SGTCid condition conc unit PEA2|YER149C.score PEA2|YER149C.strain.pval PEA2|YER149C.strain.significant PEA2|YER149C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1252 0493-0875 34.8 µM 11.0553726149005 2.54366404179415e-28 yes 1 1.03238825526726e-28 1 3960963
SGTC_1234 0326-0494 15.5 µM 10.7839981571715 4.73417196038692e-27 yes 2 2.04841448826396e-27 1 1547813
SGTC_138 0850-0259 40.9225 µM 5.06245522179344 2.01620094450966e-07 yes 3 2.06945648755706e-07 142 6813004
SGTC_699 0375-0592 111 µM 4.45253352628516 3.97975282814341e-06 yes 4 4.2431492287402e-06 11 762578
SGTC_873 0591-4978 488 µM 4.39128859190155 5.26713302419757e-06 yes 5 5.63404311521143e-06 11 3305145
SGTC_135 0933-0004 26.348 µM 4.19924098354126 1.2399575872309e-05 yes 6 1.33905591566465e-05 17 21230617 YGL099W LSG1
SGTC_565 1418-0001 44.5 µM 3.88435305206708 4.68678744266033e-05 yes 7 5.1301362633281e-05 20 2862145
SGTC_2130 NSC 7 2.4545 µM 3.8439741134162 5.52129591324e-05 yes 8 6.0528890567487e-05 29 21448
SGTC_206 4546-0025 72.014 µM 3.70333256799047 9.65631170925188e-05 yes 9 0.00010639281876473 84 6620745 YIL048W NEO1
SGTC_3354 9151612 71.43 µM 3.6376675343071 0.000124580200296291 yes 10 0.00013755911778201 19 27261949
SGTC_1129 3453-1384 223 µM 3.63125354381044 0.000127691933907745 yes 11 0.000141023961708208 51 1084452
SGTC_2831 7999036 19.48 µM 3.54555700037387 0.000176905987422758 yes 12 0.000195892121811901 59 2988270
SGTC_2525 harmine 47.85 µM 3.5251588335266 0.000190990071403246 yes 13 0.00021161447267793 17 5280953 A monoamine oxidase inhibitor
SGTC_935 2996-0153 430 µM 3.50947435267302 0.000202524962103594 yes 14 0.00022449667940535 31 23738523
SGTC_577 r071-0003 38.6 µM 3.44799702311257 0.000254307126541462 yes 15 0.000282380130919738 82 4568517 YMR134W ERG29
SGTC_767 0929-0023 86 µM 3.39399218946412 0.000309727478297061 yes 16 0.000344408285480509 114 1204563
SGTC_1621 st003705 32.4 µM 3.29428766607046 0.000442601884249466 yes 17 0.000493357307034343 42 24207032
SGTC_312 4092-0653 6.84 µM 3.24629963286707 0.000523874359584168 yes 18 0.00058457857704211 121 1148278
SGTC_2246 7293507 91.5585 µM 3.23839367413362 0.000538519708388274 yes 19 0.000601024084789585 60 887656
SGTC_1799 st045822 46.1415 µM 3.22309401913242 0.000567942605118285 yes 20 0.000634069610236439 34 3674992
SGTC_913 3487-1245 167 µM 3.18828465572852 0.000640505361993461 yes 21 0.000715597842074189 70 4016153
SGTC_1202 1988-0068 29.6 µM 3.15071446223666 0.000728359531318932 yes 22 0.000814358165693057 60 2850480
SGTC_255 tunicamycin 200.472 nM 3.14817568978572 0.000734679482040161 yes 23 0.000821464579112321 124 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2320 7373003 200 µM 3.11510729562687 0.000821747205121104 yes 24 0.000919390053297378 55 5415828
SGTC_58 0957-0393 9 µM 3.10468386633939 0.000851100285748873 yes 25 0.000952412476675272 480 6997992
SGTC_649 1123-0311 367 µM 3.05029914522517 0.00102050553367965 no 26 0.0011430676786553 125 693629 YIL048W NEO1
SGTC_1987 st072290 61.9 µM 3.02532590797916 0.00110822038363418 no 27 0.00124182670619439 49 54697379
SGTC_3162 9099653 49.47 µM 3.02136159854394 0.0011227634772799 no 28 0.00125820324952061 20 25237511
SGTC_2238 6671620 73.2395 µM 3.01776760384619 0.00113609898269396 no 29 0.00127322050998846 71 729941
SGTC_2285 7945142 200 µM 3.01159064724613 0.00115935801523734 no 30 0.00129941398095541 63 2970608
SGTC_2547 epiafzelechin trimethyl ether 100 µM 3.00977779097322 0.00116626655113029 no 31 0.00130719441222104 16 6708630 An antioxidant.
SGTC_446 go6976 132 µM 2.99259091953975 0.00123366120894505 no 32 0.00138310129246647 50 3501 A protein kinase C inhibitor.
SGTC_321 4534-3890 65.3 µM 2.99039250298697 0.00124253424271877 no 33 0.00139309588669546 24 699746
SGTC_1201 1889-3372 45.9 µM 2.98634111658935 0.0012590391597131 no 34 0.00141168754900678 35 5392199
SGTC_1388 3346-4487 254 µM 2.97859966626506 0.00129113591956622 no 35 0.00144784419197795 69 3345614
SGTC_631 k072-0230 41.5 µM 2.97243458785214 0.00131723016664562 no 36 0.00147724078994679 66 5773147
SGTC_261 5-fluorouridine 15.376 µM 2.9477467294388 0.00142662544252598 no 37 0.00160049599716776 59 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_916 4466-0038 42 nM 2.92664777591904 0.00152662401314265 no 38 0.00171318341854333 156 5722064 YGL116W CDC20
SGTC_2690 usnic acid 100 µM 2.90401396857466 0.00164097031154217 no 39 0.00184205861284353 87 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2444 5485484 36.41 µM 2.90320257674208 0.00164521069716993 no 40 0.00184683814303323 93 6790631
SGTC_1379 2144-0755 36.5 µM 2.85301255313353 0.00192774697515939 no 41 0.0021653455397952 74 5392327
SGTC_1781 st038725 66.3 µM 2.8373949127787 0.00202426143378117 no 42 0.00227416582676083 176 4270275 YIL048W NEO1
SGTC_2054 5233173 129 µM 2.83543475486822 0.00203667977012499 no 43 0.00228816808130433 137 6889
SGTC_2696 st077691 74.316 µM 2.82836521558793 0.00208204447479396 no 44 0.00233931989309152 93 757133
SGTC_1230 0170-0365 3.77 µM 2.80968069889775 0.00220638853969654 no 45 0.0024795336051068 174 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3166 9102297 49.47 µM 2.71269176900704 0.00296663979072773 no 46 0.00333695763108938 104 25237072
SGTC_1915 st067105 30.6 µM 2.71018411387675 0.00298910245970664 no 47 0.00336229343729853 130 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_208 k072-0098 12.366 µM 2.70780763405244 0.00301053142557589 no 48 0.00338646336593578 137 5948901
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.69548796977468 0.00312385338098714 no 49 0.00351428078903766 124 6728940
SGTC_690 glyoxal 20.3 µM 2.67591908749406 0.00331176672630139 no 50 0.00372623172626304 178 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1399 3562-5772 25 µM 2.64419124005524 0.00363811169126637 no 51 0.00409431882534689 63 23847490
SGTC_1859 st055998 20 µM 2.62771494018481 0.00381872207242024 no 52 0.00429802581901457 88 676301
SGTC_1259 0671-0132 43 µM 2.62169890127561 0.0038866459704045 no 53 0.00437463458211911 111 X1259
SGTC_1626 st003712 1.76 µM 2.61676377553203 0.00394317196634538 no 54 0.00443838746746956 111 24207035
SGTC_80 0159-0065 512.242 µM 2.60842835807323 0.00404031819347888 no 55 0.00454795248129035 36 1548079
SGTC_694 1315-0438 43.2 µM 2.60237265892757 0.00411223314426289 no 56 0.00462905950161576 68 6793154
SGTC_2084 5306078 60.6385 µM 2.59615186723828 0.00418729932165007 no 57 0.00471371931670043 96 679340
SGTC_2794 7785382 27.27 µM 2.58404588941598 0.00433690418305719 no 58 0.00488244004796317 141 2205081
SGTC_1189 1431-2119 7.28 µM 2.56858097502323 0.00453495903532996 no 59 0.00510579257051766 141 3107275
SGTC_2854 9024559 71.43 µM 2.56149576970868 0.00462836500605146 no 60 0.00521112552641642 114 3163529
SGTC_2210 7115885 190.385 µM 2.55442327115921 0.00472331187130175 no 61 0.00531819347470472 117 2927039
SGTC_2763 lisinopril 49.32 µM 2.5530939334707 0.00474135068165172 no 62 0.00533853483960334 60 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2983 9022671 12.99 µM 2.54305914581747 0.00487951469850032 no 63 0.0054943313268686 92 6405161
SGTC_2094 5332512 191.667 µM 2.54104442879047 0.00490768300496275 no 64 0.00552609371342999 118 755774
SGTC_2045 5106652 78.05 µM 2.53503743731413 0.00499253040511877 no 65 0.00562176546473878 77 673349
SGTC_2808 7946468 45.46 µM 2.52206369848899 0.00518025393527814 no 66 0.00583342897718745 127 2970879
SGTC_1872 amphotericin b 148 nM 2.51922647286361 0.00522213474014327 no 67 0.00588064906539688 113 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_571 k831-0106 44.2 µM 2.51553498737042 0.00527707626756837 no 68 0.00594259400104714 101 4783639
SGTC_1492 4158-0558 28.5 µM 2.48695054381006 0.0057202034127179 no 69 0.00644216545024602 112 3967268
SGTC_1790 st045711 43.5 µM 2.47278005639822 0.00595188833114971 no 70 0.00670333121737913 98 585119
SGTC_57 miconazole 162.5 nM 2.41724168301304 0.0069421238288295 no 71 0.00781931483369347 133 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1736 st036774 51 µM 2.41452488716679 0.00699409452001701 no 72 0.00787787328352396 136 1272247
SGTC_3216 9129716 49.47 µM 2.41301675060142 0.007023092263583 no 73 0.00791054622462846 128 8056934
SGTC_2960 9079389 5.97 µM 2.41099607461175 0.0070621111835076 no 74 0.00795450983268146 141 16457355
SGTC_907 3448-6986 75.5 µM 2.4106455903862 0.00706889840959344 no 75 0.00796215710212093 148 590582
SGTC_31 0508-1974 57.237 µM 2.40848589513602 0.00711084867613746 no 76 0.00800942263174915 123 6810525
SGTC_1377 2944-0135 198 µM 2.40809748677617 0.00711841644164212 no 77 0.00801794917746698 163 1894137
SGTC_2257 7960413 200 µM 2.38865870711419 0.00750635499854519 no 78 0.00845500146477912 188 2974689 YIL048W NEO1
SGTC_887 0885-0007 9.62 µM 2.3739639858291 0.00781185886447934 no 79 0.00879913344136307 162 5719458
SGTC_1266 0828-0227 32.9 µM 2.36640731165687 0.00797318107333053 no 80 0.00898083560755961 137 3913820
SGTC_408 cantharidin 100 µM 2.36318029848539 0.00804296015451601 no 81 0.00905942611037496 151 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1332 1480-0653 17.5 µM 2.35355083624107 0.00825438309252335 no 82 0.00929753252138655 142 5749438
SGTC_393 acivicin 6.25 µM 2.33831227643003 0.00859893790751899 no 83 0.00968552731827514 114 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_801 0866-0028 10.1 µM 2.33335486154497 0.00871371663193938 no 84 0.00981476413244568 175 6849771
SGTC_2335 9018011 154.17 µM 2.32757570523422 0.00884921504183476 no 85 0.00996732236844677 159 6458208
SGTC_402 epigallocatechin gallate 10 µM 2.3260093990407 0.00888625533117136 no 86 0.0100090246362446 173 65064 An antioxidant.
SGTC_986 1493-0483 84 µM 2.31830351980152 0.00907047048798439 no 87 0.0102164156314717 123 40079
SGTC_2765 myclobutanil 7.74 µM 2.30128001544634 0.00948932532621589 no 88 0.010687904307317 175 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1762 st045503 25.4615 µM 2.28516044885162 0.00990143008079888 no 89 0.0111517106907093 155 4645554
SGTC_3325 9138760 55.175 µM 2.26520585334195 0.0104331587120977 no 90 0.0117500250605395 161 43844959
SGTC_1510 1123-0200 71.5 µM 2.26353780147305 0.0104787140273973 no 91 0.0118012785517979 209 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2431 5490079 200 µM 2.2606333168214 0.0105584507075681 no 92 0.0118909864331415 181 5722345
SGTC_780 0109-0199 192 µM 2.25178612029369 0.0108045985222781 no 93 0.0121678956101287 175 610414
SGTC_3133 9127736 49.47 µM 2.24507292000546 0.0109946929618692 no 94 0.0123817258626756 145 27243420
SGTC_2327 6189656 200 µM 2.24432609342786 0.0110160192735303 no 95 0.0124057139326561 145 5349088
SGTC_2289 7946404 165.07 µM 2.23839002244966 0.0111868126238681 no 96 0.0125978160601134 257 1246120 YPR165W RHO1
SGTC_1364 1653-0028 37.6 µM 2.22317273803318 0.0116351999949449 no 97 0.0131020771869396 171 5718652
SGTC_1346 1488-2224 62.4 µM 2.2195232367163 0.0117450265063589 no 98 0.013225574082849 135 3722427
SGTC_2379 9035213 200 µM 2.19710574744694 0.0124395842850624 no 99 0.0140064473712079 161 646551
SGTC_443 clozapine 122 µM 2.19230911753427 0.0125927333744818 no 100 0.0141785969283691 105 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_813 k007-0158 173 µM 2.18600583703598 0.0127964672004969 no 101 0.0144075891429926 213 6523916
SGTC_2619 obliquin 87.91 µM 2.18551375047311 0.0128124916816347 no 102 0.014425599432047 339 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3105 9121040 49.47 µM 2.18513027247832 0.0128249914264819 no 103 0.0144396480999796 57 41448907
SGTC_2432 5630864 12.22 µM 2.18382648207924 0.0128675683549782 no 104 0.0144875004312081 198 5714970
SGTC_2567 aureobasidin a 60 nM 2.18213840990585 0.0129228760603869 no 105 0.0145496595895081 284 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_840 0245-0196 390 µM 2.15991347273937 0.0136704404643793 no 106 0.0153896842951516 179 3827528
SGTC_2108 5365811 200 µM 2.15971667903523 0.0136772231303976 no 107 0.0153973046038816 181 780283
SGTC_1383 3049-0032 20.7 µM 2.15414431513988 0.0138704882738144 no 108 0.015614428089141 186 712864
SGTC_2252 omeprazole 400 µM 2.14554854998517 0.0141732306111302 no 109 0.0159545070105026 99 4594 A proton pump inhibitor.
SGTC_1922 5578187 25 µM 2.13954574183748 0.0143880100745158 no 110 0.0161957477574094 209 1350412
SGTC_3081 9117243 49.47 µM 2.13404555619062 0.0145872602204064 no 111 0.0164195259307063 167 45595589
SGTC_2692 st077426 47.7 µM 2.11622226807104 0.0152493249545312 no 112 0.0171629540905436 188 25238571
SGTC_1531 st059297 52.4 µM 2.11038040691039 0.0154718702870511 no 113 0.0174128013679507 190 7566702
SGTC_919 tnp00227 403.569 nM 2.1029482864604 0.015759021353402 no 114 0.0177351451209338 221 1269246 A methoxyflavone. YNL221C POP1
SGTC_1374 2889-5571 141 µM 2.09477859138598 0.0160799322251258 no 115 0.0180953395381896 239 2853281
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.08800956104477 0.016350050929843 no 116 0.018398486116092 193 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_586 0957-0265 8.15 µM 2.07470048435389 0.0168924951427932 no 117 0.0190071512368249 148 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2745 rifampicin 24.3 µM 2.0734222350727 0.0169453942102498 no 118 0.0190665007015031 92 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1742 st038235 28.8875 µM 2.07047511299747 0.0170678978724751 no 119 0.0192039371214846 297 564103 YBR002C RER2
SGTC_1522 st012842 45.6 µM 2.06715480097582 0.017206820036948 no 120 0.0193597848373712 205 3491067 YOR116C RPO31
SGTC_3202 9113761 49.47 µM 2.06361153631938 0.0173561350272737 no 121 0.0195272814552 255 4798415
SGTC_2391 6285546 200 µM 2.06139550988699 0.0174500808852824 no 122 0.0196326614396227 241 846083
SGTC_1972 st070201 17.4 µM 2.05744512463759 0.0176186299311061 no 123 0.019821714163295 197 2829099
SGTC_797 k781-0471 270 µM 2.05311074005399 0.0178051595850128 no 124 0.0200309192852876 201 23738129
SGTC_1759 st043059 70 µM 2.04676799315431 0.0180811537564724 no 125 0.0203404348404184 206 669426
SGTC_3029 9088683 49.47 µM 2.04356608868092 0.0182218590815456 no 126 0.0204982161209287 200 25236615
SGTC_1009 4106-0057 9.87 µM 2.03228068863101 0.0187252509636985 no 127 0.0210626241628969 200 2928005
SGTC_1650 st011916 45.8 µM 2.01547849165397 0.0194966244728671 no 128 0.0219272687296893 166 242528
SGTC_1071 trifluoperazine 6.31 µM 2.01381244152989 0.0195745616328819 no 129 0.0220146144946015 220 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1754 st042065 16.137 µM 2.01260050418619 0.0196314216734577 no 130 0.0220783369469827 424 1126236 YIL048W NEO1
SGTC_1562 morin hydrate 59.1 µM 2.01017415928342 0.0197456791808188 no 131 0.0222063796676537 203 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1948 st076329 66.6 µM 2.00480365956794 0.0200005868721732 no 132 0.0224920205847834 209 24208413
SGTC_657 3534-0529 86.7 µM 2.00424169678404 0.0200274207414785 no 133 0.0225220879854261 207 1049549
SGTC_2764 methyldopa 94.69 µM 1.9869555479789 0.0208678825303212 no 134 0.0234636615496311 230 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_54 0159-0055 9 µM 1.98593524654529 0.0209184096993127 no 135 0.0235202572106705 219 3319099
SGTC_711 k292-0785 179 µM 1.98196714337528 0.0211159029507881 no 136 0.0237414590731845 220 4146315
SGTC_1497 4476-2978 41.3 µM 1.97261410052498 0.021587654682824 no 137 0.0242697726370918 271 1528379
SGTC_883 0850-0245 24.6 µM 1.96359180175406 0.0220511334464614 no 138 0.0247887244499716 265 6823229 YPR165W RHO1
SGTC_2430 5571206 200 µM 1.95943739853954 0.022267354744209 no 139 0.0250307922415782 272 1731771
SGTC_3096 9117468 49.47 µM 1.94767848653703 0.0228890812774461 no 140 0.0257267229341362 137 41316311
SGTC_651 3253-0966 34.4 µM 1.94606498931691 0.0229755217554623 no 141 0.0258234667369356 255 781462
SGTC_1568 digitonin 820 nM 1.93948451418073 0.0233309126573334 no 142 0.0262211841896453 263 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2288 7946289 167.31 µM 1.93935049334147 0.0233381985077667 no 143 0.0262293371952625 280 1246052
SGTC_1547 harmine 94.2 µM 1.93810058517867 0.0234062402178705 no 144 0.0263054760451733 313 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1343 1487-0095 224 µM 1.93497234529016 0.0235772653643718 no 145 0.0264968446883797 198 4560101 YGL055W OLE1
SGTC_2741 miltefosine 3.04 µM 1.9312039445539 0.0237846835469455 no 146 0.0267289181997226 178 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1487 3970-0795 2.82 µM 1.93001450092453 0.0238504699095054 no 147 0.0268025205221924 232 3765103
SGTC_351 caspofungin 25 nM 1.92656465256161 0.0240421416168837 no 148 0.0270169536701329 374 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_42 0133-0086 60.653 µM 1.92326978908882 0.0242264091212202 no 149 0.0272230883103155 222 162923 Model of phenazepam hydroxylation.
SGTC_1176 0848-0131 83.3 µM 1.9209444702024 0.0243571669044216 no 150 0.0273693542733343 281 6769040
SGTC_807 1315-0151 48 µM 1.91933472873461 0.0244480328635019 no 151 0.02747099279182 279 4011080
SGTC_2625 euphol 100 µM 1.91929585693401 0.0244502305952 no 152 0.0274734510300768 282 6708538 A triterpene alcohol.
SGTC_1573 oleylamine 1.06 µM 1.89706081783694 0.0257348226349005 no 153 0.0289099558726632 277 5356789 An amine of the fatty acid oleic acid.
SGTC_467 ro 31-8220 72.8 µM 1.88947609579396 0.0261857408240416 no 154 0.0294140314351676 317 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1246 0422-0085 105 µM 1.88743230207048 0.0263083698644089 no 155 0.0295511019240471 297 264295
SGTC_938 3126-1755 342 µM 1.886338630168 0.026374187871778 no 156 0.0296246683862243 242 1777771
SGTC_2174 5790901 200 µM 1.87930469758336 0.0268007919870916 no 157 0.0301014503241393 282 786020
SGTC_1331 1472-0049 76.2 µM 1.86675048897416 0.0275765155621458 no 158 0.0309682197453618 282 24051409
SGTC_3006 9075424 71.4286 µM 1.86621336690495 0.0276101175159857 no 159 0.0310057598376152 246 7465181
SGTC_1567 st069303 68.4 µM 1.85937927971366 0.0280406404533257 no 160 0.0314866983328892 282 5581319
SGTC_2131 toluylene red 5.2905 µM 1.8558037404337 0.0282681050195378 no 161 0.0317407686211988 291 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1818 st052136 56.3 µM 1.85473117580428 0.0283366369121099 no 162 0.0318173122449019 296 674169
SGTC_2219 9098279 200 µM 1.850411850338 0.0286140228139937 no 163 0.0321271061576456 239 902349
SGTC_2638 epoxomicin 18 µM 1.84093944301285 0.0292302506296545 no 164 0.0328152167203732 285 9915668 A protesome inhibitor.
SGTC_319 1348-1596 45.5 µM 1.82902509815935 0.030020950963974 no 165 0.033697924233818 272 5380505
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.82794162392645 0.0300937277172516 no 166 0.0337791566125015 345 368090
SGTC_3210 9128157 49.47 µM 1.81764182256805 0.030792894638456 no 167 0.0345594475042574 317 17590849
SGTC_1693 xanthone 101.9 µM 1.81571185983343 0.0309253881394795 no 168 0.0347072919123881 298 7020 An insecticide.
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.81439998278942 0.0310157186457136 no 169 0.0348080842040634 170 88881 An O-methylated flavonoid and antioxidant.
SGTC_2693 st077581 40.7 µM 1.81214371247421 0.0311715868300496 no 170 0.0349819968227137 366 25238761
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.80671657291398 0.0315491608393317 no 171 0.0354032411547972 137 4000243
SGTC_2766 oltipraz 83.91 µM 1.806418336362 0.031570018692262 no 172 0.0354265097699014 268 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1345 1488-0192 31.4 µM 1.8028724595703 0.0318188821103366 no 173 0.035704123554347 283 658348
SGTC_1283 0922-0125 16.4 µM 1.80009453290984 0.0320149780043193 no 174 0.0359228563596865 299 3360884
SGTC_2052 5265182 7.135 µM 1.79990524611183 0.0320283761357379 no 175 0.0359378005853763 299 1239884
SGTC_1417 3966-0327 90.4 µM 1.78850307917818 0.032844026375684 no 176 0.0368474396582591 309 651118
SGTC_1971 st069429 63.5 µM 1.78526639232732 0.0330786572026233 no 177 0.0371090586991728 244 1246522 YGL099W LSG1
SGTC_2968 9090663 33.37 µM 1.78216837224463 0.0333045277911622 no 178 0.0373608893881929 314 25236811
SGTC_2127 5253358 187.912 µM 1.78184590382069 0.0333281111463526 no 179 0.0373871821051064 270 20612
SGTC_1590 st077108 57.8 µM 1.77483829405643 0.0338440104443893 no 180 0.0379622956713472 238 5489485
SGTC_394 menadione 8.33 µM 1.76381924009984 0.0346685046187886 no 181 0.0388812085645043 298 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2429 5902844 64.44 µM 1.76227589936374 0.0347852903343634 no 182 0.0390113468948729 338 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2576 guaiol 23.12 µM 1.757084721598 0.0351804832204679 no 183 0.03945168475822 319 227829
SGTC_2439 5492030 7.2 µM 1.75670935246209 0.0352092014730735 no 184 0.0394836812986033 272 5722370
SGTC_276 colchicine 750 µM 1.756271758941 0.0352427045832306 no 185 0.0395210085026842 327 2833 A microtubule depolymerizer.
SGTC_3024 9090631 49.47 µM 1.74878139616327 0.0358202490982058 no 186 0.040164406895469 236 25236383
SGTC_489 paxilline 115 µM 1.74867375061473 0.0358286052973296 no 187 0.0401737149609153 282 105008 A toxic potassium channel blocker.
SGTC_487 nimodipine 119 µM 1.74820528110858 0.0358649897740764 no 188 0.0402142437323051 193 4497 L-type voltage-gated calcium channels inhibitor
SGTC_130 0136-0219 337.655 µM 1.74729271088786 0.0359359530039773 no 189 0.0402932884151577 306 234244
SGTC_1482 3346-2049 8.48 µM 1.74208707756097 0.0363429556309495 no 190 0.0407466042145046 289 3826804
SGTC_964 1287-0107 19.4 µM 1.74020878904372 0.0364907328249918 no 191 0.0409111814506476 339 51516812 YPR165W RHO1
SGTC_1690 st023502 41.2 µM 1.73921363625649 0.0365692270220577 no 192 0.0409985958725247 272 24207482
SGTC_1529 apigenin 74 µM 1.7336493323935 0.0370106692976275 no 193 0.0414901608240823 349 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_245 methotrexate 289.6 µM 1.73309013311067 0.0370552730554734 no 194 0.0415398249115693 347 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1039 k821-0043 94 µM 1.73082365458654 0.0372365057098717 no 195 0.0417416107942959 308 15992768
SGTC_2452 5863136 48.41 µM 1.72821991695096 0.0374455995650888 no 196 0.0419744021234869 315 2184096
SGTC_3061 glucosamine 200 µM 1.71619317400551 0.0384238887365671 no 197 0.0430633460715391 273 91431 and experimental redox chemotherapeutic
SGTC_281 1672-3440 14.9 µM 1.71175237735493 0.0387903412511477 no 198 0.0434711558295366 319 6833000
SGTC_3213 9129884 49.47 µM 1.70973748563162 0.0389575454945497 no 199 0.0436572138233847 274 17190742
SGTC_1691 st019933 84.6 µM 1.70468052379245 0.0393797794722294 no 200 0.0441270120835437 283 6176082
SGTC_1338 1486-1223 76 µM 1.70243422978419 0.0395685256673302 no 201 0.0443369989584844 334 3444526
SGTC_1507 4075-3230 155 µM 1.70237530845761 0.0395734864525799 no 202 0.0443425178309409 251 659771
SGTC_740 k014-0057 261 µM 1.70153491514701 0.0396442970743184 no 203 0.0444212936378243 362 4012779
SGTC_1654 st012436 41.8 µM 1.69976036796877 0.0397941569757032 no 204 0.0445880045209314 276 4323132
SGTC_1026 k007-1105 30.6 µM 1.69661224317964 0.0400611480357652 no 205 0.0448849967964217 418 7066794
SGTC_1718 roemerine 11.9335 µM 1.69494606853048 0.0402030435153055 no 206 0.0450428260633496 391 235224 An aporphine alkaloid with mutagenic activity.
SGTC_199 4063-0024 41.6 µM 1.69142518135563 0.0405042337705734 no 207 0.0453778131306392 285 306215
SGTC_2518 prenyletin 46.28 µM 1.68262764457346 0.0412648210036256 no 208 0.0462235983175521 219 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2278 7948257 134.34 µM 1.68129686640012 0.0413808745628703 no 209 0.0463526331297782 299 1247028
SGTC_1647 st011722 22.4 µM 1.67442261589262 0.0419845784039034 no 210 0.0470237855633547 300 2854783
SGTC_3018 9082602 49.47 µM 1.67298736636331 0.0421115188808325 no 211 0.0471648915694005 347 17332089
SGTC_1796 st049173 110.4 µM 1.65979449951514 0.0432929669475163 no 212 0.0484779003401405 262 94134
SGTC_3322 9139058 2.11 µM 1.65174218898205 0.0440271258401526 no 213 0.0492935591309142 344 4908926 YPR165W RHO1
SGTC_287 k060-0039 29.6 µM 1.64252761389336 0.044879535019668 no 214 0.0502403541281151 322 5861974
SGTC_2545 solidagenone 89.61 µM 1.64168785004659 0.0449578748527917 no 215 0.0503273554517263 177 6708572 An anti ulcer agent
SGTC_1212 0520-0165 585 µM 1.6369310438369 0.0454037074093287 no 216 0.0508224392728681 370 5403258
SGTC_985 1493-0307 8.71 µM 1.63369278635697 0.0457092429542306 no 217 0.0511616869045905 290 3278274
SGTC_2008 4012253 172 µM 1.63234333998328 0.0458370525760751 no 218 0.0513035889913211 395 603940
SGTC_848 0368-0089 85.6 µM 1.62547934351773 0.0464916117881095 no 219 0.0520302308732394 362 762535
SGTC_1078 idebenone 36.1 µM 1.62422263803898 0.0466122614175225 no 220 0.0521641505348397 425 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2568 diosmetin 100 µM 1.6231338863433 0.0467169897007443 no 221 0.0522803935646071 379 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3194 9111903 49.47 µM 1.62273806934487 0.0467551105546016 no 222 0.0523227048084498 368 17087251
SGTC_10 0279-0212 42.575 µM 1.62214609220405 0.046812170018237 no 223 0.0523860355182584 487 39851 YBR002C RER2
SGTC_3230 9131665 49.47 µM 1.62032860149556 0.0469877033010721 no 224 0.0525808540503573 185 15943720
SGTC_862 0452-0056 10.2 µM 1.61752271873094 0.0472597315045065 no 225 0.0528827478599202 335 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2742 clothiapine 36.27 µM 1.61508694183178 0.0474969003897645 no 226 0.053145934187952 288 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2339 9000433 200 µM 1.61259114655343 0.0477409012791881 no 227 0.0534166816086093 336 2988954
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.61182677888308 0.0478158299717453 no 228 0.0534998195816386 371 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2598 perillyl alcohol 100 µM 1.6081397659182 0.0481785803113374 no 229 0.053902285820389 375 10819 An apoptosis inducer.
SGTC_72 0744-0168 198.391 µM 1.60800276949315 0.0481921011478566 no 230 0.0539172861128448 361 677577
SGTC_1418 3966-3099 2.4 µM 1.60617420647053 0.0483728616861139 no 231 0.0541178194868996 389 740335
SGTC_2859 9028643 45.46 µM 1.6056009061121 0.0484296461774804 no 232 0.0541808131308616 328 17151580
SGTC_1709 st033179 39.1045 µM 1.60507160336706 0.0484821200931512 no 233 0.0542390238668477 393 573381
SGTC_362 0310-0100 9.03 µM 1.60161858179093 0.0488255617707555 no 234 0.054619989606944 397 790235
SGTC_2286 7945697 125 µM 1.59634744819898 0.0493535814197392 no 235 0.0552056210466096 416 1245733
SGTC_2029 5175081 200 µM 1.59454730747482 0.0495349457874213 no 236 0.0554067518840142 404 1380876
SGTC_2906 7926292 26.41 µM 1.59411564951779 0.0495785143439787 no 237 0.0554550671972969 389 2966319
SGTC_465 cgp-37157 41 µM 1.59271407024046 0.0497201909124548 no 238 0.0556121748207163 243 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3311 9131146 2.8755 µM 1.59082318575086 0.0499118398066955 no 239 0.0558246867225121 428 4900406 YPR165W RHO1
SGTC_1682 st012968 530 nM 1.58318322114871 0.05069218792635 no 240 0.0566898548240361 344 24207270
SGTC_2522 biochanin a 4.94 µM 1.58225709117297 0.0507874398308447 no 241 0.0567954459741045 336 5280373 A possible chelator.
SGTC_1450 4112-4260 37.6 µM 1.58217678812885 0.0507957056600074 no 242 0.056804608883746 384 1633175
SGTC_3107 9121808 49.47 µM 1.57901776348871 0.0511217241664995 no 243 0.0571659913339538 281 662681
SGTC_723 4182-0001 115 µM 1.57796689250809 0.0512305447831213 no 244 0.057286607958727 361 744821 YLR208W SEC13
SGTC_501 nsc-95397 161 µM 1.57207919220238 0.051843645452901 no 245 0.0579660932408167 336 262093
SGTC_1267 0828-0272 9.49 µM 1.57112947920872 0.0519430853183713 no 246 0.058076288211219 423 745334
SGTC_2671 danthron 100 µM 1.57074159501271 0.0519837423648488 no 247 0.0581213416393058 377 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_39 0986-0283 58.349 µM 1.56853561765884 0.0522154483792017 no 248 0.0583780921968633 446 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2986 9022445 71.43 µM 1.56627109492537 0.0524541561341342 no 249 0.0586425824603004 381 6459286
SGTC_1411 3909-8223 150 µM 1.56388660316237 0.0527064455699304 no 250 0.0589221006001778 394 X1411
SGTC_2133 5320837 200 µM 1.56149010610425 0.0529609743774594 no 251 0.0592040782342635 384 2841355
SGTC_735 3076-0345 636 µM 1.56143721115668 0.0529666032569141 no 252 0.0592103138972938 449 2888990
SGTC_2669 eugenol 100 µM 1.55609927207671 0.0535370906191077 no 253 0.0598422440474231 308 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.55359777276971 0.0538061060238542 no 254 0.0601401954594866 358 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1606 st000094 49.2 µM 1.53955343439563 0.055336386800542 no 255 0.0618346217450655 409 1242210
SGTC_1140 3229-1848 2.98 µM 1.53386926932498 0.0559654236892687 no 256 0.0625309087510676 351 2849525
SGTC_2277 7947813 106.88 µM 1.53202344284935 0.056170900498536 no 257 0.0627583249475819 404 1246798
SGTC_1480 1070-0044 41.2 µM 1.53155777342951 0.0562228325207454 no 258 0.0628157997267409 399 3124987
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.52831888149398 0.0565850857129555 no 259 0.0632166920878003 402 16623 A steroid.
SGTC_808 0711-0032 135 µM 1.52044404681537 0.0574735169374972 no 260 0.0641997056662307 397 4252555
SGTC_959 1222-0044 107 µM 1.51999309996259 0.0575247226346436 no 261 0.0642563549141783 411 6083612
SGTC_784 4579-0127 173 µM 1.51906127873787 0.0576306460279982 no 262 0.0643735360669727 427 1948547
SGTC_1697 st025554 27.742 µM 1.51595872683911 0.0579844299012393 no 263 0.0647648945318796 371 1269519
SGTC_2292 7671323 168.05 µM 1.51224767903507 0.0584098399190957 no 264 0.065235432896869 432 937504
SGTC_2161 5662504 8.5105 µM 1.51168558807758 0.0584744875171088 no 265 0.0653069333377672 399 2859334
SGTC_859 0439-0102 54.6 µM 1.51027076934075 0.0586374583411206 no 266 0.0654871735991356 437 610143
SGTC_2002 4023503 131 µM 1.51004989230534 0.0586629329785257 no 267 0.065515346921164 521 4736863 YCR052W RSC6
SGTC_2908 7930301 100 µM 1.50810787761315 0.0588872874979012 no 268 0.0657634596863904 458 2223178
SGTC_524 r073-0010 27.8 µM 1.5067846544492 0.0590405403542773 no 269 0.0659329321178373 401 2772106
SGTC_2075 5212009 200 µM 1.50517672298964 0.0592271884006225 no 270 0.0661393239603625 363 780898
SGTC_278 4092-0821 23.9 µM 1.50163404953024 0.0596400532115714 no 271 0.0665958223551646 400 877900
SGTC_1923 st058458 19.1 µM 1.49953074703807 0.059886237946706 no 272 0.0668679991767044 485 3534982
SGTC_547 1120-0019 610 nM 1.48951443241095 0.0610695520929997 no 273 0.0681759778711436 434 3676939
SGTC_2263 7948595 193.29 µM 1.48941421923441 0.061081482817335 no 274 0.0681891632580095 352 2971371
SGTC_3257 9139206 32.98 µM 1.48774837488925 0.0612800742867262 no 275 0.0684086324476341 328 4910041
SGTC_3168 9103419 49.47 µM 1.484375809686 0.0616836744836953 no 276 0.0688546243028954 295 16649256
SGTC_822 1487-0950 154 µM 1.48331833232014 0.0618106509605501 no 277 0.0689949269655157 418 1958375
SGTC_2435 5706476 10.6 µM 1.48092503992569 0.0620987786546307 no 278 0.0693132748222446 456 5725375
SGTC_2744 captopril 92.04 µM 1.47426618204282 0.0629059512124595 no 279 0.0702049683706065 327 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3131 9127911 49.47 µM 1.47374950009686 0.0629689224406802 no 280 0.07027452487365 435 45595681
SGTC_3040 9091894 49.47 µM 1.47143396714993 0.0632517341053378 no 281 0.0705868965270084 379 25236966
SGTC_1952 st077036 64.1 µM 1.4697810400906 0.0634542214827504 no 282 0.0708105328903734 470 2937007
SGTC_1219 1469-0211 33.1 µM 1.4620650828212 0.0644061253963436 no 283 0.0718616879989946 413 6822282
SGTC_3176 9106582 49.47 µM 1.46011823226838 0.0646480491801095 no 284 0.0721287912989755 261 17018027
SGTC_2650 prasterone 100 µM 1.46008375262091 0.0646523401169463 no 285 0.0721335286742101 333 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_56 0957-0365 83.25 µM 1.45862169631564 0.0648344943128676 no 286 0.0723346293248698 457 6752360
SGTC_279 1273-0055 2.93 µM 1.45861231277788 0.0648356646715758 no 287 0.0723359213831792 483 2847562
SGTC_602 3130-1533 38.1 µM 1.45782618455025 0.0649337725237768 no 288 0.0724442294596077 498 720941
SGTC_2380 9035439 200 µM 1.45461844075898 0.0653352899898686 no 289 0.072887461459842 504 6462575
SGTC_2311 7694451 200 µM 1.45021999071362 0.065888977451083 no 290 0.0734985910717686 448 2163142
SGTC_1365 1672-3266 55.4 µM 1.44981979371657 0.0659395351495862 no 291 0.073554389156709 479 6415873
SGTC_3235 9132602 49.47 µM 1.44919158236923 0.0660189589893323 no 292 0.0736420438157718 483 4912240
SGTC_449 xestospongin c 11.1929 µM 1.44861477818719 0.0660919487494813 no 293 0.0737225959097658 479 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_358 0075-0058 9.45 µM 1.44769916507012 0.0662079403174311 no 294 0.0738506017784628 572 1069125
SGTC_1170 0310-0127 64.8 µM 1.4476539033005 0.066213678249471 no 295 0.0738569339328986 465 774975
SGTC_2496 diffractaic acid 79.83 µM 1.44754166239982 0.0662279089320727 no 296 0.0738726383066624 487 94870 An apoptosis inducer which activates caspases.
SGTC_2915 7971052 15.16 µM 1.44493537447942 0.0665590188069949 no 297 0.0742380194674668 308 5741558
SGTC_2708 st078559 56 µM 1.43668336365226 0.0676158314844793 no 298 0.0754039920899817 341 17250902
SGTC_1282 0886-0010 32.4 µM 1.4309080262713 0.0683631423385868 no 299 0.0762282882157266 504 2836211 YNL267W PIK1
SGTC_623 k072-0108 16.9 µM 1.43059914050334 0.0684032900344524 no 300 0.0762725669750411 471 5382803
SGTC_538 2922-0838 53.3 µM 1.42630942272453 0.0689627321733238 no 301 0.0768895229519746 548 777039
SGTC_1698 5-fluorocytosine 1.055 µM 1.42608581435053 0.0689919904109608 no 302 0.0769217864931582 423 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_590 k048-0076 22.4 µM 1.41816778602078 0.0700342115923002 no 303 0.0780708922606175 461 6832814
SGTC_110 0850-0284 111.64 µM 1.41664820123486 0.0702356072555028 no 304 0.0782929042225601 331 3906265
SGTC_1892 st058411 7.36 µM 1.41644053601517 0.0702631643820424 no 305 0.0783232813444838 543 3934738
SGTC_1077 5-fluorocytosine 377 nM 1.41506600670254 0.0704457738090932 no 306 0.0785245719206311 441 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_548 1436-0017 110 µM 1.41463291569017 0.0705033864893901 no 307 0.0785880763636252 569 9677137
SGTC_1340 1486-1359 257 µM 1.41221632535662 0.070825522717284 no 308 0.0789431375047599 467 4309068
SGTC_1407 3909-7909 12.3 µM 1.41028075582608 0.0710843525510212 no 309 0.0792283992870749 485 4411780
SGTC_1998 st075797 76.8 µM 1.4085137031446 0.0713212815430875 no 310 0.0794895061097438 514 24208315
SGTC_1226 3909-7979 35.4 µM 1.39689562529019 0.0728941718868747 no 311 0.0812224801687483 547 6615510
SGTC_3027 9089541 49.47 µM 1.39460769764253 0.0732070245408478 no 312 0.0815670862781218 499 9943819
SGTC_2970 9090938 41.86 µM 1.39334208353885 0.0733805261615495 no 313 0.0817581852120769 578 17217104
SGTC_1716 st033144 30.6155 µM 1.39194545616309 0.0735723530872137 no 314 0.0819694577185823 520 674617
SGTC_1644 st010134 20.9 µM 1.39035116575947 0.07379179744541 no 315 0.0822111339110507 462 3818134
SGTC_2825 7998094 58.44 µM 1.39018554441928 0.0738146228677551 no 316 0.0822362709526148 479 2987815
SGTC_3014 9081533 49.47 µM 1.38687295837 0.0742722873615907 no 317 0.0827402524708392 496 21367265
SGTC_3238 9133470 49.47 µM 1.38528341399067 0.0744926656119847 no 318 0.0829829116478146 463 3534688
SGTC_1032 k061-1018 98.7 µM 1.38395285491199 0.0746775210271967 no 319 0.0831864454994449 574 4005393
SGTC_3321 9137793 26.8275 µM 1.38311824214213 0.0747936528421507 no 320 0.0833143065401773 512 4904192
SGTC_3183 9108214 49.47 µM 1.38297969249334 0.0748129445986288 no 321 0.0833355463656824 333 4974831
SGTC_1882 5615643 20 µM 1.37996015884158 0.0752343302979743 no 322 0.0837994560617091 444 2253075
SGTC_1134 3477-0009 42.5 µM 1.37651743673586 0.075716978282845 no 323 0.084330746356519 544 3973534
SGTC_658 3253-0951 102 µM 1.37633992704421 0.075741927818552 no 324 0.0843582085072073 611 1184878
SGTC_798 1287-0182 476 µM 1.37423824616214 0.0760378017370349 no 325 0.0846838653894297 542 1649755
SGTC_3284 9108171 64.8615 µM 1.36819383943095 0.0768936357491473 no 326 0.0856257047265059 461 8687505
SGTC_541 4513-1321 94 µM 1.36688710176985 0.0770796171327476 no 327 0.0858303477340458 502 747515
SGTC_2467 5474540 200 µM 1.35492401473537 0.0787981841541415 no 328 0.0877208837722165 515 5413519
SGTC_1695 st026914 34.495 µM 1.35232514871615 0.0791753360310018 no 329 0.0881356613541075 516 3289191
SGTC_1837 st055472 66.5 µM 1.35151817348711 0.0792927233181982 no 330 0.0882647511653192 509 676091
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.35050675568868 0.0794400359967991 no 331 0.0884267440720299 547 688664
SGTC_1997 st073024 93.8 µM 1.34988812647277 0.0795302411792634 no 332 0.0885259354409036 496 686268
SGTC_221 trifluoperazine 10.304 µM 1.34854404281887 0.0797264953384439 no 333 0.0887417322505025 691 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1768 st044301 37.178 µM 1.34764279012799 0.0798582952997928 no 334 0.0888866504206055 527 3931349
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.34726085642931 0.0799141992958698 no 335 0.0889481171039383 427 77254
SGTC_1648 st011736 69.8 µM 1.3466917978807 0.0799975478211013 no 336 0.0890397575010565 506 2855514
SGTC_1454 4239-0054 42.6 µM 1.34656821551931 0.0800156572920049 no 337 0.0890596683171729 566 1340767
SGTC_1744 st037937 38.9 µM 1.34538171743293 0.0801896817152668 no 338 0.0892509981232344 514 1016152
SGTC_3214 9129694 49.47 µM 1.34398658019424 0.0803946731514893 no 339 0.0894763632495877 479 17158655
SGTC_3127 9126946 49.47 µM 1.34319759155688 0.0805107766096274 no 340 0.0896040006660637 452 27243249
SGTC_1011 4112-3381 17.4 µM 1.34220772915657 0.0806566186908877 no 341 0.0897643255412266 527 2877139
SGTC_1916 st067606 49.2 µM 1.34127520223727 0.0807941956469955 no 342 0.0899155589556809 566 19590279
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.33702080361069 0.0814241017030297 no 343 0.0906079231266933 493 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_305 1682-2595 20.8 µM 1.33558215936928 0.0816379432123161 no 344 0.0908429423142287 540 226033
SGTC_2520 obtusaquinone 4.71 µM 1.33532781192222 0.0816757936764935 no 345 0.0908845399233968 510 5967872
SGTC_1241 0364-0022 50.8 µM 1.33295433824617 0.0820296378048493 no 346 0.0912733944448793 548 4563895
SGTC_2998 9066762 71.4286 µM 1.32466290877718 0.0832748144465444 no 347 0.0926414902756347 590 4945196
SGTC_1291 0993-0025 5.79 µM 1.32157887160094 0.0837415719721318 no 348 0.0931542114145009 528 4353356
SGTC_595 3909-8003 73.7 µM 1.31698002995415 0.0844412358814631 no 349 0.0939226592786072 527 699517
SGTC_3084 9116877 49.47 µM 1.31266094236984 0.085102323547647 no 350 0.09464861210073 443 27241325
SGTC_2009 4012297 12.05 µM 1.31130588603934 0.0853105282981444 no 351 0.0948772202929462 518 45595307
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.30359024845813 0.0865033155949956 no 352 0.0961866636470329 519 756377
SGTC_2955 9076254 12.21 µM 1.30178533316566 0.0867841346756296 no 353 0.096494889487184 510 16459619
SGTC_366 0181-0206 4.31 µM 1.29746665671093 0.0874588232808693 no 354 0.097235335257366 570 274874
SGTC_2220 6782180 200 µM 1.28981078738103 0.0886644764077042 no 355 0.0985581807945033 464 833803
SGTC_3012 9080433 71.4286 µM 1.28806632642839 0.0889409192472242 no 356 0.0988614379447202 574 17688859
SGTC_2076 5212012 200 µM 1.27768031088918 0.090600074072048 no 357 0.100681085142481 454 604802
SGTC_69 0096-0274 206.684 µM 1.27547801147812 0.0909548226278705 no 358 0.101070051049449 638 6741392
SGTC_3177 9107506 49.47 µM 1.27491985197801 0.0910448949663456 no 359 0.101168805856462 515 8897194
SGTC_2337 9009472 200 µM 1.27163754584338 0.0915759121398225 no 360 0.101750965066607 626 5742383
SGTC_2053 5265679 138 µM 1.27162686301905 0.0915776441647335 no 361 0.101752863776182 598 764595
SGTC_1874 staurosporine 7.6 µM 1.2711778588009 0.0916504639543704 no 362 0.10183269077454 588 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_995 3931-2021 34.6 µM 1.26988614409853 0.0918601943089281 no 363 0.102062594714079 541 730143
SGTC_1404 3909-7820 48.3 µM 1.2683983193136 0.0921022065288921 no 364 0.102327870762877 557 23741373
SGTC_453 enantio-paf c16 10 µM 1.26821810185629 0.0921315530429533 no 365 0.102360037175664 741 13871343 A lipid and platelet activating factor
SGTC_2670 beta-carotene 100 µM 1.26734743571805 0.0922734293639084 no 366 0.102515543049747 470 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_68 0986-0284 82.829 µM 1.26695255398652 0.0923378291949673 no 367 0.102586127736696 515 423278 YIL048W NEO1
SGTC_1571 st070080 73.4 µM 1.26685166967767 0.0923542873846722 no 368 0.102604166363458 565 4315245
SGTC_729 4092-0585 94.1 µM 1.26101906460709 0.0933095088578475 no 369 0.10365098924191 536 2169061
SGTC_2401 5128683 200 µM 1.25957015119112 0.0935479292134086 no 370 0.103912234448496 527 708373
SGTC_85 0868-0259 160.055 µM 1.25944281920459 0.093568903323389 no 371 0.103935215750224 554 83173
SGTC_1428 4049-0204 61.7 µM 1.25830958019807 0.0937557233258623 no 372 0.104139908903382 590 X1428
SGTC_3086 9117350 49.47 µM 1.25340981970915 0.0945666425391948 no 373 0.10502829980821 471 2679265
SGTC_1713 st033146 12.748 µM 1.24261472338101 0.0963714733972606 no 374 0.107004920857788 593 674619
SGTC_2060 5238662 140 µM 1.24210870066469 0.096456692131719 no 375 0.107098229405876 564 790130
SGTC_539 4859-0462 2.54 µM 1.24160800664231 0.0965410679519085 no 376 0.107190613106962 590 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1142 3253-1408 9.78 µM 1.24104214804998 0.0966364904118514 no 377 0.107295089559379 572 256655
SGTC_1263 0774-1208 64.8 µM 1.24062269030355 0.0967072695495367 no 378 0.107372582878033 673 906585
SGTC_809 3998-0021 90 µM 1.23671542774071 0.0973684094493279 no 379 0.108096374534572 560 715485
SGTC_2584 androsterone 48.74 µM 1.23618160274811 0.0974589937204327 no 380 0.108195533776646 755 2754130 A steroid.
SGTC_323 4013-0906 34.3 µM 1.22831512105672 0.0988010237992184 no 381 0.109664348404809 576 2910086
SGTC_633 0437-0093 97.7 µM 1.22636221832756 0.0991362766065175 no 382 0.110031198595873 572 2831118
SGTC_2791 5663188 71.43 µM 1.22430118218396 0.0994909940947875 no 383 0.110419315574457 555 54690634
SGTC_3111 9122088 49.47 µM 1.21962617713688 0.100299029003195 no 384 0.111303309172015 472 16876704
SGTC_3008 9078912 71.4286 µM 1.21933872798646 0.100348867999077 no 385 0.111357827597069 572 16648731
SGTC_844 0330-0132 15.3 µM 1.21626447882511 0.1008830233203 no 386 0.111942094123527 616 2828079
SGTC_11 0438-0307 1.3 µM 1.21622081101351 0.100890625570599 no 387 0.111950409028091 591 4011476
SGTC_311 1315-0136 58 µM 1.21574126368199 0.100974138775159 no 388 0.112041749970875 619 6759207
SGTC_2313 7726885 200 µM 1.21368927394741 0.101332062140886 no 389 0.112433200897971 600 726423
SGTC_167 3672-0051 66.205 µM 1.21204428139542 0.101619660835984 no 390 0.112747715261232 573 3237971
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.20997301570942 0.101982630835862 no 391 0.113144623738663 592 689007
SGTC_1687 st020778 55.3625 µM 1.2089699930707 0.102158739872504 no 392 0.113337186895031 760 4259299
SGTC_734 2023-0417 80 µM 1.20832334132146 0.102272395137062 no 393 0.113461456816603 610 3935732
SGTC_637 1181-0519 7.26 µM 1.20761157400585 0.102397601383723 no 394 0.113598352587674 710 6252091 YGR060W ERG25
SGTC_1464 k208-0027 110 µM 1.20578474137768 0.102719467703517 no 395 0.11395025019687 644 X1464
SGTC_1861 st057647 17.4 µM 1.20474674427082 0.102902677790498 no 396 0.114150542338359 645 688668
SGTC_2605 digitonin 300 nM 1.20334979180722 0.103149619338598 no 397 0.114420494217759 711 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_361 000s-0510 1.45 µM 1.20218383711923 0.103356056304408 no 398 0.114646155018964 636 660
SGTC_682 0kpi-0099 17 µM 1.19868794551211 0.10397681542705 no 399 0.115324653512013 656 1714895 YML126C ERG13
SGTC_1396 3511-0007 98.6 µM 1.19504886277505 0.104625868083086 no 400 0.116033969884531 559 X1396
SGTC_1946 st076057 65.1 µM 1.19483952964546 0.104663292990417 no 401 0.11607486630565 492 953009
SGTC_2477 5967686 25.23 µM 1.19036323658865 0.105465893461082 no 402 0.116951828014648 618 776118
SGTC_183 3914-0051 30.55 µM 1.18700590029971 0.106070779476162 no 403 0.11761264658624 618 1596232
SGTC_1665 st014639 11.4 µM 1.18661289586343 0.106141750016796 no 404 0.117690173418239 681 981133 YIL048W NEO1
SGTC_2743 auranofin 4.32 µM 1.18657039314638 0.106149427407143 no 405 0.117698559971375 596 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.18546919786454 0.106348479397508 no 406 0.117915993132553 677 688801
SGTC_805 3852-0218 479 µM 1.18513650105957 0.106408670638794 no 407 0.117981740631125 605 6615355
SGTC_2640 pentamidine 10.38 µM 1.18022039908339 0.107300956632367 no 408 0.118956283905185 695 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2262 9014885 67.46 µM 1.17600474634479 0.108070394848 no 409 0.11979648970062 535 6457424
SGTC_2994 9053520 71.4286 µM 1.17434572630107 0.108374284797787 no 410 0.120128287406772 644 4647384
SGTC_3218 9131285 49.47 µM 1.17091394024354 0.109004850524155 no 411 0.120816685578852 730 17156417
SGTC_2030 5175110 200 µM 1.16956447832553 0.109253525319702 no 412 0.121088139608213 644 2831986
SGTC_2158 5657123 3.6195 µM 1.16757688940296 0.10962053409943 no 413 0.12148873839383 644 2858827
SGTC_2302 7771753 200 µM 1.16608172763296 0.109897198894138 no 414 0.121790701809595 663 2203047
SGTC_2771 fluoxetine 41.05 µM 1.16567388619749 0.109972752801247 no 415 0.121873161073396 620 3386 A selective serotonin reuptake inhibitor.
SGTC_3339 9145883 14.936 µM 1.16500688210137 0.110096397715642 no 416 0.122008103545489 611 2030670
SGTC_1022 4477-0945 21.3 µM 1.16425948321337 0.110235064146009 no 417 0.12215943542147 653 4648966
SGTC_1248 0469-0687 58.6 µM 1.16003614008426 0.111020983571757 no 418 0.123017046118431 663 4017482
SGTC_2038 4100038 30.985 µM 1.15782595622635 0.111433871347851 no 419 0.123467534341196 673 3596803
SGTC_1171 0368-0077 21.4 µM 1.15746764414104 0.111500911557859 no 420 0.12354067561035 625 3239779
SGTC_865 0488-0499 301 µM 1.15572088687785 0.111828143248178 no 421 0.123897670946527 713 9634651
SGTC_330 1488-0319 80.1 µM 1.15189618917176 0.112547046458713 no 422 0.124681867197817 667 6846614
SGTC_1352 1496-0991 99 µM 1.15179977913679 0.11256521057369 no 423 0.124701679337617 660 3000039
SGTC_1924 st058459 75.1 µM 1.15146317880562 0.112628644114024 no 424 0.12477086752893 636 688683
SGTC_2205 7238770 200 µM 1.15063532716991 0.112784764321733 no 425 0.124941146523961 639 279867
SGTC_504 lovastatin 124 µM 1.14686297383312 0.113498128844076 no 426 0.125719128738854 585 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_570 0987-0065 62.6 µM 1.1467327328038 0.113522815183248 no 427 0.125746048903324 562 3104428
SGTC_1901 st060216 58.6 µM 1.14562309388886 0.113733295291581 no 428 0.12597556875327 675 688792
SGTC_3242 9133940 49.47 µM 1.14367533645729 0.114103424950825 no 429 0.126379152718205 670 17248444
SGTC_514 4466-0038 2.65 nM 1.14203830176743 0.114415171360192 no 430 0.126719049644859 731 5722064
SGTC_3195 9113082 49.47 µM 1.1374245257229 0.115297050689753 no 431 0.127680429674956 650 17018038
SGTC_1907 st060210 83.7 µM 1.13692740704074 0.115392357741256 no 432 0.12778431687289 745 688793
SGTC_185 k048-0037 25.491 µM 1.13692446103622 0.115392922712864 no 433 0.127784932700031 701 6827589
SGTC_3060 1327-0027 12.5 µM 1.13590260387429 0.115589008536043 no 434 0.127998664213806 645 16000455 YPR107C YTH1
SGTC_1088 bifonazole 369 nM 1.13478616177904 0.115803514886263 no 435 0.128232462859208 678 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2024 5144227 134 µM 1.13341541982331 0.116067267276135 no 436 0.128519920821981 722 3475211
SGTC_4 0960-0234 25.671 µM 1.12901290366675 0.116917264053547 no 437 0.129446195170061 629 6821112
SGTC_1774 st048371 48.465 µM 1.1277412145887 0.117163609127574 no 438 0.129714613144029 694 4242727
SGTC_395 anisomycin 6.25 µM 1.12691894661264 0.117323090274158 no 439 0.129888375964043 607 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3231 9132313 49.47 µM 1.12649995116518 0.117404414704811 no 440 0.129976980622281 688 4905967
SGTC_2178 5812956 200 µM 1.12490980518566 0.117713415423684 no 441 0.130313628281091 659 5403383
SGTC_1760 st045453 10.4495 µM 1.12342343365634 0.118002770519962 no 442 0.130628850992933 713 3323419 YIL048W NEO1
SGTC_1044 1222-0021 1.78 µM 1.11793490617815 0.119075591698327 no 443 0.131797397748723 692 4306703
SGTC_133 0724-0033 378.92 µM 1.11647176855831 0.119362744478646 no 444 0.132110124028955 656 280309
SGTC_1508 1080-0625 72.9 µM 1.11559045412481 0.119535945308975 no 445 0.132298740032588 652 767111
SGTC_3343 9148379 18.9835 µM 1.11538096132004 0.119577142071352 no 446 0.132343602282377 697 1955036
SGTC_517 1365-0151 113 µM 1.11028593605381 0.120582163882951 no 447 0.133437915762747 689 768657
SGTC_2523 spermine 47.74 µM 1.11025843528881 0.120587604649916 no 448 0.133443839236897 681 1103 A DNA binding polyamine.
SGTC_551 k048-0028 34.9 µM 1.10954606340784 0.120728600941788 no 449 0.133597342227552 752 6836383
SGTC_2843 9000894 45.46 µM 1.10869462746462 0.120897273696084 no 450 0.133780970190922 554 2242070
SGTC_1096 rimcazole 32.2 µM 1.10009655040685 0.12260988250731 no 451 0.135645028346998 674 18528119 A dopamine reuptake inhibitor.
SGTC_2707 st078556 66.6 µM 1.09861193888215 0.122907309659517 no 452 0.135968683959407 706 17250899
SGTC_1019 4262-0212 3.4 µM 1.09623411546027 0.123384736270748 no 453 0.136488166750591 774 4677213
SGTC_2717 st081029 62.2815 µM 1.09620835038907 0.123389916565356 no 454 0.136493803066904 701 5292846
SGTC_2709 st078560 56 µM 1.09406684492756 0.123821017850696 no 455 0.136962831163147 726 17250903
SGTC_556 4058-0063 51.5 µM 1.09336396425484 0.123962742607319 no 456 0.137117014426247 759 6615692
SGTC_1800 st050079 29.0735 µM 1.09238952619295 0.124159410340399 no 457 0.137330962350848 835 3645560
SGTC_2886 9058944 51.95 µM 1.09056113386985 0.124529017751541 no 458 0.13773301966186 549 4949929
SGTC_1237 0330-0133 46.1 µM 1.08854129036372 0.124938220276266 no 459 0.138178109387223 679 X1237 YHR072W ERG7
SGTC_1228 0124-0032 52.5 µM 1.08845772812421 0.124955169462243 no 460 0.138196544139862 723 X1228
SGTC_1293 1000-1278 195 µM 1.0877933074382 0.125089993115191 no 461 0.138343182351972 738 678847
SGTC_2249 haloperidol 116.36 µM 1.08704374894313 0.12524221477867 no 462 0.13850873782172 830 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1397 3532-0190 20.1 µM 1.08685117435371 0.125281344040725 no 463 0.138551293684495 643 5322280
SGTC_512 prima-1 270 µM 1.0844952964469 0.125760726224039 no 464 0.139072625667493 741 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1054 3429-0080 167 µM 1.08432578642776 0.125795267987726 no 465 0.139110187948826 736 1162877
SGTC_749 1000-0129 128 µM 1.08251126036768 0.126165436122757 no 466 0.139512707323241 766 708470
SGTC_898 1000-0849 28.3 µM 1.0823225017876 0.126203986929644 no 467 0.139554625399966 747 6751807
SGTC_212 3807-4682 38.772 µM 1.07864929536185 0.126955813169717 no 468 0.140372048570634 873 3125501 YBL034C STU1
SGTC_3148 9097893 49.47 µM 1.0774695404591 0.127197943674893 no 469 0.140635275736602 675 17174100
SGTC_990 3985-0011 41.3 µM 1.07338526571393 0.128038672628745 no 470 0.141549146327989 666 5399565 YGL099W LSG1
SGTC_687 k029-0044 34.9 µM 1.07292401062218 0.128133861876764 no 471 0.141652606038217 780 5829338
SGTC_3064 1327-0027 10 µM 1.07273242210261 0.128173414458445 no 472 0.141695594477305 569 16000455 YPR107C YTH1
SGTC_2199 6590217 200 µM 1.07178802082182 0.128368505734884 no 473 0.141907627417843 658 703109
SGTC_2533 agelasine 13.65 µM 1.0710189143891 0.128527537422146 no 474 0.14208046254869 759 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1199 1638-0010 4.46 µM 1.07083292829738 0.12856601514798 no 475 0.142122279098838 745 3111136
SGTC_3186 9110464 49.47 µM 1.07079043520614 0.128574807451428 no 476 0.142131834285774 725 17018021
SGTC_2636 apigenin dimethyl ether 100 µM 1.06934851762674 0.128873403931495 no 477 0.142456328042487 738 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1727 st034309 9.9045 µM 1.06841532438538 0.129066908483763 no 478 0.142666603734564 812 870305
SGTC_1144 3486-0183 12.5 µM 1.06504669623427 0.129767094300159 no 479 0.143427399443845 772 6744069
SGTC_1934 st074720 32.6 µM 1.06425092365904 0.1299328828887 no 480 0.143607521797333 776 17250992
SGTC_283 0987-0079 11.7 µM 1.06211720508845 0.130378138132579 no 481 0.144091240167965 780 411556
SGTC_1278 0874-0585 172 µM 1.06074618150625 0.130664793796795 no 482 0.144402633154595 746 766306
SGTC_237 nikkomycin 200 µM 1.05788249471011 0.131264942480054 no 483 0.145054508423512 765 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1001 4048-4355 44.4 µM 1.05736619924098 0.131373345793509 no 484 0.14517224574508 735 21824233
SGTC_1370 2001-0092 44.6 µM 1.0556034554393 0.131743923738035 no 485 0.145574710786291 852 790957
SGTC_1498 4478-3555 97.6 µM 1.05399755848139 0.132082155395488 no 486 0.145942017472339 720 3437919
SGTC_685 1278-0033 54.9 µM 1.05319744365057 0.132250897702718 no 487 0.146125254927058 765 3590572
SGTC_2561 acetosyringone 100 µM 1.05293436520042 0.132306412769675 no 488 0.14618553730642 860 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2829 7992743 58.44 µM 1.05278059448554 0.132338869050642 no 489 0.14622078040267 751 16462845
SGTC_3205 9113483 49.47 µM 1.04832387042946 0.13328193168696 no 490 0.14724470771044 770 17018033
SGTC_292 k038-0015 474 µM 1.04591706145761 0.133793141444377 no 491 0.14779966320804 725 46368540
SGTC_2720 fluspirilene 36.88 µM 1.04419085853568 0.13416061844408 no 492 0.148198547755812 681 3396 An atypical antipsychotic.
SGTC_1169 aniline yellow 25.8 µM 1.04379000338544 0.134246052267988 no 493 0.148291278827157 731 6051 A DNA damaging agent.
SGTC_2085 5307070 144.047 µM 1.04288416565226 0.13443925008433 no 494 0.148500972029527 709 2840351
SGTC_430 0958-0115 16.4 µM 1.04103872426719 0.134833437710941 no 495 0.14892878812233 727 6833180
SGTC_2415 st077333 57.7 µM 1.03951682528297 0.135159112497059 no 496 0.149282218571277 852 2766255
SGTC_1112 tnp00069 1.16933 µM 1.03825151608566 0.135430289329842 no 497 0.149576487216119 811 145826
SGTC_390 dec-rvkr-cmk 16.7 µM 1.03630326019758 0.135848561639746 no 498 0.150030342833372 794 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_431 k089-0097 107 µM 1.03319007621243 0.136518767635918 no 499 0.150757478035247 817 5499420
SGTC_2481 5478948 45.16 µM 1.03302417675997 0.136554545811715 no 500 0.150796292314319 735 77792
SGTC_828 2074-0507 139 µM 1.03023574377504 0.137156864070108 no 501 0.151449677197346 791 X828
SGTC_2923 7992654 58.14 µM 1.02980046223364 0.137251051010209 no 502 0.151551841861325 745 2985126
SGTC_439 amiodarone 34.4 µM 1.024352205226 0.138433691070498 no 503 0.152834474069999 782 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2207 7258803 200 µM 1.02192131580384 0.138963592472529 no 504 0.153409071428645 731 3666799
SGTC_2351 9026858 72.31 µM 1.02032999050716 0.139311227087841 no 505 0.153785992248879 722 1409300
SGTC_634 1611-4317 11.2 µM 1.02015931776228 0.139348546682215 no 506 0.153826454110417 846 2843522
SGTC_924 2046-0044 21.3 µM 1.01995347012809 0.139393566726136 no 507 0.153875264353921 795 3623589
SGTC_701 4424-0219 185 µM 1.01988908744014 0.139407649615899 no 508 0.153890532772281 858 2911779
SGTC_1831 st055328 12 µM 1.01628785923005 0.140196913643753 no 509 0.15474616415222 818 1103068
SGTC_3272 9137413 49.47 µM 1.01229778791264 0.141074936784135 no 510 0.155697846112538 754 17614870
SGTC_2032 5185112 25.99 µM 1.01211799658298 0.14111458783278 no 511 0.155740819282089 730 5718189
SGTC_41 0478-0632 82.643 µM 1.00937508618876 0.141720444410828 no 512 0.156397391053079 873 3750424
SGTC_3304 9125678 46.087 µM 1.00834915567656 0.141947504958738 no 513 0.156643436281545 778 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1500 4488-1866 171 µM 1.00789349849536 0.142048430665802 no 514 0.156752796576887 844 2900003
SGTC_1618 st003135 44.5 µM 1.00695770504256 0.142255856357757 no 515 0.156977549814316 777 1270615
SGTC_2360 9040895 200 µM 1.00673033175299 0.142306286299206 no 516 0.15703219095779 737 4914414
SGTC_1828 st055811 49 µM 1.00425652148955 0.142855743283862 no 517 0.157627492345877 776 5877589
SGTC_604 1000-0114 314 µM 1.00118326596352 0.143540337541966 no 518 0.15836910760275 863 1572745
SGTC_643 k048-0106 28.4 µM 1.00061439815221 0.143667300262751 no 519 0.158506633235591 805 6763920
SGTC_1787 fluconazole 80 µM 0.99832148278026 0.144179812596629 no 520 0.159061746825661 823 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1059 3448-6867 171 µM 0.996005502679292 0.144698730219606 no 521 0.159623735780611 834 3934407
SGTC_594 1487-1584 10.8 µM 0.993595010751718 0.145240158541813 no 522 0.160210037076285 806 5013332
SGTC_426 0988-0037 14.6 µM 0.988964309571758 0.146284095427917 no 523 0.161340302019589 860 5383008
SGTC_670 4204-0025 119 µM 0.985973770059795 0.146960948556829 no 524 0.162072992240265 851 719039
SGTC_886 0866-0150 153 µM 0.985061891479205 0.147167752553871 no 525 0.162296835397191 869 271463
SGTC_948 3448-0295 75.3 µM 0.981582380831658 0.147958658984151 no 526 0.163152815543871 851 678569
SGTC_2959 9079155 11 µM 0.981169494692316 0.148052698113143 no 527 0.163254582348242 755 16189457
SGTC_2847 9005661 71.43 µM 0.979614787666305 0.148407157701915 no 528 0.163638151333051 737 2991449
SGTC_3296 9122258 64.045 µM 0.978466502370555 0.148669320810744 no 529 0.163921825486852 804 4730474
SGTC_2756 carbadox 75.1 µM 0.97722194347357 0.148953813384952 no 530 0.164229643348057 802 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_211 3455-0679 143.504 µM 0.975794456450385 0.149280568892794 no 531 0.164583166218875 849 748649
SGTC_3125 9127534 49.47 µM 0.974937773614467 0.14947689545937 no 532 0.164795563757262 719 1639235
SGTC_1801 st050089 28.441 µM 0.96973386198875 0.150673180997917 no 533 0.166089583576801 915 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_823 0417-1665 178 µM 0.964692166061422 0.151838240361151 no 534 0.167349510107423 852 3429856
SGTC_609 0986-0026 86.3 µM 0.964584316028906 0.151863228081017 no 535 0.167376529089883 839 2848610
SGTC_3048 9093155 49.47 µM 0.960891561118496 0.15272044890567 no 536 0.168303347172076 785 25236002
SGTC_2374 9071832 200 µM 0.960768103411429 0.152749163202769 no 537 0.168334389855062 835 17381698
SGTC_1758 st042942 75.2445 µM 0.958167223309321 0.153354918820685 no 538 0.168989221068772 845 669317
SGTC_2757 clomiphene 4.22 µM 0.956962493704828 0.153636043849487 no 539 0.169293093098756 923 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1646 st011709 75.6 µM 0.952662632302034 0.154642202153995 no 540 0.170380516095393 813 5757843
SGTC_2148 5546263 113.568 µM 0.952302603267372 0.154726645289928 no 541 0.170471768977595 853 792097
SGTC_3270 9137563 49.47 µM 0.951513242902817 0.154911892698785 no 542 0.170671949599742 808 17015724
SGTC_2065 5221596 34.26 µM 0.94962843980034 0.155354811302782 no 543 0.171150541202464 814 788581
SGTC_2932 9016711 44.54 µM 0.948732258980591 0.155565701841869 no 544 0.171378401337072 904 7117328
SGTC_2806 7952793 58.44 µM 0.947968488330248 0.155745582416225 no 545 0.171572748254639 856 2972490
SGTC_2594 a-mangostin 100 µM 0.947815979184922 0.155781517254587 no 546 0.171611572160482 852 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1779 st039427 55 µM 0.947110274257669 0.155947869553494 no 547 0.171791294926805 935 1124498
SGTC_1106 tegaserod maleate 11.7 µM 0.945749256974997 0.156269025918308 no 548 0.172138246256271 880 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_229 benomyl 22.8748 µM 0.944886586711219 0.156472813830842 no 549 0.172358390066031 850 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1117 retinoic acid 1.10837 µM 0.944443688728609 0.156577507224815 no 550 0.172471482423844 915 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2780 5215298 71.43 µM 0.944253278841241 0.156622530988267 no 551 0.172520117426342 905 2834131
SGTC_2667 digitoxin 100 µM 0.944006691433464 0.156680850987432 no 552 0.172583114437175 828 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2254 7938975 95.19 µM 0.943572524622314 0.156783569830928 no 553 0.172694069010871 930 2969277
SGTC_814 3342-0569 96 µM 0.942788039324349 0.156969282329467 no 554 0.172894665379571 870 4346283
SGTC_2657 nystatin 74.44 µM 0.942147282967475 0.15712107696657 no 555 0.173058619740965 888 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1191 1487-1166 10.6 µM 0.940168555293523 0.157590445043779 no 556 0.173565554169027 952 3955771
SGTC_2479 5617353 43.85 µM 0.939507955739279 0.157747348804541 no 557 0.173735004750502 852 2731746
SGTC_746 1095-0025 46.6 µM 0.935252741541066 0.158760493870289 no 558 0.174829031896668 902 6749286
SGTC_791 1348-1292 225 µM 0.931336958916901 0.159696582482419 no 559 0.175839644777112 940 5437054
SGTC_327 1273-0057 3.96 µM 0.930682952037553 0.159853277554774 no 560 0.176008795398042 846 3108138
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.929330375731597 0.160177663524069 no 561 0.176358948917957 887 5282309
SGTC_2785 7756463 72.73 µM 0.92759047842314 0.160595572360048 no 562 0.17681001932451 884 2201551
SGTC_3149 9097855 49.47 µM 0.927141921663892 0.160703427323276 no 563 0.176926426323018 859 25236625 YMR079W SEC14
SGTC_3308 9128332 17.569 µM 0.92586901430174 0.161009753974536 no 564 0.177257027944737 944 17332805 YDL196W YDL196W
SGTC_3345 9148410 3.559 µM 0.92576561451365 0.161034653979317 no 565 0.177283900231658 880 4903596
SGTC_2839 9003951 25.97 µM 0.922619967918541 0.161793367385221 no 566 0.178102643030513 861 2990634
SGTC_2524 avocatin b 10.57 µM 0.920710464594062 0.162255063866909 no 567 0.178600805618768 845 6710748
SGTC_2551 apiole 73.87 µM 0.920369582009628 0.162337575593233 no 568 0.178689829315493 758 10659 A possible DNA adduct former.
SGTC_632 0781-2353 4.65 µM 0.919834453735773 0.162467160196891 no 569 0.178829637879328 903 6811515 YHR007C ERG11
SGTC_2107 5363541 170.161 µM 0.918973209713047 0.16267585704507 no 570 0.179054792561246 924 244052
SGTC_1156 4092-0367 4.88 µM 0.915635929792711 0.163486193784114 no 571 0.179928939877427 897 1357585
SGTC_1467 k284-1082 293 µM 0.915436780322346 0.16353463271649 no 572 0.179981188509389 918 3334705
SGTC_1479 0549-0158 134 µM 0.914809376639303 0.163687296430066 no 573 0.180145855715718 930 5440202
SGTC_2866 9034245 58.44 µM 0.913834096881969 0.163924791113769 no 574 0.180402013526156 896 6462273
SGTC_3071 9117417 49.47 µM 0.911381932958091 0.164522915711778 no 575 0.181047084842347 812 45595590 YGL055W OLE1
SGTC_3261 9137475 49.47 µM 0.911285497709275 0.164546466783988 no 576 0.181072482797952 714 17027690
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.908750219335974 0.165166407110945 no 577 0.1817409944933 825 521171
SGTC_1753 st043925 64 µM 0.908255221969025 0.165287622786879 no 578 0.181871697197632 929 670181
SGTC_1820 st053765 18.6 µM 0.908123518745511 0.165319884157751 no 579 0.181906482974241 868 3690829
SGTC_3187 9109394 49.47 µM 0.907430105815222 0.165489806357079 no 580 0.182089697506482 884 17098090
SGTC_1029 k015-0030 64.7 µM 0.90438033493603 0.166238499301841 no 581 0.182896880990779 875 2208316
SGTC_1942 st076330 65.2 µM 0.903201561299075 0.166528463546622 no 582 0.183209464700229 923 24208414
SGTC_1520 flindersine 88 µM 0.902946896053487 0.166591151018073 no 583 0.183277039819379 940 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1511 0906-3109 28.5 µM 0.90224000955002 0.166765235432978 no 584 0.183464692744352 998 2882180
SGTC_2167 5876490 200 µM 0.902175706133634 0.166781077209696 no 585 0.183481768927925 921 686534
SGTC_2318 6029776 164 µM 0.898512969589188 0.167685030782339 no 586 0.184456066949999 906 818325
SGTC_1098 clofazimine 15.1 µM 0.897336712851301 0.167975995901173 no 587 0.184769635928989 940 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2645 abamectin 100 µM 0.896943855069677 0.168073247637487 no 588 0.184874438550768 889 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3225 9130819 49.47 µM 0.896694176726006 0.168135074206987 no 589 0.184941064408523 928 4547121
SGTC_1622 st003707 19.4 µM 0.896319802949017 0.168227805885467 no 590 0.18504099279321 940 10140899
SGTC_803 4488-1585 147 µM 0.895224990929022 0.168499177512695 no 591 0.185333414019813 916 747204
SGTC_1005 4092-0690 4.4 µM 0.893526767001497 0.168920673730298 no 592 0.185787572209013 864 1529343
SGTC_2588 indole-3-carbinol 100 µM 0.892118676138424 0.169270672608884 no 593 0.186164662746849 946 3712 Induces cell cycle arrest.
SGTC_2341 7987486 176.74 µM 0.89076266305261 0.169608166596027 no 594 0.186528254738217 955 1258686
SGTC_987 1497-1013 404 µM 0.890519805856336 0.169668656135243 no 595 0.18659341919396 926 1676435
SGTC_1963 st076565 50.3 µM 0.89029266512791 0.169725243624677 no 596 0.186654379297426 912 4914280
SGTC_29 0299-0004 12.984 µM 0.889616819745702 0.169893688326053 no 597 0.186835835817536 834 16871 A napthoquinone isolated from Swertia calycina.
SGTC_774 k060-0086 136 µM 0.886768041474724 0.170604882734728 no 598 0.18760189850439 993 5911235
SGTC_2666 tannic acid 100 µM 0.886615043498579 0.170643132368851 no 599 0.18764309590714 956 16134267 A thiamine antagonist.
SGTC_2276 7947513 42.08 µM 0.88021094032729 0.172249086665179 no 600 0.189372523944964 876 2105100
SGTC_376 3970-0862 59.1 µM 0.879662856351373 0.172386976025844 no 601 0.189520988390767 948 3135186
SGTC_97 0535-0701 19.132 µM 0.877482547700911 0.17293620454806 no 602 0.19011229705394 862 2832013 YGL099W LSG1
SGTC_1611 st001856 99.4 µM 0.876541669106003 0.173173559659933 no 603 0.190367816994872 895 647478
SGTC_3303 9125618 40.5795 µM 0.874963228422196 0.173572218078928 no 604 0.190796956904988 981 22695467
SGTC_1556 plumbagin 1.48 µM 0.872473809792985 0.174202143181647 no 605 0.191474974921311 893 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_941 3237-0776 460 µM 0.871649685374114 0.174411000191457 no 606 0.191699758288633 915 760008
SGTC_592 k241-0073 46.5 µM 0.870928149233154 0.174593988903071 no 607 0.191896692897952 989 4230158
SGTC_1966 st070145 16.1 µM 0.869053905709291 0.17506988502076 no 608 0.192408823482429 937 3748532
SGTC_2004 4023728 41.89 µM 0.868286040510561 0.175265093925076 no 609 0.192618881106818 962 360084 YDR527W RBA50
SGTC_1273 0849-0096 14.1 µM 0.867595450217604 0.17544077562368 no 610 0.192807919025345 929 5286025
SGTC_1299 1079-1439 3.74 µM 0.866167795710003 0.175804315466598 no 611 0.193199075528508 927 323161
SGTC_503 tyrphostin 8 294 µM 0.862126010369344 0.176836106452932 no 612 0.194309089797024 944 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2112 5488546 200 µM 0.8601674115353 0.177337473489673 no 613 0.194848382899551 932 600757
SGTC_1435 4092-0789 56.7 µM 0.851986644022801 0.179441297347966 no 614 0.197110752494379 982 2248285
SGTC_1738 st035555 74 µM 0.851902784745696 0.179462944115137 no 615 0.197134025559535 973 5331140
SGTC_2685 mycophenolic acid 18.85 µM 0.851899210905195 0.179463866674383 no 616 0.197135017427381 967 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1074 carmofur 3.8 µM 0.851585076809742 0.179544969605808 no 617 0.197222212609301 1044 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2350 9023895 38.85 µM 0.850736617778498 0.179764139306338 no 618 0.197457838623931 960 2997209
SGTC_476 mead acid 10 µM 0.850525543987538 0.179818688930554 no 619 0.197516482469865 944 5312531 An omega 9 fatty acid.
SGTC_1250 0485-0349 40.2 µM 0.849208732047638 0.180159238762363 no 620 0.197882577618231 943 6842794 YDL195W SEC31
SGTC_2007 4011539 71.82 µM 0.848469107794401 0.180350695535666 no 621 0.198088384856835 950 45595301
SGTC_1107 amlodipine 47 µM 0.847912641627093 0.180494824716101 no 622 0.198243311844184 923 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2163 5671233 125 µM 0.846229429419953 0.180931229756687 no 623 0.19871238373344 1018 701023
SGTC_471 1-acyl-paf 4 µM 0.84434834443924 0.181419718819177 no 624 0.199237389255254 944 16759367
SGTC_3294 9122953 26.2835 µM 0.843390641427864 0.181668736565032 no 625 0.199505002097123 1037 16459826
SGTC_1920 st075728 45.7 µM 0.842813920004957 0.181818796270287 no 626 0.199666260825268 967 3400306
SGTC_1851 st056236 18.9 µM 0.841126861582368 0.182258204451294 no 627 0.200138434123651 1027 5393171
SGTC_3208 9114115 49.47 µM 0.840824504026427 0.182337026023682 no 628 0.200223128710783 895 650895
SGTC_1521 st012942 49.4 µM 0.840672176693726 0.182376744293696 no 629 0.200265805888198 1020 24207259
SGTC_2863 9028737 58.44 µM 0.840475267416108 0.182428094998579 no 630 0.200320981579327 988 6460917
SGTC_900 1112-0045 141 µM 0.837724334294696 0.183146437466745 no 631 0.201092771651319 889 56211 YIL048W NEO1
SGTC_1247 0448-0043 5.84 µM 0.837313975700668 0.183253744137178 no 632 0.201208052774444 995 3089013 YGL099W LSG1
SGTC_270 tamoxifen 5.46 µM 0.836220681567041 0.183539826286799 no 633 0.201515382817643 1053 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2057 5236571 38.335 µM 0.831296930045977 0.184831670414961 no 634 0.202902954224832 1013 54684039 YBR257W POP4
SGTC_111 0083-0039 52.457 µM 0.830632451566907 0.185006441344802 no 635 0.203090648190337 925 759313
SGTC_2021 4019055 173 µM 0.829864311358115 0.185208605257126 no 636 0.203307752418363 1058 44827708 YER133W GLC7
SGTC_1821 st053465 65.6 µM 0.827908341428188 0.185724008728374 no 637 0.203861205301439 968 675086
SGTC_727 3032-0951 202 µM 0.827447815872894 0.185845487767883 no 638 0.203991644122394 960 3652836
SGTC_219 mitoxanthrone 164.414 µM 0.826948805347849 0.185977174121588 no 639 0.204133039509339 947 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2342 7990637 118.86 µM 0.825589697431875 0.186336129097441 no 640 0.204518440691697 1019 2033102 YER133W GLC7
SGTC_2985 9022375 71.43 µM 0.824170416578714 0.186711434212257 no 641 0.204921366911037 1033 4939335
SGTC_2361 9034121 116 µM 0.822470856203293 0.187161469764542 no 642 0.205404483440691 980 6496917
SGTC_2403 6032726 181.2 µM 0.819145622901157 0.18804391406885 no 643 0.20635166741986 983 2881040
SGTC_2610 ononetin 44.17 µM 0.818346816545582 0.188256281805407 no 644 0.206579590300695 996 259632
SGTC_1600 coumarin 106 71.1 µM 0.817001809021209 0.188614194774647 no 645 0.206963697119268 1031 100336 A hepatotoxic, DNA x-linker.
SGTC_1635 st007035 42.4 µM 0.816889732480649 0.188644037804313 no 646 0.20699572296661 1066 3716403
SGTC_1209 2323-2347 50.3 µM 0.81590219516529 0.18890711877807 no 647 0.207278038272449 1038 5412760
SGTC_357 1325-0123 420 µM 0.812170491544483 0.189903287992114 no 648 0.208346904569273 1020 1098503
SGTC_2441 5730946 39.09 µM 0.811497511007529 0.190083281640298 no 649 0.208540010836919 1009 1774275
SGTC_2295 7971645 200 µM 0.808958076642163 0.19076341597852 no 650 0.209269630566445 995 2978226 YKL099C UTP11
SGTC_1451 4152-0210 104 µM 0.807008607791838 0.191286552316004 no 651 0.209830761965593 1049 659563
SGTC_2753 fluvastatin 17.09 µM 0.806966147163203 0.191297956322943 no 652 0.209842993585746 1011 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2820 7989630 71.43 µM 0.805761250673699 0.191621739144573 no 653 0.210190262406492 930 2984098
SGTC_1360 1598-0022 39.8 µM 0.805226347060394 0.191765587313046 no 654 0.210344537588076 1064 761525
SGTC_2592 piperlongumine 83.33 µM 0.803897893683682 0.192123125603793 no 655 0.210727973313948 1003 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2789 5281112 71.43 µM 0.803585738988226 0.192207197671395 no 656 0.210818130972132 1011 765948
SGTC_2460 5552655 174.22 µM 0.802571261557612 0.192480580450778 no 657 0.211111292229769 1039 5401989
SGTC_116 0155-0182 31.788 µM 0.800777704993509 0.192964491849188 no 658 0.211630174109488 1059 771486
SGTC_641 4092-0595 30 µM 0.800147436196783 0.193134718093711 no 659 0.211812690081533 1032 786260
SGTC_2586 curcumin 80 µM 0.798015343120459 0.193711244048144 no 660 0.212430793202427 1090 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3152 9099253 49.47 µM 0.796793562858934 0.194042090429191 no 661 0.212785467117466 1085 25236131
SGTC_1791 st048313 56.1 µM 0.796625801585578 0.1940875454398 no 662 0.212834193970952 1000 1204976
SGTC_1218 1348-1416 30.7 µM 0.795812263917838 0.194308065912271 no 663 0.213070581211844 1069 6787668
SGTC_2088 5278280 127.392 µM 0.795241813740754 0.19446278516397 no 664 0.213236426550719 1069 791502
SGTC_832 4083-0019 164 µM 0.795191489123574 0.194476437960072 no 665 0.213251060894351 1175 1990758
SGTC_2676 harmalol 100 µM 0.79210356153237 0.195315291876526 no 666 0.214150146798326 1061 5459187 A monoamine oxidase inhibitor
SGTC_179 1273-0063 6.77 µM 0.790788104911234 0.195673310206185 no 667 0.214533826199517 1039 3108139
SGTC_1094 duloxetine 25.4 µM 0.790693919284711 0.195698959302586 no 668 0.214561312655615 1047 60834 A selective serotonin reuptake inhibitor.
SGTC_2474 5321570 43.32 µM 0.790576845882781 0.19573084415636 no 669 0.214595481369185 1047 2841384
SGTC_2700 st077718 96.8 µM 0.789928262887166 0.195907542369364 no 670 0.214784832265282 1005 904970
SGTC_1072 oxiconazole 14.9 nM 0.789562209585758 0.196007311664072 no 671 0.214891742724104 1053 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_383 2324-0395 7.37 µM 0.789100026056134 0.196133325655052 no 672 0.215026773364573 1074 3146421
SGTC_2958 9077254 16.72 µM 0.789097502606587 0.196134013806501 no 673 0.21502751074589 1056 16457351
SGTC_458 nppb 133 µM 0.78812056368429 0.196400537670056 no 674 0.215313093968024 1037 4549 A chloride channel blocker.
SGTC_2095 5432005 200 µM 0.786856199750612 0.196745801172383 no 675 0.215683025123225 1033 783734
SGTC_335 4077-0256 27.6 µM 0.786440137141617 0.196859496923603 no 676 0.215804838423249 1113 3121989
SGTC_1643 st009866 20.2 µM 0.78605413356448 0.196965014130695 no 677 0.215917886797985 1078 3156273 YOR207C RET1
SGTC_2965 9082772 38.63 µM 0.781846227584626 0.198117498842892 no 678 0.217152474872607 1105 16459634
SGTC_2629 bisabolol 100 µM 0.779482577898697 0.19876665048239 no 679 0.217847748239278 1073 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_737 1950-0117 57.9 µM 0.778634571203456 0.198999858862427 no 680 0.218097504092809 1062 5393513
SGTC_528 3492-0019 172 µM 0.775842284640543 0.199768923697504 no 681 0.218921056878714 1138 2869262
SGTC_3199 9111318 49.47 µM 0.77567784727566 0.199814269494148 no 682 0.218969611499376 1020 8548020
SGTC_3278 9139605 49.47 µM 0.775653190196647 0.199821069546307 no 683 0.218976892709023 1071 7958859
SGTC_3058 9093861 49.47 µM 0.773681908907568 0.20036516962546 no 684 0.219559460470123 1054 17217477
SGTC_265 mycophenolic acid 32.932 µM 0.771699872253594 0.200913134686236 no 685 0.220146103203289 1148 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_49 0717-0965 32.132 µM 0.769937364043958 0.201401162156893 no 686 0.220668524286674 1183 5889349 YGL099W LSG1
SGTC_2345 9052315 157.45 µM 0.7685490545912 0.201786076107065 no 687 0.221080529474614 1050 6469265
SGTC_692 k241-0027 77.8 µM 0.7672654852862 0.20214234208504 no 688 0.221461842507629 1085 3600480
SGTC_280 3448-3607 3.04 µM 0.767134182452128 0.202178807551283 no 689 0.221500870144767 1077 626179
SGTC_1559 coumarin 343 70.1 µM 0.764814969163144 0.202823548698446 no 690 0.222190866390326 1063 108770 A hepatotoxic, DNA x-linker.
SGTC_769 0302-0231 76 µM 0.763306560357237 0.203243544713802 no 691 0.222640295262841 1120 571869 YER009W NTF2
SGTC_290 2043-6722 48.1 µM 0.762797964908287 0.203385273164399 no 692 0.222791947500478 1100 773758 YLR208W SEC13
SGTC_2997 9067075 71.4286 µM 0.762176328237964 0.203558582462664 no 693 0.222977386118375 1090 27209819
SGTC_2180 6301957 200 µM 0.760345693861887 0.204069465831639 no 694 0.223523987654582 1089 845462
SGTC_965 1291-5240 308 µM 0.75769876508771 0.204809505298316 no 695 0.224315669233672 1091 2834598
SGTC_2000 st075254 36.4 µM 0.757418971723029 0.204887824263624 no 696 0.22439944678547 1056 17234175
SGTC_1025 k007-0731 70 µM 0.755951567453947 0.205298867422825 no 697 0.224839117225086 1117 6256118
SGTC_153 4077-0274 519.67 µM 0.755146915578837 0.205524470952951 no 698 0.225080417921241 1093 3121976
SGTC_1614 st002383 48.6 µM 0.754864834624822 0.205603593973612 no 699 0.225165043674334 1153 1947235
SGTC_1121 fusaric acid 630.51 nM 0.754740517521191 0.205638470358289 no 700 0.225202345173399 1073 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2539 epi(13)torulosol 80 µM 0.754255028979091 0.205774704758478 no 701 0.225348050126073 1099 6708597
SGTC_3240 9133527 49.47 µM 0.75291207995806 0.206151832589974 no 702 0.225751374277384 1068 17617455
SGTC_385 1494-0393 12.4 µM 0.752530384560384 0.206259095282961 no 703 0.225866082274033 1088 3090647
SGTC_1880 MG-132 525 µM 0.752169274872194 0.206360603498319 no 704 0.225974634140302 1057 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_50 0929-0078 56.389 µM 0.749713498274277 0.207051709069146 no 705 0.22671363803972 1018 1377751
SGTC_2139 5578692 56.4705 µM 0.749616506115945 0.207079032719482 no 706 0.226742853346951 1079 650991 YMR113W FOL3
SGTC_1409 3909-8004 61.9 µM 0.748656793519441 0.20734950821164 no 707 0.22703204581646 1124 2119279
SGTC_3010 9080089 71.4286 µM 0.743818414009816 0.208716284724284 no 708 0.228493169237838 1123 17027233
SGTC_353 1988-1175 58.3 µM 0.742513249043976 0.20908588345025 no 709 0.228888213743382 1027 2788357
SGTC_2972 9093619 59.92 µM 0.741677312415107 0.209322807675619 no 710 0.229141434473215 1121 25236256
SGTC_1036 k216-0215 33.5 µM 0.741247054287929 0.209444814578225 no 711 0.229271828873112 1131 622330
SGTC_1127 asiatic acid 681.4 nM 0.741219742272765 0.209452560769877 no 712 0.229280107480072 1082 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2662 daunorubicin 22.37 µM 0.740722339093049 0.209593662978571 no 713 0.229430905804547 1097 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1347 1493-0251 600 nM 0.740185773146423 0.209745937459599 no 714 0.229593639457176 1133 3986378
SGTC_3313 9133968 57.047 µM 0.736847343769112 0.21069482579587 no 715 0.230607594281479 1132 1494643
SGTC_1805 st050013 60.3 µM 0.736163021183881 0.210889642704331 no 716 0.230815746771926 1080 4037144
SGTC_1402 3909-7673 35.9 µM 0.735713256863979 0.211017741715531 no 717 0.230952610083593 1142 5328014
SGTC_1977 st070720 65.3 µM 0.731727252837092 0.212155001874053 no 718 0.232167529422715 1105 682188
SGTC_1868 st057644 42.7 µM 0.730816346448001 0.212415397745237 no 719 0.232445668805231 1168 688665
SGTC_3113 9123498 49.47 µM 0.730773576112177 0.212427628857404 no 720 0.232458733004425 1190 8897275
SGTC_1306 1185-0270 9.02 µM 0.729036840875911 0.212924633746614 no 721 0.232989563594078 1151 1548076
SGTC_893 0958-0369 48.9 µM 0.728970621146213 0.212943597395545 no 722 0.233009816872889 1153 6819948
SGTC_1152 3909-8331 15.9 µM 0.727998073795741 0.213222223771417 no 723 0.233307382706449 1131 16001939
SGTC_2089 5281248 129.67 µM 0.725736148699573 0.213871067317238 no 724 0.234000268378152 1154 2737878
SGTC_2186 6124449 200 µM 0.725673363470837 0.213889093930338 no 725 0.234019517349154 1115 3834182 YLR033W RSC58
SGTC_2066 5222451 176 µM 0.725397143137652 0.213968411579493 no 726 0.234104212607578 1185 2281147
SGTC_953 1188-0045 9.7 µM 0.723945546419776 0.214385524068453 no 727 0.234549583125572 1151 6144426
SGTC_205 1486-1330 71.903 µM 0.722113824458525 0.214912538790595 no 728 0.235112249688943 1121 4118834
SGTC_1649 st011737 51.3 µM 0.721253838938374 0.215160229267182 no 729 0.235376676161905 1119 1761035
SGTC_2937 9044753 11.33 µM 0.718146992690238 0.216056433436869 no 730 0.236333328795443 1192 6465530 YGL099W LSG1
SGTC_2106 5357045 167.29 µM 0.717166320353805 0.216339767565587 no 731 0.23663573897402 1159 668842
SGTC_336 4111-0029 111 µM 0.716878797898276 0.216422878803467 no 732 0.236724442687437 1123 3131175
SGTC_2784 7567673 72.73 µM 0.716756686659393 0.216458181866427 no 733 0.236762120826181 1206 3471247
SGTC_882 0843-0131 351 µM 0.716556789516192 0.216515980474795 no 734 0.236823807379837 1198 5425421
SGTC_1463 k081-0032 34.1 µM 0.716003021203324 0.216676144636068 no 735 0.236994741701796 1017 977755
SGTC_705 1124-0212 310 µM 0.714973241692834 0.216974165710318 no 736 0.237312788902907 1162 9554485
SGTC_2823 7987624 58.44 µM 0.714476080611807 0.217118130275441 no 737 0.237466420862818 1173 2239440
SGTC_180 1486-1293 102.781 µM 0.714113026127624 0.217223296010907 no 738 0.23757864588999 1180 4140536
SGTC_1086 cerivastatin 2.18 µM 0.714091513425527 0.217229528503353 no 739 0.237585296669031 1137 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1138 3761-0006 1.03 µM 0.713560693862317 0.217383346125836 no 740 0.237749435034792 1163 12061087
SGTC_1751 st044839 27.194 µM 0.71199972196174 0.217836039156166 no 741 0.238232474096699 1175 5291326
SGTC_1504 k297-0033 30 µM 0.711944348266055 0.217852107904318 no 742 0.238249619224692 1081 4388117
SGTC_3356 9151811 4.48 µM 0.709487626359813 0.218565705296659 no 743 0.239010963700043 1157 1859254 YPR165W RHO1
SGTC_1028 k015-0029 4.8 µM 0.707954661069533 0.219011662631276 no 744 0.239486706715622 1189 4588309
SGTC_1502 4534-4282 27.7 µM 0.70770324048123 0.219084853709254 no 745 0.239564782327572 1141 3278949
SGTC_3155 9099265 49.47 µM 0.707648718739774 0.219100727395546 no 746 0.239581715225769 1117 25236499
SGTC_650 1328-0195 38 µM 0.706591291983581 0.219408721778757 no 747 0.239910251001967 1162 2780821
SGTC_473 2-arachidonoylglycerol 10 µM 0.705091546089462 0.219845975817075 no 748 0.240376633605169 1124 5282280 An endocannabinoid.
SGTC_2312 7706453 155.7 µM 0.703570286050591 0.220290012872802 no 749 0.240850210663755 1194 976098
SGTC_946 3434-1334 87.4 µM 0.703358224950233 0.220351951703697 no 750 0.240916266799945 1141 4047976
SGTC_2138 5575593 77.673 µM 0.700974358017311 0.221048918405893 no 751 0.24165950888016 1181 762213
SGTC_3139 9095020 49.47 µM 0.700089001643688 0.22130808931758 no 752 0.241935861975483 1020 25236292
SGTC_1405 3909-7894 12 µM 0.700056607323217 0.221317575421294 no 753 0.24194597671395 1188 7104060
SGTC_3307 9126885 69.2785 µM 0.699904369413219 0.221362158714432 no 754 0.241993514249392 1186 24824909
SGTC_2769 toremifene 3.73 µM 0.699237682940177 0.221557460173142 no 755 0.242201752222459 1201 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_608 k048-0125 159 µM 0.698888929708753 0.221659664382438 no 756 0.242310723169949 1214 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_826 1683-5028 118 µM 0.697998762620855 0.221920655247366 no 757 0.242588983949819 1198 722377
SGTC_2620 irigenin 100 µM 0.69793023404328 0.221940754626982 no 758 0.24261041273447 1219 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2935 9038016 29.96 µM 0.697459025577535 0.222078987856035 no 759 0.242757786673887 1188 6463195
SGTC_8 0354-0001 70 µM 0.697114061497796 0.222180217314754 no 760 0.242865707460127 1227 4993152
SGTC_2815 7968870 71.43 µM 0.696939405257184 0.222231480101644 no 761 0.242920357942181 1204 2977326 YHR190W ERG9
SGTC_2748 diazoxide 86.69 µM 0.694073747981923 0.223073533126818 no 762 0.243817980449426 1140 3019 A potassium channel activatior.
SGTC_3042 9091578 49.47 µM 0.692804881045626 0.223446960222402 no 763 0.244216004326286 1167 25236497
SGTC_2275 7947463 200 µM 0.691696633188951 0.223773407938731 no 764 0.244563930886776 1165 1225414
SGTC_2531 methyl deoxycholate 70.07 µM 0.691541675384167 0.223819074215241 no 765 0.244612600057826 1182 16667744 Haematoxylin.
SGTC_1642 st009582 77.7 µM 0.689857895138669 0.224315627914897 no 766 0.245141778131851 1205 6739311
SGTC_2921 7974240 10.71 µM 0.689344919345637 0.224467030774668 no 767 0.245303118313857 1203 2979074 YDR527W RBA50
SGTC_533 1222-0222 6.71 µM 0.689053852739018 0.22455296376048 no 768 0.245394689411849 1254 3982874
SGTC_2329 6138490 200 µM 0.688258489207241 0.224787877900465 no 769 0.245645008654752 1166 720019
SGTC_3093 9117344 49.47 µM 0.686550093949274 0.225292930818437 no 770 0.246183143319927 1184 24824913
SGTC_2096 5468907 200 µM 0.684173985030973 0.225996447218862 no 771 0.2469326537998 1221 759785
SGTC_1276 0871-0068 94.2 µM 0.683836796066232 0.22609638238091 no 772 0.247039114220192 1181 3414906
SGTC_2229 7354935 190 µM 0.683096031330966 0.22631601593014 no 773 0.247273081520636 1172 318112
SGTC_2447 5741742 33.78 µM 0.682656863178684 0.226446284277252 no 774 0.247411846778886 1248 1776504
SGTC_2747 doxorubicin 7.63 µM 0.682238702926093 0.226570360493906 no 775 0.247544012779521 1109 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2856 9022925 19.48 µM 0.681903525959191 0.226669841671743 no 776 0.247649977860325 1211 4944862
SGTC_2358 9037157 4 µM 0.681480655462113 0.226795385622691 no 777 0.247783701514499 1224 2388925
SGTC_21 0849-0113 22.993 µM 0.681446282743138 0.226805592094618 no 778 0.247794572837811 1196 1560156
SGTC_519 k048-0011 62.8 µM 0.681270151658592 0.226857895688201 no 779 0.247850283161396 1208 6836379
SGTC_2336 9001819 198.65 µM 0.679936237057719 0.227254233569118 no 780 0.248272417786504 1270 2989602
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.679690317314843 0.227327344774847 no 781 0.24835028411768 1251 688788
SGTC_2827 7993847 71.43 µM 0.679598622141844 0.227354608867765 no 782 0.248379321176451 1172 2985692
SGTC_3188 9110789 49.47 µM 0.679552433791917 0.227368342932447 no 783 0.248393948300516 1243 849217
SGTC_2282 7944268 200 µM 0.678125213358261 0.227792955952659 no 784 0.248846152761953 1260 2970414
SGTC_1676 st018489 23.4 µM 0.67774914413071 0.227904914726844 no 785 0.248965380484193 1232 3696235
SGTC_2946 9065502 71.43 µM 0.676073729751409 0.228404074817997 no 786 0.249496917405169 1063 16489101
SGTC_1620 st003704 16.5 µM 0.675320192810433 0.228628777953068 no 787 0.249736178715878 1214 2834414
SGTC_356 1634-0012 32.5 µM 0.675267183142367 0.228644589997438 no 788 0.249753014809261 1231 735457
SGTC_1162 k048-0130 20.1 µM 0.673800197619597 0.229082414891195 no 789 0.250219174601754 1218 6797406
SGTC_1371 2421-0008 32.7 µM 0.672885205167668 0.229355734268337 no 790 0.250510162612737 1211 2827552
SGTC_2103 5378138 10 µM 0.672855733458221 0.22936454086421 no 791 0.250519538253654 1271 244142
SGTC_2231 micatex 6.853 µM 0.672405473364158 0.229499109007962 no 792 0.250662799648907 1250 20737 An antifungal of unknown mechanism.
SGTC_2015 5119600 184 µM 0.671329889726013 0.229820745084885 no 793 0.251005198764753 1237 2828786
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.668883393024904 0.230553269842799 no 794 0.25178493229724 1341 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_363 0455-0021 3.06 µM 0.668733106949248 0.230598310674429 no 795 0.251832872280386 1256 4597466
SGTC_217 ketoconazole 989 nM 0.661907052388995 0.232649259468095 no 796 0.254015395884787 1195 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1514 1189-1591 158 µM 0.661670629777795 0.232720475957094 no 797 0.254091165712294 1282 767698 YMR146C TIF34
SGTC_2469 5655019 90.81 µM 0.661161372821836 0.232873918220825 no 798 0.254254415033732 1299 2788239
SGTC_1708 st033234 31.827 µM 0.660807531310845 0.2329805659364 no 799 0.254367876167525 1315 674664
SGTC_890 0929-0006 47.2 µM 0.659652110205019 0.233328998311788 no 800 0.254738552727959 1241 1378169
SGTC_65 0798-0905 34.986 µM 0.65866798067759 0.233626003352602 no 801 0.255054499255674 1410 3602145
SGTC_2362 9071156 126 µM 0.65835240503292 0.233721286765868 no 802 0.255155855556696 1269 653133
SGTC_766 1391-0721 126 µM 0.656674333125962 0.234228317496018 no 803 0.255695170776751 1267 1020919 YIL115C NUP159
SGTC_1437 4092-1038 11.6 µM 0.656659968176095 0.234232660503834 no 804 0.255699790093461 1245 3977136
SGTC_2212 7123476 200 µM 0.656474486753568 0.234288741784305 no 805 0.255759439006903 1213 1085715
SGTC_2834 9001755 58.44 µM 0.656308149114717 0.234339041161949 no 806 0.255812937654586 1215 2989575
SGTC_3316 9136639 10.545 µM 0.655616422237415 0.234548278785476 no 807 0.256035478216795 1290 4903665
SGTC_1961 st076550 68.7 µM 0.655195483123658 0.234675657490366 no 808 0.256170951057347 1243 1579337
SGTC_982 1491-0518 27.5 µM 0.655078819675374 0.234710967319473 no 809 0.256208504024815 1234 3091256
SGTC_543 3844-1095 191 µM 0.654260528982513 0.234958717019311 no 810 0.256471985458033 1266 4230703
SGTC_3350 9150499 3.57 µM 0.653212581941052 0.23527620951319 no 811 0.256809619984984 1236 4910996 YPR165W RHO1
SGTC_2621 lithochol-11-enic acid 100 µM 0.653058703833379 0.235322849308329 no 812 0.256859216926191 1247 6708711
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.651744038081828 0.235721526867582 no 813 0.257283154147784 1263 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2248 tofa 1.1 µM 0.649799976316102 0.236311753267246 no 814 0.257910717126429 1242 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1373 2887-0003 58.5 µM 0.649097661948971 0.236525179164941 no 815 0.258137626497366 1257 776948
SGTC_610 4215-0184 155 µM 0.648383704464642 0.236742251964733 no 816 0.258368403671832 1303 5605015
SGTC_1853 st056710 91.2 µM 0.646807902490963 0.237221748932891 no 817 0.25887813860702 1373 269167
SGTC_2798 7813637 45.45 µM 0.646426312940154 0.237337942073349 no 818 0.259001652071949 1264 956368
SGTC_2516 gossypol 71.55 µM 0.641348815829516 0.238886999052072 no 819 0.260648039887783 1295 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_427 1354-0053 47.3 µM 0.637465303039953 0.240075513814612 no 820 0.261910901799284 1353 6813657
SGTC_2608 thymoquinone 42.66 µM 0.637081896290257 0.24019302665022 no 821 0.262035750059051 1219 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1730 st033808 45.1 µM 0.634729697502501 0.240914653044828 no 822 0.262802360722013 1314 1045166
SGTC_492 tmb-8 126 µM 0.633840548887681 0.241187740015432 no 823 0.263092443705114 1197 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3164 9100705 49.47 µM 0.633106921062044 0.241413188031681 no 824 0.263331911470715 1315 17174235
SGTC_3298 9116858 71.43 µM 0.633001196222173 0.241445687313061 no 825 0.263366430909717 1320 2506942
SGTC_3327 9140648 26.9345 µM 0.632716065147957 0.241533347009781 no 826 0.263459538473593 1275 8029710
SGTC_1560 lithocholic acid 53.1 µM 0.632371471297048 0.241639310795123 no 827 0.263572085611135 1245 9903 A bile acid which acts as a detergent.
SGTC_874 0599-0792 117 µM 0.631054157611207 0.242044621801266 no 828 0.264002556947246 1303 765305
SGTC_3004 9076122 71.4286 µM 0.630043736873003 0.242355757679752 no 829 0.264332984539329 1292 44782551
SGTC_2402 5553605 200 µM 0.629159394870831 0.242628248245019 no 830 0.264622354569216 1347 6758546
SGTC_1004 4084-0029 199 µM 0.628727874516826 0.242761271962238 no 831 0.264763613005487 1317 716894 YLR208W SEC13
SGTC_2740 felodipine 17.08 µM 0.628078140808558 0.24296163821601 no 832 0.264976376008747 1275 3333 L-type calcium channel blocker
SGTC_1087 pterostilbene 9.05 µM 0.627587504873786 0.243113000827538 no 833 0.26513709811246 1364 5281727 Similar to reservatol, lowers cholesterol.
SGTC_13 0199-0087 65 µM 0.627109762606315 0.24326043469029 no 834 0.265293644082415 1315 4589825
SGTC_2159 5658611 73.75 µM 0.627065665019788 0.243274045881352 no 835 0.265308096287733 1309 793844
SGTC_1444 4112-3581 28 µM 0.626928664239483 0.243316335261361 no 836 0.265352998423713 1317 2877249
SGTC_38 0929-0051 58.268 µM 0.626703811126392 0.243385751496763 no 837 0.265426702604591 1312 1379719
SGTC_1322 1348-1070 12 µM 0.626233573619006 0.243530956930617 no 838 0.265580874448813 1280 6758089
SGTC_1509 1326-1131 80 µM 0.626045223321517 0.243589131059095 no 839 0.265642639624556 1270 768313
SGTC_2384 9036245 200 µM 0.62594011503666 0.243621598208907 no 840 0.265677110651024 1335 6462766
SGTC_2912 7964298 10.93 µM 0.625421872501183 0.243781713547038 no 841 0.265847105214144 1315 2975850
SGTC_1597 7-benzyloxygramine 47.5 µM 0.623961990721568 0.244233061369825 no 842 0.266326273635757 1301 260807
SGTC_940 3232-1287 54.8 µM 0.623504629423076 0.244374555184811 no 843 0.26647648051014 1282 1585493 YIL048W NEO1
SGTC_3069 9117009 49.47 µM 0.622773861094117 0.244600724553293 no 844 0.266716568787913 1208 41904981
SGTC_1200 1643-0193 18.4 µM 0.622204521846838 0.244777010478714 no 845 0.266903696537202 1297 5403974
SGTC_2556 citropten 84.59 µM 0.621844557474726 0.244888502422352 no 846 0.26702204214931 1289 2775 A potential DNA crosslinker.
SGTC_1876 myriocin 605 nM 0.621619234414751 0.244958305750616 no 847 0.267096135173307 1384 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2861 9024595 19.48 µM 0.621039985338114 0.245137801726053 no 848 0.267286657385156 1261 16482810
SGTC_184 1494-0393 24.714 µM 0.620551496614812 0.245289228114604 no 849 0.267447380672083 1289 3090647
SGTC_827 3253-0474 693 µM 0.62011079873856 0.245425882974332 no 850 0.267592421554187 1321 5402065
SGTC_1678 st019265 80.2 µM 0.619132439128636 0.245729406134925 no 851 0.267914557377668 1349 5367020
SGTC_856 0433-0016 11.3 µM 0.618175381523785 0.246026515530747 no 852 0.268229868138758 1311 3911780
SGTC_738 1315-0003 72.4 µM 0.617438593794916 0.246255375474375 no 853 0.268472736250504 1338 6251474
SGTC_3019 9081971 49.47 µM 0.617411268283273 0.246263865480019 no 854 0.26848174571335 1373 16451803
SGTC_876 0720-0963 56.8 µM 0.617079371903536 0.246366997838354 no 855 0.268591187018809 1396 765861
SGTC_1257 0669-0121 16 µM 0.616788839598767 0.246457295862168 no 856 0.268687007110976 1343 4307855
SGTC_2390 9097792 176.6 µM 0.616064168969726 0.246682602212457 no 857 0.268926084638552 1274 4497149
SGTC_1116 jasmonic acid 1.58368 µM 0.614577388918121 0.247145200043173 no 858 0.269416925321452 1371 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3324 9138759 60.749 µM 0.613609719382458 0.247446530525152 no 859 0.269736629663012 1333 45595710
SGTC_1685 st024049 53.0905 µM 0.612342881868927 0.247841317933482 no 860 0.270155461870199 1297 1941139
SGTC_1424 4048-1941 275 µM 0.61083783578031 0.248310775471908 no 861 0.270653471206575 1390 X1424
SGTC_1111 tnp00062 510.699 nM 0.609925296663719 0.248595647527152 no 862 0.27095564718838 1396 676306
SGTC_540 1187-0821 17.3 µM 0.608254438066648 0.24911769898728 no 863 0.271509367143982 1318 847520
SGTC_1349 flufenamic acid 69 µM 0.60777192242251 0.24926856704933 no 864 0.271669376900297 1297 3371 A non-steroidal anti-inflammatory.
SGTC_2187 6125751 200 µM 0.60738117524435 0.249390777476208 no 865 0.271798989186336 1320 874498
SGTC_2035 5154463 94.595 µM 0.606591704530275 0.249637790165257 no 866 0.272060953403842 1344 2769623
SGTC_2426 5582046 32.21 µM 0.605416221648504 0.250005820516796 no 867 0.27245123765942 1364 2251934
SGTC_1991 st073000 8.92 µM 0.60520956930969 0.250070550761977 no 868 0.272519879170781 1395 4301969 YIL048W NEO1
SGTC_26 0302-0163 425.158 µM 0.605074762246753 0.250112781517531 no 869 0.272564661227463 1337 3100915
SGTC_320 4092-0846 5.34 µM 0.604618945715594 0.250255602323902 no 870 0.272716107660865 1353 1359356
SGTC_3248 9135562 49.47 µM 0.602388917643032 0.250954958962503 no 871 0.273457642607596 1367 17650701
SGTC_2211 7117706 200 µM 0.597657925611921 0.252442058038732 no 872 0.275034102453007 1326 822771
SGTC_435 c-PAF 6.7 µM 0.597527687066123 0.25248306167787 no 873 0.275077563741487 1310 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_894 0960-0238 55.9 µM 0.596140043626149 0.252920158066111 no 874 0.275540837571219 1332 6741907 YDL195W SEC31
SGTC_1061 3448-9325 110 µM 0.594223745911809 0.253524430348773 no 875 0.276181236272913 1306 723482
SGTC_1141 3253-0389 52.6 µM 0.591908768309043 0.254255430034327 no 876 0.276955840962308 1325 5402031
SGTC_1619 st003326 88.7 µM 0.591669769300044 0.254330961554795 no 877 0.277035871925636 1393 2849032
SGTC_2914 7968218 45.32 µM 0.590919574509368 0.254568124079401 no 878 0.27728715488963 1370 2977111
SGTC_2543 pimpinellin 60.67 µM 0.590906972552842 0.254572108982938 no 879 0.277291376954441 1300 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1976 st070609 63.5 µM 0.590734595887991 0.254626620019914 no 880 0.277349131892937 1312 682556
SGTC_1939 st074455 53.6 µM 0.590615588001964 0.254664257702192 no 881 0.277389009011681 1450 1644229
SGTC_636 0kpi-0074 126 µM 0.590455644242889 0.254714846437905 no 882 0.277442607322704 1333 616434
SGTC_1308 1187-1617 41.4 µM 0.589295966223837 0.255081799230796 no 883 0.27783137517053 1352 2882570
SGTC_2393 9031399 185.94 µM 0.588364123987224 0.25537685900077 no 884 0.27814395645901 1416 1526623 YDL150W RPC53
SGTC_3034 9090421 49.47 µM 0.588190283311092 0.255431923880533 no 885 0.278202289324038 1316 17173761
SGTC_5 0352-0601 109.883 µM 0.587443650507851 0.255668493981559 no 886 0.278452892461116 1288 762456
SGTC_603 3794-0023 45.9 µM 0.582709196717505 0.257171261269524 no 887 0.280044540538404 1386 3802260
SGTC_52 0329-0193 875 nM 0.581924563738978 0.257420755232338 no 888 0.280308747050599 1439 3739292
SGTC_3262 9137218 49.47 µM 0.581711260691355 0.257488602082525 no 889 0.280380592648116 1263 17650664
SGTC_71 0417-1750 47.813 µM 0.579141941239521 0.258306573426609 no 890 0.281246701073231 1464 6811472
SGTC_3305 9127027 53.8275 µM 0.577993216951751 0.25867271768319 no 891 0.281634349378581 1352 41905295
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.577325044210946 0.258885814516828 no 892 0.28185994929586 1416 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_293 4049-0273 38.5 µM 0.577058161247542 0.258970955479322 no 893 0.281950083220396 1315 1380311
SGTC_2406 ethylparaben 405.7 µM 0.575290313456841 0.259535299503687 no 894 0.282547485757194 1245 8434 A possible steroid mimic.
SGTC_829 1635-0120 117 µM 0.573026234210251 0.260258980150862 no 895 0.283313465637545 1438 285054
SGTC_1236 0330-0013 258 µM 0.572136656957859 0.260543605103438 no 896 0.283614698333182 1361 4617066
SGTC_1239 0337-0584 35.4 µM 0.571655081324232 0.260697754613039 no 897 0.28377783565574 1470 914301 YML130C ERO1
SGTC_304 1310-0298 97 µM 0.57137730192629 0.260786691493562 no 898 0.283871955918167 1324 1550234
SGTC_1588 farnesol 29.9 µM 0.570821406104301 0.260964720026659 no 899 0.284060355497295 1376 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1494 4358-1428 177 µM 0.570260697334603 0.26114435321944 no 900 0.284250446811111 1472 1564571
SGTC_3232 9132874 49.47 µM 0.56888768245996 0.261584491541083 no 901 0.284716182496383 1344 3784940
SGTC_2570 licareol 100 µM 0.567197949178844 0.262126680358518 no 902 0.28528985061558 1357 443158
SGTC_3287 9117173 37.0625 µM 0.567121321137239 0.262151281827754 no 903 0.285315879048879 1365 2789709
SGTC_2871 9038510 12.99 µM 0.567062715439835 0.262170098013248 no 904 0.285335786552067 1485 4945164
SGTC_722 3534-0461 190 µM 0.565722640668473 0.262600536656397 no 905 0.285791170895857 1344 658262
SGTC_459 nigericin 15.3 µM 0.565013177614487 0.26282856602529 no 906 0.286032400558832 1422 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_937 3122-0005 46.7 µM 0.564999251369193 0.262833043089592 no 907 0.286037136690345 1393 759535
SGTC_902 1120-0002 2.07 µM 0.564490308877093 0.262996686682933 no 908 0.286210246850223 1348 3280475
SGTC_3054 9094397 49.47 µM 0.559682972756639 0.264544985794733 no 909 0.28784784925164 1350 2598354
SGTC_2037 5169046 200 µM 0.558890043582623 0.264800809383831 no 910 0.288118382404817 1421 5718022
SGTC_2493 resveratrol 26.09 µM 0.55781132498076 0.265149039344963 no 911 0.288486614276574 1351 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1420 4'-methoxyflavone 42 µM 0.557566190953466 0.265228205480453 no 912 0.288570324256162 1410 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_411 enrofloxacin 100 µM 0.557273582006171 0.265322719371355 no 913 0.288670261264025 1528 71188 A bacterial gyrase inhibitor.
SGTC_2724 maprotiline 69.64 µM 0.554242583627449 0.266302748962567 no 914 0.289706419367893 1431 4011 A tricyclic antidepressant.
SGTC_3104 9120930 49.47 µM 0.55270988599305 0.266799021138938 no 915 0.290231041392007 1394 17014836
SGTC_1369 1866-0067 208 µM 0.551419120139216 0.267217320437632 no 916 0.29067319830113 1472 3531355
SGTC_3136 9095672 49.47 µM 0.550955850851025 0.267367533082425 no 917 0.290831969813481 1305 17217380
SGTC_669 0108-0021 26.2 µM 0.549033335300667 0.267991353536963 no 918 0.291491286597502 1655 17201
SGTC_2143 5623677 140.463 µM 0.548027044760593 0.268318167993489 no 919 0.291836666462337 1397 5375313
SGTC_770 0389-1121 67.2 µM 0.546155158030973 0.268926636224386 no 920 0.292479643604845 1512 6753108
SGTC_2443 5493264 126.67 µM 0.544896014790023 0.269336317804354 no 921 0.292912518663769 1487 5340055
SGTC_2027 5150920 200 µM 0.544534011178557 0.269454159129324 no 922 0.293037025226656 1440 786715
SGTC_1256 0570-0116 285 µM 0.543426177676365 0.269814947423021 no 923 0.293418202993693 1397 410638
SGTC_2398 5228213 48.84 µM 0.540045535307379 0.270917414824169 no 924 0.294582815015058 1496 80771 YMR134W ERG29
SGTC_852 0418-0143 439 µM 0.538784060766315 0.271329371681404 no 925 0.29501793152928 1443 5369229
SGTC_732 3970-1727 52.7 µM 0.537022418500541 0.271905189071192 no 926 0.295626064272506 1529 1275699
SGTC_957 1187-1561 14.1 µM 0.536524396685151 0.272068084611219 no 927 0.295798089733684 1408 1538454
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.536062138652141 0.272219325757557 no 928 0.295957802896531 1446 2724278 An inhibitor of dopamine biosynthesis.
SGTC_973 1325-0077 65.9 µM 0.533687171670072 0.272997023392143 no 929 0.296778993025426 1531 2835149
SGTC_2891 9063876 19.48 µM 0.532704777250333 0.273319036265563 no 930 0.297118979331848 1434 6472478
SGTC_2840 9008771 71.43 µM 0.530830680995543 0.273933855730121 no 931 0.297768058521833 1493 2992978
SGTC_2150 5556613 200 µM 0.529780450250944 0.274278695005919 no 932 0.298132080633841 1457 743190
SGTC_374 0880-0231 82.3 µM 0.529521291878017 0.274363821634009 no 933 0.298221939096514 1408 6833587
SGTC_1705 st027868 56.3335 µM 0.529461308547386 0.27438352642021 no 934 0.29824273898549 1494 292948
SGTC_84 0443-0269 128.823 µM 0.525346413532972 0.275736952661072 no 935 0.299671198872941 1414 6150058
SGTC_1731 st035964 63 µM 0.524878183841442 0.275891165322644 no 936 0.299833938080591 1465 6739575
SGTC_2796 7949634 45.45 µM 0.524214749430127 0.276109741686207 no 937 0.300064591665376 1414 2971588
SGTC_2331 7980721 200 µM 0.52269635230522 0.276610315397267 no 938 0.300592788535628 1508 2981221
SGTC_132 0417-1715 25.805 µM 0.522635619661343 0.276630346524908 no 939 0.300613924011385 1551 6769098
SGTC_246 cycloheximide 667 µM 0.521400870488572 0.277037751419483 no 940 0.301043772599471 1391 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3030 9087619 49.47 µM 0.521362416968351 0.277050443853848 no 941 0.301057163726191 1413 25236973
SGTC_1933 st074711 15.9 µM 0.520825758825045 0.277227609433889 no 942 0.30124407858655 1406 17250958
SGTC_3137 9097352 49.47 µM 0.520104845051026 0.277465690045742 no 943 0.30149525082774 1533 44120435
SGTC_3016 9080866 49.47 µM 0.51909177325671 0.277800424178901 no 944 0.301848372475521 1422 17066299
SGTC_2383 9036125 200 µM 0.518372308357879 0.278038265861057 no 945 0.302099265769609 1467 79580
SGTC_1615 st002656 86.5 µM 0.517242504494689 0.278411958339802 no 946 0.30249344215865 1430 1584458
SGTC_763 3453-1109 128 µM 0.515891634052859 0.278859091541193 no 947 0.302965048718293 1458 1560353
SGTC_193 1273-0060 1.558 µM 0.514968811056967 0.279164743348481 no 948 0.303287407363031 1384 2847393 YHR072W ERG7
SGTC_2875 9039966 71.43 µM 0.513519001588346 0.279645269070986 no 949 0.30379416123729 1567 6463691
SGTC_2933 9026794 32.47 µM 0.512374952230471 0.280024736645201 no 950 0.304194308822488 1519 17586027
SGTC_2179 6298986 200 µM 0.511413037826338 0.280343985267887 no 951 0.304530933696541 1554 738374
SGTC_284 0988-0104 32.6 µM 0.509443070515418 0.280998344935197 no 952 0.30522084647125 1502 4666532
SGTC_442 cape 100 µM 0.50825522583415 0.281393265028109 no 953 0.305637182812883 1569 5281787
SGTC_1324 1418-0026 34.4 µM 0.508011633867298 0.281474284594924 no 954 0.305722592218622 1493 1372513
SGTC_2738 aclarubicin 5.55 µM 0.507573473411306 0.281620046666338 no 955 0.305876248781874 1482 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2346 9031566 143.75 µM 0.507425967278716 0.281669125461669 no 956 0.305927984749316 1542 4771086
SGTC_863 0466-0191 129 µM 0.505567598701503 0.28228780185084 no 957 0.306580116189525 1488 765160 YPR165W RHO1
SGTC_2896 9052656 71.43 µM 0.504853671144514 0.282525651855729 no 958 0.306830807928942 1435 6469436
SGTC_534 k292-0788 63.4 µM 0.503505661181886 0.282975013442092 no 959 0.307304400560253 1535 4146317
SGTC_3089 9117425 49.47 µM 0.500515712281826 0.283972941174986 no 960 0.308355997727753 1417 9401657
SGTC_2473 5854593 8.94 µM 0.499633267605507 0.284267788128017 no 961 0.308666664321668 1460 2872951
SGTC_2953 9074162 66.49 µM 0.498546593696724 0.284631074143042 no 962 0.309049418480678 1600 16451992
SGTC_2239 6685329 187.64 µM 0.497868031036141 0.284858036831676 no 963 0.309288530708924 1478 805680
SGTC_169 k015-0017 16.025 µM 0.497011563684674 0.28514462751382 no 964 0.309590448409712 1571 1840002
SGTC_3215 9129942 49.47 µM 0.494694251564565 0.285920733542075 no 965 0.310407979938328 1496 17682944
SGTC_2504 purpurogallin 52.29 µM 0.491355812294882 0.287040594127535 no 966 0.311587405711925 1483 5281571 An antioxidant.
SGTC_3103 9120822 49.47 µM 0.489761746661285 0.287576046170984 no 967 0.312151251315923 1564 17141819
SGTC_1816 st051957 91.6 µM 0.489130426483586 0.287788239213535 no 968 0.312374680801911 1500 674121
SGTC_2991 9074669 71.4286 µM 0.488571845410828 0.287976045562278 no 969 0.312572424850374 1590 17333109
SGTC_2603 homopterocarpin 100 µM 0.487472497844803 0.288345837533848 no 970 0.312961763982768 1509 101795 A weak amylase inhibitor.
SGTC_333 3486-0131 40.1 µM 0.486699618139221 0.288605948153763 no 971 0.313235607941405 1600 6744690
SGTC_567 1080-0542 68.4 µM 0.485220655175286 0.289103997122038 no 972 0.313759915885397 1531 5950415
SGTC_1268 0828-0275 2.46 µM 0.484685049240862 0.289284465028736 no 973 0.313949886712143 1550 745337
SGTC_75 0159-0059 199.013 µM 0.484531734633646 0.289336132838894 no 974 0.31400427402384 1597 5377270
SGTC_268 camptothecin 39.6153 µM 0.484388854877785 0.289384287953838 no 975 0.3140549632804 1511 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1658 st012944 20 µM 0.48317060547672 0.28979503038532 no 976 0.314487302363893 1530 24207260
SGTC_1304 1165-0502 251 µM 0.482944326125878 0.289871352369544 no 977 0.314567633678021 1532 767425
SGTC_2160 5660466 132.927 µM 0.482843850940985 0.289905244765514 no 978 0.31460330613567 1539 2859134
SGTC_1969 st069479 40.1 µM 0.481490365568393 0.290361984922036 no 979 0.315084012757391 1591 3895485
SGTC_2226 7298446 200 µM 0.479246600241446 0.291119895715088 no 980 0.315881603050868 1572 3283010
SGTC_1862 st057513 3.81 µM 0.477871925999437 0.291584696323823 no 981 0.316370682030542 1497 5393163
SGTC_2536 dehydroabietamide 32.04 µM 0.475521140055973 0.292380337574432 no 982 0.317207784503461 1636 3983547
SGTC_3283 9109332 35.8195 µM 0.475464178699603 0.292399629095873 no 983 0.317228079774631 1458 17027281
SGTC_1656 st012921 11 µM 0.475134746505946 0.292511211926456 no 984 0.317345466898146 1549 6732821
SGTC_19 0279-0214 38.434 µM 0.474684207213382 0.292663847287662 no 985 0.317506038064406 1541 3566274 YBR002C RER2
SGTC_1255 0566-0045 221 µM 0.471529947250648 0.293733493823771 no 986 0.318631169544584 1589 2788469
SGTC_1911 st060208 74.3 µM 0.471054474541025 0.293894888975541 no 987 0.318800917169176 1611 688783
SGTC_1975 st070967 30.8 µM 0.470030774669267 0.294242514297752 no 988 0.319166515370825 1606 261391
SGTC_2476 5806916 10.51 µM 0.469881500845962 0.294293220175221 no 989 0.31921984086012 1562 2870194
SGTC_2837 9008476 45.46 µM 0.469877785748904 0.294294482184425 no 990 0.31922116806194 1563 2992805
SGTC_109 0132-0036 33.701 µM 0.469089182822247 0.294562425188686 no 991 0.319502945352245 1470 67274 A color developer.
SGTC_660 4031-1742 102 µM 0.467333606585742 0.295159319813046 no 992 0.320130607997697 1513 6738706
SGTC_258 haloperidol 50.781 µM 0.466053409433627 0.295594936716238 no 993 0.32058863556289 1472 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_992 3909-8734 162 µM 0.4651074047446 0.295917026624797 no 994 0.320927271773318 1514 4288319
SGTC_3306 9127676 59.7925 µM 0.46497545935033 0.295961963391687 no 995 0.320974515404577 1516 41905287
SGTC_3065 9113888 49.47 µM 0.46434867982935 0.296175469059291 no 996 0.321198976157535 1591 16648368
SGTC_2176 5809774 33.9695 µM 0.463517682296989 0.29645864827837 no 997 0.321496671693056 1592 2870539
SGTC_2078 5212016 200 µM 0.462689244483127 0.296741078673285 no 998 0.321793564398017 1583 1899708
SGTC_2 0422-0095 29 µM 0.46230283520441 0.296872855150081 no 999 0.321932083368018 1474 6790840
SGTC_2888 9058547 12.99 µM 0.461055970495019 0.297298253742252 no 1000 0.322379224791069 1485 16476514
SGTC_2193 5925765 200 µM 0.460866713335435 0.297362847820952 no 1001 0.322447117286812 1585 877370
SGTC_3047 9092122 49.47 µM 0.460233592701421 0.297578980517288 no 1002 0.322674280602453 1496 17173831
SGTC_493 zm226600 134 µM 0.459148697841851 0.2979495050689 no 1003 0.323063694122 1556 5240098 A potassium channel opener. YCR052W RSC6
SGTC_656 4090-1979 187 µM 0.457684006893395 0.298450074873449 no 1004 0.323589739859639 1647 22330961
SGTC_1151 3909-8316 15.3 µM 0.455873704264514 0.299069288428812 no 1005 0.324240399842392 1528 800431
SGTC_3297 9117502 71.43 µM 0.455575336837616 0.299171400895036 no 1006 0.324347690840095 1546 7453720
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.455266349258467 0.299277164648242 no 1007 0.32445881614867 1575 688662
SGTC_2369 9071472 200 µM 0.45356183804582 0.299860908597197 no 1008 0.32507211292497 1605 17296037
SGTC_2064 5220758 200 µM 0.451266327417982 0.300647865530641 no 1009 0.325898805288221 1578 788518
SGTC_43 0570-0105 72.5 µM 0.450760627096079 0.300821357147026 no 1010 0.326081040663923 1601 1114046 YDL195W SEC31
SGTC_2941 9056145 11.23 µM 0.448415787463952 0.301626395469485 no 1011 0.326926575016437 1487 2119517
SGTC_672 1441-0018 53.7 µM 0.447212003368261 0.302040058782475 no 1012 0.327360997733854 1515 251141
SGTC_2031 5180455 200 µM 0.443574104163482 0.303291716632422 no 1013 0.328675265806705 1532 29949
SGTC_1540 guanosine 70.6 µM 0.43990607721075 0.304556082257491 no 1014 0.3300025670816 1593 6802 Guanosine is a purine nucleoside
SGTC_2166 5933061 31.504 µM 0.439550961957141 0.30467861457741 no 1015 0.330131182059244 1715 2877375
SGTC_683 panaxydol 45 µM 0.439240837003876 0.304785640947573 no 1016 0.330243518957526 1649 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1950 st077106 7.18 µM 0.43853936677169 0.305027785036175 no 1017 0.330497669722445 1532 13831864
SGTC_1746 st038117 42 µM 0.43828889093513 0.30511426876285 no 1018 0.330588438960977 1582 2898218
SGTC_3066 9117245 49.47 µM 0.438049465213413 0.305196947305513 no 1019 0.330675213094845 1667 17176980
SGTC_725 1497-0963 19 µM 0.437903081734493 0.305247501377917 no 1020 0.330728270773815 1703 3549977
SGTC_3336 9143619 71.43 µM 0.437787392598208 0.30528745767481 no 1021 0.33077020548758 1605 45595730
SGTC_652 0437-0092 114 µM 0.437550434697003 0.305369304583398 no 1022 0.330856104035044 1531 3091274
SGTC_2074 5212007 75.395 µM 0.436458987921779 0.305746423479076 no 1023 0.331251874448696 1676 758611
SGTC_3007 9078383 71.4286 µM 0.432893506871085 0.306979810495258 no 1024 0.332546068696458 1577 6496995
SGTC_2083 5306046 65.942 µM 0.432649517535402 0.307064292495711 no 1025 0.3326347049 1559 539837
SGTC_2055 5235184 200 µM 0.431993540501874 0.30729147718995 no 1026 0.332873053969675 1586 2836034
SGTC_107 0358-0022 2.6945 µM 0.431269031827757 0.307542482433092 no 1027 0.333136382495338 1657 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_794 k038-0031 316 µM 0.430741163723994 0.307725418534237 no 1028 0.333328292245294 1564 6624242
SGTC_2102 5377816 72.7585 µM 0.427333656417522 0.308907461124762 no 1029 0.334568161025064 1704 1379702
SGTC_546 peri-Naphthalide 147 µM 0.425642369500424 0.309494894589028 no 1030 0.335184230883853 1677 223824 A penicillin ester.
SGTC_486 niguldipine 82 µM 0.424376314727742 0.309934951376382 no 1031 0.335645695697581 1604 1236 A calcium channel blocker.
SGTC_2020 4017018 200 µM 0.424228707894529 0.309986274475832 no 1032 0.33569951312595 1577 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1231 0242-0792 125 µM 0.423757964856374 0.310149977209929 no 1033 0.335871168471774 1562 3707635
SGTC_2513 baicalein 25.65 µM 0.423757814082756 0.310150029648075 no 1034 0.335871223456508 1500 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2546 rhodinyl acetate 100 µM 0.422895035042813 0.310450162135872 no 1035 0.3361859227099 1718 6708682
SGTC_575 k072-0246 11.9 µM 0.42105214594074 0.311091665365731 no 1036 0.336858502181786 1616 6796779
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.42050443147104 0.311282433654244 no 1037 0.33705849638513 1644 17037758
SGTC_781 4335-2806 94.4 µM 0.420397067057998 0.311319834493945 no 1038 0.337097705170082 1721 845254
SGTC_382 3229-0966 23.2 µM 0.416154589921331 0.312799274861381 no 1039 0.338648443008888 1683 5722370
SGTC_1875 nocodazole 6 µM 0.415615387963922 0.312987522671331 no 1040 0.338845732369089 1663 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1143 3454-2408 5.08 µM 0.411013413699537 0.314596157919939 no 1041 0.340531349484707 1597 X1143
SGTC_644 1498-1197 63.3 µM 0.409804791359089 0.315019221668322 no 1042 0.34097457558701 1672 6741615
SGTC_1124 fisetin 1.16336 µM 0.408789620870451 0.315374757567342 no 1043 0.341347028706453 1578 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2120 5538279 151.968 µM 0.40821383251129 0.315576487838527 no 1044 0.341558346849761 1631 2058197
SGTC_1989 st071868 50.2 µM 0.408019742952145 0.315644500456663 no 1045 0.341629590201573 1725 16414057
SGTC_73 0327-0325 16.231 µM 0.407684787771434 0.315761889713735 no 1046 0.341752553566104 1765 53298
SGTC_316 k060-0003 58.6 µM 0.406513807747504 0.316172420405409 no 1047 0.342182556832308 1682 6152314
SGTC_1315 1237-0019 3.69 µM 0.40595634384319 0.316367939848807 no 1048 0.34238733877999 1694 825140
SGTC_2116 5511452 16.8835 µM 0.405468935101191 0.31653893090181 no 1049 0.342566424247252 1642 870744
SGTC_2557 derrustone 83.84 µM 0.40473144272342 0.316797729990631 no 1050 0.342837463625973 1559 629853 An antioxidant.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.404634129879027 0.316831885485004 no 1051 0.342873233583874 1571 4174840
SGTC_1811 st050069 61.5 µM 0.403584995018073 0.317200216755772 no 1052 0.343258960759539 1666 3877702
SGTC_1034 k072-0165 12.7 µM 0.403068956575712 0.31738145451509 no 1053 0.343448748519737 1757 5835461
SGTC_152 4469-0003 551.229 µM 0.402827632778665 0.317466224829252 no 1054 0.343537515735379 1651 697280
SGTC_3095 9117207 49.47 µM 0.402711567801278 0.317506998626024 no 1055 0.343580211510628 1743 17015229
SGTC_490 phenamil 164 µM 0.401481592042763 0.317939226891965 no 1056 0.344032794126871 1714 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2890 9046729 58.44 µM 0.399782413281087 0.318536746849784 no 1057 0.344658392567722 1565 903329
SGTC_1429 4049-0205 9.46 µM 0.398921277709342 0.318839747489997 no 1058 0.344975605241168 1637 22774478
SGTC_3011 9081274 71.4286 µM 0.398637945880877 0.31893946760725 no 1059 0.345079998763207 1615 6625322
SGTC_1047 2043-3044 82 µM 0.398208136677912 0.319090766223917 no 1060 0.345238384336351 1570 669592
SGTC_564 3555-0129 330 µM 0.398191537143449 0.319096610087856 no 1061 0.345244501842749 1641 563260
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.398141728848814 0.319114145361313 no 1062 0.345262858176197 1595 115019
SGTC_697 0508-1955 564 µM 0.397807131396536 0.319231952654025 no 1063 0.345386180051986 1736 6243113
SGTC_3200 9114385 49.47 µM 0.397211119632453 0.319441845648191 no 1064 0.345605891504756 1575 17018030 YLR208W SEC13
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.395758272147714 0.319953726393821 no 1065 0.346141681362596 1608 279621
SGTC_2876 9059903 25.97 µM 0.39574432852511 0.319958640803903 no 1066 0.346146825070306 1625 6916095
SGTC_2322 7413319 38.22 µM 0.395625973449183 0.320000356155386 no 1067 0.346190486597122 1662 1840400
SGTC_1012 4112-3522 18 µM 0.395520387034993 0.320037572993762 no 1068 0.346229439453551 1745 3112398
SGTC_2376 9072922 81.32 µM 0.392937409212105 0.32094857793463 no 1069 0.347182855360632 1652 17087968
SGTC_1085 doxorubicin 7.67 µM 0.390822817939226 0.321695188607886 no 1070 0.347964103733718 1748 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_991 3996-0057 64.7 µM 0.390431758914461 0.321833341071221 no 1071 0.348108653684682 1644 715343
SGTC_3181 9108277 49.47 µM 0.390367624021808 0.321856000855335 no 1072 0.348132362432116 1602 17097298
SGTC_225 nsc-122657 1.016 µM 0.388735982725019 0.322432705928637 no 1073 0.348735730730285 1672 275685
SGTC_2948 9070189 9.45 µM 0.388226733466491 0.322612788149404 no 1074 0.348924125608094 1748 6473636 YDL196W YDL196W
SGTC_1008 4106-0037 6 µM 0.387627847452587 0.322824621233997 no 1075 0.349145728930769 1653 2905394
SGTC_1548 st061468 90.8 µM 0.381253995198105 0.325082679412623 no 1076 0.351507393389467 1730 390799
SGTC_2508 celastrol 40.54 µM 0.381072258948728 0.325147157735719 no 1077 0.351574815651301 1611 122724 Celastrol is a natural product and antioxidant.
SGTC_2616 abietic acid 100 µM 0.380676501087293 0.325287587041563 no 1078 0.351721653862671 1788 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_262 fenpropimorph 62.5 µM 0.378416858942366 0.326089865189591 no 1079 0.352560473055715 1617 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_918 glabranin 770.725 nM 0.377728094106955 0.326334569151828 no 1080 0.352816297629506 1707 124049 Also referred to as licorice root.
SGTC_2389 9091542 195.52 µM 0.376152928015269 0.326894474125084 no 1081 0.353401603932111 1639 3626624 YOL127W RPL25
SGTC_921 1561-0023 372 µM 0.375515453735733 0.327121180206363 no 1082 0.353638577762119 1608 24050882
SGTC_196 k015-0023 18.111 µM 0.374456300716811 0.327497989665921 no 1083 0.354032431277392 1660 5211998
SGTC_1808 st050063 61.5 µM 0.373106709601035 0.327978381491167 no 1084 0.354534512569504 1735 4011993
SGTC_2773 thioridazine 9.09 µM 0.372423369841605 0.328221727381262 no 1085 0.354788828356343 1686 5452 An antipsychotic.
SGTC_838 0109-0203 71.4 µM 0.371701527144843 0.328478863845691 no 1086 0.355057543926162 1657 759422
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.371175529017006 0.328666287294857 no 1087 0.35525339916721 1688 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_400 oxethazaine 37.5 µM 0.37095467954756 0.32874499314416 no 1088 0.355335643801009 1654 4621 A local anesthetic.
SGTC_2272 7805186 180 µM 0.369421416194746 0.32929162345127 no 1089 0.355906818685408 1774 2956062 YPR165W RHO1
SGTC_291 SEC14.278 35.5 µM 0.368556286638462 0.329600215709647 no 1090 0.356229241678105 1760 1068044
SGTC_1771 st048882 4.1505 µM 0.368218194001596 0.329720845119405 no 1091 0.356355272540268 1602 4580403
SGTC_661 1304-0007 33.6 µM 0.366732893844276 0.330251000965589 no 1092 0.356909133902389 1647 3117130
SGTC_3271 9137798 49.47 µM 0.366669361623466 0.330273685460214 no 1093 0.356932831502921 1784 6498326
SGTC_3118 9124250 49.47 µM 0.365818639010269 0.330577500264167 no 1094 0.357250205293177 1656 1504786
SGTC_736 0958-0254 92.6 µM 0.364939106197786 0.33089172134272 no 1095 0.357578430982898 1724 6812352
SGTC_3182 9108849 49.47 µM 0.364302061913046 0.331119385628757 no 1096 0.357816230164073 1699 17133045
SGTC_561 1550-0330 72.9 µM 0.36232433111731 0.331826576561588 no 1097 0.358554839017894 1653 6812934
SGTC_1114 scopoletin 1.73284 µM 0.362047578738606 0.331925584715035 no 1098 0.358658238018606 1798 5280460 A coumarin with genotoxic properties.
SGTC_2480 5767542 37.17 µM 0.361613953319239 0.332080737794584 no 1099 0.358820268063569 1735 2867358
SGTC_1119 parthenolide 318.541 nM 0.361371228654577 0.332167598316571 no 1100 0.358910976534853 1760 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3101 9120531 49.47 µM 0.36098546004021 0.332305666553869 no 1101 0.359055158234643 1773 24824904
SGTC_751 0833-0568 350 µM 0.360704209969781 0.332406341505003 no 1102 0.359160288601632 1709 6954252
SGTC_601 0986-0029 62.9 µM 0.358804367673182 0.333086716526273 no 1103 0.359870722509795 1692 24747981
SGTC_3237 9133362 49.47 µM 0.35851161254782 0.333191607471208 no 1104 0.359980239554518 1741 43845137
SGTC_2192 5915882 198.485 µM 0.358200515238572 0.33330308451982 no 1105 0.360096630842122 1690 2876149
SGTC_1441 4106-0040 13 µM 0.358064856619374 0.333351700360218 no 1106 0.360147389059968 1690 2904180
SGTC_2420 aureobasidin a 50 nM 0.356882389680425 0.33377557830375 no 1107 0.360589926858728 1815 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1766 st045414 44.774 µM 0.356017974993066 0.334085578632631 no 1108 0.360913551940017 1687 253960
SGTC_2675 theaflavin digallate 100 µM 0.355958246260754 0.334107003007009 no 1109 0.360935917245194 1696 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2737 bleomycin 30.5 nM 0.354426889042568 0.334656477018528 no 1110 0.361509493099408 1699 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_15 0266-0086 27.098 µM 0.353446613227435 0.335008400796318 no 1111 0.361876822794288 1788 1712902 YIL048W NEO1
SGTC_2553 4-methylesculetin 85.09 µM 0.350099315481479 0.33621118761648 no 1112 0.363132082296422 1648 5319502
SGTC_1449 4112-4002 201 µM 0.349639385451318 0.336376586036419 no 1113 0.36330467448969 1648 2059539
SGTC_445 e6 berbamine 66 µM 0.348993017017284 0.336609084304561 no 1114 0.363547275999469 1691 6610268 A calcium/calmodulin antagonist.
SGTC_2497 7-hydroxyflavone 100 µM 0.344802664103235 0.338117863209385 no 1115 0.365121365051678 1791 5281894
SGTC_635 k038-0028 24.7 µM 0.343957038741597 0.338422655683534 no 1116 0.365439297561211 1757 4035102
SGTC_704 1310-0270 142 µM 0.343365938767917 0.338635771341614 no 1117 0.36566159026697 1655 5718033
SGTC_2309 7664088 163.95 µM 0.341989949287141 0.339132071767105 no 1118 0.366179228022609 1865 704922
SGTC_249 wiskostatin 11.211 µM 0.340847469615276 0.339544360679807 no 1119 0.366609206167302 1806 2775510 A n-wasp and actin depolymerizer.
SGTC_2195 6536160 144.242 µM 0.339063536564687 0.340188516173093 no 1120 0.367280933338079 1677 3834386
SGTC_1729 st035615 45.989 µM 0.338692546491795 0.340322534641511 no 1121 0.367420678096255 1703 17385451
SGTC_2713 st079149 53.4 µM 0.337393511640467 0.340791963917489 no 1122 0.367910137588605 1742 3103253
SGTC_468 gf-109203x 121 µM 0.336887121160529 0.340975023952167 no 1123 0.368100997122339 1823 2396 A protein kinase C inhibitor.
SGTC_1045 1348-1485 165 µM 0.336576479700162 0.341087339297879 no 1124 0.368218094596108 1711 6810614
SGTC_1723 st034307 2.5525 µM 0.334159695038082 0.341961630859485 no 1125 0.369129528116771 1684 867466
SGTC_1495 4469-0029 237 µM 0.331858180388038 0.342795011158256 no 1126 0.36999817485117 1696 793680
SGTC_1993 st073995 70.8 µM 0.331539123627822 0.342910602379562 no 1127 0.370118646986464 1756 3098394
SGTC_2079 5212404 121 µM 0.33006048208867 0.343446491954081 no 1128 0.370677131113376 1860 758462
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.328796388218142 0.343904874825936 no 1129 0.371154796613555 1798 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2656 pseudo-anisatin 100 µM 0.328096220354869 0.344158866940159 no 1130 0.371419455843078 1758 6708809 A neurotoxin.
SGTC_182 3448-4371 550.524 µM 0.327189706857302 0.344487817213711 no 1131 0.371762202786389 1925 3491403
SGTC_646 4092-0839 27.3 µM 0.327025094672513 0.344547563341709 no 1132 0.371824452513535 1824 877796
SGTC_2981 9013952 38.96 µM 0.324023469664055 0.345637684407903 no 1133 0.372960132880424 1628 2996344
SGTC_3246 9135460 32.98 µM 0.323962887299633 0.345659699747825 no 1134 0.372983065939823 1807 41446951
SGTC_1855 st056195 39.6 µM 0.32338666280236 0.345869123043074 no 1135 0.373201214458985 1854 4028379
SGTC_2517 totarol 10 µM 0.322752448636991 0.346099676650798 no 1136 0.373441363847184 1687 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1326 1431-2094 10.8 µM 0.32211606694187 0.346331075564915 no 1137 0.373682383399288 1692 616278
SGTC_2298 7976326 193.81 µM 0.320865063795134 0.346786128185022 no 1138 0.374156325110666 1798 2235818
SGTC_341 1486-1430 230 µM 0.320450477782222 0.346936982735025 no 1139 0.374313432757728 1695 2054753 YPL210C SRP72
SGTC_161 4065-0411 162.148 µM 0.316611801078886 0.348334903701081 no 1140 0.375769090085722 1779 1906281 YLR208W SEC13
SGTC_2463 5473429 200 µM 0.313316162125906 0.349536714755082 no 1141 0.377020236133338 1740 5399405
SGTC_2489 cantharidin 73.42 µM 0.312398644038988 0.349871572584988 no 1142 0.377368790371342 1693 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3224 9130643 49.47 µM 0.311614005535266 0.350158027287094 no 1143 0.377666944504214 1816 17644395
SGTC_1881 5652484 16 µM 0.311172711777045 0.350319171658679 no 1144 0.377834663396823 1874 2255129
SGTC_417 st075190 100 µM 0.30886213936771 0.351163347705457 no 1145 0.378713198998835 1897 222757
SGTC_3067 9117431 49.47 µM 0.308397617481413 0.351333151332412 no 1146 0.37888989732965 1743 17150885
SGTC_1180 1193-0155 285 µM 0.307884238498831 0.351520848948211 no 1147 0.379085209738062 1741 2921347
SGTC_721 1187-1332 279 µM 0.306971712014178 0.351854569113729 no 1148 0.379432451953871 1740 25730
SGTC_1398 3558-0053 112 µM 0.304387605460969 0.352800221691779 no 1149 0.380416304749074 1761 4532369
SGTC_726 3448-4391 34.2 µM 0.304263541554485 0.352845645763332 no 1150 0.380463559407807 1864 1356692
SGTC_3020 9089140 49.47 µM 0.303480698803316 0.353132319827351 no 1151 0.380761777227504 1749 17217859
SGTC_457 grayanotoxin iii 135 µM 0.303129780551156 0.353260851840547 no 1152 0.380895479799961 1820 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1203 3992-3522 103 µM 0.302134166907898 0.353625609689468 no 1153 0.381274893682448 1975 5322312
SGTC_2025 5147754 141 µM 0.299907180859409 0.354441985366349 no 1154 0.382123978393135 1870 315777 YLR208W SEC13
SGTC_231 b-estradiol 524 µM 0.299589989029459 0.354558317094876 no 1155 0.382244960612638 1738 450 A steroid.
SGTC_1090 efavirenz 20.7 µM 0.299336162786995 0.354651418943021 no 1156 0.382341782429101 1832 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3247 9135149 49.47 µM 0.298894400567894 0.354813475214375 no 1157 0.382510309813456 1802 8934436 YOR116C RPO31
SGTC_1662 st014054 52 µM 0.297584544055582 0.355294137984211 no 1158 0.383010136238306 1829 2838777
SGTC_2711 st079103 59.1 µM 0.295413823549041 0.356091208757495 no 1159 0.383838887303509 1886 54693780
SGTC_2910 7948405 25.97 µM 0.295395445300589 0.356097959791014 no 1160 0.383845906139098 1913 2971328
SGTC_666 0272-0154 136 µM 0.295179860786303 0.356177155595921 no 1161 0.383928242850503 1816 6870312
SGTC_1489 4065-0444 182 µM 0.293878789864228 0.356655240635558 no 1162 0.384425263031638 1924 2877968
SGTC_2456 5770359 74.46 µM 0.293232176393606 0.356892925854505 no 1163 0.384672345642618 1877 3118787
SGTC_3340 9146634 11.102 µM 0.292756165710172 0.357067935612878 no 1164 0.3848542678137 1769 4907387
SGTC_3351 9150312 21.596 µM 0.292604911966316 0.357123551758686 no 1165 0.384912079409006 1836 4904905
SGTC_3338 9144300 39.5675 µM 0.291611439113236 0.357488928083786 no 1166 0.385291864131776 1851 4901274
SGTC_1167 k781-0610 148 µM 0.291097983523028 0.357677816407417 no 1167 0.385488191048841 1791 4525169
SGTC_2977 9011197 71.43 µM 0.290457221953714 0.357913586523674 no 1168 0.385733236342364 1864 2704722
SGTC_1227 3909-8010 46.6 µM 0.290157447192458 0.35802390815362 no 1169 0.385847894331072 1811 15982272
SGTC_1038 k292-0204 154 µM 0.289997902095912 0.358082627988785 no 1170 0.385908921280248 1743 4454212
SGTC_2841 9004761 38.96 µM 0.286652339842706 0.35931471812153 no 1171 0.387189266979001 1658 2991039
SGTC_1843 st055809 45.5 µM 0.286298388104808 0.359445155913921 no 1172 0.387324796294185 1806 16413835
SGTC_3333 9141820 12.094 µM 0.285924928705595 0.359582800400886 no 1173 0.387467810049408 1773 1939433
SGTC_1210 3013-0140 750 nM 0.285822318009221 0.359620622419868 no 1174 0.387507106798007 1941 905973
SGTC_1363 1636-0063 10.4 µM 0.283776780846376 0.360374888249726 no 1175 0.388290724769412 1803 6072185
SGTC_140 0062-0056 502.533 µM 0.283117197081309 0.360618217448661 no 1176 0.388543499659317 1745 3758964
SGTC_939 1165-0479 45.3 µM 0.28005096125646 0.361750132242239 no 1177 0.389719203525051 1945 1377347
SGTC_1351 1496-0003 46.5 µM 0.2796866829013 0.361884687891051 no 1178 0.38985894812497 1896 3891978
SGTC_1161 k007-0610 110 µM 0.276807465228647 0.362948801152015 no 1179 0.390963974326875 1921 5843850
SGTC_2113 5491891 107.031 µM 0.275384643907472 0.363475044899406 no 1180 0.391510370278213 1740 789979
SGTC_3045 9092950 49.47 µM 0.275338992581364 0.363491933741111 no 1181 0.391527904983167 1951 44120432
SGTC_3063 1327-0034 4 µM 0.27475468608705 0.363708123058908 no 1182 0.391752356951758 1895 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3083 9117465 49.47 µM 0.274238356391138 0.363899197560521 no 1183 0.391950726717623 1757 16420915
SGTC_702 1488-0190 94 µM 0.273774168675436 0.364071005140171 no 1184 0.392129087929208 1956 949357
SGTC_1456 k015-0012 13 µM 0.273682430866036 0.364104962851653 no 1185 0.392164340289511 1996 2989616
SGTC_1301 naphtanilide LB 4.81 µM 0.273516220586591 0.364166490046049 no 1186 0.392228212661239 1918 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.27219441396082 0.364655916747215 no 1187 0.392736268379432 1780 803109
SGTC_1726 st035556 14.5795 µM 0.271586632593569 0.364881034693566 no 1188 0.392969939450712 1919 5919439
SGTC_2445 5742597 35.57 µM 0.269495871480687 0.36565579326386 no 1189 0.393774059409862 1797 1774255
SGTC_112 phenothiazine 287.218 µM 0.269410963623772 0.365687268576089 no 1190 0.393806725107538 1964 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_792 4534-1957 155 µM 0.268793106069384 0.365916335370437 no 1191 0.394044449368787 1849 1717904
SGTC_3150 9097574 49.47 µM 0.26855294844028 0.366005385204981 no 1192 0.394136862063924 1941 17217476
SGTC_1839 st053978 48 µM 0.268502676656239 0.366024026767743 no 1193 0.394156207409269 1943 3788398
SGTC_1496 4469-0713 57.4 µM 0.267792015074421 0.366287585000508 no 1194 0.394429708685808 1943 746691
SGTC_103 0844-0104 51.839 µM 0.266878241261848 0.366626562782028 no 1195 0.394781455088872 1921 5375804
SGTC_1002 4049-0206 172 µM 0.266533433175033 0.366754501448016 no 1196 0.394914207185332 1796 4662749
SGTC_1750 st081859 2.357 µM 0.266298259930007 0.366841769353578 no 1197 0.395004756554571 1854 5291695
SGTC_1476 4112-3294 3.34 µM 0.265780372881273 0.367033970738664 no 1198 0.395204179946718 1912 704369
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.262985430969937 0.36807182077287 no 1199 0.396280904194416 1797 6708514
SGTC_1553 gossypol 38.6 µM 0.261892644036321 0.368477869488931 no 1200 0.396702105478216 1887 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1501 4491-0275 38.4 µM 0.259944807717777 0.369201994444206 no 1201 0.397453173696323 1968 5104718
SGTC_1740 st038286 13.222 µM 0.258297590772439 0.369814724093009 no 1202 0.398088622741289 1883 716786
SGTC_1296 1068-0102 11.9 µM 0.25724473663537 0.370206536755793 no 1203 0.398494925429176 1942 767053
SGTC_1721 st082152 9.2685 µM 0.255081237830029 0.371012090906034 no 1204 0.399330177494575 1848 5296051
SGTC_2963 9082507 9 µM 0.254931861406407 0.37106773042941 no 1205 0.399387863623744 1878 16459611
SGTC_1052 3253-3998 198 µM 0.253353886077786 0.371655656912813 no 1206 0.39999737946326 1883 5450317
SGTC_2776 terbinafine 19.92 µM 0.25293646412534 0.371811231303896 no 1207 0.400158655563855 1920 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_313 3474-0040 5.03 µM 0.251794709753418 0.372236873398217 no 1208 0.400599873307079 1831 1043375 YIL048W NEO1
SGTC_3106 9121286 49.47 µM 0.251046049891774 0.372516056006545 no 1209 0.400889253131998 1967 15943471
SGTC_2490 carminic acid 95.39 µM 0.250688172694111 0.372649535602552 no 1210 0.401027602786963 1886 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1968 st069590 43.6 µM 0.247853568863456 0.373707313870309 no 1211 0.402123852885335 1953 6384066
SGTC_2659 sanguinarine 24.21 µM 0.247691890469722 0.373767675551702 no 1212 0.402186403429789 1871 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1390 3413-2614 145 µM 0.24593734351198 0.374422924214777 no 1213 0.402865367749304 1849 3421432
SGTC_297 0986-0032 24 µM 0.245301174274635 0.374660596101165 no 1214 0.403111621291667 1875 2847425
SGTC_799 1310-0557 151 µM 0.24485989939075 0.374825483724042 no 1215 0.403282456128817 1888 5354492
SGTC_1305 1181-0477 144 µM 0.24430854301918 0.375031536765758 no 1216 0.403495933770993 1992 6252086
SGTC_2819 7996655 46.38 µM 0.243662019428749 0.375273201161402 no 1217 0.403746295485122 1953 6456960
SGTC_1672 st016598 6.51 µM 0.242426169475012 0.375735286347359 no 1218 0.404224979366889 1843 4665860 YNL267W PIK1
SGTC_1317 1273-0028 910 nM 0.241959578232483 0.375909791545267 no 1219 0.404405742289867 1871 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2898 9056270 58.44 µM 0.24097313131543 0.376278806357479 no 1220 0.404787970539774 1902 19154699
SGTC_2014 4013930 200 µM 0.239941054637906 0.376665011664728 no 1221 0.405187976665539 2029 64556
SGTC_777 1315-0167 517 µM 0.239349079477153 0.376886585786416 no 1222 0.405417455603057 1823 4221767
SGTC_2368 9071271 200 µM 0.239333007489938 0.376892602037799 no 1223 0.4054236863563 1815 27209959
SGTC_410 α-linolenic acid 100 µM 0.237889452339298 0.377433091981304 no 1224 0.405983418262382 1960 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1832 st054113 55 µM 0.236145152705179 0.378086505760919 no 1225 0.406660018863348 2016 1251267
SGTC_574 1315-0397 40 µM 0.235683696352589 0.378259425515344 no 1226 0.406839060990034 1939 6794277
SGTC_1060 3448-7350 82 µM 0.235309762115246 0.378399566334948 no 1227 0.406984159378364 1993 570178
SGTC_1885 st057546 99.9 µM 0.23497008094199 0.37852688386351 no 1228 0.407115977554942 1974 702008
SGTC_1666 st014829 29 µM 0.234898089622642 0.378553868968962 no 1229 0.407143916176072 1863 3858230
SGTC_166 k072-0058 166.424 µM 0.23443259544798 0.378728368313891 no 1230 0.407324578040048 2036 5846229
SGTC_44 0929-0055 61.211 µM 0.234133836004528 0.378840377003078 no 1231 0.407440539264507 1855 1379590
SGTC_689 0833-0039 98 µM 0.233860702434103 0.378942787133577 no 1232 0.407546561097798 1985 5374726
SGTC_2716 st080858 38.6235 µM 0.23224929515133 0.379547149369414 no 1233 0.408172196147319 1984 5296050
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.230986926889011 0.380020809416299 no 1234 0.408662479129131 1946 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_812 4251-0442 148 µM 0.230323565196828 0.380269785158957 no 1235 0.40892017520972 2025 5723007
SGTC_1780 st038448 24.544 µM 0.228869642330915 0.38081565111308 no 1236 0.409485118124491 1969 728868 YDL195W SEC31
SGTC_969 1313-0238 134 µM 0.228074587772674 0.381114249655417 no 1237 0.409794127750075 1885 5212874
SGTC_164 4100-3994 89.624 µM 0.227934682062106 0.381166801356423 no 1238 0.409848509961745 2041 4615967
SGTC_83 0170-0301 39.027 µM 0.227471995613416 0.38134061229536 no 1239 0.410028371380956 2010 3089716
SGTC_92 0063-0024 660.874 µM 0.226686670942894 0.381635678991859 no 1240 0.410333696189475 2030 3594437
SGTC_1313 1220-0047 237 µM 0.223898321313807 0.382683888404619 no 1241 0.411418210986072 1952 3528706
SGTC_1525 8-methoxypsoralen 92.5 µM 0.221009563720996 0.383770750651968 no 1242 0.412542493165229 2053 4114 Related to psoralen; DNA damaging agent.
SGTC_2466 5983409 37.09 µM 0.220348856173801 0.384019463241225 no 1243 0.412799736662012 1899 2879657
SGTC_307 1501-1223 22.3 µM 0.21916572003636 0.384464954868786 no 1244 0.413260478883419 1931 2830329
SGTC_2902 5787006 60.46 µM 0.217677644417584 0.385025483401769 no 1245 0.41384014159143 1882 591003
SGTC_2928 9011484 9.79 µM 0.217438477172199 0.385115595402438 no 1246 0.413933323984502 1903 2994751
SGTC_2602 kawain 100 µM 0.21705107027477 0.385261573412906 no 1247 0.414084272582795 2044 5369129
SGTC_2044 5102272 200 µM 0.217013154583764 0.385275861221702 no 1248 0.414099046673741 1929 592666
SGTC_2595 hexamethylquercetagetin 100 µM 0.217009227637228 0.3852773410259 no 1249 0.414100576840465 1925 386331
SGTC_1447 4239-0816 81.9 µM 0.216574522612901 0.385441162674717 no 1250 0.414269971252829 1852 1341554
SGTC_1835 st008666 49.2 µM 0.214643183432663 0.386169248225037 no 1251 0.415022761510627 1870 690455
SGTC_148 3253-0744 288.01 µM 0.214132338447055 0.38636189620408 no 1252 0.415221929092361 2026 6893655
SGTC_1785 bathophenanthroline 24 µM 0.214091910463542 0.386377143453212 no 1253 0.415237692033259 1859 72812 An iron chelator.
SGTC_3170 9103054 49.47 µM 0.211729043418928 0.387268593172556 no 1254 0.416159214188325 1916 16432970
SGTC_925 2064-1272 59.6 µM 0.211069289292857 0.387517608077497 no 1255 0.416416601982679 1862 6815817
SGTC_2188 6126565 140.678 µM 0.210916889521153 0.387575135809145 no 1256 0.416476062324674 2018 874518
SGTC_1386 3228-0095 33.8 µM 0.210781260264893 0.387626335097283 no 1257 0.416528981084613 2010 870181
SGTC_1523 st012844 44.7 µM 0.210647871011858 0.387676690702704 no 1258 0.416581027333256 1929 4274103
SGTC_3073 9114972 49.47 µM 0.209957639496644 0.387937289279662 no 1259 0.416850367433444 2066 41905075
SGTC_2198 6589944 200 µM 0.209934811630389 0.387945908858691 no 1260 0.416859275923419 1978 5290268
SGTC_1211 1056-0033 32.3 µM 0.209824912566632 0.387987406442916 no 1261 0.416902164222086 2055 6741922
SGTC_1222 0366-0074 1.18 µM 0.208885621703538 0.38834213222987 no 1262 0.417268764395084 2042 286520
SGTC_1651 st011928 86.1 µM 0.207398498176003 0.388903938931329 no 1263 0.417849327692539 1979 720198
SGTC_479 n-linoleoylglycine 10 µM 0.205076004948167 0.389781796749554 no 1264 0.418756371641666 1925 6433346 An anti-infammatory.
SGTC_399 oxolinic acid 75 µM 0.20505533604412 0.389789611730224 no 1265 0.418764445777558 1923 4628 A DNA gyrase inhibitor.
SGTC_2136 5328288 199.296 µM 0.205051417939729 0.389791093183418 no 1266 0.418765976356391 1917 262395
SGTC_1271 0832-2808 169 µM 0.20368363352616 0.39030835642274 no 1267 0.419300366320685 2056 3663794
SGTC_3072 9116419 49.47 µM 0.20296242694394 0.390581177715649 no 1268 0.41958219995194 1935 17170162
SGTC_128 0906-2981 13.371 µM 0.202377349846776 0.390802542921245 no 1269 0.419810867121857 2052 6740226
SGTC_2201 6605497 169.863 µM 0.201644399964226 0.391079906051861 no 1270 0.420097365986997 2030 670741
SGTC_2162 5663267 200 µM 0.201481663627577 0.391141496310447 no 1271 0.420160982874533 2042 6456493
SGTC_1900 st060200 72.8 µM 0.200480599853673 0.3915204254494 no 1272 0.420552364538494 1909 688945
SGTC_22 0964-0034 14.468 µM 0.200306015467292 0.391586520815182 no 1273 0.420620629111899 1951 138402
SGTC_834 0312-0008 75.7 µM 0.200113639279428 0.391659355548829 no 1274 0.420695853256008 1941 6385573 YIL048W NEO1
SGTC_3329 9141233 27.5565 µM 0.200087333597143 0.391669315326999 no 1275 0.420706139694092 2035 4909101 YNL103W MET4
SGTC_1334 1486-0610 236 µM 0.19929814967919 0.3919681467555 no 1276 0.421014763242004 1993 3742339
SGTC_191 3914-0123 66.505 µM 0.198598760134688 0.392233030034959 no 1277 0.421288311780741 1932 3144412
SGTC_218 alverine citrate 93.75 µM 0.19736992700405 0.392698553012636 no 1278 0.421769030747185 2041 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_662 k832-1615 104 µM 0.197188182573573 0.392767416914714 no 1279 0.421840139001521 1983 5878478
SGTC_2235 salicylic acid 500 µM 0.197087819156277 0.392805446569966 no 1280 0.421879407692808 2064 338 A COX inhibitor and kinase inhibitor.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.196342628933419 0.393087845654838 no 1281 0.422170998805913 2039 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_328 k915-0120 63.5 µM 0.196225191601005 0.393132355126245 no 1282 0.422216955642903 2058 6624543
SGTC_1798 st045719 60.953 µM 0.196108988178994 0.393176398313116 no 1283 0.422262430655253 2041 3980186
SGTC_1414 3917-0015 5.4 µM 0.195577942688018 0.393377691498961 no 1284 0.422470263019156 2029 6618702
SGTC_2805 7950783 58.44 µM 0.194313798981986 0.393856980700006 no 1285 0.422965090766175 1977 1178958 YDL195W SEC31
SGTC_403 arphamenine a 50 µM 0.193959906060128 0.39399118499877 no 1286 0.42310363799776 1980 5487158 An arginine aminopeptidase inhibitor.
SGTC_252 miconazole 1.30953 nM 0.193038872326193 0.394340521060625 no 1287 0.423464262439439 2035 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1423 4048-0112 5.59 µM 0.192861293712077 0.394407884091964 no 1288 0.423533799510405 2063 X1423
SGTC_3288 9119690 36.221 µM 0.191723905298503 0.394839418127599 no 1289 0.423979239814784 1907 17595618 YKL019W RAM2
SGTC_716 1683-5115 658 µM 0.191439338968254 0.394947405015704 no 1290 0.424090700962335 2088 723597
SGTC_3258 9138477 49.47 µM 0.191096902054079 0.395077363261605 no 1291 0.424224837358444 1986 4970355
SGTC_2658 polymyxin b sulfate 77.05 µM 0.19087836210174 0.395160307469642 no 1292 0.424310446508715 1974 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2665 lovastatin 100 µM 0.190101661903148 0.395455133099964 no 1293 0.424614733909266 1971 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_502 l-744,832 89.3 µM 0.18749109548107 0.396446508973448 no 1294 0.425637802337391 2077 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_432 NS 1619 61.3 µM 0.186148740251154 0.39695653640107 no 1295 0.426164060311645 1965 4552 A K+/calcium channel activator.
SGTC_186 3455-3465 67.277 µM 0.185413498399867 0.397235966084415 no 1296 0.426452360894794 2016 755278
SGTC_593 1203-0218 61.7 µM 0.185238728183241 0.397302395512948 no 1297 0.426520896996915 2088 3666956
SGTC_1033 k072-0102 21.3 µM 0.184389233360616 0.397625327340768 no 1298 0.426854057771653 2090 5965931
SGTC_1196 1588-0294 184 µM 0.18430696141791 0.397656606398802 no 1299 0.426886326528787 1951 6144269
SGTC_63 0099-0242 26.702 µM 0.184031560178782 0.397761316277664 no 1300 0.426994348148659 2100 3898502 YLR359W ADE13
SGTC_544 k015-0020 52.4 µM 0.183632638708829 0.3979130026526 no 1301 0.427150828260396 1961 3008304
SGTC_2583 asiatic acid 100 µM 0.182572800452416 0.398316071721887 no 1302 0.427566613845007 2011 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1079 idarubicin 2.36 µM 0.182047349525578 0.398515947211091 no 1303 0.427772783578011 2114 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_201 4262-0159 12.803 µM 0.181780080276238 0.398617623578244 no 1304 0.427877658847968 2084 1341029
SGTC_2308 7584454 197.62 µM 0.18043377641854 0.399129898062717 no 1305 0.428406019850709 2068 893577
SGTC_3157 9099274 49.47 µM 0.180317374327945 0.399174197739384 no 1306 0.428451708243918 2094 17217662
SGTC_2752 diclazuril 33.15 µM 0.178396044539521 0.39990559421169 no 1307 0.429205977740556 2102 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_933 2914-0560 114 µM 0.177810333848523 0.400128627864573 no 1308 0.429435965720456 2135 463887
SGTC_454 lyso-paf C-16 6.67 µM 0.175450152878799 0.401027694150925 no 1309 0.430362967696914 1923 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2651 TUB2.036 5 µM 0.174072578184534 0.40155269784853 no 1310 0.430904211801354 2098 15992207 YFL037W TUB2
SGTC_535 2293-4129 48.2 µM 0.173962746952033 0.401594562990258 no 1311 0.43094736969477 2099 396118 YIL048W NEO1
SGTC_3142 9086498 49.47 µM 0.173107935692158 0.401920435966262 no 1312 0.431283293671895 2126 25236367
SGTC_207 4185-0010 4.486 µM 0.170860793042122 0.402777421229786 no 1313 0.432166612939444 2097 3761753
SGTC_1478 0453-0656 35.7 µM 0.170200532136442 0.403029311731626 no 1314 0.43242621662045 2077 5258496
SGTC_197 4544-0043 41.561 µM 0.169609824124618 0.403254701817561 no 1315 0.43265849798275 2109 896523
SGTC_3236 9132701 49.47 µM 0.169145741806245 0.403431799253243 no 1316 0.432841003241591 1984 24282524
SGTC_2560 caryophyllene 100 µM 0.166938788605394 0.404274260262892 no 1317 0.433709106239925 2119 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3021 9087658 49.47 µM 0.166481309437397 0.404448949643088 no 1318 0.433889095410812 2126 25237042
SGTC_389 tpck 16.7 µM 0.165950394435067 0.404651704531884 no 1319 0.434097994130172 1994 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2241 6772625 37.8075 µM 0.165774959690219 0.404718708179608 no 1320 0.434167026353564 2167 2285411
SGTC_936 3005-4620 401 µM 0.165640320522739 0.404770132701096 no 1321 0.434220007192656 2128 777207
SGTC_967 1306-0166 352 µM 0.16425674120073 0.40529867663023 no 1322 0.434764517304006 2113 4437607
SGTC_788 1182-0090 188 µM 0.163792222560031 0.405476167118204 no 1323 0.434947357245019 2111 5715185
SGTC_429 1112-0049 25.5 µM 0.161746045658127 0.406258233058972 no 1324 0.435752921368538 1920 2836170
SGTC_3209 9113616 49.47 µM 0.160677981177986 0.406666605066603 no 1325 0.436173516276346 2183 16649353
SGTC_2185 6113692 200 µM 0.160239549720982 0.406834267744986 no 1326 0.43634618786147 2014 874150
SGTC_2927 9011802 47.9 µM 0.157711594970917 0.407801327249618 no 1327 0.437342031689932 1958 43912568
SGTC_2644 guaiazulene 100 µM 0.155771297793853 0.408543962146287 no 1328 0.438106647728652 2123 3515 A coloring agent.
SGTC_47 0149-0135 24.25 µM 0.155637056510305 0.408595354221092 no 1329 0.438159556988871 2070 5239155
SGTC_864 0469-0573 172 µM 0.155411528493484 0.408681697463459 no 1330 0.43824844808276 1942 689425
SGTC_507 nimesulide 162 µM 0.155400618569326 0.408685874432666 no 1331 0.438252748270969 2131 4495 A COX2 inhibitor.
SGTC_1147 3809-1045 12.3 µM 0.152114630127897 0.409944416597808 no 1332 0.43954826265767 1993 325925
SGTC_367 0335-0881 7.1 µM 0.150848130993451 0.410429737639262 no 1333 0.440047758804092 2090 23828853
SGTC_3124 9127567 49.47 µM 0.150343027574234 0.410623331011094 no 1334 0.440246993825702 2143 17592030
SGTC_1794 st048918 76.9 µM 0.15032682925217 0.410629539779087 no 1335 0.440253383407577 2139 672303
SGTC_322 k048-0136 19.3 µM 0.150046733196089 0.410736903293028 no 1336 0.440363872414455 2071 6823282
SGTC_1675 st018485 24.5 µM 0.15003097719623 0.410742942918183 no 1337 0.440370087794507 1993 3323024
SGTC_396 dithiazanine 1.25 µM 0.149565338946226 0.410921441963433 no 1338 0.440553778015825 1982 10578 An antihelmenthic.
SGTC_1183 1254-0324 198 µM 0.14862168611291 0.411283240968897 no 1339 0.440926080007294 2097 5799357
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.148507524217137 0.411327016066421 no 1340 0.440971124166516 2162 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1625 st003711 30.1 µM 0.146194243388766 0.412214275003335 no 1341 0.441884024923787 2104 24207034 YER133W GLC7
SGTC_1699 st031318 29.054 µM 0.145625234182177 0.412432587463238 no 1342 0.442108623171834 2118 5340658
SGTC_474 dl-dihydrosphingosine 5 µM 0.145477647761455 0.412489216554247 no 1343 0.442166881249915 2119 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_563 tetrahydrosecaminediol 614 µM 0.145234020104535 0.412582700770743 no 1344 0.442263053260847 2143 334274 A psychoactive constituent of the cannabis plant.
SGTC_2860 9025725 38.96 µM 0.144624133885019 0.412816746573169 no 1345 0.442503820739125 1956 40546248
SGTC_1232 0279-0259 161 µM 0.142246277678457 0.413729551828721 no 1346 0.443442739551917 2007 1560000
SGTC_2976 9009005 19.48 µM 0.141559278831042 0.413993362211975 no 1347 0.443714066857774 2166 2993148
SGTC_2472 5377652 49.4 µM 0.140116428521489 0.414547548898787 no 1348 0.44428400027896 2006 1610903
SGTC_2873 9040596 71.43 µM 0.139521343078499 0.414776165840477 no 1349 0.444519095772904 1983 6463863
SGTC_1636 st007707 68.9 µM 0.138460164072347 0.415183915860682 no 1350 0.444938375391546 2130 403051
SGTC_2314 7727897 200 µM 0.138196581595392 0.415285209620365 no 1351 0.445042528333972 2049 900724
SGTC_3039 9090270 49.47 µM 0.137874504155397 0.415408990418759 no 1352 0.445169800339319 2183 17173750
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.136854435957701 0.415801078363036 no 1353 0.445572927355925 2162 165521
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.136671203125977 0.415871517237666 no 1354 0.445645346238879 2156 688798
SGTC_2639 lactacystin 53 µM 0.136667565213222 0.415872915761573 no 1355 0.445646784064957 2139 3870 A proteasome inhibitor.
SGTC_1941 st076221 61.8 µM 0.136295692289 0.41601588060074 no 1356 0.445793764581579 2190 2828568
SGTC_2816 7982706 58.44 µM 0.133851624283048 0.416955767049355 no 1357 0.446759952088037 2046 2981853
SGTC_1527 coumarin 137 µM 0.132910451942399 0.417317829540571 no 1358 0.447132100394821 2107 323 A hepatotoxic, DNA x-linker.
SGTC_1321 1326-2144 215 µM 0.132610508697454 0.417433230381484 no 1359 0.447250710544714 2170 3513030
SGTC_2686 alizarin 95.37 µM 0.130101876148475 0.418398684897098 no 1360 0.448242912893309 2050 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2114 5491910 81.25 µM 0.129631599853659 0.418579727009247 no 1361 0.448428950558866 2145 2849228
SGTC_3028 9087778 49.47 µM 0.129517937317412 0.418623486228357 no 1362 0.448473916282652 2137 17217395
SGTC_2702 st077768 96.8 µM 0.129056587784529 0.418801112652102 no 1363 0.448656436294591 2057 6484119
SGTC_224 benfluorex 43.875 µM 0.128755602849375 0.418917005249222 no 1364 0.448775518408328 2179 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_587 k089-0003 57 µM 0.128363303420808 0.419068068552035 no 1365 0.448930735245777 2194 9659696
SGTC_2506 ethyl hematommate 54.16 µM 0.128356021175192 0.419070872849657 no 1366 0.448933616606466 1993 3940691 An allergen.
SGTC_3263 9137018 49.47 µM 0.128257478969672 0.419108820569442 no 1367 0.448972606992125 1989 43844957
SGTC_3352 9151559 45.5865 µM 0.125369009290885 0.420221477217266 no 1368 0.450115710757758 2083 17159339
SGTC_1623 st003709 20.3 µM 0.121061144672137 0.42188207621633 no 1369 0.451821302410512 2037 16192618
SGTC_2851 9015922 71.43 µM 0.120536996557472 0.422084220675431 no 1370 0.452028887132222 2151 2996893
SGTC_2617 dihydrotanshinone i 20.83 µM 0.120409745796973 0.422133299666048 no 1371 0.452079285771758 2123 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2612 dictamnine 15.46 µM 0.119826118766299 0.422358412626001 no 1372 0.452310445613467 2083 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_203 k066-0004 30.888 µM 0.1194134857828 0.422517586144076 no 1373 0.452473888816727 2207 6795412
SGTC_3044 9093193 49.47 µM 0.118466763365493 0.422882832886246 no 1374 0.452848914302467 2058 25236277
SGTC_2221 6807166 181.081 µM 0.117702941898926 0.4231775645438 no 1375 0.453151517844305 2192 674925
SGTC_1174 0739-0097 51.1 µM 0.117657099426818 0.423195254899893 no 1376 0.453169680147137 2095 728447
SGTC_3314 9135860 59.4275 µM 0.116785199798363 0.423531745577687 no 1377 0.453515136169752 2192 25252478
SGTC_553 k007-0256 45.7 µM 0.116657571225445 0.423581005732014 no 1378 0.453565706942551 2088 6287000
SGTC_1886 st057356 49.9 µM 0.114785549160181 0.424303677457861 no 1379 0.454307551720358 2015 24207747
SGTC_2268 7933382 153.85 µM 0.114093766314179 0.424570796499237 no 1380 0.45458173185868 2210 935025 YOR257W CDC31
SGTC_3031 9088762 49.47 µM 0.113631947483555 0.424749138517925 no 1381 0.45476478047044 2207 205253
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.113572729008229 0.424772008216366 no 1382 0.454788253270286 2211 1273210
SGTC_2316 5844804 197.44 µM 0.11349866884294 0.42480061001235 no 1383 0.454817609186379 2210 776813
SGTC_455 paf C-16 10 µM 0.112286144370312 0.425268939231375 no 1384 0.455298263757521 2165 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2918 7977171 22.06 µM 0.111751617370959 0.42547543013639 no 1385 0.455510175437222 2184 2236483
SGTC_2999 9069765 71.4286 µM 0.110851940579295 0.425823026672978 no 1386 0.455866878246807 2151 2097066
SGTC_1040 k898-0338 155 µM 0.109375840477911 0.426393453224117 no 1387 0.456452197637295 2242 20969351
SGTC_2721 ifenprodil 61.44 µM 0.108531946744207 0.426719638178878 no 1388 0.456786870170438 2200 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3269 9137823 49.47 µM 0.106832238989657 0.427376767482509 no 1389 0.457461035405963 2071 17682936
SGTC_1914 st062367 72.6 µM 0.106019484434022 0.427691060390502 no 1390 0.45778344648424 2144 978205
SGTC_3328 9140624 29.0385 µM 0.105985103859429 0.42770435640224 no 1391 0.457797085506068 2209 4904392
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.105827420969147 0.427765338213551 no 1392 0.457859640081979 2206 94937 An inhibitor of serotonin biosynthesis.
SGTC_2767 sibutramine 71.45 µM 0.105773892682059 0.427786039976243 no 1393 0.457880875592861 2205 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2944 9067346 25.62 µM 0.105404693206281 0.427928831199363 no 1394 0.458027346085763 2149 6473075
SGTC_2086 5274770 176.623 µM 0.104590484027009 0.428243767269198 no 1395 0.458350382967824 2124 689278
SGTC_418 lividomycin a 100 µM 0.104562445953115 0.42825461321004 no 1396 0.458361507543843 2242 72394 An antibiotic.
SGTC_104 0074-0074 590.992 µM 0.103590067923964 0.428630790733346 no 1397 0.45874733495261 2245 3943124
SGTC_2247 cerulenin 830 nM 0.0997198564048211 0.430128673561215 no 1398 0.460283367992947 2202 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2715 st079500 56.4 µM 0.0990440598437598 0.430390329994574 no 1399 0.460551643683197 2194 28246688
SGTC_1558 st069300 45.6 µM 0.0973490982484236 0.43104672326791 no 1400 0.461224583180842 2245 24208000
SGTC_786 4544-0069 423 µM 0.0970636594411399 0.431157281503721 no 1401 0.461337920057633 2156 748821 YLR208W SEC13
SGTC_99 0109-0120 622.8 µM 0.096880507184582 0.431228224210117 no 1402 0.46141064449609 2219 759414
SGTC_2266 7929956 200 µM 0.0966482733785259 0.431318181490911 no 1403 0.461502859646654 2250 2967153
SGTC_175 3793-3120 23.7 µM 0.0964213814427985 0.431406073004076 no 1404 0.461592955652039 2150 5322297
SGTC_855 0428-0020 25 µM 0.0951624980087304 0.431893790393467 no 1405 0.462092878507351 2111 6812414
SGTC_1285 0929-0069 65.5 µM 0.0945972441559078 0.432112815206469 no 1406 0.462317369432958 2144 1206237
SGTC_3151 9099821 49.47 µM 0.0924749078269727 0.432935364744378 no 1407 0.463160363217386 2165 17174189
SGTC_757 1066-0008 322 µM 0.0922741046526425 0.433013204725462 no 1408 0.463240131035117 2205 6842497
SGTC_2775 cyproheptadine 69.59 µM 0.0911189530836436 0.433461041744335 no 1409 0.463699036453141 2257 2913 A selective serotonin reuptake inhibitor.
SGTC_425 3825-7017 13.1 µM 0.090137522668311 0.433841596525905 no 1410 0.464088965894513 2182 3397440
SGTC_3126 9127922 49.47 µM 0.0900486388752084 0.433876064716104 no 1411 0.46412428178104 2176 45595682
SGTC_2894 9048625 32.47 µM 0.0895579512742839 0.434066357195016 no 1412 0.46431925004874 2244 4092861
SGTC_352 k048-0007 5.11 µM 0.0891311860270159 0.434231872512521 no 1413 0.464488826577687 2233 6811911
SGTC_1037 k284-1091 78.7 µM 0.0891255280667869 0.434234066955878 no 1414 0.464491074829581 2241 3334711
SGTC_2626 ethyl orsellinate 100 µM 0.0884667436273849 0.434489590744056 no 1415 0.464752857707616 2208 75653 A natural product.
SGTC_1978 st071761 42 µM 0.0878433402182587 0.434731416440912 no 1416 0.465000595186085 2081 5147680
SGTC_1856 st057054 55.7 µM 0.0868703024621178 0.435108918287115 no 1417 0.46538730272959 2244 1266018
SGTC_2274 7947094 46.08 µM 0.0867999851882546 0.435136201025743 no 1418 0.465415249699441 2273 2971028
SGTC_2372 9071633 200 µM 0.0862240075222031 0.435359688994344 no 1419 0.465644173265701 2280 21321366
SGTC_958 1222-0007 33 µM 0.0847413542925419 0.435935075492884 no 1420 0.466233509110463 2223 7312461
SGTC_151 3013-0144 2.285 µM 0.0845302188815037 0.436017023760086 no 1421 0.466317438810396 2265 906558 YHR107C CDC12
SGTC_1932 st074806 40.9 µM 0.0826842952516786 0.436733601159271 no 1422 0.467051286340715 2192 17251235
SGTC_945 3381-0768 11.3 µM 0.082357257615918 0.436860577090631 no 1423 0.467181312009277 2261 1126236 YIL048W NEO1
SGTC_2797 7859098 81.82 µM 0.081547913929708 0.437174841552448 no 1424 0.467503110962546 2214 972681
SGTC_1733 st037357 54.9 µM 0.0814755033407354 0.437202960188944 no 1425 0.467531902800208 2267 1272339 YGL099W LSG1
SGTC_102 gallobenzophenone 83.616 µM 0.0802705769118822 0.437670906274494 no 1426 0.468011029452164 2271 70837
SGTC_354 2783-3500 4.88 µM 0.0797167223979765 0.437886030896391 no 1427 0.468231279614988 2157 6740761
SGTC_2269 7935389 174.42 µM 0.079621476178016 0.437923027674783 no 1428 0.468269156961328 2262 97605
SGTC_95 0471-0001 561.058 µM 0.0786355251066695 0.438306035466448 no 1429 0.468661265033743 2103 4015405
SGTC_2010 4012422 159 µM 0.0785108497888434 0.438354471626268 no 1430 0.46871084999037 2218 952393
SGTC_2364 9055074 200 µM 0.0784422322811526 0.438381129811304 no 1431 0.468738140251385 2175 6470630
SGTC_908 3448-7491 47.7 µM 0.0781924016156217 0.438478192417574 no 1432 0.468837503072797 2217 1203031
SGTC_1661 st013063 9.66 µM 0.0778506407261265 0.438610977156762 no 1433 0.468973431587736 2259 721395
SGTC_1990 st072050 59.8 µM 0.0777474049913592 0.438651088811457 no 1434 0.469014492235299 2255 17233948
SGTC_154 3389-1638 511.116 µM 0.0770483039646054 0.438922737081246 no 1435 0.469292559069283 2023 5238686
SGTC_171 k064-0041 9.68 µM 0.0763834783998726 0.4391810936959 no 1436 0.469557006764497 2163 53325
SGTC_581 0958-0271 211 µM 0.0760922003530057 0.439294294880235 no 1437 0.469672872684172 2243 4591145
SGTC_1102 cgs 12066b 26.1 µM 0.0753159380954311 0.439596002691193 no 1438 0.469981670366485 2183 6438352 A 5-HT1B full agonist.
SGTC_2581 avocatin a 64 µM 0.0746402976139258 0.439858630667258 no 1439 0.470250455336317 2209 6710728 A skin care supplement.
SGTC_1583 clindamycin 39.6 µM 0.0725602647395768 0.440667325192097 no 1440 0.471078023737894 2109 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_106 0092-0003 11.579 µM 0.0719222414087007 0.440915431597915 no 1441 0.471331894899878 2284 1072148
SGTC_2058 5236698 133 µM 0.0707062722929851 0.441388346359966 no 1442 0.471815764383217 2233 766665
SGTC_1557 sumaresinolic acid 42.3 µM 0.0702460738664488 0.441567348589705 no 1443 0.471998901614776 2265 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1844 rapamycin 4 nM 0.0702150175287496 0.44157942892593 no 1444 0.472011260783597 2182 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_511 blebbistatin 171 µM 0.0699098223557823 0.441698147046321 no 1445 0.472132717575205 2282 3476986 A myosin inhibitor.
SGTC_2450 5739737 12.93 µM 0.0696390982360487 0.441803460627539 no 1446 0.472240458286598 2201 2262825
SGTC_62 0180-0423 3.232 µM 0.0691596587318886 0.441989976046632 no 1447 0.472431266926852 2231 30102 YGL099W LSG1
SGTC_1082 camptothecin 424.86 nM 0.0689980426563665 0.442052852135216 no 1448 0.47249558876099 2294 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2260 7964312 200 µM 0.0679403310879505 0.442464386568336 no 1449 0.472916566670667 2281 231951
SGTC_2795 7780010 54.55 µM 0.0679234632837004 0.442470949998058 no 1450 0.472923280441911 2224 953673
SGTC_108 0509-0257 621.132 µM 0.0671175124897305 0.442784571804894 no 1451 0.473244076190279 2266 536624
SGTC_955 1216-0110 33 µM 0.0666518092462941 0.442965808521712 no 1452 0.473429449798679 2251 3619719
SGTC_1927 st060202 13.8 µM 0.0662323053437025 0.443129076159778 no 1453 0.473596438643854 2309 688887
SGTC_835 0312-0010 67.2 µM 0.066017452642107 0.443212698891958 no 1454 0.473681965283271 2277 1626196
SGTC_331 k048-0133 24.5 µM 0.0654562547068719 0.443431134433075 no 1455 0.473905367644433 2287 6813582
SGTC_113 0099-0221 2.5 µM 0.0651174804022202 0.443563004163828 no 1456 0.474040231311172 2283 89219
SGTC_2348 9022543 33.42 µM 0.0649544421854966 0.443626469900311 no 1457 0.47410513673935 2237 3162678 YDL140C RPO21
SGTC_1067 clotrimazole 1.36 µM 0.0646817963742076 0.443732605714288 no 1458 0.474213678428145 2217 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2077 5212015 200 µM 0.0627755372514854 0.444474788374985 no 1459 0.474972622942077 2303 780900
SGTC_101 0490-5701 117.494 µM 0.0624706421692171 0.444593514314931 no 1460 0.475094020208604 2290 4661669
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.061046325256431 0.445148208047851 no 1461 0.475661157803328 2272 688751
SGTC_818 4072-2707 53.5 µM 0.0610379555461603 0.445151467911894 no 1462 0.475664490619567 2287 882871
SGTC_1696 st025591 34.7925 µM 0.0587691005733587 0.446035285539761 no 1463 0.476568010038389 2321 2787147
SGTC_433 pimozide 108 µM 0.0571227301622038 0.446676786548487 no 1464 0.477223714966311 2306 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1913 st060213 96.1 µM 0.0569858757349358 0.446730117581574 no 1465 0.477278223193915 2298 688959
SGTC_2862 9027634 71.43 µM 0.0564204339383035 0.446950475754191 no 1466 0.477503439476441 2286 5012562
SGTC_264 promethazine 12.5 mM 0.0563717891931399 0.446969433851059 no 1467 0.477522815085222 2311 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1139 k015-0024 46.9 µM 0.0559326768323935 0.447140572607629 no 1468 0.477697719609504 2300 2766652
SGTC_944 3370-0224 231 µM 0.054871917768704 0.447554031231226 no 1469 0.478120252267749 2277 4580514
SGTC_1075 aripiprazole 15.2 µM 0.0542991531624737 0.447777304960606 no 1470 0.478348412119112 2286 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2807 7945238 51.95 µM 0.0524059951765264 0.448515408636534 no 1471 0.479102598611645 2276 17148797
SGTC_2382 9035899 200 µM 0.0502653448902861 0.449350219112971 no 1472 0.479955469807535 2319 6462679
SGTC_630 4356-0227 183 µM 0.0493578742987721 0.449704182253318 no 1473 0.480317049329041 2315 779312
SGTC_760 0568-0725 82.9 µM 0.0492205402415286 0.449757753537044 no 1474 0.480371771179242 2326 3916171
SGTC_642 0335-0876 158 µM 0.0477394400818159 0.450335559232776 no 1475 0.480961950640723 2289 6812350
SGTC_1462 k081-0014 26.5 µM 0.0473398561353741 0.450491462710557 no 1476 0.481121181536413 2309 3270634
SGTC_497 capsazepine 133 µM 0.0464431473596421 0.450841354430491 no 1477 0.481478523488209 2310 2733484 A calcium channel blocker.
SGTC_2887 9044784 58.44 µM 0.0457210624108425 0.451123136502366 no 1478 0.481766287993163 2331 6465546
SGTC_728 3030-5151 22.5 µM 0.0456579186741388 0.45114777850628 no 1479 0.481791452420017 2311 3125388
SGTC_2137 5261020 140 µM 0.0451158912309754 0.451359313829812 no 1480 0.482007467474581 2328 763655
SGTC_1058 3448-5425 97.3 µM 0.0447273867734823 0.451510942728959 no 1481 0.482162302024514 2320 7279705
SGTC_1700 st030840 7.9285 µM 0.044624027414154 0.451551283911165 no 1482 0.482203495313258 2322 5499307
SGTC_1899 st063254 59.6 µM 0.0441456780209251 0.451737990301052 no 1483 0.482394141229017 2312 3093813
SGTC_2407 paclitaxel 400 µM 0.0435884974325976 0.451955479054139 no 1484 0.482616210351646 2222 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2688 kanamycin b 96.69 µM 0.0420411321790569 0.452559549928675 no 1485 0.48323295417477 2290 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1277 0873-0036 22 µM 0.0419592422181098 0.452591521755477 no 1486 0.483265594740588 2310 5965735
SGTC_2883 9059145 45.46 µM 0.039885370474006 0.453401313490661 no 1487 0.484092257246507 2326 16476510
SGTC_934 2950-0684 338 µM 0.0394796776743543 0.453559748503772 no 1488 0.484253977874937 2332 1121253
SGTC_2975 9084847 53.72 µM 0.0391437605269625 0.453690939660164 no 1489 0.484387885915631 2197 27211724
SGTC_2966 9084041 48.03 µM 0.0390310530077135 0.453734958283411 no 1490 0.484432815375058 2332 17741380
SGTC_2325 6158266 200 µM 0.0384810806337425 0.453949761560955 no 1491 0.484652057888768 2285 3623240
SGTC_1436 4092-1007 8.32 µM 0.0384242654910918 0.453971952678587 no 1492 0.48467470710049 2330 2881121
SGTC_599 1935-0052 86.5 µM 0.0374924807167588 0.454335913879409 no 1493 0.485046167726051 2335 9557311
SGTC_2488 5268135 45.7 µM 0.0354411933283169 0.455137294793176 no 1494 0.485863968902098 2305 1270356 YLR208W SEC13
SGTC_1530 rhein 70.4 µM 0.0344997045282393 0.455505169609439 no 1495 0.486239338980834 2345 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_996 3970-0799 1.8 µM 0.0342233908296385 0.455613142941351 no 1496 0.486349507139656 2299 6615648 YGL040C HEM2
SGTC_2630 antimycin a 100 µM 0.0333325038785956 0.455961291407784 no 1497 0.486704716903692 2340 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_326 k292-0812 17.5 µM 0.0332223985698453 0.456004321660841 no 1498 0.486748618251967 2347 3579357
SGTC_500 h-89 112 µM 0.0317857172729016 0.456565838155313 no 1499 0.487321468423546 2341 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1545 lovastatin 49.4 µM 0.0312561712842336 0.456772829313615 no 1500 0.487532621781503 2334 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2697 mebhydrolin 72.4 µM 0.0304322490530654 0.457094910794837 no 1501 0.48786116286752 2338 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_415 dibenzyl ketone 100 µM 0.0299778587462317 0.457272549707391 no 1502 0.488042355697095 2341 7593
SGTC_1895 st058434 18.3 µM 0.0298041345023484 0.457340467555227 no 1503 0.488111630688489 2361 5393175
SGTC_1951 sophoraflavanone G 9.2 µM 0.0292531332901915 0.457555890837364 no 1504 0.488331352552743 2356 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2347 9049783 174.81 µM 0.0286915683632049 0.457775457014612 no 1505 0.488555290536193 2325 6467988 YPL169C MEX67
SGTC_2694 st077685 81.9 µM 0.0277792118511918 0.458132206582456 no 1506 0.488919123051693 2342 2838096
SGTC_3198 9112019 49.47 µM 0.0272252223731412 0.458348843979684 no 1507 0.489140049307549 2352 45595555
SGTC_308 4092-1169 104 µM 0.026843004227988 0.458498317472374 no 1508 0.489292476574659 2347 2268590 YDL196W YDL196W
SGTC_2746 daunorubicin 9.88 µM 0.0266440454464258 0.458576126316784 no 1509 0.489371821265176 2362 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_189 3970-0742 2.116 µM 0.0258200436017481 0.458898394006892 no 1510 0.489700437347725 2365 2891807
SGTC_617 3770-0098 35 µM 0.0249069235409931 0.459255547438649 no 1511 0.490064602380725 2327 5962639
SGTC_1426 4048-4480 71.7 µM 0.023645893839108 0.459748834600797 no 1512 0.490567532191161 2364 14224343
SGTC_260 nsc-65238 3.989 µM 0.0236195657983629 0.459759134215926 no 1513 0.490578032627086 2353 3246252
SGTC_117 lucigenin 22.078 µM 0.023619555094701 0.459759138403239 no 1514 0.490578036896039 2317 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1097 itavastatin 7.23 µM 0.0232158523782851 0.45991707159609 no 1515 0.49073904682316 2358 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1645 Cervolide 78 µM 0.0221036875440236 0.460352196037835 no 1516 0.491182622480521 2336 23173 A fragrance.
SGTC_3281 9140613 49.47 µM 0.0220423706985902 0.460376187085402 no 1517 0.491207078404245 2299 16013766
SGTC_220 paclitaxel 373.376 µM 0.0216286946519693 0.460538047215298 no 1518 0.491372071930095 2352 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_100 0086-0128 49.5915 µM 0.0198730819541228 0.4612250429166 no 1519 0.492072309196276 2362 93297
SGTC_2149 5554786 194.827 µM 0.0191978130607466 0.461489315969526 no 1520 0.492341651103488 2351 745063 YPR165W RHO1
SGTC_927 2425-1185 123 µM 0.0186576407271331 0.46170072991752 no 1521 0.49255711008495 2375 730375
SGTC_2117 5521686 200 µM 0.0185192236483025 0.461754905671299 no 1522 0.492612320970654 2354 803312
SGTC_1488 4013-0813 75.9 µM 0.0184270728324544 0.46179097343422 no 1523 0.492649077554996 2361 2910057
SGTC_1764 st044502 93.5 µM 0.0180605715874557 0.46193442486468 no 1524 0.492795266066127 2357 8407
SGTC_1534 6-azauridine 81.6 µM 0.017712260500842 0.462070761115754 no 1525 0.492934199858711 2378 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_379 3970-0972 5.9 µM 0.0171183478725285 0.462303241221649 no 1526 0.49317110078563 2350 2898042 YBL034C STU1
SGTC_1564 D-Arginine 115 µM 0.0171159868153259 0.462304165455446 no 1527 0.493172042573193 2353 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1333 1482-0047 286 µM 0.0168193237158683 0.462420295586575 no 1528 0.493290376990624 2383 3811116
SGTC_1021 4476-0760 85.3 µM 0.0163236621249977 0.462614331732411 no 1529 0.49348809020466 2370 746768
SGTC_1270 0831-1170 17.3 µM 0.0158455827017831 0.46280149343397 no 1530 0.493678791627892 2372 6764716
SGTC_2425 5628681 7.85 µM 0.0156692942685685 0.462870510078776 no 1531 0.493749111806674 2358 5714958
SGTC_743 1275-0778 158 µM 0.0151142092634521 0.463087832277501 no 1532 0.493970532452094 2374 2849257 YMR203W TOM40
SGTC_1938 st074717 56.4 µM 0.0147544138527231 0.463228702230515 no 1533 0.494114054046988 2383 17250979
SGTC_3264 9137442 49.47 µM 0.0143437651236383 0.463389488311852 no 1534 0.494277861848255 2371 17015726
SGTC_607 4491-0986 66.8 µM 0.0141981127694691 0.463446518713226 no 1535 0.494335962813807 2373 698981 YDR232W HEM1
SGTC_988 1497-1057 103 µM 0.0138903347352179 0.463567032141291 no 1536 0.494458736375625 2382 3533044
SGTC_1761 st044296 37 µM 0.012607131833794 0.464069518391979 no 1537 0.494970615305468 2383 1826700
SGTC_1281 0884-0031 11.8 µM 0.012514253096024 0.464105890781288 no 1538 0.495007665638052 2384 1548255
SGTC_974 1326-0144 138 µM 0.0124724096970114 0.464122277238951 no 1539 0.495024357436366 2371 5411856
SGTC_2801 7907800 81.82 µM 0.0105467656547769 0.464876451654652 no 1540 0.495792527261492 2380 6620925
SGTC_2135 5326629 150.42 µM 0.0101717976029451 0.465023321862253 no 1541 0.49594210984387 2373 5020077
SGTC_2790 5423970 71.43 µM 0.00947887001004247 0.465294745294633 no 1542 0.496218534609449 2375 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.00740892945542094 0.466105647711913 no 1543 0.497044291828651 2382 5282362
SGTC_2569 tetrandrine 100 µM 0.00736733819196603 0.46612194260733 no 1544 0.497060883889296 2384 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_847 0342-0274 5.54 µM 0.006515566203296 0.466455667823697 no 1545 0.497400683552055 2391 18097
SGTC_24 0417-1663 219 µM 0.00631472208211522 0.466534362219798 no 1546 0.497480807114907 2384 4329390
SGTC_2225 6654152 15.4 µM 0.0036622068878637 0.467573787704108 no 1547 0.498538994098631 2397 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2036 5160441 105 µM 0.00364339311001014 0.467581160946436 no 1548 0.498546499659998 2396 134534 YIL048W NEO1
SGTC_2428 5615643 7.78 µM 0.00212806056258134 0.468175065968325 no 1549 0.499151027307114 2396 2253075
SGTC_1400 3771-8998 51.5 µM 0.00181266951554648 0.468298686284855 no 1550 0.499276849885871 2397 670767
SGTC_1570 verbenone 133 µM 0.00105563879755016 0.468595423637222 no 1551 0.499578861129043 2404 29025 A natural terpanoid with antifungal properties.
SGTC_861 0443-0273 110 µM 0.000115331766244655 0.468964025056601 no 1552 0.499953989282274 2405 6149169
SGTC_420 mitomycin C 81.9 mM -0.00114925839163307 0.469459787719551 no 1553 0.499541512337399 2409 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_816 0325-0417 81.3 µM -0.00209020933284944 0.469828703490165 no 1554 0.499166127729431 2412 68101
SGTC_971 1315-0384 26.7 µM -0.00279037982944455 0.470103234029739 no 1555 0.498886800952257 2412 6769120
SGTC_2413 inermin 26.06 µM -0.00398651846560589 0.470572262011413 no 1556 0.498409613444961 2414 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1217 1183-1422 255 µM -0.00454409195803541 0.470790910834255 no 1557 0.498187175830675 2413 2849664
SGTC_2196 6573537 42.6665 µM -0.00484331225786899 0.470908251765926 no 1558 0.498067805517284 2419 2903087
SGTC_1133 3473-0247 50 µM -0.00523074695652978 0.471060190223712 no 1559 0.497913243396822 2426 711311
SGTC_903 1134-0042 114 µM -0.00802103138406907 0.472154566119582 no 1560 0.496800105760408 2427 701009
SGTC_384 k007-0144 5.16 µM -0.00807988863067303 0.472177652780711 no 1561 0.49677662587711 2427 6824886
SGTC_1010 4112-3296 15.2 µM -0.00883169406555117 0.472472555459925 no 1562 0.496476709631823 2418 704384
SGTC_866 0495-0101 262 µM -0.00917315262281968 0.472606500750228 no 1563 0.496340492896846 2428 635694
SGTC_438 sphingosine 6.67 µM -0.0101209194773099 0.472978301164881 no 1564 0.495962406234562 2426 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_793 0488-0545 106 µM -0.0107601557300332 0.4732290811132 no 1565 0.495707401769264 2427 292548
SGTC_671 0560-0003 407 µM -0.011121160038966 0.473370712071322 no 1566 0.495563390506993 2435 3238678
SGTC_3201 9113999 49.47 µM -0.0143455757451023 0.474635877668838 no 1567 0.494277139589112 2456 16649224
SGTC_881 0833-0569 170 µM -0.0147622474960721 0.474799386306808 no 1568 0.494110929215772 2429 5418700
SGTC_1205 4161-2785 76 µM -0.0155667068290854 0.475115080958758 no 1569 0.493790033282577 2486 3498106
SGTC_2995 9067767 71.4286 µM -0.0157669355777868 0.47519365933093 no 1570 0.493710163371709 2450 11673567
SGTC_2950 9072895 21.46 µM -0.0165047704040976 0.475483225753893 no 1571 0.493415848187508 2444 17332245
SGTC_475 α-linolenic acid 10 µM -0.0172239845114301 0.475765496860986 no 1572 0.493128964076472 2450 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_60 0986-0278 202 µM -0.0178300101178035 0.476003354144669 no 1573 0.492887231975157 2430 3110598
SGTC_40 0327-0103 19.753 µM -0.0179260751867448 0.476041059240427 no 1574 0.492848913681722 2448 409036
SGTC_978 1416-0512 87.4 µM -0.0187330601282804 0.476357805539616 no 1575 0.492527027354736 2451 6814003
SGTC_1251 0490-5699 265 µM -0.019213971550096 0.476546573196298 no 1576 0.492335205987701 2444 3883818
SGTC_2947 9072639 7.68 µM -0.0193924908682549 0.476616647054201 no 1577 0.492264000351284 2450 16488146
SGTC_2505 galangin 7.89 µM -0.0198998556382826 0.476815805950026 no 1578 0.492061630153501 2440 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1810 st050138 53 µM -0.0199999156453384 0.476855083781999 no 1579 0.492021719929009 2441 3444541
SGTC_531 3788-1495 174 µM -0.0201069101053038 0.476897083932063 no 1580 0.4919790438969 2445 2896655
SGTC_2759 disulfiram 3.38 µM -0.0205588089454955 0.477074477429069 no 1581 0.491798799607231 2461 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2880 9042983 58.44 µM -0.0206102053313576 0.477094653437795 no 1582 0.491778299759431 2468 6464714
SGTC_2204 7233102 200 µM -0.0237995745522736 0.478346775320817 no 1583 0.490506239706212 2450 2172480
SGTC_1125 tnp00248 1.32998 µM -0.0241096611884592 0.478468524554471 no 1584 0.490382568524765 2462 24207736
SGTC_3140 9094243 49.47 µM -0.0248271391481299 0.478750235419271 no 1585 0.490096421908716 2449 19291112
SGTC_1188 1403-0014 4.57 µM -0.0255500772878278 0.479034100909182 no 1586 0.489808102803794 2456 9614867
SGTC_210 3551-0445 56.827 µM -0.0257449507270683 0.479110620823059 no 1587 0.489730385115033 2470 2865180 YOR207C RET1
SGTC_579 4491-1009 110 µM -0.0267981074318996 0.479524171501029 no 1588 0.489310381363879 2445 1271041
SGTC_33 0986-0033 35.816 µM -0.0269878649743943 0.479598687327402 no 1589 0.489234706427509 2459 2848082
SGTC_1422 4031-0024 15.5 µM -0.0280322146596139 0.480008805349274 no 1590 0.488818228826892 2450 782427
SGTC_1999 st074831 12.5 µM -0.0282979713297514 0.480113171872415 no 1591 0.488712249298846 2480 17112523
SGTC_3178 9107506 49.47 µM -0.0285337851362206 0.480205780537749 no 1592 0.488618211175138 2489 8897194
SGTC_1806 st050005 60.3 µM -0.028664005973326 0.480256921249816 no 1593 0.488566281818235 2467 5194765
SGTC_1893 st059353 36.1 µM -0.0288913085646136 0.480346188973529 no 1594 0.488475638745284 2495 3112488
SGTC_3222 9128301 49.47 µM -0.0301283454136516 0.480832023139082 no 1595 0.487982347308458 2474 4911358
SGTC_3204 9114183 49.47 µM -0.0308122746336279 0.481100641942906 no 1596 0.487709625663325 2460 17027248
SGTC_2059 5238311 157 µM -0.0316944616362247 0.48144714077107 no 1597 0.487357855821774 2470 703021
SGTC_271 rotenone 740 µM -0.0321399404010043 0.481622117938632 no 1598 0.487180226008428 2543 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1261 0712-0010 12.7 µM -0.0321803627253211 0.481637995378029 no 1599 0.487164108171483 2458 2840123
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0324114855859514 0.48172877842563 no 1600 0.487071951564051 2554 61125 An anti-inflammatory.
SGTC_3251 9135047 49.47 µM -0.0327387658031566 0.481857332865444 no 1601 0.486941454904358 2487 17682963
SGTC_2989 9073649 71.4286 µM -0.0329408703592376 0.48193671971886 no 1602 0.486860870317101 2465 21367202
SGTC_294 k038-0071 157 µM -0.0332354146564645 0.482052418268396 no 1603 0.486743428450666 2493 24152826
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0349084054758406 0.482709606251774 no 1604 0.486076389049601 2508 7104
SGTC_884 0851-0618 334 µM -0.0352818962248898 0.482856328198715 no 1605 0.485927479531239 2470 9642473
SGTC_1179 1021-1431 9.29 µM -0.0355838024293388 0.482974930601444 no 1606 0.485807111965692 2510 2840958
SGTC_1288 0973-0013 65.5 µM -0.0356930457168072 0.483017846674114 no 1607 0.485763557867248 2516 4315430
SGTC_2664 lyso-paf C-16 73.48 µM -0.0361953831125972 0.483215191742316 no 1608 0.485563283660732 2470 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2701 st077767 14.721 µM -0.0367677713757315 0.483440061557444 no 1609 0.485335085690377 2492 5721188
SGTC_1089 terbinafine 2.25 µM -0.0374265794629756 0.48369888898643 no 1610 0.485072440083143 2481 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1572 epiandrosterone 68.9 µM -0.0378320481279244 0.483858189803234 no 1611 0.484910795972167 2489 441302 A steroid.
SGTC_120 rhodamine 6G 52.259 µM -0.0387395286629707 0.484214730698428 no 1612 0.484549028867084 2479 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1825 st052143 62.6 µM -0.0394946911007682 0.48451143682464 no 1613 0.484247993052067 2491 674173
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0395144399658839 0.484519196342872 no 1614 0.484240120540143 2473 688667
SGTC_146 3448-8650 53.125 µM -0.039742444467703 0.484608781918969 no 1615 0.484149231299311 2519 2891488 YIL048W NEO1
SGTC_1375 2910-0797 186 µM -0.0401658311648606 0.484775137451227 no 1616 0.483980459208129 2496 742508
SGTC_2938 9059746 27.26 µM -0.0405707068291306 0.484934222176114 no 1617 0.483819068742756 2520 6471769
SGTC_1115 galangin 695.678 nM -0.0410832886441036 0.485135630498649 no 1618 0.483614748542736 2473 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1155 4088-0394 48.2 µM -0.0412686567041375 0.485208467944095 no 1619 0.483540860050334 2472 2326248
SGTC_1734 st037168 69.4 µM -0.0414769381632991 0.485290309435762 no 1620 0.483457838854653 2548 708907
SGTC_624 k048-0052 28 µM -0.0429729301461271 0.485878158036668 no 1621 0.482861556263677 2522 6835531
SGTC_2005 4024620 188 µM -0.0439156467635605 0.486248613462429 no 1622 0.48248582150986 2503 236743
SGTC_1014 4130-3005 69.3 µM -0.0449821684220792 0.486667734330621 no 1623 0.482060761052023 2496 743608
SGTC_1776 st049249 45.9 µM -0.0455232011700221 0.486880354626607 no 1624 0.481845141103335 2504 1822314
SGTC_2884 9058502 51.95 µM -0.0457709890025218 0.48697773394073 no 1625 0.481746390994936 2523 6471554
SGTC_1739 st037196 92.5 µM -0.0459619303271068 0.487052773406402 no 1626 0.481670296510915 2495 612214
SGTC_2878 9043973 25.97 µM -0.0460418660630978 0.487084188088112 no 1627 0.481638440490412 2615 6465167
SGTC_3076 9116187 49.47 µM -0.0470873952572704 0.487495087550792 no 1628 0.481221786661285 2518 27241210
SGTC_2899 9053889 58.44 µM -0.0475540551182356 0.487678492083414 no 1629 0.481035824638292 2502 6470052
SGTC_2601 securinine 100 µM -0.0476091988021186 0.487700164575746 no 1630 0.481013850380364 2506 442872 A GABA receptor antagonist.
SGTC_1809 st050081 57.6 µM -0.0483548791093128 0.487993234331441 no 1631 0.480716709232463 2565 5036894
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0494942199751051 0.48844103433753 no 1632 0.480262721674029 2493 1241132 A phosphatase inhibitor.
SGTC_897 1000-0139 31.4 µM -0.0502046697212011 0.488720272847459 no 1633 0.479979645174651 2486 6151020
SGTC_2980 9014342 25.29 µM -0.0528357463924139 0.489754450680319 no 1634 0.478931389881773 2630 2996599
SGTC_3130 9127414 49.47 µM -0.0543249086833983 0.490339815653046 no 1635 0.478338152296222 2486 1494646
SGTC_2416 tofa 880 nM -0.0551014331946242 0.490645062879521 no 1636 0.478028827178527 2554 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2063 5246145 200 µM -0.0565710450762148 0.491222773533205 no 1637 0.477443450138161 2563 711240
SGTC_895 0964-0006 13.7 µM -0.0567218096543234 0.491282040789103 no 1638 0.477383400195613 2496 6738897
SGTC_2563 tomatine 8.54 µM -0.0579213615066272 0.491753604899965 no 1639 0.476905633831707 2476 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_275 trichlorophene 5.69 µM -0.0587779973195237 0.492090370011619 no 1640 0.476564466875101 2594 62616
SGTC_2172 5754775 163.918 µM -0.0593914619358692 0.492331541880194 no 1641 0.476320156722347 2527 2263357
SGTC_851 0394-0702 453 µM -0.0597835027779339 0.49248566670494 no 1642 0.476164032474674 2515 762646
SGTC_911 3456-4043 236 µM -0.0604333377714588 0.492741141793419 no 1643 0.475905253734197 2567 914281
SGTC_2528 xanthyletin 44.79 µM -0.0610640040389624 0.492989083767653 no 1644 0.475654118122771 2536 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_127 0180-0333 59.125 µM -0.0616173749681194 0.493206639861555 no 1645 0.475433770005139 2505 771601
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0628973637014556 0.493709871164228 no 1646 0.474924117075685 2518 3256 An antibiotic and ribosome inhibitor.
SGTC_1506 4226-2149 212 µM -0.063339409179778 0.493883664999059 no 1647 0.474748117380656 2585 991114
SGTC_3299 9121982 43.1275 µM -0.063567234530793 0.493973236875009 no 1648 0.474657411006344 2547 17594604 YPL160W CDC60
SGTC_1336 1486-0901 104 µM -0.0639077076060775 0.49410709792535 no 1649 0.474521857522415 2603 5006114
SGTC_2151 5563267 85.4165 µM -0.0641030203064907 0.49418388774347 no 1650 0.47444409846892 2566 5310824
SGTC_3302 9125395 16.351 µM -0.0655958298529312 0.494770812828435 no 1651 0.473849804629963 2554 17599668
SGTC_1380 2291-0730 164 µM -0.066135730225559 0.494983087283099 no 1652 0.473634882251698 2579 2999191
SGTC_2330 7979373 200 µM -0.0666913900747449 0.495201559427193 no 1653 0.473413694388863 2546 1863007
SGTC_2395 5646831 180.19 µM -0.0669729532284938 0.495312263869039 no 1654 0.47330161752016 2600 6808628
SGTC_2564 betulinic acid 100 µM -0.0669921704323454 0.495319819664357 no 1655 0.473293968144383 2521 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2047 4141938 200 µM -0.0679175916049806 0.495683677499074 no 1656 0.472925617505917 2536 3807862
SGTC_360 0957-0399 1.01 µM -0.0685979814194239 0.495951196016541 no 1657 0.472654812838828 2599 6752301 YPR165W RHO1
SGTC_3233 9132340 49.47 µM -0.0691123103975612 0.496153423253631 no 1658 0.472450111089944 2527 17682950
SGTC_2845 9003024 42.97 µM -0.0700984124854534 0.496541148052577 no 1659 0.472057665124549 2653 2990173
SGTC_1634 st006576 41 µM -0.0702643904484714 0.496606409144467 no 1660 0.471991612367117 2546 3915356
SGTC_928 2764-0428 58.7 µM -0.07178371395207 0.497203797935588 no 1661 0.471387016882188 2663 662578
SGTC_2532 xanthone 78.9 µM -0.0718492514756593 0.497229567043241 no 1662 0.471360938530815 2580 7020 An insecticide.
SGTC_1784 st039334 36.3 µM -0.0720459486534493 0.497306907702343 no 1663 0.471282670548096 2715 3496984
SGTC_1692 fluoroquinolonic acid 71 µM -0.0721413726382381 0.497344428124182 no 1664 0.471244700688435 2643 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3090 9117696 49.47 µM -0.0724161970070935 0.497452488363828 no 1665 0.471135347644077 2653 7923821
SGTC_2283 7944793 200 µM -0.0735488162639103 0.497897833247161 no 1666 0.470684699734486 2565 2970533
SGTC_1091 telmisartan 47.6 µM -0.0740022149948444 0.498076109989812 no 1667 0.470504311392213 2636 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1935 st074532 41.6 µM -0.0745959296406431 0.498309559637504 no 1668 0.47026810638897 2675 2829742
SGTC_1671 st016596 74.5 µM -0.0752061808160674 0.498549512080355 no 1669 0.470025333351978 2568 2829167
SGTC_3310 9130229 44.1445 µM -0.0752936301015553 0.498583897425267 no 1670 0.469990544770196 2667 7761258
SGTC_2409 alverine citrate 63.97 µM -0.0764068153976803 0.499021606354565 no 1671 0.469547723777706 2836 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3197 9113331 49.47 µM -0.0765326222241812 0.499071074187894 no 1672 0.46949768064615 2610 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3221 9128209 49.47 µM -0.0770493476543173 0.499274253188372 no 1673 0.469292143931397 2587 16460723
SGTC_1469 k284-2957 126 µM -0.0772245686207368 0.499343150986294 no 1674 0.469222448535955 2582 23884841
SGTC_3161 9100388 49.47 µM -0.0780531844235741 0.499668967272685 no 1675 0.468892873471248 2550 25236368
SGTC_2648 atorvastatin 78.68 µM -0.0783120840771664 0.49977076809445 no 1676 0.46878990264059 2551 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1860 st056228 74.6 µM -0.0787320467457144 0.499935899841971 no 1677 0.468622877486389 2657 688679
SGTC_1280 0880-0253 10.1 µM -0.0788345883942034 0.499976219813321 no 1678 0.468582096045263 2582 6836607
SGTC_1552 6-methylflavone 10.6 µM -0.0789555438139308 0.499976219813321 no 1679 0.468533991758445 2548 689013
SGTC_3085 9117376 49.47 µM -0.0792110069142261 0.499875770240888 no 1680 0.468432394925837 2619 16480349
SGTC_817 1391-0715 46 µM -0.0792284884688788 0.499868896392441 no 1681 0.468425442644277 2607 1353946
SGTC_3132 9126706 49.47 µM -0.0796596532238879 0.499699359933234 no 1682 0.468253974747519 2737 850858
SGTC_1628 st004252 77.7 µM -0.0797971009819124 0.499645314694935 no 1683 0.468199315027284 2614 692968
SGTC_513 4245-1575 41.7 µM -0.0804064913940375 0.49940569901944 no 1684 0.467956982118808 2693 719745
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0809138605619663 0.499206198820471 no 1685 0.467755228487781 2604 23847180
SGTC_477 mead ethanolamide 10 µM -0.0819752122621076 0.498788870505634 no 1686 0.467333212424706 2540 16061185
SGTC_3353 9151644 39.2805 µM -0.0824368050979102 0.498607370490274 no 1687 0.467149684701035 2628 4909158
SGTC_1350 1495-0454 146 µM -0.08353207251785 0.498176708499978 no 1688 0.466714238158044 2639 1069057
SGTC_1840 st055363 71 µM -0.0846471734323486 0.49773825011413 no 1689 0.466270947322144 2602 676033
SGTC_1395 3486-0190 4.35 µM -0.0846601499360128 0.497733147759724 no 1690 0.466265788962362 2559 6748079
SGTC_105 0111-0055 734.78 µM -0.085848271751443 0.497265980565772 no 1691 0.465793516390778 2640 5179370
SGTC_1123 mangostin 811.285 nM -0.0863526303403546 0.497067668843021 no 1692 0.465593050860438 2643 5281650 An antioxidant.
SGTC_2647 atorvastatin 60.16 µM -0.0881799312644499 0.496349188062442 no 1693 0.464866833852568 2626 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2919 7978188 46.38 µM -0.0888175022001536 0.496098502703033 no 1694 0.464613473959267 2585 2980291
SGTC_612 0302-0167 22.4 µM -0.0890913069495009 0.495990846377522 no 1695 0.464504672986049 2628 235821
SGTC_2294 7971431 200 µM -0.0905050216484858 0.495434997690439 no 1696 0.463942951816949 2655 5741572
SGTC_3128 9127691 49.47 µM -0.091091487239297 0.495204411887449 no 1697 0.463709948360324 2725 41316314
SGTC_2412 st077135 33.4 µM -0.091346769386247 0.495104040870138 no 1698 0.463608528352093 2857 13258915
SGTC_3249 9135183 49.47 µM -0.0933020400084722 0.494335284572016 no 1699 0.462831805731066 2725 4902779
SGTC_2082 5219693 150 µM -0.0933197849824915 0.494328307849469 no 1700 0.462824757262803 2565 2834649
SGTC_3015 9080845 49.47 µM -0.0936527135753574 0.494197411931036 no 1701 0.462692517104056 2662 5296973
SGTC_397 arbidol 50 µM -0.0957169740608663 0.493385831149453 no 1702 0.461872679723765 2724 131410 A RNA synthesis inhibitor.
SGTC_868 0527-0199 213 µM -0.0971569508043043 0.492819708602437 no 1703 0.461300877265305 2636 2849450
SGTC_345 1362-0200 395 µM -0.0972755267824019 0.492773091440461 no 1704 0.461253795306465 2591 1419823
SGTC_1789 tunicamycin 25 nM -0.0975205481544766 0.49267676363436 no 1705 0.461156508467737 2666 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3253 9135987 49.47 µM -0.0980792260676273 0.492457126368657 no 1706 0.460934691589635 2664 4182430
SGTC_2869 9037858 32.47 µM -0.0988920603437439 0.492137574795184 no 1707 0.460611986466451 2561 27187042
SGTC_2495 cafestol 54.53 µM -0.0992442873766989 0.491999104455049 no 1708 0.460472156080693 2786 16667697 An anti-infammatory.
SGTC_173 1273-0061 2.693 µM -0.101567359317458 0.491085864552469 no 1709 0.459550044459238 2679 2847414 YPL266W DIM1
SGTC_1579 chlormadinone acetate 49.4 µM -0.102566036332564 0.490693281364937 no 1710 0.459153699857823 2698 45114258 A steroidal progestin.
SGTC_695 3505-6186 243 µM -0.102802427205224 0.490600356648323 no 1711 0.45905988942126 2679 1819379
SGTC_2684 capsaicin 100 µM -0.103572213090105 0.490297759122448 no 1712 0.458754419891278 2681 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3265 9137266 49.47 µM -0.104226108310854 0.490040721797332 no 1713 0.458494957683541 2556 17224265
SGTC_2587 piperic acid 92.2 µM -0.104354884504917 0.489990102109558 no 1714 0.458443862043055 2653 5370536
SGTC_2349 9023730 187.07 µM -0.10440231809653 0.489971456828197 no 1715 0.458425041581059 2664 4126287
SGTC_1724 st037281 8.293 µM -0.104487529724907 0.489937961743386 no 1716 0.458391231973708 2604 574124 YDL195W SEC31
SGTC_854 0422-0053 192 µM -0.104552969696763 0.489912238572202 no 1717 0.458365267414843 2600 3596728
SGTC_2101 5377231 179.231 µM -0.104735458104721 0.489840506175359 no 1718 0.458292862591884 2674 2844213
SGTC_569 4130-2812 160 µM -0.105080585188461 0.489704844798728 no 1719 0.45815593238965 2585 743552
SGTC_989 1501-0895 10.3 µM -0.105631451394418 0.489488314663913 no 1720 0.457937384870845 2572 2830112
SGTC_552 k242-0005 476 µM -0.106530502853907 0.489134929304268 no 1721 0.457580727662319 2691 4088318
SGTC_1627 st003713 25.6 µM -0.109070278370813 0.488136680286703 no 1722 0.45657337432132 2679 16195070 YER133W GLC7
SGTC_905 2-aminofluorene 215 µM -0.109340132740523 0.488030619320778 no 1723 0.456466358036509 2604 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2874 9043904 71.43 µM -0.109533142301785 0.487954761218046 no 1724 0.456389818072916 2684 4463428
SGTC_653 0203-0016 55.2 µM -0.109597072769097 0.487929634869859 no 1725 0.456364466132941 2676 295302
SGTC_1341 1486-1360 280 µM -0.109735565693799 0.487875203687345 no 1726 0.45630954669458 2586 3976547
SGTC_3056 9094900 49.47 µM -0.110542539249868 0.487558047425292 no 1727 0.45598955756214 2653 25236784
SGTC_1314 1222-0010 41.1 µM -0.110730383828672 0.487484221983424 no 1728 0.45591507566053 2648 3526027
SGTC_387 norethindrone acetate 66.7 µM -0.112211727656528 0.486902049197528 no 1729 0.455327765287302 2657 541197
SGTC_2245 6637752 200 µM -0.113321928163333 0.486465755134576 no 1730 0.454887666529135 2749 681890
SGTC_1051 3253-3903 78 µM -0.113538457426395 0.486380663879773 no 1731 0.454801837785043 2578 5509239
SGTC_2104 5389443 200 µM -0.113619002534129 0.486349011575728 no 1732 0.454769911528046 2739 2244536
SGTC_718 1130-0073 349 µM -0.113981719347433 0.486206473597748 no 1733 0.454626142419267 2699 6740020
SGTC_891 0929-0073 133 µM -0.114937705283646 0.485830805258935 no 1734 0.454247249315113 2763 5603632
SGTC_2751 anetholtrithion 17.25 µM -0.115189084167865 0.485732024407447 no 1735 0.454147625327841 2713 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2940 9060638 45.86 µM -0.115356068242679 0.485666407489831 no 1736 0.454081449448926 2692 4027022
SGTC_2750 bromebric acid 70.15 µM -0.116174811416506 0.485344685433369 no 1737 0.453756999569217 2715 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_67 0335-0847 266 µM -0.116618154961904 0.485170479219487 no 1738 0.453581325156321 2994 4552207 YOR254C SEC63
SGTC_2067 5224629 34.075 µM -0.117273709756581 0.484912892487472 no 1739 0.453321578913447 2733 2835000
SGTC_2328 6201408 200 µM -0.117384062099547 0.484869532427102 no 1740 0.453277856677818 2687 2890418
SGTC_350 k064-0020 19.8 µM -0.117525826070694 0.484813830253483 no 1741 0.453221689804877 2718 2790705
SGTC_2475 5812728 15.03 µM -0.11800492386 0.484625584423272 no 1742 0.4530318782345 2599 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1803 st050068 52.4 µM -0.119464818884719 0.484051987654677 no 1743 0.452453555425621 2597 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2623 humulene 100 µM -0.120685768714175 0.483572298402116 no 1744 0.451969965758932 2671 6187145 An anti-inflammatory.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.120775664285677 0.483536980978408 no 1745 0.451934363033446 2723 6708739 YPR165W RHO1
SGTC_2974 9094440 9.66 µM -0.121506285503222 0.483249945412688 no 1746 0.451645018240496 2835 25236134
SGTC_875 0709-0210 25.7 µM -0.123868720419892 0.482321887393955 no 1747 0.450709609830037 2603 6251364
SGTC_2642 cholecalciferol 100 µM -0.123906502557416 0.48230704583846 no 1748 0.450694652165669 2676 9821465 A vitamin D precursor, similar to steriods.
SGTC_961 1252-1571 372 µM -0.124924734426074 0.481907073937948 no 1749 0.450291568260698 2717 6813498
SGTC_2421 5690543 90.72 µM -0.125201586425044 0.481798326770864 no 1750 0.450181980671566 2703 3397993
SGTC_1382 3002-2117 298 µM -0.125438664610163 0.481705203791178 no 1751 0.450088139951344 2682 1497314
SGTC_1519 esterone 74 µM -0.125873080131245 0.481534570408182 no 1752 0.449916196051857 2622 698 A steroid.
SGTC_1947 st076332 61.6 µM -0.126454310286301 0.481306275234534 no 1753 0.449686156875035 2694 24208416
SGTC_537 1334-0398 209 µM -0.126908698530428 0.481127805203799 no 1754 0.449506330940541 2619 5846986
SGTC_2218 6965428 192.983 µM -0.12716002177552 0.481029094617218 no 1755 0.449406873229464 2634 675684
SGTC_773 4358-1457 44.6 µM -0.127477676672429 0.480904333046702 no 1756 0.449281170229469 2613 1186886
SGTC_2572 astragaloside iv 100 µM -0.127688346541388 0.480821591755678 no 1757 0.449197806354751 2812 45006101 An anti-inflammatory agent.
SGTC_232 clozapine 119 µM -0.127726490706256 0.480806610596423 no 1758 0.449182712621094 2630 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1468 k284-1086 134 µM -0.12866230736166 0.48043907620291 no 1759 0.448812430907048 2651 15996457
SGTC_2451 5856223 45.7 µM -0.129420460546434 0.480141329873077 no 1760 0.448512479327592 2675 2179896
SGTC_759 3486-0358 89.3 µM -0.130635948020519 0.479663999750468 no 1761 0.448031651995907 2633 875103
SGTC_368 fentichlor 4.58 µM -0.133251362344835 0.478637008691292 no 1762 0.446997295852936 2716 7329 A pesticide.
SGTC_1930 st074634 34.3 µM -0.134114028516411 0.478298297551447 no 1763 0.446656203354177 2646 684253 YOR116C RPO31
SGTC_2307 7538926 6.34 µM -0.136050817775501 0.477537907790655 no 1764 0.445890553816265 2714 96582
SGTC_1607 st000305 50.6 µM -0.139327374825467 0.476251708460622 no 1765 0.444595729431756 2807 5457690
SGTC_2809 7964133 12.99 µM -0.139522476268444 0.476175129843202 no 1766 0.444518648074331 2692 1253665
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.140396487347311 0.475832085506992 no 1767 0.444173366528553 2775 5024745
SGTC_1073 triclabendazole 3.09 µM -0.140522518653984 0.475782620413639 no 1768 0.444123580849578 2705 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_616 4092-0450 108 µM -0.140809918876183 0.475669822227948 no 1769 0.444010053506322 2708 787165
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.140944301985869 0.475617080519088 no 1770 0.443956971763959 2643 6312947
SGTC_1906 st060206 94.7 µM -0.141783279171792 0.475287814530187 no 1771 0.443625595959741 2717 5133468
SGTC_163 TUB2.036 7.546 µM -0.141924165006969 0.475232523955786 no 1772 0.443569953303284 2668 15992207 YJR013W GPI14
SGTC_2281 7943571 200 µM -0.142150038640825 0.475143880958753 no 1773 0.44348074716106 2730 1244024
SGTC_2835 9006588 71.43 µM -0.14248901807119 0.475010852458078 no 1774 0.443346876587241 2888 2345538
SGTC_2365 9042475 200 µM -0.14408287501211 0.474385399588401 no 1775 0.442717513686702 2737 6464479
SGTC_871 0574-0004 149 µM -0.144542736730083 0.474204954763402 no 1776 0.442535955861996 2668 9551173
SGTC_3179 9107801 49.47 µM -0.145717652309421 0.473743954561411 no 1777 0.442072142793963 2693 4818259
SGTC_1465 k213-0056 144 µM -0.146149817649026 0.473574395182828 no 1778 0.441901559897085 2651 24048857 YMR208W ERG12
SGTC_391 gliotoxin 8.33 µM -0.147317276509718 0.473116368591418 no 1779 0.44144079828623 2793 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2761 levamisole 97.89 µM -0.147398357527431 0.473084559565325 no 1780 0.441408800933349 2744 26879 An alkaline phosphatase inhibitor.
SGTC_1452 4194-0072 190 µM -0.147935183331072 0.472873960899677 no 1781 0.441196960700615 2844 1343545
SGTC_674 0498-0004 451 µM -0.147970058179785 0.472860279634567 no 1782 0.441183199096829 2716 4231473
SGTC_3153 9100258 49.47 µM -0.148562341501257 0.472627934134107 no 1783 0.440949495151492 2704 25236848
SGTC_1653 st012112 65 µM -0.150645677638134 0.471810741376759 no 1784 0.440127613498754 2818 720429
SGTC_2177 5811945 192 µM -0.151292430652567 0.471557075191801 no 1785 0.4398725200091 2823 5343475
SGTC_588 3970-1144 52.9 µM -0.151400193909822 0.4715148099526 no 1786 0.43983001825399 2820 1888707
SGTC_1706 st031321 9.9705 µM -0.151518195606746 0.471468529518823 no 1787 0.439783479260659 2784 6103185
SGTC_1309 pyrazolanthrone 13.4 µM -0.152750484548772 0.47098524717627 no 1788 0.439297523484728 2751 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1561 5-methoxyflavone 52.9 µM -0.1538038237696 0.470572179652328 no 1789 0.438882209391154 2656 94525
SGTC_3259 9138485 49.47 µM -0.154420827674971 0.470330235925717 no 1790 0.438638966255749 2898 17646153
SGTC_1792 st045773 43.6 µM -0.154499770322272 0.470299281191643 no 1791 0.438607846150547 2672 2919270
SGTC_2080 5212524 12.4 µM -0.158712355007242 0.468647721228015 no 1792 0.436947751839197 2685 260183
SGTC_1359 1582-0056 520 nM -0.160302013707397 0.468024628090861 no 1793 0.436321586340276 2796 3661189
SGTC_2165 5727197 32.143 µM -0.160720176441651 0.467860735210032 no 1794 0.436156898759859 3099 1361712
SGTC_2988 9073640 71.4286 µM -0.161074534656272 0.467721853857827 no 1795 0.436017348365014 2860 9102229
SGTC_2251 lansoprazole 556 µM -0.161615733882433 0.467509752689068 no 1796 0.435804233179805 2698 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1778 st046819 58.9 µM -0.164323287201932 0.466448776276638 no 1797 0.434738325165254 2702 671715
SGTC_2290 7904846 200 µM -0.165335832246768 0.466052063245009 no 1798 0.434339828424235 2778 2962154
SGTC_2858 9025781 8.96 µM -0.166176987083296 0.465722526170656 no 1799 0.434008834639653 2808 4894980 YPL153C RAD53
SGTC_700 3453-2283 142 µM -0.166896921507402 0.465440497963841 no 1800 0.433725577728964 2874 565664
SGTC_3098 9119039 49.47 µM -0.167618968588126 0.465157659575683 no 1801 0.433441523780041 2687 17161528
SGTC_712 r015-0009 80.6 µM -0.168258143655128 0.464907298277969 no 1802 0.433190100433475 2820 6813872 YLR060W FRS1
SGTC_1846 st056244 14.8 µM -0.169625562411099 0.464371734776551 no 1803 0.432652308987477 2777 5393182
SGTC_2848 9016370 25.97 µM -0.170070311242392 0.464197558224615 no 1804 0.432477420772768 2736 7894410
SGTC_1493 4348-0038 111 µM -0.170302408569611 0.464106664896689 no 1805 0.432386158583585 2725 800424
SGTC_282 k297-0036 65.7 µM -0.170725588967507 0.463940944957922 no 1806 0.432219770567285 2850 5061378
SGTC_2879 9041815 71.43 µM -0.171541577846053 0.463621416588926 no 1807 0.43189897026643 2707 4942971
SGTC_386 1509-0011 3.07 µM -0.172117898183355 0.463395752766049 no 1808 0.431672421014027 2708 3107280
SGTC_3013 9080133 71.4286 µM -0.172879633009817 0.463097506182615 no 1809 0.43137302054767 2902 17050193
SGTC_3203 9113543 49.47 µM -0.173727627929577 0.462765510075069 no 1810 0.431039761866584 2897 17018012
SGTC_542 3381-0244 89.3 µM -0.174530363070327 0.462451257388241 no 1811 0.43072433532927 2891 1112843
SGTC_899 1083-0020 478 µM -0.175333297272556 0.462136950217504 no 1812 0.430408874777926 2892 767123
SGTC_742 0kpi-0133 140 µM -0.175622011476857 0.462023939322563 no 1813 0.430295454233099 2884 2728852
SGTC_708 3448-5400 146 µM -0.17593629079171 0.461900925006586 no 1814 0.430171997045596 2742 3462195
SGTC_562 3772-2733 112 µM -0.176357849469653 0.461735925432321 no 1815 0.430006408421517 2814 2876874 YIL048W NEO1
SGTC_2387 9077560 195.08 µM -0.176379837311879 0.461727319492692 no 1816 0.429997771915051 2713 5303272
SGTC_228 caffeine 993.056 µM -0.177478786528069 0.461297218771358 no 1817 0.429566163309644 2856 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.178082484345996 0.461060966058382 no 1818 0.429329098811965 2744 390807
SGTC_462 ag-879 158 µM -0.178278666540757 0.460984194549954 no 1819 0.429252066027842 2830 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2905 7799065 20.05 µM -0.179692436978536 0.460430990320811 no 1820 0.428697015608063 2859 1296806
SGTC_3268 9137683 49.47 µM -0.180360601945569 0.46016956591037 no 1821 0.428434741079368 2698 1953228
SGTC_750 4073-0104 132 µM -0.180901573230463 0.459957919561996 no 1822 0.428222416983862 2800 22330957
SGTC_3 0833-0587 95.581 µM -0.183315448492054 0.459013668634428 no 1823 0.427275256821801 2769 5382644
SGTC_1475 4092-1048 11.7 µM -0.184081226596655 0.458714162398208 no 1824 0.426974866905824 2794 2881759
SGTC_1973 st070275 50.2 µM -0.184778467094388 0.458441482531141 no 1825 0.426701398892686 2687 17118334
SGTC_2649 anisomycin 9.56 µM -0.185031543290473 0.458342513214645 no 1826 0.426602147381309 2778 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_645 0845-0943 5.41 µM -0.185040029331116 0.458339194663398 no 1827 0.42659881940341 2781 1885106
SGTC_2646 retinol 96.75 µM -0.185804746542241 0.458040156282827 no 1828 0.426298941075392 2809 445354 A vitamin A analog and teratogen.
SGTC_273 hydroxyurea 18.1 mM -0.18703259019268 0.457560064652767 no 1829 0.425817540256546 2728 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1624 st003710 6.25 µM -0.187274741580851 0.45746538980882 no 1830 0.425722612958145 2918 24207033
SGTC_1292 0kpi-0043 232 µM -0.188499967022761 0.456986395898138 no 1831 0.42524237068237 2795 3333905
SGTC_748 act1.228 77.9 µM -0.190009174650004 0.456396466959879 no 1832 0.424650970585683 2744 4421505 YNR035C ARC35
SGTC_910 3454-3003 490 µM -0.190544595277383 0.456187201273221 no 1833 0.424441200633136 2790 820824
SGTC_2926 9010726 65.15 µM -0.192069465932415 0.455591282230243 no 1834 0.423843896121825 2854 2994293
SGTC_1055 3448-0672 86 µM -0.192098897679271 0.45557978128986 no 1835 0.423832369178221 2898 748378
SGTC_1175 0741-0056 27.6 µM -0.192492444270114 0.455426000050802 no 1836 0.423678242922323 2928 765927
SGTC_3129 9127257 49.47 µM -0.192793580878506 0.455308333204485 no 1837 0.423560315448336 2779 837894
SGTC_2739 tacrine 100.86 µM -0.192824022725648 0.45529643850157 no 1838 0.423548394561447 2842 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_979 1426-2828 121 µM -0.193244321037775 0.455132217234171 no 1839 0.423383814838616 2883 747872
SGTC_81 0411-0046 9.971 µM -0.193505935008727 0.45503000185472 no 1840 0.423281379217158 2731 12925265
SGTC_917 harmaline 728.087 nM -0.195493315576964 0.454253608685378 no 1841 0.422503385063477 2862 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_790 1575-0012 79.1 µM -0.195731691453274 0.45416049607605 no 1842 0.4224100889847 2919 378741 YLR208W SEC13
SGTC_1101 ebselen 5.29 µM -0.195970147155123 0.454067354806335 no 1843 0.422316766018695 2889 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3091 9116372 49.47 µM -0.196594705580245 0.453823413032908 no 1844 0.422072357046936 2916 17169793
SGTC_2857 9024691 58.44 µM -0.196667048876883 0.453795158110115 no 1845 0.422044048821537 2866 16478292
SGTC_2736 butenafine 14.65 µM -0.196791017911717 0.453746740408276 no 1846 0.421995540171892 2785 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2069 5228469 200 µM -0.197352362920678 0.453527508505813 no 1847 0.421775902655587 2886 2835210
SGTC_3033 9090887 49.47 µM -0.199761039655302 0.45258696734836 no 1848 0.420833736489921 2769 19325384
SGTC_745 0469-0705 296 µM -0.200843549358536 0.452164354791626 no 1849 0.420410454610425 2923 3486736
SGTC_55 0767-0285 6.563 µM -0.201216524044205 0.452018757738192 no 1850 0.420264635705598 2875 3116166
SGTC_2297 7971671 152.32 µM -0.201575976912824 0.451878445263381 no 1851 0.420124113671506 2917 909016
SGTC_499 genistein 192 µM -0.201829631529407 0.451779434766576 no 1852 0.420024957805312 2825 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_481 bay k-8644 50 µM -0.201870866248321 0.451763339659724 no 1853 0.420008839263111 2779 2303 A calcium channel antagonist.
SGTC_2255 7941087 197.44 µM -0.2019175026142 0.451745136228928 no 1854 0.419990609393134 2915 935561
SGTC_2799 7812892 81.82 µM -0.202162066312568 0.451649678086596 no 1855 0.419895013751716 2934 20205235
SGTC_3326 9140064 16.379 µM -0.204187774339362 0.450859111386218 no 1856 0.419103382382905 2743 1868434
SGTC_3119 9125183 49.47 µM -0.204771215446631 0.450631449674654 no 1857 0.418875438598759 2836 22695334
SGTC_234 nsc-17383 10.7 µM -0.209230894703575 0.448891801936971 no 1858 0.417133997822084 2918 408974
SGTC_1214 0358-0031 63.7 µM -0.210013236821322 0.448586723418416 no 1859 0.416828670962732 3057 4301366
SGTC_976 1348-1067 47.6 µM -0.210994692663848 0.448204042442662 no 1860 0.416445706387601 2792 5310671 YGL099W LSG1
SGTC_1225 1216-0074 20.6 µM -0.211135156370063 0.448149277954392 no 1861 0.41639090385537 2807 4241466
SGTC_515 4092-1064 102 µM -0.211667740152472 0.44794164128466 no 1862 0.416183128724686 3004 717353
SGTC_942 3253-1115 227 µM -0.212342755877863 0.44767849564821 no 1863 0.415919820757886 2952 46497897
SGTC_1712 st032288 53.4 µM -0.212694029575215 0.447541565509809 no 1864 0.415782811964042 2840 2883011
SGTC_1609 st001574 46.4 µM -0.214515021131863 0.446831824642938 no 1865 0.415072727212439 2783 3960012
SGTC_3068 9116768 49.47 µM -0.217238507855142 0.445770650047351 no 1866 0.414011238120134 2887 41904888
SGTC_1660 st012960 28.1 µM -0.217811222871335 0.445547547538159 no 1867 0.41378809995386 2897 24207266
SGTC_1854 st056233 32.9 µM -0.218250987176013 0.445376247997097 no 1868 0.413616780221599 2777 5393174
SGTC_1812 st052057 4.327 µM -0.218911382627595 0.445119026098427 no 1869 0.413359539731381 2764 3645418
SGTC_1215 3852-0577 11.2 µM -0.220321150708784 0.444570003417005 no 1870 0.412810524478525 2957 2884876
SGTC_2146 5545642 200 µM -0.220958105210695 0.444321981491655 no 1871 0.412562526956209 2806 825326
SGTC_1260 0700-1617 7.75 µM -0.22368843191093 0.443259075449302 no 1872 0.411499873940623 2909 2853078
SGTC_1242 0402-0103 60.1 µM -0.226508569972661 0.442161634748388 no 1873 0.41040294727793 2780 432868
SGTC_2315 7733312 200 µM -0.22751849256915 0.441768736579949 no 1874 0.410010295630864 2830 726316
SGTC_2404 5161160 200 µM -0.227859536664049 0.441636070420432 no 1875 0.409877720156912 2768 2831543
SGTC_89 0302-0250 142.109 µM -0.22787260951855 0.441630985209979 no 1876 0.409872638497329 2782 4203518 YLR208W SEC13
SGTC_1786 berberine 21.6 µM -0.228119343488611 0.441535009953548 no 1877 0.40977673129384 2807 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1755 st041960 45.185 µM -0.228691733635082 0.441312373292643 no 1878 0.4095542600745 2936 2257073
SGTC_1701 st028638 40.4 µM -0.229172500351526 0.4411253887732 no 1879 0.409367422686431 2927 3490878
SGTC_3038 9091290 49.47 µM -0.229543644011456 0.440981048904693 no 1880 0.40922320150405 2953 25236843
SGTC_1925 st057770 10.1 µM -0.231011730715768 0.440410178702179 no 1881 0.408652844352989 2806 5989122
SGTC_2754 granisetron 64.02 µM -0.231289703932365 0.440302101837152 no 1882 0.408544872464382 2957 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_235 0330-0087 5 mM -0.231367335831672 0.440271919103529 no 1883 0.40851471949393 2833 46494818 YHR062C RPP1
SGTC_204 PMA1.184 62.41 µM -0.232700778078862 0.4397535405078 no 1884 0.407996882490062 2792 2252213 YGL008C PMA1
SGTC_3144 9087057 49.47 µM -0.233411736596967 0.43947719597895 no 1885 0.407720850180525 2810 17249618
SGTC_2722 naftopidil 47.16 µM -0.233808864912799 0.439322847850028 no 1886 0.407566683552688 2858 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2003 4023581 200 µM -0.234075725898182 0.439219134680142 no 1887 0.407463095206598 2953 16641307
SGTC_3117 9124945 49.47 µM -0.23408991972637 0.439213618490715 no 1888 0.407457585720684 2781 17592065
SGTC_585 0kpi-0023 191 µM -0.234261004210899 0.439147130350448 no 1889 0.407391178892305 2958 64601
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.237807430253233 0.437769280947056 no 1890 0.406015227733497 2811 1377
SGTC_122 0236-0016 402.397 µM -0.237845774925585 0.437754387453357 no 1891 0.406000356981707 2860 6808838
SGTC_1149 3909-7961 23.3 µM -0.238591929733254 0.437464590274592 no 1892 0.405711011784371 2837 735261
SGTC_2691 st077356 60.2 µM -0.239239814619726 0.437212987104718 no 1893 0.405459815639016 2989 2839272
SGTC_2129 girgensonine 121.053 µM -0.239761146721851 0.437010548567722 no 1894 0.405257714454227 2904 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_806 3966-4455 5.86 µM -0.239775215341699 0.4370050858084 no 1895 0.405252260920161 2826 714982
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.241372346913511 0.436385007685533 no 1896 0.404633271595607 2822 229346 A bile salt which induces apoptosis.
SGTC_2233 sulbentine 40.3845 µM -0.241925032505408 0.436170466670475 no 1897 0.404419126521845 2851 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2018 5133068 143 µM -0.242483028162056 0.435953883449084 no 1898 0.404202953041086 2797 785362
SGTC_20 0481-0013 4.944 µM -0.242646407858319 0.435890472069594 no 1899 0.404139663533317 2843 182045
SGTC_423 5-fluorouracil 457 µM -0.243357202543153 0.435614615673248 no 1900 0.403864347368685 2782 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1187 1391-0724 117 µM -0.244069273750376 0.435338295273295 no 1901 0.403588584509026 2860 6997986
SGTC_2698 st077697 67.5 µM -0.245599674316384 0.43474452783385 no 1902 0.402996070685734 2885 3154499
SGTC_3088 9117578 49.47 µM -0.246130017022608 0.434538798823357 no 1903 0.40279079372245 2893 678341
SGTC_2271 7849410 118.62 µM -0.247228342407877 0.434112796038763 no 1904 0.402365755953751 2821 972430
SGTC_2022 5136654 200 µM -0.247263714635798 0.434099077632555 no 1905 0.402352069272922 2995 1713771
SGTC_2397 5161689 200 µM -0.248239699896368 0.43372059276893 no 1906 0.401974475682451 3058 2259942
SGTC_3291 9121177 71.43 µM -0.248913796300586 0.433459215174476 no 1907 0.40171373160429 2876 17015612
SGTC_2877 9040724 71.43 µM -0.252154114501538 0.432203205702227 no 1908 0.400460971800656 3057 6463895
SGTC_346 4513-0042 7.16 µM -0.25303294093878 0.431862673256214 no 1909 0.400121379047471 2854 2827372
SGTC_509 pifithrin 175 µM -0.253108660651368 0.431833335335474 no 1910 0.400092123255151 2909 4817 A p53 inhibitor.
SGTC_1732 st034308 51.822 µM -0.253120156663434 0.431828881190173 no 1911 0.400087681595006 2777 830119
SGTC_1105 epirubicin 18.1 µM -0.253166437782641 0.431810949596114 no 1912 0.400069800307279 2842 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2046 4110841 106 µM -0.257739767051577 0.430039714411867 no 1913 0.398303876506494 3018 44119630 YMR134W ERG29
SGTC_188 3229-0966 278.469 µM -0.258025313673535 0.429929169456007 no 1914 0.398193685522724 2919 5722370
SGTC_2155 5570423 76 µM -0.259101117979387 0.429512737867555 no 1915 0.397778611112541 2882 797402
SGTC_2939 9044578 71.43 µM -0.259151704974282 0.429493158145146 no 1916 0.397759096125365 2834 2653634
SGTC_2730 imipramine 71.33 µM -0.259467243764126 0.429371032610979 no 1917 0.397637376240052 2876 3696 A tricyclic antidepressant.
SGTC_1145 3546-0597 10.2 µM -0.259897761114898 0.42920441689808 no 1918 0.397471319159935 2912 875334
SGTC_409 arachidonic acid 100 µM -0.260019022701155 0.42915748939083 no 1919 0.397424550076911 2879 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.260146994228768 0.429107966262383 no 1920 0.397375194652392 2977 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_155 k072-0202 43.6 µM -0.26029873606355 0.429049245815304 no 1921 0.3973166737429 2813 5857737
SGTC_877 0771-0151 33.1 µM -0.260472317803018 0.428982075774969 no 1922 0.397249732868135 2951 6166523
SGTC_2462 5162487 171.77 µM -0.261543470379165 0.42856762290219 no 1923 0.396836715608262 2820 2259986
SGTC_1113 artemisinin 1.17947 µM -0.26367507438273 0.427743092433892 no 1924 0.396015151884747 2975 2240 An anti-malaria and mitochondrial poison.
SGTC_606 k015-0008 38.6 µM -0.263961275201966 0.427632410402408 no 1925 0.395904879318211 3009 1970475
SGTC_2728 chlorpromazine 9.18 µM -0.264329211795399 0.427490127180326 no 1926 0.395763126371626 2847 2726 A thorazine and dopamine antagonist.
SGTC_2788 5282734 71.43 µM -0.264578987243285 0.427393542933626 no 1927 0.395666904586872 3029 743706
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.264671177119591 0.427357895654077 no 1928 0.395631391595898 2933 4213774
SGTC_2273 7815444 169.05 µM -0.264912167883552 0.427264713982354 no 1929 0.395538562255437 3058 2824616
SGTC_536 3852-0578 10.6 µM -0.265161444913854 0.427168332606177 no 1930 0.395442547290937 3046 2869208
SGTC_1714 st033236 13.627 µM -0.265279875208908 0.427122543809823 no 1931 0.395396933275421 3047 2916566
SGTC_761 k216-0224 480 µM -0.266398135877993 0.426690238313808 no 1932 0.394966300364201 3075 1340404
SGTC_850 0388-0143 75.9 µM -0.266536949986003 0.426636580660182 no 1933 0.394912853141472 2895 67273
SGTC_2787 5284540 71.43 µM -0.267531436900083 0.426252208240912 no 1934 0.39453000640692 2950 736958
SGTC_2458 5808907 16.39 µM -0.268215482156306 0.425987863165951 no 1935 0.394266729216522 3044 2731747
SGTC_2213 7173844 200 µM -0.268488385754647 0.425882410525129 no 1936 0.394161706812727 2898 892728
SGTC_1673 st016611 27.3 µM -0.268880465322125 0.425730916394395 no 1937 0.394010834993346 3077 5226799
SGTC_733 4069-0007 56.1 µM -0.270296883043303 0.425183723636719 no 1938 0.393465931559023 2893 5717425 YNL287W SEC21
SGTC_2979 9012552 45.46 µM -0.271268190018195 0.424808569996925 no 1939 0.393092385094183 2991 17100905
SGTC_1194 1488-0194 225 µM -0.273081388879507 0.424108429925687 no 1940 0.392395326360915 2860 1391452
SGTC_2448 5185112 27.17 µM -0.273118902289698 0.424093947194804 no 1941 0.392380908495432 3022 5718189
SGTC_1193 1488-0126 41.5 µM -0.27446076270354 0.423575965256819 no 1942 0.391865276533051 2904 1384710
SGTC_1908 st060353 56.5 µM -0.275215454822702 0.423284698657948 no 1943 0.391575357024211 3095 4227716
SGTC_754 3474-0146 171 µM -0.275854604222718 0.423038057504405 no 1944 0.391329871027751 2881 24762078
SGTC_342 k048-0088 23.3 µM -0.276729148258416 0.42270062887821 no 1945 0.390994044249737 2848 6820570
SGTC_2437 5741531 144.16 µM -0.27689321231038 0.422637333735646 no 1946 0.39093105234869 3075 2262990
SGTC_3110 9122132 49.47 µM -0.277250808812496 0.422499381603948 no 1947 0.390793764161298 3053 918317
SGTC_2087 5276107 200 µM -0.277594311855715 0.422366875340459 no 1948 0.390661899540691 2873 144405
SGTC_2853 9015042 58.44 µM -0.278432254563315 0.422043675912598 no 1949 0.39034028122833 2837 6457456
SGTC_298 1391-0729 10 µM -0.27878044088773 0.421909393825987 no 1950 0.390206662762998 2896 3237558
SGTC_3252 9135871 49.47 µM -0.279015881412852 0.421818598606011 no 1951 0.390116318482894 3039 17682838
SGTC_2836 9010338 19.48 µM -0.280954745470606 0.421071054053156 no 1952 0.38937255507963 2917 2994051
SGTC_302 1094-0063 18.9 µM -0.280981981949254 0.421060554830693 no 1953 0.389362109832471 2879 5440289
SGTC_2491 paeonol 100 µM -0.281235147606166 0.420962966247355 no 1954 0.389265024093345 2843 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1981 st071826 47 µM -0.282039944530489 0.420652770862171 no 1955 0.388956440872701 2995 11838600
SGTC_2718 lomofungin 53.02 µM -0.283251312729466 0.420185962381644 no 1956 0.388492098163235 3071 5351222 A RNA synthesis inhibitor.
SGTC_1384 3089-0840 101 µM -0.284431824844179 0.419731152478809 no 1957 0.388039736493504 3032 1069836
SGTC_2121 5257820 149.641 µM -0.285898609246798 0.41916620130616 no 1958 0.387477889484724 3073 791256
SGTC_1684 st024538 14.6195 µM -0.285962639757991 0.419141542905556 no 1959 0.387453368163018 2908 6732859
SGTC_1870 st057514 26.5 µM -0.287627366224516 0.418500561968322 no 1960 0.386815997242763 2874 5393161
SGTC_573 3702-0553 84.7 µM -0.288948305450638 0.417992105619316 no 1961 0.38631046856947 2920 1222756
SGTC_51 1013-0126 23.419 µM -0.290384179416734 0.417439564017818 no 1962 0.385761172766018 3191 1627850
SGTC_693 4161-2696 114 µM -0.290780900091829 0.417286929812506 no 1963 0.385609446988162 3020 805759
SGTC_1244 0416-0015 52.5 µM -0.290836510362547 0.417265535327452 no 1964 0.38558818024445 2934 96201
SGTC_1747 st037496 66.6 µM -0.291275463819058 0.417096668953708 no 1965 0.385420325657374 2945 723305
SGTC_1722 st034304 3.6505 µM -0.292378050027191 0.41667256909658 no 1966 0.384998794459923 2932 4036148 YLR033W RSC58
SGTC_2911 7942208 15.64 µM -0.29267754907895 0.416557386209661 no 1967 0.384884316025673 3002 1243384
SGTC_853 0419-0306 21 µM -0.293518287822257 0.416234088889384 no 1968 0.384563011546555 2900 762713
SGTC_1443 4112-3303 14 µM -0.294850857960109 0.415721779103925 no 1969 0.384053906736668 2933 704433
SGTC_1472 k841-0093 193 µM -0.295776202549067 0.415366112352494 no 1970 0.383700498951 3049 X1472
SGTC_1035 k081-0041 55.2 µM -0.296177698321675 0.41521181442238 no 1971 0.383547189675834 3083 731709
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.296628735859974 0.41503849280525 no 1972 0.383374984853644 2953 65057 A dermal irritant. YDR527W RBA50
SGTC_2519 cryptotanshinone 88.04 µM -0.296745785372326 0.414993516520931 no 1973 0.383330299453537 3092 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_710 3448-4187 58 µM -0.298628860646659 0.414270098231079 no 1974 0.38261162105724 2970 3946412
SGTC_1274 0865-0114 173 µM -0.299300810374358 0.414012026538672 no 1975 0.382355268162327 2973 870624
SGTC_1813 st051246 8.6015 µM -0.299925282050194 0.413772222738588 no 1976 0.382117074646056 3039 5291959
SGTC_3266 9136860 49.47 µM -0.300053591245284 0.413722954614836 no 1977 0.382068138927393 3038 4871271 YPR165W RHO1
SGTC_1575 cyproterone acetate 48 µM -0.301077895221953 0.413329691461296 no 1978 0.381677548247253 2999 9880 An androgen receptor antagonist and liver toxin.
SGTC_2492 derrusnin 100 µM -0.302033210730716 0.412962993535129 no 1979 0.381313372993527 2869 1715307 Part of coumarin class of compounds.
SGTC_839 0122-0028 230 µM -0.304772011144743 0.411912126740467 no 1980 0.380269899933467 2966 759448
SGTC_2916 7875993 68.79 µM -0.306428134473089 0.411276984670813 no 1981 0.379639344881263 3000 1299250
SGTC_621 3584-0052 32.1 µM -0.307177284045502 0.410989753581323 no 1982 0.379354217465237 3057 2273927
SGTC_1612 st002233 45.4 µM -0.309738194498609 0.410008237344288 no 1983 0.378380027567936 2994 1035021
SGTC_648 0375-0473 33.3 µM -0.311287941359341 0.409414541542418 no 1984 0.377790866813226 2948 1713139
SGTC_2846 9008642 19.48 µM -0.312930432581159 0.408785542828666 no 1985 0.37716675802144 3079 2992898
SGTC_1830 st055982 50.3 µM -0.314127099312354 0.40832742221002 no 1986 0.376712254111553 3082 455313 An antimicrobial agent.
SGTC_1516 st013856 110 µM -0.314465442142277 0.408197916916505 no 1987 0.376583779660413 3062 5281404 A mutagen and neurotoxin.
SGTC_778 3456-2434 196 µM -0.315048027671303 0.407974947931582 no 1988 0.376362594195224 3096 5539063
SGTC_2589 lobaric acid 100 µM -0.317338196127748 0.407098736845691 no 1989 0.375493498809901 2991 73157 A novel microtubule depolymerizer.
SGTC_2674 ligustilide 100 µM -0.319182291904517 0.406393529273242 no 1990 0.374794142125332 3057 5319022 A signalling regulator.
SGTC_789 1309-1135 70.6 µM -0.321706841242506 0.4054285994869 no 1991 0.373837397301475 2941 3092424
SGTC_3108 9121785 49.47 µM -0.322471124762515 0.405136589105886 no 1992 0.373547904738259 2893 17140271
SGTC_2534 helenine 20.12 µM -0.323937875117531 0.404576334733119 no 1993 0.3729925342697 2926 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2714 st079313 56.9 µM -0.324447660240775 0.404381657945112 no 1994 0.37279957091637 2972 2939799
SGTC_867 0518-0118 155 µM -0.324484199407987 0.404367705273319 no 1995 0.372785741372602 3072 6848158
SGTC_1827 berberine 7.24 µM -0.325483902807332 0.403986010555939 no 1996 0.372407431833455 2975 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3169 9102970 49.47 µM -0.326970502246408 0.403418584165378 no 1997 0.371845097919922 3006 17027839
SGTC_923 1900-2434 73.3 µM -0.32712136694801 0.403361011323717 no 1998 0.371788045792645 2932 5910570
SGTC_1403 3909-7815 62.9 µM -0.327490940263215 0.403219983964403 no 1999 0.371648297074339 2951 6615483
SGTC_1795 st049545 62.3 µM -0.328107193678112 0.40298485269261 no 2000 0.371415307523757 3114 5291882
SGTC_2436 5633522 8.09 µM -0.3288214861154 0.402712358563822 no 2001 0.371145310890079 3157 5724242
SGTC_2913 7966556 36.57 µM -0.329611810874607 0.402410914072595 no 2002 0.370846648563889 3119 2976516
SGTC_2678 equilin 100 µM -0.330068310930044 0.402236822926106 no 2003 0.370674173434668 3087 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_137 0438-0332 85.389 µM -0.330373097079392 0.402120600282519 no 2004 0.370559033410669 3073 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1748 st037455 53.6035 µM -0.331167902357032 0.401817561721103 no 2005 0.370258831875659 3160 580690
SGTC_2984 9022109 38.96 µM -0.33166114392719 0.401629531218534 no 2006 0.37007257202989 3106 6459207
SGTC_837 0091-0265 12.5 µM -0.332649183515376 0.401252945411472 no 2007 0.36969955627011 2989 759367
SGTC_2126 5251174 33.877 µM -0.333015575019974 0.40111332061449 no 2008 0.369561263188644 3165 790722
SGTC_889 0919-1524 82.7 µM -0.334293751347293 0.400626331036866 no 2009 0.369078952597792 3047 3905452
SGTC_315 k915-0449 187 µM -0.336487972688586 0.399790685623555 no 2010 0.368251459890597 3035 20970215 YNL149C PGA2
SGTC_686 1319-0111 510 µM -0.337380327115589 0.399450973114005 no 2011 0.367915106447843 3161 4562600
SGTC_713 1488-1073 324 µM -0.338288388963071 0.399105359044889 no 2012 0.367572936375889 2986 3312542
SGTC_2237 6667747 47.222 µM -0.339204881084998 0.398756616539861 no 2013 0.367227696224498 2972 729940 YDL015C TSC13
SGTC_1757 st041620 31.8375 µM -0.3394874411104 0.398649113417515 no 2014 0.367121278242896 3054 5289815
SGTC_3180 9109287 49.47 µM -0.340805424394179 0.398147773643634 no 2015 0.366625033302192 3119 18891271
SGTC_1146 3579-1023 7 µM -0.34190461607038 0.397729787216962 no 2016 0.36621133782276 3126 X1146
SGTC_1254 0550-0035 264 µM -0.342910178917991 0.397347507543207 no 2017 0.365833016941486 3143 15121435
SGTC_1410 3909-8106 77.9 µM -0.345348305708022 0.396421027342423 no 2018 0.364916267594004 3109 1039210
SGTC_2821 7996764 71.43 µM -0.345826635745569 0.396239331923247 no 2019 0.364736503202428 3238 2987135
SGTC_1245 0418-0076 17.2 µM -0.345928706901117 0.396200562736657 no 2020 0.364698147011076 3180 6790114
SGTC_1445 4239-0156 97.7 µM -0.345986939468502 0.396178445005938 no 2021 0.364676265044923 3192 4008346
SGTC_554 4483-2211 187 µM -0.346791869723153 0.395872752914936 no 2022 0.364373842780688 3099 747107
SGTC_1433 4060-0023 7.6 µM -0.349566940039902 0.394819343628277 no 2023 0.363331862704848 3142 3840627
SGTC_3196 9111891 49.47 µM -0.351836599630782 0.393958357784514 no 2024 0.36248040438302 3007 18891510
SGTC_450 aminopyrene 156 nM -0.352363954526073 0.393758381929661 no 2025 0.362282665398392 3144 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1704 st028805 70.8 µM -0.352961958722993 0.393531649371817 no 2026 0.362058479940695 3094 2876101
SGTC_139 0099-0334 718.624 µM -0.353171363100593 0.393452262488108 no 2027 0.361979987632491 2998 97690
SGTC_665 3914-0008 307 µM -0.353184189810508 0.39344739992315 no 2028 0.361975179907945 3018 1069549
SGTC_3174 9107204 49.47 µM -0.354534492272709 0.392935597655939 no 2029 0.361469179702084 3151 3938802
SGTC_2324 6149169 200 µM -0.355081107528426 0.392728467800306 no 2030 0.361264414830745 3085 2888231
SGTC_3347 9188721 44.724 µM -0.355364235262055 0.392621193660626 no 2031 0.361158369352502 3092 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1974 st069448 26.9 µM -0.356441132350748 0.39221324318964 no 2032 0.36075511513193 3171 6323587 YNR016C ACC1
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.35669101237002 0.392118600480628 no 2033 0.360661567320078 3069 6708561
SGTC_192 3455-0609 60.9 µM -0.358267792068746 0.39152153846641 no 2034 0.360071459364507 3159 3769639
SGTC_505 gw-5074 63.9 µM -0.362037139459406 0.39009527842338 no 2035 0.358662138498791 3145 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3120 9124077 49.47 µM -0.362760708767641 0.389821660036391 no 2036 0.358391822593408 3080 18774327 YGL155W CDC43
SGTC_825 1988-2224 89.6 µM -0.362765573512513 0.389819820613329 no 2037 0.358390005429141 3036 1180859
SGTC_3349 9149703 23.001 µM -0.363863853274271 0.389404610046233 no 2038 0.357979838994929 3016 4910494
SGTC_160 3453-0671 289.699 µM -0.364379745415421 0.389209617791805 no 2039 0.357787229108462 3036 5322268
SGTC_3219 9131112 49.47 µM -0.364464526408334 0.389177575705132 no 2040 0.357755579331629 3149 17612988 YMR079W SEC14
SGTC_1357 1503-1303 39.5 µM -0.364745210565442 0.389071499451802 no 2041 0.357650803498016 3066 292895
SGTC_591 4299-0174 154 µM -0.365354812927474 0.388841146803818 no 2042 0.357423283627631 3098 5509088
SGTC_2258 7960471 200 µM -0.365966192958592 0.388610161666607 no 2043 0.357195151173463 3114 2974708
SGTC_1959 st077091 55.8 µM -0.366551698286173 0.388388989149827 no 2044 0.356976721537821 2998 821356 YKL052C ASK1
SGTC_975 1335-0046 28.5 µM -0.368247249729773 0.387748705090171 no 2045 0.356344440814 3060 16486740
SGTC_1518 st038567 90.8 µM -0.370840066192275 0.386770181104119 no 2046 0.355378328621775 3123 77966
SGTC_2261 9010538 184.68 µM -0.37173997802506 0.386430723946743 no 2047 0.355043228253951 3144 6457250
SGTC_1361 1608-0041 5.61 µM -0.372193632522125 0.386259633148166 no 2048 0.354874343306979 3054 X1361
SGTC_2774 tamoxifen 10.92 µM -0.372290954305392 0.386222932188924 no 2049 0.35483811639942 3083 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1490 4089-0339 670 nM -0.37298451739288 0.38596141252624 no 2050 0.354579983591008 3167 742542
SGTC_1003 4049-0218 100 µM -0.37402239667343 0.385570159451936 no 2051 0.354193826688954 3211 295161
SGTC_2987 9018338 71.43 µM -0.374615994019134 0.385346441233891 no 2052 0.353973038185691 3199 5055682
SGTC_3190 9110366 49.47 µM -0.378290307723282 0.383962497319765 no 2053 0.3526074723633 3175 17123768
SGTC_1362 1611-0397 101 µM -0.378602366320264 0.383845027158337 no 2054 0.352491582344296 3084 27816
SGTC_655 k060-0012 42 µM -0.378687034433909 0.383813156853152 no 2055 0.352460141285916 3069 5994525
SGTC_1867 st057372 64 µM -0.379548255578447 0.383489025417128 no 2056 0.352140388656569 3131 688837
SGTC_1745 st081495 74 µM -0.381030048823731 0.382931524762809 no 2057 0.351590475837755 3118 13842402 YBL026W LSM2
SGTC_523 1934-0222 13.7 µM -0.382645324812168 0.382324079584466 no 2058 0.350991379464075 3075 1361595
SGTC_1312 1218-2183 165 µM -0.382801193826674 0.382265478340853 no 2059 0.350933588124896 3130 6744073
SGTC_1793 st048256 72.231 µM -0.383187119771722 0.382120395424369 no 2060 0.350790513735827 3061 672022
SGTC_2357 9067248 200 µM -0.383265363844914 0.382090982787135 no 2061 0.350761508876615 3167 9150235
SGTC_2585 alliin 100 µM -0.383986646370165 0.381819878393145 no 2062 0.350494172446024 3274 87310 A garlic compound which reacts with lipids.
SGTC_2575 plumbagin 510 nM -0.384066328422885 0.381789932301711 no 2063 0.35046464359843 3032 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2446 5162541 200 µM -0.384157260726172 0.381755759007862 no 2064 0.350430946698569 3033 1549321
SGTC_2507 purpurin 79.67 µM -0.38596546882023 0.381076407505183 no 2065 0.349761121450866 3056 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_762 1165-0429 115 µM -0.386799757060123 0.38076308523786 no 2066 0.349452228544846 3201 5967793
SGTC_124 0136-0217 7.121 µM -0.388647634876567 0.380069381566876 no 2067 0.348768412017292 3262 3976905
SGTC_3185 9108267 49.47 µM -0.389270699356905 0.379835566503176 no 2068 0.348537954428395 3174 4910486
SGTC_2514 salinomycin 42.74 µM -0.389835677390316 0.379623587289669 no 2069 0.348329030028466 3251 23682228 A polyether potassium ionophore.
SGTC_2270 7924575 90.91 µM -0.390439456157274 0.379397090064542 no 2070 0.348105808284631 3224 1262135
SGTC_1413 3910-0535 34.4 µM -0.390730006828326 0.379288109719952 no 2071 0.347998408171473 3213 2876951
SGTC_1269 0831-0796 3.05 µM -0.392119154382438 0.378767198089503 no 2072 0.34748508769267 3219 927758
SGTC_2683 piperine 63.03 µM -0.392323177762154 0.378690710587814 no 2073 0.347409720102991 3102 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2019 4016004 108 µM -0.392992305563563 0.378439890765959 no 2074 0.347162582204246 3158 45595336
SGTC_2006 4011487 200 µM -0.393317214252241 0.378318118533961 no 2075 0.347042602773769 3262 45595294
SGTC_2634 4'-methoxyflavone 100 µM -0.395060545009301 0.377664943836174 no 2076 0.346399102975188 3157 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2105 5350118 200 µM -0.396392432407188 0.377166160359798 no 2077 0.345907773963187 3139 2133313
SGTC_2142 5622915 118.518 µM -0.396593008266341 0.377091063687804 no 2078 0.345833804618098 3128 5322196
SGTC_375 3970-0961 9.27 µM -0.397615853038299 0.37670817749991 no 2079 0.345456686487537 3121 2898222
SGTC_478 N-arachidonylglycine 10 µM -0.397654876245656 0.376693572161952 no 2080 0.345442301846328 3168 5283389
SGTC_2483 5729050 27.16 µM -0.397753704154898 0.376656584320536 no 2081 0.345405873137702 3279 2865180
SGTC_1220 1838-0075 193 µM -0.397823345191935 0.376630520788009 no 2082 0.345380203789127 3118 5529645
SGTC_96 0929-0093 37.281 µM -0.399918843680748 0.375846532752559 no 2083 0.344608146323837 3108 6991579
SGTC_1491 4138-0063 26.5 µM -0.400201037195681 0.375740994866139 no 2084 0.344504225370633 3192 23883227
SGTC_2978 9011784 42.97 µM -0.400658026347078 0.375570104671639 no 2085 0.344335958841297 3185 2994934
SGTC_3005 9076496 71.4286 µM -0.400873313044985 0.375489607090471 no 2086 0.344256699480536 3222 21368410
SGTC_715 0868-0130 184 µM -0.401092969658096 0.375407481146328 no 2087 0.344175838353459 3263 2876258
SGTC_3062 9077494 49.47 µM -0.40111614066123 0.375398818223862 no 2088 0.344167308939405 3212 16459633
SGTC_1863 st057641 20.1 µM -0.401734552439971 0.375167636387718 no 2089 0.343939696388975 3179 3921635
SGTC_2240 6690706 185.951 µM -0.401800811053879 0.375142869484861 no 2090 0.343915312605266 3001 805876
SGTC_896 0964-0007 44.5 µM -0.402431601185805 0.37490711132252 no 2091 0.343683208513487 3223 6756758
SGTC_2526 patulin 37.61 µM -0.404178577497493 0.37425442216118 no 2092 0.343040702861633 3254 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1638 st008370 60.6 µM -0.404831836310865 0.374010450072873 no 2093 0.342800562734359 3173 24207134
SGTC_1681 tripelennamine 100 µM -0.405373398328317 0.373808231555452 no 2094 0.342601530860871 3197 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_741 4582-0002 126 µM -0.40564188243448 0.373707992830599 no 2095 0.342502875264703 3088 2912688
SGTC_589 1227-0070 34.1 µM -0.405922432054448 0.373603258564591 no 2096 0.342399797624559 3235 2841384
SGTC_2679 rapamycin 1 nM -0.406272095196552 0.373472736033803 no 2097 0.342271343194868 3189 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2399 5884133 200 µM -0.409180619672525 0.37238760352613 no 2098 0.341203557904552 3123 722445
SGTC_74 000s-0487 160.283 µM -0.409617602571062 0.372224658177692 no 2099 0.341043241129079 3209 677548
SGTC_2182 6325192 200 µM -0.410144121651092 0.372028356317366 no 2100 0.340850114155474 3232 736248
SGTC_1919 st067113 52.3 µM -0.412145108700021 0.371282633018642 no 2101 0.340116533726053 3241 1268243
SGTC_230 MPP+ 141.667 µM -0.412538743153605 0.37113599098868 no 2102 0.339972294786723 3177 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2118 5526350 200 µM -0.414730362916954 0.370319881745184 no 2103 0.339169651253535 3215 743594
SGTC_846 0335-0850 148 µM -0.415505095535669 0.370031528349023 no 2104 0.33888609286918 3207 6819598
SGTC_2782 7736369 71.43 µM -0.416289781551712 0.369739544780764 no 2105 0.338598984492351 3150 2950836 YOL077C BRX1
SGTC_2326 6164455 177.58 µM -0.416434936194025 0.369685540611465 no 2106 0.338545884205414 3181 2888790
SGTC_194 1486-1323 56.904 µM -0.416969090863047 0.369486832771678 no 2107 0.33835050806763 3177 5178754
SGTC_795 0685-0265 78 µM -0.418658988785674 0.368858413262169 no 2108 0.337732686007182 3192 302754
SGTC_1064 honokiol 6.76 µM -0.423935807006521 0.366898394207631 no 2109 0.33580631472181 3216 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2299 7976368 114.88 µM -0.42429707580196 0.366764330837204 no 2110 0.335674585778527 3257 2979718
SGTC_1344 1488-0097 29.1 µM -0.426230853491933 0.366047001222643 no 2111 0.334969818716004 3252 747966
SGTC_3080 9117754 49.47 µM -0.427543387303409 0.365560386777167 no 2112 0.334491795234117 3356 9550191
SGTC_314 1671-0008 2.74 µM -0.429499037619532 0.364835741955405 no 2113 0.333780047045231 3186 3913060
SGTC_1652 st011932 78 µM -0.429527871543476 0.364825061464128 no 2114 0.333769557561859 3234 1551076
SGTC_3160 9100216 49.47 µM -0.431592406442664 0.364060601786512 no 2115 0.333018839206639 3225 17191039
SGTC_1289 0976-0073 69.1 µM -0.432987329875393 0.363544392876321 no 2116 0.332511987260431 3262 3391136
SGTC_3051 9093778 49.47 µM -0.433149990869732 0.363484214240736 no 2117 0.332452903536995 3222 17217378
SGTC_1659 st012954 42.1 µM -0.4335415863259 0.363339352022818 no 2118 0.33231068050366 3258 24207262
SGTC_1235 benzylparaben 21.5 µM -0.433692707917708 0.363283453103338 no 2119 0.332255801309072 3245 7180
SGTC_943 3253-1379 105 µM -0.434120813575789 0.36312511534251 no 2120 0.332100356001202 3311 668464
SGTC_2967 9089538 49.85 µM -0.435428327089649 0.362641667577662 no 2121 0.331625776345418 3346 728216
SGTC_324 1315-0088 19.6 µM -0.437403179847524 0.36191188905806 no 2122 0.330909489218455 3240 6787421
SGTC_1100 amiodarone 5.07 µM -0.437839025272958 0.36175089613418 no 2123 0.33075148954009 3263 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1460 k062-0059 9.15 µM -0.441447763405423 0.360418839953954 no 2124 0.329444435166762 3091 1373085
SGTC_3035 9091303 49.47 µM -0.44176287144962 0.360302607488624 no 2125 0.329330404272641 3231 25237002
SGTC_1208 2323-2347 50.3 µM -0.442901868843217 0.359882578463758 no 2126 0.328918357802087 3306 5412760
SGTC_2705 st078069 42.8 µM -0.443771436412635 0.35956202113325 no 2127 0.328603920786043 3246 1530061
SGTC_1680 diphenhydramine 100 µM -0.443888395334118 0.359518912937013 no 2128 0.328561637505709 3185 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_91 0417-1751 58.384 µM -0.445244387243007 0.359019258139882 no 2129 0.328071576311828 3282 6795624
SGTC_1630 st005209 31.3 µM -0.445322720488121 0.358990401327146 no 2130 0.328043275376793 3320 3367314
SGTC_2993 9054257 71.4286 µM -0.446501129239142 0.358556390098808 no 2131 0.327617648541291 3175 6470217 YGL055W OLE1
SGTC_1279 0874-0590 65.2 µM -0.44803394920628 0.35799212154711 no 2132 0.327064347796291 3236 3523074
SGTC_1842 st055362 61.2 µM -0.448120932372325 0.357960110201103 no 2133 0.327032960934964 3175 676032
SGTC_628 1636-0253 16 µM -0.448240950708856 0.357915942966886 no 2134 0.326989655726152 3241 4456143
SGTC_1788 fluconazole 20 µM -0.44834464289573 0.35787778535332 no 2135 0.326952243220679 3273 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2622 2-methoxyxanthone 59.94 µM -0.449462005399047 0.357466698092721 no 2136 0.32654920531857 3192 71034 A hepatoprotective.
SGTC_2333 9017922 200 µM -0.450742438338983 0.356995819116069 no 2137 0.326087595982102 3301 3163164
SGTC_1342 1486-1464 234 µM -0.451805303227354 0.356605116113225 no 2138 0.325704624455908 3202 3253938
SGTC_1877 wortmannin 25 µM -0.453137110470181 0.356115763804214 no 2139 0.325225007182136 3332 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2340 7987427 183.45 µM -0.458152428919954 0.354275093015821 no 2140 0.323421467043456 3303 2239331
SGTC_2719 novobiocin 32.65 µM -0.458158507509325 0.354272864168131 no 2141 0.323419283648667 3321 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1177 0983-0204 23.6 µM -0.459353220042648 0.353834893687932 no 2142 0.322990267815197 3334 766818
SGTC_2864 9034755 47.6 µM -0.459977350206282 0.353606170240617 no 2143 0.322766239083753 3313 4930451
SGTC_45 0kpi-0036 14.9 µM -0.460243414789034 0.35350868226694 no 2144 0.322670755937389 3332 2795021
SGTC_2727 riluzole 51.77 µM -0.461305230614121 0.35311972107014 no 2145 0.322289816385677 3272 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2355 9061122 103.12 µM -0.461772605378874 0.352948562343055 no 2146 0.322122199018881 3276 5302957
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.462140956391249 0.352813688366331 no 2147 0.321990120610361 3228 688761
SGTC_2962 9082311 13.18 µM -0.46325989524794 0.352404095546029 no 2148 0.321589044323981 3172 16459453
SGTC_365 0121-0052 13.6 µM -0.464944132690555 0.351787895244077 no 2149 0.320985732479295 3322 3101739
SGTC_1850 st056238 17 µM -0.465203994991081 0.35169285583319 no 2150 0.320892689046864 3296 5393177
SGTC_739 1486-1183 203 µM -0.466192903653227 0.35133126716417 no 2151 0.320538714189702 3333 4346692
SGTC_464 bw-b 70c 158 µM -0.467032081660402 0.351024532124555 no 2152 0.320238462621319 3329 5353454
SGTC_2173 5763948 167 µM -0.467187992204033 0.350967554629235 no 2153 0.320182691958388 3293 2867177
SGTC_2050 5263056 171 µM -0.469276745813117 0.350204543401344 no 2154 0.319435917390021 3344 763468 YGL055W OLE1
SGTC_2156 5649887 115 µM -0.470337868415924 0.34981715188298 no 2155 0.319056823212667 3324 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_404 fumagillin 50 µM -0.471724026077311 0.349311333001293 no 2156 0.318561892759546 3298 12015870 A methionine aminopeptidase binder.
SGTC_2726 cimetidine 79.27 µM -0.471810930866925 0.349279629722316 no 2157 0.318530873994767 3267 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2056 5235370 200 µM -0.473446318623341 0.348683228836368 no 2158 0.317947395446656 3205 5511916
SGTC_1694 st024011 44.9 µM -0.474097568874581 0.348445831808063 no 2159 0.317715166086516 3337 2787533
SGTC_1735 st034310 56.75 µM -0.47443959392464 0.348321178874381 no 2160 0.317593232063984 3369 871153
SGTC_3001 9076041 71.4286 µM -0.475987649438779 0.347757186465201 no 2161 0.317041588394394 3251 16004211
SGTC_222 nsc-310342 10.666 µM -0.476251809955871 0.347660980280896 no 2162 0.316947496358952 3318 432556
SGTC_1197 1601-0112 267 µM -0.477965020048045 0.347037274501114 no 2163 0.316337551054044 3220 7350313
SGTC_2485 5633444 17.78 µM -0.479666004437635 0.346418429254906 no 2164 0.315732452319897 3290 5724239
SGTC_3022 9087993 49.47 µM -0.48088330379159 0.345975807758728 no 2165 0.315299719892114 3334 17173644
SGTC_1657 st012939 43.4 µM -0.480885469937891 0.345975020314893 no 2166 0.315298950083801 3359 24207257
SGTC_811 0416-0114 265 µM -0.481488827487164 0.345755711958254 no 2167 0.31508455920384 3352 6612453
SGTC_2417 cerulenin 830 nM -0.481577377378025 0.345723530203355 no 2168 0.315053100033232 3391 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_452 diindolylmethane 8 µM -0.484733491162563 0.344577230828929 no 2169 0.313932703110811 3331 3071 Inhibits expression of several cancer promoting factors.
SGTC_783 0848-0141 92.7 µM -0.485196139093241 0.344409316838973 no 2170 0.313768610268394 3305 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3217 9129673 49.47 µM -0.485388525958054 0.344339500745426 no 2171 0.313700384972248 3397 17248312
SGTC_1866 st057638 64 µM -0.486161993018625 0.344058867517163 no 2172 0.313426158109354 3262 688802
SGTC_248 streptozotocin 5.23457 mM -0.486187946204409 0.344049452539257 no 2173 0.313416958391785 3337 5300 DNA alkylating agent.
SGTC_2353 9059630 146.67 µM -0.488659476783552 0.343153304769061 no 2174 0.31254139877772 3330 4779114
SGTC_466 geldanamycin 89.2 µM -0.490696531318919 0.342415355150983 no 2175 0.311820550090723 3255 5288382 HSP90 inhibitor.
SGTC_2951 9072950 58.06 µM -0.490841435629369 0.342362884543051 no 2176 0.311769300482928 3357 16488155
SGTC_1962 st076595 64.5 µM -0.491067343757954 0.342281088098966 no 2177 0.311689408799129 3274 279619
SGTC_1160 4092-0570 10.5 µM -0.491841871274516 0.342000704635441 no 2178 0.311415566930061 3269 4994975
SGTC_156 3474-0145 5.642 µM -0.492137040437527 0.341893874597717 no 2179 0.311311234392187 3366 2265471
SGTC_1109 tnp00067 928.257 nM -0.492320451194424 0.341827499452269 no 2180 0.311246412388591 3302 676295
SGTC_2013 4024628 200 µM -0.494116269626688 0.341177863155612 no 2181 0.310612034168821 3397 5230760
SGTC_444 curcumin 90.4 µM -0.494520330834936 0.341031759011481 no 2182 0.310469375828534 3368 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1093 fluphenazine 7.97 µM -0.496043142484841 0.340481341194985 no 2183 0.309931986375897 3313 6602611 An atypical antipsychotic.
SGTC_526 4469-0568 170 µM -0.496224571205079 0.340415786693839 no 2184 0.309867988498674 3276 2901964
SGTC_3173 9105693 49.47 µM -0.498883942165241 0.339455447089901 no 2185 0.308930573562891 3445 17096658
SGTC_1137 ixabepilone 100 µM -0.499127983027455 0.339367372280744 no 2186 0.308844612565992 3376 154225 A novel microtubule stabilizer.
SGTC_3285 9112818 20.8695 µM -0.500372866136224 0.338918228236296 no 2187 0.308406277727015 3337 17017947 YPR165W RHO1
SGTC_2844 9010103 25.97 µM -0.500529344196648 0.338861788362544 no 2188 0.30835119965759 3400 2480525
SGTC_3260 9137109 49.47 µM -0.501104567124743 0.338654343030004 no 2189 0.308148766385515 3294 17478346
SGTC_1186 1319-0216 26 µM -0.501649774060405 0.338457767677305 no 2190 0.307956950238625 3429 4565136
SGTC_2614 arthonioic acid 13.39 µM -0.50290831008337 0.338004168351913 no 2191 0.307514369132959 3338 6710684
SGTC_947 3447-0010 211 µM -0.504695520904023 0.337360429085217 no 2192 0.306886353747514 3367 748350
SGTC_1499 4480-0877 67.3 µM -0.506074858598598 0.336863927678427 no 2193 0.306402049633451 3351 2861909
SGTC_332 4112-0506 40.9 µM -0.50607506884293 0.336863852021275 no 2194 0.306401975839566 3313 2790355
SGTC_1353 1498-1206 8.11 µM -0.50639457423665 0.336748884526232 no 2195 0.306289841370051 3413 6756808
SGTC_622 1348-1566 26.3 µM -0.506783995696006 0.336608779788818 no 2196 0.306153193502035 3347 7340407
SGTC_469 w7 172 µM -0.5080305408628 0.336160454538293 no 2197 0.305715962577057 3370 45115570 A P450 inhibitor.
SGTC_1903 st060211 78.3 µM -0.50838827854061 0.336031835655676 no 2198 0.305590535687555 3412 688960
SGTC_2591 skatole 100 µM -0.509694652402783 0.335562312888558 no 2199 0.305132700008097 3385 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2070 5230947 200 µM -0.510142816016116 0.335401297856708 no 2200 0.304975705428965 3423 2835538
SGTC_1007 4101-0031 70 µM -0.510980835471839 0.335100297581776 no 2201 0.304682238171758 3399 1146276
SGTC_2128 5255449 168.493 µM -0.511212445544405 0.3350171264171 no 2202 0.304601152456101 3299 736008
SGTC_2400 5203494 178.7 µM -0.51316227372939 0.334317264287506 no 2203 0.303918906698264 3370 6777674
SGTC_253 dyclonine 31.25 µM -0.513162480376744 0.334317190144939 no 2204 0.303918834428388 3387 3180 An oral anasthetic.
SGTC_3189 9110682 49.47 µM -0.51358739593785 0.334164749265066 no 2205 0.303770246778787 3370 17122418
SGTC_870 0573-2213 57.6 µM -0.513875293614769 0.334061479874292 no 2206 0.30366959099191 3403 3916321
SGTC_2099 5377090 177.372 µM -0.513964922239149 0.334029332496846 no 2207 0.303638257759728 3367 2243829
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.515274517492469 0.33355975488811 no 2208 0.303180601632708 3363 16486 A toxic proline analog.
SGTC_1065 prochlorperazine maleate 2.48 µM -0.515396995094374 0.333515851781802 no 2209 0.303137815922758 3412 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1159 4092-0538 61.2 µM -0.515865979653415 0.333347761484965 no 2210 0.302974008188265 3374 717301
SGTC_2093 5331342 194.4 µM -0.518412465263519 0.332435652052689 no 2211 0.302085259703139 3416 33839
SGTC_18 0111-0177 500 nM -0.521536802688168 0.331317920111696 no 2212 0.300996437464948 3422 721752
SGTC_1131 3454-3128 32.3 µM -0.522005503180491 0.33115037171241 no 2213 0.300833249475224 3405 710982
SGTC_3342 9147791 14.508 µM -0.522316845628098 0.331039093458117 no 2214 0.300724871082293 3360 1838168
SGTC_820 1582-0060 59.9 µM -0.522341953846825 0.33103012007093 no 2215 0.300716131672153 3304 3848840
SGTC_691 1548-0686 185 µM -0.523290361064591 0.330691241405737 no 2216 0.300386103824759 3333 46495133
SGTC_2830 7992007 71.43 µM -0.523733328393298 0.330533010728401 no 2217 0.30023201562683 3326 1952075
SGTC_836 0330-0104 1.35 µM -0.524399398732326 0.330295143287652 no 2218 0.300000387321242 3383 46494820
SGTC_951 1171-0579 82.7 µM -0.524501878134261 0.33025855186541 no 2219 0.299964756926729 3391 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3229 9132204 49.47 µM -0.525361976692836 0.329951508019692 no 2220 0.299665790385187 3341 17682924
SGTC_2287 7945887 168.79 µM -0.525438084326809 0.329924344110232 no 2221 0.299639342202579 3365 1245853
SGTC_266 formosanin C 406 nM -0.525528807113467 0.329891965014194 no 2222 0.299607816486466 3378 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2305 7443522 69.23 µM -0.525575024078804 0.329875470601272 no 2223 0.299591756899267 3371 5415886
SGTC_2373 9071805 200 µM -0.526390710834864 0.329584413908903 no 2224 0.299308384236146 3433 10149009
SGTC_558 k064-0027 21.3 µM -0.527963400704122 0.329023531668325 no 2225 0.298762369320629 3374 5088526
SGTC_2565 isoliquiritigenin 100 µM -0.528377096297244 0.32887605562457 no 2226 0.298618815506391 3382 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1303 1160-0052 261 µM -0.530291098095267 0.328194090781135 no 2227 0.29795505886716 3413 3562476
SGTC_1053 3366-3204 134 µM -0.530739972542396 0.328034238158909 no 2228 0.297799491119188 3342 3632071 YPR165W RHO1
SGTC_3301 9125354 19.7965 µM -0.532226609211896 0.327505043924128 no 2229 0.29728452776812 3407 41905162
SGTC_730 1436-0052 41.2 µM -0.53295517697788 0.327245823933636 no 2230 0.297032304277047 3418 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1348 1493-0373 93.8 µM -0.533370507394643 0.327098089159143 no 2231 0.296888564502736 3363 3010129
SGTC_1057 3448-5381 134 µM -0.533494028772412 0.327054157311027 no 2232 0.296845821704689 3398 5497911
SGTC_3234 9132280 49.47 µM -0.534222491572859 0.326795119603052 no 2233 0.29659380492002 3416 17612295
SGTC_1164 k060-0068 93.7 µM -0.535100549902713 0.326482997406691 no 2234 0.296290164856204 3425 5963676
SGTC_2949 9072542 2.23 µM -0.535218695481687 0.326441009623839 no 2235 0.296249319989976 3405 16457352
SGTC_1216 1165-0504 9.65 µM -0.536964584253232 0.325820794425291 no 2236 0.295646038874588 3445 6304004
SGTC_659 k018-0002 107 µM -0.537802448118333 0.325523319896095 no 2237 0.295356720836919 3438 6797879 YHR007C ERG11
SGTC_2164 5685496 200 µM -0.53922542512948 0.325018361893443 no 2238 0.294865659412961 3448 759046
SGTC_145 3737-0113 38.366 µM -0.539731445007945 0.324838872927605 no 2239 0.294691125525146 3464 6849351
SGTC_1979 st071809 45.3 µM -0.543754681717893 0.323413250884733 no 2240 0.293305149022391 3469 4976333
SGTC_3275 9138069 49.47 µM -0.544170016891333 0.323266225154438 no 2241 0.293162241205666 3416 17617007
SGTC_3323 9138564 53.9225 µM -0.544996058933664 0.322973894127605 no 2242 0.292878114076719 3483 43912313 YNL103W MET4
SGTC_1503 4585-0012 61.3 µM -0.545857584765843 0.322669122079244 no 2243 0.292581918112454 3474 2922052
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.546716877033515 0.322365258796244 no 2244 0.292286628774654 3497 688664
SGTC_968 1309-0633 340 µM -0.55035778812545 0.321079076708974 no 2245 0.291036997623938 3429 3761976
SGTC_310 1273-0058 1.06 µM -0.550540244918365 0.321014678609394 no 2246 0.290974440645292 3462 2734232
SGTC_3050 9093513 49.47 µM -0.550929900918266 0.320877167605202 no 2247 0.290840864565651 3452 25236664
SGTC_2729 fluphenazine 10.66 µM -0.550950704443561 0.320869826656999 no 2248 0.29083373381638 3349 3372 An atypical antipsychotic.
SGTC_3052 9092717 49.47 µM -0.551346954129358 0.320730015247118 no 2249 0.290697928348507 3465 25237534
SGTC_1415 3966-0071 78.1 µM -0.551581874296421 0.320647138806971 no 2250 0.290617428869944 3445 2893185
SGTC_3277 9138724 49.47 µM -0.555381197998163 0.319308036168502 no 2251 0.289316975146209 3352 15943418
SGTC_142 0335-0849 62.6745 µM -0.556619744277019 0.318872008256309 no 2252 0.288893630431409 3502 3889043 YPR107C YTH1
SGTC_2385 9074692 200 µM -0.556986511740943 0.318742936513946 no 2253 0.28876832244036 3398 17046906
SGTC_2183 6420625 130.508 µM -0.559106777964271 0.317997209882024 no 2254 0.288044424623333 3481 2897619
SGTC_3146 9095609 49.47 µM -0.559226428648943 0.317955149051712 no 2255 0.288003599226552 3403 17173999
SGTC_35 0133-0054 64.071 µM -0.559914558779781 0.317713296123699 no 2256 0.287768858914451 3395 99677
SGTC_1655 st012546 55.1 µM -0.559946993788838 0.317701898305792 no 2257 0.287757796662412 3428 720985 YLR208W SEC13
SGTC_1166 k206-0078 225 µM -0.560658070477096 0.317452065969432 no 2258 0.287515328049117 3453 5404595
SGTC_3078 9116413 49.47 µM -0.560968336911102 0.317343081846359 no 2259 0.287409561200289 3377 17177322
SGTC_2725 haloperidol 53.21 µM -0.564725383364191 0.316024641570317 no 2260 0.286130283141917 3420 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2723 salbutamol 83.58 µM -0.565121245643483 0.315885859508901 no 2261 0.28599564932067 3454 9884233 β2-adrenoceptor agonist
SGTC_1000 4048-0884 8.67 µM -0.565925499057406 0.315603982924639 no 2262 0.285722213340831 3475 13040088
SGTC_2909 7941780 10.49 µM -0.566231072504722 0.315496912945935 no 2263 0.285618354848932 3503 1243215
SGTC_86 0417-1630 471.922 µM -0.566686984748256 0.315337194502909 no 2264 0.285463432519954 3478 3634867
SGTC_339 3091-4833 71.4 µM -0.567589581388515 0.315021092173229 no 2265 0.285156841617755 3460 3240077
SGTC_485 niflumic acid 177 µM -0.567821506962251 0.314939890361797 no 2266 0.28507808729328 3479 4488 A COX2 inhibitor.
SGTC_2396 5342950 42.78 µM -0.568302963917841 0.31477135115147 no 2267 0.284914633402116 3431 1886677
SGTC_1663 st014140 55.4 µM -0.569106967667447 0.314489986959313 no 2268 0.284641775074951 3529 4207120
SGTC_1 0258-0098 57.368 µM -0.569777170459538 0.314255529231552 no 2269 0.284414420759757 3392 6790032 YDR047W HEM12
SGTC_440 fluspirilene 35.1 µM -0.570656461060932 0.313948039740179 no 2270 0.284116268801326 3566 3396 An atypical antipsychotic.
SGTC_1945 st075991 56.6 µM -0.571890364280345 0.313516759380447 no 2271 0.283698126193626 3402 1084980
SGTC_90 0870-0863 4.608 µM -0.572015233645198 0.313473128570099 no 2272 0.28365582714588 3439 1738164
SGTC_1432 4049-0298 68.4 µM -0.572342215658837 0.313358889612465 no 2273 0.283545077481051 3481 741646
SGTC_2354 9060492 162 µM -0.572657556970164 0.313248734571271 no 2274 0.28343829018332 3483 6471895
SGTC_815 1582-0027 36.9 µM -0.573481477718615 0.312961001192091 no 2275 0.283159368382659 3487 3128206
SGTC_126 0417-1624 672.48 µM -0.573734354923229 0.312872713089172 no 2276 0.283073788310187 3566 41912 YDL195W SEC31
SGTC_3100 9120536 49.47 µM -0.573989654908542 0.312783589996892 no 2277 0.282987400901591 3406 16421196
SGTC_2964 9083345 53.42 µM -0.575218236811285 0.312354855429889 no 2278 0.282571855268164 3397 17741579
SGTC_178 4092-0806 87.505 µM -0.575291569255585 0.312329272850001 no 2279 0.282547061173675 3483 2169044
SGTC_3244 9134489 49.47 µM -0.577214045127366 0.311658925581926 no 2280 0.2818974351391 3455 16584271
SGTC_1108 betulinic acid 729.144 nM -0.577712934317287 0.311485069961257 no 2281 0.281728972596545 3446 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_115 0527-0192 112.043 µM -0.577813705207578 0.311449957873393 no 2282 0.281694950651231 3493 4233931
SGTC_2733 amorolfine 100 µM -0.578217285401215 0.311309353667251 no 2283 0.281558715054089 3473 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_880 0833-0487 87.2 µM -0.578276338656352 0.311288782279459 no 2284 0.281538783254112 3466 76075
SGTC_2810 7959871 45.46 µM -0.579066567142536 0.31101356042082 no 2285 0.281272128903973 3437 2974535
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.579493134923717 0.310865038711951 no 2286 0.28112823875309 3475 442882
SGTC_2184 6075246 200 µM -0.579628806701058 0.310817807179098 no 2287 0.281082481305207 3460 2267320
SGTC_1446 4239-0190 62 µM -0.580349064883168 0.31056711529003 no 2288 0.28083962313685 3401 1340085
SGTC_3228 9131799 49.47 µM -0.580456872063521 0.310529599662943 no 2289 0.280803281215686 3439 17015818
SGTC_3344 9148862 3.898 µM -0.581862344139439 0.310040692382017 no 2290 0.280329703187327 3539 4905352
SGTC_707 0865-0008 204 µM -0.582075801556486 0.309966468461 no 2291 0.280257811918265 3474 723043
SGTC_3226 9131256 49.47 µM -0.582578491588497 0.30979170248455 no 2292 0.280088544004434 3424 17178073
SGTC_61 0978-8327 98.565 µM -0.583625943797012 0.30942768179192 no 2293 0.279736000734992 3506 6150059 YHR072W ERG7
SGTC_2170 morpholine 200 µM -0.584929449299526 0.308974936050789 no 2294 0.279297577970089 3495 121171 Reacts with secondary amines.
SGTC_355 1311-2252 105 µM -0.585993614590276 0.308605535200149 no 2295 0.278939902939142 3426 5338538
SGTC_2453 5731132 22.18 µM -0.58614031513645 0.308554626609074 no 2296 0.27889061311609 3537 1362040
SGTC_491 tetrandrine 80.3 µM -0.586925425724111 0.308282237062772 no 2297 0.278626896361008 3492 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_9 0092-0002 10.449 µM -0.587171569351574 0.308196860686354 no 2298 0.278544242320261 3501 759368
SGTC_516 3992-2719 87.3 µM -0.587559150535012 0.308062446888383 no 2299 0.278414118330648 3361 5350887 YDR037W KRS1
SGTC_359 0081-0058 15.9 µM -0.588369640653883 0.307781450780406 no 2300 0.278142105419304 3644 3494159
SGTC_824 1304-0008 100 µM -0.589080436287001 0.307535111399842 no 2301 0.277903658238844 3479 768245
SGTC_2284 7945075 39.21 µM -0.589100473766767 0.307528168297446 no 2302 0.277896937808493 3517 1245402
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.592141152913753 0.30647535576447 no 2303 0.276878035746799 3475 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2332 7982454 138.89 µM -0.592838629389172 0.306234084350545 no 2304 0.276644576365938 3502 2981748
SGTC_2925 9010536 32.5 µM -0.593017493877706 0.306172224986414 no 2305 0.276584722376046 3471 2994177
SGTC_289 k017-0060 526 µM -0.593279297733277 0.306081691432204 no 2306 0.276497125570076 3453 5512909
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.593568075329832 0.305981843911277 no 2307 0.276400519414797 3531 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2929 9013348 24.6 µM -0.593897472209231 0.305867969497773 no 2308 0.276290344911253 3475 2995952
SGTC_956 1185-0240 191 µM -0.594190980395399 0.305766517822869 no 2309 0.276192192378678 3485 1416193
SGTC_3158 9100007 49.47 µM -0.59505289019064 0.305468683200585 no 2310 0.275904058726338 3448 19297233
SGTC_1756 st041558 35.5 µM -0.595190155329664 0.305421262837499 no 2311 0.275858185069385 3594 3955792
SGTC_3348 9149464 3.537 µM -0.59585496504193 0.305191640256868 no 2312 0.275636060411162 3521 1951442
SGTC_1524 corynanthine 62.1 µM -0.596761861520266 0.304878525503059 no 2313 0.27533319216188 3541 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1066 ketoconazole 628 nM -0.596936494046084 0.304818248332944 no 2314 0.275274890481896 3548 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_303 1348-1668 34.2 µM -0.598932835445508 0.304129556346249 no 2315 0.274608837038609 3495 5380509
SGTC_3293 9120939 62.045 µM -0.599217231600363 0.30403150264419 no 2316 0.274514016674793 3523 934087
SGTC_1298 1079-1278 263 µM -0.599303036898816 0.304001921582813 no 2317 0.274485411550568 3518 2840950
SGTC_2828 7998861 71.43 µM -0.600157091431398 0.303707559393571 no 2318 0.274200773487333 3466 2988188
SGTC_144 4161-2749 112.381 µM -0.60031934552618 0.30365165056636 no 2319 0.274146714159914 3456 797501 YMR168C CEP3
SGTC_369 0957-0393 4.5 µM -0.60052093762638 0.303582193217223 no 2320 0.274079555650164 3473 6997992
SGTC_1184 1269-1718 139 µM -0.601214267152514 0.303343364861713 no 2321 0.273848641520338 3526 5403821
SGTC_1048 3161-0300 24.5 µM -0.601477837204892 0.303252596008254 no 2322 0.273760884477992 3531 2165101
SGTC_2895 9054447 58.44 µM -0.601751873722183 0.303158235567333 no 2323 0.273669657321625 3512 2697450
SGTC_2323 6148992 148.28 µM -0.603811666424742 0.30244939697655 no 2324 0.272984431089252 3442 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_299 1273-0059 1.44 µM -0.603853153426846 0.302435127649375 no 2325 0.272970638452887 3518 2848077
SGTC_2555 cholic acid 100 µM -0.604947284565362 0.302058913621156 no 2326 0.272607011870231 3548 6708657 Influences liver metabolism.
SGTC_909 3448-9333 149 µM -0.605508224607392 0.301866117431749 no 2327 0.272420680776723 3490 3344074
SGTC_2655 perillic acid 100 µM -0.605657184638548 0.301814928871367 no 2328 0.272371210388007 3470 5702197 An apoptosis inducer.
SGTC_3256 9138902 49.47 µM -0.60814367744117 0.300961048333856 no 2329 0.271546092953517 3526 17228773
SGTC_3255 9139072 49.47 µM -0.609235012005971 0.300586620000705 no 2330 0.271184338139127 3540 17646060
SGTC_3123 9126162 49.47 µM -0.612073590826725 0.299613712283504 no 2331 0.270244534734837 3561 25239884
SGTC_181 1447-1644 8.07 µM -0.612427691067842 0.299492446481529 no 2332 0.270127412740302 3510 534600
SGTC_213 1246-0773 967 nM -0.612525257848433 0.299459037497469 no 2333 0.270095146069837 3488 6251622
SGTC_1717 st033143 58.0435 µM -0.613311868260477 0.299189746760193 no 2334 0.269835073692952 3579 674616
SGTC_1408 3909-7976 48.8 µM -0.613613890665038 0.299086380645031 no 2335 0.269735251122548 3535 24152374
SGTC_3312 9133330 71.43 µM -0.614609944992011 0.298745599481693 no 2336 0.269406172558589 3572 17617324
SGTC_2279 7948423 32.93 µM -0.615430070381547 0.298465141638067 no 2337 0.269135368944456 3579 1247112
SGTC_2824 7998404 51.95 µM -0.616266707150575 0.298179160911218 no 2338 0.268859254112139 3507 837851
SGTC_2371 9071574 200 µM -0.616516756117843 0.298093712942778 no 2339 0.268776758191153 3524 45596039
SGTC_1889 st059080 5.18 µM -0.61688854104505 0.297966685390936 no 2340 0.268654122767418 3567 176925 Isolated from Daphnopsis sellowiana.
SGTC_202 3594-0513 34.79 µM -0.616888589913717 0.297966668695627 no 2341 0.268654106649652 3504 708429
SGTC_2704 st078022 71.1 µM -0.619075288135364 0.297220040599458 no 2342 0.267933381016034 3582 54697681
SGTC_611 3453-1652 23.7 µM -0.619946246567295 0.296922898115683 no 2343 0.267646588531718 3554 1560575
SGTC_1016 4226-1401 38 µM -0.620058325913531 0.296884670187483 no 2344 0.267609693860913 3547 2901613
SGTC_1943 st076331 65.2 µM -0.620282203360491 0.29680831700141 no 2345 0.267536004776689 3599 24208415
SGTC_1679 SEC14.276 6.7 µM -0.62227044220582 0.296130624804322 no 2346 0.266882026748691 3532 1005053 YMR079W SEC14
SGTC_1909 st060837 51.5 µM -0.622348577398734 0.296104006890056 no 2347 0.266856342768145 3495 678937
SGTC_1438 4092-1045 4 µM -0.622480622511649 0.296059026256357 no 2348 0.266812940785291 3535 1351342
SGTC_1852 st056254 31.4 µM -0.622687769556641 0.295988468772748 no 2349 0.266744860693777 3493 442583
SGTC_23 0213-0011 39.996 µM -0.622984916163172 0.295887269529533 no 2350 0.266647217051179 3590 627608
SGTC_997 3996-0078 137 µM -0.624378694726699 0.295412802460702 no 2351 0.266189456767448 3549 735687
SGTC_796 1234-0020 70.7 µM -0.625026291783075 0.295192468032968 no 2352 0.265976901182591 3533 46495034
SGTC_2596 sinensetin 100 µM -0.625394862758268 0.295067101510678 no 2353 0.265855966494848 3491 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2427 5545055 42.75 µM -0.625500116942661 0.295031304628572 no 2354 0.265821435842146 3555 5372858
SGTC_508 roscovitine 141 µM -0.629135664674062 0.293796086978823 no 2355 0.264630121666558 3579 160355 A CDKinase inhibitor.
SGTC_448 monastrol 171 µM -0.629940464598408 0.293522971078467 no 2356 0.264366768474077 3519 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2582 agaric acid 100 µM -0.630127894846064 0.293459381867166 no 2357 0.264305455179556 3530 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2034 5197015 53.07 µM -0.630349617858118 0.293384166435644 no 2358 0.264232933182032 3585 780676
SGTC_931 2812-0076 566 µM -0.63134501164903 0.293046607613224 no 2359 0.26390748094837 3568 3450959
SGTC_1153 4055-0057 267 µM -0.63169998358497 0.292926272812659 no 2360 0.263791469385761 3538 882706
SGTC_1879 gemcitabine 100 µM -0.632458382266418 0.292669253989758 no 2361 0.263543697472594 3554 60750 A nucleoside analog which inhibits DNA replication.
SGTC_506 n9-isopropylolomoucine 153 µM -0.633426233183421 0.29234140471709 no 2362 0.263227669248927 3582 6610355
SGTC_2641 levomentholum 100 µM -0.634383904978372 0.292017171716672 no 2363 0.262915155410579 3529 16666
SGTC_2296 7971656 126.45 µM -0.635034897221566 0.291796864936719 no 2364 0.262702827639383 3556 666570
SGTC_568 1193-0097 7.48 µM -0.635080069580535 0.2917815807204 no 2365 0.262688097468438 3500 3646150
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.63672167176054 0.291226392493567 no 2366 0.262153077310697 3579 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.636839230193617 0.291186653278289 no 2367 0.262114784877584 3635 5393153
SGTC_2175 5807670 165.306 µM -0.63706376101673 0.291110760369006 no 2368 0.262041656180978 3542 241186
SGTC_2001 4023502 57.655 µM -0.641662884628197 0.289558262590449 no 2369 0.26054604643198 3574 108941 YCR052W RSC6
SGTC_2607 solasodine 47.35 µM -0.642206251477002 0.289375098678465 no 2370 0.2603696372573 3577 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1707 st032323 6.317 µM -0.644368536828559 0.288646752267739 no 2371 0.259668241007227 3535 3132057 YMR211W DML1
SGTC_2097 5376186 200 µM -0.6445313018769 0.288591961285337 no 2372 0.259615483221583 3562 742755
SGTC_2779 methotrexate 400 µM -0.644732001103955 0.288524407410239 no 2373 0.259550437275219 3642 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_510 ag-490 170 µM -0.645053841570749 0.288416093847632 no 2374 0.259446147429341 3677 5328779
SGTC_398 bronopol 33.3 µM -0.645140203147908 0.288387032616336 no 2375 0.259418166330228 3525 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2942 9052777 62.25 µM -0.64551337616278 0.288261473347425 no 2376 0.259297276421087 3659 6469503
SGTC_1936 st074407 74.3 µM -0.645555916676126 0.288247161635251 no 2377 0.259283497212197 3592 809813
SGTC_1041 0206-0046 107 µM -0.645870025934709 0.288141497654963 no 2378 0.259181766451091 3535 50494
SGTC_1574 spiramycin 23.7 µM -0.646207276015294 0.288028069625881 no 2379 0.259072564030594 3595 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3046 9092212 49.47 µM -0.646601047391521 0.287895658346733 no 2380 0.258945089986212 3596 25236637
SGTC_1555 citronellol 128 µM -0.646642075170466 0.287881863820654 no 2381 0.258931810092804 3556 8842 A terpine precursor.
SGTC_364 0083-0097 67.7 µM -0.647293311334017 0.28766294436949 no 2382 0.258721064811773 3603 5207356
SGTC_325 2810-4341 181 µM -0.647391484399705 0.287629949351788 no 2383 0.258689302917623 3598 774970
SGTC_1887 st057648 70.8 µM -0.647724857483046 0.287517919235793 no 2384 0.258581461919258 3593 688672
SGTC_1587 estradiol valerate 56.1 µM -0.64868321565395 0.287195977669505 no 2385 0.258271577685021 3616 13791 A steroid.
SGTC_3041 9091929 49.47 µM -0.648993196195811 0.287091882340853 no 2386 0.258171386973691 3649 25236887
SGTC_2291 7917025 104.35 µM -0.650092443381207 0.286722885521081 no 2387 0.257816255045941 3561 2964612
SGTC_1988 st071872 53.4 µM -0.650430667005063 0.286609395398365 no 2388 0.257707036737965 3618 16414116
SGTC_1905 st060207 84.5 µM -0.651526466613002 0.286241848885968 no 2389 0.257353348973704 3536 1948547
SGTC_782 0083-0095 30.5 µM -0.6515745667817 0.286225720546157 no 2390 0.257337829616243 3615 3591729 An indicator and reagent.
SGTC_1043 0916-0009 19.3 µM -0.651761869436779 0.286162920702979 no 2391 0.25727740168006 3629 3101130
SGTC_3082 9117008 49.47 µM -0.651908449882051 0.286113778987282 no 2392 0.257230116765156 3571 41448529
SGTC_2264 7948757 110.76 µM -0.652578415117433 0.285889221356313 no 2393 0.257014052360708 3591 2971411
SGTC_3254 9136651 49.47 µM -0.652726736861405 0.285839518496891 no 2394 0.256966231228715 3585 16454030
SGTC_2043 5101342 149 µM -0.653631090568967 0.285536557027371 no 2395 0.256674754358877 3574 678451
SGTC_1130 3454-2858 15.9 µM -0.655289013743547 0.284981544603714 no 2396 0.256140846422767 3557 715628 YIL048W NEO1
SGTC_1884 5633444 25 µM -0.656776647734424 0.284483977149198 no 2397 0.255662270872593 3630 5724239
SGTC_1964 st076914 61 µM -0.658005692637151 0.284073213032196 no 2398 0.255267236610498 3624 24208661
SGTC_2734 clemastine 41.6 µM -0.658754911228802 0.283822952890092 no 2399 0.255026582680071 3578 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2521 angolensin 13.4 µM -0.6603311223794 0.283296798781332 no 2400 0.254520681095716 3618 821428 A flavenoid.
SGTC_2338 7999974 200 µM -0.660834438207791 0.283128885811028 no 2401 0.254359247397898 3662 315925
SGTC_1453 4237-0541 195 µM -0.661521577572206 0.282899723954523 no 2402 0.254138940754891 3583 739892
SGTC_2643 anethole 100 µM -0.661566475912587 0.282884753401234 no 2403 0.254124549193092 3599 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_688 0527-0193 473 µM -0.661573322504692 0.282882470560263 no 2404 0.254122354647235 3611 4007154
SGTC_2202 7226349 200 µM -0.663217689999347 0.282334449871498 no 2405 0.253595571705862 3569 844334
SGTC_530 4358-1714 28 µM -0.665231367387489 0.281664045277 no 2406 0.252951260314673 3614 1564641
SGTC_2242 6630449 61.2675 µM -0.665461710211337 0.281587407221112 no 2407 0.252877613035846 3602 691249 YDR170C SEC7
SGTC_3114 9122766 49.47 µM -0.666884614416836 0.281114211548273 no 2408 0.252422919631186 3570 17176985
SGTC_3017 9080681 49.47 µM -0.666975627933818 0.281083957510147 no 2409 0.252393850651743 3611 16451914
SGTC_1765 st044815 90.4 µM -0.667243416303076 0.280994950410681 no 2410 0.252308331451968 3607 645695
SGTC_76 0433-0009 400.328 µM -0.667407535173114 0.280940407557198 no 2411 0.252255927039067 3610 2841569
SGTC_1302 1159-0335 255 µM -0.667607769430194 0.280873869137206 no 2412 0.252191998479734 3624 649284
SGTC_1376 2910-0861 41.3 µM -0.668110248578183 0.280706927424248 no 2413 0.252031610175657 3634 1112859
SGTC_758 0868-0029 16 µM -0.668526287154559 0.280568740718906 no 2414 0.251898853918108 3630 762687
SGTC_1928 4'-methoxychalcone 40.3 µM -0.669093623646449 0.280380353663948 no 2415 0.251717878597998 3662 641818
SGTC_2181 6316240 54.2555 µM -0.669505296281728 0.280243693964934 no 2416 0.251586601671029 3608 12779990
SGTC_295 k015-0027 31 µM -0.670092763424655 0.280048733051885 no 2417 0.251399328865625 3601 3887424
SGTC_1983 st071813 46.9 µM -0.671447978439848 0.279599232941736 no 2418 0.250967594552571 3627 11838595
SGTC_1023 4482-3888 16 µM -0.671462338008325 0.279594472010471 no 2419 0.250963022089775 3635 3303168
SGTC_3334 9142812 21.919 µM -0.67247609048603 0.279258460719982 no 2420 0.250640328194772 3642 45283678
SGTC_914 3820-6779 408 µM -0.674738790639793 0.278509190578131 no 2421 0.249920867428497 3614 2893481
SGTC_1355 1499-0035 1.68 µM -0.674838710102587 0.278476125855993 no 2422 0.249889121768367 3644 1548538
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.675016104018755 0.278417428485653 no 2423 0.249832766781281 3607 140250 A respiratory chain inhibitor.
SGTC_424 splitomicin 100 mM -0.675471469787809 0.278266781403822 no 2424 0.249688135826261 3607 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_949 1165-0505 146 µM -0.675644304769193 0.278209613410938 no 2425 0.249633252504406 3650 6244267
SGTC_821 1114-0266 29.2 µM -0.677860571636717 0.277477054945234 no 2426 0.248930050713782 3644 3123235
SGTC_285 1486-1325 46 µM -0.678140937379886 0.27738445088138 no 2427 0.24884116833314 3642 22310230
SGTC_664 1222-0054 14.9 µM -0.678473033946259 0.277274779816498 no 2428 0.248735907955237 3635 6813991
SGTC_1912 st060209 90.8 µM -0.679158037461606 0.277048632306613 no 2429 0.248518866112063 3627 688787
SGTC_1316 1272-0050 65.9 µM -0.681266272075677 0.276353185361456 no 2430 0.24785151035008 3640 7340392
SGTC_2772 vinpocetine 57.06 µM -0.684281433189188 0.275360059554637 no 2431 0.246898734432106 3677 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_7 0192-1582 4.227 µM -0.684380280198899 0.275327531342888 no 2432 0.24686753248799 3689 252616
SGTC_1421 4029-0249 71.4 µM -0.685217391407123 0.275052133699543 no 2433 0.24660337547951 3726 2894095
SGTC_676 falcarinol 140 µM -0.686003694318412 0.274793574905399 no 2434 0.24635538939186 3684 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1378 2093-0007 380 nM -0.686644766087647 0.274582860952328 no 2435 0.246153305604887 3670 3618014
SGTC_482 fipronil 114 µM -0.686665751564651 0.274575964581025 no 2436 0.246146691897502 3682 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1878 temozolomide 1 mM -0.686767557538299 0.274542509713914 no 2437 0.24611460844601 3619 5394 DNA alkylating agent.
SGTC_2529 gangaleoidin 93.61 µM -0.688167360330441 0.274082718965797 no 2438 0.245673697766951 3699 4565183
SGTC_627 1391-0720 175 µM -0.688844353806344 0.273860484694528 no 2439 0.24546061025507 3630 997839
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.69083375626764 0.273207946556447 no 2440 0.244835009734489 3681 66535 A nucleotide analog.
SGTC_1084 voriconazole 435 nM -0.691854612712521 0.272873397718965 no 2441 0.244514318023667 3671 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_559 1550-0661 158 µM -0.692561693949361 0.272641796536896 no 2442 0.24429232833018 3684 5830875
SGTC_555 4296-0685 37 µM -0.69266685968261 0.272607358324695 no 2443 0.244259320602175 3640 2908540 YHR072W ERG7
SGTC_2359 9039622 200 µM -0.693863038864076 0.272215802216988 no 2444 0.24388405237924 3641 6463596
SGTC_1980 st071811 45.7 µM -0.694820285639717 0.271902659472793 no 2445 0.243583966860336 3706 4974850
SGTC_3318 9139014 38.6185 µM -0.695157127961807 0.271792511373672 no 2446 0.243478418235363 3659 16643984
SGTC_1473 k844-0725 134 µM -0.695203067323799 0.271777490833212 no 2447 0.24346402517614 3742 54682906
SGTC_1310 1188-0297 994 nM -0.69543183888504 0.271702696805984 no 2448 0.243392356610108 3627 1588352
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.695568424263436 0.27165804679426 no 2449 0.243349573168401 3663 616764
SGTC_2973 9094665 17.96 µM -0.695968231939753 0.271527369928535 no 2450 0.243224362420299 3689 25237061 YIL048W NEO1
SGTC_518 1021-0119 62.6 µM -0.696234315999628 0.271440417890442 no 2451 0.243141050199483 3639 1097762
SGTC_1258 0671-0043 57.1 µM -0.697289151272087 0.271095851060976 no 2452 0.242810928002409 3664 4298767
SGTC_550 4123-0385 25.7 µM -0.700002935972778 0.270210384422247 no 2453 0.241962735454967 3690 5731123
SGTC_269 exalamide 29 µM -0.700845049220689 0.269935910025079 no 2454 0.241699860340111 3652 3316 A derivative of salicylamide.
SGTC_12 0849-0099 9.267 µM -0.701369933228146 0.269764902445432 no 2455 0.24153609035659 3617 6071388
SGTC_2366 9070441 60.58 µM -0.702547819124997 0.269381343972367 no 2456 0.241168795553669 3683 6837235
SGTC_3315 9136395 68.55 µM -0.703413143384193 0.269099740193276 no 2457 0.240899158994435 3707 16876844
SGTC_1616 st002734 56.1 µM -0.704433618194263 0.268767835469316 no 2458 0.240581388095375 3655 4026101
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.704498967222525 0.268746588007166 no 2459 0.240561046503351 3615 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2882 9058044 58.44 µM -0.70473113474844 0.268671108312033 no 2460 0.240488785870318 3632 18076804
SGTC_1126 isoteolin 1.0172 µM -0.705243377259032 0.268504611473202 no 2461 0.240329395538308 3667 133323
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.705739610555706 0.268343367670768 no 2462 0.240175041562348 3696 688669
SGTC_1871 st057448 67.3 µM -0.707495702046261 0.267773142662759 no 2463 0.239629241337147 3767 691747
SGTC_470 aa-861 153 µM -0.70791502102809 0.267637074861795 no 2464 0.23949901552668 3676 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_223 busulfan 5 mM -0.708102400402804 0.267576282063429 no 2465 0.239440834540562 3668 2478 A DNA alkylator.
SGTC_2189 6047310 154.431 µM -0.708110684635277 0.267573594512771 no 2466 0.239438262478245 3635 711535
SGTC_998 3996-0085 177 µM -0.70831066135265 0.26750872267949 no 2467 0.239376178917355 3722 715391
SGTC_892 0929-0076 29 µM -0.70831436475026 0.267507521383473 no 2468 0.239375029265882 3692 5751038
SGTC_804 1595-0054 20.9 µM -0.708560896399447 0.267427558370891 no 2469 0.239298504845786 3674 761523 Stimulates phospholipase C.
SGTC_3043 9092303 49.47 µM -0.709127749086414 0.267243744356073 no 2470 0.239122602184386 3680 25236084
SGTC_2424 5537928 59.2 µM -0.710333709064911 0.266852898468684 no 2471 0.238748610420964 3761 5382802
SGTC_2378 9074213 121.43 µM -0.710562382529265 0.266778819075208 no 2472 0.238677730420068 3672 657714
SGTC_2842 9000675 19.48 µM -0.71182658416325 0.266369465137484 no 2473 0.238286084283267 3669 2989072
SGTC_1984 st072354 53.1 µM -0.712258693798827 0.266229619094584 no 2474 0.238152298693085 3628 5762938
SGTC_1253 0550-0034 176 µM -0.713779408444 0.265737757498081 no 2475 0.237681797262096 3668 5969915
SGTC_2571 chrysanthemic acid 100 µM -0.713865307073002 0.265709988104488 no 2476 0.237655235885421 3680 2743 An insecticide.
SGTC_2783 7738165 71.43 µM -0.7140505896105 0.265650094792622 no 2477 0.237597948790441 3657 17201110
SGTC_638 3970-0837 4.09 µM -0.71611684054133 0.264982635226068 no 2478 0.236959603005168 3693 4118451 YLR208W SEC13
SGTC_1512 0259-0544 12.2 µM -0.718023738810027 0.264367408217266 no 2479 0.236371324931244 3682 18476
SGTC_125 0133-0007 11.75 µM -0.718070792146878 0.264352236487814 no 2480 0.236356819149456 3782 26541
SGTC_620 0109-0052 432 µM -0.718327895068527 0.264269344861612 no 2481 0.236277567137891 3686 493037
SGTC_2778 tioconazole 65.09 nM -0.719803605825155 0.2637938224133 no 2482 0.23582296224799 3672 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2157 5649910 96.377 µM -0.719827303862567 0.263786189688878 no 2483 0.235815665807994 3681 2858091
SGTC_1013 4112-3890 241 µM -0.719960505790678 0.263743289767264 no 2484 0.235774656294237 3680 705171
SGTC_1290 0986-0249 10.2 µM -0.71999477570491 0.263732253140433 no 2485 0.235764106088105 3660 53329
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.720218774451597 0.263660120139827 no 2486 0.235695153093232 3738 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_560 2332-1943 155 µM -0.721017150694862 0.263403105616034 no 2487 0.235449481342283 3697 21177716
SGTC_1944 st076371 56.9 µM -0.722859956298677 0.262810355494555 no 2488 0.234882963692675 3726 24208455
SGTC_2537 larixol 68.93 µM -0.723698921347656 0.262540723224886 no 2489 0.234625297755918 3718 6708759
SGTC_1049 3226-0134 66 µM -0.723909982056903 0.262472913402071 no 2490 0.234560500656687 3748 5702385
SGTC_1641 st009299 47.1 µM -0.724254664777792 0.2623621926295 no 2491 0.234454701959736 3647 4046054
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.724746027133788 0.262204396025606 no 2492 0.234303926314635 3710 4330530
SGTC_2306 7482397 179.52 µM -0.725385200571706 0.261999204011703 no 2493 0.234107874845003 3713 891448
SGTC_2920 7982904 15.77 µM -0.727996127397394 0.261161881442531 no 2494 0.233307978448349 3706 6456808
SGTC_1401 3807-4679 7.6 µM -0.728827713985426 0.260895481215826 no 2495 0.233053528304565 3713 3291456
SGTC_1337 1486-1011 40.3 µM -0.729907445715107 0.260549795922805 no 2496 0.232723380382862 3740 X1337
SGTC_1272 0839-0021 27 µM -0.730221756616709 0.260449210948823 no 2497 0.232627322886514 3751 5027250
SGTC_2471 5466956 24.79 µM -0.73144197162044 0.260058910456168 no 2498 0.232254618272695 3687 724419
SGTC_1440 4100-1550 40 µM -0.731866855531342 0.259923077030267 no 2499 0.23212491901687 3737 742806
SGTC_27 0485-0001 32.618 µM -0.732283054736861 0.259790055554197 no 2500 0.231997909934511 3661 2054479
SGTC_647 0140-0236 81 µM -0.733463128399424 0.259413083165381 no 2501 0.231638004218501 3732 990837
SGTC_2141 5621638 7.665 µM -0.733708625951597 0.259334694940095 no 2502 0.231563170069186 3744 2856238
SGTC_3154 9100113 49.47 µM -0.733947828042778 0.259258328651204 no 2503 0.231490267907104 3734 25237525
SGTC_906 1165-0455 526 µM -0.734070723572424 0.25921909824843 no 2504 0.231452817735206 3705 3252859
SGTC_993 3909-8757 62.7 µM -0.734434964827478 0.25910284409398 no 2505 0.231341841699736 3706 4288324 YLR208W SEC13
SGTC_2484 5809818 12.04 µM -0.735782584412926 0.258672961528018 no 2506 0.230931510752795 3737 2870548
SGTC_3223 9129970 49.47 µM -0.736986794034931 0.258289138496791 no 2507 0.230565190137049 3784 17248386
SGTC_2145 5634607 200 µM -0.73817767600872 0.257909853932739 no 2508 0.230203243377054 3706 308662
SGTC_1181 1222-0449 220 µM -0.738637204176587 0.257763575893091 no 2509 0.230063663235177 3769 658318
SGTC_605 1315-0399 119 µM -0.739108923517572 0.257613461935859 no 2510 0.229920429336012 3811 24020461
SGTC_1327 1436-0082 2.18 µM -0.739640803400207 0.257444257720062 no 2511 0.229758988046131 3754 15992205
SGTC_1287 0971-0001 34.6 µM -0.740213651155677 0.257262085207433 no 2512 0.229585182817959 3725 4665869
SGTC_2461 5755302 26.15 µM -0.740270465466685 0.257244021222706 no 2513 0.229567949052584 3727 2788904
SGTC_1633 st005664 67.9 µM -0.741563877222397 0.256832962247908 no 2514 0.229175808202799 3770 2063822
SGTC_576 1073-0113 22.7 µM -0.741583711251972 0.25682666146065 no 2515 0.229169797782084 3881 5439563
SGTC_118 0083-0097 135.343 µM -0.741695084982216 0.256791282238292 no 2516 0.229136049198345 3792 5207356
SGTC_1703 st026983 48.3 µM -0.741712295987595 0.256785815179051 no 2517 0.229130834150247 3747 1104023
SGTC_1323 1348-1351 11.2 µM -0.741993521556777 0.256696492732105 no 2518 0.229045630380322 3704 6989654
SGTC_301 4119-0100 24.5 µM -0.743012674905827 0.256372926353986 no 2519 0.228737003347738 3774 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2712 st079126 47.7 µM -0.743647897541353 0.256171359977334 no 2520 0.2285447590309 3741 3152970
SGTC_157 1348-1695 65.819 µM -0.744256163800602 0.255978424772403 no 2521 0.228360757907975 3728 5380510
SGTC_3025 9087895 49.47 µM -0.744610667985528 0.25586601501643 no 2522 0.228253558464178 3766 17173641
SGTC_2280 7785178 200 µM -0.744628848437791 0.255860250870162 no 2523 0.228248061592525 3755 2954328
SGTC_1392 3455-1037 33.9 µM -0.744686897005302 0.255841846917328 no 2524 0.228230511068226 3736 981132
SGTC_2802 7925815 54.55 µM -0.744947688881403 0.255759172930942 no 2525 0.228151672072408 3762 1262923
SGTC_3274 9138298 49.47 µM -0.74608417414294 0.255399057085346 no 2526 0.227808284377145 3722 17015756
SGTC_1243 0416-0003 5.65 µM -0.746126099396599 0.255385777382669 no 2527 0.227795622275785 3761 2141977
SGTC_3055 9094636 49.47 µM -0.746209513003051 0.255359357437647 no 2528 0.22777043120212 3758 25236176
SGTC_236 1509-0011 5.31 µM -0.747601956743823 0.254918533881958 no 2529 0.227350142058304 3812 3107280
SGTC_717 1532-0246 73.2 µM -0.748906673202327 0.254505844946614 no 2530 0.226956728960754 3756 9561992
SGTC_2515 chrysin 20.77 µM -0.749224063485806 0.254405505627916 no 2531 0.226861083886525 3772 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1354 1498-1681 81 µM -0.74948632012127 0.254322611828962 no 2532 0.226782070411109 3811 5754243
SGTC_1240 0356-0016 42.1 µM -0.749780977263083 0.254229493805672 no 2533 0.22669331373841 3752 4305613
SGTC_158 k038-0087 26.446 µM -0.750927202373687 0.253867432009189 no 2534 0.226348234135877 3701 X158
SGTC_1238 0333-0287 48.8 µM -0.751486843729277 0.253690754683557 no 2535 0.226179857793459 3760 7226
SGTC_3057 9095946 49.47 µM -0.751769847616297 0.253601435678601 no 2536 0.22609473885853 3770 24540043
SGTC_2893 9048488 25.97 µM -0.753487658517033 0.253059631122829 no 2537 0.225578462386457 3754 6467338
SGTC_2300 7976697 71.57 µM -0.753513509025544 0.253051482420671 no 2538 0.225570698289337 3694 2236109
SGTC_764 1951-2361 146 µM -0.755631087759987 0.252384439758462 no 2539 0.224935205770699 3741 5438930
SGTC_2768 sulfasalazine 50.2 µM -0.756593682383741 0.252081526706871 no 2540 0.224646663713968 3768 5384001 An antioxidant and salicylic acid derivative.
SGTC_1471 k673-0312 37 µM -0.75737758592973 0.251834986630731 no 2541 0.224411840296793 3755 24099884
SGTC_259 usnic acid 108.925 µM -0.75936818725116 0.251209508863234 no 2542 0.223816169164847 3834 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2434 5670830 169.91 µM -0.760921113719473 0.250722126368789 no 2543 0.223352093340501 3800 1549830
SGTC_1804 st050076 49.1 µM -0.762928124148196 0.250092973199133 no 2544 0.222753131207625 3803 3895976
SGTC_1328 1441-0025 69.2 µM -0.763245568833782 0.249993538112067 no 2545 0.222658478519122 3733 4562601
SGTC_174 3553-0389 74.3 µM -0.764029217611792 0.249748160988993 no 2546 0.222424915634337 3759 738071
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.764395242114253 0.249633594754444 no 2547 0.222315871622821 3812 6708784 An antioxidant flavonoid
SGTC_2405 ticlatone 3.52 µM -0.76526584078337 0.249361208229382 no 2548 0.222056630222407 3684 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_833 3852-0053 558 µM -0.766405204239995 0.249004971369332 no 2549 0.221717618585239 3841 3123681
SGTC_2408 sulbentine 18.36 µM -0.76760854368511 0.248629025815161 no 2550 0.22135989252047 3785 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_527 4476-4215 268 µM -0.768764890591622 0.248268046655484 no 2551 0.221016447471796 3787 4418754
SGTC_3003 9075612 71.4286 µM -0.768967405252861 0.248204856010643 no 2552 0.220956330260721 3805 6501993
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.770649044689688 0.247680465585262 no 2553 0.220457491200567 3787 676296 Flavone; oxidizing agent.
SGTC_2115 tiliquinol 12.7705 µM -0.7710649743396 0.247550856385107 no 2554 0.220334210073354 3789 71208 A bioactive hydroxyquinoline.
SGTC_1442 4112-3290 3 µM -0.771072285354435 0.247548578499933 no 2555 0.220332043449468 3792 704353
SGTC_1857 st056007 79.3 µM -0.771092495031589 0.24754228185042 no 2556 0.220326054362363 3783 619834
SGTC_2957 9076800 11.52 µM -0.77235448794616 0.247149257246772 no 2557 0.219952250848657 3766 16459615
SGTC_2470 5664817 21.68 µM -0.772489397504521 0.247107261887932 no 2558 0.219912312049812 3813 2859561
SGTC_1591 genipin 88.4 µM -0.773593549271156 0.246763699206486 no 2559 0.219585593997464 3815 442424 A DNA cross-linking agent.
SGTC_1461 k072-0203 53.8 µM -0.773834455884549 0.246688773836659 no 2560 0.219514346895151 3726 5418714
SGTC_1970 st070122 35.8 µM -0.774986816031392 0.246330542084321 no 2561 0.219173725034829 3788 102928
SGTC_2900 5328528 85.29 µM -0.77510925888974 0.246292494928447 no 2562 0.219137550471729 3808 795359
SGTC_3290 9121031 71.43 µM -0.776031657780939 0.24600597554464 no 2563 0.218865146963918 3789 17014854
SGTC_2223 6903751 107.57 µM -0.777552961835083 0.245533812710051 no 2564 0.218416300239413 3749 5598863
SGTC_1838 st055369 84.5 µM -0.778084250773627 0.245369032836381 no 2565 0.218259673333211 3785 676036
SGTC_2457 5731572 11.68 µM -0.778165112180313 0.245343958790656 no 2566 0.218235840620577 3855 2865357
SGTC_1381 2324-0066 62.1 µM -0.780444399325209 0.24463774905953 no 2567 0.217564671298559 3837 10885928
SGTC_2232 chlorophetanol 41.5365 µM -0.780968755721093 0.24447543855794 no 2568 0.21741043564046 3868 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_172 1112-0046 2.638 µM -0.782110986316323 0.244122070774176 no 2569 0.217074675360531 3773 2802135 YIL048W NEO1
SGTC_94 0334-0113 514.748 µM -0.78293619329564 0.243866950929219 no 2570 0.216832291150877 3811 6795178
SGTC_344 k064-0035 6.43 µM -0.782957247063956 0.243860443858173 no 2571 0.216826109173124 3797 5088750
SGTC_598 3937-0236 20.2 µM -0.784598862429953 0.243353359736909 no 2572 0.216344398621076 3876 1379313
SGTC_970 1315-0089 19.5 µM -0.786691023405402 0.24270793179583 no 2573 0.215731380081702 3765 6811083 YLR033W RSC58
SGTC_1845 st056753 3.01 µM -0.786751319698965 0.242689344244796 no 2574 0.215713727765557 3780 5375839
SGTC_755 1995-0008 37.3 µM -0.787232346769421 0.242541085530317 no 2575 0.215572932483029 3795 689533
SGTC_2627 acetyl isogambogic acid 100 µM -0.787765727448642 0.242376748129186 no 2576 0.215416875770236 3806 6857789 A caspase activator and apoptosis inducer.
SGTC_1815 st051655 58.2 µM -0.788841083170587 0.242045608872409 no 2577 0.215102447143269 3745 5984156
SGTC_463 ikarugamyin 104 µM -0.791334358832864 0.24127878775826 no 2578 0.214374451751669 3856 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2822 7994718 71.43 µM -0.791480146983467 0.241233990673121 no 2579 0.21433192840361 3775 1018011
SGTC_373 0844-0104 25.9 µM -0.791868178384244 0.241114780271701 no 2580 0.21421877168585 3875 5375804
SGTC_1783 st039459 87.517 µM -0.792063776019622 0.241054701214574 no 2581 0.21416174518539 3935 729761
SGTC_98 0074-0023 107.663 µM -0.792867095854855 0.240808041807605 no 2582 0.213927629901959 3769 3563821
SGTC_198 3454-2873 16.191 µM -0.795381703471886 0.240036819905067 no 2583 0.213195749846637 3813 710957
SGTC_2208 7283366 200 µM -0.795415862538819 0.240026352710578 no 2584 0.213185817866093 3802 898663
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.79588107290056 0.239883825369965 no 2585 0.213050581661187 3836 5106787 A p450 inhibitor.
SGTC_318 1488-0629 67.2 µM -0.79642754073887 0.239716462007713 no 2586 0.212891787929078 3882 3662576
SGTC_3286 9117135 37.221 µM -0.797186609645462 0.23948409238026 no 2587 0.212671330797849 3807 3438150
SGTC_3049 9092223 49.47 µM -0.797742600404128 0.23931396802623 no 2588 0.21250993846721 3805 8623917
SGTC_121 0557-0495 61.343 µM -0.797762134530722 0.239307992094037 no 2589 0.21250426942566 3962 3104427
SGTC_78 0336-0123 156.75 µM -0.798906464269656 0.238958057985921 no 2590 0.212172325191985 3685 6765896
SGTC_744 1594-0068 283 µM -0.799200107787229 0.238868307423665 no 2591 0.212087194732706 3842 668392
SGTC_3143 9086658 49.47 µM -0.800467640089284 0.238481104625261 no 2592 0.211719952542315 3920 25236626
SGTC_2971 9092186 9.93 µM -0.801378177982702 0.238203167864703 no 2593 0.211456372202128 3862 25236400
SGTC_2961 9083290 32.55 µM -0.801763077597981 0.238085732729111 no 2594 0.211345010187264 3788 17741490
SGTC_2838 9002687 71.43 µM -0.802028927176428 0.238004638989827 no 2595 0.211268112675386 3834 6457060
SGTC_2206 7254556 146.969 µM -0.804121847351597 0.237366751718204 no 2596 0.2106633041349 3844 4398905
SGTC_857 0438-0306 1.35 µM -0.804851915078931 0.23714446025477 no 2597 0.21045256960379 3911 4686136
SGTC_1122 capsaicin 818.572 nM -0.805108012119477 0.23706651077831 no 2598 0.210378676350237 3941 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2865 9030313 51.95 µM -0.805368900903592 0.236987117295665 no 2599 0.21030341616986 3786 42562754
SGTC_1613 st002381 52.1 µM -0.806237536319736 0.236722880169289 no 2600 0.21005294958063 3809 551167
SGTC_2872 9044037 25.97 µM -0.806391746649832 0.23667598664423 no 2601 0.210008502145126 3828 6465195
SGTC_2731 amoxapine 43.43 µM -0.807491840670571 0.236341609445313 no 2602 0.209691586749159 3897 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1470 k295-0292 231 µM -0.808990135550599 0.235886616437607 no 2603 0.209260410179417 3899 5045612
SGTC_3009 9080819 71.4286 µM -0.809346634386846 0.235778428208148 no 2604 0.209157894505535 3869 17027216
SGTC_3077 9117319 49.47 µM -0.809468313822465 0.235741507892141 no 2605 0.209122910840239 3810 17154678
SGTC_1483 3453-0561 55.9 µM -0.810581286914906 0.235403954452727 no 2606 0.208803083420908 3861 4546991
SGTC_419 nsc-638432 893 µM -0.812345818907131 0.234869336966071 no 2607 0.208296613139459 3815 368090
SGTC_981 1488-1094 54.9 µM -0.812364817238336 0.234863584509864 no 2608 0.208291164030894 3823 3449522
SGTC_3059 1327-0034 3 µM -0.812553408910891 0.234806485542056 no 2609 0.208237076656876 3785 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_684 1140-0066 328 µM -0.812876804723269 0.234708590455159 no 2610 0.208144347259953 3889 6813534
SGTC_1772 st048439 82.2 µM -0.814308323892202 0.234275526700185 no 2611 0.207734171183271 3903 2927068 YDL195W SEC31
SGTC_3092 9117248 49.47 µM -0.814416202197746 0.234242909243216 no 2612 0.207703279953724 3924 17141857
SGTC_1767 st044992 70.3 µM -0.815406259529785 0.233943678703809 no 2613 0.207419901258559 3904 9600693
SGTC_1017 4239-0030 168 µM -0.815854434350603 0.233808293993137 no 2614 0.207291697813853 3899 1149593
SGTC_3026 9090633 49.47 µM -0.817889768980605 0.233194006513477 no 2615 0.206710066412647 3869 25236842
SGTC_2817 7995342 71.43 µM -0.819316390809026 0.232763970176009 no 2616 0.206302961668748 3860 18879975
SGTC_522 1273-0010 11.6 µM -0.821202246673667 0.232196180726748 no 2617 0.205765538515136 3989 5705015
SGTC_830 4076-0286 57.8 µM -0.821896131360914 0.231987461548284 no 2618 0.205568007479337 3919 6866659
SGTC_2663 amphotericin b 100 µM -0.822225750556829 0.23188834933979 no 2619 0.205474212867958 3843 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_640 3381-0960 37.1 µM -0.823801513493457 0.231414863905064 no 2620 0.20502617374692 3902 1745025
SGTC_1439 4092-1168 46 µM -0.825041301000288 0.231042711670076 no 2621 0.204674071574382 3870 2886240
SGTC_1018 4259-0013 28.1 µM -0.825555296233758 0.230888521565242 no 2622 0.204528201428462 3962 6801262
SGTC_2889 9059656 51.95 µM -0.829255453491978 0.229780232561112 no 2623 0.203479936046754 3963 3949838
SGTC_619 1652-1634 108 µM -0.830342823421767 0.229455105498773 no 2624 0.203172491327169 3841 5400454
SGTC_1368 1852-0141 284 µM -0.830487617348928 0.229411831114077 no 2625 0.203131572990701 3874 2838987
SGTC_70 0141-0289 43.283 µM -0.830872706340153 0.229296762299597 no 2626 0.20302277192245 3900 352408
SGTC_3337 9144342 33.5465 µM -0.832542156314495 0.228798286729876 no 2627 0.202551496681128 3893 17682949
SGTC_1132 3456-3614 2.5 µM -0.832983141758671 0.228666715975774 no 2628 0.2024271185316 3975 3125502
SGTC_1563 conessine 56.1 µM -0.833539154176835 0.228500886778582 no 2629 0.202270362599783 3955 441082 An anti-amoebic, histamine inhibitor.
SGTC_150 3970-0969 77.2 µM -0.834962441790185 0.22807670306722 no 2630 0.201869427752126 3980 6615640
SGTC_787 4152-0075 138 µM -0.835570378475758 0.227895654201279 no 2631 0.201698319362157 3911 9566539
SGTC_696 1560-0013 611 µM -0.835960332552728 0.227779565045254 no 2632 0.201588609574978 3917 1650269
SGTC_1752 st044819 83.042 µM -0.837545132665661 0.227308113385181 no 2633 0.201143109491498 3899 441209 YML126C ERG13
SGTC_1356 1502-0781 85.8 µM -0.838358013570923 0.227066508341378 no 2634 0.200914831385231 3843 567702
SGTC_582 0987-0078 156 µM -0.840183890377363 0.226524348134613 no 2635 0.200402644712974 3923 1625765
SGTC_343 4130-2827 29.8 µM -0.840774221500843 0.226349216740753 no 2636 0.200237215639068 3941 1118244
SGTC_2881 9058953 51.95 µM -0.841738906370094 0.226063191843265 no 2637 0.199967057729059 3856 17122249
SGTC_1686 st019653 115.5 µM -0.842158880597755 0.225938735155613 no 2638 0.199849513363479 3837 97252
SGTC_256 clotrimazole 625 nM -0.842656089526107 0.225791440551223 no 2639 0.199710405921963 3829 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1204 4049-0315 18.3 µM -0.843086779323786 0.225663895676752 no 2640 0.199589956077099 4007 588402
SGTC_3292 9120825 59.784 µM -0.843217687446281 0.225625136504025 no 2641 0.199553354023636 3857 24824900
SGTC_614 0462-0418 107 µM -0.843585316170415 0.225516309429513 no 2642 0.199450586236869 3710 5188303
SGTC_3138 9097216 49.47 µM -0.843706512812213 0.225480438778473 no 2643 0.199416713630452 3884 25237486
SGTC_2244 6635614 200 µM -0.844020358368973 0.225387564711293 no 2644 0.199329014698217 3817 836499
SGTC_1207 2099-0101 141 µM -0.844053592283569 0.225377731305384 no 2645 0.19931972939234 3925 5837381
SGTC_32 0928-0142 34.1 µM -0.844342746066181 0.225292185384832 no 2646 0.199238952991203 3846 2244242
SGTC_2440 5628896 157.78 µM -0.845123247477618 0.225061366482778 no 2647 0.199021014888496 3909 5522048
SGTC_2217 6934799 96.0675 µM -0.845724783255269 0.224883564838811 no 2648 0.198853147117183 3821 675606
SGTC_263 alizarin 107.927 µM -0.845827735864107 0.224853142140694 no 2649 0.198824425171169 3900 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_159 3970-0959 50 µM -0.846809921987015 0.224563021550872 no 2650 0.198550538475827 3975 6615653
SGTC_2464 5717415 7.67 µM -0.847164801607869 0.224458248575276 no 2651 0.198451634809838 3887 5285744
SGTC_1569 carminic acid 40.6 µM -0.847241718126136 0.224435543765732 no 2652 0.198430202374591 3966 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2552 juarezic acid 87.02 µM -0.847328028181693 0.224410067651569 no 2653 0.198406154136142 3909 1549512
SGTC_2680 butyl paraben 22.24 µM -0.848127743003419 0.224174094130055 no 2654 0.198183416320186 3955 7184 An antifungal and steroid mimetic.
SGTC_843 0310-0051 143 µM -0.848941623329392 0.223934085508131 no 2655 0.197956888165532 3928 2065037
SGTC_888 0916-0002 6.97 µM -0.8496020933351 0.223739424076189 no 2656 0.197773173866454 3980 2802138 YIL048W NEO1
SGTC_1295 1013-0063 9.78 µM -0.849897084777135 0.223652511841923 no 2657 0.19769115325051 3878 6826038
SGTC_663 1486-0733 13.9 µM -0.849984149781931 0.223626863872176 no 2658 0.197666949273439 3918 722445 YPR165W RHO1
SGTC_1391 3442-0225 151 µM -0.850425041891085 0.223497009731593 no 2659 0.197544409245875 3855 5227075
SGTC_584 0986-0246 15.4 µM -0.853065292067068 0.222720285800007 no 2660 0.196811548703658 4000 53315 YDR232W HEM1
SGTC_3276 9139060 49.47 µM -0.854661312360824 0.222251506463813 no 2661 0.196369337032299 3977 4870619
SGTC_878 0828-0289 13.7 µM -0.855027800216077 0.222143942047063 no 2662 0.196267878796763 3873 745350 YLR208W SEC13
SGTC_1387 3342-1166 1.8 µM -0.855377569404528 0.222041312285145 no 2663 0.196171078590534 3903 3418228
SGTC_1182 1222-0449 220 µM -0.855549025104185 0.221991013403445 no 2664 0.196123638025638 3907 658318
SGTC_3000 9075062 71.4286 µM -0.856818755972054 0.221618722974486 no 2665 0.195772529184684 3879 17057871
SGTC_3116 9124943 49.47 µM -0.857661236053816 0.22137190131159 no 2666 0.195539775377437 3895 41905195 YPL160W CDC60
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.861123329809778 0.220359262353175 no 2667 0.194585060627157 3856 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1797 st048695 56.8 µM -0.861207665098711 0.220334628028037 no 2668 0.194561839585202 3894 592262 YIL048W NEO1
SGTC_2611 pyromycin 23.93 µM -0.861862652179728 0.220143360153035 no 2669 0.194381551587554 3921 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1431 4049-0260 9.09 µM -0.862159434681175 0.220056725745197 no 2670 0.194299894428242 3892 3854841
SGTC_309 k408-0051 1.48 µM -0.862307461854118 0.22001352213148 no 2671 0.194259173829957 3876 3640463
SGTC_2033 5192550 145 µM -0.862395086331983 0.219987950105917 no 2672 0.194235071777686 3905 182073
SGTC_149 3970-0822 46.1 µM -0.862519947029038 0.219951514137037 no 2673 0.194200730650648 3930 3114250 YBL034C STU1
SGTC_3165 9101544 49.47 µM -0.864669456677575 0.219324802542738 no 2674 0.193610119093276 3934 5002184
SGTC_1158 4092-0494 91.8 µM -0.865415757673819 0.219107451066666 no 2675 0.193405317616515 4019 1148199
SGTC_1603 st002045 67.8 µM -0.867234552899657 0.218578267161 no 2676 0.19290675390279 3927 5887985
SGTC_2259 7964009 200 µM -0.867821155352859 0.218407750484004 no 2677 0.192746123432233 3972 313134
SGTC_1637 st007924 17.4 µM -0.868573725548051 0.218189101673331 no 2678 0.192540165417076 3881 683336
SGTC_2478 5763493 32.33 µM -0.868738332751578 0.218141294156134 no 2679 0.192495134834617 3870 1365576 YLR208W SEC13
SGTC_1994 st072947 40.9 µM -0.87010761351529 0.217743842619276 no 2680 0.192120798686464 3993 5286565 YDL195W SEC31
SGTC_1148 3909-7663 27.7 µM -0.870388154210291 0.217662463630825 no 2681 0.192044159036148 3981 4084526
SGTC_2012 4023501 200 µM -0.870744012602758 0.217559261806844 no 2682 0.191946970604299 3957 3477460
SGTC_2028 5153890 36.43 µM -0.871641765430416 0.217299031723711 no 2683 0.191701919269943 3906 2830968 YPR165W RHO1
SGTC_654 1124-0271 80.9 µM -0.871805074706714 0.217251712873816 no 2684 0.191657362842889 3926 5403748
SGTC_3079 9117512 49.47 µM -0.871837865718047 0.217242212398394 no 2685 0.191648417083918 3947 7185044
SGTC_3175 9106517 49.47 µM -0.872352115165656 0.217093251308012 no 2686 0.191508157471142 3967 41468073
SGTC_421 streptovitacin 30 mM -0.875463239031806 0.216193320863036 no 2687 0.19066095190094 4019 91467 include heat shock
SGTC_2549 cedrol 20.94 µM -0.875694365863227 0.216126550925664 no 2688 0.190598104539001 3854 6708665 A sedative which affects the nervous system.
SGTC_1233 0325-0408 14.2 µM -0.876667099681894 0.215845670019681 no 2689 0.190333740894537 3989 12874
SGTC_765 1319-0117 244 µM -0.877964785469366 0.215471287448638 no 2690 0.189981414637579 3902 3487746 YGL099W LSG1
SGTC_1688 st021091 57.6 µM -0.878847468868894 0.21521684851869 no 2691 0.189741992231202 3952 3656366
SGTC_3207 9114163 49.47 µM -0.87906094551102 0.215155338758558 no 2692 0.189684115892717 3959 849233
SGTC_1319 1306-0155 43.7 µM -0.879769492438169 0.214951255851816 no 2693 0.189492097302801 3971 3122360
SGTC_3295 9122362 53.5725 µM -0.881097239316132 0.214569127544772 no 2694 0.189132595675999 4011 4730473
SGTC_1455 4262-0120 131 µM -0.8811245441318 0.214561273308351 no 2695 0.189125207016314 4040 1529587
SGTC_3193 9111931 49.47 µM -0.883018999609032 0.214016740946539 no 2696 0.188613003080763 3958 17087244
SGTC_392 N-ethylmaleimide 8.33 µM -0.883132585823299 0.213984117900458 no 2697 0.188582319975545 3889 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3167 9103034 49.47 µM -0.885883358835868 0.213194953931529 no 2698 0.187840192173523 3990 5127859
SGTC_2343 7990716 14.84 µM -0.886000307162846 0.213161440509455 no 2699 0.187808680842743 3947 6456862
SGTC_2370 9071495 200 µM -0.887981747651236 0.212594094114447 no 2700 0.187275284759285 3967 21791103
SGTC_3053 9095903 49.47 µM -0.889361189389973 0.21219963941772 no 2701 0.186904498001759 4052 17174018
SGTC_2852 9023854 51.95 µM -0.890234799006652 0.211950050068888 no 2702 0.186669911396627 4046 19798528
SGTC_2922 7999257 32.47 µM -0.891922936649555 0.211468237716587 no 2703 0.186217119839032 3923 2988377
SGTC_2344 7990960 76.95 µM -0.894349499827742 0.210776795640922 no 2704 0.185567461579376 3943 140813
SGTC_3212 9128307 49.47 µM -0.894652759165627 0.210690476095111 no 2705 0.185486369631426 3925 27243542
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.89528146667094 0.210511587268064 no 2706 0.185318322492303 3955 4620898
SGTC_378 3970-0959 8.33 µM -0.895752003072215 0.210377761882685 no 2707 0.185192614753796 3996 6615653
SGTC_2256 7954252 200 µM -0.896170763324066 0.21025870418142 no 2708 0.185080783996806 3986 2972920
SGTC_200 k038-0079 37.545 µM -0.896939109389052 0.210040358690316 no 2709 0.184875704781193 3921 3436683
SGTC_2319 6033012 152.6 µM -0.898346480049039 0.209640763440556 no 2710 0.184500429957903 3921 847246
SGTC_1891 st059073 26.2 µM -0.900779098535557 0.20895112444499 no 2711 0.183852891402738 4057 688754
SGTC_3282 9108498 15.4605 µM -0.900900772737523 0.208916665354309 no 2712 0.18382054016863 3967 16459645
SGTC_1173 0443-0020 122 µM -0.901272446354877 0.208811425197324 no 2713 0.183721740028486 3966 5331295
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.902221672063509 0.208542791770262 no 2714 0.183469562280227 4015 5379071
SGTC_626 0214-0009 33 µM -0.903233429421906 0.208256686179551 no 2715 0.183201009625923 4042 3437874
SGTC_1834 st055981 52.8 µM -0.905824992322877 0.207524898986794 no 2716 0.182514245235858 4019 471719 YDL150W RPC53
SGTC_407 eburnamonine 100 µM -0.907084871533976 0.207169692882441 no 2717 0.182180958791219 3837 3195
SGTC_2833 9001315 45.46 µM -0.907583096407895 0.207029324321765 no 2718 0.182049264203169 3963 2989378
SGTC_668 1682-0499 62.6 µM -0.907948797321744 0.206926328532342 no 2719 0.181952637243998 3979 682214
SGTC_1284 0929-0043 16 µM -0.908087069934765 0.206887393417183 no 2720 0.18191611065811 3944 1239883
SGTC_2936 9038235 15.59 µM -0.911572863844762 0.205907288916062 no 2721 0.180996806347125 3928 4749415
SGTC_441 propafenone 146 µM -0.913292650794617 0.205424750940412 no 2722 0.180544323265569 3976 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_347 4534-1311 26.2 µM -0.914139731438035 0.205187324034393 no 2723 0.180321713852767 3995 2862016
SGTC_3341 9147222 25.867 µM -0.914305882345722 0.205140772992053 no 2724 0.180278070270074 4000 1939759
SGTC_2544 sphondin 68.51 µM -0.914617902713004 0.205053370188314 no 2725 0.180196128435991 3980 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1769 st044406 64.4 µM -0.916965241793241 0.204396546047745 no 2726 0.179580427109003 3972 670903
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.917563898478772 0.204229232697386 no 2727 0.179423612761385 3912 5355888
SGTC_46 0329-0187a 2.197 µM -0.918672137118688 0.203919716043865 no 2728 0.179133543903855 4052 46494817
SGTC_2812 7970281 58.44 µM -0.919067824914138 0.203809273339651 no 2729 0.179030048629863 4047 2233435
SGTC_2786 7743617 45.45 µM -0.919175986771417 0.203779089865723 no 2730 0.179001764589195 3943 583674
SGTC_2482 5981709 142.65 µM -0.920213974675649 0.20348956614148 no 2731 0.178730476465872 3958 877755
SGTC_1929 genistein trimethyl ether 50.5 µM -0.920294370076858 0.203467151868891 no 2732 0.178709475161022 3966 136420
SGTC_226 1,3-diallylurea 8.28947 mM -0.921608300047524 0.20310103639804 no 2733 0.178366463762675 3959 74537 YKL182W FAS1
SGTC_972 1319-0219 195 µM -0.922412923439703 0.202877029202932 no 2734 0.178156615646902 3970 23903702
SGTC_1406 3909-7906 11.9 µM -0.923658098944285 0.202530663331464 no 2735 0.177832177162984 3991 X1406
SGTC_1412 3909-8563 178 µM -0.923970984158614 0.202443684813698 no 2736 0.177750711533392 4073 23767530
SGTC_3280 9140961 49.47 µM -0.924215524001313 0.202375721081137 no 2737 0.177687057318236 4042 4901226
SGTC_2499 avocadenofuran 51.48 µM -0.924870825173799 0.202193663797187 no 2738 0.177516552022098 3977 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1996 st072960 66.8 µM -0.92570039746343 0.20196333069806 no 2739 0.177300850634648 4035 1719405
SGTC_521 r062-0005 13.8 µM -0.928824153009369 0.201097421326323 no 2740 0.176490112586124 3906 2832033
SGTC_520 3584-0023 682 µM -0.92895159622903 0.201062141227616 no 2741 0.176457085895072 4016 1340790
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.92916641302822 0.20100268190966 no 2742 0.176401425340613 4048 279621
SGTC_2487 5918373 44.05 µM -0.93002665601349 0.200764680266022 no 2743 0.176178641607447 4068 2876279
SGTC_1848 st056003 16.4 µM -0.931330607431152 0.200404241409153 no 2744 0.175841287013428 4045 146492
SGTC_1168 k815-0004 80.5 µM -0.931495923660382 0.200358572401152 no 2745 0.175798546113246 3992 642433
SGTC_1385 3091-4834 14.1 µM -0.932238738360078 0.20015344521824 no 2746 0.175606579835219 3995 4072814
SGTC_2706 st078239 82.5 µM -0.933019401513888 0.199938002330019 no 2747 0.175404975562885 3980 15434492
SGTC_2652 actinonin 100 µM -0.9341013258601 0.199639649782885 no 2748 0.175125814047964 4004 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2303 7774051 200 µM -0.935937564974961 0.199133900219482 no 2749 0.17465266731076 4038 2953184
SGTC_1198 1612-1005 86.7 µM -0.935985799600933 0.199120625520047 no 2750 0.174640249566037 4099 6998509
SGTC_1372 2752-0194 270 µM -0.936624694073633 0.198944845036332 no 2751 0.174475822516602 3963 823334
SGTC_3239 9133757 49.47 µM -0.93756408357806 0.198686558580783 no 2752 0.174234238159607 4020 17036923
SGTC_3206 9114350 49.47 µM -0.937946278876788 0.198581531346745 no 2753 0.174136009226419 3934 17087243
SGTC_2367 9070478 135.38 µM -0.938707163088148 0.198372540150245 no 2754 0.173940557360443 3965 572802
SGTC_1917 st066507 28.5 µM -0.940227183821934 0.197955435402964 no 2755 0.173550520431246 3991 3156428
SGTC_2703 st077852 53.4 µM -0.942527398070171 0.19732524814429 no 2756 0.172961345351435 4073 6281836
SGTC_349 k015-0014 24 µM -0.943643274671903 0.197019970229446 no 2757 0.172675985206166 4003 2196908
SGTC_960 1222-0186 7.7 µM -0.94373359154541 0.196995274142098 no 2758 0.172652901850108 4069 3126296
SGTC_2996 9066192 71.4286 µM -0.944025742597317 0.196915401705819 no 2759 0.172578246811135 4081 6472854
SGTC_2194 5927483 104.545 µM -0.946587890293871 0.196215765356506 no 2760 0.171924408507456 4035 760979
SGTC_2109 5483026 200 µM -0.946703047275728 0.196184355293526 no 2761 0.171895058614412 4041 759335
SGTC_1711 st032263 62.8 µM -0.948673847974184 0.195647275072006 no 2762 0.171393259465181 4025 3958979
SGTC_3171 9103192 49.47 µM -0.948728161887681 0.195632486160575 no 2763 0.17137944349619 4053 13018434
SGTC_566 0958-0068 16.5 µM -0.950656291626574 0.195107923473656 no 2764 0.170889441456522 3924 6815365
SGTC_3159 9100096 49.47 µM -0.95200442794186 0.194741660879095 no 2765 0.170547368121714 3980 25236875
SGTC_1330 1469-0054 61.8 µM -0.952202345035422 0.194687925859164 no 2766 0.170497185977977 4028 7102664
SGTC_2954 9074818 52.69 µM -0.95258624862112 0.194583720732015 no 2767 0.170399873671583 4056 16648742
SGTC_306 1672-3436 11.6 µM -0.953755235955995 0.194266624958627 no 2768 0.170103776596515 4083 6797378
SGTC_1955 wogonin 32.4 µM -0.954640141831025 0.19402679760543 no 2769 0.16987985496472 4127 5281703 A flavanone.
SGTC_2363 9053361 176 µM -0.954641377264811 0.194026462904089 no 2770 0.169879542475676 4107 6469797 YMR079W SEC14
SGTC_1366 1683-0113 21.9 µM -0.956774005435975 0.193449219926728 no 2771 0.169340667689647 4046 708623
SGTC_2048 5246248 200 µM -0.958976022247855 0.19285429603081 no 2772 0.168785412321263 4052 677046
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.961006808518872 0.192306625692434 no 2773 0.168274372243504 4041 6857784
SGTC_1427 4048-4900 550 nM -0.961389603307012 0.192203498753346 no 2774 0.168178154910789 4029 24132586
SGTC_2580 diallyl disulphide 81.36 µM -0.961396783379602 0.192201564727128 no 2775 0.168176350502855 4038 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2356 9061756 188.97 µM -0.962814682918645 0.191819872273058 no 2776 0.167820265456231 4080 20104043
SGTC_131 0141-0277 33.849 µM -0.963564040508692 0.19161833601154 no 2777 0.167632271298823 4021 1547771
SGTC_2934 9036370 36.88 µM -0.966506877734412 0.190828129078377 no 2778 0.16689530352796 4052 6462800
SGTC_2870 9038528 12.99 µM -0.966896993130698 0.190723526085759 no 2779 0.166797764973162 4113 6463316
SGTC_2023 5144124 124 µM -0.966933617418352 0.190713707695814 no 2780 0.166788609878843 4034 2830192
SGTC_277 nystatin 15.5 µM -0.968817867382088 0.190208988795855 no 2781 0.166318035112556 4040 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2930 9013230 14.89 µM -0.968897615143656 0.190187645520847 no 2782 0.16629813774422 4076 2995857
SGTC_2502 avocadyne acetate 18.59 µM -0.969198026647864 0.190107258165485 no 2783 0.166223197740543 3984 3952079
SGTC_1550 gossypolone 36.6 µM -0.969612727189516 0.189996322427654 no 2784 0.166119783285736 4072 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_129 0088-0017 176.636 µM -0.969637009032404 0.18998982807234 no 2785 0.166113729376978 3894 182446
SGTC_810 3825-7150 143 µM -0.969862398857283 0.189929552437803 no 2786 0.166057542361966 4123 22330411 YGL099W LSG1
SGTC_3135 9127742 49.47 µM -0.96997936051141 0.189898278206444 no 2787 0.166028390046311 4131 3643468
SGTC_1953 st076800 12.1 µM -0.97065508925716 0.189717657927465 no 2788 0.165860031579195 4071 297591
SGTC_1329 1447-1697 50.6 µM -0.972014161258776 0.189354702139956 no 2789 0.165521751773879 4058 2840515
SGTC_3134 9127454 49.47 µM -0.972420006961497 0.189246399312459 no 2790 0.165420821342437 4094 24262820
SGTC_1265 0819-1001 68.8 µM -0.973040969276802 0.189080764913638 no 2791 0.165266470291321 4017 3106768
SGTC_2200 6600604 21.907 µM -0.975471861783616 0.188433212242143 no 2792 0.164663126343604 4036 2904777
SGTC_1546 5-methoxyflavanone 78.7 µM -0.976869373129802 0.188061556503254 no 2793 0.164316912977623 4049 147795
SGTC_2800 7887935 81.82 µM -0.977437267029503 0.18791065954026 no 2794 0.164176360381875 4086 2961002
SGTC_1817 st052116 64.4 µM -0.978911166159554 0.187519373871462 no 2795 0.163811937228583 4079 4361398
SGTC_1604 st002052 72.4 µM -0.981247660510997 0.186900122034963 no 2796 0.16323531313254 4136 6254834 YHR062C RPP1
SGTC_1847 st056231 15 µM -0.981432094465676 0.186851294601511 no 2797 0.163189852855191 4067 5393180
SGTC_831 k061-1017 217 µM -0.981767777864592 0.186762445333605 no 2798 0.163107132913993 4094 1240153
SGTC_134 0269-0018 6.916 µM -0.982145025811833 0.18666262590271 no 2799 0.163014203061406 4039 4378915
SGTC_1864 st057645 30.4 µM -0.985247655622285 0.185842926570416 no 2800 0.162251218676828 4110 688666
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.985925527362827 0.185664133837868 no 2801 0.162084829564024 4111 6708760
SGTC_2122 5258151 111.688 µM -0.986186334482089 0.185595372836267 no 2802 0.162020841955697 4065 2173356
SGTC_2132 5317594 122.667 µM -0.986795525887479 0.185434822953445 no 2803 0.16187144426706 4032 794577
SGTC_2068 5226020 147 µM -0.989370273050372 0.184757211595934 no 2804 0.161241006673482 4109 1810509
SGTC_1206 3978-0017 132 µM -0.989442461743947 0.184738235482564 no 2805 0.161223354085124 4178 3873677
SGTC_143 4032-1194 15.74 µM -0.990235059226545 0.184529966482622 no 2806 0.161029619988096 4092 1806963
SGTC_2735 sertaconazole 140 nM -0.990605670122051 0.184432632043017 no 2807 0.160939083954716 4201 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2071 5230951 39.92 µM -0.993051976709665 0.183790954044023 no 2808 0.160342312685645 4103 1799272
SGTC_254 nsc-64875 3.808 µM -0.993848108717545 0.18358242508243 no 2809 0.160148410277071 4087 56993
SGTC_2081 5214970 32.255 µM -0.994282489467317 0.183468710962664 no 2810 0.160042679078546 4034 2063512
SGTC_1264 0783-0040 158 µM -0.995232694738188 0.183220115122611 no 2811 0.159811551887696 3975 2855798
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.999607668194933 0.182078232475471 no 2812 0.158750205365161 4069 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2411 st077133 39.94 µM -1.00018286792117 0.181928435052826 no 2813 0.158611009293913 4171 1403142 YNL221C POP1
SGTC_1118 chelidonine 707.474 nM -1.00026710757531 0.181906503261447 no 2814 0.158590630349812 4077 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2990 9074105 71.4286 µM -1.00240616473468 0.181350153964166 no 2815 0.158073732966949 4008 6502001
SGTC_2301 7769476 200 µM -1.00286911664551 0.18122988477718 no 2816 0.157962007627622 4119 977820
SGTC_1949 st076024 69.1 µM -1.00301741622842 0.181191368944129 no 2817 0.15792622908643 4018 2921930
SGTC_1515 3460-0031 42.1 µM -1.00377560206336 0.180994535772623 no 2818 0.157743393427616 4027 2876596
SGTC_480 am 92016 50 µM -1.00644444889203 0.18030274097625 no 2819 0.157100910562777 4070 2129 K+ channel blocker.
SGTC_2682 pyrogallin 40.03 µM -1.00683812062984 0.180200837489998 no 2820 0.15700628614696 4094 822798 An ATP competetive kinase inhibitor.
SGTC_141 0443-0274 32.331 µM -1.00727758641569 0.180087122743516 no 2821 0.156900698796907 4101 1627241
SGTC_1030 k029-0042 36.7 µM -1.0074332724081 0.180046848748437 no 2822 0.156863304429248 4080 6080581
SGTC_2849 9019321 12.99 µM -1.00768804797014 0.179980953736476 no 2823 0.156802122294341 4119 16489627
SGTC_3346 9158254 43.5805 µM -1.00846918654082 0.179779014894105 no 2824 0.156614636556201 4102 17639500
SGTC_1466 k213-0079 57.5 µM -1.00872483204295 0.179712956705333 no 2825 0.156553309615809 4011 3657981
SGTC_1608 st001473 40.5 µM -1.00879464296885 0.179694920379581 no 2826 0.156536565382952 4069 7292267
SGTC_2190 6049624 200 µM -1.00891797001466 0.179663060427788 no 2827 0.156506988127207 3967 2265554
SGTC_2945 9067681 61.76 µM -1.00950958710709 0.179510273141233 no 2828 0.156365153062845 4164 16456930
SGTC_3243 9134147 49.47 µM -1.01286151668551 0.178646167924274 no 2829 0.155563156100949 4166 24282180
SGTC_3250 9135583 49.47 µM -1.01591442834012 0.177861430764922 no 2830 0.154835068731672 4149 7699353
SGTC_2661 dactinomycin 12.96 µM -1.01624867411166 0.177775646644713 no 2831 0.154755491567224 4066 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1448 4255-0083 152 µM -1.01743508012901 0.17747136653307 no 2832 0.15447325047857 4191 5399660
SGTC_2687 chenodiol 100 µM -1.01749193055726 0.177456794239851 no 2833 0.154459734545355 4199 5702181 A cholesterol synthesis inhibitor.
SGTC_257 daunorubicin 18.5 µM -1.01753310077344 0.177446241678134 no 2834 0.154449947000015 4120 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_214 4373-3496 70 µM -1.01771374859708 0.17739994353591 no 2835 0.154407005781908 4176 3779166
SGTC_2438 5259590 200 µM -1.01784561719812 0.177366151812673 no 2836 0.154375664701645 4124 1201127
SGTC_1042 0350-0096 82 µM -1.02096278577633 0.176568551783759 no 2837 0.153636035204383 4094 3122515
SGTC_1157 4092-0394 27.6 µM -1.0211094623298 0.176531077141985 no 2838 0.153601290265089 4205 3659885
SGTC_1617 st002906 78 µM -1.02229997431153 0.176227097351904 no 2839 0.153319472698671 4102 5150859
SGTC_1307 1187-1599 12.2 µM -1.02247299123099 0.17618294760303 no 2840 0.153278544724396 4088 1538471
SGTC_1015 4130-4525 82 µM -1.02343684914599 0.175937122436857 no 2841 0.153050672061495 4119 1363237
SGTC_190 3970-0790 3.722 µM -1.02498892190414 0.175541733946825 no 2842 0.152684207422331 4018 2832352
SGTC_1822 st052468 42 µM -1.02549802703271 0.175412162838056 no 2843 0.152564127935826 4118 2873678
SGTC_2092 5303694 80.6725 µM -1.02589524090606 0.175311111017915 no 2844 0.152470483076583 4108 1963699
SGTC_673 1082-0474 110 µM -1.02597557832905 0.175290677542588 no 2845 0.152451547826162 4122 3098046
SGTC_525 k781-2675 26.7 µM -1.02620056667918 0.175233460768232 no 2846 0.152398527162165 4079 3651118 YDL195W SEC31
SGTC_3211 9128781 49.47 µM -1.02877822175147 0.174578782805124 no 2847 0.151791951403069 4136 17194361
SGTC_1940 st075990 51.1 µM -1.03145942932751 0.173899454699572 no 2848 0.151162712091528 4219 1084979
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.03191692828015 0.173783707914384 no 2849 0.151055517498026 4191 6710655
SGTC_930 2810-3379 265 µM -1.03517714865412 0.172960294724839 no 2850 0.150293094262954 4165 1015764
SGTC_706 4262-0057 46.9 µM -1.03574471322029 0.172817202992964 no 2851 0.150160628222531 4124 883298
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.0366148151484 0.172597983490525 no 2852 0.1499577029936 4144 551469
SGTC_1775 st081588 35.1725 µM -1.03819816821222 0.172199517683142 no 2853 0.149588902647582 4128 1426443 YGL099W LSG1
SGTC_495 decylubiquinone 155 µM -1.03854952011796 0.172111176293705 no 2854 0.149507146611024 4195 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2168 5727979 200 µM -1.04029354297604 0.171673100007062 no 2855 0.149101771585356 4018 695210
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.04050568488067 0.171619861302339 no 2856 0.149052512136664 4125 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1320 1313-0481 95.3 µM -1.04322606204994 0.17093809602506 no 2857 0.148421802836806 4122 6813365 YLR208W SEC13
SGTC_3032 9089427 49.47 µM -1.04365128491396 0.170831685920174 no 2858 0.148323378041982 4151 17173707
SGTC_1262 0737-0114 49.6 µM -1.04543774185674 0.170385096379485 no 2859 0.147910350435539 4210 765919
SGTC_496 calpeptin 138 µM -1.04804353450542 0.169735026386656 no 2860 0.147309274845933 4156 73364 A calpain inhibitor.
SGTC_1956 st077085 54 µM -1.04921409357069 0.169443524172749 no 2861 0.147039796773032 4186 24208685
SGTC_747 3448-8087 38.7 µM -1.05220574915338 0.168699978312909 no 2862 0.146352581183576 4187 5168703
SGTC_680 0417-1641 114 µM -1.0529957965553 0.168503970529363 no 2863 0.146171459294996 4115 2835990
SGTC_2253 7938677 135.83 µM -1.05376139112521 0.168314169153813 no 2864 0.14599608702248 4212 2301972
SGTC_1477 0139-0234 16 µM -1.05617616323187 0.167716415347373 no 2865 0.145443869445566 4159 620880
SGTC_1565 sinapyl alcohol 95.1 µM -1.05625789328124 0.167696207799805 no 2866 0.145425203775766 4186 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2992 9074591 71.4286 µM -1.05701559165225 0.167508943450989 no 2867 0.145252235838115 4111 17741321
SGTC_123 0083-0120 66.675 µM -1.05887756047019 0.167049332383648 no 2868 0.144827772466415 4118 16001701
SGTC_950 1165-0508 94.1 µM -1.0605278221776 0.166642659821271 no 2869 0.144452269733737 4172 6148369
SGTC_2468 5987765 72.9 µM -1.06060285369872 0.166624185066352 no 2870 0.144435212568642 4191 26772094
SGTC_1092 toremifene 6.32 µM -1.06068792016283 0.166603241040681 no 2871 0.144415875768373 4139 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2072 5231554 129 µM -1.0607139089774 0.16659684273108 no 2872 0.144409968494281 4186 789545
SGTC_406 estrone 100 µM -1.06094795065885 0.166539230043969 no 2873 0.144356778007438 4147 5870 A steroid.
SGTC_1513 0337-0559 19 µM -1.06099838993659 0.166526815383388 no 2874 0.144345316438306 4121 775073
SGTC_1229 0139-0193 12.2 µM -1.06107736226785 0.166507379058976 no 2875 0.144327372392794 4238 3090752
SGTC_1104 tacrolimus 29.8 µM -1.06398872923215 0.165791868396202 no 2876 0.143666902676831 4199 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3097 9117246 49.47 µM -1.064764040605 0.165601660020756 no 2877 0.143491360797024 4171 16423892
SGTC_679 0422-0091 41.4 µM -1.06477474937755 0.16559903380899 no 2878 0.143488937187895 4163 627384 YHR062C RPP1
SGTC_2924 9010168 62.78 µM -1.0657228966222 0.165366617620206 no 2879 0.143274462064682 4244 2993929
SGTC_348 k064-0012 10.7 µM -1.06599746583602 0.165299352806912 no 2880 0.143212393734463 4077 5066323
SGTC_2419 paclitaxel 166.5 µM -1.06669248717626 0.165129163478698 no 2881 0.143055360382517 4088 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_800 3448-7362 155 µM -1.06690080559984 0.165078174811893 no 2882 0.143008315517728 4227 15991913
SGTC_1120 ficusin 1.78878 µM -1.0675289604142 0.164924487393783 no 2883 0.142866521656472 4204 6199 A DNA cross-linker.
SGTC_2352 9027995 87.8 µM -1.06771646258384 0.164878630162091 no 2884 0.142824215071091 4121 2997347
SGTC_1931 st074438 57.1 µM -1.06781285649403 0.164855058407137 no 2885 0.142802468767135 4130 2787313
SGTC_932 2857-0803 154 µM -1.0734521766521 0.163479842633962 no 2886 0.141534142429818 4222 674898
SGTC_370 0180-0345 38.7 µM -1.07794019680797 0.162390724943635 no 2887 0.140530222652652 4028 3989527
SGTC_1393 3470-5649 58.2 µM -1.0779490507463 0.16238858101718 no 2888 0.140528246915578 4145 4108395
SGTC_17 0960-0276 49.807 µM -1.0794499483327 0.162025414205864 no 2889 0.140193597395296 4155 6821114
SGTC_3309 9129340 25.759 µM -1.07949227820612 0.162015179474148 no 2890 0.140184167117181 4196 17158987
SGTC_2931 9014674 55.67 µM -1.08175652293727 0.161468332604902 no 2891 0.139680365040798 4133 2996810
SGTC_2091 4-phenylthiadiazole 200 µM -1.08180695889838 0.161456165331552 no 2892 0.13966915690378 4183 270010
SGTC_2811 7967822 32.47 µM -1.08391570948843 0.16094798114814 no 2893 0.139201086800562 4233 2232244
SGTC_1056 3448-1962 115 µM -1.08448692286363 0.160810505320073 no 2894 0.139074481035171 4177 715507
SGTC_1777 st045864 34.765 µM -1.08472444138078 0.160753363520968 no 2895 0.13902185966513 4167 4691462
SGTC_753 1322-0200 289 µM -1.08577243874927 0.160501396433053 no 2896 0.13878984148285 4251 5403907
SGTC_2606 farnesol 9.78 µM -1.08626582227283 0.160382862982858 no 2897 0.138680701696676 4225 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2732 terfenadine 20 µM -1.08769593764093 0.160039606685087 no 2898 0.138364680856115 4240 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_802 4112-3352 742 µM -1.08847030358424 0.159853943994743 no 2899 0.138193769747352 4243 704594
SGTC_2755 lomerizine 42.69 µM -1.08905224419903 0.159714510141755 no 2900 0.138065423801555 4152 3949 A calcium channel blocker.
SGTC_1807 st050092 58.9 µM -1.08968087104993 0.159563979634712 no 2901 0.137926872653113 4204 5008496
SGTC_929 2805-0021 398 µM -1.09496858475584 0.158301464543429 no 2902 0.136765199897611 4257 3098024
SGTC_215 1287-0124 461.5 µM -1.0963768310331 0.157966334448528 no 2903 0.136456949455533 4208 5560863
SGTC_3141 9094609 49.47 µM -1.09645033794312 0.157948854302656 no 2904 0.136440872619048 4154 25236309 YDL196W YDL196W
SGTC_549 1661-1316 519 µM -1.09672066484667 0.157884580743781 no 2905 0.136381760050535 4222 2857282
SGTC_1677 st019204 53.9 µM -1.09756572194569 0.157683768764251 no 2906 0.136197083840186 4228 3945625
SGTC_1669 st015249 58.4 µM -1.09910722171429 0.157317892612949 no 2907 0.135860650146807 4271 722793
SGTC_483 fpl-64176 144 µM -1.10068460434125 0.156944077833677 no 2908 0.135516974554783 4285 3423
SGTC_1921 5740136 50 µM -1.10481340672574 0.155968385672308 no 2909 0.134620225017864 4160 1774243
SGTC_3147 9097027 49.47 µM -1.10645954175017 0.155580498743626 no 2910 0.134263833143885 4191 25236841
SGTC_2011 4012611 177 µM -1.1064948141324 0.155572194307333 no 2911 0.13425620369297 4192 2049887
SGTC_2885 9057732 51.95 µM -1.10702558625851 0.155447266028267 no 2912 0.134141433112061 4263 6471414
SGTC_858 0438-0351 2.77 µM -1.1073850308857 0.155362700847252 no 2913 0.134063747520115 4178 2799119
SGTC_2677 mitomycin C 100 µM -1.11004013504181 0.154738985027319 no 2914 0.133490866013036 4247 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1150 3909-7983 10.9 µM -1.1103034833304 0.154677211663947 no 2915 0.133434136295524 4183 23965914
SGTC_1770 st043884 66.3 µM -1.11035543166673 0.154665028115496 no 2916 0.133422947695474 4201 670149
SGTC_380 3970-0968 6 µM -1.11063252420303 0.154600051755073 no 2917 0.133363278580674 4083 2891601
SGTC_600 1495-0418 41.6 µM -1.11272487894786 0.154109990965388 no 2918 0.132913303535998 4197 5377768
SGTC_3267 9137951 49.47 µM -1.11544702326348 0.153473963804263 no 2919 0.132329454185501 4242 16643986
SGTC_1743 st037606 46.3785 µM -1.11906264364454 0.152631868497015 no 2920 0.131556707606877 4186 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_176 1486-1328 72.834 µM -1.1190956981457 0.152624184112063 no 2921 0.131549657448222 4280 22310231
SGTC_869 0564-0080 44.1 µM -1.12000982679204 0.152411772652607 no 2922 0.131354787268058 4210 6843321
SGTC_1081 sertraline 6 µM -1.12066234578321 0.152260270175498 no 2923 0.131215807934558 4201 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2061 5245884 80.95 µM -1.12168299741869 0.152023494879102 no 2924 0.13099862414343 4189 573863
SGTC_2377 9073351 62.6 µM -1.12405816187037 0.15147344089954 no 2925 0.130494176368645 4179 7337946 YHR072W ERG7
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.12542453560141 0.151157608694518 no 2926 0.130204589436831 4268 23665772 A membrane-active detergent.
SGTC_1367 1812-0510 76.9 µM -1.12734978250787 0.150713339110536 no 2927 0.129797311031631 4250 1142582 YDR527W RBA50
SGTC_1050 3232-1156 69.3 µM -1.1276833985412 0.150636442418626 no 2928 0.129726825647715 4208 700529
SGTC_3273 9137859 49.47 µM -1.12787253983209 0.15059285798158 no 2929 0.12968687622588 4306 2377234
SGTC_2760 etidronate 98.04 µM -1.13012057231146 0.150075479788216 no 2930 0.129212711126564 4174 3305 A chelator and antioxidant.
SGTC_2781 5567276 71.43 µM -1.13273981779289 0.149474164404409 no 2931 0.128661765581587 4247 2853274
SGTC_82 0054-0107 293.755 µM -1.13429263966562 0.14911843439356 no 2932 0.128335907780647 4182 3104697
SGTC_2943 9068529 45.32 µM -1.13659152159369 0.148592831354847 no 2933 0.127854543012352 4212 3270634
SGTC_77 0828-0286 12.516 µM -1.13758670726136 0.148365682491691 no 2934 0.127646549898591 4127 745345
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.13883595049239 0.148080874490209 no 2935 0.127385792047467 4213 688803
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.14065697397808 0.147666365310781 no 2936 0.127006349010327 4322 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_963 1269-2853 151 µM -1.14089617455864 0.14761197524787 no 2937 0.126956565773351 4214 3668223
SGTC_37 0566-0070 1.56 µM -1.140933685057 0.147603447228497 no 2938 0.126948760193227 4167 1626686
SGTC_1300 1094-0077 113 µM -1.14142916266536 0.147490831265049 no 2939 0.126845687333767 4209 5532636
SGTC_3037 9091026 49.47 µM -1.14171105426893 0.147426786470896 no 2940 0.126787072199683 4153 25236398 YIL048W NEO1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.14241117136636 0.147267802920247 no 2941 0.126641574935523 4272 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.14282204026501 0.147174555774395 no 2942 0.126556242955446 4276 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2867 9039098 71.43 µM -1.14385993775699 0.146939180117228 no 2943 0.126340863910515 4198 6463460
SGTC_2016 5121758 140 µM -1.14400386119614 0.146906560927614 no 2944 0.126311017849932 4158 2795203
SGTC_983 1491-0821 12.2 µM -1.14631213270532 0.146384071753516 no 2945 0.125833012284334 4231 46495113
SGTC_994 3910-0338 138 µM -1.14686618407357 0.146258845269579 no 2946 0.125718465249104 4305 3479481
SGTC_1434 4073-0095 163 µM -1.14918837957337 0.145734766340831 no 2947 0.125239155727497 4215 24133745
SGTC_2442 5158906 48.48 µM -1.14927896526007 0.145714348348934 no 2948 0.125220484407302 4244 1893835
SGTC_2267 7931562 200 µM -1.15024900233932 0.145495822784203 no 2949 0.125020664366202 4173 934880
SGTC_79 0052-0007 94.094 µM -1.15056128251134 0.14542552064084 no 2950 0.12495638451382 4244 2801472
SGTC_2917 7979103 53.79 µM -1.15072204758297 0.145389337278691 no 2951 0.124923301583028 4271 2980565
SGTC_2243 6634756 200 µM -1.15097648106837 0.145332084362844 no 2952 0.124870955668076 4296 885676
SGTC_48 0382-0018 55 µM -1.15277385110703 0.144928070135284 no 2953 0.12450160995491 4315 762596
SGTC_416 estradiol valerate 100 µM -1.15355792996776 0.144752061385287 no 2954 0.124340727292776 4268 13791 A steroid.
SGTC_625 k213-0058 121 µM -1.15504389967434 0.144418888404002 no 2955 0.124036224872466 4306 3655420
SGTC_1068 loratadine 26.9 µM -1.15590450586786 0.144226166240367 no 2956 0.123860109698663 4280 3957 A H1 histamine antagonist.
SGTC_447 ml7 120 µM -1.15825782946495 0.143700053979509 no 2957 0.123379417553045 4287 4216 Selective myosin light chain kinase inhibitor.
SGTC_1668 st014914 51.6 µM -1.16021351818592 0.143263824031012 no 2958 0.122980942240574 4255 2839556
SGTC_1773 st048542 73.5835 µM -1.16041417182049 0.143219117486442 no 2959 0.12294010977179 4208 3237138
SGTC_2624 nerol 100 µM -1.16076984292569 0.143139895499367 no 2960 0.122867755028817 4155 637566 A natural product oil.
SGTC_2904 7225135 42.03 µM -1.16131946606872 0.14301753096994 no 2961 0.122756003046166 4340 4446116
SGTC_2455 5377712 9.75 µM -1.16345800939659 0.142542092224969 no 2962 0.122321862668243 4237 2243908
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.16521493070943 0.142152295956877 no 2963 0.121966001703168 4265 2374 Ca(2+)-ATPase inhibitor.
SGTC_1629 st005085 44.9 µM -1.16531513653869 0.142130085733103 no 2964 0.121945727150614 4204 24207091
SGTC_3094 9117742 49.47 µM -1.16632629111865 0.141906098764769 no 2965 0.121741273639707 4191 17149698
SGTC_1814 st052110 31.539 µM -1.17035338283775 0.141016405645075 no 2966 0.120929393707295 4198 674163
SGTC_2818 7996756 12.99 µM -1.17071394613633 0.140936932423223 no 2967 0.120856888784094 4288 2241621
SGTC_597 k018-0003 82.8 µM -1.17180832705031 0.140695901557176 no 2968 0.120637009372422 4322 6786234
SGTC_1394 3474-0001 65.7 µM -1.17964366366281 0.138978388318984 no 2969 0.119070984509303 4249 5017666 YIL048W NEO1
SGTC_1763 st044482 94.5 µM -1.18143151355202 0.138588498513591 no 2970 0.118715672601305 4251 88505
SGTC_667 1498-1044 59 µM -1.18410143712903 0.138007636885639 no 2971 0.118186455659441 4274 6739982
SGTC_2681 menadione 3.18 µM -1.1844787768474 0.137925677954846 no 2972 0.118111796304621 4282 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2982 9019404 25.97 µM -1.18487323430276 0.137840036520421 no 2973 0.118033785749444 4218 22333232
SGTC_317 4495-0002 170 µM -1.18498117006698 0.13781660869754 no 2974 0.11801244600001 4288 15991618
SGTC_3227 9130768 49.47 µM -1.18511942723391 0.137786603480606 no 2975 0.117985115457739 4328 17720899
SGTC_88 0180-0332 8.668 µM -1.18796879502498 0.137169212826243 no 2976 0.117422851979841 4352 3101745
SGTC_300 r073-0011 5.04 µM -1.18903335177015 0.136939034188934 no 2977 0.117213271487897 4280 2735780
SGTC_1985 st071382 65.5 µM -1.18928571192247 0.136884507561624 no 2978 0.117163627935803 4265 6123237
SGTC_93 0109-0045 59.227 µM -1.19011410834783 0.136705622987873 no 2979 0.117000772916157 4401 88733
SGTC_1458 k015-0034 6.33 µM -1.19264573066371 0.136159933370707 no 2980 0.116504073955167 4302 3598957
SGTC_596 1155-0152 116 µM -1.19510363875817 0.135631560902461 no 2981 0.116023270249005 4286 280313
SGTC_2049 5262831 67.185 µM -1.19622567391721 0.13539082641976 no 2982 0.115804252247353 4265 763417
SGTC_3319 9138450 16.7555 µM -1.1976496630598 0.135085729105305 no 2983 0.11552671668445 4220 2029690
SGTC_2600 tangeritin 87.95 µM -1.19826859153255 0.134953267466277 no 2984 0.115406234951036 4203 68077 A bioactive flavone.
SGTC_3087 9117406 49.47 µM -1.19900325955341 0.134796151193638 no 2985 0.115263339084279 4317 42546093
SGTC_1286 0929-0070 131 µM -1.19963743545387 0.134660627154497 no 2986 0.115140090517086 4363 1420408
SGTC_1539 benzyladenosine 56 µM -1.20007824311584 0.134566481213111 no 2987 0.115054477212989 4277 92208 A nucleotide analog.
SGTC_3192 9110362 49.47 µM -1.2012067261275 0.134325670232219 no 2988 0.114835510473344 4302 16649480
SGTC_1063 disulfiram 1.84 µM -1.20567648062572 0.133374761917337 no 2989 0.113971128510629 4321 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.20725758340061 0.133039505044262 no 2990 0.113666480207758 4357 165506
SGTC_168 3970-0862 530.542 µM -1.20755206525648 0.132977127278992 no 2991 0.113609803368147 4252 3135186
SGTC_2334 9017922 200 µM -1.20993368901802 0.132473386618175 no 2992 0.113152169389644 4340 3163164
SGTC_2293 7624732 200 µM -1.21011303142099 0.13243550695652 no 2993 0.113117761701029 4186 894453
SGTC_1430 4049-0248 69.1 µM -1.21046643402573 0.132360885156508 no 2994 0.113049981591575 4309 22774488
SGTC_532 1548-0774 215 µM -1.21090731310644 0.132267833123264 no 2995 0.112965464755153 4394 5932993
SGTC_2310 7668677 200 µM -1.21172234976705 0.132095930070395 no 2996 0.11280934041159 4310 2197143
SGTC_2618 avocadyne 43.43 µM -1.21229539000079 0.131975159846131 no 2997 0.112699663963211 4213 3015189
SGTC_1325 1431-0015 227 µM -1.21507694232302 0.131390020110655 no 2998 0.112168373435674 4305 1103340
SGTC_639 0833-0042 114 µM -1.21673051007424 0.131043018406273 no 2999 0.111853383372885 4305 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_779 1360-0071 233 µM -1.2182713441769 0.130720244229214 no 3000 0.111560437916907 4342 7566
SGTC_618 k072-0232 33.2 µM -1.21870397326332 0.130629715921554 no 3001 0.111478284689466 4353 5872756 YGL099W LSG1
SGTC_1986 st071812 45 µM -1.22139557924708 0.130067466984431 no 3002 0.110968140096869 4246 11838594
SGTC_3279 9140807 49.47 µM -1.22196057994901 0.129949657132016 no 3003 0.110861267249897 4341 45595718
SGTC_119 0121-0043 24.815 µM -1.22675434042663 0.128953068957587 no 3004 0.109957468421856 4314 1092378
SGTC_1982 st072467 71.9 µM -1.22836899024391 0.128618591383668 no 3005 0.109654241609383 4284 3163533
SGTC_2224 6650123 117.647 µM -1.22927546742613 0.128431077123985 no 3006 0.109484271038806 4320 2908370
SGTC_1165 k072-0275 30.3 µM -1.23158904133426 0.127953350796201 no 3007 0.109051318301899 4279 6153523 YGL055W OLE1
SGTC_195 4234-0266 16.654 µM -1.2328816159243 0.127686987288553 no 3008 0.10880996764957 4333 2303354
SGTC_724 3910-0327 137 µM -1.23339834653572 0.127580611466726 no 3009 0.108713590798028 4350 2885483
SGTC_1841 st054148 70 µM -1.2336718489361 0.127524332328754 no 3010 0.108662603963743 4336 675442
SGTC_2098 5376439 882.5 nM -1.23496263296495 0.127258958099155 no 3011 0.108422205679745 4346 2844116
SGTC_2710 st078562 53.7235 µM -1.2350773862382 0.127235384409782 no 3012 0.108400852329903 4250 17250908
SGTC_768 0384-0033 77.3 µM -1.23704061445339 0.126832550266943 no 3013 0.108036002417074 4270 3965305 YMR134W ERG29
SGTC_1904 st060225 78 µM -1.23894181419391 0.126443290844285 no 3014 0.107683523492545 4275 66595
SGTC_879 0831-1030 162 µM -1.24734621544704 0.124732514898173 no 3015 0.106135289257256 4332 1549252
SGTC_841 0251-0215 91.2 µM -1.25256836629187 0.123677693025312 no 3016 0.105181416650549 4354 3888614
SGTC_2203 7227154 166.4 µM -1.26007968712326 0.122171460297503 no 3017 0.103820308583754 4352 896304
SGTC_2017 5132927 60.65 µM -1.26207608333733 0.121773301849379 no 3018 0.103460705172163 4319 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1474 0330-0125 5.35 µM -1.26278085954888 0.121632960252537 no 3019 0.103333972619893 4373 X1474
SGTC_187 1488-2104 32.728 µM -1.26323426302827 0.121542734440791 no 3020 0.103252501399489 4331 2852859
SGTC_1031 k035-0009 16 µM -1.26543235517064 0.121105988178072 no 3021 0.102858191445951 4377 5180959
SGTC_247 mechlorethamine 29.705 µM -1.26613135495973 0.120967333215976 no 3022 0.102733029299634 4278 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_756 0508-1999 28.3 µM -1.26630582154005 0.120932743110454 no 3023 0.102701806770637 4358 6753853
SGTC_1046 2001-0062 216 µM -1.26641680634659 0.120910742655173 no 3024 0.102681948525513 4268 739778
SGTC_2653 dihydrofissinolide 100 µM -1.27072197339945 0.120059504609273 no 3025 0.101913787784577 4387 6857746
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.27256449896376 0.119696485379185 no 3026 0.101586311449624 4333 15053
SGTC_286 k060-0067 22.9 µM -1.27305671119523 0.119599639584817 no 3027 0.101498959265276 4376 5985051
SGTC_2125 5246583 200 µM -1.27338632584832 0.119534816774143 no 3028 0.101440493626738 4368 835267
SGTC_1631 benzylvanillin 81.9 µM -1.27415092905672 0.119384543507693 no 3029 0.101304966036003 4392 75506
SGTC_2123 5259487 200 µM -1.27743639521538 0.118740343134206 no 3030 0.100724111218976 4371 2173474
SGTC_14 0354-0009 295 µM -1.27919584613029 0.118396368845691 no 3031 0.100414049132746 4438 1713507
SGTC_136 0097-0015 404.482 µM -1.28010324079282 0.118219247907481 no 3032 0.100254414525852 4353 4861337
SGTC_2597 laccaic acid a 100 µM -1.28072490194165 0.118098009567773 no 3033 0.10014515494273 4344 5491415 A textile dye.
SGTC_731 3966-0296 387 µM -1.28096921223657 0.118050387473211 no 3034 0.10010224017536 4353 660956
SGTC_2793 7325131 81.82 µM -1.28154479787332 0.11793824535474 no 3035 0.100001187720172 4288 4176441
SGTC_2140 5586273 200 µM -1.28248223582929 0.117755764431628 no 3036 0.0998367663049542 4319 854421
SGTC_6 0844-0013 19.835 µM -1.28606986330986 0.117059245625107 no 3037 0.0992093403127198 4490 1584900
SGTC_2892 9047358 58.44 µM -1.28918517104258 0.116456797441576 no 3038 0.0986668595424287 4355 6466771
SGTC_456 gingerol 170 µM -1.29002983051611 0.116293834144647 no 3039 0.098520150504761 4411 442793 A herb.
SGTC_1954 st077032 68.9 µM -1.2939535692602 0.115538934350085 no 3040 0.0978407295764865 4315 698907
SGTC_2952 9073731 13.78 µM -1.29399514559029 0.115530954041068 no 3041 0.0978335487989794 4374 16457353
SGTC_842 0271-0008 11.1 µM -1.29621572950811 0.115105296155737 no 3042 0.0974505859344252 4398 1221709
SGTC_2465 5809242 33.21 µM -1.29801303047282 0.114761593710084 no 3043 0.0971414286817503 4420 2731748
SGTC_872 0588-0139 234 µM -1.29952297102594 0.114473408834247 no 3044 0.0968822577188399 4321 2047100
SGTC_1902 st060212 70.5 µM -1.30082161098435 0.114225964822693 no 3045 0.096659761450014 4370 688944
SGTC_752 1896-0090 130 µM -1.30148039110031 0.114100586003373 no 3046 0.0965470360997875 4363 772567
SGTC_2803 7707263 71.43 µM -1.30168717612971 0.114061250965309 no 3047 0.0965116725704821 4334 2199229
SGTC_2394 5221648 200 µM -1.30217497955948 0.113968498351694 no 3048 0.096428288130183 4399 788586
SGTC_405 ebelactone b 50 µM -1.30361371195416 0.113695245873707 no 3049 0.0961826615508937 4298 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3317 9138495 8.753 µM -1.30394080791854 0.1136331871047 no 3050 0.0961268825486298 4280 17020139
SGTC_819 1013-0258 27.7 µM -1.30506361062418 0.113420345420542 no 3051 0.0959355942415961 4363 5753198
SGTC_381 3461-2219 42.7 µM -1.30975362792246 0.112534366822951 no 3052 0.0951395975593659 4364 2883159
SGTC_629 3448-6466 76.7 µM -1.31042420714341 0.11240809455557 no 3053 0.0950261844664896 4377 573744
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.31059703677861 0.11237556658177 no 3054 0.0949969704455213 4334 2333 A French combination drug.
SGTC_1826 st055655 41.6 µM -1.31151318803785 0.11220325161463 no 3055 0.0948422205526545 4388 676168
SGTC_775 4577-0580 57.3 µM -1.31206417254963 0.112099710281476 no 3056 0.094749241576522 4406 2006902
SGTC_147 4466-0538 29.23 µM -1.31475980844424 0.111594129300304 no 3057 0.0942953194903691 4461 6742687 YHR072W ERG7
SGTC_1486 3970-0793 4.53 µM -1.31620905215743 0.111322991185686 no 3058 0.094051943140586 4411 2844330
SGTC_2265 7929201 200 µM -1.31689238940453 0.111195309769267 no 3059 0.0939373489520914 4361 1265108
SGTC_2418 pentamidine 31.67 µM -1.32240077406163 0.110169897378926 no 3060 0.0930173656248204 4330 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1505 k297-0037 20.6 µM -1.32434395605431 0.109809788112786 no 3061 0.0926944191853149 4373 4089396
SGTC_3156 9099931 49.47 µM -1.32484902901253 0.10971632680042 no 3062 0.0926106147082752 4427 18111053
SGTC_3121 9125696 49.47 µM -1.32601543126411 0.10950070794111 no 3063 0.0924172930348922 4491 1235365
SGTC_472 calcifediol 10 µM -1.32740827764307 0.109243627929801 no 3064 0.0921868314835996 4431 5283731 A vitamin D metabolite.
SGTC_1526 st051518 75 µM -1.32766725810812 0.109195875317273 no 3065 0.0921440273002032 4373 673993
SGTC_2250 alverine citrate 130 µM -1.32929097667663 0.108896824616097 no 3066 0.0918759950315744 4264 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1819 st053448 58.6 µM -1.32963725503348 0.108833124546885 no 3067 0.0918189085690941 4301 2857616
SGTC_1667 st014849 34.6 µM -1.33448546544954 0.107944078036624 no 3068 0.0910224035578196 4461 5348460
SGTC_422 cantharidin 155 µM -1.34832596257745 0.105434865074319 no 3069 0.0887767826168343 4311 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_340 k038-0059 454 µM -1.35239095896962 0.104705980499762 no 3070 0.0881251400625854 4368 23733424
SGTC_2423 st077119 87.2 µM -1.35597952983102 0.104065561481418 no 3071 0.0875528406004395 4337 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3002 9075603 71.4286 µM -1.3586349518148 0.103593504556513 no 3072 0.0871311469508411 4356 20105405
SGTC_3335 9143315 29.6265 µM -1.35923845348473 0.103486436525818 no 3073 0.0870355198935241 4416 4899691
SGTC_114 0364-0001 490.298 µM -1.36015658159114 0.103323704274958 no 3074 0.0868901894955052 4434 4003655
SGTC_703 3875-0075 71.8 µM -1.36396870634913 0.102650016928921 no 3075 0.0862887074691914 4456 2850814
SGTC_53 0973-0023 39.979 µM -1.3642991916712 0.102591763555695 no 3076 0.0862367101063709 4302 674768
SGTC_460 trequinsin 123 µM -1.36894157114002 0.101776007635657 no 3077 0.0855087698766266 4502 5537 A vasodilator.
SGTC_2792 7535235 81.82 µM -1.37241872617321 0.101168104382563 no 3078 0.0849665619297109 4389 1281891
SGTC_849 0386-0493 241 µM -1.37258277761416 0.101139489141588 no 3079 0.0849410444842545 4434 726119
SGTC_337 1315-0038 354 µM -1.37361368185557 0.100959805087375 no 3080 0.0847808235451488 4386 1626437
SGTC_1824 st053723 68.6 µM -1.37609278594046 0.100528656352063 no 3081 0.0843964543619978 4437 675225
SGTC_2153 5569715 200 µM -1.37644495908213 0.100467517949654 no 3082 0.0843419584112279 4434 2054701
SGTC_1224 0823-0416 294 µM -1.3765339961995 0.100452065114042 no 3083 0.0843281848189215 4446 3598164
SGTC_922 1866-0035 480 µM -1.37673846647397 0.100416584842958 no 3084 0.0842965606894689 4351 3156169
SGTC_3036 9090181 49.47 µM -1.37909066067894 0.100009082845104 no 3085 0.0839334014996955 4474 25236586
SGTC_613 3914-0030 117 µM -1.37956308675018 0.099927383998189 no 3086 0.0838606047407224 4143 1145395
SGTC_1888 azatryptophan 97.5 µM -1.3803387703477 0.0997933471472564 no 3087 0.0837411814903486 4465 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2414 st077232 92.9 µM -1.38145115060716 0.0996013589577206 no 3088 0.0835701438854664 4355 729801
SGTC_1596 piperlongumine 63 µM -1.38283175292412 0.0993634532772914 no 3089 0.0833582301704377 4454 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1581 himbacine 57.9 µM -1.38757697741024 0.0985489231613695 no 3090 0.0826329479982597 4427 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.39214290317851 0.0977697951122648 no 3091 0.081939564303008 4435 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2111 5486399 200 µM -1.39226363228409 0.0977492553929836 no 3092 0.0819212900023566 4392 689674
SGTC_1883 5-benzylidenerhodanine 20 µM -1.39254989026209 0.0977005667847141 no 3093 0.0818779725071035 4403 1273210
SGTC_1389 3405-0187 19 µM -1.39570800354753 0.0971645941872505 no 3094 0.0814012215913395 4418 799890
SGTC_977 1348-1378 135 µM -1.39619237304868 0.0970825816466073 no 3095 0.0813282864143998 4415 X977
SGTC_1602 st001878 87.6 µM -1.3996624345338 0.0964965226887833 no 3096 0.0808072139994912 4414 595405 YLR310C CDC25
SGTC_2321 7390090 138.78 µM -1.40002233948523 0.0964358874115265 no 3097 0.0807533144515694 4446 649046
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.40604647109069 0.0954251196509422 no 3098 0.0798551629391456 4483 91467 include heat shock
SGTC_2234 tolnaftate 200 µM -1.40873635453385 0.0949763205284666 no 3099 0.0794565704318627 4547 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_451 chloral hydrate 100 µM -1.4111255000606 0.0945790042110971 no 3100 0.0791038061233426 4436 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2635 hydroquinidine 100 µM -1.41289607641565 0.0942853477556634 no 3101 0.0788431414615697 4372 442912 An experimental heart treatment.
SGTC_3300 9124615 50.48 µM -1.41874773895901 0.0933196126922956 no 3102 0.0779862869338939 4468 24824903
SGTC_1275 0867-0008 21.1 µM -1.41890780870615 0.0932932984904817 no 3103 0.0779629477191564 4422 3422836
SGTC_2215 7188065 200 µM -1.4210405003564 0.0929432237850113 no 3104 0.0776524928610992 4493 940217
SGTC_1957 st077035 62.4 µM -1.42335612377241 0.0925642220932588 no 3105 0.0773164724517272 4468 705593
SGTC_3023 9089636 49.47 µM -1.42575475124924 0.0921728417637606 no 3106 0.0769695731349785 4532 17249241
SGTC_926 2268-1401 59.4 µM -1.42741800517828 0.0919021713300467 no 3107 0.0767297220144446 4426 2931578
SGTC_1664 st014217 9.02 µM -1.42803149545324 0.0918024834459347 no 3108 0.0766413966858046 4518 3982782
SGTC_2375 9072683 200 µM -1.42875109301177 0.0916856559740786 no 3109 0.0765378934626539 4503 16798029
SGTC_1419 3993-2473 62.6 µM -1.42987144568674 0.0915039847673566 no 3110 0.0763769593614215 4519 704026
SGTC_845 0330-0138 4.51 µM -1.43175407644517 0.0911993071145494 no 3111 0.0761071071456678 4400 9039800
SGTC_2459 5811157 9.22 µM -1.43435633433586 0.090779407231766 no 3112 0.0757353008827935 4408 2870684 YBR192W RIM2
SGTC_1024 4507-0395 26 µM -1.43483923124135 0.0907016451362224 no 3113 0.0756664578337172 4497 4201836
SGTC_2147 5545932 89.7195 µM -1.4352998236825 0.0906275208590265 no 3114 0.0756008389984177 4508 797404
SGTC_2110 5483698 200 µM -1.43679150661142 0.0903877692657397 no 3115 0.0753886222324801 4441 2848765 YHR062C RPP1
SGTC_250 brefeldin a 552.239 µM -1.44011726135171 0.089854931584292 no 3116 0.0749171131480276 4373 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.44039439923659 0.0898106353836185 no 3117 0.0748779236735082 4554 16725076
SGTC_2041 5107442 45.335 µM -1.44091646195327 0.0897272358317239 no 3118 0.0748041423838559 4479 793005
SGTC_3070 9117005 49.47 µM -1.44664791184321 0.0888154191002316 no 3119 0.0739977799895537 4558 8779016
SGTC_1425 4048-4433 7.33 µM -1.4471503180534 0.0887358213678363 no 3120 0.0739274138672538 4529 23734946
SGTC_952 1185-0122 232 µM -1.44847093909339 0.0885268447617997 no 3121 0.0737426938740741 4408 678600
SGTC_2216 7189485 200 µM -1.44920725584821 0.0884104884566608 no 3122 0.0736398559160876 4474 731273
SGTC_904 1141-0088 396 µM -1.45208255676386 0.0879572108551296 no 3123 0.07323932572819 4473 1378119
SGTC_901 1112-0062 60.1 µM -1.45283181111753 0.0878393795738425 no 3124 0.0731352286327039 4452 1908457
SGTC_1027 k015-0025 8.67 µM -1.45434711436279 0.0876014357264535 no 3125 0.0729250471691017 4438 3598955
SGTC_484 loperamide 105 µM -1.45435518146035 0.0876001702609229 no 3126 0.0729239294539078 4561 3955 An opioid-receptor agonist.
SGTC_2386 9075165 157.42 µM -1.45445507656793 0.0875845010941064 no 3127 0.072910089840195 4450 16452277
SGTC_1311 1190-0148 100 µM -1.45624321184569 0.0873043746654373 no 3128 0.0726626989439537 4507 1961333
SGTC_1020 4335-0961 93.3 µM -1.45756359658097 0.0870979549907255 no 3129 0.0724804349371242 4436 669075
SGTC_2236 dapsone 200 µM -1.45859511729379 0.0869369480578518 no 3130 0.0723382891467405 4487 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1632 st005650 90 µM -1.46007069722825 0.0867070159365003 no 3131 0.0721353224988216 4487 2759605
SGTC_2903 5923464 63.88 µM -1.46045603972437 0.0866470448801743 no 3132 0.0720823904252788 4486 2876576
SGTC_3241 9133421 49.47 µM -1.46228238408223 0.0863632315608425 no 3133 0.0718319218994719 4565 17018221
SGTC_372 0155-0182 15.9 µM -1.47072787110824 0.0850598405679466 no 3134 0.0706823628188628 4353 771486
SGTC_1749 st037932 54.2 µM -1.47148449438262 0.0849437944569784 no 3135 0.0705800688958456 4487 594497
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.47280660798218 0.0847413019454541 no 3136 0.0704015950200067 4440 2724 A muscle relaxant with antifungal properties.
SGTC_3102 9121669 49.47 µM -1.47709162881962 0.0840875036483169 no 3137 0.0698255385989833 4521 41905072
SGTC_2673 kobusone 100 µM -1.48205091723568 0.0833355632515104 no 3138 0.0691633736753121 4584 6710676 An epoxy ketone and protein crosslinker.
SGTC_681 1642-0006 26.6 µM -1.48669269906632 0.0826363541823984 no 3139 0.0685479959286725 4490 4446530
SGTC_296 1222-0039 74.9 µM -1.48704428641349 0.0825835736869036 no 3140 0.0685015573433256 4501 5984176
SGTC_1683 st010134 710 nM -1.4878521035972 0.0824623998394065 no 3141 0.0683949506596418 4453 3818134
SGTC_1163 k060-0048 49.9 µM -1.48831390487167 0.0823931890818002 no 3142 0.0683340648205436 4496 6809982
SGTC_954 1189-0853 2.85 µM -1.48934202856854 0.082239259942756 no 3143 0.0681986628478699 4415 2828194
SGTC_66 0109-0187 42.4 µM -1.48939718446782 0.08223100820968 no 3144 0.0681914047756259 4353 759417
SGTC_1833 st055984 71 µM -1.50084248563173 0.0805321628942338 no 3145 0.0666981534862629 4529 676288
SGTC_1873 rapamycin 2 nM -1.50230048557454 0.080317667315583 no 3146 0.0665097616577576 4460 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1080 nisoldipine 24.4 µM -1.50830619467692 0.0794386795236909 no 3147 0.0657380892564822 4507 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2777 climbazole 1.536 µM -1.50944039194136 0.0792735002757547 no 3148 0.065593138706262 4321 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1103 duloxetine 36.1 µM -1.51038113861233 0.0791366916633268 no 3149 0.0654730992914988 4556 60835 A selective serotonin reuptake inhibitor.
SGTC_1294 1000-1494 117 µM -1.52013513503125 0.0777287308705296 no 3150 0.0642385078683129 4506 712797 YDL207W GLE1
SGTC_488 nitrendipine 139 µM -1.52021087913192 0.0777178723257564 no 3151 0.064228992016273 4532 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3330 9141424 71.43 µM -1.52247862690422 0.0773933049500928 no 3152 0.0639445983956004 4521 27261020
SGTC_1221 2958-7315 257 µM -1.52290994036418 0.0773316906697348 no 3153 0.0638906192571263 4526 4562705
SGTC_428 3448-4153 16.5 µM -1.52376095243407 0.0772102306186293 no 3154 0.0637842185335758 4468 3834874
SGTC_2826 7992541 19.48 µM -1.52599331502183 0.0768923071819701 no 3155 0.0635057646754917 4510 2985066
SGTC_2749 bexarotene 57.39 µM -1.52738419940551 0.0766947272153373 no 3156 0.0633327515667983 4497 82146 An retinoic acid receptor inhibitor.
SGTC_274 sirtinol 40.1 µM -1.52954908521614 0.0763879661106987 no 3157 0.0630641901884328 4544 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2227 7312221 64.1025 µM -1.53460316123757 0.0756754457655695 no 3158 0.0624406678408109 4610 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3074 9116018 49.47 µM -1.53883261828952 0.075083080453808 no 3159 0.0619225822548305 4557 17027303
SGTC_3245 9134821 49.47 µM -1.54036336685436 0.0748695619981599 no 3160 0.0617359028441882 4517 17014901
SGTC_3191 9110352 49.47 µM -1.54134553176059 0.0747328075993977 no 3161 0.0616163564504357 4465 17122424
SGTC_2541 muurolladie-3-one 83.07 µM -1.54246008487281 0.0745778507369489 no 3162 0.0614809151674799 4454 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_675 1309-0189 238 µM -1.54549381776416 0.0741573116223348 no 3163 0.0611134315637474 4521 4246530
SGTC_1836 st055642 81 µM -1.54799098530767 0.0738125128463436 no 3164 0.0608122334642384 4509 8571
SGTC_227 fluconazole 33.516 µM -1.54802936687466 0.0738072228524215 no 3165 0.0608076131115923 4523 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1135 dihydrocapsaicin 536.708 nM -1.55106870496444 0.0733892410639185 no 3166 0.0604426099790755 4432 107982 A Capsaicinoid.
SGTC_2486 5283202 22.39 µM -1.55387088440711 0.0730054805849027 no 3167 0.0601076089973881 4524 1377751
SGTC_2770 toltrazuril 17.5 µM -1.55423270171746 0.0729560416108887 no 3168 0.0600644598609777 4452 68591 Kills coccidiodes.
SGTC_1610 st001799 48.1 µM -1.55669628788492 0.0726200964798275 no 3169 0.0597713052103849 4488 621897
SGTC_1670 st016595 4.04 µM -1.55874034239487 0.0723422608580954 no 3170 0.0595289246245103 4548 597879
SGTC_3289 9119912 71.43 µM -1.55987646577703 0.0721881872360233 no 3171 0.0593945384709475 4520 17014829
SGTC_2090 5301565 104.445 µM -1.55992845054402 0.0721811434239162 no 3172 0.0593883951567959 4534 2056344
SGTC_2654 protoveratrine a 100 µM -1.56035368378006 0.072123545110838 no 3173 0.0593381618036205 4531 5702278 A heart drug and vasodilator.
SGTC_2897 9048598 12.99 µM -1.56438871676872 0.0715787474318142 no 3174 0.0588631544349331 4515 6467404
SGTC_2832 7992762 51.95 µM -1.57290611184711 0.0704391284026489 no 3175 0.057870279849056 4459 2985177
SGTC_2119 5528445 120.635 µM -1.57373662855908 0.0703287567515157 no 3176 0.0577741750268402 4551 791935
SGTC_2222 6885208 172.143 µM -1.57730725572893 0.0698557520503759 no 3177 0.057362421845137 4558 609514
SGTC_1213 1315-0166 115 µM -1.57999352298318 0.0695015161024019 no 3178 0.0570541748910659 4529 768401
SGTC_2304 7443016 91.4 µM -1.58166371771352 0.0692819672463695 no 3179 0.0568631798277544 4476 939854
SGTC_288 1315-0019 35.1 µM -1.58387759206421 0.0689917750683784 no 3180 0.0566107887802223 4569 6811474
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.58496906367212 0.0688490514199054 no 3181 0.0564866816601185 4507 364106
SGTC_2152 5568786 200 µM -1.58500148711434 0.0688448151308149 no 3182 0.0564829981947263 4567 5399883
SGTC_719 2810-4230 27.3 µM -1.59305793060671 0.0677984147428901 no 3183 0.0555735978983268 4557 721079
SGTC_1335 1486-0900 202 µM -1.59723578797147 0.0672606381584015 no 3184 0.0551065790390965 4541 X1335
SGTC_2956 9076196 2.52 µM -1.59782538127855 0.0671850115908559 no 3185 0.0550409221524904 4543 16423868
SGTC_2388 9080168 200 µM -1.59970465540328 0.0669443976311913 no 3186 0.054832059309847 4559 15943073
SGTC_3163 9099914 49.47 µM -1.60024935793445 0.0668747810740544 no 3187 0.0547716382264791 4625 16268368
SGTC_334 1502-1024 68.5 µM -1.6041039830878 0.0663837341494494 no 3188 0.0543455670386417 4552 3296216
SGTC_2689 tacrolimus 100 µM -1.60534997596486 0.0662256036123344 no 3189 0.0542084033236992 4531 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_529 4076-0302 30.3 µM -1.60955904035388 0.0656935826707285 no 3190 0.0537470780833833 4513 5816522
SGTC_1318 1280-3875 124 µM -1.61424603302534 0.0651050577397904 no 3191 0.0532370353719402 4572 373245
SGTC_962 1254-0300 21.5 µM -1.61963840049364 0.064433032818346 no 3192 0.052654987814842 4538 7340576
SGTC_2100 5377183 190 µM -1.62014523334694 0.0643701467871395 no 3193 0.0526005413454373 4574 2844202
SGTC_3184 9108758 49.47 µM -1.62235749510738 0.0640962154205179 no 3194 0.0523634122977265 4600 902885
SGTC_87 0100-0052 35.5 µM -1.62981714065762 0.0631792079328933 no 3195 0.0515700750001504 4574 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3355 9151058 44.0485 µM -1.63622309248928 0.0623999118470602 no 3196 0.0508964525594213 4579 17015728
SGTC_2197 6588183 93.1375 µM -1.63657830784709 0.0623569195539097 no 3197 0.0508593055934885 4580 884136
SGTC_615 k087-0205 167 µM -1.64138386167705 0.0617775630462587 no 3198 0.0503588788771232 4579 9642773
SGTC_1605 st000082 49.1 µM -1.64602022244407 0.0612225954387851 no 3199 0.0498797978176842 4531 1114022
SGTC_3145 9085516 49.47 µM -1.6484044546946 0.0609387260590265 no 3200 0.0496348512557003 4556 25236195
SGTC_412 gemfibrozil 100 µM -1.65075329290462 0.0606600779781437 no 3201 0.0493944804539906 4522 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1554 st069299 38.7 µM -1.65291253014014 0.0604048028198423 no 3202 0.0491743333174183 4522 24207999
SGTC_165 k038-0023 64.381 µM -1.65339650039234 0.0603477010789816 no 3203 0.0491250973205096 4539 46368543
SGTC_1484 3473-2379 286 µM -1.65462423897245 0.0602030345615578 no 3204 0.0490003717824503 4673 671917
SGTC_3331 9141060 1.957 µM -1.65636536418954 0.0599983404974953 no 3205 0.0488239254036609 4522 4906567 YPR165W RHO1
SGTC_698 k064-0052 127 µM -1.65693292291295 0.0599317338036758 no 3206 0.0487665186176698 4649 5088751
SGTC_64 000l-0018 272.079 µM -1.6586170054113 0.0597344366437087 no 3207 0.0485964964306177 4488 6811119
SGTC_984 1492-0255 2.91 µM -1.66363948075757 0.0591490540730548 no 3208 0.0480922485448549 4537 1585198
SGTC_233 rapamycin 362 pM -1.67116467199809 0.0582804056932079 no 3209 0.0473445780781057 4588 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2511 berberine 10.47 µM -1.67258556568568 0.0581175193442479 no 3210 0.0472044552023834 4563 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3320 9137005 35.139 µM -1.68386983194011 0.0568365999224023 no 3211 0.0461034138806331 4607 4908713
SGTC_2073 5212005 126 µM -1.68765301076267 0.0564121689580119 no 3212 0.0457389284157295 4521 691789
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.69006788090056 0.0561425559726715 no 3213 0.0455074844245223 4561 97141
SGTC_1937 st074714 47.2 µM -1.69716740927318 0.0553557970228751 no 3214 0.0448325073942218 4522 17250970
SGTC_1185 1319-0113 81.3 µM -1.70067267979653 0.054970571939701 no 3215 0.044502234008767 4624 4672763
SGTC_1339 1486-1321 22.7 µM -1.70944315460172 0.0540159864043837 no 3216 0.0436844464844762 4645 3469382
SGTC_2062 5245942 200 µM -1.70981165099077 0.0539761680347472 no 3217 0.0436503539148166 4624 1376160
SGTC_1297 1068-0111 14.1 µM -1.71045880954599 0.0539062946946893 no 3218 0.0435905320292052 4594 767057
SGTC_2124 5246320 200 µM -1.71190718105687 0.0537501743461869 no 3219 0.0434568875515947 4580 579342
SGTC_1416 3966-0321 25.3 µM -1.71908105443112 0.0529821732404514 no 3220 0.0427998070064203 4648 582530 YLR208W SEC13
SGTC_209 4077-0173 175.592 µM -1.72791420177047 0.0520485219952296 no 3221 0.0420018038899147 4579 15993494
SGTC_3075 9116269 49.47 µM -1.72820061721196 0.0520184684840211 no 3222 0.0419761315635197 4587 17015205 YNL244C SUI1
SGTC_2512 diallyl trisulfide 49.23 µM -1.7318776206568 0.0516338646859944 no 3223 0.0416476770598256 4634 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2381 9035592 200 µM -1.73926364335543 0.0508681418123516 no 3224 0.0409941996268625 4616 4749657
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.73970335149863 0.0508228431058395 no 3225 0.0409555602740474 4601 641818 YHR062C RPP1
SGTC_177 1327-0068 8.361 µM -1.74207473205325 0.0505790970619391 no 3226 0.0407476841818195 4596 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_966 1300-0360 30.2 µM -1.75554846320896 0.0492118057394051 no 3227 0.0395827693438955 4597 70588
SGTC_3172 9105863 49.47 µM -1.75899151806997 0.0488671878988918 no 3228 0.0392894746204779 4709 2348785
SGTC_1674 st016616 23.6 µM -1.76331482643899 0.0484371988562465 no 3229 0.0389237030296612 4578 625830
SGTC_1178 0988-0033 191 µM -1.7662534898824 0.0481466555350663 no 3230 0.0386766653656054 4659 5392207
SGTC_1076 itraconazole 331 nM -1.77027970718039 0.0477508526194238 no 3231 0.0383402784271392 4622 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1358 1509-0022 2.48 µM -1.7782563604305 0.0469743928655049 no 3232 0.0376808800669442 4641 3258434
SGTC_401 neomycin 50 µM -1.77981181877425 0.0468241683226792 no 3233 0.0375533813788532 4627 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_170 4197-0004 226 µM -1.78317540070847 0.0465006347436915 no 3234 0.0372788777480867 4622 218692
SGTC_2449 5812982 45.77 µM -1.78513143251193 0.0463133161249662 no 3235 0.0371200002873752 4554 776185
SGTC_162 k030-0015 37.8 µM -1.78815169231468 0.0460252725896355 no 3236 0.036875768823575 4658 1809920 YMR134W ERG29
SGTC_25 0118-0223 35.662 µM -1.79068539967468 0.0457847434023896 no 3237 0.0366718969841636 4603 5333628
SGTC_557 1315-0110 16.2 µM -1.79302919732713 0.0455631431707451 no 3238 0.0364841277924475 4603 6833801
SGTC_1710 st031758 61.5 µM -1.7951119735443 0.0453669462824441 no 3239 0.0363179307249913 4658 5394341
SGTC_1459 k035-0031 35.7 µM -1.79684584884104 0.0452041345701506 no 3240 0.0361800476754063 4385 3877128 YMR208W ERG12
SGTC_1195 1502-0147 41.1 µM -1.79815542521381 0.0450814766197199 no 3241 0.0360761905313019 4637 817940
SGTC_2144 5628481 200 µM -1.80303015234948 0.0446272507477517 no 3242 0.0356917397010841 4620 2818399
SGTC_272 doxorubicin 8.13 µM -1.81225731657147 0.0437775622265206 no 3243 0.0349732232360829 4652 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.82003400004763 0.0430716202530349 no 3244 0.0343769136510562 4622 5377381
SGTC_216 k038-0035 28.382 µM -1.83180268173035 0.0420208150278219 no 3245 0.0334904117859222 4588 4444231 YPR107C YTH1
SGTC_545 4218-0007 221 µM -1.83330744591359 0.0418879663626869 no 3246 0.0333784313547503 4638 2840508
SGTC_1702 st027038 51 µM -1.83500828460479 0.0417382168188114 no 3247 0.0332522309735686 4666 5521182
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.83634094507919 0.0416211865596785 no 3248 0.0331536238430897 4685 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1782 st039423 80.636 µM -1.84472324254742 0.0408911595628687 no 3249 0.0325389040277196 4645 2068169
SGTC_1898 st060199 18.6 µM -1.8493304891318 0.0404943523082015 no 3250 0.0322050529009318 4651 688866
SGTC_2868 9035608 32.47 µM -1.85202187292691 0.0402640023122811 no 3251 0.0320113410408861 4627 6462614
SGTC_1062 mesoridazine 14.2 µM -1.86050343273849 0.0395450366300539 no 3252 0.0314071666208047 4701 4078 A neuroleptic.
SGTC_772 k072-0172 35.3 µM -1.86213837106771 0.0394076536591129 no 3253 0.031291794313393 4673 5861980
SGTC_1995 st072814 61.1 µM -1.87641034007665 0.0382248066266746 no 3254 0.0302994779115686 4654 5769371
SGTC_1926 methyl fluorone black 53.6 µM -1.88492114673475 0.0375333280747985 no 3255 0.029720242307312 4308 72721 Reacts with homocysteine.
SGTC_3115 9123671 49.47 µM -1.89528757126719 0.0367049192020307 no 3256 0.0290271569283235 4735 3286988
SGTC_912 3474-0017 2.18 µM -1.89801788112906 0.0364892386750889 no 3257 0.0288468632845651 4649 3360550
SGTC_1829 berberine 14.4 µM -1.90233018172017 0.0361507022931397 no 3258 0.0285640011462205 4611 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2558 carylophyllene oxide 100 µM -1.90269945203291 0.0361218327302319 no 3259 0.0285398867480114 4717 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1849 st056239 19.2 µM -1.90452290605036 0.0359795517043036 no 3260 0.028421058178385 4658 5393181
SGTC_1578 josamycin 24.2 µM -1.91764169392787 0.0349693938045855 no 3261 0.0275782297790831 4659 5282165 A P450 substrate.
SGTC_1640 st009078 66.4 µM -1.92288484267839 0.0345722320468085 no 3262 0.0272472568659161 4644 690618
SGTC_1715 st032160 10.2275 µM -1.92653220789446 0.0342981400196053 no 3263 0.0270189771184201 4582 5289825
SGTC_2699 st077704 54.6 µM -1.93799762088143 0.0334481472818699 no 3264 0.0263117564007828 4660 645852
SGTC_36 0335-0881 14.2 µM -1.94858691273901 0.0326785855187618 no 3265 0.0256723881448138 4595 23828853
SGTC_1070 indatraline 8.81 µM -1.95029768622902 0.032555638204417 no 3266 0.0255703241466672 4704 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1897 st060201 15 µM -1.95219085301744 0.0324200279011731 no 3267 0.0254577748811511 4666 611878
SGTC_2214 7179297 48.276 µM -1.95719765621233 0.0320636280835714 no 3268 0.0251621171403593 4729 769744
SGTC_3112 9123419 49.47 µM -1.9600989641289 0.0318585885651863 no 3269 0.024992112151963 4704 17015854
SGTC_2907 7721985 69.9 µM -1.96047363327477 0.0318321893059501 no 3270 0.0249702284172035 4666 3267881
SGTC_1128 3448-9350 235 µM -1.96281264683809 0.0316677902194838 no 3271 0.0248339738740953 4624 619386
SGTC_2628 lathosterol 100 µM -1.97163391049891 0.0310540824711523 no 3272 0.0243257065849997 4691 6710616
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.97261755807275 0.030986262708783 no 3273 0.0242695755255561 4683 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1725 st036284 20.55 µM -1.97803627601672 0.0306148511269646 no 3274 0.0239623072194228 4656 707914
SGTC_1689 st020265 53.493 µM -1.97876065565847 0.0305654809880181 no 3275 0.0239214800854918 4669 5758320 YPR016C TIF6
SGTC_580 1123-0028 41 µM -1.97954047745899 0.0305124059097283 no 3276 0.0238775935093415 4708 1677248 YPR107C YTH1
SGTC_1594 piperine 70.1 µM -1.98534591612934 0.0301196798092897 no 3277 0.0235529993939293 4663 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1154 4088-0362 150 µM -1.98638561452052 0.0300497906967058 no 3278 0.0234952613600702 4701 6618304
SGTC_1965 Pectolinarigenin 58.4 µM -1.98786089928902 0.0299508520365298 no 3279 0.0234135381027509 4672 5320438 An anti-inflammatory.
SGTC_2228 7354201 200 µM -1.99937913231843 0.0291876445074328 no 3280 0.0227836740131037 4745 753451
SGTC_2433 5607874 27.82 µM -2.00091429003473 0.0290871545670935 no 3281 0.0227008136573688 4655 2252428
SGTC_920 mycophenolic acid 780.421 nM -2.01172987759423 0.0283872942434396 no 3282 0.0221242096556778 4679 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_583 1488-1091 88.9 µM -2.02230993116471 0.0277162893773698 no 3283 0.0215721716475714 4739 4303273
SGTC_2695 st077686 51.995 µM -2.0260742692476 0.0274807592680619 no 3284 0.0213785872107935 4658 2876092
SGTC_2566 crystal violet carbinol 226 nM -2.0313983231322 0.0271504908053411 no 3285 0.0211073022002884 4620 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_677 0929-0063 136 µM -2.03432225670938 0.026970522871118 no 3286 0.0209595572899803 4712 1539583
SGTC_2154 5570129 200 µM -2.03645529757692 0.0268398634094967 no 3287 0.020852328775829 4712 673366
SGTC_3220 9131269 49.47 µM -2.04716296252763 0.026191925339505 no 3288 0.0203210433199786 4704 17722206
SGTC_1136 pergolide 1.05886 µM -2.04755302494038 0.0261685711091911 no 3289 0.0203019080951425 4649 47811 A dopamine receptor agonist.
SGTC_329 k048-0121 21.3 µM -2.05298225872169 0.0258453101722787 no 3290 0.0200371490908631 4702 6832902
SGTC_980 1473-0395 201 µM -2.05533223301167 0.0257064305878572 no 3291 0.0199234630207466 4663 768876
SGTC_1737 st035557 69.7 µM -2.05561466353287 0.0256897815388436 no 3292 0.0199098366286585 4581 5716916
SGTC_1960 st011366 51.8 µM -2.05963504239235 0.0254537606030089 no 3293 0.0197167217867464 4722 3972846
SGTC_999 SEC7.066 22.7 µM -2.06855451097377 0.0249366116336215 no 3294 0.0192939551676097 4688 740511 YDR170C SEC7
SGTC_34 0469-0683 81.75 µM -2.08016040700119 0.0242769206971617 no 3295 0.018755411224342 4689 3690923
SGTC_338 4055-0136 114 µM -2.08454765325345 0.0240313918971139 no 3296 0.0185551901714049 4687 2900563
SGTC_714 4296-0578 26.1 µM -2.13002941179879 0.0216067441623553 no 3297 0.0165845926163915 4738 1589775
SGTC_1481 3346-2004 36 µM -2.13952814565099 0.0211273548039872 no 3298 0.0161964594811141 4758 2770522
SGTC_2762 leflunomide 42.06 µM -2.14114757661031 0.021046528625513 no 3299 0.0161310695109656 4679 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_885 0865-0106 16.8 µM -2.14170551127314 0.0210187426445203 no 3300 0.016108593477649 4696 2793380
SGTC_2593 nobiletin 86.24 µM -2.1799553936139 0.0191864666147315 no 3301 0.0146303840988581 4699 72344 An anti-infammatory.
SGTC_1457 k015-0032 57.3 µM -2.18877597161285 0.0187837582890434 no 3302 0.0143065635001205 4724 4302660
SGTC_2051 5263410 176 µM -2.2019925076249 0.0181938238811843 no 3303 0.0138329188581878 4677 227584
SGTC_3109 9122853 49.47 µM -2.216583284491 0.0175609588218267 no 3304 0.0133257904334827 4739 1234709
SGTC_1802 st050112 57.9 µM -2.2181909996281 0.0174923885688651 no 3305 0.0132709060804028 4738 4662563
SGTC_1992 st073643 23.3 µM -2.22424877443478 0.0172360695816427 no 3306 0.0130658555565832 4731 3161292
SGTC_1720 st037298 9.481 µM -2.23701146693163 0.0167065356901426 no 3307 0.0126427952968122 4699 597396
SGTC_244 nsc-207895 1.295 µM -2.25684362421857 0.0159113196469264 no 3308 0.0120089238796591 4665 42640
SGTC_1741 st038134 10.228 µM -2.26506965763822 0.0155911267950938 no 3309 0.0117542026307729 4718 1272587
SGTC_2191 5911152 200 µM -2.28459068877062 0.0148533385909862 no 3310 0.0111684197108721 4740 2875902
SGTC_1967 st070177 51.4 µM -2.29091895099152 0.0146206998427287 no 3311 0.0109840508517186 4745 5729214
SGTC_1485 3909-9022 254 µM -2.2968287755344 0.0144062816751367 no 3312 0.0108142696702082 4782 714516
SGTC_16 erodoxin 22.806 µM -2.31362471054291 0.0138116179192229 no 3313 0.010344158509763 4768 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3099 9120367 49.47 µM -2.32667177206703 0.013364409170384 no 3314 0.00999137067540151 4757 24824940
SGTC_2040 5100729 123 µM -2.33958095937682 0.0129342896881933 no 3315 0.00965269344456699 4761 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1223 0764-0573 147 µM -2.34248677475373 0.0128391386168241 no 3316 0.00957785643296123 4751 1609797
SGTC_59 0330-0160 1.33 µM -2.39372072780656 0.0112582472999691 no 3317 0.00833922128397608 4708 4293482
SGTC_377 3970-0964 33.1 µM -2.42937342798376 0.0102605754777213 no 3318 0.00756247249219606 4754 16481235
SGTC_678 1218-2179 85.9 µM -2.43015596502595 0.0102395712897181 no 3319 0.00754616336973782 4773 6820081 YOR116C RPO31
SGTC_251 melphalan 456.522 µM -2.46690220920917 0.00929456549503103 no 3320 0.00681437860742112 4771 460612 A DNA alkylator.
SGTC_720 r052-1644 49.9 µM -2.49975559133024 0.00851520684123461 no 3321 0.00621395070343626 4760 1422863 YOR257W CDC31
SGTC_578 3460-0051 92 µM -2.51564353627486 0.00815932068576939 no 3322 0.00594076427252752 4779 2876744
SGTC_1910 st062352 60.4 µM -2.53193699890083 0.00780799051892328 no 3323 0.00567171852147024 4720 2245730
SGTC_1172 0370-0043 85 µM -2.55044457889761 0.0074251248764537 no 3324 0.00537928139240537 4762 376585
SGTC_2804 7954240 19.48 µM -2.55194067737223 0.00739491030872434 no 3325 0.00535623783905373 4738 828705
SGTC_1896 st058441 89 µM -2.55982643616107 0.00723743683383373 no 3326 0.00523622254913856 4772 688759
SGTC_1719 st032227 49.2 µM -2.58582397247266 0.00673902820804475 no 3327 0.00485732646019015 4759 3125804
SGTC_1192 1488-0095 21.4 µM -2.59657794930241 0.00654189162429246 no 3328 0.00470787693751704 4783 915875
SGTC_776 4476-4378 112 µM -2.61014640031402 0.00630044921635138 no 3329 0.00452517408496992 4771 2892008
SGTC_3122 9126309 49.47 µM -2.62126310201516 0.00610854870393693 no 3330 0.00438023119693502 4791 17591206
SGTC_709 3807-1509 243 µM -2.64577556624405 0.00570360108668531 no 3331 0.00407519360366456 4794 1886677 YPL242C IQG1
SGTC_2813 7971799 71.43 µM -2.65110387114255 0.00561879649651506 no 3332 0.00401145817768486 4751 2234054
SGTC_572 0960-0087 17.7 µM -2.6797249832126 0.00518214937830384 no 3333 0.00368413346613186 4765 6796365
SGTC_860 0443-0016 25.1 µM -2.69679373941898 0.00493636392599648 no 3334 0.00350053101940581 4779 5337942
SGTC_371 0195-0006 7.36 µM -2.70310781525108 0.004848108854367 no 3335 0.00343472301396845 4680 3928593
SGTC_1190 1486-1332 13 µM -2.70585159692704 0.00481019798458293 no 3336 0.00340647422386033 4778 4150046
SGTC_2540 epiandrosterone 100 µM -2.73245933145391 0.00445604483784448 no 3337 0.00314317159067327 4781 441302 A steroid.
SGTC_1865 st057639 52.2 µM -2.7519006675469 0.00421219779551097 no 3338 0.00296252449758614 4784 688818
SGTC_785 1270-0111 65.3 µM -2.78206214684361 0.00385746292251581 no 3339 0.00270073478484342 4763 6741994
SGTC_2171 5739187 198.077 µM -2.84840527268124 0.00316972566334373 no 3340 0.00219694658370568 4776 2262761
SGTC_1958 st076513 41.9 µM -2.86475824253381 0.00301813451795502 no 3341 0.00208663859193721 4761 732122 YGL099W LSG1
SGTC_771 0250-0039 27.3 µM -2.90802809904234 0.00264802694496314 no 3342 0.00181857827525087 4783 3005115
SGTC_1006 4099-6547 255 µM -2.94785928603292 0.00234410697861831 no 3343 0.00159991339671736 4793 3146833
SGTC_2317 5986382 200 µM -3.04510056242445 0.00173030201309772 no 3344 0.00116301260773627 4787 877883
SGTC_2026 5148700 152 µM -3.11705378483107 0.00137459961450012 no 3345 0.000913341213431271 4793 79838
SGTC_2855 9016525 58.44 µM -3.15123069724708 0.00123024751460561 no 3346 0.000812920084708586 4772 43811474
SGTC_1728 st035614 33.7865 µM -3.1891377510673 0.00108645972738002 no 3347 0.00071348930688029 4780 15945546
SGTC_2814 7977482 42.97 µM -3.21727392742647 0.000989881523750373 yes 3348 0.000647074866161366 4791 6456762
SGTC_413 propylparaben 100 µM -3.21811606280964 0.000987116268944811 yes 3349 0.000645177964233043 4799 7175 A pharmaceutical preservative.
SGTC_414 piperonyl butoxide 100 µM -3.3319205522445 0.000672386530994181 yes 3350 0.000431244373652918 4800 5794 A potent inhibitor of cytochrome P450.
SGTC_3332 9141069 11.198 µM -3.49194402303445 0.000384146661277285 yes 3351 0.000239759364238553 4798 17332883
SGTC_2850 9015429 58.44 µM -3.69677434178711 0.000181334520671913 yes 3352 0.000109178136274808 4797 6457570
SGTC_2969 9091408 28.7 µM -3.69724791487491 0.00018101200908237 yes 3353 0.00010897473566537 4796 4286311
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -4.06575135259481 4.25563026389856e-05 yes 3354 2.39389805645164e-05 4805 75037 A free radical scavenger.
SGTC_1249 0481-0015 10.2 µM -4.43564499843792 8.77003905791333e-06 yes 3355 4.58985091644974e-06 4801 4227577
SGTC_2134 5324836 1.464 µM -5.10500081668096 3.63825820312236e-07 yes 3356 1.65396543334192e-07 4810 699272