SGTCid condition conc unit YER181C|YER181C.score YER181C|YER181C.strain.pval YER181C|YER181C.strain.significant YER181C|YER181C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3055 9094636 49.47 µM 8.67977828594899 2.41425705447817e-19 yes 1 1.98270535819468e-18 1 25236176
SGTC_825 1988-2224 89.6 µM 5.66373178277507 2.94105028372267e-09 yes 2 7.4057933710687e-09 18 1180859
SGTC_2212 7123476 200 µM 5.61570281605242 3.94544683789408e-09 yes 3 9.78824393441793e-09 1 1085715
SGTC_344 k064-0035 6.43 µM 5.33510019054768 2.09410819697562e-08 yes 4 4.77459076521716e-08 8 5088750
SGTC_2071 5230951 39.92 µM 4.81852119918176 3.66437959136542e-07 yes 5 7.23130805431991e-07 9 1799272
SGTC_709 3807-1509 243 µM 4.81230974544649 3.78640308051534e-07 yes 6 7.45979399184975e-07 6 1886677 YPL242C IQG1
SGTC_965 1291-5240 308 µM 4.64596792362041 8.97144403462791e-07 yes 7 1.6924279950216e-06 16 2834598
SGTC_3008 9078912 71.4286 µM 4.36250843566796 3.65712321239731e-06 yes 8 6.42898133397186e-06 7 16648731
SGTC_2907 7721985 69.9 µM 4.27801746038792 5.47271525860466e-06 yes 9 9.42826166904224e-06 14 3267881
SGTC_3207 9114163 49.47 µM 4.1387003273834 1.0471747319667e-05 yes 10 1.74639408209e-05 25 849233
SGTC_1153 4055-0057 267 µM 3.76127968290425 5.50563985702431e-05 yes 11 8.45231405941731e-05 32 882706
SGTC_1268 0828-0275 2.46 µM 3.73663095079864 6.10548315760913e-05 yes 12 9.32511704724732e-05 26 745337
SGTC_343 4130-2827 29.8 µM 3.55733700182925 0.000127194098932337 yes 13 0.000187316707650228 42 1118244
SGTC_1106 tegaserod maleate 11.7 µM 3.5468736343808 0.000132628851250307 yes 14 0.000194915763338454 40 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1147 3809-1045 12.3 µM 3.53306117002628 0.000140136930335524 yes 15 0.000205388707700249 36 325925
SGTC_2380 9035439 200 µM 3.51435139238996 0.000150943553597639 yes 16 0.000220414625025035 43 6462575
SGTC_1668 st014914 51.6 µM 3.46596928345781 0.000182616250209604 yes 17 0.000264161817231857 9 2839556
SGTC_117 lucigenin 22.078 µM 3.44030912291584 0.00020183805163783 yes 18 0.000290525063708118 113 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1843 st055809 45.5 µM 3.38782689154719 0.000247179669434655 yes 19 0.000352243561279877 35 16413835
SGTC_3065 9113888 49.47 µM 3.37124861219819 0.00026337014034233 yes 20 0.000374141483123733 44 16648368
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 3.30116792205254 0.000343348156054564 yes 21 0.000481416188545737 49 6708760
SGTC_1958 st076513 41.9 µM 3.20551500517927 0.000489233878941817 yes 22 0.000674105085747363 69 732122 YGL099W LSG1
SGTC_3181 9108277 49.47 µM 3.20135370138883 0.000496726638664374 yes 23 0.000683917575481426 45 17097298
SGTC_1502 4534-4282 27.7 µM 3.19907389332656 0.000500876524883603 yes 24 0.00068934913245834 35 3278949
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.17887636027449 0.000539068525734774 yes 25 0.000739235705462281 171 16725076
SGTC_2119 5528445 120.635 µM 3.17793227054387 0.000540917972929368 yes 26 0.000741646981356205 47 791935
SGTC_3003 9075612 71.4286 µM 3.13914602055117 0.000622170944542495 yes 27 0.000847204956747821 50 6501993
SGTC_2055 5235184 200 µM 3.12188819035386 0.000661828749853171 yes 28 0.000898475851627766 73 2836034
SGTC_814 3342-0569 96 µM 3.10187786763403 0.000710725655778637 yes 29 0.00096148638454261 66 4346283
SGTC_2436 5633522 8.09 µM 3.08473481479594 0.000755242370882978 yes 30 0.00101866858185841 45 5724242
SGTC_1847 st056231 15 µM 3.07632517491952 0.000778006829896897 yes 31 0.00104784579083679 86 5393180
SGTC_2499 avocadenofuran 51.48 µM 3.03905928601107 0.00088668781560793 yes 32 0.00118659073524267 86 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_377 3970-0964 33.1 µM 3.03120272114556 0.000911312184510236 yes 33 0.00121790824106275 102 16481235
SGTC_2065 5221596 34.26 µM 3.02541640273811 0.0009298480512336 yes 34 0.00124145515993701 53 788581
SGTC_1328 1441-0025 69.2 µM 3.00955903963321 0.000982434977049307 yes 35 0.00130813612509912 37 4562601
SGTC_337 1315-0038 354 µM 2.99657175588384 0.00102752277564872 no 36 0.00136516985874614 60 1626437
SGTC_1045 1348-1485 165 µM 2.95720579106574 0.0011760380866612 no 37 0.00155220425066606 101 6810614
SGTC_392 N-ethylmaleimide 8.33 µM 2.95357587416319 0.00119067811845769 no 38 0.00157057690279099 47 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1122 capsaicin 818.572 nM 2.94962687418504 0.00120679441089586 no 39 0.00159078955585392 74 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_382 3229-0966 23.2 µM 2.94777189588201 0.00121443348700079 no 40 0.00160036571719759 60 5722370
SGTC_1841 st054148 70 µM 2.94728706236875 0.00121643738553661 no 41 0.0016028772722078 57 675442
SGTC_6 0844-0013 19.835 µM 2.91598553404427 0.00135240131627349 no 42 0.00177283470036403 226 1584900
SGTC_296 1222-0039 74.9 µM 2.90408328967804 0.00140764609462577 no 43 0.00184165079651049 55 5984176
SGTC_1348 1493-0373 93.8 µM 2.89572991601461 0.00144764103878733 no 44 0.00189138906489577 57 3010129
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.8432817815765 0.00172337084359113 no 45 0.00223257871811926 104 688664
SGTC_409 arachidonic acid 100 µM 2.83077945605825 0.00179579043632942 no 46 0.00232173635061334 58 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3176 9106582 49.47 µM 2.81620429350963 0.00188370467252463 no 47 0.00242973774726287 13 17018027
SGTC_1143 3454-2408 5.08 µM 2.81187088438193 0.00191058716914535 no 48 0.0024627135137535 26 X1143
SGTC_1450 4112-4260 37.6 µM 2.80090166905626 0.00198020020592514 no 49 0.00254800221550281 84 1633175
SGTC_2033 5192550 145 µM 2.77588602651391 0.00214764782002682 no 50 0.00275257515742809 63 182073
SGTC_1866 st057638 64 µM 2.7749889671362 0.0021538842001814 no 51 0.00276017902567685 67 688802
SGTC_2521 angolensin 13.4 µM 2.76372902181452 0.00223357230232631 no 52 0.00285724871085528 60 821428 A flavenoid.
SGTC_3080 9117754 49.47 µM 2.73507431991144 0.00244855425252769 no 53 0.0031183096599931 79 9550191
SGTC_958 1222-0007 33 µM 2.72308592460464 0.00254392311178548 no 54 0.00323376171376614 104 7312461
SGTC_2088 5278280 127.392 µM 2.71287387904045 0.00262779539731311 no 55 0.00333512440513054 111 791502
SGTC_960 1222-0186 7.7 µM 2.71035400615394 0.0026488718749373 no 56 0.00336057150539857 102 3126296
SGTC_1439 4092-1168 46 µM 2.6957948130753 0.00277366387361979 no 57 0.00351104537330151 58 2886240
SGTC_2419 paclitaxel 166.5 µM 2.61695139166588 0.00354626120997714 no 58 0.00443594871237204 161 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1674 st016616 23.6 µM 2.61249241652057 0.00359524012603113 no 59 0.00449423432113241 116 625830
SGTC_2850 9015429 58.44 µM 2.61097119401089 0.00361208814425696 no 60 0.00451427491861007 93 6457570
SGTC_1366 1683-0113 21.9 µM 2.59240055390695 0.00382355130162195 no 61 0.00476543657684327 76 708623
SGTC_1325 1431-0015 227 µM 2.59002803593321 0.0038513515528953 no 62 0.00479840578870997 92 1103340
SGTC_3288 9119690 36.221 µM 2.58977033618321 0.00385438205966032 no 63 0.00480199907697003 78 17595618 YKL019W RAM2
SGTC_1724 st037281 8.293 µM 2.57678898243817 0.00400983339621418 no 64 0.00498614042927369 160 574124 YDL195W SEC31
SGTC_996 3970-0799 1.8 µM 2.57037289469527 0.0040887195592793 no 65 0.00507945492975751 218 6615648 YGL040C HEM2
SGTC_2561 acetosyringone 100 µM 2.56717779995368 0.00412851913338609 no 66 0.00512650124161133 135 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1302 1159-0335 255 µM 2.56237162233103 0.00418904015348755 no 67 0.00519800067679922 78 649284
SGTC_3062 9077494 49.47 µM 2.56104118942881 0.00420593306771646 no 68 0.0052179491314798 119 16459633
SGTC_1441 4106-0040 13 µM 2.53301577925199 0.00457622941498027 no 69 0.00565429310641022 86 2904180
SGTC_680 0417-1641 114 µM 2.51430146374273 0.00483943855349795 no 70 0.00596342172652037 96 2835990
SGTC_2297 7971671 152.32 µM 2.50220823792726 0.00501662255101439 no 71 0.00617106534470196 107 909016
SGTC_583 1488-1091 88.9 µM 2.49668041983401 0.00509952038637441 no 72 0.00626809393005204 121 4303273
SGTC_1341 1486-1360 280 µM 2.48752196563352 0.00523955143520968 no 73 0.00643182547860964 119 3976547
SGTC_1516 st013856 110 µM 2.46685773372335 0.0055681405416817 no 74 0.00681522501964753 80 5281404 A mutagen and neurotoxin.
SGTC_1824 st053723 68.6 µM 2.46558341501073 0.00558899049744797 no 75 0.00683951604176016 134 675225
SGTC_2234 tolnaftate 200 µM 2.46303885125139 0.00563083133365336 no 76 0.00688824934583896 33 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3302 9125395 16.351 µM 2.45826147178238 0.00571013879833304 no 77 0.00698057426747814 104 17599668
SGTC_1936 st074407 74.3 µM 2.45204889179363 0.00581475376760542 no 78 0.00710226801405596 175 809813
SGTC_2849 9019321 12.99 µM 2.44845497881884 0.00587604576546415 no 79 0.0071735179371287 142 16489627
SGTC_1240 0356-0016 42.1 µM 2.44768937370572 0.00588917649544364 no 80 0.00718877739375238 139 4305613
SGTC_3056 9094900 49.47 µM 2.43192168779475 0.00616545390509705 no 81 0.00750947709854408 136 25236784
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.42753980181488 0.00624424343376387 no 82 0.00760080936563179 176 91467 include heat shock
SGTC_2947 9072639 7.68 µM 2.40422980036242 0.00667854480011657 no 83 0.00810329098805066 191 16488146
SGTC_2049 5262831 67.185 µM 2.40362337370912 0.00669019127362245 no 84 0.00811674414517302 152 763417
SGTC_2900 5328528 85.29 µM 2.40268167792946 0.0067083121992289 no 85 0.0081376739221963 154 795359
SGTC_2121 5257820 149.641 µM 2.38163148676092 0.00712485903332896 no 86 0.00861806812190192 120 791256
SGTC_302 1094-0063 18.9 µM 2.36797766065885 0.00740709443105367 no 87 0.00894280790250543 94 5440289
SGTC_160 3453-0671 289.699 µM 2.36448182419844 0.00748092179949822 no 88 0.00902765664474977 169 5322268
SGTC_121 0557-0495 61.343 µM 2.3503118058512 0.00778685418771943 no 89 0.009378845226587 245 3104427
SGTC_754 3474-0146 171 µM 2.34995395418892 0.00779472072687307 no 90 0.00938786679105539 149 24762078
SGTC_623 k072-0108 16.9 µM 2.33980450866749 0.00802076359687854 no 91 0.00964691801659737 147 5382803
SGTC_2736 butenafine 14.65 µM 2.33969522078481 0.00802322863338831 no 92 0.00964974110730485 171 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3006 9075424 71.4286 µM 2.33858300775924 0.00804835299174759 no 93 0.00967851253571239 131 7465181
SGTC_649 1123-0311 367 µM 2.33662787722495 0.00809268612274089 no 94 0.00972927081864566 217 693629 YIL048W NEO1
SGTC_2712 st079126 47.7 µM 2.33475376772462 0.00813538339965176 no 95 0.00977814382379763 132 3152970
SGTC_2022 5136654 200 µM 2.33117776354795 0.00821740393937963 no 96 0.00987199408126679 126 1713771
SGTC_933 2914-0560 114 µM 2.3133294612899 0.00863773240550789 no 97 0.0103522660400438 169 463887
SGTC_1486 3970-0793 4.53 µM 2.31091811699329 0.0086959417407244 no 98 0.0104186890798904 95 2844330
SGTC_410 α-linolenic acid 100 µM 2.30360506511237 0.00887458593246302 no 99 0.0106224116332876 156 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2385 9074692 200 µM 2.30136577146917 0.00892992704995481 no 100 0.0106854824753647 170 17046906
SGTC_2729 fluphenazine 10.66 µM 2.29773768317706 0.0090202322404342 no 101 0.0107883617173465 148 3372 An atypical antipsychotic.
SGTC_2831 7999036 19.48 µM 2.29454353042143 0.00910039758399755 no 102 0.0108796488272181 205 2988270
SGTC_2299 7976368 114.88 µM 2.29176472707104 0.00917064540681493 no 103 0.0109596115509203 140 2979718
SGTC_1340 1486-1359 257 µM 2.29156916952117 0.00917560690938177 no 104 0.0109652581164045 147 4309068
SGTC_1146 3579-1023 7 µM 2.29149621404186 0.00917745846903757 no 105 0.0109673652948261 155 X1146
SGTC_2312 7706453 155.7 µM 2.27367705585513 0.00963960753547921 no 106 0.0114927053377125 161 976098
SGTC_2566 crystal violet carbinol 226 nM 2.26421915586298 0.00989306860484774 no 107 0.0117803194871963 168 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_669 0108-0021 26.2 µM 2.25318052963259 0.0101962338954448 no 108 0.0121238842659106 276 17201
SGTC_342 k048-0088 23.3 µM 2.23702602754643 0.0106545007820643 no 109 0.0126423194906375 154 6820570
SGTC_1641 st009299 47.1 µM 2.22920680731289 0.0108826859363451 no 110 0.0129000739104595 92 4046054
SGTC_1845 st056753 3.01 µM 2.22350154654278 0.0110518529923854 no 111 0.013090999609619 199 5375839
SGTC_2704 st078022 71.1 µM 2.21989139242939 0.0111600755400498 no 112 0.0132130704755093 151 54697681
SGTC_2023 5144124 124 µM 2.21944842043653 0.0111734178892709 no 113 0.0132281163043397 154 2830192
SGTC_2208 7283366 200 µM 2.21804123498912 0.011215894469035 no 114 0.0132760105007744 135 898663
SGTC_2202 7226349 200 µM 2.21768968990859 0.0112265279190179 no 115 0.0132879988566752 113 844334
SGTC_1020 4335-0961 93.3 µM 2.21012476928654 0.0114574826381562 no 116 0.0135482521319045 153 669075
SGTC_393 acivicin 6.25 µM 2.20994462209261 0.0114630324217545 no 117 0.0135545029293993 135 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1719 st032227 49.2 µM 2.19184723195736 0.0120325918120387 no 118 0.0141952696730296 175 3125804
SGTC_1071 trifluoperazine 6.31 µM 2.18449103827477 0.0122710272786421 no 119 0.014463092546251 184 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_641 4092-0595 30 µM 2.17869738366616 0.0124616878013074 no 120 0.0146770781281809 178 786260
SGTC_2959 9079155 11 µM 2.16937746948538 0.0127737751927486 no 121 0.0150270190295202 164 16189457
SGTC_1663 st014140 55.4 µM 2.15148318493916 0.0133919749567611 no 122 0.0157190408161224 195 4207120
SGTC_1737 st035557 69.7 µM 2.13688919652116 0.0139151229089931 no 123 0.0163035024575457 153 5716916
SGTC_3048 9093155 49.47 µM 2.13346219034631 0.0140404942267846 no 124 0.0164434150532374 123 25236002
SGTC_1419 3993-2473 62.6 µM 2.12590650210259 0.0143203501419828 no 125 0.0167555226961945 180 704026
SGTC_2429 5902844 64.44 µM 2.12095027611575 0.014506522198266 no 126 0.0169629935438819 229 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2908 7930301 100 µM 2.11568281014373 0.0147066653811706 no 127 0.0171858967659724 232 2223178
SGTC_1116 jasmonic acid 1.58368 µM 2.10820946787884 0.01499469663099 no 128 0.0175064373435211 200 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_853 0419-0306 21 µM 2.10730826817644 0.0150297553701481 no 129 0.0175454335643163 151 762713
SGTC_306 1672-3436 11.6 µM 2.10708182410071 0.0150385756321197 no 130 0.0175552437774654 182 6797378
SGTC_2162 5663267 200 µM 2.10456413433509 0.0151369426753981 no 131 0.0176646331961915 155 6456493
SGTC_21 0849-0113 22.993 µM 2.10446713624691 0.0151407434594679 no 132 0.0176688592122005 226 1560156
SGTC_1903 st060211 78.3 µM 2.09481359302888 0.0155231334778553 no 133 0.0180937831449267 226 688960
SGTC_2978 9011784 42.97 µM 2.09397036544724 0.0155569251107048 no 134 0.0181313101036396 246 2994934
SGTC_1921 5740136 50 µM 2.09135966121771 0.0156619474642669 no 135 0.0182479176837259 258 1774243
SGTC_1108 betulinic acid 729.144 nM 2.07759998953133 0.016225572769414 no 136 0.0188731085783404 194 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_891 0929-0073 133 µM 2.06382155256642 0.0168072889536906 no 137 0.0195173194001615 185 5603632
SGTC_934 2950-0684 338 µM 2.06156363063434 0.0169042981900656 no 138 0.0196246498041686 197 1121253
SGTC_2951 9072950 58.06 µM 2.05533199820725 0.0171745213767421 no 139 0.0199234743526189 229 16488155
SGTC_1412 3909-8563 178 µM 2.04545032988057 0.0176105867187711 no 140 0.0204052406690005 222 23767530
SGTC_516 3992-2719 87.3 µM 2.04171309407763 0.0177779513895443 no 141 0.0205899995696651 194 5350887 YDR037W KRS1
SGTC_2305 7443522 69.23 µM 2.04161093255117 0.0177825454793379 no 142 0.0205950699951357 200 5415886
SGTC_2846 9008642 19.48 µM 2.0407953539424 0.0178192574687435 no 143 0.0206355862897485 189 2992898
SGTC_746 1095-0025 46.6 µM 2.03575787236073 0.0180474476485635 no 144 0.0208873373080278 206 6749286
SGTC_857 0438-0306 1.35 µM 2.03490838423717 0.0180861726009721 no 145 0.0209300461106855 185 4686136
SGTC_396 dithiazanine 1.25 µM 2.02315880553134 0.0186290983607982 no 146 0.0215283886484347 148 10578 An antihelmenthic.
SGTC_1424 4048-1941 275 µM 2.0159081608253 0.0189710116236733 no 147 0.0219047900511104 233 X1424
SGTC_2917 7979103 53.79 µM 2.01499095829183 0.0190146414043452 no 148 0.0219527982316225 260 2980565
SGTC_454 lyso-paf C-16 6.67 µM 1.99574886400369 0.0199498193505001 no 149 0.02298063269809 227 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_140 0062-0056 502.533 µM 1.99525119710726 0.0199745149845693 no 150 0.0230077448566371 245 3758964
SGTC_260 nsc-65238 3.989 µM 1.97604733152929 0.0209474704385235 no 151 0.024074708369339 194 3246252
SGTC_1179 1021-1431 9.29 µM 1.97400883724472 0.0210530661737227 no 152 0.0241903690480065 297 2840958
SGTC_1161 k007-0610 110 µM 1.96849652284697 0.0213408668686174 no 153 0.0245054679001744 363 5843850
SGTC_2734 clemastine 41.6 µM 1.96679672045782 0.0214302827388446 no 154 0.0246033254140147 88 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_29 0299-0004 12.984 µM 1.96218927682443 0.0216742453904583 no 155 0.0248702259543239 158 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2428 5615643 7.78 µM 1.96085131182523 0.0217455283201188 no 156 0.0249481851710896 230 2253075
SGTC_2168 5727979 200 µM 1.95779316535232 0.0219092014992708 no 157 0.0251271438686558 189 695210
SGTC_2054 5233173 129 µM 1.94718181892248 0.0224852142481727 no 158 0.025756470294904 299 6889
SGTC_1660 st012960 28.1 µM 1.9465949146187 0.0225174422568573 no 159 0.0257916593863029 258 24207266
SGTC_628 1636-0253 16 µM 1.90117806391488 0.0251322140011019 no 160 0.0286393466564126 284 4456143
SGTC_1288 0973-0013 65.5 µM 1.89801106386324 0.0253236701048886 no 161 0.0288473122948359 233 4315430
SGTC_1906 st060206 94.7 µM 1.89682721058815 0.0253955511797318 no 162 0.02892537339162 255 5133468
SGTC_3028 9087778 49.47 µM 1.88868117036858 0.0258948093143904 no 163 0.0294672815946279 222 17217395
SGTC_703 3875-0075 71.8 µM 1.88733866693773 0.0259778723514824 no 164 0.0295573944032761 197 2850814
SGTC_776 4476-4378 112 µM 1.8858310948323 0.026071414040412 no 165 0.0296588596366376 217 2892008
SGTC_764 1951-2361 146 µM 1.88296524825009 0.026250010635375 no 166 0.0298525388366146 264 5438930
SGTC_1344 1488-0097 29.1 µM 1.87916953528284 0.0264881289682626 no 167 0.0301106739819198 244 747966
SGTC_338 4055-0136 114 µM 1.87911414563534 0.0264916170714229 no 168 0.0301144545230176 266 2900563
SGTC_1749 st037932 54.2 µM 1.87053166484944 0.0270367457508852 no 169 0.030705012024812 271 594497
SGTC_1417 3966-0327 90.4 µM 1.86715973544626 0.0272534652139042 no 170 0.0309396422828115 278 651118
SGTC_1491 4138-0063 26.5 µM 1.86446811386128 0.0274274985034837 no 171 0.0311279976681203 202 23883227
SGTC_1897 st060201 15 µM 1.86428988288265 0.0274390550966286 no 172 0.0311405034024705 235 611878
SGTC_2264 7948757 110.76 µM 1.8584346069865 0.0278209780909583 no 173 0.031553660821634 267 2971411
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.85777566974403 0.0278642346251754 no 174 0.0316004387959126 147 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1738 st035555 74 µM 1.85641287127646 0.0279538745484573 no 175 0.0316973657508387 300 5331140
SGTC_2701 st077767 14.721 µM 1.85629657258605 0.0279615353636529 no 176 0.0317056486814171 319 5721188
SGTC_1233 0325-0408 14.2 µM 1.85341362305801 0.0281520003631373 no 177 0.0319115480990712 265 12874
SGTC_2940 9060638 45.86 µM 1.84321389475183 0.0288345467795936 no 178 0.0326488934903134 292 4027022
SGTC_476 mead acid 10 µM 1.83932087300344 0.0290986623711742 no 179 0.0329340023641763 169 5312531 An omega 9 fatty acid.
SGTC_998 3996-0085 177 µM 1.8387051652928 0.029140617557561 no 180 0.0329792816389525 298 715391
SGTC_1806 st050005 60.3 µM 1.83778710258181 0.0292032689605071 no 181 0.033046891431098 275 5194765
SGTC_359 0081-0058 15.9 µM 1.83637049100402 0.029300162359135 no 182 0.0331514403932266 289 3494159
SGTC_2785 7756463 72.73 µM 1.83510176219018 0.0293871673644191 no 183 0.0332453064470474 269 2201551
SGTC_2801 7907800 81.82 µM 1.83198777919765 0.0296016232167028 no 184 0.0334766206792684 285 6620925
SGTC_1136 pergolide 1.05886 µM 1.82901579074542 0.0298075099109066 no 185 0.0336986213625807 384 47811 A dopamine receptor agonist.
SGTC_768 0384-0033 77.3 µM 1.8188988104868 0.0305172951498871 no 186 0.0344634346823582 355 3965305 YMR134W ERG29
SGTC_688 0527-0193 473 µM 1.81881275581773 0.0305233920883093 no 187 0.0344700008218845 229 4007154
SGTC_2865 9030313 51.95 µM 1.81071770167445 0.0311014514580764 no 188 0.0350922806434387 231 42562754
SGTC_2227 7312221 64.1025 µM 1.80911048871446 0.0312172918039561 no 189 0.035216919956774 182 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1243 0416-0003 5.65 µM 1.80476493020484 0.0315322871710046 no 190 0.0355557372066962 315 2141977
SGTC_2824 7998404 51.95 µM 1.80166798418407 0.0317583743432621 no 191 0.0357988290483536 262 837851
SGTC_17 0960-0276 49.807 µM 1.7972210586072 0.0320853551925363 no 192 0.036150266332843 328 6821114
SGTC_1772 st048439 82.2 µM 1.79609872143419 0.032168318084859 no 193 0.0362394088811822 327 2927068 YDL195W SEC31
SGTC_2823 7987624 58.44 µM 1.78777738938707 0.0327889679383747 no 194 0.0369059650908444 337 2239440
SGTC_2822 7994718 71.43 µM 1.78736447859442 0.0328200203762847 no 195 0.0369392994320016 235 1018011
SGTC_2993 9054257 71.4286 µM 1.7818937352387 0.0332337339649118 no 196 0.037383281178391 350 6470217 YGL055W OLE1
SGTC_3054 9094397 49.47 µM 1.78030127137316 0.0333549647356576 no 197 0.037513334591349 326 2598354
SGTC_2319 6033012 152.6 µM 1.77596518530922 0.0336869082157448 no 198 0.0378693278032833 244 847246
SGTC_3174 9107204 49.47 µM 1.77313122018152 0.0339053241786903 no 199 0.0381034828852315 297 3938802
SGTC_1222 0366-0074 1.18 µM 1.76808415083668 0.0342971898291492 no 200 0.0385234183192533 292 286520
SGTC_2661 dactinomycin 12.96 µM 1.76786923906496 0.0343139583389989 no 201 0.038541383190502 312 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_832 4083-0019 164 µM 1.76630028620099 0.0344365802762576 no 202 0.038672741807266 487 1990758
SGTC_629 3448-6466 76.7 µM 1.76625005973217 0.034440511679336 no 203 0.0386769529735184 320 573744
SGTC_276 colchicine 750 µM 1.7613286972429 0.0348275161720913 no 204 0.0390913928076275 323 2833 A microtubule depolymerizer.
SGTC_1722 st034304 3.6505 µM 1.75551089420676 0.0352896122804352 no 205 0.0395859794325065 325 4036148 YLR033W RSC58
SGTC_526 4469-0568 170 µM 1.75532767243704 0.0353042465006667 no 206 0.0396016378763637 318 2901964
SGTC_942 3253-1115 227 µM 1.75263469581574 0.0355199137227584 no 207 0.0398323658719882 306 46497897
SGTC_162 k030-0015 37.8 µM 1.75158999722356 0.0356038687469834 no 208 0.0399221668995272 279 1809920 YMR134W ERG29
SGTC_2025 5147754 141 µM 1.74845865333635 0.0358564875982627 no 209 0.0401923195815813 268 315777 YLR208W SEC13
SGTC_2070 5230947 200 µM 1.74789520675194 0.0359020987589745 no 210 0.0402410875026272 292 2835538
SGTC_1225 1216-0074 20.6 µM 1.74271561681741 0.0363236186986983 no 211 0.0406916511878449 297 4241466
SGTC_2809 7964133 12.99 µM 1.73406694532168 0.0370364791001162 no 212 0.0414531028166688 360 1253665
SGTC_2441 5730946 39.09 µM 1.73336306590204 0.037094995580383 no 213 0.0415155789558299 319 1774275
SGTC_2872 9044037 25.97 µM 1.73069545059626 0.0373174519482671 no 214 0.0417530485504141 222 6465195
SGTC_3197 9113331 49.47 µM 1.72999005525556 0.0373764577467902 no 215 0.041816026011348 339 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_627 1391-0720 175 µM 1.72797200674978 0.0375456870035288 no 216 0.0419966216224215 305 997839
SGTC_450 aminopyrene 156 nM 1.72324749178093 0.0379443224632111 no 217 0.0424218893787118 343 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_362 0310-0100 9.03 µM 1.72210271742962 0.038041431858559 no 218 0.0425254564712427 335 790235
SGTC_3144 9087057 49.47 µM 1.72160190620722 0.0380839785812888 no 219 0.0425708288273799 313 17249618
SGTC_1199 1638-0010 4.46 µM 1.71582747670754 0.0385773581761483 no 220 0.043096811793695 353 3111136
SGTC_95 0471-0001 561.058 µM 1.70829559723459 0.0392287126750545 no 221 0.0437907539202795 336 4015405
SGTC_2653 dihydrofissinolide 100 µM 1.70515033557845 0.0395033501283634 no 222 0.0440831949318319 249 6857746
SGTC_2882 9058044 58.44 µM 1.70100393870414 0.0398677923156247 no 223 0.0444711237923876 295 18076804
SGTC_864 0469-0573 172 µM 1.69657133047012 0.0402604082295763 no 224 0.0448888669352619 314 689425
SGTC_1512 0259-0544 12.2 µM 1.69465785543591 0.0404308609268162 no 225 0.0450701724593352 354 18476
SGTC_1 0258-0098 57.368 µM 1.6886522124716 0.0409696534660829 no 226 0.0456430492610766 275 6790032 YDR047W HEM12
SGTC_2618 avocadyne 43.43 µM 1.68541245836798 0.0412627154957472 no 227 0.0459545108235716 294 3015189
SGTC_1688 st021091 57.6 µM 1.68321295638813 0.0414626450731591 no 228 0.0461669367677998 277 3656366
SGTC_3316 9136639 10.545 µM 1.68066453283757 0.0416952716896335 no 229 0.0464140466791571 307 4903665
SGTC_1297 1068-0111 14.1 µM 1.67504290312275 0.0422121670244428 no 230 0.0469629071145906 306 767057
SGTC_1477 0139-0234 16 µM 1.67192874654466 0.042500730530559 no 231 0.0472691867189609 307 620880
SGTC_1046 2001-0062 216 µM 1.66971214567037 0.0427070951295158 no 232 0.0474881647731879 339 739778
SGTC_1605 st000082 49.1 µM 1.66878332767603 0.0427938081724809 no 233 0.0475801640146249 305 1114022
SGTC_3310 9130229 44.1445 µM 1.66742353706054 0.0429210127813573 no 234 0.0477151084469454 330 7761258
SGTC_1763 st044482 94.5 µM 1.66658148779997 0.0429999372040427 no 235 0.0477988262242363 349 88505
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.66304324009857 0.0433328559746834 no 236 0.0481518901634015 387 23665772 A membrane-active detergent.
SGTC_200 k038-0079 37.545 µM 1.66292114728115 0.0433443809046083 no 237 0.0481641103366814 333 3436683
SGTC_510 ag-490 170 µM 1.6618494184912 0.0434456527996243 no 238 0.0482714853443776 302 5328779
SGTC_354 2783-3500 4.88 µM 1.66092817365566 0.0435328574568922 no 239 0.0483639365502027 373 6740761
SGTC_2586 curcumin 80 µM 1.65905944398326 0.0437101845830173 no 240 0.048551907261368 425 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_663 1486-0733 13.9 µM 1.65358249359299 0.0442332614982672 no 241 0.0491061860545246 409 722445 YPR165W RHO1
SGTC_607 4491-0986 66.8 µM 1.64936078531308 0.0446398902799699 no 242 0.0495368717556622 350 698981 YDR232W HEM1
SGTC_612 0302-0167 22.4 µM 1.64449940109553 0.0451118556004806 no 243 0.0500365439548542 422 235821
SGTC_2116 5511452 16.8835 µM 1.64396263207805 0.0451642128373301 no 244 0.050091960684992 354 870744
SGTC_2425 5628681 7.85 µM 1.64222084691984 0.0453344459465212 no 245 0.0502721219323845 414 5714958
SGTC_786 4544-0069 423 µM 1.64194628400939 0.0453613273420779 no 246 0.0503005683624242 363 748821 YLR208W SEC13
SGTC_2642 cholecalciferol 100 µM 1.64003975089906 0.0455483424288078 no 247 0.0504984510617987 301 9821465 A vitamin D precursor, similar to steriods.
SGTC_1109 tnp00067 928.257 nM 1.63969664073874 0.0455820644221998 no 248 0.0505341288811131 319 676295
SGTC_1687 st020778 55.3625 µM 1.63214361478107 0.0463294981885016 no 249 0.051324617824776 532 4259299
SGTC_2200 6600604 21.907 µM 1.62997518415464 0.0465458907326936 no 250 0.0515533709533882 398 2904777
SGTC_2478 5763493 32.33 µM 1.62939787941024 0.0466036377822043 no 251 0.0516144087124785 339 1365576 YLR208W SEC13
SGTC_2989 9073649 71.4286 µM 1.62924851829113 0.0466185875400008 no 252 0.0516302098418563 463 21367202
SGTC_1629 st005085 44.9 µM 1.62001292620137 0.0475504909752224 no 253 0.0526147501162331 367 24207091
SGTC_120 rhodamine 6G 52.259 µM 1.61760566160559 0.0477958282611124 no 254 0.0528738040950562 455 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2028 5153890 36.43 µM 1.61717719791583 0.0478396013664189 no 255 0.0529200184266229 359 2830968 YPR165W RHO1
SGTC_470 aa-861 153 µM 1.61622747083429 0.0479367426868998 no 256 0.0530225707324525 413 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_265 mycophenolic acid 32.932 µM 1.60981414109399 0.0485968595995693 no 257 0.0537192185690073 388 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1701 st028638 40.4 µM 1.60829714604747 0.0487540602549318 no 258 0.0538850577121158 357 3490878
SGTC_2852 9023854 51.95 µM 1.60740109461708 0.0488471055616134 no 259 0.0539832050634312 384 19798528
SGTC_596 1155-0152 116 µM 1.60249549779826 0.0493590167177393 no 260 0.0545230411609427 440 280313
SGTC_378 3970-0959 8.33 µM 1.59932270438208 0.0496923802358756 no 261 0.0548744586098958 363 6615653
SGTC_3076 9116187 49.47 µM 1.59908288183665 0.0497176510969503 no 262 0.0549010938708996 335 27241210
SGTC_1193 1488-0126 41.5 µM 1.59856413185957 0.0497723485006788 no 263 0.0549587424274701 400 1384710
SGTC_1382 3002-2117 298 µM 1.59143460799633 0.0505289651816439 no 264 0.055755900484179 384 1497314
SGTC_2050 5263056 171 µM 1.58988241091367 0.0506948996936707 no 265 0.0559306565431072 443 763468 YGL055W OLE1
SGTC_2690 usnic acid 100 µM 1.58904203230353 0.0507849196003317 no 266 0.0560254517598232 437 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1157 4092-0394 27.6 µM 1.58864583523802 0.0508274036730319 no 267 0.0560701869606154 423 3659885
SGTC_2400 5203494 178.7 µM 1.58629976372823 0.0510795522852892 no 268 0.0563356629447044 340 6777674
SGTC_1828 st055811 49 µM 1.5799927825321 0.0517623446036321 no 269 0.0570542596771861 326 5877589
SGTC_136 0097-0015 404.482 µM 1.57801161208535 0.0519783166621225 no 270 0.0572814710689094 418 4861337
SGTC_3309 9129340 25.759 µM 1.57508628871118 0.0522985214348854 no 271 0.0576182642408391 388 17158987
SGTC_2839 9003951 25.97 µM 1.57213816787358 0.0526228043283929 no 272 0.057959255730871 342 2990634
SGTC_772 k072-0172 35.3 µM 1.56785662704302 0.0530965979404947 no 273 0.0584572979758081 346 5861980
SGTC_2383 9036125 200 µM 1.56758615171892 0.0531266418539006 no 274 0.0584888730230591 315 79580
SGTC_1769 st044406 64.4 µM 1.56621162867981 0.0532795297546214 no 275 0.0586495406150374 414 670903
SGTC_2614 arthonioic acid 13.39 µM 1.56354319567555 0.0535773345409824 no 276 0.0589624419535394 355 6710684
SGTC_2894 9048625 32.47 µM 1.55747214871088 0.0542597938614665 no 277 0.0596792140438306 368 4092861
SGTC_1550 gossypolone 36.6 µM 1.5526858685179 0.0548026637772989 no 278 0.0602491000035189 407 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_882 0843-0131 351 µM 1.54890016407386 0.0552350797756715 no 279 0.0607028607546708 409 5425421
SGTC_1118 chelidonine 707.474 nM 1.54486571867216 0.0556988694577261 no 280 0.0611893735093991 409 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1909 st060837 51.5 µM 1.53499584789476 0.0568464427759084 no 281 0.0623924239743466 433 678937
SGTC_1385 3091-4834 14.1 µM 1.53288275402329 0.0570945363747589 no 282 0.0626523729258357 378 4072814
SGTC_2190 6049624 200 µM 1.53271996767608 0.0571136840584216 no 283 0.0626724335731336 333 2265554
SGTC_910 3454-3003 490 µM 1.53169715554716 0.057234107636803 no 284 0.06279859233004 438 820824
SGTC_2179 6298986 200 µM 1.52972253117802 0.0574671606358988 no 285 0.0630427120691839 365 738374
SGTC_128 0906-2981 13.371 µM 1.52764665643273 0.0577129678625114 no 286 0.0633001455400084 358 6740226
SGTC_447 ml7 120 µM 1.51569023164194 0.0591448752314501 no 287 0.0647988494114198 410 4216 Selective myosin light chain kinase inhibitor.
SGTC_1331 1472-0049 76.2 µM 1.51450471640738 0.0592883582985278 no 288 0.0649489392623451 409 24051409
SGTC_2210 7115885 190.385 µM 1.51383773251503 0.0593692033399702 no 289 0.0650335000062158 414 2927039
SGTC_282 k297-0036 65.7 µM 1.51133027730327 0.0596739051144349 no 290 0.0653521617819675 353 5061378
SGTC_2187 6125751 200 µM 1.50972102283614 0.0598701037050322 no 291 0.0655573123160316 424 874498
SGTC_1234 0326-0494 15.5 µM 1.50839876776336 0.0600316894768245 no 292 0.0657262491062292 385 1547813
SGTC_2317 5986382 200 µM 1.50441616844113 0.0605204456523831 no 293 0.0662371218659974 392 877883
SGTC_1777 st045864 34.765 µM 1.50348068822626 0.0606357008168306 no 294 0.0663575666075595 420 4691462
SGTC_584 0986-0246 15.4 µM 1.5027537227295 0.0607253845718776 no 295 0.0664512817558793 462 53315 YDR232W HEM1
SGTC_3278 9139605 49.47 µM 1.49711568731564 0.0614244601837862 no 296 0.067181579277808 408 7958859
SGTC_3116 9124943 49.47 µM 1.49367022696711 0.0618547571702877 no 297 0.0676309170280476 407 41905195 YPL160W CDC60
SGTC_62 0180-0423 3.232 µM 1.48964575294602 0.0623603411279696 no 298 0.0681587025629724 408 30102 YGL099W LSG1
SGTC_1962 st076595 64.5 µM 1.48953755209101 0.0623739784671511 no 299 0.0681729362159726 441 279619
SGTC_1264 0783-0040 158 µM 1.489424733098 0.0623882003402999 no 300 0.0681877798209753 396 2855798
SGTC_152 4469-0003 551.229 µM 1.48018434191991 0.0635616450451753 no 301 0.0694120289685007 410 697280
SGTC_2926 9010726 65.15 µM 1.4785864937278 0.0637662876304788 no 302 0.0696254323339027 448 2994293
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.47740372622506 0.0639180990588315 no 303 0.069783723961501 471 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_698 k064-0052 127 µM 1.47440926828994 0.0643037024888528 no 304 0.0701857152495757 353 5088751
SGTC_2616 abietic acid 100 µM 1.46880108171338 0.0650307426575686 no 305 0.0709433752953807 465 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_638 3970-0837 4.09 µM 1.46565712068171 0.0654411047406182 no 306 0.071370860672759 441 4118451 YLR208W SEC13
SGTC_2944 9067346 25.62 µM 1.46088154463083 0.0660682702533889 no 307 0.0720239760919101 458 6473075
SGTC_955 1216-0110 33 µM 1.45631368521776 0.0666725043263851 no 308 0.0726529620424664 518 3619719
SGTC_1160 4092-0570 10.5 µM 1.45541239463862 0.0667922301746997 no 309 0.0727775635396446 473 4994975
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.45477322667685 0.066877236885624 no 310 0.0728660262589798 434 803109
SGTC_318 1488-0629 67.2 µM 1.45377102540499 0.0670106940084896 no 311 0.0730048995492719 412 3662576
SGTC_2760 etidronate 98.04 µM 1.45053490677616 0.0674430351585813 no 312 0.0734547061745208 450 3305 A chelator and antioxidant.
SGTC_1984 st072354 53.1 µM 1.44931816787776 0.0676061463816698 no 313 0.0736243748517126 425 5762938
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.44892771098436 0.0676585540425498 no 314 0.0736788857364643 508 676296 Flavone; oxidizing agent.
SGTC_223 busulfan 5 mM 1.44840798102941 0.0677283615981004 no 315 0.0737514920277145 353 2478 A DNA alkylator.
SGTC_1152 3909-8331 15.9 µM 1.44779926613397 0.0678101918969577 no 316 0.0738365990404092 425 16001939
SGTC_1484 3473-2379 286 µM 1.44672615384908 0.0679546376577065 no 317 0.0739868181901802 542 671917
SGTC_868 0527-0199 213 µM 1.44571389158666 0.0680911103825739 no 318 0.0741287331927895 471 2849450
SGTC_2774 tamoxifen 10.92 µM 1.43670126691604 0.0693155329029518 no 319 0.0754014474171393 441 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2482 5981709 142.65 µM 1.43584301244074 0.0694330111043963 no 320 0.0755235087096956 498 877755
SGTC_912 3474-0017 2.18 µM 1.43199952072573 0.0699609915363486 no 321 0.0760719792401138 471 3360550
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.43025113264127 0.0702021874901495 no 322 0.0763224773306307 440 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_170 4197-0004 226 µM 1.42694748266227 0.0706596823137865 no 323 0.0767975164416841 401 218692
SGTC_554 4483-2211 187 µM 1.42645202501268 0.0707284912267123 no 324 0.0768689528217025 461 747107
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.42558854588827 0.0708485338257541 no 325 0.0769935722218175 395 17037758
SGTC_708 3448-5400 146 µM 1.42441687310321 0.0710116723422009 no 326 0.0771629163493637 498 3462195
SGTC_714 4296-0578 26.1 µM 1.42147470139542 0.0714225990467301 no 327 0.0775894015827066 342 1589775
SGTC_2206 7254556 146.969 µM 1.42070343147154 0.0715306219690068 no 328 0.0777014972672457 396 4398905
SGTC_1352 1496-0991 99 µM 1.41586363270223 0.0722113407408023 no 329 0.0784077172558833 439 3000039
SGTC_537 1334-0398 209 µM 1.41467313412833 0.0723795430553473 no 330 0.0785821774663699 491 5846986
SGTC_3250 9135583 49.47 µM 1.40891962309589 0.0731966749437152 no 331 0.0794294682036519 440 7699353
SGTC_2449 5812982 45.77 µM 1.40593436403377 0.0736234227214519 no 332 0.0798718079616045 434 776185
SGTC_1922 5578187 25 µM 1.39856379427457 0.0746852020405851 no 333 0.0809719149367177 469 1350412
SGTC_2323 6148992 148.28 µM 1.39834224277001 0.0747172979609008 no 334 0.0810051591639488 424 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2572 astragaloside iv 100 µM 1.38982819441534 0.0759587089007017 no 335 0.0822905271719482 483 45006101 An anti-inflammatory agent.
SGTC_1303 1160-0052 261 µM 1.38927977155955 0.0760392081890538 no 336 0.0823738462846188 480 3562476
SGTC_2624 nerol 100 µM 1.38424519957004 0.0767812365676004 no 337 0.0831416937806214 459 637566 A natural product oil.
SGTC_760 0568-0725 82.9 µM 1.37496931798159 0.0781627752682593 no 338 0.084570478540844 501 3916171
SGTC_528 3492-0019 172 µM 1.37475938085539 0.0781942598321782 no 339 0.0846030274405739 738 2869262
SGTC_1132 3456-3614 2.5 µM 1.36738904589279 0.0793057060237067 no 340 0.0857516969951597 605 3125502
SGTC_3245 9134821 49.47 µM 1.3671003860525 0.0793494780308563 no 341 0.0857969211518807 521 17014901
SGTC_1776 st049249 45.9 µM 1.36065810592121 0.0803311419483698 no 342 0.0868108798681055 530 1822314
SGTC_357 1325-0123 420 µM 1.35763509818165 0.0807949342947856 no 343 0.0872897500786424 483 1098503
SGTC_3280 9140961 49.47 µM 1.35665859311834 0.0809451817205178 no 344 0.0874448574592827 473 4901226
SGTC_1766 st045414 44.774 µM 1.35522682600881 0.0811658580519545 no 345 0.0876726501408428 541 253960
SGTC_3070 9117005 49.47 µM 1.35498158464145 0.0812037022674197 no 346 0.0877117121617925 412 8779016
SGTC_2067 5224629 34.075 µM 1.35466422654007 0.0812526948758593 no 347 0.0877622801995167 506 2835000
SGTC_232 clozapine 119 µM 1.35449824676131 0.0812783271203645 no 348 0.0877887361808654 509 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1455 4262-0120 131 µM 1.34853686864902 0.0822029915560296 no 349 0.0887428851358993 529 1529587
SGTC_2877 9040724 71.43 µM 1.34486203530777 0.0827769263663039 no 350 0.0893348961732678 491 6463895
SGTC_2571 chrysanthemic acid 100 µM 1.34335853800424 0.0830126095480567 no 351 0.0895779528175912 485 2743 An insecticide.
SGTC_3093 9117344 49.47 µM 1.34123575870851 0.083346228178765 no 352 0.0899219599179401 501 24824913
SGTC_1032 k061-1018 98.7 µM 1.33866654170823 0.0837513564185735 no 353 0.0903396265592105 605 4005393
SGTC_2622 2-methoxyxanthone 59.94 µM 1.3350563245751 0.084323132577784 no 354 0.0909289562924691 526 71034 A hepatoprotective.
SGTC_5 0352-0601 109.883 µM 1.32910786015536 0.0852716159939917 no 355 0.0919061937231875 460 762456
SGTC_871 0574-0004 149 µM 1.3286894303786 0.0853386343661201 no 356 0.0919752267297424 572 9551173
SGTC_1316 1272-0050 65.9 µM 1.32689998048774 0.0856256892739875 no 357 0.0922708854173978 524 7340392
SGTC_298 1391-0729 10 µM 1.32417628238183 0.0860639985452788 no 358 0.0927222529182705 485 3237558
SGTC_2600 tangeritin 87.95 µM 1.32307046902498 0.0862424291361181 no 359 0.0929059721168909 505 68077 A bioactive flavone.
SGTC_879 0831-1030 162 µM 1.32165061306407 0.086471938181824 no 360 0.0931422606222864 603 1549252
SGTC_3115 9123671 49.47 µM 1.31792408418365 0.0870764751890785 no 361 0.0937645312292477 520 3286988
SGTC_654 1124-0271 80.9 µM 1.31363112242429 0.0877768081275632 no 362 0.0944851850167353 564 5403748
SGTC_51 1013-0126 23.419 µM 1.30687906590702 0.0888867940167412 no 363 0.095626893431635 513 1627850
SGTC_2728 chlorpromazine 9.18 µM 1.30323476010778 0.0894902152718859 no 364 0.0962473131761402 444 2726 A thorazine and dopamine antagonist.
SGTC_815 1582-0027 36.9 µM 1.30273677671072 0.0895729070038752 no 365 0.0963323209113557 544 3128206
SGTC_3340 9146634 11.102 µM 1.30137656230099 0.0897990644911894 no 366 0.0965647960655455 537 4907387
SGTC_3087 9117406 49.47 µM 1.30020750108664 0.0899937786268536 no 367 0.0967649302124369 525 42546093
SGTC_640 3381-0960 37.1 µM 1.29882544448251 0.0902243728895594 no 368 0.0970019202137524 570 1745025
SGTC_2836 9010338 19.48 µM 1.29479621552579 0.0908991488265179 no 369 0.0976952689325071 499 2994051
SGTC_2111 5486399 200 µM 1.29009019626271 0.0916919987770805 no 370 0.0985096716868 609 689674
SGTC_1714 st033236 13.627 µM 1.28970874547423 0.0917564877535547 no 371 0.0985759009889682 576 2916566
SGTC_1423 4048-0112 5.59 µM 1.28711163470103 0.0921964548687851 no 372 0.0990276903737497 550 X1423
SGTC_2991 9074669 71.4286 µM 1.28510722521503 0.0925370808660462 no 373 0.0993774085498694 625 17333109
SGTC_531 3788-1495 174 µM 1.28473844014601 0.0925998528596256 no 374 0.0994418503268116 547 2896655
SGTC_2569 tetrandrine 100 µM 1.28416630615428 0.0926972998027505 no 375 0.099541885888679 489 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2878 9043973 25.97 µM 1.28328177605177 0.0928481038781847 no 376 0.0996966874933884 518 6465167
SGTC_1898 st060199 18.6 µM 1.27917454736991 0.0935507250372787 no 377 0.100417798372008 523 688866
SGTC_1588 farnesol 29.9 µM 1.27316048995393 0.0945866190959306 no 378 0.10148054878605 561 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3236 9132701 49.47 µM 1.27006862833126 0.0951224578618835 no 379 0.102030092638212 557 24282524
SGTC_555 4296-0685 37 µM 1.26925301811068 0.0952641801054825 no 380 0.102175418530095 577 2908540 YHR072W ERG7
SGTC_956 1185-0240 191 µM 1.26702613134782 0.0956519205260254 no 381 0.102572973184713 557 1416193
SGTC_1875 nocodazole 6 µM 1.26477254420054 0.0960454908736469 no 382 0.102976438103221 565 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3141 9094609 49.47 µM 1.26292896330167 0.0963683414749816 no 383 0.103307355003575 538 25236309 YDL196W YDL196W
SGTC_482 fipronil 114 µM 1.26253296702973 0.0964377928559226 no 384 0.103378535689918 499 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_635 k038-0028 24.7 µM 1.26245836364798 0.0964508812059796 no 385 0.103391949699506 584 4035102
SGTC_2159 5658611 73.75 µM 1.2623393787376 0.0964717585121947 no 386 0.103413346313686 547 793844
SGTC_1113 artemisinin 1.17947 µM 1.26176941083425 0.096571812153666 no 387 0.103515886099388 589 2240 An anti-malaria and mitochondrial poison.
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.25836850386386 0.0971704009989186 no 388 0.104129258522015 549 5282362
SGTC_1803 st050068 52.4 µM 1.25551663846528 0.0976744490807562 no 389 0.104645635943285 782 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_179 1273-0063 6.77 µM 1.255321676141 0.0977089772420881 no 390 0.104681004711203 527 3108139
SGTC_2096 5468907 200 µM 1.2553174450416 0.0977097266762335 no 391 0.104681772385086 567 759785
SGTC_924 2046-0044 21.3 µM 1.24625929038205 0.0993238315307692 no 392 0.106334609120849 584 3623589
SGTC_573 3702-0553 84.7 µM 1.24454569796486 0.0996313629433003 no 393 0.10664939577551 575 1222756
SGTC_900 1112-0045 141 µM 1.24033681082001 0.100389666698114 no 394 0.107425421204033 460 56211 YIL048W NEO1
SGTC_2589 lobaric acid 100 µM 1.24001904339408 0.100447088521105 no 395 0.107484175282647 581 73157 A novel microtubule depolymerizer.
SGTC_1831 st055328 12 µM 1.23427485605824 0.101489221109026 no 396 0.108550251001419 615 1103068
SGTC_1431 4049-0260 9.09 µM 1.23387872927577 0.101561377135901 no 397 0.108624048366162 595 3854841
SGTC_3168 9103419 49.47 µM 1.23225847688753 0.101856901302944 no 398 0.108926272723024 483 16649256
SGTC_1983 st071813 46.9 µM 1.23166552263174 0.101965208840635 no 399 0.109037026946747 602 11838595
SGTC_2647 atorvastatin 60.16 µM 1.23007704584744 0.102255768972182 no 400 0.109334127397756 571 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2378 9074213 121.43 µM 1.22972585279654 0.102320089524311 no 401 0.109399891146578 616 657714
SGTC_2750 bromebric acid 70.15 µM 1.22784933758348 0.102664269547275 no 402 0.109751765369414 660 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_472 calcifediol 10 µM 1.22476040649763 0.103232655504084 no 403 0.110332753443804 523 5283731 A vitamin D metabolite.
SGTC_1448 4255-0083 152 µM 1.22299664120982 0.103558224297605 no 404 0.110665482456061 618 5399660
SGTC_1224 0823-0416 294 µM 1.22258536494829 0.10363424771562 no 405 0.110743171769328 608 3598164
SGTC_1683 st010134 710 nM 1.22105472051929 0.103917539422008 no 406 0.111032650992837 610 3818134
SGTC_553 k007-0256 45.7 µM 1.21916488778171 0.104268083952102 no 407 0.111390807899778 612 6287000
SGTC_2777 climbazole 1.536 µM 1.21730640634226 0.104613648213925 no 408 0.111743828881482 639 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1871 st057448 67.3 µM 1.21659365561297 0.104746396247753 no 409 0.111879428903654 638 691747
SGTC_2909 7941780 10.49 µM 1.21647043986006 0.104769357234017 no 410 0.11190288248634 624 1243215
SGTC_1421 4029-0249 71.4 µM 1.2162941989179 0.104802205683179 no 411 0.111936435293884 657 2894095
SGTC_364 0083-0097 67.7 µM 1.21549219836413 0.104951779746375 no 412 0.112089211270415 612 5207356
SGTC_371 0195-0006 7.36 µM 1.21190692781727 0.105622326683158 no 413 0.112774004968333 523 3928593
SGTC_1761 st044296 37 µM 1.20728159676057 0.106491963076521 no 414 0.113661857771587 610 1826700
SGTC_1479 0549-0158 134 µM 1.20637813707754 0.106662429742079 no 415 0.113835860991522 696 5440202
SGTC_636 0kpi-0074 126 µM 1.20457309298097 0.107003598880383 no 416 0.11418407459682 581 616434
SGTC_997 3996-0078 137 µM 1.2032251535123 0.107258884131921 no 417 0.114444601814257 640 735687
SGTC_2171 5739187 198.077 µM 1.19977786372404 0.107913760633646 no 418 0.115112811738172 538 2262761
SGTC_2730 imipramine 71.33 µM 1.19775244178406 0.108299867363962 no 419 0.115506703406901 723 3696 A tricyclic antidepressant.
SGTC_1293 1000-1278 195 µM 1.19545039428452 0.108739913283237 no 420 0.11595555320592 638 678847
SGTC_1185 1319-0113 81.3 µM 1.19390386883086 0.109036259174287 no 421 0.11625778698956 564 4672763
SGTC_2471 5466956 24.79 µM 1.19384783663948 0.109047006973359 no 422 0.116268747710545 601 724419
SGTC_838 0109-0203 71.4 µM 1.19136891881575 0.10952326214529 no 423 0.116754394498607 644 759422
SGTC_1617 st002906 78 µM 1.19125149113481 0.10954585960742 no 424 0.116777435473028 638 5150859
SGTC_2731 amoxapine 43.43 µM 1.19122147829854 0.109551635732815 no 425 0.116783324933845 507 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2199 6590217 200 µM 1.18950229856477 0.109882865898243 no 426 0.117121033523395 554 703109
SGTC_3025 9087895 49.47 µM 1.18939025916853 0.1099044771744 no 427 0.11714306607115 685 17173641
SGTC_2648 atorvastatin 78.68 µM 1.18903284693438 0.109973438795882 no 428 0.117213370812646 603 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1492 4158-0558 28.5 µM 1.18647059073151 0.110468727740242 no 429 0.117718254451665 606 3967268
SGTC_2892 9047358 58.44 µM 1.18638072267062 0.110486128386998 no 430 0.117735990534665 583 6466771
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.18593301465469 0.110572844848157 no 431 0.117824376985026 609 140250 A respiratory chain inhibitor.
SGTC_2133 5320837 200 µM 1.18307438260708 0.111127682946513 no 432 0.118389834736287 592 2841355
SGTC_2347 9049783 174.81 µM 1.17908213326142 0.111905879361484 no 433 0.119182736155524 689 6467988 YPL169C MEX67
SGTC_191 3914-0123 66.505 µM 1.17864035509621 0.111992232651468 no 434 0.119270707613517 491 3144412
SGTC_3136 9095672 49.47 µM 1.17845901950268 0.112027691661466 no 435 0.119306830303781 558 17217380
SGTC_2553 4-methylesculetin 85.09 µM 1.17330780280206 0.113038333540341 no 436 0.120336197180991 649 5319502
SGTC_681 1642-0006 26.6 µM 1.1730606038286 0.113086995780367 no 437 0.120385751749337 607 4446530
SGTC_3355 9151058 44.0485 µM 1.17288788312624 0.113121005505048 no 438 0.120420384612442 626 17015728
SGTC_1483 3453-0561 55.9 µM 1.17268460763257 0.113161040996674 no 439 0.12046115311754 686 4546991
SGTC_2534 helenine 20.12 µM 1.17013236833508 0.113664569852182 no 440 0.120973852181781 580 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_304 1310-0298 97 µM 1.16929723878518 0.113829678065361 no 441 0.12114194763283 659 1550234
SGTC_1718 roemerine 11.9335 µM 1.1657948986238 0.114523965033266 no 442 0.121848690131531 689 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2564 betulinic acid 100 µM 1.16501211573431 0.114679551383599 no 443 0.122007044314067 703 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2170 morpholine 200 µM 1.1632151697212 0.115037282137763 no 444 0.122371106637619 669 121171 Reacts with secondary amines.
SGTC_1300 1094-0077 113 µM 1.15720994177827 0.116238540507553 no 445 0.12359329844862 612 5532636
SGTC_1740 st038286 13.222 µM 1.15439252276364 0.116805181403567 no 446 0.12416963964228 658 716786
SGTC_689 0833-0039 98 µM 1.15336948404916 0.117011419339322 no 447 0.124379380635848 685 5374726
SGTC_1978 st071761 42 µM 1.15200303830717 0.117287288213681 no 448 0.124659912406462 621 5147680
SGTC_2031 5180455 200 µM 1.14635826089668 0.118431781762733 no 449 0.125823472760569 638 29949
SGTC_2197 6588183 93.1375 µM 1.1460404210042 0.118496458583503 no 450 0.125889213760383 618 884136
SGTC_3066 9117245 49.47 µM 1.14502408104773 0.118703439782071 no 451 0.126099591060562 699 17176980
SGTC_2375 9072683 200 µM 1.14084731971434 0.119556733242222 no 452 0.126966732505497 743 16798029
SGTC_572 0960-0087 17.7 µM 1.13452842583543 0.120855863920581 no 453 0.128286478490166 716 6796365
SGTC_1304 1165-0502 251 µM 1.13294256998878 0.121183461132798 no 454 0.128619185720141 721 767425
SGTC_1956 st077085 54 µM 1.1325457653035 0.121265528420416 no 455 0.128702527582894 720 24208685
SGTC_197 4544-0043 41.561 µM 1.13245217650134 0.121284890185054 no 456 0.128722189728583 704 896523
SGTC_2107 5363541 170.161 µM 1.13130067559569 0.121523292020971 no 457 0.128964280045314 696 244052
SGTC_2718 lomofungin 53.02 µM 1.12971639789854 0.121851832189335 no 458 0.129297872679651 651 5351222 A RNA synthesis inhibitor.
SGTC_448 monastrol 171 µM 1.12483687496029 0.122867643741661 no 459 0.130329082694475 674 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2115 tiliquinol 12.7705 µM 1.12150385857939 0.1235649102779 no 460 0.131036724997637 671 71208 A bioactive hydroxyquinoline.
SGTC_2292 7671323 168.05 µM 1.1213111562838 0.123605308141291 no 461 0.131077719196127 683 937504
SGTC_37 0566-0070 1.56 µM 1.12076162347085 0.123720562291983 no 462 0.131194671788883 732 1626686
SGTC_1822 st052468 42 µM 1.12041719190864 0.123792838668397 no 463 0.131268011085373 642 2873678
SGTC_566 0958-0068 16.5 µM 1.11992327405633 0.123896535196919 no 464 0.131373229676502 623 6815365
SGTC_2832 7992762 51.95 µM 1.11865628151146 0.124162814327796 no 465 0.131643401455876 580 2985177
SGTC_1320 1313-0481 95.3 µM 1.11557297798822 0.124812492704109 no 466 0.13230248209352 710 6813365 YLR208W SEC13
SGTC_1269 0831-0796 3.05 µM 1.11451649175806 0.1250356488103 no 467 0.1325288367173 687 927758
SGTC_1665 st014639 11.4 µM 1.11188424123524 0.12559285712434 no 468 0.133093962583985 742 981133 YIL048W NEO1
SGTC_460 trequinsin 123 µM 1.11062372553497 0.1258603021933 no 469 0.133365173003859 759 5537 A vasodilator.
SGTC_913 3487-1245 167 µM 1.11042696303027 0.125902085333965 no 470 0.133407542371448 675 4016153
SGTC_719 2810-4230 27.3 µM 1.10959971210793 0.126077860512346 no 471 0.133585777696922 653 721079
SGTC_854 0422-0053 192 µM 1.10835551277316 0.126342551383012 no 472 0.133854154857453 675 3596728
SGTC_3041 9091929 49.47 µM 1.10777931710481 0.126465262300055 no 473 0.133978567285213 720 25236887
SGTC_484 loperamide 105 µM 1.10753854150246 0.126516564253597 no 474 0.134030579193854 591 3955 An opioid-receptor agonist.
SGTC_752 1896-0090 130 µM 1.10720504340363 0.126587646493078 no 475 0.134102643761438 704 772567
SGTC_122 0236-0016 402.397 µM 1.10688757456933 0.126655338072176 no 476 0.134171269341775 768 6808838
SGTC_749 1000-0129 128 µM 1.10401119979018 0.127269795604524 no 477 0.1347941396926 751 708470
SGTC_1735 st034310 56.75 µM 1.09988726235073 0.128154373234312 no 478 0.13569062261159 699 871153
SGTC_2360 9040895 200 µM 1.09925628694587 0.128290092135633 no 479 0.135828146730255 644 4914414
SGTC_693 4161-2696 114 µM 1.09830988887125 0.128493843549408 no 480 0.136034597631062 653 805759
SGTC_2468 5987765 72.9 µM 1.09817429437682 0.128523054270408 no 481 0.13606419431702 736 26772094
SGTC_2364 9055074 200 µM 1.09713711895563 0.128746642365174 no 482 0.136290728036766 672 6470630
SGTC_591 4299-0174 154 µM 1.0971243298103 0.128749401056156 no 483 0.136293522975941 700 5509088
SGTC_3020 9089140 49.47 µM 1.09709187496898 0.128756401933071 no 484 0.136300615831355 678 17217859
SGTC_1195 1502-0147 41.1 µM 1.09159447344172 0.129946066579393 no 485 0.137505693180623 737 817940
SGTC_2231 micatex 6.853 µM 1.08729203587465 0.130882427743195 no 486 0.138453883580186 683 20737 An antifungal of unknown mechanism.
SGTC_2511 berberine 10.47 µM 1.0865165886041 0.131051686939214 no 487 0.138625252895368 717 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.08593675706437 0.13117834727598 no 488 0.138753486660649 684 688803
SGTC_2634 4'-methoxyflavone 100 µM 1.08340096758596 0.13173326691859 no 489 0.139315243194646 659 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_622 1348-1566 26.3 µM 1.08317539577535 0.131782708274018 no 490 0.139365289234747 775 7340407
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.08118231392532 0.132220112914212 no 491 0.139808011815926 736 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1131 3454-3128 32.3 µM 1.07982872016347 0.13251774463331 no 492 0.140109229670916 759 710982
SGTC_400 oxethazaine 37.5 µM 1.07712641940101 0.133113313428737 no 493 0.140711895827278 696 4621 A local anesthetic.
SGTC_778 3456-2434 196 µM 1.07684480089755 0.133175486069675 no 494 0.14077480335257 819 5539063
SGTC_275 trichlorophene 5.69 µM 1.07393304977628 0.133819482020679 no 495 0.1414263446552 858 62616
SGTC_3085 9117376 49.47 µM 1.07170689446532 0.134313285439071 no 496 0.141925851575474 716 16480349
SGTC_798 1287-0182 476 µM 1.0712194916915 0.134421567373923 no 497 0.14203537468944 797 1649755
SGTC_1073 triclabendazole 3.09 µM 1.0710862982565 0.134451168198151 no 498 0.14206531421926 788 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.06929485837573 0.134849731557807 no 499 0.142468413355534 808 5024745
SGTC_1690 st023502 41.2 µM 1.06852587015811 0.135021066094197 no 500 0.142641683591712 714 24207482
SGTC_2280 7785178 200 µM 1.06666038358421 0.135437326318099 no 501 0.143062611315033 718 2954328
SGTC_1495 4469-0029 237 µM 1.06657176900749 0.135457121419833 no 502 0.143082627133947 836 793680
SGTC_2404 5161160 200 µM 1.06566921157018 0.135658851482353 no 503 0.143286600076837 772 2831543
SGTC_3200 9114385 49.47 µM 1.06270462289751 0.136322912583769 no 504 0.143957961880348 686 17018030 YLR208W SEC13
SGTC_678 1218-2179 85.9 µM 1.06175361815397 0.136536405844515 no 505 0.144173775501436 693 6820081 YOR116C RPO31
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.06052287281304 0.136813038011268 no 506 0.144453394936955 746 688798
SGTC_545 4218-0007 221 µM 1.06010121463858 0.136907901328446 no 507 0.144549277642322 708 2840508
SGTC_1650 st011916 45.8 µM 1.05748979565315 0.137496411331479 no 508 0.145144054654285 749 242528
SGTC_1782 st039423 80.636 µM 1.05536743219099 0.137975978085125 no 509 0.145628655894557 691 2068169
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.05291709218029 0.138531071471636 no 510 0.146189495868809 797 6708784 An antioxidant flavonoid
SGTC_2693 st077581 40.7 µM 1.0519289909752 0.138755343181231 no 511 0.146416064853958 840 25238761
SGTC_2232 chlorophetanol 41.5365 µM 1.05099874737373 0.138966708690511 no 512 0.146629582573649 865 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1454 4239-0054 42.6 µM 1.04992915724592 0.139210006644981 no 513 0.146875342465555 809 1340767
SGTC_1184 1269-1718 139 µM 1.04871585489029 0.139486345307717 no 514 0.147154457429105 761 5403821
SGTC_1065 prochlorperazine maleate 2.48 µM 1.04583201487767 0.140144657887853 no 515 0.147819298602898 774 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.04466485073458 0.140411692923582 no 516 0.148088947735547 743 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2222 6885208 172.143 µM 1.04408451546597 0.140544596120352 no 517 0.148223144647646 732 609514
SGTC_2047 4141938 200 µM 1.04353000644217 0.140671664574883 no 518 0.14835144547874 701 3807862
SGTC_712 r015-0009 80.6 µM 1.04177027717767 0.141075431347563 no 519 0.148759098782769 704 6813872 YLR060W FRS1
SGTC_1882 5615643 20 µM 1.04157799162855 0.141119598510529 no 520 0.148803688374744 728 2253075
SGTC_2142 5622915 118.518 µM 1.04064377235887 0.141334318090192 no 521 0.149020454001825 726 5322196
SGTC_3155 9099265 49.47 µM 1.04062642682618 0.141338306854702 no 522 0.149024480655806 710 25236499
SGTC_3015 9080845 49.47 µM 1.04052705214496 0.141361160445909 no 523 0.14904755125066 817 5296973
SGTC_2358 9037157 4 µM 1.04005029329881 0.141470837407671 no 524 0.149158267653849 761 2388925
SGTC_3331 9141060 1.957 µM 1.03949166619312 0.141599421269369 no 525 0.14928806596582 718 4906567 YPR165W RHO1
SGTC_3273 9137859 49.47 µM 1.03701384899534 0.142170715413013 no 526 0.149864701483522 762 2377234
SGTC_2795 7780010 54.55 µM 1.03596045311756 0.142414061920552 no 527 0.150110296291739 716 953673
SGTC_751 0833-0568 350 µM 1.03561496005465 0.142493936097325 no 528 0.150190904940235 762 6954252
SGTC_2417 cerulenin 830 nM 1.03463682250901 0.142720234978521 no 529 0.150419275361227 747 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_190 3970-0790 3.722 µM 1.03175157398954 0.143389171941321 no 530 0.151094255105352 744 2832352
SGTC_347 4534-1311 26.2 µM 1.02520549104462 0.144914702810842 no 531 0.152633118934869 771 2862016
SGTC_2699 st077704 54.6 µM 1.0235297130877 0.145306984544759 no 532 0.153028729287487 771 645852
SGTC_615 k087-0205 167 µM 1.02048303322185 0.146022008377758 no 533 0.153749715978987 734 9642773
SGTC_2153 5569715 200 µM 1.01954233503158 0.14624325719988 no 534 0.15397278269141 772 2054701
SGTC_1915 st067105 30.6 µM 1.01915579948055 0.14633423419323 no 535 0.154064503479688 761 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2063 5246145 200 µM 1.01840147739336 0.146511884736627 no 536 0.154243600193177 796 711240
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.01806225506066 0.146591822224 no 537 0.154324185726119 779 5379071
SGTC_1189 1431-2119 7.28 µM 1.01801365081043 0.14660327817596 no 538 0.154335734413805 815 3107275
SGTC_1963 st076565 50.3 µM 1.01290185712735 0.14781147557371 no 539 0.155553520628876 777 4914280
SGTC_2007 4011539 71.82 µM 1.01132708966732 0.148185019060663 no 540 0.155929952286917 780 45595301
SGTC_2072 5231554 129 µM 1.01087286715238 0.148292880400491 no 541 0.156038640905392 840 789545
SGTC_3014 9081533 49.47 µM 1.01052873662826 0.148374633853447 no 542 0.156121019401015 823 21367265
SGTC_2084 5306078 60.6385 µM 1.00765884117062 0.149057595130666 no 543 0.15680913525615 770 679340
SGTC_674 0498-0004 451 µM 1.0074628065112 0.149104322831106 no 544 0.156856211266521 757 4231473
SGTC_1801 st050089 28.441 µM 1.00678444955647 0.149266094536996 no 545 0.157019184519844 878 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2325 6158266 200 µM 0.999408934563384 0.151032538895273 no 546 0.158798316730637 772 3623240
SGTC_1027 k015-0025 8.67 µM 0.996222941219618 0.151799873099911 no 547 0.159570917575103 794 3598955
SGTC_2304 7443016 91.4 µM 0.993436363348691 0.1524731296878 no 548 0.160248674019824 742 939854
SGTC_2343 7990716 14.84 µM 0.993429815638167 0.152474713990127 no 549 0.160250268778247 817 6456862
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.992438890127107 0.152714607026504 no 550 0.160491737879003 857 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2671 danthron 100 µM 0.989659220198886 0.153388872421384 no 551 0.161170356854701 803 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2408 sulbentine 18.36 µM 0.989178208261446 0.153505751490931 no 552 0.161287979179987 798 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3291 9121177 71.43 µM 0.98631705835167 0.154202188876388 no 553 0.161988775756361 721 17015612
SGTC_3344 9148862 3.898 µM 0.984626387497349 0.154614698717428 no 554 0.16240381160111 834 4905352
SGTC_859 0439-0102 54.6 µM 0.982578294388814 0.155115392620245 no 555 0.162907515768782 882 610143
SGTC_1035 k081-0041 55.2 µM 0.981544277871216 0.155368583123187 no 556 0.163162205307901 850 731709
SGTC_2665 lovastatin 100 µM 0.98088467242843 0.155530237283644 no 557 0.16332480842793 792 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_944 3370-0224 231 µM 0.980146029353607 0.155711393404393 no 558 0.163507020476248 810 4580514
SGTC_3104 9120930 49.47 µM 0.975557718995785 0.156839816477584 no 559 0.164641842835479 762 17014836
SGTC_2149 5554786 194.827 µM 0.975442366559616 0.156868254770129 no 560 0.164670438451046 855 745063 YPR165W RHO1
SGTC_3211 9128781 49.47 µM 0.974382992441186 0.157129585113237 no 561 0.164933205437543 770 17194361
SGTC_486 niguldipine 82 µM 0.973610906596395 0.157320226386282 no 562 0.165124884452984 793 1236 A calcium channel blocker.
SGTC_521 r062-0005 13.8 µM 0.971795823130717 0.157769000374915 no 563 0.165576067115259 802 2832033
SGTC_2301 7769476 200 µM 0.970910714762156 0.157988145477143 no 564 0.165796371017349 794 977820
SGTC_1548 st061468 90.8 µM 0.968633675851154 0.158552838388251 no 565 0.1663639974726 865 390799
SGTC_1889 st059080 5.18 µM 0.965685226632597 0.159286001540931 no 566 0.167100857066566 888 176925 Isolated from Daphnopsis sellowiana.
SGTC_1049 3226-0134 66 µM 0.965216869810834 0.159402667448327 no 567 0.167218099520677 868 5702385
SGTC_885 0865-0106 16.8 µM 0.964647288185586 0.159544623440181 no 568 0.167360752734645 823 2793380
SGTC_2680 butyl paraben 22.24 µM 0.963846448636651 0.159744355420987 no 569 0.167561457714287 824 7184 An antifungal and steroid mimetic.
SGTC_312 4092-0653 6.84 µM 0.963113344748726 0.159927337272564 no 570 0.16774532277652 913 1148278
SGTC_3292 9120825 59.784 µM 0.961369801233587 0.160363074144826 no 571 0.168183131389981 871 24824900
SGTC_3188 9110789 49.47 µM 0.960452903869504 0.160592531103776 no 572 0.168413661547849 837 849217
SGTC_2934 9036370 36.88 µM 0.959821934438646 0.160750558045016 no 573 0.168572420487586 867 6462800
SGTC_520 3584-0023 682 µM 0.958930781363672 0.160973921166234 no 574 0.16879680837177 778 1340790
SGTC_950 1165-0508 94.1 µM 0.958670609186104 0.161039170224104 no 575 0.16886235460295 774 6148369
SGTC_1596 piperlongumine 63 µM 0.958593626604222 0.161058480135774 no 576 0.168881752271577 901 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1019 4262-0212 3.4 µM 0.958300609351881 0.161131992884584 no 577 0.168955598321264 925 4677213
SGTC_3204 9114183 49.47 µM 0.958066946056962 0.161190630482964 no 578 0.169014500881618 790 17027248
SGTC_1305 1181-0477 144 µM 0.955590676877423 0.161812903470165 no 579 0.169639536789916 844 6252086
SGTC_509 pifithrin 175 µM 0.953407704350738 0.162362769082392 no 580 0.17019176968465 909 4817 A p53 inhibitor.
SGTC_1730 st033808 45.1 µM 0.952874060892717 0.162497372499555 no 581 0.170326942034399 929 1045166
SGTC_1867 st057372 64 µM 0.95133900860957 0.162884970753094 no 582 0.17071615542337 841 688837
SGTC_63 0099-0242 26.702 µM 0.950610630825471 0.163069095104033 no 583 0.170901035015275 918 3898502 YLR359W ADE13
SGTC_1812 st052057 4.327 µM 0.950246723533847 0.163161136754098 no 584 0.170993451306301 881 3645418
SGTC_797 k781-0471 270 µM 0.94978427088419 0.163278151800424 no 585 0.171110939860298 867 23738129
SGTC_356 1634-0012 32.5 µM 0.948735709055236 0.163543672798416 no 586 0.171377523760225 885 735457
SGTC_233 rapamycin 362 pM 0.947448035281178 0.163870126046901 no 587 0.171705261906279 916 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2635 hydroquinidine 100 µM 0.94726530579543 0.163916486176919 no 588 0.171751802549346 853 442912 An experimental heart treatment.
SGTC_1628 st004252 77.7 µM 0.947208042956773 0.163931016030358 no 589 0.171766388877781 865 692968
SGTC_1196 1588-0294 184 µM 0.947099653016402 0.16395852114542 no 590 0.171794000769645 810 6144269
SGTC_1530 rhein 70.4 µM 0.947072651249408 0.163965373600546 no 591 0.171800879799861 916 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3124 9127567 49.47 µM 0.94622233434535 0.164181260406704 no 592 0.172017598420743 825 17592030
SGTC_1283 0922-0125 16.4 µM 0.945456376456844 0.164375887068624 no 593 0.172212965962397 922 3360884
SGTC_543 3844-1095 191 µM 0.944777191179608 0.164548590241724 no 594 0.172386319409187 887 4230703
SGTC_550 4123-0385 25.7 µM 0.944398604144601 0.164644908344799 no 595 0.172482997258636 846 5731123
SGTC_3314 9135860 59.4275 µM 0.944309542047158 0.164667572357438 no 596 0.172505745617605 894 25252478
SGTC_291 SEC14.278 35.5 µM 0.942860021954292 0.165036722080327 no 597 0.172876252917358 876 1068044
SGTC_2621 lithochol-11-enic acid 100 µM 0.941052168790637 0.165497878844631 no 598 0.173339062699287 893 6708711
SGTC_2485 5633444 17.78 µM 0.940867551274804 0.165545018919871 no 599 0.173386369068421 823 5724239
SGTC_2903 5923464 63.88 µM 0.939087903576244 0.165999877905662 no 600 0.173842807166154 853 2876576
SGTC_1478 0453-0656 35.7 µM 0.938547870425853 0.166138064190355 no 601 0.173981464058354 887 5258496
SGTC_68 0986-0284 82.829 µM 0.937783120859047 0.166333879087909 no 602 0.174177938554415 707 423278 YIL048W NEO1
SGTC_3002 9075603 71.4286 µM 0.936842954682595 0.166574813736537 no 603 0.174419673108461 899 20105405
SGTC_1753 st043925 64 µM 0.934746017547468 0.167113003000718 no 604 0.174959602749056 898 670181
SGTC_175 3793-3120 23.7 µM 0.93125149614951 0.168012377181498 no 605 0.175861742792645 827 5322297
SGTC_3022 9087993 49.47 µM 0.926673150741323 0.169195396845848 no 606 0.177048130933865 892 17173644
SGTC_1780 st038448 24.544 µM 0.924815165844777 0.169677011989027 no 607 0.177531030219417 880 728868 YDL195W SEC31
SGTC_360 0957-0399 1.01 µM 0.923404711515202 0.170043207626743 no 608 0.177898168666284 903 6752301 YPR165W RHO1
SGTC_253 dyclonine 31.25 µM 0.922205271493236 0.170355015952984 no 609 0.178210756972836 946 3180 An oral anasthetic.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.921005306896704 0.170667326885136 no 610 0.178523828171259 960 688801
SGTC_1657 st012939 43.4 µM 0.920804618208399 0.170719595238025 no 611 0.178576221715619 853 24207257
SGTC_2472 5377652 49.4 µM 0.918698023361991 0.171268865334325 no 612 0.179126772001742 885 1610903
SGTC_3052 9092717 49.47 µM 0.918396759832561 0.171347508538428 no 613 0.179205593218251 858 25237534
SGTC_518 1021-0119 62.6 µM 0.918079267597157 0.17143041313662 no 614 0.179288684044682 819 1097762
SGTC_1068 loratadine 26.9 µM 0.91728849792538 0.171637012894509 no 615 0.1794957415064 862 3957 A H1 histamine antagonist.
SGTC_2386 9075165 157.42 µM 0.915257523311839 0.17216836229432 no 616 0.180028226324326 891 16452277
SGTC_1265 0819-1001 68.8 µM 0.915155062902877 0.172195196066715 no 617 0.180055115845336 860 3106768
SGTC_2844 9010103 25.97 µM 0.910734770766045 0.173355384950611 no 618 0.181217569404811 847 2480525
SGTC_463 ikarugamyin 104 µM 0.910477231913811 0.17342313394143 no 619 0.181285441868669 905 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3190 9110366 49.47 µM 0.910187222374392 0.173499444946772 no 620 0.181361890796001 812 17123768
SGTC_114 0364-0001 490.298 µM 0.90910294297998 0.173784943637671 no 621 0.181647894643303 888 4003655
SGTC_1563 conessine 56.1 µM 0.907687390775702 0.174158118321267 no 622 0.182021703858296 1023 441082 An anti-amoebic, histamine inhibitor.
SGTC_2470 5664817 21.68 µM 0.907408497106994 0.174231701625784 no 623 0.18209540884244 901 2859561
SGTC_1254 0550-0035 264 µM 0.906771879090467 0.174399740929373 no 624 0.182263721780757 945 15121435
SGTC_1276 0871-0068 94.2 µM 0.903440337747039 0.175280800464138 no 625 0.183146119771783 895 3414906
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.902941998379122 0.175412833567477 no 626 0.183278339563743 948 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2682 pyrogallin 40.03 µM 0.90274878706832 0.175464041119612 no 627 0.183329618549276 982 822798 An ATP competetive kinase inhibitor.
SGTC_1480 1070-0044 41.2 µM 0.9014737458228 0.175802207863795 no 628 0.183668243411032 922 3124987
SGTC_1789 tunicamycin 25 nM 0.901388352253854 0.175824870707169 no 629 0.183690936111138 905 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1198 1612-1005 86.7 µM 0.901046602047019 0.175915587292271 no 630 0.183781771147677 928 6998509
SGTC_840 0245-0196 390 µM 0.898886666644448 0.176489621257704 no 631 0.184356515336267 950 3827528
SGTC_1024 4507-0395 26 µM 0.895911264944455 0.177282314975973 no 632 0.185150078610247 869 4201836
SGTC_2775 cyproheptadine 69.59 µM 0.892303504661598 0.178246489706631 no 633 0.186115138140449 961 2913 A selective serotonin reuptake inhibitor.
SGTC_3149 9097855 49.47 µM 0.891630119774313 0.178426817272936 no 634 0.186295610228676 894 25236625 YMR079W SEC14
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.890959921147667 0.178606405655085 no 635 0.186475335997444 892 5355888
SGTC_2906 7926292 26.41 µM 0.888905600175363 0.179157596413581 no 636 0.18702690773985 928 2966319
SGTC_2040 5100729 123 µM 0.88883800206883 0.179175751691182 no 637 0.187045074524367 933 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_695 3505-6186 243 µM 0.888448699208836 0.179280331897765 no 638 0.187149719722648 924 1819379
SGTC_1990 st072050 59.8 µM 0.88724278927797 0.179604524545433 no 639 0.187474099866488 931 17233948
SGTC_1968 st069590 43.6 µM 0.886444736609331 0.17981927270938 no 640 0.187688960612919 906 6384066
SGTC_2467 5474540 200 µM 0.885214512872826 0.180150629686608 no 641 0.18802047318131 941 5413519
SGTC_3125 9127534 49.47 µM 0.882501660996607 0.180882681456458 no 642 0.188752790967703 832 1639235
SGTC_1569 carminic acid 40.6 µM 0.882271577848366 0.180944854087277 no 643 0.188814981274662 970 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2152 5568786 200 µM 0.881542603957437 0.181141924441837 no 644 0.189012102583443 915 5399883
SGTC_1924 st058459 75.1 µM 0.881212952612415 0.181231086314407 no 645 0.189101284976911 921 688683
SGTC_2673 kobusone 100 µM 0.881108963970694 0.181259218162822 no 646 0.18912942297276 973 6710676 An epoxy ketone and protein crosslinker.
SGTC_2723 salbutamol 83.58 µM 0.880843114899732 0.181331150235445 no 647 0.189201370050723 862 9884233 β2-adrenoceptor agonist
SGTC_2507 purpurin 79.67 µM 0.880240683346079 0.181494219197355 no 648 0.189364469233713 963 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3079 9117512 49.47 µM 0.87994371683759 0.181574637233185 no 649 0.189444900235164 997 7185044
SGTC_2980 9014342 25.29 µM 0.878035950287639 0.182091788890149 no 650 0.189962104741501 854 2996599
SGTC_2812 7970281 58.44 µM 0.877547717375531 0.182224285446609 no 651 0.190094606349825 949 2233435
SGTC_2964 9083345 53.42 µM 0.875723127316886 0.182719975513095 no 652 0.190590284694743 878 17741579
SGTC_848 0368-0089 85.6 µM 0.873518805136782 0.183319949873031 no 653 0.191190180415419 959 762535
SGTC_1379 2144-0755 36.5 µM 0.872714315695977 0.18353922214234 no 654 0.191409406388312 1005 5392327
SGTC_2465 5809242 33.21 µM 0.86853789140497 0.184680176801188 no 655 0.192549969197088 961 2731748
SGTC_1013 4112-3890 241 µM 0.867255555606387 0.185031380263168 no 656 0.19290100128053 898 705171
SGTC_979 1426-2828 121 µM 0.866879241166066 0.185134523178691 no 657 0.193004089343168 985 747872
SGTC_2076 5212012 200 µM 0.86686849540875 0.185137468975988 no 658 0.193007033543728 860 604802
SGTC_2714 st079313 56.9 µM 0.866638201767844 0.185200607716376 no 659 0.193070137658441 935 2939799
SGTC_557 1315-0110 16.2 µM 0.866516565297189 0.185233961725854 no 660 0.19310347306638 1002 6833801
SGTC_2233 sulbentine 40.3845 µM 0.864345159498202 0.185830011759685 no 661 0.193699154608582 979 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2617 dihydrotanshinone i 20.83 µM 0.863106241693241 0.186170626579427 no 662 0.194039528245801 978 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_890 0929-0006 47.2 µM 0.862330509778204 0.186384094876466 no 663 0.194252834074767 923 1378169
SGTC_2265 7929201 200 µM 0.861880017548547 0.186508132283335 no 664 0.194376773079893 1013 1265108
SGTC_2931 9014674 55.67 µM 0.861845291985879 0.186517695654899 no 665 0.194386328742682 963 2996810
SGTC_3113 9123498 49.47 µM 0.860965068163304 0.186760209472153 no 666 0.194628641247498 1021 8897275
SGTC_2310 7668677 200 µM 0.860349460012718 0.186929933947957 no 667 0.194798218169591 922 2197143
SGTC_3145 9085516 49.47 µM 0.859140976289761 0.187263392940354 no 668 0.195131371308912 924 25236195
SGTC_3077 9117319 49.47 µM 0.857408387430761 0.187742110359499 no 669 0.195609612762655 957 17154678
SGTC_1837 st055472 66.5 µM 0.857088949915952 0.187830453979281 no 670 0.195697863805138 966 676091
SGTC_150 3970-0969 77.2 µM 0.856381305290442 0.188026251544192 no 671 0.195893450933227 975 6615640
SGTC_932 2857-0803 154 µM 0.855708913745605 0.188212411653031 no 672 0.196079404253111 1017 674898
SGTC_1638 st008370 60.6 µM 0.855672251326914 0.188222565376231 no 673 0.196089546509498 948 24207134
SGTC_2166 5933061 31.504 µM 0.853516840242523 0.188820104313677 no 674 0.196686376463419 1027 2877375
SGTC_88 0180-0332 8.668 µM 0.852935757694557 0.188981396139028 no 675 0.196847465418787 1037 3101745
SGTC_690 glyoxal 20.3 µM 0.85271645057043 0.189042291552183 no 676 0.196908282970388 919 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_715 0868-0130 184 µM 0.850187210322656 0.189745463543992 no 677 0.197610505623212 971 2876258
SGTC_2954 9074818 52.69 µM 0.849717863804377 0.189876126620858 no 678 0.197740982124944 938 16648742
SGTC_441 propafenone 146 µM 0.845062916069958 0.191175027652498 no 679 0.199037856002067 979 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2359 9039622 200 µM 0.844695951116939 0.191277655464253 no 680 0.199140310336765 1009 6463596
SGTC_1074 carmofur 3.8 µM 0.844429783345068 0.19135211480515 no 681 0.199214642599415 1057 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_401 neomycin 50 µM 0.843926215489596 0.191493034431663 no 682 0.199355318924825 951 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3221 9128209 49.47 µM 0.842455786164863 0.191904886638431 no 683 0.199766439114314 951 16460723
SGTC_172 1112-0046 2.638 µM 0.842296402043214 0.191949561048187 no 684 0.199811032247051 881 2802135 YIL048W NEO1
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.842066955722047 0.192013884647278 no 685 0.199875238177658 1032 5282309
SGTC_508 roscovitine 141 µM 0.840440908181166 0.192470113091271 no 686 0.200330610271404 1010 160355 A CDKinase inhibitor.
SGTC_1838 st055369 84.5 µM 0.840223477725428 0.192531168856761 no 687 0.200391548543844 1004 676036
SGTC_110 0850-0284 111.64 µM 0.840109888068066 0.19256307021602 no 688 0.20042338824251 860 3906265
SGTC_2963 9082507 9 µM 0.837277253287785 0.193359652887405 no 689 0.201218371051226 922 16459611
SGTC_771 0250-0039 27.3 µM 0.835243779216053 0.193932736569781 no 690 0.201790232399672 955 3005115
SGTC_2779 methotrexate 400 µM 0.833605441386084 0.194395213104584 no 691 0.202251679169776 1080 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2689 tacrolimus 100 µM 0.833161015577227 0.194520783070928 no 692 0.202376962873245 964 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_391 gliotoxin 8.33 µM 0.832539912079919 0.194696354989257 no 693 0.20255212977517 1022 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_413 propylparaben 100 µM 0.832315088757143 0.194759931218075 no 694 0.202615557975078 954 7175 A pharmaceutical preservative.
SGTC_2018 5133068 143 µM 0.832309259886214 0.194761579692008 no 695 0.202617202601082 934 785362
SGTC_3196 9111891 49.47 µM 0.831096760174523 0.195104673502613 no 696 0.202959484917965 1014 18891510
SGTC_1112 tnp00069 1.16933 µM 0.829808356921335 0.195469647597631 no 697 0.203323572577582 1040 145826
SGTC_499 genistein 192 µM 0.829428097522536 0.195577445271032 no 698 0.20343110387153 1014 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2418 pentamidine 31.67 µM 0.828452765745084 0.195854101768444 no 699 0.203707067211991 1010 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_123 0083-0120 66.675 µM 0.82714962028015 0.196224114246863 no 700 0.204076131276792 990 16001701
SGTC_1135 dihydrocapsaicin 536.708 nM 0.824811619438281 0.196889022930584 no 701 0.204739274443334 928 107982 A Capsaicinoid.
SGTC_616 4092-0450 108 µM 0.824746918087264 0.196907442851768 no 702 0.20475764433732 1024 787165
SGTC_2875 9039966 71.43 µM 0.824657638945955 0.196932861572576 no 703 0.204782993923946 1030 6463691
SGTC_209 4077-0173 175.592 µM 0.824411262603783 0.19700301784085 no 704 0.204852958786245 911 15993494
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.823118957399357 0.197371252633949 no 705 0.205220174646043 1035 4213774
SGTC_1436 4092-1007 8.32 µM 0.823034340007947 0.197395378375648 no 706 0.20524423279323 999 2881121
SGTC_165 k038-0023 64.381 µM 0.819029828969558 0.198539165449432 no 707 0.20638469758618 1052 46368543
SGTC_3119 9125183 49.47 µM 0.81900891486033 0.198545149509465 no 708 0.206390663660331 877 22695334
SGTC_1188 1403-0014 4.57 µM 0.818441398592018 0.198707571915749 no 709 0.206552595489135 1043 9614867
SGTC_1257 0669-0121 16 µM 0.817878291400259 0.198868811613098 no 710 0.206713343614356 1099 4307855
SGTC_3334 9142812 21.919 µM 0.817447169818085 0.198992311935458 no 711 0.206836464346642 985 45283678
SGTC_1248 0469-0687 58.6 µM 0.814316716411108 0.199890455982473 no 712 0.207731767866601 1006 4017482
SGTC_1482 3346-2049 8.48 µM 0.813887901914248 0.200013674748929 no 713 0.207854585990857 1005 3826804
SGTC_1119 parthenolide 318.541 nM 0.80910260468615 0.201391813738108 no 714 0.209228065087688 1076 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1959 st077091 55.8 µM 0.805954170427122 0.202301641473106 no 715 0.210134637422178 1081 821356 YKL052C ASK1
SGTC_2717 st081029 62.2815 µM 0.804929389668464 0.202598309916536 no 716 0.210430213777054 1019 5292846
SGTC_24 0417-1663 219 µM 0.803850278259177 0.202910987704138 no 717 0.210741724312545 1042 4329390
SGTC_339 3091-4833 71.4 µM 0.803369325048347 0.203050439049184 no 718 0.210880649712392 1027 3240077
SGTC_937 3122-0005 46.7 µM 0.802640767374158 0.203261791740339 no 719 0.211091198984549 1066 759535
SGTC_1606 st000094 49.2 µM 0.802618621247421 0.203268218329751 no 720 0.211097601025702 1088 1242210
SGTC_1572 epiandrosterone 68.9 µM 0.802423765811699 0.203324768698965 no 721 0.211153935082096 1032 441302 A steroid.
SGTC_473 2-arachidonoylglycerol 10 µM 0.799988756573585 0.20403224126866 no 722 0.211858655723702 968 5282280 An endocannabinoid.
SGTC_3252 9135871 49.47 µM 0.799150504862108 0.204276127567233 no 723 0.212101573759724 1062 17682838
SGTC_842 0271-0008 11.1 µM 0.794917790927439 0.205510269075517 no 724 0.213330662284008 1071 1221709
SGTC_1877 wortmannin 25 µM 0.793165580442314 0.206022457792531 no 725 0.213840679113621 1076 312145 A covalent inhibitor of PI 3-kinase.
SGTC_293 4049-0273 38.5 µM 0.791853401685654 0.206406516086266 no 726 0.214223080191952 988 1380311
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.791511867209017 0.206506548485507 no 727 0.214322676928506 1111 66535 A nucleotide analog.
SGTC_310 1273-0058 1.06 µM 0.790251886975707 0.20687583377371 no 728 0.214690339533086 1125 2734232
SGTC_1181 1222-0449 220 µM 0.78859107075875 0.207363196039879 no 729 0.215175525738192 1057 658318
SGTC_1459 k035-0031 35.7 µM 0.788370302001671 0.207428031140609 no 730 0.215240068396563 927 3877128 YMR208W ERG12
SGTC_1327 1436-0082 2.18 µM 0.788366410504073 0.207429174098368 no 731 0.21524120619273 1017 15992205
SGTC_799 1310-0557 151 µM 0.788256690611263 0.207461401065525 no 732 0.215273287534419 1040 5354492
SGTC_3120 9124077 49.47 µM 0.787336907022513 0.207731676612486 no 733 0.215542335040909 1143 18774327 YGL155W CDC43
SGTC_2437 5741531 144.16 µM 0.78317461592693 0.208957350644759 no 734 0.216762289526783 1128 2262990
SGTC_1042 0350-0096 82 µM 0.782587044388276 0.209130715885698 no 735 0.216934825934018 1031 3122515
SGTC_272 doxorubicin 8.13 µM 0.78238725251596 0.209189684534635 no 736 0.216993511545879 1110 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_270 tamoxifen 5.46 µM 0.782231554898424 0.209235645532994 no 737 0.217039251548319 1124 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2930 9013230 14.89 µM 0.779602956267056 0.21001248891609 no 738 0.217812307646365 1076 2995857
SGTC_1781 st038725 66.3 µM 0.778186954191891 0.210431668772888 no 739 0.218229403265526 1083 4270275 YIL048W NEO1
SGTC_2260 7964312 200 µM 0.777627140080608 0.210597526218903 no 740 0.218394428196473 1011 231951
SGTC_872 0588-0139 234 µM 0.777131946256383 0.210744302376629 no 741 0.218540463914485 1106 2047100
SGTC_32 0928-0142 34.1 µM 0.776542981802894 0.21091895038388 no 742 0.218714226352837 1067 2244242
SGTC_1375 2910-0797 186 µM 0.77571349206067 0.211165066197706 no 743 0.218959085877811 1051 742508
SGTC_44 0929-0055 61.211 µM 0.772381623412678 0.212155350732719 no 744 0.219944217295946 1039 1379590
SGTC_2881 9058953 51.95 µM 0.772169360573498 0.212218530496258 no 745 0.220007062967454 1099 17122249
SGTC_656 4090-1979 187 µM 0.77118933828589 0.212510375460356 no 746 0.220297356402183 1126 22330961
SGTC_1203 3992-3522 103 µM 0.77036781582185 0.212755200632569 no 747 0.22054086954854 1138 5322312
SGTC_2236 dapsone 200 µM 0.76871157658776 0.213249283389135 no 748 0.221032275483518 1131 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_721 1187-1332 279 µM 0.766881049198656 0.213796136731365 no 749 0.221576120992413 978 25730
SGTC_1418 3966-3099 2.4 µM 0.765754871922041 0.214132977296883 no 750 0.221911085330344 1097 740335
SGTC_2185 6113692 200 µM 0.764785619245569 0.214423128694687 no 751 0.222199606226628 1071 874150
SGTC_3158 9100007 49.47 µM 0.764104563284702 0.214627143427722 no 752 0.222402466571765 1089 19297233
SGTC_817 1391-0715 46 µM 0.763792862289155 0.214720553104931 no 753 0.222495345521348 1046 1353946
SGTC_2703 st077852 53.4 µM 0.762973969273699 0.214966069186286 no 754 0.222739460120198 1053 6281836
SGTC_300 r073-0011 5.04 µM 0.762156310891047 0.21521137769373 no 755 0.222983358895271 1138 2735780
SGTC_341 1486-1430 230 µM 0.761975767938897 0.215265564897014 no 756 0.223037233426835 1094 2054753 YPL210C SRP72
SGTC_2799 7812892 81.82 µM 0.76168248422381 0.215353606390468 no 757 0.223124765922899 1092 20205235
SGTC_983 1491-0821 12.2 µM 0.76033519421235 0.215758320730684 no 758 0.22352712489809 1082 46495113
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.759881873871123 0.215894593327238 no 759 0.223662598662639 1102 2333 A French combination drug.
SGTC_880 0833-0487 87.2 µM 0.7598346820727 0.215908782516211 no 760 0.223676704508066 1097 76075
SGTC_741 4582-0002 126 µM 0.757841766783381 0.216508486735513 no 761 0.224272857592034 1073 2912688
SGTC_155 k072-0202 43.6 µM 0.757796497180318 0.216522120362844 no 762 0.224286409838732 1063 5857737
SGTC_3317 9138495 8.753 µM 0.757255206974785 0.216685176589596 no 763 0.224448490531156 1126 17020139
SGTC_2802 7925815 54.55 µM 0.756680621506012 0.216858340237326 no 764 0.224620613663474 1089 1262923
SGTC_48 0382-0018 55 µM 0.756324899664617 0.216965584723659 no 765 0.22472721140576 1184 762596
SGTC_1742 st038235 28.8875 µM 0.753988175614465 0.217670831558419 no 766 0.225428160958512 1064 564103 YBR002C RER2
SGTC_1315 1237-0019 3.69 µM 0.753062677610108 0.217950521442253 no 767 0.225706125384886 1112 825140
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.751096059023304 0.218545530400992 no 768 0.226297423669754 1019 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.750560423543941 0.218707751143913 no 769 0.22645862334114 1132 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.750526118167119 0.218718143114784 no 770 0.22646894976431 1154 6728940
SGTC_2124 5246320 200 µM 0.750016661421601 0.218872503960408 no 771 0.2266223350305 1075 579342
SGTC_2945 9067681 61.76 µM 0.74974859237252 0.218953751648681 no 772 0.226703067761494 1172 16456930
SGTC_1151 3909-8316 15.3 µM 0.74786542753217 0.219524999310054 no 773 0.227270666372971 1106 800431
SGTC_1231 0242-0792 125 µM 0.747713198908476 0.219571214391604 no 774 0.227316584066924 1116 3707635
SGTC_1712 st032288 53.4 µM 0.746416124103918 0.219965219862472 no 775 0.227708040994063 1138 2883011
SGTC_2982 9019404 25.97 µM 0.745014104152415 0.220391559846459 no 776 0.228131596772205 1039 22333232
SGTC_142 0335-0849 62.6745 µM 0.743097315219093 0.220975201574579 no 777 0.228711382490053 1141 3889043 YPR107C YTH1
SGTC_2601 securinine 100 µM 0.742020345981134 0.221303514981228 no 778 0.229037504231181 1110 442872 A GABA receptor antagonist.
SGTC_71 0417-1750 47.813 µM 0.740896348985343 0.221646462096578 no 779 0.229378144694142 1120 6811472
SGTC_2663 amphotericin b 100 µM 0.739806520587179 0.221979273694217 no 780 0.229708700947251 1123 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3166 9102297 49.47 µM 0.739678010244242 0.222018536957277 no 781 0.22974769704361 1095 25237072
SGTC_1981 st071826 47 µM 0.739542672795623 0.222059890365412 no 782 0.229788768813306 1093 11838600
SGTC_835 0312-0010 67.2 µM 0.736625845162711 0.222952217660537 no 783 0.230674956705738 1107 1626196
SGTC_3332 9141069 11.198 µM 0.735483697666822 0.223302183576498 no 784 0.23102248242213 1112 17332883
SGTC_3131 9127911 49.47 µM 0.733177657560775 0.224009730334616 no 785 0.231725040229139 1151 45595681
SGTC_1574 spiramycin 23.7 µM 0.730170377753061 0.224934344405197 no 786 0.232643023427875 1173 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_728 3030-5151 22.5 µM 0.727739822163804 0.225683217717553 no 787 0.233386434186777 1129 3125388
SGTC_3091 9116372 49.47 µM 0.726862896357705 0.225953751337822 no 788 0.23365497427502 1154 17169793
SGTC_106 0092-0003 11.579 µM 0.726552956581597 0.226049412304713 no 789 0.233749927772134 1097 1072148
SGTC_3349 9149703 23.001 µM 0.726215726946975 0.226153522114605 no 790 0.233853266112755 1158 4910494
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.724532292450184 0.226673638446709 no 791 0.234369504687492 1188 1377
SGTC_1438 4092-1045 4 µM 0.723821224670815 0.226893533598474 no 792 0.234587748582716 1159 1351342
SGTC_3165 9101544 49.47 µM 0.723446414065709 0.227009490839335 no 793 0.234702832244435 1137 5002184
SGTC_2087 5276107 200 µM 0.721187430177778 0.227709072450936 no 794 0.235397102207867 1166 144405
SGTC_1404 3909-7820 48.3 µM 0.72067486019136 0.227867978297693 no 795 0.235554791700678 1139 23741373
SGTC_575 k072-0246 11.9 µM 0.719826385353302 0.228131157723292 no 796 0.23581594860748 1161 6796779
SGTC_93 0109-0045 59.227 µM 0.71558153545589 0.229450386192237 no 797 0.237124889164136 1255 88733
SGTC_1162 k048-0130 20.1 µM 0.7119211419292 0.230591400004815 no 798 0.238256804707627 1148 6797406
SGTC_2368 9071271 200 µM 0.711904780081151 0.23059650740994 no 799 0.238261870971925 1156 27209959
SGTC_424 splitomicin 100 mM 0.708865508245018 0.231546321918062 no 800 0.239203970558988 1156 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.708441210259709 0.231679094172 no 801 0.239335654237951 1203 279621
SGTC_982 1491-0518 27.5 µM 0.707814933438039 0.231875147588543 no 802 0.239530095720347 1137 3091256
SGTC_1155 4088-0394 48.2 µM 0.707696526628013 0.23191222474374 no 803 0.239566867423661 1150 2326248
SGTC_1096 rimcazole 32.2 µM 0.707617401827894 0.231937003220563 no 804 0.239591441660999 1120 18528119 A dopamine reuptake inhibitor.
SGTC_1449 4112-4002 201 µM 0.707249480633729 0.232052239643715 no 805 0.239705727102991 1156 2059539
SGTC_467 ro 31-8220 72.8 µM 0.705860401465536 0.232487599690964 no 806 0.240137477579995 1141 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_92 0063-0024 660.874 µM 0.705447549830066 0.232617081627673 no 807 0.240265880866765 1235 3594437
SGTC_1704 st028805 70.8 µM 0.705173632043168 0.23270301210216 no 808 0.240351094204173 1179 2876101
SGTC_3333 9141820 12.094 µM 0.704250193003157 0.232992833192311 no 809 0.240638488980198 1138 1939433
SGTC_803 4488-1585 147 µM 0.703596645695055 0.233198069920198 no 810 0.240842000434542 1163 747204
SGTC_657 3534-0529 86.7 µM 0.702638536886013 0.233499130930527 no 811 0.241140520044227 1195 1049549
SGTC_2636 apigenin dimethyl ether 100 µM 0.701879840453099 0.233737684601364 no 812 0.241377051028567 1193 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_90 0870-0863 4.608 µM 0.696720866031751 0.235363376178298 no 813 0.242988748916851 1196 1738164
SGTC_2409 alverine citrate 63.97 µM 0.69630200099819 0.235495641947295 no 814 0.243119860157346 1220 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1707 st032323 6.317 µM 0.694599154531219 0.236033774912326 no 815 0.243653271125098 1142 3132057 YMR211W DML1
SGTC_617 3770-0098 35 µM 0.693616451376193 0.236344636506164 no 816 0.243961386935721 1155 5962639
SGTC_2349 9023730 187.07 µM 0.691678391541788 0.236958369184679 no 817 0.244569659955235 1192 4126287
SGTC_1295 1013-0063 9.78 µM 0.691427715940114 0.237037815500816 no 818 0.244648395785784 1212 6826038
SGTC_918 glabranin 770.725 nM 0.690390993511163 0.237366538096308 no 819 0.244974169522164 1221 124049 Also referred to as licorice root.
SGTC_491 tetrandrine 80.3 µM 0.690304104520004 0.237394100108383 no 820 0.24500148361903 1191 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_445 e6 berbamine 66 µM 0.689571145318083 0.237626671635121 no 821 0.245231959111449 1247 6610268 A calcium/calmodulin antagonist.
SGTC_1594 piperine 70.1 µM 0.689455562445168 0.237663358052689 no 822 0.245268314226872 1198 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_935 2996-0153 430 µM 0.688497853081293 0.237967457951772 no 823 0.245569660902642 1213 23738523
SGTC_713 1488-1073 324 µM 0.686892340747662 0.238477731877217 no 824 0.246075286936558 1183 3312542
SGTC_2879 9041815 71.43 µM 0.686642106225319 0.238557316895705 no 825 0.246154143884328 1160 4942971
SGTC_481 bay k-8644 50 µM 0.685707275966756 0.238854760482043 no 826 0.246448858818805 1163 2303 A calcium channel antagonist.
SGTC_907 3448-6986 75.5 µM 0.685137532939912 0.239036140324563 no 827 0.246628568910797 1256 590582
SGTC_916 4466-0038 42 nM 0.684912464615015 0.239107812417086 no 828 0.246699579986701 1257 5722064 YGL116W CDC20
SGTC_1367 1812-0510 76.9 µM 0.684683046433016 0.239180881790793 no 829 0.246771974748297 1200 1142582 YDR527W RBA50
SGTC_2709 st078560 56 µM 0.684320181147789 0.239296478791284 no 830 0.24688650304034 1226 17250903
SGTC_2291 7917025 104.35 µM 0.684269990694062 0.239312470229108 no 831 0.246902346494499 1183 2964612
SGTC_397 arbidol 50 µM 0.684073788938741 0.239374988677617 no 832 0.246964286073164 1234 131410 A RNA synthesis inhibitor.
SGTC_2512 diallyl trisulfide 49.23 µM 0.681846228123985 0.240085412031093 no 833 0.247668094804376 1228 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_27 0485-0001 32.618 µM 0.681370585218013 0.240237254909399 no 834 0.247818515172226 1156 2054479
SGTC_2480 5767542 37.17 µM 0.68066705278646 0.240461944502362 no 835 0.248041094176862 1220 2867358
SGTC_1746 st038117 42 µM 0.679936865188874 0.240695268030774 no 836 0.248272218916055 1218 2898218
SGTC_2961 9083290 32.55 µM 0.67930725341854 0.240896552534313 no 837 0.24847160075563 1181 17741490
SGTC_126 0417-1624 672.48 µM 0.679107796524261 0.240960337242809 no 838 0.248534781411679 1317 41912 YDL195W SEC31
SGTC_177 1327-0068 8.361 µM 0.67907432655941 0.24097104156798 no 839 0.248545384312191 1227 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_968 1309-0633 340 µM 0.679058754655493 0.240976021844303 no 840 0.248550317394675 1197 3761976
SGTC_438 sphingosine 6.67 µM 0.678775289392157 0.24106669076315 no 841 0.248640126547201 1118 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1324 1418-0026 34.4 µM 0.676228201307319 0.24188223140206 no 842 0.249447885001574 1252 1372513
SGTC_796 1234-0020 70.7 µM 0.676046557396921 0.241940448272446 no 843 0.249505542991019 1196 46495034
SGTC_2132 5317594 122.667 µM 0.674859854425696 0.242320973525337 no 844 0.249882404227478 1216 794577
SGTC_866 0495-0101 262 µM 0.674490759476595 0.242439392692881 no 845 0.249999679274407 1196 635694
SGTC_3296 9122258 64.045 µM 0.674490759476595 0.242439392692881 no 846 0.249999679274407 1227 4730474
SGTC_2623 humulene 100 µM 0.673271095374111 0.242830928437472 no 847 0.250387419058382 1178 6187145 An anti-inflammatory.
SGTC_887 0885-0007 9.62 µM 0.670666626856663 0.243668157444627 no 848 0.251216463818006 1263 5719458
SGTC_2242 6630449 61.2675 µM 0.668123258582808 0.244487247056808 no 849 0.252027458175778 1235 691249 YDR170C SEC7
SGTC_2112 5488546 200 µM 0.666966600989902 0.24486023776626 no 850 0.25239673370562 1226 600757
SGTC_707 0865-0008 204 µM 0.666605748136503 0.244976665671539 no 851 0.252511998245041 1251 723043
SGTC_589 1227-0070 34.1 µM 0.665279341468785 0.24540488195947 no 852 0.25293592067946 1242 2841384
SGTC_3268 9137683 49.47 µM 0.664477779306277 0.245663852641423 no 853 0.253192283120518 1253 1953228
SGTC_2053 5265679 138 µM 0.663031743176015 0.246131412513881 no 854 0.253655112101941 1222 764595
SGTC_1221 2958-7315 257 µM 0.661882770282621 0.246503260257349 no 855 0.254023177381862 1254 4562705
SGTC_1999 st074831 12.5 µM 0.661546435972936 0.246612166704997 no 856 0.254130972674585 1236 17112523
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.66058859847028 0.246922459625653 no 857 0.254438091417103 1371 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.659527203382283 0.247266544080645 no 858 0.254778641658506 1302 65057 A dermal irritant. YDR527W RBA50
SGTC_1025 k007-0731 70 µM 0.658976354208504 0.247445220086941 no 859 0.25495547647304 1230 6256118
SGTC_1262 0737-0114 49.6 µM 0.658942433522818 0.247456225013478 no 860 0.254966367865023 1286 765919
SGTC_1093 fluphenazine 7.97 µM 0.657001596065922 0.248086328485571 no 861 0.255589945099178 1300 6602611 An atypical antipsychotic.
SGTC_1675 st018485 24.5 µM 0.656943895776268 0.248105074291695 no 862 0.255608495976182 1268 3323024
SGTC_2937 9044753 11.33 µM 0.656369947404178 0.248291581122851 no 863 0.255793060984648 1257 6465530 YGL099W LSG1
SGTC_299 1273-0059 1.44 µM 0.654385854122078 0.248936895629749 no 864 0.256431622861663 1219 2848077
SGTC_1298 1079-1278 263 µM 0.653865500003143 0.24910628532892 no 865 0.256599231350709 1282 2840950
SGTC_1627 st003713 25.6 µM 0.652564440228522 0.249530084540734 no 866 0.257018558310965 1293 16195070 YER133W GLC7
SGTC_1245 0418-0076 17.2 µM 0.651200763640357 0.249974691020043 no 867 0.257458448736808 1276 6790114
SGTC_927 2425-1185 123 µM 0.651047554450853 0.250024668854177 no 868 0.257507894895292 1246 730375
SGTC_818 4072-2707 53.5 µM 0.650960705826203 0.250053001794766 no 869 0.257535926284756 1216 882871
SGTC_3171 9103192 49.47 µM 0.650908677255682 0.250069976079179 no 870 0.257552719861576 1301 13018434
SGTC_1476 4112-3294 3.34 µM 0.649188702555295 0.250631460579111 no 871 0.258108206528368 1307 704369
SGTC_2146 5545642 200 µM 0.648972211104599 0.250702181344009 no 872 0.258178169057731 1283 825326
SGTC_425 3825-7017 13.1 µM 0.647348883140374 0.251232806705086 no 873 0.258703085438743 1346 3397440
SGTC_1982 st072467 71.9 µM 0.646809967654772 0.251409095934211 no 874 0.258877470234692 1253 3163533
SGTC_3191 9110352 49.47 µM 0.643949996731222 0.252345738442367 no 875 0.2598039297463 1284 17122424
SGTC_1401 3807-4679 7.6 µM 0.643691571565401 0.252430463393807 no 876 0.259887728239149 1281 3291456
SGTC_2240 6690706 185.951 µM 0.643599104216167 0.252460782549029 no 877 0.259917715642556 1206 805876
SGTC_1654 st012436 41.8 µM 0.642143966240268 0.252938160918874 no 878 0.260389855624501 1245 4323132
SGTC_1546 5-methoxyflavanone 78.7 µM 0.641265181258379 0.253226688534942 no 879 0.260675203576244 1308 147795
SGTC_2595 hexamethylquercetagetin 100 µM 0.640600049761769 0.253445183252179 no 880 0.26089128361903 1237 386331
SGTC_2034 5197015 53.07 µM 0.638039309078684 0.254287306879375 no 881 0.261724045966207 1331 780676
SGTC_1376 2910-0861 41.3 µM 0.637972116034284 0.254309423677529 no 882 0.261745915741463 1328 1112859
SGTC_479 n-linoleoylglycine 10 µM 0.637239865503855 0.254550511561109 no 883 0.261984307046864 1275 6433346 An anti-infammatory.
SGTC_3150 9097574 49.47 µM 0.63650154450001 0.254793719271769 no 884 0.262224787305245 1280 17217476
SGTC_222 nsc-310342 10.666 µM 0.636067364700703 0.254936797685149 no 885 0.262366257808948 1253 432556
SGTC_1336 1486-0901 104 µM 0.635296655286647 0.255190878656608 no 886 0.262617477306892 1299 5006114
SGTC_2968 9090663 33.37 µM 0.630732972895213 0.256698104093058 no 887 0.264107567885201 1281 25236811
SGTC_2687 chenodiol 100 µM 0.630290412877372 0.256844512396827 no 888 0.264252297178281 1318 5702181 A cholesterol synthesis inhibitor.
SGTC_899 1083-0020 478 µM 0.62894375155547 0.257290283885922 no 889 0.2646929407404 1350 767123
SGTC_2650 prasterone 100 µM 0.628434354728462 0.257459009057979 no 890 0.264859718781159 1266 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3071 9117417 49.47 µM 0.628267019671673 0.257514447220598 no 891 0.264914516430815 1249 45595590 YGL055W OLE1
SGTC_127 0180-0333 59.125 µM 0.62686358021402 0.257979651168958 no 892 0.265374331126282 1268 771601
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.623754914522743 0.259011643685105 no 893 0.266394276417821 1297 97141
SGTC_917 harmaline 728.087 nM 0.62285494832301 0.259310806024836 no 894 0.266689922814429 1328 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1955 wogonin 32.4 µM 0.621014237668412 0.259923241589586 no 895 0.267295127704884 1382 5281703 A flavanone.
SGTC_2975 9084847 53.72 µM 0.620527354630899 0.260085360490868 no 896 0.267455325167379 1343 27211724
SGTC_2537 larixol 68.93 µM 0.620099633972182 0.260227822919818 no 897 0.26759609657644 1289 6708759
SGTC_1774 st048371 48.465 µM 0.618604582799991 0.26072610064443 no 898 0.268088441042822 1277 4242727
SGTC_502 l-744,832 89.3 µM 0.617768366161659 0.261005012825228 no 899 0.268364019372506 1283 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1172 0370-0043 85 µM 0.616778409277757 0.261335401812858 no 900 0.268690447441307 1361 376585
SGTC_3308 9128332 17.569 µM 0.613486487545686 0.262435593184601 no 901 0.269777357355323 1355 17332805 YDL196W YDL196W
SGTC_1405 3909-7894 12 µM 0.612915417637092 0.262626691236222 no 902 0.269966134159742 1362 7104060
SGTC_2891 9063876 19.48 µM 0.612666847573196 0.262709892877011 no 903 0.270048323838543 1292 6472478
SGTC_1397 3532-0190 20.1 µM 0.611713973736575 0.263028964715821 no 904 0.270363507462785 1282 5322280
SGTC_2044 5102272 200 µM 0.611532254731096 0.26308983619252 no 905 0.270423635823183 1303 592666
SGTC_2722 naftopidil 47.16 µM 0.609549524617487 0.263754470317551 no 906 0.27108012833948 1338 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2541 muurolladie-3-one 83.07 µM 0.60792812067372 0.26429861944841 no 907 0.27161757397175 1338 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1452 4194-0072 190 µM 0.607851607458372 0.264324311681058 no 908 0.271642948856584 1414 1343545
SGTC_3305 9127027 53.8275 µM 0.60775035947086 0.264358311512071 no 909 0.271676528608983 1303 41905295
SGTC_2261 9010538 184.68 µM 0.606685109980496 0.264716165137551 no 910 0.272029952818539 1272 6457250
SGTC_3172 9105863 49.47 µM 0.606551306646804 0.264761131647478 no 911 0.272074361709837 1313 2348785
SGTC_1805 st050013 60.3 µM 0.604265159425589 0.265530023465527 no 912 0.272833683009885 1321 4037144
SGTC_1996 st072960 66.8 µM 0.603880643549888 0.265659457523261 no 913 0.272961499364613 1315 1719405
SGTC_2752 diclazuril 33.15 µM 0.602992284637386 0.26595861532016 no 914 0.27325691092525 1363 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.602871365808822 0.26599934832749 no 915 0.273297133063857 1370 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3277 9138724 49.47 µM 0.601962885033823 0.266305482374882 no 916 0.273599421598729 1299 15943418
SGTC_1500 4488-1866 171 µM 0.601330589611847 0.266518654434297 no 917 0.273809909627838 1419 2900003
SGTC_1682 st012968 530 nM 0.600896866900905 0.266664929583811 no 918 0.273954340069586 1296 24207270
SGTC_2516 gossypol 71.55 µM 0.600800897237159 0.266697301314866 no 919 0.27398630322723 1384 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2556 citropten 84.59 µM 0.600739780159104 0.266717917881534 no 920 0.274006659524329 1318 2775 A potential DNA crosslinker.
SGTC_2284 7945075 39.21 µM 0.599960963921604 0.266980705752037 no 921 0.274266125684125 1391 1245402
SGTC_320 4092-0846 5.34 µM 0.5992746351956 0.267212394869151 no 922 0.274494879733647 1366 1359356
SGTC_2424 5537928 59.2 µM 0.597505463915067 0.267810094799862 no 923 0.275084980061831 1354 5382802
SGTC_2487 5918373 44.05 µM 0.59639119157986 0.268186887907012 no 924 0.275456961753524 1370 2876279
SGTC_171 k064-0041 9.68 µM 0.595962232380503 0.268332012280044 no 925 0.275600228740874 1299 53325
SGTC_677 0929-0063 136 µM 0.59591865057152 0.268346758975709 no 926 0.275614786568061 1326 1539583
SGTC_2266 7929956 200 µM 0.593217868800497 0.269261412054904 no 927 0.27651767782098 1336 2967153
SGTC_442 cape 100 µM 0.591735428136524 0.269764122714421 no 928 0.27701388434724 1398 5281787
SGTC_762 1165-0429 115 µM 0.590897125146497 0.270048607652505 no 929 0.277294676177343 1441 5967793
SGTC_1658 st012944 20 µM 0.59084912594355 0.270064901114703 no 930 0.277310757851088 1306 24207260
SGTC_1928 4'-methoxychalcone 40.3 µM 0.589264863326172 0.270602959308927 no 931 0.277841805697065 1469 641818
SGTC_1785 bathophenanthroline 24 µM 0.588725457110307 0.270786278278502 no 932 0.278022728917324 1328 72812 An iron chelator.
SGTC_2367 9070478 135.38 µM 0.588145648241105 0.270983397331837 no 933 0.278217267744979 1374 572802
SGTC_2606 farnesol 9.78 µM 0.587056426836836 0.271353896079245 no 934 0.278582905227176 1408 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2557 derrustone 83.84 µM 0.585069258763771 0.272030481163901 no 935 0.279250574103314 1337 629853 An antioxidant.
SGTC_2393 9031399 185.94 µM 0.58418369358815 0.272332265754231 no 936 0.279548365563847 1427 1526623 YDL150W RPC53
SGTC_618 k072-0232 33.2 µM 0.583275209318967 0.272642033498361 no 937 0.279854024221181 1370 5872756 YGL099W LSG1
SGTC_3319 9138450 16.7555 µM 0.582953981015858 0.272751605205911 no 938 0.2799621399529 1344 2029690
SGTC_2497 7-hydroxyflavone 100 µM 0.581335963472372 0.273303846645247 no 939 0.280507023420337 1395 5281894
SGTC_787 4152-0075 138 µM 0.580874665940586 0.273461392319295 no 940 0.280662463918127 1403 9566539
SGTC_733 4069-0007 56.1 µM 0.580731325593538 0.273510356106776 no 941 0.280710772888141 1405 5717425 YNL287W SEC21
SGTC_1310 1188-0297 994 nM 0.579834620713776 0.273816760966485 no 942 0.281013074151207 1326 1588352
SGTC_2423 st077119 87.2 µM 0.57975483800052 0.273844031011713 no 943 0.281039978484367 1320 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_124 0136-0217 7.121 µM 0.577954496300157 0.274459751697336 no 944 0.281647420530625 1482 3976905
SGTC_2362 9071156 126 µM 0.577124194206727 0.274743946796543 no 945 0.281927780729939 1435 653133
SGTC_1677 st019204 53.9 µM 0.576650451297118 0.274906164103813 no 946 0.282087805202771 1332 3945625
SGTC_2743 auranofin 4.32 µM 0.576135025107028 0.275082708041405 no 947 0.282261959431231 1360 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2763 lisinopril 49.32 µM 0.575711332014933 0.275227873335117 no 948 0.282405157255639 1350 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1041 0206-0046 107 µM 0.573866771736847 0.275860293823214 no 949 0.28302898004785 1396 50494
SGTC_2198 6589944 200 µM 0.573692220614422 0.275920176862873 no 950 0.283088046769168 1357 5290268
SGTC_2669 eugenol 100 µM 0.571876869319839 0.27654334546915 no 951 0.283702697743787 1386 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2333 9017922 200 µM 0.571121588098589 0.276802819346675 no 952 0.283958612888855 1492 3163164
SGTC_2639 lactacystin 53 µM 0.570818478978826 0.276906984808747 no 953 0.28406134769255 1423 3870 A proteasome inhibitor.
SGTC_2583 asiatic acid 100 µM 0.569915922652455 0.277217267908759 no 954 0.284367362402266 1372 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_886 0866-0150 153 µM 0.569748155493331 0.277274962067583 no 955 0.28442426177119 1454 271463
SGTC_1834 st055981 52.8 µM 0.568489625617169 0.277707950407165 no 956 0.284851274071934 1452 471719 YDL150W RPC53
SGTC_943 3253-1379 105 µM 0.56830462032729 0.277771628003988 no 957 0.284914071130844 1446 668464
SGTC_2147 5545932 89.7195 µM 0.56552810016048 0.278728143379871 no 958 0.285857308391648 1383 797404
SGTC_1016 4226-1401 38 µM 0.565337613146912 0.278793825173827 no 959 0.285922074881007 1372 2901613
SGTC_201 4262-0159 12.803 µM 0.565179900036264 0.27884821190387 no 960 0.285975703365943 1379 1341029
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.562429913603166 0.27979736258555 no 961 0.28691157144242 1452 688761
SGTC_156 3474-0145 5.642 µM 0.562325346875441 0.279833484428785 no 962 0.286947185932417 1349 2265471
SGTC_1350 1495-0454 146 µM 0.561564927713318 0.28009623391347 no 963 0.287206240854087 1446 1069057
SGTC_1426 4048-4480 71.7 µM 0.561416815053742 0.280147425550563 no 964 0.287256711841494 1438 14224343
SGTC_3328 9140624 29.0385 µM 0.560980077687814 0.280298399877876 no 965 0.287405559243624 1459 4904392
SGTC_2350 9023895 38.85 µM 0.557207330375289 0.281604226608927 no 966 0.288692890961365 1459 2997209
SGTC_210 3551-0445 56.827 µM 0.555863099364417 0.282070200929413 no 967 0.289152222879323 1448 2865180 YOR207C RET1
SGTC_2788 5282734 71.43 µM 0.555300125072588 0.282265464809585 no 968 0.289344696663435 1521 743706
SGTC_1802 st050112 57.9 µM 0.555168603329688 0.282311091620756 no 969 0.289389670955986 1371 4662563
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.553569932486887 0.282865977384193 no 970 0.289936604109968 1424 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_278 4092-0821 23.9 µM 0.552127643290011 0.283367033348725 no 971 0.290430451906651 1425 877900
SGTC_1603 st002045 67.8 µM 0.551811110412777 0.28347705481934 no 972 0.290538887184894 1395 5887985
SGTC_2331 7980721 200 µM 0.550556777019871 0.28391324108038 no 973 0.29096877277367 1448 2981221
SGTC_2245 6637752 200 µM 0.549596914760519 0.284247243727896 no 974 0.291297937714865 1473 681890
SGTC_2508 celastrol 40.54 µM 0.549096866891881 0.284421319448316 no 975 0.291469487632196 1367 122724 Celastrol is a natural product and antioxidant.
SGTC_2013 4024628 200 µM 0.548679890162574 0.284566515534391 no 976 0.291612574605587 1434 5230760
SGTC_236 1509-0011 5.31 µM 0.548068705472583 0.284779401006816 no 977 0.291822363856369 1443 3107280
SGTC_315 k915-0449 187 µM 0.547873288641517 0.284847483868209 no 978 0.291889455549049 1464 20970215 YNL149C PGA2
SGTC_2440 5628896 157.78 µM 0.547175250706938 0.2850907423817 no 979 0.292129168816096 1453 5522048
SGTC_2899 9053889 58.44 µM 0.546005645969719 0.285498558565221 no 980 0.292531028107914 1408 6470052
SGTC_1525 8-methoxypsoralen 92.5 µM 0.545410514749832 0.285706174661507 no 981 0.292735605166847 1547 4114 Related to psoralen; DNA damaging agent.
SGTC_3225 9130819 49.47 µM 0.544761631942191 0.285932624228632 no 982 0.292958735078977 1462 4547121
SGTC_2164 5685496 200 µM 0.543062037336418 0.286526159227126 no 983 0.293543544708427 1420 759046
SGTC_289 k017-0060 526 µM 0.541850766023381 0.286949517635818 no 984 0.293960657933852 1423 5512909
SGTC_2090 5301565 104.445 µM 0.541397317687709 0.287108081172411 no 985 0.294116877813362 1443 2056344
SGTC_750 4073-0104 132 µM 0.540827121624143 0.287307528361794 no 986 0.294313373506449 1311 22330957
SGTC_1773 st048542 73.5835 µM 0.540481548536865 0.287428437243943 no 987 0.29443249120523 1344 3237138
SGTC_3156 9099931 49.47 µM 0.539945399560918 0.28761607231042 no 988 0.294617343707527 1476 18111053
SGTC_1626 st003712 1.76 µM 0.539790394693249 0.287670329864417 no 989 0.294670795988617 1446 24207035
SGTC_3044 9093193 49.47 µM 0.537014528706106 0.288642805700322 no 990 0.295628789187212 1378 25236277
SGTC_1951 sophoraflavanone G 9.2 µM 0.536809700277356 0.288714625040844 no 991 0.295699535247641 1412 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_495 decylubiquinone 155 µM 0.536714843903299 0.288747887543294 no 992 0.295732300497352 1380 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_504 lovastatin 124 µM 0.535645121849505 0.289123123005546 no 993 0.296101918880582 1391 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2338 7999974 200 µM 0.535067875691593 0.289325703736976 no 994 0.296301461323242 1489 315925
SGTC_2303 7774051 200 µM 0.533589073658949 0.289844983642182 no 995 0.296812934704687 1496 2953184
SGTC_457 grayanotoxin iii 135 µM 0.53342271572758 0.289903427415038 no 996 0.296870498215623 1394 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3086 9117350 49.47 µM 0.531733154403761 0.290497305835157 no 997 0.297455412875272 1375 2679265
SGTC_231 b-estradiol 524 µM 0.531690689708547 0.290512239448025 no 998 0.297470120642139 1378 450 A steroid.
SGTC_986 1493-0483 84 µM 0.530728082813423 0.290850856968018 no 999 0.297803611300123 1411 40079
SGTC_1997 st073024 93.8 µM 0.528252773530603 0.291722445960267 no 1000 0.298661952643315 1418 686268
SGTC_2287 7945887 168.79 µM 0.524611519442691 0.29300678711113 no 1001 0.29992663857623 1479 1245853
SGTC_653 0203-0016 55.2 µM 0.524436780452333 0.293068486865017 no 1002 0.299987390093092 1485 295302
SGTC_412 gemfibrozil 100 µM 0.523046874454067 0.293559472505317 no 1003 0.300470816964059 1429 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.522185625496156 0.293863900537429 no 1004 0.300770546698769 1412 61125 An anti-inflammatory.
SGTC_423 5-fluorouracil 457 µM 0.521750717216931 0.294017684228272 no 1005 0.300921953646765 1376 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2276 7947513 42.08 µM 0.521713995879667 0.294030670606678 no 1006 0.300934739215903 1300 2105100
SGTC_2885 9057732 51.95 µM 0.519850816669998 0.294689925464323 no 1007 0.301583778836902 1437 6471414
SGTC_60 0986-0278 202 µM 0.518735025417421 0.295085055662373 no 1008 0.301972766619441 1280 3110598
SGTC_2011 4012611 177 µM 0.517548203824393 0.295505607117072 no 1009 0.302386764204261 1425 2049887
SGTC_1145 3546-0597 10.2 µM 0.515150603443521 0.296356039030586 no 1010 0.30322389189181 1453 875334
SGTC_1178 0988-0033 191 µM 0.512935417490222 0.297142764131921 no 1011 0.30399824876116 1482 5392207
SGTC_1170 0310-0127 64.8 µM 0.512865899915819 0.297167468800715 no 1012 0.304022564103266 1504 774975
SGTC_843 0310-0051 143 µM 0.51186581892576 0.297522974446494 no 1013 0.304372460924614 1469 2065037
SGTC_2267 7931562 200 µM 0.511441028402976 0.297674036377367 no 1014 0.304521135968105 1361 934880
SGTC_2957 9076800 11.52 µM 0.511238565337021 0.297746047617521 no 1015 0.304592008628498 1427 16459615
SGTC_36 0335-0881 14.2 µM 0.511203148238978 0.297758645443602 no 1016 0.304604407218835 1474 23828853
SGTC_2655 perillic acid 100 µM 0.510596342735375 0.29797452330921 no 1017 0.304816868655589 1424 5702197 An apoptosis inducer.
SGTC_2458 5808907 16.39 µM 0.510349295441053 0.298062433586095 no 1018 0.304903386441364 1479 2731747
SGTC_3223 9129970 49.47 µM 0.50937016759407 0.298410966455211 no 1019 0.3052463914974 1522 17248386
SGTC_782 0083-0095 30.5 µM 0.508451074369596 0.298738297906854 no 1020 0.305568521110291 1463 3591729 An indicator and reagent.
SGTC_2757 clomiphene 4.22 µM 0.507128916039304 0.299209465459469 no 1021 0.306032183580255 1596 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1010 4112-3296 15.2 µM 0.506878275841331 0.29929882221681 no 1022 0.306120114682449 1576 704384
SGTC_3219 9131112 49.47 µM 0.506439211615168 0.299455383961131 no 1023 0.30627417676012 1438 17612988 YMR079W SEC14
SGTC_790 1575-0012 79.1 µM 0.505630590776011 0.299743819504182 no 1024 0.306558001210532 1512 378741 YLR208W SEC13
SGTC_1916 st067606 49.2 µM 0.504818604797487 0.300033581937452 no 1025 0.306843123613287 1574 19590279
SGTC_82 0054-0107 293.755 µM 0.504321046669321 0.300211201359666 no 1026 0.307017894953973 1551 3104697
SGTC_1671 st016596 74.5 µM 0.503660374516863 0.300447123037395 no 1027 0.307250029203173 1467 2829167
SGTC_3222 9128301 49.47 µM 0.503259694797418 0.300590243913974 no 1028 0.30739084996121 1467 4911358
SGTC_1941 st076221 61.8 µM 0.502754724127226 0.300770660846863 no 1029 0.307568364707159 1469 2828568
SGTC_2582 agaric acid 100 µM 0.502198139522582 0.300969575094335 no 1030 0.307764075762475 1361 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2315 7733312 200 µM 0.49980716072465 0.301824745692433 no 1031 0.308605434021223 1453 726316
SGTC_626 0214-0009 33 µM 0.499792549428847 0.301829975004523 no 1032 0.308610578666562 1577 3437874
SGTC_1602 st001878 87.6 µM 0.499754407694929 0.301843625938471 no 1033 0.308624008569227 1505 595405 YLR310C CDC25
SGTC_1759 st043059 70 µM 0.499306741225757 0.302003866589049 no 1034 0.308781653389535 1444 669426
SGTC_1632 st005650 90 µM 0.498642941754655 0.302241541595814 no 1035 0.30901547386202 1490 2759605
SGTC_606 k015-0008 38.6 µM 0.495487502511076 0.303372500230873 no 1036 0.310128020821156 1604 1970475
SGTC_931 2812-0076 566 µM 0.49521198081155 0.303471341216223 no 1037 0.310225247210583 1480 3450959
SGTC_1804 st050076 49.1 µM 0.495114290808587 0.30350639009929 no 1038 0.310259723348528 1513 3895976
SGTC_1857 st056007 79.3 µM 0.493177052087971 0.304201798992512 no 1039 0.310943745481031 1487 619834
SGTC_1000 4048-0884 8.67 µM 0.492031812611124 0.304613238153533 no 1040 0.311348427210997 1527 13040088
SGTC_1342 1486-1464 234 µM 0.490794249128706 0.305058123699272 no 1041 0.311785988955874 1492 3253938
SGTC_2857 9024691 58.44 µM 0.489968458770605 0.305355143364323 no 1042 0.312078109180767 1511 16478292
SGTC_3042 9091578 49.47 µM 0.48948503382915 0.305529080791824 no 1043 0.312249173800656 1480 25236497
SGTC_3170 9103054 49.47 µM 0.489095402798902 0.305669302903829 no 1044 0.312387077997477 1430 16432970
SGTC_1689 st020265 53.493 µM 0.486186285353981 0.306717148493893 no 1045 0.313417547115835 1582 5758320 YPR016C TIF6
SGTC_1056 3448-1962 115 µM 0.485053150492684 0.307125724951347 no 1046 0.313819321804248 1533 715507
SGTC_3241 9133421 49.47 µM 0.484803137485282 0.307215904866833 no 1047 0.313907998467615 1524 17018221
SGTC_1771 st048882 4.1505 µM 0.484404825876534 0.307359600304082 no 1048 0.314049297096732 1434 4580403
SGTC_2504 purpurogallin 52.29 µM 0.484243247401276 0.307417900007992 no 1049 0.314106623856094 1491 5281571 An antioxidant.
SGTC_1854 st056233 32.9 µM 0.482495374221223 0.308048867109856 no 1050 0.314727041844698 1578 5393174
SGTC_1062 mesoridazine 14.2 µM 0.481169605060489 0.308527837122068 no 1051 0.315197980671033 1515 4078 A neuroleptic.
SGTC_139 0099-0334 718.624 µM 0.480796625664674 0.308662644825607 no 1052 0.315330524352523 1522 97690
SGTC_41 0478-0632 82.643 µM 0.478770327760343 0.309395469527059 no 1053 0.316051013935632 1558 3750424
SGTC_2654 protoveratrine a 100 µM 0.478517737325799 0.309486873852428 no 1054 0.316140876438031 1502 5702278 A heart drug and vasodilator.
SGTC_3108 9121785 49.47 µM 0.478119441251439 0.3096310282912 no 1055 0.316282597781461 1608 17140271
SGTC_523 1934-0222 13.7 µM 0.476376883846853 0.31026205247965 no 1056 0.316902950086546 1483 1361595
SGTC_1935 st074532 41.6 µM 0.476253693699335 0.310306683931534 no 1057 0.316946825425869 1652 2829742
SGTC_125 0133-0007 11.75 µM 0.476243968191792 0.310310207575181 no 1058 0.316950289367256 1659 26541
SGTC_1230 0170-0365 3.77 µM 0.476226338109974 0.31031659516547 no 1059 0.316956568727752 1576 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1547 harmine 94.2 µM 0.475474323985221 0.310589112163079 no 1060 0.317224464979838 1515 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1384 3089-0840 101 µM 0.475390643543057 0.310619442948845 no 1061 0.317254281086143 1609 1069836
SGTC_1652 st011932 78 µM 0.475105385947215 0.310722846997066 no 1062 0.31735592988703 1586 1551076
SGTC_2446 5162541 200 µM 0.474498824684343 0.310942771257062 no 1063 0.317572117945315 1469 1549321
SGTC_1872 amphotericin b 148 nM 0.473690483712805 0.311235960873228 no 1064 0.31786032020929 1581 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_720 r052-1644 49.9 µM 0.472791058738599 0.311562327955758 no 1065 0.318181126879578 1498 1422863 YOR257W CDC31
SGTC_1270 0831-1170 17.3 µM 0.471043374722626 0.312196919282436 no 1066 0.318804880348924 1491 6764716
SGTC_991 3996-0057 64.7 µM 0.469888707454521 0.312616489803544 no 1067 0.319217266338028 1542 715343
SGTC_1696 st025591 34.7925 µM 0.469748079724047 0.312667606197029 no 1068 0.31926750641198 1536 2787147
SGTC_2134 5324836 1.464 µM 0.469620219781951 0.312714084789138 no 1069 0.319313187999988 1575 699272
SGTC_2448 5185112 27.17 µM 0.468798310056122 0.313012929713813 no 1070 0.319606904008815 1506 5718189
SGTC_2453 5731132 22.18 µM 0.468490111583489 0.313125021825677 no 1071 0.319717070384866 1646 1362040
SGTC_34 0469-0683 81.75 µM 0.468181752543787 0.313237189621724 no 1072 0.319827310076324 1591 3690923
SGTC_1359 1582-0056 520 nM 0.466634771528925 0.313800175632504 no 1073 0.320380602537951 1576 3661189
SGTC_1092 toremifene 6.32 µM 0.466623829014415 0.313804159440394 no 1074 0.320384517656583 1529 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1437 4092-1038 11.6 µM 0.463465670455101 0.314954846291986 no 1075 0.32151530816692 1489 3977136
SGTC_2239 6685329 187.64 µM 0.46159039000995 0.315638963548502 no 1076 0.32218754369021 1517 805680
SGTC_333 3486-0131 40.1 µM 0.461485815353834 0.315677131848958 no 1077 0.32222504792991 1651 6744690
SGTC_985 1493-0307 8.71 µM 0.460819155321304 0.315920499725813 no 1078 0.322464178773409 1634 3278274
SGTC_1386 3228-0095 33.8 µM 0.458836326828411 0.316644813441111 no 1079 0.323175852956 1630 870181
SGTC_2995 9067767 71.4286 µM 0.458101302862114 0.316913491588237 no 1080 0.323439831473786 1565 11673567
SGTC_488 nitrendipine 139 µM 0.457686580867738 0.317065130277323 no 1081 0.323588815103589 1587 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1840 st055363 71 µM 0.455447424453304 0.31788438429041 no 1082 0.324393691773573 1481 676033
SGTC_1098 clofazimine 15.1 µM 0.454470999001779 0.318241914720805 no 1083 0.324744930420428 1591 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_319 1348-1596 45.5 µM 0.45418513210852 0.318346620542347 no 1084 0.32484779164678 1659 5380505
SGTC_153 4077-0274 519.67 µM 0.453012539130817 0.31877626351946 no 1085 0.325269856197155 1669 3121976
SGTC_1391 3442-0225 151 µM 0.452676930803859 0.318899276696181 no 1086 0.325390696767036 1549 5227075
SGTC_2451 5856223 45.7 µM 0.450493652044238 0.319700017746372 no 1087 0.326177265189635 1500 2179896
SGTC_1800 st050079 29.0735 µM 0.448925589421959 0.320275640914559 no 1088 0.326742667850473 1529 3645560
SGTC_1643 st009866 20.2 µM 0.448782609303095 0.320328149314081 no 1089 0.326794242592473 1609 3156273 YOR207C RET1
SGTC_1381 2324-0066 62.1 µM 0.446379101554718 0.32121135772979 no 1090 0.327661713065476 1591 10885928
SGTC_1938 st074717 56.4 µM 0.446271375803588 0.32125096706284 no 1091 0.327700615117995 1497 17250979
SGTC_1361 1608-0041 5.61 µM 0.445433009769346 0.321559292616659 no 1092 0.328003430752876 1535 X1361
SGTC_2150 5556613 200 µM 0.444964500296626 0.321731649738876 no 1093 0.328172704433057 1586 743190
SGTC_2247 cerulenin 830 nM 0.444909944509882 0.321751722432886 no 1094 0.328192417874086 1627 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2664 lyso-paf C-16 73.48 µM 0.444550419703832 0.321884015294441 no 1095 0.328322342199836 1565 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2203 7227154 166.4 µM 0.44056467673283 0.323352142255874 no 1096 0.329764089930568 1563 896304
SGTC_2244 6635614 200 µM 0.438533380470657 0.324101420629376 no 1097 0.330499838965076 1556 836499
SGTC_2895 9054447 58.44 µM 0.435564607058671 0.325197785642462 no 1098 0.331576327226254 1580 2697450
SGTC_1064 honokiol 6.76 µM 0.435529501707667 0.325210759094157 no 1099 0.331589064904823 1572 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1036 k216-0215 33.5 µM 0.434152823931467 0.325719687858405 no 1100 0.332088734190758 1546 622330
SGTC_1618 st003135 44.5 µM 0.432440707497351 0.32635307459296 no 1101 0.332710568634049 1569 1270615
SGTC_578 3460-0051 92 µM 0.431437807913893 0.326724323856355 no 1102 0.333075032108183 1659 2876744
SGTC_1031 k035-0009 16 µM 0.430867744643352 0.326935424074358 no 1103 0.333282268981203 1709 5180959
SGTC_737 1950-0117 57.9 µM 0.428733746551827 0.327726156617231 no 1104 0.334058499478894 1653 5393513
SGTC_2700 st077718 96.8 µM 0.427938365018763 0.328021075604865 no 1105 0.334347997213638 1565 904970
SGTC_1271 0832-2808 169 µM 0.427692997353489 0.328112076974372 no 1106 0.334437324419327 1694 3663794
SGTC_3260 9137109 49.47 µM 0.427572581091922 0.328156740400565 no 1107 0.33448116593223 1659 17478346
SGTC_1121 fusaric acid 630.51 nM 0.426532690561964 0.328542546899328 no 1108 0.33485986625227 1567 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2271 7849410 118.62 µM 0.425967875604689 0.328752173773492 no 1109 0.335065627184615 1703 972430
SGTC_3102 9121669 49.47 µM 0.424302203684723 0.329370689137266 no 1110 0.335672716150992 1624 41905072
SGTC_2644 guaiazulene 100 µM 0.423886858628221 0.329524992408455 no 1111 0.335824164253935 1649 3515 A coloring agent.
SGTC_53 0973-0023 39.979 µM 0.423375562543324 0.329714981945996 no 1112 0.336010635789192 1702 674768
SGTC_1028 k015-0029 4.8 µM 0.422617679497098 0.329996680142288 no 1113 0.336287112740185 1565 4588309
SGTC_408 cantharidin 100 µM 0.421519291005707 0.330405112209094 no 1114 0.336687963785065 1617 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3047 9092122 49.47 µM 0.421174543338145 0.330533347165374 no 1115 0.336813815909418 1559 17173831
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.421026560665978 0.330588398026816 no 1116 0.336867843443961 1633 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3226 9131256 49.47 µM 0.420737852440975 0.330695810587477 no 1117 0.336973258674095 1534 17178073
SGTC_2695 st077686 51.995 µM 0.419221924688197 0.33126003314686 no 1118 0.337526975129912 1550 2876092
SGTC_1383 3049-0032 20.7 µM 0.418651949075387 0.331472275126413 no 1119 0.337735258800706 1708 712864
SGTC_2638 epoxomicin 18 µM 0.417045591942355 0.332070725850207 no 1120 0.338322530060146 1696 9915668 A protesome inhibitor.
SGTC_1353 1498-1206 8.11 µM 0.415283191724907 0.332727803722616 no 1121 0.338967302132498 1583 6756808
SGTC_1757 st041620 31.8375 µM 0.413120731774498 0.333534738728759 no 1122 0.339759080403225 1583 5289815
SGTC_2922 7999257 32.47 µM 0.412772209653241 0.333664864087234 no 1123 0.339886757037481 1563 2988377
SGTC_906 1165-0455 526 µM 0.411432206938511 0.334165358142037 no 1124 0.340377820911263 1568 3252859
SGTC_2517 totarol 10 µM 0.410636759262101 0.334462599261428 no 1125 0.340669452651536 1548 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1314 1222-0010 41.1 µM 0.409639915898008 0.334835244012936 no 1126 0.341035055764702 1630 3526027
SGTC_2838 9002687 71.43 µM 0.409191789354688 0.335002817851857 no 1127 0.341199459704154 1558 6457060
SGTC_1820 st053765 18.6 µM 0.408843740851539 0.335132990864217 no 1128 0.34132716887084 1576 3690829
SGTC_1247 0448-0043 5.84 µM 0.408406560231147 0.335296528083174 no 1129 0.341487608965678 1618 3089013 YGL099W LSG1
SGTC_1527 coumarin 137 µM 0.406956174195797 0.335839300959971 no 1130 0.342020088453534 1668 323 A hepatotoxic, DNA x-linker.
SGTC_421 streptovitacin 30 mM 0.404151546408915 0.336889837946137 no 1131 0.343050640947173 1616 91467 include heat shock
SGTC_2558 carylophyllene oxide 100 µM 0.404065336419894 0.336922150072889 no 1132 0.343082337112413 1658 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2182 6325192 200 µM 0.403909068609093 0.336980723445263 no 1133 0.343139793713969 1625 736248
SGTC_3084 9116877 49.47 µM 0.403247009318234 0.337228924886697 no 1134 0.343383260115083 1712 27241325
SGTC_936 3005-4620 401 µM 0.402697899090831 0.337434836271316 no 1135 0.343585239827084 1730 777207
SGTC_801 0866-0028 10.1 µM 0.400893350810864 0.338111868266898 no 1136 0.344249322779455 1644 6849771
SGTC_3275 9138069 49.47 µM 0.400606698394949 0.338219463045824 no 1137 0.344354856608949 1669 17617007
SGTC_940 3232-1287 54.8 µM 0.39783078562067 0.339262082315094 no 1138 0.34537746132522 1669 1585493 YIL048W NEO1
SGTC_3101 9120531 49.47 µM 0.397127808389026 0.339526312928504 no 1139 0.3456366071822 1715 24824904
SGTC_1611 st001856 99.4 µM 0.3966079427027 0.339721767496678 no 1140 0.345828297259034 1585 647478
SGTC_2488 5268135 45.7 µM 0.39430407547522 0.340588473584422 no 1141 0.346678277366181 1697 1270356 YLR208W SEC13
SGTC_1902 st060212 70.5 µM 0.394286606086466 0.340595048725765 no 1142 0.346684725412535 1603 688944
SGTC_2008 4012253 172 µM 0.394195982282767 0.340629158556849 no 1143 0.346718175863894 1607 603940
SGTC_812 4251-0442 148 µM 0.393612007422104 0.340848991702751 no 1144 0.346933757403345 1686 5723007
SGTC_2726 cimetidine 79.27 µM 0.392733756086752 0.341179704876097 no 1145 0.347258068034219 1656 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3214 9129694 49.47 µM 0.392626247596527 0.341220196520971 no 1146 0.347297775232881 1747 17158655
SGTC_3312 9133330 71.43 µM 0.38868484411978 0.342705932619098 no 1147 0.348754647584272 1718 17617324
SGTC_3027 9089541 49.47 µM 0.386897190348199 0.343380604191732 no 1148 0.349416160636135 1629 9943819
SGTC_774 k060-0086 136 µM 0.386375538637101 0.343577572988632 no 1149 0.34960928179596 1823 5911235
SGTC_2256 7954252 200 µM 0.386192823961092 0.343646573685351 no 1150 0.349676933971974 1630 2972920
SGTC_590 k048-0076 22.4 µM 0.38594159209683 0.343741457841494 no 1151 0.349769963206614 1729 6832814
SGTC_706 4262-0057 46.9 µM 0.384683767383858 0.344216655516862 no 1152 0.350235861599703 1603 883298
SGTC_586 0957-0265 8.15 µM 0.384163810269861 0.344413163729987 no 1153 0.350428519671234 1695 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1640 st009078 66.4 µM 0.382793420024415 0.344931278605153 no 1154 0.350936470325133 1723 690618
SGTC_3134 9127454 49.47 µM 0.3825301658377 0.345030842650424 no 1155 0.351034079012101 1686 24262820
SGTC_1644 st010134 20.9 µM 0.382153012583911 0.345173502586684 no 1156 0.351173936020193 1734 3818134
SGTC_2457 5731572 11.68 µM 0.381250720479758 0.345514887946843 no 1157 0.351508608234654 1774 2865357
SGTC_76 0433-0009 400.328 µM 0.381058986382793 0.345587447411914 no 1158 0.35157973981846 1646 2841569
SGTC_2253 7938677 135.83 µM 0.381020605983776 0.345601972694335 no 1159 0.351593979217326 1777 2301972
SGTC_773 4358-1457 44.6 µM 0.377134909625116 0.347073710026821 no 1160 0.353036674611577 1802 1186886
SGTC_2155 5570423 76 µM 0.377090752291984 0.347090448269463 no 1161 0.353053081699505 1657 797402
SGTC_562 3772-2733 112 µM 0.376571047341725 0.347287469612944 no 1162 0.353246203666144 1743 2876874 YIL048W NEO1
SGTC_2843 9000894 45.46 µM 0.375614113592223 0.347650353337841 no 1163 0.353601898367081 1623 2242070
SGTC_2148 5546263 113.568 µM 0.375431677808604 0.347719551599543 no 1164 0.353669724732072 1675 792097
SGTC_551 k048-0028 34.9 µM 0.373787904843722 0.348343266558362 no 1165 0.354281059425528 1751 6836383
SGTC_1349 flufenamic acid 69 µM 0.373339635809505 0.348513429515706 no 1166 0.354447840177817 1649 3371 A non-steroidal anti-inflammatory.
SGTC_1905 st060207 84.5 µM 0.373025049563195 0.348632864685015 no 1167 0.354564900245781 1660 1948547
SGTC_2135 5326629 150.42 µM 0.372300112325038 0.348908149982639 no 1168 0.354834707500151 1630 5020077
SGTC_1150 3909-7983 10.9 µM 0.370032234908673 0.349769859459084 no 1169 0.35567923621002 1636 23965914
SGTC_380 3970-0968 6 µM 0.369880867406712 0.349827401126001 no 1170 0.355735628824944 1653 2891601
SGTC_2414 st077232 92.9 µM 0.369816124914818 0.349852013742896 no 1171 0.355759749883312 1583 729801
SGTC_1006 4099-6547 255 µM 0.369283246533143 0.350054617663577 no 1172 0.355958305886572 1706 3146833
SGTC_1692 fluoroquinolonic acid 71 µM 0.369235053706834 0.350072943003978 no 1173 0.355976264960257 1710 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1465 k213-0056 144 µM 0.368985571700483 0.350167814212323 no 1174 0.356069239626201 1656 24048857 YMR208W ERG12
SGTC_416 estradiol valerate 100 µM 0.366799054785843 0.350999686550252 no 1175 0.356884456372488 1693 13791 A steroid.
SGTC_194 1486-1323 56.904 µM 0.365948454924644 0.351323495226999 no 1176 0.357201769286106 1641 5178754
SGTC_876 0720-0963 56.8 µM 0.365704397910824 0.35141642345719 no 1177 0.357292832036962 1822 765861
SGTC_2997 9067075 71.4286 µM 0.36495928183904 0.351700192088878 no 1178 0.35757090061794 1736 27209819
SGTC_381 3461-2219 42.7 µM 0.36273833414252 0.352546503487144 no 1179 0.35840018039453 1790 2883159
SGTC_581 0958-0271 211 µM 0.36176181592991 0.352918845668623 no 1180 0.358765014328598 1628 4591145
SGTC_3261 9137475 49.47 µM 0.361103414743295 0.35316997075073 no 1181 0.359011070324343 1692 17027690
SGTC_259 usnic acid 108.925 µM 0.358823452928359 0.354040079412696 no 1182 0.359863583287756 1747 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1590 st077108 57.8 µM 0.358564306984677 0.354139026414086 no 1183 0.359960526193702 1819 5489485
SGTC_2919 7978188 46.38 µM 0.357923826949111 0.354383616487412 no 1184 0.36020015953173 1822 2980291
SGTC_1285 0929-0069 65.5 µM 0.356738296705986 0.354836511800119 no 1185 0.360643866377849 1706 1206237
SGTC_2858 9025781 8.96 µM 0.355689483670379 0.355237349637337 no 1186 0.361036560746121 1758 4894980 YPL153C RAD53
SGTC_1043 0916-0009 19.3 µM 0.355580604499146 0.355278970522899 no 1187 0.361077335457521 1875 3101130
SGTC_411 enrofloxacin 100 µM 0.355259056156819 0.355401897834653 no 1188 0.361197762935885 1853 71188 A bacterial gyrase inhibitor.
SGTC_748 act1.228 77.9 µM 0.354516460822512 0.355685848076566 no 1189 0.361475935052036 1618 4421505 YNR035C ARC35
SGTC_1063 disulfiram 1.84 µM 0.352573868014643 0.356429026406684 no 1190 0.362203965663633 1701 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2035 5154463 94.595 µM 0.352284062322942 0.356539944291176 no 1191 0.362312619720599 1787 2769623
SGTC_78 0336-0123 156.75 µM 0.351537842699909 0.356825602177825 no 1192 0.362592443695649 1643 6765896
SGTC_1768 st044301 37.178 µM 0.351456100722717 0.356856898439016 no 1193 0.362623100482625 1645 3931349
SGTC_3352 9151559 45.5865 µM 0.350475390418253 0.35723245458498 no 1194 0.362990978005306 1660 17159339
SGTC_2727 riluzole 51.77 µM 0.350442027378936 0.357245233162601 no 1195 0.36300349515267 1739 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2051 5263410 176 µM 0.350174359509816 0.357347760031035 no 1196 0.36310392409808 1749 227584
SGTC_2048 5246248 200 µM 0.348591302031795 0.357954340974836 no 1197 0.36369807929688 1812 677046
SGTC_1930 st074634 34.3 µM 0.347657854735278 0.358312178720261 no 1198 0.364048575746625 1624 684253 YOR116C RPO31
SGTC_1736 st036774 51 µM 0.347510975047446 0.358368496504436 no 1199 0.364103737387763 1888 1272247
SGTC_2925 9010536 32.5 µM 0.347239238189355 0.358472696144833 no 1200 0.36420579738987 1779 2994177
SGTC_1251 0490-5699 265 µM 0.347172842478625 0.358498157705817 no 1201 0.364230736017363 1848 3883818
SGTC_506 n9-isopropylolomoucine 153 µM 0.345983522364033 0.358954347034332 no 1202 0.364677549073065 1877 6610355
SGTC_1946 st076057 65.1 µM 0.344823784652329 0.359399383198847 no 1203 0.365113425475909 1682 953009
SGTC_3140 9094243 49.47 µM 0.34239514562466 0.360331963345464 no 1204 0.366026770605555 1836 19291112
SGTC_2046 4110841 106 µM 0.339917983364656 0.361284032845137 no 1205 0.366959146705624 1826 44119630 YMR134W ERG29
SGTC_862 0452-0056 10.2 µM 0.338853628686115 0.361693370042361 no 1206 0.367359999402842 1750 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_820 1582-0060 59.9 µM 0.33484794603059 0.36323531999183 no 1207 0.368869895236983 1700 3848840
SGTC_3053 9095903 49.47 µM 0.33333321221651 0.36381898216521 no 1208 0.369441385889222 1785 17174018
SGTC_151 3013-0144 2.285 µM 0.331762913080108 0.364424388699055 no 1209 0.370034145347464 1825 906558 YHR107C CDC12
SGTC_1175 0741-0056 27.6 µM 0.331364864659163 0.364577904430933 no 1210 0.370184450535385 1824 765927
SGTC_2762 leflunomide 42.06 µM 0.330239803100834 0.365011925429488 no 1211 0.370609386871119 1743 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1272 0839-0021 27 µM 0.32957727744856 0.365267592458154 no 1212 0.370859697060317 1757 5027250
SGTC_74 000s-0487 160.283 µM 0.329014784604769 0.365484704086314 no 1213 0.371072256556 1808 677548
SGTC_1346 1488-2224 62.4 µM 0.328398716096027 0.365722544371598 no 1214 0.371305106810328 1863 3722427
SGTC_192 3455-0609 60.9 µM 0.327571187424471 0.366042102503636 no 1215 0.371617955023851 1759 3769639
SGTC_145 3737-0113 38.366 µM 0.327278277734353 0.366155234672296 no 1216 0.371728710219652 1871 6849351
SGTC_2395 5646831 180.19 µM 0.326728589656614 0.366367575213343 no 1217 0.371936587273712 1794 6808628
SGTC_2981 9013952 38.96 µM 0.326559845143038 0.366432768214058 no 1218 0.37200040934404 1626 2996344
SGTC_3129 9127257 49.47 µM 0.32642231392267 0.366485905076765 no 1219 0.372052428612754 1609 837894
SGTC_2495 cafestol 54.53 µM 0.326051258177746 0.36662927975036 no 1220 0.372192786928142 1789 16667697 An anti-infammatory.
SGTC_2829 7992743 58.44 µM 0.325548682695482 0.366823502875461 no 1221 0.372382921955324 1924 16462845
SGTC_1467 k284-1082 293 µM 0.324581970419386 0.367197190116072 no 1222 0.372748737272097 1850 3334705
SGTC_2214 7179297 48.276 µM 0.324323081401888 0.367297286276516 no 1223 0.372846723428697 1806 769744
SGTC_579 4491-1009 110 µM 0.3240821973114 0.367390429159785 no 1224 0.372937902341804 1924 1271041
SGTC_3147 9097027 49.47 µM 0.323544069894106 0.367598535585337 no 1225 0.373141618847724 1805 25236841
SGTC_3021 9087658 49.47 µM 0.323179021738267 0.36773973036263 no 1226 0.373279833702883 1829 25237042
SGTC_1829 berberine 14.4 µM 0.322514263788415 0.367996893990562 no 1227 0.373531566818714 1870 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1616 st002734 56.1 µM 0.321230105690417 0.368493841917124 no 1228 0.374018009540542 1778 4026101
SGTC_3289 9119912 71.43 µM 0.321139370649035 0.368528963208756 no 1229 0.374052387831032 1774 17014829
SGTC_263 alizarin 107.927 µM 0.320496100940701 0.368777988491966 no 1230 0.374296142808709 1771 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_524 r073-0010 27.8 µM 0.319601113856035 0.36912455132139 no 1231 0.37463536494732 1711 2772106
SGTC_3247 9135149 49.47 µM 0.319500738182065 0.369163426096513 no 1232 0.37467341585565 1760 8934436 YOR116C RPO31
SGTC_621 3584-0052 32.1 µM 0.319225923264885 0.369269866779535 no 1233 0.374777600300667 1853 2273927
SGTC_1003 4049-0218 100 µM 0.31865182969225 0.369492255715931 no 1234 0.374995273064686 1818 295161
SGTC_856 0433-0016 11.3 µM 0.318512480435301 0.369546242587609 no 1235 0.375048114603055 1748 3911780
SGTC_2938 9059746 27.26 µM 0.318310828305986 0.369624371473639 no 1236 0.375124585677322 1767 6471769
SGTC_66 0109-0187 42.4 µM 0.317924949783962 0.36977389275489 no 1237 0.375270933271724 1649 759417
SGTC_1578 josamycin 24.2 µM 0.316348721780944 0.370384858235363 no 1238 0.375868916925827 1691 5282165 A P450 substrate.
SGTC_94 0334-0113 514.748 µM 0.315130611194004 0.37085723714184 no 1239 0.376331243670501 1680 6795178
SGTC_1425 4048-4433 7.33 µM 0.314935795761612 0.370932803944305 no 1240 0.37640520120834 1845 23734946
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.314170025907493 0.37122988601499 no 1241 0.376695953406295 1764 364106
SGTC_2388 9080168 200 µM 0.31263336901133 0.371826266742111 no 1242 0.377279611616584 1679 15943073
SGTC_2657 nystatin 74.44 µM 0.312491957071669 0.37188116458341 no 1243 0.37733333728832 1810 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_605 1315-0399 119 µM 0.311595447223847 0.372229261214812 no 1244 0.377673997344814 1811 24020461
SGTC_1964 st076914 61 µM 0.310431364076203 0.372681406946584 no 1245 0.378116473158656 1777 24208661
SGTC_279 1273-0055 2.93 µM 0.310029286777828 0.372837620046965 no 1246 0.378269342623756 1888 2847562
SGTC_1054 3429-0080 167 µM 0.309486021502774 0.373048720022506 no 1247 0.378475921909734 1834 1162877
SGTC_1001 4048-4355 44.4 µM 0.308866215914286 0.373289608298101 no 1248 0.378711648443528 1736 21824233
SGTC_305 1682-2595 20.8 µM 0.308781583430441 0.373322504672292 no 1249 0.37874383965658 1799 226033
SGTC_701 4424-0219 185 µM 0.308467060493277 0.373444766816103 no 1250 0.378863480464021 1900 2911779
SGTC_2365 9042475 200 µM 0.306912544858174 0.374049228906554 no 1251 0.379454970096475 1747 6464479
SGTC_1888 azatryptophan 97.5 µM 0.306480497290322 0.374217282543387 no 1252 0.379619413387388 1748 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3046 9092212 49.47 µM 0.306149929210123 0.374345879825393 no 1253 0.379745246885226 1767 25236637
SGTC_169 k015-0017 16.025 µM 0.303025788968949 0.375561918492147 no 1254 0.380935104131015 1857 1840002
SGTC_1444 4112-3581 28 µM 0.301836103039996 0.376025317162536 no 1255 0.381388503706004 1796 2877249
SGTC_2373 9071805 200 µM 0.301787350438675 0.376044310775047 no 1256 0.381407087220383 1939 10149009
SGTC_613 3914-0030 117 µM 0.301348720134127 0.376215211032818 no 1257 0.381574296591589 1800 1145395
SGTC_46 0329-0187a 2.197 µM 0.299125888195657 0.377081649041194 no 1258 0.382421997075064 1833 46494817
SGTC_1600 coumarin 106 71.1 µM 0.296229149681169 0.378211698036247 no 1259 0.383527544533112 1825 100336 A hepatotoxic, DNA x-linker.
SGTC_2793 7325131 81.82 µM 0.294948821190476 0.378711500855719 no 1260 0.384016488031534 1819 4176441
SGTC_559 1550-0661 158 µM 0.293991543108423 0.37908532686765 no 1261 0.384382182797959 1826 5830875
SGTC_2330 7979373 200 µM 0.293500028373591 0.379277311923551 no 1262 0.384569988904555 1665 1863007
SGTC_3004 9076122 71.4286 µM 0.29348612163059 0.379282744313784 no 1263 0.384575303018049 1871 44782551
SGTC_1647 st011722 22.4 µM 0.291529570843253 0.380047268757528 no 1264 0.385323165639884 1831 2854783
SGTC_711 k292-0785 179 µM 0.291383357377628 0.380104420704779 no 1265 0.385379070743663 1762 4146315
SGTC_1952 st077036 64.1 µM 0.290829894593431 0.380320782045627 no 1266 0.385590710260256 1871 2937007
SGTC_246 cycloheximide 667 µM 0.289296530981222 0.380920404585881 no 1267 0.386177233378183 1775 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1267 0828-0272 9.49 µM 0.289216404153264 0.380951746096286 no 1268 0.386207889658428 1902 745334
SGTC_704 1310-0270 142 µM 0.288557737560621 0.381209412308118 no 1269 0.386459920396772 1744 5718033
SGTC_660 4031-1742 102 µM 0.287872019763029 0.381477716740903 no 1270 0.386722352845308 1787 6738706
SGTC_2083 5306046 65.942 µM 0.287794519980191 0.381508044076507 no 1271 0.386752016205042 1774 539837
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.287745929839356 0.381527058817078 no 1272 0.386770614618189 1931 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2861 9024595 19.48 µM 0.287353203702772 0.381680754510014 no 1273 0.386920944426077 1909 16482810
SGTC_98 0074-0023 107.663 µM 0.28715075496105 0.381759991309437 no 1274 0.386998445465069 1747 3563821
SGTC_2213 7173844 200 µM 0.28532781525482 0.382473697944921 no 1275 0.387696502335504 1809 892728
SGTC_2082 5219693 150 µM 0.285306308962807 0.382482120350353 no 1276 0.387704739894799 1761 2834649
SGTC_2274 7947094 46.08 µM 0.284680420319611 0.382727258436458 no 1277 0.387944496271778 1773 2971028
SGTC_1726 st035556 14.5795 µM 0.281584064619572 0.38394067915277 no 1278 0.389131230282628 1906 5919439
SGTC_2771 fluoxetine 41.05 µM 0.281469258159042 0.383985692246873 no 1279 0.389175251890195 1891 3386 A selective serotonin reuptake inhibitor.
SGTC_539 4859-0462 2.54 µM 0.281138719460401 0.384115297955854 no 1280 0.389302002219328 1946 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2904 7225135 42.03 µM 0.280547823400149 0.384347023240107 no 1281 0.389528620068 1927 4446116
SGTC_47 0149-0135 24.25 µM 0.27997709873423 0.384570877375536 no 1282 0.389747537542016 1687 5239155
SGTC_2973 9094665 17.96 µM 0.278673930866987 0.385082160354871 no 1283 0.39024753520787 1926 25237061 YIL048W NEO1
SGTC_1755 st041960 45.185 µM 0.277712610167579 0.385459451661214 no 1284 0.390616489863107 1843 2257073
SGTC_2972 9093619 59.92 µM 0.2770999752043 0.385699950221647 no 1285 0.390851670430999 1731 25236256
SGTC_643 k048-0106 28.4 µM 0.276928917041174 0.385767109386696 no 1286 0.390917344003394 1888 6763920
SGTC_2459 5811157 9.22 µM 0.276490711882148 0.38593916878228 no 1287 0.391085596279913 1916 2870684 YBR192W RIM2
SGTC_2374 9071832 200 µM 0.276396484998081 0.385976169500893 no 1288 0.391121778088571 1888 17381698
SGTC_2725 haloperidol 53.21 µM 0.276110433050089 0.386088501839521 no 1289 0.391231623816441 1827 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2228 7354201 200 µM 0.275829797014355 0.386198716635478 no 1290 0.391339398231678 1906 753451
SGTC_1177 0983-0204 23.6 µM 0.275809467273605 0.386206701135287 no 1291 0.391347205913574 1966 766818
SGTC_981 1488-1094 54.9 µM 0.27350695188765 0.387111324439608 no 1292 0.392231774582898 1813 3449522
SGTC_2427 5545055 42.75 µM 0.273409324341414 0.387149694410594 no 1293 0.392269292982901 1833 5372858
SGTC_1850 st056238 17 µM 0.27308871429706 0.387275709614904 no 1294 0.392392510905863 1900 5393177
SGTC_3253 9135987 49.47 µM 0.272795776494483 0.387390858680318 no 1295 0.392505103172953 1866 4182430
SGTC_187 1488-2104 32.728 µM 0.271756917553304 0.387799296968511 no 1296 0.392904466836181 1909 2852859
SGTC_1339 1486-1321 22.7 µM 0.270812834834261 0.388170580706344 no 1297 0.39326749393315 1797 3469382
SGTC_2041 5107442 45.335 µM 0.266391722602489 0.38991064694477 no 1298 0.394968769698198 1945 793005
SGTC_954 1189-0853 2.85 µM 0.266297778116926 0.389947645805101 no 1299 0.395004942074144 1905 2828194
SGTC_1186 1319-0216 26 µM 0.265764036939789 0.390157872006458 no 1300 0.395210470894334 1989 4565136
SGTC_1104 tacrolimus 29.8 µM 0.264642605796286 0.39059967797346 no 1301 0.395642397626562 1854 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_802 4112-3352 742 µM 0.264603025069388 0.390615274026626 no 1302 0.395657644754522 1945 704594
SGTC_988 1497-1057 103 µM 0.264530546547571 0.390643833303407 no 1303 0.395685565052256 1994 3533044
SGTC_1908 st060353 56.5 µM 0.263385117188272 0.391095253998641 no 1304 0.396126880261105 2005 4227716
SGTC_1088 bifonazole 369 nM 0.262360211273814 0.39149930010257 no 1305 0.396521872653058 1890 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2372 9071633 200 µM 0.261743525793695 0.391742470932791 no 1306 0.396759590629565 1971 21321366
SGTC_2086 5274770 176.623 µM 0.261565038365857 0.391812859822763 no 1307 0.396828400565375 1834 689278
SGTC_1934 st074720 32.6 µM 0.261463497511466 0.391852905389186 no 1308 0.396867547723643 1743 17250992
SGTC_369 0957-0393 4.5 µM 0.260632288888077 0.392180759541615 no 1309 0.3971880435497 1777 6997992
SGTC_1494 4358-1428 177 µM 0.260042953262837 0.392413257967665 no 1310 0.397415320531621 2001 1564571
SGTC_2316 5844804 197.44 µM 0.259775473167187 0.392518794047923 no 1311 0.397518485590528 1974 776813
SGTC_2781 5567276 71.43 µM 0.257808815899473 0.393294994200242 no 1312 0.398277230164809 1908 2853274
SGTC_1014 4130-3005 69.3 µM 0.257790512479213 0.393302220190579 no 1313 0.39828429351221 1800 743608
SGTC_229 benomyl 22.8748 µM 0.257462146490936 0.393431861737387 no 1314 0.398411016639185 1840 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3122 9126309 49.47 µM 0.255082336564011 0.39437178222759 no 1315 0.399329753194055 1994 17591206
SGTC_3220 9131269 49.47 µM 0.255042753935817 0.39438742084656 no 1316 0.399345038979731 1874 17722206
SGTC_213 1246-0773 967 nM 0.254798196984213 0.394484046122548 no 1317 0.399439483960678 1903 6251622
SGTC_1987 st072290 61.9 µM 0.253863953772116 0.394853228493206 no 1318 0.399800331697446 1855 54697379
SGTC_1215 3852-0577 11.2 µM 0.25283839876569 0.395258603019589 no 1319 0.400196546791755 1952 2884876
SGTC_3043 9092303 49.47 µM 0.251116768318017 0.395939372308998 no 1320 0.400861915978955 1785 25236084
SGTC_2345 9052315 157.45 µM 0.250714579548755 0.39609845212916 no 1321 0.401017393890945 1845 6469265
SGTC_2194 5927483 104.545 µM 0.250359039263787 0.396239095242051 no 1322 0.40115485151452 1898 760979
SGTC_2976 9009005 19.48 µM 0.249827645351553 0.396449326956462 no 1323 0.401360319799905 2005 2993148
SGTC_980 1473-0395 201 µM 0.249621760360977 0.396530787913982 no 1324 0.401439934437573 1818 768876
SGTC_247 mechlorethamine 29.705 µM 0.249051669414694 0.396756375046192 no 1325 0.401660406934889 1898 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1849 st056239 19.2 µM 0.248556179021083 0.396952470532487 no 1326 0.401852054431063 1758 5393181
SGTC_186 3455-3465 67.277 µM 0.248469677917569 0.396986706918567 no 1327 0.401885514049768 1883 755278
SGTC_1026 k007-1105 30.6 µM 0.248273312714945 0.397064429508068 no 1328 0.401961473030671 1850 7066794
SGTC_214 4373-3496 70 µM 0.246964513118952 0.397582564963282 no 1329 0.40246784397585 1944 3779166
SGTC_742 0kpi-0133 140 µM 0.244673448074641 0.398490000187674 no 1330 0.403354644305059 1984 2728852
SGTC_574 1315-0397 40 µM 0.244292803947035 0.398640817410595 no 1331 0.403502028146816 1907 6794277
SGTC_963 1269-2853 151 µM 0.24077646457624 0.400034759732065 no 1332 0.404864185803052 1811 3668223
SGTC_89 0302-0250 142.109 µM 0.237493790443594 0.401337223758616 no 1333 0.406136867966832 1990 4203518 YLR208W SEC13
SGTC_863 0466-0191 129 µM 0.236979440752384 0.401541401661075 no 1334 0.406336369958132 1986 765160 YPR165W RHO1
SGTC_987 1497-1013 404 µM 0.236050498792189 0.401910225525621 no 1335 0.406696742389648 1934 1676435
SGTC_1451 4152-0210 104 µM 0.235696757589994 0.402050696683029 no 1336 0.406833993045124 1994 659563
SGTC_1862 st057513 3.81 µM 0.235682668944102 0.40205629156738 no 1337 0.406839459639725 1881 5393163
SGTC_226 1,3-diallylurea 8.28947 mM 0.234234908120003 0.402631333275369 no 1338 0.407401307976848 1926 74537 YKL182W FAS1
SGTC_332 4112-0506 40.9 µM 0.23364181434289 0.402866967397427 no 1339 0.407631531436546 1893 2790355
SGTC_1526 st051518 75 µM 0.232673615211002 0.403251705367243 no 1340 0.408007429481943 1850 673993
SGTC_723 4182-0001 115 µM 0.232148802920187 0.403460291736184 no 1341 0.408211220414564 1855 744821 YLR208W SEC13
SGTC_469 w7 172 µM 0.230136544599177 0.404260316797053 no 1342 0.408992834211247 1944 45115570 A P450 inhibitor.
SGTC_3235 9132602 49.47 µM 0.227366394514358 0.405362315857866 no 1343 0.410069424651305 1931 4912240
SGTC_1347 1493-0251 600 nM 0.226725712109437 0.405617294235529 no 1344 0.410318516166888 1992 3986378
SGTC_1553 gossypol 38.6 µM 0.225472036645689 0.40611634697841 no 1345 0.410806038422054 1975 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1844 rapamycin 4 nM 0.224790045778244 0.406387892383582 no 1346 0.411071305118729 1912 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2552 juarezic acid 87.02 µM 0.223850690644199 0.406761985123891 no 1347 0.41143674260571 2038 1549512
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.222536003713702 0.407285694400159 no 1348 0.411948324461702 1937 16486 A toxic proline analog.
SGTC_3313 9133968 57.047 µM 0.221953943298043 0.407517612824074 no 1349 0.412174868484815 1942 1494643
SGTC_2737 bleomycin 30.5 nM 0.221074625097406 0.407868033256128 no 1350 0.412517163842146 1961 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1836 st055642 81 µM 0.221072644132277 0.407868822781382 no 1351 0.412517935054788 1825 8571
SGTC_2123 5259487 200 µM 0.220685270325523 0.408023220066756 no 1352 0.412668750645926 1980 2173474
SGTC_2679 rapamycin 1 nM 0.220470614242543 0.408108782639645 no 1353 0.412752327890085 1935 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2815 7968870 71.43 µM 0.220098128269173 0.408257267087856 no 1354 0.412897366247439 1883 2977326 YHR190W ERG9
SGTC_2588 indole-3-carbinol 100 µM 0.219688566716705 0.408420546216136 no 1355 0.4130568547956 2025 3712 Induces cell cycle arrest.
SGTC_3126 9127922 49.47 µM 0.217991454244314 0.409097299974319 no 1356 0.413717884923224 1949 45595682
SGTC_2456 5770359 74.46 µM 0.217487219102825 0.40929842501905 no 1357 0.413914333157377 2014 3118787
SGTC_2800 7887935 81.82 µM 0.214140819067956 0.410633811379018 no 1358 0.415218622500876 1938 2961002
SGTC_1403 3909-7815 62.9 µM 0.213206047431866 0.411007019405343 no 1359 0.415583125771382 1929 6615483
SGTC_514 4466-0038 2.65 nM 0.211683895591145 0.411614911531875 no 1360 0.416176826423126 1938 5722064
SGTC_1564 D-Arginine 115 µM 0.209786782699082 0.412372846397888 no 1361 0.416917044699603 1834 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1614 st002383 48.6 µM 0.208681291581468 0.41281466333547 no 1362 0.417348522880052 2071 1947235
SGTC_2905 7799065 20.05 µM 0.208572791430556 0.412858032110437 no 1363 0.417390876352381 2034 1296806
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.208156227477815 0.413024547454241 no 1364 0.417553492674367 1953 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3016 9080866 49.47 µM 0.207568739690112 0.413259413691607 no 1365 0.417782857418575 1944 17066299
SGTC_639 0833-0042 114 µM 0.207488027593875 0.413291683251619 no 1366 0.417814370914842 1898 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1673 st016611 27.3 µM 0.207398866612837 0.413327331447149 no 1367 0.417849183834979 2016 5226799
SGTC_2696 st077691 74.316 µM 0.206836092866294 0.413552355189682 no 1368 0.418068933784131 1957 757133
SGTC_860 0443-0016 25.1 µM 0.205520402070705 0.414078541688151 no 1369 0.41858277987648 2080 5337942
SGTC_2608 thymoquinone 42.66 µM 0.205244357639749 0.41418896022693 no 1370 0.41869060733435 2051 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_541 4513-1321 94 µM 0.204644247624794 0.414429029289617 no 1371 0.418925041162537 1881 747515
SGTC_1711 st032263 62.8 µM 0.204557091713513 0.414463897954049 no 1372 0.418959091139225 1985 3958979
SGTC_2789 5281112 71.43 µM 0.204125437381511 0.414636600819674 no 1373 0.419127738328223 1862 765948
SGTC_1887 st057648 70.8 µM 0.203380703673567 0.41493460404758 no 1374 0.41941874043393 2061 688672
SGTC_133 0724-0033 378.92 µM 0.201933617388711 0.415513791637686 no 1375 0.419984310266315 2058 280309
SGTC_2786 7743617 45.45 µM 0.201845898764817 0.415548906404657 no 1376 0.420018598970135 1863 583674
SGTC_9 0092-0002 10.449 µM 0.201246046657487 0.415789052115096 no 1377 0.420253093954707 2002 759368
SGTC_2 0422-0095 29 µM 0.201093284602858 0.415850214137933 no 1378 0.420312816426468 1973 6790840
SGTC_3045 9092950 49.47 µM 0.200771176470868 0.415979184681027 no 1379 0.420438750920713 2087 44120432
SGTC_316 k060-0003 58.6 µM 0.200237012597245 0.416193081260263 no 1380 0.420647610713878 2023 6152314
SGTC_2821 7996764 71.43 µM 0.200153753555036 0.416226423125056 no 1381 0.420680167281186 1968 2987135
SGTC_2464 5717415 7.67 µM 0.199722032366486 0.416399319588999 no 1382 0.420848990793231 1868 5285744
SGTC_1573 oleylamine 1.06 µM 0.199536136276858 0.416473772567664 no 1383 0.420921689488635 1916 5356789 An amine of the fatty acid oleic acid.
SGTC_873 0591-4978 488 µM 0.197082127590326 0.41745690400961 no 1384 0.42188163462657 2095 3305145
SGTC_3173 9105693 49.47 µM 0.196928868754703 0.417518320159048 no 1385 0.421941601008907 2009 17096658
SGTC_1667 st014849 34.6 µM 0.196336834850343 0.417755587636321 no 1386 0.422173266183825 2037 5348460
SGTC_1120 ficusin 1.78878 µM 0.195883973181168 0.41793709973174 no 1387 0.422350490902808 2013 6199 A DNA cross-linker.
SGTC_2560 caryophyllene 100 µM 0.195881053886721 0.41793826987483 no 1388 0.422351633402354 2031 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_685 1278-0033 54.9 µM 0.195377090651542 0.418140284733986 no 1389 0.422548875009401 2029 3590572
SGTC_3195 9113082 49.47 µM 0.1949055396053 0.418329326650581 no 1390 0.422733448692688 2114 17018038
SGTC_587 k089-0003 57 µM 0.194364321578462 0.418546320883056 no 1391 0.422945312210131 2078 9659696
SGTC_1770 st043884 66.3 µM 0.194112846003867 0.418647155138341 no 1392 0.423043761640243 2052 670149
SGTC_984 1492-0255 2.91 µM 0.193330401598245 0.418960926326591 no 1393 0.423350109202341 1973 1585198
SGTC_1971 st069429 63.5 µM 0.192473236150072 0.41930472087058 no 1394 0.423685765205858 2066 1246522 YGL099W LSG1
SGTC_1788 fluconazole 20 µM 0.1921847483686 0.419420442305335 no 1395 0.423798746128237 1921 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2137 5261020 140 µM 0.191982658802304 0.419501510876872 no 1396 0.423877894513663 1959 763655
SGTC_433 pimozide 108 µM 0.191871537346301 0.419546088893189 no 1397 0.423921416544336 1809 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.186970298053239 0.421513312744598 no 1398 0.425841960487879 2053 94937 An inhibitor of serotonin biosynthesis.
SGTC_2778 tioconazole 65.09 nM 0.186854373936876 0.421559865452075 no 1399 0.425887406685814 1998 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1125 tnp00248 1.32998 µM 0.18683348637007 0.421568253579872 no 1400 0.425895595427387 2090 24207736
SGTC_1266 0828-0227 32.9 µM 0.185661933057493 0.422038788367744 no 1401 0.426354941121028 1995 3913820
SGTC_69 0096-0274 206.684 µM 0.184743224041769 0.422407850375362 no 1402 0.426715220893751 2045 6741392
SGTC_2967 9089538 49.85 µM 0.183525433693556 0.422897163719239 no 1403 0.427192882233487 2112 728216
SGTC_2092 5303694 80.6725 µM 0.183473951046888 0.422917852292208 no 1404 0.427213077943194 1941 1963699
SGTC_475 α-linolenic acid 10 µM 0.182784938285461 0.423194756142048 no 1405 0.427483383508769 2086 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1490 4089-0339 670 nM 0.182118608163152 0.423462580273529 no 1406 0.427744822865454 2086 742542
SGTC_2883 9059145 45.46 µM 0.180053628520183 0.424292800433801 no 1407 0.428555233318147 1967 16476510
SGTC_1583 clindamycin 39.6 µM 0.17914674317711 0.424657517949658 no 1408 0.428911239946273 1897 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2706 st078239 82.5 µM 0.178849296616743 0.424777154601206 no 1409 0.429028018086524 2074 15434492
SGTC_2420 aureobasidin a 50 nM 0.177831262424755 0.425186672806424 no 1410 0.429427747391835 2091 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2281 7943571 200 µM 0.17705817683148 0.425497711040899 no 1411 0.429731346436723 2145 1244024
SGTC_1624 st003710 6.25 µM 0.176192324275556 0.425846127575487 no 1412 0.43007142539888 2077 24207033
SGTC_2591 skatole 100 µM 0.17610123659587 0.42588278436191 no 1413 0.430107204722641 1988 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1163 k060-0048 49.9 µM 0.176057855549019 0.425900242598697 no 1414 0.430124245039235 2057 6809982
SGTC_2772 vinpocetine 57.06 µM 0.176030073636388 0.425911423207604 no 1415 0.430135157997471 2072 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_370 0180-0345 38.7 µM 0.17513571276546 0.426271383371403 no 1416 0.430486498593063 1961 3989527
SGTC_2711 st079103 59.1 µM 0.174006300730254 0.426726034084845 no 1417 0.430930255253686 2073 54693780
SGTC_1919 st067113 52.3 µM 0.173599765392967 0.426889710872634 no 1418 0.431090008205177 1997 1268243
SGTC_1485 3909-9022 254 µM 0.172770978814678 0.427223430853727 no 1419 0.431415724756831 2090 714516
SGTC_2776 terbinafine 19.92 µM 0.172566686864251 0.427305699253367 no 1420 0.43149601951193 2099 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1972 st070201 17.4 µM 0.17140078000248 0.427775270525014 no 1421 0.431954320750873 2122 2829099
SGTC_1369 1866-0067 208 µM 0.171396487805713 0.427776999405097 no 1422 0.431956008121355 2092 3531355
SGTC_3037 9091026 49.47 µM 0.171264613962282 0.427830118349495 no 1423 0.432007851650184 2069 25236398 YIL048W NEO1
SGTC_1699 st031318 29.054 µM 0.170119917270147 0.428291258422067 no 1424 0.432457915054904 2075 5340658
SGTC_1966 st070145 16.1 µM 0.170059125980823 0.428315750884605 no 1425 0.432481818981901 2033 3748532
SGTC_244 nsc-207895 1.295 µM 0.169603207274701 0.428499446716704 no 1426 0.432661100027804 1989 42640
SGTC_3336 9143619 71.43 µM 0.169037272525885 0.428727491051789 no 1427 0.43288366199538 2112 45595730
SGTC_664 1222-0054 14.9 µM 0.16855496632012 0.428921855913248 no 1428 0.4330733526452 2047 6813991
SGTC_2098 5376439 882.5 nM 0.167449792008857 0.429367295687562 no 1429 0.433508074914975 2079 2844116
SGTC_3324 9138759 60.749 µM 0.16470189035476 0.430475224321118 no 1430 0.434589314507581 2045 45595710
SGTC_938 3126-1755 342 µM 0.164555897471317 0.430534102700918 no 1431 0.434646773298234 2140 1777771
SGTC_1504 k297-0033 30 µM 0.164388403264209 0.430601654385696 no 1432 0.434712696119813 1941 4388117
SGTC_1846 st056244 14.8 µM 0.163613425609296 0.430914235160044 no 1433 0.435017737514915 2049 5393182
SGTC_2282 7944268 200 µM 0.163073664600747 0.431131968844331 no 1434 0.435230217407965 2082 2970414
SGTC_1979 st071809 45.3 µM 0.162153796040972 0.431503081952342 no 1435 0.435592371796964 2077 4976333
SGTC_1128 3448-9350 235 µM 0.16178352789001 0.431652480560588 no 1436 0.435738162494259 1954 619386
SGTC_2344 7990960 76.95 µM 0.16079740759017 0.432050415511651 no 1437 0.436126483555529 1995 140813
SGTC_1942 st076330 65.2 µM 0.160466179761757 0.432184093323639 no 1438 0.436256930503838 2073 24208414
SGTC_1669 st015249 58.4 µM 0.160279852073026 0.432259295363383 no 1439 0.436330314700218 2168 722793
SGTC_2172 5754775 163.918 µM 0.160223033918142 0.432282227715411 no 1440 0.436352692672775 1987 2263357
SGTC_1082 camptothecin 424.86 nM 0.158884420411165 0.432822570798212 no 1441 0.436879967738699 1885 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2154 5570129 200 µM 0.158876463051511 0.432825783232863 no 1442 0.436883102450413 2109 673366
SGTC_3164 9100705 49.47 µM 0.158671788274996 0.432908413214208 no 1443 0.436963733121924 2121 17174235
SGTC_519 k048-0011 62.8 µM 0.158518895121486 0.432970140166926 no 1444 0.437023966373947 2011 6836379
SGTC_2183 6420625 130.508 µM 0.158108438694791 0.433135860213835 no 1445 0.437185675568657 2093 2897619
SGTC_2322 7413319 38.22 µM 0.157734147563279 0.433286988926731 no 1446 0.437333145723431 2026 1840400
SGTC_22 0964-0034 14.468 µM 0.157225771134033 0.43349227330466 no 1447 0.437533459228202 2030 138402
SGTC_3266 9136860 49.47 µM 0.157218392511953 0.433495252953175 no 1448 0.437536366714773 2070 4871271 YPR165W RHO1
SGTC_1706 st031321 9.9705 µM 0.156089264135979 0.433951264063825 no 1449 0.437981330309573 2117 6103185
SGTC_483 fpl-64176 144 µM 0.15407633824497 0.43476442436698 no 1450 0.438774772413334 2131 3423
SGTC_2238 6671620 73.2395 µM 0.152891217268546 0.435243306200855 no 1451 0.43924203104187 2161 729941
SGTC_157 1348-1695 65.819 µM 0.15160155071348 0.435764540560389 no 1452 0.439750605126762 2124 5380510
SGTC_2946 9065502 71.43 µM 0.151198802417441 0.435927339072905 no 1453 0.439909447483715 2154 16489101
SGTC_73 0327-0325 16.231 µM 0.150717913762828 0.436121737621647 no 1454 0.440099120761329 2161 53298
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.14873615671401 0.436923022402454 no 1455 0.440880914811463 2123 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_568 1193-0097 7.48 µM 0.148250119182138 0.43711958184408 no 1456 0.441072689694156 2117 3646150
SGTC_897 1000-0139 31.4 µM 0.147687979964397 0.43734693708119 no 1457 0.441294509101796 2156 6151020
SGTC_327 1273-0057 3.96 µM 0.144455020284599 0.438654895700743 no 1458 0.44257058622723 2143 3108138
SGTC_939 1165-0479 45.3 µM 0.144261611662113 0.438733164423634 no 1459 0.442646945308658 2171 1377347
SGTC_3208 9114115 49.47 µM 0.143323522414596 0.439112824908137 no 1460 0.44301733970382 1935 650895
SGTC_999 SEC7.066 22.7 µM 0.142405528626398 0.439484406659163 no 1461 0.44337984784048 2057 740511 YDR170C SEC7
SGTC_1709 st033179 39.1045 µM 0.142164161778622 0.439582115006037 no 1462 0.443475169488546 2151 573381
SGTC_1286 0929-0070 131 µM 0.141759560595542 0.43974591092542 no 1463 0.443634963686404 2101 1420408
SGTC_1103 duloxetine 36.1 µM 0.141529372720525 0.439839103183525 no 1464 0.443725878750633 2136 60835 A selective serotonin reuptake inhibitor.
SGTC_2833 9001315 45.46 µM 0.140936441397045 0.440079168564971 no 1465 0.443960076693088 2002 2989378
SGTC_1287 0971-0001 34.6 µM 0.140291143040186 0.440340461285955 no 1466 0.444214980974868 2072 4665869
SGTC_1107 amlodipine 47 µM 0.139132865741959 0.440809533355186 no 1467 0.444672578843539 2110 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1411 3909-8223 150 µM 0.139112882067964 0.440817626952249 no 1468 0.444680474395198 2174 X1411
SGTC_3163 9099914 49.47 µM 0.139082743171103 0.440829833567586 no 1469 0.444692382317974 2170 16268368
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.138982376208735 0.440870483798501 no 1470 0.444732037813249 2059 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3151 9099821 49.47 µM 0.138735954256316 0.440970291286832 no 1471 0.444829402720517 2061 17174189
SGTC_2250 alverine citrate 130 µM 0.1387305435074 0.4409724828271 no 1472 0.444831540623694 2017 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_273 hydroxyurea 18.1 mM 0.136683826346303 0.441801603068912 no 1473 0.445640357121101 2121 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1937 st074714 47.2 µM 0.13539058740778 0.442325622809417 no 1474 0.446151532885742 2103 17250970
SGTC_1896 st058441 89 µM 0.133489875208315 0.443095973325294 no 1475 0.446902985511653 2017 688759
SGTC_2918 7977171 22.06 µM 0.133339908826419 0.443156763252825 no 1476 0.4469622833497 2126 2236483
SGTC_893 0958-0369 48.9 µM 0.13313913863077 0.44323814895793 no 1477 0.44704167125485 2195 6819948
SGTC_1539 benzyladenosine 56 µM 0.132245403456639 0.443600469128357 no 1478 0.447395094848728 2116 92208 A nucleotide analog.
SGTC_1197 1601-0112 267 µM 0.130891040176728 0.444149617671115 no 1479 0.447930751302939 2044 7350313
SGTC_40 0327-0103 19.753 µM 0.130736753371213 0.444212182581045 no 1480 0.44799177843614 2081 409036
SGTC_2943 9068529 45.32 µM 0.128866358965167 0.444970757163606 no 1481 0.448731698161764 2177 3270634
SGTC_384 k007-0144 5.16 µM 0.126834275905111 0.445795136075224 no 1482 0.449535783278041 2084 6824886
SGTC_1521 st012942 49.4 µM 0.125574170261042 0.446306455847134 no 1483 0.450034505110161 2193 24207259
SGTC_1765 st044815 90.4 µM 0.125334832049178 0.446403583503506 no 1484 0.450129238802111 2020 645695
SGTC_2224 6650123 117.647 µM 0.125191759617632 0.446461646348952 no 1485 0.45018587039658 2134 2908370
SGTC_756 0508-1999 28.3 µM 0.125147951449334 0.446479425174178 no 1486 0.450203210952159 1986 6753853
SGTC_2106 5357045 167.29 µM 0.12383480544003 0.447012393690046 no 1487 0.450723036575365 2155 668842
SGTC_471 1-acyl-paf 4 µM 0.123368683650951 0.447201602297615 no 1488 0.450907577215727 2105 16759367
SGTC_1306 1185-0270 9.02 µM 0.121488442279057 0.447964953265654 no 1489 0.451652084310807 2159 1548076
SGTC_2273 7815444 169.05 µM 0.121487852720492 0.44796519264833 no 1490 0.451652317781334 2211 2824616
SGTC_2526 patulin 37.61 µM 0.121244331532698 0.448064072915519 no 1491 0.451748755804252 2112 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1238 0333-0287 48.8 µM 0.120205465572228 0.44848593416652 no 1492 0.452160194135874 2121 7226
SGTC_1416 3966-0321 25.3 µM 0.118473061124742 0.449189555912451 no 1493 0.452846419429527 2123 582530 YLR208W SEC13
SGTC_651 3253-0966 34.4 µM 0.116536948772234 0.449976103304195 no 1494 0.453613502345002 2122 781462
SGTC_103 0844-0104 51.839 µM 0.116139953177188 0.450137407507345 no 1495 0.453770812493962 2187 5375804
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.115729554989947 0.450304166008283 no 1496 0.45393344106626 2166 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2531 methyl deoxycholate 70.07 µM 0.114888448085962 0.450645963244632 no 1497 0.454266770776844 2105 16667744 Haematoxylin.
SGTC_2746 daunorubicin 9.88 µM 0.114555649875778 0.45078121123836 no 1498 0.454398667236581 2203 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_119 0121-0043 24.815 µM 0.113420617075751 0.451242527369912 no 1499 0.454848547557882 2208 1092378
SGTC_2443 5493264 126.67 µM 0.113350272611492 0.451271119938656 no 1500 0.454876431122373 2170 5340055
SGTC_560 2332-1943 155 µM 0.112322680128541 0.451688829152162 no 1501 0.45528377972576 2199 21177716
SGTC_2819 7996655 46.38 µM 0.112090484547668 0.451783222470158 no 1502 0.455375831054591 2184 6456960
SGTC_599 1935-0052 86.5 µM 0.112058444743657 0.451796247666937 no 1503 0.455388533063072 2190 9557311
SGTC_118 0083-0097 135.343 µM 0.11201980652744 0.451811955396627 no 1504 0.455403851037347 2171 5207356
SGTC_2593 nobiletin 86.24 µM 0.111759218075775 0.451917895303615 no 1505 0.455507162070964 2095 72344 An anti-infammatory.
SGTC_3100 9120536 49.47 µM 0.111730720880649 0.451929480791528 no 1506 0.455518460047742 2240 16421196
SGTC_793 0488-0545 106 µM 0.11114367939267 0.452168150638457 no 1507 0.455751206069377 2028 292548
SGTC_600 1495-0418 41.6 µM 0.110176281391001 0.45256149736854 no 1508 0.456134786224097 2136 5377768
SGTC_3255 9139072 49.47 µM 0.110136044550248 0.45257785879163 no 1509 0.456150741304342 2117 17646060
SGTC_455 paf C-16 10 µM 0.109447714298511 0.452857765542239 no 1510 0.456423695243173 2175 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1021 4476-0760 85.3 µM 0.109262117068084 0.452933241931183 no 1511 0.45649729642732 2022 746768
SGTC_1472 k841-0093 193 µM 0.10702574085133 0.453842836697143 no 1512 0.457384279395603 2189 X1472
SGTC_3090 9117696 49.47 µM 0.106112492828286 0.454214349304831 no 1513 0.457746549632841 2209 7923821
SGTC_757 1066-0008 322 µM 0.10575277243785 0.454360695879921 no 1514 0.457889254358014 2182 6842497
SGTC_1670 st016595 4.04 µM 0.104177259619963 0.455001741190001 no 1515 0.458514339979128 2235 597879
SGTC_2326 6164455 177.58 µM 0.103692578751632 0.455198971993313 no 1516 0.458706658102665 2135 2888790
SGTC_2302 7771753 200 µM 0.102572646804915 0.45565474717652 no 1517 0.459151076496762 2109 2203047
SGTC_3242 9133940 49.47 µM 0.102100773318121 0.455846801557638 no 1518 0.459338343602327 2198 17248444
SGTC_141 0443-0274 32.331 µM 0.101402783124558 0.456130905240515 no 1519 0.45961536362507 2230 1627241
SGTC_2329 6138490 200 µM 0.100617809041638 0.456450440857999 no 1520 0.459926929441084 2086 720019
SGTC_642 0335-0876 158 µM 0.100184134094632 0.456626986920409 no 1521 0.460099070898379 2147 6812350
SGTC_2120 5538279 151.968 µM 0.0982370725087455 0.457419727201585 no 1522 0.460872022607439 2155 2058197
SGTC_1387 3342-1166 1.8 µM 0.098056755649351 0.457493151290877 no 1523 0.460943612986221 2149 3418228
SGTC_3007 9078383 71.4286 µM 0.0980443272991347 0.457498212104056 no 1524 0.460948547403976 2132 6496995
SGTC_855 0428-0020 25 µM 0.0974388406757997 0.45774477405054 no 1525 0.461188950531889 2109 6812414
SGTC_2913 7966556 36.57 µM 0.0969653830002089 0.457937583445186 no 1526 0.46137694261571 2223 2976516
SGTC_217 ketoconazole 989 nM 0.0965209026532556 0.4581186012143 no 1527 0.461553436756815 2212 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3109 9122853 49.47 µM 0.0963985595889665 0.458168427819856 no 1528 0.461602018039517 2168 1234709
SGTC_1075 aripiprazole 15.2 µM 0.0962515775401348 0.458228290002934 no 1529 0.461660383989351 2184 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1284 0929-0043 16 µM 0.095614270395596 0.458487860513063 no 1530 0.461913465496623 2133 1239883
SGTC_2920 7982904 15.77 µM 0.0954469131212342 0.458556026838594 no 1531 0.46197992742734 2151 6456808
SGTC_2078 5212016 200 µM 0.0940632249407989 0.45911966366337 no 1532 0.46252946653114 2263 1899708
SGTC_2391 6285546 200 µM 0.0925145080393054 0.459750621339906 no 1533 0.463144632452978 2211 846083
SGTC_1986 st071812 45 µM 0.0923851567864594 0.459803324519126 no 1534 0.463196016079658 2241 11838594
SGTC_2074 5212007 75.395 µM 0.0919822589671597 0.459967486677957 no 1535 0.463356067560983 2251 758611
SGTC_2848 9016370 25.97 µM 0.0898823707694819 0.460823203489226 no 1536 0.464190345264468 2243 7894410
SGTC_717 1532-0246 73.2 µM 0.0890279691251254 0.461171429349898 no 1537 0.464529841111963 2154 9561992
SGTC_224 benfluorex 43.875 µM 0.0889881470745672 0.461187660229305 no 1538 0.46454566500543 2248 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1725 st036284 20.55 µM 0.0870204412339427 0.461989748040165 no 1539 0.465327631992816 2244 707914
SGTC_952 1185-0122 232 µM 0.0852879942204119 0.462696066362525 no 1540 0.466016217989535 2257 678600
SGTC_1105 epirubicin 18.1 µM 0.0839116884242458 0.463257269934513 no 1541 0.466563323159751 2186 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3297 9117502 71.43 µM 0.0836647213850314 0.463357981186594 no 1542 0.466661503511948 2287 7453720
SGTC_1808 st050063 61.5 µM 0.0829891065494598 0.463633503681729 no 1543 0.466930100723981 2252 4011993
SGTC_2099 5377090 177.372 µM 0.0815958155792282 0.464201756623415 no 1544 0.46748406444226 2167 2243829
SGTC_1912 st060209 90.8 µM 0.0815465235738867 0.464221861684557 no 1545 0.467503663793061 2164 688787
SGTC_314 1671-0008 2.74 µM 0.0811454407763783 0.464385457409362 no 1546 0.467663144149784 2204 3913060
SGTC_3307 9126885 69.2785 µM 0.0794951281218333 0.46505865852293 no 1547 0.468319403273456 2212 24824909
SGTC_3024 9090631 49.47 µM 0.0788021352989443 0.465341376426182 no 1548 0.468595002804213 2283 25236383
SGTC_1620 st003704 16.5 µM 0.0783484045697309 0.465526492880498 no 1549 0.468775457244291 2249 2834414
SGTC_2626 ethyl orsellinate 100 µM 0.0776630622412292 0.46580611809743 no 1550 0.469048038692836 2233 75653 A natural product.
SGTC_3026 9090633 49.47 µM 0.0774330860701738 0.465899954026491 no 1551 0.469139510454792 2232 25236842
SGTC_252 miconazole 1.30953 nM 0.0771770551272628 0.466004423172678 no 1552 0.469241347275477 2280 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1790 st045711 43.5 µM 0.077103515936788 0.466034430043371 no 1553 0.469270598008167 2259 585119
SGTC_2587 piperic acid 92.2 µM 0.0766792027618269 0.466207570207676 no 1554 0.469439374806409 2196 5370536
SGTC_661 1304-0007 33.6 µM 0.0764107910089656 0.46631709840509 no 1555 0.469546142361414 2206 3117130
SGTC_2037 5169046 200 µM 0.0757909467749916 0.466570042002511 no 1556 0.469792709417848 2209 5718022
SGTC_1191 1487-1166 10.6 µM 0.0739434915958283 0.467324023947024 no 1557 0.470527674629782 2217 3955771
SGTC_262 fenpropimorph 62.5 µM 0.0734074340720366 0.467542821386405 no 1558 0.470740951012022 2261 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_149 3970-0822 46.1 µM 0.072447594063248 0.467934614499837 no 1559 0.4711228548449 2267 3114250 YBL034C STU1
SGTC_2662 daunorubicin 22.37 µM 0.0719048152591951 0.468156182902951 no 1560 0.471338828974523 2248 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_54 0159-0055 9 µM 0.0716146616726989 0.468274630905904 no 1561 0.471454285854262 2291 3319099
SGTC_946 3434-1334 87.4 µM 0.0712896093124344 0.468407328802517 no 1562 0.471583632378391 2241 4047976
SGTC_2567 aureobasidin a 60 nM 0.0709518749553238 0.468545207657859 no 1563 0.47171802856347 2174 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2656 pseudo-anisatin 100 µM 0.0703735559912295 0.468781313079623 no 1564 0.471948169157534 2246 6708809 A neurotoxin.
SGTC_1368 1852-0141 284 µM 0.0701880293091903 0.46885705882863 no 1565 0.472022001027493 2217 2838987
SGTC_2486 5283202 22.39 µM 0.0692547001438128 0.469238130047652 no 1566 0.472393441582586 2176 1377751
SGTC_1732 st034308 51.822 µM 0.0691838513525321 0.46926705822694 no 1567 0.472421638529828 2222 830119
SGTC_15 0266-0086 27.098 µM 0.0683554338185497 0.469605320328774 no 1568 0.472751348734783 2278 1712902 YIL048W NEO1
SGTC_564 3555-0129 330 µM 0.0681073988683197 0.469706603032953 no 1569 0.472850070295122 2291 563260
SGTC_3135 9127742 49.47 µM 0.0679934260387731 0.469753143407574 no 1570 0.472895433718126 2156 3643468
SGTC_592 k241-0073 46.5 µM 0.067117508585512 0.470110834736734 no 1571 0.473244077744333 2288 4230158
SGTC_603 3794-0023 45.9 µM 0.0669730595220392 0.470169824557463 no 1572 0.473301575210166 2282 3802260
SGTC_1678 st019265 80.2 µM 0.0666803430715675 0.470289365524396 no 1573 0.473418091717154 2301 5367020
SGTC_96 0929-0093 37.281 µM 0.066320848907468 0.470436181161034 no 1574 0.473561192368817 2163 6991579
SGTC_2514 salinomycin 42.74 µM 0.0643121466940719 0.471256598601625 no 1575 0.474360840907504 2296 23682228 A polyether potassium ionophore.
SGTC_3341 9147222 25.867 µM 0.0642884237735722 0.471266288527534 no 1576 0.474370285438977 2218 1939759
SGTC_3107 9121808 49.47 µM 0.0640095734579417 0.471380189727494 no 1577 0.474481301962555 2291 662681
SGTC_1827 berberine 7.24 µM 0.0636937014735825 0.47150921589116 no 1578 0.474607060030505 2250 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_405 ebelactone b 50 µM 0.0626676382268326 0.471928358792725 no 1579 0.47501558383781 2163 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_624 k048-0052 28 µM 0.0607447677654599 0.472713927368485 no 1580 0.475781238982885 2220 6835531
SGTC_2438 5259590 200 µM 0.0605259606745859 0.472803325495957 no 1581 0.475868370060072 2270 1201127
SGTC_1488 4013-0813 75.9 µM 0.0601167183101842 0.472970533536457 no 1582 0.476031337379497 2240 2910057
SGTC_1562 morin hydrate 59.1 µM 0.0599567380589279 0.473035899483986 no 1583 0.476095045347385 2240 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1322 1348-1070 12 µM 0.0591345451709773 0.47337184872286 no 1584 0.476422471853608 2284 6758089
SGTC_3175 9106517 49.47 µM 0.0591294877045027 0.473373915270051 no 1585 0.476424485966468 2241 41468073
SGTC_2339 9000433 200 µM 0.0586016625337453 0.473589595493061 no 1586 0.476634693225157 2229 2988954
SGTC_1227 3909-8010 46.6 µM 0.0585603345127585 0.473606483300273 no 1587 0.476651152454007 2236 15982272
SGTC_667 1498-1044 59 µM 0.0578100492656719 0.473913079452393 no 1588 0.476949966705778 2235 6739982
SGTC_3306 9127676 59.7925 µM 0.0572088917430353 0.474158747292259 no 1589 0.477189397588012 2212 41905287
SGTC_529 4076-0302 30.3 µM 0.0569574509615193 0.47426150350299 no 1590 0.477289544649502 2150 5816522
SGTC_1053 3366-3204 134 µM 0.0557809032245839 0.474742345470606 no 1591 0.477758174136564 2245 3632071 YPR165W RHO1
SGTC_2406 ethylparaben 405.7 µM 0.0555443925680282 0.474839009208092 no 1592 0.477852382180085 2134 8434 A possible steroid mimic.
SGTC_1520 flindersine 88 µM 0.0554930604720771 0.474859989229169 no 1593 0.477872829187003 2299 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1750 st081859 2.357 µM 0.0553756236604716 0.474907987273871 no 1594 0.477919607766657 2266 5291695
SGTC_1884 5633444 25 µM 0.0543267701156197 0.475336684253816 no 1595 0.478337410787221 2271 5724239
SGTC_1581 himbacine 57.9 µM 0.0536830809203507 0.475599792938973 no 1596 0.478593831415972 2259 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2870 9038528 12.99 µM 0.0526675257943264 0.476014923834273 no 1597 0.478998406880529 2206 6463316
SGTC_1167 k781-0610 148 µM 0.0525125785552695 0.476078264287766 no 1598 0.479060136463136 2252 4525169
SGTC_386 1509-0011 3.07 µM 0.0518196134098984 0.47636154696802 no 1599 0.479336213652631 2308 3107280
SGTC_3284 9108171 64.8615 µM 0.0501224488888361 0.477055394392029 no 1600 0.480012405296559 2251 8687505
SGTC_3202 9113761 49.47 µM 0.0501085342043513 0.477061083387226 no 1601 0.480017949485856 2287 4798415
SGTC_884 0851-0618 334 µM 0.0494065352971948 0.477348100494741 no 1602 0.480297660055147 2307 9642473
SGTC_2629 bisabolol 100 µM 0.0491329972351842 0.47745994161244 no 1603 0.480406653581295 2275 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2186 6124449 200 µM 0.0489205162470859 0.477546819636887 no 1604 0.480491319417531 2289 3834182 YLR033W RSC58
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0486009525359454 0.477677483047341 no 1605 0.480618655424999 2233 2374 Ca(2+)-ATPase inhibitor.
SGTC_161 4065-0411 162.148 µM 0.0484373921447218 0.477744360651884 no 1606 0.480683829821366 2276 1906281 YLR208W SEC13
SGTC_2683 piperine 63.03 µM 0.0483903966145809 0.4777635765967 no 1607 0.48070255636584 2287 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2136 5328288 199.296 µM 0.0474883675127743 0.478132416139049 no 1608 0.481062000628543 2282 262395
SGTC_2258 7960471 200 µM 0.0472743107978675 0.478219946654012 no 1609 0.481147301099194 2183 2974708
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0462282008233873 0.478647729370355 no 1610 0.481564182745023 2211 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1317 1273-0028 910 nM 0.044397166329794 0.479396547907058 no 1611 0.482293910182354 2310 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_193 1273-0060 1.558 µM 0.0426969296244865 0.480091940650204 no 1612 0.482971563572093 2326 2847393 YHR072W ERG7
SGTC_340 k038-0059 454 µM 0.0422844339753251 0.480260659597502 no 1613 0.483135977038042 2334 23733424
SGTC_2739 tacrine 100.86 µM 0.0415667140020631 0.480554229792579 no 1614 0.483422054337487 2283 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0415585329108999 0.480557576179011 no 1615 0.483425315302855 2331 165521
SGTC_1333 1482-0047 286 µM 0.0413981446950699 0.480623181512119 no 1616 0.483489245924897 2339 3811116
SGTC_648 0375-0473 33.3 µM 0.0410512825952355 0.480765064074889 no 1617 0.483627506346163 2295 1713139
SGTC_2612 dictamnine 15.46 µM 0.0404988299542891 0.48099104765494 no 1618 0.483847719919528 2283 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1939 st074455 53.6 µM 0.0404101512326762 0.481027322710728 no 1619 0.483883068673821 2345 1644229
SGTC_1326 1431-2094 10.8 µM 0.0388587276616447 0.481661975599298 no 1620 0.484501511126169 2333 616278
SGTC_167 3672-0051 66.205 µM 0.0373332474281642 0.482286060972866 no 1621 0.485109648174199 2338 3237971
SGTC_850 0388-0143 75.9 µM 0.0370924069399885 0.482384594624884 no 1622 0.485205663124025 2325 67273
SGTC_1210 3013-0140 750 nM 0.0366169924111515 0.482579101326752 no 1623 0.485395197315595 2353 905973
SGTC_1050 3232-1156 69.3 µM 0.0355890456409455 0.482999680072237 no 1624 0.48580502155096 2295 700529
SGTC_1232 0279-0259 161 µM 0.0355429756309911 0.483018529808862 no 1625 0.485823389205113 2324 1560000
SGTC_2851 9015922 71.43 µM 0.0354679755956609 0.483049216467143 no 1626 0.485853291036585 2327 2996893
SGTC_248 streptozotocin 5.23457 mM 0.0347291171239062 0.483351529629219 no 1627 0.486147871409658 2340 5300 DNA alkylating agent.
SGTC_1630 st005209 31.3 µM 0.0325099023812953 0.484259605881586 no 1628 0.487032709623301 2351 3367314
SGTC_2876 9059903 25.97 µM 0.0322340339179108 0.484372493773938 no 1629 0.487142707565864 2353 6916095
SGTC_3345 9148410 3.559 µM 0.0317979618453409 0.484550940996306 no 1630 0.487316586013895 2337 4903596
SGTC_3194 9111903 49.47 µM 0.0302756182707094 0.485173930807781 no 1631 0.487923620729194 2340 17087251
SGTC_2077 5212015 200 µM 0.0297942323311984 0.485370936342963 no 1632 0.48811557932966 2353 780900
SGTC_3227 9130768 49.47 µM 0.0285343419081129 0.485886558931817 no 1633 0.488617989145695 2351 17720899
SGTC_2551 apiole 73.87 µM 0.0278673168092981 0.486159555144366 no 1634 0.488883987861109 2349 10659 A possible DNA adduct former.
SGTC_173 1273-0061 2.693 µM 0.0275873213553922 0.486274152020492 no 1635 0.488995646955385 2317 2847414 YPL266W DIM1
SGTC_3092 9117248 49.47 µM 0.0263425619392029 0.486783622240307 no 1636 0.489492053579952 2370 17141857
SGTC_947 3447-0010 211 µM 0.0261122441740062 0.486877891876219 no 1637 0.489583905477392 2352 748350
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0251798421585756 0.4872595337854 no 1638 0.489955757742854 2353 688664
SGTC_2251 lansoprazole 556 µM 0.0249184533346415 0.487366525077323 no 1639 0.490060004085724 2314 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2539 epi(13)torulosol 80 µM 0.0247513886038005 0.487434908245906 no 1640 0.490126632719793 2339 6708597
SGTC_363 0455-0021 3.06 µM 0.024129645262183 0.487689404327203 no 1641 0.490374598351514 2365 4597466
SGTC_3298 9116858 71.43 µM 0.0233864083465072 0.487993637528108 no 1642 0.490671023305286 2351 2506942
SGTC_402 epigallocatechin gallate 10 µM 0.02323408314971 0.488055990496208 no 1643 0.490731775758901 2327 65064 An antioxidant.
SGTC_2332 7982454 138.89 µM 0.0232115186282664 0.488065227107764 no 1644 0.490740775273502 2358 2981748
SGTC_345 1362-0200 395 µM 0.0228428124720075 0.488216155011778 no 1645 0.490887828754697 2341 1419823
SGTC_989 1501-0895 10.3 µM 0.0208244876378768 0.489042374880285 no 1646 0.491692831831328 2373 2830112
SGTC_3254 9136651 49.47 µM 0.0206875129629917 0.48909844846948 no 1647 0.491747465050863 2370 16454030
SGTC_2805 7950783 58.44 µM 0.0201750185398996 0.489308251211086 no 1648 0.491951878073274 2344 1178958 YDL195W SEC31
SGTC_1610 st001799 48.1 µM 0.0197137582085872 0.489497082493922 no 1649 0.492135857724851 2365 621897
SGTC_61 0978-8327 98.565 µM 0.0196996485545075 0.489502858757596 no 1650 0.49214148556952 2372 6150059 YHR072W ERG7
SGTC_1863 st057641 20.1 µM 0.0188985693606099 0.489830811168727 no 1651 0.492461010411423 2377 3921635
SGTC_2283 7944793 200 µM 0.0188644949556793 0.489844760983817 no 1652 0.492474601709281 2360 2970533
SGTC_2191 5911152 200 µM 0.017879295697591 0.49024809974232 no 1653 0.492867573007345 2371 2875902
SGTC_2141 5621638 7.665 µM 0.0165546455138633 0.490790424726915 no 1654 0.493395953615579 2371 2856238
SGTC_3143 9086658 49.47 µM 0.0158057273373452 0.491097046889199 no 1655 0.493694689626904 2347 25236626
SGTC_794 k038-0031 316 µM 0.0149751502904964 0.491437107980257 no 1656 0.494026002677844 2377 6624242
SGTC_2294 7971431 200 µM 0.0145180096760935 0.491624276594367 no 1657 0.494208355566975 2368 5741572
SGTC_839 0122-0028 230 µM 0.0143399357179324 0.491697186513342 no 1658 0.494279389402991 2375 759448
SGTC_158 k038-0087 26.446 µM 0.0137214420091216 0.491950422346479 no 1659 0.494526108403891 2350 X158
SGTC_2381 9035592 200 µM 0.0135929758603896 0.492003021888739 no 1660 0.494577354202796 2348 4749657
SGTC_2379 9035213 200 µM 0.0133913168559732 0.492085590000374 no 1661 0.494657797183571 2396 646551
SGTC_1587 estradiol valerate 56.1 µM 0.013362776565212 0.492097275684636 no 1662 0.494669182093567 2380 13791 A steroid.
SGTC_2820 7989630 71.43 µM 0.0130188750788543 0.492238085018233 no 1663 0.49480636700063 2384 2984098
SGTC_2874 9043904 71.43 µM 0.0112645549962585 0.49295640029023 no 1664 0.495506187779074 2340 4463428
SGTC_3114 9122766 49.47 µM 0.00988569277301818 0.493520998581788 no 1665 0.496056243417087 2356 17176985
SGTC_1294 1000-1494 117 µM 0.00825889400389427 0.49418713525829 no 1666 0.496705215448376 2388 712797 YDL207W GLE1
SGTC_3034 9090421 49.47 µM 0.0080748816114034 0.494262485155397 no 1667 0.496778623323633 2382 17173761
SGTC_1716 st033144 30.6155 µM 0.00786207824385946 0.494349624714691 no 1668 0.496863516888926 2391 674617
SGTC_792 4534-1957 155 µM 0.00433715122542208 0.49579306176695 no 1669 0.498269732424329 2375 1717904
SGTC_1883 5-benzylidenerhodanine 20 µM 0.00303542970542402 0.496326124066547 no 1670 0.498789040610917 2402 1273210
SGTC_833 3852-0053 558 µM 0.00117216856088951 0.497089151184187 no 1671 0.499532372508389 2405 3123681
SGTC_580 1123-0028 41 µM 0 0.497569173481586 no 1672 0.5 2406 1677248 YPR107C YTH1
SGTC_2226 7298446 200 µM -0.00337802529858818 0.498952547627038 no 1673 0.498652365447117 2412 3283010
SGTC_1510 1123-0200 71.5 µM -0.00348557151049644 0.498996590413146 no 1674 0.498609460968759 2414 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3210 9128157 49.47 µM -0.00406362143019658 0.499233316092383 no 1675 0.498378854061619 2432 17590849
SGTC_3051 9093778 49.47 µM -0.00436566818934688 0.499357011792196 no 1676 0.498258355909417 2412 17217378
SGTC_3322 9139058 2.11 µM -0.00512932941356254 0.499669750405685 no 1677 0.497953702599848 2459 4908926 YPR165W RHO1
SGTC_829 1635-0120 117 µM -0.00551284725147208 0.499826810762713 no 1678 0.497800703285981 2420 285054
SGTC_1943 st076331 65.2 µM -0.00635865139359906 0.499826810762713 no 1679 0.497463282207056 2414 24208415
SGTC_3354 9151612 71.43 µM -0.00644275751887713 0.499792367151582 no 1680 0.497429729404972 2416 27261949
SGTC_2389 9091542 195.52 µM -0.00645168549570719 0.499788710916631 no 1681 0.49742616773156 2427 3626624 YOL127W RPL25
SGTC_1372 2752-0194 270 µM -0.00647875594881307 0.499777624873545 no 1682 0.49741536840897 2420 823334
SGTC_1744 st037937 38.9 µM -0.0067334628561921 0.499673315888429 no 1683 0.497313757271995 2426 1016152
SGTC_1666 st014829 29 µM -0.00716839445154817 0.499495200345222 no 1684 0.497140248862508 2418 3858230
SGTC_1149 3909-7961 23.3 µM -0.00737425975962564 0.499410893301879 no 1685 0.497058122658318 2420 735261
SGTC_2756 carbadox 75.1 µM -0.00738703390453 0.499405661967723 no 1686 0.497053026650621 2425 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3264 9137442 49.47 µM -0.00745968427946118 0.499375909810887 no 1687 0.49702404414295 2421 17015726
SGTC_1762 st045503 25.4615 µM -0.00768800984763662 0.499282404768099 no 1688 0.496932958032837 2422 4645554
SGTC_3169 9102970 49.47 µM -0.00855703932436446 0.498926515821027 no 1689 0.496586276878968 2417 17027839
SGTC_3234 9132280 49.47 µM -0.00870872508519574 0.498864396850388 no 1690 0.496525765270601 2436 17612295
SGTC_1277 0873-0036 22 µM -0.00928842596710722 0.49862699565066 no 1691 0.496294507445226 2433 5965735
SGTC_675 1309-0189 238 µM -0.00960891970415061 0.498495746100791 no 1692 0.496166654650773 2426 4246530
SGTC_2254 7938975 95.19 µM -0.0099273423729767 0.49836534486216 no 1693 0.496039628446012 2433 2969277
SGTC_3193 9111931 49.47 µM -0.00994769962297378 0.4983570081166 no 1694 0.496031507479276 2437 17087244
SGTC_3030 9087619 49.47 µM -0.0106571859262314 0.498066458207273 no 1695 0.495748478422274 2424 25236973
SGTC_2110 5483698 200 µM -0.0107301237867432 0.498036588639296 no 1696 0.495719382089572 2437 2848765 YHR062C RPP1
SGTC_2012 4023501 200 µM -0.0115395576744719 0.497705109436126 no 1697 0.495396484715166 2425 3477460
SGTC_544 k015-0020 52.4 µM -0.0132642044558638 0.496998838004509 no 1698 0.49470850319067 2439 3008304
SGTC_1685 st024049 53.0905 µM -0.0136070306477476 0.49685844604916 no 1699 0.494571747672393 2459 1941139
SGTC_1865 st057639 52.2 µM -0.0137870124296896 0.496784741233495 no 1700 0.494499952065016 2432 688818
SGTC_1575 cyproterone acetate 48 µM -0.0138825670253024 0.496745610462697 no 1701 0.494461834944764 2442 9880 An androgen receptor antagonist and liver toxin.
SGTC_2125 5246583 200 µM -0.0141889967693204 0.496620123963159 no 1702 0.494339599205388 2424 835267
SGTC_2988 9073640 71.4286 µM -0.0142800120224729 0.496582852235534 no 1703 0.49430329305114 2450 9102229
SGTC_215 1287-0124 461.5 µM -0.0143092998002678 0.496570858581031 no 1704 0.494291610111969 2479 5560863
SGTC_1239 0337-0584 35.4 µM -0.014803462061917 0.496368494388858 no 1705 0.494094488779375 2434 914301 YML130C ERO1
SGTC_791 1348-1292 225 µM -0.0152921352742591 0.496168378933843 no 1706 0.493899558446507 2493 5437054
SGTC_2619 obliquin 87.91 µM -0.0153205468186695 0.496156744216125 no 1707 0.493888225207867 2440 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2158 5657123 3.6195 µM -0.0156821219195526 0.496008677079622 no 1708 0.493743994943055 2432 2858827
SGTC_1917 st066507 28.5 µM -0.0163784943767336 0.49572351001795 no 1709 0.493466218225133 2412 3156428
SGTC_286 k060-0067 22.9 µM -0.018065688820108 0.495032607085805 no 1710 0.49279322491868 2439 5985051
SGTC_456 gingerol 170 µM -0.018176976505077 0.494987035490509 no 1711 0.492748834844945 2458 442793 A herb.
SGTC_496 calpeptin 138 µM -0.0220053624541535 0.493419379793084 no 1712 0.491221838977426 2489 73364 A calpain inhibitor.
SGTC_1182 1222-0449 220 µM -0.0220965988019019 0.493382021281249 no 1713 0.491185449788932 2458 658318
SGTC_130 0136-0219 337.655 µM -0.0222082884758512 0.493336287832943 no 1714 0.491140902987317 2445 234244
SGTC_3265 9137266 49.47 µM -0.022976761766049 0.493021624324043 no 1715 0.490834404739773 2445 17224265
SGTC_35 0133-0054 64.071 µM -0.0230171253601603 0.493005096932143 no 1716 0.490818306252976 2472 99677
SGTC_975 1335-0046 28.5 µM -0.0238827360517447 0.492650664456003 no 1717 0.490473072495453 2467 16486740
SGTC_2180 6301957 200 µM -0.0243627991276951 0.492454100577118 no 1718 0.490281610753691 2450 845462
SGTC_3224 9130643 49.47 µM -0.0255085867802464 0.491984960418815 no 1719 0.489824649728421 2490 17644395
SGTC_533 1222-0222 6.71 µM -0.0258778162166 0.491833782593409 no 1720 0.489677397107666 2581 3982874
SGTC_1503 4585-0012 61.3 µM -0.0261409624348009 0.491726040346295 no 1721 0.48957245245852 2481 2922052
SGTC_1212 0520-0165 585 µM -0.0262784245065597 0.491669758293019 no 1722 0.489517631858873 2477 5403258
SGTC_1809 st050081 57.6 µM -0.0290203755091648 0.490547138325377 no 1723 0.48842417006538 2498 5036894
SGTC_323 4013-0906 34.3 µM -0.0296761807059214 0.490278646838929 no 1724 0.488162654298193 2489 2910086
SGTC_2810 7959871 45.46 µM -0.0300779805144026 0.490114149201014 no 1725 0.488002430894276 2484 2974535
SGTC_1253 0550-0034 176 µM -0.0312533795467572 0.489632948264744 no 1726 0.487533734979766 2500 5969915
SGTC_1743 st037606 46.3785 µM -0.0316314731215953 0.489478162318388 no 1727 0.487382972010243 2488 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1087 pterostilbene 9.05 µM -0.0318446417940713 0.489390894897462 no 1728 0.487297972834896 2476 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2806 7952793 58.44 µM -0.0323511906528217 0.489183524949433 no 1729 0.487095993154445 2510 2972490
SGTC_2887 9044784 58.44 µM -0.033654457633739 0.488650009720534 no 1730 0.486576347962173 2474 6465546
SGTC_2893 9048488 25.97 µM -0.0346838718613637 0.488228615234913 no 1731 0.486165910790016 2476 6467338
SGTC_920 mycophenolic acid 780.421 nM -0.0353923324627561 0.487938611897629 no 1732 0.485883449345775 2484 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2118 5526350 200 µM -0.0362299000946512 0.487595767748884 no 1733 0.485549522403108 2535 743594
SGTC_2783 7738165 71.43 µM -0.0367794595095307 0.487370819858938 no 1734 0.485330425951371 2485 17201110
SGTC_1508 1080-0625 72.9 µM -0.0371391463742043 0.487223593542777 no 1735 0.485187029626552 2448 767111
SGTC_3132 9126706 49.47 µM -0.0371575673472464 0.487216053553219 no 1736 0.485179685790556 2568 850858
SGTC_3257 9139206 32.98 µM -0.0379354445307848 0.486897660579295 no 1737 0.4848695763648 2478 4910041
SGTC_254 nsc-64875 3.808 µM -0.0381430418287094 0.486812690315638 no 1738 0.484786816922969 2490 56993
SGTC_1561 5-methoxyflavone 52.9 µM -0.0384404830797214 0.486690947667863 no 1739 0.484668241995097 2467 94525
SGTC_2402 5553605 200 µM -0.0385607674586219 0.4866417156459 no 1740 0.484620291022702 2499 6758546
SGTC_3290 9121031 71.43 µM -0.0389628829150112 0.486477132523152 no 1741 0.48445999063586 2492 17014854
SGTC_1748 st037455 53.6035 µM -0.0390305120176332 0.486449452616685 no 1742 0.484433031034543 2516 580690
SGTC_1514 1189-1591 158 µM -0.0390935288855504 0.486423660509903 no 1743 0.48440791011414 2479 767698 YMR146C TIF34
SGTC_2061 5245884 80.95 µM -0.0396184555862657 0.486208816036438 no 1744 0.484198656779912 2484 573863
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0403163824784337 0.485923171439103 no 1745 0.48392044653417 2465 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1513 0337-0559 19 µM -0.0407178459084424 0.485758865429514 no 1746 0.483760417207897 2498 775073
SGTC_1874 staurosporine 7.6 µM -0.0426100731277691 0.484984470987994 no 1747 0.48300618279488 2509 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3058 9093861 49.47 µM -0.0438254418764179 0.48448711072 no 1748 0.482521773439591 2508 17217477
SGTC_1608 st001473 40.5 µM -0.0438277977613854 0.484486146654238 no 1749 0.482520834479667 2487 7292267
SGTC_1445 4239-0156 97.7 µM -0.0439233899930884 0.484447028862583 no 1750 0.4824827353861 2559 4008346
SGTC_420 mitomycin C 81.9 mM -0.0444794160821327 0.484219497529731 no 1751 0.482261129661446 2484 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_909 3448-9333 149 µM -0.0452272833543668 0.483913471018785 no 1752 0.481963073762062 2497 3344074
SGTC_2394 5221648 200 µM -0.0453862617110574 0.483848418455541 no 1753 0.481899715635087 2529 788586
SGTC_2259 7964009 200 µM -0.0457143539180431 0.483714167334193 no 1754 0.481768961499158 2615 313134
SGTC_174 3553-0389 74.3 µM -0.0460303390169642 0.483584872031302 no 1755 0.481643034246077 2537 738071
SGTC_2321 7390090 138.78 µM -0.0461389991046643 0.483540410715923 no 1756 0.481599731150832 2540 649046
SGTC_3205 9113483 49.47 µM -0.0476831159762815 0.482908614473333 no 1757 0.480984395147324 2525 17018033
SGTC_3251 9135047 49.47 µM -0.0487095146489234 0.482488673260343 no 1758 0.480575396642364 2564 17682963
SGTC_3184 9108758 49.47 µM -0.0498422230445447 0.482025259008165 no 1759 0.48012405967702 2468 902885
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0502594138483768 0.481854583774322 no 1760 0.479957832964004 2486 77254
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0515771341387024 0.481315518571952 no 1761 0.47943281969895 2567 616764
SGTC_3059 1327-0034 3 µM -0.0517107116560585 0.481260875336461 no 1762 0.479379600996608 2518 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0518498716408513 0.481203948827049 no 1763 0.479324158570899 2622 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.052980899239716 0.48074129096789 no 1764 0.478873563267332 2540 75037 A free radical scavenger.
SGTC_2020 4017018 200 µM -0.0548474428880642 0.479977820126852 no 1765 0.478130001650604 2550 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1475 4092-1048 11.7 µM -0.0548528544475929 0.479975606746454 no 1766 0.478127845995831 2543 2881759
SGTC_2983 9022671 12.99 µM -0.0553770676826515 0.479761201379826 no 1767 0.477919032567767 2657 6405161
SGTC_1649 st011737 51.3 µM -0.0558112364724762 0.479583628991759 no 1768 0.477746091743585 2530 1761035
SGTC_1214 0358-0031 63.7 µM -0.0573670640320558 0.47894733852951 no 1769 0.477126399436472 2659 4301366
SGTC_1612 st002233 45.4 µM -0.0575400522849277 0.478876594400802 no 1770 0.47705750091632 2512 1035021
SGTC_2898 9056270 58.44 µM -0.0600282717112107 0.477859103409983 no 1771 0.476066558858047 2502 19154699
SGTC_2460 5552655 174.22 µM -0.0601137197017098 0.477824164257543 no 1772 0.476032531491584 2617 5401989
SGTC_691 1548-0686 185 µM -0.0603416792073258 0.477730953866598 no 1773 0.475941753598931 2537 46495133
SGTC_1301 naphtanilide LB 4.81 µM -0.0618932075029756 0.477096581888697 no 1774 0.475323938378145 2549 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0622594533625064 0.476946843680656 no 1775 0.475178108666694 2495 756377
SGTC_3081 9117243 49.47 µM -0.0629583567324956 0.476661108781398 no 1776 0.47489983250685 2640 45595589
SGTC_3276 9139060 49.47 µM -0.0632505617648848 0.476541649212526 no 1777 0.474783491441175 2509 4870619
SGTC_1957 st077035 62.4 µM -0.0640615767156491 0.47621010030587 no 1778 0.474460598156431 2536 705593
SGTC_1700 st030840 7.9285 µM -0.064967158412222 0.475839911286926 no 1779 0.474100074391454 2611 5499307
SGTC_1664 st014217 9.02 µM -0.0650040529468166 0.47582482976173 no 1780 0.474085386648572 2531 3982782
SGTC_1219 1469-0211 33.1 µM -0.0651497050224535 0.475765291323711 no 1781 0.474027402788339 2517 6822282
SGTC_2733 amorolfine 100 µM -0.065487328080368 0.475627282675274 no 1782 0.473892997702604 2551 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2592 piperlongumine 83.33 µM -0.0660289800282924 0.475405880176669 no 1783 0.473677376533775 2579 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1400 3771-8998 51.5 µM -0.06604798485576 0.475398112011472 no 1784 0.473669811219041 2552 670767
SGTC_1187 1391-0724 117 µM -0.0661297397392089 0.475364695059177 no 1785 0.473637266889624 2559 6997986
SGTC_770 0389-1121 67.2 µM -0.0665904897136383 0.475176368762312 no 1786 0.473453858525145 2694 6753108
SGTC_2411 st077133 39.94 µM -0.0667614339793153 0.475106498651735 no 1787 0.473385813052619 2800 1403142 YNL221C POP1
SGTC_2243 6634756 200 µM -0.0671333436548298 0.474954490525103 no 1788 0.473237774681918 2692 885676
SGTC_3256 9138902 49.47 µM -0.067268021956889 0.47489944527144 no 1789 0.473184166994105 2502 17228773
SGTC_2157 5649910 96.377 µM -0.0673447596003648 0.474868081539218 no 1790 0.473153622367919 2539 2858091
SGTC_2351 9026858 72.31 µM -0.0690634894899182 0.474165654122222 no 1791 0.472469541387046 2528 1409300
SGTC_2062 5245942 200 µM -0.069107569472965 0.474147640128589 no 1792 0.472451997933872 2515 1376160
SGTC_2902 5787006 60.46 µM -0.070109347174232 0.473738261890732 no 1793 0.472053313521115 2540 591003
SGTC_841 0251-0215 91.2 µM -0.07143729090226 0.473195638144053 no 1794 0.47152486578047 2590 3888614
SGTC_3233 9132340 49.47 µM -0.0726178536446468 0.472713278876429 no 1795 0.471055109537802 2533 17682950
SGTC_1373 2887-0003 58.5 µM -0.0736378320856806 0.472296564007689 no 1796 0.470649283596046 2606 776948
SGTC_1442 4112-3290 3 µM -0.0738507185814881 0.472209592480849 no 1797 0.470564584790787 2534 704353
SGTC_1622 st003707 19.4 µM -0.0740376725522664 0.472133216383711 no 1798 0.470490204571678 2639 10140899
SGTC_2270 7924575 90.91 µM -0.076004762828678 0.471329665837072 no 1799 0.469707654485907 2691 1262135
SGTC_2528 xanthyletin 44.79 µM -0.0773400093873023 0.470784287870622 no 1800 0.469176531658732 2569 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3068 9116768 49.47 µM -0.078852561140755 0.47016655630189 no 1801 0.468574948207914 2616 41904888
SGTC_2835 9006588 71.43 µM -0.0790838083923432 0.470072120383619 no 1802 0.468482981101994 2747 2345538
SGTC_609 0986-0026 86.3 µM -0.0797219600889889 0.46981152304429 no 1803 0.468229196707737 2546 2848610
SGTC_2363 9053361 176 µM -0.0807416064228737 0.469395164412267 no 1804 0.467823723836667 2619 6469797 YMR079W SEC14
SGTC_2091 4-phenylthiadiazole 200 µM -0.0813669015396826 0.469139850229494 no 1805 0.467575085275649 2584 270010
SGTC_59 0330-0160 1.33 µM -0.0814117924192341 0.469121521326182 no 1806 0.467557235623869 2570 4293482
SGTC_57 miconazole 162.5 nM -0.0824261804907934 0.468707365164852 no 1807 0.467153908929904 2522 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2868 9035608 32.47 µM -0.0825445303896024 0.468659047255422 no 1808 0.46710685449927 2520 6462614
SGTC_2396 5342950 42.78 µM -0.0842778321860804 0.467951457160378 no 1809 0.466417768520289 2604 1886677
SGTC_2780 5215298 71.43 µM -0.0850242192750895 0.467646788761074 no 1810 0.466121068113788 2582 2834131
SGTC_2300 7976697 71.57 µM -0.0850324089366499 0.467643445920737 no 1811 0.46611781270084 2585 2236109
SGTC_3267 9137951 49.47 µM -0.0855155533314075 0.467446241015102 no 1812 0.465925765497194 2543 16643986
SGTC_464 bw-b 70c 158 µM -0.0857520897727539 0.467349696915653 no 1813 0.46583174647074 2676 5353454
SGTC_1607 st000305 50.6 µM -0.0858426748408122 0.467312724457899 no 1814 0.465795741022795 2641 5457690
SGTC_2694 st077685 81.9 µM -0.0861584665628647 0.467183835708249 no 1815 0.4656702233833 2562 2838096
SGTC_459 nigericin 15.3 µM -0.0865387041763191 0.467028648269901 no 1816 0.465519094987687 2640 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_810 3825-7150 143 µM -0.0876487014780016 0.466575650729733 no 1817 0.465077946457142 2571 22330411 YGL099W LSG1
SGTC_137 0438-0332 85.389 µM -0.0882068746505128 0.466347872738266 no 1818 0.46485612671822 2552 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2854 9024559 71.43 µM -0.0883113809444328 0.46630522727915 no 1819 0.464814596806664 2622 3163529
SGTC_3148 9097893 49.47 µM -0.0883825369509608 0.46627619115777 no 1820 0.46478632023471 2595 17174100
SGTC_3337 9144342 33.5465 µM -0.0894655729252996 0.465834266681415 no 1821 0.464355956331086 2659 17682949
SGTC_1307 1187-1599 12.2 µM -0.0896236061090335 0.46576978596867 no 1822 0.46429316246571 2566 1538471
SGTC_3237 9133362 49.47 µM -0.0896824867735827 0.465745761704723 no 1823 0.464269766692052 2565 43845137
SGTC_919 tnp00227 403.569 nM -0.0897663327148366 0.465711551419361 no 1824 0.464236451373296 2610 1269246 A methoxyflavone. YNL221C POP1
SGTC_2764 methyldopa 94.69 µM -0.0902987572676491 0.465494320877921 no 1825 0.464024903837623 2623 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_970 1315-0089 19.5 µM -0.0963165910534343 0.463039759951401 no 1826 0.461634567296321 2572 6811083 YLR033W RSC58
SGTC_993 3909-8757 62.7 µM -0.0964468646029323 0.462986639044535 no 1827 0.461582836503298 2627 4288324 YLR208W SEC13
SGTC_403 arphamenine a 50 µM -0.0968177400002722 0.462835412903349 no 1828 0.461435567817909 2588 5487158 An arginine aminopeptidase inhibitor.
SGTC_961 1252-1571 372 µM -0.0969310410759848 0.462789214941088 no 1829 0.461390578827383 2638 6813498
SGTC_3073 9114972 49.47 µM -0.0975528547415964 0.462535682397172 no 1830 0.461143681165229 2597 41905075
SGTC_480 am 92016 50 µM -0.0997936253240896 0.461622178336147 no 1831 0.460254084521053 2649 2129 K+ channel blocker.
SGTC_2036 5160441 105 µM -0.100396131276884 0.461376586616239 no 1832 0.460014920522037 2608 134534 YIL048W NEO1
SGTC_1173 0443-0020 122 µM -0.101199594240276 0.461049104317851 no 1833 0.459696009407667 2609 5331295
SGTC_1148 3909-7663 27.7 µM -0.102081276650583 0.460689771071762 no 1834 0.459346081219129 2735 4084526
SGTC_2174 5790901 200 µM -0.103874529585648 0.45995902289593 no 1835 0.458634460094326 2647 786020
SGTC_1534 6-azauridine 81.6 µM -0.104420428410185 0.459736596589947 no 1836 0.458417855886444 2569 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2352 9027995 87.8 µM -0.105178056768579 0.459427922045602 no 1837 0.458117261147424 2640 2997347
SGTC_2640 pentamidine 10.38 µM -0.106385047888325 0.458936217767152 no 1838 0.457638427903923 2657 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_107 0358-0022 2.6945 µM -0.106570547453552 0.45886065446817 no 1839 0.457564842606468 2679 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2004 4023728 41.89 µM -0.106627238328528 0.458837561721058 no 1840 0.457542354353844 2636 360084 YDR527W RBA50
SGTC_846 0335-0850 148 µM -0.107108206773705 0.458641647203512 no 1841 0.457351568280094 2604 6819598
SGTC_417 st075190 100 µM -0.107290715973124 0.45856730773535 no 1842 0.457279174804249 2593 222757
SGTC_1814 st052110 31.539 µM -0.10875664594805 0.457970259356913 no 1843 0.456697755648213 2631 674163
SGTC_512 prima-1 270 µM -0.108903417095346 0.457910487161752 no 1844 0.456639548158796 2752 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2720 fluspirilene 36.88 µM -0.10910050563256 0.457830224828653 no 1845 0.456561386923942 2672 3396 An atypical antipsychotic.
SGTC_2994 9053520 71.4286 µM -0.109845718581521 0.457526759888988 no 1846 0.456265866107888 2687 4647384
SGTC_2289 7946404 165.07 µM -0.110458069095067 0.457277417594442 no 1847 0.456023051169054 2620 1246120 YPR165W RHO1
SGTC_2401 5128683 200 µM -0.111260365981408 0.456950756722037 no 1848 0.455704941791223 2631 708373
SGTC_1038 k292-0204 154 µM -0.113697812272522 0.455958512489162 no 1849 0.454738673414957 2586 4454212
SGTC_1989 st071868 50.2 µM -0.114200694535511 0.45575383137339 no 1850 0.454539350676301 2667 16414057
SGTC_2948 9070189 9.45 µM -0.114568797928724 0.455604014851521 no 1851 0.454393456230734 2674 6473636 YDL196W YDL196W
SGTC_1676 st018489 23.4 µM -0.116633330879448 0.454763876277946 no 1852 0.453575311875555 2679 3696235
SGTC_176 1486-1328 72.834 µM -0.1170343909807 0.454600692710256 no 1853 0.453416400338103 2681 22310231
SGTC_1496 4469-0713 57.4 µM -0.117480639149828 0.454419132001627 no 1854 0.453239592757414 2599 746691
SGTC_453 enantio-paf c16 10 µM -0.117568231954529 0.454383495074968 no 1855 0.453204888779195 2643 13871343 A lipid and platelet activating factor
SGTC_2522 biochanin a 4.94 µM -0.117961704914678 0.454223416059793 no 1856 0.453049000511834 2712 5280373 A possible chelator.
SGTC_324 1315-0088 19.6 µM -0.119949155547542 0.453414963500581 no 1857 0.452261712522342 2650 6787421
SGTC_1211 1056-0033 32.3 µM -0.120055754395788 0.453371606785441 no 1858 0.45221949084041 2637 6741922
SGTC_2405 ticlatone 3.52 µM -0.121412444374641 0.45281985197807 no 1859 0.451682180306454 2574 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2461 5755302 26.15 µM -0.122512871437805 0.452372384070161 no 1860 0.451246426423726 2788 2788904
SGTC_134 0269-0018 6.916 µM -0.122630369297097 0.452324609346077 no 1861 0.451199902359926 2717 4378915
SGTC_2017 5132927 60.65 µM -0.123957911632785 0.45178487768557 no 1862 0.450674299811459 2647 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_189 3970-0742 2.116 µM -0.124085507408964 0.451733006443424 no 1863 0.450623786442039 2631 2891807
SGTC_3121 9125696 49.47 µM -0.124976740973599 0.451370718166967 no 1864 0.450270981982481 2585 1235365
SGTC_1634 st006576 41 µM -0.124982100232427 0.451368539739438 no 1865 0.450268860580406 2689 3915356
SGTC_1072 oxiconazole 14.9 nM -0.125222425932506 0.451270853834577 no 1866 0.450173731827924 2631 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_268 camptothecin 39.6153 µM -0.126415692651758 0.450785866964128 no 1867 0.449701440432691 2626 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1058 3448-5425 97.3 µM -0.1278383116119 0.450207759090096 no 1868 0.449138465255728 2615 7279705
SGTC_3353 9151644 39.2805 µM -0.128617418921534 0.449891198924814 no 1869 0.448830191243165 2731 4909158
SGTC_1965 Pectolinarigenin 58.4 µM -0.128728239710107 0.449846173762803 no 1870 0.44878634462921 2651 5320438 An anti-inflammatory.
SGTC_962 1254-0300 21.5 µM -0.128787778400725 0.449821984170909 no 1871 0.44876278820631 2627 7340576
SGTC_3019 9081971 49.47 µM -0.129372716922796 0.449584343186489 no 1872 0.448531367487196 2739 16451803
SGTC_3098 9119039 49.47 µM -0.129379780116072 0.449581473757282 no 1873 0.448528573164879 2609 17161528
SGTC_769 0302-0231 76 µM -0.129780381633441 0.44941873331693 no 1874 0.448370092408909 2704 571869 YER009W NTF2
SGTC_2006 4011487 200 µM -0.12988598660866 0.449375833746627 no 1875 0.448328315714982 2743 45595294
SGTC_1733 st037357 54.9 µM -0.132137495064318 0.448461352281041 no 1876 0.447437769573729 2634 1272339 YGL099W LSG1
SGTC_1137 ixabepilone 100 µM -0.132440080148248 0.448338473905078 no 1877 0.447318107249845 2623 154225 A novel microtubule stabilizer.
SGTC_1876 myriocin 605 nM -0.133104258814655 0.44806877147607 no 1878 0.447055463536025 2708 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2585 alliin 100 µM -0.13330401809103 0.447987660097453 no 1879 0.446976474992963 2775 87310 A garlic compound which reacts with lipids.
SGTC_908 3448-7491 47.7 µM -0.133696568838376 0.447828272925798 no 1880 0.446821259237808 2660 1203031
SGTC_1140 3229-1848 2.98 µM -0.134363539056293 0.447557482689687 no 1881 0.446557555883081 2735 2849525
SGTC_668 1682-0499 62.6 µM -0.134887198447409 0.447344893841276 no 1882 0.446350530602 2682 682214
SGTC_3099 9120367 49.47 µM -0.135501004747051 0.447095727512379 no 1883 0.446107884955476 2638 24824940
SGTC_379 3970-0972 5.9 µM -0.136053327705616 0.446871537355396 no 1884 0.445889561723543 2703 2898042 YBL034C STU1
SGTC_1886 st057356 49.9 µM -0.136086006895349 0.446858273269357 no 1885 0.445876644746896 2633 24207747
SGTC_755 1995-0008 37.3 µM -0.13630594360151 0.446769005179828 no 1886 0.445789712712574 2640 689533
SGTC_1351 1496-0003 46.5 µM -0.136952248801806 0.446506697923579 no 1887 0.445534269651148 2746 3891978
SGTC_2830 7992007 71.43 µM -0.138955097068397 0.445693977805349 no 1888 0.444742816035411 2590 1952075
SGTC_2808 7946468 45.46 µM -0.13989583768614 0.445312320571166 no 1889 0.444371144997476 2720 2970879
SGTC_2412 st077135 33.4 µM -0.139986380558038 0.445275590114886 no 1890 0.444335375583479 2947 13258915
SGTC_1878 temozolomide 1 mM -0.140342459512359 0.445131144402497 no 1891 0.444194709213339 2650 5394 DNA alkylating agent.
SGTC_1591 genipin 88.4 µM -0.141319474936551 0.444734849298488 no 1892 0.443808782617036 2809 442424 A DNA cross-linking agent.
SGTC_2732 terfenadine 20 µM -0.141408760227568 0.444698636320164 no 1893 0.443773517075749 2648 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1018 4259-0013 28.1 µM -0.142790816446518 0.44413815095003 no 1894 0.443227695085825 2808 6801262
SGTC_2759 disulfiram 3.38 µM -0.143611384488963 0.443805426827389 no 1895 0.442903675165351 2664 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2296 7971656 126.45 µM -0.144093977752839 0.443609763279157 no 1896 0.442713130076115 2724 666570
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.145270811490132 0.443132683256008 no 1897 0.442248529644105 2727 688662
SGTC_666 0272-0154 136 µM -0.146020453557814 0.442828826629202 no 1898 0.441952620941896 2709 6870312
SGTC_2676 harmalol 100 µM -0.146024844203031 0.442827047043201 no 1899 0.441950887903181 2672 5459187 A monoamine oxidase inhibitor
SGTC_99 0109-0120 622.8 µM -0.14608090411965 0.442804325326299 no 1900 0.441928760499985 2681 759414
SGTC_2064 5220758 200 µM -0.146534374246533 0.442620535687429 no 1901 0.441749778025921 2805 788518
SGTC_594 1487-1584 10.8 µM -0.146855052955886 0.442490573332891 no 1902 0.441623214861181 2700 5013332
SGTC_2713 st079149 53.4 µM -0.149319378651989 0.441492056724068 no 1903 0.440650812369014 2743 3103253
SGTC_1134 3477-0009 42.5 µM -0.149407982927431 0.441456162169648 no 1904 0.440615856484503 2920 3973534
SGTC_2196 6573537 42.6665 µM -0.150826914048868 0.440881403463472 no 1905 0.44005612739586 2757 2903087
SGTC_3300 9124615 50.48 µM -0.151858072427519 0.440463795799166 no 1906 0.439649439017464 2846 24824903
SGTC_2688 kanamycin b 96.69 µM -0.152843260685894 0.440064867363644 no 1907 0.439260940710213 2775 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2960 9079389 5.97 µM -0.153134067872167 0.439947123556327 no 1908 0.439146275214702 2772 16457355
SGTC_3325 9138760 55.175 µM -0.153407666746021 0.43983635200541 no 1909 0.439038399631671 2707 43844959
SGTC_1374 2889-5571 141 µM -0.15388215297961 0.439644258672345 no 1910 0.438851328171531 2737 2853281
SGTC_2479 5617353 43.85 µM -0.154050480324306 0.439576115617075 no 1911 0.438784966529041 2810 2731746
SGTC_1261 0712-0010 12.7 µM -0.154430826327131 0.439422148782464 no 1912 0.438635024650363 2776 2840123
SGTC_2659 sanguinarine 24.21 µM -0.154577261183728 0.439362873326831 no 1913 0.438577298725278 2669 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1720 st037298 9.481 µM -0.154934164647498 0.439218407851855 no 1914 0.438436609675847 2773 597396
SGTC_75 0159-0059 199.013 µM -0.155161434461898 0.439126419009559 no 1915 0.438347025430087 2971 5377270
SGTC_2337 9009472 200 µM -0.155579315264542 0.438957287791166 no 1916 0.438182315205764 2791 5742383
SGTC_1679 SEC14.276 6.7 µM -0.157425570705386 0.438210176375242 no 1917 0.437454731099951 2845 1005053 YMR079W SEC14
SGTC_513 4245-1575 41.7 µM -0.157996781764856 0.437979072820231 no 1918 0.437229667322216 2815 719745
SGTC_1420 4'-methoxyflavone 42 µM -0.158212395425715 0.437891844213442 no 1919 0.437144718317365 2680 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_758 0868-0029 16 µM -0.159022676360658 0.437564064183592 no 1920 0.436825504006031 2828 762687
SGTC_2126 5251174 33.877 µM -0.159716446034639 0.437283450070769 no 1921 0.436552222576313 2788 790722
SGTC_2641 levomentholum 100 µM -0.161810250738698 0.436436745347615 no 1922 0.435727640252226 2698 16666
SGTC_670 4204-0025 119 µM -0.16199841452132 0.436360668802096 no 1923 0.435653551203818 2808 719039
SGTC_1380 2291-0730 164 µM -0.162062525919426 0.436334748444409 no 1924 0.435628308006767 2770 2999191
SGTC_1223 0764-0573 147 µM -0.162571191504646 0.436129103699386 no 1925 0.435428035520199 2696 1609797
SGTC_181 1447-1644 8.07 µM -0.163770211003824 0.435644429154516 no 1926 0.434956021595148 2747 534600
SGTC_949 1165-0505 146 µM -0.164533778892721 0.435335825684051 no 1927 0.434655478683939 2719 6244267
SGTC_2021 4019055 173 µM -0.164625581764479 0.435298725298918 no 1928 0.434619347301376 2797 44827708 YER133W GLC7
SGTC_355 1311-2252 105 µM -0.165065445073487 0.435120970813518 no 1929 0.434446235358375 2725 5338538
SGTC_1570 verbenone 133 µM -0.165685039054415 0.434870607073913 no 1930 0.434202410210841 2839 29025 A natural terpanoid with antifungal properties.
SGTC_929 2805-0021 398 µM -0.165754156269243 0.434842680007192 no 1931 0.434175212472978 2801 3098024
SGTC_1493 4348-0038 111 µM -0.166458240615408 0.43455821066467 no 1932 0.433898171899253 2715 800424
SGTC_2348 9022543 33.42 µM -0.166917421843398 0.434372707125814 no 1933 0.433717512406121 2827 3162678 YDL140C RPO21
SGTC_3067 9117431 49.47 µM -0.167513384006506 0.434131967332403 no 1934 0.433483058703723 2750 17150885
SGTC_765 1319-0117 244 µM -0.167588120747418 0.434101779037753 no 1935 0.433453658645442 2710 3487746 YGL099W LSG1
SGTC_1881 5652484 16 µM -0.17243354043391 0.432145404271583 no 1936 0.431548352809017 2808 2255129
SGTC_1636 st007707 68.9 µM -0.172732192375975 0.432024875206588 no 1937 0.431430969131779 2845 403051
SGTC_2990 9074105 71.4286 µM -0.174569764096353 0.431283413098368 no 1938 0.430708854236444 2713 6502001
SGTC_3160 9100216 49.47 µM -0.176588038111936 0.430469316474707 no 1939 0.429915995312213 2671 17191039
SGTC_1085 doxorubicin 7.67 µM -0.176722812674178 0.430414963916798 no 1940 0.429863060490928 2811 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2220 6782180 200 µM -0.177338253746505 0.430166782540764 no 1941 0.429621352403395 2716 833803
SGTC_31 0508-1974 57.237 µM -0.177397739861105 0.430142795765131 no 1942 0.429597991246514 2776 6810525
SGTC_845 0330-0138 4.51 µM -0.178212838358023 0.429814147005062 no 1943 0.429277913782794 2803 9039800
SGTC_1778 st046819 58.9 µM -0.178771119998291 0.429589075176775 no 1944 0.42905871142144 2742 671715
SGTC_2584 androsterone 48.74 µM -0.179968300355061 0.42910650790447 no 1945 0.428588727243239 2812 2754130 A steroid.
SGTC_747 3448-8087 38.7 µM -0.182787124356864 0.427970697549505 no 1946 0.427482525840465 2787 5168703
SGTC_1879 gemcitabine 100 µM -0.182930673720679 0.427912871988448 no 1947 0.427426207415129 2744 60750 A nucleoside analog which inhibits DNA replication.
SGTC_256 clotrimazole 625 nM -0.183041531110098 0.42786821669708 no 1948 0.427382715976537 2719 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_809 3998-0021 90 µM -0.183079867095084 0.427852774508165 no 1949 0.427367676254034 2813 715485
SGTC_1335 1486-0900 202 µM -0.185108798169783 0.427035655295391 no 1950 0.426571850461258 2705 X1335
SGTC_180 1486-1293 102.781 µM -0.185489446521008 0.426882390082659 no 1951 0.42642257854787 2788 4140536
SGTC_348 k064-0012 10.7 µM -0.186919807878536 0.426306564629895 no 1952 0.425861754233247 2701 5066323
SGTC_2002 4023503 131 µM -0.186924318481283 0.426304749028945 no 1953 0.425859985926711 2780 4736863 YCR052W RSC6
SGTC_295 k015-0027 31 µM -0.187803406126753 0.425950929869724 no 1954 0.425515382788655 2838 3887424
SGTC_511 blebbistatin 171 µM -0.188590504785349 0.42563418541912 no 1955 0.425206887677588 2880 3476986 A myosin inhibitor.
SGTC_602 3130-1533 38.1 µM -0.189290301579464 0.425352613295928 no 1956 0.424932648069063 2867 720941
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.189889727651725 0.42511145687136 no 1957 0.424697771082245 2739 2724 A muscle relaxant with antifungal properties.
SGTC_1061 3448-9325 110 µM -0.190488062615327 0.424870767356116 no 1958 0.424463348291894 2691 723482
SGTC_821 1114-0266 29.2 µM -0.19356496168789 0.423633481210757 no 1959 0.423258267886251 2827 3123235
SGTC_1100 amiodarone 5.07 µM -0.195155093631368 0.422994349724439 no 1960 0.422635766577757 2853 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1101 ebselen 5.29 µM -0.195190374342152 0.422980171423436 no 1961 0.422621957148387 2886 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2692 st077426 47.7 µM -0.195761187782317 0.422750791826842 no 1962 0.422398544948598 2881 25238571
SGTC_1330 1469-0054 61.8 µM -0.197951959563485 0.421870680840804 no 1963 0.421541325294587 2912 7102664
SGTC_3343 9148379 18.9835 µM -0.199563798961586 0.421223396410905 no 1964 0.420910871225302 2907 1955036
SGTC_2847 9005661 71.43 µM -0.20043233361758 0.420874697341072 no 1965 0.420571236972509 2753 2991449
SGTC_1825 st052143 62.6 µM -0.2010193789078 0.420639045685515 no 1966 0.420341710587425 2924 674173
SGTC_1447 4239-0816 81.9 µM -0.201414708834156 0.420480368408063 no 1967 0.420187157447638 2765 1341554
SGTC_2928 9011484 9.79 µM -0.202412254433301 0.42008003167621 no 1968 0.419797224513285 2888 2994751
SGTC_374 0880-0231 82.3 µM -0.202871492035963 0.41989575741072 no 1969 0.419617738493093 2835 6833587
SGTC_2977 9011197 71.43 µM -0.20395695165377 0.419460274379811 no 1970 0.419193569674067 2997 2704722
SGTC_2563 tomatine 8.54 µM -0.205630864281764 0.418788899329772 no 1971 0.418539633248115 2778 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_204 PMA1.184 62.41 µM -0.206009864146403 0.418636922332075 no 1972 0.418391603049473 2731 2252213 YGL008C PMA1
SGTC_2942 9052777 62.25 µM -0.206059163306393 0.418617154514348 no 1973 0.418372348576452 2805 6469503
SGTC_2681 menadione 3.18 µM -0.207080344029271 0.418207731060164 no 1974 0.417973556287653 2828 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3301 9125354 19.7965 µM -0.207300400690671 0.418119515016713 no 1975 0.417887630618987 2754 41905162
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.208622606984623 0.417589557464464 no 1976 0.417371430530521 2765 15053
SGTC_321 4534-3890 65.3 µM -0.209479306558294 0.417246260915953 no 1977 0.417037044004428 2899 699746
SGTC_188 3229-0966 278.469 µM -0.211104884827914 0.416595032990908 no 1978 0.416402714293212 2823 5722370
SGTC_255 tunicamycin 200.472 nM -0.21142192400427 0.416468049561247 no 1979 0.416279025249908 2873 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_928 2764-0428 58.7 µM -0.211919991153683 0.416268576761776 no 1980 0.416084727055042 2901 662578
SGTC_2089 5281248 129.67 µM -0.212387932940835 0.416081188628622 no 1981 0.415902199580335 2781 2737878
SGTC_2328 6201408 200 µM -0.213291385186492 0.415719453549497 no 1982 0.415549846293557 2892 2890418
SGTC_3215 9129942 49.47 µM -0.213633135761111 0.415582637940093 no 1983 0.41541657863839 2882 17682944
SGTC_1741 st038134 10.228 µM -0.214360880585746 0.415291328430648 no 1984 0.415132822682889 2994 1272587
SGTC_1246 0422-0085 105 µM -0.214407037097234 0.415272853975268 no 1985 0.415114827227083 2898 264295
SGTC_1365 1672-3266 55.4 µM -0.214827082438175 0.415104736605488 no 1986 0.41495106854742 2893 6415873
SGTC_2827 7993847 71.43 µM -0.215171883137706 0.41496674648346 no 1987 0.414816655750215 2903 2985692
SGTC_3230 9131665 49.47 µM -0.215245763262847 0.41493718083247 no 1988 0.414787856541921 2775 15943720
SGTC_26 0302-0163 425.158 µM -0.217887185807142 0.41388044330674 no 1989 0.413758505769632 2794 3100915
SGTC_2366 9070441 60.58 µM -0.219283634359083 0.413322026171866 no 1990 0.413214554784104 2807 6837235
SGTC_2175 5807670 165.306 µM -0.219734541027646 0.413141753290318 no 1991 0.413038951090756 2901 241186
SGTC_1017 4239-0030 168 µM -0.21977088539913 0.41312722357573 no 1992 0.413024797686353 2814 1149593
SGTC_1077 5-fluorocytosine 377 nM -0.219858364463921 0.413092251775179 no 1993 0.412990731621028 2870 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1499 4480-0877 67.3 µM -0.219868782668114 0.413088086900529 no 1994 0.412986674611429 2783 2861909
SGTC_1646 st011709 75.6 µM -0.221559825906853 0.41241219027829 no 1995 0.412328279733418 2867 5757843
SGTC_56 0957-0365 83.25 µM -0.222605823699122 0.41199424307759 no 1996 0.411921151760049 2857 6752360
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.224985877149843 0.411043622611917 no 1997 0.410995130516153 3041 6710655
SGTC_827 3253-0474 693 µM -0.22533226435038 0.410905315012102 no 1998 0.410860400838324 2920 5402065
SGTC_2754 granisetron 64.02 µM -0.226115578260459 0.410592589511436 no 1999 0.410555764320606 2943 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3023 9089636 49.47 µM -0.226275470957549 0.410528761897461 no 2000 0.410493587504107 2832 17249241
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.226398589235274 0.410479615889697 no 2001 0.410445712537909 2794 3256 An antibiotic and ribosome inhibitor.
SGTC_426 0988-0037 14.6 µM -0.227906940783154 0.409877630689345 no 2002 0.409859293373852 2919 5383008
SGTC_1311 1190-0148 100 µM -0.228879909585459 0.409489430068484 no 2003 0.409481127972609 2936 1961333
SGTC_633 0437-0093 97.7 µM -0.230666822571136 0.408776708744377 no 2004 0.408786825113373 2805 2831118
SGTC_1853 st056710 91.2 µM -0.231210907818844 0.408559756748891 no 2005 0.408575478180398 2992 269167
SGTC_1130 3454-2858 15.9 µM -0.231557749493331 0.408421469524255 no 2006 0.408440763304495 2923 715628 YIL048W NEO1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.233010122725599 0.407842526287898 no 2007 0.407876772651008 2997 551469
SGTC_2235 salicylic acid 500 µM -0.233914310383481 0.40748220163688 no 2008 0.407525751649051 2820 338 A COX inhibitor and kinase inhibitor.
SGTC_1923 st058458 19.1 µM -0.234162713290466 0.407383225156897 no 2009 0.407429330409496 3066 3534982
SGTC_1976 st070609 63.5 µM -0.236215617807022 0.406565469444193 no 2010 0.406632680568599 2752 682556
SGTC_3335 9143315 29.6265 µM -0.237819223088837 0.405926971113846 no 2011 0.406010654245862 2870 4899691
SGTC_740 k014-0057 261 µM -0.238789988813088 0.405540568328318 no 2012 0.405634216737253 2930 4012779
SGTC_1556 plumbagin 1.48 µM -0.238795316377022 0.405538448002764 no 2013 0.405632151087996 2809 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.239107512167156 0.405414201551355 no 2014 0.405511108421726 2974 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2207 7258803 200 µM -0.239134387570635 0.405403506229445 no 2015 0.405500688874823 2910 3666799
SGTC_888 0916-0002 6.97 µM -0.240144742860865 0.405001477061416 no 2016 0.405109024539088 3002 2802138 YIL048W NEO1
SGTC_3326 9140064 16.379 µM -0.240634690240728 0.404806558796251 no 2017 0.404919130572316 2821 1868434
SGTC_800 3448-7362 155 µM -0.243091268868552 0.40382960260161 no 2018 0.403967347409418 2915 15991913
SGTC_2014 4013930 200 µM -0.244592852566479 0.403232733006691 no 2019 0.403385849409814 2864 64556
SGTC_109 0132-0036 33.701 µM -0.244669885270108 0.403202119081751 no 2020 0.403356023744727 2791 67274 A color developer.
SGTC_3330 9141424 71.43 µM -0.245084120870588 0.403037505962739 no 2021 0.403195648879592 2976 27261020
SGTC_697 0508-1955 564 µM -0.245449573425938 0.402892293007868 no 2022 0.403054174305626 2981 6243113
SGTC_1684 st024538 14.6195 µM -0.24570196286271 0.40279201361909 no 2023 0.402956476312857 2841 6732859
SGTC_366 0181-0206 4.31 µM -0.246067748312664 0.402646691069236 no 2024 0.402814894357437 3004 274874
SGTC_477 mead ethanolamide 10 µM -0.246427313104438 0.402503853027704 no 2025 0.40267573260726 2813 16061185
SGTC_3323 9138564 53.9225 µM -0.247471232401491 0.402089227203496 no 2026 0.402271776221424 3000 43912313 YNL103W MET4
SGTC_399 oxolinic acid 75 µM -0.247654518881734 0.402016440490557 no 2027 0.402200862200425 2834 4628 A DNA gyrase inhibitor.
SGTC_2596 sinensetin 100 µM -0.248336539496683 0.401745626382734 no 2028 0.401937014922792 2897 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_266 formosanin C 406 nM -0.249124438191996 0.401432829352397 no 2029 0.401632263164844 2960 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_967 1306-0166 352 µM -0.251495086161986 0.400492059980487 no 2030 0.400715680407279 3003 4437607
SGTC_1787 fluconazole 80 µM -0.252120586188115 0.400243932151678 no 2031 0.400473929175392 2901 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_679 0422-0091 41.4 µM -0.253654333432166 0.399635684899056 no 2032 0.399881308490093 2839 627384 YHR062C RPP1
SGTC_1190 1486-1332 13 µM -0.254522332017862 0.399291565338754 no 2033 0.39954602678731 2864 4150046
SGTC_1949 st076024 69.1 µM -0.256070102081092 0.398678143480316 no 2034 0.398948353776689 2793 2921930
SGTC_902 1120-0002 2.07 µM -0.257464871353297 0.39812557413189 no 2035 0.398409965015165 2842 3280475
SGTC_2735 sertaconazole 140 nM -0.257653253635682 0.3980509578682 no 2036 0.398337263193228 2853 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_870 0573-2213 57.6 µM -0.258196185430537 0.397835929094805 no 2037 0.398127750865983 2847 3916321
SGTC_3178 9107506 49.47 µM -0.258269370297039 0.397806946514686 no 2038 0.398099511751914 3005 8897194
SGTC_788 1182-0090 188 µM -0.25859672308611 0.3976773155744 no 2039 0.397973205933333 3056 5715185
SGTC_556 4058-0063 51.5 µM -0.259852112253084 0.397180289254458 no 2040 0.397488925739114 2906 6615692
SGTC_1764 st044502 93.5 µM -0.259913615342478 0.397155943594784 no 2041 0.397465204298112 3002 8407
SGTC_199 4063-0024 41.6 µM -0.260148407872352 0.397063005948968 no 2042 0.397374649454515 2981 306215
SGTC_2871 9038510 12.99 µM -0.262023296581655 0.396321081115888 no 2043 0.396651740706798 3057 4945164
SGTC_3110 9122132 49.47 µM -0.262115048080846 0.396284783123577 no 2044 0.39661637278775 3028 918317
SGTC_1816 st051957 91.6 µM -0.262241274705232 0.396234847827981 no 2045 0.396567716956161 2894 674121
SGTC_485 niflumic acid 177 µM -0.262274285808674 0.396221788905003 no 2046 0.396554992626681 2981 4488 A COX2 inhibitor.
SGTC_1201 1889-3372 45.9 µM -0.262413554923985 0.39616669646224 no 2047 0.396501311716807 2900 5392199
SGTC_1435 4092-0789 56.7 µM -0.264380314059413 0.395388902616818 no 2048 0.39574343956793 2974 2248285
SGTC_865 0488-0499 301 µM -0.265738256530558 0.394852120257831 no 2049 0.395220398948484 2975 9634651
SGTC_966 1300-0360 30.2 µM -0.265990798440827 0.394752314702148 no 2050 0.395123147808265 2876 70588
SGTC_976 1348-1067 47.6 µM -0.266167085222293 0.394682649566183 no 2051 0.395055265559182 2897 5310671 YGL099W LSG1
SGTC_2738 aclarubicin 5.55 µM -0.266198537653245 0.39467022052606 no 2052 0.395043154595907 2950 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3078 9116413 49.47 µM -0.266423209808975 0.394581440070759 no 2053 0.394956646069689 2798 17177322
SGTC_2105 5350118 200 µM -0.266530240622076 0.394539148173157 no 2054 0.394915436384351 2908 2133313
SGTC_2996 9066192 71.4286 µM -0.267335079284667 0.394221166012528 no 2055 0.394605589963707 2923 6472854
SGTC_1799 st045822 46.1415 µM -0.269187857246978 0.393489423763052 no 2056 0.393892562014266 3028 3674992
SGTC_329 k048-0121 21.3 µM -0.27106509180986 0.39274840602783 no 2057 0.393170484733498 2963 6832902
SGTC_525 k781-2675 26.7 µM -0.271182540082123 0.392702057500018 no 2058 0.393125320503352 2887 3651118 YDL195W SEC31
SGTC_1818 st052136 56.3 µM -0.272555972543706 0.392160173919644 no 2059 0.392597279847967 2979 674169
SGTC_515 4092-1064 102 µM -0.272648631431051 0.392123623155466 no 2060 0.392561662588711 3134 717353
SGTC_2038 4100038 30.985 µM -0.272740573621197 0.392087356044663 no 2061 0.392526321710925 2986 3596803
SGTC_2886 9058944 51.95 µM -0.274010963456224 0.391586339770376 no 2062 0.39203809818875 2924 4949929
SGTC_1242 0402-0103 60.1 µM -0.274218209721965 0.391504623033804 no 2063 0.391958467477548 2866 432868
SGTC_672 1441-0018 53.7 µM -0.275005140750157 0.391194381530889 no 2064 0.391656144392812 2880 251141
SGTC_1091 telmisartan 47.6 µM -0.276941016680818 0.390431472295671 no 2065 0.390912698542227 2989 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_147 4466-0538 29.23 µM -0.278782060183807 0.38970632669548 no 2066 0.390206041379284 3117 6742687 YHR072W ERG7
SGTC_1217 1183-1422 255 µM -0.279000360829645 0.389620368386183 no 2067 0.390122273927094 3034 2849664
SGTC_1995 st072814 61.1 µM -0.279715170591021 0.389338941891955 no 2068 0.389848019153274 2906 5769371
SGTC_1453 4237-0541 195 µM -0.281412865746132 0.388670778152909 no 2069 0.389196875625272 3024 739892
SGTC_1226 3909-7979 35.4 µM -0.282358199933308 0.388298864515876 no 2070 0.388834431542524 3010 6615510
SGTC_1275 0867-0008 21.1 µM -0.282781430501414 0.388132390193352 no 2071 0.388672194949837 2870 3422836
SGTC_3293 9120939 62.045 µM -0.283358962524015 0.387905255805673 no 2072 0.388450841448494 3054 934087
SGTC_3074 9116018 49.47 µM -0.283491519825951 0.387853128482517 no 2073 0.388400040676467 2868 17027303
SGTC_2293 7624732 200 µM -0.285632648859062 0.387011423566707 no 2074 0.38757974729727 2864 894453
SGTC_2052 5265182 7.135 µM -0.286861045062991 0.386528764946497 no 2075 0.387109359488893 3065 1239884
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.287236400807418 0.386381315998503 no 2076 0.386965658136419 2846 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1194 1488-0194 225 µM -0.287960551224751 0.386096898314425 no 2077 0.386688467875036 2881 1391452
SGTC_869 0564-0080 44.1 µM -0.288819599533637 0.385759577443652 no 2078 0.386359716364017 2956 6843321
SGTC_658 3253-0951 102 µM -0.288820815132006 0.385759100178083 no 2079 0.386359251221136 2952 1184878
SGTC_1460 k062-0059 9.15 µM -0.28907040790894 0.38566110927292 no 2080 0.386263749203082 2824 1373085
SGTC_3009 9080819 71.4286 µM -0.290273936401485 0.385188702750175 no 2081 0.385803338299448 2989 17027216
SGTC_1200 1643-0193 18.4 µM -0.290348941409661 0.385159267570244 no 2082 0.385774650383477 2998 5403974
SGTC_1545 lovastatin 49.4 µM -0.292702399773833 0.384236006561478 no 2083 0.38487481771963 2987 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1281 0884-0031 11.8 µM -0.29362459619089 0.383874407901085 no 2084 0.384522389400819 2935 1548255
SGTC_637 1181-0519 7.26 µM -0.294588162720577 0.383496695760778 no 2085 0.384154252940425 2939 6252091 YGR060W ERG25
SGTC_894 0960-0238 55.9 µM -0.295016751783595 0.383328727035542 no 2086 0.383990541432595 3008 6741907 YDL195W SEC31
SGTC_3095 9117207 49.47 µM -0.295124438166468 0.38328652701418 no 2087 0.383949410877478 3035 17015229
SGTC_3000 9075062 71.4286 µM -0.295160147485224 0.383272533591313 no 2088 0.38393577207758 2955 17057871
SGTC_2324 6149169 200 µM -0.297465281099039 0.382369543089537 no 2089 0.383055655323989 2997 2888231
SGTC_1609 st001574 46.4 µM -0.298238478960312 0.382066801055576 no 2090 0.382760577670421 2920 3960012
SGTC_221 trifluoperazine 10.304 µM -0.298596393409827 0.381926685713105 no 2091 0.382624008808708 2959 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1895 st058434 18.3 µM -0.298690875885611 0.381889700558465 no 2092 0.382587959711088 3099 5393175
SGTC_2605 digitonin 300 nM -0.298721604536563 0.381877672063764 no 2093 0.382576235638281 3064 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2481 5478948 45.16 µM -0.299011515177423 0.381764194381936 no 2094 0.382465629720498 3082 77792
SGTC_1929 genistein trimethyl ether 50.5 µM -0.299190616864702 0.381694094945328 no 2095 0.382397304123347 3123 136420
SGTC_646 4092-0839 27.3 µM -0.299658492719698 0.381510989164338 no 2096 0.382218831196372 3072 877796
SGTC_414 piperonyl butoxide 100 µM -0.299707734703157 0.381491719585583 no 2097 0.382200049119366 2935 5794 A potent inhibitor of cytochrome P450.
SGTC_2570 licareol 100 µM -0.300349384952278 0.381240653196222 no 2098 0.381955333633203 3008 443158
SGTC_3130 9127414 49.47 µM -0.300957121883678 0.381002902568249 no 2099 0.381723595644802 2954 1494646
SGTC_3162 9099653 49.47 µM -0.301561157301533 0.380766644501739 no 2100 0.381493311086682 3060 25237511
SGTC_730 1436-0052 41.2 µM -0.302896065495684 0.38024467590674 no 2101 0.380984534938376 2935 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_19 0279-0214 38.434 µM -0.304126548194818 0.379763732266478 no 2102 0.380515740833842 2950 3566274 YBR002C RER2
SGTC_805 3852-0218 479 µM -0.304233520677596 0.379721930021673 no 2103 0.380474994317366 2926 6615355
SGTC_1462 k081-0014 26.5 µM -0.304492339447515 0.379620795755983 no 2104 0.380376414045963 2955 3270634
SGTC_3279 9140807 49.47 µM -0.304876461737347 0.379470713919066 no 2105 0.380230121825083 2926 45595718
SGTC_131 0141-0277 33.849 µM -0.309458958461147 0.377681676181306 no 2106 0.378486213672823 3129 1547771
SGTC_2914 7968218 45.32 µM -0.310761397100333 0.377173671957014 no 2107 0.377991009125456 3045 2977111
SGTC_1524 corynanthine 62.1 µM -0.310805851508448 0.377156336668921 no 2108 0.37797411049867 3119 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_198 3454-2873 16.191 µM -0.311869815804824 0.376741510756028 no 2109 0.377569731354244 2974 710957
SGTC_3201 9113999 49.47 µM -0.312629223593777 0.376445514465883 no 2110 0.377281186522954 3136 16649224
SGTC_2992 9074591 71.4286 µM -0.313735081050939 0.376014611559932 no 2111 0.376861127100653 3068 17741321
SGTC_212 3807-4682 38.772 µM -0.314179613863217 0.375841440635328 no 2112 0.376692312559623 3032 3125501 YBL034C STU1
SGTC_277 nystatin 15.5 µM -0.314955557880043 0.375539226044747 no 2113 0.376397698733298 2912 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2958 9077254 16.72 µM -0.315808083517375 0.3752072724865 no 2114 0.376074091067204 3163 16457351
SGTC_3286 9117135 37.221 µM -0.316927024814675 0.374771723150075 no 2115 0.375649487711625 2986 3438150
SGTC_2911 7942208 15.64 µM -0.316937195121175 0.37476776507672 no 2116 0.375645629086893 3044 1243384
SGTC_1948 st076329 66.6 µM -0.317317483013409 0.374619774351436 no 2117 0.375501356400583 2899 24208413
SGTC_334 1502-1024 68.5 µM -0.317713838966866 0.374465550320968 no 2118 0.375351006380457 3055 3296216
SGTC_383 2324-0395 7.37 µM -0.317793900906228 0.374434400267847 no 2119 0.375320638718745 3100 3146421
SGTC_2685 mycophenolic acid 18.85 µM -0.318618300992006 0.37411369497924 no 2120 0.375007987005713 3000 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_552 k242-0005 476 µM -0.320136233817857 0.373523421956111 no 2121 0.374432529626709 3091 4088318
SGTC_2675 theaflavin digallate 100 µM -0.320422844091902 0.373412002107756 no 2122 0.374323905305463 3009 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_789 1309-1135 70.6 µM -0.321744198244266 0.372898462189516 no 2123 0.373823245694721 2942 3092424
SGTC_1097 itavastatin 7.23 µM -0.322626299895424 0.372555761916143 no 2124 0.373489136767072 3016 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1481 3346-2004 36 µM -0.323705565771883 0.372136599725286 no 2125 0.373080478342966 3029 2770522
SGTC_1932 st074806 40.9 µM -0.323952929266388 0.372040550717554 no 2126 0.372986835531512 3202 17251235
SGTC_1613 st002381 52.1 µM -0.324419917349518 0.371859245175831 no 2127 0.372810071307023 3009 551167
SGTC_735 3076-0345 636 µM -0.32455420605781 0.371807113585553 no 2128 0.372759245331084 3137 2888990
SGTC_1037 k284-1091 78.7 µM -0.326335713087199 0.371115745849265 no 2129 0.372085185370994 2946 3334711
SGTC_3299 9121982 43.1275 µM -0.327718933450556 0.370579231902538 no 2130 0.371562093235053 2997 17594604 YPL160W CDC60
SGTC_2032 5185112 25.99 µM -0.328178105676019 0.370401186927134 no 2131 0.371388500543538 3030 5718189
SGTC_58 0957-0393 9 µM -0.328185901745358 0.370398164224754 no 2132 0.371385553420572 3111 6997992
SGTC_2755 lomerizine 42.69 µM -0.328277377067941 0.370362697888779 no 2133 0.371350973862535 3018 3949 A calcium channel blocker.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.328773589165471 0.37017032832615 no 2134 0.371163413559024 2986 260807
SGTC_2181 6316240 54.2555 µM -0.329456616832354 0.369905587953486 no 2135 0.370905289984679 3063 12779990
SGTC_2058 5236698 133 µM -0.329535768263288 0.369874912975338 no 2136 0.370875381552269 3007 766665
SGTC_2463 5473429 200 µM -0.330387840621518 0.369544746509625 no 2137 0.370553463990194 3038 5399405
SGTC_2707 st078556 66.6 µM -0.330556586515492 0.369479371169281 no 2138 0.370489721618242 3054 17250899
SGTC_2576 guaiol 23.12 µM -0.331559979821144 0.369090715677555 no 2139 0.370110771540132 3084 227829
SGTC_951 1171-0579 82.7 µM -0.332540046980699 0.368711224518447 no 2140 0.369740752699503 2935 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1428 4049-0204 61.7 µM -0.332624443765952 0.368678551274969 no 2141 0.369708894802241 3098 X1428
SGTC_1695 st026914 34.495 µM -0.333976237188687 0.368155349535844 no 2142 0.369198745061598 2962 3289191
SGTC_2104 5389443 200 µM -0.334941758608792 0.367781801131558 no 2143 0.368834510409418 3171 2244536
SGTC_14 0354-0009 295 µM -0.336464552098371 0.367192905202754 no 2144 0.368260289130135 2981 1713507
SGTC_1308 1187-1617 41.4 µM -0.337572237452503 0.36676473633495 no 2145 0.367842783273177 2991 2882570
SGTC_2095 5432005 200 µM -0.33820235771422 0.366521241190691 no 2146 0.367605349619387 2999 783734
SGTC_2933 9026794 32.47 µM -0.338601145779646 0.366367166677927 no 2147 0.367455109666847 3037 17586027
SGTC_2773 thioridazine 9.09 µM -0.338874352447364 0.366261623832626 no 2148 0.367352193127095 3019 5452 An antipsychotic.
SGTC_2399 5884133 200 µM -0.339512900018423 0.36601498510244 no 2149 0.367111690389883 3005 722445
SGTC_2818 7996756 12.99 µM -0.339757079821585 0.365920685381959 no 2150 0.36701973621503 2923 2241621
SGTC_1992 st073643 23.3 µM -0.34171791743307 0.365163724244294 no 2151 0.366281593403499 2975 3161292
SGTC_1830 st055982 50.3 µM -0.341853571762349 0.365111375675291 no 2152 0.366230545592089 3127 455313 An antimicrobial agent.
SGTC_2223 6903751 107.57 µM -0.341881143239722 0.36510073623826 no 2153 0.366220170513598 3087 5598863
SGTC_2941 9056145 11.23 µM -0.343333865636877 0.364540298599456 no 2154 0.36567365317786 3035 2119517
SGTC_2421 5690543 90.72 µM -0.343367848320687 0.364527192069823 no 2155 0.365660872076081 3115 3397993
SGTC_1507 4075-3230 155 µM -0.343965181008256 0.364296837119856 no 2156 0.365436235845512 3045 659771
SGTC_1811 st050069 61.5 µM -0.34417614284489 0.364215493654786 no 2157 0.365356911395583 3061 3877702
SGTC_925 2064-1272 59.6 µM -0.345374657199235 0.363753482119435 no 2158 0.364906363491593 3027 6815817
SGTC_3138 9097216 49.47 µM -0.345587592896026 0.363671418904557 no 2159 0.364826335770495 3016 25237486
SGTC_676 falcarinol 140 µM -0.345869805680978 0.363562666654095 no 2160 0.364720280684313 3212 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1407 3909-7909 12.3 µM -0.346371931893006 0.363369196739728 no 2161 0.364531608103498 3022 4411780
SGTC_428 3448-4153 16.5 µM -0.346697317486414 0.363243843831184 no 2162 0.36440936285504 2952 3834874
SGTC_83 0170-0301 39.027 µM -0.347143434843284 0.363072003519549 no 2163 0.364241781885416 2987 3089716
SGTC_3157 9099274 49.47 µM -0.347757437845165 0.362835540275752 no 2164 0.364011178251251 3151 17217662
SGTC_1697 st025554 27.742 µM -0.348579777207513 0.362518925003134 no 2165 0.363702406013075 2998 1269519
SGTC_1745 st081495 74 µM -0.349661135028968 0.362102726117746 no 2166 0.363296512172047 3041 13842402 YBL026W LSM2
SGTC_3161 9100388 49.47 µM -0.350933969332078 0.361613039581265 no 2167 0.362818943174193 3036 25236368
SGTC_2598 perillyl alcohol 100 µM -0.351102733542111 0.361548129379816 no 2168 0.362755638633591 3182 10819 An apoptosis inducer.
SGTC_2217 6934799 96.0675 µM -0.351201301135062 0.361510220090368 no 2169 0.362718667030554 3098 675606
SGTC_2702 st077768 96.8 µM -0.353245302007108 0.360724400248712 no 2170 0.361952274051872 3101 6484119
SGTC_718 1130-0073 349 µM -0.357519761179033 0.359082979544188 no 2171 0.360351367578517 3197 6740020
SGTC_1473 k844-0725 134 µM -0.358360765312783 0.358760333293651 no 2172 0.3600366746289 3077 54682906
SGTC_1241 0364-0022 50.8 µM -0.358669970688866 0.358641733804626 no 2173 0.359920997778361 3058 4563895
SGTC_1927 st060202 13.8 µM -0.358869666998575 0.358565145095432 no 2174 0.359846296191504 3136 688887
SGTC_2442 5158906 48.48 µM -0.359284612379076 0.358406020981891 no 2175 0.359691092225319 3164 1893835
SGTC_763 3453-1109 128 µM -0.359790389350198 0.358212097828544 no 2176 0.359501945383576 3193 1560353
SGTC_738 1315-0003 72.4 µM -0.360197347476611 0.358056089982257 no 2177 0.359349779089197 3176 6251474
SGTC_1891 st059073 26.2 µM -0.360918124651325 0.357779837430642 no 2178 0.359080327013816 3200 688754
SGTC_269 exalamide 29 µM -0.361465437981292 0.357570118173369 no 2179 0.358875768685629 3051 3316 A derivative of salicylamide.
SGTC_349 k015-0014 24 µM -0.362162387763505 0.357303123538749 no 2180 0.358615342320152 2979 2196908
SGTC_2889 9059656 51.95 µM -0.362845830786975 0.357041371035027 no 2181 0.358360026796482 3133 3949838
SGTC_440 fluspirilene 35.1 µM -0.362985114534341 0.356988034866461 no 2182 0.35830800197992 3255 3396 An atypical antipsychotic.
SGTC_858 0438-0351 2.77 µM -0.363004550674462 0.356980592373592 no 2183 0.358300742464584 3079 2799119
SGTC_2520 obtusaquinone 4.71 µM -0.364009609918798 0.356595809009253 no 2184 0.357925416645399 3211 5967872
SGTC_2987 9018338 71.43 µM -0.365924470757661 0.355863115400278 no 2185 0.357210717917673 3180 5055682
SGTC_957 1187-1561 14.1 µM -0.367224707474163 0.355365901891181 no 2186 0.356725705469174 3132 1538454
SGTC_1292 0kpi-0043 232 µM -0.368954112567492 0.354704954839255 no 2187 0.356080964135149 3102 3333905
SGTC_1414 3917-0015 5.4 µM -0.369076640821381 0.354658143338296 no 2188 0.35603529982928 3150 6618702
SGTC_303 1348-1668 34.2 µM -0.369273676649995 0.354582871075661 no 2189 0.355961872081465 3095 5380509
SGTC_1363 1636-0063 10.4 µM -0.369801695631967 0.354381183566092 no 2190 0.355765125868375 3081 6072185
SGTC_1754 st042065 16.137 µM -0.369861041709269 0.354358517685216 no 2191 0.355743015207813 3137 1126236 YIL048W NEO1
SGTC_2057 5236571 38.335 µM -0.371563495142387 0.353708524354312 no 2192 0.355108936396208 3237 54684039 YBR257W POP4
SGTC_2602 kawain 100 µM -0.371876042049182 0.353589240822734 no 2193 0.354992571811984 3125 5369129
SGTC_2311 7694451 200 µM -0.372173706240583 0.353475650644524 no 2194 0.35488176079654 3091 2163142
SGTC_3011 9081274 71.4286 µM -0.372477408866075 0.353359769616882 no 2195 0.354768714513406 3061 6625322
SGTC_1926 methyl fluorone black 53.6 µM -0.372844901579651 0.353219566965687 no 2196 0.354631940943361 3074 72721 Reacts with homocysteine.
SGTC_710 3448-4187 58 µM -0.373285220386732 0.353051606564352 no 2197 0.354468087610466 3097 3946412
SGTC_2415 st077333 57.7 µM -0.37333043442883 0.353034361206769 no 2198 0.354451263890318 3299 2766255
SGTC_206 4546-0025 72.014 µM -0.374467450623949 0.352600784404671 no 2199 0.354028284291463 3138 6620745 YIL048W NEO1
SGTC_1970 st070122 35.8 µM -0.376031350285502 0.352004737515625 no 2200 0.353446794691476 3225 102928
SGTC_1474 0330-0125 5.35 µM -0.376124169659287 0.351969372809562 no 2201 0.35341229330148 3119 X1474
SGTC_1204 4049-0315 18.3 µM -0.376205537511605 0.351938372251138 no 2202 0.353382049485646 3285 588402
SGTC_1509 1326-1131 80 µM -0.376275786439704 0.351911608713398 no 2203 0.353355939234577 3168 768313
SGTC_2313 7726885 200 µM -0.377863354037495 0.351306970803132 no 2204 0.352766053435394 3146 726423
SGTC_2611 pyromycin 23.93 µM -0.378457847051148 0.351080650061505 no 2205 0.352545251142529 3085 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3192 9110362 49.47 µM -0.378942361043948 0.350896236880386 no 2206 0.35236533319753 3105 16649480
SGTC_2184 6075246 200 µM -0.379162224944082 0.350812565013942 no 2207 0.352283700501871 3130 2267320
SGTC_387 norethindrone acetate 66.7 µM -0.379850452952504 0.350550698306424 no 2208 0.3520282141196 3098 541197
SGTC_132 0417-1715 25.805 µM -0.380318715299531 0.350372567820633 no 2209 0.351854422321023 3231 6769098
SGTC_3152 9099253 49.47 µM -0.380367962535201 0.350353835716857 no 2210 0.351836146404128 3122 25236131
SGTC_2998 9066762 71.4286 µM -0.38041498658743 0.350335949582035 no 2211 0.351818695842203 3260 4945196
SGTC_3039 9090270 49.47 µM -0.38214025045562 0.349679955543982 no 2212 0.351178668860457 3225 17173750
SGTC_3321 9137793 26.8275 µM -0.383518111004526 0.349156376106808 no 2213 0.350667822154555 3154 4904192
SGTC_1885 st057546 99.9 µM -0.38432415078784 0.348850218397964 no 2214 0.350369105097893 3254 702008
SGTC_432 NS 1619 61.3 µM -0.384901836466043 0.348630856831881 no 2215 0.350155072615811 3229 4552 A K+/calcium channel activator.
SGTC_2122 5258151 111.688 µM -0.386052057417475 0.348194240172559 no 2216 0.349729057633187 3092 2173356
SGTC_422 cantharidin 155 µM -0.38680007443659 0.347910405493098 no 2217 0.349452111056042 3020 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_129 0088-0017 176.636 µM -0.390052123305411 0.346677409396906 no 2218 0.348249002230903 3208 182446
SGTC_309 k408-0051 1.48 µM -0.390630200598695 0.346458404081724 no 2219 0.348035299502695 3142 3640463
SGTC_1873 rapamycin 2 nM -0.391214104472918 0.346237243453021 no 2220 0.347819491796855 3102 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_138 0850-0259 40.9225 µM -0.391979711200682 0.345947340119299 no 2221 0.347536602397947 3184 6813004
SGTC_3097 9117246 49.47 µM -0.394397452780945 0.345032435624264 no 2222 0.346643812048278 3099 16423892
SGTC_1783 st039459 87.517 µM -0.394640674311321 0.344940447493482 no 2223 0.34655404558058 3291 729761
SGTC_784 4579-0127 173 µM -0.394653167962762 0.344935722552125 no 2224 0.346549434745429 3288 1948547
SGTC_1299 1079-1439 3.74 µM -0.394802965603855 0.344879072857285 no 2225 0.346494153060076 3112 323161
SGTC_352 k048-0007 5.11 µM -0.396696514585939 0.344163280488328 no 2226 0.345795635353396 3193 6811911
SGTC_830 4076-0286 57.8 µM -0.396917765959 0.344079680222158 no 2227 0.345714051366672 3106 6866659
SGTC_1471 k673-0312 37 µM -0.398797443988697 0.343369747921544 no 2228 0.345021230285089 3149 24099884
SGTC_836 0330-0104 1.35 µM -0.398925398636327 0.343321441004998 no 2229 0.344974086973965 3139 46494820
SGTC_101 0490-5701 117.494 µM -0.399085910067913 0.343260846494795 no 2230 0.344914951920214 3187 4661669
SGTC_104 0074-0074 590.992 µM -0.399355073702024 0.343159243844416 no 2231 0.344815796108998 3082 3943124
SGTC_1078 idebenone 36.1 µM -0.399576124369053 0.343075811133553 no 2232 0.344734372357288 3168 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1795 st049545 62.3 µM -0.399942705398807 0.342937466736259 no 2233 0.344599358522268 3207 5291882
SGTC_1048 3161-0300 24.5 µM -0.402175727720915 0.342095199464436 no 2234 0.343777352030042 3167 2165101
SGTC_3139 9095020 49.47 µM -0.402812882718864 0.34185501657973 no 2235 0.343542941595985 3051 25236292
SGTC_346 4513-0042 7.16 µM -0.405489460952482 0.340846749755992 no 2236 0.342558881851225 3066 2827372
SGTC_877 0771-0151 33.1 µM -0.407021660791639 0.340270080887604 no 2237 0.3419960396089 3187 6166523
SGTC_2505 galangin 7.89 µM -0.407999122909792 0.339902391748442 no 2238 0.341637159414964 3049 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1156 4092-0367 4.88 µM -0.408745113016852 0.339621877190302 no 2239 0.341363361610815 3157 1357585
SGTC_3198 9112019 49.47 µM -0.408797650575324 0.339602124845302 no 2240 0.341344082103036 3139 45595555
SGTC_2475 5812728 15.03 µM -0.408850110220452 0.339582402232642 no 2241 0.341324831599966 3105 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3259 9138485 49.47 µM -0.410309776284029 0.339033805720867 no 2242 0.340789360728751 3421 17646153
SGTC_2382 9035899 200 µM -0.411872113690851 0.338446999491893 no 2243 0.340216580661461 3138 6462679
SGTC_3203 9113543 49.47 µM -0.412380882958318 0.338255992821391 no 2244 0.340030136472249 3252 17018012
SGTC_2740 felodipine 17.08 µM -0.412577206893252 0.338182298274173 no 2245 0.339958201826532 3193 3333 L-type calcium channel blocker
SGTC_368 fentichlor 4.58 µM -0.413096498255557 0.337987400625339 no 2246 0.339767957449348 3174 7329 A pesticide.
SGTC_1123 mangostin 811.285 nM -0.413826738145873 0.337713404374657 no 2247 0.339500500319687 3179 5281650 An antioxidant.
SGTC_972 1319-0219 195 µM -0.413907831294663 0.337682982389905 no 2248 0.339470804185334 3186 23903702
SGTC_823 0417-1665 178 µM -0.413999365221603 0.337648644835579 no 2249 0.339437285858278 3188 3429856
SGTC_837 0091-0265 12.5 µM -0.414401780059654 0.337497701091656 no 2250 0.339289942756038 3131 759367
SGTC_3105 9121040 49.47 µM -0.415552341914114 0.337066275534617 no 2251 0.338868803264886 3186 41448907
SGTC_1089 terbinafine 2.25 µM -0.416688180148661 0.336640580993125 no 2252 0.33845325050874 3233 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2555 cholic acid 100 µM -0.417691803599849 0.3362646126025 no 2253 0.338086232884719 3290 6708657 Influences liver metabolism.
SGTC_2163 5671233 125 µM -0.419214177007735 0.335694627334736 no 2254 0.337529805997076 3336 701023
SGTC_1489 4065-0444 182 µM -0.419589452575815 0.335554180021248 no 2255 0.337392697422768 3252 2877968
SGTC_2178 5812956 200 µM -0.419814777911093 0.335469862791511 no 2256 0.337310384194695 3124 5403383
SGTC_3327 9140648 26.9345 µM -0.420270970564213 0.335299179882567 no 2257 0.33714375704884 3266 8029710
SGTC_1967 st070177 51.4 µM -0.420307473864643 0.335285523766946 no 2258 0.337130425375865 3287 5729214
SGTC_867 0518-0118 155 µM -0.420439693537426 0.335236061373082 no 2259 0.337082138045336 3252 6848158
SGTC_2079 5212404 121 µM -0.420468356197069 0.335225339262501 no 2260 0.337071670642974 3282 758462
SGTC_1244 0416-0015 52.5 µM -0.421194019207592 0.334953928420414 no 2261 0.336806705643793 3146 96201
SGTC_1115 galangin 695.678 nM -0.42161202636643 0.334797625432523 no 2262 0.336654113327478 3297 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_898 1000-0849 28.3 µM -0.422711278401378 0.334386725141824 no 2263 0.336252962913441 3230 6751807
SGTC_328 k915-0120 63.5 µM -0.424034591906067 0.333892333816095 no 2264 0.335770292915128 3244 6624543
SGTC_2575 plumbagin 510 nM -0.424392968516112 0.333758493490109 no 2265 0.335639623940548 3089 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2211 7117706 200 µM -0.424717487288727 0.333637316052003 no 2266 0.335521317137297 3230 822771
SGTC_3189 9110682 49.47 µM -0.429186754259171 0.331970232276431 no 2267 0.333893660823244 3251 17122418
SGTC_2842 9000675 19.48 µM -0.431703625472947 0.33103287206811 no 2268 0.332978416043554 3211 2989072
SGTC_2474 5321570 43.32 µM -0.43244314650548 0.330757652558108 no 2269 0.332709682467255 3232 2841384
SGTC_2145 5634607 200 µM -0.432945334529672 0.330570810829331 no 2270 0.332527242001436 3149 308662
SGTC_1290 0986-0249 10.2 µM -0.43305179165695 0.330531208309936 no 2271 0.332488572162832 3204 53329
SGTC_3154 9100113 49.47 µM -0.433582693662716 0.330333738763794 no 2272 0.332295752184571 3156 25237525
SGTC_1312 1218-2183 165 µM -0.434088037430482 0.330145819511259 no 2273 0.3321122560097 3261 6744073
SGTC_522 1273-0010 11.6 µM -0.436420391023758 0.329279056504352 no 2274 0.331265873556182 3359 5705015
SGTC_2492 derrusnin 100 µM -0.436497366875793 0.329250465886136 no 2275 0.331237954623405 3166 1715307 Part of coumarin class of compounds.
SGTC_851 0394-0702 453 µM -0.436602836098842 0.329211293789875 no 2276 0.331199702745426 3308 762646
SGTC_451 chloral hydrate 100 µM -0.436877614518514 0.329109247736915 no 2277 0.331100053599261 3256 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_597 k018-0003 82.8 µM -0.437297647198511 0.328953282377828 no 2278 0.330947750717689 3290 6786234
SGTC_261 5-fluorouridine 15.376 µM -0.438577370741029 0.328478282664358 no 2279 0.33048389844118 3367 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3032 9089427 49.47 µM -0.441339359147022 0.327454050322498 no 2280 0.329483668028325 3251 17173707
SGTC_3339 9145883 14.936 µM -0.441525002549335 0.327385254347122 no 2281 0.329416482496631 3267 2030670
SGTC_2867 9039098 71.43 µM -0.4419850118423 0.327214808763797 no 2282 0.329250025931071 3153 6463460
SGTC_903 1134-0042 114 µM -0.441998024477301 0.327209987762887 no 2283 0.329245317738816 3183 701009
SGTC_546 peri-Naphthalide 147 µM -0.442900850383337 0.326875573697153 no 2284 0.328918726149851 3192 223824 A penicillin ester.
SGTC_287 k060-0039 29.6 µM -0.445154265441567 0.326041497314238 no 2285 0.328104137542945 3312 5861974
SGTC_2156 5649887 115 µM -0.445775276931846 0.325811789525822 no 2286 0.327879791070836 3278 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3010 9080089 71.4286 µM -0.446251719766342 0.32563560147821 no 2287 0.327707713531523 3270 17027233
SGTC_834 0312-0008 75.7 µM -0.446325354591288 0.325608374872896 no 2288 0.327681121999603 3223 6385573 YIL048W NEO1
SGTC_18 0111-0177 500 nM -0.446410067815845 0.325577053160799 no 2289 0.327650530838227 3234 721752
SGTC_725 1497-0963 19 µM -0.446564316974251 0.325520024523127 no 2290 0.327594832224064 3293 3549977
SGTC_2796 7949634 45.45 µM -0.447538454642338 0.325159963016695 no 2291 0.327243164557326 3168 2971588
SGTC_1263 0774-1208 64.8 µM -0.447757458613837 0.325079037058893 no 2292 0.327164124325773 3359 906585
SGTC_1727 st034309 9.9045 µM -0.448083435402801 0.324958597977541 no 2293 0.327046491129229 3375 870305
SGTC_2434 5670830 169.91 µM -0.448291854124517 0.32488160281803 no 2294 0.326971289377554 3264 1549830
SGTC_3285 9112818 20.8695 µM -0.449383808459656 0.324478329522361 no 2295 0.326577404741113 3202 17017947 YPR165W RHO1
SGTC_1443 4112-3303 14 µM -0.450100181935229 0.324213874973063 no 2296 0.326319102813307 3205 704433
SGTC_2435 5706476 10.6 µM -0.450715915861238 0.323986643099006 no 2297 0.326097154910815 3321 5725375
SGTC_1947 st076332 61.6 µM -0.451890819678442 0.323553235853854 no 2298 0.325673819151412 3306 24208416
SGTC_1164 k060-0068 93.7 µM -0.452581083706381 0.323298717661709 no 2299 0.325425211253883 3182 5963676
SGTC_2751 anetholtrithion 17.25 µM -0.454721455276144 0.322510033409957 no 2300 0.324654821699488 3303 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2009 4012297 12.05 µM -0.45581890488322 0.322105954364772 no 2301 0.324260104251901 3278 45595307
SGTC_1052 3253-3998 198 µM -0.456535385816693 0.321842260698531 no 2302 0.324002515509309 3172 5450317
SGTC_2856 9022925 19.48 µM -0.456602364548446 0.321817614426518 no 2303 0.323978439664923 3311 4944862
SGTC_20 0481-0013 4.944 µM -0.45667871276569 0.32178952140591 no 2304 0.323950996809517 3266 182045
SGTC_1648 st011736 69.8 µM -0.457429302445883 0.321513389369372 no 2305 0.323681253337654 3347 2855514
SGTC_1291 0993-0025 5.79 µM -0.457555856478197 0.321466841520576 no 2306 0.323635782050007 3328 4353356
SGTC_2384 9036245 200 µM -0.457685873698833 0.321419022795686 no 2307 0.323589069169231 3232 6462766
SGTC_1960 st011366 51.8 µM -0.458588962921846 0.321086959462381 no 2308 0.32326468197417 3231 3972846
SGTC_2747 doxorubicin 7.63 µM -0.459731417189538 0.32066708720324 no 2309 0.322854507966956 3205 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_283 0987-0079 11.7 µM -0.461863874165632 0.319883985189238 no 2310 0.32208947097646 3310 411556
SGTC_2962 9082311 13.18 µM -0.462626490379628 0.319604124208183 no 2311 0.321816058638227 3168 16459453
SGTC_3239 9133757 49.47 µM -0.46269801742223 0.319577880846879 no 2312 0.321790419785582 3275 17036923
SGTC_1631 benzylvanillin 81.9 µM -0.465341621614747 0.318608573861886 no 2313 0.320843416529631 3316 75506
SGTC_322 k048-0136 19.3 µM -0.466431601276106 0.318209281280387 no 2314 0.320453298015082 3290 6823282
SGTC_2540 epiandrosterone 100 µM -0.466756196018698 0.318090413172136 no 2315 0.32033715945188 3306 441302 A steroid.
SGTC_1440 4100-1550 40 µM -0.467893792980405 0.317673967813575 no 2316 0.319930271238522 3263 742806
SGTC_1338 1486-1223 76 µM -0.468184804719183 0.317567472821579 no 2317 0.319826218832404 3267 3444526
SGTC_3243 9134147 49.47 µM -0.468866386300476 0.317318108898209 no 2318 0.319582572117278 3321 24282180
SGTC_2840 9008771 71.43 µM -0.469773873677831 0.316986223598756 no 2319 0.319258291123518 3266 2992978
SGTC_732 3970-1727 52.7 µM -0.471755199834042 0.316262126902883 no 2320 0.318550765822315 3331 1275699
SGTC_225 nsc-122657 1.016 µM -0.4721410018301 0.316121213265938 no 2321 0.318413073970393 3309 275685
SGTC_921 1561-0023 372 µM -0.472396854941065 0.316027778003117 no 2322 0.31832177440852 3220 24050882
SGTC_2814 7977482 42.97 µM -0.472511668112759 0.315985853081029 no 2323 0.318280807642011 3343 6456762
SGTC_959 1222-0044 107 µM -0.472624444091957 0.315944674359552 no 2324 0.318240569934709 3335 6083612
SGTC_2085 5307070 144.047 µM -0.47271474268653 0.315911704616912 no 2325 0.318208353552397 3190 2840351
SGTC_911 3456-4043 236 µM -0.474016285469314 0.31543664924642 no 2326 0.317744147026151 3299 914281
SGTC_2860 9025725 38.96 µM -0.474936787095077 0.31510085565101 no 2327 0.317416014944744 3183 40546248
SGTC_1319 1306-0155 43.7 µM -0.47538967424287 0.314935701116364 no 2328 0.317254626463608 3269 3122360
SGTC_2314 7727897 200 µM -0.475418240573718 0.314925285061361 no 2329 0.317244447880814 3220 900724
SGTC_1159 4092-0538 61.2 µM -0.476125796396422 0.314667338111819 no 2330 0.316992379986874 3265 717301
SGTC_1786 berberine 21.6 µM -0.476229029896878 0.314629710804235 no 2331 0.316955609982316 3296 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3089 9117425 49.47 µM -0.477407209880588 0.314200415503816 no 2332 0.316536090568857 3294 9401657
SGTC_1815 st051655 58.2 µM -0.477825062254081 0.314048222296197 no 2333 0.316387360793508 3315 5984156
SGTC_2568 diosmetin 100 µM -0.478239762664436 0.313897208381936 no 2334 0.316239782280704 3398 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_665 3914-0008 307 µM -0.479349805606312 0.31349313762685 no 2335 0.315844897833058 3231 1069549
SGTC_2971 9092186 9.93 µM -0.480052141180484 0.313237593426394 no 2336 0.315595158862473 3200 25236400
SGTC_1008 4106-0037 6 µM -0.48118339404271 0.312826176576061 no 2337 0.315193081010428 3271 2905394
SGTC_1033 k072-0102 21.3 µM -0.482135049124329 0.312480256735312 no 2338 0.314855006507227 3360 5965931
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.482439383540016 0.312369668184046 no 2339 0.314746924730479 3363 7104
SGTC_2529 gangaleoidin 93.61 µM -0.483993704879592 0.31180512510526 no 2340 0.314195168373192 3227 4565183
SGTC_2965 9082772 38.63 µM -0.485566544704413 0.311234305749279 no 2341 0.313637260652675 3406 16459634
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.486617537818997 0.310853129178922 no 2342 0.313264696399417 3313 1241132 A phosphatase inhibitor.
SGTC_478 N-arachidonylglycine 10 µM -0.487260290840594 0.310620114002225 no 2343 0.313036942137819 3292 5283389
SGTC_847 0342-0274 5.54 µM -0.488680538173088 0.31010550576271 no 2344 0.312533942146277 3338 18097
SGTC_1892 st058411 7.36 µM -0.489900193595034 0.309663876001775 no 2345 0.312102263021565 3333 3934738
SGTC_1833 st055984 71 µM -0.491216615401971 0.309187515895691 no 2346 0.311636624224316 3269 676288
SGTC_505 gw-5074 63.9 µM -0.492156775764753 0.308847505859212 no 2347 0.311304259147085 3372 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2536 dehydroabietamide 32.04 µM -0.492593632171593 0.308689571961122 no 2348 0.311149874168691 3397 3983547
SGTC_2431 5490079 200 µM -0.493036666985769 0.308529440555012 no 2349 0.310993339669306 3300 5722345
SGTC_3351 9150312 21.596 µM -0.49314722784004 0.308489484890502 no 2350 0.310954281278802 3342 4904905
SGTC_3069 9117009 49.47 µM -0.4936125966254 0.308321329807379 no 2351 0.310789901451664 3257 41904981
SGTC_2068 5226020 147 µM -0.494653163354526 0.307945479789137 no 2352 0.310422484042393 3295 1810509
SGTC_739 1486-1183 203 µM -0.498115813244682 0.306696231242339 no 2353 0.309201207729087 3375 4346692
SGTC_2218 6965428 192.983 µM -0.498262518948229 0.306643352437087 no 2354 0.309149511036469 3355 675684
SGTC_2853 9015042 58.44 µM -0.498573669405228 0.306531214259532 no 2355 0.309039879207219 3198 6457456
SGTC_1723 st034307 2.5525 µM -0.50119054111952 0.305588814997512 no 2356 0.308118515305244 3323 867466
SGTC_1396 3511-0007 98.6 µM -0.501916272787854 0.305327688928947 no 2357 0.307863209035058 3347 X1396
SGTC_3083 9117465 49.47 µM -0.50296873302508 0.30494917836708 no 2358 0.307493127634328 3345 16420915
SGTC_2929 9013348 24.6 µM -0.503121564646257 0.304894230793026 no 2359 0.307439403031201 3320 2995952
SGTC_280 3448-3607 3.04 µM -0.504968889739369 0.30423041001845 no 2360 0.306790343434275 3378 626179
SGTC_2189 6047310 154.431 µM -0.505157594463963 0.304162636812244 no 2361 0.306724075872304 3296 711535
SGTC_2306 7482397 179.52 µM -0.506349174088854 0.303734837034721 no 2362 0.306305774022072 3414 891448
SGTC_1842 st055362 61.2 µM -0.506428415979653 0.30370639721097 no 2363 0.30627796524358 3287 676032
SGTC_220 paclitaxel 373.376 µM -0.506851627027246 0.30355452737913 no 2364 0.306129464436865 3358 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2060 5238662 140 µM -0.506968616134645 0.303512551670429 no 2365 0.306088419669334 3329 790130
SGTC_892 0929-0076 29 µM -0.507263290955147 0.303406833792656 no 2366 0.30598504596559 3304 5751038
SGTC_2439 5492030 7.2 µM -0.511258573021419 0.301975108805249 no 2367 0.304585004566006 3362 5722370
SGTC_2320 7373003 200 µM -0.513108648013804 0.30131315681258 no 2368 0.303937661244473 3368 5415828
SGTC_2160 5660466 132.927 µM -0.51313068423204 0.301305276250273 no 2369 0.303929954445259 3377 2859134
SGTC_1893 st059353 36.1 µM -0.513363536620264 0.301222009569386 no 2370 0.30384852353834 3346 3112488
SGTC_1715 st032160 10.2275 µM -0.513501373894914 0.301172724633482 no 2371 0.303800324992884 3355 5289825
SGTC_2216 7189485 200 µM -0.514039425614237 0.30098037426446 no 2372 0.303612213255475 3381 731273
SGTC_3096 9117468 49.47 µM -0.51482894170014 0.300698227152027 no 2373 0.303336279618427 3353 41316311
SGTC_1004 4084-0029 199 µM -0.516670385226048 0.300040620086024 no 2374 0.30269313631046 3410 716894 YLR208W SEC13
SGTC_558 k064-0027 21.3 µM -0.517192604256664 0.299854246333926 no 2375 0.302510857129679 3356 5088526
SGTC_1260 0700-1617 7.75 µM -0.519053931867061 0.299190387399294 no 2376 0.301861566270233 3382 2853078
SGTC_100 0086-0128 49.5915 µM -0.522037287119649 0.298127741072462 no 2377 0.300822184669645 3345 93297
SGTC_2798 7813637 45.45 µM -0.522284749309856 0.298039674375071 no 2378 0.30073604300503 3407 956368
SGTC_1661 st013063 9.66 µM -0.522693460831756 0.297894248326745 no 2379 0.300593794777735 3351 721395
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.522701420725509 0.297891416391389 no 2380 0.300591024712663 3319 5106787 A p450 inhibitor.
SGTC_1422 4031-0024 15.5 µM -0.525292145595644 0.296970352840224 no 2381 0.299690058337259 3359 782427
SGTC_2698 st077697 67.5 µM -0.526861174338111 0.296413160472759 no 2382 0.299144998741848 3324 3154499
SGTC_353 1988-1175 58.3 µM -0.528702493992769 0.295759884217374 no 2383 0.298505923415017 3276 2788357
SGTC_565 1418-0001 44.5 µM -0.52871396248321 0.295755817419851 no 2384 0.298501944939999 3467 2862145
SGTC_1067 clotrimazole 1.36 µM -0.530155505001414 0.295244842258299 no 2385 0.298002059052045 3353 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_702 1488-0190 94 µM -0.530415687144281 0.295152660320076 no 2386 0.297911875956986 3404 949357
SGTC_372 0155-0182 15.9 µM -0.530490548702599 0.295126139496446 no 2387 0.297885930105526 3372 771486
SGTC_2744 captopril 92.04 µM -0.53079919158229 0.295016809743056 no 2388 0.297778970167411 3378 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2029 5175081 200 µM -0.53122795077178 0.294864962476243 no 2389 0.297630413098571 3384 1380876
SGTC_2765 myclobutanil 7.74 µM -0.531458010641602 0.294783500446275 no 2390 0.297550715587048 3425 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3274 9138298 49.47 µM -0.532729602723196 0.294333428972014 no 2391 0.29711038555841 3388 17015756
SGTC_207 4185-0010 4.486 µM -0.536862110890486 0.292872951432502 no 2392 0.295681432310766 3467 3761753
SGTC_632 0781-2353 4.65 µM -0.537286826088455 0.292723042844608 no 2393 0.295534751951728 3426 6811515 YHR007C ERG11
SGTC_3167 9103034 49.47 µM -0.537587210155048 0.292617040017219 no 2394 0.295431031007138 3421 5127859
SGTC_1334 1486-0610 236 µM -0.538058499415232 0.292450762238544 no 2395 0.295268331205558 3415 3742339
SGTC_1362 1611-0397 101 µM -0.538402941612215 0.292329265756042 no 2396 0.295149447993818 3370 27816
SGTC_3348 9149464 3.537 µM -0.538515277322769 0.2922896462055 no 2397 0.295110680420274 3405 1951442
SGTC_2719 novobiocin 32.65 µM -0.538685383812259 0.292229656301257 no 2398 0.295051980348028 3460 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3346 9158254 43.5805 µM -0.538967928874748 0.292130026371264 no 2399 0.29495449204199 3394 17639500
SGTC_288 1315-0019 35.1 µM -0.539576454125098 0.291915504289411 no 2400 0.294744579156172 3458 6811474
SGTC_1710 st031758 61.5 µM -0.540249789409512 0.291678220406406 no 2401 0.294512390140369 3475 5394341
SGTC_2956 9076196 2.52 µM -0.540269145811391 0.291671400524731 no 2402 0.294505716639889 3475 16423868
SGTC_1392 3455-1037 33.9 µM -0.540855025478676 0.291465011494166 no 2403 0.294303756127511 3480 981132
SGTC_2131 toluylene red 5.2905 µM -0.541512069230155 0.291233634415645 no 2404 0.294077340527818 3351 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2109 5483026 200 µM -0.541748686337438 0.291150331022506 no 2405 0.293995822598664 3379 759335
SGTC_824 1304-0008 100 µM -0.544621559450639 0.290139796446421 no 2406 0.293006911855228 3362 768245
SGTC_716 1683-5115 658 µM -0.544881543239448 0.290048428173929 no 2407 0.292917495499376 3465 723597
SGTC_489 paxilline 115 µM -0.545574473524725 0.289804971803139 no 2408 0.292679237514217 3422 105008 A toxic potassium channel blocker.
SGTC_2684 capsaicin 100 µM -0.546042072382149 0.289640738299746 no 2409 0.292518508643741 3453 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_684 1140-0066 328 µM -0.546080687153514 0.289627177689395 no 2410 0.292505237330154 3429 6813534
SGTC_3040 9091894 49.47 µM -0.546452517207258 0.289496614870052 no 2411 0.292377459281038 3357 25236966
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.547181039876122 0.28924088469322 no 2412 0.292127180380304 3357 688667
SGTC_1076 itraconazole 331 nM -0.5485304360523 0.288767492658311 no 2413 0.291663868259785 3443 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2455 5377712 9.75 µM -0.54877049456829 0.288683314121979 no 2414 0.291581480612934 3409 2243908
SGTC_113 0099-0221 2.5 µM -0.549102856259634 0.28856678778134 no 2415 0.291467432599015 3500 89219
SGTC_2936 9038235 15.59 µM -0.550139615303254 0.288203441477334 no 2416 0.29111180841646 3406 4749415
SGTC_112 phenothiazine 287.218 µM -0.551785532845159 0.287627050980153 no 2417 0.290547650168799 3457 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3272 9137413 49.47 µM -0.55204382302436 0.287536648784594 no 2418 0.290459164532469 3409 17614870
SGTC_487 nimodipine 119 µM -0.558651101070551 0.285228665399591 no 2419 0.288199928804266 3378 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2462 5162487 171.77 µM -0.558729261213175 0.285201416248616 no 2420 0.288173253080226 3440 2259986
SGTC_3232 9132874 49.47 µM -0.559885867254935 0.284798331089521 no 2421 0.287778644584935 3392 3784940
SGTC_168 3970-0862 530.542 µM -0.56265788443903 0.283833372112932 no 2422 0.286833933880608 3443 3135186
SGTC_926 2268-1401 59.4 µM -0.56387557252677 0.283409981547309 no 2423 0.286419407734696 3472 2931578
SGTC_3075 9116269 49.47 µM -0.564002565295522 0.283365843558497 no 2424 0.286376193153089 3504 17015205 YNL244C SUI1
SGTC_2371 9071574 200 µM -0.564320179407919 0.283255467073874 no 2425 0.286268125267515 3450 45596039
SGTC_977 1348-1378 135 µM -0.564383933286783 0.28323331396615 no 2426 0.286246435407475 3423 X977
SGTC_2286 7945697 125 µM -0.565433579988615 0.282868703744759 no 2427 0.285889444827089 3411 1245733
SGTC_1114 scopoletin 1.73284 µM -0.565906789441893 0.282704401232664 no 2428 0.285728572960124 3489 5280460 A coumarin with genotoxic properties.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.566193987858229 0.282604705766404 no 2429 0.285630958243589 3377 88881 An O-methylated flavonoid and antioxidant.
SGTC_146 3448-8650 53.125 µM -0.566269358952872 0.282578544924571 no 2430 0.285605343293881 3426 2891488 YIL048W NEO1
SGTC_923 1900-2434 73.3 µM -0.568916512704724 0.28166047344185 no 2431 0.284706399344897 3449 5910570
SGTC_361 000s-0510 1.45 µM -0.569385565904129 0.281497949078991 no 2432 0.284547255066606 3424 660
SGTC_1985 st071382 65.5 µM -0.571145703264628 0.280888474884877 no 2433 0.283950440137749 3491 6123237
SGTC_1216 1165-0504 9.65 µM -0.571576997505637 0.280739230087497 no 2434 0.283804291361809 3505 6304004
SGTC_144 4161-2749 112.381 µM -0.571826310333075 0.280652975523785 no 2435 0.28371982540987 3416 797501 YMR168C CEP3
SGTC_1705 st027868 56.3335 µM -0.572294052300881 0.280491185798948 no 2436 0.283561389235293 3463 292948
SGTC_2341 7987486 176.74 µM -0.573651828658763 0.280021793295702 no 2437 0.283101715930784 3496 1258686
SGTC_3064 1327-0027 10 µM -0.574660361895803 0.279673383158006 no 2438 0.28276051001922 3398 16000455 YPR107C YTH1
SGTC_971 1315-0384 26.7 µM -0.576544479728715 0.279023055817691 no 2439 0.282123607067641 3445 6769120
SGTC_1282 0886-0010 32.4 µM -0.579189236808017 0.278111426722991 no 2440 0.281230746242049 3549 2836211 YNL267W PIK1
SGTC_2670 beta-carotene 100 µM -0.582280544332058 0.277047719746706 no 2441 0.280188864084168 3463 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3258 9138477 49.47 µM -0.583118640071772 0.276759677734135 no 2442 0.279906718164733 3518 4970355
SGTC_2866 9034245 58.44 µM -0.583137930212104 0.276753049705085 no 2443 0.279900225738712 3448 6462273
SGTC_1364 1653-0028 37.6 µM -0.583771028121988 0.27653556250456 no 2444 0.279687186370206 3465 5718652
SGTC_3329 9141233 27.5565 µM -0.584117653225724 0.276416522395662 no 2445 0.279570579316126 3529 4909101 YNL103W MET4
SGTC_2229 7354935 190 µM -0.585022049506438 0.276106047484457 no 2446 0.279266445400371 3458 318112
SGTC_2433 5607874 27.82 µM -0.585480382784588 0.275948769257075 no 2447 0.279112376706189 3472 2252428
SGTC_973 1325-0077 65.9 µM -0.585799737339776 0.275839207949573 no 2448 0.279005050133463 3492 2835149
SGTC_1635 st007035 42.4 µM -0.587175576512022 0.275367441871639 no 2449 0.278542896830694 3513 3716403
SGTC_744 1594-0068 283 µM -0.587414829189498 0.275285444266824 no 2450 0.278462568380341 3496 668392
SGTC_159 3970-0959 50 µM -0.588220870258303 0.275009283228 no 2451 0.27819202533127 3596 6615653
SGTC_1713 st033146 12.748 µM -0.588910352459998 0.274773165254596 no 2452 0.277960706357248 3529 674619
SGTC_1977 st070720 65.3 µM -0.590380884690178 0.274269905411055 no 2453 0.277467661525825 3507 682188
SGTC_3177 9107506 49.47 µM -0.590797524126347 0.274127401801293 no 2454 0.277328047054994 3483 8897194
SGTC_183 3914-0051 30.55 µM -0.592245051071507 0.273632587167648 no 2455 0.276843252832477 3491 1596232
SGTC_2165 5727197 32.143 µM -0.592366668325866 0.273591034328703 no 2456 0.276802540656794 3654 1361712
SGTC_1944 st076371 56.9 µM -0.594080849509527 0.273005684244489 no 2457 0.276229019414841 3396 24208455
SGTC_610 4215-0184 155 µM -0.594979363038371 0.272699112508386 no 2458 0.275928632853001 3519 5605015
SGTC_696 1560-0013 611 µM -0.595121876836608 0.272650502673431 no 2459 0.275881003098007 3578 1650269
SGTC_1920 st075728 45.7 µM -0.595273169179119 0.272598903283345 no 2460 0.275830443872638 3550 3400306
SGTC_1002 4049-0206 172 µM -0.596255108309491 0.272264123438925 no 2461 0.275502407889374 3511 4662749
SGTC_1389 3405-0187 19 µM -0.597025957192899 0.272001455390716 no 2462 0.27524502525129 3444 799890
SGTC_1993 st073995 70.8 µM -0.598550595315154 0.271482303810257 no 2463 0.274736304951156 3482 3098394
SGTC_2658 polymyxin b sulfate 77.05 µM -0.598554340526398 0.271481029143581 no 2464 0.274735055871555 3496 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_645 0845-0943 5.41 µM -0.598922155342123 0.271355859464711 no 2465 0.274612398200652 3473 1885106
SGTC_1208 2323-2347 50.3 µM -0.599071313294379 0.271305108279082 no 2466 0.274562665198047 3526 5412760
SGTC_228 caffeine 993.056 µM -0.5991976850366 0.271262113833009 no 2467 0.274520533166713 3526 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3036 9090181 49.47 µM -0.600309714731059 0.270883923371798 no 2468 0.274149922772055 3527 25236586
SGTC_1498 4478-3555 97.6 µM -0.601573845206116 0.270454324737475 no 2469 0.273728921562758 3521 3437919
SGTC_2817 7995342 71.43 µM -0.602004789214599 0.270307951760431 no 2470 0.273585474733078 3412 18879975
SGTC_86 0417-1630 471.922 µM -0.602710795757256 0.270068237599363 no 2471 0.273350549218855 3553 3634867
SGTC_576 1073-0113 22.7 µM -0.603044209097247 0.269955068977808 no 2472 0.273239639801991 3665 5439563
SGTC_2896 9052656 71.43 µM -0.60359453001466 0.269768328564586 no 2473 0.273056625203616 3491 6469436
SGTC_389 tpck 16.7 µM -0.605787555642088 0.269024812222252 no 2474 0.272327917172768 3500 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1868 st057644 42.7 µM -0.607112174965408 0.268576216341666 no 2475 0.271888235455637 3477 688665
SGTC_297 0986-0032 24 µM -0.607201300383496 0.268546046612034 no 2476 0.271858664685316 3480 2847425
SGTC_726 3448-4391 34.2 µM -0.608309119616186 0.26817118240394 no 2477 0.271491236846095 3619 1356692
SGTC_1377 2944-0135 198 µM -0.609043458165065 0.267922841913423 no 2478 0.271247816881535 3552 1894137
SGTC_759 3486-0358 89.3 µM -0.611653907198844 0.2670409722562 no 2479 0.270383381928048 3577 875103
SGTC_376 3970-0862 59.1 µM -0.612115854037915 0.266885068780117 no 2480 0.270230554444733 3526 3135186
SGTC_3123 9126162 49.47 µM -0.612147149013844 0.266874508631769 no 2481 0.270220202581248 3562 25239884
SGTC_2897 9048598 12.99 µM -0.612647258088935 0.266705780925595 no 2482 0.270054801632668 3469 6467404
SGTC_2651 TUB2.036 5 µM -0.613134551620437 0.266541428834283 no 2483 0.269893687903881 3636 15992207 YFL037W TUB2
SGTC_444 curcumin 90.4 µM -0.615156574724341 0.265859997982669 no 2484 0.26922566143282 3519 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1209 2323-2347 50.3 µM -0.616158900897252 0.265522537161114 no 2485 0.268894825372619 3530 5412760
SGTC_2370 9071495 200 µM -0.616676344424293 0.265348410573454 no 2486 0.268724113614397 3504 21791103
SGTC_3209 9113616 49.47 µM -0.616830427393499 0.265296570818469 no 2487 0.268673290039735 3582 16649353
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.61749503255929 0.265073029635734 no 2488 0.268454128371972 3496 4174840
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.619639867829834 0.264352263552741 no 2489 0.267747456436589 3530 6312947
SGTC_3248 9135562 49.47 µM -0.620438073867461 0.264084283546433 no 2490 0.267484706164734 3583 17650701
SGTC_3072 9116419 49.47 µM -0.621645139522055 0.263679301046021 no 2491 0.267087616263964 3506 17170162
SGTC_781 4335-2806 94.4 µM -0.621703496994516 0.263659729566577 no 2492 0.267068425878414 3601 845254
SGTC_2257 7960413 200 µM -0.622212788875818 0.263488958639733 no 2493 0.266900978894494 3540 2974689 YIL048W NEO1
SGTC_3035 9091303 49.47 µM -0.622988494961478 0.263228964744511 no 2494 0.266646041152928 3585 25237002
SGTC_419 nsc-638432 893 µM -0.623573920220569 0.263032834196428 no 2495 0.266453721230509 3513 368090
SGTC_1009 4106-0057 9.87 µM -0.623726560138402 0.262981708690255 no 2496 0.266403588538792 3581 2928005
SGTC_1255 0566-0045 221 µM -0.62409847747306 0.262857159256673 no 2497 0.266281456876903 3576 2788469
SGTC_974 1326-0144 138 µM -0.624981315564177 0.262561631095552 no 2498 0.265991660587058 3549 5411856
SGTC_1180 1193-0155 285 µM -0.626130947537143 0.262177049316671 no 2499 0.265614527423885 3561 2921347
SGTC_990 3985-0011 41.3 µM -0.626528832791616 0.262044013622372 no 2500 0.265484065611896 3505 5399565 YGL099W LSG1
SGTC_3033 9090887 49.47 µM -0.626802297934214 0.261952598723499 no 2501 0.265394418519752 3519 19325384
SGTC_1739 st037196 92.5 µM -0.63079097479195 0.260621110701437 no 2502 0.264088602663876 3583 612214
SGTC_350 k064-0020 19.8 µM -0.63137048263089 0.260427951397293 no 2503 0.263899155682245 3573 2790705
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.633410269466797 0.259748644560078 no 2504 0.263232880242603 3539 115019
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.634153690969272 0.259501291689666 no 2505 0.262990263056397 3519 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_922 1866-0035 480 µM -0.634498748386531 0.259386524759608 no 2506 0.262877691686749 3564 3156169
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.635163824663439 0.259165392783904 no 2507 0.262660787046563 3633 688751
SGTC_1717 st033143 58.0435 µM -0.636103698791074 0.258853059209172 no 2508 0.262354417431664 3607 674616
SGTC_3128 9127691 49.47 µM -0.636833997284932 0.258610505134885 no 2509 0.26211648933752 3549 41316314
SGTC_2581 avocatin a 64 µM -0.637376747049371 0.258430317888671 no 2510 0.261939735466326 3543 6710728 A skin care supplement.
SGTC_1398 3558-0053 112 µM -0.637612024038282 0.258352228601345 no 2511 0.261863133295517 3496 4532369
SGTC_307 1501-1223 22.3 µM -0.638229865061481 0.258147223147853 no 2512 0.261662029519791 3569 2830329
SGTC_2215 7188065 200 µM -0.638658317006354 0.258005108309606 no 2513 0.261522617374779 3594 940217
SGTC_1158 4092-0494 91.8 µM -0.63898021987254 0.257898361840419 no 2514 0.261417899871693 3629 1148199
SGTC_16 erodoxin 22.806 µM -0.640829554343825 0.257285546819944 no 2515 0.26081671448032 3611 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_647 0140-0236 81 µM -0.641137931700368 0.257183433316132 no 2516 0.26071653577927 3593 990837
SGTC_1861 st057647 17.4 µM -0.641192869461149 0.257165243896166 no 2517 0.260698690913168 3619 688668
SGTC_2413 inermin 26.06 µM -0.641313654614125 0.257125255323209 no 2518 0.260659459728196 3653 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_294 k038-0071 157 µM -0.641896018378797 0.256932496420355 no 2519 0.260470349823369 3579 24152826
SGTC_3133 9127736 49.47 µM -0.642597457603348 0.256700424114247 no 2520 0.260242666603144 3606 27243420
SGTC_2607 solasodine 47.35 µM -0.643018581151062 0.256561147153661 no 2521 0.260106021559577 3579 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_281 1672-3440 14.9 µM -0.6442381171622 0.25615803571495 no 2522 0.259710518528446 3580 6833000
SGTC_3269 9137823 49.47 µM -0.645574746948239 0.255716599193141 no 2523 0.259277398058877 3523 17682936
SGTC_2979 9012552 45.46 µM -0.645828976331488 0.255632682155484 no 2524 0.259195060039545 3659 17100905
SGTC_1409 3909-8004 61.9 µM -0.645850677535009 0.255625519602909 no 2525 0.259188032232979 3588 2119279
SGTC_1470 k295-0292 231 µM -0.647557614335325 0.255062468091616 no 2526 0.25863555956179 3609 5045612
SGTC_1388 3346-4487 254 µM -0.647659179062953 0.255028986331977 no 2527 0.258602706023334 3624 3345614
SGTC_1656 st012921 11 µM -0.650572983396508 0.254069403657605 no 2528 0.25766108747348 3552 6732821
SGTC_2782 7736369 71.43 µM -0.650574918367305 0.254068767057195 no 2529 0.257660462764601 3629 2950836 YOL077C BRX1
SGTC_3146 9095609 49.47 µM -0.651436089452244 0.253785527065032 no 2530 0.257382510175723 3598 17173999
SGTC_1250 0485-0349 40.2 µM -0.652271380480885 0.253510957510119 no 2531 0.25711305959338 3571 6842794 YDL195W SEC31
SGTC_3199 9111318 49.47 µM -0.65242237241654 0.253461341424929 no 2532 0.257064367840432 3562 8548020
SGTC_1913 st060213 96.1 µM -0.655139740959032 0.25256928470363 no 2533 0.256188893625924 3630 688959
SGTC_3153 9100258 49.47 µM -0.655286601722297 0.252521120462642 no 2534 0.256141622755167 3542 25236848
SGTC_883 0850-0245 24.6 µM -0.657067035856208 0.251937597070664 no 2535 0.255568906792404 3635 6823229 YPR165W RHO1
SGTC_1166 k206-0078 225 µM -0.657583694566772 0.251768399524165 no 2536 0.255402837410415 3608 5404595
SGTC_1165 k072-0275 30.3 µM -0.657894539280056 0.251666631717955 no 2537 0.255302949909204 3636 6153523 YGL055W OLE1
SGTC_2984 9022109 38.96 µM -0.657929707103556 0.251655119452218 no 2538 0.255291650292046 3656 6459207
SGTC_406 estrone 100 µM -0.657974994180345 0.251640295035993 no 2539 0.255277099687678 3625 5870 A steroid.
SGTC_1555 citronellol 128 µM -0.658582849418964 0.251441362416431 no 2540 0.255081839561917 3578 8842 A terpine precursor.
SGTC_2269 7935389 174.42 µM -0.659339024454055 0.25119400527383 no 2541 0.254839044050469 3592 97605
SGTC_994 3910-0338 138 µM -0.661664538667532 0.250434098982584 no 2542 0.254093117976529 3678 3479481
SGTC_619 1652-1634 108 µM -0.662019061773101 0.250318358891755 no 2543 0.253979502730947 3560 5400454
SGTC_2525 harmine 47.85 µM -0.662343729115408 0.250212390603973 no 2544 0.253875478853867 3574 5280953 A monoamine oxidase inhibitor
SGTC_12 0849-0099 9.267 µM -0.662759738723851 0.250076643860941 no 2545 0.253742221477362 3558 6071388
SGTC_1933 st074711 15.9 µM -0.664146165819306 0.24962452556895 no 2546 0.253298382517343 3616 17250958
SGTC_1432 4049-0298 68.4 µM -0.664880226926389 0.249385321822894 no 2547 0.253063551815345 3632 741646
SGTC_218 alverine citrate 93.75 µM -0.665985372482989 0.249025425108747 no 2548 0.252710225030898 3622 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3142 9086498 49.47 µM -0.666719706084107 0.248786438248411 no 2549 0.252475594510367 3568 25236367
SGTC_2794 7785382 27.27 µM -0.666768105703156 0.248770691015457 no 2550 0.252460134144759 3608 2205081
SGTC_1994 st072947 40.9 µM -0.666780982340762 0.248766501579879 no 2551 0.252456021024401 3645 5286565 YDL195W SEC31
SGTC_1192 1488-0095 21.4 µM -0.666793759510625 0.248762344543429 no 2552 0.252451939711436 3608 915875
SGTC_2173 5763948 167 µM -0.667077691686216 0.248669977104767 no 2553 0.25236125441561 3627 2867177
SGTC_2252 omeprazole 400 µM -0.667923672987294 0.248394874897726 no 2554 0.252091157693086 3575 4594 A proton pump inhibitor.
SGTC_2610 ononetin 44.17 µM -0.668689275887974 0.248146050608649 no 2555 0.251846854924656 3628 259632
SGTC_1229 0139-0193 12.2 µM -0.669202902305118 0.247979194320486 no 2556 0.251683027561129 3659 3090752
SGTC_614 0462-0418 107 µM -0.669440577221994 0.247902003694023 no 2557 0.251607237321896 3505 5188303
SGTC_2686 alizarin 95.37 µM -0.669693122216899 0.247819997708338 no 2558 0.25152671849652 3594 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1057 3448-5381 134 µM -0.673357421252801 0.246631763919431 no 2559 0.250359964976935 3652 5497911
SGTC_2473 5854593 8.94 µM -0.673487399772841 0.246589671487557 no 2560 0.250318631125926 3585 2872951
SGTC_1729 st035615 45.989 µM -0.675835829573285 0.245829815892214 no 2561 0.24957244176111 3618 17385451
SGTC_806 3966-4455 5.86 µM -0.676405910831584 0.245645550733737 no 2562 0.249391482730945 3567 714982
SGTC_1309 pyrazolanthrone 13.4 µM -0.678231192104266 0.245056071424437 no 2563 0.248812559107491 3664 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1464 k208-0027 110 µM -0.678705481607473 0.244903023045374 no 2564 0.248662246117337 3661 X1464
SGTC_625 k213-0058 121 µM -0.680447605305152 0.24434129925545 no 2565 0.248110543357096 3703 3655420
SGTC_2369 9071472 200 µM -0.681819619069802 0.243899401566165 no 2566 0.247676508534749 3671 17296037
SGTC_1980 st071811 45.7 µM -0.682295059336528 0.243746372610912 no 2567 0.247526198267392 3690 4974850
SGTC_1642 st009582 77.7 µM -0.683403284572478 0.243389871798368 no 2568 0.247176022552219 3660 6739311
SGTC_577 r071-0003 38.6 µM -0.683562975109161 0.243338524783697 no 2569 0.247125585570591 3682 4568517 YMR134W ERG29
SGTC_1228 0124-0032 52.5 µM -0.684191831041511 0.243136378907009 no 2570 0.246927019976392 3692 X1228
SGTC_2708 st078559 56 µM -0.68455332217446 0.243020218616283 no 2571 0.246812915320101 3586 17250902
SGTC_1410 3909-8106 77.9 µM -0.684850759908886 0.242924663534445 no 2572 0.246719050287287 3667 1039210
SGTC_3063 1327-0034 4 µM -0.687806244775748 0.24197628756049 no 2573 0.24578740153573 3586 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2974 9094440 9.66 µM -0.688907188057088 0.241623523492362 no 2574 0.24544083785812 3709 25236134
SGTC_2506 ethyl hematommate 54.16 µM -0.689354616748112 0.241480238298063 no 2575 0.245300067775825 3660 3940691 An allergen.
SGTC_3347 9188721 44.724 µM -0.689699448172833 0.241369840493921 no 2576 0.245191606481656 3665 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_849 0386-0493 241 µM -0.691003742425248 0.240952518713342 no 2577 0.244781594600441 3626 726119
SGTC_547 1120-0019 610 nM -0.691307389589313 0.240855420162057 no 2578 0.244686194480147 3626 3676939
SGTC_2432 5630864 12.22 µM -0.692473565126654 0.240482705176559 no 2579 0.24431999063837 3640 5714970
SGTC_42 0133-0086 60.653 µM -0.692786801272836 0.2403826470248 no 2580 0.244221678200776 3613 162923 Model of phenazepam hydroxylation.
SGTC_2745 rifampicin 24.3 µM -0.693525004799592 0.240146929734753 no 2581 0.24399006969524 3592 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1974 st069448 26.9 µM -0.694460188541148 0.239848495276188 no 2582 0.243696829629423 3636 6323587 YNR016C ACC1
SGTC_724 3910-0327 137 µM -0.696049604937273 0.239341747502126 no 2583 0.243198882498756 3665 2885483
SGTC_443 clozapine 122 µM -0.69629831030119 0.23926250663589 no 2584 0.243121015572641 3598 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_257 daunorubicin 18.5 µM -0.697600944816389 0.238847704035657 no 2585 0.242713395281674 3707 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3311 9131146 2.8755 µM -0.697849735820751 0.238768525378738 no 2586 0.242635585718444 3679 4900406 YPR165W RHO1
SGTC_166 k072-0058 166.424 µM -0.6978892700503 0.238755944786333 no 2587 0.242623222603818 3683 5846229
SGTC_182 3448-4371 550.524 µM -0.698822163297935 0.238459184530988 no 2588 0.242331587939125 3687 3491403
SGTC_2628 lathosterol 100 µM -0.698972580844613 0.23841135450816 no 2589 0.242284583231007 3729 6710616
SGTC_1394 3474-0001 65.7 µM -0.699037362756448 0.238390756666165 no 2590 0.242264340739855 3644 5017666 YIL048W NEO1
SGTC_404 fumagillin 50 µM -0.699489319198466 0.238247081212685 no 2591 0.24212314281049 3661 12015870 A methionine aminopeptidase binder.
SGTC_2841 9004761 38.96 µM -0.70056582330076 0.237905055265157 no 2592 0.241787006666116 3605 2991039
SGTC_3013 9080133 71.4286 µM -0.701444812831453 0.237625983258263 no 2593 0.241512731952218 3741 17050193
SGTC_644 1498-1197 63.3 µM -0.702047552906784 0.237434722067526 no 2594 0.241324754192247 3710 6741615
SGTC_3185 9108267 49.47 µM -0.703023552483736 0.237125197655288 no 2595 0.241020535903671 3643 4910486
SGTC_216 k038-0035 28.382 µM -0.703335721229868 0.237026244583336 no 2596 0.240923277192016 3607 4444231 YPR107C YTH1
SGTC_598 3937-0236 20.2 µM -0.705625021798104 0.236301262634847 no 2597 0.240210679737502 3737 1379313
SGTC_492 tmb-8 126 µM -0.706396602178409 0.236057191846956 no 2598 0.239970766661491 3578 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_731 3966-0296 387 µM -0.706464438687338 0.236035740053138 no 2599 0.239949680015337 3716 660956
SGTC_2390 9097792 176.6 µM -0.707997270443387 0.235551302415696 no 2600 0.239473476268743 3690 4497149
SGTC_67 0335-0847 266 µM -0.709488033930188 0.235080686713386 no 2601 0.23901083728271 3781 4552207 YOR254C SEC63
SGTC_2477 5967686 25.23 µM -0.7107529393792 0.234681779267869 no 2602 0.238618673903968 3707 776118
SGTC_2387 9077560 195.08 µM -0.710773898342684 0.234675172689281 no 2603 0.238612178885106 3688 5303272
SGTC_992 3909-8734 162 µM -0.711559425929405 0.234427636823469 no 2604 0.238368819811834 3705 4288319
SGTC_2674 ligustilide 100 µM -0.71160894918075 0.234412035873163 no 2605 0.238353481899063 3680 5319022 A signalling regulator.
SGTC_1313 1220-0047 237 µM -0.711918209679027 0.234314624780458 no 2606 0.238257712641945 3709 3528706
SGTC_1851 st056236 18.9 µM -0.711918277804901 0.23431460332459 no 2607 0.238257691547605 3696 5393171
SGTC_8 0354-0001 70 µM -0.712683091443192 0.234073798034691 no 2608 0.23802094088846 3730 4993152
SGTC_2355 9061122 103.12 µM -0.712697609915055 0.234069228149256 no 2609 0.238016447893721 3701 5302957
SGTC_2246 7293507 91.5585 µM -0.712783941698677 0.234042055072925 no 2610 0.237989731975323 3745 887656
SGTC_2515 chrysin 20.77 µM -0.71301859691028 0.233968205773595 no 2611 0.237917124737755 3712 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1256 0570-0116 285 µM -0.715840039039082 0.233081269666289 no 2612 0.237045063101125 3707 410638
SGTC_2749 bexarotene 57.39 µM -0.716289708040393 0.232940086379318 no 2613 0.236906240235754 3720 82146 An retinoic acid receptor inhibitor.
SGTC_2356 9061756 188.97 µM -0.716370898255862 0.232914600022574 no 2614 0.236881179766969 3695 20104043
SGTC_1625 st003711 30.1 µM -0.718003150385131 0.232402549763482 no 2615 0.236377672163375 3737 24207034 YER133W GLC7
SGTC_2059 5238311 157 µM -0.718394128407109 0.232279989919286 no 2616 0.236257153072663 3711 703021
SGTC_274 sirtinol 40.1 µM -0.721126213098384 0.231424567967653 no 2617 0.235415932260007 3726 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3118 9124250 49.47 µM -0.721193511428863 0.231403518898503 no 2618 0.235395231692361 3663 1504786
SGTC_1413 3910-0535 34.4 µM -0.722360615059682 0.231038650790164 no 2619 0.235036397362781 3712 2876951
SGTC_634 1611-4317 11.2 µM -0.722711688513848 0.230928958607236 no 2620 0.234928516478867 3730 2843522
SGTC_2466 5983409 37.09 µM -0.723126510005105 0.230799385964981 no 2621 0.234801081822075 3724 2879657
SGTC_1206 3978-0017 132 µM -0.723348650913882 0.230730015263206 no 2622 0.234732855047857 3760 3873677
SGTC_2523 spermine 47.74 µM -0.72791239514882 0.229307418471882 no 2623 0.233333607510666 3683 1103 A DNA binding polyamine.
SGTC_1355 1499-0035 1.68 µM -0.7294759482157 0.228821165674719 no 2624 0.232855287523135 3729 1548538
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.729969933262022 0.22866766058312 no 2625 0.232704281620999 3788 6708561
SGTC_2935 9038016 29.96 µM -0.731529286651384 0.228183473497158 no 2626 0.232227961360734 3715 6463195
SGTC_3287 9117173 37.0625 µM -0.731934158691173 0.228057853012302 no 2627 0.232104377881531 3716 2789709
SGTC_184 1494-0393 24.714 µM -0.732780909036764 0.22779525580596 no 2628 0.231846033482668 3719 3090647
SGTC_3 0833-0587 95.581 µM -0.733012245301009 0.227723542593798 no 2629 0.231775480418442 3673 5382644
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.733962638896118 0.227429058190903 no 2630 0.231485754390564 3741 5377381
SGTC_875 0709-0210 25.7 µM -0.734580862429685 0.227237613621575 no 2631 0.231297398340615 3730 6251364
SGTC_1236 0330-0013 258 µM -0.736396172072592 0.226675993964419 no 2632 0.230744816771689 3739 4617066
SGTC_3111 9122088 49.47 µM -0.73706225151347 0.226470119230933 no 2633 0.230542246785709 3639 16876704
SGTC_108 0509-0257 621.132 µM -0.737235121794686 0.226416704993501 no 2634 0.23048968923008 3718 536624
SGTC_1047 2043-3044 82 µM -0.737256807589786 0.226410004921195 no 2635 0.230483096595171 3734 669592
SGTC_431 k089-0097 107 µM -0.737745732881742 0.226258975631053 no 2636 0.230334487832151 3694 5499420
SGTC_111 0083-0039 52.457 µM -0.738510464652964 0.226022863740388 no 2637 0.230102155210917 3642 759313
SGTC_1360 1598-0022 39.8 µM -0.739936536057859 0.225582934670365 no 2638 0.229669251896858 3797 761525
SGTC_904 1141-0088 396 µM -0.740847012425544 0.225302315258062 no 2639 0.229393103219979 3715 1378119
SGTC_571 k831-0106 44.2 µM -0.741033349599463 0.225244908351418 no 2640 0.229336609861293 3696 4783639
SGTC_2620 irigenin 100 µM -0.742641545272234 0.224749798563107 no 2641 0.22884936433904 3762 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2114 5491910 81.25 µM -0.742948231527531 0.224655450215233 no 2642 0.22875651161762 3809 2849228
SGTC_1274 0865-0114 173 µM -0.743034563925507 0.224628895141207 no 2643 0.228730377326269 3764 870624
SGTC_671 0560-0003 407 µM -0.74417927348267 0.224276961077996 no 2644 0.228384012704764 3679 3238678
SGTC_517 1365-0151 113 µM -0.744855666042676 0.224069155480623 no 2645 0.228179489396778 3809 768657
SGTC_2279 7948423 32.93 µM -0.745949870703136 0.2237332186986 no 2646 0.227848848844035 3720 1247112
SGTC_418 lividomycin a 100 µM -0.746226913706725 0.223648207906458 no 2647 0.227765176352947 3743 72394 An antibiotic.
SGTC_3350 9150499 3.57 µM -0.746834575682692 0.223461810848022 no 2648 0.227581710942577 3725 4910996 YPR165W RHO1
SGTC_844 0330-0132 15.3 µM -0.746889142900715 0.223445076971513 no 2649 0.227565240071224 3756 2828079
SGTC_905 2-aminofluorene 215 µM -0.747057147758717 0.223393560175051 no 2650 0.227514532769319 3772 1539 An established DNA mutagen. YPR165W RHO1
SGTC_783 0848-0141 92.7 µM -0.748490795565564 0.222954223219451 no 2651 0.227082087461802 3737 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_493 zm226600 134 µM -0.749720677369728 0.222577722243223 no 2652 0.226711475686669 3760 5240098 A potassium channel opener. YCR052W RSC6
SGTC_563 tetrahydrosecaminediol 614 µM -0.74993669652431 0.222511630226423 no 2653 0.226646415875512 3799 334274 A psychoactive constituent of the cannabis plant.
SGTC_427 1354-0053 47.3 µM -0.751918789407668 0.221905722796294 no 2654 0.226049948984201 3857 6813657
SGTC_1659 st012954 42.1 µM -0.752056111171095 0.221863779734995 no 2655 0.226008657936491 3741 24207262
SGTC_1252 0493-0875 34.8 µM -0.752640257725381 0.221685410735359 no 2656 0.225833059554714 3761 3960963
SGTC_2151 5563267 85.4165 µM -0.754596671926734 0.221088617279396 no 2657 0.225245510587975 3796 5310824
SGTC_1721 st082152 9.2685 µM -0.755578322876308 0.220789516734372 no 2658 0.224951028352047 3709 5296051
SGTC_2140 5586273 200 µM -0.756132008118684 0.220620915891391 no 2659 0.224785026438374 3734 854421
SGTC_91 0417-1751 58.384 µM -0.75655899393268 0.220490946254632 no 2660 0.224657058084849 3860 6795624
SGTC_2469 5655019 90.81 µM -0.756594456363259 0.220480153866898 no 2661 0.22464643179464 3823 2788239
SGTC_70 0141-0289 43.283 µM -0.757048253131001 0.220342075262917 no 2662 0.224510477109692 3797 352408
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.757689959767705 0.220146905191009 no 2663 0.22431830550931 3779 165506
SGTC_532 1548-0774 215 µM -0.758120377510597 0.220016052563496 no 2664 0.224189460838916 3860 5932993
SGTC_722 3534-0461 190 µM -0.75816270056579 0.220003188210799 no 2665 0.224176793788739 3768 658262
SGTC_2308 7584454 197.62 µM -0.759039118918962 0.219736892480784 no 2666 0.223914578118989 3790 893577
SGTC_1925 st057770 10.1 µM -0.760760908163707 0.219214273897361 no 2667 0.223399943749175 3762 5989122
SGTC_211 3455-0679 143.504 µM -0.762294921010499 0.218749253982893 no 2668 0.222942002270628 3787 748649
SGTC_1623 st003709 20.3 µM -0.764658002600464 0.218034022556325 no 2669 0.222237610269765 3764 16192618
SGTC_736 0958-0254 92.6 µM -0.764659014008847 0.218033716723323 no 2670 0.222237309059303 3837 6812352
SGTC_2533 agelasine 13.65 µM -0.764664083799499 0.218032183707033 no 2671 0.22223579921377 3806 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2748 diazoxide 86.69 µM -0.764754204426455 0.218004933837906 no 2672 0.222208961167934 3771 3019 A potassium channel activatior.
SGTC_753 1322-0200 289 µM -0.76518386377528 0.217875044285701 no 2673 0.222081033458449 3805 5403907
SGTC_2081 5214970 32.255 µM -0.765277706654211 0.217846680751893 no 2674 0.222053098070446 3705 2063512
SGTC_1138 3761-0006 1.03 µM -0.765627651277957 0.217740930545265 no 2675 0.221948943350343 3744 12061087
SGTC_1565 sinapyl alcohol 95.1 µM -0.765915124795841 0.217654080721747 no 2676 0.221863402905749 3789 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1793 st048256 72.231 µM -0.766267535699478 0.217547639670399 no 2677 0.22175856542631 3665 672022
SGTC_1434 4073-0095 163 µM -0.766320465856393 0.217531655412189 no 2678 0.221742821865105 3750 24133745
SGTC_1821 st053465 65.6 µM -0.767220313898066 0.217260016080838 no 2679 0.221475268526268 3778 675086
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.767440845345232 0.217193473615731 no 2680 0.221409725706956 3813 521171
SGTC_2249 haloperidol 116.36 µM -0.768111182269536 0.216991280557054 no 2681 0.221210567023055 3784 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_682 0kpi-0099 17 µM -0.768662118139251 0.216825183795232 no 2682 0.221046959427124 3809 1714895 YML126C ERG13
SGTC_2845 9003024 42.97 µM -0.770734359909681 0.216201100633968 no 2683 0.220432200633468 3791 2990173
SGTC_65 0798-0905 34.986 µM -0.771274145243809 0.216038708021006 no 2684 0.220272226967457 3847 3602145
SGTC_995 3931-2021 34.6 µM -0.771545759908975 0.215957020386296 no 2685 0.22019175497551 3796 730143
SGTC_503 tyrphostin 8 294 µM -0.772556156182072 0.215653302626405 no 2686 0.219892550264541 3747 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1318 1280-3875 124 µM -0.772559761407002 0.215652219365652 no 2687 0.219891483081261 3804 373245
SGTC_662 k832-1615 104 µM -0.773438841159874 0.215388176747652 no 2688 0.219631355263008 3838 5878478
SGTC_1899 st063254 59.6 µM -0.775951575810908 0.214634480503996 no 2689 0.218888789103789 3728 3093813
SGTC_325 2810-4341 181 µM -0.776281144832625 0.214535739917627 no 2690 0.218791501753958 3782 774970
SGTC_1554 st069299 38.7 µM -0.779891885925255 0.213455673973592 no 2691 0.217727257443309 3753 24207999
SGTC_852 0418-0143 439 µM -0.781373238004907 0.213013481735462 no 2692 0.217291503231624 3851 5369229
SGTC_1051 3253-3903 78 µM -0.782848957803669 0.212573502646686 no 2693 0.216857907027513 3800 5509239
SGTC_1007 4101-0031 70 µM -0.783951525007902 0.212245123998303 no 2694 0.216534277301996 3740 1146276
SGTC_767 0929-0023 86 µM -0.784543299187198 0.212068997674564 no 2695 0.216360692792417 3859 1204563
SGTC_3005 9076496 71.4286 µM -0.785408002389127 0.21181179480405 no 2696 0.216107195181761 3817 21368410
SGTC_780 0109-0199 192 µM -0.785687542669152 0.21172868560521 no 2697 0.21602528156721 3836 610414
SGTC_2787 5284540 71.43 µM -0.787387667216356 0.211223638322881 no 2698 0.215527482005592 3854 736958
SGTC_1273 0849-0096 14.1 µM -0.787546140394759 0.211176597499879 no 2699 0.215481114692041 3830 5286025
SGTC_394 menadione 8.33 µM -0.787873602180182 0.211079413928675 no 2700 0.215385321711816 3765 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2484 5809818 12.04 µM -0.789963430855384 0.210459815755155 no 2701 0.214774562646325 3821 2870548
SGTC_2490 carminic acid 95.39 µM -0.792337596553191 0.209757213499681 no 2702 0.214081927635256 3734 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1637 st007924 17.4 µM -0.792837809716753 0.209609358252135 no 2703 0.213936162281317 3786 683336
SGTC_301 4119-0100 24.5 µM -0.792939430909953 0.209579328097721 no 2704 0.213906556270987 3841 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_822 1487-0950 154 µM -0.79325300546875 0.209486679399854 no 2705 0.21381521544794 3809 1958375
SGTC_914 3820-6779 408 µM -0.79514800578369 0.20892729586624 no 2706 0.213263706273663 3795 2893481
SGTC_249 wiskostatin 11.211 µM -0.796247656593828 0.208603094722713 no 2707 0.2129440514006 3812 2775510 A n-wasp and actin depolymerizer.
SGTC_1653 st012112 65 µM -0.797493911580147 0.208236030212212 no 2708 0.212582118715333 3811 720429
SGTC_2452 5863136 48.41 µM -0.798072868418065 0.208065637442999 no 2709 0.212414102545811 3802 2184096
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.799316192460901 0.207699993043613 no 2710 0.212053546028694 3839 689007
SGTC_1142 3253-1408 9.78 µM -0.799445528504863 0.207661978912516 no 2711 0.212016059913771 3775 256655
SGTC_2237 6667747 47.222 µM -0.80000404736616 0.207497867635396 no 2712 0.211854226097507 3811 729940 YDL015C TSC13
SGTC_2790 5423970 71.43 µM -0.800257361498945 0.2074234608559 no 2713 0.211780850806524 3896 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_687 k029-0044 34.9 µM -0.800416460315088 0.20737673631116 no 2714 0.211734773646858 3863 5829338
SGTC_1111 tnp00062 510.699 nM -0.800445291261919 0.207368269831435 no 2715 0.21172642444435 3903 676306
SGTC_11 0438-0307 1.3 µM -0.800465011580389 0.207362478891436 no 2716 0.211720713715039 3826 4011476
SGTC_2869 9037858 32.47 µM -0.801211812900855 0.207143248466826 no 2717 0.211504516817092 3775 27187042
SGTC_3249 9135183 49.47 µM -0.802536768326463 0.206754633135989 no 2718 0.211121264199193 3831 4902779
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.802812362708358 0.206673854338955 no 2719 0.211041597761387 3823 6857784
SGTC_3263 9137018 49.47 µM -0.803607769484677 0.206440819430093 no 2720 0.210811767301904 3842 43844957
SGTC_542 3381-0244 89.3 µM -0.803780870237001 0.206390125738943 no 2721 0.210761769802372 3882 1112843
SGTC_978 1416-0512 87.4 µM -0.805887960551153 0.205773642108122 no 2722 0.210153726889245 3902 6814003
SGTC_3295 9122362 53.5725 µM -0.806582883041196 0.205570564462624 no 2723 0.20995341932705 3886 4730473
SGTC_2986 9022445 71.43 µM -0.806706055107611 0.205534582228053 no 2724 0.209917927370009 3783 6459286
SGTC_2298 7976326 193.81 µM -0.806786841707126 0.205510984083367 no 2725 0.209894650674789 3720 2235818
SGTC_1044 1222-0021 1.78 µM -0.807238217226839 0.20537916478345 no 2726 0.2097646257081 3840 4306703
SGTC_1910 st062352 60.4 µM -0.807476623054218 0.205309561231866 no 2727 0.209695968725324 3794 2245730
SGTC_2483 5729050 27.16 µM -0.808717835349416 0.204947410695664 no 2728 0.209338733407922 3836 2865180
SGTC_761 k216-0224 480 µM -0.80945609552809 0.204732187560407 no 2729 0.209126423527352 3848 1340404
SGTC_2828 7998861 71.43 µM -0.810955887950175 0.2042953710317 no 2730 0.20869550176304 3755 2988188
SGTC_1784 st039334 36.3 µM -0.811094651748971 0.204254983956914 no 2731 0.20865565848654 3894 3496984
SGTC_2045 5106652 78.05 µM -0.81528911642985 0.203036434090531 no 2732 0.207453418561268 3837 673349
SGTC_1940 st075990 51.1 µM -0.817570930636014 0.202375362584571 no 2733 0.206801115995119 3933 1084979
SGTC_1698 5-fluorocytosine 1.055 µM -0.818986208246211 0.201965985644679 no 2734 0.20639714119002 3892 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2969 9091408 28.7 µM -0.819935744290754 0.201691605104806 no 2735 0.206126369281696 3816 4286311
SGTC_39 0986-0283 58.349 µM -0.819962274113129 0.201683942182055 no 2736 0.206118807001554 3939 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1557 sumaresinolic acid 42.3 µM -0.820763984405861 0.201452456970849 no 2737 0.20589035847055 3807 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_23 0213-0011 39.996 µM -0.821290419230191 0.201300541224242 no 2738 0.205740431822209 3870 627608
SGTC_1747 st037496 66.6 µM -0.822856592814104 0.200848989483865 no 2739 0.205294774765619 3868 723305
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.823241377409125 0.200738143297216 no 2740 0.205185371544493 3817 279621
SGTC_1615 st002656 86.5 µM -0.825765095028412 0.200012038158437 no 2741 0.204468679009098 3864 1584458
SGTC_699 0375-0592 111 µM -0.82795587401894 0.199383005775325 no 2742 0.203847745046344 3897 762578
SGTC_1060 3448-7350 82 µM -0.829354609562688 0.198982014379693 no 2743 0.203451889005938 3810 570178
SGTC_3281 9140613 49.47 µM -0.829699051425984 0.198883343944031 no 2744 0.203354478954441 3886 16013766
SGTC_185 k048-0037 25.491 µM -0.83075430536831 0.198581234569472 no 2745 0.203056220620261 3906 6827589
SGTC_901 1112-0062 60.1 µM -0.831307170917029 0.198423064870842 no 2746 0.202900062316528 3874 1908457
SGTC_79 0052-0007 94.094 µM -0.831949976624197 0.198239259727978 no 2747 0.202718590396425 3869 2801472
SGTC_1798 st045719 60.953 µM -0.832292803745174 0.198141273095889 no 2748 0.20262184577277 3784 3980186
SGTC_2093 5331342 194.4 µM -0.834927582640138 0.197389178654591 no 2749 0.201879241758017 3954 33839
SGTC_2272 7805186 180 µM -0.83548021557503 0.197231649566782 no 2750 0.201723690906589 3893 2956062 YPR165W RHO1
SGTC_2334 9017922 200 µM -0.837557372407485 0.196640232500181 no 2751 0.201139671100597 3958 3163164
SGTC_745 0469-0705 296 µM -0.838103012197927 0.196485053928748 no 2752 0.200986425666417 3954 3486736
SGTC_1371 2421-0008 32.7 µM -0.839448577265467 0.196102695906212 no 2753 0.200608817011114 3888 2827552
SGTC_1039 k821-0043 94 µM -0.839739215484615 0.196020166965881 no 2754 0.200527310592684 3869 15992768
SGTC_969 1313-0238 134 µM -0.840420508043522 0.195826791340868 no 2755 0.200336327254453 3906 5212874
SGTC_1911 st060208 74.3 µM -0.840780175119676 0.195724751441633 no 2756 0.200235547668664 3944 688783
SGTC_3271 9137798 49.47 µM -0.841535188572641 0.195510654205102 no 2757 0.200024090195751 3791 6498326
SGTC_3283 9109332 35.8195 µM -0.841666956528771 0.195473303684421 no 2758 0.199987199559767 3741 17027281
SGTC_2069 5228469 200 µM -0.841976670489124 0.195385530227821 no 2759 0.199900506082658 3895 2835210
SGTC_2026 5148700 152 µM -0.843454900739536 0.194966927229551 no 2760 0.199487039222206 3878 79838
SGTC_2625 euphol 100 µM -0.843573884171108 0.194933257410614 no 2761 0.199453781484453 3922 6708538 A triterpene alcohol.
SGTC_630 4356-0227 183 µM -0.844247498014534 0.194742705481192 no 2762 0.199265558782201 3871 779312
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.845109958401382 0.194498898110763 no 2763 0.19902472437253 3682 4000243
SGTC_97 0535-0701 19.132 µM -0.847465318182875 0.193834012794737 no 2764 0.198367905175344 3823 2832013 YGL099W LSG1
SGTC_3262 9137218 49.47 µM -0.847696084288883 0.193768945332989 no 2765 0.198303623820808 3712 17650664
SGTC_1855 st056195 39.6 µM -0.84864808775692 0.193500656556538 no 2766 0.198038570188884 3829 4028379
SGTC_2953 9074162 66.49 µM -0.850056946100547 0.193104035296689 no 2767 0.197646713350541 3858 16451992
SGTC_804 1595-0054 20.9 µM -0.850103978225828 0.193090803397639 no 2768 0.197633640024746 3852 761523 Stimulates phospholipase C.
SGTC_650 1328-0195 38 µM -0.85321322220508 0.192217284910587 no 2769 0.196770536146484 3838 2780821
SGTC_1817 st052116 64.4 µM -0.853445249934362 0.192152195551635 no 2770 0.196706218568984 3892 4361398
SGTC_3180 9109287 49.47 µM -0.855058425267749 0.191700033945626 no 2771 0.196259402018459 3966 18891271
SGTC_1429 4049-0205 9.46 µM -0.856243539796326 0.191368270291242 no 2772 0.195931541966443 3921 22774478
SGTC_398 bronopol 33.3 µM -0.856342907738068 0.191340469001475 no 2773 0.195904067090964 3812 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2630 antimycin a 100 µM -0.857540360545014 0.191005638804236 no 2774 0.195573159588485 3885 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3031 9088762 49.47 µM -0.859586020518629 0.190434466000493 no 2775 0.195008641861101 3882 205253
SGTC_3304 9125678 46.087 µM -0.86285368461979 0.189524273587645 no 2776 0.194108959111154 3867 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2715 st079500 56.4 µM -0.864597724512395 0.189039576970155 no 2777 0.193629810948278 3860 28246688
SGTC_1559 coumarin 343 70.1 µM -0.865190611853422 0.188874978134912 no 2778 0.193467088675183 3931 108770 A hepatotoxic, DNA x-linker.
SGTC_2859 9028643 45.46 µM -0.86757935299279 0.188212705050451 no 2779 0.192812326731476 3833 17151580
SGTC_1059 3448-6867 171 µM -0.868752336478695 0.187888023252871 no 2780 0.19249130421812 3856 3934407
SGTC_501 nsc-95397 161 µM -0.86893266043074 0.187838140276495 no 2781 0.192441982091815 3975 262093
SGTC_43 0570-0105 72.5 µM -0.869064813538779 0.187801587984136 no 2782 0.192405840539973 3935 1114046 YDL195W SEC31
SGTC_3303 9125618 40.5795 µM -0.869610788284402 0.1876506231331 no 2783 0.192256570042559 3965 22695467
SGTC_2262 9014885 67.46 µM -0.872007302780692 0.186988861630141 no 2784 0.1916021968107 3866 6457424
SGTC_55 0767-0285 6.563 µM -0.872557341626898 0.186837180624479 no 2785 0.19145220028315 3856 3116166
SGTC_831 k061-1017 217 µM -0.87356917358459 0.186558352573051 no 2786 0.191176459973116 3989 1240153
SGTC_490 phenamil 164 µM -0.874442982532549 0.186317766649634 no 2787 0.190938529166288 3911 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2357 9067248 200 µM -0.874455394542712 0.186314350634598 no 2788 0.190935150789545 3947 9150235
SGTC_500 h-89 112 µM -0.875222336896116 0.18610334917897 no 2789 0.190726470872514 3971 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_534 k292-0788 63.4 µM -0.876176111389701 0.185841153129356 no 2790 0.190467150526144 3924 4146317
SGTC_1332 1480-0653 17.5 µM -0.876820626149763 0.185664103479886 no 2791 0.190292036998805 3929 5749438
SGTC_1703 st026983 48.3 µM -0.878314699573764 0.185254080816657 no 2792 0.189886480394836 3943 1104023
SGTC_608 k048-0125 159 µM -0.878330999248113 0.18524961075528 no 2793 0.189882058885652 3975 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_734 2023-0417 80 µM -0.878482629733547 0.185208030460878 no 2794 0.189840930079939 3965 3935732
SGTC_569 4130-2812 160 µM -0.878622714229019 0.185169621473092 no 2795 0.189802937918994 3760 743552
SGTC_3238 9133470 49.47 µM -0.880903816362584 0.184544875131703 no 2796 0.189184940850829 3936 3534688
SGTC_2075 5212009 200 µM -0.88167516755029 0.184333915048271 no 2797 0.188976246730014 3828 780898
SGTC_2100 5377183 190 µM -0.881705200775916 0.184325704170953 no 2798 0.188968123913414 3971 2844202
SGTC_795 0685-0265 78 µM -0.883095223870151 0.183945930448851 no 2799 0.18859241224039 3976 302754
SGTC_466 geldanamycin 89.2 µM -0.884016618562247 0.183694461285861 no 2800 0.188343620934055 3852 5288382 HSP90 inhibitor.
SGTC_1672 st016598 6.51 µM -0.884214486843729 0.183640486568731 no 2801 0.188290219752327 3993 4665860 YNL267W PIK1
SGTC_1571 st070080 73.4 µM -0.884318225976678 0.183612192448479 no 2802 0.188262226111163 4008 4315245
SGTC_3082 9117008 49.47 µM -0.884508555392194 0.1835602885011 no 2803 0.188210873063754 4019 41448529
SGTC_1756 st041558 35.5 µM -0.884789378567853 0.183483723075862 no 2804 0.188135119554368 4030 3955792
SGTC_367 0335-0881 7.1 µM -0.884842758709158 0.183469171424938 no 2805 0.188120722112825 3945 23828853
SGTC_2855 9016525 58.44 µM -0.885295282845054 0.183345840343221 no 2806 0.187998696742098 3908 43811474
SGTC_1345 1488-0192 31.4 µM -0.886188515399499 0.183102550201313 no 2807 0.187757975625716 3968 658348
SGTC_148 3253-0744 288.01 µM -0.88657354916799 0.18299774052996 no 2808 0.187654269950698 3867 6893655
SGTC_1953 st076800 12.1 µM -0.886619450724404 0.182985248209324 no 2809 0.1876419091057 3974 297591
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.887412072401798 0.182769616492806 no 2810 0.187428543103624 4014 1273210
SGTC_33 0986-0033 35.816 µM -0.887469767631566 0.182753926775082 no 2811 0.187413017969444 3861 2848082
SGTC_462 ag-879 158 µM -0.888530955600135 0.182465495879671 no 2812 0.187127606063637 3985 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2677 mitomycin C 100 µM -0.889211548445696 0.182280660494702 no 2813 0.186944698728091 3969 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2513 baicalein 25.65 µM -0.891557233221805 0.181644516497949 no 2814 0.186315150860517 3966 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1337 1486-1011 40.3 µM -0.892611343825837 0.181359097243829 no 2815 0.186032671092768 3946 X1337
SGTC_2353 9059630 146.67 µM -0.893847192602674 0.18102482695146 no 2816 0.185701827586505 4011 4779114
SGTC_2769 toremifene 3.73 µM -0.894307499057627 0.180900422769213 no 2817 0.185578694375092 3957 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2678 equilin 100 µM -0.895501136278717 0.180578075508162 no 2818 0.185259629325589 3966 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.895662529001945 0.180534518318878 no 2819 0.185216514422072 3947 641818 YHR062C RPP1
SGTC_582 0987-0078 156 µM -0.899822688434084 0.179414035987997 no 2820 0.184107309103541 3995 1625765
SGTC_1086 cerivastatin 2.18 µM -0.901803704583257 0.178882016252611 no 2821 0.183580575762022 3935 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_570 0987-0065 62.6 µM -0.901957266478942 0.178840817330709 no 2822 0.183539784374193 3770 3104428
SGTC_2863 9028737 58.44 µM -0.905188502247811 0.177975298686188 no 2823 0.182682766013891 3952 6460917
SGTC_1430 4049-0248 69.1 µM -0.906602042819774 0.177597499673526 no 2824 0.182308640548776 3977 22774488
SGTC_1901 st060216 58.6 µM -0.907228964702924 0.177430103493219 no 2825 0.182142864869803 3957 688792
SGTC_1758 st042942 75.2445 µM -0.907279713297556 0.17741655732706 no 2826 0.182129449645896 3892 669317
SGTC_2724 maprotiline 69.64 µM -0.907870189561748 0.177258991311894 no 2827 0.181973404594475 3897 4011 A tricyclic antidepressant.
SGTC_2797 7859098 81.82 µM -0.90890399642405 0.176983337341465 no 2828 0.181700402039417 3976 972681
SGTC_2476 5806916 10.51 µM -0.908935202668344 0.176975020731038 no 2829 0.181692165236608 3858 2870194
SGTC_1848 st056003 16.4 µM -0.913139655865224 0.175856772745966 no 2830 0.180584548091879 4015 146492
SGTC_2010 4012422 159 µM -0.913964960111734 0.175637795200553 no 2831 0.180367628952526 3988 952393
SGTC_1655 st012546 55.1 µM -0.914389716359265 0.175525162220246 no 2832 0.180256051740938 3980 720985 YLR208W SEC13
SGTC_1457 k015-0032 57.3 µM -0.915013489109642 0.175359838859527 no 2833 0.180092274359885 3992 4302660
SGTC_2491 paeonol 100 µM -0.915214452493662 0.175306596998936 no 2834 0.180039529443326 3844 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2102 5377816 72.7585 µM -0.917084322630401 0.174811697896775 no 2835 0.179549227773161 4047 1379702
SGTC_2767 sibutramine 71.45 µM -0.91763569917048 0.174665934363036 no 2836 0.17940481080587 3958 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1070 indatraline 8.81 µM -0.918096007976662 0.174544304886016 no 2837 0.179284302318524 3994 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1531 st059297 52.4 µM -0.918484515887848 0.174441689552771 no 2838 0.179182630872567 4001 7566702
SGTC_1213 1315-0166 115 µM -0.918553222319168 0.174423546334638 no 2839 0.179164654364112 4095 768401
SGTC_2545 solidagenone 89.61 µM -0.919423639243364 0.174193800260526 no 2840 0.178937014710063 3789 6708572 An anti ulcer agent
SGTC_2546 rhodinyl acetate 100 µM -0.920711768458946 0.173854152341654 no 2841 0.178600465159632 3920 6708682
SGTC_538 2922-0838 53.3 µM -0.920991424697857 0.173780469568144 no 2842 0.178527452067775 3960 777039
SGTC_395 anisomycin 6.25 µM -0.921306683393827 0.173697430214496 no 2843 0.178445166376244 4015 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_449 xestospongin c 11.1929 µM -0.921823981864195 0.173561228151678 no 2844 0.178310198046826 4003 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3050 9093513 49.47 µM -0.922034496856165 0.173505820084245 no 2845 0.178255291006649 3973 25236664
SGTC_3183 9108214 49.47 µM -0.922615735532248 0.173352895083717 no 2846 0.178103746231107 3937 4974831
SGTC_87 0100-0052 35.5 µM -0.922725555474776 0.173324010889028 no 2847 0.178075122302139 4062 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2003 4023581 200 µM -0.923986866279464 0.172992488062392 no 2848 0.177746576948472 4044 16641307
SGTC_2955 9076254 12.21 µM -0.925242871190817 0.172662761566252 no 2849 0.177419793933832 3934 16459619
SGTC_686 1319-0111 510 µM -0.925260879134952 0.172658037034842 no 2850 0.177415111448832 4021 4562600
SGTC_330 1488-0319 80.1 µM -0.926482664997732 0.172337684025037 no 2851 0.177097600888681 4043 6846614
SGTC_3212 9128307 49.47 µM -0.931364768313974 0.171061381496034 no 2852 0.175832454510593 3968 27243542
SGTC_1579 chlormadinone acetate 49.4 µM -0.931466253743294 0.171034914999703 no 2853 0.175806216496617 4041 45114258 A steroidal progestin.
SGTC_2167 5876490 200 µM -0.933187417003921 0.170586449901406 no 2854 0.17536160518555 4158 686534
SGTC_1393 3470-5649 58.2 µM -0.933866685739548 0.170409667493574 no 2855 0.175186332683525 3992 4108395
SGTC_2377 9073351 62.6 µM -0.938783083242434 0.169133655129347 no 2856 0.173921063053912 3979 7337946 YHR072W ERG7
SGTC_2791 5663188 71.43 µM -0.939897537436949 0.168845262504922 no 2857 0.173635060310309 4069 54690634
SGTC_317 4495-0002 170 µM -0.944077119665245 0.167766508408589 no 2858 0.172565120261905 4054 15991618
SGTC_2519 cryptotanshinone 88.04 µM -0.946274930115697 0.167201035834232 no 2859 0.17200418837733 4012 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3017 9080681 49.47 µM -0.948270611617791 0.166688634464462 no 2860 0.1714958539896 4048 16451914
SGTC_3179 9107801 49.47 µM -0.948482358013026 0.166634327025014 no 2861 0.171441974935386 4030 4818259
SGTC_1560 lithocholic acid 53.1 µM -0.948937472777152 0.166517640584808 no 2862 0.1713262072084 3880 9903 A bile acid which acts as a detergent.
SGTC_683 panaxydol 45 µM -0.949462139998038 0.166383187126193 no 2863 0.17119280942381 4011 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_474 dl-dihydrosphingosine 5 µM -0.949867485208202 0.166279359647116 no 2864 0.171089795010572 4042 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1124 fisetin 1.16336 µM -0.951186043882925 0.165941905877715 no 2865 0.170754970883328 4059 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1235 benzylparaben 21.5 µM -0.956394371850728 0.164613288443409 no 2866 0.169436513556684 4048 7180
SGTC_290 2043-6722 48.1 µM -0.95874565388176 0.164015753230581 no 2867 0.168843446610679 4052 773758 YLR208W SEC13
SGTC_365 0121-0052 13.6 µM -0.959082343126236 0.163930305153058 no 2868 0.168758632339582 4090 3101739
SGTC_729 4092-0585 94.1 µM -0.960319216563609 0.163616648113286 no 2869 0.168447290733461 4057 2169061
SGTC_2864 9034755 47.6 µM -0.963222550039303 0.162881927631513 no 2870 0.167717925469354 3991 4930451
SGTC_435 c-PAF 6.7 µM -0.963773149149133 0.162742834839362 no 2871 0.167579835643032 4048 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.963860712449428 0.16272072164969 no 2872 0.167557881587329 3886 6708630 An antioxidant.
SGTC_1296 1068-0102 11.9 µM -0.965529422804041 0.162299679954619 no 2873 0.167139853118971 4057 767053
SGTC_2285 7945142 200 µM -0.96643403274323 0.162071729440774 no 2874 0.166913520663629 4106 2970608
SGTC_631 k072-0230 41.5 µM -0.96685176474664 0.161966536552692 no 2875 0.166809071309315 4074 5773147
SGTC_808 0711-0032 135 µM -0.967731860382365 0.161745057274719 no 2876 0.166589150985139 3966 4252555
SGTC_1427 4048-4900 550 nM -0.972578369284109 0.160528953516508 no 2877 0.165381448759084 4044 24132586
SGTC_1813 st051246 8.6015 µM -0.972846180488701 0.16046192795219 no 2878 0.165314878417716 3973 5291959
SGTC_874 0599-0792 117 µM -0.973445140773839 0.16031209133011 no 2879 0.165166056483102 4085 765305
SGTC_2543 pimpinellin 60.67 µM -0.974325719932818 0.160091970685894 no 2880 0.164947419033745 3892 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1904 st060225 78 µM -0.975384009840054 0.159827688812564 no 2881 0.164684906179347 3998 66595
SGTC_2813 7971799 71.43 µM -0.977500502423952 0.159300003486403 no 2882 0.164160714575159 4110 2234054
SGTC_2741 miltefosine 3.04 µM -0.978570704558464 0.159033614772234 no 2883 0.16389607006237 4038 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_611 3453-1652 23.7 µM -0.981034012099196 0.158421571755501 no 2884 0.163287984633198 4076 1560575
SGTC_135 0933-0004 26.348 µM -0.984850289486889 0.157476419795481 no 2885 0.162348807096796 4057 21230617 YGL099W LSG1
SGTC_205 1486-1330 71.903 µM -0.986899783987591 0.156970367798997 no 2886 0.161845885078658 4096 4118834
SGTC_3038 9091290 49.47 µM -0.98767200819048 0.156779971447716 no 2887 0.161656653855178 4108 25236843
SGTC_601 0986-0029 62.9 µM -0.991035845361424 0.155952371537806 no 2888 0.160834038701663 4030 24747981
SGTC_1280 0880-0253 10.1 µM -0.991523287800735 0.155832686099794 no 2889 0.160715063380393 4071 6836607
SGTC_2426 5582046 32.21 µM -0.992671184871299 0.155551073518082 no 2890 0.160435110888817 4088 2251934
SGTC_2225 6654152 15.4 µM -0.993366297388592 0.155380705474136 no 2891 0.160265739802586 3954 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1708 st033234 31.827 µM -0.995125328770672 0.15495012734555 no 2892 0.159837656554156 4188 674664
SGTC_1144 3486-0183 12.5 µM -0.995662757716128 0.15481873205719 no 2893 0.159707015518945 4075 6744069
SGTC_2627 acetyl isogambogic acid 100 µM -0.996750695124574 0.154552969067489 no 2894 0.159442767945396 4119 6857789 A caspase activator and apoptosis inducer.
SGTC_811 0416-0114 265 µM -0.997135063257411 0.154459147167667 no 2895 0.159349477780626 4146 6612453
SGTC_1991 st073000 8.92 µM -0.99847387367913 0.154132645795754 no 2896 0.159024813605271 4161 4301969 YIL048W NEO1
SGTC_2966 9084041 48.03 µM -0.998858076220837 0.154039033061024 no 2897 0.158931723819305 3984 17741380
SGTC_3012 9080433 71.4286 µM -1.00439072634343 0.152695148793111 no 2898 0.157595159103109 4088 17688859
SGTC_705 1124-0212 310 µM -1.00505445877028 0.152534451809244 no 2899 0.157435313747623 4047 9554485
SGTC_2403 6032726 181.2 µM -1.00593685476951 0.152320987768609 no 2900 0.157222973136159 4168 2881040
SGTC_3137 9097352 49.47 µM -1.00822508644675 0.151768356529564 no 2901 0.15667320861999 4121 44120435
SGTC_2192 5915882 198.485 µM -1.0104527519496 0.151231634113483 no 2902 0.156139212592286 4050 2876149
SGTC_2761 levamisole 97.89 µM -1.01078922815269 0.151150675138612 no 2903 0.156058659902501 4064 26879 An alkaline phosphatase inhibitor.
SGTC_2290 7904846 200 µM -1.01082712851526 0.151141557803127 no 2904 0.156049588239866 4140 2962154
SGTC_1487 3970-0795 2.82 µM -1.01253111505243 0.15073202373328 no 2905 0.155642088638863 4143 3765103
SGTC_237 nikkomycin 200 µM -1.0131354529485 0.150586955550402 no 2906 0.155497733095343 4116 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_38 0929-0051 58.268 µM -1.01366720692721 0.150459387692826 no 2907 0.15537078843125 4107 1379719
SGTC_1258 0671-0043 57.1 µM -1.01572071721223 0.149967426280685 no 2908 0.154881199807276 4129 4298767
SGTC_507 nimesulide 162 µM -1.01661665914533 0.149753121080234 no 2909 0.154667913021856 4169 4495 A COX2 inhibitor.
SGTC_3240 9133527 49.47 µM -1.0172664273703 0.14959782736924 no 2910 0.154513351512096 4039 17617455
SGTC_1456 k015-0012 13 µM -1.01760207851442 0.149517649315855 no 2911 0.15443354958953 4109 2989616
SGTC_2811 7967822 32.47 µM -1.01805939229429 0.149408455487057 no 2912 0.154324865922291 4163 2232244
SGTC_234 nsc-17383 10.7 µM -1.02212573560984 0.148439867043031 no 2913 0.153360697007987 4123 408974
SGTC_1433 4060-0023 7.6 µM -1.0226974445807 0.148304025476377 no 2914 0.153225460006295 4127 3840627
SGTC_2549 cedrol 20.94 µM -1.0247752452084 0.147811027768145 no 2915 0.15273462470011 4079 6708665 A sedative which affects the nervous system.
SGTC_604 1000-0114 314 µM -1.02564027124051 0.147606107773864 no 2916 0.152530588874119 4137 1572745
SGTC_375 3970-0961 9.27 µM -1.02583803260451 0.147559285913481 no 2917 0.152483967825116 4063 2898222
SGTC_2027 5150920 200 µM -1.02667356778538 0.147361574939626 no 2918 0.152287099827883 4062 786715
SGTC_1081 sertraline 6 µM -1.02726735086595 0.14722117722737 no 2919 0.152147295837364 4109 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3057 9095946 49.47 µM -1.02809758748854 0.147025021368736 no 2920 0.151951962682489 4149 24540043
SGTC_1323 1348-1351 11.2 µM -1.02929271303318 0.14674296288382 no 2921 0.15167107324492 4062 6989654
SGTC_3088 9117578 49.47 µM -1.03072052163298 0.146406465727929 no 2922 0.151335949196773 4164 678341
SGTC_1090 efavirenz 20.7 µM -1.03103219677816 0.146333080983498 no 2923 0.151262860781448 4147 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_250 brefeldin a 552.239 µM -1.03690303393421 0.144955390799079 no 2924 0.149890524927433 3995 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2318 6029776 164 µM -1.03722819636278 0.144879342045827 no 2925 0.149814760130847 4174 818325
SGTC_1529 apigenin 74 µM -1.03819382396656 0.144653660127836 no 2926 0.14958991369631 4165 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1202 1988-0068 29.6 µM -1.03938239270526 0.144376198747659 no 2927 0.149313464732083 4108 2850480
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.04157186245777 0.143866024910386 no 2928 0.148805109830847 4099 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2597 laccaic acid a 100 µM -1.04542338396168 0.142971526763535 no 2929 0.147913666898708 4149 5491415 A textile dye.
SGTC_2177 5811945 192 µM -1.04734301143415 0.142527108419256 no 2930 0.147470702676357 4189 5343475
SGTC_3246 9135460 32.98 µM -1.04777031337441 0.142428309814384 no 2931 0.147372221554804 4108 41446951
SGTC_549 1661-1316 519 µM -1.05005611780434 0.141900584466556 no 2932 0.146846156274976 4177 2857282
SGTC_415 dibenzyl ketone 100 µM -1.05031647127125 0.1418405605665 no 2933 0.146786317369878 4124 7593
SGTC_285 1486-1325 46 µM -1.05092323004331 0.141700740445673 no 2934 0.146646925143062 4189 22310230
SGTC_1540 guanosine 70.6 µM -1.05474388832691 0.14082246170499 no 2935 0.14577123676627 4018 6802 Guanosine is a purine nucleoside
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.05492158124435 0.140781704394363 no 2936 0.145730595567697 4123 442882
SGTC_1395 3486-0190 4.35 µM -1.05984952142057 0.139654574390098 no 2937 0.144606531700993 4139 6748079
SGTC_2939 9044578 71.43 µM -1.06259232176494 0.139029899819403 no 2938 0.143983435274118 4092 2653634
SGTC_1174 0739-0097 51.1 µM -1.06353311975893 0.138816071249403 no 2939 0.143770126930324 4189 728447
SGTC_2024 5144227 134 µM -1.06400615163957 0.138708643210403 no 2940 0.14366295639688 4201 3475211
SGTC_1458 k015-0034 6.33 µM -1.06484418481404 0.138518460513719 no 2941 0.143473223232196 4188 3598957
SGTC_208 k072-0098 12.366 µM -1.06508138960842 0.138464661692914 no 2942 0.143419550103617 4124 5948901
SGTC_2565 isoliquiritigenin 100 µM -1.06672966136802 0.138091221538396 no 2943 0.143046964512171 4253 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_439 amiodarone 34.4 µM -1.07049291005135 0.137241178428714 no 2944 0.142198749305167 4027 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1568 digitonin 820 nM -1.0709927808203 0.137128537025433 no 2945 0.142086337838294 4168 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1080 nisoldipine 24.4 µM -1.07115401701522 0.137092217367741 no 2946 0.142050091705535 4165 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1651 st011928 86.1 µM -1.07328330807506 0.13661319511108 no 2947 0.141572011060148 4189 720198
SGTC_948 3448-0295 75.3 µM -1.07563228380219 0.136086080076498 no 2948 0.141045871565774 4159 678569
SGTC_163 TUB2.036 7.546 µM -1.07865304168755 0.135410264410444 no 2949 0.140371213222873 4150 15992207 YJR013W GPI14
SGTC_336 4111-0029 111 µM -1.08042210443221 0.135015552545684 no 2950 0.139977128481786 4165 3131175
SGTC_1218 1348-1416 30.7 µM -1.08105593244141 0.134874325547259 no 2951 0.139836117087819 4114 6787668
SGTC_3018 9082602 49.47 µM -1.08286442645116 0.134471921455651 no 2952 0.139434301874651 4119 17332089
SGTC_861 0443-0273 110 µM -1.08679540849681 0.133600092309102 no 2953 0.1385636186982 4180 6149169
SGTC_1969 st069479 40.1 µM -1.08708886997068 0.133535163501696 no 2954 0.138498768094067 4177 3895485
SGTC_1988 st071872 53.4 µM -1.08812880628341 0.133305250700962 no 2955 0.138269124220041 4209 16414116
SGTC_2949 9072542 2.23 µM -1.08821383284969 0.133286464778174 no 2956 0.138250359719633 4240 16457352
SGTC_1807 st050092 58.9 µM -1.08888514254089 0.133138208367939 no 2957 0.138102269446119 4202 5008496
SGTC_164 4100-3994 89.624 µM -1.08932849951488 0.133040356773948 no 2958 0.13800452465688 4133 4615967
SGTC_2094 5332512 191.667 µM -1.09004037039711 0.13288334609611 no 2959 0.137847680616751 4212 755774
SGTC_1693 xanthone 101.9 µM -1.09105491094338 0.132659798977834 no 2960 0.137624360661103 4233 7020 An insecticide.
SGTC_2143 5623677 140.463 µM -1.0910810200733 0.132654049429499 no 2961 0.137618616798722 4147 5375313
SGTC_2073 5212005 126 µM -1.09185218956953 0.132484305921351 no 2962 0.137449037613753 4009 691789
SGTC_203 k066-0004 30.888 µM -1.09216319139845 0.132415893115704 no 2963 0.137380689096981 4270 6795412
SGTC_2784 7567673 72.73 µM -1.09225114652926 0.132396549552341 no 2964 0.137361363508919 4156 3471247
SGTC_2000 st075254 36.4 µM -1.09351755376308 0.132118250361456 no 2965 0.137083313051408 4093 17234175
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.09405338629147 0.132000620063785 no 2966 0.136965782324249 4121 4330530
SGTC_2248 tofa 1.1 µM -1.09456372597325 0.13188865333738 no 2967 0.1368539072984 4158 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2666 tannic acid 100 µM -1.09463968680257 0.131871993402286 no 2968 0.136837260751148 4179 16134267 A thiamine antagonist.
SGTC_3186 9110464 49.47 µM -1.09760675307363 0.131222383975487 no 2969 0.136188121380668 4196 17018021
SGTC_1030 k029-0042 36.7 µM -1.09930595338148 0.130851357980575 no 2970 0.135817318232486 4174 6080581
SGTC_1505 k297-0037 20.6 µM -1.10156412477044 0.13035940175004 no 2971 0.13532560606551 4200 4089396
SGTC_2580 diallyl disulphide 81.36 µM -1.10170160366842 0.130329492517099 no 2972 0.135295709774706 4174 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_258 haloperidol 50.781 µM -1.10266698474272 0.130119602665368 no 2973 0.135085904615868 4184 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2450 5739737 12.93 µM -1.10323111626468 0.129997059464448 no 2974 0.134963405895378 4224 2262825
SGTC_1129 3453-1384 223 µM -1.10675587655917 0.129233204063918 no 2975 0.1341997448911 4287 1084452
SGTC_1079 idarubicin 2.36 µM -1.10692573894682 0.12919647170727 no 2976 0.134163018272119 4208 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2307 7538926 6.34 µM -1.1071709978518 0.129143447794797 no 2977 0.134110002056067 4167 96582
SGTC_727 3032-0951 202 µM -1.10877239336817 0.128797603885153 no 2978 0.133764191334529 4236 3652836
SGTC_585 0kpi-0023 191 µM -1.10968228136135 0.128601387251967 no 2979 0.133567980387804 4139 64601
SGTC_2834 9001755 58.44 µM -1.11079721120917 0.1283612364636 no 2980 0.133327823574945 4124 2989575
SGTC_7 0192-1582 4.227 µM -1.11085887629553 0.128347963178557 no 2981 0.133314549539502 4241 252616
SGTC_1220 1838-0075 193 µM -1.1115767982485 0.128193502058003 no 2982 0.13316007646695 4105 5529645
SGTC_743 1275-0778 158 µM -1.11189052293793 0.128126044647391 no 2983 0.133092611974766 4190 2849257 YMR203W TOM40
SGTC_2999 9069765 71.4286 µM -1.11247734852182 0.127999930996973 no 2984 0.132966482045404 4167 2097066
SGTC_1205 4161-2785 76 µM -1.11332331934913 0.127818276714583 no 2985 0.132784797344301 4265 3498106
SGTC_3061 glucosamine 200 µM -1.11378731973352 0.127718718595931 no 2986 0.132685219058701 4131 91431 and experimental redox chemotherapeutic
SGTC_2923 7992654 58.14 µM -1.11633114188222 0.127173861916074 no 2987 0.132140208046561 4210 2985126
SGTC_52 0329-0193 875 nM -1.1170980933138 0.127009907736309 no 2988 0.131976192834325 4294 3739292
SGTC_2970 9090938 41.86 µM -1.12087166896719 0.126205358685395 no 2989 0.131171245932802 4288 17217104
SGTC_1378 2093-0007 380 nM -1.12244232970265 0.125871533552418 no 2990 0.130837207537732 4273 3618014
SGTC_1183 1254-0324 198 µM -1.12405533758332 0.125529349503342 no 2991 0.130494775404179 4296 5799357
SGTC_1810 st050138 53 µM -1.12561293011378 0.125199537892919 no 2992 0.130164696332212 4222 3444541
SGTC_2721 ifenprodil 61.44 µM -1.12629578519149 0.125055138053038 no 2993 0.130020170607646 4224 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1633 st005664 67.9 µM -1.12891418283009 0.124502517380683 no 2994 0.129467018586861 4223 2063822
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.13006426861503 0.124260328784667 no 2995 0.129224572263077 4196 6708739 YPR165W RHO1
SGTC_2753 fluvastatin 17.09 µM -1.13065984244504 0.124135040609694 no 2996 0.129099144795539 4234 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.13383060941931 0.123469508517865 no 2997 0.128432804333341 4265 5393153
SGTC_2103 5378138 10 µM -1.13895467781156 0.122399276370427 no 2998 0.127361029071654 4296 244142
SGTC_1694 st024011 44.9 µM -1.1391203894115 0.122364774241821 no 2999 0.127326472175026 4258 2787533
SGTC_2080 5212524 12.4 µM -1.1427185501833 0.121617298792647 no 3000 0.126577732688148 4170 260183
SGTC_1558 st069300 45.6 µM -1.14631081002249 0.120874256142236 no 3001 0.125833285828713 4174 24208000
SGTC_178 4092-0806 87.505 µM -1.14697872116088 0.120736454734626 no 3002 0.125695207723929 4136 2169044
SGTC_2825 7998094 58.44 µM -1.14773523053057 0.120580507612769 no 3003 0.125538941302841 4230 2987815
SGTC_3294 9122953 26.2835 µM -1.1486586854641 0.120390338568676 no 3004 0.125348374014901 4217 16459826
SGTC_878 0828-0289 13.7 µM -1.1502925599206 0.120054389051462 no 3005 0.125011697073601 4177 745350 YLR208W SEC13
SGTC_1604 st002052 72.4 µM -1.1511410987237 0.119880177433213 no 3006 0.124837096194051 4327 6254834 YHR062C RPP1
SGTC_1914 st062367 72.6 µM -1.15182098803167 0.11974071953627 no 3007 0.12469732074788 4237 978205
SGTC_72 0744-0168 198.391 µM -1.15200691940933 0.119702601493935 no 3008 0.124659114989117 4128 677577
SGTC_4 0960-0234 25.671 µM -1.15431132121041 0.119230883149782 no 3009 0.124186278348187 4249 6821112
SGTC_1055 3448-0672 86 µM -1.15574299811968 0.118938475989684 no 3010 0.123893147430991 4239 748378
SGTC_2108 5365811 200 µM -1.15697963069229 0.118686312818964 no 3011 0.123640341268029 4252 780283
SGTC_777 1315-0167 517 µM -1.15834013659952 0.118409327119017 no 3012 0.123362629105672 4271 4221767
SGTC_1751 st044839 27.194 µM -1.15951969178024 0.118169551290031 no 3013 0.123122207302345 4281 5291326
SGTC_2524 avocatin b 10.57 µM -1.16009070431508 0.118053601291964 no 3014 0.123005939219395 4231 6710748
SGTC_1084 voriconazole 435 nM -1.16080274114233 0.117909127622334 no 3015 0.122861064000915 4255 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.16631631523809 0.116794646235407 no 3016 0.12174328956645 4220 6708514
SGTC_116 0155-0182 31.788 µM -1.16665672360273 0.11672608368346 no 3017 0.121674513071876 4145 771486
SGTC_1023 4482-3888 16 µM -1.17013920489693 0.116026306782647 no 3018 0.12097247679149 4277 3303168
SGTC_2447 5741742 33.78 µM -1.17398799093523 0.115256394159845 no 3019 0.120199917914899 4305 1776504
SGTC_3112 9123419 49.47 µM -1.17430352649117 0.115193435760723 no 3020 0.120136735645788 4314 17015854
SGTC_620 0109-0052 432 µM -1.1762849398185 0.114798645726004 no 3021 0.11974051591517 4285 493037
SGTC_219 mitoxanthrone 164.414 µM -1.1763145248653 0.114792758306164 no 3022 0.119734606836094 4195 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1399 3562-5772 25 µM -1.17903254286947 0.114252789231843 no 3023 0.11919260882685 4242 23847490
SGTC_2643 anethole 100 µM -1.17979901385867 0.11410084743045 no 3024 0.11904008092589 4252 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_430 0958-0115 16.4 µM -1.18044432746264 0.113973034978556 no 3025 0.118911770272756 4216 6833180
SGTC_1169 aniline yellow 25.8 µM -1.18217718707465 0.113630325228914 no 3026 0.118567701264915 4189 6051 A DNA damaging agent.
SGTC_1734 st037168 69.4 µM -1.1836139698615 0.113346728553186 no 3027 0.118282953929791 4285 708907
SGTC_2295 7971645 200 µM -1.18451000209823 0.113170122708058 no 3028 0.118105619660655 4319 2978226 YKL099C UTP11
SGTC_195 4234-0266 16.654 µM -1.18566997345549 0.112941786802551 no 3029 0.117876328430796 4283 2303354
SGTC_2912 7964298 10.93 µM -1.19125329022515 0.111847332996093 no 3030 0.116777082441706 4282 2975850
SGTC_3228 9131799 49.47 µM -1.19531889874222 0.111055170282803 no 3031 0.115981229346863 4306 17015818
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.19533680825724 0.111051689618796 no 3032 0.115977732053778 4310 4620898
SGTC_527 4476-4215 268 µM -1.19541358859358 0.111036768461244 no 3033 0.115962739568343 4279 4418754
SGTC_2862 9027634 71.43 µM -1.19552946185229 0.111014252873394 no 3034 0.115940116222394 4235 5012562
SGTC_3342 9147791 14.508 µM -1.20209690160842 0.109743459667293 no 3035 0.114662993340318 4244 1838168
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.20325621727776 0.1095202219272 no 3036 0.114438593108147 4308 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_10 0279-0212 42.575 µM -1.20340408472269 0.109491772049042 no 3037 0.114409993987491 4271 39851 YBR002C RER2
SGTC_77 0828-0286 12.516 µM -1.2042869996202 0.109322008592103 no 3038 0.114239334844078 4189 745345
SGTC_548 1436-0017 110 µM -1.20712200963383 0.108778182383791 no 3039 0.113692579906222 4346 9677137
SGTC_458 nppb 133 µM -1.20736311601889 0.108732022029474 no 3040 0.11364616677438 4341 4549 A chloride channel blocker.
SGTC_1237 0330-0133 46.1 µM -1.21025412023823 0.108179629622046 no 3041 0.113090698391322 4227 X1237 YHR072W ERG7
SGTC_3182 9108849 49.47 µM -1.21306654038892 0.107644193724122 no 3042 0.112552190635955 4314 17133045
SGTC_1796 st049173 110.4 µM -1.21615683413886 0.107058060228682 no 3043 0.111962591833018 4262 94134
SGTC_1945 st075991 56.6 µM -1.21783247392867 0.106741207132498 no 3044 0.111643820549999 4284 1084980
SGTC_1127 asiatic acid 681.4 nM -1.22231428936888 0.105897050682002 no 3045 0.1107943988008 4237 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_311 1315-0136 58 µM -1.22312144549752 0.10574553578546 no 3046 0.110641914887173 4313 6759207
SGTC_2015 5119600 184 µM -1.22440980653116 0.105504016575109 no 3047 0.11039883588058 4336 2828786
SGTC_828 2074-0507 139 µM -1.22661777453494 0.105091033832244 no 3048 0.109983142692457 4380 X828
SGTC_2336 9001819 198.65 µM -1.22706467344473 0.105007587531513 no 3049 0.109899142071346 4365 2989602
SGTC_2645 abamectin 100 µM -1.2275455941595 0.104917842167316 no 3050 0.109808798040459 4262 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2910 7948405 25.97 µM -1.22908757018632 0.104630466096883 no 3051 0.109519487480993 4235 2971328
SGTC_81 0411-0046 9.971 µM -1.23017337761389 0.104428447955319 no 3052 0.10931609345695 4278 12925265
SGTC_2407 paclitaxel 400 µM -1.23168184728145 0.104148261358887 no 3053 0.109033976684251 4391 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3213 9129884 49.47 µM -1.23332153867136 0.103844319940971 no 3054 0.10872791255902 4293 17190742
SGTC_895 0964-0006 13.7 µM -1.23470947455932 0.103587548395755 no 3055 0.108469324232762 4313 6738897
SGTC_1497 4476-2978 41.3 µM -1.23478448737686 0.103573683975345 no 3056 0.108455361100966 4354 1528379
SGTC_2255 7941087 197.44 µM -1.23480966156685 0.103569031398281 no 3057 0.108450675384543 4425 935561
SGTC_2354 9060492 162 µM -1.2407787623969 0.102470127260872 no 3058 0.107343744405182 4343 6471895
SGTC_1950 st077106 7.18 µM -1.24264752862977 0.10212783846084 no 3059 0.106998873726846 4245 13831864
SGTC_1461 k072-0203 53.8 µM -1.24479756640271 0.101735061066725 no 3060 0.106603085465651 4227 5418714
SGTC_881 0833-0569 170 µM -1.25116022556633 0.100579150404567 no 3061 0.105438013169178 4344 5418700
SGTC_785 1270-0111 65.3 µM -1.25374122608486 0.100112999121966 no 3062 0.104968039055955 4255 6741994
SGTC_3229 9132204 49.47 µM -1.26409172728841 0.0982594528998825 no 3063 0.103098552780864 4407 17682924
SGTC_1775 st081588 35.1725 µM -1.26410352983408 0.0982573537701096 no 3064 0.10309643492265 4330 1426443 YGL099W LSG1
SGTC_115 0527-0192 112.043 µM -1.26585506296584 0.0979462006479832 no 3065 0.102782488610137 4328 4233931
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.27009930428457 0.0971952236165794 no 3066 0.10202462971576 4349 390807
SGTC_102 gallobenzophenone 83.616 µM -1.27040179033649 0.0971418634088349 no 3067 0.101970772929904 4327 70837
SGTC_1567 st069303 68.4 µM -1.27296202117199 0.0966910854132044 no 3068 0.101515759513932 4383 5581319
SGTC_3106 9121286 49.47 µM -1.2753748415303 0.0962676698606322 no 3069 0.101088299547712 4306 15943471
SGTC_271 rotenone 740 µM -1.27595051226076 0.0961668495278474 no 3070 0.100986506715456 4380 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1792 st045773 43.6 µM -1.27885178488241 0.0956599151526638 no 3071 0.100474627036211 4310 2919270
SGTC_429 1112-0049 25.5 µM -1.28335869007951 0.0948763351829028 no 3072 0.099683219791964 4342 2836170
SGTC_1094 duloxetine 25.4 µM -1.28426877385282 0.0947186816419841 no 3073 0.0995239643774702 4373 60834 A selective serotonin reuptake inhibitor.
SGTC_1402 3909-7673 35.9 µM -1.28448492356991 0.094681266480018 no 3074 0.0994861677141963 4362 5328014
SGTC_235 0330-0087 5 mM -1.28471648301569 0.0946411960061997 no 3075 0.099445688095289 4405 46494818 YHR062C RPP1
SGTC_358 0075-0058 9.45 µM -1.28567959025963 0.0944746681029967 no 3076 0.0992774535236474 4313 1069125
SGTC_1469 k284-2957 126 µM -1.28912699896509 0.0938803579886802 no 3077 0.0986769693422474 4354 23884841
SGTC_1852 st056254 31.4 µM -1.2896423742984 0.0937917483591973 no 3078 0.0985874279969863 4312 442583
SGTC_2241 6772625 37.8075 µM -1.29419621995657 0.0930114769601852 no 3079 0.0977988260705331 4167 2285411
SGTC_2532 xanthone 78.9 µM -1.29581561201436 0.0927351645376839 no 3080 0.0975195090351086 4379 7020 An insecticide.
SGTC_1249 0481-0015 10.2 µM -1.29797674470569 0.0923673626771438 no 3081 0.0971476631399379 4283 4227577
SGTC_105 0111-0055 734.78 µM -1.29989020751396 0.0920426136056613 no 3082 0.0968193009121199 4384 5179370
SGTC_1973 st070275 50.2 µM -1.30117466938662 0.0918250920298386 no 3083 0.0965993368154519 4312 17118334
SGTC_766 1391-0721 126 µM -1.30305433116101 0.0915074609612441 no 3084 0.0962781067389322 4391 1020919 YIL115C NUP159
SGTC_3049 9092223 49.47 µM -1.30343230689244 0.0914436879034816 no 3085 0.0962136064381126 4351 8623917
SGTC_2335 9018011 154.17 µM -1.30608284853605 0.0909974067838535 no 3086 0.0957621924753601 4350 6458208
SGTC_1975 st070967 30.8 µM -1.3064841560211 0.090929978283024 no 3087 0.0956939817983865 4349 261391
SGTC_407 eburnamonine 100 µM -1.31214693860832 0.08998245442131 no 3088 0.0947352805583354 4212 3195
SGTC_1408 3909-7976 48.8 µM -1.31334058479834 0.0897836674737824 no 3089 0.0945341043173777 4418 24152374
SGTC_2915 7971052 15.16 µM -1.31390271579935 0.0896901646836712 no 3090 0.0944394723370943 4291 5741558
SGTC_2985 9022375 71.43 µM -1.31456414135506 0.0895802383356092 no 3091 0.0943282140770055 4419 4939335
SGTC_1870 st057514 26.5 µM -1.31528851491985 0.0894599652502453 no 3092 0.0942064782808305 4376 5393161
SGTC_1619 st003326 88.7 µM -1.31888529794382 0.0888645431790987 no 3093 0.0936037309891514 4356 2849032
SGTC_1040 k898-0338 155 µM -1.31987279623927 0.0887015872060029 no 3094 0.0934387457958036 4374 20969351
SGTC_2603 homopterocarpin 100 µM -1.32032130175788 0.0886276488127888 no 3095 0.0933638832020721 4367 101795 A weak amylase inhibitor.
SGTC_2128 5255449 168.493 µM -1.32077115556994 0.0885535342702456 no 3096 0.0932888400754466 4324 736008
SGTC_2493 resveratrol 26.09 µM -1.32988565086098 0.0870618267541309 no 3097 0.091777974927398 4307 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1552 6-methylflavone 10.6 µM -1.33395308864641 0.0864022257833509 no 3098 0.0911096156027739 4340 689013
SGTC_1880 MG-132 525 µM -1.33493629493166 0.0862433451842565 no 3099 0.0909485987344977 4345 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2113 5491891 107.031 µM -1.3366493374162 0.0859670493497492 no 3100 0.0906685631624588 4389 789979
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.33702819018476 0.085906033900994 no 3101 0.0906067176100176 4418 23847180
SGTC_2288 7946289 167.31 µM -1.33893157054319 0.0855999787742557 no 3102 0.0902964754275241 4420 1246052
SGTC_1819 st053448 58.6 µM -1.34789522325754 0.0841696319181327 no 3103 0.0888460423349264 4313 2857616
SGTC_3318 9139014 38.6185 µM -1.3493434459737 0.0839402296578451 no 3104 0.0886133384293012 4390 16643984
SGTC_1370 2001-0092 44.6 µM -1.35079836855772 0.0837102392124008 no 3105 0.0883800154237738 4405 790957
SGTC_819 1013-0258 27.7 µM -1.35157284265014 0.0835880055555014 no 3106 0.0882560014283438 4402 5753198
SGTC_1154 4088-0362 150 µM -1.35167533660268 0.0835718391991407 no 3107 0.0882395991307109 4407 6618304
SGTC_2275 7947463 200 µM -1.35177894767469 0.0835554990277733 no 3108 0.0882230203678493 4349 1225414
SGTC_1406 3909-7906 11.9 µM -1.35967871579501 0.0823167092655076 no 3109 0.0869658081799273 4437 X1406
SGTC_2201 6605497 169.863 µM -1.36407601563923 0.0816331725369072 no 3110 0.0862718212443233 4346 670741
SGTC_1102 cgs 12066b 26.1 µM -1.36757586130684 0.0810922055738649 no 3111 0.085722438253877 4431 6438352 A 5-HT1B full agonist.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.36872153967858 0.0809157084730444 no 3112 0.0855431673150666 4391 16623 A steroid.
SGTC_452 diindolylmethane 8 µM -1.37282751670057 0.0802855451455042 no 3113 0.0849029871260497 4416 3071 Inhibits expression of several cancer promoting factors.
SGTC_2742 clothiapine 36.27 µM -1.37450396967675 0.0800293210668256 no 3114 0.0846426393596459 4448 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1779 st039427 55 µM -1.37460942947376 0.0800132235983236 no 3115 0.0846262818316994 4407 1124498
SGTC_1321 1326-2144 215 µM -1.37483450456474 0.0799788761429191 no 3116 0.0845913790926265 4389 3513030
SGTC_3231 9132313 49.47 µM -1.37578200780895 0.0798344051969361 no 3117 0.0844445667102412 4367 4905967
SGTC_497 capsazepine 133 µM -1.3761031524567 0.0797854833468691 no 3118 0.0843948498499726 4373 2733484 A calcium channel blocker.
SGTC_251 melphalan 456.522 µM -1.37644036342912 0.0797341384280941 no 3119 0.0843426693813495 4461 460612 A DNA alkylator.
SGTC_13 0199-0087 65 µM -1.37655285895566 0.0797170150280857 no 3120 0.0843252670625133 4514 4589825
SGTC_2873 9040596 71.43 µM -1.37706359127363 0.0796393093742785 no 3121 0.084246294013265 4390 6463863
SGTC_694 1315-0438 43.2 µM -1.37808507305931 0.0794840674010858 no 3122 0.0840885118183752 4433 6793154
SGTC_807 1315-0151 48 µM -1.38280206832877 0.0787701607861698 no 3123 0.0833627823147469 4442 4011080
SGTC_2005 4024620 188 µM -1.3894351542711 0.0777744920839501 no 3124 0.0823502333280554 4386 236743
SGTC_655 k060-0012 42 µM -1.38989500707313 0.0777058209384713 no 3125 0.0822803810010508 4409 5994525
SGTC_1645 Cervolide 78 µM -1.39032766135655 0.0776412534602426 no 3126 0.0822147009198963 4438 23173 A fragrance.
SGTC_2138 5575593 77.673 µM -1.39328925832047 0.0772003705907696 no 3127 0.0817661687837141 4440 762213
SGTC_588 3970-1144 52.9 µM -1.39636300358984 0.0767448068375048 no 3128 0.0813026050292153 4320 1888707
SGTC_308 4092-1169 104 µM -1.39978799554682 0.0762395954540036 no 3129 0.0807884068342211 4403 2268590 YDL196W YDL196W
SGTC_692 k241-0027 77.8 µM -1.40415437013948 0.0755991984505657 no 3130 0.0801364430816684 4463 3600480
SGTC_351 caspofungin 25 nM -1.4054822732678 0.0754052557240416 no 3131 0.0799389584707987 4430 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_292 k038-0015 474 µM -1.4118676063947 0.0744779582076742 no 3132 0.0789944737247751 4432 46368540
SGTC_2594 a-mangostin 100 µM -1.41292865801743 0.0743247161578423 no 3133 0.0788383508956309 4439 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3117 9124945 49.47 µM -1.41476303525952 0.0740603548888119 no 3134 0.0785689927492913 4349 17592065
SGTC_2001 4023502 57.655 µM -1.41639454441174 0.0738258340613068 no 3135 0.0783300101725216 4453 108941 YCR052W RSC6
SGTC_2888 9058547 12.99 µM -1.41673295406832 0.0737772606096363 no 3136 0.0782805092054054 4371 16476514
SGTC_2268 7933382 153.85 µM -1.42859776714934 0.0720896485727781 no 3137 0.0765599381498772 4492 935025 YOR257W CDC31
SGTC_326 k292-0812 17.5 µM -1.42865136050782 0.0720820933393921 no 3138 0.0765522321244473 4430 3579357
SGTC_536 3852-0578 10.6 µM -1.43006644348178 0.0718828239355061 no 3139 0.0763489750477205 4486 2869208
SGTC_2807 7945238 51.95 µM -1.43249503296354 0.0715418194081469 no 3140 0.0760010993044999 4429 17148797
SGTC_930 2810-3379 265 µM -1.43505640895998 0.0711835163722473 no 3141 0.0756355119545975 4463 1015764
SGTC_2916 7875993 68.79 µM -1.43544383616619 0.0711294405419726 no 3142 0.0755803309931507 4347 1299250
SGTC_2193 5925765 200 µM -1.43790853065147 0.0707861648649574 no 3143 0.0752300044689507 4463 877370
SGTC_1415 3966-0071 78.1 µM -1.4419209346834 0.0702300533035815 no 3144 0.0746623398311136 4366 2893185
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.44945756161043 0.0691945820336586 no 3145 0.073604921849483 4462 688669
SGTC_2176 5809774 33.9695 µM -1.44949690631709 0.0691892074242717 no 3146 0.0735994318355834 4380 2870539
SGTC_3029 9088683 49.47 µM -1.45120989800781 0.0689555191492562 no 3147 0.0733607107764476 4469 25236615
SGTC_779 1360-0071 233 µM -1.45284138253255 0.0687335162813341 no 3148 0.0731338995680426 4494 7566
SGTC_2890 9046729 58.44 µM -1.45546665082449 0.068377442630231 no 3149 0.0727700581125174 4438 903329
SGTC_2129 girgensonine 121.053 µM -1.45611025942584 0.0682903655270778 no 3150 0.0726810709380234 4465 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_896 0964-0007 44.5 µM -1.45707960692134 0.0681593790748439 no 3151 0.0725472034693029 4421 6756758
SGTC_941 3237-0776 460 µM -1.45974351916122 0.0678004074189288 no 3152 0.0721802882744909 4491 760008
SGTC_1931 st074438 57.1 µM -1.46210440126298 0.06748349224158 no 3153 0.0718563014267491 4473 2787313
SGTC_1354 1498-1681 81 µM -1.46395653817348 0.0672356712386199 no 3154 0.0716029119115936 4477 5754243
SGTC_3315 9136395 68.55 µM -1.47615680648218 0.0656207872489984 no 3155 0.0699509009644802 4467 16876844
SGTC_3103 9120822 49.47 µM -1.47761506875796 0.0654297942330381 no 3156 0.0697554193524592 4489 17141819
SGTC_1856 st057054 55.7 µM -1.47787689993035 0.0653955471158847 no 3157 0.0697203651751102 4462 1266018
SGTC_1356 1502-0781 85.8 µM -1.48169228378682 0.0648980767884949 no 3158 0.0692110955836177 4493 567702
SGTC_1390 3413-2614 145 µM -1.48597225113824 0.0643435333039334 no 3159 0.0686432304524299 4478 3421432
SGTC_1686 st019653 115.5 µM -1.48753603674072 0.0641418389189369 no 3160 0.0684366463765283 4488 97252
SGTC_64 000l-0018 272.079 µM -1.49012885019796 0.0638085057310975 no 3161 0.0680951798595569 4406 6811119
SGTC_1139 k015-0024 46.9 µM -1.49242337763798 0.0635146455290355 no 3162 0.0677940951343853 4514 2766652
SGTC_3206 9114350 49.47 µM -1.4938133755829 0.0633371413723441 no 3163 0.067612202267525 4349 17087243
SGTC_2816 7982706 58.44 µM -1.50035078225991 0.0625074823618599 no 3164 0.0667617807454677 4483 2981853
SGTC_3159 9100096 49.47 µM -1.50121972712004 0.0623978458913147 no 3165 0.0666493696117461 4436 25236875
SGTC_2768 sulfasalazine 50.2 µM -1.50224189252439 0.0622690692933197 no 3166 0.0665173246597154 4473 5384001 An antioxidant and salicylic acid derivative.
SGTC_1279 0874-0590 65.2 µM -1.50439906442351 0.061997980322525 no 3167 0.0662393225180703 4562 3523074
SGTC_2309 7664088 163.95 µM -1.50494659939063 0.0619293190734936 no 3168 0.0661689031990386 4471 704922
SGTC_673 1082-0474 110 µM -1.50559409104358 0.0618481997893441 no 3169 0.0660857031460165 4486 3098046
SGTC_2544 sphondin 68.51 µM -1.50618128055799 0.0617747070316417 no 3170 0.0660103217698484 4455 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2697 mebhydrolin 72.4 µM -1.50799951737715 0.0615475684789073 no 3171 0.0657773252688198 4526 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_775 4577-0580 57.3 µM -1.52101486152988 0.0599406545046989 no 3172 0.0641280539496211 4525 2006902
SGTC_468 gf-109203x 121 µM -1.52337950305243 0.0596522677434101 no 3173 0.0638318935032238 4585 2396 A protein kinase C inhibitor.
SGTC_2139 5578692 56.4705 µM -1.52769565182913 0.0591286838243197 no 3174 0.0632940601048813 4485 650991 YMR113W FOL3
SGTC_2880 9042983 58.44 µM -1.53025746164541 0.0588196242803302 no 3175 0.0629765065679837 4466 6464714
SGTC_2278 7948257 134.34 µM -1.53179997374083 0.0586341462819328 no 3176 0.0627859012808929 4514 1247028
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.53794033668362 0.0579003519503263 no 3177 0.0620316017607392 4522 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1022 4477-0945 21.3 µM -1.53869597054694 0.0578105521474423 no 3178 0.0619392682554805 4460 4648966
SGTC_3217 9129673 49.47 µM -1.53899169098318 0.0577754384483012 no 3179 0.0619031623716198 4491 17248312
SGTC_45 0kpi-0036 14.9 µM -1.54445850152357 0.0571293277436959 no 3180 0.0612386485430993 4487 2795021
SGTC_1519 esterone 74 µM -1.54645655526885 0.056894606257122 no 3181 0.0609971723062529 4506 698 A steroid.
SGTC_1506 4226-2149 212 µM -1.55349532675204 0.0560737714970112 no 3182 0.060152422427795 4525 991114
SGTC_373 0844-0104 25.9 µM -1.55590880021265 0.0557944814458361 no 3183 0.0598648902385838 4537 5375804
SGTC_2803 7707263 71.43 µM -1.55637332820564 0.0557408518833188 no 3184 0.0598096718626663 4489 2199229
SGTC_1662 st014054 52 µM -1.55655025016145 0.0557204370174101 no 3185 0.0597886516701163 4604 2838777
SGTC_230 MPP+ 141.667 µM -1.55817623518037 0.0555330922485039 no 3186 0.059595738427906 4493 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2130 NSC 7 2.4545 µM -1.55820325341655 0.0555299834328094 no 3187 0.0595925370033665 4568 21448
SGTC_1864 st057645 30.4 µM -1.56036067827821 0.0552821855248759 no 3188 0.059337335813064 4562 688666
SGTC_2416 tofa 880 nM -1.5611484541459 0.0551919209842918 no 3189 0.0592443638743387 4475 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3127 9126946 49.47 µM -1.56224279302836 0.0550667232303992 no 3190 0.059115401508021 4472 27243249
SGTC_2342 7990637 118.86 µM -1.56490526901883 0.0547630598775286 no 3191 0.058802561529024 4504 2033102 YER133W GLC7
SGTC_3244 9134489 49.47 µM -1.56752594340298 0.0544654583747451 no 3192 0.0584959035099834 4529 16584271
SGTC_1289 0976-0073 69.1 µM -1.57407428948008 0.0537274243461881 no 3193 0.057735137848747 4582 3391136
SGTC_2430 5571206 200 µM -1.58152290898062 0.0528975777894809 no 3194 0.0568792625449431 4513 1731771
SGTC_2066 5222451 176 µM -1.58430394484 0.0525903632301413 no 3195 0.0565622842687992 4482 2281147
SGTC_1998 st075797 76.8 µM -1.58567528148033 0.052439397020673 no 3196 0.0564064946123303 4525 24208315
SGTC_264 promethazine 12.5 mM -1.58583949633477 0.0524213422036723 no 3197 0.0563878618046876 4399 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_593 1203-0218 61.7 µM -1.59187535518881 0.0517611394072212 no 3198 0.055706357030312 4584 3666956
SGTC_2826 7992541 19.48 µM -1.59817907450854 0.0510787110119147 no 3199 0.0550015646793989 4536 2985066
SGTC_2667 digitoxin 100 µM -1.59868563053414 0.0510241845314877 no 3200 0.0549452360218104 4512 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2016 5121758 140 µM -1.60098859176273 0.0507768740423194 no 3201 0.0546897229717708 4471 2795203
SGTC_49 0717-0965 32.132 µM -1.60560252258217 0.0502842653750888 no 3202 0.0541806354332817 4599 5889349 YGL099W LSG1
SGTC_1523 st012844 44.7 µM -1.60711929040375 0.0501231613152993 no 3203 0.0540141012066028 4582 4274103
SGTC_2652 actinonin 100 µM -1.61396807236176 0.0494008330431468 no 3204 0.0532671758872109 4598 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_284 0988-0104 32.6 µM -1.61539882719664 0.0492509884333903 no 3205 0.0531121770332739 4533 4666532
SGTC_2952 9073731 13.78 µM -1.61879664454049 0.048896585392684 no 3206 0.0527455121718262 4536 16457353
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.61969091666964 0.0488036495287681 no 3207 0.0526493441937328 4561 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2518 prenyletin 46.28 µM -1.62098697707983 0.0486692090461191 no 3208 0.0525102158396368 4585 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1005 4092-0690 4.4 µM -1.63370261494948 0.0473658589692321 no 3209 0.0511606545180833 4566 1529343
SGTC_1522 st012842 45.6 µM -1.635146854773 0.0472196103099005 no 3210 0.0510091329628617 4406 3491067 YOR116C RPO31
SGTC_80 0159-0065 512.242 µM -1.63615766032474 0.0471174681624605 no 3211 0.0509032975422032 4528 1548079
SGTC_1329 1447-1697 50.6 µM -1.63627442641244 0.0471056803423248 no 3212 0.0508910829333709 4552 2840515
SGTC_1832 st054113 55 µM -1.64465251057739 0.0462660447335304 no 3213 0.0500207456971133 4584 1251267
SGTC_1767 st044992 70.3 µM -1.64856815971583 0.0458777680386655 no 3214 0.0496180681280801 4593 9600693
SGTC_1011 4112-3381 17.4 µM -1.65500025014038 0.0452456477424408 no 3215 0.0489622235837814 4598 2877139
SGTC_2030 5175110 200 µM -1.65683484565372 0.0450666409988588 no 3216 0.0487764349674916 4570 2831986
SGTC_2792 7535235 81.82 µM -1.66058211877954 0.0447027799437338 no 3217 0.0483987013373776 4539 1281891
SGTC_2101 5377231 179.231 µM -1.66074337269791 0.0446871754040298 no 3218 0.048382499229551 4590 2844213
SGTC_2710 st078562 53.7235 µM -1.6645158362049 0.044323364333023 no 3219 0.0480046945167283 4548 17250908
SGTC_1900 st060200 72.8 µM -1.6648675128098 0.0442895711226035 no 3220 0.0479695954581997 4553 688945
SGTC_2144 5628481 200 µM -1.66549000377091 0.0442298058058383 no 3221 0.0479075181537207 4564 2818399
SGTC_1961 st076550 68.7 µM -1.66619940884973 0.0441617751447768 no 3222 0.0478368518455541 4572 1579337
SGTC_25 0118-0223 35.662 µM -1.66657511327694 0.0441257799538974 no 3223 0.0477994604369441 4553 5333628
SGTC_2019 4016004 108 µM -1.66703041444023 0.0440821905275786 no 3224 0.0477541786520254 4582 45595336
SGTC_1176 0848-0131 83.3 µM -1.66758065317473 0.0440295583484404 no 3225 0.0476995007378843 4622 6769040
SGTC_1171 0368-0077 21.4 µM -1.6678285641805 0.0440058613940873 no 3226 0.0476748818985972 4549 3239779
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.66903774865439 0.0438904270183265 no 3227 0.047554949480743 4604 688788
SGTC_2398 5228213 48.84 µM -1.67261566126376 0.0435502927825148 no 3228 0.0472014908952778 4528 80771 YMR134W ERG29
SGTC_1691 st019933 84.6 µM -1.67287547055157 0.0435256770958925 no 3229 0.0471759068107202 4579 6176082
SGTC_331 k048-0133 24.5 µM -1.67476319536279 0.043347161255798 no 3230 0.0469903513654119 4584 6813582
SGTC_1358 1509-0022 2.48 µM -1.67498262062626 0.0433264493467128 no 3231 0.0469688208009032 4597 3258434
SGTC_1168 k815-0004 80.5 µM -1.68427386600468 0.0424567413662556 no 3232 0.0460643768118753 4585 642433
SGTC_2205 7238770 200 µM -1.69441794755664 0.0415233837811388 no 3233 0.0450929457214775 4617 279867
SGTC_1278 0874-0585 172 µM -1.69658218815772 0.0413264195709893 no 3234 0.0448878398258297 4608 766306
SGTC_3094 9117742 49.47 µM -1.69911547928454 0.041096831361443 no 3235 0.0446487136808052 4550 17149698
SGTC_2043 5101342 149 µM -1.70140594721446 0.0408901411917664 no 3236 0.044433392657643 4611 678451
SGTC_2932 9016711 44.54 µM -1.70210364735871 0.0408273490612018 no 3237 0.0443679701581723 4566 7117328
SGTC_2646 retinol 96.75 µM -1.70230958314727 0.0408088300615689 no 3238 0.0443486746524665 4612 445354 A vitamin A analog and teratogen.
SGTC_1466 k213-0079 57.5 µM -1.70988881277542 0.0401319873181045 no 3239 0.0436432177757975 4586 3657981
SGTC_2188 6126565 140.678 µM -1.71179863659823 0.0399628820218105 no 3240 0.0434668917127607 4507 874518
SGTC_1791 st048313 56.1 µM -1.71732167705513 0.0394771012410603 no 3241 0.0429602067366808 4607 1204976
SGTC_3060 1327-0027 12.5 µM -1.71744153039635 0.0394666129912952 no 3242 0.0429492644967777 4522 16000455 YPR107C YTH1
SGTC_2204 7233102 200 µM -1.72535212086531 0.0387793614056162 no 3243 0.0422320171351725 4598 2172480
SGTC_3270 9137563 49.47 µM -1.7267167136955 0.038661800815826 no 3244 0.0421092762405421 4597 17015724
SGTC_1907 st060210 83.7 µM -1.72882421725804 0.0384808086390441 no 3245 0.0419202802456504 4593 688793
SGTC_2340 7987427 183.45 µM -1.73425015370182 0.0380180059818468 no 3246 0.0414368537946018 4587 2239331
SGTC_1259 0671-0132 43 µM -1.73575211268005 0.0378907026266203 no 3247 0.0413038373571855 4538 X1259
SGTC_3187 9109394 49.47 µM -1.73755657409421 0.0377382199104398 no 3248 0.041144488634216 4601 17098090
SGTC_2770 toltrazuril 17.5 µM -1.73961882387947 0.0375645669634681 no 3249 0.0409629858440693 4536 68591 Kills coccidiodes.
SGTC_1680 diphenhydramine 100 µM -1.74165245977037 0.0373939629519213 no 3250 0.0407846379423085 4548 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2263 7948595 193.29 µM -1.75580794135066 0.0362239036143081 no 3251 0.0395606039782556 4629 2971371
SGTC_1343 1487-0095 224 µM -1.76771286582753 0.0352632294482614 no 3252 0.0385544590084176 4601 4560101 YGL055W OLE1
SGTC_1468 k284-1086 134 µM -1.77008570930717 0.035074271708403 no 3253 0.0383564319030969 4613 15996457
SGTC_1207 2099-0101 141 µM -1.77804627257253 0.0344464052557795 no 3254 0.03769812772265 4612 5837381
SGTC_2921 7974240 10.71 µM -1.77931443079374 0.0343472409127655 no 3255 0.0375941131904154 4652 2979074 YDR527W RBA50
SGTC_3356 9151811 4.48 µM -1.7900815772179 0.0335147155016623 no 3256 0.0367203989917893 4645 1859254 YPR165W RHO1
SGTC_1860 st056228 74.6 µM -1.80089547691138 0.0326953667042005 no 3257 0.0358596780254733 4619 688679
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.8062586380866 0.0322951786892108 no 3258 0.0354389746906636 4643 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_446 go6976 132 µM -1.81006335087228 0.032013736922391 no 3259 0.0351429817725616 4629 3501 A protein kinase C inhibitor.
SGTC_2924 9010168 62.78 µM -1.81513460221407 0.0316417587205039 no 3260 0.0347516133904812 4609 2993929
SGTC_2361 9034121 116 µM -1.82036460839804 0.0312618843416292 no 3261 0.0343517491788369 4650 6496917
SGTC_3216 9129716 49.47 µM -1.82174756946473 0.0311620678166461 no 3262 0.0342466482419821 4546 8056934
SGTC_1511 0906-3109 28.5 µM -1.82527751364615 0.0309084855193155 no 3263 0.033979580853846 4636 2882180
SGTC_2097 5376186 200 µM -1.82786940075144 0.0307233802891279 no 3264 0.0337845771943635 4623 742755
SGTC_1015 4130-4525 82 µM -1.83733240297438 0.0300553361772799 no 3265 0.0330804195870579 4627 1363237
SGTC_3282 9108498 15.4605 µM -1.84230671751999 0.0297090302575891 no 3266 0.0327151488664952 4618 16459645
SGTC_2716 st080858 38.6235 µM -1.84952206754944 0.0292125959859876 no 3267 0.032191232167222 4619 5296050
SGTC_964 1287-0107 19.4 µM -1.85236525549982 0.0290188792802889 no 3268 0.0319866954953025 4628 51516812 YPR165W RHO1
SGTC_2376 9072922 81.32 µM -1.86067820813483 0.0284586021911412 no 3269 0.0313948165219252 4630 17087968
SGTC_1141 3253-0389 52.6 µM -1.86175230397752 0.0283868711400291 no 3270 0.0313190061602662 4640 5402031
SGTC_2884 9058502 51.95 µM -1.86184169859035 0.0283809079117009 no 3271 0.0313127034619127 4633 6471554
SGTC_2927 9011802 47.9 µM -1.87896755815133 0.0272575716719113 no 3272 0.0301244615407307 4612 43912568
SGTC_889 0919-1524 82.7 µM -1.88877601425764 0.0266310795083756 no 3273 0.0294609240268014 4676 3905452
SGTC_143 4032-1194 15.74 µM -1.89330393268703 0.026345953122511 no 3274 0.0291587312396527 4663 1806963
SGTC_700 3453-2283 142 µM -1.89866688479809 0.0260115493761845 no 3275 0.0288041441053621 4688 565664
SGTC_1012 4112-3522 18 µM -1.89985661354108 0.0259378477033753 no 3276 0.0287259695170035 4655 3112398
SGTC_1117 retinoic acid 1.10837 µM -1.90003092217593 0.0259270642673374 no 3277 0.0287145308918365 4695 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1357 1503-1303 39.5 µM -1.90970584071337 0.0253343894445085 no 3278 0.028085549268213 4635 292895
SGTC_540 1187-0821 17.3 µM -1.91131372632938 0.0252370005109203 no 3279 0.0279821380707714 4607 847520
SGTC_1859 st055998 20 µM -1.91347214312513 0.0251067595200247 no 3280 0.0278438182035818 4603 676301
SGTC_1954 st077032 68.9 µM -1.91792132919881 0.0248400682582011 no 3281 0.0275604936338169 4604 698907
SGTC_1702 st027038 51 µM -1.92582962974902 0.024371896892341 no 3282 0.0270628252316734 4700 5521182
SGTC_2161 5662504 8.5105 µM -1.95830522902119 0.0225262999981524 no 3283 0.0250971037991994 4682 2859334
SGTC_1501 4491-0275 38.4 µM -1.96042917007083 0.0224098160666263 no 3284 0.0249728245905916 4694 5104718
SGTC_2195 6536160 144.242 µM -1.9814369644728 0.0212847982557939 no 3285 0.0237711459321034 4696 3834386
SGTC_385 1494-0393 12.4 µM -1.98331400077349 0.0211866446501213 no 3286 0.0236661832376625 4649 3090647
SGTC_1621 st003705 32.4 µM -1.99141377507971 0.0207674724247591 no 3287 0.0232177080329101 4691 24207032
SGTC_659 k018-0002 107 µM -2.00043881302368 0.0203087092217548 no 3288 0.0227264504029626 4664 6797879 YHR007C ERG11
SGTC_1681 tripelennamine 100 µM -2.00082158744228 0.0202894433530887 no 3289 0.0227058100773487 4622 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1446 4239-0190 62 µM -2.00508732044225 0.0200757861625432 no 3290 0.0224768563802128 4688 1340085
SGTC_2397 5161689 200 µM -2.01097102791167 0.0197842233379027 no 3291 0.0221642585044791 4665 2259942
SGTC_1133 3473-0247 50 µM -2.03742816600265 0.0185171846260339 no 3292 0.0208035768534875 4659 711311
SGTC_1034 k072-0165 12.7 µM -2.04027964656447 0.0183848451172536 no 3293 0.0206612404144168 4688 5835461
SGTC_652 0437-0092 114 µM -2.04156299877374 0.0183255471026844 no 3294 0.0205974493829158 4672 3091274
SGTC_567 1080-0542 68.4 µM -2.04212962778877 0.0182994175858932 no 3295 0.0205693373382368 4613 5950415
SGTC_465 cgp-37157 41 µM -2.06079559128156 0.0174562289183685 no 3296 0.0196612726344735 4749 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1794 st048918 76.9 µM -2.06544063337765 0.0172516312210022 no 3297 0.0194406636274683 4692 672303
SGTC_2346 9031566 143.75 µM -2.07847889335453 0.0166882547020236 no 3298 0.0188326364685781 4691 4771086
SGTC_202 3594-0513 34.79 µM -2.08491070289009 0.0164161866359831 no 3299 0.0185387034848923 4756 708429
SGTC_85 0868-0259 160.055 µM -2.09675938008372 0.0159249179168748 no 3300 0.0180074405250854 4683 83173
SGTC_2117 5521686 200 µM -2.10029603719919 0.0157807462014479 no 3301 0.0178514038289708 4701 803312
SGTC_2444 5485484 36.41 µM -2.10797726320235 0.0154714730408418 no 3302 0.0175164780940423 4723 6790631
SGTC_3320 9137005 35.139 µM -2.12485688590968 0.0148100734741686 no 3303 0.0167992782172943 4716 4908713
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.13381648376748 0.0144689914629149 no 3304 0.0164289030151456 4703 229346 A bile salt which induces apoptosis.
SGTC_953 1188-0045 9.7 µM -2.13422757367906 0.0144535053172199 no 3305 0.0164120783085663 4678 6144426
SGTC_2649 anisomycin 9.56 µM -2.13444117141126 0.0144454645232276 no 3306 0.0164033422042785 4740 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2691 st077356 60.2 µM -2.14744115220405 0.0139632814521511 no 3307 0.0158790887121885 4681 2839272
SGTC_1126 isoteolin 1.0172 µM -2.15922663203151 0.0135382013429347 no 3308 0.0154162944401044 4676 133323
SGTC_1760 st045453 10.4495 µM -2.16134739631865 0.0134629070863434 no 3309 0.0153342571437325 4712 3323419 YIL048W NEO1
SGTC_335 4077-0256 27.6 µM -2.16576662915854 0.0133071703603491 no 3310 0.0151645123012746 4620 3121989
SGTC_595 3909-8003 73.7 µM -2.19042410715119 0.0124664848058511 no 3311 0.0142467466329293 4756 699517
SGTC_2950 9072895 21.46 µM -2.19278801885529 0.0123883583388992 no 3312 0.0141613277820927 4666 17332245
SGTC_945 3381-0768 11.3 µM -2.19424754002017 0.0123403337092808 no 3313 0.0141088092881895 4709 1126236 YIL048W NEO1
SGTC_1752 st044819 83.042 µM -2.19840222386974 0.0122045084007618 no 3314 0.013960227682776 4677 441209 YML126C ERG13
SGTC_245 methotrexate 289.6 µM -2.20900576175675 0.0118637147055375 no 3315 0.0135871200730348 4689 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3338 9144300 39.5675 µM -2.25313075296448 0.010532711614817 no 3316 0.0121254529743921 4728 4901274
SGTC_816 0325-0417 81.3 µM -2.263150775364 0.0102492600624346 no 3317 0.0118131982216533 4738 68101
SGTC_196 k015-0023 18.111 µM -2.26999587746675 0.0100594680530402 no 3318 0.0116039165876119 4716 5211998
SGTC_1839 st053978 48 µM -2.28319432198844 0.00970216197427894 no 3319 0.0112094622187867 4757 3788398
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.2832371744238 0.00970102017817106 no 3320 0.0112082007372304 4748 368090
SGTC_2127 5253358 187.912 µM -2.30809369714107 0.00905818972403104 no 3321 0.0104969628379229 4705 20612
SGTC_826 1683-5028 118 µM -2.32381378205672 0.00867117669115372 no 3322 0.010067738376293 4761 722377
SGTC_3001 9076041 71.4286 µM -2.32873364492721 0.00855307127498836 no 3323 0.00993659028425995 4731 16004211
SGTC_813 k007-0158 173 µM -2.33163402877396 0.00848410841110665 no 3324 0.00985997603884987 4728 6523916
SGTC_1066 ketoconazole 628 nM -2.3317551594261 0.00848123891501139 no 3325 0.0098567876001467 4756 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2327 6189656 200 µM -2.35462009554244 0.00795460846382328 no 3326 0.00927082556851111 4751 5349088
SGTC_2705 st078069 42.8 µM -2.36245473733599 0.00778089202570498 no 3327 0.00907717909430437 4743 1530061
SGTC_2277 7947813 106.88 µM -2.37223053617356 0.00756882196031584 no 3328 0.00884052742155259 4740 1246798
SGTC_2219 9098279 200 µM -2.38114185995441 0.00737995737585754 no 3329 0.00862953203088341 4745 902349
SGTC_561 1550-0330 72.9 µM -2.38339549121232 0.00733285744037465 no 3330 0.00857687717196328 4736 6812934
SGTC_535 2293-4129 48.2 µM -2.41450043885492 0.00670932830551819 no 3331 0.00787840199465419 4741 396118 YIL048W NEO1
SGTC_313 3474-0040 5.03 µM -2.43313419317287 0.00635866373466078 no 3332 0.00748437604709254 4760 1043375 YIL048W NEO1
SGTC_1518 st038567 90.8 µM -2.44806906037764 0.00608942080448677 no 3333 0.00718120619408677 4729 77966
SGTC_2445 5742597 35.57 µM -2.47257134994207 0.00566953714467198 no 3334 0.00670724665717104 4749 1774255
SGTC_1515 3460-0031 42.1 µM -2.48558786827538 0.00545710420958919 no 3335 0.00646688266454994 4747 2876596
SGTC_2804 7954240 19.48 µM -2.50761945179894 0.00511362368763168 no 3336 0.00607737455028142 4732 828705
SGTC_530 4358-1714 28 µM -2.52176284815658 0.00490339657482414 no 3337 0.00583842005117468 4755 1564641
SGTC_2502 avocadyne acetate 18.59 µM -2.54296729953923 0.00460263211182801 no 3338 0.00549577576388 4747 3952079
SGTC_1835 st008666 49.2 µM -2.54513139617024 0.00457288211383925 no 3339 0.00546183124869373 4750 690455
SGTC_1029 k015-0030 64.7 µM -2.58207273378074 0.00409084906955855 no 3340 0.00491044423591732 4767 2208316
SGTC_2837 9008476 45.46 µM -2.61003393276726 0.00375678324440645 no 3341 0.00452666209672735 4744 2992805
SGTC_227 fluconazole 33.516 µM -2.74314471279607 0.00247843633384759 no 3342 0.00304269304098739 4785 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3218 9131285 49.47 µM -2.77042708942715 0.00227107329620766 no 3343 0.00279914161575314 4752 17156417
SGTC_1797 st048695 56.8 µM -2.77586181060327 0.00223169324179008 no 3344 0.00275278017355036 4770 592262 YIL048W NEO1
SGTC_84 0443-0269 128.823 µM -2.78844351115573 0.00214288988022931 no 3345 0.00264809914428319 4776 6150058
SGTC_1826 st055655 41.6 µM -2.79173730337289 0.00212017728278697 no 3346 0.00262129498365086 4775 676168
SGTC_154 3389-1638 511.116 µM -2.80899560577976 0.00200470150765307 no 3347 0.00248481624494531 4775 5238686
SGTC_2489 cantharidin 73.42 µM -2.84499307786445 0.00178201653376439 no 3348 0.0022206194099951 4772 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1731 st035964 63 µM -2.91876780450971 0.00139440651386387 no 3349 0.00175708938062375 4745 6739575
SGTC_1728 st035614 33.7865 µM -2.92194379360325 0.0013795953416042 no 3350 0.00173927154382849 4760 15945546
SGTC_2221 6807166 181.081 µM -2.92643802083131 0.001358882079065 no 3351 0.00171433908294011 4803 674925
SGTC_2766 oltipraz 83.91 µM -3.0463152634611 0.000901078800108437 yes 3352 0.00115832394741786 4792 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_50 0929-0078 56.389 µM -3.26798908993372 0.000406118146172949 yes 3353 0.000541572704343027 4770 1377751
SGTC_1463 k081-0032 34.1 µM -3.66643994800868 8.57712655071976e-05 yes 3354 0.000122975321553061 4542 977755
SGTC_2056 5235370 200 µM -3.84767502542221 4.01245288185894e-05 yes 3355 5.96220416495171e-05 4788 5511916
SGTC_2496 diffractaic acid 79.83 µM -4.54342593257941 1.59754163847749e-06 yes 3356 2.76736291581315e-06 4800 94870 An apoptosis inducer which activates caspases.