SGTCid condition conc unit BRR2|YER172C.score BRR2|YER172C.strain.pval BRR2|YER172C.strain.significant BRR2|YER172C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_179 1273-0063 6.77 µM 5.68822643166189 5.01392207431846e-12 yes 1 6.41827724291239e-09 1 3108139
SGTC_769 0302-0231 76 µM 5.37373995401045 6.46876465227269e-11 yes 2 3.8560029111842e-08 4 571869 YER009W NTF2
SGTC_359 0081-0058 15.9 µM 4.08615061445864 5.31876243777455e-07 yes 3 2.1929456422738e-05 13 3494159
SGTC_1345 1488-0192 31.4 µM 3.30567133529188 4.05939050151172e-05 yes 4 0.000473745778249951 4 658348
SGTC_1343 1487-0095 224 µM 3.12811676505051 9.67551990281998e-05 yes 5 0.000879651370728712 7 4560101 YGL055W OLE1
SGTC_763 3453-1109 128 µM 3.11350050267363 0.000103726329058946 yes 6 0.000924410975042075 13 1560353
SGTC_1691 st019933 84.6 µM 3.09133712271541 0.000115202655873337 yes 7 0.000996286327028389 5 6176082
SGTC_1828 st055811 49 µM 3.0669363797393 0.000129210736746083 yes 8 0.00108132440614707 3 5877589
SGTC_1047 2043-3044 82 µM 3.05379279564187 0.000137403051825075 yes 9 0.00112984047190408 19 669592
SGTC_1370 2001-0092 44.6 µM 2.91262011592818 0.000261991066935972 yes 10 0.00179205163713841 14 790957
SGTC_2708 st078559 56 µM 2.8951577016149 0.000283228085774456 yes 11 0.00189484045779459 9 17250902
SGTC_1309 pyrazolanthrone 13.4 µM 2.87562402027709 0.00030887832867837 yes 12 0.00201614851269462 26 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.85190701082303 0.000342924663131426 yes 13 0.00217289057455055 28 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_563 tetrahydrosecaminediol 614 µM 2.80138181891291 0.00042739788251898 yes 14 0.00254421374546311 11 334274 A psychoactive constituent of the cannabis plant.
SGTC_2716 st080858 38.6235 µM 2.78792150884871 0.000452955826203186 yes 15 0.00265236973729665 14 5296050
SGTC_1261 0712-0010 12.7 µM 2.74460205262755 0.000545140072637073 yes 16 0.00302921570452808 25 2840123
SGTC_2866 9034245 58.44 µM 2.71327445115954 0.000622301592276097 yes 17 0.00333109519798068 6 6462273
SGTC_182 3448-4371 550.524 µM 2.70943289399252 0.000632428237974591 yes 18 0.00336991688673678 13 3491403
SGTC_1194 1488-0194 225 µM 2.62896645353293 0.000882794580135695 yes 19 0.00428224045441642 15 1391452
SGTC_1553 gossypol 38.6 µM 2.62808650424491 0.000885977438722231 yes 20 0.00429333385301876 9 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2365 9042475 200 µM 2.60494504579702 0.000973564348461877 yes 21 0.0045944498413933 21 6464479
SGTC_384 k007-0144 5.16 µM 2.59259512030152 0.00102349529747371 no 22 0.00476274180801365 48 6824886
SGTC_3013 9080133 71.4286 µM 2.59119454907905 0.00102930374926312 no 23 0.0047821702478888 15 17050193
SGTC_1281 0884-0031 11.8 µM 2.59102883564609 0.00102999299339012 no 24 0.00478447366002555 23 1548255
SGTC_41 0478-0632 82.643 µM 2.51830191393541 0.00137680071918463 no 25 0.00589610961999426 46 3750424
SGTC_2808 7946468 45.46 µM 2.48284629832599 0.00158196284151976 no 26 0.0065168656090566 37 2970879
SGTC_910 3454-3003 490 µM 2.44394756095214 0.001838810344091 no 27 0.00726376897461768 34 820824
SGTC_1134 3477-0009 42.5 µM 2.43241354277291 0.00192194991844385 no 28 0.00749928588659666 55 3973534
SGTC_770 0389-1121 67.2 µM 2.42855253206699 0.0019505347645165 no 29 0.0075796144194796 29 6753108
SGTC_621 3584-0052 32.1 µM 2.40369593215467 0.00214399281993528 no 30 0.00811513345303371 31 2273927
SGTC_1988 st071872 53.4 µM 2.37178163892898 0.00241784263545263 no 31 0.00885127466258584 11 16414116
SGTC_1031 k035-0009 16 µM 2.37113507868057 0.00242370385131031 no 32 0.00886677436088388 22 5180959
SGTC_649 1123-0311 367 µM 2.35108451419078 0.00261196962651425 no 33 0.00935939084484067 44 693629 YIL048W NEO1
SGTC_1787 fluconazole 80 µM 2.30218655704376 0.00312768326707559 no 34 0.0106623268735169 42 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1219 1469-0211 33.1 µM 2.30023308458569 0.00315007072870907 no 35 0.0107175091953713 27 6822282
SGTC_2525 harmine 47.85 µM 2.29808594930068 0.00317484393753666 no 36 0.0107784488956367 26 5280953 A monoamine oxidase inhibitor
SGTC_3017 9080681 49.47 µM 2.29662046124339 0.00319185296925014 no 37 0.0108202151869213 23 16451914
SGTC_1333 1482-0047 286 µM 2.29103542420329 0.00325742936585631 no 38 0.0109806824628925 35 3811116
SGTC_1191 1487-1166 10.6 µM 2.28979096745697 0.00327220515975992 no 39 0.0110167185120281 27 3955771
SGTC_2629 bisabolol 100 µM 2.28531576564106 0.00332583996573376 no 40 0.0111471595782408 49 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1284 0929-0043 16 µM 2.27880784582452 0.00340524750123752 no 41 0.0113392451573479 36 1239883
SGTC_2466 5983409 37.09 µM 2.22479185165489 0.00413293785125602 no 42 0.0130476073332493 41 2879657
SGTC_3322 9139058 2.11 µM 2.21812886684334 0.00423172601506156 no 43 0.01327302354305 44 4908926 YPR165W RHO1
SGTC_790 1575-0012 79.1 µM 2.19799669108384 0.00454316830502529 no 44 0.0139746708693925 37 378741 YLR208W SEC13
SGTC_439 amiodarone 34.4 µM 2.18931231511541 0.00468371867858768 no 45 0.0142870739350015 38 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_588 3970-1144 52.9 µM 2.17892534088427 0.00485690959152792 no 46 0.0146686074551151 14 1888707
SGTC_1759 st043059 70 µM 2.16459145595755 0.00510527989919755 no 47 0.0152094929494469 44 669426
SGTC_1270 0831-1170 17.3 µM 2.15700144382121 0.00524132211800886 no 48 0.0155027759732018 40 6764716
SGTC_2861 9024595 19.48 µM 2.13835082493523 0.00558940452254836 no 49 0.0162441402032597 12 16482810
SGTC_275 trichlorophene 5.69 µM 2.132245477194 0.00570773056428445 no 50 0.0164933358314011 37 62616
SGTC_45 0kpi-0036 14.9 µM 2.11778585737302 0.00599688024130104 no 51 0.0170966038084311 39 2795021
SGTC_1564 D-Arginine 115 µM 2.11322455063161 0.00609074930309118 no 52 0.0172907764703332 66 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2143 5623677 140.463 µM 2.10675854640093 0.00622604664541912 no 53 0.0175692572172503 35 5375313
SGTC_1748 st037455 53.6035 µM 2.10024793182399 0.00636495995178065 no 54 0.0178535184681227 50 580690
SGTC_2252 omeprazole 400 µM 2.07981836762153 0.00681882642428455 no 55 0.0187710978649427 23 4594 A proton pump inhibitor.
SGTC_2876 9059903 25.97 µM 2.05610314286748 0.0073813465052664 no 56 0.019886287690026 41 6916095
SGTC_784 4579-0127 173 µM 2.05464630368624 0.00741719903552374 no 57 0.0199565899220907 40 1948547
SGTC_2764 methyldopa 94.69 µM 2.03713972178944 0.00786018485027431 no 58 0.0208180211588238 37 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_462 ag-879 158 µM 2.03051464350789 0.00803379985468921 no 59 0.0211521271111503 68 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_549 1661-1316 519 µM 2.02553394430041 0.00816653371174869 no 60 0.0214062832960765 62 2857282
SGTC_833 3852-0053 558 µM 2.01483509992299 0.00845818566403439 no 61 0.0219609649888286 55 3123681
SGTC_845 0330-0138 4.51 µM 2.01053769312404 0.00857788281169335 no 62 0.022187155496572 45 9039800
SGTC_1685 st024049 53.0905 µM 2.00684736924814 0.0086818540097989 no 63 0.0223829586530479 49 1941139
SGTC_3177 9107506 49.47 µM 2.00208090937885 0.00881777873847213 no 64 0.0226380151872355 33 8897194
SGTC_270 tamoxifen 5.46 µM 2.00080826318657 0.00885438470892282 no 65 0.0227065282950117 59 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2463 5473429 200 µM 1.99231318829003 0.00910216334527651 no 66 0.0231683527868124 41 5399405
SGTC_2692 st077426 47.7 µM 1.98505846714653 0.00931854916947586 no 67 0.0235689834702938 68 25238571
SGTC_1291 0993-0025 5.79 µM 1.9845282986586 0.00933453748749694 no 68 0.0235984883001123 45 4353356
SGTC_884 0851-0618 334 µM 1.97569694765117 0.00960441648883649 no 69 0.0240945554211698 53 9642473
SGTC_1088 bifonazole 369 nM 1.97059972421221 0.00976326754068146 no 70 0.0243848391058701 38 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2973 9094665 17.96 µM 1.96660536908509 0.00988934781535903 no 71 0.0246143620066731 77 25237061 YIL048W NEO1
SGTC_797 k781-0471 270 µM 1.96367990601977 0.00998258864675516 no 72 0.0247836121492845 60 23738129
SGTC_1117 retinoic acid 1.10837 µM 1.94854214475622 0.0104774204191184 no 73 0.0256750635552959 42 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2384 9036245 200 µM 1.93666303424183 0.0108805691893379 no 74 0.0263932736106283 41 6462766
SGTC_2041 5107442 45.335 µM 1.93299732571333 0.0110076702692236 no 75 0.026618263622329 92 793005
SGTC_2628 lathosterol 100 µM 1.92524256824144 0.0112808137598884 no 76 0.0270995094435603 64 6710616
SGTC_2605 digitonin 300 nM 1.9251834845335 0.0112829172592087 no 77 0.0271032037546225 73 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1630 st005209 31.3 µM 1.92270207514301 0.0113715688059854 no 78 0.0272587380459338 47 3367314
SGTC_491 tetrandrine 80.3 µM 1.91809321230093 0.0115378332749073 no 79 0.0275495964964083 52 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_120 rhodamine 6G 52.259 µM 1.91727572598512 0.0115675434542779 no 80 0.0276014560329484 107 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1221 2958-7315 257 µM 1.90989740995482 0.0118387152707515 no 81 0.0280732118143623 65 4562705
SGTC_2860 9025725 38.96 µM 1.90086940099694 0.0121780064211078 no 82 0.0286595604588988 56 40546248
SGTC_1977 st070720 65.3 µM 1.90051442540703 0.0121915176047426 no 83 0.0286828218658287 32 682188
SGTC_2060 5238662 140 µM 1.89646540081535 0.0123465543323592 no 84 0.0289492654581789 45 790130
SGTC_2693 st077581 40.7 µM 1.89379865419861 0.0124495941050275 no 85 0.0291258701837954 46 25238761
SGTC_2634 4'-methoxyflavone 100 µM 1.88611082580075 0.0127508205692567 no 86 0.029640010887407 51 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_224 benfluorex 43.875 µM 1.87567358466686 0.0131698542085244 no 87 0.0303500576346243 43 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3086 9117350 49.47 µM 1.87158872529858 0.0133370638216232 no 88 0.0306317622165715 20 2679265
SGTC_1106 tegaserod maleate 11.7 µM 1.86751629528947 0.0135055866669972 no 89 0.0309147616939151 62 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_141 0443-0274 32.331 µM 1.8549539244346 0.0140370655731207 no 90 0.0318014032455453 51 1627241
SGTC_1851 st056236 18.9 µM 1.85328989444366 0.0141088006069115 no 91 0.0319204094184773 61 5393171
SGTC_580 1123-0028 41 µM 1.84644863816691 0.0144070506355824 no 92 0.032413545270859 88 1677248 YPR107C YTH1
SGTC_2524 avocatin b 10.57 µM 1.83356681641523 0.014983396525638 no 93 0.0333591608983975 34 6710748
SGTC_1616 st002734 56.1 µM 1.83142213091458 0.0150812516452994 no 94 0.0335187802808502 64 4026101
SGTC_973 1325-0077 65.9 µM 1.82866309148111 0.0152079450693916 no 95 0.0337250474155815 50 2835149
SGTC_1379 2144-0755 36.5 µM 1.82794820349523 0.0152409210517452 no 96 0.0337786628302418 57 5392327
SGTC_1380 2291-0730 164 µM 1.82240450521519 0.0154987289635976 no 97 0.0341968157516803 59 2999191
SGTC_791 1348-1292 225 µM 1.82131190750551 0.0155499790591341 no 98 0.0342797287031405 49 5437054
SGTC_1891 st059073 26.2 µM 1.81904275396458 0.0156568823016948 no 99 0.0344524538106597 64 688754
SGTC_3287 9117173 37.0625 µM 1.81745665992859 0.0157319794576451 no 100 0.0345736093781845 22 2789709
SGTC_1996 st072960 66.8 µM 1.80178215846334 0.0164908857863181 no 101 0.0357898429307481 65 1719405
SGTC_2616 abietic acid 100 µM 1.78982445004187 0.0170907140740968 no 102 0.036741068640703 69 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1200 1643-0193 18.4 µM 1.77988918008126 0.0176031815697427 no 103 0.0375470493904324 74 5403974
SGTC_1793 st048256 72.231 µM 1.77732525746069 0.0177375398435277 no 104 0.037757370168201 56 672022
SGTC_988 1497-1057 103 µM 1.76738287007619 0.0182668606239496 no 105 0.0385820648809589 65 3533044
SGTC_2014 4013930 200 µM 1.76015578391356 0.0186600175377511 no 106 0.0391906983045459 63 64556
SGTC_2695 st077686 51.995 µM 1.75782200996347 0.0187885047205013 no 107 0.0393888995547226 64 2876092
SGTC_190 3970-0790 3.722 µM 1.75729879980876 0.0188174134193931 no 108 0.039433446135958 59 2832352
SGTC_2879 9041815 71.43 µM 1.75621683029535 0.018877315071104 no 109 0.0395256960029446 33 4942971
SGTC_2204 7233102 200 µM 1.74767429626234 0.0193559810004222 no 110 0.0402602210518347 62 2172480
SGTC_2891 9063876 19.48 µM 1.74464472252219 0.0195281971462755 no 111 0.0405233654550329 42 6472478
SGTC_1169 aniline yellow 25.8 µM 1.73455569520672 0.0201111206989208 no 112 0.0414097663492132 61 6051 A DNA damaging agent.
SGTC_2523 spermine 47.74 µM 1.72889071400692 0.0204448543459962 no 113 0.0419143281673293 50 1103 A DNA binding polyamine.
SGTC_1096 rimcazole 32.2 µM 1.71962304454196 0.0210009446761808 no 114 0.0427504922422992 50 18528119 A dopamine reuptake inhibitor.
SGTC_3297 9117502 71.43 µM 1.71495721399064 0.0212857201239976 no 115 0.0431765358374371 38 7453720
SGTC_1799 st045822 46.1415 µM 1.70630663871272 0.0218223446667533 no 116 0.0439755013511191 78 3674992
SGTC_3233 9132340 49.47 µM 1.70173098899818 0.0221107785855728 no 117 0.044402904217847 99 17682950
SGTC_1216 1165-0504 9.65 µM 1.6910157208398 0.0227988453869422 no 118 0.0454169000806077 76 6304004
SGTC_1499 4480-0877 67.3 µM 1.6850172097892 0.0231918487295997 no 119 0.0459926255924104 60 2861909
SGTC_2804 7954240 19.48 µM 1.68442574148657 0.0232309069191502 no 120 0.0460497097348343 94 828705
SGTC_65 0798-0905 34.986 µM 1.68017133036829 0.0235134858605813 no 121 0.0464619928552708 93 3602145
SGTC_2199 6590217 200 µM 1.67351209330532 0.0239615962104083 no 122 0.0471132639300675 73 703109
SGTC_2363 9053361 176 µM 1.67135798128531 0.0241080772294089 no 123 0.0473254951200317 83 6469797 YMR079W SEC14
SGTC_39 0986-0283 58.349 µM 1.6633243041521 0.0246610233598668 no 124 0.0481237681142896 75 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_645 0845-0943 5.41 µM 1.66315848842168 0.0246725473679421 no 125 0.0481403573264087 71 1885106
SGTC_2520 obtusaquinone 4.71 µM 1.65340835805582 0.0253581581666633 no 126 0.0491238914930299 88 5967872
SGTC_2048 5246248 200 µM 1.64683303637723 0.0258294763296283 no 127 0.0497961844498424 72 677046
SGTC_1188 1403-0014 4.57 µM 1.64440541385933 0.0260053308439184 no 128 0.0500462437871388 85 9614867
SGTC_2870 9038528 12.99 µM 1.63861578915802 0.026428771031631 no 129 0.0506466509657749 77 6463316
SGTC_1834 st055981 52.8 µM 1.63609477286497 0.0266149451172644 no 130 0.0509098770092416 85 471719 YDL150W RPC53
SGTC_2625 euphol 100 µM 1.63546554291704 0.0266615834729641 no 131 0.050975746139514 97 6708538 A triterpene alcohol.
SGTC_785 1270-0111 65.3 µM 1.63490439761424 0.0267032329774249 no 132 0.0510345452321851 81 6741994
SGTC_933 2914-0560 114 µM 1.63221711821345 0.0269034430183276 no 133 0.0513168779369319 80 463887
SGTC_2640 pentamidine 10.38 µM 1.63172362804669 0.0269403453109389 no 134 0.0513688601065314 97 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1416 3966-0321 25.3 µM 1.63152901162983 0.0269549099835511 no 135 0.0513893716900011 85 582530 YLR208W SEC13
SGTC_793 0488-0545 106 µM 1.62014868899354 0.0278180895501088 no 136 0.0526001702763563 88 292548
SGTC_936 3005-4620 401 µM 1.61631197478734 0.0281142398854042 no 137 0.0530134395438386 85 777207
SGTC_2177 5811945 192 µM 1.60428727896438 0.0290594618047542 no 138 0.0543253719120626 79 5343475
SGTC_590 k048-0076 22.4 µM 1.60235827337323 0.0292135250191421 no 139 0.0545382031750894 89 6832814
SGTC_188 3229-0966 278.469 µM 1.59488288965622 0.0298169815813794 no 140 0.0553692132655167 136 5722370
SGTC_1911 st060208 74.3 µM 1.59303054532932 0.0299681018470114 no 141 0.0555766694167584 92 688783
SGTC_1654 st012436 41.8 µM 1.59287029091231 0.0299812057228507 no 142 0.0555946461551362 50 4323132
SGTC_2129 girgensonine 121.053 µM 1.59027482359704 0.0301940975113633 no 143 0.0558864355107192 116 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_478 N-arachidonylglycine 10 µM 1.58912434144475 0.0302888652096544 no 144 0.0560161616446213 34 5283389
SGTC_774 k060-0086 136 µM 1.58079784597251 0.030982108939706 no 145 0.0569621336118146 80 5911235
SGTC_1997 st073024 93.8 µM 1.58072465467688 0.0309882604009477 no 146 0.0569705042899718 76 686268
SGTC_1971 st069429 63.5 µM 1.57984707319124 0.0310620966645618 no 147 0.0570709462070722 55 1246522 YGL099W LSG1
SGTC_7 0192-1582 4.227 µM 1.57259722166462 0.0316776557811512 no 148 0.0579060557098782 119 252616
SGTC_1054 3429-0080 167 µM 1.571350029189 0.0317845599593035 no 149 0.0580506831861416 83 1162877
SGTC_3047 9092122 49.47 µM 1.56953834552508 0.0319403807666439 no 150 0.0582612759179915 82 17173831
SGTC_1184 1269-1718 139 µM 1.5650303571318 0.0323308471599259 no 151 0.0587878957366516 89 5403821
SGTC_1382 3002-2117 298 µM 1.56418155093258 0.0324048067072236 no 152 0.0588874692805049 91 1497314
SGTC_561 1550-0330 72.9 µM 1.56083277318867 0.0326979608148561 no 153 0.0592816062669707 86 6812934
SGTC_503 tyrphostin 8 294 µM 1.560293624235 0.0327453620119493 no 154 0.0593452546945312 97 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1620 st003704 16.5 µM 1.55872447444486 0.0328836418882584 no 155 0.0595308032482555 101 2834414
SGTC_1808 st050063 61.5 µM 1.55679591017039 0.0330542537879206 no 156 0.0597594742702148 83 4011993
SGTC_2770 toltrazuril 17.5 µM 1.55625245372207 0.0331024625861369 no 157 0.0598240363534262 74 68591 Kills coccidiodes.
SGTC_939 1165-0479 45.3 µM 1.54914243043569 0.0337385301872982 no 158 0.0606737424858962 85 1377347
SGTC_683 panaxydol 45 µM 1.54910201314268 0.0337421744910998 no 159 0.0606785995267565 61 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1489 4065-0444 182 µM 1.54261394761918 0.0343313965948352 no 160 0.0614622359378317 79 2877968
SGTC_2447 5741742 33.78 µM 1.54155627078753 0.0344282478038778 no 161 0.0615907294485283 105 1776504
SGTC_1547 harmine 94.2 µM 1.5407230485881 0.0345047037509691 no 162 0.0616921023826702 104 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3174 9107204 49.47 µM 1.5397275928935 0.0345962289553195 no 163 0.061813383983465 70 3938802
SGTC_2863 9028737 58.44 µM 1.53224785981245 0.0352903346206669 no 164 0.062730641147527 71 6460917
SGTC_1059 3448-6867 171 µM 1.5264075868131 0.0358402077475858 no 165 0.0634541946899762 109 3934407
SGTC_194 1486-1323 56.904 µM 1.52312253800698 0.0361525737095628 no 166 0.0638640255765513 113 5178754
SGTC_2707 st078556 66.6 µM 1.52199113192959 0.0362606706223759 no 167 0.0640056513716874 74 17250899
SGTC_2161 5662504 8.5105 µM 1.51331937594697 0.0370980024564284 no 168 0.0650992766502948 93 2859334
SGTC_1507 4075-3230 155 µM 1.50711442970173 0.0377067894928405 no 169 0.0658906643679671 80 659771
SGTC_2027 5150920 200 µM 1.5061311026242 0.0378040112850131 no 170 0.066016760836465 77 786715
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.50593693377134 0.0378232329739602 no 171 0.0660416820749933 104 616764
SGTC_464 bw-b 70c 158 µM 1.50412017211271 0.0380034694860281 no 172 0.0662752135944521 106 5353454
SGTC_1315 1237-0019 3.69 µM 1.50334784719124 0.0380803019177888 no 173 0.0663746838695157 87 825140
SGTC_652 0437-0092 114 µM 1.5024765736976 0.0381671299962014 no 174 0.0664870367770568 91 3091274
SGTC_1550 gossypolone 36.6 µM 1.50055076989532 0.0383596217995582 no 175 0.0667358963383698 97 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_846 0335-0850 148 µM 1.48394874546074 0.0400520837518394 no 176 0.0689112592964707 88 6819598
SGTC_1698 5-fluorocytosine 1.055 µM 1.4826048846851 0.0401916949131549 no 177 0.0690897092925919 100 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1344 1488-0097 29.1 µM 1.48092484736975 0.0403667865705381 no 178 0.0693133004808454 93 747966
SGTC_1635 st007035 42.4 µM 1.47783018627512 0.0406909298516767 no 179 0.0697266182444948 111 3716403
SGTC_1222 0366-0074 1.18 µM 1.4764135525002 0.0408400151330002 no 180 0.0699164533467361 112 286520
SGTC_1359 1582-0056 520 nM 1.47553355531239 0.0409328481899764 no 181 0.0700345769132844 92 3661189
SGTC_2639 lactacystin 53 µM 1.46720864272735 0.0418195584350085 no 182 0.0711596532753254 91 3870 A proteasome inhibitor.
SGTC_2255 7941087 197.44 µM 1.46709993733999 0.0418312390271049 no 183 0.0711744355967224 106 935561
SGTC_2899 9053889 58.44 µM 1.466786550985 0.0418649277493786 no 184 0.0712170646925611 86 6470052
SGTC_662 k832-1615 104 µM 1.46437836883158 0.0421245385563424 no 185 0.071545297527596 94 5878478
SGTC_64 000l-0018 272.079 µM 1.4618845447625 0.0423947535193474 no 186 0.0718864254392885 142 6811119
SGTC_1617 st002906 78 µM 1.45924934706361 0.0426818086157294 no 187 0.0722482456305321 100 5150859
SGTC_2902 5787006 60.46 µM 1.45826590001591 0.0427893384327502 no 188 0.0723836327742844 106 591003
SGTC_393 acivicin 6.25 µM 1.45002429769816 0.0436991035862128 no 189 0.0735258718275103 114 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_862 0452-0056 10.2 µM 1.4478079160028 0.0439464080646371 no 190 0.0738353891400547 75 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1351 1496-0003 46.5 µM 1.44515352090943 0.0442440702487041 no 191 0.0742073842184192 94 3891978
SGTC_2241 6772625 37.8075 µM 1.42958221505403 0.0460231012877842 no 192 0.0764184814887009 109 2285411
SGTC_3346 9158254 43.5805 µM 1.42868310569311 0.0461275550701691 no 193 0.0765476678593948 121 17639500
SGTC_3157 9099274 49.47 µM 1.42581573500224 0.0464619434925242 no 194 0.0769607688619806 96 17217662
SGTC_1192 1488-0095 21.4 µM 1.4187439080474 0.0472949696041926 no 195 0.0779868455707804 93 915875
SGTC_1408 3909-7976 48.8 µM 1.4178115756466 0.0474056812774623 no 196 0.0781228918384375 97 24152374
SGTC_1305 1181-0477 144 µM 1.41673263112685 0.0475340618033514 no 197 0.078280556432447 115 6252086
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.41430976126645 0.0478233671338587 no 198 0.0786354860797125 117 390807
SGTC_587 k089-0003 57 µM 1.41428227471773 0.0478266572634777 no 199 0.0786395196084141 77 9659696
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.4027248516813 0.0492262138545372 no 200 0.0803494518014123 109 756377
SGTC_466 geldanamycin 89.2 µM 1.39987391766764 0.0495764314891623 no 201 0.0807755388880316 72 5288382 HSP90 inhibitor.
SGTC_2420 aureobasidin a 50 nM 1.39655874557453 0.0499861749396005 no 202 0.0812731516876729 94 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_655 k060-0012 42 µM 1.39581628825188 0.0500783091305553 no 203 0.0813849120647041 124 5994525
SGTC_1350 1495-0454 146 µM 1.394654026555 0.0502228101785566 no 204 0.0815600973299294 106 1069057
SGTC_2667 digitoxin 100 µM 1.39383977783227 0.0503242414918825 no 205 0.0816829966096966 70 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2341 7987486 176.74 µM 1.39160857394888 0.0506030202685006 no 206 0.0820204805495168 107 1258686
SGTC_3091 9116372 49.47 µM 1.39023353117763 0.0507754373518839 no 207 0.0822289872065983 97 17169793
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.38634865733021 0.0512650916885115 no 208 0.0828202329611578 119 688662
SGTC_255 tunicamycin 200.472 nM 1.38428691364507 0.0515264781903017 no 209 0.0831353097234739 116 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1231 0242-0792 125 µM 1.38112992056742 0.0519287722435455 no 210 0.0836195086647543 106 3707635
SGTC_142 0335-0849 62.6745 µM 1.3807496763197 0.0519773945253636 no 211 0.0836779707198064 126 3889043 YPR107C YTH1
SGTC_1306 1185-0270 9.02 µM 1.37518496390949 0.052693106968261 no 212 0.0845370543225189 118 1548076
SGTC_3291 9121177 71.43 µM 1.37451024400605 0.0527804159354632 no 213 0.084641666102385 92 17015612
SGTC_3327 9140648 26.9345 µM 1.37330596774791 0.0529365348663297 no 214 0.0848286240716995 158 8029710
SGTC_133 0724-0033 378.92 µM 1.3726844370639 0.0530172514991187 no 215 0.0849252347086731 120 280309
SGTC_480 am 92016 50 µM 1.37232680162298 0.0530637409376594 no 216 0.0849808628815889 146 2129 K+ channel blocker.
SGTC_3347 9188721 44.724 µM 1.37101980943695 0.0532339133251664 no 217 0.0851843904436953 125 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2002 4023503 131 µM 1.36629874445924 0.053852209344641 no 218 0.0859226074689713 131 4736863 YCR052W RSC6
SGTC_967 1306-0166 352 µM 1.36523088634291 0.0539928472988638 no 219 0.0860902468118542 129 4437607
SGTC_1679 SEC14.276 6.7 µM 1.36262994786524 0.0543366100128308 no 220 0.086499582768912 148 1005053 YMR079W SEC14
SGTC_2421 5690543 90.72 µM 1.36113564352351 0.0545348920975018 no 221 0.0867354137168357 128 3397993
SGTC_2398 5228213 48.84 µM 1.36100364761267 0.0545524343556217 no 222 0.0867562683705072 139 80771 YMR134W ERG29
SGTC_865 0488-0499 301 µM 1.35959193249619 0.0547403305164361 no 223 0.0869795462601194 104 9634651
SGTC_1183 1254-0324 198 µM 1.34942206635927 0.0561090765040606 no 224 0.0886007185211393 94 5799357
SGTC_25 0118-0223 35.662 µM 1.34288547604282 0.0570029796464052 no 225 0.0896545300256839 107 5333628
SGTC_18 0111-0177 500 nM 1.3410323021221 0.0572584376343676 no 226 0.0899549825739595 127 721752
SGTC_3168 9103419 49.47 µM 1.33962144690049 0.0574535258457857 no 227 0.0901842237929589 88 16649256
SGTC_601 0986-0029 62.9 µM 1.33622140586746 0.0579258204135788 no 228 0.0907384582222562 123 24747981
SGTC_112 phenothiazine 287.218 µM 1.33445463634589 0.0581724417413349 no 229 0.0910274521805324 109 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_859 0439-0102 54.6 µM 1.33331125921054 0.0583324836285322 no 230 0.0912148401576742 135 610143
SGTC_798 1287-0182 476 µM 1.33289714743857 0.0583905333176732 no 231 0.0912827794116377 114 1649755
SGTC_490 phenamil 164 µM 1.32724642060924 0.0591871866373848 no 232 0.0922135906199308 116 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_596 1155-0152 116 µM 1.32584622677424 0.0593859012586415 no 233 0.0924453187691489 129 280313
SGTC_2262 9014885 67.46 µM 1.32278034487568 0.0598228355134525 no 234 0.0929542177146589 98 6457424
SGTC_3058 9093861 49.47 µM 1.31766522396524 0.0605574181229938 no 235 0.0938078704628448 132 17217477
SGTC_2156 5649887 115 µM 1.31577711177799 0.0608303462796622 no 236 0.0941244318012329 133 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1656 st012921 11 µM 1.31563918030437 0.0608503220253847 no 237 0.0941475882776082 113 6732821
SGTC_3342 9147791 14.508 µM 1.3142686822884 0.0610490813910867 no 238 0.0943779012356604 109 1838168
SGTC_1340 1486-1359 257 µM 1.31204614571537 0.0613724877728546 no 239 0.0947522825525822 133 4309068
SGTC_1250 0485-0349 40.2 µM 1.31125594014253 0.0614877943723758 no 240 0.0948856543085547 122 6842794 YDL195W SEC31
SGTC_676 falcarinol 140 µM 1.30945222355294 0.0617516261166224 no 241 0.095190605654153 129 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1729 st035615 45.989 µM 1.30845742988242 0.0618975134083032 no 242 0.0953591022381153 124 17385451
SGTC_2254 7938975 95.19 µM 1.30586901827327 0.0622783666383292 no 243 0.0957985520450516 111 2969277
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.30451542703049 0.0624782575947829 no 244 0.0960289515247853 122 3256 An antibiotic and ribosome inhibitor.
SGTC_3266 9136860 49.47 µM 1.30151971596175 0.0629224261788225 no 245 0.0965403101900221 138 4871271 YPR165W RHO1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.29517375112386 0.0638714525862979 no 246 0.0976301488309599 127 551469
SGTC_222 nsc-310342 10.666 µM 1.29441822191463 0.0639851781541498 no 247 0.097760499934017 106 432556
SGTC_3018 9082602 49.47 µM 1.29333480613059 0.064148533351315 no 248 0.09794764374708 137 17332089
SGTC_3319 9138450 16.7555 µM 1.29136223724656 0.0644467854793228 no 249 0.0982890493422073 117 2029690
SGTC_2711 st079103 59.1 µM 1.29076318248316 0.0645375754324055 no 250 0.0983929040658993 114 54693780
SGTC_2078 5212016 200 µM 1.28758533473911 0.0650208577195004 no 251 0.0989451735082551 119 1899708
SGTC_3299 9121982 43.1275 µM 1.28411993153869 0.0655510676679456 no 252 0.0995499975437377 116 17594604 YPL160W CDC60
SGTC_608 k048-0125 159 µM 1.28405852284878 0.0655604933969896 no 253 0.0995607396399698 126 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2046 4110841 106 µM 1.28147439851493 0.065958088658151 no 254 0.100013543354637 148 44119630 YMR134W ERG29
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.28013122480306 0.0661654870143129 no 255 0.100249494347964 132 5282309
SGTC_913 3487-1245 167 µM 1.27459862050667 0.06702510135128 no 256 0.101225673007958 138 4016153
SGTC_3105 9121040 49.47 µM 1.27359311186453 0.0671822531532271 no 257 0.101403827331165 97 41448907
SGTC_1079 idarubicin 2.36 µM 1.27292417413188 0.0672869597173144 no 258 0.10152247504006 144 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_821 1114-0266 29.2 µM 1.27198645409961 0.0674339501879067 no 259 0.101688966107282 125 3123235
SGTC_2767 sibutramine 71.45 µM 1.27105890207561 0.0675795908212986 no 260 0.101853847339823 107 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_996 3970-0799 1.8 µM 1.26586855931048 0.0683990476030179 no 261 0.102780072213865 156 6615648 YGL040C HEM2
SGTC_1746 st038117 42 µM 1.26294873702315 0.0688633899733077 no 262 0.103303801592333 134 2898218
SGTC_273 hydroxyurea 18.1 mM 1.2623008983035 0.0689667451041104 no 263 0.103420266794907 154 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3260 9137109 49.47 µM 1.25970419121251 0.0693822199804056 no 264 0.103888046440132 116 17478346
SGTC_2220 6782180 200 µM 1.25831773119452 0.0696048425760371 no 265 0.104138435573562 95 833803
SGTC_2130 NSC 7 2.4545 µM 1.25359776495478 0.0703668476290592 no 266 0.104994122009845 132 21448
SGTC_3096 9117468 49.47 µM 1.25268031739034 0.0705157048142047 no 267 0.105161035922489 111 41316311
SGTC_1020 4335-0961 93.3 µM 1.25026366360083 0.0709089689396164 no 268 0.10560162368693 149 669075
SGTC_2439 5492030 7.2 µM 1.23894890015831 0.0727726739106028 no 269 0.107682211319403 141 5722370
SGTC_410 α-linolenic acid 100 µM 1.23848961861822 0.0728491088477809 no 270 0.107767284528459 140 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1855 st056195 39.6 µM 1.23794453310365 0.0729399032656813 no 271 0.107868314113965 123 4028379
SGTC_2518 prenyletin 46.28 µM 1.23751829472321 0.0730109617492373 no 272 0.107947363335241 95 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_943 3253-1379 105 µM 1.23304620664734 0.0737597038857317 no 273 0.108779262714593 151 668464
SGTC_937 3122-0005 46.7 µM 1.23302190556972 0.0737637884814389 no 274 0.108783795767624 134 759535
SGTC_2696 st077691 74.316 µM 1.23189397626945 0.0739535644197873 no 275 0.108994345937045 142 757133
SGTC_2898 9056270 58.44 µM 1.23186996714614 0.0739576080450799 no 276 0.108998830893411 85 19154699
SGTC_612 0302-0167 22.4 µM 1.22753200165376 0.074690986132329 no 277 0.109811350747316 147 235821
SGTC_987 1497-1013 404 µM 1.22045385844863 0.075899516660429 no 278 0.111146435499259 137 1676435
SGTC_903 1134-0042 114 µM 1.22034956640623 0.0759174342724531 no 279 0.111166193655118 135 701009
SGTC_394 menadione 8.33 µM 1.21841646427927 0.076250129081656 no 280 0.111532875800814 152 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3226 9131256 49.47 µM 1.2161423542474 0.0766429318594576 no 281 0.11196534929984 117 17178073
SGTC_1037 k284-1091 78.7 µM 1.21576218385736 0.0767087478519789 no 282 0.112037764125767 137 3334711
SGTC_2814 7977482 42.97 µM 1.21389789643338 0.0770321199633792 no 283 0.112393358151601 153 6456762
SGTC_1073 triclabendazole 3.09 µM 1.21019464715641 0.0776775428859855 no 284 0.113102105808133 143 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2125 5246583 200 µM 1.2098114330768 0.0777445652674254 no 285 0.113175629050484 157 835267
SGTC_802 4112-3352 742 µM 1.20592587601489 0.0784266122620957 no 286 0.113923036177378 130 704594
SGTC_2076 5212012 200 µM 1.20524678008565 0.0785462809324447 no 287 0.114054024041167 128 604802
SGTC_487 nimodipine 119 µM 1.20463403600093 0.0786543759789055 no 288 0.114172305632529 106 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2663 amphotericin b 100 µM 1.20357136768055 0.0788421100446046 no 289 0.114377645836891 157 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2201 6605497 169.863 µM 1.20267187290069 0.0790012825248352 no 290 0.114551661256769 145 670741
SGTC_893 0958-0369 48.9 µM 1.2006470707746 0.0793604771965028 no 291 0.114944066880322 145 6819948
SGTC_1371 2421-0008 32.7 µM 1.19755494865151 0.0799113951280103 no 292 0.115545161843625 168 2827552
SGTC_1381 2324-0066 62.1 µM 1.19672917664112 0.0800590096407445 no 293 0.115706065477588 151 10885928
SGTC_3339 9145883 14.936 µM 1.1956025527368 0.0802607366260088 no 294 0.115925847411655 127 2030670
SGTC_2926 9010726 65.15 µM 1.19265373973451 0.08079055298575 no 295 0.116502504969215 133 2994293
SGTC_1436 4092-1007 8.32 µM 1.18708569816636 0.081798163319737 no 296 0.117596909511568 120 2881121
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.18562436049763 0.0820641742410501 no 297 0.117885338778882 160 279621
SGTC_2175 5807670 165.306 µM 1.18317536469091 0.0825114315575393 no 298 0.118369827133375 107 241186
SGTC_1736 st036774 51 µM 1.18110178148871 0.0828915602663567 no 299 0.118781146162654 157 1272247
SGTC_2549 cedrol 20.94 µM 1.17758225017315 0.0835397733413938 no 300 0.119481594760682 159 6708665 A sedative which affects the nervous system.
SGTC_2107 5363541 170.161 µM 1.17635898523909 0.0837659591151084 no 301 0.119725727065683 145 244052
SGTC_2766 oltipraz 83.91 µM 1.17501789585317 0.084014459295295 no 302 0.119993778097081 155 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_551 k048-0028 34.9 µM 1.17269891291977 0.084445465927652 no 303 0.120458283761329 168 6836383
SGTC_1650 st011916 45.8 µM 1.17260521781643 0.0844629149215507 no 304 0.120477078011155 149 242528
SGTC_1735 st034310 56.75 µM 1.17233334089791 0.0845135623219948 no 305 0.120531625344192 156 871153
SGTC_634 1611-4317 11.2 µM 1.1689469220515 0.0851463219385051 no 306 0.121212508517386 157 2843522
SGTC_371 0195-0006 7.36 µM 1.16491668871748 0.0859039984708864 no 307 0.122026358738009 138 3928593
SGTC_686 1319-0111 510 µM 1.16467150328856 0.0859502551849375 no 308 0.122075994103901 152 4562600
SGTC_2431 5490079 200 µM 1.16338224930512 0.0861937927288269 no 309 0.12233722409981 174 5722345
SGTC_759 3486-0358 89.3 µM 1.16251105545157 0.0863586515360876 no 310 0.122513968308066 158 875103
SGTC_1422 4031-0024 15.5 µM 1.16151854670079 0.0865467543489509 no 311 0.122715542620912 150 782427
SGTC_2935 9038016 29.96 µM 1.15809131066967 0.0871986479425494 no 312 0.123413387814794 150 6463195
SGTC_228 caffeine 993.056 µM 1.15481640200627 0.0878249863888104 no 313 0.12408280945451 113 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2272 7805186 180 µM 1.14915808319949 0.0889150587741291 no 314 0.125245400782433 159 2956062 YPR165W RHO1
SGTC_2659 sanguinarine 24.21 µM 1.1489174732705 0.0889616344300863 no 315 0.125295005930995 144 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2791 5663188 71.43 µM 1.1485307316134 0.0890365353387136 no 316 0.125374766946247 178 54690634
SGTC_811 0416-0114 265 µM 1.14836973692915 0.0890677292838173 no 317 0.125407980692839 139 6612453
SGTC_2084 5306078 60.6385 µM 1.1469248692201 0.0893480475516272 no 318 0.12570633668371 158 679340
SGTC_1402 3909-7673 35.9 µM 1.1465158929178 0.0894275119487079 no 319 0.125790877535154 146 5328014
SGTC_2 0422-0095 29 µM 1.14644710276384 0.0894408830893693 no 320 0.125805101272003 144 6790840
SGTC_189 3970-0742 2.116 µM 1.14513137290185 0.0896969154197245 no 321 0.126077370618107 146 2891807
SGTC_2783 7738165 71.43 µM 1.14076921190436 0.0905496610506264 no 322 0.126982987980395 154 17201110
SGTC_2839 9003951 25.97 µM 1.1402658796719 0.0906484419260296 no 323 0.127087774149377 131 2990634
SGTC_3309 9129340 25.759 µM 1.14021503435994 0.0906584249591717 no 324 0.127098362720692 145 17158987
SGTC_3300 9124615 50.48 µM 1.1400091842391 0.0906988501728921 no 325 0.127141237424264 148 24824903
SGTC_831 k061-1017 217 µM 1.13639391217738 0.0914110059620624 no 326 0.127895871252913 173 1240153
SGTC_3076 9116187 49.47 µM 1.13473756452812 0.0917386633343759 no 327 0.12824264653665 132 27241210
SGTC_2717 st081029 62.2815 µM 1.13028500186788 0.0926237777230509 no 328 0.129178076132947 144 5292846
SGTC_1004 4084-0029 199 µM 1.13025995662329 0.0926287742107586 no 329 0.12918335117948 132 716894 YLR208W SEC13
SGTC_2346 9031566 143.75 µM 1.12926344810552 0.0928277379344741 no 330 0.12939335766496 142 4771086
SGTC_1338 1486-1223 76 µM 1.12481051187425 0.0937206768095649 no 331 0.130334669524641 155 3444526
SGTC_2380 9035439 200 µM 1.12042110568239 0.0946070668156908 no 332 0.131267177572394 146 6462575
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.12003691271428 0.0946849432862957 no 333 0.13134901624477 154 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2196 6573537 42.6665 µM 1.12002431468351 0.0946874977251724 no 334 0.131351700404403 167 2903087
SGTC_1135 dihydrocapsaicin 536.708 nM 1.11988988300095 0.0947147589192561 no 335 0.131380345024606 166 107982 A Capsaicinoid.
SGTC_1895 st058434 18.3 µM 1.11970302234829 0.0947526617112962 no 336 0.131420168341229 177 5393175
SGTC_3073 9114972 49.47 µM 1.11500536014816 0.0957092110396736 no 337 0.132424062385057 131 41905075
SGTC_1035 k081-0041 55.2 µM 1.11064841474811 0.0966027157910322 no 338 0.133359857266894 170 731709
SGTC_2886 9058944 51.95 µM 1.11055301626606 0.0966223480458738 no 339 0.133380397943793 101 4949929
SGTC_576 1073-0113 22.7 µM 1.11029779557272 0.0966748848587508 no 340 0.1334353613604 194 5439563
SGTC_2127 5253358 187.912 µM 1.10960474586577 0.096817653984139 no 341 0.133584692653827 142 20612
SGTC_1209 2323-2347 50.3 µM 1.10854555037414 0.0970361486339658 no 342 0.133813139271931 157 5412760
SGTC_1491 4138-0063 26.5 µM 1.10816522473284 0.0971146918214398 no 343 0.133895233152072 151 23883227
SGTC_945 3381-0768 11.3 µM 1.1064596347494 0.0974674966460445 no 344 0.134263813027667 161 1126236 YIL048W NEO1
SGTC_2960 9079389 5.97 µM 1.10447683007501 0.0978788245281002 no 345 0.134693174484265 132 16457355
SGTC_1081 sertraline 6 µM 1.10073396661546 0.0986587371825946 no 346 0.135506229265487 171 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2435 5706476 10.6 µM 1.09841098977099 0.0991450655097117 no 347 0.136012532851217 152 5725375
SGTC_1619 st003326 88.7 µM 1.09828311475442 0.0991718876886685 no 348 0.13604044136225 138 2849032
SGTC_2286 7945697 125 µM 1.09749112929449 0.0993381272958338 no 349 0.136213378201841 152 1245733
SGTC_2483 5729050 27.16 µM 1.09591378259253 0.0996698228191753 no 350 0.13655825345315 165 2865180
SGTC_257 daunorubicin 18.5 µM 1.09416976626702 0.100037508003895 no 351 0.136940264380393 159 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2724 maprotiline 69.64 µM 1.0936904792894 0.100138727768052 no 352 0.137045375644589 159 4011 A tricyclic antidepressant.
SGTC_1399 3562-5772 25 µM 1.09294326392719 0.100296679966731 no 353 0.137209355572061 147 23847490
SGTC_1009 4106-0057 9.87 µM 1.09245886375512 0.100399173349088 no 354 0.1373157310445 189 2928005
SGTC_1703 st026983 48.3 µM 1.0920705214695 0.100481397194013 no 355 0.137401052633617 152 1104023
SGTC_1809 st050081 57.6 µM 1.09174441793489 0.100550481149479 no 356 0.137472727878492 173 5036894
SGTC_2917 7979103 53.79 µM 1.08761668892531 0.101427923734908 no 357 0.138382180045252 142 2980565
SGTC_705 1124-0212 310 µM 1.08756294287734 0.101439385346062 no 358 0.138394048758525 194 9554485
SGTC_916 4466-0038 42 nM 1.0873755083409 0.101479364072018 no 359 0.138435445263409 199 5722064 YGL116W CDC20
SGTC_3071 9117417 49.47 µM 1.08716321259632 0.101524659411765 no 360 0.13848234276768 159 45595590 YGL055W OLE1
SGTC_1451 4152-0210 104 µM 1.08529666076577 0.101923540178019 no 361 0.138895142193016 168 659563
SGTC_642 0335-0876 158 µM 1.08496283639776 0.101994998270311 no 362 0.138969057740581 175 6812350
SGTC_869 0564-0080 44.1 µM 1.08359774422876 0.102287587816717 no 363 0.139271595724079 138 6843321
SGTC_1193 1488-0126 41.5 µM 1.08342631813082 0.102324373846113 no 364 0.139309619610949 163 1384710
SGTC_3216 9129716 49.47 µM 1.08297843791764 0.102420529090131 no 365 0.139408996898067 148 8056934
SGTC_800 3448-7362 155 µM 1.07846800816209 0.103392536145245 no 366 0.14041247564011 205 15991913
SGTC_326 k292-0812 17.5 µM 1.0783104725405 0.103426606013774 no 367 0.140447612523641 156 3579357
SGTC_1792 st045773 43.6 µM 1.07323864459945 0.104527836721752 no 368 0.141582027953194 87 2919270
SGTC_1982 st072467 71.9 µM 1.07297181272504 0.10458600743531 no 369 0.14164188162783 173 3163533
SGTC_713 1488-1073 324 µM 1.07230736796489 0.10473096168555 no 370 0.141790999244612 157 3312542
SGTC_1329 1447-1697 50.6 µM 1.07042240574752 0.105142973881191 no 371 0.142214609229153 163 2840515
SGTC_135 0933-0004 26.348 µM 1.06924492905072 0.105400939457258 no 372 0.142479659225191 168 21230617 YGL099W LSG1
SGTC_2045 5106652 78.05 µM 1.06818828114412 0.105632822940706 no 373 0.142717794931665 144 673349
SGTC_1138 3761-0006 1.03 µM 1.06790515464473 0.105695018226955 no 374 0.142781648557241 144 12061087
SGTC_2709 st078560 56 µM 1.0677240376753 0.105734818642585 no 375 0.142822506062167 187 17250903
SGTC_1086 cerivastatin 2.18 µM 1.06578405589177 0.106161808931002 no 376 0.143260635002926 166 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_864 0469-0573 172 µM 1.06487773776016 0.106361716032243 no 377 0.143465630270649 173 689425
SGTC_644 1498-1197 63.3 µM 1.06353505364322 0.106658372065909 no 378 0.143769688677953 172 6741615
SGTC_395 anisomycin 6.25 µM 1.06139807558308 0.107131752238587 no 379 0.144254515558287 173 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_897 1000-0139 31.4 µM 1.06072950871386 0.107280162865002 no 380 0.144406422742463 168 6151020
SGTC_4 0960-0234 25.671 µM 1.05865602410901 0.107741384241839 no 381 0.144878231139255 166 6821112
SGTC_1540 guanosine 70.6 µM 1.05633126671148 0.10826019480494 no 382 0.145408447979718 151 6802 Guanosine is a purine nucleoside
SGTC_989 1501-0895 10.3 µM 1.05390558014724 0.108803443768136 no 383 0.145963073935734 156 2830112
SGTC_234 nsc-17383 10.7 µM 1.05361627289065 0.108868366689365 no 384 0.146029317923958 170 408974
SGTC_1492 4158-0558 28.5 µM 1.05290649143447 0.109027765444627 no 385 0.146191925341428 148 3967268
SGTC_2443 5493264 126.67 µM 1.05126378126017 0.109397319316967 no 386 0.146568728382678 181 5340055
SGTC_1763 st044482 94.5 µM 1.04992069879551 0.109700135013888 no 387 0.146877287065514 181 88505
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.04984630114103 0.109716926520606 no 388 0.146894391849688 168 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_196 k015-0023 18.111 µM 1.04908725528232 0.109888348172854 no 389 0.147068980634096 150 5211998
SGTC_1271 0832-2808 169 µM 1.04778227328321 0.110183512266916 no 390 0.1473694657652 200 3663794
SGTC_2555 cholic acid 100 µM 1.04674469054236 0.110418600828086 no 391 0.147608672952773 137 6708657 Influences liver metabolism.
SGTC_1058 3448-5425 97.3 µM 1.04624141165024 0.110532759830111 no 392 0.147724793875882 187 7279705
SGTC_3133 9127736 49.47 µM 1.03977036217561 0.112008133803188 no 393 0.149223300879719 160 27243420
SGTC_2644 guaiazulene 100 µM 1.03175318196122 0.113855478291582 no 394 0.151093878373444 158 3515 A coloring agent.
SGTC_2809 7964133 12.99 µM 1.03088545299852 0.114056717845254 no 395 0.151297269551935 181 1253665
SGTC_1697 st025554 27.742 µM 1.0307128630063 0.114096774283732 no 396 0.151337745454932 175 1269519
SGTC_866 0495-0101 262 µM 1.02911787808038 0.114467428852098 no 397 0.151712143005513 166 635694
SGTC_2933 9026794 32.47 µM 1.02835712896396 0.114644519033287 no 398 0.151890933494893 178 17586027
SGTC_547 1120-0019 610 nM 1.02507277638101 0.115411301249143 no 399 0.152664424872565 176 3676939
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.02387601538087 0.115691607309933 no 400 0.152946920082864 158 88881 An O-methylated flavonoid and antioxidant.
SGTC_3262 9137218 49.47 µM 1.0226191681545 0.115986507038174 no 401 0.153243971520879 131 17650664
SGTC_1803 st050068 52.4 µM 1.0219985641677 0.116132318795912 no 402 0.1533907899922 187 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_639 0833-0042 114 µM 1.02146230411942 0.11625841857003 no 403 0.153517729941619 196 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2736 butenafine 14.65 µM 1.01997571498522 0.116608492977142 no 404 0.153869989197019 170 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2702 st077768 96.8 µM 1.01947622797894 0.11672628395161 no 405 0.15398846663232 167 6484119
SGTC_2806 7952793 58.44 µM 1.0190717315289 0.116821735683949 no 406 0.15408445669808 171 2972490
SGTC_1693 xanthone 101.9 µM 1.0173299264134 0.117233393170052 no 407 0.15449825236116 217 7020 An insecticide.
SGTC_147 4466-0538 29.23 µM 1.01483637664589 0.117824504464138 no 408 0.155091915215815 190 6742687 YHR072W ERG7
SGTC_2792 7535235 81.82 µM 1.01481254147159 0.117830164896266 no 409 0.15509759713765 181 1281891
SGTC_589 1227-0070 34.1 µM 1.01215356465875 0.11846283331092 no 410 0.155732317289699 170 2841384
SGTC_290 2043-6722 48.1 µM 1.01172815465159 0.118564276381913 no 411 0.155834024962113 173 773758 YLR208W SEC13
SGTC_1063 disulfiram 1.84 µM 1.01120040608052 0.11869020835332 no 412 0.155960260744995 192 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1758 st042942 75.2445 µM 1.00920401310779 0.119167444733369 no 413 0.156438401203555 193 669317
SGTC_2752 diclazuril 33.15 µM 1.00698922493114 0.119698471446413 no 414 0.156969976109031 173 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_732 3970-1727 52.7 µM 1.00658515787488 0.119795531947252 no 415 0.15706708491759 200 1275699
SGTC_3114 9122766 49.47 µM 1.00379734297427 0.120466702247746 no 416 0.157738152682917 147 17176985
SGTC_1560 lithocholic acid 53.1 µM 1.00239820757218 0.120804542268128 no 417 0.158075653742161 172 9903 A bile acid which acts as a detergent.
SGTC_350 k064-0020 19.8 µM 1.00216001722757 0.12086212288397 no 418 0.158133157475799 182 2790705
SGTC_1689 st020265 53.493 µM 1.00158571306517 0.12100103575502 no 419 0.158271862008062 180 5758320 YPR016C TIF6
SGTC_2474 5321570 43.32 µM 1.00141903211758 0.121041373619226 no 420 0.158312133324204 178 2841384
SGTC_857 0438-0306 1.35 µM 1.00093387015489 0.121158839785108 no 421 0.158429390206421 168 4686136
SGTC_2217 6934799 96.0675 µM 0.999457202690883 0.121516860059413 no 422 0.158786630635396 180 675606
SGTC_185 k048-0037 25.491 µM 0.99898516836107 0.121631462198199 no 423 0.158900938079171 162 6827589
SGTC_3009 9080819 71.4286 µM 0.998243988914965 0.121811561557294 no 424 0.159080530273205 171 17027216
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.996729756540793 0.12218008739319 no 425 0.159447850985351 160 77254
SGTC_1567 st069303 68.4 µM 0.995856821993767 0.122392892926053 no 426 0.159659858535023 194 5581319
SGTC_1764 st044502 93.5 µM 0.995108348664298 0.122575564113635 no 427 0.159841785306027 169 8407
SGTC_3314 9135860 59.4275 µM 0.994234055221805 0.122789184863625 no 428 0.160054466038434 179 25252478
SGTC_1303 1160-0052 261 µM 0.994092127271262 0.122823887489604 no 429 0.160089008898685 173 3562476
SGTC_3149 9097855 49.47 µM 0.993647012926739 0.122932766449779 no 430 0.160197373806576 168 25236625 YMR079W SEC14
SGTC_1825 st052143 62.6 µM 0.991342840976255 0.123497469384635 no 431 0.160759100276893 178 674173
SGTC_1421 4029-0249 71.4 µM 0.984382325239049 0.125214367087283 no 432 0.162463782558562 208 2894095
SGTC_1984 st072354 53.1 µM 0.980643773259645 0.126143376105069 no 433 0.16338422009934 197 5762938
SGTC_2032 5185112 25.99 µM 0.978996354723394 0.126554271628088 no 434 0.163790890325406 171 5718189
SGTC_2782 7736369 71.43 µM 0.977578806031904 0.126908579007917 no 435 0.164141341906136 199 2950836 YOL077C BRX1
SGTC_1794 st048918 76.9 µM 0.977467498614463 0.126936428805826 no 436 0.164168880312072 150 672303
SGTC_1790 st045711 43.5 µM 0.977000543462852 0.127053310203446 no 437 0.164284441657523 150 585119
SGTC_2034 5197015 53.07 µM 0.976832771476644 0.127095322721614 no 438 0.164325974488465 192 780676
SGTC_1948 st076329 66.6 µM 0.972870112232093 0.128090441121378 no 439 0.165308930502743 173 24208413
SGTC_251 melphalan 456.522 µM 0.971022043549779 0.12855638109085 no 440 0.165768650814674 211 460612 A DNA alkylator.
SGTC_1346 1488-2224 62.4 µM 0.970273898544246 0.128745339467843 no 441 0.165954992040502 191 3722427
SGTC_512 prima-1 270 µM 0.969078801685853 0.129047583702859 no 442 0.166252936730542 169 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1234 0326-0494 15.5 µM 0.968721395658431 0.12913806844985 no 443 0.166342107227482 209 1547813
SGTC_459 nigericin 15.3 µM 0.967646285409986 0.129410520027616 no 444 0.166610526439206 192 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1495 4469-0029 237 µM 0.967640752174471 0.12941192327492 no 445 0.166611908626453 174 793680
SGTC_2055 5235184 200 µM 0.967242197560789 0.12951302580982 no 446 0.16671148595361 192 2836034
SGTC_445 e6 berbamine 66 µM 0.965873343585593 0.129860683740136 no 447 0.16705378119858 217 6610268 A calcium/calmodulin antagonist.
SGTC_279 1273-0055 2.93 µM 0.962441700401255 0.130735082032495 no 448 0.167913887559061 213 2847562
SGTC_2075 5212009 200 µM 0.961529034977521 0.130968316900969 no 449 0.168143116878103 198 780898
SGTC_2491 paeonol 100 µM 0.961521148060224 0.130970333682728 no 450 0.168145098670259 185 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1867 st057372 64 µM 0.961297035980271 0.131027650866628 no 451 0.168201418913412 170 688837
SGTC_390 dec-rvkr-cmk 16.7 µM 0.960926776230754 0.13112238361876 no 452 0.168294493223135 186 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_449 xestospongin c 11.1929 µM 0.960921937887819 0.131123621845343 no 453 0.168295709684289 193 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1602 st001878 87.6 µM 0.955249567185293 0.132580850943535 no 454 0.16972575244416 213 595405 YLR310C CDC25
SGTC_852 0418-0143 439 µM 0.954475597425351 0.132780545052641 no 455 0.169921477909837 199 5369229
SGTC_2182 6325192 200 µM 0.95357057046722 0.133014316199704 no 456 0.170150529250309 186 736248
SGTC_85 0868-0259 160.055 µM 0.950340364794306 0.133850997306489 no 457 0.170969667530482 181 83173
SGTC_3249 9135183 49.47 µM 0.948913713860168 0.134221674609143 no 458 0.171332249537124 192 4902779
SGTC_2746 daunorubicin 9.88 µM 0.947632017257554 0.134555290107218 no 459 0.171658410397422 157 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2221 6807166 181.081 µM 0.946597956592059 0.134824862457094 no 460 0.171921842797011 168 674925
SGTC_1060 3448-7350 82 µM 0.946405275766666 0.134875133920048 no 461 0.171970957767065 190 570178
SGTC_2740 felodipine 17.08 µM 0.945943427491801 0.134995684964068 no 462 0.17208872086264 157 3333 L-type calcium channel blocker
SGTC_156 3474-0145 5.642 µM 0.945858450356411 0.135017873633971 no 463 0.172110394126019 184 2265471
SGTC_2284 7945075 39.21 µM 0.945791895219536 0.135035253819561 no 464 0.172127370108809 214 1245402
SGTC_1666 st014829 29 µM 0.943851662089205 0.135542600059685 no 465 0.172622728126087 184 3858230
SGTC_345 1362-0200 395 µM 0.941005735010251 0.136289133949143 no 466 0.173350960111823 190 1419823
SGTC_1845 st056753 3.01 µM 0.938637071965895 0.136912614976509 no 467 0.173958556157701 195 5375839
SGTC_1203 3992-3522 103 µM 0.938488259474445 0.136951850473441 no 468 0.17399677385142 211 5322312
SGTC_1324 1418-0026 34.4 µM 0.937517346569492 0.137208027334442 no 469 0.174246252566404 187 1372513
SGTC_1407 3909-7909 12.3 µM 0.937151662764543 0.13730459837102 no 470 0.174340274916257 191 4411780
SGTC_506 n9-isopropylolomoucine 153 µM 0.933317770321034 0.138319860403061 no 471 0.175327961349779 178 6610355
SGTC_3021 9087658 49.47 µM 0.933127837927162 0.138370289533642 no 472 0.175376983745667 180 25237042
SGTC_1686 st019653 115.5 µM 0.932978421735697 0.138409969974475 no 473 0.175415554835916 209 97252
SGTC_2763 lisinopril 49.32 µM 0.932744489680166 0.138472110858347 no 474 0.175475954100611 195 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2151 5563267 85.4165 µM 0.932367957731635 0.138572171396238 no 475 0.175573199124323 225 5310824
SGTC_1726 st035556 14.5795 µM 0.92915757080373 0.1394273081579 no 476 0.176403716204403 168 5919439
SGTC_2274 7947094 46.08 µM 0.928167417779626 0.139691773679457 no 477 0.176660366373536 194 2971028
SGTC_3125 9127534 49.47 µM 0.926447676467008 0.140151919200318 no 478 0.177106688507563 182 1639235
SGTC_2744 captopril 92.04 µM 0.925890645737086 0.140301182599641 no 479 0.177251406535796 137 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2504 purpurogallin 52.29 µM 0.925153347030928 0.140498917039755 no 480 0.177443073459043 191 5281571 An antioxidant.
SGTC_152 4469-0003 551.229 µM 0.922285635361942 0.141269800403803 no 481 0.178189802380864 214 697280
SGTC_3090 9117696 49.47 µM 0.92189824924973 0.14137415493468 no 482 0.178290826227316 186 7923821
SGTC_328 k915-0120 63.5 µM 0.916862239163675 0.142735515826747 no 483 0.179607416681313 171 6624543
SGTC_2934 9036370 36.88 µM 0.916770400278178 0.142760424205586 no 484 0.179631483189734 178 6462800
SGTC_380 3970-0968 6 µM 0.916169551181383 0.142923457923304 no 485 0.179788986530983 210 2891601
SGTC_72 0744-0168 198.391 µM 0.913371077372733 0.14368444997885 no 486 0.180523705836358 212 677577
SGTC_517 1365-0151 113 µM 0.911826550402082 0.14410562382131 no 487 0.180930015719409 191 768657
SGTC_2320 7373003 200 µM 0.910741752413115 0.144401932303107 no 488 0.181215729664852 211 5415828
SGTC_2331 7980721 200 µM 0.909213064798677 0.144820184099254 no 489 0.181618834589069 211 2981221
SGTC_283 0987-0079 11.7 µM 0.90467093956655 0.14606772705802 no 490 0.182819870486074 202 411556
SGTC_1256 0570-0116 285 µM 0.904419169043943 0.146137089060572 no 491 0.182886588743283 205 410638
SGTC_266 formosanin C 406 nM 0.902183994324218 0.146753842810016 no 492 0.18347956789028 220 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_24 0417-1663 219 µM 0.901776184083221 0.146866558357972 no 493 0.183587886762274 206 4329390
SGTC_322 k048-0136 19.3 µM 0.901428544100097 0.146962689158203 no 494 0.183680255212023 208 6823282
SGTC_2566 crystal violet carbinol 226 nM 0.901347147889044 0.146985203259966 no 495 0.183701886486651 245 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_584 0986-0246 15.4 µM 0.901157097335852 0.147037780037224 no 496 0.183752399140616 238 53315 YDR232W HEM1
SGTC_1569 carminic acid 40.6 µM 0.899559821431727 0.147480158818795 no 497 0.184177273570545 207 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.899407066830094 0.147522512138854 no 498 0.184217938212073 206 4213774
SGTC_2257 7960413 200 µM 0.898874707974842 0.147670179651898 no 499 0.184359700566991 211 2974689 YIL048W NEO1
SGTC_659 k018-0002 107 µM 0.898183309507463 0.147862109844762 no 500 0.184543915019919 207 6797879 YHR007C ERG11
SGTC_3349 9149703 23.001 µM 0.896721833016764 0.148268360857636 no 501 0.184933683682139 178 4910494
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.896101810110943 0.14844093586777 no 502 0.185099195203681 223 688801
SGTC_1717 st033143 58.0435 µM 0.8960026372965 0.148468551739262 no 503 0.185125677345222 195 674616
SGTC_3139 9095020 49.47 µM 0.894989468105596 0.148750877811113 no 504 0.185396358987363 172 25236292
SGTC_80 0159-0065 512.242 µM 0.890939221818408 0.149883087328 no 505 0.186480888602484 198 1548079
SGTC_2983 9022671 12.99 µM 0.89025377485637 0.150075264940025 no 506 0.186664817917471 199 6405161
SGTC_2248 tofa 1.1 µM 0.890029409717587 0.150138205487181 no 507 0.186725047295943 219 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1272 0839-0021 27 µM 0.888515102975201 0.150563469984566 no 508 0.187131867728844 221 5027250
SGTC_3261 9137475 49.47 µM 0.888462368191137 0.150578293996515 no 509 0.187146044866276 146 17027690
SGTC_650 1328-0195 38 µM 0.88756118897014 0.150831770235429 no 510 0.187388419148334 218 2780821
SGTC_792 4534-1957 155 µM 0.887521071917006 0.15084306062846 no 511 0.187399213233851 196 1717904
SGTC_2208 7283366 200 µM 0.886705437902629 0.15107273160654 no 512 0.187618754944441 221 898663
SGTC_2103 5378138 10 µM 0.885877340650421 0.151306149982936 no 513 0.187841813841545 217 244142
SGTC_1678 st019265 80.2 µM 0.885611757072182 0.151381061635599 no 514 0.187913386944763 202 5367020
SGTC_3119 9125183 49.47 µM 0.884944477633133 0.151569386176993 no 515 0.188093288843901 174 22695334
SGTC_1552 6-methylflavone 10.6 µM 0.884899088025884 0.151582202022758 no 516 0.188105529970919 208 689013
SGTC_2475 5812728 15.03 µM 0.883842332024599 0.151880782795253 no 517 0.188390665554417 206 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2050 5263056 171 µM 0.88175506607563 0.15247167600187 no 518 0.188954637769022 215 763468 YGL055W OLE1
SGTC_287 k060-0039 29.6 µM 0.881364439898765 0.152582429308943 no 519 0.189060299069479 225 5861974
SGTC_3007 9078383 71.4286 µM 0.880497135380587 0.152828524862915 no 520 0.189295028168864 205 6496995
SGTC_2359 9039622 200 µM 0.880377363234007 0.152862530592486 no 521 0.189327457644497 234 6463596
SGTC_452 diindolylmethane 8 µM 0.879776183790507 0.15303329336203 no 522 0.189490284494228 205 3071 Inhibits expression of several cancer promoting factors.
SGTC_557 1315-0110 16.2 µM 0.877521867036748 0.153674749335833 no 523 0.190101623460283 207 6833801
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.877283080418109 0.153742799139661 no 524 0.190166449946638 231 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1365 1672-3266 55.4 µM 0.875698052176226 0.154195008705501 no 525 0.190597102270118 223 6415873
SGTC_2919 7978188 46.38 µM 0.874154649458611 0.154636187029248 no 526 0.191017019742928 201 2980291
SGTC_2794 7785382 27.27 µM 0.873639048322631 0.154783756196925 no 527 0.19115742698714 224 2205081
SGTC_731 3966-0296 387 µM 0.873623710714204 0.154788147367565 no 528 0.191161604656211 196 660956
SGTC_19 0279-0214 38.434 µM 0.873410717516185 0.154849136012712 no 529 0.191219625686481 226 3566274 YBR002C RER2
SGTC_1924 st058459 75.1 µM 0.86845774161471 0.156271851259788 no 530 0.192571898296614 215 688683
SGTC_2627 acetyl isogambogic acid 100 µM 0.867269100356951 0.156614559117681 no 531 0.192897291441253 213 6857789 A caspase activator and apoptosis inducer.
SGTC_552 k242-0005 476 µM 0.865879106105473 0.157015947973793 no 532 0.193278231104742 240 4088318
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.864695725643883 0.157358205746164 no 533 0.193602908063774 209 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.864584471415407 0.157390407939747 no 534 0.193633449311236 215 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1293 1000-1278 195 µM 0.863784019418453 0.157622223990674 no 535 0.193853274101098 222 678847
SGTC_1512 0259-0544 12.2 µM 0.863018750153738 0.15784406054271 no 536 0.194063578970475 208 18476
SGTC_610 4215-0184 155 µM 0.862304494808726 0.158051294060475 no 537 0.194259989979487 217 5605015
SGTC_1611 st001856 99.4 µM 0.861963293991723 0.158150352824055 no 538 0.194353858515444 233 647478
SGTC_1041 0206-0046 107 µM 0.861355198127738 0.158326998612038 no 539 0.194521221610688 227 50494
SGTC_2543 pimpinellin 60.67 µM 0.858220733463791 0.159239581934407 no 540 0.195385294704346 211 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1954 st077032 68.9 µM 0.857054702212774 0.159579943351209 no 541 0.195707326856747 239 698907
SGTC_692 k241-0027 77.8 µM 0.856701135224933 0.159683242620904 no 542 0.195805037896375 217 3600480
SGTC_1849 st056239 19.2 µM 0.856329548645319 0.159791853699094 no 543 0.195907760695635 232 5393181
SGTC_3246 9135460 32.98 µM 0.85603063899351 0.159879257097519 no 544 0.19599041613624 220 41446951
SGTC_406 estrone 100 µM 0.855382383490369 0.160068919243629 no 545 0.196169746472495 215 5870 A steroid.
SGTC_2507 purpurin 79.67 µM 0.853704980045472 0.160560364980925 no 546 0.19663423705864 252 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1841 st054148 70 µM 0.853160709879586 0.160720036841214 no 547 0.196785094215051 222 675442
SGTC_716 1683-5115 658 µM 0.852947021534832 0.160782754662238 no 548 0.196844342073674 237 723597
SGTC_3308 9128332 17.569 µM 0.852308748243518 0.160970183884176 no 549 0.197021375905583 210 17332805 YDL196W YDL196W
SGTC_1410 3909-8106 77.9 µM 0.850055742385396 0.161632919665676 no 550 0.197647047949135 231 1039210
SGTC_86 0417-1630 471.922 µM 0.84970257459339 0.161736967208688 no 551 0.197745233341345 235 3634867
SGTC_1973 st070275 50.2 µM 0.84909104903447 0.161917233308824 no 552 0.197915315352935 200 17118334
SGTC_3238 9133470 49.47 µM 0.848417722176838 0.162115868601083 no 553 0.198102688176746 187 3534688
SGTC_2595 hexamethylquercetagetin 100 µM 0.84840460897257 0.162119738646384 no 554 0.198106338371034 237 386331
SGTC_1292 0kpi-0043 232 µM 0.847638828892288 0.162345844470263 no 555 0.198319571499944 229 3333905
SGTC_1136 pergolide 1.05886 µM 0.847158449208309 0.162487787097275 no 556 0.198453404939292 232 47811 A dopamine receptor agonist.
SGTC_1119 parthenolide 318.541 nM 0.845575584949695 0.162956063231972 no 557 0.19889477522803 247 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3214 9129694 49.47 µM 0.845266857771338 0.16304749953794 no 558 0.198980930479108 239 17158655
SGTC_742 0kpi-0133 140 µM 0.84351615210793 0.163566639943768 no 559 0.199469918085919 231 2728852
SGTC_906 1165-0455 526 µM 0.84326621051793 0.163640843105525 no 560 0.199539787946297 220 3252859
SGTC_986 1493-0483 84 µM 0.842924958791531 0.163742189889104 no 561 0.199635206857409 221 40079
SGTC_2303 7774051 200 µM 0.842675561741424 0.163816282937252 no 562 0.199704959236706 238 2953184
SGTC_3144 9087057 49.47 µM 0.841350780971648 0.16421022507095 no 563 0.200075725046596 213 17249618
SGTC_715 0868-0130 184 µM 0.840797815123463 0.164374838804281 no 564 0.200230605680736 226 2876258
SGTC_3064 1327-0027 10 µM 0.837712189276996 0.16529536946998 no 565 0.201096182955048 195 16000455 YPR107C YTH1
SGTC_2211 7117706 200 µM 0.836605797907017 0.165626248693952 no 566 0.201407092756146 212 822771
SGTC_1832 st054113 55 µM 0.836241661540424 0.165735241532836 no 567 0.201509482604271 216 1251267
SGTC_1720 st037298 9.481 µM 0.834360097438711 0.166299167613871 no 568 0.202039047819629 223 597396
SGTC_2536 dehydroabietamide 32.04 µM 0.832947547366986 0.16672333824984 no 569 0.202437156090254 209 3983547
SGTC_2999 9069765 71.4286 µM 0.832577398920522 0.166834604407006 no 570 0.202541554968283 209 2097066
SGTC_959 1222-0044 107 µM 0.83200225746949 0.167007586224289 no 571 0.202703835139894 223 6083612
SGTC_310 1273-0058 1.06 µM 0.831385179374697 0.167193309647633 no 572 0.202878034402078 193 2734232
SGTC_2096 5468907 200 µM 0.831247134871862 0.167234875438555 no 573 0.20291701618013 217 759785
SGTC_2025 5147754 141 µM 0.829821791822557 0.167664441741227 no 574 0.203319774022216 217 315777 YLR208W SEC13
SGTC_288 1315-0019 35.1 µM 0.828478221694944 0.168070013581734 no 575 0.203699861792632 246 6811474
SGTC_2856 9022925 19.48 µM 0.828170464285998 0.168163002430403 no 576 0.203786984076746 226 4944862
SGTC_2066 5222451 176 µM 0.826935356234345 0.168536523033135 no 577 0.204136851143679 229 2281147
SGTC_3084 9116877 49.47 µM 0.824681678242138 0.169219452370089 no 578 0.204776168112166 222 27241325
SGTC_46 0329-0187a 2.197 µM 0.822912535857699 0.169756796439492 no 579 0.205278866703088 229 46494817
SGTC_1946 st076057 65.1 µM 0.822663971128811 0.1698323809285 no 580 0.205349554609336 214 953009
SGTC_1398 3558-0053 112 µM 0.820400367641262 0.170521698762362 no 581 0.205993952985061 217 4532369
SGTC_1506 4226-2149 212 µM 0.820302442409325 0.170551559555174 no 582 0.206021857193035 221 991114
SGTC_1939 st074455 53.6 µM 0.820268123074394 0.170562025500588 no 583 0.206031637162777 214 1644229
SGTC_3118 9124250 49.47 µM 0.818621209122912 0.171064747892316 no 584 0.206501281243362 219 1504786
SGTC_2003 4023581 200 µM 0.817222452286798 0.171492463554179 no 585 0.206900656922709 212 16641307
SGTC_2430 5571206 200 µM 0.816590074911739 0.171686057761681 no 586 0.207081364452685 248 1731771
SGTC_2565 isoliquiritigenin 100 µM 0.815620697882594 0.171983090997379 no 587 0.207358553867376 233 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1332 1480-0653 17.5 µM 0.815107410171744 0.172140503656587 no 588 0.207505415184513 220 5749438
SGTC_2533 agelasine 13.65 µM 0.814956445239478 0.172186818365135 no 589 0.207548620801864 216 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_295 k015-0027 31 µM 0.814815706069961 0.172230003061603 no 590 0.20758890463091 217 3887424
SGTC_2669 eugenol 100 µM 0.814798898460468 0.172235160805016 no 591 0.207593715788541 220 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_67 0335-0847 266 µM 0.813017661536384 0.172782326805224 no 592 0.208103966084221 245 4552207 YOR254C SEC63
SGTC_235 0330-0087 5 mM 0.812553680093869 0.172925035782214 no 593 0.208236998888597 234 46494818 YHR062C RPP1
SGTC_417 st075190 100 µM 0.811484585596837 0.173254148067708 no 594 0.208543720710501 245 222757
SGTC_1644 st010134 20.9 µM 0.81143678593783 0.173268872123691 no 595 0.208557440588776 242 3818134
SGTC_2469 5655019 90.81 µM 0.810341026044623 0.173606625011254 no 596 0.208872101129327 234 2788239
SGTC_1158 4092-0494 91.8 µM 0.8095383210248 0.173854313438801 no 597 0.20910278485489 222 1148199
SGTC_1294 1000-1494 117 µM 0.808031829112665 0.174319773767495 no 598 0.209536129680545 218 712797 YDL207W GLE1
SGTC_1659 st012954 42.1 µM 0.807641603613524 0.174440470608161 no 599 0.209648464757048 233 24207262
SGTC_2619 obliquin 87.91 µM 0.807461638248338 0.174496151820465 no 600 0.209700283715357 233 6708593 A bioactive alkalod. YER133W GLC7
SGTC_418 lividomycin a 100 µM 0.806677496713938 0.174738896629246 no 601 0.209926156139991 221 72394 An antibiotic.
SGTC_2745 rifampicin 24.3 µM 0.806077241690534 0.174924860919089 no 602 0.210099156527544 185 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2037 5169046 200 µM 0.805419101056561 0.17512890296472 no 603 0.210288936439109 223 5718022
SGTC_3204 9114183 49.47 µM 0.805247252066747 0.17518220581555 no 604 0.210338506985208 227 17027248
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.804623825030973 0.175375662171524 no 605 0.210518394652439 222 688664
SGTC_2941 9056145 11.23 µM 0.804178001201596 0.175514089302082 no 606 0.2106470908954 226 2119517
SGTC_1400 3771-8998 51.5 µM 0.803144770232792 0.175835170952974 no 607 0.210945531721018 215 670767
SGTC_3269 9137823 49.47 µM 0.802987918166632 0.175883946016704 no 608 0.21099085889851 192 17682936
SGTC_997 3996-0078 137 µM 0.802358630857267 0.176079716721916 no 609 0.211172768013138 229 735687
SGTC_2114 5491910 81.25 µM 0.802033620807806 0.176180881051343 no 610 0.211266755180578 233 2849228
SGTC_323 4013-0906 34.3 µM 0.800655406289689 0.176610279966055 no 611 0.211665582698197 214 2910086
SGTC_3136 9095672 49.47 µM 0.800536846528367 0.176647249541039 no 612 0.211699912077815 229 17217380
SGTC_318 1488-0629 67.2 µM 0.796148327796558 0.178019129156913 no 613 0.212972913560091 234 3662576
SGTC_1444 4112-3581 28 µM 0.795933571453547 0.178086435359579 no 614 0.213035323525613 235 2877249
SGTC_801 0866-0028 10.1 µM 0.794232860170004 0.178620017120545 no 615 0.213529940961543 241 6849771
SGTC_1603 st002045 67.8 µM 0.792724450137777 0.179094107741942 no 616 0.213969190932021 245 5887985
SGTC_1843 st055809 45.5 µM 0.791983923442493 0.179327143423896 no 617 0.214185025141236 243 16413835
SGTC_1702 st027038 51 µM 0.791848931751139 0.179369644375751 no 618 0.214224383520078 230 5521182
SGTC_2263 7948595 193.29 µM 0.790090965077116 0.179923702948004 no 619 0.214737322971738 234 2971371
SGTC_564 3555-0129 330 µM 0.789643417228878 0.180064928122924 no 620 0.214868022345507 242 563260
SGTC_2336 9001819 198.65 µM 0.788464922664211 0.180437138702689 no 621 0.215212404279149 258 2989602
SGTC_2276 7947513 42.08 µM 0.787841900965288 0.180634106048178 no 622 0.215394594244482 247 2105100
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.786759798604515 0.18097653135426 no 623 0.215711245552086 245 688664
SGTC_2843 9000894 45.46 µM 0.78550609473455 0.181373767281374 no 624 0.216078449159133 178 2242070
SGTC_3252 9135871 49.47 µM 0.781125184660243 0.182766140388689 no 625 0.217364435422925 258 17682838
SGTC_3317 9138495 8.753 µM 0.780115109764412 0.18308811398152 no 626 0.217661561723969 258 17020139
SGTC_63 0099-0242 26.702 µM 0.78002495239776 0.183116869924408 no 627 0.217688094041031 261 3898502 YLR359W ADE13
SGTC_2918 7977171 22.06 µM 0.777542083071912 0.183909894882229 no 628 0.218419508034935 245 2236483
SGTC_2825 7998094 58.44 µM 0.776867147951888 0.184125837382004 no 629 0.218618577636436 231 2987815
SGTC_435 c-PAF 6.7 µM 0.776666118536358 0.184190186345995 no 630 0.218677890695861 238 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2608 thymoquinone 42.66 µM 0.776234737317121 0.184328317526146 no 631 0.218805199546471 245 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2963 9082507 9 µM 0.774611012897638 0.184848822719207 no 632 0.21928477388669 235 16459611
SGTC_1314 1222-0010 41.1 µM 0.773561464548978 0.185185754162427 no 633 0.219595083919141 255 3526027
SGTC_665 3914-0008 307 µM 0.773136446833156 0.185322303983907 no 634 0.219720816592425 245 1069549
SGTC_1885 st057546 99.9 µM 0.772616635588902 0.18548939405991 no 635 0.219874648137744 225 702008
SGTC_2641 levomentholum 100 µM 0.772189103057361 0.185626891776047 no 636 0.220001217281539 242 16666
SGTC_2223 6903751 107.57 µM 0.770868223844063 0.186052095962921 no 637 0.220392521794595 241 5598863
SGTC_1642 st009582 77.7 µM 0.770855357561356 0.186056240714709 no 638 0.220396335333722 265 6739311
SGTC_694 1315-0438 43.2 µM 0.770714957833929 0.18610147288465 no 639 0.22043795197579 246 6793154
SGTC_3176 9106582 49.47 µM 0.770252319742823 0.186250567876042 no 640 0.22057511690054 206 17018027
SGTC_1972 st070201 17.4 µM 0.769123426232399 0.186614688430593 no 641 0.220910021251626 232 2829099
SGTC_2181 6316240 54.2555 µM 0.768931676459524 0.186676580395213 no 642 0.220966935802442 245 12779990
SGTC_1328 1441-0025 69.2 µM 0.767393531992088 0.187173514139447 no 643 0.221423786488331 234 4562601
SGTC_3142 9086498 49.47 µM 0.767228360876142 0.187226925151187 no 644 0.221472876737555 249 25236367
SGTC_712 r015-0009 80.6 µM 0.762738188708287 0.188682510686918 no 645 0.222809775344137 247 6813872 YLR060W FRS1
SGTC_3056 9094900 49.47 µM 0.762654783507322 0.188709614093762 no 646 0.222834651734384 257 25236784
SGTC_1157 4092-0394 27.6 µM 0.762591855375485 0.188730064847529 no 647 0.222853421692399 252 3659885
SGTC_155 k072-0202 43.6 µM 0.762554268401449 0.188742280734662 no 648 0.222864633418283 261 5857737
SGTC_1172 0370-0043 85 µM 0.76201261241223 0.18891837477907 no 649 0.223026238328981 238 376585
SGTC_670 4204-0025 119 µM 0.761467261558803 0.189095772259899 no 650 0.223189013015145 230 719039
SGTC_2015 5119600 184 µM 0.76100812693846 0.189245203932082 no 651 0.223326106560701 264 2828786
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.757977624155344 0.1902333453242 no 652 0.224232189105207 246 94937 An inhibitor of serotonin biosynthesis.
SGTC_2751 anetholtrithion 17.25 µM 0.756304073254215 0.190780388030138 no 653 0.224733453261783 246 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3277 9138724 49.47 µM 0.752269612905353 0.192103117141641 no 654 0.22594446893138 224 15943418
SGTC_2312 7706453 155.7 µM 0.75138040366729 0.192395404191198 no 655 0.226211876401967 236 976098
SGTC_1217 1183-1422 255 µM 0.75030159636107 0.192750377835496 no 656 0.22653654069559 253 2849664
SGTC_985 1493-0307 8.71 µM 0.749548138379859 0.192998534842483 no 657 0.226763447880039 257 3278274
SGTC_84 0443-0269 128.823 µM 0.747930199551502 0.193532073962181 no 658 0.227251130359506 239 6150058
SGTC_2329 6138490 200 µM 0.747905145925849 0.19354034283067 no 659 0.227258686719544 251 720019
SGTC_708 3448-5400 146 µM 0.743829908464226 0.194888228695758 no 660 0.228489691823647 266 3462195
SGTC_143 4032-1194 15.74 µM 0.743159751159615 0.195110428708 no 661 0.228692483990356 261 1806963
SGTC_1838 st055369 84.5 µM 0.742578858266702 0.195303156390791 no 662 0.228868346140242 242 676036
SGTC_3034 9090421 49.47 µM 0.742489481474967 0.195332819938839 no 663 0.228895411211636 235 17173761
SGTC_500 h-89 112 µM 0.741148600677747 0.195778177639247 no 664 0.229301672157369 253 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1802 st050112 57.9 µM 0.74065084864382 0.195943656816276 no 665 0.229452584218465 254 4662563
SGTC_1742 st038235 28.8875 µM 0.739304693387509 0.19639161512934 no 666 0.229861000001608 271 564103 YBR002C RER2
SGTC_619 1652-1634 108 µM 0.739134358178474 0.196448341559794 no 667 0.229912707718124 255 5400454
SGTC_60 0986-0278 202 µM 0.7384157555525 0.196687765800197 no 668 0.230130921600508 264 3110598
SGTC_3004 9076122 71.4286 µM 0.73726015857173 0.197073158406088 no 669 0.23048207788239 267 44782551
SGTC_629 3448-6466 76.7 µM 0.736619196857435 0.197287116599547 no 670 0.230676978766304 272 573744
SGTC_3024 9090631 49.47 µM 0.734603472243434 0.197960896972738 no 671 0.231290511360499 245 25236383
SGTC_1358 1509-0022 2.48 µM 0.734392276333392 0.198031572114264 no 672 0.231354846378639 272 3258434
SGTC_2545 solidagenone 89.61 µM 0.733902369997421 0.19819557428719 no 673 0.231504121273467 214 6708572 An anti ulcer agent
SGTC_3069 9117009 49.47 µM 0.732496425542692 0.198666686572843 no 674 0.231932811817464 239 41904981
SGTC_1652 st011932 78 µM 0.731653842226892 0.198949347783399 no 675 0.232189938013809 254 1551076
SGTC_1267 0828-0272 9.49 µM 0.731245694640079 0.199086356043926 no 676 0.232314547024798 258 745334
SGTC_2831 7999036 19.48 µM 0.731199578211186 0.19910184012473 no 677 0.232328628884969 258 2988270
SGTC_1974 st069448 26.9 µM 0.729581259781423 0.19964566706787 no 678 0.232823090347884 244 6323587 YNR016C ACC1
SGTC_2395 5646831 180.19 µM 0.729522467369734 0.199665440742836 no 679 0.232841064797785 272 6808628
SGTC_2768 sulfasalazine 50.2 µM 0.729331193681673 0.199729780050339 no 680 0.232899547734974 272 5384001 An antioxidant and salicylic acid derivative.
SGTC_1624 st003710 6.25 µM 0.728602459551509 0.199975020808066 no 681 0.23312243678183 260 24207033
SGTC_746 1095-0025 46.6 µM 0.727599232997667 0.200312932491407 no 682 0.233429475133744 273 6749286
SGTC_3039 9090270 49.47 µM 0.726283438177249 0.200756644617112 no 683 0.233832515115879 241 17173750
SGTC_1568 digitonin 820 nM 0.724700919458752 0.201291082041152 no 684 0.234317765468627 282 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1105 epirubicin 18.1 µM 0.723443131405379 0.201716461368676 no 685 0.234703840306225 267 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2583 asiatic acid 100 µM 0.723069695638311 0.201842859559189 no 686 0.23481853314161 288 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2122 5258151 111.688 µM 0.72273333133196 0.201956750619064 no 687 0.234921866782291 251 2173356
SGTC_136 0097-0015 404.482 µM 0.71940191131191 0.203086826490996 no 688 0.235946659774203 266 4861337
SGTC_1115 galangin 695.678 nM 0.71773002749336 0.203655378646956 no 689 0.236461882450817 278 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2477 5967686 25.23 µM 0.717112232216925 0.203865710220186 no 690 0.236652424338828 257 776118
SGTC_968 1309-0633 340 µM 0.715855169250692 0.204294083279378 no 691 0.237040391340143 269 3761976
SGTC_98 0074-0023 107.663 µM 0.714866479231022 0.204631378318902 no 692 0.237345775873293 262 3563821
SGTC_2149 5554786 194.827 µM 0.714762259936177 0.204666952386754 no 693 0.237377979496189 262 745063 YPR165W RHO1
SGTC_3205 9113483 49.47 µM 0.714629507167347 0.20471227135807 no 694 0.237419003398533 268 17018033
SGTC_835 0312-0010 67.2 µM 0.714412967047458 0.204786206356638 no 695 0.237485928025014 274 1626196
SGTC_3194 9111903 49.47 µM 0.714234660977013 0.20484709872351 no 696 0.237541043679213 268 17087251
SGTC_1456 k015-0012 13 µM 0.71390706021997 0.204959003992052 no 697 0.237642325661493 270 2989616
SGTC_1143 3454-2408 5.08 µM 0.713408078269808 0.205129521246698 no 698 0.237796637861294 245 X1143
SGTC_2915 7971052 15.16 µM 0.713309045036629 0.205163373927534 no 699 0.237827270826713 238 5741558
SGTC_132 0417-1715 25.805 µM 0.712818409730512 0.205331137499606 no 700 0.237979066083289 263 6769098
SGTC_1322 1348-1070 12 µM 0.710770895939995 0.20603212564263 no 701 0.23861310930028 266 6758089
SGTC_1022 4477-0945 21.3 µM 0.708180407818176 0.20692103749785 no 702 0.239416615642657 255 4648966
SGTC_2989 9073649 71.4286 µM 0.707266783195996 0.207235083408791 no 703 0.239700351831769 285 21367202
SGTC_2400 5203494 178.7 µM 0.706413112461102 0.20752877557766 no 704 0.239965634428035 283 6777674
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.706273009744596 0.207576999230125 no 705 0.240009187361053 254 17037758
SGTC_1483 3453-0561 55.9 µM 0.7060740311161 0.207645499475868 no 706 0.240071050120238 280 4546991
SGTC_1923 st058458 19.1 µM 0.7058811403758 0.207711916656839 no 707 0.240131028442805 294 3534982
SGTC_1882 5615643 20 µM 0.70565072874957 0.207791269678553 no 708 0.240202684384472 255 2253075
SGTC_1500 4488-1866 171 µM 0.703339658759681 0.208588184719359 no 709 0.240922050558927 291 2900003
SGTC_1921 5740136 50 µM 0.702900006121138 0.208739991739135 no 710 0.241059033674003 268 1774243
SGTC_114 0364-0001 490.298 µM 0.701592737417385 0.209191761107513 no 711 0.241466591052154 272 4003655
SGTC_2571 chrysanthemic acid 100 µM 0.701094395204839 0.209364130949834 no 712 0.241622053945843 290 2743 An insecticide.
SGTC_2585 alliin 100 µM 0.701026556098153 0.209387602042474 no 713 0.241643221242813 277 87310 A garlic compound which reacts with lipids.
SGTC_2318 6029776 164 µM 0.700644833115588 0.209519700092063 no 714 0.241762345996858 280 818325
SGTC_3237 9133362 49.47 µM 0.698216801744169 0.210361085180489 no 715 0.242520810258037 273 43845137
SGTC_269 exalamide 29 µM 0.697994933506137 0.210438067915171 no 716 0.242590181281282 263 3316 A derivative of salicylamide.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.697657945698207 0.21055502589272 no 717 0.24269556702266 266 803109
SGTC_1139 k015-0024 46.9 µM 0.697050240628292 0.210766037800809 no 718 0.242885676437723 271 2766652
SGTC_1795 st049545 62.3 µM 0.69678400233719 0.210858522115832 no 719 0.242968989593328 229 5291882
SGTC_2847 9005661 71.43 µM 0.696431044314116 0.210981167309999 no 720 0.243079463524751 247 2991449
SGTC_938 3126-1755 342 µM 0.695774678900399 0.211209351102352 no 721 0.24328497451798 264 1777771
SGTC_2256 7954252 200 µM 0.695189904563631 0.211412768188785 no 722 0.243468149095586 276 2972920
SGTC_2780 5215298 71.43 µM 0.694880868926504 0.211520314320461 no 723 0.243564981429939 285 2834131
SGTC_3354 9151612 71.43 µM 0.693859388870092 0.211876022948971 no 724 0.243885196990758 256 27261949
SGTC_2288 7946289 167.31 µM 0.693622218659259 0.211958662444517 no 725 0.243959578054267 274 1246052
SGTC_3048 9093155 49.47 µM 0.69316758710529 0.212117126782356 no 726 0.244102193317288 249 25236002
SGTC_186 3455-3465 67.277 µM 0.692896099186159 0.212211788419037 no 727 0.244187378928665 273 755278
SGTC_1125 tnp00248 1.32998 µM 0.69239285192713 0.212387324543115 no 728 0.244345326775389 280 24207736
SGTC_1600 coumarin 106 71.1 µM 0.691471789727368 0.212708817057422 no 729 0.244634551462204 291 100336 A hepatotoxic, DNA x-linker.
SGTC_699 0375-0592 111 µM 0.691414288315583 0.212728897078712 no 730 0.244652613714082 242 762578
SGTC_2462 5162487 171.77 µM 0.69122495944992 0.212795020278694 no 731 0.244712090470498 263 2259986
SGTC_740 k014-0057 261 µM 0.690096193160484 0.213189491387981 no 732 0.245066848503257 275 4012779
SGTC_3270 9137563 49.47 µM 0.689538628761373 0.213384501243492 no 733 0.245242186485873 253 17015724
SGTC_2188 6126565 140.678 µM 0.687680136117028 0.214035265231562 no 734 0.24582711578411 263 874518
SGTC_2970 9090938 41.86 µM 0.687145527079592 0.214222675981384 no 735 0.245995513572492 266 17217104
SGTC_56 0957-0365 83.25 µM 0.687096691049808 0.214239800533608 no 736 0.2460108996357 259 6752360
SGTC_522 1273-0010 11.6 µM 0.686652969430168 0.214395429807893 no 737 0.246150720257645 275 5705015
SGTC_1071 trifluoperazine 6.31 µM 0.685594232045798 0.214767032902383 no 738 0.246484509897792 290 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2658 polymyxin b sulfate 77.05 µM 0.683840527656628 0.215383383026555 no 739 0.247037935913582 273 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_979 1426-2828 121 µM 0.683294516907141 0.21557549113464 no 740 0.247210379102854 265 747872
SGTC_537 1334-0398 209 µM 0.683058892534607 0.215658423760997 no 741 0.24728481476492 278 5846986
SGTC_206 4546-0025 72.014 µM 0.682778267585582 0.215757219354626 no 742 0.247373482107963 297 6620745 YIL048W NEO1
SGTC_1285 0929-0069 65.5 µM 0.67836889489267 0.217313005046653 no 743 0.248768913019885 269 1206237
SGTC_1525 8-methoxypsoralen 92.5 µM 0.678112803645 0.217403561895679 no 744 0.248850086610675 287 4114 Related to psoralen; DNA damaging agent.
SGTC_2402 5553605 200 µM 0.676743136190269 0.217888261998397 no 745 0.249284471226347 285 6758546
SGTC_806 3966-4455 5.86 µM 0.676550400525871 0.217956517584457 no 746 0.24934562892041 273 714982
SGTC_886 0866-0150 153 µM 0.675685529015799 0.218262955726227 no 747 0.249620162793168 272 271463
SGTC_1162 k048-0130 20.1 µM 0.674786523642112 0.218581751022589 no 748 0.249905701791023 280 6797406
SGTC_542 3381-0244 89.3 µM 0.674489016222452 0.218687308805145 no 749 0.250000233239682 299 1112843
SGTC_2840 9008771 71.43 µM 0.673818575019676 0.21892529372081 no 750 0.250213332015355 227 2992978
SGTC_57 miconazole 162.5 nM 0.673587333816766 0.219007411400456 no 751 0.250286854036178 270 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1514 1189-1591 158 µM 0.673274891841433 0.219118392987364 no 752 0.250386211640392 301 767698 YMR146C TIF34
SGTC_531 3788-1495 174 µM 0.672967012381711 0.219227785561558 no 753 0.250484138796609 269 2896655
SGTC_2638 epoxomicin 18 µM 0.672736440461152 0.219309730567829 no 754 0.250557490048827 276 9915668 A protesome inhibitor.
SGTC_61 0978-8327 98.565 µM 0.672624259973764 0.219349605754273 no 755 0.250593181853751 287 6150059 YHR072W ERG7
SGTC_3215 9129942 49.47 µM 0.672444873464672 0.219413378357093 no 756 0.250650261799432 290 17682944
SGTC_1448 4255-0083 152 µM 0.671812256702516 0.21963836108961 no 757 0.250851612438542 306 5399660
SGTC_1048 3161-0300 24.5 µM 0.671339224312675 0.219806676040088 no 758 0.251002226147125 266 2165101
SGTC_2176 5809774 33.9695 µM 0.670865486876608 0.219975316041476 no 759 0.251153112286979 261 2870539
SGTC_2089 5281248 129.67 µM 0.670081246205557 0.220254651402628 no 760 0.251402999617083 273 2737878
SGTC_1725 st036284 20.55 µM 0.668881969433006 0.220682209794452 no 761 0.251785386388372 277 707914
SGTC_942 3253-1115 227 µM 0.668515385590107 0.220812996699418 no 762 0.251902332093066 314 46497897
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.667422538791949 0.221203157272934 no 763 0.25225113655493 311 6708760
SGTC_2121 5257820 149.641 µM 0.666852936103447 0.221406669110693 no 764 0.2524330378416 255 791256
SGTC_3164 9100705 49.47 µM 0.666285200203054 0.221609620458033 no 765 0.252614411741258 252 17174235
SGTC_633 0437-0093 97.7 µM 0.666157837954757 0.22165516386412 no 766 0.252655109429269 292 2831118
SGTC_737 1950-0117 57.9 µM 0.665210507796879 0.22199408700375 no 767 0.252957930287878 278 5393513
SGTC_1779 st039427 55 µM 0.665187830596395 0.222002203774457 no 768 0.25296518155722 299 1124498
SGTC_249 wiskostatin 11.211 µM 0.664891932998896 0.222108128890567 no 769 0.253059807898149 266 2775510 A n-wasp and actin depolymerizer.
SGTC_3190 9110366 49.47 µM 0.664598611259624 0.222213160370478 no 770 0.25315362887072 265 17123768
SGTC_609 0986-0026 86.3 µM 0.664240684053059 0.222341363904565 no 771 0.253268139123376 278 2848610
SGTC_1464 k208-0027 110 µM 0.663411587873338 0.222638494292159 no 772 0.253533493193737 278 X1464
SGTC_2292 7671323 168.05 µM 0.662627849818232 0.222919577294777 no 773 0.253784464528832 301 937504
SGTC_1102 cgs 12066b 26.1 µM 0.661987293261411 0.223149459155443 no 774 0.253989682608308 279 6438352 A 5-HT1B full agonist.
SGTC_592 k241-0073 46.5 µM 0.661552330578502 0.223305634741418 no 775 0.254129083244398 281 4230158
SGTC_2110 5483698 200 µM 0.660954230295028 0.223520487263669 no 776 0.254320833149621 269 2848765 YHR062C RPP1
SGTC_199 4063-0024 41.6 µM 0.660750572322251 0.223593673108283 no 777 0.254386142845047 277 306215
SGTC_2028 5153890 36.43 µM 0.660638785889309 0.223633850097433 no 778 0.254421994615083 287 2830968 YPR165W RHO1
SGTC_83 0170-0301 39.027 µM 0.660179610875442 0.223798924537377 no 779 0.254569287458677 284 3089716
SGTC_3087 9117406 49.47 µM 0.659461367074619 0.224057273632228 no 780 0.254799773195839 261 42546093
SGTC_2150 5556613 200 µM 0.659045467533703 0.224206948261921 no 781 0.254933286038313 304 743190
SGTC_1871 st057448 67.3 µM 0.65895744767133 0.224238632276685 no 782 0.254961547031008 305 691747
SGTC_2461 5755302 26.15 µM 0.657417805545913 0.224793259600362 no 783 0.255456152898049 312 2788904
SGTC_900 1112-0045 141 µM 0.656935934876834 0.224967004195909 no 784 0.255611055492823 274 56211 YIL048W NEO1
SGTC_3003 9075612 71.4286 µM 0.654780676167251 0.225745040966777 no 785 0.256304486912163 304 6501993
SGTC_2269 7935389 174.42 µM 0.652912017138914 0.226420846999337 no 786 0.256906500620547 280 97605
SGTC_1900 st060200 72.8 µM 0.652328054502235 0.22663227287617 no 787 0.257094782840197 282 688945
SGTC_2976 9009005 19.48 µM 0.651365403894835 0.226981047292204 no 788 0.257405318858166 265 2993148
SGTC_3265 9137266 49.47 µM 0.649127565195334 0.227792998984983 no 789 0.258127963006824 244 17224265
SGTC_165 k038-0023 64.381 µM 0.648880681670898 0.227882675371712 no 790 0.258207751153348 286 46368543
SGTC_444 curcumin 90.4 µM 0.647393838957748 0.228423166414166 no 791 0.258688541173152 279 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3124 9127567 49.47 µM 0.646151145205111 0.228875457467483 no 792 0.259090737676972 280 17592030
SGTC_1636 st007707 68.9 µM 0.645006516226374 0.229292501168567 no 793 0.259461481473651 310 403051
SGTC_2771 fluoxetine 41.05 µM 0.642899820565758 0.230061184818167 no 794 0.260144552932008 301 3386 A selective serotonin reuptake inhibitor.
SGTC_1175 0741-0056 27.6 µM 0.641348533432185 0.230628133567516 no 795 0.260648131605215 296 765927
SGTC_1023 4482-3888 16 µM 0.640498343083199 0.230939183408051 no 796 0.260924332998818 300 3303168
SGTC_2347 9049783 174.81 µM 0.640049333101926 0.231103552242862 no 797 0.261070263616218 317 6467988 YPL169C MEX67
SGTC_622 1348-1566 26.3 µM 0.639313731252278 0.231372974643408 no 798 0.261309428745145 295 7340407
SGTC_3305 9127027 53.8275 µM 0.637556350401551 0.232017343599874 no 799 0.261881258643425 294 41905295
SGTC_2216 7189485 200 µM 0.637212162482028 0.232143661953019 no 800 0.261993328220756 271 731273
SGTC_826 1683-5028 118 µM 0.636953653583528 0.232238560925644 no 801 0.262077516378437 294 722377
SGTC_992 3909-8734 162 µM 0.636604665940546 0.232366709005548 no 802 0.262191192586759 295 4288319
SGTC_365 0121-0052 13.6 µM 0.635344883157095 0.232829627704086 no 803 0.26260175339969 252 3101739
SGTC_1579 chlormadinone acetate 49.4 µM 0.635102665822216 0.232918691370698 no 804 0.26268072926036 313 45114258 A steroidal progestin.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.634795894257451 0.233031518878984 no 805 0.262780770705572 302 23847180
SGTC_1266 0828-0227 32.9 µM 0.634608235987644 0.233100552669543 no 806 0.262841977653125 303 3913820
SGTC_122 0236-0016 402.397 µM 0.633907249867623 0.233358524619219 no 807 0.263070676966541 308 6808838
SGTC_2085 5307070 144.047 µM 0.633378694430008 0.233553144554774 no 808 0.263243187353292 315 2840351
SGTC_1673 st016611 27.3 µM 0.631961408640093 0.234075448815219 no 809 0.26370604735003 308 5226799
SGTC_2335 9018011 154.17 µM 0.631349101148835 0.234301298959015 no 810 0.263906144274182 284 6458208
SGTC_1994 st072947 40.9 µM 0.630821857186363 0.234495869952354 no 811 0.264078505148805 310 5286565 YDL195W SEC31
SGTC_1132 3456-3614 2.5 µM 0.630494695091601 0.234616648844435 no 812 0.264185486259594 296 3125502
SGTC_340 k038-0059 454 µM 0.630391775227736 0.234654651028375 no 813 0.264219145337527 301 23733424
SGTC_2642 cholecalciferol 100 µM 0.630129163149484 0.234751633470342 no 814 0.264305040309281 291 9821465 A vitamin D precursor, similar to steriods.
SGTC_3065 9113888 49.47 µM 0.627128647057881 0.235861293391159 no 815 0.265287455159094 299 16648368
SGTC_2563 tomatine 8.54 µM 0.626604620080642 0.236055386792011 no 816 0.265459219553529 340 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_861 0443-0273 110 µM 0.624905760103377 0.236685229153309 no 817 0.26601645581519 303 6149169
SGTC_1403 3909-7815 62.9 µM 0.623282336222754 0.237287966764827 no 818 0.266549501649608 291 6615483
SGTC_2167 5876490 200 µM 0.621860311843199 0.237816621506857 no 819 0.267016862025633 297 686534
SGTC_2788 5282734 71.43 µM 0.621272748748697 0.238035243627281 no 820 0.267210090369292 311 743706
SGTC_1634 st006576 41 µM 0.620892423444887 0.238176814840343 no 821 0.267335203280955 292 3915356
SGTC_1800 st050079 29.0735 µM 0.620427053271766 0.238350105658129 no 822 0.267488332994928 300 3645560
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.619918431698449 0.238539581034389 no 823 0.267655745124501 308 689007
SGTC_282 k297-0036 65.7 µM 0.619819202335538 0.238576556281734 no 824 0.267688412495761 302 5061378
SGTC_2192 5915882 198.485 µM 0.619408832995194 0.238729503076043 no 825 0.267823531821356 295 2876149
SGTC_519 k048-0011 62.8 µM 0.618853269500878 0.238936649935184 no 826 0.268006512896559 290 6836379
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.618512975901699 0.239063579995267 no 827 0.268118623490797 327 5393153
SGTC_958 1222-0007 33 µM 0.61832399544072 0.239134085926732 no 828 0.268180893778107 307 7312461
SGTC_1846 st056244 14.8 µM 0.617597579374886 0.239405207234877 no 829 0.268420320313908 314 5393182
SGTC_525 k781-2675 26.7 µM 0.616512736273409 0.239810417149096 no 830 0.268778084313897 294 3651118 YDL195W SEC31
SGTC_3199 9111318 49.47 µM 0.614955296610066 0.240392804614255 no 831 0.269292121559467 287 8548020
SGTC_2172 5754775 163.918 µM 0.614724465035982 0.240479187053502 no 832 0.2693683500858 287 2263357
SGTC_3210 9128157 49.47 µM 0.614132986427352 0.240700608969425 no 833 0.269563726034861 307 17590849
SGTC_2071 5230951 39.92 µM 0.613925604632499 0.240778269274687 no 834 0.269632244754805 312 1799272
SGTC_2186 6124449 200 µM 0.613609844008729 0.240896541448431 no 835 0.269736588476023 288 3834182 YLR033W RSC58
SGTC_653 0203-0016 55.2 µM 0.613588638681583 0.240904485306774 no 836 0.269743596542804 305 295302
SGTC_2819 7996655 46.38 µM 0.613494362956937 0.240939804242201 no 837 0.269774754467262 287 6456960
SGTC_3060 1327-0027 12.5 µM 0.612457692662173 0.241328362358682 no 838 0.270117490596908 272 16000455 YPR107C YTH1
SGTC_172 1112-0046 2.638 µM 0.612384217497483 0.241355914764032 no 839 0.270141790666332 295 2802135 YIL048W NEO1
SGTC_1472 k841-0093 193 µM 0.611497261594781 0.241688648594895 no 840 0.270435215345887 312 X1472
SGTC_669 0108-0021 26.2 µM 0.611387882686051 0.241729698385457 no 841 0.270471411343081 338 17201
SGTC_2325 6158266 200 µM 0.610440344033828 0.242085466991008 no 842 0.270785074965786 287 3623240
SGTC_2411 st077133 39.94 µM 0.610387785679005 0.242105209177249 no 843 0.270802478666602 301 1403142 YNL221C POP1
SGTC_409 arachidonic acid 100 µM 0.610180668778208 0.242183015780221 no 844 0.270871066929046 300 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2162 5663267 200 µM 0.609042777601975 0.242610723557506 no 845 0.271248042425529 325 6456493
SGTC_2403 6032726 181.2 µM 0.608932987616443 0.242652012775874 no 846 0.271284428919621 291 2881040
SGTC_2820 7989630 71.43 µM 0.607420530486185 0.24322119641395 no 847 0.271785933513423 261 2984098
SGTC_2457 5731572 11.68 µM 0.606469042054193 0.243579639979018 no 848 0.272101666849827 325 2865357
SGTC_346 4513-0042 7.16 µM 0.603746839364161 0.244606718672748 no 849 0.273005983978757 296 2827372
SGTC_1912 st060209 90.8 µM 0.603720257597061 0.24461675937768 no 850 0.273014821795765 321 688787
SGTC_904 1141-0088 396 µM 0.603617664214559 0.244655513957355 no 851 0.273048933030417 307 1378119
SGTC_1938 st074717 56.4 µM 0.603248380579703 0.244795037961455 no 852 0.273171733490688 279 17250979
SGTC_3111 9122088 49.47 µM 0.602956083768194 0.244905504901839 no 853 0.273268952384862 289 16876704
SGTC_2900 5328528 85.29 µM 0.602853768736753 0.244944178881349 no 854 0.273302986754595 296 795359
SGTC_1251 0490-5699 265 µM 0.602833494242563 0.244951842811789 no 855 0.273309731170553 300 3883818
SGTC_2350 9023895 38.85 µM 0.601953551427644 0.245284592930684 no 856 0.273602528127876 309 2997209
SGTC_3181 9108277 49.47 µM 0.601676439675661 0.245389432947774 no 857 0.273694767925497 323 17097298
SGTC_3068 9116768 49.47 µM 0.601098294517654 0.245608240801227 no 858 0.273887259628365 306 41904888
SGTC_575 k072-0246 11.9 µM 0.600808397883324 0.245717996037713 no 859 0.273983805034589 292 6796779
SGTC_3257 9139206 32.98 µM 0.600787969146344 0.245725731376824 no 860 0.273990609130858 298 4910041
SGTC_2532 xanthone 78.9 µM 0.598463801723144 0.246606630122078 no 861 0.274765252595399 291 7020 An insecticide.
SGTC_2738 aclarubicin 5.55 µM 0.598120108860784 0.246737038938827 no 862 0.274879896775801 259 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_367 0335-0881 7.1 µM 0.597050642437176 0.247143067151103 no 863 0.275236784926425 318 23828853
SGTC_568 1193-0097 7.48 µM 0.595594351261873 0.247696529405586 no 864 0.275723125594534 290 3646150
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.594991123884807 0.247925979192404 no 865 0.275924702089577 349 6728940
SGTC_397 arbidol 50 µM 0.592863743132845 0.248736076290994 no 866 0.276636172091356 296 131410 A RNA synthesis inhibitor.
SGTC_2193 5925765 200 µM 0.591999005070182 0.249065767150664 no 867 0.276925627316809 289 877370
SGTC_2505 galangin 7.89 µM 0.591255770262277 0.249349319237098 no 868 0.277174530000246 328 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1783 st039459 87.517 µM 0.591217993316873 0.249363736130188 no 869 0.277187184083477 351 729761
SGTC_2551 apiole 73.87 µM 0.591139678423872 0.249393625014671 no 870 0.277213417998702 299 10659 A possible DNA adduct former.
SGTC_3032 9089427 49.47 µM 0.590478756272381 0.249645941827502 no 871 0.277434862001475 295 17173707
SGTC_1805 st050013 60.3 µM 0.590241151654241 0.249736684030571 no 872 0.277514493287134 303 4037144
SGTC_3 0833-0587 95.581 µM 0.589432058735059 0.250045811339876 no 873 0.277785738052342 308 5382644
SGTC_2943 9068529 45.32 µM 0.589306868693026 0.250093660392459 no 874 0.277827719013218 329 3270634
SGTC_3014 9081533 49.47 µM 0.588956662480059 0.250227538970862 no 875 0.27794517286501 340 21367265
SGTC_1196 1588-0294 184 µM 0.588724737852433 0.25031622118855 no 876 0.278022970203286 325 6144269
SGTC_3089 9117425 49.47 µM 0.588390518922365 0.250444047508857 no 877 0.27813510006512 330 9401657
SGTC_154 3389-1638 511.116 µM 0.588187293664016 0.25052179052766 no 878 0.27820329256306 340 5238686
SGTC_1612 st002233 45.4 µM 0.583739755603065 0.252226375781147 no 879 0.279697707819993 293 1035021
SGTC_2966 9084041 48.03 µM 0.582816250040679 0.252581088332675 no 880 0.280008502236007 302 17741380
SGTC_807 1315-0151 48 µM 0.582688727884779 0.252630089414128 no 881 0.28005143139775 332 4011080
SGTC_2426 5582046 32.21 µM 0.581464862831529 0.253100620726176 no 882 0.280463596471714 306 2251934
SGTC_161 4065-0411 162.148 µM 0.580458946487825 0.253487703626027 no 883 0.280802581947231 314 1906281 YLR208W SEC13
SGTC_2068 5226020 147 µM 0.578604763840761 0.254202019013363 no 884 0.281427944797992 316 1810509
SGTC_2932 9016711 44.54 µM 0.577841783687239 0.254496259871626 no 885 0.281685471237702 324 7117328
SGTC_2584 androsterone 48.74 µM 0.577685137828556 0.254556691918455 no 886 0.281738357506605 290 2754130 A steroid.
SGTC_87 0100-0052 35.5 µM 0.577660368965252 0.25456624812972 no 887 0.281746720328474 322 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_558 k064-0027 21.3 µM 0.574789984147594 0.255674958600511 no 888 0.282716670686611 314 5088526
SGTC_1687 st020778 55.3625 µM 0.574108594289004 0.255938521055503 no 889 0.282947158982205 298 4259299
SGTC_492 tmb-8 126 µM 0.573938697225562 0.256004259527474 no 890 0.283004642751655 327 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_594 1487-1584 10.8 µM 0.573349543406023 0.256232289730845 no 891 0.283204023234232 326 5013332
SGTC_2348 9022543 33.42 µM 0.573031159043475 0.25635556349608 no 892 0.283311798395261 315 3162678 YDL140C RPO21
SGTC_1590 st077108 57.8 µM 0.57263835693595 0.256507693302163 no 893 0.283444791538773 286 5489485
SGTC_935 2996-0153 430 µM 0.572584356719246 0.256528610925759 no 894 0.28346307702501 318 23738523
SGTC_411 enrofloxacin 100 µM 0.571980400494333 0.256762621052987 no 895 0.283667626446495 306 71188 A bacterial gyrase inhibitor.
SGTC_1226 3909-7979 35.4 µM 0.571075472219786 0.257113454304306 no 896 0.283974242105655 313 6615510
SGTC_3259 9138485 49.47 µM 0.570995384676984 0.257144515589149 no 897 0.28400138569932 291 17646153
SGTC_426 0988-0037 14.6 µM 0.570927777395025 0.257170738027744 no 898 0.284024300398763 314 5383008
SGTC_2906 7926292 26.41 µM 0.570624038803399 0.25728856448043 no 899 0.284127259963016 331 2966319
SGTC_1722 st034304 3.6505 µM 0.570587679037047 0.257302671062574 no 900 0.284139586184078 329 4036148 YLR033W RSC58
SGTC_2582 agaric acid 100 µM 0.569234828336056 0.257827825251486 no 901 0.284598393931876 294 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2894 9048625 32.47 µM 0.567078806362309 0.258665905355813 no 902 0.2853303206338 342 4092861
SGTC_450 aminopyrene 156 nM 0.567061882810179 0.258672489384347 no 903 0.28533606938902 318 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_701 4424-0219 185 µM 0.56685108730342 0.258754505656782 no 904 0.285407679060316 316 2911779
SGTC_2327 6189656 200 µM 0.566681166114613 0.258820628354004 no 905 0.285465409482325 339 5349088
SGTC_2305 7443522 69.23 µM 0.565204102609935 0.259395777198973 no 906 0.285967473255409 310 5415886
SGTC_2043 5101342 149 µM 0.564415568125668 0.259703092122257 no 907 0.286235673132761 328 678451
SGTC_2737 bleomycin 30.5 nM 0.564082740062412 0.259832861315648 no 908 0.28634891194143 308 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_294 k038-0071 157 µM 0.562701131940363 0.260371905837348 no 909 0.286819206670488 320 24152826
SGTC_1837 st055472 66.5 µM 0.560562571775371 0.261207415208378 no 910 0.287547886343416 292 676091
SGTC_117 lucigenin 22.078 µM 0.560347409034317 0.261291552880528 no 911 0.287621247987895 334 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1002 4049-0206 172 µM 0.558995756681503 0.261820424013714 no 912 0.288082308068977 321 4662749
SGTC_855 0428-0020 25 µM 0.558707301718038 0.261933360996604 no 913 0.288180747644797 303 6812414
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.55824287388746 0.262115248015903 no 914 0.28833927393127 275 4000243
SGTC_3107 9121808 49.47 µM 0.558074429219267 0.262181233134912 no 915 0.288396780446114 270 662681
SGTC_427 1354-0053 47.3 µM 0.557189637363517 0.262527973883039 no 916 0.288698934538866 331 6813657
SGTC_2799 7812892 81.82 µM 0.5559792530039 0.263002690840873 no 917 0.289112518913305 325 20205235
SGTC_1716 st033144 30.6155 µM 0.555751012254753 0.263092256800849 no 918 0.28919053924314 344 674617
SGTC_2104 5389443 200 µM 0.554375578889359 0.263632332484549 no 919 0.289660917849788 331 2244536
SGTC_1830 st055982 50.3 µM 0.552195526027413 0.264489506098928 no 920 0.290407199653769 353 455313 An antimicrobial agent.
SGTC_2246 7293507 91.5585 µM 0.552149085860973 0.264507781294339 no 921 0.290423106968983 316 887656
SGTC_3253 9135987 49.47 µM 0.551931957891107 0.264593234302817 no 922 0.290497485995403 310 4182430
SGTC_1405 3909-7894 12 µM 0.551849641132948 0.264625634604416 no 923 0.290525686629097 320 7104060
SGTC_2429 5902844 64.44 µM 0.551654411490032 0.264702486069454 no 924 0.2905925748471 325 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.551430460221892 0.264790657677163 no 925 0.290669312339776 330 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1694 st024011 44.9 µM 0.55049825820462 0.265157834274919 no 926 0.290988835617197 350 2787533
SGTC_3186 9110464 49.47 µM 0.550285969524162 0.265241486870176 no 927 0.291061623010745 330 17018021
SGTC_1665 st014639 11.4 µM 0.550091505008049 0.265318127590434 no 928 0.291128306497833 315 981133 YIL048W NEO1
SGTC_3284 9108171 64.8615 µM 0.549447461581236 0.265572032808834 no 929 0.291349205229583 321 8687505
SGTC_1171 0368-0077 21.4 µM 0.549080976092188 0.265716569646197 no 930 0.291474940013507 339 3239779
SGTC_101 0490-5701 117.494 µM 0.548282291173416 0.266031698100723 no 931 0.291749042535483 333 4661669
SGTC_3208 9114115 49.47 µM 0.546834842710795 0.266603284149961 no 932 0.292246101578547 337 650895
SGTC_2065 5221596 34.26 µM 0.546152480314756 0.266872958918439 no 933 0.292480563849002 298 788581
SGTC_1773 st048542 73.5835 µM 0.546052832042802 0.266912352196863 no 934 0.292514810682791 324 3237138
SGTC_2415 st077333 57.7 µM 0.545938172795488 0.266957683297056 no 935 0.292554218751505 347 2766255
SGTC_3011 9081274 71.4286 µM 0.545544387738024 0.267113397771121 no 936 0.292689580377853 321 6625322
SGTC_1981 st071826 47 µM 0.545475554410652 0.267140621249749 no 937 0.292713244473303 308 11838600
SGTC_530 4358-1714 28 µM 0.54518541236271 0.267255387390854 no 938 0.292813001691879 317 1564641
SGTC_2375 9072683 200 µM 0.544545664165672 0.267508528674187 no 939 0.293033016946738 321 16798029
SGTC_1772 st048439 82.2 µM 0.544148211449543 0.267665857183648 no 940 0.293169743181707 293 2927068 YDL195W SEC31
SGTC_2882 9058044 58.44 µM 0.543928533554661 0.267752834945222 no 941 0.293245326450719 301 18076804
SGTC_745 0469-0705 296 µM 0.540930766396758 0.2689411716931 no 942 0.294277651895477 354 3486736
SGTC_978 1416-0512 87.4 µM 0.539662203000283 0.269444835581275 no 943 0.294715005323906 333 6814003
SGTC_3044 9093193 49.47 µM 0.539045491375352 0.269689862283864 no 944 0.294927732759541 329 25236277
SGTC_159 3970-0959 50 µM 0.538632593349251 0.269853973826317 no 945 0.295070196620078 325 6615653
SGTC_51 1013-0126 23.419 µM 0.536145795509853 0.270843439203829 no 946 0.295928895972857 342 1627850
SGTC_1423 4048-0112 5.59 µM 0.534336881620682 0.271564319028647 no 947 0.296554239790792 328 X1423
SGTC_2289 7946404 165.07 µM 0.533138820055013 0.272042290287796 no 948 0.296968744172276 334 1246120 YPR165W RHO1
SGTC_102 gallobenzophenone 83.616 µM 0.532815270229856 0.272171443435606 no 949 0.297080731119232 326 70837
SGTC_2493 resveratrol 26.09 µM 0.532770852359091 0.272189176338174 no 950 0.297096106523801 304 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2115 tiliquinol 12.7705 µM 0.532481049365358 0.272304888194235 no 951 0.297196431795336 349 71208 A bioactive hydroxyquinoline.
SGTC_2681 menadione 3.18 µM 0.53185129168592 0.272556420586367 no 952 0.297414497441795 333 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2977 9011197 71.43 µM 0.530496616547436 0.273097883907813 no 953 0.297883827130047 366 2704722
SGTC_2215 7188065 200 µM 0.530289321013568 0.273180786889143 no 954 0.297955674829249 335 940217
SGTC_1236 0330-0013 258 µM 0.53019006946813 0.273220484628235 no 955 0.297990077764572 341 4617066
SGTC_2212 7123476 200 µM 0.529335772937362 0.273562296582199 no 956 0.298286271996426 313 1085715
SGTC_2657 nystatin 74.44 µM 0.528226136588808 0.274006588088324 no 957 0.298671195417226 321 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2662 daunorubicin 22.37 µM 0.527696297290274 0.274218858170972 no 958 0.29885507179747 305 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3027 9089541 49.47 µM 0.527422148795671 0.274328722447478 no 959 0.298950232970123 318 9943819
SGTC_2390 9097792 176.6 µM 0.527088156202842 0.274462598443835 no 960 0.299066185546258 311 4497149
SGTC_1258 0671-0043 57.1 µM 0.524163502628236 0.275636278022248 no 961 0.300082411774767 347 4298767
SGTC_52 0329-0193 875 nM 0.52406150579174 0.275677254401672 no 962 0.300117880676535 365 3739292
SGTC_2946 9065502 71.43 µM 0.523334191283576 0.275969533727382 no 963 0.300370855691167 306 16489101
SGTC_1220 1838-0075 193 µM 0.522930184567901 0.276131953988748 no 964 0.300511419187744 311 5529645
SGTC_2864 9034755 47.6 µM 0.522451567187357 0.276324430206126 no 965 0.300677979932157 309 4930451
SGTC_3290 9121031 71.43 µM 0.521892247100461 0.276549444425741 no 966 0.300872678318132 323 17014854
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.52019589624694 0.277232434448423 no 967 0.301463522649064 313 6708630 An antioxidant.
SGTC_3042 9091578 49.47 µM 0.518320364018532 0.277988526173488 no 968 0.302117383531059 316 25236497
SGTC_3201 9113999 49.47 µM 0.516743734999897 0.278624897191049 no 969 0.30266753079451 346 16649224
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.516464484806255 0.278737684190137 no 970 0.302765018833419 361 7104
SGTC_1008 4106-0037 6 µM 0.515081811907586 0.279296462335553 no 971 0.30324792589978 349 2905394
SGTC_812 4251-0442 148 µM 0.51385682006223 0.279791971300062 no 972 0.303676049332573 365 5723007
SGTC_2602 kawain 100 µM 0.513773948788929 0.279825508109595 no 973 0.303705021824388 313 5369129
SGTC_2705 st078069 42.8 µM 0.511768031859199 0.280637868039483 no 974 0.3044066831572 331 1530061
SGTC_50 0929-0078 56.389 µM 0.511657716473111 0.280682576845603 no 975 0.304445291942277 336 1377751
SGTC_403 arphamenine a 50 µM 0.511549874101045 0.280726286714538 no 976 0.304483037314869 346 5487158 An arginine aminopeptidase inhibitor.
SGTC_2179 6298986 200 µM 0.510693811997539 0.281073376186923 no 977 0.30478273720249 329 738374
SGTC_2133 5320837 200 µM 0.510419404008645 0.281184678477808 no 978 0.304878832794771 345 2841355
SGTC_1426 4048-4480 71.7 µM 0.509937881152698 0.281380039808241 no 979 0.305047490969907 328 14224343
SGTC_2829 7992743 58.44 µM 0.509170459440031 0.281691530091369 no 980 0.305316373661462 311 16462845
SGTC_2407 paclitaxel 400 µM 0.509146017897074 0.281701453447605 no 981 0.305324939008727 383 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2309 7664088 163.95 µM 0.507506326192663 0.282367558913168 no 982 0.305899799365292 355 704922
SGTC_1502 4534-4282 27.7 µM 0.50677952730355 0.282663054574314 no 983 0.306154761306647 363 3278949
SGTC_2237 6667747 47.222 µM 0.505967048723188 0.28299356097199 no 984 0.306439890972344 372 729940 YDL015C TSC13
SGTC_1606 st000094 49.2 µM 0.504619033437127 0.283542326073188 no 985 0.306913219407185 337 1242210
SGTC_1427 4048-4900 550 nM 0.504576499281402 0.283559649647144 no 986 0.306928159664923 346 24132586
SGTC_591 4299-0174 154 µM 0.502217366577471 0.284521285046606 no 987 0.307757314067807 354 5509088
SGTC_2200 6600604 21.907 µM 0.50126806936526 0.284908678892613 no 988 0.308091237090484 365 2904777
SGTC_453 enantio-paf c16 10 µM 0.499949375952438 0.2854472348843 no 989 0.308555361923396 371 13871343 A lipid and platelet activating factor
SGTC_2362 9071156 126 µM 0.499939465545661 0.28545128414093 no 990 0.308558851130953 334 653133
SGTC_1028 k015-0029 4.8 µM 0.499090895544042 0.285798099622717 no 991 0.308857675593195 341 4588309
SGTC_2572 astragaloside iv 100 µM 0.498206244244224 0.2861598749614 no 992 0.30916934087588 324 45006101 An anti-inflammatory agent.
SGTC_376 3970-0862 59.1 µM 0.496387380224932 0.286904376257451 no 993 0.309810563512274 350 3135186
SGTC_3100 9120536 49.47 µM 0.496161232775554 0.286997007523751 no 994 0.309890330089818 342 16421196
SGTC_2184 6075246 200 µM 0.495454805279358 0.287286455399928 no 995 0.310139558360985 334 2267320
SGTC_3153 9100258 49.47 µM 0.494317767523557 0.287752629140364 no 996 0.310540889515242 368 25236848
SGTC_3230 9131665 49.47 µM 0.493859642411613 0.287940556659316 no 997 0.31070265407657 348 15943720
SGTC_2531 methyl deoxycholate 70.07 µM 0.492834618318732 0.288361241573926 no 998 0.311064723921387 351 16667744 Haematoxylin.
SGTC_632 0781-2353 4.65 µM 0.492812713253904 0.288370234895283 no 999 0.311072463457598 348 6811515 YHR007C ERG11
SGTC_1434 4073-0095 163 µM 0.492695075697622 0.288418534313708 no 1000 0.311114028795927 347 24133745
SGTC_1453 4237-0541 195 µM 0.492102320319673 0.288661964759757 no 1001 0.311323506019325 320 739892
SGTC_2140 5586273 200 µM 0.491525760292429 0.288898836961233 no 1002 0.311527318506178 342 854421
SGTC_2139 5578692 56.4705 µM 0.491269175187265 0.289004281024493 no 1003 0.311618039258493 334 650991 YMR113W FOL3
SGTC_2061 5245884 80.95 µM 0.491175109490218 0.289042942009422 no 1004 0.311651300916182 365 573863
SGTC_1367 1812-0510 76.9 µM 0.49101197332559 0.289109996711632 no 1005 0.311708989554851 326 1142582 YDR527W RBA50
SGTC_1032 k061-1018 98.7 µM 0.489568528836265 0.289703621650193 no 1006 0.312219625386771 343 4005393
SGTC_697 0508-1955 564 µM 0.489392861262131 0.289775904987844 no 1007 0.312281794556672 345 6243113
SGTC_894 0960-0238 55.9 µM 0.489198730931358 0.289855795184541 no 1008 0.312350503956845 346 6741907 YDL195W SEC31
SGTC_2953 9074162 66.49 µM 0.487667146842195 0.290486447932204 no 1009 0.312892812905847 347 16451992
SGTC_1509 1326-1131 80 µM 0.487080266068299 0.290728274981186 no 1010 0.313100725252232 330 768313
SGTC_324 1315-0088 19.6 µM 0.486797568983724 0.290844795263786 no 1011 0.313200896646486 369 6787421
SGTC_2057 5236571 38.335 µM 0.486335078262808 0.291035468798587 no 1012 0.313364806165168 348 54684039 YBR257W POP4
SGTC_2522 biochanin a 4.94 µM 0.484967614982601 0.291599581541079 no 1013 0.313849659030367 355 5280373 A possible chelator.
SGTC_559 1550-0661 158 µM 0.484081961328404 0.291965207576469 no 1014 0.314163851346854 356 5830875
SGTC_381 3461-2219 42.7 µM 0.482861836006729 0.292469263498121 no 1015 0.31459692063586 371 2883159
SGTC_3155 9099265 49.47 µM 0.482635333094996 0.292562880459884 no 1016 0.31467734331115 370 25236499
SGTC_577 r071-0003 38.6 µM 0.482600018083924 0.292577477924436 no 1017 0.314689883137316 356 4568517 YMR134W ERG29
SGTC_2589 lobaric acid 100 µM 0.481045767226931 0.293220262658156 no 1018 0.315241985618907 338 73157 A novel microtubule depolymerizer.
SGTC_2338 7999974 200 µM 0.479928297907293 0.293682813743108 no 1019 0.315639189381212 356 315925
SGTC_1295 1013-0063 9.78 µM 0.47870522231807 0.294189464909004 no 1020 0.316074175048027 354 6826038
SGTC_919 tnp00227 403.569 nM 0.477960160022499 0.294498299951455 no 1021 0.316339280638261 377 1269246 A methoxyflavone. YNL221C POP1
SGTC_1061 3448-9325 110 µM 0.477292915703577 0.294775005676848 no 1022 0.316576777443491 365 723482
SGTC_739 1486-1183 203 µM 0.47705571599802 0.29487340109218 no 1023 0.316661223777062 352 4346692
SGTC_810 3825-7150 143 µM 0.475995679843948 0.295313311210828 no 1024 0.317038727848673 323 22330411 YGL099W LSG1
SGTC_2448 5185112 27.17 µM 0.474539849969836 0.295917965611315 no 1025 0.317557493919763 327 5718189
SGTC_1596 piperlongumine 63 µM 0.474253072187149 0.296037140920056 no 1026 0.317659725752327 325 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2650 prasterone 100 µM 0.47420372476085 0.296057650290569 no 1027 0.31767731874699 332 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1715 st032160 10.2275 µM 0.473711251829758 0.296262363549295 no 1028 0.317852914255947 347 5289825
SGTC_1411 3909-8223 150 µM 0.473110979814732 0.296511974946337 no 1029 0.318067001865935 359 X1411
SGTC_572 0960-0087 17.7 µM 0.473065802000676 0.296530765156899 no 1030 0.318083117039422 355 6796365
SGTC_1062 mesoridazine 14.2 µM 0.472364517566735 0.296822511053563 no 1031 0.318333313186621 341 4078 A neuroleptic.
SGTC_1384 3089-0840 101 µM 0.471693921674495 0.297101612829135 no 1032 0.318572638164561 324 1069836
SGTC_1386 3228-0095 33.8 µM 0.468973041209939 0.298235271539234 no 1033 0.319544452955301 364 870181
SGTC_1618 st003135 44.5 µM 0.468971998650597 0.298235706300383 no 1034 0.319544825563599 369 1270615
SGTC_2476 5806916 10.51 µM 0.46879095087712 0.298311210012804 no 1035 0.319609534381765 350 2870194
SGTC_27 0485-0001 32.618 µM 0.468662284899627 0.2983648738408 no 1036 0.319655524606567 351 2054479
SGTC_327 1273-0057 3.96 µM 0.468058497901578 0.298616759157568 no 1037 0.319871378597308 346 3108138
SGTC_2884 9058502 51.95 µM 0.466889826556458 0.299104575066283 no 1038 0.320289352148638 344 6471554
SGTC_2851 9015922 71.43 µM 0.465727322664644 0.299590175184701 no 1039 0.320705346243287 367 2996893
SGTC_607 4491-0986 66.8 µM 0.464970643771685 0.299906446256742 no 1040 0.32097623969861 337 698981 YDR232W HEM1
SGTC_602 3130-1533 38.1 µM 0.463398375706146 0.300564094027252 no 1041 0.321539421358417 370 720941
SGTC_863 0466-0191 129 µM 0.463354139848994 0.300582606401788 no 1042 0.321555272450461 373 765160 YPR165W RHO1
SGTC_2004 4023728 41.89 µM 0.461976892340478 0.301159231484634 no 1043 0.322048945740456 373 360084 YDR527W RBA50
SGTC_1248 0469-0687 58.6 µM 0.460791974033796 0.301655730772263 no 1044 0.322473930256251 353 4017482
SGTC_81 0411-0046 9.971 µM 0.459325077499823 0.302270892742896 no 1045 0.323000370969183 340 12925265
SGTC_218 alverine citrate 93.75 µM 0.459137578923405 0.30234956324405 no 1046 0.323067686165591 370 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_168 3970-0862 530.542 µM 0.458861999790946 0.302465207180262 no 1047 0.323166634306184 365 3135186
SGTC_443 clozapine 122 µM 0.458763845034229 0.30250640159938 no 1048 0.323201880311585 375 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2468 5987765 72.9 µM 0.458505520566207 0.302614829417195 no 1049 0.323294648612941 349 26772094
SGTC_1899 st063254 59.6 µM 0.458165526992918 0.302757563154889 no 1050 0.323416762297582 343 3093813
SGTC_164 4100-3994 89.624 µM 0.457902352034355 0.302868068134952 no 1051 0.323511298511043 387 4615967
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.456185988100774 0.303589197551962 no 1052 0.324128120223287 337 2333 A French combination drug.
SGTC_754 3474-0146 171 µM 0.45615868953532 0.303600673221595 no 1053 0.324137934606836 323 24762078
SGTC_1796 st049173 110.4 µM 0.456131727980004 0.303612007410256 no 1054 0.32414762794842 373 94134
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.455879318019384 0.303718125513903 no 1055 0.324238381312273 392 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_485 niflumic acid 177 µM 0.45564419170994 0.303816992119934 no 1056 0.324322929778361 362 4488 A COX2 inhibitor.
SGTC_1978 st071761 42 µM 0.455617137255588 0.30382836897792 no 1057 0.324332658801345 337 5147680
SGTC_3263 9137018 49.47 µM 0.455528285363713 0.303865734045878 no 1058 0.324364611577452 345 43844957
SGTC_2985 9022375 71.43 µM 0.453861332939247 0.304567120526163 no 1059 0.324964317875999 344 4939335
SGTC_3033 9090887 49.47 µM 0.453515824166437 0.304712586773075 no 1060 0.325088675668507 343 19325384
SGTC_773 4358-1457 44.6 µM 0.453365639658701 0.304775827147484 no 1061 0.325142737142543 380 1186886
SGTC_2245 6637752 200 µM 0.453211700513118 0.304840654595985 no 1062 0.325198153982758 373 681890
SGTC_1798 st045719 60.953 µM 0.450488344092992 0.305988536513676 no 1063 0.326179178426169 388 3980186
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.450485539123828 0.305989719780438 no 1064 0.326180189471493 334 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2283 7944793 200 µM 0.449440291429261 0.306430794852449 no 1065 0.3265570357227 360 2970533
SGTC_3224 9130643 49.47 µM 0.449156076265844 0.306550776910476 no 1066 0.326659535292766 341 17644395
SGTC_2896 9052656 71.43 µM 0.448049708649329 0.307018029832114 no 1067 0.327058661094268 354 6469436
SGTC_1201 1889-3372 45.9 µM 0.445967821478218 0.3078981243996 no 1068 0.327810245079257 343 5392199
SGTC_2226 7298446 200 µM 0.445871600547191 0.307938827506273 no 1069 0.327844998784235 382 3283010
SGTC_2497 7-hydroxyflavone 100 µM 0.445010234384027 0.3083033054028 no 1070 0.328156179034513 392 5281894
SGTC_3101 9120531 49.47 µM 0.442378997721101 0.309417854816785 no 1071 0.329107487156212 394 24824904
SGTC_2812 7970281 58.44 µM 0.44033201239855 0.310286139605869 no 1072 0.329848329173632 369 2233435
SGTC_2594 a-mangostin 100 µM 0.44019387606118 0.310344772089418 no 1073 0.329898347370948 390 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_858 0438-0351 2.77 µM 0.440184076342857 0.310348931799532 no 1074 0.329901895895657 337 2799119
SGTC_3195 9113082 49.47 µM 0.439351735970805 0.310702325817214 no 1075 0.330203346146198 356 17018038
SGTC_994 3910-0338 138 µM 0.438215743056969 0.311184926181332 no 1076 0.330614948696409 358 3479481
SGTC_751 0833-0568 350 µM 0.437827272016738 0.311350033697498 no 1077 0.330755749854067 377 6954252
SGTC_2991 9074669 71.4286 µM 0.437656800525298 0.311422499279641 no 1078 0.330817544733117 388 17333109
SGTC_2793 7325131 81.82 µM 0.43751702889704 0.311481920134541 no 1079 0.330868214538376 363 4176441
SGTC_1889 st059080 5.18 µM 0.435982437042062 0.312134641009107 no 1080 0.331424736122197 346 176925 Isolated from Daphnopsis sellowiana.
SGTC_526 4469-0568 170 µM 0.43586414960369 0.312184977726104 no 1081 0.331467648679251 365 2901964
SGTC_1878 temozolomide 1 mM 0.43550772554969 0.312336673665791 no 1082 0.33159696629674 375 5394 DNA alkylating agent.
SGTC_507 nimesulide 162 µM 0.434866793943982 0.312609537534517 no 1083 0.331829559316327 370 4495 A COX2 inhibitor.
SGTC_2739 tacrine 100.86 µM 0.432992027781112 0.313408271296019 no 1084 0.332510280771073 355 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3271 9137798 49.47 µM 0.432540502669084 0.31360077209547 no 1085 0.332674310736992 347 6498326
SGTC_2087 5276107 200 µM 0.432524856281227 0.313607443603149 no 1086 0.332679995328611 364 144405
SGTC_2651 TUB2.036 5 µM 0.431523434453413 0.314034569437453 no 1087 0.333043908427084 357 15992207 YFL037W TUB2
SGTC_2765 myclobutanil 7.74 µM 0.429674823637594 0.314823692234226 no 1088 0.333716099927961 382 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1420 4'-methoxyflavone 42 µM 0.428988398348617 0.315116924594394 no 1089 0.333965833846468 371 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2137 5261020 140 µM 0.42829226864705 0.315414421591806 no 1090 0.334219173521764 357 763655
SGTC_416 estradiol valerate 100 µM 0.427497778405921 0.315754100075264 no 1091 0.334508401454718 367 13791 A steroid.
SGTC_783 0848-0141 92.7 µM 0.425175064148426 0.316748051581749 no 1092 0.335354530285448 384 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1098 clofazimine 15.1 µM 0.424869306813862 0.316878992113265 no 1093 0.335465975296806 371 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_298 1391-0729 10 µM 0.424703618447989 0.316949957715603 no 1094 0.335526372838665 366 3237558
SGTC_3116 9124943 49.47 µM 0.424572079800332 0.317006301526421 no 1095 0.335574324983055 330 41905195 YPL160W CDC60
SGTC_873 0591-4978 488 µM 0.423896374783905 0.317295802684109 no 1096 0.335820694060393 401 3305145
SGTC_891 0929-0073 133 µM 0.42385120851209 0.317315157850962 no 1097 0.335837164670394 405 5603632
SGTC_1609 st001574 46.4 µM 0.423814258027699 0.317330992666275 no 1098 0.335850639495406 409 3960012
SGTC_1983 st071813 46.9 µM 0.423272030175817 0.317563398233614 no 1099 0.336048399335031 369 11838595
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.423037874695816 0.317663782410515 no 1100 0.336133813909477 375 140250 A respiratory chain inhibitor.
SGTC_1561 5-methoxyflavone 52.9 µM 0.421643852213131 0.318261687384207 no 1101 0.336642496494603 373 94525
SGTC_479 n-linoleoylglycine 10 µM 0.421201094076705 0.318451688337449 no 1102 0.336804122759495 369 6433346 An anti-infammatory.
SGTC_1556 plumbagin 1.48 µM 0.4204674312816 0.318766630426671 no 1103 0.337072008413649 374 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3303 9125618 40.5795 µM 0.420166250875645 0.318895957154501 no 1104 0.337182003729397 376 22695467
SGTC_3061 glucosamine 200 µM 0.419269384130834 0.319281201891895 no 1105 0.337509634478902 367 91431 and experimental redox chemotherapeutic
SGTC_2123 5259487 200 µM 0.419063257017122 0.319369770390766 no 1106 0.337584951360323 381 2173474
SGTC_1629 st005085 44.9 µM 0.417766929209014 0.319927011348972 no 1107 0.338058766193111 376 24207091
SGTC_1103 duloxetine 36.1 µM 0.417356464712085 0.320103538897616 no 1108 0.338208846722613 369 60835 A selective serotonin reuptake inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM 0.416646026022712 0.320409171921846 no 1109 0.338468669320338 360 5282280 An endocannabinoid.
SGTC_3209 9113616 49.47 µM 0.416408636525533 0.320511324821459 no 1110 0.338555504878686 399 16649353
SGTC_3122 9126309 49.47 µM 0.41636953310732 0.320528153018648 no 1111 0.338569809482311 428 17591206
SGTC_1743 st037606 46.3785 µM 0.415977899770948 0.320696713184024 no 1112 0.338713087542069 330 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1653 st012112 65 µM 0.415025444090275 0.321106807239459 no 1113 0.339061638413564 373 720429
SGTC_44 0929-0055 61.211 µM 0.413984782603382 0.3215551291671 no 1114 0.339442625705459 347 1379590
SGTC_2382 9035899 200 µM 0.413755113844442 0.321654106611041 no 1115 0.3395267298116 389 6462679
SGTC_1738 st035555 74 µM 0.413398532677132 0.321807802977131 no 1116 0.339657324750089 399 5331140
SGTC_468 gf-109203x 121 µM 0.413066848730931 0.321950795327213 no 1117 0.339778818568097 368 2396 A protein kinase C inhibitor.
SGTC_1462 k081-0014 26.5 µM 0.411086880972177 0.322804927608722 no 1118 0.340504414650747 344 3270634
SGTC_389 tpck 16.7 µM 0.408302629959079 0.324007599492766 no 1119 0.341525754356842 349 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1516 st013856 110 µM 0.407699984241859 0.324268158055416 no 1120 0.341746974518297 381 5281404 A mutagen and neurotoxin.
SGTC_743 1275-0778 158 µM 0.407411539639703 0.324392899791018 no 1121 0.341852876467829 392 2849257 YMR203W TOM40
SGTC_3126 9127922 49.47 µM 0.407130565766608 0.324514429659757 no 1122 0.341956047518358 409 45595682
SGTC_2295 7971645 200 µM 0.406931999951717 0.324600326773097 no 1123 0.34202896619774 394 2978226 YKL099C UTP11
SGTC_637 1181-0519 7.26 µM 0.405711862377231 0.325128347858101 no 1124 0.342477162609962 383 6252091 YGR060W ERG25
SGTC_2828 7998861 71.43 µM 0.405306608017963 0.3253038016424 no 1125 0.342626074904996 348 2988188
SGTC_1985 st071382 65.5 µM 0.404097367025026 0.325827569364232 no 1126 0.343070560536653 372 6123237
SGTC_402 epigallocatechin gallate 10 µM 0.402251038467349 0.326627946915218 no 1127 0.343749641942908 384 65064 An antioxidant.
SGTC_1701 st028638 40.4 µM 0.401620453894693 0.326901486467522 no 1128 0.343981687231749 368 3490878
SGTC_1930 st074634 34.3 µM 0.401388990146377 0.327001915844112 no 1129 0.344066877031935 358 684253 YOR116C RPO31
SGTC_3244 9134489 49.47 µM 0.400820585000624 0.32724859325377 no 1130 0.344276111060503 388 16584271
SGTC_167 3672-0051 66.205 µM 0.399183273929915 0.327959577724472 no 1131 0.344879083316291 394 3237971
SGTC_1257 0669-0121 16 µM 0.399049925233541 0.328017510451875 no 1132 0.344928208996213 379 4307855
SGTC_946 3434-1334 87.4 µM 0.398399841260169 0.328299995678907 no 1133 0.345167737453671 362 4047976
SGTC_2743 auranofin 4.32 µM 0.39645706291531 0.329144788563773 no 1134 0.345883938566355 340 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_131 0141-0277 33.849 µM 0.394651742216597 0.329930592671296 no 1135 0.34654996092196 383 1547771
SGTC_2236 dapsone 200 µM 0.393928695522039 0.33024552491855 no 1136 0.346816841921535 354 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2077 5212015 200 µM 0.391418156891612 0.331339954986996 no 1137 0.347744086748772 380 780900
SGTC_219 mitoxanthrone 164.414 µM 0.391283116667995 0.331398864610719 no 1138 0.347793988519741 377 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2519 cryptotanshinone 88.04 µM 0.391212229918693 0.331429789746259 no 1139 0.347820184543098 357 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1521 st012942 49.4 µM 0.390675765393803 0.331663865632751 no 1140 0.348018457229772 353 24207259
SGTC_1967 st070177 51.4 µM 0.390256021021404 0.331847058796696 no 1141 0.348173620131285 399 5729214
SGTC_348 k064-0012 10.7 µM 0.390241353995132 0.331853460798546 no 1142 0.348179042410852 372 5066323
SGTC_2074 5212007 75.395 µM 0.390081323177723 0.331923315747917 no 1143 0.348238206510691 400 758611
SGTC_2741 miltefosine 3.04 µM 0.388310068634465 0.332696874694423 no 1144 0.348893293521028 390 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1806 st050005 60.3 µM 0.38654241426742 0.333469572113 no 1145 0.349547498378541 380 5194765
SGTC_539 4859-0462 2.54 µM 0.386386228655546 0.333537879810785 no 1146 0.349605323843549 377 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2954 9074818 52.69 µM 0.38496455597852 0.334159901155323 no 1147 0.350131837905681 392 16648742
SGTC_3292 9120825 59.784 µM 0.384564098228615 0.334335194904967 no 1148 0.350280198822898 408 24824900
SGTC_1313 1220-0047 237 µM 0.38434289325983 0.334432039211725 no 1149 0.350362160267763 382 3528706
SGTC_502 l-744,832 89.3 µM 0.383273794054664 0.334900249798679 no 1150 0.350758383873329 413 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2994 9053520 71.4286 µM 0.38249508254273 0.335241447137452 no 1151 0.351047087845297 398 4647384
SGTC_1804 st050076 49.1 µM 0.382412294198948 0.335277729371155 no 1152 0.351077786331087 370 3895976
SGTC_1297 1068-0111 14.1 µM 0.382300638136354 0.335326665400755 no 1153 0.351119190704347 379 767057
SGTC_1708 st033234 31.827 µM 0.382252145643758 0.335347919304766 no 1154 0.351137173272288 360 674664
SGTC_780 0109-0199 192 µM 0.3816150180209 0.335627216598962 no 1155 0.351373471529122 401 610414
SGTC_116 0155-0182 31.788 µM 0.378939446537508 0.336801095611994 no 1156 0.352366415362732 344 771486
SGTC_3127 9126946 49.47 µM 0.378056369487932 0.33718888636254 no 1157 0.352694359592074 402 27243249
SGTC_71 0417-1750 47.813 µM 0.37753845856708 0.337416400129035 no 1158 0.352886744727048 338 6811472
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.377122972662108 0.337598962460696 no 1159 0.353041109879694 408 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2298 7976326 193.81 µM 0.376529606777426 0.337859750594218 no 1160 0.35326160457628 369 2235818
SGTC_3160 9100216 49.47 µM 0.376446828696338 0.337896138285576 no 1161 0.353292368819547 390 17191039
SGTC_540 1187-0821 17.3 µM 0.375956351502632 0.338111773928809 no 1162 0.353474672965137 413 847520
SGTC_2479 5617353 43.85 µM 0.375814316517936 0.338174228763235 no 1163 0.353527471844815 417 2731746
SGTC_3088 9117578 49.47 µM 0.375694297216543 0.338227006455299 no 1164 0.353572088998261 374 678341
SGTC_875 0709-0210 25.7 µM 0.375374488281353 0.338367655833098 no 1165 0.35369098773309 397 6251364
SGTC_1877 wortmannin 25 µM 0.375059797321898 0.338506076382832 no 1166 0.353807997637849 411 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1001 4048-4355 44.4 µM 0.374054708911477 0.338948322508771 no 1167 0.354181806891326 400 21824233
SGTC_2928 9011484 9.79 µM 0.37325280083449 0.339301327124209 no 1168 0.354480150795974 401 2994751
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.373178823836788 0.339333899342726 no 1169 0.354507677887009 377 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2275 7947463 200 µM 0.371589536618751 0.340033955236474 no 1170 0.355099240357467 381 1225414
SGTC_2183 6420625 130.508 µM 0.371528376817387 0.340060906204868 no 1171 0.355122012172096 374 2897619
SGTC_501 nsc-95397 161 µM 0.371483371546366 0.340080738963226 no 1172 0.355138769451852 404 262093
SGTC_2205 7238770 200 µM 0.371385352549889 0.340123935147697 no 1173 0.355175266851856 388 279867
SGTC_1417 3966-0327 90.4 µM 0.370620617886525 0.34046101958703 no 1174 0.355460061607913 395 651118
SGTC_1186 1319-0216 26 µM 0.370485453419127 0.340520611476507 no 1175 0.355510406592538 378 4565136
SGTC_3286 9117135 37.221 µM 0.368059285010867 0.341590946914499 no 1176 0.356414514498995 394 3438150
SGTC_37 0566-0070 1.56 µM 0.367814854429564 0.341698851453037 no 1177 0.356505646040021 418 1626686
SGTC_1039 k821-0043 94 µM 0.367573589439262 0.341805371219274 no 1178 0.356595605382546 401 15992768
SGTC_1969 st069479 40.1 µM 0.367014176768055 0.342052403315659 no 1179 0.35680422164284 421 3895485
SGTC_850 0388-0143 75.9 µM 0.364791947412672 0.343034388753844 no 1180 0.35763335826761 380 67273
SGTC_765 1319-0117 244 µM 0.363738896170727 0.343500094682204 no 1181 0.35802649754785 375 3487746 YGL099W LSG1
SGTC_541 4513-1321 94 µM 0.363637324054408 0.343545026952584 no 1182 0.358064425789525 378 747515
SGTC_2444 5485484 36.41 µM 0.363111571345984 0.343777638538157 no 1183 0.358260770517062 403 6790631
SGTC_1141 3253-0389 52.6 µM 0.362267561474094 0.344151182020257 no 1184 0.358576048196111 413 5402031
SGTC_867 0518-0118 155 µM 0.361276951096923 0.344589802266834 no 1185 0.358946211083256 418 6848158
SGTC_2603 homopterocarpin 100 µM 0.360311320263353 0.34501756333499 no 1186 0.359307167358626 383 101795 A weak amylase inhibitor.
SGTC_1757 st041620 31.8375 µM 0.358715857616418 0.345724765094365 no 1187 0.359903832108737 390 5289815
SGTC_2588 indole-3-carbinol 100 µM 0.358043828669754 0.346022808757147 no 1188 0.360155257127611 421 3712 Induces cell cycle arrest.
SGTC_3030 9087619 49.47 µM 0.357698066895415 0.346176190686281 no 1189 0.360284639957009 390 25236973
SGTC_236 1509-0011 5.31 µM 0.357120703573389 0.34643236864906 no 1190 0.360500722928872 408 3107280
SGTC_314 1671-0008 2.74 µM 0.356973212928456 0.346497821993974 no 1191 0.360555929663523 393 3913060
SGTC_1811 st050069 61.5 µM 0.355140837202713 0.347311374675879 no 1192 0.361242042196669 411 3877702
SGTC_1508 1080-0625 72.9 µM 0.355128453815095 0.347316875149442 no 1193 0.361246680538901 384 767111
SGTC_1210 3013-0140 750 nM 0.350688391342785 0.349291134298456 no 1194 0.362911067754479 408 905973
SGTC_383 2324-0395 7.37 µM 0.349888728447312 0.34964713741243 no 1195 0.363211103213385 401 3146421
SGTC_2093 5331342 194.4 µM 0.348368322958954 0.350324373573757 no 1196 0.363781794474817 419 33839
SGTC_38 0929-0051 58.268 µM 0.3424597792734 0.352960727366959 no 1197 0.366002453784469 415 1379719
SGTC_2557 derrustone 83.84 µM 0.339941628184909 0.354086467776626 no 1198 0.36695024333965 403 629853 An antioxidant.
SGTC_193 1273-0060 1.558 µM 0.339833402601473 0.354134878744731 no 1199 0.36699099585194 390 2847393 YHR072W ERG7
SGTC_2064 5220758 200 µM 0.339689527626585 0.354199239884343 no 1200 0.367045174518873 369 788518
SGTC_2436 5633522 8.09 µM 0.339431318797866 0.354314757660124 no 1201 0.367142414260754 394 5724242
SGTC_483 fpl-64176 144 µM 0.338899300011511 0.354552815118627 no 1202 0.367342795891933 414 3423
SGTC_2145 5634607 200 µM 0.338216999706805 0.354858200799863 no 1203 0.367599833016906 387 308662
SGTC_1242 0402-0103 60.1 µM 0.337821995866315 0.355035040257558 no 1204 0.367748666535769 383 432868
SGTC_3108 9121785 49.47 µM 0.337735063232558 0.355073963364174 no 1205 0.367781424554966 420 17140271
SGTC_2258 7960471 200 µM 0.337588843574533 0.355139434978481 no 1206 0.367836525323647 415 2974708
SGTC_3329 9141233 27.5565 µM 0.336647027200135 0.355561247029568 no 1207 0.368191500374172 402 4909101 YNL103W MET4
SGTC_2278 7948257 134.34 µM 0.335581028418739 0.356038890241832 no 1208 0.368593416155111 401 1247028
SGTC_377 3970-0964 33.1 µM 0.335372502101067 0.356132351306231 no 1209 0.368672054103928 382 16481235
SGTC_1876 myriocin 605 nM 0.335053337264424 0.356275417065353 no 1210 0.368792425906902 432 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_337 1315-0038 354 µM 0.334466221441057 0.356538644785091 no 1211 0.369013888016824 421 1626437
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.334289557666194 0.35661786366875 no 1212 0.369080534716501 433 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2249 haloperidol 116.36 µM 0.333549727119866 0.356949682765284 no 1213 0.369359679741957 409 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_925 2064-1272 59.6 µM 0.333191227466227 0.357110511281293 no 1214 0.369494969822557 401 6815817
SGTC_961 1252-1571 372 µM 0.332065899811581 0.35761551559189 no 1215 0.369919749258518 419 6813498
SGTC_3165 9101544 49.47 µM 0.33129946061102 0.357959607220934 no 1216 0.370209149346769 408 5002184
SGTC_338 4055-0136 114 µM 0.330138827719639 0.358480891143954 no 1217 0.370647533054527 382 2900563
SGTC_928 2764-0428 58.7 µM 0.326684078093048 0.360034107286219 no 1218 0.37195342196918 391 662578
SGTC_1827 berberine 7.24 µM 0.324097911220758 0.361198334438676 no 1219 0.372931954130509 418 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_93 0109-0045 59.227 µM 0.323197760896851 0.361603861880986 no 1220 0.373272738268909 394 88733
SGTC_2010 4012422 159 µM 0.322941629345357 0.361719280348977 no 1221 0.373369724171702 414 952393
SGTC_1475 4092-1048 11.7 µM 0.322630722844905 0.361859398508308 no 1222 0.373487461749484 404 2881759
SGTC_1490 4089-0339 670 nM 0.322158605399174 0.362072206012711 no 1223 0.37366627108601 408 742542
SGTC_335 4077-0256 27.6 µM 0.321047899553409 0.362573026079834 no 1224 0.374087046016578 419 3121989
SGTC_3289 9119912 71.43 µM 0.3210355343117 0.362578602924051 no 1225 0.374091731256023 403 17014829
SGTC_3183 9108214 49.47 µM 0.320707274931875 0.362726661752781 no 1226 0.37421611684404 406 4974831
SGTC_3282 9108498 15.4605 µM 0.319189949939016 0.363411305752218 no 1227 0.374791238741385 403 16459645
SGTC_1866 st057638 64 µM 0.31914436034779 0.363431883351769 no 1228 0.374808523188011 424 688802
SGTC_5 0352-0601 109.883 µM 0.319069176263684 0.363465819765269 no 1229 0.374837028386188 395 762456
SGTC_2623 humulene 100 µM 0.318483266311215 0.36373032310316 no 1230 0.375059192959256 380 6187145 An anti-inflammatory.
SGTC_2560 caryophyllene 100 µM 0.317839510161433 0.364021015434781 no 1231 0.375303339377914 390 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1913 st060213 96.1 µM 0.317800417243793 0.364038670621618 no 1232 0.375318167092223 428 688959
SGTC_431 k089-0097 107 µM 0.317753544574861 0.364059839688809 no 1233 0.375335945863409 397 5499420
SGTC_2730 imipramine 71.33 µM 0.315723605258806 0.364977016796976 no 1234 0.376106154032613 371 3696 A tricyclic antidepressant.
SGTC_702 1488-0190 94 µM 0.315418291785463 0.365115032033513 no 1235 0.376222040152267 405 949357
SGTC_749 1000-0129 128 µM 0.314398949490656 0.365575946450006 no 1236 0.376609026957485 420 708470
SGTC_3334 9142812 21.919 µM 0.314275636017182 0.365631718089114 no 1237 0.376655850549442 413 45283678
SGTC_1523 st012844 44.7 µM 0.313476562498878 0.365993188105099 no 1238 0.376959312214926 382 4274103
SGTC_635 k038-0028 24.7 µM 0.310849499851912 0.367182406868945 no 1239 0.377957518511539 423 4035102
SGTC_1149 3909-7961 23.3 µM 0.310458901100556 0.367359332298308 no 1240 0.378106004302012 395 735261
SGTC_2008 4012253 172 µM 0.309815744361936 0.367650717626653 no 1241 0.37835053902808 406 603940
SGTC_815 1582-0027 36.9 µM 0.30964620464316 0.367727541129251 no 1242 0.378415007871276 414 3128206
SGTC_2774 tamoxifen 10.92 µM 0.308027298643225 0.368461381862946 no 1243 0.379030780132793 396 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3049 9092223 49.47 µM 0.30733849270033 0.36877375935172 no 1244 0.379292869789849 412 8623917
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.3062840481842 0.369252123981531 no 1245 0.379694191842682 429 688798
SGTC_2455 5377712 9.75 µM 0.305645476162677 0.369541920309767 no 1246 0.379937295688393 373 2243908
SGTC_720 r052-1644 49.9 µM 0.303376627335987 0.370572166334543 no 1247 0.380801427778267 412 1422863 YOR257W CDC31
SGTC_1751 st044839 27.194 µM 0.302718242370652 0.370871302063129 no 1248 0.38105229715455 388 5291326
SGTC_1657 st012939 43.4 µM 0.302589826322488 0.370929656708828 no 1249 0.381101234318317 421 24207257
SGTC_123 0083-0120 66.675 µM 0.301808547135332 0.371284748456668 no 1250 0.381399007430906 397 16001701
SGTC_220 paclitaxel 373.376 µM 0.301232045099567 0.371546839184801 no 1251 0.381618777768415 424 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2349 9023730 187.07 µM 0.30108481199177 0.371613784203635 no 1252 0.381674911132699 402 4126287
SGTC_280 3448-3607 3.04 µM 0.300875137665151 0.371709127151365 no 1253 0.381754854821259 422 626179
SGTC_782 0083-0095 30.5 µM 0.300481088444601 0.371888330196383 no 1254 0.381905109787165 396 3591729 An indicator and reagent.
SGTC_3043 9092303 49.47 µM 0.299990858993344 0.372111312182567 no 1255 0.382092064084387 381 25236084
SGTC_710 3448-4187 58 µM 0.298171528382991 0.372939213305099 no 1256 0.382786125517494 401 3946412
SGTC_1531 st059297 52.4 µM 0.297774658259772 0.37311989041221 no 1257 0.382937578701429 396 7566702
SGTC_3152 9099253 49.47 µM 0.297432459553082 0.373275700490293 no 1258 0.383068182604915 411 25236131
SGTC_505 gw-5074 63.9 µM 0.295717565042802 0.374056838763009 no 1259 0.383722890931637 430 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_175 3793-3120 23.7 µM 0.294541507733437 0.374592834805859 no 1260 0.384172075357883 432 5322297
SGTC_2664 lyso-paf C-16 73.48 µM 0.293666656737028 0.374991711334208 no 1261 0.384506317736444 419 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3254 9136651 49.47 µM 0.293653054831733 0.374997913996662 no 1262 0.38451151510936 442 16454030
SGTC_1463 k081-0032 34.1 µM 0.293213785256356 0.375198244549412 no 1263 0.384679373911905 406 977755
SGTC_1814 st052110 31.539 µM 0.29240345971659 0.375567884881801 no 1264 0.38498908164768 423 674163
SGTC_158 k038-0087 26.446 µM 0.292287893219122 0.375620611330646 no 1265 0.38503325733464 402 X158
SGTC_1012 4112-3522 18 µM 0.291641881333927 0.375915392734672 no 1266 0.385280225046023 405 3112398
SGTC_2302 7771753 200 µM 0.291314678542794 0.376064726141613 no 1267 0.385405331099314 402 2203047
SGTC_1587 estradiol valerate 56.1 µM 0.29118788406032 0.376122599379694 no 1268 0.385453814202009 435 13791 A steroid.
SGTC_441 propafenone 146 µM 0.291036520452649 0.376191690435122 no 1269 0.385511694279977 430 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1494 4358-1428 177 µM 0.290788285856414 0.376305007569608 no 1270 0.385606622469204 421 1564571
SGTC_761 k216-0224 480 µM 0.290082787866638 0.376627120021646 no 1271 0.385876451616038 449 1340404
SGTC_1361 1608-0041 5.61 µM 0.289812976452915 0.376750331780348 no 1272 0.385979659972588 425 X1361
SGTC_2868 9035608 32.47 µM 0.289717474720554 0.376793946496721 no 1273 0.386016193262989 403 6462614
SGTC_13 0199-0087 65 µM 0.289386881435266 0.376944937388493 no 1274 0.386142666422163 404 4589825
SGTC_1253 0550-0034 176 µM 0.288017263779105 0.377570679070267 no 1275 0.38666676188492 394 5969915
SGTC_1178 0988-0033 191 µM 0.287450299411861 0.377829804108703 no 1276 0.38688377603244 404 5392207
SGTC_3040 9091894 49.47 µM 0.286080813810747 0.378455939550317 no 1277 0.387408113043005 420 25236966
SGTC_1744 st037937 38.9 µM 0.285675060811797 0.378641513164954 no 1278 0.387563503800482 387 1016152
SGTC_237 nikkomycin 200 µM 0.285423416325126 0.378756618373015 no 1279 0.387659884850413 424 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1908 st060353 56.5 µM 0.283446602417152 0.379661210120481 no 1280 0.388417254444933 418 4227716
SGTC_3275 9138069 49.47 µM 0.282313782120825 0.380179887025266 no 1281 0.388851459307265 440 17617007
SGTC_2827 7993847 71.43 µM 0.282010730165004 0.380318679995069 no 1282 0.388967641310629 427 2985692
SGTC_1010 4112-3296 15.2 µM 0.281779431556213 0.380424621444862 no 1283 0.38905632168452 403 704384
SGTC_2974 9094440 9.66 µM 0.281670662617099 0.380474443864733 no 1284 0.389098025923292 383 25236134
SGTC_477 mead ethanolamide 10 µM 0.280566492787465 0.380980329144656 no 1285 0.389521459491834 411 16061185
SGTC_3219 9131112 49.47 µM 0.280048429483784 0.38121775467366 no 1286 0.389720174715464 400 17612988 YMR079W SEC14
SGTC_932 2857-0803 154 µM 0.280037999951026 0.381222534929952 no 1287 0.389724175501441 425 674898
SGTC_2753 fluvastatin 17.09 µM 0.278646307352564 0.381860563498183 no 1288 0.390258135728518 415 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_534 k292-0788 63.4 µM 0.277948840384424 0.382180441662267 no 1289 0.390525815620406 435 4146317
SGTC_1097 itavastatin 7.23 µM 0.277896758687022 0.382204331038139 no 1290 0.390545806067517 418 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2723 salbutamol 83.58 µM 0.273815567406591 0.384077721906719 no 1291 0.392113179805818 434 9884233 β2-adrenoceptor agonist
SGTC_2645 abamectin 100 µM 0.273406171702339 0.384265797355608 no 1292 0.392270504563119 417 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_23 0213-0011 39.996 µM 0.272874545705784 0.384510065786895 no 1293 0.392474826905447 413 627608
SGTC_842 0271-0008 11.1 µM 0.272685459800117 0.384596956944835 no 1294 0.39254750633826 420 1221709
SGTC_2610 ononetin 44.17 µM 0.272634189486624 0.384620518330095 no 1295 0.392567213885619 407 259632
SGTC_1920 st075728 45.7 µM 0.271844746877541 0.384983362169766 no 1296 0.392870698652288 447 3400306
SGTC_438 sphingosine 6.67 µM 0.271346992368932 0.385212192045449 no 1297 0.393062083498009 405 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3344 9148862 3.898 µM 0.271247317296399 0.385258019911424 no 1298 0.39310041131843 425 4905352
SGTC_1316 1272-0050 65.9 µM 0.271128065634836 0.385312850661748 no 1299 0.393146268239948 436 7340392
SGTC_296 1222-0039 74.9 µM 0.268973765839416 0.386303770486225 no 1300 0.393974935390884 408 5984176
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.268175565492356 0.386671109872263 no 1301 0.394282091124339 442 6710655
SGTC_2748 diazoxide 86.69 µM 0.268098988730155 0.386706356570431 no 1302 0.394311562112642 435 3019 A potassium channel activatior.
SGTC_646 4092-0839 27.3 µM 0.26631840985271 0.387526183092004 no 1303 0.394996997954968 453 877796
SGTC_1323 1348-1351 11.2 µM 0.266150122768444 0.387603693012499 no 1304 0.395061797104537 447 6989654
SGTC_2728 chlorpromazine 9.18 µM 0.26610334298534 0.387625239711775 no 1305 0.395079810233383 466 2726 A thorazine and dopamine antagonist.
SGTC_2433 5607874 27.82 µM 0.265137635781914 0.388070120254392 no 1306 0.395451717669145 437 2252428
SGTC_2612 dictamnine 15.46 µM 0.264613268466777 0.388311746590196 no 1307 0.395653698818982 443 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2586 curcumin 80 µM 0.262883091498618 0.389109311325607 no 1308 0.396320344555737 405 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3095 9117207 49.47 µM 0.260039626851693 0.390421085592367 no 1309 0.397416603459304 448 17015229
SGTC_1330 1469-0054 61.8 µM 0.259927195084375 0.390472979443212 no 1310 0.397459966709132 453 7102664
SGTC_2598 perillyl alcohol 100 µM 0.259548514735261 0.390647776969162 no 1311 0.397606027371016 416 10819 An apoptosis inducer.
SGTC_3197 9113331 49.47 µM 0.258447044004889 0.391156337527455 no 1312 0.398030956792547 388 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1450 4112-4260 37.6 µM 0.257942359288971 0.391389417981978 no 1313 0.398225696359981 449 1633175
SGTC_12 0849-0099 9.267 µM 0.257153064407808 0.391754019198536 no 1314 0.39853030750293 450 6071388
SGTC_2845 9003024 42.97 µM 0.254958737536031 0.392768149564713 no 1315 0.399377484448358 408 2990173
SGTC_520 3584-0023 682 µM 0.254937392184688 0.39277801812301 no 1316 0.399385727710768 392 1340790
SGTC_545 4218-0007 221 µM 0.253222435469662 0.393571115716968 no 1317 0.400048165182481 435 2840508
SGTC_1275 0867-0008 21.1 µM 0.252810916749014 0.393761492198634 no 1318 0.400207165667676 436 3422836
SGTC_1958 st076513 41.9 µM 0.252729480905326 0.393799168998892 no 1319 0.400238632391347 445 732122 YGL099W LSG1
SGTC_1154 4088-0362 150 µM 0.252635675595144 0.393842569841985 no 1320 0.400274879466403 428 6618304
SGTC_1737 st035557 69.7 µM 0.252593172481576 0.393862235164572 no 1321 0.400291303270911 422 5716916
SGTC_3188 9110789 49.47 µM 0.246223148957123 0.396812548188088 no 1322 0.402754748398328 433 849217
SGTC_1239 0337-0584 35.4 µM 0.245998652497666 0.396916633927649 no 1323 0.402841637804221 442 914301 YML130C ERO1
SGTC_2408 sulbentine 18.36 µM 0.24392937510842 0.397876380460358 no 1324 0.403642759089596 405 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1013 4112-3890 241 µM 0.243862889869632 0.397907227101421 no 1325 0.403668505591121 411 705171
SGTC_2101 5377231 179.231 µM 0.243710111567005 0.397978112884666 no 1326 0.403727670783657 450 2844213
SGTC_2306 7482397 179.52 µM 0.242646373381794 0.398471757318078 no 1327 0.404139676888459 454 891448
SGTC_2281 7943571 200 µM 0.242361937235604 0.398603781953064 no 1328 0.404249862477489 462 1244024
SGTC_1017 4239-0030 168 µM 0.242361081025558 0.398604179391313 no 1329 0.40425019416976 406 1149593
SGTC_2852 9023854 51.95 µM 0.241809534894096 0.398860219628681 no 1330 0.404463875178406 467 19798528
SGTC_2273 7815444 169.05 µM 0.241600468492466 0.398957284382408 no 1331 0.404544879517623 467 2824616
SGTC_1377 2944-0135 198 µM 0.241223196899116 0.399132458772264 no 1332 0.404691066566668 410 1894137
SGTC_2747 doxorubicin 7.63 µM 0.24090474383561 0.399280338410339 no 1333 0.404814472678731 450 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2377 9073351 62.6 µM 0.240901900506539 0.399281658828523 no 1334 0.40481557456096 440 7337946 YHR072W ERG7
SGTC_442 cape 100 µM 0.240808809627533 0.399324890088668 no 1335 0.404851650712507 449 5281787
SGTC_1989 st071868 50.2 µM 0.240425805658333 0.399502769522919 no 1336 0.405000087392393 456 16414057
SGTC_1246 0422-0085 105 µM 0.239471690205558 0.399945982254717 no 1337 0.405369922930063 469 264295
SGTC_2967 9089538 49.85 µM 0.237821728300056 0.400712738648528 no 1338 0.406009682678596 428 728216
SGTC_1672 st016598 6.51 µM 0.236606175544413 0.401277865090429 no 1339 0.406481164418868 455 4665860 YNL267W PIK1
SGTC_2980 9014342 25.29 µM 0.236367449346125 0.401388876342764 no 1340 0.406573776142588 456 2996599
SGTC_2478 5763493 32.33 µM 0.23634199488887 0.401400713515828 no 1341 0.406583651283249 446 1365576 YLR208W SEC13
SGTC_2729 fluphenazine 10.66 µM 0.23632368049602 0.401409230376367 no 1342 0.40659075644912 447 3372 An atypical antipsychotic.
SGTC_882 0843-0131 351 µM 0.236114543250022 0.401506490142695 no 1343 0.406671894533326 441 5425421
SGTC_2094 5332512 191.667 µM 0.235910671958559 0.401601306838126 no 1344 0.406750993464331 456 755774
SGTC_2190 6049624 200 µM 0.235349585042465 0.401862287684771 no 1345 0.406968706207035 443 2265554
SGTC_2670 beta-carotene 100 µM 0.234857916256096 0.402091015754166 no 1346 0.407159506989858 429 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2712 st079126 47.7 µM 0.233770901908619 0.402596822037306 no 1347 0.407581420307834 435 3152970
SGTC_1487 3970-0795 2.82 µM 0.233156503207247 0.40288278441208 no 1348 0.407819940237624 416 3765103
SGTC_2424 5537928 59.2 µM 0.232894665448311 0.403004668546636 no 1349 0.407921600457398 459 5382802
SGTC_956 1185-0240 191 µM 0.23251135292155 0.403183115558672 no 1350 0.408070435228069 428 1416193
SGTC_813 k007-0158 173 µM 0.232019106889517 0.403412304957939 no 1351 0.408261586773561 466 6523916
SGTC_1437 4092-1038 11.6 µM 0.231988603815512 0.40342650825975 no 1352 0.408273432605113 456 3977136
SGTC_184 1494-0393 24.714 µM 0.231524475377506 0.403642638454245 no 1353 0.408453686652723 438 3090647
SGTC_90 0870-0863 4.608 µM 0.230146738864549 0.404284380634974 no 1354 0.408988873576814 451 1738164
SGTC_1364 1653-0028 37.6 µM 0.228976449942503 0.404829697301936 no 1355 0.409443610058094 468 5718652
SGTC_68 0986-0284 82.829 µM 0.228969311333835 0.404833024230328 no 1356 0.409446384265452 413 423278 YIL048W NEO1
SGTC_317 4495-0002 170 µM 0.228676698919433 0.404969401336423 no 1357 0.409560103254301 436 15991618
SGTC_1727 st034309 9.9045 µM 0.227244344891774 0.40563714108703 no 1358 0.410116873644433 462 870305
SGTC_2445 5742597 35.57 µM 0.226587223122854 0.405943572418922 no 1359 0.41037236419001 424 1774255
SGTC_139 0099-0334 718.624 µM 0.225512478229592 0.40644487537279 no 1360 0.410790309571392 432 97690
SGTC_1761 st044296 37 µM 0.225241063825146 0.406571497931705 no 1361 0.410895872889024 418 1826700
SGTC_1454 4239-0054 42.6 µM 0.224576598153205 0.406881531324322 no 1362 0.411154335921278 470 1340767
SGTC_3336 9143619 71.43 µM 0.224427416842226 0.406951145941606 no 1363 0.411212369588334 460 45595730
SGTC_2561 acetosyringone 100 µM 0.223989436577624 0.407155543939707 no 1364 0.411382761407095 462 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_990 3985-0011 41.3 µM 0.223595279147573 0.407339512180499 no 1365 0.411536118685031 454 5399565 YGL099W LSG1
SGTC_3315 9136395 68.55 µM 0.223537946359586 0.407366273273676 no 1366 0.411558426635267 486 16876844
SGTC_1935 st074532 41.6 µM 0.223435220763384 0.407414223344492 no 1367 0.411598397454091 478 2829742
SGTC_1658 st012944 20 µM 0.222858882356137 0.407683271266522 no 1368 0.411822669353207 458 24207260
SGTC_2383 9036125 200 µM 0.222759863064111 0.407729500118912 no 1369 0.411861203861465 468 79580
SGTC_1211 1056-0033 32.3 µM 0.220564080240081 0.408754967956244 no 1370 0.412715936026431 455 6741922
SGTC_2342 7990637 118.86 µM 0.220224895360084 0.408913428952237 no 1371 0.412848004420402 450 2033102 YER133W GLC7
SGTC_2648 atorvastatin 78.68 µM 0.219057809219686 0.4094587839326 no 1372 0.413302507956628 463 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2174 5790901 200 µM 0.218798318934455 0.409580062175511 no 1373 0.413403578222931 442 786020
SGTC_33 0986-0033 35.816 µM 0.218768801838382 0.409593858159547 no 1374 0.413415075359001 444 2848082
SGTC_1719 st032227 49.2 µM 0.216532553795253 0.410639381573706 no 1375 0.414286326367214 444 3125804
SGTC_1766 st045414 44.774 µM 0.216433948583599 0.410685497603526 no 1376 0.414324753088489 440 253960
SGTC_2948 9070189 9.45 µM 0.215201056460343 0.411262204930756 no 1377 0.414805283643909 453 6473636 YDL196W YDL196W
SGTC_495 decylubiquinone 155 µM 0.214646564525525 0.411521641052339 no 1378 0.415021443367209 469 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3038 9091290 49.47 µM 0.21360779739469 0.412007764281226 no 1379 0.415426459150281 476 25236843
SGTC_2620 irigenin 100 µM 0.213376175164575 0.412116177514015 no 1380 0.415516781034084 483 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2225 6654152 15.4 µM 0.212981016805662 0.412301151038659 no 1381 0.415670884694706 457 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2490 carminic acid 95.39 µM 0.212700646242918 0.412432404243732 no 1382 0.415780231334796 446 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_899 1083-0020 478 µM 0.212170111917534 0.412680796373603 no 1383 0.41598716157244 471 767123
SGTC_3353 9151644 39.2805 µM 0.211583296819778 0.4129555794613 no 1384 0.416216070758864 477 4909158
SGTC_1631 benzylvanillin 81.9 µM 0.211154498441135 0.41315639633672 no 1385 0.41638335758863 417 75506
SGTC_2955 9076254 12.21 µM 0.20942626235385 0.413966001844183 no 1386 0.417057746450153 465 16459619
SGTC_1336 1486-0901 104 µM 0.209041939059748 0.414146090889015 no 1387 0.417207749573555 419 5006114
SGTC_277 nystatin 15.5 µM 0.208560599410343 0.414371666034141 no 1388 0.417395635616647 461 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.207582598450382 0.414830083598465 no 1389 0.417777446411746 431 6708739 YPR165W RHO1
SGTC_1482 3346-2049 8.48 µM 0.207356232890181 0.414936204291392 no 1390 0.41786583040673 453 3826804
SGTC_689 0833-0039 98 µM 0.204677214844021 0.416192603476141 no 1391 0.418912161723454 476 5374726
SGTC_2965 9082772 38.63 µM 0.204635496186513 0.416212175396714 no 1392 0.418928460137508 423 16459634
SGTC_734 2023-0417 80 µM 0.204463332510876 0.416292946583007 no 1393 0.418995721560389 465 3935732
SGTC_2517 totarol 10 µM 0.204377044265725 0.416333430342981 no 1394 0.419029433802523 427 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3081 9117243 49.47 µM 0.202448831304545 0.417238318629426 no 1395 0.419782928388424 448 45595589
SGTC_2117 5521686 200 µM 0.202400471314893 0.417261019076541 no 1396 0.419801829985289 435 803312
SGTC_2742 clothiapine 36.27 µM 0.200485961598013 0.418159921370515 no 1397 0.420550268070434 475 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_150 3970-0969 77.2 µM 0.200207078843964 0.418290898443892 no 1398 0.420659315569299 443 6615640
SGTC_2160 5660466 132.927 µM 0.199858386766065 0.418454674158679 no 1399 0.420795668165429 469 2859134
SGTC_299 1273-0059 1.44 µM 0.19873899497628 0.418980531982657 no 1400 0.421233459418023 448 2848077
SGTC_2021 4019055 173 µM 0.198391906781608 0.419143613407673 no 1401 0.421369224527159 451 44827708 YER133W GLC7
SGTC_1140 3229-1848 2.98 µM 0.19836719337441 0.419155225677203 no 1402 0.421378891644307 467 2849525
SGTC_446 go6976 132 µM 0.198266461800974 0.419202557887333 no 1403 0.4214182951967 477 3501 A protein kinase C inhibitor.
SGTC_1296 1068-0102 11.9 µM 0.197860393882345 0.419393374779942 no 1404 0.421577146304147 467 767053
SGTC_1942 st076330 65.2 µM 0.196291053770146 0.420131007080114 no 1405 0.422191181621731 466 24208414
SGTC_700 3453-2283 142 µM 0.196027118008217 0.420255091664722 no 1406 0.422294470325657 434 565664
SGTC_1124 fisetin 1.16336 µM 0.195179317117381 0.420653723351626 no 1407 0.422626285111179 436 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1626 st003712 1.76 µM 0.194586006924885 0.420932743230219 no 1408 0.422858529258892 459 24207035
SGTC_3146 9095609 49.47 µM 0.193383834570636 0.421498218352004 no 1409 0.423329187312011 443 17173999
SGTC_2859 9028643 45.46 µM 0.193257987876704 0.421557423219405 no 1410 0.42337846342451 454 17151580
SGTC_138 0850-0259 40.9225 µM 0.191891579719536 0.422200366969596 no 1411 0.423913566643537 462 6813004
SGTC_940 3232-1287 54.8 µM 0.191517977502762 0.422376196306213 no 1412 0.424059898603626 470 1585493 YIL048W NEO1
SGTC_1706 st031321 9.9705 µM 0.189139622466271 0.423495888706072 no 1413 0.424991693833544 446 6103185
SGTC_2339 9000433 200 µM 0.187259091251799 0.424381651453939 no 1414 0.425728748012637 433 2988954
SGTC_2569 tetrandrine 100 µM 0.185335889529314 0.425287907895943 no 1415 0.426482794922348 418 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_513 4245-1575 41.7 µM 0.1853100475459 0.425300087926459 no 1416 0.426492928856395 450 719745
SGTC_2671 danthron 100 µM 0.185232045626993 0.42533685278734 no 1417 0.426523517603937 449 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2388 9080168 200 µM 0.184722952302505 0.425576821089549 no 1418 0.426723171324198 490 15943073
SGTC_1640 st009078 66.4 µM 0.184492659389132 0.425685381956565 no 1419 0.426813492639167 473 690618
SGTC_2361 9034121 116 µM 0.184269226972589 0.425790714146298 no 1420 0.426901126922197 450 6496917
SGTC_1965 Pectolinarigenin 58.4 µM 0.182924266112016 0.426424877328499 no 1421 0.427428721267473 441 5320438 An anti-inflammatory.
SGTC_829 1635-0120 117 µM 0.182517489595556 0.426616714282694 no 1422 0.427588315083179 464 285054
SGTC_2862 9027634 71.43 µM 0.181803199820402 0.426953617340815 no 1423 0.427868586639789 463 5012562
SGTC_177 1327-0068 8.361 µM 0.181651936344498 0.427024969359775 no 1424 0.427927943766973 441 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1951 sophoraflavanone G 9.2 µM 0.180532904019523 0.427552898599722 no 1425 0.428367112536169 451 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_687 k029-0044 34.9 µM 0.179617325890808 0.427984940193701 no 1426 0.428726500904574 483 5829338
SGTC_2017 5132927 60.65 µM 0.179475626967493 0.428051812591942 no 1427 0.428782126728121 447 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1401 3807-4679 7.6 µM 0.177989550973062 0.428753265017695 no 1428 0.429365590914599 460 3291456
SGTC_198 3454-2873 16.191 µM 0.177734179307906 0.428873827390065 no 1429 0.42946587069035 473 710957
SGTC_2779 methotrexate 400 µM 0.177280955597035 0.429087813139452 no 1430 0.429643854544085 479 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2013 4024628 200 µM 0.176572844962039 0.42942218329661 no 1431 0.429921962738951 456 5230760
SGTC_640 3381-0960 37.1 µM 0.175728020509293 0.429821176013165 no 1432 0.430253810332535 461 1745025
SGTC_1029 k015-0030 64.7 µM 0.175303520694153 0.430021685380545 no 1433 0.43042057274789 446 2208316
SGTC_2880 9042983 58.44 µM 0.175154207906617 0.43009221647153 no 1434 0.430479232406238 457 6464714
SGTC_1353 1498-1206 8.11 µM 0.174719141169974 0.430297742268394 no 1435 0.43065016332243 473 6756808
SGTC_284 0988-0104 32.6 µM 0.174321291922092 0.430485703032904 no 1436 0.430806483444122 469 4666532
SGTC_2905 7799065 20.05 µM 0.174059512042719 0.430609387482944 no 1437 0.43090934606412 468 1296806
SGTC_1016 4226-1401 38 µM 0.17340287104421 0.430919663869678 no 1438 0.431167384262488 492 2901613
SGTC_2800 7887935 81.82 µM 0.173293217751421 0.430971481467631 no 1439 0.431210477246437 457 2961002
SGTC_2344 7990960 76.95 µM 0.172437968272073 0.431375677607546 no 1440 0.431546612424827 467 140813
SGTC_1369 1866-0067 208 µM 0.172370055769616 0.43140777655764 no 1441 0.43157330592357 463 3531355
SGTC_1198 1612-1005 86.7 µM 0.171695132277158 0.431726804784963 no 1442 0.431838606433071 476 6998509
SGTC_3240 9133527 49.47 µM 0.170901184828914 0.432102151200188 no 1443 0.432150732505568 474 17617455
SGTC_679 0422-0091 41.4 µM 0.170791801086415 0.432153868245132 no 1444 0.43219373806847 484 627384 YHR062C RPP1
SGTC_631 k072-0230 41.5 µM 0.168642450958025 0.433170323844064 no 1445 0.433038943860005 451 5773147
SGTC_3232 9132874 49.47 µM 0.168184301550826 0.43338704606197 no 1446 0.433219145288633 482 3784940
SGTC_527 4476-4215 268 µM 0.168156534880071 0.433400181405245 no 1447 0.433230067049728 447 4418754
SGTC_2052 5265182 7.135 µM 0.166973808577967 0.433959751820075 no 1448 0.433695328657524 481 1239884
SGTC_1520 flindersine 88 µM 0.166448438169975 0.43420835712548 no 1449 0.433902028707638 473 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_887 0885-0007 9.62 µM 0.165314023788749 0.434745250705622 no 1450 0.434348410649012 483 5719458
SGTC_2311 7694451 200 µM 0.164576736061128 0.435094257497064 no 1451 0.434638571716929 495 2163142
SGTC_1927 st060202 13.8 µM 0.163800466673484 0.435461771522881 no 1452 0.434944112144681 487 688887
SGTC_88 0180-0332 8.668 µM 0.163618312002463 0.435548018224869 no 1453 0.43501581404495 445 3101745
SGTC_2618 avocadyne 43.43 µM 0.163154739597762 0.435767524582497 no 1454 0.43519830059381 474 3015189
SGTC_3128 9127691 49.47 µM 0.163148374255658 0.435770538776105 no 1455 0.435200806424343 483 41316314
SGTC_53 0973-0023 39.979 µM 0.162404104370962 0.43612300011003 no 1456 0.4354938194633 475 674768
SGTC_1445 4239-0156 97.7 µM 0.161809378597634 0.436404678832696 no 1457 0.43572798366098 485 4008346
SGTC_1903 st060211 78.3 µM 0.161643024425969 0.43648347458943 no 1458 0.435793487114277 463 688960
SGTC_225 nsc-122657 1.016 µM 0.161541795068672 0.43653142438816 no 1459 0.435833347947551 479 275685
SGTC_941 3237-0776 460 µM 0.16083404695307 0.436866692873059 no 1460 0.436112054357866 488 760008
SGTC_1562 morin hydrate 59.1 µM 0.159268656373021 0.437608397277526 no 1461 0.436728607052911 458 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2848 9016370 25.97 µM 0.159160464887845 0.437659668079253 no 1462 0.436771225598297 489 7894410
SGTC_3251 9135047 49.47 µM 0.15874435374006 0.437856868502626 no 1463 0.436935145996356 476 17682963
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.158101529837225 0.4381615413385 no 1464 0.437188397569373 464 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2368 9071271 200 µM 0.157240646452942 0.438569623040955 no 1465 0.437527597738913 477 27209959
SGTC_1413 3910-0535 34.4 µM 0.155334426340066 0.439473454086118 no 1466 0.438278838346818 489 2876951
SGTC_207 4185-0010 4.486 µM 0.154552436939822 0.439844324599016 no 1467 0.438587084571444 465 3761753
SGTC_948 3448-0295 75.3 µM 0.154487063279691 0.43987533145959 no 1468 0.43861285538817 447 678569
SGTC_971 1315-0384 26.7 µM 0.154323968359121 0.439952689320963 no 1469 0.438677149837321 480 6769120
SGTC_1392 3455-1037 33.9 µM 0.153531239689668 0.440328722558453 no 1470 0.438989678315007 486 981132
SGTC_1788 fluconazole 20 µM 0.153106180390107 0.440530372909625 no 1471 0.439157271048957 485 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1050 3232-1156 69.3 µM 0.152523086935089 0.440807020570125 no 1472 0.439387191358937 489 700529
SGTC_2488 5268135 45.7 µM 0.151717778629052 0.441189145151666 no 1473 0.439704767092351 470 1270356 YLR208W SEC13
SGTC_2009 4012297 12.05 µM 0.149517777714915 0.442233339499604 no 1474 0.440572541226787 451 45595307
SGTC_1383 3049-0032 20.7 µM 0.149481961703608 0.442250342322817 no 1475 0.440586670961162 497 712864
SGTC_3231 9132313 49.47 µM 0.148684233246605 0.442629072978367 no 1476 0.440901401492294 480 4905967
SGTC_2784 7567673 72.73 µM 0.147771935017267 0.443062261187689 no 1477 0.441261379375091 496 3471247
SGTC_3150 9097574 49.47 µM 0.147497097202589 0.443192776286634 no 1478 0.441369835384488 479 17217476
SGTC_274 sirtinol 40.1 µM 0.14727759346851 0.443297018741507 no 1479 0.441456458715817 441 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_354 2783-3500 4.88 µM 0.146584557538794 0.443626167641919 no 1480 0.441729971652498 463 6740761
SGTC_2858 9025781 8.96 µM 0.145843740746714 0.443978052481802 no 1481 0.442022372464905 479 4894980 YPL153C RAD53
SGTC_2757 clomiphene 4.22 µM 0.145144919642878 0.444310030038478 no 1482 0.442298226515795 497 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1 0258-0098 57.368 µM 0.145062068545939 0.444349391354754 no 1483 0.442330933182712 458 6790032 YDR047W HEM12
SGTC_1366 1683-0113 21.9 µM 0.144541541187971 0.444596698653879 no 1484 0.442536427857879 461 708623
SGTC_1649 st011737 51.3 µM 0.144376542347225 0.444675095616026 no 1485 0.442601569610596 485 1761035
SGTC_3162 9099653 49.47 µM 0.142617502824327 0.445511013317915 no 1486 0.443296136767845 494 25237511
SGTC_292 k038-0015 474 µM 0.141777640542655 0.445910212127003 no 1487 0.443627822951288 465 46368540
SGTC_2927 9011802 47.9 µM 0.140841698052378 0.446355143852404 no 1488 0.443997500543097 455 43912568
SGTC_200 k038-0079 37.545 µM 0.140417964863894 0.446556601914907 no 1489 0.444164882282657 475 3436683
SGTC_1223 0764-0573 147 µM 0.139340385757264 0.44706898396859 no 1490 0.444590588962279 474 1609797
SGTC_405 ebelactone b 50 µM 0.139026425983631 0.447218286517313 no 1491 0.444714633455903 480 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2386 9075165 157.42 µM 0.138675425202075 0.447385212651935 no 1492 0.444853319142078 478 16452277
SGTC_1074 carmofur 3.8 µM 0.1380491539688 0.447683072830024 no 1493 0.445100785079617 482 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_778 3456-2434 196 µM 0.134891018609238 0.449185556274728 no 1494 0.446349020379915 474 5539063
SGTC_2412 st077135 33.4 µM 0.134819115635791 0.449219772695231 no 1495 0.446377445866031 485 13258915
SGTC_953 1188-0045 9.7 µM 0.134800209589261 0.449228769565822 no 1496 0.446384920061152 487 6144426
SGTC_972 1319-0219 195 µM 0.134422688247455 0.449408427108404 no 1497 0.446534170910279 505 23903702
SGTC_1195 1502-0147 41.1 µM 0.134352223301519 0.449441961618025 no 1498 0.446562029652971 498 817940
SGTC_91 0417-1751 58.384 µM 0.134176613737454 0.449525536383123 no 1499 0.446631459103957 507 6795624
SGTC_2464 5717415 7.67 µM 0.133735007208079 0.449735712283188 no 1500 0.446806061027432 438 5285744
SGTC_606 k015-0008 38.6 µM 0.132889359451322 0.450138224756073 no 1501 0.447140441096762 480 1970475
SGTC_1335 1486-0900 202 µM 0.132634685053442 0.450259455062845 no 1502 0.447241150023744 483 X1335
SGTC_1263 0774-1208 64.8 µM 0.132239216401232 0.450447715556669 no 1503 0.447397541638148 493 906585
SGTC_227 fluconazole 33.516 µM 0.129552536432143 0.451726986575461 no 1504 0.448460228551793 486 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1113 artemisinin 1.17947 µM 0.128797216474932 0.452086725395425 no 1505 0.448759054058351 495 2240 An anti-malaria and mitochondrial poison.
SGTC_1627 st003713 25.6 µM 0.128168247592825 0.452386316589505 no 1506 0.449007913769298 474 16195070 YER133W GLC7
SGTC_1287 0971-0001 34.6 µM 0.128049693170146 0.452442789612722 no 1507 0.449054823617216 472 4665869
SGTC_48 0382-0018 55 µM 0.127525350788458 0.452692569965109 no 1508 0.449262304976582 444 762596
SGTC_993 3909-8757 62.7 µM 0.126722929290124 0.453074854747743 no 1509 0.449579848596905 472 4288324 YLR208W SEC13
SGTC_2817 7995342 71.43 µM 0.126676577977093 0.453096938491264 no 1510 0.449598192269056 477 18879975
SGTC_1778 st046819 58.9 µM 0.126310900017717 0.453271168157118 no 1511 0.449742914199761 509 671715
SGTC_2540 epiandrosterone 100 µM 0.125333720272546 0.453736795911336 no 1512 0.450129678866788 494 441302 A steroid.
SGTC_1033 k072-0102 21.3 µM 0.1253195084293 0.453743568348756 no 1513 0.450135304219976 488 5965931
SGTC_725 1497-0963 19 µM 0.124638012933677 0.454068340397986 no 1514 0.450405066531622 509 3549977
SGTC_1000 4048-0884 8.67 µM 0.124421823638404 0.454171373537863 no 1515 0.450490647421189 484 13040088
SGTC_2227 7312221 64.1025 µM 0.123640870702503 0.45454359167482 no 1516 0.450799815304464 505 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_396 dithiazanine 1.25 µM 0.12321274363051 0.454747662752719 no 1517 0.450969317252503 495 10578 An antihelmenthic.
SGTC_2678 equilin 100 µM 0.123085996943597 0.454808080130549 no 1518 0.451019499889274 493 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_521 r062-0005 13.8 µM 0.122970212993635 0.454863272724829 no 1519 0.451065342749353 469 2832033
SGTC_2515 chrysin 20.77 µM 0.122810716019876 0.454939304134661 no 1520 0.451128494172301 477 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1144 3486-0183 12.5 µM 0.121826632459936 0.455408448254403 no 1521 0.451518160697633 506 6744069
SGTC_1874 staurosporine 7.6 µM 0.120955463988991 0.455823814056476 no 1522 0.451863155352211 506 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_370 0180-0345 38.7 µM 0.120886964986323 0.455856475858576 no 1523 0.451890283441117 456 3989527
SGTC_2079 5212404 121 µM 0.119844686736247 0.456353493288335 no 1524 0.452303091062834 479 758462
SGTC_614 0462-0418 107 µM 0.119204334331607 0.456658883581203 no 1525 0.452556736418213 488 5188303
SGTC_2090 5301565 104.445 µM 0.119066468596128 0.456724636447353 no 1526 0.452611347953221 481 2056344
SGTC_2750 bromebric acid 70.15 µM 0.118809055448427 0.456847408717361 no 1527 0.45271331714652 477 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1368 1852-0141 284 µM 0.117894338420863 0.457283712941266 no 1528 0.453075689624778 478 2838987
SGTC_1145 3546-0597 10.2 µM 0.11705512550613 0.457684048311443 no 1529 0.453408184925834 483 875334
SGTC_598 3937-0236 20.2 µM 0.116965209671939 0.457726944019276 no 1530 0.453443811429075 502 1379313
SGTC_1087 pterostilbene 9.05 µM 0.115691809220858 0.45833449158766 no 1531 0.453948398978072 490 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1670 st016595 4.04 µM 0.115372157293201 0.458487014925612 no 1532 0.454075073416823 502 597879
SGTC_1739 st037196 92.5 µM 0.115171262902559 0.458582875706205 no 1533 0.4541546879801 485 612214
SGTC_2508 celastrol 40.54 µM 0.11507074586443 0.458630840327843 no 1534 0.454194523632103 484 122724 Celastrol is a natural product and antioxidant.
SGTC_675 1309-0189 238 µM 0.114179291353164 0.459056249995634 no 1535 0.454547833822612 463 4246530
SGTC_1045 1348-1485 165 µM 0.112924350316497 0.459655197879014 no 1536 0.455045265523109 477 6810614
SGTC_2714 st079313 56.9 µM 0.112809531045901 0.459710002464315 no 1537 0.455090780950191 497 2939799
SGTC_963 1269-2853 151 µM 0.112034446538681 0.460079979370464 no 1538 0.455398047052613 465 3668223
SGTC_2164 5685496 200 µM 0.111910442992505 0.460139174129861 no 1539 0.455447208155317 461 759046
SGTC_3179 9107801 49.47 µM 0.111708165924184 0.460235735702476 no 1540 0.455527402194504 463 4818259
SGTC_415 dibenzyl ketone 100 µM 0.110740371992669 0.460697766565432 no 1541 0.455911115315713 509 7593
SGTC_3170 9103054 49.47 µM 0.110562202915264 0.460782831397141 no 1542 0.455981760686535 496 16432970
SGTC_1452 4194-0072 190 µM 0.110159424750747 0.460975139931624 no 1543 0.456141470364714 493 1343545
SGTC_1120 ficusin 1.78878 µM 0.108883452312872 0.461584419664667 no 1544 0.456647465871957 480 6199 A DNA cross-linker.
SGTC_2986 9022445 71.43 µM 0.108856075029108 0.461597493372972 no 1545 0.456658323292464 512 6459286
SGTC_1962 st076595 64.5 µM 0.107088522291171 0.46244165513836 no 1546 0.457359376344312 484 279619
SGTC_3000 9075062 71.4286 µM 0.106909446000136 0.462527189307197 no 1547 0.45743040965958 490 17057871
SGTC_2194 5927483 104.545 µM 0.105339370884639 0.463277195229958 no 1548 0.458053261647929 452 760979
SGTC_119 0121-0043 24.815 µM 0.103734269701896 0.464044067613929 no 1549 0.45869011503214 494 1092378
SGTC_1147 3809-1045 12.3 µM 0.10271699838877 0.464530160702709 no 1550 0.459093791121248 478 325925
SGTC_2835 9006588 71.43 µM 0.10184311584418 0.464947779182442 no 1551 0.459440601027261 435 2345538
SGTC_2404 5161160 200 µM 0.101603074624654 0.465062498916905 no 1552 0.459535869442103 504 2831543
SGTC_2997 9067075 71.4286 µM 0.100158941256807 0.465752735486148 no 1553 0.460109071087842 501 27209819
SGTC_1677 st019204 53.9 µM 0.1000883286403 0.465786488082239 no 1554 0.460137100599084 465 3945625
SGTC_881 0833-0569 170 µM 0.0995095271096813 0.466063162545593 no 1555 0.460366861953141 464 5418700
SGTC_2754 granisetron 64.02 µM 0.0993528127131563 0.466138076839613 no 1556 0.460429073660629 508 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1108 betulinic acid 729.144 nM 0.0970652184357809 0.467231752375685 no 1557 0.461337301031713 467 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1151 3909-8316 15.3 µM 0.0955520112116548 0.467955337827528 no 1558 0.461938190115326 504 800431
SGTC_926 2268-1401 59.4 µM 0.0947276882552471 0.468349557295677 no 1559 0.462265562408246 515 2931578
SGTC_2675 theaflavin digallate 100 µM 0.093253042360391 0.46905486063881 no 1560 0.462851268111923 508 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1623 st003709 20.3 µM 0.0924738850065934 0.469427560501701 no 1561 0.463160769522698 510 16192618
SGTC_111 0083-0039 52.457 µM 0.0918643318532071 0.469719151077977 no 1562 0.46340291532473 515 759313
SGTC_230 MPP+ 141.667 µM 0.0906848819850471 0.47028340784442 no 1563 0.463871491778937 496 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_201 4262-0159 12.803 µM 0.0900332731091757 0.470595167585764 no 1564 0.46413038703576 508 1341029
SGTC_2910 7948405 25.97 µM 0.0888465316967445 0.471163005585533 no 1565 0.464601938469614 513 2971328
SGTC_2118 5526350 200 µM 0.0875790533816849 0.47176953970736 no 1566 0.46510562558822 497 743594
SGTC_425 3825-7017 13.1 µM 0.0875323675732115 0.471791881810725 no 1567 0.465124179278327 519 3397440
SGTC_1664 st014217 9.02 µM 0.0874559690880501 0.471828443495026 no 1568 0.465154541426905 514 3982782
SGTC_1707 st032323 6.317 µM 0.0862927759343864 0.4723851368292 no 1569 0.465616840512724 510 3132057 YMR211W DML1
SGTC_2449 5812982 45.77 µM 0.0862663546867629 0.472397782421251 no 1570 0.465627341905627 516 776185
SGTC_3112 9123419 49.47 µM 0.0860054289896419 0.472522666733715 no 1571 0.465731050755166 510 17015854
SGTC_1480 1070-0044 41.2 µM 0.0850547831019971 0.472977687827332 no 1572 0.466108918920265 504 3124987
SGTC_467 ro 31-8220 72.8 µM 0.0848244941603693 0.473087919610661 no 1573 0.466200460096259 506 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_660 4031-1742 102 µM 0.0848216355782572 0.473089287933378 no 1574 0.466201596410301 500 6738706
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0847575274025365 0.473119974794242 no 1575 0.466227080102659 503 1377
SGTC_748 act1.228 77.9 µM 0.0847181224271345 0.473138836976166 no 1576 0.466242744074761 492 4421505 YNR035C ARC35
SGTC_1428 4049-0204 61.7 µM 0.0845122589959028 0.473237379660204 no 1577 0.466324578221111 507 X1428
SGTC_1244 0416-0015 52.5 µM 0.0840607813059223 0.473453498676203 no 1578 0.466504053110857 503 96201
SGTC_2437 5741531 144.16 µM 0.082961453620809 0.473979771222801 no 1579 0.466941094734863 515 2262990
SGTC_880 0833-0487 87.2 µM 0.0829096161188466 0.474004588113153 no 1580 0.466961703906022 492 76075
SGTC_2969 9091408 28.7 µM 0.0826197687421774 0.474143352646919 no 1581 0.467076940915933 469 4286311
SGTC_3132 9126706 49.47 µM 0.082518266600171 0.474191947575714 no 1582 0.467117296611822 522 850858
SGTC_680 0417-1641 114 µM 0.0824221793230066 0.474237950450278 no 1583 0.467155499751897 494 2835990
SGTC_3217 9129673 49.47 µM 0.0817094945232665 0.474579167069212 no 1584 0.467438864035629 485 17248312
SGTC_1229 0139-0193 12.2 µM 0.0813924807494932 0.47473095177023 no 1585 0.467564914382334 484 3090752
SGTC_372 0155-0182 15.9 µM 0.0805145605813666 0.47515131488511 no 1586 0.467914008080906 503 771486
SGTC_2821 7996764 71.43 µM 0.0803870755134795 0.47521235921601 no 1587 0.467964702941788 503 2987135
SGTC_728 3030-5151 22.5 µM 0.0799322838278326 0.47543013418903 no 1588 0.468145556593744 498 3125388
SGTC_1893 st059353 36.1 µM 0.0783541466574736 0.476185874657401 no 1589 0.468773173503336 516 3112488
SGTC_3072 9116419 49.47 µM 0.0782705376028654 0.476225915888429 no 1590 0.468806426566163 491 17170162
SGTC_1953 st076800 12.1 µM 0.0778707859069681 0.476417364373264 no 1591 0.46896541914707 491 297591
SGTC_3140 9094243 49.47 µM 0.0766128118315884 0.477019866751883 no 1592 0.469465783271754 517 19291112
SGTC_1225 1216-0074 20.6 µM 0.0761796241671307 0.477227352731043 no 1593 0.469638096567581 514 4241466
SGTC_1205 4161-2785 76 µM 0.0759372816416888 0.477343431392553 no 1594 0.469734498007657 481 3498106
SGTC_3302 9125395 16.351 µM 0.0759224438947598 0.477350538527212 no 1595 0.469740400373122 502 17599668
SGTC_336 4111-0029 111 µM 0.0755715930326355 0.47751859472917 no 1596 0.469879968646332 512 3131175
SGTC_2367 9070478 135.38 µM 0.0754491232512205 0.477577258222267 no 1597 0.469928687927859 521 572802
SGTC_3324 9138759 60.749 µM 0.075220323690105 0.477686855386766 no 1598 0.470019707098039 501 45595710
SGTC_2888 9058547 12.99 µM 0.0743145499745508 0.478120746089731 no 1599 0.47038004991972 500 16476514
SGTC_358 0075-0058 9.45 µM 0.0729315517444974 0.478783290411498 no 1600 0.470930293064854 519 1069125
SGTC_1024 4507-0395 26 µM 0.0728193804947242 0.478837030186539 no 1601 0.470974924247128 474 4201836
SGTC_3045 9092950 49.47 µM 0.0722597909948163 0.479105127906775 no 1602 0.471197581573624 503 44120432
SGTC_2890 9046729 58.44 µM 0.07140385426012 0.479515222983362 no 1603 0.471538171092901 507 903329
SGTC_1625 st003711 30.1 µM 0.0704423898143911 0.47997590417199 no 1604 0.471920776416155 509 24207034 YER133W GLC7
SGTC_3129 9127257 49.47 µM 0.0704381374772943 0.47997794171927 no 1605 0.471922468649713 502 837894
SGTC_2330 7979373 200 µM 0.070001979724387 0.480186933574362 no 1606 0.472096041956403 511 1863007
SGTC_1049 3226-0134 66 µM 0.0699539617139614 0.480209942494011 no 1607 0.472115151524675 513 5702385
SGTC_2033 5192550 145 µM 0.0698404776324656 0.480264321229545 no 1608 0.472160314663055 516 182073
SGTC_718 1130-0073 349 µM 0.0693906263272354 0.480479882335599 no 1609 0.472339345021408 514 6740020
SGTC_976 1348-1067 47.6 µM 0.0693883682366644 0.480480964388705 no 1610 0.472340243703072 504 5310671 YGL099W LSG1
SGTC_252 miconazole 1.30953 nM 0.0693373861050372 0.48050539452494 no 1611 0.47236053376231 513 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_977 1348-1378 135 µM 0.0691835415512878 0.480579115766027 no 1612 0.472421761827215 524 X977
SGTC_1320 1313-0481 95.3 µM 0.0690078067166793 0.480663327490174 no 1613 0.472491702727012 514 6813365 YLR208W SEC13
SGTC_1583 clindamycin 39.6 µM 0.0689811957459364 0.480676079480805 no 1614 0.472502293730475 507 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_89 0302-0250 142.109 µM 0.0681000741651496 0.481098324476404 no 1615 0.472852985660158 528 4203518 YLR208W SEC13
SGTC_3234 9132280 49.47 µM 0.0680197664806936 0.481136810031686 no 1616 0.472884949674026 478 17612295
SGTC_2914 7968218 45.32 µM 0.0676291764868172 0.481323993533514 no 1617 0.473040414542798 518 2977111
SGTC_2944 9067346 25.62 µM 0.064307258177914 0.482916127713013 no 1618 0.474362787114623 512 6473075
SGTC_1714 st033236 13.627 µM 0.0643036531568681 0.482917855685711 no 1619 0.474364222339405 519 2916566
SGTC_766 1391-0721 126 µM 0.0628728769774116 0.483603685881544 no 1620 0.474933866568771 517 1020919 YIL115C NUP159
SGTC_824 1304-0008 100 µM 0.0626616431660162 0.483704943142227 no 1621 0.475017970829751 513 768245
SGTC_1641 st009299 47.1 µM 0.0625136001805933 0.483775909809269 no 1622 0.475076915872698 510 4046054
SGTC_213 1246-0773 967 nM 0.0617109850461046 0.484160664526282 no 1623 0.475396495921396 517 6251622
SGTC_1064 honokiol 6.76 µM 0.0614148655840882 0.484302620937952 no 1624 0.475514406841743 521 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1554 st069299 38.7 µM 0.0611962473719894 0.484407425380895 no 1625 0.475601459148397 516 24207999
SGTC_355 1311-2252 105 µM 0.0597569416060024 0.485097447694826 no 1626 0.476174609938403 528 5338538
SGTC_1279 0874-0590 65.2 µM 0.0597054340811489 0.485122141926219 no 1627 0.476195121843827 507 3523074
SGTC_254 nsc-64875 3.808 µM 0.0590170802204839 0.485452164572797 no 1628 0.476469251887507 515 56993
SGTC_3002 9075603 71.4286 µM 0.0585792223665202 0.485662095242323 no 1629 0.476643630203861 522 20105405
SGTC_3143 9086658 49.47 µM 0.05582921934031 0.48698067095638 no 1630 0.477738928785504 500 25236626
SGTC_1578 josamycin 24.2 µM 0.0546609233993256 0.48754089122252 no 1631 0.478204300702113 501 5282165 A P450 substrate.
SGTC_127 0180-0333 59.125 µM 0.0542122827002462 0.487756029618919 no 1632 0.478383017448342 517 771601
SGTC_1671 st016596 74.5 µM 0.0540471181534025 0.487835232508619 no 1633 0.478448812108603 526 2829167
SGTC_1085 doxorubicin 7.67 µM 0.0540362562880394 0.487840441216682 no 1634 0.478453139042911 521 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2957 9076800 11.52 µM 0.0538623996580257 0.487923812853129 no 1635 0.478522396941297 518 16459615
SGTC_1860 st056228 74.6 µM 0.0528001944731464 0.488433196670017 no 1636 0.478945553275654 530 688679
SGTC_3200 9114385 49.47 µM 0.0512445605703276 0.489179239591285 no 1637 0.479565322133401 512 17018030 YLR208W SEC13
SGTC_1247 0448-0043 5.84 µM 0.0510366935611049 0.489278930309143 no 1638 0.479648140700751 509 3089013 YGL099W LSG1
SGTC_2247 cerulenin 830 nM 0.0505832652667028 0.489496391818099 no 1639 0.4798287990677 528 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_889 0919-1524 82.7 µM 0.0503295810005157 0.489618058647273 no 1640 0.479929875702153 489 3905452
SGTC_1404 3909-7820 48.3 µM 0.0484293872211808 0.490529420438848 no 1641 0.480687019580366 526 23741373
SGTC_2124 5246320 200 µM 0.0465161615735958 0.491447082456461 no 1642 0.481449426478164 514 579342
SGTC_1820 st053765 18.6 µM 0.0464491496541601 0.491479224988835 no 1643 0.48147613150059 512 3690829
SGTC_730 1436-0052 41.2 µM 0.0463575739684658 0.491523149718338 no 1644 0.481512625601436 507 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1053 3366-3204 134 µM 0.0456000023253672 0.491886526588096 no 1645 0.48181453366016 519 3632071 YPR165W RHO1
SGTC_648 0375-0473 33.3 µM 0.0455015365831461 0.491933757174093 no 1646 0.481853775076294 517 1713139
SGTC_2938 9059746 27.26 µM 0.0451502727583171 0.492102247109517 no 1647 0.48199376519251 519 6471769
SGTC_2351 9026858 72.31 µM 0.044547938742603 0.492391170586622 no 1648 0.482233820144891 521 1409300
SGTC_2239 6685329 187.64 µM 0.0442286444991088 0.492544329102583 no 1649 0.482361074690081 490 805680
SGTC_2279 7948423 32.93 µM 0.0440782686588603 0.492616461510234 no 1650 0.48242100752181 532 1247112
SGTC_2834 9001755 58.44 µM 0.0431520715894901 0.493060745721627 no 1651 0.482790155400672 522 2989575
SGTC_1347 1493-0251 600 nM 0.0422386946710154 0.493498888712723 no 1652 0.483154208092439 529 3986378
SGTC_1801 st050089 28.441 µM 0.0418261204133519 0.493696801418095 no 1653 0.48331865607524 507 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3242 9133940 49.47 µM 0.0416329118691339 0.493789484483697 no 1654 0.483395668050646 519 17248444
SGTC_2541 muurolladie-3-one 83.07 µM 0.0411773762681967 0.49400800841506 no 1655 0.483577244747522 528 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1166 k206-0078 225 µM 0.0396457479320963 0.494742755115773 no 1656 0.484187777256838 524 5404595
SGTC_3059 1327-0034 3 µM 0.0383539015582515 0.495362488526381 no 1657 0.484702757571399 527 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_20 0481-0013 4.944 µM 0.0377247320127239 0.495664322205355 no 1658 0.484953578367311 535 182045
SGTC_212 3807-4682 38.772 µM 0.0373692952315635 0.495834838228152 no 1659 0.485095277209398 509 3125501 YBL034C STU1
SGTC_2316 5844804 197.44 µM 0.0369897228310503 0.496016933829701 no 1660 0.485246600063383 522 776813
SGTC_145 3737-0113 38.366 µM 0.0368729674877242 0.496072946064697 no 1661 0.485293146952231 521 6849351
SGTC_2219 9098279 200 µM 0.0362343102289895 0.496379336984297 no 1662 0.485547764168512 528 902349
SGTC_195 4234-0266 16.654 µM 0.0362168161935355 0.496387729644455 no 1663 0.485554738701098 537 2303354
SGTC_685 1278-0033 54.9 µM 0.0359628717228 0.496509558182197 no 1664 0.485655981932121 541 3590572
SGTC_2496 diffractaic acid 79.83 µM 0.0343676115840281 0.497274882916402 no 1665 0.486292005209364 535 94870 An apoptosis inducer which activates caspases.
SGTC_2441 5730946 39.09 µM 0.0339271651625229 0.497486188609941 no 1666 0.486467615493213 532 1774275
SGTC_3306 9127676 59.7925 µM 0.0335042769510427 0.497689071355902 no 1667 0.486636227617257 525 41905287
SGTC_1269 0831-0796 3.05 µM 0.0328672048127705 0.49799471102945 no 1668 0.486890242713495 532 927758
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0327850281226481 0.498034135942658 no 1669 0.486923008811264 535 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2920 7982904 15.77 µM 0.0314705205131836 0.49866478365196 no 1670 0.487447150858947 528 6456808
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0312669726695064 0.498762438032029 no 1671 0.487528314757342 526 1273210
SGTC_2881 9058953 51.95 µM 0.0300024581533311 0.499369104605947 no 1672 0.488032546365826 536 17122249
SGTC_366 0181-0206 4.31 µM 0.029986565035094 0.499376729539406 no 1673 0.488038883951147 522 274874
SGTC_2646 retinol 96.75 µM 0.0299763756045193 0.499381618053471 no 1674 0.488042947119239 535 445354 A vitamin A analog and teratogen.
SGTC_1252 0493-0875 34.8 µM 0.0296095280164123 0.499557618091246 no 1675 0.488189233194148 530 3960963
SGTC_169 k015-0017 16.025 µM 0.0288523129285367 0.4999209023929 no 1676 0.488491189270599 535 1840002
SGTC_475 α-linolenic acid 10 µM 0.0287939136073142 0.499948920273083 no 1677 0.488514477553344 511 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_329 k048-0121 21.3 µM 0.0286956596144806 0.499996058982407 no 1678 0.488553659034844 517 6832902
SGTC_2685 mycophenolic acid 18.85 µM 0.0286792306235812 0.499996058982407 no 1679 0.488560210557532 538 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2798 7813637 45.45 µM 0.0276108614708595 0.4994834942768 no 1680 0.488986259384024 537 956368
SGTC_794 k038-0031 316 µM 0.0273302257551554 0.499348855562814 no 1681 0.489098174600741 537 6624242
SGTC_3333 9141820 12.094 µM 0.0270040968160775 0.499192390964569 no 1682 0.489228233218785 535 1939433
SGTC_2682 pyrogallin 40.03 µM 0.0262047142880198 0.498808877379309 no 1683 0.489547027858461 533 822798 An ATP competetive kinase inhibitor.
SGTC_2308 7584454 197.62 µM 0.0257983888047309 0.49861393813821 no 1684 0.489709073485016 531 893577
SGTC_401 neomycin 50 µM 0.0255784891092763 0.498508438910034 no 1685 0.489796771830141 514 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0251246368698157 0.498290698787535 no 1686 0.48997777450125 530 688761
SGTC_2499 avocadenofuran 51.48 µM 0.024941130424052 0.498202659887304 no 1687 0.490050960046809 512 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2837 9008476 45.46 µM 0.0246900419340846 0.49808219802427 no 1688 0.490151099023111 537 2992805
SGTC_3337 9144342 33.5465 µM 0.0243925119542853 0.497939455684218 no 1689 0.490269760572522 536 17682949
SGTC_1524 corynanthine 62.1 µM 0.02400316877444 0.497752665643056 no 1690 0.490425040559941 524 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2846 9008642 19.48 µM 0.0239263143270961 0.497715794255651 no 1691 0.490455692245385 535 2992898
SGTC_1530 rhein 70.4 µM 0.0236185477397837 0.497568141566786 no 1692 0.490578438660427 535 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1963 st076565 50.3 µM 0.0234072212029465 0.497466756706678 no 1693 0.490662722449177 536 4914280
SGTC_1276 0871-0068 94.2 µM 0.0232802246036393 0.497405829593104 no 1694 0.490713372959717 537 3414906
SGTC_1493 4348-0038 111 µM 0.023198535378268 0.497366638900681 no 1695 0.490745953446522 538 800424
SGTC_3340 9146634 11.102 µM 0.0229998049346461 0.497271297380114 no 1696 0.490825214274269 539 4907387
SGTC_2187 6125751 200 µM 0.0228604493403559 0.497204441212499 no 1697 0.490880794499092 535 874498
SGTC_843 0310-0051 143 µM 0.0228051182626877 0.497177896022105 no 1698 0.49090286265218 538 2065037
SGTC_488 nitrendipine 139 µM 0.0214667537079916 0.496535817148977 no 1699 0.491436662023032 538 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1443 4112-3303 14 µM 0.0214104907522969 0.496508825244884 no 1700 0.49145910253729 532 704433
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0212772222845293 0.496444890351025 no 1701 0.491512256854812 534 65057 A dermal irritant. YDR527W RBA50
SGTC_3207 9114163 49.47 µM 0.021123992318974 0.496371379139449 no 1702 0.49157337303028 533 849233
SGTC_3010 9080089 71.4286 µM 0.0209525498493958 0.496289130727975 no 1703 0.491641753545382 530 17027233
SGTC_217 ketoconazole 989 nM 0.0204570836670251 0.496051434943441 no 1704 0.491839373588665 537 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1449 4112-4002 201 µM 0.0203738248787704 0.496011492366787 no 1705 0.49187258211828 533 2059539
SGTC_1622 st003707 19.4 µM 0.02001270260112 0.495838248009093 no 1706 0.492016619692503 540 10140899
SGTC_331 k048-0133 24.5 µM 0.0189035627245428 0.495306155656113 no 1707 0.49245901870323 543 6813582
SGTC_1327 1436-0082 2.18 µM 0.0184935748875949 0.495109472524686 no 1708 0.492622551593663 525 15992205
SGTC_315 k915-0449 187 µM 0.0182921838294439 0.495012859788655 no 1709 0.49270288141266 535 20970215 YNL149C PGA2
SGTC_722 3534-0461 190 µM 0.0182318353327992 0.494983909039747 no 1710 0.492726952965249 536 658262
SGTC_2552 juarezic acid 87.02 µM 0.0181074393316867 0.49492423311486 no 1711 0.492776571598456 535 1549512
SGTC_2713 st079149 53.4 µM 0.0170442105681367 0.494414180012511 no 1712 0.493200672976444 539 3103253
SGTC_3264 9137442 49.47 µM 0.0167533880236012 0.494274667903256 no 1713 0.493316677820244 530 17015726
SGTC_3175 9106517 49.47 µM 0.016552793999856 0.494178440229359 no 1714 0.493396692161603 532 41468073
SGTC_1906 st060206 94.7 µM 0.0165510372387132 0.4941775974887 no 1715 0.493397392911902 539 5133468
SGTC_1875 nocodazole 6 µM 0.0158630068084811 0.493847542577899 no 1716 0.493671841288601 537 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1129 3453-1384 223 µM 0.0149860058409379 0.493426842792255 no 1717 0.494021672425715 534 1084452
SGTC_907 3448-6986 75.5 µM 0.0147527966963564 0.493314972932936 no 1718 0.494114699128826 534 590582
SGTC_550 4123-0385 25.7 µM 0.0142297267194618 0.493064059462858 no 1719 0.494323351946491 541 5731123
SGTC_3185 9108267 49.47 µM 0.0141949566533397 0.493047380570885 no 1720 0.494337221795098 543 4910486
SGTC_1839 st053978 48 µM 0.0135394665699747 0.492732950105392 no 1721 0.494598699356837 541 3788398
SGTC_1066 ketoconazole 628 nM 0.0134657187944709 0.492697574490849 no 1722 0.494628117780659 539 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_779 1360-0071 233 µM 0.0127562670445063 0.492357264941084 no 1723 0.494911123748545 543 7566
SGTC_1782 st039423 80.636 µM 0.0125033635337034 0.492235953611783 no 1724 0.495012009605013 536 2068169
SGTC_3189 9110682 49.47 µM 0.0114277572779503 0.49172002102846 no 1725 0.495441083679453 545 17122418
SGTC_1326 1431-2094 10.8 µM 0.0113913066982016 0.491702537134238 no 1726 0.495455624410391 537 616278
SGTC_2916 7875993 68.79 µM 0.0110685227503003 0.491547711204319 no 1727 0.495584388454549 540 1299250
SGTC_2373 9071805 200 µM 0.0105671507793962 0.491307226619162 no 1728 0.495784395226558 531 10149009
SGTC_874 0599-0792 117 µM 0.00975357901889736 0.490917001220989 no 1729 0.496108946638368 544 765305
SGTC_3278 9139605 49.47 µM 0.00943573048995746 0.490764549193733 no 1730 0.496235744018339 531 7958859
SGTC_2546 rhodinyl acetate 100 µM 0.00925100960186202 0.490675950774255 no 1731 0.496309433773994 534 6708682
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.00920852802638203 0.490655575230949 no 1732 0.49632638074873 535 2724 A muscle relaxant with antifungal properties.
SGTC_404 fumagillin 50 µM 0.0082920731003061 0.490216019709913 no 1733 0.496691979357228 538 12015870 A methionine aminopeptidase binder.
SGTC_2818 7996756 12.99 µM 0.00784131401294231 0.489999828301933 no 1734 0.49687180036322 544 2241621
SGTC_309 k408-0051 1.48 µM 0.00745622398688503 0.489815135171136 no 1735 0.497025424561571 545 3640463
SGTC_1130 3454-2858 15.9 µM 0.0071570476979924 0.489671648656221 no 1736 0.497144775446128 547 715628 YIL048W NEO1
SGTC_2686 alizarin 95.37 µM 0.00681864556811124 0.48950935083456 no 1737 0.497279775066815 541 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1976 st070609 63.5 µM 0.00671150112100779 0.489457964667792 no 1738 0.49732251853874 546 682556
SGTC_2514 salinomycin 42.74 µM 0.00551963270865714 0.488886360020023 no 1739 0.497797996321403 543 23682228 A polyether potassium ionophore.
SGTC_666 0272-0154 136 µM 0.00528462340707379 0.488773655261031 no 1740 0.497891750099859 545 6870312
SGTC_1907 st060210 83.7 µM 0.00462756609802061 0.488458551303365 no 1741 0.498153874817084 543 688793
SGTC_173 1273-0061 2.693 µM 0.00431094537150595 0.488306712551197 no 1742 0.498280186949713 547 2847414 YPL266W DIM1
SGTC_1397 3532-0190 20.1 µM 0.00425148911254138 0.488278199874108 no 1743 0.49830390634787 545 5322280
SGTC_605 1315-0399 119 µM 0.00349290207183708 0.487914419305227 no 1744 0.498606536515703 545 24020461
SGTC_2930 9013230 14.89 µM 0.00300439005985235 0.48768015857452 no 1745 0.498801423581438 546 2995857
SGTC_2873 9040596 71.43 µM 0.0020330250651872 0.487214363548429 no 1746 0.499188940903091 548 6463863
SGTC_2026 5148700 152 µM 0.00184834036450745 0.487125804337916 no 1747 0.499262619299885 547 79838
SGTC_1760 st045453 10.4495 µM 0.00158195918864007 0.486998071505577 no 1748 0.499368889857017 548 3323419 YIL048W NEO1
SGTC_1230 0170-0365 3.77 µM 0.00148716533689318 0.486952617086369 no 1749 0.49940670708786 548 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2376 9072922 81.32 µM 0.000614010290689353 0.486533940221116 no 1750 0.499755045349834 547 17087968
SGTC_3055 9094636 49.47 µM 0.000499544771403661 0.486479055223496 no 1751 0.499800710478022 548 25236176
SGTC_1504 k297-0033 30 µM 0.000399741556462009 0.486431200853645 no 1752 0.499840526196141 546 4388117
SGTC_2978 9011784 42.97 µM -0.000153105475277178 0.486166121304152 no 1753 0.49993891975279 548 2994934
SGTC_1690 st023502 41.2 µM -0.000534531432808217 0.485983238428613 no 1754 0.499786752821404 548 24207482
SGTC_183 3914-0051 30.55 µM -0.000648647395626169 0.485928523648068 no 1755 0.499741227146959 549 1596232
SGTC_2147 5545932 89.7195 µM -0.000720577783217924 0.4858940355734 no 1756 0.499712531080834 548 797404
SGTC_392 N-ethylmaleimide 8.33 µM -0.00248394218230121 0.485048598392171 no 1757 0.499009051460428 548 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1730 st033808 45.1 µM -0.00249196818255539 0.485044750512972 no 1758 0.499005849559494 548 1045166
SGTC_26 0302-0163 425.158 µM -0.00371121736981504 0.484460226224068 no 1759 0.498519441878076 551 3100915
SGTC_664 1222-0054 14.9 µM -0.00392686453524513 0.484356845542122 no 1760 0.498433411733684 550 6813991
SGTC_2259 7964009 200 µM -0.00397338773138462 0.484334542582343 no 1761 0.498414851808527 551 313134
SGTC_3196 9111891 49.47 µM -0.00418548619414963 0.484232864388778 no 1762 0.498330237468351 549 18891510
SGTC_1572 epiandrosterone 68.9 µM -0.00437627564890659 0.484141402427601 no 1763 0.498254124185736 549 441302 A steroid.
SGTC_1955 wogonin 32.4 µM -0.0061348082584156 0.483298424878387 no 1764 0.497552580955364 549 5281703 A flavanone.
SGTC_1212 0520-0165 585 µM -0.00683388207967523 0.482963334453517 no 1765 0.497273696719767 554 5403258
SGTC_747 3448-8087 38.7 µM -0.0069536677453389 0.482905918214019 no 1766 0.497225910288694 555 5168703
SGTC_2597 laccaic acid a 100 µM -0.00712719218928557 0.482822744274757 no 1767 0.497156685767077 554 5491415 A textile dye.
SGTC_847 0342-0274 5.54 µM -0.00835093401805921 0.482236200343892 no 1768 0.496668498061501 557 18097
SGTC_1376 2910-0861 41.3 µM -0.00878468337981978 0.482028311852881 no 1769 0.496495463454476 555 1112859
SGTC_822 1487-0950 154 µM -0.00936530968922099 0.481750035465774 no 1770 0.496263836611871 552 1958375
SGTC_514 4466-0038 2.65 nM -0.0096208332079572 0.481627573687617 no 1771 0.496161902070081 556 5722064
SGTC_2352 9027995 87.8 µM -0.00987309737855929 0.481506675679796 no 1772 0.496061268007263 555 2997347
SGTC_1861 st057647 17.4 µM -0.0100856433797049 0.481404813988045 no 1773 0.495976478643135 550 688668
SGTC_1950 st077106 7.18 µM -0.0114337864886822 0.480758751161092 no 1774 0.495438678529511 551 13831864
SGTC_2379 9035213 200 µM -0.0117872943539056 0.480589349925087 no 1775 0.495297658801731 553 646551
SGTC_1613 st002381 52.1 µM -0.0126508047196269 0.480175569906364 no 1776 0.494953193734149 555 551167
SGTC_489 paxilline 115 µM -0.0136256025516771 0.479708488447506 no 1777 0.494564339241496 564 105008 A toxic potassium channel blocker.
SGTC_618 k072-0232 33.2 µM -0.0139665624834417 0.479545121564801 no 1778 0.494428328853625 557 5872756 YGL099W LSG1
SGTC_3281 9140613 49.47 µM -0.0152324337361956 0.478938624735514 no 1779 0.493923373140415 554 16013766
SGTC_1916 st067606 49.2 µM -0.0153665116518902 0.478874388940429 no 1780 0.49386989005088 557 19590279
SGTC_567 1080-0542 68.4 µM -0.0169857030153748 0.478098689453594 no 1781 0.493224010734473 551 5950415
SGTC_1812 st052057 4.327 µM -0.0172905222552823 0.477952670117658 no 1782 0.493102423309596 560 3645418
SGTC_671 0560-0003 407 µM -0.0184178260550088 0.477412677077463 no 1783 0.492652765859543 564 3238678
SGTC_1791 st048313 56.1 µM -0.0188627451904024 0.477199566438945 no 1784 0.492475299640445 553 1204976
SGTC_2893 9048488 25.97 µM -0.0192721057789083 0.477003493652655 no 1785 0.492312018079468 553 6467338
SGTC_3243 9134147 49.47 µM -0.0198179272112457 0.47674206843583 no 1786 0.492094308422612 554 24282180
SGTC_3178 9107506 49.47 µM -0.0202247683623355 0.476547215358653 no 1787 0.491932034814456 557 8897194
SGTC_2988 9073640 71.4286 µM -0.0202311949619946 0.476544137438777 no 1788 0.491929471496605 558 9102229
SGTC_510 ag-490 170 µM -0.0206270160570622 0.476354567790802 no 1789 0.491771594675591 556 5328779
SGTC_1179 1021-1431 9.29 µM -0.0211583591247738 0.476100101350557 no 1790 0.491559665721983 557 2840958
SGTC_2949 9072542 2.23 µM -0.0219166981054826 0.47573694080723 no 1791 0.491257202406177 565 16457352
SGTC_2260 7964312 200 µM -0.023708526062844 0.474878933902921 no 1792 0.490542552551903 576 231951
SGTC_2218 6965428 192.983 µM -0.0237419052796736 0.474862951542532 no 1793 0.490529239918298 554 675684
SGTC_3345 9148410 3.559 µM -0.0238272949568322 0.474822066148074 no 1794 0.490495183999982 559 4903596
SGTC_2413 inermin 26.06 µM -0.0239788447993128 0.474749503286584 no 1795 0.49043474162983 586 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2102 5377816 72.7585 µM -0.024938070144461 0.474290240674809 no 1796 0.490052180542104 562 1379702
SGTC_934 2950-0684 338 µM -0.0260359345928303 0.473764641717568 no 1797 0.489614338248973 557 1121253
SGTC_1886 st057356 49.9 µM -0.0265463756087949 0.47352028527333 no 1798 0.489410772115406 559 24207747
SGTC_643 k048-0106 28.4 µM -0.0278655493959214 0.47288882162476 no 1799 0.488884692683318 564 6763920
SGTC_2600 tangeritin 87.95 µM -0.0281637803753588 0.472746073456581 no 1800 0.488765762415406 565 68077 A bioactive flavone.
SGTC_1775 st081588 35.1725 µM -0.0285573062134088 0.472557717792638 no 1801 0.488608831445273 561 1426443 YGL099W LSG1
SGTC_2731 amoxapine 43.43 µM -0.0287099142162457 0.472484675745554 no 1802 0.488547974613548 556 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_221 trifluoperazine 10.304 µM -0.0299252448612618 0.471903021011727 no 1803 0.488063336187481 560 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_565 1418-0001 44.5 µM -0.0302532643151082 0.471746041796332 no 1804 0.48793253458402 575 2862145
SGTC_3295 9122362 53.5725 µM -0.0306546979088031 0.471553934987194 no 1805 0.487772459999194 567 4730473
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0313113236565775 0.471239719774608 no 1806 0.48751062993236 591 5024745
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.031589422271556 0.471106646590169 no 1807 0.487399739492951 556 5282362
SGTC_1233 0325-0408 14.2 µM -0.0320952694110355 0.470864601563382 no 1808 0.487198037965784 569 12874
SGTC_918 glabranin 770.725 nM -0.033677264705503 0.470107695534816 no 1809 0.486567254411685 566 124049 Also referred to as licorice root.
SGTC_548 1436-0017 110 µM -0.0341449878468407 0.469883933846928 no 1810 0.486380767134488 566 9677137
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0352249576021929 0.46936730598222 no 1811 0.485950180644315 564 4330530
SGTC_1835 st008666 49.2 µM -0.0355524958225821 0.469210630846862 no 1812 0.485819593597072 570 690455
SGTC_356 1634-0012 32.5 µM -0.0360893222160437 0.468953854806835 no 1813 0.485605568210112 566 735457
SGTC_1824 st053723 68.6 µM -0.0362668091482704 0.468868961682845 no 1814 0.485534807491546 577 675225
SGTC_617 3770-0098 35 µM -0.0365760839761962 0.468721036957812 no 1815 0.485411506494769 563 5962639
SGTC_305 1682-2595 20.8 µM -0.0371786172845653 0.468432860472203 no 1816 0.485171293879137 567 226033
SGTC_352 k048-0007 5.11 µM -0.0379895006495948 0.468045061543589 no 1817 0.484848026627285 569 6811911
SGTC_1406 3909-7906 11.9 µM -0.0380929738544349 0.467995578428037 no 1818 0.484806776648964 563 X1406
SGTC_1476 4112-3294 3.34 µM -0.0382684918338281 0.467911643080544 no 1819 0.484736806125102 563 704369
SGTC_1909 st060837 51.5 µM -0.0383197091265514 0.467887150466659 no 1820 0.484716388357736 575 678937
SGTC_1872 amphotericin b 148 nM -0.0383543332854474 0.46787059292168 no 1821 0.484702585463802 562 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_698 k064-0052 127 µM -0.0399943556139973 0.467086385526775 no 1822 0.48404881313094 557 5088751
SGTC_2587 piperic acid 92.2 µM -0.0400142823195124 0.467076857978618 no 1823 0.484040869884114 568 5370536
SGTC_3117 9124945 49.47 µM -0.0408618590711023 0.46667162396219 no 1824 0.483703012043999 562 17592065
SGTC_1513 0337-0559 19 µM -0.0408938998862412 0.466656305637265 no 1825 0.483690240283414 565 775073
SGTC_3320 9137005 35.139 µM -0.0413164786678521 0.466454280479317 no 1826 0.483521798105042 557 4908713
SGTC_1850 st056238 17 µM -0.0417454617221118 0.466249202427164 no 1827 0.483350806157331 563 5393177
SGTC_871 0574-0004 149 µM -0.0421892423255479 0.466037059744113 no 1828 0.483173919153339 566 9551173
SGTC_2725 haloperidol 53.21 µM -0.0423234339229338 0.465972913354531 no 1829 0.483120432225908 566 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_226 1,3-diallylurea 8.28947 mM -0.0427375998148812 0.465774938979557 no 1830 0.4829553533103 563 74537 YKL182W FAS1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0434517913014641 0.465433570062728 no 1831 0.48267069658432 570 6708514
SGTC_176 1486-1328 72.834 µM -0.0436222807169751 0.465352083361853 no 1832 0.482602745578386 567 22310231
SGTC_1581 himbacine 57.9 µM -0.0436926612716683 0.465318444868853 no 1833 0.48257469454443 599 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2869 9037858 32.47 µM -0.0438101644648476 0.465262284591604 no 1834 0.482527862396796 562 27187042
SGTC_1854 st056233 32.9 µM -0.0440268236412193 0.465158734842567 no 1835 0.482441511209802 573 5393174
SGTC_1100 amiodarone 5.07 µM -0.04413187631586 0.465108526979878 no 1836 0.482399641951758 566 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1232 0279-0259 161 µM -0.0455309543453061 0.464439918382975 no 1837 0.481842051237772 574 1560000
SGTC_2321 7390090 138.78 µM -0.0458543054011249 0.464285405622803 no 1838 0.481713187422987 573 649046
SGTC_690 glyoxal 20.3 µM -0.046098063004568 0.464168930019717 no 1839 0.481616044933679 573 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2158 5657123 3.6195 µM -0.0466246636154004 0.463917312985144 no 1840 0.481406187340225 602 2858827
SGTC_2495 cafestol 54.53 µM -0.04677799565201 0.463844051531678 no 1841 0.48134508337859 605 16667697 An anti-infammatory.
SGTC_3310 9130229 44.1445 µM -0.046962560353806 0.463755868857942 no 1842 0.481271533548042 598 7761258
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0477466889478442 0.463381242065209 no 1843 0.480959062055577 566 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3151 9099821 49.47 µM -0.0480418314660514 0.463240242598436 no 1844 0.480841452194418 599 17174189
SGTC_2844 9010103 25.97 µM -0.0486386680854842 0.46295512788347 no 1845 0.480603626871055 584 2480525
SGTC_3025 9087895 49.47 µM -0.0489448740558184 0.462808857660735 no 1846 0.480481613684474 571 17173641
SGTC_1615 st002656 86.5 µM -0.0501360045737668 0.462239919614488 no 1847 0.480007004151341 566 1584458
SGTC_1477 0139-0234 16 µM -0.0502896807711317 0.462166522482978 no 1848 0.479945773458835 578 620880
SGTC_151 3013-0144 2.285 µM -0.0505553802641727 0.462039625060439 no 1849 0.47983990935918 561 906558 YHR107C CDC12
SGTC_2119 5528445 120.635 µM -0.0515172317388892 0.461580279574534 no 1850 0.47945668557071 585 791935
SGTC_691 1548-0686 185 µM -0.051984313514262 0.46135723665448 no 1851 0.479270596257558 568 46495133
SGTC_951 1171-0579 82.7 µM -0.0523833728125298 0.461166685748747 no 1852 0.479111611249871 575 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1789 tunicamycin 25 nM -0.0526021299162777 0.461062232962306 no 1853 0.4790244599472 570 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0530563881743447 0.460845340979672 no 1854 0.478843489837185 575 1273210
SGTC_890 0929-0006 47.2 µM -0.0537363080072236 0.460520725493371 no 1855 0.478572627486445 580 1378169
SGTC_1051 3253-3903 78 µM -0.0555490434784022 0.459655396725714 no 1856 0.477850529595517 563 5509239
SGTC_1214 0358-0031 63.7 µM -0.0561052616714271 0.459389918111718 no 1857 0.477628976167762 618 4301366
SGTC_1987 st072290 61.9 µM -0.0564573021667874 0.459221901273057 no 1858 0.477488754588155 580 54697379
SGTC_146 3448-8650 53.125 µM -0.0577729288769566 0.458594062535848 no 1859 0.476964750889152 595 2891488 YIL048W NEO1
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0578090806975707 0.458576811742373 no 1860 0.476950352463416 571 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1555 citronellol 128 µM -0.0601449348500998 0.457462364219261 no 1861 0.476020100940979 572 8842 A terpine precursor.
SGTC_321 4534-3890 65.3 µM -0.0620143491959922 0.456570697901779 no 1862 0.475275702494983 583 699746
SGTC_930 2810-3379 265 µM -0.0625449914906118 0.456317633752671 no 1863 0.475064417010525 612 1015764
SGTC_2842 9000675 19.48 µM -0.0635954765153247 0.455816708136471 no 1864 0.474646166835397 563 2989072
SGTC_8 0354-0001 70 µM -0.0640629277296161 0.455593825739826 no 1865 0.474460060284677 585 4993152
SGTC_3343 9148379 18.9835 µM -0.0653318618749385 0.454988864098055 no 1866 0.473954887208851 578 1955036
SGTC_2539 epi(13)torulosol 80 µM -0.0656665595710757 0.454829315025113 no 1867 0.473821648261396 591 6708597
SGTC_2277 7947813 106.88 µM -0.0659803806486118 0.454679724372655 no 1868 0.473696722693285 592 1246798
SGTC_3054 9094397 49.47 µM -0.0671338559319699 0.454129946965023 no 1869 0.473237570772927 600 2598354
SGTC_2324 6149169 200 µM -0.0677662210828888 0.453828581916854 no 1870 0.472985866798058 585 2888231
SGTC_969 1313-0238 134 µM -0.0682572592609386 0.453594587119461 no 1871 0.472790423453676 578 5212874
SGTC_400 oxethazaine 37.5 µM -0.0731715445639948 0.451253679635484 no 1872 0.470834804910253 603 4621 A local anesthetic.
SGTC_2687 chenodiol 100 µM -0.0742315328672682 0.450748976209241 no 1873 0.470413077729347 590 5702181 A cholesterol synthesis inhibitor.
SGTC_1780 st038448 24.544 µM -0.0745263275044641 0.450608626641642 no 1874 0.470295796547012 626 728868 YDL195W SEC31
SGTC_1007 4101-0031 70 µM -0.0747737393695635 0.450490840430683 no 1875 0.470197368128489 625 1146276
SGTC_1176 0848-0131 83.3 µM -0.0750118752496837 0.450377474387605 no 1876 0.470102631715629 580 6769040
SGTC_2698 st077697 67.5 µM -0.0753213039940979 0.45023017498976 no 1877 0.469979535745969 574 3154499
SGTC_2108 5365811 200 µM -0.0754603178654788 0.450164001534058 no 1878 0.46992423461825 568 780283
SGTC_1439 4092-1168 46 µM -0.0758720175693189 0.44996803216084 no 1879 0.469760459708309 586 2886240
SGTC_2099 5377090 177.372 µM -0.0774128863724502 0.449234686094678 no 1880 0.469147544851775 599 2243829
SGTC_3293 9120939 62.045 µM -0.0777827029620771 0.449058704899581 no 1881 0.469000452897383 586 934087
SGTC_2396 5342950 42.78 µM -0.077858915944854 0.449022439377614 no 1882 0.468970140243259 575 1886677
SGTC_2726 cimetidine 79.27 µM -0.0779854465158516 0.448962231453097 no 1883 0.468919814865399 584 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1259 0671-0132 43 µM -0.0780327214679194 0.448939736584283 no 1884 0.468901012186416 595 X1259
SGTC_265 mycophenolic acid 32.932 µM -0.0780874760186851 0.448913682898677 no 1885 0.468879234731393 576 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_263 alizarin 107.927 µM -0.0792752348274676 0.448348569769421 no 1886 0.468406852019684 584 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_42 0133-0086 60.653 µM -0.0795147602924883 0.448234620753605 no 1887 0.468311595884953 592 162923 Model of phenazepam hydroxylation.
SGTC_2952 9073731 13.78 µM -0.0795786568544295 0.448204224079126 no 1888 0.468286185366937 587 16457353
SGTC_2142 5622915 118.518 µM -0.0808656687456251 0.447592035761254 no 1889 0.467774391445132 579 5322196
SGTC_3041 9091929 49.47 µM -0.0808894607937978 0.447580719853877 no 1890 0.46776493078378 581 25236887
SGTC_788 1182-0090 188 µM -0.0817671423630602 0.44716330929536 no 1891 0.467415942573895 585 5715185
SGTC_3330 9141424 71.43 µM -0.0824499048379502 0.446838639415958 no 1892 0.467144476391179 580 27261020
SGTC_908 3448-7491 47.7 µM -0.0830101053187599 0.446572277293359 no 1893 0.466921752232758 591 1203031
SGTC_3173 9105693 49.47 µM -0.0838209055105904 0.446186803635434 no 1894 0.466599413158388 608 17096658
SGTC_1970 st070122 35.8 µM -0.0852833745165423 0.44549163997941 no 1895 0.466018054294256 596 102928
SGTC_3015 9080845 49.47 µM -0.0868772801995409 0.444734190673365 no 1896 0.46538452949974 597 5296973
SGTC_1304 1165-0502 251 µM -0.0876244136885264 0.444379210251538 no 1897 0.465087598746409 583 767425
SGTC_673 1082-0474 110 µM -0.0880036943424689 0.444199022283582 no 1898 0.464936869938265 581 3098046
SGTC_1529 apigenin 74 µM -0.0882382406518827 0.444087600215474 no 1899 0.464843662096062 609 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_944 3370-0224 231 µM -0.0893965198955354 0.443537420458479 no 1900 0.464383394560287 589 4580514
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0899738625640249 0.443263224701098 no 1901 0.464153992610076 589 688667
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0901138397921335 0.443196749789788 no 1902 0.464098375701203 582 6312947
SGTC_2374 9071832 200 µM -0.0902682138585328 0.443123439702054 no 1903 0.46403703933511 578 17381698
SGTC_848 0368-0089 85.6 µM -0.0909371124590275 0.442805811626627 no 1904 0.46377128043508 587 762535
SGTC_888 0916-0002 6.97 µM -0.0914575777704407 0.442558692862968 no 1905 0.463564506474486 593 2802138 YIL048W NEO1
SGTC_3109 9122853 49.47 µM -0.0914623025237973 0.442556449635637 no 1906 0.46356262943768 626 1234709
SGTC_3273 9137859 49.47 µM -0.0915080923458401 0.442534709552781 no 1907 0.463544438227208 580 2377234
SGTC_1797 st048695 56.8 µM -0.0939553105724742 0.441373073153528 no 1908 0.462572328315516 582 592262 YIL048W NEO1
SGTC_160 3453-0671 289.699 µM -0.0954687049024289 0.44065495243352 no 1909 0.46197127328353 615 5322268
SGTC_22 0964-0034 14.468 µM -0.0970075481682226 0.439924956018141 no 1910 0.461360200076192 583 138402
SGTC_312 4092-0653 6.84 µM -0.0979873729885816 0.439460252991217 no 1911 0.460971160004368 598 1148278
SGTC_258 haloperidol 50.781 µM -0.0987120257663812 0.439116624421096 no 1912 0.460683460160921 576 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1944 st076371 56.9 µM -0.0988857844683074 0.439034235280226 no 1913 0.460614477966465 584 24208455
SGTC_883 0850-0245 24.6 µM -0.101811884237855 0.437647200147089 no 1914 0.459452996206825 585 6823229 YPR165W RHO1
SGTC_983 1491-0821 12.2 µM -0.102692953607164 0.437229703282657 no 1915 0.459103333142198 587 46495113
SGTC_1286 0929-0070 131 µM -0.103049159508255 0.437060934062495 no 1916 0.458961977475675 602 1420408
SGTC_872 0588-0139 234 µM -0.103183286270268 0.436997388196908 no 1917 0.458908752363076 587 2047100
SGTC_1334 1486-0610 236 µM -0.104146469188472 0.436541104350663 no 1918 0.458526557127824 591 3742339
SGTC_1052 3253-3998 198 µM -0.104233260845895 0.436499993108476 no 1919 0.458492119692567 609 5450317
SGTC_2232 chlorophetanol 41.5365 µM -0.104725997596255 0.436266607884477 no 1920 0.458296616146673 601 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1167 k781-0610 148 µM -0.105302648804582 0.43599350468124 no 1921 0.458067830610575 611 4525169
SGTC_1608 st001473 40.5 µM -0.10583226081345 0.435742706220288 no 1922 0.457857720045778 634 7292267
SGTC_2029 5175081 200 µM -0.105892876997874 0.43571400299279 no 1923 0.45783367281244 597 1380876
SGTC_2665 lovastatin 100 µM -0.107210584077956 0.435090120809419 no 1924 0.457310959473746 601 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_927 2425-1185 123 µM -0.10757617132899 0.434917058269358 no 1925 0.457165949900863 612 730375
SGTC_118 0083-0097 135.343 µM -0.108858071533809 0.434310328099526 no 1926 0.456657531507522 604 5207356
SGTC_40 0327-0103 19.753 µM -0.109633535874349 0.433943371717089 no 1927 0.456350006589481 610 409036
SGTC_1101 ebselen 5.29 µM -0.109989819477867 0.433774794322335 no 1928 0.456208724403122 590 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_604 1000-0114 314 µM -0.11096779549915 0.433312122006467 no 1929 0.455820942221042 604 1572745
SGTC_368 fentichlor 4.58 µM -0.111103255996195 0.43324804396383 no 1930 0.455767233409028 602 7329 A pesticide.
SGTC_1941 st076221 61.8 µM -0.111960886466809 0.43284239244786 no 1931 0.455427209799544 596 2828568
SGTC_2152 5568786 200 µM -0.112457439880955 0.432607559456622 no 1932 0.455230356836895 614 5399883
SGTC_760 0568-0725 82.9 µM -0.113114805989795 0.432296710595769 no 1933 0.454969768423921 583 3916171
SGTC_819 1013-0258 27.7 µM -0.113818780837509 0.431963868319811 no 1934 0.454690725193476 620 5753198
SGTC_911 3456-4043 236 µM -0.114839566793819 0.431481322251003 no 1935 0.454286143370054 592 914281
SGTC_1126 isoteolin 1.0172 µM -0.115317507565865 0.431255425123969 no 1936 0.454096730952819 591 133323
SGTC_2011 4012611 177 µM -0.116091867019393 0.430889474443373 no 1937 0.453789867205015 611 2049887
SGTC_2676 harmalol 100 µM -0.116854900276789 0.43052893438622 no 1938 0.453487518792468 600 5459187 A monoamine oxidase inhibitor
SGTC_1721 st082152 9.2685 µM -0.117317611335438 0.430310327444471 no 1939 0.453304184786543 609 5296051
SGTC_471 1-acyl-paf 4 µM -0.117761655073157 0.430100559924099 no 1940 0.453128256448491 599 16759367
SGTC_1931 st074438 57.1 µM -0.117819027965095 0.430073458245186 no 1941 0.453105526210452 610 2787313
SGTC_2297 7971671 152.32 µM -0.118887097299736 0.429568986320621 no 1942 0.452682402060918 608 909016
SGTC_2372 9071633 200 µM -0.119921067208255 0.429080729809075 no 1943 0.45227283784432 578 21321366
SGTC_1510 1123-0200 71.5 µM -0.121342614212162 0.428409630684895 no 1944 0.451709834054111 647 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_571 k831-0106 44.2 µM -0.121765022081472 0.428210255657639 no 1945 0.451542558051853 605 4783639
SGTC_1711 st032263 62.8 µM -0.122969737608715 0.427641734991893 no 1946 0.451065530971989 606 3958979
SGTC_2865 9030313 51.95 µM -0.123042324457594 0.427607485115569 no 1947 0.451036791256381 592 42562754
SGTC_1084 voriconazole 435 nM -0.124478104784959 0.426930129125006 no 1948 0.450468367693913 612 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1424 4048-1941 275 µM -0.124752374305517 0.42680076183615 no 1949 0.450359796268044 595 X1424
SGTC_2689 tacrolimus 100 µM -0.124861584675066 0.426749251743144 no 1950 0.45031656564576 599 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2544 sphondin 68.51 µM -0.125609807810951 0.426396378940235 no 1951 0.450020399471146 591 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_281 1672-3440 14.9 µM -0.126873769874283 0.425800410196465 no 1952 0.449520153726119 604 6833000
SGTC_603 3794-0023 45.9 µM -0.126938461690211 0.425769912008059 no 1953 0.449494552414471 631 3802260
SGTC_2647 atorvastatin 60.16 µM -0.127147650173037 0.425671295622379 no 1954 0.44941176904634 623 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2053 5265679 138 µM -0.128943776891208 0.424824751075655 no 1955 0.448701068417713 593 764595
SGTC_2803 7707263 71.43 µM -0.128971948100642 0.424811476264184 no 1956 0.448689922794142 614 2199229
SGTC_3198 9112019 49.47 µM -0.129050428903508 0.42477449506194 no 1957 0.448658872956838 622 45595555
SGTC_817 1391-0715 46 µM -0.129074902315135 0.424762962999002 no 1958 0.448649190456479 603 1353946
SGTC_2492 derrusnin 100 µM -0.129247911489042 0.424681441560517 no 1959 0.448580743112235 600 1715307 Part of coumarin class of compounds.
SGTC_623 k072-0108 16.9 µM -0.12941765773002 0.424601460737728 no 1960 0.448513588164454 626 5382803
SGTC_1374 2889-5571 141 µM -0.129620319784039 0.424505974748898 no 1961 0.448433413006624 597 2853281
SGTC_1929 genistein trimethyl ether 50.5 µM -0.129731410207542 0.424453635409492 no 1962 0.448389465405217 597 136420
SGTC_647 0140-0236 81 µM -0.130473562958396 0.424104010464463 no 1963 0.448095884516589 615 990837
SGTC_2909 7941780 10.49 µM -0.131037361703171 0.423838447222113 no 1964 0.44787287592219 626 1243215
SGTC_1990 st072050 59.8 µM -0.131086148187497 0.423815469197732 no 1965 0.447853579374787 597 17233948
SGTC_726 3448-4391 34.2 µM -0.131251991520835 0.423737360317942 no 1966 0.447787984184736 623 1356692
SGTC_1043 0916-0009 19.3 µM -0.131455133041253 0.423641688824141 no 1967 0.447707638573749 591 3101130
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.132131188107968 0.423323326498177 no 1968 0.447440263815869 584 66535 A nucleotide analog.
SGTC_2035 5154463 94.595 µM -0.132354899295362 0.423217989266563 no 1969 0.447351792955945 606 2769623
SGTC_261 5-fluorouridine 15.376 µM -0.132605232304566 0.423100123321787 no 1970 0.447252797094209 600 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3103 9120822 49.47 µM -0.132950412249469 0.42293761125763 no 1971 0.447116298768681 594 17141819
SGTC_163 TUB2.036 7.546 µM -0.133137475620672 0.422849546569856 no 1972 0.447042328845821 594 15992207 YJR013W GPI14
SGTC_2922 7999257 32.47 µM -0.134387093236662 0.422261357416739 no 1973 0.446548243580175 589 2988377
SGTC_1418 3966-3099 2.4 µM -0.134460579111848 0.422226773343256 no 1974 0.446519190636888 596 740335
SGTC_768 0384-0033 77.3 µM -0.13463382107554 0.422145244228173 no 1975 0.446450699849714 614 3965305 YMR134W ERG29
SGTC_2280 7785178 200 µM -0.134761871424186 0.422084984808603 no 1976 0.446400076483803 600 2954328
SGTC_2968 9090663 33.37 µM -0.134883268314441 0.422027858134969 no 1977 0.446352084299716 662 25236811
SGTC_2132 5317594 122.667 µM -0.135205178057383 0.421876382523235 no 1978 0.44622482659566 603 794577
SGTC_3193 9111931 49.47 µM -0.13560726644616 0.421687194841226 no 1979 0.446065880364742 614 17087244
SGTC_628 1636-0253 16 µM -0.135941337893343 0.421530023736743 no 1980 0.445933827938071 628 4456143
SGTC_429 1112-0049 25.5 µM -0.136210650220805 0.421403329053907 no 1981 0.445827377990324 603 2836170
SGTC_2684 capsaicin 100 µM -0.136530046635102 0.421253083474698 no 1982 0.445701136579091 605 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_457 grayanotoxin iii 135 µM -0.136778132796391 0.421136390485354 no 1983 0.445603084338437 612 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_187 1488-2104 32.728 µM -0.137309881578354 0.420886293656973 no 1984 0.445392930024582 597 2852859
SGTC_2063 5246145 200 µM -0.13923837906068 0.419979534088291 no 1985 0.444630890884446 634 711240
SGTC_1750 st081859 2.357 µM -0.139703491068842 0.419760906604269 no 1986 0.444447133993076 628 5291695
SGTC_2332 7982454 138.89 µM -0.140281710210105 0.419489147261557 no 1987 0.444218707281233 609 2981748
SGTC_2606 farnesol 9.78 µM -0.140819026269089 0.419236646524476 no 1988 0.444006456026324 595 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1498 4478-3555 97.6 µM -0.141732970196983 0.418807233640477 no 1989 0.443645465685814 616 3437919
SGTC_2168 5727979 200 µM -0.143858561061719 0.417808908199727 no 1990 0.442806079357145 604 695210
SGTC_208 k072-0098 12.366 µM -0.143887855710857 0.417795153077121 no 1991 0.442794512815461 608 5948901
SGTC_573 3702-0553 84.7 µM -0.144292588557437 0.417605123554632 no 1992 0.442634715269635 626 1222756
SGTC_3104 9120930 49.47 µM -0.144549612738309 0.417484455955833 no 1993 0.442533241239358 608 17014836
SGTC_3272 9137413 49.47 µM -0.144930553657515 0.417305626277093 no 1994 0.442382851391178 653 17614870
SGTC_1563 conessine 56.1 µM -0.145067482600917 0.417241350252991 no 1995 0.442328795894322 597 441082 An anti-amoebic, histamine inhibitor.
SGTC_3202 9113761 49.47 µM -0.145243920287154 0.417158531630773 no 1996 0.442259145097659 631 4798415
SGTC_2322 7413319 38.22 µM -0.145339195012056 0.417113811865883 no 1997 0.442221535051213 605 1840400
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.146320152294741 0.416653435535188 no 1998 0.441834328918209 598 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3148 9097893 49.47 µM -0.147128732503527 0.416274043964388 no 1999 0.441515205700649 604 17174100
SGTC_3145 9085516 49.47 µM -0.148637552464073 0.415566303753992 no 2000 0.440919819778879 601 25236195
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.149474197585355 0.415173977580362 no 2001 0.440589733984707 610 23665772 A membrane-active detergent.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.149845062347999 0.415000095803929 no 2002 0.440443428041043 618 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_952 1185-0122 232 µM -0.150122838844899 0.414869869824396 no 2003 0.440333850690965 600 678600
SGTC_2921 7974240 10.71 µM -0.151411811765309 0.414265701730693 no 2004 0.439825436221116 628 2979074 YDR527W RBA50
SGTC_2148 5546263 113.568 µM -0.15198465177653 0.413997264856388 no 2005 0.439599520561546 628 792097
SGTC_1068 loratadine 26.9 µM -0.15490429002462 0.412629728546339 no 2006 0.438448385761908 630 3957 A H1 histamine antagonist.
SGTC_2925 9010536 32.5 µM -0.1553793445877 0.412407316425798 no 2007 0.438261133512917 607 2994177
SGTC_1486 3970-0793 4.53 µM -0.156213396167425 0.41201689634703 no 2008 0.437932408875938 631 2844330
SGTC_2516 gossypol 71.55 µM -0.156220418917073 0.412013609362535 no 2009 0.43792964118207 638 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2296 7971656 126.45 µM -0.156869630604014 0.411709773769879 no 2010 0.437673797378792 608 666570
SGTC_2732 terfenadine 20 µM -0.157425389763235 0.411449716654006 no 2011 0.437454802396466 607 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_613 3914-0030 117 µM -0.157658930249451 0.411340447347516 no 2012 0.437362782285642 605 1145395
SGTC_2653 dihydrofissinolide 100 µM -0.157699411825487 0.411321507460308 no 2013 0.437346831994792 612 6857746
SGTC_3070 9117005 49.47 µM -0.159451061171587 0.410502171661235 no 2014 0.436656756229803 611 8779016
SGTC_841 0251-0215 91.2 µM -0.160861323549101 0.409842803497691 no 2015 0.436101312430561 643 3888614
SGTC_3131 9127911 49.47 µM -0.162920884033102 0.408880314384975 no 2016 0.435290363718553 655 45595681
SGTC_1341 1486-1360 280 µM -0.164589564596447 0.408100896633759 no 2017 0.434633522719617 626 3976547
SGTC_128 0906-2981 13.371 µM -0.164824744943138 0.407991076281056 no 2018 0.434540963385047 638 6740226
SGTC_2703 st077852 53.4 µM -0.165656999924275 0.407602502694455 no 2019 0.43421344374354 649 6281836
SGTC_579 4491-1009 110 µM -0.166031022240312 0.407427904067967 no 2020 0.43406626838261 622 1271041
SGTC_1391 3442-0225 151 µM -0.16690218103685 0.407021306826982 no 2021 0.433723508501563 616 5227075
SGTC_2242 6630449 61.2675 µM -0.167399255567223 0.406789351354589 no 2022 0.433527955441254 639 691249 YDR170C SEC7
SGTC_3154 9100113 49.47 µM -0.168312556590328 0.406363252717296 no 2023 0.433168698026479 634 25237525
SGTC_32 0928-0142 34.1 µM -0.168891961342388 0.406092990113279 no 2024 0.432940811143322 629 2244242
SGTC_2661 dactinomycin 12.96 µM -0.169153034271298 0.405971227594634 no 2025 0.432838135292018 614 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1527 coumarin 137 µM -0.170751349638652 0.405225983616635 no 2026 0.432209642255909 676 323 A hepatotoxic, DNA x-linker.
SGTC_981 1488-1094 54.9 µM -0.170953087577381 0.405131943946479 no 2027 0.432130326583228 600 3449522
SGTC_1813 st051246 8.6015 µM -0.171006455737379 0.405107067418964 no 2028 0.432109344713072 611 5291959
SGTC_11 0438-0307 1.3 µM -0.1716621567581 0.404801456493438 no 2029 0.431851569316173 626 4011476
SGTC_17 0960-0276 49.807 µM -0.171670987134444 0.404797341203268 no 2030 0.431848098032724 622 6821114
SGTC_1769 st044406 64.4 µM -0.172160049130389 0.404569436224494 no 2031 0.431655852523908 636 670903
SGTC_3001 9076041 71.4286 µM -0.172935142340057 0.404208305819046 no 2032 0.431351204101357 634 16004211
SGTC_3016 9080866 49.47 µM -0.173025691249744 0.404166122708721 no 2033 0.431315616742112 642 17066299
SGTC_832 4083-0019 164 µM -0.174124552593019 0.4036542961704 no 2034 0.430883788882073 617 1990758
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.174549985272488 0.403456182806242 no 2035 0.430716625538736 617 688669
SGTC_1660 st012960 28.1 µM -0.175524687299075 0.40300238190768 no 2036 0.430333687114354 640 24207266
SGTC_2178 5812956 200 µM -0.175711954135401 0.402915209321266 no 2037 0.430260121692757 616 5403383
SGTC_3063 1327-0034 4 µM -0.176140590666416 0.402715697474197 no 2038 0.43009174633736 606 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_447 ml7 120 µM -0.17666524108873 0.4024715297782 no 2039 0.429885672479081 625 4216 Selective myosin light chain kinase inhibitor.
SGTC_1044 1222-0021 1.78 µM -0.177823420678208 0.401932657985986 no 2040 0.429430826720997 640 4306703
SGTC_1352 1496-0991 99 µM -0.178068318217462 0.401818737165888 no 2041 0.429334661379804 641 3000039
SGTC_62 0180-0423 3.232 µM -0.178153250274149 0.401779230633509 no 2042 0.429301311594171 632 30102 YGL099W LSG1
SGTC_1146 3579-1023 7 µM -0.178527938626365 0.401604954629152 no 2043 0.429154190885535 625 X1146
SGTC_1298 1079-1278 263 µM -0.178613353035382 0.401565229198425 no 2044 0.429120654447873 660 2840950
SGTC_115 0527-0192 112.043 µM -0.179129922207349 0.401324999474421 no 2045 0.428917843728197 642 4233931
SGTC_2406 ethylparaben 405.7 µM -0.179906342262276 0.400963996664198 no 2046 0.42861304801963 676 8434 A possible steroid mimic.
SGTC_1745 st081495 74 µM -0.180469998113773 0.400701973249325 no 2047 0.428391802852864 623 13842402 YBL026W LSM2
SGTC_293 4049-0273 38.5 µM -0.180707382308312 0.400591635202224 no 2048 0.428298631972574 623 1380311
SGTC_2998 9066762 71.4286 µM -0.182207894963689 0.399894368946961 no 2049 0.427709788711674 637 4945196
SGTC_3313 9133968 57.047 µM -0.18252676326897 0.399746236545964 no 2050 0.427584676538189 623 1494643
SGTC_2438 5259590 200 µM -0.18291568967368 0.399565577719775 no 2051 0.427432086006222 637 1201127
SGTC_3328 9140624 29.0385 µM -0.183603196188735 0.399246279124081 no 2052 0.427162377777053 626 4904392
SGTC_344 k064-0035 6.43 µM -0.184409096622696 0.398872080661524 no 2053 0.426846267062889 642 5088750
SGTC_3113 9123498 49.47 µM -0.185932389178857 0.398165034312642 no 2054 0.4262488910826 614 8897275
SGTC_3085 9117376 49.47 µM -0.186802655141341 0.397761244463123 no 2055 0.425907682530999 625 16480349
SGTC_2778 tioconazole 65.09 nM -0.186922724168034 0.397705542891746 no 2056 0.425860610950444 651 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1118 chelidonine 707.474 nM -0.187711453295506 0.397339693162198 no 2057 0.425551425720601 625 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2233 sulbentine 40.3845 µM -0.188413478374398 0.397014136798002 no 2058 0.425276267348689 634 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1040 k898-0338 155 µM -0.191127851455539 0.39575605329262 no 2059 0.424212713768261 627 20969351
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.192953806114297 0.394910352169246 no 2060 0.42349757277046 634 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1831 st055328 12 µM -0.193403534485884 0.394702133758132 no 2061 0.423321473787317 650 1103068
SGTC_814 3342-0569 96 µM -0.194869964870302 0.394023404692788 no 2062 0.422747373981744 624 4346283
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.195101275646687 0.393916373125241 no 2063 0.422656831973069 649 521171
SGTC_1497 4476-2978 41.3 µM -0.195686137060955 0.393645783214029 no 2064 0.422427917827443 615 1528379
SGTC_386 1509-0011 3.07 µM -0.195815659342856 0.393585865834269 no 2065 0.422377226482421 649 3107280
SGTC_1317 1273-0028 910 nM -0.196452713572769 0.3932911994167 no 2066 0.422127920265872 649 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3012 9080433 71.4286 µM -0.197103248381864 0.392990360691059 no 2067 0.421873370726503 624 17688859
SGTC_2813 7971799 71.43 µM -0.199238356494495 0.392003433483107 no 2068 0.42103814834591 658 2234054
SGTC_3075 9116269 49.47 µM -0.199704415325 0.391788095693588 no 2069 0.420855880203443 659 17015205 YNL244C SUI1
SGTC_651 3253-0966 34.4 µM -0.199809831748042 0.391739393691212 no 2070 0.420814655880186 634 781462
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.20133809438379 0.391033532883423 no 2071 0.420217108694197 628 6708784 An antioxidant flavonoid
SGTC_1501 4491-0275 38.4 µM -0.201482865466273 0.390966685828781 no 2072 0.420160513044111 638 5104718
SGTC_1224 0823-0416 294 µM -0.201754839293698 0.390841112490841 no 2073 0.420054194234083 653 3598164
SGTC_3247 9135149 49.47 µM -0.202121245267348 0.390671956779363 no 2074 0.419910969650728 630 8934436 YOR116C RPO31
SGTC_454 lyso-paf C-16 6.67 µM -0.202953912652356 0.390287622869743 no 2075 0.419585527419665 658 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2310 7668677 200 µM -0.203651681664657 0.389965636477837 no 2076 0.41931285161693 648 2197143
SGTC_2830 7992007 71.43 µM -0.203703046554654 0.389941937064757 no 2077 0.419292780654859 607 1952075
SGTC_546 peri-Naphthalide 147 µM -0.203868586120839 0.389865561012134 no 2078 0.419228097075474 627 223824 A penicillin ester.
SGTC_2007 4011539 71.82 µM -0.204026708037819 0.389792611258542 no 2079 0.419166313935805 608 45595301
SGTC_1733 st037357 54.9 µM -0.204241481707079 0.389693531362772 no 2080 0.419082398391079 684 1272339 YGL099W LSG1
SGTC_1897 st060201 15 µM -0.204609432923674 0.389523803902714 no 2081 0.4189386424593 632 611878
SGTC_1934 st074720 32.6 µM -0.205442279672379 0.389139708658793 no 2082 0.418613295139395 622 17250992
SGTC_1637 st007924 17.4 µM -0.205558730794501 0.389086011935653 no 2083 0.418567808535179 611 683336
SGTC_1747 st037496 66.6 µM -0.205975430926672 0.388893884888875 no 2084 0.418405051538632 626 723305
SGTC_2126 5251174 33.877 µM -0.207639739110009 0.388126797235002 no 2085 0.417755136608066 646 790722
SGTC_1676 st018489 23.4 µM -0.208768180653005 0.387606941074688 no 2086 0.417314606071328 626 3696235
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.208894377993663 0.387548816351085 no 2087 0.417265346529479 652 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2777 climbazole 1.536 µM -0.209199628496617 0.387408232677672 no 2088 0.417146201212527 634 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2558 carylophyllene oxide 100 µM -0.210132385663234 0.386978741224108 no 2089 0.416782174806051 632 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3180 9109287 49.47 µM -0.210832031796062 0.386656677375055 no 2090 0.416509171269392 631 18891271
SGTC_2038 4100038 30.985 µM -0.210985500305463 0.38658604257943 no 2091 0.416449292883255 644 3596803
SGTC_1968 st069590 43.6 µM -0.21102182644047 0.386569323809265 no 2092 0.416435119898811 643 6384066
SGTC_2020 4017018 200 µM -0.211358581459073 0.38641434542999 no 2093 0.416303736924081 664 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1015 4130-4525 82 µM -0.212290613094077 0.385985508708628 no 2094 0.415940159104037 641 1363237
SGTC_3093 9117344 49.47 µM -0.212341042374866 0.385962309678625 no 2095 0.415920489107904 634 24824913
SGTC_2030 5175110 200 µM -0.212414947942623 0.385928311566782 no 2096 0.415891662540909 687 2831986
SGTC_2195 6536160 144.242 µM -0.212507026090789 0.385885954912433 no 2097 0.415855748465762 631 3834386
SGTC_2452 5863136 48.41 µM -0.21321741919382 0.385559214408497 no 2098 0.415578691048604 631 2184096
SGTC_885 0865-0106 16.8 µM -0.2132849514426 0.385528157630097 no 2099 0.4155523552632 641 2793380
SGTC_2824 7998404 51.95 µM -0.214787501916805 0.384837353826041 no 2100 0.414966498760767 624 837851
SGTC_1036 k216-0215 33.5 µM -0.215122924668032 0.384683191642591 no 2101 0.414835740501326 640 622330
SGTC_1458 k015-0034 6.33 µM -0.216679711946546 0.383967922495088 no 2102 0.41422897995827 671 3598957
SGTC_2271 7849410 118.62 µM -0.217162382417338 0.383746238662715 no 2103 0.41404089979865 636 972430
SGTC_2044 5102272 200 µM -0.217381916339619 0.383645422368196 no 2104 0.413955361463872 635 592666
SGTC_2069 5228469 200 µM -0.218984629971522 0.382909649192816 no 2105 0.413331010354085 674 2835210
SGTC_3079 9117512 49.47 µM -0.219281820900449 0.38277326122798 no 2106 0.413215261062972 652 7185044
SGTC_428 3448-4153 16.5 µM -0.219617967163974 0.382619013255102 no 2107 0.413084348622332 635 3834874
SGTC_3078 9116413 49.47 µM -0.219810668257853 0.382530596590837 no 2108 0.413009305378889 628 17177322
SGTC_103 0844-0104 51.839 µM -0.219904312191759 0.382487632339089 no 2109 0.412972838936133 645 5375804
SGTC_2889 9059656 51.95 µM -0.221256813995521 0.381867260077552 no 2110 0.412446237040799 653 3949838
SGTC_2231 micatex 6.853 µM -0.221813611629131 0.381611953392104 no 2111 0.412229491425039 650 20737 An antifungal of unknown mechanism.
SGTC_1607 st000305 50.6 µM -0.222131635558991 0.381466153968444 no 2112 0.41210570568464 674 5457690
SGTC_661 1304-0007 33.6 µM -0.22256810349601 0.381266080770326 no 2113 0.411935831742548 647 3117130
SGTC_2822 7994718 71.43 µM -0.222607708039114 0.38124792795328 no 2114 0.411920418414153 643 1018011
SGTC_1360 1598-0022 39.8 µM -0.223797642792454 0.380702641140133 no 2115 0.411457382115858 669 761525
SGTC_1455 4262-0120 131 µM -0.224551058879768 0.380357511123953 no 2116 0.411164270926608 636 1529587
SGTC_627 1391-0720 175 µM -0.224754864096123 0.38026416698237 no 2117 0.411084990465632 663 997839
SGTC_129 0088-0017 176.636 µM -0.225545629211935 0.379902057369808 no 2118 0.410777416344334 681 182446
SGTC_3331 9141060 1.957 µM -0.225870795114468 0.379753186917853 no 2119 0.410650956491928 656 4906567 YPR165W RHO1
SGTC_2761 levamisole 97.89 µM -0.225907513104545 0.379736377468406 no 2120 0.41063667712905 664 26879 An alkaline phosphatase inhibitor.
SGTC_486 niguldipine 82 µM -0.226107987899304 0.379644604369164 no 2121 0.410558716009081 626 1236 A calcium channel blocker.
SGTC_786 4544-0069 423 µM -0.226334119676231 0.37954109418543 no 2122 0.410470781581528 640 748821 YLR208W SEC13
SGTC_1638 st008370 60.6 µM -0.226899075849806 0.379282527326892 no 2123 0.410251110339948 637 24207134
SGTC_1959 st077091 55.8 µM -0.226932206667549 0.379267365822971 no 2124 0.410238228996612 645 821356 YKL052C ASK1
SGTC_3222 9128301 49.47 µM -0.227524365999374 0.378996410009358 no 2125 0.410008012341071 651 4911358
SGTC_58 0957-0393 9 µM -0.228047041802096 0.378757297334688 no 2126 0.409804834901392 656 6997992
SGTC_704 1310-0270 142 µM -0.228233245799763 0.37867212430933 no 2127 0.40973245849721 672 5718033
SGTC_448 monastrol 171 µM -0.229331616284896 0.378169830110115 no 2128 0.409305590979508 651 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2528 xanthyletin 44.79 µM -0.230193101781319 0.377776009427297 no 2129 0.408970860962588 637 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2912 7964298 10.93 µM -0.231398052811884 0.377225389563018 no 2130 0.408502788875247 636 2975850
SGTC_657 3534-0529 86.7 µM -0.231831143238666 0.377027543506314 no 2131 0.408334583560904 669 1049549
SGTC_2419 paclitaxel 166.5 µM -0.232488503194154 0.376727307468473 no 2132 0.408079307869498 630 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_727 3032-0951 202 µM -0.233170140541895 0.376416061937016 no 2133 0.407814645623368 662 3652836
SGTC_1705 st027868 56.3335 µM -0.233595792992394 0.376221743568049 no 2134 0.407649397053481 658 292948
SGTC_2959 9079155 11 µM -0.233970117047049 0.376050883503326 no 2135 0.407504088984134 653 16189457
SGTC_1770 st043884 66.3 µM -0.235870491498057 0.375183833730837 no 2136 0.406766583314991 646 670149
SGTC_113 0099-0221 2.5 µM -0.235978398969717 0.375134619593534 no 2137 0.406724716001685 634 89219
SGTC_2979 9012552 45.46 µM -0.236016793513442 0.375117109207869 no 2138 0.406709819455402 652 17100905
SGTC_658 3253-0951 102 µM -0.236278919623061 0.374997569691665 no 2139 0.406608121796678 656 1184878
SGTC_2937 9044753 11.33 µM -0.236373384751865 0.374954492928067 no 2140 0.406571473490894 625 6465530 YGL099W LSG1
SGTC_2185 6113692 200 µM -0.236379860096172 0.37495154018261 no 2141 0.406568961372713 651 874150
SGTC_77 0828-0286 12.516 µM -0.237758501790805 0.374323049188845 no 2142 0.406034203265846 650 745345
SGTC_2006 4011487 200 µM -0.237872854499812 0.374270933393162 no 2143 0.405989855118758 650 45595294
SGTC_3318 9139014 38.6185 µM -0.238362226434685 0.374047930029966 no 2144 0.405800081044988 658 16643984
SGTC_3298 9116858 71.43 µM -0.238451995980606 0.374007027249065 no 2145 0.405765271616744 691 2506942
SGTC_2704 st078022 71.1 µM -0.238859472209182 0.373821381780217 no 2146 0.405607276239166 694 54697681
SGTC_387 norethindrone acetate 66.7 µM -0.239125269817766 0.373700300616758 no 2147 0.405504223804151 686 541197
SGTC_2815 7968870 71.43 µM -0.239596933095877 0.373485470313337 no 2148 0.405321371284062 680 2977326 YHR190W ERG9
SGTC_1807 st050092 58.9 µM -0.24104145994542 0.372827770890409 no 2149 0.404761491643014 680 5008496
SGTC_458 nppb 133 µM -0.24164826341285 0.372551601011007 no 2150 0.404526360657751 650 4549 A chloride channel blocker.
SGTC_2734 clemastine 41.6 µM -0.242123436916746 0.372335384611856 no 2151 0.404342259185655 669 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3120 9124077 49.47 µM -0.242265013494114 0.372270971335187 no 2152 0.404287410775655 652 18774327 YGL155W CDC43
SGTC_2131 toluylene red 5.2905 µM -0.242539065897714 0.372146295517073 no 2153 0.404181245038452 647 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_762 1165-0429 115 µM -0.244777418367857 0.371128495192045 no 2154 0.403314389820562 642 5967793
SGTC_3074 9116018 49.47 µM -0.245361285540359 0.37086315302469 no 2155 0.403088351290346 651 17027303
SGTC_2875 9039966 71.43 µM -0.245689095190461 0.37071420473854 no 2156 0.402961457142435 670 6463691
SGTC_3304 9125678 46.087 µM -0.246153046446596 0.370503430321296 no 2157 0.402781880450983 653 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2995 9067767 71.4286 µM -0.246153305673606 0.370503312564563 no 2158 0.402781780120463 672 11673567
SGTC_840 0245-0196 390 µM -0.247201716768462 0.370027159612616 no 2159 0.402376058370162 632 3827528
SGTC_1753 st043925 64 µM -0.248509154335326 0.369433644670548 no 2160 0.401870244029499 678 670181
SGTC_809 3998-0021 90 µM -0.24960846351125 0.368934850820302 no 2161 0.401445076399782 683 715485
SGTC_1710 st031758 61.5 µM -0.250063651713631 0.368728381048215 no 2162 0.401269062424676 645 5394341
SGTC_654 1124-0271 80.9 µM -0.250156033767686 0.368686481901244 no 2163 0.401233342210951 663 5403748
SGTC_1289 0976-0073 69.1 µM -0.250304236775319 0.36861926886489 no 2164 0.401176040131554 680 3391136
SGTC_825 1988-2224 89.6 µM -0.250459404321968 0.368548901577234 no 2165 0.401116047519808 667 1180859
SGTC_124 0136-0217 7.121 µM -0.251072806687936 0.368270771502417 no 2166 0.400878909877668 679 3976905
SGTC_1829 berberine 14.4 µM -0.251972685800499 0.367862871525146 no 2167 0.400531088166529 671 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_153 4077-0274 519.67 µM -0.252035048312047 0.367834609168159 no 2168 0.400506986697107 627 3121976
SGTC_278 4092-0821 23.9 µM -0.25324875064903 0.367284708404714 no 2169 0.400037998222258 684 877900
SGTC_2146 5545642 200 µM -0.253588120221755 0.367130996443048 no 2170 0.399906887692091 661 825326
SGTC_2251 lansoprazole 556 µM -0.253610939737376 0.367120661476153 no 2171 0.399898072106683 693 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1190 1486-1332 13 µM -0.254268379402684 0.3668229481879 no 2172 0.399644113377408 667 4150046
SGTC_3006 9075424 71.4286 µM -0.25547554070041 0.366276509013105 no 2173 0.399177916327134 659 7465181
SGTC_677 0929-0063 136 µM -0.255993848387305 0.366041972580892 no 2174 0.398977793683775 657 1539583
SGTC_2722 naftopidil 47.16 µM -0.256443665711158 0.365838468887222 no 2175 0.398804137222599 688 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3191 9110352 49.47 µM -0.256810812858347 0.365672394319815 no 2176 0.398662411252476 651 17122424
SGTC_451 chloral hydrate 100 µM -0.257320400803382 0.365441930106219 no 2177 0.398465722500164 692 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1515 3460-0031 42.1 µM -0.257699445880669 0.365270536187372 no 2178 0.39831943689416 652 2876596
SGTC_2173 5763948 167 µM -0.259173185265135 0.364604407102344 no 2179 0.39775080973304 639 2867177
SGTC_2823 7987624 58.44 µM -0.261484871914828 0.36356035025781 no 2180 0.39685930713982 714 2239440
SGTC_2235 salicylic acid 500 µM -0.261712820835984 0.363457453467016 no 2181 0.396771427683541 654 338 A COX inhibitor and kinase inhibitor.
SGTC_2807 7945238 51.95 µM -0.261922032192548 0.36336302353501 no 2182 0.396690776595202 696 17148797
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.2619793572003 0.363337150687877 no 2183 0.396668678545686 653 16623 A steroid.
SGTC_2054 5233173 129 µM -0.262336342006245 0.363176044581835 no 2184 0.396531072988214 651 6889
SGTC_3037 9091026 49.47 µM -0.262659749521613 0.363030112695839 no 2185 0.396406421464204 675 25236398 YIL048W NEO1
SGTC_1283 0922-0125 16.4 µM -0.263328698917513 0.362728324309959 no 2186 0.396148620743958 646 3360884
SGTC_2958 9077254 16.72 µM -0.263491682433701 0.362654809186804 no 2187 0.396085816787683 662 16457351
SGTC_1643 st009866 20.2 µM -0.26397871729626 0.362435158082616 no 2188 0.395898159185625 656 3156273 YOR207C RET1
SGTC_851 0394-0702 453 µM -0.264974995536894 0.361985981011762 no 2189 0.395514362095737 655 762646
SGTC_110 0850-0284 111.64 µM -0.266080686439382 0.361487697177785 no 2190 0.395088534494699 638 3906265
SGTC_1070 indatraline 8.81 µM -0.266287394476615 0.361394569439576 no 2191 0.395008940245584 683 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1548 st061468 90.8 µM -0.266979541750086 0.361082797593092 no 2192 0.394742456432996 667 390799
SGTC_2023 5144124 124 µM -0.267832047301038 0.360698920543063 no 2193 0.394414300720248 664 2830192
SGTC_2473 5854593 8.94 µM -0.267861675206154 0.360685581833762 no 2194 0.394402897370453 661 2872951
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.267993158956123 0.360626388890009 no 2195 0.394352292279381 644 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2749 bexarotene 57.39 µM -0.269010334825223 0.360168577302035 no 2196 0.393960864845902 672 82146 An retinoic acid receptor inhibitor.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.269430249553285 0.359979640059218 no 2197 0.393799305371187 683 165521
SGTC_339 3091-4833 71.4 µM -0.270363478232758 0.359559863881449 no 2198 0.393440317161212 661 3240077
SGTC_463 ikarugamyin 104 µM -0.270386811358006 0.359549370562417 no 2199 0.393431342688852 672 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2229 7354935 190 µM -0.270391448539412 0.359547285152552 no 2200 0.393429559125846 688 318112
SGTC_1888 azatryptophan 97.5 µM -0.272341705683991 0.358670596834865 no 2201 0.392679645584052 669 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1496 4469-0713 57.4 µM -0.27341720562187 0.358187451315528 no 2202 0.392266264158842 698 746691
SGTC_1762 st045503 25.4615 µM -0.273650158009258 0.358082832281454 no 2203 0.392176742086442 686 4645554
SGTC_1731 st035964 63 µM -0.273966604355773 0.357940733138728 no 2204 0.392055142975999 705 6739575
SGTC_529 4076-0302 30.3 µM -0.273971596655374 0.357938491521421 no 2205 0.392053224696714 669 5816522
SGTC_2513 baicalein 25.65 µM -0.274070878344561 0.357893913573129 no 2206 0.392015076488024 697 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3218 9131285 49.47 µM -0.275027940407217 0.357464287636558 no 2207 0.391647386197119 703 17156417
SGTC_31 0508-1974 57.237 µM -0.275511098772582 0.35724746601152 no 2208 0.391461800030901 650 6810525
SGTC_1952 st077036 64.1 µM -0.27605984765447 0.357001265951935 no 2209 0.391251049826151 684 2937007
SGTC_2971 9092186 9.93 µM -0.278017012962736 0.356123655408647 no 2210 0.390499649469657 636 25236400
SGTC_3082 9117008 49.47 µM -0.278290831645667 0.356000933275597 no 2211 0.390394556770701 653 41448529
SGTC_1153 4055-0057 267 µM -0.28064227040608 0.354947662939507 no 2212 0.389492395644644 653 882706
SGTC_1082 camptothecin 424.86 nM -0.280773141645241 0.354889074785636 no 2213 0.389442202573574 634 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2264 7948757 110.76 µM -0.281007598539675 0.354784122210451 no 2214 0.38935228588882 647 2971411
SGTC_2267 7931562 200 µM -0.28153542822896 0.354547884217078 no 2215 0.389149879339035 657 934880
SGTC_808 0711-0032 135 µM -0.284383130338315 0.353274320022133 no 2216 0.388058392793079 702 4252555
SGTC_2854 9024559 71.43 µM -0.284469304879761 0.353235806110332 no 2217 0.388025376963816 697 3163529
SGTC_1901 st060216 58.6 µM -0.285213993640524 0.352903045675258 no 2218 0.38774010002509 654 688792
SGTC_1768 st044301 37.178 µM -0.285247559389312 0.352888049636274 no 2219 0.387727243013204 694 3931349
SGTC_1433 4060-0023 7.6 µM -0.285955426615468 0.352571851811199 no 2220 0.387456130507848 657 3840627
SGTC_264 promethazine 12.5 mM -0.286987989485168 0.352110798074869 no 2221 0.387060758299832 659 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_980 1473-0395 201 µM -0.288658373720965 0.351365408538114 no 2222 0.386421410094331 667 768876
SGTC_134 0269-0018 6.916 µM -0.288924000021769 0.351246928464664 no 2223 0.386319768613665 652 4378915
SGTC_3137 9097352 49.47 µM -0.289160297440328 0.351141542407724 no 2224 0.386229356338762 704 44120435
SGTC_3046 9092212 49.47 µM -0.289448127475736 0.351013188832733 no 2225 0.386119234965471 652 25236637
SGTC_319 1348-1596 45.5 µM -0.290319975957075 0.350624504581687 no 2226 0.385785729015915 710 5380505
SGTC_3192 9110362 49.47 µM -0.29055957586258 0.350517714407551 no 2227 0.385694090257889 653 16649480
SGTC_1840 st055363 71 µM -0.290971234433071 0.350334264917378 no 2228 0.385536659851992 689 676033
SGTC_1122 capsaicin 818.572 nM -0.291590889303218 0.350058190818514 no 2229 0.385299721074334 711 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2576 guaiol 23.12 µM -0.293962374620853 0.349002358732765 no 2230 0.384393327220747 668 227829
SGTC_1355 1499-0035 1.68 µM -0.294002815817832 0.348984363619161 no 2231 0.384377875852235 682 1548538
SGTC_2785 7756463 72.73 µM -0.294200233476983 0.348896523587967 no 2232 0.384302451123117 670 2201551
SGTC_2691 st077356 60.2 µM -0.294278868366572 0.348861537629516 no 2233 0.384272409360563 690 2839272
SGTC_1182 1222-0449 220 µM -0.294625909491708 0.348707148666011 no 2234 0.38413983368129 666 658318
SGTC_2826 7992541 19.48 µM -0.29506326467354 0.348512617166237 no 2235 0.383972775785736 713 2985066
SGTC_3121 9125696 49.47 µM -0.295723078763673 0.348219213410636 no 2236 0.383720785383351 684 1235365
SGTC_2485 5633444 17.78 µM -0.296167315786975 0.348021722833977 no 2237 0.383551153968436 658 5724239
SGTC_1331 1472-0049 76.2 µM -0.29762893195018 0.347372236021589 no 2238 0.382993195125645 664 24051409
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.298389551279322 0.347034422689064 no 2239 0.382702931460818 691 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2397 5161689 200 µM -0.299224542997802 0.346663718333056 no 2240 0.382384362037315 699 2259942
SGTC_1884 5633444 25 µM -0.302226056134954 0.345332375648213 no 2241 0.381239871247508 671 5724239
SGTC_1208 2323-2347 50.3 µM -0.302489376603673 0.345215668934164 no 2242 0.381139515316925 699 5412760
SGTC_1573 oleylamine 1.06 µM -0.303118371932202 0.344936950428479 no 2243 0.380899826810961 706 5356789 An amine of the fatty acid oleic acid.
SGTC_1430 4049-0248 69.1 µM -0.303162131276667 0.344917563048153 no 2244 0.380883153327539 705 22774488
SGTC_1655 st012546 55.1 µM -0.303303087849783 0.344855115642089 no 2245 0.380829446598097 691 720985 YLR208W SEC13
SGTC_570 0987-0065 62.6 µM -0.303840173458543 0.344617211574784 no 2246 0.380624829362459 655 3104428
SGTC_245 methotrexate 289.6 µM -0.30441844743855 0.34436113165607 no 2247 0.380404557635748 681 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1574 spiramycin 23.7 µM -0.305033681277842 0.344088762936032 no 2248 0.380170250011068 662 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_14 0354-0009 295 µM -0.307848274509439 0.342843754078514 no 2249 0.379098893211605 682 1713507
SGTC_586 0957-0265 8.15 µM -0.308427969333925 0.342587542792685 no 2250 0.378878351090201 688 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1559 coumarin 343 70.1 µM -0.308797037128466 0.342424461344879 no 2251 0.3787379615519 702 108770 A hepatotoxic, DNA x-linker.
SGTC_2833 9001315 45.46 µM -0.309063199405636 0.342306869394341 no 2252 0.378636726127158 665 2989378
SGTC_775 4577-0580 57.3 µM -0.309351399464948 0.34217955826956 no 2253 0.378527117972449 716 2006902
SGTC_1680 diphenhydramine 100 µM -0.30989488903142 0.341939522928909 no 2254 0.378320444789475 704 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_408 cantharidin 100 µM -0.310317782370143 0.341752793797123 no 2255 0.378159654899212 666 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_714 4296-0578 26.1 µM -0.310427013675674 0.341704568854065 no 2256 0.378118127075373 672 1589775
SGTC_385 1494-0393 12.4 µM -0.31065635006306 0.341603326669923 no 2257 0.37803094199122 699 3090647
SGTC_736 0958-0254 92.6 µM -0.311448744457229 0.341253606250026 no 2258 0.377729751224677 726 6812352
SGTC_615 k087-0205 167 µM -0.311681317044121 0.341150987033757 no 2259 0.377641363998534 671 9642773
SGTC_3307 9126885 69.2785 µM -0.312702606664862 0.340700497232673 no 2260 0.377253307494184 689 24824909
SGTC_1440 4100-1550 40 µM -0.313136238533616 0.340509291310695 no 2261 0.377088579083372 696 742806
SGTC_121 0557-0495 61.343 µM -0.316272903453116 0.339127431314173 no 2262 0.375897688136473 699 3104427
SGTC_1683 st010134 710 nM -0.316518210176801 0.339019452147171 no 2263 0.375804602699245 723 3818134
SGTC_2680 butyl paraben 22.24 µM -0.317583699728771 0.338550598276385 no 2264 0.375400370114967 684 7184 An antifungal and steroid mimetic.
SGTC_1863 st057641 20.1 µM -0.317694993943682 0.338501639219319 no 2265 0.375358154449638 680 3921635
SGTC_333 3486-0131 40.1 µM -0.317828420371393 0.338442947654024 no 2266 0.375307545651496 671 6744690
SGTC_3250 9135583 49.47 µM -0.319497897543883 0.337708910829235 no 2267 0.374674492716618 671 7699353
SGTC_2567 aureobasidin a 60 nM -0.320169419019817 0.337413829639243 no 2268 0.374419952037412 672 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1152 3909-8331 15.9 µM -0.321854820378666 0.336673668115315 no 2269 0.373781340734449 684 16001939
SGTC_1432 4049-0298 68.4 µM -0.324435605709957 0.335541515378706 no 2270 0.372804133417063 703 741646
SGTC_554 4483-2211 187 µM -0.324565718734367 0.33548447611011 no 2271 0.372754888083283 675 747107
SGTC_3348 9149464 3.537 µM -0.32482581081966 0.335370467665806 no 2272 0.372656454352586 677 1951442
SGTC_2022 5136654 200 µM -0.324984661200063 0.335300844841623 no 2273 0.372596340367278 723 1713771
SGTC_2082 5219693 150 µM -0.325144850846177 0.335230640756594 no 2274 0.372535722704258 705 2834649
SGTC_2334 9017922 200 µM -0.325761772678698 0.33496032479255 no 2275 0.372302301666972 676 3163164
SGTC_1155 4088-0394 48.2 µM -0.326019606600938 0.334847375303614 no 2276 0.372204760476134 686 2326248
SGTC_3138 9097216 49.47 µM -0.328559654249767 0.333735454705346 no 2277 0.37124427381481 703 25237486
SGTC_3245 9134821 49.47 µM -0.329804929343456 0.333190860489208 no 2278 0.37077368125703 699 17014901
SGTC_1558 st069300 45.6 µM -0.330461643764301 0.332903802090687 no 2279 0.370525585023368 705 24208000
SGTC_2984 9022109 38.96 µM -0.330683790560711 0.332806720994378 no 2280 0.370441673687775 707 6459207
SGTC_3035 9091303 49.47 µM -0.331063965797126 0.332640605380401 no 2281 0.370298084696006 691 25237002
SGTC_2649 anisomycin 9.56 µM -0.33128446767601 0.332544273270587 no 2282 0.370214811268567 707 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2690 usnic acid 100 µM -0.331558437399766 0.332424597716065 no 2283 0.370111353967506 736 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3036 9090181 49.47 µM -0.332161270086698 0.332161328278546 no 2284 0.369883743506711 676 25236586
SGTC_1202 1988-0068 29.6 µM -0.332941110946571 0.331820878600772 no 2285 0.369589368004685 685 2850480
SGTC_1446 4239-0190 62 µM -0.333332383912273 0.331650115579986 no 2286 0.369441698477405 707 1340085
SGTC_3077 9117319 49.47 µM -0.333461902243287 0.331593597678115 no 2287 0.369392821471352 709 17154678
SGTC_1425 4048-4433 7.33 µM -0.334180265366293 0.331280195260942 no 2288 0.369121767387265 713 23734946
SGTC_674 0498-0004 451 µM -0.33424354913447 0.331252591921852 no 2289 0.369097892156866 697 4231473
SGTC_1396 3511-0007 98.6 µM -0.334351353132018 0.331205571702113 no 2290 0.369057221827668 708 X1396
SGTC_511 blebbistatin 171 µM -0.334466603079583 0.331155306770635 no 2291 0.369013744047325 699 3476986 A myosin inhibitor.
SGTC_484 loperamide 105 µM -0.334534080469993 0.331125878699412 no 2292 0.36898828913324 672 3955 An opioid-receptor agonist.
SGTC_2962 9082311 13.18 µM -0.335504766504806 0.330702661033584 no 2293 0.368622174862876 684 16459453
SGTC_2885 9057732 51.95 µM -0.335562138399848 0.330677653738783 no 2294 0.36860053959689 701 6471414
SGTC_3066 9117245 49.47 µM -0.337872651969071 0.329671174900721 no 2295 0.367729578709347 707 17176980
SGTC_1127 asiatic acid 681.4 nM -0.338447996853448 0.329420741257231 no 2296 0.3675128048013 690 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_96 0929-0093 37.281 µM -0.338822553321777 0.329257747032604 no 2297 0.367371705047824 689 6991579
SGTC_767 0929-0023 86 µM -0.340274252824206 0.328626323633773 no 2298 0.366825002399652 675 1204563
SGTC_2694 st077685 81.9 µM -0.341913991265741 0.327913699937114 no 2299 0.366207810010611 667 2838096
SGTC_1663 st014140 55.4 µM -0.342496731748727 0.327660593936175 no 2300 0.365988551566057 696 4207120
SGTC_2128 5255449 168.493 µM -0.342523489588827 0.32764897390502 no 2301 0.365978484871593 676 736008
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.34313363872123 0.327384051950055 no 2302 0.365748962811442 693 16725076
SGTC_36 0335-0881 14.2 µM -0.344731858298264 0.326690529832519 no 2303 0.365147982587043 699 23828853
SGTC_1945 st075991 56.6 µM -0.345330656252978 0.326430844899328 no 2304 0.364922901121381 689 1084980
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.345695216431013 0.326272784694391 no 2305 0.36478588980789 678 6708561
SGTC_1412 3909-8563 178 µM -0.345981359087592 0.326148745362491 no 2306 0.364678361957347 700 23767530
SGTC_70 0141-0289 43.283 µM -0.346271384565729 0.326023042498826 no 2307 0.36456938586675 673 352408
SGTC_663 1486-0733 13.9 µM -0.346481824402654 0.325931846024391 no 2308 0.364490320661809 709 722445 YPR165W RHO1
SGTC_2950 9072895 21.46 µM -0.346820281474235 0.325785193680835 no 2309 0.364363169675218 708 17332245
SGTC_1752 st044819 83.042 µM -0.347173229604351 0.325632291117892 no 2310 0.36423059060895 681 441209 YML126C ERG13
SGTC_1067 clotrimazole 1.36 µM -0.34773582874461 0.325388625161174 no 2311 0.364019293234642 684 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1546 5-methoxyflavanone 78.7 µM -0.349244368490756 0.324735633673889 no 2312 0.36345292972488 691 147795
SGTC_2487 5918373 44.05 µM -0.349321898273806 0.324702088402412 no 2313 0.363423830129404 707 2876279
SGTC_413 propylparaben 100 µM -0.349457583664207 0.324643384020675 no 2314 0.363372904629904 715 7175 A pharmaceutical preservative.
SGTC_2051 5263410 176 µM -0.349737271709561 0.324522390531588 no 2315 0.36326793961098 691 227584
SGTC_3026 9090633 49.47 µM -0.349785746711313 0.324501422052134 no 2316 0.363249748316628 687 25236842
SGTC_1235 benzylparaben 21.5 µM -0.351180763076285 0.323898228562407 no 2317 0.362726370521432 715 7180
SGTC_2683 piperine 63.03 µM -0.352945222130179 0.323135953165875 no 2318 0.362064753669334 720 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1354 1498-1681 81 µM -0.353321726718275 0.322973392940338 no 2319 0.361923629509431 710 5754243
SGTC_2701 st077767 14.721 µM -0.354662907850381 0.322394597335039 no 2320 0.361421071001191 705 5721188
SGTC_2635 hydroquinidine 100 µM -0.354994508390838 0.322251559211781 no 2321 0.361296852662907 687 442912 An experimental heart treatment.
SGTC_1591 genipin 88.4 µM -0.356345055304222 0.321669263767859 no 2322 0.360791085801973 707 442424 A DNA cross-linking agent.
SGTC_2214 7179297 48.276 µM -0.35698578544347 0.321393162607487 no 2323 0.36055122357374 676 769744
SGTC_247 mechlorethamine 29.705 µM -0.357341487478238 0.321239927325998 no 2324 0.360418087471514 687 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3213 9129884 49.47 µM -0.357448550927636 0.321193810696058 no 2325 0.360378017888816 717 17190742
SGTC_1597 7-benzyloxygramine 47.5 µM -0.357556650374961 0.321147250616517 no 2326 0.36033756212913 711 260807
SGTC_2366 9070441 60.58 µM -0.35806392571998 0.320928796955511 no 2327 0.3601477373751 715 6837235
SGTC_2568 diosmetin 100 µM -0.359067540020861 0.320496781949949 no 2328 0.359772281932817 742 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2240 6690706 185.951 µM -0.359474677025242 0.32032159535912 no 2329 0.359620009179123 669 805876
SGTC_1511 0906-3109 28.5 µM -0.359524287811785 0.32030025111715 no 2330 0.359601455839462 693 2882180
SGTC_2294 7971431 200 µM -0.359708432508259 0.320221031026137 no 2331 0.359532592679621 748 5741572
SGTC_2534 helenine 20.12 µM -0.36014911853545 0.320031478675742 no 2332 0.359367811276919 689 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1467 k284-1082 293 µM -0.360514874831177 0.319874191529131 no 2333 0.359231067471598 726 3334705
SGTC_834 0312-0008 75.7 µM -0.363629270382265 0.318536213808584 no 2334 0.358067433186865 716 6385573 YIL048W NEO1
SGTC_1682 st012968 530 nM -0.364393884301485 0.318208088067217 no 2335 0.35778195082222 690 24207270
SGTC_827 3253-0474 693 µM -0.364448920296107 0.318184475467877 no 2336 0.357761405209888 727 5402065
SGTC_2511 berberine 10.47 µM -0.364660474903721 0.318093717126759 no 2337 0.357682433115174 702 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_316 k060-0003 58.6 µM -0.365215292987139 0.317855748352405 no 2338 0.357475351724324 704 6152314
SGTC_3052 9092717 49.47 µM -0.365756869142279 0.317623531745178 no 2339 0.357273253242493 723 25237534
SGTC_3248 9135562 49.47 µM -0.366359033548211 0.317365420374722 no 2340 0.357048592208784 696 17650701
SGTC_1378 2093-0007 380 nM -0.368505668899652 0.316446011072291 no 2341 0.356248109463855 731 3618014
SGTC_75 0159-0059 199.013 µM -0.369483830031114 0.316027437692586 no 2342 0.355883561809327 748 5377270
SGTC_2340 7987427 183.45 µM -0.369696181791988 0.315936599539707 no 2343 0.355804438522561 719 2239331
SGTC_3083 9117465 49.47 µM -0.370312409360622 0.315673057528737 no 2344 0.355574864345544 748 16420915
SGTC_2480 5767542 37.17 µM -0.370646600604471 0.315530173155375 no 2345 0.355450384060979 679 2867358
SGTC_3102 9121669 49.47 µM -0.370950471315581 0.315400276343012 no 2346 0.355337211017581 695 41905072
SGTC_1089 terbinafine 2.25 µM -0.371503433460108 0.315163957965774 no 2347 0.355131299556637 711 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_191 3914-0123 66.505 µM -0.371817419407912 0.315029804044387 no 2348 0.355014396623441 734 3144412
SGTC_3094 9117742 49.47 µM -0.372477208684335 0.314747981389391 no 2349 0.354768789022221 735 17149698
SGTC_351 caspofungin 25 nM -0.373035839856272 0.314509451763412 no 2350 0.354560884863519 682 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_334 1502-1024 68.5 µM -0.373942145720431 0.314122633396534 no 2351 0.354223679790364 732 3296216
SGTC_3099 9120367 49.47 µM -0.374206706552664 0.314009755249601 no 2352 0.354125267387593 715 24824940
SGTC_1645 Cervolide 78 µM -0.374894284812392 0.313716472884804 no 2353 0.353869544837426 700 23173 A fragrance.
SGTC_379 3970-0972 5.9 µM -0.375876237174689 0.313297831089496 no 2354 0.353504453638854 699 2898042 YBL034C STU1
SGTC_3258 9138477 49.47 µM -0.375943059648314 0.313269350986181 no 2355 0.353479613846686 699 4970355
SGTC_599 1935-0052 86.5 µM -0.377160643618294 0.312750605205723 no 2356 0.353027113021361 715 9557311
SGTC_482 fipronil 114 µM -0.378440334435149 0.312205798547571 no 2357 0.352551754841875 686 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2058 5236698 133 µM -0.378498894316758 0.312180877482392 no 2358 0.352530007496679 686 766665
SGTC_1011 4112-3381 17.4 µM -0.378575250618716 0.312148384165559 no 2359 0.352501651830438 741 2877139
SGTC_1414 3917-0015 5.4 µM -0.379082551395282 0.31193254014985 no 2360 0.352313281500592 733 6618702
SGTC_3080 9117754 49.47 µM -0.379798955328989 0.311627837860316 no 2361 0.352047328935292 744 9550191
SGTC_2144 5628481 200 µM -0.380192070673843 0.311460692065147 no 2362 0.35190142240204 695 2818399
SGTC_876 0720-0963 56.8 µM -0.381101909774772 0.311073993390854 no 2363 0.351563815183835 755 765861
SGTC_1819 st053448 58.6 µM -0.381435825992233 0.31093212501133 no 2364 0.351439940727528 723 2857616
SGTC_260 nsc-65238 3.989 µM -0.381540758893994 0.310887548788426 no 2365 0.351401016536961 701 3246252
SGTC_1815 st051655 58.2 µM -0.381777530077481 0.31078697694683 no 2366 0.351313193502497 708 5984156
SGTC_248 streptozotocin 5.23457 mM -0.382155472531327 0.310626469942655 no 2367 0.351173023750387 737 5300 DNA alkylating agent.
SGTC_1700 st030840 7.9285 µM -0.382489136715168 0.310484797268534 no 2368 0.351049292566546 697 5499307
SGTC_1961 st076550 68.7 µM -0.383593090114902 0.310016262852541 no 2369 0.350640031117416 711 1579337
SGTC_3023 9089636 49.47 µM -0.383791517804241 0.309932079828448 no 2370 0.350566487672297 720 17249241
SGTC_3106 9121286 49.47 µM -0.383803807997277 0.309926866036943 no 2371 0.350561932730403 695 15943471
SGTC_106 0092-0003 11.579 µM -0.383939495053073 0.309869306909169 no 2372 0.350511646367877 721 1072148
SGTC_837 0091-0265 12.5 µM -0.3843668545279 0.309688049342679 no 2373 0.35035328173931 715 759367
SGTC_2165 5727197 32.143 µM -0.384417221750986 0.309666689951777 no 2374 0.350334619102844 720 1361712
SGTC_2601 securinine 100 µM -0.384851568755783 0.309482521691339 no 2375 0.350173694907788 712 442872 A GABA receptor antagonist.
SGTC_374 0880-0231 82.3 µM -0.384928432089925 0.309449935710209 no 2376 0.350145220085339 719 6833587
SGTC_419 nsc-638432 893 µM -0.386736054661637 0.308684031889238 no 2377 0.349475810669022 716 368090
SGTC_1718 roemerine 11.9335 µM -0.387202675197604 0.308486456007691 no 2378 0.349303084900298 717 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2459 5811157 9.22 µM -0.387314929353204 0.308438933765603 no 2379 0.349261537193714 705 2870684 YBR192W RIM2
SGTC_382 3229-0966 23.2 µM -0.388463607596605 0.307952831068634 no 2380 0.348836490264473 753 5722370
SGTC_2210 7115885 190.385 µM -0.38899739051086 0.307727057032391 no 2381 0.348639038369491 731 2927039
SGTC_1712 st032288 53.4 µM -0.389184458910591 0.307647949975095 no 2382 0.348569849506125 719 2883011
SGTC_2191 5911152 200 µM -0.389281238044266 0.30760702774605 no 2383 0.348534056884542 704 2875902
SGTC_2570 licareol 100 µM -0.390789125897952 0.306969739741886 no 2384 0.347976556695122 728 443158
SGTC_1133 3473-0247 50 µM -0.393425076886512 0.30585709200031 no 2385 0.347002775595514 729 711311
SGTC_2797 7859098 81.82 µM -0.393556145457769 0.305801813938905 no 2386 0.346954382136192 706 972681
SGTC_1114 scopoletin 1.73284 µM -0.394772452422935 0.305289048643825 no 2387 0.346505413453372 726 5280460 A coumarin with genotoxic properties.
SGTC_923 1900-2434 73.3 µM -0.395212730419106 0.305103532274339 no 2388 0.346342949163462 760 5910570
SGTC_1116 jasmonic acid 1.58368 µM -0.395781404581096 0.304863988755775 no 2389 0.346133148027584 734 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1160 4092-0570 10.5 µM -0.395985634361604 0.3047779811225 no 2390 0.346057812991002 714 4994975
SGTC_1696 st025591 34.7925 µM -0.396373865873762 0.304614514275705 no 2391 0.345914621317515 713 2787147
SGTC_1461 k072-0203 53.8 µM -0.397735394350613 0.304041544262694 no 2392 0.345412622160834 721 5418714
SGTC_3221 9128209 49.47 µM -0.399394592686996 0.303343956491266 no 2393 0.344801238809862 719 16460723
SGTC_2688 kanamycin b 96.69 µM -0.39951069186943 0.30329517092836 no 2394 0.344758473591959 727 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2512 diallyl trisulfide 49.23 µM -0.400027818679586 0.303077913799099 no 2395 0.344568013657642 735 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.400229847259582 0.302993055759876 no 2396 0.344493616398892 706 676296 Flavone; oxidizing agent.
SGTC_332 4112-0506 40.9 µM -0.400342664351939 0.302945673837476 no 2397 0.344452073991156 719 2790355
SGTC_1817 st052116 64.4 µM -0.40128476896908 0.302550129940731 no 2398 0.34410523802611 710 4361398
SGTC_1180 1193-0155 285 µM -0.402167303621462 0.302179806713665 no 2399 0.343780451673476 736 2921347
SGTC_3097 9117246 49.47 µM -0.40355995524542 0.301595845888342 no 2400 0.343268168933487 687 16423892
SGTC_1395 3486-0190 4.35 µM -0.405740774853009 0.300682415167208 no 2401 0.342466539543335 745 6748079
SGTC_2036 5160441 105 µM -0.406841808310518 0.300221724947487 no 2402 0.342062088927397 722 134534 YIL048W NEO1
SGTC_79 0052-0007 94.094 µM -0.407221510704798 0.300062925353206 no 2403 0.34192265207207 718 2801472
SGTC_1034 k072-0165 12.7 µM -0.409383736966168 0.299159361655879 no 2404 0.341129036296225 748 5835461
SGTC_1213 1315-0166 115 µM -0.410965627949833 0.298499095086684 no 2405 0.340548869303548 707 768401
SGTC_3212 9128307 49.47 µM -0.411396066656981 0.29831954878684 no 2406 0.340391068807244 726 27243542
SGTC_2471 5466956 24.79 µM -0.41228112326563 0.297950525031595 no 2407 0.340066691446058 732 724419
SGTC_3182 9108849 49.47 µM -0.412329187331651 0.297930490710186 no 2408 0.340049079128369 710 17133045
SGTC_2018 5133068 143 µM -0.414229635449911 0.297138828470446 no 2409 0.3393529700324 753 785362
SGTC_1077 5-fluorocytosine 377 nM -0.414528140306876 0.297014568915455 no 2410 0.339243681361728 753 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_474 dl-dihydrosphingosine 5 µM -0.414720835818957 0.296934367574907 no 2411 0.339173138815673 708 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3256 9138902 49.47 µM -0.41562961845198 0.296556258944959 no 2412 0.338840524987561 744 17228773
SGTC_2244 6635614 200 µM -0.416796833757594 0.296070950533353 no 2413 0.338413509277059 696 836499
SGTC_656 4090-1979 187 µM -0.418205306140217 0.295485817281861 no 2414 0.337898508295649 739 22330961
SGTC_271 rotenone 740 µM -0.41873463196227 0.295266052684613 no 2415 0.337705041274882 760 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1662 st014054 52 µM -0.420337035141317 0.294601228670965 no 2416 0.337119629206829 723 2838777
SGTC_2135 5326629 150.42 µM -0.422550278897044 0.293684109301398 no 2417 0.336311704877676 708 5020077
SGTC_497 capsazepine 133 µM -0.422668892795648 0.293634995649292 no 2418 0.336268427255009 707 2733484 A calcium channel blocker.
SGTC_2626 ethyl orsellinate 100 µM -0.424728852424231 0.292782649221026 no 2419 0.335517174150561 726 75653 A natural product.
SGTC_735 3076-0345 636 µM -0.424770472487079 0.292765439995313 no 2420 0.335502002362421 702 2888990
SGTC_597 k018-0003 82.8 µM -0.425361096640688 0.292521277061884 no 2421 0.335286730682172 763 6786234
SGTC_204 PMA1.184 62.41 µM -0.426359941538982 0.292108571919966 no 2422 0.334922793108679 733 2252213 YGL008C PMA1
SGTC_66 0109-0187 42.4 µM -0.426842725371118 0.291909191326464 no 2423 0.334746942273031 705 759417
SGTC_1038 k292-0204 154 µM -0.42861217112622 0.29117898608767 no 2424 0.334102743315257 745 4454212
SGTC_1318 1280-3875 124 µM -0.429016438196283 0.291012275119125 no 2425 0.333955631001919 748 373245
SGTC_1605 st000082 49.1 µM -0.431283381688024 0.290078263960583 no 2426 0.333131166123613 740 1114022
SGTC_3225 9130819 49.47 µM -0.431318779894272 0.290063690571911 no 2427 0.333118298526451 769 4547121
SGTC_523 1934-0222 13.7 µM -0.432170123901278 0.289713296939504 no 2428 0.332808885793248 758 1361595
SGTC_1457 k015-0032 57.3 µM -0.432665488794232 0.289509507589138 no 2429 0.332628902590703 757 4302660
SGTC_1776 st049249 45.9 µM -0.433934918380136 0.288987581443948 no 2430 0.332167851062016 721 1822314
SGTC_2067 5224629 34.075 µM -0.434069658887342 0.288932208863076 no 2431 0.332118928766541 736 2835000
SGTC_2654 protoveratrine a 100 µM -0.435374701867023 0.288396150590075 no 2432 0.331645235035401 744 5702278 A heart drug and vasodilator.
SGTC_1337 1486-1011 40.3 µM -0.435575647901807 0.288313651850496 no 2433 0.331572321190318 722 X1337
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.435799663921762 0.288221694809136 no 2434 0.331491043857765 732 75037 A free radical scavenger.
SGTC_2434 5670830 169.91 µM -0.436616052415134 0.287886690058634 no 2435 0.331194909538401 754 1549830
SGTC_2816 7982706 58.44 µM -0.436957952557948 0.287746446097219 no 2436 0.331070921048932 741 2981853
SGTC_1375 2910-0797 186 µM -0.438745511365104 0.287013733711072 no 2437 0.330422973038237 750 742508
SGTC_878 0828-0289 13.7 µM -0.440894337884465 0.286134110713618 no 2438 0.329644746473781 716 745350 YLR208W SEC13
SGTC_2083 5306046 65.942 µM -0.442089487828196 0.285645430460083 no 2439 0.329212225509839 741 539837
SGTC_1519 esterone 74 µM -0.442174752770908 0.285610581988536 no 2440 0.329181377123493 719 698 A steroid.
SGTC_2945 9067681 61.76 µM -0.442527285291732 0.285466520576331 no 2441 0.329053845147371 767 16456930
SGTC_2265 7929201 200 µM -0.443093844850529 0.285235070128855 no 2442 0.328848928547309 768 1265108
SGTC_1308 1187-1617 41.4 µM -0.443824261453941 0.28493681294675 no 2443 0.328584823073861 742 2882570
SGTC_455 paf C-16 10 µM -0.444004927208929 0.284863063126271 no 2444 0.328519510795494 740 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2391 6285546 200 µM -0.445559520262536 0.284228837145234 no 2445 0.327957728241037 724 846083
SGTC_2789 5281112 71.43 µM -0.446469255394101 0.283858006682381 no 2446 0.327629158040609 737 765948
SGTC_724 3910-0327 137 µM -0.449741689259544 0.282526000304856 no 2447 0.326448353686313 782 2885483
SGTC_2975 9084847 53.72 µM -0.450442280219599 0.282241223901725 no 2448 0.326195782215684 718 27211724
SGTC_2700 st077718 96.8 µM -0.450795142678084 0.282097844603082 no 2449 0.326068601224916 720 904970
SGTC_493 zm226600 134 µM -0.452385874994667 0.281451914973926 no 2450 0.325495510432772 766 5240098 A potassium channel opener. YCR052W RSC6
SGTC_535 2293-4129 48.2 µM -0.453584502376492 0.280965674627898 no 2451 0.325063955002731 774 396118 YIL048W NEO1
SGTC_229 benomyl 22.8748 µM -0.453707258121371 0.280915899930266 no 2452 0.325019771090727 738 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1435 4092-0789 56.7 µM -0.454045591872903 0.28077873525878 no 2453 0.324898006158961 748 2248285
SGTC_223 busulfan 5 mM -0.454549612726281 0.280574459075322 no 2454 0.324716645807225 736 2478 A DNA alkylator.
SGTC_719 2810-4230 27.3 µM -0.454687343208025 0.280518650372454 no 2455 0.324667093876233 735 721079
SGTC_1786 berberine 21.6 µM -0.454855810973783 0.280450394158309 no 2456 0.324606487669902 738 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1215 3852-0577 11.2 µM -0.454949278985083 0.280412528229982 no 2457 0.324572864595937 724 2884876
SGTC_1765 st044815 90.4 µM -0.455243372904802 0.280293400523535 no 2458 0.324467080064595 737 645695
SGTC_3301 9125354 19.7965 µM -0.455849309646489 0.280048032924755 no 2459 0.32424917144165 721 41905162
SGTC_2887 9044784 58.44 µM -0.45876460019525 0.278868974888216 no 2460 0.323201609137726 737 6465546
SGTC_839 0122-0028 230 µM -0.459114743971152 0.278727525629683 no 2461 0.323075884699989 768 759448
SGTC_2224 6650123 117.647 µM -0.459148667939523 0.278713823057769 no 2462 0.323063704857855 737 2908370
SGTC_2328 6201408 200 µM -0.4598572169096 0.278427700884182 no 2463 0.32280935539792 775 2890418
SGTC_1441 4106-0040 13 µM -0.460332128888181 0.278236004808004 no 2464 0.322638921524215 737 2904180
SGTC_306 1672-3436 11.6 µM -0.460908366582065 0.278003495510109 no 2465 0.322432174448829 764 6797378
SGTC_856 0433-0016 11.3 µM -0.462049140328553 0.277543478290632 no 2466 0.322023040690392 738 3911780
SGTC_1014 4130-3005 69.3 µM -0.46256582806274 0.277335246331065 no 2467 0.321837803697234 754 743608
SGTC_3276 9139060 49.47 µM -0.463004240261681 0.277158620375805 no 2468 0.321680663870067 764 4870619
SGTC_2073 5212005 126 µM -0.463453433215939 0.276977708210701 no 2469 0.321519692983437 767 691789
SGTC_1311 1190-0148 100 µM -0.464077019855082 0.27672665497828 no 2470 0.321296282665165 743 1961333
SGTC_1610 st001799 48.1 µM -0.464923678722613 0.276385972398961 no 2471 0.320993056479051 719 621897
SGTC_611 3453-1652 23.7 µM -0.46573192436121 0.276060938763106 no 2472 0.320703699113122 760 1560575
SGTC_1254 0550-0035 264 µM -0.466192536448367 0.275875788943019 no 2473 0.320538845598562 738 15121435
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.466826267462486 0.275621151167477 no 2474 0.320312090507942 738 16486 A toxic proline analog.
SGTC_3223 9129970 49.47 µM -0.469570694792461 0.274519755809136 no 2475 0.319330882943125 726 17248386
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.471696581856145 0.273668088645451 no 2476 0.318571688638526 727 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3296 9122258 64.045 µM -0.471729017062036 0.273655104671363 no 2477 0.318560111302239 756 4730474
SGTC_2353 9059630 146.67 µM -0.471802895082457 0.273625532070402 no 2478 0.318533742138997 736 4779114
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.472049314563501 0.273526904357185 no 2479 0.318445794675381 775 229346 A bile salt which induces apoptosis.
SGTC_10 0279-0212 42.575 µM -0.4747689555592 0.27243955679616 no 2480 0.317475831325842 746 39851 YBR002C RER2
SGTC_1204 4049-0315 18.3 µM -0.475140397049501 0.272291216484329 no 2481 0.317343453275612 749 588402
SGTC_2841 9004761 38.96 µM -0.475541149519249 0.272131215446192 no 2482 0.317200655283277 722 2991039
SGTC_1732 st034308 51.822 µM -0.475946478617294 0.271969434737938 no 2483 0.31705625420437 716 830119
SGTC_518 1021-0119 62.6 µM -0.47601819438858 0.271940815501791 no 2484 0.317030707902638 766 1097762
SGTC_1021 4476-0760 85.3 µM -0.476970003878455 0.271561123821046 no 2485 0.316691740812492 740 746768
SGTC_2697 mebhydrolin 72.4 µM -0.47912483509983 0.270702504559815 no 2486 0.315924911429189 738 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1862 st057513 3.81 µM -0.480218661153402 0.270267175279469 no 2487 0.315535959443697 749 5393163
SGTC_2621 lithochol-11-enic acid 100 µM -0.480552452601337 0.270134400140631 no 2488 0.315417307696054 774 6708711
SGTC_1922 5578187 25 µM -0.481709994452315 0.269674207525265 no 2489 0.315005987598135 704 1350412
SGTC_3156 9099931 49.47 µM -0.482268290071789 0.269452391849178 no 2490 0.314807685166809 733 18111053
SGTC_777 1315-0167 517 µM -0.482853530152935 0.269219969128956 no 2491 0.314599869577201 729 4221767
SGTC_2673 kobusone 100 µM -0.482986790101691 0.269167060224801 no 2492 0.314552557894892 762 6710676 An epoxy ketone and protein crosslinker.
SGTC_1810 st050138 53 µM -0.483248939410513 0.269062992921846 no 2493 0.314459495121197 786 3444541
SGTC_2207 7258803 200 µM -0.485060039343625 0.268344579601167 no 2494 0.313816878562321 779 3666799
SGTC_78 0336-0123 156.75 µM -0.485948284899325 0.26799259008225 no 2495 0.313501916395146 743 6765896
SGTC_2699 st077704 54.6 µM -0.48595989188129 0.267987992064528 no 2496 0.313497801585439 753 645852
SGTC_877 0771-0151 33.1 µM -0.486854761076648 0.267633616059612 no 2497 0.31318062998464 754 6166523
SGTC_1688 st021091 57.6 µM -0.487479600567196 0.267386314296073 no 2498 0.312959247849857 775 3656366
SGTC_3288 9119690 36.221 µM -0.489241102540626 0.266689760283149 no 2499 0.312335506630396 782 17595618 YKL019W RAM2
SGTC_2810 7959871 45.46 µM -0.491905339864978 0.265637981657277 no 2500 0.311393131603619 747 2974535
SGTC_1280 0880-0253 10.1 µM -0.491981634688287 0.265607893254873 no 2501 0.311366163296701 772 6836607
SGTC_1565 sinapyl alcohol 95.1 µM -0.492797109716517 0.265286402235382 no 2502 0.311077976577953 760 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2655 perillic acid 100 µM -0.494492680641819 0.264618577191413 no 2503 0.310479137130961 759 5702197 An apoptosis inducer.
SGTC_1268 0828-0275 2.46 µM -0.495440311417 0.264245712033801 no 2504 0.310144672722673 758 745337
SGTC_1844 rapamycin 4 nM -0.496420479928983 0.263860325909659 no 2505 0.309798889357822 768 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_29 0299-0004 12.984 µM -0.496655407859592 0.263767998704671 no 2506 0.309716036578558 765 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3020 9089140 49.47 µM -0.496819769353714 0.263703414064606 no 2507 0.309658076435567 753 17217859
SGTC_1299 1079-1439 3.74 µM -0.497981502152797 0.263247149814605 no 2508 0.30924854007577 780 323161
SGTC_796 1234-0020 70.7 µM -0.498174397217144 0.263171430377175 no 2509 0.309180563241363 722 46495034
SGTC_307 1501-1223 22.3 µM -0.498269392178506 0.263134144943156 no 2510 0.309147089115094 765 2830329
SGTC_2895 9054447 58.44 µM -0.498422316470504 0.263074127970927 no 2511 0.309093205300544 751 2697450
SGTC_1575 cyproterone acetate 48 µM -0.498553224722039 0.2630227570156 no 2512 0.309047082235768 781 9880 An androgen receptor antagonist and liver toxin.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.499008185105124 0.262844261554502 no 2513 0.308886808899468 759 2374 Ca(2+)-ATPase inhibitor.
SGTC_1373 2887-0003 58.5 µM -0.499140386786748 0.262792406237987 no 2514 0.308840243743174 735 776948
SGTC_3236 9132701 49.47 µM -0.501791077422553 0.261753794084165 no 2515 0.307907245073331 770 24282524
SGTC_2024 5144227 134 µM -0.502675931218214 0.261407553904105 no 2516 0.307596067219905 746 3475211
SGTC_1415 3966-0071 78.1 µM -0.502746283700021 0.261380035322434 no 2517 0.307571332193831 759 2893185
SGTC_1755 st041960 45.185 µM -0.504054506005415 0.260868591498597 no 2518 0.307111537574248 793 2257073
SGTC_2442 5158906 48.48 µM -0.505938209573589 0.260133071043274 no 2519 0.30645001388324 764 1893835
SGTC_1947 st076332 61.6 µM -0.506754281004726 0.259814755855953 no 2520 0.306163619427802 769 24208416
SGTC_54 0159-0055 9 µM -0.508786294869302 0.259023026738756 no 2521 0.305451013452573 801 3319099
SGTC_297 0986-0032 24 µM -0.510395952376227 0.258396746228358 no 2522 0.304887046002631 776 2847425
SGTC_2592 piperlongumine 83.33 µM -0.511478740584799 0.257975900183885 no 2523 0.304507935543085 772 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2718 lomofungin 53.02 µM -0.511528549483733 0.257956549574143 no 2524 0.304490501284777 772 5351222 A RNA synthesis inhibitor.
SGTC_2095 5432005 200 µM -0.514111744923768 0.256954018917178 no 2525 0.303586933199548 803 783734
SGTC_764 1951-2361 146 µM -0.515596554074669 0.256378687607564 no 2526 0.303068108776837 756 5438930
SGTC_678 1218-2179 85.9 µM -0.515952777750991 0.256240758583253 no 2527 0.302943695544024 774 6820081 YOR116C RPO31
SGTC_1993 st073995 70.8 µM -0.516135328233431 0.256170090432909 no 2528 0.302879947564847 763 3098394
SGTC_2001 4023502 57.655 µM -0.516172125474429 0.256155846875528 no 2529 0.302867098423327 755 108941 YCR052W RSC6
SGTC_97 0535-0701 19.132 µM -0.516744521967507 0.255934335564536 no 2530 0.30266725607893 741 2832013 YGL099W LSG1
SGTC_233 rapamycin 362 pM -0.519408075139234 0.25490488522936 no 2531 0.301738100667068 779 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2614 arthonioic acid 13.39 µM -0.519679589327053 0.254800068160172 no 2532 0.301643457568197 769 6710684
SGTC_1055 3448-0672 86 µM -0.520008472083557 0.254673134387101 no 2533 0.301528835095782 765 748378
SGTC_1964 st076914 61 µM -0.520762974868477 0.254382055834154 no 2534 0.301265949282418 793 24208661
SGTC_2772 vinpocetine 57.06 µM -0.520768193706974 0.254380043073289 no 2535 0.301264131280708 788 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2171 5739187 198.077 µM -0.521061399911594 0.254266975003928 no 2536 0.301161999751672 741 2262761
SGTC_2418 pentamidine 31.67 µM -0.521764949270949 0.253995775263525 no 2537 0.300916998421671 773 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3031 9088762 49.47 µM -0.522301696455186 0.253788975476618 no 2538 0.30073014410579 770 205253
SGTC_49 0717-0965 32.132 µM -0.523014186502987 0.253514601490236 no 2539 0.300482190480577 802 5889349 YGL099W LSG1
SGTC_16 erodoxin 22.806 µM -0.524013117484228 0.253130184078432 no 2540 0.30013470813726 781 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_6 0844-0013 19.835 µM -0.525183313621211 0.252680249165249 no 2541 0.299727881788143 793 1584900
SGTC_853 0419-0306 21 µM -0.525213278644943 0.252668733287862 no 2542 0.299717467531822 771 762713
SGTC_1357 1503-1303 39.5 µM -0.525300442858479 0.252635236724891 no 2543 0.299687174796267 764 292895
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.529198095943684 0.251139791404092 no 2544 0.298334018700426 783 688788
SGTC_1621 st003705 32.4 µM -0.529888349641046 0.250875444843037 no 2545 0.298094672115539 755 24207032
SGTC_1865 st057639 52.2 µM -0.53056164369863 0.250617735290007 no 2546 0.297861290639873 764 688818
SGTC_2285 7945142 200 µM -0.530793707282684 0.250528943305569 no 2547 0.297780870594082 800 2970608
SGTC_3255 9139072 49.47 µM -0.531623577560928 0.250211555427614 no 2548 0.297493365800735 761 17646060
SGTC_1856 st057054 55.7 µM -0.532027061671647 0.250057318066056 no 2549 0.297353626369223 801 1266018
SGTC_1307 1187-1599 12.2 µM -0.532082111281264 0.250036278505412 no 2550 0.297334563256496 774 1538471
SGTC_3028 9087778 49.47 µM -0.532273645376009 0.249963082886321 no 2551 0.297268241323837 746 17217395
SGTC_1632 st005650 90 µM -0.532828455613188 0.249751123840701 no 2552 0.297076167021749 756 2759605
SGTC_2987 9018338 71.43 µM -0.533126556861051 0.249637277021508 no 2553 0.296972988352352 773 5055682
SGTC_2234 tolnaftate 200 µM -0.53335373910141 0.249550533148105 no 2554 0.296894367146791 782 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3341 9147222 25.867 µM -0.53400977792757 0.249300131001484 no 2555 0.296667384556974 789 1939759
SGTC_2170 morpholine 200 µM -0.535438715680343 0.248755185304816 no 2556 0.296173262278925 769 121171 Reacts with secondary amines.
SGTC_1076 itraconazole 331 nM -0.535778436347298 0.248625721392159 no 2557 0.296055843494035 748 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2304 7443016 91.4 µM -0.536768314874671 0.24824869401218 no 2558 0.295713830371267 787 939854
SGTC_1539 benzyladenosine 56 µM -0.536807343836553 0.248233834814302 no 2559 0.295700349188247 754 92208 A nucleotide analog.
SGTC_1713 st033146 12.748 µM -0.538011929560052 0.247775455415372 no 2560 0.295284406345377 798 674619
SGTC_2369 9071472 200 µM -0.53973760480902 0.247119574769801 no 2561 0.294689001210413 761 17296037
SGTC_1030 k029-0042 36.7 µM -0.540018099156705 0.247013054561655 no 2562 0.294592275331153 767 6080581
SGTC_1699 st031318 29.054 µM -0.540220137873069 0.246936343796094 no 2563 0.294522613226431 767 5340658
SGTC_1300 1094-0077 113 µM -0.540550223203151 0.246811043278931 no 2564 0.294408817543095 763 5532636
SGTC_1238 0333-0287 48.8 µM -0.541489105105262 0.246454829520866 no 2565 0.294085252548709 759 7226
SGTC_2049 5262831 67.185 µM -0.541500611389193 0.246450465722121 no 2566 0.294081288180736 781 763417
SGTC_3098 9119039 49.47 µM -0.541750737926773 0.246355614584693 no 2567 0.293995115842902 784 17161528
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.541863348293196 0.246312917702163 no 2568 0.293956323696802 798 688751
SGTC_272 doxorubicin 8.13 µM -0.544226460479635 0.245417845588461 no 2569 0.293142822684547 759 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_668 1682-0499 62.6 µM -0.545686063154946 0.244865868723826 no 2570 0.292640876818052 796 682214
SGTC_2811 7967822 32.47 µM -0.546494732004888 0.244560342896484 no 2571 0.292362953959716 758 2232244
SGTC_2282 7944268 200 µM -0.546665694860381 0.244495777164015 no 2572 0.292304213261358 805 2970414
SGTC_2773 thioridazine 9.09 µM -0.546821888072344 0.24443679735483 no 2573 0.292250552026442 786 5452 An antipsychotic.
SGTC_3239 9133757 49.47 µM -0.548040765082126 0.243976803070511 no 2574 0.291831956080643 804 17036923
SGTC_1218 1348-1416 30.7 µM -0.548185635951563 0.243922161049657 no 2575 0.291782222010415 773 6787668
SGTC_362 0310-0100 9.03 µM -0.548432162564024 0.243829191958832 no 2576 0.291697598672582 760 790235
SGTC_1080 nisoldipine 24.4 µM -0.54858358304813 0.243772098377566 no 2577 0.291645627372088 789 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1468 k284-1086 134 µM -0.548883888234764 0.243658888690573 no 2578 0.291542567886222 774 15996457
SGTC_2432 5630864 12.22 µM -0.548974179138436 0.243624856185604 no 2579 0.291511584948857 791 5714970
SGTC_3355 9151058 44.0485 µM -0.549344596359261 0.243485265160453 no 2580 0.29138449393931 773 17015728
SGTC_2136 5328288 199.296 µM -0.549488774717933 0.243430943504239 no 2581 0.291335032999959 767 262395
SGTC_562 3772-2733 112 µM -0.550158442265059 0.243178720689863 no 2582 0.29110535235487 778 2876874 YIL048W NEO1
SGTC_2733 amorolfine 100 µM -0.550543524485561 0.243033747773901 no 2583 0.290973316273194 793 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1019 4262-0212 3.4 µM -0.550864452320669 0.242912962949599 no 2584 0.290863298678199 788 4677213
SGTC_2636 apigenin dimethyl ether 100 µM -0.551753380015451 0.242578574582622 no 2585 0.29055866604103 797 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1818 st052136 56.3 µM -0.554908621222666 0.241393681233179 no 2586 0.28947858235381 776 674169
SGTC_342 k048-0088 23.3 µM -0.557253498370492 0.240515146025233 no 2587 0.288677121181956 762 6820570
SGTC_920 mycophenolic acid 780.421 nM -0.557993187203521 0.240238374759322 no 2588 0.288424518164172 768 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.559077248635825 0.239833062480292 no 2589 0.288054500594342 769 5377381
SGTC_2727 riluzole 51.77 µM -0.559660960306565 0.239614977138052 no 2590 0.287855357883831 785 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2059 5238311 157 µM -0.560259260928563 0.239391553480727 no 2591 0.287651305420531 776 703021
SGTC_2203 7227154 166.4 µM -0.561247414650116 0.239022796089124 no 2592 0.287314442002573 764 896304
SGTC_2056 5235370 200 µM -0.562584623891978 0.238524273650482 no 2593 0.286858882347009 774 5511916
SGTC_1363 1636-0063 10.4 µM -0.563509690986789 0.238179734491468 no 2594 0.286543931476033 778 6072185
SGTC_2939 9044578 71.43 µM -0.56383462710587 0.238058777508946 no 2595 0.2864333417802 778 2653634
SGTC_641 4092-0595 30 µM -0.563909625935729 0.23803086409007 no 2596 0.28640781933955 779 786260
SGTC_92 0063-0024 660.874 µM -0.563979464280439 0.238004872938118 no 2597 0.286384054005847 786 3594437
SGTC_2931 9014674 55.67 µM -0.563990934736691 0.23800060422321 no 2598 0.286380150806656 778 2996810
SGTC_1128 3448-9350 235 µM -0.56540945564564 0.237473027220127 no 2599 0.285897647270878 743 619386
SGTC_398 bronopol 33.3 µM -0.566566538174718 0.237043160348136 no 2600 0.285504357261358 775 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.567895941821209 0.236549802938131 no 2601 0.285052813852629 788 1241132 A phosphatase inhibitor.
SGTC_2796 7949634 45.45 µM -0.568004117422276 0.236509682567865 no 2602 0.285016086062566 781 2971588
SGTC_2781 5567276 71.43 µM -0.568017985860369 0.23650453928631 no 2603 0.285011377612378 798 2853274
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.568024723604324 0.236502040532964 no 2604 0.2850090901056 806 165506
SGTC_2405 ticlatone 3.52 µM -0.568436401071183 0.236349393784244 no 2605 0.284869339608183 764 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1142 3253-1408 9.78 µM -0.568998079351946 0.236141215438489 no 2606 0.28467872168163 796 256655
SGTC_929 2805-0021 398 µM -0.569301057470993 0.236028962708247 no 2607 0.28457592465414 818 3098024
SGTC_2092 5303694 80.6725 µM -0.569670248451278 0.235892218010217 no 2608 0.284450686321833 790 1963699
SGTC_2343 7990716 14.84 µM -0.569870579718321 0.235818035565441 no 2609 0.284382740229237 808 6456862
SGTC_2652 actinonin 100 µM -0.570499206265482 0.235585339378069 no 2610 0.284169580155095 785 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_965 1291-5240 308 µM -0.572609345607784 0.234805164501685 no 2611 0.28345461524836 809 2834598
SGTC_2270 7924575 90.91 µM -0.572946878621169 0.234680502161206 no 2612 0.283340331154052 788 1262135
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.574616266667474 0.234064479213981 no 2613 0.282775424139679 773 6857784
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.574823393051354 0.23398810975169 no 2614 0.282705372044558 771 15053
SGTC_144 4161-2749 112.381 µM -0.574902853300791 0.233958815667812 no 2615 0.282678500052656 786 797501 YMR168C CEP3
SGTC_2451 5856223 45.7 µM -0.576142728910175 0.233501982224364 no 2616 0.282259356059079 792 2179896
SGTC_1917 st066507 28.5 µM -0.576198536033416 0.233481431674671 no 2617 0.282240497314953 764 3156428
SGTC_202 3594-0513 34.79 µM -0.576678739730235 0.23330464176872 no 2618 0.282078248493625 792 708429
SGTC_1478 0453-0656 35.7 µM -0.576974119265081 0.233195932910583 no 2619 0.281978469448986 811 5258496
SGTC_2315 7733312 200 µM -0.577261031166534 0.233090367329684 no 2620 0.281881567045559 773 726316
SGTC_3187 9109394 49.47 µM -0.577328728968103 0.23306546265514 no 2621 0.281858704946336 773 17098090
SGTC_684 1140-0066 328 µM -0.577645352482841 0.232949002780077 no 2622 0.281751790468715 802 6813534
SGTC_756 0508-1999 28.3 µM -0.578098675827652 0.232782318509007 no 2623 0.28159875050546 787 6753853
SGTC_3274 9138298 49.47 µM -0.579129212767459 0.23240364296165 no 2624 0.281250995009414 793 17015756
SGTC_1526 st051518 75 µM -0.57974346182332 0.23217809739233 no 2625 0.281043814861161 776 673993
SGTC_2293 7624732 200 µM -0.581207863378046 0.231640876803371 no 2626 0.280550184316026 794 894453
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.581372526236016 0.231580513042772 no 2627 0.280494704880597 772 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3008 9078912 71.4286 µM -0.581900877813176 0.231386883841861 no 2628 0.280316724600092 791 16648731
SGTC_2314 7727897 200 µM -0.582119665147197 0.231306729550729 no 2629 0.280243040011456 770 900724
SGTC_2769 toremifene 3.73 µM -0.58314227206689 0.230932295691397 no 2630 0.279898764423435 779 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2735 sertaconazole 140 nM -0.583407570450602 0.230835210359349 no 2631 0.279809481359456 807 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2423 st077119 87.2 µM -0.583580347755237 0.230771995160884 no 2632 0.279751342610644 774 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.583949331046626 0.230637025134385 no 2633 0.279627201099797 792 5379071
SGTC_2940 9060638 45.86 µM -0.584002812086825 0.230617466018916 no 2634 0.279609210045642 775 4027022
SGTC_3351 9150312 21.596 µM -0.584389715330673 0.230475995160817 no 2635 0.279479072300008 790 4904905
SGTC_706 4262-0057 46.9 µM -0.584935618322316 0.230276468707806 no 2636 0.279295503866869 793 883298
SGTC_460 trequinsin 123 µM -0.58508517955244 0.230221821240048 no 2637 0.279245221786539 808 5537 A vasodilator.
SGTC_922 1866-0035 480 µM -0.585372774166691 0.230116758797059 no 2638 0.279148545621743 792 3156169
SGTC_1027 k015-0025 8.67 µM -0.587469119819069 0.229351744544019 no 2639 0.278444342017126 780 3598955
SGTC_1078 idebenone 36.1 µM -0.5887939536275 0.228869012333385 no 2640 0.277999751189956 806 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3220 9131269 49.47 µM -0.589047984687713 0.228776515751801 no 2641 0.277914542446191 803 17722206
SGTC_574 1315-0397 40 µM -0.589658179566258 0.228554420263406 no 2642 0.277709919027436 808 6794277
SGTC_2301 7769476 200 µM -0.590217274259044 0.228351030312079 no 2643 0.277522496222608 796 977820
SGTC_1557 sumaresinolic acid 42.3 µM -0.590230214791016 0.228346323952573 no 2644 0.277518158958188 775 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_709 3807-1509 243 µM -0.590255001263861 0.228337309479082 no 2645 0.277509851394786 825 1886677 YPL242C IQG1
SGTC_2947 9072639 7.68 µM -0.591905425058008 0.227737524965499 no 2646 0.276956960401859 797 16488146
SGTC_1979 st071809 45.3 µM -0.592506210382795 0.227519412465301 no 2647 0.276755831648735 823 4976333
SGTC_2924 9010168 62.78 µM -0.593248327085284 0.227250152705511 no 2648 0.276507487312478 788 2993929
SGTC_998 3996-0085 177 µM -0.593422837671124 0.227186861693431 no 2649 0.276449104396468 801 715391
SGTC_804 1595-0054 20.9 µM -0.594120274990841 0.226934016295318 no 2650 0.276215835519051 796 761523 Stimulates phospholipase C.
SGTC_950 1165-0508 94.1 µM -0.596096022485521 0.226218601101071 no 2651 0.275555540593932 783 6148369
SGTC_1388 3346-4487 254 µM -0.596434898712451 0.226096022682582 no 2652 0.27544236617689 814 3345614
SGTC_1387 3342-1166 1.8 µM -0.597817455151608 0.225596313103088 no 2653 0.274980871215259 781 3418228
SGTC_2253 7938677 135.83 µM -0.597829558165891 0.225591941365106 no 2654 0.274976832932548 781 2301972
SGTC_2805 7950783 58.44 µM -0.598112639707238 0.225489702964969 no 2655 0.274882388491595 790 1178958 YDL195W SEC31
SGTC_1896 st058441 89 µM -0.598213303660676 0.225453353255424 no 2656 0.27484880784953 771 688759
SGTC_2596 sinensetin 100 µM -0.598260747578956 0.225436222427466 no 2657 0.274832981661424 784 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_964 1287-0107 19.4 µM -0.598286087732381 0.225427073025372 no 2658 0.27482452895941 783 51516812 YPR165W RHO1
SGTC_917 harmaline 728.087 nM -0.598768636853832 0.22525288231877 no 2659 0.274663589755119 769 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1277 0873-0036 22 µM -0.599279257633732 0.225068641340321 no 2660 0.274493338755558 797 5965735
SGTC_424 splitomicin 100 mM -0.600363908858463 0.224677563530522 no 2661 0.274131867605582 804 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_974 1326-0144 138 µM -0.602046634287786 0.224071609777279 no 2662 0.273571547891144 801 5411856
SGTC_109 0132-0036 33.701 µM -0.602523215511864 0.22390016049415 no 2663 0.273412957287199 762 67274 A color developer.
SGTC_59 0330-0160 1.33 µM -0.602924533616773 0.223755844827381 no 2664 0.27327944709514 823 4293482
SGTC_1905 st060207 84.5 µM -0.603536446497646 0.223535900216196 no 2665 0.273075938576292 782 1948547
SGTC_1161 k007-0610 110 µM -0.605142006269567 0.222959386369876 no 2666 0.272542322730244 813 5843850
SGTC_2116 5511452 16.8835 µM -0.605724072353404 0.222750591264974 no 2667 0.272348998087467 811 870744
SGTC_1042 0350-0096 82 µM -0.605989589460825 0.222655383650328 no 2668 0.272260833137754 789 3122515
SGTC_1785 bathophenanthroline 24 µM -0.60632440314578 0.222535361136747 no 2669 0.272149678482234 787 72812 An iron chelator.
SGTC_1362 1611-0397 101 µM -0.607260537262779 0.222199975802228 no 2670 0.271839011467507 809 27816
SGTC_3312 9133330 71.43 µM -0.607563088023419 0.222091643760018 no 2671 0.271738644215735 824 17617324
SGTC_898 1000-0849 28.3 µM -0.607676389759613 0.222051082432394 no 2672 0.271701062596351 814 6751807
SGTC_423 5-fluorouracil 457 µM -0.608600365391311 0.221720462719957 no 2673 0.271394681113981 809 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_55 0767-0285 6.563 µM -0.608680783907773 0.221691700437706 no 2674 0.271368023248529 817 3116166
SGTC_3050 9093513 49.47 µM -0.611335945375305 0.220743260052081 no 2675 0.270488599441647 814 25236664
SGTC_860 0443-0016 25.1 µM -0.611805385017484 0.220575815337547 no 2676 0.270333263233215 804 5337942
SGTC_2198 6589944 200 µM -0.611846764754756 0.22056105906448 no 2677 0.270319572937814 781 5290268
SGTC_999 SEC7.066 22.7 µM -0.611984671271326 0.220511884822154 no 2678 0.270273949704796 802 740511 YDR170C SEC7
SGTC_1072 oxiconazole 14.9 nM -0.613274420041909 0.220052294767428 no 2679 0.269847452134404 784 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_707 0865-0008 204 µM -0.613542598686886 0.219956800841192 no 2680 0.269758812436983 816 723043
SGTC_982 1491-0518 27.5 µM -0.613737092355329 0.21988755978034 no 2681 0.269694536576195 808 3091256
SGTC_1094 duloxetine 25.4 µM -0.614659489259219 0.219559350635203 no 2682 0.269389809273584 788 60834 A selective serotonin reuptake inhibitor.
SGTC_1518 st038567 90.8 µM -0.614766102347032 0.219521433498151 no 2683 0.269354599213661 824 77966
SGTC_2836 9010338 19.48 µM -0.615124650008713 0.219393942974626 no 2684 0.269236202122491 778 2994051
SGTC_140 0062-0056 502.533 µM -0.615202615471743 0.219366226050876 no 2685 0.269210460370466 794 3758964
SGTC_262 fenpropimorph 62.5 µM -0.615411953009891 0.219291815969685 no 2686 0.269141349785459 823 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2440 5628896 157.78 µM -0.618212938338777 0.218297588190107 no 2687 0.268217491208089 822 5522048
SGTC_1604 st002052 72.4 µM -0.619245886364796 0.217931593106746 no 2688 0.267877193600656 777 6254834 YHR062C RPP1
SGTC_738 1315-0003 72.4 µM -0.620404900857186 0.217521351593936 no 2689 0.267495623333406 827 6251474
SGTC_76 0433-0009 400.328 µM -0.620740899081627 0.217402506000812 no 2690 0.267385057405314 833 2841569
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.622748432470183 0.216693205004101 no 2691 0.266724925133576 790 115019
SGTC_130 0136-0219 337.655 µM -0.623213997541409 0.216528903107142 no 2692 0.26657195227069 850 234244
SGTC_211 3455-0679 143.504 µM -0.624159487423627 0.216195453557702 no 2693 0.26626142489787 781 748649
SGTC_3338 9144300 39.5675 µM -0.624296051106038 0.216147315706428 no 2694 0.266216588406113 793 4901274
SGTC_1177 0983-0204 23.6 µM -0.624829282546398 0.215959414375955 no 2695 0.266041554842229 803 766818
SGTC_1057 3448-5381 134 µM -0.625042652655312 0.21588425304186 no 2696 0.265971532298589 791 5497911
SGTC_1469 k284-2957 126 µM -0.625120457014212 0.215856849603669 no 2697 0.2659460012463 798 23884841
SGTC_1479 0549-0158 134 µM -0.625169438371088 0.215839598936077 no 2698 0.265929928933051 788 5440202
SGTC_844 0330-0132 15.3 µM -0.625440512488828 0.215744144213075 no 2699 0.265840989946571 803 2828079
SGTC_166 k072-0058 166.424 µM -0.627845397831703 0.214898371767535 no 2700 0.265052611583547 811 5846229
SGTC_420 mitomycin C 81.9 mM -0.628262072713033 0.214752027665176 no 2701 0.264916136512009 801 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2756 carbadox 75.1 µM -0.628329122893723 0.214728483783054 no 2702 0.264894178653543 816 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_481 bay k-8644 50 µM -0.629019135953813 0.21448628096864 no 2703 0.264668264200925 826 2303 A calcium channel antagonist.
SGTC_2159 5658611 73.75 µM -0.632806869755564 0.213159573328251 no 2704 0.263429885038955 808 793844
SGTC_752 1896-0090 130 µM -0.632917744976548 0.213120809946738 no 2705 0.263393679592931 810 772567
SGTC_1756 st041558 35.5 µM -0.633719747502393 0.212840542171084 no 2706 0.263131867540064 836 3955792
SGTC_1385 3091-4834 14.1 µM -0.634130491433921 0.212697086953855 no 2707 0.262997832545847 794 4072814
SGTC_1090 efavirenz 20.7 µM -0.634213950665854 0.212667945130623 no 2708 0.262970602185612 801 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2261 9010538 184.68 µM -0.63444039421322 0.212588888597307 no 2709 0.262896727393659 843 6457250
SGTC_3141 9094609 49.47 µM -0.634874369529167 0.212437426034895 no 2710 0.262755177236375 819 25236309 YDL196W YDL196W
SGTC_2345 9052315 157.45 µM -0.635674213937821 0.212158436037141 no 2711 0.262494393372212 802 6469265
SGTC_2529 gangaleoidin 93.61 µM -0.636334115700349 0.211928420131936 no 2712 0.262279336656694 824 4565183
SGTC_2180 6301957 200 µM -0.636934925456819 0.211719128305131 no 2713 0.262083616074528 818 845462
SGTC_2005 4024620 188 µM -0.637521053178178 0.211515067570604 no 2714 0.26189275049208 822 236743
SGTC_696 1560-0013 611 µM -0.638114546604479 0.211308559847888 no 2715 0.261699559011778 804 1650269
SGTC_276 colchicine 750 µM -0.638499247524671 0.211174765185098 no 2716 0.261574371861799 825 2833 A microtubule depolymerizer.
SGTC_1121 fusaric acid 630.51 nM -0.638617411193049 0.211133679155164 no 2717 0.261535925895603 783 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2961 9083290 32.55 µM -0.639879551081843 0.210695119873211 no 2718 0.261125454599963 820 17741490
SGTC_1409 3909-8004 61.9 µM -0.642214729378253 0.209885119473346 no 2719 0.260366885314225 797 2119279
SGTC_1174 0739-0097 51.1 µM -0.642222470403226 0.209882437400929 no 2720 0.260364372575695 805 728447
SGTC_440 fluspirilene 35.1 µM -0.643631112106723 0.209394713571583 no 2721 0.259907335197892 822 3396 An atypical antipsychotic.
SGTC_1093 fluphenazine 7.97 µM -0.644007818147818 0.209264397125788 no 2722 0.259785182136134 825 6602611 An atypical antipsychotic.
SGTC_2307 7538926 6.34 µM -0.644759547177415 0.20900448919082 no 2723 0.259541510342 825 96582
SGTC_569 4130-2812 160 µM -0.645445861230285 0.208767364387837 no 2724 0.259319145818762 826 743552
SGTC_2458 5808907 16.39 µM -0.645531718847504 0.208737711329667 no 2725 0.259291335033958 828 2731747
SGTC_2317 5986382 200 µM -0.646675239919761 0.208343004705244 no 2726 0.258921075566536 842 877883
SGTC_1522 st012842 45.6 µM -0.646884612942186 0.208270783598917 no 2727 0.258853312535145 816 3491067 YOR116C RPO31
SGTC_3067 9117431 49.47 µM -0.647354540303997 0.20810874069687 no 2728 0.258701255189809 833 17150885
SGTC_1668 st014914 51.6 µM -0.648654888066365 0.207660735733638 no 2729 0.258280734623114 816 2839556
SGTC_1419 3993-2473 62.6 µM -0.649432534605054 0.207393087963739 no 2730 0.258029420238657 830 704026
SGTC_2266 7929956 200 µM -0.651638511211555 0.206634952996704 no 2731 0.257317198914369 818 2967153
SGTC_1255 0566-0045 221 µM -0.652617856062783 0.206298905192941 no 2732 0.257001335562638 809 2788469
SGTC_2801 7907800 81.82 µM -0.655197395138906 0.205415325803924 no 2733 0.256170335619876 829 6620925
SGTC_256 clotrimazole 625 nM -0.655218229480146 0.205408198499032 no 2734 0.256163629533861 796 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1431 4049-0260 9.09 µM -0.656635487020128 0.204923707962325 no 2735 0.255707662564735 830 3854841
SGTC_375 3970-0961 9.27 µM -0.657946985768854 0.204475976985209 no 2736 0.255286098656632 808 2898222
SGTC_1771 st048882 4.1505 µM -0.65859302388212 0.204255641012789 no 2737 0.255078571904308 801 4580403
SGTC_902 1120-0002 2.07 µM -0.659449067221894 0.203963899124823 no 2738 0.254803721192057 812 3280475
SGTC_1881 5652484 16 µM -0.659625830175238 0.20390368877474 no 2739 0.254746987047216 832 2255129
SGTC_2313 7726885 200 µM -0.659638531308655 0.203899362825399 no 2740 0.25474291072406 819 726423
SGTC_2364 9055074 200 µM -0.660663462126959 0.203550456282528 no 2741 0.254414080307127 824 6470630
SGTC_1018 4259-0013 28.1 µM -0.661879934318111 0.203136807759676 no 2742 0.254024086209427 822 6801262
SGTC_2787 5284540 71.43 µM -0.662607268302431 0.202889725419462 no 2743 0.253791056970782 824 736958
SGTC_2537 larixol 68.93 µM -0.662726737367016 0.2028491578026 no 2744 0.253752791224149 822 6708759
SGTC_3332 9141069 11.198 µM -0.663022519534607 0.202748741124926 no 2745 0.253658065714108 824 17332883
SGTC_2506 ethyl hematommate 54.16 µM -0.663452865290191 0.202602693787992 no 2746 0.253520278810836 815 3940691 An allergen.
SGTC_1614 st002383 48.6 µM -0.663918396917273 0.202444776172621 no 2747 0.2533712704839 798 1947235
SGTC_1505 k297-0037 20.6 µM -0.666739000930494 0.201489545903836 no 2748 0.252469431067767 815 4089396
SGTC_536 3852-0578 10.6 µM -0.669535885936967 0.200545020257283 no 2749 0.251576848480712 831 2869208
SGTC_1006 4099-6547 255 µM -0.669654097751922 0.200505158035275 no 2750 0.251539159762529 839 3146833
SGTC_1104 tacrolimus 29.8 µM -0.670113110559215 0.200350419381593 no 2751 0.251392843925481 822 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2323 6148992 148.28 µM -0.670732781952286 0.200141634656397 no 2752 0.251195387620174 827 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1503 4585-0012 61.3 µM -0.672530928653915 0.199536529183311 no 2753 0.25062287858253 824 2922052
SGTC_476 mead acid 10 µM -0.673155113029535 0.199326738754587 no 2754 0.250424307250471 835 5312531 An omega 9 fatty acid.
SGTC_744 1594-0068 283 µM -0.673374390779796 0.199253070315685 no 2755 0.250354568373021 833 668392
SGTC_399 oxolinic acid 75 µM -0.676456375365252 0.198219384169682 no 2756 0.249375467299752 813 4628 A DNA gyrase inhibitor.
SGTC_1902 st060212 70.5 µM -0.677667311979705 0.197814127952005 no 2757 0.248991328300496 813 688944
SGTC_2141 5621638 7.665 µM -0.677925586230933 0.197727757817034 no 2758 0.24890943808935 819 2856238
SGTC_1534 6-azauridine 81.6 µM -0.678119827707878 0.197662816058448 no 2759 0.248847859995873 826 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_363 0455-0021 3.06 µM -0.678682553262377 0.197474749895124 no 2760 0.248669511511891 826 4597466
SGTC_73 0327-0325 16.231 µM -0.678707708021466 0.197466345554961 no 2761 0.248661540630834 789 53298
SGTC_2877 9040724 71.43 µM -0.678735392713904 0.197457096200475 no 2762 0.24865276823779 824 6463895
SGTC_776 4476-4378 112 µM -0.678928679056076 0.197392527240046 no 2763 0.248591526574716 860 2892008
SGTC_302 1094-0063 18.9 µM -0.682102554437983 0.196334094217896 no 2764 0.247587052748604 829 5440289
SGTC_2357 9067248 200 µM -0.682340461379134 0.196254895179627 no 2765 0.247511846977889 842 9150235
SGTC_35 0133-0054 64.071 µM -0.683304865830208 0.195934044134684 no 2766 0.247207110068308 830 99677
SGTC_2951 9072950 58.06 µM -0.685377260331508 0.195245649654953 no 2767 0.246552944810067 839 16488155
SGTC_984 1492-0255 2.91 µM -0.685744729830326 0.195123739616591 no 2768 0.246437047464926 825 1585198
SGTC_695 3505-6186 243 µM -0.687547250005098 0.194526413951511 no 2769 0.245868968120834 837 1819379
SGTC_1429 4049-0205 9.46 µM -0.68809624289876 0.194344708024748 no 2770 0.245696088143687 815 22774478
SGTC_2157 5649910 96.377 µM -0.688296640814866 0.194278405982623 no 2771 0.245632998333794 837 2858091
SGTC_1892 st058411 7.36 µM -0.688361588115193 0.194256920997156 no 2772 0.24561255331734 841 3934738
SGTC_717 1532-0246 73.2 µM -0.68922019842939 0.193973023195903 no 2773 0.245342353926282 831 9561992
SGTC_1123 mangostin 811.285 nM -0.689639575872303 0.193834448825011 no 2774 0.245210436520742 780 5281650 An antioxidant.
SGTC_1991 st073000 8.92 µM -0.689718620211966 0.193808337061625 no 2775 0.245185576975477 842 4301969 YIL048W NEO1
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.690471827613254 0.193559627665818 no 2776 0.244948760288643 824 97141
SGTC_2081 5214970 32.255 µM -0.69061139983629 0.19351356224696 no 2777 0.24490489076743 831 2063512
SGTC_995 3931-2021 34.6 µM -0.693646163851823 0.192513601114201 no 2778 0.243952067833612 837 730143
SGTC_1992 st073643 23.3 µM -0.694423289168539 0.192258045586326 no 2779 0.243708396341808 837 3161292
SGTC_828 2074-0507 139 µM -0.695497690131609 0.191905073708619 no 2780 0.243371729129316 827 X828
SGTC_2427 5545055 42.75 µM -0.695736246279355 0.191826754944994 no 2781 0.243297010855974 829 5372858
SGTC_2287 7945887 168.79 µM -0.696035801999478 0.191728437540842 no 2782 0.243203204442308 827 1245853
SGTC_2091 4-phenylthiadiazole 200 µM -0.696343957319876 0.191627329860943 no 2783 0.243106725455307 835 270010
SGTC_3267 9137951 49.47 µM -0.698182950430047 0.191024624004338 no 2784 0.242531393774645 865 16643986
SGTC_966 1300-0360 30.2 µM -0.69943602518077 0.190614611954585 no 2785 0.242139790335184 836 70588
SGTC_2134 5324836 1.464 µM -0.700625373873077 0.190225951491134 no 2786 0.241768419519926 855 699272
SGTC_1484 3473-2379 286 µM -0.701987230765888 0.189781516459367 no 2787 0.241343563399038 844 671917
SGTC_600 1495-0418 41.6 µM -0.702630607316704 0.189571776087707 no 2788 0.241142991512752 848 5377768
SGTC_1390 3413-2614 145 µM -0.703813766410468 0.18918643938566 no 2789 0.24077437971431 855 3421432
SGTC_1949 st076024 69.1 µM -0.705085651241199 0.188772744407741 no 2790 0.240378467726071 843 2921930
SGTC_259 usnic acid 108.925 µM -0.705368180601418 0.188680924260823 no 2791 0.240290570219396 864 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1864 st057645 30.4 µM -0.707262147845233 0.188066108731638 no 2792 0.239701791858717 840 688666
SGTC_2040 5100729 123 µM -0.707279066011946 0.188060622371356 no 2793 0.239696536051462 836 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_74 000s-0487 160.283 µM -0.707531784277487 0.187978680603268 no 2794 0.239618033938511 808 677548
SGTC_2942 9052777 62.25 µM -0.708502464692876 0.187664150631093 no 2795 0.239316641075127 868 6469503
SGTC_407 eburnamonine 100 µM -0.708510744951878 0.187661468974691 no 2796 0.239314070974865 827 3195
SGTC_2206 7254556 146.969 µM -0.70854575317462 0.187650131423745 no 2797 0.239303204978689 824 4398905
SGTC_1928 4'-methoxychalcone 40.3 µM -0.708819290254246 0.187561559933382 no 2798 0.239218312695679 828 641818
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.709427382474587 0.18736475183011 no 2799 0.239029650129606 830 641818 YHR062C RPP1
SGTC_2472 5377652 49.4 µM -0.70978556052705 0.187248887824593 no 2800 0.238918562315351 856 1610903
SGTC_3019 9081971 49.47 µM -0.710437219397219 0.187038201833141 no 2801 0.238716524762629 846 16451803
SGTC_330 1488-0319 80.1 µM -0.711608824669207 0.186659782447494 no 2802 0.238353520461023 837 6846614
SGTC_364 0083-0097 67.7 µM -0.713167762867395 0.186156993110248 no 2803 0.237870975981201 846 5207356
SGTC_532 1548-0774 215 µM -0.71342732433946 0.186073360832864 no 2804 0.237790684917072 863 5932993
SGTC_391 gliotoxin 8.33 µM -0.715546050366608 0.185391565770352 no 2805 0.23713584813397 854 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_95 0471-0001 561.058 µM -0.717012203726392 0.184920674343688 no 2806 0.236683283306831 833 4015405
SGTC_2581 avocatin a 64 µM -0.718437586859153 0.184463590507408 no 2807 0.236243759081968 856 6710728 A skin care supplement.
SGTC_2416 tofa 880 nM -0.718741814074548 0.184366123719126 no 2808 0.236150007294836 832 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3166 9102297 49.47 µM -0.718758725202545 0.184360706757011 no 2809 0.236144796500237 840 25237072
SGTC_905 2-aminofluorene 215 µM -0.718902523474218 0.184314649384053 no 2810 0.236100490763798 844 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2720 fluspirilene 36.88 µM -0.719441543278509 0.184142069613526 no 2811 0.235934453944453 853 3396 An atypical antipsychotic.
SGTC_960 1222-0186 7.7 µM -0.720068628367824 0.183941420308059 no 2812 0.235741370971697 853 3126296
SGTC_3235 9132602 49.47 µM -0.720374927398995 0.183843462883783 no 2813 0.235647091487124 843 4912240
SGTC_1319 1306-0155 43.7 µM -0.720647522110474 0.183756311761536 no 2814 0.235563203755921 853 3122360
SGTC_2062 5245942 200 µM -0.72426489384419 0.182602241595346 no 2815 0.234451562600647 847 1376160
SGTC_2849 9019321 12.99 µM -0.726683765790787 0.181833066474542 no 2816 0.233709850307857 851 16489627
SGTC_1005 4092-0690 4.4 µM -0.726698621109516 0.181828348913971 no 2817 0.233705299160415 860 1529343
SGTC_2972 9093619 59.92 µM -0.727070964940353 0.181710129770337 no 2818 0.233591242149773 828 25236256
SGTC_1667 st014849 34.6 µM -0.729004209405794 0.181097098097405 no 2819 0.23299954379445 841 5348460
SGTC_2853 9015042 58.44 µM -0.72945623530545 0.180953947824409 no 2820 0.232861314676624 833 6457456
SGTC_149 3970-0822 46.1 µM -0.732379012966402 0.1800300574469 no 2821 0.231968632411676 842 3114250 YBL034C STU1
SGTC_2213 7173844 200 µM -0.732789259590401 0.179900615881633 no 2822 0.231843486518017 842 892728
SGTC_733 4069-0007 56.1 µM -0.733269831987646 0.179749059394571 no 2823 0.231696935561717 852 5717425 YNL287W SEC21
SGTC_2679 rapamycin 1 nM -0.735811257517283 0.178948912994941 no 2824 0.230922784618496 829 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_799 1310-0557 151 µM -0.736550570027061 0.17871656819715 no 2825 0.230697851973685 855 5354492
SGTC_1465 k213-0056 144 µM -0.736711325498795 0.178666072496439 no 2826 0.230648959019934 842 24048857 YMR208W ERG12
SGTC_2607 solasodine 47.35 µM -0.736802217945672 0.178637525794055 no 2827 0.230621317109875 866 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2337 9009472 200 µM -0.738324152587643 0.178159956664263 no 2828 0.230158746464542 840 5742383
SGTC_137 0438-0332 85.389 µM -0.738605527596385 0.178071751994553 no 2829 0.230073283370377 864 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1570 verbenone 133 µM -0.738993395303905 0.177950209425661 no 2830 0.229955503960949 850 29025 A natural terpanoid with antifungal properties.
SGTC_192 3455-0609 60.9 µM -0.740867510142183 0.177363672469911 no 2831 0.229386888378475 836 3769639
SGTC_1980 st071811 45.7 µM -0.741257526200882 0.177241763751046 no 2832 0.229268654752238 856 4974850
SGTC_2326 6164455 177.58 µM -0.741263617815384 0.177239860093059 no 2833 0.229266808346319 855 2888790
SGTC_667 1498-1044 59 µM -0.741826393038533 0.177064045910619 no 2834 0.229096263675161 874 6739982
SGTC_593 1203-0218 61.7 µM -0.742294955569138 0.176917748397486 no 2835 0.228954323736196 848 3666956
SGTC_3228 9131799 49.47 µM -0.742728204833915 0.176782544604298 no 2836 0.228823125035725 857 17015818
SGTC_2936 9038235 15.59 µM -0.743504855079756 0.176540339448258 no 2837 0.228588041603479 841 4749415
SGTC_2319 6033012 152.6 µM -0.745267634829805 0.175991380420334 no 2838 0.228054971355003 861 847246
SGTC_2243 6634756 200 µM -0.746207711536496 0.175699067232044 no 2839 0.227770975232007 819 885676
SGTC_1348 1493-0373 93.8 µM -0.746818926366376 0.175509177476502 no 2840 0.227586434742759 868 3010129
SGTC_1438 4092-1045 4 µM -0.747403271554771 0.175327757144281 no 2841 0.22741008559083 856 1351342
SGTC_43 0570-0105 72.5 µM -0.747472696030221 0.17530621098929 no 2842 0.227389139140967 845 1114046 YDL195W SEC31
SGTC_2401 5128683 200 µM -0.748266280378128 0.175060038306557 no 2843 0.227149779569989 868 708373
SGTC_1628 st004252 77.7 µM -0.750577216751958 0.174344427525453 no 2844 0.226453568435378 849 692968
SGTC_285 1486-1325 46 µM -0.754540714711772 0.17312141421258 no 2845 0.225262303583903 862 22310230
SGTC_1282 0886-0010 32.4 µM -0.756211719749093 0.172607435117809 no 2846 0.224761133593767 850 2836211 YNL267W PIK1
SGTC_682 0kpi-0099 17 µM -0.75778112946472 0.172125592373921 no 2847 0.224291010538627 865 1714895 YML126C ERG13
SGTC_721 1187-1332 279 µM -0.757815266893873 0.172115120993287 no 2848 0.224280790740584 873 25730
SGTC_421 streptovitacin 30 mM -0.760287019615748 0.171358011458374 no 2849 0.223541519551084 885 91467 include heat shock
SGTC_1187 1391-0724 117 µM -0.761319388848287 0.171042423129231 no 2850 0.223233161270422 862 6997986
SGTC_157 1348-1695 65.819 µM -0.761353012991289 0.171032150710295 no 2851 0.223223122150914 855 5380510
SGTC_2981 9013952 38.96 µM -0.76190640533201 0.170863142043768 no 2852 0.223057933397303 830 2996344
SGTC_931 2812-0076 566 µM -0.762053613423286 0.170818201989709 no 2853 0.223014003203405 862 3450959
SGTC_1273 0849-0096 14.1 µM -0.763831717338862 0.17027597555494 no 2854 0.222483766500563 861 5286025
SGTC_1887 st057648 70.8 µM -0.764334416568739 0.170122879378009 no 2855 0.222333990322343 860 688672
SGTC_2070 5230947 200 µM -0.764975683967352 0.169927710584424 no 2856 0.222143012116656 878 2835538
SGTC_180 1486-1293 102.781 µM -0.765987178507394 0.169620155601314 no 2857 0.221841965598833 858 4140536
SGTC_854 0422-0053 192 µM -0.767689875961703 0.169103240522222 no 2858 0.221335726156304 874 3596728
SGTC_3051 9093778 49.47 µM -0.768203241707152 0.168947588565726 no 2859 0.221183223952226 890 17217378
SGTC_1661 st013063 9.66 µM -0.770366219625761 0.168292787087776 no 2860 0.220541342838123 880 721395
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.771122875060262 0.168064109602873 no 2861 0.220317051492711 864 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2593 nobiletin 86.24 µM -0.771728841969585 0.167881117680184 no 2862 0.220137522284863 863 72344 An anti-infammatory.
SGTC_2112 5488546 200 µM -0.773036803252674 0.167486572540969 no 2863 0.219750300058249 878 600757
SGTC_1488 4013-0813 75.9 µM -0.774029483814037 0.167187530575521 no 2864 0.219456677945427 848 2910057
SGTC_585 0kpi-0023 191 µM -0.775147902615579 0.166851022975809 no 2865 0.219126134267868 834 64601
SGTC_2857 9024691 58.44 µM -0.776152596521427 0.16654910550221 no 2866 0.218829445699284 879 16478292
SGTC_1648 st011736 69.8 µM -0.779677269011824 0.165492707627577 no 2867 0.217790430893012 873 2855514
SGTC_171 k064-0041 9.68 µM -0.779685530972465 0.165490236495314 no 2868 0.217787998752232 855 53325
SGTC_2564 betulinic acid 100 µM -0.779934283595671 0.165415846370615 no 2869 0.217714778749751 878 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_148 3253-0744 288.01 µM -0.7805296031016 0.165237902365492 no 2870 0.217539604925132 865 6893655
SGTC_2393 9031399 185.94 µM -0.781015822326272 0.165092660929443 no 2871 0.217396594425687 876 1526623 YDL150W RPC53
SGTC_2446 5162541 200 µM -0.781410521426785 0.164974818808733 no 2872 0.217280542449879 865 1549321
SGTC_2883 9059145 45.46 µM -0.781865993331181 0.164838899951848 no 2873 0.217146666139777 883 16476510
SGTC_879 0831-1030 162 µM -0.782235305400491 0.16472874559494 no 2874 0.217038149680659 867 1549252
SGTC_3268 9137683 49.47 µM -0.784089888462323 0.164176302109384 no 2875 0.216493684076911 915 1953228
SGTC_2378 9074213 121.43 µM -0.784813347673291 0.163961124135945 no 2876 0.216281506520375 859 657714
SGTC_1447 4239-0816 81.9 µM -0.785419216812736 0.163781061751158 no 2877 0.216103908675842 856 1341554
SGTC_2719 novobiocin 32.65 µM -0.786797564763258 0.163371899447668 no 2878 0.21570018964846 887 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_320 4092-0846 5.34 µM -0.788388441194651 0.162900474309061 no 2879 0.215234764904914 848 1359356
SGTC_1470 k295-0292 231 µM -0.788388839773413 0.162900356308974 no 2880 0.215234648370309 876 5045612
SGTC_1227 3909-8010 46.6 µM -0.789687529101842 0.162516171693151 no 2881 0.214855138108053 860 15982272
SGTC_1940 st075990 51.1 µM -0.790918501202338 0.162152564231913 no 2882 0.214495775662423 895 1084979
SGTC_2428 5615643 7.78 µM -0.791053732079377 0.162112651733824 no 2883 0.2144563185048 864 2253075
SGTC_47 0149-0135 24.25 µM -0.792352394722974 0.161729685812815 no 2884 0.214077614523277 865 5239155
SGTC_3029 9088683 49.47 µM -0.793757785069508 0.161315911518715 no 2885 0.213668226418171 846 25236615
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.794521038274584 0.161091484488243 no 2886 0.213446083136615 866 688803
SGTC_975 1335-0046 28.5 µM -0.795137237433634 0.160910445954414 no 2887 0.213266837882424 873 16486740
SGTC_369 0957-0393 4.5 µM -0.796088818911859 0.160631133532447 no 2888 0.212990206264454 874 6997992
SGTC_2611 pyromycin 23.93 µM -0.796776927760432 0.160429354171437 no 2889 0.212790298549611 874 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_516 3992-2719 87.3 µM -0.797086827611979 0.160338534007257 no 2890 0.212700302980029 886 5350887 YDR037W KRS1
SGTC_543 3844-1095 191 µM -0.802298085733408 0.158816341516868 no 2891 0.211190274736608 880 4230703
SGTC_1150 3909-7983 10.9 µM -0.803762588164248 0.158390275481589 no 2892 0.210767049970392 871 23965914
SGTC_2786 7743617 45.45 µM -0.804016609167276 0.158316449820833 no 2893 0.21069369141211 866 583674
SGTC_2202 7226349 200 µM -0.806988498577804 0.15745441247238 no 2894 0.209836554768414 862 844334
SGTC_595 3909-8003 73.7 µM -0.809067355683121 0.156853248533477 no 2895 0.209238202060964 884 699517
SGTC_1734 st037168 69.4 µM -0.809857123875908 0.156625259739305 no 2896 0.209011148401564 891 708907
SGTC_170 4197-0004 226 µM -0.809943021638816 0.156600476095019 no 2897 0.20898646205825 884 218692
SGTC_955 1216-0110 33 µM -0.811312802663595 0.156205609006708 no 2898 0.208593029838189 878 3619719
SGTC_729 4092-0585 94.1 µM -0.812813199050541 0.155773842817775 no 2899 0.208162583405223 870 2169061
SGTC_1937 st074714 47.2 µM -0.814145746757077 0.155391038551554 no 2900 0.207780730689612 888 17250970
SGTC_638 3970-0837 4.09 µM -0.814247913484472 0.155361714506772 no 2901 0.207751471043859 859 4118451 YLR208W SEC13
SGTC_1651 st011928 86.1 µM -0.816410285141571 0.154741924020611 no 2902 0.207132758040765 892 720198
SGTC_2354 9060492 162 µM -0.819342350039015 0.153904132824903 no 2903 0.2062955582759 897 6471895
SGTC_2643 anethole 100 µM -0.821328847447779 0.153338231544205 no 2904 0.205729490148965 898 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1091 telmisartan 47.6 µM -0.823456610260428 0.152733618411287 no 2905 0.205124190943946 898 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_373 0844-0104 25.9 µM -0.823823398822947 0.15262955383519 no 2906 0.205019955148721 864 5375804
SGTC_3167 9103034 49.47 µM -0.824408068756739 0.152463769630336 no 2907 0.204853865854098 869 5127859
SGTC_1026 k007-1105 30.6 µM -0.825001095618895 0.152295737923288 no 2908 0.204685484337833 870 7066794
SGTC_3115 9123671 49.47 µM -0.828332411576337 0.151354109032403 no 2909 0.203741136050108 897 3286988
SGTC_325 2810-4341 181 µM -0.829121756437959 0.151131561643404 no 2910 0.203517756915929 859 774970
SGTC_1156 4092-0367 4.88 µM -0.831088265891787 0.150578072495842 no 2911 0.202961884026926 877 1357585
SGTC_108 0509-0257 621.132 µM -0.831237468457612 0.150536133463853 no 2912 0.202919746003789 884 536624
SGTC_343 4130-2827 29.8 µM -0.838743005362208 0.148436456992219 no 2913 0.200806769940372 871 1118244
SGTC_2897 9048598 12.99 µM -0.840280433373151 0.148008789603855 no 2914 0.200375584759995 887 6467404
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.840438484481092 0.147964871216686 no 2915 0.200331289489741 908 442882
SGTC_1633 st005664 67.9 µM -0.843523904715199 0.147109258644089 no 2916 0.199467751120735 905 2063822
SGTC_538 2922-0838 53.3 µM -0.844830090556084 0.146748043885183 no 2917 0.199102855755396 899 777039
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.845754675971983 0.146492717516432 no 2918 0.198844807323447 916 4620898
SGTC_3057 9095946 49.47 µM -0.84687437809914 0.14618390868189 no 2919 0.198532572581279 895 24540043
SGTC_2489 cantharidin 73.42 µM -0.847516178234792 0.14600710034807 no 2920 0.198353736706901 888 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2776 terbinafine 19.92 µM -0.848497211592049 0.145737115052191 no 2921 0.198080562355671 867 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2268 7933382 153.85 µM -0.850023512041371 0.145317737131852 no 2922 0.197656007195861 889 935025 YOR257W CDC31
SGTC_3147 9097027 49.47 µM -0.850337482396778 0.145231569032346 no 2923 0.197568741573435 913 25236841
SGTC_205 1486-1330 71.903 µM -0.85099733290005 0.145050587370472 no 2924 0.197385417176985 891 4118834
SGTC_469 w7 172 µM -0.851060603086374 0.145033241807619 no 2925 0.197367844407024 876 45115570 A P450 inhibitor.
SGTC_15 0266-0086 27.098 µM -0.851146772627605 0.145009620617394 no 2926 0.197343913052876 909 1712902 YIL048W NEO1
SGTC_789 1309-1135 70.6 µM -0.851484850975326 0.144916970041463 no 2927 0.197250037516257 871 3092424
SGTC_2666 tannic acid 100 µM -0.853401647305056 0.144392424508576 no 2928 0.196718304150468 875 16134267 A thiamine antagonist.
SGTC_2721 ifenprodil 61.44 µM -0.853734164275842 0.144301559176853 no 2929 0.196626149948767 891 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2760 etidronate 98.04 µM -0.855115766727772 0.143924428077439 no 2930 0.196243530941103 881 3305 A chelator and antioxidant.
SGTC_892 0929-0076 29 µM -0.858339571792799 0.143047025010909 no 2931 0.195352492259648 891 5751038
SGTC_2913 7966556 36.57 µM -0.858441258240809 0.143019408559912 no 2932 0.195324426832899 851 2976516
SGTC_360 0957-0399 1.01 µM -0.859029657224232 0.142859679321032 no 2933 0.19516207700624 913 6752301 YPR165W RHO1
SGTC_1092 toremifene 6.32 µM -0.859506625434453 0.142730288059455 no 2934 0.195030533132262 905 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2299 7976368 114.88 µM -0.860355289247924 0.142500259690254 no 2935 0.194796612012908 893 2979718
SGTC_1767 st044992 70.3 µM -0.863024174638551 0.14177849925645 no 2936 0.194062087770164 899 9600693
SGTC_2012 4023501 200 µM -0.863705382999296 0.141594673878698 no 2937 0.193874877895207 901 3477460
SGTC_21 0849-0113 22.993 µM -0.864570110750678 0.141361558124244 no 2938 0.193637391781011 868 1560156
SGTC_1065 prochlorperazine maleate 2.48 µM -0.865629707206176 0.141076263963221 no 2939 0.193346629525748 900 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_203 k066-0004 30.888 µM -0.867200212610704 0.140654127325151 no 2940 0.192916159902401 916 6795412
SGTC_472 calcifediol 10 µM -0.86723612894536 0.140644483399751 no 2941 0.19290632222167 898 5283731 A vitamin D metabolite.
SGTC_991 3996-0057 64.7 µM -0.870653991164801 0.139728803317416 no 2942 0.191971553500685 884 715343
SGTC_703 3875-0075 71.8 µM -0.871281025244727 0.139561255493492 no 2943 0.191800364167472 923 2850814
SGTC_1075 aripiprazole 15.2 µM -0.872235692546659 0.139306424280733 no 2944 0.191539905796427 898 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1056 3448-1962 115 µM -0.872663352149629 0.139192371006981 no 2945 0.191423299305647 901 715507
SGTC_210 3551-0445 56.827 µM -0.873260771005844 0.139033150765338 no 2946 0.19126047877555 892 2865180 YOR207C RET1
SGTC_1339 1486-1321 22.7 µM -0.873858060127708 0.138874089088598 no 2947 0.191097778497304 901 3469382
SGTC_1264 0783-0040 158 µM -0.874293305477743 0.138758258718563 no 2948 0.190979272068519 891 2855798
SGTC_2867 9039098 71.43 µM -0.874335582322204 0.138747011232376 no 2949 0.190967763542918 884 6463460
SGTC_914 3820-6779 408 µM -0.877817650214047 0.137822760542758 no 2950 0.190021342214632 894 2893481
SGTC_2929 9013348 24.6 µM -0.877978396767595 0.137780195010489 no 2951 0.189977721248045 901 2995952
SGTC_2553 4-methylesculetin 85.09 µM -0.878716088758158 0.137584969928472 no 2952 0.189777616513401 887 5319502
SGTC_2228 7354201 200 µM -0.879350958461301 0.137417107296488 no 2953 0.189605506948181 922 753451
SGTC_2047 4141938 200 µM -0.879711554735581 0.137321826185816 no 2954 0.189507794122303 899 3807862
SGTC_105 0111-0055 734.78 µM -0.880595400887051 0.137088476514685 no 2955 0.189268424379407 902 5179370
SGTC_1137 ixabepilone 100 µM -0.882353033181237 0.13662523861081 no 2956 0.188792962867965 887 154225 A novel microtubule stabilizer.
SGTC_524 r073-0010 27.8 µM -0.882851707056355 0.136494004314552 no 2957 0.188658199512492 900 2772106
SGTC_1749 st037932 54.2 µM -0.884209086939467 0.136137224148514 no 2958 0.188291676967865 926 594497
SGTC_349 k015-0014 24 µM -0.885167592724542 0.135885670765431 no 2959 0.188033124064763 904 2196908
SGTC_1646 st011709 75.6 µM -0.885580614998322 0.13577737403692 no 2960 0.187921780640584 899 5757843
SGTC_341 1486-1430 230 µM -0.890040845333879 0.134611642601651 no 2961 0.186721977187379 903 2054753 YPL210C SRP72
SGTC_1675 st018485 24.5 µM -0.893363904383197 0.133747601720462 no 2962 0.185831163012353 910 3323024
SGTC_2080 5212524 12.4 µM -0.896118666299563 0.133034222198398 no 2963 0.185094694325389 888 260183
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.899720502032452 0.132105439869773 no 2964 0.184134504986971 916 368090
SGTC_1243 0416-0003 5.65 µM -0.900213485103546 0.131978666194551 no 2965 0.184003325566897 901 2141977
SGTC_253 dyclonine 31.25 µM -0.900476302107343 0.131911115461042 no 2966 0.183933415546697 891 3180 An oral anasthetic.
SGTC_3350 9150499 3.57 µM -0.901685971493972 0.131600506821559 no 2967 0.183611853596949 916 4910996 YPR165W RHO1
SGTC_291 SEC14.278 35.5 µM -0.903117664946503 0.13123354144352 no 2968 0.183231724780733 897 1068044
SGTC_3161 9100388 49.47 µM -0.903174082997152 0.131219095104078 no 2969 0.183216755286894 907 25236368
SGTC_1173 0443-0020 122 µM -0.906112656960873 0.130468165410313 no 2970 0.182438113358813 915 5331295
SGTC_1466 k213-0079 57.5 µM -0.906424071481249 0.130388760377128 no 2971 0.182355718323855 925 3657981
SGTC_250 brefeldin a 552.239 µM -0.906911432292206 0.13026455934793 no 2972 0.182226817539804 894 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1545 lovastatin 49.4 µM -0.907075658672088 0.130222725667275 no 2973 0.18218339456554 894 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1936 st074407 74.3 µM -0.908291422989946 0.129913320965791 no 2974 0.181862136424711 915 809813
SGTC_125 0133-0007 11.75 µM -0.911444764316468 0.129113187789866 no 2975 0.181030538276033 889 26541
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.916655139213085 0.127798599592164 no 2976 0.179661690380544 920 5106787 A p450 inhibitor.
SGTC_2795 7780010 54.55 µM -0.917225194875459 0.127655339956728 no 2977 0.179512323459074 915 953673
SGTC_197 4544-0043 41.561 µM -0.9176650911842 0.127544866767628 no 2978 0.179397114477823 914 896523
SGTC_795 0685-0265 78 µM -0.918652712076471 0.127297083180928 no 2979 0.179138625646338 893 302754
SGTC_1459 k035-0031 35.7 µM -0.91930519705501 0.127133565438402 no 2980 0.178967980126395 885 3877128 YMR208W ERG12
SGTC_672 1441-0018 53.7 µM -0.919703160585136 0.127033904509918 no 2981 0.178863950277499 896 251141
SGTC_553 k007-0256 45.7 µM -0.920048456117384 0.126947477149923 no 2982 0.178773718976898 905 6287000
SGTC_625 k213-0058 121 µM -0.920730847336727 0.126776795237358 no 2983 0.178595483418518 912 3655420
SGTC_1473 k844-0725 134 µM -0.92105710982698 0.126695245887235 no 2984 0.178510305617502 900 54682906
SGTC_949 1165-0505 146 µM -0.924947276942337 0.125725712067052 no 2985 0.177496666475708 912 6244267
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.925051233910304 0.125699874405555 no 2986 0.177469628924116 923 4174840
SGTC_2838 9002687 71.43 µM -0.925465747657416 0.125596887208798 no 2987 0.177361846352947 917 6457060
SGTC_1237 0330-0133 46.1 µM -0.925830270504511 0.125506369068927 no 2988 0.177267096662418 927 X1237 YHR072W ERG7
SGTC_308 4092-1169 104 µM -0.928056605150509 0.12495451488546 no 2989 0.17668910397046 918 2268590 YDL196W YDL196W
SGTC_849 0386-0493 241 µM -0.928149927635015 0.124931419587355 no 2990 0.176664901984349 912 726119
SGTC_1821 st053465 65.6 µM -0.928227647705002 0.124912187825751 no 2991 0.176644747883596 920 675086
SGTC_301 4119-0100 24.5 µM -0.930010477848742 0.124471595922618 no 2992 0.176182829747263 924 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2923 7992654 58.14 µM -0.93026702622506 0.124408284506038 no 2993 0.17611642293365 882 2985126
SGTC_823 0417-1665 178 µM -0.931958776176643 0.123991355603802 no 2994 0.175678915113603 937 3429856
SGTC_82 0054-0107 293.755 µM -0.933172960637047 0.123692725268271 no 2995 0.175365336586549 904 3104697
SGTC_3135 9127742 49.47 µM -0.933563950863695 0.123596667967702 no 2996 0.175264433986785 908 3643468
SGTC_1325 1431-0015 227 µM -0.934979385956604 0.123249365055055 no 2997 0.174899461515372 905 1103340
SGTC_3158 9100007 49.47 µM -0.93714283292882 0.122719846176268 no 2998 0.174342545587284 931 19297233
SGTC_2903 5923464 63.88 µM -0.93923028541708 0.122210442040758 no 2999 0.173806261447855 918 2876576
SGTC_2016 5121758 140 µM -0.940251255192269 0.121961834600527 no 3000 0.173544348203997 903 2795203
SGTC_2222 6885208 172.143 µM -0.942098371441923 0.121512962537597 no 3001 0.173071139108163 919 609514
SGTC_620 0109-0052 432 µM -0.943198265415492 0.121246227005915 no 3002 0.172789750235383 927 493037
SGTC_414 piperonyl butoxide 100 µM -0.945331465363446 0.120730078590482 no 3003 0.172244839587397 916 5794 A potent inhibitor of cytochrome P450.
SGTC_422 cantharidin 155 µM -0.945577077351477 0.120670749831582 no 3004 0.172182170231707 928 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_581 0958-0271 211 µM -0.947676321153022 0.120164504711746 no 3005 0.171647129510604 904 4591145
SGTC_1301 naphtanilide LB 4.81 µM -0.948498447038505 0.11996665255077 no 3006 0.171437881511166 900 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2097 5376186 200 µM -0.948964191633173 0.119854668773973 no 3007 0.171319412275586 911 742755
SGTC_3110 9122132 49.47 µM -0.950253990892995 0.119544933750421 no 3008 0.17099160540703 913 918317
SGTC_1109 tnp00067 928.257 nM -0.951980048140033 0.119131318888927 no 3009 0.170553550307226 921 676295
SGTC_1170 0310-0127 64.8 µM -0.954343074575671 0.118566706998456 no 3010 0.169955005475544 931 774975
SGTC_556 4058-0063 51.5 µM -0.955753530957268 0.118230600879702 no 3011 0.169598385245172 935 6615692
SGTC_3352 9151559 45.5865 µM -0.957834429412543 0.117735962157486 no 3012 0.169073127481583 902 17159339
SGTC_947 3447-0010 211 µM -0.958506857649785 0.117576436545013 no 3013 0.16890361757525 927 748350
SGTC_268 camptothecin 39.6153 µM -0.960684246479275 0.117060927043947 no 3014 0.168355477266187 936 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_499 genistein 192 µM -0.962725550759918 0.116579092759012 no 3015 0.167842635405678 945 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_313 3474-0040 5.03 µM -0.965593778953145 0.115904448521125 no 3016 0.167123744743523 908 1043375 YIL048W NEO1
SGTC_1025 k007-0731 70 µM -0.966735465216079 0.115636682001878 no 3017 0.166838146508317 910 6256118
SGTC_3227 9130768 49.47 µM -0.967720261555174 0.115406065067254 no 3018 0.166592048109342 952 17720899
SGTC_1588 farnesol 29.9 µM -0.968437241505091 0.115238370381453 no 3019 0.166413023888756 914 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_528 3492-0019 172 µM -0.969056094979981 0.115093765874527 no 3020 0.166258600988511 915 2869262
SGTC_2456 5770359 74.46 µM -0.970052485230405 0.114861215356005 no 3021 0.166010165625741 922 3118787
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.970695709370104 0.114711268986262 no 3022 0.165849914556322 934 364106
SGTC_378 3970-0959 8.33 µM -0.972365295246357 0.114322710542708 no 3023 0.165434425365875 930 6615653
SGTC_1312 1218-2183 165 µM -0.973780262889381 0.113994143160406 no 3024 0.165082827502695 908 6744073
SGTC_555 4296-0685 37 µM -0.975585388651531 0.113575955150559 no 3025 0.164634984067088 923 2908540 YHR072W ERG7
SGTC_1571 st070080 73.4 µM -0.976048852241035 0.113468762636427 no 3026 0.16452012799856 910 4315245
SGTC_3323 9138564 53.9225 µM -0.977611927836999 0.113107777569917 no 3027 0.164133147867078 922 43912313 YNL103W MET4
SGTC_2465 5809242 33.21 µM -0.977766021228158 0.113072234841339 no 3028 0.164095030025478 958 2731748
SGTC_69 0096-0274 206.684 µM -0.979759544572991 0.112613133015807 no 3029 0.163602413001527 937 6741392
SGTC_2677 mitomycin C 100 µM -0.980922511479282 0.112345921249815 no 3030 0.163315477661119 955 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_9 0092-0002 10.449 µM -0.981954487385468 0.112109186578922 no 3031 0.163061135284164 929 759368
SGTC_3311 9131146 2.8755 µM -0.983208016835446 0.111822107573966 no 3032 0.162752534982468 919 4900406 YPR165W RHO1
SGTC_1594 piperine 70.1 µM -0.984305659884617 0.111571161217777 no 3033 0.162482623737113 922 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2072 5231554 129 µM -0.987786158718557 0.110778104726438 no 3034 0.161628693850217 920 789545
SGTC_2850 9015429 58.44 µM -0.988309004026623 0.110659320522481 no 3035 0.161500668525048 936 6457570
SGTC_1207 2099-0101 141 µM -0.990522596565725 0.110157430120084 no 3036 0.160959374991519 913 5837381
SGTC_2759 disulfiram 3.38 µM -0.994896032083771 0.109170640297795 no 3037 0.159893416460159 898 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_214 4373-3496 70 µM -0.995908222834268 0.108943164983812 no 3038 0.159647369825574 940 3779166
SGTC_100 0086-0128 49.5915 µM -0.998631687332352 0.108332797763612 no 3039 0.158986572057366 926 93297
SGTC_2996 9066192 71.4286 µM -0.999834002118201 0.108064126316502 no 3040 0.158695423892972 915 6472854
SGTC_2360 9040895 200 µM -1.00020248458488 0.107981880678932 no 3041 0.158606263550151 940 4914414
SGTC_1046 2001-0062 216 µM -1.00058297309449 0.107897002591513 no 3042 0.158514232627204 944 739778
SGTC_286 k060-0067 22.9 µM -1.00116250778379 0.107767814301438 no 3043 0.158374124583282 921 5985051
SGTC_2385 9074692 200 µM -1.0029392358849 0.107372445453836 no 3044 0.157945090098912 921 17046906
SGTC_1904 st060225 78 µM -1.00321942131716 0.107310192374827 no 3045 0.157877502194439 918 66595
SGTC_2166 5933061 31.504 µM -1.00403940589164 0.10712815339001 no 3046 0.15767981004982 929 2877375
SGTC_2370 9071495 200 µM -1.00516626808518 0.106878350136841 no 3047 0.157408397424228 957 21791103
SGTC_1164 k060-0068 93.7 µM -1.00649551110252 0.106584223604772 no 3048 0.157088634941822 918 5963676
SGTC_3316 9136639 10.545 µM -1.00663509332515 0.10655337166086 no 3049 0.157055081868945 914 4903665
SGTC_1189 1431-2119 7.28 µM -1.00757547622715 0.106345686265756 no 3050 0.156829153482508 929 3107275
SGTC_753 1322-0200 289 µM -1.00773552923474 0.106310367378594 no 3051 0.156790721817918 934 5403907
SGTC_2526 patulin 37.61 µM -1.00805099015025 0.106240779442578 no 3052 0.156714992009857 935 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3294 9122953 26.2835 µM -1.0089684921135 0.106038573496552 no 3053 0.156494872585265 937 16459826
SGTC_1274 0865-0114 173 µM -1.01011844659279 0.10578553079274 no 3054 0.156219272707134 914 870624
SGTC_1372 2752-0194 270 µM -1.0113247427272 0.105520559747467 no 3055 0.155930513746109 920 823334
SGTC_2111 5486399 200 µM -1.01147966062371 0.10548656580137 no 3056 0.155893455550301 905 689674
SGTC_107 0358-0022 2.6945 µM -1.01752788960879 0.104165575614893 no 3057 0.15445118584649 968 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_430 0958-0115 16.4 µM -1.01825333794584 0.104007939904419 no 3058 0.154278788722407 936 6833180
SGTC_1966 st070145 16.1 µM -1.02091279824587 0.103431534144014 no 3059 0.153647877506695 941 3748532
SGTC_2355 9061122 103.12 µM -1.0214969110342 0.103305245937768 no 3060 0.153509535921095 961 5302957
SGTC_311 1315-0136 58 µM -1.02201499204794 0.103193327856834 no 3061 0.153386902390469 947 6759207
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.02230627673191 0.103130441972005 no 3062 0.153317981704132 955 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1163 k060-0048 49.9 µM -1.02530593248569 0.10248446031604 no 3063 0.152609428728927 929 6809982
SGTC_2907 7721985 69.9 µM -1.02584577232187 0.102368517812605 no 3064 0.152482143425723 940 3267881
SGTC_1131 3454-3128 32.3 µM -1.02619044104262 0.102294542517598 no 3065 0.152400913102558 909 710982
SGTC_2290 7904846 200 µM -1.02797751897155 0.101911610276194 no 3066 0.151980201383578 937 2962154
SGTC_970 1315-0089 19.5 µM -1.02806058958744 0.101893835444986 no 3067 0.151960663781534 920 6811083 YLR033W RSC58
SGTC_465 cgp-37157 41 µM -1.02886252726053 0.101722358819398 no 3068 0.151772139696599 901 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2088 5278280 127.392 µM -1.02925781917634 0.101637911735697 no 3069 0.151679269427213 943 791502
SGTC_1728 st035614 33.7865 µM -1.02996603386412 0.101486741948349 no 3070 0.151512975247397 926 15945546
SGTC_1240 0356-0016 42.1 µM -1.03081481999092 0.101305782740312 no 3071 0.151313833574533 891 4305613
SGTC_162 k030-0015 37.8 µM -1.03240964645462 0.100966405531736 no 3072 0.15094012742848 955 1809920 YMR134W ERG29
SGTC_3022 9087993 49.47 µM -1.03246855296519 0.100953886186344 no 3073 0.150926335992199 942 17173644
SGTC_303 1348-1668 34.2 µM -1.0345635800315 0.100509367630486 no 3074 0.15043638493583 934 5380509
SGTC_1957 st077035 62.4 µM -1.03466061800751 0.10048881296976 no 3075 0.150413716968972 949 705593
SGTC_470 aa-861 153 µM -1.03546243271975 0.100319089303514 no 3076 0.150226501005171 928 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1723 st034307 2.5525 µM -1.03622473091622 0.100157924363515 no 3077 0.150048655839022 921 867466
SGTC_1302 1159-0335 255 µM -1.03740797361063 0.0999081379479143 no 3078 0.149772881921232 930 649284
SGTC_456 gingerol 170 µM -1.03925240733038 0.099519679787706 no 3079 0.149343681381601 940 442793 A herb.
SGTC_2138 5575593 77.673 µM -1.03941099260715 0.0994863315800269 no 3080 0.149306816891936 941 762213
SGTC_1647 st011722 22.4 µM -1.03989931871555 0.0993836949056567 no 3081 0.149193339516256 924 2854783
SGTC_3326 9140064 16.379 µM -1.04100872441205 0.0991508070793615 no 3082 0.148935749579547 951 1868434
SGTC_181 1447-1644 8.07 µM -1.04264153718468 0.098808771329082 no 3083 0.148557171965531 974 534600
SGTC_2556 citropten 84.59 µM -1.04323701964737 0.0986842469069209 no 3084 0.148419265973273 926 2775 A potential DNA crosslinker.
SGTC_3159 9100096 49.47 µM -1.04636198301688 0.098032652270875 no 3085 0.14769696902111 942 25236875
SGTC_830 4076-0286 57.8 µM -1.04800966055271 0.0976903624993317 no 3086 0.147317077999494 933 6866659
SGTC_2871 9038510 12.99 µM -1.04973042032209 0.09733382684794 no 3087 0.146921036700208 935 4945164
SGTC_901 1112-0062 60.1 µM -1.05007149856301 0.0972632700887351 no 3088 0.146842620750138 923 1908457
SGTC_304 1310-0298 97 µM -1.05621493204802 0.0959988345402547 no 3089 0.145435015146022 944 1550234
SGTC_803 4488-1585 147 µM -1.05838449809478 0.0955551971726278 no 3090 0.144940091948378 930 747204
SGTC_1873 rapamycin 2 nM -1.05878761737468 0.095472932986715 no 3091 0.144848257108512 923 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_630 4356-0227 183 µM -1.05919823203783 0.0953891928266031 no 3092 0.144754755029094 938 779312
SGTC_723 4182-0001 115 µM -1.0596085914441 0.0953055587539595 no 3093 0.144661351694245 945 744821 YLR208W SEC13
SGTC_2908 7930301 100 µM -1.06096500481998 0.0950294965291324 no 3094 0.14435290263655 928 2223178
SGTC_1159 4092-0538 61.2 µM -1.06381351810987 0.0944516747864868 no 3095 0.143706593115787 969 717301
SGTC_2656 pseudo-anisatin 100 µM -1.06486642922488 0.0942387485346526 no 3096 0.143468189338228 988 6708809 A neurotoxin.
SGTC_962 1254-0300 21.5 µM -1.0666711378346 0.0938746129770836 no 3097 0.143060182327286 928 7340576
SGTC_1704 st028805 70.8 µM -1.06911693890776 0.0933827831780815 no 3098 0.142508489924998 950 2876101
SGTC_1165 k072-0275 30.3 µM -1.06935648403209 0.0933347152282493 no 3099 0.142454533881585 947 6153523 YGL055W OLE1
SGTC_560 2332-1943 155 µM -1.06947771024488 0.0933103965258645 no 3100 0.142427233700633 929 21177716
SGTC_2189 6047310 154.431 µM -1.0695711505393 0.0932916550397077 no 3101 0.142406193332526 939 711535
SGTC_3092 9117248 49.47 µM -1.06981372027284 0.0932430153779212 no 3102 0.142351582637455 988 17141857
SGTC_2630 antimycin a 100 µM -1.0703884454435 0.0931278472812404 no 3103 0.142222249017449 967 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_868 0527-0199 213 µM -1.07045893933658 0.0931137283837736 no 3104 0.142206390858799 947 2849450
SGTC_1692 fluoroquinolonic acid 71 µM -1.07475898462363 0.0922554807545582 no 3105 0.141241323960522 941 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2113 5491891 107.031 µM -1.07576884604979 0.0920547738312238 no 3106 0.141015324270378 943 789979
SGTC_2460 5552655 174.22 µM -1.08057167802346 0.091104649229095 no 3107 0.139943843269535 949 5401989
SGTC_1394 3474-0001 65.7 µM -1.08277149463462 0.0906719049813293 no 3108 0.139454930509828 929 5017666 YIL048W NEO1
SGTC_3283 9109332 35.8195 µM -1.08438871057274 0.0903547433454868 no 3109 0.139096243575255 919 17027281
SGTC_1393 3470-5649 58.2 µM -1.08565491269612 0.0901069966771299 no 3110 0.138815847668309 938 4108395
SGTC_2155 5570423 76 µM -1.08571176543325 0.0900958846510724 no 3111 0.1388032668704 969 797402
SGTC_1442 4112-3290 3 µM -1.0859056601226 0.0900579950501396 no 3112 0.138760366246886 974 704353
SGTC_300 r073-0011 5.04 µM -1.0921628636643 0.088841601593665 no 3113 0.137380761110523 952 2735780
SGTC_509 pifithrin 175 µM -1.09396999056328 0.0884925851424103 no 3114 0.136984070007137 980 4817 A p53 inhibitor.
SGTC_3280 9140961 49.47 µM -1.1007829962805 0.0871859497462936 no 3115 0.135495556957229 970 4901226
SGTC_2832 7992762 51.95 µM -1.10093474674482 0.0871570111201634 no 3116 0.135462529018572 942 2985177
SGTC_178 4092-0806 87.505 µM -1.10164891428949 0.0870209165562342 no 3117 0.135307167121614 929 2169044
SGTC_1741 st038134 10.228 µM -1.10187976233482 0.0869769592126187 no 3118 0.135256973958708 973 1272587
SGTC_2031 5180455 200 µM -1.1041335659982 0.0865486682912612 no 3119 0.134767601317372 984 29949
SGTC_2238 6671620 73.2395 µM -1.10689482147087 0.0860260975302423 no 3120 0.134169702547909 933 729941
SGTC_216 k038-0035 28.382 µM -1.10737420423739 0.0859356148063082 no 3121 0.134066086996621 956 4444231 YPR107C YTH1
SGTC_1859 st055998 20 µM -1.11254914090356 0.084963383710591 no 3122 0.132951056931201 967 676301
SGTC_1321 1326-2144 215 µM -1.11488631273726 0.0845270045732919 no 3123 0.132449571381269 965 3513030
SGTC_2715 st079500 56.4 µM -1.11778132270262 0.083988803947267 no 3124 0.131830200169563 949 28246688
SGTC_1168 k815-0004 80.5 µM -1.1189331370196 0.0837753913869879 no 3125 0.131584332446805 965 642433
SGTC_1880 MG-132 525 µM -1.11897041596658 0.0837684910125016 no 3126 0.131576380127115 946 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2356 9061756 188.97 µM -1.11919609897192 0.0837267259531357 no 3127 0.131528244664104 951 20104043
SGTC_2100 5377183 190 µM -1.1216694206179 0.0832700358892525 no 3128 0.131001511511024 932 2844202
SGTC_818 4072-2707 53.5 µM -1.12351230367598 0.082930973504129 no 3129 0.130609989050018 948 882871
SGTC_544 k015-0020 52.4 µM -1.12720019260703 0.0822555784766009 no 3130 0.129828924542037 955 3008304
SGTC_1932 st074806 40.9 µM -1.13442074080422 0.0809452252423036 no 3131 0.128309051518688 953 17251235
SGTC_616 4092-0450 108 µM -1.13656481581591 0.0805591782529378 no 3132 0.12786012774431 976 787165
SGTC_1822 st052468 42 µM -1.14182963023237 0.0796171350243156 no 3133 0.126762421741036 961 2873678
SGTC_2502 avocadyne acetate 18.59 µM -1.14513901270324 0.079029261625555 no 3134 0.126075788498031 948 3952079
SGTC_1870 st057514 26.5 µM -1.15417199851681 0.0774413924931999 no 3135 0.124214830072816 961 5393161
SGTC_2300 7976697 71.57 µM -1.15523958180986 0.0772553392282368 no 3136 0.123996164932489 945 2236109
SGTC_2417 cerulenin 830 nM -1.15552968213886 0.0772048406663229 no 3137 0.123936792413901 958 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1669 st015249 58.4 µM -1.15870365245584 0.0766539760654277 no 3138 0.123288500767112 977 722793
SGTC_3279 9140807 49.47 µM -1.16086187879379 0.0762811116490145 no 3139 0.122849036888817 982 45595718
SGTC_1262 0737-0114 49.6 µM -1.16122884894553 0.0762178498427944 no 3140 0.122774422839762 969 765919
SGTC_1148 3909-7663 27.7 µM -1.16174339785591 0.0761292142625913 no 3141 0.122669855937679 991 4084526
SGTC_1998 st075797 76.8 µM -1.16786147042288 0.0750813269459703 no 3142 0.121431323977951 939 24208315
SGTC_2710 st078562 53.7235 µM -1.16955288606665 0.0747935755066803 no 3143 0.121090473332152 984 17250908
SGTC_2624 nerol 100 µM -1.17051864199903 0.074629654447194 no 3144 0.120896158287992 972 637566 A natural product oil.
SGTC_2109 5483026 200 µM -1.1708225336698 0.0745781306271434 no 3145 0.120835059138425 970 759335
SGTC_2982 9019404 25.97 µM -1.17366874414546 0.0740968822996994 no 3146 0.120263867138645 952 22333232
SGTC_433 pimozide 108 µM -1.17390716891925 0.0740566764476347 no 3147 0.120216105335104 977 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2892 9047358 58.44 µM -1.17762026278864 0.0734326819209834 no 3148 0.119474014048138 982 6466771
SGTC_816 0325-0417 81.3 µM -1.17978365451597 0.0730709771251644 no 3149 0.11904313608479 957 68101
SGTC_2622 2-methoxyxanthone 59.94 µM -1.18286327916338 0.0725584381850335 no 3150 0.118431668430981 973 71034 A hepatoprotective.
SGTC_1197 1601-0112 267 µM -1.18381097146831 0.0724012700327857 no 3151 0.118243949089599 975 7350313
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.18635573662466 0.0719805290822466 no 3152 0.117740922039522 997 91467 include heat shock
SGTC_2453 5731132 22.18 µM -1.18724699124791 0.0718336168201787 no 3153 0.117565105176779 988 1362040
SGTC_1995 st072814 61.1 µM -1.18738155431959 0.0718114557634316 no 3154 0.117538576218556 985 5769371
SGTC_1681 tripelennamine 100 µM -1.1895841348284 0.0714494599232272 no 3155 0.117104942277341 935 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2409 alverine citrate 63.97 µM -1.193402261117 0.0708252679950815 no 3156 0.116355934938096 952 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_289 k017-0060 526 µM -1.19759606294214 0.0701444974814951 no 3157 0.115537154783359 980 5512909
SGTC_2153 5569715 200 µM -1.19981903541307 0.0697856942150996 no 3158 0.115104814836565 988 2054701
SGTC_1389 3405-0187 19 µM -1.20090228246309 0.0696113632854922 no 3159 0.114894554392959 960 799890
SGTC_2481 5478948 45.16 µM -1.20334295794148 0.0692198053764037 no 3160 0.114421815933539 981 77792
SGTC_1868 st057644 42.7 µM -1.20460806136426 0.0690175135221539 no 3161 0.114177321598809 998 688665
SGTC_1740 st038286 13.222 µM -1.2091391986207 0.0682967152025048 no 3162 0.113304685948676 955 716786
SGTC_3163 9099914 49.47 µM -1.20938868209242 0.0682571975705688 no 3163 0.11325677737418 1003 16268368
SGTC_2019 4016004 108 µM -1.21040239127974 0.0680968097708003 no 3164 0.113062262384606 975 45595336
SGTC_1754 st042065 16.137 µM -1.21222449889194 0.0678092498410496 no 3165 0.112713227965621 943 1126236 YIL048W NEO1
SGTC_1853 st056710 91.2 µM -1.21443156033496 0.0674621946594721 no 3166 0.112291484868174 977 269167
SGTC_1960 st011366 51.8 µM -1.21621427967643 0.0671828698041246 no 3167 0.111951652715384 968 3972846
SGTC_2956 9076196 2.52 µM -1.2177207830446 0.0669475216345498 no 3168 0.11166504824295 994 16423868
SGTC_688 0527-0193 473 µM -1.21859299661252 0.0668115549416706 no 3169 0.111499354247008 1004 4007154
SGTC_3356 9151811 4.48 µM -1.21941609396816 0.0666834408641936 no 3170 0.111343152264867 984 1859254 YPR165W RHO1
SGTC_1826 st055655 41.6 µM -1.2197424920784 0.0666326900802874 no 3171 0.111281253979679 989 676168
SGTC_1181 1222-0449 220 µM -1.22415184150986 0.0659500181340224 no 3172 0.110447476243525 987 658318
SGTC_681 1642-0006 26.6 µM -1.22864849096114 0.065259424580429 no 3173 0.109601813155116 1013 4446530
SGTC_2575 plumbagin 510 nM -1.2298369853112 0.0650778367937898 no 3174 0.109379077609153 964 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_246 cycloheximide 667 µM -1.22989520239358 0.065068952001599 no 3175 0.109368175514008 975 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3241 9133421 49.47 µM -1.23390411739843 0.0644593934328431 no 3176 0.108619317544514 1023 17018221
SGTC_895 0964-0006 13.7 µM -1.23465659765851 0.0643454743545196 no 3177 0.108479167689587 990 6738897
SGTC_1460 k062-0059 9.15 µM -1.23871914933835 0.0637331391756707 no 3178 0.107724762258604 958 1373085
SGTC_2467 5474540 200 µM -1.23933035641036 0.0636414075387962 no 3179 0.10761159056087 956 5413519
SGTC_357 1325-0123 420 µM -1.2403350333809 0.0634908461099921 no 3180 0.107425749781877 1003 1098503
SGTC_2470 5664817 21.68 µM -1.24190994922938 0.0632553864403655 no 3181 0.107134894414663 996 2859561
SGTC_3130 9127414 49.47 µM -1.24199754587376 0.0632423101855482 no 3182 0.107118733759373 988 1494646
SGTC_1310 1188-0297 994 nM -1.24737751211935 0.0624432262986433 no 3183 0.106129554087024 957 1588352
SGTC_1847 st056231 15 µM -1.24774766048554 0.062388539108434 no 3184 0.106061740730016 970 5393180
SGTC_432 NS 1619 61.3 µM -1.24867354368929 0.0622519089956691 no 3185 0.105892250594093 969 4552 A K+/calcium channel activator.
SGTC_1777 st045864 34.765 µM -1.25065929172706 0.0619596645667223 no 3186 0.105529404250537 1012 4691462
SGTC_2358 9037157 4 µM -1.25134308956288 0.0618592775781129 no 3187 0.105404665469308 970 2388925
SGTC_231 b-estradiol 524 µM -1.25368605079344 0.061516274606507 no 3188 0.104978070030469 992 450 A steroid.
SGTC_3335 9143315 29.6265 µM -1.25789496658787 0.0609038340704383 no 3189 0.104214872141322 962 4899691
SGTC_1914 st062367 72.6 µM -1.2592367085619 0.0607096021208016 no 3190 0.103972423098364 970 978205
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.25936602400071 0.0606909079103746 no 3191 0.103949077786592 983 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1816 st051957 91.6 µM -1.2604781613961 0.0605303199548016 no 3192 0.103748460573193 1012 674121
SGTC_3053 9095903 49.47 µM -1.2609384003356 0.0604639607235348 no 3193 0.103665520811995 1022 17174018
SGTC_3134 9127454 49.47 µM -1.26351732254247 0.0600931732055617 no 3194 0.103201662619706 1002 24262820
SGTC_1943 st076331 65.2 µM -1.26358696036694 0.0600831856886198 no 3195 0.103189158135272 992 24208415
SGTC_741 4582-0002 126 µM -1.26556588891247 0.0597999089484836 no 3196 0.102834272481236 974 2912688
SGTC_781 4335-2806 94.4 µM -1.26908769136793 0.0592983642222562 no 3197 0.102204894888961 1025 845254
SGTC_1975 st070967 30.8 µM -1.27105520483594 0.059019607383004 no 3198 0.10185450494863 986 261391
SGTC_2000 st075254 36.4 µM -1.27466666479979 0.0585106129254871 no 3199 0.101213625279378 970 17234175
SGTC_1474 0330-0125 5.35 µM -1.27479217325294 0.058492986097016 no 3200 0.101191405851553 1020 X1474
SGTC_2154 5570129 200 µM -1.27530932144856 0.0584204000519213 no 3201 0.101099889858147 1022 673366
SGTC_2414 st077232 92.9 µM -1.27907890249739 0.0578934430456029 no 3202 0.100434636081195 974 729801
SGTC_1836 st055642 81 µM -1.2804274421466 0.0577058380799092 no 3203 0.100197423912152 978 8571
SGTC_3206 9114350 49.47 µM -1.29056433875538 0.056310884405925 no 3204 0.0984273942313884 981 17087243
SGTC_1774 st048371 48.465 µM -1.29143812105124 0.0561918971976176 no 3205 0.0982758995291784 997 4242727
SGTC_2250 alverine citrate 130 µM -1.29431064899507 0.0558021276756213 no 3206 0.0977790698111774 957 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2333 9017922 200 µM -1.30021023281191 0.0550083125705457 no 3207 0.0967644622076265 978 3163164
SGTC_2992 9074591 71.4286 µM -1.30060747316495 0.0549551844070831 no 3208 0.0966964238655966 995 17741321
SGTC_1695 st026914 34.495 µM -1.30218835323579 0.0547441542594628 no 3209 0.0964260027983384 1004 3289191
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.30712353126427 0.0540894816302019 no 3210 0.095585380338195 973 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_94 0334-0113 514.748 µM -1.30975090347497 0.0537434856030789 no 3211 0.0951400585403994 983 6795178
SGTC_3005 9076496 71.4286 µM -1.3119737346219 0.0534521340182039 no 3212 0.0947644984227255 994 21368410
SGTC_2674 ligustilide 100 µM -1.32129275829743 0.0522442674713007 no 3213 0.0932018838358215 1005 5319022 A signalling regulator.
SGTC_921 1561-0023 372 µM -1.3242427997093 0.0518664535203819 no 3214 0.0927112103406921 988 24050882
SGTC_2394 5221648 200 µM -1.33310970019137 0.0507439220858466 no 3215 0.0912479032827093 1007 788586
SGTC_1898 st060199 18.6 µM -1.33678696710136 0.0502841004097698 no 3216 0.0906460922791605 980 688866
SGTC_711 k292-0785 179 µM -1.34273001820806 0.0495479820352321 no 3217 0.0896797054849262 981 4146315
SGTC_2197 6588183 93.1375 µM -1.34274287850682 0.0495463985087566 no 3218 0.0896776226376685 987 884136
SGTC_2450 5739737 12.93 µM -1.3489553005669 0.0487861548803157 no 3219 0.0886756619868703 990 2262825
SGTC_1245 0418-0076 17.2 µM -1.35302881672294 0.0482927403680757 no 3220 0.0880232122582715 1024 6790114
SGTC_2425 5628681 7.85 µM -1.35702250197834 0.0478128789516813 no 3221 0.0873870304018753 1007 5714958
SGTC_104 0074-0074 590.992 µM -1.35873864537452 0.0476078518703369 no 3222 0.0871147107451237 996 3943124
SGTC_2381 9035592 200 µM -1.35990613340944 0.0474687753828439 no 3223 0.0869298149167122 1015 4749657
SGTC_2120 5538279 151.968 µM -1.36262705677609 0.0471459098059872 no 3224 0.0865000385769848 1017 2058197
SGTC_1199 1638-0010 4.46 µM -1.36625480064963 0.0467181815567454 no 3225 0.0859295012321847 993 3111136
SGTC_3229 9132204 49.47 µM -1.36861589418466 0.046441473881147 no 3226 0.0855596865182092 1027 17682924
SGTC_1278 0874-0585 172 µM -1.37141688646076 0.0461149201388538 no 3227 0.0851225181878337 1014 766306
SGTC_2911 7942208 15.64 µM -1.3754545181629 0.045647440922503 no 3228 0.084495288475195 977 1243384
SGTC_870 0573-2213 57.6 µM -1.37580889285964 0.0456065937408657 no 3229 0.0844404037546442 1002 3916321
SGTC_3184 9108758 49.47 µM -1.38111956587396 0.0449979692508207 no 3230 0.0836211002787291 1010 902885
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.38400766715541 0.0446697357163196 no 3231 0.0831780535371807 1021 61125 An anti-inflammatory.
SGTC_1833 st055984 71 µM -1.38409302401969 0.0446600643003974 no 3232 0.0831649863452171 1005 676288
SGTC_2964 9083345 53.42 µM -1.38721599810789 0.0443073717761157 no 3233 0.0826879542907255 975 17741579
SGTC_2802 7925815 54.55 µM -1.39191053409303 0.0437814222023116 no 3234 0.0819747457640692 998 1262923
SGTC_1956 st077085 54 µM -1.39646356981433 0.043276148225143 no 3235 0.0812874718006373 1011 24208685
SGTC_1485 3909-9022 254 µM -1.40007613509312 0.0428786023856841 no 3236 0.080745260326754 1029 714516
SGTC_693 4161-2696 114 µM -1.40556507057625 0.0422802246903079 no 3237 0.0799266571255635 1021 805759
SGTC_353 1988-1175 58.3 µM -1.41773834829401 0.0409772488000721 no 3238 0.0781335848196624 985 2788357
SGTC_126 0417-1624 672.48 µM -1.42254647269402 0.0404716637677761 no 3239 0.0774338352155656 1001 41912 YDL195W SEC31
SGTC_412 gemfibrozil 100 µM -1.4228041595593 0.0404447110456464 no 3240 0.0773964676129278 1004 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_838 0109-0203 71.4 µM -1.42809203385877 0.0398948373445949 no 3241 0.0766326850530497 1005 759422
SGTC_2755 lomerizine 42.69 µM -1.42836352601845 0.0398667703155824 no 3242 0.0765936258924396 991 3949 A calcium channel blocker.
SGTC_515 4092-1064 102 µM -1.4284641732521 0.039856369420558 no 3243 0.07657914977713 1030 717353
SGTC_2086 5274770 176.623 µM -1.4345863579995 0.0392278383034713 no 3244 0.0757025021579905 1001 689278
SGTC_1481 3346-2004 36 µM -1.43523179179339 0.0391620478299748 no 3245 0.0756105285102911 1031 2770522
SGTC_1919 st067113 52.3 µM -1.43751849488055 0.0389296816197931 no 3246 0.0752853607347726 1010 1268243
SGTC_1003 4049-0218 100 µM -1.43914754010275 0.0387648299368854 no 3247 0.0750543625114378 1014 295161
SGTC_2106 5357045 167.29 µM -1.45108566568846 0.0375740286961778 no 3248 0.0733780037433436 1018 668842
SGTC_896 0964-0007 44.5 µM -1.45341408695054 0.037345290898455 no 3249 0.0730544087825699 992 6756758
SGTC_1185 1319-0113 81.3 µM -1.45834114016892 0.0368650200583487 no 3250 0.0723732679071543 1022 4672763
SGTC_1288 0973-0013 65.5 µM -1.45963871263947 0.036739381129263 no 3251 0.0721946969197371 1030 4315430
SGTC_626 0214-0009 33 µM -1.47591695252423 0.0351927744009854 no 3252 0.0699830939717798 1015 3437874
SGTC_820 1582-0060 59.9 µM -1.48006980765139 0.0348068783971737 no 3253 0.069427309009323 1020 3848840
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.48185381377164 0.0346421732645379 no 3254 0.0691895983002105 1044 279621
SGTC_2163 5671233 125 µM -1.48352007443434 0.034488917428122 no 3255 0.0689681434817073 990 701023
SGTC_636 0kpi-0074 126 µM -1.48481605644742 0.0343701037852731 no 3256 0.0687962786809255 1020 616434
SGTC_1933 st074711 15.9 µM -1.48496023779535 0.0343569062773384 no 3257 0.0687771787077437 1018 17250958
SGTC_1926 methyl fluorone black 53.6 µM -1.48591460866969 0.0342696537904529 no 3258 0.0686508544978652 962 72721 Reacts with homocysteine.
SGTC_232 clozapine 119 µM -1.48592566994966 0.0342686435916945 no 3259 0.0686493914338811 1026 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1471 k673-0312 37 µM -1.48825639606364 0.0340563295530616 no 3260 0.0683416447450627 1016 24099884
SGTC_2904 7225135 42.03 µM -1.49100366185849 0.0338074615684838 no 3261 0.0679802667536399 1050 4446116
SGTC_2790 5423970 71.43 µM -1.50537318360888 0.0325300276526116 no 3262 0.0661140797426868 1009 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_957 1187-1561 14.1 µM -1.52892474345461 0.030522588452379 no 3263 0.063141550712974 1014 1538454
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.53108353479597 0.0303438307233716 no 3264 0.062874374297004 1023 5355888
SGTC_1674 st016616 23.6 µM -1.53476767745687 0.0300407708644704 no 3265 0.0624204525161563 1012 625830
SGTC_2105 5350118 200 µM -1.5440290219086 0.0292899971595809 no 3266 0.0612906510203927 1025 2133313
SGTC_347 4534-1311 26.2 µM -1.5551589569252 0.0284084286119504 no 3267 0.0599541082473318 1028 2862016
SGTC_1206 3978-0017 132 µM -1.55935963905917 0.0280814954209864 no 3268 0.0594556417112659 1005 3873677
SGTC_3172 9105863 49.47 µM -1.56833444619875 0.0273934882416282 no 3269 0.0584015505073606 1063 2348785
SGTC_99 0109-0120 622.8 µM -1.57603997389222 0.026814053238608 no 3270 0.05750829556604 1015 759414
SGTC_1879 gemcitabine 100 µM -1.58897252379311 0.0258645744774133 no 3271 0.0560332980324888 1035 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3169 9102970 49.47 µM -1.60059755627607 0.025035258446318 no 3272 0.0547330419380077 1065 17027839
SGTC_2872 9044037 25.97 µM -1.60094867936949 0.0250105606526359 no 3273 0.054694143229765 1047 6465195
SGTC_34 0469-0683 81.75 µM -1.60128019646909 0.0249872606838198 no 3274 0.0546574366089265 1024 3690923
SGTC_805 3852-0218 479 µM -1.60589664972684 0.0246646899219553 no 3275 0.0541483098895767 1029 6615355
SGTC_1925 st057770 10.1 µM -1.6180085369676 0.0238349520904643 no 3276 0.0528303789431093 1022 5989122
SGTC_2486 5283202 22.39 µM -1.62761791097741 0.0231934594793609 no 3277 0.0518029644421458 1021 1377751
SGTC_2775 cyproheptadine 69.59 µM -1.63849547945073 0.0224849067178445 no 3278 0.0506591881441074 1033 2913 A selective serotonin reuptake inhibitor.
SGTC_1724 st037281 8.293 µM -1.64343725831169 0.0221690855566639 no 3279 0.050146248330418 1013 574124 YDL195W SEC31
SGTC_2591 skatole 100 µM -1.64490912722525 0.022075747424634 no 3280 0.0499942762049921 1035 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_215 1287-0124 461.5 µM -1.6464120721981 0.0219807811183958 no 3281 0.0498394746509114 1051 5560863
SGTC_3211 9128781 49.47 µM -1.66230694280076 0.0209973772337904 no 3282 0.0482256232217262 1016 17194361
SGTC_924 2046-0044 21.3 µM -1.66909482079866 0.0205889046281007 no 3283 0.0475492947839417 1033 3623589
SGTC_2855 9016525 58.44 µM -1.67056852216644 0.0205011169950593 no 3284 0.0474034671732447 1031 43811474
SGTC_2990 9074105 71.4286 µM -1.68523634099834 0.01964451945782 no 3285 0.0459714911082931 1049 6502001
SGTC_1999 st074831 12.5 µM -1.69081740140685 0.0193266651120392 no 3286 0.0454358413117897 1038 17112523
SGTC_2291 7917025 104.35 µM -1.69580259441399 0.0190464525374542 no 3287 0.0449616355021046 1034 2964612
SGTC_2706 st078239 82.5 µM -1.7029690178936 0.018649692910438 no 3288 0.044286933281119 1055 15434492
SGTC_533 1222-0222 6.71 µM -1.70914347099935 0.0183135155514556 no 3289 0.043712188468064 1050 3982874
SGTC_624 k048-0052 28 µM -1.72437639294977 0.0175061464183976 no 3290 0.0423199582081793 1053 6835531
SGTC_2399 5884133 200 µM -1.73934446616747 0.016742612369944 no 3291 0.0409870951052885 1050 722445
SGTC_2580 diallyl disulphide 81.36 µM -1.74403843229647 0.0165091145521281 no 3292 0.040576194256298 1040 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1342 1486-1464 234 µM -1.74691090745146 0.0163676047128673 no 3293 0.0403263967488943 1047 3253938
SGTC_504 lovastatin 124 µM -1.75544625877916 0.0159532315872616 no 3294 0.0395915027110674 1054 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3171 9103192 49.47 µM -1.75811649734232 0.0158254580802483 no 3295 0.0393638446483403 1065 13018434
SGTC_2387 9077560 195.08 µM -1.76094717803647 0.0156909665600836 no 3296 0.039123671884833 1037 5303272
SGTC_1241 0364-0022 50.8 µM -1.76617869661071 0.0154449858861678 no 3297 0.0386829369546176 1050 4563895
SGTC_566 0958-0068 16.5 µM -1.77484152792737 0.015044947019527 no 3298 0.0379620286127113 1030 6815365
SGTC_3285 9112818 20.8695 µM -1.77724446310391 0.0149355726248348 no 3299 0.0377640133952796 1049 17017947 YPR165W RHO1
SGTC_1848 st056003 16.4 µM -1.78729419679786 0.0144855155357628 no 3300 0.036944975741086 1037 146492
SGTC_3321 9137793 26.8275 µM -1.81927191781771 0.0131302845379281 no 3301 0.0344349777491798 1051 4904192
SGTC_2389 9091542 195.52 µM -1.84771698604077 0.0120182820336844 no 3302 0.0323216476981322 1047 3626624 YOL127W RPL25
SGTC_2874 9043904 71.43 µM -1.86529297159293 0.0113727953386515 no 3303 0.0310701748923404 1045 4463428
SGTC_1228 0124-0032 52.5 µM -1.89218025914955 0.0104436516510952 no 3304 0.0292334838268507 1059 X1228
SGTC_954 1189-0853 2.85 µM -1.89877658911051 0.010226072415632 no 3305 0.0287969282695554 1039 2828194
SGTC_1709 st033179 39.1045 µM -1.8999426146689 0.0101880251854422 no 3306 0.0287203254065374 1052 573381
SGTC_2098 5376439 882.5 nM -1.90267064544093 0.0100994920310938 no 3307 0.0285417672909249 1059 2844116
SGTC_1112 tnp00069 1.16933 µM -1.90835787689474 0.00991707961526968 no 3308 0.0281724886224955 1055 145826
SGTC_361 000s-0510 1.45 µM -1.92247156985166 0.00947677281334728 no 3309 0.0272732237935913 1042 660
SGTC_3123 9126162 49.47 µM -1.92668583646974 0.00934865798978904 no 3310 0.0270093970172958 1045 25239884
SGTC_1986 st071812 45 µM -1.95259958729508 0.00859367987590977 no 3311 0.0254335300560796 1070 11838594
SGTC_244 nsc-207895 1.295 µM -1.9644035551874 0.00826788679388661 no 3312 0.0247416554436162 1050 42640
SGTC_2371 9071574 200 µM -1.96964256901529 0.00812679851728034 no 3313 0.0244396746423204 1074 45596039
SGTC_2762 leflunomide 42.06 µM -1.97209567877377 0.00806146589363471 no 3314 0.0242993425886696 1069 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1356 1502-0781 85.8 µM -1.9812677271195 0.00782126273559682 no 3315 0.0237806287839446 1069 567702
SGTC_1852 st056254 31.4 µM -1.9947661365856 0.00747921235571701 no 3316 0.0230341961584693 1067 442583
SGTC_836 0330-0104 1.35 µM -1.99659346941045 0.00743393536394955 no 3317 0.0229346814304334 1054 46494820
SGTC_582 0987-0078 156 µM -2.00084117735846 0.00732961924334941 no 3318 0.0227047541564144 1071 1625765
SGTC_750 4073-0104 132 µM -2.00722899166467 0.00717517504315823 no 3319 0.0223626429926329 1001 22330957
SGTC_787 4152-0075 138 µM -2.00726779524209 0.0071742456916221 no 3320 0.02236057815653 1048 9566539
SGTC_909 3448-9333 149 µM -2.01889565130378 0.00690049471259713 no 3321 0.0217490331614223 1065 3344074
SGTC_772 k072-0172 35.3 µM -2.04619684466217 0.0062937027886222 no 3322 0.020368503835711 1049 5861980
SGTC_1857 st056007 79.3 µM -2.05123942089 0.0061869461210735 no 3323 0.0201218183354027 1075 619834
SGTC_1260 0700-1617 7.75 µM -2.05897724506498 0.00602624626448812 no 3324 0.0197482091877977 1058 2853078
SGTC_1265 0819-1001 68.8 µM -2.0690759827587 0.00582208542850237 no 3325 0.0192694785467727 1072 3106768
SGTC_1684 st024538 14.6195 µM -2.07480517761204 0.00570901019252401 no 3326 0.019002297268716 1071 6732859
SGTC_209 4077-0173 175.592 µM -2.08703104126642 0.00547420912869017 no 3327 0.0184426643444415 1074 15993494
SGTC_1349 flufenamic acid 69 µM -2.1142963354735 0.00498122613745341 no 3328 0.0172449825819055 1068 3371 A non-steroidal anti-inflammatory.
SGTC_3325 9138760 55.175 µM -2.13513246725987 0.00463156440060288 no 3329 0.0163750956343047 1057 43844959
SGTC_1842 st055362 61.2 µM -2.15815050418456 0.00427089637639656 no 3330 0.01545806609625 1077 676032
SGTC_1781 st038725 66.3 µM -2.19658229590405 0.00372437569782413 no 3331 0.0140251458868822 1072 4270275 YIL048W NEO1
SGTC_757 1066-0008 322 µM -2.21052692898155 0.00354214575197602 no 3332 0.0135343068592323 1063 6842497
SGTC_1915 st067105 30.6 µM -2.21552426728315 0.00347881464952688 no 3333 0.0133620502837303 1062 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_583 1488-1091 88.9 µM -2.24932183019005 0.00307654141353834 no 3334 0.0122460139576114 1086 4303273
SGTC_1111 tnp00062 510.699 nM -2.29616391554507 0.00258823598489935 no 3335 0.010833255450421 1076 676306
SGTC_771 0250-0039 27.3 µM -2.31591778151785 0.00240419475589487 no 3336 0.0102813791284728 1077 3005115
SGTC_496 calpeptin 138 µM -2.37572028424673 0.00191694319182891 no 3337 0.00875736720872578 1074 73364 A calpain inhibitor.
SGTC_2878 9043973 25.97 µM -2.39598266626792 0.00177341818255175 no 3338 0.00828793708965642 1082 6465167
SGTC_1249 0481-0015 10.2 µM -2.50938692645789 0.00113562018736172 no 3339 0.00604704643767345 1071 4227577
SGTC_2521 angolensin 13.4 µM -2.52957079897795 0.00104711015288879 no 3340 0.00571010654863454 1081 821428 A flavenoid.
SGTC_2482 5981709 142.65 µM -2.55930771969606 0.000928191763723749 yes 3341 0.00524404288216016 1076 877755
SGTC_1290 0986-0249 10.2 µM -2.57661928273913 0.000864809587947906 yes 3342 0.00498858871916884 1079 53329
SGTC_1784 st039334 36.3 µM -2.66291575721524 0.000604191862440051 yes 3343 0.00387334027123189 1077 3496984
SGTC_1910 st062352 60.4 µM -2.69122043968947 0.000535967056468031 yes 3344 0.00355955684292717 1082 2245730
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.70615947765788 0.00050290189718262 yes 3345 0.00340331748029708 1082 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_174 3553-0389 74.3 µM -2.71379994405116 0.000486730549015429 yes 3346 0.00332581609527084 1088 738071
SGTC_508 roscovitine 141 µM -2.75446535836162 0.000408470210744692 yes 3347 0.00293940565158702 1094 160355 A CDKinase inhibitor.
SGTC_755 1995-0008 37.3 µM -2.81172100138289 0.000317921642553357 yes 3348 0.0024638612806717 1092 689533
SGTC_578 3460-0051 92 µM -2.82588566147019 0.000298603508500182 yes 3349 0.00235750454919576 1090 2876744
SGTC_912 3474-0017 2.18 µM -2.95130478597971 0.00016937575998597 yes 3350 0.0015821725008163 1086 3360550
SGTC_2993 9054257 71.4286 µM -3.02957174239234 0.000117613117007275 yes 3351 0.00122450365508405 1081 6470217 YGL055W OLE1
SGTC_2484 5809818 12.04 µM -3.16864671330482 6.02564229936572e-05 yes 3352 0.000765752153695269 1088 2870548
SGTC_758 0868-0029 16 µM -3.94147689065374 9.00869803527978e-07 yes 3353 4.04907191318888e-05 1085 762687
SGTC_3203 9113543 49.47 µM -4.03815040773771 5.02296674593228e-07 yes 3354 2.6937153637902e-05 1093 17018012
SGTC_3062 9077494 49.47 µM -4.70739674215974 6.1481939650497e-09 yes 3355 1.25450149509984e-06 1022 16459633
SGTC_1107 amlodipine 47 µM -4.79832971070484 3.21983258371644e-09 yes 3356 7.99971258960687e-07 1078 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.