965 no 2981 0.127361179723864 4210 2994934 SGTC_1487 3970-0795 2.82 µM -1.13971788500934 0.123204479604427 no 2982 0.127201926763295 4271 3765103 SGTC_959 1222-0044 107 µM -1.14090618632291 0.122946390652596 no 2983 0.126954482387166 4227 6083612 SGTC_1692 fluoroquinolonic acid 71 µM -1.14159253016737 0.122797495413387 no 2984 0.126811715212096 4256 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_50 0929-0078 56.389 µM -1.14299632379679 0.12249335077425 no 2985 0.126520058694852 4084 1377751 SGTC_3189 9110682 49.47 µM -1.14488993344732 0.122083921044505 no 2986 0.126127377243545 4296 17122418 SGTC_2849 9019321 12.99 µM -1.14528106769513 0.121999471236925 no 2987 0.126046372970023 4270 16489627 SGTC_688 0527-0193 473 µM -1.14841858623411 0.121323533895541 no 2988 0.125397902267421 4291 4007154 SGTC_2975 9084847 53.72 µM -1.15264389752511 0.120417413388247 no 2989 0.124528288772907 4299 27211724 SGTC_1868 st057644 42.7 µM -1.15690985921979 0.119507421550325 no 2990 0.123654595104807 4266 688665 SGTC_195 4234-0266 16.654 µM -1.15717888068265 0.119450198404828 no 2991 0.123599642186119 4248 2303354 SGTC_2460 5552655 174.22 µM -1.15797870921304 0.119280182283887 no 2992 0.12343636251402 4277 5401989 SGTC_970 1315-0089 19.5 µM -1.159423621211 0.118973476631478 no 2993 0.123141776508643 4204 6811083 YLR033W RSC58 SGTC_2043 5101342 149 µM -1.16062443518616 0.118719008736291 no 2994 0.122897331949062 4259 678451 SGTC_168 3970-0862 530.542 µM -1.16071820903377 0.118699153052662 no 2995 0.122878257140997 4211 3135186 SGTC_1521 st012942 49.4 µM -1.16175854989296 0.118479028565251 no 2996 0.122666777679883 4214 24207259 SGTC_1936 st074407 74.3 µM -1.16186927548645 0.118455617267284 no 2997 0.122644284532705 4281 809813 SGTC_2251 lansoprazole 556 µM -1.16259116284616 0.118303064951203 no 2998 0.122497708974894 4178 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2052 5265182 7.135 µM -1.1646962040582 0.117859011889619 no 2999 0.122070993035198 4260 1239884 SGTC_2445 5742597 35.57 µM -1.16551582490809 0.117686434354991 no 3000 0.121905129177179 4247 1774255 SGTC_381 3461-2219 42.7 µM -1.17039821475708 0.116662115001909 no 3001 0.120920376884045 4259 2883159 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.17109825747286 0.116515766684583 no 3002 0.120779642105772 4248 688662 SGTC_86 0417-1630 471.922 µM -1.17550361907036 0.115597785935257 no 3003 0.119896645065721 4270 3634867 SGTC_2271 7849410 118.62 µM -1.17563286638228 0.115570931433081 no 3004 0.11987080803309 4205 972430 SGTC_2935 9038016 29.96 µM -1.17604356408276 0.115485627686682 no 3005 0.119788734044755 4245 6463195 SGTC_1400 3771-8998 51.5 µM -1.17613757211734 0.115466108092133 no 3006 0.119769953016826 4192 670767 SGTC_1020 4335-0961 93.3 µM -1.17786276198791 0.1151083101719 no 3007 0.119425661334695 4225 669075 SGTC_1948 st076329 66.6 µM -1.17921441928685 0.114828532816617 no 3008 0.119156402900869 4174 24208413 SGTC_1927 st060202 13.8 µM -1.18205898433145 0.114241322006093 no 3009 0.118591148701988 4190 688887 SGTC_181 1447-1644 8.07 µM -1.18357163605391 0.113929933837256 no 3010 0.118291336893411 4249 534600 SGTC_1402 3909-7673 35.9 µM -1.18484494107663 0.113668285760428 no 3011 0.118039379994242 4292 5328014 SGTC_3218 9131285 49.47 µM -1.18683453738026 0.113260306954868 no 3012 0.117646446400522 4269 17156417 SGTC_2819 7996655 46.38 µM -1.18741725101921 0.113141016002865 no 3013 0.117531539365698 4227 6456960 SGTC_2061 5245884 80.95 µM -1.18809480689486 0.11300242206087 no 3014 0.11739803004343 4260 573863 SGTC_399 oxolinic acid 75 µM -1.191591840634 0.112289030877381 no 3015 0.116710662947311 4250 4628 A DNA gyrase inhibitor. SGTC_1840 st055363 71 µM -1.19190821207323 0.112224650547184 no 3016 0.116648618912626 4315 676033 SGTC_953 1188-0045 9.7 µM -1.19416579941174 0.111766006207318 no 3017 0.116206559239137 4286 6144426 SGTC_1933 st074711 15.9 µM -1.19425080577727 0.11174876281195 no 3018 0.116189937342941 4257 17250958 SGTC_2833 9001315 45.46 µM -1.1953196035682 0.111532121372861 no 3019 0.115981091710061 4238 2989378 SGTC_2649 anisomycin 9.56 µM -1.19595222784814 0.111404032399808 no 3020 0.115857601047821 4320 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2628 lathosterol 100 µM -1.19980188961937 0.110626851476203 no 3021 0.115108145067902 4355 6710616 SGTC_2836 9010338 19.48 µM -1.20164501483518 0.110256134732639 no 3022 0.114750546506053 4261 2994051 SGTC_3331 9141060 1.957 µM -1.20200373036635 0.110184088227682 no 3023 0.11468104139849 4238 4906567 YPR165W RHO1 SGTC_976 1348-1067 47.6 µM -1.20583379904989 0.109416939486576 no 3024 0.113940790218859 4297 5310671 YGL099W LSG1 SGTC_160 3453-0671 289.699 µM -1.20719689064254 0.109144845006139 no 3025 0.113678163818282 4317 5322268 SGTC_893 0958-0369 48.9 µM -1.21002291730848 0.108582275496545 no 3026 0.113135049586589 4206 6819948 SGTC_1556 plumbagin 1.48 µM -1.21168989536596 0.108251414285341 no 3027 0.112815554267757 4224 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_762 1165-0429 115 µM -1.21543407771186 0.107510916949961 no 3028 0.11210028867276 4299 5967793 SGTC_500 h-89 112 µM -1.2165244225716 0.107295964335008 no 3029 0.111892606679258 4291 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.21767659415982 0.107069159958826 no 3030 0.111673447470142 4295 688751 SGTC_1675 st018485 24.5 µM -1.21846102130051 0.106914943857668 no 3031 0.111524414230887 4332 3323024 SGTC_2629 bisabolol 100 µM -1.21935003275303 0.106740360577203 no 3032 0.111355683141802 4335 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_469 w7 172 µM -1.22274363878175 0.106075818913725 no 3033 0.110713269514755 4387 45115570 A P450 inhibitor. SGTC_475 α-linolenic acid 10 µM -1.224170761101 0.105797252074123 no 3034 0.110443908354989 4314 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_479 n-linoleoylglycine 10 µM -1.22502368189731 0.105631019045219 no 3035 0.110283148929707 4351 6433346 An anti-infammatory. SGTC_2955 9076254 12.21 µM -1.22580202705766 0.105479485584209 no 3036 0.110136592106623 4211 16459619 SGTC_2382 9035899 200 µM -1.22877906378082 0.104901346862107 no 3037 0.109577326610431 4296 6462679 SGTC_3144 9087057 49.47 µM -1.23292665751818 0.104099716370319 no 3038 0.108801564374384 4222 17249618 SGTC_3293 9120939 62.045 µM -1.23897875500857 0.102937973803144 no 3039 0.107676682948949 4312 934087 SGTC_797 k781-0471 270 µM -1.24105601296363 0.102541408905824 no 3040 0.107292528754775 4288 23738129 SGTC_2948 9070189 9.45 µM -1.24143553916328 0.10246907452761 no 3041 0.107222448606426 4261 6473636 YDL196W YDL196W SGTC_3168 9103419 49.47 µM -1.25130898219867 0.100600300915813 no 3042 0.105410884825299 4343 16649256 SGTC_661 1304-0007 33.6 µM -1.25423149896064 0.10005194632679 no 3043 0.104878936974127 4334 3117130 SGTC_2793 7325131 81.82 µM -1.2548628633219 0.0999337700458036 no 3044 0.104764273641539 4272 4176441 SGTC_2900 5328528 85.29 µM -1.2594787560778 0.099072881332602 no 3045 0.103928729370144 4336 795359 SGTC_87 0100-0052 35.5 µM -1.26023428843191 0.0989324886593632 no 3046 0.103792428481561 4375 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1361 1608-0041 5.61 µM -1.26071002272919 0.0988441626412748 no 3047 0.103706670775876 4311 X1361 SGTC_1048 3161-0300 24.5 µM -1.26210012177795 0.0985864040304421 no 3048 0.103456380732739 4327 2165101 SGTC_778 3456-2434 196 µM -1.26636862100859 0.0977979948422756 no 3049 0.102690569869593 4291 5539063 SGTC_1063 disulfiram 1.84 µM -1.26880609850807 0.0973498611743002 no 3050 0.102255114751979 4369 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1441 4106-0040 13 µM -1.26884471610029 0.0973427734186109 no 3051 0.102248226547592 4343 2904180 SGTC_2938 9059746 27.26 µM -1.27146698281976 0.0968623757836925 no 3052 0.101781283132092 4342 6471769 SGTC_2638 epoxomicin 18 µM -1.27411439710249 0.0963791393311274 no 3053 0.101311438402339 4317 9915668 A protesome inhibitor. SGTC_1115 galangin 695.678 nM -1.27507272283292 0.0962046521582297 no 3054 0.10114175152338 4421 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1930 st074634 34.3 µM -1.27722604955533 0.0958134324635871 no 3055 0.100761226401558 4246 684253 YOR116C RPO31 SGTC_3211 9128781 49.47 µM -1.27987295451055 0.0953341436620773 no 3056 0.100294910393827 4309 17194361 SGTC_643 k048-0106 28.4 µM -1.27994530979407 0.0953210667455671 no 3057 0.100282185423237 4374 6763920 SGTC_1696 st025591 34.7925 µM -1.28028071997882 0.0952604646352319 no 3058 0.100223212935874 4352 2787147 SGTC_510 ag-490 170 µM -1.28205818770491 0.0949397841805915 no 3059 0.0999111175168994 4481 5328779 SGTC_2393 9031399 185.94 µM -1.28286551944464 0.0947943929858557 no 3060 0.0997695973905139 4361 1526623 YDL150W RPC53 SGTC_27 0485-0001 32.618 µM -1.28320221910862 0.0947338057410329 no 3061 0.0997106193698629 4343 2054479 SGTC_3159 9100096 49.47 µM -1.2859569736742 0.0942391744693968 no 3062 0.0992290390961056 4295 25236875 SGTC_2865 9030313 51.95 µM -1.28613511360861 0.0942072541682886 no 3063 0.0991979557045089 4332 42562754 SGTC_1938 st074717 56.4 µM -1.29063764756823 0.0934031063871452 no 3064 0.0984146775218954 4231 17250979 SGTC_113 0099-0221 2.5 µM -1.29432994212235 0.0927474594881832 no 3065 0.0977757391265179 4328 89219 SGTC_2804 7954240 19.48 µM -1.29787784705734 0.0921206645900135 no 3066 0.0971646567822878 4390 828705 SGTC_3194 9111903 49.47 µM -1.29858491720808 0.0919961248368411 no 3067 0.0970432084401979 4387 17087251 SGTC_3175 9106517 49.47 µM -1.3025415461767 0.0913015243579573 no 3068 0.0963656625878722 4375 41468073 SGTC_1382 3002-2117 298 µM -1.30583515678873 0.0907262908218145 no 3069 0.0958043107628688 4441 1497314 SGTC_1064 honokiol 6.76 µM -1.30903626327161 0.0901697948859461 no 3070 0.0952610336607928 4398 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.30952030464226 0.0900858679522826 no 3071 0.0951790822073329 4340 756377 SGTC_204 PMA1.184 62.41 µM -1.31084690884174 0.0898561483083757 no 3072 0.0949547453610563 4334 2252213 YGL008C PMA1 SGTC_114 0364-0001 490.298 µM -1.31283598957483 0.0895125280361867 no 3073 0.094619109958443 4405 4003655 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.31381254842773 0.0893441823710948 no 3074 0.0944546468639335 4374 140250 A respiratory chain inhibitor. SGTC_581 0958-0271 211 µM -1.31497395721672 0.0891442778122642 no 3075 0.094259327551955 4385 4591145 SGTC_2612 dictamnine 15.46 µM -1.31677194443335 0.0888354605995251 no 3076 0.0939575398310805 4298 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_608 k048-0125 159 µM -1.31881804754511 0.0884849975373821 no 3077 0.0936149745944241 4415 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_413 propylparaben 100 µM -1.32298322359077 0.0877747573947562 no 3078 0.0929204784697072 4364 7175 A pharmaceutical preservative. SGTC_3316 9136639 10.545 µM -1.32475630701379 0.0874737073978108 no 3079 0.0926259954496688 4368 4903665 SGTC_2910 7948405 25.97 µM -1.32566065160735 0.0873204567438793 no 3080 0.0924760632467981 4330 2971328 SGTC_149 3970-0822 46.1 µM -1.3266515575768 0.0871527675912235 no 3081 0.092311986196516 4370 3114250 YBL034C STU1 SGTC_534 k292-0788 63.4 µM -1.32755772774279 0.0869996287357214 no 3082 0.0921621286375353 4423 4146317 SGTC_719 2810-4230 27.3 µM -1.32796002503145 0.086931706685983 no 3083 0.092095656625038 4398 721079 SGTC_2443 5493264 126.67 µM -1.32906715223535 0.0867449888779465 no 3084 0.0919129080752603 4428 5340055 SGTC_1133 3473-0247 50 µM -1.33010609640622 0.0865700429188191 no 3085 0.0917416585916581 4350 711311 SGTC_2918 7977171 22.06 µM -1.330648833558 0.0864787573173627 no 3086 0.0916522931085522 4379 2236483 SGTC_254 nsc-64875 3.808 µM -1.33264607566258 0.0861434511094311 no 3087 0.0913239885585008 4378 56993 SGTC_2850 9015429 58.44 µM -1.33401173379995 0.0859147386152484 no 3088 0.0911000055293024 4381 6457570 SGTC_713 1488-1073 324 µM -1.33485091545818 0.0857744229406917 no 3089 0.0909625727100816 4421 3312542 SGTC_2843 9000894 45.46 µM -1.33752695754587 0.0853281200359245 no 3090 0.0905253444412206 4361 2242070 SGTC_3231 9132313 49.47 µM -1.33948440414401 0.0850027657624715 no 3091 0.0902065141332878 4337 4905967 SGTC_2661 dactinomycin 12.96 µM -1.34059428435531 0.0848187021302127 no 3092 0.0900261069985656 4358 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_296 1222-0039 74.9 µM -1.34119844819965 0.0847186326971241 no 3093 0.089928015041805 4409 5984176 SGTC_1459 k035-0031 35.7 µM -1.34234079588554 0.0845296643017934 no 3094 0.0897427607468843 4131 3877128 YMR208W ERG12 SGTC_525 k781-2675 26.7 µM -1.34332132148196 0.0843677170243263 no 3095 0.0895839755027132 4349 3651118 YDL195W SEC31 SGTC_3336 9143619 71.43 µM -1.34630978725788 0.0838755669990063 no 3096 0.089101315370331 4410 45595730 SGTC_1850 st056238 17 µM -1.3463795033197 0.0838641117276557 no 3097 0.089090078838416 4416 5393177 SGTC_1213 1315-0166 115 µM -1.34942744228862 0.0833644428845225 no 3098 0.0885998556420084 4407 768401 SGTC_1700 st030840 7.9285 µM -1.35480170026553 0.0824888618764689 no 3099 0.0877403723811171 4434 5499307 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.35516180384908 0.0824304417674279 no 3100 0.0876830055994481 4422 66535 A nucleotide analog. SGTC_3003 9075612 71.4286 µM -1.35741850411459 0.0820650432267977 no 3101 0.087324135989194 4420 6501993 SGTC_3329 9141233 27.5565 µM -1.36180822008927 0.081357770342146 no 3102 0.0866292083619959 4368 4909101 YNL103W MET4 SGTC_2496 diffractaic acid 79.83 µM -1.36248512409328 0.0812491176966992 no 3103 0.0865224178405906 4401 94870 An apoptosis inducer which activates caspases. SGTC_1637 st007924 17.4 µM -1.36279641985955 0.0811991870976237 no 3104 0.0864733398827242 4322 683336 SGTC_1982 st072467 71.9 µM -1.36418408457926 0.0809768928102213 no 3105 0.0862548179785912 4392 3163533 SGTC_1743 st037606 46.3785 µM -1.36542503192657 0.0807784909730593 no 3106 0.0860597503839443 4369 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_545 4218-0007 221 µM -1.36611280030174 0.0806686892242404 no 3107 0.0859517806188614 4402 2840508 SGTC_907 3448-6986 75.5 µM -1.36725469647946 0.0804866352691447 no 3108 0.0857727432133609 4431 590582 SGTC_3015 9080845 49.47 µM -1.36908869439762 0.0801948884914315 no 3109 0.0854857759304116 4466 5296973 SGTC_1428 4049-0204 61.7 µM -1.36945872265819 0.0801361225525298 no 3110 0.0854279645522684 4450 X1428 SGTC_317 4495-0002 170 µM -1.3703563160236 0.0799937067628986 no 3111 0.0852878506984431 4436 15991618 SGTC_2711 st079103 59.1 µM -1.37434679890191 0.079362876419634 no 3112 0.0846670220105597 4354 54693780 SGTC_397 arbidol 50 µM -1.37479273664156 0.0792926154950909 no 3113 0.0845978552923631 4447 131410 A RNA synthesis inhibitor. SGTC_609 0986-0026 86.3 µM -1.37658263545122 0.0790110769158831 no 3114 0.0843206612853146 4390 2848610 SGTC_822 1487-0950 154 µM -1.37759980920586 0.0788514203327186 no 3115 0.0841634399455744 4427 1958375 SGTC_2032 5185112 25.99 µM -1.38158465255569 0.0782283091577729 no 3116 0.0835496345189561 4291 5718189 SGTC_1508 1080-0625 72.9 µM -1.38194772488088 0.0781717215868416 no 3117 0.0834938763109114 4339 767111 SGTC_1141 3253-0389 52.6 µM -1.38219585724591 0.0781330661429327 no 3118 0.0834557858993628 4413 5402031 SGTC_255 tunicamycin 200.472 nM -1.38339612111904 0.0779462870202011 no 3119 0.083271719629774 4346 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_40 0327-0103 19.753 µM -1.38354199366001 0.0779236101671763 no 3120 0.0832493701870972 4262 409036 SGTC_2806 7952793 58.44 µM -1.38659397956348 0.0774503060672839 no 3121 0.0827828025803807 4448 2972490 SGTC_1917 st066507 28.5 µM -1.38801235268596 0.0772310882818365 no 3122 0.0825666418371964 4371 3156428 SGTC_3257 9139206 32.98 µM -1.38896196363067 0.0770845840755419 no 3123 0.0824221582993236 4437 4910041 SGTC_2667 digitoxin 100 µM -1.39022380433122 0.0768902365410784 no 3124 0.0822304635721018 4379 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_973 1325-0077 65.9 µM -1.39257286066943 0.0765294295533035 no 3125 0.0818744972980903 4436 2835149 SGTC_2285 7945142 200 µM -1.40362888428381 0.0748485378465858 no 3126 0.0802146946523253 4454 2970608 SGTC_607 4491-0986 66.8 µM -1.40597877312532 0.0744949316995695 no 3127 0.0798652140367817 4437 698981 YDR232W HEM1 SGTC_2732 terfenadine 20 µM -1.41957707656548 0.0724736830003821 no 3128 0.0778654214959433 4512 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_351 caspofungin 25 nM -1.42582474672677 0.0715592351742078 no 3129 0.0769594678970513 4438 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_420 mitomycin C 81.9 mM -1.43680873478269 0.0699730499449055 no 3130 0.0753861738928761 4434 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1642 st009582 77.7 µM -1.43775583686488 0.0698375570548914 no 3131 0.0752516720090917 4439 6739311 SGTC_1809 st050081 57.6 µM -1.43997802589396 0.0695204423414124 no 3132 0.0749368080397841 4517 5036894 SGTC_2069 5228469 200 µM -1.44118852210043 0.0693481671272919 no 3133 0.0747657150702397 4468 2835210 SGTC_680 0417-1641 114 µM -1.44192413536938 0.0692436369787945 no 3134 0.0746618883147548 4482 2835990 SGTC_2598 perillyl alcohol 100 µM -1.44614251874336 0.0686465499637083 no 3135 0.0740686160685333 4477 10819 An apoptosis inducer. SGTC_779 1360-0071 233 µM -1.45340622095666 0.0676277317814477 no 3136 0.0730555001264181 4495 7566 SGTC_1346 1488-2224 62.4 µM -1.45495569923792 0.0674119190525229 no 3137 0.0728407631300813 4489 3722427 SGTC_2045 5106652 78.05 µM -1.45962290032834 0.0667650828441006 no 3138 0.0721968709642062 4460 673349 SGTC_2344 7990960 76.95 µM -1.46144816390408 0.0665134264255027 no 3139 0.071946245591677 4453 140813 SGTC_228 caffeine 993.056 µM -1.46186522193525 0.0664560281511221 no 3140 0.0718890734522571 4464 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_165 k038-0023 64.381 µM -1.46317027209848 0.0662766662774105 no 3141 0.0717103965381692 4455 46368543 SGTC_2136 5328288 199.296 µM -1.46430057312246 0.0661216245230275 no 3142 0.0715559203283011 4447 262395 SGTC_2980 9014342 25.29 µM -1.46702571222951 0.0657489764872596 no 3143 0.0711845304660785 4507 2996599 SGTC_3235 9132602 49.47 µM -1.46948517643851 0.065414057592689 no 3144 0.0708506197843721 4465 4912240 SGTC_105 0111-0055 734.78 µM -1.4706291525422 0.0652587275963642 no 3145 0.0706957177656119 4489 5179370 SGTC_1418 3966-3099 2.4 µM -1.47429443978245 0.0647629787280495 no 3146 0.0702011657987635 4483 740335 SGTC_1695 st026914 34.495 µM -1.47871673306146 0.0641687393892767 no 3147 0.0696080191092205 4470 3289191 SGTC_1421 4029-0249 71.4 µM -1.48187672115246 0.0637467231868253 no 3148 0.0691865500787385 4553 2894095 SGTC_2540 epiandrosterone 100 µM -1.4825745607482 0.0636538184495353 no 3149 0.0690937400839408 4518 441302 A steroid. SGTC_1650 st011916 45.8 µM -1.48315091247423 0.0635771670895559 no 3150 0.0690171598772263 4441 242528 SGTC_2278 7948257 134.34 µM -1.48394243210528 0.0634720167503576 no 3151 0.0689120968094771 4491 1247028 SGTC_2424 5537928 59.2 µM -1.48554236813163 0.0632598847586093 no 3152 0.0687001043889502 4491 5382802 SGTC_312 4092-0653 6.84 µM -1.48847209205693 0.0628728704348726 no 3153 0.0683132183707987 4379 1148278 SGTC_1629 st005085 44.9 µM -1.49025936216483 0.062637680894764 no 3154 0.0680780266182484 4449 24207091 SGTC_2658 polymyxin b sulfate 77.05 µM -1.4923986618898 0.0623570695355732 no 3155 0.0677973328135283 4505 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2184 6075246 200 µM -1.49651859126591 0.0618194224679389 no 3156 0.0672592834303147 4479 2267320 SGTC_3200 9114385 49.47 µM -1.49788089850372 0.0616424408727547 no 3157 0.067082098664201 4466 17018030 YLR208W SEC13 SGTC_909 3448-9333 149 µM -1.50505285850956 0.0607172250685957 no 3158 0.0661552437706907 4425 3344074 SGTC_3254 9136651 49.47 µM -1.50606957781099 0.0605869472254128 no 3159 0.0660246566517619 4467 16454030 SGTC_1781 st038725 66.3 µM -1.51654723310756 0.0592570930553327 no 3160 0.0646905182191303 4493 4270275 YIL048W NEO1 SGTC_411 enrofloxacin 100 µM -1.51796933251067 0.0590783739354548 no 3161 0.0645110649670733 4539 71188 A bacterial gyrase inhibitor. SGTC_2006 4011487 200 µM -1.52054277950121 0.0587560369432466 no 3162 0.0641873077623953 4466 45595294 SGTC_1438 4092-1045 4 µM -1.52633253950816 0.0580358874480299 no 3163 0.0634635344198425 4518 1351342 SGTC_2847 9005661 71.43 µM -1.52707699607006 0.0579437949476126 no 3164 0.0633709332033505 4543 2991449 SGTC_2137 5261020 140 µM -1.52900216682033 0.0577061755393282 no 3165 0.0631319533779213 4499 763655 SGTC_2199 6590217 200 µM -1.53515820045606 0.0569514901313631 no 3166 0.0623724865017115 4470 703109 SGTC_2736 butenafine 14.65 µM -1.53550930915532 0.0569086821095365 no 3167 0.0623293860936655 4462 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1395 3486-0190 4.35 µM -1.53603612842452 0.0568444985662437 no 3168 0.0622647598803318 4489 6748079 SGTC_361 000s-0510 1.45 µM -1.53680657135717 0.0567507364863531 no 3169 0.0621703418735357 4406 660 SGTC_592 k241-0073 46.5 µM -1.53920890401933 0.0564591571467773 no 3170 0.0618766522870082 4541 4230158 SGTC_214 4373-3496 70 µM -1.5396246645331 0.0564088149275728 no 3171 0.0618259348962259 4583 3779166 SGTC_1327 1436-0082 2.18 µM -1.54010554948203 0.0563506312718726 no 3172 0.0617673136463799 4535 15992205 SGTC_605 1315-0399 119 µM -1.54155568103346 0.0561754620632279 no 3173 0.0615908011541877 4587 24020461 SGTC_570 0987-0065 62.6 µM -1.54370872906165 0.0559161760934408 no 3174 0.0613294553428661 4380 3104428 SGTC_2409 alverine citrate 63.97 µM -1.54868587657944 0.0553204049797096 no 3175 0.0607286253198408 4534 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2104 5389443 200 µM -1.55248489230657 0.054869040231102 no 3176 0.0602731224181376 4530 2244536 SGTC_320 4092-0846 5.34 µM -1.55664521035514 0.0543780931982739 no 3177 0.0597773717855738 4493 1359356 SGTC_335 4077-0256 27.6 µM -1.55683642984878 0.0543556117452152 no 3178 0.0597546627604485 4457 3121989 SGTC_353 1988-1175 58.3 µM -1.55951352195298 0.054041640603272 no 3179 0.0594374433394889 4348 2788357 SGTC_2958 9077254 16.72 µM -1.56380332275905 0.0535415250124017 no 3180 0.0589318818688857 4534 16457351 SGTC_2782 7736369 71.43 µM -1.56408775433439 0.0535084953303412 no 3181 0.0588984806843648 4507 2950836 YOL077C BRX1 SGTC_1168 k815-0004 80.5 µM -1.56551219916276 0.0533433241585974 no 3182 0.0587314296220056 4521 642433 SGTC_2608 thymoquinone 42.66 µM -1.56716263256599 0.0531524541531029 no 3183 0.0585383411703568 4488 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1238 0333-0287 48.8 µM -1.57182261849223 0.052616455979135 no 3184 0.0579958472129079 4527 7226 SGTC_3208 9114115 49.47 µM -1.57572554699058 0.0521708442207015 no 3185 0.0575445336227687 4492 650895 SGTC_1451 4152-0210 104 µM -1.57685194347473 0.0520427982695058 no 3186 0.057414798182089 4560 659563 SGTC_1193 1488-0126 41.5 µM -1.57697939292885 0.0520283258690104 no 3187 0.0574001333859198 4511 1384710 SGTC_2761 levamisole 97.89 µM -1.57848381746182 0.0518577339043285 no 3188 0.0572272514634892 4534 26879 An alkaline phosphatase inhibitor. SGTC_3031 9088762 49.47 µM -1.58761817816057 0.050831479916714 no 3189 0.056186352554488 4518 205253 SGTC_2821 7996764 71.43 µM -1.58762213743133 0.0508310386209095 no 3190 0.0561859046375902 4523 2987135 SGTC_2870 9038528 12.99 µM -1.59087487451815 0.0504695216978254 no 3191 0.0558188690420318 4556 6463316 SGTC_3250 9135583 49.47 µM -1.59398528900013 0.050125741759985 no 3192 0.0554696649390683 4557 7699353 SGTC_882 0843-0131 351 µM -1.59522105113363 0.0499896778759302 no 3193 0.0553314064419026 4557 5425421 SGTC_1356 1502-0781 85.8 µM -1.59968669322589 0.0495004409188002 no 3194 0.0548340526598317 4553 567702 SGTC_2269 7935389 174.42 µM -1.60421629783387 0.0490081082537347 no 3195 0.0543331917485207 4553 97605 SGTC_3016 9080866 49.47 µM -1.61454501336542 0.0479000855409909 no 3196 0.0532046306925136 4532 17066299 SGTC_3305 9127027 53.8275 µM -1.61668677154334 0.0476728559935423 no 3197 0.0529729554051718 4508 41905295 SGTC_808 0711-0032 135 µM -1.61830090835003 0.0475021754944084 no 3198 0.0527988825205101 4526 4252555 SGTC_1804 st050076 49.1 µM -1.62378169717054 0.046926281643537 no 3199 0.0522112038225791 4585 3895976 SGTC_1616 st002734 56.1 µM -1.63588890089466 0.0456739608859551 no 3200 0.0509314206632757 4541 4026101 SGTC_2016 5121758 140 µM -1.63621995108632 0.0456400994510701 no 3201 0.0508967811707946 4487 2795203 SGTC_1558 st069300 45.6 µM -1.63987134286928 0.0452679545682325 no 3202 0.0505159602214803 4520 24208000 SGTC_2388 9080168 200 µM -1.64143465837778 0.0451093717008591 no 3203 0.0503536101927137 4583 15943073 SGTC_815 1582-0027 36.9 µM -1.65700837925553 0.0435538646688925 no 3204 0.048758890509693 4576 3128206 SGTC_2895 9054447 58.44 µM -1.66279561311212 0.0429869846577216 no 3205 0.0481766775393348 4632 2697450 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.66584487460679 0.042690705410931 no 3206 0.0478721577962282 4576 688669 SGTC_958 1222-0007 33 µM -1.66659292376388 0.0426182745044486 no 3207 0.0477976884566008 4613 7312461 SGTC_37 0566-0070 1.56 µM -1.66732145166702 0.042547829307792 no 3208 0.047725251667986 4499 1626686 SGTC_2380 9035439 200 µM -1.67018397949226 0.042271947761977 no 3209 0.0474414843408623 4614 6462575 SGTC_1071 trifluoperazine 6.31 µM -1.68434592970566 0.0409282836680574 no 3210 0.0460574169333921 4626 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_963 1269-2853 151 µM -1.68627820809918 0.0407476680125595 no 3211 0.0458711131717517 4580 3668223 SGTC_3248 9135562 49.47 µM -1.69164912613567 0.0402490280990617 no 3212 0.0453564468928406 4577 17650701 SGTC_210 3551-0445 56.827 µM -1.69256076563568 0.04016488490718 no 3213 0.0452695522325119 4564 2865180 YOR207C RET1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.69493492999827 0.0399464230182639 no 3214 0.045043882667661 4649 4213774 SGTC_2648 atorvastatin 78.68 µM -1.69819701203084 0.0396478342098169 no 3215 0.0447352921589744 4585 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2086 5274770 176.623 µM -1.69868691890713 0.0396031486210126 no 3216 0.044689094724982 4616 689278 SGTC_1719 st032227 49.2 µM -1.70028614333546 0.0394575645041971 no 3217 0.0445385577866196 4572 3125804 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.70447749328021 0.0390780732157361 no 3218 0.0441459586541828 4466 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_409 arachidonic acid 100 µM -1.70579910441808 0.0389590305281327 no 3219 0.0440227449688946 4611 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_146 3448-8650 53.125 µM -1.70627277612572 0.0389164370122991 no 3220 0.0439786521623734 4558 2891488 YIL048W NEO1 SGTC_2221 6807166 181.081 µM -1.70650401851691 0.0388956570096026 no 3221 0.0439571393805332 4585 674925 SGTC_1732 st034308 51.822 µM -1.70669754292168 0.0388782733831225 no 3222 0.0439391420762472 4482 830119 SGTC_2555 cholic acid 100 µM -1.70985853200133 0.0385952273590462 no 3223 0.0436460181147708 4562 6708657 Influences liver metabolism. SGTC_2225 6654152 15.4 µM -1.71242553677877 0.038366606258372 no 3224 0.0434091381566032 4545 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_46 0329-0187a 2.197 µM -1.71667408812658 0.0379906508413698 no 3225 0.043019368578012 4585 46494817 SGTC_2700 st077718 96.8 µM -1.719936724685 0.037703984106291 no 3226 0.0427219720065083 4570 904970 SGTC_725 1497-0963 19 µM -1.72079111822062 0.0376292065341511 no 3227 0.0426443673511229 4644 3549977 SGTC_2224 6650123 117.647 µM -1.73276380342365 0.0365940220250831 no 3228 0.041568829432651 4635 2908370 SGTC_2882 9058044 58.44 µM -1.73506538757805 0.0363977166982355 no 3229 0.0413646120709732 4608 18076804 SGTC_3160 9100216 49.47 µM -1.73640494458807 0.0362838613394162 no 3230 0.0412461292970053 4599 17191039 SGTC_2122 5258151 111.688 µM -1.73647364352192 0.0362780301565571 no 3231 0.0412400603541167 4622 2173356 SGTC_1772 st048439 82.2 µM -1.75078882107855 0.0350795846464367 no 3232 0.0399911464560197 4648 2927068 YDL195W SEC31 SGTC_340 k038-0059 454 µM -1.75159564343407 0.0350130174563656 no 3233 0.0399216811162194 4602 23733424 SGTC_2022 5136654 200 µM -1.75319091327763 0.0348817042287158 no 3234 0.0397846211188183 4583 1713771 SGTC_2721 ifenprodil 61.44 µM -1.75629595566614 0.034627274661472 no 3235 0.0395189437462444 4590 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1499 4480-0877 67.3 µM -1.76086379047279 0.0342557550723966 no 3236 0.0391307299191464 4622 2861909 SGTC_3080 9117754 49.47 µM -1.76088305769702 0.0342541949615415 no 3237 0.039129099023591 4616 9550191 SGTC_2078 5212016 200 µM -1.76421838918075 0.0339850044050695 no 3238 0.0388476089271105 4529 1899708 SGTC_2130 NSC 7 2.4545 µM -1.78296550908043 0.0325041376732193 no 3239 0.0372959590205843 4651 21448 SGTC_1752 st044819 83.042 µM -1.78794726185439 0.0321196990635672 no 3240 0.0368922584070093 4561 441209 YML126C ERG13 SGTC_410 α-linolenic acid 100 µM -1.79286841426453 0.0317436302444911 no 3241 0.0364969834601209 4651 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_514 4466-0038 2.65 nM -1.79597622429012 0.0315080145501413 no 3242 0.0362491492003141 4432 5722064 SGTC_2698 st077697 67.5 µM -1.79632138950671 0.0314819355997355 no 3243 0.0362217089918305 4592 3154499 SGTC_2261 9010538 184.68 µM -1.79670891381649 0.0314526774746033 no 3244 0.0361909215548226 4592 6457250 SGTC_665 3914-0008 307 µM -1.80527039757119 0.0308119978348263 no 3245 0.0355161897816199 4599 1069549 SGTC_1050 3232-1156 69.3 µM -1.81069560458573 0.0304116345771496 no 3246 0.0350939918146289 4593 700529 SGTC_2541 muurolladie-3-one 83.07 µM -1.82080617437024 0.0296770073902525 no 3247 0.0343181627077983 4564 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.82851909966926 0.0291265455589701 no 3248 0.0337358409275209 4618 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2362 9071156 126 µM -1.8384847473519 0.0284278962907373 no 3249 0.0329955036859109 4621 653133 SGTC_1529 apigenin 74 µM -1.84728521296404 0.0278225801889577 no 3250 0.0323529074533393 4635 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2466 5983409 37.09 µM -1.8608889739425 0.0269080370145681 no 3251 0.0313799285849534 4646 2879657 SGTC_1359 1582-0056 520 nM -1.8656031590691 0.0265970287979508 no 3252 0.0310484536626068 4693 3661189 SGTC_1776 st049249 45.9 µM -1.87249375754825 0.0261478433419944 no 3253 0.0305691623638424 4662 1822314 SGTC_1066 ketoconazole 628 nM -1.88136277808576 0.0255790419434282 no 3254 0.029961293290351 4689 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1972 st070201 17.4 µM -1.88344796165495 0.0254468265809329 no 3255 0.0298198428922095 4660 2829099 SGTC_36 0335-0881 14.2 µM -1.88357414865259 0.0254388438351588 no 3256 0.0298113006849468 4572 23828853 SGTC_2005 4024620 188 µM -1.88701043816127 0.0252222648179053 no 3257 0.0295794608550711 4605 236743 SGTC_1955 wogonin 32.4 µM -1.89039375939563 0.0250105359212974 no 3258 0.029352658716303 4626 5281703 A flavanone. SGTC_1008 4106-0037 6 µM -1.89250062937178 0.0248794419715647 no 3259 0.0292121549351632 4676 2905394 SGTC_473 2-arachidonoylglycerol 10 µM -1.89523475129997 0.0247101786234983 no 3260 0.0290306540607247 4527 5282280 An endocannabinoid. SGTC_1862 st057513 3.81 µM -1.8972222658468 0.0245877433465355 no 3261 0.0288993046826403 4661 5393163 SGTC_3136 9095672 49.47 µM -1.89746018941528 0.0245731209067303 no 3262 0.0288836141253153 4529 17217380 SGTC_2283 7944793 200 µM -1.90009511734603 0.0244116694039277 no 3263 0.0287103191777827 4628 2970533 SGTC_1405 3909-7894 12 µM -1.90021123540472 0.0244045749685731 no 3264 0.0287027022139563 4656 7104060 SGTC_895 0964-0006 13.7 µM -1.90429531155916 0.0241561500255642 no 3265 0.0284358672500555 4661 6738897 SGTC_3002 9075603 71.4286 µM -1.907434649753 0.023966638355571 no 3266 0.0282321630023251 4609 20105405 SGTC_3258 9138477 49.47 µM -1.92032764606106 0.0232013820430221 no 3267 0.027408263213038 4697 4970355 SGTC_639 0833-0042 114 µM -1.92696887508312 0.0228152901966295 no 3268 0.026991754478238 4683 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2017 5132927 60.65 µM -1.93421518654222 0.0224002117963653 no 3269 0.0265433379760433 4627 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1663 st014140 55.4 µM -1.93773085005921 0.022201135730632 no 3270 0.0263280340430054 4712 4207120 SGTC_1056 3448-1962 115 µM -1.94514396627596 0.0217862540924635 no 3271 0.0258788267876003 4629 715507 SGTC_1893 st059353 36.1 µM -1.9521479653426 0.0214003045285512 no 3272 0.0254603199641216 4664 3112488 SGTC_935 2996-0153 430 µM -1.96642667755425 0.0206313705668981 no 3273 0.0246246721671543 4668 23738523 SGTC_912 3474-0017 2.18 µM -1.9734703338907 0.0202607589571791 no 3274 0.0242210006202894 4676 3360550 SGTC_641 4092-0595 30 µM -1.97932495760978 0.0199570199658781 no 3275 0.0238897156979647 4703 786260 SGTC_2203 7227154 166.4 µM -1.98494834197063 0.0196689239328162 no 3276 0.0235751095798483 4697 896304 SGTC_839 0122-0028 230 µM -1.98884972686494 0.0194711302394089 no 3277 0.0233588960853544 4692 759448 SGTC_163 TUB2.036 7.546 µM -1.9955599746338 0.0191348838441104 no 3278 0.0229909199421787 4629 15992207 YJR013W GPI14 SGTC_796 1234-0020 70.7 µM -2.0050513683972 0.0186677142990074 no 3279 0.0224787778605491 4651 46495034 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.01044035820695 0.0184068132624564 no 3280 0.0221923013240703 4708 688788 SGTC_2712 st079126 47.7 µM -2.01150601487231 0.0183555903398174 no 3281 0.0221360178191008 4688 3152970 SGTC_71 0417-1750 47.813 µM -2.01598865750029 0.018141450768958 no 3282 0.0219005809321513 4644 6811472 SGTC_1729 st035615 45.989 µM -2.01747499370474 0.0180709189305816 no 3283 0.0218229840251185 4663 17385451 SGTC_2534 helenine 20.12 µM -2.0182794478998 0.018032842367101 no 3284 0.0217810829561318 4681 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2377 9073351 62.6 µM -2.02229120185818 0.0178439768808856 no 3285 0.0215731385102197 4677 7337946 YHR072W ERG7 SGTC_780 0109-0199 192 µM -2.03780613063379 0.0171293641754835 no 3286 0.0207846625149571 4693 610414 SGTC_1874 staurosporine 7.6 µM -2.05308780453016 0.0164495471843727 no 3287 0.0200320312629672 4696 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2370 9071495 200 µM -2.05464920956781 0.0163814056103828 no 3288 0.0199564494842671 4710 21791103 SGTC_96 0929-0093 37.281 µM -2.06235415967026 0.0160486808851314 no 3289 0.0195870150966897 4714 6991579 SGTC_2464 5717415 7.67 µM -2.07664223351061 0.0154469893343013 no 3290 0.0189172959309196 4663 5285744 SGTC_1973 st070275 50.2 µM -2.07981972969998 0.0153158443971612 no 3291 0.018771035375045 4712 17118334 SGTC_2585 alliin 100 µM -2.08112346995942 0.0152623123671888 no 3292 0.0187113030579524 4667 87310 A garlic compound which reacts with lipids. SGTC_2789 5281112 71.43 µM -2.08181853541026 0.0152338384720397 no 3293 0.0186795240234056 4692 765948 SGTC_1058 3448-5425 97.3 µM -2.08610240338901 0.0150593518566002 no 3294 0.0184846740261461 4670 7279705 SGTC_1741 st038134 10.228 µM -2.09529217036261 0.0146908290076638 no 3295 0.0180725140298212 4693 1272587 SGTC_2132 5317594 122.667 µM -2.10217689767819 0.0144198496165247 no 3296 0.0177688913718903 4659 794577 SGTC_1882 5615643 20 µM -2.10422704938214 0.0143399928298348 no 3297 0.0176793230356869 4710 2253075 SGTC_1248 0469-0687 58.6 µM -2.12054514102435 0.0137178473000627 no 3298 0.0169800494516353 4674 4017482 SGTC_950 1165-0508 94.1 µM -2.12371225004722 0.0135998345088032 no 3299 0.016847106207488 4685 6148369 SGTC_1004 4084-0029 199 µM -2.13050427687574 0.0133497011363316 no 3300 0.0165650015473517 4714 716894 YLR208W SEC13 SGTC_3028 9087778 49.47 µM -2.13581135954704 0.0131570292671764 no 3301 0.016347396424963 4685 17217395 SGTC_138 0850-0259 40.9225 µM -2.13899051544126 0.0130427657647131 no 3302 0.0162182182588356 4651 6813004 SGTC_2088 5278280 127.392 µM -2.15570727279066 0.0124559515765712 no 3303 0.0155532649635965 4731 791502 SGTC_2085 5307070 144.047 µM -2.15938765285455 0.0123298731812381 no 3304 0.0154100524972091 4673 2840351 SGTC_2004 4023728 41.89 µM -2.16345580730801 0.0121917986628767 no 3305 0.0152530696139667 4675 360084 YDR527W RBA50 SGTC_691 1548-0686 185 µM -2.16812329706807 0.012035035070594 no 3306 0.0150746533634677 4715 46495133 SGTC_1673 st016611 27.3 µM -2.18293362128907 0.0115491275370565 no 3307 0.0145203493242017 4714 5226799 SGTC_1253 0550-0034 176 µM -2.18460517980417 0.0114953707408417 no 3308 0.0144589039091247 4697 5969915 SGTC_1464 k208-0027 110 µM -2.19181767579234 0.0112659036564211 no 3309 0.0141963371405783 4714 X1464 SGTC_1446 4239-0190 62 µM -2.19487662423702 0.0111697913779138 no 3310 0.0140862245291191 4727 1340085 SGTC_3097 9117246 49.47 µM -2.2201985758625 0.0104011855478598 no 3311 0.0132026454763444 4738 16423892 SGTC_1276 0871-0068 94.2 µM -2.23485759729995 0.00997764414771006 no 3312 0.0127133495495308 4731 3414906 SGTC_1783 st039459 87.517 µM -2.25654409473278 0.00937868343713456 no 3313 0.0120182885183762 4750 729761 SGTC_929 2805-0021 398 µM -2.27044129738057 0.00901160559278729 no 3314 0.0115904106049477 4733 3098024 SGTC_1486 3970-0793 4.53 µM -2.27539029086797 0.00888395624913446 no 3315 0.0114412636471458 4764 2844330 SGTC_2690 usnic acid 100 µM -2.27654494148164 0.00885440331720618 no 3316 0.0114067069807002 4717 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2944 9067346 25.62 µM -2.27766024681372 0.00882593925468687 no 3317 0.0113734139842381 4659 6473075 SGTC_1250 0485-0349 40.2 µM -2.29419423309277 0.00841328100608019 no 3318 0.0108896722106825 4707 6842794 YDL195W SEC31 SGTC_623 k072-0108 16.9 µM -2.33045127244872 0.00756719054314057 no 3319 0.00989115628219585 4740 5382803 SGTC_3001 9076041 71.4286 µM -2.34004773157764 0.00735618563073096 no 3320 0.00964063774829673 4734 16004211 SGTC_3049 9092223 49.47 µM -2.35578582437542 0.00702135390562773 no 3321 0.00924178560274631 4725 8623917 SGTC_486 niguldipine 82 µM -2.35664149767602 0.00700354108595272 no 3322 0.00922052025582916 4780 1236 A calcium channel blocker. SGTC_1534 6-azauridine 81.6 µM -2.36402140101997 0.00685155951419544 no 3323 0.00903888412855159 4766 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2713 st079149 53.4 µM -2.3648641607212 0.00683439041960156 no 3324 0.00901834259966977 4756 3103253 SGTC_696 1560-0013 611 µM -2.36716122063105 0.00678778644436805 no 3325 0.00896256124122088 4751 1650269 SGTC_2749 bexarotene 57.39 µM -2.36852946772955 0.00676016033988643 no 3326 0.00892947883031455 4723 82146 An retinoic acid receptor inhibitor. SGTC_159 3970-0959 50 µM -2.40321176449536 0.00609228471838177 no 3327 0.00812588659043417 4739 6615653 SGTC_1364 1653-0028 37.6 µM -2.42460112251706 0.00571016546152434 no 3328 0.00766260729274978 4775 5718652 SGTC_282 k297-0036 65.7 µM -2.45107036636241 0.00526684536693974 no 3329 0.00712160531913148 4757 5061378 SGTC_2726 cimetidine 79.27 µM -2.46198320403931 0.00509316975943605 no 3330 0.00690855685547138 4781 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2349 9023730 187.07 µM -2.50320856894303 0.0044821902137394 no 3331 0.00615364962464463 4758 4126287 SGTC_3008 9078912 71.4286 µM -2.55003441921724 0.00386830078911785 no 3332 0.00538561422296666 4767 16648731 SGTC_1054 3429-0080 167 µM -2.55265844700271 0.00383624279431293 no 3333 0.00534521362946371 4750 1162877 SGTC_1479 0549-0158 134 µM -2.58656470208065 0.00344290509423583 no 3334 0.0048468984374269 4791 5440202 SGTC_2539 epi(13)torulosol 80 µM -2.6141444144204 0.00315010594551093 no 3335 0.00447256090942958 4740 6708597 SGTC_2185 6113692 200 µM -2.62698439265367 0.00302159797539186 no 3336 0.00430726425641554 4757 874150 SGTC_2296 7971656 126.45 µM -2.63018258906115 0.00299033274198809 no 3337 0.00426695098588361 4751 666570 SGTC_773 4358-1457 44.6 µM -2.63360506160374 0.00295719815568547 no 3338 0.00422418468884445 4770 1186886 SGTC_3041 9091929 49.47 µM -2.67798032719949 0.00255655212257967 no 3339 0.00370337842527983 4744 25236887 SGTC_1286 0929-0070 131 µM -2.67798960154408 0.00255647378480658 no 3340 0.00370327588384565 4786 1420408 SGTC_368 fentichlor 4.58 µM -2.6811673853584 0.00252975932176649 no 3341 0.00366829041025864 4760 7329 A pesticide. SGTC_991 3996-0057 64.7 µM -2.70347845069952 0.00234919447239775 no 3342 0.00343089485660118 4771 715343 SGTC_2951 9072950 58.06 µM -2.70837868279933 0.0023111339776904 no 3343 0.00338064131931724 4740 16488155 SGTC_2177 5811945 192 µM -2.81637670789225 0.00160211858196425 no 3344 0.00242843403450199 4767 5343475 SGTC_2176 5809774 33.9695 µM -2.82171068929989 0.00157288473872064 no 3345 0.00238841243747556 4777 2870539 SGTC_806 3966-4455 5.86 µM -2.83152504755926 0.00152036264723565 no 3346 0.00231633025055047 4783 714982 SGTC_2709 st078560 56 µM -2.83384936929316 0.00150816051968388 no 3347 0.00229955024241857 4777 17250903 SGTC_1950 st077106 7.18 µM -2.8455389959511 0.00144813638463882 no 3348 0.00221681652082962 4756 13831864 SGTC_946 3434-1334 87.4 µM -3.15204288887721 0.000474113928023144 yes 3349 0.000810662284941603 4796 4047976 SGTC_1570 verbenone 133 µM -3.24759574104012 0.000327960799800627 yes 3350 0.000581922503728821 4792 29025 A natural terpanoid with antifungal properties. SGTC_2012 4023501 200 µM -3.36733641563796 0.000203822108380024 yes 3351 0.000379490197998462 4793 3477460 SGTC_3278 9139605 49.47 µM -3.40673591400691 0.000173708189265587 yes 3352 0.00032872352872297 4798 7958859 SGTC_2787 5284540 71.43 µM -3.66688567493979 5.79635482248479e-05 yes 3353 0.000122761248941314 4790 736958 SGTC_2790 5423970 71.43 µM -3.8222818942618 2.90585978844184e-05 yes 3354 6.6111206193415e-05 4796 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_914 3820-6779 408 µM -3.82981584080497 2.80832200501665e-05 yes 3355 6.41195968114607e-05 4791 2893481 SGTC_2960 9079389 5.97 µM -4.18319981062048 5.28232991927091e-06 yes 3356 1.43717275996809e-05 4803 16457355