SGTCid condition conc unit AUA1|YFL010W-A.score AUA1|YFL010W-A.strain.pval AUA1|YFL010W-A.strain.significant AUA1|YFL010W-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2934 9036370 36.88 µM 6.21167798151637 1.03486583616755e-09 yes 1 2.62108849601721e-10 9 6462800
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 5.57898582257884 3.72255221523231e-08 yes 2 1.20962477977172e-08 3 521171
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 4.7567269722157 2.27517823297218e-06 yes 3 9.83784964897145e-07 10 688664
SGTC_1097 itavastatin 7.23 µM 4.71993524672353 2.69609332569213e-06 yes 4 1.17959866044926e-06 11 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3306 9127676 59.7925 µM 4.53589266962578 6.18812938266789e-06 yes 5 2.8680173674781e-06 12 41905287
SGTC_3213 9129884 49.47 µM 4.50535472167952 7.08193082979615e-06 yes 6 3.31310798918448e-06 14 17190742
SGTC_2070 5230947 200 µM 4.32828895880793 1.52308033376998e-05 yes 7 7.51361153350984e-06 3 2835538
SGTC_669 0108-0021 26.2 µM 4.25015353912353 2.11641803554541e-05 yes 8 1.06812014872924e-05 66 17201
SGTC_1930 st074634 34.3 µM 4.20531045796428 2.54994544669212e-05 yes 9 1.30362006986493e-05 31 684253 YOR116C RPO31
SGTC_1590 st077108 57.8 µM 4.09422047875343 4.01475439017912e-05 yes 10 2.11795544694613e-05 6 5489485
SGTC_2815 7968870 71.43 µM 3.99153160964904 6.04824742328369e-05 yes 11 3.28239680162352e-05 21 2977326 YHR190W ERG9
SGTC_1509 1326-1131 80 µM 3.92880804003688 7.73269797864003e-05 yes 12 4.2683974206467e-05 13 768313
SGTC_1146 3579-1023 7 µM 3.91282429684755 8.22770648519395e-05 yes 13 4.56114547759715e-05 16 X1146
SGTC_2423 st077119 87.2 µM 3.87845767144533 9.39475288060278e-05 yes 14 5.25604062796252e-05 11 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2412 st077135 33.4 µM 3.87555544165758 9.50012520619219e-05 yes 15 5.31908767778152e-05 27 13258915
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.81459199922363 0.000119875453076118 yes 16 6.82040566320421e-05 57 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2424 5537928 59.2 µM 3.8001054425802 0.000126625256617076 yes 17 7.23172664544383e-05 42 5382802
SGTC_1773 st048542 73.5835 µM 3.71961380353599 0.000171093972725348 yes 18 9.97638152981538e-05 53 3237138
SGTC_2004 4023728 41.89 µM 3.70724294828751 0.000179103296824889 yes 19 0.000104763958082465 32 360084 YDR527W RBA50
SGTC_2195 6536160 144.242 µM 3.7031439240087 0.00018183357240921 yes 20 0.000106471996216279 16 3834386
SGTC_2154 5570129 200 µM 3.67450287992697 0.000202024452524559 yes 21 0.000119156478229207 23 673366
SGTC_2561 acetosyringone 100 µM 3.61649530170429 0.000249492678706444 yes 22 0.000149309367632304 37 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1045 1348-1485 165 µM 3.60961031686607 0.000255770622762296 yes 23 0.000153328669339066 47 6810614
SGTC_1806 st050005 60.3 µM 3.58835684832015 0.000276091408247511 yes 24 0.000166384311484101 21 5194765
SGTC_2082 5219693 150 µM 3.446114175339 0.000455843971502059 yes 25 0.000284355010856619 44 2834649
SGTC_1774 st048371 48.465 µM 3.44165441762249 0.00046293371805504 yes 26 0.000289084185357448 38 4242727
SGTC_674 0498-0004 451 µM 3.43915760871336 0.000466947409864427 yes 27 0.000291763701603477 36 4231473
SGTC_3254 9136651 49.47 µM 3.37956112082688 0.000572863740727925 yes 28 0.000363008311278083 40 16454030
SGTC_2543 pimpinellin 60.67 µM 3.36920823123899 0.000593384905737312 yes 29 0.000376922273708962 38 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2576 guaiol 23.12 µM 3.36648538370544 0.000598893733406098 yes 30 0.000380663083469133 51 227829
SGTC_1407 3909-7909 12.3 µM 3.32458244231871 0.000689851704497846 yes 31 0.000442755241820669 31 4411780
SGTC_2966 9084041 48.03 µM 3.2779706974381 0.000805893642482763 yes 32 0.000522781244132085 64 17741380
SGTC_364 0083-0097 67.7 µM 3.24781896983097 0.000890258473337318 yes 33 0.000581466175456579 51 5207356
SGTC_2157 5649910 96.377 µM 3.22820517950078 0.000949418370559117 yes 34 0.000622847951008072 48 2858091
SGTC_2062 5245942 200 µM 3.22675591551485 0.000953929857668677 yes 35 0.000626011068404778 42 1376160
SGTC_1866 st057638 64 µM 3.20154698414911 0.00103562053579636 no 36 0.000683458906485814 31 688802
SGTC_1054 3429-0080 167 µM 3.17518347241801 0.00112787679584563 no 37 0.000748708946934655 54 1162877
SGTC_3111 9122088 49.47 µM 3.1629975256645 0.0011730144450133 no 38 0.000780768294125586 16 16876704
SGTC_1027 k015-0025 8.67 µM 3.140855841122 0.00125928514607156 no 39 0.000842274639493238 58 3598955
SGTC_1767 st044992 70.3 µM 3.06155163216968 0.00161805621525866 no 40 0.00110096506110451 56 9600693
SGTC_1005 4092-0690 4.4 µM 3.05161326351994 0.00166905138422095 no 41 0.00113807577961993 69 1529343
SGTC_424 splitomicin 100 mM 3.01863048146324 0.0018489555973477 no 42 0.00126960015581945 66 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2342 7990637 118.86 µM 3.01223386893069 0.00188582284096872 no 43 0.00129666358932778 85 2033102 YER133W GLC7
SGTC_2384 9036245 200 µM 2.9903289113869 0.0020171906604602 no 44 0.00139338597041079 74 6462766
SGTC_2206 7254556 146.969 µM 2.97271412071979 0.00212879628388386 no 45 0.00147589620923423 19 4398905
SGTC_3044 9093193 49.47 µM 2.96359043260167 0.00218877821446086 no 46 0.00152036350471788 77 25236277
SGTC_3090 9117696 49.47 µM 2.93139199863797 0.00241290254047239 no 47 0.00168723338994443 50 7923821
SGTC_517 1365-0151 113 µM 2.91091384122719 0.00256604453915527 no 48 0.00180186688068184 82 768657
SGTC_2978 9011784 42.97 µM 2.90830895333651 0.00258614184279781 no 49 0.00181694567267844 94 2994934
SGTC_2367 9070478 135.38 µM 2.89521163987429 0.00268936232563403 no 50 0.00189451487732302 88 572802
SGTC_137 0438-0332 85.389 µM 2.88643957173503 0.00276056045794265 no 51 0.00194813779739939 203 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_68 0986-0284 82.829 µM 2.88477711106262 0.0027742439437153 no 52 0.0019584543399227 144 423278 YIL048W NEO1
SGTC_2136 5328288 199.296 µM 2.87549543549975 0.00285177108585946 no 53 0.0020169698906055 59 262395
SGTC_1961 st076550 68.7 µM 2.87357757021879 0.00286803199787034 no 54 0.00202925699808685 61 1579337
SGTC_1770 st043884 66.3 µM 2.86096615289455 0.00297705870716793 no 55 0.00211176070103446 62 670149
SGTC_1085 doxorubicin 7.67 µM 2.85493157738599 0.00303053760989259 no 56 0.00215230508513416 77 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1510 1123-0200 71.5 µM 2.84273967648677 0.00314123141070444 no 57 0.00223637934653632 111 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2311 7694451 200 µM 2.84255913335252 0.00314289761174861 no 58 0.00223764641175754 77 2163142
SGTC_2937 9044753 11.33 µM 2.83841183159557 0.00318139201936448 no 59 0.00226693215641365 98 6465530 YGL099W LSG1
SGTC_2433 5607874 27.82 µM 2.81171104462994 0.0034395463403931 no 60 0.00246393754415715 85 2252428
SGTC_57 miconazole 162.5 nM 2.7639091735249 0.00394909611396793 no 61 0.00285567172899573 78 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1018 4259-0013 28.1 µM 2.7632975931092 0.00395603184053069 no 62 0.00286102847226937 73 6801262
SGTC_864 0469-0573 172 µM 2.73986893365125 0.00423008043612376 no 63 0.00307318446840467 86 689425
SGTC_165 k038-0023 64.381 µM 2.72069832383776 0.00446682106458608 no 64 0.00325720909697831 172 46368543
SGTC_1676 st018489 23.4 µM 2.70916929440578 0.00461482793518734 no 65 0.00337259559988466 105 3696235
SGTC_2628 lathosterol 100 µM 2.70173702843889 0.00471254670621853 no 66 0.00344891473341107 102 6710616
SGTC_430 0958-0115 16.4 µM 2.69328357145779 0.00482593204734184 no 67 0.00353760321236285 107 6833180
SGTC_484 loperamide 105 µM 2.65942163484181 0.00530488257305877 no 68 0.00391374685192859 21 3955 An opioid-receptor agonist.
SGTC_2178 5812956 200 µM 2.65706683626311 0.00533971033217618 no 69 0.00394119070288611 77 5403383
SGTC_3251 9135047 49.47 µM 2.65501561806075 0.00537021363657014 no 70 0.00396523683528806 46 17682963
SGTC_572 0960-0087 17.7 µM 2.6530956028586 0.00539890611886799 no 71 0.00398786386476593 132 6796365
SGTC_2265 7929201 200 µM 2.64249480467676 0.00555978996129548 no 72 0.00411488639425123 101 1265108
SGTC_2774 tamoxifen 10.92 µM 2.63969099333559 0.00560304817526298 no 73 0.00414908252621953 86 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.61191258431885 0.00604804154463547 no 74 0.0045018636459514 136 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2143 5623677 140.463 µM 2.60587483269298 0.00614880892865918 no 75 0.00458199715199778 47 5375313
SGTC_3013 9080133 71.4286 µM 2.58675354673899 0.00647781755434785 no 76 0.00484424306869833 109 17050193
SGTC_798 1287-0182 476 µM 2.58581689533638 0.00649432677307446 no 77 0.00485742618878387 111 1649755
SGTC_2268 7933382 153.85 µM 2.58424511719227 0.00652211424190662 no 78 0.00487962041630229 137 935025 YOR257W CDC31
SGTC_1616 st002734 56.1 µM 2.56992832947702 0.00678010123181122 no 79 0.00508597784367182 123 4026101
SGTC_921 1561-0023 372 µM 2.55784516978273 0.00700481171653192 no 80 0.00526614872502554 112 24050882
SGTC_3116 9124943 49.47 µM 2.54667094738007 0.00721844311153548 no 81 0.00543779647103244 98 41905195 YPL160W CDC60
SGTC_3016 9080866 49.47 µM 2.53767477550226 0.00739458813765108 no 82 0.00557958162017246 125 17066299
SGTC_174 3553-0389 74.3 µM 2.48498179861557 0.00850437615097113 no 83 0.00647790293256246 116 738071
SGTC_2145 5634607 200 µM 2.46476839373952 0.00896740518700403 no 84 0.00685509201733765 87 308662
SGTC_520 3584-0023 682 µM 2.4613616039173 0.00904758207206907 no 85 0.00692053930489683 127 1340790
SGTC_2696 st077691 74.316 µM 2.45546196120135 0.00918791246905733 no 86 0.00703518215065094 135 757133
SGTC_1513 0337-0559 19 µM 2.4507209202726 0.00930206113207738 no 87 0.00712852220787763 135 775073
SGTC_2292 7671323 168.05 µM 2.43714891118545 0.00963571799297585 no 88 0.00740179088914724 159 937504
SGTC_1177 0983-0204 23.6 µM 2.42056202206559 0.0100576586572175 no 89 0.00774826775126646 114 766818
SGTC_3309 9129340 25.759 µM 2.41470607837688 0.0102104280832544 no 90 0.00787395587481491 114 17158987
SGTC_1486 3970-0793 4.53 µM 2.41126496582134 0.0103011404839938 no 91 0.00794864723285829 81 2844330
SGTC_1807 st050092 58.9 µM 2.38189752608159 0.0111043173240375 no 92 0.00861184479572791 130 5008496
SGTC_3151 9099821 49.47 µM 2.36135439753001 0.0116980359590889 no 93 0.00910416027011232 135 17174189
SGTC_2376 9072922 81.32 µM 2.34983345575002 0.0120429154355875 no 94 0.00939090630633393 181 17087968
SGTC_2682 pyrogallin 40.03 µM 2.34753287087614 0.0121128296793302 no 95 0.00944910278358297 166 822798 An ATP competetive kinase inhibitor.
SGTC_2857 9024691 58.44 µM 2.34643542352905 0.0121463046236945 no 96 0.0094769751728806 141 16478292
SGTC_1488 4013-0813 75.9 µM 2.32504648645876 0.0128149175370281 no 97 0.0100347373138346 90 2910057
SGTC_1620 st003704 16.5 µM 2.32504147094775 0.0128150779813073 no 98 0.0100348713939246 114 2834414
SGTC_2582 agaric acid 100 µM 2.32230581699649 0.0129028498624017 no 99 0.0101082372776179 572 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_749 1000-0129 128 µM 2.31505474815219 0.0131380156439088 no 100 0.0103049680372284 151 708470
SGTC_2328 6201408 200 µM 2.3007888003603 0.0136115161615464 no 101 0.0107017859032018 149 2890418
SGTC_770 0389-1121 67.2 µM 2.29463780896812 0.0138201741574181 no 102 0.0108769448007115 185 6753108
SGTC_2129 girgensonine 121.053 µM 2.27453290868392 0.0145215417345898 no 103 0.0114669823953838 182 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1571 st070080 73.4 µM 2.26221460675791 0.0149662354788118 no 104 0.0118420736421673 148 4315245
SGTC_234 nsc-17383 10.7 µM 2.25414267185928 0.0152639411300778 no 105 0.0120935969622583 169 408974
SGTC_1843 st055809 45.5 µM 2.25375415614559 0.0152783976029047 no 106 0.0121058191550689 148 16413835
SGTC_1881 5652484 16 µM 2.24329536506933 0.0156720070097016 no 107 0.0124388870333206 164 2255129
SGTC_1165 k072-0275 30.3 µM 2.24044327914955 0.0157808412664374 no 108 0.0125310796188295 170 6153523 YGL055W OLE1
SGTC_2688 kanamycin b 96.69 µM 2.2329774605351 0.0160688074333309 no 109 0.0127752153847325 720 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2185 6113692 200 µM 2.22315665916984 0.0164544574399234 no 110 0.0131026190924661 140 874150
SGTC_2791 5663188 71.43 µM 2.21480264450219 0.0167887193832472 no 111 0.0133868068194027 165 54690634
SGTC_2763 lisinopril 49.32 µM 2.21266841228647 0.0168750402098531 no 112 0.0134602573374245 113 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.21222061479413 0.016893199850386 no 113 0.0134757125640769 222 91467 include heat shock
SGTC_1157 4092-0394 27.6 µM 2.2086840760137 0.0170372059741994 no 114 0.0135983113950891 194 3659885
SGTC_857 0438-0306 1.35 µM 2.20848457730908 0.0170453606356639 no 115 0.013605255873374 132 4686136
SGTC_722 3534-0461 190 µM 2.17531106611442 0.0184485708616481 no 116 0.0148034069112554 191 658262
SGTC_3073 9114972 49.47 µM 2.17207490977255 0.0185905802145899 no 117 0.0149250065598428 148 41905075
SGTC_577 r071-0003 38.6 µM 2.16734493949106 0.0187998147982152 no 118 0.0151042811301596 280 4568517 YMR134W ERG29
SGTC_342 k048-0088 23.3 µM 2.15835924455512 0.0192028272781594 no 119 0.0154499559114408 169 6820570
SGTC_1340 1486-1359 257 µM 2.1429037335159 0.0199131945308872 no 120 0.0160604145660359 181 4309068
SGTC_575 k072-0246 11.9 µM 2.13895000024642 0.0200984572989254 no 121 0.0162198589895006 190 6796779
SGTC_1025 k007-0731 70 µM 2.13802759891538 0.0201418885726876 no 122 0.0162572516646073 171 6256118
SGTC_3139 9095020 49.47 µM 2.13175915412779 0.0204391516245583 no 123 0.0165133255428392 106 25236292
SGTC_1188 1403-0014 4.57 µM 2.11784934818973 0.0211120835993567 no 124 0.0170939142391969 263 9614867
SGTC_3215 9129942 49.47 µM 2.11389908647181 0.0213065737846366 no 125 0.0172619436433945 142 17682944
SGTC_566 0958-0068 16.5 µM 2.103945443692 0.0218033681269998 no 126 0.0176916031329388 163 6815365
SGTC_606 k015-0008 38.6 µM 2.09949728843182 0.0220285222963082 no 127 0.0178865432997635 207 1970475
SGTC_1308 1187-1617 41.4 µM 2.09679987452888 0.0221660121066197 no 128 0.0180056473571129 238 2882570
SGTC_3219 9131112 49.47 µM 2.0897795143755 0.0225272456217379 no 129 0.0183188051952954 197 17612988 YMR079W SEC14
SGTC_2863 9028737 58.44 µM 2.08078417552996 0.0229973451676777 no 130 0.0187268326183556 131 6460917
SGTC_2674 ligustilide 100 µM 2.07739309840327 0.0231766957671977 no 131 0.0188826463342779 139 5319022 A signalling regulator.
SGTC_3002 9075603 71.4286 µM 2.06694682502618 0.0237366055763862 no 132 0.0193695824072878 212 20105405
SGTC_2589 lobaric acid 100 µM 2.06263949784919 0.0239707632533684 no 133 0.019573446067056 213 73157 A novel microtubule depolymerizer.
SGTC_1803 st050068 52.4 µM 2.06256798800745 0.0239746670394246 no 134 0.0195768459107366 474 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2068 5226020 147 µM 2.06046160692407 0.0240898961267452 no 135 0.0196772162828365 251 1810509
SGTC_3253 9135987 49.47 µM 2.0510343917988 0.0246113262434083 no 136 0.0201317988239874 138 4182430
SGTC_799 1310-0557 151 µM 2.04503371161643 0.024948138533103 no 137 0.0204257673262883 217 5354492
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.03886486416347 0.0252984101581733 no 138 0.0207317582211672 227 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_36 0335-0881 14.2 µM 2.02812755415638 0.0259179079905796 no 139 0.0212736156835738 320 23828853
SGTC_665 3914-0008 307 µM 2.02023105311426 0.026381559519742 no 140 0.0216797133228617 220 1069549
SGTC_2369 9071472 200 µM 2.0181644537081 0.0265040402616948 no 141 0.0217870684159669 223 17296037
SGTC_1841 st054148 70 µM 2.01779444520773 0.0265260195553541 no 142 0.0218063368253326 189 675442
SGTC_1665 st014639 11.4 µM 2.01439397062618 0.0267287289913731 no 143 0.0219840934432181 244 981133 YIL048W NEO1
SGTC_2972 9093619 59.92 µM 2.0105506391275 0.0269593938224659 no 144 0.022186471153095 215 25236256
SGTC_2329 6138490 200 µM 2.00717969773745 0.0271630728243551 no 145 0.0223652662786052 207 720019
SGTC_3210 9128157 49.47 µM 2.00038228447529 0.0275776919881206 no 146 0.0227294999286835 268 17590849
SGTC_287 k060-0039 29.6 µM 1.99969714875332 0.0276197740710844 no 147 0.0227664881324381 193 5861974
SGTC_3333 9141820 12.094 µM 1.98908828943868 0.0282782461590757 no 148 0.0233457293413666 182 1939433
SGTC_1653 st012112 65 µM 1.97982251453373 0.028863996143292 no 149 0.0238617377849305 199 720429
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.97935316634654 0.0288939331091213 no 150 0.0238881287674607 215 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2938 9059746 27.26 µM 1.97797685447728 0.0289818688035665 no 151 0.0239656589046047 230 6471769
SGTC_998 3996-0085 177 µM 1.97667155395496 0.0290654728021921 no 152 0.0240393841105136 234 715391
SGTC_2614 arthonioic acid 13.39 µM 1.97547251023947 0.029142447585161 no 153 0.0241072756155699 213 6710684
SGTC_3250 9135583 49.47 µM 1.97245592556156 0.0293368519583472 no 154 0.0242787914801768 176 7699353
SGTC_1622 st003707 19.4 µM 1.96483620883773 0.029832706045951 no 155 0.0247165989411616 290 10140899
SGTC_951 1171-0579 82.7 µM 1.9642882868714 0.0298686284914863 no 156 0.0247483346328834 336 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1239 0337-0584 35.4 µM 1.96414958914433 0.0298777273754609 no 157 0.0247563734374844 293 914301 YML130C ERO1
SGTC_2977 9011197 71.43 µM 1.95410795062321 0.0305426164239439 no 158 0.0253442260173246 171 2704722
SGTC_2247 cerulenin 830 nM 1.9389512384386 0.0315693638921831 no 159 0.026253637976803 229 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_785 1270-0111 65.3 µM 1.93692087597409 0.0317090470853479 no 160 0.0263775080809379 277 6741994
SGTC_2181 6316240 54.2555 µM 1.93619737207849 0.0317589453541767 no 161 0.0264217661115079 219 12779990
SGTC_2736 butenafine 14.65 µM 1.92740396702618 0.0323706067619663 no 162 0.0269646528147433 277 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_474 dl-dihydrosphingosine 5 µM 1.90681440814597 0.0338408854196321 no 163 0.028272312447259 264 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2825 7998094 58.44 µM 1.90276346875202 0.0341365310869641 no 164 0.0285357079976411 241 2987815
SGTC_16 erodoxin 22.806 µM 1.90248067250083 0.0341572491737485 no 165 0.0285541716263575 331 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2752 diclazuril 33.15 µM 1.89622095594287 0.0346184987208798 no 166 0.0289654166292835 415 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2390 9097792 176.6 µM 1.89427191800438 0.0347631543847808 no 167 0.0290944632207815 218 4497149
SGTC_689 0833-0039 98 µM 1.88743890170452 0.0352742191025966 no 168 0.0295506584566133 252 5374726
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.88721787746579 0.0352908526161555 no 169 0.0295655133542782 214 2724278 An inhibitor of dopamine biosynthesis.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.88514465931106 0.0354471891955129 no 170 0.0297051549876778 345 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1733 st037357 54.9 µM 1.88429189563602 0.0355116587486383 no 171 0.0297627515283988 283 1272339 YGL099W LSG1
SGTC_712 r015-0009 80.6 µM 1.88376315974759 0.0355516798245558 no 172 0.0297985094087912 222 6813872 YLR060W FRS1
SGTC_2266 7929956 200 µM 1.88174254726053 0.0357049648177141 no 173 0.0299354899254946 272 2967153
SGTC_124 0136-0217 7.121 µM 1.87483224531742 0.0362332834155897 no 174 0.0304079028000379 301 3976905
SGTC_1400 3771-8998 51.5 µM 1.87169335450375 0.0364753684074766 no 175 0.0306245197336134 188 670767
SGTC_3120 9124077 49.47 µM 1.8680122637227 0.0367609547668571 no 176 0.0308801807743459 213 18774327 YGL155W CDC43
SGTC_1136 pergolide 1.05886 µM 1.8665910169341 0.0368717061081666 no 177 0.0309793615055579 364 47811 A dopamine receptor agonist.
SGTC_35 0133-0054 64.071 µM 1.85678044292552 0.0376436618114769 no 178 0.0316711986175135 247 99677
SGTC_583 1488-1091 88.9 µM 1.84936589278252 0.038235796366401 no 179 0.0322024984634299 324 4303273
SGTC_2278 7948257 134.34 µM 1.84681651943261 0.0384411385958861 no 180 0.0323868684307219 255 1247028
SGTC_350 k064-0020 19.8 µM 1.84542155706325 0.0385538773974689 no 181 0.0324881198404249 302 2790705
SGTC_1951 sophoraflavanone G 9.2 µM 1.84151078643128 0.0388713772940277 no 182 0.0327733706874389 288 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3181 9108277 49.47 µM 1.84150001931916 0.0388722543635659 no 183 0.0327741588796523 262 17097298
SGTC_1338 1486-1223 76 µM 1.84141809821858 0.0388789280365232 no 184 0.0327801563173699 272 3444526
SGTC_2657 nystatin 74.44 µM 1.8408109931107 0.0389284147216262 no 185 0.0328246306422659 269 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_421 streptovitacin 30 mM 1.8360668203841 0.0393168932791229 no 186 0.0331738873629698 305 91467 include heat shock
SGTC_481 bay k-8644 50 µM 1.82531587167085 0.040208918678617 no 187 0.0339766882091198 264 2303 A calcium channel antagonist.
SGTC_2319 6033012 152.6 µM 1.81447616926606 0.0411248820304332 no 188 0.0348022241860558 233 847246
SGTC_1037 k284-1091 78.7 µM 1.80727979203669 0.041742273679424 no 189 0.0353593326058069 238 3334711
SGTC_3249 9135183 49.47 µM 1.8068345506486 0.0417807171009146 no 190 0.0353940399133047 287 4902779
SGTC_298 1391-0729 10 µM 1.80608980452553 0.0418450847090163 no 191 0.0354521565579463 246 3237558
SGTC_1726 st035556 14.5795 µM 1.8048932823788 0.0419486669498702 no 192 0.0355456916013309 328 5919439
SGTC_1966 st070145 16.1 µM 1.80396391904375 0.0420292645542818 no 193 0.0356184817063715 274 3748532
SGTC_685 1278-0033 54.9 µM 1.80243643826959 0.0421620052470507 no 194 0.0357383832993718 312 3590572
SGTC_1163 k060-0048 49.9 µM 1.80033726799408 0.0423449800080469 no 195 0.035903699832774 318 6809982
SGTC_2121 5257820 149.641 µM 1.79989068733259 0.0423839890831596 no 196 0.0359389502144168 292 791256
SGTC_2330 7979373 200 µM 1.79736757192676 0.042604931037754 no 197 0.0361386426529921 337 1863007
SGTC_2975 9084847 53.72 µM 1.79354057976413 0.0429418262723444 no 198 0.0364432640219133 302 27211724
SGTC_1725 st036284 20.55 µM 1.78745590811746 0.0434818970066501 no 199 0.0369319161939456 324 707914
SGTC_233 rapamycin 362 pM 1.7815246383394 0.0440136161145136 no 200 0.0374133917665294 275 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_755 1995-0008 37.3 µM 1.77584956901524 0.0445272640939799 no 201 0.0378788575187394 270 689533
SGTC_551 k048-0028 34.9 µM 1.77570423355167 0.0445404814919029 no 202 0.0378908396236494 318 6836383
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.76846220048293 0.0452031141072213 no 203 0.0384918330138404 270 279621
SGTC_3071 9117417 49.47 µM 1.76845550757145 0.0452037301446791 no 204 0.0384923920098669 221 45595590 YGL055W OLE1
SGTC_2142 5622915 118.518 µM 1.76622001590506 0.0454098703257329 no 205 0.0386794721336924 242 5322196
SGTC_1160 4092-0570 10.5 µM 1.76223267368308 0.0457794293714096 no 206 0.0390149968911962 332 4994975
SGTC_2071 5230951 39.92 µM 1.75758881916721 0.0462128788039042 no 207 0.0394087485679788 311 1799272
SGTC_1196 1588-0294 184 µM 1.74862334113147 0.0470590213706885 no 208 0.0401780744502079 276 6144269
SGTC_2737 bleomycin 30.5 nM 1.74540815983585 0.0473654724203806 no 209 0.0404569231555789 365 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_795 0685-0265 78 µM 1.74227167082532 0.047665961898224 no 210 0.0407304590302381 326 302754
SGTC_860 0443-0016 25.1 µM 1.74030418909197 0.0478552332556281 no 211 0.0409028094387318 299 5337942
SGTC_1004 4084-0029 199 µM 1.73749191228014 0.0481268179006726 no 212 0.0411501901783954 315 716894 YLR208W SEC13
SGTC_2109 5483026 200 µM 1.73729498542905 0.0481458814528508 no 213 0.0411675581156085 354 759335
SGTC_1455 4262-0120 131 µM 1.71386361458114 0.0504576313209207 no 214 0.0432768884163976 326 1529587
SGTC_1609 st001574 46.4 µM 1.71126162473118 0.0507197107082072 no 215 0.043516413562891 305 3960012
SGTC_711 k292-0785 179 µM 1.7081705590144 0.0510324587164127 no 216 0.0438023498110979 318 4146315
SGTC_2396 5342950 42.78 µM 1.69352376184954 0.052535313951049 no 217 0.0451779079154242 382 1886677
SGTC_1379 2144-0755 36.5 µM 1.69192007579711 0.0527019742854307 no 218 0.045330606808137 358 5392327
SGTC_51 1013-0126 23.419 µM 1.68964548705565 0.0529390762081303 no 219 0.0455478990539906 311 1627850
SGTC_1913 st060213 96.1 µM 1.68764954149078 0.0531478287316883 no 220 0.0457392615941257 374 688959
SGTC_2194 5927483 104.545 µM 1.68312282220781 0.0536236890644369 no 221 0.0461756586394016 358 760979
SGTC_1104 tacrolimus 29.8 µM 1.67554705221115 0.0544276174191599 no 222 0.0469134736859001 344 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2002 4023503 131 µM 1.67483629312411 0.0545035286052005 no 223 0.0469831779483635 443 4736863 YCR052W RSC6
SGTC_2119 5528445 120.635 µM 1.67236976324208 0.0547676110023344 no 224 0.0472257153449221 328 791935
SGTC_1702 st027038 51 µM 1.67015933602824 0.0550051318816019 no 225 0.0474439215083452 354 5521182
SGTC_1667 st014849 34.6 µM 1.66177026158852 0.0559139918445411 no 226 0.0482794235518274 320 5348460
SGTC_1035 k081-0041 55.2 µM 1.65725623302218 0.0564079144441378 no 227 0.0487338409399145 359 731709
SGTC_2264 7948757 110.76 µM 1.65487277504454 0.0566700949053463 no 228 0.0489751539052721 332 2971411
SGTC_2007 4011539 71.82 µM 1.64797900174917 0.0574338162360761 no 229 0.0496784901074447 380 45595301
SGTC_2630 antimycin a 100 µM 1.6330206952569 0.0591187950058981 no 230 0.0512323220812749 399 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1703 st026983 48.3 µM 1.63141983348005 0.0593013974641032 no 231 0.0514008813654113 357 1104023
SGTC_2146 5545642 200 µM 1.62681592679778 0.0598290078057124 no 232 0.0518880989917864 323 825326
SGTC_1334 1486-0610 236 µM 1.6264379741705 0.0598724842051217 no 233 0.0519282590418379 373 3742339
SGTC_1769 st044406 64.4 µM 1.61843001436906 0.060799479540895 no 234 0.0527849790010814 385 670903
SGTC_1800 st050079 29.0735 µM 1.61591146504259 0.0610933334368277 no 235 0.053056728217807 554 3645560
SGTC_231 b-estradiol 524 µM 1.61513623959382 0.0611840066050753 no 236 0.0531405972747859 286 450 A steroid.
SGTC_1848 st056003 16.4 µM 1.61483725711004 0.0612190047639683 no 237 0.0531729712660973 360 146492
SGTC_3164 9100705 49.47 µM 1.61232185099164 0.0615140718216109 no 238 0.0534459603882869 280 17174235
SGTC_1960 st011366 51.8 µM 1.60867081919618 0.061944326920362 no 239 0.0538441698766993 318 3972846
SGTC_2160 5660466 132.927 µM 1.60656577543461 0.0621934606569393 no 240 0.0540748276242816 355 2859134
SGTC_142 0335-0849 62.6745 µM 1.60139512801242 0.0628087290467804 no 241 0.054644715573079 521 3889043 YPR107C YTH1
SGTC_3133 9127736 49.47 µM 1.60037606949444 0.0629305470006668 no 242 0.0547575903056767 366 27243420
SGTC_1983 st071813 46.9 µM 1.59806654709743 0.0632073078452692 no 243 0.0550140838366938 368 11838595
SGTC_1761 st044296 37 µM 1.59360933728261 0.0637441146590207 no 244 0.0555117809199681 379 1826700
SGTC_3207 9114163 49.47 µM 1.59162844250589 0.063983820338349 no 245 0.0557341076780169 429 849233
SGTC_1288 0973-0013 65.5 µM 1.59124875113697 0.0640298462791727 no 246 0.0557768026776154 377 4315430
SGTC_483 fpl-64176 144 µM 1.59011699118433 0.0641671902158566 no 247 0.0559042183471641 282 3423
SGTC_3255 9139072 49.47 µM 1.5894412745495 0.0642493004491893 no 248 0.055980401203821 364 17646060
SGTC_944 3370-0224 231 µM 1.5890944238835 0.0642914799839037 no 249 0.0560195382564621 372 4580514
SGTC_661 1304-0007 33.6 µM 1.58880957675238 0.0643261355340074 no 250 0.0560516952481091 353 3117130
SGTC_917 harmaline 728.087 nM 1.58461324484656 0.0648383605752733 no 251 0.0565271168991406 392 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1935 st074532 41.6 µM 1.58005019295452 0.0653989373258012 no 252 0.0570476861314146 458 2829742
SGTC_1456 k015-0012 13 µM 1.57358727046036 0.0661993393991011 no 253 0.057791449023234 427 2989616
SGTC_2467 5474540 200 µM 1.57263365665545 0.0663180795567647 no 254 0.057901834881501 399 5413519
SGTC_87 0100-0052 35.5 µM 1.56922698602761 0.0667436118489558 no 255 0.0582975291552833 622 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2807 7945238 51.95 µM 1.56766874325718 0.0669389571456016 no 256 0.0584792299408079 407 17148797
SGTC_1197 1601-0112 267 µM 1.56639985667649 0.067098354469309 no 257 0.0586275182483284 411 7350313
SGTC_2406 ethylparaben 405.7 µM 1.56489707012417 0.0672875137612785 no 258 0.0588035228979731 344 8434 A possible steroid mimic.
SGTC_1597 7-benzyloxygramine 47.5 µM 1.56315826541655 0.0675068953734896 no 259 0.059007686895987 556 260807
SGTC_3119 9125183 49.47 µM 1.56077273056893 0.0678087725039115 no 260 0.0592886918594276 255 22695334
SGTC_178 4092-0806 87.505 µM 1.56002516644156 0.0679035871397191 no 261 0.0593769670545031 508 2169044
SGTC_3348 9149464 3.537 µM 1.55761373929511 0.0682101297700677 no 262 0.0596624198849502 376 1951442
SGTC_1294 1000-1494 117 µM 1.55091469817609 0.069067323059012 no 263 0.0604610637829376 384 712797 YDL207W GLE1
SGTC_1680 diphenhydramine 100 µM 1.53496816368688 0.0711411889486037 no 264 0.0623958241895536 407 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2256 7954252 200 µM 1.53399404042315 0.0712694079834454 no 265 0.0625155594621145 307 2972920
SGTC_2616 abietic acid 100 µM 1.52358744810923 0.0726502691123471 no 266 0.0638059003175602 433 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_482 fipronil 114 µM 1.523384858509 0.0726773528221669 no 267 0.0638312239664623 289 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1787 fluconazole 80 µM 1.51910545291206 0.0732512644920606 no 268 0.0643679771980593 492 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_578 3460-0051 92 µM 1.51865996580178 0.0733112075247081 no 269 0.0644240542935172 455 2876744
SGTC_2244 6635614 200 µM 1.51755492358671 0.0734600597295009 no 270 0.0645633188270266 253 836499
SGTC_88 0180-0332 8.668 µM 1.51649031470047 0.0736036839504268 no 271 0.0646977087547132 415 3101745
SGTC_1828 st055811 49 µM 1.5132245497448 0.0740456011915407 no 272 0.0651113151667691 359 5877589
SGTC_1346 1488-2224 62.4 µM 1.51076150942976 0.0743802339707038 no 273 0.0654246123155725 411 3722427
SGTC_668 1682-0499 62.6 µM 1.50460814860937 0.0752212847639669 no 274 0.0662124250302646 493 682214
SGTC_1408 3909-7976 48.8 µM 1.50375580289216 0.0753383541562818 no 275 0.0663221275145097 462 24152374
SGTC_1859 st055998 20 µM 1.50214634865889 0.0755597907900586 no 276 0.0665296585816337 438 676301
SGTC_2516 gossypol 71.55 µM 1.49913366152683 0.0759756236090179 no 277 0.0669194802688072 433 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1779 st039427 55 µM 1.49905671416989 0.0759862672133473 no 278 0.0669294598366593 504 1124498
SGTC_2954 9074818 52.69 µM 1.49840508093094 0.0760764487274428 no 279 0.067014018558321 431 16648742
SGTC_2335 9018011 154.17 µM 1.49824691461718 0.0760983501301704 no 280 0.0670345553535903 477 6458208
SGTC_2728 chlorpromazine 9.18 µM 1.49724078244002 0.0762377823655998 no 281 0.0671653086000535 304 2726 A thorazine and dopamine antagonist.
SGTC_1670 st016595 4.04 µM 1.49682092900067 0.0762960241363317 no 282 0.067219929493908 432 597879
SGTC_1613 st002381 52.1 µM 1.49265434624459 0.0768758461062932 no 283 0.0677638448029342 426 551167
SGTC_2374 9071832 200 µM 1.49143277519384 0.0770464734626114 no 284 0.0679239542467581 387 17381698
SGTC_250 brefeldin a 552.239 µM 1.49125141422767 0.0770718302301012 no 285 0.0679477498346388 348 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_117 lucigenin 22.078 µM 1.48641308633708 0.0777506390482004 no 286 0.0685849452490898 500 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_892 0929-0076 29 µM 1.48557419036092 0.0778687948972 no 287 0.0686958930322766 484 5751038
SGTC_940 3232-1287 54.8 µM 1.48485324445235 0.077970446684156 no 288 0.0687913519249296 423 1585493 YIL048W NEO1
SGTC_379 3970-0972 5.9 µM 1.47773773153106 0.0789791254864046 no 289 0.0697389954686749 438 2898042 YBL034C STU1
SGTC_788 1182-0090 188 µM 1.47646139183743 0.0791610972821192 no 290 0.0699100361850301 568 5715185
SGTC_2730 imipramine 71.33 µM 1.47510152763035 0.0793553265589553 no 291 0.0700926249110993 527 3696 A tricyclic antidepressant.
SGTC_1968 st069590 43.6 µM 1.47442188234033 0.0794525353276473 no 292 0.070184018147517 425 6384066
SGTC_1068 loratadine 26.9 µM 1.4744159801781 0.0794533799006524 no 293 0.0701848122241059 416 3957 A H1 histamine antagonist.
SGTC_3190 9110366 49.47 µM 1.47403422626723 0.0795080216105298 no 294 0.0702361880544482 357 17123768
SGTC_3173 9105693 49.47 µM 1.4731571817872 0.0796336636167907 no 295 0.0703543288462817 464 17096658
SGTC_3351 9150312 21.596 µM 1.47278942292995 0.0796863920080435 no 296 0.0704039126252254 452 4904905
SGTC_2667 digitoxin 100 µM 1.47139525969194 0.079886523692836 no 297 0.0705921273220337 325 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1863 st057641 20.1 µM 1.47125771721594 0.0799062884525303 no 298 0.0706107167575373 468 3921635
SGTC_1355 1499-0035 1.68 µM 1.47026723901609 0.0800487287044329 no 299 0.0707446951099148 435 1548538
SGTC_288 1315-0019 35.1 µM 1.46727517022248 0.0804801827021872 no 300 0.0711506076849855 447 6811474
SGTC_708 3448-5400 146 µM 1.46663252521819 0.0805730803824886 no 301 0.0712380235833727 467 3462195
SGTC_541 4513-1321 94 µM 1.46288485120949 0.0811164402495724 no 302 0.0717494449240961 441 747515
SGTC_3114 9122766 49.47 µM 1.46269808169591 0.0811435913544642 no 303 0.0717750056579526 424 17176985
SGTC_347 4534-1311 26.2 µM 1.462601413326 0.0811576469461382 no 304 0.0717882381533807 430 2862016
SGTC_1220 1838-0075 193 µM 1.46015620098205 0.0815137923496095 no 305 0.0721235748149467 452 5529645
SGTC_2870 9038528 12.99 µM 1.45475421729034 0.0823047679153408 no 306 0.0728686584737436 407 6463316
SGTC_2640 pentamidine 10.38 µM 1.45208498459908 0.0826977327080937 no 307 0.0732389882357489 497 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3226 9131256 49.47 µM 1.45064233877544 0.082910706157153 no 308 0.0734397396520197 288 17178073
SGTC_2787 5284540 71.43 µM 1.44992179600426 0.0830172320941501 no 309 0.07354016425532 452 736958
SGTC_3297 9117502 71.43 µM 1.44706390008717 0.0834407609985426 no 310 0.0739395137718894 403 7453720
SGTC_2212 7123476 200 µM 1.44406689378871 0.0838866478211343 no 311 0.0743600797559043 350 1085715
SGTC_3001 9076041 71.4286 µM 1.441275905772 0.0843034907157024 no 312 0.0747533757027415 451 16004211
SGTC_259 usnic acid 108.925 µM 1.43972237324948 0.0845361881443438 no 313 0.0749729804556863 466 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1771 st048882 4.1505 µM 1.43159673674798 0.0857611509280344 no 314 0.0761296320459683 440 4580403
SGTC_840 0245-0196 390 µM 1.42946582265979 0.0860845807663939 no 315 0.0764351956977456 507 3827528
SGTC_2107 5363541 170.161 µM 1.42821540604644 0.0862747931933323 no 316 0.0766149338081957 465 244052
SGTC_2322 7413319 38.22 µM 1.42309708603401 0.0870566655910424 no 317 0.0773540064913451 636 1840400
SGTC_1161 k007-0610 110 µM 1.41864199677232 0.0877415207406332 no 318 0.0780017077429341 575 5843850
SGTC_3292 9120825 59.784 µM 1.41857834519851 0.0877513345677069 no 319 0.0780109914237615 453 24824900
SGTC_3355 9151058 44.0485 µM 1.41774161077573 0.0878804187831258 no 320 0.0781331083940549 452 17015728
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.41345981850851 0.0885431942855099 no 321 0.0787602839512676 505 16486 A toxic proline analog.
SGTC_198 3454-2873 16.191 µM 1.412131307078 0.0887495886167056 no 322 0.0789556510327643 459 710957
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.40544166761817 0.089794321487453 no 323 0.0799449918484932 509 1377
SGTC_3180 9109287 49.47 µM 1.40398645131173 0.0900227909584817 no 324 0.080161442068649 422 18891271
SGTC_580 1123-0028 41 µM 1.40206429653003 0.0903252316298669 no 325 0.0804480237607759 545 1677248 YPR107C YTH1
SGTC_2297 7971671 152.32 µM 1.40081711125334 0.0905218727467583 no 326 0.0806343852016524 454 909016
SGTC_1804 st050076 49.1 µM 1.40021072633267 0.0906175949481832 no 327 0.0807251123679281 490 3895976
SGTC_1166 k206-0078 225 µM 1.39578521103591 0.0913184703779612 no 328 0.0813895925722121 516 5404595
SGTC_92 0063-0024 660.874 µM 1.39520570512677 0.0914105443661048 no 329 0.0814769085574438 528 3594437
SGTC_61 0978-8327 98.565 µM 1.39116711610246 0.0920541215451041 no 330 0.0820873782065201 500 6150059 YHR072W ERG7
SGTC_2903 5923464 63.88 µM 1.39017805483128 0.0922122455264205 no 331 0.0822374078154132 451 2876576
SGTC_2395 5646831 180.19 µM 1.38701783571452 0.0927188259934897 no 332 0.0827181621357838 480 6808628
SGTC_3065 9113888 49.47 µM 1.38596498331483 0.0928880535941136 no 333 0.0828787980860439 443 16648368
SGTC_199 4063-0024 41.6 µM 1.37836360420204 0.0941166232452256 no 334 0.0840455272927334 477 306215
SGTC_2600 tangeritin 87.95 µM 1.37708069878376 0.0943251492660939 no 335 0.0842436496900043 475 68077 A bioactive flavone.
SGTC_2748 diazoxide 86.69 µM 1.37430626800394 0.0947772756782542 no 336 0.0846733106161073 422 3019 A potassium channel activatior.
SGTC_1430 4049-0248 69.1 µM 1.37326750287744 0.0949469650420546 no 337 0.084834600652355 552 22774488
SGTC_1453 4237-0541 195 µM 1.37197462916036 0.095158477287215 no 338 0.0850356680051223 488 739892
SGTC_1159 4092-0538 61.2 µM 1.36999981723277 0.0954822231136112 no 339 0.0853434793482239 543 717301
SGTC_584 0986-0246 15.4 µM 1.36931781702873 0.0955942166706822 no 340 0.0854499754949077 552 53315 YDR232W HEM1
SGTC_1145 3546-0597 10.2 µM 1.36866938589257 0.0957007873539994 no 341 0.0855513220163807 523 875334
SGTC_2926 9010726 65.15 µM 1.36622803768855 0.0961028108981814 no 342 0.0859336999220566 516 2994293
SGTC_2345 9052315 157.45 µM 1.36068474961655 0.0970202471854305 no 343 0.0868066680237132 495 6469265
SGTC_1789 tunicamycin 25 nM 1.35924280090498 0.0972599457194929 no 344 0.0870348313133015 490 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_455 paf C-16 10 µM 1.35773221768385 0.097511519265148 no 345 0.0872743349221812 479 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1934 st074720 32.6 µM 1.3570267777363 0.0976291670525999 no 346 0.0873863511308541 569 17250992
SGTC_2223 6903751 107.57 µM 1.35181920876767 0.0985008663825211 no 347 0.0882165788341701 436 5598863
SGTC_2866 9034245 58.44 µM 1.34591425154587 0.0994961806804309 no 348 0.089165086065834 444 6462273
SGTC_17 0960-0276 49.807 µM 1.34572681655682 0.0995278938465582 no 349 0.0891953173435162 555 6821114
SGTC_2475 5812728 15.03 µM 1.34046535845529 0.100421125609326 no 350 0.0900470496786749 539 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2664 lyso-paf C-16 73.48 µM 1.33756030449173 0.100916812859558 no 351 0.0905199058711363 533 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_922 1866-0035 480 µM 1.33742303690628 0.100940278785641 no 352 0.0905422944662416 617 3156169
SGTC_996 3970-0799 1.8 µM 1.33610058518731 0.101166556015846 no 353 0.0907581993828915 691 6615648 YGL040C HEM2
SGTC_1078 idebenone 36.1 µM 1.33520595687848 0.101319840279642 no 354 0.0909044738834614 587 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2793 7325131 81.82 µM 1.33456173499549 0.101430325030912 no 355 0.0910099144290161 475 4176441
SGTC_2499 avocadenofuran 51.48 µM 1.3339094155584 0.101542287914611 no 356 0.0911167727198108 535 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1359 1582-0056 520 nM 1.33274349888002 0.101742627817104 no 357 0.0913079965628798 580 3661189
SGTC_321 4534-3890 65.3 µM 1.32989200207613 0.102233813755233 no 358 0.0917769284753109 519 699746
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.32869069273506 0.102441261459938 no 359 0.0919750184070489 439 77254
SGTC_2252 omeprazole 400 µM 1.32741086781041 0.102662604157009 no 360 0.0921864033089622 406 4594 A proton pump inhibitor.
SGTC_934 2950-0684 338 µM 1.32660882551709 0.102801492538722 no 361 0.0923190574452303 572 1121253
SGTC_3240 9133527 49.47 µM 1.32236694124733 0.103538323889132 no 362 0.0930229958143291 533 17617455
SGTC_19 0279-0214 38.434 µM 1.3203836880271 0.103884134338737 no 363 0.0933534734681943 636 3566274 YBR002C RER2
SGTC_310 1273-0058 1.06 µM 1.32034572214288 0.103890762431411 no 364 0.0933598083297675 761 2734232
SGTC_2429 5902844 64.44 µM 1.31900971134005 0.104124198835354 no 365 0.0935829329217613 547 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_938 3126-1755 342 µM 1.3179345383898 0.104312335939492 no 366 0.0937627812620712 563 1777771
SGTC_148 3253-0744 288.01 µM 1.31722392139085 0.104436817061194 no 367 0.093881788887945 512 6893655
SGTC_3182 9108849 49.47 µM 1.31336447591874 0.105114768870473 no 368 0.0945300809432289 562 17133045
SGTC_23 0213-0011 39.996 µM 1.30748745506744 0.106153237429043 no 369 0.0955236063632581 533 627608
SGTC_197 4544-0043 41.561 µM 1.30473071554654 0.106642898292062 no 370 0.0959922792925914 588 896523
SGTC_405 ebelactone b 50 µM 1.30337443548393 0.106884402536088 no 371 0.0962234799415388 557 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1479 0549-0158 134 µM 1.30163410884567 0.107194869194648 no 372 0.0965207470123078 608 5440202
SGTC_2647 atorvastatin 60.16 µM 1.30084297113962 0.107336219492452 no 373 0.0966561049499431 531 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2201 6605497 169.863 µM 1.29880696419878 0.107700604727302 no 374 0.0970050920291985 498 670741
SGTC_114 0364-0001 490.298 µM 1.29835350300582 0.107781882120465 no 375 0.0970829445170464 565 4003655
SGTC_2992 9074591 71.4286 µM 1.29662655011987 0.10809182190745 no 376 0.0973798563286631 532 17741321
SGTC_612 0302-0167 22.4 µM 1.29356635921125 0.108642615614307 no 377 0.0979076243845308 625 235821
SGTC_94 0334-0113 514.748 µM 1.29222537727833 0.108884609582571 no 378 0.0981395528682707 540 6795178
SGTC_782 0083-0095 30.5 µM 1.29135529200799 0.10904183255883 no 379 0.0982902529385942 612 3591729 An indicator and reagent.
SGTC_1311 1190-0148 100 µM 1.28983698199122 0.109316579345907 no 380 0.09855363231814 662 1961333
SGTC_463 ikarugamyin 104 µM 1.28979801197461 0.109323637730893 no 381 0.0985603991934075 464 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2055 5235184 200 µM 1.28727291033157 0.109781691043277 no 382 0.0989995910815789 552 2836034
SGTC_2122 5258151 111.688 µM 1.28642090198425 0.109936555704802 no 383 0.0991481037599434 546 2173356
SGTC_3236 9132701 49.47 µM 1.28620050232619 0.10997664199344 no 384 0.0991865479039462 543 24282524
SGTC_2403 6032726 181.2 µM 1.28563741027352 0.110079104797955 no 385 0.0992848171198135 548 2881040
SGTC_1484 3473-2379 286 µM 1.28556552111282 0.110092191006601 no 386 0.099297368133081 663 671917
SGTC_447 ml7 120 µM 1.28402657856186 0.110372597241705 no 387 0.0995663279235166 552 4216 Selective myosin light chain kinase inhibitor.
SGTC_2997 9067075 71.4286 µM 1.28098935260488 0.110927503223207 no 388 0.100098702981633 601 27209819
SGTC_1547 harmine 94.2 µM 1.28001116324021 0.111106644712118 no 389 0.100270604941362 629 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1634 st006576 41 µM 1.27925671250797 0.111244953092349 no 390 0.100403335334552 546 3915356
SGTC_3322 9139058 2.11 µM 1.27811719614537 0.111454086580112 no 391 0.100604053255816 558 4908926 YPR165W RHO1
SGTC_2762 leflunomide 42.06 µM 1.27562673768882 0.111912135275018 no 392 0.101043748874307 602 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1091 telmisartan 47.6 µM 1.27450938692358 0.112118076897931 no 393 0.101241474035522 563 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1886 st057356 49.9 µM 1.27372294341239 0.1122631905516 no 394 0.101380811163612 539 24207747
SGTC_2189 6047310 154.431 µM 1.27323546273888 0.112353207283866 no 395 0.101467250035278 538 711535
SGTC_2641 levomentholum 100 µM 1.27319130905442 0.11236136311849 no 396 0.101475081908209 491 16666
SGTC_2112 5488546 200 µM 1.27278634403681 0.112436185843543 no 397 0.101546934154948 572 600757
SGTC_3174 9107204 49.47 µM 1.27107331559013 0.11275308460148 no 398 0.101851283712407 558 3938802
SGTC_1401 3807-4679 7.6 µM 1.26995316533228 0.112960649429737 no 399 0.102050656757018 529 3291456
SGTC_987 1497-1013 404 µM 1.26980073116352 0.112988916683981 no 400 0.102077810110569 527 1676435
SGTC_1155 4088-0394 48.2 µM 1.26866188864472 0.113200262374378 no 401 0.102280840390876 567 2326248
SGTC_2964 9083345 53.42 µM 1.2643844706905 0.113996581659641 no 402 0.103046031998387 528 17741579
SGTC_1167 k781-0610 148 µM 1.26187363523559 0.114465874210434 no 403 0.103497130150636 624 4525169
SGTC_3311 9131146 2.8755 µM 1.26009863976404 0.114798461871212 no 404 0.103816890457938 589 4900406 YPR165W RHO1
SGTC_1219 1469-0211 33.1 µM 1.25795532308669 0.115200978837206 no 405 0.104203957094724 549 6822282
SGTC_1364 1653-0028 37.6 µM 1.25648516487411 0.115477655503992 no 406 0.10447006062636 590 5718652
SGTC_2507 purpurin 79.67 µM 1.25375519468792 0.115992674454823 no 407 0.104965499647018 597 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_152 4469-0003 551.229 µM 1.25359092686912 0.116023716113975 no 408 0.104995365372952 568 697280
SGTC_2241 6772625 37.8075 µM 1.25270668178104 0.116190913055272 no 409 0.105156236693743 550 2285411
SGTC_2286 7945697 125 µM 1.25199338378376 0.11632591111493 no 410 0.10528613741267 577 1245733
SGTC_2663 amphotericin b 100 µM 1.2493393262712 0.116829192626877 no 411 0.105770494951883 539 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2610 ononetin 44.17 µM 1.24855214654802 0.116978759669929 no 412 0.10591446212977 602 259632
SGTC_2351 9026858 72.31 µM 1.2470867646893 0.117257548929286 no 413 0.106182842686646 538 1409300
SGTC_1223 0764-0573 147 µM 1.24257336880163 0.118119179608106 no 414 0.107012544274427 620 1609797
SGTC_3144 9087057 49.47 µM 1.23805949530482 0.118985370337776 no 415 0.107847000620623 580 17249618
SGTC_854 0422-0053 192 µM 1.23714225414349 0.11916193146307 no 416 0.108017137612994 575 3596728
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.23651598162244 0.119282589797686 no 417 0.108133414459505 579 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_701 4424-0219 185 µM 1.23406115221363 0.119756371160938 no 418 0.108590058977227 665 2911779
SGTC_1520 flindersine 88 µM 1.23245824242572 0.120066447503195 no 419 0.108888977983911 613 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2049 5262831 67.185 µM 1.23108599887731 0.120332351598286 no 420 0.109145350758157 604 763417
SGTC_1721 st082152 9.2685 µM 1.22294475293123 0.121918438715745 no 421 0.110675281900777 561 5296051
SGTC_2063 5246145 200 µM 1.22167017467973 0.122168076947534 no 422 0.110916189716257 635 711240
SGTC_1236 0330-0013 258 µM 1.2178951013498 0.122909565692395 no 423 0.111631919000715 583 4617066
SGTC_783 0848-0141 92.7 µM 1.2148252157304 0.123514865594583 no 424 0.112216380681509 570 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.20932231545447 0.124605110539291 no 425 0.113269520418707 676 66535 A nucleotide analog.
SGTC_1151 3909-8316 15.3 µM 1.20826309045498 0.124815735870647 no 426 0.11347304043824 620 800431
SGTC_1055 3448-0672 86 µM 1.20775321424266 0.124917212654527 no 427 0.113571101228883 599 748378
SGTC_1901 st060216 58.6 µM 1.20522423304066 0.125421388428215 no 428 0.114058374882204 637 688792
SGTC_1014 4130-3005 69.3 µM 1.20346608516033 0.12577272731582 no 429 0.114398003964234 641 743608
SGTC_675 1309-0189 238 µM 1.20201157253305 0.126063907816411 no 430 0.114679522226517 617 4246530
SGTC_3317 9138495 8.753 µM 1.20139071201914 0.126188341584774 no 431 0.114799838645543 638 17020139
SGTC_874 0599-0792 117 µM 1.19944909217326 0.126578036267704 no 432 0.115176684202836 706 765305
SGTC_817 1391-0715 46 µM 1.19484127825798 0.127506204749692 no 433 0.116074524645143 599 1353946
SGTC_1689 st020265 53.493 µM 1.19476679795421 0.127521246350098 no 434 0.116089077946039 636 5758320 YPR016C TIF6
SGTC_1941 st076221 61.8 µM 1.19293835431323 0.127890894963289 no 435 0.116446758383094 681 2828568
SGTC_1066 ketoconazole 628 nM 1.19281831475089 0.127915188865395 no 436 0.116470267856913 680 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_235 0330-0087 5 mM 1.18805628850441 0.128881527038837 no 437 0.117405617037802 651 46494818 YHR062C RPP1
SGTC_295 k015-0027 31 µM 1.18734293901566 0.129026719005325 no 438 0.117546188748656 627 3887424
SGTC_762 1165-0429 115 µM 1.18719986611733 0.129055853073711 no 439 0.117574396845375 630 5967793
SGTC_2743 auranofin 4.32 µM 1.18687505301837 0.12912201200142 no 440 0.117638454430101 595 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_790 1575-0012 79.1 µM 1.18562001502676 0.129377862922235 no 441 0.117886197205229 652 378741 YLR208W SEC13
SGTC_1850 st056238 17 µM 1.18367703157366 0.129774650357894 no 442 0.1182704671941 690 5393177
SGTC_769 0302-0231 76 µM 1.1835369253188 0.129803294771935 no 443 0.118298210645464 738 571869 YER009W NTF2
SGTC_1292 0kpi-0043 232 µM 1.18345848428109 0.129819333780226 no 444 0.118313745330821 607 3333905
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.17708955097386 0.131126184401573 no 445 0.119579882609249 593 2374 Ca(2+)-ATPase inhibitor.
SGTC_2025 5147754 141 µM 1.17550639701865 0.131452439401863 no 446 0.119896089701937 620 315777 YLR208W SEC13
SGTC_70 0141-0289 43.283 µM 1.17395304503092 0.131773097094727 no 447 0.120206916859405 846 352408
SGTC_1502 4534-4282 27.7 µM 1.17223933030694 0.132127484046709 no 448 0.120550490965484 609 3278949
SGTC_1158 4092-0494 91.8 µM 1.17202286179088 0.132172295269768 no 449 0.120593938796391 669 1148199
SGTC_732 3970-1727 52.7 µM 1.16905201013412 0.132788351090136 no 450 0.121191338615052 633 1275699
SGTC_1426 4048-4480 71.7 µM 1.16747190922674 0.133116815788529 no 451 0.121509923033811 650 14224343
SGTC_1591 genipin 88.4 µM 1.16651238061939 0.133316551210907 no 452 0.121703672958084 612 442424 A DNA cross-linking agent.
SGTC_1125 tnp00248 1.32998 µM 1.16245225287475 0.134163988670441 no 453 0.122525904383295 780 24207736
SGTC_169 k015-0017 16.025 µM 1.16151376536739 0.134360396897718 no 454 0.122716514252121 593 1840002
SGTC_409 arachidonic acid 100 µM 1.1613759450569 0.134389256779485 no 455 0.122744523511008 657 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1312 1218-2183 165 µM 1.15918736852583 0.134848120116864 no 456 0.123189909545797 684 6744073
SGTC_2810 7959871 45.46 µM 1.15900301511615 0.13488682121594 no 457 0.123227478020338 701 2974535
SGTC_83 0170-0301 39.027 µM 1.15484992230871 0.13576069484208 no 458 0.124075944750318 554 3089716
SGTC_480 am 92016 50 µM 1.15471393937298 0.135789373120094 no 459 0.12410379467379 599 2129 K+ channel blocker.
SGTC_116 0155-0182 31.788 µM 1.15255882264751 0.13624443290283 no 460 0.124545756382769 788 771486
SGTC_54 0159-0055 9 µM 1.15098090698829 0.136578275845611 no 461 0.124870045236344 652 3319099
SGTC_1272 0839-0021 27 µM 1.15040903843031 0.136699405277635 no 462 0.124987719600318 683 5027250
SGTC_163 TUB2.036 7.546 µM 1.14800994446765 0.137208365828404 no 463 0.125482229289903 828 15992207 YJR013W GPI14
SGTC_2444 5485484 36.41 µM 1.14745560375839 0.137326151396795 no 464 0.125596685889333 696 6790631
SGTC_836 0330-0104 1.35 µM 1.1471273457617 0.137395931756127 no 465 0.125664496757439 670 46494820
SGTC_793 0488-0545 106 µM 1.14700057468916 0.137422886950062 no 466 0.125690691703246 675 292548
SGTC_768 0384-0033 77.3 µM 1.14643324778057 0.137543561282546 no 467 0.125807966201954 697 3965305 YMR134W ERG29
SGTC_317 4495-0002 170 µM 1.14375476748549 0.13811426924795 no 468 0.126362676657154 613 15991618
SGTC_1492 4158-0558 28.5 µM 1.13796968836483 0.139352408976225 no 469 0.127566569826511 655 3967268
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.13764513003331 0.139422094918372 no 470 0.127634346893723 774 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1740 st038286 13.222 µM 1.1362892547622 0.139713471337736 no 471 0.127917763174096 666 716786
SGTC_2862 9027634 71.43 µM 1.13375343931346 0.140259526412167 no 472 0.128448993324315 630 5012562
SGTC_2449 5812982 45.77 µM 1.13350470922644 0.140313165176755 no 473 0.128501182355862 630 776185
SGTC_3080 9117754 49.47 µM 1.13263916356015 0.140499929096185 no 474 0.128682907546652 737 9550191
SGTC_3197 9113331 49.47 µM 1.13218302468084 0.140598420760065 no 475 0.128778747663086 680 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_509 pifithrin 175 µM 1.13032961929992 0.140999098807815 no 476 0.129168679148878 703 4817 A p53 inhibitor.
SGTC_3332 9141069 11.198 µM 1.12998862787847 0.141072900232731 no 477 0.129240508197111 608 17332883
SGTC_1285 0929-0069 65.5 µM 1.12960618790564 0.141155703607924 no 478 0.12932110122025 678 1206237
SGTC_1736 st036774 51 µM 1.12752297168738 0.141607326411124 no 479 0.129760716837587 711 1272247
SGTC_3093 9117344 49.47 µM 1.1265738868869 0.141813403810954 no 480 0.12996134245038 646 24824913
SGTC_3117 9124945 49.47 µM 1.12441596310572 0.14228271529287 no 481 0.130418301569245 603 17592065
SGTC_329 k048-0121 21.3 µM 1.12411403232273 0.142348463776609 no 482 0.130482326552526 660 6832902
SGTC_633 0437-0093 97.7 µM 1.1206378068354 0.143106927683432 no 483 0.131221032620722 674 2831118
SGTC_1183 1254-0324 198 µM 1.1206108078645 0.143112829146795 no 484 0.13122678124631 699 5799357
SGTC_26 0302-0163 425.158 µM 1.12052495220712 0.143131596659042 no 485 0.131245062803788 694 3100915
SGTC_1243 0416-0003 5.65 µM 1.11525010012949 0.144287835974251 no 486 0.132371631129876 651 2141977
SGTC_3026 9090633 49.47 µM 1.11503804678131 0.144334449003734 no 487 0.132417059018365 695 25236842
SGTC_2072 5231554 129 µM 1.11503293291679 0.144335573245791 no 488 0.132418154686975 710 789545
SGTC_1550 gossypolone 36.6 µM 1.11445156868233 0.144463419981232 no 489 0.132542755333777 699 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3089 9117425 49.47 µM 1.10887701026932 0.145693184251349 no 490 0.133741621359722 630 9401657
SGTC_1899 st063254 59.6 µM 1.10809740134218 0.145865727602257 no 491 0.133909876572159 616 3093813
SGTC_1917 st066507 28.5 µM 1.10475317258628 0.146607431167995 no 492 0.134633278144584 733 3156428
SGTC_154 3389-1638 511.116 µM 1.10292813976671 0.147013263830709 no 493 0.135029186456618 613 5238686
SGTC_2840 9008771 71.43 µM 1.09938093864359 0.14780420840487 no 494 0.135800970731353 652 2992978
SGTC_2693 st077581 40.7 µM 1.09649047739534 0.148450818104582 no 495 0.13643209418984 799 25238761
SGTC_1695 st026914 34.495 µM 1.09620004560578 0.148515893486593 no 496 0.136495619838893 712 3289191
SGTC_2907 7721985 69.9 µM 1.09579141110224 0.148607486166638 no 497 0.13658503401795 678 3267881
SGTC_1719 st032227 49.2 µM 1.09370349421152 0.149076068064172 no 498 0.137042520645648 688 3125804
SGTC_202 3594-0513 34.79 µM 1.09326862973078 0.149173786810967 no 499 0.137137936049227 681 708429
SGTC_2402 5553605 200 µM 1.09221752298505 0.149410158475159 no 500 0.137368751088002 737 6758546
SGTC_261 5-fluorouridine 15.376 µM 1.0878349966048 0.150398389107924 no 501 0.138333978400007 725 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_120 rhodamine 6G 52.259 µM 1.08655456952607 0.150687937118763 no 502 0.13861685596955 851 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1194 1488-0194 225 µM 1.08637305968029 0.150729012673653 no 503 0.138656987790349 744 1391452
SGTC_1962 st076595 64.5 µM 1.08362250683131 0.151352373364701 no 504 0.139266103734622 717 279619
SGTC_3008 9078912 71.4286 µM 1.08317496167665 0.151453962941982 no 505 0.139365385556979 698 16648731
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.08269315535281 0.151563380229192 no 506 0.139472321564656 712 6312947
SGTC_3045 9092950 49.47 µM 1.08121293649152 0.151899863723343 no 507 0.139801202412533 765 44120432
SGTC_382 3229-0966 23.2 µM 1.08038573624294 0.152088118964411 no 508 0.139985222454075 761 5722370
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.07893553997578 0.152418530176108 no 509 0.140308232077766 742 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2287 7945887 168.79 µM 1.07823914774484 0.152577364647913 no 510 0.140463522831879 774 1245853
SGTC_771 0250-0039 27.3 µM 1.0768461994996 0.152895400359138 no 511 0.140774490887767 707 3005115
SGTC_1763 st044482 94.5 µM 1.07619210330449 0.153044894113477 no 512 0.140920675334172 751 88505
SGTC_2456 5770359 74.46 µM 1.07611522973403 0.153062469936798 no 513 0.140937862625599 760 3118787
SGTC_448 monastrol 171 µM 1.06902639953435 0.154688959909528 no 514 0.142528886952332 727 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_18 0111-0177 500 nM 1.06839083512694 0.15483534221673 no 515 0.142672124704106 838 721752
SGTC_508 roscovitine 141 µM 1.06778699851355 0.154974501763074 no 516 0.142808302064347 743 160355 A CDKinase inhibitor.
SGTC_319 1348-1596 45.5 µM 1.06716336473751 0.155118310420341 no 517 0.1429490362828 777 5380505
SGTC_3179 9107801 49.47 µM 1.06458878611992 0.155712935304435 no 518 0.143531028314471 725 4818259
SGTC_2240 6690706 185.951 µM 1.06426369524947 0.155788125063344 no 519 0.143604629755229 638 805876
SGTC_441 propafenone 146 µM 1.06270773737137 0.15614833157023 no 520 0.143957255464019 685 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_825 1988-2224 89.6 µM 1.06220312469739 0.156265267887463 no 521 0.144071740811987 749 1180859
SGTC_416 estradiol valerate 100 µM 1.06048220917154 0.156664497635574 no 522 0.144462639753407 732 13791 A steroid.
SGTC_37 0566-0070 1.56 µM 1.05836007899878 0.157157727507471 no 523 0.14494565613584 799 1626686
SGTC_1666 st014829 29 µM 1.05487492019814 0.157969968547947 no 524 0.14574126695414 774 3858230
SGTC_411 enrofloxacin 100 µM 1.05168240515456 0.158716421352772 no 525 0.146472643064791 763 71188 A bacterial gyrase inhibitor.
SGTC_1081 sertraline 6 µM 1.05012073062958 0.159082402669387 no 526 0.146831304319451 774 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_809 3998-0021 90 µM 1.04879396669148 0.159393766289287 no 527 0.147136477444292 726 715485
SGTC_122 0236-0016 402.397 µM 1.04822099047696 0.159528355049093 no 528 0.147268400878082 814 6808838
SGTC_1473 k844-0725 134 µM 1.04601286639671 0.160047725980409 no 529 0.147777546035298 827 54682906
SGTC_2960 9079389 5.97 µM 1.04581968069091 0.160093217559937 no 530 0.147822146441819 771 16457355
SGTC_2659 sanguinarine 24.21 µM 1.04574520892498 0.160110756509633 no 531 0.147839341999542 734 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1992 st073643 23.3 µM 1.04533671436678 0.160206983977781 no 532 0.147933687361146 734 3161292
SGTC_1021 4476-0760 85.3 µM 1.04503027542148 0.1602791954156 no 533 0.148004488545875 724 746768
SGTC_680 0417-1641 114 µM 1.04188966970298 0.161020495969942 no 534 0.148731417036487 710 2835990
SGTC_1631 benzylvanillin 81.9 µM 1.04028956952626 0.16139903858553 no 535 0.149102694325965 761 75506
SGTC_340 k038-0059 454 µM 1.03804367802234 0.161931337002708 no 536 0.149624860394045 780 23733424
SGTC_2780 5215298 71.43 µM 1.03689472951382 0.162204090806715 no 537 0.149892460241789 815 2834131
SGTC_2717 st081029 62.2815 µM 1.03673193461737 0.162242761564707 no 538 0.149930402353744 741 5292846
SGTC_2624 nerol 100 µM 1.03597860192566 0.162421788480394 no 539 0.150106062703465 750 637566 A natural product oil.
SGTC_2731 amoxapine 43.43 µM 1.03589434916611 0.162441818848709 no 540 0.15012571709103 672 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_322 k048-0136 19.3 µM 1.03491574769408 0.162674590695801 no 541 0.150354129805912 719 6823282
SGTC_3234 9132280 49.47 µM 1.03210074009586 0.163345382426828 no 542 0.151012463596977 761 17612295
SGTC_1133 3473-0247 50 µM 1.03182106348803 0.163412124913039 no 543 0.15107797497116 745 711311
SGTC_2054 5233173 129 µM 1.03047944163261 0.163732538019599 no 544 0.151392499023362 811 6889
SGTC_3201 9113999 49.47 µM 1.02808799533669 0.164304686305474 no 545 0.151954218515523 741 16649224
SGTC_73 0327-0325 16.231 µM 1.02746703269416 0.164453462008294 no 546 0.152100300657782 853 53298
SGTC_3273 9137859 49.47 µM 1.02737778667597 0.164474851530574 no 547 0.152121303544024 776 2377234
SGTC_1522 st012842 45.6 µM 1.02438728099552 0.165192626116314 no 548 0.152826193553491 697 3491067 YOR116C RPO31
SGTC_2442 5158906 48.48 µM 1.02416165662708 0.165246862109311 no 549 0.152879463051805 784 1893835
SGTC_2127 5253358 187.912 µM 1.0240118510629 0.165282879006431 no 550 0.152914838670366 682 20612
SGTC_2284 7945075 39.21 µM 1.02383916510079 0.165324403209741 no 551 0.152955624081239 866 1245402
SGTC_3175 9106517 49.47 µM 1.02277336507817 0.165580835711991 no 552 0.153207507058582 765 41468073
SGTC_2323 6148992 148.28 µM 1.01884553008288 0.166528096112521 no 553 0.154138153265474 700 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1265 0819-1001 68.8 µM 1.0178557851566 0.16676733967923 no 554 0.154373248267662 750 3106768
SGTC_510 ag-490 170 µM 1.01742176143407 0.166872322867589 no 555 0.154476417051328 851 5328779
SGTC_44 0929-0055 61.211 µM 1.01669580858768 0.16704801416677 no 556 0.154649080142228 723 1379590
SGTC_274 sirtinol 40.1 µM 1.01660522628567 0.167069944787499 no 557 0.1546706334906 783 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.01525559261798 0.167396920595006 no 558 0.154992003343038 734 6708760
SGTC_1474 0330-0125 5.35 µM 1.01502466493247 0.167452908742444 no 559 0.155047035150642 794 X1474
SGTC_1211 1056-0033 32.3 µM 1.01341541692011 0.167843403988876 no 560 0.155430889276551 821 6741922
SGTC_2221 6807166 181.081 µM 1.0127674281508 0.168000808409323 no 561 0.155585631044902 721 674925
SGTC_3245 9134821 49.47 µM 1.0102872223974 0.168604158210021 no 562 0.156178850560544 800 17014901
SGTC_1711 st032263 62.8 µM 1.0101066658305 0.16864813581366 no 563 0.156222094480853 768 3958979
SGTC_936 3005-4620 401 µM 1.00990677327285 0.168696831623507 no 564 0.156269978637487 852 777207
SGTC_543 3844-1095 191 µM 1.00736852719449 0.169315959327268 no 565 0.156878854931807 833 4230703
SGTC_869 0564-0080 44.1 µM 1.00549518781061 0.169773837585538 no 566 0.15732923274295 786 6843321
SGTC_736 0958-0254 92.6 µM 1.00438305532863 0.170046038297082 no 567 0.157597007121393 829 6812352
SGTC_1031 k035-0009 16 µM 1.00288778741582 0.170412454182712 no 568 0.157957502851978 860 5180959
SGTC_3319 9138450 16.7555 µM 1.00142586242922 0.170771187890033 no 569 0.158310482939676 756 2029690
SGTC_2479 5617353 43.85 µM 1.00125484736112 0.170813183886813 no 570 0.158351808114897 800 2731746
SGTC_90 0870-0863 4.608 µM 1.00090521447988 0.170899063445249 no 571 0.158436317664911 830 1738164
SGTC_345 1362-0200 395 µM 1.00012791484963 0.171090088812816 no 572 0.158624304262204 756 1419823
SGTC_1672 st016598 6.51 µM 0.999055881281922 0.171353770519506 no 573 0.158883810863218 777 4665860 YNL267W PIK1
SGTC_248 streptozotocin 5.23457 mM 0.998615101950876 0.171462261707144 no 574 0.158990590758696 849 5300 DNA alkylating agent.
SGTC_2727 riluzole 51.77 µM 0.99805947005331 0.171599084656582 no 575 0.159125260957635 737 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_69 0096-0274 206.684 µM 0.996221980195113 0.172052058521512 no 576 0.159571150993322 871 6741392
SGTC_2571 chrysanthemic acid 100 µM 0.994484494310879 0.172481081052227 no 577 0.159993525292334 747 2743 An insecticide.
SGTC_696 1560-0013 611 µM 0.990514958899513 0.173463801968793 no 578 0.160961240604788 813 1650269
SGTC_1170 0310-0127 64.8 µM 0.990443063933193 0.17348163349292 no 579 0.16097880270852 837 774975
SGTC_2274 7947094 46.08 µM 0.98591213906906 0.174607755012053 no 580 0.162088114753139 851 2971028
SGTC_2084 5306078 60.6385 µM 0.984378494481298 0.174989978028427 no 581 0.162464723966894 791 679340
SGTC_2310 7668677 200 µM 0.983596926281915 0.175184968641759 no 582 0.162656868520523 790 2197143
SGTC_1834 st055981 52.8 µM 0.978499807393738 0.176460008228058 no 583 0.16391359327234 844 471719 YDL150W RPC53
SGTC_1745 st081495 74 µM 0.974464976223909 0.177473469261298 no 584 0.16491286050487 877 13842402 YBL026W LSM2
SGTC_967 1306-0166 352 µM 0.970126633236565 0.178567256237435 no 585 0.165991687497615 833 4437607
SGTC_121 0557-0495 61.343 µM 0.969361653796382 0.178760562943932 no 586 0.16618238884371 1045 3104427
SGTC_2363 9053361 176 µM 0.967089418405524 0.179335522585035 no 587 0.166749667413923 835 6469797 YMR079W SEC14
SGTC_824 1304-0008 100 µM 0.966600679238424 0.179459343468992 no 588 0.166871847459284 840 768245
SGTC_27 0485-0001 32.618 µM 0.966122040008495 0.179580657632885 no 589 0.166991558574558 764 2054479
SGTC_2716 st080858 38.6235 µM 0.965540733462525 0.179728062772733 no 590 0.167137021983145 882 5296050
SGTC_891 0929-0073 133 µM 0.96506181328089 0.179849562327945 no 591 0.16725692606917 848 5603632
SGTC_764 1951-2361 146 µM 0.96442500784529 0.180011196435157 no 592 0.167416444698197 803 5438930
SGTC_2373 9071805 200 µM 0.963767513557799 0.180178177464162 no 593 0.167581248673862 851 10149009
SGTC_772 k072-0172 35.3 µM 0.96256830096618 0.180482986674413 no 594 0.167882105863888 770 5861980
SGTC_1722 st034304 3.6505 µM 0.962448599111258 0.180513429573066 no 595 0.167912155613165 828 4036148 YLR033W RSC58
SGTC_1832 st054113 55 µM 0.962350358078739 0.180538416903762 no 596 0.167936820460943 815 1251267
SGTC_3131 9127911 49.47 µM 0.960517182368107 0.181005077865995 no 597 0.168397493759469 801 45595681
SGTC_637 1181-0519 7.26 µM 0.959667124989509 0.18122172833592 no 598 0.168611386963549 916 6252091 YGR060W ERG25
SGTC_632 0781-2353 4.65 µM 0.959237516457343 0.181331282571422 no 599 0.168719552358676 848 6811515 YHR007C ERG11
SGTC_3048 9093155 49.47 µM 0.95911994482284 0.181361271675366 no 600 0.168749161920722 788 25236002
SGTC_2703 st077852 53.4 µM 0.957489504262934 0.181777469717553 no 601 0.169160120744755 808 6281836
SGTC_2881 9058953 51.95 µM 0.956041760889712 0.182147531551237 no 602 0.169525568215646 910 17122249
SGTC_835 0312-0010 67.2 µM 0.955310774061645 0.182334559977471 no 603 0.16971028030541 809 1626196
SGTC_401 neomycin 50 µM 0.954892566720534 0.18244161538502 no 604 0.169816014590938 821 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1257 0669-0121 16 µM 0.954808062297113 0.182463252139157 no 605 0.169837384755852 932 4307855
SGTC_1038 k292-0204 154 µM 0.95421481648831 0.182615193614442 no 606 0.169987458117473 782 4454212
SGTC_2920 7982904 15.77 µM 0.952937423153169 0.182942626347106 no 607 0.170310888721918 795 6456808
SGTC_3318 9139014 38.6185 µM 0.95157431405499 0.183292434295633 no 608 0.170656456677361 819 16643984
SGTC_582 0987-0078 156 µM 0.950431000600254 0.183586158582176 no 609 0.170946649120311 960 1625765
SGTC_818 4072-2707 53.5 µM 0.946738076430951 0.184536895928976 no 610 0.171886131419046 840 882871
SGTC_1324 1418-0026 34.4 µM 0.944911696534651 0.185008224100635 no 611 0.172351979783066 875 1372513
SGTC_1939 st074455 53.6 µM 0.942598565656772 0.185606239016645 no 612 0.172943136889094 873 1644229
SGTC_1415 3966-0071 78.1 µM 0.942370302083272 0.185665317068149 no 613 0.173001543202947 861 2893185
SGTC_2555 cholic acid 100 µM 0.942210575520888 0.185706663646149 no 614 0.173042420270051 860 6708657 Influences liver metabolism.
SGTC_1994 st072947 40.9 µM 0.942083217987897 0.185739635318616 no 615 0.173075017894979 863 5286565 YDL195W SEC31
SGTC_3160 9100216 49.47 µM 0.93896906710691 0.186546989518716 no 616 0.173873313140949 877 17191039
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.937580929262397 0.186907568162657 no 617 0.174229907868084 866 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1442 4112-3290 3 µM 0.93463789701811 0.187673466881025 no 618 0.174987470873891 898 704353
SGTC_966 1300-0360 30.2 µM 0.931627335054354 0.188458942559149 no 619 0.175764575672846 833 70588
SGTC_2294 7971431 200 µM 0.930409510624927 0.188777256182356 no 620 0.176079548098693 781 5741572
SGTC_2906 7926292 26.41 µM 0.929482584341523 0.189019757105883 no 621 0.176319523320866 872 2966319
SGTC_1076 itraconazole 331 nM 0.92918648820183 0.189097261709005 no 622 0.17639622428849 912 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2237 6667747 47.222 µM 0.925540504093319 0.190053219362971 no 623 0.177342412456978 831 729940 YDL015C TSC13
SGTC_1500 4488-1866 171 µM 0.924515056768923 0.190322620444872 no 624 0.177609107934429 951 2900003
SGTC_2381 9035592 200 µM 0.923906311558105 0.190482658248946 no 625 0.177767548347095 809 4749657
SGTC_7 0192-1582 4.227 µM 0.923192655532795 0.190670382063753 no 626 0.177953407794396 967 252616
SGTC_2022 5136654 200 µM 0.922798222572002 0.190774184479201 no 627 0.178056183640651 852 1713771
SGTC_1854 st056233 32.9 µM 0.921771473954002 0.191044555173202 no 628 0.178323894950112 858 5393174
SGTC_1679 SEC14.276 6.7 µM 0.921207355754755 0.191193202732285 no 629 0.178471089311037 925 1005053 YMR079W SEC14
SGTC_413 propylparaben 100 µM 0.919467430407291 0.191652126955083 no 630 0.178925566842413 870 7175 A pharmaceutical preservative.
SGTC_304 1310-0298 97 µM 0.917711068758015 0.192116070053494 no 631 0.179385075620694 893 1550234
SGTC_404 fumagillin 50 µM 0.917146182760107 0.192265430665934 no 632 0.179533021682515 901 12015870 A methionine aminopeptidase binder.
SGTC_499 genistein 192 µM 0.915804257584491 0.19262053163989 no 633 0.179884785015604 889 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2729 fluphenazine 10.66 µM 0.915640644663432 0.19266385437876 no 634 0.179927703004666 917 3372 An atypical antipsychotic.
SGTC_1909 st060837 51.5 µM 0.915548671348212 0.19268821042362 no 635 0.179951831732596 841 678937
SGTC_2495 cafestol 54.53 µM 0.915451439194479 0.192713961141189 no 636 0.179977342299319 835 16667697 An anti-infammatory.
SGTC_3150 9097574 49.47 µM 0.915449348491878 0.192714514860668 no 637 0.179977890856879 888 17217476
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.915311971614989 0.192750901053124 no 638 0.18001393803794 917 23665772 A membrane-active detergent.
SGTC_3216 9129716 49.47 µM 0.914667316688871 0.192921703009297 no 639 0.180183153633437 819 8056934
SGTC_3056 9094900 49.47 µM 0.913826042958331 0.193144738292588 no 640 0.180404129844925 885 25236784
SGTC_2711 st079103 59.1 µM 0.9138082058435 0.193149468903926 no 641 0.180408816935238 887 54693780
SGTC_1567 st069303 68.4 µM 0.913665117972929 0.193187420039105 no 642 0.180446419153466 891 5581319
SGTC_1963 st076565 50.3 µM 0.911819532509946 0.193677331773256 no 643 0.180931863183145 879 4914280
SGTC_856 0433-0016 11.3 µM 0.911783076204782 0.193687016744252 no 644 0.180941460514559 911 3911780
SGTC_1112 tnp00069 1.16933 µM 0.910978819459758 0.193900750456496 no 645 0.181153266861418 948 145826
SGTC_3011 9081274 71.4286 µM 0.908348612200248 0.194600739275472 no 646 0.181847033263266 928 6625322
SGTC_488 nitrendipine 139 µM 0.906955530839429 0.194972108348628 no 647 0.182215156840707 932 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_988 1497-1057 103 µM 0.905461868969247 0.195370768612174 no 648 0.182610375966996 928 3533044
SGTC_2344 7990960 76.95 µM 0.905308882976961 0.195411628707069 no 649 0.182650885871126 858 140813
SGTC_2133 5320837 200 µM 0.90472759120819 0.19556692970357 no 650 0.182804860104719 837 2841355
SGTC_1229 0139-0193 12.2 µM 0.903849407496121 0.195801692016803 no 651 0.183037629542659 954 3090752
SGTC_2899 9053889 58.44 µM 0.903349239439032 0.19593547691064 no 652 0.183170285601154 912 6470052
SGTC_3041 9091929 49.47 µM 0.902446597777586 0.19617705571294 no 653 0.183409838623086 949 25236887
SGTC_1768 st044301 37.178 µM 0.900797888541145 0.196618774544543 no 654 0.183847895207738 936 3931349
SGTC_2031 5180455 200 µM 0.896844147361023 0.197680505048165 no 655 0.184901043440794 884 29949
SGTC_1997 st073024 93.8 µM 0.896131222585123 0.197872320651077 no 656 0.185091341635785 926 686268
SGTC_97 0535-0701 19.132 µM 0.895209797185057 0.198120400788137 no 657 0.185337474243784 847 2832013 YGL099W LSG1
SGTC_3246 9135460 32.98 µM 0.892683201623816 0.198801612022166 no 658 0.186013424365619 853 41446951
SGTC_3252 9135871 49.47 µM 0.892398810360854 0.198878376845157 no 659 0.186089604270995 912 17682838
SGTC_13 0199-0087 65 µM 0.890953371471862 0.199268815635487 no 660 0.186477092940057 977 4589825
SGTC_460 trequinsin 123 µM 0.889134562639293 0.199760763633426 no 661 0.18696538288784 974 5537 A vasodilator.
SGTC_2273 7815444 169.05 µM 0.888687740972922 0.199881730815136 no 662 0.187085460644546 919 2824616
SGTC_213 1246-0773 967 nM 0.88826807241665 0.199995386997225 no 663 0.18719828477266 932 6251622
SGTC_971 1315-0384 26.7 µM 0.886403589045805 0.200500802851646 no 664 0.187700042946646 907 6769120
SGTC_638 3970-0837 4.09 µM 0.88399441798751 0.201155004945384 no 665 0.188349613063004 901 4118451 YLR208W SEC13
SGTC_1232 0279-0259 161 µM 0.879864119425209 0.202279547201132 no 666 0.189466462129351 933 1560000
SGTC_89 0302-0250 142.109 µM 0.879324429311419 0.202426764055369 no 667 0.18961269692682 1027 4203518 YLR208W SEC13
SGTC_2694 st077685 81.9 µM 0.878426536283493 0.202671833536056 no 668 0.189856144433423 907 2838096
SGTC_2486 5283202 22.39 µM 0.874718371782531 0.203685810656546 no 669 0.190863580656848 870 1377751
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.874671672668684 0.203698599527097 no 670 0.190876288774378 954 641818 YHR062C RPP1
SGTC_2591 skatole 100 µM 0.872823943848587 0.204204996781448 no 671 0.191379523300417 931 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_255 tunicamycin 200.472 nM 0.871810559688469 0.204483047674022 no 672 0.191655866459984 933 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1267 0828-0272 9.49 µM 0.871787641100004 0.204489338647942 no 673 0.191662119032213 972 745334
SGTC_1362 1611-0397 101 µM 0.870731954623916 0.204779241191907 no 674 0.191950263264251 950 27816
SGTC_2386 9075165 157.42 µM 0.867423167149525 0.205689451154185 no 675 0.192855096386211 942 16452277
SGTC_3101 9120531 49.47 µM 0.864595569451743 0.206469190717232 no 676 0.193630402572654 957 24824904
SGTC_1376 2910-0861 41.3 µM 0.863962345470338 0.206644048531082 no 677 0.193804287997609 979 1112859
SGTC_1775 st081588 35.1725 µM 0.863738010065547 0.206706017309059 no 678 0.193865914078758 993 1426443 YGL099W LSG1
SGTC_2778 tioconazole 65.09 nM 0.861489569554693 0.207327717718328 no 679 0.194484231706585 910 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1617 st002906 78 µM 0.86117409953772 0.207415034462086 no 680 0.194571081389803 972 5150859
SGTC_200 k038-0079 37.545 µM 0.860966074078936 0.207472624268504 no 681 0.194628364229053 941 3436683
SGTC_3115 9123671 49.47 µM 0.860843891310584 0.207506453774013 no 682 0.194662013816536 1022 3286988
SGTC_136 0097-0015 404.482 µM 0.857587294268701 0.208409328998915 no 683 0.195560196706002 1059 4861337
SGTC_719 2810-4230 27.3 µM 0.857185997826792 0.208520746550616 no 684 0.195671049810884 957 721079
SGTC_3301 9125354 19.7965 µM 0.856657617265203 0.20866750180006 no 685 0.195817066475478 891 41905162
SGTC_3155 9099265 49.47 µM 0.856538768965506 0.208700519748804 no 686 0.195849919017408 884 25236499
SGTC_904 1141-0088 396 µM 0.855464430613826 0.208999127737421 no 687 0.196147043845997 942 1378119
SGTC_965 1291-5240 308 µM 0.852774295603949 0.209747942901578 no 688 0.196892240465906 953 2834598
SGTC_2888 9058547 12.99 µM 0.850460698432304 0.210393206395573 no 689 0.197534500997856 875 16476514
SGTC_3288 9119690 36.221 µM 0.849811630095227 0.210574441016182 no 690 0.19771491130125 903 17595618 YKL019W RAM2
SGTC_779 1360-0071 233 µM 0.849537529160706 0.210651003726513 no 691 0.197791128293483 1029 7566
SGTC_2529 gangaleoidin 93.61 µM 0.848743883826107 0.210872779252748 no 692 0.198011910818947 979 4565183
SGTC_1372 2752-0194 270 µM 0.846509849671567 0.211497790395073 no 693 0.198634190738947 908 823334
SGTC_2198 6589944 200 µM 0.846215047015189 0.21158034766482 no 694 0.198716394654865 899 5290268
SGTC_1132 3456-3614 2.5 µM 0.846068789919351 0.211621312866701 no 695 0.198757185162443 1063 3125502
SGTC_344 k064-0035 6.43 µM 0.844844045394573 0.211964534177101 no 696 0.199098959511738 939 5088750
SGTC_15 0266-0086 27.098 µM 0.84364323969393 0.212301362787545 no 697 0.199434397066512 1062 1712902 YIL048W NEO1
SGTC_3068 9116768 49.47 µM 0.843213919215329 0.212421863987427 no 698 0.199554407568637 952 41904888
SGTC_337 1315-0038 354 µM 0.843045335348595 0.212469192846541 no 699 0.199601544699602 959 1626437
SGTC_1868 st057644 42.7 µM 0.842441514843539 0.212638762192017 no 700 0.199770431758138 1038 688665
SGTC_1406 3909-7906 11.9 µM 0.841004965198036 0.213042502224493 no 701 0.200172576417561 993 X1406
SGTC_3126 9127922 49.47 µM 0.84061889417956 0.213151083080598 no 702 0.200280735210541 967 45595682
SGTC_970 1315-0089 19.5 µM 0.840296747056137 0.213241710307755 no 703 0.200371012428668 959 6811083 YLR033W RSC58
SGTC_2030 5175110 200 µM 0.840050146349141 0.213311099810953 no 704 0.20044013533792 987 2831986
SGTC_2779 methotrexate 400 µM 0.839806110135996 0.213379780664935 no 705 0.200508553510106 1072 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1839 st053978 48 µM 0.836600172257732 0.214283247030168 no 706 0.201408674369695 996 3788398
SGTC_1253 0550-0034 176 µM 0.836244791775104 0.214383533736916 no 707 0.201508602294941 938 5969915
SGTC_2861 9024595 19.48 µM 0.834931951693114 0.214754247642951 no 708 0.201878011709167 945 16482810
SGTC_2566 crystal violet carbinol 226 nM 0.833826965688282 0.215066557130396 no 709 0.202189248765041 878 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2662 daunorubicin 22.37 µM 0.831473234827901 0.215732686022354 no 710 0.202853171148102 953 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2152 5568786 200 µM 0.83030502428512 0.21606374467316 no 711 0.203183174061453 978 5399883
SGTC_2033 5192550 145 µM 0.830164608568733 0.216103556820015 no 712 0.203222861072906 990 182073
SGTC_3097 9117246 49.47 µM 0.82720663620744 0.216943219344036 no 713 0.204059975457801 1049 16423892
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.82716147373093 0.216956053953738 no 714 0.204072772464766 984 5355888
SGTC_1907 st060210 83.7 µM 0.826432470181448 0.217163288334106 no 715 0.204279405293564 1064 688793
SGTC_2482 5981709 142.65 µM 0.822975270152865 0.218147624921202 no 716 0.205261028339363 994 877755
SGTC_1252 0493-0875 34.8 µM 0.822891957698342 0.218171377392426 no 717 0.205284718259627 966 3960963
SGTC_1635 st007035 42.4 µM 0.821731572968281 0.218502359250383 no 718 0.205614842814376 1058 3716403
SGTC_1193 1488-0126 41.5 µM 0.819668560209983 0.219091515264236 no 719 0.206202538813934 1069 1384710
SGTC_62 0180-0423 3.232 µM 0.819622102855448 0.219104793082378 no 720 0.206215784699979 1010 30102 YGL099W LSG1
SGTC_3313 9133968 57.047 µM 0.818329052684268 0.219474540959321 no 721 0.206584660545541 1041 1494643
SGTC_2537 larixol 68.93 µM 0.818204567025217 0.219510156556928 no 722 0.206620193895873 1042 6708759
SGTC_1296 1068-0102 11.9 µM 0.815018526431204 0.220422818355883 no 723 0.20753085274587 1002 767053
SGTC_2354 9060492 162 µM 0.814930596760531 0.220448037176618 no 724 0.207556019076038 1053 6471895
SGTC_3059 1327-0034 3 µM 0.814719939929006 0.220508461698164 no 725 0.207616318453267 981 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_872 0588-0139 234 µM 0.814452972019683 0.220585052046967 no 726 0.207692751441034 1060 2047100
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.813960757870459 0.220726303174371 no 727 0.207833716061241 1049 4174840
SGTC_1375 2910-0797 186 µM 0.8124748085196 0.221153041485072 no 728 0.20825961794276 1006 742508
SGTC_2463 5473429 200 µM 0.811471862412722 0.221441336444668 no 729 0.208547372578667 991 5399405
SGTC_950 1165-0508 94.1 µM 0.811381677583589 0.221467270427958 no 730 0.208573258933427 969 6148369
SGTC_2757 clomiphene 4.22 µM 0.810853450536746 0.221619204803484 no 731 0.208724917514263 1104 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_192 3455-0609 60.9 µM 0.810427201998558 0.221741850432537 no 732 0.208847344546099 1020 3769639
SGTC_286 k060-0067 22.9 µM 0.810412478153766 0.221746087656422 no 733 0.208851574282111 991 5985051
SGTC_3222 9128301 49.47 µM 0.809467913471432 0.222018010866249 no 734 0.209123025938234 1044 4911358
SGTC_469 w7 172 µM 0.808766832142248 0.222219962621838 no 735 0.209324638913859 1048 45115570 A P450 inhibitor.
SGTC_125 0133-0007 11.75 µM 0.808096405565899 0.222413182057802 no 736 0.209517543329414 1133 26541
SGTC_3123 9126162 49.47 µM 0.807368495922806 0.22262307678581 no 737 0.209727105934775 1087 25239884
SGTC_2034 5197015 53.07 µM 0.80736218047533 0.222624898356258 no 738 0.20972892466883 1006 780676
SGTC_1270 0831-1170 17.3 µM 0.805450600842609 0.223176647438722 no 739 0.210279850940609 1052 6764716
SGTC_1017 4239-0030 168 µM 0.803534929110024 0.223730357790384 no 740 0.210832808207075 1012 1149593
SGTC_811 0416-0114 265 µM 0.802714295586146 0.223967794409767 no 741 0.211069944136218 1008 6612453
SGTC_486 niguldipine 82 µM 0.799719352769639 0.2248355448377 no 742 0.211936708841729 994 1236 A calcium channel blocker.
SGTC_2478 5763493 32.33 µM 0.799604086577674 0.224868979947293 no 743 0.211970109519754 1034 1365576 YLR208W SEC13
SGTC_681 1642-0006 26.6 µM 0.799483221313684 0.224904042199445 no 744 0.212005135947104 1055 4446530
SGTC_985 1493-0307 8.71 µM 0.797871493429693 0.225371890409009 no 745 0.212472533772422 1024 3278274
SGTC_1693 xanthone 101.9 µM 0.79664899128971 0.225727122367798 no 746 0.212827458051704 1061 7020 An insecticide.
SGTC_1860 st056228 74.6 µM 0.794950865515835 0.226221085147282 no 747 0.213321042070688 1041 688679
SGTC_2400 5203494 178.7 µM 0.794831186271963 0.226255921311506 no 748 0.213355853675101 1001 6777674
SGTC_2902 5787006 60.46 µM 0.794070153360305 0.226477513222941 no 749 0.213577295990692 1013 591003
SGTC_884 0851-0618 334 µM 0.793106632025743 0.226758239912668 no 750 0.213857849596386 1067 9642473
SGTC_2842 9000675 19.48 µM 0.792881448035962 0.226823876671912 no 751 0.213923448533458 1031 2989072
SGTC_1739 st037196 92.5 µM 0.79273583122261 0.226866326850583 no 752 0.213965874784642 1084 612214
SGTC_391 gliotoxin 8.33 µM 0.792110182613362 0.227048766766812 no 753 0.214148216637233 1066 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2738 aclarubicin 5.55 µM 0.792012083882462 0.227077379979473 no 754 0.214176815171781 960 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_446 go6976 132 µM 0.791698926229355 0.227168734687161 no 755 0.214268124288999 1052 3501 A protein kinase C inhibitor.
SGTC_573 3702-0553 84.7 µM 0.791437596468607 0.227244985957334 no 756 0.214344338989994 1031 1222756
SGTC_167 3672-0051 66.205 µM 0.787757374275504 0.228320338466864 no 757 0.215419319239403 1038 3237971
SGTC_3257 9139206 32.98 µM 0.785926247925194 0.228856453106194 no 758 0.215955348067939 1035 4910041
SGTC_1176 0848-0131 83.3 µM 0.785705450952222 0.228921145438508 no 759 0.216020034520844 1132 6769040
SGTC_550 4123-0385 25.7 µM 0.785389465103818 0.229013745451974 no 760 0.216112627793531 1050 5731123
SGTC_1199 1638-0010 4.46 µM 0.784233376173127 0.229352717669112 no 761 0.216451592143108 1023 3111136
SGTC_1317 1273-0028 910 nM 0.783812464382583 0.229476201338234 no 762 0.216575079500591 1052 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2823 7987624 58.44 µM 0.781654257423562 0.230109943430544 no 763 0.217208895492589 1044 2239440
SGTC_309 k408-0051 1.48 µM 0.779923887231814 0.230618760786113 no 764 0.217717838621165 1080 3640463
SGTC_2858 9025781 8.96 µM 0.778004324745056 0.231183945131034 no 765 0.218283231830487 1136 4894980 YPL153C RAD53
SGTC_2953 9074162 66.49 µM 0.77722517057537 0.231413574887014 no 766 0.218512967191543 1011 16451992
SGTC_561 1550-0330 72.9 µM 0.775488904809545 0.231925738640591 no 767 0.21902540956688 1051 6812934
SGTC_956 1185-0240 191 µM 0.770523144640675 0.233394017531974 no 768 0.220494815640278 1064 1416193
SGTC_3265 9137266 49.47 µM 0.770153458548383 0.233503532407072 no 769 0.220604434031259 1059 17224265
SGTC_751 0833-0568 350 µM 0.768944774697048 0.233861788712054 no 770 0.220963047758648 1089 6954252
SGTC_3085 9117376 49.47 µM 0.768393170466009 0.234025386470105 no 771 0.221126818295621 1080 16480349
SGTC_603 3794-0023 45.9 µM 0.768164406110063 0.234093253228388 no 772 0.221194758486894 1081 3802260
SGTC_2204 7233102 200 µM 0.767622078340805 0.234254187337372 no 773 0.221355870846129 1031 2172480
SGTC_1154 4088-0362 150 µM 0.767512832294636 0.234286613177549 no 774 0.221388333301754 1132 6618304
SGTC_1638 st008370 60.6 µM 0.767445449403333 0.234306614653726 no 775 0.221408357480854 1104 24207134
SGTC_3043 9092303 49.47 µM 0.767343153735325 0.234336981205975 no 776 0.221438758671866 1053 25236084
SGTC_2099 5377090 177.372 µM 0.766039059059543 0.234724293588365 no 777 0.221826530911205 1048 2243829
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.762994080110578 0.235630020100759 no 778 0.222733463188386 1132 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_501 nsc-95397 161 µM 0.762040838009102 0.235913956891534 no 779 0.223017815478073 1065 262093
SGTC_2383 9036125 200 µM 0.760543813636096 0.236360247396018 no 780 0.223464795138143 1063 79580
SGTC_993 3909-8757 62.7 µM 0.760211598337952 0.236459349869293 no 781 0.223564056618511 1010 4288324 YLR208W SEC13
SGTC_2852 9023854 51.95 µM 0.759316235016066 0.236726557734945 no 782 0.223831704015209 1118 19798528
SGTC_728 3030-5151 22.5 µM 0.758632072867652 0.236930847636335 no 783 0.224036340574448 1071 3125388
SGTC_3349 9149703 23.001 µM 0.757668281525163 0.237218798790898 no 784 0.224324795958569 1108 4910494
SGTC_2466 5983409 37.09 µM 0.756684201266827 0.237513009884083 no 785 0.224619541076656 1044 2879657
SGTC_1563 conessine 56.1 µM 0.753950245138019 0.238331432604999 no 786 0.225439549202548 1206 441082 An anti-amoebic, histamine inhibitor.
SGTC_1888 azatryptophan 97.5 µM 0.752520093542018 0.238760169798845 no 787 0.225869175411263 1030 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1659 st012954 42.1 µM 0.752355446048189 0.238809555625191 no 788 0.22591866621925 1075 24207262
SGTC_270 tamoxifen 5.46 µM 0.75181805694614 0.238970783742512 no 789 0.226080240767888 1178 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2996 9066192 71.4286 µM 0.750576839206493 0.239343402744859 no 790 0.226453682079239 1129 6472854
SGTC_3125 9127534 49.47 µM 0.750531254101364 0.239357093632316 no 791 0.226467403755613 1005 1639235
SGTC_1979 st071809 45.3 µM 0.74942165260502 0.239690479759702 no 792 0.226801552194348 1118 4976333
SGTC_3200 9114385 49.47 µM 0.748914206155589 0.239843029356178 no 793 0.226954458653429 1103 17018030 YLR208W SEC13
SGTC_1012 4112-3522 18 µM 0.748677177185765 0.239914303636338 no 794 0.227025901397098 1128 3112398
SGTC_882 0843-0131 351 µM 0.746913033617108 0.240445141913424 no 795 0.227558028976334 1155 5425421
SGTC_2684 capsaicin 100 µM 0.746615363125199 0.240534775259283 no 796 0.227647886039794 1105 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_890 0929-0006 47.2 µM 0.745894651712919 0.240751868323825 no 797 0.227865528143151 1115 1378169
SGTC_2864 9034755 47.6 µM 0.745302978632025 0.240930172064028 no 798 0.228044290430184 1146 4930451
SGTC_305 1682-2595 20.8 µM 0.744725716921994 0.241104202064969 no 799 0.228218774597417 1121 226033
SGTC_115 0527-0192 112.043 µM 0.74335345848608 0.241518177937356 no 800 0.228633857029757 1140 4233931
SGTC_40 0327-0103 19.753 µM 0.742936349353175 0.241644085732275 no 801 0.228760108685972 1063 409036
SGTC_2069 5228469 200 µM 0.742133613563475 0.24188649832722 no 802 0.229003192910478 1095 2835210
SGTC_2669 eugenol 100 µM 0.741336522837956 0.242127336696675 no 803 0.22924471103143 1096 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2003 4023581 200 µM 0.741142070717156 0.242186109493459 no 804 0.229303651597753 1115 16641307
SGTC_1392 3455-1037 33.9 µM 0.738117623464881 0.243101237957366 no 805 0.230221487635046 1126 981132
SGTC_2239 6685329 187.64 µM 0.735850392969724 0.243788474361262 no 806 0.230910874757247 1100 805680
SGTC_721 1187-1332 279 µM 0.732243437179478 0.244883962155439 no 807 0.232009998126704 1059 25730
SGTC_1481 3346-2004 36 µM 0.731014861941576 0.245257703249072 no 808 0.232385037593464 1169 2770522
SGTC_1611 st001856 99.4 µM 0.730949804011595 0.245277502867516 no 809 0.232404906817119 1125 647478
SGTC_2027 5150920 200 µM 0.730241494003632 0.245493124310938 no 810 0.232621291620122 1142 786715
SGTC_468 gf-109203x 121 µM 0.730012257718329 0.245562929486851 no 811 0.232691346022953 1059 2396 A protein kinase C inhibitor.
SGTC_807 1315-0151 48 µM 0.729895935369395 0.245598355103342 no 812 0.232726898512466 1178 4011080
SGTC_939 1165-0479 45.3 µM 0.72929950344313 0.245780039739403 no 813 0.232909237980165 1115 1377347
SGTC_377 3970-0964 33.1 µM 0.729076918172525 0.245847861977691 no 814 0.232977306443287 1164 16481235
SGTC_1988 st071872 53.4 µM 0.728736760392548 0.245951528230023 no 815 0.233081350917363 1149 16414116
SGTC_253 dyclonine 31.25 µM 0.728583339362926 0.245998292392424 no 816 0.233128286435343 1202 3180 An oral anasthetic.
SGTC_140 0062-0056 502.533 µM 0.728569199805762 0.246002602501555 no 817 0.233132612360897 1155 3758964
SGTC_2639 lactacystin 53 µM 0.728441766571873 0.24604144933288 no 818 0.233171601920922 1150 3870 A proteasome inhibitor.
SGTC_2995 9067767 71.4286 µM 0.728224954677623 0.246107549975991 no 819 0.233237946154949 1115 11673567
SGTC_628 1636-0253 16 µM 0.727988129564503 0.246179763043021 no 820 0.233310426385801 1141 4456143
SGTC_927 2425-1185 123 µM 0.726593324778504 0.246605299435943 no 821 0.233737559314755 1153 730375
SGTC_2184 6075246 200 µM 0.726342164578569 0.246681966912221 no 822 0.23381451846431 1138 2267320
SGTC_778 3456-2434 196 µM 0.72632035540857 0.246688624835281 no 823 0.233821201774757 1202 5539063
SGTC_671 0560-0003 407 µM 0.725323238407552 0.246993128361129 no 824 0.234126876309178 1091 3238678
SGTC_3108 9121785 49.47 µM 0.725123672154809 0.24705409683608 no 825 0.234188081573926 1130 17140271
SGTC_2986 9022445 71.43 µM 0.724305519935814 0.24730413051585 no 826 0.234439094449965 1128 6459286
SGTC_855 0428-0020 25 µM 0.724198632431525 0.247336806156867 no 827 0.234471899020499 1119 6812414
SGTC_828 2074-0507 139 µM 0.723821428842812 0.247452136196768 no 828 0.234587685901265 1176 X828
SGTC_698 k064-0052 127 µM 0.722180064482172 0.247954317953575 no 829 0.235091889158815 1180 5088751
SGTC_3188 9110789 49.47 µM 0.721517065290106 0.248157319216244 no 830 0.235295722469285 1178 849217
SGTC_2855 9016525 58.44 µM 0.720878136493175 0.248353034295785 no 831 0.235492247830587 1197 43811474
SGTC_1942 st076330 65.2 µM 0.720792577603211 0.248379248727558 no 832 0.235518571396255 1200 24208414
SGTC_2962 9082311 13.18 µM 0.719935657709512 0.248641882189254 no 833 0.235782306093286 1156 16459453
SGTC_1397 3532-0190 20.1 µM 0.71892476255803 0.2489518968947 no 834 0.236093639080722 1084 5322280
SGTC_3076 9116187 49.47 µM 0.718428047452837 0.24910430156751 no 835 0.236246699112196 1113 27241210
SGTC_1511 0906-3109 28.5 µM 0.718249176390681 0.249159195854897 no 836 0.236301830626968 1222 2882180
SGTC_3014 9081533 49.47 µM 0.715476931982333 0.250010800387548 no 837 0.237157194977149 1167 21367265
SGTC_554 4483-2211 187 µM 0.714563987066878 0.250291585212067 no 838 0.23743925217123 1135 747107
SGTC_885 0865-0106 16.8 µM 0.714354191645602 0.250356133391386 no 839 0.237504095137425 1170 2793380
SGTC_1335 1486-0900 202 µM 0.713806471718737 0.250524693066612 no 840 0.237673428642742 1187 X1335
SGTC_1064 honokiol 6.76 µM 0.713111010547937 0.250738806423094 no 841 0.237888533356408 1168 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_617 3770-0098 35 µM 0.712957144799535 0.250786190540561 no 842 0.237936138134055 1134 5962639
SGTC_1002 4049-0206 172 µM 0.71260132566469 0.250895785883037 no 843 0.238046245605138 1204 4662749
SGTC_1258 0671-0043 57.1 µM 0.70991056165991 0.251725384283462 no 844 0.238879800247657 1175 4298767
SGTC_3289 9119912 71.43 µM 0.709365601230288 0.25189357906997 no 845 0.239048814246209 1191 17014829
SGTC_614 0462-0418 107 µM 0.70913238692622 0.251965575682324 no 846 0.239121163286535 1065 5188303
SGTC_1878 temozolomide 1 mM 0.70796541262436 0.252326000506554 no 847 0.239483368260576 1143 5394 DNA alkylating agent.
SGTC_2798 7813637 45.45 µM 0.707946087588323 0.252331971410528 no 848 0.239489368877316 1153 956368
SGTC_285 1486-1325 46 µM 0.707092419190709 0.252595805739385 no 849 0.239754523338842 1173 22310230
SGTC_2150 5556613 200 µM 0.705666166410593 0.253036926713154 no 850 0.240197883046663 1183 743190
SGTC_2417 cerulenin 830 nM 0.70553682097294 0.253076951568275 no 851 0.240238112981619 1203 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3277 9138724 49.47 µM 0.704948655605629 0.253258996379758 no 852 0.240421094644481 1071 15943418
SGTC_794 k038-0031 316 µM 0.704525204794666 0.253390102516032 no 853 0.240552879637147 1219 6624242
SGTC_1371 2421-0008 32.7 µM 0.704374627459448 0.253436731905528 no 854 0.240599751306672 1147 2827552
SGTC_2504 purpurogallin 52.29 µM 0.703677980520596 0.253652521733468 no 855 0.240816668064766 1115 5281571 An antioxidant.
SGTC_2443 5493264 126.67 µM 0.702481762589869 0.254023281132171 no 856 0.241189385623638 1175 5340055
SGTC_537 1334-0398 209 µM 0.70055942760746 0.254619690505765 no 857 0.241789002959819 1186 5846986
SGTC_2782 7736369 71.43 µM 0.697772618510278 0.255485605738128 no 858 0.242659702767553 1242 2950836 YOL077C BRX1
SGTC_1122 capsaicin 818.572 nM 0.697685525973727 0.25551269183719 no 859 0.242686940949293 1205 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2708 st078559 56 µM 0.697626728881247 0.25553097879737 no 860 0.242705330669732 1120 17250902
SGTC_2820 7989630 71.43 µM 0.697477484003912 0.255577399726182 no 861 0.242752012752513 1094 2984098
SGTC_2567 aureobasidin a 60 nM 0.697360836160403 0.255613684783368 no 862 0.242788502241112 1227 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_327 1273-0057 3.96 µM 0.696893298830859 0.255759146264686 no 863 0.242934785896629 1145 3108138
SGTC_925 2064-1272 59.6 µM 0.695915775398029 0.256063415578666 no 864 0.243240788640989 1176 6815817
SGTC_1514 1189-1591 158 µM 0.694152200616135 0.256612832773642 no 865 0.243793382573051 1207 767698 YMR146C TIF34
SGTC_649 1123-0311 367 µM 0.688341166730458 0.258427514305585 no 866 0.245618981746954 1189 693629 YIL048W NEO1
SGTC_2947 9072639 7.68 µM 0.685988947997969 0.259163955620729 no 867 0.246360038891365 1226 16488146
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.685519238278597 0.259311143913178 no 868 0.246508162483807 1150 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1276 0871-0068 94.2 µM 0.68414932664129 0.259740666147073 no 869 0.246940438342606 1179 3414906
SGTC_1385 3091-4834 14.1 µM 0.683206605738067 0.26003646008464 no 870 0.247238149557254 1179 4072814
SGTC_1341 1486-1360 280 µM 0.681097434373158 0.26069887518026 no 871 0.247904920191271 1218 3976547
SGTC_2623 humulene 100 µM 0.680839621950928 0.260779904337913 no 872 0.247986487999082 1166 6187145 An anti-inflammatory.
SGTC_1445 4239-0156 97.7 µM 0.680221397863922 0.260974261860894 no 873 0.248182142736648 1269 4008346
SGTC_1624 st003710 6.25 µM 0.678595203099608 0.26148586100342 no 874 0.248697191536038 1235 24207033
SGTC_2352 9027995 87.8 µM 0.678525892908783 0.261507677351251 no 875 0.248719156117164 1189 2997347
SGTC_905 2-aminofluorene 215 µM 0.678465436830513 0.261526707506866 no 876 0.248738315650297 1254 1539 An established DNA mutagen. YPR165W RHO1
SGTC_349 k015-0014 24 µM 0.677368584124691 0.26187209443104 no 877 0.249086062886956 1207 2196908
SGTC_738 1315-0003 72.4 µM 0.676984808576374 0.261992996375045 no 878 0.249207796504717 1225 6251474
SGTC_1358 1509-0022 2.48 µM 0.676323558586928 0.262201379021289 no 879 0.249417619224369 1243 3258434
SGTC_1050 3232-1156 69.3 µM 0.6761294922852 0.262262552111134 no 880 0.249479216655746 1189 700529
SGTC_164 4100-3994 89.624 µM 0.676112047892635 0.262268051246633 no 881 0.249484753972666 1251 4615967
SGTC_272 doxorubicin 8.13 µM 0.672763821341043 0.263324632041319 no 882 0.25054877884448 1249 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_692 k241-0027 77.8 µM 0.67231601131365 0.263466109518627 no 883 0.250691269381293 1284 3600480
SGTC_1738 st035555 74 µM 0.670074605136181 0.264174823884731 no 884 0.251405116262013 1249 5331140
SGTC_2236 dapsone 200 µM 0.669834524577743 0.26425079293487 no 885 0.251481641181534 1251 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3038 9091290 49.47 µM 0.669659411662897 0.264306211192084 no 886 0.251537465632289 1261 25236843
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.669515990405051 0.264351604348736 no 887 0.251583191939409 1194 4620898
SGTC_2831 7999036 19.48 µM 0.665042981950932 0.265769311017092 no 888 0.253011500989992 1252 2988270
SGTC_1974 st069448 26.9 µM 0.664111655721818 0.266064976117968 no 889 0.253309425330504 1212 6323587 YNR016C ACC1
SGTC_1332 1480-0653 17.5 µM 0.66327595803728 0.266330424070905 no 890 0.253576915720967 1219 5749438
SGTC_177 1327-0068 8.361 µM 0.661982493839742 0.266741539378075 no 891 0.253991220549898 1257 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3308 9128332 17.569 µM 0.660956995068774 0.267067712223184 no 892 0.254319946593536 1269 17332805 YDL196W YDL196W
SGTC_2101 5377231 179.231 µM 0.660217682597105 0.267302984762178 no 893 0.254557073222964 1256 2844213
SGTC_1212 0520-0165 585 µM 0.659894823230579 0.267405761588917 no 894 0.254660663260923 1400 5403258
SGTC_2234 tolnaftate 200 µM 0.659603406518323 0.267498546290074 no 895 0.254754183816813 1235 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3118 9124250 49.47 µM 0.659120066926284 0.267652473453425 no 896 0.25490933530877 1188 1504786
SGTC_2777 climbazole 1.536 µM 0.658099987809746 0.267977480304579 no 897 0.255236941852546 1228 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2594 a-mangostin 100 µM 0.657398389200432 0.268201131537576 no 898 0.255462393546063 1276 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_132 0417-1715 25.805 µM 0.656953450630434 0.268343014935391 no 899 0.255605424003256 1287 6769098
SGTC_1662 st014054 52 µM 0.656857222865417 0.268373705309511 no 900 0.255636362989814 1255 2838777
SGTC_1462 k081-0014 26.5 µM 0.656542761478274 0.268474010268696 no 901 0.255737481714437 1070 3270634
SGTC_2890 9046729 58.44 µM 0.65583388706513 0.268700191781639 no 902 0.25596550511891 1188 903329
SGTC_412 gemfibrozil 100 µM 0.655369421925863 0.268848441195052 no 903 0.256114966972808 1240 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1424 4048-1941 275 µM 0.655234339677718 0.268891564871982 no 904 0.256158444101704 1309 X1424
SGTC_1244 0416-0015 52.5 µM 0.655002207318212 0.268965678952604 no 905 0.25623316644941 1273 96201
SGTC_93 0109-0045 59.227 µM 0.654932029752217 0.268988086920088 no 906 0.256255758524628 1317 88733
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.654412575244944 0.269153979882352 no 907 0.256423017403501 1226 756377
SGTC_2802 7925815 54.55 µM 0.654271430232974 0.269199064812548 no 908 0.25646847443666 1264 1262923
SGTC_191 3914-0123 66.505 µM 0.649823725411598 0.270621700719461 no 909 0.257903045887041 1193 3144412
SGTC_341 1486-1430 230 µM 0.649446008578616 0.2707426893961 no 910 0.25802506693193 1232 2054753 YPL210C SRP72
SGTC_3343 9148379 18.9835 µM 0.646707561655986 0.2716206640967 no 911 0.258910614122159 1301 1955036
SGTC_419 nsc-638432 893 µM 0.646342891098571 0.27173768815792 no 912 0.259028658235087 1272 368090
SGTC_1409 3909-8004 61.9 µM 0.646076247429681 0.271823270926455 no 913 0.259114988588414 1270 2119279
SGTC_3017 9080681 49.47 µM 0.645862579151993 0.271891860229678 no 914 0.259184178006447 1271 16451914
SGTC_1953 st076800 12.1 µM 0.645369885522996 0.272050051813083 no 915 0.259343756965345 1234 297591
SGTC_913 3487-1245 167 µM 0.645168758009828 0.272114641971675 no 916 0.259408914915056 1228 4016153
SGTC_2845 9003024 42.97 µM 0.644464779097893 0.272340778025004 no 917 0.259637044887998 1335 2990173
SGTC_348 k064-0012 10.7 µM 0.64288805346747 0.272847601148468 no 918 0.260148370877757 1216 5066323
SGTC_875 0709-0210 25.7 µM 0.642680780339651 0.272914261855714 no 919 0.260215627329061 1297 6251364
SGTC_1216 1165-0504 9.65 µM 0.6411570760039 0.273404545208134 no 920 0.260710317261289 1278 6304004
SGTC_3020 9089140 49.47 µM 0.640110545336622 0.273741540517263 no 921 0.26105036684665 1287 17217859
SGTC_1700 st030840 7.9285 µM 0.637953325155039 0.274436838623757 no 922 0.261752031903954 1308 5499307
SGTC_2839 9003951 25.97 µM 0.635716686813212 0.275158653273177 no 923 0.262480549083779 1285 2990634
SGTC_2202 7226349 200 µM 0.635625106026963 0.275188228410291 no 924 0.262510400856177 1245 844334
SGTC_360 0957-0399 1.01 µM 0.634948279019578 0.275406851719231 no 925 0.262731073990528 1300 6752301 YPR165W RHO1
SGTC_2327 6189656 200 µM 0.631814693334393 0.276420150096333 no 926 0.263753985624019 1347 5349088
SGTC_1742 st038235 28.8875 µM 0.631093601917549 0.276653585827567 no 927 0.263989662148181 1290 564103 YBR002C RER2
SGTC_2427 5545055 42.75 µM 0.630906732342748 0.276714096045812 no 928 0.264050754810929 1328 5372858
SGTC_3339 9145883 14.936 µM 0.630586537119923 0.276817793501535 no 929 0.264155451938926 1240 2030670
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.629371772120926 0.277211376614994 no 930 0.26455284683339 1311 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1100 amiodarone 5.07 µM 0.627919697569805 0.277682206780252 no 931 0.265028273298018 1333 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1718 roemerine 11.9335 µM 0.627605296428864 0.277784201684737 no 932 0.265131269104896 1239 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3187 9109394 49.47 µM 0.626280242188377 0.278214263561031 no 933 0.265565571684062 1238 17098090
SGTC_1368 1852-0141 284 µM 0.626015079171511 0.278300364293952 no 934 0.265652525385826 1286 2838987
SGTC_1925 st057770 10.1 µM 0.625931801200404 0.278327408054058 no 935 0.265679837330884 1225 5989122
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.625567150171736 0.278445840225762 no 936 0.265799445491368 1291 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3356 9151811 4.48 µM 0.624321670647404 0.278850534896222 no 937 0.266208177442181 1281 1859254 YPR165W RHO1
SGTC_2634 4'-methoxyflavone 100 µM 0.624112022271158 0.278918684246618 no 938 0.266277009518268 1306 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2470 5664817 21.68 µM 0.622481970342845 0.279448833332162 no 939 0.266812497784285 1334 2859561
SGTC_3294 9122953 26.2835 µM 0.621976364749513 0.279613373088537 no 940 0.266978704750688 1292 16459826
SGTC_3293 9120939 62.045 µM 0.621283127114314 0.279839050551449 no 941 0.267206676686388 1328 934087
SGTC_126 0417-1624 672.48 µM 0.620877002253047 0.279971301984282 no 942 0.26734027690422 1378 41912 YDL195W SEC31
SGTC_688 0527-0193 473 µM 0.620757439288308 0.280010242515943 no 943 0.267379615164521 1320 4007154
SGTC_3235 9132602 49.47 µM 0.619980546941365 0.280263332976861 no 944 0.26763529714249 1335 4912240
SGTC_2519 cryptotanshinone 88.04 µM 0.619836006323578 0.280310432613628 no 945 0.267682880301225 1293 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1990 st072050 59.8 µM 0.618378230860314 0.280785673783506 no 946 0.268163022111098 1300 17233948
SGTC_2093 5331342 194.4 µM 0.617941556332354 0.280928107384481 no 947 0.268306932206223 1313 33839
SGTC_1403 3909-7815 62.9 µM 0.617189610555348 0.281173457326302 no 948 0.268554833843498 1299 6615483
SGTC_1938 st074717 56.4 µM 0.614739573011952 0.281973589233108 no 949 0.269363360581563 1239 17250979
SGTC_1946 st076057 65.1 µM 0.613122502551901 0.282502291333447 no 950 0.269897671103929 1230 953009
SGTC_2908 7930301 100 µM 0.612689385403618 0.282643980119788 no 951 0.270040871189996 1261 2223178
SGTC_2032 5185112 25.99 µM 0.611600169953521 0.283000454022939 no 952 0.270401162812838 1249 5718189
SGTC_1539 benzyladenosine 56 µM 0.610846403611988 0.283247269827278 no 953 0.270650634873331 1299 92208 A nucleotide analog.
SGTC_3082 9117008 49.47 µM 0.609934930891779 0.283545863384624 no 954 0.270952456054586 1329 41448529
SGTC_2218 6965428 192.983 µM 0.609199838903839 0.283786785385016 no 955 0.271195993545952 1318 675684
SGTC_518 1021-0119 62.6 µM 0.60823999825966 0.284101514877798 no 956 0.271514154929038 1266 1097762
SGTC_1062 mesoridazine 14.2 µM 0.607889463232017 0.284216496093283 no 957 0.271630394199473 1337 4078 A neuroleptic.
SGTC_2419 paclitaxel 166.5 µM 0.60567194206172 0.284944394358328 no 958 0.272366309615206 1258 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2932 9016711 44.54 µM 0.603416091613863 0.285685785237314 no 959 0.273115959980092 1348 7117328
SGTC_1969 st069479 40.1 µM 0.603293825985757 0.28572599434588 no 960 0.27315661973664 1361 3895485
SGTC_816 0325-0417 81.3 µM 0.602742714777456 0.285907269945416 no 961 0.273339930442667 1309 68101
SGTC_2334 9017922 200 µM 0.602216877030626 0.286080283366013 no 962 0.27351489146267 1390 3163164
SGTC_2800 7887935 81.82 µM 0.601091249553013 0.286450809335359 no 963 0.273889605640988 1355 2961002
SGTC_24 0417-1663 219 µM 0.60091639850525 0.286508385976225 no 964 0.273947835200638 1318 4329390
SGTC_2732 terfenadine 20 µM 0.60067477999381 0.286587957486889 no 965 0.274028309983465 1345 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1049 3226-0134 66 µM 0.600486509122484 0.286649967441965 no 966 0.274091024606414 1353 5702385
SGTC_1872 amphotericin b 148 nM 0.600464408201022 0.286657247143274 no 967 0.27409838707573 1322 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_734 2023-0417 80 µM 0.600368256680468 0.286688918985623 no 968 0.274130419122612 1347 3935732
SGTC_246 cycloheximide 667 µM 0.59953020461108 0.286965039484189 no 969 0.274409687191872 1251 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_831 k061-1017 217 µM 0.598015800827764 0.287464322892392 no 970 0.274914695029506 1381 1240153
SGTC_1009 4106-0057 9.87 µM 0.595862218720846 0.288175043511426 no 971 0.275633637314068 1347 2928005
SGTC_597 k018-0003 82.8 µM 0.593742530394963 0.288875387045917 no 972 0.276342166147105 1446 6786234
SGTC_335 4077-0256 27.6 µM 0.593296208239372 0.289022953601461 no 973 0.276491467960995 1354 3121989
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.591839670533337 0.289504772115854 no 974 0.276978977809464 1354 616764
SGTC_2375 9072683 200 µM 0.59155679193067 0.289598391275918 no 975 0.277073707351548 1422 16798029
SGTC_1382 3002-2117 298 µM 0.589416868381325 0.290307062671745 no 976 0.277790831787944 1414 1497314
SGTC_1129 3453-1384 223 µM 0.588029901626042 0.290766813216849 no 977 0.278256111266238 1433 1084452
SGTC_3334 9142812 21.919 µM 0.586763425000705 0.291186920929621 no 978 0.278681302069126 1402 45283678
SGTC_1419 3993-2473 62.6 µM 0.586444710108708 0.29129268765913 no 979 0.278788353164317 1396 704026
SGTC_1402 3909-7673 35.9 µM 0.584292858152635 0.292007256553277 no 980 0.279511648162473 1347 5328014
SGTC_3260 9137109 49.47 µM 0.58345962008733 0.292284170262092 no 981 0.279791966285091 1290 17478346
SGTC_1047 2043-3044 82 µM 0.582400043049353 0.292636480517548 no 982 0.280148626278429 1324 669592
SGTC_2785 7756463 72.73 µM 0.582371694243803 0.292645909228314 no 983 0.280158171681777 1319 2201551
SGTC_2408 sulbentine 18.36 µM 0.581630279236019 0.292892551286676 no 984 0.280407871485285 1452 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2064 5220758 200 µM 0.580079097318223 0.293408885458849 no 985 0.280930639481031 1392 788518
SGTC_2884 9058502 51.95 µM 0.577739834138042 0.294188340792024 no 986 0.281719890571389 1358 6471554
SGTC_1117 retinoic acid 1.10837 µM 0.577485130081158 0.294273267304781 no 987 0.281805890432839 1454 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2709 st078560 56 µM 0.576634752958312 0.294556892331445 no 988 0.282093108655251 1439 17250903
SGTC_611 3453-1652 23.7 µM 0.576312522465174 0.29466439833609 no 989 0.282201980085071 1397 1560575
SGTC_3276 9139060 49.47 µM 0.575321254931396 0.294995229094661 no 990 0.282537024584164 1417 4870619
SGTC_655 k060-0012 42 µM 0.574443429452727 0.295288341902858 no 991 0.282833885696457 1341 5994525
SGTC_2946 9065502 71.43 µM 0.573777611430987 0.295510753108053 no 992 0.283059150452089 1246 16489101
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.572203308590308 0.296036942602143 no 993 0.283592123137637 1348 688667
SGTC_2418 pentamidine 31.67 µM 0.572162707504105 0.296050518654485 no 994 0.283605874798261 1333 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2859 9028643 45.46 µM 0.571827029692893 0.296162772398874 no 995 0.283719581711744 1336 17151580
SGTC_2900 5328528 85.29 µM 0.57179376572084 0.29617389724012 no 996 0.283730850680183 1350 795359
SGTC_2781 5567276 71.43 µM 0.571260141093048 0.296352389477694 no 997 0.283911658116492 1415 2853274
SGTC_1812 st052057 4.327 µM 0.570806255429329 0.296504248612626 no 998 0.284065491074976 1344 3645418
SGTC_1215 3852-0577 11.2 µM 0.570699423857498 0.296539997049076 no 999 0.284101704704846 1483 2884876
SGTC_2186 6124449 200 µM 0.569046323275522 0.297093416133611 no 1000 0.284662351880915 1386 3834182 YLR033W RSC58
SGTC_640 3381-0960 37.1 µM 0.568696663973668 0.297210534305216 no 1001 0.284781006075203 1468 1745025
SGTC_743 1275-0778 158 µM 0.568290010751564 0.297346769092321 no 1002 0.284919030396779 1439 2849257 YMR203W TOM40
SGTC_2126 5251174 33.877 µM 0.567523922482929 0.29760349735179 no 1003 0.285179139113582 1485 790722
SGTC_1280 0880-0253 10.1 µM 0.566674879650455 0.297888143130312 no 1004 0.285467545404001 1376 6836607
SGTC_880 0833-0487 87.2 µM 0.566445729477628 0.297964988118316 no 1005 0.28554540784876 1347 76075
SGTC_2196 6573537 42.6665 µM 0.564809958832255 0.298513802354708 no 1006 0.286101516269713 1460 2903087
SGTC_2105 5350118 200 µM 0.56423665973057 0.298706257594202 no 1007 0.28629654087803 1375 2133313
SGTC_3084 9116877 49.47 µM 0.562324063243638 0.29934871960379 no 1008 0.286947623138914 1330 27241325
SGTC_2108 5365811 200 µM 0.56175776343882 0.299539066066402 no 1009 0.287140536289753 1469 780283
SGTC_3049 9092223 49.47 µM 0.55892157965878 0.300493197268914 no 1010 0.288107620573049 1386 8623917
SGTC_158 k038-0087 26.446 µM 0.558742835546382 0.300553375200194 no 1011 0.288168620336794 1410 X158
SGTC_1476 4112-3294 3.34 µM 0.558731705473021 0.300557122551364 no 1012 0.288172418883526 1461 704369
SGTC_60 0986-0278 202 µM 0.558206861734556 0.300733854570922 no 1013 0.288351567920069 1214 3110598
SGTC_2622 2-methoxyxanthone 59.94 µM 0.55681683832448 0.301202147233104 no 1014 0.28882628905516 1486 71034 A hepatoprotective.
SGTC_1876 myriocin 605 nM 0.556446809986335 0.301326863463087 no 1015 0.288952723197832 1491 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2556 citropten 84.59 µM 0.553159162990343 0.302435968177348 no 1016 0.290077213747403 1377 2775 A potential DNA crosslinker.
SGTC_2553 4-methylesculetin 85.09 µM 0.54984796469752 0.303554864602771 no 1017 0.291211828540878 1383 5319502
SGTC_2886 9058944 51.95 µM 0.548800118500592 0.30390932994941 no 1018 0.291571314485352 1329 4949929
SGTC_2005 4024620 188 µM 0.54771922977279 0.304275166207581 no 1019 0.291942353039017 1398 236743
SGTC_3096 9117468 49.47 µM 0.547637207040637 0.304302935524273 no 1020 0.291970518098418 1339 41316311
SGTC_1945 st075991 56.6 µM 0.547485429745047 0.3043543236673 no 1021 0.292022638895913 1345 1084980
SGTC_1299 1079-1439 3.74 µM 0.547376124048858 0.304391334340923 no 1022 0.292060177496318 1368 323161
SGTC_2891 9063876 19.48 µM 0.546928573578775 0.304542894858538 no 1023 0.292213902132969 1408 6472478
SGTC_1423 4048-0112 5.59 µM 0.545958927366257 0.304871375351673 no 1024 0.292547085279611 1461 X1423
SGTC_2879 9041815 71.43 µM 0.54508724236993 0.305166804491578 no 1025 0.29284675826829 1378 4942971
SGTC_3007 9078383 71.4286 µM 0.544300538576228 0.305433541065594 no 1026 0.29311733819576 1419 6496995
SGTC_22 0964-0034 14.468 µM 0.544278431594243 0.305441038061732 no 1027 0.293124943374516 1370 138402
SGTC_629 3448-6466 76.7 µM 0.543934651664357 0.305557632398071 no 1028 0.29324322130676 1410 573744
SGTC_1306 1185-0270 9.02 µM 0.543683962147966 0.305642667183458 no 1029 0.293329485307552 1439 1548076
SGTC_2773 thioridazine 9.09 µM 0.543213133621248 0.305802402243504 no 1030 0.293491532444828 1421 5452 An antipsychotic.
SGTC_1687 st020778 55.3625 µM 0.541469620795411 0.306394234572482 no 1031 0.294091965717142 1442 4259299
SGTC_1015 4130-4525 82 µM 0.539911871922932 0.306923437266216 no 1032 0.294628905086149 1379 1363237
SGTC_822 1487-0950 154 µM 0.538570180682041 0.307379563030783 no 1033 0.295091733870087 1442 1958375
SGTC_1326 1431-2094 10.8 µM 0.538276633972371 0.307479397900732 no 1034 0.295193040145199 1396 616278
SGTC_2046 4110841 106 µM 0.537279334936083 0.307818684572324 no 1035 0.295537338818888 1429 44119630 YMR134W ERG29
SGTC_2288 7946289 167.31 µM 0.536388461705323 0.308121903622617 no 1036 0.295845052045226 1541 1246052
SGTC_2991 9074669 71.4286 µM 0.536375435024262 0.308126338377112 no 1037 0.295849552634387 1513 17333109
SGTC_3340 9146634 11.102 µM 0.535097183143038 0.308561637812361 no 1038 0.296291328838139 1428 4907387
SGTC_2368 9071271 200 µM 0.534764002622943 0.30867514428248 no 1039 0.296406528929275 1387 27209959
SGTC_976 1348-1067 47.6 µM 0.534460312829689 0.308778619908763 no 1040 0.296511550225203 1448 5310671 YGL099W LSG1
SGTC_2753 fluvastatin 17.09 µM 0.533719006747713 0.309031267421738 no 1041 0.296767978545927 1469 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1202 1988-0068 29.6 µM 0.532790497356824 0.309347843916112 no 1042 0.297089306292812 1374 2850480
SGTC_574 1315-0397 40 µM 0.532521168779962 0.309439698345668 no 1043 0.29718254215694 1425 6794277
SGTC_507 nimesulide 162 µM 0.531961224843298 0.30963070516258 no 1044 0.297376425717827 1499 4495 A COX2 inhibitor.
SGTC_1464 k208-0027 110 µM 0.531361292171737 0.309835409912291 no 1045 0.29758421968451 1520 X1464
SGTC_2658 polymyxin b sulfate 77.05 µM 0.530565283652964 0.310107109304032 no 1046 0.297860029162177 1415 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2092 5303694 80.6725 µM 0.529906410298967 0.310332079185948 no 1047 0.298088410727905 1406 1963699
SGTC_3272 9137413 49.47 µM 0.528536658634886 0.310800002965758 no 1048 0.298563455202102 1357 17614870
SGTC_300 r073-0011 5.04 µM 0.528080029020038 0.310956061260839 no 1049 0.298721895713261 1468 2735780
SGTC_2837 9008476 45.46 µM 0.52765053626866 0.311102876262145 no 1050 0.298870955197199 1467 2992805
SGTC_1437 4092-1038 11.6 µM 0.527475909034961 0.31116257829484 no 1051 0.298931570876736 1404 3977136
SGTC_2707 st078556 66.6 µM 0.525979909961841 0.311674237996266 no 1052 0.29945108281629 1477 17250899
SGTC_1610 st001799 48.1 µM 0.525454165317036 0.311854138954846 no 1053 0.29963375402905 1397 621897
SGTC_1342 1486-1464 234 µM 0.525413059814482 0.311868206458196 no 1054 0.299648038360314 1443 3253938
SGTC_1818 st052136 56.3 µM 0.523549865588568 0.312506133837991 no 1055 0.300295829661969 1374 674169
SGTC_232 clozapine 119 µM 0.522918300235166 0.312722499225154 no 1056 0.300515554478082 1451 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2533 agelasine 13.65 µM 0.522840310726998 0.31274922181012 no 1057 0.300542692462609 1584 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2439 5492030 7.2 µM 0.522471172613858 0.312875717874777 no 1058 0.30067115634769 1456 5722370
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.521191105006423 0.313314541427974 no 1059 0.301116824990354 1378 88881 An O-methylated flavonoid and antioxidant.
SGTC_2939 9044578 71.43 µM 0.517882114938999 0.314450129780681 no 1060 0.302270260647358 1409 2653634
SGTC_3074 9116018 49.47 µM 0.51625969979295 0.315007557677909 no 1061 0.302836519535831 1497 17027303
SGTC_2391 6285546 200 µM 0.515713353614604 0.315195365750933 no 1062 0.303027313325754 1422 846083
SGTC_380 3970-0968 6 µM 0.515297055698166 0.315338501432492 no 1063 0.303172728046448 1409 2891601
SGTC_433 pimozide 108 µM 0.514005903930911 0.315782614284018 no 1064 0.303623931468611 1399 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_393 acivicin 6.25 µM 0.513454221137539 0.315972455817436 no 1065 0.303816812850876 1447 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_848 0368-0089 85.6 µM 0.509750649916797 0.317248159667236 no 1066 0.305113081759709 1444 762535
SGTC_1644 st010134 20.9 µM 0.506348734404125 0.318421874350784 no 1067 0.306305928326087 1448 3818134
SGTC_3305 9127027 53.8275 µM 0.505874633237912 0.318585591897679 no 1068 0.306472330513087 1469 41905295
SGTC_2856 9022925 19.48 µM 0.504686824588135 0.318995923814155 no 1069 0.3068894082122 1492 4944862
SGTC_1947 st076332 61.6 µM 0.503060744421352 0.319558017685444 no 1070 0.307460782552002 1488 24208416
SGTC_2523 spermine 47.74 µM 0.502968113277385 0.319590050376493 no 1071 0.30749334550144 1532 1103 A DNA binding polyamine.
SGTC_1516 st013856 110 µM 0.502638224714248 0.319704139769656 no 1072 0.307609324700897 1464 5281404 A mutagen and neurotoxin.
SGTC_1630 st005209 31.3 µM 0.502318393210648 0.319814767297436 no 1073 0.30772178649365 1501 3367314
SGTC_1119 parthenolide 318.541 nM 0.502181372711717 0.319862166655342 no 1074 0.307769972301542 1585 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_400 oxethazaine 37.5 µM 0.502017262105497 0.319918941136958 no 1075 0.307827689213515 1466 4621 A local anesthetic.
SGTC_2931 9014674 55.67 µM 0.500402054126562 0.32047795134553 no 1076 0.308396003639023 1433 2996810
SGTC_2250 alverine citrate 130 µM 0.499585449897004 0.320760726540671 no 1077 0.308683502566086 1452 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1912 st060209 90.8 µM 0.499461870220386 0.320803529002331 no 1078 0.30872702104392 1435 688787
SGTC_151 3013-0144 2.285 µM 0.499350735128996 0.320842023251808 no 1079 0.308766159465738 1556 906558 YHR107C CDC12
SGTC_1778 st046819 58.9 µM 0.499031804081276 0.320952503206199 no 1080 0.308878489405328 1494 671715
SGTC_1075 aripiprazole 15.2 µM 0.498496001556685 0.321138144651435 no 1081 0.309067243373502 1473 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1198 1612-1005 86.7 µM 0.497467789236573 0.321494518295861 no 1082 0.309429605989229 1541 6998509
SGTC_544 k015-0020 52.4 µM 0.496373184276919 0.321874083951515 no 1083 0.309815570434235 1494 3008304
SGTC_666 0272-0154 136 µM 0.495301456155372 0.322245896989402 no 1084 0.310193671601526 1488 6870312
SGTC_1753 st043925 64 µM 0.49241202843977 0.323249207529909 no 1085 0.311214048862943 1525 670181
SGTC_1290 0986-0249 10.2 µM 0.492011588623965 0.323388355963959 no 1086 0.311355575608262 1466 53329
SGTC_2326 6164455 177.58 µM 0.491486074943328 0.323571003676162 no 1087 0.311541349300557 1500 2888790
SGTC_1248 0469-0687 58.6 µM 0.490240953068894 0.324003928284318 no 1088 0.311981702274268 1559 4017482
SGTC_1612 st002233 45.4 µM 0.489868924338032 0.324133327633561 no 1089 0.312113327097269 1506 1035021
SGTC_1669 st015249 58.4 µM 0.489787781740626 0.324161553543914 no 1090 0.312142038766327 1556 722793
SGTC_2532 xanthone 78.9 µM 0.488910599551182 0.324466750810163 no 1091 0.312452495590675 1553 7020 An insecticide.
SGTC_2314 7727897 200 µM 0.488031653112303 0.324772680207706 no 1092 0.312763710401356 1463 900724
SGTC_1143 3454-2408 5.08 µM 0.486704393377481 0.325234875243815 no 1093 0.313233915679709 1478 X1143
SGTC_1801 st050089 28.441 µM 0.483921960338266 0.326204681378656 no 1094 0.314220627279818 1499 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1405 3909-7894 12 µM 0.482742002101884 0.326616306828598 no 1095 0.314639468058366 1584 7104060
SGTC_954 1189-0853 2.85 µM 0.482653612814085 0.326647149715965 no 1096 0.314670852543395 1491 2828194
SGTC_1417 3966-0327 90.4 µM 0.481861588947117 0.326923574329143 no 1097 0.314952137089439 1550 651118
SGTC_1067 clotrimazole 1.36 µM 0.480264815130568 0.327481153801339 no 1098 0.3155195521079 1504 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_704 1310-0270 142 µM 0.47951586806092 0.327742812311298 no 1099 0.315785841162929 1464 5718033
SGTC_3000 9075062 71.4286 µM 0.479310250716381 0.327814663340738 no 1100 0.315858965403145 1494 17057871
SGTC_1061 3448-9325 110 µM 0.477543347309227 0.328432353486327 no 1101 0.316487630747665 1498 723482
SGTC_2904 7225135 42.03 µM 0.476619038773922 0.328755668713515 no 1102 0.316816711818228 1552 4446116
SGTC_791 1348-1292 225 µM 0.47433174293548 0.329556296034053 no 1103 0.317631679466146 1570 5437054
SGTC_2919 7978188 46.38 µM 0.473814406857209 0.329737488899264 no 1104 0.317816130040143 1626 2980291
SGTC_39 0986-0283 58.349 µM 0.472888469477662 0.330061890896213 no 1105 0.318146375849742 1665 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2162 5663267 200 µM 0.470535507480778 0.330886825359881 no 1106 0.318986236029304 1615 6456493
SGTC_1603 st002045 67.8 µM 0.469490846938028 0.331253340813709 no 1107 0.319359412906986 1548 5887985
SGTC_2681 menadione 3.18 µM 0.469399771878399 0.331285301844591 no 1108 0.319391955702718 1531 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2378 9074213 121.43 µM 0.467989993539731 0.331780192915497 no 1109 0.31989587277733 1501 657714
SGTC_1545 lovastatin 49.4 µM 0.467621393812607 0.331909635282369 no 1110 0.320027681484552 1567 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3021 9087658 49.47 µM 0.466752717184266 0.332214770629241 no 1111 0.320338404070196 1530 25237042
SGTC_902 1120-0002 2.07 µM 0.465687182765762 0.332589207086694 no 1112 0.320719714058757 1485 3280475
SGTC_1089 terbinafine 2.25 µM 0.461949614019002 0.33390393452978 no 1113 0.322058726809084 1588 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1482 3346-2049 8.48 µM 0.461382915924348 0.334103454912423 no 1114 0.322261953139708 1575 3826804
SGTC_526 4469-0568 170 µM 0.461018457868897 0.33423179635994 no 1115 0.322392681279261 1505 2901964
SGTC_1149 3909-7961 23.3 µM 0.459429761252337 0.334791471392048 no 1116 0.322962790232975 1501 735261
SGTC_1106 tegaserod maleate 11.7 µM 0.45818639074774 0.335229749209242 no 1117 0.323409268225667 1584 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_559 1550-0661 158 µM 0.456621251338253 0.335781766879252 no 1118 0.323971650845742 1607 5830875
SGTC_2968 9090663 33.37 µM 0.454011695148574 0.336702933546436 no 1119 0.324910204608351 1567 25236811
SGTC_2338 7999974 200 µM 0.45386132380202 0.336756044180526 no 1120 0.324964321164472 1665 315925
SGTC_293 4049-0273 38.5 µM 0.453688508784102 0.336817085861787 no 1121 0.32502651944719 1514 1380311
SGTC_3091 9116372 49.47 µM 0.453568181859961 0.336859590249192 no 1122 0.325069829489612 1543 17169793
SGTC_190 3970-0790 3.722 µM 0.450430301806767 0.337968751973014 no 1123 0.326200099908287 1608 2832352
SGTC_3159 9100096 49.47 µM 0.447998811618747 0.338829191662268 no 1124 0.327077027131959 1477 25236875
SGTC_457 grayanotoxin iii 135 µM 0.445587142526089 0.339683448744095 no 1125 0.327947749910774 1532 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2843 9000894 45.46 µM 0.445098302663939 0.339856705318331 no 1126 0.328124357691224 1501 2242070
SGTC_636 0kpi-0074 126 µM 0.443915191238118 0.340276168366162 no 1127 0.328551950492871 1555 616434
SGTC_2515 chrysin 20.77 µM 0.442424003563272 0.340805139090446 no 1128 0.329091206230348 1643 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3124 9127567 49.47 µM 0.442118840995042 0.340913428396236 no 1129 0.329201605564588 1675 17592030
SGTC_1531 st059297 52.4 µM 0.439249704534992 0.341932203680051 no 1130 0.330240306649534 1578 7566702
SGTC_2074 5212007 75.395 µM 0.438310510954514 0.342265943936209 no 1131 0.33058060374954 1667 758611
SGTC_602 3130-1533 38.1 µM 0.437487385168851 0.342558541112987 no 1132 0.330878961337465 1643 720941
SGTC_1734 st037168 69.4 µM 0.437400052919092 0.342589590725208 no 1133 0.330910622879854 1564 708907
SGTC_2187 6125751 200 µM 0.434665766906834 0.343562260273019 no 1134 0.331902525056502 1595 874498
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.434499602936773 0.34362140338282 no 1135 0.331962841543533 1583 97141
SGTC_1422 4031-0024 15.5 µM 0.433963352158306 0.343812298416174 no 1136 0.33215752693741 1572 782427
SGTC_2993 9054257 71.4286 µM 0.433832226397684 0.343858982743898 no 1137 0.332205138930629 1537 6470217 YGL055W OLE1
SGTC_709 3807-1509 243 µM 0.433065451434392 0.344132023075666 no 1138 0.332483610469187 1604 1886677 YPL242C IQG1
SGTC_3156 9099931 49.47 µM 0.431321427628677 0.344753353719232 no 1139 0.333117336056773 1619 18111053
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.431240998216958 0.344782017838194 no 1140 0.333146573191863 1566 3256 An antibiotic and ribosome inhibitor.
SGTC_3070 9117005 49.47 µM 0.429415654328059 0.345432788736346 no 1141 0.333810381755424 1646 8779016
SGTC_423 5-fluorouracil 457 µM 0.428111182089503 0.345898138906064 no 1142 0.33428508800823 1494 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2597 laccaic acid a 100 µM 0.427677184388264 0.346053012492298 no 1143 0.334443081522263 1594 5491415 A textile dye.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.427597333636147 0.346081510316313 no 1144 0.334472153767516 1570 442882
SGTC_76 0433-0009 400.328 µM 0.427484440506502 0.346121802075937 no 1145 0.334513257851236 1586 2841569
SGTC_2917 7979103 53.79 µM 0.426982624239237 0.346300922273867 no 1146 0.334695991800136 1682 2980565
SGTC_2283 7944793 200 µM 0.426574340668086 0.346446681926848 no 1147 0.334844695165467 1513 2970533
SGTC_1737 st035557 69.7 µM 0.426001057000427 0.346651385971887 no 1148 0.335053537900698 1537 5716916
SGTC_845 0330-0138 4.51 µM 0.425764650143462 0.346735813491694 no 1149 0.335139673918853 1683 9039800
SGTC_1195 1502-0147 41.1 µM 0.423192575179091 0.347654864735121 no 1150 0.336077381755574 1567 817940
SGTC_2941 9056145 11.23 µM 0.423089585758141 0.347691683504983 no 1151 0.336114950166156 1541 2119517
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.422886152823315 0.347764415102814 no 1152 0.336189163103192 1742 551469
SGTC_662 k832-1615 104 µM 0.422405215808287 0.347936382582912 no 1153 0.336364635735116 1647 5878478
SGTC_1995 st072814 61.1 µM 0.421924280917182 0.348108380586125 no 1154 0.336540143242816 1547 5769371
SGTC_20 0481-0013 4.944 µM 0.419247515353159 0.349066249385877 no 1155 0.337517624813097 1559 182045
SGTC_2086 5274770 176.623 µM 0.41918038467348 0.349090284201142 no 1156 0.337542153233493 1600 689278
SGTC_1556 plumbagin 1.48 µM 0.419117209182751 0.349112903491963 no 1157 0.337565237124857 1576 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_59 0330-0160 1.33 µM 0.418275658836412 0.349414262456613 no 1158 0.337872792124431 1650 4293482
SGTC_2518 prenyletin 46.28 µM 0.417857013900125 0.34956421447902 no 1159 0.33802583144464 1639 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2544 sphondin 68.51 µM 0.417553328271564 0.349673004581378 no 1160 0.338136863140452 1664 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1760 st045453 10.4495 µM 0.416852446147479 0.3499241305437 no 1161 0.338393169140742 1652 3323419 YIL048W NEO1
SGTC_3300 9124615 50.48 µM 0.415783793811557 0.350307154869187 no 1162 0.338784109366667 1673 24824903
SGTC_1000 4048-0884 8.67 µM 0.414242452708877 0.350859867556802 no 1163 0.339348277096697 1635 13040088
SGTC_3176 9106582 49.47 µM 0.412221341140145 0.351585100481828 no 1164 0.340088598148526 1604 17018027
SGTC_302 1094-0063 18.9 µM 0.412191877866887 0.351595676754698 no 1165 0.340099394938181 1589 5440289
SGTC_1534 6-azauridine 81.6 µM 0.411610337952298 0.35180445251365 no 1166 0.340312526535791 1606 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.410799727491809 0.352095540313709 no 1167 0.340609696508359 1715 688664
SGTC_1936 st074407 74.3 µM 0.40898489636308 0.352747554842679 no 1168 0.341275372597291 1575 809813
SGTC_3050 9093513 49.47 µM 0.408905444642295 0.352776109370287 no 1169 0.341304526621114 1592 25236664
SGTC_1874 staurosporine 7.6 µM 0.408376026692949 0.352966400546003 no 1170 0.341498815482128 1687 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_715 0868-0130 184 µM 0.407891165838425 0.353140708626521 no 1171 0.341676789379278 1769 2876258
SGTC_2726 cimetidine 79.27 µM 0.407652651358992 0.353226466189842 no 1172 0.341764351852563 1636 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2450 5739737 12.93 µM 0.407087112458284 0.353429834730963 no 1173 0.34197200423191 1614 2262825
SGTC_2690 usnic acid 100 µM 0.406642149068448 0.353589873580536 no 1174 0.342135417773814 1754 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2512 diallyl trisulfide 49.23 µM 0.406321105870004 0.353705358446775 no 1175 0.342253339786336 1609 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_616 4092-0450 108 µM 0.405970392533611 0.353831531570355 no 1176 0.342382177484965 1646 787165
SGTC_3202 9113761 49.47 µM 0.405214475804084 0.35410353581956 no 1177 0.342659932659785 1767 4798415
SGTC_456 gingerol 170 µM 0.404251283899382 0.354450232521036 no 1178 0.343013972607135 1674 442793 A herb.
SGTC_91 0417-1751 58.384 µM 0.403683651691961 0.354654605759849 no 1179 0.343222681470979 1631 6795624
SGTC_3142 9086498 49.47 µM 0.402830767706801 0.354961761183137 no 1180 0.343536362545356 1699 25236367
SGTC_3330 9141424 71.43 µM 0.402502829184654 0.35507988921894 no 1181 0.343657003322501 1720 27261020
SGTC_3195 9113082 49.47 µM 0.39943712810078 0.356184870005022 no 1182 0.344785570629199 1731 17018038
SGTC_3086 9117350 49.47 µM 0.398968921631305 0.356353733844382 no 1183 0.344958052011905 1568 2679265
SGTC_2448 5185112 27.17 µM 0.396892196898177 0.357103066741473 no 1184 0.345723479307828 1624 5718189
SGTC_266 formosanin C 406 nM 0.396614439132922 0.357203330390457 no 1185 0.345825901586311 1645 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3238 9133470 49.47 µM 0.395491549239778 0.357608766177074 no 1186 0.346240078552999 1719 3534688
SGTC_2481 5478948 45.16 µM 0.392732258706499 0.358605730263404 no 1187 0.34725862106531 1624 77792
SGTC_1319 1306-0155 43.7 µM 0.392377851080215 0.358733851927059 no 1188 0.347389524441428 1666 3122360
SGTC_2608 thymoquinone 42.66 µM 0.391023282042087 0.359223687661736 no 1189 0.347890013313474 1601 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_262 fenpropimorph 62.5 µM 0.388625394412913 0.360091372743013 no 1190 0.348776639298538 1600 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_667 1498-1044 59 µM 0.387057865479945 0.360658979455622 no 1191 0.3493566847965 1681 6739982
SGTC_315 k915-0449 187 µM 0.386313536288651 0.360928610806711 no 1192 0.349632238331717 1702 20970215 YNL149C PGA2
SGTC_306 1672-3436 11.6 µM 0.385210179791583 0.361328426041188 no 1193 0.350040850920664 1681 6797378
SGTC_134 0269-0018 6.916 µM 0.385050538154638 0.361386286771229 no 1194 0.350099986354575 1594 4378915
SGTC_2085 5307070 144.047 µM 0.384666665326797 0.361525431132208 no 1195 0.350242197758443 1618 2840351
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.383792736137037 0.361842277033693 no 1196 0.350566036137739 1727 688761
SGTC_2847 9005661 71.43 µM 0.382882381213568 0.362172429938196 no 1197 0.350903487755297 1655 2991449
SGTC_861 0443-0273 110 µM 0.382636499019677 0.362261620145982 no 1198 0.350994651894089 1692 6149169
SGTC_914 3820-6779 408 µM 0.381676131751602 0.362610051078661 no 1199 0.351350803140998 1597 2893481
SGTC_1743 st037606 46.3785 µM 0.381511694041788 0.362669722158374 no 1200 0.351411797802465 1655 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.379857517663206 0.363270174237641 no 1201 0.352025591879352 1652 2346 DNA damaging agent; causes G2/M arrest.
SGTC_194 1486-1323 56.904 µM 0.379774458807935 0.363300332777224 no 1202 0.352056421650851 1614 5178754
SGTC_138 0850-0259 40.9225 µM 0.378817001203346 0.363648045271485 no 1203 0.352411880771531 1648 6813004
SGTC_859 0439-0102 54.6 µM 0.378668629774328 0.363701938239502 no 1204 0.352466975673644 1768 610143
SGTC_920 mycophenolic acid 780.421 nM 0.37813579983926 0.363895500332642 no 1205 0.35266485742574 1617 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2472 5377652 49.4 µM 0.375877965585436 0.364716092770307 no 1206 0.353503811132125 1640 1610903
SGTC_992 3909-8734 162 µM 0.375849472004892 0.364726452512778 no 1207 0.353514403179978 1635 4288319
SGTC_931 2812-0076 566 µM 0.375784707822775 0.364749999947108 no 1208 0.353538478684881 1643 3450959
SGTC_1242 0402-0103 60.1 µM 0.374024319936335 0.365390249780744 no 1209 0.354193111252213 1629 432868
SGTC_643 k048-0106 28.4 µM 0.372009930891221 0.366123339750358 no 1210 0.354942727689161 1727 6763920
SGTC_1278 0874-0585 172 µM 0.371394350167933 0.366347463680353 no 1211 0.355171916530942 1706 766306
SGTC_442 cape 100 µM 0.368860796615151 0.367270372683985 no 1212 0.35611574287178 1784 5281787
SGTC_1759 st043059 70 µM 0.367349199717157 0.367821374772391 no 1213 0.356679279683909 1606 669426
SGTC_2471 5466956 24.79 µM 0.366959183751608 0.367963586256971 no 1214 0.356824731960468 1710 724419
SGTC_2766 oltipraz 83.91 µM 0.366142409258337 0.368261465283507 no 1215 0.357129406687341 1766 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_878 0828-0289 13.7 µM 0.365581305415583 0.368466146706365 no 1216 0.357338763492369 1667 745350 YLR208W SEC13
SGTC_555 4296-0685 37 µM 0.363854932120219 0.369096133084319 no 1217 0.357983170052872 1722 2908540 YHR072W ERG7
SGTC_172 1112-0046 2.638 µM 0.36384710980415 0.369098988397759 no 1218 0.357986090826047 1685 2802135 YIL048W NEO1
SGTC_2096 5468907 200 µM 0.363667472028064 0.369164562033115 no 1219 0.358053168029784 1803 759785
SGTC_676 falcarinol 140 µM 0.363213527162219 0.369330283648403 no 1220 0.358222691724819 1806 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2199 6590217 200 µM 0.363097056344151 0.369372807556487 no 1221 0.35826619174214 1741 703109
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.362888798160845 0.36944884734014 no 1222 0.35834397748094 1657 2724 A muscle relaxant with antifungal properties.
SGTC_1867 st057372 64 µM 0.362346200608471 0.369646985986696 no 1223 0.35854666867717 1692 688837
SGTC_1633 st005664 67.9 µM 0.361896696785831 0.36981115610955 no 1224 0.358714614231542 1637 2063822
SGTC_74 000s-0487 160.283 µM 0.359035229273846 0.370856791374319 no 1225 0.359784367384853 1624 677548
SGTC_2014 4013930 200 µM 0.358694476726873 0.370981372652753 no 1226 0.359911830370828 1751 64556
SGTC_2224 6650123 117.647 µM 0.358546865108363 0.371035344589654 no 1227 0.359967051281522 1700 2908370
SGTC_153 4077-0274 519.67 µM 0.353437280249727 0.372905143366102 no 1228 0.361880320666975 1827 3121976
SGTC_2435 5706476 10.6 µM 0.352052889126963 0.373412264772374 no 1229 0.362399299214932 1842 5725375
SGTC_2650 prasterone 100 µM 0.349006933065604 0.374528811177417 no 1230 0.363542052311264 1736 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2043 5101342 149 µM 0.348420850994658 0.37474377049078 no 1231 0.363762072783481 1720 678451
SGTC_1814 st052110 31.539 µM 0.347254867330034 0.375171537976332 no 1232 0.364199927074413 1811 674163
SGTC_865 0488-0499 301 µM 0.345346646180013 0.375871943191911 no 1233 0.364916891323975 1771 9634651
SGTC_1471 k673-0312 37 µM 0.345141775893015 0.375947164403001 no 1234 0.36499389411861 1750 24099884
SGTC_3157 9099274 49.47 µM 0.342913767073098 0.376765515219892 no 1235 0.365831667210465 1843 17217662
SGTC_1451 4152-0210 104 µM 0.341943771543601 0.377121969290986 no 1236 0.366196604001699 1822 659563
SGTC_2558 carylophyllene oxide 100 µM 0.339723434540384 0.377938292812624 no 1237 0.36703240603215 1745 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2944 9067346 25.62 µM 0.339683860321872 0.37795284752754 no 1238 0.367047308696929 1754 6473075
SGTC_1655 st012546 55.1 µM 0.339080257988492 0.378174863514694 no 1239 0.367274635116208 1729 720985 YLR208W SEC13
SGTC_714 4296-0578 26.1 µM 0.337535521556298 0.378743228928 no 1240 0.367856619633821 1838 1589775
SGTC_609 0986-0026 86.3 µM 0.337316041803663 0.378824004924121 no 1241 0.367939334005771 1784 2848610
SGTC_2593 nobiletin 86.24 µM 0.33449101651574 0.379864181455632 no 1242 0.369004534349202 1666 72344 An anti-infammatory.
SGTC_2249 haloperidol 116.36 µM 0.333325338751542 0.380293638852926 no 1243 0.369444357206864 1774 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_71 0417-1750 47.813 µM 0.332566529452872 0.38057327768217 no 1244 0.36973075606278 1880 6811472
SGTC_2047 4141938 200 µM 0.331829844359301 0.380844822941164 no 1245 0.370008873691312 1744 3807862
SGTC_2075 5212009 200 µM 0.331540791265166 0.380951385183433 no 1246 0.370118017272787 1814 780898
SGTC_2255 7941087 197.44 µM 0.331026660202995 0.381140946923548 no 1247 0.370312173906048 1849 935561
SGTC_1231 0242-0792 125 µM 0.330714052565773 0.381256220290648 no 1248 0.370430243321233 1687 3707635
SGTC_2898 9056270 58.44 µM 0.329899227213911 0.381556734816373 no 1249 0.370738053719092 1746 19154699
SGTC_532 1548-0774 215 µM 0.329619533715593 0.381659904631796 no 1250 0.370843730499485 1852 5932993
SGTC_1780 st038448 24.544 µM 0.325482834171155 0.383186776306732 no 1251 0.372407836163008 1822 728868 YDL195W SEC31
SGTC_1705 st027868 56.3335 µM 0.32402782964988 0.3837242571091 no 1252 0.372958482453557 1832 292948
SGTC_1233 0325-0408 14.2 µM 0.322241228491412 0.38438453621046 no 1253 0.37363497652597 1819 12874
SGTC_1525 8-methoxypsoralen 92.5 µM 0.321943344716301 0.384494658630006 no 1254 0.373747807753094 1908 4114 Related to psoralen; DNA damaging agent.
SGTC_2980 9014342 25.29 µM 0.321412839787097 0.384690800098494 no 1255 0.373948777082902 1738 2996599
SGTC_2416 tofa 880 nM 0.319863169492326 0.385263922389191 no 1256 0.374536029351281 1622 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1706 st031321 9.9705 µM 0.319058916809359 0.385561462061567 no 1257 0.374840918195699 1841 6103185
SGTC_2144 5628481 200 µM 0.318420630955413 0.385797648938609 no 1258 0.37508294540616 1749 2818399
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.318297893498866 0.385843070713832 no 1259 0.375129491017961 1819 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1626 st003712 1.76 µM 0.318119897892295 0.385908944799491 no 1260 0.37519699535733 1789 24207035
SGTC_3136 9095672 49.47 µM 0.318030872830989 0.385941893164564 no 1261 0.375230759298675 1893 17217380
SGTC_2008 4012253 172 µM 0.317677773024236 0.386072584257506 no 1262 0.375364686520603 1729 603940
SGTC_962 1254-0300 21.5 µM 0.317549962470345 0.386119893336334 no 1263 0.375413167488262 1759 7340576
SGTC_989 1501-0895 10.3 µM 0.316649077863826 0.386453403785635 no 1264 0.375754945883625 1894 2830112
SGTC_1764 st044502 93.5 µM 0.316476827212066 0.386517181105996 no 1265 0.37582030559979 1745 8407
SGTC_390 dec-rvkr-cmk 16.7 µM 0.316098821045242 0.386657151960552 no 1266 0.375963750784972 1789 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3217 9129673 49.47 µM 0.315935527852109 0.386717621905923 no 1267 0.376025722331605 1763 17248312
SGTC_339 3091-4833 71.4 µM 0.315875317286919 0.386739919485293 no 1268 0.376048573704239 1790 3240077
SGTC_81 0411-0046 9.971 µM 0.314866950335259 0.387113400190121 no 1269 0.37643133799632 1746 12925265
SGTC_1298 1079-1278 263 µM 0.31436677019002 0.387298696589594 no 1270 0.376621245645497 1767 2840950
SGTC_1315 1237-0019 3.69 µM 0.314072936506165 0.387407561995204 no 1271 0.376732821906415 1835 825140
SGTC_579 4491-1009 110 µM 0.313658092251209 0.387561276901518 no 1272 0.37689036654541 1937 1271041
SGTC_2385 9074692 200 µM 0.31073013860734 0.388646690308439 no 1273 0.378002891677575 1730 17046906
SGTC_299 1273-0059 1.44 µM 0.310660591270792 0.388672482615196 no 1274 0.378029329701758 1814 2848077
SGTC_2514 salinomycin 42.74 µM 0.309842517066455 0.388975910208565 no 1275 0.378340358801156 1916 23682228 A polyether potassium ionophore.
SGTC_179 1273-0063 6.77 µM 0.30934050552814 0.389162142209612 no 1276 0.378531260973373 1719 3108139
SGTC_3178 9107506 49.47 µM 0.308862590642935 0.389339458699539 no 1277 0.378713027351689 1800 8897194
SGTC_2012 4023501 200 µM 0.308451972444521 0.389491825107779 no 1278 0.378869220071287 1713 3477460
SGTC_3105 9121040 49.47 µM 0.308388053772786 0.389515544675461 no 1279 0.37889353551119 1874 41448907
SGTC_3344 9148862 3.898 µM 0.307856053399047 0.389712980553659 no 1280 0.379095933509588 1860 4905352
SGTC_1483 3453-0561 55.9 µM 0.307320112040923 0.389911907790418 no 1281 0.379299864364574 1830 4546991
SGTC_34 0469-0683 81.75 µM 0.307108945569487 0.389990295113983 no 1282 0.379380224471322 1833 3690923
SGTC_957 1187-1561 14.1 µM 0.305850683596303 0.39045746848841 no 1283 0.37985916820774 1800 1538454
SGTC_119 0121-0043 24.815 µM 0.305674099825521 0.390523044008657 no 1284 0.379926397666864 1829 1092378
SGTC_3168 9103419 49.47 µM 0.304076651242317 0.391116408125564 no 1285 0.380534747361935 1862 16649256
SGTC_1041 0206-0046 107 µM 0.302664710696187 0.391641077365033 no 1286 0.381072696930674 1761 50494
SGTC_2868 9035608 32.47 µM 0.302044612053252 0.391871564932785 no 1287 0.381309027336006 1720 6462614
SGTC_2088 5278280 127.392 µM 0.301482293033924 0.392080608919853 no 1288 0.381523375194666 1791 791502
SGTC_166 k072-0058 166.424 µM 0.300612709827785 0.39240394072125 no 1289 0.381854919238331 1897 5846229
SGTC_497 capsazepine 133 µM 0.297966132215724 0.393388457713317 no 1290 0.382864506363696 1689 2733484 A calcium channel blocker.
SGTC_1568 digitonin 820 nM 0.296746921451501 0.393842229441853 no 1291 0.383329865745942 1964 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_160 3453-0671 289.699 µM 0.295766554739858 0.394207211652122 no 1292 0.383704183145736 1734 5322268
SGTC_1996 st072960 66.8 µM 0.294711177106856 0.3946002236418 no 1293 0.384107262059389 1914 1719405
SGTC_346 4513-0042 7.16 µM 0.293620486643647 0.395006498519498 no 1294 0.384523959701678 1761 2827372
SGTC_2557 derrustone 83.84 µM 0.292526935417443 0.395413953647078 no 1295 0.384941884290324 1729 629853 An antioxidant.
SGTC_3025 9087895 49.47 µM 0.292126462950738 0.395563197565371 no 1296 0.385094967102038 1898 17173641
SGTC_1663 st014140 55.4 µM 0.290360015025604 0.396221681521741 no 1297 0.38577041499971 1848 4207120
SGTC_889 0919-1524 82.7 µM 0.290209293243904 0.396277880261334 no 1298 0.385828063515877 1777 3905452
SGTC_2829 7992743 58.44 µM 0.290073766081695 0.396328415313426 no 1299 0.385879902501884 1987 16462845
SGTC_1444 4112-3581 28 µM 0.289213811382747 0.396649113774681 no 1300 0.386208881656395 1813 2877249
SGTC_1976 st070609 63.5 µM 0.289089693344549 0.396695406252614 no 1301 0.386256370277755 1797 682556
SGTC_1090 efavirenz 20.7 µM 0.288334035075494 0.396977276566488 no 1302 0.386545528327526 1850 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_833 3852-0053 558 µM 0.287803030347234 0.397175380414176 no 1303 0.386748758794813 1849 3123681
SGTC_490 phenamil 164 µM 0.286840105755249 0.397534689809326 no 1304 0.38711737635821 1887 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_760 0568-0725 82.9 µM 0.286836805479929 0.397535921436479 no 1305 0.387118639913255 1920 3916171
SGTC_2259 7964009 200 µM 0.285947160503243 0.397867964558247 no 1306 0.387459296104927 1847 313134
SGTC_693 4161-2696 114 µM 0.285019804033686 0.398214161543817 no 1307 0.387814484755098 1884 805759
SGTC_529 4076-0302 30.3 µM 0.284162465581461 0.398534290984902 no 1308 0.388142939198955 1781 5816522
SGTC_707 0865-0008 204 µM 0.284053684577433 0.398574914604778 no 1309 0.388184619953102 1862 723043
SGTC_3047 9092122 49.47 µM 0.283492290538892 0.398784581336111 no 1310 0.38839974531686 1767 17173831
SGTC_1685 st024049 53.0905 µM 0.283417888820787 0.398812370723673 no 1311 0.388428258515979 1833 1941139
SGTC_84 0443-0269 128.823 µM 0.282487891295924 0.399159772358177 no 1312 0.38878471500763 1882 6150058
SGTC_2653 dihydrofissinolide 100 µM 0.281632018037184 0.39947955538213 no 1313 0.389112843354294 1843 6857746
SGTC_876 0720-0963 56.8 µM 0.277887114368563 0.400879567850601 no 1314 0.390549507864911 1959 765861
SGTC_2792 7535235 81.82 µM 0.277216043684673 0.401130579204079 no 1315 0.390807110566706 1739 1281891
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.276375548384924 0.401445020732735 no 1316 0.391129817583839 1767 6708514
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.275891887705162 0.401625994182474 no 1317 0.391315552435625 1778 5282362
SGTC_1344 1488-0097 29.1 µM 0.273734448939052 0.402433509021984 no 1318 0.392144351041533 1854 747966
SGTC_3326 9140064 16.379 µM 0.273141190799758 0.40265563471835 no 1319 0.392372342222359 1766 1868434
SGTC_1824 st053723 68.6 µM 0.27244908060258 0.40291481198125 no 1320 0.39263836928496 1761 675225
SGTC_706 4262-0057 46.9 µM 0.272294819165558 0.402972584694506 no 1321 0.392697669743136 1781 883298
SGTC_919 tnp00227 403.569 nM 0.270614368469396 0.403602070112737 no 1322 0.393343821805988 1828 1269246 A methoxyflavone. YNL221C POP1
SGTC_2636 apigenin dimethyl ether 100 µM 0.26923202881272 0.404120072499062 no 1323 0.393875567242678 1859 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2924 9010168 62.78 µM 0.269032720543677 0.404194772926007 no 1324 0.393952251624784 1830 2993929
SGTC_634 1611-4317 11.2 µM 0.266587233475286 0.405111621242809 no 1325 0.394893493112648 1976 2843522
SGTC_3042 9091578 49.47 µM 0.266511174541986 0.405140145212681 no 1326 0.394922777241898 1914 25236497
SGTC_1410 3909-8106 77.9 µM 0.26517624147532 0.405640859838492 no 1327 0.395436848243586 1929 1039210
SGTC_1303 1160-0052 261 µM 0.263321096970492 0.406336954739394 no 1328 0.396151550138813 1918 3562476
SGTC_806 3966-4455 5.86 µM 0.262926189355954 0.406485171890866 no 1329 0.396303735047382 1781 714982
SGTC_8 0354-0001 70 µM 0.262676147254915 0.406579024890965 no 1330 0.396400101539126 1853 4993152
SGTC_1671 st016596 74.5 µM 0.261940576906957 0.406855151427264 no 1331 0.396683627811193 1835 2829167
SGTC_1786 berberine 21.6 µM 0.261161046416931 0.407147830751147 no 1332 0.39698415818675 1787 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1896 st058441 89 µM 0.259513060630027 0.407766747241629 no 1333 0.397619703096539 1811 688759
SGTC_1030 k029-0042 36.7 µM 0.258850465499048 0.408015656033476 no 1334 0.397875309301447 1853 6080581
SGTC_1026 k007-1105 30.6 µM 0.258571353493161 0.408120517655012 no 1335 0.397982994156479 1831 7066794
SGTC_1011 4112-3381 17.4 µM 0.258058144833554 0.408313345922064 no 1336 0.398181016665881 1892 2877139
SGTC_1714 st033236 13.627 µM 0.255606644974374 0.409234755341939 no 1337 0.399127293437815 1926 2916566
SGTC_438 sphingosine 6.67 µM 0.255318888517196 0.409342943153906 no 1338 0.399238406175261 1692 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2348 9022543 33.42 µM 0.25499157902321 0.409466010116948 no 1339 0.399364801634084 1866 3162678 YDL140C RPO21
SGTC_6 0844-0013 19.835 µM 0.254275207105633 0.409735393996246 no 1340 0.399641476164366 1944 1584900
SGTC_2140 5586273 200 µM 0.252874621623559 0.41026219195207 no 1341 0.400182550623281 1884 854421
SGTC_1835 st008666 49.2 µM 0.251850275916499 0.410647578594642 no 1342 0.400578397466248 1810 690455
SGTC_2087 5276107 200 µM 0.251728501607407 0.410693399138641 no 1343 0.400625462574456 1837 144405
SGTC_415 dibenzyl ketone 100 µM 0.25144102486178 0.410801574086285 no 1344 0.400736576495332 1974 7593
SGTC_1707 st032323 6.317 µM 0.251287582980942 0.410859315681658 no 1345 0.400795887290225 1885 3132057 YMR211W DML1
SGTC_141 0443-0274 32.331 µM 0.251044712815732 0.410950713913485 no 1346 0.400889770001292 2004 1627241
SGTC_3094 9117742 49.47 µM 0.250849271818412 0.411024266851747 no 1347 0.400965322880557 1903 17149698
SGTC_2023 5144124 124 µM 0.250797705687269 0.411043673948872 no 1348 0.400985257748157 1848 2830192
SGTC_2754 granisetron 64.02 µM 0.250484184949257 0.411161673279778 no 1349 0.401106466772491 1977 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1449 4112-4002 201 µM 0.249926025974425 0.411371766624469 no 1350 0.401322277978702 1804 2059539
SGTC_2451 5856223 45.7 µM 0.248438567374469 0.411931776158697 no 1351 0.401897548140416 1822 2179896
SGTC_2114 5491910 81.25 µM 0.248002767992855 0.412095883200511 no 1352 0.40206613257386 1930 2849228
SGTC_2502 avocadyne acetate 18.59 µM 0.247968838250684 0.412108660618553 no 1353 0.402079258704744 1856 3952079
SGTC_1023 4482-3888 16 µM 0.247878394167143 0.412142720921833 no 1354 0.402114248631219 1958 3303168
SGTC_2091 4-phenylthiadiazole 200 µM 0.247569613011203 0.412259009685878 no 1355 0.402233712104875 1853 270010
SGTC_1915 st067105 30.6 µM 0.247320665984282 0.412352770181638 no 1356 0.402330033170645 1870 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2521 angolensin 13.4 µM 0.247062771734706 0.412449905729856 no 1357 0.40242982229538 1891 821428 A flavenoid.
SGTC_2513 baicalein 25.65 µM 0.246351547207276 0.412717815333135 no 1358 0.402705055128882 1795 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1048 3161-0300 24.5 µM 0.246261971112033 0.4127515604413 no 1359 0.402739723107236 1864 2165101
SGTC_1320 1313-0481 95.3 µM 0.245875163893496 0.412897285864364 no 1360 0.402889435042568 1987 6813365 YLR208W SEC13
SGTC_2811 7967822 32.47 µM 0.245867656025599 0.412900114490964 no 1361 0.402892341068868 1922 2232244
SGTC_1452 4194-0072 190 µM 0.243513320112202 0.413787344593413 no 1362 0.403803883832615 2008 1343545
SGTC_2111 5486399 200 µM 0.243390355702362 0.413833695796093 no 1363 0.403851507127512 1849 689674
SGTC_63 0099-0242 26.702 µM 0.242659019239403 0.41410939647976 no 1364 0.404134778280861 2007 3898502 YLR359W ADE13
SGTC_538 2922-0838 53.3 µM 0.242622464987372 0.414123177886819 no 1365 0.404148938289749 2001 777039
SGTC_1200 1643-0193 18.4 µM 0.241521494350956 0.414538306972992 no 1366 0.40457547970367 1985 5403974
SGTC_1981 st071826 47 µM 0.239360986940345 0.415353219300738 no 1367 0.405412839358937 1881 11838600
SGTC_525 k781-2675 26.7 µM 0.238227892372591 0.415780752115176 no 1368 0.405852172394394 1973 3651118 YDL195W SEC31
SGTC_2238 6671620 73.2395 µM 0.23651604127951 0.416426847002824 no 1369 0.406516130597811 1828 729941
SGTC_1135 dihydrocapsaicin 536.708 nM 0.236206919803104 0.416543541210196 no 1370 0.406636055102291 1750 107982 A Capsaicinoid.
SGTC_3112 9123419 49.47 µM 0.236062958901368 0.416597889357506 no 1371 0.406691908108926 1992 17015854
SGTC_1501 4491-0275 38.4 µM 0.232988494992027 0.417758940527694 no 1372 0.407885169811235 2014 5104718
SGTC_1439 4092-1168 46 µM 0.23086087752529 0.418562841894357 no 1373 0.408711442483469 1944 2886240
SGTC_2981 9013952 38.96 µM 0.23074539035927 0.418606487460051 no 1374 0.408756304246543 1764 2996344
SGTC_2267 7931562 200 µM 0.230613414265337 0.418656365841824 no 1375 0.40880757270778 1754 934880
SGTC_2678 equilin 100 µM 0.230330294926052 0.418763370953253 no 1376 0.408917560714287 2013 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2638 epoxomicin 18 µM 0.228232275177401 0.419556505477431 no 1377 0.409732835764469 2011 9915668 A protesome inhibitor.
SGTC_1553 gossypol 38.6 µM 0.227729124273739 0.419746765162279 no 1378 0.409928414686156 1971 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_268 camptothecin 39.6153 µM 0.227246713660432 0.419929199805001 no 1379 0.410115952730348 1911 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2715 st079500 56.4 µM 0.226946677545802 0.420042674028126 no 1380 0.410232602713983 1868 28246688
SGTC_271 rotenone 740 µM 0.226016116206467 0.42039465631561 no 1381 0.410594442855307 1979 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1831 st055328 12 µM 0.225788672001078 0.420480696158602 no 1382 0.410682894010081 2006 1103068
SGTC_1777 st045864 34.765 µM 0.225128149013882 0.420730586850124 no 1383 0.410939791627105 1957 4691462
SGTC_187 1488-2104 32.728 µM 0.224301413953094 0.42104340430891 no 1384 0.411261388030941 1996 2852859
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.224245881557271 0.42106441827431 no 1385 0.411282992035443 1876 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2156 5649887 115 µM 0.224011347769843 0.421153170479723 no 1386 0.411374236680553 2004 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_557 1315-0110 16.2 µM 0.223139814363894 0.421483010963673 no 1387 0.411713346027347 1886 6833801
SGTC_195 4234-0266 16.654 µM 0.223091570561531 0.421501270922035 no 1388 0.41173211938149 1907 2303354
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.221989097455821 0.421918595591436 no 1389 0.412161185286405 1984 688801
SGTC_2316 5844804 197.44 µM 0.221686999434115 0.422032965596805 no 1390 0.412278775632752 2038 776813
SGTC_2052 5265182 7.135 µM 0.221363344601992 0.422155503999261 no 1391 0.412404765612338 1998 1239884
SGTC_1526 st051518 75 µM 0.219853482334296 0.422727249762195 no 1392 0.412992632800897 1865 673993
SGTC_1109 tnp00067 928.257 nM 0.218613568502639 0.423196894853972 no 1393 0.413475541159576 1892 676295
SGTC_375 3970-0961 9.27 µM 0.218564168311817 0.423215608546455 no 1394 0.413494783733324 1937 2898222
SGTC_2644 guaiazulene 100 µM 0.217483486125149 0.423625033926028 no 1395 0.413915787592724 2024 3515 A coloring agent.
SGTC_735 3076-0345 636 µM 0.217397561620474 0.423657590679892 no 1396 0.413949265653895 1999 2888990
SGTC_1260 0700-1617 7.75 µM 0.217309023960289 0.423691138102295 no 1397 0.413983762511634 1924 2853078
SGTC_626 0214-0009 33 µM 0.216848173964917 0.423865765710179 no 1398 0.414163333839674 1982 3437874
SGTC_2592 piperlongumine 83.33 µM 0.214692536268086 0.424682788824023 no 1399 0.415003521047014 1867 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2892 9047358 58.44 µM 0.214022822780899 0.424936687620225 no 1400 0.415264629756342 1913 6466771
SGTC_2128 5255449 168.493 µM 0.211856817334055 0.425758066676963 no 1401 0.416109370306479 1933 736008
SGTC_155 k072-0202 43.6 µM 0.209928877900755 0.426489439023281 no 1402 0.41686159154635 2050 5857737
SGTC_581 0958-0271 211 µM 0.209726482983979 0.426566233138618 no 1403 0.416940577375598 1890 4591145
SGTC_1034 k072-0165 12.7 µM 0.20824910135304 0.427126875907678 no 1404 0.417517235775236 2050 5835461
SGTC_1425 4048-4433 7.33 µM 0.207977256718476 0.427230052682146 no 1405 0.417623362789319 2016 23734946
SGTC_1016 4226-1401 38 µM 0.207806987038575 0.427294679912163 no 1406 0.417689838420423 2048 2901613
SGTC_3218 9131285 49.47 µM 0.206040307770296 0.427965352116105 no 1407 0.418379712845388 2039 17156417
SGTC_1222 0366-0074 1.18 µM 0.205557971058035 0.428148494513773 no 1408 0.418568105289907 2053 286520
SGTC_522 1273-0010 11.6 µM 0.205461389248144 0.42818516831758 no 1409 0.41860583073384 1950 5705015
SGTC_3271 9137798 49.47 µM 0.204973241274682 0.428370536131637 no 1410 0.418796515756017 2040 6498326
SGTC_2167 5876490 200 µM 0.20469342835357 0.428476798561131 no 1411 0.418905827556894 2049 686534
SGTC_2776 terbinafine 19.92 µM 0.204475719654978 0.428559479728749 no 1412 0.418990882034582 2033 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2497 7-hydroxyflavone 100 µM 0.204390250675975 0.428591939899966 no 1413 0.41902427410754 2038 5281894
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.204020417016417 0.428732404190887 no 1414 0.419168771995022 1974 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1221 2958-7315 257 µM 0.20391124844505 0.428773868573786 no 1415 0.41921142738529 1972 4562705
SGTC_2607 solasodine 47.35 µM 0.203446350918551 0.42895045464745 no 1416 0.419393087227528 1904 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3275 9138069 49.47 µM 0.203178353145212 0.429052257038809 no 1417 0.419497815821007 1967 17617007
SGTC_591 4299-0174 154 µM 0.202557804125824 0.429287998647662 no 1418 0.419740336825742 1980 5509088
SGTC_3337 9144342 33.5465 µM 0.202276645776778 0.429394816763092 no 1419 0.419850228283118 2001 17682949
SGTC_133 0724-0033 378.92 µM 0.200180899464825 0.430191198323068 no 1420 0.420669552426876 2062 280309
SGTC_642 0335-0876 158 µM 0.19906729065872 0.430614484367949 no 1421 0.421105053702263 1949 6812350
SGTC_2296 7971656 126.45 µM 0.19486404804176 0.43221286394355 no 1422 0.422749690060299 1930 666570
SGTC_1794 st048918 76.9 µM 0.194552636896143 0.432331329677614 no 1423 0.422871592352995 2064 672303
SGTC_2015 5119600 184 µM 0.194146112159829 0.432485987282005 no 1424 0.423030738095126 2041 2828786
SGTC_263 alizarin 107.927 µM 0.193710724272732 0.432651637007928 no 1425 0.423201197073502 1986 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_10 0279-0212 42.575 µM 0.193630232205376 0.432682262696268 no 1426 0.423232712147685 2016 39851 YBR002C RER2
SGTC_2210 7115885 190.385 µM 0.193579049675653 0.432701736877833 no 1427 0.423252751908598 1976 2927039
SGTC_1512 0259-0544 12.2 µM 0.193180657179724 0.432853324805761 no 1428 0.423408743369289 1964 18476
SGTC_2712 st079126 47.7 µM 0.191307472445857 0.433566201738305 no 1429 0.424142353524101 1967 3152970
SGTC_369 0957-0393 4.5 µM 0.191064778361697 0.43365857956642 no 1430 0.424237421021142 1896 6997992
SGTC_1507 4075-3230 155 µM 0.190460505344418 0.433888602674617 no 1431 0.424474144421045 2098 659771
SGTC_2626 ethyl orsellinate 100 µM 0.19032369923485 0.433940682521997 no 1432 0.424527741874378 1956 75653 A natural product.
SGTC_542 3381-0244 89.3 µM 0.189919093924906 0.434094715850656 no 1433 0.424686264992143 2068 1112843
SGTC_1082 camptothecin 424.86 nM 0.189548238252266 0.43423590947591 no 1434 0.424831575806215 1752 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.18886541318069 0.434495899245722 no 1435 0.425099150978737 2056 6728940
SGTC_86 0417-1630 471.922 µM 0.188502357796323 0.434634146319802 no 1436 0.425241433697269 2077 3634867
SGTC_3241 9133421 49.47 µM 0.188022148182568 0.434817016574571 no 1437 0.425429644537211 2070 17018221
SGTC_1998 st075797 76.8 µM 0.187951910518993 0.434843765187844 no 1438 0.425457174544676 2082 24208315
SGTC_1971 st069429 63.5 µM 0.187459674204592 0.435031231932025 no 1439 0.425650119248624 2080 1246522 YGL099W LSG1
SGTC_2702 st077768 96.8 µM 0.186760596422427 0.435297498728012 no 1440 0.42592417138257 1937 6484119
SGTC_3046 9092212 49.47 µM 0.186153218731581 0.435528862348123 no 1441 0.426162304345576 2035 25236637
SGTC_1036 k216-0215 33.5 µM 0.185809523316896 0.43565979332963 no 1442 0.426297068031454 1917 622330
SGTC_2200 6600604 21.907 µM 0.185742072720797 0.435685489504396 no 1443 0.426323516561008 2003 2904777
SGTC_2584 androsterone 48.74 µM 0.18570111725427 0.435701092150234 no 1444 0.426339576059894 2078 2754130 A steroid.
SGTC_1849 st056239 19.2 µM 0.185346102283073 0.435836345023474 no 1445 0.426478790004243 1869 5393181
SGTC_576 1073-0113 22.7 µM 0.18500983933652 0.435964460709837 no 1446 0.426610659063476 2096 5439563
SGTC_1126 isoteolin 1.0172 µM 0.183482720105127 0.436546375241378 no 1447 0.427209637987013 1932 133323
SGTC_2473 5854593 8.94 µM 0.182179167373935 0.43704320762772 no 1448 0.42772106071649 1942 2872951
SGTC_3189 9110682 49.47 µM 0.180588709918902 0.43764952449219 no 1449 0.428345209178318 1950 17122418
SGTC_118 0083-0097 135.343 µM 0.18058783483306 0.437649858134322 no 1450 0.428345552640631 1955 5207356
SGTC_564 3555-0129 330 µM 0.179630859634349 0.438014748529728 no 1451 0.428721188125057 2101 563260
SGTC_1681 tripelennamine 100 µM 0.178543460824641 0.438429432828269 no 1452 0.429148096334403 2113 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2821 7996764 71.43 µM 0.178085303280105 0.438604173484508 no 1453 0.429327991911906 1998 2987135
SGTC_3088 9117578 49.47 µM 0.177754472881183 0.438730359186291 no 1454 0.42945790160924 2099 678341
SGTC_983 1491-0821 12.2 µM 0.176077304392321 0.439370162226749 no 1455 0.430116605409267 2086 46495113
SGTC_1101 ebselen 5.29 µM 0.175605303969068 0.439550248685124 no 1456 0.430302017572805 2116 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2413 inermin 26.06 µM 0.175471003567636 0.439601491782167 no 1457 0.4303547765392 2104 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1885 st057546 99.9 µM 0.175404473864607 0.439626876951077 no 1458 0.430380912724825 2077 702008
SGTC_1093 fluphenazine 7.97 µM 0.175305866092126 0.439664502330773 no 1459 0.430419651337087 1991 6602611 An atypical antipsychotic.
SGTC_3138 9097216 49.47 µM 0.17252859410981 0.440724437662292 no 1460 0.431510991772812 2163 25237486
SGTC_2834 9001755 58.44 µM 0.172127171133601 0.440877674537732 no 1461 0.43166877603734 1952 2989575
SGTC_1448 4255-0083 152 µM 0.171108968491909 0.441266396954796 no 1462 0.432069042018836 2082 5399660
SGTC_539 4859-0462 2.54 µM 0.170972486969123 0.44131850624302 no 1463 0.432122699625494 2133 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2377 9073351 62.6 µM 0.170023695130317 0.441680787464701 no 1464 0.432495750967934 1916 7337946 YHR072W ERG7
SGTC_2426 5582046 32.21 µM 0.168342970947491 0.442322665113049 no 1465 0.433156735139318 2052 2251934
SGTC_3184 9108758 49.47 µM 0.167812173297169 0.442525411151888 no 1466 0.433365522703567 2046 902885
SGTC_1374 2889-5571 141 µM 0.167494691052239 0.442646685404385 no 1467 0.433490412225422 1985 2853281
SGTC_2508 celastrol 40.54 µM 0.167266782185189 0.442733747059614 no 1468 0.433580069931375 2118 122724 Celastrol is a natural product and antioxidant.
SGTC_3087 9117406 49.47 µM 0.1645320302257 0.443778642412732 no 1469 0.434656166922142 2001 42546093
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.162111964959477 0.444703628450957 no 1470 0.435608842077397 2109 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1977 st070720 65.3 µM 0.1606707338129 0.445254632513496 no 1471 0.436176370475533 1975 682188
SGTC_1924 st058459 75.1 µM 0.160502872489087 0.445318815287277 no 1472 0.436242479521484 2088 688683
SGTC_2670 beta-carotene 100 µM 0.158971509655207 0.445904406932175 no 1473 0.436845660176439 2106 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_334 1502-1024 68.5 µM 0.157566384139477 0.446441829412957 no 1474 0.437399247092439 2032 3296216
SGTC_648 0375-0473 33.3 µM 0.155601719106564 0.447193425365003 no 1475 0.438173484899263 2023 1713139
SGTC_1900 st060200 72.8 µM 0.154569256799765 0.447588477038103 no 1476 0.438580454091 1989 688945
SGTC_1028 k015-0029 4.8 µM 0.15427466775942 0.447701205371657 no 1477 0.438696585187308 2126 4588309
SGTC_759 3486-0358 89.3 µM 0.154159089124008 0.447745434196308 no 1478 0.43874214933479 2167 875103
SGTC_1351 1496-0003 46.5 µM 0.150222456172626 0.449252261735987 no 1479 0.440294554732444 2134 3891978
SGTC_984 1492-0255 2.91 µM 0.149903031646492 0.449374560474718 no 1480 0.440420559919103 2052 1585198
SGTC_2024 5144227 134 µM 0.149820426015321 0.449406188649264 no 1481 0.440453146808763 2096 3475211
SGTC_331 k048-0133 24.5 µM 0.149238815035633 0.449628885867752 no 1482 0.440682596479026 2015 6813582
SGTC_3015 9080845 49.47 µM 0.148808592757023 0.449793626988247 no 1483 0.440852335048918 2129 5296973
SGTC_21 0849-0113 22.993 µM 0.148596364828497 0.449874896695589 no 1484 0.440936070805288 2059 1560156
SGTC_2137 5261020 140 µM 0.147820780743128 0.450171913592972 no 1485 0.44124210442241 2059 763655
SGTC_1661 st013063 9.66 µM 0.147794313010704 0.450182050142487 no 1486 0.441252548804952 2087 721395
SGTC_492 tmb-8 126 µM 0.145966829398845 0.450882013722664 no 1487 0.441973787110545 2142 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2060 5238662 140 µM 0.14535657316786 0.451115788468569 no 1488 0.44221467501674 2030 790130
SGTC_741 4582-0002 126 µM 0.143472139479849 0.451837777170702 no 1489 0.442958656534454 2032 2912688
SGTC_1478 0453-0656 35.7 µM 0.142912238751117 0.452052324416163 no 1490 0.443179746333692 2128 5258496
SGTC_338 4055-0136 114 µM 0.142720066427247 0.452125965777371 no 1491 0.443255634118101 2120 2900563
SGTC_3290 9121031 71.43 µM 0.141920319839884 0.452432450188254 no 1492 0.443571471931689 2027 17014854
SGTC_945 3381-0768 11.3 µM 0.14061383380456 0.452933191684101 no 1493 0.44408750951561 2155 1126236 YIL048W NEO1
SGTC_1287 0971-0001 34.6 µM 0.140197666823556 0.453092713223916 no 1494 0.444251907652328 2074 4665869
SGTC_1720 st037298 9.481 µM 0.138801007766053 0.453628123720866 no 1495 0.444803698806442 2046 597396
SGTC_2948 9070189 9.45 µM 0.136370366243225 0.454560112757178 no 1496 0.445764249555898 2186 6473636 YDL196W YDL196W
SGTC_1120 ficusin 1.78878 µM 0.135939919159017 0.454725186752657 no 1497 0.44593438872553 2097 6199 A DNA cross-linker.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.135588252926057 0.454860054546927 no 1498 0.446073396246888 2204 16623 A steroid.
SGTC_1477 0139-0234 16 µM 0.133511607237058 0.45565657614783 no 1499 0.446894392602087 2175 620880
SGTC_2401 5128683 200 µM 0.13310899005776 0.455811025379832 no 1500 0.447053592689976 2054 708373
SGTC_3039 9090270 49.47 µM 0.132853448175196 0.455909058064361 no 1501 0.447154641713645 2194 17173750
SGTC_1063 disulfiram 1.84 µM 0.132548470554855 0.456026059129928 no 1502 0.447275243619667 2171 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_695 3505-6186 243 µM 0.13056641232147 0.45678654485813 no 1503 0.448059157149997 2123 1819379
SGTC_3198 9112019 49.47 µM 0.129940598191781 0.457026693274826 no 1504 0.448306711925459 2119 45595555
SGTC_2358 9037157 4 µM 0.126919019890437 0.458186405757172 no 1505 0.449502246342037 2108 2388925
SGTC_431 k089-0097 107 µM 0.12616998952102 0.458473946683715 no 1506 0.449798683193916 2186 5499420
SGTC_2464 5717415 7.67 µM 0.126067313362996 0.458513364135777 no 1507 0.449839320578584 2079 5285744
SGTC_3262 9137218 49.47 µM 0.1260238173765 0.4585300623998 no 1508 0.449856535669773 2198 17650664
SGTC_2305 7443522 69.23 µM 0.125622941390643 0.458683963559048 no 1509 0.450015201106859 2107 5415886
SGTC_1328 1441-0025 69.2 µM 0.125289232904297 0.458812083024136 no 1510 0.450147287957262 2162 4562601
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.124804422469036 0.458998222121157 no 1511 0.45033919307319 2168 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2804 7954240 19.48 µM 0.123647792829342 0.459442337071075 no 1512 0.450797074803944 2154 828705
SGTC_767 0929-0023 86 µM 0.123627439818742 0.459450152539404 no 1513 0.450805132657224 2193 1204563
SGTC_1441 4106-0040 13 µM 0.122834236471403 0.459754751381505 no 1514 0.451119181378737 2191 2904180
SGTC_2765 myclobutanil 7.74 µM 0.122616971364531 0.459838187710074 no 1515 0.451205207327149 2087 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.12161246452508 0.460223971451279 no 1516 0.451602970751054 2079 4330530
SGTC_2760 etidronate 98.04 µM 0.12012965943623 0.460793515344317 no 1517 0.452190218842119 2122 3305 A chelator and antioxidant.
SGTC_1683 st010134 710 nM 0.118747409653316 0.461324508512758 no 1518 0.452737737387917 2119 3818134
SGTC_186 3455-3465 67.277 µM 0.118319136148512 0.461489044409384 no 1519 0.452907397723486 2175 755278
SGTC_601 0986-0029 62.9 µM 0.117845191016284 0.461671134304465 no 1520 0.453095160871787 2111 24747981
SGTC_615 k087-0205 167 µM 0.117568020072359 0.461777627209512 no 1521 0.453204972725776 2115 9642773
SGTC_2021 4019055 173 µM 0.117049424836768 0.46197688601659 no 1522 0.453410443637179 2161 44827708 YER133W GLC7
SGTC_801 0866-0028 10.1 µM 0.116357481129815 0.462242765012675 no 1523 0.453684615789743 2135 6849771
SGTC_2365 9042475 200 µM 0.116207890718067 0.462300247269836 no 1524 0.453743891618015 2082 6464479
SGTC_846 0335-0850 148 µM 0.116197319120953 0.462304309587166 no 1525 0.453748080696725 2203 6819598
SGTC_1675 st018485 24.5 µM 0.11554920286201 0.462553366858531 no 1526 0.454004911685011 2067 3323024
SGTC_2337 9009472 200 µM 0.115350216319928 0.462629836097873 no 1527 0.454083768547526 2190 5742383
SGTC_14 0354-0009 295 µM 0.114977348184976 0.462773130623722 no 1528 0.454231538242135 2147 1713507
SGTC_2619 obliquin 87.91 µM 0.114550561650868 0.462937152106891 no 1529 0.454400683869581 2164 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2541 muurolladie-3-one 83.07 µM 0.1143072204705 0.463030675174623 no 1530 0.454497129455406 2162 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_867 0518-0118 155 µM 0.113486623344814 0.463346069465488 no 1531 0.454822383795767 2228 6848158
SGTC_2816 7982706 58.44 µM 0.112921753196255 0.463563189183593 no 1532 0.455046295039214 2101 2981853
SGTC_209 4077-0173 175.592 µM 0.112892165469026 0.463574562148336 no 1533 0.455058023836576 2142 15993494
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.111747353302227 0.464014629139847 no 1534 0.455511865965886 2188 279621
SGTC_113 0099-0221 2.5 µM 0.108570659500181 0.465235982493244 no 1535 0.456771516739983 2205 89219
SGTC_2722 naftopidil 47.16 µM 0.108044122550676 0.465438453748407 no 1536 0.456980346154145 2189 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3269 9137823 49.47 µM 0.107931603666337 0.465481722224896 no 1537 0.457024973724853 2065 17682936
SGTC_2026 5148700 152 µM 0.106050721966116 0.466205064273189 no 1538 0.457771054373137 2144 79838
SGTC_385 1494-0393 12.4 µM 0.105456319079482 0.466433680715982 no 1539 0.458006864491616 2136 3090647
SGTC_2828 7998861 71.43 µM 0.105420182422784 0.466447579784832 no 1540 0.45802120101875 2223 2988188
SGTC_653 0203-0016 55.2 µM 0.104778192871989 0.466694511950106 no 1541 0.458275907176387 2153 295302
SGTC_1207 2099-0101 141 µM 0.103222597817936 0.467292902482252 no 1542 0.458893152621436 2212 5837381
SGTC_515 4092-1064 102 µM 0.102928954681162 0.467405866481908 no 1543 0.45900967861455 2231 717353
SGTC_2665 lovastatin 100 µM 0.102042249035504 0.467746996483324 no 1544 0.459361570103659 2143 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1762 st045503 25.4615 µM 0.099746513897037 0.46863031235799 no 1545 0.460272785951539 2129 4645554
SGTC_2923 7992654 58.14 µM 0.0993617271187432 0.468778379628441 no 1546 0.460425534837909 2138 2985126
SGTC_2289 7946404 165.07 µM 0.0992669215666135 0.468814861793562 no 1547 0.460463170714994 2162 1246120 YPR165W RHO1
SGTC_65 0798-0905 34.986 µM 0.0985028506405089 0.469108893787099 no 1548 0.460766504242942 2228 3602145
SGTC_2921 7974240 10.71 µM 0.0975505453900036 0.469475386228041 no 1549 0.461144598089943 2177 2979074 YDR527W RBA50
SGTC_459 nigericin 15.3 µM 0.0973334190992072 0.469558950403391 no 1550 0.46123080869205 2147 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3024 9090631 49.47 µM 0.0954682959771556 0.470276824704009 no 1551 0.461971435679365 2262 25236383
SGTC_664 1222-0054 14.9 µM 0.0952893996672892 0.470345685896791 no 1552 0.462042481090545 2220 6813991
SGTC_1350 1495-0454 146 µM 0.0942271312419933 0.470754594980741 no 1553 0.462464366518799 2230 1069057
SGTC_56 0957-0365 83.25 µM 0.093178297404904 0.471158362817891 no 1554 0.462880957765208 2244 6752360
SGTC_2788 5282734 71.43 µM 0.0927408883698638 0.471326760239241 no 1555 0.463054706374478 2209 743706
SGTC_1985 st071382 65.5 µM 0.0925622352719851 0.471395541092694 no 1556 0.463125673392509 2245 6123237
SGTC_1274 0865-0114 173 µM 0.0924572487779043 0.471435960944792 no 1557 0.463167378105936 2161 870624
SGTC_1632 st005650 90 µM 0.0879860562493685 0.473157640029167 no 1558 0.464943879329547 2170 2759605
SGTC_3270 9137563 49.47 µM 0.0877940750517485 0.473231575841543 no 1559 0.465020173502993 2226 17015724
SGTC_374 0880-0231 82.3 µM 0.0877688049982347 0.473241307915072 no 1560 0.465030216029384 2230 6833587
SGTC_3134 9127454 49.47 µM 0.0876939386751475 0.473270140736079 no 1561 0.46505996865054 2264 24262820
SGTC_1172 0370-0043 85 µM 0.0868391706635499 0.473599342338043 no 1562 0.465399675762672 2185 376585
SGTC_1300 1094-0077 113 µM 0.0862839535036752 0.473813185912873 no 1563 0.465620347074649 2185 5532636
SGTC_1682 st012968 530 nM 0.0860937000550414 0.473886464345251 no 1564 0.46569596582945 2075 24207270
SGTC_826 1683-5028 118 µM 0.0855117631713938 0.474110609896129 no 1565 0.465927272033851 2175 722377
SGTC_2506 ethyl hematommate 54.16 µM 0.0844738786174117 0.474510393831089 no 1566 0.466339835219059 2067 3940691 An allergen.
SGTC_1746 st038117 42 µM 0.0841130603619092 0.474649383859854 no 1567 0.466483270388341 2168 2898218
SGTC_157 1348-1695 65.819 µM 0.083233440642562 0.47498823318683 no 1568 0.466832961597433 2266 5380510
SGTC_1723 st034307 2.5525 µM 0.083124889328004 0.475030050857122 no 1569 0.466876117754015 2202 867466
SGTC_414 piperonyl butoxide 100 µM 0.0804375637508082 0.476065386903514 no 1570 0.467944626064261 2197 5794 A potent inhibitor of cytochrome P450.
SGTC_2841 9004761 38.96 µM 0.0800927586279237 0.476198240550918 no 1571 0.468081741012196 2149 2991039
SGTC_1227 3909-8010 46.6 µM 0.0800752981903664 0.476204968139845 no 1572 0.468088684417637 2181 15982272
SGTC_3005 9076496 71.4286 µM 0.0799981517183899 0.476234693120455 no 1573 0.468119362987974 2283 21368410
SGTC_2215 7188065 200 µM 0.0799396083682712 0.476257250299183 no 1574 0.468142643845634 2252 940217
SGTC_2677 mitomycin C 100 µM 0.0796409612631967 0.476372322384101 no 1575 0.468261408144134 2256 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_592 k241-0073 46.5 µM 0.0792111701340497 0.476537929190798 no 1576 0.468432330014508 2267 4230158
SGTC_731 3966-0296 387 µM 0.0790710833539235 0.476591908204562 no 1577 0.468488041810159 2248 660956
SGTC_2756 carbadox 75.1 µM 0.076740335277197 0.477490067227542 no 1578 0.46941505811112 2204 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_910 3454-3003 490 µM 0.0766860981326201 0.477510969012507 no 1579 0.469436632027411 2274 820824
SGTC_2775 cyproheptadine 69.59 µM 0.0766359538120638 0.477530293569484 no 1580 0.469456578020373 2285 2913 A selective serotonin reuptake inhibitor.
SGTC_3148 9097893 49.47 µM 0.0752039829135151 0.478082166886321 no 1581 0.47002620771213 2198 17174100
SGTC_1289 0976-0073 69.1 µM 0.0748792455934327 0.478207324659005 no 1582 0.470155394903718 2220 3391136
SGTC_1096 rimcazole 32.2 µM 0.0736639736446104 0.478675724444405 no 1583 0.470638882870339 2218 18528119 A dopamine reuptake inhibitor.
SGTC_813 k007-0158 173 µM 0.0734468356675008 0.478759418611579 no 1584 0.470725274367352 2245 6523916
SGTC_1404 3909-7820 48.3 µM 0.0727079128591201 0.479044237733109 no 1585 0.47101927583349 2269 23741373
SGTC_1851 st056236 18.9 µM 0.0726239552458756 0.479076600025428 no 1586 0.47105268176134 2283 5393171
SGTC_613 3914-0030 117 µM 0.072154759748167 0.479257458603551 no 1587 0.471239373886246 2252 1145395
SGTC_2260 7964312 200 µM 0.0717241674410365 0.479423440750781 no 1588 0.471410711427307 2276 231951
SGTC_726 3448-4391 34.2 µM 0.0710412371863196 0.479686699926927 no 1589 0.471682467926188 2234 1356692
SGTC_1302 1159-0335 255 µM 0.0707483624428134 0.479799601386217 no 1590 0.471799014788994 2242 649284
SGTC_2455 5377712 9.75 µM 0.0692780727062042 0.480366413579532 no 1591 0.47238413962066 2126 2243908
SGTC_2269 7935389 174.42 µM 0.068113971426789 0.480815215110618 no 1592 0.472847454298591 2287 97605
SGTC_1640 st009078 66.4 µM 0.0680759009466398 0.480829893018574 no 1593 0.472862607050948 2285 690618
SGTC_303 1348-1668 34.2 µM 0.0678643231234333 0.48091146640065 no 1594 0.472946819636829 2222 5380509
SGTC_2860 9025725 38.96 µM 0.0678259603072512 0.480926257188964 no 1595 0.472962089003561 2169 40546248
SGTC_1572 epiandrosterone 68.9 µM 0.0675129125105826 0.481046953783538 no 1596 0.473086691391413 2223 441302 A steroid.
SGTC_881 0833-0569 170 µM 0.066077679588814 0.481600334571084 no 1597 0.47365799055713 2128 5418700
SGTC_753 1322-0200 289 µM 0.0653131263448786 0.481895136857819 no 1598 0.473962345674209 2228 5403907
SGTC_2484 5809818 12.04 µM 0.0646280034841768 0.482159320185569 no 1599 0.474235093878517 2241 2870548
SGTC_1587 estradiol valerate 56.1 µM 0.0643264303765114 0.482275609245054 no 1600 0.474355154317462 2296 13791 A steroid.
SGTC_1932 st074806 40.9 µM 0.0640464358700712 0.482383578769462 no 1601 0.474466626101126 2230 17251235
SGTC_1088 bifonazole 369 nM 0.0632806055786826 0.482678899469724 no 1602 0.474771529656283 2286 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_476 mead acid 10 µM 0.0614240327732326 0.483394873169133 no 1603 0.475510756553977 2297 5312531 An omega 9 fatty acid.
SGTC_2388 9080168 200 µM 0.0613612938647455 0.483419068917842 no 1604 0.475535738633339 2300 15943073
SGTC_3354 9151612 71.43 µM 0.0607946334795712 0.483637608664495 no 1605 0.475761382140286 2285 27261949
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0606846145653 0.483680039422579 no 1606 0.475805192447501 2144 688788
SGTC_443 clozapine 122 µM 0.0603430606115592 0.483811766976826 no 1607 0.475941203500798 2303 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2585 alliin 100 µM 0.0602337308170842 0.483853932713792 no 1608 0.475984740584445 2255 87310 A garlic compound which reacts with lipids.
SGTC_2135 5326629 150.42 µM 0.0599410658305482 0.483966807085447 no 1609 0.476101286436996 2242 5020077
SGTC_2227 7312221 64.1025 µM 0.05949246813353 0.484139823724071 no 1610 0.476279932205936 2276 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2534 helenine 20.12 µM 0.0592752954088703 0.484223584691245 no 1611 0.476366418957858 2260 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2896 9052656 71.43 µM 0.0592261426161394 0.484242542442389 no 1612 0.476385993694899 2289 6469436
SGTC_1797 st048695 56.8 µM 0.0591122786404402 0.484286458800296 no 1613 0.476431339401922 2306 592262 YIL048W NEO1
SGTC_3212 9128307 49.47 µM 0.0578872685008725 0.48475894664181 no 1614 0.47691921219057 2075 27243542
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0571080816920309 0.485059491080852 no 1615 0.477229549336289 2253 6708739 YPR165W RHO1
SGTC_1469 k284-2957 126 µM 0.0567370929173509 0.485202590199137 no 1616 0.47737731285892 2262 23884841
SGTC_756 0508-1999 28.3 µM 0.0564365714219675 0.485318509824115 no 1617 0.477497011793496 2249 6753853
SGTC_2414 st077232 92.9 µM 0.0558061199241169 0.485561696785383 no 1618 0.477748129774748 2116 729801
SGTC_1757 st041620 31.8375 µM 0.0556384404390907 0.485626377473538 no 1619 0.477814920438684 2241 5289815
SGTC_1855 st056195 39.6 µM 0.0544120638612718 0.4860994513893 no 1620 0.47830343376158 2325 4028379
SGTC_2179 6298986 200 µM 0.0543903920860226 0.486107811439465 no 1621 0.478312066764903 2317 738374
SGTC_2803 7707263 71.43 µM 0.0542376493165591 0.486166733283588 no 1622 0.478372912499538 2271 2199229
SGTC_46 0329-0187a 2.197 µM 0.0528213911929142 0.486713081314806 no 1623 0.478937108791894 2255 46494817
SGTC_839 0122-0028 230 µM 0.0527505840966039 0.486740397138218 no 1624 0.478965317409282 2245 759448
SGTC_2465 5809242 33.21 µM 0.0504737258268943 0.487618791531074 no 1625 0.479872443231425 2323 2731748
SGTC_2180 6301957 200 µM 0.0490858538939734 0.4881542515766 no 1626 0.480425438387685 2316 845462
SGTC_802 4112-3352 742 µM 0.0485903185358429 0.488345441144158 no 1627 0.480622892770972 2285 704594
SGTC_314 1671-0008 2.74 µM 0.048468114444598 0.488392590861776 no 1628 0.48067158777557 2271 3913060
SGTC_1558 st069300 45.6 µM 0.0484639632176556 0.488394192522774 no 1629 0.480673241931601 2322 24208000
SGTC_2213 7173844 200 µM 0.0476629882093783 0.488703234851432 no 1630 0.480992415844971 2311 892728
SGTC_986 1493-0483 84 µM 0.0469716363887762 0.488969986433238 no 1631 0.481267916725345 2323 40079
SGTC_1262 0737-0114 49.6 µM 0.0468319136464653 0.48902389773923 no 1632 0.481323596759234 2319 765919
SGTC_1053 3366-3204 134 µM 0.0445601147182524 0.489900487180552 no 1633 0.482228967452236 2281 3632071 YPR165W RHO1
SGTC_2734 clemastine 41.6 µM 0.0439782165868424 0.49012502464493 no 1634 0.482460883854966 2331 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_946 3434-1334 87.4 µM 0.0430228285621921 0.490493687686102 no 1635 0.482841668069108 2302 4047976
SGTC_2957 9076800 11.52 µM 0.042670792793199 0.490629532542891 no 1636 0.482981981164877 2295 16459615
SGTC_193 1273-0060 1.558 µM 0.0421474440661861 0.490831486278013 no 1637 0.483190579427265 2329 2847393 YHR072W ERG7
SGTC_2809 7964133 12.99 µM 0.0418316494028648 0.490953348633435 no 1638 0.483316452256361 2282 1253665
SGTC_2300 7976697 71.57 µM 0.0412130647175177 0.491192057405233 no 1639 0.483563019192001 2292 2236109
SGTC_2723 salbutamol 83.58 µM 0.0404606349461425 0.491482420577929 no 1640 0.483862945044055 2323 9884233 β2-adrenoceptor agonist
SGTC_2646 retinol 96.75 µM 0.0403797674327694 0.491513627678987 no 1641 0.483895180170726 2310 445354 A vitamin A analog and teratogen.
SGTC_1396 3511-0007 98.6 µM 0.0401304679673472 0.491609833678836 no 1642 0.48399455571731 2298 X1396
SGTC_1641 st009299 47.1 µM 0.040106466805036 0.491619095881853 no 1643 0.48400412309333 2342 4046054
SGTC_1301 naphtanilide LB 4.81 µM 0.039371919394059 0.491902564617207 no 1644 0.484296933810797 2332 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2744 captopril 92.04 µM 0.038231255134769 0.492342765706996 no 1645 0.484751650555673 2333 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3037 9091026 49.47 µM 0.0366579568415206 0.492949942573339 no 1646 0.485378865836917 2341 25236398 YIL048W NEO1
SGTC_355 1311-2252 105 µM 0.0366442332306398 0.4929552389468 no 1647 0.485384337089528 2298 5338538
SGTC_3057 9095946 49.47 µM 0.0355381376339682 0.493382120060127 no 1648 0.48582531806809 2347 24540043
SGTC_1269 0831-0796 3.05 µM 0.0354608217237756 0.493411959272621 no 1649 0.485856143224353 2349 927758
SGTC_819 1013-0258 27.7 µM 0.0354519035579658 0.49341540114154 no 1650 0.485859698822089 2315 5753198
SGTC_1891 st059073 26.2 µM 0.0353427440824668 0.493457530091316 no 1651 0.485903219878307 2348 688754
SGTC_646 4092-0839 27.3 µM 0.0352557949764608 0.493491087235165 no 1652 0.485937885948568 2318 877796
SGTC_2967 9089538 49.85 µM 0.033578629316548 0.494138381393275 no 1653 0.4866065819958 2350 728216
SGTC_473 2-arachidonoylglycerol 10 µM 0.0330308501376759 0.494349797604373 no 1654 0.486824993102829 2310 5282280 An endocannabinoid.
SGTC_2176 5809774 33.9695 µM 0.0306645812567658 0.495263080174528 no 1655 0.487768518966567 2351 2870539
SGTC_814 3342-0569 96 µM 0.0306464452669843 0.495270080023457 no 1656 0.487775750780802 2352 4346283
SGTC_1185 1319-0113 81.3 µM 0.0305618280662801 0.495302739281501 no 1657 0.4878094923547 2314 4672763
SGTC_1204 4049-0315 18.3 µM 0.0305266759856049 0.495316306755352 no 1658 0.487823509465758 2323 588402
SGTC_2575 plumbagin 510 nM 0.0293609882257684 0.495766224439144 no 1659 0.488288343133256 2341 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1523 st012844 44.7 µM 0.0293461299455333 0.495771959289585 no 1660 0.488294268176304 2245 4274103
SGTC_1297 1068-0111 14.1 µM 0.0286868623371134 0.496026417671485 no 1661 0.488557167196502 2328 767057
SGTC_479 n-linoleoylglycine 10 µM 0.0276064053019326 0.49644344653608 no 1662 0.488988036460812 2354 6433346 An anti-infammatory.
SGTC_2447 5741742 33.78 µM 0.0274188881841381 0.496515823770562 no 1663 0.489062816659657 2327 1776504
SGTC_1783 st039459 87.517 µM 0.0268891307493365 0.496720298398039 no 1664 0.489274081394933 2345 729761
SGTC_1978 st071761 42 µM 0.0263975920136585 0.496910022226568 no 1665 0.489470107388369 2228 5147680
SGTC_2970 9090938 41.86 µM 0.0257056858465431 0.497177084931363 no 1666 0.489746044353572 2360 17217104
SGTC_162 k030-0015 37.8 µM 0.0253828821880608 0.497301681483231 no 1667 0.489874782372347 2360 1809920 YMR134W ERG29
SGTC_1920 st075728 45.7 µM 0.0253075261181915 0.497330767643186 no 1668 0.489904835440409 2358 3400306
SGTC_3310 9130229 44.1445 µM 0.0249426209381557 0.497471615027706 no 1669 0.490050365602643 2340 7761258
SGTC_2153 5569715 200 µM 0.0241726547413401 0.497768810300596 no 1670 0.490357445055121 2367 2054701
SGTC_553 k007-0256 45.7 µM 0.0236449593381106 0.497972493447115 no 1671 0.490567904898913 2333 6287000
SGTC_3295 9122362 53.5725 µM 0.0226013876921444 0.498375299212395 no 1672 0.490984118446591 2318 4730473
SGTC_3135 9127742 49.47 µM 0.0222791098369837 0.498499694837614 no 1673 0.491112656340844 2302 3643468
SGTC_2037 5169046 200 µM 0.0192932970492639 0.499652190323596 no 1674 0.492303565557313 2350 5718022
SGTC_251 melphalan 456.522 µM 0.0189314405249766 0.499791863906921 no 1675 0.492447899059834 2322 460612 A DNA alkylator.
SGTC_514 4466-0038 2.65 nM 0.0186331085821469 0.499907017554553 no 1676 0.492566895293752 2293 5722064
SGTC_1264 0783-0040 158 µM 0.0183922162409229 0.5 no 1677 0.492662980966871 2358 2855798
SGTC_3321 9137793 26.8275 µM 0.0182099460725334 0.499929645226709 no 1678 0.492735684067168 2376 4904192
SGTC_228 caffeine 993.056 µM 0.0174270063331822 0.499627437033064 no 1679 0.493047982243253 2367 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1805 st050013 60.3 µM 0.017336744041723 0.499592596553653 no 1680 0.493083986248282 2353 4037144
SGTC_863 0466-0191 129 µM 0.0154597710279169 0.49886810198157 no 1681 0.493832689361804 2379 765160 YPR165W RHO1
SGTC_2183 6420625 130.508 µM 0.0149613692168388 0.49867572392851 no 1682 0.494031499914936 2375 2897619
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0124601625905561 0.497710289049349 no 1683 0.495029242945305 2372 165506
SGTC_2346 9031566 143.75 µM 0.0118948991905406 0.497492106010988 no 1684 0.495254733692247 2380 4771086
SGTC_3010 9080089 71.4286 µM 0.0113569721989631 0.49728447510436 no 1685 0.495469321007813 2387 17027233
SGTC_916 4466-0038 42 nM 0.0110008308785278 0.49714701085628 no 1686 0.495611391960154 2384 5722064 YGL116W CDC20
SGTC_1954 st077032 68.9 µM 0.0107803324042443 0.497061902515483 no 1687 0.495699352907683 2305 698907
SGTC_2701 st077767 14.721 µM 0.0106649905392406 0.497017382737762 no 1688 0.495745365009101 2375 5721188
SGTC_1728 st035614 33.7865 µM 0.0100145097899959 0.496766310186588 no 1689 0.496004855406501 2332 15945546
SGTC_3228 9131799 49.47 µM 0.0100053440230484 0.496762772392898 no 1690 0.496008511835279 2374 17015818
SGTC_145 3737-0113 38.366 µM 0.00860070551335398 0.496220614581604 no 1691 0.496568857230986 2389 6849351
SGTC_2480 5767542 37.17 µM 0.00836390311350245 0.496129215020425 no 1692 0.496663324321677 2384 2867358
SGTC_1931 st074438 57.1 µM 0.0080737906890293 0.49601723945511 no 1693 0.496779058524506 2395 2787313
SGTC_472 calcifediol 10 µM 0.00779325703650852 0.495908961335552 no 1694 0.496890971737196 2372 5283731 A vitamin D metabolite.
SGTC_804 1595-0054 20.9 µM 0.00757950443255054 0.495826459029094 no 1695 0.496976244169295 2384 761523 Stimulates phospholipase C.
SGTC_237 nikkomycin 200 µM 0.00744276692448006 0.495773682409662 no 1696 0.497030793003771 2391 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_147 4466-0538 29.23 µM 0.00667493235992868 0.495477322459158 no 1697 0.497337107036895 2366 6742687 YHR072W ERG7
SGTC_3232 9132874 49.47 µM 0.00484376939247544 0.494770561625397 no 1698 0.498067623149101 2397 3784940
SGTC_776 4476-4378 112 µM 0.00366942417572989 0.494317316526004 no 1699 0.498536114836698 2370 2892008
SGTC_893 0958-0369 48.9 µM 0.00321839600271751 0.494143241599857 no 1700 0.498716047975986 2400 6819948
SGTC_465 cgp-37157 41 µM 0.00231801078018023 0.493795740088229 no 1701 0.499075248321502 2398 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_43 0570-0105 72.5 µM 0.00222449096895717 0.493759646607348 no 1702 0.49911255723201 2402 1114046 YDL195W SEC31
SGTC_2309 7664088 163.95 µM 0.00198565682456539 0.493667470053893 no 1703 0.499207838058874 2401 704922
SGTC_897 1000-0139 31.4 µM 0.0017103811206424 0.493561229526806 no 1704 0.499317656988064 2385 6151020
SGTC_1692 fluoroquinolonic acid 71 µM 0.00122408969942247 0.493373550237784 no 1705 0.499511658985851 2397 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1044 1222-0021 1.78 µM 0.000753010877037948 0.493191743496739 no 1706 0.499699592151937 2401 4306703
SGTC_1174 0739-0097 51.1 µM 0.000744473027233351 0.49318844843765 no 1707 0.499702998260253 2402 728447
SGTC_1857 st056007 79.3 µM 0 0.492901131700877 no 1708 0.5 2405 619834
SGTC_2750 bromebric acid 70.15 µM -0.000504410450387244 0.492706465127416 no 1709 0.499798769353197 2407 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2985 9022375 71.43 µM -0.00116218414862913 0.492452613859934 no 1710 0.499536355709871 2415 4939335
SGTC_2459 5811157 9.22 µM -0.00152988617992579 0.492310709805104 no 1711 0.499389663956713 2407 2870684 YBR192W RIM2
SGTC_1820 st053765 18.6 µM -0.00194102713612465 0.492152042896026 no 1712 0.499225642694236 2412 3690829
SGTC_949 1165-0505 146 µM -0.00208511210018393 0.492096438132573 no 1713 0.499168161226623 2402 6244267
SGTC_2835 9006588 71.43 µM -0.00226381527822035 0.492027473843009 no 1714 0.499096869141902 2417 2345538
SGTC_2963 9082507 9 µM -0.00346991850631814 0.491562026495785 no 1715 0.498615705576178 2418 16459611
SGTC_1024 4507-0395 26 µM -0.0038645560583803 0.491409734365291 no 1716 0.498458269030904 2442 4201836
SGTC_2618 avocadyne 43.43 µM -0.00401408217459243 0.491352031994932 no 1717 0.498398617204026 2413 3015189
SGTC_1830 st055982 50.3 µM -0.00476156114816705 0.491063581386437 no 1718 0.498100419115312 2411 455313 An antimicrobial agent.
SGTC_249 wiskostatin 11.211 µM -0.00590801946572135 0.490621174597235 no 1719 0.497643054953105 2415 2775510 A n-wasp and actin depolymerizer.
SGTC_3243 9134147 49.47 µM -0.00685294657257434 0.490256545334781 no 1720 0.497266091265588 2419 24282180
SGTC_181 1447-1644 8.07 µM -0.00694635008953631 0.490220503144765 no 1721 0.497228829540483 2415 534600
SGTC_1162 k048-0130 20.1 µM -0.00761053972231256 0.489964210523 no 1722 0.496963863237123 2419 6797406
SGTC_3209 9113616 49.47 µM -0.00798522030577161 0.489819633350079 no 1723 0.496814391856127 2423 16649353
SGTC_2827 7993847 71.43 µM -0.00842037203262554 0.489651723990143 no 1724 0.496640797275594 2432 2985692
SGTC_682 0kpi-0099 17 µM -0.00863278892049809 0.489569760637085 no 1725 0.496556058278537 2434 1714895 YML126C ERG13
SGTC_641 4092-0595 30 µM -0.0087439672740624 0.489526861442567 no 1726 0.496511706206712 2427 786260
SGTC_3329 9141233 27.5565 µM -0.00879313928060513 0.489507888008324 no 1727 0.496492090168421 2421 4909101 YNL103W MET4
SGTC_254 nsc-64875 3.808 µM -0.00920425523827984 0.489349256375225 no 1728 0.496328085272321 2422 56993
SGTC_1153 4055-0057 267 µM -0.0101136047774625 0.488998384256119 no 1729 0.495965324228254 2420 882706
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.011530644291438 0.48845163725591 no 1730 0.495400040403954 2426 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1967 st070177 51.4 µM -0.0116314137720934 0.488412757424634 no 1731 0.495359841893371 2428 5729214
SGTC_2277 7947813 106.88 µM -0.0124354418698936 0.488102543697228 no 1732 0.49503910432195 2451 1246798
SGTC_1356 1502-0781 85.8 µM -0.0132150700174371 0.487801750939796 no 1733 0.494728103277675 2429 567702
SGTC_139 0099-0334 718.624 µM -0.0134451745329641 0.487712974330066 no 1734 0.49463631301329 2436 97690
SGTC_1006 4099-6547 255 µM -0.0154077151212452 0.486955831848478 no 1735 0.493853454190675 2446 3146833
SGTC_618 k072-0232 33.2 µM -0.0154451028439694 0.486941408220916 no 1736 0.493838540421964 2440 5872756 YGL099W LSG1
SGTC_2469 5655019 90.81 µM -0.0162930600462402 0.486614283563004 no 1737 0.493500297044355 2439 2788239
SGTC_2943 9068529 45.32 µM -0.0168254862316954 0.486408888948786 no 1738 0.49328791885035 2430 3270634
SGTC_3199 9111318 49.47 µM -0.0169280447894216 0.486369325237644 no 1739 0.493247009731863 2451 8548020
SGTC_1694 st024011 44.9 µM -0.017017615022485 0.486334772103787 no 1740 0.493211281525448 2434 2787533
SGTC_2436 5633522 8.09 µM -0.0189036059046213 0.48560724552079 no 1741 0.492459001479949 2446 5724242
SGTC_1919 st067113 52.3 µM -0.0226789914517274 0.484151025690137 no 1742 0.490953166959329 2466 1268243
SGTC_387 norethindrone acetate 66.7 µM -0.023315525789815 0.483905525647271 no 1743 0.490699293645585 2467 541197
SGTC_1275 0867-0008 21.1 µM -0.0246144025387306 0.483404590871359 no 1744 0.490181265607981 2452 3422836
SGTC_123 0083-0120 66.675 µM -0.0246955269187682 0.48337330468124 no 1745 0.490148911497819 2457 16001701
SGTC_399 oxolinic acid 75 µM -0.0262722909300726 0.482765235070999 no 1746 0.489520077957332 2471 4628 A DNA gyrase inhibitor.
SGTC_3331 9141060 1.957 µM -0.0278007089744149 0.482175848042164 no 1747 0.488910550251281 2463 4906567 YPR165W RHO1
SGTC_2315 7733312 200 µM -0.0297964412173669 0.481406314617843 no 1748 0.488114698502644 2465 726316
SGTC_1201 1889-3372 45.9 µM -0.0315019821940011 0.480748730692361 no 1749 0.487434605684342 2509 5392199
SGTC_2130 NSC 7 2.4545 µM -0.0317383423828859 0.480657604367297 no 1750 0.487340358739271 2483 21448
SGTC_2560 caryophyllene 100 µM -0.0320487063548643 0.480537948153891 no 1751 0.487216604386313 2474 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_320 4092-0846 5.34 µM -0.0321364719270367 0.480504111760447 no 1752 0.487181609014928 2524 1359356
SGTC_718 1130-0073 349 µM -0.0328708597717345 0.480220987635507 no 1753 0.486888785383274 2502 6740020
SGTC_82 0054-0107 293.755 µM -0.0354332235245517 0.479233214030497 no 1754 0.485867146398017 2564 3104697
SGTC_1367 1812-0510 76.9 µM -0.03560722264898 0.479166143120277 no 1755 0.485797774567167 2488 1142582 YDR527W RBA50
SGTC_1131 3454-3128 32.3 µM -0.035767793696247 0.47910424881324 no 1756 0.485733756766934 2598 710982
SGTC_1337 1486-1011 40.3 µM -0.0360435404171612 0.478997959643496 no 1757 0.485623820630236 2478 X1337
SGTC_1785 bathophenanthroline 24 µM -0.0374104294688179 0.47847110158774 no 1758 0.485078878489713 2481 72812 An iron chelator.
SGTC_3282 9108498 15.4605 µM -0.0377618222659177 0.478335665674085 no 1759 0.484938792032847 2523 16459645
SGTC_862 0452-0056 10.2 µM -0.0378568309544839 0.478299047286055 no 1760 0.48490091613232 2485 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2580 diallyl disulphide 81.36 µM -0.0379596618343494 0.478259414264037 no 1761 0.484859922012209 2496 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2040 5100729 123 µM -0.0382666423907259 0.478141099264731 no 1762 0.484737543406114 2484 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_451 chloral hydrate 100 µM -0.0385727652185596 0.478023116765462 no 1763 0.484615508167315 2521 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1880 MG-132 525 µM -0.0389526221738547 0.477876719147201 no 1764 0.484464080974191 2501 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2220 6782180 200 µM -0.0394008736879056 0.477703965972783 no 1765 0.484285391674846 2483 833803
SGTC_398 bronopol 33.3 µM -0.0412025352645603 0.477009660082535 no 1766 0.483567216270969 2490 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2719 novobiocin 32.65 µM -0.0414788997461853 0.47690316368905 no 1767 0.483457056969178 2489 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_978 1416-0512 87.4 µM -0.0419926888871342 0.476705180659438 no 1768 0.483252263200316 2513 6814003
SGTC_363 0455-0021 3.06 µM -0.0432059910377969 0.476237670847296 no 1769 0.482768664696294 2497 4597466
SGTC_55 0767-0285 6.563 µM -0.0433474260157859 0.476183175211352 no 1770 0.482712293116836 2486 3116166
SGTC_780 0109-0199 192 µM -0.0443861047946387 0.475782980565466 no 1771 0.482298318750472 2484 610414
SGTC_1627 st003713 25.6 µM -0.0446873412879548 0.475666921099916 no 1772 0.482178261903965 2522 16195070 YER133W GLC7
SGTC_2846 9008642 19.48 µM -0.0448716734508571 0.475595903191174 no 1773 0.48210479770295 2562 2992898
SGTC_78 0336-0123 156.75 µM -0.0449942200300721 0.475548689929077 no 1774 0.482055958019028 2500 6765896
SGTC_3170 9103054 49.47 µM -0.0454669553005422 0.47536656343108 no 1775 0.481867556748782 2521 16432970
SGTC_2192 5915882 198.485 µM -0.0458357439947513 0.475224487074488 no 1776 0.481720584575145 2482 2876149
SGTC_1148 3909-7663 27.7 µM -0.0459550448716593 0.475178526919505 no 1777 0.481673040510768 2599 4084526
SGTC_3132 9126706 49.47 µM -0.0468279085017248 0.474842270009267 no 1778 0.481325192829726 2613 850858
SGTC_1569 carminic acid 40.6 µM -0.0493490669424275 0.473871135060403 no 1779 0.480320558679285 2501 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2393 9031399 185.94 µM -0.0535589857008608 0.472249848805221 no 1780 0.478643267125529 2546 1526623 YDL150W RPC53
SGTC_2625 euphol 100 µM -0.0536134535496219 0.472228875588873 no 1781 0.478621568773338 2534 6708538 A triterpene alcohol.
SGTC_1754 st042065 16.137 µM -0.0540600705674236 0.472056905572166 no 1782 0.478443652386341 2542 1126236 YIL048W NEO1
SGTC_968 1309-0633 340 µM -0.0550945184234198 0.47165861117427 no 1783 0.478031581589043 2502 3761976
SGTC_2446 5162541 200 µM -0.0557508243685672 0.471405927770218 no 1784 0.477770155219908 2504 1549321
SGTC_593 1203-0218 61.7 µM -0.0558352811418252 0.471373412023679 no 1785 0.477736514242873 2530 3666956
SGTC_1003 4049-0218 100 µM -0.0571915086077945 0.470851292518336 no 1786 0.477196321119932 2567 295161
SGTC_445 e6 berbamine 66 µM -0.0577938954890876 0.470619402051648 no 1787 0.476956400373603 2562 6610268 A calcium/calmodulin antagonist.
SGTC_2759 disulfiram 3.38 µM -0.0587778572678976 0.470240644753727 no 1788 0.476564522651184 2528 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1421 4029-0249 71.4 µM -0.0599791458727664 0.469778268176188 no 1789 0.476086121982365 2545 2894095
SGTC_1503 4585-0012 61.3 µM -0.0609787423143145 0.469393554046408 no 1790 0.475688069360194 2649 2922052
SGTC_2193 5925765 200 µM -0.0618216060153064 0.469069183748736 no 1791 0.475352448641736 2567 877370
SGTC_1305 1181-0477 144 µM -0.0622252404278895 0.468913855077776 no 1792 0.475191731239603 2565 6252086
SGTC_1235 benzylparaben 21.5 µM -0.0629798757019572 0.468623465160295 no 1793 0.474891264683131 2560 7180
SGTC_2217 6934799 96.0675 µM -0.0634631272593079 0.468437514707334 no 1794 0.47469886010771 2529 675606
SGTC_1433 4060-0023 7.6 µM -0.0635782127947753 0.468393231937261 no 1795 0.474653040153987 2596 3840627
SGTC_2710 st078562 53.7235 µM -0.0639401735541718 0.468253958731861 no 1796 0.474508931918799 2500 17250908
SGTC_2056 5235370 200 µM -0.064083310548544 0.468198884363131 no 1797 0.474451945390819 2565 5511916
SGTC_201 4262-0159 12.803 µM -0.0663737014146361 0.467317701414413 no 1798 0.473540153625943 2559 1341029
SGTC_1619 st003326 88.7 µM -0.0667104935030303 0.467188140668195 no 1799 0.473406090158119 2532 2849032
SGTC_2437 5741531 144.16 µM -0.0680955961704102 0.466655341405212 no 1800 0.472854767984197 2572 2262990
SGTC_1020 4335-0961 93.3 µM -0.068966586496042 0.466320333237973 no 1801 0.472508108130773 2520 669075
SGTC_2801 7907800 81.82 µM -0.0706449831230472 0.465674840664041 no 1802 0.471840154234108 2588 6620925
SGTC_1608 st001473 40.5 µM -0.0714917601607686 0.465349213847783 no 1803 0.471503191109207 2545 7292267
SGTC_3006 9075424 71.4286 µM -0.0731803074952427 0.464699955022485 no 1804 0.470831318353746 2545 7465181
SGTC_2819 7996655 46.38 µM -0.0731863713735841 0.464697623585134 no 1805 0.470828905685836 2573 6456960
SGTC_3205 9113483 49.47 µM -0.0743348741500358 0.464256069672733 no 1806 0.470371964111338 2633 17018033
SGTC_258 haloperidol 50.781 µM -0.0761584826245763 0.463555054962402 no 1807 0.469646506391619 2551 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2814 7977482 42.97 µM -0.0765383917145927 0.463409027991007 no 1808 0.469495385683923 2609 6456762
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0773728367994054 0.463088306780193 no 1809 0.469163474541592 2541 688662
SGTC_650 1328-0195 38 µM -0.0774409686184742 0.463062121189038 no 1810 0.469136375187409 2529 2780821
SGTC_1827 berberine 7.24 µM -0.0782025629009255 0.462769423110975 no 1811 0.468833461681618 2552 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2303 7774051 200 µM -0.0793710026367436 0.462320404271381 no 1812 0.468368766201136 2630 2953184
SGTC_3261 9137475 49.47 µM -0.0795599272516484 0.462247807065515 no 1813 0.468293633781052 2538 17027690
SGTC_3122 9126309 49.47 µM -0.0799405386005654 0.46210155508826 no 1814 0.468142273920519 2534 17591206
SGTC_1281 0884-0031 11.8 µM -0.0806503016064895 0.461828838501797 no 1815 0.467860030783201 2555 1548255
SGTC_1958 st076513 41.9 µM -0.0807130603616028 0.46180472518268 no 1816 0.467835075019844 2556 732122 YGL099W LSG1
SGTC_3030 9087619 49.47 µM -0.0828785248331432 0.460972791841499 no 1817 0.466974064992251 2568 25236973
SGTC_1377 2944-0135 198 µM -0.0832366266177852 0.460835231796144 no 1818 0.466831694972454 2612 1894137
SGTC_1169 aniline yellow 25.8 µM -0.0848591680381818 0.460212013018621 no 1819 0.466186676916355 2603 6051 A DNA damaging agent.
SGTC_2115 tiliquinol 12.7705 µM -0.0856778451991925 0.459897595810366 no 1820 0.465861257162505 2642 71208 A bioactive hydroxyquinoline.
SGTC_2735 sertaconazole 140 nM -0.085975208012574 0.459783398278222 no 1821 0.465743062688347 2553 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2928 9011484 9.79 µM -0.0863804472175809 0.459627777850311 no 1822 0.465581994843399 2638 2994751
SGTC_1353 1498-1206 8.11 µM -0.0868404095513731 0.459451150078973 no 1823 0.465399183378016 2552 6756808
SGTC_748 act1.228 77.9 µM -0.0880291796539797 0.458994693738228 no 1824 0.464926742075784 2557 4421505 YNR035C ARC35
SGTC_426 0988-0037 14.6 µM -0.0884592472123379 0.458829572431814 no 1825 0.464755836665478 2537 5383008
SGTC_3060 1327-0027 12.5 µM -0.0895987871094687 0.458392088808966 no 1826 0.464303024138958 2610 16000455 YPR107C YTH1
SGTC_1596 piperlongumine 63 µM -0.0921303738342475 0.457420362100202 no 1827 0.463297228120598 2647 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1873 rapamycin 2 nM -0.0925906382817226 0.457243720918541 no 1828 0.46311439068342 2591 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3055 9094636 49.47 µM -0.0943296726277328 0.456576387484313 no 1829 0.462423639825266 2670 25236176
SGTC_868 0527-0199 213 µM -0.0949673408908605 0.456331720570062 no 1830 0.462170383919071 2633 2849450
SGTC_1343 1487-0095 224 µM -0.102024125092089 0.4536252292678 no 1831 0.459368762971704 2583 4560101 YGL055W OLE1
SGTC_313 3474-0040 5.03 µM -0.103535169009085 0.453045973493086 no 1832 0.458769119316106 2572 1043375 YIL048W NEO1
SGTC_1118 chelidonine 707.474 nM -0.103650744381847 0.453001671993688 no 1833 0.458723258154291 2595 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2397 5161689 200 µM -0.105628096251426 0.452243819130775 no 1834 0.457938715932729 2710 2259942
SGTC_1621 st003705 32.4 µM -0.106543841505053 0.45189290336229 no 1835 0.457575436424006 2664 24207032
SGTC_397 arbidol 50 µM -0.107109482902937 0.451676166986501 no 1836 0.457351062090115 2740 131410 A RNA synthesis inhibitor.
SGTC_2974 9094440 9.66 µM -0.107149353992809 0.451660890154557 no 1837 0.457335246841019 2812 25236134
SGTC_323 4013-0906 34.3 µM -0.107419203873324 0.451557497540622 no 1838 0.457228210082629 2711 2910086
SGTC_1238 0333-0287 48.8 µM -0.107451353199231 0.451545179789142 no 1839 0.457215458163495 2610 7226
SGTC_2643 anethole 100 µM -0.108313085158374 0.451215031653078 no 1840 0.456873671613415 2604 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3069 9117009 49.47 µM -0.10846261566159 0.451157746715166 no 1841 0.456814366952031 2599 41904981
SGTC_1926 methyl fluorone black 53.6 µM -0.110486941237651 0.450382330850553 no 1842 0.456011602922426 2592 72721 Reacts with homocysteine.
SGTC_1336 1486-0901 104 µM -0.111233846403343 0.450096277248692 no 1843 0.455715456307054 2683 5006114
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.111291659981355 0.450074136584824 no 1844 0.455692534346475 2794 94937 An inhibitor of serotonin biosynthesis.
SGTC_3186 9110464 49.47 µM -0.112730049405034 0.449523331818817 no 1845 0.455122288557428 2716 17018021
SGTC_1384 3089-0840 101 µM -0.112936925955036 0.449444120224086 no 1846 0.455040280458842 2613 1069836
SGTC_2865 9030313 51.95 µM -0.113097237049297 0.44938273960436 no 1847 0.454976732727262 2605 42562754
SGTC_1144 3486-0183 12.5 µM -0.113733039641249 0.449139312642031 no 1848 0.454724710300532 2633 6744069
SGTC_786 4544-0069 423 µM -0.11398930783111 0.449041201766716 no 1849 0.454623134655372 2729 748821 YLR208W SEC13
SGTC_2394 5221648 200 µM -0.11461774207452 0.448800622353628 no 1850 0.454374058124895 2703 788586
SGTC_2789 5281112 71.43 µM -0.115896338103329 0.448311203917877 no 1851 0.453867348955115 2662 765948
SGTC_937 3122-0005 46.7 µM -0.119339133005193 0.446993770877076 no 1852 0.452503340679074 2705 759535
SGTC_3106 9121286 49.47 µM -0.119762668063712 0.446831739432328 no 1853 0.452335577800724 2823 15943471
SGTC_595 3909-8003 73.7 µM -0.121165533496057 0.44629510993631 no 1854 0.451779961612196 2706 699517
SGTC_1898 st060199 18.6 µM -0.121869876942471 0.446025718786434 no 1855 0.451501036241553 2619 688866
SGTC_588 3970-1144 52.9 µM -0.121891983571367 0.446017264038046 no 1856 0.451492282234891 2756 1888707
SGTC_1557 sumaresinolic acid 42.3 µM -0.122256265793238 0.445877946716565 no 1857 0.4513480334737 2607 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_75 0159-0059 199.013 µM -0.122393747387831 0.44582536952772 no 1858 0.451293595072293 2852 5377270
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.122704099097059 0.445706684995853 no 1859 0.451170708894418 2640 65057 A dermal irritant. YDR527W RBA50
SGTC_730 1436-0052 41.2 µM -0.12309076840528 0.44555882193721 no 1860 0.451017610717001 2619 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_244 nsc-207895 1.295 µM -0.123652105129413 0.445344179216867 no 1861 0.450795367546528 2598 42640
SGTC_750 4073-0104 132 µM -0.124536406602304 0.445006074458526 no 1862 0.450445288218704 2680 22330957
SGTC_2248 tofa 1.1 µM -0.124608420252799 0.44497854244156 no 1863 0.450416780980852 2633 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2915 7971052 15.16 µM -0.124994044485933 0.444831116399257 no 1864 0.450264132587677 2613 5741558
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.125671410891536 0.444572174374979 no 1865 0.44999601660779 2668 676296 Flavone; oxidizing agent.
SGTC_1345 1488-0192 31.4 µM -0.125990720466996 0.444450117663759 no 1866 0.449869635017805 2662 658348
SGTC_2958 9077254 16.72 µM -0.12689202151733 0.444105622026737 no 1867 0.449512930750973 2783 16457351
SGTC_176 1486-1328 72.834 µM -0.128177810649817 0.443614240357344 no 1868 0.449004129871094 2698 22310231
SGTC_1902 st060212 70.5 µM -0.12915082906244 0.443242445817921 no 1869 0.448619151489902 2624 688944
SGTC_742 0kpi-0133 140 µM -0.12980831745729 0.442991244928869 no 1870 0.448359041109062 2762 2728852
SGTC_3034 9090421 49.47 µM -0.130885468627812 0.442579756685398 no 1871 0.447932955071102 2610 17173761
SGTC_717 1532-0246 73.2 µM -0.131249739900177 0.442440613472872 no 1872 0.447788874747516 2707 9561992
SGTC_1652 st011932 78 µM -0.131557008569253 0.442323249457995 no 1873 0.447667346035471 2653 1551076
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.133113676597024 0.441728744183911 no 1874 0.447051739522051 2643 165521
SGTC_1776 st049249 45.9 µM -0.134687428636796 0.441127847788855 no 1875 0.446429506554862 2676 1822314
SGTC_2302 7771753 200 µM -0.13510788790714 0.440967329203161 no 1876 0.446263286858547 2706 2203047
SGTC_316 k060-0003 58.6 µM -0.135643243483552 0.440762960734306 no 1877 0.446051659002085 2788 6152314
SGTC_1435 4092-0789 56.7 µM -0.135821635821621 0.440694864134665 no 1878 0.445981143322603 2672 2248285
SGTC_1895 st058434 18.3 µM -0.136889712747255 0.440287190512426 no 1879 0.445558985162893 2686 5393175
SGTC_1237 0330-0133 46.1 µM -0.137831837353661 0.439927644074534 no 1880 0.445186660961578 2671 X1237 YHR072W ERG7
SGTC_886 0866-0150 153 µM -0.141799781291628 0.438413890290516 no 1881 0.443619078413932 2834 271463
SGTC_2349 9023730 187.07 µM -0.142671395814931 0.438081492912874 no 1882 0.443274854203286 2764 4126287
SGTC_1555 citronellol 128 µM -0.143608879708132 0.437724024471611 no 1883 0.44290466417694 2667 8842 A terpine precursor.
SGTC_1286 0929-0070 131 µM -0.143729080459265 0.437678194846932 no 1884 0.442857203365443 2773 1420408
SGTC_2531 methyl deoxycholate 70.07 µM -0.144582590627734 0.437352796246111 no 1885 0.442520221727982 2672 16667744 Haematoxylin.
SGTC_1283 0922-0125 16.4 µM -0.145367456330368 0.43705360556481 no 1886 0.442210378892485 2769 3360884
SGTC_2586 curcumin 80 µM -0.145767707778944 0.4369010436246 no 1887 0.442052384511211 2767 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1861 st057647 17.4 µM -0.146537501672692 0.436607651346681 no 1888 0.441748543687137 2863 688668
SGTC_2880 9042983 58.44 µM -0.146864951444591 0.436482860665508 no 1889 0.44161930829167 2805 6464714
SGTC_1950 st077106 7.18 µM -0.147657277527059 0.436180932405702 no 1890 0.441306624774844 2756 13831864
SGTC_947 3447-0010 211 µM -0.148096543186032 0.436013559359123 no 1891 0.441133288751098 2634 748350
SGTC_2170 morpholine 200 µM -0.148777644581598 0.435754062501009 no 1892 0.440864545665876 2775 121171 Reacts with secondary amines.
SGTC_1664 st014217 9.02 µM -0.149526631135705 0.435468733608056 no 1893 0.440569048485363 2683 3982782
SGTC_2020 4017018 200 µM -0.152701601509925 0.43425959294791 no 1894 0.439316798878089 2776 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2175 5807670 165.306 µM -0.152819398610332 0.434214743416991 no 1895 0.439270349771213 2713 241186
SGTC_3256 9138902 49.47 µM -0.153171433869537 0.434080716166193 no 1896 0.439131542143422 2651 17228773
SGTC_2876 9059903 25.97 µM -0.153585689707988 0.433923009934057 no 1897 0.438968210506132 2670 6916095
SGTC_1491 4138-0063 26.5 µM -0.154576365597281 0.433545904629608 no 1898 0.438577651769464 2660 23883227
SGTC_3230 9131665 49.47 µM -0.154793166633005 0.43346338637988 no 1899 0.438492189257492 2668 15943720
SGTC_1168 k815-0004 80.5 µM -0.155035077165586 0.433371314442209 no 1900 0.438396832020389 2670 642433
SGTC_720 r052-1644 49.9 µM -0.155299689587157 0.433270606232641 no 1901 0.438292530159786 2794 1422863 YOR257W CDC31
SGTC_2104 5389443 200 µM -0.157102196995823 0.432584709858531 no 1902 0.437582153066215 2836 2244536
SGTC_2245 6637752 200 µM -0.15744095017923 0.432455828929801 no 1903 0.437448671143558 2858 681890
SGTC_1184 1269-1718 139 µM -0.158234281773552 0.432154028729637 no 1904 0.437136095540194 2824 5403821
SGTC_1103 duloxetine 36.1 µM -0.158588843688699 0.432019158630331 no 1905 0.436996409499802 2854 60835 A selective serotonin reuptake inhibitor.
SGTC_1499 4480-0877 67.3 µM -0.158956975493173 0.431879135129417 no 1906 0.436851385668712 2692 2861909
SGTC_2838 9002687 71.43 µM -0.159942561719815 0.431504297348135 no 1907 0.436463160333818 2665 6457060
SGTC_3075 9116269 49.47 µM -0.160378499592347 0.431338521272906 no 1908 0.436291462611851 2852 17015205 YNL244C SUI1
SGTC_1604 st002052 72.4 µM -0.160907285393047 0.431137453728743 no 1909 0.436083212082647 2807 6254834 YHR062C RPP1
SGTC_1852 st056254 31.4 µM -0.1628130982866 0.430412928539767 no 1910 0.435332797469817 2727 442583
SGTC_841 0251-0215 91.2 µM -0.163354671524748 0.430207083456275 no 1911 0.435119595147278 2743 3888614
SGTC_2705 st078069 42.8 µM -0.164791897475233 0.429660904293896 no 1912 0.434553890864512 2771 1530061
SGTC_2173 5763948 167 µM -0.165115590003262 0.429537912167127 no 1913 0.434426501192631 2686 2867177
SGTC_2343 7990716 14.84 µM -0.16653392001962 0.428999075898614 no 1914 0.43386839576983 2725 6456862
SGTC_275 trichlorophene 5.69 µM -0.166652230150484 0.428954134784927 no 1915 0.433821847294758 2795 62616
SGTC_1716 st033144 30.6155 µM -0.16671978922541 0.428928472306396 no 1916 0.4337952669572 2786 674617
SGTC_2488 5268135 45.7 µM -0.167287671446557 0.428712772753626 no 1917 0.433571852104134 2835 1270356 YLR208W SEC13
SGTC_2673 kobusone 100 µM -0.168357957424383 0.428306302357616 no 1918 0.433150840526918 2714 6710676 An epoxy ketone and protein crosslinker.
SGTC_2540 epiandrosterone 100 µM -0.168432493741405 0.428277997978588 no 1919 0.433121523470586 2731 441302 A steroid.
SGTC_3336 9143619 71.43 µM -0.168668084203795 0.428188537415983 no 1920 0.433028862084999 2689 45595730
SGTC_3129 9127257 49.47 µM -0.169456204917085 0.427889291868375 no 1921 0.432718908765192 2737 837894
SGTC_2028 5153890 36.43 µM -0.169478261876352 0.427880917545494 no 1922 0.432710234765063 2702 2830968 YPR165W RHO1
SGTC_343 4130-2827 29.8 µM -0.169780030280333 0.4277663489858 no 1923 0.432591566217958 2753 1118244
SGTC_3169 9102970 49.47 µM -0.170398492098355 0.427531564519123 no 1924 0.432348378966271 2692 17027839
SGTC_1295 1013-0063 9.78 µM -0.170713845419974 0.427411857929081 no 1925 0.432224387787318 2757 6826038
SGTC_787 4152-0075 138 µM -0.171544229516881 0.427096680150616 no 1926 0.431897927853735 2739 9566539
SGTC_3177 9107506 49.47 µM -0.17264531165816 0.426678828928384 no 1927 0.431465116546594 2795 8897194
SGTC_3327 9140648 26.9345 µM -0.172900755874088 0.426581901781426 no 1928 0.431364718750435 2818 8029710
SGTC_2356 9061756 188.97 µM -0.173041627759641 0.426528450480979 no 1929 0.431309353463174 2777 20104043
SGTC_2029 5175081 200 µM -0.173285690886705 0.426435848316606 no 1930 0.431213435282134 2707 1380876
SGTC_506 n9-isopropylolomoucine 153 µM -0.173728631450313 0.426267798654907 no 1931 0.431039367515903 2789 6610355
SGTC_2222 6885208 172.143 µM -0.174112240636626 0.42612226986753 no 1932 0.430888626748068 2744 609514
SGTC_1438 4092-1045 4 µM -0.174725057507295 0.4258898080563 no 1933 0.430647838798812 2709 1351342
SGTC_2398 5228213 48.84 µM -0.175167885367142 0.425721844751263 no 1934 0.430473858956931 2827 80771 YMR134W ERG29
SGTC_1548 st061468 90.8 µM -0.176529180531041 0.425205594019642 no 1935 0.429939112944713 2818 390799
SGTC_1181 1222-0449 220 µM -0.178186166421247 0.424577380129203 no 1936 0.429288386734349 2890 658318
SGTC_1731 st035964 63 µM -0.179363739752008 0.424131042493985 no 1937 0.428826050563252 2778 6739575
SGTC_2242 6630449 61.2675 µM -0.182553600735978 0.422922474343177 no 1938 0.427574146837074 2921 691249 YDR170C SEC7
SGTC_1959 st077091 55.8 µM -0.184192801325954 0.422301698603312 no 1939 0.426931103287923 2699 821356 YKL052C ASK1
SGTC_291 SEC14.278 35.5 µM -0.184313185229853 0.422256116036715 no 1940 0.426883885403938 2828 1068044
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.184423862329839 0.422214209805727 no 1941 0.426840475720243 2865 5024745
SGTC_3248 9135562 49.47 µM -0.184837154706422 0.422057730607157 no 1942 0.426678382350816 2775 17650701
SGTC_2045 5106652 78.05 µM -0.18485759985638 0.422049990060874 no 1943 0.426670364079285 2869 673349
SGTC_763 3453-1109 128 µM -0.185102861360163 0.421957136253505 no 1944 0.42657417867484 2750 1560353
SGTC_2432 5630864 12.22 µM -0.185803303169478 0.421691979164967 no 1945 0.426299507043511 2879 5714970
SGTC_702 1488-0190 94 µM -0.186250557211273 0.421522686619538 no 1946 0.426124139291559 2839 949357
SGTC_672 1441-0018 53.7 µM -0.18810444255023 0.420821117462618 no 1947 0.425397389306145 2726 251141
SGTC_2366 9070441 60.58 µM -0.189001929559111 0.420481570012654 no 1948 0.42504565223908 2763 6837235
SGTC_765 1319-0117 244 µM -0.191158219760357 0.419666020165313 no 1949 0.424200817876664 2742 3487746 YGL099W LSG1
SGTC_389 tpck 16.7 µM -0.192550353986748 0.419139671601645 no 1950 0.423655564488748 2814 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_504 lovastatin 124 µM -0.192568236439323 0.419132911408854 no 1951 0.423648561466157 2758 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.19260289819025 0.419119808122154 no 1952 0.423634987500522 2930 688798
SGTC_548 1436-0017 110 µM -0.194456392628594 0.418419257022638 no 1953 0.422909268789655 2855 9677137
SGTC_1570 verbenone 133 µM -0.19501149208182 0.4182095005711 no 1954 0.422691975481148 2911 29025 A natural terpanoid with antifungal properties.
SGTC_1793 st048256 72.231 µM -0.195658276516096 0.41796512829047 no 1955 0.422438821821897 2718 672022
SGTC_3287 9117173 37.0625 µM -0.19592856290952 0.417863016313268 no 1956 0.422333040279629 2784 2789709
SGTC_803 4488-1585 147 µM -0.196520586001092 0.417639374212971 no 1957 0.422101360756448 2874 747204
SGTC_678 1218-2179 85.9 µM -0.197076727747647 0.417429310878514 no 1958 0.421883747420346 2743 6820081 YOR116C RPO31
SGTC_2254 7938975 95.19 µM -0.197372623612138 0.417317556036347 no 1959 0.421767975707401 2962 2969277
SGTC_2914 7968218 45.32 µM -0.197444855970336 0.41729027611542 no 1960 0.421739715224036 2858 2977111
SGTC_700 3453-2283 142 µM -0.198523175255572 0.416883075779149 no 1961 0.42131787717277 2942 565664
SGTC_1688 st021091 57.6 µM -0.198774320402566 0.41678824987372 no 1962 0.421219642243372 2764 3656366
SGTC_2331 7980721 200 µM -0.198784037521693 0.41678458103836 no 1963 0.421215841509873 2832 2981221
SGTC_247 mechlorethamine 29.705 µM -0.199939827781847 0.416348247914686 no 1964 0.420763820608757 2750 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3185 9108267 49.47 µM -0.201455739497076 0.415776118308478 no 1965 0.420171117328095 2838 4910486
SGTC_792 4534-1957 155 µM -0.201776453563723 0.415655098464359 no 1966 0.420045745129032 2813 1717904
SGTC_2048 5246248 200 µM -0.202842359017521 0.415252941923295 no 1967 0.419629124193138 2825 677046
SGTC_2065 5221596 34.26 µM -0.203275054877875 0.415089714974973 no 1968 0.419460025907067 2891 788581
SGTC_1457 k015-0032 57.3 µM -0.20571275777354 0.414170408818914 no 1969 0.418507646217038 2753 4302660
SGTC_3031 9088762 49.47 µM -0.20612589139113 0.414014654375193 no 1970 0.418346287305871 2729 205253
SGTC_895 0964-0006 13.7 µM -0.207366392110716 0.413547057750134 no 1971 0.417861863669779 2796 6738897
SGTC_2295 7971645 200 µM -0.209637866527078 0.412691162169128 no 1972 0.416975161534549 2845 2978226 YKL099C UTP11
SGTC_3092 9117248 49.47 µM -0.211302615838334 0.412064144931253 no 1973 0.416325570931825 2780 17141857
SGTC_3183 9108214 49.47 µM -0.211923902076869 0.411830198841236 no 1974 0.416083201467718 2825 4974831
SGTC_758 0868-0029 16 µM -0.213105627600644 0.411385305207148 no 1975 0.415622287637522 2907 762687
SGTC_85 0868-0259 160.055 µM -0.214087840952853 0.411015610181761 no 1976 0.415239278750094 2846 83173
SGTC_547 1120-0019 610 nM -0.214092605580537 0.411013817017127 no 1977 0.415237421004784 2758 3676939
SGTC_1923 st058458 19.1 µM -0.216257400524102 0.410199290710717 no 1978 0.414393556399655 3036 3534982
SGTC_216 k038-0035 28.382 µM -0.216698649219916 0.410033313760758 no 1979 0.414221600380071 2818 4444231 YPR107C YTH1
SGTC_1413 3910-0535 34.4 µM -0.217015460461907 0.409914154250821 no 1980 0.414098148170137 2910 2876951
SGTC_1838 st055369 84.5 µM -0.21722581130601 0.409835041376986 no 1981 0.414016185196633 2769 676036
SGTC_1815 st051655 58.2 µM -0.221261256249355 0.40831802633874 no 1982 0.412444507690905 2880 5984156
SGTC_301 4119-0100 24.5 µM -0.222422344838429 0.407881800225582 no 1983 0.411992559385801 2822 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_496 calpeptin 138 µM -0.223762652287762 0.407378382787683 no 1984 0.411470996125996 2861 73364 A calpain inhibitor.
SGTC_552 k242-0005 476 µM -0.223775119675071 0.407373700772636 no 1985 0.411466145336719 2910 4088318
SGTC_392 N-ethylmaleimide 8.33 µM -0.223818076267478 0.40735756891249 no 1986 0.411449431964428 2842 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2952 9073731 13.78 µM -0.224098868087106 0.407252124606859 no 1987 0.411340186610686 2828 16457353
SGTC_2680 butyl paraben 22.24 µM -0.225193045841646 0.406841297860728 no 1988 0.410914549569322 2781 7184 An antifungal and steroid mimetic.
SGTC_25 0118-0223 35.662 µM -0.225601160735758 0.406688090738344 no 1989 0.410755818993843 2943 5333628
SGTC_1518 st038567 90.8 µM -0.227059772660638 0.406140641881865 no 1990 0.410188631929556 2776 77966
SGTC_1446 4239-0190 62 µM -0.2273574579889 0.40602893659467 no 1991 0.410072898842167 2823 1340085
SGTC_1033 k072-0102 21.3 µM -0.228815841602397 0.405481794393254 no 1992 0.409506026795938 2991 5965931
SGTC_2999 9069765 71.4286 µM -0.230407027196874 0.404885039481707 no 1993 0.40888775056346 2896 2097066
SGTC_218 alverine citrate 93.75 µM -0.232509181043764 0.404096991352055 no 1994 0.408071278574957 2940 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_687 k029-0044 34.9 µM -0.234633559323912 0.403301007004945 no 1995 0.407246579995756 2960 5829338
SGTC_3064 1327-0027 10 µM -0.235468913084186 0.402988117404199 no 1996 0.40692240217406 2817 16000455 YPR107C YTH1
SGTC_3353 9151644 39.2805 µM -0.235996272901162 0.402790621797927 no 1997 0.406717781149336 2944 4909158
SGTC_2739 tacrine 100.86 µM -0.237361019049803 0.402279641292921 no 1998 0.406188363979744 2926 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_834 0312-0008 75.7 µM -0.237492097485561 0.402230572422493 no 1999 0.406137524578393 2817 6385573 YIL048W NEO1
SGTC_3231 9132313 49.47 µM -0.237739087599753 0.402138116504921 no 2000 0.406041732576705 2883 4905967
SGTC_1686 st019653 115.5 µM -0.237955517295504 0.402057104782924 no 2001 0.40595779767161 2957 97252
SGTC_3152 9099253 49.47 µM -0.239080813324523 0.401635963512752 no 2002 0.405521459582596 2921 25236131
SGTC_229 benomyl 22.8748 µM -0.239416808147131 0.401510239800283 no 2003 0.405391198962106 2905 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_858 0438-0351 2.77 µM -0.24063025321341 0.401056273682954 no 2004 0.404920850176438 2862 2799119
SGTC_96 0929-0093 37.281 µM -0.244212971735161 0.399716712002366 no 2005 0.403532940590483 2833 6991579
SGTC_3109 9122853 49.47 µM -0.24444945604935 0.399628332949608 no 2006 0.403441371435909 2879 1234709
SGTC_2629 bisabolol 100 µM -0.244475568553989 0.399618574484667 no 2007 0.403431260730426 2986 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_171 k064-0041 9.68 µM -0.244966193209188 0.399435235544302 no 2008 0.403241303928438 2853 53325
SGTC_2689 tacrolimus 100 µM -0.246105479263611 0.399009587343674 no 2009 0.402800290833084 2923 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2009 4012297 12.05 µM -0.247232812122235 0.39858852314216 no 2010 0.40236402646734 2948 45595307
SGTC_2699 st077704 54.6 µM -0.248449304116275 0.39813428997873 no 2011 0.401893394974373 2898 645852
SGTC_651 3253-0966 34.4 µM -0.249253212060369 0.397834189721967 no 2012 0.401582460333404 2871 781462
SGTC_556 4058-0063 51.5 µM -0.249594284500383 0.397706885028393 no 2013 0.401450559517177 2887 6615692
SGTC_1972 st070201 17.4 µM -0.250661426026977 0.397308646727382 no 2014 0.401037943123459 2985 2829099
SGTC_2733 amorolfine 100 µM -0.25155118910862 0.396976684719432 no 2015 0.400693995470581 2883 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_906 1165-0455 526 µM -0.251680039897761 0.396928617916111 no 2016 0.400644193163047 2849 3252859
SGTC_1381 2324-0066 62.1 µM -0.252122950741392 0.396763405352872 no 2017 0.40047301536494 2970 10885928
SGTC_2258 7960471 200 µM -0.252427905464783 0.396649663315665 no 2018 0.400355166460272 2918 2974708
SGTC_621 3584-0052 32.1 µM -0.252810362385628 0.396507026933272 no 2019 0.400207379870911 2936 2273927
SGTC_1956 st077085 54 µM -0.253021939182293 0.396428125828033 no 2020 0.400125629837967 2896 24208685
SGTC_3315 9136395 68.55 µM -0.253352622818679 0.39630481596031 no 2021 0.399997867513224 2972 16876844
SGTC_12 0849-0099 9.267 µM -0.254159621541118 0.396003934732254 no 2022 0.399686121922196 2891 6071388
SGTC_2945 9067681 61.76 µM -0.254191544537581 0.395992033841748 no 2023 0.399673791303481 2790 16456930
SGTC_1123 mangostin 811.285 nM -0.254468887357364 0.395888644541753 no 2024 0.399566668712157 2929 5281650 An antioxidant.
SGTC_2685 mycophenolic acid 18.85 µM -0.255703740028908 0.395428398734338 no 2025 0.399089803516946 2901 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1370 2001-0092 44.6 µM -0.255947196149134 0.395337676628652 no 2026 0.398995805390438 3070 790957
SGTC_406 estrone 100 µM -0.256707668946986 0.395054328669984 no 2027 0.39870222546803 3045 5870 A steroid.
SGTC_948 3448-0295 75.3 µM -0.257077135185172 0.394916687611345 no 2028 0.398559613993262 2843 678569
SGTC_3233 9132340 49.47 µM -0.257584713877002 0.394727615485242 no 2029 0.398363714133106 2883 17682950
SGTC_1388 3346-4487 254 µM -0.259099739180643 0.394163418958272 no 2030 0.397779143016463 2949 3345614
SGTC_471 1-acyl-paf 4 µM -0.259836037979562 0.393889300842376 no 2031 0.397495125570347 2863 16759367
SGTC_912 3474-0017 2.18 µM -0.260000513988431 0.393828074926054 no 2032 0.397431688561463 3043 3360550
SGTC_3035 9091303 49.47 µM -0.260556397188302 0.393621167775993 no 2033 0.397217309188241 2867 25237002
SGTC_2767 sibutramine 71.45 µM -0.261216315130747 0.393375576499071 no 2034 0.396962848564962 3056 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_362 0310-0100 9.03 µM -0.262716977524328 0.392817256640135 no 2035 0.396384365077309 2994 790235
SGTC_330 1488-0319 80.1 µM -0.264219878718418 0.392258324772289 no 2036 0.395805247097632 2929 6846614
SGTC_2053 5265679 138 µM -0.264359839077701 0.392206284536033 no 2037 0.395751327385067 2853 764595
SGTC_1989 st071868 50.2 µM -0.265258140538176 0.3918723228939 no 2038 0.395405304384303 3017 16414057
SGTC_1530 rhein 70.4 µM -0.26557019058756 0.391756330637663 no 2039 0.395285122930824 2858 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3163 9099914 49.47 µM -0.267780431534574 0.390935037020086 no 2040 0.394434167094237 2967 16268368
SGTC_853 0419-0306 21 µM -0.268708034887079 0.390590497639904 no 2041 0.394077184091686 2856 762713
SGTC_1266 0828-0227 32.9 µM -0.269071494084718 0.390455521525269 no 2042 0.39393733308037 2997 3913820
SGTC_740 k014-0057 261 µM -0.26924017006816 0.390392885610923 no 2043 0.393872434960632 2981 4012779
SGTC_1712 st032288 53.4 µM -0.270195581984072 0.390038157961799 no 2044 0.393504895702332 2966 2883011
SGTC_221 trifluoperazine 10.304 µM -0.273085887300693 0.388965596936776 no 2045 0.39239359743455 2916 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3223 9129970 49.47 µM -0.273676151206286 0.388746660109036 no 2046 0.392166753425371 2865 17248386
SGTC_1249 0481-0015 10.2 µM -0.274529561648993 0.388430181173533 no 2047 0.39183884451483 2859 4227577
SGTC_1802 st050112 57.9 µM -0.275127510822997 0.388208481664791 no 2048 0.391609138143278 2875 4662563
SGTC_3167 9103034 49.47 µM -0.276757885515046 0.387604178626635 no 2049 0.390983010459534 2873 5127859
SGTC_1322 1348-1070 12 µM -0.277235992140871 0.387427018585469 no 2050 0.390799452296849 2956 6758089
SGTC_2120 5538279 151.968 µM -0.279013043275551 0.386768746835463 no 2051 0.390117407510168 2939 2058197
SGTC_1304 1165-0502 251 µM -0.279050694932948 0.386754803075723 no 2052 0.39010296018845 2917 767425
SGTC_2477 5967686 25.23 µM -0.279373970742245 0.386635088461455 no 2053 0.389978922239712 2868 776118
SGTC_829 1635-0120 117 µM -0.27998030692584 0.386410580801836 no 2054 0.38974630685219 3036 285054
SGTC_351 caspofungin 25 nM -0.280232330981245 0.386317275218832 no 2055 0.389649631717539 2923 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2364 9055074 200 µM -0.28082522772642 0.38609779600677 no 2056 0.389422226502062 2988 6470630
SGTC_2231 micatex 6.853 µM -0.282578984626173 0.38544880182312 no 2057 0.388749795924206 2932 20737 An antifungal of unknown mechanism.
SGTC_900 1112-0045 141 µM -0.283159572540254 0.385234020374319 no 2058 0.38852725852482 2932 56211 YIL048W NEO1
SGTC_489 paxilline 115 µM -0.285038875818458 0.384539036628242 no 2059 0.387807179086185 2976 105008 A toxic potassium channel blocker.
SGTC_2605 digitonin 300 nM -0.28519427480179 0.384481585219809 no 2060 0.387747653179113 3034 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_624 k048-0052 28 µM -0.286689317572405 0.38392899381596 no 2061 0.387175108874504 2958 6835531
SGTC_812 4251-0442 148 µM -0.287169925617594 0.383751403551425 no 2062 0.386991106397934 3042 5723007
SGTC_77 0828-0286 12.516 µM -0.288341100999343 0.383318742921668 no 2063 0.386542824209078 2886 745345
SGTC_1065 prochlorperazine maleate 2.48 µM -0.290870989364621 0.38238463791742 no 2064 0.385574994793539 2940 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2262 9014885 67.46 µM -0.292135377495522 0.381918046724484 no 2065 0.385091559273086 2912 6457424
SGTC_203 k066-0004 30.888 µM -0.292227768138512 0.381883958955563 no 2066 0.385056240941486 2977 6795412
SGTC_2050 5263056 171 µM -0.292451741644505 0.3818013271472 no 2067 0.384970626158491 3083 763468 YGL055W OLE1
SGTC_425 3825-7017 13.1 µM -0.295369037480276 0.380725525930324 no 2068 0.38385599161463 3165 3397440
SGTC_366 0181-0206 4.31 µM -0.295636313934461 0.380627009264631 no 2069 0.383753919039611 3128 274874
SGTC_2270 7924575 90.91 µM -0.296551920815607 0.380289580197488 no 2070 0.383404310987715 3093 1262135
SGTC_1984 st072354 53.1 µM -0.296778363625593 0.380206143152321 no 2071 0.383317862494706 2898 5762938
SGTC_1354 1498-1681 81 µM -0.297559599475222 0.379918325154268 no 2072 0.383019656701252 3019 5754243
SGTC_1218 1348-1416 30.7 µM -0.298353647883082 0.379625854977452 no 2073 0.382716631251511 2911 6787668
SGTC_2697 mebhydrolin 72.4 µM -0.298615793584639 0.379529314513669 no 2074 0.382616606730911 3092 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3227 9130768 49.47 µM -0.299228792539709 0.37930359455666 no 2075 0.382382740938244 2927 17720899
SGTC_3081 9117243 49.47 µM -0.299288033490713 0.379281782889211 no 2076 0.382360142140438 3108 45595589
SGTC_395 anisomycin 6.25 µM -0.299396763564258 0.379241751037431 no 2077 0.382318665642504 2983 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_842 0271-0008 11.1 µM -0.299457855819896 0.379219258876163 no 2078 0.382295361800987 3050 1221709
SGTC_2341 7987486 176.74 µM -0.301119849849289 0.378607524377323 no 2079 0.381661552547287 3096 1258686
SGTC_2983 9022671 12.99 µM -0.301266651244192 0.378553505395173 no 2080 0.38160558436269 3130 6405161
SGTC_3161 9100388 49.47 µM -0.301850215512275 0.378338792846785 no 2081 0.38138312436549 2954 25236368
SGTC_1811 st050069 61.5 µM -0.301896859114397 0.378321632746814 no 2082 0.381365345091044 2955 3877702
SGTC_2933 9026794 32.47 µM -0.302414165413991 0.378131332757608 no 2083 0.381168178771412 2975 17586027
SGTC_2836 9010338 19.48 µM -0.302737274598227 0.378012486501748 no 2084 0.381045044459366 2940 2994051
SGTC_3239 9133757 49.47 µM -0.303052051490881 0.377896716135985 no 2085 0.380925097098728 2930 17036923
SGTC_1347 1493-0251 600 nM -0.303598447938179 0.377695785506897 no 2086 0.380716917084557 3080 3986378
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.304587420942883 0.377332186930735 no 2087 0.380340200850536 2938 688803
SGTC_2066 5222451 176 µM -0.304600463127051 0.377327392662342 no 2088 0.380335233623361 2934 2281147
SGTC_745 0469-0705 296 µM -0.306043531187404 0.376797042034764 no 2089 0.37978575089012 3147 3486736
SGTC_1792 st045773 43.6 µM -0.309765075159057 0.375430389722172 no 2090 0.378369806045759 2930 2919270
SGTC_1440 4100-1550 40 µM -0.311096489483861 0.374941836546278 no 2091 0.377863634911018 2985 742806
SGTC_991 3996-0057 64.7 µM -0.312860929963191 0.374294696633096 no 2092 0.377193160926213 3040 715343
SGTC_3307 9126885 69.2785 µM -0.313024547345557 0.374234704957911 no 2093 0.377131006281154 2952 24824909
SGTC_2583 asiatic acid 100 µM -0.313523793696501 0.374051670955523 no 2094 0.376941373254159 3139 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1366 1683-0113 21.9 µM -0.314079856819443 0.373847840176293 no 2095 0.376730193965768 2957 708623
SGTC_1614 st002383 48.6 µM -0.314194667751411 0.373805759414659 no 2096 0.376686596149563 3024 1947235
SGTC_3171 9103192 49.47 µM -0.314807515095797 0.373581162679548 no 2097 0.376453902714242 3052 13018434
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.316448484264475 0.372979990682183 no 2098 0.375831060542088 2972 688669
SGTC_265 mycophenolic acid 32.932 µM -0.316812532535465 0.372846662797058 no 2099 0.375692927057971 3217 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1822 st052468 42 µM -0.317961356468703 0.372426021093993 no 2100 0.375257124970532 3020 2873678
SGTC_1226 3909-7979 35.4 µM -0.318750593760541 0.372137130112309 no 2101 0.374957822938006 3078 6615510
SGTC_1696 st025591 34.7925 µM -0.318776799664254 0.372127538984382 no 2102 0.37494788617775 2971 2787147
SGTC_1128 3448-9350 235 µM -0.31907607426683 0.372018012766385 no 2103 0.374834413057541 3035 619386
SGTC_2163 5671233 125 µM -0.319484911841689 0.371868406270571 no 2104 0.374679415494636 3187 701023
SGTC_503 tyrphostin 8 294 µM -0.322164771325451 0.370888241550143 no 2105 0.373663935633275 3093 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_815 1582-0027 36.9 µM -0.322456384159795 0.370781633883554 no 2106 0.373553487456548 3060 3128206
SGTC_2051 5263410 176 µM -0.322527069617029 0.370755794224561 no 2107 0.373526716947725 3057 227584
SGTC_3247 9135149 49.47 µM -0.323260357005176 0.370487769307412 no 2108 0.373249037059821 2978 8934436 YOR116C RPO31
SGTC_1697 st025554 27.742 µM -0.323333755285692 0.370460944855862 no 2109 0.373221246358428 2950 1269519
SGTC_2545 solidagenone 89.61 µM -0.324537313048572 0.370021177382492 no 2110 0.372765638923946 2887 6708572 An anti ulcer agent
SGTC_1498 4478-3555 97.6 µM -0.325736784463398 0.369583072035129 no 2111 0.372311755398141 3005 3437919
SGTC_215 1287-0124 461.5 µM -0.325978001713065 0.369494988178333 no 2112 0.37222049947307 3024 5560863
SGTC_328 k915-0120 63.5 µM -0.328379130976159 0.36861855632417 no 2113 0.371312510007163 3093 6624543
SGTC_2740 felodipine 17.08 µM -0.33176046363742 0.36738550109747 no 2114 0.370035070209301 3073 3333 L-type calcium channel blocker
SGTC_1361 1608-0041 5.61 µM -0.332855034021625 0.366986641167287 no 2115 0.369621856702709 3000 X1361
SGTC_1086 cerivastatin 2.18 µM -0.333883805610072 0.366611889064527 no 2116 0.369233620245631 3042 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1829 berberine 14.4 µM -0.334093920692078 0.366535365763922 no 2117 0.369154343679573 3159 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1927 st060202 13.8 µM -0.334625957825074 0.366341623121679 no 2118 0.368953630593146 3042 688887
SGTC_2822 7994718 71.43 µM -0.335568203092114 0.365998585776197 no 2119 0.368598252591489 2973 1018011
SGTC_979 1426-2828 121 µM -0.336408108755968 0.365692896833112 no 2120 0.368281567777742 3133 747872
SGTC_1690 st023502 41.2 µM -0.336561413770674 0.365637109706503 no 2121 0.368223774066616 3084 24207482
SGTC_1826 st055655 41.6 µM -0.33723281328969 0.365392823399738 no 2122 0.367970701572486 3067 676168
SGTC_1084 voriconazole 435 nM -0.339326842746726 0.364631269386452 no 2123 0.367181761674787 3117 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2769 toremifene 3.73 µM -0.339449714910463 0.364586599945952 no 2124 0.367135486124038 3216 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_144 4161-2749 112.381 µM -0.340323940190898 0.364268833681709 no 2125 0.366806295162946 3029 797501 YMR168C CEP3
SGTC_2569 tetrandrine 100 µM -0.340330297987943 0.364266523070231 no 2126 0.36680390148246 3050 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1138 3761-0006 1.03 µM -0.340948428215587 0.364041899831382 no 2127 0.366571203122019 3052 12061087
SGTC_3103 9120822 49.47 µM -0.341410569370471 0.363873992194263 no 2128 0.366397259696056 3223 17141819
SGTC_2290 7904846 200 µM -0.341734064809946 0.363756473620254 no 2129 0.366275516892063 3070 2962154
SGTC_208 k072-0098 12.366 µM -0.341791724342023 0.363735528562217 no 2130 0.366253818978525 3007 5948901
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.342053007812458 0.363640621389969 no 2131 0.366155500506565 2974 2333 A French combination drug.
SGTC_2317 5986382 200 µM -0.3431825125985 0.363230442608731 no 2132 0.365730579821436 3074 877883
SGTC_1190 1486-1332 13 µM -0.346474472106956 0.362035866035876 no 2133 0.364493082925489 3067 4150046
SGTC_1487 3970-0795 2.82 µM -0.347025310174931 0.361836110359604 no 2134 0.36428615209388 3115 3765103
SGTC_1871 st057448 67.3 µM -0.347768940726475 0.361566500211052 no 2135 0.364006858536365 3224 691747
SGTC_2420 aureobasidin a 50 nM -0.347913607015796 0.361514058087383 no 2136 0.363952533003921 3279 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2134 5324836 1.464 µM -0.347967232583688 0.361494619259755 no 2137 0.363932396059355 3013 699272
SGTC_1175 0741-0056 27.6 µM -0.348630943384751 0.361254059157943 no 2138 0.363683197043582 3209 765927
SGTC_2489 cantharidin 73.42 µM -0.350720753788185 0.360496971948753 no 2139 0.362898927056524 2988 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1836 st055642 81 µM -0.351120310011892 0.360352284648003 no 2140 0.362749045802373 3037 8571
SGTC_1658 st012944 20 µM -0.353157530059984 0.359614877812433 no 2141 0.361985172575661 3097 24207260
SGTC_1893 st059353 36.1 µM -0.353933088966813 0.359334288065649 no 2142 0.361694514307331 3091 3112488
SGTC_1164 k060-0068 93.7 µM -0.353982875759072 0.359316278272463 no 2143 0.361675858302423 3029 5963676
SGTC_929 2805-0021 398 µM -0.355925567702429 0.358613776458737 no 2144 0.360948153867704 3111 3098024
SGTC_1007 4101-0031 70 µM -0.356203324912694 0.35851337497301 no 2145 0.360844151058874 3177 1146276
SGTC_1493 4348-0038 111 µM -0.357055703692566 0.358205324891346 no 2146 0.360525052460613 3113 800424
SGTC_1965 Pectolinarigenin 58.4 µM -0.357272926815853 0.358126835101741 no 2147 0.360443747800552 3043 5320438 An anti-inflammatory.
SGTC_2243 6634756 200 µM -0.357905571925026 0.357898273988177 no 2148 0.360206990390053 3261 885676
SGTC_2871 9038510 12.99 µM -0.357914715364433 0.357894971032747 no 2149 0.360203568995442 3237 4945164
SGTC_106 0092-0003 11.579 µM -0.358170005883614 0.357802754757456 no 2150 0.360108046049909 3083 1072148
SGTC_2298 7976326 193.81 µM -0.358802120202841 0.357574457566046 no 2151 0.359871563224318 3005 2235818
SGTC_223 busulfan 5 mM -0.359181770399577 0.357437365914348 no 2152 0.359729556537462 3118 2478 A DNA alkylator.
SGTC_462 ag-879 158 µM -0.361059183015587 0.356759703099948 no 2153 0.35902760259003 3142 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1485 3909-9022 254 µM -0.361444861585232 0.356620546089331 no 2154 0.358883458380859 3118 714516
SGTC_1875 nocodazole 6 µM -0.362870751280693 0.356106235443164 no 2155 0.3583507183808 3180 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3077 9117319 49.47 µM -0.363450741966953 0.355897110780231 no 2156 0.358134101420063 3048 17154678
SGTC_100 0086-0128 49.5915 µM -0.364126541329893 0.35565349549724 no 2157 0.357881759096128 3082 93297
SGTC_3166 9102297 49.47 µM -0.364387234100025 0.355559535510928 no 2158 0.357784433451956 3093 25237072
SGTC_1465 k213-0056 144 µM -0.366350818743794 0.354852094447576 no 2159 0.357051656730297 3034 24048857 YMR208W ERG12
SGTC_1605 st000082 49.1 µM -0.369253528481433 0.353807221807894 no 2160 0.355969380291226 3169 1114022
SGTC_2741 miltefosine 3.04 µM -0.369447600176831 0.353737402028873 no 2161 0.35589706184722 3055 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1282 0886-0010 32.4 µM -0.369661217883918 0.353660556009348 no 2162 0.355817465815683 3237 2836211 YNL267W PIK1
SGTC_1043 0916-0009 19.3 µM -0.371613854393268 0.352958398723286 no 2163 0.355090186190398 3234 3101130
SGTC_2293 7624732 200 µM -0.372726223649403 0.352558620480593 no 2164 0.354676108490154 3025 894453
SGTC_3153 9100258 49.47 µM -0.373578437391108 0.35225245054138 no 2165 0.354358989370277 3056 25236848
SGTC_2440 5628896 157.78 µM -0.374183484342806 0.352035136893049 no 2166 0.354133905288686 3050 5522048
SGTC_2280 7785178 200 µM -0.374726093187183 0.351840290121828 no 2167 0.353932092200725 3059 2954328
SGTC_283 0987-0079 11.7 µM -0.37532675277106 0.351624643136823 no 2168 0.353708736090903 3172 411556
SGTC_2452 5863136 48.41 µM -0.376219422976913 0.351304247588414 no 2169 0.353376888455586 3031 2184096
SGTC_724 3910-0327 137 µM -0.376398745269798 0.351239898295965 no 2170 0.35331023933127 3149 2885483
SGTC_2379 9035213 200 µM -0.377154677549647 0.350968681055921 no 2171 0.353029329734895 3215 646551
SGTC_1606 st000094 49.2 µM -0.377492725379328 0.350847419085596 no 2172 0.352903734757007 3204 1242210
SGTC_511 blebbistatin 171 µM -0.377652673496797 0.350790048995588 no 2173 0.352844314785469 3218 3476986 A myosin inhibitor.
SGTC_1730 st033808 45.1 µM -0.377932029836403 0.350689857799972 no 2174 0.352740543831643 3057 1045166
SGTC_222 nsc-310342 10.666 µM -0.379811808767308 0.350015945114672 no 2175 0.352042557979064 3169 432556
SGTC_2848 9016370 25.97 µM -0.380010915675375 0.349944591639062 no 2176 0.351968656188978 3204 7894410
SGTC_713 1488-1073 324 µM -0.380570885348621 0.349743945032826 no 2177 0.351760844256803 3100 3312542
SGTC_289 k017-0060 526 µM -0.381247752124353 0.349501468233353 no 2178 0.351509709427548 3085 5512909
SGTC_2191 5911152 200 µM -0.381475429729822 0.349419920132329 no 2179 0.35142524979063 3122 2875902
SGTC_596 1155-0152 116 µM -0.382196612231601 0.349161657507917 no 2180 0.351157767247946 3111 280313
SGTC_3314 9135860 59.4275 µM -0.382826245126998 0.348936236805369 no 2181 0.350924300210477 3213 25252478
SGTC_1389 3405-0187 19 µM -0.383010963936409 0.348870114023605 no 2182 0.35085581739421 3106 799890
SGTC_1040 k898-0338 155 µM -0.383190340436117 0.348805907991506 no 2183 0.350789319827376 3270 20969351
SGTC_571 k831-0106 44.2 µM -0.383515862993466 0.348689401491953 no 2184 0.350668655393091 3203 4783639
SGTC_1251 0490-5699 265 µM -0.386653513817945 0.347567150226309 no 2185 0.349506367500728 3259 3883818
SGTC_477 mead ethanolamide 10 µM -0.38705080889443 0.347425143717408 no 2186 0.349359296799169 3115 16061185
SGTC_3284 9108171 64.8615 µM -0.388313765884842 0.346973863078886 no 2187 0.348891925646909 3155 8687505
SGTC_278 4092-0821 23.9 µM -0.38848781376129 0.346911689170701 no 2188 0.348827535263738 3166 877900
SGTC_2182 6325192 200 µM -0.388697495953552 0.346836791338457 no 2189 0.348749967466751 3183 736248
SGTC_1443 4112-3303 14 µM -0.388732311135698 0.346824356042058 no 2190 0.348737088887747 3098 704433
SGTC_2415 st077333 57.7 µM -0.389848577159616 0.346425735356273 no 2191 0.348324260333034 3316 2766255
SGTC_969 1313-0238 134 µM -0.39014371544838 0.346320369323381 no 2192 0.348215139373371 3081 5212874
SGTC_697 0508-1955 564 µM -0.391196145380083 0.345944742767596 no 2193 0.347826128645792 3250 6243113
SGTC_2568 diosmetin 100 µM -0.39141346797248 0.345867196245808 no 2194 0.347745819413262 3254 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_810 3825-7150 143 µM -0.393936875244755 0.344967251035021 no 2195 0.346813822309979 3258 22330411 YGL099W LSG1
SGTC_2118 5526350 200 µM -0.394568977593964 0.344741955789882 no 2196 0.34658050599831 3179 743594
SGTC_2347 9049783 174.81 µM -0.395058481579283 0.344567523569198 no 2197 0.346399864368753 3243 6467988 YPL169C MEX67
SGTC_1970 st070122 35.8 µM -0.397691281328661 0.343629906607211 no 2198 0.345428882493099 3264 102928
SGTC_658 3253-0951 102 µM -0.397904952949517 0.343553853990103 no 2199 0.345350124470348 3146 1184878
SGTC_2606 farnesol 9.78 µM -0.398405098483874 0.343375860837566 no 2200 0.345165800140058 3254 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1677 st019204 53.9 µM -0.398469709194528 0.343352869534609 no 2201 0.345141991096715 3179 3945625
SGTC_982 1491-0518 27.5 µM -0.398829584385681 0.343224820886914 no 2202 0.345009388326121 3098 3091256
SGTC_2203 7227154 166.4 µM -0.399211291649738 0.343089023749096 no 2203 0.344868761916471 3152 896304
SGTC_1724 st037281 8.293 µM -0.399268286021769 0.343068749025948 no 2204 0.344847766213658 3065 574124 YDL195W SEC31
SGTC_1142 3253-1408 9.78 µM -0.400104622097367 0.342771289487129 no 2205 0.34453973000146 3234 256655
SGTC_877 0771-0151 33.1 µM -0.402189600433968 0.342030150158034 no 2206 0.343772247594682 3178 6166523
SGTC_38 0929-0051 58.268 µM -0.402772532459675 0.341823046201296 no 2207 0.343557784743357 3230 1379719
SGTC_866 0495-0101 262 µM -0.403671583401566 0.341503724913012 no 2208 0.343227119298864 3101 635694
SGTC_2671 danthron 100 µM -0.40457529068052 0.341182864097994 no 2209 0.342894862199923 3178 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1751 st044839 27.194 µM -0.404989834903842 0.341035718773084 no 2210 0.342742491455531 3197 5291326
SGTC_2784 7567673 72.73 µM -0.405366250529479 0.340902128396933 no 2211 0.342604157495909 3198 3471247
SGTC_3204 9114183 49.47 µM -0.406059861260894 0.340656017332783 no 2212 0.342349308599713 3058 17027248
SGTC_1642 st009582 77.7 µM -0.406300263721083 0.340570732130989 no 2213 0.342260995824258 3265 6739311
SGTC_464 bw-b 70c 158 µM -0.407151448489581 0.340268831280462 no 2214 0.341948379166336 3225 5353454
SGTC_3009 9080819 71.4286 µM -0.409505274578018 0.339434502341364 no 2215 0.341084448381944 3189 17027216
SGTC_3267 9137951 49.47 µM -0.41066780885649 0.339022724365668 no 2216 0.340658067277383 3061 16643986
SGTC_2013 4024628 200 µM -0.410841394556595 0.33896125555026 no 2217 0.340594418938912 3263 5230760
SGTC_1508 1080-0625 72.9 µM -0.41128644053237 0.338803678927624 no 2218 0.34043125551798 3132 767111
SGTC_3078 9116413 49.47 µM -0.412193808823401 0.338482496081795 no 2219 0.340098687336909 3055 17177322
SGTC_2357 9067248 200 µM -0.413196370459443 0.338127754057339 no 2220 0.339731373562775 3210 9150235
SGTC_2404 5161160 200 µM -0.41385567293459 0.337894547637354 no 2221 0.339489904348755 3116 2831543
SGTC_2073 5212005 126 µM -0.413925101166615 0.33786999331806 no 2222 0.339464480124594 3151 691789
SGTC_2441 5730946 39.09 µM -0.415873906247921 0.337181051436356 no 2223 0.33875113723091 3258 1774275
SGTC_2679 rapamycin 1 nM -0.415890203687739 0.337175292260461 no 2224 0.338745174130469 3202 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2698 st077697 67.5 µM -0.416044456165439 0.337120784536509 no 2225 0.338688736407509 3155 3154499
SGTC_2307 7538926 6.34 µM -0.41618133227238 0.33707241991049 no 2226 0.338638659364306 3158 96582
SGTC_2813 7971799 71.43 µM -0.416924890412473 0.336809733678794 no 2227 0.338366673482139 3212 2234054
SGTC_2016 5121758 140 µM -0.41772047436925 0.336528755760536 no 2228 0.338075750456279 3153 2795203
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.417724613953695 0.336527294014032 no 2229 0.338074236977524 3168 6708561
SGTC_1072 oxiconazole 14.9 nM -0.417842729705582 0.336485586692778 no 2230 0.33803105362944 3207 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1046 2001-0062 216 µM -0.417859907266187 0.336479521369251 no 2231 0.338024773657447 3112 739778
SGTC_230 MPP+ 141.667 µM -0.417881917198622 0.336471749817989 no 2232 0.338016727076751 3190 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2850 9015429 58.44 µM -0.418714957337492 0.336177660629127 no 2233 0.337712231525036 3180 6457570
SGTC_1108 betulinic acid 729.144 nM -0.419752333018864 0.335811574751547 no 2234 0.33733319505595 3190 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3263 9137018 49.47 µM -0.420011826072078 0.335720024991946 no 2235 0.337238407236283 3198 43844957
SGTC_1837 st055472 66.5 µM -0.420594252669139 0.335514579023288 no 2236 0.337025695627998 3314 676091
SGTC_1506 4226-2149 212 µM -0.420759925590193 0.335456148306133 no 2237 0.336965198714405 3226 991114
SGTC_2076 5212012 200 µM -0.421579879147081 0.335167019799692 no 2238 0.336665847623643 3162 604802
SGTC_3110 9122132 49.47 µM -0.422426695889309 0.334868521390299 no 2239 0.336356797843367 3312 918317
SGTC_2676 harmalol 100 µM -0.422695627533596 0.334773746224339 no 2240 0.33625867308305 3236 5459187 A monoamine oxidase inhibitor
SGTC_952 1185-0122 232 µM -0.423269552279941 0.334571522545242 no 2241 0.336049303170578 3131 678600
SGTC_1330 1469-0054 61.8 µM -0.426280936577386 0.333511242022219 no 2242 0.334951573593978 3279 7102664
SGTC_3130 9127414 49.47 µM -0.42674759084785 0.333347056056712 no 2243 0.334781591531935 3234 1494646
SGTC_2720 fluspirilene 36.88 µM -0.427809534661132 0.332973544581773 no 2244 0.334394897317479 3225 3396 An atypical antipsychotic.
SGTC_2867 9039098 71.43 µM -0.427818334951794 0.332970449997035 no 2245 0.334391693529554 3117 6463460
SGTC_2875 9039966 71.43 µM -0.431789494089965 0.331575172357588 no 2246 0.332947207954067 3207 6463691
SGTC_1178 0988-0033 191 µM -0.43517421583854 0.330387782204349 no 2247 0.331717988323271 3271 5392207
SGTC_3100 9120536 49.47 µM -0.435653398498554 0.330219818270568 no 2248 0.331544110875454 3216 16421196
SGTC_3283 9109332 35.8195 µM -0.437211100823627 0.329674046245989 no 2249 0.330979129946427 3170 17027281
SGTC_923 1900-2434 73.3 µM -0.43861071794199 0.329183971651916 no 2250 0.330471814795539 3151 5910570
SGTC_2949 9072542 2.23 µM -0.439193202755754 0.328980101559237 no 2251 0.330260774918929 3246 16457352
SGTC_1399 3562-5772 25 µM -0.439791407823571 0.328770782306473 no 2252 0.330044095629918 3155 23847490
SGTC_3095 9117207 49.47 µM -0.441185297802298 0.328283251637998 no 2253 0.329539427991732 3245 17015229
SGTC_3192 9110362 49.47 µM -0.441345477229119 0.32822724556536 no 2254 0.329481453767651 3266 16649480
SGTC_1394 3474-0001 65.7 µM -0.441671776728325 0.328113168242041 no 2255 0.32936336788271 3213 5017666 YIL048W NEO1
SGTC_1458 k015-0034 6.33 µM -0.442028754425401 0.327988383899056 no 2256 0.329234199229386 3226 3598957
SGTC_1182 1222-0449 220 µM -0.44220740407291 0.327925942726225 no 2257 0.32916956437033 3243 658318
SGTC_2399 5884133 200 µM -0.444000595817879 0.327299457561685 no 2258 0.32852107657062 3185 722445
SGTC_990 3985-0011 41.3 µM -0.444081074074546 0.327271352359575 no 2259 0.32849198459514 3211 5399565 YGL099W LSG1
SGTC_2188 6126565 140.678 µM -0.444189299234151 0.327233558726078 no 2260 0.328452864068687 3280 874518
SGTC_1316 1272-0050 65.9 µM -0.44508304204219 0.326921519850711 no 2261 0.328129871658524 3225 7340392
SGTC_521 r062-0005 13.8 µM -0.446335849942172 0.326484321674163 no 2262 0.327677331914969 3206 2832033
SGTC_1059 3448-6867 171 µM -0.446708384812928 0.326354362382081 no 2263 0.327542813499491 3279 3934407
SGTC_2976 9009005 19.48 µM -0.447636441894459 0.326030700105349 no 2264 0.327207799240317 3344 2993148
SGTC_766 1391-0721 126 µM -0.449251373086302 0.325467801204509 no 2265 0.326625165917294 3313 1020919 YIL115C NUP159
SGTC_1022 4477-0945 21.3 µM -0.449511946951353 0.325377013066863 no 2266 0.326531195887597 3192 4648966
SGTC_2425 5628681 7.85 µM -0.452032002304121 0.324499520491359 no 2267 0.325622964012504 3257 5714958
SGTC_1527 coumarin 137 µM -0.452377160123888 0.32437941095329 no 2268 0.325498649004396 3337 323 A hepatotoxic, DNA x-linker.
SGTC_1715 st032160 10.2275 µM -0.452884998063851 0.324202724487002 no 2269 0.325315777015794 3262 5289825
SGTC_2602 kawain 100 µM -0.454086764516809 0.323784764832479 no 2270 0.324883189569351 3281 5369129
SGTC_2164 5685496 200 µM -0.456346737177064 0.322999375941558 no 2271 0.324070330174996 3331 759046
SGTC_282 k297-0036 65.7 µM -0.456444362876421 0.322965466664053 no 2272 0.32403523534629 3314 5061378
SGTC_3323 9138564 53.9225 µM -0.458251562787126 0.32233802044736 no 2273 0.323385859480339 3356 43912313 YNL103W MET4
SGTC_2505 galangin 7.89 µM -0.458474780856925 0.322260555873915 no 2274 0.323305688448419 3119 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_953 1188-0045 9.7 µM -0.458802227434881 0.322146934284989 no 2275 0.323188097537362 3304 6144426
SGTC_2826 7992541 19.48 µM -0.459835258113757 0.321788589086637 no 2276 0.322817236753892 3289 2985066
SGTC_127 0180-0333 59.125 µM -0.460261908520117 0.32164063781902 no 2277 0.322664119488433 3284 771601
SGTC_660 4031-1742 102 µM -0.461465801209507 0.321223311695461 no 2278 0.322232225929574 3259 6738706
SGTC_156 3474-0145 5.642 µM -0.462272836056859 0.320943681556811 no 2279 0.321942838418016 3324 2265471
SGTC_324 1315-0088 19.6 µM -0.463667302453428 0.320460751145214 no 2280 0.321443063481416 3288 6787421
SGTC_292 k038-0015 474 µM -0.465145753572073 0.31994906703148 no 2281 0.320913541349979 3322 46368540
SGTC_1607 st000305 50.6 µM -0.466742405631295 0.319396858685993 no 2282 0.320342093233694 3320 5457690
SGTC_654 1124-0271 80.9 µM -0.467005009198301 0.31930607452053 no 2283 0.320248147108625 3229 5403748
SGTC_2382 9035899 200 µM -0.467558809029562 0.319114656979182 no 2284 0.320050063625939 3222 6462679
SGTC_1339 1486-1321 22.7 µM -0.46757611667207 0.319108675474671 no 2285 0.32004387384332 3242 3469382
SGTC_2872 9044037 25.97 µM -0.468378924661364 0.318831277589007 no 2286 0.319756818355462 3238 6465195
SGTC_3140 9094243 49.47 µM -0.468487495102255 0.31879377053775 no 2287 0.319718005721256 3342 19291112
SGTC_981 1488-1094 54.9 µM -0.468613981030726 0.318750076692187 no 2288 0.319672791004138 3245 3449522
SGTC_1982 st072467 71.9 µM -0.468841370520919 0.318671532620856 no 2289 0.319591513196454 3165 3163533
SGTC_1263 0774-1208 64.8 µM -0.470202846179998 0.318201427025967 no 2290 0.319105050444493 3384 906585
SGTC_2965 9082772 38.63 µM -0.472947073154169 0.31725475962157 no 2291 0.318125469910537 3391 16459634
SGTC_2 0422-0095 29 µM -0.473110331351683 0.317198478534524 no 2292 0.318067233173816 3252 6790840
SGTC_635 k038-0028 24.7 µM -0.473568434778487 0.317040576063144 no 2293 0.317903844583127 3249 4035102
SGTC_2595 hexamethylquercetagetin 100 µM -0.474341261442708 0.316774267972371 no 2294 0.317628286169399 3237 386331
SGTC_2011 4012611 177 µM -0.474590554340407 0.316688384454383 no 2295 0.317539420044996 3211 2049887
SGTC_1277 0873-0036 22 µM -0.474909087942481 0.316578661304395 no 2296 0.317425886795894 3332 5965735
SGTC_2276 7947513 42.08 µM -0.475598165449538 0.3163413545914 no 2297 0.317180341311287 3274 2105100
SGTC_1928 4'-methoxychalcone 40.3 µM -0.476108079911453 0.316165797291176 no 2298 0.31699869047706 3406 641818
SGTC_1713 st033146 12.748 µM -0.476629307453356 0.315986387860534 no 2299 0.31681305506888 3378 674619
SGTC_2830 7992007 71.43 µM -0.476965835497648 0.315870576044859 no 2300 0.316693224959102 3203 1952075
SGTC_312 4092-0653 6.84 µM -0.477038027384792 0.315845734485485 no 2301 0.316667521547802 3315 1148278
SGTC_673 1082-0474 110 µM -0.478292708547464 0.315414125867588 no 2302 0.316220942653384 3259 3098046
SGTC_2038 4100038 30.985 µM -0.478796562133325 0.315240871729068 no 2303 0.316041681321419 3319 3596803
SGTC_775 4577-0580 57.3 µM -0.480808026026354 0.314549618702258 no 2304 0.315326472715067 3433 2006902
SGTC_2306 7482397 179.52 µM -0.480822952465682 0.314544491556638 no 2305 0.315321167958988 3380 891448
SGTC_2006 4011487 200 µM -0.481754167019722 0.314224695489722 no 2306 0.314990295888605 3388 45595294
SGTC_1454 4239-0054 42.6 µM -0.483212323062211 0.313724218216831 no 2307 0.314472493184385 3420 1340767
SGTC_210 3551-0445 56.827 µM -0.483729695966377 0.313546724606901 no 2308 0.314288857604637 3382 2865180 YOR207C RET1
SGTC_2564 betulinic acid 100 µM -0.484126239250779 0.313410712876816 no 2309 0.314148140218662 3457 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1208 2323-2347 50.3 µM -0.485269720244996 0.313018648550425 no 2310 0.31374251576038 3364 5412760
SGTC_1628 st004252 77.7 µM -0.48553273911949 0.312928497380061 no 2311 0.313649247479265 3360 692968
SGTC_1588 farnesol 29.9 µM -0.48566878741021 0.312881870466556 no 2312 0.313601008503646 3282 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3325 9138760 55.175 µM -0.486531085029832 0.312586410649677 no 2313 0.313295335673758 3249 43844959
SGTC_53 0973-0023 39.979 µM -0.489363854616319 0.311616631676064 no 2314 0.312292060591409 3409 674768
SGTC_3158 9100007 49.47 µM -0.489717918673846 0.311495511936903 no 2315 0.312166760176502 3245 19297233
SGTC_1691 st019933 84.6 µM -0.491157906824927 0.311003124939226 no 2316 0.311657383949837 3325 6176082
SGTC_101 0490-5701 117.494 µM -0.49130291572084 0.310953559579816 no 2317 0.311606108970586 3332 4661669
SGTC_2089 5281248 129.67 µM -0.49416974667169 0.30997435571055 no 2318 0.31059315186256 3317 2737878
SGTC_1911 st060208 74.3 µM -0.495195080647578 0.309624465890911 no 2319 0.310231211390256 3334 688783
SGTC_2565 isoliquiritigenin 100 µM -0.497858100503425 0.308716530571051 no 2320 0.309292030634745 3345 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3003 9075612 71.4286 µM -0.500106603793356 0.307950830412581 no 2321 0.308500008226948 3325 6501993
SGTC_1187 1391-0724 117 µM -0.500239889406622 0.307905467830693 no 2322 0.308453087049334 3329 6997986
SGTC_185 k048-0037 25.491 µM -0.500269338335935 0.30789544554347 no 2323 0.308442720422577 3385 6827589
SGTC_2197 6588183 93.1375 µM -0.501001914290607 0.307646175770151 no 2324 0.308184887841748 3298 884136
SGTC_2895 9054447 58.44 µM -0.50173337659622 0.307397373502341 no 2325 0.307927541610629 3300 2697450
SGTC_365 0121-0052 13.6 µM -0.502508888629352 0.307133684760376 no 2326 0.307654800745817 3375 3101739
SGTC_2279 7948423 32.93 µM -0.506387227680836 0.305816474456615 no 2327 0.306292419533235 3435 1247112
SGTC_960 1222-0186 7.7 µM -0.506483115303036 0.305783939600241 no 2328 0.30625876996992 3377 3126296
SGTC_2081 5214970 32.255 µM -0.507382196974998 0.30547895403867 no 2329 0.305943337391763 3368 2063512
SGTC_2805 7950783 58.44 µM -0.507502430150286 0.305438178889399 no 2330 0.305901165851158 3357 1178958 YDL195W SEC31
SGTC_2973 9094665 17.96 µM -0.507965799421006 0.305281057225076 no 2331 0.305738664097793 3430 25237061 YIL048W NEO1
SGTC_361 000s-0510 1.45 µM -0.510827458454432 0.304311506680036 no 2332 0.304735940104845 3326 660
SGTC_3028 9087778 49.47 µM -0.511916933089124 0.303942745600394 no 2333 0.30435457334305 3278 17217395
SGTC_2988 9073640 71.4286 µM -0.512918492246913 0.303603917704635 no 2334 0.304004168667517 3458 9102229
SGTC_2281 7943571 200 µM -0.513724368248324 0.303331412006453 no 2335 0.303722356186799 3473 1244024
SGTC_2563 tomatine 8.54 µM -0.514967373449075 0.302911306250704 no 2336 0.303287909664876 3461 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_519 k048-0011 62.8 µM -0.516737145055691 0.302313616012197 no 2337 0.302669831224385 3354 6836379
SGTC_226 1,3-diallylurea 8.28947 mM -0.517455265268708 0.302071242239209 no 2338 0.302419194596887 3347 74537 YKL182W FAS1
SGTC_686 1319-0111 510 µM -0.519209123565575 0.301479662148464 no 2339 0.301807458715937 3454 4562600
SGTC_99 0109-0120 622.8 µM -0.519267351563086 0.301460030667296 no 2340 0.301787158661067 3461 759414
SGTC_1383 3049-0032 20.7 µM -0.52197259843881 0.300548595832625 no 2341 0.300844704654355 3432 712864
SGTC_2874 9043904 71.43 µM -0.522930788543433 0.300226067109416 no 2342 0.300511209028193 3325 4463428
SGTC_454 lyso-paf C-16 6.67 µM -0.523202680765485 0.300134576146991 no 2343 0.30041660805103 3346 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1217 1183-1422 255 µM -0.523811654448108 0.299929703990123 no 2344 0.300204773271073 3407 2849664
SGTC_2612 dictamnine 15.46 µM -0.524473118639623 0.29970724460924 no 2345 0.299974755934446 3338 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.524893426688697 0.29956592815474 no 2346 0.299828639604373 3395 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2318 6029776 164 µM -0.529610505285049 0.297982022226039 no 2347 0.298191004574504 3454 818325
SGTC_2496 diffractaic acid 79.83 µM -0.531061519802496 0.297495567761658 no 2348 0.29768807431137 3506 94870 An apoptosis inducer which activates caspases.
SGTC_188 3229-0966 278.469 µM -0.532226440040965 0.297105289380401 no 2349 0.297284586344911 3452 5722370
SGTC_2882 9058044 58.44 µM -0.532472875692894 0.297022757079541 no 2350 0.297199261617649 3373 18076804
SGTC_1825 st052143 62.6 µM -0.533151345168011 0.296795589090539 no 2351 0.296964409373044 3454 674173
SGTC_2768 sulfasalazine 50.2 µM -0.533359625822026 0.296725867648685 no 2352 0.296892330049572 3484 5384001 An antioxidant and salicylic acid derivative.
SGTC_3320 9137005 35.139 µM -0.535735227963921 0.295931171739538 no 2353 0.296070776565447 3363 4908713
SGTC_1310 1188-0297 994 nM -0.538091837870891 0.295143796181683 no 2354 0.29525682357228 3381 1588352
SGTC_1152 3909-8331 15.9 µM -0.538249032902107 0.295091309510715 no 2355 0.295202566408836 3343 16001939
SGTC_1313 1220-0047 237 µM -0.539285830029859 0.294745235624811 no 2356 0.294844822347701 3386 3528706
SGTC_1115 galangin 695.678 nM -0.539945801309202 0.294525040464793 no 2357 0.294617205173417 3490 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1678 st019265 80.2 µM -0.539955068671606 0.294521949009649 no 2358 0.294614009534507 3494 5367020
SGTC_2359 9039622 200 µM -0.541460005775817 0.294020123021254 no 2359 0.294095278523961 3385 6463596
SGTC_2389 9091542 195.52 µM -0.542383994558222 0.293712212051958 no 2360 0.29377700165985 3359 3626624 YOL127W RPL25
SGTC_2783 7738165 71.43 µM -0.542610768772643 0.293636664394193 no 2361 0.293698911454831 3348 17201110
SGTC_2929 9013348 24.6 µM -0.542723300757752 0.293599178780842 no 2362 0.293660164382336 3380 2995952
SGTC_2361 9034121 116 µM -0.543340426357489 0.293393647014807 no 2363 0.293447717451148 3347 6496917
SGTC_1429 4049-0205 9.46 µM -0.543515896532905 0.293335219391709 no 2364 0.293387324435072 3457 22774478
SGTC_1906 st060206 94.7 µM -0.544088536119154 0.293144580806752 no 2365 0.293190274424672 3441 5133468
SGTC_3162 9099653 49.47 µM -0.546334569916779 0.292397404412039 no 2366 0.292417988628808 3432 25237511
SGTC_2695 st077686 51.995 µM -0.546540366946987 0.292328987288473 no 2367 0.292347273827485 3385 2876092
SGTC_2620 irigenin 100 µM -0.547473265109101 0.292018939150268 no 2368 0.292026816457393 3477 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_598 3937-0236 20.2 µM -0.548513135940967 0.291673519253465 no 2369 0.291669806045739 3434 1379313
SGTC_1709 st033179 39.1045 µM -0.549696405254786 0.2912806976696 no 2370 0.291263811432008 3398 573381
SGTC_1246 0422-0085 105 µM -0.550295531002426 0.291081894200315 no 2371 0.291058344484988 3478 264295
SGTC_647 0140-0236 81 µM -0.550889852413813 0.290884747556748 no 2372 0.290854592077062 3411 990837
SGTC_1884 5633444 25 µM -0.551470689242668 0.290692134304032 no 2373 0.290655527061328 3473 5724239
SGTC_896 0964-0007 44.5 µM -0.552510757614632 0.290347382858013 no 2374 0.290299233041518 3443 6756758
SGTC_1583 clindamycin 39.6 µM -0.553171601671491 0.290128432408378 no 2375 0.290072955419546 3364 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2148 5546263 113.568 µM -0.553614348430773 0.289981785120073 no 2376 0.289921402097182 3351 792097
SGTC_429 1112-0049 25.5 µM -0.553909054427775 0.28988419139888 no 2377 0.289820544086555 3295 2836170
SGTC_942 3253-1115 227 µM -0.554799057440253 0.289589554922357 no 2378 0.289516055963454 3503 46497897
SGTC_146 3448-8650 53.125 µM -0.558416484647212 0.28839345110899 no 2379 0.288280009386515 3409 2891488 YIL048W NEO1
SGTC_679 0422-0091 41.4 µM -0.558793900011685 0.288268792850715 no 2380 0.288151193013439 3413 627384 YHR062C RPP1
SGTC_2654 protoveratrine a 100 µM -0.559030125019218 0.288190781938298 no 2381 0.288070580417143 3400 5702278 A heart drug and vasodilator.
SGTC_1819 st053448 58.6 µM -0.560001902025285 0.287869967240196 no 2382 0.287739070171659 3370 2857616
SGTC_256 clotrimazole 625 nM -0.564081478752615 0.286525011933653 no 2383 0.286349341120024 3441 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3342 9147791 14.508 µM -0.564132378111614 0.286508250273386 no 2384 0.286332022131822 3434 1838168
SGTC_2339 9000433 200 µM -0.564810603715498 0.286284948313741 no 2385 0.28610129692919 3374 2988954
SGTC_663 1486-0733 13.9 µM -0.567091402808538 0.285534614893796 no 2386 0.285326041787412 3405 722445 YPR165W RHO1
SGTC_1668 st014914 51.6 µM -0.56790985492806 0.285265590315676 no 2387 0.285048089946861 3484 2839556
SGTC_2431 5490079 200 µM -0.569148130885598 0.284858799683881 no 2388 0.284627808688465 3421 5722345
SGTC_2713 st079149 53.4 µM -0.569446947853513 0.28476067567896 no 2389 0.284526432031356 3455 3103253
SGTC_1791 st048313 56.1 µM -0.569682586583067 0.284683309201975 no 2390 0.284446501389777 3448 1204976
SGTC_2474 5321570 43.32 µM -0.570644591792305 0.284367561390896 no 2391 0.284120292465794 3445 2841384
SGTC_3098 9119039 49.47 µM -0.573781272579359 0.283339209088384 no 2392 0.283057911548354 3484 17161528
SGTC_3296 9122258 64.045 µM -0.577143470156749 0.282238905741763 no 2393 0.281921270479387 3466 4730474
SGTC_1186 1319-0216 26 µM -0.578923543650065 0.281657197626232 no 2394 0.281320381649532 3539 4565136
SGTC_2106 5357045 167.29 µM -0.579552757889457 0.281451715824185 no 2395 0.281108129523866 3461 668842
SGTC_1575 cyproterone acetate 48 µM -0.580350793321066 0.281191206362451 no 2396 0.280839040460563 3413 9880 An androgen receptor antagonist and liver toxin.
SGTC_294 k038-0071 157 µM -0.582675548208713 0.280432981322305 no 2397 0.280055868396457 3479 24152826
SGTC_466 geldanamycin 89.2 µM -0.583502651657663 0.280163458235407 no 2398 0.279777486256104 3405 5288382 HSP90 inhibitor.
SGTC_1171 0368-0077 21.4 µM -0.584293230754151 0.279905954493442 no 2399 0.279511522842305 3446 3239779
SGTC_1796 st049173 110.4 µM -0.585005783388886 0.279673963554671 no 2400 0.279271914013769 3476 94134
SGTC_930 2810-3379 265 µM -0.58530155123476 0.279577695681227 no 2401 0.279172486000327 3561 1015764
SGTC_870 0573-2213 57.6 µM -0.585320148996681 0.279571642934089 no 2402 0.279166234582328 3506 3916321
SGTC_2161 5662504 8.5105 µM -0.58595209260823 0.279366011116142 no 2403 0.278953854652875 3457 2859334
SGTC_973 1325-0077 65.9 µM -0.586668519764673 0.279132977608309 no 2404 0.278713177085868 3497 2835149
SGTC_2151 5563267 85.4165 µM -0.586964344266839 0.279036781832977 no 2405 0.278613826875905 3440 5310824
SGTC_2308 7584454 197.62 µM -0.587753320855658 0.278780302456203 no 2406 0.278348939987369 3566 893577
SGTC_1562 morin hydrate 59.1 µM -0.588226237555951 0.278626622395626 no 2407 0.278190224258371 3539 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3242 9133940 49.47 µM -0.588643287235823 0.278491131247177 no 2408 0.278050294708836 3549 17248444
SGTC_752 1896-0090 130 µM -0.588748669836593 0.27845689961651 no 2409 0.278014941911092 3505 772567
SGTC_3128 9127691 49.47 µM -0.589553794609818 0.278195437090595 no 2410 0.277744918375205 3480 41316314
SGTC_1147 3809-1045 12.3 µM -0.58976268629851 0.278127619532724 no 2411 0.277674881007285 3445 325925
SGTC_2706 st078239 82.5 µM -0.590676025308569 0.277831194955435 no 2412 0.277368757350871 3518 15434492
SGTC_159 3970-0959 50 µM -0.590740880568097 0.277810152018946 no 2413 0.277347026102562 3605 6615653
SGTC_523 1934-0222 13.7 µM -0.593283685640181 0.276985727455124 no 2414 0.276495657538662 3477 1361595
SGTC_1459 k035-0031 35.7 µM -0.593365014591107 0.276959378879746 no 2415 0.27646844857059 3444 3877128 YMR208W ERG12
SGTC_1058 3448-5425 97.3 µM -0.593832255666658 0.276808028068954 no 2416 0.276312156401044 3479 7279705
SGTC_630 4356-0227 183 µM -0.59459635913082 0.276560603603897 no 2417 0.276056657186923 3513 779312
SGTC_800 3448-7362 155 µM -0.595440644045329 0.276287341708489 no 2418 0.275774482043799 3564 15991913
SGTC_252 miconazole 1.30953 nM -0.595648456851154 0.276220101180485 no 2419 0.275705049026197 3471 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_997 3996-0078 137 µM -0.597079110376043 0.275757412750537 no 2420 0.275227282029083 3476 735687
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.598517801581748 0.275292509300282 no 2421 0.27474724223311 3467 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1496 4469-0713 57.4 µM -0.599568866742789 0.274953108661597 no 2422 0.274396800537178 3524 746691
SGTC_326 k292-0812 17.5 µM -0.601166529670502 0.274437600725684 no 2423 0.273864537455 3498 3579357
SGTC_170 4197-0004 226 µM -0.601919067549278 0.274194949385386 no 2424 0.27361400564085 3524 218692
SGTC_1845 st056753 3.01 µM -0.602404693577148 0.274038418450757 no 2425 0.273452393247763 3450 5375839
SGTC_2894 9048625 32.47 µM -0.603034014079577 0.273835636454553 no 2426 0.273243030827952 3598 4092861
SGTC_284 0988-0104 32.6 µM -0.603707587214628 0.273618677448468 no 2427 0.273019034452048 3519 4666532
SGTC_1741 st038134 10.228 µM -0.604580040238514 0.273337785397307 no 2428 0.272729036058164 3601 1272587
SGTC_3083 9117465 49.47 µM -0.607856808102061 0.272284085310145 no 2429 0.271641224074866 3527 16420915
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.609404501306814 0.271787101131287 no 2430 0.271128177508651 3545 4213774
SGTC_1052 3253-3998 198 µM -0.612332116869064 0.270848242444666 no 2431 0.270159022306089 3509 5450317
SGTC_1240 0356-0016 42.1 µM -0.612409386622465 0.270823484706173 no 2432 0.270133466485858 3482 4305613
SGTC_2725 haloperidol 53.21 µM -0.612791756200018 0.270700987600039 no 2433 0.270007021242662 3511 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_963 1269-2853 151 µM -0.613151972032933 0.270585613050411 no 2434 0.269887929088517 3499 3668223
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.613323953472522 0.270530537292281 no 2435 0.269831079008473 3475 803109
SGTC_781 4335-2806 94.4 µM -0.613800218166298 0.270378046354252 no 2436 0.26967367653926 3591 845254
SGTC_143 4032-1194 15.74 µM -0.614121786346198 0.270275110613742 no 2437 0.269567426306628 3543 1806963
SGTC_2832 7992762 51.95 µM -0.616070996694409 0.269651577332225 no 2438 0.268923831592017 3376 2985177
SGTC_1882 5615643 20 µM -0.618344636915785 0.268925173779667 no 2439 0.268174091924204 3501 2253075
SGTC_3113 9123498 49.47 µM -0.618425819808032 0.268899254898117 no 2440 0.268147341084607 3580 8897275
SGTC_1013 4112-3890 241 µM -0.618633293115881 0.268833021566753 no 2441 0.268078981980401 3473 705171
SGTC_1116 jasmonic acid 1.58368 µM -0.618657788454443 0.268825202268497 no 2442 0.268070911740971 3584 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2951 9072950 58.06 µM -0.619400634334442 0.268588128420733 no 2443 0.267826231684739 3578 16488155
SGTC_260 nsc-65238 3.989 µM -0.619410584831653 0.268584953505415 no 2444 0.267822954933902 3503 3246252
SGTC_1842 st055362 61.2 µM -0.620053789113516 0.268379765682719 no 2445 0.267611187250804 3531 676032
SGTC_3072 9116419 49.47 µM -0.62136702326263 0.267961077374969 no 2446 0.267179082123776 3504 17170162
SGTC_2372 9071633 200 µM -0.622857645736081 0.26748623260258 no 2447 0.266689036444 3585 21321366
SGTC_2094 5332512 191.667 µM -0.623253436245064 0.267360223011798 no 2448 0.266558995752531 3577 755774
SGTC_2930 9013230 14.89 µM -0.623461726606697 0.267293920708653 no 2449 0.266490572877147 3544 2995857
SGTC_652 0437-0092 114 µM -0.624599159525441 0.266932003215988 no 2450 0.266117085721993 3552 3091274
SGTC_832 4083-0019 164 µM -0.624613091073923 0.266927571899579 no 2451 0.26611251280632 3633 1990758
SGTC_236 1509-0011 5.31 µM -0.626573173300466 0.266304483874046 no 2452 0.26546952890345 3628 3107280
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.629368004206542 0.265417313550761 no 2453 0.264554079931601 3535 5379071
SGTC_32 0928-0142 34.1 µM -0.629927668612403 0.265239838254502 no 2454 0.264370954636945 3543 2244242
SGTC_373 0844-0104 25.9 µM -0.630400484950529 0.265089950334243 no 2455 0.264216296811177 3577 5375804
SGTC_3350 9150499 3.57 µM -0.630495779255014 0.265059746213973 no 2456 0.264185131704671 3551 4910996 YPR165W RHO1
SGTC_516 3992-2719 87.3 µM -0.631233601633293 0.264825948023806 no 2457 0.263943897216573 3491 5350887 YDR037W KRS1
SGTC_754 3474-0146 171 µM -0.631952815541711 0.264598147356275 no 2458 0.26370885496663 3493 24762078
SGTC_3220 9131269 49.47 µM -0.632817472581741 0.26432441168587 no 2459 0.263426422658204 3608 17722206
SGTC_452 diindolylmethane 8 µM -0.633083942684697 0.264240080868762 no 2460 0.263339413775006 3552 3071 Inhibits expression of several cancer promoting factors.
SGTC_2468 5987765 72.9 µM -0.634585971926663 0.263764984326717 no 2461 0.262849239821713 3560 26772094
SGTC_2897 9048598 12.99 µM -0.634834633835964 0.263686373837363 no 2462 0.262768136245149 3531 6467404
SGTC_1864 st057645 30.4 µM -0.635185001168678 0.263575631089359 no 2463 0.262653882151958 3605 688666
SGTC_1574 spiramycin 23.7 µM -0.635876364383892 0.26335717732437 no 2464 0.262428504566495 3584 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3036 9090181 49.47 µM -0.638004714957501 0.262685251758069 no 2465 0.261735305432043 3592 25236586
SGTC_2528 xanthyletin 44.79 µM -0.639517047967474 0.262208338067548 no 2466 0.261243313432279 3597 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_280 3448-3607 3.04 µM -0.639914293926638 0.262083140297983 no 2467 0.261114160267176 3573 626179
SGTC_359 0081-0058 15.9 µM -0.640836975183652 0.261792462321327 no 2468 0.260814303532238 3693 3494159
SGTC_2969 9091408 28.7 µM -0.641120366502947 0.261703217012233 no 2469 0.260722241433761 3495 4286311
SGTC_3299 9121982 43.1275 µM -0.641153089362378 0.261692912967701 no 2470 0.260711612209496 3557 17594604 YPL160W CDC60
SGTC_932 2857-0803 154 µM -0.641685967959684 0.261525145051736 no 2471 0.260538550959204 3650 674898
SGTC_485 niflumic acid 177 µM -0.642556326937597 0.261251245872087 no 2472 0.260256014554333 3596 4488 A COX2 inhibitor.
SGTC_2235 salicylic acid 500 µM -0.642776586600555 0.261181954238517 no 2473 0.260184538784071 3588 338 A COX inhibitor and kinase inhibitor.
SGTC_2275 7947463 200 µM -0.643072107360802 0.261089001005135 no 2474 0.26008865616784 3549 1225414
SGTC_1414 3917-0015 5.4 µM -0.643363556205511 0.260997345212042 no 2475 0.25999411254213 3570 6618702
SGTC_691 1548-0686 185 µM -0.643629458838396 0.260913737710614 no 2476 0.259907871362333 3550 46495133
SGTC_610 4215-0184 155 µM -0.645336287410184 0.260377389470814 no 2477 0.259354640935324 3601 5605015
SGTC_1325 1431-0015 227 µM -0.646593193554833 0.259982786804944 no 2478 0.258947632160443 3535 1103340
SGTC_3143 9086658 49.47 µM -0.64838680115778 0.259420222537349 no 2479 0.258367402476557 3625 25236626
SGTC_1948 st076329 66.6 µM -0.649308392813133 0.259131410451577 no 2480 0.258069531008079 3512 24208413
SGTC_820 1582-0060 59.9 µM -0.652097043309001 0.258258505595311 no 2481 0.257169285663842 3565 3848840
SGTC_2490 carminic acid 95.39 µM -0.652281580000211 0.258200795633221 no 2482 0.257109770309888 3561 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2770 toltrazuril 17.5 µM -0.652935123288211 0.257996467514448 no 2483 0.256899052172775 3601 68591 Kills coccidiodes.
SGTC_3345 9148410 3.559 µM -0.653131322823307 0.257935142760511 no 2484 0.256835810247978 3574 4903596
SGTC_175 3793-3120 23.7 µM -0.655632103146855 0.257154153874225 no 2485 0.25603043227713 3595 5322297
SGTC_1032 k061-1018 98.7 µM -0.656772786879835 0.256798329310073 no 2486 0.255663512314469 3691 4005393
SGTC_2982 9019404 25.97 µM -0.657855010831107 0.256460977735457 no 2487 0.255315650931629 3503 22333232
SGTC_1699 st031318 29.054 µM -0.658298072226247 0.256322932985334 no 2488 0.255173308243804 3629 5340658
SGTC_3104 9120930 49.47 µM -0.660455692856434 0.255651236523372 no 2489 0.254480721318589 3618 17014836
SGTC_1180 1193-0155 285 µM -0.660681589451166 0.255580965055651 no 2490 0.254408266487381 3609 2921347
SGTC_79 0052-0007 94.094 µM -0.660922293329492 0.255506098471611 no 2491 0.254331074217579 3658 2801472
SGTC_513 4245-1575 41.7 µM -0.661313977756592 0.255384296616511 no 2492 0.254205489653214 3600 719745
SGTC_2940 9060638 45.86 µM -0.664720736888463 0.254326180067152 no 2493 0.253114563927 3604 4027022
SGTC_1105 epirubicin 18.1 µM -0.664846978759154 0.25428701439349 no 2494 0.253074185633413 3582 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2149 5554786 194.827 µM -0.665098107455717 0.254209112842 no 2495 0.252993872531731 3646 745063 YPR165W RHO1
SGTC_2324 6149169 200 µM -0.667317874011146 0.25352107318207 no 2496 0.252284555823924 3553 2888231
SGTC_1816 st051957 91.6 µM -0.667484276639191 0.253469534413462 no 2497 0.252231424870241 3627 674121
SGTC_600 1495-0418 41.6 µM -0.668366933514544 0.253196247109306 no 2498 0.251949698670241 3628 5377768
SGTC_257 daunorubicin 18.5 µM -0.668673850086699 0.253101256240351 no 2499 0.251851776041303 3662 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1373 2887-0003 58.5 µM -0.671790424968637 0.252137737058468 no 2500 0.250858562618412 3618 776948
SGTC_830 4076-0286 57.8 µM -0.672370776670543 0.2519585296533 no 2501 0.250673841061324 3673 6866659
SGTC_587 k089-0003 57 µM -0.673132862718874 0.251723306436662 no 2502 0.250431384292468 3574 9659696
SGTC_3023 9089636 49.47 µM -0.673251341402666 0.251686747576561 no 2503 0.250393701606752 3710 17249241
SGTC_435 c-PAF 6.7 µM -0.673745185340357 0.251534392809263 no 2504 0.250236664667815 3601 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1636 st007707 68.9 µM -0.674432385438859 0.251322467243011 no 2505 0.250018229528599 3657 403051
SGTC_847 0342-0274 5.54 µM -0.674490759476595 0.251304469630455 no 2506 0.249999679274407 3645 18097
SGTC_1051 3253-3903 78 µM -0.674546952875199 0.251287144986166 no 2507 0.249981822679358 3621 5509239
SGTC_1010 4112-3296 15.2 µM -0.675342760818119 0.251041862100666 no 2508 0.249729011204694 3667 704384
SGTC_1735 st034310 56.75 µM -0.675508491143617 0.250990796858035 no 2509 0.249676379246777 3670 871153
SGTC_733 4069-0007 56.1 µM -0.676487737729629 0.25068918117324 no 2510 0.249365514411034 3669 5717425 YNL287W SEC21
SGTC_2138 5575593 77.673 µM -0.677040687556892 0.250518953096037 no 2511 0.24919006972231 3632 762213
SGTC_205 1486-1330 71.903 µM -0.67741427178427 0.250403978199213 no 2512 0.249071572867142 3630 4118834
SGTC_2812 7970281 58.44 µM -0.678728669928079 0.249999679274407 no 2513 0.248654898458315 3661 2233435
SGTC_1206 3978-0017 132 µM -0.679532641693445 0.24975255448135 no 2514 0.248400216287372 3683 3873677
SGTC_1079 idarubicin 2.36 µM -0.68054001983341 0.249443089835677 no 2515 0.248081295399348 3621 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3225 9130819 49.47 µM -0.680906748512825 0.249330482102473 no 2516 0.247965248828611 3651 4547121
SGTC_42 0133-0086 60.653 µM -0.681552163833744 0.24913236648293 no 2517 0.247761085829615 3596 162923 Model of phenazepam hydroxylation.
SGTC_2113 5491891 107.031 µM -0.683189539478124 0.248630136271637 no 2518 0.247243540849339 3658 789979
SGTC_1748 st037455 53.6035 µM -0.685182100122506 0.248019688810821 no 2519 0.246614508863483 3645 580690
SGTC_3291 9121177 71.43 µM -0.685801952182021 0.247829952096011 no 2520 0.246419002557371 3614 17015612
SGTC_2922 7999257 32.47 µM -0.686533926093737 0.247605994698676 no 2521 0.24618823911929 3636 2988377
SGTC_500 h-89 112 µM -0.689174492984001 0.246798976504259 no 2522 0.245356733122027 3685 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1856 st057054 55.7 µM -0.689859790403271 0.246589764177116 no 2523 0.245141182142622 3713 1266018
SGTC_631 k072-0230 41.5 µM -0.690460440395306 0.246406471752667 no 2524 0.244952339638642 3673 5773147
SGTC_908 3448-7491 47.7 µM -0.690536108287451 0.246383386361165 no 2525 0.244928555439523 3687 1203031
SGTC_3191 9110352 49.47 µM -0.690622555121957 0.246357013858763 no 2526 0.244901384686048 3641 17122424
SGTC_219 mitoxanthrone 164.414 µM -0.692738178287935 0.245712068510636 no 2527 0.244236937634132 3648 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_849 0386-0493 241 µM -0.693331238682745 0.24553143754227 no 2528 0.244050851594462 3633 726119
SGTC_1877 wortmannin 25 µM -0.693562952470646 0.24546088285746 no 2529 0.243978166962988 3664 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2998 9066762 71.4286 µM -0.69502255525701 0.245016697985101 no 2530 0.243520583262287 3701 4945196
SGTC_1964 st076914 61 µM -0.695352082726025 0.244916476378348 no 2531 0.243417340980494 3698 24208661
SGTC_2321 7390090 138.78 µM -0.696638812784592 0.244525345059683 no 2532 0.24301442984085 3625 649046
SGTC_64 000l-0018 272.079 µM -0.696917097173256 0.244440798369837 no 2533 0.242927338690317 3623 6811119
SGTC_796 1234-0020 70.7 µM -0.697869591368992 0.244151536565947 no 2534 0.242629376463648 3634 46495034
SGTC_716 1683-5115 658 µM -0.697906712561403 0.244140267014347 no 2535 0.242617768103267 3693 723597
SGTC_1391 3442-0225 151 µM -0.69801014527595 0.244108867554684 no 2536 0.242585424709702 3629 5227075
SGTC_2336 9001819 198.65 µM -0.69847712717016 0.243967131214928 no 2537 0.242439428616733 3726 2989602
SGTC_2166 5933061 31.504 µM -0.698963440840785 0.243819574584237 no 2538 0.242287439294086 3849 2877375
SGTC_1418 3966-3099 2.4 µM -0.699158688414996 0.243760346385689 no 2539 0.242226432414094 3670 740335
SGTC_3347 9188721 44.724 µM -0.702298947196233 0.242808819188663 no 2540 0.2412463748493 3698 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_245 methotrexate 289.6 µM -0.702611332843777 0.242714273526776 no 2541 0.241148998990155 3667 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_183 3914-0051 30.55 µM -0.702833831613706 0.242646944899995 no 2542 0.241079655413166 3675 1596232
SGTC_1698 5-fluorocytosine 1.055 µM -0.703302620281752 0.242505121501487 no 2543 0.240933589049702 3702 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1107 amlodipine 47 µM -0.704313494411711 0.242199452960206 no 2544 0.240618782203135 3563 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1071 trifluoperazine 6.31 µM -0.70447838309878 0.242149613669868 no 2545 0.240567453748514 3744 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2001 4023502 57.655 µM -0.705138275093437 0.24195021023772 no 2546 0.24036209462994 3689 108941 YCR052W RSC6
SGTC_2460 5552655 174.22 µM -0.706111774525211 0.24165620490642 no 2547 0.240059314968725 3662 5401989
SGTC_1001 4048-4355 44.4 µM -0.709035899692497 0.240774260956633 no 2548 0.239151099593156 3688 21824233
SGTC_2355 9061122 103.12 µM -0.709324417556049 0.240687336260031 no 2549 0.239061589604949 3692 5302957
SGTC_1602 st001878 87.6 µM -0.709438723267151 0.240652902946214 no 2550 0.239026132385077 3707 595405 YLR310C CDC25
SGTC_3268 9137683 49.47 µM -0.709873245871557 0.240522032358074 no 2551 0.238891371279578 3701 1953228
SGTC_774 k060-0086 136 µM -0.711507281029434 0.240030236689106 no 2552 0.2383849702631 3711 5911235
SGTC_1581 himbacine 57.9 µM -0.712168739073635 0.239831313620447 no 2553 0.238180146209022 3696 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2434 5670830 169.91 µM -0.712314196213163 0.239787581746991 no 2554 0.238135117557764 3694 1549830
SGTC_2849 9019321 12.99 µM -0.712327195066206 0.239783673837122 no 2555 0.238131093775966 3667 16489627
SGTC_2691 st077356 60.2 µM -0.71320919361407 0.239518595408981 no 2556 0.237858159065438 3746 2839272
SGTC_1029 k015-0030 64.7 µM -0.714033996818533 0.239270851475262 no 2557 0.237603078769878 3755 2208316
SGTC_3338 9144300 39.5675 µM -0.714442707003937 0.239148140183507 no 2558 0.237476735879442 3707 4901274
SGTC_2889 9059656 51.95 µM -0.716437599743211 0.238549686797877 no 2559 0.236860592532567 3776 3949838
SGTC_2172 5754775 163.918 µM -0.716554643681006 0.238514599940759 no 2560 0.236824469614215 3663 2263357
SGTC_2407 paclitaxel 400 µM -0.716768764098508 0.238450419285341 no 2561 0.236758394114565 3853 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1141 3253-0389 52.6 µM -0.717224588543457 0.238313821533819 no 2562 0.236617764850898 3667 5402031
SGTC_67 0335-0847 266 µM -0.717425399478301 0.238253657753477 no 2563 0.236555825993022 3807 4552207 YOR254C SEC63
SGTC_1952 st077036 64.1 µM -0.71855496981543 0.237915388930154 no 2564 0.236207583486402 3705 2937007
SGTC_1210 3013-0140 750 nM -0.719265460354395 0.237702755577005 no 2565 0.235988686521462 3732 905973
SGTC_3051 9093778 49.47 µM -0.719267054379477 0.237702278639481 no 2566 0.235988195539649 3724 17217378
SGTC_3172 9105863 49.47 µM -0.721212096753987 0.237120706909071 no 2567 0.235389515133527 3687 2348785
SGTC_777 1315-0167 517 µM -0.722327692907558 0.236787494453954 no 2568 0.235046515369464 3722 4221767
SGTC_1074 carmofur 3.8 µM -0.723746929768836 0.236363961331099 no 2569 0.234610557968463 3738 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1916 st067606 49.2 µM -0.72416891368943 0.236238112049192 no 2570 0.234481020374809 3734 19590279
SGTC_909 3448-9333 149 µM -0.724409799990711 0.236166288495136 no 2571 0.234407092572485 3668 3344074
SGTC_1840 st055363 71 µM -0.725393324059447 0.235873162154066 no 2572 0.234105383740314 3700 676033
SGTC_3279 9140807 49.47 µM -0.725722178490215 0.235775196198802 no 2573 0.234004551350391 3752 45595718
SGTC_1056 3448-1962 115 µM -0.729795336769271 0.234563661273727 no 2574 0.232757647666496 3739 715507
SGTC_1098 clofazimine 15.1 µM -0.730280297043203 0.23441964269011 no 2575 0.232609434606468 3778 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_279 1273-0055 2.93 µM -0.730674974936956 0.234302471374355 no 2576 0.232488852289411 3759 2847562
SGTC_747 3448-8087 38.7 µM -0.731501978669787 0.234057057043439 no 2577 0.232236298189766 3757 5168703
SGTC_1 0258-0098 57.368 µM -0.732322647946818 0.233813663272377 no 2578 0.231985829521621 3664 6790032 YDR047W HEM12
SGTC_52 0329-0193 875 nM -0.732875564898816 0.233649758500825 no 2579 0.231817163838626 3795 3739292
SGTC_403 arphamenine a 50 µM -0.733377581724837 0.233500997578314 no 2580 0.231664084274562 3689 5487158 An arginine aminopeptidase inhibitor.
SGTC_2301 7769476 200 µM -0.734016212415241 0.233311830283225 no 2581 0.231469428599552 3763 977820
SGTC_1291 0993-0025 5.79 µM -0.734205424695991 0.233255800493303 no 2582 0.231411773904589 3751 4353356
SGTC_3324 9138759 60.749 µM -0.735801613846055 0.232783432200916 no 2583 0.230925719472709 3764 45595710
SGTC_2251 lansoprazole 556 µM -0.736546149952017 0.232563279810441 no 2584 0.230699196398665 3667 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3281 9140613 49.47 µM -0.736579298966514 0.232553480648142 no 2585 0.230689113788936 3681 16013766
SGTC_744 1594-0068 283 µM -0.736993908158253 0.232430937642513 no 2586 0.230563026985764 3748 668392
SGTC_531 3788-1495 174 µM -0.738595925183627 0.231957778834334 no 2587 0.230076199654794 3703 2896655
SGTC_2216 7189485 200 µM -0.740307677580524 0.231452802755072 no 2588 0.229556661711257 3731 731273
SGTC_546 peri-Naphthalide 147 µM -0.741426972665453 0.231122936467506 no 2589 0.229217297593642 3697 223824 A penicillin ester.
SGTC_2833 9001315 45.46 µM -0.741895131114944 0.230985043831583 no 2590 0.229075438011438 3741 2989378
SGTC_2097 5376186 200 µM -0.742448182938996 0.230822205665068 no 2591 0.228907917837014 3683 742755
SGTC_3107 9121808 49.47 µM -0.743629045205714 0.230474732407581 no 2592 0.228550463210627 3666 662681
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.744734419852241 0.230149736788487 no 2593 0.228216143476898 3795 6710655
SGTC_368 fentichlor 4.58 µM -0.745683852978654 0.229870794954988 no 2594 0.227929207756754 3748 7329 A pesticide.
SGTC_1321 1326-2144 215 µM -0.746405539806667 0.229658891267715 no 2595 0.227711236893024 3750 3513030
SGTC_2893 9048488 25.97 µM -0.746492850274075 0.229633262347666 no 2596 0.227684874496425 3744 6467338
SGTC_2158 5657123 3.6195 µM -0.749346904312689 0.228796372357355 no 2597 0.22682407209598 3737 2858827
SGTC_2955 9076254 12.21 µM -0.749436421096244 0.22877015120706 no 2598 0.226797102944689 3704 16459619
SGTC_277 nystatin 15.5 µM -0.750726292318172 0.22839251099832 no 2599 0.226408698150395 3747 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_512 prima-1 270 µM -0.75530037470535 0.227056168017953 no 2600 0.225034386955234 3772 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_589 1227-0070 34.1 µM -0.755417489164546 0.227022010375783 no 2601 0.224999261374923 3787 2841384
SGTC_1279 0874-0590 65.2 µM -0.757423559654058 0.226437369266899 no 2602 0.224398072894077 3805 3523074
SGTC_1228 0124-0032 52.5 µM -0.757433803564414 0.226434386006395 no 2603 0.224395005293207 3830 X1228
SGTC_2617 dihydrotanshinone i 20.83 µM -0.760959415100094 0.225408966650274 no 2604 0.223340654297063 3789 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2035 5154463 94.595 µM -0.76172022147057 0.22518803252241 no 2605 0.223113501891626 3759 2769623
SGTC_2979 9012552 45.46 µM -0.762427100392702 0.224982868616748 no 2606 0.222902568433137 3814 17100905
SGTC_1489 4065-0444 182 µM -0.763281448949163 0.224735044709715 no 2607 0.222647781564056 3729 2877968
SGTC_568 1193-0097 7.48 µM -0.763996704226377 0.224527687190845 no 2608 0.222434603318724 3652 3646150
SGTC_3285 9112818 20.8695 µM -0.764133496436282 0.22448804253979 no 2609 0.222393846352061 3786 17017947 YPR165W RHO1
SGTC_3154 9100113 49.47 µM -0.765932294565467 0.223967090695635 no 2610 0.221858294475526 3801 25237525
SGTC_535 2293-4129 48.2 µM -0.768428652500757 0.223245257196369 no 2611 0.221116281638756 3782 396118 YIL048W NEO1
SGTC_1431 4049-0260 9.09 µM -0.769843994546174 0.222836593385308 no 2612 0.220696219521026 3754 3854841
SGTC_1955 wogonin 32.4 µM -0.769929061437386 0.222812044880937 no 2613 0.220670986922871 3847 5281703 A flavanone.
SGTC_2190 6049624 200 µM -0.771099035380045 0.222474571542016 no 2614 0.220324116166502 3685 2265554
SGTC_3193 9111931 49.47 µM -0.771504174014113 0.222357779238392 no 2615 0.220204074644911 3831 17087244
SGTC_2642 cholecalciferol 100 µM -0.772029192815066 0.222206480237397 no 2616 0.220048568751814 3761 9821465 A vitamin D precursor, similar to steriods.
SGTC_1980 st071811 45.7 µM -0.772502218647351 0.222070214802956 no 2617 0.219908516678791 3903 4974850
SGTC_899 1083-0020 478 µM -0.773456064345503 0.22179558381939 no 2618 0.219626260528976 3836 767123
SGTC_1398 3558-0053 112 µM -0.776699152302634 0.220863287394253 no 2619 0.218668143557236 3708 4532369
SGTC_1472 k841-0093 193 µM -0.776814380458801 0.220830203873219 no 2620 0.218634145613002 3887 X1472
SGTC_1191 1487-1166 10.6 µM -0.77782006484926 0.220541579122554 no 2621 0.218337548708792 3867 3955771
SGTC_901 1112-0062 60.1 µM -0.778982384126234 0.220208270625004 no 2622 0.217995045893952 3789 1908457
SGTC_1600 coumarin 106 71.1 µM -0.783645641999083 0.218873935425873 no 2623 0.216624033228644 3903 100336 A hepatotoxic, DNA x-linker.
SGTC_3165 9101544 49.47 µM -0.783694012810803 0.21886011911899 no 2624 0.216609838242189 3828 5002184
SGTC_458 nppb 133 µM -0.783696688157421 0.218859354965977 no 2625 0.216609053145804 3810 4549 A chloride channel blocker.
SGTC_1412 3909-8563 178 µM -0.78370538922405 0.218856869711228 no 2626 0.216606499777409 3889 23767530
SGTC_2485 5633444 17.78 µM -0.785213668022392 0.218426310810344 no 2627 0.216164151528491 3841 5724239
SGTC_2817 7995342 71.43 µM -0.78546205341138 0.218355452603502 no 2628 0.216091355222219 3801 18879975
SGTC_534 k292-0788 63.4 µM -0.787374278586638 0.217810385613903 no 2629 0.215531399619952 3813 4146317
SGTC_2990 9074105 71.4286 µM -0.788523775427499 0.217483107267222 no 2630 0.215195198615958 3760 6502001
SGTC_1648 st011736 69.8 µM -0.78911491743279 0.217314911193738 no 2631 0.215022421960958 3818 2855514
SGTC_1879 gemcitabine 100 µM -0.789715196560835 0.217144192253896 no 2632 0.214847057199568 3802 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1505 k297-0037 20.6 µM -0.789863693286166 0.217101971852636 no 2633 0.214803688382195 3809 4089396
SGTC_2228 7354201 200 µM -0.790534987318483 0.216911169577219 no 2634 0.214607698859493 3835 753451
SGTC_888 0916-0002 6.97 µM -0.794392589591708 0.215816601780404 no 2635 0.21348345843897 3911 2802138 YIL048W NEO1
SGTC_1821 st053465 65.6 µM -0.795634814139505 0.2154648117802 no 2636 0.213122162610738 3826 675086
SGTC_1727 st034309 9.9045 µM -0.795790337885579 0.215420791896784 no 2637 0.213076954313263 3946 870305
SGTC_560 2332-1943 155 µM -0.79598847570348 0.215364717963371 no 2638 0.213019366882335 3800 21177716
SGTC_2883 9059145 45.46 µM -0.796759227700565 0.215146672087256 no 2639 0.212795439355238 3815 16476510
SGTC_3102 9121669 49.47 µM -0.798370025011714 0.214691391249152 no 2640 0.21232789635643 3839 41905072
SGTC_1546 5-methoxyflavanone 78.7 µM -0.798444746162851 0.214670285424194 no 2641 0.21230622270095 3823 147795
SGTC_569 4130-2812 160 µM -0.798714971412164 0.214593967346319 no 2642 0.212227851820292 3681 743552
SGTC_2253 7938677 135.83 µM -0.800195880895078 0.214176003201396 no 2643 0.211798657988983 3887 2301972
SGTC_2959 9079155 11 µM -0.801989732695392 0.213670350778486 no 2644 0.21127944872559 3849 16189457
SGTC_41 0478-0632 82.643 µM -0.80268979743806 0.21347320476746 no 2645 0.211077025692557 3780 3750424
SGTC_1019 4262-0212 3.4 µM -0.803653976475511 0.213201854862971 no 2646 0.210798420440183 3879 4677213
SGTC_622 1348-1566 26.3 µM -0.804049111080329 0.213090709857573 no 2647 0.210684306287031 3887 7340407
SGTC_918 glabranin 770.725 nM -0.804494959542396 0.21296534045479 no 2648 0.210555589591111 3877 124049 Also referred to as licorice root.
SGTC_1363 1636-0063 10.4 µM -0.805079528666984 0.212801029020578 no 2649 0.21038689410297 3841 6072185
SGTC_1883 5-benzylidenerhodanine 20 µM -0.806343119133048 0.212446110377888 no 2650 0.210022517265983 3852 1273210
SGTC_2927 9011802 47.9 µM -0.808943303188561 0.211716856906951 no 2651 0.209273879605073 3863 43912568
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.809262030718813 0.211627566773713 no 2652 0.209182220666116 3822 390807
SGTC_491 tetrandrine 80.3 µM -0.809674168847228 0.211512140753831 no 2653 0.209063733966069 3837 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2687 chenodiol 100 µM -0.810004487876733 0.211419656127257 no 2654 0.208968798197759 3889 5702181 A cholesterol synthesis inhibitor.
SGTC_980 1473-0395 201 µM -0.810006427505462 0.211419113128773 no 2655 0.208968240811255 3757 768876
SGTC_928 2764-0428 58.7 µM -0.810831813165776 0.211188120792035 no 2656 0.208731131177015 3897 662578
SGTC_2371 9071574 200 µM -0.811086793432606 0.211116791953976 no 2657 0.208657914726667 3825 45596039
SGTC_958 1222-0007 33 µM -0.811323041506128 0.211050715911128 no 2658 0.208590090655162 3923 7312461
SGTC_3196 9111891 49.47 µM -0.811549545667691 0.210987376519558 no 2659 0.20852507615302 3843 18891510
SGTC_683 panaxydol 45 µM -0.812444893045978 0.210737111610635 no 2660 0.208268197581616 3817 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1573 oleylamine 1.06 µM -0.812496919599086 0.210722574654195 no 2661 0.208253276707127 3862 5356789 An amine of the fatty acid oleic acid.
SGTC_2984 9022109 38.96 µM -0.812564711653811 0.210703633475778 no 2662 0.208233835336449 3880 6459207
SGTC_1844 rapamycin 4 nM -0.814491941882343 0.210165581046606 no 2663 0.207681593322303 3794 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_189 3970-0742 2.116 µM -0.814817881007223 0.210074663811392 no 2664 0.207588282062598 3819 2891807
SGTC_1102 cgs 12066b 26.1 µM -0.815204135597045 0.20996695214387 no 2665 0.207477735512063 3861 6438352 A 5-HT1B full agonist.
SGTC_2916 7875993 68.79 µM -0.816959815186043 0.209477769279488 no 2666 0.206975696505113 3785 1299250
SGTC_211 3455-0679 143.504 µM -0.817271592825529 0.209390969217078 no 2667 0.206886618480354 3900 748649
SGTC_1865 st057639 52.2 µM -0.817325474539384 0.209375970491331 no 2668 0.206871226229677 3856 688818
SGTC_1708 st033234 31.827 µM -0.819086085525542 0.208886227822463 no 2669 0.206368650037893 3950 674664
SGTC_1140 3229-1848 2.98 µM -0.822943799238775 0.207815504170341 no 2670 0.205269976911896 3888 2849525
SGTC_394 menadione 8.33 µM -0.823050906513101 0.207785822446039 no 2671 0.205239522525346 3837 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1905 st060207 84.5 µM -0.823335193840153 0.207707052470826 no 2672 0.20515870260222 3779 1948547
SGTC_2956 9076196 2.52 µM -0.827064716501051 0.206675315728937 no 2673 0.204100190704816 3874 16423868
SGTC_1643 st009866 20.2 µM -0.827806787155086 0.206470391571498 no 2674 0.203889965164149 3840 3156273 YOR207C RET1
SGTC_2487 5918373 44.05 µM -0.828284661085271 0.206338489562357 no 2675 0.203754653795585 3878 2876279
SGTC_3286 9117135 37.221 µM -0.828938629907578 0.206158063071489 no 2676 0.203569567438783 3846 3438150
SGTC_354 2783-3500 4.88 µM -0.830652869295905 0.205685557778258 no 2677 0.203084879290204 3882 6740761
SGTC_873 0591-4978 488 µM -0.831451877730748 0.205465542451755 no 2678 0.202859201350525 3932 3305145
SGTC_1365 1672-3266 55.4 µM -0.831552160166851 0.205437938508525 no 2679 0.202830887411486 3887 6415873
SGTC_977 1348-1378 135 µM -0.832434152530086 0.20519525441089 no 2680 0.202581965671898 3865 X977
SGTC_1756 st041558 35.5 µM -0.833482940290499 0.20490689764217 no 2681 0.202286207614914 3932 3955792
SGTC_150 3970-0969 77.2 µM -0.83373986548774 0.204836294636539 no 2682 0.202213794135511 3978 6615640
SGTC_1256 0570-0116 285 µM -0.834599931180121 0.204600054006209 no 2683 0.201971500461209 3896 410638
SGTC_1060 3448-7350 82 µM -0.835026976314584 0.204482814602717 no 2684 0.201851259898878 3817 570178
SGTC_1810 st050138 53 µM -0.836214215259744 0.204157084542612 no 2685 0.201517201362877 3831 3444541
SGTC_894 0960-0238 55.9 µM -0.836252905923691 0.204146474600975 no 2686 0.201506320380688 3826 6741907 YDL195W SEC31
SGTC_2036 5160441 105 µM -0.836412386595734 0.20410274450406 no 2687 0.201461473319754 3866 134534 YIL048W NEO1
SGTC_1732 st034308 51.822 µM -0.837653295541206 0.203762674068772 no 2688 0.201112725573874 3760 830119
SGTC_206 4546-0025 72.014 µM -0.837774377728644 0.203729509656997 no 2689 0.201078715771758 3930 6620745 YIL048W NEO1
SGTC_821 1114-0266 29.2 µM -0.839702885926014 0.203201725181183 no 2690 0.20053749774594 3911 3123235
SGTC_1629 st005085 44.9 µM -0.840760994434807 0.202912494397417 no 2691 0.20024092137388 3873 24207091
SGTC_3224 9130643 49.47 µM -0.841684684779452 0.202660207548947 no 2692 0.199982236552682 3894 17644395
SGTC_1940 st075990 51.1 µM -0.842789975548255 0.202358566811526 no 2693 0.199672957698592 3997 1084979
SGTC_1387 3342-1166 1.8 µM -0.844682197961129 0.201842791252191 no 2694 0.199144150749953 3886 3418228
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.845750701056501 0.201551890357979 no 2695 0.198845916276247 3939 5377381
SGTC_107 0358-0022 2.6945 µM -0.846048431753722 0.201470877687051 no 2696 0.198762863372039 3936 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_570 0987-0065 62.6 µM -0.8472826342613 0.201135258727471 no 2697 0.198418801850158 3705 3104428
SGTC_1434 4073-0095 163 µM -0.849072805797856 0.20064905038168 no 2698 0.197920390653876 3856 24133745
SGTC_110 0850-0284 111.64 µM -0.849485216033333 0.200537140362283 no 2699 0.19780567659164 3698 3906265
SGTC_2263 7948595 193.29 µM -0.849928852637579 0.20041679873425 no 2700 0.197682321612165 3881 2971371
SGTC_3121 9125696 49.47 µM -0.850749050873153 0.200194424618486 no 2701 0.197454384594077 3972 1235365
SGTC_273 hydroxyurea 18.1 mM -0.85491812319481 0.199066390043805 no 2702 0.196298238371969 3972 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3208 9114115 49.47 µM -0.854927181626958 0.199063943261873 no 2703 0.196295730809511 3941 650895
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.856466512479969 0.198648416316475 no 2704 0.195869894090845 3892 688751
SGTC_2511 berberine 10.47 µM -0.858934710663475 0.197983243730405 no 2705 0.195188268913648 3909 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_297 0986-0032 24 µM -0.859323143744878 0.197878684735644 no 2706 0.195081129478891 3876 2847425
SGTC_493 zm226600 134 µM -0.860787646907237 0.197484767674485 no 2707 0.194677504923464 3939 5240098 A potassium channel opener. YCR052W RSC6
SGTC_212 3807-4682 38.772 µM -0.861187883725298 0.19737719589263 no 2708 0.194567286075513 3994 3125501 YBL034C STU1
SGTC_269 exalamide 29 µM -0.861589061098095 0.197269406887618 no 2709 0.194456846331349 3840 3316 A derivative of salicylamide.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.866034572215896 0.196077364583334 no 2710 0.193235601514816 3922 6857784
SGTC_1903 st060211 78.3 µM -0.868448813021696 0.195431832175629 no 2711 0.192574341267182 3972 688960
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.868503048820973 0.195417345163426 no 2712 0.192559501991335 3980 1273210
SGTC_1657 st012939 43.4 µM -0.868879975959948 0.195316681565535 no 2713 0.192456391525544 3945 24207257
SGTC_2853 9015042 58.44 µM -0.870276206880181 0.194944073389261 no 2714 0.192074739180111 3857 6457456
SGTC_1674 st016616 23.6 µM -0.8718949380601 0.194512628646365 no 2715 0.191632847713066 3899 625830
SGTC_1618 st003135 44.5 µM -0.874653315465603 0.19377877119053 no 2716 0.190881284418033 3841 1270615
SGTC_2806 7952793 58.44 µM -0.87576497277979 0.193483496139457 no 2717 0.190578907839794 4003 2972490
SGTC_2159 5658611 73.75 µM -0.876151190300551 0.19338097448696 no 2718 0.190473923528676 3899 793844
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.876307781716281 0.193339416655386 no 2719 0.190431367889535 3832 17037758
SGTC_1784 st039334 36.3 µM -0.876455422400086 0.193300239252323 no 2720 0.190391250069717 4020 3496984
SGTC_659 k018-0002 107 µM -0.877920991446356 0.192911603888807 no 2721 0.189993298328583 3939 6797879 YHR007C ERG11
SGTC_2044 5102272 200 µM -0.878118408792895 0.192859289824534 no 2722 0.189939731919911 3962 592666
SGTC_1766 st045414 44.774 µM -0.881491620159354 0.191966754591685 no 2723 0.189025893817195 3984 253960
SGTC_2110 5483698 200 µM -0.881977495625729 0.191838402938258 no 2724 0.188894488588382 3940 2848765 YHR062C RPP1
SGTC_3052 9092717 49.47 µM -0.882774034051678 0.191628098473593 no 2725 0.188679186234479 3968 25237534
SGTC_1552 6-methylflavone 10.6 µM -0.882919596255219 0.191589681970034 no 2726 0.188639857487448 3856 689013
SGTC_903 1134-0042 114 µM -0.883094037030682 0.191543650102767 no 2727 0.188592732836641 3963 701009
SGTC_3214 9129694 49.47 µM -0.883390803236806 0.191465354264999 no 2728 0.188512579017835 3957 17158655
SGTC_2139 5578692 56.4705 µM -0.883563269334133 0.191419861539784 no 2729 0.188466007166518 3885 650991 YMR113W FOL3
SGTC_2885 9057732 51.95 µM -0.885724168477785 0.190850425901816 no 2730 0.18788309072325 4001 6471414
SGTC_1922 5578187 25 µM -0.885942246492407 0.190793016230581 no 2731 0.187824324685742 3964 1350412
SGTC_2905 7799065 20.05 µM -0.888614254627215 0.190090462935842 no 2732 0.187105213751342 3862 1296806
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.888690042233314 0.190070559252412 no 2733 0.187084842087302 3947 689007
SGTC_1887 st057648 70.8 µM -0.889432582662494 0.189875617686687 no 2734 0.186885320233618 3974 688672
SGTC_224 benfluorex 43.875 µM -0.88989759225476 0.189753599818496 no 2735 0.186760438455477 3955 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_418 lividomycin a 100 µM -0.890389771607985 0.189624505187525 no 2736 0.186628316319598 3926 72394 An antibiotic.
SGTC_332 4112-0506 40.9 µM -0.890770309615743 0.189524730215892 no 2737 0.186526203209392 3933 2790355
SGTC_3237 9133362 49.47 µM -0.891147747803455 0.189425799915536 no 2738 0.186424956087049 3894 43845137
SGTC_2909 7941780 10.49 µM -0.893315033172194 0.188858348286111 no 2739 0.185844244816322 3916 1243215
SGTC_1259 0671-0132 43 µM -0.893725004778602 0.188751124995215 no 2740 0.185734521668213 3885 X1259
SGTC_1975 st070967 30.8 µM -0.894158359212108 0.18863782699823 no 2741 0.185618584134206 3915 261391
SGTC_2666 tannic acid 100 µM -0.896825173836856 0.187941527065802 no 2742 0.184906106393263 3977 16134267 A thiamine antagonist.
SGTC_396 dithiazanine 1.25 µM -0.896922586370972 0.187916122926408 no 2743 0.184880113452873 3961 10578 An antihelmenthic.
SGTC_1386 3228-0095 33.8 µM -0.897042940020237 0.18788473891953 no 2744 0.184848002187531 3999 870181
SGTC_3303 9125618 40.5795 µM -0.899893282834402 0.187142415825485 no 2745 0.184088522574073 4003 22695467
SGTC_2751 anetholtrithion 17.25 µM -0.900731134518006 0.18692455709848 no 2746 0.183865645246175 3999 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1744 st037937 38.9 µM -0.90082825895089 0.186899312895706 no 2747 0.183839820003668 4053 1016152
SGTC_2458 5808907 16.39 µM -0.901469230086168 0.186732767091401 no 2748 0.183669443390409 4105 2731747
SGTC_1139 k015-0024 46.9 µM -0.90162432386099 0.186692482333594 no 2749 0.183628232683299 3984 2766652
SGTC_2332 7982454 138.89 µM -0.901828764361808 0.18663938825528 no 2750 0.183573918626308 3916 2981748
SGTC_3062 9077494 49.47 µM -0.902984704978203 0.186339361400146 no 2751 0.183267006283936 3971 16459633
SGTC_276 colchicine 750 µM -0.903374434260682 0.186238273724421 no 2752 0.183163601921742 4049 2833 A microtubule depolymerizer.
SGTC_729 4092-0585 94.1 µM -0.903826825548251 0.186120975453426 no 2753 0.183043617501642 3989 2169061
SGTC_80 0159-0065 512.242 µM -0.904805516633188 0.185867372276799 no 2754 0.182784214292767 3870 1548079
SGTC_838 0109-0203 71.4 µM -0.904942958416496 0.185831774864433 no 2755 0.182747803573847 3988 759422
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.905202772945066 0.185764494472045 no 2756 0.182678986557499 3938 140250 A respiratory chain inhibitor.
SGTC_2645 abamectin 100 µM -0.905655539135086 0.185647284306387 no 2757 0.182559101150799 3926 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_935 2996-0153 430 µM -0.905942596814624 0.185572995821654 no 2758 0.182483118224584 4001 23738523
SGTC_33 0986-0033 35.816 µM -0.91019122518226 0.184475639017583 no 2759 0.181360835485183 3890 2848082
SGTC_2147 5545932 89.7195 µM -0.911480953769511 0.184143321750938 no 2760 0.181021008255054 4011 797404
SGTC_999 SEC7.066 22.7 µM -0.911578804893285 0.184118124207418 no 2761 0.180995242010499 3970 740511 YDR170C SEC7
SGTC_2987 9018338 71.43 µM -0.911602170684935 0.184112107623599 no 2762 0.180989089649469 4030 5055682
SGTC_1494 4358-1428 177 µM -0.915011398572994 0.18323555911748 no 2763 0.180092823093806 4011 1564571
SGTC_1124 fisetin 1.16336 µM -0.916778382923571 0.182782274534909 no 2764 0.179629391245929 4022 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2461 5755302 26.15 µM -0.919157985225928 0.182172942200934 no 2765 0.17900647175086 4051 2788904
SGTC_1999 st074831 12.5 µM -0.920167882080841 0.18191472740027 no 2766 0.178742517713985 3956 17112523
SGTC_1904 st060225 78 µM -0.920272424543589 0.181888010610619 no 2767 0.178715207733186 3932 66595
SGTC_376 3970-0862 59.1 µM -0.920438801612913 0.181845496478336 no 2768 0.178671749907049 4036 3135186
SGTC_2910 7948405 25.97 µM -0.921041424285424 0.181691561065817 no 2769 0.178514400077986 3899 2971328
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.921649953678086 0.181536199588098 no 2770 0.178355596554003 4058 61125 An anti-inflammatory.
SGTC_1284 0929-0043 16 µM -0.922116029992936 0.181417263546893 no 2771 0.178234028195426 3961 1239883
SGTC_487 nimodipine 119 µM -0.924272373019666 0.180867630685827 no 2772 0.177672261464607 3927 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1921 5740136 50 µM -0.924296929042577 0.180861377588175 no 2773 0.177665870612783 3908 1774243
SGTC_911 3456-4043 236 µM -0.926208273521355 0.180375076793869 no 2774 0.177168876865152 4042 914281
SGTC_336 4111-0029 111 µM -0.92851176966701 0.179790092648544 no 2775 0.176571082728175 4011 3131175
SGTC_941 3237-0776 460 µM -0.928795093328159 0.179718223614486 no 2776 0.176497643899884 4056 760008
SGTC_3079 9117512 49.47 µM -0.92883446745773 0.179708237241101 no 2777 0.176487439469173 4035 7185044
SGTC_1127 asiatic acid 681.4 nM -0.931463212324685 0.179042303292866 no 2778 0.175807002788067 3971 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1254 0550-0035 264 µM -0.933732004799311 0.178468805242233 no 2779 0.175221075729412 4090 15121435
SGTC_2878 9043973 25.97 µM -0.933843187975947 0.178440730492646 no 2780 0.175192393982903 4081 6465167
SGTC_1250 0485-0349 40.2 µM -0.935207434319471 0.178096472591744 no 2781 0.174840703983435 4019 6842794 YDL195W SEC31
SGTC_3211 9128781 49.47 µM -0.940943888549295 0.176653505066463 no 2782 0.173366807418275 4054 17194361
SGTC_1137 ixabepilone 100 µM -0.943250294225738 0.176075433325124 no 2783 0.172776446789986 3986 154225 A novel microtubule stabilizer.
SGTC_1094 duloxetine 25.4 µM -0.944143250300804 0.175851946994662 no 2784 0.172548225197056 4012 60834 A selective serotonin reuptake inhibitor.
SGTC_2380 9035439 200 µM -0.944673095060306 0.175719424027594 no 2785 0.172412898460612 4145 6462575
SGTC_325 2810-4341 181 µM -0.944807987598853 0.175685695272368 no 2786 0.1723784566045 4028 774970
SGTC_2078 5212016 200 µM -0.944822452766602 0.175682078621241 no 2787 0.17237476350122 3879 1899708
SGTC_2877 9040724 71.43 µM -0.946927968649584 0.175156150567759 no 2788 0.171837742457465 4021 6463895
SGTC_2851 9015922 71.43 µM -0.948745405280303 0.174702984526001 no 2789 0.171375057399222 4053 2996893
SGTC_184 1494-0393 24.714 µM -0.94884217557078 0.174678876371187 no 2790 0.171350443859937 4001 3090647
SGTC_852 0418-0143 439 µM -0.949120266573834 0.17460960797094 no 2791 0.171279723946328 4053 5369229
SGTC_196 k015-0023 18.111 µM -0.949775766644946 0.174446401516286 no 2792 0.171113100890814 3962 5211998
SGTC_567 1080-0542 68.4 µM -0.95111746335045 0.174112648033863 no 2793 0.170772375323376 3904 5950415
SGTC_495 decylubiquinone 155 µM -0.951437226767371 0.174033165285099 no 2794 0.170691235119289 4082 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1993 st073995 70.8 µM -0.951656374975576 0.173978705517307 no 2795 0.170635640353286 4019 3098394
SGTC_1540 guanosine 70.6 µM -0.952541988108885 0.173758735229361 no 2796 0.17041109106071 3915 6802 Guanosine is a purine nucleoside
SGTC_3 0833-0587 95.581 µM -0.953895405195893 0.173422912831158 no 2797 0.170068294769704 3948 5382644
SGTC_168 3970-0862 530.542 µM -0.954271745669335 0.173329605204609 no 2798 0.169973053059338 4009 3135186
SGTC_1847 st056231 15 µM -0.954716655536864 0.173219338125132 no 2799 0.169860502381111 4026 5393180
SGTC_1910 st062352 60.4 µM -0.955422108919678 0.173044589171657 no 2800 0.169682138918203 3967 2245730
SGTC_1991 st073000 8.92 µM -0.956533057451407 0.172769622157314 no 2801 0.169401495649879 4116 4301969 YIL048W NEO1
SGTC_1255 0566-0045 221 µM -0.95742647709993 0.17254869711137 no 2802 0.16917601987422 4086 2788469
SGTC_1497 4476-2978 41.3 µM -0.960711224630209 0.171737993453372 no 2803 0.168348692914682 4086 1528379
SGTC_1750 st081859 2.357 µM -0.962581685270316 0.17127743680704 no 2804 0.167878746106232 4004 5291695
SGTC_3145 9085516 49.47 µM -0.963224990138616 0.171119220876625 no 2805 0.167717313332747 4107 25236195
SGTC_879 0831-1030 162 µM -0.964830348727398 0.170724802979539 no 2806 0.167314896191302 4078 1549252
SGTC_2095 5432005 200 µM -0.967711223308095 0.170018465977669 no 2807 0.166594305681199 4055 783734
SGTC_2818 7996756 12.99 µM -0.96778045969524 0.170001513582028 no 2808 0.166577012331622 4059 2241621
SGTC_1647 st011722 22.4 µM -0.969923628064651 0.169477298853977 no 2809 0.166042280766718 4025 2854783
SGTC_773 4358-1457 44.6 µM -0.96995586260946 0.1694694222744 no 2810 0.166034246557239 4015 1186886
SGTC_1772 st048439 82.2 µM -0.970356726662367 0.169371489915742 no 2811 0.16593435529687 4109 2927068 YDL195W SEC31
SGTC_182 3448-4371 550.524 µM -0.970808145010773 0.169261250473898 no 2812 0.165821912924448 3948 3491403
SGTC_3063 1327-0034 4 µM -0.972208412989463 0.168919588597167 no 2813 0.165473438024411 3958 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_449 xestospongin c 11.1929 µM -0.972370162720099 0.168880150632586 no 2814 0.165433215043161 4068 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_98 0074-0023 107.663 µM -0.973308427534507 0.168651498756447 no 2815 0.165200017587225 4080 3563821
SGTC_657 3534-0529 86.7 µM -0.973822858791213 0.168526218143593 no 2816 0.165072250577347 4121 1049549
SGTC_2661 dactinomycin 12.96 µM -0.973907185489676 0.168505687580315 no 2817 0.165051312833651 4033 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_565 1418-0001 44.5 µM -0.97395095930992 0.168495030840108 no 2818 0.165040444770795 4141 2862145
SGTC_2282 7944268 200 µM -0.975317195246525 0.168162638423801 no 2819 0.164701471784888 4094 2970414
SGTC_1943 st076331 65.2 µM -0.977309260796477 0.167678744082278 no 2820 0.164208034857667 4080 24208415
SGTC_2745 rifampicin 24.3 µM -0.978276239203101 0.167444178153514 no 2821 0.163968859188581 4073 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1436 4092-1007 8.32 µM -0.978761653501422 0.167326507951394 no 2822 0.163848880449611 4058 2881121
SGTC_2764 methyldopa 94.69 µM -0.979426336792105 0.167165467284163 no 2823 0.163684684650459 4063 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2125 5246583 200 µM -0.980391949746764 0.166931694915172 no 2824 0.163446340989308 4060 835267
SGTC_149 3970-0822 46.1 µM -0.983123027226316 0.166271650387204 no 2825 0.162773446147919 4077 3114250 YBL034C STU1
SGTC_1615 st002656 86.5 µM -0.983880401497081 0.166088907736984 no 2826 0.162587160507044 4067 1584458
SGTC_1111 tnp00062 510.699 nM -0.984339374619791 0.165978227819635 no 2827 0.162474337872161 4117 676306
SGTC_1156 4092-0367 4.88 µM -0.985324374775875 0.165740859091738 no 2828 0.162232381760122 4081 1357585
SGTC_3264 9137442 49.47 µM -0.9855799398999 0.165679308005703 no 2829 0.162169642917509 4084 17015726
SGTC_1378 2093-0007 380 nM -0.98684500559609 0.165374843412644 no 2830 0.161859313839059 4152 3618014
SGTC_1749 st037932 54.2 µM -0.987430770261328 0.165233989554444 no 2831 0.161715752990758 4131 594497
SGTC_467 ro 31-8220 72.8 µM -0.994170602718284 0.163618907661942 no 2832 0.160069908701087 4020 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1329 1447-1697 50.6 µM -0.994940995120104 0.163434951682033 no 2833 0.159882481436914 4084 2840515
SGTC_2704 st078022 71.1 µM -0.995054031954135 0.163407971805471 no 2834 0.159854993007397 4146 54697681
SGTC_1788 fluconazole 20 µM -0.995298000919847 0.163349750624751 no 2835 0.159795674886319 4132 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2911 7942208 15.64 µM -0.99616351967644 0.163143310434772 no 2836 0.159585350583468 4121 1243384
SGTC_1656 st012921 11 µM -0.997691243091048 0.162779337705606 no 2837 0.159214550408231 3994 6732821
SGTC_173 1273-0061 2.693 µM -1.00033151158529 0.162151552498019 no 2838 0.15857505112926 4069 2847414 YPL266W DIM1
SGTC_2117 5521686 200 µM -1.00040315430811 0.162134539774971 no 2839 0.158557722055593 4041 803312
SGTC_619 1652-1634 108 µM -1.0007774501777 0.162045676068494 no 2840 0.158467206875709 4063 5400454
SGTC_3127 9126946 49.47 µM -1.00401719586713 0.161277835522809 no 2841 0.157685162576863 4096 27243249
SGTC_1897 st060201 15 µM -1.00557638265096 0.160909145571319 no 2842 0.157309694727817 4145 611878
SGTC_307 1501-1223 22.3 µM -1.00567195584738 0.160886563958708 no 2843 0.157286698874927 4124 2830329
SGTC_3137 9097352 49.47 µM -1.00567555563557 0.160885713457087 no 2844 0.157285832773604 4119 44120435
SGTC_1853 st056710 91.2 µM -1.00655775290087 0.160677370191014 no 2845 0.157073672542987 4163 269167
SGTC_1427 4048-4900 550 nM -1.00691722309796 0.160592526806879 no 2846 0.156987277305319 4085 24132586
SGTC_645 0845-0943 5.41 µM -1.00747772357033 0.160460293967413 no 2847 0.156852628738276 4097 1885106
SGTC_1817 st052116 64.4 µM -1.00821283500288 0.160286974907926 no 2848 0.156676148746253 4123 4361398
SGTC_1524 corynanthine 62.1 µM -1.01018229610337 0.15982323339237 no 2849 0.156203979809746 4239 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_590 k048-0076 22.4 µM -1.01019029026941 0.159821352826834 no 2850 0.156202065158816 4127 6832814
SGTC_2747 doxorubicin 7.63 µM -1.0115163352666 0.159509611378664 no 2851 0.155884683391322 4070 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1515 3460-0031 42.1 µM -1.01198442158032 0.159399663540738 no 2852 0.155772751031039 4040 2876596
SGTC_1755 st041960 45.185 µM -1.0125120443291 0.159275790811703 no 2853 0.155646645417074 4160 2257073
SGTC_1795 st049545 62.3 µM -1.0125220622514 0.15927343946214 no 2854 0.155644251713466 4042 5291882
SGTC_1914 st062367 72.6 µM -1.0145596948143 0.158795650523734 no 2855 0.155157880172296 4096 978205
SGTC_2271 7849410 118.62 µM -1.01690174485746 0.158247642784112 no 2856 0.15460008660767 4025 972430
SGTC_2476 5806916 10.51 µM -1.01739877542901 0.158131504234298 no 2857 0.154481882166493 3969 2870194
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.01782084666698 0.158032924977827 no 2858 0.154381551568474 3993 6708630 An antioxidant.
SGTC_1862 st057513 3.81 µM -1.01848747431167 0.157877309151392 no 2859 0.154223175219466 4088 5393163
SGTC_3278 9139605 49.47 µM -1.01865416208664 0.157838413721795 no 2860 0.154183590599326 4132 7958859
SGTC_1420 4'-methoxyflavone 42 µM -1.0224510505079 0.15695414070416 no 2861 0.153283734505848 4099 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2918 7977171 22.06 µM -1.02411021796515 0.156568755572102 no 2862 0.152891609348509 4087 2236483
SGTC_2017 5132927 60.65 µM -1.02652077675498 0.156009951115023 no 2863 0.15232308769162 4121 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2925 9010536 32.5 µM -1.0287018093065 0.155505488432109 no 2864 0.151809909732317 4057 2994177
SGTC_3221 9128209 49.47 µM -1.02894219476485 0.155449954308101 no 2865 0.15175341949556 4154 16460723
SGTC_220 paclitaxel 373.376 µM -1.02922927765528 0.155383649237114 no 2866 0.151685973734728 4091 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2942 9052777 62.25 µM -1.02926484699012 0.155375435392729 no 2867 0.151677618647559 4180 6469503
SGTC_2961 9083290 32.55 µM -1.03007058319667 0.155189447615278 no 2868 0.151488436542795 4054 17741490
SGTC_1369 1866-0067 208 µM -1.03115902646114 0.154938436132461 no 2869 0.15123312570143 4142 3531355
SGTC_1908 st060353 56.5 µM -1.03160381245634 0.154835938972549 no 2870 0.151128876843246 4192 4227716
SGTC_3058 9093861 49.47 µM -1.0335462313502 0.1543888500452 no 2871 0.150674173498311 4133 17217477
SGTC_1937 st074714 47.2 µM -1.0352061261995 0.154007467032305 no 2872 0.150286329198178 4083 17250970
SGTC_639 0833-0042 114 µM -1.03524141967255 0.153999364659176 no 2873 0.150278089898218 4128 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2989 9073649 71.4286 µM -1.0357069861153 0.153892510304312 no 2874 0.150169431078847 4045 21367202
SGTC_2098 5376439 882.5 nM -1.03615249815648 0.153790304682899 no 2875 0.150065501813475 4170 2844116
SGTC_2994 9053520 71.4286 µM -1.03762212037358 0.153453474959863 no 2876 0.149723007697106 4177 4647384
SGTC_1467 k284-1082 293 µM -1.03981234822039 0.152952393626396 no 2877 0.149213545530898 4093 3334705
SGTC_549 1661-1316 519 µM -1.0425488988367 0.152327850429119 no 2878 0.148578633500327 4166 2857282
SGTC_2526 patulin 37.61 µM -1.04300983194536 0.152222821804893 no 2879 0.148471869585094 4163 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_428 3448-4153 16.5 µM -1.04365490277609 0.152075916142669 no 2880 0.148322540815907 4107 3834874
SGTC_1637 st007924 17.4 µM -1.04547459266818 0.151662015357131 no 2881 0.147901838666434 4061 683336
SGTC_528 3492-0019 172 µM -1.04693788000196 0.151329724370572 no 2882 0.14756411482887 4128 2869262
SGTC_2724 maprotiline 69.64 µM -1.04704011260835 0.151306526962569 no 2883 0.147540539066655 4057 4011 A tricyclic antidepressant.
SGTC_2786 7743617 45.45 µM -1.04709581991825 0.151293887517442 no 2884 0.147527693520107 4104 583674
SGTC_2621 lithochol-11-enic acid 100 µM -1.04770729360572 0.151155196264355 no 2885 0.147386743074013 4077 6708711
SGTC_3194 9111903 49.47 µM -1.04845715190086 0.150985232841366 no 2886 0.147214016897618 4186 17087251
SGTC_594 1487-1584 10.8 µM -1.04920991504142 0.150814738980588 no 2887 0.147040758137086 4100 5013332
SGTC_1758 st042942 75.2445 µM -1.049580148798 0.150730931512154 no 2888 0.146955593943574 4090 669317
SGTC_1352 1496-0991 99 µM -1.05024549541302 0.150580399167692 no 2889 0.146802628638395 4118 3000039
SGTC_1273 0849-0096 14.1 µM -1.05164795525026 0.150263425605282 no 2890 0.146480548637055 4163 5286025
SGTC_1073 triclabendazole 3.09 µM -1.05318508410068 0.149916526279259 no 2891 0.146128086647855 4200 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1987 st072290 61.9 µM -1.05639565156458 0.149193689223523 no 2892 0.145393745914233 4160 54697379
SGTC_420 mitomycin C 81.9 mM -1.05717079618131 0.149019520157476 no 2893 0.14521682272261 4135 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1189 1431-2119 7.28 µM -1.05999004795399 0.148387201618657 no 2894 0.144574563464097 4147 3107275
SGTC_1271 0832-2808 169 µM -1.06170560849712 0.148003305017286 no 2895 0.144184676220497 4186 3663794
SGTC_2536 dehydroabietamide 32.04 µM -1.06181755806583 0.147978276821751 no 2896 0.144159258638796 4254 3983547
SGTC_439 amiodarone 34.4 µM -1.06263067205831 0.14779657662849 no 2897 0.143974735891603 4018 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1846 st056244 14.8 µM -1.06367624859195 0.14756314950553 no 2898 0.143737693841564 4187 5393182
SGTC_281 1672-3440 14.9 µM -1.06612236685944 0.14701801375416 no 2899 0.1431841649776 4203 6833000
SGTC_2797 7859098 81.82 µM -1.07129498835489 0.145869708674208 no 2900 0.142018406270765 4156 972681
SGTC_1461 k072-0203 53.8 µM -1.07181644628979 0.145754282082289 no 2901 0.14190124231909 4070 5418714
SGTC_2123 5259487 200 µM -1.07187370234996 0.145741611988949 no 2902 0.141888381710699 4180 2173474
SGTC_3274 9138298 49.47 µM -1.07507760852727 0.145033804944307 no 2903 0.141169991733508 4135 17015756
SGTC_2100 5377183 190 µM -1.07856732369044 0.144265493799204 no 2904 0.140390327285142 4187 2844202
SGTC_746 1095-0025 46.6 µM -1.0792198185757 0.144122142651102 no 2905 0.140244873399198 4183 6749286
SGTC_1929 genistein trimethyl ether 50.5 µM -1.07978840365953 0.143997304570284 no 2906 0.140118208137545 4168 136420
SGTC_2061 5245884 80.95 µM -1.08010383994571 0.143928079096349 no 2907 0.140047971057978 4145 573863
SGTC_108 0509-0257 621.132 µM -1.08126217303155 0.143674064545514 no 2908 0.139790254375504 4133 536624
SGTC_1428 4049-0204 61.7 µM -1.08191251279683 0.143531582157289 no 2909 0.13964570215617 4233 X1428
SGTC_2291 7917025 104.35 µM -1.08207753436363 0.143495442899286 no 2910 0.139609038681286 4091 2964612
SGTC_994 3910-0338 138 µM -1.08314856111399 0.143261040375378 no 2911 0.139371243667348 4244 3479481
SGTC_427 1354-0053 47.3 µM -1.0845788459319 0.142948414903786 no 2912 0.139054114203258 4250 6813657
SGTC_3067 9117431 49.47 µM -1.08609057383386 0.142618489451317 no 2913 0.138719461144718 4205 17150885
SGTC_2808 7946468 45.46 µM -1.08735021018817 0.142343975011347 no 2914 0.138441033220996 4173 2970879
SGTC_1649 st011737 51.3 µM -1.08846428417523 0.142101481282113 no 2915 0.138195097742005 4179 1761035
SGTC_470 aa-861 153 µM -1.08869362459694 0.142051596868061 no 2916 0.138144507088059 4154 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2102 5377816 72.7585 µM -1.08974590457329 0.141822864776969 no 2917 0.137912544494798 4234 1379702
SGTC_95 0471-0001 561.058 µM -1.09272889040405 0.141175815099777 no 2918 0.137256425581227 4180 4015405
SGTC_1957 st077035 62.4 µM -1.09458657640174 0.14077387099792 no 2919 0.136848899562207 4196 705593
SGTC_1323 1348-1351 11.2 µM -1.09516523909261 0.140648825581932 no 2920 0.136722125739039 4138 6989654
SGTC_599 1935-0052 86.5 µM -1.09520655254997 0.140639900884292 no 2921 0.136713077830008 4178 9557311
SGTC_2333 9017922 200 µM -1.09548048758214 0.140580734070874 no 2922 0.136653094677975 4227 3163164
SGTC_1327 1436-0082 2.18 µM -1.09804649767699 0.140027325838048 no 2923 0.136092092985548 4198 15992205
SGTC_784 4579-0127 173 µM -1.100384071123 0.139524474373302 no 2924 0.1355824078902 4236 1948547
SGTC_3346 9158254 43.5805 µM -1.10229752608852 0.139113773140101 no 2925 0.135166172271346 4204 17639500
SGTC_135 0933-0004 26.348 µM -1.10253534375735 0.139062785845665 no 2926 0.135114500855065 4170 21230617 YGL099W LSG1
SGTC_3341 9147222 25.867 µM -1.10323313423101 0.138913255382765 no 2927 0.134962967839525 4196 1939759
SGTC_725 1497-0963 19 µM -1.10476757976582 0.138584822163878 no 2928 0.13463015593677 4315 3549977
SGTC_2683 piperine 63.03 µM -1.1069717344081 0.138113970653668 no 2929 0.134153074599433 4173 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2749 bexarotene 57.39 µM -1.10706204219485 0.13809470239571 no 2930 0.134133552600891 4230 82146 An retinoic acid receptor inhibitor.
SGTC_333 3486-0131 40.1 µM -1.10907071459644 0.137666601664852 no 2931 0.133699838639475 4235 6744690
SGTC_2627 acetyl isogambogic acid 100 µM -1.10978583920522 0.137514408732294 no 2932 0.133545661418481 4225 6857789 A caspase activator and apoptosis inducer.
SGTC_2718 lomofungin 53.02 µM -1.11053663052525 0.137354748844783 no 2933 0.13338392625046 4190 5351222 A RNA synthesis inhibitor.
SGTC_972 1319-0219 195 µM -1.11120851546366 0.137211976200797 no 2934 0.133239303354417 4184 23903702
SGTC_1070 indatraline 8.81 µM -1.11430932617446 0.136554381022722 no 2935 0.132573253695832 4243 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_9 0092-0002 10.449 µM -1.11735799011011 0.13590994917066 no 2936 0.131920644871987 4195 759368
SGTC_1645 Cervolide 78 µM -1.11852163068608 0.135664526786647 no 2937 0.131672136740289 4209 23173 A fragrance.
SGTC_1564 D-Arginine 115 µM -1.12065717749418 0.135214910759171 no 2938 0.131216908323839 4232 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_161 4065-0411 162.148 µM -1.12197759008401 0.134937423994223 no 2939 0.130935984179843 4204 1906281 YLR208W SEC13
SGTC_2340 7987427 183.45 µM -1.12544948774315 0.134209664077232 no 2940 0.130199305259779 4241 2239331
SGTC_2083 5306046 65.942 µM -1.12628160862996 0.134035640771316 no 2941 0.130023169935925 4222 539837
SGTC_505 gw-5074 63.9 µM -1.12862497404153 0.133546400850033 no 2942 0.129528035431408 4240 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2746 daunorubicin 9.88 µM -1.12868472196337 0.133533942956462 no 2943 0.129515428270317 4168 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.13138582012614 0.132971578224299 no 2944 0.128946368547093 4166 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_367 0335-0881 7.1 µM -1.1323871988141 0.132763507495212 no 2945 0.128735842168171 4181 23828853
SGTC_2799 7812892 81.82 µM -1.13355480124653 0.132521181372472 no 2946 0.12849067076721 4255 20205235
SGTC_475 α-linolenic acid 10 µM -1.13438652002073 0.132348751063266 no 2947 0.128316225486069 4234 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1986 st071812 45 µM -1.13511331594147 0.132198199809269 no 2948 0.128163921488306 4168 11838594
SGTC_2362 9071156 126 µM -1.13526245528204 0.132167321127832 no 2949 0.128132684068161 4238 653133
SGTC_1782 st039423 80.636 µM -1.1386553887209 0.13146617155641 no 2950 0.127423458263292 4269 2068169
SGTC_3316 9136639 10.545 µM -1.13966704858659 0.131257609945383 no 2951 0.127212520098915 4235 4903665
SGTC_1173 0443-0020 122 µM -1.14030556962059 0.131126091513173 no 2952 0.127079509116791 4221 5331295
SGTC_3244 9134489 49.47 µM -1.14817070241426 0.129513547054205 no 2953 0.12544905067403 4247 16584271
SGTC_1293 1000-1278 195 µM -1.15307204151314 0.128515629297128 no 2954 0.124440408067009 4279 678847
SGTC_851 0394-0702 453 µM -1.15373578405718 0.128380902025617 no 2955 0.12430425421389 4244 762646
SGTC_1684 st024538 14.6195 µM -1.15394612109942 0.128338228023459 no 2956 0.124261129415399 4199 6732859
SGTC_1480 1070-0044 41.2 µM -1.15401733668744 0.128323781758311 no 2957 0.124246530659994 4263 3124987
SGTC_296 1222-0039 74.9 µM -1.15744443509782 0.127629920214034 no 2958 0.12354541425531 4255 5984176
SGTC_1390 3413-2614 145 µM -1.16324540028392 0.126461390404503 no 2959 0.122364975608965 4266 3421432
SGTC_1447 4239-0816 81.9 µM -1.16335283743942 0.126439819101786 no 2960 0.122343188137011 4248 1341554
SGTC_644 1498-1197 63.3 µM -1.16427300131452 0.12625517299287 no 2961 0.122156697132835 4271 6741615
SGTC_2272 7805186 180 µM -1.16760657163302 0.12558781096005 no 2962 0.121482749092329 4263 2956062 YPR165W RHO1
SGTC_1008 4106-0037 6 µM -1.16812027559818 0.125485189602032 no 2963 0.121379126421223 4274 2905394
SGTC_2950 9072895 21.46 µM -1.1692812930472 0.125253471689109 no 2964 0.121145158799615 4231 17332245
SGTC_1870 st057514 26.5 µM -1.16978176008522 0.12515367979594 no 2965 0.121044402853931 4248 5393161
SGTC_2010 4012422 159 µM -1.17044802377448 0.12502091463712 no 2966 0.120910359596373 4214 952393
SGTC_2168 5727979 200 µM -1.1719935789128 0.124713313547026 no 2967 0.120599817068219 4168 695210
SGTC_3022 9087993 49.47 µM -1.17365760162126 0.124382726412778 no 2968 0.120266099561869 4329 17173644
SGTC_3066 9117245 49.47 µM -1.1737365415275 0.124367058863106 no 2969 0.120250284449822 4312 17176980
SGTC_627 1391-0720 175 µM -1.17617306098905 0.123884150739991 no 2970 0.119762863551134 4231 997839
SGTC_1230 0170-0365 3.77 µM -1.17650574221338 0.123818316664809 no 2971 0.119696419582079 4317 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1092 toremifene 6.32 µM -1.1789916333782 0.123327160426642 no 2972 0.119200753701169 4255 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3266 9136860 49.47 µM -1.18175011814706 0.122783745466362 no 2973 0.118652432800635 4087 4871271 YPR165W RHO1
SGTC_2854 9024559 71.43 µM -1.18208753339085 0.122717390909475 no 2974 0.118585485231514 4294 3163529
SGTC_103 0844-0104 51.839 µM -1.18358171505159 0.122423854218462 no 2975 0.118289341006708 4129 5375804
SGTC_2700 st077718 96.8 µM -1.18412678931747 0.122316895424592 no 2976 0.118181438502606 4275 904970
SGTC_502 l-744,832 89.3 µM -1.18537404160125 0.122072396505422 no 2977 0.117934795253422 4281 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2019 4016004 108 µM -1.19360528628823 0.120467430586031 no 2978 0.116316202584566 4318 45595336
SGTC_2656 pseudo-anisatin 100 µM -1.19517609755437 0.120162842950858 no 2979 0.116009117627295 4326 6708809 A neurotoxin.
SGTC_2790 5423970 71.43 µM -1.19561523196794 0.12007778987997 no 2980 0.115923372297629 4326 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2077 5212015 200 µM -1.19908145026666 0.119407929723862 no 2981 0.115248138086538 4162 780900
SGTC_1466 k213-0079 57.5 µM -1.20170268813877 0.11890311926804 no 2982 0.114739369643091 4230 3657981
SGTC_1460 k062-0059 9.15 µM -1.20218710254084 0.118809993688418 no 2983 0.114645522581919 4168 1373085
SGTC_2539 epi(13)torulosol 80 µM -1.20439336971499 0.118386504587035 no 2984 0.114218786747756 4294 6708597
SGTC_417 st075190 100 µM -1.20663342996712 0.117957621790653 no 2985 0.113786673230253 4289 222757
SGTC_2103 5378138 10 µM -1.20667013796675 0.117950602828459 no 2986 0.113779601876728 4367 244142
SGTC_2675 theaflavin digallate 100 µM -1.20934880073592 0.117439211090455 no 2987 0.113264434862615 4235 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1179 1021-1431 9.29 µM -1.20994741285872 0.117325143161907 no 2988 0.113149536142037 4313 2840958
SGTC_3147 9097027 49.47 µM -1.21025634220356 0.117266306149234 no 2989 0.11309027221636 4281 25236841
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.21034520685814 0.117249385338805 no 2990 0.113073228834602 4338 6708784 An antioxidant flavonoid
SGTC_1395 3486-0190 4.35 µM -1.2105876384017 0.11720323249378 no 2991 0.113026742129325 4275 6748079
SGTC_797 k781-0471 270 µM -1.21348320230721 0.116652984847942 no 2992 0.112472566388801 4268 23738129
SGTC_450 aminopyrene 156 nM -1.21816221792448 0.1157677017505 no 2993 0.111581167066348 4260 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3018 9082602 49.47 µM -1.21825877209978 0.115749483809827 no 2994 0.11156282591368 4230 17332089
SGTC_2651 TUB2.036 5 µM -1.21905364785024 0.115599583215547 no 2995 0.111411915584455 4228 15992207 YFL037W TUB2
SGTC_3206 9114350 49.47 µM -1.21950722002541 0.115514108731427 no 2996 0.111325868598878 4164 17087243
SGTC_109 0132-0036 33.701 µM -1.22216054598441 0.115014996077231 no 2997 0.110823460298432 4123 67274 A color developer.
SGTC_2869 9037858 32.47 µM -1.22251938850793 0.114947612730459 no 2998 0.110755638231647 4260 27187042
SGTC_308 4092-1169 104 µM -1.22396659604105 0.114676141489098 no 2999 0.110482414513385 4251 2268590 YDL196W YDL196W
SGTC_1833 st055984 71 µM -1.22487578322032 0.114505827124445 no 3000 0.110311012997553 4309 676288
SGTC_705 1124-0212 310 µM -1.22613343555116 0.114270533087881 no 3001 0.110074232685344 4302 9554485
SGTC_2755 lomerizine 42.69 µM -1.22697162171832 0.114113908250607 no 3002 0.10991662859026 4260 3949 A calcium channel blocker.
SGTC_1134 3477-0009 42.5 µM -1.22814014430624 0.113895811488208 no 3003 0.109697181697423 4372 3973534
SGTC_410 α-linolenic acid 100 µM -1.23178368846769 0.113217676284166 no 3004 0.109014949032746 4341 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2912 7964298 10.93 µM -1.23485276825675 0.112648699299712 no 3005 0.108442652198499 4320 2975850
SGTC_1765 st044815 90.4 µM -1.23620384944543 0.112398870658228 no 3006 0.108191400093546 4335 645695
SGTC_2520 obtusaquinone 4.71 µM -1.24022871975057 0.111656978094425 no 3007 0.107445404263851 4361 5967872
SGTC_1578 josamycin 24.2 µM -1.24254095663818 0.111232357973635 no 3008 0.107018519495418 4321 5282165 A P450 substrate.
SGTC_1241 0364-0022 50.8 µM -1.24550974370652 0.110688865522965 no 3009 0.106472218069334 4314 4563895
SGTC_2299 7976368 114.88 µM -1.2473432897902 0.110354152433263 no 3010 0.106135825400459 4340 2979718
SGTC_1701 st028638 40.4 µM -1.2535125581807 0.109233285714508 no 3011 0.105009615843778 4330 3490878
SGTC_2524 avocatin b 10.57 µM -1.2538369808503 0.109174570025483 no 3012 0.104950632301717 4322 6710748
SGTC_2246 7293507 91.5585 µM -1.25479590248245 0.109001152032306 no 3013 0.104776430227041 4391 887656
SGTC_3328 9140624 29.0385 µM -1.25549911677921 0.10887410381641 no 3014 0.104648814256974 4339 4904392
SGTC_386 1509-0011 3.07 µM -1.25589102428237 0.10880334494692 no 3015 0.104577741630234 4338 3107280
SGTC_1504 k297-0033 30 µM -1.25621546056197 0.108744793023671 no 3016 0.104518931404465 4207 4388117
SGTC_402 epigallocatechin gallate 10 µM -1.25778063642359 0.108462639682272 no 3017 0.104235550215907 4286 65064 An antioxidant.
SGTC_2131 toluylene red 5.2905 µM -1.2596120084645 0.108133168470312 no 3018 0.103904680713058 4298 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3149 9097855 49.47 µM -1.26062963959621 0.10795040422684 no 3019 0.103721157340188 4331 25236625 YMR079W SEC14
SGTC_422 cantharidin 155 µM -1.26283033418436 0.107555925388713 no 3020 0.103325080347733 4249 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1333 1482-0047 286 µM -1.26638827218278 0.106920357154357 no 3021 0.102687053808435 4350 3811116
SGTC_2483 5729050 27.16 µM -1.26936245114881 0.106391150752928 no 3022 0.102155910947465 4362 2865180
SGTC_3019 9081971 49.47 µM -1.27068496047968 0.106156440383071 no 3023 0.101920374039243 4357 16451803
SGTC_180 1486-1293 102.781 µM -1.27220091138301 0.105887859650623 no 3024 0.101650871951734 4286 4140536
SGTC_3061 glucosamine 200 µM -1.27520090663075 0.105357799380134 no 3025 0.101119070248847 4288 91431 and experimental redox chemotherapeutic
SGTC_3053 9095903 49.47 µM -1.27621773732849 0.105178574868792 no 3026 0.100939280111568 4467 17174018
SGTC_2824 7998404 51.95 µM -1.2821683629409 0.104134151988775 no 3027 0.0998917958636993 4303 837851
SGTC_48 0382-0018 55 µM -1.28397324237396 0.103818860023469 no 3028 0.0995756589836077 4394 762596
SGTC_805 3852-0218 479 µM -1.2869621088221 0.10329826276135 no 3029 0.0990537477007077 4316 6615355
SGTC_453 enantio-paf c16 10 µM -1.28904894802483 0.102935904883928 no 3030 0.098690535106154 4063 13871343 A lipid and platelet activating factor
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.29163598709476 0.102487975638367 no 3031 0.0982416176215461 4349 15053
SGTC_105 0111-0055 734.78 µM -1.29347387549667 0.102170619176215 no 3032 0.097923606924756 4373 5179370
SGTC_227 fluconazole 33.516 µM -1.29730543127479 0.101511307123195 no 3033 0.0972630581855748 4365 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1554 st069299 38.7 µM -1.29830450149136 0.101339903315132 no 3034 0.0970913600871417 4324 24207999
SGTC_2457 5731572 11.68 µM -1.30513023217937 0.100174496846765 no 3035 0.0959242529447002 4420 2865357
SGTC_827 3253-0474 693 µM -1.30557142154637 0.100099507415289 no 3036 0.0958491721145288 4387 5402065
SGTC_2229 7354935 190 µM -1.30840344078728 0.0996191218109435 no 3037 0.0953682531034703 4317 318112
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.31149683780043 0.0990963270188536 no 3038 0.0948449806920548 4484 16725076
SGTC_1318 1280-3875 124 µM -1.31357040077101 0.0987470128443035 no 3039 0.0944954074878444 4380 373245
SGTC_2572 astragaloside iv 100 µM -1.31422144924529 0.0986375227707217 no 3040 0.094385846174755 4389 45006101 An anti-inflammatory agent.
SGTC_1113 artemisinin 1.17947 µM -1.31550657710178 0.0984216572804823 no 3041 0.0941698541851191 4418 2240 An anti-malaria and mitochondrial poison.
SGTC_1268 0828-0275 2.46 µM -1.31662555619333 0.0982339820361638 no 3042 0.0939820840400317 4431 745337
SGTC_478 N-arachidonylglycine 10 µM -1.31767120112035 0.0980588434560076 no 3043 0.0938068695810286 4375 5283389
SGTC_47 0149-0135 24.25 µM -1.31904488178978 0.0978291089263777 no 3044 0.093577054130363 4388 5239155
SGTC_2491 paeonol 100 µM -1.32023307148273 0.0976307143529355 no 3045 0.0933786067145166 4327 11092 Increases levels of cortical cytochrome oxidase.
SGTC_29 0299-0004 12.984 µM -1.32066073681014 0.0975593784104854 no 3046 0.0933072556400068 4282 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2208 7283366 200 µM -1.32084948007549 0.0975279075914715 no 3047 0.093275778796558 4363 898663
SGTC_264 promethazine 12.5 mM -1.3209069940874 0.0975183192563471 no 3048 0.0932661887052323 4253 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2409 alverine citrate 63.97 µM -1.3212547779559 0.0974603538841608 no 3049 0.0932082135050436 4444 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2549 cedrol 20.94 µM -1.32423685463219 0.0969643662293586 no 3050 0.0927121972465838 4324 6708665 A sedative which affects the nervous system.
SGTC_2155 5570423 76 µM -1.3269103575243 0.0965212790037448 no 3051 0.0922691688645104 4341 797402
SGTC_2598 perillyl alcohol 100 µM -1.33132848998665 0.0957923126704707 no 3052 0.0915404738850644 4416 10819 An apoptosis inducer.
SGTC_1808 st050063 61.5 µM -1.3314723745019 0.095768640837745 no 3053 0.0915168145226042 4361 4011993
SGTC_1561 5-methoxyflavone 52.9 µM -1.33304880186752 0.0955095693342943 no 3054 0.0912578946052822 4349 94525
SGTC_2601 securinine 100 µM -1.33312453180893 0.0954971368041824 no 3055 0.091245470046687 4365 442872 A GABA receptor antagonist.
SGTC_562 3772-2733 112 µM -1.33315280158749 0.0954924960802527 no 3056 0.0912408323146888 4377 2876874 YIL048W NEO1
SGTC_1468 k284-1086 134 µM -1.33809332097084 0.0946840149854953 no 3057 0.0904330088695882 4393 15996457
SGTC_585 0kpi-0023 191 µM -1.3390202937626 0.0945328861845246 no 3058 0.0902820332225133 4329 64601
SGTC_2041 5107442 45.335 µM -1.34020976357865 0.0943392218445433 no 3059 0.0900885791263477 4426 793005
SGTC_974 1326-0144 138 µM -1.34022277570643 0.0943371048852144 no 3060 0.0900864645521414 4418 5411856
SGTC_739 1486-1183 203 µM -1.34277650308047 0.0939223136192417 no 3061 0.0896721769892654 4397 4346692
SGTC_608 k048-0125 159 µM -1.350527276324 0.0926716317649123 no 3062 0.0884234552010387 4443 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2353 9059630 146.67 µM -1.35221206421338 0.0924014079669953 no 3063 0.0881537427150706 4438 4779114
SGTC_2648 atorvastatin 78.68 µM -1.35280280835243 0.092306796476644 no 3064 0.0880593176751778 4396 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_844 0330-0132 15.3 µM -1.35349608779147 0.0921958547612069 no 3065 0.0879485995102346 4460 2828079
SGTC_1973 st070275 50.2 µM -1.3536892234821 0.092164965898974 no 3066 0.0879177738356999 4347 17118334
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.35385883278949 0.0921378460116262 no 3067 0.0878907097659556 4431 5106787 A p450 inhibitor.
SGTC_684 1140-0066 328 µM -1.35700249940056 0.0916362546164453 no 3068 0.0873902081765294 4439 6813534
SGTC_1192 1488-0095 21.4 µM -1.35767531134916 0.0915291666655811 no 3069 0.0872833670535896 4431 915875
SGTC_3280 9140961 49.47 µM -1.35780563403646 0.0915084346130847 no 3070 0.0872626833638026 4438 4901226
SGTC_1450 4112-4260 37.6 µM -1.35945879188219 0.0912457482282773 no 3071 0.0870006260062405 4403 1633175
SGTC_1357 1503-1303 39.5 µM -1.36032068870773 0.091109014969644 no 3072 0.0868642321077748 4387 292895
SGTC_558 k064-0027 21.3 µM -1.36114915857109 0.090977727930261 no 3073 0.0867332786224617 4417 5088526
SGTC_2257 7960413 200 µM -1.36214947714398 0.0908193952320601 no 3074 0.0865753582599645 4445 2974689 YIL048W NEO1
SGTC_545 4218-0007 221 µM -1.36440716072202 0.090462795595641 no 3075 0.0862197277271158 4401 2840508
SGTC_1209 2323-2347 50.3 µM -1.36442142428118 0.0904605459853331 no 3076 0.0862174844085773 4406 5412760
SGTC_623 k072-0108 16.9 µM -1.36679476058964 0.0900868079355469 no 3077 0.0858448227568616 4385 5382803
SGTC_1889 st059080 5.18 µM -1.36695910456263 0.090060970615288 no 3078 0.0858190621406816 4387 176925 Isolated from Daphnopsis sellowiana.
SGTC_563 tetrahydrosecaminediol 614 µM -1.36982513213974 0.0896112732328675 no 3079 0.0853707474137982 4456 334274 A psychoactive constituent of the cannabis plant.
SGTC_823 0417-1665 178 µM -1.37061239751264 0.08948803924836 no 3080 0.0852479080956475 4421 3429856
SGTC_1432 4049-0298 68.4 µM -1.3718768638232 0.0892903708456636 no 3081 0.0850508869561394 4432 741646
SGTC_2285 7945142 200 µM -1.37364319923722 0.089014791558543 no 3082 0.0847762393561037 4437 2970608
SGTC_2462 5162487 171.77 µM -1.37450338833145 0.0888808164280639 no 3083 0.0846427295368076 4371 2259986
SGTC_1309 pyrazolanthrone 13.4 µM -1.37721180862919 0.0884599583772436 no 3084 0.0842233859911394 4402 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.38097162750559 0.0878781884815661 no 3085 0.0836438422859937 4471 368090
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.38197895727269 0.0877228065881328 no 3086 0.0834890811566251 4369 1241132 A phosphatase inhibitor.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.38540885616592 0.0871952773381564 no 3087 0.0829637422641067 4409 75037 A free radical scavenger.
SGTC_2721 ifenprodil 61.44 µM -1.38871813859118 0.0866885480729517 no 3088 0.0824592381621811 4423 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_605 1315-0399 119 µM -1.39373494324101 0.085924558760002 no 3089 0.0816988300416461 4502 24020461
SGTC_1261 0712-0010 12.7 µM -1.40353815315511 0.0844462276775124 no 3090 0.0802282115235211 4416 2840123
SGTC_524 r073-0010 27.8 µM -1.40423302292161 0.0843421695951474 no 3091 0.0801247356420939 4368 2772106
SGTC_4 0960-0234 25.671 µM -1.4062249556639 0.0840444071263196 no 3092 0.0798286679713958 4436 6821112
SGTC_2059 5238311 157 µM -1.41023439289485 0.0834474538772445 no 3093 0.0792352417551611 4399 703021
SGTC_2794 7785382 27.27 µM -1.41263501018247 0.0830915615171639 no 3094 0.0788815347387773 4437 2205081
SGTC_352 k048-0007 5.11 µM -1.41936722734065 0.0820995978695905 no 3095 0.0778959909161432 4381 6811911
SGTC_2058 5236698 133 µM -1.42029542622235 0.081963534452279 no 3096 0.0777608460849526 4413 766665
SGTC_3259 9138485 49.47 µM -1.42271609755273 0.0816094909751692 no 3097 0.0774092360907307 4434 17646153
SGTC_761 k216-0224 480 µM -1.42703982754749 0.080979980226551 no 3098 0.0767842074970016 4454 1340404
SGTC_2635 hydroquinidine 100 µM -1.42720241706211 0.0809563798149608 no 3099 0.0767607790064115 4375 442912 An experimental heart treatment.
SGTC_225 nsc-122657 1.016 µM -1.42899730388962 0.0806961909039259 no 3100 0.0765025041763463 4464 275685
SGTC_11 0438-0307 1.3 µM -1.43398442196764 0.0799765676273358 no 3101 0.0757883542000206 4444 4011476
SGTC_1380 2291-0730 164 µM -1.4432124624381 0.0786578064083826 no 3102 0.074480314965023 4453 2999191
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.44724569361028 0.0780866276289684 no 3103 0.0739140615124164 4480 23847180
SGTC_1747 st037496 66.6 µM -1.44942552630724 0.077779236427694 no 3104 0.0736093921676819 4422 723305
SGTC_2844 9010103 25.97 µM -1.45501086759479 0.0769958064818151 no 3105 0.0728331264510014 4445 2480525
SGTC_975 1335-0046 28.5 µM -1.45564238535775 0.0769076051707439 no 3106 0.0727457522758571 4467 16486740
SGTC_384 k007-0144 5.16 µM -1.45617486942965 0.0768332951614913 no 3107 0.0726721423779169 4410 6824886
SGTC_432 NS 1619 61.3 µM -1.45696332158203 0.0767233641866049 no 3108 0.0725632525679043 4441 4552 A K+/calcium channel activator.
SGTC_1077 5-fluorocytosine 377 nM -1.46097729945977 0.0761655636671097 no 3109 0.072010835643491 4512 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3335 9143315 29.6265 µM -1.4642040561086 0.0757194013490325 no 3110 0.0715691011562942 4482 4899691
SGTC_408 cantharidin 100 µM -1.46968679676016 0.0749658742495974 no 3111 0.0708233001318532 4458 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1349 flufenamic acid 69 µM -1.47091816023698 0.0747974295293179 no 3112 0.0706566253994154 4413 3371 A non-steroidal anti-inflammatory.
SGTC_3258 9138477 49.47 µM -1.47317117101107 0.0744899760479391 no 3113 0.0703524432531474 4505 4970355
SGTC_2211 7117706 200 µM -1.47350004669793 0.0744451773652735 no 3114 0.0703081256308805 4434 822771
SGTC_1799 st045822 46.1415 µM -1.48164684761683 0.0733419931650091 no 3115 0.0692171434019436 4462 3674992
SGTC_871 0574-0004 149 µM -1.48180354758265 0.0733208971692609 no 3116 0.0691962874448648 4440 9551173
SGTC_381 3461-2219 42.7 µM -1.48361143801767 0.0730778424735755 no 3117 0.0689560165982922 4457 2883159
SGTC_1594 piperine 70.1 µM -1.48761005315778 0.0725424549536799 no 3118 0.0684268803312122 4481 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2546 rhodinyl acetate 100 µM -1.48966979307183 0.0722678447241964 no 3119 0.0681555404335475 4443 6708682
SGTC_757 1066-0008 322 µM -1.50006896165063 0.0708935485741518 no 3120 0.0667982699836274 4520 6842497
SGTC_2057 5236571 38.335 µM -1.50066041800028 0.0708159925873504 no 3121 0.0667217078765665 4442 54684039 YBR257W POP4
SGTC_1809 st050081 57.6 µM -1.50544502160103 0.0701909957498559 no 3122 0.0661048507799868 4557 5036894
SGTC_1225 1216-0074 20.6 µM -1.506512803018 0.0700520958149775 no 3123 0.0659677914883759 4495 4241466
SGTC_1944 st076371 56.9 µM -1.51116174532091 0.0694498120685441 no 3124 0.0653736231557911 4457 24208455
SGTC_3029 9088683 49.47 µM -1.51236593883707 0.0692944575073012 no 3125 0.0652203974664852 4511 25236615
SGTC_3004 9076122 71.4286 µM -1.51643720061444 0.0687712008874656 no 3126 0.0647044192480412 4505 44782551
SGTC_440 fluspirilene 35.1 µM -1.51793687534847 0.0685792256998583 no 3127 0.0645151563858031 4519 3396 An atypical antipsychotic.
SGTC_2207 7258803 200 µM -1.5202270569934 0.0682868547044154 no 3128 0.064226959707764 4529 3666799
SGTC_1470 k295-0292 231 µM -1.52098487085707 0.0681903221649824 no 3129 0.0641318169913377 4567 5045612
SGTC_1892 st058411 7.36 µM -1.53254538226937 0.0667307365090913 no 3130 0.0626939538170354 4514 3934738
SGTC_2370 9071495 200 µM -1.53389474293142 0.066561959061608 no 3131 0.0625277747598638 4522 21791103
SGTC_1559 coumarin 343 70.1 µM -1.54011321701338 0.0657884220145758 no 3132 0.0617663793039537 4551 108770 A hepatotoxic, DNA x-linker.
SGTC_737 1950-0117 57.9 µM -1.54364065401704 0.0653527399008819 no 3133 0.0613377052866341 4526 5393513
SGTC_2090 5301565 104.445 µM -1.54528649765037 0.0651502251483908 no 3134 0.0611384899898341 4521 2056344
SGTC_2124 5246320 200 µM -1.54930352729168 0.0646579898722143 no 3135 0.0606543861205607 4522 579342
SGTC_1042 0350-0096 82 µM -1.55225774598307 0.0642978352669178 no 3136 0.0603002819351721 4509 3122515
SGTC_1495 4469-0029 237 µM -1.55313536464742 0.0641911439717272 no 3137 0.0601953994649667 4523 793680
SGTC_104 0074-0074 590.992 µM -1.55314588594905 0.0641898657420184 no 3138 0.060194142951879 4379 3943124
SGTC_31 0508-1974 57.237 µM -1.55808415850146 0.0635920974684954 no 3139 0.0596066497209115 4484 6810525
SGTC_3027 9089541 49.47 µM -1.55857327362232 0.0635331275800363 no 3140 0.0595487064079358 4517 9943819
SGTC_2421 5690543 90.72 µM -1.56178095298359 0.0631474496118166 no 3141 0.0591698001691289 4512 3397993
SGTC_2552 juarezic acid 87.02 µM -1.56300934908882 0.063000236114925 no 3142 0.0590251979188978 4478 1549512
SGTC_2714 st079313 56.9 µM -1.56377116228957 0.0629090732557512 no 3143 0.0589356594513283 4520 2939799
SGTC_2913 7966556 36.57 µM -1.57811563155785 0.0612116514406341 no 3144 0.0572695238659689 4436 2976516
SGTC_378 3970-0959 8.33 µM -1.58132583005894 0.0608367254890383 no 3145 0.0569017782758683 4548 6615653
SGTC_1752 st044819 83.042 µM -1.58265015868004 0.0606825785012615 no 3146 0.0567506121386615 4488 441209 YML126C ERG13
SGTC_1114 scopoletin 1.73284 µM -1.5854900437644 0.0603530563582999 no 3147 0.056427518624689 4567 5280460 A coumarin with genotoxic properties.
SGTC_2233 sulbentine 40.3845 µM -1.59137096953664 0.0596751252763928 no 3148 0.0557630568196826 4547 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1213 1315-0166 115 µM -1.59433017090026 0.0593362637108829 no 3149 0.0554310517431814 4538 768401
SGTC_2692 st077426 47.7 µM -1.60015260021294 0.0586739366962159 no 3150 0.0547823672228594 4531 25238571
SGTC_1121 fusaric acid 630.51 nM -1.60070228007224 0.0586117091839158 no 3151 0.0547214379624613 4517 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_883 0850-0245 24.6 µM -1.60102276569347 0.0585754519410703 no 3152 0.0546859384672609 4588 6823229 YPR165W RHO1
SGTC_1704 st028805 70.8 µM -1.60302778712316 0.0583490190008774 no 3153 0.0544642597167965 4601 2876101
SGTC_207 4185-0010 4.486 µM -1.60817141590648 0.0577712776705699 no 3154 0.0538988208051074 4606 3761753
SGTC_2226 7298446 200 µM -1.61081451119027 0.0574761550432599 no 3155 0.0536100786493586 4570 3283010
SGTC_656 4090-1979 187 µM -1.61265022157124 0.0572718821935352 no 3156 0.0534102604610047 4573 22330961
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.61285501943059 0.0572491283146841 no 3157 0.0533880047332463 4487 4000243
SGTC_2603 homopterocarpin 100 µM -1.61475198658473 0.0570387055070018 no 3158 0.0531822072715799 4539 101795 A weak amylase inhibitor.
SGTC_533 1222-0222 6.71 µM -1.6166414122307 0.0568297249933428 no 3159 0.0529778536433247 4567 3982874
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.61713708808191 0.0567750005812163 no 3160 0.0529243463350952 4582 5282309
SGTC_2438 5259590 200 µM -1.61737758119169 0.0567484642282669 no 3161 0.0528984009886174 4567 1201127
SGTC_1463 k081-0032 34.1 µM -1.61948017179172 0.0565168772732288 no 3162 0.0526719946748886 4068 977755
SGTC_2219 9098279 200 µM -1.63048223363761 0.0553171916777531 no 3163 0.0514998085570366 4509 902349
SGTC_620 0109-0052 432 µM -1.63226695714213 0.0551244918287767 no 3164 0.0513116304419779 4605 493037
SGTC_1625 st003711 30.1 µM -1.63273965923877 0.0550735422532391 no 3165 0.0512618812943713 4567 24207034 YER133W GLC7
SGTC_3012 9080433 71.4286 µM -1.63347711306709 0.0549941310652209 no 3166 0.0511843452059759 4542 17688859
SGTC_1416 3966-0321 25.3 µM -1.63647355482517 0.0546723957791504 no 3167 0.0508702579902303 4610 582530 YLR208W SEC13
SGTC_703 3875-0075 71.8 µM -1.64143382966055 0.0541430717651852 no 3168 0.0503536961445653 4601 2850814
SGTC_536 3852-0578 10.6 µM -1.6421482011393 0.0540671745418293 no 3169 0.0502796472406147 4577 2869208
SGTC_1150 3909-7983 10.9 µM -1.64229504395174 0.0540515839076076 no 3170 0.0502644368581583 4564 23965914
SGTC_2492 derrusnin 100 µM -1.64313952499955 0.0539619925067308 no 3171 0.0501770343680674 4590 1715307 Part of coumarin class of compounds.
SGTC_959 1222-0044 107 µM -1.65367172800532 0.0528544751937241 no 3172 0.0490971150146248 4555 6083612
SGTC_907 3448-6986 75.5 µM -1.65758501614192 0.0524475960108107 no 3173 0.0487006280439177 4583 590582
SGTC_3141 9094609 49.47 µM -1.65872465007533 0.0523295726797055 no 3174 0.0485856449377176 4525 25236309 YDL196W YDL196W
SGTC_3146 9095609 49.47 µM -1.66189405128724 0.0520024501362482 no 3175 0.048267009828785 4608 17173999
SGTC_2165 5727197 32.143 µM -1.66312040140607 0.0518763119754271 no 3176 0.0481441684287921 4599 1361712
SGTC_1529 apigenin 74 µM -1.66369517677904 0.0518172762987881 no 3177 0.04808668032341 4559 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1949 st076024 69.1 µM -1.66523269001962 0.0516596194092199 no 3178 0.0479331707151206 4543 2921930
SGTC_1080 nisoldipine 24.4 µM -1.66643450607571 0.0515366507056725 no 3179 0.0478134514125724 4593 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.66715252423886 0.0514632948945099 no 3180 0.0477420401169023 4544 364106
SGTC_1314 1222-0010 41.1 µM -1.6771359463487 0.0504519259225698 no 3181 0.046757950505849 4579 3526027
SGTC_407 eburnamonine 100 µM -1.68182932482531 0.0499819680119837 no 3182 0.0463009702729926 4441 3195
SGTC_2132 5317594 122.667 µM -1.68464580016609 0.0497016286271681 no 3183 0.0460284646551401 4517 794577
SGTC_2116 5511452 16.8835 µM -1.6878908587355 0.0493801869353124 no 3184 0.0457160908655424 4586 870744
SGTC_2079 5212404 121 µM -1.6903923684855 0.049133532593836 no 3185 0.0454764570515463 4539 758462
SGTC_204 PMA1.184 62.41 µM -1.69306558427132 0.04887103635795 no 3186 0.0452214921238453 4565 2252213 YGL008C PMA1
SGTC_1057 3448-5381 134 µM -1.70295078985084 0.047910079763401 no 3187 0.0442886389996859 4576 5497911
SGTC_694 1315-0438 43.2 µM -1.71285779718191 0.0469622396558323 no 3188 0.0433693520037381 4623 6793154
SGTC_1560 lithocholic acid 53.1 µM -1.71483728989532 0.0467746688330938 no 3189 0.0431875313163368 4548 9903 A bile acid which acts as a detergent.
SGTC_3312 9133330 71.43 µM -1.71644565179049 0.0466227082051405 no 3190 0.0430402535557561 4605 17617324
SGTC_1087 pterostilbene 9.05 µM -1.71646750009909 0.0466206466722068 no 3191 0.0430382557021896 4588 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1130 3454-2858 15.9 µM -1.71813515194981 0.0464635084001939 no 3192 0.0428859832128344 4554 715628 YIL048W NEO1
SGTC_2596 sinensetin 100 µM -1.72005287037891 0.0462833328817462 no 3193 0.0427114157807926 4587 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2581 avocatin a 64 µM -1.72160882625597 0.0461375586745051 no 3194 0.0425702016201216 4534 6710728 A skin care supplement.
SGTC_2655 perillic acid 100 µM -1.73146984386301 0.0452222552796701 no 3195 0.0416839994541209 4648 5702197 An apoptosis inducer.
SGTC_2405 ticlatone 3.52 µM -1.7318182040507 0.0451901894717867 no 3196 0.0416529679506135 4404 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_943 3253-1379 105 µM -1.73834021122488 0.0445932231873053 no 3197 0.0410754424732526 4575 668464
SGTC_1393 3470-5649 58.2 µM -1.74810069218744 0.0437117192916531 no 3198 0.0402232965826642 4614 4108395
SGTC_2873 9040596 71.43 µM -1.75115850615233 0.0434384676587401 no 3199 0.0399593053344834 4571 6463863
SGTC_2453 5731132 22.18 µM -1.75480725759935 0.0431142150382062 no 3200 0.0396461408871589 4635 1362040
SGTC_3032 9089427 49.47 µM -1.75667337620744 0.0429491364339935 no 3201 0.0394867490299698 4584 17173707
SGTC_898 1000-0849 28.3 µM -1.77734136671604 0.0411547685395621 no 3202 0.0377560457164659 4622 6751807
SGTC_727 3032-0951 202 µM -1.78385604257697 0.0406019404077561 no 3203 0.0372235301301727 4643 3652836
SGTC_318 1488-0629 67.2 µM -1.78539647363865 0.0404721061789561 no 3204 0.0370985151203496 4674 3662576
SGTC_2205 7238770 200 µM -1.79914790363061 0.0393279513922229 no 3205 0.0359976438652943 4658 279867
SGTC_690 glyoxal 20.3 µM -1.80030271858483 0.0392330778897162 no 3206 0.0359064259433048 4437 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_290 2043-6722 48.1 µM -1.8040093477826 0.0389298185320242 no 3207 0.0356149207736916 4640 773758 YLR208W SEC13
SGTC_102 gallobenzophenone 83.616 µM -1.80525395568091 0.0388284195485289 no 3208 0.035517475616304 4612 70837
SGTC_2971 9092186 9.93 µM -1.80619278193374 0.0387520752041274 no 3209 0.0354441160045705 4588 25236400
SGTC_1781 st038725 66.3 µM -1.81603405739453 0.0379591297603437 no 3210 0.0346825739777953 4626 4270275 YIL048W NEO1
SGTC_2771 fluoxetine 41.05 µM -1.81844457325163 0.037766938081989 no 3211 0.0344981054787901 4626 3386 A selective serotonin reuptake inhibitor.
SGTC_710 3448-4187 58 µM -1.81889136825344 0.037731402282828 no 3212 0.0344640024987197 4599 3946412
SGTC_677 0929-0063 136 µM -1.8269912680111 0.0370918964683864 no 3213 0.0338505411519411 4667 1539583
SGTC_2214 7179297 48.276 µM -1.82904592937737 0.0369310925111432 no 3214 0.0336963640108501 4691 769744
SGTC_2325 6158266 200 µM -1.82953164670491 0.0368931622261045 no 3215 0.0336600014543014 4601 3623240
SGTC_3203 9113543 49.47 µM -1.83340151124767 0.0365920960721786 no 3216 0.0333714415212954 4627 17018012
SGTC_2742 clothiapine 36.27 µM -1.83608474776544 0.0363845290008327 no 3217 0.0331725618446703 4676 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2411 st077133 39.94 µM -1.84077108426077 0.0360243199334567 no 3218 0.0328275559618815 4599 1403142 YNL221C POP1
SGTC_2232 chlorophetanol 41.5365 µM -1.84386781353054 0.0357879005144418 no 3219 0.0326012034193053 4702 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2935 9038016 29.96 µM -1.85987511309376 0.0345860152709996 no 3220 0.0314515985557813 4594 6463195
SGTC_1490 4089-0339 670 nM -1.86433639183456 0.0342570181526556 no 3221 0.0311372396599867 4658 742542
SGTC_3033 9090887 49.47 µM -1.86968512881065 0.0338659707341755 no 3222 0.0307637779161883 4660 19325384
SGTC_837 0091-0265 12.5 µM -1.8710733471457 0.0337650801611547 no 3223 0.030667457639796 4668 759367
SGTC_2360 9040895 200 µM -1.87244976308445 0.0336652916260389 no 3224 0.0305722029491235 4662 4914414
SGTC_357 1325-0123 420 µM -1.87382959701257 0.0335654990200512 no 3225 0.0304769578114852 4629 1098503
SGTC_3298 9116858 71.43 µM -1.88142297732409 0.0330206770919 no 3226 0.0299572018315276 4681 2506942
SGTC_214 4373-3496 70 µM -1.88348602724702 0.032873919519568 no 3227 0.0298172658346013 4693 3779166
SGTC_66 0109-0187 42.4 µM -1.88849611964859 0.0325197576850952 no 3228 0.0294796891784603 4492 759417
SGTC_1348 1493-0373 93.8 µM -1.89159610221799 0.0323022013461594 no 3229 0.0292724078150787 4662 3010129
SGTC_2761 levamisole 97.89 µM -1.90262125465495 0.031538168863406 no 3230 0.0285449918446139 4654 26879 An alkaline phosphatase inhibitor.
SGTC_1565 sinapyl alcohol 95.1 µM -1.91273759844458 0.0308503163874715 no 3231 0.0278908266467895 4659 5280507 A phenol propionate derived from cinnamic acid.
SGTC_607 4491-0986 66.8 µM -1.91773772278678 0.0305149502787724 no 3232 0.0275721379808225 4658 698981 YDR232W HEM1
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.92938732715876 0.0297452957978665 no 3233 0.0268413978925795 4675 5393153
SGTC_1729 st035615 45.989 µM -1.92953541866329 0.0297356164819484 no 3234 0.0268322137236706 4642 17385451
SGTC_2018 5133068 143 µM -1.93144603158068 0.0296109722989416 no 3235 0.026713958638456 4634 785362
SGTC_111 0083-0039 52.457 µM -1.93343534817555 0.0294816547581145 no 3236 0.0265912951368819 4650 759313
SGTC_112 phenothiazine 287.218 µM -1.93372645237952 0.0294627706164267 no 3237 0.0265733848502519 4641 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1710 st031758 61.5 µM -1.9379044172053 0.0291928475494886 no 3238 0.0263174424834735 4690 5394341
SGTC_2000 st075254 36.4 µM -1.93809818654344 0.0291803788290951 no 3239 0.0263056223367973 4590 17234175
SGTC_3302 9125395 16.351 µM -1.93832743277196 0.0291656329458233 no 3240 0.0262916437913702 4630 17599668
SGTC_2652 actinonin 100 µM -1.94761071204895 0.0285736819646515 no 3241 0.0257307805175043 4718 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3229 9132204 49.47 µM -1.95005086036228 0.0284197545806981 no 3242 0.0255850286635988 4743 17682924
SGTC_789 1309-1135 70.6 µM -1.9520598319886 0.0282935447437989 no 3243 0.0254655507299951 4655 3092424
SGTC_217 ketoconazole 989 nM -1.9580524067794 0.0279198408171711 no 3244 0.025111931779742 4494 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.95897101153739 0.0278629206178631 no 3245 0.0250580908765581 4721 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.96780450866048 0.027320482659848 no 3246 0.0245452676152722 4682 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2350 9023895 38.85 µM -1.97261472027792 0.0270288250929883 no 3247 0.0242697373054626 4632 2997209
SGTC_2522 biochanin a 4.94 µM -1.97589036019338 0.0268317041729265 no 3248 0.0240835981132681 4657 5280373 A possible chelator.
SGTC_1307 1187-1599 12.2 µM -1.99152481982598 0.0259073201466707 no 3249 0.0232116096738611 4700 1538471
SGTC_3040 9091894 49.47 µM -1.99775870204876 0.0255462477790596 no 3250 0.0228714133139781 4619 25236966
SGTC_1798 st045719 60.953 µM -2.00654466450106 0.0250445187950351 no 3251 0.0223990842023064 4661 3980186
SGTC_586 0957-0265 8.15 µM -2.03732073204751 0.0233517141769332 no 3252 0.0208089557886719 4623 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1205 4161-2785 76 µM -2.03828142638237 0.0233004612816292 no 3253 0.0207608981422563 4670 3498106
SGTC_699 0375-0592 111 µM -2.04249740290295 0.0230766576623357 no 3254 0.0205511083901304 4741 762578
SGTC_933 2914-0560 114 µM -2.04941521982322 0.0227133507418726 no 3255 0.0202107651185974 4697 463887
SGTC_1623 st003709 20.3 µM -2.06869764863763 0.0217260405840891 no 3256 0.0192872340033528 4689 16192618
SGTC_1521 st012942 49.4 µM -2.07098814833721 0.0216112068865451 no 3257 0.0191799518131326 4628 24207259
SGTC_1360 1598-0022 39.8 µM -2.07687548235032 0.0213183978288083 no 3258 0.0189065265860237 4706 761525
SGTC_964 1287-0107 19.4 µM -2.07845788818676 0.0212402706520112 no 3259 0.0188336028608322 4691 51516812 YPR165W RHO1
SGTC_2261 9010538 184.68 µM -2.08117918845723 0.0211064798354358 no 3260 0.0187087538614086 4677 6457250
SGTC_1790 st045711 43.5 µM -2.08735390834152 0.0208055464402536 no 3261 0.0184280775595522 4705 585119
SGTC_2936 9038235 15.59 µM -2.08859855138059 0.0207453290426316 no 3262 0.0183719378516667 4636 4749415
SGTC_49 0717-0965 32.132 µM -2.10403943438291 0.0200104708148544 no 3263 0.0176875036325052 4726 5889349 YGL099W LSG1
SGTC_2225 6654152 15.4 µM -2.10570491006184 0.0199325437074509 no 3264 0.0176149965325675 4693 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_131 0141-0277 33.849 µM -2.11831861601722 0.0193506708083874 no 3265 0.0170740465393979 4660 1547771
SGTC_1475 4092-1048 11.7 µM -2.12907137493081 0.0188661012665681 no 3266 0.0166241778208869 4706 2881759
SGTC_2320 7373003 200 µM -2.13629522668717 0.018546390412842 no 3267 0.0163276788566435 4673 5415828
SGTC_1214 0358-0031 63.7 µM -2.14969812280297 0.0179654206534016 no 3268 0.0157895505219483 4698 4301366
SGTC_353 1988-1175 58.3 µM -2.15365684258151 0.0177968209080168 no 3269 0.0156335464973089 4570 2788357
SGTC_2551 apiole 73.87 µM -2.15463019991725 0.0177555734964253 no 3270 0.0155953919204078 4686 10659 A possible DNA adduct former.
SGTC_843 0310-0051 143 µM -2.16177817023642 0.0174551595494183 no 3271 0.015317639449224 4733 2065037
SGTC_444 curcumin 90.4 µM -2.16271146646752 0.0174162572713406 no 3272 0.015281689311065 4628 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3054 9094397 49.47 µM -2.16671104775211 0.0172503814534905 no 3273 0.015128446836801 4694 2598354
SGTC_2686 alizarin 95.37 µM -2.17757234743173 0.016806721477766 no 3274 0.0147189450659406 4689 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_850 0388-0143 75.9 µM -2.19136740934867 0.0162573242091857 no 3275 0.0142126077774955 4744 67273
SGTC_1579 chlormadinone acetate 49.4 µM -2.19332982045001 0.0161804336640597 no 3276 0.0141418123083946 4751 45114258 A steroidal progestin.
SGTC_1717 st033143 58.0435 µM -2.19438265105603 0.0161393105695672 no 3277 0.0141039560360294 4705 674616
SGTC_527 4476-4215 268 µM -2.19866359718087 0.0159730198375745 no 3278 0.0139509256059056 4719 4418754
SGTC_1646 st011709 75.6 µM -2.20049314062908 0.0159024015804408 no 3279 0.013885963037426 4701 5757843
SGTC_1331 1472-0049 76.2 µM -2.20446312963659 0.0157500847755565 no 3280 0.0137458950915437 4724 24051409
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.21308597559933 0.0154235573790608 no 3281 0.013445859400348 4705 115019
SGTC_2080 5212524 12.4 µM -2.23449415866653 0.0146379037894153 no 3282 0.0127252882326489 4700 260183
SGTC_1660 st012960 28.1 µM -2.2361331546403 0.0145791996134301 no 3283 0.0126715251269333 4748 24207266
SGTC_3099 9120367 49.47 µM -2.23810324872099 0.0145089046736724 no 3284 0.0126071614296382 4751 24824940
SGTC_356 1634-0012 32.5 µM -2.26140083683177 0.0136995006954372 no 3285 0.0118672234982761 4730 735457
SGTC_604 1000-0114 314 µM -2.2634330865768 0.0136307803450718 no 3286 0.0118045025416413 4748 1572745
SGTC_2445 5742597 35.57 µM -2.26608160526467 0.0135416675176587 no 3287 0.0117231936374931 4726 1774255
SGTC_129 0088-0017 176.636 µM -2.27245314059269 0.0133293464784682 no 3288 0.0115295775969867 4628 182446
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.28421908082791 0.0129448158584897 no 3289 0.0111793293643044 4706 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1411 3909-8223 150 µM -2.29749566371662 0.0125224685694433 no 3290 0.0107952550759451 4774 X1411
SGTC_2570 licareol 100 µM -2.3120567428315 0.0120730275816978 no 3291 0.0103872782717713 4705 443158
SGTC_58 0957-0393 9 µM -2.31984857661035 0.0118383201021434 no 3292 0.0101745351031222 4278 6997992
SGTC_1203 3992-3522 103 µM -2.32842893890923 0.0115844501798415 no 3293 0.0099446692471062 4719 5322312
SGTC_45 0kpi-0036 14.9 µM -2.34785984413436 0.011026953946044 no 3294 0.00944081236233561 4696 2795021
SGTC_5 0352-0601 109.883 µM -2.35309630566191 0.0108807649884119 no 3295 0.0093089057335871 4669 762456
SGTC_383 2324-0395 7.37 µM -2.37120522322787 0.01038813405723 no 3296 0.00886509166769292 4737 3146421
SGTC_670 4204-0025 119 µM -2.37252569617836 0.0103529850054369 no 3297 0.00883346710336902 4735 719039
SGTC_1654 st012436 41.8 µM -2.37779446969674 0.0102137681801845 no 3298 0.0087082652814021 4772 4323132
SGTC_2493 resveratrol 26.09 µM -2.39972807171359 0.00965161707887859 no 3299 0.00820362761835744 4744 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1651 st011928 86.1 µM -2.40521505668527 0.00951528833603438 no 3300 0.0080814755362987 4755 720198
SGTC_2171 5739187 198.077 µM -2.40907385120564 0.00942042452039592 no 3301 0.00799653067600869 4729 2262761
SGTC_1245 0418-0076 17.2 µM -2.42993370643749 0.00892179963569988 no 3302 0.00755079238445739 4741 6790114
SGTC_625 k213-0058 121 µM -2.45447797893091 0.00836484334784426 no 3303 0.00705446528356776 4784 3655420
SGTC_2067 5224629 34.075 µM -2.46094228545677 0.00822333250557919 no 3304 0.00692863277629648 4741 2835000
SGTC_723 4182-0001 115 µM -2.46291414412607 0.00818058697941587 no 3305 0.00689064559064235 4742 744821 YLR208W SEC13
SGTC_1813 st051246 8.6015 µM -2.4877715111922 0.0076582431890404 no 3306 0.00642731451933161 4754 5291959
SGTC_72 0744-0168 198.391 µM -2.48844331815247 0.00764454317592011 no 3307 0.00641518437831052 4702 677577
SGTC_955 1216-0110 33 µM -2.49405366878118 0.00753097250372495 no 3308 0.00631467236417484 4733 3619719
SGTC_128 0906-2981 13.371 µM -2.51225769052434 0.0071726361283392 no 3309 0.00599807278493148 4757 6740226
SGTC_1650 st011916 45.8 µM -2.51931717802952 0.00703777360513176 no 3310 0.00587913422434842 4764 242528
SGTC_926 2268-1401 59.4 µM -2.53503145183258 0.00674557960811751 no 3311 0.00562186152288738 4747 2931578
SGTC_311 1315-0136 58 µM -2.54255809058777 0.0066094639341296 no 3312 0.00550221536340476 4777 6759207
SGTC_1224 0823-0416 294 µM -2.55271158101508 0.00642969271234529 no 3313 0.00534439834783234 4773 3598164
SGTC_2517 totarol 10 µM -2.55469615099739 0.0063950650118747 no 3314 0.005314026437127 4765 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2525 harmine 47.85 µM -2.56787119946196 0.00616933640718768 no 3315 0.00511625842261194 4781 5280953 A monoamine oxidase inhibitor
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.6737872115808 0.00459659409017051 no 3316 0.00375000116165457 4748 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_961 1252-1571 372 µM -2.67412652072203 0.00459219194583238 no 3317 0.00374620894602106 4770 6813498
SGTC_2795 7780010 54.55 µM -2.68948470275694 0.00439683533510228 no 3318 0.00357812134224825 4753 953673
SGTC_2177 5811945 192 µM -2.68979654928048 0.0043929467435044 no 3319 0.00357477961003748 4756 5343475
SGTC_1673 st016611 27.3 µM -2.69550881679103 0.00432225882604046 no 3320 0.00351406088928135 4767 5226799
SGTC_1234 0326-0494 15.5 µM -2.7586315158361 0.00360619434356476 no 3321 0.00290219719671807 4790 1547813
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.76214594449009 0.00356965180605341 no 3322 0.00287114019911372 4766 229346 A bile salt which induces apoptosis.
SGTC_2611 pyromycin 23.93 µM -2.76577335864365 0.00353228341185597 no 3323 0.00283939936646435 4748 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1039 k821-0043 94 µM -2.7684345719164 0.00350509226447109 no 3324 0.00281631469858101 4735 15992768
SGTC_2887 9044784 58.44 µM -2.79449554429079 0.00324858164071535 no 3325 0.00259903785488588 4740 6465546
SGTC_130 0136-0219 337.655 µM -2.80028341927729 0.00319395728634563 no 3326 0.00255288782880405 4749 234244
SGTC_2387 9077560 195.08 µM -2.8225840553207 0.00299113394308212 no 3327 0.00238191661984459 4780 5303272
SGTC_887 0885-0007 9.62 µM -2.83023844074863 0.00292424014479403 no 3328 0.00232566626906717 4778 5719458
SGTC_3352 9151559 45.5865 µM -2.86129119542379 0.00266647849219712 no 3329 0.00210959663497659 4780 17159339
SGTC_2649 anisomycin 9.56 µM -2.92670901860855 0.00218942394818458 no 3330 0.001712846130257 4798 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_540 1187-0821 17.3 µM -2.93131000298975 0.00215897864300794 no 3331 0.00168767883485344 4762 847520
SGTC_1519 esterone 74 µM -3.01766208112485 0.00165436642892216 no 3332 0.00127366389638294 4787 698 A steroid.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -3.04898769342531 0.00149966885657106 no 3333 0.00114806943748147 4792 7104
SGTC_808 0711-0032 135 µM -3.13095268488974 0.00115526563636604 no 3334 0.000871201152743577 4791 4252555
SGTC_530 4358-1714 28 µM -3.14133804457923 0.00111723140454056 no 3335 0.000840888971005363 4789 1564641
SGTC_1247 0448-0043 5.84 µM -3.14452644147384 0.00110578686757168 no 3336 0.000831779385478034 4772 3089013 YGL099W LSG1
SGTC_2141 5621638 7.665 µM -3.23659540442763 0.00081824511321229 yes 3337 0.000604823919260502 4802 2856238
SGTC_358 0075-0058 9.45 µM -3.26373468534687 0.000747682263375666 yes 3338 0.000549770390352554 4772 1069125
SGTC_2304 7443016 91.4 µM -3.26738768988229 0.00073862472076833 yes 3339 0.000542724622207983 4786 939854
SGTC_2796 7949634 45.45 µM -3.32067346392362 0.000617497807363742 yes 3340 0.000449002676575402 4791 2971588
SGTC_924 2046-0044 21.3 µM -3.35208898098181 0.000554967632127661 yes 3341 0.000401021180828677 4786 3623589
SGTC_2588 indole-3-carbinol 100 µM -3.70998159923104 0.000154674697702822 yes 3342 0.000103637155920507 4800 3712 Induces cell cycle arrest.
SGTC_995 3931-2021 34.6 µM -3.76129525940148 0.000127597047245777 yes 3343 8.45178763466434e-05 4794 730143
SGTC_50 0929-0078 56.389 µM -3.86642939858132 8.53953212806634e-05 yes 3344 5.52202080549784e-05 4792 1377751
SGTC_2772 vinpocetine 57.06 µM -3.86956780930746 8.43649970075661e-05 yes 3345 5.45142275045919e-05 4799 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1933 st074711 15.9 µM -3.89353709085409 7.68730807570086e-05 yes 3346 4.93965444520042e-05 4799 17250958
SGTC_2174 5790901 200 µM -3.95891333121244 5.94961034983115e-05 yes 3347 3.76457752776298e-05 4804 786020
SGTC_2430 5571206 200 µM -4.06529319378672 3.88932004374213e-05 yes 3348 2.39860581535586e-05 4797 1731771
SGTC_3304 9125678 46.087 µM -4.10367894893905 3.3279934054631e-05 yes 3349 2.03315828200847e-05 4805 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2428 5615643 7.78 µM -4.11052321539861 3.23633144752195e-05 yes 3350 1.97381793024794e-05 4806 2253075
SGTC_2587 piperic acid 92.2 µM -4.93806787272214 8.11096353803502e-07 yes 3351 3.94501920854294e-07 4806 5370536
SGTC_2313 7726885 200 µM -5.46069753174914 5.75137761644835e-08 yes 3352 2.37133735197474e-08 4808 726423
SGTC_2312 7706453 155.7 µM -7.22686186224346 1.19110797750125e-12 yes 3353 2.4714120556899e-13 4809 976098