SGTCid condition conc unit GNA1|YFL017C.score GNA1|YFL017C.strain.pval GNA1|YFL017C.strain.significant GNA1|YFL017C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2998 9066762 71.4286 µM 7.47535822507477 5.20176758033546e-15 yes 1 3.84969131466346e-14 1 4945196 SGTC_165 k038-0023 64.381 µM 6.22544998849732 5.98845329560912e-11 yes 2 2.40087905128639e-10 9 46368543 SGTC_705 1124-0212 310 µM 5.78623047761644 1.08393932674298e-09 yes 3 3.59917169171774e-09 1 9554485 SGTC_1324 1418-0026 34.4 µM 5.33705523417261 1.70016542484351e-08 yes 4 4.72341344764511e-08 1 1372513 SGTC_1361 1608-0041 5.61 µM 4.94525821282944 1.57988648158476e-07 yes 5 3.80215005116963e-07 2 X1361 SGTC_3029 9088683 49.47 µM 4.8085300128602 3.31256480345729e-07 yes 6 7.60221020556556e-07 1 25236615 SGTC_676 falcarinol 140 µM 4.63846310565117 8.09752941437417e-07 yes 7 1.75504788873283e-06 7 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2180 6301957 200 µM 4.21269141719584 6.65641492002063e-06 yes 8 1.2617285240498e-05 9 845462 SGTC_95 0471-0001 561.058 µM 4.11798103548777 1.03685849347603e-05 yes 9 1.91103069928593e-05 4 4015405 SGTC_3108 9121785 49.47 µM 4.02878882730915 1.56071950987946e-05 yes 10 2.80324752709344e-05 11 17140271 SGTC_2709 st078560 56 µM 3.97212706789275 2.01517310289572e-05 yes 11 3.56168513030601e-05 6 17250903 SGTC_1347 1493-0251 600 nM 3.89203539922629 2.87578878258667e-05 yes 12 4.97033681179145e-05 6 3986378 SGTC_139 0099-0334 718.624 µM 3.82312674849187 3.88468266222495e-05 yes 13 6.58849999668809e-05 7 97690 SGTC_1673 st016611 27.3 µM 3.81322014259515 4.05468999747937e-05 yes 14 6.85839149568575e-05 7 5226799 SGTC_505 gw-5074 63.9 µM 3.80759051187316 4.15440928532908e-05 yes 15 7.01636925418918e-05 7 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1306 1185-0270 9.02 µM 3.7875036222455 4.52943048122311e-05 yes 16 7.60842336598412e-05 12 1548076 SGTC_1345 1488-0192 31.4 µM 3.721750249664 5.99320543848009e-05 yes 17 9.89233288269767e-05 2 658348 SGTC_333 3486-0131 40.1 µM 3.70803113080547 6.35026957944377e-05 yes 18 0.000104438491252358 4 6744690 SGTC_81 0411-0046 9.971 µM 3.70761035157335 6.36153175655236e-05 yes 19 0.000104612126673857 41 12925265 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 3.69498051157538 6.70846498558989e-05 yes 20 0.000109951826728092 12 6728940 SGTC_3105 9121040 49.47 µM 3.62757574589791 8.88193480904148e-05 yes 21 0.000143047428863888 3 41448907 SGTC_135 0933-0004 26.348 µM 3.48640956970075 0.000157495685387392 yes 22 0.000244775432664759 10 21230617 YGL099W LSG1 SGTC_2765 myclobutanil 7.74 µM 3.43671734969714 0.000191754395853971 yes 23 0.00029440485724051 16 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2245 6637752 200 µM 3.41549652834106 0.000208409078661913 yes 24 0.000318329205100692 8 681890 SGTC_1691 st019933 84.6 µM 3.36559579936998 0.000253042427215852 yes 25 0.000381892698933983 3 6176082 SGTC_356 1634-0012 32.5 µM 3.26392811984182 0.000372835046426638 yes 26 0.000549395190818122 12 735457 SGTC_2997 9067075 71.4286 µM 3.26197744601128 0.000375579614262379 yes 27 0.000553189728993266 31 27209819 SGTC_1714 st033236 13.627 µM 3.20708733606265 0.000460945988719434 yes 28 0.000670431408038354 16 2916566 SGTC_133 0724-0033 378.92 µM 3.20313593971974 0.000467737644189071 yes 29 0.000679698980673039 14 280309 SGTC_632 0781-2353 4.65 µM 3.2013976980567 0.000470754595009393 yes 30 0.000683813144387878 27 6811515 YHR007C ERG11 SGTC_953 1188-0045 9.7 µM 3.20030350588463 0.000472662946774621 yes 31 0.000686414704394197 18 6144426 SGTC_1334 1486-0610 236 µM 3.19547226121774 0.000481174976860596 yes 32 0.000698011007974471 10 3742339 SGTC_1003 4049-0218 100 µM 3.12725415153388 0.000617542722893094 yes 33 0.000882236615854822 24 295161 SGTC_1678 st019265 80.2 µM 3.10765409234588 0.000662866363962115 yes 34 0.000942893235786099 14 5367020 SGTC_1995 st072814 61.1 µM 3.08563062334822 0.000717444456458245 yes 35 0.00101560491576865 6 5769371 SGTC_2589 lobaric acid 100 µM 3.07083139476675 0.000756415112477987 yes 36 0.00106731827114853 9 73157 A novel microtubule depolymerizer. SGTC_2395 5646831 180.19 µM 3.0676820703937 0.000764955880156428 yes 37 0.0010786299953229 10 6808628 SGTC_473 2-arachidonoylglycerol 10 µM 3.03418873346964 0.000861445893895304 yes 38 0.00120591747414241 15 5282280 An endocannabinoid. SGTC_1410 3909-8106 77.9 µM 2.97840135317628 0.0010473154228342 no 39 0.00144878142426238 8 1039210 SGTC_1168 k815-0004 80.5 µM 2.96028762862751 0.00111515895298046 no 40 0.00153675972217053 35 642433 SGTC_3116 9124943 49.47 µM 2.92812297324815 0.00124563407856356 no 41 0.00170507569906564 13 41905195 YPL160W CDC60 SGTC_2010 4012422 159 µM 2.92112576035261 0.001275806639753 no 42 0.00174384505827491 10 952393 SGTC_3119 9125183 49.47 µM 2.92021313473939 0.00127979085238809 no 43 0.0017489603398742 10 22695334 SGTC_7 0192-1582 4.227 µM 2.90922414570024 0.00132866657541572 no 44 0.00181163491462772 18 252616 SGTC_3337 9144342 33.5465 µM 2.88788808494832 0.00142846589570443 no 45 0.00193918919322913 25 17682949 SGTC_9 0092-0002 10.449 µM 2.88591990505085 0.00143800853014908 no 46 0.00195135731785687 29 759368 SGTC_2487 5918373 44.05 µM 2.87292624276774 0.00150248197319113 no 47 0.00203344526007835 14 2876279 SGTC_1991 st073000 8.92 µM 2.86880591097307 0.00152347081350172 no 48 0.00206012273425889 34 4301969 YIL048W NEO1 SGTC_612 0302-0167 22.4 µM 2.8403930336131 0.00167563893501497 no 49 0.00225289906021778 21 235821 SGTC_1488 4013-0813 75.9 µM 2.83345862585194 0.00171481945668028 no 50 0.0023023634215479 5 2910057 SGTC_46 0329-0187a 2.197 µM 2.81773747481605 0.00180675295185384 no 51 0.00241816677227971 28 46494817 SGTC_1219 1469-0211 33.1 µM 2.77926425738038 0.00205093961438365 no 52 0.00272410916107753 15 6822282 SGTC_2163 5671233 125 µM 2.72553477451393 0.00244214112566774 no 53 0.00320987067600328 37 701023 SGTC_888 0916-0002 6.97 µM 2.7237217225278 0.00245644751102265 no 54 0.00322754352814293 14 2802138 YIL048W NEO1 SGTC_751 0833-0568 350 µM 2.71367411093126 0.0025371139692475 no 55 0.00332707952967138 14 6954252 SGTC_1671 st016596 74.5 µM 2.7104802915197 0.00256325238609165 no 56 0.00335929206209474 14 2829167 SGTC_2035 5154463 94.595 µM 2.70964614253688 0.00257011907752575 no 57 0.00336775124303588 32 2769623 SGTC_164 4100-3994 89.624 µM 2.69609804588426 0.00268399890161162 no 58 0.00350785065545687 23 4615967 SGTC_3190 9110366 49.47 µM 2.66937824004284 0.00292204102458339 no 59 0.00379959100478974 17 17123768 SGTC_3044 9093193 49.47 µM 2.66797472759355 0.00293505532923806 no 60 0.0038154998959841 29 25236277 SGTC_1350 1495-0454 146 µM 2.64369451574348 0.00316862232040973 no 61 0.00410033156037792 18 1069057 SGTC_700 3453-2283 142 µM 2.64295237592776 0.00317601781617795 no 62 0.00410932971793809 30 565664 SGTC_619 1652-1634 108 µM 2.62769049589189 0.00333158861209608 no 63 0.00429833465264816 15 5400454 SGTC_631 k072-0230 41.5 µM 2.61891862892345 0.00342407289034481 no 64 0.00441044928536137 21 5773147 SGTC_818 4072-2707 53.5 µM 2.60980158816624 0.00352263499813329 no 65 0.00452973753598952 31 882871 SGTC_2282 7944268 200 µM 2.59786966134858 0.00365547454821179 no 66 0.00469020461168358 31 2970414 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.58971890168422 0.00374878401959254 no 67 0.00480271655138229 31 688798 SGTC_514 4466-0038 2.65 nM 2.56424167384214 0.00405437325337349 no 68 0.00517007593641696 69 5722064 SGTC_2138 5575593 77.673 µM 2.56079778354428 0.00409734849269519 no 69 0.00522160611096353 12 762213 SGTC_84 0443-0269 128.823 µM 2.56034488882379 0.00410303025168379 no 70 0.00522841656250633 12 6150058 SGTC_902 1120-0002 2.07 µM 2.53322197953021 0.00445642373030724 no 71 0.00565096779353093 36 3280475 SGTC_570 0987-0065 62.6 µM 2.51872149750469 0.00465629878744434 no 72 0.00588908884494541 21 3104428 SGTC_1861 st057647 17.4 µM 2.51855498625732 0.00465863970602038 no 73 0.00589187414340693 19 688668 SGTC_1955 wogonin 32.4 µM 2.49519355321884 0.004997663531477 no 74 0.00629442204743166 24 5281703 A flavanone. SGTC_1872 amphotericin b 148 nM 2.48770506665902 0.0051108964170527 no 75 0.00642851534344548 36 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1023 4482-3888 16 µM 2.48283687131889 0.00518572756217136 no 76 0.00651703806542085 31 3303168 SGTC_252 miconazole 1.30953 nM 2.4632598512529 0.00549659195647564 no 77 0.00688400464296824 54 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_504 lovastatin 124 µM 2.46223859352843 0.00551325375419037 no 78 0.00690363908028779 32 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2539 epi(13)torulosol 80 µM 2.45857461039699 0.00557340146137812 no 79 0.00697448944345814 30 6708597 SGTC_83 0170-0301 39.027 µM 2.45012376319351 0.00571435766647573 no 80 0.00714035597313236 7 3089716 SGTC_1635 st007035 42.4 µM 2.4476152895207 0.00575680250361923 no 81 0.0071902555012943 48 3716403 SGTC_3017 9080681 49.47 µM 2.44084106119317 0.00587282767119063 no 82 0.00732655109777551 18 16451914 SGTC_1827 berberine 7.24 µM 2.43914159352085 0.00590225869829924 no 83 0.00736109923285092 27 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2113 5491891 107.031 µM 2.43463426267699 0.00598095017983564 no 84 0.00745342420755762 36 789979 SGTC_2823 7987624 58.44 µM 2.42346909610782 0.00617989708275187 no 85 0.00768653060065231 48 2239440 SGTC_1353 1498-1206 8.11 µM 2.41531191043854 0.00632892980048838 no 86 0.00786087004251873 34 6756808 SGTC_1357 1503-1303 39.5 µM 2.41157163755281 0.00639832251957666 no 87 0.00794196554740093 39 292895 SGTC_975 1335-0046 28.5 µM 2.39699997333593 0.00667513186081959 no 88 0.00826496245804095 33 16486740 SGTC_2436 5633522 8.09 µM 2.37488765623375 0.00711541394134166 no 89 0.00877714607691792 48 5724242 SGTC_851 0394-0702 453 µM 2.37395958323206 0.00713444059933702 no 90 0.00879923835778707 59 762646 SGTC_1831 st055328 12 µM 2.36725806435153 0.00727316734542949 no 91 0.00896021616179186 40 1103068 SGTC_665 3914-0008 307 µM 2.36355140535882 0.00735091519187078 no 92 0.00905035764993448 27 1069549 SGTC_206 4546-0025 72.014 µM 2.36227629248418 0.00737782976023886 no 93 0.00908154993626934 37 6620745 YIL048W NEO1 SGTC_2804 7954240 19.48 µM 2.36198420913927 0.00738400714971985 no 94 0.00908870822545246 34 828705 SGTC_2044 5102272 200 µM 2.35402968471336 0.00755400236654103 no 95 0.00928556398282181 41 592666 SGTC_13 0199-0087 65 µM 2.34834763980811 0.00767753399022787 no 96 0.00942845610580004 37 4589825 SGTC_1331 1472-0049 76.2 µM 2.34446799339599 0.00776289856135125 no 97 0.00952712293068025 37 24051409 SGTC_3246 9135460 32.98 µM 2.32882487523326 0.00811562851838069 no 98 0.00993417252256615 23 41446951 SGTC_2452 5863136 48.41 µM 2.32147502997313 0.00828616635284112 no 99 0.010130610112539 40 2184096 SGTC_1932 st074806 40.9 µM 2.3186980043647 0.00835141601004265 no 100 0.0102057084079123 39 17251235 SGTC_2540 epiandrosterone 100 µM 2.31121077195143 0.00852959071533175 no 101 0.0104106078316414 42 441302 A steroid. SGTC_275 trichlorophene 5.69 µM 2.30359476967202 0.0087142430771052 no 102 0.0106227008659916 23 62616 SGTC_415 dibenzyl ketone 100 µM 2.29880440940402 0.00883217434286968 no 103 0.0107580241617075 34 7593 SGTC_265 mycophenolic acid 32.932 µM 2.29467195469823 0.0089350304509817 no 104 0.0108759656028015 25 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1509 1326-1131 80 µM 2.29444088132139 0.0089408126845185 no 105 0.0108825935968878 22 768313 SGTC_2552 juarezic acid 87.02 µM 2.26214849816384 0.00978181825265796 no 106 0.0118441150251973 20 1549512 SGTC_1708 st033234 31.827 µM 2.2565565969023 0.0099342658315459 no 107 0.0120178975177331 36 674664 SGTC_565 1418-0001 44.5 µM 2.23873098661488 0.010434160701105 no 108 0.0125867125386779 37 2862145 SGTC_322 k048-0136 19.3 µM 2.21444822338571 0.0111503356401309 no 109 0.0133989803549919 44 6823282 SGTC_3333 9141820 12.094 µM 2.21011103997811 0.0112826552992813 no 110 0.0135487284276708 42 1939433 SGTC_2708 st078559 56 µM 2.19450673412939 0.0117700662354597 no 111 0.0140995001808474 17 17250902 SGTC_749 1000-0129 128 µM 2.19203030882104 0.0118490757922968 no 112 0.0141886591037753 32 708470 SGTC_2437 5741531 144.16 µM 2.1707405576554 0.0125475095160567 no 113 0.0149753947646919 62 2262990 SGTC_1418 3966-3099 2.4 µM 2.15978183331984 0.0129207200766981 no 114 0.0153947813201805 50 740335 SGTC_2547 epiafzelechin trimethyl ether 100 µM 2.1553755335398 0.0130734652491293 no 115 0.0155662296779223 21 6708630 An antioxidant. SGTC_2069 5228469 200 µM 2.1433379923047 0.0134987294326272 no 116 0.0160429841169823 38 2835210 SGTC_1810 st050138 53 µM 2.14202938818391 0.0135456718201842 no 117 0.0160955586224988 44 3444541 SGTC_2789 5281112 71.43 µM 2.13243441350644 0.0138941875599592 no 118 0.0164855754255141 44 765948 SGTC_2235 salicylic acid 500 µM 2.13130301546813 0.0139357882523482 no 119 0.0165320934051645 28 338 A COX inhibitor and kinase inhibitor. SGTC_879 0831-1030 162 µM 2.12723085148175 0.01408640883577 no 120 0.0167004534652085 72 1549252 SGTC_1817 st052116 64.4 µM 2.12029790792482 0.0143460717363513 no 121 0.0169904649962986 30 4361398 SGTC_1860 st056228 74.6 µM 2.11551208967637 0.0145277128261029 no 122 0.0171931628152166 55 688679 SGTC_266 formosanin C 406 nM 2.10727612145463 0.0148449367088973 no 123 0.0175468259683164 74 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_16 erodoxin 22.806 µM 2.10444105437237 0.0149555042004035 no 124 0.0176699956953737 84 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2663 amphotericin b 100 µM 2.10311928166731 0.0150072947799747 no 125 0.0177276719346754 60 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2695 st077686 51.995 µM 2.10270602800713 0.0150235187610924 no 126 0.0177457374026248 35 2876092 SGTC_2140 5586273 200 µM 2.0902134441563 0.0155211324360164 no 127 0.0182993151940548 46 854421 SGTC_2570 licareol 100 µM 2.08649047330621 0.0156721379451574 no 128 0.0184671086342639 53 443158 SGTC_3117 9124945 49.47 µM 2.08145702180646 0.015878299982637 no 129 0.0186960470215393 27 17592065 SGTC_685 1278-0033 54.9 µM 2.07713529359368 0.0160571622030744 no 130 0.018894536967341 47 3590572 SGTC_2181 6316240 54.2555 µM 2.07419370486432 0.0161798902397253 no 131 0.0190306623240131 37 12779990 SGTC_301 4119-0100 24.5 µM 2.07123550996586 0.0163041207194339 no 132 0.0191683963223057 38 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1647 st011722 22.4 µM 2.05683294911672 0.0169206970669008 no 133 0.0198511487396241 47 2854783 SGTC_2700 st077718 96.8 µM 2.04788972661951 0.017313506226316 no 134 0.0202854028638508 42 904970 SGTC_2564 betulinic acid 100 µM 2.04715475028557 0.0173461318603563 no 135 0.0203214463507959 55 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1160 4092-0570 10.5 µM 2.04355676283838 0.0175066054273463 no 136 0.0204986771837979 53 4994975 SGTC_731 3966-0296 387 µM 2.04211316418613 0.0175713466282527 no 137 0.0205701536847322 34 660956 SGTC_465 cgp-37157 41 µM 2.04164650985945 0.0175923183789489 no 138 0.0205933041214464 27 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2019 4016004 108 µM 2.0398619431847 0.0176727151541991 no 139 0.0206820390758111 58 45595336 SGTC_3199 9111318 49.47 µM 2.03056744062538 0.0180965302006294 no 140 0.0211494467015959 41 8548020 SGTC_3296 9122258 64.045 µM 2.01923584696822 0.0186249256675915 no 141 0.0217313560764284 43 4730474 SGTC_2226 7298446 200 µM 2.01767254254727 0.0186988439622552 no 142 0.0218126881290632 35 3283010 SGTC_1376 2910-0861 41.3 µM 2.01206404484854 0.0189660907186227 no 143 0.0221065931124139 47 1112859 SGTC_1829 berberine 14.4 µM 2.00634837104062 0.0192417798922746 no 144 0.0224095462943617 62 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2014 4013930 200 µM 2.00616416795324 0.0192507210825662 no 145 0.0224193677392255 53 64556 SGTC_3151 9099821 49.47 µM 1.99941790557116 0.0195806251540336 no 146 0.02278157808829 60 17174189 SGTC_1579 chlormadinone acetate 49.4 µM 1.99684653627018 0.0197076272635895 no 147 0.0229209282539915 59 45114258 A steroidal progestin. SGTC_237 nikkomycin 200 µM 1.99025674401546 0.0200362991309554 no 148 0.0232813301836996 61 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1052 3253-3998 198 µM 1.98703970828602 0.0201984333851534 no 149 0.0234589983348439 43 5450317 SGTC_2186 6124449 200 µM 1.98441336201213 0.0203316212407832 no 150 0.0236048888269571 66 3834182 YLR033W RSC58 SGTC_2297 7971671 152.32 µM 1.98413293597749 0.0203458861552395 no 151 0.0236205111602308 53 909016 SGTC_35 0133-0054 64.071 µM 1.97709576691237 0.0207066453454088 no 152 0.0240154030931942 66 99677 SGTC_2776 terbinafine 19.92 µM 1.97384978564007 0.0208748670153954 no 153 0.0241994129590074 57 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1636 st007707 68.9 µM 1.97102191469923 0.0210223618635924 no 154 0.0243606846119019 42 403051 SGTC_2949 9072542 2.23 µM 1.96950469468815 0.0211018592149024 no 155 0.0244475820019207 63 16457352 SGTC_3285 9112818 20.8695 µM 1.96468819022242 0.0213559155603079 no 156 0.024725168825737 72 17017947 YPR165W RHO1 SGTC_2339 9000433 200 µM 1.96320395908582 0.0214347237519233 no 157 0.0248112397623847 45 2988954 SGTC_3189 9110682 49.47 µM 1.96138097880953 0.0215318547912459 no 158 0.0249172985934198 54 17122418 SGTC_1656 st012921 11 µM 1.9604448995958 0.0215818748365135 no 159 0.0249719061294667 44 6732821 SGTC_1990 st072050 59.8 µM 1.95532322041019 0.0218572970394756 no 160 0.0252724660682367 43 17233948 SGTC_2046 4110841 106 µM 1.95287483677143 0.0219900058734026 no 161 0.0254172140264212 67 44119630 YMR134W ERG29 SGTC_2566 crystal violet carbinol 226 nM 1.95084769045236 0.0221003967113998 no 162 0.0255375833942618 93 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1333 1482-0047 286 µM 1.9499318858108 0.0221504211979614 no 163 0.0255921190363121 51 3811116 SGTC_1419 3993-2473 62.6 µM 1.94929890932748 0.0221850524317716 no 164 0.0256298693839511 47 704026 SGTC_2416 tofa 880 nM 1.94417177675149 0.0224672541704281 no 165 0.0259373700042237 38 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_414 piperonyl butoxide 100 µM 1.94284804672226 0.0225406031254537 no 166 0.0260172603559679 51 5794 A potent inhibitor of cytochrome P450. SGTC_59 0330-0160 1.33 µM 1.93883498613294 0.0227642050388623 no 167 0.0262607172489323 49 4293482 SGTC_2211 7117706 200 µM 1.93250743606292 0.0231205627935304 no 168 0.0266484525666036 32 822771 SGTC_29 0299-0004 12.984 µM 1.93099384165776 0.0232064988174604 no 169 0.0267419069990601 30 16871 A napthoquinone isolated from Swertia calycina. SGTC_120 rhodamine 6G 52.259 µM 1.91398651936419 0.0241907309006009 no 170 0.0278109391265233 109 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1312 1218-2183 165 µM 1.89472210222988 0.0253476968593545 no 171 0.0290646139945691 58 6744073 SGTC_711 k292-0785 179 µM 1.8939308889159 0.0253961892428166 no 172 0.0291170919248775 67 4146315 SGTC_346 4513-0042 7.16 µM 1.88940307994321 0.0256751895179089 no 173 0.0294189192583154 65 2827372 SGTC_2627 acetyl isogambogic acid 100 µM 1.87102662199397 0.0268340058710446 no 174 0.0306706955562241 68 6857789 A caspase activator and apoptosis inducer. SGTC_2906 7926292 26.41 µM 1.8697926602128 0.0269133594252673 no 175 0.0307563080086672 50 2966319 SGTC_173 1273-0061 2.693 µM 1.86835384208124 0.027006134156872 no 176 0.0308563831769454 92 2847414 YPL266W DIM1 SGTC_3073 9114972 49.47 µM 1.8634037242359 0.0273273580412042 no 177 0.0312027432287224 46 41905075 SGTC_1411 3909-8223 150 µM 1.86279931530712 0.0273667968624513 no 178 0.0312452532086924 74 X1411 SGTC_508 roscovitine 141 µM 1.86085122304291 0.0274942367465434 no 179 0.031382594779016 50 160355 A CDKinase inhibitor. SGTC_2273 7815444 169.05 µM 1.85784941137631 0.0276915769725066 no 180 0.0315952010288334 76 2824616 SGTC_2665 lovastatin 100 µM 1.85671107647883 0.0277667195799792 no 181 0.0316761353927533 49 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_488 nitrendipine 139 µM 1.85514307838765 0.0278705028069192 no 182 0.0317878987821994 42 4507 Dihydropyridine L-type calcium channel blocker. SGTC_655 k060-0012 42 µM 1.84784349798149 0.0283579130165512 no 183 0.032312493136869 75 5994525 SGTC_1297 1068-0111 14.1 µM 1.83033642108103 0.0295558656835706 no 184 0.0335998242144064 57 767057 SGTC_1739 st037196 92.5 µM 1.82796725886431 0.0297211609512901 no 185 0.0337772327999364 48 612214 SGTC_772 k072-0172 35.3 µM 1.82551377827596 0.0298931468112474 no 186 0.0339617669488895 45 5861980 SGTC_1458 k015-0034 6.33 µM 1.81786635478443 0.0304345254944635 no 187 0.0345422809030151 46 3598957 SGTC_736 0958-0254 92.6 µM 1.81371880997019 0.0307315211124572 no 188 0.0348605138299442 59 6812352 SGTC_2600 tangeritin 87.95 µM 1.81370381325792 0.0307325993290702 no 189 0.0348616688504543 71 68077 A bioactive flavone. SGTC_1012 4112-3522 18 µM 1.81261911127919 0.0308106691044847 no 190 0.0349452940486981 56 3112398 SGTC_2106 5357045 167.29 µM 1.81080479760125 0.0309416184966993 no 191 0.0350855367094395 64 668842 SGTC_2715 st079500 56.4 µM 1.81029116722966 0.0309787736821793 no 192 0.0351253230391573 67 28246688 SGTC_1406 3909-7906 11.9 µM 1.80971792688906 0.0310202845460882 no 193 0.0351697705223435 59 X1406 SGTC_129 0088-0017 176.636 µM 1.8031873554046 0.0314964491943937 no 194 0.0356793978107487 52 182446 SGTC_1400 3771-8998 51.5 µM 1.79864184911322 0.0318314301121974 no 195 0.0360376764807353 28 670767 SGTC_1972 st070201 17.4 µM 1.79746538944145 0.031918607072382 no 196 0.0361308839737965 55 2829099 SGTC_2687 chenodiol 100 µM 1.79618053328135 0.0320140415146129 no 197 0.0362329048331913 70 5702181 A cholesterol synthesis inhibitor. SGTC_3018 9082602 49.47 µM 1.77855532759398 0.0333471265526671 no 198 0.0376563467627814 69 17332089 SGTC_207 4185-0010 4.486 µM 1.7744315166037 0.0336655431633622 no 199 0.0379959002791556 93 3761753 SGTC_1030 k029-0042 36.7 µM 1.77334720790423 0.0337496813345435 no 200 0.0380855955240783 61 6080581 SGTC_2595 hexamethylquercetagetin 100 µM 1.77268100981358 0.0338014614900827 no 201 0.0381407897889736 78 386331 SGTC_1659 st012954 42.1 µM 1.77229160762025 0.0338317579773649 no 202 0.0381730818156789 55 24207262 SGTC_2365 9042475 200 µM 1.77120912571319 0.0339160952230251 no 203 0.038262966146986 73 6464479 SGTC_1618 st003135 44.5 µM 1.7613010556946 0.0346961058759431 no 204 0.0390937307388234 67 1270615 SGTC_2017 5132927 60.65 µM 1.75677920517753 0.0350569519407276 no 205 0.0394777254410568 45 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1482 3346-2049 8.48 µM 1.75501046849736 0.0351989334170461 no 206 0.0396287585730682 68 3826804 SGTC_1982 st072467 71.9 µM 1.75467435615917 0.0352259673700044 no 207 0.0396575124030303 84 3163533 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.74841633983113 0.035732426192012 no 208 0.040195980268947 57 6710655 SGTC_1008 4106-0037 6 µM 1.74495825709335 0.0360148375612897 no 209 0.0404960676858331 79 2905394 SGTC_842 0271-0008 11.1 µM 1.74151743861546 0.0362976508768883 no 210 0.0407964596073668 82 1221709 SGTC_2312 7706453 155.7 µM 1.7361727526132 0.0367405528368266 no 211 0.0412666467624393 88 976098 SGTC_1815 st051655 58.2 µM 1.73610225255417 0.0367464244201087 no 212 0.0412728780831371 92 5984156 SGTC_1101 ebselen 5.29 µM 1.73482687984977 0.0368527761604587 no 213 0.0413857367956808 89 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1609 st001574 46.4 µM 1.72917511715712 0.0373271025569197 no 214 0.0418888791574812 72 3960012 SGTC_2040 5100729 123 µM 1.72710053708924 0.0375024589817659 no 215 0.0420748045882564 73 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_475 α-linolenic acid 10 µM 1.72309277651997 0.0378431248872107 no 216 0.0424358744470701 85 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1885 st057546 99.9 µM 1.71934841099864 0.038163679620443 no 217 0.0427754749408717 66 702008 SGTC_2551 apiole 73.87 µM 1.71708657215436 0.0383583859363088 no 218 0.0429816776310844 55 10659 A possible DNA adduct former. SGTC_2676 harmalol 100 µM 1.71596664169463 0.0384550924683258 no 219 0.0430840740402457 70 5459187 A monoamine oxidase inhibitor SGTC_2620 irigenin 100 µM 1.71085220023051 0.0388992559632562 no 220 0.0435542002224323 95 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3249 9135183 49.47 µM 1.71007494889582 0.0389671206004635 no 221 0.0436260072581281 65 4902779 SGTC_2526 patulin 37.61 µM 1.70872216145794 0.039085467286293 no 222 0.0437512135127749 89 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1912 st060209 90.8 µM 1.70786215767407 0.0391608555144826 no 223 0.0438309611619476 86 688787 SGTC_1402 3909-7673 35.9 µM 1.69878554081177 0.0399637532129168 no 224 0.0446797994846974 57 5328014 SGTC_2981 9013952 38.96 µM 1.69770250863913 0.040060442939011 no 225 0.0447819620302414 70 2996344 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.69631095418509 0.0401849554927271 no 226 0.044913503532556 83 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2310 7668677 200 µM 1.69479987507785 0.0403205186392813 no 227 0.0450566956028944 106 2197143 SGTC_1469 k284-2957 126 µM 1.69131564396256 0.0406345145171179 no 228 0.0453882668779816 82 23884841 SGTC_683 panaxydol 45 µM 1.68836785688613 0.0409017137356485 no 229 0.0456703183536574 51 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1354 1498-1681 81 µM 1.68546982393475 0.0411657907191626 no 230 0.0459489810338584 82 5754243 SGTC_1737 st035557 69.7 µM 1.68428411933786 0.0412742332277191 no 231 0.046063386498212 82 5716916 SGTC_2006 4011487 200 µM 1.6644082518292 0.0431267628507716 no 232 0.0480154360726435 102 45595294 SGTC_3299 9121982 43.1275 µM 1.66175023487985 0.0433795173421141 no 233 0.048281432085062 67 17594604 YPL160W CDC60 SGTC_2954 9074818 52.69 µM 1.66064278962781 0.0434851781773883 no 234 0.0483926048794853 83 16648742 SGTC_1889 st059080 5.18 µM 1.65729277801061 0.0438060664269407 no 235 0.0487301483572036 65 176925 Isolated from Daphnopsis sellowiana. SGTC_2461 5755302 26.15 µM 1.65285807279714 0.0442337896137128 no 236 0.0491798759204685 81 2788904 SGTC_2257 7960413 200 µM 1.64965663302644 0.0445446528193307 no 237 0.0495065923796129 91 2974689 YIL048W NEO1 SGTC_1630 st005209 31.3 µM 1.64681452336723 0.0448220971851225 no 238 0.0497980876198368 72 3367314 SGTC_860 0443-0016 25.1 µM 1.64543437483747 0.0449573271180292 no 239 0.0499401327967307 102 5337942 SGTC_3324 9138759 60.749 µM 1.63870420724918 0.0456214758207762 no 240 0.0506374387097661 68 45595710 SGTC_1786 berberine 21.6 µM 1.63806408646741 0.0456850531024217 no 241 0.0507041628673012 98 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_90 0870-0863 4.608 µM 1.63513106989748 0.0459772738695958 no 242 0.0510107870908752 90 1738164 SGTC_1637 st007924 17.4 µM 1.63073566739217 0.0464180038060029 no 243 0.0514730535626453 64 683336 SGTC_3217 9129673 49.47 µM 1.62016234044908 0.0474920957554829 no 244 0.0525987043964657 85 17248312 SGTC_1399 3562-5772 25 µM 1.61866582848771 0.0476457148139749 no 245 0.0527595915082283 83 23847490 SGTC_1492 4158-0558 28.5 µM 1.61641803058755 0.0478772019652807 no 246 0.0530019813060457 65 3967268 SGTC_3338 9144300 39.5675 µM 1.61464722207563 0.0480602001877129 no 247 0.0531935564927521 56 4901274 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.61279379935003 0.0482523350141262 no 248 0.0533946568521013 65 1241132 A phosphatase inhibitor. SGTC_3270 9137563 49.47 µM 1.61120492482652 0.0484175342383186 no 249 0.0535675323830001 64 17015724 SGTC_217 ketoconazole 989 nM 1.6080201310469 0.0487500270194843 no 250 0.0539153849432715 82 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2097 5376186 200 µM 1.60672380303888 0.0488858853042575 no 251 0.0540574848238868 88 742755 SGTC_73 0327-0325 16.231 µM 1.60653485354939 0.0489057129020329 no 252 0.0540782216736179 46 53298 SGTC_2 0422-0095 29 µM 1.60612829447357 0.0489483973603636 no 253 0.0541228621130189 78 6790840 SGTC_2980 9014342 25.29 µM 1.60488818026519 0.0490787802953799 no 254 0.0542592075953222 116 2996599 SGTC_1718 roemerine 11.9335 µM 1.60238867715997 0.0493424156562087 no 255 0.0545348435538061 97 235224 An aporphine alkaloid with mutagenic activity. SGTC_538 2922-0838 53.3 µM 1.58680156563632 0.051012070870777 no 256 0.0562787970703584 104 777039 SGTC_3323 9138564 53.9225 µM 1.5865168936291 0.0510429773125035 no 257 0.0563110514998408 96 43912313 YNL103W MET4 SGTC_1705 st027868 56.3335 µM 1.58549375044921 0.0511541815928719 no 258 0.0564270978647894 74 292948 SGTC_1254 0550-0035 264 µM 1.58548355016781 0.0511552912197674 no 259 0.0564282557435133 100 15121435 SGTC_2582 agaric acid 100 µM 1.58024169778865 0.051728059237602 no 260 0.0570257629647435 120 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1539 benzyladenosine 56 µM 1.57751886555667 0.0520275836837332 no 261 0.0573380923445139 88 92208 A nucleotide analog. SGTC_1053 3366-3204 134 µM 1.57490615735767 0.0523162877878098 no 262 0.0576390535993137 103 3632071 YPR165W RHO1 SGTC_327 1273-0057 3.96 µM 1.56888089059889 0.0529869290619993 no 263 0.0583378476740444 82 3108138 SGTC_1941 st076221 61.8 µM 1.56854920283123 0.0530240445946691 no 264 0.0583765083165153 99 2828568 SGTC_2610 ononetin 44.17 µM 1.5639432972194 0.0535415746119913 no 265 0.0589154426219298 93 259632 SGTC_1325 1431-0015 227 µM 1.55859913838116 0.054147063089109 no 266 0.0595456435533088 82 1103340 SGTC_3326 9140064 16.379 µM 1.55264167080382 0.0548284126987942 no 267 0.0602543822535349 87 1868434 SGTC_3144 9087057 49.47 µM 1.54583327686966 0.0556153603213744 no 268 0.0610724190572232 84 17249618 SGTC_1224 0823-0416 294 µM 1.54545077214988 0.0556598352364921 no 269 0.0611186337528087 84 3598164 SGTC_1697 st025554 27.742 µM 1.54041026752695 0.0562485348292776 no 270 0.0617301901102349 86 1269519 SGTC_1529 apigenin 74 µM 1.53648693018276 0.0567101449214635 no 271 0.0622095004275123 95 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2182 6325192 200 µM 1.53428919990432 0.0569700254009375 no 272 0.0624792607580202 82 736248 SGTC_1530 rhein 70.4 µM 1.53001965257201 0.0574775767421688 no 273 0.0630059322434121 93 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2967 9089538 49.85 µM 1.52776895580777 0.057746561168992 no 274 0.0632849562916945 114 728216 SGTC_410 α-linolenic acid 100 µM 1.52204636086544 0.058434935898108 no 275 0.0639987323253265 98 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2243 6634756 200 µM 1.51020051058858 0.0598803449616593 no 276 0.0654961342288879 62 885676 SGTC_2681 menadione 3.18 µM 1.50808564548395 0.0601413184245062 no 277 0.0657663042852234 102 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.50712776961179 0.060259812516317 no 278 0.0658889550152672 120 6708760 SGTC_1407 3909-7909 12.3 µM 1.50379307971011 0.0606737564771566 no 279 0.0663173268021634 82 4411780 SGTC_3149 9097855 49.47 µM 1.49726121410672 0.0614910161156856 no 280 0.0671626514153575 82 25236625 YMR079W SEC14 SGTC_2519 cryptotanshinone 88.04 µM 1.49544891842233 0.0617192855027566 no 281 0.0673986609130603 122 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1944 st076371 56.9 µM 1.49170606190559 0.062192814067268 no 282 0.0678881096342985 95 24208455 SGTC_1638 st008370 60.6 µM 1.48789065647556 0.0626784332601429 no 283 0.0683898660838228 110 24207134 SGTC_795 0685-0265 78 µM 1.48749599637942 0.0627288332095845 no 284 0.0684419299226967 124 302754 SGTC_1712 st032288 53.4 µM 1.48146130827565 0.0635034309871545 no 285 0.0692418439928567 143 2883011 SGTC_3175 9106517 49.47 µM 1.47957894436277 0.0637465636671966 no 286 0.0694928245280202 95 41468073 SGTC_1276 0871-0068 94.2 µM 1.47893772646212 0.0638295507541028 no 287 0.0695784795805525 118 3414906 SGTC_418 lividomycin a 100 µM 1.47820606394022 0.0639243458951662 no 288 0.0696763156620639 94 72394 An antibiotic. SGTC_2803 7707263 71.43 µM 1.4766719037875 0.0641234690931508 no 289 0.0698818035280263 82 2199229 SGTC_257 daunorubicin 18.5 µM 1.4740641765747 0.0644630397232804 no 290 0.0702321563447306 101 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2241 6772625 37.8075 µM 1.47318099523048 0.0645783611937635 no 291 0.0703511190799196 105 2285411 SGTC_293 4049-0273 38.5 µM 1.46381056907392 0.0658117959302092 no 292 0.0716228569196844 100 1380311 SGTC_2689 tacrolimus 100 µM 1.46252654842035 0.0659822253988104 no 293 0.071798487356922 99 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2571 chrysanthemic acid 100 µM 1.46206578606435 0.0660434661999017 no 294 0.0718615916529343 103 2743 An insecticide. SGTC_864 0469-0573 172 µM 1.45616450853733 0.0668317154401222 no 295 0.0726735741097013 101 689425 SGTC_1251 0490-5699 265 µM 1.45430786065388 0.0670812122906608 no 296 0.0729304860492278 109 3883818 SGTC_971 1315-0384 26.7 µM 1.45393059224158 0.0671319976660134 no 297 0.0729827751010063 108 6769120 SGTC_948 3448-0295 75.3 µM 1.4538968335664 0.0671365434841568 no 298 0.0729874554203866 106 678569 SGTC_1142 3253-1408 9.78 µM 1.45376196780557 0.067154706382867 no 299 0.0730061555681189 97 256655 SGTC_244 nsc-207895 1.295 µM 1.45211094025916 0.0673773647948381 no 300 0.073235380223774 49 42640 SGTC_1809 st050081 57.6 µM 1.44740419336877 0.0680152515644851 no 301 0.073891875993134 102 5036894 SGTC_690 glyoxal 20.3 µM 1.44712763169332 0.0680528774153409 no 302 0.0739305901759233 128 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1285 0929-0069 65.5 µM 1.44691030846784 0.0680824552267234 no 303 0.0739610228027179 83 1206237 SGTC_39 0986-0283 58.349 µM 1.44260705648433 0.0686701761960647 no 304 0.0745655972221507 92 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_965 1291-5240 308 µM 1.44061419515815 0.068943675320848 no 305 0.074846853924646 104 2834598 SGTC_775 4577-0580 57.3 µM 1.4397121535068 0.0690677466967344 no 306 0.0749744267287892 103 2006902 SGTC_2657 nystatin 74.44 µM 1.43664935665281 0.0694903035413604 no 307 0.0754088258407414 94 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1154 4088-0362 150 µM 1.43483682682177 0.0697413041235534 no 308 0.075666800495943 103 6618304 SGTC_579 4491-1009 110 µM 1.43417684376561 0.0698328722244912 no 309 0.0757609016883258 135 1271041 SGTC_891 0929-0073 133 µM 1.43198779271414 0.0701372504729716 no 310 0.0760736574684645 114 5603632 SGTC_3252 9135871 49.47 µM 1.43013130539562 0.0703961859948373 no 311 0.0763396683839373 96 17682838 SGTC_778 3456-2434 196 µM 1.42757024366938 0.0707545983220547 no 312 0.0767077967403027 99 5539063 SGTC_2350 9023895 38.85 µM 1.42313255660846 0.0713789558101531 no 313 0.0773488660598024 111 2997209 SGTC_2355 9061122 103.12 µM 1.42227758386347 0.0714997300239911 no 314 0.0774728418406496 113 5302957 SGTC_124 0136-0217 7.121 µM 1.41821981547964 0.0720750732994048 no 315 0.0780632992003052 145 3976905 SGTC_2356 9061756 188.97 µM 1.41640356686901 0.0723337427173496 no 316 0.0783286901021514 100 20104043 SGTC_2707 st078556 66.6 µM 1.41572303770452 0.0724308464074096 no 317 0.0784283052785799 89 17250899 SGTC_1121 fusaric acid 630.51 nM 1.4136033438167 0.0727339424012024 no 318 0.0787391994742054 98 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_893 0958-0369 48.9 µM 1.41203545698241 0.0729587594208354 no 319 0.0789697606578547 116 6819948 SGTC_1503 4585-0012 61.3 µM 1.40653520526467 0.0737516396937268 no 320 0.0797826290966559 93 2922052 SGTC_1929 genistein trimethyl ether 50.5 µM 1.40629359022445 0.0737866197587215 no 321 0.0798184813513233 106 136420 SGTC_1770 st043884 66.3 µM 1.40183817165443 0.0744339326870254 no 322 0.0804817884389313 138 670149 SGTC_737 1950-0117 57.9 µM 1.40168198424219 0.074456703040943 no 323 0.0805051163946217 117 5393513 SGTC_493 zm226600 134 µM 1.40082733968533 0.0745813947005527 no 324 0.0806328554868624 115 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2840 9008771 71.43 µM 1.39919422577214 0.0748201073282313 no 325 0.0808773738290199 64 2992978 SGTC_3106 9121286 49.47 µM 1.39907295019857 0.0748378574307781 no 326 0.080895554145422 95 15943471 SGTC_784 4579-0127 173 µM 1.39388838406021 0.0755996875975789 no 327 0.0816756562738424 113 1948547 SGTC_2985 9022375 71.43 µM 1.3930744451243 0.0757198240974426 no 328 0.0817986399475239 108 4939335 SGTC_2875 9039966 71.43 µM 1.3895161883412 0.0762467269793269 no 329 0.0823379208917752 96 6463691 SGTC_261 5-fluorouridine 15.376 µM 1.3889024931101 0.0763378837706167 no 330 0.0824312011624031 95 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3308 9128332 17.569 µM 1.38876572192108 0.0763582107248374 no 331 0.0824520009079832 111 17332805 YDL196W YDL196W SGTC_2164 5685496 200 µM 1.38648697572391 0.0766974845340106 no 332 0.0827991272744799 92 759046 SGTC_738 1315-0003 72.4 µM 1.38635415087743 0.0767172956178529 no 333 0.082819394636194 127 6251474 SGTC_2766 oltipraz 83.91 µM 1.3813600680321 0.0774649997117715 no 334 0.0835841387053338 118 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1326 1431-2094 10.8 µM 1.38129337559902 0.0774750220825786 no 335 0.0835943871013816 126 616278 SGTC_535 2293-4129 48.2 µM 1.38047688149603 0.0775978025969726 no 336 0.0837199314802997 142 396118 YIL048W NEO1 SGTC_1983 st071813 46.9 µM 1.3774551019484 0.0780534888388394 no 337 0.0841857934545468 113 11838595 SGTC_106 0092-0003 11.579 µM 1.3718868112434 0.0788985036625658 no 338 0.0850493383661687 101 1072148 SGTC_2299 7976368 114.88 µM 1.36832051207362 0.0794433360173243 no 339 0.0856058864660136 99 2979718 SGTC_2420 aureobasidin a 50 nM 1.36721123016133 0.0796133830301024 no 340 0.0857795531636548 97 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1218 1348-1416 30.7 µM 1.36544811591548 0.0798842255617387 no 341 0.0860561248839641 111 6787668 SGTC_626 0214-0009 33 µM 1.36160260940307 0.0804773733311039 no 342 0.0866616656548088 117 3437874 SGTC_2430 5571206 200 µM 1.35863351290903 0.0809376113738306 no 343 0.0871313750444709 130 1731771 SGTC_1210 3013-0140 750 nM 1.35403676895251 0.0816540653066932 no 344 0.0878623236827976 113 905973 SGTC_2205 7238770 200 µM 1.35299507778579 0.0818170870659091 no 345 0.0880286014390146 105 279867 SGTC_3240 9133527 49.47 µM 1.35142572036925 0.0820631501260983 no 346 0.0882795496521955 106 17617455 SGTC_2647 atorvastatin 60.16 µM 1.34564579736448 0.082974206269223 no 347 0.089208387241441 97 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_899 1083-0020 478 µM 1.34541246103781 0.0830111448658137 no 348 0.0892460366793493 123 767123 SGTC_443 clozapine 122 µM 1.34506713174321 0.0830658353441794 no 349 0.0893017781750279 102 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3080 9117754 49.47 µM 1.34080783636538 0.0837426182990204 no 350 0.0899914256439501 129 9550191 SGTC_211 3455-0679 143.504 µM 1.33781398414037 0.084220801304362 no 351 0.0904785410716144 94 748649 SGTC_291 SEC14.278 35.5 µM 1.33209146052343 0.0851405100801575 no 352 0.0914150680483337 113 1068044 SGTC_285 1486-1325 46 µM 1.33131639650769 0.0852656528098063 no 353 0.091542462658574 130 22310230 SGTC_657 3534-0529 86.7 µM 1.33022031139891 0.085442863153106 no 354 0.0917228469302388 122 1049549 SGTC_3203 9113543 49.47 µM 1.32937964427492 0.0855789654219949 no 355 0.0918613750409905 131 17018012 SGTC_1846 st056244 14.8 µM 1.32707013341412 0.0859537059903925 no 356 0.0922427419744006 101 5393182 SGTC_3176 9106582 49.47 µM 1.32701881501313 0.0859620468230384 no 357 0.0922512294136076 58 17018027 SGTC_1835 st008666 49.2 µM 1.32681534457373 0.0859951230447321 no 358 0.0922848866382674 93 690455 SGTC_2619 obliquin 87.91 µM 1.32512617906375 0.0862700821228469 no 359 0.0925646522722623 130 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3345 9148410 3.559 µM 1.32480029979075 0.0863232036955168 no 360 0.092618697684568 118 4903596 SGTC_1768 st044301 37.178 µM 1.32394789106586 0.086462270493001 no 361 0.092760175688131 146 3931349 SGTC_3248 9135562 49.47 µM 1.32226768067796 0.0867368799280859 no 362 0.0930395154272694 115 17650701 SGTC_2890 9046729 58.44 µM 1.32150876450335 0.0868611287812373 no 363 0.093165891046544 131 903329 SGTC_2757 clomiphene 4.22 µM 1.31913610347396 0.0872504357617634 no 364 0.0935618075652818 157 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1496 4469-0713 57.4 µM 1.31808051073251 0.0874240558921946 no 365 0.0937383489451416 118 746691 SGTC_477 mead ethanolamide 10 µM 1.31529683548645 0.0878831413680893 no 366 0.0942050806278179 61 16061185 SGTC_1604 st002052 72.4 µM 1.3135943775831 0.0881647964808036 no 367 0.0944913709017019 110 6254834 YHR062C RPP1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.31054696372325 0.0886706408506691 no 368 0.0950054337951219 112 5355888 SGTC_338 4055-0136 114 µM 1.30664177784226 0.0893220237822158 no 369 0.0956672004229049 104 2900563 SGTC_1190 1486-1332 13 µM 1.3049521200147 0.0896049585735253 no 370 0.0959545760120782 129 4150046 SGTC_1036 k216-0215 33.5 µM 1.30194366987574 0.0901103750984341 no 371 0.0964678212841475 110 622330 SGTC_421 streptovitacin 30 mM 1.29462356184418 0.0913489868717718 no 372 0.0977250601122357 122 91467 include heat shock SGTC_2323 6148992 148.28 µM 1.29405445472842 0.0914458098332744 no 373 0.0978233060015442 120 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2911 7942208 15.64 µM 1.29302496372236 0.0916211517494737 no 374 0.0980012126199735 100 1243384 SGTC_2047 4141938 200 µM 1.2880288034726 0.0924756321707012 no 375 0.0988679684289948 124 3807862 SGTC_2783 7738165 71.43 µM 1.28781232260306 0.0925127891624698 no 376 0.0989056508598544 115 17201110 SGTC_720 r052-1644 49.9 µM 1.28607600719063 0.0928112117245266 no 377 0.0992082683125087 137 1422863 YOR257W CDC31 SGTC_1426 4048-4480 71.7 µM 1.28413091768395 0.0931463612068207 no 378 0.0995480758491963 117 14224343 SGTC_2092 5303694 80.6725 µM 1.28411274772202 0.0931494962008722 no 379 0.0995512541503103 124 1963699 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.27665481470741 0.0944428607994991 no 380 0.100862070269539 137 688788 SGTC_3214 9129694 49.47 µM 1.27257964621605 0.0951551525023386 no 381 0.101583622472755 146 17158655 SGTC_2202 7226349 200 µM 1.27169507736922 0.09531028600061 no 382 0.10174074015624 106 844334 SGTC_3152 9099253 49.47 µM 1.27115157002606 0.0954056972846172 no 383 0.101837365982462 163 25236131 SGTC_2767 sibutramine 71.45 µM 1.26750655912964 0.0960473868020728 no 384 0.102487109893287 109 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2405 ticlatone 3.52 µM 1.2673515911085 0.09607473845739 no 385 0.102514800465933 106 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_342 k048-0088 23.3 µM 1.26519889461403 0.0964552791072857 no 386 0.102900019313003 131 6820570 SGTC_1231 0242-0792 125 µM 1.2650459878666 0.0964823511033249 no 387 0.102927421485908 127 3707635 SGTC_178 4092-0806 87.505 µM 1.26070498056668 0.0972532530291982 no 388 0.103707579425985 149 2169044 SGTC_1103 duloxetine 36.1 µM 1.25964096695881 0.0974428946818877 no 389 0.103899454977331 142 60835 A selective serotonin reuptake inhibitor. SGTC_2759 disulfiram 3.38 µM 1.2572013643619 0.097878734471681 no 390 0.104340364694422 147 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_844 0330-0132 15.3 µM 1.25540148545208 0.0982012011060731 no 391 0.10466652519036 130 2828079 SGTC_2432 5630864 12.22 µM 1.25303376472912 0.0986265867082366 no 392 0.105096709492384 127 5714970 SGTC_1253 0550-0034 176 µM 1.2522748954896 0.098763210462163 no 393 0.105234856657067 134 5969915 SGTC_674 0498-0004 451 µM 1.24993838965024 0.0991847351732693 no 394 0.10566102717421 158 4231473 SGTC_856 0433-0016 11.3 µM 1.24885296076868 0.0993810023368185 no 395 0.10585942955369 120 3911780 SGTC_1078 idebenone 36.1 µM 1.24871644680344 0.0994057068662672 no 396 0.105884401592914 163 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2162 5663267 200 µM 1.2456220978486 0.0999668867210146 no 397 0.106451582833309 136 6456493 SGTC_24 0417-1663 219 µM 1.24251974033186 0.100531838004481 no 398 0.10702243087711 120 4329390 SGTC_1522 st012842 45.6 µM 1.24206852867027 0.10061419903089 no 399 0.107105639473016 137 3491067 YOR116C RPO31 SGTC_1249 0481-0015 10.2 µM 1.24056926257578 0.100888218061642 no 400 0.107382456355676 148 4227577 SGTC_1534 6-azauridine 81.6 µM 1.23837497898979 0.101290244916189 no 401 0.107788526897566 149 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1395 3486-0190 4.35 µM 1.23579444452751 0.101764530912023 no 402 0.108267490273141 140 6748079 SGTC_2397 5161689 200 µM 1.23374545333564 0.102142272528875 no 403 0.108648885429963 119 2259942 SGTC_1871 st057448 67.3 µM 1.23108869890883 0.102633575699635 no 404 0.109144845892604 143 691747 SGTC_1650 st011916 45.8 µM 1.22798631397143 0.103209458956657 no 405 0.109726052826242 134 242528 SGTC_1602 st001878 87.6 µM 1.22476187440781 0.103810481642605 no 406 0.110332476826062 155 595405 YLR310C CDC25 SGTC_2043 5101342 149 µM 1.22428955603314 0.103898732649814 no 407 0.110421507693845 144 678451 SGTC_1443 4112-3303 14 µM 1.22197088834466 0.104332756712646 no 408 0.110859318047985 149 704433 SGTC_1424 4048-1941 275 µM 1.21777862434206 0.105120826055425 no 409 0.111654054708685 133 X1424 SGTC_116 0155-0182 31.788 µM 1.21744012374322 0.105184645468361 no 410 0.11171840239873 129 771486 SGTC_2412 st077135 33.4 µM 1.21528259818211 0.10559207477208 no 411 0.112129163321997 141 13258915 SGTC_3347 9188721 44.724 µM 1.2151754394415 0.105612340442952 no 412 0.112149592863681 155 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1838 st055369 84.5 µM 1.20843761583945 0.106892239077147 no 413 0.113439489112426 126 676036 SGTC_2052 5265182 7.135 µM 1.20646898143514 0.107268299338572 no 414 0.113818356101863 137 1239884 SGTC_988 1497-1057 103 µM 1.20643673321037 0.107274467517039 no 415 0.113824569824745 144 3533044 SGTC_3048 9093155 49.47 µM 1.20327700052542 0.107880076104026 no 416 0.114434573101879 123 25236002 SGTC_789 1309-1135 70.6 µM 1.20073824710207 0.108368446026059 no 417 0.114926376423483 131 3092424 SGTC_1427 4048-4900 550 nM 1.19630742760067 0.10922459257722 no 418 0.115788305649542 147 24132586 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.19538116053647 0.109404183328397 no 419 0.115969071453681 149 5282362 SGTC_1547 harmine 94.2 µM 1.194886735911 0.10950013240395 no 420 0.116065642947997 157 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_759 3486-0358 89.3 µM 1.19210694302178 0.110040709905087 no 421 0.116609657476969 155 875103 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.19101162661168 0.11025423761229 no 422 0.116824510307088 130 5379071 SGTC_2588 indole-3-carbinol 100 µM 1.19041574657633 0.110370526853896 no 423 0.116941513508287 140 3712 Induces cell cycle arrest. SGTC_283 0987-0079 11.7 µM 1.19015202788286 0.110422021061704 no 424 0.116993322130216 121 411556 SGTC_2507 purpurin 79.67 µM 1.18732393344322 0.110975323186525 no 425 0.117549935590632 146 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1526 st051518 75 µM 1.18631008448011 0.111174160278042 no 426 0.117749932797222 132 673993 SGTC_2464 5717415 7.67 µM 1.18621944056978 0.111191949869033 no 427 0.117767825414418 140 5285744 SGTC_2399 5884133 200 µM 1.18455491393752 0.111518988934542 no 428 0.118096736083256 149 722445 SGTC_2075 5212009 200 µM 1.18317050006627 0.111791516500682 no 429 0.118370790907743 145 780898 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.1814471885035 0.11213142257277 no 430 0.118712560724595 159 688801 SGTC_550 4123-0385 25.7 µM 1.18037154361873 0.112343956936865 no 431 0.118926237328199 141 5731123 SGTC_1309 pyrazolanthrone 13.4 µM 1.18024357695984 0.112369260740585 no 432 0.118951675942082 167 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1876 myriocin 605 nM 1.1798122896022 0.112454572402392 no 433 0.119037440264652 155 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2666 tannic acid 100 µM 1.17672957635024 0.113065702232993 no 434 0.119651729471976 169 16134267 A thiamine antagonist. SGTC_826 1683-5028 118 µM 1.17529965101221 0.113349979776862 no 435 0.119937427047855 133 722377 SGTC_849 0386-0493 241 µM 1.17489688620109 0.113430143726571 no 436 0.120017985762682 155 726119 SGTC_1886 st057356 49.9 µM 1.1690075380089 0.114606945524331 no 437 0.12120029716837 132 24207747 SGTC_1423 4048-0112 5.59 µM 1.16680209041362 0.115049863582558 no 438 0.121645151316475 153 X1423 SGTC_2743 auranofin 4.32 µM 1.16626138725275 0.115158638061559 no 439 0.121754389838249 110 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_646 4092-0839 27.3 µM 1.16610115909049 0.115190885563163 no 440 0.121786774046353 160 877796 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.16291300421809 0.115833868376361 no 441 0.122432400353513 170 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.16242288730543 0.115932940080252 no 442 0.122531865475924 152 91467 include heat shock SGTC_3253 9135987 49.47 µM 1.16228047396315 0.115961738636656 no 443 0.122560777698803 160 4182430 SGTC_60 0986-0278 202 µM 1.16077588416696 0.116266304243061 no 444 0.122866526307382 142 3110598 SGTC_1421 4029-0249 71.4 µM 1.15650577590538 0.117133768147764 no 445 0.123737169203978 168 2894095 SGTC_3343 9148379 18.9835 µM 1.15373883518614 0.117698309095826 no 446 0.124303628574891 137 1955036 SGTC_3265 9137266 49.47 µM 1.15358874662909 0.117728986742245 no 447 0.124334407090336 109 17224265 SGTC_2115 tiliquinol 12.7705 µM 1.14954365354383 0.118557923862151 no 448 0.125165938584457 155 71208 A bioactive hydroxyquinoline. SGTC_1327 1436-0082 2.18 µM 1.14878853467651 0.118713121656313 no 449 0.125321594094349 153 15992205 SGTC_925 2064-1272 59.6 µM 1.14576922835313 0.119335106652072 no 450 0.125945325328244 156 6815817 SGTC_2816 7982706 58.44 µM 1.14473625039315 0.119548429866333 no 451 0.126159215078188 162 2981853 SGTC_1133 3473-0247 50 µM 1.13916123396217 0.120704385933902 no 452 0.127317955602396 176 711311 SGTC_1669 st015249 58.4 µM 1.13797648561371 0.120951048841218 no 453 0.127565150634012 141 722793 SGTC_2469 5655019 90.81 µM 1.13710578355163 0.121132553734548 no 454 0.127747033232155 146 2788239 SGTC_2340 7987427 183.45 µM 1.13682191154119 0.121191770546799 no 455 0.127806370735579 147 2239331 SGTC_179 1273-0063 6.77 µM 1.13623357502251 0.121314564668247 no 456 0.127929411154467 131 3108139 SGTC_2648 atorvastatin 78.68 µM 1.13619128819494 0.12132339389392 no 457 0.127938257883188 151 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_873 0591-4978 488 µM 1.13464382199006 0.121646806041209 no 458 0.128262292110231 167 3305145 SGTC_2711 st079103 59.1 µM 1.13142684735912 0.122321074263779 no 459 0.12893773843593 143 54693780 SGTC_154 3389-1638 511.116 µM 1.13011549298998 0.12259668143974 no 460 0.129213781123483 154 5238686 SGTC_1794 st048918 76.9 µM 1.12901564048679 0.122828172991125 no 461 0.129445617919276 122 672303 SGTC_245 methotrexate 289.6 µM 1.12742072877071 0.123164406442594 no 462 0.129782319500676 145 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1062 mesoridazine 14.2 µM 1.12617946999039 0.123426530068147 no 463 0.130044780774074 143 4078 A neuroleptic. SGTC_1221 2958-7315 257 µM 1.1242471214157 0.123835372316218 no 464 0.130454102084613 164 4562705 SGTC_3082 9117008 49.47 µM 1.12028182373867 0.124677307926159 no 465 0.131296842575833 153 41448529 SGTC_3060 1327-0027 12.5 µM 1.11990823458952 0.124756836329101 no 466 0.131376434425221 157 16000455 YPR107C YTH1 SGTC_661 1304-0007 33.6 µM 1.11982155171538 0.124775294154106 no 467 0.13139490666609 164 3117130 SGTC_3291 9121177 71.43 µM 1.11722583980957 0.125328896634189 no 468 0.131948887452054 147 17015612 SGTC_1888 azatryptophan 97.5 µM 1.11479512816548 0.125848861126903 no 469 0.132469112331286 131 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_110 0850-0284 111.64 µM 1.11355272191022 0.126115210106955 no 470 0.132735559243842 125 3906265 SGTC_2859 9028643 45.46 µM 1.11289259132572 0.126256889682561 no 471 0.132877281159952 126 17151580 SGTC_2451 5856223 45.7 µM 1.112031386329 0.12644189126621 no 472 0.133062327855825 185 2179896 SGTC_492 tmb-8 126 µM 1.11174596045209 0.126503247281723 no 473 0.133123696291527 148 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_935 2996-0153 430 µM 1.11062634249255 0.126744123999032 no 474 0.133364609550153 167 23738523 SGTC_372 0155-0182 15.9 µM 1.1081878065978 0.127269859998872 no 475 0.133890357855097 151 771486 SGTC_1032 k061-1018 98.7 µM 1.10717595317662 0.12748845520361 no 476 0.134108931040171 145 4005393 SGTC_937 3122-0005 46.7 µM 1.10624134171753 0.127690595306522 no 477 0.134311036643784 165 759535 SGTC_310 1273-0058 1.06 µM 1.10478214970145 0.128006638263011 no 478 0.134626998508309 136 2734232 SGTC_3038 9091290 49.47 µM 1.09827347799511 0.129422951964701 no 479 0.136042544727872 147 25236843 SGTC_3158 9100007 49.47 µM 1.0980490587014 0.129471979425417 no 480 0.136091533862471 135 19297233 SGTC_728 3030-5151 22.5 µM 1.09743259107895 0.129606721417908 no 481 0.136226166492981 156 3125388 SGTC_1039 k821-0043 94 µM 1.09724969761776 0.129646715315833 no 482 0.136266126793635 139 15992768 SGTC_574 1315-0397 40 µM 1.09549085291522 0.130031763903272 no 483 0.136650825349595 199 6794277 SGTC_2252 omeprazole 400 µM 1.09352540228172 0.130462978565386 no 484 0.137081591042359 135 4594 A proton pump inhibitor. SGTC_2791 5663188 71.43 µM 1.09284770549858 0.130611892484997 no 485 0.137230335980587 184 54690634 SGTC_1138 3761-0006 1.03 µM 1.09260198714245 0.130665914506304 no 486 0.137284294935247 139 12061087 SGTC_2107 5363541 170.161 µM 1.08978747046672 0.131285797537949 no 487 0.137903387246662 168 244052 SGTC_1193 1488-0126 41.5 µM 1.08780402443038 0.131723859449644 no 488 0.138340816261429 160 1384710 SGTC_908 3448-7491 47.7 µM 1.08650587900042 0.132011112030437 no 489 0.13862762066639 151 1203031 SGTC_1923 st058458 19.1 µM 1.08641642628071 0.132030921954461 no 490 0.138647398716906 197 3534982 SGTC_2085 5307070 144.047 µM 1.08517380073825 0.132306322033389 no 491 0.138922342803941 187 2840351 SGTC_2302 7771753 200 µM 1.08378909388277 0.1326136774045 no 492 0.139229160950507 171 2203047 SGTC_2126 5251174 33.877 µM 1.0816381774433 0.133092078658653 no 493 0.139706666782192 158 790722 SGTC_2659 sanguinarine 24.21 µM 1.07921657666972 0.133632104738487 no 494 0.140245595830412 158 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_548 1436-0017 110 µM 1.0771373267486 0.134096985940928 no 495 0.140709459743882 161 9677137 SGTC_3211 9128781 49.47 µM 1.07518429096291 0.134534658860659 no 496 0.141146113561951 164 17194361 SGTC_976 1348-1067 47.6 µM 1.07501984000231 0.134571556828348 no 497 0.141182922903348 158 5310671 YGL099W LSG1 SGTC_2741 miltefosine 3.04 µM 1.07476374055691 0.13462903185605 no 498 0.141240259041857 122 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_803 4488-1585 147 µM 1.07388302881867 0.134826813857798 no 499 0.141437555306085 150 747204 SGTC_1883 5-benzylidenerhodanine 20 µM 1.06943459422223 0.135828847347002 no 500 0.14243694303685 169 1273210 SGTC_1114 scopoletin 1.73284 µM 1.06851871905087 0.136035784552803 no 501 0.142643295564435 156 5280460 A coumarin with genotoxic properties. SGTC_2639 lactacystin 53 µM 1.06845063100757 0.136051177304142 no 502 0.142658644303708 158 3870 A proteasome inhibitor. SGTC_828 2074-0507 139 µM 1.06777377635932 0.136204259539728 no 503 0.142811284910001 161 X828 SGTC_863 0466-0191 129 µM 1.06677201350369 0.136431041569453 no 504 0.14303739959789 194 765160 YPR165W RHO1 SGTC_448 monastrol 171 µM 1.06580582835179 0.136650013980656 no 505 0.143255712840718 175 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_175 3793-3120 23.7 µM 1.06555732175075 0.136706373373425 no 506 0.143311900225755 183 5322297 SGTC_745 0469-0705 296 µM 1.0645238640528 0.136940924116863 no 507 0.143545724808519 203 3486736 SGTC_3300 9124615 50.48 µM 1.0638001219729 0.137105346293628 no 508 0.143709628036715 164 24824903 SGTC_1389 3405-0187 19 µM 1.06286087372842 0.137318928912711 no 509 0.143922524383651 164 799890 SGTC_2077 5212015 200 µM 1.0596171662812 0.138058286329113 no 510 0.144659400378793 166 780900 SGTC_3174 9107204 49.47 µM 1.05734527792077 0.138577745079093 no 511 0.145177018051112 172 3938802 SGTC_2827 7993847 71.43 µM 1.05617095280107 0.138846771513132 no 512 0.14544505946866 151 2985692 SGTC_1906 st060206 94.7 µM 1.0537491332398 0.139402709206639 no 513 0.145998893782577 180 5133468 SGTC_763 3453-1109 128 µM 1.0533114574412 0.139503340649545 no 514 0.146099134741471 169 1560353 SGTC_2172 5754775 163.918 µM 1.05251883480862 0.139685708031522 no 515 0.146280786883809 198 2263357 SGTC_141 0443-0274 32.331 µM 1.0498996809123 0.140289477898114 no 516 0.146882119157127 157 1627241 SGTC_525 k781-2675 26.7 µM 1.0460148794276 0.141188265759054 no 517 0.14777708133823 180 3651118 YDL195W SEC31 SGTC_2986 9022445 71.43 µM 1.04551395273008 0.141304443717522 no 518 0.147892747674965 186 6459286 SGTC_2505 galangin 7.89 µM 1.04401512531553 0.141652447804845 no 519 0.148239195892153 185 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2937 9044753 11.33 µM 1.0435521342331 0.141760064305923 no 520 0.148346324186435 162 6465530 YGL099W LSG1 SGTC_2814 7977482 42.97 µM 1.03998110336994 0.142591966323798 no 521 0.149174340004679 186 6456762 SGTC_558 k064-0027 21.3 µM 1.03695559239995 0.143299363198695 no 522 0.149878276758515 182 5088526 SGTC_1379 2144-0755 36.5 µM 1.0331910429496 0.144182859008947 no 523 0.150757251874331 188 5392327 SGTC_941 3237-0776 460 µM 1.03313483487657 0.144196078153098 no 524 0.150770401706983 168 760008 SGTC_3311 9131146 2.8755 µM 1.03236578099929 0.144377028087396 no 525 0.150950397935449 210 4900406 YPR165W RHO1 SGTC_1106 tegaserod maleate 11.7 µM 1.03184796553267 0.144498950555642 no 526 0.151071672621493 198 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2390 9097792 176.6 µM 1.03009406663595 0.144912430911525 no 527 0.151482925123749 161 4497149 SGTC_2377 9073351 62.6 µM 1.02963229926567 0.145021424565305 no 528 0.151591323554918 188 7337946 YHR072W ERG7 SGTC_1504 k297-0033 30 µM 1.02912938183856 0.145140193869465 no 529 0.151709440477803 113 4388117 SGTC_850 0388-0143 75.9 µM 1.02867973456811 0.145246438270961 no 530 0.151815097964451 164 67273 SGTC_2435 5706476 10.6 µM 1.02651891962359 0.145757733841765 no 531 0.152323525148562 164 5725375 SGTC_2935 9038016 29.96 µM 1.02553779851154 0.145990287228547 no 532 0.152554749921811 177 6463195 SGTC_1908 st060353 56.5 µM 1.02275710099372 0.146650744917394 no 533 0.153211352915233 196 4227716 SGTC_2485 5633444 17.78 µM 1.022632552298 0.146680373955688 no 534 0.153240806212999 175 5724239 SGTC_1459 k035-0031 35.7 µM 1.02250775263999 0.14671006672441 no 535 0.153270322621353 168 3877128 YMR208W ERG12 SGTC_1321 1326-2144 215 µM 1.02200852824478 0.146828884261368 no 536 0.153388432019615 184 3513030 SGTC_1299 1079-1439 3.74 µM 1.0219146560889 0.1468512334434 no 537 0.153410647570446 184 323161 SGTC_549 1661-1316 519 µM 1.02179827466388 0.146878944824156 no 538 0.153438193067962 196 2857282 SGTC_1799 st045822 46.1415 µM 1.02163150220373 0.146918660841602 no 539 0.153477670974192 177 3674992 SGTC_2360 9040895 200 µM 1.02038847159792 0.147214909196102 no 540 0.153772129594991 168 4914414 SGTC_260 nsc-65238 3.989 µM 1.01999771581189 0.147308119705724 no 541 0.153864772027351 168 3246252 SGTC_1105 epirubicin 18.1 µM 1.01870388630276 0.147617030809114 no 542 0.15417178351108 178 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_600 1495-0418 41.6 µM 1.01610949526422 0.148237766859837 no 543 0.154788623954749 204 5377768 SGTC_1501 4491-0275 38.4 µM 1.01589809761988 0.148288422859237 no 544 0.154838957438668 181 5104718 SGTC_3200 9114385 49.47 µM 1.01509216206705 0.148481650769554 no 545 0.155030948740551 164 17018030 YLR208W SEC13 SGTC_1740 st038286 13.222 µM 1.01445310074795 0.148634989212319 no 546 0.155183298683565 179 716786 SGTC_605 1315-0399 119 µM 1.01427628972239 0.148677432512346 no 547 0.155225467251563 190 24020461 SGTC_3275 9138069 49.47 µM 1.01300952326436 0.148981755402738 no 548 0.155527806079203 206 17617007 SGTC_2988 9073640 71.4286 µM 1.00989445927711 0.149731874670708 no 549 0.156272928764781 182 9102229 SGTC_793 0488-0545 106 µM 1.00935838015186 0.14986121823559 no 550 0.156401395562218 194 292548 SGTC_1192 1488-0095 21.4 µM 1.00919765798135 0.149900011315016 no 551 0.156439924809874 175 915875 SGTC_1485 3909-9022 254 µM 1.0083019344933 0.150116332349338 no 552 0.15665476729879 193 714516 SGTC_1633 st005664 67.9 µM 1.00572083949269 0.150740841089556 no 553 0.15727493784246 169 2063822 SGTC_2815 7968870 71.43 µM 1.00415223700189 0.151121216144421 no 554 0.157652620047102 171 2977326 YHR190W ERG9 SGTC_1035 k081-0041 55.2 µM 1.00029222212878 0.152059959726284 no 555 0.158584555062632 198 731709 SGTC_2878 9043973 25.97 µM 0.996023241935142 0.15310266311646 no 556 0.15961942629228 175 6465167 SGTC_445 e6 berbamine 66 µM 0.988284157403695 0.155004999397087 no 557 0.161506751039953 208 6610268 A calcium/calmodulin antagonist. SGTC_3061 glucosamine 200 µM 0.986992852941556 0.155323926634477 no 558 0.161823071164774 163 91431 and experimental redox chemotherapeutic SGTC_2943 9068529 45.32 µM 0.986928194163616 0.155339907479759 no 559 0.161838920694056 226 3270634 SGTC_696 1560-0013 611 µM 0.9853420286761 0.155732278584909 no 560 0.162228047385044 216 1650269 SGTC_1758 st042942 75.2445 µM 0.984283564022443 0.155994475150496 no 561 0.162488054251631 196 669317 SGTC_3043 9092303 49.47 µM 0.984065985513106 0.156048408434851 no 562 0.162541534971943 167 25236084 SGTC_1767 st044992 70.3 µM 0.982740495301794 0.156377235919423 no 563 0.162867587383002 190 9600693 SGTC_2784 7567673 72.73 µM 0.982400341859226 0.156461694682545 no 564 0.162951328991644 185 3471247 SGTC_1652 st011932 78 µM 0.981696492515905 0.156636553074705 no 565 0.163124696948058 190 1551076 SGTC_1952 st077036 64.1 µM 0.981112665332632 0.156781691742188 no 566 0.163268592688479 174 2937007 SGTC_1791 st048313 56.1 µM 0.98110592447486 0.156783368027197 no 567 0.16327025458748 169 1204976 SGTC_2156 5649887 115 µM 0.980291594086586 0.156985958679535 no 568 0.163471101422664 192 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_198 3454-2873 16.191 µM 0.978477447618876 0.157437904342851 no 569 0.16391912005058 206 710957 SGTC_2928 9011484 9.79 µM 0.977592190217903 0.157658752498458 no 570 0.164138030745993 202 2994751 SGTC_3304 9125678 46.087 µM 0.977467365050586 0.157689909419128 no 571 0.164168913358716 193 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2948 9070189 9.45 µM 0.975285550921508 0.158235153185639 no 572 0.164709317863843 165 6473636 YDL196W YDL196W SGTC_3049 9092223 49.47 µM 0.975009330860783 0.158304269766972 no 573 0.164777815762646 164 8623917 SGTC_2888 9058547 12.99 µM 0.973767911968254 0.158615145718388 no 574 0.165085894423691 154 16476514 SGTC_303 1348-1668 34.2 µM 0.973624269203655 0.158651142542709 no 575 0.165121565809314 182 5380509 SGTC_345 1362-0200 395 µM 0.973430617307094 0.158699680114938 no 576 0.16516966406081 181 1419823 SGTC_855 0428-0020 25 µM 0.971641201404724 0.159148645993756 no 577 0.165614538883884 178 6812414 SGTC_156 3474-0145 5.642 µM 0.969184710899575 0.159766335147758 no 578 0.166226518996225 180 2265471 SGTC_2851 9015922 71.43 µM 0.967619412147603 0.160160749523913 no 579 0.166617239376679 212 2996893 SGTC_1855 st056195 39.6 µM 0.96586456193576 0.160603682098426 no 580 0.167055978597491 181 4028379 SGTC_1514 1189-1591 158 µM 0.963404773937221 0.16122588981104 no 581 0.167672215747818 211 767698 YMR146C TIF34 SGTC_1973 st070275 50.2 µM 0.9633506468858 0.161239599003357 no 582 0.167685792341368 168 17118334 SGTC_1641 st009299 47.1 µM 0.962897698569815 0.161354350662188 no 583 0.16779943232425 191 4046054 SGTC_2011 4012611 177 µM 0.962574930645499 0.161436154415496 no 584 0.167880441661698 168 2049887 SGTC_1293 1000-1278 195 µM 0.962478265363094 0.16146065896078 no 585 0.167904707925263 190 678847 SGTC_1690 st023502 41.2 µM 0.960223102371647 0.162033028637348 no 586 0.16847147102981 191 24207482 SGTC_3055 9094636 49.47 µM 0.959197292490434 0.162293820174798 no 587 0.168729682096756 213 25236176 SGTC_811 0416-0114 265 µM 0.957364599427618 0.162760425327969 no 588 0.169191629968391 190 6612453 SGTC_2486 5283202 22.39 µM 0.956407505797161 0.16300444860961 no 589 0.169433197055728 184 1377751 SGTC_2685 mycophenolic acid 18.85 µM 0.956357400577457 0.163017230125278 no 590 0.169445849532101 187 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3118 9124250 49.47 µM 0.95611953964334 0.163077915789885 no 591 0.16950592200129 177 1504786 SGTC_1 0258-0098 57.368 µM 0.955685114207761 0.163188789018913 no 592 0.169615672671328 181 6790032 YDR047W HEM12 SGTC_2371 9071574 200 µM 0.955516290086281 0.163231889202262 no 593 0.169658335694937 199 45596039 SGTC_881 0833-0569 170 µM 0.955459098903581 0.163246491580022 no 594 0.16967278986325 176 5418700 SGTC_1629 st005085 44.9 µM 0.955340449429616 0.163276788544884 no 595 0.169702779163265 218 24207091 SGTC_1038 k292-0204 154 µM 0.954957437102427 0.163374615096493 no 596 0.169799610811835 186 4454212 SGTC_2223 6903751 107.57 µM 0.952279953683751 0.164059543871706 no 597 0.170477510782451 196 5598863 SGTC_969 1313-0238 134 µM 0.947505500368126 0.16528551530126 no 598 0.171690627389025 224 5212874 SGTC_416 estradiol valerate 100 µM 0.947225845931691 0.165357507551866 no 599 0.171761853914121 216 13791 A steroid. SGTC_1245 0418-0076 17.2 µM 0.944952600926126 0.165943468222907 no 600 0.172341537632937 189 6790114 SGTC_872 0588-0139 234 µM 0.944918697457081 0.165952217459684 no 601 0.172350192545769 169 2047100 SGTC_161 4065-0411 162.148 µM 0.939705431889814 0.167301116185985 no 602 0.173684339062445 198 1906281 YLR208W SEC13 SGTC_1240 0356-0016 42.1 µM 0.937491066691859 0.167876201087343 no 603 0.174253008410588 186 4305613 SGTC_2853 9015042 58.44 µM 0.937085503532618 0.167981666172424 no 604 0.174357288809989 186 6457456 SGTC_1619 st003326 88.7 µM 0.936652788076302 0.16809423911623 no 605 0.174468594450438 167 2849032 SGTC_693 4161-2696 114 µM 0.9366368329798 0.168098390836745 no 606 0.174472699377703 231 805759 SGTC_1450 4112-4260 37.6 µM 0.936410522404273 0.168157286853354 no 607 0.174530931169184 210 1633175 SGTC_2341 7987486 176.74 µM 0.935970253020929 0.168271902443725 no 608 0.174644251888118 187 1258686 SGTC_2453 5731132 22.18 µM 0.931016171784296 0.169565064140542 no 609 0.175922599448698 216 1362040 SGTC_1201 1889-3372 45.9 µM 0.928299401495908 0.170276921216534 no 610 0.176626142228547 202 5392199 SGTC_2710 st078562 53.7235 µM 0.926443746232621 0.170764244936908 no 611 0.177107709331113 206 17250908 SGTC_1847 st056231 15 µM 0.926384806524047 0.170779738026159 no 612 0.177123018543958 197 5393180 SGTC_682 0kpi-0099 17 µM 0.926269573940813 0.170810031047659 no 613 0.177152951886188 233 1714895 YML126C ERG13 SGTC_140 0062-0056 502.533 µM 0.924157605061922 0.171365846868711 no 614 0.17770213243518 173 3758964 SGTC_2024 5144227 134 µM 0.924131582222718 0.171372702612309 no 615 0.17770890591144 187 3475211 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.922992811908445 0.17167288450957 no 616 0.178005475585858 214 756377 SGTC_49 0717-0965 32.132 µM 0.922732290454609 0.171741605616405 no 617 0.178073366963229 212 5889349 YGL099W LSG1 SGTC_797 k781-0471 270 µM 0.922271134209658 0.17186329382524 no 618 0.178193583389736 216 23738129 SGTC_1594 piperine 70.1 µM 0.921039953282373 0.17218844295218 no 619 0.178514784062908 191 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2440 5628896 157.78 µM 0.919152069998923 0.172687786046471 no 620 0.179008018520046 207 5522048 SGTC_1241 0364-0022 50.8 µM 0.917262199741939 0.173188578335742 no 621 0.179502630081799 215 4563895 SGTC_2278 7948257 134.34 µM 0.915886215742037 0.173553778352884 no 622 0.179863288646087 198 1247028 SGTC_3170 9103054 49.47 µM 0.913545808233846 0.174176070839911 no 623 0.180477776449131 209 16432970 SGTC_1128 3448-9350 235 µM 0.912950063596484 0.174334699925045 no 624 0.180634402744322 174 619386 SGTC_1725 st036284 20.55 µM 0.912884900913755 0.174352056377444 no 625 0.180651539733829 195 707914 SGTC_3127 9126946 49.47 µM 0.912693683552742 0.174402994549992 no 626 0.180701833448744 187 27243249 SGTC_2425 5628681 7.85 µM 0.907805642650248 0.175708322782097 no 627 0.181990458323575 205 5714958 SGTC_87 0100-0052 35.5 µM 0.907626625379513 0.17575624569934 no 628 0.182037761122249 222 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2650 prasterone 100 µM 0.907507983697265 0.175788010635325 no 629 0.182069114755004 178 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2959 9079155 11 µM 0.90363632437494 0.176826597757715 no 630 0.183094136751067 205 16189457 SGTC_1258 0671-0043 57.1 µM 0.903191164566517 0.176946261665907 no 631 0.183212223156529 218 4298767 SGTC_2199 6590217 200 µM 0.900940007268182 0.17755218124165 no 632 0.183810109087333 188 703109 SGTC_1374 2889-5571 141 µM 0.899867836727836 0.177841225566754 no 633 0.184095294135527 230 2853281 SGTC_1753 st043925 64 µM 0.899218152382617 0.178016517007486 no 634 0.184268236655727 201 670181 SGTC_1392 3455-1037 33.9 µM 0.898978144289939 0.178081301177715 no 635 0.184332151099209 194 981132 SGTC_316 k060-0003 58.6 µM 0.898415927617307 0.178233115659811 no 636 0.18448192406665 214 6152314 SGTC_1470 k295-0292 231 µM 0.897526599772034 0.178473425960423 no 637 0.184718993060621 226 5045612 SGTC_805 3852-0218 479 µM 0.895774778799454 0.178947392073983 no 638 0.185186531371655 207 6615355 SGTC_1222 0366-0074 1.18 µM 0.895172220800795 0.179110600821242 no 639 0.185347516017569 222 286520 SGTC_1047 2043-3044 82 µM 0.889743452254243 0.180585255816555 no 640 0.186801828172521 241 669592 SGTC_2213 7173844 200 µM 0.88374226677935 0.182224233979374 no 641 0.188417679128357 217 892728 SGTC_2347 9049783 174.81 µM 0.882525367398745 0.182557710481273 no 642 0.188746383965032 234 6467988 YPL169C MEX67 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.880746359765959 0.183045911320073 no 643 0.189227559199988 205 279621 SGTC_1562 morin hydrate 59.1 µM 0.880329674792604 0.18316037694193 no 644 0.189340370706501 206 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1025 k007-0731 70 µM 0.878888696173986 0.183556565652266 no 645 0.189730814117918 200 6256118 SGTC_943 3253-1379 105 µM 0.878600320816823 0.183635916874568 no 646 0.189809010897543 221 668464 SGTC_2775 cyproheptadine 69.59 µM 0.875004609396582 0.184627130175391 no 647 0.19078569884566 223 2913 A selective serotonin reuptake inhibitor. SGTC_2786 7743617 45.45 µM 0.873706353582343 0.184985830326245 no 648 0.191139094992773 200 583674 SGTC_1279 0874-0590 65.2 µM 0.872581824614258 0.185296880526048 no 649 0.191445525403921 215 3523074 SGTC_1066 ketoconazole 628 nM 0.872226259522314 0.185395299103158 no 650 0.191542478313408 225 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2068 5226020 147 µM 0.871617408108062 0.185563901366542 no 651 0.191708565334712 221 1810509 SGTC_531 3788-1495 174 µM 0.871367910502743 0.185633019363072 no 652 0.191776650615987 206 2896655 SGTC_2745 rifampicin 24.3 µM 0.867021930169716 0.186839541986103 no 653 0.19296499697463 162 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_571 k831-0106 44.2 µM 0.865489578982121 0.18726610500246 no 654 0.193385066605348 227 4783639 SGTC_1183 1254-0324 198 µM 0.865463048417168 0.187273495656642 no 655 0.19339234444673 200 5799357 SGTC_370 0180-0345 38.7 µM 0.865369008671812 0.187299693884042 no 656 0.193418142693406 196 3989527 SGTC_991 3996-0057 64.7 µM 0.86404684212006 0.187668271819172 no 657 0.193781079432808 203 715343 SGTC_3204 9114183 49.47 µM 0.861913461197508 0.18826393450621 no 658 0.194367570440127 206 17027248 SGTC_973 1325-0077 65.9 µM 0.861314599979338 0.188431352395024 no 659 0.194532398352802 203 2835149 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.857784286536996 0.189420153320267 no 660 0.195505794022074 192 77254 SGTC_2328 6201408 200 µM 0.856803387644641 0.189695457918657 no 661 0.195776776587061 239 2890418 SGTC_1165 k072-0275 30.3 µM 0.855152433751649 0.190159379286904 no 662 0.196233382581051 220 6153523 YGL055W OLE1 SGTC_1152 3909-8331 15.9 µM 0.854867502080005 0.190239516144162 no 663 0.196312251707078 208 16001939 SGTC_1914 st062367 72.6 µM 0.854588550576644 0.190317991178313 no 664 0.196389484134261 224 978205 SGTC_381 3461-2219 42.7 µM 0.852832420186141 0.190812484767591 no 665 0.196876121229623 218 2883159 SGTC_2225 6654152 15.4 µM 0.852795107105191 0.190822999981655 no 666 0.196886468883029 224 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_916 4466-0038 42 nM 0.852725710087336 0.190842557728175 no 667 0.196905714920728 241 5722064 YGL116W CDC20 SGTC_1236 0330-0013 258 µM 0.852149824690501 0.191004903510601 no 668 0.197065470507793 220 4617066 SGTC_1455 4262-0120 131 µM 0.851148433275339 0.191287403793126 no 669 0.197343451868297 208 1529587 SGTC_1583 clindamycin 39.6 µM 0.850034836376114 0.191601858696208 no 670 0.197652859280022 234 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_386 1509-0011 3.07 µM 0.84995993749529 0.1916230198263 no 671 0.197673680083122 216 3107280 SGTC_344 k064-0035 6.43 µM 0.849010270188765 0.19189145281355 no 672 0.197937788768407 214 5088750 SGTC_72 0744-0168 198.391 µM 0.843765728239378 0.193378016923617 no 673 0.199400165084366 235 677577 SGTC_2458 5808907 16.39 µM 0.840333585144126 0.194354650152429 no 674 0.200360687832901 248 2731747 SGTC_2144 5628481 200 µM 0.840275604964025 0.194371174450717 no 675 0.200376938058477 211 2818399 SGTC_396 dithiazanine 1.25 µM 0.839730763583642 0.194526495526448 no 676 0.200529680558245 193 10578 An antihelmenthic. SGTC_1578 josamycin 24.2 µM 0.839260936658134 0.19466049243482 no 677 0.200661449402314 230 5282165 A P450 substrate. SGTC_2794 7785382 27.27 µM 0.838944460461879 0.194750784622105 no 678 0.200750238407392 231 2205081 SGTC_561 1550-0330 72.9 µM 0.837739585549021 0.195094774326232 no 679 0.20108848791415 216 6812934 SGTC_1570 verbenone 133 µM 0.836464358959888 0.195459251333246 no 680 0.201446859626113 225 29025 A natural terpanoid with antifungal properties. SGTC_1833 st055984 71 µM 0.833927356253985 0.19618558976316 no 681 0.202160960299525 208 676288 SGTC_2873 9040596 71.43 µM 0.83392021146248 0.196187637610057 no 682 0.202162973509918 242 6463863 SGTC_2256 7954252 200 µM 0.833125932296118 0.196415375465277 no 683 0.202386854831584 225 2972920 SGTC_65 0798-0905 34.986 µM 0.833122285889069 0.196416421342229 no 684 0.202387882976256 222 3602145 SGTC_2352 9027995 87.8 µM 0.830989702268517 0.197028675547029 no 685 0.202989723386498 210 2997347 SGTC_2882 9058044 58.44 µM 0.830805486434318 0.197081617145983 no 686 0.203041761382407 231 18076804 SGTC_10 0279-0212 42.575 µM 0.830692498602806 0.197114092861576 no 687 0.203073682559541 228 39851 YBR002C RER2 SGTC_2366 9070441 60.58 µM 0.829474922585958 0.197464262113557 no 688 0.203417860658914 211 6837235 SGTC_1553 gossypol 38.6 µM 0.828084724780504 0.197864536179108 no 689 0.203811259816896 219 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3107 9121808 49.47 µM 0.827398543227579 0.198062286226951 no 690 0.204005603003903 200 662681 SGTC_1271 0832-2808 169 µM 0.825760312890767 0.198534888710257 no 691 0.20447003564373 249 3663794 SGTC_391 gliotoxin 8.33 µM 0.825531061331452 0.198601078225493 no 692 0.204535077823482 228 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2403 6032726 181.2 µM 0.82452653131363 0.19889126304709 no 693 0.204820223519329 224 2881040 SGTC_1004 4084-0029 199 µM 0.82418028437543 0.198991344745295 no 694 0.204918563868183 223 716894 YLR208W SEC13 SGTC_36 0335-0881 14.2 µM 0.823246841150292 0.199261305016458 no 695 0.205183818325129 230 23828853 SGTC_767 0929-0023 86 µM 0.821182219640269 0.199859195257066 no 696 0.205771241365739 245 1204563 SGTC_66 0109-0187 42.4 µM 0.819600544965857 0.200317958813502 no 697 0.206221931440603 180 759417 SGTC_1122 capsaicin 818.572 nM 0.819213882641976 0.200430206097566 no 698 0.206332197827554 228 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1765 st044815 90.4 µM 0.818018598833827 0.200777433378951 no 699 0.206673283643362 248 645695 SGTC_1803 st050068 52.4 µM 0.817738763596062 0.200858777017893 no 700 0.206753185548023 248 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_563 tetrahydrosecaminediol 614 µM 0.816971458409194 0.201081921827115 no 701 0.206972369510599 214 334274 A psychoactive constituent of the cannabis plant. SGTC_747 3448-8087 38.7 µM 0.815639807009699 0.201469540436721 no 702 0.207353087571632 228 5168703 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.814379914079034 0.201836683410957 no 703 0.207713670846706 251 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2285 7945142 200 µM 0.814051710461722 0.201932390325473 no 704 0.207807664002703 235 2970608 SGTC_358 0075-0058 9.45 µM 0.814014038836241 0.201943377423742 no 705 0.207818454262726 257 1069125 SGTC_3185 9108267 49.47 µM 0.813684520646404 0.202039498133554 no 706 0.207912852056042 243 4910486 SGTC_968 1309-0633 340 µM 0.810473583129141 0.202977563638873 no 707 0.208834020914702 239 3761976 SGTC_3122 9126309 49.47 µM 0.809881186471995 0.203150914269863 no 708 0.209004232827023 266 17591206 SGTC_911 3456-4043 236 µM 0.808701300996358 0.203496442572116 no 709 0.20934348983182 232 914281 SGTC_1371 2421-0008 32.7 µM 0.808626688788968 0.20351830446227 no 710 0.20936495425589 238 2827552 SGTC_406 estrone 100 µM 0.805223349852602 0.204516994780563 no 711 0.210345402220382 229 5870 A steroid. SGTC_2839 9003951 25.97 µM 0.804193167517584 0.204819869939244 no 712 0.210642712067196 222 2990634 SGTC_2960 9079389 5.97 µM 0.803064505333702 0.20515200434395 no 713 0.210968725992756 207 16457355 SGTC_1958 st076513 41.9 µM 0.802242370792935 0.20539413739715 no 714 0.211206385555856 246 732122 YGL099W LSG1 SGTC_2601 securinine 100 µM 0.801889206845053 0.205498202472269 no 715 0.211308525011413 276 442872 A GABA receptor antagonist. SGTC_3129 9127257 49.47 µM 0.799491604930938 0.206205519305868 no 716 0.212002706288198 233 837894 SGTC_2286 7945697 125 µM 0.797632280189361 0.206755031178505 no 717 0.212541956396002 227 1245733 SGTC_2112 5488546 200 µM 0.797116713597706 0.206907557076098 no 718 0.212691625201933 248 600757 SGTC_2742 clothiapine 36.27 µM 0.796392829771426 0.207121824173297 no 719 0.212901872257494 203 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2842 9000675 19.48 µM 0.795733399092915 0.207317127563658 no 720 0.21309350487212 245 2989072 SGTC_2375 9072683 200 µM 0.795715090568015 0.207322551547236 no 721 0.213098826821829 253 16798029 SGTC_2233 sulbentine 40.3845 µM 0.795476604520964 0.207393211785372 no 722 0.213168157389113 243 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1505 k297-0037 20.6 µM 0.795165919171841 0.207485285066357 no 723 0.213258496832728 232 4089396 SGTC_2491 paeonol 100 µM 0.79484271557064 0.207581093834225 no 724 0.213352499955414 248 11092 Increases levels of cortical cytochrome oxidase. SGTC_2407 paclitaxel 400 µM 0.792867310185404 0.208167240517174 no 725 0.213927567458486 247 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1734 st037168 69.4 µM 0.792086819935355 0.208399098243002 no 726 0.21415502731228 223 708907 SGTC_2346 9031566 143.75 µM 0.792081633830359 0.208400639371739 no 727 0.214156539179851 234 4771086 SGTC_1695 st026914 34.495 µM 0.790791136829641 0.2087843387791 no 728 0.214532941420257 235 3289191 SGTC_204 PMA1.184 62.41 µM 0.789050351660332 0.209302579927264 no 729 0.215041289071003 258 2252213 YGL008C PMA1 SGTC_2625 euphol 100 µM 0.786841106603067 0.209961373068019 no 730 0.21568744334323 249 6708538 A triterpene alcohol. SGTC_318 1488-0629 67.2 µM 0.786618140229871 0.210027928893152 no 731 0.215752718445613 241 3662576 SGTC_1457 k015-0032 57.3 µM 0.785413693920748 0.210387672363584 no 732 0.216105527214366 243 4302660 SGTC_581 0958-0271 211 µM 0.785186565302293 0.21045555155211 no 733 0.216172095600178 238 4591145 SGTC_3034 9090421 49.47 µM 0.785127778293793 0.210473122609709 no 734 0.21618932722695 219 17173761 SGTC_3083 9117465 49.47 µM 0.783587028270592 0.210933949797399 no 735 0.216641234841157 256 16420915 SGTC_861 0443-0273 110 µM 0.78233787982428 0.211307994921777 no 736 0.217008015384482 241 6149169 SGTC_219 mitoxanthrone 164.414 µM 0.780070728071138 0.211987862739609 no 737 0.217674622532834 245 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2499 avocadenofuran 51.48 µM 0.777482422210599 0.212765599319241 no 738 0.21843710057639 237 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1100 amiodarone 5.07 µM 0.776529493296038 0.213052355300376 no 739 0.218718206804044 229 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2817 7995342 71.43 µM 0.775685064271616 0.213306649746371 no 740 0.218967480354363 247 18879975 SGTC_1648 st011736 69.8 µM 0.774140537522513 0.213772231770193 no 741 0.219423843714102 248 2855514 SGTC_2858 9025781 8.96 µM 0.772162345972689 0.214369401276662 no 742 0.220009139989628 238 4894980 YPL153C RAD53 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.769256417864247 0.215248389678652 no 743 0.220870552032471 242 5377381 SGTC_3288 9119690 36.221 µM 0.7685924409204 0.215449523345882 no 744 0.221067647160578 260 17595618 YKL019W RAM2 SGTC_1394 3474-0001 65.7 µM 0.767502290324866 0.215779991008209 no 745 0.221391465991406 212 5017666 YIL048W NEO1 SGTC_186 3455-3465 67.277 µM 0.767363925226166 0.215821955931007 no 746 0.221432585411298 248 755278 SGTC_2829 7992743 58.44 µM 0.764131079022112 0.216803795394489 no 747 0.222394566578826 235 16462845 SGTC_3047 9092122 49.47 µM 0.764032644932914 0.216833731019838 no 748 0.222423894444171 247 17173831 SGTC_2206 7254556 146.969 µM 0.762794897859466 0.217210356678512 no 749 0.222792862207071 219 4398905 SGTC_1420 4'-methoxyflavone 42 µM 0.761592132716615 0.217576699665121 no 750 0.223151735877948 246 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2898 9056270 58.44 µM 0.760023959118983 0.218054875339547 no 751 0.223620131783263 202 19154699 SGTC_1452 4194-0072 190 µM 0.75775288755826 0.218748455162743 no 752 0.22429946558077 244 1343545 SGTC_2311 7694451 200 µM 0.757598081365026 0.218795778779209 no 753 0.224345814564456 268 2163142 SGTC_2920 7982904 15.77 µM 0.756431324970642 0.219152640881413 no 754 0.224695316352441 237 6456808 SGTC_703 3875-0075 71.8 µM 0.755659395402681 0.219388925753615 no 755 0.224926717430934 286 2850814 SGTC_2315 7733312 200 µM 0.755195894262052 0.219530872097494 no 756 0.225065725898021 245 726316 SGTC_825 1988-2224 89.6 µM 0.753204230621938 0.220141415337647 no 757 0.225663598742661 251 1180859 SGTC_2204 7233102 200 µM 0.752235465625781 0.22043874134937 no 758 0.225954734571901 244 2172480 SGTC_2289 7946404 165.07 µM 0.75186873198548 0.220551356485894 no 759 0.22606500172584 244 1246120 YPR165W RHO1 SGTC_1017 4239-0030 168 µM 0.750630161488167 0.220931935455658 no 760 0.226437632013493 247 1149593 SGTC_1749 st037932 54.2 µM 0.75025389473536 0.221047626384549 no 761 0.226550902448115 263 594497 SGTC_890 0929-0006 47.2 µM 0.74918226515221 0.221377310788602 no 762 0.226873678449976 238 1378169 SGTC_1813 st051246 8.6015 µM 0.747973875159792 0.221749406281608 no 763 0.227237957809422 236 5291959 SGTC_1674 st016616 23.6 µM 0.747402386645592 0.221925507204504 no 764 0.227410352588783 240 625830 SGTC_64 000l-0018 272.079 µM 0.747027095230942 0.222041194539893 no 765 0.227523602769441 255 6811119 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.74672106397133 0.222135557217741 no 766 0.227615976096799 249 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2675 theaflavin digallate 100 µM 0.746602861072589 0.222172010412179 no 767 0.227651660440903 251 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2028 5153890 36.43 µM 0.746366854394674 0.22224480392681 no 768 0.227722918059793 261 2830968 YPR165W RHO1 SGTC_1882 5615643 20 µM 0.744437608805689 0.222840367379135 no 769 0.228305886745978 240 2253075 SGTC_627 1391-0720 175 µM 0.744387800295461 0.222855755435908 no 770 0.228320948703372 287 997839 SGTC_591 4299-0174 154 µM 0.743814674415499 0.223032862982856 no 771 0.228494300582708 266 5509088 SGTC_487 nimodipine 119 µM 0.743530574898884 0.223120685214933 no 772 0.22858025882008 239 4497 L-type voltage-gated calcium channels inhibitor SGTC_155 k072-0202 43.6 µM 0.743409758026848 0.223158038683524 no 773 0.228616819138909 263 5857737 SGTC_122 0236-0016 402.397 µM 0.742287396761121 0.2235052140279 no 774 0.228956613106675 275 6808838 SGTC_376 3970-0862 59.1 µM 0.739361006500664 0.224411865556427 no 775 0.229843906773654 271 3135186 SGTC_1722 st034304 3.6505 µM 0.739119116255806 0.224486901054367 no 776 0.229917334941575 258 4036148 YLR033W RSC58 SGTC_1736 st036774 51 µM 0.738498496609347 0.224679485313155 no 777 0.230105790203602 268 1272247 SGTC_3321 9137793 26.8275 µM 0.738471353173469 0.224687910321213 no 778 0.230114034459634 257 4904192 SGTC_3235 9132602 49.47 µM 0.737922225754621 0.22485839158556 no 779 0.230280856016318 260 4912240 SGTC_2879 9041815 71.43 µM 0.737602724485899 0.224957617201214 no 780 0.230377949666136 227 4942971 SGTC_1796 st049173 110.4 µM 0.737500801950725 0.224989275899412 no 781 0.230408927850623 278 94134 SGTC_822 1487-0950 154 µM 0.737128151500864 0.225105048319275 no 782 0.230522210497321 236 1958375 SGTC_907 3448-6986 75.5 µM 0.736534188585435 0.225289646293208 no 783 0.230702834630344 255 590582 SGTC_2065 5221596 34.26 µM 0.734543844742408 0.225908850624432 no 784 0.231308674225609 254 788581 SGTC_1600 coumarin 106 71.1 µM 0.733381135055821 0.226271019314421 no 785 0.231663000961177 260 100336 A hepatotoxic, DNA x-linker. SGTC_1468 k284-1086 134 µM 0.732476411618079 0.226553055466598 no 786 0.231938917510082 254 15996457 SGTC_2739 tacrine 100.86 µM 0.731160005028637 0.226963782905983 no 787 0.232340713113841 240 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_712 r015-0009 80.6 µM 0.728892404946886 0.227672272652284 no 788 0.233033740526729 263 6813872 YLR060W FRS1 SGTC_522 1273-0010 11.6 µM 0.727814453370882 0.228009504323714 no 789 0.233363587858172 261 5705015 SGTC_2118 5526350 200 µM 0.727404526078176 0.22813782169424 no 790 0.233489091338243 261 743594 SGTC_2134 5324836 1.464 µM 0.727116876396818 0.2282278873892 no 791 0.233577180610432 278 699272 SGTC_719 2810-4230 27.3 µM 0.724819597591674 0.228947902840706 no 792 0.234281355674291 262 721079 SGTC_1087 pterostilbene 9.05 µM 0.720814431508017 0.230206249052603 no 793 0.235511847537321 279 5281727 Similar to reservatol, lowers cholesterol. SGTC_1302 1159-0335 255 µM 0.718568996858056 0.230913410396876 no 794 0.236203260774815 255 649284 SGTC_2576 guaiol 23.12 µM 0.718539990143401 0.230922553495242 no 795 0.236212199817755 248 227829 SGTC_774 k060-0086 136 µM 0.71621263523755 0.23165680874659 no 796 0.236930031157362 260 5911235 SGTC_365 0121-0052 13.6 µM 0.715944098965785 0.2317416126716 no 797 0.237012933502178 230 3101739 SGTC_1664 st014217 9.02 µM 0.715677542119716 0.231825808596063 no 798 0.237095240524248 264 3982782 SGTC_660 4031-1742 102 µM 0.714264974418445 0.232272273303439 no 799 0.237531673087055 259 6738706 SGTC_1186 1319-0216 26 µM 0.713734715805455 0.232439993474809 no 800 0.237695617661207 275 4565136 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.71330045492367 0.232577399831088 no 801 0.237829928022947 294 5393153 SGTC_1880 MG-132 525 µM 0.713099642452237 0.232640955036863 no 802 0.237892050371598 258 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3263 9137018 49.47 µM 0.712376755910769 0.232869821548145 no 803 0.238115752608545 264 43844957 SGTC_3297 9117502 71.43 µM 0.712126194338847 0.232949178742851 no 804 0.238193317513567 246 7453720 SGTC_641 4092-0595 30 µM 0.711714489635266 0.233079605373204 no 805 0.238320796626384 258 786260 SGTC_2933 9026794 32.47 µM 0.711563428614716 0.233127471149692 no 806 0.238367580114706 258 17586027 SGTC_2053 5265679 138 µM 0.711466245424693 0.233158267873963 no 807 0.23839768033647 289 764595 SGTC_193 1273-0060 1.558 µM 0.711105387169422 0.233272641281075 no 808 0.238509465958094 264 2847393 YHR072W ERG7 SGTC_521 r062-0005 13.8 µM 0.710157514656452 0.233573216110964 no 809 0.238803231781809 247 2832033 SGTC_1237 0330-0133 46.1 µM 0.709440658725645 0.233800677055633 no 810 0.239025532037577 283 X1237 YHR072W ERG7 SGTC_1453 4237-0541 195 µM 0.709414618825407 0.233808941918947 no 811 0.239033609256864 252 739892 SGTC_1742 st038235 28.8875 µM 0.703794792270067 0.235596414905171 no 812 0.24078028866493 283 564103 YBR002C RER2 SGTC_169 k015-0017 16.025 µM 0.702673963121247 0.235953811502262 no 813 0.241129478651144 316 1840002 SGTC_107 0358-0022 2.6945 µM 0.702624767883554 0.235969505133737 no 814 0.241144811541618 285 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2679 rapamycin 1 nM 0.700647696936531 0.236600680726292 no 815 0.241761452162141 251 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2737 bleomycin 30.5 nM 0.700428071747855 0.236670852868015 no 816 0.241830005164809 267 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3124 9127567 49.47 µM 0.70024264841013 0.236730106135337 no 817 0.241887890737702 249 17592030 SGTC_1621 st003705 32.4 µM 0.69933019424429 0.237021805796008 no 818 0.242172850728239 268 24207032 SGTC_1294 1000-1494 117 µM 0.699230492475097 0.237053691114625 no 819 0.242203998676893 260 712797 YDL207W GLE1 SGTC_3053 9095903 49.47 µM 0.699003212164592 0.237126385747846 no 820 0.242275011706999 309 17174018 SGTC_3015 9080845 49.47 µM 0.697269607640095 0.237681274542591 no 821 0.242817042188772 263 5296973 SGTC_512 prima-1 270 µM 0.696720252466622 0.237857259612814 no 822 0.24298894094426 252 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1720 st037298 9.481 µM 0.696279983615308 0.237998350615564 no 823 0.24312675299717 282 597396 SGTC_2581 avocatin a 64 µM 0.695629015135024 0.238207047630663 no 824 0.243330595234604 280 6710728 A skin care supplement. SGTC_5 0352-0601 109.883 µM 0.695433588507099 0.238269719925334 no 825 0.243391808539999 258 762456 SGTC_1049 3226-0134 66 µM 0.695305765722139 0.238310716907621 no 826 0.243431850855588 260 5702385 SGTC_1088 bifonazole 369 nM 0.695116403287216 0.23837145878598 no 827 0.243491177888187 258 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_495 decylubiquinone 155 µM 0.693937796152883 0.238749711703569 no 828 0.243860609675892 281 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3128 9127691 49.47 µM 0.693290269352555 0.238957663549803 no 829 0.244063704183962 272 41316314 SGTC_2057 5236571 38.335 µM 0.692409481389981 0.239240685626978 no 830 0.244340106616856 263 54684039 YBR257W POP4 SGTC_2621 lithochol-11-enic acid 100 µM 0.691543310477712 0.239519189356249 no 831 0.244612086480166 280 6708711 SGTC_2064 5220758 200 µM 0.690657258568689 0.239804268563968 no 832 0.244890477642934 265 788518 SGTC_2398 5228213 48.84 µM 0.690129959088447 0.239974010235325 no 833 0.245056232254984 276 80771 YMR134W ERG29 SGTC_326 k292-0812 17.5 µM 0.685640644275824 0.241421804498464 no 834 0.246469872366984 272 3579357 SGTC_2669 eugenol 100 µM 0.6855737843804 0.241443402469194 no 835 0.246490958848684 249 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_715 0868-0130 184 µM 0.684628363376213 0.241748917226235 no 836 0.246789232107335 283 2876258 SGTC_3075 9116269 49.47 µM 0.684162545233491 0.241899524446326 no 837 0.246936265276123 277 17015205 YNL244C SUI1 SGTC_485 niflumic acid 177 µM 0.68336212237496 0.242158434109534 no 838 0.247189024196157 277 4488 A COX2 inhibitor. SGTC_595 3909-8003 73.7 µM 0.682366431352492 0.242480715975277 no 839 0.2475036382386 290 699517 SGTC_263 alizarin 107.927 µM 0.681562079999744 0.242741235227498 no 840 0.247757949767949 292 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_280 3448-3607 3.04 µM 0.681539182700046 0.24274865359111 no 841 0.247765191242274 258 626179 SGTC_1683 st010134 710 nM 0.680711731366421 0.243016817086838 no 842 0.248026955888076 289 3818134 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.67733066795107 0.244114227741305 no 843 0.249098088490127 269 97141 SGTC_1945 st075991 56.6 µM 0.676361165125271 0.244429397016512 no 844 0.249405683691589 262 1084980 SGTC_2836 9010338 19.48 µM 0.675913088569771 0.244575133315228 no 845 0.24954791360485 261 2994051 SGTC_3218 9131285 49.47 µM 0.674650708627891 0.244985972243232 no 846 0.249948853957796 286 17156417 SGTC_2101 5377231 179.231 µM 0.674630321522862 0.24499261022942 no 847 0.24995533184332 290 2844213 SGTC_188 3229-0966 278.469 µM 0.674483122802029 0.245040540605721 no 848 0.250002106035275 278 5722370 SGTC_307 1501-1223 22.3 µM 0.673288753824674 0.245429633654146 no 849 0.250381803039704 278 2830329 SGTC_889 0919-1524 82.7 µM 0.672888381963998 0.245560138217278 no 850 0.250509152010534 281 3905452 SGTC_2129 girgensonine 121.053 µM 0.672088251923108 0.245821058957197 no 851 0.25076375755156 282 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1126 isoteolin 1.0172 µM 0.671993053062888 0.245852113010845 no 852 0.250794059442461 274 133323 SGTC_824 1304-0008 100 µM 0.671390427377312 0.246048739526162 no 853 0.25098592076103 276 768245 SGTC_1284 0929-0043 16 µM 0.670509173904228 0.246336429369557 no 854 0.251266630148737 274 1239883 SGTC_2575 plumbagin 510 nM 0.668599547541788 0.246960455155391 no 855 0.251875480642014 280 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3020 9089140 49.47 µM 0.667666506769797 0.247265660627436 no 856 0.252173247098297 277 17217859 SGTC_1552 6-methylflavone 10.6 µM 0.667619480499432 0.247281048651923 no 857 0.252188259764717 287 689013 SGTC_782 0083-0095 30.5 µM 0.667033613264836 0.247472800143488 no 858 0.252375331527336 279 3591729 An indicator and reagent. SGTC_234 nsc-17383 10.7 µM 0.666790436712584 0.247552413972208 no 859 0.252453001083878 269 408974 SGTC_2847 9005661 71.43 µM 0.666109286630758 0.247775489240994 no 860 0.252670624563825 260 2991449 SGTC_143 4032-1194 15.74 µM 0.662733616054981 0.248882596614486 no 861 0.253750588083844 282 1806963 SGTC_298 1391-0729 10 µM 0.660641914802657 0.249569923853221 no 862 0.254420991084464 286 3237558 SGTC_2531 methyl deoxycholate 70.07 µM 0.660269725774186 0.249692329733243 no 863 0.254540377137397 292 16667744 Haematoxylin. SGTC_3325 9138760 55.175 µM 0.658401516810456 0.250307229448865 no 864 0.255140080496414 267 43844959 SGTC_1089 terbinafine 2.25 µM 0.656401990700549 0.250966239110249 no 865 0.255782754964587 294 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_790 1575-0012 79.1 µM 0.656196168741044 0.251034126596644 no 866 0.255848956836926 295 378741 YLR208W SEC13 SGTC_2054 5233173 129 µM 0.655978910713118 0.251105796649555 no 867 0.255918846779214 232 6889 SGTC_2894 9048625 32.47 µM 0.655759143567775 0.251178305432268 no 868 0.255989554016289 300 4092861 SGTC_2938 9059746 27.26 µM 0.655685552503728 0.251202588144368 no 869 0.256013233267155 290 6471769 SGTC_426 0988-0037 14.6 µM 0.65518633344232 0.251367347338732 no 870 0.256173896157887 287 5383008 SGTC_1665 st014639 11.4 µM 0.654764185357507 0.251506715063458 no 871 0.25630979643112 285 981133 YIL048W NEO1 SGTC_3068 9116768 49.47 µM 0.6529915271914 0.252092384814859 no 872 0.25688087040582 286 41904888 SGTC_3220 9131269 49.47 µM 0.651890404736556 0.252456547345353 no 873 0.257235937646804 292 17722206 SGTC_3173 9105693 49.47 µM 0.650502456897023 0.252915963234739 no 874 0.257683857620172 307 17096658 SGTC_1931 st074438 57.1 µM 0.64912755094409 0.253371495667331 no 875 0.258127967612191 309 2787313 SGTC_1135 dihydrocapsaicin 536.708 nM 0.64843741161892 0.253600314381752 no 876 0.258351039837435 311 107982 A Capsaicinoid. SGTC_2220 6782180 200 µM 0.647018136325622 0.254071222250098 no 877 0.258810102833502 272 833803 SGTC_2330 7979373 200 µM 0.646156362253842 0.254357377888209 no 878 0.25908904850915 275 1863007 SGTC_1913 st060213 96.1 µM 0.645266093302031 0.254653172674729 no 879 0.259377380788499 303 688959 SGTC_1610 st001799 48.1 µM 0.644994856540956 0.254743327770973 no 880 0.259465259439483 291 621897 SGTC_246 cycloheximide 667 µM 0.64440338655597 0.254939981603338 no 881 0.259656944538799 284 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2263 7948595 193.29 µM 0.644398301076872 0.254941672784079 no 882 0.259658592970722 292 2971371 SGTC_2756 carbadox 75.1 µM 0.643712280355716 0.255169863404029 no 883 0.259881012568857 287 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2924 9010168 62.78 µM 0.64330234868303 0.255306269669247 no 884 0.260013966292428 288 2993929 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.642516190932722 0.255567973146305 no 885 0.260269040052754 289 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2868 9035608 32.47 µM 0.642411349834633 0.255602884209062 no 886 0.260303066138925 283 6462614 SGTC_329 k048-0121 21.3 µM 0.642381927179117 0.255612682113853 no 887 0.260312615647734 280 6832902 SGTC_378 3970-0959 8.33 µM 0.64226127065225 0.255652863446954 no 888 0.260351778193949 303 6615653 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.641734767000984 0.255828239580502 no 889 0.26052270560993 295 688761 SGTC_2863 9028737 58.44 µM 0.641199881721962 0.256006471879994 no 890 0.260696413238061 300 6460917 SGTC_2891 9063876 19.48 µM 0.640066635442009 0.256384301504693 no 891 0.261064639487101 281 6472478 SGTC_2896 9052656 71.43 µM 0.639415646822044 0.256601475500359 no 892 0.261276286373069 291 6469436 SGTC_335 4077-0256 27.6 µM 0.638462722148748 0.256919549987336 no 893 0.261586256417685 296 3121989 SGTC_1460 k062-0059 9.15 µM 0.637500225766173 0.257241027519116 no 894 0.261899531471597 280 1373085 SGTC_910 3454-3003 490 µM 0.634896236811018 0.258111816946792 no 895 0.262748045795266 303 820824 SGTC_1096 rimcazole 32.2 µM 0.634399374759725 0.258278144055769 no 896 0.262910108765805 304 18528119 A dopamine reuptake inhibitor. SGTC_3305 9127027 53.8275 µM 0.632582659460124 0.258886771321165 no 897 0.263503106939451 295 41905295 SGTC_2970 9090938 41.86 µM 0.631840352616917 0.259135668768712 no 898 0.26374560129932 287 17217104 SGTC_1378 2093-0007 380 nM 0.628481314893191 0.260263507540499 no 899 0.264844341648324 313 3618014 SGTC_551 k048-0028 34.9 µM 0.625849687889344 0.261148872858305 no 900 0.265706768706594 298 6836383 SGTC_643 k048-0106 28.4 µM 0.623994095850059 0.261774083879934 no 901 0.266315731259691 298 6763920 SGTC_2642 cholecalciferol 100 µM 0.622504598691316 0.262276500273474 no 902 0.266805060423895 295 9821465 A vitamin D precursor, similar to steriods. SGTC_694 1315-0438 43.2 µM 0.622377946202458 0.262319243697544 no 903 0.266846689210985 293 6793154 SGTC_1295 1013-0063 9.78 µM 0.62227556032858 0.262353800089878 no 904 0.266880344321771 302 6826038 SGTC_2160 5660466 132.927 µM 0.619369167643172 0.263335711972449 no 905 0.267836593963864 306 2859134 SGTC_468 gf-109203x 121 µM 0.618366173669891 0.263675004055428 no 906 0.268166995147241 273 2396 A protein kinase C inhibitor. SGTC_1438 4092-1045 4 µM 0.618062611230524 0.263777736881728 no 907 0.268267033562747 305 1351342 SGTC_3126 9127922 49.47 µM 0.612515815605631 0.265658492960499 no 908 0.270098268664565 330 45595682 SGTC_794 k038-0031 316 µM 0.611500151260486 0.266003610118573 no 909 0.27043425912185 297 6624242 SGTC_1119 parthenolide 318.541 nM 0.61078677280238 0.266246147900568 no 910 0.270670375630586 326 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2296 7971656 126.45 µM 0.609593180917597 0.266652201089582 no 911 0.271065664952013 293 666570 SGTC_1149 3909-7961 23.3 µM 0.609341500313241 0.266737861354537 no 912 0.271149052340945 288 735261 SGTC_2288 7946289 167.31 µM 0.608648472009239 0.266973807517266 no 913 0.271378734135414 311 1246052 SGTC_1826 st055655 41.6 µM 0.608384077762023 0.267063850093762 no 914 0.271466384589009 302 676168 SGTC_1746 st038117 42 µM 0.606922696682158 0.267561817095824 no 915 0.271951107448488 288 2898218 SGTC_1821 st053465 65.6 µM 0.606568405964469 0.267682612460599 no 916 0.272068686301031 287 675086 SGTC_1212 0520-0165 585 µM 0.606493481499875 0.267708161465424 no 917 0.272093554803485 341 5403258 SGTC_1968 st069590 43.6 µM 0.606160198414107 0.267821824829806 no 918 0.272204189923743 303 6384066 SGTC_3033 9090887 49.47 µM 0.602884828291866 0.268940153873554 no 919 0.273292654791892 296 19325384 SGTC_1090 efavirenz 20.7 µM 0.602437535091341 0.269093057586999 no 920 0.273441465565149 307 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_633 0437-0093 97.7 µM 0.602055498069956 0.269223688513846 no 921 0.273568597899674 307 2831118 SGTC_57 miconazole 162.5 nM 0.60131114584547 0.269478298166107 no 922 0.273816383630702 300 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_290 2043-6722 48.1 µM 0.601073081019659 0.269559754975507 no 923 0.273895655910044 301 773758 YLR208W SEC13 SGTC_2525 harmine 47.85 µM 0.599506729322255 0.270096008940744 no 924 0.274417511995175 290 5280953 A monoamine oxidase inhibitor SGTC_2152 5568786 200 µM 0.599448253209545 0.270116039069597 no 925 0.27443700378177 312 5399883 SGTC_1209 2323-2347 50.3 µM 0.599275594957295 0.270175184939795 no 926 0.274494559778393 295 5412760 SGTC_2488 5268135 45.7 µM 0.594449755423506 0.271830942188073 no 927 0.276105669213638 317 1270356 YLR208W SEC13 SGTC_2629 bisabolol 100 µM 0.593535139267647 0.272145317403428 no 928 0.276411536837304 334 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1999 st074831 12.5 µM 0.593104324504669 0.272293461221642 no 929 0.276555668257425 321 17112523 SGTC_2462 5162487 171.77 µM 0.591213145163571 0.272944252696431 no 930 0.27718880808213 323 2259986 SGTC_2746 daunorubicin 9.88 µM 0.590877653164443 0.273059782491701 no 931 0.277301200023661 281 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1171 0368-0077 21.4 µM 0.590694315075492 0.27312292691116 no 932 0.277362628858968 319 3239779 SGTC_451 chloral hydrate 100 µM 0.589671590304367 0.273475301557955 no 933 0.277705422682339 327 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2431 5490079 200 µM 0.589622936656454 0.273492070532376 no 934 0.277721735420872 340 5722345 SGTC_1020 4335-0961 93.3 µM 0.589306978372823 0.273600981150781 no 935 0.277827682232073 337 669075 SGTC_1499 4480-0877 67.3 µM 0.586749412525894 0.274483361617454 no 936 0.278686008208519 302 2861909 SGTC_2523 spermine 47.74 µM 0.584560901352037 0.27523952855486 no 937 0.279421502013094 280 1103 A DNA binding polyamine. SGTC_3188 9110789 49.47 µM 0.582582702217979 0.275923910428073 no 938 0.280087126392743 316 849217 SGTC_2763 lisinopril 49.32 µM 0.581022765716545 0.27646417811331 no 939 0.280612555136615 312 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3292 9120825 59.784 µM 0.580247417687754 0.276732904646668 no 940 0.280873890602858 315 24824900 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.577524698902087 0.277677579552385 no 941 0.281792529340035 271 4000243 SGTC_2261 9010538 184.68 µM 0.57702490489211 0.277851159114319 no 942 0.281961315804966 343 6457250 SGTC_1550 gossypolone 36.6 µM 0.57629526169674 0.278104660881007 no 943 0.282207812520095 307 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2335 9018011 154.17 µM 0.575713909413849 0.278306722285835 no 944 0.282404286052693 311 6458208 SGTC_3261 9137475 49.47 µM 0.575624948566548 0.278337648841113 no 945 0.282434357020326 271 17027690 SGTC_192 3455-0609 60.9 µM 0.574469443766367 0.278739503323355 no 946 0.282825086078741 294 3769639 SGTC_270 tamoxifen 5.46 µM 0.572657848738501 0.279370096833193 no 947 0.28343819138771 334 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_583 1488-1091 88.9 µM 0.571735767253561 0.279691327761995 no 948 0.283750499564846 326 4303273 SGTC_182 3448-4371 550.524 µM 0.571290851778833 0.279846389657295 no 949 0.283901250953841 288 3491403 SGTC_1082 camptothecin 424.86 nM 0.570317140758054 0.280185892737642 no 950 0.284231308626709 314 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2246 7293507 91.5585 µM 0.568883864003162 0.280685995023958 no 951 0.284717478249802 307 887656 SGTC_1611 st001856 99.4 µM 0.568439391185325 0.280841169186691 no 952 0.284868324685732 348 647478 SGTC_306 1672-3436 11.6 µM 0.566131239274389 0.281647656457968 no 953 0.285652284252931 332 6797378 SGTC_3132 9126706 49.47 µM 0.565632850725569 0.281821944007267 no 954 0.285821695675016 341 850858 SGTC_3139 9095020 49.47 µM 0.562788456925812 0.28281762818936 no 955 0.286789470705998 280 25236292 SGTC_2750 bromebric acid 70.15 µM 0.56196902571791 0.283104784466718 no 956 0.287068561449368 312 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2332 7982454 138.89 µM 0.561844485025501 0.283148439962773 no 957 0.287110990121984 337 2981748 SGTC_2477 5967686 25.23 µM 0.56177237039742 0.28317371992303 no 958 0.287135559577399 322 776118 SGTC_1104 tacrolimus 29.8 µM 0.561458766376858 0.283283667175589 no 959 0.287242416049281 323 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2941 9056145 11.23 µM 0.559740318441747 0.283886505516515 no 960 0.287828288589683 317 2119517 SGTC_567 1080-0542 68.4 µM 0.559066953486155 0.284122891936293 no 961 0.288058013535201 297 5950415 SGTC_2265 7929201 200 µM 0.55869344505602 0.284254053565353 no 962 0.288185476837643 338 1265108 SGTC_2626 ethyl orsellinate 100 µM 0.557689297663364 0.284606814503556 no 963 0.288528283536888 329 75653 A natural product. SGTC_2255 7941087 197.44 µM 0.557481362880027 0.284679888929133 no 964 0.288599294569522 323 935561 SGTC_337 1315-0038 354 µM 0.556746562004429 0.28493819138821 no 965 0.288850299608028 325 1626437 SGTC_1956 st077085 54 µM 0.555318665880915 0.285440455075539 no 966 0.289338356837185 339 24208685 SGTC_1997 st073024 93.8 µM 0.554711987695447 0.28565398218005 no 967 0.28954583766264 314 686268 SGTC_1565 sinapyl alcohol 95.1 µM 0.554292614525848 0.285801629623981 no 968 0.289689301959787 327 5280507 A phenol propionate derived from cinnamic acid. SGTC_609 0986-0026 86.3 µM 0.553239698120289 0.286172486586573 no 969 0.290049643418693 307 2848610 SGTC_2008 4012253 172 µM 0.54973932168317 0.287407025263896 no 970 0.291249091223169 314 603940 SGTC_2036 5160441 105 µM 0.548579115088685 0.28781677066098 no 971 0.291647160825805 324 134534 YIL048W NEO1 SGTC_1140 3229-1848 2.98 µM 0.548276107671511 0.28792382796963 no 972 0.291751165134287 326 2849525 SGTC_2831 7999036 19.48 µM 0.548224419404382 0.287942092128311 no 973 0.291768908347797 334 2988270 SGTC_1451 4152-0210 104 µM 0.54739738719018 0.28823440008338 no 974 0.292052874969293 344 659563 SGTC_490 phenamil 164 µM 0.542339116824358 0.290025244264018 no 975 0.293792456545936 327 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_70 0141-0289 43.283 µM 0.541420551670694 0.290351014418176 no 976 0.294108872418756 313 352408 SGTC_1076 itraconazole 331 nM 0.537895094285798 0.291602909850655 no 977 0.295324737712482 318 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1428 4049-0204 61.7 µM 0.537869548731104 0.291611990293867 no 978 0.29533355633859 338 X1428 SGTC_491 tetrandrine 80.3 µM 0.537237319422858 0.291836765020335 no 979 0.295551847934638 342 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1893 st059353 36.1 µM 0.536916798569018 0.291950749730486 no 980 0.295662543405021 359 3112488 SGTC_2221 6807166 181.081 µM 0.536839973044762 0.291978073763034 no 981 0.295689078791951 312 674925 SGTC_2919 7978188 46.38 µM 0.536800352734175 0.291992165725555 no 982 0.295702763998063 299 2980291 SGTC_2459 5811157 9.22 µM 0.535654349057344 0.292399907808272 no 983 0.296098729720322 329 2870684 YBR192W RIM2 SGTC_3232 9132874 49.47 µM 0.535381646214832 0.292496973023711 no 984 0.296192989484067 309 3784940 SGTC_427 1354-0053 47.3 µM 0.535148001338004 0.292580147948014 no 985 0.296273759805705 337 6813657 SGTC_1643 st009866 20.2 µM 0.534468490512134 0.292822108525022 no 986 0.296508722014761 300 3156273 YOR207C RET1 SGTC_897 1000-0139 31.4 µM 0.534261776906769 0.292895733639878 no 987 0.296580216670627 333 6151020 SGTC_3064 1327-0027 10 µM 0.533340748685214 0.293223880327201 no 988 0.296898862497538 322 16000455 YPR107C YTH1 SGTC_1663 st014140 55.4 µM 0.532496053235666 0.293524980695538 no 989 0.297191237309605 330 4207120 SGTC_1688 st021091 57.6 µM 0.529540310003419 0.294579711168588 no 990 0.298215344487329 345 3656366 SGTC_2253 7938677 135.83 µM 0.529417860320204 0.294623443937412 no 991 0.298257805555449 313 2301972 SGTC_2556 citropten 84.59 µM 0.527738291856984 0.295223602003848 no 992 0.298840496051082 286 2775 A potential DNA crosslinker. SGTC_2886 9058944 51.95 µM 0.527707047519787 0.295234771833252 no 993 0.298851340507376 298 4949929 SGTC_1797 st048695 56.8 µM 0.5267552652927 0.295575126517934 no 994 0.299181775963615 344 592262 YIL048W NEO1 SGTC_2345 9052315 157.45 µM 0.526112534203748 0.295805067364951 no 995 0.299405010187724 319 6469265 SGTC_2258 7960471 200 µM 0.523639072793787 0.296690728456003 no 996 0.300264799872465 341 2974708 SGTC_1839 st053978 48 µM 0.522828713003847 0.296981154163981 no 997 0.30054672821319 338 3788398 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.522447666448337 0.297117762783091 no 998 0.300679337575951 338 689007 SGTC_629 3448-6466 76.7 µM 0.521989743232034 0.297281970377098 no 999 0.300838735986153 345 573744 SGTC_1490 4089-0339 670 nM 0.521136468841194 0.297588058308961 no 1000 0.30113585375286 345 742542 SGTC_954 1189-0853 2.85 µM 0.519913380639702 0.298027057132366 no 1001 0.301561974425287 317 2828194 SGTC_2326 6164455 177.58 µM 0.519032392275912 0.298343449978716 no 1002 0.301869076388813 355 2888790 SGTC_1924 st058459 75.1 µM 0.51854058494594 0.298520141172342 no 1003 0.302040575619892 335 688683 SGTC_1508 1080-0625 72.9 µM 0.518529018699452 0.298524297140584 no 1004 0.302044609438075 325 767111 SGTC_353 1988-1175 58.3 µM 0.518099137462144 0.298678780157293 no 1005 0.302194551009987 345 2788357 SGTC_1907 st060210 83.7 µM 0.515353041222556 0.299666479527549 no 1006 0.303153170236779 350 688793 SGTC_232 clozapine 119 µM 0.513095842357005 0.300479441460277 no 1007 0.303942139849054 340 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_279 1273-0055 2.93 µM 0.512839267817461 0.300571913409656 no 1008 0.304031879510991 347 2847562 SGTC_3010 9080089 71.4286 µM 0.511243388349045 0.301147372113156 no 1009 0.304590320236774 335 17027233 SGTC_86 0417-1630 471.922 µM 0.511111184001636 0.301195065979507 no 1010 0.304636602516905 331 3634867 SGTC_990 3985-0011 41.3 µM 0.510843065109777 0.301291802644709 no 1011 0.304730475550438 355 5399565 YGL099W LSG1 SGTC_1657 st012939 43.4 µM 0.509494612677017 0.301778533093565 no 1012 0.305202786781645 316 24207257 SGTC_3155 9099265 49.47 µM 0.509328347894757 0.301838571643306 no 1013 0.305261045457859 356 25236499 SGTC_3277 9138724 49.47 µM 0.509144706846031 0.301904891036307 no 1014 0.305325398459306 320 15943418 SGTC_1816 st051957 91.6 µM 0.507580916238874 0.302469897156684 no 1015 0.305873638404004 332 674121 SGTC_934 2950-0684 338 µM 0.506912284631421 0.302711622028968 no 1016 0.306108182858912 365 1121253 SGTC_1976 st070609 63.5 µM 0.506857343500153 0.302731488290145 no 1017 0.306127458797845 339 682556 SGTC_2764 methyldopa 94.69 µM 0.505010494776819 0.303399633055728 no 1018 0.306775732423245 352 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2670 beta-carotene 100 µM 0.504200907541246 0.303692729521518 no 1019 0.307060101375217 321 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_760 0568-0725 82.9 µM 0.503350845962263 0.304000614927587 no 1020 0.307358811962776 337 3916171 SGTC_589 1227-0070 34.1 µM 0.50326551962314 0.304031527118762 no 1021 0.307388802595554 336 2841384 SGTC_3164 9100705 49.47 µM 0.502338753409313 0.304367367989457 no 1022 0.307714626733955 337 17174235 SGTC_454 lyso-paf C-16 6.67 µM 0.501660225164821 0.304613357239046 no 1023 0.307953273815671 354 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_755 1995-0008 37.3 µM 0.501220230252946 0.304772917400552 no 1024 0.30810806909613 330 689533 SGTC_1369 1866-0067 208 µM 0.499342490837912 0.305454279739616 no 1025 0.308769062942545 345 3531355 SGTC_2056 5235370 200 µM 0.498554518002596 0.305740407039289 no 1026 0.309046626587658 325 5511916 SGTC_2914 7968218 45.32 µM 0.49449416762873 0.307216671996875 no 1027 0.31047861217901 344 2977111 SGTC_1408 3909-7976 48.8 µM 0.494423173205952 0.307242512104193 no 1028 0.310503675816741 339 24152374 SGTC_3315 9136395 68.55 µM 0.491436026161778 0.308330621276269 no 1029 0.311559044486915 383 16876844 SGTC_2262 9014885 67.46 µM 0.491374260243298 0.308353138181153 no 1030 0.311580882969958 344 6457424 SGTC_2520 obtusaquinone 4.71 µM 0.491291291075148 0.308383385913286 no 1031 0.3116102192973 367 5967872 SGTC_3006 9075424 71.4286 µM 0.490794236523543 0.308564622303779 no 1032 0.311785993413999 335 7465181 SGTC_2913 7966556 36.57 µM 0.490618596531014 0.308628675441868 no 1033 0.311848115493631 337 2976516 SGTC_383 2324-0395 7.37 µM 0.4898972361321 0.308891805270809 no 1034 0.312103309460464 340 3146421 SGTC_1731 st035964 63 µM 0.489190996095247 0.309149514719055 no 1035 0.312353241716537 352 6739575 SGTC_2799 7812892 81.82 µM 0.488176911914641 0.309519721836756 no 1036 0.312712268370151 351 20205235 SGTC_2269 7935389 174.42 µM 0.487897345888596 0.309621815758334 no 1037 0.312811277279406 355 97605 SGTC_2272 7805186 180 µM 0.487395968045195 0.309804949302075 no 1038 0.312988875146889 373 2956062 YPR165W RHO1 SGTC_3238 9133470 49.47 µM 0.486871155090091 0.309996693343872 no 1039 0.313174820685516 337 3534688 SGTC_1774 st048371 48.465 µM 0.483856439860481 0.311099140362037 no 1040 0.314243878318822 342 4242727 SGTC_1802 st050112 57.9 µM 0.482128000001806 0.311731977265537 no 1041 0.31485751013104 340 4662563 SGTC_2748 diazoxide 86.69 µM 0.481790217480698 0.311855715255792 no 1042 0.31497748969544 331 3019 A potassium channel activatior. SGTC_2833 9001315 45.46 µM 0.481035749923807 0.312132171842119 no 1043 0.315245545315346 327 2989378 SGTC_2545 solidagenone 89.61 µM 0.477175211288034 0.31354842744496 no 1044 0.316618680627699 335 6708572 An anti ulcer agent SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.476315325058002 0.313864256112268 no 1045 0.316924874511182 334 688664 SGTC_3266 9136860 49.47 µM 0.476172061296129 0.313916888899094 no 1046 0.316975900998567 355 4871271 YPR165W RHO1 SGTC_987 1497-1013 404 µM 0.475053015880076 0.314328138291986 no 1047 0.31737459295383 353 1676435 SGTC_1710 st031758 61.5 µM 0.474884113745325 0.314390229895738 no 1048 0.317434787596729 353 5394341 SGTC_1196 1588-0294 184 µM 0.474746623342856 0.314440777832946 no 1049 0.317483791049656 364 6144269 SGTC_3233 9132340 49.47 µM 0.474418886973117 0.314561283163017 no 1050 0.317600613656334 377 17682950 SGTC_1800 st050079 29.0735 µM 0.473355242373485 0.314952510523301 no 1051 0.31797987804087 349 3645560 SGTC_2939 9044578 71.43 µM 0.471431030350359 0.315660797452808 no 1052 0.318666480548727 363 2653634 SGTC_1693 xanthone 101.9 µM 0.469149392571743 0.316501527986239 no 1053 0.319481428008309 373 7020 An insecticide. SGTC_442 cape 100 µM 0.468860009475546 0.316608226844673 no 1054 0.319584851296599 353 5281787 SGTC_1318 1280-3875 124 µM 0.467897938146527 0.316963063226084 no 1055 0.319928789018377 350 373245 SGTC_610 4215-0184 155 µM 0.467273187590477 0.317193577337052 no 1056 0.320152218486312 329 5605015 SGTC_109 0132-0036 33.701 µM 0.46625698627677 0.317568676490802 no 1057 0.320515781764411 341 67274 A color developer. SGTC_1009 4106-0057 9.87 µM 0.466225177353728 0.317580420793047 no 1058 0.320527164729448 347 2928005 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.465103829264205 0.31799455553827 no 1059 0.320928551951652 366 368090 SGTC_1779 st039427 55 µM 0.465024405484531 0.318023896861134 no 1060 0.320956989686797 372 1124498 SGTC_111 0083-0039 52.457 µM 0.463574023347105 0.318559908541387 no 1061 0.321476484518313 379 759313 SGTC_2645 abamectin 100 µM 0.463046468802752 0.318754968966882 no 1062 0.321665529602494 328 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_542 3381-0244 89.3 µM 0.461517489884139 0.319320584184329 no 1063 0.322213688110949 375 1112843 SGTC_1946 st076057 65.1 µM 0.460108424711781 0.319842212316596 no 1064 0.322719198644431 360 953009 SGTC_1569 carminic acid 40.6 µM 0.455040026594677 0.321721446559484 no 1065 0.324540221494937 347 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2528 xanthyletin 44.79 µM 0.454671533741717 0.3218582531985 no 1066 0.324672781563246 369 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2214 7179297 48.276 µM 0.454145496637143 0.322053591553014 no 1067 0.324862054419829 350 769744 SGTC_1603 st002045 67.8 µM 0.453848544187986 0.322163883443565 no 1068 0.324968920540113 377 5887985 SGTC_1363 1636-0063 10.4 µM 0.453435650860411 0.322317263266764 no 1069 0.325117534958787 355 6072185 SGTC_2543 pimpinellin 60.67 µM 0.45223844401566 0.322762167452012 no 1070 0.325548607858564 363 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2718 lomofungin 53.02 µM 0.451991233599239 0.322854067047934 no 1071 0.325637648900907 358 5351222 A RNA synthesis inhibitor. SGTC_1144 3486-0183 12.5 µM 0.450944116990582 0.32324344884034 no 1072 0.326014913003002 388 6744069 SGTC_2504 purpurogallin 52.29 µM 0.448667623177961 0.324090655991829 no 1073 0.326835721946971 364 5281571 An antioxidant. SGTC_2996 9066192 71.4286 µM 0.448093149473882 0.324304593153805 no 1074 0.327042985936979 335 6472854 SGTC_2705 st078069 42.8 µM 0.448013781396411 0.32433415482441 no 1075 0.327071625290037 351 1530061 SGTC_1729 st035615 45.989 µM 0.447485609764204 0.32453090739757 no 1076 0.32726223784398 343 17385451 SGTC_2389 9091542 195.52 µM 0.447081566141202 0.324681453330065 no 1077 0.327408084097269 348 3626624 YOL127W RPL25 SGTC_1640 st009078 66.4 µM 0.446984593376706 0.324717589472467 no 1078 0.327443091947896 374 690618 SGTC_172 1112-0046 2.638 µM 0.445940223214651 0.325106870350224 no 1079 0.327820213048019 339 2802135 YIL048W NEO1 SGTC_663 1486-0733 13.9 µM 0.44575151287516 0.325177231050044 no 1080 0.327888374926412 363 722445 YPR165W RHO1 SGTC_1257 0669-0121 16 µM 0.445334086172285 0.325332890848846 no 1081 0.328039169162826 361 4307855 SGTC_1928 4'-methoxychalcone 40.3 µM 0.445185410688417 0.325388339791056 no 1082 0.328092884540029 394 641818 SGTC_2116 5511452 16.8835 µM 0.444414786567083 0.325675808156086 no 1083 0.328371362416152 378 870744 SGTC_894 0960-0238 55.9 µM 0.442933159971071 0.326228795272375 no 1084 0.328907040778471 369 6741907 YDL195W SEC31 SGTC_534 k292-0788 63.4 µM 0.442186546155293 0.32650759868604 no 1085 0.329177110433572 386 4146317 SGTC_536 3852-0578 10.6 µM 0.439859624984001 0.327377147883264 no 1086 0.330019389920274 363 2869208 SGTC_958 1222-0007 33 µM 0.437619606720784 0.328215108073666 no 1087 0.330831027873847 377 7312461 SGTC_1987 st072290 61.9 µM 0.437249233604629 0.3283537430511 no 1088 0.330965303949391 376 54697379 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.436169005345643 0.32875822004832 no 1089 0.331357056992279 363 688667 SGTC_750 4073-0104 132 µM 0.436164629010895 0.328759859116667 no 1090 0.331358644479305 340 22330957 SGTC_199 4063-0024 41.6 µM 0.436089405800226 0.328788032975363 no 1091 0.331385931684408 368 306215 SGTC_2667 digitoxin 100 µM 0.435031278882392 0.32918444346267 no 1092 0.331769861816538 341 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3178 9107506 49.47 µM 0.434178018836364 0.329504243784292 no 1093 0.332079586939294 367 8897194 SGTC_709 3807-1509 243 µM 0.433617168561231 0.329714517410126 no 1094 0.332283232671203 385 1886677 YPL242C IQG1 SGTC_1493 4348-0038 111 µM 0.433106535384458 0.329906010498169 no 1095 0.332468687564443 386 800424 SGTC_2466 5983409 37.09 µM 0.43241595996727 0.330165054829112 no 1096 0.332719560227 369 2879657 SGTC_34 0469-0683 81.75 µM 0.432229553708562 0.330234992341469 no 1097 0.332787290853356 354 3690923 SGTC_2048 5246248 200 µM 0.432171645634558 0.330256720001178 no 1098 0.332808332835878 343 677046 SGTC_875 0709-0210 25.7 µM 0.431208596425806 0.330618149081708 no 1099 0.333158351950073 366 6251364 SGTC_752 1896-0090 130 µM 0.430645419402125 0.330829580736558 no 1100 0.333363105369062 364 772567 SGTC_813 k007-0158 173 µM 0.430195893695683 0.330998383401335 no 1101 0.333526574395295 368 6523916 SGTC_1935 st074532 41.6 µM 0.428090120162618 0.331789585367143 no 1102 0.334292754762705 401 2829742 SGTC_3016 9080866 49.47 µM 0.427622049474601 0.331965555618438 no 1103 0.334463155062195 372 17066299 SGTC_413 propylparaben 100 µM 0.427127303424887 0.332151594718959 no 1104 0.33464330356052 346 7175 A pharmaceutical preservative. SGTC_2916 7875993 68.79 µM 0.426543981766347 0.332370994008868 no 1105 0.33485575339478 385 1299250 SGTC_446 go6976 132 µM 0.425441459718811 0.332785832126521 no 1106 0.335257443991011 400 3501 A protein kinase C inhibitor. SGTC_895 0964-0006 13.7 µM 0.425194588812083 0.332878748563952 no 1107 0.335347414263403 372 6738897 SGTC_2697 mebhydrolin 72.4 µM 0.423397535200559 0.333555426502916 no 1108 0.336002621451017 359 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1360 1598-0022 39.8 µM 0.422944567066502 0.333726076593021 no 1109 0.336167852760738 392 761525 SGTC_1850 st056238 17 µM 0.420573000738902 0.334620095466558 no 1110 0.337033456260968 370 5393177 SGTC_1337 1486-1011 40.3 µM 0.420204661842017 0.334759033981355 no 1111 0.337167974730189 360 X1337 SGTC_733 4069-0007 56.1 µM 0.420011614778216 0.334831860938838 no 1112 0.337238484413664 365 5717425 YNL287W SEC21 SGTC_2866 9034245 58.44 µM 0.41922119945499 0.335130109691649 no 1113 0.337527240117073 395 6462273 SGTC_718 1130-0073 349 µM 0.418604891571477 0.335362734346433 no 1114 0.337752457038605 379 6740020 SGTC_2284 7945075 39.21 µM 0.418352723732857 0.335457932994994 no 1115 0.337844623296806 394 1245402 SGTC_1043 0916-0009 19.3 µM 0.418309746358131 0.335474158909365 no 1116 0.337860332311999 392 3101130 SGTC_407 eburnamonine 100 µM 0.418217354405503 0.335509042114089 no 1117 0.337894104213824 349 3195 SGTC_3319 9138450 16.7555 µM 0.417837344364358 0.335652532374102 no 1118 0.338033022474275 376 2029690 SGTC_2797 7859098 81.82 µM 0.417613013149507 0.335737250188991 no 1119 0.338115040405764 351 972681 SGTC_3166 9102297 49.47 µM 0.416959616455567 0.335984050480939 no 1120 0.338353973114102 374 25237072 SGTC_1960 st011366 51.8 µM 0.415792361661412 0.336425120693883 no 1121 0.338780974337703 360 3972846 SGTC_1163 k060-0048 49.9 µM 0.413388904004746 0.337334023216271 no 1122 0.339660851439679 356 6809982 SGTC_3329 9141233 27.5565 µM 0.411725969802116 0.337963442460061 no 1123 0.340270143949905 365 4909101 YNL103W MET4 SGTC_439 amiodarone 34.4 µM 0.411435479176869 0.338073439482932 no 1124 0.340376621420831 390 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3001 9076041 71.4286 µM 0.410182678961023 0.338547982419412 no 1125 0.340835972988835 356 16004211 SGTC_1440 4100-1550 40 µM 0.408553109446729 0.339165623915613 no 1126 0.341433823950886 386 742806 SGTC_3084 9116877 49.47 µM 0.407041438375305 0.33973896613046 no 1127 0.341988776751854 378 27241325 SGTC_93 0109-0045 59.227 µM 0.406276157427691 0.34002936119952 no 1128 0.342269850975534 359 88733 SGTC_1969 st069479 40.1 µM 0.40457994237364 0.340673348617356 no 1129 0.342893152272019 400 3895485 SGTC_2958 9077254 16.72 µM 0.404435280576449 0.34072829265245 no 1130 0.342946330382103 350 16457351 SGTC_2292 7671323 168.05 µM 0.403617335709121 0.341039020049232 no 1131 0.343247067869586 403 937504 SGTC_213 1246-0773 967 nM 0.401716793456538 0.341761429269457 no 1132 0.34394623196969 382 6251622 SGTC_1864 st057645 30.4 µM 0.399803361781785 0.342489323706352 no 1133 0.344650677221445 379 688666 SGTC_1464 k208-0027 110 µM 0.397635365070917 0.343314765358221 no 1134 0.345449493980917 408 X1464 SGTC_2771 fluoxetine 41.05 µM 0.396759252976767 0.343648548149094 no 1135 0.345772500540983 403 3386 A selective serotonin reuptake inhibitor. SGTC_2215 7188065 200 µM 0.396742988010946 0.343654745959225 no 1136 0.345778498199822 395 940217 SGTC_623 k072-0108 16.9 µM 0.395118735129295 0.344273883412101 no 1137 0.346377631418047 395 5382803 SGTC_2084 5306078 60.6385 µM 0.394645351586692 0.344454407794763 no 1138 0.346552319409567 405 679340 SGTC_501 nsc-95397 161 µM 0.393519339884842 0.344883953666081 no 1139 0.346967971328061 397 262093 SGTC_922 1866-0035 480 µM 0.39276523129918 0.345171739475956 no 1140 0.347246443292735 384 3156169 SGTC_847 0342-0274 5.54 µM 0.392608064144896 0.345231729491342 no 1141 0.347304491276814 399 18097 SGTC_3076 9116187 49.47 µM 0.389661594414092 0.346357102516204 no 1142 0.348393399631978 402 27241210 SGTC_2219 9098279 200 µM 0.3876495319702 0.347126369384107 no 1143 0.349137704199981 374 902349 SGTC_2308 7584454 197.62 µM 0.387645007281553 0.347128100008667 no 1144 0.349139378633703 393 893577 SGTC_2483 5729050 27.16 µM 0.387097694627083 0.347337462278292 no 1145 0.349341942128901 410 2865180 SGTC_189 3970-0742 2.116 µM 0.386583287501691 0.347534279744764 no 1146 0.349532366230683 407 2891807 SGTC_349 k015-0014 24 µM 0.385236232590452 0.348049871490249 no 1147 0.350031200628297 368 2196908 SGTC_1548 st061468 90.8 µM 0.385016044517668 0.348134176281627 no 1148 0.350112764176683 390 390799 SGTC_2811 7967822 32.47 µM 0.384636822300251 0.348279389068528 no 1149 0.350253254431926 359 2232244 SGTC_865 0488-0499 301 µM 0.383417114856447 0.348746593443624 no 1150 0.350705257680294 370 9634651 SGTC_2999 9069765 71.4286 µM 0.382851741825825 0.348963235346611 no 1151 0.350914847253451 385 2097066 SGTC_1644 st010134 20.9 µM 0.379925254493006 0.35008540422683 no 1152 0.352000450054684 407 3818134 SGTC_1525 8-methoxypsoralen 92.5 µM 0.379359923960711 0.350302332950056 no 1153 0.352210303158566 429 4114 Related to psoralen; DNA damaging agent. SGTC_1556 plumbagin 1.48 µM 0.378962072309568 0.350455025937103 no 1154 0.352358014375379 387 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3254 9136651 49.47 µM 0.378261247697246 0.350724056833011 no 1155 0.352618265157836 404 16454030 SGTC_2812 7970281 58.44 µM 0.376737645648955 0.351309191758757 no 1156 0.353184291742638 389 2233435 SGTC_2516 gossypol 71.55 µM 0.376656706502042 0.351340286077697 no 1157 0.35321437018411 388 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_274 sirtinol 40.1 µM 0.37525338389751 0.351879557273185 no 1158 0.353736015711592 344 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2185 6113692 200 µM 0.373733149527751 0.352464091915837 no 1159 0.354301429919098 386 874150 SGTC_2248 tofa 1.1 µM 0.372535819510601 0.352924714359917 no 1160 0.354746973966884 394 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3287 9117173 37.0625 µM 0.372361156997224 0.352991926465883 no 1161 0.354811985074682 371 2789709 SGTC_2130 NSC 7 2.4545 µM 0.371203687488014 0.353437449630313 no 1162 0.355242913399963 369 21448 SGTC_2808 7946468 45.46 µM 0.371179220870943 0.35344686927937 no 1163 0.355252024373214 401 2970879 SGTC_2325 6158266 200 µM 0.371100951688025 0.353477003522391 no 1164 0.355281171109193 362 3623240 SGTC_1971 st069429 63.5 µM 0.370678923804201 0.353639503356692 no 1165 0.355438345062478 381 1246522 YGL099W LSG1 SGTC_2749 bexarotene 57.39 µM 0.369872642964802 0.353950032109951 no 1166 0.355738692966656 365 82146 An retinoic acid receptor inhibitor. SGTC_1113 artemisinin 1.17947 µM 0.368639127649422 0.354425292755358 no 1167 0.356198363412069 396 2240 An anti-malaria and mitochondrial poison. SGTC_667 1498-1044 59 µM 0.368011422020604 0.354667228325277 no 1168 0.356432358707747 409 6739982 SGTC_3040 9091894 49.47 µM 0.36745333361469 0.354882380687823 no 1169 0.356640447586076 374 25236966 SGTC_1278 0874-0585 172 µM 0.365465884833304 0.355648950773695 no 1170 0.357381834082954 374 766306 SGTC_3039 9090270 49.47 µM 0.364359431142744 0.35607596949277 no 1171 0.357794812818986 383 17173750 SGTC_829 1635-0120 117 µM 0.364301779197147 0.35609822432552 no 1172 0.357816335709984 379 285054 SGTC_1494 4358-1428 177 µM 0.364203308793662 0.356136237053458 no 1173 0.357853098181877 394 1564571 SGTC_2513 baicalein 25.65 µM 0.362907093866037 0.356636750673989 no 1174 0.358337143684612 386 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2096 5468907 200 µM 0.362762515715357 0.356692592646236 no 1175 0.358391147630439 390 759785 SGTC_137 0438-0332 85.389 µM 0.362464627362731 0.356807658947783 no 1176 0.358502426114318 403 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2541 muurolladie-3-one 83.07 µM 0.361910510716031 0.357021734040166 no 1177 0.358709452604359 418 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1112 tnp00069 1.16933 µM 0.361505973113185 0.357178049832819 no 1178 0.358860620291 394 145826 SGTC_874 0599-0792 117 µM 0.360938179806865 0.357397489057198 no 1179 0.359072830686899 412 765305 SGTC_1151 3909-8316 15.3 µM 0.360871501044759 0.357423261980991 no 1180 0.35909775445294 396 800431 SGTC_328 k915-0120 63.5 µM 0.360579945294543 0.357535962834039 no 1181 0.359206741733185 371 6624543 SGTC_102 gallobenzophenone 83.616 µM 0.360377420584905 0.357614256058541 no 1182 0.359282454812735 405 70837 SGTC_621 3584-0052 32.1 µM 0.357850485094802 0.358591636879552 no 1183 0.36022760363436 413 2273927 SGTC_1022 4477-0945 21.3 µM 0.356801046445535 0.358997816820119 no 1184 0.360620376406128 380 4648966 SGTC_2103 5378138 10 µM 0.356470090541167 0.359125944731466 no 1185 0.360744273600679 395 244142 SGTC_625 k213-0058 121 µM 0.354283484023952 0.359972876051086 no 1186 0.361563221975768 388 3655420 SGTC_1667 st014849 34.6 µM 0.350959350279496 0.361261718842324 no 1187 0.362809422378003 381 5348460 SGTC_1546 5-methoxyflavanone 78.7 µM 0.350943487924224 0.361267872831168 no 1188 0.362815372589274 383 147795 SGTC_1181 1222-0449 220 µM 0.349204618001782 0.361942705397138 no 1189 0.363467849756822 391 658318 SGTC_1115 galangin 695.678 nM 0.348147392656424 0.362353210735619 no 1190 0.363864746877019 427 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1143 3454-2408 5.08 µM 0.347895656722794 0.362450979520111 no 1191 0.36395927360491 392 X1143 SGTC_1059 3448-6867 171 µM 0.347771484460396 0.362499208641898 no 1192 0.364005903281925 389 3934407 SGTC_1927 st060202 13.8 µM 0.34702492824042 0.362789220749861 no 1193 0.364286295559785 388 688887 SGTC_205 1486-1330 71.903 µM 0.345328788352703 0.363448406708706 no 1194 0.364923603171917 397 4118834 SGTC_1807 st050092 58.9 µM 0.345173072720574 0.363508944165892 no 1195 0.364982130502595 403 5008496 SGTC_1884 5633444 25 µM 0.34500730304914 0.363573394070633 no 1196 0.365044440204985 378 5724239 SGTC_1986 st071812 45 µM 0.34468250620333 0.363699683644669 no 1197 0.36516653556219 402 11838594 SGTC_578 3460-0051 92 µM 0.34459861662365 0.363732304531435 no 1198 0.365198072967602 435 2876744 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.344305618843377 0.363846245946726 no 1199 0.365308229553978 383 803109 SGTC_2338 7999974 200 µM 0.343393385927062 0.36420107350928 no 1200 0.365651267319353 412 315925 SGTC_1339 1486-1321 22.7 µM 0.343184335425742 0.364282403449855 no 1201 0.365729894205206 400 3469382 SGTC_1992 st073643 23.3 µM 0.341897099007907 0.364783330202896 no 1202 0.366214166442312 376 3161292 SGTC_961 1252-1571 372 µM 0.341683850021996 0.364866338149529 no 1203 0.366294413615141 416 6813498 SGTC_1868 st057644 42.7 µM 0.341471506822173 0.364948999809714 no 1204 0.36637432574408 371 688665 SGTC_3183 9108214 49.47 µM 0.341323527718472 0.365006609314281 no 1205 0.366430018852147 399 4974831 SGTC_1748 st037455 53.6035 µM 0.341266275254596 0.365028898995661 no 1206 0.366451567025299 410 580690 SGTC_1854 st056233 32.9 µM 0.340629237138727 0.365276943122143 no 1207 0.366691358156062 406 5393174 SGTC_2848 9016370 25.97 µM 0.340214822184097 0.365438334529426 no 1208 0.366847378383054 396 7894410 SGTC_1863 st057641 20.1 µM 0.339481865599459 0.36572383838261 no 1209 0.367123377997565 413 3921635 SGTC_2143 5623677 140.463 µM 0.336500621841215 0.366885868217981 no 1210 0.368246691363427 390 5375313 SGTC_142 0335-0849 62.6745 µM 0.336474181376265 0.366896179665197 no 1211 0.368256659016735 370 3889043 YPR107C YTH1 SGTC_2236 dapsone 200 µM 0.336471622913672 0.366897177438375 no 1212 0.368257623522942 385 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_71 0417-1750 47.813 µM 0.336291188605091 0.366967547165573 no 1213 0.368325646939747 362 6811472 SGTC_382 3229-0966 23.2 µM 0.336007501199565 0.36707819483733 no 1214 0.368432604938242 410 5722370 SGTC_3160 9100216 49.47 µM 0.335923487625341 0.367110965088995 no 1215 0.368464282336679 409 17191039 SGTC_1366 1683-0113 21.9 µM 0.335559057567252 0.367253125522604 no 1216 0.368601701385698 376 708623 SGTC_113 0099-0221 2.5 µM 0.33528608634503 0.367359620723274 no 1217 0.368704644205824 431 89219 SGTC_1216 1165-0504 9.65 µM 0.334487006674759 0.367671427043942 no 1218 0.369006047012094 417 6304004 SGTC_584 0986-0246 15.4 µM 0.334459308216229 0.367682236736398 no 1219 0.369016495968241 425 53315 YDR232W HEM1 SGTC_54 0159-0055 9 µM 0.334184440676286 0.36778951313581 no 1220 0.369120192141739 410 3319099 SGTC_839 0122-0028 230 µM 0.333324382392293 0.368125246707159 no 1221 0.369444718121824 401 759448 SGTC_2915 7971052 15.16 µM 0.332140446810104 0.368587574235649 no 1222 0.369891604954593 410 5741558 SGTC_2691 st077356 60.2 µM 0.33209811184297 0.368604109592476 no 1223 0.36990758791611 408 2839272 SGTC_515 4092-1064 102 µM 0.331903714136191 0.368680041331289 no 1224 0.369980982875334 428 717353 SGTC_586 0957-0265 8.15 µM 0.331137172204983 0.368979502531619 no 1225 0.370270437325357 436 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_392 N-ethylmaleimide 8.33 µM 0.330670261923266 0.369161947093135 no 1226 0.370446783673189 373 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2179 6298986 200 µM 0.330454278128352 0.369246352443249 no 1227 0.370528367344805 409 738374 SGTC_3255 9139072 49.47 µM 0.327688947723016 0.370327585014704 no 1228 0.371573430420269 382 17646060 SGTC_688 0527-0193 473 µM 0.327180600258913 0.370526458557913 no 1229 0.371765646449122 399 4007154 SGTC_3352 9151559 45.5865 µM 0.325941155698069 0.371011493763569 no 1230 0.372234438381743 378 17159339 SGTC_662 k832-1615 104 µM 0.325494050435455 0.371186511032863 no 1231 0.37240359238039 433 5878478 SGTC_3142 9086498 49.47 µM 0.325319348782046 0.37125490442131 no 1232 0.372469694207426 423 25236367 SGTC_2471 5466956 24.79 µM 0.325268204229731 0.371274927607093 no 1233 0.372489046471689 402 724419 SGTC_2553 4-methylesculetin 85.09 µM 0.324458101340085 0.371592130803626 no 1234 0.372795619095289 386 5319502 SGTC_1223 0764-0573 147 µM 0.323661082743012 0.37190429584013 no 1235 0.3730973187935 392 1609797 SGTC_3219 9131112 49.47 µM 0.323514706400731 0.371961635628341 no 1236 0.373152735876037 381 17612988 YMR079W SEC14 SGTC_464 bw-b 70c 158 µM 0.322994819899859 0.372165312945777 no 1237 0.373349582556893 426 5353454 SGTC_2165 5727197 32.143 µM 0.322796805872243 0.372242898837802 no 1238 0.373424566086716 419 1361712 SGTC_1689 st020265 53.493 µM 0.322669192684727 0.37229290300838 no 1239 0.373472892916466 417 5758320 YPR016C TIF6 SGTC_530 4358-1714 28 µM 0.317780669421432 0.3742100442055 no 1240 0.375325657395422 425 1564641 SGTC_1167 k781-0610 148 µM 0.317312591233746 0.374393775444077 no 1241 0.375503212121448 391 4525169 SGTC_163 TUB2.036 7.546 µM 0.316380973821833 0.374759541130382 no 1242 0.375856678270245 405 15992207 YJR013W GPI14 SGTC_2926 9010726 65.15 µM 0.316187969604706 0.374835331317966 no 1243 0.37592991928471 393 2994293 SGTC_1755 st041960 45.185 µM 0.314495937882462 0.375499976325758 no 1244 0.376572200587352 424 2257073 SGTC_82 0054-0107 293.755 µM 0.313729626324363 0.375801112025434 no 1245 0.376863198718698 388 3104697 SGTC_2433 5607874 27.82 µM 0.313499087212425 0.375891721266124 no 1246 0.376950757032381 410 2252428 SGTC_1824 st053723 68.6 µM 0.310967711405824 0.376887081974689 no 1247 0.377912584040256 405 675225 SGTC_1014 4130-3005 69.3 µM 0.310437194442997 0.377095790223832 no 1248 0.378114256598181 402 743608 SGTC_2479 5617353 43.85 µM 0.310386557619417 0.377115712903084 no 1249 0.378133507593238 429 2731746 SGTC_2925 9010536 32.5 µM 0.310075141625441 0.377238244385454 no 1250 0.378251907684436 375 2994177 SGTC_459 nigericin 15.3 µM 0.309773786811838 0.377356828907959 no 1251 0.378366493409099 413 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_222 nsc-310342 10.666 µM 0.308538138077213 0.377843183252923 no 1252 0.378836442375668 435 432556 SGTC_617 3770-0098 35 µM 0.307572561574636 0.378223371379465 no 1253 0.379203800694493 403 5962639 SGTC_2004 4023728 41.89 µM 0.306869714824096 0.378500185932419 no 1254 0.379471270827765 446 360084 YDR527W RBA50 SGTC_373 0844-0104 25.9 µM 0.306851692622847 0.378507284754913 no 1255 0.379478129981841 412 5375804 SGTC_3095 9117207 49.47 µM 0.306389648537848 0.378689294770783 no 1256 0.37965399445324 420 17015229 SGTC_323 4013-0906 34.3 µM 0.305790189663883 0.378925475799137 no 1257 0.379882199215382 416 2910086 SGTC_1058 3448-5425 97.3 µM 0.305225354598939 0.379148056754436 no 1258 0.380097261508889 433 7279705 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.305088448475682 0.379202012514524 no 1259 0.380149394426128 414 23665772 A membrane-active detergent. SGTC_2428 5615643 7.78 µM 0.305035064065483 0.379223052360495 no 1260 0.380169723435288 440 2253075 SGTC_2843 9000894 45.46 µM 0.30431021859938 0.37950876359701 no 1261 0.380445780394858 371 2242070 SGTC_707 0865-0008 204 µM 0.303664188500972 0.379763463769909 no 1262 0.380691871899218 427 723043 SGTC_33 0986-0033 35.816 µM 0.302235787767898 0.380326802025887 no 1263 0.381236162213715 398 2848082 SGTC_3008 9078912 71.4286 µM 0.30067004916163 0.380944595828225 no 1264 0.381833054926958 431 16648731 SGTC_823 0417-1665 178 µM 0.299782045075638 0.381295110818513 no 1265 0.382171705880557 431 3429856 SGTC_3262 9137218 49.47 µM 0.299337580425749 0.381470587507825 no 1266 0.382341241651501 396 17650664 SGTC_1031 k035-0009 16 µM 0.298686428733015 0.381727709182288 no 1267 0.382589656466824 427 5180959 SGTC_147 4466-0538 29.23 µM 0.298258484675462 0.381896720805265 no 1268 0.382752943735888 379 6742687 YHR072W ERG7 SGTC_2727 riluzole 51.77 µM 0.297739574950959 0.38210168847785 no 1269 0.382950968020454 422 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1937 st074714 47.2 µM 0.297503862742755 0.382194804960758 no 1270 0.383040929693541 410 17250970 SGTC_541 4513-1321 94 µM 0.295903880681441 0.382827046689507 no 1271 0.383651743680361 395 747515 SGTC_253 dyclonine 31.25 µM 0.293268795316058 0.383868995323968 no 1272 0.384658351642753 395 3180 An oral anasthetic. SGTC_1291 0993-0025 5.79 µM 0.293244415344814 0.383878639430298 no 1273 0.384667668484408 422 4353356 SGTC_547 1120-0019 610 nM 0.288773822549591 0.385648303958552 no 1274 0.386377232826107 408 3676939 SGTC_611 3453-1652 23.7 µM 0.287349737898073 0.386212523831922 no 1275 0.386922271160862 420 1560575 SGTC_2605 digitonin 300 nM 0.287162054234802 0.386286901752861 no 1276 0.386994119780022 409 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_938 3126-1755 342 µM 0.286700020191553 0.386470020900517 no 1277 0.38717101106304 443 1777771 SGTC_1975 st070967 30.8 µM 0.286181986444181 0.386675364623297 no 1278 0.387369369884829 458 261391 SGTC_1287 0971-0001 34.6 µM 0.284706783386768 0.38726029495954 no 1279 0.387934396626496 396 4665869 SGTC_959 1222-0044 107 µM 0.284383084476892 0.387388678585979 no 1280 0.388058410364062 426 6083612 SGTC_2995 9067767 71.4286 µM 0.284080432417409 0.387508725871701 no 1281 0.388174371076074 405 11673567 SGTC_2616 abietic acid 100 µM 0.283442252996222 0.387761895709569 no 1282 0.388418921291923 438 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1909 st060837 51.5 µM 0.283366106191374 0.387792106820566 no 1283 0.38844810368708 423 678937 SGTC_2490 carminic acid 95.39 µM 0.283050958900392 0.387917148175652 no 1284 0.388568886988962 419 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3349 9149703 23.001 µM 0.282993251974848 0.387940045878581 no 1285 0.388591004903742 405 4910494 SGTC_1954 st077032 68.9 µM 0.28246839198525 0.388148324516314 no 1286 0.388792189854485 440 698907 SGTC_2584 androsterone 48.74 µM 0.282217092637272 0.388248058287673 no 1287 0.388888526386409 405 2754130 A steroid. SGTC_417 st075190 100 µM 0.28213779168075 0.388279532177404 no 1288 0.388918928119087 450 222757 SGTC_664 1222-0054 14.9 µM 0.281756319962421 0.388430945378047 no 1289 0.389065183035965 407 6813991 SGTC_288 1315-0019 35.1 µM 0.280980267890713 0.388739027151356 no 1290 0.38936276717519 423 6811474 SGTC_2197 6588183 93.1375 µM 0.280314719366185 0.389003296327186 no 1291 0.389618029436284 403 884136 SGTC_3260 9137109 49.47 µM 0.278565668699248 0.389698035965048 no 1292 0.390289081269667 430 17478346 SGTC_2124 5246320 200 µM 0.277811058883036 0.389997883205084 no 1293 0.390578700736498 429 579342 SGTC_2835 9006588 71.43 µM 0.277104043859328 0.390278877871864 no 1294 0.390850108408915 363 2345538 SGTC_1687 st020778 55.3625 µM 0.275970180307579 0.390729638024004 no 1295 0.391285484912603 437 4259299 SGTC_1465 k213-0056 144 µM 0.27561284037311 0.390871726679958 no 1296 0.391422723168488 408 24048857 YMR208W ERG12 SGTC_1845 st056753 3.01 µM 0.275578693520999 0.390885305215396 no 1297 0.391435838152009 394 5375839 SGTC_489 paxilline 115 µM 0.274470154251957 0.391326189316872 no 1298 0.391861668343984 420 105008 A toxic potassium channel blocker. SGTC_1897 st060201 15 µM 0.273870679838803 0.391564668264837 no 1299 0.392092002253682 414 611878 SGTC_366 0181-0206 4.31 µM 0.273355528774425 0.391769634821807 no 1300 0.392289967121102 412 274874 SGTC_1341 1486-1360 280 µM 0.272857581375431 0.391967785000626 no 1301 0.392481347375372 448 3976547 SGTC_936 3005-4620 401 µM 0.272401173166981 0.392149429940649 no 1302 0.39265678536993 457 777207 SGTC_117 lucigenin 22.078 µM 0.27239345106794 0.392152503444874 no 1303 0.392659753842525 429 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1766 st045414 44.774 µM 0.271461502691881 0.392523481383831 no 1304 0.393018052393307 419 253960 SGTC_554 4483-2211 187 µM 0.270129678048747 0.39305380635241 no 1305 0.393530245372013 410 747107 SGTC_3207 9114163 49.47 µM 0.269798711373206 0.39318562623166 no 1306 0.393657557124379 447 849233 SGTC_1762 st045503 25.4615 µM 0.268653906241543 0.393641682129097 no 1307 0.394098012758973 424 4645554 SGTC_680 0417-1641 114 µM 0.26680895702431 0.394376961216528 no 1308 0.394808128737657 416 2835990 SGTC_684 1140-0066 328 µM 0.266760993422051 0.394396081481975 no 1309 0.394826594471542 408 6813534 SGTC_1567 st069303 68.4 µM 0.266688747274191 0.394424882249546 no 1310 0.394854409303362 443 5581319 SGTC_62 0180-0423 3.232 µM 0.266341978731983 0.394563128795333 no 1311 0.394987922960709 440 30102 YGL099W LSG1 SGTC_340 k038-0059 454 µM 0.264749998451543 0.395197975273495 no 1312 0.395601029065691 424 23733424 SGTC_724 3910-0327 137 µM 0.264201405136466 0.395416806692845 no 1313 0.395812364191973 451 2885483 SGTC_788 1182-0090 188 µM 0.263599249869249 0.395657041701736 no 1314 0.396044368303203 386 5715185 SGTC_3257 9139206 32.98 µM 0.263326233297703 0.395765977073827 no 1315 0.396149570864905 436 4910041 SGTC_1878 temozolomide 1 mM 0.263308893361758 0.395772896095141 no 1316 0.39615625278693 441 5394 DNA alkylating agent. SGTC_2931 9014674 55.67 µM 0.263122985902005 0.395847079382667 no 1317 0.39622789390413 410 2996810 SGTC_2828 7998861 71.43 µM 0.262568341954989 0.396068423256249 no 1318 0.396441651769524 445 2988188 SGTC_3353 9151644 39.2805 µM 0.261100352505673 0.39665442095146 no 1319 0.397007559923269 462 4909158 SGTC_1275 0867-0008 21.1 µM 0.25981229134309 0.397168786547418 no 1320 0.397504284671686 434 3422836 SGTC_2100 5377183 190 µM 0.259811945916434 0.397168924511788 no 1321 0.397504417903508 427 2844202 SGTC_1588 farnesol 29.9 µM 0.259512336297416 0.397288594273231 no 1322 0.397619982494945 421 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_158 k038-0087 26.446 µM 0.25745555305528 0.398110372960432 no 1323 0.398413561290146 418 X158 SGTC_624 k048-0052 28 µM 0.254393728472627 0.399334548103899 no 1324 0.39959569779422 416 6835531 SGTC_1524 corynanthine 62.1 µM 0.254079218550374 0.39946035139572 no 1325 0.399717178930728 434 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_361 000s-0510 1.45 µM 0.253889575150942 0.399536213393564 no 1326 0.399790434398617 402 660 SGTC_2796 7949634 45.45 µM 0.253630818040705 0.399639728684098 no 1327 0.399890392805558 418 2971588 SGTC_2387 9077560 195.08 µM 0.252947154916525 0.399913260743436 no 1328 0.400154524832721 410 5303272 SGTC_483 fpl-64176 144 µM 0.251400339753389 0.400532319056966 no 1329 0.400752302527283 448 3423 SGTC_970 1315-0089 19.5 µM 0.250453052674986 0.400911560866311 no 1330 0.401118503218824 417 6811083 YLR033W RSC58 SGTC_3193 9111931 49.47 µM 0.250300821837915 0.400972514467168 no 1331 0.401177360479043 426 17087244 SGTC_675 1309-0189 238 µM 0.24937265084211 0.401344208518811 no 1332 0.401536269242091 391 4246530 SGTC_2228 7354201 200 µM 0.248596713225849 0.401655007947837 no 1333 0.401836375583394 446 753451 SGTC_3071 9117417 49.47 µM 0.24806697660772 0.401867228072878 no 1334 0.402041292997372 447 45595590 YGL055W OLE1 SGTC_1005 4092-0690 4.4 µM 0.247823615648466 0.401964731685854 no 1335 0.40213544107152 426 1529343 SGTC_1169 aniline yellow 25.8 µM 0.244752301743987 0.40319578928343 no 1336 0.403324114203933 456 6051 A DNA damaging agent. SGTC_1158 4092-0494 91.8 µM 0.244162209904515 0.403432422820212 no 1337 0.403552596782104 440 1148199 SGTC_269 exalamide 29 µM 0.242349873012004 0.40415941123403 no 1338 0.404254536114725 419 3316 A derivative of salicylamide. SGTC_2264 7948757 110.76 µM 0.241776744581256 0.404389381079863 no 1339 0.404476579759406 435 2971411 SGTC_598 3937-0236 20.2 µM 0.241497230933868 0.404501548927489 no 1340 0.404584881190282 434 1379313 SGTC_1513 0337-0559 19 µM 0.24063311777552 0.404848364115516 no 1341 0.404919739993112 417 775073 SGTC_2744 captopril 92.04 µM 0.240356864238678 0.404959255333399 no 1342 0.40502680772037 441 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2210 7115885 190.385 µM 0.240254613432197 0.405000301871082 no 1343 0.405066438921865 461 2927039 SGTC_1926 methyl fluorone black 53.6 µM 0.240193884684316 0.405024680704965 no 1344 0.405089977126109 425 72721 Reacts with homocysteine. SGTC_264 promethazine 12.5 mM 0.240178005036811 0.405031055461469 no 1345 0.405096132066536 458 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3327 9140648 26.9345 µM 0.240115227708622 0.405056257160617 no 1346 0.405120464745499 463 8029710 SGTC_1756 st041558 35.5 µM 0.239649103483599 0.405243393114601 no 1347 0.405301147346712 437 3955792 SGTC_1487 3970-0795 2.82 µM 0.238462993546398 0.405719680988903 no 1348 0.405761007204189 414 3765103 SGTC_183 3914-0051 30.55 µM 0.238255155357495 0.405803153759645 no 1349 0.405841600363988 449 1596232 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.23760936980722 0.406062543943127 no 1350 0.406092041286082 447 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1313 1220-0047 237 µM 0.237197046682328 0.406228181756711 no 1351 0.406251963677536 432 3528706 SGTC_2820 7989630 71.43 µM 0.235630053969003 0.406857824524084 no 1352 0.406859875157425 430 2984098 SGTC_1998 st075797 76.8 µM 0.234652673219814 0.407250673822692 no 1353 0.407239161707217 460 24208315 SGTC_3301 9125354 19.7965 µM 0.232418549309277 0.408149009437907 no 1354 0.408106471538531 410 41905162 SGTC_2445 5742597 35.57 µM 0.232192536702036 0.408239915520803 no 1355 0.408194237111304 420 1774255 SGTC_1390 3413-2614 145 µM 0.23199359026982 0.408319939218778 no 1356 0.408271496115937 464 3421432 SGTC_2196 6573537 42.6665 µM 0.231677712850067 0.408447004788126 no 1357 0.408394171511243 457 2903087 SGTC_1067 clotrimazole 1.36 µM 0.230864117900769 0.408774327638624 no 1358 0.408710183755161 425 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3226 9131256 49.47 µM 0.230648857554521 0.408860941130229 no 1359 0.408793803978349 423 17178073 SGTC_3283 9109332 35.8195 µM 0.230069197636176 0.409094198818456 no 1360 0.409018999812269 447 17027281 SGTC_1073 triclabendazole 3.09 µM 0.229932814149377 0.409149084812005 no 1361 0.409071988683158 415 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1527 coumarin 137 µM 0.228494764045193 0.409727920037251 no 1362 0.4096308130797 472 323 A hepatotoxic, DNA x-linker. SGTC_2393 9031399 185.94 µM 0.227001207813076 0.410329305594692 no 1363 0.410211401492615 430 1526623 YDL150W RPC53 SGTC_456 gingerol 170 µM 0.226559461770399 0.410507216641324 no 1364 0.410383158709827 444 442793 A herb. SGTC_1273 0849-0096 14.1 µM 0.226326497137809 0.410601049421365 no 1365 0.410473745636349 449 5286025 SGTC_166 k072-0058 166.424 µM 0.226145846521703 0.410673814845062 no 1366 0.410543993853613 475 5846229 SGTC_435 c-PAF 6.7 µM 0.225909123886812 0.410769170531586 no 1367 0.410636050710096 463 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1001 4048-4355 44.4 µM 0.22540827284657 0.410970938766727 no 1368 0.410830838218674 447 21824233 SGTC_949 1165-0505 146 µM 0.225034793862022 0.411121410404511 no 1369 0.410976103388319 419 6244267 SGTC_2730 imipramine 71.33 µM 0.224608457736578 0.41129319373687 no 1370 0.41114194233885 414 3696 A tricyclic antidepressant. SGTC_231 b-estradiol 524 µM 0.224385688763072 0.41138296065951 no 1371 0.411228602756706 435 450 A steroid. SGTC_3069 9117009 49.47 µM 0.222546760316525 0.412124151548958 no 1372 0.411944138154892 445 41904981 SGTC_3114 9122766 49.47 µM 0.221429840733196 0.412574485772951 no 1373 0.41237887974882 411 17176985 SGTC_2905 7799065 20.05 µM 0.220897738325432 0.41278906628836 no 1374 0.412586029239805 457 1296806 SGTC_3012 9080433 71.4286 µM 0.219967971895011 0.413164074981158 no 1375 0.412948049260194 465 17688859 SGTC_944 3370-0224 231 µM 0.21951211896757 0.413347966055457 no 1376 0.41312557024829 421 4580514 SGTC_1117 retinoic acid 1.10837 µM 0.218954184896418 0.413573062532664 no 1377 0.41334286846276 458 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2317 5986382 200 µM 0.216891269935603 0.414405584216896 no 1378 0.414146540628067 463 877883 SGTC_2521 angolensin 13.4 µM 0.216666076601426 0.414496487874375 no 1379 0.414234293471397 450 821428 A flavenoid. SGTC_2830 7992007 71.43 µM 0.216111845955607 0.414720233321365 no 1380 0.414450283078577 461 1952075 SGTC_1819 st053448 58.6 µM 0.214825191778363 0.41523976806085 no 1381 0.414951805606084 464 2857616 SGTC_2384 9036245 200 µM 0.214712763368529 0.415285172291281 no 1382 0.414995635463945 465 6462766 SGTC_1653 st012112 65 µM 0.213992890977391 0.415575919653769 no 1383 0.415276300478931 452 720429 SGTC_645 0845-0943 5.41 µM 0.213665706210386 0.415708080736114 no 1384 0.415403878106896 436 1885106 SGTC_1808 st050063 61.5 µM 0.212697556518181 0.416099205199343 no 1385 0.415781436387156 478 4011993 SGTC_1723 st034307 2.5525 µM 0.211144715835421 0.41672671338195 no 1386 0.416387174247009 439 867466 SGTC_854 0422-0053 192 µM 0.210654766367342 0.416924747746867 no 1387 0.416578336845378 447 3596728 SGTC_3289 9119912 71.43 µM 0.209945867817487 0.417211317201839 no 1388 0.416854961282159 443 17014829 SGTC_2166 5933061 31.504 µM 0.209646152663892 0.4173324891141 no 1389 0.416971927694064 443 2877375 SGTC_1785 bathophenanthroline 24 µM 0.209213963738952 0.41750723270059 no 1390 0.417140606070481 423 72812 An iron chelator. SGTC_2496 diffractaic acid 79.83 µM 0.205634113479872 0.418955268969197 no 1391 0.418538364123559 428 94870 An apoptosis inducer which activates caspases. SGTC_2081 5214970 32.255 µM 0.205545154651609 0.418991266558378 no 1392 0.418573111413324 439 2063512 SGTC_3153 9100258 49.47 µM 0.205341128572058 0.419073829188291 no 1393 0.418652806333705 471 25236848 SGTC_466 geldanamycin 89.2 µM 0.205205493106514 0.419128718363187 no 1394 0.41870578894583 453 5288382 HSP90 inhibitor. SGTC_3231 9132313 49.47 µM 0.204860861794586 0.419268191386319 no 1395 0.41884041720503 456 4905967 SGTC_1205 4161-2785 76 µM 0.203586870654588 0.419783866239546 no 1396 0.419338176984375 417 3498106 SGTC_1048 3161-0300 24.5 µM 0.203267297711844 0.419913241793889 no 1397 0.419463057290053 433 2165101 SGTC_2698 st077697 67.5 µM 0.201965509568179 0.42044034555508 no 1398 0.419971843947964 465 3154499 SGTC_2598 perillyl alcohol 100 µM 0.201212128854135 0.420745460295377 no 1399 0.420266353993933 442 10819 An apoptosis inducer. SGTC_2597 laccaic acid a 100 µM 0.201144732851342 0.420772757601597 no 1400 0.420292702479419 447 5491415 A textile dye. SGTC_651 3253-0966 34.4 µM 0.200142767225167 0.421178627161244 no 1401 0.42068446327778 433 781462 SGTC_885 0865-0106 16.8 µM 0.199582491541941 0.421405616449919 no 1402 0.420903561004935 443 2793380 SGTC_1555 citronellol 128 µM 0.198995330554713 0.421643526043443 no 1403 0.421133198614192 482 8842 A terpine precursor. SGTC_2026 5148700 152 µM 0.196557010998831 0.422631804835551 no 1404 0.422087107249086 435 79838 SGTC_1781 st038725 66.3 µM 0.196526188202446 0.422644300798567 no 1405 0.422099168546014 415 4270275 YIL048W NEO1 SGTC_368 fentichlor 4.58 µM 0.19629258977537 0.422739007172457 no 1406 0.422190580536619 457 7329 A pesticide. SGTC_343 4130-2827 29.8 µM 0.196079016207879 0.422825598898854 no 1407 0.42227416004559 423 1118244 SGTC_1200 1643-0193 18.4 µM 0.194016981654342 0.42366182582083 no 1408 0.423081292556898 470 5403974 SGTC_2544 sphondin 68.51 µM 0.194011337025907 0.423664115388217 no 1409 0.423083502452098 477 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2175 5807670 165.306 µM 0.193768387193381 0.423762662848231 no 1410 0.423178620601484 449 241186 SGTC_2271 7849410 118.62 µM 0.193580147528486 0.423839021564922 no 1411 0.423252322058509 465 972430 SGTC_3348 9149464 3.537 µM 0.191083992258596 0.42485184693035 no 1412 0.424229894442534 437 1951442 SGTC_2234 tolnaftate 200 µM 0.188047352668898 0.42608464458562 no 1413 0.425419765599955 473 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1434 4073-0095 163 µM 0.1879478231175 0.42612506332371 no 1414 0.425458776633554 468 24133745 SGTC_15 0266-0086 27.098 µM 0.187483410473596 0.426313670557783 no 1415 0.425640814797573 474 1712902 YIL048W NEO1 SGTC_3037 9091026 49.47 µM 0.187196511363311 0.426430194431382 no 1416 0.425753280010439 459 25236398 YIL048W NEO1 SGTC_1988 st071872 53.4 µM 0.186472284142441 0.426724367357645 no 1417 0.426037205852267 471 16414116 SGTC_1760 st045453 10.4495 µM 0.185921171239332 0.426948250522432 no 1418 0.426253289704658 491 3323419 YIL048W NEO1 SGTC_3269 9137823 49.47 µM 0.184760522801528 0.42741982725118 no 1419 0.426708436468044 492 17682936 SGTC_1188 1403-0014 4.57 µM 0.184071069657308 0.427700004343475 no 1420 0.426978850867037 464 9614867 SGTC_1763 st044482 94.5 µM 0.18390329639057 0.427768188864971 no 1421 0.427044659385444 485 88505 SGTC_2062 5245942 200 µM 0.181909526275797 0.428578639045417 no 1422 0.427826864174188 455 1376160 SGTC_697 0508-1955 564 µM 0.17964360833579 0.429500080556974 no 1423 0.428716183531923 469 6243113 SGTC_2012 4023501 200 µM 0.177795372386397 0.430251955344245 no 1424 0.429441840874283 469 3477460 SGTC_3168 9103419 49.47 µM 0.177054776911725 0.430553305697719 no 1425 0.429732681713773 484 16649256 SGTC_2781 5567276 71.43 µM 0.176773914953574 0.430667599795296 no 1426 0.429842989599507 443 2853274 SGTC_3077 9117319 49.47 µM 0.176645959403901 0.430719672013227 no 1427 0.42989324566272 477 17154678 SGTC_1118 chelidonine 707.474 nM 0.176640658243279 0.430721829375824 no 1428 0.429895327781083 476 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_397 arbidol 50 µM 0.175114104091618 0.431343162275753 no 1429 0.430494988023407 449 131410 A RNA synthesis inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.174294552353605 0.431676803650443 no 1430 0.430816990155954 491 688669 SGTC_462 ag-879 158 µM 0.173361229767984 0.432056820749258 no 1431 0.431183748898917 482 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_942 3253-1115 227 µM 0.172855599364399 0.432262722470659 no 1432 0.431382466389261 470 46497897 SGTC_909 3448-9333 149 µM 0.171546647433794 0.432795836381405 no 1433 0.431896977333723 455 3344074 SGTC_3123 9126162 49.47 µM 0.171397636151122 0.432856533923229 no 1434 0.431955556677777 471 25239884 SGTC_2374 9071832 200 µM 0.169469621707454 0.433642024438972 no 1435 0.432713632547143 484 17381698 SGTC_1613 st002381 52.1 µM 0.168310439052888 0.434114412324076 no 1436 0.433169530920321 441 551167 SGTC_1315 1237-0019 3.69 µM 0.166449027378525 0.434873167837293 no 1437 0.433901796881179 481 825140 SGTC_2971 9092186 9.93 µM 0.166166430162474 0.434988382204813 no 1438 0.434012988493726 407 25236400 SGTC_1751 st044839 27.194 µM 0.166122334312718 0.435006360500146 no 1439 0.434030339060224 473 5291326 SGTC_2936 9038235 15.59 µM 0.164212936509963 0.435784968443391 no 1440 0.434781758744764 473 4749415 SGTC_2249 haloperidol 116.36 µM 0.16153869044348 0.436875881573913 no 1441 0.435834570458427 488 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2664 lyso-paf C-16 73.48 µM 0.161028871738122 0.437083908183323 no 1442 0.436035330507667 462 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1403 3909-7815 62.9 µM 0.160670124692269 0.437230301889415 no 1443 0.43617661036309 483 6615483 SGTC_1391 3442-0225 151 µM 0.160124099992181 0.437453134372051 no 1444 0.43639165853337 459 5227075 SGTC_1558 st069300 45.6 µM 0.158912480025987 0.437947666800477 no 1445 0.436868914002862 478 24208000 SGTC_2606 farnesol 9.78 µM 0.158101114195951 0.438278886522596 no 1446 0.437188561326766 489 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1220 1838-0075 193 µM 0.157670973264698 0.438454498307098 no 1447 0.437358037163407 472 5529645 SGTC_259 usnic acid 108.925 µM 0.157347882005379 0.438586413355195 no 1448 0.437485342913296 486 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.156898562838287 0.438769877380715 no 1449 0.437662396259853 490 5357218 A potent inhibitor of glutathione S-transferases. SGTC_596 1155-0152 116 µM 0.156651875967895 0.438870609075407 no 1450 0.437759608052806 494 280313 SGTC_1518 st038567 90.8 µM 0.156577838645586 0.438900842121731 no 1451 0.437788784642981 493 77966 SGTC_3294 9122953 26.2835 µM 0.156552862080836 0.438911041350575 no 1452 0.437798627471171 490 16459826 SGTC_167 3672-0051 66.205 µM 0.156465655705962 0.438946652561552 no 1453 0.437832994283026 480 3237971 SGTC_299 1273-0059 1.44 µM 0.156426862851112 0.438962493999655 no 1454 0.437848282154915 479 2848077 SGTC_1905 st060207 84.5 µM 0.155253324473892 0.439441765864981 no 1455 0.438310805513802 473 1948547 SGTC_2363 9053361 176 µM 0.154447060439949 0.439771094759226 no 1456 0.438628624954096 486 6469797 YMR079W SEC14 SGTC_1887 st057648 70.8 µM 0.153710403438905 0.440072028212413 no 1457 0.438919040757791 486 688672 SGTC_1332 1480-0653 17.5 µM 0.153047473992722 0.440342872656428 no 1458 0.439180418714025 491 5749438 SGTC_2929 9013348 24.6 µM 0.150847030451175 0.441242078615412 no 1459 0.440048192889924 468 2995952 SGTC_3067 9117431 49.47 µM 0.150702702605754 0.441301068480456 no 1460 0.440105120607585 478 17150885 SGTC_2747 doxorubicin 7.63 µM 0.150670476968056 0.441314239962974 no 1461 0.440117831643428 502 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_933 2914-0560 114 µM 0.150583806038367 0.441349665018714 no 1462 0.440152018310914 448 463887 SGTC_2638 epoxomicin 18 µM 0.150235547602716 0.441492013604383 no 1463 0.440289390611389 478 9915668 A protesome inhibitor. SGTC_594 1487-1584 10.8 µM 0.149133118239779 0.4419426748606 no 1464 0.440724296758002 471 5013332 SGTC_2009 4012297 12.05 µM 0.148162353406518 0.442339575324203 no 1465 0.441107320739622 453 45595307 SGTC_1430 4049-0248 69.1 µM 0.147885054982527 0.442452960362838 no 1466 0.441216741454763 481 22774488 SGTC_255 tunicamycin 200.472 nM 0.147188980416704 0.442737600260428 no 1467 0.441491429109349 480 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1166 k206-0078 225 µM 0.146063349269215 0.443197957591982 no 1468 0.441935689553483 447 5404595 SGTC_423 5-fluorouracil 457 µM 0.145038434658298 0.443617190885484 no 1469 0.442340263073209 465 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_887 0885-0007 9.62 µM 0.14472715471575 0.443744530024102 no 1470 0.442463149257356 488 5719458 SGTC_644 1498-1197 63.3 µM 0.144640625952619 0.443779928448476 no 1471 0.442497309812936 470 6741615 SGTC_401 neomycin 50 µM 0.143793416859988 0.444126540518955 no 1472 0.44283180071804 450 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1028 k015-0029 4.8 µM 0.143534167322214 0.444232613819717 no 1473 0.442934164492569 501 4588309 SGTC_2382 9035899 200 µM 0.143085553657475 0.444416175873612 no 1474 0.443111307026153 501 6462679 SGTC_2083 5306046 65.942 µM 0.142707017643583 0.444571073093761 no 1475 0.443260787085862 455 539837 SGTC_2862 9027634 71.43 µM 0.139937693602169 0.445704538579075 no 1476 0.44435460955236 483 5012562 SGTC_281 1672-3440 14.9 µM 0.139877032223591 0.44572937187065 no 1477 0.444378574246263 494 6833000 SGTC_2636 apigenin dimethyl ether 100 µM 0.139531189346099 0.445870955589396 no 1478 0.444515205730195 480 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2411 st077133 39.94 µM 0.139471191120146 0.445895518810655 no 1479 0.444538909786129 494 1403142 YNL221C POP1 SGTC_2740 felodipine 17.08 µM 0.138910127113852 0.446125227962279 no 1480 0.444760584139084 496 3333 L-type calcium channel blocker SGTC_1064 honokiol 6.76 µM 0.138114089537475 0.446451170302027 no 1481 0.445075125326787 488 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3167 9103034 49.47 µM 0.137931618236557 0.44652588937145 no 1482 0.445147230746925 451 5127859 SGTC_2622 2-methoxyxanthone 59.94 µM 0.137767152411563 0.446593237114316 no 1483 0.445212222672289 486 71034 A hepatoprotective. SGTC_2883 9059145 45.46 µM 0.137625519220276 0.446651236268824 no 1484 0.445268193010805 490 16476510 SGTC_75 0159-0059 199.013 µM 0.137081188225851 0.446874151815138 no 1485 0.445483310854946 500 5377270 SGTC_2568 diosmetin 100 µM 0.136124989321329 0.4472657769553 no 1486 0.445861236389626 498 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2104 5389443 200 µM 0.135959101543813 0.447333723947417 no 1487 0.445926806454738 471 2244536 SGTC_2849 9019321 12.99 µM 0.134026415336882 0.448125458138082 no 1488 0.446690843229766 494 16489627 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.13321964347414 0.448456017436376 no 1489 0.447009838033528 455 2724 A muscle relaxant with antifungal properties. SGTC_2105 5350118 200 µM 0.131958834438979 0.448972681344066 no 1490 0.447508426148433 472 2133313 SGTC_1874 staurosporine 7.6 µM 0.131935072744305 0.448982419425486 no 1491 0.447517823531789 502 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_727 3032-0951 202 µM 0.130456226313115 0.449588544479039 no 1492 0.4481027422255 487 3652836 SGTC_3187 9109394 49.47 µM 0.129977769049164 0.44978467186413 no 1493 0.448292007598188 482 17098090 SGTC_2442 5158906 48.48 µM 0.128871547219942 0.45023817700451 no 1494 0.44872964546333 505 1893835 SGTC_966 1300-0360 30.2 µM 0.128283559931669 0.4504792539324 no 1495 0.448962287439318 489 70588 SGTC_1393 3470-5649 58.2 µM 0.127652415815189 0.450738045647792 no 1496 0.449212024292882 499 4108395 SGTC_827 3253-0474 693 µM 0.127075440836041 0.450974644402509 no 1497 0.449440344616223 467 5402065 SGTC_2653 dihydrofissinolide 100 µM 0.126495230138538 0.451212587587308 no 1498 0.449669962258683 475 6857746 SGTC_859 0439-0102 54.6 µM 0.126282500480281 0.451299831968729 no 1499 0.449754153975543 475 610143 SGTC_2661 dactinomycin 12.96 µM 0.126216164420618 0.451327038099459 no 1500 0.449780408167117 494 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_607 4491-0986 66.8 µM 0.125813529596105 0.451492173936889 no 1501 0.449939765904856 490 698981 YDR232W HEM1 SGTC_1305 1181-0477 144 µM 0.125271811930853 0.451714366170841 no 1502 0.450154183593022 479 6252086 SGTC_2908 7930301 100 µM 0.12516954908556 0.451756312247365 no 1503 0.450194661963546 453 2223178 SGTC_2818 7996756 12.99 µM 0.125151644190203 0.451763656515716 no 1504 0.450201749253542 503 2241621 SGTC_764 1951-2361 146 µM 0.125092314165099 0.451787992750536 no 1505 0.450225233955184 478 5438930 SGTC_3088 9117578 49.47 µM 0.124634988288762 0.45197558664167 no 1506 0.450406263854392 497 678341 SGTC_766 1391-0721 126 µM 0.123972339614543 0.4522474224274 no 1507 0.450668587936755 492 1020919 YIL115C NUP159 SGTC_3247 9135149 49.47 µM 0.123595319781396 0.45240209580586 no 1508 0.450817849173363 499 8934436 YOR116C RPO31 SGTC_1771 st048882 4.1505 µM 0.123052811569746 0.452624673896724 no 1509 0.451032639056839 474 4580403 SGTC_2569 tetrandrine 100 µM 0.12282175457233 0.452719475558587 no 1510 0.45112412351475 446 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2798 7813637 45.45 µM 0.122474840690773 0.452861817845955 no 1511 0.451261485096049 504 956368 SGTC_79 0052-0007 94.094 µM 0.122016230844316 0.453049999415743 no 1512 0.451443081981157 499 2801472 SGTC_1242 0402-0103 60.1 µM 0.121780043086129 0.453146918553407 no 1513 0.451536609803843 480 432868 SGTC_1515 3460-0031 42.1 µM 0.121257009652628 0.453361554121393 no 1514 0.451743735009333 477 2876596 SGTC_50 0929-0078 56.389 µM 0.117886631198301 0.454744969687682 no 1515 0.453078743069187 498 1377751 SGTC_229 benomyl 22.8748 µM 0.117398538858529 0.454945359434033 no 1516 0.453272120944309 467 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2825 7998094 58.44 µM 0.116802269610053 0.455190177525907 no 1517 0.453508372588075 502 2987815 SGTC_3089 9117425 49.47 µM 0.116672915796328 0.455243290268796 no 1518 0.453559626862876 497 9401657 SGTC_3201 9113999 49.47 µM 0.116518237929613 0.455306802131158 no 1519 0.453620916383534 476 16649224 SGTC_1061 3448-9325 110 µM 0.116187028335904 0.455442803050389 no 1520 0.453752158506382 500 723482 SGTC_324 1315-0088 19.6 µM 0.113432905674598 0.456573898619641 no 1521 0.454843676551519 519 6787421 SGTC_2414 st077232 92.9 µM 0.112793194466611 0.456836673466379 no 1522 0.455097256970131 476 729801 SGTC_11 0438-0307 1.3 µM 0.111482515263681 0.457375121372945 no 1523 0.455616864982126 493 4011476 SGTC_38 0929-0051 58.268 µM 0.111410150198543 0.457404852383651 no 1524 0.455645555738154 498 1379719 SGTC_2055 5235184 200 µM 0.111134302967793 0.457518185731177 no 1525 0.455754923690856 502 2836034 SGTC_2277 7947813 106.88 µM 0.110606703403837 0.45773496252047 no 1526 0.455964115779749 503 1246798 SGTC_2534 helenine 20.12 µM 0.110588236106941 0.457742550475362 no 1527 0.455971438244596 493 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_22 0964-0034 14.468 µM 0.110548985111443 0.457758678213476 no 1528 0.455987001700017 500 138402 SGTC_2772 vinpocetine 57.06 µM 0.110176427473963 0.457911760898973 no 1529 0.456134728298073 507 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1396 3511-0007 98.6 µM 0.109895511733518 0.458027192365994 no 1530 0.45624612105141 504 X1396 SGTC_171 k064-0041 9.68 µM 0.108951153491482 0.458415265787841 no 1531 0.456620616737982 479 53325 SGTC_3087 9117406 49.47 µM 0.10806595454293 0.458779064362554 no 1532 0.456971687148022 476 42546093 SGTC_2751 anetholtrithion 17.25 µM 0.107562986110608 0.458985789453056 no 1533 0.45717117969671 492 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2493 resveratrol 26.09 µM 0.107521117284908 0.459002998462877 no 1534 0.457187786631284 501 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2717 st081029 62.2815 µM 0.106695361295457 0.459342418026349 no 1535 0.457515331375348 512 5292846 SGTC_3125 9127534 49.47 µM 0.106567876987509 0.459394821950342 no 1536 0.45756590193577 509 1639235 SGTC_41 0478-0632 82.643 µM 0.106117775757213 0.459579846990834 no 1537 0.457744453881927 511 3750424 SGTC_1173 0443-0020 122 µM 0.105965227196237 0.459642557769527 no 1538 0.457804970744342 492 5331295 SGTC_2086 5274770 176.623 µM 0.105298654067142 0.459916589287792 no 1539 0.458069415469201 499 689278 SGTC_1086 cerivastatin 2.18 µM 0.105134547623493 0.459984057186473 no 1540 0.458134523080738 493 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1228 0124-0032 52.5 µM 0.104247975593706 0.460348567029255 no 1541 0.458486281164879 488 X1228 SGTC_2719 novobiocin 32.65 µM 0.10390070786505 0.460491353592111 no 1542 0.458624072677173 475 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1959 st077091 55.8 µM 0.103529246551949 0.460644093504182 no 1543 0.458771469405641 509 821356 YKL052C ASK1 SGTC_3146 9095609 49.47 µM 0.101952626848656 0.461292442747302 no 1544 0.459397138682745 504 17173999 SGTC_722 3534-0461 190 µM 0.101323322132535 0.46155125892588 no 1545 0.459646901539892 482 658262 SGTC_2145 5634607 200 µM 0.101153873517578 0.461620951391059 no 1546 0.459714156216926 497 308662 SGTC_2354 9060492 162 µM 0.10070826151959 0.461804232622633 no 1547 0.459891026488011 484 6471895 SGTC_2524 avocatin b 10.57 µM 0.100678474779823 0.46181648426633 no 1548 0.459902849587596 515 6710748 SGTC_380 3970-0968 6 µM 0.0988548123685583 0.462566647086607 no 1549 0.460626773801499 507 2891601 SGTC_209 4077-0173 175.592 µM 0.0986342330449864 0.46265739138524 no 1550 0.46071434425031 499 15993494 SGTC_2319 6033012 152.6 µM 0.0957882228132759 0.463828386370641 no 1551 0.461844385590007 498 847246 SGTC_1351 1496-0003 46.5 µM 0.0946065368472248 0.464314685422528 no 1552 0.462313678737471 501 3891978 SGTC_195 4234-0266 16.654 µM 0.092494803908799 0.465183858865478 no 1553 0.463152459702666 518 2303354 SGTC_1381 2324-0066 62.1 µM 0.0918505248071738 0.465449072579092 no 1554 0.463408400349542 503 10885928 SGTC_3056 9094900 49.47 µM 0.0894488607353089 0.466437837804835 no 1555 0.46436259690613 485 25236784 SGTC_1281 0884-0031 11.8 µM 0.0891872060879016 0.466545573661847 no 1556 0.464466566459789 497 1548255 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0876189186309806 0.467191364464922 no 1557 0.465089782557918 519 140250 A respiratory chain inhibitor. SGTC_2146 5545642 200 µM 0.0869270419509625 0.46747629361688 no 1558 0.465364752253065 496 825326 SGTC_334 1502-1024 68.5 µM 0.0858848682165313 0.467905513764744 no 1559 0.465778970237396 509 3296216 SGTC_379 3970-0972 5.9 µM 0.0856928095989631 0.46798461735812 no 1560 0.465855309106105 503 2898042 YBL034C STU1 SGTC_732 3970-1727 52.7 µM 0.084614059573844 0.46842894783948 no 1561 0.466284110615859 518 1275699 SGTC_69 0096-0274 206.684 µM 0.084415523962727 0.468510727734819 no 1562 0.466363032501606 509 6741392 SGTC_2861 9024595 19.48 µM 0.0833531859138849 0.468948343735303 no 1563 0.466785355572579 516 16482810 SGTC_196 k015-0023 18.111 µM 0.0809226292897534 0.469949719409588 no 1564 0.467751741705539 508 5211998 SGTC_2762 leflunomide 42.06 µM 0.0796286827764338 0.470482896039299 no 1565 0.468266291044115 511 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_472 calcifediol 10 µM 0.0788179630622429 0.470816983863845 no 1566 0.468588708019144 505 5283731 A vitamin D metabolite. SGTC_2701 st077767 14.721 µM 0.0787031281387533 0.470864307618194 no 1567 0.468634378652888 482 5721188 SGTC_3065 9113888 49.47 µM 0.0783867211968006 0.470994701823645 no 1568 0.468760217989384 504 16648368 SGTC_3141 9094609 49.47 µM 0.0782061648890731 0.471069112130073 no 1569 0.468832029083786 510 25236309 YDL196W YDL196W SGTC_2195 6536160 144.242 µM 0.0773709901580083 0.471413314854661 no 1570 0.469164209043114 502 3834386 SGTC_2860 9025725 38.96 µM 0.0771588640690586 0.471500742339851 no 1571 0.46924858288198 517 40546248 SGTC_134 0269-0018 6.916 µM 0.0758580617241993 0.47203689617126 no 1572 0.469766011285912 507 4378915 SGTC_2480 5767542 37.17 µM 0.0757297935584743 0.472089767431737 no 1573 0.469817036108079 507 2867358 SGTC_2671 danthron 100 µM 0.0748789198716891 0.472440504153047 no 1574 0.470155524484113 506 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2280 7785178 200 µM 0.0740658531610648 0.47277567651751 no 1575 0.470478992917991 507 2954328 SGTC_3009 9080819 71.4286 µM 0.0739980333636091 0.472803634903275 no 1576 0.470505975060334 503 17027216 SGTC_3041 9091929 49.47 µM 0.072811493300024 0.473292801901741 no 1577 0.470978062452011 503 25236887 SGTC_1682 st012968 530 nM 0.0716694046147969 0.473763681276065 no 1578 0.471432502554176 488 24207270 SGTC_431 k089-0097 107 µM 0.0711714797723018 0.47396898555012 no 1579 0.471630639842082 511 5499420 SGTC_2353 9059630 146.67 µM 0.0710880359544947 0.474003391766699 no 1580 0.471663845002896 500 4779114 SGTC_2408 sulbentine 18.36 µM 0.0709499639405842 0.474060323140005 no 1581 0.471718789031527 469 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1700 st030840 7.9285 µM 0.0691496975423157 0.474802676865543 no 1582 0.472435231375464 494 5499307 SGTC_2591 skatole 100 µM 0.0688713540124167 0.474917461839539 no 1583 0.472546010273709 518 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3215 9129942 49.47 µM 0.0675741299280836 0.475452446195701 no 1584 0.473062324820418 523 17682944 SGTC_2373 9071805 200 µM 0.0667879318039209 0.475776701445663 no 1585 0.473375265491318 510 10149009 SGTC_444 curcumin 90.4 µM 0.0666308017670212 0.475841509228218 no 1586 0.473437811981242 502 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2572 astragaloside iv 100 µM 0.0652133192320144 0.476426174059816 no 1587 0.474002078244998 521 45006101 An anti-inflammatory agent. SGTC_1521 st012942 49.4 µM 0.0637978153790189 0.477010073399058 no 1588 0.474565608896074 515 24207259 SGTC_2585 alliin 100 µM 0.06337181782424 0.477185808314412 no 1589 0.474735214124541 530 87310 A garlic compound which reacts with lipids. SGTC_3042 9091578 49.47 µM 0.0629718917316146 0.477350792121412 no 1590 0.474894443516646 516 25236497 SGTC_3339 9145883 14.936 µM 0.0629560392562384 0.477357331914265 no 1591 0.474900755215672 524 2030670 SGTC_2662 daunorubicin 22.37 µM 0.0622737381244862 0.477638814724001 no 1592 0.475172420907956 516 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_588 3970-1144 52.9 µM 0.0617649652576723 0.477848715849409 no 1593 0.475375001934756 519 1888707 SGTC_2344 7990960 76.95 µM 0.0617149799394538 0.477869338300757 no 1594 0.475394905221503 508 140813 SGTC_1229 0139-0193 12.2 µM 0.0604478810388908 0.478392125153571 no 1595 0.475899462397661 498 3090752 SGTC_740 k014-0057 261 µM 0.0602975467626222 0.478454153407001 no 1596 0.475959327896309 528 4012779 SGTC_1170 0310-0127 64.8 µM 0.0601835726452622 0.47850117972669 no 1597 0.476004714563406 516 774975 SGTC_1747 st037496 66.6 µM 0.0596427154818888 0.478724344303342 no 1598 0.476220098434462 516 723305 SGTC_1500 4488-1866 171 µM 0.0593741535972166 0.478835158851392 no 1599 0.476327049586504 525 2900003 SGTC_2327 6189656 200 µM 0.0593440364116663 0.478847585967593 no 1600 0.476339043456349 521 5349088 SGTC_1497 4476-2978 41.3 µM 0.0590344764527602 0.478975319464016 no 1601 0.476462323874197 520 1528379 SGTC_2446 5162541 200 µM 0.0586333973069372 0.479140819664163 no 1602 0.476622054614262 518 1549321 SGTC_1195 1502-0147 41.1 µM 0.0586063206364584 0.479151992637217 no 1603 0.476632838099423 524 817940 SGTC_2897 9048598 12.99 µM 0.0582180440202162 0.479312213697093 no 1604 0.476787474024431 520 6467404 SGTC_2201 6605497 169.863 µM 0.0579488496016 0.479423297846259 no 1605 0.476894686056815 521 670741 SGTC_608 k048-0125 159 µM 0.0576252176657869 0.479556847968676 no 1606 0.477023581126658 520 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1916 st067606 49.2 µM 0.057124489099909 0.479763483395317 no 1607 0.477223014395644 512 19590279 SGTC_1715 st032160 10.2275 µM 0.0562859042986078 0.480109553951906 no 1608 0.477557023886596 525 5289825 SGTC_2972 9093619 59.92 µM 0.0553154039368352 0.480510082653219 no 1609 0.477943595194123 492 25236256 SGTC_149 3970-0822 46.1 µM 0.0551600223979012 0.480574210964922 no 1610 0.478005488962185 495 3114250 YBL034C STU1 SGTC_2099 5377090 177.372 µM 0.0550500866746281 0.480619583404788 no 1611 0.478049280431937 515 2243829 SGTC_2295 7971645 200 µM 0.0549960998122199 0.48064186484075 no 1612 0.478070785495555 520 2978226 YKL099C UTP11 SGTC_1246 0422-0085 105 µM 0.0541346446305203 0.480997412409352 no 1613 0.478413945140861 530 264295 SGTC_453 enantio-paf c16 10 µM 0.0540136177306222 0.481047364942913 no 1614 0.478462157350185 524 13871343 A lipid and platelet activating factor SGTC_455 paf C-16 10 µM 0.0530259836140097 0.481455011211006 no 1615 0.478855602451212 515 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3058 9093861 49.47 µM 0.0516781140440188 0.482011375974957 no 1616 0.479392588197763 525 17217477 SGTC_25 0118-0223 35.662 µM 0.0506009489134509 0.482456026375001 no 1617 0.479821753336104 522 5333628 SGTC_1685 st024049 53.0905 µM 0.0504571478809617 0.482515388655138 no 1618 0.479879048458657 521 1941139 SGTC_1120 ficusin 1.78878 µM 0.0502878910520713 0.482585259799451 no 1619 0.479946486551176 510 6199 A DNA cross-linker. SGTC_1711 st032263 62.8 µM 0.0500892247407083 0.482667272194861 no 1620 0.480025643186054 508 3958979 SGTC_26 0302-0163 425.158 µM 0.0499129784173547 0.482740029901252 no 1621 0.480095867457017 522 3100915 SGTC_2777 climbazole 1.536 µM 0.0487133344427899 0.483235280026616 no 1622 0.480573874571947 533 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_814 3342-0569 96 µM 0.0486296291721665 0.483269837124741 no 1623 0.480607228613661 527 4346283 SGTC_1027 k015-0025 8.67 µM 0.0477739658749501 0.48362309851317 no 1624 0.480948192540096 504 3598955 SGTC_325 2810-4341 181 µM 0.0476276182391164 0.483683519565911 no 1625 0.481006510414617 506 774970 SGTC_2137 5261020 140 µM 0.0472735498461526 0.483829701711883 no 1626 0.481147604335977 511 763655 SGTC_2608 thymoquinone 42.66 µM 0.0471802489574852 0.483868222666585 no 1627 0.481184784519154 525 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3259 9138485 49.47 µM 0.0462250285192398 0.484262611251513 no 1628 0.481565446959802 500 17646153 SGTC_296 1222-0039 74.9 µM 0.0461511878341404 0.484293099020883 no 1629 0.48159487372568 521 5984176 SGTC_2693 st077581 40.7 µM 0.0449739628637006 0.484779170761275 no 1630 0.482064031286636 527 25238761 SGTC_701 4424-0219 185 µM 0.0440206492132637 0.485172806971923 no 1631 0.482443972064337 516 2911779 SGTC_1516 st013856 110 µM 0.0424362664269705 0.48582705201293 no 1632 0.48307545897475 524 5281404 A mutagen and neurotoxin. SGTC_2760 etidronate 98.04 µM 0.0422444295069241 0.485906270565837 no 1633 0.483151922264192 535 3305 A chelator and antioxidant. SGTC_1745 st081495 74 µM 0.0411310508754051 0.48636604823368 no 1634 0.483595710261501 519 13842402 YBL026W LSM2 SGTC_1311 1190-0148 100 µM 0.0406945888482642 0.486546293327821 no 1635 0.483769687748712 529 1961333 SGTC_1844 rapamycin 4 nM 0.0390377282108203 0.487230549384329 no 1636 0.484430154382336 528 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3212 9128307 49.47 µM 0.0379834236691163 0.487665979431959 no 1637 0.484850449243222 502 27243542 SGTC_311 1315-0136 58 µM 0.0374891417674842 0.487870124016531 no 1638 0.48504749883828 526 6759207 SGTC_2738 aclarubicin 5.55 µM 0.0365760950378001 0.488247232011444 no 1639 0.485411502084778 525 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2978 9011784 42.97 µM 0.0363637570616216 0.488334933694365 no 1640 0.485496156364882 518 2994934 SGTC_3221 9128209 49.47 µM 0.0353693418978947 0.488745663155708 no 1641 0.48589261551523 536 16460723 SGTC_2193 5925765 200 µM 0.0342588883758351 0.489204334746067 no 1642 0.486335353967044 520 877370 SGTC_978 1416-0512 87.4 µM 0.0323483447234149 0.489993515747255 no 1643 0.487097127922086 533 6814003 SGTC_250 brefeldin a 552.239 µM 0.0310254271032664 0.490539991438305 no 1644 0.487624630767398 538 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1243 0416-0003 5.65 µM 0.0307555454773235 0.49065147735028 no 1645 0.487732246601407 529 2141977 SGTC_1989 st071868 50.2 µM 0.0301075651672048 0.490919155729021 no 1646 0.487990633668268 535 16414057 SGTC_67 0335-0847 266 µM 0.029963092080377 0.490978837613022 no 1647 0.488048244099283 523 4552207 YOR254C SEC63 SGTC_419 nsc-638432 893 µM 0.029659711556814 0.491104164871905 no 1648 0.48816922164721 504 368090 SGTC_2447 5741742 33.78 µM 0.0296414860535164 0.491111693901337 no 1649 0.488176489375614 534 1776504 SGTC_2965 9082772 38.63 µM 0.0295859078257164 0.491134653512508 no 1650 0.488198652160359 527 16459634 SGTC_3181 9108277 49.47 µM 0.0290811502781332 0.49134317241827 no 1651 0.488399934669311 531 17097298 SGTC_131 0141-0277 33.849 µM 0.0286293740314409 0.491529806382667 no 1652 0.488580092296276 530 1547771 SGTC_2561 acetosyringone 100 µM 0.0262145973440806 0.492527408851561 no 1653 0.489543086443541 536 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2470 5664817 21.68 µM 0.0256113658924472 0.492776625847846 no 1654 0.489783660186715 532 2859561 SGTC_1703 st026983 48.3 µM 0.0230406615212008 0.493838708358908 no 1655 0.490808919172673 530 1104023 SGTC_2066 5222451 176 µM 0.0225559132180213 0.494038986488847 no 1656 0.49100225551331 540 2281147 SGTC_2907 7721985 69.9 µM 0.0222936572683438 0.494147340527442 no 1657 0.491106854196495 539 3267881 SGTC_1272 0839-0021 27 µM 0.0216007342695188 0.494433631628982 no 1658 0.491383223903448 530 5027250 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0212702471228692 0.494570178165036 no 1659 0.4915150389121 535 65057 A dermal irritant. YDR527W RBA50 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0199121283037292 0.495131315177382 no 1660 0.492056735038298 540 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_996 3970-0799 1.8 µM 0.0195188759640199 0.495293797980219 no 1661 0.49221358953475 526 6615648 YGL040C HEM2 SGTC_1015 4130-4525 82 µM 0.0190662128855546 0.495480828895871 no 1662 0.492394142369771 530 1363237 SGTC_1123 mangostin 811.285 nM 0.0188464325189428 0.495571637906979 no 1663 0.49248180629815 539 5281650 An antioxidant. SGTC_2079 5212404 121 µM 0.0181986194042751 0.495839303116255 no 1664 0.492740202005358 532 758462 SGTC_1519 esterone 74 µM 0.0178487508010737 0.495983863577275 no 1665 0.492879756713808 538 698 A steroid. SGTC_119 0121-0043 24.815 µM 0.0154445848242168 0.496977242169852 no 1666 0.493838747057298 535 1092378 SGTC_1784 st039334 36.3 µM 0.0151544494215297 0.49709712475757 no 1667 0.493954480790073 541 3496984 SGTC_3295 9122362 53.5725 µM 0.0138145249219133 0.49765077850833 no 1668 0.494488977213821 533 4730473 SGTC_2720 fluspirilene 36.88 µM 0.0136179940241375 0.49773198503358 no 1669 0.494567374323226 531 3396 An atypical antipsychotic. SGTC_3225 9130819 49.47 µM 0.0132989155408882 0.497863828393794 no 1670 0.49469465669257 546 4547121 SGTC_1127 asiatic acid 681.4 nM 0.0125407052570949 0.498177122103613 no 1671 0.494997113580634 537 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_17 0960-0276 49.807 µM 0.0112469384038272 0.498711711140809 no 1672 0.49551321533745 544 6821114 SGTC_807 1315-0151 48 µM 0.0101143542654426 0.499179700842143 no 1673 0.495965025241102 544 4011080 SGTC_1433 4060-0023 7.6 µM 0.00998756687502662 0.499232090138418 no 1674 0.496015603536907 543 3840627 SGTC_2032 5185112 25.99 µM 0.00995459589833784 0.499245713942334 no 1675 0.496028756399673 542 5718189 SGTC_3054 9094397 49.47 µM 0.00897704583157982 0.499649643782124 no 1676 0.496418724965658 539 2598354 SGTC_482 fipronil 114 µM 0.00887836070985541 0.49969042112235 no 1677 0.496458093064218 546 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2646 retinol 96.75 µM 0.00826319384172069 0.499944612167387 no 1678 0.496703500119801 542 445354 A vitamin A analog and teratogen. SGTC_2020 4017018 200 µM 0.00799510606951223 0.499944612167387 no 1679 0.496810448132888 542 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2790 5423970 71.43 µM 0.00651320891682583 0.499332282636165 no 1680 0.497401623953341 544 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2239 6685329 187.64 µM 0.00645706381018657 0.499309083135164 no 1681 0.497424022139209 542 805680 SGTC_405 ebelactone b 50 µM 0.00557140489186318 0.498943123820717 no 1682 0.497777342526159 541 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_927 2425-1185 123 µM 0.00518690993432165 0.498784248570919 no 1683 0.497930731601181 543 730375 SGTC_2287 7945887 168.79 µM 0.00290793742122662 0.497842570477153 no 1684 0.498839902448895 547 1245853 SGTC_3314 9135860 59.4275 µM 0.0019955671676288 0.497465579501044 no 1685 0.499203884411846 548 25252478 SGTC_529 4076-0302 30.3 µM 0.00166450839081595 0.497328786706136 no 1686 0.499335957533452 543 5816522 SGTC_2884 9058502 51.95 µM 0.00144948399990891 0.497239939244293 no 1687 0.499421739750159 546 6471554 SGTC_2946 9065502 71.43 µM 0.00138958939955954 0.497215190991336 no 1688 0.499445634214528 547 16489101 SGTC_42 0133-0086 60.653 µM 0.00134700366960032 0.497197594713523 no 1689 0.499462623446845 546 162923 Model of phenazepam hydroxylation. SGTC_857 0438-0306 1.35 µM 0.00102644466659693 0.497065141008393 no 1690 0.499590507895908 548 4686136 SGTC_2089 5281248 129.67 µM 0.000786118313252218 0.496965839326403 no 1691 0.499686384199747 547 2737878 SGTC_2379 9035213 200 µM 0.000607951124849179 0.496892221630478 no 1692 0.499757462606821 548 646551 SGTC_2546 rhodinyl acetate 100 µM 0.000449884655478444 0.496826909528897 no 1693 0.49982052199568 545 6708682 SGTC_866 0495-0101 262 µM 7.60762116701849e-05 0.496672454500185 no 1694 0.499969649982661 548 635694 SGTC_613 3914-0030 117 µM 0 0.496641020403126 no 1695 0.5 543 1145395 SGTC_40 0327-0103 19.753 µM -9.51806679322882e-05 0.496601692523197 no 1696 0.499962028407342 549 409036 SGTC_2460 5552655 174.22 µM -0.00019387416127178 0.496560913207187 no 1697 0.499922655400476 549 5401989 SGTC_3063 1327-0034 4 µM -0.00144902177729368 0.496042300116784 no 1698 0.499421924150109 547 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3133 9127736 49.47 µM -0.00195747474717204 0.495832214836366 no 1699 0.499219081059244 549 27243420 SGTC_2224 6650123 117.647 µM -0.00214213866919276 0.495755914705946 no 1700 0.49914541096796 545 2908370 SGTC_277 nystatin 15.5 µM -0.00313064134649382 0.495347484178963 no 1701 0.498751056842242 552 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1531 st059297 52.4 µM -0.00335803335531804 0.495253530795258 no 1702 0.498660341033318 552 7566702 SGTC_105 0111-0055 734.78 µM -0.00428636601542797 0.4948699669166 no 1703 0.49828999260348 556 5179370 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.00667167118166257 0.493884440971882 no 1704 0.497338408029821 553 4174840 SGTC_2658 polymyxin b sulfate 77.05 µM -0.00704133259741492 0.4937317127949 no 1705 0.497190937928929 551 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_930 2810-3379 265 µM -0.00938996174355082 0.492761382775773 no 1706 0.496254002297525 562 1015764 SGTC_2773 thioridazine 9.09 µM -0.0101925423910569 0.492429808200125 no 1707 0.495933834299795 552 5452 An antipsychotic. SGTC_1153 4055-0057 267 µM -0.0105249264251583 0.492292490066882 no 1708 0.495801239370005 554 882706 SGTC_1441 4106-0040 13 µM -0.011163960962104 0.492028487698892 no 1709 0.495546316469075 547 2904180 SGTC_2376 9072922 81.32 µM -0.0120069536593048 0.491680230085115 no 1710 0.495210033619222 571 17087968 SGTC_3159 9100096 49.47 µM -0.0122296060668518 0.491588248846017 no 1711 0.495121214682092 552 25236875 SGTC_3109 9122853 49.47 µM -0.012648988864781 0.491414996382666 no 1712 0.494953918097464 570 1234709 SGTC_3309 9129340 25.759 µM -0.0127107321322768 0.491389489575496 no 1713 0.494929288077606 556 17158987 SGTC_2329 6138490 200 µM -0.013247359090876 0.491167804707482 no 1714 0.494715222928585 567 720019 SGTC_3251 9135047 49.47 µM -0.0139017885054222 0.490897458406149 no 1715 0.494454167423576 556 17682963 SGTC_1148 3909-7663 27.7 µM -0.0144370608561624 0.490676339265987 no 1716 0.494240646089576 569 4084526 SGTC_1680 diphenhydramine 100 µM -0.0151619660671643 0.490376888033573 no 1717 0.493951482426811 555 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1545 lovastatin 49.4 µM -0.0151979617733946 0.490362018700351 no 1718 0.493937123872109 555 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2109 5483026 200 µM -0.017571360195723 0.489381630863657 no 1719 0.492990402200993 554 759335 SGTC_500 h-89 112 µM -0.0177521567494268 0.489306951165189 no 1720 0.492918286060417 557 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_546 peri-Naphthalide 147 µM -0.0185374425050098 0.48898258596248 no 1721 0.492605053945901 555 223824 A penicillin ester. SGTC_2983 9022671 12.99 µM -0.0193512693931848 0.488646439430429 no 1722 0.492280442255185 553 6405161 SGTC_1979 st071809 45.3 µM -0.0204627160039973 0.488187375852697 no 1723 0.491837127081561 577 4976333 SGTC_450 aminopyrene 156 nM -0.0206457427894478 0.488111781325569 no 1724 0.491764125380876 556 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_708 3448-5400 146 µM -0.0209188904032439 0.487998965493095 no 1725 0.491655178779094 556 3462195 SGTC_799 1310-0557 151 µM -0.0224646990598679 0.487360531668268 no 1726 0.491038635479272 569 5354492 SGTC_517 1365-0151 113 µM -0.0232831556586511 0.487022514241469 no 1727 0.490712203954812 568 768657 SGTC_2305 7443522 69.23 µM -0.0233070190787977 0.487012658937756 no 1728 0.490702686410312 560 5415886 SGTC_210 3551-0445 56.827 µM -0.0240273906467721 0.486715157959535 no 1729 0.490415380217082 555 2865180 YOR207C RET1 SGTC_1727 st034309 9.9045 µM -0.0251728868645447 0.486242103157524 no 1730 0.489958531624465 592 870305 SGTC_1373 2887-0003 58.5 µM -0.0263302231775553 0.4857641784218 no 1731 0.489496974326836 563 776948 SGTC_1296 1068-0102 11.9 µM -0.0263560386893781 0.485753518076434 no 1732 0.489486679000575 561 767053 SGTC_400 oxethazaine 37.5 µM -0.0265851906338784 0.485658891739264 no 1733 0.489395292624004 576 4621 A local anesthetic. SGTC_1563 conessine 56.1 µM -0.0270384067879403 0.485471742384657 no 1734 0.489214550516481 556 441082 An anti-amoebic, histamine inhibitor. SGTC_2780 5215298 71.43 µM -0.0274260118222734 0.485311688773294 no 1735 0.489059975807562 570 2834131 SGTC_2127 5253358 187.912 µM -0.0274923072739441 0.485284313651869 no 1736 0.489033537718008 562 20612 SGTC_3086 9117350 49.47 µM -0.0275626889706749 0.485255251289161 no 1737 0.489005470119732 561 2679265 SGTC_2801 7907800 81.82 µM -0.0288463352180921 0.484725215547574 no 1738 0.488493573039844 567 6620925 SGTC_3025 9087895 49.47 µM -0.0291399900751144 0.484603965051523 no 1739 0.488376470930518 562 17173641 SGTC_2641 levomentholum 100 µM -0.0295697305684341 0.484426527177425 no 1740 0.488205103129845 557 16666 SGTC_838 0109-0203 71.4 µM -0.030066382875935 0.484221465566593 no 1741 0.488007055591 562 759422 SGTC_2654 protoveratrine a 100 µM -0.0303826243648081 0.48409089552831 no 1742 0.487880951103478 564 5702278 A heart drug and vasodilator. SGTC_1681 tripelennamine 100 µM -0.030808627699684 0.483915009630891 no 1743 0.487711079889068 560 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2021 4019055 173 µM -0.0335686418405562 0.482775547619623 no 1744 0.48661056417728 567 44827708 YER133W GLC7 SGTC_1836 st055642 81 µM -0.0343493291204973 0.482453268775227 no 1745 0.486299294553235 568 8571 SGTC_1358 1509-0022 2.48 µM -0.0348195978667798 0.482259140649046 no 1746 0.48611179663419 564 3258434 SGTC_614 0462-0418 107 µM -0.0354711791459309 0.481990173212597 no 1747 0.485852013808622 557 5188303 SGTC_2735 sertaconazole 140 nM -0.0357219115694822 0.481886675091016 no 1748 0.485752049397283 567 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3090 9117696 49.47 µM -0.0357974349962829 0.481855500531322 no 1749 0.485721939167127 556 7923821 SGTC_2247 cerulenin 830 nM -0.0360395009495073 0.481755581297148 no 1750 0.485625431098342 563 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_302 1094-0063 18.9 µM -0.0361112154472184 0.481725979428757 no 1751 0.485596839763979 560 5440289 SGTC_867 0518-0118 155 µM -0.0363639404336384 0.48162166197064 no 1752 0.485496083258383 566 6848158 SGTC_2254 7938975 95.19 µM -0.0373661578523919 0.481207988489853 no 1753 0.485096527969047 586 2969277 SGTC_125 0133-0007 11.75 µM -0.0384876492916491 0.480745107687068 no 1754 0.484649439313237 566 26541 SGTC_3205 9113483 49.47 µM -0.0384921208261268 0.480743262171723 no 1755 0.484647656749973 572 17018033 SGTC_1346 1488-2224 62.4 µM -0.0387200028617562 0.480649210040823 no 1756 0.484556812694707 568 3722427 SGTC_146 3448-8650 53.125 µM -0.0388635766129477 0.480589954420996 no 1757 0.484499578134622 569 2891488 YIL048W NEO1 SGTC_153 4077-0274 519.67 µM -0.0396703159998101 0.480257005734083 no 1758 0.484177983720347 557 3121976 SGTC_917 harmaline 728.087 nM -0.0404850453577682 0.479920773492791 no 1759 0.483853214671462 571 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1942 st076330 65.2 µM -0.0413014791073574 0.479583852194181 no 1760 0.483527776960479 595 24208414 SGTC_2361 9034121 116 µM -0.0413260597502605 0.479573708617381 no 1761 0.483517979067972 583 6496917 SGTC_1233 0325-0408 14.2 µM -0.0416190871074303 0.479452787434585 no 1762 0.483401178556445 577 12874 SGTC_1432 4049-0298 68.4 µM -0.0422820646796561 0.479179208944194 no 1763 0.483136921405676 570 741646 SGTC_1414 3917-0015 5.4 µM -0.0427604146116822 0.478981823355332 no 1764 0.482946259836095 566 6618702 SGTC_1950 st077106 7.18 µM -0.043010000093212 0.478878836824939 no 1765 0.48284678115493 564 13831864 SGTC_2301 7769476 200 µM -0.0432617290612614 0.478774967255462 no 1766 0.482746449214035 577 977820 SGTC_2155 5570423 76 µM -0.0437824542568223 0.478560107803252 no 1767 0.482538906573285 574 797402 SGTC_503 tyrphostin 8 294 µM -0.0438755095775747 0.478521712360429 no 1768 0.482501818511253 569 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1486 3970-0793 4.53 µM -0.0441042512260035 0.478427332394763 no 1769 0.48241065204784 577 2844330 SGTC_2593 nobiletin 86.24 µM -0.0454667570168959 0.477865180831033 no 1770 0.481867635770791 566 72344 An anti-infammatory. SGTC_2846 9008642 19.48 µM -0.0481498565284898 0.476758299860289 no 1771 0.480798406245657 579 2992898 SGTC_2472 5377652 49.4 µM -0.0482193996391407 0.476729613019461 no 1772 0.480770694746895 593 1610903 SGTC_2088 5278280 127.392 µM -0.0482612795292486 0.47671233743767 no 1773 0.480754006517178 572 791502 SGTC_225 nsc-122657 1.016 µM -0.0489198460885227 0.476440682509489 no 1774 0.480491586452394 590 275685 SGTC_220 paclitaxel 373.376 µM -0.0493953406473333 0.476244550530646 no 1775 0.48030212062806 597 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_877 0771-0151 33.1 µM -0.0496840155961424 0.4761254807025 no 1776 0.480187097216781 571 6166523 SGTC_1891 st059073 26.2 µM -0.05012902867866 0.475941930225325 no 1777 0.48000978363585 563 688754 SGTC_1097 itavastatin 7.23 µM -0.0502819376271229 0.475878862445919 no 1778 0.479948858623227 571 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3303 9125618 40.5795 µM -0.05127126831163 0.475470824548841 no 1779 0.479554681274126 581 22695467 SGTC_191 3914-0123 66.505 µM -0.0519687939791105 0.475183153662679 no 1780 0.479276779298724 578 3144412 SGTC_1405 3909-7894 12 µM -0.0529703623977912 0.474770113281943 no 1781 0.478877760964698 571 7104060 SGTC_2078 5212016 200 µM -0.0533657078836335 0.474607082783021 no 1782 0.478720263703224 570 1899708 SGTC_2892 9047358 58.44 µM -0.0541635491532419 0.474278086159892 no 1783 0.478402430797778 579 6466771 SGTC_3156 9099931 49.47 µM -0.05549726578718 0.473728156060542 no 1784 0.477871154090401 571 18111053 SGTC_2027 5150920 200 µM -0.0570943308617987 0.473069705706547 no 1785 0.477235026187809 572 786715 SGTC_1881 5652484 16 µM -0.0572998764498695 0.472984967086363 no 1786 0.477153159385883 600 2255129 SGTC_1161 k007-0610 110 µM -0.0574739381663838 0.472913209023588 no 1787 0.477083833056604 576 5843850 SGTC_2111 5486399 200 µM -0.0575336343202711 0.472888599102303 no 1788 0.477060057079198 576 689674 SGTC_1540 guanosine 70.6 µM -0.0588247659754928 0.472356351626282 no 1789 0.476545841108937 574 6802 Guanosine is a purine nucleoside SGTC_2640 pentamidine 10.38 µM -0.0619343762032852 0.471074671122652 no 1790 0.475307545891896 589 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2788 5282734 71.43 µM -0.0619650241962148 0.471062040482657 no 1791 0.475295342550968 576 743706 SGTC_3147 9097027 49.47 µM -0.0620097420094253 0.471043611445535 no 1792 0.475277536965882 579 25236841 SGTC_1206 3978-0017 132 µM -0.0621317476349907 0.470993330988313 no 1793 0.475228957436679 605 3873677 SGTC_1317 1273-0028 910 nM -0.062207353664868 0.470962172773862 no 1794 0.475198853228147 581 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3136 9095672 49.47 µM -0.0625159917933965 0.47083498088918 no 1795 0.475075963619801 564 17217380 SGTC_986 1493-0483 84 µM -0.0625172361370821 0.470834468092645 no 1796 0.475075468167635 575 40079 SGTC_398 bronopol 33.3 µM -0.0627718946789561 0.470729523814435 no 1797 0.474974073257938 593 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3007 9078383 71.4286 µM -0.063124146121559 0.470584365048129 no 1798 0.474833823407055 583 6496995 SGTC_63 0099-0242 26.702 µM -0.0633160606854899 0.470505280908178 no 1799 0.474757413423076 575 3898502 YLR359W ADE13 SGTC_2227 7312221 64.1025 µM -0.0657845728053253 0.469488161414009 no 1800 0.473774669373175 571 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_985 1493-0307 8.71 µM -0.0678475915439379 0.468638272814567 no 1801 0.472953479221846 582 3278274 SGTC_1590 st077108 57.8 µM -0.0680925608117664 0.46853736381252 no 1802 0.472855976112919 574 5489485 SGTC_1938 st074717 56.4 µM -0.0683966913954586 0.468412087589844 no 1803 0.472734927774213 572 17250979 SGTC_1215 3852-0577 11.2 µM -0.0690244599162423 0.468153509660892 no 1804 0.472485074865418 579 2884876 SGTC_2677 mitomycin C 100 µM -0.0692063345675531 0.468078597975492 no 1805 0.472412690471894 574 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1981 st071826 47 µM -0.0724181145213164 0.466755898315539 no 1806 0.471134584669817 574 11838600 SGTC_2482 5981709 142.65 µM -0.0726105499401195 0.466676659606922 no 1807 0.471058015622599 594 877755 SGTC_3354 9151612 71.43 µM -0.072789320080415 0.466603049003272 no 1808 0.470986884876821 581 27261949 SGTC_3024 9090631 49.47 µM -0.0729185814828396 0.466549824887334 no 1809 0.470935453710033 575 25236383 SGTC_557 1315-0110 16.2 µM -0.0730583570630333 0.466492272172206 no 1810 0.470879839655678 579 6833801 SGTC_878 0828-0289 13.7 µM -0.0740966225096275 0.466064787495467 no 1811 0.470466751361053 569 745350 YLR208W SEC13 SGTC_3121 9125696 49.47 µM -0.0741851151297565 0.466028354262967 no 1812 0.470431544809378 572 1235365 SGTC_779 1360-0071 233 µM -0.0762138234947699 0.465193194899508 no 1813 0.469624492559236 575 7566 SGTC_3162 9099653 49.47 µM -0.0763923928938566 0.465119690434699 no 1814 0.46955346075673 574 25237511 SGTC_1286 0929-0070 131 µM -0.0776692647055337 0.464594126928494 no 1815 0.469045571719247 588 1420408 SGTC_2649 anisomycin 9.56 µM -0.0781204116619141 0.464408448476749 no 1816 0.468866135326438 612 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_236 1509-0011 5.31 µM -0.0786310021423174 0.464198314219134 no 1817 0.468663063865591 596 3107280 SGTC_2993 9054257 71.4286 µM -0.0794203911176391 0.463873459708589 no 1818 0.468349125051334 585 6470217 YGL055W OLE1 SGTC_1564 D-Arginine 115 µM -0.0796821018352997 0.46376576410894 no 1819 0.46824504742516 613 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1244 0416-0015 52.5 µM -0.0796861694398907 0.463764090285106 no 1820 0.468243429829381 593 96201 SGTC_1230 0170-0365 3.77 µM -0.0797232208106009 0.463748843634188 no 1821 0.468228695348359 582 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2713 st079149 53.4 µM -0.0797333079977038 0.463744692762683 no 1822 0.468224683912754 580 3103253 SGTC_2031 5180455 200 µM -0.0800283572525622 0.463623281917328 no 1823 0.468107351235244 580 29949 SGTC_2950 9072895 21.46 µM -0.0804014258056961 0.463469771490659 no 1824 0.467958996474438 595 17332245 SGTC_3096 9117468 49.47 µM -0.0805058878004707 0.46342678839283 no 1825 0.467917456824563 594 41316311 SGTC_1179 1021-1431 9.29 µM -0.0813963286040836 0.463060415066687 no 1826 0.467563384386999 596 2840958 SGTC_2722 naftopidil 47.16 µM -0.0819483061614912 0.462833318708106 no 1827 0.467343910412331 596 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_945 3381-0768 11.3 µM -0.0824043061084898 0.46264571889619 no 1828 0.467162605959355 587 1126236 YIL048W NEO1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0824325692233574 0.462634091634879 no 1829 0.467151368838496 580 2333 A French combination drug. SGTC_1624 st003710 6.25 µM -0.0828017904437228 0.462482199366953 no 1830 0.467004572725216 612 24207033 SGTC_2876 9059903 25.97 µM -0.0832990421505011 0.462277645858441 no 1831 0.466806880951198 577 6916095 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0837042425700022 0.462110966691066 no 1832 0.466645791951479 593 7104 SGTC_1208 2323-2347 50.3 µM -0.0844134528576378 0.461819249115153 no 1833 0.466363855814378 583 5412760 SGTC_2729 fluphenazine 10.66 µM -0.0850654581265475 0.461551079644076 no 1834 0.466104675580186 585 3372 An atypical antipsychotic. SGTC_2023 5144124 124 µM -0.0853189717931498 0.461446814301182 no 1835 0.466003904607919 577 2830192 SGTC_80 0159-0065 512.242 µM -0.0883561213688205 0.460197900583027 no 1836 0.464796817460022 588 1548079 SGTC_369 0957-0393 4.5 µM -0.0889797022018171 0.459941524553918 no 1837 0.46454902071042 622 6997992 SGTC_2283 7944793 200 µM -0.0897797517052759 0.459612620448614 no 1838 0.464231119499313 579 2970533 SGTC_1034 k072-0165 12.7 µM -0.0898166693058103 0.459597444115161 no 1839 0.464216450769213 590 5835461 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.089853416543376 0.459582337874118 no 1840 0.464201849778933 586 1273210 SGTC_314 1671-0008 2.74 µM -0.0909485250241528 0.459132181993753 no 1841 0.463766746269274 596 3913060 SGTC_332 4112-0506 40.9 µM -0.0910071303012421 0.459108093148959 no 1842 0.463743462704682 583 2790355 SGTC_1721 st082152 9.2685 µM -0.0911357538170604 0.459055224854358 no 1843 0.463692361702071 600 5296051 SGTC_2364 9055074 200 µM -0.0920064500575385 0.458697360511213 no 1844 0.463346457463323 602 6470630 SGTC_884 0851-0618 334 µM -0.0922197552426505 0.458609695167387 no 1845 0.463261721256025 611 9642473 SGTC_2644 guaiazulene 100 µM -0.0924737426469281 0.458505312646193 no 1846 0.463160826073675 588 3515 A coloring agent. SGTC_1837 st055472 66.5 µM -0.0924965859295137 0.458495924763976 no 1847 0.4631517518139 603 676091 SGTC_367 0335-0881 7.1 µM -0.0943515940023752 0.457733651586035 no 1848 0.462414933293157 596 23828853 SGTC_3222 9128301 49.47 µM -0.095202684532607 0.457383967232899 no 1849 0.462076918862867 582 4911358 SGTC_43 0570-0105 72.5 µM -0.0952183175317853 0.457377544469269 no 1850 0.462070710402364 585 1114046 YDL195W SEC31 SGTC_2424 5537928 59.2 µM -0.0955097274576789 0.45725782174897 no 1851 0.46195498209444 595 5382802 SGTC_256 clotrimazole 625 nM -0.0965453404018754 0.456832382463109 no 1852 0.461543732824891 592 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2963 9082507 9 µM -0.0968512155387688 0.456706735596607 no 1853 0.461422275477148 601 16459611 SGTC_900 1112-0045 141 µM -0.0977928317439557 0.456319967324596 no 1854 0.461048399770085 585 56211 YIL048W NEO1 SGTC_3154 9100113 49.47 µM -0.0985235051843678 0.456019872157694 no 1855 0.460758304159087 603 25237525 SGTC_3198 9112019 49.47 µM -0.100060680697946 0.455388620326348 no 1856 0.460148075438435 603 45595555 SGTC_1261 0712-0010 12.7 µM -0.100424120287566 0.455239387728977 no 1857 0.460003810669534 602 2840123 SGTC_2061 5245884 80.95 µM -0.100709609283933 0.455122166996126 no 1858 0.459890491527583 605 573863 SGTC_2240 6690706 185.951 µM -0.102489022824455 0.45439163480776 no 1859 0.459184262742564 593 805876 SGTC_858 0438-0351 2.77 µM -0.102637092741953 0.454330852123674 no 1860 0.459125501267557 602 2799119 SGTC_2795 7780010 54.55 µM -0.103760292967786 0.45386981348654 no 1861 0.458679788973169 601 953673 SGTC_300 r073-0011 5.04 µM -0.103983861332439 0.453778053047898 no 1862 0.458591077962988 592 2735780 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.104363332920674 0.453622310010995 no 1863 0.458440509916308 599 229346 A bile salt which induces apoptosis. SGTC_1079 idarubicin 2.36 µM -0.104945770856914 0.453383279243529 no 1864 0.458209419788584 602 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_679 0422-0091 41.4 µM -0.105198488238527 0.453279570042835 no 1865 0.458109155139245 588 627384 YHR062C RPP1 SGTC_762 1165-0429 115 µM -0.105553891600586 0.453133726351974 no 1866 0.457968154733712 589 5967793 SGTC_2532 xanthone 78.9 µM -0.109113886304552 0.451673195266423 no 1867 0.456556080487251 612 7020 An insecticide. SGTC_1484 3473-2379 286 µM -0.10999453036221 0.451312000458308 no 1868 0.456206856366441 595 671917 SGTC_1255 0566-0045 221 µM -0.110485174841077 0.451110780843413 no 1869 0.456012303324666 619 2788469 SGTC_3258 9138477 49.47 µM -0.11069816045425 0.451023436609795 no 1870 0.45592785238027 582 4970355 SGTC_876 0720-0963 56.8 µM -0.111138204732969 0.450842984376744 no 1871 0.455753376694999 638 765861 SGTC_1239 0337-0584 35.4 µM -0.111259299570869 0.450793327896183 no 1872 0.455705364602423 610 914301 YML130C ERO1 SGTC_1865 st057639 52.2 µM -0.111905265702448 0.45052845428728 no 1873 0.455449260702494 593 688818 SGTC_2716 st080858 38.6235 µM -0.113494840818189 0.449876754886432 no 1874 0.454819126542839 583 5296050 SGTC_2874 9043904 71.43 µM -0.115419798819799 0.449087735166783 no 1875 0.454056193322828 608 4463428 SGTC_673 1082-0474 110 µM -0.116176636376261 0.448777570493988 no 1876 0.453756276412266 599 3098046 SGTC_1016 4226-1401 38 µM -0.116188890789904 0.448772548687596 no 1877 0.453751420493044 586 2901613 SGTC_1415 3966-0071 78.1 µM -0.116875851172986 0.448491048404775 no 1878 0.453479217475839 604 2893185 SGTC_2476 5806916 10.51 µM -0.116915978122693 0.44847460612043 no 1879 0.453463318140427 609 2870194 SGTC_1045 1348-1485 165 µM -0.116919851607103 0.448473018939132 no 1880 0.453461783369658 599 6810614 SGTC_1631 benzylvanillin 81.9 µM -0.117129452191478 0.448387135190467 no 1881 0.453378735447141 608 75506 SGTC_51 1013-0126 23.419 µM -0.117407068087866 0.448273385921493 no 1882 0.4532687416437 594 1627850 SGTC_526 4469-0568 170 µM -0.11946664555524 0.447429636001481 no 1883 0.45245283187129 602 2901964 SGTC_2607 solasodine 47.35 µM -0.119583825150675 0.447381637991425 no 1884 0.452406416713291 606 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2125 5246583 200 µM -0.119734886125991 0.447319762944498 no 1885 0.452346582007889 610 835267 SGTC_552 k242-0005 476 µM -0.121070289389561 0.446772833533894 no 1886 0.451817680834133 605 4088318 SGTC_1795 st049545 62.3 µM -0.121407760973478 0.446634634236792 no 1887 0.451684034993272 588 5291882 SGTC_2714 st079313 56.9 µM -0.122044540346031 0.446373881911848 no 1888 0.451431871902462 593 2939799 SGTC_3332 9141069 11.198 µM -0.122081623099153 0.44635869775192 no 1889 0.451417187824794 612 17332883 SGTC_1349 flufenamic acid 69 µM -0.122787239861124 0.446069786057242 no 1890 0.451137789455208 612 3371 A non-steroidal anti-inflammatory. SGTC_2529 gangaleoidin 93.61 µM -0.12279266494971 0.446067564889179 no 1891 0.451135641412608 588 4565183 SGTC_2761 levamisole 97.89 µM -0.123830164995428 0.445642817400439 no 1892 0.450724873705061 610 26879 An alkaline phosphatase inhibitor. SGTC_1733 st037357 54.9 µM -0.124894409314636 0.445207185752272 no 1893 0.450303572218303 619 1272339 YGL099W LSG1 SGTC_2139 5578692 56.4705 µM -0.126155210357056 0.444691182359275 no 1894 0.44980453248993 599 650991 YMR113W FOL3 SGTC_1447 4239-0816 81.9 µM -0.126636627373113 0.44449417926856 no 1895 0.449614002927691 612 1341554 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.127371941277518 0.444193304229769 no 1896 0.449323011476504 620 23847180 SGTC_1743 st037606 46.3785 µM -0.127603471892543 0.444098573403552 no 1897 0.449231391712005 609 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2016 5121758 140 µM -0.128055996377318 0.443913432089759 no 1898 0.449052329533833 613 2795203 SGTC_555 4296-0685 37 µM -0.128196543473809 0.443855932554304 no 1899 0.448996717704612 609 2908540 YHR072W ERG7 SGTC_2218 6965428 192.983 µM -0.128714900004802 0.443643876787122 no 1900 0.448791622494922 598 675684 SGTC_2348 9022543 33.42 µM -0.12921531281166 0.443439176970227 no 1901 0.448593639958145 621 3162678 YDL140C RPO21 SGTC_2977 9011197 71.43 µM -0.129448212651344 0.443343911661149 no 1902 0.448501500193915 595 2704722 SGTC_658 3253-0951 102 µM -0.12964245047658 0.443264463159696 no 1903 0.448424658008368 619 1184878 SGTC_903 1134-0042 114 µM -0.129683709194863 0.443247587526383 no 1904 0.448408335946976 604 701009 SGTC_932 2857-0803 154 µM -0.130129318503642 0.443065331055375 no 1905 0.4482320572609 630 674898 SGTC_716 1683-5115 658 µM -0.131595856810938 0.442465594698742 no 1906 0.447651981405624 616 723597 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.13175170234942 0.442401869867224 no 1907 0.447590344682194 599 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1686 st019653 115.5 µM -0.132591027423768 0.442058697714745 no 1908 0.447258414421381 619 97252 SGTC_940 3232-1287 54.8 µM -0.132663275515563 0.442029159897866 no 1909 0.447229843987536 617 1585493 YIL048W NEO1 SGTC_74 000s-0487 160.283 µM -0.133230912610904 0.441797099105799 no 1910 0.447005382019242 613 677548 SGTC_1856 st057054 55.7 µM -0.13326631309386 0.441782627379015 no 1911 0.446991384091039 624 1266018 SGTC_603 3794-0023 45.9 µM -0.133751534332899 0.441584276648794 no 1912 0.446799526364315 635 3802260 SGTC_3242 9133940 49.47 µM -0.134999039229931 0.441074383837726 no 1913 0.446306316980564 636 17248444 SGTC_3281 9140613 49.47 µM -0.135196271930315 0.440993777814168 no 1914 0.446228347300905 613 16013766 SGTC_3351 9150312 21.596 µM -0.13571122874149 0.440783334279874 no 1915 0.446024785299831 587 4904905 SGTC_2001 4023502 57.655 µM -0.13571774253158 0.440780672445149 no 1916 0.446022210494999 601 108941 YCR052W RSC6 SGTC_2887 9044784 58.44 µM -0.137339143406616 0.44011817687842 no 1917 0.445381365798982 612 6465546 SGTC_1568 digitonin 820 nM -0.138343854347801 0.439707741453228 no 1918 0.444984333972657 638 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1262 0737-0114 49.6 µM -0.138621964297622 0.439594141923482 no 1919 0.444874442942044 606 765919 SGTC_3000 9075062 71.4286 µM -0.139132033961711 0.43938580677669 no 1920 0.444672907479563 581 17057871 SGTC_91 0417-1751 58.384 µM -0.139154347669864 0.439376693248251 no 1921 0.444664091356089 601 6795624 SGTC_1456 k015-0012 13 µM -0.143867776500895 0.437452327759966 no 1922 0.442802440777457 629 2989616 SGTC_1085 doxorubicin 7.67 µM -0.144014933413252 0.437392271140691 no 1923 0.442744338703616 606 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_761 k216-0224 480 µM -0.144754759241788 0.437090360634735 no 1924 0.442452251399525 647 1340404 SGTC_248 streptozotocin 5.23457 mM -0.145051052102936 0.436969458753417 no 1925 0.442335282112282 625 5300 DNA alkylating agent. SGTC_128 0906-2981 13.371 µM -0.145328319862592 0.436856325369256 no 1926 0.442225828029953 627 6740226 SGTC_543 3844-1095 191 µM -0.146600794940264 0.436337184559325 no 1927 0.441723563095845 610 4230703 SGTC_1873 rapamycin 2 nM -0.146979451582077 0.436182722413726 no 1928 0.441574119710617 613 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1754 st042065 16.137 µM -0.147238847405424 0.436076914923153 no 1929 0.441471749466696 617 1126236 YIL048W NEO1 SGTC_471 1-acyl-paf 4 µM -0.14882655459512 0.43542938952976 no 1930 0.440845248223161 611 16759367 SGTC_2917 7979103 53.79 µM -0.14890923326721 0.435395674852647 no 1931 0.440812627677807 646 2980565 SGTC_769 0302-0231 76 µM -0.153933386683369 0.433347817805344 no 1932 0.438831129531885 618 571869 YER009W NTF2 SGTC_2703 st077852 53.4 µM -0.154244174333433 0.433221198179332 no 1933 0.43870860642149 636 6281836 SGTC_513 4245-1575 41.7 µM -0.154363995875215 0.433172382886867 no 1934 0.438661370243827 611 719745 SGTC_506 n9-isopropylolomoucine 153 µM -0.155888586393669 0.432551354027928 no 1935 0.438060421029103 628 6610355 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.15638974378811 0.432347248170007 no 1936 0.437862910489212 609 16623 A steroid. SGTC_837 0091-0265 12.5 µM -0.157876678216482 0.431741772357385 no 1937 0.437276987828333 617 759367 SGTC_2444 5485484 36.41 µM -0.158337299562565 0.431554241007116 no 1938 0.437095509021777 648 6790631 SGTC_258 haloperidol 50.781 µM -0.162712067315384 0.429773930097657 no 1939 0.435372572636018 607 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2033 5192550 145 µM -0.162864448294888 0.429711944197379 no 1940 0.435312581591894 612 182073 SGTC_743 1275-0778 158 µM -0.162982142100749 0.429664069614632 no 1941 0.435266247600248 640 2849257 YMR203W TOM40 SGTC_3209 9113616 49.47 µM -0.163149045195429 0.429596179828741 no 1942 0.435200542296804 647 16649353 SGTC_1658 st012944 20 µM -0.164933661902136 0.428870396654977 no 1943 0.434498098428078 657 24207260 SGTC_2438 5259590 200 µM -0.167610614453516 0.427782162287071 no 1944 0.433444810107564 629 1201127 SGTC_539 4859-0462 2.54 µM -0.167931232761843 0.427651861239218 no 1945 0.433318689422536 616 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_592 k241-0073 46.5 µM -0.169498332471355 0.427015097072018 no 1946 0.432702341939944 624 4230158 SGTC_2467 5474540 200 µM -0.170208898611511 0.426726433223308 no 1947 0.432422926877927 608 5413519 SGTC_2015 5119600 184 µM -0.170481546353824 0.426615681885503 no 1948 0.432315722899817 642 2828786 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.172090528772766 0.425962220559909 no 1949 0.431683179313757 636 390807 SGTC_810 3825-7150 143 µM -0.174493164290791 0.424986809176095 no 1950 0.430738951233131 621 22330411 YGL099W LSG1 SGTC_654 1124-0271 80.9 µM -0.174536421969219 0.424969251803545 no 1951 0.43072195471489 625 5403748 SGTC_1474 0330-0125 5.35 µM -0.174684504557267 0.424909149354469 no 1952 0.430663772064651 615 X1474 SGTC_649 1123-0311 367 µM -0.174831803569604 0.424849366667802 no 1953 0.430605898779714 624 693629 YIL048W NEO1 SGTC_1355 1499-0035 1.68 µM -0.175422707593066 0.424609560111558 no 1954 0.430373749576504 628 1548538 SGTC_1917 st066507 28.5 µM -0.176180765284942 0.424301958457465 no 1955 0.430075965749144 630 3156428 SGTC_2013 4024628 200 µM -0.177389345943736 0.423811640791986 no 1956 0.429601287658345 643 5230760 SGTC_3271 9137798 49.47 µM -0.1781706171 0.423494744059428 no 1957 0.429294492323983 617 6498326 SGTC_2441 5730946 39.09 µM -0.178764211780966 0.423254005131062 no 1958 0.429061423713748 613 1774275 SGTC_2174 5790901 200 µM -0.179595203839639 0.422917035201685 no 1959 0.428735185120905 630 786020 SGTC_3196 9111891 49.47 µM -0.180170223316586 0.422683895965089 no 1960 0.428509467112149 623 18891510 SGTC_184 1494-0393 24.714 µM -0.181742055994594 0.422046741410377 no 1961 0.427892579821907 639 3090647 SGTC_540 1187-0821 17.3 µM -0.182103348968727 0.421900317274263 no 1962 0.427750810290816 632 847520 SGTC_1225 1216-0074 20.6 µM -0.182266441316296 0.421834223050258 no 1963 0.427686816735021 622 4241466 SGTC_1024 4507-0395 26 µM -0.183288907982239 0.421419912091873 no 1964 0.427285668560186 620 4201836 SGTC_639 0833-0042 114 µM -0.184517357008596 0.4209222506479 no 1965 0.426803806002439 626 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_698 k064-0052 127 µM -0.184725980168437 0.420837747090097 no 1966 0.426721983815049 616 5088751 SGTC_357 1325-0123 420 µM -0.185128816649333 0.420674587055458 no 1967 0.426563999917446 671 1098503 SGTC_2386 9075165 157.42 µM -0.185160883414787 0.42066159970429 no 1968 0.426551424520161 623 16452277 SGTC_1060 3448-7350 82 µM -0.1858741660912 0.42037273564857 no 1969 0.426271720807798 648 570178 SGTC_1716 st033144 30.6155 µM -0.186518828412318 0.420111698238246 no 1970 0.426018957494867 647 674617 SGTC_2557 derrustone 83.84 µM -0.186928308570008 0.419945909301328 no 1971 0.425858421680254 688 629853 An antioxidant. SGTC_85 0868-0259 160.055 µM -0.188705935701866 0.419226354716739 no 1972 0.425161649579206 645 83173 SGTC_1409 3909-8004 61.9 µM -0.188724611506009 0.419218796483993 no 1973 0.425154330507312 618 2119279 SGTC_2492 derrusnin 100 µM -0.189275687762905 0.418995785373856 no 1974 0.424938374628263 651 1715307 Part of coumarin class of compounds. SGTC_1634 st006576 41 µM -0.190425157804681 0.418530698398977 no 1975 0.424487992631612 623 3915356 SGTC_3244 9134489 49.47 µM -0.192421782334594 0.417723115342523 no 1976 0.423705915684927 669 16584271 SGTC_1247 0448-0043 5.84 µM -0.192658148601998 0.417627534187986 no 1977 0.423613350950826 651 3089013 YGL099W LSG1 SGTC_2072 5231554 129 µM -0.193341686492507 0.417351154380751 no 1978 0.423345690539638 640 789545 SGTC_1435 4092-0789 56.7 µM -0.193710740419462 0.417201949108151 no 1979 0.423201190751619 622 2248285 SGTC_2322 7413319 38.22 µM -0.194232649166698 0.416990966327184 no 1980 0.422996859654029 629 1840400 SGTC_1472 k841-0093 193 µM -0.195258206762438 0.416576452059606 no 1981 0.422595406731201 653 X1472 SGTC_1614 st002383 48.6 µM -0.198615816899371 0.415220010032555 no 1982 0.421281640005884 640 1947235 SGTC_870 0573-2213 57.6 µM -0.199230317860804 0.414971866438282 no 1983 0.421041292275365 626 3916321 SGTC_2413 inermin 26.06 µM -0.200342655155626 0.414522776298878 no 1984 0.420606302359586 673 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1491 4138-0063 26.5 µM -0.200584858470414 0.414425004993943 no 1985 0.420511599317532 652 23883227 SGTC_3101 9120531 49.47 µM -0.204142169599861 0.412989623049516 no 1986 0.419121200779611 698 24824904 SGTC_3057 9095946 49.47 µM -0.204429639068848 0.41287367907133 no 1987 0.419008885292804 630 24540043 SGTC_1372 2752-0194 270 µM -0.204703138673749 0.412763376560734 no 1988 0.418902034015343 647 823334 SGTC_212 3807-4682 38.772 µM -0.205927068437006 0.41226984965006 no 1989 0.418423940505999 634 3125501 YBL034C STU1 SGTC_1476 4112-3294 3.34 µM -0.206514310431349 0.412033104428701 no 1990 0.418194593777283 622 704369 SGTC_3140 9094243 49.47 µM -0.206562643007437 0.41201362068956 no 1991 0.418175718779419 661 19291112 SGTC_374 0880-0231 82.3 µM -0.207942618783694 0.411457419074053 no 1992 0.417636885726056 652 6833587 SGTC_1187 1391-0724 117 µM -0.208270716588594 0.411325204822672 no 1993 0.417508797534969 643 6997986 SGTC_734 2023-0417 80 µM -0.209367861907678 0.410883159125054 no 1994 0.417080539631593 676 3935732 SGTC_2567 aureobasidin a 60 nM -0.210424912239332 0.410457374925644 no 1995 0.416668025370373 630 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2563 tomatine 8.54 µM -0.210955566163114 0.410243665103199 no 1996 0.41646097205307 691 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2049 5262831 67.185 µM -0.21202283387792 0.409813926015378 no 1997 0.416044610206925 662 763417 SGTC_758 0868-0029 16 µM -0.212389213164182 0.409666427058121 no 1998 0.415901700235532 627 762687 SGTC_3112 9123419 49.47 µM -0.216302385184359 0.408091842558907 no 1999 0.414376024982819 646 17015854 SGTC_112 phenothiazine 287.218 µM -0.219011423806709 0.407002645105571 no 2000 0.413320574439009 671 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2309 7664088 163.95 µM -0.219238009979357 0.406911576214323 no 2001 0.413232323973584 662 704922 SGTC_2357 9067248 200 µM -0.219634027289127 0.406752422114771 no 2002 0.413078094235074 673 9150235 SGTC_670 4204-0025 119 µM -0.220466091019544 0.40641807694651 no 2003 0.412754089068453 663 719039 SGTC_2434 5670830 169.91 µM -0.221062366563296 0.406178519640316 no 2004 0.412521936236708 659 1549830 SGTC_2147 5545932 89.7195 µM -0.22153078464278 0.405990354469829 no 2005 0.412339584653351 676 797404 SGTC_604 1000-0114 314 µM -0.222921974235637 0.40543163695125 no 2006 0.411798116858565 664 1572745 SGTC_1328 1441-0025 69.2 µM -0.223967715180528 0.405011782288945 no 2007 0.411391212333605 653 4562601 SGTC_1911 st060208 74.3 µM -0.226545833205916 0.403977161253365 no 2008 0.410388457965309 650 688783 SGTC_1483 3453-0561 55.9 µM -0.226615687604476 0.403949137389502 no 2009 0.410361296341129 653 4546991 SGTC_463 ikarugamyin 104 µM -0.227334986537637 0.40366060107566 no 2010 0.41008163494321 653 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1437 4092-1038 11.6 µM -0.227471883581082 0.403605692749368 no 2011 0.410028414933898 649 3977136 SGTC_1461 k072-0203 53.8 µM -0.228042676556178 0.403376772667727 no 2012 0.409806531683813 652 5418714 SGTC_2787 5284540 71.43 µM -0.229877015979649 0.402641323912929 no 2013 0.409093668341124 676 736958 SGTC_3213 9129884 49.47 µM -0.229950350921219 0.402611928595488 no 2014 0.409065175054467 664 17190742 SGTC_2465 5809242 33.21 µM -0.230088005470021 0.402556753122011 no 2015 0.40901169256332 651 2731748 SGTC_136 0097-0015 404.482 µM -0.232617020693876 0.401543405448576 no 2016 0.408029404618432 647 4861337 SGTC_2696 st077691 74.316 µM -0.233246881522963 0.401291130031871 no 2017 0.407784851706796 680 757133 SGTC_1270 0831-1170 17.3 µM -0.233578599029823 0.401158285195772 no 2018 0.407656071847109 640 6764716 SGTC_1344 1488-0097 29.1 µM -0.235345593435839 0.400450839582898 no 2019 0.406970255131871 647 747966 SGTC_1304 1165-0502 251 µM -0.235785324618969 0.400274836526511 no 2020 0.406799628196413 643 767425 SGTC_2852 9023854 51.95 µM -0.235997387987526 0.400189965085305 no 2021 0.406717348511335 676 19798528 SGTC_1849 st056239 19.2 µM -0.236185739513499 0.400114587487403 no 2022 0.406644272373032 655 5393181 SGTC_2313 7726885 200 µM -0.236323306227919 0.400059536138191 no 2023 0.406590901648736 646 726423 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.236412258402673 0.400023940377838 no 2024 0.406556392465644 648 5106787 A p450 inhibitor. SGTC_507 nimesulide 162 µM -0.237748717486087 0.399489233175417 no 2025 0.406037997860595 664 4495 A COX2 inhibitor. SGTC_1738 st035555 74 µM -0.237778688028164 0.399477244344507 no 2026 0.406026374572894 695 5331140 SGTC_3131 9127911 49.47 µM -0.238389325929567 0.399232997327711 no 2027 0.405789572748886 687 45595681 SGTC_2456 5770359 74.46 µM -0.238880478748441 0.399036571365476 no 2028 0.405599131552134 661 3118787 SGTC_347 4534-1311 26.2 µM -0.239685956374136 0.398714493345148 no 2029 0.405286861414946 653 2862016 SGTC_819 1013-0258 27.7 µM -0.24026242568055 0.398484028843429 no 2030 0.405063410952578 680 5753198 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.240401466955382 0.398428447349572 no 2031 0.40500952054074 676 15053 SGTC_1375 2910-0797 186 µM -0.240565876367002 0.398362727648408 no 2032 0.404945800125806 651 742508 SGTC_262 fenpropimorph 62.5 µM -0.241010358482242 0.398185068364637 no 2033 0.404773544112649 659 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2912 7964298 10.93 µM -0.241596081231212 0.39795098750371 no 2034 0.404546579438617 641 2975850 SGTC_2617 dihydrotanshinone i 20.83 µM -0.241602007265888 0.397948619384232 no 2035 0.404544283293414 623 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1021 4476-0760 85.3 µM -0.241620355532269 0.397941287205449 no 2036 0.404537173959331 653 746768 SGTC_3194 9111903 49.47 µM -0.245840778376016 0.396255720270864 no 2037 0.402902744486696 678 17087251 SGTC_1412 3909-8563 178 µM -0.246206532125145 0.396109735066738 no 2038 0.402761179634363 663 23767530 SGTC_3070 9117005 49.47 µM -0.248014552395485 0.395388304866842 no 2039 0.4020615736611 656 8779016 SGTC_1597 7-benzyloxygramine 47.5 µM -0.248607236655473 0.395151891846904 no 2040 0.401832305090241 667 260807 SGTC_3239 9133757 49.47 µM -0.250431959864764 0.39442427928812 no 2041 0.401126658233021 674 17036923 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.250619106117995 0.394349675067418 no 2042 0.401054304260533 660 1377 SGTC_2336 9001819 198.65 µM -0.250854970861606 0.394255655166102 no 2043 0.400963119712449 668 2989602 SGTC_3050 9093513 49.47 µM -0.251268245765909 0.39409093126302 no 2044 0.400803361980255 647 25236664 SGTC_741 4582-0002 126 µM -0.251608337341658 0.393955391118387 no 2045 0.400671906823942 628 2912688 SGTC_3157 9099274 49.47 µM -0.253034949188233 0.393386969151971 no 2046 0.400120603113769 635 17217662 SGTC_121 0557-0495 61.343 µM -0.253437980819388 0.393226425555451 no 2047 0.399964890489708 666 3104427 SGTC_47 0149-0135 24.25 µM -0.254095790615223 0.392964432649853 no 2048 0.399710777639822 651 5239155 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.254175344989921 0.392932750966349 no 2049 0.399680048549621 657 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1830 st055982 50.3 µM -0.254211606397623 0.392918310481742 no 2050 0.399666042234161 688 455313 An antimicrobial agent. SGTC_2992 9074591 71.4286 µM -0.254852865690299 0.392662964314719 no 2051 0.39941837104679 661 17741321 SGTC_1191 1487-1166 10.6 µM -0.25720232741417 0.391727816125716 no 2052 0.398511293709146 675 3955771 SGTC_1921 5740136 50 µM -0.257220497431221 0.391720586405755 no 2053 0.398504280780238 693 1774243 SGTC_1092 toremifene 6.32 µM -0.257644462348377 0.391551904415219 no 2054 0.398340655910488 704 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1289 0976-0073 69.1 µM -0.257855173677148 0.391468076744588 no 2055 0.398259340701832 687 3391136 SGTC_1825 st052143 62.6 µM -0.258712199607168 0.391127176539164 no 2056 0.3979286530163 685 674173 SGTC_1668 st014914 51.6 µM -0.259135672354041 0.390958762143452 no 2057 0.397765281014946 650 2839556 SGTC_251 melphalan 456.522 µM -0.261103538676527 0.390176413791247 no 2058 0.397006331422928 675 460612 A DNA alkylator. SGTC_268 camptothecin 39.6153 µM -0.261259743266826 0.390114331827613 no 2059 0.396946104458546 671 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_350 k064-0020 19.8 µM -0.262042132896618 0.389803421039128 no 2060 0.396644479706884 671 2790705 SGTC_1040 k898-0338 155 µM -0.263179104609666 0.389351729957862 no 2061 0.396206267684351 692 20969351 SGTC_2881 9058953 51.95 µM -0.263485818727016 0.38922990550524 no 2062 0.396088076257632 638 17122249 SGTC_2132 5317594 122.667 µM -0.264258169155471 0.388923182196874 no 2063 0.395790495512913 657 794577 SGTC_3236 9132701 49.47 µM -0.264471487627819 0.388838479283005 no 2064 0.395708316224201 688 24282524 SGTC_1137 ixabepilone 100 µM -0.265370395377498 0.388481605764661 no 2065 0.395362069949762 631 154225 A novel microtubule stabilizer. SGTC_1055 3448-0672 86 µM -0.265416403304779 0.388463342781262 no 2066 0.395344350580455 691 748378 SGTC_2495 cafestol 54.53 µM -0.266545689974409 0.388015146480969 no 2067 0.3949094880734 693 16667697 An anti-infammatory. SGTC_1859 st055998 20 µM -0.266632343676766 0.38798076112842 no 2068 0.394876125111566 684 676301 SGTC_1507 4075-3230 155 µM -0.266680631789744 0.387961600137908 no 2069 0.394857533805647 670 659771 SGTC_3019 9081971 49.47 µM -0.267603763634225 0.387595348815491 no 2070 0.394502166817601 680 16451803 SGTC_2190 6049624 200 µM -0.268254163547631 0.387337363549294 no 2071 0.394251842859659 654 2265554 SGTC_2955 9076254 12.21 µM -0.268374739859895 0.38728954165025 no 2072 0.394205440607637 658 16459619 SGTC_3032 9089427 49.47 µM -0.269344508194715 0.386904983059003 no 2073 0.393832292320004 656 17173707 SGTC_3093 9117344 49.47 µM -0.269961644214625 0.386660317475933 no 2074 0.393594880916833 650 24824913 SGTC_1877 wortmannin 25 µM -0.270235226100133 0.386551869451388 no 2075 0.393489646978375 676 312145 A covalent inhibitor of PI 3-kinase. SGTC_247 mechlorethamine 29.705 µM -0.270920512539549 0.386280260401468 no 2076 0.393226084047171 658 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1207 2099-0101 141 µM -0.271741666467009 0.38595487450102 no 2077 0.392910330580494 701 5837381 SGTC_1386 3228-0095 33.8 µM -0.272022602940262 0.385843570577296 no 2078 0.392802319903196 708 870181 SGTC_97 0535-0701 19.132 µM -0.273854083382939 0.385118188996374 no 2079 0.392098379588916 657 2832013 YGL099W LSG1 SGTC_1431 4049-0260 9.09 µM -0.274049903787105 0.385040655519156 no 2080 0.392023135710391 669 3854841 SGTC_53 0973-0023 39.979 µM -0.27410845382211 0.38501747400712 no 2081 0.392000638676883 690 674768 SGTC_484 loperamide 105 µM -0.27647616962591 0.384080377702128 no 2082 0.391091180241883 643 3955 An opioid-receptor agonist. SGTC_1033 k072-0102 21.3 µM -0.277019701441706 0.383865353664935 no 2083 0.390882489179268 680 5965931 SGTC_1397 3532-0190 20.1 µM -0.278478506412259 0.383288419672119 no 2084 0.390322531074053 653 5322280 SGTC_2909 7941780 10.49 µM -0.279473668947797 0.382894997206236 no 2085 0.389940671216553 683 1243215 SGTC_2406 ethylparaben 405.7 µM -0.279540093711208 0.382868741475794 no 2086 0.389915186743975 701 8434 A possible steroid mimic. SGTC_3022 9087993 49.47 µM -0.280050564668492 0.382666985480958 no 2087 0.389719355656528 652 17173644 SGTC_3103 9120822 49.47 µM -0.280072151906055 0.382658454150161 no 2088 0.389711074798653 690 17141819 SGTC_92 0063-0024 660.874 µM -0.280467805375199 0.382502100989595 no 2089 0.389559311117681 675 3594437 SGTC_1301 naphtanilide LB 4.81 µM -0.281377450774498 0.382142702698094 no 2090 0.389210455711985 687 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_460 trequinsin 123 µM -0.281712072977083 0.382010519950973 no 2091 0.389082148192568 654 5537 A vasodilator. SGTC_3110 9122132 49.47 µM -0.281855090646374 0.381954029183752 no 2092 0.389027313193643 648 918317 SGTC_2400 5203494 178.7 µM -0.282036789283064 0.381882263387269 no 2093 0.388957650552339 655 6777674 SGTC_2953 9074162 66.49 µM -0.283051161922992 0.381481689677067 no 2094 0.388568809175083 654 16451992 SGTC_2333 9017922 200 µM -0.284111699089193 0.381063021397523 no 2095 0.388162390832664 656 3163164 SGTC_1798 st045719 60.953 µM -0.284483465225921 0.380916292194318 no 2096 0.38801995182442 643 3980186 SGTC_2870 9038528 12.99 µM -0.284610476236001 0.380866167226051 no 2097 0.387971292096147 682 6463316 SGTC_2961 9083290 32.55 µM -0.28485580726057 0.380769352857254 no 2098 0.387877307264595 691 17741490 SGTC_780 0109-0199 192 µM -0.285612946310221 0.380470612062497 no 2099 0.387587293309827 670 610414 SGTC_3197 9113331 49.47 µM -0.286071466015441 0.380289730736459 no 2100 0.387411692754493 683 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2899 9053889 58.44 µM -0.286400422689107 0.380159976822143 no 2101 0.387285725497777 687 6470052 SGTC_2856 9022925 19.48 µM -0.28691998033191 0.379955069596025 no 2102 0.387086795661004 674 4944862 SGTC_3120 9124077 49.47 µM -0.286969901295221 0.379935383147657 no 2103 0.387067683328871 675 18774327 YGL155W CDC43 SGTC_3284 9108171 64.8615 µM -0.287170078189163 0.379856446047967 no 2104 0.386991047989403 688 8687505 SGTC_2304 7443016 91.4 µM -0.287419988606425 0.379757904219765 no 2105 0.386895378946165 681 939854 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.287880893403231 0.379576185975001 no 2106 0.386718956465349 693 5024745 SGTC_3340 9146634 11.102 µM -0.28904745858847 0.379116370053713 no 2107 0.386272530044708 693 4907387 SGTC_1787 fluconazole 80 µM -0.289150589781037 0.379075727851083 no 2108 0.386233070568146 681 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3302 9125395 16.351 µM -0.289338223288305 0.379001788190006 no 2109 0.386161282309585 676 17599668 SGTC_320 4092-0846 5.34 µM -0.289756320280113 0.378837047031196 no 2110 0.386001333137188 661 1359356 SGTC_404 fumagillin 50 µM -0.290172623590215 0.378673034498152 no 2111 0.38584208941571 678 12015870 A methionine aminopeptidase binder. SGTC_544 k015-0020 52.4 µM -0.290294834175759 0.378624890895352 no 2112 0.385795345255845 646 3008304 SGTC_94 0334-0113 514.748 µM -0.290304505496712 0.378621081058387 no 2113 0.38579164615631 667 6795178 SGTC_2419 paclitaxel 166.5 µM -0.291604292296175 0.378109161698361 no 2114 0.385294596615499 665 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2966 9084041 48.03 µM -0.291908766750905 0.377989275718052 no 2115 0.385178190192041 675 17741380 SGTC_286 k060-0067 22.9 µM -0.292624471159691 0.377707515358409 no 2116 0.384904603429015 660 5985051 SGTC_1677 st019204 53.9 µM -0.29461712615864 0.37692338494348 no 2117 0.384143188898476 684 3945625 SGTC_1425 4048-4433 7.33 µM -0.295163559563802 0.376708446235026 no 2118 0.383934468877465 693 23734946 SGTC_1057 3448-5381 134 µM -0.295442839131005 0.376598606814254 no 2119 0.383827806042193 671 5497911 SGTC_1660 st012960 28.1 µM -0.296322977915793 0.376252517503517 no 2120 0.383491719835501 711 24207266 SGTC_1197 1601-0112 267 µM -0.296756682381369 0.376082012242856 no 2121 0.383326139436493 680 7350313 SGTC_833 3852-0053 558 µM -0.298209595901992 0.375510994617825 no 2122 0.382771599170133 702 3123681 SGTC_1329 1447-1697 50.6 µM -0.298284041973541 0.375481743484558 no 2123 0.382743191451942 675 2840515 SGTC_1481 3346-2004 36 µM -0.302070496403801 0.373994928360537 no 2124 0.381299161472737 705 2770522 SGTC_2133 5320837 200 µM -0.302175287859065 0.373953806760759 no 2125 0.381259220823618 701 2841355 SGTC_2073 5212005 126 µM -0.303674835277065 0.373365521195108 no 2126 0.380687815843462 704 691789 SGTC_2383 9036125 200 µM -0.304787004061005 0.37292939812272 no 2127 0.380264190076162 685 79580 SGTC_677 0929-0063 136 µM -0.306128336077649 0.372403628170395 no 2128 0.379753466934517 678 1539583 SGTC_671 0560-0003 407 µM -0.308423065177831 0.371504701126052 no 2129 0.378880216687641 684 3238678 SGTC_1702 st027038 51 µM -0.308467785169429 0.371487189655463 no 2130 0.378863204792432 692 5521182 SGTC_2045 5106652 78.05 µM -0.308871506993509 0.371329112159882 no 2131 0.37870963593148 680 673349 SGTC_305 1682-2595 20.8 µM -0.309456292178168 0.371100177699296 no 2132 0.378487227634201 694 226033 SGTC_1966 st070145 16.1 µM -0.310733100202702 0.370600485477218 no 2133 0.378001765856635 673 3748532 SGTC_923 1900-2434 73.3 µM -0.311103195952275 0.370455685376418 no 2134 0.37786108580579 710 5910570 SGTC_836 0330-0104 1.35 µM -0.311145375436468 0.370439183802006 no 2135 0.377845053653044 671 46494820 SGTC_2159 5658611 73.75 µM -0.311246757695291 0.370399521729637 no 2136 0.377806519764192 702 793844 SGTC_816 0325-0417 81.3 µM -0.311499518646057 0.370300644322916 no 2137 0.377710454381223 687 68101 SGTC_2187 6125751 200 µM -0.311576649178617 0.370270473381718 no 2138 0.377681141334653 687 874498 SGTC_3111 9122088 49.47 µM -0.312360273645956 0.369963990400078 no 2139 0.377383369007074 696 16876704 SGTC_354 2783-3500 4.88 µM -0.312582648538314 0.369877032496117 no 2140 0.377298881226116 681 6740761 SGTC_2484 5809818 12.04 µM -0.31372674596306 0.369429747701462 no 2141 0.376864292635354 685 2870548 SGTC_771 0250-0039 27.3 µM -0.314696738551308 0.369050667536205 no 2142 0.376495960397008 690 3005115 SGTC_1091 telmisartan 47.6 µM -0.31659224982261 0.368310255754094 no 2143 0.375776508628076 700 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1778 st046819 58.9 µM -0.318164845862004 0.367696349769312 no 2144 0.37517994860384 674 671715 SGTC_2401 5128683 200 µM -0.318436844044429 0.36759020205115 no 2145 0.375076797067453 735 708373 SGTC_725 1497-0963 19 µM -0.319601765354835 0.367135704193046 no 2146 0.37463511797791 688 3549977 SGTC_2171 5739187 198.077 µM -0.319660111422464 0.367112945173312 no 2147 0.374613000426785 672 2262761 SGTC_2618 avocadyne 43.43 µM -0.320529606087005 0.366773837219422 no 2148 0.374283445421126 680 3015189 SGTC_272 doxorubicin 8.13 µM -0.320554034074832 0.366764311662727 no 2149 0.374274188074607 676 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_145 3737-0113 38.366 µM -0.320633451843927 0.366733343716592 no 2150 0.374244092039836 682 6849351 SGTC_2002 4023503 131 µM -0.320691100566342 0.366710864875894 no 2151 0.374222246049317 726 4736863 YCR052W RSC6 SGTC_2188 6126565 140.678 µM -0.32124922971549 0.366493258440122 no 2152 0.374010763831723 701 874518 SGTC_127 0180-0333 59.125 µM -0.321633254561227 0.366343557655962 no 2153 0.373865273959402 673 771601 SGTC_1581 himbacine 57.9 µM -0.321898800176287 0.366240054404612 no 2154 0.373764681086421 719 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1471 k673-0312 37 µM -0.322198178784722 0.366123375541152 no 2155 0.373651282052734 682 24099884 SGTC_2018 5133068 143 µM -0.322316780665875 0.366077155445071 no 2156 0.373606360896364 724 785362 SGTC_994 3910-0338 138 µM -0.322345050731812 0.36606613866238 no 2157 0.373595653696911 679 3479481 SGTC_1607 st000305 50.6 µM -0.324966264515017 0.365045138253373 no 2158 0.372603302093256 717 5457690 SGTC_2229 7354935 190 µM -0.325242059445102 0.364937767631595 no 2159 0.372498939356041 713 318112 SGTC_2674 ligustilide 100 µM -0.325840950113806 0.364704648032864 no 2160 0.372272347167353 670 5319022 A signalling regulator. SGTC_862 0452-0056 10.2 µM -0.326207176550586 0.364562118171302 no 2161 0.37213380601108 694 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3318 9139014 38.6185 µM -0.326554445370491 0.364426983623207 no 2162 0.372002451688747 703 16643984 SGTC_618 k072-0232 33.2 µM -0.326968919584153 0.364265719141527 no 2163 0.371845696446272 724 5872756 YGL099W LSG1 SGTC_190 3970-0790 3.722 µM -0.327061058426567 0.364229872834071 no 2164 0.371810852177795 690 2832352 SGTC_2117 5521686 200 µM -0.327096015687554 0.364216273139744 no 2165 0.371797632618697 687 803312 SGTC_739 1486-1183 203 µM -0.327691934164154 0.363984464665579 no 2166 0.371572301283547 692 4346692 SGTC_2947 9072639 7.68 µM -0.328985962600183 0.363481267337765 no 2167 0.371083149116 701 16488146 SGTC_3234 9132280 49.47 µM -0.329267672910793 0.363371752333928 no 2168 0.370976688138627 682 17612295 SGTC_2522 biochanin a 4.94 µM -0.329803719801876 0.363163394721449 no 2169 0.370774138252158 711 5280373 A possible chelator. SGTC_1726 st035556 14.5795 µM -0.330320552773628 0.36296254375821 no 2170 0.370578882411847 698 5919439 SGTC_1348 1493-0373 93.8 µM -0.331644374090062 0.362448254039539 no 2171 0.370078904222463 720 3010129 SGTC_3138 9097216 49.47 µM -0.333885469127299 0.36157817975656 no 2172 0.369232992577581 706 25237486 SGTC_1706 st031321 9.9705 µM -0.334022386657659 0.361525046549848 no 2173 0.36918133289571 683 6103185 SGTC_2367 9070478 135.38 µM -0.334953866346595 0.361163640732342 no 2174 0.368829943616526 662 572802 SGTC_1340 1486-1359 257 µM -0.335055528437749 0.361124204239834 no 2175 0.368791599470328 687 4309068 SGTC_2810 7959871 45.46 µM -0.335387761731837 0.360995335465054 no 2176 0.368666299314915 692 2974535 SGTC_527 4476-4215 268 µM -0.335470352467676 0.360963302090274 no 2177 0.368635152790673 670 4418754 SGTC_1672 st016598 6.51 µM -0.336235651590499 0.360666522067326 no 2178 0.368346585127372 716 4665860 YNL267W PIK1 SGTC_2819 7996655 46.38 µM -0.33739587953416 0.36021675024399 no 2179 0.36790924520153 707 6456960 SGTC_1811 st050069 61.5 µM -0.338474604317181 0.359798747263887 no 2180 0.367502780871557 693 3877702 SGTC_3341 9147222 25.867 µM -0.33927799448518 0.359487544599691 no 2181 0.367200159219042 713 1939759 SGTC_2506 ethyl hematommate 54.16 µM -0.340967065910074 0.358833566916012 no 2182 0.366564187625509 693 3940691 An allergen. SGTC_1314 1222-0010 41.1 µM -0.341550349978061 0.358607825927832 no 2183 0.366344653646763 699 3526027 SGTC_2518 prenyletin 46.28 µM -0.342004680067696 0.358432026565594 no 2184 0.366173685112767 692 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2150 5556613 200 µM -0.342154977932448 0.35837387662132 no 2185 0.366117132508649 691 743190 SGTC_1335 1486-0900 202 µM -0.345842961188849 0.356948035254723 no 2186 0.364730368353575 667 X1335 SGTC_2237 6667747 47.222 µM -0.345892980365201 0.3569287106066 no 2187 0.364711572137085 698 729940 YDL015C TSC13 SGTC_2951 9072950 58.06 µM -0.346230629377265 0.356798271275703 no 2188 0.364584698830028 702 16488155 SGTC_1875 nocodazole 6 µM -0.346551043387258 0.356674505589389 no 2189 0.364464315376041 694 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_319 1348-1596 45.5 µM -0.347749294703712 0.356211793236436 no 2190 0.364014236282415 728 5380505 SGTC_185 k048-0037 25.491 µM -0.34806700313113 0.356089143579863 no 2191 0.363894932206912 708 6827589 SGTC_2306 7482397 179.52 µM -0.349337086505006 0.355598983465401 no 2192 0.3634181295559 740 891448 SGTC_1310 1188-0297 994 nM -0.350387982861 0.355193594066706 no 2193 0.363023771889135 695 1588352 SGTC_1211 1056-0033 32.3 µM -0.35084374625517 0.355017831584883 no 2194 0.362852787968726 717 6741922 SGTC_176 1486-1328 72.834 µM -0.352390817646883 0.354421442835453 no 2195 0.362272593684117 680 22310231 SGTC_44 0929-0055 61.211 µM -0.352646720901497 0.354322827683313 no 2196 0.362176653378224 667 1379590 SGTC_1561 5-methoxyflavone 52.9 µM -0.352901266628933 0.354224745358459 no 2197 0.362081230609626 694 94525 SGTC_545 4218-0007 221 µM -0.354163289641706 0.353738601782664 no 2198 0.361608256736247 719 2840508 SGTC_1744 st037937 38.9 µM -0.354958622284701 0.353432354304372 no 2199 0.361310294976877 721 1016152 SGTC_781 4335-2806 94.4 µM -0.355228390653598 0.353328499954176 no 2200 0.361209248612697 735 845254 SGTC_1442 4112-3290 3 µM -0.356155147980761 0.352971803858365 no 2201 0.360862189587659 711 704353 SGTC_1980 st071811 45.7 µM -0.356915227574365 0.352679356115124 no 2202 0.360577634765379 733 4974850 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.357907973567791 0.352297518897602 no 2203 0.360206091715368 682 6708739 YPR165W RHO1 SGTC_235 0330-0087 5 mM -0.358108823949079 0.352220284445953 no 2204 0.360130937912568 698 46494818 YHR062C RPP1 SGTC_2244 6635614 200 µM -0.35829284983135 0.352149524990872 no 2205 0.360062084212962 671 836499 SGTC_1904 st060225 78 µM -0.360335617436559 0.351364408415711 no 2206 0.359298083446231 670 66595 SGTC_1446 4239-0190 62 µM -0.36128519231111 0.350999664718722 no 2207 0.358943131029204 716 1340085 SGTC_1159 4092-0538 61.2 µM -0.36252693975935 0.350522900963124 no 2208 0.35847914784545 692 717301 SGTC_467 ro 31-8220 72.8 µM -0.36302267493662 0.350332631204842 no 2209 0.358293972989715 700 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1046 2001-0062 216 µM -0.363091190574947 0.350306336943841 no 2210 0.358268382563274 715 739778 SGTC_2854 9024559 71.43 µM -0.364336061256522 0.349828717710798 no 2211 0.357803537318522 730 3163529 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.36480352482977 0.349649427380239 no 2212 0.357629036868701 689 688662 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.36583668513434 0.349253289499728 no 2213 0.357243471911763 698 88881 An O-methylated flavonoid and antioxidant. SGTC_2845 9003024 42.97 µM -0.366045483666078 0.349173251176144 no 2214 0.357165568102532 691 2990173 SGTC_2378 9074213 121.43 µM -0.366933626724119 0.348832876063529 no 2215 0.356834263907114 693 657714 SGTC_1974 st069448 26.9 µM -0.368171545747041 0.34835865450328 no 2216 0.356372662851867 716 6323587 YNR016C ACC1 SGTC_2580 diallyl disulphide 81.36 µM -0.368536298247305 0.348218970411156 no 2217 0.35623669231818 657 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.368931785240223 0.348067539628398 no 2218 0.356089285392633 725 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1145 3546-0597 10.2 µM -0.37030826607925 0.347540678257384 no 2219 0.355576407740751 688 875334 SGTC_168 3970-0862 530.542 µM -0.370716599363983 0.347384441307237 no 2220 0.355424312722641 698 3135186 SGTC_2508 celastrol 40.54 µM -0.370947223990507 0.347296210903034 no 2221 0.355338420377886 670 122724 Celastrol is a natural product and antioxidant. SGTC_1098 clofazimine 15.1 µM -0.372032461065481 0.346881141302647 no 2222 0.354934340402466 691 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_181 1447-1644 8.07 µM -0.372540998464004 0.346686704654446 no 2223 0.354745046373981 736 534600 SGTC_1627 st003713 25.6 µM -0.373179352976409 0.346442690260167 no 2224 0.354507480989668 690 16195070 YER133W GLC7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.373514737298068 0.346314513350236 no 2225 0.354382689463068 691 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_575 k072-0246 11.9 µM -0.374754486385277 0.345840859911962 no 2226 0.353921533017415 716 6796779 SGTC_1617 st002906 78 µM -0.375624157782481 0.345508740703427 no 2227 0.353598164251558 717 5150859 SGTC_27 0485-0001 32.618 µM -0.375632723319222 0.345505470197542 no 2228 0.353594979864256 703 2054479 SGTC_2536 dehydroabietamide 32.04 µM -0.376310031637353 0.345246895865485 no 2229 0.353343211166618 709 3983547 SGTC_622 1348-1566 26.3 µM -0.376383418334952 0.345218883540808 no 2230 0.353315935752205 710 7340407 SGTC_96 0929-0093 37.281 µM -0.3784992917894 0.344411601923088 no 2231 0.352529859889169 700 6991579 SGTC_843 0310-0051 143 µM -0.379284035339805 0.344112373965465 no 2232 0.352238476766065 743 2065037 SGTC_2805 7950783 58.44 µM -0.381621339117189 0.343221723189001 no 2233 0.351371126874973 691 1178958 YDL195W SEC31 SGTC_1879 gemcitabine 100 µM -0.381741561184964 0.343175934968932 no 2234 0.351326534552651 707 60750 A nucleoside analog which inhibits DNA replication. SGTC_2956 9076196 2.52 µM -0.381765267168879 0.343166906492209 no 2235 0.351317741858783 732 16423868 SGTC_497 capsazepine 133 µM -0.382968302219302 0.342708845563991 no 2236 0.350871633407093 684 2733484 A calcium channel blocker. SGTC_1949 st076024 69.1 µM -0.385756694302838 0.341648042685746 no 2237 0.34983843520592 712 2921930 SGTC_208 k072-0098 12.366 µM -0.386016322869502 0.34154933426114 no 2238 0.349742290031233 735 5948901 SGTC_348 k064-0012 10.7 µM -0.386379813359975 0.341411156681789 no 2239 0.349607699088618 708 5066323 SGTC_2656 pseudo-anisatin 100 µM -0.387519772388837 0.340977949635122 no 2240 0.349185724983109 716 6708809 A neurotoxin. SGTC_1571 st070080 73.4 µM -0.387868737114499 0.340845377986813 no 2241 0.349056587333152 715 4315245 SGTC_3184 9108758 49.47 µM -0.388094954573114 0.340759448505377 no 2242 0.348972882790291 721 902885 SGTC_1818 st052136 56.3 µM -0.389675660303374 0.340159242777903 no 2243 0.348388198411456 707 674169 SGTC_2699 st077704 54.6 µM -0.3900467062953 0.34001841246014 no 2244 0.348251005010906 714 645852 SGTC_742 0kpi-0133 140 µM -0.391382762505947 0.339511498002749 no 2245 0.347757165874682 723 2728852 SGTC_1559 coumarin 343 70.1 µM -0.392059458469218 0.339254862751926 no 2246 0.347507140899313 739 108770 A hepatotoxic, DNA x-linker. SGTC_1050 3232-1156 69.3 µM -0.39427600466121 0.33841476570897 no 2247 0.346688638477882 734 700529 SGTC_568 1193-0097 7.48 µM -0.394633761613822 0.338279246833729 no 2248 0.346556596750733 713 3646150 SGTC_2976 9009005 19.48 µM -0.396546652753695 0.337554996580222 no 2249 0.345850899307801 727 2993148 SGTC_2857 9024691 58.44 µM -0.397472319784115 0.337204740396375 no 2250 0.345509597291969 768 16478292 SGTC_792 4534-1957 155 µM -0.398025064838385 0.336995658595248 no 2251 0.3453058549192 702 1717904 SGTC_926 2268-1401 59.4 µM -0.399518798991081 0.336430889520855 no 2252 0.344755487401914 737 2931578 SGTC_1182 1222-0449 220 µM -0.399993816351191 0.336251366449823 no 2253 0.344580535645707 710 658318 SGTC_403 arphamenine a 50 µM -0.401640610744535 0.335629283563071 no 2254 0.343974268915597 749 5487158 An arginine aminopeptidase inhibitor. SGTC_1398 3558-0053 112 µM -0.402089479902785 0.335459799533676 no 2255 0.343809087370776 698 4532369 SGTC_730 1436-0052 41.2 µM -0.403905200900265 0.33477456144882 no 2256 0.343141215840456 682 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2417 cerulenin 830 nM -0.404731345712032 0.334462963082912 no 2257 0.342837499284421 744 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_78 0336-0123 156.75 µM -0.405104749817515 0.334322163051656 no 2258 0.342700257615963 694 6765896 SGTC_3172 9105863 49.47 µM -0.40643290826024 0.333821541398522 no 2259 0.342212272031058 723 2348785 SGTC_2158 5657123 3.6195 µM -0.406442645697444 0.333817872165124 no 2260 0.342208695320298 771 2858827 SGTC_449 xestospongin c 11.1929 µM -0.406893831817607 0.333647874925388 no 2261 0.342042983232914 737 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2962 9082311 13.18 µM -0.407800322101781 0.333306432104968 no 2262 0.341710138561195 710 16459453 SGTC_2944 9067346 25.62 µM -0.408091554455775 0.333196764475324 no 2263 0.341603230103206 741 6473075 SGTC_1235 benzylparaben 21.5 µM -0.408456939568515 0.333059193753692 no 2264 0.341469118886313 740 7180 SGTC_1010 4112-3296 15.2 µM -0.409005554238342 0.33285267767426 no 2265 0.34126779254927 724 704384 SGTC_852 0418-0143 439 µM -0.409416481780026 0.332698024629872 no 2266 0.34111702314679 729 5369229 SGTC_956 1185-0240 191 µM -0.410748027844557 0.332197091434374 no 2267 0.340628652969599 729 1416193 SGTC_1557 sumaresinolic acid 42.3 µM -0.412482717744416 0.33154494342115 no 2268 0.339992822672399 727 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1902 st060212 70.5 µM -0.412701539182575 0.331462714801104 no 2269 0.339912648503513 703 688944 SGTC_308 4092-1169 104 µM -0.412790369510339 0.331429336498991 no 2270 0.339880103951699 727 2268590 YDL196W YDL196W SGTC_389 tpck 16.7 µM -0.412841540425787 0.331410109458723 no 2271 0.339861357129162 716 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2982 9019404 25.97 µM -0.412987433298085 0.331355293880809 no 2272 0.33980791042998 697 22333232 SGTC_2785 7756463 72.73 µM -0.414384812696395 0.330830446879697 no 2273 0.33929615481412 720 2201551 SGTC_1620 st003704 16.5 µM -0.415538260824882 0.330397469277647 no 2274 0.338873956142023 729 2834414 SGTC_785 1270-0111 65.3 µM -0.416028404735235 0.330213549327682 no 2275 0.338694609117915 702 6741994 SGTC_582 0987-0078 156 µM -0.416057641836486 0.33020257979216 no 2276 0.33868391221704 745 1625765 SGTC_1019 4262-0212 3.4 µM -0.416356043931503 0.330090629968825 no 2277 0.338574744074601 738 4677213 SGTC_672 1441-0018 53.7 µM -0.418336659907233 0.329347959461084 no 2278 0.33785049488533 719 251141 SGTC_2358 9037157 4 µM -0.418647182920858 0.329231583747146 no 2279 0.337737000685146 729 2388925 SGTC_1940 st075990 51.1 µM -0.420165208157344 0.328662906827768 no 2280 0.337182384568955 741 1084979 SGTC_918 glabranin 770.725 nM -0.421211133866148 0.328271316707628 no 2281 0.336800457459032 729 124049 Also referred to as licorice root. SGTC_2090 5301565 104.445 µM -0.422710918698452 0.327710132879338 no 2282 0.336253094149492 732 2056344 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.423736530185727 0.327326597270042 no 2283 0.335878985389597 703 3256 An antibiotic and ribosome inhibitor. SGTC_587 k089-0003 57 µM -0.425273356890656 0.326752229813889 no 2284 0.335318706794734 715 9659696 SGTC_3004 9076122 71.4286 µM -0.425419453135751 0.326697649724753 no 2285 0.335265463743573 749 44782551 SGTC_3021 9087658 49.47 µM -0.427148804527714 0.326051863463108 no 2286 0.334635473719262 719 25237042 SGTC_832 4083-0019 164 µM -0.427600848649254 0.325883143919111 no 2287 0.334470873992582 738 1990758 SGTC_1282 0886-0010 32.4 µM -0.427737896092407 0.325831999797684 no 2288 0.334420978129937 726 2836211 YNL267W PIK1 SGTC_2051 5263410 176 µM -0.431250836939477 0.32452214213018 no 2289 0.333142996634085 741 227584 SGTC_687 k029-0044 34.9 µM -0.431285248232836 0.324509322010326 no 2290 0.333130487611255 748 5829338 SGTC_3223 9129970 49.47 µM -0.43203206661485 0.324231141897865 no 2291 0.332859053649402 712 17248386 SGTC_924 2046-0044 21.3 µM -0.432346811796009 0.324113932791927 no 2292 0.332744684545635 728 3623589 SGTC_1080 nisoldipine 24.4 µM -0.43269770359192 0.323983283465579 no 2293 0.332617199175611 749 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1793 st048256 72.231 µM -0.434789679640609 0.323204817746856 no 2294 0.331857548340776 751 672022 SGTC_1853 st056710 91.2 µM -0.435590415634039 0.322907052545847 no 2295 0.331566962928023 743 269167 SGTC_292 k038-0015 474 µM -0.435878571380345 0.32279992544245 no 2296 0.331462416599394 760 46368540 SGTC_8 0354-0001 70 µM -0.436049473506529 0.322736396435662 no 2297 0.331400417479944 736 4993152 SGTC_1338 1486-1223 76 µM -0.436969411528411 0.322394519158513 no 2298 0.331066765827553 731 3444526 SGTC_2721 ifenprodil 61.44 µM -0.437025417512154 0.322373710457675 no 2299 0.331046457386113 711 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_815 1582-0027 36.9 µM -0.437517715306877 0.32219082399922 no 2300 0.330867965694518 719 3128206 SGTC_1957 st077035 62.4 µM -0.439334191792644 0.32151638367255 no 2301 0.330209701340717 751 705593 SGTC_2734 clemastine 41.6 µM -0.439734112311538 0.3213679759041 no 2302 0.330064846498823 747 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1649 st011737 51.3 µM -0.439808603076439 0.321340336040416 no 2303 0.330037868081182 733 1761035 SGTC_2222 6885208 172.143 µM -0.440632586762234 0.321034662200894 no 2304 0.329739503821249 712 609514 SGTC_1628 st004252 77.7 µM -0.442667940533134 0.320280125456098 no 2305 0.329002967333972 699 692968 SGTC_2396 5342950 42.78 µM -0.442676660186249 0.320276894542511 no 2306 0.328999813365347 741 1886677 SGTC_2298 7976326 193.81 µM -0.442839176095301 0.320216679633919 no 2307 0.328941032282803 731 2235818 SGTC_2007 4011539 71.82 µM -0.443506775211037 0.319969372488504 no 2308 0.3286996098636 742 45595301 SGTC_556 4058-0063 51.5 µM -0.443785654872267 0.319866087263039 no 2309 0.328598780375942 746 6615692 SGTC_1943 st076331 65.2 µM -0.444080632343347 0.319756855286017 no 2310 0.328492144273112 746 24208415 SGTC_974 1326-0144 138 µM -0.44462693897349 0.319554595856533 no 2311 0.328294688085437 747 5411856 SGTC_2418 pentamidine 31.67 µM -0.445857556403773 0.319099180295945 no 2312 0.32785007146448 746 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2555 cholic acid 100 µM -0.44631176641689 0.318931159352125 no 2313 0.327686028992075 743 6708657 Influences liver metabolism. SGTC_777 1315-0167 517 µM -0.446731140854987 0.318776057782463 no 2314 0.327534597257805 715 4221767 SGTC_216 k038-0035 28.382 µM -0.447352351684848 0.318546367311272 no 2315 0.327310336646844 728 4444231 YPR107C YTH1 SGTC_108 0509-0257 621.132 µM -0.447643477621629 0.318438748528148 no 2316 0.32720525998273 725 536624 SGTC_159 3970-0959 50 µM -0.44889792380515 0.317975200215808 no 2317 0.326752646931014 725 6615653 SGTC_115 0527-0192 112.043 µM -0.44983189433108 0.31763026050075 no 2318 0.326415829206252 761 4233931 SGTC_395 anisomycin 6.25 µM -0.45169666785922 0.316942024551373 no 2319 0.325743759526765 750 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.452263036921126 0.316733118705784 no 2320 0.325539750451138 734 16725076 SGTC_3268 9137683 49.47 µM -0.45441684152256 0.315939219592844 no 2321 0.324764416452651 769 1953228 SGTC_817 1391-0715 46 µM -0.455085905389374 0.315692773049786 no 2322 0.324523718805953 766 1353946 SGTC_2362 9071156 126 µM -0.455734328933272 0.315454007444912 no 2323 0.324290516494698 754 653133 SGTC_1388 3346-4487 254 µM -0.456189016618955 0.315286626121587 no 2324 0.324127031417596 759 3345614 SGTC_2973 9094665 17.96 µM -0.456517985881878 0.315165548363768 no 2325 0.324008770124485 764 25237061 YIL048W NEO1 SGTC_312 4092-0653 6.84 µM -0.457245137434607 0.314897989318549 no 2326 0.323747429145478 754 1148278 SGTC_422 cantharidin 155 µM -0.457567328846416 0.314779468420683 no 2327 0.323631660119836 737 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.457916321203073 0.314651110086148 no 2328 0.323506280299253 750 2346 DNA damaging agent; causes G2/M arrest. SGTC_1655 st012546 55.1 µM -0.458493217487691 0.31443897848808 no 2329 0.323299067112393 740 720985 YLR208W SEC13 SGTC_1462 k081-0014 26.5 µM -0.459387767040081 0.314110163169197 no 2330 0.322977865644877 749 3270634 SGTC_2755 lomerizine 42.69 µM -0.461750951749164 0.31324222225895 no 2331 0.322129963988866 734 3949 A calcium channel blocker. SGTC_569 4130-2812 160 µM -0.464883324097655 0.312093370429649 no 2332 0.321007506557494 771 743552 SGTC_2455 5377712 9.75 µM -0.465368244447495 0.311915680359483 no 2333 0.320833885496868 713 2243908 SGTC_2930 9013230 14.89 µM -0.46543844751801 0.311889959371782 no 2334 0.320808753209244 744 2995857 SGTC_2189 6047310 154.431 µM -0.465616366339875 0.311824777616148 no 2335 0.320745062992226 745 711535 SGTC_144 4161-2749 112.381 µM -0.466018973521245 0.311677301531106 no 2336 0.32060095978478 733 797501 YMR168C CEP3 SGTC_984 1492-0255 2.91 µM -0.466227546218744 0.311600912668778 no 2337 0.320526317014714 753 1585198 SGTC_2502 avocadyne acetate 18.59 µM -0.466832270294701 0.31137948089017 no 2338 0.320309942957041 716 3952079 SGTC_289 k017-0060 526 µM -0.466925652185034 0.311345293327883 no 2339 0.320276535774698 754 5512909 SGTC_230 MPP+ 141.667 µM -0.467919033517676 0.31098171236979 no 2340 0.319921245822634 760 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_197 4544-0043 41.561 µM -0.468007846526678 0.310949215481407 no 2341 0.319889489250097 750 896523 SGTC_1164 k060-0068 93.7 µM -0.469040669348447 0.310571411497044 no 2342 0.31952028320417 733 5963676 SGTC_3210 9128157 49.47 µM -0.469744655369076 0.310314009611351 no 2343 0.31926872982409 748 17590849 SGTC_2168 5727979 200 µM -0.470027341221022 0.310210675917618 no 2344 0.31916774186874 731 695210 SGTC_1898 st060199 18.6 µM -0.471266225683905 0.309757987798893 no 2345 0.318725315590992 727 688866 SGTC_3059 1327-0034 3 µM -0.471438654856951 0.309695005061268 no 2346 0.318663758720838 733 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2184 6075246 200 µM -0.471490445453709 0.309676088741078 no 2347 0.318645270558407 754 2267320 SGTC_1903 st060211 78.3 µM -0.471732436253449 0.309587709194689 no 2348 0.318558890875454 740 688960 SGTC_138 0850-0259 40.9225 µM -0.472178304037162 0.309424898809394 no 2349 0.318399762227189 741 6813004 SGTC_1356 1502-0781 85.8 µM -0.473335686812724 0.309002450519966 no 2350 0.317986852767863 741 567702 SGTC_597 k018-0003 82.8 µM -0.473417933025124 0.308972440000713 no 2351 0.317957519097857 776 6786234 SGTC_806 3966-4455 5.86 µM -0.474184935720348 0.308692632608756 no 2352 0.317684017390758 765 714982 SGTC_1730 st033808 45.1 µM -0.474198828534464 0.308687565446368 no 2353 0.317679064337369 767 1045166 SGTC_3256 9138902 49.47 µM -0.474228518692034 0.308676736599735 no 2354 0.317668479338915 771 17228773 SGTC_1651 st011928 86.1 µM -0.474646545909413 0.308524287824921 no 2355 0.317519462022182 746 720198 SGTC_174 3553-0389 74.3 µM -0.477013407590589 0.307661748980682 no 2356 0.316676287152105 727 738071 SGTC_2800 7887935 81.82 µM -0.477331332803264 0.307545970530436 no 2357 0.316563101330967 771 2961002 SGTC_233 rapamycin 362 pM -0.477754893430028 0.307391752737406 no 2358 0.316412334510355 758 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1232 0279-0259 161 µM -0.480204455711694 0.306500539229279 no 2359 0.315541009427351 744 1560000 SGTC_58 0957-0393 9 µM -0.480472474438826 0.306403096442345 no 2360 0.315445735537046 754 6997992 SGTC_177 1327-0068 8.361 µM -0.481131585890964 0.306163523448381 no 2361 0.315211490250348 741 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_982 1491-0518 27.5 µM -0.481779817529416 0.305927985860382 no 2362 0.31498118404382 741 3091256 SGTC_132 0417-1715 25.805 µM -0.482216549807002 0.305769342652107 no 2363 0.31482606067838 775 6769098 SGTC_912 3474-0017 2.18 µM -0.483355723744635 0.305355708736122 no 2364 0.314421590155441 784 3360550 SGTC_950 1165-0508 94.1 µM -0.485022344249773 0.30475100664476 no 2365 0.313830247834294 733 6148369 SGTC_2889 9059656 51.95 µM -0.485717462614021 0.304498953361455 no 2366 0.313583750391551 749 3949838 SGTC_3272 9137413 49.47 µM -0.486404526649409 0.304249911815997 no 2367 0.313340190882121 788 17614870 SGTC_998 3996-0085 177 µM -0.487504494461011 0.303851393177371 no 2368 0.312950429279519 749 715391 SGTC_653 0203-0016 55.2 µM -0.488591251598109 0.303457889598596 no 2369 0.312565553934246 755 295302 SGTC_2979 9012552 45.46 µM -0.488646628493088 0.303437844291578 no 2370 0.312545947658992 763 17100905 SGTC_1851 st056236 18.9 µM -0.488735007338517 0.303405854176776 no 2371 0.312514658091197 760 5393171 SGTC_3145 9085516 49.47 µM -0.489032281899365 0.303298262028917 no 2372 0.312409421189639 739 25236195 SGTC_871 0574-0004 149 µM -0.491556767317866 0.302385266945195 no 2373 0.31151635613216 761 9551173 SGTC_200 k038-0079 37.545 µM -0.495190200353159 0.301073382944468 no 2374 0.310232933687731 746 3436683 SGTC_3074 9116018 49.47 µM -0.495957357468994 0.300796722202443 no 2375 0.309962248523978 793 17027303 SGTC_1575 cyproterone acetate 48 µM -0.496376596926543 0.300645579882874 no 2376 0.309814366786824 780 9880 An androgen receptor antagonist and liver toxin. SGTC_3264 9137442 49.47 µM -0.496700011916928 0.300529007197214 no 2377 0.309700307015807 763 17015726 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.498092501844419 0.300027327191315 no 2378 0.309209422633482 747 641818 YHR062C RPP1 SGTC_317 4495-0002 170 µM -0.499120715424663 0.299657130386589 no 2379 0.308847172356459 757 15991618 SGTC_1111 tnp00062 510.699 nM -0.499625746364735 0.299475375457664 no 2380 0.308669312780148 739 676306 SGTC_2154 5570129 200 µM -0.499700881854425 0.299448339315152 no 2381 0.30864285572744 785 673366 SGTC_2991 9074669 71.4286 µM -0.500710806524717 0.299085043704848 no 2382 0.308287332880288 789 17333109 SGTC_2592 piperlongumine 83.33 µM -0.501101182683896 0.298944669104558 no 2383 0.308149957272183 762 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2391 6285546 200 µM -0.502271685204952 0.298523949888007 no 2384 0.30773821186038 743 846083 SGTC_1512 0259-0544 12.2 µM -0.503002697453282 0.298261335437023 no 2385 0.307481187827856 727 18476 SGTC_2704 st078022 71.1 µM -0.503169786623983 0.298201323814338 no 2386 0.307422452510252 785 54697681 SGTC_1473 k844-0725 134 µM -0.503398955469643 0.298119024646462 no 2387 0.307341902927046 750 54682906 SGTC_2731 amoxapine 43.43 µM -0.5035582741532 0.298061816182781 no 2388 0.307285910155459 778 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2603 homopterocarpin 100 µM -0.504643368592243 0.297672311487417 no 2389 0.306904671750618 755 101795 A weak amylase inhibitor. SGTC_1448 4255-0083 152 µM -0.504918155011816 0.297573711226577 no 2390 0.306808161059063 796 5399660 SGTC_254 nsc-64875 3.808 µM -0.504973366227966 0.297553901855964 no 2391 0.306788771349704 766 56993 SGTC_3306 9127676 59.7925 µM -0.505729911949211 0.29728251958424 no 2392 0.306523133403075 725 41905287 SGTC_2404 5161160 200 µM -0.506253761735307 0.297094674507679 no 2393 0.306339259067716 771 2831543 SGTC_2678 equilin 100 µM -0.506383640304766 0.297048110299057 no 2394 0.306293678472356 740 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_620 0109-0052 432 µM -0.507904039172957 0.296503263625266 no 2395 0.305760320961782 777 493037 SGTC_1724 st037281 8.293 µM -0.508173320339782 0.296406812395819 no 2396 0.305665899737814 740 574124 YDL195W SEC31 SGTC_787 4152-0075 138 µM -0.508792439992775 0.296185110450732 no 2397 0.30544885953784 736 9566539 SGTC_3336 9143619 71.43 µM -0.51163914380028 0.295166708343007 no 2398 0.304451792322731 771 45595730 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.513192251428181 0.294611768083022 no 2399 0.303908422808749 782 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1922 5578187 25 µM -0.514454841006645 0.29416098771729 no 2400 0.303467012781071 731 1350412 SGTC_1698 5-fluorocytosine 1.055 µM -0.514979114139556 0.293973900997726 no 2401 0.303283807465049 768 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.516415434240729 0.293461632617325 no 2402 0.302782144153354 779 4213774 SGTC_519 k048-0011 62.8 µM -0.516790092571664 0.293328077494056 no 2403 0.302651348429261 751 6836379 SGTC_2131 toluylene red 5.2905 µM -0.517955901804218 0.292912679695855 no 2404 0.302244518692265 735 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_746 1095-0025 46.6 µM -0.5223426800061 0.2913520473489 no 2405 0.300715878919818 791 6749286 SGTC_3137 9097352 49.47 µM -0.523185671153848 0.291052591359812 no 2406 0.300422525905536 820 44120435 SGTC_666 0272-0154 136 µM -0.523816034454147 0.290828761216392 no 2407 0.300203249906996 762 6870312 SGTC_3331 9141060 1.957 µM -0.524318467369763 0.290650414395677 no 2408 0.300028527171798 762 4906567 YPR165W RHO1 SGTC_981 1488-1094 54.9 µM -0.524596361865489 0.290551793155954 no 2409 0.299931908191583 763 3449522 SGTC_411 enrofloxacin 100 µM -0.524808210285684 0.290476621352835 no 2410 0.29985826171949 769 71188 A bacterial gyrase inhibitor. SGTC_1204 4049-0315 18.3 µM -0.527122380524549 0.289656060002547 no 2411 0.299054302911894 771 588402 SGTC_896 0964-0007 44.5 µM -0.527157347184978 0.289643669829204 no 2412 0.299042162760005 744 6756758 SGTC_1606 st000094 49.2 µM -0.527475944347944 0.289530788780601 no 2413 0.298931558618516 764 1242210 SGTC_2443 5493264 126.67 µM -0.528649836610457 0.289115049500071 no 2414 0.298524190826269 784 5340055 SGTC_1307 1187-1599 12.2 µM -0.528773868084237 0.28907113959242 no 2415 0.298481163788254 773 1538471 SGTC_868 0527-0199 213 µM -0.530078855026873 0.288609335334547 no 2416 0.298028629473654 773 2849450 SGTC_2231 micatex 6.853 µM -0.530837669157232 0.28834096871047 no 2417 0.297765637023399 773 20737 An antifungal of unknown mechanism. SGTC_735 3076-0345 636 µM -0.531141118543442 0.288233681977679 no 2418 0.297660496116033 763 2888990 SGTC_668 1682-0499 62.6 µM -0.531878924397448 0.287972903939748 no 2419 0.297404927553898 785 682214 SGTC_1596 piperlongumine 63 µM -0.532401268699607 0.287788348319562 no 2420 0.297224053334254 764 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1947 st076332 61.6 µM -0.533105018180728 0.287539786684302 no 2421 0.296980442761199 780 24208416 SGTC_576 1073-0113 22.7 µM -0.534883722628963 0.286912007926177 no 2422 0.296365132322413 803 5439563 SGTC_1368 1852-0141 284 µM -0.535431162670793 0.28671892434688 no 2423 0.296175873093524 782 2838987 SGTC_3312 9133330 71.43 µM -0.535679930521383 0.286631203617839 no 2424 0.296089888191082 790 17617324 SGTC_1694 st024011 44.9 µM -0.536386647820525 0.286382069832557 no 2425 0.295845678722556 790 2787533 SGTC_2151 5563267 85.4165 µM -0.537177179856896 0.286103511311038 no 2426 0.295572616355652 786 5310824 SGTC_3171 9103192 49.47 µM -0.53740733195611 0.28602243718101 no 2427 0.295493139935771 781 13018434 SGTC_1735 st034310 56.75 µM -0.538911348712537 0.285492896307299 no 2428 0.294974013063916 772 871153 SGTC_636 0kpi-0074 126 µM -0.540501225188481 0.284933633539768 no 2429 0.294425708142481 774 616434 SGTC_227 fluconazole 33.516 µM -0.540548174091616 0.28491712650904 no 2430 0.294409523904018 790 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1573 oleylamine 1.06 µM -0.541113382498234 0.284718437494467 no 2431 0.294214717353719 792 5356789 An amine of the fatty acid oleic acid. SGTC_2307 7538926 6.34 µM -0.543144978191105 0.284004812587622 no 2432 0.293514993235778 777 96582 SGTC_901 1112-0062 60.1 µM -0.543709568195239 0.283806644933928 no 2433 0.293320673549906 767 1908457 SGTC_3094 9117742 49.47 µM -0.545385020877613 0.283218961283297 no 2434 0.292744370199312 815 17149698 SGTC_457 grayanotoxin iii 135 µM -0.545763534635437 0.2830862742584 no 2435 0.292614246147935 790 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_187 1488-2104 32.728 µM -0.545955018906182 0.283019161304794 no 2436 0.292548428634874 766 2852859 SGTC_1139 k015-0024 46.9 µM -0.546794183127841 0.282725134362852 no 2437 0.292260069913268 791 2766652 SGTC_1026 k007-1105 30.6 µM -0.547733899572993 0.282396050168351 no 2438 0.29193731583966 782 7066794 SGTC_1801 st050089 28.441 µM -0.548665565965387 0.282069967060037 no 2439 0.291617490584016 772 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1074 carmofur 3.8 µM -0.549077483551399 0.281925853786451 no 2440 0.291476138365121 793 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_351 caspofungin 25 nM -0.551029041863767 0.281243565152266 no 2441 0.290806883114983 769 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.551644149443034 0.281028681390311 no 2442 0.290596090957346 789 442882 SGTC_2684 capsaicin 100 µM -0.552469823578283 0.280740362366126 no 2443 0.290313251860048 792 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_371 0195-0006 7.36 µM -0.552510869006454 0.280726033353343 no 2444 0.290299194893215 768 3928593 SGTC_1269 0831-0796 3.05 µM -0.552795797478732 0.28062657420173 no 2445 0.290201623262196 795 927758 SGTC_412 gemfibrozil 100 µM -0.553480731804836 0.280387555945427 no 2446 0.289967135489926 768 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_202 3594-0513 34.79 µM -0.553831139267171 0.280265314054186 no 2447 0.28984720759684 781 708429 SGTC_721 1187-1332 279 µM -0.553872723103274 0.280250808979903 no 2448 0.289832976962021 787 25730 SGTC_393 acivicin 6.25 µM -0.554058981900438 0.280185843542137 no 2449 0.289769240329751 783 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_278 4092-0821 23.9 µM -0.554408845836732 0.280063833792906 no 2450 0.289649536791305 790 877900 SGTC_2855 9016525 58.44 µM -0.555338044764763 0.279739914818268 no 2451 0.289331730509961 773 43811474 SGTC_98 0074-0023 107.663 µM -0.555527040040957 0.27967405327222 no 2452 0.2892671100659 793 3563821 SGTC_585 0kpi-0023 191 µM -0.557403769946008 0.279020454455369 no 2453 0.288625795152337 771 64601 SGTC_2275 7947463 200 µM -0.558277679199472 0.278716356402072 no 2454 0.288327392174043 789 1225414 SGTC_2895 9054447 58.44 µM -0.558590358725496 0.278607591135594 no 2455 0.288220660712494 776 2697450 SGTC_1260 0700-1617 7.75 µM -0.559976265548038 0.278125753808887 no 2456 0.287747813437707 765 2853078 SGTC_1194 1488-0194 225 µM -0.560424341035618 0.277970058687996 no 2457 0.287595016323812 781 1391452 SGTC_1896 st058441 89 µM -0.562345111393927 0.277303120984909 no 2458 0.286940454154098 754 688759 SGTC_384 k007-0144 5.16 µM -0.563938127635545 0.276750581715353 no 2459 0.286398120365368 783 6824886 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.56428218985869 0.276631314257241 no 2460 0.286281050154221 799 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3026 9090633 49.47 µM -0.565284043647664 0.276284170161416 no 2461 0.285940290021848 779 25236842 SGTC_502 l-744,832 89.3 µM -0.566170683692932 0.275977126218901 no 2462 0.285638878411138 803 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_820 1582-0060 59.9 µM -0.567098186162589 0.275656111049115 no 2463 0.285323737584309 783 3848840 SGTC_218 alverine citrate 93.75 µM -0.567328359509177 0.275576474865271 no 2464 0.285245556422362 787 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1792 st045773 43.6 µM -0.567333256213806 0.275574780809094 no 2465 0.285243893308279 749 2919270 SGTC_3282 9108498 15.4605 µM -0.568781140679086 0.275074097739451 no 2466 0.284752337392903 792 16459645 SGTC_853 0419-0306 21 µM -0.56881036293493 0.275063997204597 no 2467 0.284742420617894 783 762713 SGTC_2964 9083345 53.42 µM -0.571435722527458 0.27415730022995 no 2468 0.283852159968531 777 17741579 SGTC_2826 7992541 19.48 µM -0.576445504723597 0.272431223498651 no 2469 0.282157047160771 836 2985066 SGTC_2834 9001755 58.44 µM -0.578174722512496 0.271836692092922 no 2470 0.281573081407071 785 2989575 SGTC_1867 st057372 64 µM -0.578303589045531 0.271792411678095 no 2471 0.281529585865212 761 688837 SGTC_3062 9077494 49.47 µM -0.578402849246914 0.271758306876773 no 2472 0.281496085379337 749 16459633 SGTC_656 4090-1979 187 µM -0.579045471625371 0.271537559870803 no 2473 0.281279245781583 786 22330961 SGTC_1732 st034308 51.822 µM -0.580759463944019 0.270949224007922 no 2474 0.280701289304257 776 830119 SGTC_919 tnp00227 403.569 nM -0.583896123784139 0.269874200505038 no 2475 0.27964510061253 806 1269246 A methoxyflavone. YNL221C POP1 SGTC_2630 antimycin a 100 µM -0.583913434703344 0.26986827348521 no 2476 0.27963927696644 802 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2514 salinomycin 42.74 µM -0.584721846487212 0.269591557047698 no 2477 0.279367381015852 794 23682228 A polyether potassium ionophore. SGTC_2706 st078239 82.5 µM -0.58591401497913 0.269183741654219 no 2478 0.27896664933521 796 15434492 SGTC_3092 9117248 49.47 µM -0.586510200276 0.268979915537129 no 2479 0.278766354459544 801 17141857 SGTC_425 3825-7017 13.1 µM -0.590712440781669 0.267545438614209 no 2480 0.277356555405474 794 3397440 SGTC_1444 4112-3581 28 µM -0.590768720395634 0.267526253210665 no 2481 0.277337697982597 788 2877249 SGTC_2903 5923464 63.88 µM -0.591150277464635 0.267396200850582 no 2482 0.277209867461994 801 2876576 SGTC_2918 7977171 22.06 µM -0.592195417767299 0.267040131912093 no 2483 0.276859868750084 807 2236483 SGTC_1707 st032323 6.317 µM -0.592356200231349 0.266985376178219 no 2484 0.276806044804922 790 3132057 YMR211W DML1 SGTC_886 0866-0150 153 µM -0.592455120137848 0.266951691043098 no 2485 0.276772932673255 785 271463 SGTC_1303 1160-0052 261 µM -0.593028307972451 0.266756546008518 no 2486 0.276581103824796 789 3562476 SGTC_2281 7943571 200 µM -0.594184340440644 0.266363187689611 no 2487 0.276194412667147 805 1244024 SGTC_1852 st056254 31.4 µM -0.595067740485743 0.266062794827463 no 2488 0.275899095615076 791 442583 SGTC_2087 5276107 200 µM -0.595093703611606 0.266053968877837 no 2489 0.275890418594403 804 144405 SGTC_3243 9134147 49.47 µM -0.59520064560277 0.266017616396952 no 2490 0.275854679401195 812 24282180 SGTC_2475 5812728 15.03 µM -0.595511547985818 0.265911946543138 no 2491 0.275750791130102 801 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3278 9139605 49.47 µM -0.595987932036905 0.265750073865189 no 2492 0.275591644346565 809 7958859 SGTC_3100 9120536 49.47 µM -0.597256089302844 0.26531940463434 no 2493 0.275168208225954 807 16421196 SGTC_2565 isoliquiritigenin 100 µM -0.598010018734759 0.265063536423088 no 2494 0.274916624059872 770 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1478 0453-0656 35.7 µM -0.598358037967899 0.264945468121783 no 2495 0.274800529254667 820 5258496 SGTC_532 1548-0774 215 µM -0.599034699362005 0.264715981868941 no 2496 0.274574872789988 830 5932993 SGTC_2439 5492030 7.2 µM -0.599101956708674 0.264693177407673 no 2497 0.274552448465317 789 5722370 SGTC_3078 9116413 49.47 µM -0.599649179074047 0.264507671825442 no 2498 0.274370032215793 798 17177322 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.600271182555256 0.264296896188917 no 2499 0.274162760403095 820 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_681 1642-0006 26.6 µM -0.602059544252415 0.263691358555895 no 2500 0.273567251278433 820 4446530 SGTC_1915 st067105 30.6 µM -0.604973332088658 0.262706270742482 no 2501 0.272598358095005 811 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1248 0469-0687 58.6 µM -0.606033069679922 0.262348464132469 no 2502 0.272246396883455 797 4017482 SGTC_2108 5365811 200 µM -0.607331153569318 0.261910523336014 no 2503 0.271815583782725 780 780283 SGTC_2394 5221648 200 µM -0.608664055710353 0.261461226159431 no 2504 0.271373568356948 799 788586 SGTC_1759 st043059 70 µM -0.609537373927438 0.261167061148091 no 2505 0.271084153946938 819 669426 SGTC_1919 st067113 52.3 µM -0.610482379717233 0.260848940892854 no 2506 0.270771156049595 809 1268243 SGTC_1466 k213-0079 57.5 µM -0.611686654178028 0.260443831266856 no 2507 0.27037254670826 831 3657981 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.611697192186848 0.260440287783961 no 2508 0.27036905997046 796 4330530 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.611991238730048 0.260341422486809 no 2509 0.270271777106559 809 2374 Ca(2+)-ATPase inhibitor. SGTC_1666 st014829 29 µM -0.612250553924442 0.260254250724558 no 2510 0.270185999347218 801 3858230 SGTC_1477 0139-0234 16 µM -0.614576105399286 0.259473162874385 no 2511 0.269417349252091 808 620880 SGTC_2402 5553605 200 µM -0.61670443878435 0.25875937764242 no 2512 0.268714846456012 806 6758546 SGTC_3098 9119039 49.47 µM -0.616812705637912 0.258723095061072 no 2513 0.268679135235332 808 17161528 SGTC_68 0986-0284 82.829 µM -0.61777412435949 0.258401018258392 no 2514 0.268362121249777 789 423278 YIL048W NEO1 SGTC_1467 k284-1082 293 µM -0.618098479475354 0.258292405659245 no 2515 0.268255212273901 813 3334705 SGTC_1967 st070177 51.4 µM -0.618133390002323 0.258280717033431 no 2516 0.268243706876915 813 5729214 SGTC_2022 5136654 200 µM -0.620244443975229 0.257574410856608 no 2517 0.267548432531125 819 1713771 SGTC_913 3487-1245 167 µM -0.621378420809119 0.257195424952878 no 2518 0.26717533342964 781 4016153 SGTC_1843 st055809 45.5 µM -0.622818906152647 0.256714419356553 no 2519 0.266701766421089 809 16413835 SGTC_1670 st016595 4.04 µM -0.623910390767297 0.256350263907827 no 2520 0.266343217979369 830 597879 SGTC_315 k915-0449 187 µM -0.625681804808914 0.255759834988324 no 2521 0.265761835004111 804 20970215 YNL149C PGA2 SGTC_2349 9023730 187.07 µM -0.62615284994127 0.25560295080354 no 2522 0.265607345042219 811 4126287 SGTC_528 3492-0019 172 µM -0.627420572374688 0.25518097863498 no 2523 0.265191793005419 813 2869262 SGTC_1654 st012436 41.8 µM -0.6275581543466 0.25513520523085 no 2524 0.265146714302559 806 4323132 SGTC_432 NS 1619 61.3 µM -0.628001903690166 0.254987599470393 no 2525 0.265001346450462 796 4552 A K+/calcium channel activator. SGTC_1449 4112-4002 201 µM -0.628692608717462 0.254757936981455 no 2526 0.264775158979669 807 2059539 SGTC_3229 9132204 49.47 µM -0.629226580556404 0.254580463227231 no 2527 0.264600364745866 809 17682924 SGTC_1436 4092-1007 8.32 µM -0.63033879219892 0.25421101061782 no 2528 0.264236473844071 783 2881121 SGTC_1480 1070-0044 41.2 µM -0.630412062421231 0.254186681712108 no 2529 0.264212510408295 806 3124987 SGTC_3228 9131799 49.47 µM -0.630534555829902 0.25414601129134 no 2530 0.264172450726323 817 17015818 SGTC_2102 5377816 72.7585 µM -0.63067844830209 0.254098240285386 no 2531 0.264125396744795 807 1379702 SGTC_352 k048-0007 5.11 µM -0.630937350778851 0.254012298855828 no 2532 0.264040744331672 828 6811911 SGTC_3085 9117376 49.47 µM -0.631658480916702 0.253773003602923 no 2533 0.263805031902443 809 16480349 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.631827644048223 0.253716886725475 no 2534 0.263749753883491 815 551469 SGTC_564 3555-0129 330 µM -0.632715208465157 0.253422559745404 no 2535 0.263459818242701 806 563260 SGTC_1108 betulinic acid 729.144 nM -0.636098151939065 0.252302382706329 no 2536 0.262356224995216 795 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.636761603552398 0.252083003895814 no 2537 0.262140069964301 810 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2276 7947513 42.08 µM -0.638386051903513 0.251546284278841 no 2538 0.261611204134656 815 2105100 SGTC_1866 st057638 64 µM -0.639265296825108 0.25125603277225 no 2539 0.261325180106415 801 688802 SGTC_31 0508-1974 57.237 µM -0.640070469424938 0.250990389036836 no 2540 0.26106339325861 794 6810525 SGTC_3286 9117135 37.221 µM -0.640880381787356 0.250723331560601 no 2541 0.260800201440558 809 3438150 SGTC_3346 9158254 43.5805 µM -0.644034514937913 0.249684735248888 no 2542 0.259776526391913 834 17639500 SGTC_2725 haloperidol 53.21 µM -0.645430149535001 0.249225909467147 no 2543 0.259324235278663 812 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_834 0312-0008 75.7 µM -0.646824770145353 0.248767865304605 no 2544 0.258872679563325 819 6385573 YIL048W NEO1 SGTC_1963 st076565 50.3 µM -0.647203944248442 0.248643408275111 no 2545 0.258749979465546 832 4914280 SGTC_1422 4031-0024 15.5 µM -0.647480944061019 0.248552509073235 no 2546 0.258660361825645 834 782427 SGTC_1007 4101-0031 70 µM -0.647992384816827 0.248384723158669 no 2547 0.258494937834469 829 1146276 SGTC_276 colchicine 750 µM -0.651277717328415 0.247308360917196 no 2548 0.257433614853587 829 2833 A microtubule depolymerizer. SGTC_2041 5107442 45.335 µM -0.651580007553787 0.247209448033474 no 2549 0.25733607420007 822 793005 SGTC_480 am 92016 50 µM -0.651696126922739 0.247171458047806 no 2550 0.257298610813951 855 2129 K+ channel blocker. SGTC_1265 0819-1001 68.8 µM -0.653033339115325 0.246734196508384 no 2551 0.256867392787491 826 3106768 SGTC_2969 9091408 28.7 µM -0.654135372698003 0.246374148736649 no 2552 0.256512296975422 806 4286311 SGTC_3216 9129716 49.47 µM -0.654647691793876 0.24620686379454 no 2553 0.256347305305576 797 8056934 SGTC_2726 cimetidine 79.27 µM -0.657166132121673 0.245385416661779 no 2554 0.255537049952258 830 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3097 9117246 49.47 µM -0.658527467130245 0.244942000033445 no 2555 0.255099626668808 812 16423892 SGTC_2342 7990637 118.86 µM -0.659158418047098 0.244736631814935 no 2556 0.254897022834096 837 2033102 YER133W GLC7 SGTC_714 4296-0578 26.1 µM -0.659749709616935 0.24454425649425 no 2557 0.254707230428419 823 1589775 SGTC_835 0312-0010 67.2 µM -0.659760454715479 0.244540761355439 no 2558 0.254703782157978 828 1626196 SGTC_3230 9131665 49.47 µM -0.659882566531714 0.244501043019497 no 2559 0.254664596280832 819 15943720 SGTC_1134 3477-0009 42.5 µM -0.662867515672726 0.243531234097602 no 2560 0.253707704050684 823 3973534 SGTC_3334 9142812 21.919 µM -0.663717273590312 0.243255528481961 no 2561 0.253435640806232 815 45283678 SGTC_3330 9141424 71.43 µM -0.664192456247676 0.243101428125584 no 2562 0.253283570538437 807 27261020 SGTC_1417 3966-0327 90.4 µM -0.664438442863016 0.243021676122444 no 2563 0.253204867553528 827 651118 SGTC_951 1171-0579 82.7 µM -0.66485780976391 0.242885744650389 no 2564 0.253070721508863 827 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2732 terfenadine 20 µM -0.664900577103188 0.242871884572757 no 2565 0.253057043299541 837 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_577 r071-0003 38.6 µM -0.665293257796185 0.242744644268852 no 2566 0.252931471047797 845 4568517 YMR134W ERG29 SGTC_1704 st028805 70.8 µM -0.666069893526969 0.242493097323425 no 2567 0.252683213452403 825 2876101 SGTC_972 1319-0219 195 µM -0.667115512402017 0.242154651729998 no 2568 0.252349176126916 831 23903702 SGTC_1699 st031318 29.054 µM -0.667656729143652 0.241979571496773 no 2569 0.252176368468827 818 5340658 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.668594727093093 0.241676297709007 no 2570 0.251877018541345 826 75037 A free radical scavenger. SGTC_606 k015-0008 38.6 µM -0.668632714893949 0.241664019830273 no 2571 0.251864899178716 835 1970475 SGTC_2291 7917025 104.35 µM -0.668664308232556 0.24165380893694 no 2572 0.251854820095119 821 2964612 SGTC_756 0508-1999 28.3 µM -0.669767704943565 0.241297340669318 no 2573 0.251502941918303 838 6753853 SGTC_1042 0350-0096 82 µM -0.670208117599294 0.2411551388166 no 2574 0.251362564912331 828 3122515 SGTC_203 k066-0004 30.888 µM -0.670208870642213 0.241154895710704 no 2575 0.251362324923118 832 6795412 SGTC_2923 7992654 58.14 µM -0.671521191573499 0.24073143979011 no 2576 0.250944282033416 806 2985126 SGTC_628 1636-0253 16 µM -0.672788262865345 0.240322969168923 no 2577 0.25054100292924 828 4456143 SGTC_1041 0206-0046 107 µM -0.673360263946094 0.240138694774075 no 2578 0.250359060946863 835 50494 SGTC_678 1218-2179 85.9 µM -0.674224954282017 0.239860274639761 no 2579 0.250084153451818 848 6820081 YOR116C RPO31 SGTC_695 3505-6186 243 µM -0.674674557504723 0.239715577292125 no 2580 0.249941276227241 834 1819379 SGTC_1439 4092-1168 46 µM -0.674719201535034 0.239701211950877 no 2581 0.249927091382458 838 2886240 SGTC_2025 5147754 141 µM -0.674944801248305 0.239628626746392 no 2582 0.249855417630489 809 315777 YLR208W SEC13 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.675625601526247 0.239409656540183 no 2583 0.249639191363838 837 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_162 k030-0015 37.8 µM -0.676035146682679 0.239277984536714 no 2584 0.249509165252719 848 1809920 YMR134W ERG29 SGTC_2583 asiatic acid 100 µM -0.676683126071047 0.239069734887952 no 2585 0.24930351241273 849 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_478 N-arachidonylglycine 10 µM -0.677717516117777 0.238737504779745 no 2586 0.248975409108618 792 5283389 SGTC_1832 st054113 55 µM -0.678551149297906 0.238469938600185 no 2587 0.248711152181628 817 1251267 SGTC_1401 3807-4679 7.6 µM -0.67882243892287 0.238382899838309 no 2588 0.248625187153842 838 3291456 SGTC_2686 alizarin 95.37 µM -0.680500919240212 0.237844774342275 no 2589 0.248093669987784 809 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2596 sinensetin 100 µM -0.682971131329731 0.237054030517353 no 2590 0.247312542308118 839 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_180 1486-1293 102.781 µM -0.684058199809533 0.236706505477607 no 2591 0.246969207813281 825 4140536 SGTC_1605 st000082 49.1 µM -0.684171124938448 0.236670420505266 no 2592 0.246933556711424 826 1114022 SGTC_2957 9076800 11.52 µM -0.684762346031559 0.236481546531007 no 2593 0.246746949832826 835 16459615 SGTC_364 0083-0097 67.7 µM -0.685546273446747 0.236231237759436 no 2594 0.246499635613162 828 5207356 SGTC_637 1181-0519 7.26 µM -0.68792088430598 0.235473913401554 no 2595 0.245751302144183 832 6252091 YGR060W ERG25 SGTC_2450 5739737 12.93 µM -0.688608178552091 0.23525496788626 no 2596 0.245534936466133 836 2262825 SGTC_2421 5690543 90.72 µM -0.689071902000135 0.235107306955692 no 2597 0.245389010484369 836 3397993 SGTC_1870 st057514 26.5 µM -0.689769956359955 0.234885125872548 no 2598 0.245169432417616 841 5393161 SGTC_3027 9089541 49.47 µM -0.689838400037553 0.234863347441486 no 2599 0.245147908651039 833 9943819 SGTC_2207 7258803 200 µM -0.690984127907011 0.234498948400904 no 2600 0.244787757794603 839 3666799 SGTC_151 3013-0144 2.285 µM -0.692919466070365 0.23388412461702 no 2601 0.244180046398144 848 906558 YHR107C CDC12 SGTC_2170 morpholine 200 µM -0.698052737989142 0.232257706658154 no 2602 0.242572106653725 828 121171 Reacts with secondary amines. SGTC_1093 fluphenazine 7.97 µM -0.700067145061749 0.231621188519839 no 2603 0.241942686406168 843 6602611 An atypical antipsychotic. SGTC_2724 maprotiline 69.64 µM -0.700633097478085 0.231442532350854 no 2604 0.241766008856406 843 4011 A tricyclic antidepressant. SGTC_3250 9135583 49.47 µM -0.700676816866906 0.231428734497022 no 2605 0.241752363565603 826 7699353 SGTC_2050 5263056 171 µM -0.70110061795838 0.231295006505966 no 2606 0.241620112359949 827 763468 YGL055W OLE1 SGTC_1125 tnp00248 1.32998 µM -0.702167025275393 0.230958698587439 no 2607 0.241287503547124 853 24207736 SGTC_846 0335-0850 148 µM -0.702326743688097 0.230908352450233 no 2608 0.241237709349333 829 6819598 SGTC_284 0988-0104 32.6 µM -0.703141728610983 0.230651549868989 no 2609 0.240983714658898 845 4666532 SGTC_2331 7980721 200 µM -0.703981173062653 0.230387206973138 no 2610 0.240722249144057 830 2981221 SGTC_1709 st033179 39.1045 µM -0.704074924026756 0.230357695107615 no 2611 0.240693057699591 842 573381 SGTC_2153 5569715 200 µM -0.704113992598916 0.230345397335971 no 2612 0.240680893400881 832 2054701 SGTC_2769 toremifene 3.73 µM -0.704348634929379 0.230271545749208 no 2613 0.240607842757126 837 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2537 larixol 68.93 µM -0.704953994850377 0.230081075262155 no 2614 0.240419433233065 839 6708759 SGTC_1728 st035614 33.7865 µM -0.706080867788348 0.229726750775293 no 2615 0.240068924444206 840 15945546 SGTC_3293 9120939 62.045 µM -0.70704486404882 0.229423882547905 no 2616 0.239769298956318 839 934087 SGTC_2692 st077426 47.7 µM -0.707363972998178 0.229323674260954 no 2617 0.239670159748859 838 25238571 SGTC_3316 9136639 10.545 µM -0.707706977908784 0.229215989404949 no 2618 0.239563621613075 831 4903665 SGTC_1037 k284-1091 78.7 µM -0.707741501830273 0.229205152345226 no 2619 0.239552899833713 831 3334711 SGTC_2198 6589944 200 µM -0.70778184800615 0.229192488043817 no 2620 0.239540370221885 830 5290268 SGTC_1790 st045711 43.5 µM -0.70952414599706 0.228645970893624 no 2621 0.238999636439156 797 585119 SGTC_640 3381-0960 37.1 µM -0.709694924428164 0.228592441200653 no 2622 0.238946670152425 847 1745025 SGTC_1330 1469-0054 61.8 µM -0.71036208900675 0.228383389085918 no 2623 0.238739813101925 833 7102664 SGTC_516 3992-2719 87.3 µM -0.71356834279861 0.227380228385054 no 2624 0.23774706941301 832 5350887 YDR037W KRS1 SGTC_989 1501-0895 10.3 µM -0.713949672489134 0.227261084773232 no 2625 0.237629150190655 837 2830112 SGTC_1622 st003707 19.4 µM -0.714062315200628 0.227225897132098 no 2626 0.237594323636326 809 10140899 SGTC_3298 9116858 71.43 µM -0.714204506787394 0.227181483316442 no 2627 0.237550365244207 878 2506942 SGTC_1380 2291-0730 164 µM -0.716423696027367 0.226488949721485 no 2628 0.236864883795852 828 2999191 SGTC_1925 st057770 10.1 µM -0.717186234578789 0.226251262777887 no 2629 0.236629595902529 834 5989122 SGTC_2259 7964009 200 µM -0.719002929337834 0.225685558446592 no 2630 0.236069557392969 829 313134 SGTC_1280 0880-0253 10.1 µM -0.719338242705464 0.225581232076585 no 2631 0.235966269122756 848 6836607 SGTC_2768 sulfasalazine 50.2 µM -0.719434165272935 0.225551392617181 no 2632 0.235936726191905 858 5384001 An antioxidant and salicylic acid derivative. SGTC_14 0354-0009 295 µM -0.721401214689335 0.224939978418486 no 2633 0.235331349735792 855 1713507 SGTC_1626 st003712 1.76 µM -0.723278193666905 0.224357437545825 no 2634 0.234754493597144 863 24207035 SGTC_152 4469-0003 551.229 µM -0.72361752898996 0.224252212610824 no 2635 0.234650288417942 835 697280 SGTC_2426 5582046 32.21 µM -0.726955923000747 0.223218500653649 no 2636 0.233626478701557 840 2251934 SGTC_1930 st074634 34.3 µM -0.7277015398463 0.222987996362781 no 2637 0.23339815376596 856 684253 YOR116C RPO31 SGTC_2560 caryophyllene 100 µM -0.728084508177202 0.222869656043539 no 2638 0.233280928241897 848 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1625 st003711 30.1 µM -0.728094507533656 0.222866566640715 no 2639 0.233277867904907 858 24207034 YER133W GLC7 SGTC_616 4092-0450 108 µM -0.728300400029484 0.222802959484752 no 2640 0.233214858760336 865 787165 SGTC_3186 9110464 49.47 µM -0.728763017717527 0.222660078973174 no 2641 0.233073318638645 836 17018021 SGTC_2673 kobusone 100 µM -0.728914203000739 0.22261339638493 no 2642 0.233027073112276 864 6710676 An epoxy ketone and protein crosslinker. SGTC_359 0081-0058 15.9 µM -0.729754278523582 0.222354101769364 no 2643 0.232770198254495 854 3494159 SGTC_194 1486-1323 56.904 µM -0.732354946911165 0.221552482206932 no 2644 0.231975974939117 845 5178754 SGTC_2121 5257820 149.641 µM -0.733661893842189 0.221150258596436 no 2645 0.231577414214006 822 791256 SGTC_3273 9137859 49.47 µM -0.734529556420206 0.22088345925172 no 2646 0.231313026645378 889 2377234 SGTC_1822 st052468 42 µM -0.734713463189943 0.220826933059772 no 2647 0.231257009599908 853 2873678 SGTC_964 1287-0107 19.4 µM -0.734727560203592 0.220822600496926 no 2648 0.231252716035172 848 51516812 YPR165W RHO1 SGTC_341 1486-1430 230 µM -0.735976423527051 0.220438969224128 no 2649 0.230872522952359 862 2054753 YPL210C SRP72 SGTC_2074 5212007 75.395 µM -0.736609203970784 0.22024473486858 no 2650 0.230680018089117 834 758611 SGTC_2614 arthonioic acid 13.39 µM -0.736875906646992 0.220162898877754 no 2651 0.230598908504673 859 6710684 SGTC_800 3448-7362 155 µM -0.73723040019998 0.220054151824007 no 2652 0.230491124642199 855 15991913 SGTC_3135 9127742 49.47 µM -0.73758804495114 0.21994446931855 no 2653 0.230382411198656 855 3643468 SGTC_2000 st075254 36.4 µM -0.738273120977076 0.219734457799965 no 2654 0.230174248390693 827 17234175 SGTC_3280 9140961 49.47 µM -0.739254414036817 0.219433840965595 no 2655 0.229876262348493 872 4901226 SGTC_921 1561-0023 372 µM -0.741133576275287 0.218858824002991 no 2656 0.229306226549725 845 24050882 SGTC_2651 TUB2.036 5 µM -0.743331164900572 0.218187470710197 no 2657 0.228640603919112 844 15992207 YFL037W TUB2 SGTC_2427 5545055 42.75 µM -0.743444200808607 0.218152970877978 no 2658 0.228606396095397 842 5372858 SGTC_533 1222-0222 6.71 µM -0.744325070504359 0.217884227259627 no 2659 0.228339918815358 875 3982874 SGTC_1274 0865-0114 173 µM -0.744413851488009 0.217857151757035 no 2660 0.228313070824268 840 870624 SGTC_18 0111-0177 500 nM -0.744594439998841 0.21780208373631 no 2661 0.22825846506944 848 721752 SGTC_3 0833-0587 95.581 µM -0.745877721410244 0.217410995764747 no 2662 0.227870642202281 853 5382644 SGTC_2324 6149169 200 µM -0.749732428665145 0.216238690788445 no 2663 0.226707936206054 847 2888231 SGTC_3099 9120367 49.47 µM -0.749742559292067 0.216235614662001 no 2664 0.2267048848945 863 24824940 SGTC_3134 9127454 49.47 µM -0.751241783028348 0.21578066045171 no 2665 0.226253579201963 866 24262820 SGTC_3267 9137951 49.47 µM -0.752145206743578 0.215506775736372 no 2666 0.225981870220933 892 16643986 SGTC_2192 5915882 198.485 µM -0.752455026641329 0.215412896232159 no 2667 0.225888732908135 844 2876149 SGTC_1263 0774-1208 64.8 µM -0.752526895338922 0.215391122462019 no 2668 0.225867131015062 860 906585 SGTC_1840 st055363 71 µM -0.75310034743442 0.215217431735023 no 2669 0.225694807831218 866 676033 SGTC_809 3998-0021 90 µM -0.753833923548621 0.214995360207158 no 2670 0.225474475620592 862 715485 SGTC_3165 9101544 49.47 µM -0.75478051213505 0.214709001293306 no 2671 0.225190344358678 853 5002184 SGTC_2030 5175110 200 µM -0.756508072247719 0.21418695716153 no 2672 0.224672317227429 866 2831986 SGTC_791 1348-1292 225 µM -0.756605590780796 0.214157510483143 no 2673 0.22464309543375 870 5437054 SGTC_2838 9002687 71.43 µM -0.757502673199357 0.213886738166415 no 2674 0.224374382482697 868 6457060 SGTC_520 3584-0023 682 µM -0.759475489931388 0.213291971540258 no 2675 0.223784085265373 843 1340790 SGTC_601 0986-0029 62.9 µM -0.759796827926538 0.213195185673334 no 2676 0.223688019651911 840 24747981 SGTC_1642 st009582 77.7 µM -0.759915499475766 0.213159448699941 no 2677 0.223652548123493 863 6739311 SGTC_2316 5844804 197.44 µM -0.760289553495427 0.213046828234737 no 2678 0.223540762410306 859 776813 SGTC_2037 5169046 200 µM -0.760336894701792 0.213032577183934 no 2679 0.22352661679853 852 5718022 SGTC_2611 pyromycin 23.93 µM -0.76157513025672 0.212660030589093 no 2680 0.223156811325386 864 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1608 st001473 40.5 µM -0.762769463678068 0.21230105348625 no 2681 0.222800447696471 868 7292267 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.763868190941453 0.211971125404054 no 2682 0.222472897476953 852 2724278 An inhibitor of dopamine biosynthesis. SGTC_2135 5326629 150.42 µM -0.763985582025284 0.21193589270893 no 2683 0.222437917343658 872 5020077 SGTC_812 4251-0442 148 µM -0.764425997445361 0.211803740956298 no 2684 0.222306710552514 873 5723007 SGTC_977 1348-1378 135 µM -0.764639534145176 0.211739684153886 no 2685 0.22224311045491 851 X977 SGTC_883 0850-0245 24.6 µM -0.764841714824796 0.211679044383994 no 2686 0.222182902221781 847 6823229 YPR165W RHO1 SGTC_2119 5528445 120.635 µM -0.765638768562042 0.211440084208813 no 2687 0.221945634948048 863 791935 SGTC_2141 5621638 7.665 µM -0.767427023006715 0.210904532924337 no 2688 0.221413833434891 853 2856238 SGTC_385 1494-0393 12.4 µM -0.769417219885344 0.210309439574976 no 2689 0.220822834646293 870 3090647 SGTC_160 3453-0671 289.699 µM -0.769535148448936 0.210274208453116 no 2690 0.220787843547274 872 5322268 SGTC_2034 5197015 53.07 µM -0.769571962799629 0.210263210887126 no 2691 0.220776920850873 865 780676 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.770510641912905 0.209982913015244 no 2692 0.220498522407646 855 688664 SGTC_2409 alverine citrate 63.97 µM -0.771107339129042 0.209804848166557 no 2693 0.220321655410789 848 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2314 7727897 200 µM -0.77157204785095 0.209666232491733 no 2694 0.220183967472663 834 900724 SGTC_3179 9107801 49.47 µM -0.773490699827176 0.209094497726631 no 2695 0.219616015326255 833 4818259 SGTC_394 menadione 8.33 µM -0.77399296315239 0.208944981171153 no 2696 0.219467476291194 867 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1939 st074455 53.6 µM -0.774773391015851 0.208712784036886 no 2697 0.219236787606482 863 1644229 SGTC_2782 7736369 71.43 µM -0.77504524605 0.208631935979688 no 2698 0.219156462020419 864 2950836 YOL077C BRX1 SGTC_150 3970-0969 77.2 µM -0.776546904598977 0.208185684473727 no 2699 0.218713068745623 884 6615640 SGTC_1934 st074720 32.6 µM -0.776723157041066 0.208133344068703 no 2700 0.218661060733908 856 17250992 SGTC_1479 0549-0158 134 µM -0.779384307925414 0.207344025708921 no 2701 0.217876682365632 873 5440202 SGTC_768 0384-0033 77.3 µM -0.779593267927157 0.207282121555083 no 2702 0.21781515986725 850 3965305 YMR134W ERG29 SGTC_1591 genipin 88.4 µM -0.7799596980766 0.207173593445883 no 2703 0.217707298830928 892 442424 A DNA cross-linking agent. SGTC_1013 4112-3890 241 µM -0.779975792358843 0.207168827463507 no 2704 0.217702562083546 865 705171 SGTC_1290 0986-0249 10.2 µM -0.781267599126428 0.206786497666218 no 2705 0.217322561253836 863 53329 SGTC_2778 tioconazole 65.09 nM -0.783981004129874 0.205984785792094 no 2706 0.216525628315052 867 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.786629909625871 0.205203912258907 no 2707 0.215749272579131 857 6857784 SGTC_103 0844-0104 51.839 µM -0.786681849461951 0.205188618465235 no 2708 0.215734065914708 875 5375804 SGTC_2029 5175081 200 µM -0.787928041757337 0.204821877638282 no 2709 0.215369398800669 860 1380876 SGTC_1977 st070720 65.3 µM -0.789649902472908 0.204315794675939 no 2710 0.214866128101175 858 682188 SGTC_995 3931-2021 34.6 µM -0.790077457677865 0.204190244704783 no 2711 0.214741266920969 883 730143 SGTC_1018 4259-0013 28.1 µM -0.790583427640986 0.204041727910565 no 2712 0.214593560351856 870 6801262 SGTC_1300 1094-0077 113 µM -0.792023704019869 0.203619317680298 no 2713 0.21417342745943 864 5532636 SGTC_1804 st050076 49.1 µM -0.792912655573374 0.20335886273885 no 2714 0.213914356684905 876 3895976 SGTC_3355 9151058 44.0485 µM -0.793534316213024 0.20317683984408 no 2715 0.213733292051172 864 17015728 SGTC_2728 chlorpromazine 9.18 µM -0.795264683851109 0.202670698725116 no 2716 0.213229776141195 904 2726 A thorazine and dopamine antagonist. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.795295495859959 0.202661692893297 no 2717 0.213220816494742 887 364106 SGTC_1805 st050013 60.3 µM -0.795399217915602 0.202631378439069 no 2718 0.213190657369548 858 4037144 SGTC_2320 7373003 200 µM -0.795589997323617 0.202575627137942 no 2719 0.213135191189883 855 5415828 SGTC_1172 0370-0043 85 µM -0.795725121112585 0.202536145577612 no 2720 0.21309591111836 867 376585 SGTC_2702 st077768 96.8 µM -0.795823814900208 0.202507311336521 no 2721 0.213067223805422 850 6484119 SGTC_2474 5321570 43.32 µM -0.796796099179978 0.202223381301271 no 2722 0.212784730484051 871 2841384 SGTC_1572 epiandrosterone 68.9 µM -0.803025876947486 0.200409797020465 no 2723 0.210979889030036 861 441302 A steroid. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.807259186938069 0.199183009123172 no 2724 0.209758586243851 887 521171 SGTC_3328 9140624 29.0385 µM -0.807672864892099 0.199063370821709 no 2725 0.209639464198933 870 4904392 SGTC_3245 9134821 49.47 µM -0.808823607421166 0.198730796553709 no 2726 0.209308307546872 892 17014901 SGTC_3030 9087619 49.47 µM -0.809436210975458 0.198553885704612 no 2727 0.209132140292489 854 25236973 SGTC_615 k087-0205 167 µM -0.809594591624588 0.198508163174124 no 2728 0.209086608756647 875 9642773 SGTC_2177 5811945 192 µM -0.810750475286638 0.198174666255848 no 2729 0.208754490172441 876 5343475 SGTC_960 1222-0186 7.7 µM -0.812623184346139 0.19763506849765 no 2730 0.208217067427937 886 3126296 SGTC_3005 9076496 71.4286 µM -0.813866830569829 0.197277218541895 no 2731 0.2078606222068 873 21368410 SGTC_2489 cantharidin 73.42 µM -0.815115797286609 0.19691823240749 no 2732 0.207503014978465 880 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_271 rotenone 740 µM -0.815631476699469 0.196770127903621 no 2733 0.207355470503042 885 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1000 4048-0884 8.67 µM -0.816912623113943 0.196402471323434 no 2734 0.206989181734785 892 13040088 SGTC_157 1348-1695 65.819 µM -0.817560489003465 0.196216708834561 no 2735 0.206804098178071 872 5380510 SGTC_2266 7929956 200 µM -0.81985149728438 0.195560663312996 no 2736 0.206150384836276 882 2967153 SGTC_2628 lathosterol 100 µM -0.821880743955484 0.194980688763794 no 2737 0.205572386655037 875 6710616 SGTC_786 4544-0069 423 µM -0.823290067646229 0.194578509086227 no 2738 0.205171530245804 877 748821 YLR208W SEC13 SGTC_1696 st025591 34.7925 µM -0.828305426578894 0.193151372365509 no 2739 0.203748775200657 866 2787147 SGTC_2932 9016711 44.54 µM -0.828823249111815 0.193004389084883 no 2740 0.203602215242513 895 7117328 SGTC_1174 0739-0097 51.1 µM -0.831428263524621 0.192265995611469 no 2741 0.202865868975072 888 728447 SGTC_2902 5787006 60.46 µM -0.831444385520853 0.192261431204855 no 2742 0.202861316810495 886 591003 SGTC_1102 cgs 12066b 26.1 µM -0.832446952343025 0.191977718006762 no 2743 0.202578354568461 862 6438352 A 5-HT1B full agonist. SGTC_1267 0828-0272 9.49 µM -0.832601679930515 0.191933954973976 no 2744 0.202534705621009 886 745334 SGTC_1343 1487-0095 224 µM -0.833847091186221 0.191581926227878 no 2745 0.20218357752987 896 4560101 YGL055W OLE1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.835376301288279 0.191150220079723 no 2746 0.201752934416703 872 6708514 SGTC_2652 actinonin 100 µM -0.836491220755115 0.190835847196498 no 2747 0.201439306821655 883 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1198 1612-1005 86.7 µM -0.836576388058678 0.190811845694013 no 2748 0.20141536121993 900 6998509 SGTC_753 1322-0200 289 µM -0.837943106233087 0.190426936143616 no 2749 0.201031328731869 883 5403907 SGTC_2984 9022109 38.96 µM -0.84131676812257 0.189478853121527 no 2750 0.200085249652774 904 6459207 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.841770908531478 0.189351450544959 no 2751 0.19995809935048 860 804 An inhibitor of viral and cellular DNA polymerases. SGTC_438 sphingosine 6.67 µM -0.842005227593831 0.18928573632021 no 2752 0.199892513668639 892 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1129 3453-1384 223 µM -0.842267240270064 0.189212272116456 no 2753 0.199819191893548 905 1084452 SGTC_2212 7123476 200 µM -0.844490001541147 0.188589751485757 no 2754 0.199197824094238 864 1085715 SGTC_1227 3909-8010 46.6 µM -0.847531861483021 0.187739878135823 no 2755 0.198349367829294 883 15982272 SGTC_967 1306-0166 352 µM -0.848141863096935 0.187569733361995 no 2756 0.198179484926464 882 4437607 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.848365845092822 0.187507283079899 no 2757 0.198117128930181 895 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1910 st062352 60.4 µM -0.848731817814699 0.187405270837247 no 2758 0.198015268585453 896 2245730 SGTC_1520 flindersine 88 µM -0.851067671637805 0.186754977055811 no 2759 0.197365881234198 889 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_148 3253-0744 288.01 µM -0.852237555506745 0.186429810954312 no 2760 0.197041128157493 883 6893655 SGTC_2594 a-mangostin 100 µM -0.852339967803128 0.186401362432842 no 2761 0.19701271449261 897 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2643 anethole 100 µM -0.853711292046619 0.186020689301908 no 2762 0.196632487951518 915 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2359 9039622 200 µM -0.855071439316329 0.18564359531043 no 2763 0.196255799897305 900 6463596 SGTC_704 1310-0270 142 µM -0.856671050733984 0.185200718474702 no 2764 0.195813353350481 888 5718033 SGTC_89 0302-0250 142.109 µM -0.856750431650067 0.185178757759057 no 2765 0.195791412662594 908 4203518 YLR208W SEC13 SGTC_2238 6671620 73.2395 µM -0.858874895714613 0.184591626140725 no 2766 0.195204770530168 873 729941 SGTC_3081 9117243 49.47 µM -0.860168598958986 0.184234657101284 no 2767 0.194848055671203 893 45595589 SGTC_992 3909-8734 162 µM -0.860248689637624 0.184212571965229 no 2768 0.19482598517978 893 4288319 SGTC_221 trifluoperazine 10.304 µM -0.860363892159586 0.184180807570413 no 2769 0.194794241626779 906 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2736 butenafine 14.65 µM -0.8613169997689 0.183918141279474 no 2770 0.19453173767562 886 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_706 4262-0057 46.9 µM -0.862671563007085 0.183545239688802 no 2771 0.194159035842676 903 883298 SGTC_23 0213-0011 39.996 µM -0.862859672149097 0.18349349187288 no 2772 0.194107312894858 902 627608 SGTC_2927 9011802 47.9 µM -0.862897836217411 0.183482994252152 no 2773 0.194096820233994 881 43912568 SGTC_1812 st052057 4.327 µM -0.863061300836659 0.18343803500122 no 2774 0.194051881901112 903 3645418 SGTC_304 1310-0298 97 µM -0.863549579871562 0.18330377980774 no 2775 0.193917686043355 897 1550234 SGTC_3241 9133421 49.47 µM -0.863641775090162 0.183278437068294 no 2776 0.193892353978221 924 17018221 SGTC_2415 st077333 57.7 µM -0.863814084653006 0.183231078253704 no 2777 0.19384501466289 874 2766255 SGTC_2779 methotrexate 400 µM -0.864023807509564 0.183173446795674 no 2778 0.19378740614585 887 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2683 piperine 63.03 µM -0.864867582963444 0.182941693110701 no 2779 0.193555735973649 898 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2682 pyrogallin 40.03 µM -0.865137489802826 0.182867598400558 no 2780 0.193481665007757 875 822798 An ATP competetive kinase inhibitor. SGTC_215 1287-0124 461.5 µM -0.86530463490461 0.182821723191015 no 2781 0.193435803780811 897 5560863 SGTC_1834 st055981 52.8 µM -0.872479450669983 0.180859275334734 no 2782 0.1914734369053 874 471719 YDL150W RPC53 SGTC_2712 st079126 47.7 µM -0.873929036858221 0.180464395239872 no 2783 0.19107845023131 892 3152970 SGTC_55 0767-0285 6.563 µM -0.874586047550669 0.180285597971269 no 2784 0.19089959108025 902 3116166 SGTC_1933 st074711 15.9 µM -0.876102986731018 0.179873206700355 no 2785 0.19048702461568 883 17250958 SGTC_499 genistein 192 µM -0.876765594611454 0.179693257859811 no 2786 0.190306985108234 912 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_559 1550-0661 158 µM -0.878573694495613 0.179202795829869 no 2787 0.189816231974808 897 5830875 SGTC_1495 4469-0029 237 µM -0.880127329662354 0.178782032709417 no 2788 0.189395167690909 874 793680 SGTC_2381 9035592 200 µM -0.88047016296452 0.178689268735497 no 2789 0.189302330914962 914 4749657 SGTC_1750 st081859 2.357 µM -0.882207154121518 0.178219738844626 no 2790 0.188832396943551 884 5291695 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.882903226268261 0.178031800492446 no 2791 0.188644280162734 896 676296 Flavone; oxidizing agent. SGTC_1780 st038448 24.544 µM -0.882999742505171 0.178005751132793 no 2792 0.188618205317717 913 728868 YDL195W SEC31 SGTC_3169 9102970 49.47 µM -0.883316767390514 0.177920204253341 no 2793 0.188532573451078 913 17027839 SGTC_1996 st072960 66.8 µM -0.886550399938508 0.177049113296607 no 2794 0.187660504005024 881 1719405 SGTC_481 bay k-8644 50 µM -0.887521109577743 0.176788145753073 no 2795 0.187399203100493 912 2303 A calcium channel antagonist. SGTC_1130 3454-2858 15.9 µM -0.887850382089718 0.176699678722825 no 2796 0.187310618840805 902 715628 YIL048W NEO1 SGTC_428 3448-4153 16.5 µM -0.88819282643075 0.176607702459148 no 2797 0.187218518428726 881 3834874 SGTC_1489 4065-0444 182 µM -0.888713113018677 0.176468017948172 no 2798 0.187078640946136 871 2877968 SGTC_287 k060-0039 29.6 µM -0.893538990854779 0.175175717152549 no 2799 0.185784300703783 892 5861974 SGTC_717 1532-0246 73.2 µM -0.893695224211912 0.175133980655861 no 2800 0.185742490665219 901 9561992 SGTC_1051 3253-3903 78 µM -0.893953325846596 0.175065044678868 no 2801 0.185673432163998 888 5509239 SGTC_2372 9071633 200 µM -0.894337021784654 0.174962595729914 no 2802 0.185570798695771 913 21321366 SGTC_1156 4092-0367 4.88 µM -0.89441311266941 0.174942283561627 no 2803 0.185550449598227 901 1357585 SGTC_3320 9137005 35.139 µM -0.895804918360786 0.174571010433274 no 2804 0.185178481304938 894 4908713 SGTC_1842 st055362 61.2 µM -0.89639350089862 0.174414152907633 no 2805 0.185021318579669 880 676032 SGTC_1820 st053765 18.6 µM -0.898218708921396 0.173928303629966 no 2806 0.184534480510282 890 3690829 SGTC_2063 5246145 200 µM -0.899424788589603 0.173607731851809 no 2807 0.184213220234646 913 711240 SGTC_2173 5763948 167 µM -0.899541807894871 0.173576648548522 no 2808 0.184182068644615 891 2867177 SGTC_2880 9042983 58.44 µM -0.900902347594916 0.173215514583766 no 2809 0.183820121462355 919 6464714 SGTC_686 1319-0111 510 µM -0.901585596707269 0.173034337410176 no 2810 0.183638522520361 933 4562600 SGTC_226 1,3-diallylurea 8.28947 mM -0.904248407429452 0.172329392465027 no 2811 0.182931848586805 897 74537 YKL182W FAS1 SGTC_1063 disulfiram 1.84 µM -0.908779370278643 0.171134096036235 no 2812 0.18173329909912 928 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1783 st039459 87.517 µM -0.910126404975792 0.170779764743584 no 2813 0.181377925328268 908 729761 SGTC_2200 6600604 21.907 µM -0.911975427348044 0.170294153062301 no 2814 0.180890826571925 930 2904777 SGTC_1320 1313-0481 95.3 µM -0.912051481748469 0.17027419773353 no 2815 0.180870808687896 905 6813365 YLR208W SEC13 SGTC_1713 st033146 12.748 µM -0.91364060990069 0.1698575813318 no 2816 0.180452860149754 914 674619 SGTC_2945 9067681 61.76 µM -0.916718019005522 0.169052647431519 no 2817 0.179645210682994 935 16456930 SGTC_2752 diclazuril 33.15 µM -0.917087686899816 0.168956121363181 no 2818 0.17954834637964 892 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_4 0960-0234 25.671 µM -0.917610512446111 0.168819663893507 no 2819 0.179411406139872 880 6821112 SGTC_1506 4226-2149 212 µM -0.920587287027734 0.168044075598243 no 2820 0.17863297101532 915 991114 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.920729750486617 0.168007014825474 no 2821 0.178595769817861 921 115019 SGTC_2989 9073649 71.4286 µM -0.921123722542458 0.167904553416744 no 2822 0.178492918089429 903 21367202 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.922288372692681 0.167601894885335 no 2823 0.178189088658993 890 17037758 SGTC_1094 duloxetine 25.4 µM -0.923425572696089 0.167306709142524 no 2824 0.177892735056151 888 60834 A selective serotonin reuptake inhibitor. SGTC_37 0566-0070 1.56 µM -0.925366304338585 0.166803723108169 no 2825 0.177387700005217 907 1626686 SGTC_2343 7990716 14.84 µM -0.928528090395589 0.165986363914293 no 2826 0.176566851793938 921 6456862 SGTC_1615 st002656 86.5 µM -0.92942968766371 0.165753765373722 no 2827 0.17633322416776 916 1584458 SGTC_2038 4100038 30.985 µM -0.930260121289246 0.165539712509561 no 2828 0.176118210049029 879 3596803 SGTC_3276 9139060 49.47 µM -0.930820243746801 0.165395436159016 no 2829 0.175973278090114 927 4870619 SGTC_408 cantharidin 100 µM -0.932803346846227 0.164885282555852 no 2830 0.17546075644059 894 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_566 0958-0068 16.5 µM -0.933185185221649 0.164787171695617 no 2831 0.175362181238107 888 6815365 SGTC_1416 3966-0321 25.3 µM -0.933590102289099 0.164683172238976 no 2832 0.175257686418862 908 582530 YLR208W SEC13 SGTC_2900 5328528 85.29 µM -0.933950502903258 0.164590642226868 no 2833 0.175164712946696 918 795359 SGTC_447 ml7 120 µM -0.934170652221404 0.164534137206178 no 2834 0.175107935855507 925 4216 Selective myosin light chain kinase inhibitor. SGTC_2549 cedrol 20.94 µM -0.934406967328938 0.164473496956525 no 2835 0.175047002557396 904 6708665 A sedative which affects the nervous system. SGTC_375 3970-0961 9.27 µM -0.934511109263696 0.164446777945133 no 2836 0.175020154073716 889 2898222 SGTC_1475 4092-1048 11.7 µM -0.93454382461683 0.1644383849629 no 2837 0.175011720377328 936 2881759 SGTC_3051 9093778 49.47 µM -0.935060781586775 0.164305798750795 no 2838 0.174878488182314 942 17217378 SGTC_1777 st045864 34.765 µM -0.936323822927708 0.16398215266751 no 2839 0.174553243011257 936 4691462 SGTC_1445 4239-0156 97.7 µM -0.938105999769206 0.163526185571745 no 2840 0.174094969406324 939 4008346 SGTC_1948 st076329 66.6 µM -0.938651559599426 0.16338676971776 no 2841 0.173954835760948 903 24208413 SGTC_2370 9071495 200 µM -0.938679643511262 0.163379595065182 no 2842 0.173947624009862 940 21791103 SGTC_882 0843-0131 351 µM -0.938991286991403 0.163299992624525 no 2843 0.173867608915733 907 5425421 SGTC_2844 9010103 25.97 µM -0.939486045088038 0.163173669366163 no 2844 0.173740626860492 913 2480525 SGTC_1814 st052110 31.539 µM -0.93975118650975 0.163105998731093 no 2845 0.173672601318965 920 674163 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.940961014010021 0.162797452425346 no 2846 0.173362419161771 899 6312947 SGTC_3208 9114115 49.47 µM -0.942315783947853 0.162452391794635 no 2847 0.173015494739756 913 650895 SGTC_3045 9092950 49.47 µM -0.944198636638847 0.161973619221162 no 2848 0.172534075898666 908 44120432 SGTC_1776 st049249 45.9 µM -0.953239454888209 0.159687532582599 no 2849 0.170234379997813 921 1822314 SGTC_2429 5902844 64.44 µM -0.955530056404112 0.15911169334286 no 2850 0.169654856593435 916 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1044 1222-0021 1.78 µM -0.956056739881277 0.158979481837334 no 2851 0.169521784543371 898 4306703 SGTC_1454 4239-0054 42.6 µM -0.956284343737813 0.158922369522173 no 2852 0.169464298795121 900 1340767 SGTC_1961 st076550 68.7 µM -0.956445004014085 0.15888206336155 no 2853 0.169423728472786 916 1579337 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.95798588725904 0.158495829648038 no 2854 0.169034937513087 920 66535 A nucleotide analog. SGTC_130 0136-0219 337.655 µM -0.960551965838557 0.157853991033128 no 2855 0.168388745188059 926 234244 SGTC_524 r073-0010 27.8 µM -0.962874518788639 0.157274537749837 no 2856 0.1678052492217 921 2772106 SGTC_387 norethindrone acetate 66.7 µM -0.963359601382495 0.157153691351387 no 2857 0.167683546251766 939 541197 SGTC_2191 5911152 200 µM -0.964355903912609 0.156905678631378 no 2858 0.167433761004754 908 2875902 SGTC_1964 st076914 61 µM -0.964550408936753 0.156857289945098 no 2859 0.167385024198737 940 24208661 SGTC_2076 5212012 200 µM -0.965848181118797 0.156534683351446 no 2860 0.167060077556964 911 604802 SGTC_355 1311-2252 105 µM -0.966223471366201 0.156441473343801 no 2861 0.166966185238509 935 5338538 SGTC_1283 0922-0125 16.4 µM -0.966529931144884 0.156365385722247 no 2862 0.166889538579163 898 3360884 SGTC_2094 5332512 191.667 µM -0.967147720360271 0.156212075546972 no 2863 0.166735096345832 926 755774 SGTC_713 1488-1073 324 µM -0.968033823854151 0.155992353615633 no 2864 0.166513738795803 932 3312542 SGTC_1862 st057513 3.81 µM -0.970813570574867 0.15530439839815 no 2865 0.165820561787421 923 5393163 SGTC_1962 st076595 64.5 µM -0.973276008149823 0.154696648634009 no 2866 0.165208071589402 915 279619 SGTC_470 aa-861 153 µM -0.973996882941686 0.15451902859786 no 2867 0.165029043455732 912 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3237 9133362 49.47 µM -0.977324476427068 0.15370087371505 no 2868 0.164204269621585 933 43845137 SGTC_1068 loratadine 26.9 µM -0.978930981429312 0.153306910986103 no 2869 0.163807041461003 945 3957 A H1 histamine antagonist. SGTC_2793 7325131 81.82 µM -0.979221114014767 0.153235833248541 no 2870 0.163735369147977 912 4176441 SGTC_3290 9121031 71.43 µM -0.979974310073686 0.153051414476375 no 2871 0.163549399925134 919 17014854 SGTC_1202 1988-0068 29.6 µM -0.980992860131199 0.152802258324926 no 2872 0.163298131241953 917 2850480 SGTC_1764 st044502 93.5 µM -0.981438054952957 0.152693439980635 no 2873 0.163188383819343 922 8407 SGTC_19 0279-0214 38.434 µM -0.98237876984344 0.152463671472404 no 2874 0.16295664070132 928 3566274 YBR002C RER2 SGTC_2921 7974240 10.71 µM -0.982808986141382 0.15235866814694 no 2875 0.162850729162879 915 2979074 YDR527W RBA50 SGTC_2867 9039098 71.43 µM -0.98581406055948 0.151626555498422 no 2876 0.162112182357459 910 6463460 SGTC_3143 9086658 49.47 µM -0.986504417779171 0.151458697751487 no 2877 0.16194282422206 914 25236626 SGTC_2733 amorolfine 100 µM -0.986678439762954 0.151416404470311 no 2878 0.161900151419372 970 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_748 act1.228 77.9 µM -0.987926806027526 0.151113239113848 no 2879 0.161594248064698 925 4421505 YNR035C ARC35 SGTC_2934 9036370 36.88 µM -0.9880934802445 0.151072792914284 no 2880 0.161553434252602 899 6462800 SGTC_2058 5236698 133 µM -0.988223706814412 0.151041196340175 no 2881 0.161521550117855 903 766665 SGTC_118 0083-0097 135.343 µM -0.990186486726969 0.150565504188204 no 2882 0.161041488161315 947 5207356 SGTC_2194 5927483 104.545 µM -0.993779244955545 0.149697364003955 no 2883 0.16016517637293 904 760979 SGTC_2142 5622915 118.518 µM -0.996521323435253 0.149037030221035 no 2884 0.159498455884175 927 5322196 SGTC_1029 k015-0030 64.7 µM -1.0015324396645 0.147835312163521 no 2885 0.158284732514 920 2208316 SGTC_593 1203-0218 61.7 µM -1.00295795033124 0.147494648379001 no 2886 0.15794057510299 943 3666956 SGTC_3344 9148862 3.898 µM -1.00365715954439 0.147327746096345 no 2887 0.157771946540164 955 4905352 SGTC_602 3130-1533 38.1 µM -1.00386860253206 0.147277299275042 no 2888 0.157720976046667 951 720941 SGTC_2114 5491910 81.25 µM -1.00423550470155 0.147189789926596 no 2889 0.157632556200549 930 2849228 SGTC_377 3970-0964 33.1 µM -1.00549017567781 0.146890803467611 no 2890 0.157330438870956 919 16481235 SGTC_3011 9081274 71.4286 µM -1.00555661302046 0.146874982899981 no 2891 0.157314451771607 948 6625322 SGTC_3035 9091303 49.47 µM -1.00734425801832 0.146449724323431 no 2892 0.156884684162824 947 25237002 SGTC_282 k297-0036 65.7 µM -1.01421090594098 0.144823925220205 no 2893 0.155241062880303 951 5061378 SGTC_3066 9117245 49.47 µM -1.01557105559334 0.144503333679044 no 2894 0.154916846987774 919 17176980 SGTC_1056 3448-1962 115 µM -1.01593320060504 0.14441805563224 no 2895 0.154830598718395 931 715507 SGTC_1081 sertraline 6 µM -1.01605697983259 0.144388915830646 no 2896 0.154801126796469 932 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_402 epigallocatechin gallate 10 µM -1.01613837609418 0.144369755882503 no 2897 0.15478174830882 925 65064 An antioxidant. SGTC_1214 0358-0031 63.7 µM -1.01659605539642 0.144262054195783 no 2898 0.154672815742424 964 4301366 SGTC_1177 0983-0204 23.6 µM -1.01791491518926 0.143952001371213 no 2899 0.154359196402537 909 766818 SGTC_3104 9120930 49.47 µM -1.01984384116393 0.143499337088746 no 2900 0.15390126357149 937 17014836 SGTC_946 3434-1334 87.4 µM -1.02019439720296 0.143417174814304 no 2901 0.153818137154771 914 4047976 SGTC_3023 9089636 49.47 µM -1.02327974168128 0.142695411069409 no 2902 0.153087799653992 956 17249241 SGTC_3091 9116372 49.47 µM -1.02489830350073 0.142317759868476 no 2903 0.15270558759716 951 17169793 SGTC_1511 0906-3109 28.5 µM -1.0278592337429 0.141628651740475 no 2904 0.152008024084636 936 2882180 SGTC_48 0382-0018 55 µM -1.02913788363059 0.14133176686789 no 2905 0.151707443209461 957 762596 SGTC_12 0849-0099 9.267 µM -1.03042783086099 0.141032686638679 no 2906 0.151404607121805 927 6071388 SGTC_2792 7535235 81.82 µM -1.03151433196434 0.140781109593399 no 2907 0.15114984542147 941 1281891 SGTC_2321 7390090 138.78 µM -1.03266783525628 0.140514351768615 no 2908 0.150879685415155 961 649046 SGTC_1761 st044296 37 µM -1.03354160764593 0.140312512738643 no 2909 0.150675254784364 940 1826700 SGTC_2136 5328288 199.296 µM -1.03451020696396 0.140088999160425 no 2910 0.15044885379713 950 262395 SGTC_2753 fluvastatin 17.09 µM -1.03809059254642 0.13926489138213 no 2911 0.149613940381846 948 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_841 0251-0215 91.2 µM -1.03958250282943 0.138922469680352 no 2912 0.149266954728363 940 3888614 SGTC_1848 st056003 16.4 µM -1.04273337641301 0.1382011696054 no 2913 0.148535897608957 904 146492 SGTC_830 4076-0286 57.8 µM -1.04354335369349 0.138016162367643 no 2914 0.148348356354802 931 6866659 SGTC_1157 4092-0394 27.6 µM -1.04437283517197 0.137826875309714 no 2915 0.148156463340652 949 3659885 SGTC_2512 diallyl trisulfide 49.23 µM -1.04493386333374 0.137698949557349 no 2916 0.148026768765876 968 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_32 0928-0142 34.1 µM -1.04545685555503 0.137579769765205 no 2917 0.14790593552882 918 2244242 SGTC_1180 1193-0155 285 µM -1.04659107629955 0.13732154482543 no 2918 0.147644109694394 965 2921347 SGTC_2723 salbutamol 83.58 µM -1.04767090475917 0.137076010970978 no 2919 0.147395128519784 925 9884233 β2-adrenoceptor agonist SGTC_228 caffeine 993.056 µM -1.04905013596048 0.136762834710193 no 2920 0.147077522047867 932 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3191 9110352 49.47 µM -1.04916194401081 0.136737468374524 no 2921 0.147051795246842 930 17122424 SGTC_802 4112-3352 742 µM -1.04974378735638 0.136605515192172 no 2922 0.14691796300951 914 704594 SGTC_2877 9040724 71.43 µM -1.05070721303912 0.136387216478833 no 2923 0.146696541089348 952 6463895 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.05080091118265 0.136365998537561 no 2924 0.146675018613156 959 6708561 SGTC_3317 9138495 8.753 µM -1.05475646565633 0.135472322930267 no 2925 0.145768359880324 931 17020139 SGTC_573 3702-0553 84.7 µM -1.05538662237638 0.135330323533836 no 2926 0.145624269313581 938 1222756 SGTC_2337 9009472 200 µM -1.05567251726136 0.135265933689153 no 2927 0.145558928664564 922 5742383 SGTC_1185 1319-0113 81.3 µM -1.05591318026837 0.135211747346039 no 2928 0.14550394094712 947 4672763 SGTC_1632 st005650 90 µM -1.06248440863308 0.133737955124319 no 2929 0.144007916196769 951 2759605 SGTC_744 1594-0068 283 µM -1.06256841214535 0.133719186621141 no 2930 0.14398885911286 959 668392 SGTC_1147 3809-1045 12.3 µM -1.06278811516444 0.133670107987328 no 2931 0.143939025204546 939 325925 SGTC_1084 voriconazole 435 nM -1.0628255280592 0.133661751695255 no 2932 0.143930540223018 936 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_723 4182-0001 115 µM -1.0632852494061 0.133559100755002 no 2933 0.143826306196459 947 744821 YLR208W SEC13 SGTC_1131 3454-3128 32.3 µM -1.06453478482762 0.133280366626085 no 2934 0.143543252587247 917 710982 SGTC_2802 7925815 54.55 µM -1.0653881424528 0.133090238125942 no 2935 0.14335016020734 956 1262923 SGTC_1679 SEC14.276 6.7 µM -1.0669969073051 0.132732312418279 no 2936 0.142986616248232 934 1005053 YMR079W SEC14 SGTC_2869 9037858 32.47 µM -1.06703532543959 0.132723773080549 no 2937 0.142977942254082 940 27187042 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.07336166901373 0.131322752822263 no 2938 0.141554437834801 953 616764 SGTC_754 3474-0146 171 µM -1.07371722992316 0.131244315210308 no 2939 0.141474718307812 934 24762078 SGTC_905 2-aminofluorene 215 µM -1.07778380908187 0.130349518773494 no 2940 0.14056512334146 946 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1065 prochlorperazine maleate 2.48 µM -1.08435434228677 0.128912695397776 no 2941 0.139103859678721 950 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_831 k061-1017 217 µM -1.08535801884823 0.128694185473384 no 2942 0.138881559170676 978 1240153 SGTC_3161 9100388 49.47 µM -1.08638999787147 0.128469781932457 no 2943 0.138653242422041 956 25236368 SGTC_848 0368-0089 85.6 µM -1.0866958345239 0.128403330046178 no 2944 0.138585627759773 937 762535 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.0888027715467 0.127946185285969 no 2945 0.138120434583855 985 4620898 SGTC_562 3772-2733 112 µM -1.08897011614715 0.127909924854151 no 2946 0.138083532065924 949 2876874 YIL048W NEO1 SGTC_2122 5258151 111.688 µM -1.08939001262602 0.127818972611981 no 2947 0.13799096688418 957 2173356 SGTC_362 0310-0100 9.03 µM -1.08951308144112 0.127792323644649 no 2948 0.137963844678192 957 790235 SGTC_1769 st044406 64.4 µM -1.08973841434553 0.127743540713484 no 2949 0.137914194686866 966 670903 SGTC_1384 3089-0840 101 µM -1.09224341009479 0.127202099067856 no 2950 0.137363063291461 939 1069836 SGTC_2850 9015429 58.44 µM -1.09528184818578 0.126547502199878 no 2951 0.136696588661468 961 6457570 SGTC_336 4111-0029 111 µM -1.09534115643188 0.126534748304779 no 2952 0.136683601566405 959 3131175 SGTC_1828 st055811 49 µM -1.09635061258983 0.126317807905704 no 2953 0.136462684054758 962 5877589 SGTC_1175 0741-0056 27.6 µM -1.09684105671203 0.126212501052555 no 2954 0.136355439518884 949 765927 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.09875503275315 0.125802122640959 no 2955 0.135937465498319 928 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_840 0245-0196 390 µM -1.09984944832857 0.12556788608051 no 2956 0.135698861671573 949 3827528 SGTC_580 1123-0028 41 µM -1.10603651679464 0.12424939860447 no 2957 0.134355357057686 989 1677248 YPR107C YTH1 SGTC_2586 curcumin 80 µM -1.10657137846474 0.124135874033569 no 2958 0.134239643777352 973 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2922 7999257 32.47 µM -1.10715843691669 0.124011354237035 no 2959 0.134112716931907 976 2988377 SGTC_798 1287-0182 476 µM -1.10763723256123 0.12390986258193 no 2960 0.134009258452837 978 1649755 SGTC_2091 4-phenylthiadiazole 200 µM -1.10852049436413 0.123722787675394 no 2961 0.13381854658579 957 270010 SGTC_2303 7774051 200 µM -1.10883002833086 0.123657275177707 no 2962 0.133751756885368 951 2953184 SGTC_689 0833-0039 98 µM -1.11076120462187 0.123249092522792 no 2963 0.133335574778624 972 5374726 SGTC_980 1473-0395 201 µM -1.11224240839923 0.122936658672231 no 2964 0.133016969248592 953 768876 SGTC_1953 st076800 12.1 µM -1.11358334653198 0.12265429067783 no 2965 0.132728987042069 934 297591 SGTC_3115 9123671 49.47 µM -1.11436286220281 0.122490353463565 no 2966 0.132561774413711 978 3286988 SGTC_2082 5219693 150 µM -1.11826426257716 0.121672174201402 no 2967 0.131727072663112 944 2834649 SGTC_3206 9114350 49.47 µM -1.11851902533061 0.121618880719819 no 2968 0.131672692781275 941 17087243 SGTC_363 0455-0021 3.06 µM -1.12021055503731 0.121265447938702 no 2969 0.131312023550306 928 4597466 SGTC_3079 9117512 49.47 µM -1.12127104632206 0.121044234747176 no 2970 0.131086253035186 1011 7185044 SGTC_931 2812-0076 566 µM -1.12235855288799 0.120817681302623 no 2971 0.13085500981501 970 3450959 SGTC_2942 9052777 62.25 µM -1.12245751476432 0.120797080017858 no 2972 0.130833980944956 974 6469503 SGTC_3335 9143315 29.6265 µM -1.12397995038338 0.120480460145851 no 2973 0.130510765845614 934 4899691 SGTC_1364 1653-0028 37.6 µM -1.12510812680118 0.120246211406959 no 2974 0.130271608986234 945 5718652 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.12667885253115 0.119920608664343 no 2975 0.129939143365255 955 165521 SGTC_2612 dictamnine 15.46 µM -1.13010815961645 0.11921189336736 no 2976 0.129215325964097 926 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_469 w7 172 µM -1.13070457897961 0.119088937205701 no 2977 0.12908972671944 951 45115570 A P450 inhibitor. SGTC_1217 1183-1422 255 µM -1.13147464340078 0.118930315327647 no 2978 0.128927685005647 945 2849664 SGTC_928 2764-0428 58.7 µM -1.13379695551764 0.118452857049409 no 2979 0.128439864182025 967 662578 SGTC_2680 butyl paraben 22.24 µM -1.1350410875332 0.118197626432233 no 2980 0.128179051718993 985 7184 An antifungal and steroid mimetic. SGTC_1383 3049-0032 20.7 µM -1.13837763319411 0.117515062971151 no 2981 0.12748141477155 958 712864 SGTC_669 0108-0021 26.2 µM -1.13869020458117 0.117451262905814 no 2982 0.127416194873482 960 17201 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.13974522495971 0.117236100029438 no 2983 0.127196229895728 974 94937 An inhibitor of serotonin biosynthesis. SGTC_2463 5473429 200 µM -1.14517083944474 0.116133999839185 no 2984 0.126069197673701 946 5399405 SGTC_1141 3253-0389 52.6 µM -1.14703701358336 0.115756630541361 no 2985 0.125683161875724 971 5402031 SGTC_2457 5731572 11.68 µM -1.14967731399527 0.115224209910367 no 2986 0.125138400719245 960 2865357 SGTC_2270 7924575 90.91 µM -1.15261515325206 0.114633838968316 no 2987 0.124534190367617 958 1262135 SGTC_999 SEC7.066 22.7 µM -1.15325206943178 0.114506132462435 no 2988 0.124403468544573 972 740511 YDR170C SEC7 SGTC_3163 9099914 49.47 µM -1.1533527794198 0.114485948624893 no 2989 0.124382807434217 994 16268368 SGTC_1692 fluoroquinolonic acid 71 µM -1.15598322852285 0.113959662662771 no 2990 0.123844008570624 961 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1176 0848-0131 83.3 µM -1.1562211773281 0.113912140315014 no 2991 0.123795349858882 968 6769040 SGTC_424 splitomicin 100 mM -1.15631792456067 0.113892822316421 no 2992 0.12377556961695 980 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2176 5809774 33.9695 µM -1.15705784295901 0.113745156346116 no 2993 0.123624364402254 923 2870539 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.15817859354287 0.113521747437589 no 2994 0.12339558106756 977 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_560 2332-1943 155 µM -1.15906433208456 0.113345406995376 no 2995 0.123214981645959 949 21177716 SGTC_1162 k048-0130 20.1 µM -1.17010848645225 0.111163033116975 no 2996 0.120978656862971 956 6797406 SGTC_76 0433-0009 400.328 µM -1.171869602754 0.110817829107014 no 2997 0.120624706391302 1009 2841569 SGTC_1773 st048542 73.5835 µM -1.17258124586785 0.110678554978716 no 2998 0.120481886863032 974 3237138 SGTC_1006 4099-6547 255 µM -1.17288596685196 0.110618957068907 no 2999 0.120420768890998 980 3146833 SGTC_2067 5224629 34.075 µM -1.17590182349202 0.110030350152586 no 3000 0.119817055060645 968 2835000 SGTC_2602 kawain 100 µM -1.17684972613375 0.109845812284376 no 3001 0.119627745550059 961 5369129 SGTC_309 k408-0051 1.48 µM -1.17865343841284 0.109495278933214 no 3002 0.119268101669251 947 3640463 SGTC_1072 oxiconazole 14.9 nM -1.17891057569865 0.109445372384199 no 3003 0.119216893038555 953 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2423 st077119 87.2 µM -1.18113865388369 0.109013619297817 no 3004 0.118773823293955 952 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_553 k007-0256 45.7 µM -1.1817982649239 0.108886036200209 no 3005 0.118642878221377 979 6287000 SGTC_1250 0485-0349 40.2 µM -1.18302705436332 0.108648647968855 no 3006 0.118399212714549 975 6842794 YDL195W SEC31 SGTC_1070 indatraline 8.81 µM -1.18380184159592 0.108499159307171 no 3007 0.118245756534841 967 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1377 2944-0135 198 µM -1.18723144859711 0.107839222715046 no 3008 0.117568169665961 939 1894137 SGTC_1404 3909-7820 48.3 µM -1.18738466735034 0.10780980745753 no 3009 0.117537962538208 929 23741373 SGTC_1646 st011709 75.6 µM -1.19197848089889 0.106930560154936 no 3010 0.116634841572132 979 5757843 SGTC_1789 tunicamycin 25 nM -1.1959985400469 0.106165382655817 no 3011 0.115848564399851 947 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_993 3909-8757 62.7 µM -1.19634964434917 0.106098741806115 no 3012 0.115780071603541 977 4288324 YLR208W SEC13 SGTC_1994 st072947 40.9 µM -1.19638614214201 0.106091816129228 no 3013 0.115772953330204 986 5286565 YDL195W SEC31 SGTC_2318 6029776 164 µM -1.19872469775733 0.105648741749806 no 3014 0.115317505656651 986 818325 SGTC_440 fluspirilene 35.1 µM -1.19886043299001 0.105623065821079 no 3015 0.115291109568333 986 3396 An atypical antipsychotic. SGTC_1920 st075728 45.7 µM -1.19936864627167 0.105526971326107 no 3016 0.115192316757508 961 3400306 SGTC_3102 9121669 49.47 µM -1.20037966512841 0.105335992872744 no 3017 0.114995961342068 997 41905072 SGTC_452 diindolylmethane 8 µM -1.20200130403876 0.105030192482863 no 3018 0.114681511425683 975 3071 Inhibits expression of several cancer promoting factors. SGTC_2098 5376439 882.5 nM -1.20280487119645 0.10487889821452 no 3019 0.114525919666412 973 2844116 SGTC_1895 st058434 18.3 µM -1.20310995918219 0.104821498109523 no 3020 0.114466885969795 998 5393175 SGTC_3052 9092717 49.47 µM -1.2051367922645 0.104440741547561 no 3021 0.114075249205808 977 25237534 SGTC_3013 9080133 71.4286 µM -1.20828163459872 0.103851943548101 no 3022 0.113469475115951 989 17050193 SGTC_2095 5432005 200 µM -1.20913315481458 0.103692931363333 no 3023 0.113305846726461 983 783734 SGTC_983 1491-0821 12.2 µM -1.20933696792447 0.103654897684617 no 3024 0.113266706912973 963 46495113 SGTC_479 n-linoleoylglycine 10 µM -1.21055410707303 0.103427977367541 no 3025 0.113033171011859 991 6433346 An anti-infammatory. SGTC_2473 5854593 8.94 µM -1.21215308081653 0.103130417094583 no 3026 0.112726893974282 967 2872951 SGTC_2837 9008476 45.46 µM -1.21217294718634 0.103126723986099 no 3027 0.112723092381154 970 2992805 SGTC_104 0074-0074 590.992 µM -1.2123541957953 0.103093034758131 no 3028 0.112688413197819 974 3943124 SGTC_1203 3992-3522 103 µM -1.21241177248065 0.103082334478299 no 3029 0.112677398363548 989 5322312 SGTC_2242 6630449 61.2675 µM -1.21440408423392 0.102712572079515 no 3030 0.112296728281672 979 691249 YDR170C SEC7 SGTC_845 0330-0138 4.51 µM -1.21528853672944 0.102548731745045 no 3031 0.112128031230835 969 9039800 SGTC_2449 5812982 45.77 µM -1.21606854202145 0.102404397460966 no 3032 0.111979406428113 987 776185 SGTC_1213 1315-0166 115 µM -1.21682489307649 0.102264581345333 no 3033 0.111835423347515 960 768401 SGTC_1189 1431-2119 7.28 µM -1.21875706833293 0.101908037458188 no 3034 0.111468205291869 979 3107275 SGTC_2250 alverine citrate 130 µM -1.22238287539818 0.101241411495699 no 3035 0.110781436019196 945 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1502 4534-4282 27.7 µM -1.22429423201011 0.100891278969687 no 3036 0.110420626031156 1000 3278949 SGTC_1498 4478-3555 97.6 µM -1.22562257646244 0.100648466258408 no 3037 0.110170368970879 976 3437919 SGTC_61 0978-8327 98.565 µM -1.23045578723088 0.0997685839496593 no 3038 0.109263236832852 965 6150059 YHR072W ERG7 SGTC_1323 1348-1351 11.2 µM -1.23134392396198 0.0996075123681294 no 3039 0.109097130197445 973 6989654 SGTC_2841 9004761 38.96 µM -1.23147644191955 0.0995834953460721 no 3040 0.109072361166692 973 2991039 SGTC_1184 1269-1718 139 µM -1.23163237804249 0.0995552395297954 no 3041 0.109043220205369 968 5403821 SGTC_3224 9130643 49.47 µM -1.23243300112789 0.0994102579105959 no 3042 0.108893689839589 982 17644395 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.23771372253759 0.0984578579063767 no 3043 0.10791111455071 954 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1429 4049-0205 9.46 µM -1.23968299057715 0.0981044079425072 no 3044 0.107546335458682 973 22774478 SGTC_3072 9116419 49.47 µM -1.24176504128621 0.0977317273767042 no 3045 0.107161632258957 979 17170162 SGTC_2822 7994718 71.43 µM -1.24486684080495 0.0971784415259346 no 3046 0.106590350730374 1019 1018011 SGTC_2208 7283366 200 µM -1.24826598909826 0.0965747594134224 no 3047 0.105966832503854 961 898663 SGTC_2071 5230951 39.92 µM -1.25054367070793 0.0961717919376785 no 3048 0.105550506448435 994 1799272 SGTC_2290 7904846 200 µM -1.25087446145589 0.0961133713763793 no 3049 0.105490141363159 970 2962154 SGTC_523 1934-0222 13.7 µM -1.25122838824473 0.0960508936831793 no 3050 0.105425581899487 998 1361595 SGTC_955 1216-0110 33 µM -1.25309680555256 0.0957215621548791 no 3051 0.105085239231565 978 3619719 SGTC_1124 fisetin 1.16336 µM -1.2532521218298 0.0956942231962231 no 3052 0.105056983342866 981 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1336 1486-0901 104 µM -1.259977614442 0.0945158978651439 no 3053 0.103838718887381 976 5006114 SGTC_1841 st054148 70 µM -1.26313773659246 0.093965944019663 no 3054 0.103269842144738 1006 675442 SGTC_1662 st014054 52 µM -1.2697209077337 0.0928278696995409 no 3055 0.102092031288622 999 2838777 SGTC_2872 9044037 25.97 µM -1.27035044640971 0.092719573628382 no 3056 0.101979913112693 997 6465195 SGTC_2070 5230947 200 µM -1.27117929261789 0.0925771343114927 no 3057 0.101832435788355 1008 2835538 SGTC_214 4373-3496 70 µM -1.2739559340844 0.0921011409206221 no 3058 0.101339516782968 997 3779166 SGTC_2558 carylophyllene oxide 100 µM -1.27442706146405 0.0920205567409671 no 3059 0.101256053401646 995 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3150 9097574 49.47 µM -1.28002138278924 0.0910676611880941 no 3060 0.100268807897359 975 17217476 SGTC_2059 5238311 157 µM -1.28610613577957 0.0900395597541863 no 3061 0.0992030115209835 987 703021 SGTC_2157 5649910 96.377 µM -1.28678582565201 0.0899252545706235 no 3062 0.099084474363943 989 2858091 SGTC_906 1165-0455 526 µM -1.28877196279949 0.0895918588255872 no 3063 0.098738687967132 993 3252859 SGTC_2952 9073731 13.78 µM -1.290324330567 0.0893319168250107 no 3064 0.0984690363124076 1002 16457353 SGTC_56 0957-0365 83.25 µM -1.29070483750167 0.0892682871274786 no 3065 0.0984030232968975 990 6752360 SGTC_1071 trifluoperazine 6.31 µM -1.2958906600215 0.0884044544930902 no 3066 0.0975065787557768 1015 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2369 9071472 200 µM -1.29697842952526 0.0882240513244606 no 3067 0.0973193043807327 990 17296037 SGTC_2975 9084847 53.72 µM -1.29913701953998 0.0878668687099847 no 3068 0.0969484553004201 993 27211724 SGTC_1574 spiramycin 23.7 µM -1.3012050975019 0.087525675864566 no 3069 0.09659413045555 982 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3031 9088762 49.47 µM -1.30234044174233 0.0873387869214823 no 3070 0.0964000162815553 1004 205253 SGTC_511 blebbistatin 171 µM -1.30582843005413 0.0867664928980371 no 3071 0.0958054547881087 1003 3476986 A myosin inhibitor. SGTC_920 mycophenolic acid 780.421 nM -1.31099617890595 0.0859237491369727 no 3072 0.0949295272861095 998 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_757 1066-0008 322 µM -1.31120478062223 0.0858898599610362 no 3073 0.0948942938329815 963 6842497 SGTC_1178 0988-0033 191 µM -1.31162613647865 0.085821437522678 no 3074 0.0948231549573812 982 5392207 SGTC_77 0828-0286 12.516 µM -1.3149678859029 0.0852802272810844 no 3075 0.0942603478167854 981 745345 SGTC_1936 st074407 74.3 µM -1.31707673544648 0.0849400087103385 no 3076 0.0939064521726535 1002 809813 SGTC_1077 5-fluorocytosine 377 nM -1.31806075608891 0.0847816062333232 no 3077 0.0937416551301264 994 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_702 1488-0190 94 µM -1.31837186076549 0.0847315723491964 no 3078 0.0936895978950383 990 949357 SGTC_2385 9074692 200 µM -1.31905911215233 0.0846211225873961 no 3079 0.0935746755822356 1003 17046906 SGTC_1199 1638-0010 4.46 µM -1.31932165780576 0.0845789567862371 no 3080 0.0935308001375182 981 3111136 SGTC_3307 9126885 69.2785 µM -1.32621721881913 0.0834771392927296 no 3081 0.092383878711556 995 24824909 SGTC_1107 amlodipine 47 µM -1.33137395492291 0.0826602381815327 no 3082 0.0915329974594023 890 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3279 9140807 49.47 µM -1.33141069912054 0.0826544390382297 no 3083 0.0915269554355651 1018 45595718 SGTC_3014 9081533 49.47 µM -1.33157538053855 0.0826284519982604 no 3084 0.0914998797146895 1003 21367265 SGTC_3036 9090181 49.47 µM -1.33208325538901 0.0825483471102637 no 3085 0.0914164160095064 1009 25236586 SGTC_572 0960-0087 17.7 µM -1.33266368084074 0.0824568707281312 no 3086 0.0913210985194138 1007 6796365 SGTC_659 k018-0002 107 µM -1.33677711940225 0.0818107691667238 no 3087 0.090647699981733 1009 6797879 YHR007C ERG11 SGTC_2974 9094440 9.66 µM -1.33764623567018 0.0816747458793654 no 3088 0.090505892430166 975 25236134 SGTC_1612 st002233 45.4 µM -1.33823120012339 0.0815832905492992 no 3089 0.0904105406927556 982 1035021 SGTC_2279 7948423 32.93 µM -1.33882407573473 0.0814906771736651 no 3090 0.0903139755364891 976 1247112 SGTC_2904 7225135 42.03 µM -1.34130407171859 0.0811041351837156 no 3091 0.0899108741822721 1030 4446116 SGTC_420 mitomycin C 81.9 mM -1.34364923689235 0.080739882843973 no 3092 0.0895309198824237 964 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_339 3091-4833 71.4 µM -1.34507758869 0.0805186365769622 no 3093 0.0893000898816869 991 3240077 SGTC_474 dl-dihydrosphingosine 5 µM -1.35490534298715 0.0790087544656697 no 3094 0.087723858570296 977 3058739 A sphingolipid protein kinase C inhibitor. SGTC_635 k038-0028 24.7 µM -1.35603594757187 0.0788364392228673 no 3095 0.0875438653877112 1012 4035102 SGTC_1741 st038134 10.228 µM -1.36051713331878 0.0781562624168149 no 3096 0.0868331674062495 1012 1272587 SGTC_2824 7998404 51.95 µM -1.36283854639563 0.0778056615444738 no 3097 0.0864666999384325 999 837851 SGTC_650 1328-0195 38 µM -1.3635193367479 0.0777030691112544 no 3098 0.0863594472659237 1012 2780821 SGTC_1775 st081588 35.1725 µM -1.36536510694379 0.0774254354363976 no 3099 0.0860691625499854 979 1426443 YGL099W LSG1 SGTC_1616 st002734 56.1 µM -1.36776243032284 0.0770659647974374 no 3100 0.0856932255624881 999 4026101 SGTC_1560 lithocholic acid 53.1 µM -1.3738700977335 0.0761558734689997 no 3101 0.0847410071514731 976 9903 A bile acid which acts as a detergent. SGTC_699 0375-0592 111 µM -1.37503453265522 0.0759832956421005 no 3102 0.0845603694933024 981 762578 SGTC_2821 7996764 71.43 µM -1.37894841595988 0.0754054114387397 no 3103 0.0839553294692802 975 2987135 SGTC_2634 4'-methoxyflavone 100 µM -1.38008318288794 0.0752384912727755 no 3104 0.0837805172869224 1005 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1002 4049-0206 172 µM -1.38595512697867 0.0743792464596051 no 3105 0.0828803029964153 995 4662749 SGTC_2110 5483698 200 µM -1.38889392611275 0.0739520333892202 no 3106 0.0824325038892638 993 2848765 YHR062C RPP1 SGTC_2274 7947094 46.08 µM -1.38980550163648 0.0738198994133772 no 3107 0.0822939735119298 1011 2971028 SGTC_1264 0783-0040 158 µM -1.39400083218921 0.0732141062991145 no 3108 0.0816586766721731 991 2855798 SGTC_223 busulfan 5 mM -1.3941286311998 0.0731957123822366 no 3109 0.081639382327527 1002 2478 A DNA alkylator. SGTC_1259 0671-0132 43 µM -1.40030753161363 0.0723106041507159 no 3110 0.0807106232163671 999 X1259 SGTC_1523 st012844 44.7 µM -1.40066575868607 0.0722595418773907 no 3111 0.0806570233209875 1011 4274103 SGTC_3195 9113082 49.47 µM -1.40260172305351 0.0719840644270301 no 3112 0.0803678188621293 1028 17018038 SGTC_2807 7945238 51.95 µM -1.40289916406104 0.0719418116072307 no 3113 0.0803234550995436 1022 17148797 SGTC_2161 5662504 8.5105 µM -1.40291203549104 0.07193998359265 no 3114 0.0803215357246968 959 2859334 SGTC_2871 9038510 12.99 µM -1.40315608773892 0.0719053297647892 no 3115 0.080285149454423 1016 4945164 SGTC_2940 9060638 45.86 µM -1.40789045576912 0.0712356103516785 no 3116 0.0795817548332761 991 4027022 SGTC_1554 st069299 38.7 µM -1.40967372656455 0.0709845957917504 no 3117 0.0793180230564786 996 24207999 SGTC_170 4197-0004 226 µM -1.41019998424745 0.070910649334181 no 3118 0.0792403202408187 1005 218692 SGTC_1900 st060200 72.8 µM -1.41105115942321 0.0707911727637504 no 3119 0.0791147648278068 994 688945 SGTC_52 0329-0193 875 nM -1.41198849977489 0.0706597804929589 no 3120 0.0789766736963257 1010 3739292 SGTC_2511 berberine 10.47 µM -1.41464634918528 0.0702882338932016 no 3121 0.0785861060158844 1002 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_430 0958-0115 16.4 µM -1.41576533960652 0.0701322579217232 no 3122 0.0784221103702801 997 6833180 SGTC_2123 5259487 200 µM -1.41891555082375 0.0696945800404122 no 3123 0.0779618190022222 1014 2173474 SGTC_1463 k081-0032 34.1 µM -1.4192162883648 0.0696529069505725 no 3124 0.0779179843190938 941 977755 SGTC_765 1319-0117 244 µM -1.42290339825345 0.0691435436085974 no 3125 0.0773820804977123 988 3487746 YGL099W LSG1 SGTC_1382 3002-2117 298 µM -1.42408347633214 0.0689811270768161 no 3126 0.0772111545126349 1040 1497314 SGTC_201 4262-0159 12.803 µM -1.42850110401068 0.0683757299462609 no 3127 0.0765738385393485 1040 1341029 SGTC_2468 5987765 72.9 µM -1.43386347277003 0.0676463823413729 no 3128 0.0758056137071062 1017 26772094 SGTC_1075 aripiprazole 15.2 µM -1.43704755401972 0.0672161611747631 no 3129 0.0753522409211639 1029 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1292 0kpi-0043 232 µM -1.43842184196211 0.0670311273881389 no 3130 0.0751571994837099 1016 3333905 SGTC_2388 9080168 200 µM -1.43883981776244 0.0669749294292966 no 3131 0.0750979560068263 1013 15943073 SGTC_1288 0973-0013 65.5 µM -1.44274833380452 0.0664511813627271 no 3132 0.0745456891204347 1023 4315430 SGTC_2251 lansoprazole 556 µM -1.44281268959546 0.0664425841849711 no 3133 0.0745366217655723 1025 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3227 9130768 49.47 µM -1.45055163951122 0.0654150157174664 no 3134 0.0734523749572685 1049 17720899 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.45179798145921 0.0652506865476717 no 3135 0.0732788926755759 1011 165506 SGTC_1370 2001-0092 44.6 µM -1.45816537476784 0.0644161440751152 no 3136 0.0723974826182312 1014 790957 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.46145646540186 0.063988060595093 no 3137 0.0719451072460692 1017 688803 SGTC_1951 sophoraflavanone G 9.2 µM -1.46460625254234 0.0635804317936664 no 3138 0.0715141875664009 1001 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1701 st028638 40.4 µM -1.46527938484364 0.0634935811914175 no 3139 0.0714223542962308 1027 3490878 SGTC_3182 9108849 49.47 µM -1.46602871882758 0.0633970073319318 no 3140 0.0713202315601905 1011 17133045 SGTC_1675 st018485 24.5 µM -1.47286550195626 0.0625211581512386 no 3141 0.0703936529239898 1028 3323024 SGTC_1277 0873-0036 22 µM -1.4730081623281 0.0625029831498262 no 3142 0.0703744174381243 1024 5965735 SGTC_898 1000-0849 28.3 µM -1.47314117487757 0.0624860409967099 no 3143 0.0703564864488792 1023 6751807 SGTC_2267 7931562 200 µM -1.47559849085572 0.0621736899534687 no 3144 0.0700258552578818 1027 934880 SGTC_126 0417-1624 672.48 µM -1.48037398567387 0.0615701585655416 no 3145 0.0693867342504766 1012 41912 YDL195W SEC31 SGTC_2624 nerol 100 µM -1.48072741101934 0.0615256748115384 no 3146 0.0693396132597817 1022 637566 A natural product oil. SGTC_390 dec-rvkr-cmk 16.7 µM -1.48467489016737 0.061030530950651 no 3147 0.0688149832044494 1020 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_914 3820-6779 408 µM -1.48556691143267 0.0609190747404279 no 3148 0.0686968563087316 1006 2893481 SGTC_2623 humulene 100 µM -1.48651927215759 0.0608002549550093 no 3149 0.0685709115544297 1023 6187145 An anti-inflammatory. SGTC_294 k038-0071 157 µM -1.48823907795323 0.0605861453119234 no 3150 0.0683439274785015 1029 24152826 SGTC_360 0957-0399 1.01 µM -1.49513624292911 0.059733394145109 no 3151 0.0674394444058384 1021 6752301 YPR165W RHO1 SGTC_2806 7952793 58.44 µM -1.49535369128602 0.059706662983514 no 3152 0.0674110797432245 1007 2972490 SGTC_2893 9048488 25.97 µM -1.49579912738103 0.0596519343086122 no 3153 0.0673530044185046 1044 6467338 SGTC_947 3447-0010 211 µM -1.49593133889686 0.0596356976581724 no 3154 0.0673357743142273 1015 748350 SGTC_726 3448-4391 34.2 µM -1.49714824460156 0.0594864143190934 no 3155 0.0671773443741174 1020 1356692 SGTC_1252 0493-0875 34.8 µM -1.49761018411164 0.0594298228642558 no 3156 0.0671172796224959 1014 3960963 SGTC_2183 6420625 130.508 µM -1.50223840711618 0.058865153894238 no 3157 0.0665177745659452 1015 2897619 SGTC_3274 9138298 49.47 µM -1.5033228269379 0.0587334593628648 no 3158 0.0663779082425694 1030 17015756 SGTC_2865 9030313 51.95 µM -1.50568121890568 0.0584478490116962 no 3159 0.0660745137582058 1022 42562754 SGTC_1857 st056007 79.3 µM -1.50817006614016 0.0581476240393947 no 3160 0.0657555031767426 1022 619834 SGTC_3202 9113761 49.47 µM -1.50982125142406 0.0579491141647121 no 3161 0.0655445204374902 1014 4798415 SGTC_399 oxolinic acid 75 µM -1.51284369395817 0.0575871283765424 no 3162 0.0651596835392175 1027 4628 A DNA gyrase inhibitor. SGTC_1136 pergolide 1.05886 µM -1.51475244696106 0.0573594424621428 no 3163 0.0649175535339998 1017 47811 A dopamine receptor agonist. SGTC_2448 5185112 27.17 µM -1.52078907353749 0.0566440224549666 no 3164 0.0641563886309897 998 5718189 SGTC_1268 0828-0275 2.46 µM -1.52140502482698 0.0565714210935844 no 3165 0.0640791143443942 1023 745337 SGTC_648 0375-0473 33.3 µM -1.52314919626326 0.0563662356472788 no 3166 0.0638606915226914 1027 1713139 SGTC_99 0109-0120 622.8 µM -1.5240053400361 0.0562657332138637 no 3167 0.0637536886178547 1007 759414 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.52413417049796 0.0562506220850913 no 3168 0.0637375991570534 1045 61125 An anti-inflammatory. SGTC_249 wiskostatin 11.211 µM -1.52963321180522 0.0556085916505785 no 3169 0.0630537719329351 1003 2775510 A n-wasp and actin depolymerizer. SGTC_2517 totarol 10 µM -1.53409583843044 0.0550918291984481 no 3170 0.0625030384893625 1016 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1238 0333-0287 48.8 µM -1.5360806139895 0.054863218832653 no 3171 0.0622593051206642 1016 7226 SGTC_2093 5331342 194.4 µM -1.53614836487055 0.054855428406412 no 3172 0.062250998315577 1027 33839 SGTC_1413 3910-0535 34.4 µM -1.53891373967798 0.0545381935789419 no 3173 0.0619126782144551 1026 2876951 SGTC_2635 hydroquinidine 100 µM -1.54109573741484 0.0542889073674516 no 3174 0.0616467435727468 1027 442912 An experimental heart treatment. SGTC_1308 1187-1617 41.4 µM -1.54342806393365 0.0540234443127933 no 3175 0.0613634744389811 1028 2882570 SGTC_100 0086-0128 49.5915 µM -1.54387654255585 0.0539725169095184 no 3176 0.0613091219027645 1027 93297 SGTC_2864 9034755 47.6 µM -1.54709455335412 0.0536082066473517 no 3177 0.0609202235678672 1015 4930451 SGTC_21 0849-0113 22.993 µM -1.55130419915363 0.0531345776683539 no 3178 0.0604144005015388 1034 1560156 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.55581919474788 0.0526302874668739 no 3179 0.0598755462201803 1034 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1011 4112-3381 17.4 µM -1.55643493033671 0.0525618098356774 no 3180 0.0598023522235521 1018 2877139 SGTC_3002 9075603 71.4286 µM -1.5574955686689 0.052444019195305 no 3181 0.0596764359304777 1013 20105405 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.55957604342617 0.052213577951245 no 3182 0.0594300507241763 1046 6708784 An antioxidant flavonoid SGTC_476 mead acid 10 µM -1.55968928476494 0.0522010580264513 no 3183 0.0594166627650996 1050 5312531 An omega 9 fatty acid. SGTC_1676 st018489 23.4 µM -1.56006692157641 0.0521593238583514 no 3184 0.0593720337350856 1013 3696235 SGTC_3313 9133968 57.047 µM -1.5623369388953 0.0519090132557313 no 3185 0.0591043171823333 1004 1494643 SGTC_509 pifithrin 175 µM -1.56701508756939 0.0513961734759288 no 3186 0.05855558252627 1048 4817 A p53 inhibitor. SGTC_2148 5546263 113.568 µM -1.5675233259952 0.051340701622057 no 3187 0.058496209158082 1038 792097 SGTC_2885 9057732 51.95 µM -1.58298789362587 0.0496754724358019 no 3188 0.0567121118844909 1034 6471414 SGTC_2832 7992762 51.95 µM -1.58310005994011 0.0496635536736051 no 3189 0.0566993299849754 1011 2985177 SGTC_979 1426-2828 121 µM -1.59330810756365 0.0485883683862156 no 3190 0.0555455443843413 1043 747872 SGTC_321 4534-3890 65.3 µM -1.59411832572877 0.0485038337532756 no 3191 0.0554547675475627 1025 699746 SGTC_710 3448-4187 58 µM -1.59611161683437 0.0482963629742633 no 3192 0.0552319377567241 1025 3946412 SGTC_2809 7964133 12.99 µM -1.59627604547237 0.0482792802396107 no 3193 0.055213587918474 1047 1253665 SGTC_647 0140-0236 81 µM -1.59711547317529 0.0481921461647985 no 3194 0.0551199848475507 1050 990837 SGTC_634 1611-4317 11.2 µM -1.59904539682239 0.0479922938462667 no 3195 0.0549052579687082 1046 2843522 SGTC_3322 9139058 2.11 µM -1.59923473595332 0.0479727227079534 no 3196 0.0548842274060608 1041 4908926 YPR165W RHO1 SGTC_729 4092-0585 94.1 µM -1.60797336759895 0.0470763794706774 no 3197 0.0539205058758411 1011 2169061 SGTC_652 0437-0092 114 µM -1.61248381618254 0.0466190133288547 no 3198 0.0534283494278409 1034 3091274 SGTC_642 0335-0876 158 µM -1.6162056285043 0.0462443070281959 no 3199 0.0530249311377217 1044 6812350 SGTC_1234 0326-0494 15.5 µM -1.61686753459316 0.0461779213440442 no 3200 0.0529534388254929 1037 1547813 SGTC_1109 tnp00067 928.257 nM -1.62231761763872 0.0456342119485015 no 3201 0.052367679179781 1039 676295 SGTC_1116 jasmonic acid  1.58368 µM -1.62398603346996 0.0454688007563059 no 3202 0.0521893946808177 1033 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1806 st050005 60.3 µM -1.62518819949059 0.0453499139518966 no 3203 0.0520612320331908 1037 5194765 SGTC_537 1334-0398 209 µM -1.6261224738098 0.0452576927575881 no 3204 0.0519618020223018 1024 5846986 SGTC_6 0844-0013 19.835 µM -1.62790058118707 0.0450825945707287 no 3205 0.0517729840890025 1057 1584900 SGTC_2216 7189485 200 µM -1.63645527879006 0.0442477823629953 no 3206 0.0508721690237739 1029 731273 SGTC_869 0564-0080 44.1 µM -1.64396317234668 0.043525430381887 no 3207 0.050091904882366 1037 6843321 SGTC_1719 st032227 49.2 µM -1.64432105522246 0.0434912367179572 no 3208 0.0500549511888969 1014 3125804 SGTC_2232 chlorophetanol 41.5365 µM -1.64447806272714 0.0434762423926011 no 3209 0.0500387460222777 1056 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2987 9018338 71.43 µM -1.64479374388249 0.0434461072536198 no 3210 0.0500061763828421 1034 5055682 SGTC_590 k048-0076 22.4 µM -1.645129224321 0.0434141005453934 no 3211 0.0499715825307206 1054 6832814 SGTC_952 1185-0122 232 µM -1.65097866762487 0.0428590843801369 no 3212 0.0493714654426892 1028 678600 SGTC_2497 7-hydroxyflavone 100 µM -1.65196466987682 0.042766096184063 no 3213 0.0492708766507876 1036 5281894 SGTC_1782 st039423 80.636 µM -1.65196692608734 0.0427658835918408 no 3214 0.0492706466672131 1052 2068169 SGTC_2268 7933382 153.85 µM -1.656436081578 0.0423464496141319 no 3215 0.0488167696175229 1019 935025 YOR257W CDC31 SGTC_773 4358-1457 44.6 µM -1.65949760517328 0.0420610483914417 no 3216 0.0485077814136773 1059 1186886 SGTC_3046 9092212 49.47 µM -1.66008104755658 0.0420068357736402 no 3217 0.04844907453572 1050 25236637 SGTC_2203 7227154 166.4 µM -1.66581351687468 0.041477185683467 no 3218 0.0478752815296224 1048 896304 SGTC_486 niguldipine 82 µM -1.68009655304877 0.0401810227516004 no 3219 0.0464692657258054 1040 1236 A calcium channel blocker. SGTC_297 0986-0032 24 µM -1.68757240031346 0.0395158338073922 no 3220 0.0457466705038109 1030 2847425 SGTC_3177 9107506 49.47 µM -1.68849665971673 0.0394342204454251 no 3221 0.0456579648154965 1054 8897194 SGTC_2080 5212524 12.4 µM -1.69117460232331 0.0391985284519218 no 3222 0.045401730098961 1026 260183 SGTC_821 1114-0266 29.2 µM -1.70621780405604 0.0378957665098177 no 3223 0.043983767534784 1044 3123235 SGTC_1985 st071382 65.5 µM -1.71019946458313 0.0375569264304456 no 3224 0.0436144973464916 1054 6123237 SGTC_114 0364-0001 490.298 µM -1.7175080266219 0.0369414059259413 no 3225 0.0429431945681473 1050 4003655 SGTC_3180 9109287 49.47 µM -1.71827111010774 0.0368776179623253 no 3226 0.0428735881573153 1022 18891271 SGTC_1984 st072354 53.1 µM -1.72075268896196 0.0366707992792727 no 3227 0.0426478554351935 1032 5762938 SGTC_2655 perillic acid 100 µM -1.72089768116277 0.036658744796591 no 3228 0.0426346962269106 1066 5702197 An apoptosis inducer. SGTC_331 k048-0133 24.5 µM -1.72451116831644 0.036359369196266 no 3229 0.0423078022706745 1050 6813582 SGTC_1965 Pectolinarigenin 58.4 µM -1.75145464600012 0.0341896680189811 no 3230 0.0399338135578764 1060 5320438 An anti-inflammatory. SGTC_458 nppb 133 µM -1.7623887239072 0.033340074589373 no 3231 0.0390018212485053 1057 4549 A chloride channel blocker. SGTC_2217 6934799 96.0675 µM -1.76819521773335 0.0328960168424411 no 3232 0.0385141367077158 1051 675606 SGTC_2380 9035439 200 µM -1.76891974117793 0.032840951823886 no 3233 0.0384536346210264 1044 6462575 SGTC_1661 st013063 9.66 µM -1.77240850262644 0.0325768628231358 no 3234 0.0381633857009877 1046 721395 SGTC_929 2805-0021 398 µM -1.77389409816218 0.0324649405641079 no 3235 0.0380403345781406 1067 3098024 SGTC_2334 9017922 200 µM -1.77730168839687 0.0322094164799585 no 3236 0.0377593080099888 1041 3163164 SGTC_804 1595-0054 20.9 µM -1.78575675171549 0.0315825619767692 no 3237 0.0370693260093811 1056 761523 Stimulates phospholipase C. SGTC_939 1165-0479 45.3 µM -1.79106774306307 0.0311939884149014 no 3238 0.036641212376169 1036 1377347 SGTC_1385 3091-4834 14.1 µM -1.79532414241232 0.0308854351370118 no 3239 0.0363010353479273 1057 4072814 SGTC_2178 5812956 200 µM -1.79629685144874 0.0308152776435091 no 3240 0.0362236591754604 1045 5403383 SGTC_3310 9130229 44.1445 µM -1.79997142643125 0.0305514352157957 no 3241 0.0359325750587156 1057 7761258 SGTC_783 0848-0141 92.7 µM -1.80140472866923 0.0304490295565794 no 3242 0.0358195556908823 1050 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_101 0490-5701 117.494 µM -1.8031299398842 0.0303261450831559 no 3243 0.0356839050533497 1039 4661669 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.81095119593096 0.0297741913258131 no 3244 0.035074203320962 1058 688751 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.81220048215366 0.0296868047062463 no 3245 0.0349776123034729 1056 16486 A toxic proline analog. SGTC_1054 3429-0080 167 µM -1.81416597267213 0.0295497510295722 no 3246 0.0348260885732513 1059 1162877 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.81783164424953 0.0292955468261802 no 3247 0.0345449342376844 1053 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1266 0828-0227 32.9 µM -1.81926612728493 0.0291965650444492 no 3248 0.0344354192461524 1064 3913820 SGTC_1587 estradiol valerate 56.1 µM -1.81937717084265 0.0291889144477686 no 3249 0.0344269535828319 1058 13791 A steroid. SGTC_313 3474-0040 5.03 µM -1.82407030681032 0.0288670895430445 no 3250 0.034070721943255 1064 1043375 YIL048W NEO1 SGTC_1899 st063254 59.6 µM -1.82460466096937 0.0288306347449221 no 3251 0.0340303547783245 1043 3093813 SGTC_1757 st041620 31.8375 µM -1.8284892002961 0.0285667718604589 no 3252 0.033738082517148 1060 5289815 SGTC_1510 1123-0200 71.5 µM -1.83022506960296 0.0284495114992058 no 3253 0.0336081452717586 1054 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2587 piperic acid 92.2 µM -1.83115011736964 0.0283871869940623 no 3254 0.0335390698902435 1042 5370536 SGTC_429 1112-0049 25.5 µM -1.84908858732828 0.0272008840492013 no 3255 0.0322225110299728 1053 2836170 SGTC_3113 9123498 49.47 µM -1.85552604990909 0.0267853748277888 no 3256 0.0317605714074153 1073 8897275 SGTC_997 3996-0078 137 µM -1.86064003849269 0.026459079542219 no 3257 0.0313975133485874 1046 735687 SGTC_796 1234-0020 70.7 µM -1.86282457508856 0.026320712336861 no 3258 0.0312434756502523 1041 46495034 SGTC_2368 9071271 200 µM -1.8693010776385 0.0259140449448609 no 3259 0.0307904691464052 1057 27209959 SGTC_776 4476-4378 112 µM -1.88996997682618 0.0246512212049092 no 3260 0.0293809877797501 1064 2892008 SGTC_2300 7976697 71.57 µM -1.89030752996596 0.0246310337941795 no 3261 0.0293584211518228 1045 2236109 SGTC_1387 3342-1166 1.8 µM -1.89203086247257 0.0245281857305851 no 3262 0.0292434344459731 1047 3418228 SGTC_2515 chrysin 20.77 µM -1.90286095500545 0.0238900659308513 no 3263 0.0285293454702399 1037 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_962 1254-0300 21.5 µM -1.90589007567871 0.0237141046455238 no 3264 0.0283322344609772 1057 7340576 SGTC_3192 9110362 49.47 µM -1.90832239285368 0.023573601634001 no 3265 0.028174780252781 1070 16649480 SGTC_2351 9026858 72.31 µM -1.92263795942048 0.0227607769843223 no 3266 0.0272627666546499 1068 1409300 SGTC_2128 5255449 168.493 µM -1.92349617422044 0.0227128081015866 no 3267 0.0272088832523404 1044 736008 SGTC_3130 9127414 49.47 µM -1.93403031178749 0.0221309242188931 no 3268 0.026554700546504 1066 1494646 SGTC_770 0389-1121 67.2 µM -1.93753816853732 0.0219399713896028 no 3269 0.0263397961889662 1073 6753108 SGTC_1155 4088-0394 48.2 µM -1.95404545429353 0.0210599594723095 no 3270 0.0253479209466147 1054 2326248 SGTC_409 arachidonic acid 100 µM -1.9616310965494 0.0206656909185807 no 3271 0.0249027245766088 1054 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_273 hydroxyurea 18.1 mM -1.9625241636888 0.0206196871752062 no 3272 0.0248507450973868 1073 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_496 calpeptin 138 µM -1.96774678021835 0.0203523928341545 no 3273 0.0245485901931705 1052 73364 A calpain inhibitor. SGTC_1362 1611-0397 101 µM -1.98034949208737 0.0197194544454066 no 3274 0.0238321355706516 1068 27816 SGTC_1226 3909-7979 35.4 µM -1.98917666775388 0.0192861510219855 no 3275 0.0233408531517653 1054 6615510 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.98981841376072 0.0192549673363839 no 3276 0.0233054711281867 1045 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.99228394710224 0.0191355605629093 no 3277 0.023169956004928 1054 5282309 SGTC_1322 1348-1070 12 µM -2.0057906777336 0.0184925378590946 no 3278 0.0224392928461781 1065 6758089 SGTC_3350 9150499 3.57 µM -2.01128077320816 0.0182364772996736 no 3279 0.0221479040857325 1067 4910996 YPR165W RHO1 SGTC_330 1488-0319 80.1 µM -2.01466726770612 0.0180800411056703 no 3280 0.0219697620268412 1055 6846614 SGTC_599 1935-0052 86.5 µM -2.02511121144054 0.0176047769747725 no 3281 0.0214279729671596 1064 9557311 SGTC_3003 9075612 71.4286 µM -2.02782615405508 0.0174829908947454 no 3282 0.0212889970228673 1075 6501993 SGTC_2260 7964312 200 µM -2.02933927220744 0.0174154285831277 no 3283 0.0212118729351022 1072 231951 SGTC_880 0833-0487 87.2 µM -2.03216803171747 0.017289719421471 no 3284 0.0210683240170096 1072 76075 SGTC_2167 5876490 200 µM -2.03494385940926 0.0171671168498901 no 3285 0.0209282610857574 1061 686534 SGTC_2533 agelasine 13.65 µM -2.03966243101595 0.0169604118998827 no 3286 0.0206919796204595 1060 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_892 0929-0076 29 µM -2.04500855658931 0.0167287907075938 no 3287 0.0204270072669307 1064 5751038 SGTC_1623 st003709 20.3 µM -2.04702305583294 0.0166422170978731 no 3288 0.0203279104228437 1068 16192618 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.05079692036225 0.0164810658674605 no 3289 0.0201433638010142 1076 279621 SGTC_3028 9087778 49.47 µM -2.0803703954376 0.0152638560926805 no 3290 0.0187457862437126 1073 17217395 SGTC_510 ag-490 170 µM -2.08389203956198 0.0151241881415942 no 3291 0.0185849943043443 1084 5328779 SGTC_2774 tamoxifen 10.92 µM -2.09249001623708 0.0147877989741633 no 3292 0.0181973519615244 1062 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_441 propafenone 146 µM -2.12037230438418 0.0137408303489117 no 3293 0.0169873302152277 1071 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1352 1496-0991 99 µM -2.13244151288612 0.0133078532503468 no 3294 0.0164852838851918 1072 3000039 SGTC_1717 st033143 58.0435 µM -2.13648837426368 0.0131653364970374 no 3295 0.0163198137896717 1064 674616 SGTC_20 0481-0013 4.944 µM -2.15416388605217 0.0125582189269133 no 3296 0.0156136609476955 1069 182045 SGTC_88 0180-0332 8.668 µM -2.16138298430023 0.0123173176280164 no 3297 0.0153328837021297 1065 3101745 SGTC_2060 5238662 140 µM -2.1676028299153 0.0121129822466089 no 3298 0.0150944591304402 1070 790130 SGTC_808 0711-0032 135 µM -2.1728021777363 0.0119444337578547 no 3299 0.0148976046713649 1079 4252555 SGTC_2478 5763493 32.33 µM -2.20353619383804 0.0109890889727876 no 3300 0.0137784894316319 1061 1365576 YLR208W SEC13 SGTC_2120 5538279 151.968 µM -2.21467503901592 0.010659639357001 no 3301 0.0133911886683381 1078 2058197 SGTC_1901 st060216 58.6 µM -2.22020761942696 0.0104992255816184 no 3302 0.0132023386692344 1056 688792 SGTC_1772 st048439 82.2 µM -2.22433473570801 0.0103809361463261 no 3303 0.0130629656578943 1065 2927068 YDL195W SEC31 SGTC_45 0kpi-0036 14.9 µM -2.22605662611462 0.0103319286448506 no 3304 0.0130051943594489 1067 2795021 SGTC_904 1141-0088 396 µM -2.2267830401801 0.0103113144209306 no 3305 0.0129808887027929 1083 1378119 SGTC_3356 9151811 4.48 µM -2.23168566583824 0.010173122881304 no 3306 0.0128178726415725 1079 1859254 YPR165W RHO1 SGTC_1645 Cervolide 78 µM -2.24424007869121 0.00982659019112794 no 3307 0.0124084793092356 1078 23173 A fragrance. SGTC_638 3970-0837 4.09 µM -2.25739910315229 0.00947447855911661 no 3308 0.0119915738575707 1074 4118451 YLR208W SEC13 SGTC_692 k241-0027 77.8 µM -2.26734479272668 0.00921571938089805 no 3309 0.0116845855831682 1072 3600480 SGTC_1892 st058411 7.36 µM -2.27032087267485 0.00913950213957045 no 3310 0.0115940607650946 1082 3934738 SGTC_1359 1582-0056 520 nM -2.27927493340154 0.00891350721571724 no 3311 0.0113253635680909 1088 3661189 SGTC_630 4356-0227 183 µM -2.29758283909843 0.0084666190441052 no 3312 0.0107927716472726 1081 779312 SGTC_801 0866-0028 10.1 µM -2.31573369894269 0.00804309805571324 no 3313 0.0102864066216141 1080 6849771 SGTC_2968 9090663 33.37 µM -2.32375901591177 0.0078618553649317 no 3314 0.0100692067303193 1052 25236811 SGTC_2994 9053520 71.4286 µM -2.32681873340628 0.00779370689974735 no 3315 0.00998745746039245 1077 4647384 SGTC_957 1187-1561 14.1 µM -2.34529351086996 0.00739316048755647 no 3316 0.00950605316399293 1074 1538454 SGTC_2770 toltrazuril 17.5 µM -2.34948372649785 0.00730487845785251 no 3317 0.00939973293407433 1059 68591 Kills coccidiodes. SGTC_2294 7971431 200 µM -2.36569259751518 0.00697206965919532 no 3318 0.00899819004149169 1083 5741572 SGTC_1788 fluconazole 20 µM -2.37928567932258 0.00670336386481819 no 3319 0.00867311339252899 1075 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1146 3579-1023 7 µM -2.38032075350096 0.00668328275922896 no 3320 0.00864878708513328 1086 X1146 SGTC_224 benfluorex 43.875 µM -2.3903756840355 0.00649096077199608 no 3321 0.0084155730694301 1084 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1316 1272-0050 65.9 µM -2.4107412215788 0.00611636548159624 no 3322 0.00796006986932196 1078 7340392 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.41177647981234 0.0060978455974007 no 3323 0.00793750524837557 1078 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2910 7948405 25.97 µM -2.41994456455044 0.00595345976234465 no 3324 0.00776143666203513 1071 2971328 SGTC_1752 st044819 83.042 µM -2.43149163070891 0.00575451721162044 no 3325 0.00751839785568256 1074 441209 YML126C ERG13 SGTC_1256 0570-0116 285 µM -2.43758451037342 0.00565194040625737 no 3326 0.00739287882579903 1080 410638 SGTC_1684 st024538 14.6195 µM -2.43865229883245 0.00563413178015164 no 3327 0.00737107259049347 1084 6732859 SGTC_1150 3909-7983 10.9 µM -2.47492425155999 0.00505803261650166 no 3328 0.00666322185620856 1086 23965914 SGTC_2813 7971799 71.43 µM -2.50957072588203 0.00455735014769223 no 3329 0.00604390033461829 1084 2234054 SGTC_1298 1079-1278 263 µM -2.51054772929675 0.00454389640842135 no 3330 0.0060272012624057 1081 2840950 SGTC_1132 3456-3614 2.5 µM -2.52400964073701 0.00436209728043583 no 3331 0.00580123733432887 1080 3125502 SGTC_1970 st070122 35.8 µM -2.5304392205089 0.0042775836836325 no 3332 0.00569599101039596 1080 102928 SGTC_2003 4023581 200 µM -2.54812708845575 0.004052588686973 no 3333 0.00541515040412875 1072 16641307 SGTC_123 0083-0120 66.675 µM -2.55669651992915 0.00394744098029478 no 3334 0.00528356817115155 1088 16001701 SGTC_691 1548-0686 185 µM -2.58650979823249 0.00360040517654423 no 3335 0.00484767069081048 1080 46495133 SGTC_2005 4024620 188 µM -2.59242535605065 0.00353489440392934 no 3336 0.00476509298846358 1084 236743 SGTC_2293 7624732 200 µM -2.60443360999136 0.00340519275369286 no 3337 0.00460131240007455 1086 894453 SGTC_1978 st071761 42 µM -2.61435038341886 0.003301322896631 no 3338 0.0044698652512142 1087 5147680 SGTC_3342 9147791 14.508 µM -2.62493629672736 0.00319359626306047 no 3339 0.00433325900279751 1082 1838168 SGTC_433 pimozide 108 µM -2.80943560664789 0.00175967975477458 no 3340 0.00248142230300117 1090 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2754 granisetron 64.02 µM -2.81045611437154 0.00175372348846885 no 3341 0.0024735667596085 1080 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1319 1306-0155 43.7 µM -2.85744732170931 0.001498541635359 no 3342 0.00213531757695665 1092 3122360 SGTC_295 k015-0027 31 µM -2.90348531315465 0.00128184505397092 no 3343 0.00184517139653845 1092 3887424 SGTC_1342 1486-1464 234 µM -2.9283322259724 0.00117718345825901 no 3344 0.00170392847430812 1089 3253938 SGTC_3148 9097893 49.47 µM -3.11411270571263 0.000610604771791215 yes 3345 0.000922494993953958 1082 17174100 SGTC_963 1269-2853 151 µM -3.31967537492327 0.000283642342891927 yes 3346 0.000450610892183152 1090 3668223 SGTC_1365 1672-3266 55.4 µM -3.38943278396597 0.000216552556521248 yes 3347 0.00035018688461677 1091 6415873 SGTC_2149 5554786 194.827 µM -3.71789971057706 5.68665338712952e-05 yes 3348 0.000100442992277085 1091 745063 YPR165W RHO1 SGTC_2990 9074105 71.4286 µM -3.94969217025536 2.07168880832326e-05 yes 3349 3.91258823413287e-05 1094 6502001 SGTC_2688 kanamycin b 96.69 µM -4.03554545338904 1.40551502920139e-05 yes 3350 2.72377958497901e-05 1083 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2481 5478948 45.16 µM -4.20807379915524 6.2995082293094e-06 yes 3351 1.28778379104582e-05 1095 77792 SGTC_518 1021-0119 62.6 µM -4.40606377112225 2.41516523757971e-06 yes 3352 5.26329921299981e-06 1094 1097762 SGTC_1993 st073995 70.8 µM -4.59362556404277 9.38230291081063e-07 yes 3353 2.17805353118056e-06 1095 3098394 SGTC_1367 1812-0510 76.9 µM -4.59614349094268 9.26167163729347e-07 yes 3354 2.15191184187069e-06 1093 1142582 YDR527W RBA50 SGTC_2694 st077685 81.9 µM -4.90125386800531 1.83889530723001e-07 yes 3355 4.76134517850899e-07 1095 2838096 SGTC_2690 usnic acid 100 µM -9.51591576462848 2.96401251912629e-23 yes 3356 9.00596848568931e-22 1095 5646 An anti-infective, antifungal and antitrichomonal agent.